bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a novel definitive scoring system for an enteral feed-only model of necrotizing enterocolitis in piglets
Authors: Ragan Mecklin V. , Wala Samantha J. , Sajankila Nitin , Duff Audrey F. , Wang Yijie , Volpe Samuel G. , Al-Hadidi Ameer , Dumbauld Zachary , Purayil Nanditha , Wickham Joseph , Conces Miriam R. , Mihi Belgacem , Goodman Steven D. , Bailey Michael T. , Besner Gail E. 
Published: April 2023

IntroductionNecrotizing enterocolitis (NEC) is a complex inflammatory disorder of the human intestine that most often occurs in premature newborns. Animal models of NEC typically use mice or rats; however, pigs have emerged as a viable alternative given their similar size, intestinal development, and physiology compared to humans. While most piglet NEC models initially administer total parenteral nutrition prior to enteral feeds, here we describe an enteral-feed only piglet model of NEC that recapitulates the microbiome abnormalities present in neonates that develop NEC and introduce a novel multifactorial definitive NEC (D-NEC) scoring system to assess disease severity.MethodsPremature piglets were delivered via Caesarean section. Piglets in the colostrum-fed group received bovine colostrum feeds only throughout the experiment. Piglets in the formula-fed group received colostrum for the first 24 h of life, followed by Neocate Junior to induce intestinal injury. The presence of at least 3 of the following 4 criteria were required to diagnose D-NEC: (1) gross injury score ≥4 of 6; (2) histologic injury score ≥3 of 5; (3) a newly developed clinical sickness score ≥5 of 8 within the last 12 h of life; and (4) bacterial translocation to ≥2 internal organs. Quantitative reverse transcription polymerase chain reaction was performed to confirm intestinal inflammation in the small intestine and colon. 16S rRNA sequencing was performed to evaluate the intestinal microbiome.ResultsCompared to the colostrum-fed group, the formula-fed group had lower survival, higher clinical sickness scores, and more severe gross and histologic intestinal injury. There was significantly increased bacterial translocation, D-NEC, and expression of IL-1α and IL-10 in the colon of formula-fed compared to colostrum-fed piglets. Intestinal microbiome analysis of piglets with D-NEC demonstrated lower microbial diversity and increased Gammaproteobacteria and Enterobacteriaceae.ConclusionsWe have developed a clinical sickness score and a new multifactorial D-NEC scoring system to accurately evaluate an enteral feed-only piglet model of NEC. Piglets with D-NEC had microbiome changes consistent with those seen in preterm infants with NEC. This model can be used to test future novel therapies to treat and prevent this devastating disease.
Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer
Authors: Kumari Pratima , Debta Priyanka , Dixit Anshuman 
Published: April 2023

Graphical Abstract(A)A representative diagram of changes occurring in buccal mucosa due to exposure to various carcinogenic factors. The red arrow shows the direction of changes associated with the progression of oral cancer.(B)The circular map shows the chromosomes involve in genetic alternation.
Impact of ambiguity resolution on phase center offsets and hardware delay estimation for BDS-3 inter-satellite links
Authors: Li Zongnan , Xiao Wei , Fan Lei , Lu Zukun , Wang Feixue 
Published: April 2023

