bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of head movements in gaze tracking during table tennis forehand stroke
Authors: Shinkai Ryosuke , Ando Shintaro , Nonaka Yuki , Yoshimura Yusei , Kizuka Tomohiro , Ono Seiji 
Published: March 2023

AbstractThe purpose of this study was to clarify the properties of gaze and head movements during forehand stroke in table tennis. Collegiate table tennis players (n = 12) conducted forehand strokes toward a ball launched by a skilled experimenter. A total of ten trials were conducted for the experimental task. Horizontal and vertical movements of the ball, gaze, head and eye were analyzed from the image recorded by an eye tracking device. The results showed that participants did not always keep their gaze and head position on the ball throughout the entire ball path. Our results indicate that table tennis players tend to gaze at the ball in the initial ball-tracking phase. Furthermore, there was a significant negative correlation between eye and head position especially in the vertical direction. This result suggests that horizontal VOR is relatively suppressed than vertical VOR in ball-tracking during table tennis forehand stroke. Finally, multiple regression analysis showed that the contribution of head position to gaze position was significantly higher than that of eye position. This result indicates that gaze position during forehand stroke could be associated with head position rather than eye position. Taken together, head movements may play an important role in maintaining the ball in a constant egocentric direction in table tennis forehand stroke.
Adrenal extramedullary hematopoiesis as an inducible model of the adult hematopoietic niche
Authors: Schyrr Frédérica , Alonso-Calleja Alejandro , Vijaykumar Anjali , Gebhard Sandra , Sarkis Rita , Lopes Silvia F. , Oggier Aurélien , De Leval Laurence , Nombela-Arrieta César , Naveiras Olaia 
Published: March 2023

AbstractHematopoietic Stem and Progenitor Cells (HSPCs) reside in the hematopoietic niche, a structure that regulates the balance of cellular quiescence, self-renewal and commitment in a demand-adapted manner. The bone marrow (BM) hematopoietic niche is formed by several cellular players, mainly endothelial cells, osteoblasts, adipocytes, and stromal cells. While the BM niche forms a complex structure, evidence exists for simpler, albeit functional, extramedullary hematopoietic niches. However, the composition of what constitutes the simplest unit of an HSPC supportive microenvironment remains largely unknown. Here, we show that the adult adrenal gland can be transformed into a hematopoietic supportive environment. Upon splenectomy and hormonal stimulation, the adult adrenal gland can be induced to recruit and host HSPC function, including serial transplantation. Furthermore, the adrenal stroma contains a CXCL12+ population, reminiscent of BM CXCL12-Abundant Reticular (CAR) cells. Mirroring this, we found CXCL12+ cells in patient samples obtained from a local cohort of myelolipoma, a benign adrenal tumor composed of adipose and hematopoietic tissue that constitutes the most common site of extramedullary hematopoiesis specific to the adult. We present our model as a novel tool to increase our understanding of the physiology of hematopoietic support and to facilitate the development of a boneless niche model.
Primate Cerebellar Scaling in Connection to the Cerebrum: A 34-Species Phylogenetic Comparative Analysis
Authors: Magielse Neville , Toro Roberto , Steigauf Vanessa , Abbaspour Mahta , Eickhoff Simon B. , Heuer Katja , Valk Sofie L. 
Published: March 2023

AbstractThe cerebellum has increasingly been recognized for its role in diverse functional processes. The reciprocally connected cerebello-cerebral system may scaffold both brain size increase and advanced associative abilities, evolving highly coordinately in primates. In parallel, functional cerebello-cerebral modules have undergone reorganization and cerebellar lobules crura I-II (the ansiform area across mammals) have been reported to be specifically expanded in humans. Here we manually segmented 63 cerebella (34 primate species; 9 infraorders) and 30 crura I-II (13 species; 8 infraorders). We show that both constraints and reorganization may shape the evolution of the primate cerebello-cerebral system. Using phylogenetic generalized least squares, we find that the cerebellum scales isometrically with the cerebral cortex, whereas crura I-II scale hyper-allometrically versus both. Our phylogenetic analyses evidence primate-general crura I-II hyperscaling in contrast to virtually isometric cerebello-cerebral scaling. Crura I-II hyperscaling may be important for associative and cognitive brain functions in an evolutionary context.
Intracellular biotransformation and disposal mechanisms of magnetosomes in macrophages and cancer cells
Authors: Gandarias L. , Gubieda A.G. , Gorni G. , Mathon O. , Olivi L. , Abad-Díaz-de-Cerio Ana , Fdez-Gubieda M.L. , Muela A. , García-Prieto A. 
Published: March 2023

