bluuebunny/crossref_metadata_2025_split huggingface dataset:
An artificial intelligence method using 18F-FDG PET maximum intensity projections to predict 2-year time-to-progression in diffuse large B-cell lymphoma patients
Authors: Ferrández Maria C. , Golla Sandeep S. V. , Eertink Jakoba J. , de Vries Bart M. , Lugtenburg Pieternella. J. , Wiegers Sanne E. , Zwezerijnen Gerben J. C. , Pieplenbosch Simone , Kurch Lars , Hüttmann Andreas , Hanoun Christine , Dührsen Ulrich , de Vet Henrica C.W. , Zijlstra Josée M. , Boellaard Ronald 
Published: April 2023

Abstract
Convolutional neural networks (CNNs) may improve response prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to investigate the feasibility of a CNN using maximum intensity projection (MIP) images from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) baseline scans to predict the probability of time-to-progression (TTP) within 2 years and compare it with the International Prognostic Index (IPI), i.e. a clinically used score. 296 DLBCL 18F-FDG PET/CT baseline scans collected from a prospective clinical trial (HOVON-84) were analysed. Cross-validation was performed using coronal and sagittal MIPs. An external dataset (340 DLBCL patients) was used to validate the model. Association between the probabilities, metabolic tumour volume (MTV) and Dmaxbulk was assessed. Probabilities for PET scans with synthetically removed tumors were also assessed. The CNN provided a 2-year TTP prediction with area under the curve (AUC) of 0.74, outperforming the IPI-based model (AUC = 0.68). A moderate association of CNN probabilities with MTV (r = 0.57) and Dmaxbulk (r = 0.52) was observed in the external dataset. Furthermore, high probabilities (> 0.6) of the original MIPs were considerably decreased after removing the tumours (< 0.4, generally). These findings suggest that MIP-based CNNs are able to predict treatment outcome in DLBCL.
Hybrid Movement Training During the Pandemic: A Clash Between Physical and Digital Realm
Authors: Serdar Bilge 
Published: April 2023

AbstractThis ethnographic research was conducted in one of the physical training institutions that offer the Laban/Bartenieff Movement Studies (LBMS) certification program in Berlin in 2021. Because of the COVID-19 pandemic crisis, the training was held in a hybrid format in which some participants were in the studio, and others were attending remotely via Zoom. Zoom-mediated movement training for long hours revealed how the intervention of telematic technologies challenged practitioners’ sensorial experience and sense-making process. Moreover, bringing co-located and remote participants’ experiences together in the hybrid setting disclosed different modes of interaction dynamics in the studio and online. Overall, participants described their hybrid experience as a clash. In the article, starting from unfolding those clashes, I discuss ‘How does remote participation through telematics challenge participants’ sensorial experience?’, ‘What can and cannot be transmitted through online mediation?’ and ‘How does remote interaction through a telematic system (Zoom) affect the shared sense-making process in the hybrid format setting?’.
Event-related potentials of social comparisons in depression and social anxiety
Authors: Paz Valentina , Nicolaisen-Sobesky Eliana , Fernández-Theoduloz Gabriela , Pérez Alfonso , Cervantes-Constantino Francisco , Martinez-Montes Eduardo , Kessel Dominique , Cabana Alvaro , Gradin Victoria Beatriz 
Published: April 2023

Abstract
Social comparison is central in human life and can be especially challenging in depression and social anxiety. We assessed event-related potentials and emotions when receiving feedback on both their own and a co-player’s performance, in participants with depression and/or social anxiety (n=63) and healthy controls (n=72). Participants reported more negative emotions for downward (being better than someone else) and upward (being worse) comparisons vs. even outcomes, with these effects being stronger in depression and social anxiety. At the Medial Frontal Negativity, both controls and depressed participants showed enhanced negativity for upward (participant wrong, co-player correct) comparison vs. both the participant and co-player performing wrong. Socially anxious subjects showed the opposite effect, possibly due to greater expectations about being worse than others. The P300 decreased for downward and upward comparisons compared to even outcomes, which may relate to the higher levels of conflict of social inequality. Depressed and socially anxious subjects showed a blunted P300 increase over time in response to the task outcomes, suggesting deficits in allocating resources for the attention of incoming social information. This may relate to difficulties in these disorders in learning how to deal with the cognitive/emotional demands of social comparison.
Effect of Neighborhood Deprivation Index on Breast Cancer Survival in the United States
Authors: Roy Arya Mariam , George Anthony , Attwood Kristopher , Alaklabi Sabah , Patel Archit , Omilian Angela R , Yao Song , Gandhi Shipra 
Published: April 2023

