bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Condylar metastasis from hepatocellular carcinoma: An uncommon case report and literature review
Authors: Liu Xiaojie , Liu Yanshan , Sun Jian , Li Ningyi , Fan Cunhui , Chen Liqiang 
Published: January 2023

BackgroundPatients with hepatocellular carcinoma are often affected by metastases, but condylar metastasis is particularly rare.Case presentationA 51-year-old man with a history of hepatocellular carcinoma requested treatment for facial pain. Computed tomography indicated that the condylar bone has been destroyed and fractured. Pathology confirmed condylar metastasis from hepatocellular carcinoma. Complete metastasectomy and condylar reconstruction were performed to preserve his facial appearance. No local recurrence or distant metastasis was found at 8 months of follow-up.ConclusionThe condyle can be a metastatic site of hepatocellular carcinoma, regardless of its rarity. Long-term comprehensive surveillance and follow-up are needed for patients with hepatocellular carcinoma. The presence of solitary mass does exclude the possibility of metastatic cancer for these patients, and postoperative imaging and pathological diagnosis are important to determine its origin. If patients’ physical condition permits, the mass can be completely excised, and the physiological function can be restored and reconstructed.
RETRACTED: Barriers and facilitators of childhood obesity prevention policies: A systematic review and meta-synthesis
Authors: Taghizadeh Shahnaz , Hashemi Mohamad Ghazanfari , Zarnag Rahim Khodayari , Fayyazishishavan Ehsan , Gholami Marjan , Farhangi Mahdieh Abbasalizad , Gojani Leila Jahanbazi 
Published: January 2023

ObjectivesChildhood obesity is one of the worldwide considerable public health challenges and many factors can play a role in its management. Therefore, this article examined the facilitators and barriers of childhood obesity prevention (COP) policies.MethodsThis systematic review of qualitative studies was conducted via a search of the SCOPUS, PubMed, and Google Scholar databases between 1 January 2010 and 11 February 2022 and examined factors that influence the implementation of COP policies at a community approach.ResultsThe parents' reluctance to engage in COP activities, lack of sufficient knowledge, and financial problems were the most reported barriers at the individual level. In addition, the beliefs about COP at the sociocultural level and limited funding and resources, time limitations in stakeholders at the implementation level, and lack of policy support at the structural level were the most frequently reported barriers. Further, effective communication between stakeholders and parents and school staff at the sociocultural level and flexibility of the intervention, delivery of healthy food programs in schools, low-cost and appropriate resources, and the availability of appropriate facilities are the most frequently reported facilitators in the structural level.ConclusionIndividual, sociocultural, and structural level-related barriers and facilitators influence the implementation of COP policies. Most of the barriers and facilitators in this systematic review were related to the structural level.
A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells
Authors: Sato Kakeru , Seki Tatsuya , Mizutani Asuka , Muranaka Yuka , Hirota Shiho , Nishi Kodai , Yamazaki Kana , Nishii Ryuichi , Nakanishi Takeo , Tamai Ikumi , Kawai Keiichi , Kobayashi Masato 
Published: January 2023

