bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining Intensive Rehabilitation With a Nonfunctional Isokinetic Strengthening Program in Adolescents With Cerebral Palsy: Protocol for a Randomized Controlled Trial
Authors: Guérin Mathias , Sijobert Benoit , Zaragoza Benjamin , Cambon Flore , Boyer Laurence , Patte Karine 
Published: December 2022

Background
Cerebral palsy is the most common brain injury in the pediatric population. Patients with cerebral palsy present different affectations such as decreased muscle strength, gait deviations, impaired proprioception, and spasticity. Isokinetic strengthening programs combined with intensive rehabilitation may improve muscle strength and therefore gait efficiency.

Objective
The primary aim of this randomized controlled trial is to compare the effect of an intensive rehabilitation combined with a nonfunctional isokinetic progressive strengthening program to an intensive rehabilitation alone on gait parameters and muscle strength in patients with cerebral palsy. Another goal of this study is to determine whether adding an isokinetic program to intensive rehabilitation is more effective than intensive rehabilitation alone at decreasing spasticity and improving joint position sense in patients with cerebral palsy.

Methods
A total of 30 adolescents with spastic diplegia cerebral palsy (Gross Motor Function Classification System levels I to III) will be randomized, by an independent researcher, into a 3-week intensive rehabilitation and isokinetic progressive strengthening group or an intensive rehabilitation control group. Gait parameters, muscle strength, spasticity, and knee joint position sense will be assessed. These variables will be evaluated at baseline (T0) and at the end of the intervention (T1). The intensive rehabilitation will consist of physiotherapy sessions twice a day and hydrotherapy and virtual reality gait training once a day. The isokinetic training group will have a total of 9 supervised isokinetic strength training sessions focusing on knee flexors and extensors with different execution speeds.

Results
The protocol has been accepted by the French National Ethics Committee in October 2022. The inclusion of patients will start in November 2022.

Conclusions
The combination of intensive rehabilitation with an isokinetic program on knee flexors and extensors has not been studied yet. The findings of this study may determine if an isokinetic strength training program of knee flexors and extensors is beneficial for the improvement of gait parameters, muscle strength, spasticity, and joint position sense in adolescents with spastic diplegia.

International Registered Report Identifier (IRRID)
PRR1-10.2196/43221
Motivation of Farmers in The Corporate Farming Program in Gapoktan Sidomulyo Kapanewon Godean Sleman Regency
Authors: Rahmawati Fitri Laela , Raya Alia Bihrajihant , Harsoyo Harsoyo , Widhiningsih Diah Fitria 
Published: December 2022

Corporate Farming is a program that establishes farmer economic institutions with legal entities in the form of cooperatives or others to encourage the empowerment of agricultural institutions in overcoming farming problems. With the new program issued by the government, hopefully, farmers have the motivation to participate and implement the program to improve the welfare of farming businesses. The aims of this study are: 1) to portray the level of motivation of farmers in participating in the corporate farming program at the Sidomulyo Farmers Association (Gapoktan) in Sidomulyo Urban Village, Kapanewon Godean, Sleman Regency; 2) to comprehend the factors that influence the motivation of farmers in participating in the corporate farming program at the Sidomulyo Farmers' Association in Sidomulyo Urban Village Kapanewon Godean, Sleman Regency. The research applies a descriptive method with a quantitative approach. The combined sampling of farmer groups is carried out by purposive sampling, namely the Sidomulyo Farmer Group Association. Furthermore, the research respondents are selected by simple random sampling on all members of the Farmer Group Association who participated in the corporate farming program. So, the total respondents are 40 farmers. The analysis in this study uses the proportion test and multiple linear regression. The results show that most farmers (more than 50%) in Gapoktan Sidomulyo have a high level of motivation to take part in the program. The factors that significantly influence the motivation of farmers to participate in the corporate farming program are the role of Gapoktan and the accomplishment of the corporate farming program. The factors that have no significant impact on the motivation of farmers to participate in the program are the level of education, land area, farm income, and the number of dependents of the family.
Lexical System of Pinega Dialects
Authors: Levichkin Alexander , Gaidamashko Roman , Krylova Olga 
Published: December 2022

