bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaccine-preventable disease in IBD
Authors: Zhou Felix , Kilby Kyle , Jones Jennifer 
Published: July 2023

The increasing prevalence of vaccine-preventable diseases (VPDs) in patients with inflammatory bowel disease (IBD) has given rise to increased awareness of the need to educate clinicians and patients about the critical role of immunization in this patient population. In 2023, it was estimated that in the Canadian population, 320,000 individuals (0.83%) were affected by IBD. Patients with IBD are at risk of vaccine-preventable diseases as the result of several factors, including potentially reduced efficacy and safety of vaccinations in the context of systemic immunosuppressive therapies administered for the management of IBD2 and a state of malnutrition caused by the disease.
Barriers to the administration of vaccinations include: Clinicians’ reluctance to immunize patients with IBD; patient lack of awareness regarding the critical importance of a structured vaccination protocol; gastroenterologists’ assumption that immunization falls under the auspices of the primary care provider (PCP); and limited time and resources.
The objective of this paper is to highlight the need for broader implementation of the 2021 Canadian Association of Gastroenterology (CAG) Guidelines concerning both live and inactivated vaccines in patients with IBD. This overview focuses on commonly encountered VPDs for which administration of live and non-live vaccines may be required and for which an IBD-specific deviation from the NACI recommendations have been made. The vaccines selected for this brief overview are also commonly administered in clinical practice. Clinicians may experience uncertainty in relation to management of these vaccinations in practice.
Modern Management of Chronic Kidney Disease in T2MD: A Practical Overview for Primary Care Providers
Authors: Girard Louis 
Published: July 2023

The development of chronic kidney disease (CKD) in patients with T2DM (CKD in T2DM) is a common and major comorbidity. Not only is it associated with progressive kidney disease and end-stage kidney disease (ESKD), it is also associated with very high risk for major adverse cardiovascular events (MACE) and heart failure (HF) events. CKD in T2DM is extremely costly from a health economic perspective; however, most importantly, it results in significant reductions in patient quality of life and survival. For several decades, there has been a lack of new therapeutic options to address residual cardiorenal risk. The traditional pillars of therapy include glycemic control with a HbA1C target of 6.5%, blood pressure control with a blood pressure target of less than 130 mmHg, and the use of renin angiotensin aldosterone inhibitors (RAASi). Recently, several options have emerged that can address residual kidney and cardiovascular risk in these patients, thereby providing organ protection. Importantly, these therapies are grounded in the foundation of solid randomized, controlled clinical trials and are now prevalent in the guidelines that inform the management of CKD in T2DM. The novel pillars for kidney and cardiovascular protection include sodium glucose luminal transported 2 inhibitors (SGLT2i) and finerenone, a non-steroidal mineralocorticoid receptor antagonist (nsMRA). This article highlights practical considerations of these pillars for primary care providers with a focus on kidney protection.
Update on the management of hypertension in 2023
Authors: Rabi Doreen M. 
Published: July 2023

Hypertension is the most common condition managed in the primary care setting. It is a potent but modifiable risk factor for cardiovascular disease (CVD) and premature mortality. Currently, approximately 25% of Canadian adults have a diagnosis of hypertension. However, the global community is experiencing challenges with optimizing hypertension management; it is estimated that at least 23% of individuals globally have effectively managed hypertension. Furthermore, if clinicians were able to identify and adequately intervene in these cases, we could prevent 10.8 million deaths per year. This statistic is extremely relevant to Canadian practitioners as our most recent Canadian data suggest that 34% of adults with hypertension are not achieving target blood pressure (BP) due to undertreatment or lack of awareness.
The undertreatment of hypertension is complex. There are a number of structural and environmental drivers of CV risk, and there is increasing recognition that if we are going to be effective at CV risk reduction, we must acknowledge the significant role that social determinants play in the development of risk factors including hypertension, smoking, obesity and diabetes.
The clinical guidance concerning hypertension may inadvertently contribute to the challenges we are seeing globally with hypertension management. There are numerous guidelines available to inform clinicians about how to provide supportive care for individuals with hypertension, and discordance between guidelines and the granularity of guidelines make implementation challenging. While there is disparity between guidelines, as well as differences regarding hypertension nomenclature, there is unanimous agreement that accurate BP measurement, risk-based thresholds for intervention, simplified approaches to pharmacotherapy, and well-structured care are the foundations of effective hypertension management.
Immunization in midlife
Authors: Brown Vivien 
Published: July 2023

