bluuebunny/crossref_metadata_2025_split huggingface dataset:
Method for potential assessment and adaptation for additive manufacturing of conventionally manufactured components
Authors: Siller Nadja , Werner Sebastian , Molina Veronica , Göhlich Dietmar 
Published: August 2023

AbstractThe novelty of additive manufacturing (AM) involves new requirements, restrictions and rules, that are considerably different to those of conventional manufacturing methods. Therefore, designers often lack experience and knowledge about identifying AM-suited components. However, to ensure profitability, it is essential to choose components, that are well suited for additive manufacturing. State-of-the-art user-support methods for identifying AM potential widely focus on either economic potential or manufacturability but fail to address both aspects. While machine learning solutions are considered highly efficient, the assessment outcome lacks process transparency, inhibiting troubleshooting, plausibility checks and problem-oriented considerations. This paper proposes a holistic, yet detailed and transparent approach to identify conventionally manufactured parts for AM from an existing product portfolio, enabling decision-making based on quantifiable results. It combines and advances state-of-the-art methods, considering manufacturability, economic profitability and socio-ecological aspects. Besides evaluating AM potential, the method additionally assesses the components' potential for re-design-based enhancement for AM suitability. Besides understanding product functions and present production processes, users are expected to have a basic understanding of company goals. The approach involves inquiries regarding company- and product-specific priorities, enabling a weighted assessment. The weights are determined based on individual company philosophies regarding AM value propositions such as differing stakeholder interests and priorities. Additionally, the approach allows users to investigate different development goals by weighting opportunistic and restrictive assessment. The method application is demonstrated via an assembly comprising 11 parts in a scenario focusing on serviceability, eventually determining suitability statements.
A database of human predictive patch test data for skin sensitization
Authors: Strickland Judy , Abedini Jaleh , Allen David G. , Gordon John , Hull Victoria , Kleinstreuer Nicole C. , Ko Hon-Sum , Matheson Joanna , Thierse Hermann-Josef , Truax James , Vanselow Jens T. , Herzler Matthias 
Published: August 2023

AbstractCritical to the evaluation of non-animal tests are reference data with which to assess their relevance. Animal data are typically used because they are generally standardized and available. However, when regulatory agencies aim to protect human health, human reference data provide the benefit of not having to account for possible interspecies variability. To support the evaluation of non-animal approaches for skin sensitization assessment, we collected data from 2277 human predictive patch tests (HPPTs), i.e., human repeat insult patch tests and human maximization tests, for skin sensitization from 1555 publications. We recorded protocol elements and positive or negative outcomes, developed a scoring system to evaluate each test for reliability, and calculated traditional and non-traditional dose metrics. We also traced each test result back to its original report to remove duplicates. The resulting database, which contains information for 1366 unique substances, was characterized for physicochemical properties, chemical structure categories, and protein binding mechanisms. This database is publicly available on the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods website and in the Integrated Chemical Environment to serve as a resource for additional evaluation of alternative methods and development of new approach methodologies for skin sensitization assessments.
Phenotype Design Space Provides a Mechanistic Framework Relating Molecular Parameters to Phenotype Diversity Available for Selection
Authors: Savageau Michael A. 
Published: August 2023

