bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repolarization of inflammation-associated macrophages by multifunctional dual drug-loaded liposome with antibacterial capacity for acute lung sepsis synergistic therapy
Authors: Zhang Qing , Zhang Lin , Zhang Yuhan , Wang Yi , Ju Rong , Wei Guoqing 
Published: February 2023

Abstract
Background Sepsis is defined a systemic inflammatory response syndrome caused by a dysregulated host response to bacterial infection and is the leading cause of death in the intensive care unit at hospitals. At present, despite the discovery of many potential therapeutic methods for anti-infective treatment and immune-suppressing treatment, effective drug treatments for sepsis are lacking in the clinic.
Results Herein, a novel coloaded dual therapeutic agent liposomes (Cip·HCl/Cur@Lip-γ3) nanoplatform was developed by enveloping Cip·HCl and Cur into pH-responsive and inflammation-targeted liposomes. These liposomes simultaneously kill bacteria and regulate the polarization type of macrophages in infected lung tissue to relieve the infected microenvironment, providing antibacterial-anti-inflammatory therapy for synergetic acute lung sepsis antibacterial-anti-inflammatory therapy. In vitro and in vivo results showed that Cip·HCl/Cur@Lip-γ3 exhibits excellent antibacterial properties against both S. aureus and P. aeruginosa and can effectively reduce inflammation and the immune response in acute lung infection. In addition, Cip·HCl/Cur@Lip-γ3 was administered to mice with acute lung infection, and the survival rate was 80% within 72 h.
Conclusion This study provides a novel nanoplatform to treat lung infection-induced sepsis, providing a new strategy to design multifunctional nanomedicine for infectious disease therapy.
WITHDRAWN: Neurological manifestations of Multisystem Inflammatory Syndrome in children (MIS-C) associated with SARS-CoV-2 infection: A clinico-demographic profile with short-term outcome in patients admitted to a tertiary care hospital in Eastern India.
Authors: Roy Santanu , Ghosh Prakash Chandra , Biswas Sandip , Majumder Sananda 
Published: February 2023

Abstract
Background: In April 2020, a novel syndrome termed multisystem inflammatory syndrome in children (MIS-C), related to SARS-CoV-2 infection was first described. This syndrome has a wide spectrum of systemic involvement, has shown to include the nervous system as well. Our study aims to obtain a baseline clinical and demographic profile of varied neurological manifestations of MIS-C. It also aims to delineate a profile of short-term outcome in these patients with regards to residual neurological sequelae.
Methods: A single-centre, retrospective, observational and hospital based study for 5 months was conducted among patients in the age group from 1 month to 12 years, with MIS-C with co-existing neurological symptoms. The subjects who had pre-existing neurological diseases were excluded from the study. A total of 34 subjects were collected. Post-discharge, each patient was followed up for a period of 1 month. The residual neurological deficits, if any, at discharge and follow-up.
Results: The neurological complication found were Acute Symptomatic Seizure (29.4%), Aseptic Meningitis (23.5%), Encephalitis (11.8%), Guillain-Barré Syndrome (11.8%), Miller-Fisher Syndrome (2.9%), ADEM (8.8%), Autoimmune Encephalitis (8.8%) and Acute Haemorrhaegic Stroke (2.9%). 11.8% expired and 50% required P.I.C.U admissions. 23.5% had residual neurological deficit at discharge and 8.8% at follow-up after 1 month of discharge.
Conclusions: In spite of great variability in manifestations, prognosis is favourable if early aggressive treatment is initiated.
Investigation of the adsorption mechanism of formaldehyde on pure and Pt- doped rutile SnO2 (110) surfaces: a theoretical analysis via first principles study
Authors: Gulshanah Shaheen , Bhattacharjee Ayon 
Published: February 2023

