bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qing-Re-Xiao-Zheng-Yi-Qi formula relieves kidney damage and activates mitophagy in diabetic kidney disease
Authors: Wu Qiaoru , Yan Runze , Yang Hanwen , Wang Yixuan , Zhang Chao , Zhang Jiale , Cui Zhaoli , Wang Yaoxian , Sun Weiwei 
Published: December 2022

Introduction: Qing-Re-Xiao-Zheng-Yi-Qi Formula is an effective prescription in diabetic kidney disease treatment, we have confirmed the efficacy of Qing-Re-Xiao-Zheng therapy in diabetic kidney disease through clinical trials. In this study, we investigated the mechanisms of Qing-Re-Xiao-Zheng-Yi-Qi Formula in the treatment of diabetic kidney disease.Methods: We used Vanquish UHPLCTM to analyze the chemical profiling of Qing-Re-Xiao-Zheng-Yi-Qi Formula freeze-dried powder. We constructed diabetic kidney disease rat models induced by unilateral nephrectomy and high-dose streptozocin injection. We examined blood urea nitrogen, serum creatinine, serum glucose, total cholesterol, triglyceride, serum total protein, albumin, alanine aminotransferase, aspartate aminotransferase and 24 h urinary total protein in diabetic kidney disease rats. The renal pathological changes were observed by HE, Masson, PAS stanning and transmission electron microscopy. The levels of fibrosis-related proteins and mitophagy-related proteins were detected by western blot analysis. We also conducted an immunofluorescence co-localization analysis on podocytes to further investigate the effect of Qing-Re-Xiao-Zheng-Yi-Qi Formula treatment on mitophagy.Results: A total of 27 constituents in Qing-Re-Xiao-Zheng-Yi-Qi Formula were tentatively identified. We found PINK1/Parkin-mediated mitophagy was inhibited in diabetic kidney disease. Qing-Re-Xiao-Zheng-Yi-Qi Formula treatment could raise body weight and reduce renal index, reduce proteinuria, improve glycolipid metabolic disorders, ameliorate renal fibrosis, and reduce the expression of Col Ⅳ and TGF-β1 in diabetic kidney disease rats. Qing-Re-Xiao-Zheng-Yi-Qi Formula treatment could also increase the expression of nephrin, activate mitophagy and protect podocytes in diabetic kidney disease rats and high glucose cultured podocytes.Conclusion: PINK1/Parkin-mediated mitophagy was inhibited in diabetic kidney disease, and Qing-Re-Xiao-Zheng-Yi-Qi Formula treatment could not only ameliorate pathological damage, but also promote mitophagy to protect podocytes in diabetic kidney disease.
Complex effects of childhood abuse, subjective social status, and trait anxiety on presenteeism in adult volunteers from the community
Authors: Nibuya Rintaro , Shimura Akiyoshi , Masuya Jiro , Iwata Yoshio , Deguchi Ayaka , Ishii Yoshitaka , Tamada Yu , Fujimura Yota , Tanabe Hajime , Inoue Takeshi 
Published: December 2022

BackgroundPresenteeism, which is reduced productivity levels owing to physical or mental problems, causes substantial economic loss. It is known to be associated with personal and working environment factors, but the mechanism has not been fully clarified to date. Therefore, we analyzed the effects of childhood abuse on presenteeism of general adult workers, and the mediating effects of subjective social status and trait anxiety.MethodsFrom 2017 to 2018, a cross-sectional survey was performed, and 469 adult workers provided written consent. Demographic information, and results from the Child Abuse and Trauma Scale, Subjective Social Status, State–Trait Anxiety Inventory form Y, and Work Limitations Questionnaire were investigated. Multiple linear regression and path analyzes were performed.ResultsChildhood abuse indirectly affected current presenteeism via subjective social status and trait anxiety. Presenteeism was directly affected only by trait anxiety, childhood abuse directly affected subjective social status and trait anxiety, and subjective social status affected trait anxiety.ConclusionThis study clarified the long-term effects of childhood abuse on presenteeism in adulthood via trait anxiety. Therefore, assessing childhood abuse, subjective social status, and trait anxiety may help to elucidate the mechanism of workplace presenteeism and develop measures against it.
Hot spots and frontiers of postpartum depression research in the past 5 years: A bibliometric analysis
Authors: Wang Runfang , Shan Yaokun 
Published: December 2022

