bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatiotemporal Theranostic Nanoprobes Dynamically Monitor Targeted Tumor Therapy
Authors: Fang Wei , Song Bangyu , Han Luyao , Tao Jinjin , Li Yiwen , Tang Rupei , Yan Guoqing 
Published: July 2023

AbstractCurrently, spatiotemporal theranostic nanoprobes are in great demand, owing to their enhanced target therapy and precise dynamic tracing of in vivo drug fate. Herein, this study highlights the successful development of dynamic theranostic nanoprobes, which are facilely established via self‐assembly between glutathione (GSH)‐responsive dasatinib (DAS) dimers and indocyanine green (ICG). The DAS dimers endow the nanoprobes with aggregation‐induced emission (AIE) characteristic, whose emission wavelength successfully redshifts from 420 to 810 nm compared to DAS‐based nanoprobes, the same as that of ICG, thus improving the total fluorescence intensity. Moreover, the nanoprobes exhibit a dynamic fluorescence intensity conversion that first decreases and then increases at the tumor site via intracellular GSH‐triggered AIE quenching and fluorescence re‐enhancement of ICG, therefore achieving precise tumor diagnosis, prognosis evaluation, and spatiotemporal tracing of drug fate compared to other imaging strategies. Furthermore, the nanoprobes show long‐term circulation stability via suitable particle sizes and zeta potentials, improved tumor accumulation via extracellular protonation and active cellular uptake, efficient drug release via response to the intracellular milieu, and enhanced apoptosis via targeting to intracellular kinase, therefore achieving the significant tumor inhibition. Thus, the spatiotemporal theranostic nanoprobes can dynamically monitor the targeted tumor therapy, greatly advancing their application in clinics.
Hierarchically Porous Implants Orchestrating a Physiological Viscoelastic and Piezoelectric Microenvironment for Bone Regeneration
Authors: Zhang Zheng‐Min , Yu Peng , Zhou Kai , Yu Fan‐Yuan , Bao Rui‐Ying , Yang Ming‐Bo , Qian Zhi‐Yong , Yang Wei 
Published: July 2023

AbstractThe extracellular matrix microenvironment of bone tissue comprises several physiological cues. Thus, artificial bone substitute materials with a single cue are insufficient to meet the demands for bone defect repair. Regeneration of critical‐size bone defects remains challenging in orthopedic surgery. Intrinsic viscoelastic and piezoelectric cues from collagen fibers play crucial roles in accelerating bone regeneration, but scaffolds or implants providing integrated cues have seldom been reported. In this study, it is aimed to design and prepare hierarchically porous poly(methylmethacrylate)/polyethyleneimine/poly(vinylidenefluoride) composite implants presenting a similar viscoelastic and piezoelectric microenvironment to bone tissue via anti‐solvent vapor‐induced phase separation. The viscoelastic and piezoelectric cues of the composite implants for human bone marrow mesenchymal stem cell line stimulate and activate Piezo1 proteins associated with mechanotransduction signaling pathways. Cortical and spongy bone exhibit excellent regeneration and integration in models of critical‐size bone defects on the knee joint and femur in vivo. This study demonstrates that implants with integrated physiological cues are promising artificial bone substitute materials for regenerating critical‐size bone defects.
Two‐Photon Light Trigger siRNA Transfection of Cancer Cells Using Non‐Toxic Porous Silicon Nanoparticles
Authors: Chaix Arnaud , Cueto‐Diaz Eduardo , Dominguez‐Gil Sofia , Spiteri Chantelle , Lichon Laure , Maynadier Marie , Dumail Xavier , Aggad Dina , Delalande Anthony , Bessière Aurélie , Pichon Chantal , Chiappini Ciro , Sailor Michael J. , Bettache Nadir , Gary‐Bobo Magali , Durand Jean‐Olivier , Nguyen Christophe , Cunin Frédérique 
Published: July 2023

