bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness and diagnosis for intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in neonatal (NICU) and pediatric intensive care units (PICU) – a follow-up multicenter survey
Authors: Wiegandt Paul , Jack Thomas , von Gise Alexander , Seidemann Kathrin , Boehne Martin , Koeditz Harald , Beerbaum Philipp , Sasse Michael , Kaussen Torsten 
Published: February 2023

Abstract
Background
Constantly elevated intra-abdominal pressure (IAH) can lead to abdominal compartment syndrome (ACS), which is associated with organ dysfunction and even multiorgan failure. Our 2010 survey revealed an inconsistent acceptance of definitions and guidelines among pediatric intensivists regarding the diagnosis and treatment of IAH and ACS in Germany. This is the first survey to assess the impact of the updated guidelines on neonatal/pediatric intensive care units (NICU/PICU) in German-speaking countries after WSACS published those in 2013.

Methods
We conducted a follow-up survey and sent 473 questionnaires to all 328 German-speaking pediatric hospitals. We compared our findings regarding awareness, diagnostics and therapy of IAH and ACS with the results of our 2010 survey.

Results
The response rate was 48% (n = 156). The majority of respondents was from Germany (86%) and working in PICUs with mostly neonatal patients (53%).
The number of participants who stated that IAH and ACS play a role in their clinical practice rose from 44% in 2010 to 56% in 2016. Similar to the 2010 investigations, only a few neonatal/pediatric intensivists knew the correct WSACS definition of an IAH (4% vs 6%). Different from the previous study, the number of participants who correctly defined an ACS increased from 18 to 58% (p < 0,001). The number of respondents measuring intra-abdominal pressure (IAP) increased from 20 to 43% (p < 0,001). Decompressive laparotomies (DLs) were performed more frequently than in 2010 (36% vs. 19%, p < 0,001), and the reported survival rate was higher when a DL was used (85% ± 17% vs. 40 ± 34%).

Conclusions
Our follow-up survey of neonatal/pediatric intensivists showed an improvement in the awareness and knowledge of valid definitions of ACS. Moreover, there has been an increase in the number of physicians measuring IAP in patients. However, a significant number has still never diagnosed IAH/ACS, and more than half of the respondents have never measured IAP. This reinforces the suspicion that IAH and ACS are only slowly coming into the focus of neonatal/pediatric intensivists in German-speaking pediatric hospitals. The goal should be to raise awareness of IAH and ACS through education and training and to establish diagnostic algorithms, especially for pediatric patients.
The increased survival rate after conducting a prompt DL consolidates the impression that the probability of survival can be increased by timely surgical decompression in the case of full-blown ACS.
A population-based study to assess two convolutional neural networks for dental age estimation
Authors: Wang Jian , Dou Jiawei , Han Jiaxuan , Li Guoqiang , Tao Jiang 
Published: February 2023

Abstract
Background
Dental age (DA) estimation using two convolutional neural networks (CNNs), VGG16 and ResNet101, remains unexplored. In this study, we aimed to investigate the possibility of using artificial intelligence-based methods in an eastern Chinese population.

Methods
A total of 9586 orthopantomograms (OPGs) (4054 boys and 5532 girls) of the Chinese Han population aged from 6 to 20 years were collected. DAs were automatically calculated using the two CNN model strategies. Accuracy, recall, precision, and F1 score of the models were used to evaluate VGG16 and ResNet101 for age estimation. An age threshold was also employed to evaluate the two CNN models.

Results
The VGG16 network outperformed the ResNet101 network in terms of prediction performance. However, the model effect of VGG16 was less favorable than that in other age ranges in the 15–17 age group. The VGG16 network model prediction results for the younger age groups were acceptable. In the 6-to 8-year-old group, the accuracy of the VGG16 model can reach up to 93.63%, which was higher than the 88.73% accuracy of the ResNet101 network. The age threshold also implies that VGG16 has a smaller age-difference error.

