bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Supporting Evidence of Medical Cannabis Claims Made on Clinic Websites: Cross-Sectional Study
Authors: O'Neill Braden , Ferguson Jacob , Dalueg Lauren , Yusuf Abban , Kirubarajan Abirami , Lloyd Taryn , Mollanji Eisi , Persaud Navindra 
Published: June 2023

Background
Since the legalization of medical cannabis in Canada in 2013, prescription of cannabis for medical purposes has become commonplace and a multibillion dollar industry has formed. Much of the media coverage surrounding medical cannabis has been positive in nature, leading to Canadians potentially underestimating the adverse effects of medical cannabis use. In recent years, there has been a large increase in clinic websites advertising the use of medical cannabis for health indications. However, little is known about the quality of the evidence used by these clinic websites to describe the effectiveness of cannabis used for medical purposes.

Objective
We aimed to identify the indications for medical cannabis reported by cannabis clinics in Ontario, Canada, and the evidence these clinics cited to support cannabis prescription.

Methods
We conducted a cross-sectional web search to identify all cannabis clinic websites within Ontario, Canada, that had physician involvement and identified their primary purpose as cannabis prescription. Two reviewers independently searched these websites to identify all medical indications for which cannabis was promoted and reviewed and critically appraised all studies cited using the Oxford Centre for Evidence-Based Medicine Levels of Evidence rubric.

Results
A total of 29 clinics were identified, promoting cannabis for 20 different medical indications including migraines, insomnia, and fibromyalgia. There were 235 unique studies cited on these websites to support the effectiveness of cannabis for these indications. A high proportion (36/235, 15.3%) of the studies were identified to be at the lowest level of evidence (level 5). Only 4 clinic websites included any mention of harms associated with cannabis.

Conclusions
Cannabis clinic websites generally promote cannabis use as medically effective but cite low-quality evidence to support these claims and rarely discuss harms. The recommendation of cannabis as a general therapeutic for many indications unsupported by high-quality evidence is potentially misleading for medical practitioners and patients. This disparity should be carefully evaluated in context of the specific medical indication and an individualized patient risk assessment. Our work illustrates the need to increase the quality of research performed on the medical effects of cannabis.
NUEVO REGISTRO DE Physalaemus riograndensis MILSTEAD, 1960 EN PARAGUAY Y COMENTARIOS SOBRE SU DISTRIBUCIÓN POTENCIAL EN EL PAÍS
Authors: Bueno-Villafañe Diego , Emhart Vuletich Jimmy , Baez Cristhian , Feltes-González Oscar 
Published: June 2023

Physalaemus riograndensis es una especie cuya distribución se extiende desde Uruguay al Noreste de Argentina, Sureste de Brasil y en dos localidades en Paraguay, en los Departamentos de Presidente Hayes e Itapúa. En Paraguay, la especie está categorizada como datos insuficientes debido a los pocos registros y ninguna información sobre su ecología. En esta nota registramos una nueva localidad donde encontramos a la especie en un ensamble activo en una sabana inundable luego de fuertes lluvias. Además, modelamos la distribución de la especie utilizando métodos de uso extensivo para determinar áreas de alta probabilidad de presencia en el país. El nuevo registro es el primero para el Departamento de Caazapá y dista 130 km al norte y a 182 km al sureste de los registros más próximos, respectivamente. Los modelos estiman que la especie es altamente probable de ocurrir al sudoeste de la región Oriental.
Development of professional identity among university students
Authors: Перченко Е.Л. , Апуневич О.А. 
Published: June 2023

В статье рассматриваются вопросы разработки и апробации учебного курса «Тренинг профессиональной идентичности» в рамках реализации траектории «Профессионализм и карьера». Обоснована методология цикла тренинговых занятий как педагогической технологии. Тренинговые занятия направленны на развитие структурных компонентов профессиональной идентичности студентов-психологов первого курса. Проведен констатирующий эксперимент для проверки гипотезы о динамических изменениях структурных компонентов профессиональной идентичности. Реализован формирующий эксперимент и представлена оценка эффективности проведенной работы по формированию профессиональной идентичности. Сформулированы психолого-педагогические условия, способствующие развитию профессиональной идентичности.
The article deals with the development and testing of the training course "Professional identity training" within the implementation of the trajectory "Professionalism and career". The authors substantiate the methodology of training sessions aimed at developing the structural components of the first-year psychology students’ professional identity as a pedagogical technology. An ascertaining experiment was conducted to test the hypothesis of dynamic changes in the structural components of professional identity in psychology students. A formative experiment is implemented and an assessment of the work effectiveness carried out to form the psychology students’ professional identity is presented. The authors define the psychological and pedagogical conditions contributing to the psychology students’ professional identity development.
Structural syntactic features of agglutinative languages (based on the Telugu and Turkish languages)
Authors: Аврутина А.С. , Попова Е.Ю. 
Published: June 2023

