bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of active biocomposite films based on poly(lactic acid) and wine by‐product: Effect of grape pomace content and extrusion temperature
Authors: Bruna Julio E. , Castillo Mario , López de Dicastillo Carol , Muñoz‐Shugulí Cristina , Lira Marcia , Guarda Abel , Rodríguez‐Mercado Francisco J. , Galotto María J. 
Published: July 2023

AbstractThis work aims to evaluate the effect of the extrusion temperature of poly(lactic acid) (PLA) with different grape pomace (GP) content for the development of active biocomposite films. Two different GP concentrations (10 and 15 wt.%) were used to obtain GP/PLA composites through extrusion at three different temperature profiles. The biocomposites were characterized through optical, thermal, structural, and mechanical tests. In addition, the antimicrobial and antioxidant capacity of materials were evaluated. Results showed GP antioxidant components are stable up to 180°C. The incorporation of GP in PLA resulted in red‐color films with a high color difference (ΔE > 30). The glass transition, cold crystallization, and melting temperatures as well as the tensile strength of PLA decreased by increasing GP concentration in the films; however, elastic modulus and elongation at break increased. The biocomposite with lowest GP content had better antimicrobial activity against Escherichia coli and Listeria innocua. Contrary, 15% GP/PLA composite showed the highest antioxidant activity. Nevertheless, high extrusion temperature profile reduced the bioactivity of materials due to the GP degradation. These results showed the feasibility and best extrusion temperature profile to develop active materials using wine by‐products, which could be applied as active food packaging.
CO2 Adsorption on Pore‐Engineered Carbons Derived from Jute Sticks
Authors: Hanif Aamir , Aziz Md. Abdul , Helal Aasif , Abdelnaby Mahmoud M. , Qasem Mohammed Ameen Ahmed , Khan Abuzar , Hakeem Abbas S. , Al‐Betar Abdul‐Rahman F. , Khan Mohd Yusuf 
Published: July 2023

AbstractCO2 capture is a practical approach to mitigating the impacts of global warming. Adsorption‐based carbon capture is a clean and potentially energy‐efficient method whose performance greatly depends on adsorbent design. In this study, we explored the use of jute‐derived carbon as a high‐performance adsorbent for CO2 capture. The carbons were produced by pyrolyzing powdered jute sticks with NaHCO3 as an activating agent at 500–700 °C. Impressive adsorption capacities of up to 2.5 mmol ⋅ g−1 and CO2/N2 selectivities of up to 54 were achieved by adjusting the pore size distribution and surface functionalization. Based on the isotherm results, the working capacities, regenerabilities, and potentials for CO2 separation were determined for a practical vacuum swing adsorption process. The adsorbent materials were characterized by XRD, FTIR, Raman, FESEM and N2 sorption at 77 K. This study provides a general approach for designing adsorbents for various gas‐separation applications.
A longitudinal study of sibling bullying and mental health in autistic adolescents: The role of self‐esteem
Authors: Deniz Emre , Toseeb Umar 
Published: July 2023

AbstractSibling bullying is associated with poor mental health in autistic adolescents. The reasons for this remain unknown. In the current study, we attempted to replicate the existing findings on the direct associations between sibling bullying and mental health in autistic adolescents and expand knowledge by focusing on the indirect associations through self‐esteem. We made use of existing data from the Millennium Cohort Study, a nationally representative UK‐based birth cohort study. We fitted a mediation model to longitudinal data from a sample of 416 autistic adolescents aged 11, 14, and 17 years old who had at least one sibling. We found that sibling bullying was prevalent in the lives of autistic adolescents, especially in those who were late‐diagnosed, had a shared bedroom, and lived in a low‐income household. Additionally, increased sibling bullying in early adolescence was a significant predictor of reduced self‐esteem in mid‐adolescence; in turn, reduced self‐esteem predicted poorer mental health and wellbeing in late adolescence. Our findings indicate that sibling bullying in early adolescence may indirectly lead to poorer mental health and wellbeing in late adolescence through a reduction in self‐esteem in mid‐adolescence in autistic adolescents. We discuss the implications of these findings further.
Supply chain system for a centralized biorefinery system based on switchgrass grown on marginal land in Michigan
Authors: Kim Seungdo , Dale Bruce E. , Basso Bruno , Thelen Kurt , Maravelias Christos T. 
Published: July 2023

