bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Caenorhabditis elegans in the evaluation of food nutrition: A review
Authors: Li Quancen , Xiao Meifang , Li Na , Cai Wenwen , Zhao Chao , Liu Bin , Zeng Feng 
Published: February 2023

AbstractAt present, more and more people are suffering from various diseases and it is particularly important to find a suitable biological model to evaluate the prevention and treatment effects of various drugs and active ingredients on diseases. In all biological models, Caenorhabditis elegans is a kind of organism that is easy to observe and cultivate, has a clear genetic background and a high degree of signal pathway conservation with humans. A variety of active ingredients such as polyphenols, polysaccharides, polypeptides, and vitamins exist from natural products, which has extremely high physiological functions and medicinal values. It is highly reliable to evaluate the trophic and functional properties of the active ingredients from natural products in C. elegans. The functional properties of the active ingredients from natural products such as antiaging, anti‐oxidation, regulating lipid metabolism, preventing and treating Alzheimer's disease in C. elegans were clarified in this review. At the same time, its possible pathways were summarized. The literature revealed that it had great effect to evaluate the nutrition and functionality of the active ingredients from natural products in C. elegans. Finally, the shortcomings in this field and suggestions for further improvement in this field have been emphasized.
[FeFe] Hydrogenase: 2‐Propanethiolato‐Bridged {FeFe} Systems as Electrocatalysts for Hydrogen Production in Acetonitrile‐Water
Authors: Agarwal Tashika , Kaur‐Ghumaan Sandeep 
Published: February 2023

AbstractDiiron bis(monothiolato)‐bridged hydrogenase mimics [Fe2(μ‐SiPr)2(CO)6] A (iPr=isopropyl) and their phosphine derivatives [Fe2(μ‐SiPr)2(CO)5(L1/2)] and [Fe2(μ‐SiPr)2(CO)4(L3)] {tricyclohexylphosphine (L1, PCy3) 1, triphenylphosphine (L2, PPh3) 2 and cis‐1,2‐bis(diphenylphosphino)ethylene (L3, dppv) 3} have been synthesized and investigated for electrocatalytic proton reduction activity in CH3CN−H2O. Based on the FTIR data (red‐shift), the electron‐donating ability of the phosphines followed the order: dppv>PCy3>PPh3 (average shift value with respect to complex A was 61 (1), 51 (2) and 80 (3) cm−1). From CV measurements, it was seen that the catalytic reduction potential (acetic acid as proton source) shifted considerably towards positive potentials (anodic shift) on changing the solvent from pure CH3CN to CH3CN−H2O (4 : 1 v/v). An increase in the percentage of water in CH3CN led to the decomposition of complexes 1 and 3. Though complexes A and 2 were stable in CH3CN−H2O (3 : 2 v/v), no improvement in electrocatalytic currents was observed.
Influence of Changing the Remote Substituents on Charge Transfer Properties of Cyanide‐Bridged Trinuclear Fe−Ru−Fe Complexes
Authors: Tan Bing‐Chang , Wang Qian , Jiang Long‐Long , Song Ying , Wu Xin‐Tao , Sheng Tian‐Lu 
Published: February 2023

AbstractTo investigate the effect of ligand remote (>10 Å) substituents on the bridging metal center on the metal‐to‐metal charge transfer (MMCT) properties in cyanidometa‐bridged complexes, a series of new cyanidometal‐bridged complexes and their one‐electron and two‐electron oxidation products have been synthesized and well characterized (namely, trans‐[Cp(dppe)Fe−NC−(L)Ru(PPh3)−CN−Fe(dppe)Cp][PF6]n (n=2, 3, 4) (L=dmptpy, 1[PF6]n; L=meoptpy, 2[PF6]n; L=t‐Buptpy, 3[PF6]n) (Cp=1,3‐cyclopentadiene, dppe=1,2‐bis(diphenylphosphino)ethane, PPh3=triphenylphosphine, dmptpy=4′‐(4‐dimethylaminophenyl)‐2,2′,6′,2′′‐terpyridine, meoptpy=4′‐(4‐methoxyphenyl)‐2,2′,6′,2′′‐terpyridine, t‐Buptpy=4′‐(4‐tertbutylphenyl)‐2,2′,6′,2′′‐terpyridine)). The investigations suggest that the cyanido‐stretching (νCN) vibration energy for the complexes is unsensitive to the electron‐donating ability change of the remote substituents of the cyanidometal bridging auxiliary ligand from tertbutyl, methoxy to dimethylamino group. However, the MMCT energies of the one‐ and two‐electron oxidation complexes are still sensitive to the remote substituents of the ligand on the bridging metal center, and decreases with the increase of the electron‐donating ability of the remote substituents from tertbutyl, methoxy to dimethylamino group. All one‐electron and two‐electron oxidation products belong to Class II mixed valence compounds according to the classification of Robin and Day.
Ring‐Expanded N‐Heterocyclic Copper(I) Boryl Complexes: The Structures of [(6‐Dipp)CuBcat], [(6‐Dipp)CuBneop], and [(6‐Dipp)CuBhex]
Authors: Babula Dawid J. , Charman Rex S. C. , Jerome Thomas H. , Horsley Downie Thomas M. , Mahon Mary F. , Liptrot David J. 
Published: February 2023