AbstractTwo long-standing challenges in theoretical population genetics and evolution are predicting the distribution of phenotype diversity generated by mutation and available for selection, and determining the interaction of mutation, selection and drift to characterize evolutionary equilibria and dynamics. More fundamental for enabling such predictions is the current inability to causally link genotype to phenotype. There are three major mechanistic mappings required for such a linking – genetic sequence to kinetic parameters of the molecular processes, kinetic parameters to biochemical system phenotypes, and biochemical phenotypes to organismal phenotypes. This article introduces a theoretical framework, the Phenotype Design Space (PDS) framework, for addressing these challenges by focusing on the mapping of kinetic parameters to biochemical system phenotypes. It provides a quantitative theory whose key features include (1) a mathematically rigorous definition of phenotype based on biochemical kinetics, (2) enumeration of the full phenotypic repertoire, and (3) functional characterization of each phenotype independent of its context-dependent selection or fitness contributions. This framework is built on Design Space methods that relate system phenotypes to genetically determined parameters and environmentally determined variables. It also has the potential to automate prediction of phenotype-specific mutation rate constants and equilibrium distributions of phenotype diversity in microbial populations undergoing steady-state exponential growth, which provides an ideal reference to which more realistic cases can be compared. Although the framework is quite general and flexible, the details will undoubtedly differ for different functions, organisms and contexts. Here a hypothetical case study involving a small molecular system, a primordial circadian clock, is used to introduce this framework and to illustrate its use in a particular case. The framework is built on fundamental biochemical kinetics. Thus, the foundation is based on linear algebra and reasonable physical assumptions, which provide numerous opportunities for experimental testing and further elaboration to deal with complex multicellular organisms that are currently beyond its scope. The discussion provides a comparison of results from the PDS framework with those from other approaches in theoretical population genetics.
Ultra-long-term results of the Chiari pelvic osteotomy in hip dysplasia patients: a minimum of thirty-five years follow-up
Authors: Chiari Catharina , Schneider Eleonora , Stamm Tanja , Peloschek Philipp , Kotz Rainer , Windhager Reinhard 
Published: August 2023

Abstract
Purpose
The Chiari pelvic osteotomy was the first surgical procedure to address hip dysplasia by changing the position of the acetabulum by medialization, thus creating a bony roof and improving biomechanical conditions. The aim of this retrospective cohort study was to report on the very long-term results of this technique.

Methods
Out of a consecutive series of 1536 hips, 504 in 405 patients were available for follow-up. The patients were assessed by physical and radiological examination. A Kaplan–Meier survival analysis with total hip arthroplasty as an endpoint was performed and stratified for age groups, pre-operative diagnosis, sex and osteoarthritis stage.

Results
The average follow-up was 36 ± 8.1 years (range, 35.2 to 54). The average pain level on the Visual Analogue Scale was 2.9 ± 2.6 (range 0 to 8.7). The average Harris Hip Score was 80.2 ± 17.4 (range 17.4 to 100). Correction of dysplasia was effective and remained stable over time. Osteoarthritis significantly increased over time with 53% Tönnis grade 3 at follow-up. The cumulative survivorship was 79.8% (95% confidence interval (CI), 76.1–83.2%) at 20 years, 57.1% (95% CI, 52.8–61.8%) at 30 years and 35% (95% CI, 30.3–40.3%) at 40 years. Young age, male sex and low osteoarthritis grade were positive prognostic factors.

Conclusions
Although the Chiari pelvic osteotomy is considered a salvage procedure nowadays, it achieved excellent long-term results even in indications, which would be treated differently today. Young patients without osteoarthritis had the best outcome.
Is the Coral Triangle’s future shown in a Pliocene reef gap?
Authors: Harrison G. William M. , Santodomingo Nadia , Johnson Kenneth G. , Renema Willem 
Published: August 2023

AbstractAlthough Pliocene temperature and pCO2 are similar to those predicted in the IPPC RCP4.5 scenario, the distribution of coral reefs in the center of maximum coral diversity, the Coral Triangle, during this period has not been explored. We discovered a significantly lower occurrence of reefs during the Pliocene, which we refer to as the Pliocene Reef Gap, but this decrease was not associated with a drop in coral genus richness. While some of the multiple local causes that drove this decline, such as sea level rise, are analogs to drivers of Anthropocene reef decline, neither warming nor increasing pCO2 are among them.
Generation of a radially polarized beam in a polycrystalline ceramic Yb:Lu2O3 thin-disk laser
Authors: Didychenko Denys , Esser Stefan , Beirow Frieder , Savchenko Anton , Pruss Christof , Graf Thomas , Abdou Ahmed Marwan 
Published: August 2023

