bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ganoderma lucidum Polysaccharide Peptide Reduces Oxidative Stress and Improves Renal Function in Patient with Cardiometabolic Syndrome
Authors: Wardhani Syanindita Puspa , Nadliroh Khilmi Ainun , Aishaqeena Al Mazida Fauzil , Sonia Fahriza Abid , Suryo Adji Achmad Guntur Hermawan , Hanim Intan Masyfufah , Hidayatulloh Rizkia Milladina , Rahimah Anna Fuji , Rizal Ardian , Sugita Peter , Sandra Ferry , Sargowo Djanggan 
Published: April 2023

BACKGROUND: Cardiometabolic syndrome is a risk factor for the development of diseases related to cardiovascular disease and decreased renal function. Ganoderma lucidum polysaccharide peptide (GLPP) has been reported to have anti-inflammatory and antioxidant properties. The current study was conducted to investigate the role of GLPP in inflammatory, oxidative stress and renal function markers of cardiometabolic subjects.METHODS: A randomized double-blinded perspective control trial with pre-post design was conducted. Cardiometabolic syndrome subjects were treated with placebo or GLPP for 60 days. Blood serum was collected from each subject before the first capsule consumption and one day after the last capsule consumption. Serum tumor necrosis factor (TNF)-α, high-sensitivity-C-Reactive Protein (hs-CRP) and malondialdehyde (MDA) levels were measured using enzyme-linked immunosorbent assay, while superoxide dismutase (SOD) level was measured using colorimetric assay. Serum urea and creatinine levels were measured using a clinical analyzer. The Cockroft-Gault formula was used to calculate estimated glomerular filtration rate (eGFR).RESULTS: Compared with the control group, the MDA level was significantly reduced, while the SOD level was significantly increased in the GLPP treatment group. Furthermore, serum urea and creatinine were lowered, while eGFR was increased in the GLPP treatment group.CONCLUSION: Treatment of GLPP for 60 days could be beneficial for lowering oxidative stress and improving renal function of patients with cardiometabolic syndrome.KEYWORDS: Ganoderma lucidum, cardiometabolic syndrome, inflammation, oxidative stress, renal function
SARS-CoV-2 Neutralization Assay System using Pseudo-lentivirus
Authors: Armimi Anastasia , Syuaib Afina Firdaus , Vanya Katherine , Tan Marselina Irasonia , Natalia Dessy , Chen David Virya , Ono Chikako , Matsuura Yoshiharu , Artarini Anita , Giri-Rachman Ernawati Arifin 
Published: April 2023

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects humans' lower respiratory tracts and causes coronavirus disease-2019 (COVID-19). Neutralizing antibodies is one of the adaptive immune system responses that can reduce SARS-CoV-2 infection. This study aimed to develop a SARS-CoV-2 neutralization assay system using pseudo-lentivirus.METHODS: The plasmid used for pseudo-lentivirus production was characterized using restriction analysis. The gene encoding for SARS-CoV-2 spike protein was confirmed using sequencing. The transfection pseudo-lentivirus optimal condition was determined by choosing the transfection reagents and adding centrifugation step. Optimal pseudo-lentivirus infection was analysed using fluorescent assay and luciferase assay. The optimal condition of pseudo-lentivirus infection was determined by the target cell type and the number of pseudo-lentiviruses used for neutralization test. SARS-CoV-2 pseudo-lentivirus was used to detect neutralizing antibodies from serum samples.RESULTS: The plasmid used for pseudo-lentivirus production was characterized and confirmed to have no mutations. Lipofectamine 2000 reagent generated pseudo-lentivirus with a higher ability to infect target cells, as indicated by a percentage green fluorescent protein (GFP) of 12.68%. Pseudo-lentivirus centrifuged obtained more stable results in luciferase expression. Optimal pseudo-lentivirus infection conditions were obtained using puromycin-selected HEK 293T-ACE2 cells as target cells. The number of pseudo-lentiviruses used in the neutralization assay system was multiplicity of infection (MOI) 0.075. Serum A samples with a 1:10 dilution had the highest neutralizing antibody activity.CONCLUSION: This study shows that SARS-CoV-2 neutralization assay system using pseudo-lentivirus successfully detected neutralizing antibodies in human serum, which were indicated by a decrease in the percentage of pseudo-lentivirus infections.KEYWORDS: COVID-19, neutralizing antibody, neutralization assay, pseudo-lentivirus, SARS-COV-2
Analysis of cavern and narrows of drilling wells in Azerbaijan fields
Authors:   Azerbaijan State Oil and Industry University, Ibrahimov Rafiq S. , Bahshaliyeva Shirin O. ,   Azerbaijan State Oil and Industry University, Efendiyeva Leyla ,   Azerbaijan State Oil and Industry University, Ibrahimov Zaur R. ,   Bаker Hughes, Azerbaijan
Published: April 2023

