bluuebunny/crossref_metadata_2025_split huggingface dataset:
HuMSC-EV induce monocyte/macrophage mobilization to orchestrate neovascularization in wound healing process following radiation injury
Authors: Loinard Céline , Ribault Alexandre , Lhomme Bruno , Benderitter Marc , Flamant Stéphane , Paul Sandrine , Dubois Valérie , Lai Ruenn Chai , Lim Sai Kiang , Tamarat Radia 
Published: February 2023

AbstractThis study aims to investigate the mechanisms of human mesenchymal stem cell-derived extracellular vesicles (HuMSC-EV)-induced proangiogenic paracrine effects after radiation injury. HuMSC-EV were locally administered in mice hindlimb following 80-Gy X-ray irradiation and animals were monitored at different time points. HuMSC-EV improved neovascularization of the irradiated tissue, by stimulating angiogenesis, normalizing cutaneous blood perfusion, and increasing capillary density and production of proangiogenic factors. HuMSC-EV also stimulated vasculogenesis by promoting the recruitment and differentiation of bone marrow progenitors. Moreover, HuMSC-EV improved arteriogenesis by increasing the mobilization of monocytes from the spleen and the bone marrow and their recruitment into the muscle, with a pro-inflammatory potential. Importantly, monocyte depletion by clodronate treatment abolished the proangiogenic effect of HuMSC-EV. The critical role of Ly6C(hi) monocyte subset in HuMSC-EV-induced neovascularization process was further confirmed using Ccr2−/− mice. This study demonstrates that HuMSC-derived EV enhances the neovascularization process in the irradiated tissue by increasing the production of proangiogenic factors, promoting the recruitment of vascular progenitor cells, and the mobilization of innate cells to the injured site. These results support the concept that HuMSC-EV might represent a suitable alternative to stem cells for therapeutic neovascularization in tissue repair.
Perspectives on fundamental cosmology from Low Earth Orbit and the Moon
Authors: Bertone Gianfranco , Buchmueller Oliver L. , Cole Philippa S. 
Published: February 2023

AbstractThe next generation of space-based experiments will go hunting for answers to cosmology’s key open questions which revolve around inflation, dark matter and dark energy. Low earth orbit and lunar missions within the European Space Agency’s Human and Robotic Exploration programme can push our knowledge forward in all of these three fields. A radio interferometer on the Moon, a cold atom interferometer in low earth orbit and a gravitational wave interferometer on the Moon are highlighted as the most fruitful missions to plan and execute in the mid-term.
Biomolecular analyses enable new insights into ancient Egyptian embalming
Authors: Rageot Maxime , Hussein Ramadan B. , Beck Susanne , Altmann-Wendling Victoria , Ibrahim Mohammed I. M. , Bahgat Mahmoud M. , Yousef Ahmed M. , Mittelstaedt Katja , Filippi Jean-Jacques , Buckley Stephen , Spiteri Cynthianne , Stockhammer Philipp W. 
Published: February 2023

AbstractThe ability of the ancient Egyptians to preserve the human body through embalming has not only fascinated people since antiquity, but also has always raised the question of how this outstanding chemical and ritual process was practically achieved. Here we integrate archaeological, philological and organic residue analyses, shedding new light on the practice and economy of embalming in ancient Egypt. We analysed the organic contents of 31 ceramic vessels recovered from a 26th Dynasty embalming workshop at Saqqara1,2. These vessels were labelled according to their content and/or use, enabling us to correlate organic substances with their Egyptian names and specific embalming practices. We identified specific mixtures of fragrant or antiseptic oils, tars and resins that were used to embalm the head and treat the wrappings using gas chromatography–mass spectrometry analyses. Our study of the Saqqara workshop extends interpretations from a micro-level analysis highlighting the socio-economic status of a tomb owner3–7to macro-level interpretations of the society. The identification of non-local organic substances enables the reconstruction of trade networks that provided ancient Egyptian embalmers with the substances required for mummification. This extensive demand for foreign products promoted trade both within the Mediterranean8–10(for example,Pistaciaand conifer by-products) and with tropical forest regions (for example, dammar and elemi). Additionally, we show that at Saqqara,antiuandsefet—well known from ancient texts and usually translated as ‘myrrh’ or ‘incense’11–13and ‘a sacred oil’13,14—refer to a coniferous oils-or-tars-based mixture and an unguent with plant additives, respectively.
Identification of key genes related to immune infiltration in cirrhosis via bioinformatics analysis
Authors: Du Tong-Yue , Gao Ya-Xian , Zheng Yi-Shan 
Published: February 2023