ObjectiveThis study applied the bibliometric method to analyze the hotspots and frontiers in the field of postpartum depression research from 2017 to 2021.MethodsA computer-based search for studies related to postpartum depression (PPD) was conducted in the Web of Science Core Collection from 2017 to 2021. Using CiteSpace 5.8. R3 visualization software, this paper analyzed the hot spots and frontiers of postpartum depression research from countries, institutions, authors, cited references and keywords, and drew corresponding knowledge maps.ResultsA total of 3,789 articles were retrieved, and the annual publication volume showed a steady increase. The countries and institutions with the most publications were the United States and the University of Toronto, respectively. Cindylee Dennis was the most productive author. The most frequently cited and centrally cited articles were meta-analyses on risk factors associated with antenatal depression or anxiety and meta-analyses on the prevalence of antenatal or postnatal anxiety, respectively. The research hotspots in the field of postpartum depression in the past 5 years mainly focused on the risk factors for PPD, and the impact of the COVID-19 epidemic on PPD. Providing various aspects of social and family support to women with PPD may be a research trend in this field.ConclusionThis study provides a trend and frontier in the field of postpartum depression, and valuable information for researchers to find potential partners and partner countries, and a reference for future research topics and development directions.
Construction and validation of nomograms combined with novel machine learning algorithms to predict early death of patients with metastatic colorectal cancer
Authors: Zhang Yalong , Zhang Zunni , Wei Liuxiang , Wei Shujing 
Published: December 2022

PurposeThe purpose of this study was to investigate the clinical and non-clinical characteristics that may affect the early death rate of patients with metastatic colorectal carcinoma (mCRC) and develop accurate prognostic predictive models for mCRC.MethodMedical records of 35,639 patients with mCRC diagnosed from 2010 to 2019 were obtained from the SEER database. All the patients were randomly divided into a training cohort and a validation cohort in a ratio of 7:3. X-tile software was utilized to identify the optimal cutoff point for age and tumor size. Univariate and multivariate logistic regression models were used to determine the independent predictors associated with overall early death and cancer-specific early death caused by mCRC. Simultaneously, predictive and dynamic nomograms were constructed. Moreover, logistic regression, random forest, CatBoost, LightGBM, and XGBoost were used to establish machine learning (ML) models. In addition, receiver operating characteristic curves (ROCs) and calibration plots were obtained to estimate the accuracy of the models. Decision curve analysis (DCA) was employed to determine the clinical benefits of ML models.ResultsThe optimal cutoff points for age were 58 and 77 years and those for tumor size of 45 and 76. A total of 15 independent risk factors, namely, age, marital status, race, tumor localization, histologic type, grade, N-stage, tumor size, surgery, radiation, chemotherapy, bone metastasis, brain metastasis, liver metastasis, and lung metastasis, were significantly associated with the overall early death rate of patients with mCRC and the cancer-specific early death rate of patients with mCRC, following which nomograms were constructed. The ML models revealed that the random forest model accurately predicted outcomes, followed by logistic regression, CatBoost, XGBoost, and LightGBM models. Compared with other algorithms, the random forest model provided more clinical benefits than other models and can be used to make clinical decisions in overall early death and specific early death caused by mCRC.ConclusionML algorithms combined with nomograms may play an important role in distinguishing early deaths owing to mCRC and potentially help clinicians make clinical decisions and follow-up strategies.
Weighing patient attributes in antibiotic prescribing for upper respiratory tract infections: A discrete choice experiment on primary care physicians in Hubei Province, China
Authors: Xue Tianqin , Liu Chaojie , Li Zhuoxian , Liu Junjie , Tang Yuqing 
Published: December 2022

