bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-chain fatty acyl-coenzyme A activates the mitochondrial fission factors MiD49 and MiD51 by inducing their oligomerization
Authors: Liu Ao , Kage Frieda , Sapp Gracie , Aydin Halil , Higgs Henry N. 
Published: July 2023

AbstractMitochondrial fission occurs in many cellular processes, but the regulation of fission is poorly understood. We show that long-chain acyl coenzyme A (LCACA) activates two related mitochondrial fission proteins, MiD49 and MiD51, by inducing their oligomerization, activating their ability to stimulate DRP1 GTPase activity. The 1:1 stoichiometry of LCACA:MiD in the oligomer suggests interaction in the previously identified nucleotide-binding pocket, and a point mutation in this pocket reduces LCACA binding and LCACA-induced oligomerization for MiD51. In cells, this LCACA binding mutant does not assemble into puncta on mitochondria or rescue MiD49/51 knock-down effects on mitochondrial length and DRP1 recruitment. Furthermore, cellular treatment with the fatty acid analogue 2-bromopalmitate, which causes increased acyl-CoA, promotes mitochondrial fission in an MiD49/51-dependent manner. These results suggest that LCACA is an endogenous ligand for MiDs, inducing mitochondrial fission and providing a potential mechanism for fatty acid-induced mitochondrial fragmentation. Finally, MiD49 or MiD51 oligomers synergize with MFF, but not with actin filaments, in DRP1 activation, suggesting distinct pathways for DRP1 activation.
A multi-disciplinary view on a corporate real estate alignment model
Authors: Cooke Howard , Appel-Meulenbroek Rianne 
Published: July 2023

Purpose
The purpose of this paper is to examine a recent comprehensive corporate real estate (CRE) alignment model which was derived from previous CRE alignment models. This study proposes several modifications and additions based on business and decision-making literature to increase the framework’s multidisciplinary strength and extend its implementation phase.

Design/methodology/approach
Literature from various fields is reviewed and “lessons” incorporated into the framework. The business literature review began with corporate strategy theories cited in CRE alignment theory and extended to critiques of those and more recent theories. Likewise, decision-making and implementation both began with material cited in CRE literature and “rippled” out to encompass pertinent material.

Findings
The model used provides a robust framework, and this study has identified several areas that would appear to improve that model from a theoretical and practical perspective. Areas of further research are identified that appear to offer opportunities to further develop the framework.

Originality/value
Historically, there has been a tendency for new CRE alignment models to be created rather than existing ones being developed further. Here, a framework derived from a meta-study of CRE alignment models is reviewed, and improvements are proposed to further develop CRE alignment theory and its application in practice through the addition of viewpoints from the business field and more focus on the implementation phase of the model.
The mediation model of learning organization, technology acceptance and service innovation: Part I
Authors: Kalıpçı Mehmet Bahadır 
Published: July 2023

Purpose
This paper aims to create a conceptual model that connects learning organizations, service innovation and technology acceptance.

Design/methodology/approach
The importance of the interaction of variables benefiting both individuals and organizations has been comprehensively explained by combining two well-known theories – learning organizational theory and service innovation theory – with the technology acceptance model. In the first part of the study, conceptual model has been constructed and then applied to the hospitality industry of which results have been presented in the second part of this paper.

Findings
It is hypothesized that learning organization, service innovation and technology acceptance have significant relationships. It is also suggested that the learning organization plays an intermediary role in the relationship between technology acceptance and service innovation. Empirical results in this regard have been presented in the second part of the paper.

Research limitations/implications
The relations have been established and tested in the hospitality industry in Antalya. However, the model can be applied and established relations tested in other industries.

Originality/value
This research contributes to our knowledge of the intricate linkages that exist between learning organizations, technology acceptance and service innovation. Originality of the paper is related to the novel multilayered model illustrating three-way interactions between the three dimensions of learning organization, technology acceptance and service innovation.
Functional traits of both specific alien species and receptive community but not community diversity determined the invasion success under biotic and abiotic conditions
Authors: Hou Meng , Wang Jianyong 
Published: July 2023

Abstract

Biodiversity can provide some resistance to alien species in some cases, but not in others. The observed paradoxical results may be related to several reasons, including variations in abiotic and/or biotic conditions, alien species characteristics and the fact that the species number cannot adequately reflect native community diversity. A comprehensive study that incorporates these elements is lacking.

We constructed invasion systems using nine alien plant species and 12 native communities, composed of two diversity levels (three vs. six species), under different nitrogen (N) and arbuscular mycorrhiza fungi (AMF) inoculation conditions. We used this fully crossed factorial experiment, that is, N (low vs. high) × native community diversity (three vs. six species) × AMF (with vs. without), to systematically explore the invasion success in native communities.