AbstractCirrhosis is the most common subclass of liver disease worldwide and correlated to immune infiltration. However, the immune-related molecular mechanism underlying cirrhosis remains obscure. Two gene expression profiles GSE89377 and GSE139602 were investigated to identify differentially expressed genes (DEGs) related to cirrhosis. Enrichment analysis for DEGs was conducted. Next, the immune infiltration of DEGs was evaluated using CIBERSORT algorithm. The hub DEGs with tight connectivity were identified using the String and Cytoscape databases, and the expression difference of these hub genes between normal liver and cirrhosis samples was determined. Moreover, in order to evaluate the discriminatory ability of hub genes and obtained the area under the receiver operating characteristic curve values in the GSE89377 and GSE139602 datasets. Finally, the association between hub DEGs and immune cell infiltration was explored by Spearman method. Among the 299 DEGs attained, 136 were up-regulated and 163 were down-regulated. Then the enrichment function analysis of DEGs and CIBERSORT algorithm showed significant enrichment in immune and inflammatory responses. And four hub DEGs (ACTB, TAGLN, VIM, SOX9) were identified, which also showed a diagnostic value in the GSE89377 and GSE 139,602 datasets. Finally, the immune infiltration analysis indicated that, these hub DEGs were highly related to immune cells. This study revealed key DEGs involved in inflammatory immune responses of cirrhosis, which could be used as biomarkers for diagnosis or therapeutic targets of cirrhosis.
Modelling evolution of a large, glacier-fed lake in the Western Indian Himalaya
Authors: Gantayat Prateek , Ramsankaran RAAJ 
Published: February 2023

AbstractIn this study, we simulated the evolution of a large glacier-fed lake called the Gepan Gath lake located in Western Himalayas by numerically modelling the evolution of the Gepan Gath glacier that feeds the lake. Due to the extremely large volume and steep lake sidewalls, the lake has been classified as ‘critical’ or prone to hazards such as lake outburst floods in the future, by various scientific investigations. This modelling was carried out by a 1D model that is based on the principle of mass conservation. The 1D model was forced with the glacier surface mass balance (SMB). Due to non-availability of published in-situ estimates, the SMB was estimated using an energy balance-based model on station derived and reanalysis derived meteorological data. Modelled glacier length fluctuations for over 134 years matched reasonably well with that of observed within the RMSE error ~ 320 m. In addition to that, between 2004 and 2019, the modelled and observed lake lengths were in agreement with each other with the RMSE ~ 110 m. Modelled glacier lake lengths also match well with published, satellite imagery derived lengths within 15% uncertainty. The uncertainty in future lake length fluctuations is within 100–200 m. Our ultimate aim is to show that numerical ice-flow modelling can be an asset in modelling glacier-fed lake evolution even in the case of highly data-sparse regions of the IHR.
Prevalence of early and late menopause and its determinants in Rafsanjan cohort study
Authors: Vatankhah Hajar , Khalili Parvin , Vatanparast Mahboubeh , Ayoobi Fatemeh , Esmaeili-Nadimi Ali , Jamali Zahra 
Published: February 2023

