bluuebunny/crossref_metadata_2025_split huggingface dataset:
Рекомендації щодо визначення кількості та складу мобільних протидиверсійних резервів під час оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил
Authors: Момот Д. 
Published: March 2023

Досвід проведення антитерористичної операції (операції об’єднаних сил) демонструє високу ефективність застосування диверсійно-розвідувальних груп (ДРГ) та незаконних збройних формувань (НЗФ) противника на початковому етапі збройного протиборства або до його початку. Враховуючи особливості міжнародних відносин та розвиток воєнно-політичної обстановки довкола нашої країни можна стверджувати,що перші операції об’єднаних сил будуть оборонними. Звідси випливає, що найбільших втрат військовим формуванням оперативного командування та шкоди державній інфраструктурі ДРГ (НЗФ) противника спроможні завдати у ході оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил.
Метою статті є розроблення рекомендацій щодо визначення кількості та складу мобільних протидиверсійних резервів у ході оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил.
Під час планування розгортання військ оперативного командування, необхідно передбачити створення достатньої кількості протидиверсійних резервів, які спроможні оперативно та своєчасно прибути до визначеного району, швидко блокувати (нейтралізувати) та знищити ДРГ (НЗФ) противника.
У ході дослідження проведено аналіз особливостей оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил. Проведений аналіз надав можливість визначити специфіку проведення розрахунків щодо створення мобільних протидиверсійних резервів у ході оперативного розгортання військ оперативного командування. Як результат, розроблені рекомендації щодо визначення кількості та складу мобільних протидиверсійних резервів у ході оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил.
Identifikasi Gambar Cadas di Situs Gua Liang Kobori Kabupaten Muna
Authors: Rasyidu Muhammad , Syahrun Syahrun , Suseno Sandy 
Published: March 2023

Muna merupakan wilayah yang banyak tersebar peninggalan arkeologi berupa gua. Gua Liang Kabori merupakan salah satu situs gambar cadas yang terdapat di kabupaten tersebut. Gua Liang Kabori terletak di Desa Liang Kabori, Kecamatan Lohia, Kabupaten Muna. Gua Liang Kobori memiliki variasi gambar cadas yang berbeda dengan situs lain di wilayah Sulawesi Tenggara. Oleh karena itu, penulis tertarik untuk melakukan penelitian disitus tersebut. Penelitian ini bertujuan untuk mengetahui bentuk dan variasi gambar cadas pada Situs Gua Liang Kabori. Metode yang digunakan dalam penelitian ini ialah pengumpulan data lapangan berupa perekaman gambar dengan cara reproduksi gambar dengan skala 1:1. Selain itu, pengelompokkan gambar menggunakan klasifikasi dan deskriptif untuk mengetahui keragaman bentuk gambar cadas pada situs Gua Liang Kabori. Dari penelitian yang dilakukan penulis, diketahui bahwa terdapat 186 motif gambar yang tersebar pada 46 panil. Gambar-gambar tersebut memiliki bentuk yang bervariasi baik dari segi motif maupun cara penggambarannya. Adapun variasi gambar tersebut terdiri dari motif figuratif; manusia, binatang dan tumbuhan. Sedangkan motif non figuratif terbagi dua yaitu geometris dan abstrak.
PENGARUH ARSITEKTUR KOLONIAL PADA RUMAH ADAT KAMALI BAADIA, KELURAHAN BAADIA, KECAMATAN MURHUM KOTA BAUBAU
Authors: Siswardin Siswardin , Kadir Ishak , Salniwati Salniwati 
Published: March 2023