The Chinese BeiDou navigation satellite system (BDS) has already completed its three phases and developed into a global navigation satellite system for open positioning, navigation, and timing services. The BDS-3 satellites feature the inter-satellite link (ISL). The ISL observation-related error model and ambiguity resolution for L-band observation are the crucial factors in precise data processing. In this study, we present for the first time the impact of ambiguity resolution on phase center offsets (PCOs) and hardware delay estimation of BDS-3 inter-satellite links. Two weeks’ L-band observations from 99 globally distributed ground stations and Ka-band ISL observations are collected for experimental validation and analysis. First, network solutions with and without ISL observations are conducted to investigate the role of ISL observation in ambiguity resolution. Afterward, ISL observation-related errors, mainly PCOs and hardware delays, are estimated by processing L-band with ISL observations with and without ambiguity resolution to analyze the impact of ambiguity resolution on these two factors. Finally, orbit accuracy in the network solution is assessed to further validate the effectiveness of the estimated PCOs and hardware delays in our experiment. The result indicates that introducing the ISL can slightly improve the fixing rate compared to only L-band observations from 83.7% to 84.3%. Furthermore, ambiguity resolution has a positive influence on the stability of estimated PCOs and hardware delays in turn, although the root mean square (RMS) values basically remain unchanged. The standard deviation (STD) of the x-offset is reduced from 0.021 m to 0.012 m, a significant improvement of about 43%, and 0.022 m–0.016 m, with an improvement of about 27%, for the y-offset. There is a slight improvement of about 8% for z-offset. Similarly, around 10% improvement in the STD for hardware delays can be achieved while the RMS values almost stay the same except for C40. Orbit determination from network solutions shows high accuracy compared to the public products for the satellite with good geometry configuration, which further validates our estimates for ISL PCOs and hardware delays.
P3/P3N-PIPO of PVY interacting with BI-1 inhibits the degradation of NIb by ATG6 to facilitate virus replication in N. benthamiana
Authors: Qing Zhen , Ahmad Shakeel , Chen Yuemeng , Liang Qingmin , Zhang Lijuan , Chen Baoshan , Wen Ronghui 
Published: April 2023

IntroductionAutophagy not only plays an antiviral role but also can be utilized by viruses to facilitate virus infection. However, the underlying mechanism of potato virus Y (PVY) infection against plant autophagy remains unclear. BI-1, localizing to the endoplasmic reticulum (ER), is a multifunctional protein and may affect the virus infection.MethodsIn this study, Y2H, BiFC, qRT-PCR, RNA-Seq, WB and so on were used for research.ResultsP3 and P3N-PIPO of PVY can interact with the Bax inhibitor 1 (BI-1) of N. benthamiana. However, BI-1 knockout mutant showed better growth and development ability. In addition, when the BI-1 gene was knocked out or knocked down in N. benthamiana, the PVY-infected mutant showed milder symptoms and lower virus accumulation. Analysis of transcriptome data showed that the deletion of NbBI-1 weakened the gene expression regulation induced by PVY infection and NbBI-1 may reduce the mRNA level of NbATG6 by regulated IRE1-dependent decay (RIDD) in PVY-infected N. benthamiana. The expression level of the ATG6 gene of PVY-infected WT was significantly down-regulated, relative to the PVY-infected mutant. Further results showed that ATG6 of N. benthamiana can degrade NIb, the RNA-dependent RNA polymerase (RdRp) of PVY. NbATG6 has a higher mRNA level in PVY-infected BI-1 knockout mutants than in PVY-infected WT.ConclussionThe interaction of P3 and/or P3N-PIPO of PVY with BI-1 decrease the expression of the ATG6 gene might be mediated by RIDD, which inhibits the degradation of viral NIb and enhances viral replication.
Investigating the modulation of stimulus types on language switching costs: Do semantic and repetition priming effect matter?
Authors: Shen Qinfang , Chen Yixin 
Published: April 2023

IntroductionIn the present study, I investigated the influence of stimulus types on bilingual control in the language switching process. The commonly employed stimuli in language switching studies – Arabic digits and objects – were compared to further investigate the way in which inhibitory control could be modulated by semantic and repetition priming effects. The digit stimuli have two unique characteristics in the language switching paradigm, for example, they are present repeatedly and are semantically related to each other, compared with pictural stimuli. Thus, these unique characteristics might influence the operation of inhibitory control in bilingual language production, modulating the size and asymmetry of switching costs.MethodsTwo picture control sets were set up to match those characteristics: (1) a semantic control set, in which picture stimuli belong to the same category group, such as, animals, occupations or transportation and specific semantic categories were presented in a blocked condition; and (2) a repeated control set, in which nine different picture stimuli were repeatedly presented like the Arabic digits from 1 to 9.ResultsWhen comparing the digit condition and the standard picture condition, analyses of naming latencies and accuracy rates revealed that switching costs were reliably smaller for digit naming than for picture naming and the L1 elicited more switching costs for picture naming than for digit naming. On the other hand, when comparing the digit condition and the two picture control sets, it was found that the magnitude of switching costs became identical and the asymmetry in switching costs became much smaller between the two languages.
The effects of shift-work schedules on the sleep, health, safety, and quality of life of police employees during the COVID-19 pandemic
Authors: James Lois , James Stephen , Atherley Loren 
Published: April 2023