AbstractThe concept of using two‐photon excitation in the NIR for the spatiotemporal control of biological processes holds great promise. However, its use for the delivery of nucleic acids has been very scarcely described and the reported procedures are not optimal as they often involve potentially toxic materials and irradiation conditions. This work prepares a simple system made of biocompatible porous silicon nanoparticles (pSiNP) for the safe siRNA photocontrolled delivery and gene silencing in cells upon two‐photon excitation. PSiNP are linked to an azobenzene moiety, which possesses a lysine group (pSiNP@ICPES‐azo@Lys) to efficiently complex siRNA. Non‐linear excitation of the two‐photon absorber system (pSiNP) followed by intermolecular energy transfer (FRET) to trans azobenzene moiety, result in the photoisomerization of the azobenzene from trans to cis and in the destabilization of the azobenzene‐siRNA complex, thus inducing the delivery of the cargo siRNA to the cytoplasm of cells. Efficient silencing in MCF‐7 expressing stable firefly luciferase with siRNAluc against luciferase is observed. Furthermore, siRNA against inhibitory apoptotic protein (IAP) leads to over 70% of MCF‐7 cancer cell death. The developed technique using two‐photon light allows a unique high spatiotemporally controlled and safe siRNA delivery in cells in few seconds of irradiation.
Unraveling the Coupling Effect between Cathode and Anode toward Practical Lithium–Sulfur Batteries
Authors: Gao Runhua , Zhang Mengtian , Han Zhiyuan , Xiao Xiao , Wu Xinru , Piao Zhihong , Lao Zhoujie , Nie Lu , Wang Shaogang , Zhou Guangmin 
Published: July 2023

AbstractThe localized reaction heterogeneity of the sulfur cathode and the uneven Li deposition on the Li anode are intractable issues for lithium–sulfur (Li–S) batteries under practical operation. Despite impressive progress in separately optimizing the sulfur cathode or Li anode, a comprehensive understanding of the highly coupled relationship between the cathode and anode is still lacking. In this work, inspired by the Butler–Volmer equation, a binary descriptor (IBD) assisting the rational structural design of sulfur cathode by simultaneously considering the mass‐transport index (Imass) and the charge‐transfer index (Icharge) is identified, and subsequently the relationship between IBD and the morphological evolution of Li anode is established. Guided by the IBD, a scalable electrode providing interpenetrated flow channels for efficient mass/charge transfer, full utilization of active sulfur, and mechanically elastic support for aggressive electrochemical reactions under practical conditions is reported. These characteristics induce a homogenous distribution of local current densities and reduced reaction heterogeneity on both sides of the cathode and anode. Impressive energy density of 318 Wh kg−1 and 473 Wh L−1 in an Ah‐level pouch cell can be achieved by the design concept. This work offers a promising paradigm for unlocking the interaction between cathode and anode and designing high‐energy practical Li–S batteries.
Dynamic Assembly‐Induced Time‐Resolved Optical Switches for Rewritable Advanced Information Encryption
Authors: Ai Yeye , Fei Yuexuan , Shu Zhu , Zeng Qingguo , Zhang Yinghao , Zhu Yihang , Lei Xin , Xu Jiayun , Liu Junqiu , Li Yongguang 
Published: July 2023

AbstractThe development of photocontrolled assembly of smart materials with time‐dependent optical characteristics is a promising strategy to fabricate multiple optical materials for advanced information encryption. Herein, this work reports the integration of photochoromic spiropyran and square‐planar platinum(II) as a photocontrolled switching motif that endows the materials with dynamic assembly‐induced optical characteristics. Importantly, the time‐resolved multilevel optical switching processes have been achieved based on the synergism of the reversible photochoromism and fluorescence resonance energy transfer (FRET) processes through regulating the intramolecular isomerization and intermolecular self‐assembly processes. The excellent temporal multicolor features promote the photocontrolled switches as a promising candidate for time‐resolved confidential materials including multilevel displays and dynamic 4 dimension (4D) codes, with the achievement of relative encrypted data that can only be identified at a specified time. This synergistical strategy for constructing advanced materials provides an inspiring guidance for information encryption with higher security requirements.
High‐Efficiency Structural Coloration Enabled by Defect‐Free Block Copolymer Self‐Assembly for a Solar Cell Distributed Bragg Reflector
Authors: Park Suhyeon , Shafian Shafidah , Lee Juhwan , Jo Seungyun , Jeon Seungbae , Lee Seungjae , Shangxian Ding , Ahn Hyungju , Kim Kyungkon , Ryu Du Yeol 
Published: July 2023

