bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-exome sequencing applications in prenatal diagnosis of fetal bowel dilatation
Authors: Bian Xinyi , Yang Xiao , Shi Xinwei , Zeng Wanjiang , Deng Dongrui , Chen Suhua , Qiao Fuyuan , Feng Ling , Wu Yuanyuan 
Published: May 2023

Abstract
This study introduced whole-exome sequencing (WES) in prenatal diagnosis of fetal bowel dilatation to improve the detection outcome when karyotype analysis and copy number variation sequencing (CNV-seq) were uninformative in detecting pathogenic variants. The work reviewed 28 cases diagnosed with fetal bowel dilatation and analyzed the results of karyotype analysis, CNV-seq, and WES. Among the 28 cases, the detection rate in cases with low risk of aneuploidy was 11.54% (3/26), which is lower than 100% (2/2) in cases with high risk of aneuploidy. Ten low-risk aneuploidy cases with isolated fetal bowel dilatation had normal genetic testing results, while the remaining 16 cases with other ultrasound abnormalities were detected for genetic variants at a rate of 18.75% (3/16). The detection rate of gene variation was 3.85% (1/26) by CNV-seq and 7.69% (2/26) by WES. This study suggested that WES could reveal more genetic risk in prenatal diagnosis of fetal bowel dilatation and has value in prenatal diagnosis to reduce birth defects.
Pharmacogenetic predictors of development of secondary to enalapril dry cough in hypertensive patients
Authors: Sychev Ivan V. , Denisenko Natalia P. , Kachanova Anastasiya A. , Lapshtaeva Anna V. , Goncharova Ludmila N. , Mirzaev Karin B. , Sychev Dmitry A. 
Published: May 2023

Abstract

Objectives
Development of the secondary to ACEI cough leads to discontinuation of the drugs of this group. Assessing the safety of the ACEIs with further development of customized approaches for their administration is a major scientific and practical problem. The objective of this study was to assess the association of the genetic markers with the development of the adverse drug reaction in the form of secondary to enalapril dry cough in the patients with essential arterial hypertension.

Methods
Study involved 113 patients with the secondary to enalapril cough and 104 patients without development of the secondary to enalapril adverse drug reaction.

Results
The patients carriers of the genotype AA rs2306283 of gene SLCO1B1 had 2-fold higher odds of developing the dry cough than those with the genotypes AG and GG (ОR=2.01, 95%CI=1.10–3.66, р=0.023). Similarly, the patients heterozygous for rs8176746 of gene АВО had 2.3-fold higher odds of developing the ADR in the form of dry cough than the carriers of the genotypes GG and TT (ОR=2.30, 95%CI=1.24–4.29, р=0.008).

Conclusions
Statistically significant association between the development of the ADR in the form of secondary to enalapril dry cough and polymorphisms rs2306283 of gene SLCO1B1 and rs8176746 of gene ABO was revealed.
From Conformity to Sustainability: Understanding the Implications of Digital Content Modifications under Directives 2019/770 and 771
Authors: Barceló Compte Rosa 
Published: May 2023

Abstract
Directive 2019/770, of 20 May, on certain aspects concerning contracts for the supply of digital content and digital services addresses the possibility for the trader to modify features of the digital content or digital service supplied or made accessible to the consumer over a period of time. Considering the fast-evolving character of digital elements, modifications can be advantageous for the consumer. Such modifications can be divided into two categories: those necessary to maintain the conformity of the digital content or service (the updates referred to in the Directive) and those that are unnecessary or evolutionary, which would deviate from the objective requirements for conformity and which are foreseeable at the time of conclusion of the contract. The modifications that are necessary to keep conformity with the contract are also foreseen in the Sale of Goods Directive (Directive 2019/771), given that the digital content or digital service incorporated in or interconnected with the goods is constantly developing. However, this directive dos not make any provision for unnecessary or evolutionary modifications. The main purpose of this article is to examine the category of non-necessary modifications referred to exclusively in the Directive 2019/770. It also analyses the possibility of modifying the digital element that accompanies the good (in categories of good with digital elements). The analysis is approached from the perspective of unfair commercial practices and the need to address the premature wear and tear of the so-called goods with digital elements.
Faculty experiences of teaching internationally educated nurses: a qualitative study
Authors: Crockford Gail N. , Pesut Barbara , Plamondon Katrina , Janzen Randy 
Published: May 2023

Abstract

Objectives
The aim of this study was to explore the experiences of faculty teaching in programs designed to support internationally educated nurses’ transition to nursing practice in Canada.

