bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coordination and Stabilization of a Lithium Ion with a Silylene
Authors: Nazish Mohd , Legendre Christina M. , Graw Nico , Herbst‐Irmer Regine , Stalke Dietmar , Sankar Dutta Siddharth , Lourderaj Upakarasamy , Roesky Herbert W. 
Published: December 2022

AbstractHerein, we report the stabilization of lithium‐ion as the source of lithium to use as a trans‐metalation reagent [{PhC(NtBu)2Si(tBu)Li}2I(tBuN)2CPh] (1). The reaction of 3 equivalents of the LSitBu (L=PhC(NtBu)2) and lithium iodide at low temperature leads to a silylene stabilized lithium‐ion with an additional coordination of amidinate ligand. Compound 1 shows two four membered and one six membered ring as confirmed by QTAIM calculations. Whereas the reaction of the LSiCl with 1.5 equivalents of carbodiimide (CyN)2C at room temperature affords compound [PhC(NtBu)2Si(Cl)(NCy)2NCy] (2) with the CN2SiN2C skeleton containing silicon as a central atom. Both the compounds were fully characterized by NMR, mass spectrometry, X‐ray crystallographic analysis, and quantum mechanical calculations.
4‐O‐Substituted Glucuronic Cyclophellitols are Selective Mechanism‐Based Heparanase Inhibitors
Authors: Borlandelli Valentina , Armstrong Zachary , Nin‐Hill Alba , Codée Jeroen D. C. , Raich Lluís , Artola Marta , Rovira Carme , Davies Gideon J. , Overkleeft Herman S. 
Published: December 2022

AbstractDegradation of the extracellular matrix (ECM) supports tissue integrity and homeostasis, but is also a key factor in cancer metastasis. Heparanase (HPSE) is a mammalian ECM‐remodeling enzyme with β‐D‐endo‐glucuronidase activity overexpressed in several malignancies, and is thought to facilitate tumor growth and metastasis. By this virtue, HPSE is considered an attractive target for the development of cancer therapies, yet to date no HPSE inhibitors have progressed to the clinic. Here we report on the discovery of glucurono‐configured cyclitol derivatives featuring simple substituents at the 4‐O‐position as irreversible HPSE inhibitors. We show that these compounds, unlike glucurono‐cyclophellitol, are selective for HPSE over β‐D‐exo‐glucuronidase (GUSB), also in platelet lysate. The observed selectivity is induced by steric and electrostatic interactions of the substituents at the 4‐O‐position. Crystallographic analysis supports this rationale for HPSE selectivity, and computer simulations provide insights in the conformational preferences and binding poses of the inhibitors, which we believe are good starting points for the future development of HPSE‐targeting antimetastatic cancer drugs.
Reasons for refusal of the human papillomavirus vaccine among young cancer survivors
Authors: Cherven Brooke , Klosky James L. , Keith K. Elizabeth , Hudson Melissa M. , Bhatia Smita , Landier Wendy 
Published: December 2022

AbstractBackgroundCancer survivors are at risk for developing subsequent human papillomavirus (HPV)–related malignancies. HPV vaccination rates among survivors remain low, and the reasons for refusal of the vaccine are unclear in this population.MethodsThe authors conducted a secondary analysis of data from an open‐label clinical trial evaluating the immunogenicity and safety of the HPV vaccine among vaccine‐naive cancer survivors who were 9–26 years old and 1–5 years from the completion of their cancer treatment. Survivors/parents who declined trial participation were asked their reasons for declining. Refusal reasons were categorized, and multivariable logistic regression models were developed to identify associations between survivor characteristics and primary refusal reasons.ResultsAmong the 301 survivors who refused participation in the clinical trial, 215 (71.4%) refused for reasons related to the HPV vaccine. Reasons for vaccine‐related refusal included safety concerns, vaccine hesitancy/disinterest, external influences, vaccine‐related information deficits, and health beliefs/family decisional processes. Compared with males, females were more likely to refuse for reasons related to health beliefs/family decisional processes (odds ratio [OR], 2.08; 95% confidence interval [CI], 1.12–3.93; p = .022) and were less likely to do so because of external influences (OR, 0.43; 95% CI, 0.19–0.92; p = .035). Survivors approached about participation during the latter years of the trial were more likely to refuse because of safety concerns (OR, 3.33; 95% CI, 1.55–7.69; p = .003).ConclusionsCancer survivors refused participation in an open‐label trial evaluating the immunogenicity and safety of the HPV vaccine primarily because of vaccine‐related concerns that were unrelated to the research study. Many of these concerns are potentially addressable by health care providers using evidence‐based messages tailored to the cancer survivor population.
Anti‐cancer effect of entacaponeon esophageal cancer cells via apoptosis induction and cell cycle modulation
Authors: Ramedani Fahimeh , Jafari Seyyed Mehdi , Saghaeian Jazi Marie , Mohammadi Zeinab , Asadi Jahanbakhsh 
Published: December 2022

