bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Cardiac Remodeling and/or Myocardial Fibrosis Based on Hemodynamic Parameters of Vena Cava in Athletes
Authors: Liu Bin-yao , Zhang Fan , Tang Min-song , Kou Xing-yuan , Liu Qian , Fan Xin-rong , Li Rui , Chen Jing 
Published: January 2025

Purpose:
This study aimed to assess the hemodynamic changes in the vena cava and predict the likelihood of Cardiac Remodeling (CR) and Myocardial
Fibrosis (MF) in athletes utilizing four-dimensional (4D) parameters.

Materials and Methods:
A total of 108 athletes and 29 healthy sedentary controls were prospectively recruited and underwent Cardiac Magnetic Resonance (CMR)
scanning. The 4D flow parameters, including both general and advanced parameters of four planes for the Superior Vena Cava (SVC) and Inferior
Vena Cava (IVC) (sheets 1-4), were measured and compared between the different groups. Four machine learning models were employed to
predict the occurrence of CR and/or MF.

Results:
Most general 4D flow parameters related to VC were increased in athletes and positive athletes compared to controls (p < 0.05). Gradient Boosting
Machine (GBM) was the most effective model in sheet 2 of SVC, with the area under the curve values of 0.891, accuracy of 85.2%, sensitivity of
84.6%, and specificity of 85.4%. The top five predictors in descending order were as follows: net positive volume, forward volume, waist
circumference, body weight, and body surface area.

Conclusion:
Physical activity can induce a high flow state in the vena cava. CR and/or MF may elevate the peak velocity and maximum pressure gradient of the
IVC. This study successfully constructed a GBM model with high efficacy for predicting CR and/or MF. This model may provide guidance on the
frequency of follow-up and the development of appropriate exercise plans for athletes.
High Resolution Medical Image Inpainting Based on Super Resolution
Authors: Sheng Fangqing , Jin Lijiao , Ni Yueli , Wang Qianna 
Published: January 2025

Introduction:
Image inpainting techniques and patents have made great progress in recent
years. However, with higher image resolution, the large amount of computation and memory
requirements cause great difficulties for training.

Method:
We propose a medical image inpainting model that utilizes super-resolution techniques
to enhance the resolution of images during the repair process. Moreover, to maximize the utilization
of semantic information and enhance network performance, we incorporate multi-scale dense
residual blocks for feature extraction from the image.

Results:
Meanwhile, we utilize structural similarity as a loss function to encourage the network to
synthesize more meaningful structural textures. Experimental results demonstrate that HRMII can
effectively reduce the computation and memory occupation of the high-resolution image inpainting
model, and obtain satisfactory inpainting results.

Conclusion:
Additionally, ablation studies have substantiated the efficacy of diverse modules
within the network.
Pseudo-epitheliomatous Hyperplasia and Skin Infections
Authors: Delahaye Thibaut , Orduz-Robledo Marianna , Beltran A Motta , Robledo Mary-Ann , Sigha Berline Odette , Collins Patrick , Mokni Mourad , Del Giudice Pascal , Tassoudji Nazli , Nikkels Arjen F. 
Published: January 2025

Introduction
The histological pattern of pseudo-epitheliomatous hyperplasia (PEH) may be encountered in a large series of verruciform/crateriform skin lesions (VC) with or without central ulceration/crusting. Beside neoplastic and inflammatory processes, this clinico-histological pattern may be associated with an extensive range of infectious agents.

Materials and Methods
A literature search was performed to identify viral, bacterial, fungal, and parasitic mucocutaneous infections potentially presenting with a clinical/histological VC-PEH pattern.

Results
A VC-PEH pattern was reported in parasitic (n=5), viral (n=6), bacterial (n=10), and fungal (n=12) mucocutaneous infections. The infection-linked VC-PEH pattern was typically linked to longstanding mucocutaneous processes. The human papillomavirus (HPV) family, Epstein-Barr virus, poxvirus, and polyomavirus-linked VC-PEH patterns seem to act as direct triggers of keratinocytic hyperproliferation whereas the VC-PEH patterns observed during other viral, parasitic, bacterial and fungal infections probably represent a reactive pattern of the epidermis to chronic mucocutaneous infections. The VC-PEH pattern was also more frequently reported in immunocompromised compared to immunocompetent patients. The risk of the development of a cutaneous squamous cell carcinoma in chronic VC-PEH should not be overlooked.