Abstract
This work presents an extensive study for analysing the adsorption mechanism of formaldehyde on pure and Pt-doped rutile SnO2 (110) surfaces via Density Functional Theory (DFT) method. Out of the two suitable surface sites for Pt-doping, namely, Sn5c and Sn6c, the latter was found to be more suitable for Pt-doping. Three formaldehyde configurations were considered, η1(O)-straight, η1(O)-tilted and η2(O,C)-tilted. It was found that after Pt-substitution, the adsorption energies for η1(O)-tilted and η2(O,C)-tilted formaldehyde geometries were improved. This improvement could be due to strengthened interaction between formaldehyde and Sn5c sites after doping, and also due to the surface coverage induced by the tilt angle of the gas molecule w.r.t the surface. Also, the overall adsorption energy values were better for the tilted configurations rather than the straight geometry. Bader charge analysis results show the presence of both chemisorption as well as physisorption for tilted formaldehyde geometry, whereas only chemisorption has been observed in case of straight orientation. Charge density difference (CDD) plots visually verified the above stated results. Total density of states show the injection of additional electronic states near zero energy (Fermi energy) level after Pt-doping and an additional peak upon introduction of the gas molecule.
Complications and Hospitalization Costs in Patients with Hypothyroidism Following Total Hip Arthroplasty：A Retrospective InpNationwide atient Sample Database Study
Authors: Yang Qinfeng , Huang Yuzhi , Chen Yuhang , Li Kunlian , Gan Wei , Shi Zhanjun , Wang Jian 
Published: February 2023

Abstract
Introduction: Hypothyroidism is a common disease in the US population. The impact of hypothyroidism on perioperative complications of total hip arthroplasty is poorly understood. To examine risk factors and hospitalization costs in patients with hypothyroidism after total hip arthroplasty (THA) using a large-scale sample national database. Methods: A case-control study was performed based on the National Inpatient Sample (NIS) database from 2005 to 2014. With the use of propensity scores, patients with hypothyroidism were matched in a 1:1 ratio to those without hypothyroidism by age, gender, race, Elixhauser Comorbidity Index (ECI), and insurance type. Patient demographics, postoperative complications, length of stay (LOS), and hospital costs were compared between matched cohorts. Short-term complication rates after THA were compared using multivariate logistic analysis. Results: The proportion of patients with hypothyroidism receiving THA was 12.97%. Linear regression analysis yielded that patients with hypothyroidism receiving THA were more likely to have postoperative acute anemia (odds ratio = 1.15; 95% confidence interval = 1.12–1.18) and higher mean hospital costs compared to the non-hypothyroid cohort. Conclusions: This present study demonstrates that hypothyroid patients undergoing THA have a higher risk of short-term complications. Furthermore, it significantly increased the total cost of hospitalization, which deserves more attention from orthopedic surgeons.
Hospitalization Rates Following mRNA SARS-CoV-2 Booster Vaccination among Patients with and without Prior SARS-CoV-2 Infection: A Nationwide, Retrospective Cohort Study
Authors: Zheng Chunlei , Branch-Elliman Westyn , Fillmore Nathanael R , Monach Paul A 
Published: February 2023

Abstract
Background
We previously reported a transient increased risk of hospitalization after mRNA vaccination among patients with prior SARS-CoV-2, absolute risk ~ 1:1000. Here, we extend and expand this analysis to evaluate the impact of prior infection on hospitalization after a third (booster) dose.
Methods
Nationwide, retrospective cohort study of hospitalization among US Veterans who received a third dose of mRNA vaccine between 7/1/2021-2/28/2022. Daily rates of incident hospitalization were compared before and after booster doses, stratified by history of SARS-CoV-2.
Results
1,632,806 patients received a third dose, including 90,174 with a history of SARS-CoV-2 infection. Hospitalization rates were unchanged before and after the booster dose among patients with (112.3/100,000 post-dose versus 100.2/100,000 pre-dose, p = 0.24) or without previous infection (32.1/100,000 post-dose versus 31.3/100,000 pre-dose, p = 0.71). Among 241 patients hospitalized after receipt of the initial vaccination, 90 received a booster, and none of these 90 patients were hospitalized.
Conclusions
There was not convincing evidence for increased hospitalizations shortly after booster vaccines, including in patients with a history of SARS-CoV-2 infection who required hospitalization after their initial vaccine. The size and design of the study prevent strong conclusions about absence of risk.
Ab initio Quantum Simulation of Strongly Correlated Materials with Quantum Embedding
Authors: Dingshun Lv , Cao Changsu , Sun Jinzhao , Yuan Xiao , Hu Han-Shi , Pham Hung Q. 
Published: February 2023

