bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical outcomes and the impact of valve morphology for transcatheter aortic valve replacement in bicuspid aortic valves: A systematic review and meta‐analysis
Authors: Gupta Rahul , Mahmoudi Elham , Behnoush Amir Hossein , Malik Aaqib H. , Mahajan Pranav , Lin Muling , Bandyopadhyay Dhrubajyoti , Goel Akshay , Chakraborty Sandipan , Aedma Surya K. , Gupta Harsh Bala , Vyas Apurva V. , Combs William G. , Mathur Moses , Yakubov Steven J. , Patel Nainesh C. 
Published: August 2023

AbstractBackgroundBicuspid aortic valve (BAV) is present in approximately 0.5%–2% of the general population, causing significant aortic stenosis (AS) in 12%–37% of affected individuals. Transcatheter aortic valve replacement (TAVR) is being considered the treatment of choice in patients with symptomatic AS across all risk spectra.AimAim Our study aims to compare TAVR outcomes in patients with BAV versus tricuspid aortic valves (TAV).MethodsA comprehensive literature search was performed in PubMed, Web of Science, and Cochrane trials. Studies were included if they included BAV and TAV patients undergoing TAVR with quantitative data available for at least one of our predefined outcomes. Meta‐analysis was performed by the random‐effects model using Stata software.ResultsFifty studies of 203,288 patients were included. BAV patients had increased 30‐day all‐cause mortality (odds ratio [OR] = 1.23 [1.00–1.50], p = 0.05), in‐hospital stroke (OR = 1.39 [1.01–1.93], p = 0.05), in‐hospital and 30‐day PPI (OR = 1.13 [1.00–1.27], p = 0.04; OR = 1.16 [1.04–1.13], p = 0.01) and in‐hospital, 30‐day and 1‐year aortic regurgitation (AR) (OR = 1.48 [1.19–1.83], p < 0.01; OR = 1.79 [1.26–2.52], p < 0.01; OR = 1.64 [1.03–2.60], p = 0.04). Subgroup analysis on new‐generation valves showed a reduced 1‐year all‐cause mortality (OR = 0.86 [CI = 0.75–0.98], p = 0.03), despite higher in‐hospital and 30‐day PPI (OR = 0.1.21 [1.04–1.41], p = 0.01; OR = 1.17 [1.05–1.31], p = 0.01) and in‐hospital AR (OR = 1.62 [1.14–2.31], p = 0.01) in the BAV group. The quality of included studies was moderate‐to‐high, and only three analyses presented high heterogeneity.ConclusionTAVR is associated with comparable outcomes in patients with BAV and TAV. Careful selection of BAV cases by preprocedural assessment of valve anatomy and burden of calcification, pre‐ and post‐procedural dilation, and implementing newer generations of valves may improve the safety and efficacy of TAVR in BAV patients.
Structure‐property Relationship of Double Perovskite Oxide towards Trifunctional Electrocatalytic Activity: Strategy for Designing and Development
Authors: Rom Tanmay , Poojita  , Paul Avijit Kumar 
Published: August 2023

AbstractIn the present scenario, the paramount significant roles of various heterogeneous catalysts stimulate the modern technologies to underpin the benchmark requirements for the generation of sustainable energy by reducing toxic fossil fuel emissions. Such critical role necessitates further development of cost‐effective highly efficient and earth‐abundant multifunctional or trifunctional electrocatalysts to promote the advancement of electrochemical overall water splitting performances, yet it is extremely desirable. In this review context, we present the development of double perovskite (DP) oxides as robust trifunctional catalysts for electrochemical oxygen evolution reaction (OER), oxygen reduction reaction (ORR) and hydrogen evolution reactions (HER) by rational design of multiple cationic redox sites with stoichiometric oxygen amount. Particularly, we highlight the importance of the structural modifications via doping, surface structure and oxygen stoichiometry as key parameters to tune the electrocatalytic activities and understand the insight into activity and mechanism of this oxide family. This perspective also describes controlled synthesis protocols including the surface structure of double perovskite oxides are key techniques for realizing a correlation between structure‐activity relationships of these materials. Finally, it is concluded by outlining the several aspects of optimization strategies and computational opportunities can expand the future scope of double perovskite oxides as robust trifunctional electrocatalysts.
Supercritical CO2 Mediated Multi‐scale Structural Engineering in PdCu/C for Boosting Electrocatalytic Formic Acid Oxidation
Authors: Ge Tianpei , Cui Wenhui , Gao Bo , Tian Qingyong , Liu Hongpo , Wu Wenzhuo , Xu Qun 
Published: August 2023