IntroductionThe negative health and safety consequences of police fatigue are increasingly recognized as a critical problem. This study’s objective was to measure the effects of different shift schedules on police employee health, safety, and quality of life.MethodsA cross sectional research design surveyed employees (N = 319) from a large, U.S. west coast municipal police service during the fall of 2020. The survey was made up of a battery of validated instruments designed to assess dimensions of health and wellness (e.g., sleep, health, safety, and quality of life).ResultsWe found 77.4% of police employees had poor sleep quality, 25.7% had excessive daytime sleepiness, 50.2% had PTSD symptoms, 51.9% had depressive symptoms, and 40.8% had anxiety symptoms. Working night shifts significantly decreased sleep quality and increased excessive sleepiness. Furthermore, employees working night shifts were significantly more likely to report falling asleep at the wheel while driving home than employees working other shifts.DiscussionOur findings have implications for interventions designed to promote police employee sleep health, quality of life, and worker safety. We urge researchers and practitioners alike to target night shift workers, to help mitigate these risks.
Development and validation of a prediction nomogram for non-suicidal self-injury in female patients with mood disorder
Authors: Liang Sixiang , Li Dan , Liu Xinyu , Jiang Isadora , Zhang Jinhe , Liu Jun , Sha Sha 
Published: April 2023

BackgroundNon-suicidal self-injury (NSSI) is a highly prevalent behavioral problem among people with mental disorders that can result in numerous adverse outcomes. The present study aimed to systematically analyze the risk factors associated with NSSI to investigate a predictive model for female patients with mood disorders.MethodsA cross-sectional survey among 396 female patients was analyzed. All participants met the mood disorder diagnostic groups (F30–F39) based on the Diseases and Related Health Problems 10th Revision (ICD-10). The Chi-Squared Test,t-test, and the Wilcoxon Rank-Sum Test were used to assess the differences of demographic information and clinical characteristics between the two groups. Logistic LASSO Regression Analyses was then used to identify the risk factors of NSSI. A nomogram was further used to construct a prediction model.ResultsAfter LASSO regression selection, 6 variables remained significant predictors of NSSI. Psychotic symptom at first-episode (β = 0.59) and social dysfunction (β = 1.06) increased the risk of NSSI. Meanwhile, stable marital status (β = −0.48), later age of onset (β = −0.01), no depression at onset (β = −1.13), and timely hospitalizations (β = −0.10) can decrease the risk of NSSI. The C-index of the nomogram was 0.73 in the internal bootstrap validation sets, indicated that the nomogram had a good consistency.ConclusionOur findings suggest that the demographic information and clinical characteristics of NSSI can be used in a nomogram to predict the risk of NSSI in Chinese female patients with mood disorders.
Levels and trends of maternal death in Baoan district, Shenzhen, China, 1999–2022
Authors: Wang Wei , Zhu Yuanfang , Cheng Yuli , Chen Xu , Luo Yali 
Published: April 2023

BackgroundChina had achieved impressive success in improving maternal health, while the progress of reducing maternal mortality ratio (MMR) varied across regions. Some studies had reported maternal mortality from national or provincial perspective, but researches of the MMR on long-term period at the city or county level rare been reported. Shenzhen has experienced significant socioeconomic and health changes, reflecting the typical development of China's coastal city. This study mainly introduced the levels and trends of maternal death in Baoan district, Shenzhen from 1999 to 2022.MethodsMaternal mortality data were extracted from registration forms and the Shenzhen Maternal and Child Health Management System. Linear-by-Linear Association tests were used to evaluate the trends of MMR among different groups. The study periods were divided into three stages by 8-year interval and χ2 test or Fisher's test was used to test the difference in maternal deaths of different periods.ResultsDuring 1999–2022, a total of 137 maternal deaths occurred in Baoan, the overall MMR was 15.91 per 100,000 live births, declined by 89.31% with an annualized rate of 9.26%. The MMR declined by 68.15% in migrant population, with an annualized rate of 5.07%, faster than that in permanent population (48.73%, 2.86%). The MMR due to direct and indirect obstetric causes shown a downward trend (P&lt;0.001) and the gap between them narrowed to 14.29% during 2015–2022. The major causes of maternal deaths were obstetric hemorrhage (4.41 per 100,000 live births), amniotic fluid embolism (3.37 per 100,000 live births), medical complications (2.44 per 100,000 live births) and pregnancy-induced hypertension (1.97 per 100,000 live births), the MMR due to the above causes all shown decreasing trends (P &lt; 0.01), pregnancy-induced hypertension became the leading cause of deaths during 2015–2022. The constituent ratio of maternal deaths with advanced age significantly increased by 57.78% in 2015–2022 compared with in 1999–2006.ConclusionsBaoan district had made encouraging progress in improving maternal survival, especially in migrant population. To further reduce the MMR, strengthening professional training to improve the capacity of obstetricians and physicians, increasing the awareness and ability of self-help health care among elderly pregnant women were in urgent need.
Prevalence and influencing factors of chronic pain in middle-aged and older adults in China: results of a nationally representative survey
Authors: Ai Zhonghua , Tang Churou , Peng Puxian , Wen Xuan , Tang Songyuan 
Published: April 2023

