bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi objective factory layout planning using simulation-based reinforcement learning
Authors: Klar Matthias , Schworm Philipp , Wu Xiangqian , Glatt Moritz , Ravani Bahram , Aurich Jan C. 
Published: April 2023

Abstract

Factory layout planning aims at finding an optimized layout configuration under consideration of varying influences such as the material flow characteristics. Manual layout planning can be characterized as a complex decision-making process due to a large number of possible placement options. Automated planning approaches aim at reducing the manual planning effort by generating optimized layout variants in the early stages of layout planning. Recent developments have introduced Reinforcement Learning (RL) based planning approaches that allow to optimize a layout under consideration of a single optimization criterion. However, within layout planning, multiple partially conflicting planning objectives have to be considered. Such multiple objectives are not considered by existing RL-based approaches. This paper addresses this research gap by presenting a novel RL-based layout planning approach that allows consideration of multiple objectives for optimization. Furthermore, existing RL-based planning approaches only consider analytically formulated objectives such as the transportation distance. Consequently, dynamic influences in the material flow are neglected which can result in higher operational costs of the future factory. To address this issue, a discrete event simulation module is developed that allows simulating manufacturing and material flow processes simultaneously for any layout configuration generated by the RL approach. Consequently, the presented approach considers material flow simulation results for multi-objective optimization. In order to investigate the capabilities of RL-based factory layout planning, different RL architectures are compared based on a simplified application scenario. In terms of optimization objectives, the throughput time, media supply, and clarity of the material flow are considered. The best performing architecture is then applied to an industrial planning scenario with 43 functional units to illustrate the approach. Furthermore, the performance of the RL approach is compared to the manually planned layout and to the results generated by a combined version of the genetic algorithm and tabu search. The results indicate that the RL approach is capable of improving the manually planned layout significantly. Furthermore, it reaches comparable results for the throughput time and better results for the clarity of the material flow compared to the combined version of a genetic algorithm and tabu search.
Effect of surface electroplating on fragment deformation behavior subjected to contact explosion
Authors: meng yuanpei , wang chuanting , ma yue , guo lei , he yuan , jiao junjie , he yong 
Published: April 2023

Abstract

Prefabricated fragments can deform or even fracture subjected to contact explosion. Thus, the surface of the prefabricated fragment was electroplated with Ni, in order to change the fragment deformation behavior. The effect of surface electroplating on the fragment deformation behavior under contact explosion was analyzed. Firstly, explosion recovery experiments were carried out on uncoated and coated fragments, and different lining thicknesses were set for comparison. By observing the recovered samples, the deformation behavior of two kinds of samples was found to change after contact explosion: the uncoated fragments were fractured, while the coated fragments maintained integrity. The lining did not change the fragment deformation behavior but could change the degree of deformation. As the thickness of the lining decreased, the degree of fragmentation compression increased. To study this phenomenon, detonation wave theory and shock wave transmission theory in solids were used to calculate the pressure amplitude variation at the far-exploding surface of the fragments. The pressure amplitude of the uncoated samples instantly dropped to zero after the shock wave passed through the far-exploding surface, which resulted in the formation of tensile zone. But the pressure amplitude of the coated samples increased, which transformed the tensile zone into the compression zone, thereby preventing the fracture of the fragment near the far-exploding surface, which was consistent with the test results. Then, microscopic observation of the circumferential direction of the recovered samples showed that the coatings were better than the lining in preventing "weld melting" and fracture phenomena in the radial direction of the fragments. The test results and theories show that the coating can change the deformation behavior of the fragment and prevent the fracture phenomenon of the fragment. The coating also has better protection performance than the lining against contact explosion.
Grammatical Error Correction with Pre-trained Embeddings and Masked-Language Modeling
Authors: Saha Debartha , Singh Thoudam Doren 
Published: April 2023

Abstract
In recent years, use of pre-trained model for a sequence-to-sequence is becoming quite popular. Many down stream tasks can be benefited from the incorporation of pre-trained model with general language understanding. In our case, we investigate two ways to apply BERT-based pre-trained model for grammatical error correction(GEC) task. BERT has shown its great usefulness in natural language understanding tasks, such as text classification. However, applying BERT to a neural machine translation task as in our case is not straight forward. As training a BERT model is very costly in terms of system resources, fine tuning the model is quite common but using it as a contextual embedding is more challenging. As machine translation output does not generate an annotated data, evaluation of system with respect to each error type can be done only by using ERRANT scorer. So, we also analyze our models with respect to detailed error types with ERRANT scorer.
Molecular Dynamic Simulation Studies on Cyclophilin- a Missing Cord in HIV-1 Capsid Assembly
Authors: Tamalapakula Vani , Jana Sourav Kanti , Som Narayan N. , Jha Prafulla K. , Manga Vijjulatha 
Published: April 2023

