bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial
Authors: Sternberg Cora N. , Davis Ian D. , Mardiak Jozef , Szczylik Cezary , Lee Eunsik , Wagstaff John , Barrios Carlos H. , Salman Pamela , Gladkov Oleg A. , Kavina Alexander , Zarbá Juan J. , Chen Mei , McCann Lauren , Pandite Lini , Roychowdhury Debasish F. , Hawkins Robert E. 
Published: April 2023

Purpose Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and c-Kit. This randomized, double-blind, placebo-controlled phase III study evaluated efficacy and safety of pazopanib monotherapy in treatment-naive and cytokine-pretreated patients with advanced renal cell carcinoma (RCC). Patients and Methods Adult patients with measurable, locally advanced, and/or metastatic RCC were randomly assigned 2:1 to receive oral pazopanib or placebo. The primary end point was progression-free survival (PFS). Secondary end points included overall survival, tumor response rate (Response Evaluation Criteria in Solid Tumors), and safety. Radiographic assessments of tumors were independently reviewed. Results Of 435 patients enrolled, 233 were treatment naive (54%) and 202 were cytokine pretreated (46%). PFS was significantly prolonged with pazopanib compared with placebo in the overall study population (median, PFS 9.2 v 4.2 months; hazard ratio [HR], 0.46; 95% CI, 0.34 to 0.62; P < .0001), the treatment-naive subpopulation (median PFS 11.1 v 2.8 months; HR, 0.40; 95% CI, 0.27 to 0.60; P < .0001), and the cytokine-pretreated subpopulation (median PFS, 7.4 v 4.2 months; HR, 0.54; 95% CI, 0.35 to 0.84; P < .001). The objective response rate was 30% with pazopanib compared with 3% with placebo ( P < .001). The median duration of response was longer than 1 year. The most common adverse events were diarrhea, hypertension, hair color changes, nausea, anorexia, and vomiting. There was no evidence of clinically important differences in quality of life for pazopanib versus placebo. Conclusion Pazopanib demonstrated significant improvement in PFS and tumor response compared with placebo in treatment-naive and cytokine-pretreated patients with advanced and/or metastatic RCC.
Use of Prognostic Factors and Scores in Selection of Patients with Colorectal Cancer Peritoneal Metastasis (CRPM) for Cytoreductive Surgery and Intraperitoneal Chemotherapy (CRS/IPC): Results of an International Survey Among Oncologic Clinicians
Authors: Kozman Mathew A. , Fisher Oliver M. , Liauw Winston , Morris David L. 
Published: April 2023

Abstract
Background
No universally accepted guidelines exist for treatment of patients with colorectal cancer peritoneal metastases (CRPM) undergoing cytoreductive surgery and intraperitoneal chemotherapy (CRS/IPC). Several uncertainties remain concerning almost every aspect of this treatment modality, resulting in marked variability in patient management and likely outcomes. This survey aimed to define variations and trends in clinician decision making more clearly.

Methods
A 41-question web-based survey was distributed electronically via the Peritoneal Surface Oncology Group International (PSOGI), the International Society for the Study of Pleura and Peritoneum (ISSPP) as well as via social media (particularly Twitter). The survey sought to address and record clinician responses regarding patient workup/assessment, selection for preoperative systemic therapy, preoperative and intraoperative selection for CRS/IPC, and consideration of prognosis and complications.

Results
Complete responses were received from 60 clinicians from 45 centres in 22 countries. Upon assessment of survey responses, several interesting trends were noted in each section of the survey. Significant variability in surgeon practice and opinion were identified concerning almost every aspect of the treatment modality.

Conclusion
This international survey provides the most comprehensive insight into clinician decision-making trends regarding patient assessment, selection and management. This should allow areas of variability to be more clearly defined and could potentially prompt development of initiatives for achieving consensus and standardisation of care in the future.
Institutions for digital labour platforms: results of a study conducted in Poland
Authors: Ostoj Izabela 
Published: April 2023

