bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boundary Treatment for the Subsonic/Alfvénic Inner Boundary at 2.5 R
⊙ in a Time-dependent 3D Magnetohydrodynamics Solar Wind Simulation Model
Authors: Hayashi Keiji , Wu Chin-Chun , Liou Kan 
Published: September 2023

Abstract
A new magnetohydrodynamics (MHD) simulation model of the global solar corona and solar wind is presented. The model covers the range of heliocentric distance from 2.5 solar radii, so that coronal mass ejections at the earliest phase near the Sun can be treated in the future. This model is constructed by introducing a characteristics-based boundary treatment to an existing heliosphere 3D MHD model. In tailoring a set of characteristic equations for this new model, we assume that the coronal magnetic field is open to interplanetary space and that the solar coronal plasma is flowing outward everywhere at 2.5 solar radii. The characteristic equations for the subsonic/Alfvénic inner boundary surface are satisfied by altering the plasma density and/or temperature to maintain a polytropic relationship. In this article, the details of the characteristics-based boundary treatment for the middle of the corona (named CharM) are provided. The quasi-steady states of the solar wind derived from simulations with various choices of a parameter in the boundary treatments are compared and examined. Although further improvements are needed, we apply the new boundary treatment to simulations for three Carrington rotation periods from the minimum to maximum phase of the solar activity cycle, and show that an optimal choice yields a reasonable quasi-steady state of the transonic/Alfvénic solar wind matching the specified subsonic/Alfvénic plasma speed at 2.5 R
⊙.
The expression level of aspartate beta-hydroxylase (ASPH) and clinical importance in acute myeloid leukemia
Authors: Said Fadwa , El Ghammaz Amro M. , Shazly Mohamed A. , Azzazi Mohamed O. 
Published: September 2023

Background
Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by clonal expansion of myeloid progenitors in the bone marrow and peripheral blood. Aspartate β-hydroxylase (ASPH) is a membrane protein that promotes cellular motion. Recent studies have revealed that ASPH is an indicator of carcinoma in humans and is highly expressed in AML.

Patients and methods
The study included 30 AML patients diagnosed and classified by complete blood count with differential, bone marrow study, flow cytometric, cytogenetic, and molecular studies, and 10 normal participants of the same age group. The serum level of ASPH was measured in both cases and controls by enzyme-linked immunosorbent assay.

Results
The level of ASPH was significantly higher in patients than in controls (P < 0.001). Patients with mutant FLT3 had higher serum ASPH compared with those with wild FLT3 with a trend toward statistical significance (P = 0.074). Other clinical and laboratory variables had no relationship with ASPH levels in the blood.

Conclusion
This study detected a significant increase in ASPH levels in the blood of AML patients more than the controls, shedding the light on the role of ASPH in AML genesis and paving the way for the development of new medications that block ASPH's leukemogenesis effect in the future.
The beneficial therapeutic effects of statins, angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers on protein-C and protein-S activities in Egyptian patients with type-2 diabetes mellitus
Authors: Mohamed Enas M. , Kareem Heba S. , Zahran Shaimaa M. , El Sissy Maha H. 
Published: September 2023

Objectives
Patients with type-2 diabetes mellitus (T2DM) have an increased incidence of adverse cardiovascular events secondary to endothelial dysfunction, hypercoagulability, and decreased fibrinolysis. This study aimed to evaluate protein-C and protein-S activities and carotid intima-media thickness (CIMT) in patients with T2DM who were treated with statins and/or angiotensin-converting enzyme inhibitor (ACEI)/angiotensin-II receptor blockade (ARB).

Basic methods
One hundred and twenty patients with T2DM participating in the study were classified into groups based on their use of statins and ACEI/ARBs. Protein-C and protein-S activity and CIMT were compared.

Main results
Patients treated with both statins and ACEI/ARBs showed the highest levels of protein-C and protein-S activity (P < 0.001). This was followed by patients on statins alone and patients on ACEI/ARBs alone. Patients who were not on statin or ACEI/ARB therapy had the lowest levels of protein-C and protein-S activity. Moreover, we identified significant correlations between protein-C and protein-S activities and CIMT with hemoglobin A1c, cholesterol, and low-density lipoprotein.

