bluuebunny/crossref_metadata_2025_split huggingface dataset:
Models of light absorption enhancement in perovskite solar cells by plasmonic nanoparticles
Authors: Zheng Daming , Pauporté Thierry , Schwob Catherine , Coolen Laurent 
Published: September 2023

AbstractNumerous experiments have demonstrated improvements on the efficiency of perovskite solar cells by introducing plasmonic nanoparticles, however, the underlying mechanisms are still not clear: the particles may enhance light absorption and scattering, as well as charge separation and transfer, or the perovskite's crystalline quality. Eventually, it can still be debated whether unambiguous plasmonic increase of light absorption has indeed been achieved. Here, various optical models are employed to provide a physical understanding of the relevant parameters in plasmonic perovskite cells and the conditions under which light absorption may be enhanced by plasmonic mechanisms. By applying the recent generalized Mie theory to gold nanospheres in perovskite, it is shown that their plasmon resonance is conveniently located in the 650–800 nm wavelength range, where absorption enhancement is most needed. It is evaluated for which active layer thickness and nanoparticle concentration a significant enhancement can be expected. Finally, the experimental literature on plasmonic perovskite solar cells is analyzed in light of this theoretical description. It is estimated that only a tiny portion of these reports can be associated with light absorption and point out the importance of reporting the perovskite thickness and nanoparticle concentration in order to assess the presence of plasmonic effects.
Co‐creating knowledge with undocumented Filipino students:Kuwentuhanas a research method
Authors: Gutierrez Rose Ann E. , Piñon Hazel , Valmocena Marie Trisha 
Published: September 2023

AbstractWe conceptualizekuwentuhanas a methodological disruption to Western constructs of research. The purpose of this article is two‐fold: first, to conceptualize and explicitly namekwentuhanas a research method and two, to reclaim Filipino epistemology and ontology through language. We orientkuwentuhanwithin the framework ofSikolohiyang Pilipinoand more specifically, the concept ofkapwaand discuss three elements ofkwentuhanas a research method to use with and for undocumented Filipino students. Our implications offer conceptual nourishment in conducting critical and humanizing research and practice with and for undocumented students rooted in their culture.Practical TakeawaysResearchers and practitioners must get to know people as people first orkapwa‐tao(fellow human being), an ontological orientation ofkwentuhan.Researchers and practitioners need to understand undocumented students’ narratives do not exist in a vacuum. Rather, individual narratives, when talking story with another individual, are part of a larger constellation of stories or a collective story of one's own people shaped by broader sociopolitical and historical contexts.Researchers and practitioners must hold themselves accountable to continuously educating themselves about the cultures of students they are working with outside of the professional space and how contemporary sociopolitical discourses are impacting undocumented students’ daily realities.Researchers and practitioners should critically reflect about their positionality, or position in relation to power, and the dynamics and contexts in which power shifts throughout their working relationship with undocumented students from different racial and ethnic groups.
Influence of breastfeeding education and support on predominant breastfeeding: Findings from a community‐based prospective cohort study in Western Nepal
Authors: Khanal Vishnu 
Published: September 2023

AbstractBackground and AimsBreastfeeding education and support have the potential to improve breastfeeding outcomes. However, there is a lack of research on the impact of breastfeeding education on predominant breastfeeding in Nepal and other South Asian countries. This study aimed to report the rate of predominant breastfeeding at the first, fourth, and sixth months of birth and examine the influence of breastfeeding promotion on predominant breastfeeding.MethodsA community‐based prospective cohort study was conducted in western Nepal. A total of 735 mother‐infant pairs were recruited within 30 days of childbirth and followed up at the fourth and sixth months to collect data on infant feeding practices.ResultsThe rate of predominant breastfeeding at first, fourth, and sixth months were 88.6% (N = 735), 78.2% (N = 715), and 26.3% (N = 711), respectively, showing a significant decline with infant age. Mothers who received support on breastfeeding skills (Adjusted Odds Ratio [AOR]: 2.55; 95% confidence interval [CI]: 1.73−3.75), those who received advice on keeping mother‐infant together (AOR: 2.19; 95% CI: 1.14−4.22) and who had initiated breastfeeding within 1 h of childbirth (AOR: 2.55; 95% CI: 1.73−3.75), and who were educated, had higher likelihood of predominant breastfeeding at sixth month.ConclusionThis study asserts a need for continuous and focused breastfeeding promotion programs to educate and support lactating mothers.
Functions and Pathological Dysfunctions of RNA and Proteins: ICS Symposium Honoring Wolf Prize Laureates Chuan He, Jeffrey W. Kelly, and Hiroaki Suga: June 14, 2023, The Weizmann Institute of Science, Rehovot, Israel
Authors: Keinan Ehud 
Published: September 2023