AbstractBackgroundEsophageal cancer (EC) is the sixth leading cause of cancer‐related death, despite many advances in treatment, the survival of patients still remains poor. In recent years, the N6‐methyladenosine (m6A) has been introduced as one of the most important modifications at the epitranscriptome level, with an important role in the mRNA regulation in various diseases, such as cancers. The m6A is regulated by different factors, including FTO as a demethylase. The m6A modification, especially through FTO overexpression has an oncogenic role in different cancer types such as EC. Recent studies showed that entacapone, a catechol‐o‐methyl transferase (COMT) inhibitor currently applied for Parkinson's disease, can inhibit FTO enzyme.AimsIn this study, we aimed to investigate the effect of entacapone as an FTO inhibitor on the m6A level and also apoptosis and cell cycle response in KYSE‐30 and YM‐1 of esophageal squamous cancer cell (ESCC) lines.MethodsCell toxicity and IC50 of entacapone were evaluated using The MTT assay in YM‐1 and KYSE‐30 cells. Cells were treated into two groups: DMSO (control) and entacapone (mean IC50). Total RNA was extracted, and m6A levels were measured via the ELISA method. Subsequently, the apoptosis and cell cycle dys‐regulation were detected by annexin‐V‐FITC/PI staining and PI staining via flow cytometry.ResultsEntacapone has the cytotoxicity effect on both esophageal cancer cell lines compared to normal PBMC cells. As well, entacapone treatment (140 μM) can induce apoptosis (KYSE‐30: 50%. YM‐1:22.6%) and has a modulatory effect on cell cycle progression in both YM‐1 and KYSE‐30 cells (p‐value<.05). However, no significant difference in the m6A concentration was observed.ConclusionOur findings suggested that entacapone has the inhibitory effect on ESCC cell lines through induction of the apoptosis and modulation of the cell cycle without toxicity on the normal PBMC.
Human activity recognition based on integration of multilayer information of convolutional neural network architecture
Authors: Kushwaha Arati , Srivastava Prashant , Khare Ashish 
Published: December 2022

SummaryHuman activity recognition (HAR) has gained researcher's interest due to its increasing demand in automated monitoring applications. Development of efficient HAR algorithm is still an open research area due to the challenges like inter and intra‐class variations, diversity in lighting conditions, view point changes, and complex object motions. Convolutional neural network (CNN) based methods have achieved significant improvement in HAR. However, CNN implementations have drawback that it require a lot of computational resources due to the use of large number of learnable parameters. To overcome this drawback, we propose a simple and computationally efficient deep CNN architecture using multi‐layer information fusion for HAR. In this study, we explore the impact of information fusion at intermediate layers of the network, as each convolutional layer of the network hierarchically extracts information at different level of abstraction of the objects from the video frames. In this work, first we designed a simple and computationally efficient deep CNN architecture and then we introduce a feature fusion strategy to integrate the complementary information of intermediate layers to the layer of the proposed CNN architecture. The proposed architecture is fine‐tuned and trained from scratch with raw RGB data. Softmax classifier is used at the last layer of network for activity classification. Benefits of the proposed architecture over standard deep learning architectures is it's high computational efficiency and reduced requirement of computational resources. To prove the effectiveness of the proposed method, we performed several extensive experiments on publically available datasets. The experimental results of the proposed method have demonstrated its superiority over other existing state‐of‐the‐art methods.
Ultra‐Thin Layer Inside Separator Deposited by Spray Pyrolysis Using Methylaluminoxane Solution
Authors: Imai Masato , Kubota Tadahiko , Miyazawa Atsushi , Aoki Masahiro , Mori Haruna , Komaki Yuta , Yoshino Kenji 
Published: December 2022