Conclusions
This study demonstrated that VGG16 performed better when dealing with DA estimation via OPGs than the ResNet101 network on a wholescale. CNNs such as VGG16 hold great promise for future use in clinical practice and forensic sciences.
The effect of zingiber officinale on prooxidant-antioxidant balance and glycemic control in diabetic patients with ESRD undergoing hemodialysis: a double-blind randomized control trial
Authors: Rostamkhani Helya , Veisi Parisa , Niknafs Bahram , Jafarabadi Mohammad Asghari , Ghoreishi Zohreh 
Published: February 2023

AbstractBackgroundDiabetes management in hemodialysis patients with end-stage renal disease needs precision to avoid complications. The study aimed to investigate the effect of ginger supplementation on prooxidant-antioxidant balance, glycemic management, and renal function in diabetic hemodialysis patients.Trial design and methodsForty-four patients were randomly allocated to either the ginger or the placebo group in this randomized, double blind, placebo-controlled study. Patients in the ginger group received 2000 mg/d ginger for eight weeks, whereas those in the placebo group received equivalent placebos. After a 12- to 14-h fast, serum levels of fasting blood glucose (FBG), insulin, urea, creatinine, and prooxidant-antioxidant balance (PAB) were measured at baseline and at the end of the study. The homeostatic model evaluation of insulin resistance was used to determine insulin resistance (HOMA-IR).ResultsSerum levels of FBG (p = 0.001), HOMA-IR (p = 0.001), and urea (p = 0.017) were considerably lower in the ginger group compared to baseline, and the difference was significant when compared to the placebo group (p < 0.05). Moreover, ginger supplementation decreased serum levels of creatinine (p = 0.034) and PAB (p = 0.013) within the group, but the effect was insignificant between groups(p > 0.05). On the other hand, insulin levels did not vary significantly across and among the groups(p > 0.05).ConclusionIn summary, this study indicated that in diabetic hemodialysis patients, ginger could result to lower blood glucose levels, enhanced insulin sensitivity, and lower serum urea levels. Further studies with a more extended intervention period and various doses and forms of ginger are needed.Trial registrationIRCT20191109045382N2. (06/07/2020), Retrospectively registered,https://www.irct.ir/trial/48467
Preparedness of primary health care facilities on implementation of essential non-communicable disease interventions in Osun State South-West Nigeria: a rural–urban comparative study
Authors: Akinwumi Adebowale Femi , Esimai Olapeju Adefunke , Arije Olujide , Ojo Temitope Olumuyiwa , Esan Oluwaseun Taiwo 
Published: February 2023

Abstract
Background
Global response to the growing burden of non-communicable diseases (NCDs) in developing countries includes the development of WHO Package of Essential Non-communicable Disease Interventions (WHO PEN) for Primary Health Care (PHC). The study assessed the level of preparedness of PHC facilities on implementation of essential NCD interventions in rural and urban Local Government Areas (LGAs) of Osun State, Nigeria.

Methods
The study was a comparative cross-sectional survey. Information was collected from heads of 33 rural and 33 urban PHC facilities and through direct observation on the domains of staff training, basic equipment, diagnostics and essential medicines for cardiovascular diseases, diabetes and chronic respiratory diseases (CRDs) using a semi-structured interviewer administered questionnaire.

Results
Manual sphygmomanometer was found in similar proportions (84.8%) of PHC facilities in rural and urban LGAs. Glucometer was available in 45.5% of the PHC facilities in urban and 33.3% of the PHC facilities in the rural LGAs, the difference was not statistically significant (χ2 = 1.015; p = 0.314). Basic equipment for CRDs were not available in majority of PHC facilities in both locations. Moduretic tablets were the most reported essential NCD medicines, available in 15% of PHC facilities in rural LGAs and none in urban LGAs. The anti-diabetic medicines were not available in any of the PHC facilities in both locations. More than 90% (≥ 30) of the PHC facilities in both locations were not prepared to implement essential interventions for each NCD across domains of staff training and essential medicines. Overall, 97.0% of the PHC facilities in the rural LGAs and all the PHC facilities in urban LGAs were not prepared on implementation of essential interventions for the three NCDs.