AbstractNowadays, PdCu alloy nanocatalyst with excellent performance in electrocatalytic formic acid oxidation reaction (FAOR) is believed to have great potential in application of direct formic acid fuel cells. Structural engineering has shown great success in achieving PdCu alloys with high catalytic performance, while achievement of multi‐scale structure engineering is still a great challenge. In this work, we found that supercritical carbon dioxide (SC CO2) could lead to multi‐scale structure engineering in PdCu/C nanocatalysts, including surface defect engineering, phase engineering, morphology engineering and substrate structure engineering. With the assistance of SC CO2, amorphous phase in surface, the transformation from face‐centered cubic (FCC) to body‐centered cubic (BCC) phase, the morphology of 2D nanoflakes and the curved carbon as substrate all contribute to the ultrahigh mass activity for electrocatalytic FAOR as 3624.3 mA/mgPd in PdCu/C nanocatalysts, which is the highest value in PdCu alloy reported up to now. Therefore, this work not only displays the great potential of SC CO2 in multi‐scale structure engineering, but also provides new inspiration of material design to achieve nanocatalysts with ultrahigh catalytic performance.
Binary Metallic CuCo5S8 Anode for High Volumetric Sodium‐Ion Storage
Authors: Hui Da , Liu Jingyi Y. , Pan Feilong L. , Chen Nan , Wei Zhixuan X. , Zeng Yi , Yao Shiyu Y. , Du Fei 
Published: August 2023

AbstractWith the rapid improvement of compact smart devices, fabricating anode materials with high volumetric capacity has gained substantial interest for future sodium‐ion batteries (SIBs) applications. Herein, a novel bimetal sulfide CuCo5S8 material is proposed with enhanced volumetric capacity due to the intrinsic metallic electronic conductivity of the material and multi‐electron transfer during electrochemical procedures. Due to the intrinsic metallic behavior, the conducting additive (CA) could be removed from the electrode fabrication without scarifying the high rate capability. The CA‐free CuCo5S8 electrode can achieve a high volumetric capacity of 1436.4 mA h cm−3 at a current density of 0.2 A g−1 and 100 % capacity retention over 2000 cycles in SIBs, outperforming most metal chalcogenides, owing to the enhanced electrode density. Reversible conversion reactions are revealed by combined measurements for sodium systems. The proposed new strategy offers a viable approach for developing innovative anode materials with high‐volumetric capacity.
Intramolecular Through‐Space Double‐Electron Transfer Between A Pair of Redox‐Active Guanidine Units Aligned by Dithiolate Bridges
Authors: Wild Ute , Hübner Olaf , Meiners Paul , Kaifer Elisabeth , Enders Markus , Himmel Hans‐Jörg 
Published: August 2023

AbstractUsing unconventional synthesis protocols, two redox‐active triguanidine units are connected by a dithiolate bridge, aligning the two redox‐active units in close proximity. The reduced, neutral and the tetracationic redox states with two dicationic triguanidine units are isolated and fully characterized. Then, the dicationic redox states are prepared by mixing the neutral and tetracationic molecules. At low temperatures, the dications are diamagnetic (singlet ground state) with two different triguanidine units (neutral and dicationic). At room temperature, the triplet state with two radical monocationic triguanidine units is populated. At low temperature (210 K), chemical exchange by intramolecular through‐space electron‐transfer between the two triguanidine units is evidenced by EXSY NMR spectroscopy. Intramolecular through‐space transfer of two electrons from the neutral to the dicationic triguanidine unit is accompanied by migration of the counterions in opposite direction. The rate of double‐electron transfer critically depends on the bridge. No electron‐transfer is measured in the absence of a bridge (in a mixture of one dicationic and one neutral triguanidine), and relatively slow electron transfer if the bridge does not allow the two triguanidine units to approach each other close enough. The results give detailed, quantitative insight into the factors that influence intramolecular through‐space double‐electron‐transfer processes.
Water‐Dispersible Carbon Nano‐Test Tubes as a Container for Concentrated DNA Molecules
Authors: Hoshikawa Yasuto , Kanno Yasuyuki , Tawata Hanako , Sagae Takuya , Ishii Takafumi , Imoto Shuhei , Hagihara Shinya , Wada Takehiko , Nagatsugi Fumi , Aziz Alex , Nishihara Hirotomo , Kyotani Takashi , Itoh Tetsuji 
Published: August 2023