AbstractOur investigation aimed to evaluate the prevalence of early and late menopause and its determinants in adult women of Rafsanjan cohort study. We used data obtained from the Rafsanjan Cohort Study, as a part of the prospective epidemiological research studies in Iran. In this cross-sectional research, 2002 postmenopausal women were included in the present study. Menopause age were divided into three groups (≤ 41 years, 42–54 years, and ≥ 55 years) based on the 10th and 90th percentile. The association between age at menopause with demographic and reproductive characteristics and some clinical risk factors of women was evaluated by logistic regressions. The mean age at menopause among the study participants was 48.63 ± 5.37 years. In this study, 11.49% and 11.39% of the women experienced early and late menopause respectively. After adjusting for all potential confounders, the results showed that taller and smoker women had higher odds of early menopause (OR 1.03, 95% CI 1.00–1.06) and OR 1.85, 95% CI 1.01–3.41) respectively) and women with history of using hormonal contraceptive more than median had lower odds of early menopause (OR 0.61, 95% CI 0.41–0.91). Also older women (OR 8.65, 95% CI 5.31–14.08) and women with a history of diabetes (OR 2.42, 95% CI 1.63–3.60), hypertension (OR 2.06, 95% CI 1.42–2.97), thyroid disease (OR 1.85, 95% CI 1.07–3.20) and depression (OR 2.00, 95% CI 1.35–2.97) had higher odds of late menopause. The results showed that the year of birth, height, smoking, history of diabetes, hypertension, thyroid disease and depression and using hormonal contraceptive were significantly associated with the menopausal age. Since age at menopause can affect subsequent health in women, understanding the determinants of menopausal age is important and should be pursued.
Effect of duodenal-jejunal bypass on diabetes in the early postoperative period
Authors: Okikawa Shohei , Kashihara Hideya , Shimada Mitsuo , Yoshikawa Kozo , Tokunaga Takuya , Nishi Masaaki , Takasu Chie , Wada Yuma , Yoshimoto Toshiaki 
Published: February 2023

AbstractMetabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
Tamarixia radiata global distribution to current and future climate using the climate change experiment (CLIMEX) model
Authors: Souza Philipe G. C. , Aidoo Owusu F. , Farnezi Priscila K. B. , Heve William K. , Júnior Paulo A. S. , Picanço Marcelo C. , Ninsin Kodwo D. , Ablormeti Fred K. , Shah Mohd Asif , Siddiqui Shahida Anusha , Silva Ricardo S. 
Published: February 2023

AbstractThe phloem-limited bacteria, “Candidatus Liberibacter asiaticus” and “Ca. L. americanus”, are the causal pathogens responsible for Huanglongbing (HLB). The Asian citrus psyllid Diaphorina citri Kuwayama (Hemiptera: Liviidae) is the principal vector of these “Ca. Liberibacter” species. Though Tamarixia radiata Waterston (Hymenoptera: Eulophidae) has been useful in biological control programmes against D. citri, information on its global distribution remains vague. Using the Climate Change Experiment (CLIMEX) model, the potential global distribution of T. radiata under the 2050s, 2070s, and 2090s for Special Report on Emissions Scenarios A1B and A2 was defined globally. The results showed that habitat suitability for T. radiata covered Africa, Asia, Europe, Oceania, and the Americas. The model predicted climate suitable areas for T. radiata beyond its presently known native and non-native areas. The new locations predicted to have habitat suitability for T. radiata included parts of Europe and Oceania. Under the different climate change scenarios, the model predicted contraction of high habitat suitability (EI > 30) for T. radiata from the 2050s to the 2090s. Nevertheless, the distribution maps created using the CLIMEX model may be helpful in the search for and release of T. radiata in new regions.
The Chemistry of Plants: Perfumes, Pigments and Poisons
Authors: Séquin Margareta 
Published: February 2023