AbstractWe report on the generation of a continuous-wave (CW) radially polarized beam with an Yb:Lu2O3polycrystalline ceramic disk in a thin-disk laser (TDL) oscillator. A circular grating-waveguide mirror (CGWM) with a high polarization discrimination given by a reflectivity difference between the two orthogonal polarization states of 44.6% was used as a polarization-selective cavity end-mirror. An output power of 175 W was achieved with an optical efficiency of 39.6%. A high degree of radial polarization of 96.2% and a beam propagation factor ofM2hor. = 2.05 andM2ver. = 2.32 were measured at the maximum output power.
Understanding changes in heat waves, droughts, and compound events in Yangtze River Valley and the corresponding atmospheric circulation patterns
Authors: Qian Zhonghua , Sun Yingxiao , Ma Qianrong , Gu Yu , Feng Taichen , Feng Guolin 
Published: August 2023

AbstractHeat waves, droughts, and compound drought and heat waves (CDHWs) have received extensive attention because of their disastrous impacts on agriculture, ecosystems, human health, and society. Here, we computed the heat wave magnitude index (HWMI), drought magnitude index (DMI), and compound drought and heat wave magnitude index (CDHMI) for Yangtze River Valley (YRV) from July to August during 1961–2022. We compared the large-scale atmospheric circulation characteristics of different extreme events based on these indexes. The results show that the positive center with sink motion in East Asia provides a favorable circulation background for heat wave events. Drought events are mainly affected by the zonal wave train dominated by a significant negative anomaly in Siberia and a high-pressure anomaly upstream, and a anticyclonic water vapor with strong divergence over the Yangtze River basin. During CDHW events, both anomalous systems that affect heat waves and droughts appear and strengthen simultaneously. Specifically, in the middle and upper troposphere, the positive height anomaly center in YRV expands abnormally, and the “+–+” wave train over the northern 50° N region of East Asia becomes more obvious. Therefore, the positive anomaly and water vapor anomaly brought by the two circulation patterns at different latitudes are superimposed over the YRV, leading to severe CDHWs. At the same time, the warm positive eddy center and cold negative eddy center in high latitudes exhibit more stable positive pressure features, which are conducive to the persistent development and strengthening of CDHWs. In addition, the anomalous warm sea surface temperature in western Pacific moderating the favorable circulation patterns may also promote the occurrence of CDHWs in the YRV during the same period.
Perspective: mitochondrial STAT3 in cardioprotection
Authors: Kleinbongard Petra 
Published: August 2023

AbstractActivation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key cardioprotective signal not only in animal studies but also in humans—in animals, STAT3 is causally involved in cardioprotection. In response to late ischemic conditioning, canonical function of STAT3 activation upregulates the expression of cardioprotective and anti-apoptotic proteins. In its non-canonical function, STAT3 is activated during ischemic conditioning and is part of the cardioprotective cytosolic survival activating factor enhancement pathway. Activated STAT3 is imported and localized to the mitochondria. Mitochondrial STAT3 stimulates the activity of mitochondrial electron transport chain complex I, reduces mitochondrial reactive oxygen species production and mitochondrial permeability transition pore opening. Finally, two novel aspects of STAT activation in cardioprotection are discussed: a genetic variance of the STAT encoding region as a potential primordial confounding variable for cardioprotection, and the cardioprotective potential of sodium–glucose cotransporter 2 inhibitors through STAT3 activation.
Risk factors for migraine disease progression: a narrative review for a patient-centered approach
Authors: Lipton Richard B. , Buse Dawn C. , Nahas Stephanie J. , Tietjen Gretchen E. , Martin Vincent T. , Löf Elin , Brevig Thomas , Cady Roger , Diener Hans-Christoph 
Published: August 2023

Abstract
Background
In individuals with migraine, attacks may increase in frequency, severity, or both. Preventing migraine progression has emerged as a treatment goal in headache subspecialty practice, but there may be less awareness in general neurology or primary care settings where most people with migraine who seek treatment consult. Herein, we review the definition of and risk factors for migraine progression and consider strategies that could reduce its risk.

