bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Cytotoxic and Anti-tumor Potential of Methanolic Extracts of Indian Marine
Isolates in HCT116 Colorectal Cancer Cells
Authors: A Shahjahan , Sekar Sruthi , Kasinathan Kumaran , KN ArulJothi 
Published: August 2023

Introduction:
The marine environment is a rich source of biodiversity, with several of its inhabitants producing
unique and physiologically active substances. The use of marine bacterial-derived chemicals over traditional
pharmaceuticals is gaining traction due to their larger variety of targets and modes of action. To circumvent the drawbacks
of current therapy options, researchers have looked to marine microbes for novel and effective anti-cancer compounds.
In this study, we examine one of India's least-examined coastal areas in search of novel bacterial sources of
anti-cancer chemicals.

Methods:
Soil sediments from the Indian south coast region were collected and microbes were isolated using standard
methods. The microorganisms were identified using 16s rRNA sequencing, and cytotoxic extracts were further examined
using GC-MS. MTT, clonogenic, and spheroid tests assessed the extract's cytotoxicity and anti-tumor efficacy.

Results:
Our results indicated that the bacterial isolates with potent cytotoxic activity were Bacillus drentensis and
Bacillus haikouensis and had 10 and 12 potent anti-cancer and other bioactive compounds. The extracts had an IC50 of
30.08 and 109.4 μg/ml in the HCT116 cell line, respectively, and strongly inhibited colony formation. The cell cycle
analysis indicated that the extract induced cell death as indicated by the subG0 peak. We also showed that these methanolic
extracts induced toxicity in a 3D spheroid model indicating a strong anti-tumor activity. Furthermore, we performed
molecular docking for the compounds present in the extracts to VEGFR and nucleolin and found that ergostane
had favorable binding energy only to VEGFR.

Conclusion:
The results indicate that the ME of B. drentensis and B. haikouensis contains potent anti-cancer compounds
to exhibit cytotoxic and anti-tumor activity in colorectal cancer cells.
Formulation and Development of Clove and Coriander Combination
Herbal Dental Anticaries Gel and Evaluation of its Antimicrobial Activity
Authors: Paramita Ganguly , Julekha Kazi , Kumar Mandal Sudip 
Published: August 2023

Background::
Dental caries is one of the Periodontal diseases that has been recognized
as a major public health problem for decades throughout the world. It occurs in all groups, ethnicities,
races, and genders at all socioeconomic levels. Natural remedies are more acceptable in the belief
that they are safer with fewer side effects than synthetic ones. Clove and coriander oil are established
herbal drugs for periodontal diseases.

Objective::
This research work was intended to formulate a dental gel containing clove and Coriander
as the major constituents and evaluate it for dental caries treatment. Both of the herbal oils have
a vast range of antimicrobial activity against a great number of periodontal pathogens; therefore,
they are used for periodontitis treatment.

Methods::
The combination gel was prepared using carbopol 934 as a gelling agent, clove oil and
coriander oil as therapeutic constituents, polyethylene glycol as a co-solvent, methyl paraben and
propyl paraben as a preservative and a required quantity of distilled water as vehicle.

Results::
The gel was analyzed for various properties like antimicrobial activity, pH, spreadability,
extrudability, drug content etc., and it was shown that the combination gel is a satisfactory dosage
form that is used in periodontitis treatment. The combination gel revealed the ZI (zone of inhibition)
of about 22.05±0.04 mm.

Conclusion::
The present study concluded that the combination gel preparations of clove oil and coriander
oil reported satisfactory physicochemical properties along with good drug content compared
to the single gel preparation.
Pharmacognostical, Physicochemical Evaluation, and In Vitro Anti-obesity Investigation of Citrullus colocynthis Linn. Fruits from Western Haryana
Authors: Dahiya Vinesh , Vasudeva Neeru , Sharma Sunil , Kumar Ashok 
Published: August 2023

Background:
Cucurbitaceae family plants have been widely used as traditional medicines for the prevention and treatment of many ailments. Citrullus colocynthis Linnaeus also known as Colocynth, is a bitter plant commonly found growing in sandy deserts around the world, and it grows naturally in the Western Haryana region. Fruits of this plant have been utilized traditionally for various medicinal purposes, like as an appetite suppressant, hypoglycemic, diuretic, laxative, anthelmintic, and for treating renal stones.