AbstractSolar cell coloration with minimum optical loss is increasingly required for building‐integrated photovoltaics (BIPV) in modern urban areas because of its importance in harmonizing the exterior of zero‐energy buildings and surroundings. A simple strategy for developing a distributed Bragg reflector (DBR) is designated with 1D lamella‐forming polystyrene‐b‐poly(2‐vinylpyridine) (PS‐b‐P2VP) films. An optimized thermal annealing process produces defect‐free lamellar microdomains oriented parallel to the substrate throughout the film. The selective crosslinking in the P2VP block and swelling of these films in a methanol solution with methanesulfonic acid facilitate the formation of highly asymmetric gigantic lamellae, enabling the entire visible‐wavelength spectrum of DBR structural colors. Three representative red (R), green (G), and blue (B) DBR films are produced on a Si solar cell. Coloration from high‐reflectance and narrow‐width DBR films results in vividly colored Si solar cells with a minor or negligible reduction in power conversion efficiency. The approach for photovoltaics, in terms of both the attractive esthetic and technical aspects of BIPV application, offers a viable method for fabricating high‐performance DBR films based on block copolymer self‐assembly.
Association between the antiadhesion membrane and small bowel obstruction after open gastrectomy: A supplemental analysis of the randomized controlled JCOG1001 trial
Authors: Toriumi Tetsuro , Terashima Masanori , Mizusawa Junki , Uemura Kohei , Kurokawa Yukinori , Takiguchi Shuji , Doki Yuichiro , Hihara Jun , Imamura Hiroshi , Takagane Akinori , Ito Seiji , Yoshikawa Takaki , Sano Takeshi , Sasako Mitsuru 
Published: July 2023

AbstractAimPostoperative small bowel obstruction (SBO) is one of the major complications that is mainly caused by postoperative adhesion. Recently, the antiadhesion membrane has become popular for postoperative SBO prevention. However, its efficacy is yet to be confirmed in the gastric cancer surgery field. Here, we conducted the supplemental analysis of the randomized controlled trial JCOG1001 to investigate the efficacy of the antiadhesion membrane on SBO prevention in patients with open gastrectomy for gastric cancer.MethodsOf the 1204 patients enrolled in JCOG1001, 1200 patients were included. The development of SBO of Grade ≥ IIIa according to the Clavien–Dindo classification was recorded. Univariable and multivariable analyses were performed using the Fine and Gray model to determine the risk factors for SBO.ResultsFifty‐one patients developed SBO (median follow‐up duration: 5.6 years). Total gastrectomy, combined resection, and blood loss significantly increased the risk for SBO development in the univariable analysis. Large amount of blood loss was independently associated with SBO development in the multivariable analysis (hazard ratio [HR], 3.089; 95% confidence interval [CI], 1.562–6.109, p = 0.0012). Antiadhesion membrane did not reduce the risk for SBO (HR, 1.299; 95% CI 0.683–2.470; p = 0.4246). In the patients belonging to subgroup analyses who received distal and total gastrectomy, the antiadhesion membrane was not associated with the incidence of SBO.ConclusionsAntiadhesion membrane did not decrease SBO occurrence rate after open gastrectomy. Therefore, the use of antiadhesion membrane would not be effective for preventing SBO in gastric cancer surgery.
Switching on/off phosphorescent or non‐radiative channels by aggregation‐induced quantum interference
Authors: Kong Yi , Wang Yu‐Chen , Huang Xunkun , Liang WanZhen , Zhao Yi 
Published: July 2023