This article presents the findings of the Lexical System of Pinega Dialects project implemented by a team of authors at the Institute for Linguistic Studies of the Russian Academy of Sciences.
The study of Russian dialects remains a topical issue. New dialect dictionaries continue to appear, presenting the vocabularies of Russian dialects recorded in the past and present but not yet lexicographically described.
Modern dialects are an important source of language history information. Furthermore, different dialects may reflect language evolution in different ways. This description of dialects of the Pinega area adds to our understanding of Linguistics and dialect studies in particular. These dialects are an intriguing research target due to their peripheral geographical location and language contacts with Finno-Ugric languages.
The release of Pinega Dialect Dictionary will help clarify certain issues and aid compiling other similar dictionaries.
Digital Technologies in the Development of Russian Speaking Skills and Social and Cultural Competences in Bilingual Children in Russia and Abroad
Authors: Sadykova Gulnara , Kayumova Albina 
Published: December 2022

The research uses the methods of triadic scaffold protocol, case study, survey, interviewing, and observation. The researchers created and tested the first ever model for the development of Russian speaking skills and social and cultural competences in children aged 3 to 8 living in the multilingual regions of Russia and abroad using digital educational tools, as well as the general principles for the integration of digital tools into preschool speech development programs.
Rapid digitization of education and society in general make this work extremely important. Research findings can be recommended for consideration by methodologists, teachers, and parents interested in the development of competencies related to understanding early bilingual development mechanisms, the peculiarities of the generation of digital natives, the criteria for assessing digital resources for preschool and elementary school children’s speech development, scenarios of digital resource integration into family and formal (mass) education, as well as pedagogical strategies for taking advantage of multimodality, interactivity, and gamification offered by digital teaching tools.
Planeación estratégica para impulsar el desarrollo sustentable y la superación de pobreza. Estudio de caso
Authors: García Rodríguez José Félix , Izquierdo Balcázar Naaman , Armenta Ramírez Aída Beatriz , Martínez Pérez Lenin , Pineda Zelaya Lourdes Del Carmen 
Published: December 2022

En México y los países de América Latina y el Caribe es necesario impulsar el desarrollo sustentable y enfrentar los problemas de pobreza y desigualdad presentes en buena parte de su territorio, sobre todo en el área rural. La planeación estratégica aplicada representa una alternativa viable para impulsar el desarrollo endógeno de regiones y comunidades en situación de pobreza. Objetivo: Establecer la importancia de la planeación estratégica para el desarrollo local sustentable de regiones y comunidades en situación de pobreza. Método: investigación cuantitativa, descriptiva y transversal desarrollada en una comunidad en pobreza extrema del sureste de México, con una población de 500 familias. Se determinó una muestra representativa de 90 hogares, a los cuales se aplicó un cuestionario estructurado a partir de los objetivos de investigación, así como de otros estudios relacionados. Resultados. Se identificaron los factores determinantes de la situación de pobreza y marginación en la localidad estudiada, así como las fortalezas y potencialidades para el desarrollo local, estableciéndose así los elementos centrales de un plan estratégico para el desarrollo sustentable de regiones y comunidades en situación de pobreza.
Comprender la violencia para detener la violencia. Demandas sociales frente al reto de la paz total
Authors: Salas Salazar Vicente Fernando , Rivas Osorio Pedro Pablo 
Published: December 2022

