bluuebunny/crossref_metadata_2025_split huggingface dataset:
IN THE WEEDS: UNDERSTANDING CANNABIS USE AMONG OLDER ADULTS
Authors: Sheck Isabelle , Versey H Shellae 
Published: December 2022

Abstract
The existing literature from the past decade shows an increase in the prevalence of cannabis use among older adults (OA) aged 50-65. Most commonly, studies have reported OA using cannabis to manage symptoms related to chronic pain, arthritis, insomnia or disordered sleep, and anxiety. Recent recreational cannabis legislation in several states has also contributed to increasing rates of cannabis use among older adults. Despite an increase in recreational and medicinal cannabis consumption, few studies have focused on cannabis attitudes and behaviors among older adults. Within the past ten years, studies reporting cannabis behavior have been limited to samples of younger adults. This paper provides a comprehensive review of qualitative and quantitative studies of cannabis use among older adults (OA). Additional research detailing the characteristics of cannabis use among OA is needed, including frequency, motivation, type of cannabis (medicinal/recreational), route of administration, suppliers, and social networks associated with cannabis use. This systematic review adds to our knowledge about aging and substance use addressing a gap in the literature regarding drivers of cannabis use among OA. Implications of this research extend to gerontological, public health, and community research as cannabis continues to become more easily accessible in various states.
TOPICS ADDRESSED IN CENTENARIAN RESEARCH: A SCOPING REVIEW OF PUBLICATIONS SINCE 2000
Authors: Jopp Daniela , Lampraki Charikleia , Uittenhove Kim , Delhaes Flavien , Zaccaria Daniele , Da Rocha Carla Gomes , Ziade Garnelle , Becker Melanie 
Published: December 2022

Abstract
Over the past decades, centenarians have increasingly attracted the attention of the research community. This development reflects the constant rise of the numbers of very old individuals, but also the need to better understand longevity mechanisms and what characterizes life at age 100. This scoping review provided an overview of trends in centenarian research from all disciplines since 2000, and identified the most frequently mentioned and neglected topics. Scientific articles meeting the following eligibility criteria were included: (1) publication between 2000 and 2021; (2) in English, French or German language; (3) study population of at least 95 years of age on average, or, for studies with larger age ranges, provision of specific insights for the 95+ group. Following the standard procedures for scoping reviews, we identified a total of N = 3955 articles. After removal of duplicates and exclusion due to unmet criteria, we used content coding to identify research themes of N = 1117 articles. Data confirmed that research articles offering findings on centenarians have increased substantially over the past two decades. Content coding led to 37 main topics: Most frequently, studies addressed higher-order topics such as physical, biological, and mental (e.g., cognitive), which were mostly investigated within disciplinary boundaries. Few multidisciplinary articles examined content domains in conjunction. The least investigated topics in centenarian research included the sub-domains of pain, stress, anxiety, and psychiatric disorders. In sum, findings inform the research community about the existing centenarian research, suggest that multidisciplinary publications are infrequent, and offer guidance for future studies.
MODELS OF OLDER ADULT GROUP ENGAGEMENT TO IMPROVE HEALTH MANAGEMENT
Authors: Hynes Mary , Anderson Nicole , Kastner Monika , Astell Arlene 
Published: December 2022

Abstract
We are studying the use of peer-to-peer group intervention as a means of promoting older adult health self-efficacy and self-management. To explore how older adults have worked together to improve health behaviors, a scoping review was conducted of older adult peer coaching in health maintenance or health improvement groups. Seventeen studies met all search criteria, including interventions examining the value of peer support in self-management of diabetes, a peer led program for fear of falling, and the effect of self-help groups on quality of life. Two models of peer engagement were identified: peer support and mutually supportive environments. Ten studies trained older adults to be peer mentors or leaders with training periods varying from two days to 30 weeks, although many did not include details of the training. The other seven studies examined mutually supportive environments for peer engagement such as a clinician-led with peer-support model, an app-based program with a social support component, and a prevention focused mutual support group. These studies included research comparing self-care and quality of life results after self-help group therapy and a study that analyzed the impact and role of volunteering at a seniors’ centre on maximizing member self-efficacy. While all studies reported on peer self-health engagement, there were many different goals ranging from evaluating health improvement programs to comparing peer and professional health group leadership. One consistent theme was improved perceived self-efficacy though peer group engagement.
TECHNOLOGY USE AMONG OLDER CHINESE ADULTS: BENEFITS ON SUBJECTIVE WELL-BEING
Authors: Yeung Dannii , Chow Natalie , Chung Edwin 
Published: December 2022

