bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case Report of Brain abscess due to Prevotella oris and Review of the Literature
Authors: Yue Wei , Li Chenlu , Lv Chaonan , Yu Miao , Zhang Yajing , Ling Ling 
Published: February 2023

Abstract
Background
Brain abscess caused by Prevotella oris is rarely reported. Here we described a case of brain infection from Prevotella oris detected by the metagenomic next-generation sequencing (mNGS).
Case presentation
A 63-year-old man with no medical history reported headache in the right frontotemporal region, fever, and intermittent diplopia. Magnetic resonance imaging (MRI) revealed abnormal signals and enhancement changes in sellar region, superior sellar region. mNGS testing showed that the cerebrospinal fluid collected from spinal was detected positively for Prevotella oris. After receiving the combined treatment of antibiotic therapy, the patient recovered well.
Conclusion
We review the relevant literature and try to summarize the characteristics and prognosis of bacterial infection, to provide ideas for clinicians to diagnose and treat disease.
Priming locomotor training with transspinal stimulation in people with spinal cord injury: study protocol of a randomized clinical trial
Authors: Skiadopoulos Andreas , Famodimu Grace O. , Solomon Shammah K. , Agrawal Parul , Harel Noam Y. , Knikou Maria 
Published: February 2023

Abstract
Background: The seemingly simple tasks of standing and walking require continuous integration of complex spinal reflex circuits between descending motor commands and ascending sensory inputs. Spinal cord injury greatly impairs standing and walking ability, but both improve with locomotor training. However, even after multiple locomotor training sessions, abnormal muscle activity and coordination persist. Thus, locomotor training alone cannot fully optimize the neuronal plasticity required to strengthen the synapses connecting the brain, spinal cord, and local circuits and potentiate neuronal activity based on need. Transcutaneous spinal cord (transspinal) stimulation alters motoneuron excitability over multiple segments by bringing motoneurons closer to threshold, a prerequisite for effectively promoting spinal locomotor network neuromodulation and strengthening neural connectivity of the injured human spinal cord. Importantly, whether concurrent treatment with transspinal stimulation and locomotor training maximizes motor recovery after spinal cord injury is unknown.
Methods: Forty-five individuals with chronic spinal cord injury are receiving 40 sessions of robotic gait training primed with 30 Hz transspinal stimulation at the Thoracic 10 vertebral level. Participants are randomized to receive 30-minutes of active or sham transspinal stimulation during standing or active transspinal stimulation while supine followed by 30-minutes of robotic gait training. Over the course of locomotor training, the body weight support, treadmill speed, and leg guidance force are adjusted as needed for each participant based on absence of knee buckling during the stance phase and toe dragging during the swing phase. At baseline and after completion of all therapeutic sessions, neurophysiological recordings registering corticospinal and spinal neural excitability changes along with clinical assessment measures of standing and walking, and autonomic function via questionnaires regarding bowel, bladder and sexual function are taken.
Discussion: The results of this mechanistic randomized clinical trial will demonstrate that tonic transspinal stimulation strengthens corticomotoneuronal connectivity and dynamic neuromodulation through posture-dependent corticospinal and spinal neuroplasticity. We anticipate that this mechanistic clinical trial will greatly impact clinical practice because in real-world clinical settings, noninvasive transspinal stimulation can be more easily and widely implemented than invasive epidural stimulation. Additionally, by applying multiple interventions to accelerate motor recovery, we are employing a treatment regimen that reflects a true clinical approach.
Trial registration: ClinicalTrials.gov: NCT04807764; Registered on March 19, 2021.
Investigating the agreement between methods of different precision
Authors: Borga Magnus 
Published: February 2023

Abstract
Background

Agreement between measurement methods is commonly investigated by a so-called Bland-Altman plot which, among other things, shows if the difference between the methods is independent of the size of the measurement. However, such analysis assumes that both methods have the same precision. If not, the plot may show a false trend caused by the difference in precision and not by an actual dependence on the size of the measurement. To solve this problem, we suggest a modification of the Bland-Altman plot such that the differences are plotted against an inverse-variance weighted average of the measurements rather than their mean.