Why are some plants so important to humans? The chemistry of the plants has a lot to do with it!
The plant world offers a fascinating way to explore basic chemistry concepts. The spectacular variety of colors, fragrances and other characteristics of plants are driven by the seemingly subtle differences in the structure and properties of organic compounds. Well-known flowers, like daffodils and narcissus, are examples of plants that provide ample perfumes, pigments and poisons as part of their intricate and fascinating chemistry.
This second edition retains it accessibility, expanding on the first edition and combining scientific concepts with colorful pictures and stories in simple, clear language. Readers will find introductory information on some chemistry and plant biology. This prepares them for the more complex chemical structures that compose plant substances, many of them of vital importance to humans. The final chapter has been expanded, in particular the sections on medicinal plants and on genetic modification. The end-of chapter references have been thoroughly updated with articles, books, and relevant websites that illustrate the topics discussed.
Dr Margareta Sequin, an organic chemist and plant enthusiast, has taught popular undergraduate college level courses on plant chemistry to non-chemistry majors and has led numerous field seminars for the general public. The comments and questions from these audiences and the topics that especially captured people’s interest have greatly shaped this book.
The Chemistry of Plants addresses an audience with little previous chemistry knowledge, but will appeal to the expert reader looking for an understanding of more complex plant compounds. It can be used both as a text to introduce organic chemistry as it relates to plants and as a text of reference for more advanced readers.
More Molecules of Murder
Authors: Emsley John , Emsley John , Emsley John , Hargreaves Anthony E 
Published: February 2023

How can a plant as beautiful as the foxglove be so deadly and yet for more than a century be used to treat heart disease? The same is true of other naturally occurring molecules as will be revealed in this current book by award-winning author and chemist, John Emsley.
More Molecules of Murder follows on from his highly-acclaimed earlier book Molecules of Murder, and again it deals with 14 potential poisons; seven of which are man-made and seven of which are natural. It investigates the crimes committed with them, not from the point of view of the murderers, their victims, or the detectives, but from the poison used. In so doing it throws new light on how these crimes were carried out and ultimately how the perpetrators were uncovered and brought to justice.
Each chapter starts by looking at the target molecule itself, its discovery, its chemistry, its often-surprising use in medicine, its effects on the human body, and its toxicology. The rest of the chapter is devoted to murders and attempted murders in which it has been used. But, be reassured that murder by poison is not the threat it once was, thanks to laws which restrict access to such materials and to the skills of analytical chemists in detecting their presence in incredibly tiny amounts.
Poisons and Poisonings: Death by Stealth
Authors: Hargreaves Tony , Emsley John , Hargreaves Anthony E 
Published: February 2023

It is London in the 1890s. A young woman has just taken a dose of a tonic she’s been given in the belief that it will improve her complexion. About ten minutes pass and she starts to experience breathing difficulties. Another minute and she collapses. Mercifully, death arrives but the poison has not yet finished, for the process of rigor mortis has set in with unusual speed. Her body is frozen into a rigid and contorted mass. This is the horror of strychnine, the nastiest of poisons. Despite knowing all the dreadfulness of this poison, Dr Thomas Neill Cream, the Lambeth Poisoner, used it to kill several prostitutes. And who knows how many other victims experienced the horror of strychnine, for it was by no means an uncommon poison.
Today, there may well be more poisons available to the individual than ever before, but there are also advances in medical examination and forensic analysis that increase the likelihood of the poisoner being caught. This book will examine poisons, both natural and man-made menaces, and cases based on a particular poison as well as information about how forensic analysis is conducted. Appealing to scientists and non-scientists alike, this enthralling book will entertain and educate and bring the reader up to date with how important chemical analysis is in crime detection.
The Science of Sugar Confectionery
Authors: Edwards William P 
Published: February 2023