Abstract
The discovery of human Cyclophilin A (CyPA) inhibitor is of special interest in treating immunological disorders due to its characteristic protein iterative nature explicitly associated with its peptidyl-prolyl cis-trans isomerization activity. In this work,we have exemplified the significance of the Gly89-Pro90 peptide bond in the N-terminal domain of the capsid protein (CA). The Common Pharmacophore Hypothesis(CPH) AARR has been developed from PHASE, which has shown significant r2 and q2values of 0.923and 0.631 respectively. Molecular docking studies reveal that Gln63, Arg55, Gly72 and Asn102 are the major hitpoints of HIV-1 Capsid His87Ala-Gly-Pro-Ile-Ala92 sequence preferably. Among the six active amino acids, Gly 89 and Pro 90 form major interactions with CyPA which is crucial for HIV-1 infection. This has been confirmed through mutating the respective Gly89 and Pro 90 with Aln (Alanine) residues. New molecules are screened virtually employing CPH template. Further the stability of the protein before and after the ligand binding is examined by molecular dynamics simulation studies using GROMACS. The analysis of RMSD curves and the number of hydrogen bonds are indicating that the ligand N7 (referred as ND1 in Graphical abstract) stably interact with the protein 2CYH with negligible fluctuations around the active site,
Comprehensive Assessment of Occupational Therapy Services in Lady Reading Hospital Peshawar, Pakistan
Authors: Ullah Naseem , Ayub Ayaz , Ullah Ihsan , Hussain Syed Jawad 
Published: April 2023

Abstract

Background:Occupational therapy is the valuation and management of bodily and psychiatric disorders using decided doings to break infirmity and promote an autonomous function in all aspects of daily life. The demand of the consumer increases and partnership of the delivery of the services of occupational therapy. Research evidence support that the patient-centered occupational therapy practice will increase to improve patient and family satisfaction and outcomes measure.Study Objective:To determine the level of patient satisfaction and associated factors from the occupational therapy department of a lady reading hospital Peshawar (LRH), PeshawarMethodology:The study design of the current research was a cross-sectional survey using PSQ 18 and SAPS. The sample size includes 387 participants, who were selected through convenience sampling. The data was analyzed using SPSS version 25.Results:The descriptive analysis of participant satisfaction from occupational therapy services of participants was In a total of 387 participants, Majority of the patients were satisfied, f=175 (45.2%) and very satisfied, f=149 (38.5%) followed by 57 (14.7%) participants that were dissatisfied from the occupational therapy services, respectively. Similarly, the descriptive analysis of participant satisfaction from occupational therapy services via (PSQ-18) of the participants was In a total of 387 participants, Majority of the patients were satisfied, f = 339 (87.6%) followed by 48 (12.4%) patients that were dissatisfied from the occupational therapy services, respectively.ConclusionThis study concluded that occupational services is effective for any health care setup, 87% of people were satisfied from these services so it should be incorporated in the health care system of Pakistan.
Persistent SARS-CoV-2 Infection in a Multiple Sclerosis Patient on Ocrelizumab: A Case Report
Authors: Ambadapoodi Raghava S. , Arnold Forest W. , Chariker Julia H. , Glynn Alex , Lauer William , Marimuthu Subathra , Rouchka Eric C. , Smith Melissa L. , Wolf Leslie A. 
Published: April 2023

Abstract

A 44-year-old female patient with multiple sclerosis (MS) treated with ocrelizumab was hospitalized with SARS-CoV-2 pneumonia three times over the course of five months, eventually expiring. Viral sequencing of samples from her first and last admissions suggests a single persistent SARS-CoV-2 infection. We hypothesize that her immunocompromised state, due to MS treatment with an immunosuppressive monoclonal antibody, prevented her from achieving viral clearance.
Interest-Aware Message Passing Recommender Model based on Graph Convolutional Networks
Authors: connelly merrick , Sinclair Lysandra , Dubois Solenne , Rawlins Galen 
Published: April 2023