Methods
A group of headache expert healthcare professionals, clinicians, and researchers reviewed published evidence documenting factors associated with increased or decreased rates of migraine progression and established expert opinions for disease management recommendations. Strength of evidence was rated as good, moderate, or based solely on expert opinion, using modified criteria for causation developed by AB Hill.

Results
Migraine progression is commonly operationally defined as the transition from ≤ 15 to ≥ 15 monthly headache days among people with migraine; however, this does not necessarily constitute a fundamental change in migraine biology and other definitions should be considered. Established and theoretical key risk factors for migraine progression were categorized into five domains: migraine disease characteristics, treatment-related factors, comorbidities, lifestyle/exogenous factors, and demographic factors. Within these domains, good evidence supports the following risk factors: poorly optimized acute headache treatment, cutaneous allodynia, acute medication overuse, selected psychiatric symptoms, extra-cephalic chronic pain conditions, metabolism-related comorbidities, sleep disturbances, respiratory conditions, former/current high caffeine intake, physical inactivity, financial constraints, tobacco use, and personal triggers as risk factors. Protective actions that may mitigate migraine progression are sparsely investigated in published literature; our discussion of these factors is primarily based on expert opinion.

Conclusions
Recognizing risk factors for migraine progression will allow healthcare providers to suggest protective actions against migraine progression (Supplementary Fig. 1). Intervention studies are needed to weight the risk factors and test the clinical benefit of hypothesized mitigation strategies that emerge from epidemiological evidence.
Clinical and economic implications of epilepsy management across treatment lines in Spain: a real-life database analysis
Authors: Toledano Rafael , Villanueva Vicente , Toledo Manuel , Sabaniego Joel , Pérez-Domper Paloma 
Published: August 2023

Abstract
Background
Epilepsy is a chronic brain disease characterized by recurrent seizures. We investigated real-world management of epilepsy across treatment lines in Spain, including healthcare resource use (HRU) and associated costs.

Methods
This was a retrospective study of real-life data from epilepsy patients prescribed antiseizure medication (ASM) between January 2016 and December 2021. Patients were grouped according to their line of treatment (1st, 2nd, 3rd and 4th +) during the recruitment period. Demographic and clinical characteristics, comorbidities and concomitant medications were analyzed during the baseline period (6 months before starting treatment line); antiepileptic treatments, concomitant medications, HRU and associated costs were analyzed during follow-up.

Results
The study included 5006 patients. Treatment duration decreased as treatment lines progressed (mean ± SD progression time: 523.2 ± 279.1 days from 1st to 2nd line, 351.6 ± 194.4 days from 2nd to 3rd line; 272.7 ± 139.3 days from 3rd to 4th + line). Significant HRU differences were found with subsequent treatment lines, including an increase in hospital admissions and patients on sick leave. Mean (95% CI) adjusted total costs per patient were €2974/year (2773–3175) in the 1st line and €5735/year (5043–6428) in the 4th + line. There was an increase in adjusted direct and total costs with subsequent treatment lines; the mean difference in total costs between cohorts was €2761 (p < 0.001). The highest direct costs were associated with epilepsy medication, days at the hospital and specialist visits.

Conclusion
Our data revealed a progressive increase in the use of resources and associated costs across subsequent epilepsy treatment lines.
A comparison between real-time intraoperative voice dictation and the operative report in laparoscopic cholecystectomy: a multicenter prospective observational study
Authors: Eryigit Özgür , van de Graaf Floyd W. , Nieuwenhuijs Vincent B. , Sosef Meindert N. , de Graaf Eelco J. R. , Menon Anand G. , Lange Marilyne M. , Lange Johan F. 
Published: August 2023

Abstract
Purpose
The current operative report often inadequately reflects events occurring during laparoscopic cholecystectomy (LC). The addition of intraoperative video recording to the operative report has already proven to add important information. It was hypothesized that real-time intraoperative voice dictation (RIVD) can provide an equal or more complete overview of the operative procedure compared to the narrative operative report (NR) produced postoperatively.