Methods

We show analytically that the proposed modification indeed removes the linear bias component caused by differences in within-subject variance between the methods. We also illustrate the effects of true linear dependency and differences in precision on Bland-Altman plots of synthetic data with and without the proposed modification. Finally, we show the effect of this modification on real data with a significant difference in within-subject variance between the methods.

Results

In contrast to the standard Bland-Altman analysis, the slope of the bias in the synthetic data was correctly estimated by the proposed method. On real data, the linear trend observed in the standard Bland-Altman plot was almost completely removed with the proposed method.

Conclusions

This study shows that the proposed modification of the Bland-Altman analysis removes the false trends caused by differences in precision between the two methods when investigating their agreement.
IGF2BP3 promotes adult myocardial regeneration by stabilizing MMP3 mRNA through interaction with m6A modification
Authors: Zhang Liangqing , Li Simeng , Shen Siman , Xu Hao , Cai Shuyun , Yuan Xiaodong , Wang Changsen , Zhang Xiaojun , Chen Suyun , Chen Jianning , Shi De-li 
Published: February 2023

Abstract
Myocardial infarction that causes damage to heart muscle can lead to heart failure. The identification of molecular mechanisms promoting myocardial regeneration represents a promising strategy to improve cardiac function. Here we show that IGF2BP3 plays an important role in regulating adult cardiomyocyte proliferation and regeneration in a mouse model of myocardial infarction. IGF2BP3 expression progressively decreases during postnatal development and becomes undetectable in the adult heart. However, it is strongly upregulated after cardiac injury. Both gain- and loss-of-function analyses indicate that IGF2BP3 regulates cardiomyocyte proliferation in vitro and in vivo. In particular, IGF2BP3 promotes cardiac regeneration and improves cardiac function after myocardial infarction. Mechanistically, we demonstrate that IGF2BP3 binds to and stabilizes MMP3 mRNA through interaction with N6-methyladenosine modification. The expression of MMP3 protein is also progressively downregulated during postnatal development. Functional analyses indicate that MMP3 acts downstream of IGF2BP3 to regulate cardiomyocyte proliferation. These results suggest that IGF2BP3-mediated post-transcriptional regulation of extracellular matrix and tissue remodeling contributes to cardiomyocyte regeneration. They should help to define therapeutic strategy for ameliorating myocardial infarction by inducing cell proliferation and heart repair.
Knowledge and practice of nurses towards preventing Catheter-related Urinary Tract Infection and its associated factors at the governmental referral hospitals of West Oromia, Ethiopia, 2022. A facility-based cross-sectional study design
Authors: Zewdie Ashenafi , Gebremariam Tesfamichael , Asfaw Sr. Nini , Muche Wondimu , Dessalegne Sr. Alemwork 
Published: February 2023

