bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular determinants of neurocognitive deficits in glioma: based on 2021 WHO classification
Authors: Zhang Kun , Yang Tianrui , Xia Yu , Guo Xiaopeng , Chen Wenlin , Wang Lijun , Li Junlin , Wu Jiaming , Xiao Zhiyuan , Zhang Xin , Jiang Wenwen , Xu Dongrui , Guo Siying , Wang Yaning , Shi Yixin , Liu Delin , Li Yilin , Wang Yuekun , Xing Hao , Liang Tingyu , Niu Pei , Wang Hai , Liu Qianshu , Jin Shanmu , Qu Tian , Li Huanzhang , Zhang Yi , Ma Wenbin , Wang Yu 
Published: March 2023

Abstract
Purpose
Cognitive impairment is a common feature among patients with diffuse glioma. This study aimed to investigate the relationship between cognitive function and clinical and molecular factors under the new 2021 WHO classification of tumors of the central nervous system (CNS 5).
Methods
A total of 110 patients with diffuse glioma were enrolled and underwent preoperative cognitive assessments using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Clinical information was collected from medical records, and gene sequencing was performed to analyze 18 most influenced gene alterations. The differences in cognitive function between patients with and without glioblastoma were compared under both CNS 4 and CNS 5 to assess the effect of differentiation on cognition.
Results
The study found that age, tumor location, and glioblastoma had significant differences on cognitive function. Several genetic alterations were significantly correlated with cognition. For most focused genes, patients with a low number of genetic alterations tended to have better cognitive function.
Conclusion
Our study suggested that, in addition to general clinical characteristics such as age, histological type and tumor location, the molecular characteristics of glioma play a crucial role in cognitive function. Further research into the mechanisms by which tumors affect brain function is expected to enhance the quality of life for glioma patients. The findings of this study highlight the importance of considering both clinical and molecular factors in the management of glioma patients to improve cognitive outcomes.
Primary or metastatic branchial cleft carcinoma?: A case report
Authors: Ma Yang , Liu Hangyu , Yang Lijing , Tang Shijie , Shi Lungang 
Published: March 2023

Abstract
The brachial cleft carcinoma is an extremely rare head and neck facial malignancy, and there is some disagreement about its differential diagnosis. In this paper, we report a 63-year-old male patient who had a mass on the left side of the neck and diagnosed as the brachial cleft carcinoma by intraoperative biopsy pathology. However, this patient was diagnosed with the carcinoma of the left soft palate more than 20 days after surgery and esophageal cancer 2 years later, and was treated accordingly. Therefore, it is hard to confirm whether the branchial cleft carcinoma is primary or metastatic. In fact, the diagnostic criteria for primary squamous cell carcinoma of branchial cleft cysts are very rigorous. Confirmation of the diagnosis is based on pathological examination of the branchial cleft cyst epithelium lined with squamous cells, meanwhile, a thorough examination should also be performed to exclude the presence of other primary cancers.
Apatite trace element composition as an indicator of ore deposit types: A machine learning approach
Authors: Qiu Kun-Feng , Zhou Tong , Chew David , Hou Zhao-Liang , Müller Axel , Yu Hao-Cheng , Lee Robert G. , Chen Huan , Deng Jun 
Published: March 2023

