bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue
Authors: Wen Bo , Dai Yuguo , Han Xue , Huo Fangjun , Xie Li , Yu Mei , Wang Yuru , An Ning , Li Zhonghan , Guo Weihua 
Published: February 2023

AbstractMaxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca2+·COO− coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.
Variational quantum approximate support vector machine with inference transfer
Authors: Park Siheon , Park Daniel K. , Rhee June-Koo Kevin 
Published: February 2023

AbstractA kernel-based quantum classifier is the most practical and influential quantum machine learning technique for the hyper-linear classification of complex data. We propose a Variational Quantum Approximate Support Vector Machine (VQASVM) algorithm that demonstrates empirical sub-quadratic run-time complexity with quantum operations feasible even in NISQ computers. We experimented our algorithm with toy example dataset on cloud-based NISQ machines as a proof of concept. We also numerically investigated its performance on the standard Iris flower and MNIST datasets to confirm the practicality and scalability.
On the potential of transauricular electrical stimulation to reduce visually induced motion sickness
Authors: Molefi Emmanuel , McLoughlin Ian , Palaniappan Ramaswamy 
Published: February 2023

AbstractPerturbations in the autonomic nervous system occur in individuals experiencing increasing levels of motion sickness. Here, we investigated the effects of transauricular electrical stimulation (tES) on autonomic function during visually induced motion sickness, through the analysis of spectral and time-frequency heart rate variability. To determine the efficacy of tES, we compared sham and tES conditions in a randomized, within-subjects, cross-over design in 14 healthy participants. We found that tES reduced motion sickness symptoms by significantly increasing normalized high-frequency (HF) power and decreasing both normalized low-frequency (LF) power and the power ratio of LF and HF components (LF/HF ratio). Furthermore, behavioral data recorded using the motion sickness assessment questionnaire (MSAQ) showed significant differences in decreased symptoms during tES compared to sham condition for the total MSAQ scores and, central and sopite categories of the MSAQ. Our preliminary findings suggest that by administering tES, parasympathetic modulation is increased, and autonomic imbalance induced by motion sickness is restored. This study provides first evidence that tES may have potential as a non-pharmacological neuromodulation tool to keep motion sickness at bay. Thus, these findings may have implications towards protecting people from becoming motion sick and possible accelerated recovery from the malady.
Sex-specific differences in resting-state functional brain activity in pediatric concussion
Authors: Sharma Bhanu , Nowikow Cameron , DeMatteo Carol , Noseworthy Michael D. , Timmons Brian W. 
Published: February 2023

AbstractPediatric concussion has a rising incidence and can lead to long-term symptoms in nearly 30% of children. Resting state functional magnetic resonance imaging (rs-fMRI) disturbances are a common pathological feature of pediatric concussion, though no studies have explicitly examined sex-differences with respect to this outcome, precluding a sex-specific understanding of the functional neuropathology of pediatric concussion. Therefore, we performed a secondary data analysis of rs-fMRI data collected on children with concussion (n = 29) recruited from in a pediatric hospital setting, with greater than 12:1 matched control data accessed from the open-source ABIDE-II database. Seed-based and region of interest (ROI) analyses were used to examine sex-based rs-fMRI differences; threshold-free cluster enhancement (TFCE) and a family-wise error (FWE) corrected p-values were used to identify significantly different clusters. In comparing females with concussion to healthy females, groupwise differences were observed irrespective of seed selected. Notably, we observed (in order of largest effect) hypo-connectivity between the anterior cingulate cortex of the salience network and the thalamus and precuneus (TFCE = 1473.5, p-FWE < 0.001) and the cingulate gyrus (TFCE = 769.3, p-FWE = 0.009), and the seed (posterior cingulate cortex (PCC)) of the default mode network and the paracingulate gyrus (TFCE = 1275.7, p-FWE  < 0.001), occipital pole right (TFCE = 1045.0, p-FWE = 0.001), and sub-callosal cortex (TFCE = 844.9, p-FWE = 0.005). Hyper-connectivity was observed between the salience network seed and the cerebellum (TFCE = 1719.3, p-FWE < 0.001) and the PCC and the thalamus (TFCE = 1198.3, p-FWE < 0.001), cuneal cortex (1070.9, p-FWE = 0.001), and lateral occipital cortex left (TFCE = 832.8, p-FWE = 0.006). ROI analyses showed 10 and 5 significant clusters of hypo- and hyper-connectivity in females, respectively. Only one cluster of difference was found between males with concussion and healthy males on seed-based analyses, and 3 clusters on ROI analyses. There are alterations in rs-fMRI in females with concussion at one-month post-injury that are minimally present in males, which provides further evidence that recovery timelines in pediatric concussion may differ by sex.
Reliability and validity of OpenPose for measuring hip-knee-ankle angle in patients with knee osteoarthritis
Authors: Saiki Yoshitomo , Kabata Tamon , Ojima Tomohiro , Kajino Yoshitomo , Inoue Daisuke , Ohmori Takaaki , Yoshitani Junya , Ueno Takuro , Yamamuro Yuki , Taninaka Atsushi , Kataoka Tomoyuki , Kubo Naoyuki , Hayashi Seigaku , Tsuchiya Hiroyuki 
Published: February 2023

