bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of COVID-19 on the social media practices of orthopaedic surgery residency programs
Authors: Ohnoutka Cole J. , Oladeji Lasun O. , Cherian Nathan J. , Hogan Daniel W. , Crist Brett D. 
Published: February 2023

Background:
Social media is a robust outreach tool that allows programs to outreach with prospective applicants while maintaining social distancing policies. The purpose of this study was to evaluate how the COVID-19 pandemic influenced the social media practices of ACGME accredited orthopaedic surgery residency programs.

Methods:
An analysis of orthopaedic surgery residency social media accounts was performed to identify changes in practices from July 2019 to December 2020. Social media participation was analyzed with respect to program type, location, size, geographical location, and Doximity ranking.

Results:
A total of 194 residency programs were included in this study. Twitter accounts increased from 56 (28.9%) in December 2019 to 87 (44.8%) in January 2021 while Instagram accounts increased from 16 (8.2%) to 107 (55.2%). Allopathic programs, programs with a higher Doximity Reputation Ranking, and those with more than 35 residents were significantly more likely to have an Instagram or Twitter account (P<0.05). There was a significant increase in the average number of Instagram posts per month in July and September 2020 (P<0.05) 2020 as compared to the same period in 2019.

Conclusions:
There was an increase in the prevalence of orthopaedic residency social media accounts during the Covid pandemic. Allopathic programs, programs with a higher Doximity Reputation Ranking, and larger programs were more likely to utilize social media. Social media offers another avenue for programs to communicate with applicants and an increasing number of programs are harnessing this tool to connect with the next generation of orthopaedic surgeons.

Level of Evidence:
Level IV.
Proximal row carpectomy of the wrist in the setting of midcarpal arthritis: Survivorship and associated complications in soft tissue interposition versus capitate resurfacing
Authors: Cheng Christopher , Acuña Alexander J. , Wang Joanne H. , Malone Kevin J. 
Published: February 2023

Background:
Proximal row carpectomy (PRC) has been shown to be an effective treatment option for early stages of wrist arthritis. In the presence of midcarpal arthritis however, PRC has generally been contraindicated due to a high conversion rate to total wrist arthrodesis. Variations to PRC, including radio-capitate soft tissue interposition and capitate resurfacing, have been introduced to delay conversion and have demonstrated similar outcomes compared to standard PRC. Comparative outcomes between these technical variations have not been investigated however.

Methods:
Retrospective chart review was conducted for patients who underwent PRC with interposition or capitate resurfacing from 2009-2019. Patient demographics, pre- and post-operative range of motion, operative time, cost, and post-operative complications were collected. Descriptive statistics were expressed as means and standard deviations. Survivability was plotted on a Kaplan-Meier survival curve.

Results:
Final cohorts included ten patients who underwent PRC with interposition and six who underwent PRC with resurfacing. Resurfacing had longer average operative duration (51.3±18.3 vs. 79.0±16.5 min, P=0.009) and higher cost ($29,116±10,036 vs. $15,290±3,743, P=0.028). There was no significant difference in wrist ROM. Two of the six patients who underwent resurfacing experience complications requiring conversion to total wrist arthrodesis, however there was no significant difference in overall survivorship.

Conclusions:
In this observational comparative study, PRC with capitate resurfacing trended towards longer operative time, increased cost, and higher complication and conversion rate. Future larger and more standardized analyses are needed in order to evaluate the long-term outcomes of these procedures.

Level of Evidence:
Level IV – Case Series.
Persistently Elevated Soluble Triggering Receptor Expressed on Myeloid Cells 1 and Decreased Monocyte Human Leucocyte Antigen DR Expression Are Associated With Nosocomial Infections in Septic Shock Patients
Authors: Venet Matthieu , Bidar Frank , Derive Marc , Delwarde Benjamin , Monard Céline , Hengy Baptiste , Jolly Lucie , Rimmelé Thomas , Lukaszewicz Anne-Claire , Monneret Guillaume , Venet Fabienne 
Published: February 2023

