bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation Between Quantitative Background Suppression on EEG and Serum NSE in Patients With Hypoxic-ischemic Encephalopathy
Authors: Lee Dong Ah , Sohn Gyeong Mo , Kim Byung Joon , Yoo Byung Chul , Lee Jae Hyeok , Choi Hyun Ju , Kim Sung Eun 
Published: September 2023

Purpose:
We evaluated the correlation between quantitative background activities on electroencephalography (EEG) and serum neuron specific enolase (NSE) in patients with hypoxic-ischemic encephalopathy as well as a diagnostic value of prognostication.

Methods:
This retrospective cohort study enrolled patients with return of spontaneous circulation after cardiac arrest from March 2010 to March 2020. The inclusion criteria were (1) older than the age of 16 years and (2) patients who had both EEG and NSE. The median time for EEG and NSE were 3 days (interquartile range 2–5 days) and 3 days (interquartile range 2–4 days), respectively. The quantification of background activity was conducted with the suppression ratio (SR). We used a machine learning (eXtreme Gradient Boosting algorithm) to evaluate whether the SR could improve the accuracy of prognostication.

Results:
We enrolled 151 patients. The receiver operating characteristic analysis revealed a cut-off value of serum NSE and the SR for poor outcome, serum NSE (>31.9 μg/L, area under curve [AUC] = 0.88), and the SR (>21.5%, AUC = 0.75 in the right hemisphere, >34.4%, AUC = 0.76 in the left hemisphere). There was a significant positive correlation between the severity of SR and the level of NSE (ρ = 0.57, p < 0.0001 for the right hemisphere, ρ = 0.58, p < 0.0001 for the left hemisphere). The SR showed an excellent diagnostic value for predicting poor outcome (93% specificity, 60% sensitivity in the right hemisphere and 93% specificity, 58% sensitivity in the left hemisphere). With machine learning analysis, there was an increment in distinguishing the neurological outcome by adding SR on clinical factors.

Conclusions:
The SR showed a positive correlation with the level of serum NSE. The diagnostic value of the SR for predicting poor outcome was excellent, suggesting that it can be a possible biomarker for neuroprognostication in patients with hypoxic-ischemic encephalopathy.
Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders
Authors: Li Wenqianglong , Zhou Hang , Thygesen Johan H. , Heydtmann Mathis , Smith Iain , Degenhardt Franziska , Nöthen Markus , Morgan Marsha Y. , Kranzler Henry R. , Gelernter Joel , Bass Nicholas , McQuillin Andrew 
Published: September 2023

Introduction
While progress has been made in determining the genetic basis of antisocial behaviour, little progress has been made for antisocial personality disorder (ASPD), a condition that often co-occurs with other psychiatric conditions including substance use disorders, attention deficit hyperactivity disorder (ADHD), and anxiety disorders. This study aims to improve the understanding of the genetic risk for ASPD and its relationship with other disorders and traits.

Methods
We conducted a genome-wide association study (GWAS) of the number of ASPD diagnostic criteria data from 3217 alcohol-dependent participants recruited in the UK (UCL, N = 644) and the USA (Yale-Penn, N = 2573).

Results
We identified rs9806493, a chromosome 15 variant, that showed a genome-wide significant association (Z-score = −5.501, P = 3.77 × 10−8) with ASPD criteria. rs9806493 is an eQTL for SLCO3A1 (Solute Carrier Organic Anion Transporter Family Member 3A1), a ubiquitously expressed gene with strong expression in brain regions that include the anterior cingulate and frontal cortices. Polygenic risk score analysis identified positive correlations between ASPD and smoking, ADHD, depression traits, and posttraumatic stress disorder. Negative correlations were observed between ASPD PRS and alcohol intake frequency, reproductive traits, and level of educational attainment.