The Kamali Baadia traditional house as the last palace of the Buton Sultanate, combines the traditional architectural concepts of Buton and Colonial architects, for this purpose the research aims to find out the architectural form, explain the colonial architectural forms that affect the architectural characteristics of the Kamali Baadia traditional house and to determine the significance of the influence of Colonial architecture on the architectural form of the Kamali Baadia traditional house.
This type of research is qualitative, primary and secondary data sources, literature studies, observations, interviews and documentation using morphological analysis, technology, style and significance analysis of component changes.
The architectural form of the Kamali Baadia traditional house is a stilt house with an L-shaped floor plan arranged two floors facing North. The Kamali Baadia traditional house is divided into three components, namely legs, body and roof. The influence of Dutch colonial architecture on the Kamali Baadia traditional house is the Indische Empire Style architectural style with a floor plan on the first floor, a shield roof, a two-leaf door inside motif and a two-leaf window as well as an internal motif. Significant analysis of the sign by the influence of Dutch colonial architecture Indische Empire Style architecture has not been significant.
Response to intranasal Lactococcus lactis W136 probiotic supplementation in refractory CRS is associated with modulation of non-type 2 inflammation and epithelial regeneration
Authors: Al-Romaih Saud , Harati Oumkaltoum , Mfuna Leandra Endam , Filali-Mouhim Ali , Pelletier Audrey , Renteria Flores Axel , Desrosiers Martin 
Published: March 2023

JustificationWe have previously documented that in individuals with chronic rhinosinusitis (CRS) refractory to surgery, intranasal application of live Lactococcus lactis W136, a probiotic bacterium, improves sinus-specific symptoms, SNOT-22, and mucosal aspect on endoscopy, accompanied by a reduction in sinus pathogens and an increase in protective bacteria. The present work explores the molecular mechanisms underpinning these observations using transcriptomics of the sinus mucosa.MethodEpithelial brushings collected prospectively as a sub-study of the L. lactis W136 clinical trial were used to probe epithelial responses to microbiome supplementation using a hypothesis-free bioinformatic analysis of gene expression analysis. Samples from twenty-four patients with CRS refractory to medical and surgical management were prospectively collected during a clinical trial assessing the effect of 14 days of BID nasal irrigation with 1.2 billion CFU of live L. lactis W136 probiotic bacteria (CRSwNP = 17, CRSsNP = 7). Endoscopically guided sinus brushings were collected as part of the initial study, with brushings performed immediately before and after treatment. Following RNA extraction, samples were assessed using the Illumina HumanHT-12 V4 BeadChip. Differential gene expression was calculated, and pathway enrichment analysis was performed to identify potentially implicated processes.ResultsDifferentially identified transcripts and pathways were assessed for the overall population and the clinical phenotypes of CRSwNP and CRSsNP. Patterns of response to treatment were similar across all groups, implicating pathways for the regulation of immunity and epithelial cell regulation. These resemble the patterns of improvement observed following successful treatment with endoscopic sinus surgery or azithromycin.ConclusionGene expression profiling following the application of live bacteria to the diseased sinus epithelium highlights the implication of multiple components of the inflammation-microbiome-epithelial barrier axis implicated in CRS. These effects appear to involve both epithelial restoration and modulation of innate and adaptive immunity, supporting the potential interest of targeting the sinus epithelium and the microbiome as potential CRS therapies.
Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy
Authors: Zhu Jun-Yan , Wang Xin-Chao , Huang Nan , Li Xiao-Qian , Cheng Yan , Wu Zhi-Fang , Li Yuan-Yuan , Wu Ping , Li Li , Wei Hua , Li Si-Jin , Cao Ji-Min 
Published: March 2023

