bluuebunny/crossref_metadata_2025_split huggingface dataset:
A greener Loess Plateau in the future: moderate warming will expand the potential distribution areas of woody species
Authors: Guo Yanlong , Zhao Zefang , Yuan Shiwei , Li Xin 
Published: February 2023

Abstract
Understanding the effect of future global warming on the distribution and diversity of woody species in the Loess Plateau is critical to the vegetation restoration and rebuilding of this area and yet is highly challenging. In the absence of enough experimental data, projection based on species distribution models is the best option for assessing the future shift in species distribution areas. Here, via a comprehensive habitat suitability model, we present an assessment of potential distribution area change for two plant life forms with a total of 42 key woody species, including 21 tree species and 21 shrub species, on the Loess Plateau under multiple scenarios, and based on this information, we explore the responses of regional potential woody species diversity to future global warming. The results showed that moderate warming will promote the expansion of potential distribution areas for most woody species and generally increase regional species diversity, which will result in a greener Loess Plateau. Our results also show that shrub species are more drought-tolerant and less adversely affected by climate change and thus should be considered a priority in vegetation restoration, especially in the arid area of the northern Loess Plateau. These results are helpful for identifying priority restoration areas, selecting appropriate species for artificial planting, and providing useful information for vegetation restoration and management in the future.
Evaluating the performance of static mixers using the

M

-number: the case of the Koflo® mixer
Authors: Medina Hector , Anthony Joby M , Eldredge Thomas 
Published: February 2023

Abstract
Static mixers (SMs) are widely used in applications that involve chemical reactions, heat transfer, blending of fluids, or some combination of these. Accurately evaluating the performance of SMs is critical for the appropriate selection of these devices. Traditional approaches involve parameters that separately evaluate the mixing level and the energy spent in mixing (i.e., pressure drop) but do not account for both simultaneously. The

M

-number has been recently proposed as a means to simultaneously evaluate the quality of mixing as well as the pressure drop across the static mixer (SM). This work demonstrates an implementation of the

M

-number by evaluating the performance of a KOFLO® static mixer (KSM) for mixing water vapor and air via Computational Fluid Dynamics (CFD), for Schmidt number of approximately unity. Pipe and mixer sizes as well as inlet profile distribution were varied. A single-element KSM was used based on the impetus of our study: Selective Catalytic Reactor (SCR) applications, which requires minimization of the pressure drop. The results are shown to be reasonably comparable with respect to previous works containing experimental data.
The Impact of the Pathologist in Multidisciplinary Cancer Conferences on Patient Care : Evidence From the Literature
Authors: Plotkin Anna , Olkhov-Mitsel Ekaterina , Gagliardi Anna R 
Published: February 2023

AbstractObjectivesMultidisciplinary cancer conferences (MCCs) are important tools in the treatment of patients with complex health issues, helping clinicians achieve optimal outcomes in oncological practice. To explore the role of pathologists at MCCs, we conducted a review of prior research on this topic.MethodsWe conducted a scoping review by searching MEDLINE, EMBASE, and the Cochrane Library for English-language qualitative, quantitative, or multiple/mixed methods studies on the role and impact of pathologists on MCCs. We used Microsoft Excel to extract data.ResultsOf 76 research results, we included only 3 studies that involved review of cancer cases by pathologists for MCCs. All 3 studies showed that expert pathology review improved the accuracy of diagnosis and refined disease staging, leading to changes in the management of melanoma, breast cancer, and gynecologic cancer. No studies explored the barriers to pathologists participating in MCCs or the strategies or interventions employed to promote or support pathologist involvement.ConclusionsWe identified a paucity of studies on the role of pathologists in MCCs. Given the positive impact of MCCs involving pathologists on the accuracy of diagnosis and optimization of treatment, future research is warranted to further establish the role and impact of pathologists in MCCs and how to promote or support pathologists’ involvement.
Can an inexpensive light-emitting diode loupe magnification device be as good as an expensive dermatoscope?
Authors: Lun Andie I , Soriano Livia , Parmar Sanjay , Sahota Anshoo 
Published: February 2023

