bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks
Authors: van de Kooij Bert , van der Wal Fenna J. , Rother Magdalena B. , Creixell Pau , Stout Merula , Wiegant Wouter , Joughin Brian A. , Vornberger Julia , van Vugt Marcel A.T.M. , Altmeyer Matthias , Yaffe Michael B. , van Attikum Haico 
Published: September 2023

AbstractHomologous Recombination (HR) is a high-fidelity repair mechanism of DNA Double-Strand Breaks (DSBs), which are induced by irradiation, genotoxic chemicals or physiological DNA damaging processes. DSBs are also generated as intermediates during the repair of interstrand crosslinks (ICLs). In this context, the Fanconi anemia (FA) core complex, which is effectively recruited to ICLs, promotes HR-mediated DSB-repair. However, whether the FA core complex also promotes HR at ICL-independent DSBs remains controversial. Here, we identified the FA core complex members FANCL and Ube2T as HR-promoting factors in a CRISPR/Cas9-based screen with cells carrying the DSB-repair reporter DSB-Spectrum. Using isogenic cell-line models, we validated the HR-function of FANCL and Ube2T, and demonstrated a similar function for their ubiquitination-substrate FANCD2. We further show that FANCL and Ube2T are directly recruited to DSBs and are required for the accumulation of FANCD2 at these break sites. Mechanistically, we demonstrate that FANCL ubiquitin ligase activity is required for the accumulation of the nuclease CtIP at DSBs, and consequently for optimal end-resection and Rad51 loading. CtIP overexpression rescues HR in FANCL-deficient cells, validating that FANCL primarily regulates HR by promoting CtIP recruitment. Together, these data demonstrate that the FA core complex and FANCD2 have a dual genome maintenance function by promoting repair of DSBs as well as the repair of ICLs.
Consumers’ response to CSR statement type in social crowding
Authors: Liu Xiaoping , Wang Shiyu , Liang Yingqian 
Published: September 2023

PurposeBased on the construal level theory, this research study examines the interactive effect between social crowding and corporate social responsibility (CSR) statement type on consumers' purchase intention.Design/methodology/approachThe authors conducted two empirical experiments on a total of 508 subjects.FindingsThere is an interactive effect between social crowding and CSR statement type on consumers' purchase intention. Specifically, in high social crowding situations, concrete CSR statements lead to consumers' higher purchase intention, while in low social crowding situations, abstract CSR statements lead to consumers' higher purchase intention. Self-construal and processing fluency play a moderating and mediating role in the mechanism.Originality/valueThis research study contributes to the theoretical understanding of the interaction between social crowding and CSR statements, enriching the field of consumer behavior research on social crowding. Additionally, it offers practical insights for enterprises on how to present CSR information in crowded situations.
“Regions” as brands: an empirical validation of consumer-based brand equity framework and demonstration of cross-over effect
Authors: Bandyopadhyay Argho , Hall John , Wong Ho Yin , Lockshin Larry , Zhang Yunen , Thaichon Park 
Published: September 2023

PurposeThis study aims to empirically validate the holistic consumer-based brand equity (CBBE) framework and establishment of the cross-over effect using consumer preferences for wine “regions.”Design/methodology/approachThe authors utilize a sample of 275 regular wine purchasers in Australia, who were aged above 30 years old and had consumed regional wine in the last 3 months through an online consumer panel survey.FindingsBy testing competing CBBE models, the main research model was found to have the greatest predictive ability, due to its inclusion of both the rational and emotional paths and the cross-over effect between consumer brand judgment and brand feeling. This paper indicates that consumers enhance brand equity and develop a strong ongoing relationship with regional wine brands by simultaneously engaging in both mental behavior paths, where, in the meantime, rational processing has a cross-over effect on emotional processing.Originality/valueThis study expands the brand management literature by answering the future research on the CBBE model identified by Hall et al. (2021). Moreover, it establishes the underexplored cross-over effect within the CBBE literature. Furthermore, it adds to the marketing and wine-marketing literature by extending the concept of the brand to other attributes in consumer choice, such as a wine region as outlined by Giacomarra et al. (2020). Thus, this study advances the existing branding knowledge in a practical sense, which enables regional wine marketers and wine retailers to undertake promotional and product development strategies accordingly.
Examining the impact of indoor environmental quality on individual productivity of knowledge workers in green certified buildings
Authors: Nurick Saul , Thatcher Andrew 
Published: September 2023

