bluuebunny/crossref_metadata_2025_split huggingface dataset:
A beaker cist at Chapelden, Tore of Troup, Aberdour, Banff and Buchan District, with a note on the orientation of beaker burials in north-east Scotland
Authors: Greig Moira K , Greig Colvin , Shepherd Alexandra N , Shepherd Ian A G 
Published: March 2023

The burial of an adult male accompanied by a complete N4/Step ?4 beaker within the cist and sherds of an indeterminate beaker on the capstone is described. A review of the evidence suggests that the same beaker burial pattern existed in north-east Scotland as has been observed in east Yorkshire.
Risk Factors Associated With Post−COVID-19 Condition
Authors: Tsampasian Vasiliki , Elghazaly Hussein , Chattopadhyay Rahul , Debski Maciej , Naing Thin Kyi Phyu , Garg Pankaj , Clark Allan , Ntatsaki Eleana , Vassiliou Vassilios S. 
Published: March 2023

ImportancePost−COVID-19 condition (PCC) is a complex heterogeneous disorder that has affected the lives of millions of people globally. Identification of potential risk factors to better understand who is at risk of developing PCC is important because it would allow for early and appropriate clinical support.ObjectiveTo evaluate the demographic characteristics and comorbidities that have been found to be associated with an increased risk of developing PCC.Data sourcesMedline and Embase databases were systematically searched from inception to December 5, 2022.Study SelectionThe meta-analysis included all published studies that investigated the risk factors and/or predictors of PCC in adult (≥18 years) patients.Data Extraction and SynthesisOdds ratios (ORs) for each risk factor were pooled from the selected studies. For each potential risk factor, the random-effects model was used to compare the risk of developing PCC between individuals with and without the risk factor. Data analyses were performed from December 5, 2022, to February 10, 2023.Main Outcomes and MeasuresThe risk factors for PCC included patient age; sex; body mass index, calculated as weight in kilograms divided by height in meters squared; smoking status; comorbidities, including anxiety and/or depression, asthma, chronic kidney disease, chronic obstructive pulmonary disease, diabetes, immunosuppression, and ischemic heart disease; previous hospitalization or ICU (intensive care unit) admission with COVID-19; and previous vaccination against COVID-19.ResultsThe initial search yielded 5334 records of which 255 articles underwent full-text evaluation, which identified 41 articles and a total of 860 783 patients that were included. The findings of the meta-analysis showed that female sex (OR, 1.56; 95% CI, 1.41-1.73), age (OR, 1.21; 95% CI, 1.11-1.33), high BMI (OR, 1.15; 95% CI, 1.08-1.23), and smoking (OR, 1.10; 95% CI, 1.07-1.13) were associated with an increased risk of developing PCC. In addition, the presence of comorbidities and previous hospitalization or ICU admission were found to be associated with high risk of PCC (OR, 2.48; 95% CI, 1.97-3.13 and OR, 2.37; 95% CI, 2.18-2.56, respectively). Patients who had been vaccinated against COVID-19 with 2 doses had a significantly lower risk of developing PCC compared with patients who were not vaccinated (OR, 0.57; 95% CI, 0.43-0.76).Conclusions and RelevanceThis systematic review and meta-analysis demonstrated that certain demographic characteristics (eg, age and sex), comorbidities, and severe COVID-19 were associated with an increased risk of PCC, whereas vaccination had a protective role against developing PCC sequelae. These findings may enable a better understanding of who may develop PCC and provide additional evidence for the benefits of vaccination.Trial RegistrationPROSPERO Identifier: CRD42022381002
Disparities in Survival Due to Social Determinants of Health and Access to Treatment in US Patients With Operable Malignant Pleural Mesothelioma
Authors: Alnajar Ahmed , Kareff Samuel A. , Razi Syed S. , Rao J. Sunil , De Lima Lopes Gilberto , Nguyen Dao M. , Villamizar Nestor , Rodriguez Estelamari 
Published: March 2023

