bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of influenza virus infection on lung microbiome in adults with severe pneumonia
Authors: Zhou Yiguo , Du Juan , Wu Jing-Qin , Zhu Quan-Rong , Xie Ming-Zhu , Chen Lin-Yi , Liu Ya-Qiong , Li Wei , Zhou Ting-Fa , Lu Qing-Bin 
Published: June 2023

Abstract
Background
Bacterial and viral infections are commonly implicated in the development of pneumonia. We aimed to compare the diversity and composition of lung bacteria among severe pneumonia patients who were influenza virus positive (IFVP) and influenza virus negative (IFVN).

Methods
Bronchoalveolar lavage fluid specimens were procured from patients diagnosed with severe pneumonia to investigate the microbiome utilizing 16S-rDNA sequencing. The alpha diversity of the microbiome was evaluated employing Chao1, Shannon, and Simpson indexes, while the beta diversity was assessed using principal component analysis and principal coordinate analysis. Linear discriminant analysis effect size (LEfSe) was employed to determine the taxonomic differences between the IFVP and IFVN groups.

Results
A total of 84 patients with 42 in the IFVP group and 42 in the IFVN group were enrolled. Slightly higher indexes of Shannon and Simpson were observed in the IFVP group without statistically significant difference. The dominant bacterial genera were Streptococcus, Klebsiella, Escherichia-Shigella in the IFVN group and Acinetobacter, Streptococcus, Staphylococcus in the IFVP group. Streptococcus pneumoniae and Acinetobacter baumannii were the most abundant species in the IFVN and IFVP groups, respectively. LEfSe analysis indicated a greater abundance of Klebsiella in the IFVN group.

Conclusions
Individuals with severe pneumonia infected with IFV exhibit heightened susceptibility to certain bacteria, especially Acinetobacter baumannii, and the underlying mechanism of the interaction between IFV and Acinetobacter baumannii in the progression of pneumonia needs further investigation.
Pre-exposure prophylaxis uptake for high-risk men who have sex with men in China: a multi-city cross-sectional survey
Authors: Zhang Guang , Yang Xue , Kang Wenting , Liu Tongtong , Cheng Lili , Qu Meixia , Wang Xinlun , Tang Houlin 
Published: June 2023

Abstract
Background
Pre-exposure prophylaxis (PrEP) is a proven biomedical strategy to prevent HIV transmission among men who have sex with men (MSM). Despite oral PrEP is safe and effective in MSM, the use of PrEP has been discouraging, especially in high-risk MSM. And there are no relevant studies showing the use of PrEP in high-risk MSM. The purpose of this study was to get the rate of PrEP use and the factors influencing PrEP use among high-risk MSM.

Methods
A cross-sectional study was conducted through an electronic questionnaire on the “i guardian Platform”, and “snowballing” method was used to recruit MSM in six cities in China, including Beijing, Shenzhen, Chengdu, Changsha, Jinan and Nanjing in China, from January to April 2021. Univariate and multivariate logistic regression analysis were used to analyze the factors associated with the use of PrEP among high-risk MSM who had heard about PrEP.

Results
Among the 1865 high-risk MSM who had heard of PrEP, the rates of those who were willing to use PrEP, had knowledge awareness of PrEP, and had used PrEP were 96.7%, 24.7%, and 22.4%, respectively. Multivariate logistic regression analysis of PrEP use in high-risk MSM showed that more PrEP was used by those who were 26 years or older (OR = 1.86, 95%CI 1.17 ~ 2.99), had master degree or above (OR = 2.37, 95% CI 1.21 ~ 4.72), had unstable work (OR = 1.86, 95% CI 1.16 ~ 2.96), had tested five or more HIV times in the past year (OR = 3.09, 95% CI 1.65 ~ 6.04), had consulted PrEP (OR = 22.05, 95% CI 14.87 ~ 33.91) and had PrEP knowledge awareness (OR = 1.90, 95% CI 1.41 ~ 2.55) (P < 0.05).