Abstract

Background
Dermoscopy is an invaluable technique used in both primary and secondary care to provide clinical information for diagnosis of skin disorders. Access to dermatoscopes is limited because of their high cost that limits clinicians at early levels of training, as well as those in low-resource settings, from developing the essential skills of dermoscopy. Previous solutions that have been proposed to address this issue have failed to demonstrate sufficient evidence for their use as an alternative compared with the gold standard of a dermatoscope, making it difficult to justify adoption of such solutions.

Aim
To assess the noninferiority of an inexpensive light-emitting diode (LED) loupe magnification device compared with a nonpolarized dermatoscope.

Method
This study looked at 100 paired photographs of lesions taken with both devices and asked 26 clinicians to categorize the lesions.

Results
Considering the consistency of the responses, this study confirmed noninferiority of the inexpensive LED loupe magnification device. Our results showed that the LED loupe magnification device is noninferior within a 25% margin and performs 82% as well as a nonpolarized dermatoscope.

Conclusion
Our findings encourage the implementation of use of the cheaper LED loupe magnification device both in the early stages of medical training and in settings where expensive dermatoscopes are not available.
Inactivated whole-virion SARS-CoV-2 vaccines and long-term clinical outcomes in patients with coronary atherosclerosis disease in China: a prospective cohort study
Authors: Xu Huajie , Zheng Jiaojiao , Zhao Xin , Zhou Qi , Fan Bing , Wu Hongyi , Zhang Si , Ge Junbo 
Published: February 2023

Abstract

Aims
Publicized adverse events after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised concern among patients with coronary atherosclerosis disease (CAD). We sought to study the association between SARS-CoV-2 vaccines and long-term clinical outcomes including ischaemic and bleeding events among patients with CAD.

Methods and results
Inpatients diagnosed with CAD by coronary angiography, without a history of SARS-CoV-2 infection and vaccination, were included between 1 January and 30 April 2021, and underwent follow-up until 31 January 2022. Two doses of inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac, BBIBPCorV, or WIBP-CorV) were available after discharge, and the group was stratified by vaccination. The primary composite outcomes were cardiovascular death, non-fatal myocardial infarction, stent thrombosis, unplanned revascularization, ischaemic stroke, venous thrombo-embolism, or peripheral arterial thrombosis. The bleeding outcomes were Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding. Cox regression models with vaccination status as a time-dependent covariate were used to calculate the hazard ratio (HR) for the outcomes. A propensity score matching method was used to reduce confounding biases. This prospective cohort study included 2078 individuals with CAD, 1021 (49.1%) were vaccinated. During a median follow-up of 9.1 months, 45 (4.3%) primary composite outcomes occurred in the unvaccinated group, and 33 (3.2%) in the vaccinated group. In Cox regression, the adjusted HR was 1.13 [95% confidence interval (CI) 0.65–1.93]. The adjusted HR for the bleeding outcomes associated with vaccination was 0.81 [95% CI 0.35–1.19]. After matching, the adjusted HR for the primary composite outcomes associated with vaccination was 1.06 [95% CI 0.57–1.99] and for the bleeding outcomes was 0.91 [95% CI 0.35–2.38]. Similar results were found in the seven prespecified subgroups. No grade 3 adverse reactions after vaccination were recorded.

