bluuebunny/crossref_metadata_2025_split huggingface dataset:
EL MITO DE LA EXALTACIÓN DEL HOMBRE. ANTECEDENTES DE LA CRISTOLOGÍA DEL HIJO DEL HOMBRE JOÁNICO
Authors: Carbullanca César 
Published: July 2023

El artículo aporta antecedentes de la cristología joánica del Hijo del hombre. Éstos exponen aspectos del mito de la gloria de Yahvéh en forma humana y su exaltación en los cielos, existentes en tradiciones apocalípticas judías. La investigación mostrará, mediante un estudio de intertextualidad de textos apocalípticos judíos, la existencia de este mito de modo semejante a como lo encontraremos en el cuarto evangelio aplicado a la figura del Hijo del hombre. El estudio muestra esta tradición ligada a grupos apocalípticos que se plantean el problema de la trascendencia de Dios y su irrupción radical en la historia unida a la idea del martirio de su pueblo, de un mediador celeste descrito en términos antropomórficos, el cual sería exaltado, y que tendría a cargo la realización del juicio. No obstante que una respuesta definitiva a la cuestión de la vinculación de ambos temas queda remitido a un análisis sincrónico de los relatos joánicos, consideramos que estos antecedentes sugieren las las raíces apocalípticas de la encarnación y la cristología del Hijo del hombre joánico.
Enrique R. Moros, La vida humana como trascendencia: metafísica y antropología en la Fides et Ratio, Eunsa, Pamplona 2008; 413 pp. ISBN: 9788431325923.
Authors: Montoya Camacho Martin 
Published: July 2023

Llega a nosotros una obra filosófica, cuyo trabajo exploratorio a través de la naturaleza humana, nos permite observar la totalidad del ser desde una perspectiva antropológica. El libro La vida humana como trascendencia de Don Enrique R. Moros es un mapa del hombre, trazado en coordenadas metafísicas: verdad y libertad, fruto de una labor de confrontación con diferentes perspectivas filosóficas que, en la metáfora con la que nos conduce el autor, son aquellos mapas trazados por antiguos exploradores que, de alguna manera, dejaron indicado el norte adecuado para continuar esa labor.
Computational Structural Validation of CYP2C9 Mutations and Evaluation of
Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin
Authors: Sridharan Kannan , D Thirumal Kumar , Manikandan Suchetha , Prasanna Gaurav , Guruswamy Lalitha , Al Banna Rashed , Doss C George Priya 
Published: July 2023

Aim:
The study aimed to identify the key pharmacogenetic variable influencing the therapeutic outcomes
of warfarin using machine learning algorithms and bioinformatics tools.

Background:
Warfarin, a commonly used anticoagulant drug, is influenced by cytochrome P450 (CYP) enzymes,
particularly CYP2C9. MLAs have been identified to have great potential in personalized therapy.

Objective:
The purpose of the study was to evaluate MLAs in predicting the critical outcomes of warfarin therapy
and validate the key predictor genotyping variable using bioinformatics tools.

Methods:
An observational study was conducted on adults receiving warfarin. Allele discrimination method was
used for estimating the single nucleotide polymorphisms (SNPs) in CYP2C9, VKORC1, and CYP4F2. MLAs were
used for identifying the significant genetic and clinical variables in predicting the poor anticoagulation status (ACS)
and stable warfarin dose. Advanced computational methods (SNPs' deleteriousness and impact on protein destabilization,
molecular dockings, and 200 ns molecular dynamics simulations) were employed for examining the influence
of CYP2C9 SNPs on structure and function.

Results:
Machine learning algorithms revealed CYP2C9 to be the most important predictor for both outcomes compared
to the classical methods. Computational validation confirmed the altered structural activity, stability, and impaired
functions of protein products of CYP2C9 SNPs. Molecular docking and dynamics simulations revealed significant
conformational changes with mutations R144C and I359L in CYP2C9.

Conclusion:
We evaluated various MLAs in predicting the critical outcome measures associated with warfarin and
observed CYP2C9 as the most critical predictor variable. The results of our study provide insight into the molecular
basis of warfarin and the CYP2C9 gene. A prospective study validating the MLAs is urgently needed.
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of
[3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the
Treatment of Ischemic Stroke
Authors: Ge Xinyu , Zheng Yuandong , He Yifei , Chen Chong , Yang Chen , Lu Saiwei , Xuan Zhenyu , Zhong Dafang , Diao Xingxing 
Published: July 2023

Background:
Catalpol, one of the main bioactive components isolated from Rehmannia glutinosa, was
developed by Suzhou Youseen for the treatment of ischemic stroke; however, preclinical information about its absorption,
distribution, metabolism, and excretion (ADME) in animals is inadequate.

