bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering the association between the Life’s Essential 8 and infertility: insights into depression, inflammation, and metabolic mediation
Authors: Cui Shichao , Li Li , Qin Weibing , Liu Wensheng , Zhong Xingming 
Published: February 2025

BackgroundThe Life’s Essential 8 (LE8) score has been associated with various health outcomes, but its relationship with female infertility remains unclear.MethodsThis study investigated the relationship between LE8 and infertility in women aged 20-45 years using the National Health and Nutrition Examination Survey (NHANES) data from 2013 to 2020. Weighted multifactorial logistic regression models were utilized to examine the association between the LE8 factors and their two subgroups [health behavior score (HBS) and health factor score (HFS)], as well as depressive status and infertility. Nonlinear relationships were examined using weighted restricted cubic spline (RCS) regression. Subgroup analysis and mediation analysis of depression, metabolic, and inflammation further elucidated the relationships. Sensitivity analysis was conducted to ensure the robustness of the findings.ResultsA total of 2,182 participants were included in this study, with 304 in the infertility cohort. Multifactorial regression analysis revealed significant negative correlations between LE8 and its subgroup HFS with infertility. Among the eight subscales, scores for sleep health, body mass index, and blood glucose were significantly negatively correlated with depression, while Patient Health Questionnaire-9 (PHQ-9) scores showed a positive correlation with infertility. Weighted RCS regression modeling indicated no nonlinear relationships between LE8, depression, HFS, HBS, and infertility. Mediation analyses suggested that depression scores, systemic immune inflammation index (SII), and uric acid (UA) mediated the association between LE8 and infertility.ConclusionHigher LE8 scores, indicating better cardiovascular health, are associated with lower depression scores and reduced levels of SII and UA. These factors collectively contribute to a lower risk of infertility in women. Targeted interventions aimed at enhancing cardiovascular health may potentially mitigate infertility risk through these pathways.
Ultrasonography reference values for the calcaneus in children and adolescents living at high altitude in Peru
Authors: Fuentes-López Jose , Vidal-Espinoza Rubén , Mamani-Luque Ofelia , Ibanez-Quispe Vladimiro , Villegas-Abrill Claudia , Canqui-Flores Bernabé , Mendoza-Mollocondo Charles Ignacio , Sanchez-Macedo Lucila , Cossio-Bolaños Marco , Gomez-Campos Rossana 
Published: February 2025

ObjectiveThe evaluation of bone health during the growth stage is extremely important, as it is a key factor to prevent bone diseases in adulthood. The objectives of the study were: a) to verify if there are differences in bone health with other geographic regions, b) to develop bone health curves using quantitative ultrasonography (QUS) through the Broadband Ultrasonic Attenuation (BUA) parameter in children and adolescents residing in a high altitude region of Peru and c) to determine specific cut-off points for bone health assessment in this particular population.MethodsA cross-sectional study was carried out in schoolchildren in a high altitude region of Peru. The sample consisted of 1468 children and adolescents (724 males and 744 females). The age range was 6.0 to 17.9 years old. Weight and height were evaluated. Body Mass Index (BMI) was calculated. Bone quality was evaluated by quantitative ultrasonography (QUS) of the calcaneus. The parameters measured were Speed of Sound (SOS, m/s); Broadband Ultrasonic Attenuation (BUA, dB/MHz); and Bone Quality Index (BQI= αSOS+αBUA, αβ: temperature corrections).ResultsThere were small discrepancies in bone health (BUA) between studies from various geographic regions. Values differed across all age ranges from ~0.36 to ~10.86 in males and from ~0.26 to ~6.68 in females. At later ages during adolescence the values are relatively similar, reaching a plateau around 16 and 17 years of age. Percentiles were calculated for BUA by age and sex. Sensitivity and specificity values in females are slightly higher relative to males. However, the Youden Index reflects 0.84 for both sexes and the appropriate cut-off point for men is ≤67.8 and for women is ≤63.7.ConclusionThe study demonstrated that there are small discrepancies in bone health (BUA) among children between children and adolescents from different geographic regions. These findings support the creation of specific references and cut-off points for bone health in the pediatric population of a high altitude region of Peru. The results suggest the application of percentiles for the assessment of bone health in school and epidemiological contexts.
Outcomes of mini-monovision with monofocal, enhanced monofocal and extended depth-of-focus intraocular lenses
Authors: Levy Issac , Shah Rachana Prashant , Mukhija Ritika , Nanavaty Mayank A. 
Published: February 2025