An analysis of numerous well data from the Karabagly and Kursangi monocline regions in Azerbaijan showed that the main reasons of natural curvature are structural and geological conditions of wells. In contrast to a number of fields where wells are naturally bent in only one direction under the combination of geological, technical and technological factors, there are three other directions in the areas of the Karabagly and Kursangi monocline. It is suggested that according to the proposed technology, drilling intervals are minimized by an assembly with a crooked sub, and the technical and economic parameters of drilling are improved. With an increase in the content of alkaline reagents in the drilling fluid, despite a significant decrease in the absolute value of fluid loss, the likelihood of complications increases. One of the main requirements for maintaining the integrity and stability of the wellbore is the prevention of filtration. This condition imposes a certain limitation on the amount of fluid loss in drilling fluids. In drilling practice, it is necessary to strive not only to minimize the fluid loss of flushing fluids, but also to the qualitative and quantitative evaluate various additives that slow down their physical and chemical impact on the rocks forming the walls of the well.
СОСТОЯНИЕ СТРУКТУРЫ ПОТРЕБЛЕНИЯ ПРОДУКТОВ ПИТАНИЯ НАСЕЛЕНИЕМ СВЕРДЛОВСКОЙ ОБЛАСТИ
Authors: Таскин Фёдор Александрович 
Published: April 2023

Актуальность исследования связана с тем, что неправильное и несбалансированное питание увеличивает риск возникновения многих социально значимых заболеваний человека, влияет на социально-экономическое развитие региона. Цель статьи − анализ структуры потребления продуктов питания населением Свердловской области. Методы: сопоставительный анализ, статистический анализ и специальные методы визуализации данных. Результаты: рассмотрена структура потребления продуктов питания в домашних хозяйствах в Уральском федеральном округе за 2021 г.; сопоставлено потребление продуктов питания населением Свердловской области с другими регионами Уральского федерального округа; проанализировано потребление основных групп продуктов питания населением в Российской Федерации и Свердловской области, а также проведено сравнение фактического потребления с рекомендуемыми нормами за 2018–2021 гг.; оценен уровень потребления продуктов питания населением региона в городской и сельской местностях; описано влияние отдельных групп продуктов питания на здоровье человека; рассчитан уровень самообеспечения Свердловской области основными видами сельскохозяйственной продукции. Сформулирован вывод о несоответствии потребления продуктов питания населением Свердловской области рекомендуемым нормам, о существовании общих проблем в потреблении продуктов питания домашними хозяйствами в городской и сельской местностях, при этом выявлен факт наличия более рационального питания у городского населения по сравнению с сельским. Отмечено, что Свердловская область не может полностью обеспечить потребность региона в ряде основных продуктов животноводства и растениеводства. Сформулированы рекомендации по достижению рациональной структуры питания населения Свердловской области.
DETERMINANT OF CONSUMER DECISION ON ISLAMIC BANKING
Authors: Sari Dian Novita , Siswanto Siswanto , Maksum Ikhsan , Abdani Fadlil , Khan Ryan Basith Fasih , Retnasih Nora Ria , Setiani Setiani , Masyhuri Masyhuri 
Published: April 2023

This study investigates the determinant of customer decisions in Islamic banks' savings: motivation, promotion, and religiosity. Trust variable as a form of research novelty as a mediation. This study uses a quantitative approach with explanatory research. Using purposive sampling, the sample is 95 Islamic bank customers in Nganjuk City, East Java. Data are analyzed using structural equation modeling with Smartpls software. This research generally describes the factors that can improve customer decisions in opening savings at Islamic banks, such as motivation, promotion, and religiosity. These three factors in this study proved that only direct motivation could improve customer decisions. The result means that the other two factors need a mediating variable in the form of customer trust in Islamic banks regarding the safety of money stored and guarantees free from usury. These findings can be a suggestion for the management of Islamic banks to do promotions more often, meaning that what has been done now is still inferior to conventional banks in promotion.
Rancang Bangun Mesin Pencucian Garam Dua Tingkat Skala Kecil
Authors: Siregar Tika Hafzara 
Published: April 2023

