bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moxifloxacin monotherapy for treatment of uncomplicated pelvic inflammatory disease: A systematic review and meta‐analysis with trial sequential analysis of randomized controlled trials
Authors: Chen Feng , Dong Qin , Hong Weilan , Zhao Jing , Li Yingran 
Published: September 2023

AbstractPurposeThe aim of this study was to evaluate the efficacy and safety of moxifloxacin monotherapy for the treatment of uncomplicated pelvic inflammatory disease (uPID).MethodsThe literatures from PubMed, ScienceDirect, Google Scholar, Cochrane library and the http://clinicaltrials.gov/ were retrieved until February 2023. Only randomized controlled trials (RCTs) comparing the efficacy and safety of moxifloxacin with other antibiotics for treating uPID were included. The primary outcomes were clinical cure rate (CCR), bacteriological success rates (BSR) and risk of drug‐related adverse events (AEs). We used random‐effects modelled meta‐analysis, trial sequential analysis, and the Grading of Recommendations Assessment, Development, and Evaluation. This study was registered in the International Prospective Register of Systematic Reviews (registration number: CRD42023428751).ResultsA total of four RCTs that enrolled 3201 women patients with uPID were included. In the per‐protocol populations, no significant difference was observed between patients given moxifloxacin and those given other antibiotics with regard to CCR at test‐of‐cure (TOC) (2485 patients, odds ratio [OR] = 0.84, 95% confidence interval [CI] 0.68–1.04, p = 0.12). Similarly, there was no statistically significant difference between patients given moxifloxacin and those given other antibiotics in terms of BSR at TOC (471 patients, OR = 1.17, 95% CI 0.70–1.96, p = 0.56) in the microbiologically valid population. However, drug‐related AEs occurred less frequently with moxifloxacin than with other antibiotics (2973 patients, OR = 0.74, 95% CI 0.64–0.86, p < 0.0001), especially gastrointestinal AEs (2973 patients, OR = 0.59, 95% CI 0.47–0.74, p < 0.00001).ConclusionsIn the treatment of uPID, moxifloxacin monotherapy can achieve similar efficacy as other combination therapy regimens. Moreover, moxifloxacin had a better safety profile than that of comparators. Based on its additional advantages (i.e., better safety profile, no dosage adjustment and better compliance), moxifloxacin may be a more fascinating option compared with the currently used regimens.
Ensuring permanence of optics for ultrafast laser applications
Authors: Ceizaris Lukas , Batavičiūtė Gintarė 
Published: September 2023

AbstractUltrafast lasers in various applications suffer from short lifetime optics due to high power levels and intense pulses. Typical laser damage testing methods are often limited to short exposure doses, which sometimes do not match real‐life application requirements. To ensure long‐term failure‐free operation, lifetime estimation and low‐loss absorptance testing should be used instead. Low‐absorption dielectric coatings increase the lifetime and lower the total cost of ownership, benefiting the manufacturing, research, and medical sectors.
Cover Image
Authors: Phetsuk Sawarot , Molloy Robert , Topham Paul D , Tighe Brian J , Meepowpan Puttinan , Limwanich Wanich , Punyodom Winita 
Published: September 2023

AbstractThe cover image is based on the Research Article Use of non‐isothermal DSC in comparative studies of tin(II) systems for the ring‐opening polymerization of D‐lactide by Sawarot Phetsuk et al., https://doi.org/10.1002/pi.6517.
image
Longitudinal trajectories of children's social skills: Examining variability in teacher ratings as a function of child demographics
Authors: Hajovsky Daniel B. , Chesnut Steven R. , Sekula Morgan K. , Olsen Sunny 
Published: September 2023