OBJECTIVES:Sepsis-acquired immunosuppression may play a major role in patients’ prognosis through increased risk of secondary infections. Triggering receptor expressed on myeloid cells 1 (TREM-1) is an innate immune receptor involved in cellular activation. Its soluble form (sTREM-1) has been described as a robust marker of mortality in sepsis. The objective of this study was to evaluate its association with the occurrence of nosocomial infections alone or in combination with human leucocyte antigen-DR on monocytes (mHLA-DR).DESIGN:Observational study.SETTING:University Hospital in France.PATIENTS:One hundred sixteen adult septic shock patients as a post hoc study from the IMMUNOSEPSIS cohort (NCT04067674).INTERVENTIONS:None.MEASUREMENTS AND MAIN RESULTS:Plasma sTREM-1 and monocyte HLA-DR were measured at day 1 or 2 (D1/D2), D3/D4, and D6/D8 after admission. Associations with nosocomial infection were evaluated through multivariable analyses. At D6/D8, both markers were combined, and association with increased risk of nosocomial infection was evaluated in the subgroup of patients with most deregulated markers in a multivariable analysis with death as a competing risk. Significantly decreased mHLA-DR at D6/D8 and increased sTREM-1 concentrations were measured at all time points in nonsurvivors compared with survivors. Decreased mHLA-DR at D6/D8 was significantly associated with increased risk of secondary infections after adjustment for clinical parameters with a subdistribution hazard ratio of 3.61 (95% CI, 1.39–9.34;p= 0.008). At D6/D8, patients with persistently high sTREM-1 and decreased mHLA-DR presented with a significantly increased risk of infection (60%) compared with other patients (15.7%). This association remained significant in the multivariable model (subdistribution hazard ratio [95% CI], 4.65 [1.98–10.9];p< 0.001).CONCLUSIONS:In addition to its prognostic interest on mortality, sTREM-1, when combined with mHLA-DR, may help to better identify immunosuppressed patients at risk of nosocomial infections.
Interventional Pulmonology Productivity, Compensation, and Practice Benchmarks
Authors: Wahidi Momen M. , Lamb Carla R. , Kovitz Kevin , Keyes Colleen , Bechara Rabih , Giovacchini Coral X. , French Kim , Shojaee Samira , Musani Ali , Eapen George , Ost David E. 
Published: February 2023

Background:
Interventional pulmonology (IP) is a growing field that has not yet been recognized by the American Board of Medical Specialties or incorporated into national benchmark organizations. As a result, there is a lack of data on IP practice patterns, physicians’ compensation and productivity targets.

Methods:
We sent an anonymous survey to 647 current or past physician members of the AABIP. Domains included demographics, training background, academic rank, practice settings, work relative value unit (wRVU) targets, salary, and career satisfaction.

Results:
The response rate to the survey was 28.3%; 17.8% were female. The median salary for IP faculty in academic institutions was $320,000 for assistant professors, $338,000 for associate professors, and $350,000 for full professors. Salaries were lower for women than for men in academic practice, even after adjusting for the number of years in practice (mean salary difference after adjustment $57,175, 95% CI: $19,585-$94,764, P=0.003). The median salary for private practice was higher at $428,000. Among respondents that used wRVU targets, the median targets for academic and private practice were 5500 and 6300, respectively. The majority of IP physicians are satisfied with their career choice.

Conclusions:
Productivity targets in IP are used less than half the time, and when they are used, they are set in line with the lower wRVU of IP procedures. IP compensation is higher than that of general pulmonary medicine, as reported by national benchmark associations. In academic practices, gender differences in salaries were found.
Hypoalbuminemia and colorectal cancer patients: Any correlation?: A systematic review and meta-analysis
Authors: Christina Natalia Maria , Tjahyanto Teddy , Lie Jason Gunawan , Santoso Tiffanie Almas , Albertus Hans , Octavianus Daniel , Putri Derby Ayudhia Utami Iskandar , Andrew Johanes , Jatinugroho Yusuf Damar , Shiady Christian , Wijaya Jeremiah Hilkiah 
Published: February 2023

Background:
In malnourished patients with colorectal cancer, hypoalbuminemia is common and was proposed to determine the postoperative outcome of colorectal surgery. Mounting articles published but have not been evaluated. We aim to assess the predictive value of preoperative hypoalbuminemia in patients undergoing colorectal surgery.

Methods:
We performed a literature search from PubMed, Euro PMC, and Cochrane with the terms serum albumin, hypoalbuminemia, prognosis, outcome, colorectal cancer, and neoplasm. We also hand-searched and included any relevant papers. Hypoalbuminemia is defined as plasma albumin level < 3.5 mg/dL. We restricted the included studies to English language and adults undergoing colectomy, laparotomy, laparoscopy, or abdominoperineal resection. Any types of articles were included, except an abstract-only publication and those that did not report the key exposure or outcome of interest. The key exposures were mortality, hospitalization time, and morbid conditions (thrombosis, surgical site infection, sepsis, and wound events). We pooled the odds ratio from each included literature as effect size. The Newcastle Ottawa scale and GRADE were used to determine the quality of each included study.