Abstract
Quantum computing has shown great potential in various quantum chemical applications such as drug discovery, material design, and catalyst optimization. Although significant progress has been made in quantum simulation of simple molecules, ab initio simulation of solid-state materials on quantum computers is still in its early stage, mostly owing to the fact that the system size quickly becomes prohibitively large when approaching the thermodynamic limit. In this work, we introduce an orbital-based multi-fragment approach on top of the periodic density matrix embedding theory, resulting in a significantly smaller problem size for the current near-term quantum computer. We demonstrate the accuracy and efficiency of our method compared with the conventional methodologies and experiments on solid-state systems with complex electronic structures. These include spin polarized states of a hydrogen chain (1D-H), the equation of state of a boron nitride layer (h-BN) as well as the magnetic ordering in nickel oxide (NiO), a prototypical strongly correlated solid. Our results suggest that quantum embedding combined with a chemically intuitive fragmentation can greatly advance quantum simulation of realistic materials, thereby paving the way for solving important yet classically hard industrial problems on near-term quantum devices.
Między przebojowością a wycofaniem. Czy współczesny świat jest zbyt nieprzyjazny dla ludzi nieśmiałych?
Authors: Pospiszyl Irena 
Published: February 2023

Wielu badaczy wskazuje na pewien paradoks dotyczący wymagań wobec współczesnego człowieka. Z jednej strony oczekujemy żeby był on asertywny, samodzielny, społecznie kompetentny i łatwo przystosowujący się do nowych sytuacji. W takich warunkach podstawowym mechanizmem radzenia sobie w świecie społecznym jest jego własna atrakcyjność, umiejętność zaciekawienia sobą, odnalezienia tego, co wspólne, współbrzmienia z innymi. Z drugiej zaś strony, współczesny świat ze swoim galopującym tempem życia, zmiennością warunków i koniecznością nadążania za pojawiającymi się wyzwaniami powoduje u ludzi wzrost poczucia zagubienia, skłonności do wycofywania się i stanowi niezwykłe wyzwanie dla osób nieśmiałych.
Artykuł traktuje o problemach jednostek nieśmiałych w tym wymagającym współczesnym świecie oraz ukazuje sprzeczność pomiędzy oczekiwaniami a stwarzanymi warunkami do ich realizacji.
The experience of conflicts (internal and external) and the sense of meaning in life. An existential approach
Authors: Rumianowska Agnieszka 
Published: February 2023

Although there is a relatively long tradition of research into the mechanisms underlying conflicts (both internal and interpersonal ones), the existential perspective of conflict has not as yet been the subject of extensive psychological studies. From the standpoint of existential psychology, conflict is primarily an expression of an individual’s confrontation with objective existential facts: freedom and the responsibility for oneself that freedom entails, the finitude of human life, existential loneliness and fate in its broadest sense. Although conflict, so defined, is essentially an immanent feature of human existence, it becomes a problem when a strong sense of helplessness and anxiety starts to accompany it, as a person loses their purpose in life and fails to realize their personal values.
This research aimed to answer the question of whether there is a relationship between an individual’s behavior in response to (internal and interpersonal) conflict and his/her sense of meaning in life and preferred values. The study covered a group of 153 students aged from 19 to 26 years. Purpose-of-life was measured using the test developed by Crumbaugh and Maholick (1964). The Schwartz Portrait Values questionnaire was used to assess the respondents’ preferences for fundamental values. The behavior of the subjects in response to conflict was examined using linguistic (frequency) analysis of the verbs used in their open-ended answers.
In Vitro Effects of Bisphenol Analogs on Immune Cells Activation and Th
Differentiation
Authors: Pahović Pia Štrukelj , Iulini Martina , Maddalon Ambra , Galbiati Valentina , Buoso Erica , Dolenc Marija Sollner , Corsini Emanuela 
Published: February 2023

Aims:
Investigate the immunomodulatory effects of bisphenols in the THP-1 cell line
and peripheral blood mononuclear cells in response to lipopolysaccharide (LPS) activation or to
phorbol 12-myristate 13-acetate (PMA) and ionomycin.

Background:
We have previously demonstrated the usefulness of the evaluation of RACK1 expression
as a link between endocrine disrupting activity and the immunotoxic effect of xenobiotics. We
demonstrated that while BPA and BPAF reduced RACK1 expression, BPS was able to increase it.

