bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATG8 delipidation is not universally critical for autophagy in plants
Authors: Zou Yong , Ohlsson Jonas A , Holla Sanjana , Sabljić Igor , Leong Jia Xuan , Ballhaus Florentine , Krebs Melanie , Schumacher Karin , Moschou Panagiotis N , Stael Simon , Üstün Suayb , Dagdas Yasin , Bozhkov Peter V , Minina Elena A 
Published: August 2023

AbstractIntracellular recycling via autophagy is governed by post-translational modifications of the autophagy-related (ATG) proteins. One notable example is ATG4-dependent delipidation of ATG8, a process that plays critical but distinct roles in autophagosome formation in yeast and mammals. Here, we aimed to elucidate the specific contribution of this process to autophagosome formation in species representative of evolutionary distant green plant lineages: unicellular green algaChlamydomonas reinhardtii, with a relatively simple set ofATGgenes, and a vascular plantArabidopsis thaliana, harboring expandedATGgene families.Remarkably, the more complex autophagy machinery ofArabidopsisrendered ATG8 delipidation entirely dispensable for the maturation of autophagosomes, autophagic flux and related stress tolerance; whereas autophagy inChlamydomonasstrictly depended on the ATG4-mediated delipidation of ATG8. Importantly, we uncovered the distinct impact of different Arabidopsis ATG8 orthologs on autophagosome formation, especially prevalent under nitrogen depletion, providing a new insight into potential drivers behind the expansion of the ATG8 family in higher plants.Our findings underscore the evolutionary diversification of the molecular mechanism governing the maturation of autophagosomes in eukaryotic lineages and highlight how this conserved pathway is tailored to diverse organisms.
Monitoring Lake Okeechobee Harmful Algal Bloom populations and dynamics with a long-duration Autonomous Surface Vehicle
Authors: Xomchuk Veronica Ruiz , Duncan Scott , McFarland Malcolm N. , Beckler Jordon S. 
Published: August 2023

AbstractThis article describes the main findings of a full year of continuous operation of a 2-meter Autonomous Sail and Solar Surface Drone, the Nav2 (Navocean Inc.), as part of a Harmful Algal Bloom (HAB) monitoring program in Lake Okeechobee. The Nav2 was equipped with a set of water quality and atmospheric sensors, that recorded high frequency measurements (¡ 1 min) and transmitted near real-time information to allow reporting through a web portal for assessment and operation responses. Major findings include detection of HABs early in the year through chlorophyll (chl-a) and phycocyanin (phyco) fluorometric measurements, as well as different spatial scales of variability in the algal patches. The 24/7 high resolution monitoring allowed detection of patch motion and discrimination between growth and motion along a transect. Furthermore, the platform can potentially fingerprint specific HAB species based on the relatively fine-scale spatial expression of the phyco to chl-a ratio, which essentially captures the bloom macrostructure (e.g. surface scums versus more uniform sub-surface waves over 0.1 - 1 km scale). Sensor outputs, when converted to concentrations based on calibrated with pure laboratory standards, did not accurately yield true chl-a or phyco values when compared to validation samples, likely due to the high turbidity of the lake. However, routine solid-state validations of fluorometric measurements proved useful for assessing consistency in optical sensors to check for sensor drift (e.g. to due biofouling), which was not significant. Overall this demonstration shows that the Nav2 can uniquely and reliably provide in situ HAB and environmental monitoring capabilities in a large, turbid, shallow lake. We envision that platform as an innovative technology for water resource managers by providing turn-key long-duration baseline environmental data (hands-off waypoint navigation), early warnings of HABs for protecting human health, and for HAB mitigation monitoring.
The fast multipole method–accelerated line integration boundary element method for 3D heat conduction analysis with heat source
Authors: Liu Biao , Wang Qiao , Feng Y.T. , Zhang Zongliang , Huang Quanshui , Tian Wenxiang , Zhou Wei 
Published: August 2023

