bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMANFAATAN TEMBANG MIJIL SEBAGAI SUMBER BELAJAR MATA PELAJARAN IPS TERPADU
Authors: Anjassari Risma Vitrinovita , Widda Djuhan Muhammad 
Published: July 2023

Ilmu Pengetahuan Sosial merupakan salah satu mata pelajaran yang memiliki tingkat keluasan materi yang tinggi. Karena itu inovasi dalam pengelolaan materi belajar sangat dibutuhkan agar pembelajaran tetap menarik antusias belajar siswa dan meningkatkan pemahaman siswa pada materi ajar IPS. Inovasi materi pembelajaran dapat dilakukan dengan mengkolaborasikan materi ajar dengan bahan ajar lain. Adapun penelitian ini dirancang menggunakan metode penelitian kulatitatif deskriptif dengan bentuk analisis uraian dari data yang telah dikumpulkan. Pengambilan data dilakukan dengan cara observasi, wawancara dan dokumentasi. Partisipan penelitian berasal dari siswa dan guru IPS kelas VII di MTsN 2 Ponorogo. Berdasarkan hasil analisis data pada penelitian ini mengenai penggunaan tembang Mijil sebagai bahan belajar siswa dalam mempelajari materi ajar IPS terpadu kelas VII MTsN 2 Ponorogo. Memberikan temuan bahwasanya 1) strategi pemanfaatan tembang mijil sebagai sumber belajar mata pelajaran IPS terpadu dapat berjalan dengan baik. 2) efektifitas pemanfaatan tembang mijil sebagai sumber belajar mata pelajarn IPS terpadu menunjukkan hasil yang baik. 3) hambatan yang muncul dalam pemanfaatan tembang mijil sebagai sumber belajar mata pelajaran IPS terpadu ada tiga yakni menumbuhkan minat belajar siswa terhadap budaya, persispan guru dalam mempelajari tembang mijil, dan fasilitas yang mendukung belajar siswa dalam mengeksplore materi ajar.
Integrating Embedment and Creep Behavior for Multisize Proppant in Shale: Conceptual Model and Validation
Authors: Cheng Qiaoyun , Zhou Sandong , Li Bobo , Pan Zhejun , Liu Dameng , Yan Detian 
Published: July 2023

Summary
The embedment of multisize proppant in fractures and the creep behavior of the shale will affect fracture permeability, yet the combination of the two factors has not been well studied and understood. In this work, the impact of graded arrangement of multisize proppant on fracture permeability is studied considering proppant embedment and shale creep in a hydraulic fracture. The Hertz contact theory is used to quantify the depth of embedment for proppant with different particle sizes, and the Burgers model is used to describe the creep behavior of shale. Then, a permeability model considering the effects of multisize proppant embedment with shale creep is developed and verified. The results show that, under the combined effect of shale creep and proppant embedment, the reduction in permeability of the proppant arrangement with equal amount of three particle sizes is about twice that of two particle sizes. It also shows that there is an optimal Young’s modulus ratio that allows for minimal proppant embedment when the Young’s moduli of proppant and shale are in the same order of magnitude. Moreover, creep is positively correlated with loading pressure, loading time, and clay mineral content in the shale and there is a clear correspondence between shale creep, fracture width, and permeability variation. It is suggested that proppant type, size, mixing ratio, and fracturing parameters for shale reservoirs should be optimized by combining reservoir mineralogy and rock mechanics to reduce the cumulative effect of shale creep on long-term productivity. This work is useful for optimizing the hydraulic fracturing design for shale reservoirs and improving the efficiency of hydraulic fracturing to increase permeability.
Implications of COVID-19 vaccination heterogeneity in mobility networks
Authors: Yuan Yuan , Jahani Eaman , Zhao Shengjia , Ahn Yong-Yeol , Pentland Alex 
Published: July 2023

Abstract
Our study utilizes network science to examine how uneven vaccine distribution affects mass vaccination strategies in the United States. Using mobility network data and epidemiological models, we find that distributing a fixed quantity of additional vaccines across Census Block Groups (CBGs) can vary case count reductions by up to 200%. This highlights the impact of vaccination heterogeneity on mobility networks in epidemic outcomes. Our efficient algorithm identifies optimal vaccine distribution for maximum case reduction. Simulations show a possible 9.5% decrease in case numbers with just a 1% increase in the national vaccination rate if vaccines are optimally distributed. These results surpass other vaccine distribution models. Our findings underline the need for policymakers to understand the interaction between vaccination patterns and mobility networks, suggesting that grasping geographical vaccine uptake variations could be as crucial as raising the overall vaccination rate.
An Efficient and Secure Initial Network Entry Protocol (ESINEP) for IEEE 802.16
Authors: Kahya Noudjoud , Ghoualmi Nacira 
Published: July 2023