Abstract
Purpose
To analyze the association between the Neighborhood Deprivation Index (NDI) and clinical outcomes of early-stage breast cancer (BC).
Methods
Surveillance, Epidemiology and End Results (SEER) database is queried to evaluate overall survival (OS) and disease-specific survival (DSS) of early- stage BC patients diagnosed between 2010–2016. Cox multivariate regression was performed to measure the association between NDI (Quintiles corresponding to most deprivation (Q1), above average deprivation (Q2), average deprivation (Q3), below average deprivation (Q4), least deprivation (Q5)) and OS/DSS.
Results
Of the 88,572 early-stage BC patients, 27.4% (n = 24,307) were in the Q1 quintile, 26.5% (n = 23,447) were in the Q3 quintile, 17% (n = 15,035) were in the Q2 quintile, 13.5% (n = 11,945) were in the Q4 quintile, and 15.6% (n = 13,838) were in the Q5 quintile. There was a predominance of racial minorities in the Q1 and Q2 quintiles with Black women being 13–15% and Hispanic women being 15% compared to only 8% Black women and 6% Hispanic women in the Q5 quintile (p < 0.001). In multivariate analysis, in the overall cohort, those who live in Q2 and Q1 quintile have inferior OS and DSS compared to those who live in Q5 quintile (OS:- Q2: Hazard Ratio (HR) 1.28, Q1: HR 1.2; DSS:- Q2: HR 1.33, Q1: HR 1.25, all p < 0.001).
Conclusion
Early-stage BC patients from areas with worse NDI have poor OS and DSS. Investments to improve the socioeconomic status of areas with high deprivation may help to reduce healthcare disparities and improve breast cancer outcomes.
Short-time prediction model for cross-section passenger flow of trains in urban transit using GCN-AM-BiLSTM
Authors: Zuo Jing , Yu Zhao , Liu Guo Yan , He Ming 
Published: April 2023

Abstract
With the proliferation of passenger flow under the condition of network condition, the imbalanced temporal and spatial distribution of passenger flow occurs frequently, which brings enormous challenges to the operation of urban rail systems. Effectively predicting the short-time passenger flow of trains is an important prerequisite to optimize the transportation strategies, respond to the fluctuation of passenger flow and meet the real-time demand. Consequently, the GCN-AM-BiLSTM prediction model is proposed to extract the complex temporal and spatial characteristics of passenger flow. Firstly, the urban rail transit temporal diagram and spatial adjacency matrix are constructed to capture the global spatial characteristics using GCN. Secondly, the attention mechanism is introduced into the BiLSTM to construct the AM-BiLSTM module to extract and assign the importance of temporal characteristics from both the forward and backward dimensions. Finally, the characteristics are integrated based on the fusion network. The performance verification and analysis based on Chengdu Metro in China show that compared with several baseline models, our model achieves the best values in terms of MAE, RMSE and MAPE. The prediction efficiency can fully meet the timeliness requirements of the field, which has good application prospects.
CCL5 and GLUT1 define leader cells in collective invasion of colorectal cancer
Authors: Wang Feifei , Zhang Zhaowen , Zeng Zhicheng , Zhu Xiaohui , Mai Liyao , Yin Yao , Zhang Ceng , Kang Wei , Wu Xiangkun , Jiang Honghui , Zeng Sisi , Xiao Jianbiao , Xu Shaowan , Ding Yanqing , Pan Xinghua , Liang Li 
Published: April 2023

Abstract
Background
Many solid tumors rely heavily on the regulation and organization of leader and follower cells during the collective invasion. However, leader cells’ specific biomarkers and mechanisms in colorectal cancer (CRC) collective invasion are unclear. This study aimed to identify the specific biomarkers of leader cells and reveals their molecular mechanisms during CRC collective invasion and metastasis.
Methods
The 3D photoconvertible CRC spheroid model in vitro was constructed to isolate leader cells and follower cells. The RNA-Seq, functional, and animal experiments revealed that GLUT1, PLOD2, and CCL5 in leader cells were required for CRC collective invasion.
Results
CCL5 up-regulated the expression of GLUT1 and PLOD2 through PI3K/Akt signaling in leader cells. Moreover, GLUT1 and CCL5 could be used as specific biomarkers for leader cells in CRC collective invasion, and their co-expression was associated with poor prognosis of CRC patients. Notably, blocking GLUT1 and CCL5-CCR5 effectively inhibited CRC collective invasion.
Conclusions
Our findings illustrate that CCL5 and GLUT1 may define leader cells and are required for CRC collective invasion as a potential key regulator of hypoxia-induced metabolic shifts and collagen deposition.
Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma
Authors: Riihimäki Miia , Fegraeus Kim , Nordlund Jessica , Waern Ida , Wernersson Sara , Akula Srinivas , Hellman Lars , Raine Amanda 
Published: April 2023