Conclusion
In the event of longstanding, slowly progressing, isolated, or more profuse VC-PEH skin lesions, a thorough search for infectious agents should be considered, particularly in the immunocompromised patient.
Special Economic Measures as a Form of Restriction of Freedom of Economic Activity in the Russian Federation
Authors: Degtyarev M. A. 
Published: January 2025

The article considers the institute of special economic measures as a specific form of restriction of freedom of economic activity in Russia.The article characterizes the essence of special economic measures, defines their individual varieties that have the greatest impact on the realization of the constitutional principle of freedom of economic activity under sanctions. The author analyzes the normative-legal regulation of special economic measures, as well as the peculiarities of the functioning of certain types of special economic measures introduced and applied in the conditions of foreign economic restrictions.In the conditions of sanctions legal regime, which is extraordinary, restrictions on the freedom of economic activity of certain categories of economic entities can be significantly expanded, and the limits of state intervention in the implementation of this constitutional principle are narrowed.It seems reasonable in accordance with a number of principles of the institution of special economic measures. The measures include general principles of restriction of rights: the principle of compliance of the restriction with constitutional purposes (ensuring the defense and security of the state, protection of life and health of citizens, etc.), the principle of reasonableness of the restriction (application of the restriction in order to organize the functioning of the economic system of the Russian Federation), the principles of legality, urgency, proportionality of the restrictions imposed on existing threats.At the same time, the author admits the necessity to improve the Russian legislation on special economic measures (including in terms of specifying the grounds, mechanisms and guarantees of their application to economic entities).
Prospective validation study of a combined urine and plasma test for predicting high-grade prostate cancer in biopsy naïve men
Authors: Brøchner Pedersen Torben , Hvid Poulsen Mads , Lund Martin , Feddersen Søren , Albitar Maher , Aaberg Poulsen Charlotte , Lund Lars 
Published: January 2025

Objective: Early and accurate diagnosis of prostate cancer (PC) is crucial for effective treatment. Diagnosing clinically insignificant cancers can lead to overdiagnosis and overtreatment, highlighting the importance of accurately selecting patients for further evaluation based on improved risk prediction tools. Novel biomarkers offer promise for enhancing this diagnostic process. In this study, we aimed to externally validate a previously developed urine and plasma biomarker test in a biopsy-naïve population.
Materials and methods: Urine and blood samples were prospectively collected from 362 biopsy-naïve men with suspected PC before they underwent transrectal prostate biopsies. The expression levels of a 10-gene mRNA panel were quantified using reverse transcription/quantitative polymerase chain reaction of both urine and plasma. These gene expression levels, combined with clinical features and plasma prostate-specific antigen (PSA) levels, were used to predict the presence of International Society of Urological Pathology grade group ≥ 2 PC.
Results: Complete data were available for 314 patients. The sensitivity and specificity of the biomarker test were 87% (95% CI: 79–93%) and 42% (95% CI: 36–49%), respectively. The area under the curve was 0.76 (95% CI: 0.7–0.82) for the biomarker test probability and 0.65 (95% CI: 0.59–0.72) for PSA (p = 0.02). The test’s negative predictive value was 89% (CI: 81–94%).
Conclusion: This study did not replicate the previously reported high accuracy of the biomarker test, highlighting the need for further refinement and robust external validation to ensure reliable performance across diverse patient populations.
Fra heroin til fentanyl?
Authors: Waal Helge 
Published: January 2025