AbstractWe aimed to assess the reliability and validity of OpenPose, a posture estimation algorithm, for measuring hip-knee-ankle (HKA) angle in patients with knee osteoarthritis, by comparing it with radiography. In this prospective study, we analysed 60 knees (30 patients) with knee osteoarthritis. We measured HKA angle using OpenPose and radiography before or after total knee arthroplasty and assessed the test–retest reliability of each method with intraclass correlation coefficient (1, 1). We evaluated the ability to estimate the radiographic measurement values from the OpenPose values using linear regression analysis and used intraclass correlation coefficients (2, 1) and Bland–Altman analyses to evaluate the agreement and error between OpenPose and radiographic measurements. OpenPose had excellent test–retest reliability (intraclass correlation coefficient (1, 1) = 1.000) and excellent agreement with radiography (intraclass correlation coefficient (2, 1) = 0.915), with regression analysis indicating a large correlation (R2 = 0.865). OpenPose also had a 1.1° fixed error and no systematic error when compared with radiography. This is the first study to validate the use of OpenPose for the estimation of HKA angle in patients with knee osteoarthritis. OpenPose is a reliable and valid tool for measuring HKA angle in patients with knee osteoarthritis. OpenPose, which enables non-invasive and simple measurements, may be a useful tool to assess changes in HKA angle and monitor the progression and post-operative course of knee osteoarthritis. Furthermore, this validated tool can be used not only in clinics and hospitals, but also at home and in training gyms; thus, its use could potentially be expanded to include self-assessment/monitoring.
Estimation of optimal tilt angles for photovoltaic panels in Egypt with experimental verifications
Authors: Abdelaal Ashraf K. , El-Fergany Attia 
Published: February 2023

AbstractThe principal target of this work is to compute the optimal tilt angle (OTA) for Photovoltaic (PV) panels. To perform this task, comprehensive simulations are done starting from altering the tilt angle (TA) daily, to use one fixed TA for all the year. The mathematical models for extra-terrestrial radiation (ETR) of both horizontal and inclined surfaces are presented firstly. At a later stage, the optimization formulation for the maximizing the solar radiation (SR) is adapted, and then the daily, monthly, seasonally, half-yearly and optimal fixed TAs are obtained. Although, the daily OTA produces the maximum SR, it is costly and impractical. It is found that altering the TA twice a year at optimal values that are computed as 5° and 50° for Suez city, gives the best results that are very near to the daily altering of the OTA. The difference between the two methods is 1.56% which is very small. Also, the two OTAs has SR better than that of the fixed OTA which is 28° by 7.77%. Also, it is found that the yearly fixed OTA (28°) is nearly equal to the latitude angle of Suez city which is 30°. The two OTAs method of this paper is different from the commonly used method that suggests two TAs. The first TA is used for winter months which is obtained by adding 15° to the latitude angle while the second TA is obtained by subtracting 15° from the latitude angle for the summer months. This commonly used method produces lesser SR than the two OTAs method of this paper. The theoretical work has been proved by an experimental work on two PV systems constructed at 25° and 30° TAs. The results of the experimental work agree with the theoretical results.
Theoretical investigation of the MXene precursors MoxV4-xAlC3 (0 ≤ x ≤ 4)
Authors: Moreno-Armenta Ma. Guadalupe , Guerrero-Sánchez J. , Gutiérrez-Ojeda S. J. , Fernández-Escamilla H. N. , Hoat D. M. , Ponce-Pérez R. 
Published: February 2023