We found that the species number of native community did not affect invasion success under any of the N or AMF conditions. The effects of N enrichment and AMF inoculation on invasion were not consistent between alien species and native communities based on their phenotypic plasticity of functional traits in response to N enrichment and AMF inoculation. Specifically, the changing of invasion in response to N enrichment and AMF inoculation was associated with the plasticity of plant height and root mass fraction that reflects the competitiveness for the acquisition of light and soil resources.

Our results that species number did not capture well the resistance of the native community suggested that the simple expression of species richness is not realistic to describe the invasion resistance of the community. Additionally, the association between functional traits of both alien species and native communities and invasion success suggested that changes in competitive advantage and resource acquisition strategy are more important in explaining changes in invasive success in different N and AMF conditions.

Future studies are needed to explore invasion success by systematically considering the characteristics of invasive species and the native community, and the specific abiotic and biotic conditions. Using functional traits may help advance our understanding of plant invasion in broad circumstances and shed light on a generalized framework of biological invasion.

Read the free Plain Language Summary for this article on the Journal blog.
Home‐schooling in the Republic of Ireland
Authors: Banks Joanne , Forlin Chris , Chambers Dianne 
Published: July 2023

AbstractInternationally, there continues to be a rise in the popularity of home‐schooling. Although the growth in the numbers of families choosing this alternative approach was evident prior to the Covid‐19 Pandemic school closures, it appears to have impacted on the decision for some to home‐school permanently. Using a scoping review of the literature, this paper considers the research evidence around home‐schooling in the United Kingdom and Europe. It then focuses on home‐schooling in the Republic of Ireland to assess the change and development of home‐schooling over time. In line with trends internationally, Irish administrative data show an increase in the numbers of families engaging in home‐schooling in recent years, particularly for students with disabilities. The paper situates these findings within the context of ongoing debates on inclusive and special education in Ireland and the capacity of mainstream schools to educate and include every student.
Balancing conservation and welfare in ex situ management of the extinct‐in‐the‐wild sihek: sex‐ and age‐specific causes of mortality and contributions to population growth rate
Authors: Trask A. E. , Carraro C. , Kock R. , McCrea R. , Newland S. , Royer E. , Medina S. , Fontenot D. , Ewen J. G. 
Published: July 2023

AbstractEx situ threatened species management has both conservation and welfare objectives and these objectives often align, but can diverge. Areas of agreement can present win‐wins for achieving welfare and conservation objectives, while identifying areas of divergence is important to ensure management strategies achieve balance across objectives. We examined welfare and conservation objectives in the ex situ population of Extinct in the Wild sihek (Guam kingfisher, Todiramphus cinnamominus) by quantifying mortality rates, determining sex‐ and age‐specific causes of mortality and identifying associated welfare domains, as well as quantifying sex‐ and age‐specific differences in reproductive value and contributions to variation in population growth rate (λ). Females had significantly higher mortality rates than males, potentially impacting population viability and suggesting females may be more vulnerable to experiencing lower welfare than males. Mitigating causes of female mortality would therefore present a clear win‐win for both welfare and conservation objectives. Both causes of mortality and contributions to variation in λ were found to differ across sex‐ and age‐classes. In particular, nutritional and metabolic diseases tended to impact younger age‐classes and these age‐classes had large contributions to variation in λ. Mitigation of these diseases could therefore also present a win‐win for welfare and conservation objectives. However, we also identified a potential divergence between objectives: a major cause of female mortality was reproductive disease with older aged females primarily affected, but older aged females contributed little to variation in λ and had low reproductive value. Developing mitigation strategies for reproductive disease could therefore aid welfare objectives but have little benefit for conservation objectives, suggesting careful balancing across objectives is required. Our results highlight the need to explicitly consider conservation and welfare objectives in threatened species management, in particular in the context of an increasing conservation need for ex situ population management, coupled with increasing social concern for animal welfare.
Economic and cost considerations of delivering and using mobile X‐ray services in residential aged care facilities: A qualitative study
Authors: Dollard Joanne , Edwards Jane , Yadav Lalit , Gaget Virginie , Tivey David , Inacio Maria C. , Maddern Guy J. , Visvanathan Renuka 
Published: July 2023