I dette kapittelet beskriver forfatteren utviklingen av narkotikabruken i Norge siden slutten av 1960-tallet, og trekker samtidig på egne erfaringer i ulike roller – som kliniker, forsker og sentral aktør i utviklingen av legemiddelassistert rehabilitering (LAR). Det legges spesiell vekt på bruken av opioider gjennom sekstiårsperioden, og han ender opp med en diskusjon om den økende bruken av nye opioider, som oksykodon og fentanyl.
Norsk narkotikapolitikk har sitt utspring i internasjonale regelverk fra 1920-tallet. Misbruket var på denne tiden i hovedsak iatrogent, det vil si at det utviklet seg som følge av medisinsk behandling. Avhengighet ble sett på som et medisinsk ansvar. Dette endret seg i løpet av 1960-tallet, da en fikk økende bruk av særlig cannabis i en ny generasjon av opposisjonelle ungdommer. Dette ble i første omgang møtt med sosialpolitikk og helsebaserte forebyggende tiltak. Men etter hvert ble strafferettspolitikken viktigere. På 1980-tallet kom det en økning i antall overdosedødsfall, samt AIDS og hepatitt blant heroinbrukere. Skadereduserende tiltak ble innført, og LAR-systemet ble utviklet fra 1998. Samtidig fikk talsmenn for reform av narkotikapolitikken mer oppmerksomhet. I løpet av de siste par tiårene har det utviklet seg en skremmende epidemi av opioidbruk og dødsfall i USA, hvor kommersielle aktører som Purdue Pharma hadde en vesentlig rolle. Også i Norge ser vi økende bruk av opioider i nye grupper, noe som fortjener oppmerksomhet.
Forfatteren diskuterer kritisk påstanden om at norsk narkotikapolitikk fortsatt kan karakteriseres som dominert av strafferetten. Han argumenterer for at bedre levekår for utsatte grupper i dagens situasjon kan være viktigere enn nye lovreformer.
Development of blended learning media on similarity and congruence topics
Authors: Ismet Ismet , Yerizon Yerizon , Fauzan Ahmad , Asmar Ali 
Published: January 2025

Background: The integration of technology in education has become increasingly important in enhancing student engagement. Mathematics, as a foundational subject, often requires innovative approaches to improve students' problem-solving skills and conceptual understanding. Blended learning combines traditional and digital methods, offering a flexible and effective solution for teaching complex mathematical topics.Aim: This research aims to develop valid, practical, and effective learning media for teaching the topics of similarity and congruence, enabling students to better understand these mathematical concepts. The media is designed based on the Blended Learning approach.Method: The development process follows the Plomp model, which consists of three stages: (1) the initial investigation stage to identify needs and context, (2) the product development stage where the media is designed and refined, and (3) the assessment stage to evaluate its validity, practicality, and effectiveness.Results: The developed learning media was validated with a validity score of 86.99, categorized as very valid. It also achieved a practicality score of 87.01, indicating it is very practical, and an effectiveness score of 83.33, categorized as effective.Conclusion: Blended Learning-based media for teaching similarity and congruence is a valid, practical, and effective tool that can enhance students' understanding of the topics.
Pengaruh Rasa Memiliki, Komunikasi, dan Kerjasama Tim terhadap Kinerja Anggota Unit Kegiatan Mahasiswa PSRM Simo Budi Utomo
Authors: Zulfian Zola , Widhianingrum Wahna , Widhianingrum Wahna , Setyawan Fery , Setyawan Fery 
Published: January 2025

Ketika anggota merasa mereka adalah bagian dari organisasi, mereka lebih termotivasi untuk berkontribusi secara maksimal, komunikasi yang baik sangat penting untuk memastikan informasi tersampaikan dengan jelas dan tepat waktu. Anggota yang bekerja dalam tim seringkali merasa lebih termotivasi dan didukung oleh rekan-rekan mereka, yang membantu meningkatkan kinerja individu dan tim secara keseluruhan. Hal ini memungkinkan anggota memahami tugas mereka dan bagaimana mereka harus melaksanakannya. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kuantitatif. populasi penelitian ini adalah seluruh Pengurus dan Anggota di UKM PSRM Simo Budi Utomo pada periode 2020-2023 yang berjumlah 40 orang yang juga digunakan sebagai sampel, Variabel bebas (independen) (X1) Rasa Memiliki, (X2) Komunikasi, dan (X3) Kerjasama Tim terhadap Variabel dependen (terikat) (Y) Kinerja Anggota dengan metode analisis data Uji Instrumen. menunjukkan bahwa nilai F hitung 23,482 F tabel 2,86 dan Sig. sebesar 0,000. Hasil tersebut berarti ketiga variabel bebas meliputi Rasa Memiliki (X1), Komunikasi (X2), Kerjasama Tim (X3) secara simultan berpengaruh terhadap variabel terikat.
KEANEKARAGAMAN EPIFAUNA DI HUTAN MANGROVE TELUK GILIMANUK, BALI
Authors: Jannah Andita Nur , Ernawati Ni Made , Wiweka Krisna Dewi Ayu Putu 
Published: January 2025

The intertidal zone is a unique coastal region, between the highest and lowest tide lines, experiencing submergence during high tide and exposure as land during low tide. This condition creates a dynamic habitat with high biodiversity. This study evaluates the diversity and abundance of Gastropods in the intertidal zone of Gilimanuk Bay, which faces pressure from human activities such as fisheries, energy, and tourism. The research was conducted in September-November 2023. Epifaunal sampling was carried out using the 2m x 2m quadrat transect method at 16 stations. At each station, 5 quadrat transects were sampled. The results showed that 29 species from 14 epifaunal families were found in Gilimanuk Bay, with the Shannon-Wiener diversity index indicating a moderate category (2.26-0.79). The evenness index varied between stations, while the dominance index indicated no dominant species. This study emphasizes the importance of conservation and management of natural resources to maintain the diversity and stability of the Gilimanuk Bay ecosystem.

