bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo acoustic patterning of endothelial cells for tissue vascularization
Authors: Comeau Eric S. , Vander Horst Melinda A. , Raeman Carol H. , Child Sally Z. , Hocking Denise C. , Dalecki Diane 
Published: September 2023

AbstractStrategies to fabricate microvascular networks that structurally and functionally mimic native microvessels are needed to address a host of clinical conditions associated with tissue ischemia. The objective of this work was to advance a novel ultrasound technology to fabricate complex, functional microvascular networks directly in vivo. Acoustic patterning utilizes forces within an ultrasound standing wave field (USWF) to organize cells or microparticles volumetrically into defined geometric assemblies. A dual-transducer system was developed to generate USWFs site-specifically in vivo through interference of two ultrasound fields. The system rapidly patterned injected cells or microparticles into parallel sheets within collagen hydrogels in vivo. Acoustic patterning of injected endothelial cells within flanks of immunodeficient mice gave rise to perfused microvessels within 7 days of patterning, whereas non-patterned cells did not survive. Thus, externally-applied ultrasound fields guided injected endothelial cells to self-assemble into perfused microvascular networks in vivo. These studies advance acoustic patterning towards in vivo tissue engineering by providing the first proof-of-concept demonstration that non-invasive, ultrasound-mediated cell patterning can be used to fabricate functional microvascular networks directly in vivo.
Effective implementation of $$\text{L}{0}$$-regularised compressed sensing with chaotic-amplitude-controlled coherent Ising machines
Authors: Gunathilaka Mastiyage Don Sudeera Hasaranga , Kako Satoshi , Inui Yoshitaka , Mimura Kazushi , Okada Masato , Yamamoto Yoshihisa , Aonishi Toru 
Published: September 2023

AbstractCoherent Ising machine (CIM) is a network of optical parametric oscillators that can solve large-scale combinatorial optimisation problems by finding the ground state of an Ising Hamiltonian. As a practical application of CIM, Aonishi et al., proposed a quantum-classical hybrid system to solve optimisation problems of$$l_0$$l0-regularisation-based compressed sensing. In the hybrid system, the CIM was an open-loop system without an amplitude control feedback loop. In this case, the hybrid system is enhanced by using a closed-loop CIM to achieve chaotic behaviour around the target amplitude, which would enable escaping from local minima in the energy landscape. Both artificial and magnetic resonance image data were used for the testing of our proposed closed-loop system. Compared with the open-loop system, the results of this study demonstrate an improved degree of accuracy and a wider range of effectiveness.
Coagulation markers as independent predictors of prostate cancer aggressiveness: a retrospective cohort study
Authors: Lei Xu , Zhang Tengfei , Deng Zhixuan , Jiang Tao , Hu Yang , Yang Ning 
Published: September 2023

AbstractCoagulation system activation is commonly observed in tumor patients, including prostate cancer (PCa), with coagulation markers proposed as potential prognostic indicators for cancer severity. However, the correlation between these markers and clinicopathological features in PCa remains unclear. Thus, this study investigates the association between comprehensive coagulation markers and clinicopathological characteristics in PCa patients. A retrospective evaluation of 162 PCa patients diagnosed and categorized into low-intermediate-risk or high-risk groups based on clinical and pathological features was conducted. Coagulation markers, including fibrinogen (FIB), d-dimer (DD), activated partial thromboplastin time (APTT), prothrombin time (PT), prothrombin activity (PTA), thrombin time (TT), platelet count (PLT), and international normalized ratio (INR), were assessed. Univariate and multivariate logistic regression analyses were performed to determine associations with clinicopathological features. FIB and DD were confirmed as independent factors associated with high-risk PCa. Furthermore, FIB and DD levels showed significant positive correlations with clinical parameters, including PSA levels, ISUP grade, T stage, N stage, and M stage. Our findings suggest that FIB and DD hold promise as independent prognostic biomarkers for risk stratification in PCa. These coagulation markers may aid in assessing PCa severity and guiding personalized treatment strategies.
A constructive airborne‐ground matrix algorithm for modern telecommunication systems
Authors: Arun Raj A Samson , Xavier S Basil , Kathrine G Jaspher Wilisie , Silas Salaja , J Andrew 
Published: September 2023

