bluuebunny/crossref_metadata_2025_split huggingface dataset:
The injections of mitochondrial fusion promoter M1 during proestrus disrupt the progesterone secretion and the estrous cycle in the mouse
Authors: Budi Yovita Permata , Hsu Meng-Chieh , Lin Yi-Chun , Lee Yue-Jia , Chiu Hsin-Yi , Chiu Chih-Hsien , Jiang Yi-Fan 
Published: February 2023

AbstractAfter ovulation, the mitochondrial enzyme CYP11A1 cleavage the cholesterol into pregnenolone for progesterone synthesis, suggesting that mitochondrial dynamics play a vital role in the female reproductive system. The changes in the mitochondria dynamics throughout the ovarian cycle have been reported in literature, but the correlation to its role in the ovarian cycle remains unclear. In this study, mitochondrial fusion promotor, M1, was used to study the impact of mitochondria dynamics in the female reproductive system. Our results showed that M1 treatment in mice can lead to the disruptions of estrous cycles in vagina smears. The decrease in serum LH was recorded in the animal. And the inhibitions of progesterone secretion and ovulations were observed in ovarian culture. Although no significant changes in mitochondrial networks were observed in the ovaries, significant up-regulation of mitochondrial respiratory complexes was revealed in M1 treatments through transcriptomic analysis. In contrast to the estrogen and steroid biosynthesis up-regulated in M1, the molecules of extracellular matrix, remodeling enzymes, and adhesion signalings were decreased. Collectively, our study provides novel targets to regulate the ovarian cycles through the mitochondria. However, more studies are still necessary to provide the functional connections between mitochondria and the female reproductive systems.
Prevalence and trends of perioperative major adverse cardiovascular and cerebrovascular events during cancer surgeries
Authors: Ramamoorthy Venkataraghavan , Chan Kelvin , Appunni Sandeep , Zhang Zhenwei , Ahmed Md Ashfaq , McGranaghan Peter , Saxena Anshul , Rubens Muni 
Published: February 2023

AbstractMajor adverse cardiovascular and cerebrovascular events (MACCE) is an important cause of morbidity and mortality during perioperative period. In this study, we looked for national trends in perioperative MACCE and its components as well as cancer types associated with high rates of perioperative MACCE during major cancer surgeries. This study was a retrospective analysis of the National Inpatient Sample, 2005–2014. Hospitalizations for surgeries of prostate, bladder, esophagus, pancreas, lung, liver, colorectal, and breast among patients 40 years and greater were included in the analysis. MACCE was defined as a composite measure that included in-hospital all-cause mortality, acute myocardial infarction (AMI), and ischemic stroke. A total of 2,854,810 hospitalizations for major surgeries were included in this study. Of these, 67,316 (2.4%) had perioperative MACCE. Trends of perioperative MACCE showed that it decreased significantly for AMI, death and any MACCE, while stroke did not significantly change during the study period. Logistic regression analysis for perioperative MACCE by cancer types showed that surgeries for esophagus, pancreas, lung, liver, and colorectal cancers had significantly greater odds for perioperative MACCE. The surgeries identified to have greater risks for MACCE in this study could be risk stratified for better informed decision-making and management.
Genome-wide identification and characterization of parthenocarpic fruit set-related gene homologs in cucumber (Cucumis sativus L.)
Authors: Kaur Harleen , Manchanda Pooja , Kumar Pankaj , Dhall Rajinder Kumar , Chhuneja Parveen , Weng Yiqun 
Published: February 2023

