bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of cultural brokering in advancing holistic primary care for diabetes and obesity: a participatory qualitative study
Authors: Luig Thea , Ofosu Nicole N , Chiu Yvonne , Wang Nancy , Omar Nasreen , Yip Lydia , Aleba Sarah , Maragang Kiki , Ali Mulki , Dormitorio Irene , Lee Karen K , Yeung Roseanne O , Campbell-Scherer Denise 
Published: September 2023

ObjectivesDiabetes and obesity care for ethnocultural migrant communities is hampered by a lack of understanding of premigration and postmigration stressors and their impact on social and clinical determinants of health within unique cultural contexts. We sought to understand the role of cultural brokering in primary healthcare to enhance chronic disease care for ethnocultural migrant communities.Design and settingParticipatory qualitative descriptive–interpretive study with the Multicultural Health Brokers Cooperative in a Canadian urban centre. Cultural brokers are linguistic and culturally diverse community health workers who bridge cultural distance, support relationships and understanding between providers and patients to improve care outcomes. From 2019 to 2021, we met 16 times to collaborate on research design, analysis and writing.ParticipantsPurposive sampling of 10 cultural brokers representing eight different major local ethnocultural communities. Data include 10 in-depth interviews and two observation sessions analysed deductively and inductively to collaboratively construct themes.ResultsFindings highlight six thematic domains illustrating how cultural brokering enhances holistic primary healthcare. Through family-based relational supports and a trauma-informed care, brokering supports provider–patient interactions. This is achieved through brokers’ (1) embeddedness in community relationships with deep knowledge of culture and life realities of ethnocultural immigrant populations; (2) holistic, contextual knowledge; (3) navigation and support of access to care; (4) cultural interpretation to support health assessment and communication; (5) addressing psychosocial needs and social determinants of health and (6) dedication to follow-up and at-home management practices.ConclusionsCultural brokers can be key partners in the primary care team to support people living with diabetes and/or obesity from ethnocultural immigrant and refugee communities. They enhance and support provider–patient relationships and communication and respond to the complex psychosocial and economic barriers to improve health. Consideration of how to better enable and expand cultural brokering to support chronic disease management in primary care is warranted.
Looking at the fringes of MedTech innovation: a mapping review of horizon scanning and foresight methods
Authors: Garcia Gonzalez-Moral Sonia , Beyer Fiona R , Oyewole Anne O , Richmond Catherine , Wainwright Luke , Craig Dawn 
Published: September 2023

ObjectivesHorizon scanning (HS) is a method used to examine signs of change and may be used in foresight practice. HS methods used for the identification of innovative medicinal products cannot be applied in medical technologies (MedTech) due to differences in development and regulatory processes. The aim of this study is to identify HS and other methodologies used for MedTech foresight in support to healthcare decision-making.MethodA mapping review was performed. We searched bibliographical databases including MEDLINE, Embase, Scopus, Web of Science, IEEE Xplore and Compendex Engineering Village and grey literature sources such as Google, CORE database and the International HTA database. Our searches identified 8888 records. After de-duplication, and manual and automated title, abstracts and full-text screening, 49 papers met the inclusion criteria and were data extracted.ResultsTwenty-five single different methods were identified, often used in combination; of these, only three were novel (appearing only once in the literature). Text mining or artificial intelligence solutions appear as early as 2012, often practised in patent and social media sources. The time horizon used in scanning was not often justified. Some studies regarded experts both as a source and as a method. Literature searching remains one of the most used methods for innovation identification. HS methods were vaguely reported, but often involved consulting with experts and stakeholders.ConclusionHeterogeneous methodologies, sources and time horizons are used for HS and foresight of MedTech innovation with little or no justification provided for their use. This review revealed an array of known methods being used in combination to overcome the limitations posed by single methods. The review also revealed inconsistency in methods reporting, with a lack of any consensus regarding best practice. Greater transparency in methods reporting and consistency in methods use would contribute to increased output quality to support informed timely decision-making.
Protocol for a double-blinded randomised controlled trial to assess the effect of faecal microbiota transplantations on thyroid reserve in patients with subclinical autoimmune hypothyroidism in the Netherlands: the IMITHOT trial
Authors: Fenneman Aline C , Rampanelli Elena , van der Spek Anne H , Fliers Eric , Nieuwdorp Max 
Published: September 2023

