bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon offsetting and renewable energy development
Authors: Lo Alex Y. 
Published: May 2023

AbstractNew carbon crediting and offsetting mechanisms are being developed under the Paris Agreement. Polluters can meet their emission reduction targets by acquiring and retiring carbon offset credits. Globally, most of these credits come from renewable energy sources. However, their additionality is increasingly questionable. Global renewable electricity capacity continues to grow. Greenhouse gas emissions from coal‐fired power generation are starting to fall, as governments and organisations pledge to curtail emissions, more capital is mobilised for energy transition, and renewable energy technologies become commercially competitive. The opportunity to earn carbon offset credits is becoming less indispensable to renewable energy development. Aggregate emissions could rise above the baseline level when polluters increase their emission budgets by using carbon credits generated from a renewable energy installation that is part of the baseline scenario. To safeguard environmental integrity, the conditions for including renewable energy in carbon crediting and offsetting schemes should be reconsidered.
Interaction between major catechins and umami amino acids in green tea based on electronic tongue technology
Authors: Liu Zhongying , Ran Qiansong , Li Qin , Yang Ting , Dai Yuqiao , Zhang Tuo , Fang Shimao , Pan Ke , Long Lin 
Published: May 2023

AbstractUmami amino acids inhibit the bitter and astringent taste presentation of catechins, which is essential for the taste regulation of green tea. In this study, the concentration–intensity trends and taste threshold properties of major catechin monomers were investigated using an electronic tongue. The taste and chemical structure interactions between the ester‐type catechins and theanine, glutamic acid (Glu), and aspartic acid (Asp) were further analyzed by in vitro simulation and analysis of their reciprocal chemical structures. The results showed that the bitterness and astringency of the major catechin monomers increased with increasing concentration, and their bitterness thresholds and their electron tongue response values were higher than those of the astringent values, while the bitterness and astringency of the ester‐type catechins were higher than those of the nonester type. The three amino acids inhibited the bitterness intensity of ester catechins (epigallocatechin gallate, epicatechin gallate, and gallocatechin gallate) at different concentrations, and the effects on the astringency intensity of ester catechins were complicated. Ester catechins significantly enhanced the umami intensity of theanine, Glu, and Asp at different concentrations. Their reciprocal chemical structures showed that hydrogen bonding was the main interaction force between the three ester‐type catechins and the umami amino acids, with theanine and Glu interacting more strongly with ester‐type catechins than Asp, and Glu having a lower binding energy to ester‐type catechins, which bonded more easily.
Comparison between the WHO‐CFICPS and the PRISMA classification of safety‐related events in a radiation oncology department
Authors: Ben Mustapha Selma , Cucchiaro Séverine , Goreux Joelle , Delgaudine Marie , Boga Deniz , Donneau Anne‐Françoise , Diep Anh Nguyet , Coucke Philippe 
Published: May 2023

AbstractIntroductionDescribing Safety‐Related Events (SREs) in a radiotherapy (RT) department and comparing WHO‐CFICPS (World Health Organization's Conceptual Framework For The International Classification For Patient Safety) and PRISMA (Prevention and Recovery Information System for Monitoring and Analysis) methods for classifying SREs.MethodsFrom February 2017 to October 2020, two Quality Managers (QMs) randomly classified 1173 SREs using 13 incident types of WHO‐CFICPS. The same two QMs, reclassified the same SREs according to 20 PRISMA incident codes. Statistical analysis was performed to assess the association between the 13 incident types of WHO‐CFICPS and the 20 PRISMA codes. The chi‐squared and post‐hoc tests using adjusted standardized residuals were applied to detect the association between the two systems.ResultsThere was a significant association between WHO‐CFICPS incident types and PRISMA codes (P < 0.001). Ninety‐two percent of all SREs were categorized using 4 of 13 WHO‐CFICPS incident types including Clinical Process/Procedure (n = 448, 38.2%), Clinical Administration (n = 248, 21.1%), Documentation (n = 226, 19.2%) and Resources/Organizational Management (n = 15,613.3%). According to PRISMA classification, 14 of the 20 codes were used to describe the same SREs. PRISMA captured 41 Humans Skill Slips from 226 not better defined WHO‐CFICPS Documentation Incidents, 38 Human Rule‐based behaviour Qualification from not better defined 447 Clinical Process/Procedure and 40 Organization Management priority events from 156 not better defined WHO‐CFICPS Resources/Organizational Management events (P < 0.001).ConclusionAlthough there was a significant association between WHO‐CFICPS and PRISMA, The PRISMA method provides a more detailed insight into SREs compared to WHO‐CFICPS in a RT department.
Topical negative pressure wound therapy to prevent wound complications following caesarean delivery in high‐risk obstetric patients: A randomised controlled trial
Authors: Gonzalez Maritza G. , Barske M. Elisa , Kjellsson Kristine B. , Saboda Kathylynn , Reed Heather A. , Hill Meghan G. 
Published: May 2023