AbstractPure organic materials with persistent and efficient room‐temperature phosphorescence have recently aroused great research interest due to their vast potential in applications. One crucial design principle for such materials is to suppress as much as possible the non‐radiative decay of the triplet exciton while maintaining a moderate phosphorescent radiative rate. However, molecular engineering often exhibits similar regulation trends for the two processes. Here, we propose that the quantum interference caused by aggregation can be utilized to control the phosphorescent and non‐radiative decay channels. We systematically analyze various constructive and destructive transition pathways in aggregates with different molecular packing types and establish clear relationships between the luminescence characters and the signs of the singlet and triplet excitonic couplings. It is shown that the decay channels can be flexibly switched on or off by regulating the packing type and excitonic couplings. Most importantly, an enhanced phosphorescent decay and a completely suppressed non‐radiative decay can be simultaneously realized in the aggregate packed with inversion symmetry. This work lays the theoretical foundation for future experimental realization of quantum interference effects in phosphorescence.
Flow behaviors of multiscale bubbles with porous ceramic membrane distributors: Visualization and modeling
Authors: Xiang Zhenli , Yin Chunyu , Wan Dongchuang , Zhou Yebin , Ma Chaofan , Jiang Mengmeng , He Wei , Liu Yi , Li Xiaonian , Lu Chunshan 
Published: July 2023

AbstractThe distribution of gas‐liquid two‐phase flow is one of the significant effects on heterogeneous catalytic reactions. Ceramic membrane gas distributors (CMGD) were applied in improving gas‐liquid distribution, and flow behavior of gas as dispersed phase in liquid phase was visualized via high‐speed photograph. The average diameters of multiscale bubbles were measured and modeled ranging from 10−5 to 10−2 m. The coalescence and trajectory of bubbles during rising process were observed, and two typical trajectories straight and spiral types were tracked. To inhibit coalescence of bubbles during rising process, internals manufactured by 3D printing were installed in the channel of ceramic membrane. The average bubble size of CMGD decreases 12% from 392 to 345 μm compared with that of the original CMGD. The CMGD with internals enhances the heterogeneous catalytic reaction performance via providing large quantity of stabile multiscale bubbles which could match the porous structure of catalyst.
Manipulation des intermetallischen Ladungstransfers zur Verbesserung der Wasseroxidations‐Elektrokatalyse durch externe Stimuli
Authors: Chalil Oglou Ramadan , Ulusoy Ghobadi Turkan Gamze , Hegner Franziska Simone , Galán‐Mascarós José Ramón , López Núria , Ozbay Ekmel , Karadas Ferdi 
Published: July 2023

AbstractViele elektrokatalytische Prozesse, insbesondere die Wasseroxidation (Oxygen Evolution Reaction, OER), stellen einen kinetischen Engpass dar. Dieser ist auf die Existenz linearer Skalierungsbeziehungen zurückzuführen, welche die Energieoptimierung der verschiedenen Zwischenprodukte des Reaktionsmechanismus begrenzen. Hier zeigen wir, wie wir diese Skalierungsbeziehungen mit Hilfe externer Stimuli durchbrechen können und dadurch die elektrokatalytische Aktivität einer mit Co−Fe‐Preußischblau modifizierten Elektrode erhöhen. Verbesserungen der OER von ≈11 % bzw. ≈57 % wurden unter Magnetfeld (0.2 T) und Lichteinstrahlung (100 mW cm−2) erzielt, wenn bei einem fixen Überpotential, η=0.6 V, bei pH 7 gearbeitet wurde. Die beobachteten Verbesserungen hängen stark mit der Intensität des intermetallischen Ladungstransfers (IMCT) zwischen Fe‐ und Co‐Zentren zusammen. Computersimulationen mit der Dichtefunktionaltheorie deuten darauf hin, dass eine Anpassung des IMCTs zu einer Änderung des Reaktionsmechanismus führen kann, bis hin zu einem auf externen Stimuli basierenden Spin‐Crossover‐Mechanismus.
Liposomale Enzym‐Nanoreaktoren auf Basis von Nanoconfinement für eine effiziente Anti‐Tumor‐Therapie
Authors: Wang Ran , Yu Yingjie , Gai Meiyu , Maroto Ana Mateos , Morsbach Svenja , Xia Xiang , He Maomao , Fan Jiangli , Peng Xiaojun , Landfester Katharina , Jiang Shuai , Sun Wen 
Published: July 2023