AbstractAlthough the trajectories of children's social skills have been examined across biological sexes, less research has examined these patterns for racially and ethnically diverse children in the United States. The purpose of this study was to estimate the longitudinal growth trajectories of social skills, while examining the influence of biological sex, race, and ethnic identities using an adaptation of the commonly used Social Skills Rating Scale. A large nationally representative sample of elementary school children in the United States were assessed annually from kindergarten through fifth grade (N = 11,792). Structural equation modeling was used to examine latent growth curve models of teacher‐rated interpersonal skills and self‐control. After finding evidence of longitudinal invariance, results suggested a quadratic growth pattern best represented the trajectories of social skills ratings. Teacher ratings for African American children demonstrated a moderate declining linear trajectory throughout elementary school when compared with White children (reference group) and their Asian and Hispanic peers. Children from families with higher socioeconomic status and girls showed moderate to large differences in social skills ratings in kindergarten and stronger growth across time. Implications of the findings with future directions for research are discussed.
Antifungal activity of Ligusticum chuanxiong essential oil and its active composition butylidenephthalide against Sclerotium rolfsii
Authors: Cui Kaidi , He Ya , Wang Mengke , Li Min , Jiang Chaofan , Wang Meizi , He Leiming , Zhang Fulong , Zhou Lin 
Published: September 2023

AbstractBACKGROUNDPeanut stem rot caused by Sclerotium rolfsii is an epidemic disastrous soil‐borne disease. Recently, natural products tend to be safe alternative antifungal agents to combat pathogens.RESULTSThis work determined the preliminary antifungal activity of 29 essential oils against S. rolfsii and found that Ligusticum chuanxiong essential oil (LCEO) showed the best antifungal activity, with an EC50 value of 81.79 mg L−1. Sixteen components (98.78%) were identified in LCEO by gas chromatography‐mass spectrometry analysis, the majority by volume comprising five phthalides (93.14%). Among these five phthalides, butylidenephthalide was the most effective compound against S. rolfsii. Butylidenephthalide not only exhibited favorable in vitro antifungal activity against the mycelial growth, sclerotia production and germination of S. rolfsi, but also presented efficient in vivo efficacy in the control of peanut stem rot. Seven days after application in the glasshouse, the protective and curative efficacy of butylidenephthalide at 300 mg L−1 (52.02%, 44.88%) and LCEO at 1000 mg L−1 (49.60%, 44.29%) against S. rolfsii were similar to that of the reference fungicide polyoxin at 300 mg L−1 (54.61%, 48.28%). Butylidenephthalide also significantly decreased the oxalic acid and polygalacturonase content of S. rolfsii, suggesting a decreased infection ability on plants. Results of biochemical actions indicated that butylidenephthalide did not have any effect on the cell membrane integrity and permeability but significantly decreased nutrient contents, disrupted the mitochondrial membrane, inhibited energy metabolism and induced reactive oxygen species (ROS) accumulation of S. rolfsii.CONCLUSIONOur results could provide an important reference for understanding the application potential and mechanisms of butylidenephthalide in the control of S. rolfsii. © 2023 Society of Chemical Industry.
Mid‐dosing interval concentration is important for polymyxin B exposure and acute kidney injury in critically ill patients
Authors: Wang Jing , Li Yuanchen , Huang Siqi , Wang Min , Jin Lu , Luo Xuemei , Cheng Xiaoliang , Yang Na , Zhu Huaijun 
Published: September 2023

AbstractThis study aimed to evaluate the association between polymyxin B (PMB) exposure and acute kidney injury (AKI) and analyze the risk factors for PMB‐induced AKI in critically ill patients. Plasma concentrations of PMB were determined using an ultraperformance liquid chromatography–tandem mass spectrometer in intensive care unit patients who were administered PMB. Univariate and multivariate analyses were conducted to identify risk factors. A receiver operating characteristic curve was constructed to assess the discriminant power of the factors and to identify the cutoff value for AKI. The white blood cell count and estimated area under the concentration–time curve (AUC) of patients administered PMB were independent risk factors for PMB‐induced AKI, where AUC were calculated using a first‐order pharmacokinetic equation based on the mid‐dosing interval concentration (C1/2t) and peak concentration. The area under the receiver operating characteristic curve of the final model was 0.805 (95% confidence interval, 0.690–0.921). The cutoff value for the combined predictor was 0.57. Alternatively, when using C1/2t, which was strongly correlated with AUC, as the only independent risk factor, the analysis showed that the 3.47 μg/ml threshold provides favorable differentiation between the AKI and non‐AKI groups. These results provide insightful information for therapeutic drug monitoring–guiding PMB dosing in clinical practice.
Iterative learning consensus control for one‐sided Lipschitz multi‐agent systems
Authors: Gu Panpan , Wang Hong , Chen Liping , Chu Zhaobi , Tian Senping 
Published: September 2023