AbstractMagnetosomes are magnetite nanoparticles biosynthesized by magnetotactic bacteria. Given their potential clinical applications for the diagnosis and treatment of cancer, it is essential to understand what becomes of them once they are within the body. With this aim, here we have followed the intracellular long-term fate of magnetosomes in two cell types: cancer cells (A549 cell line), because they are the actual target for the therapeutic activity of the magnetosomes, and macrophages (RAW 264.7 cell line), because of their role at capturing foreign agents. We show that cells dispose of magnetosomes using three mechanisms: splitting them into daughter cells, excreting them to the surrounding environment, and degrading them yielding less or non-magnetic iron products. A deeper insight into the degradation mechanisms by means of time-resolved X-ray absorption near-edge structure (XANES) spectroscopy has allowed us to follow the intracellular biotransformation of magnetosomes by identifying and quantifying the iron species occurring during the process. In both cell types there is a first oxidation of magnetite to maghemite and then, earlier in macrophages than in cancer cells, ferrihydrite starts to appear. Given that ferrihydrite is the iron mineral phase stored in the cores of ferritin proteins, this suggests that cells use the iron released from the degradation of magnetosomes to load ferritin. Comparison of both cellular types evidences that macrophages are more efficient at disposing of magnetosomes than cancer cells, attributed to their role in degrading external debris and in iron homeostasis.Graphical Abstract
Sublethal heat reduces overall reproductive investment and male allocation in a simultaneously hermaphroditic snail species
Authors: van Dijk Shanna , Zizzari Valentina , Koene Joris M. , Nakadera Yumi 
Published: March 2023

AbstractA well-known effect of sub-lethal temperature exposure in a diversity of species is a decrease in reproductive performance. Although this effect has been particularly emphasized for males or male reproductive functioning, it remains to be firmly demonstrated that the effect of heat on fertility is sex-specific. To contribute to this question, here we examined the impact of sub-lethally high temperature on male and female functions in a simultaneously hermaphroditic snail species,Lymnaea stagnalis. Examining hermaphrodites is useful to evaluate the sex-specific impacts of heat exposure, since they possess male and female functions within a single individual, sharing genetic and environmental factors. Moreover, previously developed sex allocation theory allows us to compare the differential performance of sex functions. In this study, we exposed snails to temperatures ranging from 20 to 28 °C for 14 days and assessed their egg and sperm production, sperm transfer, mating behaviour and growth. Both types of gamete production were significantly reduced by higher temperature, leading to an overall reduction of reproductive investment. By quantifying sex allocation, we furthermore revealed that the heat-stressed snails reduced the relative investment in their male function. In addition, even though sperm production and its transfer were drastically decreased by high temperature, male mating motivation was not affected. This study illustrates that examining simultaneous hermaphrodites can provide significant insights for the impact of heat, and the proximate mechanism, on reproduction in wildlife.
Threat specificity in fear appeals: examination of fear response and motivated behavior
Authors: Sobol Kamila , Giroux Marilyn 
Published: March 2023

Purpose
A fear appeal is a communication tactic designed to scare people into adopting desired behaviors (e.g. wash hands to avoid contracting COVID-19). While it is generally acknowledged that fear appeals can be persuasive at motivating behavior, this paper aims to identify how to optimally identify how to optimally frame the focal threat to increase their effectiveness as well as to uncover additional underlying processes.

Design/methodology/approach
The authors conducted four experimental studies.

Findings
This research validates that exposure to fear appeals can strongly motivate behavior. However, this study shows that this effect is moderated by threat specificity. Specifically, this study demonstrates that people are more motivated to engage in behaviors that facilitate threat avoidance after exposure to a personally relevant threat that represents a nonspecific (e.g. aging appearance) rather than a specific outcome (e.g. wrinkles). This effect is mediated by perceptions of assimilation (versus contrast) to the focal threat. This study reliably shows the effect across three threat domains (i.e. aging appearance, weight gain, illness) and for different behaviors.