Objective:
This study aimed to illuminate the pharmacokinetics (PK), mass balance (MB), tissue distribution (TD),
and metabolism of catalpol after a single intragastric administration of 30 mg/kg (300 μCi/kg) [3H]catalpol in rats.

Methods:
Radioactivity in plasma, urine, feces, bile, and tissues was measured by liquid scintillation counting
(LSC), and metabolite profiling was characterized by UHPLC-β-ram and UHPLC-Q-Exactive plus MS.

Results:
The radio pharmacokinetic results showed that catalpol was rapidly absorbed by Sprague‒Dawley (SD) rats,
with a median Tmax of 0.75 h and an arithmetic mean half-life (t1/2) of the total radioactivity of approximately 1.52 h
in plasma. The mean recovery of the total radioactive dose was 94.82%±1.96% over 168 h postdose
(57.52%±12.50% in the urine and 37.30%±12.88% in the feces). The parent drug catalpol was the predominant drugrelated
substance in rat plasma and urine, while M1 and M2, two unidentified metabolites, were detected in feces.
When [3H]catalpol was incubated with β-glucosidase and rat intestinal flora, we found that the same metabolites M1
and M2 were produced in both incubation systems.

Conclusions:
Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated
in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine,
and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated
by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.
Addressing the Current Knowledge and Gaps in Research Surrounding
Lysergic Acid Diethylamide (LSD), Psilocybin, and Psilocin in Rodent
Models
Authors: Ezeaka Udoka C. , Kim Hye Ji J. , Laprairie Robert B. 
Published: July 2023

Abstract:
Lysergic acid Diethylamide (LSD), psilocybin, and psilocin are being intensively evaluated
as potential therapeutics to treat depression, anxiety, substance use disorder, and a host of
other psychiatric illnesses. Pre-clinical investigation of these compounds in rodent models forms a
key component of their drug development process. In this review, we will summarize the evidence
gathered to date surrounding LSD, psilocybin, and psilocin in rodent models of the psychedelic experience,
behavioural organization, substance use, alcohol consumption, drug discrimination, anxiety,
depression-like behaviour, stress response, and pharmacokinetics. In reviewing these topics, we
identify three knowledge gaps as areas of future inquiry: sex differences, oral dosing rather than injection,
and chronic dosing regimens. A comprehensive understanding of LSD, psilocybin, and
psilocin’s in vivo pharmacology may not only lead to their successful clinical implementation but
optimize the use of these compounds as controls or references in the development of novel
psychedelic therapeutics.
Facile Synthesis of Electron-deficient Epoxides Adjacent to Ester and
Cyanide Groups
Authors: Bhat Sujata V. , Uttekar Mayur , Gupta Manisha O. 
Published: July 2023

Abstract:
The addition of camphor and oxone® during the epoxidation led to the synthesis of seven
novel epoxides. Since the tri-substituted double bond of -cyano-cinnamates has been epoxidized, the
reaction is easier to carry out and cleaner, producing a high yield of epoxides. Several molecules with
industrial applications will result from the selective ring opening of epoxides.
Fault Diagnosis of Wind Turbine Bolts based on ICEEMD-SSA-SVM Model
Authors: Ge Qianhua , Wang Dexing , Sun Kai , Wang Dongli 
Published: July 2023

Background:
Compared with traditional power generation systems, wind turbines have more units and work in a more harsh environment, and thus have a relatively high failure rate. Among blade faults, the faults of high-strength bolts are often difficult to detect and need to be analyzed with high-precision sensors and other equipment. However, there is still little research on blade faults.

Methods:
The improved complete ensemble empirical mode decomposition (ICEEMD) model is used to extract the fault features from the time series data, and then combined with the support vector machine optimized by sparrow search algorithm (SSA-SVM) to diagnose the bolt faults of different degrees, so as to achieve the purpose of early warning.

Results:
The results show that the ICEEMD model used in this paper can extract the bolt fault signals well, and the SSA-SVM model has a shorter optimization time and more accurate classification compared with models such as PSO-SVM.

