bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problems experienced when swallowing solid oral dosage forms in older Japanese patients with dysphagia: A cross‐sectional study
Authors: Tanaka Kumi , Kikutani Takeshi , Tamura Fumiyo , Sato Shiho , Komagata Yuka , Shibasaki Ikumi , Tomioka Kosei , Ichikawa Yoko , Shiobara Yuichiro , Sato Takanobu , Tohara Takashi 
Published: April 2023

AbstractAimsWe aimed to assess the difficulty in taking solid oral dosage forms (SODFs) among older people with dysphagia and clarify the relationship between difficulty in swallowing SODFs and swallowing function.Methods and resultsOutpatients from a dysphagia clinic aged ≥65 years were asked yes‐or‐no questions about the applicability of eight items regarding difficulty in taking SODFs. Additionally, a videofluorographic swallowing study (VFSS) was performed to assess their swallowing function. The Kruskal–Wallis test and Spearman's rank correlation coefficient were used to analyze the relationship between difficulty in taking SODFs and swallowing function.ResultsAmong the 93 participants, the average number of SODFs consumed was 5.8 ± 3.1. In the questionnaire, the average number of “yes” answers was 2.2 ± 2.2, and 65 patients (71.0%) answered “yes” to at least one question. Additionally, no significant relationship was observed between the perceived difficulty in swallowing SODFs and VFSS findings.ConclusionApproximately 70% of participants reported subjective difficulty in taking SODFs, showing that patients uniformly reported perceived difficulty in taking SODFs regardless of actual swallowing function. The results of this study suggest that patients must be questioned thoroughly about their SODFs use, regardless of the objective severity of their dysphagia.
Bilateral palpebral reduction and concurrent mycoplasmosis in a wild Agassiz's desert tortoise (Gopherus agassizii)
Authors: Jacobson Elliott R. , Berry Kristin H. , Brooks Dennis E. , Roberts John F. 
Published: April 2023

AbstractA wild Agassiz's desert tortoise, Gopherus agassizii, with bilateral eyelid reduction and plaques of tissue covering the superior surface of both corneas was examined in the field and subsequently submitted to the University of Florida for diagnostics. Polymerase chain reaction (PCR), from a swab of both corneas, was positive for Mycoplasma agassizii. Two months later, the tortoise was euthanatized and necropsied. There was increased bulbar exposure associated with dermal excoriation of periocular scales in both superior and inferior palpebra resulting in an increased palpebral fissure opening. Concurrently, there was bilateral conjunctivitis of the nictitating membranes and squamous metaplasia of the bulbar conjunctiva. Using PCR, Mycoplasma testudineum, another pathogen of tortoises, was identified in both nasal cavities, and the upper respiratory tract histopathological findings were consistent with those described for M. testudineum in Agassiz's desert tortoises. Although eye disease has been reported in desert and gopher (Gopherus polyphemus) tortoises with mycoplasmosis, widespread loss of palpebral tissue, conjunctivitis of the nictitans, and squamous metaplasia of the bulbar conjunctiva have not been reported in tortoises.
Well‐being in acute care nurse managers: A risk analysis of physical and mental health factors
Authors: Martin Shirley D. , Urban Regina W. , Foglia Dorothy C. , Henson Jo Sheree , George Viji , McCaslin Tricia 
Published: April 2023