AbstractInvited for the cover of this issue are Takashi Kyotani, Tetsuji Itoh and co‐workers at Tohoku University, Gunma University and AIST. The image depicts the synthesis of water‐dispersible carbon nano‐test tubes by using a template technique and the selective adsorption of DNA into the inner space of these test tubes. Read the full text of the article at 10.1002/chem.202301422.
Free‐energy lattice Boltzmann simulations of slicing of rising droplets
Authors: Cao Jiawei , Liu Fengjiao , Wang Shipeng , Li Xiang , Zhang Lijuan , Lu Jie , Derksen Jos J. 
Published: August 2023

AbstractWe performed two‐dimensional simulations of the slicing of a rising droplet by a vertical knife and by two knives. We used a free‐energy lattice Boltzmann method. Most simulations are for an Eötvös number of 3.96 and a Morton number of 1.24 ×  . We carefully probed effects of the spatial resolution on the rising speed and slicing process. The effect of wettability of the knife(s) was studied by varying the equilibrium contact angle of the drop on the knife in the range of 45° to 135°. Slicing time as well as fine droplet fragments staying behind on the knife depend on the knife's wettability.
Soilless remediation of the fine carbonate‐rich gold‐copper mine tailings
Authors: Xia Ling , Bi Yujing , Cui Xu , Liu Xu , Zhou Keqiang , Song Shaoxian , Zhu Jiang , Li Hongqiang , Hu Yong 
Published: August 2023

AbstractSoil remediation with minimum amendments is a good strategy for tailings disposal. Carbonate‐rich gold‐copper mine tailings occurring alongside the Yangzi River, China, were employed as the objective in this study. They showed the characteristics of fine particles and alkaline pH with high density and low nutrition. The amendments including bacterial fertilizer (BF), polymer, peat, straw, and compound fertilizer (CF) were used for soilless remediation on the tailings. Soil quality index (SQI) involved in tailing properties and growth characteristics of ryegrass was used to optimize the combination of amendments. The results showed that the optimum amendment combination was 0.2% BF + 0.6% CF + 0.2% polymer + 10% peat and 2% straw. Tailing nutrients such as soil organic matter (5.56%), available nitrogen (93.6 mg kg−1), available phosphorus (51.7 mg kg−1), available potassium (711 mg kg−1), and ryegrass exhibited the highest germination rate and biomass level under the optimal improvement conditions. Additional environmental assessments revealed that soilless treatment of the tailings helped to convert Cu, Zn, and As into residual forms. These findings show a good strategy for tailings soil improvement and provide a promising perspective of the soilless remediation for fine carbonate‐rich metal tailings.
Advancing immunotherapy in small cell lung cancer
Authors: Carlisle Jennifer W. , Leal Ticiana 
Published: August 2023

AbstractSmall cell lung cancer (SCLC) is a rapidly progressive neuroendocrine carcinoma that, until recently, had a very small armamentarium of effective treatments. Advances in DNA sequencing and whole transcriptomics have delineated key subtypes; therefore, SCLC is no longer viewed as a homogeneous cancer. Chemoimmunotherapy with PD1 blockade is now the standard of care for advanced disease, and ongoing research efforts are moving this strategy into the limited stage setting. Combination strategies of immunotherapy with radiation are also under active clinical trial in both limited and extensive stage disease.Plain Language Summary

Small cell lung cancer (SCLC) is a rapidly progressive neuroendocrine carcinoma that, until recently, had a very small armamentarium of effective treatments.
Chemoimmunotherapy with immune check point inhibitors is now the standard of care for advanced disease.
This comprehensive review provides an overview of current treatment strategies for SCLC, unmet needs in this patient population, and emerging treatment strategies incorporating immunotherapy that will hopefully further improve outcomes for patients.
Prevention and management of drug‐induced osteonecrosis of the jaws using platelet‐rich fibrin: A clinical feasibility study
Authors: Alrmali Abdusalam , Saleh Muhammad H. A. , Kurdi Salaheddin Mohamed S. , Sabri Hamoun , Meghil Mohamed M. , Wang Hom‐Lay 
Published: August 2023