Results:
Hereof 7 observational studies (236,480 individuals) were included. Our meta-analysis found that preoperative hypoalbuminemia can predict the postoperative outcome in colorectal cancer patients. Individuals with hypoalbuminemia were not associated with 30-day mortality (risk ratio [RR] 2.05 [0.72, 5.86], P = .18, I
2 = 99%) but were associated with morbidity (RR 2.28 [1.78, 2.93], P < .00001, I
2 = 87.5%), surgical complication (RR 1.69 [1.34, 2.13], P < .00001, I
2 = 98%), and hospitalization (RR 2.21 [1.93, 2.52], P < .00001, I
2 = 0%). According to newcastle ottawa scale, the included studies are of moderate to sound quality.

Conclusions:
The current systematic review and meta-analysis showed that preoperative hypoalbuminemia was significantly associated with morbidity, length of stay, and surgical complication but not mortality.
An algorithmic approach of reconstruction for cranioplasty failure: A case series
Authors: Wang Yu-Chi , Wu Yi-Chia , Chang Chao-Wei , Chung Chia-Li , Lee Su-Shin 
Published: February 2023

Rationale:
Cranioplasty is a surgical procedure used to repair cranial defects for both cosmetic and functional reasons. The complication rate of cranioplasty is between 10% and 50%. The failure of cranioplasty is associated with various factors, including etiologies, types of material, and the timing of cranioplasty. In this study, a case series of managing cranioplasty complications at a single institution.

Patient concerns:
Eighteen patients were identified who underwent craniofacial defect reconstruction due to the failure of their initial cranioplasty between January 2010 and May 2020. Five men (27.78%) and thirteen women (72.22%) were included. The mean age was 39.61 years old. The average follow-up duration was 5.94 years.

Diagnoses:
The indication for initial cranioplasty included previous decompressive craniectomy (77.78%, n = 14), traumatic cranial defects (16.67%, n = 3), and congenital cranial deformity (5.56%, n = 1). The reported complications were infection (50%, n = 9), implant exposure (50%, n = 9), wound dehiscence (22.22%, n = 4) and cranial deformity (11.11%, n = 2).

Interventions:
More than half of the materials used for initial cranioplasty were synthetic [titanium mesh: 44.44%, n = 8; polymethyl metacrylate: 5.56%, n = 1; titanium mesh and polymethyl metacrylate: 5.56%, n = 1], while 44.44% of the patients received autologous bone graft.

Outcomes:
Of all reconstructive procedures for cranioplasty failure, 55.56% was local flap with or without skin graft (n = 10), 16.67% was free flap (n = 3), 11.11% was skin graft only (n = 2), 5.56% was regional flap (n = 1). The free flap survival rate was 100% (3/3), and implant removal with sebsquent second cranioplasty was performed on 27.78% (n = 5) of the patients.

Lessons:
Management of cranioplasty failure can be challenging due to infection, refractory implant exposure, and wound dehiscence. The principles of management are based on adequate infection control and reconstructive ladder. Meanwhile, collaboration with plastic surgery and neurosurgery should be strengthened in order to achieve the best clinical outcomes.
Full recovery of lung tissue after severe viral pneumonia H1N1: A case report with 10 years follow-up
Authors: Kočan Ladislav , Firment Jozef , Pirníková Ingrid , Farkašová Iannaccone Silvia , Rybár Dušan , Gnoriková Juliána , Korček Ján , Kočanová Hana , Török Pavol , Rapčanová Simona , Vašková Janka 
Published: February 2023

Rationale:
World healthcare frequently faced severe viral pneumonia cases in the last decades, due to pandemic situations such as H1N1, MERS-CoV, and SARS-COVID-19.

Patient concerns:
The impact of viral infection on lung structure, lung function, and overall mortality was significant. The quality of life and assumed life expectancy was decreased with the supposed development of lung fibrosis in involved survived patients.

Diagnoses:
We described the course and treatment of severe pneumonia H1N1 in a 30-year-old patient.

Interventions:
Patient was included in a study regarding the therapeutic efficacy of selenium ClinicalTrials.gov ID: NCT02026856 with 10 years follow-up with concurrently documented X-ray lung examinations and final histology of lung tissue after sudden death.

