bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential of digital health interventions to address health system challenges in Southeast Asia: A scoping review
Authors: Singh Vanita , Johnson K Rosemol , Jacob Anil G. , John Oommen 
Published: January 2025

Objective The World Health Organization (WHO) Southeast Asian region, comprising a quarter of the global population, faces significant healthcare challenges influenced by diverse economic and social conditions. The objective of this study is to map the Digital Health Intervention (DHI) functionalities across the nine axes of the healthcare system challenges (HSCs) model; we use WHO's DHIs classification framework and the Health System Challenges model. Our study findings help identify the gaps in the potential of the existing DHIs in addressing health system challenges in low- and middle-income countries. Methods Using SCOPUS, EMBASE and PUBMED databases, a scoping review was conducted to identify the existing DHIs in the Southeast Asia region and map the DHIs with the HSCs related to availability, information, utilization, quality, accountability, efficiency, equity, cost and acceptability. Results Out of 278 studies, 337 DHI functionalities were identified. A majority of the identified DHIs address challenges related to information (35.6%), availability (34.7%) and utilization, while less than 10% of the DHIs address challenges related to quality (8.9%), accountability (5%) and efficiency (3.9%) in the health system. Conclusion Most of the existing DHIs in SEA region address challenges related to availability of services and lack of information, while they fall short in addressing challenges related to quality of services, efficiency, and accountability. Acknowledging the inter-linkages across the health system challenges, this gap identification may well guide future investments and planning in DHIs.
Acute Effects of Unplanned and Planned Hop-Landing Training on Neurocognitive Function and Knee Biomechanics
Authors: Konishi Mika , Clark Nicholas C. , McDonald Duncan J. , Takemura Masahiro , Cortes Nelson 
Published: January 2025

Background: Athletes with decreased baseline neurocognitive function may experience noncontact anterior cruciate ligament (ACL) injury in unanticipated athletic situations. Many ACL injury prevention programs (IPPs) focus on improving closed-skill movements (eg, planned landing). However, the more open-skill movements (eg, unplanned reactive movements) required in unpredictable sports scenarios are commonly absent from ACL IPPs, and the acute effects of open-skill training on neurocognitive function remain unclear. Purpose: To investigate the acute effects of unplanned versus planned training on neurocognitive function and knee biomechanics associated with ACL injury risk during the side-step cutting motion. Study Design: Controlled laboratory study. Methods: A total of 32 adult recreational athletes (16 female, 16 male) were randomly assigned to either an unplanned training (UT) group or a control (CON) group. The UT group performed unplanned hop-landing training while the CON group performed planned hop-landing training. Both before and after the training, neurocognitive function was evaluated using the Trail Making Test–part B and Stroop Color and Word Test. Additionally, unanticipated and anticipated side-step cutting tasks were performed while 3-dimensional kinematic and kinetic data for the dominant leg were collected. Neurocognitive test scores and biomechanical variables relevant to ACL injury were analyzed using 2-way repeated-measures analysis of variance to determine the main effects of training, group, and training × group interaction. Results: Trail Making Test–part B and Stroop Color and Word Test scores significantly improved from pre- to posttraining in both groups ( P < .001 for both). There was a significant training × group interaction for peak knee abduction angle during the unanticipated side-step cutting task (pre- vs posttraining: –8.81°± 7.23° vs −7.40°± 7.24° [UT group]; –8.23°± 9.40° vs −9.99°± 9.83° [CON group]; P = .02) and for peak vertical ground-reaction force during the anticipated side-step cutting task (pre- vs posttraining: 3.86 ± 0.59 vs 4.08 ± 0.74 percentage body weight [%BW] [UT group]; 3.70 ± 0.62 vs 3.34 ± 0.62 %BW [CON group]; P = .04). Conclusion: Study findings showed a significant training × group interaction for knee abduction angle during the unanticipated side-step cutting task with unplanned training and for vertical ground-reaction force during the anticipated side-step cutting task with planned training. Clinical Relevance: Designing ACL IPPs based on the sport type (ie, open skill or closed skill) may contribute to better preparation.
Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial
Authors: McIlroy Graham , Gaskell Charlotte , Jackson Aimee , Yafai Emily , Tasker Rachel , Thomas Catherine , Fox Sonia , Boucher Rebecca , Ghebretinsea Fitsum , Harrison Claire , Mead Adam J. , McMullin Mary Frances 
Published: January 2025

