bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anisotropy of the Near‐Field Coseismic Ionospheric Perturbation Amplitudes Reflecting the Source Process: The 2023 February Turkey Earthquakes
Authors: Bagiya Mala S. , Heki K. , Gahalaut Vineet K. 
Published: July 2023

AbstractThe East Anatolian Fault in southern Turkey ruptured on 6 February 2023, causing a Mw 7.8 earthquake (EQ1), one of the largest strike‐slip events recorded on land. ∼9 hr later, earthquake of Mw 7.7 (EQ2) occurred to the north of EQ1. We investigate here near‐field coseismic ionospheric perturbations (CIP) caused by acoustic waves (AWs) excited by coseismic vertical crustal movements. We find that observed CIP periods were somewhat longer for EQ1 than EQ2. EQ1 also showed azimuthal dependence in CIP amplitudes that cannot be explained by known factors such as geomagnetism and line‐of‐sight geometry. Numerical experiments revealed that CIP by EQ1 can be well reproduced by assuming a suite of sources along the fault that successively ruptured. Small but significant dependence of amplitudes and periods on azimuths were caused by interference of AWs from multiple sources. We also found that CIP amplitudes of strike‐slip earthquakes tend to be lower than dip‐slip earthquakes.
Relict and Modern Sediments on the Continental Shelf of the Northern South China Sea: A Reconsideration
Authors: Wang Yuming , Chen Xiaohong , Switzer Adam D. , Li Linlin , Xu Yang , Wang Yukun , Zhang Peizhen 
Published: July 2023

AbstractUnderstanding the temporal‐spatial patterns of modern and relict sediments is of importance for assessing changes in the Quaternary environment and sea‐level. Sedimentological and geochemical data is presented, along with in situ shell‐based accelerator mass spectrometry 14C ages of 30 samples from the surface sediments on the northern shelf of the South China Sea (NSSCS). The authors’ data show that the NSSCS surface sediments exhibit considerable diversity in composition. Modern sediments are primarily constrained to the NW inner shelf, which is fed by fluvial sands sourced from Coastal South China river systems and dominated by the Pearl River Estuary delivery. The transport and discharge of the terrestrial sediments to the NSSCS is highly influenced by the Guangdong Longshore Current and its secondary cyclonic eddies. Relict sediments dominated by well‐sorted, medium‐ and coarse‐grained sands were identified in the NW Shenhu and NW Dongsha areas of the outer NSSCS. The sedimentology and geochemistry of the relict sediments imply that they were deposited in a dry and cold environment either during the low sea levels of the late Pleistocene (∼40 ka) or the early Holocene (∼10 ka). To the east, the Taiwan Shoal and vicinity are dominated by a sand mixture, at which the relict sediments were reworked by terrigenous supply and modern hydrodynamic environment due to the compound action of the Guangdong Longshore Current, seasonal cyclones, and Kuroshio Intrusion. The present isobaths of ∼−90 m in the NSSCS might be the reflective of the early Holocene coastal delta or the last glacial maximum shoreline.
Extreme Value Analysis of Ground Magnetometer Observations at Valentia Observatory, Ireland
Authors: Fogg Alexandra Ruth , Jackman C. M. , Malone‐Leigh J. , Gallagher P. T. , Smith A. W. , Lester M. , Walach M.‐T. , Waters J. E. 
Published: July 2023

AbstractUnderstanding global space weather effects is of great importance to the international scientific community, but more localized space weather predictions are important on a national level. In this study, data from a ground magnetometer at Valentia Observatory is used to characterize space weather effects on the island of Ireland. The horizontal component of magnetometer observations and its time derivative are considered, and extreme values of these are identified. These extremes are fit to a generalized extreme value distribution, and from this model return values (the expected magnitude of an observation within a given time window) are predicted. The causes of extreme values are investigated both in a case study, and also statistically by looking at contributions from geomagnetic storms, substorms, and sudden commencements. This work characterizes the extreme part of the distribution of space weather effects on Ireland (and at similar latitudes), and hence examines those space weather observations which are likely to have the greatest impact on susceptible technologies.
Enhancement of the SESN2-SHP cascade by melatonin ameliorates hepatic gluconeogenesis by inhibiting the CRBN-BTG2-CREBH signaling pathway
Authors: An Seungwon , Nedumaran Balachandar , Koh Hong , Joo Dong Jin , Lee Hyungjo , Park Chul-Seung , Harris Robert A. , Shin Keong Sub , Djalilian Ali R. , Kim Yong Deuk 
Published: July 2023