Abstract
The growth of Information and Communication Technology (ICT) in recent years has led policy-makers and researchers to look into how these developments affect older adults’ daily lives. The educational attainment of older people in Hong Kong is relatively low, with more than 60% of them only completing primary education or having no formal education. Therefore, their utility of ICT remains low as compared with that of their Western counterparts. One of the objectives of this study is to understand the usage of various forms of ICT among older Chinese adults, including technology use in social, financial, medical, and leisure domains. This study also investigates whether social technology use (such as social media, instant messages, video call) could contribute to better subjective well-being through enhancing their social support. A total of 452 older adults joined this study (M=68.7 years, SD=6.27, Range=60-89; 66.7% female). Among the four domains of ICT, higher usage was observed in the social and leisure domains, particularly among the young old. However, among the participants aged 75 and above, more than 70% of them did not use any form of ICT due to a lack of ICT knowledge. The mediation analyses reveal significant indirect effects of social technology use on life satisfaction (B=0.19, SE= 0.08, p=.010) and positive emotions (B=0.02, SE=0.02, p=.014) through social support, thereby suggesting that social technology use could increase older adults’ perceived support from friends, which subsequently improves their life satisfaction and positive emotions. Practical implications of these findings will be discussed.
IMPLEMENTING A HYBRID TELEHEALTH HOME-BASED TRANSITIONAL CARE PROGRAM: PRE-IMPLEMENTATION CHALLENGES
Authors: Penney Lauren , Damush Teresa , Bravata Dawn , Schubert Cathy , Preddie Alaina , Baird Sean , Schwartzkopf Ashley 
Published: December 2022

Abstract
The reach of home-based clinical programs for medically complex, older adults can be limited by geographic scope. Implementing telehealth versions can expand reach but create constraints for comprehensive assessments and technological barriers for users. We describe challenges and lessons learned during the pre-implementation period for the randomized trial of a hybrid video -modality of the Geriatrics Resources for Assessment and Care for Elders (GRACE) Program at the Indianapolis Veterans Health Care System. In TeleGRACE, a health technician makes home visits to facilitate clinical activities (e.g., medication reconciliation) using telehealth technology for a clinical team (social worker, nurse practitioner) who conduct the visits remotely. Data used in this one-year pre-implementation evaluation included: periodic reflections with the clinical and evaluation staff, planning and interdisciplinary team meeting fieldnotes, and interviews with clinical team members. Data were summarized by selected constructs from the Consolidated Framework for Implementation Research; implementation challenges and problem solving were identified. Pre-implementation challenges occurred in: assuring assessment devices worked correctly for and were trusted by staff (e.g., connectivity, virtual stethoscope), technician fit with existing GRACE team, ensuring technician welfare (e.g., COVID-19 exposure, guns in the home), caseload balance amid staffing shortages, travel logistics, and sampling to adequately power the trial. Building on an existing strong team dynamic and a culture of feedback for quality improvement, challenges were addressed through pilot-testing, monitoring for barriers and impacts, and group reflecting conversations. Adaptations to the initial plan resulted in a more focused and targeted implementation effort to test the model and its effectiveness.
DIGITAL PHENOTYPING TO UNDERSTAND HEALTH-RELATED OUTCOMES: A SCOPING REVIEW
Authors: Lee Kyungmi , Kumar Sidharth , Puga Frank , Azuero Andres , Kamal Arif , Pickering Carolyn , Dionne-Odom J Nicholas 
Published: December 2022