Abstract
Background
Myelofibrosis (MF) is a clonal haematopoietic disease, with median overall survival for patients with primary MF only 6.5 years. The most frequent gene mutation found in patients is JAK2V617F, causing constitutive activation of the kinase and activation of downstream signalling. Fedratinib is an oral selective JAK2 inhibitor. It has shown activity in MF and is well-tolerated, but combination with other therapies is likely needed to achieve clonal remission. Combining a JAK2 inhibitor with an interferon may be synergistic, as haematopoietic cells are activated from quiescence (a typical kinase resistance mechanism) rendering them more sensitive to inhibition.
Ropeginterferon alfa-2b is a next generation pegylated interferon-α-2b with high tolerability and clinical activity in patients with MF, however, evidence of tolerability and activity in combination with fedratinib is lacking in this setting. The aim of the FEDORA trial is to assess tolerability, safety, and activity of fedratinib with ropeginterferon alfa-2b in patients with MF who require treatment to justify further investigation in a phase III trial.

Methods
FEDORA is a single arm, multicentre, open-label, Bayesian phase II trial to assess tolerability, safety, and activity of fedratinib with ropeginterferon alfa-2b aiming to recruit 30 patients. Patients with JAK2V617F positive primary or secondary MF, who are aged ≥ 18 years, have intermediate-1 with palpable splenomegaly of > 5cm, intermediate-2, or high-risk disease according to the Dynamic International Prognostic Scoring System (DIPSS), and who require treatment are eligible. The primary outcome is tolerability, whereby the combination is deemed intolerable in a patient if drug-related toxicities in the first four months of treatment lead to: either drug being discontinued; delays in treatment exceeding 28 consecutive days; or death. FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable.

Discussion
FEDORA is using a Bayesian trial design and aims to provide evidence of the tolerability, safety, and activity of combining fedratinib with ropeginterferon alfa-2b upon which the decision as to whether a phase III trial is warranted will be based.

Trial registration
EudraCT number: 2021–004056-42.
ISRCTN: 88,102,629.
A study protocol for individualized prognostic counselling in the palliative phase
Authors: van den Besselaar Boyd Noël , Sewnaik A. , Dorr M. C. , Hoesseini A. , Hardillo J. A. , Baatenburg de Jong R. J. , Offerman M.P.J. 
Published: January 2025

Abstract
Background
Head and neck squamous cell cancer (HNSCC) has a poor prognosis, with approximately 25–30% of patients transitioning into the palliative phase at some point. The length of this phase is relatively short, with a median duration of five months. Patients in this stage often have increased prognostic information needs. Unfortunately, predicting individual life expectancy in this phase is particularly challenging, as physicians and patients tend to overestimate survival. To address this issue, we developed the prognostic model OncologIQ Palliative based on user preferences. In this study, we now aim to assess the clinical impact of utilizing this model during counselling.

Methods
This study will employ both quantitative and qualitative approaches. The primary outcome is decisional conflict and satisfaction with the decision-making process after counselling without (cohort 1) and with (cohort 2) OncologIQ Palliative. Therefore, a prospective sequential cohort study will be conducted. Secondary outcomes include the amount of palliative treatment, overall survival rates, and quality of life. These measurements will be collected after the intervention. Additionally, patients’ perspectives on the decision-making process and proactive care planning, including end-of-life discussions, will be explored through interviews.

Discussion
By offering more personalized prognostic information for HNSCC patients in the palliative phase, we anticipate a shift towards more patient-centred counselling. This approach can facilitate enhanced end-of-life discussions and better proactive care planning. Patients may experience reduced decisional conflict, feel better prepared for what’s coming, and find assistance in their decision-making process. This could potentially lead to fewer palliative treatments. Overall, these aspects can contribute to a better quality of life and quality of care for HNSCC patients in the last phase of their lives.