AbstractThe feedstock supply chain of a biorefinery is critical in determining the economic and environmental performance of biofuels. This study investigated various feedstock supply chains for a centralized biorefinery based on different objective functions and how the biorefinery responds to supply chain volatility. For the analysis, a hypothetical centralized biorefinery was supplied by switchgrass grown on marginal lands in Michigan. From an economic standpoint, the minimum biofuel selling price is an important metric of the objective function, and the greenhouse gas mitigation potential is a similarly important metric for global warming impact. A trade‐off therefore exists between the economic and environmental performance of biofuels under this system configuration. However, when a carbon tax credit is applied to soil organic carbon sequestration in switchgrass production, the metric of the objective function may not be the key factor in establishing a supply chain as long as it is associated with biorefinery capacity as well as economic or environmental values. Year‐to‐year fluctuations in cellulosic biomass yield (supply chain volatility) might also prevent the biorefinery from operating at full capacity. Cellulosic biomass pellets can serve as an auxiliary feedstock for the centralized cellulosic biorefinery system to minimize the impacts of supply chain volatility.
Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome‐mediated endothelial cell pyroptosis
Authors: Zhang Xiaolu , Yang Qiuyue , Zhang Ruifeng , Zhang Yilin , Zeng Wenyun , Yu Qun , Zeng Miao , Gan Jiali , Li Huhu , Yang Lin , Gao Qing , Jiang Xijuan 
Published: July 2023

AbstractEndothelial pyroptosis promotes cerebral ischemia/reperfusion injury (CIRI). Sodium Danshensu (SDSS) has been shown to attenuate CIRI and have anti‐inflammatory properties in endothelial cells. However, the mechanism and effect of SDSS on alleviating endothelial pyroptosis after CIRI remains poorly understood. Thus, we aimed to investigate the efficacy and mechanism of SDSS in reducing endothelial pyroptosis. It has been shown that SDSS administration inhibited NLRP3 inflammasome‐mediated pyroptosis. As demonstrated by protein microarrays, molecular docking, CETSA and ITDRFCETSA, SDSS bound strongly to CLIC4. Furthermore, SDSS can decrease its expression and inhibit its translocation. Its effectiveness was lowered by CLIC4 overexpression but not by knockdown. Overall The beneficial effect of SDSS against CIRI in this study can be ascribed to blocking endothelial pyroptosis by binding to CLIC4 and then inhibiting chloride efflux‐dependent NLRP3 inflammasome activation.
Hybrid modeling in bioprocess dynamics: Structural variabilities, implementation strategies, and practical challenges
Authors: Mahanty Biswanath 
Published: July 2023

AbstractHybrid modeling, with an appropriate blend of the mechanistic and data‐driven framework, is increasingly being adopted in bioprocess modeling, model‐based experimental design (digital‐twin), identification of critical process parameters, and optimization. However, the development of a hybrid model from experimental data is an inherently complex workflow, involving designed experiments, selection of the data‐driven process, identification of model parameters, assessment fitness, and generalization capability. Depending on the complexity of the process system and purpose, each piece of these modules can flexibly be incorporated into the puzzle. However, this extra flexibility can be a cause of concern to trace an “optimal” model structure. In this paper, the development of hybrid models in a common bioprocess system, selection of data‐driven components and their mapping to states, choice of parameter identification techniques, and model quality assurance are revisited. The challenges associated with hybrid‐model development, and corrective actions have also been reviewed. The review also suggests the lack of data, and code sharing in communal repositories can be a hurdle in the exploration, and expansion of those tools in a bioprocess system.
A deep learning model using hyperspectral image for EUS‐FNA cytology diagnosis in pancreatic ductal adenocarcinoma
Authors: Qin Xianzheng , Zhang Minmin , Zhou Chunhua , Ran Taojing , Pan Yundi , Deng Yingjiao , Xie Xingran , Zhang Yao , Gong Tingting , Zhang Benyan , Zhang Ling , Wang Yan , Li Qingli , Wang Dong , Gao Lili , Zou Duowu 
Published: July 2023