Se presenta a continuación una reflexión teórica y metodológica que conduce a pensar la violencia desde diferentes perspectivas. Es decir, se avanza hacia la consideración de elementos que van desde la agresión directa, que tipifica un comportamiento violento, hasta considerar las causas estructurales que lo desencadenan, necesidades básicas insatisfechas, desigualdad social, escasas oportunidades de ascenso y movilidad social y reproducción de formas de ser, actuar y sentir que se internalizan como pautas culturales y se normalizan en los contextos donde hacen carrera las demandas estructurales.
El encuadre analítico se soporta en las investigaciones de Johan Galtung, para reconocer las tres dimensiones de la violencia (física, estructural y cultural) nosdetenemos en el caso colombiano, e incorporamos los serios aportes de Norbert Elías respecto de la relación individuo y sociedad como acontecimientos que se interrelacionan y se determinan mutuamente. Llevamos la idea de condición civilizatoria de Elías y la acoplamos con el concepto de socialidad en Maffesoli para llegar al potente concepto de habitus en Bourdieu. Este encuadre analítico nos va a permitir comprender el fenómeno de la violencia en sus tres dimensiones y que, acompañado de algunas sendas investigaciones en el contexto nacional y latinoamericano, nos permite inferir los retos y desafíos para una idea de paz total desde el escenario de la dimensión cultural de la violencia.
Diabetes, Atherosclerosis, and Stenosis by AI
Authors: Jonas Rebecca A. , Crabtree Tami R. , Jennings Robert S. , Marques Hugo , Katz Richard J. , Chang Hyuk-Jae , Stuijfzand Wijnand J. , van Rosendael Alexander R. , Choi Jung Hyun , Doh Joon-Hyung , Her Ae-Young , Koo Bon-Kwon , Nam Chang-Wook , Park Hyung-Bok , Shin Sang-Hoon , Cole Jason , Gimelli Alessia , Khan Muhammad Akram , Lu Bin , Gao Yang , Nabi Faisal , Nakazato Ryo , Schoepf U. Joseph , Driessen Roel S. , Bom Michiel J. , Thompson Randall C. , Jang James J. , Ridner Michael , Rowan Chris , Avelar Erick , Généreux Philippe , Knaapen Paul , de Waard Guus A. , Pontone Gianluca , Andreini Daniele , Al-Mallah Mouaz H. , Guglielmo Marco , Bax Jeroen J. , Earls James P. , Min James K. , Choi Andrew D. , Villines Todd C. 
Published: December 2022

OBJECTIVE
This study evaluates the relationship between atherosclerotic plaque characteristics (APCs) and angiographic stenosis severity in patients with and without diabetes. Whether APCs differ based on lesion severity and diabetes status is unknown.

RESEARCH DESIGN AND METHODS
We retrospectively evaluated 303 subjects from the Computed TomogRaphic Evaluation of Atherosclerotic Determinants of Myocardial IsChEmia (CREDENCE) trial referred for invasive coronary angiography with coronary computed tomographic angiography (CCTA) and classified lesions as obstructive (≥50% stenosed) or nonobstructive using blinded core laboratory analysis of quantitative coronary angiography. CCTA quantified APCs, including plaque volume (PV), calcified plaque (CP), noncalcified plaque (NCP), low-density NCP (LD-NCP), lesion length, positive remodeling (PR), high-risk plaque (HRP), and percentage of atheroma volume (PAV; PV normalized for vessel volume). The relationship between APCs, stenosis severity, and diabetes status was assessed.

RESULTS
Among the 303 patients, 95 (31.4%) had diabetes. There were 117 lesions in the cohort with diabetes, 58.1% of which were obstructive. Patients with diabetes had greater plaque burden (P = 0.004). Patients with diabetes and nonobstructive disease had greater PV (P = 0.02), PAV (P = 0.02), NCP (P = 0.03), PAV NCP (P = 0.02), diseased vessels (P = 0.03), and maximum stenosis (P = 0.02) than patients without diabetes with nonobstructive disease. APCs were similar between patients with diabetes with nonobstructive disease and patients without diabetes with obstructive disease. Diabetes status did not affect HRP or PR. Patients with diabetes had similar APCs in obstructive and nonobstructive lesions.

CONCLUSIONS
Patients with diabetes and nonobstructive stenosis had an association to similar APCs as patients without diabetes who had obstructive stenosis. Among patients with nonobstructive disease, patients with diabetes had more total PV and NCP.
Circulating small non-coding RNA profiling as potential biomarkers of atherosclerotic plaque composition in Type 1 diabetes
Authors: Giannella Alessandra , Castelblanco Esmeralda , Zambon Carlo Federico , Basso Daniela , Hernandez Marta , Ortega Emilio , Alonso Nuria , Mauricio Didac , Avogaro Angelo , Ceolotto Giulio , Kreutzenberg Saula Vigili de 
Published: December 2022