Abstract
Introduction: Catheter-Associated Urinary Tract Infections have been highly associated with patient discomfort, increased hospitalization and healthcare costs, morbidity and mortality. Lack of knowledge and practice among nurses regarding basic infection control protocols could lead to hospital-acquired infections. Therefore, this study aimed to assess knowledge, practice and associated factors of Catheter-Associated Urinary Tract Infections prevention among nurses working at referral hospitals in the West Oromia region, Ethiopia, 2022.
Methods: A facility-based cross-sectional study was conducted among 423 nurses at five referral hospitals of the West Oromia region from May1-20, 2022. A simple random sampling technique was used to select nurses. A pre-tested and structured self-administered questionnaire was used to collect the data, and then coded and entered into EPI- Data version 4.6; cleaned and analyzed using Stata version 16.0. All variables with P-value < 0.25 in the binary logistic regression analyses were included in the multivariable regression analysis. The degree of the association was interpreted by using the adjusted odds ratio with 95% confidence intervals, and the significance level was declared at P-value < 0.05. The Hosmer–Lemeshow test was checked for the fitness of the model.
Results: Among 423 nurses, 411(97.2%) nurses participated. This study found that the knowledge and practice of nurses toward preventing Catheter-Associated Urinary Tract Infections was 57.9% with 95% CI (53.1, 62.6) and 54.5% with 95% CI (49.6, 59.3) respectively. Good knowledge was significantly associated with working experience [AOR = 2.8, 95% CI (1.5, 5)], training [AOR = 2.1, 95% CI (1.04, 4.2)] and had guideline [AOR = 2.6, 95% CI (1.3, 5.4)]. Good practice was significantly associated with the work experience [AOR = 2, 95%CI (1.05, 4.05)], guideline [AOR = 2.3, 95% CI (1.02, 5.2)], training [AOR = 2.3, 95% CI (1.06, 5.1)] and good knowledge [AOR = 8.7, 95% CI (5.1, 14.8)].
Conclusion: This study showed that more than half of nurses had good knowledge and good practice regarding preventing catheter-associated urinary tract infections, and were significantly associated with work experience, training and guideline.
Individual supported work placements (ReISE) for improving sustained return to work in unemployed people with persistent pain: study protocol for a cohort randomised controlled trial with embedded economic and process evaluations.
Authors: Amundsen Pål André , Underwood Martin , Burton Kim , Grotle Margreth , Malmberg-Heimonen Ira , Kisa Adnan , Småstuen Milada Cvancarova , Holmgard Thor Einar , Martinsen Amy , Lothe Jakob , Irgens Pernille Marie Stähr , Højen Magnus , Monsen Sølvi Spilde , Froud Robert 
Published: February 2023

Abstract
Background
Around one-third of workdays lost in Norway are due to musculoskeletal conditions, with persistent (chronic) pain being the most frequent cause of sick leave and work disability. Increasing work participation for people with persistent pain improves their health, quality of life, well-being, and reduces poverty; however, it is not clear how to best help unemployed people who have persistent pain to return to work. The aim of this study is to examine if a matched work placement intervention featuring case manager support and work-focused healthcare improves return to work rates and quality of life for people in Norway.
Methods
We will use a cohort randomised controlled approach to test the effectiveness and cost-effectiveness of a matched work placement intervention featuring case manager support and work-focused healthcare compared to those receiving usual care in the cohort alone. We will recruit people aged 18-64, who have been out of work for at least one month, had pain for more than three months, and want to work. Initially, all (n= 228) will be recruited to an observational cohort study on the impact of being unemployed with persistent pain. We will then randomly select one in three to be offered the intervention. The primary outcome of sustained return to work will be measured using registry and self-reported data, while secondary outcomes include self-reported levels of health-related quality of life, and physical and mental health. Outcomes will be measured at baseline and three-, six- and 12-months post-randomisation. We will run a process evaluation parallel to the intervention exploring implementation, continuity of the intervention, reasons for participating, declining participation, and mechanisms behind cases of sustained return to work. An economic evaluation of the trial process will also be conducted.
Discussion
The ReISE intervention is designed to increase work participation for people with persistent pain. The intervention has the potential to improve work ability by collaboratively navigating obstacles to working. If successful, the intervention may be a viable option for helping people in this population.
Trial Registration
ISRCTN registry: 85437524 Registered 30/03/2022
Comparable Effectiveness of Organic Mulch and Conventional Insecticides in Managing Sweetpotato Weevils and Millipede on Selected Sweetpotato Varieties
Authors: Rwegasira Gration M. 
Published: February 2023

