bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lubricated Interfaces Enabling Simultaneous Pulsatile and Continuous Chemical Release Modes
Authors: Borbora Angana , Xu Yang , Dey Souradeep , Wang Xin , Yao Yuxing , Mandal Biman B. , Wang Xiaoguang , Manna Uttam 
Published: May 2023

AbstractThe release of chemicals following either pulsatile or continuous release modes is important for various potential applications, including programmed chemical reactions, mechanical actuation, and treatments of various diseases. However, the simultaneous application of both modes in a single material system has been challenging. Here, two chemical loading methods are reported in a liquid‐crystal‐infused porous surface (LCIPS) that enables both a pulsatile and continuous release of chemicals simultaneously. Specifically, chemicals loaded in the porous substrate exhibit a liquid crystal (LC) mesophase‐dependent continuous release, whereas the chemicals dissolved in micrometer‐sized aqueous droplets dispersed in the LC surface follow a pulsatile release activated by a phase transition. Moreover, the loading method of distinct molecules can be controlled to program their release mode. Finally, the pulsatile and continuous release of two distinct bioactive small molecules, tetracycline and dexamethasone, are demonstrated which display antibacterial and immunomodulatory activities for applications such as chronic wound healing and biomedical implant coating.
Advanced Phase Change Materials from Natural Perspectives: Structural Design and Functional Applications
Authors: Liu Lu , Zhang Yuang , Zhang Shufen , Tang Bingtao 
Published: May 2023

AbstractPhase change materials have garnered extensive interest in heat harvesting and utilization owing to their high energy storage density and isothermal phase transition. Nevertheless, inherent leakage problems and low heat storage efficiencies hinder their widespread utilization. Nature has served as a great source of inspiration for addressing these challenges. Natural strategies are proposed to achieve advanced thermal energy management systems, and breakthroughs are made in recent years. This review focuses on recent advances in the structural design and functions of phase change materials from a natural perspective. By highlighting the structure–function relationship, advanced applications including human motion, medicine, and intelligent thermal management devices are discussed in detail. Finally, the views on the remaining challenges and future prospects are also provided, that is, phase change materials are advancing around the biomimicry design spiral.
Carbon monoxide as a clinical marker of hemolysis
Authors: Osborne Jake , Sobh Mohamad , Trudel Guy 
Published: May 2023

AbstractCarbon monoxide (CO)‐based tests have precisely measured hemolysis for over 40 years. End‐tidal CO was the primary marker in clinical hematology research, followed by carboxyhemoglobin. Quantification of CO reflects heme oxygenases degrading heme in a 1:1 stoichiometric ratio, making CO a direct marker of hemolysis. CO in alveolar air can be quantified using gas chromatography, whose high resolution allows detecting mild and moderate levels of hemolysis. CO can be elevated in active bleeding, resorbing hematoma, and smoking. Clinical acumen and other markers remain necessary to diagnose the cause of hemolysis. CO‐based tests constitute an opportunity for bench‐to‐bedside technology transfer.
Documentation and prevalence of prenatal and neonatal outcomes in a cohort of individuals with KBG syndrome
Authors: Kierzkowska Ola , Sarino Kathleen , Carter Drake , Guo Lily , Marchi Elaine , Voronova Anastassia , Lyon Gholson J. 
Published: May 2023

AbstractAnkyrin Repeat Domain 11 (ANKRD11) gene mutations are associated with KBG syndrome, a developmental disability that affects multiple organ systems. The function of ANKRD11 in human growth and development is not clear, but gene knockout or mutation are lethal in mice embryos and/or pups. In addition, it plays a vital role in chromatin regulation and transcription. Individuals with KBG syndrome are often misdiagnosed or remain undiagnosed until later in life. This is largely due to KBG syndrome's varying and nonspecific phenotypes as well as a lack of accessible genetic testing and prenatal screening. This study documents perinatal outcomes for individuals with KBG syndrome. We obtained data from 42 individuals through videoconferences, medical records, and emails. 45.2% of our cohort was born by C‐section, 33.3% had a congenital heart defect, 23.8% were born prematurely, 23.8% were admitted to the NICU, 14.3% were small for gestational age, and 14.3% of the families had a history of miscarriage. These rates were higher in our cohort compared to the overall population, including non‐Hispanic and Hispanic populations. Other reports included feeding difficulties (21.4%), neonatal jaundice (14.3%), decreased fetal movement (7.1%), and pleural effusions in utero (4.7%). Comprehensive perinatal studies about KBG syndrome and updated documentation of its phenotypes are important in ensuring prompt diagnosis and can facilitate correct management.
Syntheses, characterizations, and Hirshfeld analysis of Ag(I) and Cu(II) complexes: A novel potent Ag(I)‐based oxadiazole anticancer agent
Authors: Ayoup Mohammed Salah , ElShafey Mariam M. , Abdel‐Hamid Hamida , Abu‐Serie Marwa M. , Teleb Mohamed , Dege Necmi , Soliman Saied M. 
Published: May 2023

