bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies
Authors: McNicholas Bairbre A. , Rezoagli Emanuele , Simpkin Andrew J. , Khanna Sankalp , Suen Jacky Y. , Yeung Pauline , Brodie Daniel , Li Bassi Gianluigi , Pham Tai , Bellani Giacomo , Fraser John F. , Laffey John ,   on behalf of the CCCC Consortium
Published: January 2023

AbstractBackgroundAcute kidney injury (AKI) is a frequent and severe complication of both COVID-19-related acute respiratory distress syndrome (ARDS) and non-COVID-19-related ARDS. The COVID-19 Critical Care Consortium (CCCC) has generated a global data set on the demographics, management and outcomes of critically ill COVID-19 patients. The LUNG-SAFE study was an international prospective cohort study of patients with severe respiratory failure, including ARDS, which pre-dated the pandemic.MethodsThe incidence, demographic profile, management and outcomes of early AKI in patients undergoing invasive mechanical ventilation for COVID-19-related ARDS were described and compared with AKI in a non-COVID-19-related ARDS cohort.ResultsOf 18,964 patients in the CCCC data set, 1699 patients with COVID-19-related ARDS required invasive ventilation and had relevant outcome data. Of these, 110 (6.5%) had stage 1, 94 (5.5%) had stage 2, 151 (8.9%) had stage 3 AKI, while 1214 (79.1%) had no AKI within 48 h of initiating invasive mechanical ventilation. Patients developing AKI were older and more likely to have hypertension or chronic cardiac disease. There were geo-economic differences in the incidence of AKI, with lower incidence of stage 3 AKI in European high-income countries and a higher incidence in patients from middle-income countries. Both 28-day and 90-day mortality risk was increased for patients with stage 2 (HR 2.00,p < 0.001) and stage 3 AKI (HR 1.95,p < 0.001). Compared to non-COVID-19 ARDS, the incidence of shock was reduced with lower cardiovascular SOFA score across all patient groups, while hospital mortality was worse in all groups [no AKI (30 vs 50%), Stage 1 (38 vs 58%), Stage 2 (56 vs 74%), and Stage 3 (52 vs 72%),p < 0.001]. The time profile of onset of AKI also differed, with 56% of all AKI occurring in the first 48 h in patients with COVID-19 ARDS compared to 89% in the non-COVID-19 ARDS population.ConclusionAKI is a common and serious complication of COVID-19, with a high mortality rate, which differs by geo-economic location. Important differences exist in the profile of AKI in COVID-19 versus non-COVID-19 ARDS in terms of their haemodynamic profile, time of onset and clinical outcomes.
Comparison of high-flow nasal cannula and conventional oxygen therapy for high-risk patients during bronchoscopy examination: protocol for a randomized controlled trial
Authors: Qin Hao , Jing Guo-Qiang , Tan Wei , Wang Jun , Yin Yi-Nan , Chen Rong-Zhang , Zhang Wei , Li Jie 
Published: January 2023

Abstract

Introduction
High-flow nasal cannula (HFNC) has been proven to improve oxygenation and avoid intubation in hypoxemic patients. It has also been utilized during endoscopy examination to reduce the incidence of hypoxia. However, little is known about the effects of HFNC versus conventional oxygen therapy (COT) on oxygenation during bronchoscopy examination via nasal route; particularly, no study has compared the use of HFNC with that of COT at similar FIO2 for patients who have high-risk factors of desaturation during bronchoscopy examination.

Methods and analysis
This randomized controlled trial will be implemented in four academic centers in China. Patients who have high-risk factors including hypoxemia, hypercapnia, morbid obesity, and narrow airway will be enrolled to use HFNC or COT during bronchoscopy examination. In the HFNC group, the initial gas flow will be set at 50 L/min with a fraction of inspired oxygen (FIO2) at 0.45, if the patient tolerates, the flow can be increased to 60L/min at most, while in the COT group, oxygen flow will be set at 6 L/min via a conventional nasal cannula. After 5 min pre-oxygenation, the bronchoscope will be inserted via the nasal route. Vital signs, oxygenation (SpO2), and transcutaneous CO2 (PtCO2) will be continuously monitored. The primary outcome is the incidence of hypoxemia, defined as SpO2 < 90% for 10 s during bronchoscopy examination, and secondary outcomes include the need for treatment escalation and adverse events.