AbstractThe Annual Wolf Prize Symposia of the Israel Chemical Society (ICS) have become a significant component of the scientific landscape of the State of Israel. These highly attended events occur annually in late May or early June as part of the Wolf Prize week, usually one day before the award ceremony in the Knesset. This account covers the one‐day symposium at the Weizmann Institute of Science on June 14, 2023, the Wolf Prize ceremony in the Knesset on June 15, and several other events in Israel that week, all honoring Chuan He, Jeffrey W. Kelly, and Hiroaki Suga.
Circ_0071589 contributes to growth, angiogenesis, and metastasis of colorectal cancer through regulating miR‐296‐5p/EN2 axis
Authors: Tang Shiyu , Kong Pengfei , Li Qian , Tang Xuegui 
Published: September 2023

AbstractTo explore the function and regulation mechanism of circ_0071589 in colorectal cancer (CRC). The expression levels of circ_0071589, microRNA‐296‐5p (miR‐296‐5p), and Engrailed‐2 (EN2) were detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). Western blot was performed to check the protein levels of EN2 and apoptosis‐related proteins. Cell colony formation and 5‐Ethynyl‐29‐deoxyuridine (EdU) assay were used to exhibit cell proliferation. Cell apoptosis was shown by flow cytometry. Tube formation assay manifested the angiogenesis ability of CRC cells. Transwell assay demonstrated cell migration and invasion. The interaction between miR‐296‐5p and circ_0071589 or EN2 was identified by dual‐luciferase reporter assay. The effect of circ_0071589 on tumor formation was demonstrated by in vivo tumor formation experiments. Immunohistochemical (IHC) assay was used to detect the positive cell rate of Ki67 in tumor tissue. Circ_0071589 was upregulated in CRC tissue and cells. Circ_0071589 knockdown repressed CRC cells proliferation, angiogenesis, migration, invasion, and promoted cell apoptosis. MiR‐296‐5p was downregulated in CRC tissue and cells. And miR‐296‐5p inhibitor could reverse the malignant phenotypes and angiogenesis inhibition of CRC cells caused by circ_0071589 knockdown. Additionally, miR‐296‐5p decreased CRC cell colony formation, EdU‐positive cells, angiogenesis, and increased cell apoptosis through reducing the expression level of EN2. Finally, circ_0071589 silencing inhibited tumor formation in vivo. Circ_0071589 upregulated EN2 expression through sponging miR‐296‐5p, thereby promoting the malignant phenotype and angiogenesis of CRC cells, which provided a new target for the treatment of CRC.
Radiation induces long‐term muscle fibrosis and promotes a fibrotic phenotype in fibro‐adipogenic progenitors
Authors: Collao Nicolas , D'Souza Donna , Messeiller Laura , Pilon Evan , Lloyd Jessica , Larkin Jillian , Ngu Matthew , Cuillerier Alexanne , Green Alexander E. , Menzies Keir J. , Burelle Yan , De Lisio Michael 
Published: September 2023

AbstractBackgroundRadiation‐induced muscle pathology, characterized by muscle atrophy and fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic radiation exposure particularly in juvenile cancer survivors. In healthy muscle, fibro/adipogenic progenitors (FAPs) are required for muscle maintenance and regeneration, while in muscle pathology FAPs are precursors for exacerbated extracellular matrix deposition. However, the role of FAPs in radiation‐induced muscle pathology has not previously been explored.MethodsFour‐week‐old Male CBA or C57Bl/6J mice received a single dose (16 Gy) of irradiation (IR) to a single hindlimb with the shielded contralateral limb (CLTR) serving as a non‐IR control. Mice were sacrificed 3, 7, 14 (acute IR response), and 56 days post‐IR (long‐term IR response). Changes in skeletal muscle morphology, myofibre composition, muscle niche cellular dynamics, DNA damage, proliferation, mitochondrial respiration, and metabolism and changes in progenitor cell fate where assessed.ResultsJuvenile radiation exposure resulted in smaller myofibre cross‐sectional area, particularly in type I and IIA myofibres (P < 0.05) and reduced the proportion of type I myofibres (P < 0.05). Skeletal muscle fibrosis (P < 0.05) was evident at 56 days post‐IR. The IR‐limb had fewer endothelial cells (P < 0.05) and fibro‐adipogenic progenitors (FAPs) (P < 0.05) at 56 days post‐IR. Fewer muscle satellite (stem) cells were detected at 3 and 56 days in the IR‐limb (P < 0.05). IR induced FAP senescence (P < 0.05), increased their fibrogenic differentiation (P < 0.01), and promoted their glycolytic metabolism. Further, IR altered the FAP secretome in a manner that impaired muscle satellite (stem) cell differentiation (P < 0.05) and fusion (P < 0.05).ConclusionsOur study suggests that following juvenile radiation exposure, FAPs contribute to long‐term skeletal muscle atrophy and fibrosis. These findings provide rationale for investigating FAP‐targeted therapies to ameliorate the negative late effects of radiation exposure in skeletal muscle.
Bioinformatics‐based analysis of programmed cell death pathway and key prognostic genes in gastric cancer: Implications for the development of therapeutics
Authors: Huang Lv , Xiong Wei , Cheng Ling , Li Haoguang 
Published: September 2023