AbstractConventional Mobile Communication Systems (MCS) reliably transfer critical messages from authorised remote information sources like military bases and ground control stations in the war field. As tactical advancement grows rapidly, the challenges of transmitting tactical messages via conventional satellite methods increase the processing overhead related to cost, Line of Sight (LOS) communication, packet loss, delay, and retransmission requests. Modern mobile communication systems use Airborne Node Networks (ANN) between satellites and Mobile Ground Nodes (MGNs) as they provide many advantages in mobile communication systems. Hence airborne network reduces the burden of satellites as they are only used as relay stations. The mobility problem caused by ANN and MGNs is solved by proposing a novel constructive airborne‐ground matrix algorithm known as the Who‐To‐Whom (WTW) matrix. With the help of this matrix acting as a reference index, it determines which nodes relate to whom at every time interval T in the tactical environment. This WTW matrix holds precise status/information about connectivity among all stakeholders in the operating environment by carefully and effectively accounting for frequent location changes. The methodology of the proposed matrix is that it contains the physical parameters of the nodes and their behaviour in the tactical environment. The WTW matrix construction algorithm discusses how the reference matrix is constructed in every aerial node to monitor the mobile ground nodes by leading them to safety and providing aerial guidance as they move along the tactical environment. The performance metrics are measured with other existing schemes, and the merits and demerits of the proposed WTW matrix are identified and discussed in detail.
Sporttherapie bei schizophrenen Psychosen: Von der Idee bis zur
Leitlinie
Authors: Falkai Peter , Schwaiger Rebecca , Schmitt Andrea , Röll Lukas , Maurus Isabel 
Published: September 2023

ZusammenfassungSchizophrene Psychosen sind aufgrund der Einführung von Antipsychotika
vor ca. 70 Jahren in Verbindung mit der Implentierung spezifischer
Psychotherapien heute deutlich besser behandelbar. Im Bereich der
Negativsymptomatik und krankheitsassoziierten kognitiven Defiziten sind die
aktuellen Behandlungsmöglichkeiten jedoch weiter limitiert. In den
letzten 15 Jahren konnten randomisiert kontrollierte Studien (RCTs) zeigen, dass
körperliches Training und insbesondere Ausdauertraining einen
umfassenden ergänzenden Behandlungsansatz darstellen könnte und
zu einer signifikanten Verbesserung der Positiv-, aber insbesondere auch der
Negativsymptomatik und von kognitiven Defiziten zu führen vermag. In der
Folge hat Sporttherapie bei schizophrenen Psychosen Eingang in die nationale
Behandlungsleitlinie der Deutschen Gesellschaft für Psychiatrie,
Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN), aber auch in
europäische Empfehlungen, wie der European Psychiatric Association (EPA)
Einzug gehalten. Im nächsten Schritt muss eine breite Implementierung in
die Versorgung erfolgen, was mit der Einführung des „Living
guideline“ Formats (hier erfolgt mindestens einmal jährlich eine
Aktualisierung) besser als bisher möglich sein wird. Die vorliegende
Arbeit bildet, basierend auf einem narrativen Review, den Prozess der
Implementierung von Sporttherapie bei schizophrenen Psychosen von ihren
Anfängen bis zur Verankerung in Leitlinien ab und kann analog
für andere Therapieformen gelten.
Physiological Responses Associated with Nordic-Walking and Walking in
Middle-age Women
Authors: Wiacek Magdalena , Natora Justyna , Zubrzycki Igor Z , Tomasiuk Ryszard 
Published: September 2023

AbstractThis study aimed to analyze the influence of supervised 12-week walking (W) and
Nordic-walking (NW) programs on changes in specific physiological parameters in
middle-aged women 55.40±7.87 and 52.58±6.91 years of age,
respectively. Body mass, fat tissue percentage, muscle tissue percentage,
systolic blood pressure, diastolic blood pressure, resting pulse, and maximum
oxygen uptake were measured at the beginning and end of the exercise program.
Intra- and intergroup differences in physiological parameters as a function of
the preparation period were analyzed using bootstrap analysis. Clinically
reliable changes for a specific subject in the W and NW programs were analyzed
using the Reliable Change Index (RCI). The results of this study indicate that
more distinct differences were observed in the NW group. However, both programs
improved the parameters studied. Nevertheless, an analysis of the RCI indicates
that the W provides results similar to, if not better than, NW for increasing
neuromuscular, cardiovascular, and cardiorespiratory fitness. This study leads
us to the conclusion that the W is not less efficient than the NW for
middle-aged women.
Point-of-Care Ultrasound for the Tip of the Endotracheal Tube: A Neonatologist Perspective
Authors: Sahin Ozlem , Tasar Sevinc , Colak Derya , Yavanoglu Atay Funda , Guran Omer , Mungan Akin Ilke 
Published: September 2023