AbstractDepositions are conducted on monolayer porous membrane at 50 °C by spray pyrolysis using methylaluminoxanes diluted with N‐methylpyrrolidone. The solution penetrates the film during spraying and the ultra‐thin layers are deposited on the side wall of internal pores. It is suggested that these layers are fine polycrystalline of Al2O3. In the obtained film, most of the pores are exposed on the surface and there is no increase in film thickness. Further, the ionic conductivity is the same as that of the received film, and the thermal stability is improved. This method can be an effective technique for improving the function of the separator used in the lithium‐ion batteries.
Reduced early response to SARS‐CoV2 vaccination in people with type 1 and type 2 diabetes, a 6 months follow‐up study: The CoVaDiab study I
Authors: D’Onofrio Luca , Fogolari Marta , Amendolara Rocco , Siena Antonio , De Fata Riccardo , Davini Flavio , Coraggio Lucia , Mignogna Carmen , Moretti Chiara , Maddaloni Ernesto , Angeletti Silvia , Buzzetti Raffaella 
Published: December 2022

AbstractIntroductionDiabetes mellitus worsens the prognosis of SARS‐CoV‐2 infection, and vaccination has been the major tool for reducing the risk of hospitalisation, and mortality.The primary aim of this study was to evaluate the response to the SARS‐CoV‐2 vaccine in subjects with diabetes and controls. Differences between type 1 (T1D) and type 2 (T2D) diabetes and clinical determinants of vaccination response were also evaluated.Methods128 subjects with diabetes (60 with T1D and 62 with T2D) and 202 subjects acting as controls who completed a full vaccination cycle with two doses of mRNA vaccine were enroled. People with previous SARS‐CoV‐2 infection were excluded. Antibodies (Ab) directed against the spike protein of the SARS‐CoV‐2 were evaluated at one and 6 months after vaccination.ResultsIn the whole cohort, the Ab level was higher among women than in men (p = 0.011) and negatively correlated with age (rho = −0.155, p = 0.005). Subjects with diabetes showed decreased levels of Ab after one month compared to controls (1217[747–1887]BAU/mL vs. 1477[942–2556]BAU/mL, p = 0.002), even after correction for age and gender (p = 0.002). No difference was found between subjects with T1D and T2D. After 6 months, antibody levels significantly decreased in people with and without diabetes, with no differences between groups, although some subjects were lost at follow‐up. In subjects with diabetes, only a significant correlation was found between Ab level and renal function (rho 0.190, p = 0.042).ConclusionsBoth T1D and T2D are associated with a reduced early response to vaccination. The serum concentration of Ab significantly reduced over time in both groups, highlighting the relevance of vaccination boosters independently of the presence of diabetes.
Base41: A proposal for printable encoding of bit strings
Authors: Botta Marco , Cavagnino Davide 
Published: December 2022

AbstractThis article presents the proposal of a novel encoding method for representing binary data in printable format. The encoding procedure reversibly transforms binary strings into printable letter sequences using a mapping from bit strings to an alphabet of 41 symbols taken from a subset of the English uppercase and lowercase letters. The decoding process reversibly recovers an original bit string from the encoded printable string. The encoding and decoding algorithms along with the properties of this coding are examined and discussed. In particular, the use of only URL‐safe and clearly visually distinguishable characters is emphasized.
Safety and tolerability of short‐term infusions of intravenous lacosamide in pediatric patients with epilepsy: An open‐label, phase 2/3 trial
Authors: Farkas Mark Kristof , Beller Cynthia , Bozorg Ali , McClung Carrie , Roebling Robert , Yates Tanisia , Yuen Nancy , Makedonska Iryna 
Published: December 2022

