bluuebunny/crossref_metadata_2025_split huggingface dataset:
AZERBAYCAN’IN TARİHİ MİMARLIK ABİDESİ ŞEKİ HAN SARAYINDA VE GELENEKSEL EL DOKUMALARINDA KUŞ TASVİRLERİ
Authors: MAMMADOVA Arzu 
Published: January 2023

Azerbaycan dünyanın en eski yerleşim ve kültür merkezlerinden biridir. Çok zengin ve güzel bir iklime sahip olan Azerbaycan topraklarının doğası gereği, eski çağlardan beri burada insanlar yaşamıştır. Azıh mağarasında bulunan ve azykhantrop adı verilen adamın çene kemiği, Azerbay- can’ın dünyanın en eski ilkel yerleşim yerlerinden biri olduğunu kanıtlıyor. Gobustan’da keşfedilen yerleşim yerleri ve kayaüstü resimler bu bölgede eski çağlardan beri insanların yaşadığını doğrulamaktadır.
Tarihi süreçlerde ülkemiz topraklarında şehirler, savunma yapıları ve muhteşem kale duvarları, saraylar vs inşa edilmiştir.
Ortaçağ anıtları (Mömine Hatun, Karabağlar, Gülistan, Berde türbeleri, Şirvanşahlar sarayı, Şeki Han sarayı, Şuşa abideleri vb.) Doğu ve dünya mimarisinin en güzel incilerindendir.
Azerbaycan’da geleneksel el dokumaları denildiyi zaman ise halı en önde gelen dokumalardan biri sayılır. Halılar azerbaycanlıların yaşam şekli, geleneği, inancı ve sosyal durumu ile sıkı sıkıya bağlıdır. Mimarı yapılar kerpıc ve taşlarla belli bir sıralamayla inşa edilirken dokumalar da ipliklerle ilmek ilmek dokunarak iç mekanlara sıcaklık ve renk katmış, günlük kullanım eşyalarının vazgeçilmezlerinden olmuştur.
Mimaride ve geleneksel dokumalarda motifler ve süslemeler önemli bezeme unsurlarıdır.
Bu bağlamda 18. yüzyıl Azerbaycan mimarisinin incilerinden biri olarak kabul edilen Şeki Han Sarayı, özgün estetiği ile kurgulanmış duvar resimleri ve süsleme kompozisyonu ile önemlidir. Şeki Han Sarayı iç duvarlarında ve Azərbaycanın geleneksel el dokumalarındakı kompozisyonlarda geometrik ve bitkisel motiflerle yanaşı hayvan ve kuş figürlerinın de önemli süsleme elementleri olduğu görülmektedir.
Bu araştırmada önemli kültürel değerlerimizden biri olan Şeki Han Sarayının iç duvar kompozisyonlarında ve geleneksel el dokumalarında kullanılan kuş figürleri incelenmiştir.
Bildiri çizim ve görsellerle zenginleştirilmiştir.
Gastrointestinal Parasitism and Anthelmintic Efficacy In Cattle From Fulbaria Upazila of Mymensingh, Bangladesh
Authors: Sohan Md Humayun , Shohana Nusrat Nowrin , Rony Sharmin Aqter , Dey Anita Rani , Akter Shirin , Alim Md Abdul , Alam Mohammad Zahangir 
Published: January 2023

Gastrointestinal parasitism and anthelmintic efficacy are of global concern for livestock and public health. An investigation on cattle gastrointestinal parasites and anthelmintic efficacy was conducted at Fulbaria Upazila, Mymensingh in 2017. Out of 100 fecal samples examined using simple sedimentation method, 70% cattle were found positive for parasites. The identified parasites were Paramphistomum spp. (27%), Fasciola gigantica (15%), Schistosoma spp. (10%), Haemonchus spp. (14 %) and Balantidium coli (12%). No significant variation was found in the prevalence rate between young (<2 years) and adult cattle (≥ 2 years). Significantly higher infection rate was recorded in male (81.63%) and in poor body conditioned animals (95.83%). For anthelmintic efficacy, feces from 50 animals were screened for eggs per gram (EPG) using McMaster technique. Twenty four cattle (>200 EPG) were allotted equally into three groups and further treated with either albendazole or ivermectin or kept as untreated control. EPG were again estimated for those animals at 14 days post-treatment. Status of anthelmintic efficacy was determined by using the fecal egg count reduction percentage (FECR %) test. The FECR % for albendazole and ivermectin were 98.76% and 95.01%, respectively. Results from this study indicated high parasitism in the study area and relatively higher efficacy of albendazole compared to ivermectin. Further studies are necessary to rule out the possibilities of anthelmintic resistance to parasites in cattle throughout the country as early as possible with a view to increase farmer awareness and to develop effective control strategies against endoparasites.
Vol. 9, No. 3, December 2022: 289-297
Effect of Traditional Cooking Method on the Heavy Metal Content of Four Selected Farmed Carp Species And Assessment of Possible Human Health Risk
Authors: Ghosh Jibon Kumar , Islam Md Shahidul , Islam Md Tariqul , Murad Md Mahedul Islam , Rahman Md Mahabubur 
Published: January 2023