Conclusions
The rate of PrEP use in high-risk MSM was relatively low. PrEP was used more by high-risk MSM with unstable jobs, higher education, frequent HIV testing, and PrEP counseling. Public education on PrEP for MSM should continue to be enhanced to help them use PrEP in a timely and accurate manner.
Frequency estimation for underwater CW pulse by interpolation on fractional Fourier coefficients based on amplitude ratio method
Authors: Li Lin , Yin JingWei , Han Xiao , Ge Wei 
Published: June 2023

AbstractFast and accurate estimation of sinusoidal signals plays an important role in many fields like communications, radar, sonar, etc. In underwater signal processing applications, sinusoidal signals usually take the form of CW pulses in most practical applications, therefore, zero-padding and duty-cycle show their great importance to the estimation of sinusoidal signals. In this paper, a high-precision estimation algorithm of sinusoidal signal is proposed, which combines amplitude ratio algorithm and fractional Fourier coefficient interpolation algorithm. The proposed algorithm uses the adjacent spectral line ratio algorithm instead of the Fourier coefficient maximum amplitude discrete spectral line search algorithm for coarse estimation, and modifies the traditional interpolation method. The proposed algorithm improves the Fourier coefficient interpolation algorithm by combining zero-padded signals to achieve the accurate frequency estimation for zero-padded sinusoidal signal. The performance of the algorithm is also in accordance with theoretical level for zero-padded signals, which is a great improvement over the frequency estimation algorithm for non-padded signals as well as the algorithm for zero-padding signals. The theoretical results are verified by extensive computer simulations which show that the proposed algorithm can both achieve better results for zero-padding cases and maintain comparable performance with competing algorithms for the non-padded signal. Therefore, the algorithm can be better applied to practical underwater detection or communication signals.
An examination of the psychosocial consequences experienced by children and adolescents living with congenital heart disease and their primary caregivers: a scoping review protocol
Authors: Dorfman Tamara L. , Archibald Mandy , Haykowsky Mark , Scott Shannon D. 
Published: June 2023

Abstract
Background
The chronicity of congenital heart disease (CHD) comes with significant psychosocial consequences for both children and adolescents living with CHD and their primary caregivers. Children and adolescents living with CHD undergo multiple traumatizing invasive surgical and medical procedures, struggle with disabilities resulting from their CHD, face unfair scrutiny and marginalization, and are at risk for mental health issues. Primary caregivers of children and adolescents living with CHD deal with increased stress, fear, anxiety, depression, and financial burden. The overarching objectives of this scoping review are to (1) determine the current state of knowledge on negative psychosocial consequences experienced by children and adolescents living with CHD and their primary caregivers in high-income countries and (2) inform research aimed at developing interventions in high-income countries to decrease the negative psychosocial consequences experienced by children and adolescents living with CHD and their primary caregivers.

Methods
Databases and grey literature searched will include MEDLINE, CINAHL, EMBASE, PsycINFO, CENTRAL, Scopus, ProQuest Theses and Dissertations, and Google advanced search. Citation mining of included studies and relevant review articles will be completed. Studies will be screened by title and abstract and then full text by two independent reviewers, using pre-defined inclusion and exclusion criteria. Quality analysis will be conducted on all included studies by two reviewers using MMAT Version 2018. Studies will not be excluded due to quality assessment. Data from all eligible studies will be independently extracted by the two reviewers and verified by consensus. Data will be presented and synthesized in evidence tables to examine potential patterns.

Discussion
The results of this review will provide recognition of the psychosocial impact of CHD and its treatments on children and adolescents living with CHD and their primary caregivers. It will also highlight interventions that have been developed to decrease these psychosocial consequences. The results from this review will inform a future integrated knowledge translation study by the first author aimed at decreasing one or more of the negative psychosocial consequences experienced by children or adolescents living with CHD and their primary caregivers.

Systematic review registration
Open Science Framework (OSF) Registration, https://doi.org/10.17605/OSF.IO/ZXYGW
Successes, weaknesses, and recommendations to strengthen primary health care: a scoping review
Authors: Endalamaw Aklilu , Erku Daniel , Khatri Resham B. , Nigatu Frehiwot , Wolka Eskinder , Zewdie Anteneh , Assefa Yibeltal 
Published: June 2023

Abstract
Background
Primary health care (PHC) is a roadmap for achieving universal health coverage (UHC). There were several fragmented and inconclusive pieces of evidence needed to be synthesized. Hence, we synthesized evidence to fully understand the successes, weaknesses, effective strategies, and barriers of PHC.