Abstract
The diverse suite of trace elements incorporated into apatite in ore-forming systems has important applications in petrogenesis studies of mineral deposits. Trace element variations in apatite can be used to distinguish between fertile and barren environments, and thus have potential as mineral exploration tools. Such classification approaches commonly employ two-variable scatterplots of apatite trace element compositional data. While such diagrams offer accessible visualization of compositional trends, they often struggle to effectively distinguish ore deposit types because they do not employ all the high-dimensional (i.e., multi-element) information accessible from high-quality apatite trace element analysis. To address this issue, we use a supervised machine-learning-based approach (eXtreme Gradient Boosting, XGBoost) to correlate apatite compositions with ore deposit type, utilizing such high-dimensional information. We evaluated 8629 apatite trace element data from five ore deposit types (porphyry, skarn, orogenic Au, iron oxide copper gold, and iron oxide-apatite) along with unmineralized magmatic and metamorphic apatite to identify discriminating parameters for the individual deposit types, as well as for mineralized systems. According to feature selection, eight elements (Th, U, Sr, Eu, Dy, Y, Nd, and La) improve the model performance. We show that the XGBoost classifier efficiently and accurately classifies high-dimensional apatite trace element data according to the ore deposit type (overall accuracy: 94% and F1 score: 89%). Interpretation of the model using the SHAPley Additive exPlanations (SHAP) tool shows that Th, U, Eu, and Nd are the most indicative elements for classifying deposit types using apatite trace element chemistry. Our approach has broad implications for the better understanding of the sources, chemistry, and evolution of melts and hydrothermal fluids resulting in ore deposit formation.
Distribution characteristics and influencing factors of water resources in Henan Province
Authors: Zhou Yishuang , Tong Xiaoxia , Gan Rong , Liu Panfeng , Guo Lin , Zhao Shanshan 
Published: March 2023

Abstract
A clear understanding of the spatial and temporal distribution characteristics of water resources is essential for the optimal allocation and sustainable utilization of water resources. In this paper, the spatial and temporal distribution characteristics of water resources in Henan Province were studied based on GIS, combining the Mann-Kendall (M-K) nonparametric test and rescaled range (R/S) analysis. In addition, SPSS software was used to analyze the influence of climate and land use type on water resources. The results indicated that (1) the hot spots of water resources were concentrated in the southwest, while the low values were concentrated in the northeast, and the distribution of water resources decreased from southwest to northeast. (2) In the past 21 years, spatiotemporal mutations in the water resource sequence occurred between 2010 and 2014. The Z-values of the M-K trend test were all less than 0, the H-values of groundwater resources (GWRs) were mostly greater than 0.5, and the h-values of surface water resources (SWRs) and total water resources (TWRs) were less than 0.5, showing an overall declining trend. However, this trend may change in the future. (3) From the correlation analysis, climate change had a greater impact on water resources than land use changes did.
Recycled water for non-potable use: Understanding community perceptions and acceptance in Malaysia
Authors: Bachi' Nur Aina , Wan Mohtar Wan Hanna Melini , Zin Wan Zawiah Wan , Takeuchi Haruka , Hanafiah Zarimah Mohd 
Published: March 2023

Abstract
Sustainable water supply is one of the key issues for water resources management. The future demand for clean water is putting pressure on the Malaysian government to find alternative supplies and best management practices in managing water resources, such as the use of reclaimed water. This paper evaluates the perceptions and acceptance of the use of treated water for non-drinking purposes in Malaysia from the responses of 1,004 participants. The results show that age and level of education play an important role in the level of community acceptance. Females tend to be more selective than males in their acceptance to use reclaimed water. To guarantee that the public receives accurate information about reclaimed water, social media can be used for disseminating information, especially to younger generations.
The practice of integrated asset management in Ugandan small towns
Authors: Musiimenta Bruno Emmanuel , Tutusaus Mireia , Schwartz Klaas 
Published: March 2023

Abstract
Integrated asset management (IAM) has been promoted by international agencies and academics as a promising approach for water utilities in developing countries. These IAM frameworks present logical and linear approaches to managing a utility's infrastructure. In this article, we contrast these frameworks with the everyday practice of asset management in seven small towns in rural Uganda. In rural areas of Uganda, utility managers operating and managing assets need to maneuver between political demands, demands from the Head Office, inadequate resources, and limited capacity. As a result, the practice of asset management necessarily deviates considerably from the logical steps identified in many IAM frameworks. Without diminishing the relevance of the more conceptual IAM frameworks, the article suggests that for IAM to become more impactful for practitioners in rural areas and small towns in developing countries, these contextual factors need to be taken into account.
Impact of COVID-19 Vaccination on the Trend of Hospital Admission and
Mortality in Two Tertiary Care Hospitals in the United Arab Emirates: A
Retrospective Study
Authors: Pradhan Rohit , Ahmed Luai A. , Al Kaabi Nawal , El Subki Waddah Ibrahim , Zaabi Ashraf Al 
Published: March 2023

Objectives:
To investigate the impact of COVID-19 vaccines in the United Arab Emirates (UAE) on the trend of COVID-19-related hospitalization, intensive care unit (ICU) admissions, and case fatality rate (CFR), this retrospective chart review was conducted.

