bluuebunny/crossref_metadata_2025_split huggingface dataset:
An improved distributed secondary control for multi‐voltage‐level DC distribution networks with virtual impedance arrangement
Authors: Hu Daner , Peng Yonggang , Wan Keting , Wang Xiaoming , Wei Wei 
Published: February 2023

AbstractThe distributed secondary control of the DC distribution network is becoming increasingly important in modern power systems to achieve accurate power sharing of each distributed unit. Here, an improved secondary control strategy for energy storage systems (ESSs) in the multi‐voltage‐level DC distribution network (MVL‐DCDN) is proposed. At the primary control level, the interlinked DC transformers (DCT) are controlled by difference‐of‐v2 to support bidirectional voltage making the MVL‐DCDN regarded as a single‐voltage‐level one using only the local information of DCT. At the secondary control level, it can be observed that the voltage correction term and virtual impedance correction term have a coupling relationship. In order to tackle this coupling effect, a distributed secondary control is imposed in an MVL‐DCDN based on improved droop control. Concretely, this proposed secondary control strategy contains a power sharing controller, a virtual impedance controller, an average voltage restoration controller, and a reference voltage consensus controller. With the proposed method, this coupling effect can be eliminated to ensure the steady operation of the virtual impedance. Furthermore, a steady‐state analysis is performed to discuss the unique solution of the DC distribution network and conduct hardware‐in‐loop experiments to demonstrate that this method achieves effective results.
KMT-2021-BLG-1122L: The first microlensing triple stellar system
Authors: Han Cheongho , Jung Youn Kil , Gould Andrew , Kim Doeon , Lee Chung-Uk , Albrow Michael D. , Chung Sun-Ju , Hwang Kyu-Ha , Kim Hyoun-Woo , Ryu Yoon-Hyun , Shin In-Gu , Shvartzvald Yossi , Yang Hongjing , Yee Jennifer C. , Zang Weicheng , Cha Sang-Mok , Kim Dong-Jin , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. 
Published: February 2023

Aims. We systematically inspected the microlensing data acquired by the KMTNet survey during the previous seasons in order to find anomalous lensing events for which the anomalies in the lensing light curves cannot be explained by the usual binary-lens or binary-source interpretations.
Methods. From the inspection, we find that interpreting the three lensing events OGLE-2018-BLG-0584, KMT-2018-BLG-2119, and KMT-2021-BLG-1122 requires four-body (lens+source) models, in which either both the lens and source are binaries (2L2S event) or the lens is a triple system (3L1S event). Following the analyses of the 2L2S events presented in our previous work, here we present the 3L1S analysis of the KMT-2021-BLG-1122.
Results. It is found that the lens of the event KMT-2021-BLG-1122 is composed of three masses, in which the projected separations (normalized to the angular Einstein radius) and mass ratios between the lens companions and the primary are (s2, q2)∼(1.4, 0.53) and (s3, q3)∼(1.6, 0.24). By conducting a Bayesian analysis, we estimate that the masses of the individual lens components are (M1, M2, M3)∼(0.47 M⊙, 0.24 M⊙, 0.11 M⊙). The companions are separated in projection from the primary by (a⊥, 2, a⊥, 3)∼(3.5, 4.0) AU. The lens of KMT-2018-BLG-2119 is the first triple stellar system detected via microlensing.
Intersektorales Management von Patienten mit unklarer Leberwerterhöhung und nichtalkoholischer Fettlebererkrankung (NAFLD)
Authors: Teufel Andreas , Geier Andreas , Sarrazin Christoph , Schattenberg Jörn M. , Kautz Achim , Dorner Rebecca , Kramer Jan , Jerysiak Katrin , Baars Theodor , Hönscheid Bastian , Müller-Wieland Dirk , Rossol Siegbert , Trautwein Christian , Tacke Frank , Canbay Ali 
Published: February 2023