Conclusion
The level of preparedness of the PHC facilities on implementation of essential NCD interventions in the rural and urban LGAs of Osun State is very low. Government needs to strengthen the PHC system by providing needed essential medicines, basic diagnostics, equipment, and training of clinical health care workers for implementation of essential NCD interventions in the state.
Fecal microbiota transplantation attenuates Escherichia coli infected outgrowth by modulating the intestinal microbiome
Authors: Wang Yaping , He Yuanyuan , Liang Ying , Liu Han , Chen Xiushuang , Kulyar Muhammad Fakhar-e-Alam , Shahzad Asim , Wei Kunhua , Li Kun 
Published: February 2023

Abstract
Background
Given the crucial role of gut microbiota in animal and human health, studies on modulating the intestinal microbiome for therapeutic purposes have grasped a significant attention, of which the role of fecal microbiota transplantation (FMT) has been emphasized.

Methods
In the current study, we evaluated the effect of FMT on gut functions in Escherichia coli (E. coli) infection by using mice model. Moreover, we also investigated the subsequently dependent variables of infection, i.e., body weight, mortality, intestinal histopathology, and the expression changes in tight junction proteins (TJPs).

Results
The FMT effectively decreased weight loss and mortality to a certain extent with the restoration of intestinal villi that resulted in high histological scores for jejunum tissue damage (p < 0.05). The effect of FMT on alleviating the reduction of intestinal TJPs was also proved by immunohistochemistry analysis and mRNA expression levels. Moreover, the abundance of health-threatening bacteria, belonging to phylum Proteobacteria, family Enterobacteriaceae and Tannerellaceae, genus Escherichia-Shigella, Sphingomonas, Collinsella, etc., were significantly increased, whereas beneficial bacteria, belonging to phylum Firmicutes, family Lactobacillaceae, genus Lactobacillus were decreased in the gut of infected mice. Furthermore, we sought to investigate the association of clinical symptoms with FMT treatment with modulation in gut microbiota. According to beta diversity, the microbial community of gut microbiota results reflected the similarities between non-infected and FMT groups. The improvement of the intestinal microbiota in FMT group was characterized by the significant high level of beneficial microorganisms with the synergistic decrease of Escherichia-Shigella, Acinetobacter, and other taxa.

Conclusion
The findings suggest a beneficial host-microbiome correlation following fecal microbiota transplanatation for controlling gut infections and pathogens-associated diseases.
Structural violence and the uncertainty of viral undetectability for African, Caribbean and Black people living with HIV in Canada: an institutional ethnography
Authors: Odhiambo Apondi J. , O’Campo Patricia , Nelson La Ron E. , Forman Lisa , Grace Daniel 
Published: February 2023