Originality/value
Theoretically speaking, this study contributes to the fear appeal literature by identifying a new type of message framing that has the potential to increase fear appeal’s persuasive power, and uncovering a distinct mechanism by which fear appeals impact behavior. Practically speaking, the findings confirm that fear appeals have the potential to help marketers mobilize consumer behavior, especially when the communication highlights a nonspecific rather than specific threat.
Piperacillin/tazobactam versus carbapenems in patients with severe bacterial infections: A systematic review with meta‐analysis
Authors: Munch Marie Warrer , Granholm Anders , Jonsson Andreas Bender , Sjövall Fredrik , Helleberg Marie , Hertz Frederik Boëtius , Andersen Jakob Steen , Steensen Morten , Achiam Michael Patrick , Perner Anders , Møller Morten Hylander 
Published: March 2023

AbstractBackgroundPiperacillin/tazobactam or meropenem are often used to treat patients with severe bacterial infections. We aimed to compare the desirable and undesirable effects of empirical and/or definitive piperacillin/tazobactam versus carbapenems in patients with severe bacterial infections.MethodsWe searched PubMed, Embase, CENTRAL, Epistemonikos, and trial registers for randomised clinical trials of empirical and/or definitive piperacillin/tazobactam versus carbapenems in adult patients with severe bacterial infection (i.e., any bacterial infection requiring hospitalisation). The primary outcome was all‐cause short‐term mortality within 90 days. Secondary outcomes were all‐cause long‐term mortality, adverse events, quality of life, days alive without or duration of life support, secondary infections, selection of fungi or resistant bacteria, and days alive and out of hospital or hospital length of stay. We calculated relative risks (RRs) using random effects and fixed effect meta‐analyses along with trial sequential analyses.ResultsWe included 31 trials (n = 8790 patients) with overall high risk of bias. The RR for all‐cause short‐term mortality was 1.16 (95% confidence interval [CI]: 0.94–1.43, low certainty evidence), for adverse events 1.00 (98% CI: 0.96–1.04, moderate certainty evidence), for secondary infections 1.13 (98% CI: 0.76–1.68, very low certainty evidence), and for selection of fungi or resistant bacteria 1.61 (98% CI: 0.89–2.89, very low certainty evidence). There were no or limited data for the remaining outcomes.ConclusionsBased on very low or low certainty evidence, piperacillin/tazobactam may be associated with less favourable outcomes in patients with severe bacterial infections as compared with carbapenems, but the information size for a robust conclusion has not been reached.
Theory‐based behaviour change intervention to promote mental health help‐seeking among older adults in Australia: Initial dissemination and acceptability
Authors: Adams Claire , Gringart Eyal , Strobel Natalie 
Published: March 2023

AbstractObjectiveRates of help‐seeking for mental health problems among older adults are low and initiatives to increase help‐seeking in older populations are limited. To our knowledge, no interventions have aimed to promote help‐seeking among older adults by tapping internal motivations to seek help. In this paper, we describe the development of a theory‐based intervention designed to promote mental health help‐seeking among older adults in Australia, using an internal motivation paradigm.MethodsThe intervention was co‐designed through a consultative process with nine key stakeholders who represented five main groups: primary health‐care providers, mental health professionals, health‐care executives, community organisations and consumers. Development was an iterative process, based on best practice guidelines. Nineteen older adults (≥65 years) provided feedback on the acceptability of the intervention.ResultsThe intervention consisted of a help‐seeking brochure with behaviour change messages based on the Theory of Planned Behaviour (TPB). Messages targeted older adults' attitudes towards help‐seeking, subjective norms, perceived behavioural control and barriers to seeking help. Most participants (74%) responded with agree/strongly agree to 10 items measuring the acceptability of the intervention, indicating the intervention is relevant, clear, appropriate and appealing.ConclusionsThe present intervention appears to be an acceptable way to promote help‐seeking for mental health problems among older adults. A larger, robust trial is warranted to determine the effectiveness of the intervention in improving help‐seeking attitudes, intentions and behaviour. The intervention has the potential to increase older adults' engagement with mental health support and improve health outcomes in this population.
Palm live aboveground biomass in the riparian zones of a forest in Central Amazonia
Authors: Falen Lourdes , Guedes Mariane , de Castilho Carolina V. , Jorge Rafael F. , Bezerra Francisco M. , Magnusson William E. 
Published: March 2023