Conclusion
Our results indicated no evidence of an increased ischaemic or bleeding risk after vaccination with inactivated SARS-CoV-2 vaccine among Chinese patients with CAD, with limited statistical power.
Isolated left ventricular apical hypoplasia: case report
Authors: Román Ricardo , Anchante Henry , Menacho Katia , Medina Félix 
Published: February 2023

AbstractBackgroundIsolated left ventricular apical hypoplasia (ILVAH) is a rare, probably congenital, cardiac condition recently reported in the last two decades. Although most cases are asymptomatic or mildly symptomatic, some severe and fatal cases have been reported, leading to more efforts for appropriate diagnosis and treatment. We describe the first, and severe, case of this pathology in Peru and Latin America.Case summaryA 24-year-old male with a history of long-standing alcohol and illicit drug use presented with symptoms of heart failure (HF) and atrial fibrillation (AF). Transthoracic echocardiography showed biventricular dysfunction along with spherical left ventricle, abnormal papillary muscles’ origin from the left ventricular apex, and an elongated right ventricle wrapping around the deficient left ventricular apex. Cardiac magnetic resonance confirmed these findings and revealed subepicardial fatty replacement at the left ventricular apex. The diagnosis of ILVAH was made. He was discharged from hospital with carvedilol, enalapril, digoxin, and warfarin. Eighteen months later he remains mildly symptomatic at New York Heart Association functional class II without worsening HF nor thrombo-embolism.DiscussionThis case highlights the usefulness of multimodality non-invasive cardiovascular imaging for accurate diagnosis of ILVAH as well as the importance of close follow-up and treatment of established complications (HF and AF).
Cardiac sarcoidosis in a carrier of transthyretin gene mutation: a case report
Authors: Menale Silvia , Scheggi Valentina , Vanni Francesco , Di Mario Carlo 
Published: February 2023

AbstractBackgroundSarcoidosis is a rare multiorgan inflammatory disorder of unknown aetiology, characterized by the formation of non-caseating granulomas in the affected organs. Cardiac involvement is underrecognized and observed in up to 25% of cases in autopsy studies, and is associated with a high mortality rate, especially due to sudden cardiac death due to ventricular arrhythmias.Case summaryA 41-year-old man well known to our hospital because of his father’s diagnosis of cardiac amyloidosis, and carrier of transthyretin (TTR) gene mutation, was hospitalized following a resuscitated cardiac arrest. The patient was hospitalized a month before for a syncopal episode with demonstration of preserved left ventricular ejection fraction (LVEF) with akinetic basal septum at heart ultrasound and normal coronary. Chest computed tomography, performed in the emergency department, was significant for hilar lymphadenopathies and pulmonary nodules highly suggestive of sarcoidosis. A subsequent 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed multiorgan phlogistic involvement, including the myocardium. After the diagnosis of cardiac sarcoidosis, the patient was started on steroids therapy and underwent ICD implantation. A follow-up 18-FDG-PET showed a reduction of organs glucose uptake and a follow-up echo an improvement in LVEF. Despite that, he occurs occasional recording of repetitive ventricular arrhythmias and one appropriate ICD shock during the next 12 months.DiscussionCardiac sarcoidosis is an insidious disease. Its diagnosis can be challenging, with no specific finding in echocardiography. The best strategy would be multi-modality imaging involving both magnetic resonance imaging with late gadolinium enhancement and 18-FDG-PET, followed by biopsy to confirm the diagnosis. Multi-modality imaging should be further used to evaluate the response to treatment and assess prognosis. Since the patient was a known carrier of the TTR gene mutation, many efforts were made in order to come up with the correct diagnosis considering that both cardiac amyloidosis and cardiac sarcoidosis are non-ischaemic cardiomyopathy with systemic involvement.
The association of electronic health literacy with behavioural and psychological coronary artery disease risk factors in patients after percutaneous coronary intervention: a 12-month follow-up study
Authors: Brørs Gunhild , Dalen Håvard , Allore Heather , Deaton Christi , Fridlund Bengt , Norman Cameron D , Palm Pernille , Wentzel-Larsen Tore , Norekvål Tone M 
Published: February 2023

Abstract

Aims
Fundamental roadblocks, such as non-use and low electronic health (eHealth) literacy, prevent the implementation of eHealth resources. The aims were to study internet usage for health information and eHealth literacy in patients after percutaneous coronary intervention (PCI). Further, we aimed to evaluate temporal changes and determine whether the use of the internet to find health information and eHealth literacy were associated with coronary artery disease (CAD) risk factors at the index admission and 12-month follow-up of the same population.

