bluuebunny/crossref_metadata_2025_split huggingface dataset:
BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues
Authors: Podlesny-Drabiniok Anna , Novikova Gloriia , Liu Yiyuan , Dunst Josefine , Temizer Rose , Giannarelli Chiara , Marro Samuele , Kreslavsky Taras , Marcora Edoardo , Goate Alison Mary 
Published: February 2023

AbstractBackgroundGenetic and experimental evidence strongly implicates myeloid cells in the etiology of AD and suggests that AD-associated alleles and genes may modulate disease risk by altering the transcriptional and cellular responses of macrophages (like microglia) to damage of lipid-rich tissues (like the brain). Specifically, recent single-cell/nucleus RNA sequencing (sc/nRNA-seq) studies identified a transcriptionally distinct state of subsets of macrophages in aging or degenerating brains (usually referred to as disease- associated microglia or DAM) and in other diseased lipid-rich tissues (e.g., obese adipose tissue, fatty liver, and atherosclerotic plaques). We collectively refer to these subpopulations as lipid-associated macrophages or LAMs. Importantly, this particular activation state is characterized by increased expression of genes involved in the phagocytic clearance of lipid-rich cellular debris (efferocytosis), including several AD risk genes.MethodsWe used sc/nRNA-seq data from human and mouse microglia from healthy and diseased brains and macrophages from other lipid-rich tissues to reconstruct gene regulatory networks and identify transcriptional regulators whose regulons are enriched for LAM response genes (LAM TFs) across species. We then used gene knock- down/knock-out strategies to validate some of these LAM TFs in human THP-1 macrophages and iPSC-derived microgliain vitro, as well as mouse microgliain vivo.ResultsWe nominate 11 strong candidate LAM TFs shared across human and mouse networks (BHLHE41,HIF1A,ID2,JUNB,MAF,MAFB,MEF2A,MEF2C,NACA, POU2F2andSPI1). We also demonstrate a strong enrichment of AD risk alleles in the cistrome ofBHLHE41(and its close homologBHLHE40), thus implicating its regulon in the modulation of disease susceptibility. Loss or reduction ofBHLHE40/41expression in human THP-1 macrophages and iPSC-derived microglia, as well as loss ofBhlhe40/41in mouse microglia led to increased expression of LAM response genes, specifically those involved in cholesterol clearance and lysosomal processing, with a concomitant increase in cholesterol efflux and storage, as well as lysosomal mass and degradative capacity.ConclusionsTaken together, this study nominates transcriptional regulators of the LAM response, experimentally validates BHLHE40/41 in human and mouse macrophages/microglia, and provides novel targets for therapeutic modulation of macrophage/microglia function in AD and other disorders of lipid-rich tissues.Graphical abstract
Microcircuit failure inSTXBP1encephalopathy leads to hyperexcitability
Authors: dos Santos Altair Brito , Larsen Silas Dalum , Guo Liangchen , Montalant Alexia , Verhage Matthijs , Sørensen Jakob Balslev , Perrier Jean-François 
Published: February 2023

SummaryDe novomutations inStxbp1are among the most prevalent causes of neurodevelopmental disorders, and lead to haploinsufficiency, cortical hyperexcitability, epilepsy and other symptoms. Given that Munc18-1, the protein encoded byStxbp1, is essential for both excitatory and inhibitory synaptic transmission, it is currently not understood why mutations cause hyperexcitability. We discovered that overall inhibition in canonical feedforward microcircuits is defective in a validated mouse model forStxbp1haploinsufficiency. However, unexpectedly, we found that inhibitory synapses were largely unaffected. Instead, excitatory synapses failed to recruit inhibitory interneurons. Modelling experiments confirmed that defects in the recruitment of inhibitory neurons in microcircuits cause hyperexcitation. Ampakines, compounds that enhance excitatory synapses, restored interneuron recruitment and prevented hyperexcitability. These findings identify deficits in excitatory synapses in microcircuits as a key underlying mechanism for cortical hyperexcitability inStxbp1disorder and identify compounds enhancing excitation as a direction for therapy design.Highlights- Neocortical microcircuits fail inStxbp1haploinsufficiency mouse models (Stxbp1hap)- Microcircuit impairments leads to cortical hyperexcitability due to a lack of inhibition.- Inhibitory synapses are not severely affected inStxbp1hap, instead, excitatory synapses fail to recruit interneurons.- AMPAkines rescue microcircuit failure inStxbp1hap
The influence of transformational and learning through R&D capabilities on the competitive advantage of firms
Authors: Aldabbas Hazem , Oberholzer Niël 
Published: February 2023