Discussion
Hypoxia is a common complication of bronchoscopy, our study attempted to demonstrate that HFNC may reduce the probability of hypoxia during bronchoscopy in high-risk patients. The results will be disseminated through peer-reviewed journals and national and international conferences.

Trial registration
http://www.chictr.org.cn/: ChiCTR2100055038. Registered on 31 December 2021.
The reporting requirements of case reports and adherence of case report reporting guidelines in medical journals: an analysis of the authors’ guide sections
Authors: Taheri Abolfazl , Adibi Peyman , Sabbagh Jafari Mojtaba , Saeedizadeh Marzieh , Rahimi Alireza , Abbasi Alireza 
Published: January 2023

Abstract
Background
Owing to the growth of case reports and changes in the policy of journals in publishing this evidence, the need to standardize them is felt more than before. Therefore, in this study, the authors’ guide of medical journals indexed in the Scopus database that published most of the case reports has been analyzed to identify the reporting requirements and emerging case report types.

Methods
A total of 50 journals were selected from the Scopus citation database (the world’s largest knowledge base) that published most of the case reports. These and the authors’ guideline section on the types and requirements of writing case reports were analyzed by inductive content analysis.

Results
Most of the case reports were published in the fields of dermatology and surgery and general medicine. Reporting requirements in author’s guide are grouped in four categories: (1) reasons for publication or content value, (2) emphasis on the patient consent form and confidentiality, (3) emphasizing the constraints on the word count and limitation, and (4) recommendation for structure and reporting elements. In terms of adherence to the reporting guidelines, 76% of journals do not adhere to any reporting guideline. In addition, 13 types of case reports were identified in these journals, among which traditional case reports, clinical image, letters, and case series were the most widely used formats.

Conclusions
Improving the publication processes of case reports has been left unattended by international organizations. The policies of journals need to become more integrated, and reporting guidelines should be modified or redeveloped to enhance the quality of publications, cover different reporting requirements, and consequently, benefit from the evidence value available in case reports.
Reversible designs for extreme memory cost reduction of CNN training
Authors: Hascoet Tristan , Febvre Quentin , Zhuang Weihao , Ariki Yasuo , Takiguchi Tetsuya 
Published: January 2023

AbstractTraining Convolutional Neural Networks (CNN) is a resource-intensive task that requires specialized hardware for efficient computation. One of the most limiting bottlenecks of CNN training is the memory cost associated with storing the activation values of hidden layers. These values are needed for the computation of the weights’ gradient during the backward pass of the backpropagation algorithm. Recently, reversible architectures have been proposed to reduce the memory cost of training large CNN by reconstructing the input activation values of hidden layers from their output during the backward pass, circumventing the need to accumulate these activations in memory during the forward pass. In this paper, we push this idea to the extreme and analyze reversible network designs yielding minimal training memory footprint. We investigate the propagation of numerical errors in long chains of invertible operations and analyze their effect on training. We introduce the notion of pixel-wise memory cost to characterize the memory footprint of model training, and propose a new model architecture able to efficiently train arbitrarily deep neural networks with a minimum memory cost of 352 bytes per input pixel. This new kind of architecture enables training large neural networks on very limited memory, opening the door for neural network training on embedded devices or non-specialized hardware. For instance, we demonstrate training of our model to 93.3% accuracy on the CIFAR10 dataset within 67 minutes on a low-end Nvidia GTX750 GPU with only 1GB of memory.
A lived experience response to the proposed diagnosis of terminal anorexia nervosa: learning from iatrogenic harm, ambivalence and enduring hope
Authors: Elwyn Rosiel 
Published: January 2023