AbstractObjectiveTo describe the economic and cost considerations of mobile X‐ray services (MXS) in residential aged care facilities (RACFs), according to stakeholders (involved in residents' healthcare), residents living in RACFs and informal carers (ICs) of residents.MethodsSemistructured interviews were conducted with 20 residents and 27 ICs recruited from six RACFs across metropolitan Adelaide (South Australia, Australia), and 22 stakeholders, on their perspectives of using MXS in RACFs. Data relating to economic and cost considerations were extracted and analysed using thematic analysis.ResultsResidents' mean age was 85 years, 60% were women and 40% had experienced an MXS in the last 12 months. Most ICs were daughters (70%) and wives (11%) and 30% had a family member who had experienced an MXS in the last 12 months. Stakeholders included RACF staff, GPs, a hospital avoidance program clinician, paramedics, emergency department clinicians, MXS radiographers and manager, and a radiologist. Four themes were presented: (1) business considerations, where private providers found it necessary to charge residents a co‐payment to deliver MXS; (2) cost and payment process as a potential barrier to using MXS, with varied willingness and ability to pay for an MXS co‐payment, and equity concerns; (3) overcoming cost and payment barriers, with staff and consumers sometimes using strategies to overcome cost barriers; and (4) perceived cost benefits of MXS to the healthcare system, residents and ICs.ConclusionsMobile X‐ray services providers charge residents an upfront co‐payment for business viability, which can be a barrier to some residents wishing to access MXS.
The State of Uberisation: Neoliberalism, Smart Urbanism, and the Regulated Deregulation of Toronto's Taxi‐cum‐Ridehail Market
Authors: Namberger Fabian 
Published: July 2023

AbstractIn 2016, the City of Toronto legalised the ridehail giant Uber under a particularly Uber‐friendly regulatory regime. Rather than understanding this interim outcome along the lines of now widespread narratives of corporate “disruption”, in this article I take up Manuel B. Aalbers’ notion of “regulated deregulation” in order to foreground the state's role as a manically prolific facilitator of early Uberisation. Based on ethnographic research in Toronto, I argue that the three longer‐standing state spatial strategies of (1) the common‐sense neoliberal state, (2) the labour‐averse competition state, and (3) the tech‐infatuated smart state were paramount in creating those “on‐the‐ground” conditions—social, legal, spatial, and other—on which Uber has been able to thrive in many cities across the North American continent.
FISH‐ing for answers: Can genomic arrays add to our understanding of disease biology in low‐risk chronic lymphocytic leukaemia?
Authors: Rhodes Joanna 
Published: July 2023

Patients with chronic lymphocytic leukaemia can have an indolent or aggressive clinical course. Current guidelines recommend performing immunoglobin heavy chain testing, four‐colour probe fluorescence in situ hybridization testing and mutational analysis for TP53 mutations as part of routine prognostic testing to determine if high‐risk genomic features are present. Rigolin et al. demonstrate that genomic microarray testing can identify high‐risk genomic features in patients deemed low risk by current testing standards and is independently associated with shorter time to first treatment in their cohort.Commentary on: Rigolin et al. Additional lesions identified by genomic microarrays are associated with an inferior outcome in low‐risk chronic lymphocytic leukaemia patients. Br J Haematol 2023;202:953–959.
Comparative efficacy of digitally assisted interventions for glycated haemoglobin levels among patients with type 2 diabetes: A systematic review and component network Meta‐Analysis
Authors: Romadlon Debby Syahru , Tu Yu‐Kang , Chen Yang‐Ching , Hasan Faizul , Chiu Hsiao‐Yean 
Published: July 2023

AbstractAimsTo compare the efficacy of digitally assisted interventions on the glycated haemoglobin (HbA1c) levels of patients with type 2 diabetes by performing a systematic review, network meta‐analysis and component network meta‐analysis.MethodsSix databases were searched to identify eligible articles from the inception of each database until 17 March 2023. We included randomized controlled trials evaluating HbA1c levels. Data were pooled with a random‐effects model under a frequentist framework. The evidence certainty was assessed using Confidence in Network MetaAnalysis (CINeMA). The PROSPERO registration number was CRD42021283815.ResultsIn total, 75 trials involving 9764 participants were included. Results from standard network meta‐analyses of 17 interventions revealed that compared with standard care, a mobile application (MA) combined with a professional education programme and peer support education (PSE; −1.98, 95% confidence interval = −2.90 to −1.06, CINeMA score: moderate to high) significantly reduced HbA1c levels. The component analysis found that PSE (−1.50, −2.36 to −0.64), SMS (−0.33, −0.56 to −0.11), MA (−0.30, −0.56 to −0.04) and telephone calls (−0.30, −0.53 to −0.06) most effectively reduced HbA1c levels among patients with type 2 diabetes.ConclusionsSMS and MA are the optimal digitally assisted interventions for reducing HbA1c levels. Educators can integrate digitally assisted interventions complemented by educational programmes, particularly MA combined with professional education programme and PSE, into daily care to control HbA1c. The limitations of included trials include a lack of information on allocation concealment and blinding and the fact that long‐term follow‐up effects were not investigated.
Improving accuracy in diagnosing aortic stenosis severity: An in‐depth analysis of echocardiographic measurement error through literature review and simulation study
Authors: Velders Bart J. J. , Groenwold Rolf H. H. , Ajmone Marsan Nina , Kappetein Arie‐Pieter , Wijngaarden Rob A. F. De Lind Van , Braun Jerry , Klautz Robert J. M. , Vriesendorp Michiel D. 
Published: July 2023