Abstract
Modeling passive data collected by smartphones, or digital phenotyping, may help detect the early signs of declines in daily health and lead to steps to prevent declines. Health-related outcomes have been typically acquired through self-report measures, however this broad approach has several limitations, such as recall and social desirability bias. A potential solution is digital phenotyping. Guided by the Arksey and O’Malley methodological framework, the aim of this scoping review was to identify studies that modeled passive smartphone-sensor data into behavioral markers that correlate or predict health-related outcomes. A literature search of peer-reviewed or conference studies in PubMed, Scopus, Compendex, and HTA yielded 3,170 articles. 40 studies met the inclusion criteria. Studies were organized and assessed for their: 1) data collection approaches (e.g., smartphone passive sensor data and questionnaire), 2) feature extraction (e.g., converting bedtime or wake time into sleep), 3) data analytics (e.g., identifying accelerometer data into sleep patterns using machine learning), 4) behavioral markers, which is observing the activity pattern for an extended period of time and then modeling the activities into appropriate behaviors, and 5) health-related outcomes. The findings of this study demonstrate how to transform passive smartphone-sensor data into behavioral markers that correlate or predict health-related outcomes, which could provide information for more grounded predictive use and successful implementation of digital phenotyping in future research.
REMEMBER STUFF: A PILOT FEASIBILITY TRIAL OF DYADIC-FOCUSED TECHNOLOGY TO SUPPORT PEOPLE WITH ADRD
Authors: Manoharan Sneha , Schroeder Matthew , Slaven James , Higbie Anna , Mullholand Mary Ellen , Fowler Nicole 
Published: December 2022

Abstract
Technology to support caregivers of people with Alzheimer’s disease or related dementias (ADRD) with tasks may be the next frontier for caregiving research. This single-arm 90-day pilot trial tested the usability, feasibility, and acceptability of a software system called RememberStuff® (R/S) by Eperture. We also tested R/S’s impact on caregiver burden. R/S includes a web-based portal where caregivers add information to a touch screen used by patients. R/S is organized around four main features– Calendar, Messaging, Activities, and Remember, a personalized task list. We collected data from dyads at baseline, 30-, 60-, and 90-days. Measures included the Healthy Aging Brain Care (HABC) monitor, System Usability Scale (SUS), and satisfaction scales indicating caregiver’s willingness to use and behavioral intention. We approached caregivers of patients with ADRD seen in primary care clinics. Of the 469 participants reached, 278 (59.28%) refused, 156 (33.26%) were ineligible due to nursing home placement and 35 dyads were enrolled (7.46%). Among enrolled participants, 65.7% completed data up to 90 days. 73.5% of the caregivers lived with the patients. Mean caregiver age was 59.1 years; 67.7% are female; 88.2% are white. Willingness to use R/S was consistent across time from 30 days (M=3.9, SD=0.7) through 90 days (M=3.8, SD=1.1), while usability decreased (30 days M=57.7, SD=7.5 to 90 days M=54.9, SD 8.7). Caregiver’s overall HABC monitor also decreased from baseline (M=29.0, SD=13.1) to 90 days (M=27.2, SD=12.2) indicating less burden at 90 days. These findings support the feasibility of R/S technology to support caregivers of people with ADRD.
EXPLORING COMMUNICATION DISPARITIES IN LATE OLD AGE THROUGH THE LENS OF COMMUNICATION INFRASTRUCTURE THEORY
Authors: Leach Carrie , Jankowski Thomas 
Published: December 2022

Abstract
Health disparities are driven, in part, by communication disparities. Those who face the greatest health burdens often have the least communication resources to draw on to help them to manage and cope. As part of a multi-year, multi-level community engaged study to understand how to reduce the communication disjuncture between community-based service providers and older adults age 75 and older, we draw on data collected from 1,609 older adults through in-depth interviews (n=20) and a random sample survey (n=989) in one county in Michigan, along with a random digit dial telephone survey (n=600) conducted statewide. Findings point to key channels for disseminating information to hard-to-reach older adults being healthcare professionals and home delivered mail. Despite optimistic reports that technology usage and adoption rates are increasing for older users, findings suggest that old adults continue to face digital exclusion. Challenges with connecting through interpersonal networks are discussed. Limited resources for connecting with others through technology combined with increased social distancing due to the pandemic may exacerbate older adults’ diminishing social networks and dwindling communication resources to draw upon for managing their health in later old age. Understanding how to connect with the hard-to-reach is pressing particularly as connecting via tele-health normalizes. This information may be employed to inform strategies for disseminating information to older adults, including those ages 75 and older who are hardest-to-reach, and likewise, outreach and recruitment by researchers to engage them in studies that aim to reduce health disparities.
HOW INTERPLAY BETWEEN INFLAMMASOME AND MIRNA IS ASSOCIATED WITH ALZHEIMER’S DISEASE
Authors: Yashin Anatoliy , Wu Deqing , Arbeev Konstantin , Kulminski Alexander , Stallard Eric , Mengel-From Jonas , Bagley Olivia , Ukraintseva Svetlana 
Published: December 2022

