bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vulnerability of the ventricular conduction axis during transcatheter aortic valvar implantation: A translational pathologic study
Authors: Tretter Justin T. , Spicer Diane E. , Macías Yolanda , Talbott Cheryl , Kasten Jennifer L. , Sánchez‐Quintana Damián , Kapadia Samir R. , Anderson Robert H. 
Published: March 2023

AbstractThe ventricular components of the conduction axis remain vulnerable following transcatheter aortic valvar replacement. We aimed to describe features which may be used accurately by interventionalists to predict the precise location of the conduction axis, hoping better to avoid conduction disturbances. We scanned eight normal adult heart specimens by 3T magnetic resonance, using the images to simulate histological sections in order accurately to place the conduction axis back within the heart. We then used histology, tested in two pediatric hearts, to prepare sections, validated by the magnetic resonance images, to reveal the key relationships between the conduction axis and the aortic root. The axis was shown to have a close relationship to the nadir of the right coronary leaflet, in particular when the aortic root was rotated in counterclockwise fashion. The axis was more vulnerable in the setting of a narrow inferoseptal recess, when the inferior margin of the membranous septum was above the plane of the virtual basal ring, and when minimal myocardium was supporting the right coronary sinus. The features identified in our study are in keeping with the original description provided by Tawara, but at variance with more recent accounts. They suggest that the vulnerability of the axis during transcatheter valvar replacement can potentially be inferred on the basis of knowledge of the position of the aortic root within the ventricular base. If validated by clinical studies, our findings may better permit avoidance of new‐onset left bundle branch block following transcatheter aortic valvar replacement.
A rare adverse event of atorvastatin inducing leukocytoclastic vasculitis with ANCA‐negative (Anti‐Neutrophil cytoplasmic antibody) case report and literature review
Authors: Guevara‐Rodriguez Nehemias , Flores‐Chang Mailing , Chilakala Akhila , Contreras Jose , Perdomo Paula , Liliya Gandrabur 
Published: March 2023

AbstractLeukocytoclastic vasculitis is an entity associated with drugs, infections, cryoglobulinemia, and connective tissue diseases but can also be idiopathic, systemic, or organ localized. Moreover, LCV associated with drugs is a rare disorder. When it is present usually has an elevation of anti‐neutrophil cytoplasmic antibody, most likely anti‐myeloperoxidase, which can be helpful to orient the diagnosis. We are presenting a 55‐year‐old female with a past medical history of diabetes mellitus (DM) and hyperlipidemia (HLD) who presented with a painful and pruritic rash localized in the abdomen and lower extremities that started 1 week after initiated atorvastatin for management of hyperlipidemia. This is the first case ever reported of leukocytoclastic vasculitis ANCA negative associated with atorvastatin, to our best knowledge.
Bilateral peripheric facial nerve palsy following SARS‐CoV‐2 infection: A case report and review of literature
Authors: Dezfouli Majid , Moeinzadeh Firouzeh , Ghiasi Farzin , Abdeyazdan Neda , Mazaheri‐Tehrani Sadegh 
Published: March 2023

AbstractNeurologic complications of SARS‐CoV‐2 infection have been reported commonly. Peripheric facial nerve palsy is one of the most reported neurologic problems. However, idiopathic bilateral facial palsy is a very rare complication of SARS‐CoV‐2 infection. Herein, we present a case of a COVID‐19 35‐year‐old man, which developed bilateral facial palsy.
Dramatic response to radiation of a sinus melanoma: A case report
Authors: Garousi Maryam , Hariri Ramyar , Fadavi Pedram , Yousefi Tahere , Bayani Reyhaneh 
Published: March 2023

AbstractIn this report, we shared our experience in the treatment of a patient with unresectable sinonasal melanoma, in whom a complete radiographic response was seen after a course of conventional external beam radiotherapy. Given that local control has an important role in maintaining the quality of life of patients.
Catalysts for Isocyanate Cyclotrimerization
Authors: Guo Yunfei , Muuronen Mikko , Lucas Frédéric , Sijbesma Rint P. , Tomović Željko 
Published: March 2023