PurposeThis study provides theoretical and empirical insights into how firms can enhance their performance strategically and financially by integrating learning and transformational capabilities into research and development (R&D) activities based on the dynamic capabilities approach. To achieve this, the authors propose that transformational capabilities in R&D mediate the relationship between learning capabilities in R&D and competitive advantage.Design/methodology/approachUsing a purposive sampling technique and standardized questionnaires, data were collected from 118 R&D and senior managers. To analyze the data, multiple regression analysis, along with SPSS PROCESS macro (Model 4), was used.FindingsThe results support the theoretical assumption that there are direct and indirect positive and significant effects between learning capabilities in R&D and competitive advantage as mediated by transformational R&D capabilities.Originality/valueThis study explores R&D from a dynamic capabilities perspective and suggests that learning capabilities should come first to enhance businesses’ competitive advantage. Furthermore, transformational R&D capabilities can explain the relationship between learning capabilities in R&D and competitive advantage. The authors recommend that researchers should investigate the contributions of R&D to promote competitive advantage.
The impact of cruise ship dinescape on travellers’ behaviour
Authors: Björk Peter , Kauppinen-Räisänen Hannele , Sthapit Erose 
Published: February 2023

Purpose
This study aims to examine how cruise ship dinescapes, as a specific type of organized and staged service environment, influence customers’ attitudes, on-board behaviour, satisfaction and behavioural intentions.

Design/methodology/approach
Data was collected using a cross-sectional survey from 552 passengers on-board one of the big cruise ships with a Caribbean itinerary.

Findings
Cruise ship dinescape, as an on-board food experience platform, is built on three dimensions: restaurant atmospherics, interactions with other guests and restaurant staff. The findings show how these dimensions influence passengers’ emotional experiences and quality perceptions. The results also show how travellers’ cruise ship dinescape satisfaction affect their overall vacation satisfaction and future travel behaviour.

Practical implications
The findings imply that cruise companies should pay extra attention to organised food service environments like dinescapes staged for passengers. Through these scapes cruise companies may provide favourable platforms enabling dining satisfaction, but also social interaction and co-creation of memorable experiences.

Originality/value
This study builds a comprehensive model in cruise ship context, which links dinescape experiences to overall cruise ship dining experiences and dining behaviour mediated by emotional and perceived quality outcomes with further consequences.
Unethical pro-family behavior: a literature review and implications for managers
Authors: Mishra Madhurima , Dharmani Pranav 
Published: February 2023

Purpose
The purpose of this study is to synthesize the developing body of literature on unethical pro-family behavior (UPFB) and formulate a theoretical framework. It also discusses implications for managers on how to reduce the occurrence of unethical pro-family behavior in organizations.

Design/methodology/approach
This study draws on peer-reviewed research papers published in the realm of unethical pro-family behavior.

Findings
The theoretical framework presented in this study lists the factors that are known to motivate employees to engage in unethical pro-family behavior. The framework also details the deterrents of unethical pro-family behavior.