Chemoradiotherapy is frequently used to treat cancer. Stereotactic body radiotherapy (SBRT) is a single high-dose radiotherapy used to treat a variety of cancers. The anticancer drug methotrexate (MTX) shows affinity for solute carrier (SLC) and ATP-binding cassette (ABC) transporters. This study investigated relationships between accumulation of methotrexate and gene expression levels of solute carrier and ATP-binding cassette transporters in cancer cells after a single and high-dose X-ray irradiation. Cancer cell lines were selected from lung and cervical cancer cell line that are commonly used for stereotactic body radiotherapy and effective with methotrexate. We examined expression levels of organic anion-transporting polypeptide (OATP)1B1, OATP1B3, OATP1B7, and organic anion transporter (OAT)1 as solute carrier transporters and multidrug resistance-associated protein (MRP)1 and MRP2 as ATP-binding cassette transporters, using real-time polymerase chain reaction and accumulation of 3H-MTX in cancer cells after 10-Gy irradiation, assuming stereotactic body radiotherapy. Cells were divided into three groups: Control without irradiation; 4 h after irradiation; and 24 h after irradiation. In control, gene expression levels of OAT1 in all cells was below the limit of measurement. After irradiation, gene expression levels of OATP1B1/1B3/1B7 showed changes in each cell line. Gene expression levels of MRP1/2 tended to increase after irradiation. Gene expression levels of OATP1B1/1B3/1B7 were much lower than those of MRP1/2. Accumulation of 3H-MTX tended to decrease over time after irradiation. Irradiation of cancer cells thus alters gene expression levels of both solute carrier transporters (OATP1B1/1B3/1B7) and ABC transporters (MRP1/2) and decreases accumulation of 3H-MTX in cancer cells over time due to elevated expression of MRP1/2.
Miracle fruit seed as a potential supplement for the treatment of learning and memory disorders in Alzheimer’s disease
Authors: Huang Xue-Yan , Xue Lu-Lu , Chen Ting-Bao , Huangfu Li-Ren , Wang Ting-Hua , Xiong Liu-Lin , Yu Chang-Yin 
Published: January 2023

Currently, the treatment of Alzheimer’s disease (AD) is still at the stage of symptomatic treatment due to lack of effective drugs. The research on miracle fruit seeds (MFSs) has focused on lipid-lowering and antidiabetic effects, but no therapeutic effects have been reported in AD. The purpose of this study was to provide data resources and a potential drug for treatment of AD. An AD mouse model was established and treated with MFSs for 1 month. The Morris water maze test was used to assess learning memory function in mice. Nissl staining was used to demonstrate histopathological changes. MFSs were found to have therapeutic implications in the AD mouse model, as evidenced by improved learning memory function and an increase in surviving neurons. To explore the mechanism of MFSs in treating AD, network pharmacological approaches, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and molecular docking studies were carried out. Based on the network pharmacology strategy, 74 components from MFS corresponded to 293 targets related to the AD pathology. Among these targets, AKT1, MAPK3, ESR1, PPARG, PTGS2, EGFR, PPARA, CNR1, ABCB1, and MAPT were identified as the core targets. According to the relevant number of core targets, cis-8-octadecenoic acid, cis-10-octadecenoic acid, 2-dodecenal, and tetradecane are likely to be highly correlated with MFS for AD. Enrichment analysis indicated the common targets mainly enriched in AD and the neurodegeneration-multiple disease signaling pathway. The molecular docking predictions showed that MFSs were stably bound to core targets, specifically AKT1, EGFR, ESR1, PPARA, and PPARG. MFSs may play a therapeutic role in AD by affecting the insulin signaling pathway and the Wnt pathway. The findings of this study provide potential possibilities and drug candidates for the treatment of AD.
Salicylic acid delays pear fruit senescence by playing an antagonistic role toward ethylene, auxin, and glucose in regulating the expression of PpEIN3a
Authors: Xu Yue , Huo Liyue , Zhao Keke , Li Yawei , Zhao Xinran , Wang Huiying , Wang Wenli , Shi Haiyan 
Published: January 2023