BackgroundWith China's rapidly aging population, chronic pain has become a major public health issue. This article aims at determining associations between chronic pain and multiple factors, including demographic characteristics, health status, and health service utilization of middle-aged and older adults in China.MethodsWe selected all the 19,829 respondents who were over 45 years old from the China Health and Aging Tracking Survey 2018 (CHARLS) as our study population. The key information in terms of the body pain, demographic characteristics, health status, behaviors and health services use was extracted and analyzed. Logistic regression model was used to determine the influencing factors of chronic pain.ResultsAnalysis revealed that 60.02% (9,257) of the data from this survey reported physical pain, with pain sites concentrated at the head (40.9%), lower back (62.2%) and knees (47.2%). Pain was positively associated with influencing factors for pain: being a female (OR = 2.10, 95% CI 1.90–2.33, p &lt; 0.001), living in a western region (OR = 1.28, 95% CI 1.16–1.41, p &lt; 0.001), living in a rural area (OR = 1.14, 95% CI 1.06–1.23, p &lt; 0.001), smoked (OR = 1.26, 95% CI 1.14–1.38, p &lt; 0.001), drank alcohol (OR = 1.16, 95% CI 1.06–1.26, p = 0.001), and had poor self-rated health (OR = 6.84, 95% CI 5.41–8.65, p &lt; 0.001), had hearing problems (OR = 1.23, 95% CI 1.11–3.37, p &lt; 0.001), were depressed (OR = 1.56, 95% CI 1.03–1.29, p &lt; 0.001), had arthritis (OR = 2.21, 95% CI 2.02–2.41, p &lt; 0.001), stomach disorders (OR = 1.69, 95% CI 1.55–1.85, p &lt; 0.001), visited a Western medicine hospital (OR = 1.28, 95% CI 1.10–1.50, p = 0.002), and visits to other medical institutions (OR = 1.42, 95%CI 1.22–1.64, p &lt; 0.001). On the other side, as a protective factor for pain, having nighttime sleep ≥7 h (OR = 0.74, 95%CI 0.68–0.80, p &lt; 0.001) was negatively associated with pain.ConclusionPhysical pain affects many older adults. Women, regional, rural residents, smokers, alcohol drinkers, people with poor self-rated health, those having &lt;7 h of sleep at night, those with hearing problems, depression, arthritis, stomach disorders, and people who visits Western hospitals or other medical institutions are at greater risk for pain and deserve the attention of health care providers and policy makers to focus on pain prevention and management in middle-aged and older adults. Future research studies should also focus on the impact of health literacy on pain prevention and management outcomes.
Behind the flexibility: insufficient occupational injury protection of gig workers in China
Authors: Ran Xiaoxing , Zhao Ying 
Published: April 2023