The present study was conducted to evaluate the effect of traditional Bengal culinary practice on the heavy metal content of four carp species (Labeo rohita, Catla catla, Cirrhinus cirrhosus, and Hypophthalmichthys molitrix). Fish samples were collected from seven different farms located in the Rajshahi district of Bangladesh. The collected samples were processed and cooked in a traditional currying method and concentrations of five heavy metals (Pb, Co, Cr, Cd, and Ni) were assessed in raw and cooked fish using a flame atomic spectrophotometer. Heavy metal concentrations were significantly reduced in the cooked samples with a few exceptions. The metal pollution index (MPI) indicated that the most amount of heavy metals was lost in C. cirrhosus followed by H. molitrix, L rohita, and C. catla. Pb was the most abundant and consumed of the tested heavy metals in the cooked fish followed by Co, Ni, Cd, and Cr respectively. Health risk index (HRI) and target hazard quotient (THQ) revealed that individual heavy metal intake from cooked fish does not pose any threat to human health. However, the hazard index (HI) of the accumulated heavy metals in the cooked fish suggested that the long-term effect of consuming heavy metal contaminated fish could collectively lead to possible non-carcinogenic health complexities. Additionally, HI also implied that the highest degree of health risk is associated with the consumption of H. molitrix and the least with L. rohita.
Vol. 9, No. 3, December 2022: 367-376
Estoque de carbono em frações dessimétricas da matéria orgânica no solo em diferentes sistemas de uso na Amazônia Oriental
Authors: Souza Alcione Santos de , Freitas Luis de Souza , Galvão Jessivaldo Rodrigues 
Published: January 2023

Estudos têm demonstrado que determinados compartimentos da MOS são capazes de detectar transformações nos conteúdos de C no solo com manejo, ou seja plantios com ou sem queima, entretanto são capazes de detectar, mais rapidamente, as reduções constatadas são, de modo geral, maiores que as observadas, considerando, assim, o conteúdo total de C do solo. O trabalho teve como objetivo avaliar estoque de carbono das frações densimétricas em diferentes sistemas, o estudo foi realizado na Amazônia Oriental, Nordeste do Pará, em Igarapé-Açu, solo Latossolo Amarelo, em áreas experimentais das comunidades de Cumaru, Nova Olinda (em propriedades de pequenos produtores rurais) e UFRA-FEIGA. Os sistemas de uso consistem em 06 (seis) tratamentos, que são: T1 CC (Cumaru Capoeira), T2 CSQT (Cumaru sem queima triturado), T3 CQ (Cumaru queima), T4 UFC (UFRA Capoeira), T5 UFSQT (UFRA sem queima triturado), T6UFQ (UFRA queima). Bem como, algumas SAFs. Retirou-se amostras dos solos nas profundidades 0-5 cm, 5-10 cm e 10-20 cm. Separou-se as frações densimétricas para a determinação de teores de carbono por combustão em analisador elementar LECO CHN-S TRUSTEC, as variáveis foram submetidas à análise de variância, comparadas pelo teste de SNK com programa estatístico SISVAR. A fração que estocou carbono foi a leve livre nos sistemas onde não ocorreram queima, com sua sensibilidade do sistema de manejo do solo, onde houve maior revolvimento desta fração se fez menos presente. A fração leve, livre concentrou estocando mais carbono que a fração oclusa em função dos seus diferentes mecanismos e composição química.
Bio-SCAN V2: A CRISPR/dCas9-based lateral flow assay for rapid detection of theophylline
Authors: Jiang Wenjun , Aman Rashid , Ali Zahir , Mahfouz Magdy 
Published: January 2023