Motivation: The development of labour platforms is one of the manifestations of the platformisation of the economy. Their growing popularity has revealed institutional vulnerabilities, particularly with regard to the weak position of platform workers, related to their ambiguous status, controversial regulations of labour platforms including algorithmic control of tasks performed, the rate and method of payment for services rendered, insufficient knowledge of how platforms operate. They are all the subject of intense discussion, also at the EU level.Aim: The identification of desired directions of changes in the institutional environment of labour platforms in Poland — as expected by the society — against the background of the ongoing discussion on this subject in other countries and at the EU level.Results: A diagnostic survey conducted on a large sample of Polish citizens aged 18–70 revealed that the most expected changes that would improve the quality of the institutional environment of labour platforms are: the introduction of a minimum payment for work services and the adoption of the independent worker status, the introduction of universal rules regulating digital platform operations, as well as the introduction of training and information materials on how labour platforms work. Poles attach less importance to the right of platform workers to establish trade unions.
Tirzepatide - a novel dual GLP-1 and GIP receptor agonist used in pharmacotherapy of obesity: A literature review
Authors: Stachyra Bartłomiej , Wolanin Marta , Stawikowski Cezary , Zielonka Bartłomiej , Osińska Aleksandra , Wolanin Izabela , Madej Karolina , Dengler Barbara , Kowalczyk Ilona , Krawiec Paulina 
Published: April 2023

Background: Obesity is a chronic disease, which along with its complications, poses a huge threat to both our health as individuals and our healthcare as a community.
Objective: The aim of this work is to review efficacy and safety of Tirzepatide, a novel dual GIP/GLP-1 receptor agonist in the treatment of obesity
Method: A literature review was conducted on databases such as PubMed and Google Scholar using terms “obesity”, “obesity treatment”, “glucagon-like peptide 1”, “Glucose-dependent insulinotropic polypeptide”, “Tirzepatide” as keywords. The review was performed in accordance with the PRISMA guidelines.
Results: Administration of tirzepatide once weekly provides a substantial and sustained reduction in bodyweight with little side effects.
Conclusions: Clinical trials showed both high efficacy and safety of Tirzepatide in management of obesity. Due to its novel, broadened mechanism of action it seems to be the most effective drug for reducing bodyweight available on the market. Tirzepatide could be our answer to tackling the problem of world-wide obesity epidemic.
Optimized Scenario Reduction: Solving Large-Scale Stochastic Programs with Quality Guarantees
Authors: Zhang Wei , Wang Kai , Jacquillat Alexandre , Wang Shuaian 
Published: April 2023

Stochastic programming involves large-scale optimization with exponentially many scenarios. This paper proposes an optimization-based scenario reduction approach to generate high-quality solutions and tight lower bounds by only solving small-scale instances, with a limited number of scenarios. First, we formulate a scenario subset selection model that optimizes the recourse approximation over a pool of solutions. We provide a theoretical justification of our formulation, and a tailored heuristic to solve it. Second, we propose a scenario assortment optimization approach to compute a lower bound—hence, an optimality gap—by relaxing nonanticipativity constraints across scenario “bundles.” To solve it, we design a new column-evaluation-and-generation algorithm, which provides a generalizable method for optimization problems featuring many decision variables and hard-to-estimate objective parameters. We test our approach on stochastic programs with continuous and mixed-integer recourse. Results show that (i) our scenario reduction method dominates scenario reduction benchmarks, (ii) our scenario assortment optimization, combined with column-evaluation-and-generation, yields tight lower bounds, and (iii) our overall approach results in stronger solutions, tighter lower bounds, and faster computational times than state-of-the-art stochastic programming algorithms.History: Accepted by Andrea Lodi, Area Editor for Design and Analysis of Algorithms–Discrete.Supplemental Material: The e-companion is available at https://doi.org/10.1287/ijoc.2023.1295 .
An Evaluation of Practice Supervisor Training for Student Paramedics
Authors: Jadzinski Megan , Hirdle Joanne 
Published: April 2023

Background: Registered health professionals have a responsibility to facilitate learning in the workplace and those who are supporting students should have the skills and knowledge to take on this role. Paramedics are now working in a variety of healthcare settings. Regulatory bodies recognise that students should have opportunities to develop their supervision skills before qualifying, so practice supervisor training was implemented into the final year curriculum at one university. Aim: To explore the value of incorporating practice supervisor training into the curriculum. Methods: Final-year student paramedics were provided with practice supervisor training as part of their degree. This training was delivered over three seminars before the students’ final preregistration placement. Students were invited to provide anonymous feedback via an evaluation form. Findings: A significant number of students felt prepared to take on the practice supervisor role when qualified. Conclusion: Practice supervisor training, when delivered as part of the curriculum, is of benefit to students.
Synthesis of Al–Sn alloys by direct chill casting under the effect of mechanical stirring: an experimental and simulation optimization study
Authors: Patel Deepak , Biswas Prasenjit , Mallik Archana , Das Sanjeev 
Published: April 2023