В статье ставится задача проанализировать с точки зрения типологического подхода особенности синтаксической подсистемы телугу и турецкого языков, а именно: порядок слов, в котором уточнение предшествует уточняемому, отсутствие согласования между компонентами атрибутивных конструкций, наличие субстантивных определительных сочетаний существительных (изафетов), синтаксические конструкции, вводимые глагольно- именными формами, малое количество союзов. В результате сравнительного анализа установлено, что данные языки демонстрируют типологическое сходство по приведённым особенностям синтаксиса.
The article describes features of Telugu and Turkish syntax from the point of view of the typological approach in linguistics: word order in which the qualifier precedes the qualified, lack of agreement between the components in attributive constructions, substantive determinative noun combinations (izafes), syntactic constructions introduced by infinite forms, few conjunctions. As a result of the comparative analysis, these languages demonstrate typological similarities in the syntactic features given.
Про комбінаторні властивості частково впорядкованих множин надсуперкритичного
MM-типу найменшого порядку
Authors: Бондаренко В. М. , Стойка М. В. , Стьопочкіна М. В. 
Published: June 2023

М. М. Клейнер довiв, що частково впорядкована (скорочено ч. в.) множина S має
скiнченний зображувальний тип тодi i лише тодi, коли вона не мiстить ч. в. пiдмножин
вигляду (1, 1, 1, 1), (2, 2, 2), (1, 3, 3), (1, 2, 5), (N, 4), а Л. А. Назарова довела,
що ч. в. множина S є ручною тодi i лише тодi, коли вона не мiстить ч. в. пiдмножин
вигляду (1, 1, 1, 1, 1), (1, 1, 1, 2), (2, 2, 3), (1, 3, 4), (1, 2, 6), (N, 5). Цi ч. в.
множини називаються вiдповiдно критичними i суперкритичними.
Ч. в. множини, якi вiдрiзняються вiд суперкритичних в тiй самiй мiрi, що суперкритичнi
вiдрiзняються вiд критичних, називаються надсуперкритичними. У цiй статтi ми вивчаємо
деякi комбiнаторнi властивостi ч. в. множин, якi мiнiмаксно iзоморфнi надсуперкритичним.
ч. в. множинам найменшого порядку.
WEAK AND STRONG ADJECTIVES IN OLD NORSE: AN EXAMINATION OF „KONUNGS SKUGGSJÁ”
Authors: WAGENER Terje 
Published: June 2023