The Ag(I) and Cu(II) complexes of the ligand, 2,2′‐(1,2,4‐oxadiazole‐3,5‐diyl) dianiline, (L; 4) were synthesized and characterized using different spectroscopic techniques. Their anticancer activities against three types of cancer cell lines were explored. The [AgL (NO3)]n complex (5) has 1D polymeric structure whereas the [CuL (NO3)2] (6) and [CuLCl2] (7) are monomeric complexes. The Ag(I) in 5 is tetra‐coordinated and has AgN2O2 coordination sphere where both L and NO3¯ are bridging the Ag(I) sites along the polymer array. In 6 and 7, the coordination environments are CuN3O3 and CuN3Cl2, respectively. In both cases, the oxadiazole ligand is a tridentate chelate via two N‐atoms from both amino groups and one N‐atom from the oxadiazole moiety. Hirshfeld analysis revealed the importance of O … H (23.5%), H … H (24.8%), and C … C (6.6%) non‐covalent interactions in the molecular packing of 5. In 6, the O … H (40.7%), N … H (4.9%), O … O (5.9%), N … O (3.2%), and C … N (2.2%) contacts are the most important. Regarding safety on normal human fibroblasts Wi‐38, MTT assay for all metal complexes especially the Ag(I) complex 5 exhibited higher safety profiles than the free oxadiazole ligand as well as the standard chemotherapeutic drug 5‐fluroruracil (5‐FU). The cytotoxic activities of complexes 5–7 surpassed 5‐FU against A549, Caco‐2, and MDA‐MB231 cell lines. 5 has the best anticancer activity (IC50 = 0.074, 0.085, and 0.533 μM, respectively) and exhibiting pronounced selectivity index up to 44.3. Quantitative PCR analysis of BAX and BCL‐2 revealed their apoptotic induction mechanism and showed that the metal complexes can repress the main oncogene BCL‐2 and enhance the expression of proapoptotic gene BAX. Again, 5 is the most potent with 14.28 folds BCL‐2 downregulation and 4.86 folds BAX upregulation.
Thermal degradation kinetics of high‐performance urea‐formaldehyde resin prepared by replacing partial urea with soybean processing residue
Authors: He Di , Guo Yuhan , Zhao Fenghang , Wang Chen , Zheng Wenyu , Hou Tianle , Xie Xin , Chen Yuzhu , Xiao Hui 
Published: May 2023

AbstractIn this work, soybean meal was applied to replace partial urea to prepare high‐performance urea‐formaldehyde resin (SMUF). The optimum addition amount of soybean meal was screened by the basic properties of resin, the bonding strength and formaldehyde emission of the board. The activation energy (Ea) and reaction kinetics at different conversion rates were estimated by Kissinger and Flynn–Wall–Ozawa methods. The results showed that when 5 wt% soybean meal was used to replace urea, the formaldehyde emission of plywood decreased by 19.23% and the bonding strength increased by 36.29%, which were 0.84 mg L−1 and 1.69 MPa, respectively. Meanwhile, the thermal stability of Urea‐formaldehyde (UF) resin is improved. The thermal degradation Ea of SMUF is higher than that of UF, the reaction kinetic equation of both UF and SMUF are G(α) = [−ln (1 − α)]2. It is feasible to replace partial urea with soybean meal. When the addition level of soybean meal is 5 wt%, SMUF has better comprehensive performance. When the addition level of soybean meal is 10–20 wt%, the bonding strength of plywood is higher than that of UF, but the formaldehyde emission is higher. How to reduce the formaldehyde emission will be the direction of future research.
Fabrication of electrospun nanofibrous clinoptilolite doped thermoplastic polyurethane scaffolds for skeletal muscle tissue engineering
Authors: Yıldırım Meryem Akkurt , Sanli Abdulkadir , Türkoğlu Nelisa , Denktaş Cenk 
Published: May 2023