Objective:
The objective of this study is to carry out the in vitro anti-obesity investigation, pharmacognostical studies, heavy metal and pesticide residue analysis, microbial contamination, and mycotoxins evaluation of the Citrullus colocynthis fruits for establishing their quality, safety, efficacy, and purity standards.

Methods:
Fresh fruits were collected and taxonomically authenticated. The pharmacognostical characteristics of the intact and powdered fruits were identified and qualitative and quantitative phytochemical evaluation was performed. Physicochemical evaluation, heavy metal and pesticide residue detection, microbial contamination, and mycotoxins analysis were performed as per WHO guidelines 2011. In vitro inhibition activities for pancreatic lipase and α-amylase enzymes were carried out as per standard procedures and IC50 values were recorded.

Results:
The pharmacognostical standards viz. macroscopy, microscopy and physicochemical parameters were laid, and the drug was declared free from microbial contamination and mycotoxins. Heavy metal analysis and pesticide residue detection revealed that their presence was below toxic levels. The Powder microscopy, microbial contamination, mycotoxin evaluation, and pesticide residue of the Colocynth fruits are novel findings. The IC50 values (µg/ml) for pancreatic lipase inhibition for aqueous and ethanolic extracts were found to be 21.27±1.25 and 34.35±1.86, and for α-glucosidase, the values were 271.12±2.64 and 283.21±3.06, and for α-glucosidase, the values were 295.67±2.92 and 306.15±3.44 respectively. Thus, the fruit extracts showed significant in vitro anti-obesity potential.

Conclusion:
Pharmacognostical and physicochemical studies prove to be useful in reducing commercial adulteration of the crude drug by assuring their purity and identity and this could further help in improving the quality of formulations incorporating it. The results of various standardization parameters could be used for designing the monograph of the crude drug. The fruits were found to be fit for therapeutic consumption and their extracts have shown good pancreatic lipase inhibition. The in vitro anti-obesity investigation findings of the fruit extracts can further be explored in-vivo for evaluating their therapeutic efficacy.
Identifying the Most Effective Recruitment Strategy Using Financial Reimbursements for a Web-Based Peer Network Study With Young People Aged 16-18 Years: Protocol for a Randomized Controlled Trial
Authors: Raggatt Michelle , Wright Cassandra J C , Sacks-Davis Rachel , Dietze Paul M , Hellard Margaret E , Hocking Jane S , Lim Megan S C 
Published: August 2023

Background
Peers are an important determinant of health and well-being during late adolescence; however, there is limited quantitative research examining peer influence. Previous peer network research with adolescents faced methodological limitations and difficulties recruiting young people.

Objective
This study aims to determine whether a web-based peer network survey is effective at recruiting adolescent peer networks by comparing 2 strategies for reimbursement.

Methods
This study will use a 2-group randomized trial design to test the effectiveness of reimbursements for peer referral in a web-based cross-sectional peer network survey. Young people aged 16-18 years recruited through Instagram, Snapchat, and a survey panel will be randomized to receive either scaled group reimbursement (the experimental group) or fixed individual reimbursement (the control group). All participants will receive a reimbursement of Aus $5 (US $3.70) for their own survey completion. In the experimental group (scaled group reimbursement), all participants within a peer network will receive an additional Aus $5 (US $3.70) voucher for each referred participant who completes the study, up to a maximum total value of Aus $30 (US $22.20) per participant. In the control group (fixed individual reimbursement), participants will only be reimbursed for their own survey completion. Participants’ peer networks are assessed during the survey by asking about their close friends. A unique survey link will be generated to share with the participant’s nominated friends for the recruitment of secondary participants. Outcomes are the proportion of a participant’s peer network and the number of referred peers who complete the survey. The required sample size is 306 primary participants. Using a multilevel logistic regression model, we will assess the effect of the reimbursement intervention on the proportion of primary participants’ close friends who complete the survey. The secondary aim is to determine participant characteristics that are associated with successfully recruiting close friends. Young people aged 16-18 years were involved in the development of the study design through focus groups and interviews (n=26).

Results
Participant recruitment commenced in 2022.