ImportanceOutcomes of localized malignant pleural mesothelioma (MPM) remain poor despite multimodality therapy. It is unclear what role disparities have in the overall survival (OS) of patients with operable MPM.ObjectiveTo examine survival disparities associated with social determinants of health (SDOHs) and treatment access in patients with malignant pleural mesothelioma.Design, Setting, and ParticipantsIn this observational, retrospective cohort study, patients with MPM diagnosed between January 1, 2004, and December 31, 2017, were identified from the National Cancer Database with a maximum follow-up time of 13.6 years. The analysis was conducted from February 16, 2022, to July 29, 2022. Patients were included if they were diagnosed with potentially resectable clinical stage I to IIIA MPM, had epithelioid and biphasic histologic subtypes, and received chemotherapy. Patients were excluded if they could not receive curative surgery, were 75 years or older, or had metastasis, unknown stage, or tumor extension to the chest wall, mediastinal tissues, or organs.ExposuresChemotherapy alone vs chemotherapy with curative surgery in the form of pleurectomy and decortication or extrapleural pneumonectomy.Main Outcomes and MeasuresThe primary end point was OS. Cox proportional hazards regression models were used to determine hazard ratios (HRs) for OS, including univariable and multivariable models controlling for potential confounders, including demographic, comorbidity, clinical, treatment, tumor, and hospital-related variables, as well as SDOHs.ResultsA total of 1389 patients with MPM were identified (median [IQR] age, 66 [61-70] years; 1024 [74%] male; 12 [1%] Asian, 49 [3%] Black, 74 [5%] Hispanic, 1233 [89%] White, and 21 [2%] of other race). The median OS was 1.7 years (95% CI, 1.6-1.8). Risk factors associated with worse OS included older age, male sex, Black race, low income, and low educational attainment. Factors associated with greater odds of survival included receipt of surgical therapy, recent year of treatment, increased distance to travel, and treatment at high-volume academic hospitals. The risk factors most strongly associated with poor OS included Black race (HR, 1.96; 95% CI, 1.43-2.69) and male sex (HR, 1.60; 95% CI, 1.38-1.86). Surgical treatment in addition to systemic chemotherapy (HR, 0.70; 95% CI, 0.61-0.81) was independently associated with improved OS, as were chemotherapy initiation (HR, 0.93; 95% CI, 0.87-0.99) and greater travel distance from the hospital (HR, 0.92; 95% CI, 0.86-0.98).Conclusions and RelevanceIn this retrospective cohort study of patients with operable MPM, there was significant variability in access to care by SDOHs. Addressing disparities in access to multimodality therapy can help ensure equity of care for patients with MPM.
Improvement of obsessive–compulsive disorder after pallidothalamic tractotomy for cervical dystonia
Authors: Horisawa Shiro , Kamba Rumiko , Sato Moeko , Sueki Akitsugu , Kawamata Takakazu , Nishimura Katsuji , Taira Takaomi 
Published: March 2023

AbstractA 30‐year‐old woman with tardive dystonia in the cervical region from long‐term antipsychotic meds was treated with radiofrequency ablation of the right pallidothalamic tract in the fields of Forel. The patient showed improvement in both cervical dystonia and obsessive–compulsive disorder after the procedure, with 77.4% improvement in cervical dystonia and 86.7% improvement in obsessive–compulsive disorder. Although the treatment site in this case was intended to treat cervical dystonia, the lesion was located in the optimal stimulation network for both obsessive–compulsive disorder and cervical dystonia, suggesting that neuromodulation of this region could potentially treat both simultaneously.
Age and skill in chess: Accuracy and speed‐accuracy performance in reasoning and knowledge
Authors: Blanch Angel , Martínez Albert 
Published: March 2023