Abstract
With the rapid development of deep learning, recommender systems have become an important tool to solve the problem of information overload. Collaborative filtering-based models have made effective progress in learning user and item representations. Graph Convolutional Networks (GCN) have been introduced to extract connection characteristics between users and items, but suffer from over-smoothing issues. This paper proposes an interest-aware message passing recommendation model that uses attention mechanisms and two methods of partitioning graphs to mitigate the over-smoothing problem. The model uses two methods to partition the graph into subgraphs, namely, partitioning the users and items into subgraphs separately. High-order graph convolution operations are performed in the subgraphs to learn user-item node representations based on weak user-item relationships between subgraphs, as well as user-item node representations based on weak item-item relationships between subgraphs, in order to better express users' interests and preferences. By using attention mechanisms, attention weights are added to each layer of the graph neural network to improve the representation of more important layers in the user feature representation.
A Novel Nested Production Function Approach
Authors: Pal Samidh 
Published: April 2023

Abstract
This paper presents a new nested production function that is specifically designed for analyzing capital and labor intensity of manufacturing industries in developing and developed regions. The paper provides a rigorous theoretical foundation for this production function. The analysis shows that the production function can be used to accurately estimate the level of capital and labor intensity in industries, as well as to analyze the capacity utilization of these industries.
JEL Code: L6, L5.
MEDOBO: 18 Million+ MEDLINE Abstracts Tagged with OBO Ontologies
Authors: Aghaebrahimian Ahmad , Anisimova Maria , Gil Manuel 
Published: April 2023

Abstract
Motivation: The number of biomedical and life science publications is rapidly increasing, with MEDLINE alone having over 30 million citations. The massive amount of information highlights the need for biomedical text analytics to improve the accessibility of bio-data. However, the presence of multiple subdomains within life sciences poses a significant challenge. To address this, an automatic classification system is required that can annotate texts with relevant subdomains in a text analytics pipeline. This will make text processing more efficient and precise for subsequent modules in the pipeline by reducing their search space to concepts within a limited set of subdomains. The development of text classification systems for life sciences subdomains requires training data as the first requirement, but unfortunately, a high-quality and large-scale dataset for this task is lacking.
Results: We present MEDOBO, a dataset comprising over 18 million MEDLINE abstracts that have been automatically labeled with ontologies from the Open Biological and Biomedical Ontology (OBO) Foundry using Medical Subject Headings (MeSH). Our dataset has achieved a conformity score of over 91% F1 when compared to an expert-annotated dataset. We have trained multiple models on MEDOBO to evaluate distribution and classification difficulty and the results indicate significant potential for enhancing multi-label text classification.
Epigenetics Mechanism and Therapeutic Potential of Approved Epi-drugs
in Pulmonary Hypertension Disease
Authors: Zhanqiang Li , Huoqiang Huang , Dianxiang Lu 
Published: April 2023

Abstract:
Epigenetics is defined as a heritable change occurring in gene expression and phenotype
without altering the underlying primary DNA sequence itself. Epigenetic variation consists of DNA
methylation repatterning, posttranslational modification of histone proteins, and non-coding RNAs
(ncRNAs). Epigenetic modifications are deeply involved in tumorigenesis and tumor development.
Epigenetic abnormalities can be therapeutically reversed, and three families of epigenetic marks, including
“readers”, “writers” and “erasers”, could be modulated by epi drugs. Over the past decade,
ten small-molecule epi drugs (e.g., inhibitors of DNA methyltransferases and histone deacetylases)
have been approved by FDA or CFDA for the treatment of different cancers. Epigenetics therapy
has been most effective in oncology and has become an attractive area in cancer treatment.