Conclusions
A longitudinal web-based social network study could provide important data on how social networks and their influence change over time. This trial aims to determine whether scaled group reimbursement can increase the number of peers referred. The outcomes of this trial will improve the recruitment of young people to web-based network studies of sensitive health issues.

International Registered Report Identifier (IRRID)
DERR1-10.2196/44813
THE ROLE OF THE SCHOOL HEAD IN THE SELF-DEVELOPMENT OF STUDENTS THROUGH EXTRACULAR ACTIVITIES (CASE STUDY MIN 1 BENER MERIAH)
Authors: Mirela Tiarani , Na'imah Na'imah , Lailatussaadah Lailatussaadah 
Published: August 2023

The purpose of this study was to describe why the role of the principal in self-development of students through extracurricular activities at MIN 1 Bener Meriah, and to describe the role of the principal in self-development of students through extracurricular activities at MIN 1 Bener Meriah. This study is a qualitative type using observational, interviews and documentation, data analysis using triangulation theory. Based on the results of the research: the role of the principal is very important in the self-development of students at MIN 1 Bener Meriah. Among these roles are (1) educator: teaching with teacher intermediaries, (2) manager: managing with POAC even though the field is narrow, (3) administrators: take care of correspondence and funding for extracurricular activities, (4) supervise extracurricular activities through joint meetings and direct involvement, (5) leaders: mobilize involved teachers and students in extracurricular activities, (6) innovator: Principals make reforms such as creative guel dance (7) motivator: the principal provides encouragement in the form of words and gifts for students who excel, including in extracurricular activities. So that the role of the principal is done well, it will also have a good impact on the development of students in the extracurricular program.
Retos y soluciones para SISPRO en Colombia
Authors: Toloza Pérez Yesith Guillermo 
Published: August 2023

Quisiera contribuir a la discusión sobre la utilización de las bases de datos disponibles en el Sistema Integrado de Información de la Protección Social (Sispro), en el caso específico de las variables costo neto a pagar, referidas en el artículo “Sispro: la base de datos administrativa del sistema de salud colombiano” (1), en el cual los autores señalan que “el costo total de las atenciones en salud del quinquenio de 2017 a 2021 fue de 8.377 billones de pesos (lo que equivaldría a 271 millones de pesos por persona atendida), cifra que supera el PIB de Colombia que para 2021 fue de 314,3 billones según el DANE”. Esto se debe a que el flujo de información de dichas variables, es reportado por los prestadores de servicios de salud con información de los registros individuales de prestación de servicios de salud (RIPS). Asimismo, los autores destacan que la remisión de la información de RIPS no tiene restricciones o validación por parte de Sispro; dicha información no está definida en la Resolución 3374 del 2000, por tanto, los prestadores pueden reportar sus atenciones en cualquier periodo, sin controlar valores máximos o mínimos, lo que puede ocasionar una supra o infravaloración del costo real, por lo cual esta medida pierde validez.
Los RIPS proporcionan los datos mínimos y básicos necesarios para hacer seguimiento al Sistema de Prestaciones de Salud en el Sistema General de Seguridad Social en Salud (SGSSS), específicamente en relación con el paquete obligatorio de servicios (POS y POSS). Además, el objetivo del registro es facilitar las relaciones comerciales entre las entidades administradoras (pagadores) y las instituciones y los profesionales independientes (prestadores), mediante la presentación del detalle de la factura de venta de servicios en formato digital, con una estructura estándar que simplifica la comunicación y los procesos de transferencia y revisión de datos, con independencia del software utilizado por los prestadores.
Forecasting COVID-19 Cases in Indonesia, Malaysia, Philippines, and Vietnam Using ARIMA and LSTM
Authors: Paedah Marina Wahyuni , Gunawan Fergyanto E. 
Published: August 2023