AbstractIndividual differences in cognitive performance depend on age, skill, and type of task. Nonetheless, whether performance is measured with accuracy (ACC) or with the trade‐off between responding speed and accuracy (SAT) could render subtle different relationships. Age and skill might associate more strongly with SAT performance in reasoning tasks, whereas they might relate more similarly with either ACC or SAT in knowledge tasks. These expectations were evaluated here with data from the cognitively taxing domain of chess (n = 259). Age was associated more strongly with the SAT than with the ACC measures in reasoning tasks. In contrast, skill related more robustly with the ACC than with the SAT measures in knowledge tasks. The main findings suggest that the associations of age and skill with performance vary depending on the type of task, but also on whether considering accuracy or speed‐accuracy measures of cognitive performance.
Discovering New Type of Lead‐Free Cluster‐Based Hybrid Double Perovskite Derivatives with Chiral Optical Activities and Low X‐Ray Detection Limit
Authors: Zhu Zeng‐Kui , Zhu Tingting , Wu Jianbo , You Shihai , Yu Panpan , Liu Xitao , Li Lina , Ji Chengmin , Luo Junhua 
Published: March 2023

Abstract2D chiral hybrid perovskites have recently emerged as outstanding semiconductor materials. However, most of the reported 2D chiral perovskites have limited structural types and contain high levels of toxic lead, which severely hinders their further applications. Herein, by using a mixed‐cation strategy, an unprecedented type of lead‐free cluster‐based 2D chiral hybrid double perovskite derivatives are successfully obtained, [(R/S‐PPA)4(IPA)6Ag2Bi4I24]·2H2O (1‐R and 1‐S), and [(R/S‐PPA)4(n‐BA)6Ag2Bi4I24]·2H2O (2‐R and 2‐S) (R/S‐PPA=R/S–1‐phenylpropylamine; IPA=isopentylamine; n‐BA=n‐butylamine). Their inorganic skeletons are linked by binuclear {Bi2I10} and infinite chain {Ag2Bi2I14}∞, in which bismuth clusters and multiple coordination modes (e.g., tetrahedral AgI4 and octahedral AgI6) are introduced into the double perovskite system for the first time. This introduction induces distortion of the inorganic layer, which may facilitate the transfer of chirality from the chiral cations into achiral double perovskite skeletons. Further, circular dichroism measurements and circularly polarized light detection confirm their inherent chiral optical activities. In addition, 1‐S exhibits an ultralow X‐ray detection limit of 129.5 nGy s−1, which is 42‐fold lower than that of demands in regular medical diagnosis (5.5 µGy s−1). This study provides a pathway to construct novel type of lead‐free cluster‐based double perovskite derivatives.
Injectable Scaffolds for In Vivo Programmed Macrophages Manufacture and Postoperative Cancer Immunotherapy
Authors: Wu Xiaodan , Zhong Zhenyu , Li Yan , Wang Yifan , Tian Yaping , Liu Xulong , Zhang Xin , Tao Weiyong , Wang Jianglin , Du Yingying , Zhang Shengmin 
Published: March 2023

AbstractCancer recurrence and metastasis after surgical resection is a vital reason of treatment failure. The modification of immune cells through implanted biomaterials is a promising postoperative immunotherapy. Herein, an injectable hydrogel scaffold loaded with engineered exosome mimetics that in vivo recruits and programs endogenous macrophages into M1 binding with anti‐CD47 antibody (M1‐aCD47 macrophages) for postoperative cancer immunotherapy is developed. Briefly, M1 macrophages‐derived exosome mimetics co‐modified with vesicular stomatitis virus glycoprotein (VSV‐G) and aCD47 (V‐M1EM‐aCD47) are encapsulated in injectable chitosan hydrogel. Such hydrogel recruits inherent macrophages in situ and releases V‐M1EM‐aCD47 that programs M2 to M1‐aCD47 macrophages. M1‐aCD47 macrophages own dual‐functions of tumor‐homing and enhanced phagocytosis. They can actively target to tumor cells for delivery of aCD47 that blocks the “don't eat me” signal, thereby promoting phagocytosis of macrophages to cancer cells. Furthermore, V‐M1EM‐aCD47 hydrogel implanted into resection site of 4T1 breast tumor inhibits tumor recurrence and metastasis by phagocytosis of M1‐aCD47 macrophages and T cell‐mediated immune responses. The findings demonstrate that biomaterials can be designed in vivo to program inherent macrophages, thereby activating the innate and adaptive immune systems for prevention of postoperative tumor recurrence and metastasis.
Surface Modification of a Titanium Carbide MXene Memristor to Enhance Memory Window and Low‐Power Operation
Authors: Mullani Navaj B. , Kumbhar Dhananjay D. , Lee Do‐Hyeon , Kwon Mi Ji , Cho Su‐yeon , Oh Nuri , Kim Eui‐Tae , Dongale Tukaram D. , Nam Sang Yong , Park Jun Hong 
Published: March 2023