AbstractCucumber (Cucumis sativus L.), a major horticultural crop, in the family Cucurbitaceae is grown and consumed globally. Parthenocarpy is an ideal trait for many fruit and vegetables which produces seedless fruit desired by consumers. The seedlessness occurs when fruit develops without fertilization which can be either natural or induced. So far, a limited number of genes regulating parthenocarpic fruit set have been reported in several fruit or vegetable crops, most of which are involved in hormone biosynthesis or signalling. Although parthenocarpic cucumber has been widely used in commercial production for a long time; its genetic basis is not well understood. In this study, we retrieved thirty five parthenocarpy fruit-set related genes (PRGs) from bibliomic data in various plants. Thirty-five PRG homologs were identified in the cucumber genome via homology-based search. An in silico analysis was performed on phylogenetic tree, exon–intron structure, cis-regulatory elements in the promoter region, and conserved domains of their deduced proteins, which provided insights into the genetic make-up of parthenocarpy-related genes in cucumber. Simple sequence repeat (SSR) sequences were mined in these PRGs, and 31 SSR markers were designed. SSR genotyping identified three SSRs in two polymorphic genes. Quantitative real-time PCR of selected genes was conducted in five cucumber lines with varying degrees of parthenocarpic fruit set capacities, which revealed possible association of their expression with parthenocarpy. The results revealed that homologs CsWD40 and CsPIN-4 could be considered potential genes for determination of parthenocarpy as these genes showed parental polymorphism and differential gene expression in case of parthenocarpic and non-parthenocarpic parents.
Solubilized LiNO3by the cationic size effect of CsF for lithium metal anode protection and dendrite formation prevention in carbonate electrolyte
Authors: Zhao Jing , Wan Zhengwei , Zeng Xiaomin , Tian Miaomiao , Wang Kun , Chen Xinyu , Ling Min , Ni Wenbin , Liang Chengdu 
Published: February 2023

CsF solubilized LiNO3 to optimize solvated shell of Li+ in carbonate electrolyte. LiF-rich SEI was generated to prevent severe side reactions of Li metal. Cs+ can inhibit lithium dendrite formation by self-healing electrostatic shield mechanism.
“Please Don't Assess Him to Destruction”: The R.A.I.S.E. Assessment Framework for Primary Progressive Aphasia
Authors: Gallée Jeanne , Cartwright Jade , Volkmer Anna , Whitworth Anne , Hersh Deborah 
Published: February 2023

Purpose:
Speech-language pathologists (SLPs) assess people with primary progressive aphasia (PPA) through measurements of speech, language, communication, and well-being, with the aims of identifying challenges and strengths, monitoring change, and informing treatment directions and supports. The purpose of this clinical focus article is to highlight the necessity for person-centered assessment specific to PPA and to conceptualize a framework that acknowledges the multifaceted nature of assessment for this population. In this framework, the unique challenges posed by a diagnosis of PPA are addressed with the aim to provide practical guidance for clinicians and to support reflection on current practices.

Method:
In clinical and research practice, assessment of people with PPA requires an ever-evolving approach that is centered on the client. In this clinical focus article, a discussion-based consensus process was used to synthesize authentic longitudinal experiences of people with PPA to explore assessment approaches, tools, and philosophies.

Results:
This analysis of person-centered assessment identifies seven essential components of assessment in PPA that set the foundation for the five steps of the R.A.I.S.E. Assessment framework. These components each contribute to a clear definition of assessment that reveals clients' competencies with a strengths-based focus; prioritizes the reciprocity of benefits; promotes dynamic assessment; and recognizes the complexity, evolution of assessment over time, and advocacy.

Conclusions:
This clinical focus article takes a novel look at assessment in PPA by stepping away from assessment practices that focus on revealing deficits and decline and, instead, provides practical recommendations through the conceptualization of a PPA-specific assessment framework. The R.A.I.S.E. Assessment framework is grounded in principles of uplifting clients through person-centered assessment, keeps pace with best practice in PPA intervention, and contributes to a supportive experience for clients and families in the face of a progressive diagnosis over time.
How a Power Differential Between Clinicians and Researchers Contributes to the Research-to-Practice Gap
Authors: Douglas Natalie , Hinckley Jacqueline , Grandbois Kate , Schliep Megan , Wonkka Amy , Oshita Jennifer , Feuerstein Julie 
Published: February 2023

Purpose:
The purpose of this article is to contend that there is a power differential between researchers and clinicians where researchers are the primary creators of knowledge and clinicians are the primary consumers of knowledge. Rooted in a sociological model illustrating interacting levels of power at macro-, meso-, and microlevels, we argue that authentic research–practice partnerships and clinician–researcher collaborations can mitigate this power differential.