Abstract
Equine asthma (EA) is a heterogenous, complex disease, with a significant negative impact on horse welfare and performance. EA and human asthma have fundamental similarities, making EA a useful large animal disease model. Bronchoalveolar lavage fluid (BALF) provides a snapshot sample of the immune cells occupying the alveolar space and is one of the most relevant sample types for studies of chronic inflammation in the lung. In this study, we performed single cell RNA-seq analysis of equine BALF cells in order to study the immune cell landscape of the respiratory tract of horses diagnosed with mild-to-moderate EA (mEA) and healthy controls. We characterized the major immune cell populations in equine BALF, as well as subtypes thereof. Interestingly, the most significantly upregulated gene found in mEA was FKBP5, a chaperone protein involved in regulating the assembly, activity, and sensitivity of the glucocorticoid receptor.
Expression of the Ced-9 (Cell Death abnormal-9) gene in transgenic Chrysanthemum morifolium can enhance drought and salt tolerances
Authors: Ri Tong-Chol , Kim Myong-Son , Kim Yong-Ho , Ri Chol-Jun , Pak Ryong-Ho , Ri Jin-Hyang 
Published: April 2023

Abstract
Salt and drought are important abiotic stresses of Chrysanthemum morifolium(Asteraceae). Limited information is available with regard to molecular management strategies for salt and drought. Ced-9 (Cell Death abnormal-9) is already known to enhance the tolerance of plants to abiotic stresses. Asteraceae plants overexpressing Ced-9 have showed improved tolerance to stresses - they kept freshness for longer time, and were fast to grow, and had higher tolerance to salt. Additional analyses revealed that transgenic plants generally show lower transpiration rate and higher chlorophyll content when subjected to salt and drought stresses. These results suggest that Ced-9 inhibits the activity of a cysteine protease with caspase-like activity and that Ced-9 also enhances salt and drought tolerances by maintaining intracellular ion balance by apparently inhibiting the external efflux of K+ induced by salt stress. Ced-9 has been proved to improve the low temperature tolerance of asteraceae plants by controlling 2,4-D signal and other pathways responding to stresses.
Why Majority Judgement is not yet the solution for political elections, but can help finding it
Authors: Kemm Friedemann 
Published: April 2023

Abstract
Like many other voting systems, Majority Judgement suffers from the weaknesses of the underlying mathematical model: Elections as problem of choice or ranking. We show how the model can be enhanced to take into account the complete process starting from the whole set of persons having passive electoral rights and even the aspect of reelection. By a new view on abstentions from voting and an adaption of Majority Judgement with three grades, we are able to describe a complete process for an election that can be easily put into legislation and sets suitable incentives for politicians who want to be reelected.
JEL Classification: D72 , D71
MSC Classification: 91-10 , 91B12 , 91B14
On-demand quadruple energy dissipative strategy for the nanoengineering of versatile bio- adhesive-based “tissue-alarm” for integrated wound therapy
Authors: Yue Ouyang , Wang Xuechuan , Hou Mengdi , Sun Siwei , Zheng Manhui , Hao Dongyu , Bai Zhongxue , Zou Xiaoliang , Cui Boqiang , Liu Chunlin , Zhang Huijie , Liu Jialing , Guo Junling , Liu Xinhua 
Published: April 2023

Abstract
Wound abnormalities such as secondary wound laceration and inflammation are common postoperative health hazards during clinical procedures. Electroactive hydrogel adhesives with emerging bioelectronics have been showing great promise as next-generation intelligent biomaterials. However, these adhesives partially suffer from insufficient strength, limited application scenarios, monotonous functions, and difficulty in early warning of wound abnormalities. Herein, an on-demand quadruple energy dissipative strategy was proposed for the nanoengineering of a physically and chemically synergistic gelatin-based bio-adhesive (DLGel) as a "tissue-alarm" by combining a multi-network adhesive layer and a versatile electroactive energy dissipative layer based on contrivable interlocking micro-pillar arrays and crosslinked polymer chains. The subtly multiple energy dissipation designs enable DLGel with robust adhesive strength to omnipotently wet and dynamic tissue, providing a basis for reliable wound closure. Interestingly, DLGel could serve as a “tissue-alarm”, providing highly sensitive real-time early warning and suture assessment for postoperative wound abnormalities, such as laceration, inflammation, and necrosis.In vitro and in vivo experiments confirmed that DLGel could significantly promote wound recovery without the drug for full-thickness dermal defects. Meanwhile, DLGel prosperously exhibited integrated reversible underwater photo- and thermal adhesion, hemostatic properties, antimicrobial activity, and self-healing capability, and further enabling the integration of reliable wound closure, wound healing, and real-time wound abnormalities warning in the era of intelligent medicine.
Characterization and Antimicrobial Activity of PVA/ Chitosan/ Clay/ Essential Oil Hydrogel Prepared via Freeze-Thaw
Authors: Bayraktar Seyda , Copur Buse , Gunes Erdogan , Uysal Ahmet , Okudan Ahmet 
Published: April 2023