Keywords: Ecosystem; Epifauna; Diversity; Gilimanuk Bay
Application of Foliar Fertilizer and Different Substrates on the Growth of Mouriri Guianensis aubl. Seedlings for use in the Ecological Restoration of the Mato Grosso Pantanal
Authors: Silva Elisangela Francisca Da , Nunes Josué Ribeiro Da Silva , Fernandez José Ricardo Castrillon , Morais Fernando Ferreira De , Nacanishi Ellen Cristina Magalhães , Castrillon Solange Kimie Ikeda 
Published: January 2025

Objective: To evaluate the effect of different substrates and the use of foliar fertilizer on the growth of M. guianensis seedlings in nursery conditions in order to indicate the ideal one for their development.

Method: Three types of substrate were used: 100% black soil (TP); 100% soil from the area where the species occurs (TO); 100% Vivatto® commercial substrate (CS). A 2x3 factorial experimental design was adopted. Finally, the parameters used to assess the growth of the seedlings were: height of the aerial part (H), diameter of the neck (DC) and number of leaves of each seedling (NF).

Results and conclusion: The results obtained showed significant differences in the characteristics of height and number of leaves in Mouriri guianensis seedlings, with the 100% Vivatto® commercial substrate treatment. There were no significant differences in the use of foliar fertilizer.

Implications of the research: The Mouriri guianensis species is extremely important as it provides food for fish and birds, has medicinal uses and is recommended for recovering degraded areas. It is therefore important to obtain information on its production, as well as to assess the quality of the seedlings in alternative substrates.

Originality/value: describe the study's contribution to the advancement of science in the field and/or socio-environmental management practices in organizations, in line with the scope of the RGSA.
Effectiveness of pulmonary function test as elective module among undergraduate medical students
Authors: Chowdhury Debanjana , Datta Arunima 
Published: January 2025

Objectives:
We selected pulmonary function test (PFT), a widely used investigation for diagnosis and monitoring of patients having respiratory complaints in Block I (preclinical) Physiology as an elective module since exposure of undergraduate medical students to PFT is inadequate in formal medical training. The elective module in medical curriculum was introduced by national medical commission (NMC) to provide ample opportunity to the students to opt for any course of their choice not covered by traditional syllabus. This will help them to enhance their knowledge, skill, lateral thinking, creativity, experiential learning, communication ability, team-based collaborative learning thus developing their personal and professional confidence in dealing with resource-limited unfavorable circumstances. Hence we introduced this elective to sensitize the future physicians about the importance of PFT, attract their interest in the subject of Physiology and motivate them to choose Physiology as a career preference.

Materials and Methods:
A quasi-experimental study was conducted in the Department of Physiology to create a time-bound activity schedule on the implementation of PFT as an elective module on 32 Phase III part I M.B.B.S students. We assessed the improvement in knowledge and skill by comparing pre-test and post-test results. We have used the Kirkpatrick evaluation model Level 1 to record the reaction of the students and Level 2 to evaluate their confidence regarding PFT after the course. Thematic analysis was performed on the perception and feedback of students and faculties.

Results:
We observed that all 32 participating students showed statistically significant (P < 0.0001) improvement in both knowledge gain and skill development. This course helped them increase their confidence to perform PFT independently on patients, interpreting reports, diagnosing various respiratory diseases and enabling them to apply this knowledge to manage the clinical cases in the hospital wards and in the emergency department. Thematic analysis of responses of students pointed out the strengths, weaknesses and suggestions for betterment of the module. The SWOT (Strengths, Weaknesses, Opportunities,Threats) analysis of the perception of faculties guided us to devise a modified framework for the implementation of the PFT module in the future.