Rapid, specific, and robust diagnostic strategies are needed to develop sensitive biosensors for small molecule detection, which could aid in controlling contamination and disease transmission. Recently, the target-induced collateral activity of Cas nucleases [clustered regularly interspaced short palindromic repeats (CRISPR)-associated nucleases] was exploited to develop high-throughput diagnostic modules for detecting nucleic acids and small molecules. Here, we have expanded the diagnostic ability of the CRISPR-Cas system by developing Bio-SCAN V2, a ligand-responsive CRISPR-Cas platform for detecting non-nucleic acid small molecule targets. The Bio-SCAN V2 consists of an engineered ligand-responsive sgRNA (ligRNA), biotinylated dead Cas9 (dCas9-biotin), 6-carboxyfluorescein (FAM)-labeled amplicons, and lateral flow assay (LFA) strips. LigRNA interacts with dCas9-biotin only in the presence of sgRNA-specific ligand molecules to make a ribonucleoprotein (RNP). Next, the ligand-induced ribonucleoprotein is exposed to FAM-labeled amplicons for binding, and the presence of the ligand (small molecule) is detected as a visual signal [(dCas9-biotin)-ligRNA-FAM labeled DNA-AuNP complex] at the test line of the lateral flow assay strip. With the Bio-SCAN V2 platform, we are able to detect the model molecule theophylline with a limit of detection (LOD) up to 2 μM in a short time, requiring only 15 min from sample application to visual readout. Taken together, Bio-SCAN V2 assay provides a rapid, specific, and ultrasensitive detection platform for theophylline.
Determination of nicotine in newborn meconium by high-Resolution ambient mass spectrometry using wooden-Tip spray
Authors: Wang Xinrong , Yang Mingyu , Xiao Hui , Liu Danping , Pan Lu , Zhang Liuyang , Yang Yan , Lu Qing , Liu Yanqiu , Yang Xiao , Yang Bicheng 
Published: January 2023

Prenatal exposure to nicotine that are mainly produced from tobacco smoke has been reported to affect infants. Therefore, nicotine exposure is one of important health concerns for newborn screening. Detecting nicotine and its metabolites such as cotinine in meconium were widely used to evaluate the tobacco exposure of pregnancy. In this study, disposable wooden tips were applied for touch sampling of meconium from newborn infants, and then were directly mounted on mass spectrometer (MS) to perform rapid screening of nicotine and cotinine. Choice of extraction/spray solvents was optimized. The limits of detection, reproducibility, linear response for direct analysis of meconium were also investigated. It is found the limits of detection (S/N = 3) to be as low as 0.36 ng/mg and 1.18 ng/mg for nicotine and cotinine, respectively, while the limits of quantitation (S/N = 10) to be 1.19 ng/mg and 3.94 ng/mg for nicotine and cotinine, respectively. The relative standard deviations (RSD) were found to be at 8.4%–19.8% (n = 6) for nicotine and cotinine, a good linear range from 5–500 ng/mL (R2 &gt; 0.99). These analytical performances are well-accepted levels for ambient mass spectrometer analysis. In this study, evaluation of nicotine and cotinine in 22 puerpera volunteers were conducted by the established wooden-tip spray mass spectrometry (WTS-MS). These results showed that wooden-tip spray mass spectrometry would be useful for newborn screening of nicotine and cotinine in meconium with high reproducibility, speed, sensitivity, and specificity. Owing to the use of disposable wooden tips that involves no sample preparation and no chromatographic separation, our results show that wooden-tip spray mass spectrometry is a powerful tool for determination of nicotine in newborn meconium.
Physiological and transcriptome analysis of Candida albicans in response to X33 antimicrobial oligopeptide treatment
Authors: Lu Qunlin , Wang Yuanxiu , Liao Xing , Zhou Fu , Zhang Bin , Wu Xiaoyu 
Published: January 2023

IntroductionCandida albicans is an opportunistic pathogenic fungus, which frequently causes systemic or local fungal infections in humans. The evolution of its drug-resistant mutants necessitate an urgent development of novel antimicrobial agents.ResultsHere, we explored the antimicrobial activity and inhibitory mechanisms of X33 antimicrobial oligopeptide (X33 AMOP) against C. albicans. The oxford cup test results showed that X33 AMOP had strong inhibitory activity against C. albicans, and its MIC and MFC were 0.625 g/L and 2.5 g/L, respectively. Moreover, SEM and TEM showed that X33 AMOP disrupted the integrity of cell membrane. The AKP, ROS, H2O2 and MDA contents increased, while the reducing sugar, soluble protein, and pyruvate contents decreased after the X33 AMOP treatment. This indicated that X33 AMOP could damage the mitochondrial integrity of the cells, thereby disrupting the energy metabolism by inducing oxidative stress in C. albicans. Furthermore, transcriptome analysis showed that X33 AMOP treatment resulted in the differential expression of 1140 genes, among which 532 were up-regulated, and 608 were down-regulated. These DEGs were related to protein, nucleic acid, and carbohydrate metabolism, and their expression changes were consistent with the changes in physiological characteristics. Moreover, we found that X33 AMOP could effectively inhibit the virulence attributes of C. albicans by reducing phospholipase activity and disrupting hypha formation.DiscussionThese findings provide the first-ever detailed reference for the inhibitory mechanisms of X33 AMOP against C. albicans and suggest that X33 AMOP is a potential drug candidate for treating C. albicans infections.
Prognostic value of remnant cholesterol in patients with coronary heart disease: A systematic review and meta-analysis of cohort studies
Authors: Tian Yun , Wu Wenli , Qin Li , Yu Xiuqiong , Cai Lin , Wang Han , Zhang Zhen 
Published: January 2023