Kondisi perekonomian petani garam dan kualitas garam rakyat kerap kali membuat petani garam berada di posisi tawar yang lemah, sehingga harga jual garam di tingkat petani rendah. Mesin pengolahan garam konsumsi skala kecil perlu dirancang untuk meningkatkan nilai dari garam sehingga kesejahteraan petani garam dapat meningkat. Penelitian ini bertujuan untuk merancang mesin pencucian garam krosok yang bertujuan untuk meningkatkan kandungan NaCl dan menghilangkan zat-zat pengotor lain seperti CaSO4, MgSO4, MgCl2 dan lain-lain. Mesin dirancang menggunakan sistem pemutaran dengan mempertahankan nilai baume dari air tua pencuci garam pada nilai 25-28. Mesin dilengkapi dengan sensor baume untuk mengontrol nilai baume air tua. Variable lama waktu pencucian divariasikan untuk menghasilkan kualitas garam terbaik. Penelitian ini sudah merancang mesin pencucian garam dua tingkat dengan sistem pengontolan nilai 0Be yang dapat mencuci garam dengan air tua berkapasitas 50kg. Mesin ini melakukan 2 kali proses pencucian garam. Alat ini berpenggerak motor listrik 1,5 HP untuk mengaduk garam krosok bersama air tua sehingga dapat melarutkan bahan-bahan pengotor dan mempertahankan NaCl dalam bentuk kristal. Kemurnian NaCl garam krosok meningkat sebesar 7,5% setelah mengalami pencucian selama 20 menit.
Aktivitas Antikanker Nanokapsul Ekstrak Mengkudu (Morinda citrifolia L.) dengan Pengujian in Vivo pada Fibrosarkoma Mencit Jantan Balb/c
Authors: Aisyah Nur , Ningtias Lulus Kartika , Marchianti Ancah Caesarina Novi , Piluharto Bambang , Cahyaningrum Deltaningtyas Tri , Retnowati Naning , Diniyah Nurud , Iswahyono Iswahyono , Fauziah Riska Rian 
Published: April 2023

Noni (Morinda citrifolia L.) is one of the many herbs which known as an anticancer agent. Nanoencapsulated form of noni extracts could help the body absorption and able to inhibit the proliferation of cancer cells in vitro. This study was conducted to examine the anticancer activity of nanoencapsulated noni extracts in vivo as the anti-proliferation agent of cancer cells. Noni extract was obtained by maceration method using water as a solvent. The nanocapsule of noni extracts was made using the ionic gelation method by magnetic stirrer with the speed of 1500 rpm. In vivo anticancer activity test was conducted in Balb/c male mice by comparing the treatment of nanoencapsulation noni extracts and non-encapsulated extracts. The result showed that the nanoencapsulated noni extracts have a particle size of 27-59 nm. Percent of inhibition of nanocapsule on cancer cells (specifically on fibrosarcoma of Balb/c male mice) were equal to 54.75% (P2), while non-encapsulated is 49.72% (P1). Nanocapsule of noni extracts has anticancer activity better than non-encapsulated form on fibrosarcoma of Balb/c male mice.
Keywords: anticancer, nanoencapsulation, noni extract
Desain Kemasan Minuman Sari Buah Mengkudu (Morinda citrifolia) untuk Meningkatkan Pemasaran di UD Manjur Makmur
Authors: Wulandari Anita , Cahyani Wahyu Kanti Dwi , Widodo Richardus , Widyalasmono R. Paulus 
Published: April 2023