COVID-19 has severely impacted the global economy, including ASEAN countries. Various plans and strategies are still needed during the pandemic-to-epidemic transition period to minimize the risk of COVID-19 transmission. The research focuses on the total number of confirmed cases of COVID-19 in Indonesia, Malaysia, the Philippines, and Vietnam, which are among the ASEAN countries with the highest number of cases in Southeast Asia. Those countries have cultural similarities, where gathering with friends and family is an important part of social life. This research evaluates the ability of ARIMA and LSTM to predict COVID-19 cases in each country, using daily data from January 23, 2020 to October 22, 2022. Datasets published by Johns Hopkins University (JHU) and Our World in Data (OWID) are used, which are accessible through Github. Compared to ARIMA with R2 of 0,8883 for Indonesia, 0,8353 for Malaysia, 0.97291 for the Philippines, and -3.105 for Vietnam, LSTM model can predict better in the four sampled ASEAN countries, with an R2 of 0.9996 for Indonesia, 0.9707 for Malaysia, 0.97291 for the Philippines, and 0.9200 for Vietnam.
Information Center Chatbot in Higher Education Using Dialogflow
Authors: Isnafirlah Dais , Kamayani Mia 
Published: August 2023

Fakultas Teknologi Industri dan Informatika UHAMKA, memiliki website resmi yang mengacu pada sistem informasi universitas yang berfungsi untuk pelayanan yang efektif dan menggunakan teknologi terkini. Faktanya, masih memiliki beberapa permasalahan yang terjadi yaitu dosen dan mahasiswa masih sering bertanya via japri ke pihak sekretariat, akademik maupun pimpinan prodi dan fakultas jika memerlukan informasi, serta masih sering melewatkan informasi yang ada di broadcast Grup WhatsApp. Oleh karena itu, tujuan dari penelitian ini untuk merencanakan dan menerapkan teknologi chatbot yang memberikan mahasiswa akses informasi yang cepat dan mudah tentang akademik Fakultas Teknologi Industri dan Informatika UHAMKA secara mudah dan cepat. Chatbot ini diimplementasikan menggunakan tools Dialogflow dengan metode Prototype dan Telegram API. Setelah melakukan uji coba blackbox, Bot Telegram yang dibuat telah terbukti mampu memberikan respons yang memuaskan terhadap pertanyaan yang diajukan, sehingga dapat memberikan bantuan kepada user dalam memperoleh informasi akademik yang dibutuhkan. Selain itu, pengguna tidak perlu menunggu terlalu lama untuk menerima balasan dari chatbot, sehingga membuat chatbot yang digunakan dapat beroperasi dengan cepat dan tepat.The UHAMKA Faculty of Industrial and Informatics Technology has an official website that refers to a university information system that functions for effective service and uses the latest technology. In fact, there are still several problems that occur, namely lecturers and students still often ask via email to the secretariat, academics or study program and faculty leaders if they need information, and they still often miss information that is WhatsApp Group. Therefore, the purpose of this research is to plan and implement chatbot technology that gives students quick and easy access to information about the academics of the Faculty of Industrial Technology and Informatics UHAMKA easily and quickly. This chatbot is implemented using Dialogflow tools with the Prototype method and the Telegram API. After conducting a blackbox trial, the Telegram Bot that was created has been proven to be able to provide a satisfactory response to the questions asked, so that it can provide assistance to users in obtaining the required academic information. In addition, users don't have to wait too long to receive a reply from the chatbot, so that the chatbot used can operate quickly and precisely.
Design of an Integrated Medical Record Information System at Puskesmas Kota Banjar
Authors: Shofa Rahmi Nur , Rachman Andi Nur , Ramdani Cecep Muhamad Sidik , Dewi Euis Nur Fitriani 
Published: August 2023