Abstractσ‐Bond metathesis reactions between [(6‐Dipp)CuOtBu] (6‐Dipp=:C({Dipp}NCH2)2CH2, Dipp=2,6‐iPr2−C6H3) and three diboranes gave access to three new copper(I) boryl complexes [(6‐Dipp)CuBcat], [(6‐Dipp)CuBneop], and [(6‐Dipp)CuBhex] (cat=1,2‐O2C6H4; neop=(OCH2)2C(CH3)2; hex=OC(CH3)HCH2C(CH3)2O). Whilst [(6‐Dipp)CuBcat] and [(6‐Dipp)CuBneop] formed rapidly in toluene, access to [(6‐Dipp)CuBhex] required heating to 60 °C for days. The complexes were characterised by single‐crystal X‐ray crystallography which showed in all three cases that the systems were monomers and distorted‐linear at the copper atom. The stability of [(6‐Dipp)CuBneop] was found to be comparable to that of [(IPr*)Cu‐Bneop] (IPr*=1,3‐bis(2,6‐(diphenylmethyl)‐4‐methylphenyl)imidazol‐2‐ylidene); it persisted in solution for days with no sign of decomposition. [(6‐Dipp)CuBhex] is a rare crystallographically characterised example of a complex containing a boryl anion supported by the hexylene glycolato ligand.
Electrochemically Generated Copper(I)‐Catalyzed Click Chemistry: Triazole Synthesis and Insights into Their Photophysical Properties
Authors: Krishnan Murugan , Kathiresan Murugavel , Praveen Chandrasekar 
Published: February 2023

AbstractHerein, we report the electro‐click (e‐CLICK) reaction via electrochemically generated copper(I) catalytic species. The reaction worked under constant potential electrolysis (−0.25 V) with copper(II) nitrate and 2,2′‐bipyridine serving as pre‐catalyst and ligand respectively. The reaction accommodates electronically different organic azides and terminal alkynes to afford 1,2,3‐triazoles in good synthetic yields with excellent 1,4‐regioselectivity. Compared to traditional click chemistry, the developed e‐CLICK methodology avoids the use of external reducing agents such as sodium ascorbate. Absorptive properties of selected triazole products were assessed by UV‐visible electronic spectra. Triazole (3 e) was further applied for the spectrophotometric detection of Co2+ and Cu2+ species.
Umbrella review: Summary of findings for acupuncture as treatment for radiation‐induced xerostomia
Authors: Dörfler Jennifer , Freuding Maren , Zaiser Christopher , Büntzel Jens , Keinki Christian , Käsmann Lukas , Hübner Jutta 
Published: February 2023

AbstractAcupuncture is a common part of complementary medicine. However, traditional Chinese acupuncture has been built on concepts which are not in accordance with science‐based medicine. Our aim was to critically assess the evidence presented in systematic reviews (SRs) and meta‐analyses (MAs) about the effectiveness of acupuncture on radiotherapy induced xerostomia. A systematic search was conducted in February 2022. We evaluated all SRs/MAs using the AMSTAR‐2 instrument. Eight SRs, with 12 controlled studies were included. All SRs summarize that the methodological drawbacks do not allow to give a clear statement about the effectiveness of acupuncture. While objective assessments in most SRs/MAs reported no difference between real and sham acupuncture, some favorable effects on subjective xerostomia symptoms are found. No clinical meaningful effectiveness of acupuncture on xerostomia has been proven so far, but positive subjective findings need to be explored more. While most SRs recommend further studies, studies involving patients with a serious cancer diagnosis are ethically questionable.
The role of radiomics in tongue cancer: A new tool for prognosis prediction
Authors: Mossinelli Chiara , Tagliabue Marta , Ruju Francesca , Cammarata Giulio , Volpe Stefania , Raimondi Sara , Zaffaroni Mattia , Isaksson Johannes Lars , Garibaldi Cristina , Cremonesi Marta , Corso Federica , Gaeta Aurora , Emili Ilaria , Zorzi Stefano , Alterio Daniela , Marvaso Giulia , Pepa Matteo , De Fiori Elvio , Maffini Fausto , Preda Lorenzo , Benazzo Marco , Jereczek‐Fossa Barbara Alicja , Ansarin Mohssen 
Published: February 2023