Conclusion:
The elective module on PFT was implemented successfully in our institution with a positive impact on students, assisting them to progress from basic comprehension of the physiology of lung mechanics to independent interpretation of PFT reports to utilising PFT in clinical reasoning and decision-making.
Modulatory effect of quercetin on aspirin-induced hepatoxicity in Wistar rats
Authors: Akingbade Modupe Adebanji , Adegoke-Kehinde Olamide , Faeji Charles Oluwafemi , Fasoro Ayodeji 
Published: January 2025

Objectives:
Aspirin, also known as acetylsalicylic acid, is a non-steroidal anti-inflammatory drug medication. Aspirin has been shown to have a wide range of pharmacological effects, such as antipyretic, antiplatelet and analgesic effects. Although there is little known about how aspirin causes hepatotoxicity at the cellular level, this does happen and there is a need to look into some hepatoprotective remedies. The aim of this study was to assess how quercetin (QE) affects aspirin-induced hepatotoxicity in Wistar rats.

Materials and Methods:
Thirty-five male adult Wistar rats divided into seven experimental groups were used in this study. These groups received different treatments: Some were given varying concentrations of QE (30 mg/kg and 60 mg/kg), while others received aspirin (50 mg/kg). In addition, there were control groups that did not receive either aspirin or QE, with normal saline and corn oil being administered instead. The administration of treatments lasted for 30 days, after which the experiment was concluded, and the rats’ livers were removed for histological examination. Simultaneously, blood serum samples were collected for the biochemical analysis of liver enzyme markers. The level of significance was set at 0.05, and the data collected was analysed using the Statistical Package for the Social Sciences version 29.

Results:
It was found that aspirin increased the level of liver enzyme markers in the serum after 30 days of administration resulting from damage to the liver cells, this effect was most significant at an aspirin concentration of 50 mg/kg and QE at a concentration of 60 mg/kg was most effective in exhibiting hepatoprotective potentials.

Conclusion:
The results suggest that aspirin 50 mg/kg could be hepatotoxic due to the lessening of antioxidant effects, and QE has a modulating effect on aspirin-induced toxicity.
МЕТОДИКА КАЛИБРОВКИ ВОЛОКОННО-ОПТИЧЕСКОГО РЕФРАКТОМЕТРИЧЕСКОГО ДАТЧИКА
Authors: МУРАШКИНА Т И. , БАДЕЕВ В А. , БАДЕЕВА Е А. , СЕРЕБРЯКОВ Д И. 
Published: January 2025

Для обеспечения точности измерения показателей преломления жидкостей, качество которых определяется, все рефрактометрические средства измерений (РСИ) проходят процедуру калибровки для снижения погрешности градуирования, которая составляет до 70 % основной погрешности. В отдельных случаях требуется проводить процедуру калибровки в идеальных условиях, не допуская резких перепадов температуры, так как у жидкостей при повышении температуры значение показателя преломления уменьшается, а при понижении - увеличивается. Сложность и большая длительность процедуры калибровки снижает ценность известных РСИ. Цель исследования - снижение основной погрешности нового волоконно-оптического рефрактометрического датчика (ВОРД), реализующего модифицированный рефрактометрический способ диагностики качества жидкостных сред различного применения. Результаты. Доказано, что применение сначала прозрачного калибровочного вещества с известным коэффициентом преломления, помещенного в цилиндрическую прозрачную микротрубку, а потом прозрачного исследуемого вещества с искомым коэффициентом преломления, позволяет изменить контур изображения излучающего торца подводящего оптического волокна в плоскости, где расположены приемные торцы отводящих оптических волокон, и, соответственно, изменить выходной сигнал датчика...
To ensure the accuracy of measuring the refractive indices of liquids, the quality of which is determined, all refractometric measuring instruments (RMI) undergo a calibration procedure to reduce the calibration error, which is up to 70 % of the basic error. In some cases, it is necessary to carry out the calibration procedure under ideal conditions, avoiding sudden temperature changes, since the refractive index of liquids decreases with increasing temperature, and increases with decreasing temperature. The complexity and long duration of the calibration procedure reduces the value of the known RMI. The aim of the study is to reduce the basic error of the new fiber-optic refractometric sensor (FORS), which implements a modified refractometric method for diagnosing the quality of liquid media of various applications. Results. It is proved that the use of first a transparent calibration substance with a known refractive index placed in a cylindrical transparent microtubule, and then a transparent test substance with the desired refractive index, allows you to change the contour of the image of the radiating end of the incoming optical fiber in the plane where the receiving ends of the outgoing optical fibers are located, and, accordingly, change the output signal of the sensor...