AbstractMelatonin is involved in the regulation of various biological functions. Here, we explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protects against fasting- and diabetes-mediated hepatic glucose metabolism. Various key gene expression analyses were performed and multiple metabolic changes were assessed in liver specimens and primary hepatocytes of mice and human participants. The expression of the hepatic cereblon (CRBN) and b-cell translocation gene 2 (BTG2) genes was significantly increased in fasting mice, diabetic mice, and patients with diabetes. Overexpression of Crbn and Btg2 increased hepatic gluconeogenesis by enhancing cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH), whereas this phenomenon was prominently ablated in Crbn null mice and Btg2-silenced mice. Interestingly, melatonin-induced SESN2 and SHP markedly reduced hepatic glucose metabolism in diabetic mice and primary hepatocytes, and this protective effect of melatonin was strikingly reversed by silencing Sesn2 and Shp. Finally, the melatonin-induced SESN2-SHP signaling pathway inhibited CRBN- and BTG2-mediated hepatic gluconeogenic gene transcription via the competition of BTG2 and the interaction of CREBH. Mitigation of the CRBN-BTG2-CREBH axis by the melatonin-SESN2-SHP signaling network may provide a novel therapeutic strategy to treat metabolic dysfunction due to diabetes.
All-cause and cause-specific mortality among people with bipolar disorder: a large-scale systematic review and meta-analysis
Authors: Biazus Taís Boeira , Beraldi Gabriel Henrique , Tokeshi Lucas , Rotenberg Luísa de Siqueira , Dragioti Elena , Carvalho André F. , Solmi Marco , Lafer Beny 
Published: July 2023

Abstract
Objective
Bipolar disorder (BD) is associated with premature mortality. All-cause and specific mortality risks in this population remain unclear, and more studies are still needed to further understand this issue and guide individual and public strategies to prevent mortality in bipolar disorder Thus, a systematic review and meta‐analysis of studies assessing mortality risk in people with BD versus the general population was conducted. The primary outcome was all‐cause mortality, whilst secondary outcomes were mortality due to suicide, natural, unnatural, and specific‐causes mortality.

Results
Fifty-seven studies were included (BD; n = 678,353). All‐cause mortality was increased in people with BD (RR = 2.02, 95% CI: 1.89–2.16, k = 39). Specific‐cause mortality was highest for suicide (RR = 11.69, 95% CI: 9.22–14.81, k = 25). Risk of death due to unnatural causes (RR = 7.29, 95% CI: 6.41–8.28, k = 17) and natural causes (RR = 1.90, 95% CI: 1.75–2.06, k = 17) were also increased. Among specific natural causes analyzed, infectious causes had the higher RR (RR = 4,38, 95%CI: 1.5–12.69, k = 3), but the analysis was limited by the inclusion of few studies. Mortality risk due to respiratory (RR = 3.18, 95% CI: 2.55–3.96, k = 6), cardiovascular (RR = 1.76, 95% CI: 1.53–2.01, k = 27), and cerebrovascular (RR = 1.57, 95% CI: 1.34–1.84, k = 13) causes were increased as well. No difference was identified in mortality by cancer (RR = 0.99, 95% CI: 0.88–1.11, k = 16). Subgroup analyses and meta-regression did not affect the findings.

Conclusion
Results presented in this meta-analysis show that risk of premature death in BD is not only due to suicide and unnatural causes, but somatic comorbidities are also implicated. Not only the prevention of suicide, but also the promotion of physical health and the prevention of physical conditions in individuals with BD may mitigate the premature mortality in this population. Notwithstanding this is to our knowledge the largest synthesis of evidence on BD-related mortality, further well-designed studies are still warranted to inform this field.
A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant
Authors: Pettitt Stephen J. , Shao Nan , Zatreanu Diana , Frankum Jessica , Bajrami Ilirjana , Brough Rachel , Krastev Dragomir B. , Roumeliotis Theodoros I. , Choudhary Jyoti S. , Lorenz Sonja , Rust Alistair , de Bono Johann S. , Yap Timothy A. , Tutt Andrew N. J. , Lord Christopher J. 
Published: July 2023