Background and AimsWe investigated whether the use of a prophylactic negative pressure wound therapy (NPWT) system in women undergoing caesarean would decrease wound complications in a high‐risk population.Materials and MethodsA randomised controlled trial was performed. Women with risk factors for wound complications undergoing caesarean delivery were randomised to a standard dressing or NPWT placed over their caesarean wound. We standardised the closure of the subcutaneous fat and skin layers, both with Vicryl. Patients were followed for wound complications for up to 6 weeks after their caesareans. The incidence of wound complications was the primary outcome. The single‐use NPWT system, PICO, was provided by Smith and Nephew for use in this trial. The trial was registered on clinicaltrials.gov, # NCT03082664.ResultsWe report here on 154 women randomised to either a standard dressing or to the NPWT. Wound complication rates were equivalent between groups, with 19.4 and 19.7% (P = 0.43) of women with follow‐up information available experiencing wound complications.ConclusionWe found no difference in wound complications in women with risk factors treated with a prophylactic NPWT system or standard wound dressing at the time of caesarean birth.
Detection of multiple druggable mutations of lung cancer from cytology specimens by MINtS: An advanced medicine A trial
Authors: Fujita Kazutaka , Arai Ryo , Shoji Satoshi , Saito Ryota , Nomura Motoko , Hotta Takamasa , Asahina Hajime , Kawakami Masanori , Nakachi Ichiro , Hasegawa Yukihiro , Okafuji Kohei , Suzuki Aya , Miyanaga Akihiko , Sunaga Noriaki , Nagashima Hiromi , Ikeda Naoya , Watanabe Satoshi , Nagai Yoshiaki , Furuta Megumi , Kage Hidenori , Arai Daisuke , Fukuhara Tatsuro , Nakayama Masayuki , Morita Satoshi , Kobayashi Kunihiko , Hagiwara Koichi 
Published: May 2023

AbstractMost multigene mutation tests require tissue specimens. However, cytological specimens are easily obtained in the clinical practice and provide high‐quality DNA and RNA. We aimed to establish a test that utilizes cytological specimens and performed a multi‐institutional study to investigate the performance of MINtS, a test based on next‐generation sequencing. A standard procedure for specimen isolation was defined. The specimens were considered suitable for the test if >100 ng DNA and >50 ng RNA could be extracted from them. In total, 500 specimens from 19 institutions were investigated. MINtS detected druggable mutations in 63% (136 of 222) of adenocarcinomas. Discordant results between MINtS and the companion diagnostics were observed in 14 of 310 specimens for the EGFR gene, and 6 of 339 specimens for the ALK fusion genes. Confirmation by other companion diagnostics for the EGFR mutations or the clinical response to an ALK inhibitor all supported the results obtained by MINtS. MINtS along with the isolation procedure presented in the current study will be a platform to establish multigene mutation tests that utilize cytological specimens. UMIN000040415.
Think of the children!: Relationships between nudity‐related experiences in childhood, body image, self‐esteem and adjustment
Authors: West Keon 
Published: May 2023