Conclusion
ACEI/ARBs and statins have a critical impact on the hypercoagulable state characteristic of T2DM, potentially via increased levels of protein-C and protein-S activity. ACEI/ARBs also limited CIMT, an important surrogate marker for atherosclerosis.
Evaluation of a Fixed-dose Combination of Mebeverine and Chlordiazepoxide for Irritable Bowel Syndrome
Authors: Pratap Nitesh , Goyal Omesh , Jagtap Sumeet , Goswami Bhabadev , Kalita Partha Pratim 
Published: September 2023

Background:
To assess the effectiveness and safety of a fixed-dose combination (FDC) of mebeverine hydrochloride 135 mg and chlordiazepoxide 5 mg in the management of irritable bowel syndrome (IBS) in Indian patients.

Methods:
This was an 8-week, prospective, open-label, observational study. Patients (n = 60, age: 18–60 years) newly diagnosed with IBS and having anxiety symptoms (score ≥18 on Hamilton Anxiety Rating Scale [HAM-A]), who were prescribed the study drug as a part of routine practice were included.

Results:
All 60 enrolled patients completed the study. Patients’ mean standard deviation (SD) age was 37.45 (11.00) years; most were male (73.33%). The mean (SD) IBS-symptoms severity scale (IBS-SSS) score at baseline was 182.72 (84.39) indicating moderate symptom severity; the mean change at week 8 was 85.50 (82.69), P < 0.0001 (primary endpoint), and at week 4 was 64.70 (58.44), P < 0.0001. The mean (SD) IBS-36 score was 78.33 (41.87) at baseline and decreased at week 8 by 45.88 (34.92), P < 0.0001. At week 8, majority of patients achieved a ≥50-point improvement in IBS-SSS score (73.33%), and a ≥10-point improvement in IBS-36 scores (88.33%). The mean (SD) HAM-A total score was 26.97 (6.72) at baseline and decreased to 10.45 (8.99) at week 8, P < 0.0001. Three adverse drug reactions unlikely to be related to study drug were reported in two patients (nausea n = 1, headache n = 2). Good tolerability to study drug was reported by all patients and investigators at week 8.

Conclusion:
The FDC of mebeverine hydrochloride and chlordiazepoxide was effective in the treatment of IBS and was well tolerated.
Proton-Pump Inhibitor Therapy in Patients with Erosive Esophagitis: A Real-World Scenario
Authors: Jain Mayank 
Published: September 2023

Background:
Gastroesophageal reflux disease (GERD) has three classical phenotypes, namely erosive esophagitis (EE), nonerosive reflux disease, and Barrett’s esophagus. Patients with GERD are managed with lifestyle changes, dietary interventions, and proton-pump inhibitors (PPI).

Aim:
To determine the patterns of PPI use in patients with documented EE.

Methods:
This prospective study recruited all patients with symptoms of GERD (heartburn and/or regurgitation with or without chest pain) and documented significant reflux esophagitis (Los Angeles grading LA-B or beyond on endoscopy). Lifestyle and dietary changes were initiated and all patients were prescribed twice daily PPI for 8 weeks. PPI was tapered as the requirement beyond 8 weeks. Follow-up was done at weeks 8, 12, and 24. The outcomes analysed included number of patients where complete PPI withdrawal was possible at week 24 and determinants of continued PPI use at 24 weeks of therapy. Statistical analysis was performed using Chi-square test, Mann–Whitney U-test, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio. P < 0.05 was considered statistically significant.

Results:
The study cohort included 53 patients-42 with reflux esophagitis LA-B and 11 with reflux esophagitis LA-C (median age 46 years [22–77 years]; 28 [52.3%] males). There was significant difference in consumption pattern of PPI between week 12 and 24 (P = 0.008). At week 12, 15.1% were off PPI and 67% required intermittent dosing. At week 24, 45.3% of cases were off PPI therapy and 43.4% required intermittent dosing. Only 11.3% patients continued drug use at once a day dosing. Lower body mass index (BMI) (P 0.01) and age (P 0.01) were linked with complete PPI withdrawal at week 24.