Since the first edition of The Science of Sugar Confectionery (2000), the confectionery industry has responded to ever-changing consumer habits. This new edition has been thoroughly revised to reflect industry’s response to market driven nutrition and dietary concerns, as well as changes in legislation, labelling, and technology.
Building on the strengths of the first edition, the author’s personal knowledge and experience of the sugar confectionery industry is used to provide a thorough and accessible account of the field. Written so the reader needs no more than a rudimentary level of chemistry, this book covers the basic definitions, commonly used and new ingredients in the industry. It then discusses the various types of sugar confectionery including "sugar glasses" (boiled sweets), "grained sugar products" (fondants), toffees and fudges, "hydrocolloids" (gums, pastilles and jellies) and concludes with a new chapter on future outlooks.
Featuring expanded coverage of special dietary needs, covering topics such as vegetarianism and veganism, religious requirements and supplemented products, this new edition reflects current and evolving needs in the sugar confectionery field.
Essential Mathematics for NMR and MRI Spectroscopists
Authors: Brown Keith C 
Published: February 2023

Beginning with a review of the important areas of mathematics, this book then covers many of the underlying theoretical and practical aspects of NMR and MRI spectroscopy from a maths point of view. Competence in algebra and introductory calculus is needed but all other maths concepts are covered. It will bridge a gap between high level and introductory titles used in NMR or MRI spectroscopy. Uniquely, it takes a very careful and pedagogical approach to the mathematics behind NMR and MRI. It leaves out very few steps, which distinguishes it from other books in the field.
The author is an NMR laboratory manager and is sympathetic to the frustrations of trying to understand where some of the fundamental equations come from hence his desire to either explicitly derive all equations for the reader or direct them to derivations. This is an essential text aimed at graduate students who are beginning their careers in NMR or MRI spectroscopy and laboratory managers if they need an understanding of the theoretical foundations of the technique.
Food: The Chemistry of its Components
Authors: Coultate Tom 
Published: February 2023

First published in 1984, and now in its 6th edition, this book has become the classic text on food chemistry around the world. The bulk components – carbohydrates, proteins, fats, minerals and water, and the trace components – colours, flavours, vitamins and preservatives, as well as food-borne toxins, allergens, pesticide residues and other undesirables all receive detailed consideration. Besides being extensively rewritten and updated a new chapter on enzymes has been included. At every stage attention is drawn to the links between the chemical components of food and their health and nutritional significance.
Features include:"Special Topics" section at the end of each chapter for specialist readers and advanced students; an exhaustive index and the structural formulae of over 500 food components; comprehensive listings of recent, relevant review articles and recommended books for further reading; frequent references to wider issues eg the evolutionary significance of lactose intolerance, fava bean consumption in relation to malaria and the legislative status of food additives around the world.
Food: The Chemistry of its Components will be of particular interest to students and teachers of food science, nutrition and applied chemistry in universities, colleges and schools. Its accessible style ensures that it will be invaluable to anyone with an interest in food issues.
Consistency of the average flux of solar energetic particles over timescales of years to megayears
Authors: Usoskin I. G. , Koldobskiy S. A. , Poluianov S. V. , Raukunen O. , Vainio R. , Kovaltsov G. A. 
Published: February 2023

Aims. Solar energetic particles (SEPs) have been measured directly in space over the past decades. Rare extreme SEP events are studied based on terrestrial cosmogenic proxy data for the past ten millennia. Lunar rocks record the average SEP fluxes on the megayear timescale. The question of whether the SEP fluxes averaged over different timescales are mutually consistent is still open. Here we analyze these different datasets for mutual consistency.
Methods. Using the data from directly measured SEPs over the past decades and reconstructions of extreme SEP events in the past, we built a distribution function of the occurrence of annual SEP fluences for SEPs with energies above 30, 60, 100, and 200 MeV. The distribution function was fit with the Weibull and other types of distributions, and the long-term average SEP flux was computed and compared with the megayear SEP flux estimated from lunar data.
Results. In contrast to the current paradigm, the direct space-era data are not representative of the long-term averaged SEP flux because they are only 20–55% of it, while the major fraction was formed by rare extreme SEP events in the past. The combined statistics of direct and proxy data are fully consistent with megayear lunar data, implying that our knowledge of the whole range of the SEP fluxes, from frequent weak to rare extreme events, is now consistent.