Methods
We followed the PRISMA extension for scoping reviews checklist. Qualitative, quantitative, or mixed-approach studies were included. The result synthesis is in a realistic approach with identifying which strategies and challenges existed at which country, in what context and why it happens.

Results
A total of 10,556 articles were found. Of these, 134 articles were included for the final synthesis. Most studies (86 articles) were quantitative followed by qualitative (26 articles), and others (16 review and 6 mixed methods). Countries sought varying degrees of success and weakness. Strengths of PHC include less costly community health workers services, increased health care coverage and improved health outcomes. Declined continuity of care, less comprehensive in specialized care settings and ineffective reform were weaknesses in some countries. There were effective strategies: leadership, financial system, ‘Diagonal investment’, adequate health workforce, expanding PHC institutions, after-hour services, telephone appointment, contracting with non-governmental partners, a ‘Scheduling Model’, a strong referral system and measurement tools. On the other hand, high health care cost, client’s bad perception of health care, inadequate health workers, language problem and lack of quality of circle were barriers.

Conclusions
There was heterogeneous progress towards PHC vision. A country with a higher UHC effective service coverage index does not reflect its effectiveness in all aspects of PHC. Continuing monitoring and evaluation of PHC system, subsidies to the poor, and training and recruiting an adequate health workforce will keep PHC progress on track. The results of this review can be used as a guide for future research in selecting exploratory and outcome parameters.
The prevalence of hyperglycemia and its association with perioperative outcomes in gynecologic surgery: a retrospective cohort study
Authors: Chaves Katherine F. , Panza Joseph R. , Olorunfemi Mutiya A. , Helou Christine M. , Apple Annie N. , Zhao Zhiguo , Sorabella Laura L. , Dumas Susan D. , Adam Rony A. , Prescott Lauren S. 
Published: June 2023

Abstract
Background
Preoperative hyperglycemia has been associated with perioperative morbidity in general surgery patients. Additionally, preoperative hyperglycemia may indicate underlying impaired glucose metabolism. Thus, identification of preoperative hyperglycemia may provide an opportunity to mitigate both short-term surgical and long-term health risk. We aimed to study this phenomenon specifically in the gynecologic surgery population. Specifically, we aimed to evaluate the association between preoperative hyperglycemia and perioperative complications in gynecologic surgery patients and to characterize adherence to diabetes screening guidelines.

Methods
This retrospective cohort study included 913 women undergoing major gynecologic surgery on an enhanced recovery pathway from January 2018 to July 2019. The main exposure was day of surgery glucose ≥ 140 g/dL. Multivariate regression identified risk factors for hyperglycemia and composite and wound-specific complications.

Results
Sixty-seven (7.3%) patients were hyperglycemic. Diabetes (aOR 24.0, 95% CI 12.3–46.9, P < .001) and malignancy (aOR 2.3, 95% CI 1.2–4.5, P = .01) were associated with hyperglycemia. Hyperglycemia was not associated with increased odds of composite perioperative (aOR 1.3, 95% CI 0.7–2.4, P = 0.49) or wound-specific complications (aOR 1.1, 95% CI 0.7–1.5, P = 0.76). Of nondiabetic patients, 391/779 (50%) met the USPSTF criteria for diabetes screening; 117 (30%) had documented screening in the preceding 3 years. Of the 274 unscreened patients, 94 (34%) had day of surgery glucose levels suggestive of impaired glucose metabolism (glucose ≥ 100 g/dL).

Conclusion
In our study cohort, the prevalence of hyperglycemia was low and was not associated with higher risk of composite or wound-specific complications. However, adherence to diabetes screening guidelines was poor. Future studies should aim to develop a preoperative blood glucose testing strategy that balances the low utility of universal glucose screening with the benefit of diagnosing impaired glucose metabolism in at-risk individuals.
The direct prognosis comparison of 125I low-dose-rate brachytherapy versus laparoscopic radical prostatectomy for patients with intermediate-risk prostate cancer
Authors: Liang Zhen , Yuliang Chen , Zhu Ming , Zhou Yi , Wu Xingcheng , Li Hanzhong , Fan Bu , Zhou Zhien , Yan Weigang 
Published: June 2023

Abstract
Background
This study aims to compare the clinical outcomes after performing radical prostatectomy (RP) or low-dose-rate brachytherapy (LDR) for patients with intermediate-risk prostate cancer (IRPC).