Methods
This was a qualitative study that gathered data through semi-structured interviews.

Results
Four themes were developed from the data: learning the learner, feeling moral unrest in my role, inviting reciprocal relationships, and finding our way.

Conclusions
There is an urgent need to ensure that faculty are well prepared for their role and that the needs of internationally educated nurses, both personal and pedagogical, are central. Despite the challenges experienced by faculty, they also describe great growth as a result of their new role.

Implications for an International Audience
Findings from this study are particularly relevant for those in high income countries seeking to support internationally educated nurses. Faculty preparedness and holistic support for students are critical for ethical, high-quality education.
Logic Validity E-Module Behavior Counseling Practicum Based on Case Study to Improve Critical Thinking of Guidance and Counseling Students
Authors: Indreswari Henny , Fauzan Lutfi , Probowati Devi , Apriani Rizka 
Published: May 2023

Abstract: One of the courses that must be taken as a graduation requirement for Guidance and Counseling students at the Faculty of Education, Universitas Negeri Malang is behavior counseling practicum. This study aimed to develop a logically validated case study based on counseling behavior e-module so that it can be applied to guidance and counseling students at Universitas Negeri Malang. The research and development design used in this study is the ADDIE model. The data in this study are divided into quantitative and qualitative data based on the acceptability aspect of the e-module. The subjects in this study were counseling experts, media, language, and prospective users. The product test results from the counseling expert validator have a validity index of 1 in the category "very high" media experts show a validity of 0.93 "very high"; linguists score 0.90 in the category "very high", and potential users category 3.55. So it is determined that the product being developed meets the product acceptance criteria from various predetermined aspects.
Abstrak: Salah satu matakuliah yang wajib ditempuh sebagai syarat kelulusan mahasiswa bimbingan dan konseling fakultas ilmu pendidikan Universitas Negeri Malang adalah praktikum konseling berhavior. Tujuan penelitian ini adalah untuk mengembangkan e-modul konseling behavior berbasis case study yang tervalidasi secara logik sehingga dapat diterapkan kepada mahasiswa bimbingan dan konseling Universitas Negeri Malang. Rancangan penelitian dan pengembangan yang digunakan dalam penelitian ini adalah model ADDIE. Data dalam penelitian ini dibedakan menjadi data kuantitatif dan kualitatif berdasarkan aspek keberterimaan e-modul. Subjek dalam penelitian ini yaitu ahli bimbingan dan konseling, media, bahasa, dan calon pengguna. Hasil uji produk dari validator ahli bimbingan dan konseling memiliki indeks validitas 1 kategori “sangat tinggi”, ahli media menunjukkan validitas 0,93 “sangat tinggi”, ahli bahasa sebesar 0,90 kategori “sangat tinggi”, dan calon pengguna kategori 3,55. Sehingga disimpulkan bahwa produk yang dikembangkan telah memenuhi kriteria keberterimaan produk dari berbagai aspek yang telah ditentukan.
Is mifepristone a game changer in induction of labour..?
Authors: Vellanki Janaki , Harmain Zaara , Limmala Rani Kumari 
Published: May 2023