AbstractBackgroundGastric cancer (GC) represents a major global health burden as a result of its high incidence and poor prognosis. The present study examined the role of the programmed cell death (PCD) pathway and identified key genes influencing the prognosis of patients with GC.MethodsBioinformatics analysis, machine learning techniques and survival analysis were systematically integrated to identify core prognostic genes from the The Cancer Genome Atlas Stomach Adenocarcinoma (TCGA‐STAD) dataset. A prognostic model was then developed to stratify patients into high‐risk and low‐risk groups, and further validated in the GSE84437 dataset. The model also demonstrated clinical relevance with tumor staging and histopathology. Immune infiltration analysis and the potential benefits of immunotherapy for each risk group were assessed. Finally, subgroup analysis was performed based on the expression of three key prognostic genes.ResultsThree core prognostic genes (CAV1, MMP9 and MAGEA3) were identified. The prognostic model could effectively differentiate patients into high‐risk and low‐risk groups, leading to significantly distinct survival outcomes. Increased immune cell infiltration was observed in the high‐risk group, and better potential for immunotherapy outcomes was observed in the low‐risk group. Pathways related to cancer progression, such as epithelial–mesenchymal transition and tumor necrosis factor‐α signaling via nuclear factor‐kappa B, were enriched in the high‐risk group. By contrast, the low‐risk group showed a number of pathways associated with maintenance of cell functionality and immune responses. The two groups differed in gene mutation patterns and drug sensitivities. Subgroup analysis based on the expression of the three key genes revealed two distinct clusters with distinct survival outcomes, tumor immune microenvironment characteristics and pathway enrichment.ConclusionsThe present study offers novel insights into the significance of PCD pathways and identifies key genes associated with the prognosis of patients with GC. This robust prognostic model, along with the delineation of distinct risk groups and molecular subtypes, provides valuable tools for risk stratification, treatment selection and personalized therapeutic interventions for GC.
An efficient organopromotor L‐arginine facilitated synthesis of thiazolo[3,2‐a]pyrimidine derivatives in EtOH:H2O solvent
Authors: Sharma Amit Kumar , Jaiswal Anjali , Mishra Anu , Jaiswal Shweta , Tripathi Bartendu Pati , Singh Jaya , Singh Jagdamba 
Published: September 2023

AbstractAn efficient, one pot, multicomponent, L‐arginine catalyzed synthesis of thiazolo[3,2‐a]pyrimidines is described. L‐arginine is an easily available, biodegradable, inexpensive, promising bio‐organic molecule. The current strategy is the first example of amino acid promoted, green synthesis of a series of thiazolo[3,2‐a]pyrimidines via the formation of CN and CC bonds. The major advantages of the present methodology such as recyclability of catalyst, operational simplicity, easy scale‐up, wide substrate scope, easy work‐up, inexpensive, excellent yields, and high atom economy make it a distinct improvement over the prevailing strategies.
Estimating red deer population size using vantage point counts at baited sites
Authors: Dijkhuis Laurens R. , Jansen Patrick A. , den Ouden Jan , Van Os Victor A. , Leidekker Jakob R. K. , Krul Leontien , de Jong Joost F. 
Published: September 2023