AbstractBackground and AimsEndoscopic ultrasonography‐guided fine‐needle aspiration/biopsy (EUS‐FNA/B) is considered to be a first‐line procedure for the pathological diagnosis of pancreatic cancer owing to its high accuracy and low complication rate. The number of new cases of pancreatic ductal adenocarcinoma (PDAC) is increasing, and its accurate pathological diagnosis poses a challenge for cytopathologists. Our aim was to develop a hyperspectral imaging (HSI)‐based convolution neural network (CNN) algorithm to aid in the diagnosis of pancreatic EUS‐FNA cytology specimens.MethodsHSI images were captured of pancreatic EUS‐FNA cytological specimens from benign pancreatic tissues (n = 33) and PDAC (n = 39) prepared using a liquid‐based cytology method. A CNN was established to test the diagnostic performance, and Attribution Guided Factorization Visualization (AGF‐Visualization) was used to visualize the regions of important classification features identified by the model.ResultsA total of 1913 HSI images were obtained. Our ResNet18‐SimSiam model achieved an accuracy of 0.9204, sensitivity of 0.9310 and specificity of 0.9123 (area under the curve of 0.9625) when trained on HSI images for the differentiation of PDAC cytological specimens from benign pancreatic cells. AGF‐Visualization confirmed that the diagnoses were based on the features of tumor cell nuclei.ConclusionsAn HSI‐based model was developed to diagnose cytological PDAC specimens obtained using EUS‐guided sampling. Under the supervision of experienced cytopathologists, we performed multi‐staged consecutive in‐depth learning of the model. Its superior diagnostic performance could be of value for cytologists when diagnosing PDAC.
The Membrane Phospholipidomics Research of Oxidatively Damaged INS‐1 Pancreatic Beta Cells Intervened by the Effective Constituents of Anemarrhenae Asphodeloides Rhizoma
Authors: Xie Luming , Zhang Jing , Zeng Pingyan , Feng Yifan , Wu Xia 
Published: July 2023

AbstractThe rhizoma of Anemarrhenae asphodeloides has a long history of hypoglycemic use in Chinese traditional medicine. In this article, 400 μmol/L H2O2 induced normal INS‐1 pancreatic beta cells to establish experimental model of oxidative damage. Quercetin was used as a positive drug, and mangiferin and its ethanolic extract were selected as therapeutic agents in an oxidative damage model to evaluate the ameliorative effect of the active ingredients of Anemarrhenae asphodeloides rhizoma on oxidative damage in INS‐1 pancreatic β‐cells. Building a qualitative analysis method of membrane phospholipids of INS‐1 pancreatic beta cells and identified 82 phospholipids based on the UPLC/Q‐TOF MS technology, which could provide a database for further statistics analysis. OPLS‐DA was used to screen the phospholipid biomarkers from the raw data. Exploring the biological significances of these biomarkers, and discussing the toxic effect of the effective components of Anemarrhena asphodeloides rhizoma, on oxidatively damaged INS‐1 pancreatic beta cell.
Seasonal and Circadian Evaluation of the Essential Oil of Dizygostemon riparius (Plantaginaceae), a Wild Flavoring Herb from East Maranhão, Brazil
Authors: Galvão Francielton S. , da Rocha Cláudia Q. , Monteiro Odair S. , Figueiredo Pablo Luis B. , Santos Paulo Vinicius L. , Maia José Guilherme S. 
Published: July 2023

AbstractDizygostemon riparius (Plantaginaceae) is an aromatic herbal species known as “Melosa”, endemic to the Municipality of São Benedito do Rio Preto, East Maranhão state, Brazil. It has a refreshing and pleasant aroma and is used for food flavoring and controlling domestic animal parasites. This work aimed to evaluate the seasonal and circadian influence on the composition and production of essential oils (EOs) from D. riparius. The plant aerial parts were hydrodistilled, and the oils were analyzed by GC and GC/MS. The seasonal study was conducted from August 2019 to July 2020, and the circadian study in dry (November) and rainy (May) periods, at 6 am, 12 am, and 6 pm. The results showed that the medium EOs yield was 2.8 %, and the primary constituents (>2 %) were endo‐fenchyl acetate (30.5–42.1 %) and endo‐fenchol (31.6–37.4 %), (E)‐caryophyllene (2.8–7.6 %), α‐fenchene (3.3–6.5 %), p‐cymene (0.7–4.5 %), and caryophyllene oxide (1.4–2.7 %). Yield and composition of EOs did not significantly correlate with the climatic parameters, but their seasonal percentages influenced their two main components due to precipitation and solar radiation environmental factors. Quantitative variability in the EOs composition during the dry and rainy seasons was observed in the circadian period. These data may be significant for the plant's economic use.
Black Phosphorus as Promoter for Noble Metal‐Free Photocatalytic Hydrogen Production
Authors: Provinciali Giacomo , Filippi Jonathan , Lavacchi Alessandro , Caporali Stefano , Banchelli Martina , Serrano‐Ruiz Manuel , Peruzzini Maurizio , Caporali Maria 
Published: July 2023