Objective:
Bisphenol A (BPA) is one of the most commonly used chemicals in the manufacturing
of polycarbonate plastics and plastic consumer products. Its endocrine disrupting (ED) potential and
changes in European regulations have led to replacing BPA in many uses with structurally similar
chemicals, like bisphenol AF (BPAF) and bisphenol S (BPS). However, emerging data indicated
that bisphenol analogues may not be safer than BPA both in toxic effects and ED potential.

Methods:
THP-1 cell line and peripheral blood mononuclear cells were activated with lipopolysaccharide
(LPS) or with phorbol 12-myristate 13-acetate (PMA) and ionomycin.

Results:
BPA and BPAF decreased LPS-induced expression of surface markers and the release of
pro-inflammatory cytokines, while BPS increased LPS-induced expression of CD86 and cytokines.
BPA, BPAF, and BPS affected PMA/ionomycin-induced T helper differentiation and cytokine release
with gender-related alterations in some parameters investigated.

Conclusion:
Data confirm that bisphenols can modulate immune cell differentiation and activation,
further supporting their immunotoxic effects.
Vitamin D and COVID-19 Infection
Authors: Richter Josef , Vetvicka Vaclav , Král Vlastimil , Richterová Stanislava 
Published: February 2023

Objective:
The COVID-19 epidemic resulted in a global crisis of public health. Therefore, the possibility of prevention, leading to reduced infection and/or an improved disease state, is the subject of intensive attention. The novelty of this study is the direct evaluation of vitamin D levels with the risk of COVID-19 infection.

Background:
Currently, several nutraceuticals, including vitamin D, beta-glucan, and some minerals, are being studied for their role in stimulating immunity. Our study focused on the relationship between levels of vitamin D in immunodeficient patients and the risk of the development of COVID-19.

Method:
In this study, patients were supplemented with vitamin D.

Results:
In a group of 71 patients, we found that patients with vitamin D levels below 30 ng/ml had an increased risk of COVID-19 development and more severe disease progress. In patients with blood levels over 40 ng/ml, we consistently found high levels of protection against COVID-19 infection.

Conclusion:
The most important finding is that vitamin D levels above 40 ng/ml result in the reduction of risks of serious clinical manifestation of COVID-19 infection.
Mental Health Status and its Determinants among Higher Socio-Economic Married Working Women in Bangladesh
Authors: Haque Md. Imdadul , Akter Tasnim , Muhammad Faisal , Harun Md. Golam Dostogir , Hasan Md. Zobaer , ABM Alauddin Chowdhury 
Published: February 2023

Background:
Mental health is one of the most critical public health issues as it significantly contributes to the global disease burden worldwide.

Objective:
This study aims to assess the mental health status and its determinants among higher socio-economic married working women in Bangladesh.

Methods:
A cross-sectional study was conducted among 560 higher socio-economic married working women in different organizations in Dhaka City from June to November 2019. A semi-structured questionnaire was used to collect the information, and the mental health status was measured using CES-D Scale.

Results:
The odds of poor mental health were eleven times higher in participants that were always overloaded with work [AOR=10.9], more than nine times more likely among those that always had family members expecting the same work as non-working women [AOR=9.4], and eight times more likely in participants that had a lot of challenges from family/relatives/neighbors for pursuing job [AOR=8.2].

Conclusion:
Unfavorable working conditions, work overload,inadequate support from the organization and family have all been linked together to result in poor mental health. Significant efforts and resources are required to conduct both preventative and control programs.
WITHDRAWN: Research on Voltage Regulation Method and Strategy of DC Transmission Line
Authors: Wenjun Bao , Yi Yuan , Xiwen Ding , Shijie Bao 
Published: February 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

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Characterisation of Neonicotinoid Insecticides in the Cocoa-producing Owena River Basin of Nigeria by a QuEChERS Method Coupled to Liquid Chromatography-Tandem Mass Spectrometry
Authors: Cheung Philip C.W. , Busquets Rosa , Hooda Peter S. , Aseperi Adeniyi K. , Barker James , Adegun Ayodeji O. , Akinnifesi Thompson A. , Ololade Isaac , Abosede Sinmi 
Published: February 2023

Background:
Neonicotinoids (hereafter called “neonics”) are systemic insecticides used for the protection of agricultural crops. However, their dispersion in nature has been the subject of global concern due to reports of adverse effects on some living organisms. One of the applications of neonics in Nigeria is to protect the cocoa cash crop.