AbstractBy applying iterative learning control approach, the consensus is studied for multi‐agent systems (MASs) with one‐sided Lipschitz (OSL) nonlinearity. Firstly, the P‐type and D‐type learning schemes with initial state learning are introduced for such MASs. Then, utilizing the OSL and the quadratically inner‐bounded constraints, the convergence conditions of the consensus algorithms are presented and analyzed under a directed communication graph. We show that both algorithms, on a fixed finite‐time interval, can achieve perfect consensus tracking. Finally, the correctness of the obtained results is illustrated with simulation examples.
A Bacterial Nanomedicine Combines Photodynamic‐Immunotherapy and Chemotherapy for Enhanced Treatment of Oral Squamous Cell Carcinoma
Authors: Shi Enyu , Shan Tianhe , Wang Hanping , Mao Lujia , Liang Yanjie , Cao Mingxin , Wu Qiqi , Li Changyi , Wang Yue , Wang Yinsong 
Published: September 2023

AbstractBacterial therapy is an emerging hotspot in tumor immunotherapy, which can initiate antitumor immune activation through multiple mechanisms. Porphyromonas gingivalis (Pg), a pathogenic bacterium inhabiting the oral cavity, contains a great deal of pathogen associated molecular patterns that can activate various innate immune cells to promote antitumor immunity. Owing to the presence of protoporphyrin IX (PpIX), Pg is also an excellent photosensitizer for photodynamic therapy (PDT) via the in situ generation of reactive oxygen species. This study reports a bacterial nanomedicine (nmPg) fabricated from Pg through lysozyme degradation, ammonium chloride lysis, and nanoextrusion, which has potent PDT and immune activation performances for oral squamous cell carcinoma (OSCC) treatment. To further promote the tumoricidal efficacy, a commonly used chemotherapeutic drug doxorubicin (DOX) is efficiently encapsulated into nmPg through a simple incubation method. nmPg/DOX thus prepared exhibits significant synergistic effects on inhibiting the growth and metastasis of OSCC both in vitro and in vivo via photodynamic‐immunotherapy and chemotherapy. In summary, this work develops a promising bacterial nanomedicine for enhanced treatment of OSCC.
Prevalence and incidence of canine visceral leishmaniasis and its clinical–immunological features in an endemic area of the Brazilian Amazon
Authors: Carneiro Liliane A. , Lima Luciana V. , Campos Marliane B. , Vasconcelos dos Santos Thiago , Ramos Patrícia K. , Laurenti Márcia D. , Silveira Fernando T. 
Published: September 2023

AbstractBackgroundA cohort study for 2 years period analysed the prevalence, incidence and clinical–immunological features of canine Leishmania (L.) chagasi‐infection in 316 mongrel dogs in a visceral leishmaniasis‐endemic area in Pará State, Brazil.Objective/MethodsDiagnosis of infection was performed by the indirect fluorescent antibody test (IFAT‐IgG), the leishmanin skin test (LST) and a parasite search (from the popliteal lymph node aspiration) at the beginning of the study and at 6, 12 and 24 months intervals.ResultsIFAT/LST revealed three immune profiles of infection: (I) IFAT(+)/LST(−) (81), (II) IFAT(−)/LST(+) (17) and (III) IFAT(+)/LST(+) (13). Prevalence of profiles I, II and III were 25.6, 5.4 and 4.1%, and an overall prevalence 35.1%. Incidence of profiles I, II and III were 5.4, 0.3 and 0.0%, and an overall incidence 5.7% dogs per month. Incidence at the age ranges <1 year, ≥1 year, <7 years and ≥7 years evidenced a highest rate in the age range <1 year (6.6% dogs per month). Parasitological diagnosis was positive in 19% dogs at the prevalence (85.7% profile I), and in 11% at the incidence (100% profile I). The clinical picture of 179 infected dogs showed 145 (81%) of profile I (82% subclinical); 21 (11.7%) of profile II (100% subclinical); and 13 (7.3%) of profile III (84.6% subclinical). Conversion from subclinical to sick dogs was higher (p < 0.05) in profile I (40.2%) than in profiles II (5.8%) and III (9%). Immunological conversion showed that only 3.2% of profile I dogs (prevalence) converted to LST(+) (two at the end of the first 6 months and 1 after 24 months), while 82.3% of profile II dogs converted to IFAT(+) (11 in the first 6 months, whereas three after 12 months). A 100% death rate was observed in dogs from profile I alone.ConclusionThese results reinforce the need of adopting preventive strategies against CVL as early as in the first semester of the dog's life.
Rangeland Songbirds
Authors: Chalfoun Anna D. , Johnson Tracey N. , Shaffer Jill A. 
Published: September 2023