AbstractThe ethical approach to treatment non-response and treatment refusal in severe-enduring anorexia nervosa (SE-AN) is the source of significant ethical debate, particularly given the risk of death by suicide or medical complications. A recent article proposed criteria to define when anorexia nervosa (AN) can be diagnosed as ‘terminal’ in order to facilitate euthanasia or physician-assisted suicide (EAS), otherwise known as medical assistance in dying, for individuals who wish to be relieved of suffering and accept treatment as ‘futile’. This author utilises their personal lived experience to reflect on the issues raised, including: treatment refusal, iatrogenic harm, suicidality and desire to end suffering, impact of diagnosis/prognosis, schemas, alexithymia, countertransference, ambivalence, and holding on to hope. Within debates as critical as the bioethics of involuntary treatment, end-of-life and EAS in eating disorders, it is crucial that the literature includes multiple cases and perspectives of individuals with SE-AN that represent a wide range of experiences and explores the complexity of enduring AN illness, complex beliefs, communication patterns and relational dynamics that occur in SE-AN.
The computational thinking for science (CT-S) framework: operationalizing CT-S for K–12 science education researchers and educators
Authors: Hurt Timothy , Greenwald Eric , Allan Sara , Cannady Matthew A. , Krakowski Ari , Brodsky Lauren , Collins Melissa A. , Montgomery Ryan , Dorph Rena 
Published: January 2023

AbstractContemporary science is a field that is becoming increasingly computational. Today’s scientists not only leverage computational tools to conduct their investigations, they often must contribute to the design of the computational tools for their specific research. From a science education perspective, for students to learn authentic science practices, students must learn to use the tools of the trade. This necessity in science education has shaped recent K–12 science standards including the Next Generation Science Standards, which explicitly mention the use of computational tools and simulations. These standards, in particular, have gone further and mandated that computational thinking be taught and leveraged as a practice of science. While computational thinking is not a new term, its inclusion in K–12 science standards has led to confusion about what the term means in the context of science learning and to questions about how to differentiate computational thinking from other commonly taught cognitive skills in science like problem-solving, mathematical reasoning, and critical thinking. In this paper, we propose a definition of computational thinking for science (CT-S) and a framework for its operationalization in K–12 science education. We situate our definition and framework in Activity Theory, from the learning sciences, in order to position computational thinking as an input to and outcome of science learning that is mediated by computational tools.
Comment on “Spatial changes in inclusion band spacing as an indicator of temporal changes in slow slip and tremor recurrence intervals” by Nishiyama et al.
Authors: Williams Randolph T. 
Published: January 2023

AbstractA recent paper by Nishiyama et al. (Earth, Planets, and Space 73:126) examined syntectonic quartz veins to constrain temporal variations in the recurrence intervals between slow slip and tremor events. The authors claim that by examining the liquid-volume fraction of syntectonic fluid inclusions in the veins, that they can accurately reconstruct pore-fluid pressures (and variations therein) that were operative during faulting at ~ 15 km depth in an exhumed subduction melange. From these observations, the authors infer that large (from lithostatic to hydrostatic) decreases in pore-fluid pressure occurred during faulting, and that these variations drove increases in supersaturation and rapid quartz precipitation over time scales consistent with the repeat times of seismologically observed slow slip and tremor events. Here, I show that Nishiyama et al.’s analysis neglects reasonable uncertainties in pore-fluid pressure reconstruction. When those uncertainties are included, the Nishiyama et al.’s results become ambiguous as to whether any variation in pore-fluid pressure during vein formation occurred at all, negating the validity of many of the subsequent conclusions.
Graphical Abstract
Childhood trauma, perceived stress and anhedonia in individuals at clinical high risk for psychosis: multigroup mediation analysis
Authors: O'Brien Kathleen J. , Ered Arielle , Korenic Stephanie A. , Olino Thomas M. , Schiffman Jason , Mittal Vijay A. , Ellman Lauren M. 
Published: January 2023