AbstractThe formation of isocyanurate via cyclotrimerization of isocyanates is widely reported to provide a variety of polyurethane materials with improved chemical and physical properties such as weatherability, mechanical properties, thermal stability and flame retardancy. The demand for development of effective and selective catalysts for cyclotrimerization of isocyanates has been increasing. This review comprehensively summarizes catalysts for the cyclotrimerization of isocyanates that have been reported in peer‐reviewed publications and provides a valuable guideline for choosing suitable catalysts to match specific requirements. The catalysts are categorized into two main classes: catalysts operating via a Lewis basic cyclotrimerization mechanism and metal‐containing catalysts. Catalyst structures, reaction conditions, reaction time, catalytic effectivity as well as types of isocyanates whose trimerization is catalyzed are described in detail. In addition, featuring the findings and viewpoints from mechanistic studies, this review aims to stimulate the design and development of new, more efficient catalysts, and to guide further study of the trimerization mechanism with different classes of catalysts.
On‐line Optimization of Integrated Carbon Capture and Conversion Process via the Ratings Concept: A Combined DFT and Microkinetic Modeling Approach
Authors: Noppakhun Jakapob , Rittiruam Meena , Saelee Tinnakorn , Shaikh Jasmin Shamshoddin , Khajondetchairit Patcharaporn , Praserthdam Supareak , Praserthdam Piyasan 
Published: March 2023

AbstractThe integrated carbon capture and conversion (ICCC) is a promising catalytic process to produce syngas from CO2 and CH4 via a combined separation and reactor unit. Besides, its performance can fluctuate from the inconsistent feed ratio resulting from the flue gas unit. Herein, the Ratings concept based on density functional theory (DFT) is applied to overcome these problems in a two‐step protocol: (i) catalyst identification, which designates the catalyst characteristics and predicts performance based on reactivity (RT−R) and stability (RT−S) Ratings calculated based on activation energies obtained either from experiments or DFT, and (ii) catalyst optimization that optimized a catalyst's performance via the determination of new operating condition accounted for its deactivation over time. Moreover, temperature and feed ratio sensitivity were investigated, revealing that most catalysts are more sensitive to temperature change than the feed ratio.
CryoEM Structure with ATP Synthase Enables Late‐Stage Diversification of Cruentaren A
Authors: Dou Xiaozheng , Guo Hui , D'Amico Terin , Abdallah Leah , Subramanian Chitra , Patel Bhargav A. , Cohen Mark , Rubinstein John L. , Blagg Brian S. J. 
Published: March 2023

AbstractCruentaren A is a natural product that exhibits potent antiproliferative activity against various cancer cell lines, yet its binding site within ATP synthase remained unknown, thus limiting the development of improved analogues as anticancer agents. Herein, we report the cryogenic electron microscopy (cryoEM) structure of cruentaren A bound to ATP synthase, which allowed the design of new inhibitors through semisynthetic modification. Examples of cruentaren A derivatives include a trans‐alkene isomer, which was found to exhibit similar activity to cruentaren A against three cancer cell lines as well as several other analogues that retained potent inhibitory activity. Together, these studies provide a foundation for the generation of cruentaren A derivatives as potential therapeutics for the treatment of cancer.
Cu(OAc)2‐Mediated Synthesis of Fullerodihydropyridine‐3‐ones via the Reaction of [60]Fullerene with β‐Substituted Ethylamines in the Absence or Presence of Arylacetaldehydes†
Authors: Liu Xiu‐Shan , Wang Hui‐Juan , Wu Fei‐Lun , Huo Jing‐Wen , Wang Xing‐Yu , Li Fa‐Bao , Sun Rui , Liu Li , Liu Chao‐Yang 
Published: March 2023

