bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on surface Morphology of 7075 aluminum alloy deep hole by two-dimensional ultrasonic elliptical vibration Boring
Authors: Ye Yanqiu , Tong Jinglin , Hu Guiling , Liu Ziqiang , Yang Shuaikun 
Published: July 2023

Abstract
The study focused on the use of two-dimensional ultrasonic elliptical vibration boring (2D-UEVB) to improve the surface quality of deep hole tube parts made from 7075 aluminum alloy. The tool tip trajectory model and the surface roughness model of 2D-UEVB deep hole were established. It was found that 2D-UEVB could obtain lower surface roughness than common boring (CB) through analyzing the theoretical model. Finally, the effects of boring parameters and acoustic parameters on surface morphology were studied throughsingle factor test and four-factor four-level orthogonal test. After the 2D-UEVB, the surface roughness Ra value decreased in different degreesaccording to the experimental results. However, the reduction of Ra was affected differently by the various acoustic parameters and boring parameters. With the increase of feed rate, the surface roughness Ra shows a significant increasing trend. With the increase of spindle speed, the surface roughness Ra shows a trend of decreasing first and then increasing. The Ra displayed a continuous decreasing trend with the ultrasonic amplitude increased. The influence of cutting depth on the roughness is not significant. The results demonstrated that better surface texture and surface quality can be obtained with lower feed rate, medium spindle speed and larger ultrasonic amplitude in two-dimensional ultrasonic vibration boring.
Universal sublinear resistivity in vanadium kagome materials hosting charge density waves
Authors: Mozaffari Shirin , Mandrus David , Meier William , Madhogaria Richa Pokharel , Peshcherenko Nikolai , KANG SEOUNGHUN , Villanova John , Arachchige Hasitha Suriya , Zheng Guoxin , Zhu Yuan , Chen Kuan-Wen , Jenkins Kaila , Zhang Dechen , Chan Aaron , Li Lu , Yoon Mina , Zhang Yang 
Published: July 2023

Abstract
The recent discovery of a charge density (CDW) state in ScV6Sn6 at TCDW = 91 K offers new opportunities to understand the origins of electronic instabilities in topological kagome systems. By comparing to the isostructural non-CDW compound LuV6Sn6, we unravel interesting electrical transport properties in ScV6Sn6, above and below the charge ordering temperature. We observed that by applying a magnetic field along the a axis, the temperature behavior of the longitudinal resistivity in ScV6Sn6 changes from metal-like to insulator-like above the CDW transition. We show that in the charge ordered state ScV6Sn6 follows the Fermi liquid behavior while above that, it transforms into a non-Fermi liquid phase in which the resistivity varies sublinearly over a broad temperature range. The sublinear resistivity, which scales by T3/5 is a common feature among other vanadium-containing kagome compounds exhibiting CDW states such as KV3Sb5, RbV3Sb5, and CsV3Sb5. By contrast, the non-Fermi liquid behavior does not occur in LuV6Sn6. We explain the T3/5 universal scaling behavior from the Coulomb scattering between Dirac electrons and Van Hove singularities; common features in the electronic structure of kagome materials. Finally, we show anomalous Hall-like behavior in ScV6Sn6 below TCDW, which is absent in the Lu compound. Comparing the transport properties of ScV6Sn6 and LuV6Sn6 is valuable to highlight the impacts of the unusual CDW in the Sc compound.
Efficacy and safety of postoperative preemptive use of tolvaptan for patients with liver injury undergoing hepatectomy for hepatocellular carcinoma
Authors: Kobayashi Yuta , Shindoh Junichi , Kojima Kazutaka , Akabane Miho , Kobayashi Masahiro , Okubo Satoshi , Matsumura Masaru , Hashimoto Masaji 
Published: July 2023