Zusammenfassung
Die Prävalenz der Fettlebererkrankung hat in den letzten Jahren auch in Deutschland
erheblich zugenommen. Sie gehört mit geschätzten 18 Mio. betroffenen Bundesbürgern
mittlerweile zu den großen Volkskrankheiten. Sie gilt ferner als ein relevanter unabhängiger
Risikofaktor für weitere kardiovaskuläre Volkskrankheiten wie Herzinfarkt oder Schlaganfall.
Schließlich begünstigt ein Diabetes mellitus die Entstehung einer Fettleber und eines
ungünstigeren Verlaufs der Fettlebererkrankung. Vor dem Hintergrund der hohen Prävalenz und
Komplikationen kommt das deutsche Gesundheitssystem bei der Versorgung dieser Patienten an die
Grenzen seiner Ressourcen.Daher ist eine enge Abstimmung und Vernetzung aller an der Behandlung dieser Patienten
beteiligten Fachgebiete und Versorgungsbereiche essenziell notwendig. In einem
Expertenkonsensus unter Einbindung niedergelassener Kollegen und Krankenhausärzten der
Gastroenterologie, Endokrinologie, Kardiologie, Hausärzten und Labormedizinern sowie in enger
Abstimmung mit Patientenvertretern haben wir ein Konzept der Versorgung dieser Patienten im
deutschen Gesundheitssystem entworfen. Darin werden auch notwendige Entwicklungen adressiert.
Neben dem Nutzen als praxisnahem Leitfaden soll dies auch die gesundheitspolitische Arbeit
unterstützen, insbesondere bei der Erarbeitung von praktischen Versorgungslösungen auf
medizinischer Ebene.
Es braucht Mut, um die Zukunft der Perinatologie gemeinsam zu gestalten
Authors: Schleußner Ekkehard 
Published: February 2023

Liebe Kolleginnen und KollegenMenschen demonstrieren vor
Krankenhäusern oder dem Landtag in Hessen, Mecklenburg-Vorpommern oder
Thüringen für den Erhalt ihrer Geburtsklinik vor Ort. Petitionen
werden an die Bundes- und Landesministerien für Gesundheit geschickt, dass
ihr Perinatalzentrum Level I nicht durch die Mindestmengen ab 2023/24
betroffen sein darf…
Providing Online Portal Access to Families of Adolescents and Young Adults with Diminished Capacity at an Academic Children's Hospital: A Case Report
Authors: Carlson Jennifer L. , Pageler Natalie , McPherson Tom , Anoshiravani Arash 
Published: February 2023

Abstract
Background For caregivers of adolescents and young adults with severe cognitive deficits, or “diminished capacity,” access to the medical record can be critical. However, this can be a challenge when utilizing the electronic health record (EHR) as information is often restricted in order to protect adolescent confidentiality. Having enhanced access for these proxies would be expected to improve engagement with the health system for the families of these medically complex adolescents and young adults.
Objectives To describe a process for granting full EHR access to proxies of adolescents with diminished capacity and young adults who are legally conserved while respecting regulations supporting adolescent confidentiality.
Methods The first step in this initiative was to define the “diminished capacity” access class for both adolescents and young adults. Once defined, workflows utilizing best practice alerts were developed to support clinicians in providing the appropriate documentation. In addition, processes were developed to minimize the possibility of erroneously activating the diminished capacity access class for any given patient. To enhance activation, a support tool was developed to identify patients who might meet the criteria for diminished capacity proxy access. Finally, outreach and educations were developed for providers and clinics to make them aware of this initiative.
Results Since activating this workflow, proxies of 138 adolescents and young adults have been granted the diminished capacity proxy access class. Approximately 54% are between 12 and 17 years with 46% 18 years and older. Proxies for both age groups have engaged with portal functionality at higher rates when compared to institutional rates of use by proxies of the general pediatric population.
Conclusion With this quality improvement initiative, we were able to enhance EHR access and engagement of families of some of the most complex adolescent and young adult patients without inadvertently compromising adolescent confidentiality.
Is government spending in the education and health sector necessary for human capital development?
Authors: Kousar Shazia , Ahmed Farhan , Afzal Muhammad , Segovia Juan E. Trinidad 
Published: February 2023

AbstractThis study intends to examine the impact of current health expenditure, domestic government health expenditure, government education expenditure, social protection, population growth, and foreign direct investment (FDI) on human capital formation in the context of Pakistan. This study utilized skill and health to measure human capital. The study utilized annual data for the period of 1990–2020 and data has been extracted from World Development Indicators (WDI) and World Bank. The study utilized auto-regressive distributed lag (ARDL) bound test to examine long-run co-integration among defined variables. Furthermore, the study employed ARDL Model to obtain long-run and short-run empirical estimates for modeled variables. The results of this study indicated that current health expenditure (CHE), domestic government health expenditure (DGHE), government education expenditures (GEE), foreign direct expenditure (FDI), and social protection program (SP) have a positive and significant association with human capital in term of primary, secondary, and tertiary education attainment and life expectancy at birth. Moreover, domestic government spending on health and education, and social protection program significantly decreases child mortality in Pakistan. Furthermore, this study found that population growth has a negative and significant association with primary attainment. The findings of this study suggest that the Government of Pakistan should allocate more of its budget for health, education, and social protection programs to uplift its human capital.
The role of symmetric vibrational modes in the decoherence of correlation-driven charge migration
Authors: Vester J. , Despré V. , Kuleff A. I. 
Published: February 2023