BackgroundHashimoto’s thyroiditis (HT) is a common endocrine autoimmune disease affecting roughly 5% of the general population and involves life-long treatment with levothyroxine, as no curative treatment yet exists. Over the past decade, the crosstalk between gut microbiota and the host immune system has been well-recognised, identifying the gut microbiome as an important factor in host health and disease, including susceptibility to autoimmune diseases. Previous observational studies yielded a link between disruption of the gut microbiome composition and HT. This is the first study that investigates the potential of restoring a disrupted gut microbiome with faecal microbiota transplantations (FMTs) to halt disease progression and dampen autoimmunity.Methods and analysisThe IMITHOT trial is a randomised, double-blinded, placebo-controlled study evaluating either autologous or allogenic FMTs in medication-naïve patients with subclinical autoimmune hypothyroidism. In total, 34 patients will be enrolled to receive either three allogenic or autologous FMTs. FMT will be made of fresh stool and directly administered into the duodenum. Patients will be evaluated at baseline before the first FMT is administered and at 6, 12 and 24 months post-intervention to assess efficacy and adverse events. The primary outcome measure will be the net incremental increase (incremental area under the curve) on thyrotropin-stimulated free thyroxine and free triiodothyronine release at 6 and 12 months compared with baseline. Results will be disseminated via peer-reviewed journals and international conferences. The recruitment of the first patient and donor occurred on 18 December 2019.Ethics and disseminationEthics approval was obtained from the hospital Ethics Committee (Medical Ethics Committee) at Amsterdam University Medical Center. The trial’s outcomes offer high-quality evidence that aids in unveiling distinct patterns within the gut microbiota potentially associated with improved thyroid function. Consequently, this may open avenues for the future clinical applications of microbial-targeted therapy in individuals at risk of developing overt HT.Trial registration numberNL7931.
Using co-creation focus groups to customise a remote multidomain programme designed to increase dementia literacy
Authors: Wittich Walter , Kröger Edeltraut , Aubin Gabrielle , Fadhlaoui Asma , Anderson Nicole D , Ben Gaied Nouha , Itzhak Inbal , Belleville Sylvie 
Published: September 2023

ObjectivesTo adapt the content and functionalities ofBrain Health PRO,a web-based multidomain program designed to increase dementia literacy, to the context and needs of users, providers and community organisations across Québec, Canada.DesignFive consecutive qualitative co-creation focus group sessions 30–90 min in duration each, exploring potential barriers and facilitators to usability, accessibility, comprehensibility, participant recruitment and retention.SettingVirtual meetings.ParticipantsA 15-member team based in Québec and Ontario, Canada, consisting of 9 researchers (including a graduate student and the project coordinator), representing occupational therapy, sensory rehabilitation, neuropsychology, psychology, health science and research methods, 3 informal caregivers of older adults living with cognitive decline and 3 members of the Federation of Quebec Alzheimer Societies.Data analysisSession recordings were summarised through both qualitative description and thematic analysis.ResultsThe synthesised recommendations included adjustments around diversity, the complexity and presentation styles of the materials, suggestions on refining the web interface and the measurement approaches; it influenced aspects of participant recruitment, retention efforts and engagement with the content ofBrain Health PRO.ConclusionsCo-creation in dementia prevention research is important because it involves collaboration between researchers, community support and service providers, and persons with lived experience as care providers, in the design and implementation of clinical studies. This approach helps to ensure that the content and presentation of educational material is relevant and meaningful to the target population and those involved in its delivery, and it leads to a greater understanding of their needs and perspectives.
Evaluation of hearing levels and vestibular function and the impact on cognitive performance in (pre)-symptomatic patients with DFNA9: protocol for a prospective longitudinal study (Rosetta study)
Authors: Gommeren Hanne , Moyaert Julie , Bosmans Joyce , Mertens Griet , Cras Patrick , Engelborghs Sebastiaan , Van Ombergen Angelique , Gilles Annick , Van Dam Debby , Van Rompaey Vincent 
Published: September 2023