Conclusion:
The present study highlights that PPI withdrawal is possible in 15.1% and 45.3% cases with EE after week 12 and week 24 of therapy, respectively. Lower BMI and age are likely to be associated with PPI withdrawal at week 24.
A Cross-Sectional Study to Assess Resilience and Perceived Social Support among Cancer Patients
Authors: Rani Ruchika , Chadha Lisa , Gupta Sweety 
Published: September 2023

Introduction:
Cancer is one of the health emergencies across the globe causing the highest mortality rates. Its dimensions are far beyond the physical illness as it causes a long-lasting psychological impact on the patient as well as family mental health due to its poor prognosis, low survival rates, and substantial distress due to its treatment modalities. This study aims to assess the level of resilience and perceived social support among cancer patients.

Subjects and Methods:
A cross-sectional survey was conducted from January 2020 to April 2020. A total of 405 cancer patients were enrolled in this research study who were attending the oncology outpatient department at our institute. The data was collected through planned interviews using Connor–Davidson Resilience Scale and the multidimensional scale of perceived social support to assess the level of resilience and perceived social support among patients. Data were analyzed using descriptive and inferential statistics.

Results:
The findings revealed that the highest level of resilience was shown among the patients who are self-efficient with a mean score of 5.36 ± 1.392 while the respondents obtained the maximum social support from their family with a mean score of 19.37 ± 3.653. It was found that there was a strong positive correlation between resilience and perceived social support, which was statistically significantP< 0.05), whereas no association was found between the level of resilience and perceived social support scores with sociodemographic variables (P < 0.05).

Discussion:
Promoting resilience and good social support during illness should be an important component of cancer care.
Domestic Violence and its Associated Factors among Married Women of Varanasi
Authors: Srivastava Jyoti 
Published: September 2023

Background:
Domestic violence experienced by married women with mental illness, with physical illness (obstetric and gynecological morbidity) and with no illness (normal healthy women), is a nearly universal phenomenon.

Materials and Methods:
The study design was cross-sectional case–control study. A total of 165 married women (group: mental illness, with physical illness and with no illness) between the ages of 16 and 45 were randomly selected. The study was conducted in the hospital, which is a tertiary care center with a huge catchment area that extends from Uttar Pradesh, to Bihar, and parts of Madhya Pradesh and Nepal. People living in this area largely come from middle, lower, and poor socioeconomic strata and have low level of literacy.

Results:
Perceived factors were reported exclusively by the married women with mental illness: alleged disrespect to elders, considers wife as property of husband, disability, instigated by family members, violating family norms, tradition of wife abuse in the family, unacceptable abnormal wife, unacceptable wife/daughter-in-law with mental illness, antisocial personality traits, and cannabis use dependence.

Conclusions:
Domestic violence (spousal) is most frequent and severe in married women with mental illness, then in married women with physical illness, and least in healthy married women. Higher husband's age and lower wife's age were predictors of domestic violence perpetrated by husbands in married healthy women.
Occupational Stress and Family Functioning among Working Women of Sonitpur District, Assam
Authors: Neog Munmi , Ahmed Nurnahar , Kollipara Sandeep 
Published: September 2023

Background:
Modern life is full of stress. Occupational stress is a type of psychological stress that affects not only employees' health and well-being but also the productivity of organizations. Working women are typically responsible for their homes while also meeting professional obligations. When a woman returns home under the stress and expectations of her career, she may encounter obstacles and difficulties in carrying out her domestic responsibilities.

Aim:
This study aimed to assess occupational stress and family functioning among working women, working in selected workplaces in Sonitpur district.

Materials and Methods:
A descriptive research design was adopted for the study. A total of seventy working women were selected through convenient sampling technique. Sociodemographic data were collected by administering a self-structured sociodemographic pro forma. Occupational stress and family functioning were assessed using standardized tools such as Occupational Stress Index and McMaster Family Assessment Device, respectively.