Conclusions:
Clinicians and researchers in our field have vastly different responsibilities and priorities that impact our ability to work collaboratively to solve the most pressing problems for the clients we serve. Although some current research practices may reinforce a power differential causing clinicians to feel less than and to only consume knowledge, there are examples of successful collaborations where this power differential is mitigated. These examples can contribute meaningfully to the dialogue on research–practice partnerships, with the goal of improving outcomes for the clients we serve.
A Comprehensive Analysis of Speech Disfluencies in Autistic Young Adults and Control Young Adults: Group Differences in Typical, Stuttering-Like, and Atypical Disfluencies
Authors: Pirinen Veera , Loukusa Soile , Dindar Katja , Mäkinen Leena , Hurtig Tuula , Jussila Katja , Mattila Marja-Leena , Eggers Kurt 
Published: February 2023

Purpose:
The purpose of this study was to examine the nature of speech disfluencies in autistic young adults and controls by using a wide-range disfluency classification of typical disfluencies (TD; i.e., filled pauses, revisions, abandoned utterances, and multisyllable word and phrase repetitions), stuttering-like disfluencies (SLD; i.e., sound and syllable repetitions, monosyllable word repetitions, prolongations, blocks, and broken words), and atypical disfluencies (AD; i.e., word-final prolongations and repetitions and atypical insertions).

Method:
Thirty-two autistic young adults and 35 controls completed a narrative telling task based on socially complex events. Frequencies of total disfluencies, TD, SLD, AD and stuttering severity were compared between groups.

Results:
The overall frequency of disfluencies was significantly higher in the autistic group and significant between-group differences were found for all disfluency categories. The autistic group produced significantly more revisions, filled pauses, and abandoned utterances, and each subtype of SLD and AD than the control group. In total, approximately every fourth autistic participants scored at least a very mild severity of stuttering, and every fifth produced more than three SLD per 100 syllables.

Conclusions:
Disfluent speech can be challenging for effective communication. This study revealed that the speech of autistic young adults was highly more disfluent than that of the controls. The findings provide information on speech disfluency characteristics in autistic young adults and highlight the importance of evaluating speech disfluency with a wide-range disfluency classification in autistic persons in order to understand their role in overall communication. The results of this study offer tools for SLPs to evaluate and understand the nature of disfluencies in autistic persons.
Do Second Graders Adjust Their Language by Discourse Context?
Authors: Cho Minkyung , Kim Young-Suk Grace 
Published: February 2023

Purpose:
Children's ability to adjust one's language according to discourse context is important for success in academic settings. This study examined whether second graders vary in linguistic and discourse features depending on discourse contexts, that is, when describing pictures in contextualized (describing the picture to an examiner while looking at it together) and decontextualized (pretending to describe the picture to a friend while sitting in front of the examiner) conditions.

Method:

A total of 330 English-speaking second graders in the United States (
M
age
= 7.33 years; 53% boys; 55% Caucasian children, 35% African American children) described three pictures in contextualized and decontextualized conditions. Children's picture descriptions were transcribed verbatim and coded for linguistic (e.g., elaborated noun phrase) and discourse (e.g., proper character introduction, degree of decontextualization) features.

Results:
Type–token ratio was higher in the contextualized condition than in the decontextualized condition, whereas certain types of elaborated noun phrases (e.g., simple descriptive noun phrase, noun phrase with postmodification), coordinating conjunctions, and nonclauses occurred more frequently in the decontextualized condition, controlling for total productivity and student demographics. The proportion of proper character introduction was higher in the decontextualized condition, whereas higher degrees of decontextualization and complex perspective-taking were found in the contextualized condition.

Conclusion:
Various linguistic and discourse cues illustrated the extent to which primary grade students employ their discourse knowledge when producing oral language.
Periodontal disease in pregnancy: A comparative prospective
study
Authors: Ortmann Nora , Möllers Mareike , Braun Janina , Sourouni Marina , Willy Daniela , Köster Helen Ann , Klockenbusch Walter , Schmitz Ralf , Oelmeier Kathrin 
Published: February 2023

Abstract
Introduction Periodontal disease affects many pregnant women and may be
associated with adverse pregnancy outcomes. The object of this study was to
evaluate women’s level of knowledge about this condition in pregnancy.
We compared level of knowledge, participation in medical screening, and
periodontal health status in pregnant women and nonpregnant controls.
Material and Methods This study included 141 pregnant and 141 nonpregnant
women, examined by one examiner at the Department of Gynecology and Obstetrics
of the University Hospital Muenster, Germany. With reference to periodontal
health status, the Periodontal Screening Index was used and a questionnaire was
designed to represent the level of knowledge and predisposing factors.
Results Pregnant women showed a strong tendency towards higher Periodontal
Screening Indices than the nonpregnant controls (P=0.058). A strong
positive correlation between participation in screenings and a lower Periodontal
Screening Index was measured, but no direct relation between knowledge and
periodontal health was detected. However, a better level of knowledge correlated
noticeably with participation in screening programs. Educational attainment was
found to be a main factor correlated with periodontal health and further factors
such as medical screening and smoking habits. A great number of women felt they
were not sufficiently informed about oral health aspects in pregnancy.
Conclusions As participation in screenings was a main item that positively
correlated with healthier periodontal status, it had to be a focused element.
The possible positive influence of knowledge regarding the participation in
screening programs showed not only the need to spread awareness but also the
need for proper education.
Verlauf eines frühgeborenen Geminus nach totalem
Muttermundsverschluss bei Spontanabort des ersten Geminus in der 19+1
Schwangerschaftswoche – Fallbericht und
Literaturübersicht
Authors: Kögel Matthias , Werner Matthias , Knuf Markus , Hitschold Thomas 
Published: February 2023