Abstract
Organic produce have of recent been among the positive outlook for health safety in bids to avoid the bad impact of synthetic insecticides to human and the environment. The use of non-chemical control measures has been practiced on sweetpotato weevils with uncertainty. Very often, farmers either do nothing or rely heavily on synthetic insecticides. Field experiments were conducted from 2015 to 2016 to assess the effectiveness of grass mulch in controlling sweetpotato weevils and millipede on sweetpotato tubers at TARI, Kibaha in Tanzania. Comparison was made with Dimethoate 40EC insecticide and a negative control treatment where no weevil management technique was applied. The treatments were tested on four popular and farmer preferred sweetpotato varieties; Ukerewe, Simama, Mataya and Kiegea established on naturally infested fields. Obtained results suggested that the use of mulch significantly (P < 0.05) increased sweetpotato yield (weight) and but did not reduce Cylas puncticollis infestation on roots. The influence of test varieties on C. puncticollis infestation were highly significant (P < 0.005). The effect of dipping sweetpotato vines into Dimethoate 40EC against C. puncticollis and millipedes prior to planting was insignificant (P > 0.05). Conclusively, neither grass mulch nor Dimethoate 40EC insecticides may offer effective control of sweetpotato weevils in pest endemic areas.
Clinical prediction score for prolonged length of hospital stay in aneurysmal subarachnoid hemorrhage
Authors: Prasetyo Bambang Tri , Kurniawan Ricky Gusanto , Rilianto Beny , Windiani Pratiwi Raissa , Gotama Kelvin Theandro , Salam Sardiana , Sari Ita Muharram , Musridharta Eka , Arham Abrar , Kusdiansah Muhammad , Kiemas Lyna Soertidewi , Bustami Mursyid 
Published: February 2023

Abstract
Background: Length of stay (LOS) is an important indicator for optimizing health services and hospital financing efficiency in aneurysmal subarachnoid hemorrhage (aSAH) patients. The purpose of this study was to develop a scoring model to predict the LOS of aSAH.
Method: The clinical scoring was developed based on retrospectively-collected data from the cerebral aneurysm registry of the National Brain Center Hospital, Jakarta, from January 2019 to June 2022. Multivariate logistic regression was used to determine the odds ratio for risk-adjusted prolonged LOS. LOS’ predictors were obtained based on the regression coefficients and converted into a point score model.
Results: Of the 209 aSAH patients observed, 117 patients had prolonged LOS (>14 days of hospital stay). A clinical score was developed with a range of 0-7 points. Four variables were chosen as predictors of prolonged LOS: presence of high-grade aSAH (1 point), aneurysm treatment (endovascular coiling: 1 point; surgical clipping: 2 points), cardiovascular comorbidities (1 point), and hospital-acquired pneumonia (3 points). The score showed good discrimination with an area under the receiving operating characteristics curve (AUC) of 0.8183 (SE 0.0278) and p-value for the Hosmer–Lemeshow (HL) goodness-of-fit of 0.9322.
Conclusion: This simple clinical score reliably predicted prolonged LOS in aneurysmal subarachnoid hemorrhage cases and may aid clinicians in improving patient outcomes and decreasing healthcare costs.
Exploring elderly patient’s experience and concerns of early ambulation implemented in postoperative care following lumbar spinal surgery: a qualitative study
Authors: Huang Jie , Li Pan , Wang Huiting , Lv Chenxi , Han Jing , Lu Xuemei 
Published: February 2023

Abstract
Background: Given the apparent benefits, the implementation of early ambulation is becoming increasingly important in spinal surgery. The timing for patients first time get out of bed for ambulation after spinal surgery has a wide range. Since Jan 2022, we conducted a study of early ambulation (ambulated within 4h postoperatively) in elderly patients following long-segments lumbar decompression and fusion surgery. In order to better understand elderly patients’ perceptions of the early ambulation, clarify controversies, and ultimately contribute to the improvement of elderly patients’ perioperative experience and also the quality of life, we carried out this qualitative approach.
Methods: A qualitative description design with face-to-face semi-structured interviews was used. Twenty-four patients were enrolled in participating and completing this qualitative investigation from February to June 2022. Interviews were audio-recorded, and content analysis was used for data analysis.
Results: Six themes were identified from this study about patient’s experience and concerns on early ambulation: Worries, Benefits, Daily Routines, Pain, Education and Supports. The findings showed the obstacles in early ambulation practice and highlighted the importance of education on early ambulation in the perioperative hospitalization.
Conclusions: Unequivocal guidance for early ambulation and multidisciplinary ambulation protocol, including comprehensive pain management plan are essential to induce patient education, which may have positive effects on reducing stress and getting rid of anxiety for postoperative early ambulation.
Mediating Effect of Amygdala Activity on Responses to Fear vs. Happiness in Youths with Disruptive Mood and Behavior Disorders
Authors: Suk Jiwoo , Blair R. J. R. , Vaughan Brigette , Lerdahl Arica , Garvey William F. , Edwards Ryan , Leibenluft Ellen , Hwang Soonjo 
Published: February 2023