Originality/value
This study is probably the first to integrate the emerging body of research on UPFB. The framework developed in this study is also relevant for practicing managers as it enlightens them about the enablers and inhibitors of unethical pro-family behavior in the workplace.
Risk management research in East Asia: a bibliometric analysis
Authors: Zhang Lili , Ling Jie , Lin Mingwei 
Published: February 2023

PurposeThe aim of this paper is to present a comprehensive analysis of risk management in East Asia from 1998 to 2021 by using bibliometric methods and tools to explore research trends, hotspots, and directions for future research.Design/methodology/approachThe data source for this paper is the Web of Science Core Collection, and 7,154 publications and related information have been derived. We use recognized bibliometric indicators to evaluate publications and visually analyze them through scientific mapping tools (VOS Viewer and CiteSpace).FindingsThe analysis results show that China is the most productive and influential country/region. East Asia countries have strong cooperation with each other and also have cooperation with other countries. The study shows that risk management has been involved in various fields such as credit, supply chain, health emergency and disaster especially in the background of COVID-19. We also found that machine learning, especially deep learning, has been playing an increasingly important role in risk management due to its excellent performance.Originality/valueThis paper focuses on studying risk management in East Asia, exploring its publication's fundamental information, citation and cooperation networks, hotspots, and research trends. It provides some reference value for scholars who are interested or further research in this field.
The interplay between framing effects, cognitive biases, and learning styles in online purchasing decision: lessons for Iranian enterprising communities
Authors: Emami Amir , Taheri Zeinab , Zuferi Rasim 
Published: February 2023

Purpose
This paper aims to investigate the interactive relationship between learning styles and cognitive biases as two essential factors affecting information processing in online purchases.

Design/methodology/approach
This research is applied in nature but extends the knowledge in the area of consumer behavior. By using the correlational research method, the present study uncovers the relationship between various sorts of decision biases and learning styles among online buyers.

Findings
According to the results, the most affected learning style among all is reflective observation. Several biases influence people with this learning style, namely, risky framing, attribute framing and aggregated/segregated framing. In the case of active experimentation, online customers can undo its effect. Therefore, online sellers should be aware of their target customers with such a learning style. In addition, online purchasers with the reflective observation learning style are more prone to aggregation and segregation of sales information.

Originality/value
The findings enhance the understanding of consumer buying behavior and the extent to which learning styles impact cognitive biases and framing effects in online shopping.
Positioning in SMEs: entrepreneurs’ perceptions and strategies
Authors: Fluhrer Peter , Brahm Taiga 
Published: February 2023

Purpose
The concept of positioning is fundamental to how a company approaches and succeeds in a market. Despite a growing body of literature on positioning, existing research has focused mainly on larger companies and brands. This paper aims to apply the concept of positioning to small- and medium-sized enterprises (SME) companies to explore how SME entrepreneurs understand and approach the positioning of their company, and what differences exist compared to large companies and brands.

Design/methodology/approach
Using a qualitative research approach, this study is based on focus groups involving 13 SME entrepreneurs. The data were analyzed using a qualitative structuring content analysis, which resulted in a newly developed and empirically based typology of SME positioning strategies.

Findings
The results indicate that SME entrepreneurs view positioning as highly relevant but differ from larger companies in terms of market and brand orientation. Building on the interviews, an empirical matrix of four positioning strategies was developed which SME entrepreneurs typically use: specialization, differentiation, conviction and opposition.

Practical implications
Based on the developed positioning typology, this study proposes a two-step approach for SME entrepreneurs: gaining clarity on the basic positioning dimensions and exploring four strategic fields of action.

Originality/value
Overall, the findings contribute to a better understanding of SME entrepreneurs' positioning strategies as important building blocks for market and brand success. The new positioning typology provides a conceptual contribution for further research in the marketing/entrepreneurship interface.
Humanising care in a forensic mental health ward through creative writing workshops for staff and residents: a case study
Authors: Chatterjee Paula , Turri Maria Grazia 
Published: February 2023

Purpose
Service users’ voice is at the forefront of movements within psychiatry that look to create more humanising care. Although genuine co-production of knowledge is limited by the power differential intrinsically functional to the health care setting, the arts have the potential to create collaborative environments and equalise relationships. The purpose of this case study is to describe and discuss the design and pilot evaluation of creative writing workshops in a forensic mental health ward as an innovative method for humanising care.