AbstractThe treatment of skeletal muscle, which lost its function with damage or trauma with autologous muscle tissue transfer, is a very problematic approach. Hence, it is critical to develop materials that are mimicking muscle tissue mechanical behaviors and allowing cell adhesion. Polyurethanes (PUs) are one of the most common polymers in tissue engineering applications and skeletal muscle regeneration due to their elasticity and mechanical flexibility. Clinoptilolite (CLN) is a hydrated alumina silica crystal based biocompatible material that numerous positive effects on animal and human health. Here, we report the synthesize of flexible membranes based on clinoptilolite (CLN) doped thermoplastıc polyurethane (TPU) nanofiber network to be used in the field of skeletal muscle regeneration. We primarily evaluated their ability to mimic skeletal muscle by determining their mechanical properties and cell adhesion rates. We observe that cell adhesion and proliferation increased with the increase of CLN contribution. Young modulus (EY) values of pure TPU, 5 and 10 wt.% CLN‐doped TPU fibers are 3.66, 2.37, and 1.85 MPa, respectively. Mechanical elongations at break of pure TPU, 5 and 10 wt.% CLN‐doped TPU fibers after 37°C treatment (7th day) are 193.41%, 113.30%, and 197.15%, respectively. With the addition of 5 wt.% CLN, the thermal stability slightly increased compared to the pure TPU and 10 wt.% CLN/TPU. In addition, cytotoxicity studies reveal that CLN/PU membranes are biocompatible, and finally cell adhesion increases proportionally to the increased CLN contribution. The obtained results indicate that the CLN/PU membranes can be used as a skeletal muscle scaffold.
Capturing the Dynamics of Ti Diffusion Across TixW1−x/Cu Heterostructures using X‐Ray Photoelectron Spectroscopy
Authors: Kalha Curran , Thakur Pardeep K. , Lee Tien‐Lin , Reisinger Michael , Zechner Johannes , Nelhiebel Michael , Regoutz Anna 
Published: May 2023

AbstractInterdiffusion phenomena between adjacent materials are highly prevalent in semiconductor device architectures and can present a major reliability challenge for the industry. To fully capture these phenomena, experimental approaches must go beyond static and post‐mortem studies to include in situ and in‐operando setups. Here, soft and hard X‐ray photoelectron spectroscopy (SXPS and HAXPES) is used to monitor diffusion in real‐time across a proxy device. The device consists of a Si/SiO2/TixW1−x(300 nm)/Cu(25 nm) thin film material stack, with the TixW1−xfilm (x = 0.054, 0.115, 0.148) acting as a diffusion barrier between Si and Cu. The interdiffusion is monitored through the continuous collection of spectra whilst in situ annealing to 673 K. Ti within the TiW is found to be highly mobile during annealing, diffusing out of the barrier and accumulating at the Cu surface. Increasing the Ti concentration within the TixW1−xfilm increases the quantity of accumulated Ti, and Ti is first detected at the Cu surface at temperatures as low as 550 K. Surprisingly, at low Ti concentrations (x = 0.054), W is also mobile and diffuses alongside Ti. By monitoring the Ti 1score level with HAXPES, the surface‐accumulated Ti was observed to undergo oxidation even under ultra‐high vacuum conditions, highlighting the reactivity of Ti in this system. These results provide crucial evidence for the importance of diffusion barrier composition on their efficacy during device application, delivering insights into the mechanisms underlying their effectiveness and limitations.
Nano‐Cracks and Glass Carving from Non‐Symmetrically Converging Shocks
Authors: Gutiérrez‐Hernández Ulisses J. , Reese Hendrik , Reuter Fabian , Ohl Claus‐Dieter , Quinto‐Su Pedro A. 
Published: May 2023