Objective Point-of-care ultrasound (POCUS) has been reported to reduce radiation exposure and has been shown to be a reliable bedside technique to confirm endotracheal tube (ETT) placement, but evidence in neonates is still limited. The aim of this study was to compare the effectiveness and reliability of POCUS performed by a neonatologist, as an alternative to chest radiography (CXR) for the optimal position of ETT.
Study Design Newborns who underwent intubation were included in this prospective observational study. The CXR was used to evaluate the position of the ETT tip and categorized into three groups: above the T1, between the T1 and T3, and below the T3 vertebra. An experienced neonatologist measured the distance between the ETT tip and the upper border of the aortic arch from the suprasternal notch with ultrasonography (US). A 5 to 10 mm measurement was considered as the optimal distance, and the position was classified into three categories: correct, high, and deep.
Results Among 91 measurements performed on 63 intubated patients with US, 73 (80%) were within the 5 to 10 mm range (correct position). Of these, 61 (92.4%) were determined to be between T1 and 3 vertebrae in CXR. There was no significant difference between the two methods, and the US had an excellent ability to distinguish the correct position of the ETT. The distance measured by the US for the ETT tip to be located between the T1 and T3 vertebrae on CXR should range between 6.17 and 9.0 mm.
Conclusion This study showed that the US by an experienced neonatologist is an easy and feasible alternative to determine the position of the ETT in the neonatal intensive care unit.
Key Points
Management of Gestational Gigantomastia with Goldilocks Procedure after Mastectomy: A Case Report and Review of Literature
Authors: Yoon Jeong Ho , Kang Taewoo , Park Heeseung , Eun Kim Kyoung , Bong Nam Su , Young Go Ju , Hwan Bae Seong 
Published: September 2023

AbstractGestational gigantomastia is characterized by the rapid growth of breasts during pregnancy. The treatment method of gestational gigantomastia is unclear; if the medical treatment is ineffective, surgery is considered. However, sufficient research on which method is best to perform breast reconstruction for the gestational gigantomastia patient has not yet been conducted. Our patient was young and had aesthetic needs; thus, we did not recommend modified radical mastectomy. However, it was difficult for the patient to consider active reconstruction using an implant or autologous tissue because of the expected complications and economic problems. The patient had a thin body shape and very large breasts compared with the trunk. Therefore, breast volume was not significantly required after reconstruction. Additionally, we expected that a considerable portion of skin would remain after mastectomy as a tubular-shaped breast. It was expected that the Goldilocks technique would be sufficient to meet the patient's volume needs. Therefore, we proceeded with total mastectomy and reconstruction using the Goldilocks procedure. No complications were recorded after the operation; most of the patient's discomfort was resolved, and the shape and size of the breasts were satisfactory.
Necrotizing Otitis Externa: A Proposal for Diagnostic and Therapeutic Approach
Authors: Costa Marília Batista , Onishi Ektor Tsuneo 
Published: September 2023