Abstract
Purpose
Optimal choice of diuretics in perioperative management remains unclear in enhanced recovery after liver surgery. This study investigated the efficacy and safety of tolvaptan (oral vasopressin V2-receptor antagonist) in postoperative management of patients with liver injury and hepatocellular carcinoma.
Methods
The patients clinically diagnosed with liver cirrhosis were included in this study. Clinical outcomes of 51 prospective cohort managed with a modified postoperative protocol using tolvaptan (validation group) were compared with 83 patients treated with a conventional management protocol (control group).
Results
Postoperative urine output were significantly larger and excessive body weight increase were reduced with no impairment in renal function or serum sodium levels in the validation group. Although the total amount of discharge and trend of serum albumin level were not significantly different among the groups, global incidence of postoperative morbidity was less frequent (19.6% vs. 44.6%, P = 0.005) and postoperative stay was significantly shorter (8 days vs.10 days, P = 0.008) in the validation group compared with the control group.
Conclusions
Tolvaptan could be safely used for the patients with injured liver in postoperative management after hepatectomy and potentially advantageous in the era of enhanced recovery after surgery with its strong diuretic effect and better fluid management.
Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19
Authors: Sugiura Yuki , Maeda Rae , Seki Natsumi , Uwamino Yoshifumi , Wakui Masatoshi , Nakagama Yu , Kido Yasutoshi , Sasai Miwa , Yamamoto Masahiro , Matsuura Yoshiharu , Uchiyama Jun , Yamaguchi Genki , Hirakawa Makoto , Kim Yun-Gi , Mishima Masayo , Suematsu Makoto 
Published: July 2023

Abstract
Effective early-stage markers for predicting which patients are at risk of developing SARS-CoV-2 infection have not been fully investigated. Here, through comprehensive serum metabolome analysis, we identified that the acceleration of amino acid catabolism within 5 d from disease onset correlated with future disease severity. Increased levels of de-aminated amino acids catabolites involved in the de novo nucleotide synthesis pathway were identified as early prognostic markers that correlated with the initial viral load. We demonstrated in mice models of SARS-CoV2-MA10 and influenza infection that such de-amination of amino acids and de novo synthesis of nucleotides were associated with the abnormal proliferation of airway and vascular tissue cells in the lungs during the early stages of infection. Consequently, lung parenchymal tissue remodeling in the early stages of respiratory viral infections induces systemic metabolic remodeling, and the amino acid catabolites are valid predictors for excessive inflammatory response at later disease stages.
Anterior fusion surgery with overcorrection in the treatment of adolescent idiopathic scoliosis with Lenke 1 AR curve type: How to achieve overcorrection and its effect on postoperative spinal alignment
Authors: Tanaka Nobuki , Inami Satoshi , Moridaira Hiroshi , Sorimachi Tsuyoshi , Ueda Haruki , Aoki Hiromichi , Takada Satoshi , Nohara Yutaka , Haro Hirotaka , Taneichi Hiroshi 
Published: July 2023

Abstract
Background
The efficacy of anterior fusion with overcorrection in the instrumented vertebra for Lenke 1 AR type curves has been reported, but how to achieve overcorrection and how overcorrection affects spinal alignment are unclear. The purpose of this study was to identify the factors that cause overcorrection, and to investigate how overcorrection affects postoperative spinal alignment in the surgical treatment of Lenke 1 AR type curves.
Methods
Patients who had anterior surgery for a Lenke type 1 or 2 and lumbar modifier AR (L4 vertebral tilt to the right) type scoliosis and minimum 2-year follow-up were included. The radiographic data were measured at preoperative, postoperative 1 month, and final follow-up. The UIV-LIV Cobb angle was determined as the Cobb angle between the upper instrumented vertebra (UIV) and the lower instrumented vertebra (LIV), and a negative number for this angle was considered overcorrection. The screw angle was determined to be the sum of the angle formed by the screw axis and the lower and upper endplates in the LIV and UIV, respectively. The change (Δ) in the parameters from postoperative to final follow-up was calculated. The relationships between the UIV-LIV Cobb angle and other radiographic parameters were evaluated by linear regression analyses.
Results
Fourteen patients met the inclusion criteria. Their median age was 15.5 years, and the median follow-up period was 53.6 months. The median UIV-LIV Cobb angle was − 1.4° at postoperative 1 month. The median screw angle was 4.7°, and overcorrection was achieved in 11 (79%) cases at postoperative 1 month. The screw angle (r2 = 0.42, p = 0.012) and Δ below LIV-CSVL (the deviation of the first vertebra below the LIV from the central sacral vertical line, r2 = 0.53, p = 0.003) were significantly correlated with the UIV-LIV Cobb angle.
Conclusions
Screw placement in the UIV and LIV not parallel to the endplate, but angled, was an effective method to facilitate overcorrection in the instrumented vertebrae. The results of the present study suggest that overcorrection could bring spontaneous improvement of coronal balance below the instrumented segment during the postoperative period.
Combined effects of nitrate and medium-chain fatty acids on methane production, rumen fermentation, and rumen bacterial populations in vitro
Authors: Vadroňová Mariana , Šťovíček Adam , Jochová Kateřina , Výborná Alena , Tyrolová Yvona , Tichá Denisa , Homolka Petr , Joch Miroslav 
Published: July 2023