Abstract
The most important phase to established communication between mobile station and base station is the Initial Network Entry Process. This process has vulnerabilities against malicious attacks that affect communication efficiency. Although several Initial Network Entry protocols are proposed, however most of them suffer from several weaknesses like vulnerabilities to varied attacks, low communication efficiency with using a high complexity of protocol structure. In order to overcome these shortcomings, we propose astrong mechanism and new method of authentication scheme using the elliptic curve digital signature algorithm. The proposed security protocol, named ESINEP “An Efficient and Secure Initial Network Entry Protocol”, used to share a secure key between mobile station and base station to authenticate each other and to secure communication. While designing ESINEP our main aims are assure: message integrity, source authentication, low communication cost, the fast verification and efficient exchange of messages. Finally, a formal security verification using Scyther tools concludes that ESINEP is secure against the existing attacks.
2.3 GHz Microstrip Rectangular Structured Hybrid Coupler for WiMax applications
Authors: Ramdedovic Amel , Imeci Taha 
Published: July 2023

Abstract
The paper depicts a symmetric microstrip coupler designed for WiMax applications in the frequency range of 2.32 - 2.52GHz. The proposed coupler is comprised of four resonator structures attached in parallel to the ports providing lowered isolation and increased insertion loss and coupling factor. Furthermore, the presented microstrip coupler is simulated utilizing the Sonnet Suites software with the numerical approximation of the mathematical derivation of MoM (Method of Moments) for the symmetrical structure. The simulated and fabricated results show high resemblance with the data acquired after the simulation with input match being below -20dB, insertion loss and coupling factor almost -3.0 dB and isolation factor below -50dB. Approximate values of the measured design are -15.48dB, -3.86dB and -46.63dB respectively Moreover, the dielectric substrate utilized for the proposed geometry of the microstrip coupler is FR4 with ε_r=4.4 with thickness of 1.55mm.The proposed coupler is relatively inexpensive, reliable in the provided frequency range and could be used in wireless communication applications.
A Large-scale multi-objective firefly algorithm based on Reward and punishment mechanisms and Adaptive dimensional reorganization
Authors: Pan Ningkang , Lv Li , Xiao Renbin , Wang Hui , Cui Zhihua 
Published: July 2023

Abstract
Multi-objective optimization problems with large-scale variables are the focus and difficulty of current research in the field of multi-objective evolutionary algorithms. In order to cope with the problem of "dimensional catastrophe", this paper proposes a large-scale multi-objective firefly algorithm based on reward and punishment mechanisms and adaptive dimensional reorganization. First, a reward and punishment mechanisms is proposed to make full use of the information of the solution itself, so that the population can break the constraint and rapidly approach the Pareto frontier, effectively improving the convergence of the population; then, an adaptive dimensional reorganization mechanism is proposed to select individuals with large differences according to different iteration periods to interact and learn from each other, effectively improving the diversity of the population. In the experimental part, to verify the effectiveness of the algorithm, the UF series and the variable expanded ZDT series, 15 test problems are selected for simulation experiments and compared with 8 advanced large-scale optimization algorithms, the results show that L-MOFA-RA has the advantages of fast convergence speed and high convergence accuracy, and the comprehensive experimental results show that compared with the comparison algorithm L-MOFA-RA has better optimization performance. The comprehensive experimental results show that L-MOFA-RA has better optimization performance compared to the comparison algorithm.
Meditation practice improves body balance compared to stability exercises alone
Authors: Anchisi Davide , Ros Brenno , Sepulcri Luigino 
Published: July 2023