Methods
We performed a retrospective analysis on 361 IRPC patients who underwent treatment in Peking Union Medical College Hospital from January 2014 to August 2021, of which 160 underwent RP and 201 underwent Iodine-125 LDR. Patients were followed in clinic monthly during the first three months and at three-month intervals thereafter. Univariate and multivariate regression analyses were conducted to predict biochemical relapse-free survival (bRFS), clinical relapse-free survival (cRFS), cancer-specific survival (CSS), and overall survival (OS). Biochemical recurrence was defined using the Phoenix definition for LDR and the surgical definition for RP. The log-rank test was applied to compare bRFS between the two modalities, and Cox regression analysis was performed to identify factors associated with bRFS.

Results
Median follow-up was 54 months for RP and 69 months for LDR. According to log-rank test, the differences of 5-year bRFS (70.2% vs 83.2%, P = 0.003) and 8-year bRFS (63.1% vs 68.9%, P < 0.001) between RP and LDR groups were statistically significant. Our results also indicated that there was no significant difference in terms of cRFS, CSS, or OS between the two groups. With multivariate analysis of the entire cohort, prostate volume ≤ 30 ml (P < 0.001), positive margin (P < 0.001), and percentage positive biopsy cores > 50% (P < 0.001) were independent factors suggestive of worse bRFS.

Conclusions
LDR is a reasonable treatment option for IRPC patients, yielding improved bRFS and equivalent rates of cRFS, CSS and OS when compared with RP.
Potential non-invasive biomarkers in tumor immune checkpoint inhibitor therapy: response and prognosis prediction
Authors: Song Ruixia , Liu Fengsen , Ping Yu , Zhang Yi , Wang Liping 
Published: June 2023

AbstractImmune checkpoint inhibitors (ICIs) have dramatically enhanced the treatment outcomes for diverse malignancies. Yet, only 15–60% of patients respond significantly. Therefore, accurate responder identification and timely ICI administration are critical issues in tumor ICI therapy. Recent rapid developments at the intersection of oncology, immunology, biology, and computer science have provided an abundance of predictive biomarkers for ICI efficacy. These biomarkers can be invasive or non-invasive, depending on the specific sample collection method. Compared with invasive markers, a host of non-invasive markers have been confirmed to have superior availability and accuracy in ICI efficacy prediction. Considering the outstanding advantages of dynamic monitoring of the immunotherapy response and the potential for widespread clinical application, we review the recent research in this field with the aim of contributing to the identification of patients who may derive the greatest benefit from ICI therapy.
Measurement in STEM education research: a systematic literature review of trends in the psychometric evidence of scales
Authors: Maric Danka , Fore Grant A. , Nyarko Samuel Cornelius , Varma-Nelson Pratibha 
Published: June 2023

Abstract
Background
The objective of this systematic review is to identify characteristics, trends, and gaps in measurement in Science, Technology, Engineering, and Mathematics (STEM) education research.

Methods
We searched across several peer-reviewed sources, including a book, similar systematic reviews, conference proceedings, one online repository, and four databases that index the major STEM education research journals. We included empirical studies that reported on psychometric development of scales developed on college/university students for the context of post-secondary STEM education in the US. We excluded studies examining scales that ask about specific content knowledge and contain less than three items. Results were synthesized using descriptive statistics.

Results
Our final sample included the total number of N = 82 scales across N = 72 studies. Participants in the sampled studies were majority female and White, most scales were developed in an unspecified STEM/science and engineering context, and the most frequently measured construct was attitudes. Internal structure validity emerged as the most prominent validity evidence, with exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) being the most common. Reliability evidence was dominated by internal consistency evidence in the form of Cronbach’s alpha, with other forms being scarcely reported, if at all.