Abstract

This study investigated the combined effects of nitrate (NT) and medium-chain fatty acids (MCFA), including C8, C10, C12, and C14, on methane (CH4) production, rumen fermentation characteristics, and rumen bacteria using a 24 h batch incubation technique. Four types of treatments were used: control (no nitrate, no MCFA), NT (nitrate at 3.65 mM), NT+MCFA (nitrate at 3.65 mM + one of the four MCFA at 500 mg/L), and NT+MCFA/MCFA (nitrate at 3.65 mM + a binary combination of MCFA at 250 and 250 mg/L). All treatments decreased (P < 0.001) methanogenesis (mL/g apparent dry matter disappearance) compared with the control, but their efficiency was dependent on the MCFA type. The most efficient CH4 inhibitor was the NT+C10 treatment (–40%). The combinations containing C10 and C12 had the greatest effect on bacterial alpha diversity and relative microbial abundance (P < 0.001). Next-generation sequencing showed that the family Succinivibrionaceae was favored in treatments with the greatest CH4 inhibition at the expense of Prevotella and Ruminococcaceae. Furthermore, the relative abundance of Archaea decreased (P < 0.05) in the NT+C10 and NT+C10/C12 treatments. These results confirm that the combination of NT with MCFA (C10 and C12 in particular) may effectively reduce CH4 production.
Theoretical study on the glycosidic C-C bond cleavage of 3”-oxo-puerarin
Authors: Choi Jongkeun , Kim Yongho , Eser Bekir , Han Jaehong 
Published: July 2023

Abstract
Puerarin, daidzein C-glucoside, was known to be biotransformed to daidzein by human intestinal bacteria, which is eventually converted to (S)-equol. The metabolic pathway of puerarin to daidzein by DgpABC of Dorea sp. PUE strain was reported as puerarin (1) → 3”-oxo-puerarin (2) → daidzein (3) + hexose enediolone (C). The second reaction is the cleavage of the glycosidic C-C bond, supposedly through the quinoid intermediate (4). In this work, the glycosidic C-C bond cleavage reaction of 3”-oxo-puerarin (2) was theoretically studied by means of DFT calculation to elucidate chemical reaction mechanism, along with biochemical energetics of puerarin metabolism. It was found that bioenergetics of puerarin metabolism is slightly endergonic by 4.99 kcal/mol, mainly due to the reaction step of hexose enediolone (C) to 3”-oxo-glucose (A). The result implied that there could be additional biochemical reactions for the metabolism of hexose enediolone (C) to overcome the thermodynamic energy barrier of 4.59 kcal/mol. The computational study focused on the C-C bond cleavage of 3”-oxo-puerarin (2) found that formation of the quinoid intermediate (4) was not accessible thermodynamically, rather the reaction was initiated by the deprotonation of 2”C-H proton of 3”-oxo-puerarin (2). The 2”C-dehydro-3”-oxo-puerarin (2a2C) anionic species produced hexose enediolone (C) and 8-dehydro-daidzein anion (3a8), and the latter quickly converted to daidzein through the daidzein anion (3a7). Our study also explains why the reverse reaction of C-glycoside formation from daidzein (3) and hexose enediolone (C) is not feasible.
Multi-channel Small Animal Drug Metabolism Real-time Monitoring Fluorescence System
Authors: Qian Zhiyu 
Published: July 2023