Abstract
Irritability, characterized by a tendency to exhibit increased anger, is a common clinical problem in youth. This study investigated relationships among irritability, selective impairment in process of facial emotion, and neural responses in amygdala in youth with irritability during implicit emotion processing task under functional MRI (fMRI). Fifty-nine youths with disruptive mood and behavior disorder completed a facial expression processing task with an event-related fMRI paradigm. We found a positive relationship between irritability and RT difference between negative (fear) and positive (happiness) facial expressions. Increased irritability was associated with a longer reaction time toward positive vs. negative facial expressions. Irritability was also positively associated with the difference of amygdala blood oxygen level dependent responses between the two emotional conditions (happiness > fear). This difference in amygdala activity mediated the interaction between irritability and the RT difference between negative and positive facial expressions. We suggest that impairment in the implicit processing of facial emotional expressions with different valences causes distinct patterns of amygdala response, which correlate with the level of irritability.
A High-Sensitivity Ionization Humidity Sensor Based on Carbon Nanotubes
Authors: Zhang Yong , Cheng Zhenzhen , Deng Yuangang , Wang Ruizhe , ALKADHIM Saif aldeen Saad Obayes , Muhammad Waqas , Li Xiaoyu , Wang Chunqi , Wang Shudong , Li Yunjia 
Published: February 2023

Abstract
Monitoring relative humidity accurately is essential for health, comfort, agriculture, food processing, storage, and making electronics. Because of this, it is imperative to know how much water is in different situations and materials in a precise and reliable way. Carbon materials have gained interest in humidity sensing due to their diverse surface chemistry and structural design abilities. Here, a new ionization relative humidity sensor was proposed. It had a carbon nanotube cathode, an extracting electrode, and a collecting electrode. The sensitive mechanism of the humidity sensor is studied based on how water vapor reacts when it collides with ions. The results show that the three-electrode sensor is much more sensitive than the two-electrode, resonant, resistive, and capacitive ionization-based relative humidity sensors. At the same time, the three-electrode humidity sensor has the widest range of detection of all the humidity sensors. At a 90V extraction voltage, single-value sensitive characteristics were obtained in the range of 25–100% RH in nitrogen (N2) and 30–100% RH in air. The maximum sensitivity is 381.67% RH− 1 and 11.83% RH− 1, respectively. Furthermore, the remarkable consistency indicates broad application possibilities of the three-electrode humidity sensor.
Chemical Entity Normalization for Successful Translational Development of Alzheimer's Disease and Dementia Therapeutics
Authors: Mullin Sarah , McDougal Robert , Cheung Kei-Hoi , Kilicoglu Halil , Beck Amanda , Zeiss Caroline J 
Published: February 2023

Abstract

Background: Identifying chemical mentions within the Alzheimer’s and dementia literature can provide a powerful tool to further therapeutic research. Leveraging the Chemical Entities of Biological Interest (ChEBI) ontology, which is rich in hierarchical and other relationship types, for entity normalization can provide an advantage for future downstream applications. We provide a reproducible hybrid approach that combines an ontology-enhanced PubMedBERT model for disambiguation with a dictionary-based method for candidate selection.
Results: There were 56,553 chemical mentions in the titles of 44,812 unique PubMed article abstracts. Based on our gold standard, our method of disambiguation improved entity normalization by 25.3 percentage points compared to using only the dictionary-based approach with fuzzy-string matching for disambiguation. For our Alzheimer’s and dementia cohort, we were able to add 47.1% more potential mappings between MeSH and ChEBI when compared to BioPortal.
Conclusion: Use of natural language models like PubMedBERT and resources such as ChEBI and PubChem provide a beneficial way to link entity mentions to ontology terms, while further supporting downstream tasks like filtering ChEBI mentions based on roles and assertions to find beneficial therapies for Alzheimer’s and dementia.