AbstractAboveground biomass estimates in the Amazon region remain uncertain, partly due to extrapolations based mainly on samples collected in upland terrains of terra‐firme forests. Most biomass estimates were focused on dicotyledonous trees or included other plant groups as a category of trees. Palms dominate areas that represent 20% of the Brazilian Amazon. However, their contribution to biomass estimates and the variation within riparian zones remain poorly documented. We estimated the biomass of palms larger than 1–cm diameter at breast height (1.3 m aboveground) in riparian plots (n = 40); investigated the potential bias caused by the use of dicotyledonous‐ or family‐ rather than species‐level equations for biomass estimation; compared palm biomass between riparian and non‐riparian plots (n = 72); and evaluated the effects of soil, topography, and stream characteristics in riparian plots on palm biomass. Mean palm biomass in riparian zones estimated with species‐level equations (27.50 ± 12.94 Mg/ha, range: 3.32–63.27 Mg/ha) was three times greater than biomass estimated with a family‐level equation (9.04 ± 4.29 Mg/ha, range: 1.51–21.25 Mg/ha) and was greater than mean biomass estimated with a pantropical equation (20.46 ± 9.29 Mg/ha, range: 3.67–47.99 Mg/ha). Mean palm biomass in riparian zones was four times greater than in non‐riparian zones. Palm biomass was high in flatter areas with poorly drained soils, but lower around streams with higher discharge. Inclusion of palms can contribute to reducing the uncertainties in biomass estimates in Amazonian forests. Recognition of the importance of riparian zones may improve conservation policies.Abstract in Portuguese is available with online material.
A score for predicting invasive pulmonary aspergillosis in immunocompetent critically ill patients
Authors: Li Wen , Chen Gang , Lin Fengyu , Yang Hang , Cui Yanhui , Lu Rongli , Song Chao , Li Haitao , Li Yi , Pan Pinhua 
Published: March 2023

AbstractBackgroundDelayed treatment leads to increased mortality in critically ill patients with invasive pulmonary aspergillosis (IPA). We aimed to develop and validate a prediction score based on novel biomarkers and clinical risk factors to identify IPA in immunocompetent patients in the intensive care unit (ICU).MethodsA retrospective study was conducted to collect medical information and novel biomarkers upon ICU admission. Risk factors adopted for the final prediction score were identified using multivariate logistic regression analysis.ResultsWe retrospectively collected 1841 critical ill patients between January 2018 and August 2022. Patients with IPA had higher C‐reactive protein‐to‐albumin ratio (CAR), neutrophil‐to‐lymphocyte ratio, systemic immune‐inflammation index and lower prognostic nutritional index (PNI). Chronic obstructive pulmonary disease (COPD), continuous renal replacement therapy (CRRT), high dose of corticosteroids, broad‐spectrum antibiotics, blood galactomannan (GM) positivity and high CAR were independent risk factors for IPA and were entered into the final prediction score. The score had good discrimination, with the area under receiver operating characteristic curve of 0.816 and 0.780 for the training and validation cohorts, respectively, and good calibration.ConclusionA score based on six clinical and novel immunological biomarkers showed promising predictive value for antifungal treatment in immunocompetent ICU patients.
Expert consensus established around flexible, individualized migraine treatment utilizing a modified Delphi panel
Authors: Graf Marlon , Kim Edward , Brewer Iris , Hernandez Jennifer , Chou Jacquelyn W. , Cirillo Jessica , Jensen Christopher , Lipton Richard 
Published: March 2023