AbstractAccurate estimates of population size are central to the management and conservation of wild ungulates. Counting animals from vantage points of baited sites is a method that is traditionally used in Europe to obtain abundance estimates of wild ungulates, but its reliability in forested landscapes is contested. We assessed the accuracy of vantage point counts (VPCs) for estimating population size in red deer (Cervus elaphus) at De Hoge Veluwe National Park, a fenced, partially forested game reserve in the Netherlands. We compared estimates from duplicated VPCs for 1977–2010 with population sizes reconstructed from cohort analyses of age‐specific mortality records, including and excluding supplementation with vehicular direct counts (VDCs) and field knowledge on herd composition and herd size from game wardens. Estimates from VPCs supplemented with VDCs matched the reconstructed population size well for 2001–2010. In addition, estimates based on ≥1 VPC site/11 km2 provided representative estimates of the reconstructed population size in that period. Simultaneous VPCs at multiple baited sites can yield precise population estimates for red deer in forests.
Palate shape is associated with Unilateral Hypoglossal Nerve Stimulation Outcomes
Authors: Kedarisetty Suraj , Sharma Abhay , Commesso Emily A. , Woodson B. Tucker , Huyett Phillip , Kent David T. , D'Agostino Mark A. , Green Katherine K. , Kezirian Eric J. 
Published: September 2023

ObjectiveThe aim was to determine the potential association between palate shape and unilateral hypoglossal nerve stimulation (HNS) outcomes.MethodsPreoperative drug‐induced sleep endoscopy (DISE) videos were reviewed and scored by 3 blinded reviewers to determine airway narrowing at the hard‐soft palate junction (HP), soft palate genu, and inferior velum, as described by Woodson (2014). Scoring was as follows: 1–open airway, 2–narrow, 3–severe narrowing. Overall palate shape (oblique, intermediate, or vertical) was determined based on prior criteria. Successful surgical treatment was defined by the HNS titration polysomnogram as a reduction of ≥50% in the apnea‐hypopnea index (AHI) to <15 events/h.ResultsOf 332 adults, the majority was male (77%) with an average BMI of 29.2 ± 3.6 kg/m2. Overall success rate was 73%. Success rate was lower in patients with vertical palate shape compared with the other shapes (56% vs. 75%, p = 0.029). HP score 3 compared with scores 2 and 1 was associated with lower success rates (60% vs. 76%, p = 0.028), but genu and velum scores were not associated with outcomes. Patients with both HP score 3 and complete oropharyngeal lateral wall‐related obstruction had notably worse outcomes (22% vs. 74%, p = 0.026). HP score 3 (OR 0.45, 95%CI 0.22–0.92) and vertical palate shape (OR 0.33, 95%CI 0.15–0.78) were independently associated with lower odds of surgical response after adjustment for DISE findings, age, gender, and BMI.ConclusionVertical palate shape and narrowing at the hard‐soft palate junction are independently associated with lower HNS surgical success rates.Level of Evidence3 Laryngoscope, 134:981–986, 2024
An Autopsy Series of Seven Cases of VPS13A Disease (Chorea‐Acanthocytosis)
Authors: Ditzel Ricky M. , Walker Ruth H. , Nirenberg Melissa J. , Tetlow Amber M. , Farrell Kurt , Lind‐Watson Kourtni J. , Thorn Emma L. , Dangoor Diana K. , Gordon Ronald , De Sanctis Claudia , Barton Brandon , Karp Barbara I. , Kirby Alana , Lett Debra J. , Mente Karin , Simon David K. , Velayos‐Baeza Antonio , Miltenberger‐Miltenyi Gabriel , Humphrey Jack , Crary John F. 
Published: September 2023

AbstractBackgroundVacuolar protein sorting 13 homolog A (VPS13A) disease, historically known as chorea‐acanthocytosis, is a rare neurodegenerative disorder caused by biallelic mutations in VPS13A, usually resulting in reduced or absent levels of its protein product, VPS13A. VPS13A localizes to contact sites between subcellular organelles, consistent with its recently identified role in lipid transfer between membranes. Mutations are associated with neuronal loss in the striatum, most prominently in the caudate nucleus, and associated marked astrogliosis. There are no other known disease‐specific cellular changes (eg, protein aggregation), but autopsy reports to date have been limited, often lacking genetic or biochemical diagnostic confirmation.ObjectiveThe goal of this study was to characterize neuropathological findings in the brains of seven patients with VPS13A disease (chorea‐acanthocytosis).MethodsIn this study, we collected brain tissues and clinical data from seven cases of VPS13A for neuropathological analysis. The clinical diagnosis was confirmed by the presence of VPS13A mutations and/or immunoblot showing the loss or reduction of VPS13A protein. Tissues underwent routine, special, and immunohistochemical staining focused on neurodegeneration. Electron microscopy was performed in one case.ResultsGross examination showed severe striatal atrophy. Microscopically, there was neuronal loss and astrogliosis in affected regions. Luxol fast blue staining showed variable lipid accumulation with diverse morphology, which was further characterized by electron microscopy. In some cases, rare degenerating p62‐ and ubiquitin‐positive cells were present in affected regions. Calcifications were present in four cases, being extensive in one.ConclusionsWe present the largest autopsy series of biochemically and genetically confirmed VPS13A disease and identify novel histopathological findings implicating abnormal lipid accumulation. © 2023 International Parkinson and Movement Disorder Society.
Dopamine Transporter Availability in Early Parkinson's Disease is Dependent on Sunlight Exposure
Authors: Booij Jan , Tellier Sem P. , Seibyl John , Vriend Chris 
Published: September 2023