AbstractAlthough PARP inhibitors (PARPi) now form part of the standard-of-care for the treatment of homologous recombination defective cancers, de novo and acquired resistance limits their overall effectiveness. Previously, overexpression of the BRCA1-∆11q splice variant has been shown to cause PARPi resistance. How cancer cells achieve increased BRCA1-∆11q expression has remained unclear. Using isogenic cells with different BRCA1 mutations, we show that reduction in HUWE1 leads to increased levels of BRCA1-∆11q and PARPi resistance. This effect is specific to cells able to express BRCA1-∆11q (e.g. BRCA1 exon 11 mutant cells) and is not seen in BRCA1 mutants that cannot express BRCA1-∆11q, nor in BRCA2 mutant cells. As well as increasing levels of BRCA1-∆11q protein in exon 11 mutant cells, HUWE1 silencing also restores RAD51 nuclear foci and platinum salt resistance. HUWE1 catalytic domain mutations were also seen in a case of PARPi resistant, BRCA1 exon 11 mutant, high grade serous ovarian cancer. These results suggest how elevated levels of BRCA1-∆11q and PARPi resistance can be achieved, identify HUWE1 as a candidate biomarker of PARPi resistance for assessment in future clinical trials and illustrate how some PARPi resistance mechanisms may only operate in patients with particular BRCA1 mutations.
Water in the terrestrial planet-forming zone of the PDS 70 disk
Authors: Perotti G. , Christiaens V. , Henning Th. , Tabone B. , Waters L. B. F. M. , Kamp I. , Olofsson G. , Grant S. L. , Gasman D. , Bouwman J. , Samland M. , Franceschi R. , van Dishoeck E. F. , Schwarz K. , Güdel M. , Lagage P.-O. , Ray T. P. , Vandenbussche B. , Abergel A. , Absil O. , Arabhavi A. M. , Argyriou I. , Barrado D. , Boccaletti A. , Caratti o Garatti A. , Geers V. , Glauser A. M. , Justannont K. , Lahuis F. , Mueller M. , Nehmé C. , Pantin E. , Scheithauer S. , Waelkens C. , Guadarrama R. , Jang H. , Kanwar J. , Morales-Calderón M. , Pawellek N. , Rodgers-Lee D. , Schreiber J. , Colina L. , Greve T. R. , Östlin G. , Wright G. 
Published: July 2023

AbstractTerrestrial and sub-Neptune planets are expected to form in the inner (less than 10 au) regions of protoplanetary disks1. Water plays a key role in their formation2–4, although it is yet unclear whether water molecules are formed in situ or transported from the outer disk5,6. So far Spitzer Space Telescope observations have only provided water luminosity upper limits for dust-depleted inner disks7, similar to PDS 70, the first system with direct confirmation of protoplanet presence8,9. Here we report JWST observations of PDS 70, a benchmark target to search for water in a disk hosting a large (approximately 54 au) planet-carved gap separating an inner and outer disk10,11. Our findings show water in the inner disk of PDS 70. This implies that potential terrestrial planets forming therein have access to a water reservoir. The column densities of water vapour suggest in-situ formation via a reaction sequence involving O, H2 and/or OH, and survival through water self-shielding5. This is also supported by the presence of CO2 emission, another molecule sensitive to ultraviolet photodissociation. Dust shielding, and replenishment of both gas and small dust from the outer disk, may also play a role in sustaining the water reservoir12. Our observations also reveal a strong variability of the mid-infrared spectral energy distribution, pointing to a change of inner disk geometry.
A novel intra-tumoral drug delivery carrier for treatment of oral squamous cell carcinoma
Authors: Elsaady Shimaa A. , Aboushelib Moustafa N. , Al-Wakeel Essam , Badawi Manal F. 
Published: July 2023

AbstractThe treatment of oral squamous cell carcinoma (OSCC) includes systemic chemotherapy and is associated with aggressive side effects on patients. This study evaluated a new intra-tumor-targeted drug delivery method for the treatment of OSCC induced on the dorsum of the tongue in white mice. The induced tumors were examined by needle biopsy. A targeted anticancer drug (Cetuximab) and [Cisplatin and 5 Fluorouracil (5-FU)] chemotherapeutic agents were loaded on polyethylene glycol-polylactide-polyethylene glycol (PEG-PLA-PEG) nanoparticles (NPs) designed for intralesional injection while systemic administration was used as control. Fourier transform infrared spectroscopy (FTIR) was performed to study NP chemical structure, a drug release profile was conducted to study release kinetics, and histopathological evaluation was performed before and after treatment to evaluate tissue reactions (n-28, ά = 0.05). The drug release profile was characteristic of the chemotherapeutic agent showing early quick ascend followed by sustained slow release. FTIR peaks identified the polymeric structure of the drug nano-carrier. Histopathologic examination of chemically induced OSCC revealed different grades ranging from non-invasive to invasive stages of OSCC. Intra-tumoral test group revealed significant remission of observed cancer grade compared to the systemically administered group (X2 = 12.63, P < 0.001). Finally, using synthesized PEG–PLA–PEG NPs for intralesional injection is a promising route for the treatment of OSCC.
Evidence of familial resemblance and family-based heritability of food intakes derived from a longitudinal cohort study
Authors: Akbarzadeh Mahdi , Teymoori Farshad , Riahi Parisa , Farhadnejad Hossein , Ahmadirad Hamid , Sadat Zahedi Asiyeh , Hosseini-Esfahani Firoozeh , Zarkesh Maryam , Vafa Mohammadreza , Mirmiran Parvin , Daneshpour Maryam S. 
Published: July 2023