AbstractBy first-principles total-energy calculations, we investigated the thermodynamic stability of the MAX solid solution MoxV4-xAlC3 in the 0 ≤ x ≤ 4 range. Results evidence that lattice parameter a increases as a function of Mo content, while the c parameter reaches its maximum expansion at x = 2.5. After that, a contraction is noticed. Mo occupies VI sites randomly until the out-of-plane ordered Mo2V2AlC3 alloy is formed. We employed the Defect Formation Energy (DFE) formalism to evaluate the thermodynamic stability of the alloys. Calculations show five stable compounds. At V-rich conditions and from Mo-rich to Mo-moderated conditions, the pristine V4AlC3 MAX is stable. In the region of V-poor conditions, from Mo-rich to Mo-moderated growth conditions, the solid solutions with x = 0.5, 1, and 1.5 and the o-MAX Mo2V2AlC3 are thermodynamically stable. The line profiles of the Electron Localization Function and Bader charge analysis show that the V-C interaction is mainly ionic, while the Mo-C is covalent. Also, the exfoliation energy to obtain a MXene layer is ~ 0.4 eV/Å2. DFE also shows that MXenes exfoliated from the MAX phase with the same Mo content and atomic arrangement are thermodynamically stable. Our results get a deeper atomic scale understanding of the previously reported experimental evidence.
Monitoring and immunogenicity of SARS-CoV-2 vaccination of laboratory rhesus monkeys (Macaca mulatta)
Authors: Oh Dan Qi Priscilla , Grothe Iris , Lukaß Herbert , Kreiter Andreas K. , Hoffmann Markus , Wegener Detlef 
Published: February 2023

AbstractThe availability of effective vaccines and a high vaccination rate allowed the recent mitigation, or even withdrawal, of many protective measures for containing the SARS CoV-2 pandemic. At the same time, new and highly mutated variants of the virus are found to have significantly higher transmissibility and reduced vaccine efficacy, thus causing high infection rates during the third year of the pandemic. The combination of reduced measures and increased infectivity poses a particular risk for unvaccinated individuals, including animals susceptible to the virus. Among the latter, non-human primates (NHPs) are particularly vulnerable. They serve as important models in various fields of biomedical research and because of their cognitive capabilities, they receive particular attention in animal welfare regulations around the world. Yet, although they played an extraordinarily important role for developing and testing vaccines against SARS-CoV-2, the protection of captive rhesus monkeys against Covid-19 has rarely been discussed. We here report upon twofold mRNA vaccination of a cohort of 19 elderly rhesus monkeys (Macaca mulatta) against infection by SARS-CoV-2. All animals were closely monitored on possible side effects of vaccination, and were tested for neutralising antibodies against the virus. The data show that vaccination of rhesus monkeys is a safe and reliable measure to protect these animals against SARS-CoV-2.
Interpersonal variability of the human gut virome confounds disease signal detection in IBD
Authors: Stockdale Stephen R. , Shkoporov Andrey N. , Khokhlova Ekaterina V. , Daly Karen M. , McDonnell Siobhan A. , O’ Regan Orla , Nolan James A. , Sutton Thomas D. S. , Clooney Adam G. , Ryan Feargal J. , Sheehan Donal , Lavelle Aonghus , Draper Lorraine A. , Shanahan Fergus , Ross R. Paul , Hill Colin 
Published: February 2023