Weak and Strong Adjectives in Old Norse: An Examination of Konungs skuggsjá. All early Germanic languages distinguish between a weak and a strong adjectival declension. This contrast is traditionally described in terms of definiteness, the strong declension expressing indefinite reference and the weak one definite reference. Such a description, however, might be more suitable with regard to Modern Scandinavian languages than to Old Norse (and other early Germanic languages), where the strong declension is found in a number of contexts where in Modern Norwegian only the weak one is acceptable, for instance with certain demonstratives and in noun phrases with possessives. This article takes a look at the Old Norse didactic work Konungs skuggsjá and examines various contexts that unambiguously require the weak declension in Modern Norwegian: demonstratives, possessives, proper nouns, vocatives and others. The role and referential properties of the determiners sá and hinn are given special focus.
REZUMAT. Adjective slabe și tari în limba norvegiană veche: o analiză a textului Konungs skuggsjá. Toate limbile germanice timpurii se diferențiază prin două tipuri de declinare adjectivală: a adjectivelor slabe și a celor tari. Acest contrast este descris în mod tradițional pornind de la tipul articolului folosit, declinarea tare făcând trimitere la referința nearticulată și cea slabă, la referința articulată. O astfel de descriere, totuși, ar putea fi mai potrivită pentru limbile scandinave moderne decât pentru limba norvegiană veche (și alte limbi germanice timpurii), în care declinarea tare se găsește într-o serie de contexte. În contrast, în limba norvegiană modernă, se acceptă doar cea slabă, de exemplu cu anumite demonstrative și în sintagmele nominale cu posesive. Acest articol prezintă textul didactic Konungs skuggsjá din limba norvegiană veche și analizează o serie de contexte care necesită în mod cert declinarea slabă în limba norvegiană modernă: demonstrative, posesive, substantive proprii, vocative și altele. Rolului și proprietăților referențiale ale determinanților sá și hin li se acordă o atenție deosebită.
Cuvinte-cheie: adjective, limba norvegiană veche, Konungs skuggsjá, determinanți sá, hinn
Article history: Received 2 February 2023; Revised 28 April 2023; Accepted 30 May 2023; Available online 23 June 2023; Available print 30 June 2023.
Agreement of cardiac output measurements by esophageal Doppler and transesophageal echocardiography with intermittent pulmonary artery thermodilution during pharmacologic manipulation of hemodynamics in anesthetized dogs
Authors: Paranjape Vaidehi V. , Pereira Fernando. L. Garcia , Menciotti Giulio , Saksena Siddharth , Guerrero Natalia Henao , Pereira Carolina H. Ricco 
Published: June 2023

Abstract

OBJECTIVE
To compare cardiac output (CO) measurements by transesophageal echocardiography (TEECO) and esophageal Doppler monitor (EDMCO) with pulmonary artery thermodilution (PATDCO) in anesthetized dogs subjected to pharmacological interventions. The effect of treatments on EDM-derived indexes was also investigated.

ANIMALS
6 healthy male dogs (10.8 ± 0.7 kg).

METHODS
Dogs were anesthetized with propofol and isoflurane, mechanically ventilated, and monitored with invasive mean arterial pressure (MAP), end-tidal isoflurane concentration (ETISO), PATDCO, TEECO, EDMCO, and EDM-derived indexes. Four treatments were administered to all dogs by randomization. Baseline data were collected before each treatment: (1) dobutamine infusion; (2) esmolol infusion; (3) phenylephrine infusion; and (4) ETISO > 3%. Data were collected after 10-minute stabilization and after 30 minutes of washout between treatments. Statistical tests were pairwise t test, Bland-Altman analysis, Lin's concordance correlation (ρc), and polar plot analysis with P < .05 set as significance.

RESULTS
The mean ± SD relative bias (limits of agreement) for TEECO was 0.35 ± 25.2% (−49.1% to 49.8%) and for EDMCO was −27.2 ± 22.5% (−71.4% to 17%) versus PATDCO. The percent error for TEECO and EDMCO was 27.6% and 44.1%, respectively. The ρc value was 0.82 for TEECO and 0.66 for EDMCO. TEECO and EDMCO showed good trending ability. EDM-derived indexes displayed significant changes specific to the drug administered (P < .001).

CLINICAL RELEVANCE
For minimally invasive CO monitoring, TEE may provide more favorable performance than EDM in clinical settings; however, EDM-derived indexes yield valuable hemodynamic information that reliably follows trends in CO, thus supporting critical decision-making in canine patients.
Realizing Renewable Energy Storage Potential in Municipalities: Identifying the Factors that Matter
Authors: Dolge Kristiāna , Toma Annija Sintija , Grāvelsiņš Armands , Blumberga Dagnija 
Published: June 2023

Abstract
The share of renewable energy in heat and power generation is expected to increase significantly and reach record levels in the coming decades. As a result, emerging energy storage technologies will be key elements in balancing the energy system. To compensate the variability and non-controllability of seasonally generated renewable energy (RES) (daily fluctuations in solar radiation intensity, wind speed, etc.) development of sufficient energy storage infrastructure in the regions will play a major role in transforming RES supply potential into reality. However, local public authorities that are responsible for creating an enabling policy environment for RES infrastructure development in regions encounter numerous challenges and uncertainties in deploying sufficient energy accumulation that often remain unanswered due to a lack of knowledge and on-site capacity, which in turn significantly hinders the regional path to climate neutrality. In this study, the PESLTE analytical framework and composite index methodology is applied to examine the multidimensional factors that influence the deployment of renewable energy storage technologies in municipalities: political, economic, social, legal, technological, and environmental. Developed model is approbated in a case study in a Latvian municipality where four different alternative energy storage technologies are compared: batteries for electricity storage, thermal energy storage, energy storage in a form of hydrogen, and energy storage in a form of biomethane.
Analysis of Fetal Chromosome Abnormalities by Karyotpye
Authors: Thi Giang An Nguyen , Thi Giang Nguyen 
Published: June 2023