AbstractBackgroundRadiomics represents an emerging field of precision‐medicine. Its application in head and neck is still at the beginning.MethodsRetrospective study about magnetic resonance imaging (MRI) based radiomics in oral tongue squamous cell carcinoma (OTSCC) surgically treated (2010–2019; 79 patients). All preoperative MRIs include different sequences (T1, T2, DWI, ADC). Tumor volume was manually segmented and exported to radiomic‐software, to perform feature extraction. Statistically significant variables were included in multivariable analysis and related to survival endpoints. Predictive models were elaborated (clinical, radiomic, clinical‐radiomic models) and compared using C‐index.ResultsIn almost all clinical‐radiomic models radiomic‐score maintained statistical significance. In all cases C‐index was higher in clinical‐radiomic models than in clinical ones. ADC provided the best fit to the models (C‐index 0.98, 0.86, 0.84 in loco‐regional recurrence, cause‐specific mortality, overall survival, respectively).ConclusionMRI‐based radiomics in OTSCC represents a promising noninvasive method of precision medicine, improving prognosis prediction before surgery.
Fiscal targets. A guide to forecasters?
Authors: Paredes Joan , Pérez Javier J. , Perez Quiros Gabriel 
Published: February 2023

SummaryWe formulate and estimate empirical models for a selection of EU countries (Germany, France, Italy, Spain, Portugal, and Ireland) to show that ex‐ante government (consumption) targets convey useful information about ex‐post fiscal developments, even if the track record of governments meeting their respective targets is low. The use of targets is particularly valuable when there is limited information about its implementation, for example, at the beginning of a fiscal year, when observed data are scarce. Thus, forecasters would be well advised to use fiscal targets as a guide in creating projections, despite the findings of a well‐established literature that reports that, ex post, governments tend to induce politically motivated biases in policy targets.
Trabecular Bone Score (TBS) Varies with Correction for Tissue Thickness Versus Body Mass Index: Implications When Using Pediatric Reference Norms
Authors: Valenzuela Riveros Luisa F , Long Jin , Bachrach Laura K , Leonard Mary B , Kent Kyla 
Published: February 2023

ABSTRACT
Trabecular bone score (TBS) derived from secondary analysis of lumbar spine dual-energy X-ray absorptiometry (DXA) scans improves fracture prediction independent of bone mineral density (BMD) in adults. The utility of TBS to assess fracture risk in younger patients has not been established because pediatric norms have been lacking. Robust TBS reference data from the Bone Mineral Density in Childhood Study (BMDCS) have been published. TBS values for the BMDCS study were derived using an algorithm that accounts for tissue thickness (TBSTH) rather than the commercially available algorithm that adjusts for body mass index (BMI; TBSBMI). We examined the magnitude of differences in TBSTH and TBSBMI in a cohort of 189 healthy youth. TBS values using both algorithms increased with age and pubertal development in a similar pattern. However, TBSBMI values were systematically and significantly higher than TBSTH (mean = 0.06, p &lt; 0.0001). The difference between calculated TBSBMI and TBSTH was not uniform. Differences were greater at lower TBS values, in males, in older individuals, in those at later Tanner stages, and in those with a greater BMI Z-score. These systematic differences preclude the development of a simple formula to allow conversion of TBSBMI to TBSTH “equivalents.” Because of these systematic differences in these two algorithms, using an individual's TBSBMI to calculate a Z-score using the BMDCS TBSTH reference values results in a falsely higher TBS Z-score (differences mean = 0.73, interquartile range [IQR] = 0.3 to 1.6). Until TBSTH software for Hologic DXA equipment becomes commercially available, BMDCS TBS reference norms should not be used. © 2023 American Society for Bone and Mineral Research (ASBMR).
Role of the Mitochondrial Permeability Transition in Bone Metabolism and Aging
Authors: Sautchuk Rubens , Yu Chen , McArthur Matthew , Massie Christine , Brookes Paul S. , Porter George A. , Awad Hani , Eliseev Roman A. 
Published: February 2023