BackgroundThe relationship between abnormal lipid levels and atherosclerotic cardiovascular diseases is well established, but the association between remnant cholesterol (RC) and coronary heart disease (CHD) remains uncertain. The aim of this meta-analysis is to systematically evaluate the prognostic value of RC concentration in patients with CHD.MethodsPubMed, EMBASE, Cochrane, and Web of Science databases were reviewed to identify relevant observational cohort studies published in English up to December 2021. Random-effects meta-analysis compared the highest and lowest RC concentration. The primary outcome was a composite of major adverse cardiovascular events (MACEs) and all-cause mortality in patients with CHD.ResultsA total of 10 studies recruiting 30,605 patients with CHD were selected to be included in this meta-analysis. Patients with CHD with elevated RC concentration had an increased risk of the composite endpoint events (RR = 1.54, 95% CI: 1.26–1.87) and MACEs (RR = 1.70, 95% CI: 1.54–1.88), but the risk of all-cause mortality was not statistically significant (RR = 1.16, 95% CI: 0.79–1.69, P = 0.44). Subgroup analysis showed consistent results.ConclusionOur results suggest that elevated concentration RC may independently predict MACEs in patients with CHD. Determination of RC concentration may improve risk stratification of prognosis in patients with CHD. However, more high-quality studies are necessary to confirm this association.
The relationship between pre-operative right ventricular longitudinal strain and low-cardiac-output syndrome after surgical aortic valve replacement
Authors: Zhang Yong-jian , Chen Hong , Dong Ya-ling , Shang Jia-nan , Ruan Li-tao , Yan Yang , Song Yan 
Published: January 2023

ObjectivesThis study was performed to investigate the relationship between right ventricular free wall longitudinal strain (RVFWSL) and low cardiac output syndrome (LCOS) after surgical aortic valve replacement (SAVR) and to further explore its association with readmission within 2 years in patients who developed LCOS after SAVR.MethodsThis single-center retrospective observational study involved consecutive patients who underwent SAVR at our hospital from May 2018 to June 2020. Preoperative echocardiography was obtained within 3 days before SAVR. The longitudinal strain of the right ventricle was analyzed using the right ventricle as the main section, and the RVFWSL and right ventricular four-chamber longitudinal strain (RV4CSL) were obtained. The primary observation was the occurrence of LCOS. The secondary prognostic indicators were mainly the readmission rates within 2 years.ResultsIn total, 146 patients were finally included in this study. The RVFWSL was significantly lower in the LCOS group than in the No-LCOS group (16.63 ± 2.10) vs. (23.95 ± 6.33), respectively; P &lt; 0.001). The multivariate regression analysis showed that the RVFWSL was associated with LCOS (odds ratio, 1.676; 95% confidence interval, 1.258–2.232; P &lt; 0.001). The receiver operating characteristic curve showed that the cut-off value for RVFWSL to predict LCOS was less than –18.3, with an area under the curve of 0.879, sensitivity of 100%, and specificity of 80.47%. The multivariate regression analysis showed that LCOS was an independent risk factor for readmission within 2 years in patients undergoing SAVR.ConclusionPatients with RVFWSL (&lt;-18.3%) may be an increased risker for LCOS after SAVR. The occurrence of LCOS after SAVR is Yong-jian Zhang a risk factor for readmission within 2 years. Right ventricular function monitoring may have some predictive value for the postoperative prognosis in patients undergoing SAVR.
Quantification of paravalvular leaks associated with TAVI implants using 4D MRI in an aortic root phantom made possible by the use of 3D printing
Authors: Aigner Philipp , Sella Bart Eleonora , Panfili Sebastiano , Körner Tito , Mach Markus , Andreas Martin , Königshofer Markus , Saitta Simone , Redaelli Alberto , Schmid Albrecht , Moscato Francesco 
Published: January 2023