Comprehensive SummaryA series of unreported fullerodihydropyridine‐3‐ones were synthesized as a new family of fullerene derivatives in moderate to good yields by a simple one‐step reaction of [60]fullerene with cheap and readily available β‐substituted ethylamines in the absence or presence of arylacetaldehydes under the assistance of Cu(OAc)2. The in situ generation of arylacetaldehydes by the C—N bond cleavage of arylethylamines avoided their complex synthesis in advance and realized the preparation of fullerodihydropyridine‐3‐ones with structural and functional diversities, which may have promising applications in perovskite solar cells to improve the performance of photovoltaic devices due to the existence of a large π‐conjugated system on the dihydropyridine‐3‐one ring.
Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low‐grade ovarian carcinoma
Authors: Hendrikse Cynthia S. E. , van der Ploeg Phyllis , van de Kruis Nienke M. A. , Wilting Jody H. C. , Oosterkamp Floor , Theelen Pauline M. M. , Lok Christianne A. R. , de Hullu Joanne A. , Smedts Huberdina P. M. , Vos M. Caroline , Pijlman Brenda M. , Kooreman Loes F. S. , Bulten Johan , Lentjes‐Beer Marjolein H. F. M. , Bosch Steven L. , van de Stolpe Anja , Lambrechts Sandrina , Bekkers Ruud L. M. , Piek Jurgen M. J. 
Published: March 2023

AbstractBackgroundAdvanced low‐grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed in patients with LGOC, which suggests that antihormonal therapy (AHT) is a treatment option. However, only a subgroup of patients respond to AHT, and this response cannot be adequately predicted by currently used immunohistochemistry (IHC). A possible explanation is that IHC only takes the ligand, but not the activity, of the whole signal transduction pathway (STP) into account. Therefore, in this study, the authors assessed whether functional STP activity can be an alternative tool to predict response to AHT in LGOC.MethodsTumor tissue samples were obtained from patients with primary or recurrent LGOC who subsequently received AHT. Histoscores of ER and progesterone receptor (PR) were determined. In addition, STP activity of the ER STP and of six other STPs known to play a role in ovarian cancer was assessed and compared with the STP activity of healthy postmenopausal fallopian tube epithelium.ResultsPatients who had normal ER STP activity had a progression‐free survival (PFS) of 16.1 months. This was significantly shorter in patients who had low and very high ER STP activity, with a median PFS of 6.0 and 2.1 months, respectively (p < .001). Unlike ER histoscores, PR histoscores were strongly correlated to the ER STP activity and thus to PFS.ConclusionsAberrant low and very high functional ER STP activity and low PR histoscores in patients with LGOC indicate decreased response to AHT. ER IHC is not representative of functional ER STP activity and is not related to PFS.
Approach to Evaluation of Electrocatalytic Water Splitting Parameters, Reflecting Intrinsic Activity: Toward the Right Pathway
Authors: Nazari Mahrokh , Ghaemmaghami Mostafa 
Published: March 2023

AbstractThe development of transition metal‐based non‐precious‐metal electrocatalysts for energy storage and conversion systems has received a lot of interest recently. To further this subject in the proper way given the development of electrocatalysts, a fair comparison of their respective performance is necessary. This Review investigates the parameters used for the comparison of electrocatalyst activity. Significant evaluation criteria employed in electrochemical water splitting studies are the overpotential at defined current density usually at 10 mA per geometric surface area, Tafel slope, exchange current density, mass activity, specific activity and turnover frequency (TOF). This Review will discuss how to identify the specific activity and TOF by electrochemical and non‐electrochemical methods to represent intrinsic activity as well as the benefits and uncertainties of each technique, ensuring that each method is applied correctly when calculating intrinsic activity metrics.
LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising JAK1 mRNA in an m6A‐YTHDF2‐dependent manner
Authors: Fang Yuan , Wu Xi , Gu Yunru , Shi Run , Yu Tao , Pan Yutian , Zhang Jingxin , Jing Xinming , Ma Pei , Shu Yongqian 
Published: March 2023