Conclusion:
The hybrid model proposed in this paper is important for bolt fault diagnosis of operation monitoring class.
Association between Cardiac Atrioventricular Conduction and Antibodies
to Chlamydia Pneumoniae in Fibromyalgia Patients
Authors: Puri Basant K. , Tuckey Georgia , Cowans Lucy , Lee Gary S. , Schwarzbach Armin 
Published: July 2023

Background:
Fibromyalgia patients may complain of cardiovascular symptoms, including
chest pain and palpitations. It has been proposed that infection by Chlamydia pneumoniae
might be common in fibromyalgia. Chlamydia pneumoniae infection has also been hypothesized
to be a causative factor in cardiac disease.

Objective:
This study aims to test the hypothesis that there is an association between atrioventricular
conduction and antibodies to Chlamydia pneumoniae in fibromyalgia.

Methods:
Thirteen female fibromyalgia patients underwent serum Chlamydia pneumoniae IgG
assays and 12-lead electrocardiography in a cross-sectional study. None of the patients was taking
medication which might affect atrioventricular conduction, and none suffered from hypothyroidism,
renal disease, hepatic disease, or carotid hypersensitivity.

Results:
There was a significant positive correlation between the PR interval duration and the serum
Chlamydia pneumoniae IgG level (r = 0.650; p = 0.016).

Conclusion:
This study supports the hypothesis of an association between atrioventricular conduction
and antibodies to Chlamydia pneumoniae in fibromyalgia patients. It suggests that the higher
the level of such antibodies, the greater the electrocardiographic PR interval, and therefore the
slower the atrioventricular conduction. Potential pathophysiological mechanisms include a chronic
inflammatory response to Chlamydia pneumoniae and the action of the bacterial lipopolysaccharide.
The latter may involve stimulators of interferon genes, activation of the cardiac NOD-like
receptor protein 3 inflammasomes, and downregulation of fibroblast growth factor 5 in the heart.
Islamic Banking Loyalty in Indonesia: The Role Brand Image, Promotion, and Trust
Authors: Basrowi Basrowi , Ali Juhary , Suryanto Tulus , Utami Pertiwi 
Published: July 2023

This study aims to investigate the impact of brand image and promotion on customer loyalty in Islamic banking in Indonesia, with trust serving as a moderator variable. Specifically, the research aims to accomplish two objectives: (1) to examine the direct influence of brand image and promotion on trust and customer loyalty and (2) to investigate the indirect effect of brand image and promotion on customer loyalty through trust. The data were collected from 150 customers of Bank Syariah Indonesia, located in Jakarta Lenteng Agung Branch. To ensure the robustness of its findings, a rigorous quantitative analysis was conducted, utilizing structural equation modeling (SEM) and Smart PLS 3.3. The results indicate that each of the investigated variables holds statistical significance. In particular, it also reveals a partial direct relationship of brand image and promotion on trust. Moreover, the findings suggest that brand image and promotion have a significant influence on customer loyalty, either directly or indirectly through trust. Additionally, the study demonstrates a clear association between trust and customer loyalty. One of the original contributions of this study is the identification of trust's substantial mediating role in the relationship between brand image and promotion on customer loyalty at Bank Syariah Indonesia, Jakarta Lenteng Agung Branch.========================================================================================================ABSTRAK – Loyalitas Nasabah pada Perbankan Syariah di Indonesia: Peran Citra Merek, Promosi, dan Kepercayaan. Tujuan pada penelitian ini adalah untuk menganalisis pengaruh citra merek dan promosi terhadap kepercayaan, dimana kepercayaan sebagai moderatornya. Secara khusus, kajian ini mengkaji: 1) pengaruh citra merek dan promosi terhadap kepercayaan dan kepuasan pelanggan, dan 2) pengaruh tidak langsung dari citra merek dan promosi terhadap loyalitas pelanggan yang dimoderasi oleh kepercayaan. Data primer diperoleh melalui survey kepada 150 sampel nasabah pada Bank Syariah Indonesia KCP Jakarta Lenteng Agung. Untuk melakukan analisis kuantitatif yang bagus, kajian ini menggunakan pendekatan structural equation modeling (SEM) dan Smart PLS 3.3. Temuan kajian menunjukkan bahwa masing-masing variabel yang diteliti secara statistik menghasilkan nilai yang signifikan. Secara parsial, ada hubungan langsung antara citra merek dan promosi terhadap kepercayaan. Faktor-faktor tersebut juga berpengaruh signifikan terhadap loyalitas pelanggan, baik secara langsung maupun tidak langsung melalui kepercayaan. Selain itu, penelitian ini juga menunjukkan adanya hubungan yang nyata antara kepercayaan dan loyalitas pelanggan. Penelitian ini berkontribusi dalam mengidentifikasi signifikansi fungsi mediasi dari variabel kepercayaan pada hubungan antara citra merek dan promosi terhadap loyalitas pelanggan Bank Syariah Indonesia KCP Jakarta Lenteng Agung.
Tindak Pidana Penghinaan Lambang Negara Perspektif Hukum Positif dan Hukum Islam
Authors: Ikhsan Daimul , Fatojanah Anindita Ari , Wulandari Bety , Fitri Nur Hana , Utami Khoirunnisa 
Published: July 2023