Conclusion
This study provides evidence for an association between ASPD risk and SLCO3A1 and provides insight into the genetic architecture and pleiotropic associations of ASPD.
Investigating high-speed liquid impingement with full-field measurements
Authors: Burson-Thomas C. B. , Harvey T. J. , Fletcher L. , Wellman R. , Pierron F. , Wood R. J. K. 
Published: September 2023

Repeated high-speed liquid impingement on solid surfaces results in erosion that can have undesirable consequences. In recent years, the capacity of model predictions has exceeded the experimental measurements of an impingement; this work closes the gap. Using the grid method, tens of thousands of individual measurements of surface displacement were taken of the response of a polymethylmethacrylate test specimen to the impingement of a high-speed (

233

m

s

−
1

) curved-fronted water jet. The full-field measurements were taken at a rate of 5 MHz and interpreted using two models based on differing sets of assumptions. The results support the current qualitative description of a high-speed impingement. However, the widespread assumption of a rigid solid surface in existing analysis and modelling was found to be inaccurate: only the model that recognized the effect of the compliance of the solid surface was successful in predicting the measured temporal and spatial variation in displacement and acceleration. This model predicted that the energy absorbed by the solid surface was less than 0.3% of the total kinetic energy of the equivalent droplet impingement.
Expanding the DNA editing toolbox: novel lambda integrase variants targeting microalgal and human genome sequences
Authors: Wei Siau Jia , Siddiqui Asim Azhar , Yi Lau Sze , Kannan inivasaraghavan , Peter Sabrina , Yingying Zeng , Verma Chandra , Droge Peter , Ghadessy John F. 
Published: September 2023

AbstractRecombinase enzymes are extremely efficient at integrating very large DNA fragments into target genomes. However, intrinsic sequence specificities curtail their use to DNA sequences with sufficient homology to endogenous target motifs. Extensive engineering is therefore required to broaden applicability and robustness. Here, we describe the directed evolution of novel lambda integrase variants capable of editing exogenous target sequences identified in the diatomPhaeodactylum tricornutumand the algaeNannochloropsis oceanica. These microorganisms hold great promise as conduits for green biomanufacturing and carbon sequestration. The evolved enzyme variants show >1000-fold switch in specificity towards the non-natural target sites when assayedin vitro. A single-copy target motif in the human genome with homology to theNannochloropsis oceanicasite can also be efficiently targeted using an engineered integrase, bothin vitroand in human cells. The developed integrase variants represent useful additions to the DNA editing toolbox, with particular application for targeted genomic insertion of large DNA cargos.
Genome Report: Chromosome-scale Genome Assembly of the West Indian fruit flyAnastrepha obliqua(Diptera: Tephritidae)
Authors: Sim Sheina B. , Congrains Carlos , Velasco-Cuervo Sandra M. , Corpuz Renee L. , Kauwe Angela N. , Scheffler Brian , Geib Scott M. 
Published: September 2023

AbstractThe West Indian fruit fly,Anastrepha obliqua, is a major pest of mango in Central and South America and attacks more than 60 species of host fruits. To support current genetic and genomic research onA. obliqua, we sequenced the genome using high-fidelity (HiFi) long-read sequencing. This resulted in a highly contiguous contig assembly with 90% of the genome in 10 contigs. The contig assembly was placed in a chromosomal context using synteny with a closely related species,A. ludens, as both are members of theA. fraterculusgroup. The resulting assembly represents the five autosomes and the X chromosome which represents 95.9% of the genome, and 199 unplaced contigs representing the remaining 4.1%. Orthology analysis across the structural annotation sets of high quality tephritid genomes demonstrates the gene annotations are robust, and identified genes unique toAnastrephaspecies that may help define their pestiferous nature that can be used as a starting point for comparative genomics. This genome assembly represents the first of this species and will serve as a foundation for future genetic and genomic research in support of its management as an agricultural pest.
Self-identification by Sexual and Gender Minorities as a Crucial Aspect of Inclusion in a Study of Adverse Childhood Experiences in Haiti
Authors: Heger Joseph , Paul Phycien , Jean-Baptiste Caleb , Odans Elmondo , Salinas-Miranda Abraham A. , Lynch Erin , Stevens Emily , Rahill Guitele J. , Joshi Manisha 
Published: September 2023