Abstract
The results of recent analyses showed that neuroinflammation—a key contributor to Alzheimer’s disease (AD)—is activated by protein complexes known as inflammasomes. The NLRP3 inflammasome protein complex is mostly studied in the central nervous system; it includes a protein encoded by the NLRP3 gene. Connections between inflammasomes, neuroinflammation, and AD may be regulated by small non-coding RNAs called microRNAs. These molecules have multiple ways to influence AD. For example, microRNA miR-107 may influence AD through regulation of the BACE1 gene expression involved in Aβ production. It remains unclear whether interplay of miR-107 and NRLP3 is associated with AD and whether mechanisms of such interplay differ among participants of LLFS and other studies. To address these questions, we evaluated associations with AD of interactions between genetic variants (SNPs) located in DNA encoding miR-107 and NLRP3 in participants of the LLFS and Framingham Heart Study using a logistic regression model with an interaction term. The facts that both datasets deal with data on related individuals and that many SNPs from either miR-107 or NLRP3 are in linkage disequilibrium were accounted for in these studies. The analysis of the Framingham data showed that the association with AD of the interaction between SNPs from miR-107 and the NLRP3 gene was statistically significant(p=6.71E-03; Bonferroni correction=7.14E-03). The association of the same interaction with AD was replicated in the analysis of LLFS data. These results indicate that in addition to regulating BACE1 expression and Aβ production, miR-107 may influence AD in interaction with the NLRP3 gene.
NEUROCORRELATES BETWEEN THEORY-OF-MIND AND BILINGUALISM IN GRAY MATTER VOLUME OF YOUNG AND OLDER ADULTS
Authors: Yow W Quin , Li Xiaoqian , Ng Kwun Kei , Koi Janice Jue Xin , Zhou Juan Helen 
Published: December 2022

Abstract
The experience of being bilingual may accrue cognitive reserve against age-related declines in older adults. Early bilingualism, e.g., second language age-of-acquisition (L2AoA), has been shown to be associated with better theory-of-mind (ToM) performance in older adults (Yow et al., 2021). Here, we aim to understand the brain structural correlates associated with bilingualism and ToM performance in normal aging. Forty-six young (YA, aged 19-30, M=21.87) and 51 older adult bilinguals (OA, aged 54-77, M=63.61) completed 1) ToM assessments, where they viewed vignettes and answered questions about the protagonists’ mental states, 2) an anatomical MRI scan, 3) a demographic questionnaire including L2AoA and years of education, and 4) a general cognitive ability assessment by the Montreal Cognitive Assessment (MoCA) test. As expected, ANCOVA on ToM composite scores revealed a significant main effect of age – YA showed better ToM performance than OA, F(1,93)=9.48, p=.003, controlling for education and MoCA scores. Importantly, MRI data were preprocessed to obtain gray matter volume (GMV), proxy of neuronal density, of 430 brain regions. Partial least square correlation analysis identified one significant multivariate pattern linking individual differences in GMV with ToM score and L2AoA (48.7% covariance explained, p=.014). Regardless of age, larger GMV in several regions including prefrontal, frontal, medial temporal, and superior temporal cortices were associated with earlier L2AoA (p=.003) and higher ToM score (p=.004), indicating shared variance between ToM and L2AoA in brain morphology. Findings suggest that earlier bilingual acquisition might promote brain maturation that would preserve ToM ability well into later stages of life.
ELECTIVE TELEMEDICINE: ARE OLDER WOMEN IN THE POSTPRIMARY TREATMENT PHASE OF EARLY BREAST CANCER INTERESTED?
Authors: Buse Caroline , Nyrop Kirsten , Kelly Erin O'Hare , Muss Hyman 
Published: December 2022

