bluuebunny/crossref_metadata_2025_split huggingface dataset:
­Pharmacokinetics of antimalarial drugs used to treat uncomplicated malaria in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Authors: Nakijoba Ritah , Nakayiwa Kawuma Aida , Ojara Francis Williams , Tabwenda Jovia C. , Kyeyune Jacqueline , Turyahabwe Christine , Asiimwe Simon Peter , Magoola Johnson , Banda Clifford George , Castelnuovo Barbara , Buzibye Allan , Waitt Catriona 
Published: August 2023

Background: Data surrounding the exposure of the breastfed infant to drugs and any associated risks are sparse. Drugs usually are transferred to milk in small quantities, and many have been used without obviously noticeable infant toxicity for many years – this lack of a ‘safety signal’ has further reduced the interest in studying mother-to-infant transfer of the drugs. In sub-Saharan Africa, pregnant women are at risk of Plasmodium falciparum infection, and one in four women have evidence of placental infection at the time of delivery. Artemisinin-based combination therapies (ACTs), primarily artemether-lumefantrine (AL), are the current first-line treatment for uncomplicated Plasmodium falciparum malaria, with the same dosing recommendations in breastfeeding women as those in the adult population. Dihydroartemisinin-piperaquine (DP) is routinely used as an alternative to AL in Uganda. However, lactation pharmacokinetics (PK) of ACTs are unknown. Pharmacokinetic characterization of anti-malarial transfer to breast milk and breastfed infants is crucial in understanding the potential consequences to the infant, in terms of therapeutic- and prophylactic effects as well as potential toxicity. Methods: This observational study will enroll 30 mother-infant pairs, and aims to characterize the breastmilk transfer of antimalarial medications (AL and DP) to infants when these ACTs are administered to mothers as part of treatment for uncomplicated malaria. In addition, we will assess the mental health of the breastfeeding mothers enrolled as well as the well-being of their children. PK samples of maternal blood, breastmilk and breastfeeding infant’s blood will be obtained at specific times points. Pharmacokinetic data will be analyzed using a population pharmacokinetic approach. Conclusions: We anticipate that findings from this research will guide to develop a PK model describing lumefantrine and piperaquine disposition and will provide a framework to foster other lactation pharmacokinetic studies in different disease areas.
Feasibility of an improved knotless method of chest drain wound closure:a prospective cohort clinical trial
Authors: Zhao Lei , Wang Longfei , Wang Jin , Zhao Shilei , Wang Jinna , Gu Chundong 
Published: August 2023

Objective: Chest tube management plays a key role in minimising erioperative period. We have improved the knotless method to chest tube wounds. In this article, we demonstrate the clinical bility and safety of this method. Method: From 13 October 2018–3 January 2019, patients were ecutively included in our study at the First Affiliated Hospital of n Medical University, Dalian, China. They were separated into approximately equally sized groups—the knotless group and the entional group. Our improved knotless method was performed ose the chest tube wounds of patients in the knotless group, and onventional method using the pre-existing U-shaped string to the chest tube wounds of patients in the conventional group. Patient clinical information, tube-related complications, retreatment s and cosmetic scores were compared between the groups. Results: The cohort comprised 102 patients; 47 in the knotless group and 55 in the conventional group. There were no statistically significant differences in patient clinical information or tube-related complications between the two groups (p>0.05; both comparisons). In the knotless group, retreatment times were shorter (p<0.001) and cosmetic scores were higher (p<0.001). Conclusion: This study showed that our new knotless method is safe and has wide clinical feasibility. The new method also improved patient cosmetic scores. Furthermore, it decreased the patients’ economic burdens.
Comparison of the results of stop-start technique with stop-start technique and sphincter control training applied in premature ejaculation treatment
Authors: Doğan Kazım , Keçe Cem 
Published: August 2023

Background
The aim of this study is to compare the results of stop-start technique with stop-start technique together with sphincter control training applied in the treatment of premature ejaculation.

Methods
This research was conducted as a pre-test post-test quasi-experimental study. The sample of the study consisted of 80 men. The study was conducted on men who applied to the urology outpatient clinic of LIV Hospital, a prıvate hospital, in Gaziantep, Turkey, between 01 October 2021 and 01 March 2022. “Personal Information Form”, “Intravaginal Ejaculation Latency Time (IELT)”, “Fold Increase Intravaginal Ejaculation Latency Time (F-IELT)” “Premature Ejaculation Diagnostic Tool (PEDT) Questionnaire” and “Arabic Index Premature Ejaculation (AIPE)” were used as the data collection tools. Behavioral therapy, consisting of a total of 6 sessions, was applied once every two weeks, with each session lasting for 45 minutes. After 3rd and 6th months from the beginning of the application, the data collection tools were applied again. “Stop-Start Technique (Group A)” and “Stop-Start Technique and Sphincter Control Training (Group B)” were used in the treatment.