Abstract
Sport and competitions stress athletes both physically and mentally. Physical training strengthens muscular and metabolic capabilities, while mental training reduces psychological load and negative emotions. Meditation practice helps athletes to reach better results in many sports, but evaluating only sport results makes it difficult to disentangle the specific effects of meditation contributing to performance. Our aim was to evaluate if meditation practice may benefit body balance, a basic skill relevant for action execution and performance. 81 high school students were trained in body balance for six weeks through balance and stabilization exercises and to stand on a fit-ball. 42 of them were trained in meditation, which practiced during the same six weeks (meditation group), the remaining 39 did not (control group). Core stability, tested before and after the training period, improved in both groups to a similar extent. On the other hand, the meditation group developed a much greater skill on fit-ball than the control group: the hazard rate of falling was reduced by 67 %. Our results suggest that for a more difficult task, meditation can increase learning and execution, and that introducing meditation in athletes' training routine may be of value for balance control and performance.
Oncogenic KRAS-induces necroptotic priming of pancreatic neoplasia
Authors: Tishina Sofya , Dahlhaus Alina , Androulidaki Ariadne , Kotliar Michael , Mulalic Lejla , Rakhsh-Khorshid Hassan , Hocher Florian , Stroh Jenny , Beck Julia , Manik Marta , Williams Riley , Gülcüler Gülce , Abdallah Ali , Bebber Christina , Reese Moritz , Lim Jonathan , Trauzold Anna , Quaas Alexander , Brägelmann Johannes , Beleggia Filippo , Pasparakis Manolis , Liccardi Gianmaria , Balachandran Siddharth , Astsaturov Igor , Von Karstedt Silvia 
Published: July 2023

Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer mortality. PDAC expresses high levels of caspase 8, a central enzyme controlling various types of regulated cell death. Here, using genetically engineered mouse models we find that oncogenic KRAS-driven neoplastic transformation induces a transcriptional state of necroptotic priming, but necroptosis itself is counter selected against through co-upregulation of caspase 8. Mechanistically, expression of the driver oncogene KRAS induced a STING-dependent type I interferon (IFN) response resulting in upregulation of the necroptosis pathway leading to necroptotic priming. High caspase 8 expression in precursor lesions was a result of co-selection to prevent necroptosis. Hence, genetic or pharmacological targeting of caspase 8 was therapeutically highly efficacious in models of genetically engineered PDAC in vivo. These results identify type I IFN-induced necroptotic priming as synthetic lethality of KRAS-driven PDAC and show that targeting it has therapeutic benefit in this incurable malignancy.
The Growth Hormone Deficiency (GHD) Reversal Trial: Effect on final height of discontinuation versus continuation of growth hormone treatment in pubertal children with isolated GHD – A non-inferiority randomised controlled trial (RCT).
Authors: Brettell Elizabeth , Högler Wolfgang , Woolley Rebecca , Cummins Carole , Mathers Jonathan , Oppong Raymond , Roy Laura , Khan Adam , Hunt Charmaine , Dattani Mehul 
Published: July 2023

Abstract
The GHD Reversal trial is a non-inferiority RCT (ISRCTN12552768) funded by the NIHR HTA Programme (NIHR127468)
Background: Growth hormone deficiency (GHD) is the commonest endocrine cause of short stature and may occur in isolation (I-GHD) or combined with other pituitary hormone deficiencies. Around 500 children are diagnosed with GHD every year in the UK, of whom 75% have I-GHD. Growth hormone (GH) therapy improves growth in children with GHD, with the goal of achieving a normal final height (FH). GH therapy is given as daily injections until adult FH is reached. However, in many children with I-GHD their condition reverses, with a normal peak GH detected in 64-82% when re-tested at FH. Therefore, at some point between diagnosis and FH, I-GHD must have reversed, possibly due to increase in sex hormones during puberty. Despite increasing evidence for frequent I-GHD reversal, daily GH injections are traditionally continued until FH is achieved.
Methods/Design: Evidence suggests that I-GHD children who re-test normal in early puberty reach a FH comparable to that of children without GHD. The GHD Reversal study will include 138 children from routine endocrine clinics in twelve UK and five Austrian centres with I-GHD (original peak GH <6.7mcg/L) whose deficiency has reversed on early re-testing. Children will be randomised to either continue or discontinue GH therapy. This Phase III, international, multicentre, open-label, randomised controlled, non-inferiority trial (including an internal pilot study) will assess whether children with early I-GHD reversal who stop GH therapy achieve non-inferior near FH SDS (1° outcome; inferiority margin 0.55 SD), Target Height (TH) minus near FH , HRQoL, bone health index and lipid profiles (2° outcomes) than those continuing GH. In addition, the study will assess cost-effectiveness of GH discontinuation in the early retesting scenario.
Discussion: If this study shows that a significant proportion of children with presumed I-GHD reversal generate enough GH naturally in puberty to achieve a near FH within the target range, then this new care pathway would rapidly improve national/international practice. An assumed 50% reversal rate would provide potential UK health service cost savings of £1.8-4.6 Million (€2.05-5.24 Million)/year in drug costs alone. This new care pathway would also prevent children from having unnecessary daily GH injections and consequent exposure to potential adverse effects.
Oscillatory dynamics of the mammalian circadian clock induced by the core delayed negative feedback loop
Authors: Wang Conghua , Liu Haihong , Zhang Yuan 
Published: July 2023