AbstractObjectiveThe objective of this study is to evaluate the safety and tolerability of intravenous (IV) lacosamide infusion in patients aged ≥1 month to <17 years with epilepsy.MethodsThis Phase 2/3 open‐label trial (EP0060; NCT02710890) enrolled patients in two age cohorts (cohort 1: ≥8 to <17 years; cohort 2: ≥1 month to <8 years). Eligible patients were receiving oral lacosamide as adjunctive treatment or monotherapy (in an open‐label long‐term trial or by prescription) or were not receiving lacosamide before enrolment. Patients initiated IV lacosamide (2‐12 mg/kg/day or 100‐600 mg/day; 15‐60 minutes infusion) as a replacement for oral lacosamide or as adjunctive treatment. The primary outcomes were treatment‐emergent adverse events (TEAEs) and discontinuations due to TEAEs.ResultsIn total, 103 patients were enrolled and completed the trial; 55 patients were included in cohort 1 (≥8 to <17 years), 48 in cohort 2 (≥1 month to <8 years). During the 4 weeks before screening, 74 (71.8%) patients had focal seizures, 12 (11.7%) had generalized seizures, and two (1.9%) had unclassified seizures. Most patients (74 [71.8%]) initiated lacosamide as adjunctive IV treatment. The mean overall duration of exposure to IV lacosamide was 1.18 days. Seventy‐nine (76.7%) patients had one IV lacosamide infusion, 20 (19.4%) had two, one (1.0%) had three, and three (2.9%) had 10 infusions. Overall, five (4.9%) patients had a total of seven TEAEs. The only TEAEs reported in two or more patients were increased blood triglycerides (two [1.9%]). No serious or severe TEAEs were reported, and no patients discontinued due to TEAEs. No TEAEs were considered drug‐related by the investigator. No consistent or clinically relevant treatment‐related changes from baseline were observed for hematology, clinical chemistry parameters, vital signs, or 12‐lead electrocardiograms.SignificanceIV lacosamide was generally well tolerated in pediatric patients (≥1 month to <17 years) with epilepsy, and no new safety concerns were identified.
Is time‐restricted eating (8/16) beneficial for body weight and metabolism of obese and overweight adults? A systematic review and meta‐analysis of randomized controlled trials
Authors: Huang Lu , Chen Yan , Wen Shu , Lu Danhua , Shen Xiaoyang , Deng Hongxia , Xu Liangzhi 
Published: December 2022

AbstractTime‐restricted eating (TRE) is a new therapeutic strategy for the management of weight loss and dysmetabolic diseases. At present, TRE (8/16, 8 h eating:16 h fasting) is the most common form of TRE. Therefore, this meta‐analysis included randomized controlled trials (RCTs) on TRE (8/16) in overweight and obese adults to determine its impact on body weight and metabolism. Articles reviewed from PubMed, Ovid MEDLINE, Embase, and Cochrane Central Register for the relevant RCTs that compared TRE (8/16) to non‐TRE in overweight and obese adults. Eight RCTs were included in this meta‐analysis. Participants following TRE (8/16) showed significant body weight reduction (mean difference [MD]: −1.48 kg, 95% confidence interval [CI]: −2.53 to −0.44) and fat mass reduction (MD: −1.09 kg, 95% CI: −1.55 to −0.63). There was no significant difference in lean mass change with TRE intervention (MD: −0.48 kg, 95% CI: −1.02 to 0.05, p = .08, I2 = 41%). The energy restriction and early TRE (eTRE) subgroups resulted in greater weight loss. TRE (8/16) showed beneficial effects on the homeostatic model assessment of insulin resistance (HOMA‐IR, MD: −0.32, 95% CI: −0.59 to −0.06), but had no significant effect on other parameters of glucose metabolism and lipid profiles. In conclusion, TRE (8/16), especially eTRE, or in combination with caloric intake restriction, is a potential therapeutic strategy for weight control in overweight and obese adults. TRE (8/16) also reduced HOMA‐IR; therefore, it may have a positive effect on glucose metabolism.
Investigation of the influence of Pt/C percentage and humidity on the voltage decay rate of proton exchange membrane fuel cell
Authors: Mathan C. , Karthikeyan P. , Dineshkumar P. , Thanarajan K. 
Published: December 2022

AbstractVoltage degradation is the main parameter that determines the effective usable life of a fuel cell, here the influence of Pt/C% and relative humidity (RH%) on the voltage decay rate of a fuel cell is experimentally evaluated and reported. This study implements a stress test with frequent interrupts of purging for determining the durability of the fuel cells. In the course of the 1456 h stress test for each membrane electrode assembly (MEA), the polarization curve and electrochemical impedance spectroscopy (EIS) were measured. The experimental results make it evident that the lowest voltage degradation was 6 µV/h for MEA with 40% Pt/C tested under 70% RH while the highest was 183 µV/h recorded for MEA with 20% Pt/C tested under 90% RH. From EIS results, the ohmic resistance increased for all the tested MEAs, which is also reflected in the performance degradation. Field emission scanning electron microscopy images also indicate the delamination of MEA layers which in turn increases the electron transfer resistance. So, the decisive factors for the fuel cell performance degradation were flooding, catalyst surface contamination, and delamination of MEA layers due to repeated mechanical and chemical stresses.
Feasibility of ipsilateral elective neck irradiation of levels Ib and II without level III in patients with node‐negative sinonasal squamous cell carcinoma
Authors: Liu Qian , Lun Lixin , Sun Meng , Wang Zekun , Huang Xiaodong , Chen Xuesong , Wang Jingbo , Zhang Jianghu , Qu Yuan , Wang Kai , Wu Runye , Zhang Ye , Xiao Jianping , Yi Junlin , Luo Jingwei 
Published: December 2022