AbstractEnzymatische Reaktionen können endogene Nährstoffe eines Tumors verbrauchen und zytotoxische Spezies erzeugen und sind daher vielversprechende Werkzeuge für die Behandlung bösartiger Tumore. Inspiriert von der Natur, in der Enzyme in Membranen kompartimentiert sind, um eine hohe Reaktionseffizienz zu erreichen und biologische Prozesse von der Umwelt zu trennen, entwickelten wir liposomale Nanoreaktoren, die enzymatische Kaskadenreaktionen im wässrigen Nanoconfinement des Liposoms durchführen können. Die Nanoreaktoren hemmten das Tumorwachstum in vivo effektiv, indem sie Tumornährstoffe (Glukose und Sauerstoff) verbrauchten und hochgradig zytotoxische Hydroxylradikale (⋅OH) produzierten. Die Ko‐Kompartimentierung von Glukoseoxidase (GOx) und Meerrettichperoxidase (HRP) in Liposomen konnte die lokale Konzentration des Zwischenprodukts Wasserstoffperoxid (H2O2) sowie den Säuregrad aufgrund der Bildung von Gluconsäure durch GOx erhöhen. Sowohl H2O2 als auch der Säuregehalt beschleunigten die zweite Stufe der Reaktion durch HRP und verbesserten so die Gesamteffizienz der Kaskadenreaktion. Die biomimetische Kompartimentierung enzymatischer Tandemreaktionen in biokompatiblen Liposomen ist ein vielversprechender Weg für die Entwicklung katalytischer Nanomedikamente für die Antitumortherapie.
First long‐term study of live observations of loggerhead and leatherback turtles in southern Portugal with relevance for conservation
Authors: Castro Joana , Hughes Ashley Payne , Cid André , Patrício Ana Rita , Laborde Marina I. , Matos Fábio L. 
Published: July 2023

Abstract

Most of the information available on loggerhead turtles (Caretta caretta) and leatherback turtles (Dermochelys coriacea) for the southern coast of Portugal is based on stranding data, and to a less extent on telemetry data, with very little information derived from sightings of live animals.
This work reports sightings data of loggerhead and leatherback turtles off the south coast of Portugal collected during dedicated surveys on board a research boat, from 2016 to 2022.
The sightings data corrected for effort confirm the recurrent presence of loggerhead turtles in the study area, with a higher sightings rate in May and June. Conversely, leatherback turtles were only sporadically observed in some years.
This study highlights the importance of the southern waters of Portugal for loggerhead turtles as a recurrent area used by individuals of this species, probably from different origins within the North Atlantic and the Mediterranean, in line with previous studies.
The southern coast of Portugal, however, is heavily exploited by fisheries, and the main cause of death among sea turtles is bycatch. The results presented will therefore help inform future management measures aiming to reduce interactions with fisheries (e.g., limiting some fishing gears in the months with more sightings).
Since the study area is probably used by loggerhead turtles from different Regional Management Units, the impacts of conservation measures imposed locally may also have beneficial effects at a regional scale.
In‐situ PLL‐g‐PEG Functionalized Nanopore for Enhancing Protein Characterization
Authors: Salehirozveh Mostafa , Kure Larsen Anne‐Kathrine , Stojmenovic Milos , Thei Federico , Dong Mingdong 
Published: July 2023