Methods:
We included patients admitted to two tertiary hospitals from October 2020 to July 2022. Patients were categorized into non-vaccinated, partially-vaccinated, and fully-vaccinated groups.

Results:
A total of 2277 cases were included, with 27.49% being non-vaccinated. The monthly trend of admitted patients dropped from 1264 (56.50%) cases in the first half of 2021 to 194 (8.67%) cases in the first half of 2022, with a reduction rate of 84.65%. The trend of ICU admission followed the overall hospital admission rate, with an overall CFR of 0.88%, 95% CI (0.54% to 1.35%), and a virulence rate of 1.76%, 95% CI (1.26% to 2.38%). The incidence of ICU admission in the unvaccinated group was 4.79%, compared to 0% and 0.97% in the partially-vaccinated and fully-vaccinated groups, respectively (p <0.001). The CFR was significantly (p <0.001) higher in the unvaccinated group 2.88%, 95% CI (1.71 to 4.51) than in the partially-vaccinated 0%, 95% CI (0% to 0.59%) and fully-vaccinated groups 0.19%, 95% CI (0.02% to 0.70%).

Conclusion:
Among the study population, COVID-19 vaccines showed promising efficacy in reducing the trend of COVID-19-related hospitalization, ICU admission, and mortality. Full vaccination might reduce the burden of COVID-19 on healthcare.
Antimicrobial Peptides: A Promising Strategy for Anti-tuberculosis
Therapeutics
Authors: Ning Yu , Wang Lujuan , Wang Menglu , Meng Xiangying , Qiao Jinjuan 
Published: March 2023

Abstract:
The high global burden of tuberculosis (TB) and the increasing emergence of the drugresistant
(DR) strain of Mycobacterium tuberculosis (Mtb) emphasize the urgent need for novel antimycobacterial
agents. Antimicrobial peptides (AMPs) are small peptides widely existing in a variety
of organisms and usually have amphiphilic cationic structures, which have a selective affinity to the
negatively charged bacterial cell wall. Besides direct bactericidal mechanisms, including interacting
with the bacterial cell membrane and interfering with the biosynthesis of the cell wall, DNA, or
protein, some AMPs are involved in the host's innate immunity. AMPs are promising alternative or
complementary agents for the treatment of DR-TB, given their various antibacterial mechanisms and
low cytotoxicity. A large number of AMPs, synthetic or natural, from human to bacteriophage
sources, have displayed potent anti-mycobacterial activity in vitro and in vivo. In this review, we
summarized the features, antimycobacterial activity, and mechanisms of action of the AMPs according
to their sources. Although AMPs have not yet met the expectations for clinical application due to their
low bioavailabilities, high cost, and difficulties in large-scale production, their potent
antimycobacterial activity and action mechanisms, which are different from conventional antibiotics,
make them promising antibacterial agents against DR-Mtb in the future.
A Review on the Determination of Biogenic Amines in Fresh and Processed
Fish Products using HPLC, LC-MS/MS and Other Chromatographic
Methods
Authors: Ahangari Hossein , Tavassoli Milad , Khezerlou Arezou , Kiani Salmi Narges , Ehsani Ali , Afshar Mogaddam Mohammad Reza 
Published: March 2023