ABSTRACT
The mitochondrial permeability transition pore (MPTP) and its positive regulator, cyclophilin D (CypD), play important pathophysiological roles in aging. In bone tissue, higher CypD expression and pore activity are found in aging; however, a causal relationship between CypD/MPTP and bone degeneration needs to be established. We previously reported that CypD expression and MPTP activity are downregulated during osteoblast (OB) differentiation and that manipulations in CypD expression affect OB differentiation and function. Using a newly developed OB-specific CypD/MPTP gain-of-function (GOF) mouse model, we here present evidence that overexpression of a constitutively active K166Q mutant of CypD (caCypD) impairs OB energy metabolism and function, and bone morphological and biomechanical parameters. Specifically, in a spatial-dependent and sex-dependent manner, OB-specific CypD GOF led to a decrease in oxidative phosphorylation (OxPhos) levels, higher oxidative stress, and general metabolic adaptations coincident with the decreased bone organic matrix content in long bones. Interestingly, accelerated bone degeneration was present in vertebral bones regardless of sex. Overall, our work confirms CypD/MPTP overactivation as an important pathophysiological mechanism leading to bone degeneration and fragility in aging. © 2023 American Society for Bone and Mineral Research (ASBMR).
CEO's characteristics and value creation from corporate spin‐offs
Authors: Kim Soohyung , Yoon Yeosong 
Published: February 2023

AbstractAn important corporate spin‐off procedure is forming the spun‐off unit's management team by a parent firm, especially the selection of the spun‐off unit CEO. Using 207 completed spin‐offs with announcement and execution dates between 1994 and 2018, we investigate whether the financial expertise of spun‐off unit CEOs is an essential determinant of post‐spin‐off performance other than spun‐off unit CEOs’ other observable characteristics, including their general managerial skills. We find that the abnormal announcement returns for appointing financial expert CEOs at spun‐off units are between 2.83 and 3.14 percentage points larger than those generated for appointing non‐financial expert CEOs. Furthermore, spun‐off unit CEOs with financial expertise significantly improve spin‐off firms’ access to external capital resources and subsequent operating performance. Overall, we conclude that spun‐off unit CEOs’ financial expertise is a critical determinant of the value creation of spin‐off procedures. Our paper contributes to a growing literature on CEOs, their characteristics, and their impact on firm performance.
Genetically engineered mouse models of FK506‐binding protein 5
Authors: Gebru Niat T. , Hill Shannon E. , Blair Laura J. 
Published: February 2023

AbstractFK506 binding protein 51 (FKBP51) is a molecular chaperone that influences stress response. In addition to having an integral role in the regulation of steroid hormone receptors, including glucocorticoid receptor, FKBP51 has been linked with several biological processes including metabolism and neuronal health. Genetic and epigenetic alterations in the gene that encodes FKBP51, FKBP5, are associated with increased susceptibility to multiple neuropsychiatric disorders, which has fueled much of the research on this protein. Because of the complexity of these processes, animal models have been important in understanding the role of FKBP51. This review examines each of the current mouse models of FKBP5, which include whole animal knockout, conditional knockout, overexpression, and humanized mouse models. The generation of each model and observational details are discussed, including behavioral phenotypes, molecular changes, and electrophysiological alterations basally and following various challenges. While much has been learned through these models, there are still many aspects of FKBP51 biology that remain opaque and future studies are needed to help illuminate these current gaps in knowledge. Overall, FKBP5 continues to be an exciting potential target for stress‐related disorders.
Time of acquisition and high spatial resolution mass spectrometry imaging
Authors: Wang Mary F. , Joignant Alena N. , Sohn Alexandria L. , Garrard Kenneth P. , Muddiman David C. 
Published: February 2023

AbstractThe field of mass spectrometry imaging (MSI) is constantly evolving to analyze a diverse array of biological systems. A common goal is the need to resolve cellular and subcellular heterogeneity with high spatial resolution. As the field continues to progress towards high spatial resolution, other parameters must be considered when developing a practical method. Here, we discuss the impacts of high spatial resolution on the time of acquisition and the associated implications they have on an MSI analysis (e.g., area of the region of interest). This work presents a brief tutorial serving to evaluate high spatial resolution MSI relative to time of acquisition and data file size.
Dermatitis neglecta of the vulva
Authors: Granahan Aoife , Fadlelseed Huda , Nolan Niamh , O'Brien Donal , Lally Aoife 
Published: February 2023