Methods and results
This prospective longitudinal study recruited 2924 adult patients with internet access treated by PCI in two Nordic countries. Assessments were made at baseline and 12-month follow-up, including a de novo question Have you used the internet to find information about health?, the eHealth literacy scale, and assessment of clinical, behavioural, and psychological CAD risk factors. Regression analyses were used. Patients’ use of the internet for health information and their eHealth literacy were moderate at baseline but significantly lower at 12-month follow-up. Non-users of the internet for health information were more often smokers and had a lower burden of anxiety symptoms. Lower eHealth literacy was associated with a higher burden of depression symptoms at baseline and lower physical activity and being a smoker at baseline and at 12-month follow-up.

Conclusion
Non-use of the internet and lower eHealth literacy need to be considered when implementing eHealth resources, as they are associated with behavioural and psychological CAD risk factors. eHealth should therefore be designed and implemented with high-risk CAD patients in mind.

Clinical trial registration
ClinicalTrials.gov NCT03810612 https://clinicaltrials.gov/ct2/show/NCT03810612
Real world evidence: Perspectives from a European Society of Cardiology Cardiovascular Round Table with contribution from the European Medicines Agency
Authors: Szymański Piotr , Weidinger Franz , Lordereau-Richard Isabelle , Himmelmann Anders , Arca Marcello , Chaves Jose , Lee Charles , Jonker Carla , Kotecha Dipak , O'Kelly James , Plueschke Kelly , Ryś Andrzej , Segec Andrej , Wallentin Lars , Veltrop Rogier , James Stefan 
Published: February 2023

AbstractReal world data (RWD) refers to healthcare information that is routinely collected in electronic healthcare records (EHR), hospital and pharmacy records, patient and disease registries, and health insurance databases. The collection and analysis of this vast amount of data is an important complement to that obtained from conventional randomised controlled trials (RCT). Real world data has been used for healthcare quality improvements, to conduct clinical trials, to support drug and device development, and to inform medical guidelines. The utility of RWD may be facilitated by common data models, which standardise format and content, and allow data from different health systems to be analysed together.The European Society of Cardiology (ESC) supports the use of RWD in collaboration with national cardiac societies, regulatory authorities, and industry to encourage continuous quality of care improvements at the hospital and country level, to conduct registry-based randomised clinical trials (R-RCT) and to facilitate safety surveillance of novel drugs and devices.The European Medicines Agency (EMA) is developing systems and processes to enable the use of RWD that can help in trial planning, defining clinical contexts, and enhancing outcome assessments. RWD can also contribute to the measurement of the impact of regulatory actions, such as contraindications or restriction of indications by looking at medicines use patterns over time across European Member States. A number of other initiatives from the European Commission and the EMA are underway to strengthen the EU's health security framework, and foster the collection and utilisation of RWD.
French national addictovigilance follow-up of zolpidem between 2014 and 2020: evolution of drug abuse, misuse and dependence before and after the regulatory change
Authors: Aquizerate Aurélie , Laforgue Edouard-Jules , Istvan Marion , Rousselet Morgane , Gerardin Marie , Jouanjus Emilie , Libert Frédéric ,   French Addictovigilance Network, Caous Anne-Sylvie , Chaouachi Leila , Chevallier Cécile , Daveluy Amélie , Eiden Céline , Fauconneau Bernard , Fournier-Choma Christine , Gibaja Valérie , Lacroix Clémence , Lapeyre-Mestre Maryse , Le Boisselier Reynald , Revol Bruno , Guerlais Marylène , Victorri-Vigneau Caroline 
Published: February 2023