Midlife is often defined as age 50 and above and is a period of life when patients commonly access the healthcare system, having recognized the need for various preventions. The Women’s Health Initiative (WHI) identified cardiovascular disease (CVD), cancer and osteoporosis as the most common causes of morbidity, disability, and poor quality of life in post-menopausal women. Healthcare professionals routinely screen patients with risk factors for these diseases and offer prevention and treatment to improve their quality of life. However, recommendations for immunizations are often neglected leading to unnecessary morbidity and mortality in our aging population. In Canada, it is estimated that 20,000 hospitalizations related to influenza occur each year and that 4,000 to 8,000 Canadians die from influenza-related complications alone. Vaccines can prevent the debilitating and fatal effects of infectious disease, yet clinical evidence has revealed an adult immunization gap. Midlife screening and intervention should serve as an immunization checkpoint, providing an opportunity for healthcare professionals to optimize quality of care and health maintenance in older patients.
Principles of anxiety management for family physicians
Authors: McIntosh Diane 
Published: July 2023

Family practitioners (FPs) play an essential role in mental healthcare delivery, providing triage, diagnosis, patient referral, and treatment. They are usually are patient’s first—and often their only—contact with mental healthcare services, due to the lack of access to psychiatric care. As such, FPs are commonly tasked with collecting and evaluating a broad range of symptoms that can be categorized as anxiety. The symptoms of anxiety have become increasingly ubiquitous, particularly due to the impact of the COVID-19 pandemic, leading many front-line providers to understandably feel anxious concerning optimal methods to assess and support these patients.
This article provides clinical pearls, supported by current empirical research, for assessing, diagnosing and treating patients presenting with anxiety.
Acute and prophylactic treatment of migraine
Authors: Marzoughi Sina , Spacey Sian 
Published: July 2023

Migraine is a chronic neurological disorder that causes significant disability in patients and has a substantial economic impact in Canada. Effective treatment for migraine will improve our patients’ quality of life; additionally, it will reduce the economic burden generated by healthcare visits and employee absenteeism.
The novel treatments in migraine target calcitonin gene-related peptide (CGRP), a neuropeptide which plays a role in the initiation of a migraine attack. Although our current understanding of migraine pathophysiology is incomplete, it is believed to involve the trigeminal nerve and its connections with the cerebral vasculature with nociceptive signals activated through a variety of neuropeptides including CGRP, substance P and nitric oxide.
As a result of an improved understanding of migraine pathophysiology, the past several years have seen the advent of a variety of new therapeutic options in both the acute and prophylactic management of migraine. Although these agents represent additional options in the clinician’s arsenal, they have, in addition, introduced challenges in determining their cost-effectiveness. In this review, we provide an update on new acute and prophylactic migraine therapies and how they integrate into current practice from a primary care perspective.
Pelatihan Kewirausahaan Pada Jamaah Ibu-ibu Masjid Nurul Huda Pondok Suruh Bimomartani Ngemplak Sleman
Authors: Hartadi Agung , Nurhadi Nugroho  
Published: July 2023

Di masa pandemi saat ini perekonomian masyarakat bawah lebih khusus rumah tangga mendapat dampak yang cukup signifikan. Daya jual maupun daya beli menurun, karena rumah tangga pendapatan berkurang atau justru tidak ada pendapatan sama sekali. Maka hal ini butuh perhatian dari berbagai pihak. Salah satu kegiatan yang membantu membangkitan perekonomian keluarga yakni dengan berwirausaha. Ibu-ibu yang merupakan anggota dari kelompok Jamaah Masjid Nurul Huda diharapkan mampu mendorong kegiatan ini. Dengan melalui kegiatan pelatihan kewirausahaan ini, para jamaah ibu-ibu dapat menghidupkan kembali kegiatan wirausaha yang pasif karena dampak pandemi. Meski kegiatan wirausaha ini masih sebatas jual beli produk lebih tepatnya resseller, namun diharapkan setelah mendapat penyuluhan ini dapat menjadikan anggotanya memproduksi produk sendiri dan dijual sesama jamaah maupun dengan warga sekitar. Sehingga kegiatan wirausaha dapat menyelamatkan perekonomian keluarga.
Preoperative Oral Administration of Yunnan Baiyao and Its Effect on Coagulation Parameters in Tick-Borne Disease and/or Heartworm Seropositive Dogs: A Pilot Study
Authors: Rodriguez Adria , Shiau Deng-Shan , Levinson Keri , Peck Elizabeth 
Published: July 2023