This article was written to examine the action of national identity humiliation that recently happens, considered from the perspective of positive and Islamic law. Using descriptive approach method by analyzing the sources that relevant with the positive and Islamic law. From the analysis of the collected data, shows that the action of national identity humiliation is categorized as criminal action. Every citizen should appreciate and respect to the national symbol as the patriotism actualization.Â Keywords :National identity humiliation, Positive-law, Islamic-lawÂ
STUDI KASUS TENTANGDINAMIKA RESILIENSI REMAJA DENGAN KELUARGA BROKEN HOME
Authors: Nurulita Nia , Susilowati Rita Kurnia 
Published: July 2023

This study aims to determine the dynamic picture of adolescent resilience with broken home families. This study uses qualitative research methods with a case study approach. The results showed that respondents showed resilience dynamics tend to be the same, namely the formation of resilience based on individual learning processes of the problems faced, the ability of individuals to evaluate every action taken and the spiritual aspect of getting closer to God so that making religious values as a guide to life . Meanwhile subjects who have an optimistic ability and self-efficacy that have not been good, this is due to the learning process of individuals to deal with problems that are still developing, individual fears about their experiences of broken home families cause the difficulty of individuals to have the ability of optimism and efficacy well, this causes adolescents tend to doubt their abilities, thinking that the problems they face will occur in the future.Keywords:Â Resilience; Youth; Broken Home Family
NILAI-NILAI PROFETIK DALAM PENGEMBANGAN LASIZAWA DESA PONGGOK
Authors: Mubarok Muhammad Fikri , Suryani Firda Imah 
Published: July 2023

This paper objectives to understand prophetic values have accepted from Prophetic Social Sciences (ISP) in LasiZawaâ€™s Development Strategy. The Prophetic Values have accept to be research variabel because the significancy of basic LasiZawa Development so close with religious life that make dialectic for village society. This research used qualitative approach, the research methode using case studies. The collect data methode with in depth interview with LasiZawaâ€™s Commitee, Village Chairman and observation. This paper conclude that there is a dialectic of social reality that is not ideal in transformation of Ponggok Tourism Village. The establisment of LasiZawa which is a response to this social reality. The newness of this tesearch lies in the institutionalization of ZISWAF institution by village government and managed independently and upholding prophetic values.Keywords:Â Prophetic Value; LasiZawa; Ponggok Village
ANALISIS LAYANAN PENINGKATAN KUALITAS HIDUP ORANG DENGAN GANGGUAN JIWA (ODGJ)
Authors: Winarno Bambang Suko 
Published: July 2023

There are many service models with various types of programs to improve the quality of life for mental patients. Rehabilitation centers already exist in various Indonesian cities with their social workers trying to implement therapy programs for healing and improving the quality of life for ODGJ patients. Therefore, the researcher wants to analyze in more detail what service programs are provided by social workers in rehabilitation places which will later be used as a reference material for social workers, the general public, counselors, psychologists, and academics. The method used by researchers is to use a library research method or approach (library research) or literature study where the researcher collects library data, then reads and studies to find research material. Research result. The results showed that ODGJ rehabilitation services were vocational, recreational therapy, occupational therapy, and ruqyah therapy.Keywords:Â Â quality of life; service improvement; patients with mental illness
PERAN DAKWAH DARING UNTUK MENJAGA SOLIDARITAS SOSIAL DI MASA PANDEMI COVID 19
Authors: Setyowati Setyowati , Cahya Anggi 
Published: July 2023

