bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efisiensi Agribisnis Padi Sawah pada Tingkat Usahatani di Desa Payalombang Kecamatan Tebing Tinggi Kabupaten Serdang Bedagai Sumatera Utara
Authors: Deras Stefanus , Tarsisia Luju Maria 
Published: April 2023

Usahatani sebagai kegiatan sentral agribisnis padi sawah penting ditingkatkan efisiensinya demi menjaga kontinuitas produksi, kecukupan produksi, pemerataan pendistribusian beras di seluruh wilayah Indonesia. Efisiensi teknis dan harga produksi akan menjadi insentif bagi petani untuk selalu meningkatkan produktivitas usahatani. Masalah penelitian adalah: seberapa besar efisiensi agribisnis pada tingkat usahatani padi sawah, dan apakah penggunaan sarana produksi dalam usahatani berpengaruh signifikan terhadap produksi padi sawah?
Populasi penelitian adalah keluarga petani sebesar 134 kepala keluarga (kk) dan diambil 40 kk sebagai sampel dengan metode “stratified random sampling” berdasarkan luas lahan yang ada. Analisis terhadap data dengan deskriptif dan inferensia statistic dengan model regresi non linear Cobb Douglas. Hasil penelitian menunjukkan bahwa secara parsial benih, jumlah tenaga kerja, pupuk urea, ponska, dan sindax berpengaruh nyata terhadap produksi padi sawah. Penggunaan faktor produksi benih, tenaga kerja, pupuk urea, pupuk phonska dan pestisida sindax sudah efisien, sedangkan pestisida bestox belum efisien, sehingga masih perlu ditambahkan.

Kata kunci: produksi, faktor produksi, efisiensi
Who is Publishing in Biomedical Predatory Journals? A Study on Chinese Scholars
Authors: Wang Jiahao , Yang Cheng , Chen Ming 
Published: April 2023

The scale of predatory journals in the biomedical field is proliferating worldwide. In China, numerous cases of academic misconduct have occurred in international biomedical journals. The study aims to understand the sociodemographic characteristics of Chinese authors publishing in predatory biomedical journals and their perceptions of predatory journals. In predatory biomedical journals, 1408 Chinese scholars with 1482 published papers were identified. A questionnaire on predatory journals was emailed to them to analyse their perceptions of predatory journals. The study finds that provinces and cities with more authors are mainly distributed in eastern and central China. Authors mainly worked in hospitals ( n = 1162, 82.53 per cent) and schools ( n = 246, 17.47 per cent). Among hospitals, forty-eight are currently ranked in the top fifty in China. A total of ninety-three (7 per cent) authors responded to the questionnaire. Only half of the authors knew the concept of predatory journals ( n = 45, 48.39 per cent). Most respondents would not consider choosing predatory journals again ( n = 85, 91.40 per cent). Among all the corresponding authors, doctors working in top Chinese hospitals made up the majority. Chinese authors had insufficient knowledge of predatory journals, although most had professional expertise.
Exploring the moderating effect of coworker support and supervisor support on the relationship between self-efficacy and subjective well-being of academic faculty in Pakistan.
Authors: Sarwar Farhan , Rehman Zia-ur , Azhar Sarah 
Published: April 2023

In recent years academic faculty jobs have undergone significant changes from being low demanding and highly satisfying to stressful and challenging. The ongoing challenge of COVID-19 has intensified the teaching and research challenge of placing academicians' well-being at stake. The current study explores a personality antecedent (self-efficacy) and a contextual antecedent (job social support) of academic faculty subjective well-being measured as job satisfaction and overall satisfaction with life. Data collected from 326 public and private sector faculty was subjected to measurement and structural model analysis using SMART-PLS 3. Hypothesis testing for direct effect revealed that self-efficacy and supervisor social support are significantly related to life satisfaction. Coworker support and supervisor social support are significantly associated with job satisfaction. The moderation analysis revealed that supervisor support positively moderates the relationship between self-efficacy and subjective evaluation of well-being. In contrast, coworker support negatively moderates the relationship between self-efficacy and subjective well-being. The results revealed that although supervisor support is an important determinant of how self-efficacy leads to higher well-being among academicians, a high level of coworker support may negatively affect individuals with high self-efficacy. The study highlights the importance of matching personality with the job's situational factors to improve faculty's well-being.
УПРАВЛІННЯ ВИТРАТАМИ ПІДПРИЄМСТВА: ФУНКЦІОНАЛЬНИЙ АСПЕКТ
Authors: Чумак Ганна 
Published: April 2023