ObjectivesThis study aimed to determine how primary care physicians weigh intervenable patient attributes in their decisions of antibiotic prescribing for upper respiratory tract infections (URTIs).MethodsA discrete choice experiment (DCE) was conducted on 386 primary care physicians selected through a stratified cluster sampling strategy in Hubei province, China. The patient attributes tested in the DCE were identified through semi-structured interviews with 13 primary care physicians, while the choice scenarios were determined by a D-efficient design with a zero prior parameter value. Conditional logit models (CL) and mixed logit models (MXL) were established to determine the preference of the study participants in antibiotic prescribing for URTI patients with various attributes. Relative importance (RI) was calculated to reflect the influence of each attribute.ResultsIn addition to age and duration of symptoms, the interventionable patient attributes were also considered by the primary care physicians in their antibiotic prescribing decisions. They preferred to prescribe antibiotics for URTI patients with difficulties to schedule a follow-up appointment (p &lt; 0.001) and for those without a clear indication of refusal to antibiotics (p &lt; 0.001). Patient request for antibiotics had an RI ranging from 15.2 to 16.3%, compared with 5.1–5.4% for easiness of follow-up appointment. The influence of these two interventionable patient attributes was most profound in the antibiotic prescribing decisions for patients aged between 60 and 75 years as indicated by their interaction effects with age (β = 0.69 for request for antibiotics, p &lt; 0.01; β = −1.2 for easiness of follow-up, p &lt; 0.001).ConclusionReducing patient pressure and improving accessibility and continuity of care may help primary care physicians make rational antibiotic prescribing decisions for URTIs.
Qualities of transformative leaders in WASH: A study of gender-transformative leadership during the COVID-19 pandemic
Authors: Gonzalez Diana , Carrard Naomi , Chhetri Aastha , Somphongbouthakanh Phetsakhone , Choden Tshering , Halcrow Gabrielle , Budhathoki Ratan , Wangchuk Ugyen , Willetts Juliet 
Published: December 2022

IntroductionEqual access to water, sanitation and hygiene (WASH) for all requires leadership that prioritises and drives inclusion. Inclusive WASH also presents opportunities to advance equality more widely, with WASH a pathway to meaningful participation and empowerment for diverse groups. The concept of gender-transformative leadership-which connects ideas of leadership to transformative models of gender equality in development theory that challenge prevailing power structures-is a relevant lens for exploring inclusive WASH. This article shares findings and reflections from a positive deviance study that aimed to investigate gender-transformative leadership in the WASH sector to explore (i) the factors shaping gender-transformative leadership and the characteristics of gender-transformative leaders; (ii) actions taken by gender-transformative leaders; (iii) the types of outcomes achieved; and (iv) ways to strengthen gender-transformative leadership.MethodsThe study was undertaken during the COVID-19 pandemic and consisted of interviews with 19 leaders in Bhutan, Lao People's Democratic Republic, and Nepal. We developed a conceptual framework which considers leaders' (i) personal values and traits; (ii) leadership styles; (iii) actions; and (iv) outcomes, influenced by a range of (v) enabling factors and barriers.ResultsLeaders' personal values and traits included a strong learning orientation, social justice values, humility, courage, and altruism. Leadership styles were primarily empathetic, with leaders guided by a mission to lead by example and pursue equality in their professional and personal lives. Exploration of actions and outcomes revealed a range of inclusion-oriented WASH activities responding to pandemic-related challenges, with associated potential outcomes in shifting norms. However, validation of outcomes was not possible due to the study timeframe and complexity of tracing complex social change in a positive deviance study reliant on self-reporting. Analysis of enablers and barriers to gender-transformative leadership respectively emphasized the importance of educational opportunities and the persistence of traditional gender norms.ConclusionFindings contribute to the body of knowledge on gender-transformative leadership, being the first study to connect this concept to WASH. Future research could build further evidence by applying the conceptual framework to analyze additional contexts or sectors, and by more fully articulating and validating outcomes in terms of their potential for gender-transformative leadership to drive equality both in and beyond WASH.
Up and Down h-Pre-Invex Fuzzy-Number Valued Mappings and Some Certain Fuzzy Integral Inequalities
Authors: Khan Muhammad Bilal , Zaini Hatim Ghazi , Macías-Díaz Jorge E. , Soliman Mohamed S. 
Published: December 2022