AbstractViruses are increasingly recognised as important components of the human microbiome, fulfilling numerous ecological roles including bacterial predation, immune stimulation, genetic diversification, horizontal gene transfer, microbial interactions, and augmentation of metabolic functions. However, our current view of the human gut virome is tainted by previous sequencing requirements that necessitated the amplification of starting nucleic acids. In this study, we performed an original longitudinal analysis of 40 healthy control, 19 Crohn’s disease, and 20 ulcerative colitis viromes over three time points without an amplification bias, which revealed and highlighted the interpersonal individuality of the human gut virome. In contrast to a 16 S rRNA gene analysis of matched samples, we show that α- and β-diversity metrics of unamplified viromes are not as efficient at discerning controls from patients with inflammatory bowel disease. Additionally, we explored the intrinsic properties of unamplified gut viromes and show there is considerable interpersonal variability in viral taxa, infrequent longitudinal persistence of intrapersonal viruses, and vast fluctuations in the abundance of temporal viruses. Together, these properties of unamplified faecal viromes confound the ability to discern disease associations but significantly advance toward an unbiased and accurate representation of the human gut virome.
Improving O&M decision tools for offshore wind farm vessel routing by incorporating weather uncertainty
Authors: Hadjoudj Yannis , Pandit Ravi Kumar 
Published: February 2023

AbstractThe growth of offshore wind farms depends significantly on how well offshore wind turbines (OWTs) are operated and maintained in the long term. The operation and maintenance (O&M) activities for offshore wind are relatively more challenging due to uncertain environmental conditions than onshore and due to this, vessel routing for offshore on‐site repair is remain complex and unreliable. Here, an improved data‐driven decision tool is proposed to robust the vessel routing for O&M tasks under numerous environmental conditions. A novel data‐driven technique based on operational datasets is presented to incorporate weather uncertainties, such as wind speed, wave period and wave height (significantly influence offshore crew repair works), into the O&M decision‐making process. Results show: (1) The inclusion of weather conditions improves the O&M model uncertainty and accuracy, (2) the implementation of a model allowing weather conditions to evolve has been added to vary the probabilities of successful transfers throughout the day, and (3) the reduction of risk of transfer failure by 15%. These conclusions are further supported by the performance error metrics and uncertainty calculations. Last but not least, by generating a variety of policies for consideration, this tool gave wind turbine operators a systematic and transparent way to evaluate trade‐offs and enable choices pertaining to offshore O&M. The full paper highlights the strengths and weaknesses of the proposed technique for offshore vessel routing as well as how the environmental conditions affect them.
Factor XI Inhibitors in Early Clinical Trials: A Meta-analysis
Authors: Galli Mattia , Laborante Renzo , Ortega-Paz Luis , Franchi Francesco , Rollini Fabiana , D'Amario Domenico , Capodanno Davide , Tremoli Elena , Gibson Charles Micheal , Mehran Roxana , Angiolillo Dominick J. 
Published: February 2023