IntroductionUntreated hearing loss is the largest potentially modifiable risk factor for dementia. Additionally, vestibular dysfunction has been put forward as a potential risk factor for accelerated cognitive decline. Patients with Deafness Autosomal Dominant 9 (DFNA9) present with progressive sensorineural hearing loss and bilateral vestibulopathy and show significantly worse results in cognitive performance compared with a cognitively healthy control group. This highlights the need for adequate treatment to prevent further cognitive decline. This study aims to determine how hearing and vestibular function evolve in (pre-)symptomatic carriers of the p.Pro51Ser mutation in theCOCHgene and how this impacts their cognitive performance and health-related quality of life.Methods and analysisA prospective, longitudinal evaluation of hearing, vestibular function and cognitive performance will be acquired at baseline, 1-year and 2-year follow-up. A total of 40 patients with DFNA9 will be included in the study. The study will be a single-centre study performed at the ORL department at the Antwerp University Hospital (UZA), Belgium. The control group will encompass cognitively healthy subjects, already recruited through the GECkO study. The primary outcome measure will be the Repeatable Battery for the Assessment of Neuropsychological Status adjusted for the Hearing-Impaired total score. Secondary outcome measures include Cortical Auditory-Evoked Potentials, vestibular assessments and health-related quality of life questionnaires. The expected outcomes will aid in the development of gene therapy by providing insight in the optimal time window for the application of gene therapy for the inner ear.Ethics and disseminationThe ethical committee of UZA approved the study protocol on 19 December 2022 (protocol number B3002022000170). All participants have to give written initial informed consent in accordance with the Declaration of Helsinki. Results will be disseminated to the public through conference presentations, lectures and peer-reviewed scientific publications.
Patient-reported outcomes in clinical HIV care: protocol for a single-centre, multistage, mixed-methods study in Denmark
Authors: Borchmann Olivia , Weis Nina , Hansen Ann-Brit Eg , Storgaard Merete , Fetters Michael D , Chandanabhumma P Paul , Moseholm Ellen 
Published: September 2023

IntroductionPeople with HIV-1 (PWH) have worse health-related quality of life (HRQoL) compared with the general population. Using patient-reported outcomes (PROs) may help reorient the focus of HIV care towards improving HRQoL. This study aims to develop, implement and evaluate the use of PROs in HIV care.Methods and analysisThis is a Danish single-centre, multistage mixed-methods study consisting of four substudies (studies I–IV). Study I is a qualitative focus group interview study aiming to identify relevant PRO domains, and barriers and benefits to PRO use. Participants are 5–10 PWH and 5–10 HIV healthcare providers (HCPs). Data are thematically analysed. Results will guide the design of a PRO measure (PROM). Study II is a quantitative study aiming to assess PWH’s willingness and ability to engage with PRO. All PWH are consecutively invited to complete the PROMs before their next consultations. Demographic data are collected at enrolment. Differences between PWH who do/do not complete the PROMs are assessed. Study III is a quantitative before-and-after study aiming to assess the impact of PRO use on HCP awareness. Participants are all who complete the PROMs in Study II. In contrast to study II, HCPs are notified of the PROM results. The number of problems documented by the HCP in patients’ medical records during studies II and III are compared using χ2tests. Multiple regression models are used to identify factors associated with HCP awareness. Study IV is a qualitative study aiming to explore PWH and HCP experiences of using PROs. Participants are 15–20 PWH and 10–15 HCP. Data are collected from participant observation of PRO consultations and individual interviews. Data are analysed thematically.Ethics and disseminationThis study is approved by the Danish Data Protection Agency. Participants will provide written consent prior to participation. Results will be published in peer-reviewed journals.
Comparison of migration rates between traditional and tunneled adductor canal block catheters: a randomized controlled trial
Authors: Gleicher Yehoshua , dos Santos Fernandes Hermann , Peacock Sharon , Alekberli Tural , Di Grazia Vitaliano , Estrellas Regine , Wolfstadt Jesse , Matelski John , Siddiqui Naveed 
Published: September 2023

IntroductionTotal knee arthroplasty is associated with significant postoperative pain. Continuous adductor canal blocks via an inserted adductor canal catheter are effective analgesia interventions with the advantage of decreasing quadriceps weakness and the potential of extending the analgesic effect. The classical adductor canal catheter insertion technique may have a high likelihood of catheter dislodgement out of the canal. The interfascial plane between the sartorius muscle and femoral artery (ISAFE) approach has the potential of decreasing the adductor canal catheter migration. The purpose of this study was to evaluate the incidence of catheter dislodgment to outside the adductor canal, for ISAFE and classical approaches. We hypothesized that ISAFE approach would result in a lower dislodgment rate.MethodsNinety-seven patients for unilateral total knee arthroplasty were included and randomized to either ISAFE intervention group or conventional group. The primary outcome was the incidence of adductor canal catheter dislodged to outside the adductor canal, on ultrasound evaluation, 24 hours after the surgery. Secondary outcomes were pain scores, opioid consumption and continuous adductor canal block related complications for the first 48 hours after surgery.ResultsThe catheters placed using ISAFE approach had a lower rate of dislodgement in comparison to the control group (18.6% vs 44.9%, respectively, p=0.01), at 24 hours after surgery; and lower pain scores for rest, on the first two postoperative days.ConclusionsISAFE group had a significantly lower rate of dislodgement at 24 hours. The continuous adductor canal block analgesic benefit for knee arthroplasty depends on the position of the tip of the catheter inside the adductor canal.
Possible existence of traversable wormhole in Finsler–Randers geometry
Authors: Das Krishna Pada , Debnath Ujjal 
Published: September 2023