ZusammenfassungWir berichten über den geburtshilflichen und neonatologischen Verlauf
einer 34-jährigen Geminigravida, die sich erstmalig in der 16+1
Schwangerschaftswoche (SSW) in unserer Klinik mit vorzeitigem Blasensprung
vorstellte. Bei vitalen und zeitgerecht entwickelten Gemini mit Anhydramnion des
führenden Zwillings erfolgte die stationäre Überwachung
unter intravenöser antiinfektiver Therapie. Nach verhaltenem Abort des
ersten Geminus in der 19+1 SSW wurde eine operative Intervention mit
assistierter Entbindung des ersten Geminus unter Belassung der Plazenta in situ
mit anschließendem notfallmäßigem totalen
Muttermundverschluss durchgeführt. Die verbliebene Einzelschwangerschaft
konnte bis zur 24. SSW fortgeführt werden. Dann erfolgte bei
unaufhaltsamer Wehentätigkeit, vorzeitigem Blasensprung und steigenden
Entzündungszeichen im Labor der Mutter die eilige Sectio. Postnatal
zeigte das Frühgeborene einen für das Gestationsalter insgesamt
erfreulichen Verlauf, so dass in zukünftigen ähnlichen
Fällen die Option der operativen Maßnahmen mit
berücksichtigt werden sollte.
Hemostatic spray (TC-325) vs. standard endoscopic therapy for non-variceal gastrointestinal bleeding: A meta-analysis of randomized controlled trials
Authors: Deliwala Smit S. , Chandan Saurabh , Mohan Babu P. , Khan Shahab , Reddy Nitin , Ramai Daryl , Bapaye Jay A. , Dahiya Dushyant Singh , Kassab Lena L. , Facciorusso Antonio , Chawla Saurabh , Adler Douglas 
Published: February 2023

Abstract
Background and study aims Hemospray (TC-325) is a mineral powder with adsorptive properties designed for use in various gastrointestinal bleeding (GIB) scenarios. We conducted a systematic review & meta-analysis of randomized controlled trials (RCTs) comparing TC-325 to standard endoscopic therapy (SET) for non-variceal GIB (NVGIB).
Methods Multiple databases were searched through October 2022. Meta-analysis was performed using a random-effects model to determine pooled relative risk (RR) and proportions with 95 % confidence intervals (CI) for primary hemostasis, hemostasis failure, 30-day rebleeding, length of stay (LOS), and need for rescue interventions. Heterogeneity was assessed using I2%.
Results Five RCTs with 362 patients (TC-325 178, SET 184) – 123 females and 239 males with a mean age 65 ± 16 years). The most common etiologies were peptic ulcer disease (48 %), malignancies (35 %), and others (17 %). Bleeding was characterized as Forrest IA (7 %), IB (73 %), IIA (3 %), and IIB (1 %). SET included epinephrine injection, electrocautery, hemoclips, or a combination. No statistical difference in primary hemostasis between TC-325 compared to SET, RR 1.09 (CI 0.95–1.25; I2 43), P = 0.2, including patients with oozing/spurting hemorrhage, RR 1.13 (CI 0.98–1.3; I2 35), P = 0.08. Failure to achieve hemostasis was higher in SET compared to TC-325, RR 0.30 (CI 0.12–0.77, I2 0), P = 0.01, including patients with oozing/spurting hemorrhage, RR 0.24 (CI 0.09 – 0.63, I2 0), P = 0.004. We found no difference between the two interventions in terms of rebleeding, RR 1.13 (CI 0.62–2.07, I2 26), P = 0.8 and LOS, standardized mean difference (SMD) 0.27 (CI, –0.20–0.74; I2 62), P = 0.3. Finally, pooled rate of rescue interventions (angiography) was statistically higher in SET compared to TC-325, RR 0.68 (CI 0.5–0.94; I2 0), P = 0.02.
Conclusions Our analysis shows that for acute NV GIB, including oozing/spurting hemorrhage, TC-325 does not result in higher rates of primary hemostasis compared to SET. However, lower rates of failures were seen with TC-325 than SET. In addition, there was no difference in the two modalities when comparing rates of rebleeding and LOS.
Point Prevalence Study (PPS) of Antibiotic Usage and Bacterial Culture Rate (BCR) among Secondary Care Hospitals of Small Cities in Central India: Consolidating Indian Evidence
Authors: Kumar Shweta , Shukla Pankaj , Goel Pramod , Mishra Vivek , Gupta Ayush , Karuna Tadepalli , Srivastava Rakesh , Gupta Amit , Baharani Deepak , Pansey Parijat , Chandiwal Sunil , Shrivastava Sandeep , Gupta Ankur , Rajpoot Shailendra Singh , Biswal DebaDulal , Ansari Mehrunnisa , Walia Kamini , Khadanga Sagar 
Published: February 2023