Abstract:
Biogenic amines (BAs) are compounds deemed to be foodstuff contaminants and are the
cause of poisoning or allergy. The main BAs found in foods include histamine, tyramine, putrescine,
cadaverine, spermine and spermidine. The number of poisoning cases related to BAs in food
has increased, which is reinforcing the need for BAs detection to ensure food safety. BAs are found
in varying quantities in different foods such as fish, fruits, meat, cheese, vegetables, beer, and
wine. Currently, different analytical techniques are used for BAs detection, as well as sample
treatment methods that allow greater sensitivity, higher analyzing speed and lower detection limits.
Moreover, BAs can be precursors of nitrosamines, which have been associated with mutagenic and
carcinogenic activity. This review aims to provide a general approach to the different detection
techniques of the BAs in foods, their concentrations and treatment methods.
Ionizing Radiation: Chemical Kinetics, Chemical Bounds, and Radiation
Chemistry on Polymers
Authors: Ortega Pijeira Martha Sahylí , Magne Tais Monteiro , da Silva Natália Cristina Gomes , Ramos Ribeiro Elisabete Regina Fernandes , Albuquerque Silva Yuri José , Ricci-Junior Eduardo , Rebelo Alencar Luciana Magalhães , Santos-Oliveira Ralph 
Published: March 2023

Abstract:
Ionizing radiation has been used for decades and expanded to several applications in multivariate sectors, becoming an important tool to promote controlled chemical reactions in poly-meric structures, according to their chemical properties for developing new materials. In addition, the use of radiation can also be applied in order to reduce or eliminate compounds from solutions that may be harmful or of low interest. In this review, we overviewed the chemistry behind material irradiation and the attractive use of ionizing radiation in scientific and industrial development. In this regard, the review was divided into three main sections titled (1) chemical kinetics intermediat-ed by radiation, (2) chemical bonds intermediated by radiation, and (3) radiation chemistry on pol-ymers. We concluded that graft polymerization, crosslinking and chain scission reactions induced by ionizing radiation are very efficient and green strategies for developing new materials with im-proved properties. Furthermore, water radiolysis plays a key role in the degradation of several con-taminants, including pharmaceuticals and microplastics, in aqueous solutions. However, more stud-ies must be conducted to complement the existing theory about the proposed mechanisms responsi-ble for modifying the chemical, mechanical, thermal, optical, and so forth properties of irradiated materials.
The Association between COVID-19 and Reactive Arthritis: A Systematic Review of Case Reports and Case Series
Authors: Namakin Kosar , Sadeghzadeh Sara , Tamimi Atena , Abdolzadeh Ayfar , Khanjani Zahra , Ebrahimi Navid , Abdolmohammadi Golara , Golshan Ahmadreza , Fardoost Shakiba , Masrouri Soroush , Hajikhani Bahareh , Salimi Chirani Alireza , Zangiabadian Moein , Javad Nasiri Mohammad 
Published: March 2023

Introduction:Reactive arthritis (ReA) is a joint inflammation that follows an infection at a distant site, often in the gastrointestinal or urogenital tract. Since the emergence of COVID-19 in January 2020, several case reports have suggested a relation between reactive arthritis and severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), due to the novelty of the disease, most findings were reported in the form of case reports or case series, and a comprehensive overview is still lacking.Methods:We searched PubMed/Medline and Embase to identify studies addressing the association between ReA and COVID-19. The following terms were used: (“Reactive Arthritis” OR “Post-Infectious Arthritis” OR “Post Infectious Arthritis”) AND (“COVID-19” OR “SARS-CoV-2” OR “2019-nCoV”).Results:A total number of 35 reports published up to February 16th, 2022, were included in this study. A wide range of ages was affected (mean 41.0, min 4 max 78), with a higher prevalence of males (61.0%) from 16 countries. The number and location of the affected joints were different in included patients, with a higher prevalence of polyarthritis in 41.5% of all cases. Cutaneous mani-festations and visual impairments were found as the most common associated symptoms. Most pa-tients (95.1%) recovered, with a mean recovery time of 24 days. Moreover, arthritis induced by COVID-19 seems to relieve faster than ReA, followed by other infections.Conclusion:ReA can be a possible sequel of COVID-19 infection. Since musculoskeletal pain is a frequent symptom of COVID-19, ReA with rapid onset can easily be misdiagnosed. Therefore, cli-nicians should consider ReA a vital differential diagnosis in patients with post-COVID-19 joint swelling. Additional studies are required for further analysis and to corroborate these findings.
Stability Study and Simultaneous Determination of Norepinephrine, Moxifloxacin,
and Piperacillin + Tazobactam Mixtures Applied in Intensive
Care Medicine
Authors: Schmidt Jéssica Pires , Steppe Martin 
Published: March 2023

Background:
In intensive care units intravenous medicine may be used in simultaneous
infusion in the same intravenous site. Sometimes, the physical compatibility and stability of
the combined solutions are unknown.