Objective:
Previous studies on pesticide-related pollution in Nigeria focused mainly on organochlorines, but research on neonics is sparse, and the knowledge gap needs to be filled. This work aimed at confirming the presence of four neonics, namely, imidacloprid, thiacloprid, acetamiprid, and thiamethoxam, within the Owena River Basin.

Methods:
Neonics were extracted from cocoa-growing soil, river water, and sediments by a modified QuEChERS method, followed by clean-up of the extractant by dispersive solid phase extraction and analysis by an optimized liquid chromatography/tandem mass spectrometry analytical procedure. The overall performance of these developed methods was then evaluated by set criteria.

Results:
The Limit of Detection (LOD) and Limit of Quantitation (LOQ) ranged from 0.0005 to 0.002 μg/g and 0.002 to 0.005 μg/g, respectively. The recovery for the four target analytes exceeded 75% across all matrices from laboratory-prepared samples. It was discovered that the average concentrations of three of the four neonics of interest in the individual media were: 10.34 nmol/g in cocoa-producing soil, 1.03 nmol/g in river sediment, and 1.08 nM (1.08 x 10-3 nmol/g) in surface river water. No imidacloprid was identified in any of these three environmental compartments.

Conclusion:
The concentration of neonics in the river water, i.e., 0.23 µg/L (230 ng/L), is identical to that of the maximum value recommended in the Canadian Water Quality Guidelines for the Protection of Freshwater Aquatic Life.
Jordan’s Population-Based Food Consumption Survey: Protocol for Design and Development
Authors: Al-Shami Islam , Al Hourani Huda , Alkhatib Buthaina , Alboqai Omar , AlHalaika Dima , Al-Jawaldeh Ayoub 
Published: February 2023

Background
One of the factors influencing health and well-being is dietary patterns. Data on food consumption are necessary for evaluating and developing community nutrition policies. Few studies on Jordanians’ food consumption and dietary habits at various ages have been conducted, despite the increased prevalence of overweight, obesity, and chronic diseases. This will be the first study focusing on Jordanians’ food consumption patterns that includes children, adolescents, adults, and older adults.

Objective
This cross-sectional study aims to describe the design and methodology of the Jordan’s Population-based Food Consumption Survey, 2021-2022, which was developed to collect data on food consumption, including energy, nutrients, and food group intake, from a representative sample of Jordanians and to determine the prevalence of overweight and obesity and their relationship to food consumption.

Methods
Participants were selected by stratified random sampling, using the Estimated Population of the Kingdom by Governorate, Locality, Sex, and Households, 2020 as the sampling frame. The food consumption survey sample was at the population level, representing gender and age classes (8-85 years old). The data collection period was 6 months. Food consumption was assessed using 24-hour dietary recall (2 nonconsecutive days, 1 week apart) interviews representing weekdays and weekends. In addition to data on food consumption, information on the use of food supplements, sociodemographic and socioeconomic status, and health was gathered. Weight, height, and waist circumference were all measured.

Results
The survey included 632 households with 2145 participants, of which 243 (11.3%) were children, 374 (17.4%) were adolescents, 1428 (66.6%) were adults, and 99 (4.6%) were older adults. Three food consumption databases were used to stratify the mean 24-hour dietary recall food consumption into energy intake, carbohydrates, proteins, fats, fiber, vitamins and minerals, and food groups. BMI was calculated and classified as normal, overweight, or obese. Central obesity was classified as normal or abnormal based on the waist-to-height ratio. The survey results will be disseminated based on age, energy, nutrient, and food group consumption. The prevalence of overweight and obesity by age group will be presented, as well as a comparison to the situation in Eastern Mediterranean countries.

Conclusions
The survey data will be helpful in nutritional studies, assessing changes in dietary patterns, and developing and evaluating nutrition or health policies. It will be a solid base for developing a future national surveillance system on food consumption patterns with comprehensive food consumption, physical activity, biochemical, and blood pressure data.

International Registered Report Identifier (IRRID)
DERR1-10.2196/41636