The pandemic state demands the limitation of face-to-face social processes for spiritual needs through da'wah which is likely to be the intake for most of the Muslim community, especially in the IAIN Surakarta environment. This study analyzes da'wah which is carried out online which can be one of the performances to achieve social solidarity. Methods of data collection through interviews and observations. This research method is descriptive qualitative on phenomenology. The results of this study show that from the implementation of preaching KR and HM have adjusted their needs during the pandemic, namely by doing it online so that DE and FA can still study by optimizing social restrictions and implementing health protocols. This is a form of mutual concern which is an instrument of public compliance to build a sense of solidarity during a pandemic.Keywords:Â Social Solidarity; Dawah; Online; Pandemi
CITRA PEREMPUAN DALAM IKLAN POLITIK PUAN "KEPAK SAYAP KEBHINEKAAN"
Authors: Ariyanto Panji , Afina Meida N , Ghoni Abdul , Khusna Amanda 
Published: July 2023

In terms of quantity, women are rarely represented in political advertisements. In line with that, studies on how female figures are imaged in political advertisements are minimal. This study aims to provide an understanding of how women (Puan Maharani) are imaged in the political advertisement "Kepak Sayap Kebhinekaan" through the point of view of Roland Barthes' semiotic study. This study uses a qualitative approach by utilizing semiotic analysis. In the political advertisement "Kepak Sayap Kebhinekaan", women, in this case, Puan Maharani, are portrayed as having power as political leaders. In addition, women are portrayed as leaders who are nationalists, revolutionaries, protectors, guardians of diversity and deserve respect. The red color and the kebaya as a sign in Puan Maharani's political advertisement also have a negative connotation, namely opening up the perspective of female leaders with a communist stigma and lack of Islam.
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Keywords: Political Advertisement; Representation; Woman
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ANALISIS FAKTOR-FAKTOR PENGHAMBAT PENYELESAIAN SKRIPSI MAHASISWA UIN RADEN MAS SAID SURAKARTA
Authors: Khoirunnisa Afifah , Putri Rahmawati Permatasari Devi , Nisa Izzatun , Ulfa Nahdiyana Miladiya , Misbakhul Munir Muhamad , Arofatul Jannah Ulum 
Published: July 2023

Writing a thesis is one of the problems in completing student studies. Based on the results of observations, there are still many students of UIN Raden Mas Said who have not completed their thesis on time. This research is a descriptive qualitative research that aims to describe the inhibiting factors in the completion of the thesis. The subjects in this study were students of UIN Raden Mas Said who had not graduated with a study period of more than four years. The results showed that there were 9 factors that hindered the completion of the script. Of the 9 factors, researchers grouped into 2 factors, namely internal factors and external factors. Internal factors in the form of physical and mental health and academic ability. While external factors in the form of lecturer guidance and references, the environment of friends and family and other activities.
Keywords: internal factor; external factor; finishing the thesis undergraduate
PENERAPAN E-BUSINESS DALAM RANGKA MEMAJUKAN STRATEGI PEMASARAN PRODUK UMKM
Authors: Afifah Yeni Asari Umi , Astutik Puji , Ariyanti Novi , Nindiya Agustina Ratna , Parwati Indah 
Published: July 2023

Micro, Small and Medium Enterprises (MSMEs) play an important role in the Indonesian economy. However, marketing problems are the main obstacle for the MSME business at this time, the marketing system which is still traditional in nature makes it difficult for MSME businesses to spread their wings to various regions. This study aims to find out how far people understand E-Business and find out whether E-Business can attract consumer interest and help market products to a wider realm. The method used in this research is qualitative method. The data collection technique is by in-depth interviews with one of the MSME business actors in the villages of Wungusari, Tegaldowo, Gemolong, Sragen directly and literature studies, then the results of the interviews are stored in recorded form and transcribed completely. The results obtained are that public knowledge about E-Business is still very lacking and this is due to the lack of education to several MSME business actors and the public as consumers. E-Business can help marketers attract consumer interest and make it easier for consumers to get the products they want, besides that E-Business also makes it easier for MSME business players to market their products widely to various regions and even between countries. So it can be concluded that the application of E-Business can provide great opportunities for MSME businesses in developing their products and assisting MSME businesses in increasing income both locally and nationally.
Keywords: E-Business; Marketing; MSME