AbstractBackgroundNurse managers have experienced tremendous stress during the COVID‐19 pandemic, contributing to negative psychological outcomes. Positive professional well‐being is a construct that can be promoted to mitigate poor psychological outcomes and burnout in nurses. Little is known about the health, healthy behaviors, effects of stress on homelife, and well‐being of nurse managers in the United States (U.S.).AimsThe aims of the study were to explore nurse managers’ well‐being related to self‐reported stress and health perceptions and habits.MethodsA sample of 80 (41% response rate) nurse managers responded to a cross‐sectional web‐based survey sent via email in a southwestern U.S. 13‐hospital system. Nurses answered 39 quantitative questions about demographics, well‐being (9‐item Well‐Being Index [WBI]), perceptions of stress affecting homelife, and perceptions of health and health‐related behaviors.ResultsMean WBI (2.9 [2.7]) indicated risk for poor psychological outcomes. Managers (75%) reported stress from work affected their personal lives and a decline in overall health during the pandemic. Most (80%) reported burnout and emotional problems. Nurse managers had 8.1 times increased risk of poor WBI scores if stress from work affected their personal life than if they reported no spillover stress into their personal life (OR = 8.1, 95% CI [2.6, 25.0]).Linking Evidence to ActionFindings from this study add a nuanced understanding of nurse managers’ well‐being. The strongest risk factor for poor WBI scores was stress levels affecting personal life. Interventions to improve well‐being in nurse managers are needed. Limitations are the convenience sampling, limited geographic location, and response rate of <50%. Further research is needed to support nurse managers in stress reduction and development of boundaries that prohibit the spillover effect of workplace stress. Organizations may consider a combination of administrative support and changes as well as provision of on‐the‐job training of interventions that support individual well‐being.
Sensorimotor control in the congenital absence of functional muscle spindles
Authors: Macefield Vaughan G. , Smith Lyndon J. , Norcliffe‐Kaufmann Lucy , Palma Jose‐Alberto , Kaufmann Horacio 
Published: April 2023

AbstractHereditary sensory and autonomic neuropathy type III (HSAN III), also known as familial dysautonomia or Riley–Day syndrome, results from an autosomal recessive genetic mutation that causes a selective loss of specific sensory neurones, leading to greatly elevated pain and temperature thresholds, poor proprioception, marked ataxia and disturbances in blood pressure control. Stretch reflexes are absent throughout the body, which can be explained by the absence of functional muscle spindle afferents – assessed by intraneural microelectrodes inserted into peripheral nerves in the upper and lower limbs. This also explains the greatly compromised proprioception at the knee joint, as assessed by passive joint‐angle matching. Moreover, there is a tight correlation between loss of proprioceptive acuity at the knee and the severity of gait impairment. Surprisingly, proprioception is normal at the elbow, suggesting that participants are relying more on sensory cues from the overlying skin; microelectrode recordings have shown that myelinated tactile afferents in the upper and lower limbs appear to be normal. Nevertheless, the lack of muscle spindles does affect sensorimotor control in the upper limb: in addition to poor performance in the finger‐to‐nose test, manual performance in the Purdue pegboard task is much worse than in age‐matched healthy controls. Unlike those rare individuals with large‐fibre sensory neuropathy, in which both muscle spindle and cutaneous afferents are absent, those with HSAN III present as a means of assessing sensorimotor control following the selective loss of muscle spindle afferents.
Beyond an inflammatory mediator: Interleukin‐1 in neurophysiology
Authors: Lima Tatiane S. 
Published: April 2023

AbstractSince its discovery in the early 1940s, the interleukin‐1 (IL‐1) cytokine family has been associated primarily with acute and chronic inflammation. The family member IL‐1β is produced by different leucocytes, endothelial cells and epithelial cells. This cytokine has been characterized as a key modulator of inflammation and innate immunity because it induces the transcription of several downstream inflammatory genes. More recently, several groups have demonstrated that IL‐1β production is also required to maintain homeostasis in several organ systems. This review focuses on providing an overview of the more recently characterized role of IL‐1β in the physiology of the CNS. So far, IL‐1β signalling has been implicated in neuronal survival, neurite growth, synaptic pruning, synaptic transmission, neuroplasticity and neuroendocrine functions.
Cancer-Specific Survival after Limb Salvage versus Amputation in Children and Adolescents with Osteosarcoma: A Population-Based Analysis with Propensity Score Matching
Authors: Li Zhenwei , Xu Bo , Cai Jingjing , Zha Zhengang 
Published: April 2023

Background. The study aims to identify whether osteosarcoma patients of children and young adults will benefit from a survival profit from the choice of the operation method. Methods. The National Cancer Institute SEER database from 2000 to 2018 was selected for a retrospective analysis of 1630 children and young adults with a primary diagnosis of osteosarcoma, 1222 who underwent limb-preserving surgery, and 408 who underwent amputation. Confounders were controlled for by propensity score matching (PSM), cancer-specific survival (CSS) was analyzed using the Kaplan–Meier method, and univariate and multivariate Cox regression was used to analyze the factors influencing the prognosis of children and young osteosarcoma patients after surgery. A nomogram plot predicted 1-, 3-, and 5- survival rate in osteosarcoma. The model’s accuracy was validated by the area under the ROC and calibration curves. Results. After PSM, multifactor Cox regression analysis found AJCC Stage III-IV (CSS : HR = 5.26, 95% CI 1.95–14.18,

p
=
0.