Метою статті є дослідження особливостей управління витратами на підприємстві з метою прийняття ефективних управлінських рішень. Актуальність досліджуваної проблеми зумовлена появою нових наукових концепцій та ідей розвитку суспільства, а також потребою удосконалення існуючих методів управління та їх адаптацією до умов функціонування підприємств України. В умовах ринкової економіки основна мета діяльності підприємства є досягнення максимального прибутку. Усі інші цілі підпорядковані цьому головному завданню, оскільки прибуток є основою та джерелом фінансових ресурсів для подальшого розвитку. Саме управління витратами є засобом досягнення підприємством високого економічного результату. Наведено основні підходи до поняття «управління витратами», визначено основні підходи щодо управління ними. Управління витратами підприємства являє собою процес цілеспрямованого впливу на склад, структуру та поведінку витрат, а також їх облік, планування, аналіз та контроль для прийняття управлінського рішення щодо їх оптимізації. Вибір найбільш придатної конфігурації елементів системи управління витратами при цьому сприяє створенню і забезпеченню оптимального економічного способу виробництва та реалізації продукції. Система управління витратами має функціональний та організаційний аспекти. Вона включає такі функціональні підсистеми: пошук та виявлення факторів економії ресурсів; нормування витрат ресурсів; планування витрат ресурсів за їх видами; облік та аналіз витрат ресурсів; стимулювання економії та ресурсів та зниження їх витрати.
Показано, що функціональний підхід до розподілу витрат за видами діяльності сприятиме вирішенню зазначених проблем. Він дозволить впровадити нову систему вимірювань та виявляти найбільш точні показники собівартості виробленої продукції, на основі вимірювання та розподілу витрат з урахуванням диференційованого споживання виробництвом ресурсів, що дозволить визначати сфери відповідальності менеджерів, а також оперативно вирішувати проблеми ціноутворення, скорочення витрат на основі аналізу витрат, сформованих за видами діяльності, здійснювати моделювання їхньої поведінки та на основі даних загальних витрат формувати фінансові кошториси та в цілому більш ефективно здійснювати управління витратами.
On the cosmological arrow of time
Authors: Henriksson Andreas 
Published: April 2023

The cosmological arrow of time is defined by the initial conditions of the Universe and its subsequent expansion. Wetterich [1] has proposed an alternative picture of the expanding Universe where the observed cosmological redshift can equivalently be viewed as originating from the increase in mass of particles over time. In this article, we address the following problem: How can the cosmological arrow of time be interpreted in a static Universe where the particle masses increase? We take the philosophical point of view that the set of minima in the effective potential of a symmetry-broken quantum field theory represents physically coexisting groundstates. Tunneling of energy, carried by instantons, within the set of groundstates, is suggested to induce the change in particle masses. The directionality in which the instanton energy tends to flow, i.e. from high-energy-density to low-energy-density groundstates, defines then the cosmological arrow of time. It is concluded that the premises on which this article is built, i.e. the assumption that the set of groundstates physically coexists, is invalid if it is found to be impossible to provide a sound argument for the increase in entropy within a contracting spacetime. This is because otherwise the second law of thermodynamics is violated.
English Needs Assessment Survey for International Students of Technology at the Budapest University of Technology and Economics in Hungary
Authors: Furka Ildikó 
Published: April 2023

Regular language instruction informed by needs assessment has been a widespread phenomenon in Teaching English as a Foreign language (EFL). In higher education (HE) institutions teaching English for Academic Purposes (EAP) based on research has also been a widely accepted trend. Nowadays the increasing number of international students in the Hungarian HE scenario has prompted faculties to support the development of students' language skills systematically. As one such institution, the Centre for Modern Languages (CML) at the Budapest University of Technology and Economics (BME) designed a questionnaire survey systematically to research the language needs of its international students of technology after having come across some anecdotal mismatches across faculties in the perception of the students' level of knowledge. International students of technology, their EFL teachers and their subject matter instructors were surveyed on how important they think certain language skills are for the students to succeed in the academic scenario. The results show that skills such as identifying main points in texts, summarising information in speech and in writing, or asking for clarification - all of pertain to the recognition or formation of structural elements in written and spoken texts - are seen as most important by the stakeholders. The results now inform the refreshment of course design and materials development at CML. Limitations are discussed together with future research recommendations, such as the need to thoroughly investigate non-linguistic issues influencing learning achievements, which may include cultural differences in learning strategies or learner-teacher expectations.
Pelatihan Kader Posyandu Sebagai Upaya Pencegahan Stunting Pada Balita Di Wilayah Kerja Kelurahan Jatimulya, Cilodong, Kota Depok, Jawa Barat
Authors: Indrawati Lili , Agustin Dinni 
Published: April 2023