AbstractResearch studies are inevitably affected by contextual norms, local ideologies, social mores, and self-identification in addition to extant policies and laws. Self-identification is often emotionally laden and can be constrained by fear of reprisal if one’s self-identification departs from acceptable and affirmed norms. Such complexities can hinder measurement efforts and results from established measures can fail to yield accurate and thus useful data. Studies of Adverse Childhood Experiences (ACEs) are important but understudied in Haiti. We investigated ACEs in urban Haiti using the ACE International Questionnaire (ACE-IQ). Descriptive statistics revealed: (1) A relationship between participants’ self-identification and sex recorded as observed by interviewers, and (2) Prevalence of ACEs by self-reported identity. Roughly half participants self-identified as ’Woman’ (56%; n = 380), 39% as ’Man’ (n = 265), 2% as ’Homosexual’ (n = 13), and 2% as ’Lesbian’ (n =14). Contradictions emerged between participant self-identification and interviewers’ record of sex: 98% self-identified women were observed/recorded as ’Female’, one was observed/recorded as ’Male’, and there was no record for five. Similarly, 95% self-identified men were observed/recorded as ’Male’, six as ’Female’, two as ’Other’, and there was no record for five. Although Sexual and Gender Minorities (SGM) constituted a small subsample (n = 27), their responses underscored misclassification and disproportionate burdens of physical, emotional, and sexual abuse, family dysfunction, and other forms of interpersonal violence. Conducting ACE-IQ studies in Haiti that provide inclusive categories of self-identification may more equitably capture unique ACEs of all Haitians.
Evaluation of computer vision syndrome in the sample of students from the College of Medicine/University of Kerbala result of online learning with the isolation of COVID-19
Authors: AbuRagheif Mahdy H 
Published: September 2023

AbstractBackgroundA complex of vision problems related to stress the vision is experienced during the use of the computer or any digital device. Many of the visual problems that users report is just transient and go away after they stop using computers or other digital devices. Even after stopping their computer job, some people may still have diminished visual abilities, such as blurry distance vision.Subject and MethodThis is a cross-sectional study conducted at the University of Kerbala College of Medicine, which was completed between November 2021 and January 2022, to students of the College of Medicine given student questionnaires about the effects of long-time use of computers, laptops, and mobile phones.ResultThe cross-section studies with questionnaires to 460 students of the College of the Medicine/ University of Karbala, included these studies, we drew lines for the criteria to identify a computer vision syndrome from these associated ocular and extraocular symptoms and recorded a high prevalence of the Computer Vision syndrome reached 91.6%.
The time course of injury-risk after return-to-play in professional football
Authors: Zhang Guangze , Brink Michel , aus der Fünten Karen , Trolß Tobias , Willeit Peter , Meyer Tim , Lemmink Koen , Hecksteden Anne 
Published: September 2023

AbstractBackgroundInjury risk in professional football is increased in the weeks following return-to-play (RTP). However, the time course of injury risk after RTP (the hazard curve) as well as its influencing factors are largely unknown. This knowledge gap, which is arguably due to the volatility of instantaneous risk when calculated for short time intervals, impedes on informed RTP decision-making and post-RTP player management.ObjectivesTo characterize the hazard curve for non-contact, time-loss injuries after RTP in male professional football and investigate the influence of the severity of the index injury and playing position.MethodsMedia-based injury records from the first German football league were collected over four seasons as previously published. Time-to-event analysis was employed for non-contact, time-loss injury after RTP. The Kaplan-Meier survival function was used to calculate the cumulative hazard function, from which the continuous hazard function was retrieved by derivation.Results1623 observed and 1520 censored events from 646 players were analyzed. The overall shape of the hazard curve was compatible with an exponential decline of injury risk, from an approximately two-fold level shortly after RTP towards baseline, with a half-time of about four weeks. Interestingly, the peak of the hazard curve was slightly delayed for moderate and more clearly for severe index injuries.ConclusionsThe time course of injury risk after RTP (the hazard curve) can be characterized based on the Kaplan-Meier model. The shape of the hazard curve and its influencing factors are of practical as well as methodological relevance and warrant further investigation.Summary boxWhat is already known on this topic -As football players return to play after an injury, the risk of incurring a subsequent injury is high. With (event-free) time, this elevated risk returns to baseline. However, the shape of the risk-trajectory over time as well as its influencing factors are unknown.What this study adds -This study characterizes the time course of injury risk after RTP by providing a continuous hazard curve. Moreover, differences in risk trajectories across severities of index injury and playing positions were investigated.How this study might affect research, practice or policy -An evidence-informed estimate of the excess injury risk still remaining at a certain time-point after RTP is of obvious use for RTP decision making and post-RTP player management. Moreover, the continuous hazard curves enable informed specification of follow-up period in epidemiological studies and verification of the proportional hazard assumption in data analysis.
Longitudinal Trajectories of Symptom Change During Antidepressant Treatment Among Managed Care Patients with Co-Occurring Depression and Anxiety
Authors: Cukor Judith , Xu Zhenxing , Vekaria Veer , Wang Fei , Olfson Mark , Banerjee Samprit , Simon Gregory , Alexopoulos George , Pathak Jyotishman 
Published: September 2023