AbstractWith the demand for low‐power‐operating artificial intelligence systems, bio‐inspired memristor devices exhibit potential in terms of high‐density memory functions and the emulation of the synaptic dynamics of the human brain. The 2D material MXene attracts considerable interest for use in resistive‐switching memory and artificial synapse devices owing to its excellent physicochemical properties in memristor devices. However, few memristive and synaptic MXene devices that display increased switching performances are reported, with no significant results. Herein, the conductivity of MXene (Ti3C2Tx) is engineered via etching and oxidation to enhance the switching performance of the device. The exceptional properties of partially oxidized MXene memristors include large memory windows and low threshold biases, and the complex spike‐timing‐dependent plasticity synaptic rules are also emulated. The low threshold potential distribution, reliable retention time (104 s), and distinct resistance states with a high ON–OFF ratio (>104) are the main memory‐related features of this device. The experimentally determined switching potentials of the optimized device are also uniformly distributed, according to a statistical probability‐based approach. This investigation may promote the essential material properties for use in high‐density non‐volatile memory storage and artificial synapse systems in the field of innovative nanoelectronic devices.
Phase Change Hydrogels for Bio‐Inspired Adhesion and Energy Exchange Applications
Authors: Fang Yuanlai , Xiong Xinhong , Yang Li , Yang Wanyou , Wang Hong , Wu Qian , Liu Qianwei , Cui Jiaxi 
Published: March 2023

AbstractThe adhesion strategies of the gecko's toe through surface adaptation of spatulas to increase contact area and the snail's epiphragm via dehydration‐induced solidification to lock interfaces are combined to design a class of adhesion‐switchable hydrogels. The hydrogels are made via incorporating CH3COONa·3H2O salt (SA) into polyacrylamide (PAM) aqueous networks to construct supersaturated and stimuli‐responsive phase change materials (PAM‐SA). The crystallization dramatically strengthens the mechanical properties, and tensile Young's moduli are 340.7 and 0.1 MPa for crystalline C‐PAM‐SA‐120% and soft PAM hydrogel. As a result, PAM‐SA‐120% shows excellent adhesive performance (adhesion strength, 348 kPa) compared with PAM hydrogel adhesive (adhesion strength, 7 kPa). The stimuli‐induced crystallization from H‐PAM‐SA‐120% phase change hydrogels releases thermal controllably, which can be utilized for thermochromic materials and thermotherapy.
Plant Protein‐Peptide Supramolecular Polymers with Reliable Tissue Adhesion for Surgical Sealing
Authors: Nie Junlian , Sun Yingchuan , Cheng Xueliang , Wen Guang , Liu Xiaohuan , Cheng Meng , Zhao Jianwu , Li Wen 
Published: March 2023