AbstractIn the present article, we have explored the possible existence of a traversable wormhole in the framework of Finsler–Randers (F–R) geometry. In order to achieve this goal, first, we have constructed gravitational field equations for static, spherically symmetric spacetime with anisotropic fluid distribution in F–R geometry. Next, we have written the deduced form of field equations in the background of Morris–Thorne wormhole geometry. To visualize the shape of the wormhole, we have selected exponential shape function $$b(r)=\frac{r}{exp\left( \eta \left( \frac{r}{r_{0}} - 1\right) \right) }$$

b

(
r
)

=

r

e
x
p

η

r

r
0

-
1

with the constant parameter $$\eta $$
η
and the throat radius $$r_{0}$$

r
0

and depicted two-dimensional and three-dimensional embedding diagrams corresponding to some considered values of $$\eta $$
η
and $$r_{0}$$

r
0

. Moreover, all essential requirements to build a wormhole shape have been examined for the reported shape function. Next, We have analyzed wormhole configuration for three cases (I, II, III) corresponding to three selected redshift functions. Furthermore, each case is analyzed by dividing it into two models such as (i) Model-1 (for general anisotropic EoS $$p_{t}=\chi p_{r}$$

p
t

=
χ

p
r

) and (ii) Model-2 (for linear phantom-like EoS $$p_{r} + \omega \rho =0$$

p
r

+
ω
ρ
=
0

). In each model of three cases, we have verified the validity of the wormhole solution in F–R geometry by considering null, weak, strong and dominant energy conditions. Also, the total amount of averaged NEC-violating matter near the wormhole throat has been analyzed by computing volume integral quantifier.
Production of excited doubly heavy baryons at the super-Z factory
Authors: Niu Juan-Juan , Li Jing-Bo , Bi Huan-Yu , Ma Hong-Hao 
Published: September 2023

AbstractIn the framework of nonrelativistic QCD, the excited doubly heavy baryons are thoroughly studied via the channel $$e^{+} e^{-}\rightarrow \langle QQ^{\prime }\rangle [n] \rightarrow \Xi _{QQ^{\prime }} +\bar{Q^{\prime }} +{\bar{Q}}$$

e
+

e
-

→

⟨
Q

Q
′

⟩

[
n
]

→

Ξ

Q

Q
′

+

Q
′

¯

+

Q

¯

, which takes place at the collision energy Z-pole. $$Q^{(\prime )}$$

Q

(
′
)

represents b or c quark for the production of $$\Xi _{cc}$$

Ξ

cc

, $$\Xi _{bc}$$

Ξ

bc

, and $$\Xi _{bb}$$

Ξ

bb

, respectively. All of the intermediate diquark states $$\langle QQ'\rangle [n]$$

⟨
Q

Q
′

⟩

[
n
]

in P-wave, $$\langle cc\rangle [^{1}P_{1}]_{{\bar{\textbf{3}}}}$$

⟨
c
c
⟩

[
1

P
1

]

3

¯

, $$\langle cc\rangle [^{3}P_{J}]_{{\textbf{6}}}$$

⟨
c
c
⟩

[
3

P
J

]

6

, $$\langle bc\rangle [^{1}P_{1}]_{{\bar{\textbf{3}}}/ {\textbf{6}}}$$

⟨
b
c
⟩

[
1

P
1

]

3

¯

/
6

, $$\langle bc\rangle [^{3}P_{J}]_{{\bar{\textbf{3}}}/ {\textbf{6}}}$$

⟨
b
c
⟩

[
3

P
J

]

3

¯

/
6

, $$\langle bb \rangle [^{1}P_{1}]_{{\bar{\textbf{3}}}}$$

⟨
b
b
⟩

[
1

P
1

]

3

¯

, and $$\langle bb\rangle [^{3}P_{J}]_{{\textbf{6}}}$$

⟨
b
b
⟩

[
3

P
J

]

6

with $$J=0$$

J
=
0

, 1, or 2, are taken into account. The cross sections and differential distributions, including the transverse momentum, rapidity, angular, and invariant mass, are discussed for the excited baryons production. We find that the contributions of $$\langle cc \rangle $$