Purpose3D steady heat conduction analysis considering heat source is conducted on the fundamental of the fast multipole method (FMM)-accelerated line integration boundary element method (LIBEM).Design/methodology/approachDue to considering the heat source, domain integral is generated in the traditional heat conduction boundary integral equation (BIE), which will counteract the well-known merit of the BEM, namely, boundary-only discretization. To avoid volume discretization, the enhanced BEM, the LIBEM with dimension reduction property is introduced to transfer the domain integral into line integrals. Besides, owing to the unsatisfactory performance of the LIBEM when it comes to large-scale structures requiring massive computation, the FMM-accelerated LIBEM (FM-LIBEM) is proposed to improve the computation efficiency further.FindingsAssuming N and M are the numbers of nodes and integral lines, respectively, the FM-LIBEM can reduce the time complexity from O(NM) to about O(N+ M), and a full discussion and verification of the advantage are done based on numerical examples under heat conduction.Originality/value(1) The LIBEM is applied to 3D heat conduction analysis with heat source. (2) The domain integrals can be transformed into boundary integrals with straight line integrals by the LIM. (3) A FM-LIBEM is proposed and can reduce the time complexity from O(NM) to O(N+ M). (4) The FM-LIBEM with high computational efficiency is exerted to solve 3D heat conduction analysis with heat source in massive computation successfully.
Work-life balance policies and organizational financial performance: a scoping review
Authors: Opatrná Zuzana , Prochazka Jakub 
Published: August 2023

PurposeWork-life balance (WLB) policies have become a popular topic in both academic literature and organizations. However, previous studies in this area have provided mixed results, and the impact of WLB policies on various indicators of organizational financial performance remains unclear. There has been no comprehensive review that synthesizes the current state of knowledge and indicates future research directions. This review addresses this gap and provides a systematic review of published papers investigating the relationship between WLB policies and organizational financial performance.Design/methodology/approachThe review follows the PRISMA-ScR guidelines for scoping reviews. An analysis of 421 relevant records in Web of Science and Scopus databases identified 22 original empirical studies that focused on the relationship between WLB policies and financial performance at the level of the organization.FindingsMost reviewed studies indicated a weak positive relationship between WLB policies and financial performance. There was the strongest support for the effectiveness of flexible working hours and job sharing, while there was mixed support for the policy of working from home. There were a higher proportion of positive results in studies conducted in Western countries compared to Asian countries, which indicates a potential moderating effect of culture. This review also describes the primary limitations of previous studies, namely, low test power and insufficient evidence about causality.Originality/valueThis review summarizes the growing body of quantitative research on the relationship between WLB policies and organizational financial performance. It presents a model that includes moderators and mediators of this relationship and indicates potentially fruitful areas for future research.
Examining women leaders’ identity conflict in a low gender egalitarian culture: a study of female corporate sector leaders in Pakistan
Authors: Bano Ayesha , Nadeem Sadia 
Published: August 2023

Purpose
This study aims to explore the factors that build positive leadership identities in women and reduce woman-leader identity conflict in societies with low gender equality. In doing so, it responds to calls to examine the role of “context” for women aspiring to leadership roles.

Design/methodology/approach
The required data were collected through semistructured interviews with 30 senior-level female leaders in the corporate sector of Pakistan and analyzed using NVivo.

Findings
Successful professional women are often facilitated by various social and organizational factors that boost their confidence and ability to view themselves positively as leaders, reducing woman-leader identity conflict. The main facilitators observed were egalitarian values practiced at home, male sponsorship in organizations and individual leadership experiences. Furthermore, the age and socio-economic status of women have also emerged as important factors contributing to the success of women leaders in Pakistani society, which is characterized by gender inequality and high power distance.

Practical implications
Organizations committed to developing women for leadership roles and attaining their gender diversity goals need to address the structural and psychological barriers that hinder women’s progress in the workplace. Moreover, men need to be engaged as allies to enable women’s advancement as organizational leaders.