Methods
SONAR is a multicenter prospective observational trial, conducted at four surgical centers in the Netherlands. Elective LCs of patients aged 18 years and older were included. Participating surgeons were requested to dictate the essential steps of LC during surgery. RIVDs and NRs were reviewed according to the stepwise LC guideline of the Dutch Society for Surgery. The cumulative adequacy rates for RIVDs were compared with those of the postoperatively written NR.

Results
79 of 90 cases were eligible for inclusion and available for further analysis. RIVD resulted in a significantly higher adequacy rate compared to NR for the circumferential dissection of the cystic duct and artery (NR 32.5% vs. RIVD 61.0%, P = 0.016). NR had higher adequacy rates in reporting the transection of the cystic duct (NR 100% vs. RIVD 77.9%, P =  < 0.001) and the removal of the gallbladder from the liver bed (NR 98.7% vs. RIVD 68.8%, P < 0.001). The total adequacy was not significantly different between the two reporting methods (NR 78.0% vs. RIVD 76.4%, P = 1.00).

Conclusion
Overall, the adequacy of RIVD is comparable to the postoperatively written NR in reporting surgical steps in LC. However, the most essential surgical step, the circumferential dissection of the cystic duct and artery, was reported more adequately in RIVD.
Aspects of the skin morphology in the sub-Antarctic fur seal Arctocephalus tropicalis
Authors: Bester M. N. , van Ouwerkerk M. 
Published: August 2023

AbstractThe present study examined whether sweat glands are present in the skin of sub-Antarctic fur seals, Arctocephalus tropicalis, using standard histological procedures and light microscopy. Aspects of the microanatomy and histology of skin were described to elucidate structure and function. Sweat glands were present both in the furred areas of the body trunk, as well as in naked skin areas of the flippers. The density of the apocrine sweat glands appeared higher in fur-covered areas than in naked areas, while the size of sweat glands was similar amongst naked and fur-covered skin. The superficial position of sweat glands in the dermis of naked skin areas and the large, coiled, tubular nature of the secretory portion seem to indicate sweat gland activity in contrast to the deep lying, narrow sweat glands in fur-covered areas.
Chronic kidney disease mineral bone disorder in childhood and young adulthood: a ‘growing’ understanding
Authors: Lalayiannis Alexander D. , Soeiro Emilia M. D. , Moysés Rosa M. A. , Shroff Rukshana 
Published: August 2023

AbstractChronic kidney disease (CKD) mineral and bone disorder (MBD) comprises a triad of biochemical abnormalities (of calcium, phosphate, parathyroid hormone and vitamin D), bone abnormalities (turnover, mineralization and growth) and extra-skeletal calcification. Mineral dysregulation leads to bone demineralization causing bone pain and an increased fracture risk compared to healthy peers. Vascular calcification, with hydroxyapatite deposition in the vessel wall, is a part of the CKD-MBD spectrum and, in turn, leads to vascular stiffness, left ventricular hypertrophy and a very high cardiovascular mortality risk. While the growing bone requires calcium, excess calcium can deposit in the vessels, such that the intake of calcium, calcium- containing medications and high calcium dialysate need to be carefully regulated. Normal physiological bone mineralization continues into the third decade of life, many years beyond the rapid growth in childhood and adolescence, implying that skeletal calcium requirements are much higher in younger people compared to the elderly. Much of the research into the link between bone (de)mineralization and vascular calcification in CKD has been performed in older adults and these data must not be extrapolated to children or younger adults. In this article, we explore the physiological changes in bone turnover and mineralization in children and young adults, the pathophysiology of mineral bone disease in CKD and a potential link between bone demineralization and vascular calcification.
Graphical abstract