One of the variant of Morinda citrifolia fruit drink is called noni juice and known as Noni Super Power’s brand name at UD Manjur Makmur. This beverage is naturally fermented by spontaneous fermentation at 28-30°C during six months in a bottle that has been cleaned and tightly closed. During the marketing process to consumers, the design packaging of noni drink is needed to attract consumers buying. Meanwhile, the primary packaging of noni juice at UD Manjur Makmur is less attractive to consumers, there is also no secondary and tertiary packaging and it became the product's packaging weakness. So, label and packaging for noni juice products are needed to design to promote product identity and display product visuals to raise the consumers’ interest. This study was conducted to solve these problems. In this research, benchmarking of products, the Guide on Labeling of Processed Food Agency for National Drug and Food Control (2020), and the observation, imitation, modify methodology were applied. This research resulted in the design of primary, secondary, and tertiary packaging for noni fruit juice drinks. Following the benchmarking, the guide of processed food label requirements, and evaluating the packaging and labels (2020), the new design packaging and labels were better than before. As packaging of noni juice, plastic bottles with new design label are used for primary packaging, followed by rectangles (boxes) made from samson paper (size of 6,3 × 6,3 × 18 cm) for secondary packaging, and cardboard boxes made from corrugate (size of 30 × 20 × 40 cm) for tertiary packaging. Furthermore, the new design packaging (especially tertiary packaging) can accommodate a large amount of noni juice bottles during the marketing and distribution of its product.
Keywords: consumers’ interest, noni juice, label, packaging
Profile of Skin Tumors at Dr. Zainoel Abidin General Hospital Dermatology and Venerology Outpatient Clinic in 2017 – 2021 : A Retrospective Study
Authors: Wahyu Lestari  , Nanda Earlia Fitria  , Sitti Hajar  , Mimi Maulida  
Published: April 2023

Background: Skin tumors are swellings caused by proliferation or failure of cell death mechanisms. Based on the type of growth, skin tumors are divided into benign tumors and malignant tumors. Purpose: To investigate the incidence of skin tumors in Dr. Zainoel Abidin General Hospital outpatient clinic. Methods: This study is a descriptive study with total sampling. The diagnosis of skin tumors is assessed based on medical records filled by Dr. Zainoel Abidin General Hospital Dermatovenerologist in January 2017-September 2021. Result: The results showed patients diagnosed with benign skin tumors had as many as 360 subjects and malignant tumors had as many as 4 samples. The majority of women are affected by benign and malignant skin tumors. Based on the age of benign tumors dominated by the age of 22-45 years while in malignant tumors dominated by 45-64 years. The majority of the sample comes from Banda Aceh, based on where the most of them reside. Based on the size of lesions, benign tumors are dominated by lesions that are less than 0.5 cm in size, while malignant tumors are dominated by lesions that are larger than 0.5 cm in size. Based on the presence and absence of recursion the entire dominant sample has no recursion. Based on the physical treatment in benign tumors are dominated by electrocautery action while malignant tumors are the same number between general surgery and FNAB. Conclusion: most of the skin tumors found in Dr. Zainoel Abidin General Hospital dermatology and venerology outpatient clinic are benign
The Role of Employer Branding in Work-life Balance and Employee Retention Relationship among Generation Z Workers: Mediation or Moderation?
Authors: Hendriana Evelyn , Christoper Albert , Zain Handika Oemardi Adhitama , Pricilia Natasha 
Published: April 2023

Objective: This study aims to investigate two models that examine the role of employer branding in the relationship between work-life balance and employee retention in Generation Z workers.
Design/Methods/Approach: This study applied quantitative methods by distributing questionnaires using google forms. A purposive sample of 189 Generation Z workers in Greater Jakarta, Indonesia, was used to test the models. The data was processed using SmartPLS 3 Software.
Findings: The results of the PLS-SEM analysis revealed a significant relationship between work-life balance, job stress, emotional exhaustion, and employee retention. Instead of mediating the relationship between work-life balance and employee retention, this study revealed that employer branding significantly moderated the relationship between emotional exhaustion and employee retention among Generation Z workers. These findings could be used to develop a human capital strategy to retain Generation Z employees.
Originality/Value: Among many studies on the relationship between work-life balance and employee retention, only a few focus on Generation Z workers. This generation also places greater emphasis on employer branding when considering their workplace. However, employer branding is rarely integrated into work-life balance research. This study extends the application of social exchange theory to explain the relationship between work-life balance (WLB) and employee retention by integrating employer branding into the model.
Practical/Policy implication: Given the results, organizations may provide flexibility that enables employees to work from anywhere and anytime. Moreover, companies must design strategies to manage WLB, such as flexible working hours to allow employees to manage their work schedules according to their needs and reduce workplace conflicts. Companies are advised not to assign responsibilities that do not correspond to the employee’s position or job description. Organizations may provide mindfulness training through meditation during breaks or before and after work hours to help them relax from their workload and avoid emotional exhaustion. Lastly, companies must engage in internal marketing activities by creating positive work culture, designing clear career paths, providing training, offering attractive benefits, and providing opportunities for employees to grow and develop.
The Effect of Self-Control on Loan Repayment Decisions of Women Market Vendors in Mbeya Municipality, Tanzania
Authors: Gomera William Clifford , Ngollo Magwana  Ibrahim 
Published: April 2023