Purpose
This paper aims to investigate green buildings and individual productivity, specifically within the context of indoor environmental quality (IEQ) within green certified office buildings. The purpose of the research was to determine how self-assessed productivity levels were influenced by the indoor environment of the office building.

Design/methodology/approach
Qualitative data analysis was conducted via semi-structured interviews in two financial services companies (FSCs), both based in green certified office buildings in South Africa. Thematic analysis was conducted to extract common themes from the data. Furthermore, the data were compared to previous research to identify new potential pathways or provide support for existing pathways.

Findings
The main findings were that physical components, such as temperature, lighting, ventilation and noise, contribute depending on the respondent to individual productivity, engagement, organisational commitment and psychological wellbeing. Safety, underpinned by location and amenities, was a new component not previously considered that subtly contributed to individual productivity.

Originality/value
The research provides valuable insight into the contributing factors that impact individual productivity within a green certified office building, as previous researchers have yet to reach a consensus on the relationship between individual productivity and IEQ in green certified office buildings.
Effect of industry 4 emerging technology on environmental sustainability of textile companies in Saudi Arabia: mediating role of green supply chain management
Authors: Bhatti Muhammad Awais , Aljoghaiman Abdulaziz , Kaliani Sundram Veera Pandiyan , Ghouri Arsalan 
Published: September 2023

PurposeThe research objective was to check the impact of industry 4 (I4) technologies on environmental sustainability (ENS) with the mediating role of green supply chain management (GSCM) of textile companies in Saudi Arabia.Design/methodology/approachData was collected from those respondents who were linked with management and also have knowledge of I4 technologies. The researchers distributed 500 questionnaires among respondents for data collection, 350 questionnaires were received, and used for analysis. The researchers employed the quantitative research approach and cross-sectional research design.FindingsThe results indicate that I4 has a positive effect on ENS and GSCM practices except for green purchasing where I4 has an insignificant impact on green purchasing. On the other hand, GSCM practices also significantly mediate between I4 and ENS except for green purchasing which has an insignificant mediating effect.Practical implicationsThis study has a great theoretical contribution to literature as it provides strategic insight to managers as well as policymakers. From the perspective of resource-based view, this study is supportive to use I4 technology practices in GSCM. Furthermore, the current research suggests managers to implement I4 technologies and adopt the GSCM practices. These practices should be part of environmental strategies. The implementation of these practices will assist in building a strong reputation and satisfaction of customers and to fulfill the requisites of stakeholders.Originality/valueThe research was conducted with the extended framework of the mediating effect of GSCM between I4 and ENS of Saudi Arabia textile companies which are considered to be a pioneer study in the extant literature.
The mediating role of capital investment and financial sector in the energy-pollution discourse
Authors: Mesagan Ekundayo Peter , Vo Xuan Vinh 
Published: September 2023