Abstract
Introduction Necrotizing otitis externa has a high impact on the quality of life of patients and has shown a significant increase in its incidence in recent years. There has been a change in the profile of affected patients and a lack of consensus on the management of these patients.
Objective To develop a practical and effective care protocol to standardize the diagnostic and therapeutic management of necrotizing otitis externa.
Methods A retrospective cohort study of necrotizing otitis externa patients between January 2015 and December 2020.
Results There were 34 patients with two bilateral cases, totaling 36 ears. The mean age was 68.5, with a higher prevalence of males (76%). Diabetes was present in 97% of the samples. The involvement of cranial pairs was identified in 35% of the sample. Pseudomonas aeruginosa was the most frequent pathogen isolated, found in 50% of the cases. Among the cultures with bacterial agents isolated, 35% showed resistance to ciprofloxacin. The most frequent exam was computed tomography (94%). Hospital admission was indicated for 31 patients (91%), and ceftazidime was the most prescribed drug (35.5%). There were 11 recurrences (32%), and 12 patients (35%) had complications during treatment. Among the unfavorable outcomes, 12% persisted with some degree of peripheral facial paralysis, 6% maintained dysphagia, and 9% died of the disease.
Conclusions The present study developed a diagnostic and therapeutic protocol for the effective management of necrotizing otitis externa. This protocol is a dynamic tool and should be revised and updated as new demands emerge during its implementation.
Angioleiomyoma of the Sinonasal Tract: A Systematic Review of an Uncommon Clinicopathological Entity
Authors: Velletrani Gianluca , Maurizi Riccardo , De Padova Alessandro , Di Girolamo Stefano 
Published: September 2023

Abstract
Introduction Angioleiomyoma is a rare neoplasm that represents ∼ 0.2 % of all head and neck benign tumors and ∼ 2% of total cases of tumors of the sinonasal tract. It was once considered a possible subtype of leiomyoma, but, in the 2020 World Health Organization (WHO) classification of soft tissue tumors, it is accepted as a singular entity.
Objective To systematically review the existing literature on angioleiomyoma in the light of the new classification of soft tissue tumors.
Data Synthesis The present study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A comprehensive search in the PubMed, Cochrane, Scopus, and Google Scholar databases was performed in January 2022. The search items included the following keywords: nasal angioleiomyoma OR sinonasal angioleiomyoma OR nasal vascular leiomyoma OR sinonasal vascular leiomyoma. A total of 87 patients were evaluated. He age of the patients in the studies ranged from 15 to 88 years (mean age at diagnosis: 55.6 years). The most common site of involvement was the nasal septum (28.4 %), followed by the inferior turbinate (22.5%). The most common symptom was nasal obstruction (66.7%), followed by epistaxis (47.1%). Surgical excision represented the main treatment, and there was recurrence of pathology in only 1 case (0.9%).
Conclusion To our knowledge, only 87 cases of sinonasal-tract angioleiomyoma have been previously described. The results of the present review seem to confirm the rarity and the benign nature of this neoplasm, and they seem to confirm the necessity to improve the available data about sinonasal-tract angioleiomyoma.
Endoscopic Study of Ethmoidal Canals in Cadavers, Including a Histological Analysis of Their Contents
Authors: Felippu Alexandre Wady Debes , Morsch Thiago Picolli , Felippu André Wady Debes , Cascio Filippo , Oliveira Claudia Regina Gomes Cardim Mendes de , Felippu Alexandre , Voegels Richard Louis 
Published: September 2023

Abstract
Introduction The advent of the endoscope has enabled the use of the endonasal approach for a variety of diseases. Studying the ethmoidal canals is important for surgeries of the paranasal sinuses and the anterior base of the skull.
Objective To investigate the ethmoidal canals and evaluate their structure, the presence of vessels and nerves, their location, and to perform an anatomopathological study of their contents.
Methods We evaluated 20 cadavers (20 left and 20 right nasal cavities) through endoscopic dissection of the anterior base of the skull and exposure of the medial periorbita and dura mater; then, the ethmoidal canals were located and measured in relation to the anterior wall of the sphenoid sinus and between the ethmoidal canals, followed by removal of their content for histological analysis.
Results Vessels were present in 75% of the left anterior ethmoidal canals, 70% of the left posterior ethmoidal canals, 75% of the left middle ethmoidal canals, 85% of the right anterior ethmoid canals, and 64.5% of the right posterior ethmoid canals; 50% of the right middle ethmoidal canals contained one vessel.
Conclusion The ethmoidal canal does not necessarily contain an ethmoidal artery. Studies with a larger sample should be performed to quantify the correct proportion of arteries and ethmoidal canals.
Disease-Based Prognostication: Neuro-Oncology
Authors: Waite Kristin A. , Cioffi Gino , Malkin Mark G. , Barnholtz-Sloan Jill S. 
Published: September 2023