001

; HR = 5.54, 95% CI 2.56–12.01,

p
<
0.

001

. Limb salvage surgery (CSS : HR = 0.58, 95% CI 0.44–0.77,

p
<
0.

001

) has independent impact factors for CSS prognosis. The survival curve before and after PSM showed that patients with osteosarcoma of children and young adults who underwent limb salvage surgery had a survival benefit compared with those who underwent amputation surgery. Gender, chemotherapy, histology, primary tumor site, stage, and surgical modality were modeled in a total of six variables in the nomogram. The model exhibited good predictive performance. The AUC were 0.823, 0.74, and 0.757 for training set at 1, 3, and 5 years, respectively. The AUC of validation set 0.666, 0.722, and 0.699 at 1, 3, and 5 years, respectively. The model also predicted CSS with good fidelity for both datasets. This model was significantly superior to the 8th edition of the AJCC TNM staging system, with a better net benefit in predicting CSS in children and young adults with osteosarcoma. Conclusion. Limb salvage surgery is an option for children and young adults with osteosarcoma and cancer-specific survival rates can be improved by receiving limb salvage surgery.
Therapeutic Landscape of AXL Receptor Kinase in Triple-Negative Breast Cancer
Authors: Ozyurt Rumeysa , Ozpolat Bulent 
Published: April 2023

Abstract
Early cancer recurrence, driven by resistance to therapeutics, is a major obstacle to overcome poor survival in triple-negative breast cancer (TNBC). Recently, overexpression of AXL has been identified as one of the key molecular determinants leading to the development of acquired resistance to chemotherapy and targeted anticancer treatments. AXL overactivation drives many hallmarks of cancer progression, including cell proliferation, survival, migration, metastasis, drug resistance, and is linked to poor patient survival and disease recurrence. Mechanistically, AXL represents a signaling hub that regulates a complex signaling pathways crosstalk. Therefore, emerging data highlight the clinical significance of AXL as an attractive therapeutic target. Currently, there is no FDA approved AXL inhibitor but several AXL small molecule inhibitors and antibodies are being tested in clinical settings. In this review we outline the functions and regulation of AXL, its role in resistance to therapy, and current strategies targeting AXL with emphasis on TNBC.
Exercise interventions for advanced cancer palliative care patients: A systematic literature review and descriptive evidence synthesis of randomized controlled trials
Authors: Rogers-Shepp India , Bhattacharya Souradeep , Mennillo Haran A , Kumar Ritika , Hsieh Ben , Anandarajah Gowri 
Published: April 2023

Background: Exercise is often recommended for cancer patients. However, for advanced cancer palliative care patients, it is unclear whether exercise, as a lifestyle intervention, is beneficial for palliative outcomes. Aim: To examine randomized controlled trials assessing the effectiveness of lifestyle exercise interventions on palliative outcomes in patients with advanced stage cancer. Design: Systematic review and descriptive evidence synthesis. Data sources: Pubmed/Medline, Embase, CINAHL, PsychInfo, and Web of Science were systematically searched from inception to 2022. Two reviewers identified articles and removed duplicates. Next two reviewers independently screened titles and abstracts and then assessed full-texts articles for eligibility. Finally, all six reviewers examined full-text articles for eligibility and conducted the evidence synthesis. Results: Eight randomized controlled trials were included. Studies were heterogeneous making direct comparisons challenging, but were grouped along three categories: aerobic, resistance, or resistance-aerobic exercises. One of three aerobic studies had positive quality-of-life outcomes. Fatigue improved in one aerobic and one combination resistance-aerobic study. Most resistance-aerobic studies and one aerobic study showed improved physical function. All resistance studies showed improvement in at least one outcome. Across all studies, ill health was the most common reason for participant dropout. The most commonly used assessment tools were: Functional Assessment of Cancer Therapy: Fatigue, European Organization for Research and Treatment of Cancer Quality-of-life Questionnaire Core 30, and accelerometer. Conclusion: Current randomized controlled trials regarding effects of exercise interventions on palliative outcomes for advanced cancer patients show great variability. While studies show promise, no generalizable conclusions can be made. Further research is needed.
Intractable Feeding Intolerance in Children With Severe Neurological Impairment: A Retrospective Case Review of Nine Children Known to a Pediatric Palliative Care Service
Authors: Katz Naomi T , Cooper Monica S , Kularatne Aeshan , Prebble Anna , McGrath Kathleen H , McCallum Zoe , Antolovich Giuliana , Sutherland Ingrid , Sacks Bronwyn H 
Published: April 2023