Abstract

Purpose The data acquisition of drug metabolism analysis requires a lot of time and animal resources. However, there are often many deviations in the results of pharmacokinetic analysis. Conventional methods cannot measure the blood drug concentration data in multiple tissues at the same time, and the data is obtained by in vitro measurement, which produces time errors, in vitro data errors, and individual differences between animals. In the analysis of pharmacokinetic parameters, it will seriously affect the pass rate of clinical trials of R&D drugs and the accuracy of the dosing schedule. To the best of our knowledge, we have not found the study of in vivo blood drug concentration using multi-channel equipment. Therefore, the purpose of this paper is to build a set of multi organ monitoring and analysis instruments for synchronously monitoring the metabolism of drugs in various tissues of small animals, so as to obtain real in vivo data of blood drug concentration in real time.
Procedures Using the fluorescence properties and Laser-induced fluorescence principle of drugs, we designed six channels to monitor the changes of fluorescence-labeled drugs in their main metabolic organs, a multi-channel calibration method was proposed to improve the accuracy of the Time-division multiplexing, the real-time collection of drug concentration in vivo is realized and the drug metabolism curve in vivo can be observed.
Results The instrument satisfies the collection of small doses of drugs such as ug, the detection sensitivity can reach 10 ng/ml, and can monitor and collect the drug metabolism of multiple small animal tissues at the same time, which greatly reduces the use of animals, reduces the differences between individuals, and reduces consumption cost and improve the detection efficiency of parameters, and obtain data information that is closer to the real biology.
Conclusion Realized the real-time continuous monitoring and data collection of the drug metabolism in the plasma of living small animals and the important organs such as kidney, liver and spleen. The research and development of new drugs and clinical research have higher practical value.
Estimation of Regional-Scale Near Real Time Reference Evapotranspiration Using Remote Sensing and Weather Data to Improve Agriculture Advisory
Authors: Soni Anil Kumar , Tripathi Jayant Nath , Ghosh Kripan , Singh Priyanka , Sateesh M. , Singh K. K. 
Published: July 2023

Abstract

Accurate and timely information of evapotranspiration (ET0) is essential for multiple agricultural applications, including irrigation scheduling, studying crop-specific water loss at different growth stages, predicting crop yields, and forecasting drought conditions. The aim of this study is to examine the spatiotemporal patterns of ET0 and facilitate the monitoring of crop water demand, optimizing irrigation water usage, and enhancing agricultural advisory services. This paper estimates regional-level daily ET0 gridded data with a spatial resolution of 12.5 km by integrating observed weather data, IMD GFS-T1534 reanalysis data, and INSAT-3D satellite-based insolation product using the standard FAO56 Penman-Monteith empirical equation. The estimated monthly mean of ET0 across India ranged from 10 to 400 mm. ET0 exhibited an increasing trend from January to May, reaching its maximum values in May. In June, ET0 significantly decreased as the monsoon arrived, coinciding with the movement of rainfall patterns. The month of December exhibited the lowest ET0 values. The estimated daily gridded ET0 was compared with station-based ET0, resulting in daily correlation coefficient R2 and daily maximum absolute percentage errors ranging from 0.34 to 0.90 and 10% to 27% respectively. However, these errors decreased to a large extent when considering multiday accumulated values. A comparison was conducted between the GLDAS model ET0 and the station-estimated values, revealing an overestimation of ET0 by the GLDAS model. Additionally, significant variations were observed among the meteorological subdivisions. This highlights the necessity for proper calibration of the GLDAS model ET0 or its effective agricultural application.
Design and Analysis of Financial Supervision Detection and Collaborative Decision System Based on Artificial Intelligence
Authors: Zhao Ting , Liu Ran 
Published: July 2023