Abstract
In this study, eco-friendly, low-cost and high-antimicrobial activity Polyvinyl alcohol(PVA)/Chitosan (CHT)/Clay/Oil nanocomposite hydrogels were prepared via freeze-thaw (F-T) method. Montmorillonite (MMT) and nanoclay (NC) were added as clay to PVA/CHT/Clay/Oil hydrogels. MMT and NC decreased the number of F-T cycles in the hydrogel and increased the surface hydrophilicity of the hydrogels. Clove, aloe vera and argan oil were added as oil to PVA/CHT/CLAY mixtures. Hydrogels containing clove oil showed antimicrobial activity against eight microorganisms (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 70603, methicilline resistant Staphylococcus aureus ATCC 43300 (MRSA), Salmonella enteritidis ATTC 13076, Sarcina lutea ATCC 9341, Bacillus cereus ATTC 11778, Candida albicans NRRL Y-417). Nanocomposite hydrogels containing clove oil , have been found to have high antimicrobial activity, skin adhesion and swelling degree. Contact angle values less than 90° were measured PVA/CHT-4/MMT-4/ Oilclove2, PVA/CHT-4/NC- 4/Oilclove2 hydrogels. According to FT-IR, SEM, XRD, Contact angle, and swelling test results, PVA/CHT/Clay/Oil hydrogel content was determined as 25 µL of clove oil and 72.7% PVA (400 mg), 9.1% CHT (50 mg), 18.2% Clay (100 mg).
Overexpressing Plant Ferredoxin-like Protein Enhances Photosynthetic Efficiency andCarbohydrates Accumulation in Phalaenopsis
Authors: Chang Hsiang , Chen Yen-Ting , Huang Hsiang-En , Ger Mang-Jye 
Published: April 2023

Abstract
Crassulacean acid metabolism (CAM) is one of three major models of carbon dioxide assimilation pathway with better water-use efficiency and slower photosynthetic efficiency inphotosynthesis. Previous studies indicated that overexpressing the plant ferredoxin-like protein (PFLP) cloned from sweet pepper can enhance disease resistance to bacterial pathogens and boost photosynthesis rate in C3 and C4 plants, but not for CAM. The protein sequence of PFLP shows high homology to the ferredoxin-1(Fd-1) family that belongs to photosynthetic type Fd and involves in photosystem I. It is speculated that overexpressing pflp in the CAM plant may enhance photosynthetic efficiency through the electron transport chain (ETC). In this report, pflp transgenic Phalaenopsis were generated to reveal the effects of overexpressing PFLP in CAM photosynthetic efficiency with several photosynthetic features. For the electron transport rate (ETR), the transgenic pflp plants exhibited by 1.2-folds than those of wild type (WT).The efficiency of the photosynthetic electron transport chain (PETC) was 1.7-folds due to the quantum efficiency of linear electron flow (LEF) elevated in transgenic pflp plants. Higher CO2 assimilation rates were observed up to 1.6 and 1.5-folds sampled at 4 pm and10 pm respectively. In the Phase III of CAM, the enzyme activity of phosphoenolpyruvate carboxylase (PEPC) was increased by 5.9-folds, and in the Phase IV, NAD+-linked malic enzyme (NAD+-ME) activity was increased by 1.4-folds in transgenic pflp plants. For the evaluation of photosynthesis products, the carbohydrate levels were analyzed. Soluble sugars contents such as glucose, fructose, and sucrose were increased significantly by 1.2, 1.8, and 1.3-folds higher in transgenic pflp plants. The starch grains were also accumulated up to 1.4-folds. These results indicated that overexpressing pflp in transgenic CAM plants can increase carbohydrates accumulation by enhancing electron transport flow during photosynthesis. Taken altogether, we suggested that pflp is an potential gene for agriculture application that not only increases disease resistance but also enhances electron transport chain efficiency during photosynthesis.
Linear Programming with Non-Archimedean Right-Hand Sides
Authors: Cococcioni Marco , Fiaschi Lorenzo 
Published: April 2023