Originality/value
This study highlights how culture, gender norms and significant experiences of women moderate equality lows in patriarchal societies. It aims to demonstrate that women can progress as leaders within a low gender-egalitarian culture in the presence of factors that facilitate the establishment of their identities as leaders, thus reducing identity conflict. In addition, the role that men can play in creating a supportive environment for establishing women’s leadership identities is particularly highlighted in this study.
Energy management in small and medium manufacturing firms: examining the enhancing role of top management commitment in a developing country context
Authors: Arinaitwe Alice , Bagire Vincent , Tukamuhabwa Benjamin , Sulait Tumwine 
Published: August 2023

Purpose
The purpose of this paper is to examine the relationship between top management commitment and energy management in small and medium manufacturing firms in a developing country context.

Design/methodology/approach
This study was executed through a survey of 66 manufacturing firms in Kampala, Uganda. The data collected were analysed using SPSS v.26.

Findings
The results show that top management commitment influences energy management. A further probe of its three dimensions of top management participation, top management support and top management beliefs reveals that all of them positively and significantly predict energy management in manufacturing firms.

Research limitations/implications
The current study results were obtained from manufacturing small and medium firms in Kampala, Uganda. Therefore, caution should be taken prior to generalization. Furthermore, this study only focuses on top management participation, top management support and top management beliefs as the dimensions of top management commitment. This study thus provides the foundation for future studies to test other dimensions of top management commitment, particularly in other sectors.

Originality/value
To the best of the authors’ knowledge, this is the first study to examine the contribution of top management commitment dimensions top management participation, top management support and top management beliefs to energy management in a developing country context. Although all dimensions are significant, top management beliefs contribute more to energy management.
Customer experience in pharmaceutical B2B markets: perspectives of buyers and sellers
Authors: Abraham Balaji , Sarkar Soumya , DasGupta Krishna 
Published: August 2023

Purpose
The purpose of this study is to understand customer experience (CX) in business-to-business (B2B) markets through the perspectives of buyer–seller dyads. This study aims to evaluate how customer journey, touchpoints and digital and social media (DSM) influence CX and offer avenues for sellers to align their efforts with buyers’ requirements to create and manage CX.

Design/methodology/approach
Integrating insights of practicing buyers and sellers in the pharmaceutical B2B industry, this study follows the phenomenological approach to understand their experience through their perspectives on the customer journey, touchpoints and DSM.

Findings
The findings of this study include convergence in the perspectives in journey stages, journey enablers, stakeholder involvement, touchpoint preference and DSM’s use. The study findings also include divergence in perspectives in the senior management engagement, journey enablers, selling center involvement, DSM purpose and usage of DSM platforms. These offer opportunities for sellers to align with buyer journey, touchpoints and DSM to create and manage CX.

Practical implications
Sellers in pharmaceutical B2B markets have been dependent on traditional knowledge to influence customer journey and touchpoints and the advent of DSM has enhanced the challenge. To avoid this confusion, sellers need to have clarity of customers’ expectations on the journey, touchpoints and DSM. This enables sellers to allocate their resources better to achieve the desired outcome in CX.

Originality/value
This first-of-its-kind study captured the convergence and divergence perspectives of pharmaceutical B2B buyer–seller dyads from the lens of the uncertainty reduction theory and social penetration theory. The study suggests opportunities for pharmaceutical sellers to create and manage CX.
Is internal migration a way to cope with weather extremes? Evidence from Egypt
Authors: Arouri Mohamed , Ben-Youssef Adel , Nguyen Cuong Viet 
Published: August 2023

PurposeIn this study, the authors examine the push and pull effects of extreme weather events on migration among governorates in Egypt.Design/methodology/approachTo estimate the effect of extreme weather events on internal migration, the authors use migration gravity models and data from the 1996 and 2006 Population and Housing Censuses. The authors measure weather extremes by the number of months in the past 36 months with temperatures or precipitation of a governorate below the 5th percentile and above the 95th percentile of the distribution of monthly temperatures or precipitation of the corresponding governorate during the period 1900–2006.FindingsThis study’s results suggest that high temperatures in the origin area act as a push factor. High-temperature extremes have a positive effect on out-migration. A 1% increase in the number of months with high-temperature extremes in the original governorate results in a 0.1% increase in the number of out-migrants.Practical implicationsThe study suggests that people may respond to weather extremes through migration. However, climate migrants in Egypt may encounter several significant risks that authorities must address.Originality/valueThis study is one of the first attempts to measure the push and pull effect of weather extremes on migration in Egypt.
Real‐world retention rates and effectiveness of secukinumab in psoriasis: Results from a multicenter cohort study (RAILWAY)
Authors: Tada Yayoi , Morita Akimichi , Yamanaka Keiichi , Kono Michihiro , Imafuku Shinichi , Okubo Yukari , Yamazaki Fumikazu , Kawamura Taisuke , Itakura Asako , Ohtsuki Mamitaro 
Published: August 2023