AbstractA method is presented to carve into a glass submerged in water with laser‐induced surface and shock waves. It starts with an elliptic wave source that launches an elliptically converging Rayleigh and shock wave. At the wave focus a single microscopic crack with controlled location and orientation is induced that has a length of a few micrometers and a width of about 100 nm. Through successive surface waves, this crack may be extended along a specific direction which can be controlled by adjusting the distance, shape, and orientation of the laser focus. Here, either point‐like or elliptical laser foci are generated using a spatial light modulator. Furthermore, when the crack is guided along a closed circular path using a point like laser focus, a conchoidal hole may be carved through the glass slide demonstrated with a 160 µm thick cover slip. The shock waves are modeled in the fluid and the elastic waves in the glass in three dimensions with a finite‐volume framework that accounts for fluid‐structure interaction. The resulting pressures and stresses for both the elliptical and point‐like Rayleigh and shock wave sources are reported.
Solvent‐free Ternary Polymer Electrolytes with High Ionic Conductivity for Stable Sodium‐based Batteries at Room Temperature
Authors: Roscher Daniel , Kim Yongil , Stepien Dominik , Zarrabeitia Maider , Passerini Stefano 
Published: May 2023

AbstractTransitioning to solid‐state batteries using polymer electrolytes results in inherently safer devices and can facilitate the use of sodium metal anodes enabling higher energy densities. In this work, solvent‐free ternary polymer electrolytes based on cross‐linked polyethylene oxide (PEO), sodium bis(fluorosulfonyl) imide (NaFSI) or sodium bis(trifluoromethanesulfonyl) imide (NaTFSI) and N‐butyl‐N‐methyl‐pyrrolidinium‐based ionic liquids (ILs, Pyr14FSI or Pyr14TFSI) are developed. Synthesized polymer membranes are thoroughly characterized, verifying their good thermal and electrochemical stability, as well as a low glass transition and crystallinity, thus high segmental mobility of the polymer matrix. The latter results in good ionic conductivities around 1×10−3 S cm−1 at 20 °C. The polymer electrolytes are successfully employed in sodium‐metal battery (SMB) cells operating at room temperature (RT) and using P2‐Na2/3Ni1/3Mn2/3O2 layered oxide as cathode. The electrochemical performance strongly depends on the choice of anion in the conducting sodium salt and plasticizing IL. Furthermore, this solid‐state SMB approach mitigates capacity fading drivers for the P2‐Na2/3Ni1/3Mn2/3O2, resulting in high Coulombic efficiency (99.91 %) and high capacity retention (99 % after 100 cycles) with good specific capacity (140 mAh g−1).
An evaluation of Headsprout early reading as an online parent‐mediated intervention for primary school children
Authors: Gillespie Emma , Markham Victoria , Tiernan Aoife Mc 
Published: May 2023

AbstractDue to the Coronavirus pandemic and lengthy absences from the classroom, there is a need for large‐scale remedial programs to support young children to “catch‐up” on literacy and numeracy skills. A stratified randomized controlled trial was used to evaluate the Headsprout Early Reading (HER) program as a parent‐mediated digital literacy intervention. A between‐groups design compared differences in reading‐dependent outcome measures for 36 children assigned to one of three intervention groups: with support, without support, and waitlist‐control. Children completed significantly more episodes when parents received implementation support from the researcher compared to the without support group. Children receiving Headsprout instructions demonstrated marginally greater gains than the waitlist‐control group in posttest outcome measures; however, differences in reading outcomes were not significant between groups at posttesting. The current research provides tentative support for HER and importantly, highlights the importance of providing support for parents implementing interventions at home.
Reconstructing the cell–cell interaction network among mouse immune cells
Authors: Azadian Somayeh , Doustmohammadi Alireza , Naseri Mohadeseh , Khodarahmi Masoud , Arab Seyed Shahriar , Yazdanifar Mahboubeh , Zahiri Javad , Lewis Nathan E. 
Published: May 2023

AbstractIntercellular interactions and cell–cell communication are critical to regulating cell functions, especially in normal immune cells and immunotherapies. Ligand–receptor pairs mediating these cell–cell interactions can be identified using diverse experimental and computational approaches. Here, we reconstructed the intercellular interaction network between Mus musculus immune cells using publicly available receptor–ligand interaction databases and gene expression data from the immunological genome project. This reconstructed network accounts for 50,317 unique interactions between 16 cell types between 731 receptor–ligand pairs. Analysis of this network shows that cells of hematopoietic lineages use fewer communication pathways for interacting with each other, while nonhematopoietic stromal cells use the most network communications. We further observe that the WNT, BMP, and LAMININ pathways are the most significant contributors to the overall number of cell–cell interactions among the various pathways in the reconstructed communication network. This resource will enable the systematic analysis of normal and pathologic immune cell interactions, along with the study of emerging immunotherapies.
An alternative method for esthetic and functional management of oral pyogenic granuloma
Authors: Güler Kübra , Görgün Emine Pirim 
Published: May 2023