Abstract
With the complexity and increasing risks of financial markets, financial regulation has become more urgent and important. This article designs and analyzes a financial regulatory detection and collaborative decision-making system based on artificial intelligence to address this issue. The system aims to effectively measure systemic financial risks and provide early warning to protect investors' interests, guide enterprise decision-making, and strengthen financial supervision. Through the nonlinear Glenmorangie distillery causality test and correlation analysis, the indicators that have a significant impact on the systemic financial risk are screened out, which further verifies the characteristics of the financial Systemic risk that has a wide range of sources and is complex and diverse. In the construction of a systematic financial risk warning model, the Twin SVM model was adopted, and the optimal parameter settings of the model were determined through experimental comparison of different kernel functions and hysteresis periods. The Twin SVM model exhibits excellent predictive power, stability, and generalization performance, which can accurately predict pressure information in the financial market. The artificial intelligence based financial regulatory detection and collaborative decision-making system designed in this article can effectively measure systemic financial risks, provide early warning, and provide important reference and decision-making basis for investors, enterprise managers, and financial regulators.
Early cellular activity of GelMA as a Photopolymerized Hydrogel using an ex vivo tooth slice model
Authors: Marie Bryan St. , Kucuk Meltem , Aksel Hacer 
Published: July 2023

Abstract

Objectives
This study determined the cellular effect of a light-polymerized three-dimensional hydrogel, Gelatin methacryloyl (GelMA), on dental pulp stem cells (DPSCs) and human umbilical vein endothelial cells (HUVEC) using an in vitro dentin slice model.
Materials and Methods
DPSCs were cultured on dentin discs which were filled with GelMA or Biodentine. Cells cultured without dentin or on untreated dentin discs were used as controls. DPSC viability, migration, alkaline phosphatase (ALP) activity, and angiogenic tubule formation and von-Willebrand factor (vWF) release by HUVECs were determined. One-way ANOVA or Kruskal-Wallis tests was used to analyze the data.
Results
DPSCs showed similar viability in the GelMA, Biodentine, and untreated dentin disc groups at 4 days (p > 0.05), while higher cell viability was observed on GelMA than Biodentine at 7 days (p < 0.05). The migration and ALP activity were superior in the untreated dentin and GelMA groups compared to Biodentine (p < 0.05). HUVECs showed similar vWF release and tubule density on the GelMA and untreated dentin groups (p > 0.05). Biodentine significantly decreased vWF release (p < 0.05) and did not show any angiogenic tubule formation by HUVECs.
Conclusion
GelMA filled dentin discs enhanced viability, migration, mineralization and angiogenic ability of the cells compared to Biodentine.
Clinical Relevance
GelMA as a photopolymerized hydrogel enhanced cell viability and differentiation that can allow pulpal healing at the damaged site under the sealing materials.
Nomograms Constructed for Predicting Diagnosis and Prognosis in Cervical Cancer Patients with Second Primary Malignancies: A SEER Database Analysis
Authors: Xie Ning , Lin Jie , Liu Linying , Deng Sufang , Yu Haijuan , Sun Yang 
Published: July 2023

Abstract
Purpose
Cervical cancer (CC) patients are more likely to develop second primary malignancies (SPMs) than general population. With the advancement in cancer therapy, CC patients are achieving long-term survival, leading SPMs to our attention. Our study aims to establish diagnostic and prognostic nomograms for CC patients with second primary malignancies (CCSPMs) to help make personalized follow-up plans and treatments.
Methods
Data of CCSPMs between 2000 and 2019 was extracted from SEER. The proportions and the average interval time of CCSPM onset were calculated. 11 related clinical characteristics, including age, race, marital status, grade, FIGO stage, radiotherapy, chemotherapy, and surgery, were further explore. Logistic and Cox regressions were employed to predict risk factors for CCSPMs diagnosis. Finally, two nomograms were developed to predict the probability occurrence and prognosis of CCSPMs, respectively.
Results
For diagnostic nomogram construction, 59,178 CC patients were randomly divided into training (n = 41,426) and validation cohorts (n = 17,752). For prognostic nomogram construction, 3,527 CCSPMs patients were randomly divided into training (n = 2,469) and validation cohorts (n = 1,058). The diagnostic nomogram consisting of above eleven independent risk factors (all P < 0.05), had high accuracy (AUCtraining = 0.851 and AUCvalidating = 0.845). The prognostic nomogram integrated with eight independent prognostic factors such as treatments, FIGO stage and TNM stage, performed well in predicting 5-year OS (AUCtraining = 0.835 and AUCvalidating = 0.837).
Conclusion
Our diagnostic and prognostic nomograms could facilitate clinicians to quantify individual SPMs risk and survival probabilities and optimize the surveillance recommendations and personalized clinical decision-making.