Results:
About 64.3% (f = 45) of the working women had a moderate level of occupational stress. Communication, roles, affective response, affective involvement, and behavior control domains of family functioning showed to be unhealthy. However, problem-solving and general functioning domains of family functioning were found to be healthy among working women.

Conclusion:
The study findings revealed that the majority of the working women have moderate level of occupational stress and unhealthy functioning in certain domains of family functioning.
Depression, Anxiety, and Stress among Undergraduate MBBS and Nursing Students in Erode, Tamil Nadu
Authors: Periasamy Panneerselvam , Vajiravelu Suganthi , Chandrabose A. , Sasikala G. , Manivannan Janani , Umashankar Aishwarya 
Published: September 2023

Background:
The main psychological stress among medical students was associated with anxiety and depression. Fear of unforeseeable situations, using equipment, speaking with patients, etc., is a typical issue among students. The two factors that are most directly associated with poor emotional states are physical and mental health.

Methodology:
Students from the Erode district of Tamil Nadu were recruited for this cross-sectional study. The study involved 273 undergraduate students who were randomly selected. Participants were selected by a systematic, random sampling technique. To measure the study's outcomes, the depression, anxiety, and stress scale-42 with 42 items was employed. Statistical significance was shown using aP= 0.05.

Results:
Among the 273 respondents, 80 (29.30%) were male and 193 (70.70%) were female. Among undergraduate students in Tamil Nadu's Erode district, there was a 40.29% prevalence of depression, a 40.39% prevalence of anxiety, and a 31.04% prevalence of stress. Female students had a 10.25 depression score than male students' 7.75 score. Furthermore, female (11.76) students had more stress scores than male students (9.30). Nursing and MBBS students had more anxiety.

Conclusions:
Stress, anxiety, and depression all have disturbingly high prevalence rates. Therefore, it is strongly advised to implement stress reduction strategies and to set up a student counseling center.
Pengaruh Keteladanan Guru Pendidikan Agama Kristen Dalam Pembentukan Karakter Anak Yang Berkebutuhan Khusus Di Sekolah Minggu Gereja Kristen Setia Indonesia Menining
Authors: Christia Verra Ria , Iswahyudi Iswahyudi , Setiawan Jimmy , Bintoro Wahyu 
Published: September 2023

The teacher's example in character building is the beginning of making children with special needs qualified. The teacher's example is the basis for producing children with special needs to be of good character. It turns out that in creating the formation of children's character, it must be based on various aspects, one of which is seen from the teacher, so that children can imitate the attitudes and examples of their own teachers. The example of a teacher can be seen in daily activities with children with special needs, there will be clearly seen how the example of a teacher in educating children with special needs is. A teacher has the task of educating, instilling good character in children with special needs. This writing tries to find the influence of the teacher's example in shaping the character of children with special needs. The teacher's example is the basis for the formation of the child's character, and the teacher must also be a good example for children with special needs. Various tools and facilities that become supporters in creating a comfortable atmosphere are needed in the teaching process so that the child's learning process is not boring. The main purpose of the research is to find out how much influence the example of a teacher sees by children with special needs in character building.

Keteladanan guru dalam pembentukan karakter merupakan awal menjadikan anak berkebutuhan khusus berkualitas. Keteladanan guru menjadi dasar supaya menghasilkan anak-anak yang berkebutuhan khusus menjadi berkarakter yang baik. Ternyata, dalam menciptakan pembentukan karakter anak, harus didasari oleh berbagai aspek salah satunya adalah dilihat dari gurunya, sehingga anak dapat menirukan sikap dan keteladanan yang dimiliki oleh gurunya sendiri. Keteladanan seorang guru dapat dilihat dalam kegiatan sehari-hari bersama anak yang berkebutuhan khusus, di situ akan terlihat dengan jelas bagaimana keteladanan seorang guru dalam mendidik anak yang berkebutuhan khusus tersebut. Seorang guru memiliki tugas mendidik, menanamkan karakter yang baik kepada anak berkebutuhan khusus. Penulisan ini mencoba mencari pengaruh atas pengarug keteladanan guru dalam pembentukan karakter anak berkebutuhan khusus. Keteladanan yang dimiliki guru menjadi dasar pembentukan karakter anak, dan guru juga harus bisa menjadi contoh yang baik bagi anak yang berkebutuhan khusus. Berbagai alat dan sarana yang menjadi pendukung dalam menciptakan suasana yang nyaman sangat dibutuhkan dalam proses mengajar agar proses belajar anak tidak membosankan. Tujuan utama dari penelitian adalah untuk mengetahui seberapa besar pengaruh keteladanan seorang guru yang dilihat oleh anak berkebutuhan khusus dalam pembentukan karakter.
Treatment of leachate solid wastewater and protein-rich biomass production using Ceratophyllum demersum (Linnaeus, 1753)
Authors: Tekoğul Hatice 
Published: September 2023