Abstract
Objective Indian hospitals (especially government-run public sector hospitals) have a nonexistent antimicrobial stewardship program (AMSP). After successfully initiating AMSPs in tertiary care hospitals of India, the Indian Council of Medical Research envisages implementing AMSP in secondary care hospitals. This study is about the baseline data on antibiotic consumption in secondary care hospitals.
Materials and Methods It was a prospective longitudinal observational chart review type of study. Baseline data on antibiotic consumption was captured by a 24-hour point prevalence study of antibiotic usage and bacterial culture rate. The prescribed antibiotics were classified according to the World Health Organization (WHO) Access, Watch, and Reserve classification. All data were collated in Microsoft Excel and summarized as percentages.
Results Out of the 864 patients surveyed, overall antibiotic usage was 78.9% (71.5% in low-priority areas vs. 92.2% in high-priority areas). Most of the antibiotic usage was empirical with an extremely low bacterial culture rate (21.9%). Out of the prescribed drugs, 53.1% were from the WHO watch category and 5.5% from the reserve category.
Conclusion Even after 5 years of the launch of the national action plan on AMR (NAP-AMR) of India, AMSP is still non-existent in small- and medium-level hospitals in urban cities. The importance of trained microbiologists in the health care system is identified as a fulcrum in combating antimicrobial resistance (AMR); however, their absence in government-run district hospitals is a matter of grave concern and needs to be addressed sooner than later.
Acanthus ilicifolius Methanolic Extract for Oral Candidiasis Treatment through Tongue Epithelial STAT3 and Cell Death Evaluation
Authors: Revianti Syamsulina , Andriani Dwi , Pargaputri Agni Febrina , Hartono Mardiyanto Riski 
Published: February 2023

Abstract
Objectives This study aimed to evaluate the effects of topical application of Acanthus ilicifolius methanolic extract on signal transducer and activator of transcription 3 (STAT3) expression and tongue epithelial cell death caused by oral candidiasis under immunosuppressive conditions.
Materials and Methods To obtain the oral candidiasis model, 20 healthy male Rattus norvegicus (Wistar) rats were administered oral dexamethasone and tetracycline for 14 days and oral candidiasis was induced with Candida albicans (ATCC-10231) 1 McFarland. They were then randomized into four groups—immunosuppression (K-), oral candidiasis (K + ), nystatin treatment (P1), and 20% A. ilicifolius methanolic extract treatment (P2) and were treated for 14 days. Histological analyses of cell death and candida invasion and immunohistochemical analysis of STAT3 in epithelial cells were performed.
Statistical Analysis Epithelial cell death data were analyzed using one-way analysis of variance (ANOVA) and the post hoc Games–Howell test (p < 0.05) and STAT3 expression with one-way ANOVA and the post hoc least significant difference test (p < 0.05).
Results Cell death was significantly different between K- and K+ and between K+ and P1 and P2 (p < 0.05); there were no significant differences between K- and P1 and P2 and between P1 and P2 (p > 0.05). STAT3 expression was significantly different between K- and P1 and P2 and between K+ and P1 and P2 (p < 0.05), but there were no significant differences between K+ and K- and between P1 and P2 (p > 0.05).
Conclusion Topical administration of A. ilicifolius methanol extract increased STAT3 expression and decreased tongue epithelial cell death caused by oral candidiasis.