Trial Registration
This study was registered November 18, 2024, on ClinicalTrials.gov: NCT06699316.
Development and validation of a novel coronary artery disease risk prediction model
Authors: Wu Zu-Fei , Tao Si-Xiao , Su Wen-Tao , Chen Shi , Xu Bai-Da , Zong Gang-Jun , Wu Gang-Yong 
Published: January 2025

Abstract
Objective
This study aims to develop a novel risk assessment tool for coronary artery disease (CAD) based on data of patients with chest pain in outpatient and emergency department, thereby facilitating the effective identification and management of high-risk patients.

Methods
A retrospective analysis was conducted on patients hospitalized for chest pain. Patients were divided into a control group and a CAD group based on angiographic results. Logistic regression was used to identify factors associated with CAD, and R-Studio was utilized to construct the CAD risk prediction model.

Results
Multivariate logistic regression analysis indicated that age, gender, diabetes, ECG (electrocardiogram) ST-T changes, neutrophils (NE), coronary artery calcification (CAC), and typical chest pain were independent factors associated with CAD. Based on the results of multifactorial logistic analysis, the CAD risk prediction model built with R-Studio had a highest C-index of 0.909, and a validation cohort C-index of 0.897, demonstrating excellent predictive ability. Decision Curve Analysis showed that the model significantly outperformed others in terms of clinical net benefit.

Conclusion
The present study successfully developed a CAD risk assessment model based on Chinese population. This novel model could be used to assess CAD risk in patients with chest pain, optimize clinical decision making, and improve patient outcomes, regardless of whether it is applied in large hospitals or resource-limited Community Healthcare Center.
Impact of an online mindfulness-based program on wellbeing and trait mindfulness for research postgraduate students: a randomized-controlled trial
Authors: Xu Jia-Qi , Tang Yee-Man Jennifer , Chen Hoi Ying Katherine 
Published: January 2025

Abstract
Objectives
Pursuing a research postgraduate (RPg) degree is a major life event and could be stressful. The current study aims to explore the effectiveness of an online eight-week mindfulness-based intervention on improving wellbeing and alleviating illbeing among a group of RPg students using a randomized waitlist-controlled design.

Methods
A total of 88 RPg students, either studying in Hong Kong or Macau, were recruited (43 were randomized into the immediate intervention group; 67 females; mean age = 27.7; SD = 4.60). The “Finding Peace in a Frantic World” was adopted as the mindfulness-based program. Linear mixed models were applied to test the effects of the intervention on trait mindfulness, compassion, wellbeing related measures (i.e., subjective wellbeing, resilience, wellbeing literacy) and illbeing related measures (i.e., emotional and sleeping disturbances), while controlling for the effects of age and gender. The intervention group was also assessed at two-month follow-up to evaluate the sustained effects.

Results
The results revealed that participants from the intervention group showed increased resilience (b = 0.88, p = .012), wellbeing literacy (b = 2.52, p = .04), trait mindfulness (b = 5.16, p = .006), and decreased emotional disturbances (b=-8.24, p = .015), while there were no changes in subjective wellbeing, sleeping quality, and self-compassion or compassion towards others compared to the waitlist controls. Positive effects were sustained after two months in the intervention group.

Conclusions
This study provides evidence for online mindfulness training in alleviating RPg students’ emotional disturbance and supporting their resilience and wellbeing literacy.

Registration
The study was retrospectively registered with the ISRCTN Registry on 11/11/2022 (registration number: ISRCTN18262344).
Antipsychotic continuation during pregnancy and risk of postpartum relapse in women with schizophrenia: nationwide register-based study
Authors: Kang Sunghyuk , Yang Ji Su , Yun Bo Hyon , Gelaye Bizu , An Suk Kyoon , Jung Sun Jae 
Published: January 2025

Background
Women with schizophrenia frequently discontinue antipsychotic medications during pregnancy. However, evidence on the risk of postpartum relapse associated with antipsychotic use during pregnancy is lacking.