AbstractThe fusion of protein science and peptide science opens up new frontiers in creating innovative biomaterials. Herein, a new kind of adhesive soft materials based on a natural occurring plant protein and short peptides via a simple co‐assembly route are explored. The hydrophobic zein is supercharged by sodium dodecyl sulfate to form a stable protein colloid, which is intended to interact with charge‐complementary short peptides via multivalent ionic and hydrogen bonds, forming adhesive materials at macroscopic level. The adhesion performance of the resulting soft materials can be fine‐manipulated by customizing the peptide sequences. The adhesive materials can resist over 78 cmH2O of bursting pressure, which is high enough to meet the sealing requirements of dural defect. Dural sealing and repairing capability of the protein‐peptide biomaterials are further identified in rat and rabbit models. In vitro and in vivo assays demonstrate that the protein‐peptide adhesive shows excellent anti‐swelling property, low cell cytotoxicity, hemocompatibility, and inflammation response. In particular, the protein‐peptide supramolecular biomaterials can in vivo dissociate and degrade within two weeks, which can well match with the time‐window of the dural repairing. This work underscores the versatility and availability of the supramolecular toolbox in the easy‐to‐implement fabrication of protein‐peptide biomaterials.
Design, Synthesis and Application of C2‐Symmetric Cycloglycerodiphosphate Catalysts
Authors: Antenucci Achille , Ghigo Giovanni , Cassetta Davide , Alcibiade Marco , Dughera Stefano 
Published: March 2023

AbstractChiral phosphoric acids (CPAs) and their salts are the privileged catalysts in a plethora of asymmetric transformations. All of the scaffolds of efficient CPAs rely on C2‐symmetry and axial chirality, while the only examples of punctually chiral CPAs are TADDOL derivatives. Herein, we present the design and the synthesis of C2‐symmetric cycloglycerophosphates (cGPAs) and their application throughout the addition of trimethylsilyl cyanide (TMSCN) to aldehydes and ketones, to obtain the corresponding cyanohydrins in yields between 77 and 99% and ee between 84.2 and 99.5% (27 examples). A DFT computational model is moreover performed to rationalize the reaction mechanism and its stereochemical outcome.magnified image
Design of Lysozyme‐Templated Biocompatible Fluorescent Nanocomposites and Their Potential Applications for Cell Imaging, Hydrogen Peroxide Sensing, and Cancer Therapy
Authors: Das Sourav , Tripathy Sanchita , Sreedhar Bojja , Mukherjee Sudip , Patra Chitta Ranjan 
Published: March 2023

AbstractRecently, multifunctional metal‐based nanocomposites gained immense importance in various biomedical applications. Here, a simple approach is reported to synthesize fluorescent bimetallic nanocomposites (NCs) of silver‐gold (Ag@Au NC) and silver‐platinum (Ag@Pt NC) by reducing silver nitrate (AgNO3) on gold nanoparticles and platinum nanoparticles (AuNPs, PtNPs), respectively, in the presence of lysozyme that acts as capping agent. Various in vitro (in normal cells including Chinese hamster ovarian and human umbilical vein endothelial cells) and in vivo (in mouse and chicken egg chorioallantoic membrane model) studies reveal the biocompatibility of these nanocomposites. However, these NCs show inhibition of cancer cell proliferation when treated to various cancer cells (MCF‐7, MDA‐MB‐231, and B16F10), indicating their anticancer property. Intraperitoneal administration of these NCs resulted in the regression of melanoma tumor in C57BL/6J mouse model. Further, these NCs displayed green fluorescence inside MCF‐7 cells facilitating in vitro live‐cell imaging and sense hydrogen peroxide (H2O2) in cellular level (B16F10 and MCF‐7) using their fluorescence enhancement property in presence of H2O2.The results (in vitro and in vivo) altogether demonstrate the promising multifunctional applications of bimetallic nanocomposites (NCs) that can be utilized as promising transformative drugs in cancer theranostics applications.
Oleic Acid Dissolves cGAS–DNA Phase Separation to Inhibit Immune Surveillance
Authors: Wang Lina , Liu Qiaoling , Wang Na , Li Siru , Bian Wei , Sun Zhen , Wang Lulu , Wang Li , Liu Caigang , Song Chengli , Liu Quentin , Yang Qingkai 
Published: March 2023