AbstractThere are widespread, strongly held beliefs that naturism has a negative impact on children. However, naturist groups advocate for including children and prior research has not clearly investigated how naturism affects children. Two pre‐registered, cross‐sectional studies (N1 = 411, N2 = 250) investigated how nudity‐related experiences in childhood predicted overall adjustment. In Study 1, adults reported their recalled experiences of nudity in childhood as well as their current levels of body appreciation, self‐esteem and overall adjustment. In Study 2, mothers reported on their children's current experiences of nudity and the children themselves reported on their current levels of body appreciation, self‐esteem and overall adjustment. Results for both studies were similar (though in Study 2, some associations only approached statistical significance): Experiences of naturism were associated with positive, not negative outcomes. These findings suggest that, despite the concerns some people express, naturism does not generally lead to negative outcomes for children.
Non‐surgical treatment of mild to moderate peri‐implantitis with an oscillating chitosan brush or a titanium curette—12‐month follow‐up of a multicenter randomized clinical trial
Authors: Khan Sadia N. , Koldsland Odd Carsten , Roos‐Jansåker Ann‐Marie , Wohlfahrt Johan Caspar , Verket Anders , Mdala Ibrahimu , Magnusson Anna , Salvesen Eirik , Hjortsjö Carl 
Published: May 2023

AbstractObjectivesTo study clinical and radiographic outcomes after non‐surgical treatment of peri‐implantitis using either an oscillating chitosan brush (OCB) or titanium curette (TC) and to observe changes in clinical signs of inflammation after repeated treatment.MethodsThirty‐nine patients with dental implants (n = 39) presented with radiographic bone level (RBL) of 2–4 mm, bleeding index (BI) ≥ 2, and probing pocket depth (PPD) ≥ 4 mm were randomly assigned to mechanical debridement with OCB (test) or TC (control). Treatment was performed at baseline and repeated at 3, 6, and 9 months in cases with > 1 implant site with BI ≥ 1 and PPD≥4 mm. Blinded examiners recorded PPD, BI, pus, and plaque. The radiographic bone level change between baseline and 12 months was calculated. A multistate model was used to calculate transitions of BI.ResultsThirty‐one patients completed the study. Both groups exhibited a significant reduction in PPD, BI, and pus at 12 months compared to baseline. Radiographic analysis showed stable mean RBL in both groups at 12 months. There was no statistically significant difference in any of the parameters between the groups.ConclusionsWithin the limitations of this 12‐month multicenter randomized clinical trial, non‐surgical treatment of peri‐implantitis with OCB or TC showed no statistically significant differences between the groups. Clinical improvements and, in some cases, disease resolution, was observed in both groups. However, persistent inflammation was a common finding which further puts emphasis on the need for further treatment.
Prenatal ultrasound findings, genetic testing, and literature review of Isolated left subclavian artery
Authors: Zhang Simin , Wang Jingjing , Han Jijing , Wang Li , Wang Limei , Xiong Xiaowei , Wu Qingqing 
Published: May 2023

AbstractBackgroundThe occurrence of Isolated left subclavian artery (ILSA) is relatively rare, ILSA is caused by the persistence of the dorsal segment of the sixth left arch, with regression of the fourth arch artery and interruption of the left dorsal aorta at the distal end of the seventh intersegmental artery on the left side during embryonic development. The left subclavian artery is connected to the pulmonary artery through an arterial duct, which can be closed or unobstructed. This abnormality can lead to congenital subclavian steal syndrome and vertebrobasilar artery insufficiency.Case presentationWe reported three fetuses with ILSA and intracardiac malformation. Among them, one case was suspected to be diagnosed with ILSA by echocardiography, while the other two cases were not diagnosed, but were accidentally discovered during autopsy. We have also conducted a literature review of its prenatal screening, diagnosis, management, and outcomes. Our three cases were tested by WES‐Trio (whole exome sequencing). Worldwide, the ILSA cases reported in English literature have not been detected by WES. And likely pathogenic results were found in our two cases. Although it could not explain the intracardiac malformation we found, it will help to explore the etiology in the future.ConclusionsPrenatal echocardiography detection and diagnosis of ILSA is a new challenge, which has different effects on the prognosis of the fetus. When finding intracardiac malformation with right aortic arch, we need to perform an unconventional view of ultrasound scanning and combine with CDFI to find the origin of the left subclavian artery. Although we cannot find the cause of the disease temporarily, but our genetic results can help prenatal genetic counseling.
Impact of sodium‐glucose cotransporter‐2 inhibitors on the risk of hip fracture in older patients in Japan using a nationwide administrative claims database: A matched case–control study
Authors: Saito Tomoyuki , Nojiri Shuko , Kasai Takatoshi , Hiratsuka Yoshimune , Ishijima Muneaki , Daida Hiroyuki 
Published: May 2023