Results
In both groups, the IELT and AIPE values after 3rd and 6th months from the beginning of the application were statistically higher than those obtained before (p<0.05). IELT and AIPE values increased more in Group B than Group A (p<0.05). F-IELT values after 6th months from the beginning of the application were found to be statistically significant with a low level of effect size than those obtained before (p<0.05, Cohen’s d = 0.027). In both groups, the PEDT values in the 3rd and 6th months after the application were statistically lower than those seen before (p<0.05). PEDT value decreased more in Group B than Group A (p<0.05). The differences between the two groups’ IELT (Cohen’s d = 0.011), AIPE (Cohen’s d = 0.044), and PEDT (Cohen’s d = 0.066) values in the 3rd month after the application and IELT (Cohen’s d = 0.025), AIPE (Cohen’s d = 0.048), and PEDT (Cohen’s d = 0.024) values in the 6th month after the application were found to be clinically weak.

Conclusions
It was determined that the stop-start technique given to men with premature ejaculation increased the time spent in the vagina and eliminated the problem of premature ejaculation. It was determined that the stop-start technique in combination with sphincter control training were more effective than the stop-start technique alone.
miR34a-5p impedes CLOCK expression in chronodisruptive C57BL/6J mice and potentiates pro-atherogenic manifestations
Authors: Vyas Hitarthi , Vohra Aliasgar , Upadhyay Kapil , Thounaojam Menaka , Jadeja Ravirajsinh , Dalvi Nilay , Bartoli Manuela , Devkar Ranjitsinh 
Published: August 2023

Introduction
Altered circadian rhythms underlie manifestation of several cardiovascular disorders, however a little is known about the mediating biomolecules. Multiple transcriptional-translational feedback loops control circadian-clockwork wherein; micro RNAs (miRNAs) are known to manifest post transcriptional regulation. This study assesses miR34a-5p as a mediating biomolecule.

Method
8–10-week-old male C57BL/6J mice (n = 6/group) were subjected to photoperiodic manipulation induced chronodisruption and thoracic aortae were examined for miRNA, gene (qPCR) and protein (Immunoblot) expression studies. Histomorphological changes were assessed for pro-atherogenic manifestations (fibrillar arrangement, collagen/elastin ratio, intima-media thickening). Computational studies for miRNA-mRNA target prediction were done using TargetScan and miRDB. Correlative in vitro studies were done in serum synchronized HUVEC cells. Time point based studies were done at five time points (ZT 0, 6, 12, 18, 24) in 24h.

Results
Chronodisruption induced hypomethylation in the promoter region of miR34a-5p, in the thoracic aortae, culminating in elevated miRNA titers. In a software-based detection of circadian-clock-associated targets of miR34a-5p, Clock and Sirt1 genes were identified. Moreover, miR34a-5p exhibited antagonist circadian oscillations to that of its target genes CLOCK and SIRT1 in endothelial cells. Luciferase reporter gene assay further showed that miR34a-5p interacts with the 3’UTR of the Clock gene to lower its expression, disturbing the operation of positive arm of circadian clock system. Elevated miR34a-5p and impeded SIRT1 expression in a chronodisruptive aortae exhibited pro-atherogenic changes observed in form of gene expression, increased collagen/elastin ratio, fibrillar derangement and intimal-media thickening.

Conclusion
The study reports for the first time chronodisruption mediated miR34a-5p elevation, its circadian expression and interaction with the 3’UTR of Clock gene to impede its expression. Moreover, elevated miR34a-5p and lowered SIRT1 expression in the chronodisruptive aortae lead off cause-consequence relationship of chronodisruption mediated proatherogenic changes.
Influence of psychological capital on core competency for new nurses
Authors: Wang Junqiang , Chen Jiya , Zheng Lingzhi , Zeng Baojin , Yan Xiaoting , Xia Mengjie , Chen Lili 
Published: August 2023

Background
The development of core competency is crucial for the success of new nurses, enabling them to deliver high-quality care. Psychological capital (PsyCap), encompassing self-efficacy, optimism, hope, and resilience, significantly influences individuals’ abilities and achievements across various professions. However, limited research has specifically examined the impact of PsyCap on the core competency of new nurses. This study aims to bridge this gap by investigating the relationship between PsyCap and core competency development in new nurses, providing valuable strategic insights for improving PsyCap and promoting core competence acquisition.