Discussion
Limitations include only focusing on scales developed in the United States and in post-secondary contexts, limiting the scope of the systematic review. Our findings demonstrate that when developing scales for STEM education research, many types of psychometric properties, such as differential item functioning, test–retest reliability, and discriminant validity are scarcely reported. Furthermore, many scales only report internal structure validity (EFA and/or CFA) and Cronbach’s alpha, which are not enough evidence alone. We encourage researchers to look towards the full spectrum of psychometric evidence both when choosing scales to use and when developing their own. While constructs such as attitudes and disciplines such as engineering were dominant in our sample, future work can fill in the gaps by developing scales for disciplines, such as geosciences, and examine constructs, such as engagement, self-efficacy, and perceived fit.
Evaluation of reconstruction methods and image noise levels concerning visual assessment of simulated liver lesions in 111In-octreotide SPECT imaging
Authors: Wikberg Emma , van Essen Martijn , Rydén Tobias , Svensson Johanna , Gjertsson Peter , Bernhardt Peter 
Published: June 2023

Abstract
Background
Early cancer detection is crucial for patients’ survival. The image quality in 111In-octreotide SPECT imaging could be improved by using Monte Carlo (MC)-based reconstruction. The aim of this observational study was to determine the detection rate of simulated liver lesions for MC-based ordered subset expectation maximization (OSEM) reconstruction compared to conventional attenuation-corrected OSEM reconstruction.

Methods
Thirty-seven SPECT/CT examinations with 111In-octreotide were randomly selected. The inclusion criterion was no liver lesions at the time of examination and for the following 3 years. SPECT images of spheres representing lesions were simulated using MC. The raw data of the spheres were added to the raw data of the established healthy patients in 26 of the examinations, and the remaining 11 examinations were not modified. The images were reconstructed using conventional OSEM reconstruction with attenuation correction and post filtering (fAC OSEM) and MC-based OSEM reconstruction without and with post filtering (MC OSEM and fMC OSEM, respectively). The images were visually and blindly evaluated by a nuclear medicine specialist. The criteria evaluated were liver lesion yes or no, including coordinates if yes, with confidence level 1–3. The percentage of detected lesions and accuracy (percentage of correctly classified cases), as well as tumor-to-normal tissue concentration (TNC) ratios and signal-to-noise ratios (SNRs), were evaluated.

Results
The detection rates were 30.8% for fAC OSEM, 42.3% for fMC OSEM, and 50.0% for MC OSEM. The accuracies were 45.9% for fAC OSEM, 45.9% for fMC OSEM, and 54.1% for MC OSEM. The number of false positives was higher for fMC and MC OSEM. The observer’s confidence level was higher in filtered images than in unfiltered images. TNC ratios were significantly higher, statistically, with MC OSEM and fMC OSEM than with AC OSEM, but SNRs were similar due to higher noise with MC OSEM.

Conclusion
One in two lesions were found using MC OSEM versus one in three using conventional reconstruction. TNC ratios were significantly improved, statistically, using MC-based reconstruction, but the noise levels increased and consequently the confidence level of the observer decreased. For further improvements, image noise needs to be suppressed.
Intraperitoneal hemorrhage secondary to ruptured omental artery aneurysm associated with polyarteritis nodosa: a case report
Authors: El-Farra Mohamed H. , Yahia Rayan , Cetinkaya Aysenur , Hasaniya Nahidh 
Published: June 2023

Abstract
Background
Polyarteritis nodsa (PAN) is a rare disease characterized by acute focal inflammatory damage to small and medium arteries. PAN complicated by ruptured aneurysm is an infrequent presentation with the most affected arteries being the renal and mesenteric arteries.

Case presentation
A 76-year-old female presented with a low-grade fever, generalized body aches, and abdominal pain. Investigation revealed intraperitoneal bleeding secondary to a ruptured and actively bleeding right omental artery aneurysm. Clinical manifestation, angiography and histology were consistent with PAN. Laparotomy was performed for stabilization and resection of the bleeding aneurysm followed by post operative steroids and cyclophosphamide. Patient was discharged in a stable condition. We reviewed seven cases found in the literature of omental artery aneurysm and rupture. Four cases were proceeded with laparotomy and aneurysm resection while three cases were proceeded with a less invasive approach of arterial embolization.

Conclusions
Omental artery aneurysm is a rare occurrence with even fewer reported cases associated with PAN. Of the seven reported cases, all patients were treated with a surgical intervention. In addition, PAN patients should be treated post-operatively with a course of steroids and cyclophosphamide.