BackgroundEvidence suggests that both childhood trauma and perceived stress are risk factors for the development of psychosis, as well as negative symptoms such as anhedonia. Previous findings link increases in perceived stress to anhedonia in individuals at clinical high risk for psychosis (CHR) and depression; however, the role of childhood trauma in this relationship has not yet been explored, despite consistent evidence that it is associated with sensitisation to later stress.AimsTo examine whether perceived stress mediates the relationship between childhood trauma and anhedonia in a group of youth at CHR as well as in controls (groups with depression and with no diagnosed mental health concerns).MethodThe study used multigroup mediation to examine the indirect effects of childhood trauma on anhedonia via perceived stress in CHR (n = 117) and depression groups (n = 284) and non-psychiatric controls (n = 124).ResultsPerceived stress mediated the relationship between childhood trauma and consummatory anhedonia regardless of group status. Perceived stress mediated the relationship between childhood trauma and anticipatory anhedonia for the CHR and depression groups, but not for non-psychiatric controls. Further, groups differed in the magnitude of this relationship, with the effects trending towards stronger for those in the CHR group.ConclusionsOur findings suggest a potential transdiagnostic pathway through which childhood trauma contributes to anhedonia across severe mental illness.
Adaptive exit facilitates the evolution of cooperation in the spatial prisoner's dilemma game with punishment
Authors: Wang Wei , He Zhixue , Li Xiaogang , Shi Lei 
Published: January 2023

Abstract
The enforcement of costly punishment can facilitate cooperation. However, it is unclear how punishment would influence cooperation if individuals are free to exit an interaction. In this work, individuals are allowed to exit with a certain probability, which is adaptively adjusted based on the difference between expectations and payoffs. According to simulation results, adaptive exit can significantly improve cooperation even when punishment is weak; moreover, there is an optimal level of aspiration that causes adaptive exit to best promote the evolution of cooperation. Because of reciprocity, cooperative individuals maintain the lowest level of exit probability, allowing the relationship between them to be maintained, and the interaction between cooperative individuals and defectors is affected by adaptive exit processing, which is related to aspiration levels. Results show that cooperation prevails under moderate aspiration levels, because the exit mechanism protects cooperative individuals from exploitation by defectors; however, the exit mechanism does not prevent the invasion of cooperators by defectors when the aspiration level is low. The negative impact of sanctions causes defectors to increase their exit probability, and the exit of the defectors prevents nearby punishers from exploitation as well as reduces the implementation of punishment, thereby easing the punishment burden on the punisher. Therefore, the adaptive exit mechanism helps to eliminate second-order free-riding at a lower aspiration level. The study identifies the significant effects of exit on punishment, and highlights the important role of their association in the evolution of cooperation.
Dorsal aorta polarization and haematopoietic stem cell emergence
Authors: Yvernogeau Laurent , Dainese Giovanna , Jaffredo Thierry 
Published: January 2023

ABSTRACT
Recent studies have highlighted the crucial role of the aorta microenvironment in the generation of the first haematopoietic stem cells (HSCs) from specialized haemogenic endothelial cells (HECs). Despite more than two decades of investigations, we require a better understanding of the cellular and molecular events driving aorta formation and polarization, which will be pivotal to establish the mechanisms that operate during HEC specification and HSC competency. Here, we outline the early mechanisms involved in vertebrate aorta formation by comparing four different species: zebrafish, chicken, mouse and human. We highlight how this process, which is tightly controlled in time and space, requires a coordinated specification of several cell types, in particular endothelial cells originating from distinct mesodermal tissues. We also discuss how molecular signals originating from the aorta environment result in its polarization, creating a unique entity for HSC generation.
A member of the claudin superfamily influences formation of the front domain in pheromone-responding yeast cells
Authors: Sukumar Madhushalini , DeFlorio Reagan , Pai Chih-Yu , Stone David E. 
Published: January 2023