Abstract
Aluminium–tin (Al–Sn) immiscible alloys for bearing materials are difficult to cast by the conventional direct chill casting method. At higher concentrations, Sn accumulates at the bottom of the as-cast solid due to a significant density difference in Al and Sn. In the present investigation, Al–Sn alloys were fabricated by the direct chill (DC) casting method under the influence of mechanical forced convection (MFC). A computer-based simulation approach has been implemented to study the effect of MFC device position and impeller speed on melt flow and solidification. Optimized parameters were experimentally validated and the quality of as-cast ingots was evaluated. Hence, this optimization approach can be used to produce better quality Al–Sn bearing materials with uniformly distributed Sn phase in Al-matrix by the direct chill casting route.
Desde la documentación activa a la revitalización contextualizada: experiencias con comunidades kichwahablantes en Ecuador
Authors: Haboud Bumachar Marleen 
Published: April 2023

Resumen
Durante los últimos 30 años, Ecuador ha visto transformaciones importantes con respecto a las políticas relacionadas con las lenguas indígenas en el país. Por otra parte, estudiosos extranjeros y locales han llevado a cabo numerosas investigaciones lingüísticas y antropológicas sobre varias de las lenguas indígenas habladas en el país; sin embargo, estas han tenido bajo o ningún impacto en el mantenimiento de las lenguas, las mismas que muestran una tendencia persistente al desplazamiento. Enmarcado en prácticas de documentación activa-revitalización, este artículo se propone mostrar brevemente las tendencias de desplazamiento del kichwa en Ecuador, ilustrar y analizar procesos de investigación que basados en el quehacer colaborativo entre hablantes y no hablantes, pasan de ser una documentación que beneficia exclusivamente a la comunidad científica lingüística, para centrarse en los hablantes como los primeros agentes-beneficiarios de procesos revitalizadores; y describir algunas de las estrategias de revitalización que emergen de activistas kichwahablantes. Finalmente, reflexionaré brevemente sobre las metodologías utilizadas y la necesidad de avanzar hacia verdaderas prácticas de interculturalidad basadas en interrelaciones más equitativas que lleguen a impactar en los niveles micro, meso y macro.
Should Wrongfulness be Required or is Fault Enough? Arts 1:101, 4:101 ff PETL
Authors: Knetsch Jonas 
Published: April 2023

Abstract
When drafting the Principles of European Tort Law (PETL), the members of the European Group on Tort Law decided to omit wrongfulness as a specific requirement for civil liability, considering it as a concept underlying the notions of interference with legally protected interests and the standard of conduct. This paper tends to demonstrate that this terminological and conceptual choice is still valid eighteen years after the publication of the PETL. On the basis of two case studies examined under German and French law, it is suggested that national traditions are too disparate to adopt a common understanding of what wrongfulness exactly means to a tort lawyer in Europe. The irreconcilability of the different interpretations becomes particularly apparent in mixed tort law systems, such as Japan or Belgium, where the French and the German approach struggle to coexist.
Recent advances in the genetics of alopecia areata
Authors: Buket Basmanav F. , Betz Regina C. 
Published: April 2023

Abstract
Alopecia areata (AA) is a common autoimmune-mediated hair loss disorder in humans with an estimated lifetime risk of approximately 2 %. Episodes of hair loss usually begin with isolated hairless patches that may progress to complete hair loss over the entire body. A familial occurrence of AA is well established, with recurrence risks of about 6–8 % in first-degree relatives. AA is a multifactorial disorder involving both environmental and genetic risk factors. Previous research has identified 14 susceptibility loci, most of which implicate genes involved in the immune response. The following review presents a summary of the latest findings from genome-wide association, sequencing and gene expression studies of AA, as well as their contribution to the recent therapeutic developments.
Syndromic ichthyoses
Authors: Fischer Judith , Hotz Alrun , Komlosi Katalin 
Published: April 2023