AbstractPhotocatalysts which are stable to photocorrosion and noble metal‐free, are highly desirable to achieve a light‐driven hydrogen production which satisfies the criteria of low production cost and environmental sustainability. Herein, a new heterostructure TiO2/BP/CoP has been developed, in which the BP nanosheets interact strongly with TiO2 and CoP, speeding up the transfer of photogenerated electrons and thus increasing H2 production. Once BP is added to TiO2 (P25) as only 1 % wt., the H2 evolution rate increases up to 4 times reaching a value of 830 μmol/g ⋅ h under UV‐Vis light irradiation. By integrating CoP nanoparticles as a cocatalyst up to 2 % wt., H2 production is further promoted to 7400 μmol/g ⋅ h, 37 times higher than pristine TiO2. Photoluminescence and electrochemical impedance measurements show that this heterostructure achieves a much more efficient charge separation and reduction of the internal resistance in comparison to pristine TiO2. Combining these data with UV‐Vis diffuse reflectance and Mott‐Schottky, a plausible mechanism was proposed.
Synthesis of 2‐Trifluoromethyl‐4‐aminoquinolines via Heating‐Promoted Multi‐component Reaction of CF3‐Imidoyl Sulfoxonium Ylides and Amines with Difluorocarbene as a C1 Synthon†
Authors: Wei Guangming , Li Chen , Wang Haoyuan , Chen Zhengkai , Wu Xiao‐Feng 
Published: July 2023

Comprehensive SummaryA thermally‐induced multi‐component reaction of CF3‐substituted imidoyl sulfoxonium ylides (TFISYs), amines and (triphenylphosphonio)difluoroacetate (PDFA) has been developed, allowing a facile access to 2‐trifluoromethyl‐4‐aminoquinolines in high yields. The reaction proceeds smoothly with or without the addition of sulfur and utilizes difluorocarbene as a C1 synthon under simply heating conditions. Mechanistic study reveals thatin‐situgenerated thiocarbonyl fluoride, isothiocyanate orgem‐difluoroalkene might act as the key reaction intermediates.
Commentary on small‐volume biopsy of follicular lymphoma: Practical issues in the molecular era
Authors: Chen Chien‐Chin 
Published: July 2023

AbstractFollicular lymphoma (FL) is a common subtype of non‐Hodgkin lymphoma derived from germinal center B‐cells. Small‐volume biopsies (SVBs), including fine‐needle aspiration, needle core biopsy, and cell blocks, are often used for the assessment of patients with FL. Recently, Fitzpatrick et al. found that additional biopsies were frequently needed to supplement SVB for the initial diagnosis of FL. However, regardless of the type of SVB used, additional biopsies were usually not necessary for assessments for transformed or recurrent FL. Their multi‐institutional study reflects the fact that SVB may be sufficient for clinical decision‐making in these medical settings, although surgical excision is the gold standard for a definitive diagnosis of FL. With ancillary tests and advances in molecular testing, SVB has become increasingly popular and helpful, although there are practical limitations.
Sensitivity analysis of a multi‐physics model for the vascular microenvironment
Authors: Vitullo Piermario , Cicci Ludovica , Possenti Luca , Coclite Alessandro , Costantino Maria Laura , Zunino Paolo 
Published: July 2023

AbstractThe vascular microenvironment is the scale at which microvascular transport, interstitial tissue properties and cell metabolism interact. The vascular microenvironment has been widely studied by means of quantitative approaches, including multi‐physics mathematical models as it is a central system for the pathophysiology of many diseases, such as cancer. The microvascular architecture is a key factor for fluid balance and mass transfer in the vascular microenvironment, together with the physical parameters characterizing the vascular wall and the interstitial tissue. The scientific literature of this field has witnessed a long debate about which factor of this multifaceted system is the most relevant. The purpose of this work is to combine the interpretative power of an advanced multi‐physics model of the vascular microenvironment with state of the art and robust sensitivity analysis methods, in order to determine the factors that most significantly impact quantities of interest, related in particular to cancer treatment. We are particularly interested in comparing the factors related to the microvascular architecture with the ones affecting the physics of microvascular transport. Ultimately, this work will provide further insight into how the vascular microenvironment affects cancer therapies, such as chemotherapy, radiotherapy or immunotherapy.
Multiple load operation of indirect matrix converter for different frequencies using symmetrical space vector modulation
Authors: Ahmad Khanday Sajid , Hamid Bhat Abdul , Chandra Sekhar Obbu 
Published: July 2023