Objective: This study aims to examine the effect of self-control on loan repayment decisions of women market vendors in Mbeya municipality, Tanzania.
Design/Methods/Approach: This study employed a mixed research design. Primary data was collected via questionnaires and semi-structured interviews. A stratified random sampling technique was used to come up with a sample of 348 respondents selected from a population of 1741 women market vendors. Finally, descriptive statistics and regression analysis were utilized to process the collected data.
Findings: The result of data analysis determined that self-control had a significant adverse effect on loan repayment decision
Originality/Value: This study is unique since it studies self-control and loan repayment amongst women market vendors. The specificity of the set population allowed for a more in-depth and nuanced understanding of the experiences and challenges faced by this specific group of individuals hence deriving originality in this research.
Practical/Policy implication: Findings are useful to policymakers and microcredit providers. Policymakers should promote activities and education that assist Tanzanians in attaining self-control. They should devise policies to make loans more affordable and easier to repay. Microcredit lenders should utilize subjective measures of self-control on loan applications as it is highly effective in enhancing repayment when coupled with high levels of financial literacy.
The Role of Knowledge and Penetration of Fintech Services in Improving MSMEs of Fishermen and Marine Farmers in Remote Small Islands Region
Authors: Pentury Frischilla 
Published: April 2023

Objective: This study aims to investigate the impact of knowledge and current penetration of fintech services on the overall performance of micro, small, and medium-sized enterprises (MSMEs), which in this case were fishermen and marine farmers.
Design/Methods/Approach: This study utilized data from nine fishing villages with two hundred respondents. The data was collected using a questionnaire based on the purposive sampling technique, then analyzed using SmartPLS and path analysis.
Findings: Knowledge had direct and indirect positive and significant effects on the overall managerial performance of fishermen and marine farmers. In addition, the user experience might increase the rapid adoption of fintech, improving the performance of MSMEs in small island regions.
Originality/Value: This study highlights the importance of fintech knowledge for increasing the uptake and impact of fintech among MSMEs in remote small island areas, which has escaped the attention of scientific research.
Practical/Policy implication: Given the results, more effort is needed to increase the knowledge of MSMEs in small islands region regarding services and risk to increase the participation of MSMEs in fintech.
Is Patellar Instability a Contraindication to Semiextended Tibial Nailing?
Authors: Ray Gabrielle S. , Leroy Taryn E. , Ryan Scott P. , Bragg Jack T. , Salzler Matthew J. 
Published: April 2023

Case:
We report a 40-year-old woman with undiagnosed patellofemoral instability that worsened 8 months after intramedullary nailing of a distal left tibia fracture in the semiextended position through a partial medial parapatellar approach. Patella stability and asymptomatic knee function were restored after IM nail removal, medial patellofemoral ligament repair, and left tibial tubercle transposition.

Conclusion:
The optimal surgical approach for tibial IM nailing in patients with chronic patellar instability has not been described. Clinicians should be cognizant of the potential for worsening patellofemoral instability in these patients when using the medial parapatellar approach in the semiextended position.
Nonunion of Diaphyseal Humerus Fracture in an Infant
Authors: Beraún-Coronel Luis , Cardenas-Escalante Jhanella , Sinti-Paredes Diego A. , Chamorro-Robles Fredy , Porres-Varona William 
Published: April 2023

Case:
A 9-month-old infant girl with Down syndrome presented with an atrophic nonunion of the right humerus diaphysis secondary to birth trauma. Surgical intervention included open reduction and external fixation plus cadaveric cancellous bone allograft and platelet-rich plasma and then was changed to an external fixator in axial compression. At 16 months after surgery, bone healing was achieved.

Conclusion:
Nonunions in infants are rare, and their treatment is a challenge; an adequate vascular supply with good stabilization and reduction are keys to management. We believe that the improvement in reduction and stability under axial compression were the keys to achieve consolidation.