Salicylic acid (SA) and ethylene (ET) are crucial fruit senescence hormones. SA inhibited ET biosynthesis. However, the mechanism of SA delaying fruit senescence is less known. ETHYLENE INSENSITIVE 3 (EIN3), a key positive switch in ET perception, functions as a transcriptional activator and binds to the primary ET response element that is present in the promoter of the ETHYLENE RESPONSE FACTOR1 gene. In this study, a gene encoding putative EIN3 protein was cloned from sand pear and designated as PpEIN3a. The deduced PpEIN3a contains a conserved EIN3 domain. The evolutionary analysis results indicated that PpEIN3a belonged to the EIN3 superfamily. Real-time quantitative PCR analysis revealed that the accumulation of PpEIN3a transcripts were detected in all tissues of this pear. Moreover, PpEIN3a expression was regulated during fruit development. Interestingly, the expression of PpEIN3a was downregulated by SA but upregulated by ET, auxin, and glucose. Additionally, the contents of free and conjugated SA were higher than those of the control after SA treatment. While the content of ET and auxin (indole-3-acetic acid, IAA) dramatically decreased after SA treatment compared with control during fruit senescence. The content of glucose increased when fruit were treated by SA for 12 h and then there were no differences between SA treatment and control fruit during the shelf life. SA also delayed the decrease in sand pear (Pyrus pyrifolia Nakai. ‘Whangkeumbae’) fruit firmness. The soluble solid content remained relatively stable between the SA treated and control fruits. This study showed that SA plays an antagonistic role toward ET, auxin, and glucose in regulating the expression of PpEIN3a to delay fruit senescence.
Segmented relations between online reading behaviors, text properties, and reader–text interactions: An eye-movement experiment
Authors: Gong Tao , Shuai Lan 
Published: January 2023

PurposeTo investigate relations between abilities of readers and properties of words during online sentence reading, we conducted a sentence reading eye-movements study on young adults of English monolinguals from the US, who exhibited a wide scope of individual differences in standard measures of language and literacy skills.MethodWe adopted mixed-effects regression models of gaze measures of early and late print processing stages from sentence onset to investigate possible associations between gaze measures, text properties, and skill measures. We also applied segmented linear regressions to detect the dynamics of identified associations.ResultsOur study reported significant associations between (a) gaze measures (first-pass reading time, total reading times, and first-pass regression probability) and (b) interactions of lexical properties (word length or position) and skill measures (vocabulary, oral reading fluency, decoding, and verbal working memory), and confirmed a segmented linear dynamics between gaze measures and lexical properties, which was influenced by skill measures.ConclusionThis study extends the previous work on predictive effects of individual language and literacy skills on online reading behavior, enriches the existing methodology exploring the dynamics of associations between lexical properties and eye-movement measures, and stimulates future work investigating factors that shape such dynamics.
Workplace discrimination and its relationship with organizational commitment among the surgical technologist: A national cross-sectional study in Iran
Authors: Teymoori Esmaeil , Shahkarami Negar , Ghanavati Maryam , Maleki Zahra , Fereidouni Armin 
Published: January 2023

BackgroundDiscrimination in healthcare centers can reduce care quality and job satisfaction, weaken the morale of the personnel and increase the cost of health care and finally lead to turnover intention. Discrimination in hospitals can affect the work outcomes and performance indicators of nurses such as their organizational commitment. Due to the vital role of surgical technologists in surgery and justice as the basis of effective performance, as well as the role of organizational commitment in care quality, the present study was conducted aimed to determine the level of workplace discrimination from viewpoint of the surgical technologists and its relationship with the organizational commitment.MethodsThis cross-sectional study was conducted on 615 surgical technologists in 8 metropolises of Iran in 2022. The sampling method in this study was multi-stage. The data collection tools included three questionnaires (demographic information, workplace discrimination, and Allen and Meyer’s organizational commitment). Data were collected within 2 months and analyzed by SPSS version 22. Descriptive and inferential analyzes including independent t-test and analysis of variance were used for data analysis. p-value ≥ 0.05 was considered significant.ResultsThe average age of the participants in the study were 29.90 ± 5.83 years with the participation of 464 women. The results of the data analysis showed an inverse and significant correlation between workplace discrimination and organizational commitment (r = −0.149, p-value &lt; 0.001). The mean and standard deviation for workplace discrimination was 108.20 ± 11.53, which is average. Also, the mean and standard deviation for total organizational commitment was 100.56 ± 19.14, which is higher than the average.ConclusionAccording to the results of this study, managers need to pay attention to reduce discrimination in the operating room and establish organizational justice, to improve the motivation of surgical technologists and the quality of their performance. It is also suggested that operating room managers and supervisors, by creating a safe, confidential, and fearless environment to encourage the personnel to express what they understand about discriminatory conditions.
Distinguishing different types of attention deficit hyperactivity disorder in children using artificial neural network with clinical intelligent test
Authors: Lin I-Cheng , Chang Shen-Chieh , Huang Yu-Jui , Kuo Terry B. J. , Chiu Hung-Wen 
Published: January 2023