PurposeThe authors analyse the interactive influence of energy use, capital investment and finance on pollution in energy-dependent African countries.Design/methodology/approachThe study analyses data from 5 selected energy-dependent African nations (i.e. Algeria, Egypt, Nigeria, Morocco and South Africa) between 1981 and 2020 using the fully modified ordinary least squares (FMOLS) approach.FindingsThe panel result reveals that capital investment and energy interaction and financial development and capital investment moderation reduce pollution in all the countries. However, for country-specific results, the interaction of investment and energy lowers emissions in Algeria, South Africa, Nigeria and Morocco but increases pollution in Egypt. Similarly, except for Egypt, financial development and capital investment interaction offset pollution in Algeria, Nigeria, South Africa and Morocco.Research limitations/implicationsThe limitation of the study stems from the inability to extend the scope to cover the entire African region. However, the fact that the authors selected the most prominent African nations in the sample to enable us to set the template for other smaller nations to follow makes the study tenable in its present form.Practical implicationsEnergy-dependent African countries should invest in eco-friendly machines, technologies and equipment to lower pollution vis-à-vis production expansion.Originality/valueThe present research is more expansive by combining the finance and capital investment channels in the quest for decarbonising emerging African nations. Moreover, this is a comparative study, unlike past studies that mainly deploy a one-size-fits-all approach.
A thorn by any other name: the acceptability of terminology for subtle slights in UK workplaces
Authors: Smith Iain Alexander , Griffiths Amanda 
Published: September 2023

PurposeEmployers are increasingly attempting to mitigate subtle but harmful forms of employee rudeness and slights. These include “microaggressions”, “everyday discrimination” and “workplace incivility”, among others. It is unclear which of these various terms is most acceptable for introducing the topic in the workplace. This paper explores human resources (HR) leaders' considerations about the terms and the organisational context that allow for successful implementation.Design/methodology/approach16 expert interviews were conducted with HR leaders from large organisations in the United Kingdom. Reflexive Thematic Analysis was used to explore interview transcripts.FindingsHR leaders reflected on various terms for subtle slights, largely according to how understandable (coherent) and emotionally resonant (provocative) they appeared. They did not converge on any universally accepted term. Less abstract terms were regarded as most acceptable for a broad audience. There was a view that leaders, often representing dominant groups, would find provocative terms such as microaggressions less acceptable than under-represented groups; the latter would find their experiences of subtle slights validated by terms such as microaggressions. Participants suggested that understanding the need for change was a necessary precursor to participation in training. Compliance-based approaches were considered less helpful. Implications for the design of training initiatives are presented whereby several terms could be used and explained.Originality/valueThis is the first study to gather HR leaders' views on the acceptable terminology for subtle slights. Findings suggest employers may find value in adopting an implementation science approach to introducing diversity initiatives.
Herding and Google search queries in the Brazilian stock market
Authors: Carvalho Jeferson , Jordão da Gama Silva Paulo Vitor , Klotzle Marcelo Cabus 
Published: September 2023

PurposeThis study investigates the presence of herding in the Brazilian stock market between 2012 and 2020 and associates it with the volume of searches on the Google platform.Design/methodology/approachFollowing methodologies are used to investigate the presence of herding: the Cross-Sectional Standard Deviation of Returns (CSSD), the Cross-Sectional Absolute Deviation (CSAD) and the Cross-Sectional Deviation of Asset Betas to the Market.FindingsMost of the models detected herding. In addition, there was a causal relationship between peaks in Google search volumes and the incidence of herding across the whole period, especially in 2015 and 2019.Originality/valueThis study suggests that confirmation bias influences investors' decisions to buy or sell assets.
Own goal or home run? Exploring the implementation of virtual reality training in football and baseball organisations
Authors: Dowsett Ross , Kinrade Noel , Whiteside David , Lawson Dillon , Barnett Cleveland , Magistro Daniele , Wilkins Luke 
Published: September 2023