Abstract
The goal of this work is to propose a new type of constraint for linear programs: inequalities having a non-Archimedean right-hand side. Here, the word non-Archimedean refers to values that can be infinite, finite, or infinitesimal. Because of the nature of such constraints, the polyhedron describing the feasible region becomes more complex, since its vertices are now represented by non-Archimedean coordinates, and so is the optimum of the problem. The introduction of such a constraint enlarges the class of linear programs, where the Archimedean ones become a special case. To tackle optimization problems over the resulting polyhedra, this work presents a solving routine, which consists in a generalization of the Simplex algorithm. This solver optimizes Archimedean linear programs as corner cases. Finally, the study presents three relevant applications which can benefit from the use of constraints with non-Archimedean right-hand side, making the use of the extended Simplex algorithm essential. For each application, an exemplifying benchmark is solved, showing the effectiveness of the solving routine.
Modelling Pathways to Energy Transition in Pakistan using OSeMOSYS (Open-Source Energy Modelling System)
Authors: Nájera-Aguirre Aura , Rogelj Joeri , Yeganyan Rudolf , Cannone Carla , Tan Naomi , Howells Mark 
Published: April 2023

Abstract
In the past two decades, fast growing population and energy demand has prompted the Government of Pakistan (GoP) to maintain investment in imported fossil fuels. For a developing country under a large circular debt, this has inhibit Pakistan to bridge the energy demand-supply gap. Recent social mobilisations and awareness on the degradation of national environment has forced GoP to consider and promote the deployment of new and renewable energy technologies for power generation. In 2019, the Alternative and Renewable Energy policy represented a turning point in national energy planning. Energy modelling has become an increasingly important tool for country intending to meet their NDC targets. By utilising OSeMOSYS, this study explores most cost-effective pathway towards energy transition and security in the short-, medium-, and long-term. Three scenario are drawn from this study: Least Cost (LC), Fossil Future (FF), and Net-Zero (NZ). Results provides key insights on installed capacity and production, as well as emissions, costs and investment for each modelled scenario. Thus, under a comprehensive overview of Pakistan energy system, variable renewable energies (VRE) are seen to have the highest potential to support energy transition while feeding national demand. It is later discuss ways to implement VRE to further sustainable energy transition in Pakistan. This include the impact of such technologies in energy security, most cost-effective options, and co-benefits, without excluding existing challenges. Recommendations for planning a renewable future in Pakistan focus on further assessment of energy demand and economic growth, improving efficiency, generating investment, and coal- phaseout. Whilst this study was successful under determined framework, some limitations invite further research to be conducted.
The Necessity of Ureteral Access Sheath for Flexible Ureteroscopy in Large Renal Stones Treatment
Authors: Elbakary Mohamed 
Published: April 2023

Abstract
-Introduction: ureteral access sheath (UAS) has been used in flexible ureteroscopy (FURS) without clear guidelines for its usage. UAS allows multiple entries and extractions of the fragments during flexible ureteroscopy. -Objectives: evaluate the need for UAS in FURS and if it is possible to do FURS without UAS with large renal stones. -Methodology: during the last 5 years, 166 patients has done FURS with laser fragmentation of large renal stones > 2cm. These patients had been divided into two groups according to UAS usage or not. Preoperative, operative and postoperative data were collected. Success rate and complications had been collected and analyzed. -Results: In 166 patients, UAS was used in 90(54.2%) cases, and UAS was not used in 76(45.8%) cases. The mean stone's largest diameter was 26.2 ± 3.8 mm in using UAS, while the mean stone's largest diameter was 25.8 ± 4.9 mm in not using UAS (P = 0.647). The mean stone density was 1073.3 ± 237.7 HU in using UAS, while the mean stone density was 922.1 ± 293.3 HU in not using UAS (p = 0.011*). The mean operative time was 106.2 ± 27.9 min in using UAS, while the mean operative time was 89 ± 26.3 min in not using UAS (P = 0.005*). The (SFR) was 87% for using UAS and 89% for not using UAS (P = 0.700). The complications were detected in 12(7.2%) patients using UAS and 22(13.3%) patients not using UAS. -Conclusion: Flexible ureteroscopy without ureteral access sheath is safe and efficient even with larger renal stones with acceptable more complications.