AbstractBackgroundThe necessity of level III irradiation in patients with node‐negative advanced sinonasal squamous cell carcinoma (SNSCC) is unclear.MethodsSeventy‐eight patients with advanced SNSCC were included. Survival rates were estimated and compared between treatment groups.ResultsTwenty‐five patients received ipsilateral levels Ib and II irradiation (group 1) and 53 patients received ipsilateral levels Ib and II plus level III irradiation (group 2). The median follow‐up time was 75.56 months. Five‐year survival rates (regional relapse‐free survival, overall survival, local relapse‐free survival, and distant metastasis‐free survival) were similar between groups 1 and 2 (all p > 0.05). Irradiation doses to the thyroid and larynx were significantly lower in group 1 than in group 2.ConclusionsIpsilateral irradiation of levels Ib and II neck provides similar regional control and results as irradiation of these levels plus level III, with lower irradiation doses to normal neck tissue, in patients with node‐negative advanced SNSCC.
Long telomeres at baseline and male sex are main determinants of telomere loss following chemotherapy exposure in lymphoma patients
Authors: Derenzini Enrico , Gueli Angela , Risso Alessandra , Bruna Riccardo , Gottardi Daniela , Cignetti Alessandro , Pileri Stefano , Avvedimento Enrico V. , Tarella Corrado 
Published: December 2022

AbstractAlthough chemotherapy (CHT) exposure is an established cause of telomere attrition, determinants of telomere length (TL) dynamics after chemotherapy are poorly defined. In this study, we analyzed granulocyte telomere dynamics in 34 adult lymphoma patients undergoing first‐line CHT. TL was measured by southern blot at each CHT cycle and after 1 year from CHT completion. Median age was 59 yrs (range 22–77). Median number of CHT cycles was 6 (range 3–6). The majority of patients (79%, n = 27) experienced TL shortening following CHT exposure. Mean telomere loss was 673 base pairs (bp) by cycle 6. Telomere shortening was an early event as 87% of the total telomere loss (mean 586 bp) occurred by the end of cycle 3, with no significant recovery after 1 year. A significant correlation was observed between baseline TL and total or fractional telomere loss (p < 0.001), with telomere shortening by cycle 3 observed predominantly in male patients with long telomeres at pre‐treatment evaluation. Stratifying the analysis by gender and age only young women (<51 years of age) did not show significant telomere shortening following chemotherapy exposure. These findings indicate that gender and baseline TL are major determinants of TL dynamics following chemotherapy exposure in lymphoma patients.
Effect of low thermal conductivity wick on the performance of compact loop heat pipe
Authors: Veeramachaneni Sireesha , Pisipaty Srinivas K. , Brusly Solomon Arulanantham , Vadisa Venkata C. , Vedula Dharma R. , Srinivasa Rao Devisetty 
Published: December 2022

AbstractThe existing work deals with the evaluation of compact loop heat pipe by means of a low thermal conductivity sintered chrysotile wick to avoid large heat leaks as of the evaporator to the compensation chamber. Accordingly, a wick with low thermal conductivity (0.068–0.098 W/mK) chrysotile powder of a mean particle diameter of 3.4 μm is fabricated through sintering. Nine chrysotile wicks are sintered with different compositions of binders (bentonite and dextrin) and pore‐forming agent NaCl at sintering temperatures of 500°C, 600°C, and 700°C with a sintering time of 30 min. The wick properties, for instance, porosity, permeability, wettability, and capillary rise are studied owing to sintering temperature. Consequently, it is observed that a pure chrysotile powdered wick at a sintering temperature of 600°C exhibits a high porosity of 61.8% with permeability 1.04 × 10−13 m2 and a capillary rise of 4.5 cm in 30 s and is considered optimal. This optimal wick is used for performance evaluation in compact loop heat pipe and a decrease of 36.1% in thermal resistance is found when compared with copper mesh wick in a loop heat pipe. The lowermost thermal resistance originates to be 0.147 K/W at 120 W with wall temperature 57.7°C. This indicates that loop heat pipe with sintered chrysotile wick can operate at lower heat loads efficiently when compared with copper mesh wick and as heat load increases a chance of dry out condition occurs. The highest evaporative heat transfer coefficient obtained is 65.7 kW/m2 K at a minimum heat load.