The overall goal of this clinically focused pilot study was to investigate the preoperative benefit of oral administration of Yunnan Baiyao (YB) to Ehrlichia. canis, Anaplasma platys and/or heartworm seropositive canines. A total of 12 clinically normal dogs undergoing sterilization procedures were randomly subdivided into Control/Placebo Group (n=6) or Treatment Group (n=6). Each patient received three oral doses of YB (0.5g/5kg) or placebo every twelve hours with the last dose given the evening before surgery. Citrated blood measurements for prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen were obtained before the first YB dose and after the third dose. Intraoperative blood loss was estimated by blood-soaked gauze sponge counts. The study found the Control Group’s mean aPTT increased by 3.8% while the Treatment Group’s decreased by 0.42%. PT values were slightly decreased in both groups. Fibrinogen decreased in controls (9.7%) but had a modest increase in treated dogs (12.4%). Intraoperative blood loss was increased in controls (3%) compared to the Treatment Group (mean±SD: 6.6±6.8 vs. 6.4±3.6, respectively). Findings from the study which suggest preoperative benefits from YB administration to seropositive dogs include stabilizing aPTT and fibrinogen values along with reduced intraoperative blood loss in YB treated dogs. Although these modest findings were not statistically significant in this small study, the biological trends suggest potential benefits of preoperative administration of YB before routine elective surgeries in seropositive patients and support a clinical trial with larger sample size.
Effect of Professional Commitment, Ethical Environment and Personal Cost on Intention to do Whistleblowing
Authors: Khairunnisa Khairunnisa 
Published: July 2023

This research was conducted to find out what factors influence a person's intention to do whistleblowing. The purpose of this study is to find out whether professional commitment, ethical environment, and personal costs affect the intention to do whistleblowing at the Public Works and Public Housing Office of Jambi Province. This study uses primary data and was obtained through questionnaires distributed to Civil Servants who work at the Public Works and Public Housing Office of Jambi Province with a research sample of 71 respondents who work at the agency with the sampling technique using simple random sampling. The data analysis method used in this research is multiple linear regression analysis using the SPSS 25 program. The results of this study indicate that professional commitment, ethical environment, and personal costs have an influence on the intention to do whistleblowing. So it can be concluded that the higher the individual's professional commitment, the higher the intention to do whistleblowing, the higher the understanding of ethics in a work environment, the higher the intention to do whistleblowing, and the higher the personal cost, the higher the intention to do whistleblowing.
La fenomenología social de Alfred Schütz: un aporte desde miradas complejas y transmetódicas de investigación.
Authors: Contreras Colmenares Adrián Filiberto 
Published: July 2023

La investigación, en ciertos niveles académicos, debe trascender lo convencional y el sencillo acto de revelar los hallazgos. La narrativa científica debe estar matizada de complejidad; además, ha de estar guiada por un sintagma problematizador, un sintagma teleológico y un sintagma ontológicoepistemológico; ellos imbrican una arquitectura transmetódica y compleja para el descubrimiento del saber. En esa perspectiva, lo teorético aquí tiene como punto focal la complejidad, una mirada que permite valorar la fenomenología social para entender el mundo cotidiano y la socialidad. Teleológicamente, la disertación se orienta a resemantizar y resignificar la fenomenología social de Alfred Schütz, desde una mirada compleja, transmetódica y la hermenéutica diatópica, pues la propia fenomenología social se erige como transmetódica y transfilosófica. En lo metodal, esta narrativa tiene como criterios fundantes la reflexividad y la hermenéutica diatópica, para saciar la inquietud que emerge de la resignificación de la fenomenología social de Alfred Schütz. Como corolario, se hace necesario considerar la complejidad y la transmetódica en la que se erige la misma fenomenología social; está apoyada en la hermenéutica diatópica y ecosófica para entender al otro, desde su propia acción. Todo ello, se consustancia con la complejidad del entramado social.
SISTEM PAKAR PENENTUAN TREATMENT MASALAH KULIT WAJAH PADA PASIEN NAAVAGREEN CIANJUR MENGGUNAKAN ALGORITMA DEMPSTER SHAFER
Authors: Widaningsih Resita Agustin 
Published: July 2023