AbstractPsoriasis is a chronic, immune‐mediated inflammatory skin disease with a high negative impact on patient's quality of life. Secukinumab, the first interleukin 17A inhibitor, has been used for the systemic treatment of psoriasis, but its long‐term, real‐world retention rates in Japan have not been fully investigated. In this multicenter, noninterventional, retrospective chart review study, the retention rate of secukinumab and its effectiveness among patients with psoriasis in Japan was evaluated up to 5 years. Data of patients who received secukinumab after December 26, 2014, were collected from medical charts obtained from seven sites, all certified for biologics use by the Japanese Dermatological Association. Patient characteristics, secukinumab retention, factors affecting secukinumab retention, reason for drug discontinuation, and effectiveness data were collected. The primary end point was secukinumab retention rate at week 52. A total of 123 patients were included in the analysis. Of these, 27 patients discontinued secukinumab by week 52, yielding a 78.0% (95% confidence interval, 69.6–84.4) retention rate at week 52. For patients whose Psoriasis Area and Severity Index (PASI) score was available, mean ± standard deviation PASI at baseline and at week 52 were 9.21 ± 7.37 and 1.4 ± 2.6, respectively. During the entire study period, “insufficient response” was the most common reason for discontinuation, and “history of biologics use” was a factor significantly associated with secukinumab discontinuation (hazard ratio, 1.72; p = 0.018). This study demonstrates the real‐world retention rate and effectiveness of secukinumab in patients with psoriasis in Japan for up to 5 years and provides clinical insights into psoriasis treatment strategies.
Malnutrition screening tool use in a New Zealand hospital: Reliability and rates of malnutrition screening on admission
Authors: Diep‐Pham Huyen‐Tran , Donald Natasha , Wall Catherine L. 
Published: August 2023

AbstractAimsThis research aimed to assess the rate and reliability of routine nurse‐completed malnutrition screening and report the prevalence of malnutrition risk on admission to Christchurch Hospital.MethodsStudent dietitians administered the Malnutrition Screening Tool to patients in three speciality wards within 48 h of admission. Student dietitians' Malnutrition Screening Tool scores were compared against documented nurse‐completed Malnutrition Screening Tool scores. Data were analysed using descriptive statistics, Fisher's exact test, and Cohen's kappa tests (interrater reliability ⱪ). A p‐value <0.05 was considered statistically significant.ResultsStudent dietitians, using the Malnutrition Screening Tool, screened 360 (96%) of 377 eligible patients while nurses screened 332 (88%) patients. Student dietitians and nurses screened 119 patients (33%) and 63 patients (18%) respectively at risk of malnutrition. There was fair agreement (ⱪ = 0.311) in Malnutrition Screening Tool total scores between nurses and student dietitians. There was a significant difference in the proportion of patients screened at risk of malnutrition between nurses and student dietitians (p < 0.0001).ConclusionMalnutrition risk remains high in acute care settings. Nurses were less likely to screen patients as at risk of malnutrition than student dietitians. Regular support and training in using Malnutrition Screening Tool may help improve the rate and reliability of routine malnutrition screening.
Costovertebral and costotransverse joint involvement in spondyloarthritis
Authors: Ata Emine Büşra , Durhan Gamze , Bilgin Emre , Arıyürek Orhan Macit , Kalyoncu Umut 
Published: August 2023