BackgroundThe prognosis of patients with dilated cardiomyopathy (DCM) is poor and new indicators are urgently needed to predict lethal cardiac events. This study aimed to investigate the value of summed motion score (SMS) in predicting cardiac death of DCM patients using gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).Methods and resultsEighty-one patients with DCM who underwent 99mTc-MIBI gated SPECT MPI were retrospectively enrolled and were divided into cardiac death and survivor groups. The functional parameters of left ventricle including SMS were measured using quantitative gated SPECT software. During the follow-up period of 44 (25, 54) months, 14 (17.28%) cardiac deaths were observed. Compared with the survivor group, SMS was significantly higher in the cardiac death group. Multivariate cox regression analysis showed that SMS was an independent predictor for cardiac death (HR 1.34, 95% CI 1.02–1.77, P = 0.034). SMS also provided incremental prognostic value over other variables in the multivariate model as determined by likelihood ratio global chi-squared test. In the Kaplan-Meier survival analysis, the event-free survival rate was significantly lower in the high-SMS (HSMS) group than the low-SMS (LSMS) (log-rank P &lt; 0.001). Furthermore, the area under curve (AUC) of SMS was larger than that of LVEF at the 12th month of follow-up (0.85 vs. 0.80, P = 0.045).ConclusionSMS is an independent predictor of cardiac death in DCM patients and provides incremental prognostic value. SMS might have higher predictive value than LVEF for early cardiac death.
Real-life and real-time hearing aid experiences: Insights from self-initiated ecological momentary assessments and natural language analysis
Authors: Vercammen Charlotte , Oosthuizen Ilze , Manchaiah Vinaya , Ratinaud Pierre , Launer Stefan , Swanepoel De Wet 
Published: March 2023

IntroductionSmartphone technology can provide an effective means to bring real-life and (near-)real-time feedback from hearing aid wearers into the clinic. Ecological Momentary Assessment (EMA) encourages listeners to report on their experiences during or shortly after they take place in order to minimize recall bias, e.g., guided by surveys in a mobile application. Allowing listeners to describe experiences in their own words, further, ensures that answers are independent of predefined jargon or of how survey questions are formulated. Through these means, one can obtain ecologically valid sets of data, for instance during a hearing aid trial, which can support clinicians to assess the needs of their clients, provide directions for fine-tuning, and counselling. At a larger scale, such datasets would facilitate training of machine learning algorithms that could help hearing technology to anticipate user needs.MethodsIn this retrospective, exploratory analysis of a clinical data set, we performed a cluster analysis on 8,793 open-text statements, which were collected through self-initiated EMAs, provided by 2,301 hearing aid wearers as part of their hearing care. Our aim was to explore how listeners describe their daily life experiences with hearing technology in (near-)real-time, in their own words, by identifying emerging themes in the reports. We also explored whether identified themes correlated with the nature of the experiences, i.e., self-reported satisfaction ratings indicating a positive or negative experience.ResultsResults showed that close to 60% of listeners' reports related to speech intelligibility in challenging situations and sound quality dimensions, and tended to be valued as positive experiences. In comparison, close to 40% of reports related to hearing aid management, and tended to be valued as negative experiences.DiscussionThis first report of open-text statements, collected through self-initiated EMAs as part of clinical practice, shows that, while EMA can come with a participant burden, at least a subsample of motivated hearing aid wearers could use these novel tools to provide feedback to inform more responsive, personalized, and family-centered hearing care.
Cortisol and periodontitis: Prospective observational and Mendelian randomization studies
Authors: Baumeister Sebastian-Edgar , Reckelkamm Stefan Lars , Grabe Hans-Jörgen , Nauck Matthias , Klinger-König Johanna , Völzke Henry , Kocher Thomas , Friedrich Nele , Holtfreter Birte 
Published: March 2023

PurposeCortisol has obesogenic, hyperglycemic and immunomodulating effects. Preclinical and observational research suggested that it is associated with periodontitis but the evidence for potential causality in humans is sparse. We triangulated results from prospective observational and Mendelian randomization (MR) analyses to further explore this.MethodsUsing pooled data from 3,388 participants of two population cohort studies embedded in the Study of Health in Pomerania (SHIP) project, we associated serum cortisol levels with periodontal outcomes measured after a median follow-up time of 6.9 years, adjusting for confounding and selection bias using propensity score weighting and multiple imputation. We further examined the effect of genetically proxied plasma morning cortisol levels on periodontitis using two-sample MR of 17,353 cases and 28,210 controls.ResultsIn SHIP, we found that cortisol levels were positively associated with follow-up levels of mean clinical attachment level (CAL), deep interdental CAL and bleeding on probing but were unrelated to mean probing pocket depth and deep periodontal pockets. In MR analysis, cortisol was not associated with periodontitis.ConclusionThe observational study revealed a prospective association of spot cortisol with makers of periodontitis. Contrary to observational studies, genetically instrumented, long-term cortisol was unrelated to periodontitis. Our results find no univocal evidence that cortisol plays a role in periodontitis pathology, casting doubt on cortisol-related pathways.
Clinical correlates and metabolic indicators of elevated fasting glucose in overweight/obese Chinese Han patients with first-episode and drug-naive major depressive disorder
Authors: Gao Wenqi , Deng Zhifang , Cai Xiaonan , Zhang Dan , Xiao Han , Zhang Xiangyang 
Published: March 2023