:
Pulmonary hypertension (PH) encompasses a set of multifactorial diseases of progressive cardiopulmonary
disorder. WHO classifies PH into five groups based on similar pathophysiological
mechanisms, clinical presentation, haemodynamic characteristics, therapeutic management, and underlying
etiology. Since PH shows many similarities with cancer, such as proliferation, resistance to
apoptosis, and dysregulation of tumor suppressor genes, the current epigenetics therapeutic strategies
used in cancer might be considered for the treatment of PH. The role of epigenetics in the setting
of PH is a fast-growing field of research. In this review, we have summarized the up-to-date articles
on the role of epigenetic mechanisms in the context of PH. The aim of this review is to provide
a comprehensive insight from the epigenetics perspective and introduce the potential role of
approved epi drugs in PH treatment.
ПОЛІПШЕННЯ ВИКОРСТАННЯ МІОКАРДІАЛЬНИХ ЦИТОПРОТЕКТОРІВ В ЯКОСТІ МЕТАБОЛІЧНОЇ ТЕРАПІЇ ПАЦІЄНТІВ З ДЕКОМПЕНСОВАНОЮ СЕРЦЕВОЮ НЕДОСТАТНІСТЮ В РАННЬОМУ ТА ПІЗНЬОМУ ПОСТІНФАРКТНОМУ ПЕРІОДІ
Authors: Х. В. Левандовська  
Published: April 2023

Серцева недостатність (СН) являється дуже частою, «епідемічною» хворобою цілого світу, яка лягає тяжким тягарем та чинить постійний тиск на систему охорони здоров’я зі значною смертністю, захворюваністю та необхідністю в частих повторних госпіталізаціях.
Декомпенсована СН лишається однією з актуальних проблем сучасної кардіології. У пацієнтів з хронічною СН IV функціонального класу смертність протягом півроку досягає 44 %. Так, після перенесеного епізоду декомпенсації кровообігу протягом наступних 6 місяців повторно зазнають госпіталізації до 50 % таких пацієнтів, а смертність таких хворих досягає 50% протягом найближчого року. З огляду на те, що рівень захворюваності на СН та її декомпенсацію постійно росте, вона залишається серйозною проблемою для національної системи здоров’я. Для поліпшення цієї ситуації необхідне вдо- сконалення диспансерного нагляду та прогнозування перебігу хвороби, від чого можутьзалежати інтенсивність спостереження, тактика та, певною мірою, акценти стратегії лікування. Тому, питання покращення функціонального стану таких пацієнтів, якості життя та виживання є актуальним.
Метою роботи є визначення нових фармакодинамічних ефектів препа- ратів аргініну та янтарної кислоти та їхній вплив на показники відновного періоду після інфаркту міокарда, ускладненого декомпенсованою СН.
У всіх хворих після перенесеного ІМ, ускладненого декомпенсованою СН спостерігали позитивну динаміку щодо зменшення частоти виникнення клінічних ознак декомпенсації СН.
Так, у всіх групах обстежених, як через 1 міс, так і через 2 міс лікування констатована позитивна динаміка на зменшення випадків загальної слабкості, скарг на зниження толерантності до фізичних навантажень та збільшення часу на відновлення після нього.
Про посилення скоротливої здатності ЛШ свідчило зменшення відсотка хворих з протодіастолічним ритмом галопу та послабленням серцевих тонів.

При застосуванні препаратів аргініну та янтарної кислоти на фоні стандартної терапії вказані ознаки зустрічали відповідно у 13 (86,7 %) і 12 (80,0 %) на початку лікування, у 4 (26,7 %) та 5 (33,3 %) через 1 міс терапії і
у 1 (6,7 %) та 3 (20,0%) після 2 міс лікування.
Про позитивний клінічний ефект свідчить і зменшення випадків олігурії та анасарки.
Застосування досліджуваних схем лікування чинило сприятливий вплив на покращення систолічної функції ЛШ, що свідчить про здатність досліджуваних лікарських препаратів нормалізувати показники серцевої гемодинаміки.
Використання у хворих після перенесеного ІМ, ускладненого декомпен- сованою СН, янтарної кислоти та препаратів аргініну дозволяє забезпечити корекцію ряду клініко-патогенетичних ланок захворювання, що, в цілому, сприяє підвищенню ефективності лікування даного контингенту хворих.
Ключові слова: гострий інфаркт міокарда, декомпенсована серцева недостатність, постінфарктний період, янтарна кислота, препарати аргініну.
ВПЛИВ КАРДІОПРОТЕКТИВНОЇ ТЕРАПІЇ У ПАЦІЄНТІВ З ГОСТРИМ ІНФАРКТОМ МІОКАРДА ТА ЦУКРОВИМ ДІАБЕТОМ 2 ТИПУ НА ДИНАМІКУ ЕХОКАРДІОГРАФІЧНИХ ПОКАЗНИКІВ
Authors: М. В. Бєлінський  , Н. М. Середюк  
Published: April 2023