ABSTRACTDepression and anxiety are highly correlated, yet little is known about the course of each condition when presenting concurrently. This study aimed to identify longitudinal patterns and changes in depression and anxiety symptoms during antidepressant treatment, and evaluate clinical factors associated with each response pattern. Self-report Patient Health Questionnaire-9 (PHQ-9) and General Anxiety Disorder-7 (GAD-7) scores were used to track the courses of depression and anxiety respectively over a three-month window, and group-based trajectory modeling was used to derive subgroups of patients who have similar response patterns. Multinomial regression was used to associate various clinical variables with trajectory subgroup membership. Of the 577 included adults, 373 (64.6%) were women, and the mean age was 39.3 (SD: 12.9) years. Six depression and six anxiety trajectory subgroups were computationally derived; three depression subgroups demonstrated symptom improvement, and three exhibited nonresponse. Similar patterns were observed in the six anxiety subgroups. Factors associated with treatment nonresponse included higher pretreatment depression and anxiety severity and poorer sleep quality, while better overall health and younger age were associated with higher rates of remission. Synchronous and asynchronous paths to improvement were also observed between depression and anxiety. High baseline depression or anxiety severity alone may be an insufficient predictor of treatment nonresponse. These findings have the potential to motivate clinical strategies aimed at treating depression and anxiety simultaneously.
Enhancing HIV testing yield in southern Mozambique: the effect of a Ministry of Health training module in targeted provider-initiated testing and counselling
Authors: Saura-Lázaro Anna , Fernández-Luis Sheila , Nhampossa Tacilta , Fuente-Soro Laura , López-Varela Elisa , Bernardo Edson , Augusto Orvalho , Sánchez Teresa , Vaz Paula , Wei Stanley C. , Kerndt Peter , Honwana Nely , Young Peter , Amane Guita , Boene Fernando , Naniche Denise 
Published: September 2023

AbstractBackgroundIn Mozambique, targeted provider-initiated HIV testing and counselling (PITC) is recommended to increase HIV testing yield where universal PITC is not feasible. However, its effectiveness depends on healthcare providers’ training. We evaluated the effect of a Ministry of Health training module in targeted PITC on the HIV testing yield.MethodsWe conducted a single-group pre-post study between November 2018 and November 2019 in the triage and emergency departments of four healthcare facilities in Manhiça District. It consisted of two two-month phases split by a one-week targeted PITC training module (“observation phases”). During both phases, providers reported their recommendation to test or not for individuals ≥15 years, and study HIV counsellors performed universal testing. We calculated HIV testing yield of targeted PITC as the proportion of HIV-positive individuals among those provider-recommended and tested. We compared pre- and post-training yields using two-proportion z-test. Additionally, we extracted aggregated health information system data over the four months preceding and following the observation phases to compare yield in real-world conditions (“routine phases”). We used logistic regression to identify predictors of HIV test positivity.ResultsAmong 7,102 participants in the pre- and post-training observation phases (58.5% and 41.5% respectively), 68% were women, and 96% were recruited at triage. While HIV testing yield between pre- and post-training observation phases was similar, we observed an increase in yield in the post-training routine phase for women in triage (Yield ratio=1.54; 95%CI: 1.11-2.14). Age (25-49 years) (OR=2.43; 95%CI: 1.37-4.33), working in industry/mining (OR=4.94; 95%CI: 2.17-11.23), unawareness of partner’s HIV status (OR=2.50; 95%CI: 1.91-3.27), and visiting a healer (OR=1.74; 95%CI: 1.03-2.93) were factors associated with HIV test positivity. Including these factors in the targeted PITC algorithm could increase new HIV diagnoses by 2.6%. Furthermore, testing individuals with ≥1 HIV risk factor/symptom and a negative HIV test within the past three months revealed an additional 3.5% of undiagnosed PLHIV.ConclusionsWe found over 50% increase in the HIV testing yield of targeted PITC among women in the four months following the training and observation phases. Including additional sociodemographic and risk factors in the targeted PITC algorithm could help identify undiagnosed PLHIV.
Perivascular space enlargement accelerates with hypertension, white matter hyperintensities, chronic inflammation, and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Authors: Menze Inga , Bernal Jose , Kaya Pinar , Aki Çağla , Pfister Malte , Geisendörfer Jonas , Yakupov Renat , Heneka Michael T. , Brosseron Frederic , Schmid Matthias C. , Glanz Wenzel , Incesoy Enise I. , Butryn Michaela , Rostamzadeh Ayda , Meiberth Dix , Peters Oliver , Preis Lukas , Lammerding Dominik , Gref Daria , Priller Josef , Spruth Eike J. , Altenstein Slawek , Lohse Andrea , Hetzer Stefan , Schneider Anja , Fliessbach Klaus , Kimmich Okka , Vogt Ina R. , Wiltfang Jens , Bartels Claudia , Schott Björn H. , Hansen Niels , Dechent Peter , Buerger Katharina , Janowitz Daniel , Perneczky Robert , Rauchmann Boris-Stephan , Teipel Stefan , Kilimann Ingo , Goerss Doreen , Laske Christoph , Munk Matthias H. , Sanzenbacher Carolin , Hinderer Petra , Scheffler Klaus , Spottke Annika , Roy-Kluth Nina , Lüsebrink Falk , Neumann Katja , Jessen Frank , Schreiber Stefanie , Düzel Emrah , Ziegler Gabriel 
Published: September 2023

AbstractBackgroundPerivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and its exacerbators require further investigation.MethodsWe studied centrum semiovale (CSO) and basal ganglia (BG) PVS computationally over three to four annual visits in 557 participants of the DZNE multicentre DELCODE cohort. We tested volumetric changes of PVS in relation to ageing, sex, years of education, hypertension, AD diagnosis, and cerebrospinal-fluid-derived Amyloid and Tau positivity and interleukin 6 (IL-6).ResultsPVS volumes increased over time. PVS enlargement was associated with baseline white matter hyperintensities. BG-PVS enlargement was related to age and was faster with hypertension. CSO-PVS volumes increased faster with Amyloid and Tau positivity. Higher CSF IL-6 levels predicted PVS volume expansion in both regions and were associated with accelerated PVS enlargement in individuals with Amyloid and Tau positivity.ConclusionOur work supports the region-specific involvement of white matter hyperintensities, neurotoxic waste accumulation, and inflammation in PVS enlargement.
Development and Validation of the Alimetry® Gut-Brain Wellbeing Survey: A novel patient-reported mental health scale for patients with chronic gastroduodenal symptoms
Authors: Law Mikaela , Pickering Isabella , Humphrey Gayl , Sebaratnam Gabrielle , Schamberg Gabriel , Simpson Katie , Varghese Chris , Du Peng , Daker Charlotte , Huang I-Hsuan , Khalsa Sahib S. , Gharibans Armen , O’Grady Greg , Andrews Christopher N. , Calder Stefan 
Published: September 2023

AbstractObjectiveThere is currently a lack of validated questionnaires designed specifically to assess mental health within patients with chronic gastroduodenal symptoms. This research describes the multi-phase process used to develop and validate a novel mental health scale for patients with chronic gastroduodenal symptoms, the Alimetry® Gut-Brain Wellbeing (AGBW) Survey.MethodsA patient-centred multi-phase process was implemented. In Phase 1, the most relevant concepts for this patient population were selected from existing mental health scales, using data from 79 patients. In Phase 2, an interdisciplinary panel of experts generated scale items. In Phase 3, the scale underwent pre-testing with gastroenterologists (n=9), health psychologists (n=3), and patients (n=12), with feedback incorporated over multiple rounds. Lastly, the psychometric properties of the scale were assessed in a sample of 311 patients via an online survey.ResultsThe AGBW Survey comprises a patient preface, 10 close-ended questions, and an optional open-ended question. This multidimensional scale assesses general mental health, alongside specific subscales relating to depression, stress, and anxiety. The subscale and total scores demonstrated high internal consistency (α= .91 for the total scale; α= .72-.86 for subscales) and good convergent, divergent, concurrent validity, and known groups validity, with large effect sizes.ConclusionsThe AGBW Survey is a brief, valid, and reliable scale for assessing mental health in patients with chronic gastroduodenal symptoms. It can be used as a tool to complement physiological tests and has the potential to guide psychological referrals, inform multidisciplinary management, and evaluate treatment outcomes.