AbstractObjectiveAlthough a standard treatment guideline has not been established to date, various treatment modalities have been described in the literature based on the staging of medication‐related osteonecrosis of the jaw (MRONJ). The aim of this case series was to describe the outcomes of surgical intervention of MRONJ cases with the adjunctive use of platelet‐rich fibrin (PRF).Materials and MethodsThirteen patients under therapy with zoledronic acid, seven of them underwent surgical removal of necrotic bone with debridement, followed by placement of three to four PRF membranes and achieving primary closure. In six patients, PRF was used preventively to avoid MRONJ.ResultsThe surgical treatment outcomes were successful in all patients, with a follow‐up range of 12–48 months. In the presented cases, the intraoral evaluation showed excellent soft tissue healing except for one patient secondary wound healing was reported. Additionally, there was no recurrence of bone exposure in all cases. PRF membranes were comparatively effective in postsurgical pain control.ConclusionThe use of PRF could represent a valuable adjunct in the surgical management for advanced stages of MRONJ cases.Clinical RelevanceThis clinical case series describes the use of PRF membranes as a valuable adjunct in the surgical management of MRONJ patients, especially when treating advanced MRONJ cases. Moreover, PRF demonstrates usefulness in preventing such difficult complications from occurring.
CsPbBr3 Perovskite Nanocrystals for Photocatalytic [3+2] Cycloaddition
Authors: Lin Yixiong , Yan Yong 
Published: August 2023

AbstractVisible‐light‐induced halide‐exchange between halide perovskite and organohalide solvents has been studied in which photoinduced electron transfer from CsPbBr3 nanocrystals (NCs) to dihalomethane solvent molecules produces halide anions via reductive dissociation, followed by a spontaneous anion‐exchange. Photogenerated holes in this process are less focused. Here, for CsPbBr3 in dibromomethane (DBM), we discover that Br radical (Br⋅) is a key intermediate resulting from the hole oxidation. We successfully trapped Br⋅ with reported methods and found that Br⋅ is continuously generated in DBM under visible light irradiation, hence imperative for catalytic reaction design. Continuous Br⋅ formation within this halide‐exchange process is active for photocatalytic [3+2] cycloaddition for vinylcyclopentane synthesis, a privileged scaffold in medicinal chemistry, with good yield and rationalized diastereoselectivity. The NC photocatalyst is highly recyclable due to Br‐based self‐healing, leading to a particularly economic and neat heterogeneous reaction where the solvent DBM also acts as a co‐catalyst in perovskite photocatalysis. Halide perovskites, notable for efficient solar energy conversion, are demonstrated as exceptional photocatalysts for Br radical‐mediated [3+2] cycloaddition. We envisage such perovskite‐induced Br radical strategy may serve as a powerful chemical tool for developing valuable halogen radical‐involved reactions.
Role of miR‐15a‐5p and miR‐199a‐3p in the inflammatory pathway regulated by NF‐κB in experimental and human atherosclerosis
Authors: González‐López Paula , Álvarez‐Villarreal Marta , Ruiz‐Simón Rubén , López‐Pastor Andrea R. , de Ceniga Melina Vega , Esparza Leticia , Martín‐Ventura José L. , Escribano Óscar , Gómez‐Hernández Almudena 
Published: August 2023

AbstractBackgroundCardiovascular diseases (CVDs) prevalence has significantly increased in the last decade and atherosclerosis development is the main trigger. MicroRNAs (miRNAs) are non‐coding RNAs that negatively regulate gene expression of their target and their levels are frequently altered in CVDs.MethodsBy RT‐qPCR, we analysed miR‐9‐5p, miR‐15a‐5p, miR‐16‐5p and miR‐199a‐3p levels in aorta from apolipoprotein knockout (ApoE−/−) mice, an experimental model of hyperlipidemia‐induced atherosclerosis, and in human aortic and carotid atherosclerotic samples. By in silico studies, Western blot analysis and immunofluorescence studies, we detected the targets of the altered miRNAs.ResultsOur results show that miR‐15a‐5p and miR‐199a‐3p are significantly decreased in carotid and aortic samples from patients and mice with atherosclerosis. In addition, we found an increased expression in targets of both miRNAs that participate in the inflammatory pathway of nuclear factor kappa B (NF‐κB), such as IKKα, IKKβ and p65. In human vein endothelial cells (HUVECs) and vascular smooth muscle cells (VSMCs), the overexpression of miR‐15a‐5p or miR‐199a‐3p decreased IKKα, IKKβ and p65 protein levels as well as NF‐κB activation. On the other hand, miR‐15a‐5p and miR‐199a‐3p overexpression reduced ox‐LDL uptake and the inflammation regulated by NF‐κB in VSMCs. Moreover, although miR‐15a‐5p and miR‐199a‐3p were significantly increased in exosomes from patients with advanced carotid atherosclerosis, only in the ROC analyses for miR‐15a‐5p, the area under the curve was 0.8951 with a p value of .0028.ConclusionsOur results suggest that the decrease of miR‐199a‐3p and miR‐15a‐5p in vascular samples from human and experimental atherosclerosis could be involved in the NF‐κB activation pathway, as well as in ox‐LDL uptake by VSMCs, contributing to inflammation and progression atherosclerosis. Finally, miR‐15a‐5p could be used as a novel diagnostic biomarker for advanced atherosclerosis.
Feedback levels and their interaction with the mathematical reasoning process
Authors: Smit Robbert , Bachmann Patricia , Dober Heidi , Hess Kurt 
Published: August 2023