<p> </p>
<p><strong>OBJECTIVE</strong></p>
<p>Cardiovascular disease (CVD) accounts for most deaths in patients with type 1 diabetes (T1D); however, the determinants of plaque composition are unknown. MicroRNAs (miRNAs) regulate gene expression, participate in the development of atherosclerosis and represent promising CVD biomarkers. This study analyzed the circulating miRNA expression profile in T1D with carotid either calcified (CCP) or fibrous (CFP) plaque. </p>
<p><strong>RESEARCH DESIGN AND METHODS</strong></p>
<p>Circulating small non-coding RNA were sequenced and quantified using NGS and bioinformatic analysis in an exploratory set of 26 T1D with CCP and in 25 with CFP. Then, in a validation set of 40 CCP, 40 CFP and 24 controls T1D, selected miRNAs expression was measured by digital droplet PCR. Putative gene targets enriched for pathways implicated in atherosclerosis/vascular calcification/diabetes were analyzed. Patient’s main clinical characteristics were also recorded.</p>
<p><strong>RESULTS</strong></p>
<p>miR-503-5p, let-7d-5p, miR-106b-3p, miR-93-5p were significantly up-regulated, while miR-10a-5p downregulated in CCP patients compared to CFP (all FC>±1.5, p<0.05). All candidate miRNAs showed a significant correlation with LDL-cholesterol, direct for the up-regulated and inverse for the downregulated one, in CCP. Many target genes of up-regulated miRNAs in CCP participate in osteogenic differentiation, apoptosis, inflammation, cholesterol metabolism, and extracellular matrix organization.</p>
<p><strong>CONCLUSIONS</strong></p>
<p>These findings characterize miRNAs and their signature in the regulatory network of carotid plaque phenotype, in T1D, providing new insights into plaque pathophysiology, and possibly novel biomarkers of plaque composition.</p>
Two-year follow up from the T1GER study: Continued off-therapy metabolic improvements in children and young adults with new onset T1D treated with golimumab and characterization of responders
Authors: Rigby Mark , Hayes Beverly , Liu Yinglei , Vercruysse Frank , Hedrick Joseph A. , Quattrin Teresa 
Published: December 2022

<p> </p>
<p><strong>OBJECTIVE.</strong> The T1GER study showed many metabolic benefits of the TNF-α blocker golimumab in children and young adults with Type 1 diabetes (T1D). Off therapy effects are reported. </p>
<p><strong>RESEARCH DESIGNS AND METHODS.</strong> T1GER was a Phase 2, placebo-controlled randomized trial in which golimumab or placebo was administered for 52 weeks to participants 6-21 years old diagnosed with T1D diagnosed within 100 days. Assessments occurred during the 52-week on-therapy and 52-week off-therapy periods. </p>
<p><strong>RESULTS.</strong> After stopping treatment, C-peptide AUCs remained greater in the treatment versus control group. At Weeks 78 and 104 the golimumab group had lower reductions in 4h C-peptide AUC from baseline where the golimumab groups had reductions of 0.31 and 0.41 nmol/L, while the placebo group had reductions of 0.64 and 0.74 nmol/L. There were also trends in less insulin use, higher peak C-peptide levels and those in partial remission and higher peak C-peptide levels in the golimumab group. Golimumab responders, defined as having an increase or minimal loss of C-peptide AUC and/or being in partial remission at Week 52, showed even greater improvements in most metabolic parameters on and off therapy and had less hypoglycemia during the off-therapy period versus placebo. Adverse events, including infections, were similar between the groups during all time periods of the study.</p>
<p><strong>CONCLUSIONS.</strong> In children and young adults with new onset T1D, golimumab preserved endogenous beta cell function and resulted in other favorable metabolic parameters on and off therapy. A subpopulation had disease stabilization while on-therapy with improved metabolic parameters off therapy.</p>
Patient–surgeon sex discordance impacts adverse events but does not affect patient-reported satisfaction after primary total hip arthroplasty: a regional register-based cohort study
Authors: Jolbäck Per , Mukka Sebastian , Wetterling Kristin , Mohaddes Maizar , Garland Anne 
Published: December 2022

Background and purpose: The sex of the surgeon has been proposed to be associated with a disparity in clinical outcomes after different surgical procedures. We investigated the association between surgeon–patient sex discordance and adverse events (AEs) and surgical AEs (SAEs) within 90 days after primary total hip arthroplasty (THA). We also investigated patient-reported satisfaction with surgical outcomes 1 year after the surgery.Patients and methods: We conducted a register-based cohort study including primary THAs performed due to osteoarthritis between 2008 and 2016 at 10 publicly managed hospitals in western Sweden. Hospital data was linked to the Swedish Arthroplasty Register and a regional patient register. Logistic regression models investigated discordant sex of patients and surgeons on AEs/SAEs and patient-reported satisfaction with the surgical outcome.Results: 11,993 primary THAs were included in the study. The proportion of AEs for the concordant group was 7.3% and for the discordant group 6.1%. For SAEs, the proportion was 5.0% for the concordant group and 4.3% for the discordant group. After adjustment the discordant group still had a lower likelihood of an AE or SAE than the concordant group: adjusted odds ratio (aOR) for AE (0.82, 95%CI 0.71–0.95) and for SAE (0.86, CI 0.72–0.99). No association was detected between patient-reported satisfaction and sex discordance.Conclusion: Sex discordance between surgeons and patients is linked to a decreased risk of an AE but not a lower level of patient-reported satisfaction with the surgical outcome.
Peran Unit Usaha Kampung Marketer Dalam Mengatasi Pengangguran Dan Urbanisasi Untuk Membentuk Ketahanan Pribadi Pemuda Desa Tamansari, Kecamatan Karangmoncol, Kabupaten Purbalingga, Provinsi Jawa Tengah
Authors: Wijaya Placenta Abshar , Suprihanto John , Riyono Bagus 
Published: December 2022