AbstractBiomedical advances in healthcare and antiretroviral treatment or therapy (ART) have transformed HIV/AIDS from a death sentence to a manageable chronic disease. Studies demonstrate that people living with HIV who adhere to antiretroviral therapy can achieve viral suppression or undetectability, which is fundamental for optimizing health outcomes, decreasing HIV-related mortality and morbidity, and preventing HIV transmission. African, Caribbean, and Black (ACB) communities in Canada remain structurally disadvantaged and bear a disproportionate burden of HIV despite biomedical advancements in HIV treatment and prevention. This institutional ethnography orients to the concept of ‘structural violence’ to illuminate how inequities shape the daily experiences of ACB people living with HIV across the HIV care cascade. We conducted textual analysis and in-depth interviews with ACB people living with HIV (n = 20) and health professionals including healthcare providers, social workers, frontline workers, and health policy actors (n = 15). Study findings produce a cumulative understanding that biomedical HIV discourses and practices ignore structural violence embedded in Canada’s social fabric, including legislation, policies and institutional practices that produce inequities and shape the social world of Black communities. Findings show that inequities in structural and social determinants of health such as food insecurity, financial and housing instability, homelessness, precarious immigration status, stigma, racial discrimination, anti-Black racism, criminalization of HIV non-disclosure, health systems barriers and privacy concerns intersect to constrain engagement and retention in HIV healthcare and ART adherence, contributing to the uncertainty of achieving and maintaining undetectability and violating their right to health. Biomedical discourses and practices, and inequities reduce Black people to a stigmatized, pathologized, and impoverished detectable viral underclass. Black people perceived as nonadherent to ART and maintain detectable viral loads are considered “bad” patients while privileged individuals who achieve undetectability are considered “good” patients. An effective response to ending HIV/AIDS requires implementing policies and institutional practices that address inequities in structural and social determinants of health among ACB people.
Formate-induced CO tolerance and methanogenesis inhibition in fermentation of syngas and plant biomass for carboxylate production
Authors: Baleeiro Flávio C. F. , Varchmin Lukas , Kleinsteuber Sabine , Sträuber Heike , Neumann Anke 
Published: February 2023

AbstractBackgroundProduction of monocarboxylates using microbial communities is highly dependent on local and degradable biomass feedstocks. Syngas or different mixtures of H2, CO, and CO2can be sourced from biomass gasification, excess renewable electricity, industrial off-gases, and carbon capture plants and co-fed to a fermenter to alleviate dependence on local biomass. To understand the effects of adding these gases during anaerobic fermentation of plant biomass, a series of batch experiments was carried out with different syngas compositions and corn silage (pH 6.0, 32 °C).ResultsCo-fermentation of syngas with corn silage increased the overall carboxylate yield per gram of volatile solids (VS) by up to 29% (0.47 ± 0.07 g gVS−1; in comparison to 0.37 ± 0.02 g gVS−1with a N2/CO2headspace), despite slowing down biomass degradation. Ethylene and CO exerted a synergistic effect in preventing methanogenesis, leading to net carbon fixation. Less than 12% of the electrons were misrouted to CH4when either 15 kPa CO or 5 kPa CO + 1.5 kPa ethylene was used. CO increased the selectivity to acetate and propionate, which accounted for 85% (electron equivalents) of all products at 49 kPa CO, by favoring lactic acid bacteria and actinobacteria overn-butyrate andn-caproate producers. Inhibition ofn-butyrate andn-caproate production by CO happened even when an inoculum preacclimatized to syngas and lactate was used. Intriguingly, the effect of CO onn-butyrate andn-caproate production was reversed when formate was present in the broth.ConclusionsThe concept of co-fermenting syngas and plant biomass shows promise in three aspects: by making anaerobic fermentation a carbon-fixing process, by increasing the yields of short-chain carboxylates (propionate and acetate), and by minimizing electron losses to CH4. Moreover, a model was proposed for how formate can alleviate CO inhibition in certain acidogenic bacteria. Testing the fermentation of syngas and plant biomass in a continuous process could potentially improve selectivity ton-butyrate andn-caproate by enriching chain-elongating bacteria adapted to CO and complex biomass.
Inadvertent intrathecal drug injection while treating low back pain: a case report and review of the literature
Authors: Ferrieri Alessandro , Bosco Donatella , Polilli Ennio , Ciulli Raffaella , Visocchi Lina , Mincione Lucrezia , Iacoe Rosa , Zocaro Rosamaria , Frattari Antonella 
Published: February 2023

Abstract
Background
Undesired intrathecal injections represent an important subset of medical errors, albeit rare. Clinical effects depend on the type and concentration of drug(s) injected. Here we report on the case of a healthy woman with persistent low back pain, treated with a paravertebral injection of lidocaine, thiocolchicoside, and l-acetylcarnitine at an orthopedic practice.

