bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK
Authors: Nussinov Ruth , Yavuz Bengi Ruken , Arici M Kaan , Demirel Habibe Cansu , Zhang Mingzhen , Liu Yonglan , Tsai Chung-Jung , Jang Hyunbum , Tuncbag Nurcan 
Published: April 2023

AbstractNeurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and mutations. Their clinical symptoms are different. However, individuals with NDDs have higher probabilities of eventually developing cancer. Here, we review the literature and ask how the shared features can lead to different medical conditions and why having an NDD first can increase the chances of malignancy. To explore these vital questions, we focus on dysregulated PI3K/mTOR, a major brain cell growth pathway in differentiation, and MAPK, a critical pathway in proliferation, a hallmark of cancer. Differentiation is governed by chromatin organization, making aberrant chromatin remodelers highly likely agents in NDDs. Dysregulated chromatin organization and accessibility influence the lineage of specific cell brain types at specific embryonic development stages. PAK1, with pivotal roles in brain development and in cancer, also regulates MAPK. We review, clarify, and connect dysregulated pathways with dysregulated proliferation and differentiation in cancer and NDDs and highlight PAK1 role in brain development and MAPK regulation. Exactly how PAK1 activation controls brain development, and why specific chromatin remodeler components, e.g., BAF170 encoded by SMARCC2 in autism, await clarification.
Ovarian clear cell carcinoma with or without endometriosis origin in a single institution cohort
Authors: Sun Mingming , Jiang Wei 
Published: April 2023

Abstract
Background
As ovarian clear cell carcinoma (OCCC) has distinct clinical features, biology, genetic characteristics and mechanisms of pathogenesis, and whether the origin of endometriosis or not affects the prognosis of OCCC remains controversial.

Methods
We retrospectively collected medical records and follow-up data of patients with OCCC treated at the Obstetrics and Gynecology Hospital of Fudan University from January 2009 to December 2019. Further, we divided patients into 2 groups. Group 1: non-endometriosis origin; Group 2: endometriosis origin. Clinicopathological characteristics and survival outcomes were compared between the 2 groups.

Results
A total of one hundred and twenty-five patients with ovarian clear cell carcinoma were identified and included. In the overall patients’ population, the 5 year overall survival was 84.8%, the mean overall survival was 85.9 months. The results of the stratified analysis showed that early stage (FIGO stage I/II) OCCC had a good prognosis. The results of univariate analyses indicated that a statistically significant relationship between overall survival (OS) and FIGO stage, lymph node metastasis, peritoneum metastasis, chemotherapy administration methods, Chinese herbal treatment, molecular target therapy. As for progression-free survival (PFS), a significant relationship between PFS and child-bearing history, largest residual tumor size, FIGO stage, tumor maximum diameter, lymph node metastasis was found, respectively. FIGO stage and lymph node metastasis are common poor prognostic factors affecting OS and PFS. The multivariate regression analysis revealed that FIGO stage (p = 0.028; HR, 1.944; 95% CI 1.073–3.52) and treatment by Chinese herbs (p = 0.018; HR, 0.141; 95% CI 0.028–0.716) were identified as influencing factors with regard to survival. The presence or absence of lymphadenectomy did not affect OS of 125 OCCC patients (p = 0.851; HR, 0.825; 95% CI 0.111–6.153).
There was a trend towards a better prognosis for patients with OCCC of endometriosis origin than those with OCCC of non-endometriosis origin (p = 0.062; HR, 0.432; 95% CI 0.179–1.045). The two groups differed with respect to several clinicopathological factors. And the proportion of patients with disease relapse was higher in Group 1 (46.9%) than in Group 2 (25.0%), with a statistically significant difference (p = 0.048).

Conclusions
Surgical staging and treatment by Chinese herbs postoperatively are two independent prognostic factors affecting the OS of OCCC, early detection and Chinese herbal medicine combined with chemotherapy postoperatively may be a good choice. Tumor with endometriosis-origin was found less likely to relapse. While the non-necessity of lymphadenectomy in advanced ovarian cancer has been proven, the need for lymphadenectomy in the early stage ovarian cancer, including early stage OCCC, still deserved to be explored.
Sulfate diffusion in coal pillar: experimental data and prediction model
Authors: Wang Min , Xi Xun , Guo Qifeng , Pan Jiliang , Cai Meifeng , Yang Shangtong 
Published: April 2023