ABSTRACT
Cell polarization in response to chemical gradients is important in development and homeostasis across eukaryota. Chemosensing cells orient toward or away from gradient sources by polarizing along a front–rear axis. Using the mating response of budding yeast as a model of chemotropic cell polarization, we found that Dcv1, a member of the claudin superfamily, influences front–rear polarity. Although Dcv1 localized uniformly on the plasma membrane (PM) of vegetative cells, it was confined to the rear of cells responding to pheromone, away from the pheromone receptor. dcv1Δ conferred mislocalization of sensory, polarity and trafficking proteins, as well as PM lipids. These phenotypes correlated with defects in pheromone-gradient tracking and cell fusion. We propose that Dcv1 helps demarcate the mating-specific front domain primarily by restricting PM lipid distribution.
Dynamics of intracellular cGMP during chemotaxis in Dictyostelium cells
Authors: Yumura Shigehiko , Nakano Masaki , Honda Aika , Hashimoto Yuuki , Kondo Tomo 
Published: January 2023

ABSTRACT
Cyclic guanosine 3′,5′-monophosphate (cGMP) is a ubiquitous important second messenger involved in various physiological functions. Here, intracellular cGMP (cGMPi) was visualized in chemotactic Dictyostelium cells using the fluorescent probe, D-Green cGull. When wild-type cells were stimulated with a chemoattractant, fluorescence transiently increased, but guanylate cyclase-null cells did not show a change in fluorescence, suggesting that D-Green cGull is a reliable indicator of cGMPi. In the aggregation stage, the responses of cGMPi propagated in a wave-like fashion from the aggregation center. The oscillation of the cGMPi wave was synchronized almost in phase with those of other second messengers, such as the intracellular cAMP and Ca2+. The phases of these waves preceded those of the oscillations of actomyosin and cell velocity, suggesting that these second messengers are upstream of the actomyosin and chemotactic migration. An acute increase in cGMPi concentration released from membrane-permeable caged cGMP induced a transient shuttle of myosin II between the cytosol and cell cortex, suggesting a direct link between cGMP signaling and myosin II dynamics.
The effect of using chondroitin sulfate in osteoarthritis of the knee
Authors: Żaba Ziemowit , Lisowska Aleksandra , Żołyniak Wojciech , Warzyszak Paweł , Małek Róża , Milczek Maria , Hawranik Izabela , Tomasik Mikołaj , Niski Szymon , Skrzypek Mateusz 
Published: January 2023

Introduction: Osteoarthritis is the most common disease of the musculoskeletal system. It develops in the regulation of the quality and quantity of articular cartilage, which cushions the joint and improves the sliding of the articular surfaces. Chondroitin sulfate being a natural glycosaminoglycan is found in the cartilage and extracellular matrix. The European League Against Rheumatism (EULAR) recommends the use of chondroitin sulfate in the treatment of knee osteoarthritis.

Objective: The purpose of our study was to present, based on the available literature, the latest reports on the effect of chondroitin sulfate in knee osteoarthritis

Methods and materials: The present study was based on available data collected in the PubMed database and published between 2001 and 2022. The study was conducted by reviewing keywords such as: ,,knee osteoarthritis”, ,,chondroitin sulfate”, ,,treatment” ,,diagnosis”

State of knowledge: Joint cartilage is mainly composed of type II collagen, proteoglycans, chondrocytes and water. In healthy articular cartilage, the balance between the individual components is constantly maintained, thanks to which cartilage degradation is accompanied by its synthesis. The reviewed scientific papers evaluated the effect of chondroitin sulfate on pain in osteoarthritis.

Summary: We found a large inconsistency between experimental protocols and study results. Therefore, comparing publications evaluating the actual effect of chondroitin sulfate on joint synovial tissues and biochemical markers is challenging. Additional studies are needed focusing on long-term treatment as well as evaluating their potential disease modifying effects.