AbstractIn our multi‐method study, feedback levels derived from the well‐known feedback model of Hattie and Timperley were used in conjunction with feedback that was related to subject‐specific content; here, mathematical reasoning tasks in primary school. Feedback needs to be aligned with the learning process; in the beginning, more task feedback is valuable. Based on the analyses of videos and questionnaires of 44 teachers of 5th‐ and 6th‐grade primary school classes (N = 804), we demonstrated that feedback for finding an approach and operationalisation were related to feedback on the task. We further showed that feedback at the task level predicted students' achievement in mathematical reasoning via students' interest in mathematics. It might be concluded that the four levels of feedback should be applied by teachers in such a way that they focus on the current problem that is occurring while the student is solving a task.
HLA DQ protein changes the cell surface distribution pattern of HLA proteins as monitored by Förster resonance energy transfer and high‐resolution electron microscopy
Authors: Kormos József , Veres Adrienn J. , Imre László , Mátyus László , Benkő Szilvia , Szöllősi János , Jenei Attila 
Published: August 2023

AbstractPeptide presentation by MHC class I and MHC class II molecules plays important roles in the regulation of the immune response. One factor in these displays is the density of antigen, which must exceed a critical threshold for the effective activation of T cells. Nonrandom distribution of MHC class I and class II has already been detected at the nanometer level and at higher hierarchical levels. It is not clear how the absence and reappearance of some protein molecules can influence the nonrandom distribution. Therefore, we performed experiments on HLA II‐deficient bare lymphocyte syndrome (BLS1) cells: we created a stable transfected cell line, tDQ6‐BLS‐1, and were able to detect the effect of the appearance of HLA‐DQ6 molecules on the homo and heteroassociation of different cell surface molecules by comparing Förster resonance energy transfer (FRET) efficiency on transfected cells to that on nontransfected BLS‐1 and JY human B‐cell lines. Our FRET results show a decrease in homoassociation FRET between HLA I chains in HLA‐DQ6‐transfected tDQ6‐BLS‐1 cells compared with the parent BLS‐1 cell line and an increase in heteroassociation FRET between HLA I and HLA II (compared with JY cells), suggesting a similar pattern of antigen presentation by the HLA‐DQ6 allele. Transmission electron microscopy (TEM) revealed that both HLA class I and class II molecules formed clusters at higher hierarchical levels on the tDQ6‐BLS‐1 cells, and the de novo synthesized HLA DQ molecules did not intersperse with HLA class I islands. These observations could be important in understanding the fine tuning of the immune response.
Ghost introgression facilitates genomic divergence of a sympatric cryptic lineage in Cycas revoluta
Authors: Chang Jui‐Tse , Nakamura Koh , Chao Chien‐Ti , Luo Min‐Xin , Liao Pei‐Chun 
Published: August 2023

AbstractA cryptic lineage is a genetically diverged but morphologically unrecognized variant of a known species. Clarifying cryptic lineage evolution is essential for quantifying species diversity. In sympatric cryptic lineage divergence compared with allopatric divergence, the forces of divergent selection and mating patterns override geographical isolation. Introgression, by supplying preadapted or neutral standing genetic variations, can promote sympatric cryptic lineage divergence via selection. However, most studies concentrated on extant species introgression, ignoring the genetic legacy of introgression from extinct or unsampled lineages (“ghost introgression”). Cycads are an ideal plant for studying the influence of ghost introgression because of their common interspecific gene flow and past high extinction rate. Here, we utilized reference‐based ddRADseq to clarify the role of ghost introgression in the evolution of a previously identified sympatric cryptic lineage in Cycas revoluta. After re‐evaluating the evolutionary independency of cryptic lineages, the group‐wise diverged single‐nucleotide polymorphisms among sympatric and allopatric lineages were compared and functionally annotated. Next, we employed an approximate Bayesian computation method for hypothesis testing to clarify the cryptic lineage evolution and ghost introgression effect. SNPs with the genomic signatures of ghost introgression were further annotated. Our results reconfirmed the evolutionary independency of cryptic lineage among C. revoluta and demonstrated that ghost introgression to the noncryptic lineage facilitated their divergence. Gene function related to heat stress and disease resistance implied ecological adaptation of the main extant populations of C. revoluta.