IntroductionTranscatheter aortic valve implantation (TAVI) has become an alternative to surgical replacement of the aortic valve elderly patients. However, TAVI patients may suffer from paravalvular leaks (PVL). Detecting and grading is usually done by echocardiography, but is limited by resolution, 2D visualization and operator dependency. 4D flow magnetic resonance imaging (MRI) is a promising alternative, which did not reach clinical application in TAVI patients. The aim of this study was applying 3D printing technologies in order to evaluate flow patterns and hemodynamics of PVLs following TAVI, exploiting 4D flow MRI and standard ultrasound.Materials and methodsAn MR-compatible, anatomically left ventricle, aortic root, and ascending aorta model was fabricated by combining 3D-printed parts and various soft silicone materials to match physiological characteristics. An Abbott Portico™ valve was used in continuous antegrade flow (12–22 l/min), retrograde flow with varying transvalvular pressures (60–110 mmHg), and physiological pulsatile hemodynamics (aortic pressure: 120/80 mmHg, cardiac output: 5 l/min) Time-resolved MR measurements were performed above and below the TAVI stent and compared with color Doppler ultrasound measurements in exactly the same setup.ResultsThe continuous antegrade flow measurements from MRI largely agreed with the flowmeter measurements, and a maximum error of only 7% was observed. In the retrograde configuration, visualization of the paravalvular leaks was possible from the MR measurements, but flow was overestimated by up to 33%. The 4D MRI measurement in the pulsatile setup revealed a single main PVL, which was also confirmed by the color Doppler measurements, and velocities were similar (2.0 m/s vs. 1.7 m/s).Discussion4D MRI techniques were used to qualitatively assess flow in a patient-specific, MR-compatible and flexible model, which only became possible through the use of 3D printing techniques. Flow patterns in the ascending aorta, identification and quantification of PVLs was possible and the location and extent of PVLs were confirmed by ultrasound measurements. The 4D MRI flow technique allowed evaluation of flow patterns in the ascending aorta and the left ventricle below the TAVI stent with good results in identifying PVLs, demonstrating its capabilities over ultrasound by providing the ability to visualize the paravalvular jets in three dimensions at however, additional expenditure of time and money.
Centrifugal model tests and numerical modeling on overtopping-induced breach processes of landslide dams
Authors: Zhang Lucheng , Zhong Qiming , Yang Meng , Peng Ming , Liu Jiaxin , Mei Shengyao , Yan Zhikun , Shan Yibo 
Published: January 2023

This study used the 400 g-ton geotechnical centrifuge model test system at the Nanjing Hydraulic Research Institute (NHRI) to investigate the breach evolution characteristics and hydrograph process of overtopping-induced breaching of landslide dams. It was achieved by taking advantage of the “time-space amplification” effect created by high-speed rotation using a centrifuge overweight force field. The effects of dam height, slope ratio, and soil gradation on the overtopping failure process of landslide dams were investigated by centrifugal model tests for the first time. In addition, a detailed physically-based dam breach model was developed to simulate the overtopping failure of landslide dams. Results show that the breach process of a landslide dam can be divided into four stages based on the measured breach morphology evolution process and the abrupt variations of breach flow discharge: initial scour on the downstream slope, retrogressive erosion to the dammed lake, erosion along the breach channel, and breach stabilization. Moreover, the peak breach flow is most sensitive to the dam height, followed by the average particle size; the time to peak is mainly affected by the slope ratio, and the relative residual dam height is primarily susceptible to the average particle size. In practice, the calculated results are consistent with the measured results. This study provides a scientific reference for the cognition of the overtopping-induced breach mechanism of landslide dams.
The strength law of coir fiber-reinforced soil based on modified Duncan-Chang model
Authors: Yang Hui , Li Penghui , Yang E , Jiang Xueliang , Chen Jiayu 
Published: January 2023

A large diameter triaxial sample of 61.9 mm was made by adding coir fiber into red clay. The range of confining pressure was 50–200 kPa; fiber content was 0.1%–0.4%; and fiber length was 10–40 mm. By varying the confining pressure, fiber content and fiber length, the unconsolidated and undrained triaxial tests were used to study the shear strength variation law of coir fiber-reinforced soil. The experimental data were processed to establish a linear model of the segmental elastic modulus, and linear analysis was used to determine the model fitting parameters and to improve the Duncan-Chang model by combining the concept of damage ratio. The modified Duncan-Chang model fits the stress-strain relationship of coir-reinforced soil. The results show a clear dividing line for the effect of fiber length and fiber content on the strength of the samples, which is about 30 mm and 0.3%, respectively. At the same time, the modified model can fit the stress-strain relationship of coir fiber-reinforced soil and reflect the stress-strain curve characteristics of coir fiber-reinforced soil.