AbstractSingle‐molecule nanopore detection technology has revolutionized proteomics research by enabling highly sensitive and label‐free detection of individual proteins. Herein, we designed a small, portable, and leak‐free flowcell made of PMMA for nanopore experiments. In addition, we developed anin situfunctionalizing PLL‐g‐PEG approach to produce non‐sticky nanopores for measuring the volume of diseases‐relevant biomarker, such as the Alpha‐1 antitrypsin (AAT) protein. Thein situfunctionalization method allows continuous monitoring, ensuring adequate functionalization, which can be directly used for translocation experiments. The functionalized nanopores exhibit improved characteristics, including an increased nanopore lifetime and enhanced translocation events of the AAT proteins. Furthermore, we demonstrated the reduction in the translocation event's dwell time, along with an increase in current blockade amplitudes and translocation numbers under different voltage stimuli. The study also successfully measures the single AAT protein volume (253 nm3), which closely aligns with the previously reported hydrodynamic volume. The real‐timein situPLL‐g‐PEG functionalizing method and the developed nanopore flowcell hold great promise for various nanopores applications involving non‐sticky single‐molecule characterization.
An Improved Synthesis of PN‐adamantanoid Cages P4(NR)6 and a Mechanistic Study of their Fourfold Oxidation
Authors: Land Michael A. , Ren Jincheng , Roberts Nicholas J. , Bamford Karlee L. , Shayan Mohsen , Kutulska Anastasiia , George Tanner , Masuda Jason D. , Chitnis Saurabh S. 
Published: July 2023

AbstractPhosphorus‐nitrogen (PN) adamantanoid cages are valuable precursors for materials chemistry, but their syntheses are based on harsh methods that sometimes require access to restricted reagents. We report a new and scalable synthesis of PN adamantanoid compounds by chlorosilane elimination between bis‐silylated amines and phosphorus trichloride. We further study the mechanism of the recently‐reported four‐fold oxidation of such cages with Me3SiN3 to yield tetravalent tetrahedral connectors for materials chemistry. Reaction monitoring and kinetic modelling revealed the key rate‐limiting step, but attempts to accelerate this using Lewis acid additives were unsuccessful. Nevertheless, a new four‐fold oxidized PN‐adamantanoid cage has been prepared and structurally characterized.
Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies
Authors: Zengin Gokhan , Mostafa Nada M. , Abdelkhalek Yasmin M. , Eldahshan Omayma A. 
Published: July 2023

AbstractRhoifolin (apigenin‐7‐O‐β‐neohesperidoside) belongs to the class of flavonoids and was reported to exhibit anti‐inflammatory, cytotoxic, antidiabetic, hepatoprotective, and cardioprotective activities. The current study presents the in‐vitro evaluation of the antioxidative effects of rhoifolin by many assays, namely DPPH, CUPRAC, ABTS, phosphomolybdenum, and FRAP. Enzyme inhibitory potential was also evaluated for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase enzymes. While results revealed weak antioxidant activities for rhoifolin, the compound demonstrated some promising enzyme inhibitory effects against BChE (4.03 mg GALAE/g) and tyrosinase (7.44 mg KAE/g) but was not active on AChE. Regarding anti‐diabetic enzymes, the compound was active on amylase but did not show any inhibition effect on glucosidase. In‐silico molecular docking study was performed for rhoifolin on the active site of NADPH oxidase, BChE, and amylase enzymes to verify the observed enzyme inhibitory effect. Good binding affinities were observed for rhoifolin on all the docked enzymes, revealing numerous hydrogen bonds, carbon‐hydrogen, van der Waals interactions. This is the first study to evaluate the enzyme inhibition potential of rhoifolin. We concluded that the increase in the degree of glycosylation might decrease the antioxidant abilities of flavonoids and that rhoifolin had moderate enzyme inhibition abilities to be investigated in future studies.