AbstractThe stability of coal pillar dams is crucial for the long-term service of underground reservoirs storing water or heat. Chemical damage of coal dams induced by ions-attacking in coal is one of the main reasons for the premature failure of coal dams. However, the diffusion process of harmful ions in coal is far from clear, limiting the reliability and durability of coal dam designs. This paper investigates sulfate diffusion in coal pillar through experimental and analytical methods. Coal specimens are prepared and exposed to sulfate solutions with different concentrations. The sulfate concentrations at different locations and time are measured. Based on experimental data and Fick’s law, the time-dependent surface concentration of sulfate and diffusion coefficient are determined and formulated. Further, an analytical model for predicting sulfate diffusion in coal pillar is developed by considering dual time-dependent characteristics and Laplace transformations. Through comparisons with experimental data, the accuracy of the analytical model for predicting sulfate diffusion is verified. Further, sulfate diffusions in coal dams for different concentrations of sulfate in mine water are investigated. It has been found that the sulfate concentration of exposure surface and diffusion coefficient in coal are both time-dependent and increase with time. Conventional Fick’s law is not able to predict the sulfate diffusion in coal pillar due to the dual time-dependent characteristics. The sulfate attacking makes the coal dam a typical heterogeneous gradient structure. For sulfate concentrations 0.01–0.20 mol/L in mine water, it takes almost 1.5 and 4 years for sulfate ions to diffuse 9.46 and 18.92 m, respectively. The experimental data and developed model provide a practical method for predicting sulfate diffusion in coal pillar, which helps the service life design of coal dams.
Migraine drugs
Authors: Ramachanderan Raghavendra , Schramm Stefan , Schaefer Bernd 
Published: April 2023

AbstractAccording to recent studies, migraine affects more than 1 billion people worldwide, making it one of the world’s most prevalent diseases. Although this highly debilitating illness has been known since ancient times, the first therapeutic drugs to treat migraine, ergotamine (Gynergen) and dihydroergotamine (Dihydergot), did not appear on the market until 1921 and 1946, respectively. Both drugs originated from Sandoz, the world’s leading pharmaceutical company in ergot alkaloid research at the time. Historically, ergot alkaloids had been primarily used in obstetrics, but with methysergide (1-methyl-lysergic acid 1′-hydroxy-butyl-(2S)-amide), it became apparent that they also held some potential in migraine treatment. Methysergide was the first effective prophylactic drug developed specifically to prevent migraine attacks in 1959. On the basis of significantly improved knowledge of migraine pathophysiology and the discovery of serotonin and its receptors, Glaxo was able to launch sumatriptan in 1992. It was the first member from the class of triptans, which are selective 5-HT1B/1D receptor agonists. Recent innovations in acute and preventive migraine therapy include lasmiditan, a selective 5-HT1F receptor agonist from Eli Lilly, the gepants, which are calcitonin gene-related peptide (CGRP) receptor antagonists discovered at Merck & Co and BMS, and anti-CGRP/receptor monoclonal antibodies from Amgen, Pfizer, Eli Lilly, and others.
Graphical abstract
Electrochemical Kinetics Study of Ultrasound-Assisted Chalcopyrite Oxidation
Authors: Li Lin , King Aaron , Davis Krystal , Yu Ben 
Published: April 2023

AbstractUltrasound-assisted chalcopyrite leaching has been reported previously, showing a noticeable improvement in leaching kinetics. However, the effect of ultrasound on the chalcopyrite oxidation kinetics from an electrochemical perspective has not been addressed. This study examines the ultrasonic enhancement of chalcopyrite oxidation kinetics in sulfuric acid solution from both conventional leaching and electrochemistry aspects. Electrochemical techniques, including linear sweep voltammetry (LSV) and chronoamperometry (CA), were used to illustrate the kinetics of chalcopyrite ultrasound-assisted leaching. Tafel analysis by LSV showed that 20% amplitude ultrasound power had increased the chalcopyrite electrochemical dissolution rate by about 20% in both Fe3+-free and 10 mM Fe3+-containing 0.5 M sulfuric acid solution. The CA tests indicated a drastic increase in the Fe3+ reduction reaction when ultrasound was applied (20% amplitude). At 0.5 V, the Fe3+ to Fe2+ reduction current density at 30 min drastically increased from − 65.54 without ultrasound to − 1165.84 µA cm−2 with ultrasound.
Graphical Abstract
The Application of Coffee Pulp Biochar Improves the Physical, Chemical, and Biological Characteristics of Soil for Coffee Cultivation
Authors: Sánchez-Reinoso Alefsi David , Ávila-Pedraza Edgar Álvaro , Lombardini Leonardo , Restrepo-Díaz Hermann 
Published: April 2023