Abstract
Explosive growth in the use of telemedicine occurred during the COVID-19 pandemic. Telemedicine has the potential to lessen healthcare burden for older adults with frequent appointments, physical and cognitive disabilities, and reliance on caretakers. To benefit from telemedicine, patients must have the capacity to engage with technology, for which inexperience and access may pose barriers. This study aimed to better understand the perspectives of older women with non-metastatic breast cancer on telemedicine, in regards to visit convenience, completeness, and interpersonal satisfaction. In this qualitative study, semi-structured interviews were conducted in a convenience sample of women age 65+, post-primary treatment for Stage I-III breast cancer, who received in-person outpatient care at NC Cancer Hospital before transitioning to telemedicine after March 2020. Patients were interviewed about their perceptions of telemedicine (telephone, video) as compared to in-person visits. Audio files of interviews were transcribed and reviewed to identify themes established a priori in the interview protocol. 15 patients (telephone=5, video=10) were consented and interviewed (July-October 2021), mean age=74. 13/15 participants reported that they preferred a hybrid care model that included telemedicine care over in-person care alone. COVID-19, physical disability, and transportation burden were associated with telemedicine preference. Comfort with familiar patient-provider interaction and lack of physical exam were associated with in-person appointment preference. Patient-clinician conversations and clinic protocols guiding use of telemedicine should take into account newness of diagnosis, patient comfort and familiarity with the care team, travel burden, disability, and whether the physical exam is or is not essential.
"HOW WILL I LIVE THIS LIFE I AM TRYING TO SAVE?": EXPLORING DUALITIES IN CANCER SURVIVORSHIP EXPERIENCES IN NIGERIA
Authors: Nwakasi Candidus , Esiaka Darlingtina , Chidebe Runcie , Fatai Khadijat Banwo , Orji Gloria 
Published: December 2022

Abstract
Objectives. Cancer mortality rate is high in Nigeria with about 102,000 new cases and 72,000 deaths per year. Cancer incidence rate is projected to increase with its rapidly aging population and growth — emphasizing its growing cancer burden. Due to Nigeria’s weak health system, limited cancer therapy and expert oncological services, lack of cancer education and awareness, and sub-optimal implementation of its national cancer control plan, there is an increase in the risk of poor outcomes from cancer. To further understand the mechanism behind the poor outcomes, we explored cancer survivorship experiences of breast cancer survivors in Nigeria. Methods. The study employed a qualitative descriptive method. Semi-structured interviews were conducted with a purposive sample of 30 female breast cancer survivors in Abuja, Nigeria (Mage = 42 years). Their responses were transcribed, coded, and analyzed for themes. Results. The four major themes identified were: 1) life after cancer diagnosis (hope vs despair), 2) faith and religion (coping with faith vs issues with religion), 3) accessing cancer therapy (alternative therapy vs orthodox therapy), and 4) relationship with medical providers (encouragement from medical providers vs hinderance from medical providers). Discussion. Cancer death rates may be high but there is also a growing number of survivors in Nigeria. It is crucial to improve the health and well-being of Nigerians from the time of diagnosis until end of life, thus, the focus of cancer survivorship. The findings point to the critical need for policies to help strengthen cancer survivorship in Nigeria.
CANCER SURVIVORSHIP, AGING, AND SEXUAL HEALTH: GENDERED EXPERIENCES OF SEXUAL BEHAVIOR AND BODY IMAGE
Authors: Ciaralli Spencier , Deimling Gary , Burnham Dyanna , Kavanagh Colleen 
Published: December 2022

Abstract
Previous research on aging has studied sexual health as well as cancer. However, less is known about the intersections of cancer survivorship, aging, and sexual health, particularly as it pertains to the gendered experiences of body image. The select studies available that consider the role of sex and intimacy after cancer have provided wholly quantitative or qualitative analyses. This study provides a mixed-methods approach of cancer survivorship and aging as it pertains to sexual health, particularly examining prostate, colorectal, and breast cancer survivors. In their narratives as to how cancer has influenced their sexual behavior, female breast cancer survivors construct their experiences around body image satisfaction. Men who are prostate cancer survivors note struggles around “performance” and impotence. Common issues for both men and women with colorectal cancer survivorship identify body image and impotence as affecting their sexual behavior. An underlying theme throughout all aging cancer survivors’ narratives is the role of relationships and the perceptions of their partner. Race, marital status, and education are also examined. The data analyzed are from an NCI funded, 10-year longitudinal study based on in-person interviews with 321 cancer survivors. The findings illustrate the importance of medical professionals providing wholistic after-care that is inclusive of aging survivors’ sexual health, relationships, and perception of self.