Outcomes:
All sequential examinations and histological findings show a healing trend with the final full recovery of lung tissue.
3D reconstruction of a gallbladder duplication to guide LC: A case report and literature review
Authors: Ye Yong Qing , Liang Qing , Li En Ze , Gong Jing Lin , Fan Jing Ming , Wang Ping 
Published: February 2023

Rationale:
Gallbladder duplication is a congenital aberration of the biliary tree, which is rarely encountered in the abdomen. It is a challenge that can be encountered by surgeons and is associated with an increased risk of complications after cholecystectomy. More than 50% of gallbladder duplication cases were undetected on preoperative traditional imaging. In this study, a case of gallbladder duplication in a patient with mild abdominal pain detected using preoperative 3-dimensional (3D) reconstruction of the gallbladder was described for the first time.

Patient concerns and diagnosis:
We present a case of gallbladder duplication in a 32-year-old man who was referred to our hospital for recurrent right upper quadrant abdominal pain without any other significant history.

Interventions and outcomes:
He underwent a 3D reconstruction technique as a supplement for gallbladder duplication that could not be diagnosed using magnetic resonance cholangiopancreatography or other traditional tools. Compared with other diagnostic tools, 3D reconstruction is more visual and accurate for diagnosing gallbladder duplication and guiding laparoscopic cholecystectomy without ductal injuries or other complications.

Conclusion:
Gallbladder duplication is an extremely rare biliary anatomical anomaly; failure to recognize it perioperatively exposes the patient to an increased risk of bile duct injuries. We review 28 cases of missed gallbladder duplication and conclude that less 50% of gallbladder duplication cases were detected via preoperative traditional imaging. We present a case and find that the 3D reconstruction technique can be used as a supplement for gallbladder duplication that could not be diagnosed by using magnetic resonance cholangiopancreatography or other tools. The value of using 3D reconstruction of gallbladder duplication is feasible and innovative, and facilitates guiding to laparoscopic cholecystectomy.
Acupuncture for children with autism spectrum disorder: A systematic review and meta-analysis
Authors: Lun Tingting , Lin Shaoping , Chen Yuecai , Zhao Yunxuan , Wang Dexin , Li Li , Yu Jin 
Published: February 2023

Background:
The aim of this study was to assess the efficiency and safety of acupuncture in core symptomatic improvement of children with autism spectrum disorder (ASD).

Methods:
We searched the following databases: Cochrane Library, PubMed, Embase, Medline, China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Science and Technology Periodical (VIP) and Chinese Biological Medicine (CBM), from 1 January 2012 to 25 September 2022. The Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), and Autism Treatment Evaluation Checklist (ATEC) were adopted as outcome indicators. Three reviewers independently assessed the risk of bias (ROB) and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE)assessment. Utilizing Review Manager (RevMan) 5.3 and Stata 12.0, data were analyzed.

Results:
A total of 38 trials were included, and 2862 participants participated in qualitative synthesis and meta-analysis. Only 1 trial was assessed as having a low ROB, and 37 trials were assessed as having an overall high ROB. The quality of evidence for most indicators were considered very low by the GRADE criteria. The results showed that acupuncture groups might have a higher clinical effective rate than nonacupuncture groups (relative risk [RR] = 1.33,95% confidence interval [CI] = 1.25–1.41; heterogeneity: x
2=18.15, P = .64, I
2 = 0%). Regarding changes in ABC scores, the acupuncture groups might exhibit greater decrease than nonacupuncture groups (MMD = −6.06, 95%CI = −7.25 to −4.87, P < .00001; heterogeneity: x
2 =73.37, P = .03, I
2 = 77%). In terms of changes in CARS score, acupuncture group may benefit more than nonacupuncture group (MMD = −3.93, 95%CI = 4.90 to −2.95, P < .00001; heterogeneity: x
2=234.47, P < .00001, I
2 = 90%). Additionally, in terms of ATEC score, acupuncture groups showed more benefit than nonacupuncture groups (MMD = −10.24, 95%CI = −13.09 to −7.38, P < .00001; heterogeneity: x
2=45.74, P = .04, I
2 = 85%). Both subgroup analysis and sensitivity analysis are existing heterogeneity. Only 1 RCT study involved adverse events with mild symptoms that did not interfere with treatment and evaluation.