PurposeMini-monovision is a vision correction technique that allows for a broader spectrum of spectacle independence while minimizing anisometropia. This systemic review aims to evaluate the clinical outcomes of pseudophakic mini-monovision with three types of intraocular lenses (IOLs): monofocal, enhanced monofocal, and extended depth of focus (EDOF).MethodsA comprehensive literature search was conducted using PubMed and MEDLINE to identify studies reporting mini-monovision outcomes within the three categories of IOLs up to July 2024. Inclusion criteria were studies with more than 20 patients, target refraction to achieve mini-monovision difference in the fellow eye, and minimum follow-up of 3 months. The primary outcome measure was uncorrected binocular intermediate visual acuity (UCIVA). The secondary outcomes were binocular uncorrected distance visual acuity (UCDVA), binocular uncorrected near visual acuity (UCNVA), patient-reported outcomes measures (PROMs), spectacle independence, contrast sensitivity, photic phenomenon, enhancement surgeries and IOL exchange.ResultsA total of 113 studies were screened, of which 19, with a total of 1,530 patients, were eligible for inclusion in this review. Mean logMAR binocular UCIVA was 0.16 ± 0.01, 0.11 ± 0.06, 0.08 ± 0.07 (p = 0.41), and mean logMAR UCDVA was 0.08 ± 0.05, 0.04 ± 07, 0.04 ± 0.04 (p = 0.36), in the monofocal, enhanced monofocal, and EDOF groups, respectively. The mean spectacle independence rate was 51% ± 22.1, 55% ± 35.4 and 63.4% ± 24.6 (p = 0.05), respectively, in the monofocal, enhanced monofocal and EDOF groups. A comparable low incidence of halos and glare was observed when enhanced monofocal lenses were evaluated against traditional monofocal lenses. EDOF lenses have, however, demonstrated mixed results. The complications, IOL exchange, and excimer laser enhancement rates were low across all groups.ConclusionWhile enhanced monofocal and EDOF IOLs may provide slightly better binocular intermediate visual outcomes and higher spectacle independence compared to monofocal lenses with regards to mini-monovision and intermediate vision performance, the differences are not statistically significant. All three IOL types exhibit high patient satisfaction rates when choosing a mini-monovision approach with decreased dependence on spectacles.
Bibliometric and visualisation analyses of gastric ulcer knowledge areas and emerging trends, 2004–2024
Authors: Liu Zijian , Liu Yi , Li Yang , Sun Yuyan , Song Xiaoxiang , Chen Lu , Zhou Dan 
Published: February 2025

BackgroundGastric ulcers are a form of peptic ulcers that present as ruptures of the mucosal lining of the stomach or the proximal intestinal lining extending beyond the muscularis mucosae, and Helicobacter pylori infection is one of the main causative factors of gastric ulcers. However, the growing incidence of Helicobacter pylori drug resistance and the emergence of specialised ulcers has necessitated continued research on gastric ulcers. This study surveyed global gastric ulcer research over the past two decades with the aim of identifying the major findings and emerging trends in the field.MethodsBibliometric analysis was performed using the search terms ‘Gastric ulcer’, ‘Gastric ulcer disease’, ‘Gastrohelcoma’, and ‘Stomach ulcers’. Data were extracted from the Web of Science Core Database (WoSCC) and visualised using CiteSpace software.ResultsThe Journal of Gastroenterology had the most cited papers. The largest number of papers was from the United States. The most frequently cited keywords were ‘Helicobacter pylori’, ‘peptic ulcer’, and ‘gastric ulcer’.ConclusionThe field of gastric ulcer research is rapidly expanding, and the existing research is focused on preventing the occurrence of gastric ulcers, exploring the pathogenesis of gastric ulcers, and identifying new methods of treating gastric ulcers.
Teacher-student relationship, coping style and sports anxiety among middle school students: a situational study based in Shanghai
Authors: Qi Jiatian , Li Jingjing , Liu Bing 
Published: February 2025