AbstractObjectiveTo characterize treatment decision‐making processes and formalize consensus regarding key factors headache specialists consider in treatment decisions for patients with migraine, considering novel therapies.BackgroundMigraine therapies have long been subject to binary classification, acute versus preventive, due to limitations of available drugs. The emergence of novel therapies that can be used more flexibly creates an opportunity to rethink this binary classification. To determine the role of these novel therapies in treatment, it is critical to understand whether existing guidelines reflect clinical practice and to establish consensus around factors driving management.MethodsA three‐round modified Delphi process was conducted with migraine clinical experts. Round 1 consisted of an online questionnaire; Round 2 involved an online discussion of aggregated Round 1 results; and Round 3 allowed participants to revise Round 1 responses, incorporating Round 2 insights. Questions elicited likelihood ratings (0 = highly unlikely to 100 = highly likely), rankings, and estimates on treatment decision‐making.ResultsNineteen experts completed three Delphi rounds. Experts strongly agreed on definitions for “acute” (median = 100, inter‐quartile range [IQR] = 5) and “preventive” treatment (median = 90, IQR = 15), but noted a need for treatment customization for patients (median = 100, IQR = 6). Experts noted certain aspects of guidelines may no longer apply based on established tolerability and efficacy of newer acute and preventive agents (median = 91, IQR = 17). Further, experts agreed on a treatment category referred to as “situational prevention” (or “short‐term prevention”) for patients with reliable and predictable migraine triggers (median = 100, IQR = 10) or time‐limited periods when headache avoidance is important (median = 100, IQR = 12).ConclusionsUsing the modified Delphi method, a panel of migraine experts identified the importance of customizing treatment for people with migraine and the utility of “situational prevention,” given the ability of new treatment options to meet this need and the potential to clinically identify patients and time periods when this approach would add value.
RETRACTED: The outcome of prolonged postoperative antibiotics on wound healing in orthognathic surgery: A meta‐analysis
Authors: Lu Ying , Li Jian 
Published: March 2023

AbstractWe conducted a meta‐analysis to assess the outcome of prolonged postoperative antibiotics (PA) on wound healing in orthognathic surgery (OS). A systematic literature search up to January 2023 was performed and 1021 related studies were evaluated. The chosen studies comprised 1057 OS subjects who participated in the selected studies' baseline, 446 of them used short‐term PA, and 611 used long‐term PA. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated to assess the effect of prolonged PA on wound infection after OS by the dichotomous methods with a random or fixed effect model. The short‐term PA resulted in significantly higher wound infection (OR, 4.27; 95% CI, 2.97–6.14, P < 0.001) with low heterogeneity (I2 = 27%) compared to the long‐term PA in OS. The short‐term PA resulted in significantly higher wound infection compared to the long‐term PA in OS. Though care should be taken when dealing with the results since a large number of the selected studies had <100 subjects as a sample size.
BDH1 promotes lung cancer cell proliferation and metastases by PARP1‐mediated autophagy
Authors: Zhang Zhimin , Bi Xin , Lian Xiaojuan , Niu Zhongxi 
Published: March 2023

AbstractLymph node metastases and distant metastases were the important limiting factor for therapy of unresectable locally advanced (IIIB stage) and oligotransduction (IVa stage) lung cancer. This study was undertaken to identify a novel predictive biomarker for predicting lymph node metastases of lung cancer. A total of 364 patients with lung cancer which comprised of 198 patients with transcriptome sequencing data, 110 cases with immunohistochemistry data and 66 patients with serum samples were included to identify and validate the candidate gene. Autophagy was measured by western blots, immunofluorescence and electron microscope. We found that 3‐hydroxybutyrate dehydrogenase 1 (BDH1) was associated with proliferation and metastases of lung cancer. BDH1 expression in both tissue and serum samples was associated with lung cancer metastases. Mechanical studies revealed that the AMPK‐mTOR signalling pathway mediated by PARP1 played an important role in BDH1‐induced autophagy. Activation of mTOR pathway markedly increased the effect of BDH1 in cell proliferation and metastases. These results were verified by the knockdown of PARP1. Furthermore, in vivo administration of BDH1 effectively promoted tumour growth in H460 xenografts mice. Our finding not only suggested that BDH1 might be useful as a novel biomarker and therapeutic target for lung cancer metastases, but also imply that PARP1‐mediated AMPK‐mTOR signalling pathway might play a critical role in BDH1‐induced autophagy and lung cancer proliferation and metastases.