Prenatal screening is a crucial method employed during the fetal stage to detect and intervene early, thereby ensuring the health of newborn babies. This approach serves to enhance the overall quality of the population and mitigate the severe consequences associated with birth defects. Prenatal screening encompasses various techniques, including epidemiological investigations, fetal imaging ultrasound, maternal blood screening, and amniotic fluid screening by karotype technique. The process involves extracting fetal chromosomes from cells present in the amniotic fluid, followed by cell culture and hypotonic treatment. Subsequently, these chromosomes are stained with G-band and examined under a microscope. The results obtained from prenatal screening in a sample of 121 patients, with an average age of 32 ± 6.69, indicated that 21% of pregnant women had experienced a miscarriage, 23.1% had previously given birth to a malformed baby, 8.3% of families had a genetic disease, and 5% of parents exhibited chromosomal abnormalities. Among the 51 patients screened using the Double test, 26.45% of fetuses exhibited a high risk of birth defects, whereas the Tripple test identified a high risk in 9.09% of the 19 cases. Chromosome analysis of the 121 cases revealed that 15.7% of the fetuses exhibited chromosomal abnormalities, with Edwards syndrome accounting for 5.78%, Down syndrome accounting for 4.96%, chromosomal abnormalities accounting for 3.30%, Patau syndrome accounting for 0.83%, and Turner syndrome accounting for 0.83%. Age over 35 years (r = 0.08 and OR = 0.63), history of miscarriage (r = 0.05 and OR = 1.38), family history of hereditary disease (r = 0.04 and OR = 1.38), and parental chromosomal mutations (r = 0.01 and OR = 1.08) were all found to have a strong positive correlation with fetal abnormalities. Additionally, positive correlations were observed between the results of ultrasound screening (r = 0.22 and OR = 5.48) and blood screening (r = 0.14 and OR = 1.22).
Prenatal screening, Amniocentesis, Karyotype, Chromosome, fetal chromosome.
Competencias digitales docente asociadas a la creación de contenidos curriculares en tiempo de Covid–19
Authors: Holguín Santana Genny Mercedes , Párraga Muñoz Sonia Monserrate 
Published: June 2023

La creación de contenidos curriculares se debe considerar como una opción base en los planes de estudios planteados por los docentes. El estudio tuvo como objetivo analizar la gestión pedagógica de aula a partir de la competencia digital docente incorporada en la creación de contenidos curriculares en las Unidades Educativas del Circuito 13D02C18 Manta-Montecristi-Jaramijó, provincia Manabí. La investigación fue de tipo cualitativo con análisis conceptual bibliográfico y cuantitativo con estudio estadístico de la información obtenida. La técnica usada fue encuestas y entrevistas. La investigación reveló un nivel aceptable de conocimiento de las herramientas informáticas para crear contenidos curriculares, pero existen falencias en su aplicabilidad en los diferentes entornos del proceso aprendizaje.
From Lotus to Plum: A Critical Comparison Between Two English-language Translators of Jin Ping Mei
Authors:   , Xiao Shuangjin 
Published: June 2023