BackgroundOverweight/obese major depressive disorder (MDD) patients have a high probability of developing glucose metabolism disorders; however, the results are inconsistent due to the confounding variables involved in the studies. The purpose of this study was to explore the prevalence and risk factors for elevated fasting glucose in Chinese Han patients with overweight/obese first-episode and drug naïve (FEDN) MDD.MethodsThe study used a cross-sectional design and recruited 1718 FEDN MDD patients between the ages of 18 and 60 years. Socio-demographic information, anthropometric data, and biochemical parameters were collected. The 17-item Hamilton Assessment Scale for Depression (HAMD), the 14-item Hamilton Anxiety Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) positive subscale were used to assess symptoms of all patients.ResultsMDD patients with elevated fasting glucose had higher TSH, TPOAb, TC, TG, LDL-C, systolic and diastolic blood pressure levels than those with normal fasting glucose. Logistic regression analysis showed that age, TSH, TgAb, TPOA, and TG were related factors for elevated fasting glucose, while TSH and combination all these five parameters had the potential to differentiate between patients with elevated fasting glucose and those with normal fasting glucose. Multifactorial regression analysis showed that TSH, TG, and LDL-C were independently associated with elevated fasting glucose.ConclusionOur findings suggest a high prevalence of elevated fasting glucose in overweight/obese FEDN MDD patients. Several clinically relevant factors and metabolic parameters are associated with elevated fasting glucose in overweight/obese FEDN MDD patients.LimitationDue to the cross-sectional design, no causal relationship could be derived.
Transcriptome landscape comparison of periodontium in developmental and renewal stages
Authors: Deng Yuwei , Luo Nan , Xie Ming , He Ling , Jiang Ruixue , Hu Nan , Wen Jin , Jiang Xinquan 
Published: March 2023

ObjectivesPeriodontium regeneration remains a significant challenge in clinics and research, and it is essential to understand the stage-specific biological process in situ. However, differing findings have been reported, and the mechanism has yet to be elucidated. The periodontium of adult mice molars is considered to be stable remodeling tissue. At the same time, the continuously growing incisors and the developing dental follicle (DF) of postnatal mice highly represent fast remodeling tissue. In this study, we attempted to explore different clues of temporal and spatial comparisons to provide improved references for periodontal regeneration.MethodsPeriodontal tissues from the developing periodontium (DeP) of postnatal mice, and continuously growing periodontium (CgP) and stable remodeling periodontium (ReP) of adult mice were isolated and compared using RNA sequencing. Based on the Dep and CgP separately compared with the ReP, differentially expressed genes and signaling pathways were analyzed using GO, KEGG databases, and Ingenuity Pathway Analysis (IPA). The results and validation were obtained by immunofluorescence staining and RT-PCR assays. Data were expressed as means ± standard deviation (SD) and analyzed by GraphPad Prism 8 software package, and one-way ANOVA was used to test multiple groups.ResultsPrincipal component analysis showed that the three groups of periodontal tissue were successfully isolated and had distinct expression profiles. A total of 792 and 612 DEGs were identified in the DeP and CgP groups compared with the ReP. Upregulated DEGs in the DeP were closely related to developmental processes, while the CgP showed significantly enhanced cellular energy metabolism. The DeP and CgP showed a common downregulation of the immune response, with activation, migration, and recruitment of immune cells. IPA and further validation jointly suggested that the MyD88/p38 MAPK pathway played an essential regulatory role in periodontium remodeling.ConclusionTissue development, energy metabolism, and immune response were critical regulatory processes during periodontal remodeling. Developmental and adult stages of periodontal remodeling showed different expression patterns. These results contribute to a deeper understanding of periodontal development and remodeling and may provide references for periodontal regeneration.
Irrigation suitability and health risk assessment of groundwater resources in the Firozabad industrial area of north-central India: An integrated indexical, statistical, and geospatial approach
Authors: Saraswat Anuj , Nath Triyugi , Omeka Michael E. , Unigwe Chinanu O. , Anyanwu Ifeanyi E. , Ugar Samuel I. , Latare Ashish , Raza Md Basit , Behera Biswaranjan , Adhikary Partha P. , Scopa Antonio , AbdelRahman Mohamed A. E. 
Published: March 2023