Perkembangan pemanfaatan ilmu pengetahuan dan teknologi memberikan dampak yang dapat digunakan diberbagai bidang salah satunya Puskesmas. Salah satu pengembangan yang dilakukan puskesmas yaitu mengembangkan untuk meningkatkan kualitas manajemen pelayanan kesehatan dengan menerapkan sistem informasi puskesmas berbasis teknologi informasi. Pencatatan apabila dilakukan dengan cara ditulis pada buku pasien merupakan cara lama yang digunakan. Maka perlu adanya suatu sistem yang membantu untuk memudahkan pencatatan. Metode pengembangan pada sistem informasi yang akan di ajukan ini yaitu dengan metode Waterfall. Menghasilkan Sistem Informasi Rekam Medis yang terintegrasi untuk mempermudah pihak Puskesmas di daerah Kota Banjar dalam mengolah data jika terdapat pasien yang sebelumnya belum pernah mengunjungi puskesmas tersebut maka akan terdapat Rekam Medis. Sistem Informasi mempermudah dalam mengelola data Rekam Medis sehingga tidak perlu mencari catatan yang begitu banyak dikarenakan data nya sudah tersimpan dalam database. Sistem Informasi Rekam Medis terintegrasi maka data pasien akan terlihat di semua Puskesmas yang ada di Kota Banjar. Pengujian dalam penelitian dilakukan dengan tahapan metode System Usability Scale (SUS) mendapat nilai akhir yaitu 73,1 dan Hasil pengujian menghasilkan nilai rekomendasi dalam kategori Acceptable.The development of the use of science and technology has an impact that can be used in various fields, one of which is the Puskesmas. One of the developments carried out by the puskesmas is developing to improve the quality of health service management by implementing an information technology-based puskesmas information system. Recording when it is done by writing it in the patient book is the old way used. So, it is necessary to have a system that helps to facilitate recording. The development method for the information system that will be proposed is the Waterfall method. Producing an integrated Medical Record Information System to make it easier for the Puskesmas in the Banjar City area to process data. If there are patients who have never visited the puskesmas before, there will be Medical Records. The Information System makes it easy to manage Medical Record data so there is no need to search for so many records because the data is already stored in the database. The Medical Record Information System is integrated so that patient data will be visible in all Community Health Centers in Banjar City. Testing in the study was carried out using the System Usability Scale (SUS) method, obtaining a final score of 73.1 and the test results yielded a recommendation value in the Acceptable category.
Gapformer: Graph Transformer with Graph Pooling for Node Classification
Authors: Liu Chuang , Zhan Yibing , Ma Xueqi , Ding Liang , Tao Dapeng , Wu Jia , Hu Wenbin 
Published: August 2023

Graph Transformers (GTs) have proved their advantage in graph-level tasks. However, existing GTs still perform unsatisfactorily on the node classification task due to 1) the overwhelming unrelated information obtained from a vast number of irrelevant distant nodes and 2) the quadratic complexity regarding the number of nodes via the fully connected attention mechanism. In this paper, we present Gapformer, a method for node classification that deeply incorporates Graph Transformer with Graph Pooling. More specifically, Gapformer coarsens the large-scale nodes of a graph into a smaller number of pooling nodes via local or global graph pooling methods, and then computes the attention solely with the pooling nodes rather than all other nodes. In such a manner, the negative influence of the overwhelming unrelated nodes is mitigated while maintaining the long-range information, and the quadratic complexity is reduced to linear complexity with respect to the fixed number of pooling nodes. Extensive experiments on 13 node classification datasets, including homophilic and heterophilic graph datasets, demonstrate the competitive performance of Gapformer over existing Graph Neural Networks and GTs.
Liquid Oxygen/Gaseous Methane Single-Element Shear Coaxial Flame Dynamics
Authors: Roa Mario , Talley Douglas G. , Munipalli Ramakanth 
Published: August 2023

An experimental study was conducted to visualize the dynamics and spectra of single-element shear coaxial liquid oxygen (LOX)/gaseous methane flames at high but still subcritical pressure for the LOX, and at supercritical temperature for the methane. High-speed shadowgraphs were employed to image and track the flame and jet dynamics close to the liquid oxygen’s post region. High-speed [Formula: see text] and [Formula: see text] chemiluminescence were also simultaneously collected along the same line of sight as the shadowgraphs. The results were compared to previous LOX/hydrogen results using the same injector at the same momentum flux ratios. The initial temperature of the methane was varied between 200 and 300 K. The LOX/methane flames were found to share many features in common with the LOX/hydrogen flames previously studied, but there were notable differences. The spreading rate of the LOX/hydrogen flames was larger than that of LOX/methane flames. The amplitude of the spreading rate fluctuations for hydrogen was also larger, although the relative spreading rate fluctuations normalized by the average spreading rates were about the same. Despite the differences, a wave amplification mechanism found previously to be active for shear coaxial LOX/hydrogen flames was found to also be active for LOX/methane flames. Overall, both the LOX/methane flames and the LOX/hydrogen were both found to be spectrally fairly quiet.