AimSome clinical trials have shown that sodium‐glucose cotransporter‐2 (SGLT2) inhibitors are associated with fracture risk. However, this notion remains controversial. This study aimed to evaluate hip fracture risk after the use of SGLT2 inhibitors while controlling for factors that may affect fracture risk. Furthermore, hip fracture risk is evaluated in relation to the SGLT2 inhibitors component and its concomitant use with other antidiabetic agents.MethodsUsing large‐scale real‐world data, this case–control study investigated hospitalized patients between January 2018 and December 2020. Patients were aged 65–89 years and had been prescribed with SGLT2 inhibitors at least twice. Patients with hip fracture (cases) and those without (controls) were identified via 1:3 matching according to sex, age (±3 years), hospital size classification, and number of concomitant antidiabetic agents. Exposure to SGLT2 inhibitors of the cases and controls was compared with the use of multivariate conditional logistic regression.ResultsAfter matching, 396 cases and 1081 controls were identified. The adjusted odds ratio for patients receiving treatment with SGLT2 inhibitors was 0.83 (95% confidence interval: 0.55–1.26), indicating no increase in hip fracture risk. Additionally, no increased risk was observed with respect to SGLT2 inhibitors by component or concomitant use with other antidiabetic agents.ConclusionOur study showed that SGLT2 inhibitors do not increase hip fractures in older patients. However, because the risk assessment of SGLT2 inhibitors by component and their concomitant use with other antidiabetic agents is based on a limited number of patients, it is important to interpret the results with caution. Geriatr Gerontol Int 2023; 23: 418–425.
Induction of MMP‐3 and MMP‐9 expression during Helicobacter pylori infection via MAPK signaling pathways
Authors: Karayiannis Ioannis , Martinez‐Gonzalez Beatriz , Kontizas Eleftherios , Kokkota Androniki Voulgari , Petraki Kalliopi , Mentis Andreas , Kollia Panagoula , Sgouras Dionyssios Nicholas 
Published: May 2023

AbstractBackground and AimsHelicobacter pylori (H. pylori)‐induced gastric pathology involves remodeling of extracellular matrix mediated by aberrant activity of matrix metalloproteinases (MMPs). We have previously shown that in vitro H. pylori infection leads to MMP‐3 and MMP‐9 overexpression, associated with phosphorylation of bacterial oncoprotein CagA. We extended these findings in an in vivo model of H. pylori infection and further assessed the involvement of MAPK pathways in MMP expression.Materials and MethodsC57BL/6 mice were infected with H. pylori strains HPARE, HPARE ΔCagA, and SS1, for 6 and 9 months. Transcriptional expression of Mmp‐3 and Mmp‐9 was evaluated via qPCR while respective protein levels in the gastric mucosa were determined immunohistochemically. Epithelial cell lines AGS and GES‐1 were infected with H. pylori strain P12 in the presence of chemical inhibitors of JNK, ERK1/2, and p38 pathways, for 24 h. mRNA and protein expression of MMP‐3 and MMP‐9 were determined via qPCR and Western blot, respectively.ResultsWe observed transcriptional activation of Mmp‐3 and Mmp‐9 as well as aberrant MMP‐3 and MMP‐9 protein expression in murine gastric tissue following H. pylori infection. CagA expression was associated with MMP upregulation, particularly during the early time points of infection. We found that inhibition of ERK1/2 resulted in reduced mRNA and protein expression of MMP‐3 and MMP‐9 during H. pylori infection, in both cell lines. Expressed protein levels of both MMPs were also found reduced in the presence of JNK pathway inhibitors in both cell lines. However, p38 inhibition resulted in a more complex effect, probably attributed to the accumulation of phospho‐p38 and increased phospho‐ERK1/2 activity due to crosstalk between MAPK pathways.ConclusionsH. pylori colonization leads to the upregulation of MMP‐3 and MMP‐9 in vivo, which primarily involves ERK1/2 and JNK pathways. Therefore, their inhibition may potentially offer a protective effect against gastric carcinogenesis and metastasis.
Engagement in collaborative writing: Exploring learners’ control of task content and text quality
Authors: Phan Huong Le Thu , Dao Phung 
Published: May 2023