The aims of this research include: (1) To analyze the role of the business unit of the Kampung Marketer (Marketer Village) in managing the unemployment and urbanization among the youths in Tamansari Village, Karangmoncol District, Purbalingga Regency, Central Java Province; (2) To evaluate the impacts of the business unit of a Kampung Marketer in building the personal resilience among the youths in Tamansari Village, Karangmoncol District, Purbalingga Regency, Central Java Province. This is a descriptive-qualitative research. The technique in collecting data in this research was conducted through interview, observation, documentation and searching online data. The analysis tool in this research used the descriptive-qualitative analysis and comparative analysis.The results of this research showed that: (1) there were a number of roles of the Business Unit of Kampung Marketer in managing the unemployment and urbanization among the youths in Tamansari Village, Karangmoncol District, Purbalingga Regency, Central Java Province, namely creating massive employment opportunities for youth in the village and of course providing the ability for young people to be self-employed; (2) There was an impact on the role of Business Unit of Kampung Marketer on the personal resilience building among the youths of Tamansari Village, Karangmoncol District, Purbalingga Regency, Central Java Province, i.e. in the aspects of self-confidence, responsibility, togetherness, independence, adhering to principles, and perseverance.
RENCANA AKSI DAERAH KABUPATEN TULANG BAWANG DALAM MEMENUHI 100% AKSES AIR MINUM DAN PENYEHATAN LINGKUNGAN (RAD AMPL)
Authors: Nurcholis Nurcholis , Darmayanti Euis 
Published: December 2022

Sesuai dengan Amanat yang tercantum dalam RPJMN 2020 – 2024, Pemerintah Indonesia menargetkan dapat menyediakan layanan air minum yang aman dan sanitasi yang layak bagi seluruh rakyat Indonesia. Secara nasional sampai dengan akhir tahun 2019 (susenas BPS 2019 ), akses air minum yang aman baru tersedia bagi 89,27% dari total penduduk Indonesia, sedangkan untuk kebutuhan sanitasi dasar baru mencapai 77,44% dari total penduduk Indonesia. Hasil analisis menunjukkan bahwa untuk investasi sanitasi dihitung dengan menggunakan pendekatan berbasis masyarakat, baik di perkotaan maupun di perdesaan dengan asumsi biaya investasi per Kepala Keluarga sebesar Rp. 600.000,- dimana berdasarkan rata-rata jumlah jiwa per KK untuk Kabupaten Tulang Bawang berkisar sekitar 4 org/KK. Maka biaya investasi per jiwa diasumsikan sebesar Rp. 150.000,-.Analisis lebih lanjut dapat disimpulkan bahwa berdasarkan capaian kinerja AMPL Kabupaten Tulang Bawang sampai dengan tahun 2020, target pencapaian bidang air minum dan sanitasi, pada akhir 2026 Kabupaten diharapkan mampu mencapai kondisi 100 % penduduk memiliki akses air minum layak dan aman serta 100% penduduk memiliki akses sanitasi layak sesuai dengan target SDGs Tahun 2024. Untuk mencapai kondisi tersebut, diperkirakan kebutuhan investasi sampai 2026 untuk air minum adalah Rp. 38.587.700.000,- dan untuk sanitasi adalah Rp 13.130.250.000,-. Dengan demikian kebutuhan investasi air minum dan sanitasi sampai 2026 mencapai Rp. 51.717.950.000,- atau dalam periode 5 tahun membutuhkan investasi sebesar Rp. 10.343.590.000,- per tahun .