Abstract
Inherited ichthyoses are classified as Mendelian disorders of cornification (MEDOC), which are further defined on the basis of clinical and genetic features and can be divided into non-syndromic and syndromic forms. To date, mutations in more than 30 genes are known to result in various types of syndromic ichthyoses, which, in addition to mostly generalised scaling and hyperkeratosis of the skin, also show additional organ involvement. The syndromic ichthyoses are generally very rare and are classified based on the mode of inheritance, and can be further subdivided according to the predominant symptoms.
In our review we provide a concise overview of the most prevalent syndromic forms of ichthyosis within each subgroup. We emphasize the importance of the clinical assessment of complex syndromes even in the era of genetic testing as a first-tier diagnostic and specifically the need to actively assess potential organ involvement in patients with ichthyosis, thereby enabling efficient diagnostic and therapeutic approaches and timely access to specialized centers for rare disorders of cornifications. As part of the Freiburg Center for Rare Diseases a Center for Cornification Disorders was recently established with collaboration of the Institute of Human Genetics and the Department of Dermatology.
An early diagnosis of syndromes will be of direct benefit to the patient regarding interventional and therapeutic measures e. g. in syndromes with cardiac or metabolic involvement and allows informed reproductive options and access to prenatal and preimplantation genetic diagnosis in the family.
STUDI EKSPERIMENTAL PENGARUH KECEPATAN SUPERFISIAL ALIRAN SEARAH TERHADAP KARAKTERISTIK DAN PARAMETER ALIRAN STRATIFIED PADA PIPA HORIZONTAL
Authors: Mahadiputra Adolvin Arnol , Karnowo Karnowo , Anis Samsudin 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pengaruh kecepatan superfisial liquid (VSL) dan kecepatan superfisial gas (VSG) terhadap karakteristik (visualisasi pola aliran stratified, frekuensi hydraulic jump dan kecepatan hydraulic jump) dan parameter (fraksi hampa, liquid holdup dan gradien penurunan tekanan) pola aliran stratified pada aliran airudarapipa horizontal. Metode yang digunakan adalah eksperimental dengan pengujian variasi kecepatan superfisial liquid (VSL) dan kecepatan superfisial gas (VSG) yang dianalisa menggunakan metode image processing. Pengambilan data menggunakan high speed video camera dengan kecepatan 400 fps. Penelitian ini menggunakan pipa acrylic transparan berdiameter dalam 19 mm dan mempunyai penampang berbentuk lingkaran. Posisi pipa dalam keadaan horisontal dengan fluida air sebagai liquid dan udara sebagai gas. Penelitian ini dilakukan dengan asumsi temperatur ruang konstan. Hasil penelitian diperoleh kecepatan superfisial liquid dan gas yang optimal untuk menghindari hydraulic jump pada pengaplikasian industri dengan peningkatan maksimal kecepatan superfisial liquid (VSL) adalah 0,064 mâ„s dan kecepatan superfisial gas (VSG) adalah 3,254 mâ„s, untuk peningkatan VSL= 0,050 mâ„s maksimal peningkatan VSG = 4,140 mâ„. Penelitian ini menjelaskan perubahan kecepatan superfisial liquid (VSL) dan kecepatan superfisial gas (VSG) mempengaruhi karakteristik dan paramater pola aliran stratified. Hal ini ditunjukkan dengan berubahnya visualisasi bentuk pola aliran, nilai frekuensi hydraulic jump, kecepatan hydraulic jump, fraksihampa, liquid holdup dan gradien tekanan.
T-sejtes nagy granuláris lymphocytás leukémia ezer arca és sikeres kezelése
Authors: Kovács Szilamér , Szabó Zsuzsanna , Iványi János László , Szendrei Tamás , Plander Márk 
Published: April 2023

Bevezetés
A T-sejtes nagy granuláris lymphocytás leukémia egy ritka, rett T-sejtes neoplázia, mely változatos klinikai lefolyást mutat és gyakran társul autoimmun szövődményekkel.

Esetismertetés
Idős férfi betegünknél lymphocytosis és neutropenia hátterében igazolt T-LGLL mellett több autoimmun betegség is kialakult, mint gluténérzékenység, primer biliáris cirrhosis, tiszta vörösvértest-aplázia. A súlyos, rendszeres vörösvértest-transzfúziót igénylő tiszta vörösvértest-aplázia a standard immunszuppreszív gyógyszerekre refrakternek bizonyult, végül alemtuzumab hatására remisszióba került.