ObjectiveThe present research aims to explore the relationship between coping style, teacher-student relationship, and sports anxiety among middle school students.MethodsA total of 289 Chinese middle school students from three schools in Shanghai participated in the survey.Results(1) A negative teacher-student relationship significantly affects sports anxiety, and conversely, sports anxiety significantly impacts the negative teacher-student relationship, demonstrating a strong mutual effect; (2) Both active coping style and negative coping style significantly influence sports anxiety, while sports anxiety also significantly affects active coping style among middle school students. In the two-way model of teacher-student relationship (including positive and negative dynamics) and sports anxiety, the mediating effect of coping style is not significant.Conclusion and perspectiveThis study enhances our understanding of the roles of student-teacher relationship and sports anxiety, providing a concrete sample and example for educational authorities in developed countries to identify relevant issues in the field of physical education.
“Blood is thicker than water” - experiences and perspectives of family caregivers of people living with severe mental illness at Holy Water traditional healing sites, Addis Ababa, Ethiopia
Authors: Baheretibeb Yonas , Wondimagegn Dawit , Andermann Lisa , Law Samuel 
Published: February 2025

BackgroundFamily caregivers of people with severe mental illness (SMI) are the backbone of the mental health care system in resource-limited family centered cultural setting like Ethiopia. This exploratory qualitative study examines the experiences and perspectives of family caregivers at two Ethiopian Holy Water treatment sites for people with SMI in Addis Ababa, where a collaborative project exists between traditional healers and biomedical practitioners.MethodsEleven family caregivers at two Holy Water treatment sites in Addis Ababa, Ethiopia were interviewed in 2021, using a semi-structured interview guide. The transcribed material was analyzed using qualitative thematic analysis. Inclusion criteria for study participants were over 18 years of age, capacity to give informed consent, and has a family member with mental illness for whom the family caregiver has sought help at the Holy Water treatment sites and at the collaborative Clinic.ResultsContent analysis found seven notable themes: 1. Strong sense of obligation and responsibility and ongoing provision of care; 2. Caregiving puts a serious strain on caregivers’ lives and established family roles; 3. Chronicity and persistence of illness take toll on family caregivers and networks of support; 4. Family caregivers appreciate the supportive religious setting and attendants at Holy Water treatment community; 5. Family caregivers develop a community of mutual support for each other; 6. Severe shortage and poor access to formal biomedical services and appreciation of the collaborative Clinic; 7. Burden, exhaustion, and loss of hope regarding the future.ConclusionThe study shows that families in Ethiopia face a protracted and heavy caregiver burden in their caretaking duties, often in isolation, with a severe lack of formal biological treatment and psychosocial support. Informal assistance and mutual support form part of the culturally shaped support networks, but there are on-going challenges. Innovative programs with collaborative approach show some promise. More development of community mental health services and support are urgently needed.
Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder
Authors: Shi Wenqing , Tian Ya , Yang Huiting , Guo Huirong , Wen Baohong , Liu Zijun , Zhang Yong , Han Shaoqiang , Cheng Jingliang 
Published: February 2025