Due to the electron correlation, the fast removal of an electron from a molecule may create a coherent superposition of cationic states and in this way initiate pure electronic dynamics in which the hole-charge left by the ionization migrates throughout the system on an ultrashort time scale. The coupling to the nuclear motion introduces a decoherence that eventually traps the charge, and crucial questions in the field of attochemistry include how long the electronic coherence lasts and which nuclear degrees of freedom are mostly responsible for the decoherence. Here, we report full-dimensional quantum calculations of the concerted electron-nuclear dynamics following outer-valence ionization of propynamide, which reveal that the pure electronic coherences last only 2–3 fs before being destroyed by the nuclear motion. Our analysis shows that the normal modes that are mostly responsible for the fast electronic decoherence are the symmetric in-plane modes. All other modes have little or no effect on the charge migration. This information can be useful to guide the development of reduced dimensionality models for larger systems or the search for molecules with long coherence times.
Locally-enhanced optical properties in a hybrid organic/inorganic (coronene/MoS2) Van der Waals heterostructure
Authors: Gadelha Andreij C , Santos Joyce C C , Rabelo Cassiano , Vasconcelos Thiago L , Alencar Rafael S , Monken Vitor , Miranda Hudson L S , Cury Luiz A , Jaques Ygor M , Tromer Raphael M , Galvão Douglas S , Cançado Luiz G , Neves Bernardo R A , Jorio Ado 
Published: February 2023

Abstract
Hybrid organic/inorganic Van der Waals heterostructures have emerged recently with enormous potential applications in nanotechnology and industrial areas. In these heterostructures, the interfacial effects can modulate the final properties, creating further possibilities in the design and operation of innovative devices. With this perspective in mind, we report on an experimental investigation of a hybrid organic/inorganic heterostructure of coronene and a few-layers

MoS

2

. We observe a local enhancement of

MoS

2

optical properties using both far-field and near-field Raman scattering and photoluminescence. Mainly located at

MoS

2

edges and defects, the local enhancement is due to the assembling of coronene molecules in

MoS

2

, as confirmed by atomic force microscopy. Quantum semi-empirical and fully atomistic molecular dynamics simulations were also used to gain further insights into these phenomena. Our results pave the way to engineer molecules in two-dimensional (2D) layered nanomaterials and control and modulate optical phenomena.
Recent advances in magnetoresistance biosensors: a short review
Authors: Dey Clifton , Yari Parsa , Wu Kai 
Published: February 2023

Abstract
Recent years have seen the development of spintronic devices and their applications in biomedical areas. Spintronic devices rely on detecting or manipulating a magnetic field, a field to which biological matter is relatively transparent. The recent use of spintronic devices in biomedical areas has included diagnosing diseases such as cancer and cirrhosis, genotyping DNA, point-of-care devices, and flexible electronics. Up to date, most of the spintronic devices in biomedical applications fall into three mainstream types: anisotropic, giant, and tunneling magnetoresistance devices. Each of these has its advantages and drawbacks, which are explored and discussed in this article. The advent of spintronics gives us a new low-power, low-cost, ease-of-manufacture alternative to standard CMOS sensors. The sensitivity of spintronic biosensors has been progressing steadily, expected to increase tremendously in the next few years.
A smart alarm for particle accelerator beamline operations
Authors: Tennant Chris , Freeman Brian , Kazimi Reza , Moser Daniel , Abell Dan , Edelen Jonathan , Einstein-Curtis Joshua 
Published: February 2023