AbstractAimsThe present guidelines advise replacing the aortic valve for individuals with severe aortic stenosis (AS) based on various echocardiographic parameters. Accurate measurements are essential to avoid misclassification and unnecessary interventions. The objective of this study was to evaluate the influence of measurement error on the echocardiographic evaluation of the severity of AS.Methods and resultsA systematic review was performed to examine whether measurement errors are reported in studies focusing on the prognostic value of peak aortic jet velocity (Vmax), mean pressure gradient (MPG), and effective orifice area (EOA) in asymptomatic patients with AS. Out of the 37 studies reviewed, 17 (46%) acknowledged the existence of measurement errors, but none of them utilized methods to address them. Secondly, the magnitude of potential errors was collected from available literature for use in clinical simulations. Interobserver variability ranged between 0.9% and 8.3% for Vmax and MPG but was higher for EOA (range 7.7%‐12.7%), indicating lower reliability. Assuming a circular left ventricular outflow tract area led to a median underestimation of EOA by 23% compared to planimetry by other modalities. A clinical simulation resulted in the reclassification of 42% of patients, shifting them from a diagnosis of severe AS to moderate AS.ConclusionsMeasurement errors are underreported in studies on echocardiographic assessment of AS severity. These errors can lead to misclassification and misdiagnosis. Clinicians and scientists should be aware of the implications for accurate clinical decision‐making and assuring research validity.
Dishonesty as a collective‐risk social dilemma
Authors: Jiang Shuguang , Villeval Marie Claire 
Published: July 2023

AbstractWe investigated lying as a collective‐risk social dilemma. Misreporting resulted in increased individual earnings but when total claims reached a certain threshold, all group members were at risk of collective sanction, regardless of their individual behavior. Due to selfishness and miscoordination, most individuals earned less than the reservation payoff from honest reporting in the group. However, preferences for truth‐telling lowered the risk of collective sanction in this setting compared to a social dilemma game in which players could make direct claims without lying. The risk of sanctions decreased with risk aversion and a smaller group size.
A new perspective on hippocampal synaptic plasticity and post‐stroke depression
Authors: Sun Ning , Cui Wen‐Qiang , Min Xiao‐Man , Zhang Guang‐Ming , Liu Jia‐Zheng , Wu Hong‐Yun 
Published: July 2023

AbstractPost‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise molecular mechanisms remain unclear. Numerous studies have found that neurotrophic factors, protein kinases and neurotransmitters influence depressive behaviour by modulating hippocampal synaptic plasticity. This review further elaborates on the role of hippocampal synaptic plasticity in post‐stroke depression by summarizing recent research and analysing possible molecular mechanisms. Evidence for the correlation between hippocampal mechanisms and post‐stroke depression helps to better understand the pathological process of post‐stroke depression and improve its treatment.
Biodiesel Co‐Product (BCP) amendment drives beneficial soil microbiome assembly promoting acid soil health
Authors: Shen Qunli , Voroney Paul , Brookes Philip C. , Elrys Ahmed S. , Yu Mengjie , Su Wei‐Qin , Meng Lei , Li Meng 
Published: July 2023

AbstractBiodiesel Co‐Product (BCP) amendment has been shown to decrease both nitrate leaching and nitrous oxide (N2O) emissions in acidic soil; however, the effects of BCP on the soil microbiome have not been investigated thoroughly. In this study, we investigated the response of prokaryotic and fungal communities in aspects of structure, diversity, and co‐occurrence network to the BCP amendment following complete mixing application (0–18‐cm depth) of 1.5 mg BCP‐C g−1 and surface application (0–6‐cm depth) of 4.5 mg BCP‐C g−1 via high‐throughput 16S rRNA and internal transcribed spacer (ITS) amplicon sequencing. The amendment altered microbial communities significantly by increasing the relative abundances of Proteobacteria (Burkholderia) and Ascomycota (Trichoderma) in prokaryotic and fungal communities, respectively. Only a higher rate application (4.5 mg BCP‐C g−1) decreased prokaryotic alpha diversity, whereas all rates of amendment decreased fungal diversity. The co‐occurrence network of prokaryotes had more nodes and links and a higher average degree and clustering coefficient than the fungal network with BCP addition. The majority of keystone species in prokaryotic and fungal networks were from Proteobacteria and Ascomycota taxa. Of note, the BCP amendment significantly increased the OTU numbers of potential biocontrol agents, including Trichoderma (T.) spirale, T. koningiopsis, and T. virens, etc., while decreased OTU numbers related to plant pathogens species, particularly in the complete mixing application. Our work highlights the potential for BCP amendments to promote the assembly of a healthy soil microbiome by enhancing the abundance of potential biocontrol microbes while reducing plant pathogens species, which may contribute to soil health.