<p>Generally recognized as one of the four masterworks of Ming fiction, Jin Ping Mei 金瓶梅 (1617) is one of the earliest premodern Chinese vernacular texts introduced to Anglophone audiences through translation. Several different English translations are currently in circulation but have received inadequate academic attention. This thesis contributes to scholarship on the English translations of Jin Ping Mei by investigating and comparing its two full-length English renderings, Clement Egerton’s The Golden Lotus (1939) and David Tod Roy’s The Plum in the Golden Vase (1993-2013), both of which are relatively underexplored in the sphere of translation studies. Its primary purpose is to demonstrate that the two translations differ significantly in representing several of the most characteristic aspects of the novel. The underlying hypothesis is that both translations are shaped in fundamental ways by their responses to their respective sociocultural milieux. To test this, the study establishes four textual corpora for critical analysis, variously covering linguistic, cultural, literary, and societal dimensions of the source text. Through analysis of textual samples, it aims to describe the two translators’ choices and strategies to deduce factors that may have influenced them. It also explores the effect of their different approaches on the target readers’ perceptions of the novel. The arguments are supported by previously unstudied material from the translators’ archives. The theoretical framework is based on descriptive translation studies, which highlights both text and context, but it also incorporates insights from linguistics, literary studies, and cultural studies. The analytical method is both quantitative and qualitative. Ultimately the study offers a deeper understanding of the complex issues faced by native English translators of premodern Chinese texts. </p>
Current approaches to quality assessment, non-clinical and clinical studies of dendritic cell vaccines in oncology
Authors: Nekhaeva T. L. , Kamaletdinova A. A. , Lutfullin M. F. , Tabanskaya T. V. 
Published: June 2023

At present, personalised cellular immunotherapy is considered a promising approach to the treatment of malignant neoplasms. The effectiveness of these cellular immunotherapy methods is evaluated in the context of clinical and biological tumour characteristics and the state of the immune system of a particular patient. One of the immunotherapy options for cancer is the development of autologous dendritic cell vaccines.The aim of this study was to analyse current methodological approaches to the evaluation of the quality, efficacy, and safety of dendritic cell cancer vaccines.This review describes the functional role of dendritic cells in immune response regulation. The paper presents the results of literature analysis covering current approaches to obtaining dendritic cell vaccines with specific characteristics, quality assessment, studies of the anti-tumour efficacy of cell therapy products, and the experience of conducting non-clinical and clinical studies. The review highlights specific aspects of international experience in the registration and clinical use of cell therapy products. The authors discuss methodological approaches to non-clinical studies of dendritic cell vaccines, which should aim to obtain information to select the dose, route, and mode of administration and to identify immunological markers correlating to the clinical efficacy of cell therapy products. The paper covers international experience in conducting clinical trials of dendritic cell vaccines for various malignant neoplasms. The authors propose a list of quality attributes of human somatic cell-based medicinal products for further clinical use.
The results of dysbiosis in the structure of periodontopathogens of the II order in patients with non-alcoholic fatty liver disease
Authors: Emelyanov D. V. , Emelyanova N. Y. 
Published: June 2023

Objective — to identificate of the quantitative composition of some representatives of II order periodontopathogens in patients with NAFLD.
Materials and methods. 108 people were selected, including 44 patients with non‑alcoholic fatty liver disease (main group), 44 people — their spouses (comparison group). The control group consisted of 20 somatically healthy volunteers. A standard dental examination was performed using hygiene and periodontal indices, and some physical parameters of saliva (salivary salinity and viscosity, oral fluid endotoxin level in volume per unit time by enzyme‑linked immunosorbent assay) were determined. Quantitative composition of Fusobacterium nucleatum, Treponema denticola, Prevotela intermedia and Porphyromonas endodontalis in periodontal pockets was performed by real‑time PCR using paper endodontic absorbents. Statistical processing was performed using SPSS statistical programs using the nonparametric method.
Results. In NAFLD, negative changes in the physical parameters of saliva were observed (decreased salivary flow rate, increased viscosity, pH shift to the acidic side), increased levels of oral endotoxin and increased quantitative content of periodontal pathogens of the second order (increase in Porphyromonas endodontalis compared to the control group by more than 4.5 times and increase in Prevotela intermedia by 2.5 times). A positive correlation was found between the presence of halitosis and the quantitative content of Fusobacterium nucleatum (r=0.40; p=0.065) and the quantitative content of Porphyromonas endodontalis (r=0.36; p=0.022). We also found a negative correlation between the level of Fusobacterium nucleatum and salivary flow rate (r=– 0.51; p=0.000) and a positive correlation with saliva viscosity (r=0.49; p=0.001).
Conclusions. The combination of exogenous and endogenous risk factors forms a dysbiotic shift of conditionally pathogenic microflora (periodontal pathogens of the second order) in the oral cavity biotope, which creates conditions for the invasion of more aggressive microorganisms and the maintenance of chronic systemic inflammation. This fact requires increased attention from both the dentist and the internist, and the patient.