Objective:
The objective was to develop, optimize and validate a simple, fast and sensitive stability-
indicating high-performance liquid chromatography (HPLC) for simultaneous quantification
of binary mixtures of norepinephrine, piperacillin + tazobactam, moxifloxacin for intravenous
(IV) administration in different diluents and physical compatibility with mannitol.

Methods:
The HPLC method was performed on a C18LUNA (4.6x250 mm 5-Micron) column,
using acetonitrile: methanol: phosphate buffer pH 3.0 (20:30:50) as eluent and validated according
to ICH guidelines and applied to mixtures of norepinephrine, moxifloxacin, piperacillin, tazobactam
and mannitol at 0, 2, 6, 9 and 24 h. The substances and their mixtures were also evaluated
by visual inspection and pH over time.

Results:
The analytical method developed was specific, linear, precise, accurate and robust. No
visual changes were observed in the mixtures over time, maintaining the pH values (except for
piperacillin + tazobactam which changed 0.5 in 24 h) and losses of less than 10% of content over
the 24 h under analyzed conditions.

Conclusion:
The proposed method is suitable for simultaneous analysis of norepinephrine, moxifloxacin,
piperacillin and tazobactam. All tested mixtures were compatible and stable for up to
24h, which is an important result for increasing patient safety in clinical practice since it has not
been reported in the literature yet. The method can be further investigated and used for different
concentration and diluent combinations.
RADA-16-based Self-assembled Peptide Nanofiber Scaffolds Loaded with
TGF-β1 Enhance the Chondrogenic Differentiation Potential of BMSCs In
vitro
Authors: Yu Peng , Duan Lian , Yan Zhen , Li Jun , Cai Dao-Zhang 
Published: March 2023

Objective:
At present, cartilage repair does not offer ideal efficacy. Fortunately, recent studies
have claimed that RADA-16 peptide is an attractive therapeutic strategy for repairing cartilage defects.
Therefore, this study tried to explore the effect of RADA-16 loaded with transforming growth factor-beta
(TGF-β) 1 on cartilage differentiation of bone marrow mesenchymal stem cells (BMSCs).

Methods:
First, the RADA-16 peptide was synthesized by solid phase peptide, and a well-defined hydrogel
was formed by supramolecular peptide self-assembly. Then, TGF-β1 (loading concentration of 10
ng/mL) was loaded into RADA-16, with scanning electron microscopy to observe the morphology of the
TGF-β1/RADA-16 hydrogel and detect its related properties. Next, BMSCs were isolated from bone marrow
samples and identified. TGF-β1/RADA-16 was co-cultured with L929, BMSCs, and C28/I2 cells,
respectively, and the survival and proliferation ability of the cells was determined by live/dead cell staining
and MTT assay. Chondrogenic differentiation and sGAG production of BMSCs were determined by
Alcian blue staining and Blyscan assay, the expression of cartilage-associated genes by qRT-PCR, and the
levels of inflammatory factors by ELISA. As for mechanism investigation, the Smad and ERK/MAPK
signaling pathways were detected by western blot.

Results:
RADA-16 hydrogel exhibited a well-distributed and interconnected porous surface structure,
with a loading rate of 91.9% for TGF-β1. The TGF-β1/RADA-16 hydrogel had good release and degradation
properties, and had no negative effect on the survival and proliferation ability of BMSCs, L929, and
C28/I2 cells. Importantly, TGF-β1/RADA-16 hydrogel significantly accelerated chondrogenic differentiation
and sGAG generation in BMSCs, and decreased pro-inflammatory factor production. In addition, the
hydrogel also significantly activated the Smad and ERK/MAPK pathways of BMSCs.

Conclusion:
RADA-16 loaded with TGF-β1 has good biological properties and can enhance the chondrogenic
differentiation ability of BMSCs.