AbstractTo extend L2 collaborative writing (CW) research that has largely focused on learners’ interactional behaviours and written performance, the current study adopted learner engagement as a theoretical lens to investigate whether different aspects of learner engagement in CW (i.e., cognitive, emotional and social) are affected by learners’ control of task content and whether they predict text quality. Thirty ESL learners performed two CW tasks, with the first task giving learners all pictures to co‐construct a story in writing whereas in the second task they were given half of the picture set and thus had to self‐produce the content for the rest of the story. Learner engagement during CW was gauged by multiple measures (e.g., LREs, idea units, instances of responsiveness, and self‐rated emotions). Post‐task interviews were conducted to supplement the quantitative results about the impact of the control of task content on learner engagement. Discourse analysis was applied to examine the linguistic aspects of the joint‐written text. Learner engagement scores were compared across two task conditions and entered into regression models to examine their association with the text quality. Results revealed that learners showed and reported higher cognitive, social, and emotional engagement in CW when they had greater control over the task content than when provided with all content. LREs, an indicator of cognitive engagement, were found to predict the texts’ accuracy. Results are discussed in terms of the design of CW tasks and the role of learner engagement in text quality.
Migration aspirations and the perceptions of the political, economic and social environment in Africa
Authors: Helbling Marc , Morgenstern Sandra 
Published: May 2023

AbstractWhile much research has investigated how objective pull factors in the destination countries affect migration movements, and how subjective push factors affect migration aspirations, we know little about the interrelationship between subjective and objective factors. This paper therefore examines how people's perceptions of their political, economic and social structural environment affect their migration aspirations and to what extent these perceptions are determined by the objective situation in a country. Accounting for individual perceptions is important because individuals may be affected by structural factors to different degrees, and their knowledge of the objective situation may vary. Perceptions may also be affected by individuals' norms and values as well as people's different expectations. This study is based on data from Round 7 of the Afrobarometer survey, fielded between 2016 and 2018 in 34 African countries. Our findings show that positive perceptions of the structural environment are related to lower migration aspirations and that this relationship is only partly dependent on the objective situation in a country.
Clinical performance characteristics for bordered foam dressings in the treatment of complex wounds: An international wound dressing technology expert panel review
Authors: Santamaria Nick , Woo Kevin , Beeckman Dimitri , Alves Paulo , Cullen Breda , Gefen Amit , Lázaro‐Martínez José Luis , Lev‐Tov Hadar , Najafi Bijan , Sharpe Andrew , Swanson Terry 
Published: May 2023

AbstractThe aim of this article is to identify and describe clinical practice performance characteristics for bordered foam dressings in the treatment of complex wounds. Our recently published systematic review of outcomes and applied measurement instruments for the use of bordered foam dressings in complex wounds has led to us identifying a range of important clinical and patient‐centred issues related to this dressing class. Specifically, here, we focus on an overview of performance criteria in the areas of application, adhesion, exudate management and debridement functions of bordered foam dressings. Our hope is that by highlighting the clinical performance criteria, future testing standards for wound dressings will more closely match our clinical expectations and, thereby, assist clinicians to make better wound treatment choices based on meaningful and clinically relevant dressing product performance standards. complex wounds, complex wound care, treatment, bordered foam dressings, dressing performance.
Plant photosynthetic responses under drought stress: Effects and management
Authors: Zahra Noreen , Hafeez Muhammad Bilal , Kausar Abida , Al Zeidi Maryam , Asekova Sovetgul , Siddique Kadambot H. M. , Farooq Muhammad 
Published: May 2023

AbstractBalanced photosynthesis is essential for improved plant survival and agricultural benefits in terms of biomass and yield. Photosynthesis is the hub of energy metabolism in plants; however, drought stress (DS) strongly perturbs photosynthetic efficiency due to biochemical and diffusive limitations that reduce key photosynthetic components and close stomata. This review describes photosynthetic responses, chloroplast retrograde signalling, and genetic imprints that curtail DS damage to photosynthetic machinery. While stomatal closure, disrupted photosynthetic systems, over‐reduced electron transport rates (ETR), partial hindrance of the Calvin cycle, and reduced pigment contents strongly affect the repertoire of photosynthetic processes under DS, chloroplast retrograde signalling also has a plausible role in preserving photosynthetic capacity. Progress in agronomic, genetic engineering approaches and isoprene regulation would help to rescue photosynthetic apparatus under DS.