Aims
To investigate the within-individual association between antipsychotic continuation during pregnancy and postpartum relapse in women with schizophrenia.

Method
This retrospective cohort study used data of women with schizophrenia who gave live birth between 2007 and 2018 identified from the National Health Information Database of South Korea. Women were classified according to antipsychotic use patterns during the 12 months before delivery as non-users, discontinuers and continuers. Relapse was defined as admission for psychosis (ICD-10, F20–29). The incidence rate ratio (IRR) for admission for psychosis in the 6-month postpartum period was estimated using conditional Poisson regression, with the reference period set between 2 and 1 years before delivery. Additionally, we calculated the relative risk ratios (RRRs) for the IRRs of different antipsychotic use patterns.

Results
Among the 3026 women included in the analysis (median age 34 years, interquartile range 31–37), the within-individual risk of admission for psychosis in the 6-month postpartum period was 0.56 times (RRR, 95% CI 0.36–0.87) lower in continuers (IRR = 1.31, 95% CI 0.89–1.72) than in discontinuers (IRR = 2.34, 95% CI 1.87–2.91). Among discontinuers, the IRRs of admission for psychosis in the 6-month postpartum period did not change significantly with the timing of discontinuation (trend P = 0.946).

Conclusions
Antipsychotic continuation during pregnancy was associated with a reduced risk of postpartum relapse in women with schizophrenia. Continuing antipsychotics during pregnancy would be recommended after a risk–benefit assessment.
Defining and Measuring Financial Toxicity in Low- and Middle-Income Countries
Authors: Raptis Stephanie G. , Shkabari Brian , Banday Saquib , Gyawali Bishal 
Published: January 2025

PURPOSE
Financial toxicity (FT) of cancer treatment likely affects more patients in low- and middle-income countries (LMICs); however, most of the research on FT comes from high-income countries, which may not apply to LMICs. The causes and consequences of FT in patients with cancer in LMICs remain understudied.

METHODS
Following PRISMA guidelines, we searched MEDLINE, Web of Science, and CINAHL for FT literature in cancer originating from LMICs from inception until the end of 2023, and documented the different definitions used to define FT in LMICs, and the magnitude of FT documented using those definitions. LMIC was defined using the World Bank Country and Lending Group classification.

RESULTS
Sixty-eight studies met the inclusion criteria. Studies on FT in cancer originating from LMICs have increased in recent years (>75% studies published 2020 onward) and used varying criteria to define FT, broadly categorized into five themes. Majority of the studies defined FT in terms of catastrophic health expenditure (45%) or household impoverishment (10%), while 26% of the studies used the Comprehensive Score for Financial Toxicity tool, developed and validated in US patients, to measure FT in LMIC settings. Twenty-six percent of the studies defined FT in terms of coping mechanisms and 10% in terms of subjective financial burden. The magnitude of FT in patients with cancer was substantial irrespective of the definitions used.

CONCLUSION
This review synthesizes the different definitions of FT for LMICs that have been used in the literature so far. We conclude that the definitions that capture the coping mechanisms or hardships might reflect the magnitude of FT better than absolute dollar values or relative percentages of expenditures. Future studies can use our results to devise locally tailored definitions of FT.
Parterre Ornamentation in the Publications of the 16th–17th Centuries
Authors: Nutt Nele 
Published: January 2025

Sixteenth and seventeenth century publications afford a great overview of contemporary park designs. Thanks to the surviving books we are able to study the park design of the end of the Renaissance, the Mannerist period and the beginning of the Baroque. That entire garden design period is characterised by the use of parterres. While plant ornamentation is heavily used throughout the period, we do not find as much animal ornamentation in the designs. Dolphins, as important symbols of love and friendship, were beloved figures in park design. In addition to parterre designs, Dolphins can be found in water feature ensembles, fountain groups and grotto niches.
Posterior reversible encephalopathy syndrome related to severe hypomagnesaemia
Authors: Naya Rosato Martín , Núñez Calvo María Luisa , Barrera López Lucía 
Published: January 2025