The objective of the current paper is to incorporate the new class and concepts of convexity and Hermite–Hadamard inequality with the fuzzy Riemann integral operators because almost all classical single-valued and interval-valued convex functions are special cases of fuzzy-number valued convex mappings. Therefore, a new class of nonconvex mapping in the fuzzy environment has been defined; up and down h-pre-invex fuzzy-number valued mappings (U.D h-pre-invex F-N∙V∙Ms). With the help of this newly defined class, some new versions of Hermite–Hadamard (HH) type inequalities have been also presented. Moreover, some related inequalities such as HH Fejér- and Pachpatte-type inequalities for U∙D h-pre-invex F-N∙V∙Ms are also introduced. Some exceptional cases have been discussed, which can be seen as applications of the main results. We have provided some nontrivial examples. Finally, we also discuss some future scopes.
Análisis de los parámetros fisicoquímicos de la perforación del pozo exploratorio Chocol-1 ubicado entre la ciudad de Comalcalco-Paraíso para la identificación de un posible yacimiento
Authors: Méndez-González José del Carmen , Villareal-Ibarra Edelia Claudina 
Published: December 2022

La búsqueda de hidrocarburos ha obligado a perforar a mayores profundidades, esto exige a la industria petrolera retos cada vez mayores y difíciles de vencer, la presente investigación se llevó a cabo con datos proporcionados del pozo exploratorio Chocol-1 ubicado a 8 km al sur de la ciudad de Paraíso, así como a 10 km al norte de la ciudad de Comalcalco.
Para la perforación del pozo Chocol-1 se hizo uso de la correlación, la cual se ha considerado como una de las técnicas más aplicables en la industria petrolera, donde se obtienen datos de primera instancia mediante la comparación de ciertos parámetros, para ello se tomaron datos de los pozos Pareto-1, Arrastradero-201 y Aarrastradero-301. El uso de la metodología de correlación proporciona datos veraces que permiten extrapolar a trabajo de campo, con un ahorro significativo en herramientas, equipos, personal, y además una disminución en el número de pozos exploratorios, ayudando con esto a minimizar costos en diversos conceptos.
ANALISIS USAHA INDUSTRI TEMPE KEDELAI DI DESA KACANGAN KECAMATAN NGUNUT KABUPATEN TULUNGAGUNG
Authors: Herry Nur Faisal Herry Nur Faisal , Hajar Prasekti Yuniar 
Published: December 2022

Tempe merupakan sumber protein dan serat yang sangat bermanfaat bagi tubuh kita. Meskipun tergolong sebagai bahan pangan tradisional, tempe masih banyak digemari oleh masyarakat kita. Terutama bagi vegetarian yang membutuhkan protein nabati sebagai pengganti protein hewani. Dalam proses pembuatan tempe yang dijalankan dengan menganalisis struktur biaya yang dilakukan serta menganalisis penerimaan dan pendapatan usaha pembuatan tempe. Adapun pembuatan tempe adalah pemilihan biji, kedelai, dibersihkan dari kotoran, pencucian, perebusan, perendaman.
Dari hasil penelitian pendapatan usaha pembuatan tempe di Desa Kacangan setiap responden dapat diketahui dari selisih penerimaan dengan biaya-biaya yang telah dikeluarkan. Besarnya pendapatan yang diperoleh pengusaha tempe di Desa Kacangan pada bulan April 2022 Rp 57.647.000. Dengan rata-rata setiap responden adalah Rp 19.215.666. Total biaya yang dikeluarkan pada pembuatan tempe adalah sebesar Rp 3.360.000/hr. Proporsi terbesar dikeluarkan untuk penyediaan bahan-bahan yang mencapai 82,75%. Biaya tenaga kerja yang digunakan adalah tenaga kerja dalam keluarga. Pada analisis ini biaya tenaga kerja dalam keluarga ikut di perhitungkan sebagai komponen biaya produksi.
Hasil perhitungan terhadap penerimaan dari usaha tempe dapat diketahui rata-rata tempe yang dihasilkan setiap hari Rp 1.120.000.Pendapatan bersih usaha ini adalah selisih antara pendapatan kotornya (penerimaan) dengan pengeluaran total yang digunakan untuk usahanya (usaha tempe). Sehingga pendapatan usahanya adalah selisih antara penerimaan semua biaya dengan formulasi sebagai berikut :Jika dihitung dengan tingkat efisiensi, maka dapat diketahui melalui perbandingan antara besarnya penerimaan dengan biaya yang di kenal dengan R/C ratio.
Dari perhitungan R/C ratio di dapatkan bahwa R/C ratio produksi tempe di Desa Kacangan menghasilkan R/C ratio di atas 1 ini berarti usaha produksi tempe di Desa Kacangan yang dilakukan sampel adalah efisien dan menguntungkan sehingga disimpulkan layak secara ekonomi layak untuk di kembangkan. Rasio tersebut berarti bahwa setiap penambahan satu-satuan biaya produksi akan memberikan peningkatan penerimaan sebesar 2,33%.
Uji Lama Simpan Benih Kedelai Varietas Dering dan Argomulyo terhadap Mutu Fisiologi Benih
Authors: Endrawati Tri , Kurnia Ardi Angelita 
Published: December 2022