Background: Intractable feeding intolerance in children with severe neurological impairment (SNI) is poorly defined and understood. Objectives: (1) To describe 9 children with SNI, where intractable feeding intolerance was thought to be a contributor to their deterioration or death. (2) To consider terminology to describe the severe end of the spectrum of feeding difficulties in children with SNI. Results: Mean age at death was 10.3 years (range: 5 – 15.6), and median time from palliative care referral to death was 3.1 months. Location of death was home (n = 3), hospice (n = 1), and hospital (n = 5) with 1 death in intensive care. Gastrointestinal “failure” or “dysfunction” were documented for 7 children, (median time between documentation and death was 3.9 months (range: .1 to 13.1)). All children were fed via a gastrostomy tube during their life (median age of insertion 2.5 years (range: 1.2 to 6.8 years)), and 7 via the jejunal route (median age of insertion 9.2 years (range 2.4 to 14.7 years)). Children lived a median of 9 percent of their lives after jejunal tube feeding was commenced. No child had home-based parenteral nutrition. Multiple symptom management medications were required. Conclusion: ‘Intractable feeding intolerance’ describes a clinical crossroads in a child’s life where there is an opportunity to consider the appropriateness of further interventions. Further work should explore predictors of intractable feeding intolerance and the delicate balance between cause or contributor to death. The importance of clinician-family prognostic conversations and goal-concordant care both during life and in the terminal phase is highlighted.
The RANA Model Revisited: How a Primary Nursing Model for Professional Psychiatric Nursing Practice Has Withstood the Test of Time
Authors: Meyers Stacey M. , Roberts Patricia , Slade Maureen 
Published: April 2023

Objective: This article revisits the responsible, accountable nurse with authority (RANA) model and its continued application to psychiatric-mental health nursing care nearly 30 years after its development. It will ascertain key elements of the model that remain in use today, while identifying parts of the model that have transformed over the years. Methods: This article will also explore the theoretical underpinnings of the model, including Peplau’s interpersonal relations theory. The impact of the primary nursing and relationship-based care models that influenced the RANA role will also be explored. Results: Specific examples of how the RANA model has affected unit outcomes will be identified, such as improved patient safety measures and satisfaction with care. Conclusions: The nurse–patient relationship and therapeutic alliance is fundamental to the RANA model and directly affects patient outcomes.
Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg–Calvé–Perthes disease
Authors: Mishima Kenichi , Kamiya Yasunari , Matsushita Masaki , Imagama Shiro 
Published: April 2023