Megbeszélés
Bemutatjuk a T-LGLL-ben előforduló autoimmun szövődmények pathomechanizmusát, illetve röviden tárgyaljuk a refrakter esetek kezelési lehetőségeit.
Transient expression and purification of S2 protein from porcine epidemic diarrhea virus in plants
Authors: Ho Thuong Thi , Trinh Vy Thai , Hoang Hang Thi Thu , Pham Ngoc Bich , Chu Ha Hoang 
Published: April 2023

Porcine epidemic diarrhea (PED), caused by the Porcine epidemic diarrhea virus (PEDV), is an acute, highly contagious disease of pigs of all ages, especially piglets under one week old, with the mortality rate reaching 95–100%. Developing an effective vaccine against PEDV in Vietnam is urgent. Spike protein containing S1 and S2 subunits is considered the main target for vaccine development, and the S2 subunit contains immunodominant neutralizing epitopes of PEDV. To date, the expression of S2 protein in plants has not been reported and evaluated. In this study, the gene encoding the S2 subunit of a PEDV strain belonging to genotype 2a was amplified, sequenced, and inserted in a pRTRA vector containing the GCN4pII (pII) motif. The plant expression cassette containing S2-pII was then inserted into the pCB301 vector. The Agrobacterium tumefaciens harboring the pCB301-S2-pII vector was transformed into Nicotiana benthamiana leaves via agroinfiltration. The accumulation level of S2-pII protein in tobacco leaves was semi-quantified by Western blot, accounting for approximately 86.7 mg/kg of fresh leaves and 1.47% total soluble protein, which was 294-fold higher than the accumulation level of S1-pII protein in our previous publication. S2-pII protein was successfully purified by immobilized metal affinity chromatography (IMAC). The oligomeric state of S2-pII protein was characterized by size exclusion chromatography (SEC). The S2-pII protein was determined to be a multimer protein with a high molecular weight. These results are the basis for more extended studies to develop a plant-based S2 vaccine against PEDV infection.
UTILIZATION OF SLAG POWDER AND RECYCLED CONCRETE WASTES IN REACTIVE POWDER CONCRETE
Authors: N Sakthieswaran , Shiny Brintha G. 
Published: April 2023

Using recycled wastes and industrial by-products in construction materials has become mandatory to conserve the natural resources and manage waste-disposal environmental problems. This experimental work investigates the workability and strength properties of reactive powder concrete (RPC), utilizing slag powder and finely ground recycled concrete waste as the partial substitutes for cement and quartz sand, respectively. The results for the slump flow, flexural strength, compressive strength, split-tensile strength were analysed for varying contents of the recycled concrete waste in RPC, i.e., (0, 5, 10, 15, 20, 25 and 30) % and a constant slag-powder addition of 20 %. Furthermore, water absorption of the hardened specimens of 28 d of curing was also examined. The results indicated a rise in the water absorption and reduced workability with the increase in the content of recycled concrete in RPC. This was due to porous inter-particle voids in recycled concrete wastes. The strength properties of RPC exhibited superior performance for the substitution of 15 % of quartz sand with recycled concrete waste. A low water-cement ratio and a steel-fibre addition to RPC play an important role in the strength development and durability properties of RPC.
Review of Hybrid Solar-Biomass Power Generation System
Authors: Waqar Mohd , Shukla Anoop Kumar , Sharma Meeta , Maheswari Mayank , Nandan Gopal 
Published: April 2023

The present paper reviewed the studies of the hybrid solar-biomass power plants. Based on renewable energy, several configurations of hybrid power cycles are discussed and summarized. It includes the technical, economical, and environmental aspects of the hybrid solar-biomass plant, how the hybrid power plant works, and the essential resources required for the setup and running of the hybrid solar biomass plant. The advantages and disadvantages associated with the single renewable resource-based power plants are also discussed. The hybrid power plants help rectify the disadvantages over single resource plants, improve the power production rate of the plant, and help it run over seasonally. The present paper also discussed the solar and biomass potential in the Indian context and compared the progress of the hybrid solar-biomass power generation system with other countries.