Abstract
A field experiment was conducted for 2 years (2019 and 2020) to determine the response to the application of Biochar (BC) obtained from the coffee pulp in combination with chemical fertilization (CF) in coffee trees. The established treatments were the edaphic application of different doses of BC (0, 4, 8, and 16 t ha−1) and levels of CF (0, 33, 66, and 100% of the nutritional requirements) on the physical (bulk density (ρa), stable aggregates), chemical (nutrient availability), and biological (respiration) properties of soil from a coffee crop. Regarding the physical properties, it was mainly observed that BC doses of 8 or 16 t ha−1 reduced ρa (0.82 and 0.83 g cm−3, respectively) and increased the aggregation status (96.5% and 96.84%, respectively) in comparison to 0 t ha−1 in 2020. The chemical properties showed that the application of 16 t ha−1 BC decreased about 60% of the exchangeable acidity (EA) compared to the control (0 t ha−1) whereas the pH (4.96 and 4.92) and organic carbon (OC) (4.41 and 4.59) were higher than in the control soil (EA: 0.58 and 0.54 meq/100 g; pH: 4.63 and 4.55; OC: 4.17 and 4.32% in 2019 and 2020, respectively). Soil respiration (biological property) strongly increased (around 50–60%) with the combination of 66% CF and BC doses between 8 and 16 t ha−1 in both years. Doses between 8 and 16 t ha−1 BC of the coffee pulp can improve the quality of soils for coffee cultivation and provide an alternative and more sustainable amendment that may help reduce chemical fertilization.
A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma
Authors: Phillips Melissa M. , Pavlyk Iuliia , Allen Michael , Ghazaly Essam , Cutts Rosalind , Carpentier Josephine , Berry Joe Scott , Nattress Callum , Feng Shenghui , Hallden Gunnel , Chelala Claude , Bomalaski John , Steele Jeremy , Sheaff Michael , Balkwill Frances , Szlosarek Peter W. 
Published: April 2023

AbstractBackgroundPegylated arginine deiminase (ADI-PEG20; pegargiminase) depletes arginine and improves survival outcomes for patients with argininosuccinate synthetase 1 (ASS1)-deficient malignant pleural mesothelioma (MPM). Optimisation of ADI-PEG20-based therapy will require a deeper understanding of resistance mechanisms, including those mediated by the tumor microenvironment. Here, we sought to reverse translate increased tumoral macrophage infiltration in patients with ASS1-deficient MPM relapsing on pegargiminase therapy.MethodsMacrophage-MPM tumor cell line (2591, MSTO, JU77) co-cultures treated with ADI-PEG20 were analyzed by flow cytometry. Microarray experiments of gene expression profiling were performed in ADI-PEG20-treated MPM tumor cells, and macrophage-relevant genetic “hits” were validated by qPCR, ELISA, and LC/MS. Cytokine and argininosuccinate analyses were performed using plasma from pegargiminase-treated patients with MPM.ResultsWe identified that ASS1-expressing macrophages promoted viability of ADI-PEG20-treated ASS1-negative MPM cell lines. Microarray gene expression data revealed a dominant CXCR2-dependent chemotactic signature and co-expression of VEGF-A and IL-1α in ADI-PEG20-treated MPM cell lines. We confirmed that ASS1 in macrophages was IL-1α-inducible and that the argininosuccinate concentration doubled in the cell supernatant sufficient to restore MPM cell viability under co-culture conditions with ADI-PEG20. For further validation, we detected elevated plasma VEGF-A and CXCR2-dependent cytokines, and increased argininosuccinate in patients with MPM progressing on ADI-PEG20. Finally, liposomal clodronate depleted ADI-PEG20-driven macrophage infiltration and suppressed growth significantly in the MSTO xenograft murine model.ConclusionsCollectively, our data indicate that ADI-PEG20-inducible cytokines orchestrate argininosuccinate fuelling of ASS1-deficient mesothelioma by macrophages. This novel stromal-mediated resistance pathway may be leveraged to optimize arginine deprivation therapy for mesothelioma and related arginine-dependent cancers.
Variational inference of ice shelf rheology with physics-informed machine learning
Authors: Riel Bryan , Minchew Brent 
Published: April 2023