Stunting adalah kondisi dimana balita memiliki panjang dan tinggi badan yang kurang jika dibandingkan dengan umur disebabkan oleh faktor multidimensi yaitu faktor gizi yang buruk yang dialami balita, kekurangan pengetahuan ibu tentang kesehatan dan gizi yang berdampak pada tingkat kecerdasan, kerentanan terhadap penyakit. Salah satu faktor yang berperan aktif dalam mendeteksi dini masalah stunting adalah peran seorang ibu balita dan kader. Angka prevalensi stunting di Depok pada 2021 terlihat sebesar 3,5 persen, yaitu sebanyak 3.675 dari 105.127 balita di Kota Depok. Data tersebut mengalami penurunan dari bulan Februari 2021 sebesar 4,7 persen sebanyak 4.923 dari total 102.815 balita di Depok. Walaupun secara angka terjadi penurunan, akan tetapi di kel. Jatimulya Kec. Cilodong, Depok, terdapat angka kasus stunting yang cukup tinggi yaitu sebesar 47 kasus di 9 RW. Dengan alasan tersebut maka dilaksanakan pelatihan kepada Kader dan Ibu dengan balita terkait stunting diwilayah kerja Kel. Jatimulya dengan tujuan untuk dapat mencegah kejadian stunting. Hasil pelatihan diharapkan dapat memberdayaan kader kesehatan dalam melaksanakan tugasnya dalam memberikan penyuluhan kepada masyarakat khususnya ibu hami, dan ibu dengan balita secara konsisten dan berkesinambungan sehingga dapat meningkatkan kinerja kader dalam pencegahan stunting dan pelayanan posyandu yang optimal.
Kata kunci: stunting, pelatihan, kader
Intratumoral microbiome impacts immune infiltrates in tumor microenvironment and predicts prognosis in esophageal squamous cell carcinoma patients
Authors: Zhang Shuyue , Zhang Shuishen , Ma Xiaofan , Zhan Jing , Pan Chuqing , Zhang Huizhong , Xie Xiuying , Wen Jing , Xie Xuan 
Published: April 2023

BackgroundDifferent intratumoral microbiotaexist in different tumors and play a crucial function in carcinogenesis. However, whether they impact clinical outcomes in esophageal squamous cell carcinoma (ESCC) and their mechanism remain unclear.Methods16S rDNA amplicon sequencing was performed on surgically resected samples from 98 ESCC patients to analyze intratumoral microbiome abundance and composition. Multiplex fluorescent immunohistochemistry staining was used to profile the phenotypes of immune infiltrates in the tumor microenvironment (TME).ResultsPatients with higher intratumoral Shannon index had significantly worse surgical outcomes. When patients were divided into short-term survivors and long-term survivors based on the median survival time, both intratumoral alpha-diversity and beta-diversity were found to be significantly inconsistent, and the relative abundance of Lactobacillus and Leptotrichia emerged as the two microorganisms that probably influenced the survival of ESCC patients. Only Lactobacillus in ESCC was validated to significantly worsen patients’ prognoses and to be positively correlated with the Shannon index. Multivariate analysis revealed that the intratumoral Shannon index, the relative abundance of Lactobacillus, and the pathologic tumor–node–metastasis (pTNM) stage were independently associated with patients’ overall survival. Furthermore, the relative abundance of both Lactobacillus and Shannon index was positively correlated with the proportions of PD-L1+ epithelial cells (ECs) and tumor-associated macrophages (TAMs). The Shannon index was negatively correlated with the proportions of natural killer (NK) cells in the TME.ConclusionsA high abundance of intratumoral Lactobacillus and bacterial alpha-diversity was associated with the formation of the immunosuppressive TME and predicted poor long-term survival in ESCC patients.
Integrated analysis of the lncRNA-miRNA-mRNA network based on competing endogenous RNA in atrial fibrillation
Authors: Wang Manman , An Guoying , Wang Benxuan , Chen Yuanyuan , Liu Genli , Wang Xin , Liu Shuai , Zhang Daozou , Sun Dandan , Zhang Yanyan , Shen Tong , Li Xiangting 
Published: April 2023