Introduction: Posterior reversible encephalopathy syndrome (PRES) might be associated with a wide spectrum of symptoms, including irreversible neurological damage. Management is primarily symptomatic and focuses on addressing the underlying causes. Case description: A 65-year-old female with a medical history of smoking, arterial hypertension and dyslipidaemia, was admitted due to dysarthria associated with ataxia, visual disturbances and diarrhoea. The neurological physical examination revealed a mild decreased strength in both legs (4/5), mild dysdiadochokinaesia and mild heel-knee dysmetria. Remarkable laboratory findings showed potassium 2.6 mmol/l and magnesium 0.24 mg/dl. Brain computed tomography (CT) showed no suggestive ischaemic areas. During hospitalisation, potassium and magnesium levels were initially corrected through intravenous supplementation. A brain magnetic resonance imaging (MRI) scan revealed symmetrical cortical alterations in the posterior regions of both cerebellar hemispheres, consistent with a diagnosis of PRES. After the exclusion of other potentially related diseases, the final diagnosis was PRES in the setting of severe hypomagnesaemia. Discussion: PRES pathophysiology is unknown, while its incidence is probably underestimated. It is suggested that rapid increases in blood pressure are thought to overwhelm the self-regulatory capability of cerebral blood flow, especially in the posterior brain regions where the regulatory flow capacity may be weaker. This might result in increased cerebral perfusion leading to oedema due to capillary leakage. PRES has been associated with poorly controlled arterial hypertension, autoimmune diseases, eclampsia and chemotherapy, among others. Conclusion: Hypomagnesaemia represents an uncommon but potentially reversible cause of PRES and should be taken into account for differential diagnosis.
Laser-induced damage thresholds in SiO2-coated aluminum mirrors under various ultrashort pulse widths
Authors: Zhu YongJian , Ma Yunfeng , Cheng Wang , Zhang Zhixi , Kang Wenyun , Bai Fang , Cao ChenXin , Guo Guangyan , Chow Yasong , Zhong Tao , Zhao Tianzhuo , Fan Zhongwei 
Published: January 2025

The influence of laser temporal parameters on the laser-induced damage threshold (LIDT) is particularly complex due to the variation and uncertainty in damage mechanisms associated with different pulse widths, especially in the range that bridges transitional damage mechanisms. Metallic mirrors are ideally suited for ultrashort pulse optical systems owing to their broad spectral range. A comprehensive understanding of the damage behavior of metallic mirrors under ultrashort pulse widths is crucial for optimizing their performance and manufacturing processes. Consequently, a laser damage testing platform was established in the laboratory to conduct 1-on-1 and area-based damage testing method on SiO2-coated aluminum mirrors, covering a pulse width range of 0.2 to 11 ps. The experimental results revealed two transitions in the LIDT from 0.2 to 11 ps. Specifically, within the 0.3 to 8 ps pulse width range, the LIDT inversely correlated with the pulse width, adhering to a power-law relationship. Conversely, for pulse widths below 0.3 ps and between 8 and 11 ps, the LIDT positively correlated with the pulse width. Observations using optical microscopy and scanning electron microscopy (SEM) exhibited the damage morphology at different pulse widths, which indicated that damage initially occurred in the SiO2 dielectric film on the sample surface, demonstrating a transition in the laser damage mechanism across the experimental pulse width range.
High-efficiency tunable lasers hybrid-integrated with silicon photonics at 2.0  μm
Authors: Xie Yuxuan , McDonald Corey A. , Morin Theodore J. , Zhou Zhican , Peters Jonathan , Bowers John E. , Wan Yating 
Published: January 2025

We present hybrid tunable lasers at 2.0-μm wavelength, seamlessly integrated within silicon photonic circuits for advanced biomedical applications. Leveraging III/V semiconductor materials for gain and silicon ring resonators for tuning, the laser achieves a tuning range of 25 nm, precise adjustments below 0.1 nm, and a side-mode suppression ratio of 40 dB. This advancement contributes to the progress in photonic integrated circuits beyond the telecommunication wavelength range, offering scalable and cost-effective solutions for enhanced spectroscopic systems within the 2.0-μm wavelength range.