Methods
142 new nurses were chosen for the investigation using a convenient cluster sampling method. The questionnaire included components on socio-demographic characteristics, the Competency Inventory for Registered Nurses (CIRN), and the PsyCap Questionnaire-24 (PCQ-24). The t-test, One-Way ANOVA, Pearson correlation analysis and hierarchical multiple regression were used for statistical analysis.

Result
The number of valid questionnaires was 138, and the effective return rate was 97.2%. The overall mean score for core competencies was 171.01 (SD 25.34), and the PsyCap score was 104.76(SD 13.71). The PsyCap of new nurses was highly correlated with core competency, with a correlation coefficient of r = 0.7, p < 0.01. Self-efficacy of PsyCap is a significant independent predictor of core competency (adjust R2 = 0.49).

Conclusion
Self-efficacy in PsyCap is an important predictor of new nurses’ core competency. Nursing managers should pay sufficient attention to the cultivation and development of new nurses’ PsyCap, with particular emphasis on enhancing self-efficacy to improve their core competency.
Feasibility, acceptability and potential helpfulness of the PROACTIVE intervention in Flanders, Belgium: A survey study
Authors: Wang Shanshan , de Almeida Mello Johanna , S. Mittelman Mary , Declercq Anja 
Published: August 2023

Background/objectives
This study aimed to explore the feasibility of a Flemish adaptation of the New York University Caregiver Intervention (i.e., PROACTIVE intervention) modifying the recruitment and intervention content for informal caregivers of people with early cognitive decline, and across different subgroups. A feasibility study is necessary in order to reduce research waste for intervention adaptation and evaluation.

Methods
Researchers constructed, tested, and sent out a survey consisting of 43 questions on the following topics: awareness of symptoms of early cognitive decline, levels of cognitive performance using the updated Cognitive Performance Scale (CPS2), acceptability, and potential helpfulness of the intervention, and sociodemographic characteristics. Quantitative data were analyzed using descriptive statistics and logistic regression with SAS 9.4©. Qualitative data were analyzed using an inductive content analysis.

Results
A total of 463 informal caregivers completed the survey (mean age 58.8 ± 11.8, 83.6% female). Among them, 230 respondents who cared for people with cognitive decline indicated they would probably or certainly participate in the study. Identified factors influencing the recruitment were cognition, co-habitation, education, and employment status. Over half of the target caregivers indicated almost all services from the intervention could satisfy their needs. A majority perceived the PROACTIVE intervention would be helpful (69.4%), especially the CPS2 = 3 (76.1%) and CPS2 = 4 (74.1%) subgroups.

Conclusion
The recruitment of target participants for a subsequent RCT evaluation study is feasible, and identified associated factors should be considered during the recruitment process. The PROACTIVE intervention and core components except ‘peer-group participation’ were perceived as helpful by most caregivers. The CPS2 = 3–4 subgroups were most accepting of the intervention and were most likely to benefit from the intervention.
Crafting Luxury: Craftsmanship, Manufacture, Technology and the Retail Environment, Mark Bloomfield, Shaun Borstrock, Silvio Carta and Veronica Manlow (2022)
Authors: Arrington Deidra W. 
Published: August 2023

Review of: Crafting Luxury: Craftsmanship, Manufacture, Technology and the Retail Environment, Mark Bloomfield, Shaun Borstrock, Silvio Carta and Veronica Manlow (2022)
Bristol: Intellect Ltd., 187 pp.,
ISBN 978-1-78938-580-9, p/bk, $45.00
Fashioning the Afropolis: Histories, Materialities and Aesthetic Practices, Kerstin Pinther, Kristin Kastner and Basile Ndjio (eds) (2022)
Authors: Divita Lorynn 
Published: August 2023

Review of: Fashioning the Afropolis: Histories, Materialities and Aesthetic Practices, Kerstin Pinther, Kristin Kastner and Basile Ndjio (eds) (2022)
London: Bloomsbury Publishing, 240 pp.,
ISBN 978-1-35017-952-3, h/bk, $103.50
Risk factors associated with Surgical Site Infection in a Haitian teaching hospital: a case-control study
Authors: Joseph Thaïmye , Valsaint Christopher W. , Jonacé Gérald 
Published: August 2023