Kulit adalah organ yang sangat penting bagi manusia yang berfungsi untuk melindungi dari berbagai macam bahaya luar, kulit juga sebagai indra peraba, mengatur suhu tubuh, serta sebagai pelindung dari organ dalam. Khususnya kulit wajah yang sering mendapat perhatian karena memiliki permukaan lapisan kulit yang tipis, maka dari itu kulit wajah perlu perawatan secara khusus. Treatment atau perawatan wajah merupakan perlakuan, pengobatan, hingga pelayanan, bertujuan untuk mendapatkan kulit wajah yang sehat, dan terawat. Naavagreen cianjur merupakan klinik kecantikan yang menyediakan jasa konsultasi mengenai masalah kulit wajah, layanan treatment, serta menyediakan skincare. Semakin tingginya minat masyarakat untuk melakukan treatment tidak diimbangi dengan sistem yang baik. Terbatasnya jumlah dokter kulit membuat pasien tidak dilayani secara maksimal. Dengan adanya sistem pakar penentuan treatment masalah kulit wajah pada pasien naavagreen cianjur menggunakan algoritma dempster shafer diharapkandapat membantu pasien naavagreen untuk dapat konsultasi secara online kapanpun dan dimanapun.
Pelatihan Pengembangan Pembelajaran Literasi Numerasi Sejak Dini Pada Guru di KB TK Tunas Sumber Jaya
Authors: Nafisah Durrotun , Rachma Evi Aulia , Kuswanto  , Nurdiana Ratna , Youhanita Ety , Astutik Nur Fithria Wiji , Eryadini Ninies 
Published: July 2023

Program Pengabdian Masyarakat bertujuan untuk memenuhi Tri Dharma perguruan Tinggi. Keunggulan program ini salah satunya membantu paguyuban dalam mengatasi masalah yang sedang terjadi. Permasalahan yang terjadi yaitu lemahnya pembelajaran literasi numerasi khususnya di Kelompok Belajar Taman Kanak-Kanak. Kegiatan pengabdian masyarakat ini bertujuan untuk mengembangkan pembelajaran literasi numerasi pada guru di KB TK Tunas Sumber Jaya untuk meningkatkan kemampuan literasi numerasi pada anak-anak usia dini karena pendidikan Taman Kanak-Kanak merupakan pondasi dasar yang sangatlah penting bagi proses perkembangan anak, sehingga sudah selayaknya anak mendapatkan fasilitas dalam pemenuhan kebutuhan di setiap perkembangannya. Rancangan prosedur kegiatan program PKM yang diusulkan dalam usulan ini meliputi tahapan: (1) persiapan; (2) pelaksanaan; dan (3) observasi serta evaluasi. Kesimpulan dari pengabdian menunjukkan pemahaman & keterampilan pembelajaran literasi numerasi guru KB TK Tunas Sumber Jaya mengalami peningkatan. Anak didik sangat senang, karena kegiatan literasi, numerasi dan life skill disampaikan guru dengan cara yang menyenangkan, mudah, menarik, dan menantang pemahaman anak.
„Die Menschenwürde ist unantastbar“ – auch im Gefängnis
Authors: KRETSCHMER Joachim 
Published: July 2023

„Alle Personen, denen die Freiheit entzogen ist, sind unter Achtung ihrer Menschenrechte zu behandeln“.1 So lautet Nr. 1 der Grundprinzipien der Europäischen Strafvollzugsgrundsätze des Europarates von 2020.
Es ist eine rechtsstaatliche Selbstverständlichkeit in einem liberalen Verfassungs- und Rechtsstaat, dass die Menschenwürde und die Menschenrechte auch in den Justizvollzugsanstalten = Gefängnissen eines Staates gelten und von den staatlichen Stellen geachtet werden. Auch Strafgefangene und sonstige Personen in anderen Formen des Freiheitsentzugs sind Bürger und Bürgerinnen. Es bedurfte aber 1972 eines Urteils des Bundesverfassungsgerichts (=BVerfG) in Karlsruhe, damit sich diese rechtsstaatliche Selbstverständlichkeit in Gesetzgebung und in der Rechtspraxis durchsetzt.
Cadmium Priming Alleviates Salinity Induced Oxidative Stress in Pigeon Pea
Authors: Sahu Abhaya Kumar , Behera Beda Saurav , Kumari Punam 
Published: July 2023