AbstractBackgroundSince the appearance of zolpidem on the market, the occurrence of serious cases of abuse, misuse and dependence have come to the attention of authorities. In view of the increase in the number and severity of cases among zolpidem users and the predominant presence of zolpidem in falsified prescriptions, the French Health Authorities implemented part of the narcotics regulation for zolpidem in April 2017. The objective of this article was to describe the evolution of the abuse, dependence and misuse of zolpidem.MethodsWe used three data sources: (i) zolpidem is a reimbursable and strictly prescription drug in France. Medic’AM is a public database that indicates the number of tablets reimbursed each month in France for each reimbursable drug. This database has been analyzed as a proxy of the exposure of the French population to zolpidem; (ii) all French cases of drug dependence or abuse reported by health professionals (regulatory obligation) and (iii) an epidemiological tool based on the surveillance of falsified prescriptions over two periods: the 3-year period before the regulatory measure (2014–16) and the 3-year period after the regulatory measure (2018–20).ResultsThis regulatory change had two immediate consequences: a sharp decline in falsified prescriptions and a decrease of ∼57% between the two study periods in the zolpidem reimbursement data. Markers of problematic consumption remained after the regulatory change with worsening cases, particularly for people who were genuinely dependent and/or had comorbidities or misusers for whom zolpidem was the substance of interest, whose proportion increased significantly in the addictovigilance notification system, from 43.6% (N = 107) to 59.3% (N = 127) (P &lt; 0.01).ConclusionsFurther monitoring is needed in light of these persistent markers of problematic consumption.
Effect-directed analysis and beyond: how to find causal environmental toxicants
Authors: Tian Zhenyu , McMinn Madison H , Fang Mingliang 
Published: February 2023

AbstractHumans and wildlife are exposed to complex environmental mixtures. Identifying causal toxic pollutants in environmental samples remains challenging because of the high complexity of sample mixtures and the unknown nature of the potential toxicants. In the field of environmental chemistry and toxicology, this pursuit of causal toxicants leads us to the method of effect-directed analysis (EDA), an integrated method comprised of three iterative modules: (1) bioassays to guide component prioritization; (2) fractionation to reduce the mixture complexity; and (3) chemical analysis to identify the toxicants. In this commentary review, we try to provide a concise guideline for EDA beginners by summarizing good practices from successful EDA studies, categorized by sample-toxicity pair selection, efficient separation, and chemical analysis. We also discussed the practical challenges faced with current EDA practices. Based on these above, we try to provide suggestions and perspectives for future EDA studies. Specifically, we discussed the potential of applying EDA on human biological examples to identify the environmental causes of human diseases. We proposed future collaboration between environmental chemists and toxicologists, environmental health scientists, epidemiologists, physicians, and social scientists.
Experimental considerations for study of C. elegans lysosomal proteins
Authors: Clancy John C , Vo An A , Myles Krista M , Levenson Max T , Ragle James Matthew , Ward Jordan D 
Published: February 2023

Abstract
Lysosomes are an important organelle required for the degradation of a range of cellular components. Lysosome function is critical for development and homeostasis as dysfunction can lead to inherited genetic disorders, cancer, and neurodegenerative and metabolic diseases. The acidic and protease-rich environment of lysosomes poses experimental challenges. Many fluorescent proteins are quenched or degraded, while specific red fluorescent proteins can be cleaved from translational fusion partners and accumulate. While studying MLT-11, a Caenorhabditis elegans molting factor that localizes to lysosomes and the cuticle, we sought to optimize several experimental parameters. We found that, in contrast to mNeonGreen fusions, mScarlet fusions to MLT-11 missed cuticular and rectal epithelial localization. Rapid sample lysis and denaturation were critical for preventing MLT-11 fragmentation while preparing lysates for western blots. Using a model lysosomal substrate (NUC-1), we found that rigid polyproline linkers and truncated mCherry constructs do not prevent cleavage of mCherry from NUC-1. We provide evidence that extended localization in lysosomal environments prevents the detection of FLAG epitopes in western blots. Finally, we optimize an acid-tolerant green fluorescent protein (Gamillus) for use in C. elegans. These experiments provide important experimental considerations and new reagents for the study of C. elegans lysosomal proteins.