AbstractPrimary malignant and non-malignant brain and other central nervous system (CNS) tumors, while relatively rare, are a disproportionate source of morbidity and mortality. Here we provide a brief overview of approaches to modeling important clinical outcomes, such as overall survival, that are critical for clinical care. Because there are a large number of histologically distinct types of primary malignant and non-malignant brain and other CNS tumors, this chapter will provide an overview of prognostication considerations on the most common primary non-malignant brain tumor, meningioma, and the most common primary malignant brain tumor, glioblastoma. In addition, information on nomograms and how they can be used as individualized prognostication tools by clinicians to counsel patients and their families regarding treatment, follow-up, and prognosis is described. The current state of nomograms for meningiomas and glioblastomas are also provided.
Plant species, nitrogen status and endophytes are drivers of soil microbial communities in grasslands
Authors: Rasmussen Susanne , Parsons Anthony J. , Russell Julia , Bastías Daniel A. , Liu Qianhe 
Published: September 2023

Context There is concern that the introduction of ‘novel’ plant germplasm/traits could outpace our capacity to measure and so assess their impacts on soil microbial communities and function. Aim This study aimed to investigate the effects of plant species/functional traits, nitrogen (N) fertilisation and endophyte infection on grassland soil microbial communities within a short time span of 2 years. Methods Two field experiments with monoculture plots were conducted in a common soil. Experiment 1 compared grasses and legumes, using two cultivars of perennial ryegrass (Lolium perenne) that varied in fructan content, along with the legumes white clover (Trifolium repens) and bird’s-foot trefoil (Lotus pedunculatus) that varied in tannin content. Grass treatments received high and low N application levels. Experiment 2 compared the presence/absence of Epichloë strains in ryegrass, tall fescue (Schedonorus phoenix) and meadow fescue (Schedonorus pratensis). Soil microbial communities were analysed by using high-throughput sequencing of DNA isolated from bulk soil cores. Key results Higher abundance of ligninolytic fungi was found in grass soils and pectinolytic fungi in legume soils. Levels of N fertilisation and fructan in ryegrass had only minor effects on soil fungal communities. By contrast, N fertilisation or fixation had a strong effect on bacterial communities, with higher abundance of nitrifiers and denitrifiers in high-N grass soils and in legume soils than in low-N grass soils. Epichloë affected soil microbiota by reducing the abundance of certain fungal phytopathogens, increasing mycorrhizal fungi and reducing N-fixing bacteria. Conclusions Chemical composition of plant cell walls, which differs between grasses and legumes, and presence of Epichloë in grasses were the main drivers of shifts in soil microbial communities. Implications Impacts of farming practices such as mono- or poly-culture, N fertilisation and presence of Epichloë in grasses on soil microbial communities should be considered in pasture management.
Discriminating between sick and healthy faces based on early sickness cues: an exploratory analysis of sex differences
Authors: Tognetti Arnaud , Thunell Evelina , Zakrzewska Marta , Olofsson Jonas , Lekander Mats , Axelsson John , Olsson Mats J 
Published: September 2023

Abstract

Background and objectives
It has been argued that sex and disease-related traits should influence how observers respond to sensory sickness cues. In fact, there is evidence that humans can detect sensory cues related to infection in others, but lack of power from earlier studies prevents any firm conclusion regarding whether perception of sickness cues is associated with sex and disease-related personality traits. Here, we tested whether women (relative to men), individuals with poorer self-reported health, and who are more sensitive to disgust, vulnerable to disease, and concerned about their health, overestimate the presence of, and/or are better at detecting sickness cues.

Methodology
In a large online study, 343 women and 340 men were instructed to identify the sick faces from a series of sick and healthy photographs of volunteers with an induced acute experimental inflammation. Participants also completed several disease-related questionnaires.

Results
While both men and women could discriminate between sick and healthy individuals above chance level, exploratory analyses revealed that women outperformed men in accuracy and speed of discrimination. Furthermore, we demonstrated that higher disgust sensitivity to body odors is associated with a more liberal decision criterion for categorizing faces as sick.

Conclusion
Our findings give strong support for the human ability to discriminate between sick and healthy individuals based on early facial cues of sickness and suggest that women are significantly, although only slightly, better at this task. If this finding is replicated, future studies should determine whether women’s better performance is related to increased avoidance of sick individuals.