PurposeDespite the perceived benefits of implementing virtual reality (VR) training in elite sport, arguably the most important element – the perceptions of practitioners – has been largely understudied. Therefore, the present study aims to explore practitioners' perceptions of VR training in elite football and baseball, with a focus on the important factors, obstacles, perceived knowledge and practical use of the technology.Design/methodology/approachA quantitative approach measuring practitioner perceptions via an online questionnaire was adopted. Football respondents (n = 25) represented practitioners from major football leagues across the world, and baseball respondents (n = 15) represented practitioners from Major League Baseball.FindingsBoth football and baseball respondents reported that the most important factor for implementation of VR training was improvement in on-field performance (technical and tactical); whilst cost was viewed as the biggest obstacle. Both football and baseball respondents also noted that the most likely group to receive VR training would be injured and rehabilitating athletes. Mann–Whitney U tests revealed that football respondents perceived coach (p = 0.02) and executive approval (p < 0.001) as significantly greater obstacles than baseball respondents.Originality/valueThis research provides novel and invaluable information for stakeholders within VR regarding what the elite organisations of different sports perceive as the most important factors for implementation, as well as greatest obstacles preventing use. This information should guide future development and marketing of VR training systems in sport.
Mayo Clinic VT calculator: A practical tool for accurate wide complex tachycardia differentiation
Authors: Kashou Anthony H. , LoCoco Sarah , Gardner Matthew R. , Webb Jocelyn , Jentzer Jacob C. , Noseworthy Peter A. , DeSimone Christopher V. , Deshmukh Abhishek J. , Asirvatham Samuel J. , May Adam M. 
Published: September 2023

AbstractThe discrimination of ventricular tachycardia (VT) versus supraventricular wide complex tachycardia (SWCT) via 12‐lead electrocardiogram (ECG) is crucial for achieving appropriate, high‐quality, and cost‐effective care in patients presenting with wide QRS complex tachycardia (WCT). Decades of rigorous research have brought forth an expanding arsenal of applicable manual algorithm methods for differentiating WCTs. However, these algorithms are limited by their heavy reliance on the ECG interpreter for their proper execution. Herein, we introduce the Mayo Clinic ventricular tachycardia calculator (MC‐VTcalc) as a novel generalizable, accurate, and easy‐to‐use means to estimate VT probability independent of ECG interpreter competency. The MC‐VTcalc, through the use of web‐based and mobile device platforms, only requires the entry of computerized measurements (i.e., QRS duration, QRS axis, and T‐wave axis) that are routinely displayed on standard 12‐lead ECG recordings.
Two adjacent implant‐supported restorations in the aesthetic region: A 10‐year prospective case series
Authors: Meijer Henny J. A. , Stellingsma Kees , Vissink Arjan , Raghoebar Gerry M. 
Published: September 2023

AbstractIntroductionThe treatment outcome of two adjacent implant‐supported restorations in the maxillary aesthetic region was assessed regarding peri‐implant soft and hard tissues, and satisfaction during a 10‐year follow‐up period.MethodsTwenty patients missing two adjacent teeth in the maxillary aesthetic region and treated with two implant‐supported restorations were followed prospectively. The patients' clinical and radiographic parameters, as well as their satisfaction, were scored for a 10‐year follow‐up period.ResultsSeventeen patients' data were available for the 10‐year follow‐up. The survival rate of the implants and restorations was 100%. The 10‐year mean peri‐implant bone change at the side facing the adjacent tooth was +0.11 ± 0.57 mm and at the side facing the adjacent implant was −0.08 ± 0.50 mm. The peri‐implant soft tissues were healthy and the patients' satisfaction was high, but the papilla‐index showed compromised inter‐implant papillae and low Pink Esthetic Scores. These figures were of the same magnitude at all time points.ConclusionWhile it is difficult to obtain sufficient inter‐implant papillae and satisfactory Pink Esthetic Scores, the initial treatment results remained stable and the patients were satisfied with the final result throughout the 10‐year follow‐up period.
The bone shielding versus dual‐zone concept in treating thin‐walled fresh extraction sockets with immediate implant placement: Soft and hard tissue changes. A randomized clinical trial
Authors: Elaskary Abdelsalam , Ghallab Noha , Thabet Abdelrahman , Shemais Nesma 
Published: September 2023