AbstractBackgroundPyogenic granulomas (PGs) are gingival enlargements which cause esthetic and functional problems that hinder chewing and maintaining oral hygiene. In this series consisting of six cases, we report the rehabilitation of PG using partly de‐epithelialized gingival grafts.MethodsFollowing documentation of clinical measurements, a concurrent treatment plan of excision and reconstruction with partly de‐epithelialized gingival grafts were followed for all the cases. Six months following procedures, clinical parameters were measured again and a short patient‐reported outcome measures consisting of three questions were applied.ResultsIn histological evaluations, PG features were observed. In the fourth postoperative week, interdental papilla and attached gingiva were restored. Six months follow‐up showed reduction in plaque and gingival indices, clinical attachment loss, and mobility. Mean keratinized tissue height was increased from 2.58 ± 2.20 to 6.66 ± 1.66 in the 6th month of operation. Oldest case was stable after 12 months of follow‐up and no infection was found at grafting sites. Papillary coverage was achieved.ConclusionIf the PG is not completely removed due to esthetic reservations, a recurrence may occur. Within our limitations, we can suggest that the immediate esthetic rehabilitation with partly de‐epithelialized gingival graft presents a compatible approach in the treatment of mucogingival defects after aggressive excision of PG.
The regulation of child pornography in China and the United States: A comparative review of laws
Authors: Zhou Shuhuan 
Published: May 2023

AbstractGrounded in comparative law research, this paper compares differences in the regulation of online child pornography in China and the United States. The United States began regulating child pornography through criminal law in the 1970s, gradually refining the laws to distinguish between child pornography and obscenity and prohibit the possession of child pornography and virtual child pornography. In contrast, China treats child pornography on an equal footing with adult pornography, but imposes more lenient penalties on disseminating child pornography, which has led to the proliferation of child pornography. By comparing the two countries' policies and laws on child pornography, this review makes four recommendations for other countries: (i) define child pornography in criminal law; (ii) distinguish between obscenity and child pornography; (iii) prohibit virtual child pornography on the internet; and (iv) increase criminal penalties for child pornography.
Comparison of different density functional theory methods for the calculation of vibrational circular dichroism spectra
Authors: Groß Jonathan , Kühlborn Jonas , Pusch Stefan , Weber Carina , Andernach Lars , Renzer Galit , Eckhardt Paul , Brauer Jan , Opatz Till 
Published: May 2023

AbstractThe determination of the absolute configuration (AC) of an organic molecule is still a challenging task for which the combination of spectroscopic with quantum‐mechanical methods has become a promising approach. In this study, we investigated the accuracy of DFT methods (480 overall combinations of 15 functionals, 16 basis sets, and 2 solvation models) to calculate the VCD spectra of six chiral organic molecules in order to benchmark their capability to facilitate the determination of the AC.
Density Functional Theory‐Based Protocol to Calculate the Redox Potentials of First‐row Transition Metal Complexes for Aqueous Redox Targeting Flow Batteries
Authors: Rahbani Noura , de Silva Piotr , Baudrin Emmanuel 
Published: May 2023

AbstractTransition metal complexes are a promising class of redox mediators for targeting redox flow batteries due to the tunability of their electrochemical potentials. However, reliable time‐efficient tools for the prediction of their reduction potentials are needed. In this work, we establish a suitable density functional theory protocol for their prediction using an initial experimental data set of aqueous iron complexes with bidentate ligands. The approach is then cross‐validated using different complexes found in the redox‐flow literature. We find that the solvation model affects the prediction accuracy more than the functional or basis set. The smallest errors are obtained using the COSMO‐RS solvation model (mean average error (MAE)=0.24 V). With implicit solvation models, a general deviation from experimental results is observed. For a set of similar ligands, they can be corrected using simple linear regression (MAE=0.051 V for the initial set of iron complexes).