BackgroundAttention deficit hyperactivity disorder (ADHD) is a well-studied topic in child and adolescent psychiatry. ADHD diagnosis relies on information from an assessment scale used by teachers and parents and psychological assessment by physicians; however, the assessment results can be inconsistent.PurposeTo construct models that automatically distinguish between children with predominantly inattentive-type ADHD (ADHD-I), with combined-type ADHD (ADHD-C), and without ADHD.MethodsClinical records with age 6–17 years-old, for January 2011–September 2020 were collected from local general hospitals in northern Taiwan; the data were based on the SNAP-IV scale, the second and third editions of Conners’ Continuous Performance Test (CPT), and various intelligence tests. This study used an artificial neural network to construct the models. In addition, k-fold cross-validation was applied to ensure the consistency of the machine learning results.ResultsWe collected 328 records using CPT-3 and 239 records using CPT-2. With regard to distinguishing between ADHD-I and ADHD-C, a combination of demographic information, SNAP-IV scale results, and CPT-2 results yielded overall accuracies of 88.75 and 85.56% in the training and testing sets, respectively. The replacement of CPT-2 with CPT-3 results in this model yielded an overall accuracy of 90.46% in the training set and 89.44% in the testing set. With regard to distinguishing between ADHD-I, ADHD-C, and the absence of ADHD, a combination of demographic information, SNAP-IV scale results, and CPT-2 results yielded overall accuracies of 86.74 and 77.43% in the training and testing sets, respectively.ConclusionThis proposed model distinguished between the ADHD-I and ADHD-C groups with 85–90% accuracy, and it distinguished between the ADHD-I, ADHD-C, and control groups with 77–86% accuracy. The machine learning model helps clinicians identify patients with ADHD in a timely manner.
Social media use as a coping mechanism during the COVID-19 pandemic: A multidimensional perspective on adolescents' well-being
Authors: Maftei Alexandra , Merlici Ioan-Alex , Dănilă Oana 
Published: January 2023

IntroductionSocial media use was previously characterized as both a maladaptive coping mechanism, and a source of engagement with peers, suggesting an ambivalent effect. The present study explored how adolescents might use social media as a coping mechanism during the COVID-19 pandemic, using a multidimensional perspective on well-being.MethodsOur sample consisted of 259 Romanian teenagers aged 11–16 (M = 13.38, SD = 0.93, 57% males). We investigated the potential indirect effect of social media use, i.e., its cognitive, affective, and behavioral dimensions on the relationship between depressive symptoms and adolescents' well-being.ResultsAcross all mediation analyses, our results suggested that social media use positively predicted adolescents' well-being. Given the multidimensional approach to both social media use and well-being, our findings suggested that adolescents' well-being was predicted not only by actual social media use behaviors but also by cognitions related to the expectation of receiving gratification on social media and the intense affective states related to the desire to use social media. Also, our data suggested that adolescents with high levels of depressive symptoms might be more likely to capitalize on social media use and have expectations related to receiving approval from others in the context of social media use.DiscussionDepressive symptoms might be more relevant when explaining the cognitive and affective involvement during social media use. However, their ability to predict the actual social media use behaviors may be limited. Furthermore, adolescents that present depressive symptoms might be more prone to use social media, in order to improve their well-being.
Formation mechanism and governance strategies of stigma in public health emergencies: Based on event system theory
Authors: Liu Shuzhen , Liu Yuanyuan , Guo Ming , Wang Rui , Sun Qiong , Zhu Rong 
Published: January 2023