ObjectiveOccupational injury protection is essential to safeguard the basic rights of workers. This article focuses on a group of gig workers who have emerged on a large scale in recent years in China and aims to explore their status of occupational injury protection.MethodsBased on the theory of technology-institution innovation interaction, we adopted the institution analysis to assess the work-related injury protection of gig workers. The comparative study was used to evaluate three cases of occupational injury protection in China for gig workers.ResultsInstitutional innovation failed to respond to technological innovation and provided insufficient occupational injury protection for gig workers. The work-related injury insurance was inaccessible to gig workers due to they were not treated as employees in China. The work-related injury insurance was not available to gig workers. Although some practices were explored, shortcomings remain.ConclusionsBehind the flexibility of gig work is insufficient occupational injury protection. According to the theory of technology-institution innovation interaction, we believe the reform of work-related injury insurance is increasingly essential for improving the situation of gig workers. This research contributes to expanding understanding of gig workers' situation and may offer a reference to other countries on protecting gig workers against occupational injuries.
How do parents access, appraise, and apply health information on early childhood allergy prevention? A focus group and interview study
Authors: Lander Jonas , Bitzer Eva Maria , von Sommoggy Julia , Pawellek Maja , Altawil Hala , John Cosima , Apfelbacher Christian , Dierks Marie-Luise 
Published: April 2023

BackgroundWhen parents want to make health-related decisions for their child, they need to be able to handle health information from a potentially endless range of sources. Early childhood allergy prevention (ECAP) is a good example: recommendations have shifted from allergen avoidance to early introduction of allergenic foods. We investigated how parents of children under 3 years old access, appraise and apply health information about ECAP, and their respective needs and preferences.MethodsWe conducted 23 focus groups and 24 interviews with 114 parents of children with varied risk for allergies. The recruitment strategy and a topic guide were co-designed with the target group and professionals from public health, education, and medicine. Data were mostly collected via video calls, recorded and then transcribed verbatim. Content analysis according to Kuckartz was performed using MAXQDA and findings are presented as a descriptive overview.ResultsParents most frequently referred to family members, friends, and other parents as sources of ECAP information, as well as healthcare professionals (HCPs), particularly pediatricians. Parents said that they exchanged experiences and practices with their peers, while relying on HCPs for guidance on decision-making. When searching for information online, they infrequently recalled the sources used and were rarely aware of providers of “good” health information. While parents often reported trying to identify the authors of information to appraise its reliability, they said they did not undertake more comprehensive information quality checks. The choice and presentation of ECAP information was frequently criticized by all parent groups; in particular, parents of at-risk children or with a manifested allergy were often dissatisfied with HCP consultations, and hence did not straightforwardly apply advice. Though many trusted their HCPs, parents often reported taking preventive measures based on their own intuition.ConclusionOne suggestion to react upon the many criticisms expressed by parents regarding who and how provides ECAP information is to integrate central ECAP recommendations into regular child care counseling by HCPs—provided that feasible ways for doing so are identified. This would assist disease prevention, as parents without specific concerns are often unaware of the ECAP dimension of issues such as nutrition.
Trends in health behaviors and mental health among Korean adolescents in Korea over 5 years, 2017–2021: focusing on the comparisons before and during the COVID-19 pandemic
Authors: Lee Mi-Sun , Kim Dong Jun , Lee Hooyeon 
Published: April 2023

ObjectivesWe investigated recent trends in health behaviors and mental health conditions among Korean adolescents from 2017 to 2021 and compared the changes before and during the coronavirus disease 2019 (COVID-19) pandemic.MethodsData analysis was conducted on 289,415 adolescents participating in the Korea Youth Risk Behavior Web-Based Survey, an annual cross-sectional study from 2017 to 2021. All analysis was conducted using sex stratification, and the annual percentage change (APC) was calculated.ResultsAlcohol consumption and smoking decreased in the first year of the COVID-19 pandemic compared with before, except for girls from the low-income level. The prevalence of inadequate physical activity for both boys and girls increased in 2020 compared with the pre-COVID-19 period and decreased again by 2021. The prevalence of obesity in both sexes increased regardless of the period (boys, APC = 8.2%, 95% confidence intervals (CI), 6.4–10.1; girls, APC = 3.3%, 95% CI, 1.8–4.8). The prevalence of stress, depression, and suicidal ideation, plans, and attempts for both sexes decreased in 2020 compared to the pre-COVID-19 period. By 2021, this prevalence had returned to a level similar to before the pandemic. No significant APC changes were observed in the prevalence of mental health.ConclusionsThese findings demonstrate the trends and APCs in health behaviors and mental health conditions among Korean adolescents over the last 5 years. We must pay attention to the heterogeneous and multifaceted features of the COVID-19 pandemic.