AbstractDermatitis neglecta (DN) is a condition that arises secondary to inadequate cleansing and self‐neglect leading to the accumulation of epidermal debris, corneocytes and sebum. Rarely reported, it is often diagnostically challenging and can mimic other pathologies. It typically arises in cases of chronic disability or psychiatric illness. We present the case of a 72‐year‐old lady with extensive hyperkeratotic plaques of the vulva. Initial clinical impression was that of a malignant or infectious process and skin biopsies were performed. However, with intensive topical care and education, complete resolution was achieved. Frequent relapses of vulval DN occurred over the subsequent months, where secondary gain was identified with increased care and attention from family and friends.
Impact of ecological restoration on ecosystem service trade‐offs: Insight from karst desertification control
Authors: Zhang Shihao , Xiong Kangning , Deng Xuehua , Kong Lingwei , Min Xiaoying 
Published: February 2023

AbstractEcological restoration programmes (ERP) contribute to greening and regulation service improvement. However, whether greening exacerbates the social‐ecosystem trade‐offs in a degraded ecoregion remains unclear. In this study, we chose South China karst, a global hotspot of greening (improvement of vegetation), as a case‐study. First, we analyzed the degree of greening in different ecoregions and the contribution of landscape to greening during 2000–2020. Second, we investigated the relationship between greening and indicators (land use, gross domestic product [GDP], and population distribution) and explored the relationship between regulation and provision over time. The results showed that the degree of greening in different ecoregions was different, although ERP played a positive role in greening. The rapid greening in degraded ecoregion was relevant to net forest expansion (26.79% of the conversion area), while the slow greening in a non‐degraded ecoregion was associated with net built‐up land expansion (25.81% of the conversion area). Forest expansion in a degraded ecoregion increased out‐migration and exacerbated the trade‐off between greening and GDP reduction, regulation and provision. Our study found that weak service supply in degraded ecoregion limited farming income, which forced farmers to migrate for work and abandon slopeland. In conclusion, the combination of retiring land and emigrating for work triggers land functional transformation and aggravates social‐ecosystem trade‐offs, but agroforestry can mitigate these trade‐offs. Despite there are limitations in the quantification of population migration, it still provides new insight for the next stage of ERP.
Plan S and purpose: The future direction for UK learned societies
Authors: Treadway Jon , Greaves Sarah 
Published: February 2023

Key points
A group of UK‐based learned societies were anonymously interviewed to understand how trends are affecting their missions, strategies, and operations.
The societies' missions focus on supporting academics and disseminating knowledge, with publishing being a means to achieve those goals rather than an end in itself.
The responses were concerned about addressing open access (OA) but, particularly in the post‐COVID‐19 era, this was not necessarily their highest priority.
The societies expressed reliance on larger corporate publishers on them to navigate the transition to OA publishing.
The societies' focus is on evolving their missions to meet the changing needs of their academic communities, with issues around premises as a result of COVID‐19 being more pressing than publishing industry changes.
The societies face challenges in adapting to the shift to online and digital operations, particularly in regards to maintaining engagement with their members.
University press publishing and the ecology of disciplinary fluidity: General observations
Authors: Hérubel Jean‐Pierre V. M. 
Published: February 2023

AbstractAcademic book and journal publishing constitutes the majority focus of university presses. Besides commercial scholarly publishers, academic scholars and researchers view the opportunities provided by university presses as important venues for the dissemination of their research. This discussion focuses on the disciplinary imperative to publish scholarship that is ever more fluid and specialized as academic disciplines continue to become further nuanced in their response to the increasing knowledge produced by humanities and social science inquiry. The focus is on university presses and not commercial scholarly presses, although constitute a significant locus of scholarly publishing. What are the general characteristics of academic specialization and university press publishing? Further, how is disciplinary fluidity, especially evolving specialization, reflected in university press book publishing nomenclature and how scholarship is tied to the intellectual preoccupations of academic specialization? Multi‐ and inter‐disciplinarities further articulate disciplinary publishing, accelerating disciplinary fluidity. Examples from disciplinary and emerging configurations of disciplinary nomenclature utilized by university presses offers insight into specialization and publishing. Academic history publishing is used to illustrate newly emerging fluid disciplinary configurations.