ObjectiveLong non-coding RNAs (lncRNAs) play pivotal roles in the transcriptional regulation of atrial fibrillation (AF) by acting as competing endogenous RNAs (ceRNAs). In the present study, the expression levels of lncRNAs of sinus rhythm (SR) patients and AF patients were investigated with transcriptomics technology, and the lncRNA-miRNA-mRNA network based on the ceRNA theory in AF was elaborated.MethodsLeft atrial appendage (LAA) tissues were obtained from patients with valvular heart disease during cardiac surgery, and they were divided into SR and AF groups. The expression characterizations of differentially expressed (DE) lncRNAs in the two groups were revealed by high-throughput sequencing methods. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed, and the lncRNA-miRNA-mRNA-mediated ceRNA network was constructed.ResultsA total of differentially expressed 82 lncRNAs, 18 miRNAs, and 495 mRNAs in human atrial appendage tissues were targeted. Compared to SR patients, the following changes were found in AF patients: 32 upregulated and 50 downregulated lncRNAs; 7 upregulated and 11 downregulated miRNAs; and 408 upregulated and 87 downregulated mRNAs. A lncRNA-miRNA-mRNA network was constructed, which included 44 lncRNAs, 18 miRNAs, and 347 mRNAs. qRT-PCR was performed to verify these findings. GO and KEGG analyses suggested that inflammatory response, chemokine signaling pathway, and other biological processes play important roles in the pathogenesis of AF. Network analysis based on the ceRNA theory identified that lncRNA XR_001750763.2 and Toll-like receptor 2 (TLR2) compete for binding to miR-302b-3p. In AF patients, lncRNA XR_001750763.2 and TLR2 were upregulated, and miR-302b-3p was downregulated.ConclusionWe identified a lncRNA XR_001750763.2/miR-302b-3p/TLR2 network based on the ceRNA theory in AF. The present study shed light on the physiological functions of lncRNAs and provided information for exploring potential treatments for AF.
Anti-apoptotic and anti-fibrotic efficacy of exercise training in hypertensive hearts: A systematic review
Authors: Akbar Adjar Yusrandi , Cui Zhen-Yang , Hsu Che-Jui , Li Yan-Zhang , Rahman Ferry Fadzlul , Xia Chunqiu , Yang Ai-Lun , Lee Shin-Da 
Published: April 2023

BackgroundThis review aims to summarize the antiapoptotic, pro-survival, and antifibrotic effects of exercise training in hypertensive hearts.MethodsKeyword searches were conducted in PubMed, Web of Science, and Scopus in May 2021. Research published in English on the effects of exercise training on the apoptosis, survival, and fibrosis pathways in hypertension was included. The CAMARADES checklist was used to determine the quality of the studies. Two reviewers independently implemented predesigned protocols for the search and selection of studies, the assessment of study quality, and the evaluation of the strength of evidence.ResultsEleven studies were included after selection. The duration of the exercise training ranged from 5 to 27 weeks. Nine studies showed that exercise training improved cardiac survival rates by increasing IGF-1, IGF-1 receptor, p-PI3K, Bcl-2, HSP 72, and p-Akt. Furthermore, 10 studies showed that exercise training reduced apoptotic pathways by downregulating Bid, t-Bid, Bad, Bak, Bax, TNF, and FADD. Finally, two studies reported the modification and subsequent improvement of physiological characteristics of fibrosis and decreased MAPK p38 and PTEN levels by exercise training in the left ventricle of the heart.ConclusionsThe findings of the review showed that exercise training could improve cardiac survival rates and attenuate cardiac apoptotic and fibrotic pathways in hypertension, suggesting that exercise training could act as a therapeutic approach to prevent hypertension-induced cardiac apoptosis and fibrosis.Systematic Review Registrationhttps://www.crd.york.ac.uk, identifier: CRD42021254118.
A novel risk stratification model for STEMI after primary PCI: global longitudinal strain and deep neural network assisted myocardial contrast echocardiography quantitative analysis
Authors: Li Mingqi , Zeng Dewen , Zhou Yanxiang , Chen Jinling , Cao Sheng , Song Hongning , Hu Bo , Yuan Wenyue , Chen Jing , Yang Yuanting , Wang Hao , Fei Hongwen , Shi Yiyu , Zhou Qing 
Published: April 2023