: Induction of labor is defined as artificially stimulating the uterus to start labor. Mifepristone is a synthetic steroid hormone analog that has both anti-progesterone and anti-glucocorticoid activities. This study aimed to study the efficacy of mifepristone in the induction of labor and cervical ripening.: This study was conducted in Gandhi Hospital from August 2022 to November 2022. A total of 100 antenatal cases were admitted for safe confinement after 37 completed weeks and given oral mifepristone 200 mg and assessed for cervical ripening and need for further augmentation and the outcome was studied based on improvement in bishops score assessed after 24 hours of intake of oral mifepristone. It was observed that there was a significant improvement in the bishop’s score 24 hours after giving mifepristone. Out of 100 women who were given mifepristone, 79% delivered vaginally and 21% delivered through emergency cesarean section. The major indication for emergency cesarean section was fetal distress. The majority of patients had good neonatal outcomes and there were no serious maternal complications. Mifepristone is an effective and safe method of induction of labor with significant improvement in Bishop's score within 24 hours of administration.
Role of prophylactic use of tranexamic acid in reducing blood loss during caesarean section in a tertiary care hospital
Authors: Gopalan Ushadevi , Mathumitha K 
Published: May 2023

Postpartum Haemorrhage (PPH) is an important cause of maternal death and severe maternal morbidity. Compared to vaginal delivery, women undergoing caesarean delivery incur the highest risk of PPH and haemorrhage related morbidity. Furthermore, evidence suggests that PPH during caesarean delivery is occurring more frequently. To study the effect of low dose intravenous tranexamic acid in reducing blood loss during Caesarean section.: This randomized control trial among 50 antenatal women aged &#62;18 years undergoing Lower segment caesarean section in tertiary care centre. They were divided into Study group and control group. Study group received 1gm iv tranexamic acid and the Control group did not receive tranexamic acid. Data was entered in Microsoft Excel data sheet (MS-Excel) and analysed using commercially available SPSS 23 software package. MS Excel and MS word was used to obtain various types of graphs such as bar diagram. : Among the study population who underwent Lower section caesarean section in our study, we found that the requirement of additional oxytocin was nil with tranexamic acid group (p value&#60;0.02). There were no side effects observed with the group administered tranexamic acid (p value&#60;0.01). The difference in mean of bleeding from placental delivery to end of Caesarean Section, End of Caesarean Section to 2 hrs Postpartum was statistically significant (p value &#60;0.05). The fall in Hb% between the two groups was significant, thereby showing the benefits of Tranexamic acid.: Tranexamic acid significantly reduces the amount of blood loss during and after lower segment caesarean section. It was not associated with any significant side effects and complications. It can be used effectively in all women undergoing caesarean section to reduce the postpartum Haemorrhage thereby reducing the maternal morbidity and mortality.
Efficacy of tablet metronidazole and clindamycin in management of bacterial vaginosis in a tertiary care hospital in Chengalpattu district
Authors: Kondapalli Saraswathi 
Published: May 2023

BV is a common disorder, yet poorly understood poly-microbial vaginal infection. It is more commonly seen in women in reproductive age group. It has high prevalence in African women specially those in sub-Saharan Africa. Approximately 50-69% of women with BV are not symptomatic and women who presents with symptoms varies from Gray-white offensive vaginal discharge intensified after sexual intercourse and during menstruation, lower abdominal pain and dyspareunia. BV is diagnosed by two different criteria such as Amsel’s and Nugent’s. After the diagnosis according to the above criteria, CDC & ACOG recommended either orally or Intravaginally Metronidazole or Clindamycin is given to treat BV. To study the effectiveness of Clindamycin on Bacterial Vaginosis and compare with commonly used Metronidazole. A randomized control study was done after approval from Institute Ethical committee on patients who came to Gynaecology OPD in Shri Sathya Sai Medical College and Research Institute after taking written and informed consent.All study subjects were examined in the OPD. Under aseptic precautions a high vaginal swab was taken and sent to microbiology lab for culture and sensitivity and using the criterias mentioned below such as Amsel’s and Nugent’s, diagnosis will be noted and treated accordingly.Clindamycin is better than Metronidazole with respect to Amsel’s criteria and Nugent’s after treatment (P&#60;0.05) and with respect to the culture results after treatment (P&#60;0.05).Oral Clindamycin may be preferable to Oral Metronidazole because of its broader spectrum of activity.