Abstract
The mammalian circadian clock plays a crucial role in regulating the 24-hour physiological and behavioral processes. This work presents an improved model for the mammalian circadian clock by integrating physiologically plausible modifications into the Kim-Forger model, and investigates the oscillatory dynamics of the mammalian circadian clock induced by the core delayed negative feedback loop using bifurcation theory. The modifications involve introducing time delays in PER protein transcription, translation, and translocation, replacing the first-order law for PER degradation rate with the Michaelis-Menten law, and revising the transcription rate of $Per$ genes. The modified model accurately captures circadian oscillations and overcomes the unrealistic constraints of the Kim-Forger model. In addition, by utilizing the time delay as a control parameter, the theoretical results reveal that the delay induces a supercritical Hopf bifurcation, leading to the emergence of circadian oscillations with enhanced robustness, longer periods, increased amplitudes, and phase delays. Finally, numerical simulations are presented to assess the efficacy of the modified model and to validate the theoretical analysis.
Comparison of corticocancellous bone graft from the anterolateral metaphysis of the distal radius versus iliac crest for the treatment of unstable scaphoid nonunion with humpback deformity
Authors: Shin Sung-Chul , Kang Ho-Jung , Kim Nah-Yon , Lee Shin-Woo , Kim Ji-Sup 
Published: July 2023

Abstract
Background
Corticocancellous bone grafting from the iliac crest is acceptable treatment for unstable scaphoid nonunion with a viable proximal pole. However, harvesting graft from the iliac crest is associated with donor site morbidity and the requirement of general anesthesia. Thus, bone grafting from the anterolateral metaphysis of the distal radius (DR) can be a treatment option. However, no study has compared the clinical effect between the two grafting techniques.
Methods
From 2010 to 2016, patients with unstable scaphoid nonunion with humpback deformity underwent corticocancellous bone grafting from the anterolateral metaphysis of the DR (group DR) or iliac crest (group IC). Humpback deformity was determined by evaluating the scapholunate angle (SLA) ≥ 60°, intrascaphoid angle (ISA) ≥ 45°, and radiolunate angle (RLA) ≥ 15° from preoperative radiographs and computed tomography scans. The SLA, ISA, and RLA served to gauge carpal alignment. The operative time, grip strength, active range of motion (ROM), Mayo wrist score (MWS), and Disabilities of Arm, Shoulder, and Hand (DASH) score were assessed postoperatively.
Results
Thirty-eight patients qualified for the study (group DR, 15; group IC, 23). Union rates did not differ by patient subset (group DR, 100%; group IC, 95.7%; P = .827), and grip strength, ROM, MWS, and DASH score were similar between groups at the last follow-up. The operative time (minutes) was significantly shorter in group DR (median, 98; quartiles, 80, 114) than in group IC (median, 125; quartiles, 105, 150, P < .001). The ISA, RLA, and SLA improved postoperatively in both groups (P < 0.001). The degree of restoring carpal alignment, as evaluated by SLA, showed superior correction capability in group DR (median, 25.3% quartiles, 21.1, 35.3, P < 0.05). Donor site complications were not significantly different between the groups.
Conclusions
Corticocancellous bone graft from the anterolateral metaphysis of the DR for unstable scaphoid nonunion is associated with a shorter operation time and comparable results with that from the iliac crest in regard to union, restoration of carpal alignment, and wrist function.
Level of Evidence: Level III
Risk Stratification Tool for Predicting Postoperative Outcomes in Patients Undergoing Esophagectomy: A Prospective Study
Authors: YUAN Tingting , Maimaiti Mijiti , LI Dan , Ta’ati Zhaenhaer , YAN Rui 
Published: July 2023