Design/methodology/approach
A creative writing intervention focussing on everyday experiences was implemented in a forensic mental health ward and involved four residents and four mental health professionals working together. Interviews were conducted with the four mental health professionals as part of a service evaluation. Transcripts were analysed using thematic analysis.

Findings
Two themes emerged from the analysis of interviews with mental health professionals: “a new way of learning about each other” and “imagining beyond the staff-resident relationship”. The authors discuss the intervention’s benefits in terms of its potential to foster mutuality and empathy beyond the illness narrative.

Practical implications
Creative writing can be used to engage patients and mental health professionals to jointly share everyday experiences and identities beyond illness.

Originality/value
The creative writing workshops present an innovative approach concerning the use of creative arts for humanising care through mutuality.
Explaining consumer–brand forgiveness through the lens of narcissism
Authors: Siamagka Nikoletta-Theofania 
Published: February 2023

PurposeThe purpose of this paper is to investigate the impact of two types of narcissism (rivalry and admiration) on consumer–brand forgiveness (CBF) following a brand transgression. This research also examines how narcissism interacts with transgression type to shape forgiveness intentions.Design/methodology/approachData were collected through an online survey of 634 UK consumers, focussing on two different types of transgressions (public vs private). The formulated hypotheses were tested through moderated mediation analysis.FindingsThe results highlight that only narcissistic rivalry (and not admiration) moderates the relationship between transgression type and blame attributions. Although the type of transgression seems to affect CBF, forgiveness levels do not vary across the two transgression types. Finally, as expected, blame attributions shape forgiveness intentions.Practical implicationsThe results of this research highlight that blame attributions are affected by the type of narcissism. Thus, identifying the type of narcissism will allow brands to allocate their resources more effectively in order to design recovery strategies that would promote CBF and restore brand trust.Originality/valueThe paper responds to calls for a better understanding of forgiveness through the use of personality traits and focusses on two dimensions of narcissism. This paper also uses a novel transgression typology, which is objective in nature. The results illustrate that narcissism has a differential role in shaping blame attributions and CBF.
Horizontal and vertical responsibilisation in the resettlement field
Authors: Cracknell Matthew 
Published: February 2023

Purpose
The Offender Rehabilitation Act 2014 extended post-release supervision to individuals serving short prison sentences while introducing an extended array of actors into the resettlement field. This paper aims to explore the barriers that prison practitioners and community probation workers faced in their attempts to provide resettlement support, and how in response to these barriers, these practitioners enacted particular responsibilisation strategies.

Design/methodology/approach
This empirical research features the perspectives of 19 prison, probation and third-sector actors within a case-study area in England. Qualitative interviews were carried out, alongside observations and field notes of daily practice.

Findings
Findings indicate that despite the promise of additional support, practitioners face significant barriers inhibiting their ability to provide effective resettlement assistance. The three specific barriers identified are institutional, temporal and political-economic. In response, practitioners enacted particular responsibilisation strategies, shifting blame vertically down to service users and horizontally towards the other actors involved in managing these individuals.

Practical implications
This article concludes with a brief overview of the latest iteration of resettlement practice, before exploring how a desistance-focused approach by practitioners may improve resettlement outcomes.

Originality/value
These findings help to expand our understanding of the responsibilisation literature, particularly how responsibilisation operates at a practitioner level, and how barriers become refracted and reframed into responsibilisation strategies. This article also draws on the “mass supervision” literature to demonstrate how the introduction of multiple agencies obfuscates individual responsibility for resettlement and large caseloads erode supervisory practice.
Chemical composition, chemotypic characterization, and histochemical localization of volatile components in different cultivars of Zanthoxylum bungeanum Maxim. leaves
Authors: Xu Shengnan , Yu Li , Hou Yuping , Huang Bo , Wang Hong , Li Dengwu , Wang Dongmei 
Published: February 2023