AbstractPhase separation (PS) is a fundamental principle in diverse life processes including immunosurveillance. Despite numerous studies on PS, little is known about its dissolution. Here, it is shown that oleic acid (OA) dissolves the cyclic GMP–AMP synthase (cGAS)–deoxyribonucleic acid (DNA) PS and inhibits immune surveillance of DNA. As solvent components control PS and metabolites are abundant cellular components, it is speculated that some metabolite(s) may dissolve PS. Metabolite‐screening reveals that the cGAS–DNA condensates formed via PS are markedly dissolved by long‐chain fatty acids, including OA. OA revokes intracellular cGAS–PS and DNA‐induced activation. OA attenuates cGAS‐mediated antiviral and anticancer immunosurveillance. These results link metabolism and immunity by dissolving PS, which may be targeted for therapeutic interventions.
Biomimetic Enzyme Cascade Structural Color Hydrogel Microparticles for Diabetic Wound Healing Management
Authors: Wang Li , Chen Guopu , Fan Lu , Chen Hanxu , Zhao Yuanjin , Lu Ling , Shang Luoran 
Published: March 2023

AbstractHard‐healing diabetic wound brings burgeoning physical and mental burdens to patients. Current treatment strategies tend to achieve multistage promotion and real‐time reporting to facilitate wound management. Herein, a biomimetic enzyme cascade inverse opal microparticles system for wound healing, which is intergated with glucose oxidase (GOD) and copper peroxide (CP). Such microparticles are composed of biofriendly hyaluronic acid methacryloyl (HAMA) and pH‐responsive acrylic acid (AA), which provided abundant binding sites and spaces for chemical immobilizing and physical doping of enzymes and metal bioinorganics. When the cascade catalytic system is applied on wound sites, hyperglycemia environment would serve as a hydrogen peroxide (H2O2) generator through GOD catalysis, while acidic environment triggers the decomposition of CP, further catalyzing H2O2 to generate reactive oxygen species (ROS). Additionally, the distinctive structural color of the microparticles can visually reflect the wound pH and intelligently estimate the healing state. It is demonstrated that such microparticle systems exhibit excellent broad‐spectrum antibacterial and angiogenesis‐promoting properties, as well as significant real‐time reporting ability for wound healing. These features indicate that enzyme cascade structural color microparticles possess valuable potential in wound healing and related field.
A Dendrimer Peptide (KK2DP7) Delivery System with Dual Functions of Lymph Node Targeting and Immune Adjuvants as a General Strategy for Cancer Immunotherapy
Authors: Zhang Rui , Tang Lin , Wang Yusi , Tian Yaomei , Wu Siwen , Zhou Bailing , Dong Chunyan , Zhao Binyan , Yang Yuling , Xie Daoyuan , Yang Li 
Published: March 2023

AbstractThe clinical efficacy of personalized cancer vaccines still needs to be improved due to their insufficient immune effect. The development of innovative adjuvants and lymph node‐targeted delivery systems is the key to improving the clinical efficacy of personalized vaccines. However, there is still a lack of an adjuvant delivery system that is simple in preparation and capable of mass production and integrates adjuvant and lymph node targeted delivery functions. Here, this work reports that a simple dendrimer polypeptide (KK2DP7) nanoparticle enhances the immune efficacy of an OVA/neoantigen‐based vaccine. Due to its multiple functions as a delivery vehicle, immune adjuvant, and facilitator of dendritic cell migration, KK2DP7 efficiently increases the efficiency of antigen uptake and cross‐presentation by antigen‐presenting cells (APCs) and delivers antigens to lymph nodes via APCs. Strikingly, the antitumor effect of KK2DP7/OVA is superior to that of commonly used adjuvants such as poly(I:C), CpG, and aluminum adjuvant combined with OVA. Furthermore, KK2DP7/OVA combined with anti‐PD‐1 antibody is able to prevent tumor recurrence in a postoperative recurrent tumor model. Thus, KK2DP7‐based cancer vaccines alone or in combination with immune checkpoint blockade therapies to treat tumors or postoperative tumor recurrence are a powerful strategy to enhance antitumor immunity.