AbstractBackgroundPreliminary studies suggested seasonality of dopaminergic functioning, but it is unknown whether dopamine transporter (DAT) expression in humans is also dependent on the seasons. We, therefore, investigated seasonal and sunlight‐dependent effects on DAT availability in early Parkinson's disease (PD) patients and healthy controls.MethodsDAT single‐photon emission computed tomography scans (n = 730) were gathered from the Parkinson's Progression Marker Initiative (PPMI) database. We used global horizontal irradiance (GHI) as proxy for sun exposure/month and assessed associations between striatal DAT availability and season (autumn/winter versus spring/summer), GHI and latitude of the PPMI site.ResultsIn PD patients, DAT availability in the left caudate nucleus was higher in spring/summer (B [standard error (SE)] = 0.05 [0.02], P = 0.03) and positively associated with higher sun exposure (B [SE] = 0.59 [0.22] × 10−3, P = 0.007). Latitude (in degrees north) of the PPMI site was negatively associated with DAT availability in both PD and healthy controls.ConclusionStriatal DAT availability may be influenced by daylight exposure. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Modeling diameter of jet grouting columns using Bayesian framework
Authors: Zhao Lin‐Shuang , Chen Yue , Wang Yanning 
Published: September 2023

AbstractThis study proposes a new model in explicit form to predict the diameter of the jet grouting column of three popular jet grouting systems (i.e., single, double, and triple). The proposed model can quantify the uncertainty associated with the prediction. Bayesian model selection was used to determine the optimal models and, the bootstrap sampling method was adopted to avoid bias in the collected database. The predictions agree well with the measured data, and the 95% credible intervals can cover almost all the measured data on the testing dataset, which indicates the robustness of the proposed model. A simple formula combined with a table was established to facilitate the engineers in applying the proposed model. The results reveal that soil type has a significant impact on diameter prediction. Uncertainty quantification can reveal possible fluctuations in column diameter and is vital to get a cost‐efficient design.
Resilience, optimism and posttraumatic growth in first‐time mothers
Authors: Zlotnick Cheryl , Manor‐Lavon Inbal 
Published: September 2023

AbstractThis study examines the association between posttraumatic growth (PTG) and two psychological attributes, resilience and optimism, in first‐time mothers, after controlling for demographic and motherhood‐related characteristics. PTG, the self‐examination triggered by life‐changing events, contains five factors: (1) relating to others, (2) new possibilities, (3) personal strength, (4) spiritual change, and (5) appreciation of life. Outcomes from studies conflict on whether PTG is associated with the two psychological attributes of resilience (the ability to resume one's life after adversity) and optimism (viewing life in a positive light). This study used a cross‐sectional design. A convenience sample of first‐time mothers whose infants were between 3 months and 1 year (N = 415) completed questionnaires containing several standardized and reliable instruments including those measuring the independent variables of resilience and optimism, and the dependent variable of PTG. A STROBE checklist guided the reporting of this study. Resilience was associated with overall PTG and four of its five factors. Optimism also was associated with overall PTG but only associated with two of its five factors. PTG profiles and squared semipartial correlations indicated that resilience had the stronger association, compared to optimism, with PTG and most of its factors. Our study's findings on the strong link between resilience and PTG suggest the need for research examining the impact of specific psychosocial nursing activities (e.g., providing emotional support; assisting others to identify their own strengths; encouraging the mobilization of one's internal resources; furnishing needed resources and referrals; and supplying health education and information), as these activities may not only promote resilience but also may contribute to PTG.