Background.- This study’s objective is to analyzethe different risk factors associated with the occurrence of surgical site infections(SSI)in patients operated for acute abdomen atHôpital de l’Universitéd’Etatd’Haiti from January 2018 to December 2020.
Methods.- This is a unmatched case-control study. Were included: patients who had undergone surgery for acute abdomen and had developed a SSI. By measuring the association between each risk factor and the occurrence ofSSI, their implication in the occurrence ofSSIhas been determined.
Results.- Of the thirteen risk factors identified, in the 87 files selected, a high incidence (25.29%) ofSSIswas associated with the following risk factors: anemia, duration of interventions, NNIS index and reintervention.
Conclusion. - Anemia, duration of interventions, NNIS index and reintervention were the main risk factors strongly associated with the occurrenceofSSI.
Incompressible limit for compressible viscoelastic flows with large velocity
Authors: Hu Xianpeng , Ou Yaobin , Wang Dehua , Yang Lu 
Published: August 2023

Abstract
We are concerned with the incompressible limit of global-in-time strong solutions with arbitrary large initial velocity for the three-dimensional compressible viscoelastic equations. The incompressibility is achieved by the large value of the volume viscosity, which is different from the low Mach number limit. To obtain the uniform estimates, we establish the estimates for the potential part and the divergence-free part of the velocity. As the volume viscosity goes to infinity, the dispersion associated with the pressure waves tends to disappear, but the large volume viscosity provides a strong dissipation on the potential part of the velocity forcing the flow to be almost incompressible.
Nachhaltiges Forschungsdatenmanagement gemeinsam umsetzen
Authors: Augsten Marie Theres , Fischer Patryk , Helbig Kerstin , Jacob Boris , Jäckel Denise , Kienbaum Janna , Lehmann Anna , Odebrecht Carolin , Paßmann Sven , Schreiber Stefanie , Söring Sibylle , Steinke Britta 
Published: August 2023

Zusammenfassung
Nach zwei Jahren Projektlaufzeit lud der DFG-geförderte Projektverbund FDNext zu einem zweiten Community-Workshop ein. Unter dem Motto „Nachhaltiges Forschungsdatenmanagement gemeinsam umsetzen“ wurde eine projektweite Ergebnisbilanz gezogen und im Rahmen einer Online-Veranstaltung vorgestellt. Einzelne Formate ermöglichten den Austausch und die Diskussion zur Vision des Kulturwandels und eines ganzheitlichen FDMs durch Initiativen wie die Nationale Forschungsdateninfrastruktur (NFDI) sowie die Möglichkeiten der Zusammenarbeit zwischen einzelnen Konsortien und Hochschulen. Dabei wurden Aufgaben identifiziert, welche nur gemeinsam mit der FDM- bzw. Wissenschafts-Community bearbeitet werden können.
Raum für Veränderung: Wie die Lernwerkstatt das Lernen im Austausch fördert
Authors: Krähling-Pilarek Maren 
Published: August 2023

Zusammenfassung
Seit zwölf Jahren ist die Badische Landesbibliothek in der Vermittlung von Informationskompetenz aktiv. Mit der Eröffnung der Lernwerkstatt im Frühjahr 2023 hat sie nicht nur einen neuen Lernort innerhalb der Bibliothek geschaffen, sondern auch ihr Programmangebot stark vergrößert. Die Lernwerkstatt ist ein Lernort, der mit seiner technischen und räumlichen Ausstattung sowie mit seinem Veranstaltungsprogramm das „Lernen im Austausch“ fördert. In diesem Artikel werden Konzeptionierung und Umsetzung dieses Lernortes vorgestellt.
Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway
Authors: Wang Xueling , Yan Xiaoting , Huang Fang , Wu Lijuan 
Published: August 2023

Abstract
The aim of this study was to investigate the effects of adiponectin (APN) on the proliferation and phenotypic transformation of human skin fibroblasts (HSFs) induced by TGF-β1. Primary fibroblast cultures were collected from prepuce surgery, and the cell viability and proliferative activity of HSFs were detected by Cell Counting Kit-8 and EdU assays. In addition, cell migration was detected by Transwell assay. The protein levels of related genes in HSF were detected by Western blotting. The results showed that the proliferation and migration abilities of HSF in the TGF-β1 group were significantly improved, and the relative protein expression levels of PCNA, α-SMA, and Collagen I in the TGF-β1 group were greatly increased. Furthermore, TGF-β1 stimulated the phosphorylation of p38 in HSF, while APN pretreatment significantly inhibited the TGF-β1-induced phosphorylation of p38. Additionally, blocking the p38 MAPK signaling pathway relieved the injury in the HSF induced by TGF-β1 and enhanced the therapeutic effect of APN in the TGF-β1-treated HSF. In conclusion, APN inhibits TGF-β1-induced HSF proliferation and myofibroblast phenotypic transformation by activating the p38 MAPK signaling pathway. APN is expected to become a potential target for preventing and treating skin fibrosis and pathological scars.
The G protein-coupled receptor-related gene signatures for predicting prognosis and immunotherapy response in bladder urothelial carcinoma
Authors: Wan Zhengqiang , Wang Yinglei , Li Cheng , Zheng Dongbing 
Published: August 2023