IntroductionWith the new coronavirus (COVID-19) pandemic across the world, it is critical to propose effective strategies for stigma governance in public health emergencies in order to reduce negative effects caused by stigma. However, no known research has focused on the essential role of events in understanding stigma phenomenon from the perspective of external dynamic changes.MethodsBased on the event system theory, this paper analyzes the evolution mode and characteristics of specific events in the process of stigmatization from strength, space and time aspects, and taking COVID-19 event as an example, 1202 questionnaires and empirical analysis were conducted.Results and discussionOur results reveal that event strength directly affects the results of stigmatization, and such impact appears to be more prominent with a novel, disruptive and critical event. In addition, spatial and temporal attributes represent the dynamic development of an event, and they can interact with event strength to regulate the relationship between event strength and outcomes. Finally, stigma governance strategies under public health emergencies from three aspects of event strength, space, and time were put forward.
Evaluation of the implementation effect of hepatitis C medical insurance reimbursement policy in China: A RWS based on medical institutions
Authors: Liu Yiyao , Gou Liangwen , Guo Zhaoting , Wu Zhiang , He Qin , Feng Haihuan , Hu Ming 
Published: January 2023

ObjectivesTo evaluate the implementation effect of hepatitis C medical insurance reimbursement policy in China from the view of medical institutions.MethodsThe electronic medical record of a top tertiary hospital in Chengdu from January 2014 to December 2020 were extracted, and the interrupted time series model was used to analyze the changes in diagnosis and treatment behavior and disease burden of hepatitis C patients after the implementation of HCV insurance reimbursement policy.ResultsIn terms of diagnosis and treatment, the number of visits (β2 = 19.290, P &lt; 0.001) and treatments (β2 = 14.291, P &lt; 0.01) increased instantaneously after the implementation of the outpatient reimbursement policy in Chengdu in 2018, and there was no significant change after the implementation of the single line payment policy for oral direct antiviral (DAA) drugs in 2019 (P &gt; 0.05); in terms of medical expenses, the total treatment cost (β2 = 21439.3, P &lt; 0.001), out-of-pocket expenses (β2 = 6109.44, P &lt; 0.001) and drug expenses (β2 = 21889.8, P &lt; 0.001) of hepatitis C patients have been significantly reduced after the implementation of the single-line payment policy.ConclusionHepatitis C medical insurance reimbursement policy can promote hepatitis C patients to actively seek medical treatment, promote the widespread use of DAA scheme, reduce the burden of patients, and improve the treatment efficiency of hepatitis C.
Older adults' needs and requirements for a comprehensive exergame-based telerehabilitation system: A focus group study
Authors: Seinsche Julia , de Bruin Eling D. , Carpinella Ilaria , Ferrarin Maurizio , Moza Sotiria , Rizzo Francesco , Salatino Claudia , Giannouli Eleftheria 
Published: January 2023

IntroductionTelerehabilitation in older adults using information and communication technologies (ICTs) provides therapy, which is potentially equally effective as traditional rehabilitation, yet more accessible. This study aimed to analyze the needs and requirements of older adults (OA) and healthcare-professionals (HP) toward ICTs and telerehabilitation in general as well as toward a specific novel exergame-based telerehabilitation system (COCARE system, Dividat).Materials and methodsThe COCARE telerehabilitation system enables individual training based on exergames, as well as an assessment system and a digital centralized case management. Six focus groups with in total 34 participants were conducted. A mixed-methods approach was used comprising questionnaires and semi-structured interviews.ResultsBoth OA and HP would engage to an exergame-based telerehabilitation program. Major motivating factors are the relevance of such a training for health and the entertainment component of exergames. Main requirements are simplification of the system, variety, a personalized training, a constantly available contact person, and comprehensive instructions for use. Besides, HP praised the system's motivational effect, but remained concerned about risk of falls and social isolation.ConclusionICTs for telerehabilitation are accepted by OA and HP but should be adapted hardware- and software-wise to address OA' age-stemming vulnerabilities (e.g., risk of falls) and low ICT literacy.