Abstract
Purpose
Frailty, a clinical syndrome characterized by a reduced physiological reserve and decreased resistance to stressors, is extremely common in oncology patients. Given that esophagectomy is associated with significant postoperative adverse outcomes, the early identification of high-risk patients is critical. This study compared the utility of the Modified 5-Factor Frailty Index (mFI-5) and the Modified Charlson Comorbidity Index (mCCI) in predicting postoperative outcomes in patients undergoing esophagectomy.
Method
We reviewed the records of patients who underwent esophagectomy between 2019 and 2022. Two validated risk stratification tools measured the burden of comorbidity: mFI-5 and mCCI. The primary outcomes included a prolonged postoperative hospital stay and major and minor postoperative complications.
Result
A total of 359 patients were included (mean age 63.1 ± 8.6 years; 74.4% were males). The length of postoperative hospital stay was 30.0 (IQR 25.0,39.5) days, with 37 patients (10.3%) experiencing major postoperative complications and 192 patients (53.5%) experiencing minor postoperative complications. In multivariate analysis, mCCI remained a significant predictor of major postoperative complications (OR = 1.52, 95% CI 1.01–2.3, p = 0.046), but was no longer a significant predictor of prolonged postoperative hospital stay or minor complications. In addition, the mFI-5 score was no longer a significant predictor of any of the three postoperative outcomes.
Conclusion
This is the first study to compare the utility of the mFI-5 and mCCI in predicting adverse postoperative outcomes in patients undergoing esophagectomy. Our findings suggest that mCCI is a valid predictor of major complications in this patient group, whereas the role of mFI-5 is limited. This should be further investigated in a prospective multicenter cohort study.
The role of specific isoforms of CaV2 and the common C-terminal of CaV2 in calcium channel function in sensory neurons of Aplysia
Authors: Dunn Tyler W , Fan Xiaotang , Lee Jiwon , Smith Petranea , Gandhi Rushali , Sossin Wayne S 
Published: July 2023

Abstract
Habituation is the diminishing of a physiological response to a frequently repeated stimulus. In Aplysia, habituation to touch is mediated by the depression of the response to sensory neuron firing mediated by a decrease in transmitter release even after modest rates of action potential firing. This depression is not common among Aplysia synaptic connections suggesting the presence of a release apparatus specialized for this depression. This depression can be reversed through activation of protein kinase C and this is thought to underlie the behavior of dishabituation. We have previously noted that the calcium channel required for release, ApCaV2, has many splice isoforms in Aplysia. We found that specific splice forms of ApCaV2 and splice forms for interacting partners of ApCaV2 are preferentially used in sensory neurons, consistent with a specialized release apparatus. However, we were not able to find a specific splice uniquely required for synaptic depression. The C-terminus of ApCaV2 alpha1 subunit retains conserved binding sites for Aplysia rab-3 interacting molecule (ApRIM) and ApRIM-binding protein (ApRBP) and the C-terminus is required for full synaptic expression of ApCaV2.
Efficacy of ultrasound-guided stellate ganglion block on relieving acute postoperative pain: systematic review and meta-analysis
Authors: Zhao Yan , Xiao Xiangli 
Published: July 2023

Abstract

Background
The efficacy of stellate ganglion block (SGB) in alleviating postoperative pain remains uncertain. This meta-analysis aimed to determine the efficacy of ultrasound-guided SGB in relieving acute postoperative pain in patients undergoing surgery with general anesthesia.
Methods
A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted comparing SGB with control or placebo. The primary outcome was pain score at 24h after surgery. Secondly outcomes included postoperative pain scores at other times (0, 2, 4, 6, 8, 12h) and postoperative nausea and vomiting. A random effects model was used to calculate mean difference (MD) or risk ratio (RR) with 95% confidence intervals.
Results
Eight studies, with a total of 470 patients, were included in this meta-analysis. Ultrasound-guided SGB was associated with lower pain score at 24h after surgery (MD − 0.71; 95% CI: −1.26, − 0.16, p = 0.01, I2 = 86%), with low level of evidence. Ultrasound-guided SGB was also linked to a lower pain score at postoperative 8h (MD − 0.65; 95% CI: −1.03, − 0.28, p = 0.01, I2 = 29%), with moderate level of evidence. There was no difference in pain scores at 0, 2, 4, 6,12 hours after surgery.
Conclusion
Ultrasound-guided SGB is effective in alleviating acute postoperative pain. However, given the low level of evidence and a limited number of trials, more large-scale and high-quality RCTs are required in the future researches.