Background Phase II randomized controlled trials (RCTs) on factor(F)XI inhibitors have shown promising results but they were burdened by low statistical power for clinical outcomes.
Methods We performed a systematic review and meta-analysis of RCT comparing FXI inhibitors versus other anticoagulants (enoxaparin or direct oral anticoagulants, DOACs) or versus placebo on top of antiplatelet therapy.
Results Eight RCTs testing FXI inhibitors (ISIS 416858, osocimab, abelacimab, milvexian, asundexian) and enrolling 9,216 patients were included. Compared with enoxaparin, FXI inhibitors were associated with reduced any-bleeding (risk ratio [RR]: 0.49, 95% confidence interval [CI]: 0.31–0.77), no difference in major bleeding (RR: 0.96, 95% CI: 0.41–2.28), and reduced trial-defined efficacy endpoint (RR: 0.62, 95% CI: 0.49–0.79), the latter driven by the high-dose regimens. Compared with DOACs, FXI inhibitors were associated with a trend toward reduced any-bleeding (RR: 0.66, 95% CI: 0.31–1.38) and no difference in major bleeding (RR: 1.03, 95% CI: 0.22–4.78) or in trial-defined efficacy endpoint (RR: 1.23, 95% CI: 0.88–1.70). Compared with placebo, FXI inhibitors were associated with increased any-bleeding (RR: 1.25, 95% CI: 1.08–1.43) and a trend toward increased major bleeding (RR: 1.21, 95% CI: 0.75–1.93), both driven by high-dose regimens, with no difference in trial-defined efficacy endpoint (RR: 1.02, 95% CI: 0.92–1.13).
Conclusion Results of this meta-analysis on FXI inhibitors suggest increased safety and efficacy compared with enoxaparin and modest increased safety compared with DOACs. The use of FXI inhibitors in adjunct to antiplatelet therapy versus placebo appears to be associated with a dose-dependent increase in bleeding without any difference in efficacy.
Study registration This study is registered in PROSPERO (CRD42022367706).
Split-Lobe for Tumor between Left S3 and S4 by Uniportal Video-Assisted Thoracoscopy
Authors: Wang KangNing , Wei Xing , Fang Qiang 
Published: February 2023

AbstractVideo-assisted thoracoscopic surgery (VATS) segmentectomy is an optimal treatment for malignant pulmonary ground glass nodules (GGNs). However, this surgery is complicated when tumors are located between more than two adjacent segments, although combined subsegmentectomy ensures sufficient margin under uniportal approach. Lobectomy might be inevitable, especially when resecting deep nodules in the central left upper lung lobe. Here, we present cases wherein we performed uniportal VATS (UVATS) resection for GGNs located between borders of left S3 and S4, with three-dimensional reconstruction conducted before surgery. The strategy of resecting central tumors in the left upper lung lobe between left S3 and S4 via UVATS is simple and feasible.
Surgery of a Giant Coronary Sinus Aneurysm Resulting from a Coronary Artery Fistula
Authors: Diab Nawras , Barghout Mohamed , Kueri Sami , Soschynski Martin , Siepe Matthias 
Published: February 2023

AbstractCoronary artery fistula (CAF), complicated by the aneurysmal formation of the coronary sinus (CS), is a very rare form of CAF. Here we report a case of a 60- year-old woman with a giant aneurysm of the CS resulting from the right coronary artery (RCA) fistula. The patient was highly symptomatic with dyspnea due to compression of cardiac chambers. CS reconstruction was performed using a pericardial patch after directly closing the fistula from the RCA to the CS.
Zurich Mini Cementless Total Hip Arthroplasty in 42 Small Breed Dogs and 8 Cats: Surgical Technique and Outcomes
Authors: Vezzoni Aldo , Boano Simona , Sacristani Alyssa , Bresina Stephen , Lanz Otto I. 
Published: February 2023

AbstractThis report aims to describe implant characteristics and procedure for implantation, and comment on and report the clinical outcomes in small dogs and cats using the new Zurich mini cementless total hip system. This study involved 8 cats and 42 dogs, with 3 cats and 6 dogs having bilateral total hip arthroplasties (THA). The mean body weight for cats was 6.5 kg, and the mean body weight for dogs was 9.2 kg. In the group of THAs in cats, capital physeal fracture was the reason for performing a THA in six cases (60%), hip dysplasia was the underlying reason in four cases (30%) and hip luxation in one case (10%). Among the 48 THAs in dogs, hip dysplasia was the underlying cause for performing THA in 27 cases (56%), avascular necrosis of the femoral head in 12 cases (25%), traumatic luxation with underlying hip dysplasia in 4 cases (8.5%), capital physeal fracture in 4 cases (8.5%), and traumatic femoral head fracture in 1 adult dog (2%). Seven postoperative complications were encountered, and all were solved without the need for explanting the prosthesis, except in one case because of the owner's decision. In conclusion, the Zurich mini cementless total hip system performed well in this study, with most dogs and cats having an excellent outcome and no patient being too small for the available implant sizes.