AbstractZanthoxylum bungeanum Maxim., an important spice plant, is rich in volatile components and has formed several cultivars in China. Genetic variation among different cultivars has significant effects on volatile components. In this study, a total of 52 volatile compounds were detected from 11 cultivars of Z. bungeanum, among which palmitic acid, (+)‐limonene, phytol, β‐caryophyllene, and terpinyl acetate were screened as characteristic compounds, with palmitic acid and phytol contributing the most to the volatile composition. Combined with the results of chemometric and content analyses, three Z. bungeanum chemotypes were identified: (+)‐limonene, β‐caryophyllene + terpinyl acetate, and palmitic acid + phytol. In addition, the dynamics of the accumulation of its main components were explored, and the optimal harvest period for Z. bungeanum leaves (late July or early August) was clarified. Moreover, histochemical analysis results showed that terpenoids were mainly accumulated in the oil cells of Z. bungeanum leaves, and there were some differences in the number of oil cells in different chemotypes of Z. bungeanum, which might affect the yield and quality of volatile components. The results showed that the differences of chemical composition among diverse chemotypes of Z. bungeanum might be an important factor leading to the quality differences of the same planting resources. Accordingly, the study on the classification of Z. bungeanum chemotypes and the accumulation patterns of major chemical components is of great theoretical significance and practical value as a favorable guarantee for the development and utilization of Z. bungeanum resources and quality control.
Scientific novelty beyond the experiment
Authors: Hallsworth John E. , Udaondo Zulema , Pedrós‐Alió Carlos , Höfer Juan , Benison Kathleen C. , Lloyd Karen G. , Cordero Radamés J. B. , de Campos Claudia B. L. , Yakimov Michail M. , Amils Ricardo 
Published: February 2023

AbstractPractical experiments drive important scientific discoveries in biology, but theory‐based research studies also contribute novel—sometimes paradigm‐changing—findings. Here, we appraise the roles of theory‐based approaches focusing on the experiment‐dominated wet‐biology research areas of microbial growth and survival, cell physiology, host–pathogen interactions, and competitive or symbiotic interactions. Additional examples relate to analyses of genome‐sequence data, climate change and planetary health, habitability, and astrobiology. We assess the importance of thought at each step of the research process; the roles of natural philosophy, and inconsistencies in logic and language, as drivers of scientific progress; the value of thought experiments; the use and limitations of artificial intelligence technologies, including their potential for interdisciplinary and transdisciplinary research; and other instances when theory is the most‐direct and most‐scientifically robust route to scientific novelty including the development of techniques for practical experimentation or fieldwork. We highlight the intrinsic need for human engagement in scientific innovation, an issue pertinent to the ongoing controversy over papers authored using/authored by artificial intelligence (such as the large language model/chatbot ChatGPT). Other issues discussed are the way in which aspects of language can bias thinking towards the spatial rather than the temporal (and how this biased thinking can lead to skewed scientific terminology); receptivity to research that is non‐mainstream; and the importance of theory‐based science in education and epistemology. Whereas we briefly highlight classic works (those by Oakes Ames, Francis H.C. Crick and James D. Watson, Charles R. Darwin, Albert Einstein, James E. Lovelock, Lynn Margulis, Gilbert Ryle, Erwin R.J.A. Schrödinger, Alan M. Turing, and others), the focus is on microbiology studies that are more‐recent, discussing these in the context of the scientific process and the types of scientific novelty that they represent. These include several studies carried out during the 2020 to 2022 lockdowns of the COVID‐19 pandemic when access to research laboratories was disallowed (or limited). We interviewed the authors of some of the featured microbiology‐related papers and—although we ourselves are involved in laboratory experiments and practical fieldwork—also drew from our own research experiences showing that such studies can not only produce new scientific findings but can also transcend barriers between disciplines, act counter to scientific reductionism, integrate biological data across different timescales and levels of complexity, and circumvent constraints imposed by practical techniques. In relation to urgent research needs, we believe that climate change and other global challenges may require approaches beyond the experiment.