AbstractObjectivesTo evaluate the ridge alterations and esthetic outcome 1 year after immediate implant placement using the dual‐zone (DZ) technique versus the bone shielding concept in patients with intact thin‐walled sockets in the esthetic zone.Material and MethodsThis randomized clinical trial included 26 patients with nonrestorable maxillary teeth in the esthetic zone who were randomly assigned to two groups (n = 13 each) to receive immediate implants using either the bone shielding concept or DZ. Definitive restorations were delivered after 2 months. Pink esthetic scores (PESs), vertical soft tissue alterations, and bucco‐palatal ridge dimensional changes were measured and assessed using intra‐oral digital scans at baseline and 1 year post‐procedure. Labial bone thickness was measured using cone beam computed tomography scans at baseline and after 1 year.ResultsThe bone shielding group provided bucco‐palatal ridge thickness stability after 1 year (9.43 mm) compared to baseline values (9.82 mm), while DZ showed a significant loss in the bucco‐palatal ridge thickness after 1 year (7.83) compared to baseline values (9.49). No significant difference was reported in the baseline bucco‐palatal ridge thickness between the two groups (p = 0.6). After 1 year, the bone shielding group demonstrated 0.38 mm ridge shrinkage which was statistically significant (p = 0.0002) compared to 1.67 mm ridge shrinkage in the DZ group. In addition, the average total PES in the bone shielding group was 12.04 versus 10.28 in the DZ group. No significant difference was reported in the mesial papilla length between the DZ and the bone shielding group after 1 year (p > 0.05). However, the midfacial gingival margin (p = 0.026) and distal papilla were significantly higher in the DZ group (p = 0.0025). There was no significant difference in the mean ± SD mm bone gain at the apical level between the two studied groups after 1 year (p = 0.06) showing 0.85 ± 0.23 and 0.64 ± 0.32 mm, respectively. However, the bone shielding concept showed a statistically significant more bone gain mm (p < 0.001) at the (0.56 ± 0.43) and crestal (0.03 ± 0.8) levels after 1 year compared to DZ which revealed 0.18 ± 0.5 and 0.38 ± 0.29 mm bone loss, respectively.ConclusionThe bone shielding concept might offer a reliable alternative for restoring thin‐walled sockets by minimizing postextraction ridge dimensional alterations effect following immediate implant placement in the esthetic zone. Nevertheless, the study suffers from confounding bias since there are two systematic differences between the groups, the barrier membrane type, and the level of bone filling.“This clinical trial was not registered prior to participant recruitment and randomization.” Clinical Trial Registration: NCT05381467.
Achieving conservation through cattle ranching: The case of the Brazilian Pantanal
Authors: Chiaravalloti Rafael Morais , Tomas Walfrido Morais , Akre Tom , Morato Ronaldo Gonçalves , Camilo Andre Restel , Giordano Anthony J. , Leimgruber Peter 
Published: September 2023

AbstractCattle ranching in the ~140,000 km2 Brazilian Pantanal is considered one of the most important cases of sustainable use of natural resources in the global south. The region has had a successful history of balancing environmental protection with the production of >3.8 million cattle. However, global change, infrastructure projects, and deforestation, threaten the sustainable use of the Pantanal. Here, using Ostrom's design principles as a framework, we interviewed 49 local stakeholders and conducted a review of secondary information aiming to evaluate the sustainability of cattle ranching practices across the region and the threats to it. We show that well‐defined property boundaries, congruence between appropriation and provision rules through low‐intensity cattle ranching, and co‐management of resources, are all key components for achieving sustainability in the Pantanal. However, we documented shortcomings in satisfying critical aspects of Orstrom's design principles. Specifically, we argue that the Pantanal needs better biodiversity and behavior monitoring, the creation of platforms or mechanisms to solve local conflicts around resource access and use, recognition by governments and international bodies of the local efforts to promote local sustainability, and the creation of networks effectively connecting existing sustainability initiatives.