The present study, conducted in 2018, aimed to treat landfill leachate using the Ceratophyllum demersum plant and convert the wastewater nutrients into protein-rich biomass. The experiment was carried out for 45 days in an enriched medium with ½ Hoagland nutrient solution. Regarding the experimental setups, C. demersum cultivation was performed in four different dilution ratios (100%, 75%, 50%, and 25%) in the landfill leachate. The changes in the chemical properties of the wastewater (pH, NO₄⁻-N, NO₂⁻-N, NO₃⁻-N, and o-PO₄³⁻) were measured. The values in the leachate and after treatment were measured as follows: NH₄⁺-N ranged from 18.03 to 476.2 mg/L, NO₃⁻-N ranged from 5.0 to 33.98 mg/L, NO₂⁻-N ranged from 1.49 to 7.06 mg/L, and PO₄³⁻-P ranged from 27.99 to 145.4 mg/L. The protein yield (CP prot) in the experimental groups at the end of the 45-day study was as follows: T1 = 20.90%, T2 = 36.68 %, T3 = 41.78%, T4 = 47.43% and T5c = 49.56%. These results demonstrate that aquatic plants can be utilized in wastewater treatment and as animal feed due to their high protein yield. In my research, a completely nature-friendly treatment technique was used to reduce water pollution without using any chemicals. Published on September 11, 2023 CDT
Spawner weight and ocean temperature drive Allee effect dynamics in Atlantic cod, Gadus morhua: inherent and emergent density regulation
Authors: Winter Anna-Marie , Vasilyeva Nadezda , Vladimirov Artem 
Published: September 2023

Abstract. Stocks of Atlantic cod, Gadus morhua, show diverse recovery responses when fishing pressure is relieved. The expected outcome of reduced
fishing pressure is that the population regains its size. However, there are also cod stocks that seem to be locked in a state of low abundance from
which population growth does not occur (or only slowly occurs). A plausible explanation for this phenomenon can be provided by the Allee effect, which
takes place when recruitment per capita is positively related to population density or abundance. However, because of methodological limitations and
data constraints, such a phenomenon is often perceived as being rare or non-existent in marine fish. In this study, we used time series of 17 Atlantic cod stocks to fit a family of population equations that consider the abundance of spawners, their
body weight and sea water temperature as independent components of recruitment. The developed stock-recruitment function disentangles the
effects of spawner abundance, spawner weight and temperature on recruitment dynamics and captures the diversity of density dependencies
(compensation, Allee effect) of the recruitment production in Atlantic cod. The results show for 13 cod stocks an inherent spawner-abundance-related Allee effect. Allee effect strength, i.e., the relative change between
maximum and minimum recruitment per capita at low abundance, was increased when recruitment production was suppressed by unfavorable
changes in water temperature and/or in spawner weight. The latter can be a concomitant of heavy fishing or a result of temperature-related altered
body growth. Allee effect strength was decreased when spawner weight and/or temperature elevated recruitment production. We show how
anthropogenic stress can increase the risk of Allee effects in stocks where ocean temperature and/or spawner weight had been beneficial in the past
but are likely to unmask and strengthen an inherent Allee effect under future conditions.