BackgroundAs a crucial node of the cortico-striato-thalamo-cortical (CSTC) loop, the striatum has long been considered to be involved in the pathophysiology of obsessive-compulsive disorder (OCD). Numerous neuroimaging studies have reported functional abnormalities of the striatum in OCD. However, altered dynamic functional connectivity (DFC) patterns of striatal subregions were rarely reported in patients with OCD.MethodsWe collected resting-state functional MRI data from 97 first episode and drug-naïve OCD patients and 106 HCs matched for gender and age. Seed-based whole-brain resting-state functional connectivity (RSFC) and DFC analysis were performed for 12 striatal subregions. Between-group differences of the mean RSFC and DFC were determined using a two-sample t-test. In addition, we performed a Spearman’s correlation analysis to examine the relationship between altered RSFC and DFC and the clinical characteristics of OCD.ResultsPatients with OCD exhibited increased RSFC between the superior ventral striatum (VSs) and the calcarine (CAL), lingual gyrus (LING), cuneus (CUN), supplementary motor area (SMA), precuneus (PCUN), paracentral lobule (PCL) and superior parietal gyrus (SPG). Increased RSFC between the left dorsal caudal putamen (DCP) and LING and inferior occipital gyrus (IOG) and increased RSFC between left ventral rostral putamen (VRP) and fusiform gyrus (FFG) were also found. in OCD group. The left dorsal caudate (DC) showed increased RSFC with CAL. In addition, OCD patients shows increased RSFC between multiple striatal seeds and cerebellum. The left VSs showed decreased DFC in the OCD patients with the PCUN, SPG and superior occipital gyrus (SOG). The right DC showed decreased DFC with the medial frontal gyrus orbital part (ORBmed), superior frontal gyrus orbital part (ORBsup) and gyrus rectus (REC). OCD severity was associated with DFC values between the right DC and ORBmed (r = 0.209, p = 0.044).ConclusionOur study reveals disrupted RSFC and DFC between the striatal subregions and widespread brain regions in OCD patients. The findings highlight the role of the striatum in the neuropathology of OCD at a refined anatomical level and support the CSTC model in OCD.
Assessment of serum biomarker changes following the COVID-19 pandemic and vaccination: a cohort study in Sylhet, Bangladesh
Authors: Akther Shangida , Samiha Fairoz , Sony Sabrina Amita , Haque Mohammad Anamul , Hasnat Mohammad Abul , Islam S. M. Saiful , Ahmed Shamim , Abdullah-Al-Shoeb Mohammad 
Published: February 2025

ObjectivesCoronavirus 2019 (COVID-19) has spread throughout the world and the current COVID-19 vaccines have shown to be the most effective means of combating the COVID-19. This study focused to examine the status of serum biomarkers in individuals infected and non-infected with SARS-CoV-2, both before and after COVID-19 pandemic and vaccination.MethodsThis study comprised 133 adults aged 35 and older including both academic and non-academic personnel associated with Shahjalal University of Science and Technology in Sylhet, Bangladesh. Participants were evaluated before and after COVID-19 pandemic, as well as following two doses of vaccination. Blood samples were collected to measure different serum biomarkers, including fasting blood sugar (FBS), serum creatinine, serum alanine transaminase (ALT), total cholesterol (TC), triglyceride (TG), Low density lipoprotein-cholesterol (LDL-C), and High density lipoprotein-cholesterol (HDL-C). Statistical analysis was performed using SPSS software.ResultIn all participants, serum creatinine, FBS and TC levels significantly increased after two doses of vaccination (p = 0.022, 0.006, 0.05) compared to pre-vaccination levels. Notably, all serum biomarkers showed a significant elevation (p ≤ 0.05) in the self-reported SARS-CoV-2 infected group (n = 44). Additionally, 31% of participants were newly diagnosed with hyperglycemia after receiving the COVID-19 vaccine.ConclusionThe findings indicate that both self-reported SARS-CoV-2 infection and COVID-19 vaccination could influence different serum biomarker levels. However, further comprehensive research is necessary to discern the precise factors contributing to the alterations observed in the serum biomarker levels for future health management strategy.
Remimazolam mitigates oxidative stress response in patients undergoing one-lung ventilation
Authors: Li Shanshan , Sana Siriguleng , Wang Dan 
Published: February 2025