AbstractThis study describes an indirect matrix converter (IMC) that uses symmetrical space vector pulse width modulation (SSVPWM) to feed two loads from a single DC link at a variable frequency. Output stage‐I is connected to the static load, while output stage‐II is connected to the PMSM for speed control. It is appropriate for drive systems with variable frequency, such as those seen in wind power generation and aviation. In recent years, significant studies on AC‐AC converters have been conducted due to the rising interest in electric cars and renewable energy. The performance of permanent magnet motors is better than that of other types of AC motors due to their superior performance and residual flux permanent magnets. Contrary to normal back‐to‐back power conversion systems, IMC does not necessitate the use of capacitors in the DC‐link, decoupled control between the two‐stages, a simple clamping circuit or zero current switching in the rectifier stage, allowing the system's volume to be reduced. It is investigated how well the two output stages of the proposed IMC perform. To illustrate the benefits of the suggested IMC design, an improved SSVPWM is employed, and MATLAB/SIMULINK‐based simulations were performed to validate the efficacy of the modulation mechanism. In addition, the real‐time implementation of the work was validated using a real‐time simulator, OPAL‐RT (OP4510).
Effect of pulsed laser parameters on photoacoustic flow cytometry efficiency in vitro and in vivo
Authors: Grishin Oleg V. , Shushunova Natalia A. , Bratashov Daniil N. , Prikhozhdenko Ekaterina S. , Verkhovskii Roman A. , Kozlova Anastasiia A. , Abdurashitov Arkady S. , Sindeeva Olga A. , Karavaev Anatoly S. , Kulminskiy Danil D. , Shashkov Evgeny V. , Inozemtseva Olga A. , Tuchin Valery V. 
Published: July 2023

AbstractPhotoacoustic flow cytometry is one of the most effective approaches to detect “alien” objects in the bloodstream, including circulating tumor cells, blood clots, parasites, and emboli. However, the possibility of detecting high‐amplitude signals from these objects against the background of blood depends on the parameters of the laser pulse. So, the dependencies of photoacoustic signals amplitude and number on laser pulse energy (5–150 μJ), pulse length (1, 2, 5 ns), and pulse repetition rate (2, 5, 10 kHz) for the melanoma cells were investigated. First, the PA responses of a melanoma cell suspension in vitro were measured to directly assess the efficiency of converting laser light into an acoustic signal. After it, the same dependence with the developed murine model based on constant rate melanoma cell injection into the animal blood flow was tested. Both in vivo and in vitro experiments show that signal generation efficiency increases with laser pulse energy above 15 μJ. Shorter pulses, especially 1 ns, provide more efficient signal generation as well as higher pulse rates. A higher pulse rate also provides more efficient signal generation, but also leads to overheating of the skin. The results show the limits where the photoacoustic flow cytometry system can be effectively used for the detection of circulating tumor cells in undiluted blood both for in vitro experiments and for in vivo murine models.
Jumping spider invades an orb web to prey on a resident male
Authors: Kuntner Matjaž , Kuntner Eva , Kuntner Maj , Kuntner Irena , Li Daiqin 
Published: July 2023

AbstractWhile surveying operational sex ratios of the giant golden orb weaverNephila pilipes(Fabricius, 1793) in Singapore, we documented a stunning case of predatory behavior of a jumping spiderViciria pavesiiThorell, 1877. A femaleV. pavesiiinvaded aN. pilipesorb web that was occupied by the resident female and four males, and successfully captured, killed, and removed one of theNephilamales. Whether araneophagy inV. pavesiiis opportunistic or a predatory ritual remains to be tested more precisely, but because the observed predatory event triggered an aggressive response by theN. pilipesalpha male, it is plausible thatV. pavesiimay engage in aggressive mimicry. We place our observation into the context of jumping spider cognition and behavioral tactics that are so far well understood only in a few spartaeine genera, notablyPortiaKarsch, 1878.ViciriaThorell, 1877, we argue, is another such jumping spider taxon worthy of behavioral scrutiny.