BackgroundIn ST-segment elevation myocardial infarction (STEMI) with the restoration of TIMI 3 flow by percutaneous coronary intervention (PCI), visually defined microvascular obstruction (MVO) was shown to be the predictor of poor prognosis, but not an ideal risk stratification method. We intend to introduce deep neural network (DNN) assisted myocardial contrast echocardiography (MCE) quantitative analysis and propose a better risk stratification model.Methods194 STEMI patients with successful primary PCI with at least 6 months follow-up were included. MCE was performed within 48 h after PCI. The major adverse cardiovascular events (MACE) were defined as cardiac death, congestive heart failure, reinfarction, stroke, and recurrent angina. The perfusion parameters were derived from a DNN-based myocardial segmentation framework. Three patterns of visual microvascular perfusion (MVP) qualitative analysis: normal, delay, and MVO. Clinical markers and imaging features, including global longitudinal strain (GLS) were analyzed. A calculator for risk was constructed and validated with bootstrap resampling.ResultsThe time-cost for processing 7,403 MCE frames is 773 s. The correlation coefficients of microvascular blood flow (MBF) were 0.99 to 0.97 for intra-observer and inter-observer variability. 38 patients met MACE in 6-month follow-up. We proposed A risk prediction model based on MBF [HR: 0.93 (0.91–0.95)] in culprit lesion areas and GLS [HR: 0.80 (0.73–0.88)]. At the best risk threshold of 40%, the AUC was 0.95 (sensitivity: 0.84, specificity: 0.94), better than visual MVP method (AUC: 0.70, Sensitivity: 0.89, Specificity: 0.40, IDI: −0.49). The Kaplan-Meier curves showed that the proposed risk prediction model allowed for better risk stratification.ConclusionThe MBF + GLS model allowed more accurate risk stratification of STEMI after PCI than visual qualitative analysis. The DNN-assisted MCE quantitative analysis is an objective, efficient and reproducible method to evaluate microvascular perfusion.
Highly reliable GIGA-sized synthetic human therapeutic antibody library construction
Authors: Huang Chao-Yang , Lok Ying-Yung , Lin Chia-Hui , Lai Szu-Liang , Wu Yen-Yu , Hu Chih-Yung , Liao Chu-Bin , Ho Chen-Hsuan , Chou Yu-Ping , Hsu Yi-Hsuan , Lo Yu-Hsun , Chern Edward 
Published: April 2023

BackgroundMonoclonal antibodies (mAbs) and their derivatives are the fastest expanding category of pharmaceuticals. Efficient screening and generation of appropriate therapeutic human antibodies are important and urgent issues in the field of medicine. The successfulin vitrobiopanning method for antibody screening largely depends on the highly diverse, reliable and humanized CDR library. To rapidly obtain potent human antibodies, we designed and constructed a highly diverse synthetic human single-chain variable fragment (scFv) antibody library greater than a giga in size by phage display. Herein, the novel TIM-3-neutralizing antibodies with immunomodulatory functions derived from this library serve as an example to demonstrate the library’s potential for biomedical applications.MethodsThe library was designed with high stability scaffolds and six complementarity determining regions (CDRs) tailored to mimic human composition. The engineered antibody sequences were optimized for codon usage and subjected to synthesis. The six CDRs with variable length CDR-H3s were individually subjected to β-lactamase selection and then recombined for library construction. Five therapeutic target antigens were used for human antibody generationviaphage library biopanning. TIM-3 antibody activity was verified by immunoactivity assays.ResultsWe have designed and constructed a highly diverse synthetic human scFv library named DSyn-1 (DCB Synthetic-1) containing 2.5 × 1010phage clones. Three selected TIM-3-recognizing antibodies DCBT3-4, DCBT3-19, and DCBT3-22 showed significant inhibition activity by TIM-3 reporter assays at nanomolar ranges and binding affinities in sub-nanomolar ranges. Furthermore, clone DCBT3-22 was exceptionally superior with good physicochemical property and a purity of more than 98% without aggregation.ConclusionThe promising results illustrate not only the potential of the DSyn-1 library for biomedical research applications, but also the therapeutic potential of the three novel fully human TIM-3-neutralizing antibodies.