The recent global upsurge in anthropogenic activities has resulted in a decline in the quality of water. This by extension has resulted in increased ubiquity of water pollution in terms of sources. The application of traditional water quality assessment methods usually involves the use of conventional water quality parameters and guideline values. This may be associated with bias and errors during the computation of various sub-indices. Hence, to overcome this limitation, it is critical to have a visual appraisal of the water quality in terms of source and human health risks exposure for sustainable water resource management and informed decision-making. Therefore, the present study has integrated multiple water quality assessment indices, spatio-temporal, and statistical models to assess the suitability of fifty groundwater samples (n = 50) within the Firozabad industrial area for irrigation and drinking; as well as the likely health risks from oral intake and dermal contact by inhabitants. Electrical conductivity (mean = 1,576.6 μs/cm), total hardness (mean = 230.9 mg/L), dissolved sodium (mean = 305.1 mg/L) chloride (mean = 306.1 mg/L) and fluoride (mean = 1.52 mg/L) occurred in the water at concentrations above the recommended standards; attributed influxes from agricultural and industrial wastewater. The pollution index of groundwater and water quality index revealed that 100% of the groundwater samples are extremely polluted; this was also supported by the joint multivariate statistical analyses. The majority of the irrigational water quality indices (sodium adsorption ratio, Kelly’s Ratio, permeability index, percent sodium) revealed that the long-term use of the groundwater for irrigation in the area will result in reduced crop yield unless remedial measures are put in place. Higher Hazard index (HI &gt; 1) for nitrate and fluoride ingestion was recorded in water for the children population compared to adult; an indication that the children population is more predisposed to health risks from the oral intake of water. Generally, risk levels from ingestion appear to increase in the western and north-eastern parts of the study area. From the findings of this study, it is highly recommended that adequate agricultural practices, land use, and water treatment regulatory strategies be put in place for water quality sustainability for enhanced agricultural production and human health protection.
Adrenergic receptor signaling regulates the CD40-receptor mediated anti-tumor immunity
Authors: Singh Akansha , Ranjan Ashish 
Published: March 2023

IntroductionAnti-CD40 agonistic antibody (αCD40), an activator of dendritic cells (DC) can enhance antigen presentation and activate cytotoxic T-cells against poorly immunogenic tumors. However, cancer immunotherapy trials also suggest that αCD40 is only moderately effective in patients, falling short of achieving clinical success. Identifying factors that decrease αCD40 immune-stimulating effects can aid the translation of this agent to clinical reality.Method/ResultsHere, we reveal that β-adrenergic signaling on DCs directly interferes with αCD40 efficacy in immunologically cold head and neck tumor model. We discovered that β-2 adrenergic receptor (β2AR) activation rewires CD40 signaling in DCs by directly inhibiting the phosphorylation of IκBα and indirectly by upregulating levels of phosphorylated-cAMP response element-binding protein (pCREB). Importantly, the addition of propranolol, a pan β-Blocker reprograms the CD40 pathways, inducing superior tumor regressions, increased infiltration of cytotoxic T-cells, and a reduced burden of regulatory T-cells in tumors compared to monotherapy.ConclusionOur study highlights an important mechanistic link between stress-induced β2AR signaling and reduced αCD40 efficacy in cold tumors, providing a new combinatorial approach to improve clinical outcomes in patients.