AbstractFloating ice shelves that fringe the coast of Antarctica resist the flow of grounded ice into the ocean. One of the key factors governing the amount of flow resistance an ice shelf provides is the rigidity (related to viscosity) of the ice that constitutes it. Ice rigidity is highly heterogeneous and must be calibrated from spatially continuous surface observations assimilated into an ice-flow model. Realistic uncertainties in calibrated rigidity values are needed to quantify uncertainties in ice sheet and sea-level forecasts. Here, we present a physics-informed machine learning framework for inferring the full probability distribution of rigidity values for a given ice shelf, conditioned on ice surface velocity and thickness fields derived from remote-sensing data. We employ variational inference to jointly train neural networks and a variational Gaussian Process to reconstruct surface observations, rigidity values and uncertainties. Applying the framework to synthetic and large ice shelves in Antarctica demonstrates that rigidity is well-constrained where ice deformation is measurable within the noise level of the observations. Further reduction in uncertainties can be achieved by complementing variational inference with conventional inversion methods. Our results demonstrate a path forward for continuously updated calibrations of ice flow parameters from remote-sensing observations.
A spatial mutation model with increasing mutation rates
Authors: Chao Brian , Schweinsberg Jason 
Published: April 2023

AbstractWe consider a spatial model of cancer in which cells are points on the d-dimensional torus
$\mathcal{T}=[0,L]^d$
, and each cell with
$k-1$
mutations acquires a kth mutation at rate
$\mu_k$
. We assume that the mutation rates
$\mu_k$
are increasing, and we find the asymptotic waiting time for the first cell to acquire k mutations as the torus volume tends to infinity. This paper generalizes results on waiting for
$k\geq 3$
mutations in Foo et al. (2020), which considered the case in which all of the mutation rates
$\mu_k$
are the same. In addition, we find the limiting distribution of the spatial distances between mutations for certain values of the mutation rates.
EMPIRE INSIDE OUT: CELEBRATING CONSTANTINE'S VICTORIES BETWEEN ROME AND TRIER
Authors: Ross Alan J. 
Published: April 2023

AbstractThis article argues thatPanegyricus LatinusXII(9), a speech performed before Constantine in Trier in 313c.e.following his defeat of Maxentius the previous year, acted as a crucial localized act of communication to the emperor. Through a series of allusions and the careful presentation of his narrative, the orator made a case for the continued political and cultural importance of Trier within the newly expanded Constantinian empire.
Rigidity of capillary surfaces in compact 3-manifolds with strictly convex boundary
Authors: Sousa Paulo Alexandre , Batista Rondinelle Marcolino , Lima Barnabé Pessoa , Vieira Bruno Vasconcelos Mendes 
Published: April 2023

AbstractIn this paper, we obtain one sharp estimate for the length $L(\partial\Sigma)$ of the boundary $\partial\Sigma$ of a capillary minimal surface Σ2 in M3, where M is a compact three-manifolds with strictly convex boundary, assuming Σ has index one. The estimate is in term of the genus of Σ, the number of connected components of $\partial\Sigma$ and the constant contact angle θ. Making an extra assumption on the geometry of M along $\partial M$, we characterize the global geometry of M, which is saturated only by the Euclidean three-balls. For capillary stable CMC surfaces, we also obtain similar results.
HEARING SOLARIS: DAI FUJIKURA'S OPERA AND A MUSICAL APPROACH TO STANISŁAW LEM'S NOVEL
Authors: Demoz Héloïse 
Published: April 2023

AbstractAlthough many opera libretti are based on novels and short stories, only a few have used a science-fiction story as their main subject. The first opera of the Japanese composer Dai Fujikura was written in 2013–14 to a libretto by Saburo Teshigawara and is developed from Stanisław Lem's acclaimed novel Solaris (1961). By analysing passages from the score, this article will explore both the different strategies used by the composer and his librettist to create a new version of the story and the ways in which they have renewed the genre of opera.
VALENTIN SILVESTROV AND PUTIN'S WAR IN UKRAINE
Authors: Gillies Richard Louis 
Published: April 2023

AbstractThis article draws on published interviews and personal correspondence with the Ukrainian composer Valentin Silvestrov (b. 1937) to situate the development of his musical aesthetics and international reputation within the context of the Ukrainian Revolution of Dignity, the Russian annexation of Crimea and the ongoing Russian invasion of Ukraine, launched in February 2022. In particular, the article focuses on Silvestrov's use of sacred musical genres as a means of engaging directly with his contemporary political environment; it also explores the ways in which Silvestrov and his music have recently become an unequivocal symbol of defiance in the face of Russian aggression, a position that stands in stark contrast to the avowed disinterestedness in and removal from politics that characterised his works of the 1970s and 1980s.
Help-seeking and treatment delivery preferences for women experiencing perinatal anxiety symptoms
Authors: Maguire Peta N. , Bhullar Navjot , Cosh Suzanne M. , Wootton Bethany M. 
Published: April 2023