Conclusion:
Children with ASD may benefit from acupuncture because of its effectiveness and safety. Nevertheless, given the low quality of the evidence for the assessed outcomes and the high ROB of analyzed trials, the results should be regarded with caution.
Diffuse large B cell lymphoma CD5-positive arising in an immune deficiency and immune dysregulation setting: A case report and brief review of the literature
Authors: Cristian Miruna , Baz Radu Andrei , Stoica Andreea Georgiana , Așchie Mariana , Ghinea Maria Mihaela , Deacu Mariana , Boșoteanu Madalina , Mitroi Anca Florentina , Dobrin Nicolae , Iordache Ionut Eduard , Bălțătescu Gabriela Izabela 
Published: February 2023

Rationale:
In the era of antiretroviral therapy, lymphoma is the primary cause of cancer-related death among human immunodeficiency virus (HIV)-infected people and the most prevalent and aggressive non-Hodgkin lymphoma is diffuse large B cell lymphoma, which usually has an aggressive clinical course. CD5-positive diffuse large B cell lymphoma (DLBCL) is an insufficiently studied, relatively new entity, which accounts for 5% to 10% of the DLBCL population. The current study presents the clinicopathological features, diagnostic approach, and clinical outcomes of this HIV-related lymphoma and highlights the importance of the early diagnosis of CD5-positive DLBCL.

Patient concerns:
We present a case of a 30-year-old male patient, with a medical history of HIV-positive serology and antiviral treatment, presenting with diffuse abdominal pain and symptoms related to obstruction or perforation, followed by exploratory laparotomy and surgical resection of the small intestine with other areas of involvement. The surgical specimen was morphologically evaluated and immunohistochemical stained.

Diagnoses and Interventions:
Histopathologic examination revealed a diffuse neoplastic proliferation of large B lymphocytes within the small intestine, lacking features of other defined types of large B cell lymphoma. The diagnosis of CD5-positive DLBCL subtype was made after immunostaining with twelve monoclonal antibodies (CD3, CD5, CD10, CD20, CD23, CD30, CD68, Cyclin D1, MUM1, Bcl2, Bcl6, and Ki-67). The expression profile of immunohistochemical markers (CD10, Bcl6, and MUM1) established the cell of origin of this case of DLBCL by using the Hans algorithm.

Lessons:
The current report highlights the importance of early diagnosis of CD5-positive DLBCL because of its poor prognosis and calls attention to the critical importance to identify immunodeficiencies because doing so affects the types of treatments available. Although cell-of-origin is useful for predicting outcomes, the germinal center B cell like and activated-B cell like subtypes remain heterogeneous, with better, and worse prognostic subsets within each group.
Evaluation of efficacy and safety of lascufloxacin for nursing and healthcare associated pneumonia: single-arm, open-label clinical trial: A study protocol
Authors: Hosogaya Naoki , Takazono Takahiro , Ota Kenji , Kiya Rieko , Shirai Yumi , Kawasaki Rina , Yano Hiroshi , Morimoto Shinpei , Nakao Rumiko , Kanamaru Yumiko , Yoshino Yukari , Ishikawa Yasuyuki , Fukushima Chizu , Yamamoto Hiroshi , Izumikawa Koichi , Yanagihara Katsunori , Mukae Hiroshi 
Published: February 2023

Background:
Lascufloxacin hydrochloride (LSFX) is a quinolone antibiotic that inhibits DNA gyrase and topoisomerase IV of bacteria, it is anticipated to minimize antibiotic resistance in bacteria. It exhibits antibacterial activity against a relatively wide range of bacterial species, including anaerobic bacteria, and its efficacy and safety against community-acquired pneumonia have been shown; however, its efficacy and safety against nursing and healthcare associated pneumonia (NHCAP) have not been verified.

Methods/Design:
Here, a single-arm, open-label, uncontrolled study was conducted in which LSFX was administered to patients with NHCAP at 24 facilities. The research subjects (77 cases) were orally administered 75 mg of LSFX once a day for 7 days. The primary endpoint was the clinical efficacy at the time of test of cure (TOC) (TOC; 5–10 days after the end of LSFX administration), while the secondary endpoints were the efficacy at the time of end of treatment, early clinical efficacy, microbiological efficacy at the time of TOC and end of treatment, and safety evaluation of LSFX.

Discussion:
NHCAP is a common pneumonia in clinical settings and a notable pneumonia whose mortality is high compared to community-acquired pneumonia. The present study showed the efficacy and safety of LSFX against NHCAP, which could lead to a larger number of therapeutic options for NHCAP.