Abstract
We present the initial results of a proof-of-concept ‘smart alarm’ for the Continuous Electron Beam Accelerator Facility injector beamline at Jefferson Lab. To minimize machine downtime and improve operational efficiency, an autonomous alarm system able to identify and diagnose unusual machine states is needed. Our approach leverages a trained neural network capable of alerting operators (a) when an anomalous condition exists in the beamline and (b) identifying the element setting that is the root cause. The tool is based on an inverse model that maps beamline readings (diagnostic readbacks) to settings (beamline attributes operators can modify). The model takes as input readings from the machine and computes machine settings which are compared to control setpoints. Instances where predictions differ from setpoints by a user-defined threshold are flagged as anomalous. Given data corresponding to 354 anomalous injector configurations, the model can narrow the root cause of an anomalous condition to three potential candidates with 94.6% accuracy. Furthermore, compared to the current method of identifying anomalous conditions which raises an alarm when machine parameters drift outside their normal tolerances, the data-driven model can identify 83% more anomalous conditions.
PFresGO: an attention mechanism-based deep-learning approach for protein annotation by integrating gene ontology inter-relationships
Authors: Pan Tong , Li Chen , Bi Yue , Wang Zhikang , Gasser Robin B , Purcell Anthony W , Akutsu Tatsuya , Webb Geoffrey I , Imoto Seiya , Song Jiangning 
Published: February 2023

AbstractMotivationThe rapid accumulation of high-throughput sequence data demands the development of effective and efficient data-driven computational methods to functionally annotate proteins. However, most current approaches used for functional annotation simply focus on the use of protein-level information but ignore inter-relationships among annotations.ResultsHere, we established PFresGO, an attention-based deep-learning approach that incorporates hierarchical structures in Gene Ontology (GO) graphs and advances in natural language processing algorithms for the functional annotation of proteins. PFresGO employs a self-attention operation to capture the inter-relationships of GO terms, updates its embedding accordingly and uses a cross-attention operation to project protein representations and GO embedding into a common latent space to identify global protein sequence patterns and local functional residues. We demonstrate that PFresGO consistently achieves superior performance across GO categories when compared with ‘state-of-the-art’ methods. Importantly, we show that PFresGO can identify functionally important residues in protein sequences by assessing the distribution of attention weightings. PFresGO should serve as an effective tool for the accurate functional annotation of proteins and functional domains within proteins.Availability and implementationPFresGO is available for academic purposes at https://github.com/BioColLab/PFresGO.Supplementary informationSupplementary data are available at Bioinformatics online.
Phase IIb randomized CONTROL study demonstrates a novel topical isotretinoin formulation, TMB-001, is safe and effective in participants with either recessive X-linked or autosomal recessive lamellar congenital ichthyosis
Authors: Murrell Dedee F , Teng Joyce M C , Guenthner Scott , Marathe Kalyani , Kempers Steven , Eads Kimmie , Castelo-Soccio Leslie , Mendelsohn Alan M , Raiz Jessica , Bunick Christopher G 
Published: February 2023

Abstract

Background
In two severe congenital ichthyosis subtypes, autosomal recessive lamellar ichthyosis (ARCI-LI) and X-linked recessive ichthyosis (XLRI), cutaneous manifestations include widespread scaling. Approved topical treatment options are limited to emollients and keratolytics.

Aim
This analysis from the randomized phase IIb CONTROL study assessed whether the efficacy and safety of TMB-001, a novel topical isotretinoin ointment formulation, differed between ARCI-LI and XLRI subtypes.

Methods
Participants ≥ 9 years with genetically confirmed XLRI or ARCI-LI and ≥ 2 (of 4) Visual Index for Ichthyosis Severity (VIIS) assessment areas with ≥ 3 scaling score were randomized 1 : 1 : 1 to TMB-001 0.05%/TMB-001 0.1%/vehicle, twice daily for 12 weeks. The proportion of participants with ≥ 50% reduction vs. baseline in VIIS scaling (VIIS 50; primary endpoint) and ≥ 2-grade reduction in Investigator’s Global Assessment (IGA)-scaling score vs. baseline (key secondary endpoint) were evaluated. Adverse events (AEs) were monitored.

Results
Among enrolled participants (TMB-001 0.05%, n = 11; 0.1%, n = 10; and vehicle, n = 12), 52% had ARCI-LI and 48% XLRI subtypes. Mean age was 33.6 and 35.4 years for participants with ARCI-LI and XLRI, respectively. Overall, 33%, 50% and 17% of participants with ARCI-LI and 100%, 33% and 75% of participants with XLRI achieved VIIS 50 in the TMB-001 0.05%, TMB-001 0.1% and vehicle groups, respectively (nominal P = 0.24 for 0.05% vs. vehicle, intent-to-treat population). Improvement of ≥ 2-grade IGA score was observed in 33%, 50% and 0% of participants with ARCI-LI and 83%, 33% and 25% of participants with XLRI in the TMB-001 0.05%, TMB-001 0.1% and vehicle groups, respectively (nominal P = 0.03 for 0.05% vs. vehicle, intention-to-treat population). Most AEs were application-site reactions.