⟨
c
c
⟩

, $$\langle bc \rangle $$

⟨
b
c
⟩

, and $$\langle bb \rangle $$

⟨
b
b
⟩

in P-wave are found to be 3.97$$\%$$
%
, 5.08$$\%$$
%
, and 5.89$$\%$$
%
, respectively, compared to S-wave. Supposing that all excited states can decay into the ground state 100%, the total events $$N_{\Xi _{cc}}=8.48 \times 10^{4-6}$$

N

Ξ

cc

=
8.48
×

10

4
-
6

, $$N_{\Xi _{bc}}=2.26\times 10^{5-7}$$

N

Ξ

bc

=
2.26
×

10

5
-
7

, and $$N_{\Xi _{bb}}=4.12 \times 10^{3-5}$$

N

Ξ

bb

=
4.12
×

10

3
-
5

would be produced at the Super-Z Factory with a high luminosity up to $${{\mathcal {L}}} \simeq 10^{34-36}\textrm{cm}^{-2} \textrm{s}^{-1}$$

L
≃

10

34
-
36

cm

-
2

s

-
1

.
The Effects of Hepatogomax Enteral Formula on Systemic Inflammation, Caecum Short-Chain Fatty Acid Levels, and Liver Histopathology in Thioacetamide-Induced Rats
Authors: Purnomo Hery D. , Kusuma Refani A. , Sianturi Elfrida , Haroen Ryan F. , Solichin Muchamad R. , Nissa Choirun , Pramono Adriyan , Mahati Endang , Noer Etika R. 
Published: September 2023

Liver damage characterized by fibrosis and necrosis can worsen the condition of liver disease. Liver disease is associated with impaired immune response and may affect short-chain fatty acid (SCFA) gut metabolites. Hepatogomax enteral formula was developed, which contains brain-chain amino acids (BCAAs) and middle-chain triglycerides (MCTs), which could repair liver tissue damage, improve the inflammatory status, and modulate SCFA in liver damage. The study aimed to determine the effect of hepatogomax on liver tissue repair, inflammation (TNF-α and IL-6), and SCFA levels in thioacetamide (TAA)-induced rats. The induction of TAA causes liver steatosis, increasing TNF-α and IL-6, and decreasing SCFA levels. Hepatogomax at a dose of 14.6 g/200 gBW significantly reduces TNF-α and IL-6 levels and increases SCFA levels (

p

< 0.05). The number of steatosis between groups P2 and P3 was lower as compared to a group of negative control [K2] (

p

< 0.05). Hepatogomax, in a dose-dependent manner, may repair liver tissue and improve inflammatory response and SCFA levels in TAA-induced rats.
Effects of Solid-State Fermentation with the Ganoderma spp. and Coriolus versicolor on the Total Phenol Contents and Antioxidant Properties on Black Soybean
Authors: Li Yanting , Xu Lina , Guo Shang 
Published: September 2023

Aim of this study was to evaluate the influence of solid-state fermentation of 4 strains ((Ganoderma oregonense (GO), Ganoderma lucidum (GL), Ganoderma sinensis (GS), and Coriolus versicolor (CV))) on the nutrients, functional ingredients, and antioxidant activity in black soybean. As a result, after fermentation by 3 strains of Ganoderma spp. and CV, the contents of crude protein, crude fat, reducing sugar, soluble protein, triterpenoid, and total phenol contents in black soybean significantly increased

P

<

0.01

, particularly in CV-black soybean. The contents of crude protein, crude fat, reducing sugar, soluble protein, and total phenol were 122.92%, 132.69%, 290.08%, 122.58%, and 142.47% higher than those of the control groups, respectively. But the total sugar and crude fiber contents decreased significantly

P

<

0.01

. Furthermore, analysis of antioxidant capacity showed that all the fermented products had scavenging effects on DPPH, hydroxyl, and superoxide anion radicals. In addition, the DPPH scavenging ability of CV fermented products was highest, the hydroxyl radical scavenging ability of GS fermented products was highest, and the superoxide anion radical scavenging ability of GO fermented products was highest, which were 9.43, 7.65, and 3.39 folds higher than those of control groups, respectively. All results evidenced that the fermented strains and the fermented time had remarkable influences on the nutritional ingredient and antioxidant activity of fermented products in black soybean. Also, there was a significant correlation between total phenolic content and antioxidant activities. In conclusion, fermented black soybean with fungus has the potential to be developed into a functional food and nutraceutical material.