AbstractWe sought to investigate the familial aggregation and family-based heritability of dietary intakes among adults in a population-based longitudinal study of the Tehran Lipid and Glucose Study (TLSG). Total of 4359 males and 5439 females entered our study. We categorized foods into main groups based on the literature on main food groups and their subgroups among the Iranian dietary habits and food culture as follows: grains, fruits, vegetables, dairy, meats, legume, nuts, beverages, snacks, and fats. The intraclass correlation coefficients (ICC) are estimated to verify familial resemblance of dietary habits for all relative pairs and spouses. Family-based heritability is obtained using a mixed effect framework with likelihood-based approach. For almost all food groups, the correlation between parents and offsprings tended to be larger than those of siblings. Family-based heritability of food groups varies from the lowest 6.36% for snacks to the highest 25.67% for fruits, and 25.66% for legume. Our findings indicated weak-to-moderate similarities between parents' and offspring's food intakes; however, the similarity in parent–child food intakes was different, and the correlation in mother-daughter food intakes was stronger than other parent–child correlations, and almost all of dietary components showed strong family-based heritability.
Evidences for the augmented Cd(II) biosorption by Cd(II) resistant strain Candida tropicalis XTA1874 from contaminated aqueous medium
Authors: Bhattacharyya Kaustav , Bhattacharjee Neelanjan , Ganguly Subhadeep 
Published: July 2023

AbstractCadmium is one of the most dreadful heavy metals and is becoming a major toxicant in ground water with increasing concentration above the WHO Guidelines in drinking water (0.003 mg/L). The potential sources of cadmium include sewage sludge, phosphate fertilizers and ingredients like Ni–Cd batteries, pigments, plating and plastics. Cadmium levels are increased in water owing to the use and disposal of cadmium containing ingredients. Water draining from a landfill may contain higher cadmium levels. The authors have tried to evaluate the optimized nutritional conditions for the optimal growth and Cd(II) remediation capacity for a developed Cd(II) resistant yeast strain named Candida tropicalis XTA 1874 isolated from contaminated water-body in West Bengal. By analyzing the optimization conditions, a synthetic medium was developed and the composition has been given in the main text. The strain showed much better Cd(II) adsorption capacity under the optimized nutritional conditions (Mean removal = 88.077 ± 0.097%).
Electrophysiological damage to neuronal membrane alters ephaptic entrainment
Authors: Cunha Gabriel Moreno , Corso Gilberto , Lima Marcelo M. S. , dos Santos Lima Gustavo Zampier 
Published: July 2023

AbstractThe brain is commonly understood as a complex network system with a particular organization and topology that can result in specific electrophysiological patterns. Among all the dynamic elements resulting from the circuits of the brain’s network, ephapticity is a cellular communication mechanism that has received little attention. To understand the network’s properties of ephaptic entrainment, we start investigating the ephaptic effect on a single neuron. In this study, we used numerical simulations to examine the relationship between alterations in ephaptic neuronal entrainment and impaired electrophysiological properties of the neuronal membrane, which can occur via spike field coherence (SFC). This change in frequency band amplitude is observed in some neurodegenerative diseases, such as Parkinson’s or Alzheimer’s. To further investigate these phenomena, we proposed a damaged model based on the impairment of both the resistance of the ion channels and the capacitance of the lipid membrane. Therefore, we simulated ephaptic entrainment with the hybrid neural model quadratic integrate-and-fire ephaptic (QIF-E), which mimics an ephaptic entrainment generated by an LFP (simulate a neuronal group). Our results indicate a link between peak entrainment (ephapticity) preference and a shift in frequency band when damage occurs mainly in ion channels. Finally, we discuss possible relationships between ephaptic entrainment and neurodegenerative diseases associated with aging factors.
Efficient removal of pharmaceutical contaminants from water and wastewater using immobilized laccase on activated carbon derived from pomegranate peels
Authors: Al-sareji Osamah J. , Meiczinger Mónika , Al-Juboori Raed A. , Grmasha Ruqayah Ali , Andredaki Manolia , Somogyi Viola , Idowu Ibijoke A. , Stenger-Kovács Csilla , Jakab Miklós , Lengyel Edina , Hashim Khalid S. 
Published: July 2023