AbstractBackground:Anxiety is common during the perinatal period and despite effective treatments being available, many women with perinatal anxiety disorders experience barriers when accessing treatment.Aims:The aims of the current study were to explore women’s perceived barriers to treatment uptake; cognitive behavioural therapy (CBT) treatment delivery preferences; and the utility of the Health Belief Model (HBM) in predicting intention to seek psychological help for women with perinatal anxiety symptoms.Method:This study employed a cross-sectional design consisting of women with self-reported anxiety in the perinatal period. A total of 216 women (Mage=28.53 years;SD=4.97) participated in the study by completing a battery of online self-report measures.Results:The results indicated that the most salient barriers to accessing care were: (1) the cost of treatment, (2) wanting to solve the problem on their own, and (3) thinking the problem would go away without treatment. Group-delivered CBT was the least acceptable treatment method, while face-to-face individual CBT was the most acceptable treatment method. The HBM variables predicted approximately 35% of the variance in help-seeking intention.Discussion:This study has important implications for the delivery of psychological care in the perinatal period and may be used to improve treatment uptake.
‘It was organized from the bottom’: the response from community-based institutions during the 2014 Ebola epidemic
Authors: Franklin Sabine Iva 
Published: April 2023

AbstractWhat was the turning point in the world's largest and deadliest outbreak of the Ebola virus disease? Public health interventions tend to focus on supply-side provision of public health goods. These goods are clinical resources such as medicine or equipment. However, no nation has enough resources to ‘treat’ its way out of a widespread epidemic. Behavioural changes, such as social distancing, are needed too. Behaviours are the demand-side of public health goods and if unaddressed, perpetuate disease transmission. Community-based institutions addressed demand-side barriers during the 2014 Ebola epidemic in Liberia and Sierra Leone. Sixty-seven interviews were conducted in several provinces in Liberia and Sierra Leone. The findings show that information asymmetry and collective action challenges lowered the demand for clinical resources. Community-based institutions intervened via health sensitization and emergency regulations. Therefore, health seeking and public cooperation improved. This research study demonstrates a need to integrate community-led action into public health emergency management.
Lifetime caffeine and adolescent nicotine exposure in mice: effects on anxiety-like behavior and reward
Authors: Dutra-Tavares Ana Carolina , Ribeiro-Carvalho Anderson , Nunes Fernanda , Araújo Ulisses Cesar , Bruno Vitor , Marcourakis Tania , Filgueiras Claudio C. , Manhães Alex C. , Abreu-Villaça Yael 
Published: April 2023

AbstractCaffeine consumption occurs throughout life, while nicotine use typically begins during adolescence, the period when caffeine-nicotine epidemiological association begins in earnest. Despite that, few studies in animal models parallel the pattern of coexposure that occurs in humans. Therefore, the neurobehavioral consequences of the association between these drugs remain unclear. Here, we exposed Swiss mice to lifetime caffeine. Caffeine solutions of 0.1 g/L (CAF0.1), 0.3 g/L (CAF0.3), or water (CTRL) were used as the sole liquid source, being offered to progenitors until weaning and, after that, directly to the offspring until the last day of adolescent behavioral evaluation. The open field test was used to evaluate acute effects of nicotine, of lifetime caffeine and of their interaction on locomotion and anxiety-like behavior, while the conditioned place preference test was used to assess the impact of caffeine on nicotine (0.5 mg/Kg, i.p.) reward. Frontal cerebral cortex dopamine content, dopamine turnover, and norepinephrine levels, as well as hippocampal serotonin 1A receptor expression were assessed. CAF0.3 mice exhibited an increase in anxiety-like behavior when compared to CAF0.1 and CTRL ones, but nicotine coexposure mitigated the anxiogenic-like caffeine-induced effect. Distinctively, caffeine had no effect on locomotion and failed to interfere with both nicotine-induced hyperactivity and place preference. There were no significant effects on dopaminergic and serotonergic markers. In conclusion, although caffeine did not affect nicotine reward, considering the strong association between anxiety disorders and tobacco consumption, caffeine-induced anxiety-like behavior advises limiting its consumption during development, including adolescence, as caffeine could be a risk factor to nicotine use.