Purpose: To examine whether differences in bone resorption patterns in the anterior portion of the femoral head correlate with the prognosis of Legg–Calvé–Perthes disease. Methods: Seventy-eight patients with unilateral Legg–Calvé–Perthes disease, who were diagnosed after 6.0 years of age, underwent the Salter innominate osteotomy from 1987 to 2013, and were followed up to skeletal maturity. The anterior bone resorption pattern of the femoral head was evaluated from a frog-leg lateral hip radiograph made in the middle of the fragmentation period, and classified into two types, an epiphysis-preserved type (P) and a physis-disrupted type (D). The correlation between the type of bone resorption and the Stulberg outcome was analyzed. Results: The Stulberg outcomes were grade I for 9 patients, grade II for 31, grade III for 35, and grade IV for 3, with a mean follow-up period of 8.3 ± 2.7 years. Fifty-one patients demonstrated the type P hips and 27 did the type D hip. In a subset analysis of patients with the modified lateral pillar group-B hips in the younger group (6.0–8.9 years of age at diagnosis), the percentages of the favorable and unfavorable outcomes significantly differed between the two types ( p = 0.013). Anteroposterior enlargement of the affected femoral head was significantly greater in the type D hips than the type P hips ( p = 0.014). Conclusion: Unfavorable hip morphology at skeletal maturity can be predicted in patients with the lateral pillar group-B hips by focusing on bone resorption patterns of the anterior portion of the femoral head. Level of evidence: Level III, prognostic study.
Validity of Research Based on Publicly Obtained Data in Sports Medicine: A Quantitative Assessment of Concussions in the National Football League
Authors: Inclan Paul M. , Kuhn Andrew W. , Chang Peter S. , Mack Christina , Solomon Gary S. , Sills Allen K. , Matava Matthew J. 
Published: April 2023

Context: Numerous researchers have leveraged publicly available internet sources to publish clinical research concerning incidence and recovery from injuries in National Football League (NFL) players. Objective: This study aims to (1) provide a comprehensive systematic review of all publicly obtained data studies (PODS) regarding concussions in NFL athletes and (2) quantify the percentage of injuries identified by these studies in comparison with published concussion data from the NFL injury database. Study Selection: A systematic review was conducted in accordance with PRISMA guidelines to identify all published studies utilizing publicly obtained data regarding concussions in NFL athletes. Study Design: Systematic review. Level of Evidence: Level 4. Data Extraction: Manuscript details, factors related to the athletes of interest (eg, study period, positions included), and results (eg, concussion rate, number of total concussions, return-to-play data) were extracted independently by 2 authors. Results were compared with incident concussions reported from 2015 to 2019 by each medical staff member to the NFL database linked to the League’s electronic health record (EHR). Results: A total of 20 concussion-focused manuscripts based on PODS were identified from 2014 to 2020. PODS captured between 20% and 90% of concussions (mean, 70%) reported by medical staff to the injury database. PODS reported that 55% of concussions occurred on offensive plays, 45% on defensive plays and <1% occurred during special teams plays, compared with 44%, 37%, and 18%, respectively, as indicated by published data from the NFL injury database. When analyzed by position groups, running backs and quarterbacks comprised the most over-represented positions concussed in PODS, while offensive linemen, defensive backs, and linebackers comprised the most under-represented positions. Conclusion: PODS captured approximately 70% of concussions reported by NFL medical staff to the NFL injury database. There is heterogeneity in the degree to which PODS were able to identify concussions, with a bias toward concussions among players at higher profile positions.
Ultra-thin 2D bimetallic MOF nanosheets for highly sensitive and stable detection of glucose in sweat for dancer
Authors: Mao Yufei , Chen Tangchun , Hu Yifan , Son KwanJung 
Published: April 2023

AbstractThe measurement of glucose concentration in sweat is expected to replace the existing blood glucose detection, which realize the effective way of non-invasive monitoring of human glucose concentration in dancing. High precision glucose detection can be achieved by adjusting the electrode material of the sensor. Thus, in this work, the bimetallic organic frameworks (bi-MOFs) materials containing Mn and Ni ions (NiMn-MOF) with ultrathin nanosheets have been exquisitely designed. The ultrathin nanosheet and heterogeneous metal ions in the structure optimize the electronic structure, which improves the electrical conductivity of MOFs. The success of the preparation strategy leads the good electrocatalytic performance of NiMn-MOF for glucose detection. Detailedly, NiMn-MOF shows high sensitivity of 1576 μA mM−1 cm−2 in the linear range from 0 to 0.205 mM and the wide linear region of 0.255–2.655 mM and 3.655–5.655 mM were also observed. In addition, the high repeatability, reproductivity, long-term stability and ultra-low limited of detection (LOD, 0.28 μM, S/N = 3) provide foundation for the practical sensor application of this NiMn-MOF nanosheets. Remarkably, as designed NiMn-MOF sensor can accurately measure glucose in sweat showing great potential in the field of wearable glucose monitoring during dancing.