AbstractIn this study, pomegranate peels (PPs) as an abundant fruit processing waste was used to produce cost-effective, eco-friendly, and high-quality activated carbon. The produced carbon (fossil free activated carbon) was used for immobilizing laccase to remove a range of emerging pollutants namely diclofenac, amoxicillin, carbamazepine, and ciprofloxacin from water and wastewater. The loaded activated carbon by laccase (LMPPs) and the unloaded one (MPPs) were characterized using advanced surface chemistry analysis techniques. MPPs was found to have a porous structure with a large surface area and an abundance of acidic functional groups. Laccase immobilization reduced surface area but added active degradation sites. The optimal immobilization parameters were determined as pH 4, 35 °C, and a laccase concentration of 2.5 mg/mL resulting in a 69.8% immobilization yield. The adsorption of the emerging pollutant onto MPPs is best characterized as a spontaneous endothermic process that adheres to the Langmuir isotherm and first-order kinetics. Using synergistic adsorption and enzymatic degradation, the target pollutants (50 mg/L) were eliminated in 2 h. In both water types, LMPPs outperformed MPPs. This study shows that pomegranate peels can effectively be harnessed as an enzyme carrier and adsorbent for the removal of emerging pollutants even from a complex sample matrix. The removal of contaminants from wastewater lasted five cycles, whereas it continued up to six cycles for water.
Validation of bone mineral density measurement using quantitative CBCT image based on deep learning
Authors: Park Chan-Soo , Kang Se-Ryong , Kim Jo-Eun , Huh Kyung-Hoe , Lee Sam-Sun , Heo Min-Suk , Han Jeong-Joon , Yi Won-Jin 
Published: July 2023

AbstractThe bone mineral density (BMD) measurement is a direct method of estimating human bone mass for diagnosing osteoporosis, and performed to objectively evaluate bone quality before implant surgery in dental clinics. The objective of this study was to validate the accuracy and reliability of BMD measurements made using quantitative cone-beam CT (CBCT) image based on deep learning by applying the method to clinical data from actual patients. Datasets containing 7500 pairs of CT and CBCT axial slice images from 30 patients were used to train a previously developed deep-learning model (QCBCT-NET). We selected 36 volumes of interest in the CBCT images for each patient in the bone regions of potential implants sites on the maxilla and mandible. We compared the BMDs shown in the quantitative CBCT (QCBCT) images with those in the conventional CBCT (CAL_CBCT) images at the various bone sites of interest across the entire field of view (FOV) using the performance metrics of the MAE, RMSE, MAPE (mean absolute percentage error), R2 (coefficient of determination), and SEE (standard error of estimation). Compared with the ground truth (QCT) images, the accuracy of the BMD measurements from the QCBCT images showed an RMSE of 83.41 mg/cm3, MAE of 67.94 mg/cm3, and MAPE of 8.32% across all the bone sites of interest, whereas for the CAL_CBCT images, those values were 491.15 mg/cm3, 460.52 mg/cm3, and 54.29%, respectively. The linear regression between the QCBCT and QCT images showed a slope of 1.00 and a R2 of 0.85, whereas for the CAL_CBCT images, those values were 0.32 and 0.24, respectively. The overall SEE between the QCBCT images and QCT images was 81.06 mg/cm3, whereas the SEE for the CAL_CBCT images was 109.32 mg/cm3. The QCBCT images thus showed better accuracy, linearity, and uniformity than the CAL_CBCT images across the entire FOV. The BMD measurements from the quantitative CBCT images showed high accuracy, linearity, and uniformity regardless of the relative geometric positions of the bone in the potential implant site. When applied to actual patient CBCT images, the CBCT-based quantitative BMD measurement based on deep learning demonstrated high accuracy and reliability across the entire FOV.