AbstractBackgroundN6‐methyladenosine (m6A) RNA modification is known as a common epigenetic regulation form in eukaryotic cells. Emerging studies show that m6A in noncoding RNAs makes a difference, and the aberrant expression of m6A‐associated enzymes may cause diseases. The demethylase alkB homologue 5 (ALKBH5) plays diverse roles in different cancers, but its role during gastric cancer (GC) progression is not well known.MethodsThe quantitative real‐time polymerase chain reaction, immunohistochemistry staining and western blotting assays were used to detect ALKBH5 expression in GC tissues and human GC cell lines. The function assays in vitro and xenograft mouse model in vivo were used to investigate the effects of ALKBH5 during GC progression. RNA sequencing, MeRIP sequencing, RNA stability and luciferase reporter assays were performed to explore the potential molecular mechanisms involved in the function of ALKBH5. RNA binding protein immunoprecipitation sequencing (RIP‐seq), RIP and RNA pull‐down assays were performed to examine the influence of LINC00659 on the ALKBH5–JAK1 interaction.ResultsALKBH5 was highly expressed in GC samples and associated with aggressive clinical features and poor prognosis. ALKBH5 promoted the abilities of GC cell proliferation and metastasis in vitro and in vivo. The m6A modification on JAK1 mRNA was removed by ALKBH5, which resulted in the upregulated expression of JAK1. LINC00659 facilitated ALKBH5 binding to and upregulated JAK1 mRNA depending on an m6A‐YTHDF2 manner. Silencing of ALKBH5 or LINC00659 disrupted GC tumourigenesis via the JAK1 axis. JAK1 upregulation activated the JAK1/STAT3 pathway in GC.ConclusionALKBH5 promoted GC development via upregulated JAK1 mRNA expression mediated by LINC00659 in an m6A‐YTHDF2‐dependent manner, and targeting ALKBH5 may be a promising therapeutic method for GC patients.
Improved estimation of the ratio of detection efficiencies of excited acceptors and donors for FRET measurements
Authors: Batta Ágnes , Hajdu Tímea , Nagy Peter 
Published: March 2023

AbstractFörster resonance energy transfer (FRET) is a radiationless interaction between a donor and an acceptor whose distance dependence makes it a sensitive tool for studying the oligomerization and the structure of proteins. When FRET is determined by measuring the sensitized emission of the acceptor, a parameter characterizing the ratio of detection efficiencies of an excited acceptor versus an excited donor is invariably involved in the formalism. For FRET measurements involving fluorescent antibodies or other external labels, this parameter, designated by α, is usually determined by comparing the intensity of a known number of donors and acceptors in two independent samples leading to a large statistical variability if the sample size is small. Here, we present a method that improves precision by applying microbeads with a calibrated number of antibody binding sites and a donor‐acceptor mixture in which donors and acceptors are present in a certain, experimentally determined ratio. A formalism is developed for determining α and the superior reproducibility of the proposed method compared to the conventional approach is demonstrated. Since the novel methodology does not require sophisticated calibration samples or special instrumentation, it can be widely applied for the quantification of FRET experiments in biological research.
Influence of vegetation lodging on the flow regime and resistance characteristic of overland flow
Authors: Zhang Jingzhou , Zhang Shengtang , Wang Chuantao , Wang Wenjun , Ma Lijun , Xu Xuefeng , Zhou Jiansen 
Published: March 2023

AbstractVegetation lodging downstream under overland flow is a common phenomenon; it changes the characteristics of the overland flow regime and causes the resistance effect. At present, there are few studies on the hydraulic characteristics of the slope flow caused by vegetation lodging, and the problem of the flow resistance of the vegetation morphology has been neglected or simplified, which is likely to cause large deviations in overland flow forecast. To clarify the effect of vegetation lodging on overland flow, under the conditions of slope (0.0%–3.0%) and flow discharge (0.0005–0.008 m3/s), an indoor flume experiment of vegetation gradient lodging combination and lodging angle was carried out, and the resistance mechanism and flow regime characteristics were compared and discussed. The results show that it is reasonable to use a uniform lodging angle to simulate the influence of gradient lodging on the overland flow resistance. The slope and vegetation lodging states are important factors that affect the evolution of flow patterns and turbulence changes. It was found that, as the slope or degree of vegetation lodging increased, the flow patterns evolved from slow to rapid. Under the same flow discharge, the resistance of overland flow decreased with an increase in the vegetation lodging angle. Under unsubmerged conditions, the resistance coefficient f was found to be positively correlated with the Reynolds number Re and the cosine of the lodging angle θ, and negatively correlated with the slope S. Compared with vertical vegetation, the morphological resistance of vegetation with lodging angles of 20°, 40°, 60°, and 80° decreased by 10.28%, 32.53%, 52.45%, and 61.37%, respectively. The morphology of vegetation lodging is the main influencing factor that constitutes flow resistance and controls hydraulic erosion. This study provides a theoretical basis for the prediction of overland flow and soil erosion control.
Reactivity of Cytosine with Alkylmercury Ions in the Gas Phase: The Critical Role of the Alkyl Chain
Authors: Salpin Jean‐Yves , Haldys Violette , Guillemin Jean‐Claude , Mó Otilia , Yáñez Manuel , Montero‐Campillo M. Merced 
Published: March 2023