Гострий інфаркт міокарду (ГІМ) є однією з провідних причин смертності дорослого населення в Україні та світі серед усіх серцево-судинних за- хворювань. Дуже часто ГІМ виникає у пацієнтів з різноманітними коморбідними станами. Саме цукровий діабет 2 типу (ЦД 2 типу) є частим супутнім захворюванням пацієнтів з ГІМ. З метою зменшення проявів оксидативного стресу у пацієнтів з такою коморбідністю вико- ристовується кардіопротективна терапія. Найпоширенішими сполуками, які застосовуються з кардіопротективною метою є молекули кверцетину і аденозину. Метою дослідження є підвищення ефективності лікування пацієнтів з ГІМ в поєднанні із цукровим діабетом 2 типу шляхом кардіо- протекції з використанням кверцитину та аденозинвмісного препарату адвокард. У дослідження включено 60 пацієнтів із ГІМ та ЦД 2 типу. Пацієнти були розділені на 2 групи: контрольна група отримувала базову терапію ГІМ та ЦД 2 типу. Пацієнтам основної групи додатково до базової терапії призначався кверцетин (4,5 г внутрішньовенно впродовж 5 днів) та адвокард за схемою. В ході дослідження ми досліджували ехокардіографічні показники. За даними нашого дослідження, застосування кверцитину та аденозвмісного препарату авдокард веде до покращення систолічної функції лівого шлуночка, сприяє зворотньому ремоделюванню лівого шлуночка.
Застосування кардіопротективних засобів кверцитину та аденозин- вмісного препарату адвокард призводить до покращення систолічної функції ЛШ, глобальної скоротливості ЛШ, сприяє зворотньому ремоделюванню ЛП та ЛШ. Не виявлено статистично достовірної різниці впливу досліджуваних препаратів на діастолічну функцію ЛШ.
Ключові слова: гострий інфаркт міокарда, цукровий діабет 2 типу, спекл-трекінг ехокардіографія, кардіопротективна терапія, систолічна дис- функція лівого шлуночка.
Handling Public Well-being During the COVID-19 Crisis: Empirical Study With Representatives From Municipalities in Sweden
Authors: Alaqra Ala Sarah , Khumalo Akhona C 
Published: April 2023

Background
COVID-19 has had a significant impact on the public’s health and well-being due to infections and restrictions imposed during the crisis. Recreational activities are important for the public’s well-being; however, the public’s safety from the COVID-19 virus is the top priority. Sweden, a country with a decentralized public health and welfare system, relied on less stringent approaches for handling the crisis. The limited restrictions in Sweden allowed recreational activities to take place despite the pandemic, which could be attributed to considerations for the public’s well-being.

Objective
The objective of this study was to investigate municipal approaches for handling and supporting recreational activities during the COVID-19 crisis.

Methods
We conducted an empirical study (qualitative and quantitative), using an online survey for data collection, with 23 participants. They were representatives holding mostly managerial roles in 18 distinct municipalities (18 counties). A thematic analysis was conducted to analyze open-ended responses, and descriptive statistics were used to summarize the closed-ended responses.

Results
In this study, we report on the status of municipalities during the COVID-19 pandemic. The highlighted results showed a significant impact on the municipalities as a result of COVID-19, where 78% (18/23) of participants stated significant changes due to the pandemic. Moreover, 91% (21/23) indicated efforts and approaches for supporting recreational activities during COVID-19. Following national guidelines for the public’s health and safety was indicated by 78% (18/23) of participants. Information and communications technology (ICT) was considered significant for dealing with COVID-19 according to 87% (20/23) of participants. Our qualitative results further showed details of the public’s health and safety considerations, the efforts to support recreational activities particularly for youth, and the role and requirements of ICT. Challenges relating to the usability of ICT were also highlighted.

Conclusions
Despite the critique of Sweden’s lenient strategy for handling the COVID-19 crisis, our results showed significant considerations for the public’s safety and well-being by the municipalities (regional and local levels) in this study. The Swedish approach to handling the crisis involved trusting the public with safety guidelines in addition to efforts for the public’s safety, supporting the public’s well-being with approaches for maintaining recreational activities, and giving special care to the youth. Despite having technological solutions in place, challenges in using digital solutions and requirements for future development were noted.