Budidaya tanaman kedelai mempunyai beberpa hambatan salah satu factor hambatan yaitu adanya kemunduran benih akibat lamanya penyimpanan. Untuk mengatasi adanya kemunduran benih perlunya suatu penelitian yang mengetahui lama simpan varietas kedelai terhadap mutu fiologi benih sehingga dapat diketahui pada lama simpan berapa benih masih tetap dapat digunakan. Penelitian bertujuan untuk mengetahui mutu fisiologi benih kedelai varietas Dering dan Argomulyo terhadap lama simpan serta untuk mendapatkan perlakuan terbaik mutu fisiologi benih kedelai varietas Dering dan Argomulyo terhadap lama simpan. Penelitian akan dilaksanakan di Desa Rejowinangun Kecamatan Kademangan Kabupaten Blitar Mei 2022 – Agustus 2022. Penelitian menggunakan Rancangan Rancangan Acak Kelompok (RAK) split plot, dimana perlakuan yaitu varietas Dering (VD) dan varietas Argomulyo (VA), dengan penyimpanan 1, 2 dan 3 bulan. tiap perlakuan dikali 3 diulang 3 kali sehingga terdapat 18 unit perlakuan, yaitu sebagai berikut : VD : Benih varietas Dering, VA : Benih varietas Argomulyo. Data yang telah di peroleh akan dianalisis dengan analisis ragam. Uji Jarak Berganda Duncan (UJBD) diikuti pada tingkat kepercayaan 95% jika analisis memiliki dampak nyata. Hasil penelitian dapat disimpulkan bahwa perlakuan lama simpan 1 bulan dengan varietas argomulyo memiliki mutu fisiologi meliputi daya kecambah, indeks vigor serta kecepatan tumbuh yang paling baik dan rata-rata menurunya mutu fisiologi terdapat pada lama penyimpanan 3 bulan dengan varietas dering.
Strategi Peningkatan Pelayanan Air Minum Di Kelurahan Buntusu Kota Makassar
Authors: Risno Dandi , Azis Fuad , Arief Rimba 
Published: December 2022

Abstract. The purpose of this study was to determine community satisfaction with water services in Buntusu Village, namely with water services and water quantity which had a significant effect so that community satisfaction with water services was tested using qualitative descriptive analysis tools and quantitative descriptive analysis using linear regression method. Factors that have a direct and significant effect on community satisfaction from the results of linear regression analysis, there are 2 stimulants of drinking water services (X1), and the quantity of drinking water (X3) the results are accepted meaning that it does not significantly affect community satisfaction. While the factors that do not have a direct significant effect on community satisfaction from the results of linear regression analysis, there are two, namely stimulants of drinking water quality (X2) and drinking water continuity (X4), then the results are rejected, meaning that they have a significant effect on community satisfaction.

Abstrak. Tujuan dari penelitian ini adalah untuk mengetahui kepuasan masyarakat terhadap pelayanan air di Kelurahan Buntusu yaitu dengan pelayanan air dan kuantitas air yang berpengaruh secara signifikan sehingga kepuasan masyarakat terhadap pelayanan air diuji menggunakan alat analisis deskriptif kualitatif dan deskriptif kuantitatif dengan mnggunakan metode regresi Linier Faktor yang berpengaruh secara langsung secara signifikan terhadap kepuasan masyarakat dari hasil analisis Regresi linier maka ada 2 stimulan pelayanan air minum (X1), dan kuantitas air minum (X3) hasilnya di terima artinya tidak berpengaruh secara signifikan terhadap kepuasan masyarakat. Sedangkan Faktor yang tidak berpengaruh signifikan secara langsung terhadap kepuasan masyarakat dari hasil analisis Regresi linier maka ada dua yaitu stimulan kualitas air minum (X2) dan kontinuitas air minum (X4), maka hasilnya di tolak artinya berpengaruh secara signifikan terhadap kepuasan masyarakat.