AbstractThe gas‐phase reactivity towards cytosine (C) of alkylmercury cations CnH2n+1Hg+, and more particularly CH3Hg+, C2H5Hg+,n‐C4H9Hg+andt‐C4H9Hg+, has been studied for the first time by combining tandem mass spectrometry, infrared multiple photon dissociation spectroscopy (IRMPD) and density functional theory (DFT) calculations. Under electrospray conditions, the interaction ofCwith the cations derived from alkylmercury chloride compounds gives rise to a single type of complex of general formula [RHg(C)]+, except fort‐butylmercury which turned to be unreactive. Subsequent MS/MS experiments showed that [RHg]+ions (R=Me, Et, n‐Bu) exhibit a peculiar reactivity characterized by the transfer of the alkyl group, R, to the nucleobase leading to a [(C)R]+ion, accompanied by the reduction of the metal and loss of0Hg. As the length of the alkyl chain increases (n≥2), a new fragmentation path leading to protonated cytosine is opened, associated with the elimination of a Cn,H2n,Hg moiety. This latter process is clearly overwhelming withn‐BuHg+. The mechanisms associated with both dissociation channels were examined through the use of IRMPD data in the fingerprint region, and by exploring the corresponding potential energy surfaces in the DFT framework.
“You do need to do the interaction”: Mothers’ perceptions of responsive parenting following a home‐based parenting intervention
Authors: Morris Sophie Stucley , Price Anna , McKenzie Vicki , Kemp Lynn 
Published: March 2023

AbstractResponsive parenting (also known as responsivity) is a dynamic and bidirectional exchange between the parent‐child dyad and associated with a child's social and cognitive development. Optimal interactions require a sensitivity and understanding of a child's cues, responsiveness to the child's need, and a modification of the parent's behavior to meet this need. This qualitative study explored the impact of a home visiting program on mothers’ perceptions of their responsivity to their children. This study is part of a larger body of research known as right@home, an Australian nurse home visiting program promoting children's learning and development. Preventative programs such as right@home prioritize population groups experiencing socioeconomic and psychosocial adversity. They provide opportunities to promote children's development through the enhancement of parenting skills and an increase in responsive parenting. Semi‐structured interviews were conducted with 12 mothers, providing insight into their perceptions of responsive parenting. Four themes were extracted from the data using inductive thematic analysis. These indicated that: (1) mothers’ perceived preparation for parenting, (2) recognition of mother and child needs, (3) response to mother and child needs, and (4) motivation to parent with responsiveness, were considered important. This research highlights the importance of interventions that focus on the parent‐child relationship in increasing mother's parenting capabilities and promoting responsive parenting.
Evaluation of the Danish version of the prenatal parental reflective functioning questionnaire in early pregnancy as a screening tool
Authors: Schwartz Mads , Rasmussen Ida Scheel , Wilson Philip , Overbeck Gritt , Siersma Volkert 
Published: March 2023

AbstractParental reflective functioning (PRF) is the capacity to focus on feelings and experiences in oneself as a parent and in the child. Research has demonstrated that, the better the PRF the better outcomes for the child. This paper evaluated the Danish version of the prenatal parental reflective functioning questionnaire (P‐PRFQ). We used data from a cluster‐randomized trial of pregnant women recruited from Danish general practice. The sample included 605 mothers. Factor structure and internal consistency were investigated. Linear regression analysis was used to examine the associations between the P‐PRFQ score and the five most predictive variables. The confirmatory factor analyses supported the three‐factor model. The P‐PRFQ had moderate internal consistency. The regression analysis showed a decrease in the P‐PRFQ score with increasing age, increasing parity, current employment, better self‐reported health, lower anxiety score, and fewer negative life events with persistent impact. The directions of the associations between P‐PRFQ score and the predictive variables were opposite of what was hypothesized raising questions about whether the P‐PRFQ can be used as an early pregnancy screening tool assessing prenatal PRF. Further validation studies are required to assess the extent to which the P‐PRFQ truly measures reflective functioning.