Plants are regularly exposed to an adverse environment due to their sessile nature which has negative impacts on plant development and productivity. In this study, the effect of seeds priming with 50 µM CdCl2 in ameliorating the salinity (200 mM NaCl) induced oxidative stress in pigeon pea was assessed. Hydrogen peroxide (H2O2) and malondialdehyde (MDA) content was reduced in Cd+SS (50 µM CdCl2 primed followed by 200 mM NaCl treatment) tissues as compared to salt stressed (SS) tissues. The activities of superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), and guaicol peroxidase (GPX) were increased in Cd+SS tissues as compared to SS tissues. Moreover, the concentrations of ascorbic acid (ASC) and proline were also increased in Cd+SS tissues as compared to SS tissues. Thus, a low dose Cd priming provided tolerance to pigeon pea seedlings by activating the antioxidant machinery.
Distribution of Body Mass Index and Abdominal Obesity in Bayelsa State with Associated Interleukin-2 Gene Expression
Authors: Ogbole Faith Ajiebabhio , Sanugba Evans Egereghe 
Published: July 2023

Aims: The aim of the present study was to evaluate the distribution, prevalence and determinants of obesity, overweight and abdominal obesity in Bayelsa State, Nigeria as well as associated IL-2 gene expression.
Study Design: A community based cross sectional study design was employed to randomly select 420 participants (aged 18 – 65 years) for the study.
Methodology: The study participants were grouped into normal, overweight and general obesity based on their body mass index (BMI) and sub-grouped into normal and abdominal obesity based on their waist circumference. Weighing scale, metre rule and measuring tape were used to measure weight, height and waist circumference respectively. Real time PCR was used to quantify IL-2 gene expression.
Results: The BMI distribution of adults in Bayelsa State was symmetrical around the mean (27.25 ± 4.12). Mean waist circumference was 95.27 ± 15.92 (men 97.51 ± 12.38; women 93.41 ± 18.15 cm). The prevalence of obesity, overweight and abdominal obesity were 26.2% (male, 10.7%; females, 15.5%), 35.2% (males, 16.4%; female, 18.8%), and 62.9% (males, 28.1% females, 34.8%) respectively. Compared with the normal group, a significant upregulation of IL-2 gene expression was found in the overweight, general obesity and abdominal obesity groups (p < 0.05). Significant association of the following determinants with obesity was found: both sexes, age group 36 - 55 years, working as small and medium scale business entrepreneurs and civil servants. Age group 56 – 65 years and female sex were associated with abdominal obesity.
Conclusion: The present study found a high prevalence of overweight, general obesity and abdominal obesity in Bayelsa State and associated over expression of IL-2 gene. Findings may have implication for IL-2 based biomarker and drug development. Interventions to reduce BMI and waist circumference in Bayelsa State is emphasized in the present study.
Influence of Parkia biglobosa (Jacq.) R. Br. Ex G. Don on the Herbaceous Vegetation in the Katouré Valley of the Commune of Nyassia (Basse Casamance-Senegal)
Authors: Bassene Jean , Diedhiou Siré , Goudiaby Arfang O. K. , Sambou Antoine , Sow Mamadou , Sagna Yves P. , Diatta Yaya , Fall Saliou , Ndoye Ibrahima , Diallo Mariama D. 
Published: July 2023

Aims: Trees outside of protected areas play an important role in providing ecosystem services. They participate in the development of the mat by creating favorable conditions for the development of grasses. The influence of trees on the development and distribution of grasses is not well known. It is in this sense that this study was conducted to determine the effect of Parkia biglobosa cover on the composition, diversity, structure and spatial distribution of herbaceous vegetation.
Place and Duration of Study: The study was carried out in the commune of Nyassia in Lower Casamance on a site identified as a Parkia biglobosa park in the Katouré valley in August 2021.
Methodology: Floristic surveys were conducted under (R, R/2, R and 2R) and outside the control tree canopy.
Results: It was found that the number of species under the tree canopy ranged from 13 to 16 species and was greater than that observed outside the canopy (6 species). Species such as Bracharia deflexa, Cyperus esculentus, Echinochloa colona, Indigofera heudelotii and Pentodon pentandrus were the most frequently encountered in the surveys under the tree canopy (0R, R/2 and R). In contrast, Andropogon gayanus and Bulbostylis capillaris were the most abundant species in the noncanopy surveys. The canopy cover of P. biglobosa, which ranged from 70±17.6 (2R) to 83±19.4 (R/2), was higher than in the uncovered level (54±15.4). Diversity analysis revealed that the canopy surveys 0R (0.80±0.06), R/2 (0.81±0.04) and R (0.77±0.06) were the most diverse.
Conclusion: The presence of Parkia biglobosa influenced the presence of herbaceous species and improved habitat conditions.