Abstract
Bladder urothelial carcinoma (BLCA) is the most common malignant tumor of the urinary tract with a high lethality rate, and its immunotherapy resistance and tumor recurrence have become a major challenge in its clinical treatment. G Protein-Coupled Receptors (GPRs) are the largest family of receptors on the cell membrane surface, involved in multiple signaling pathways, and are excellent targets for oncology drug action. The transcriptome profile, single cell transcriptome profile, and clinical data of BLCA were extracted and integrated from TCGA and GEO databases, respectively. The GPR-related genes were obtained from GSEA-MSigDB database. The GPR-related gene signatures of 15 genes were constructed by using the methods of least absolute shrinkage and selection operator regression, multifactor Cox model. At the same time, tumor microenvironment (TME)-score signatures were constructed based on the immune microenvironment of BLCA, and GPR-TME-score signature was further constructed. The stability of this model was verified by using the external dataset GSE160693. We constructed risk groups by combining BLCA patient prognostic information, and with the help of BLCA scRNA transcriptome profiling, we explored differences in prognosis, immune scores, cell–cell interactions, tumor mutational burden, immune checkpoints, and response to immunotherapy in each risk group. We found that the GPR-TME-score signature was an independent prognostic factor for BLCA patients. the TME-score was a protective factor for the prognosis of BLCA patients. Among BLCA patients, GPR-high + TME-low risk group had the worst prognosis, while GPR-high + TME-high risk group had the best prognosis, and the latter had better immune score and immunotherapy response. The above differences in immune response among the subgroups may be related to the higher immune cell infiltration in the GPR-high + TME-high group. GPR-related gene signatures and TME are closely related to BLCA prognosis and immunotherapy, and GPR-related gene signature can be a useful tool to assess BLCA prognosis and immunotherapy response.
An exploration of the physical, optical, mechanical, and radiation shielding properties of PbO–MgO–ZnO–B2O3 glasses
Authors: Aloraini Dalal A. , Kumar Ashok , Almuqrin Aljawhara H. , Abualsayed Mohammad Ibrahim 
Published: August 2023

Abstract
This study presents the results of an investigation into the physical, optical, and mechanical characteristics of glasses prepared from a mixture of ZnO, MgO, B2O3, and PbO. It was found that increasing the concentration of PbO in the glasses led to an increase in both the density (ρ) and molar mass (M). The addition of PbO also affected the packing arrangement of oxygen atoms in the glass network, resulting in changes to the oxygen molar volume (V
o) and oxygen packing density. Furthermore, the investigation found that the optical basicity (Ʌ
th) of the glass elevated with increasing PbO concentration. Finally, the behavior of the average electronegativity (χav) and electronic polarizability (

α

o

−
2

{\alpha }_{{\rm{o}}}^{-2}

) with respect to the concentration of PbO in the glasses is discussed, whereby the addition of PbO affected the glasses’ mechanical characteristics as follows: (i) the addition of PbO increased the complexity of the glass network by enhancing the average cross-link density (

n

c

̅

\bar{{n}_{{\rm{c}}}}

) and the number of bonds per unit volume of the glasses (n
b); (ii) the glasses’ Young’s modulus (E), bulk modulus (B), and shear modulus (G) declined as the mol percent of the PbO increased; (iii) the longitudinal modulus (L) reduced but remained greater than G; (iv) the glass network cross-linking reduced the Poisson ratio (σ); (v) the glasses’ fractal bond connectivity (d) values indicated a three-dimensional network; and (vi) lead oxide hardened the glass, suggesting that a stronger structure manifests. These findings collectively demonstrate that PbO improves the rigidity and interconnectivity of glass. The gamma radiation-shielding characteristics of the glasses were evaluated using the Phy-X software in the 0.015–15 MeV energy range. The radiation-shielding properties of the studied glasses can be compared with other materials by introducing a new parameter known as the radiation coefficient ratio (R). It is observed that Q4 glass sample had superior shielding performance.