Conclusion
Regardless of congenital ichthyosis subtype, TMB-001 demonstrated greater proportions of participants achieving VIIS 50 and ≥ 2-grade IGA improvement vs. vehicle.
Kidney function changes in acute heart failure: a practical approach to interpretation and management
Authors: Kenneally Laura Fuertes , Lorenzo Miguel , Romero-González Gregorio , Cobo Marta , Núñez Gonzalo , Górriz Jose Luis , Barrios Ana Garcia , Fudim Marat , de la Espriella Rafael , Núñez Julio 
Published: February 2023

ABSTRACT
Worsening kidney function (WKF) is common in patients with acute heart failure (AHF) syndromes. Although WKF has traditionally been associated with worse outcomes on a population level, serum creatinine concentrations vary greatly during episodes of worsening heart failure, with substantial individual heterogeneity in terms of their clinical meaning. Consequently, interpreting such changes within the appropriate clinical context is essential to unravel the pathophysiology of kidney function changes and appropriately interpret their clinical meaning. This article aims to provide a critical overview of WKF in AHF, aiming to provide physicians with some tips and tricks to appropriately interpret kidney function changes in the context of AHF.
Trends in Surgical Recurrence Among Pediatric Crohn’s Disease Patients Using Administrative Claims Data
Authors: Egberg Matthew D , Zhang Xian , Phillips Michael , Kappelman Michael D 
Published: February 2023

AbstractBackgroundDespite the growing armamentarium of medical therapies for Crohn’s disease (CD), well over half of patients with CD will require surgical intervention. We estimated the surgical recurrence risk and characterized postoperative treatment and colonoscopy use in pediatric CD patients using a large, geographically diverse administrative claims database.MethodsWe analyzed postresection pediatric (≤18 years) CD patients identified in the 2007–2018 IQVIA Legacy PharMetrics administrative claims database using diagnosis and procedural codes. We estimated the surgical recurrence risk over time, characterized postoperative treatments, and reported the frequency of colonoscopy 6–15 months postoperatively.ResultsAmong 434 pediatric CD patients who underwent intestinal resection (median age 16 years, 46% female), risk of surgical recurrence was 3.5%, 4.6%, and 5.3% at 1, 3, and 5 years, respectively. Patients were most commonly prescribed an immune modulator (33%), anti-tumor necrosis factor agent (32%), or antibiotic (27%) postoperatively. Among 281 patients with ≥15 months of follow-up, 24% underwent colonoscopy 6–15 months postoperatively.ConclusionsSurgical recurrence risk increases over time and the low colonoscopy rates and treatment variation postoperatively represent an opportunity for practice improvement.
Sex differences in potential triggers of myocardial infarction
Authors: Olsson Anneli , Mohammad Moman A , Rylance Rebecca , Platonov Pyotr G , Sparv David , Erlinge David 
Published: February 2023

Abstract

Aims
Internal and external triggers affect seasonal and circadian variations of myocardial infarction (MI). We aimed to assess sex differences in the common triggers of MI.

Methods and results
A nationwide, retrospective, cross-sectional postal survey study was conducted. Individuals who experienced a MI during holidays and weekdays were identified through the SWEDEHEART registry. Twenty-seven potential MI triggers were rated in regards to occurring more or less than usual during the last 24 h before the MI. Three areas were covered: activities, emotions, and food or alcohol consumption. A logistic regression model was used to identify sex differences for each trigger and odds ratios (ORs) were reported. Four hundred and fifty-one patients, of whom 317 were men, responded. The most commonly reported triggers were stress (35.3%), worry (26.2%), depression (21.1%), and insomnia (20.0%). Women reported emotional triggers including sadness [OR 3.52, 95% confidence interval (CI) 1.92–6.45], stress (OR 2.38, 95% CI 1.52–3.71), insomnia (OR 2.31, 95% CI 1.39–3.81), and upset (OR 2.69, 95% CI 1.47–4.95) to a greater extent than men. Outdoor activity was less reported by women (OR 0.35, 95% CI 0.14–0.87). No significant sex differences were found in other activities or food and alcohol consumption.

Conclusion
Self-experienced stress and distress were higher among women prior to MI compared with men. Understanding sex perspectives in acute triggers may help us find preventive strategies and reduce the excess numbers of MI.