Case report
A 42-year-old Caucasian woman, with no relevant past medical history, received a lumbar paravertebral injection of lidocaine, thiocolchicoside, and l-acetylcarnitine for persistent low back pain. Approximately 30 minutes after injection, she experienced quick neurological worsening. Upon arrival at the Emergency Department, she was comatose, with fixed bilateral mydriasis, trismus, and mixed acidosis; seizures ensued in the first hours; slow progressive amelioration was observed by day 6; retrograde amnesia was the only clinical relevant remaining symptom by 6 months.

Conclusions
To our knowledge, this is the first reported case of inadvertent intrathecal thiocolchicoside injection in an adult patient, as well as the first in the neurosurgical literature. Our experience suggests that injection therapy for low back pain should be administered in adequate settings, where possible complications may be promptly treated.
Towards cyber-biosecurity by design: an experimental approach to Internet-of-Medical-Things design and development
Authors: Elgabry Mariam 
Published: February 2023

AbstractThe introduction of the internet and the proliferation of internet-connected devices (IoT) enabled knowledge sharing, connectivity and global communications. At the same time, these technologies generated a crime harvest as security was overlooked. The Internet-of-Medical-Things (IoMT) generates biological information and is transforming healthcare through the introduction of internet-connected medical-grade devices that are integrated with wider-scale health networks to improve patients’ health. Many innovative ideas arise from academia; however, there is a lack of support in medical device regulation. The implementation of the current regulatory framework is limited to security risk assessment and guidance. Unfortunately, premarket risk-management requirements of current regulation do not include crime risks and a more predictive approach could help fill this gap. Crime science, or the perspective of crime as an event that can be influenced directly by its immediate environment, may encourage the biotechnology industry to design-in security and crime out. In this article, I provide a point of view of an early career researcher and medical device developer navigating the medical device regulatory pathway for the first time. I narrow the focus of this article to an assessment that is specific to current UK provisions and acknowledge the limited scope. In response to the ongoing changes in the current regulatory framework of the UK, I propose a new secure by design mechanism that can be employed by early career developers earlier in the development process of a product. Such a model can be used to systematically consider security design in devices and to understand and address potential crime risks ahead of their widespread use.
Experimental research on the performance of a Novel Geo-filament anchor for an Earthen architectural site
Authors: Yulan Wang , Jian Guo , Weixi Zhang , Fan Lei 
Published: February 2023

Abstract
At present, most studies of anchorage techniques for earthen architecture ruins are conducted so as to improve the anchor force, however, the damage caused to the ruins by anchor reinforcement has not been fully considered in practice and no special anchor technique has been applied to reinforce the small sliding mass. This paper summarizes the application and R&D of anchor rod techniques as applied to the protection of the Gaochang Ruins, Turpan, in China. Based on the reinforcement of the small sliding mass of the earthen historical ramparts, a new type of Geotechnical Filament Anchor (GFA) is designed. By changing six parameters, including anchorage length (L), GF thickness (H), bore diameter (D), slurry strength (S), GFA surface state (R) and inclination Angle (A), the tensile strength, failure mode, load displacement (P-S) relationship and strain (ζ-L) distribution characteristics are studied, and corresponding analysis is performed on the test data and phenomena. (1) A formula for the design value of the anchorage force N is presented. (2) Combining the data on the strain distribution at the GF-slurry interface under the action of N, the shear stress distribution model of the anchorage system is obtained. (3) Taking into account the soil mechanical properties of the above-mentioned ruins, the shear stress diffusion coefficient (α) is conceptualized, the formula for the shear strength of the grouting material is obtained, and the allowable ranges of L, D, H, R, and S determined. A new design is proposed for the application of anchorage techniques to earthen ruins in the context of protection of cultural relics, which promotes the design and calculation method described in this paper.