AbstractObjectivesCostovertebral (CV), costotransverse (CTr), sternoclavicular (SC), and manubriosternal (MS) joints are impacted in spondyloarthritis (SpA) patients; however, clinical aspects of these involvements require additional evaluation.MethodsA total of 281 SpA patients who had undergone chest computed tomography (CT) for any reason between 2010 and 2020 were included in the study. SpA patients were divided into three groups, ankylosing spondylitis (AS), non‐radiographic axial SpA, and psoriatic arthritis. Thirty age‐ and sex‐matched rheumatoid arthritis (RA) patients and 30 non‐rheumatic disease individuals were selected for comparison. An experienced radiologist reviewed 24 CV, 20 CTr, 2 SC, and 1 MS joints from a thorax CT for each patient. All joints were classified as: normal (0); suspicious (1), mild (2), moderate (3), or severe (4).ResultsTotal CV and CTr joint scores differed between diseases (p < .001). Male AS patients had higher CV and CTr scores than female AS patients (male CV score: 52 [range 0–96] and CTr score: 22 [range 0–80]; female CV score: 20 [range 0–96] and CTr score: 12 [range 0–79]). Strong negative correlations were detected in AS patients between chest expansion and CV (r = −0.703 p = .007) and CTr (r = −0.763 p = .002) joint involvement; positive correlations between CV and CTr joints, and modified Stoke Ankylosing Spondylitis Spinal Score (p < .05); and no significant association for MS and SC joints.ConclusionsCV and CTr joint involvement on thorax CT was more severe in AS and negatively affected chest expansion. The use of thorax CT scans performed for other indications in the examination of these joints may be advantageous for the early beginning of rehabilitation programs targeted at maintaining chest mobility.
Techno‐nationalism or building a global science and technology commons? (but what about China?)
Authors: Lynn Leonard , Salzman Hal 
Published: August 2023

AbstractAs a cold war with China heats up, the U.S. and other members of the G7 need new approaches to their science and technology innovation (STI) policies. Dominance on the innovation frontier is no longer possible through traditional techno‐nationalist policies that view nations as ‘competing’ through exclusive STI development. Instead, we must recognise that talent and intellectual property are globally distributed, and thus build global collaborations that draw on the world's greatest talent while providing benefits equitably in a global STI commons. We need to recognise this new reality, not only for the benefits this would confer on humankind, but also to contend with China's growing STI capabilities and, eventually perhaps, integrating China into a system of global collaboration. Additionally, and importantly, national policies must recognise the geographically untethered operations of multinational enterprises that are the developers and/or repositories of STI but have weak ties to any one nation, thus blunting policies that try to contain STI within a country's borders. In this paper, we suggest approaches to advance these goals for global STI based on theories and cases of collective action.
Clinical validation of the nursing diagnosis risk for disturbed maternal–fetal dyad in high‐risk pregnancy: A case–control study
Authors: Mendes Ryanne C. M. G. , Morais Sheila C. R. V. , Pontes Cleide M. , Frazão Cecília M. F. Q. , França Michelline S. , Lopes Marcos V. O. , Silva Gabrielle P. , Mangueira Suzana O. , Linhares Francisca M. P. 
Published: August 2023

AbstractPurposeTo obtain evidence of the clinical validity of the nursing diagnosis (ND) risk for disturbed maternal–fetal dyad in high‐risk pregnancy.MethodCausal validation of the ND through a case–control study performed in a university hospital with 155 high‐risk pregnant women: 31 cases and 124 controls. A causal association was found between the ND etiological factors and the occurrence of disruption of the symbiotic maternal–fetal dyad; an association was verified when the etiological factor presented a p‐value <0.05 and odds ratio >1.FindingsThe risk factor absent–inadequate prenatal care; populations at risk, such as young‐advanced maternal age and economically disadvantaged pregnant women; and association conditions, such as maternal conditions and compromised fetal oxygen transport, increased the outcome likelihood. The associated condition maternal illnesses appeared as a protective factor.ConclusionsEvidence of clinical validity of the ND risk for disturbed maternal–fetal dyad was obtained, and an association between etiological factors and disruption of the symbiotic maternal–fetal dyad was found.Implications for nursing practiceThe results contribute to advance scientific knowledge in nursing teaching, research, and practice and support the nursing process in high‐risk pregnancies.