IntroductionThe effectiveness of remimazolam in suppressing oxidative stress, inflammatory reactions, and its lung-protective effects in patients undergoing thoracic surgery with one-lung ventilation (OLV) remains unestablished. This study aimed to investigate the protective effects of remimazolam against oxidative stress and inflammatory damage in such patients.MethodsThis randomized controlled trial evaluated 88 patients with lung tumors who underwent single-lung ventilation for thoracoscopic lobectomy under general anesthesia. Patients were randomly divided into an experimental group (R group) and a control group (Con group), with 44 patients in each group. The R group received an intravenous injection of 0.2 mg/kg of remimazolam during anesthesia induction. During anesthesia maintenance, a continuous intravenous infusion of remimazolam at a rate of 0.2 mg/kg/h was administered. The Con group received routine anesthesia. Preoperative and postoperative levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), tumor necrosis factor alpha (TNF-α), and interleukin (IL)-6 were detected. Changes in blood pressure and heart rate were recorded at four time points: upon entering the operating room (T1), immediately after tracheal intubation (T2), immediately after incision (T3), and immediately after surgery completion (T4). The postoperative awakening time, post-anesthesia care unit (PACU) stay time, and frequency of adverse reactions were also recorded.ResultsPostoperatively, the R group exhibited significantly higher levels of SOD and GSH-Px, and significantly lower levels of TNF-α and IL-6 compared to the Con group (P &lt; 0.01). At T2, the blood pressure and heart rate in R group were significantly higher than those in Con group (P &lt; 0.01), whereas no differences were found between the two groups at other time points. There were no significant differences between the two groups in postoperative awakening time, PACU stay time, or incidence of adverse reactions.DiscussionLow-dose remimazolam (0.2 mg/kg) can provide protective effects against oxidative stress and inflammatory injuries in patients undergoing OLV, without affecting awakening time or PACU time.
Description and Comparative Genomics of Algirhabdus cladophorae gen. nov., sp. nov., a Novel Aerobic Anoxygenic Phototrophic Bacterial Epibiont Associated with the Green Alga Cladophora stimpsonii
Authors: Nedashkovskaya Olga , Baldaev Sergey , Ivaschenko Alexander , Bystritskaya Evgenia , Zhukova Natalia , Eremeev Viacheslav , Kukhlevskiy Andrey , Kurilenko Valeria , Isaeva Marina 
Published: February 2025

A novel, strictly aerobic, non-motile, and pink-pigmented bacterium, designated 7Alg 153T, was isolated from the Pacific green alga Cladophora stimpsonii. Strain 7Alg 153T was able to grow at 4–32 °C in the presence of 1.5–4% NaCl and hydrolyze L-tyrosine, gelatin, aesculin, Tweens 20, 40, and 80 and urea, as well as produce catalase, oxidase, and nitrate reductase. The novel strain 7Alg 153T showed the highest similarity of 96.75% with Pseudaestuariivita rosea H15T, followed by Thalassobius litorarius MME-075T (96.60%), Thalassobius mangrovi GS-10T (96.53%), Tritonibacter litoralis SM1979T (96.45%), and Marivita cryptomonadis CL-SK44T (96.38%), indicating that it belongs to the family Roseobacteraceae, the order Rhodobacteales, the class Alphaproteobacteria, and the phylum Pseudomonadota. The respiratory ubiquinone was Q-10. The main polar lipids were phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, phosphatidylcholine, two unidentified aminolipids, and one unidentified lipid. The predominant cellular fatty acids (>5%) were C18:1 ω7c, C16:0, C18:0, and 11-methyl C18:1 ω7c. The 7Alg 153T genome is composed of a single circular chromosome of 3,786,800 bp and two circular plasmids of 53,157 bp and 37,459 bp, respectively. Pan-genome analysis showed that the 7Alg 153T genome contains 33 genus-specific clusters spanning 92 genes. The COG20-annotated singletons were more often related to signal transduction mechanisms, cell membrane biogenesis, transcription, and transport, and the metabolism of amino acids. The complete photosynthetic gene cluster (PGC) for aerobic anoxygenic photosynthesis (AAP) was found on a 53 kb plasmid. Based on the phylogenetic evidence and phenotypic and chemotaxonomic characteristics, the novel isolate represents a novel genus and species within the family Roseobacteraceae, for which the name Algirhabdus cladophorae gen. nov., sp. nov. is proposed. The type strain is 7Alg 153T (=KCTC 72606T = KMM 6494T).