AbstractSongbirds that occur across the diverse types of North American rangelands constitute many families within the Order Passeriformes, and hundreds of species. Most are declining, and many are considered potential indicator species for rangeland ecosystems. We synthesized information on the natural and life history, habitat requirements, conservation status, and responses to management of songbirds associated with North American grasslands and sagebrush steppe, two of the most geographically extensive types of rangelands. We provide a more targeted examination of the habitat associations and management considerations for two focal species, the grassland-obligate grasshopper sparrow (Ammodramus savannarum) and sagebrush-obligate Brewer’s sparrow (Spizella breweri). Grassland- and sagebrush-obligate species rely on expansive stands of grasslands and sagebrush, respectively, and we discuss how key ecological processes and rangeland management approaches—grazing, fire, and mechanical treatments—influence rangeland songbirds. Rangeland management practices can affect breeding songbirds considerably, primarily through the resultant structure and composition of vegetation, which influences the availability of preferred nesting substrates, refugia from predators, and foraging success. Optimal management strategies to limit negative consequences to rangeland songbirds will depend on the target species and local topoedaphic and climatic conditions. The maintenance of large, contiguous patches of native habitats and restoration of previously degraded areas will help facilitate the population persistence of rangeland-associated songbirds. Maintaining structural heterogeneity of habitats within landscapes, moreover, can facilitate local species diversity. Information pertaining to periods outside of the nesting stage is severely lacking for most species, which is concerning because effective management necessitates understanding of threats and limiting factors across the full annual life cycle. Moreover, information on disease effects and prevalence, the effects of a changing climate, and how both may interact with management strategies, also comprise key gaps in knowledge.
Amphibians and Reptiles
Authors: Pilliod David S. , Esque Todd C. 
Published: September 2023

AbstractAmphibians and reptiles are a diverse group of ectothermic vertebrates that occupy a variety of habitats in rangelands of North America, from wetlands to the driest deserts. These two classes of vertebrates are often referred to as herpetofauna and are studied under the field of herpetology. In U.S. rangelands, there are approximately 66 species of frogs and toads, 58 salamanders, 98 lizards, 111 snakes, and 27 turtles and tortoises. Herpetofauna tend to be poorly studied compared with other vertebrates, which creates a challenge for biologists and landowners who are trying to manage rangeland activities for this diverse group of animals and their habitats. Degradation of habitats from human land use and alteration of natural processes, like wildfire, are primary threats to herpetofauna populations. Disease, non-native predators, collection for the pet trade, and persecution are also conservation concerns for some species. Properly managed livestock grazing is generally compatible with herpetofauna conservation, and private and public rangelands provide crucial habitat for many species. Climate change also poses a threat to herpetofauna, but we have an incomplete understanding of the potential effects on species. Dispersal and adaptation could provide some capacity for species to persist on rangelands as climates, disturbance regimes, and habitats change. However, inadequate information and considerable uncertainty will make climate mitigation planning difficult for the foreseeable future. Planning for and mitigating effects of climate change, and interactions with other stressors, is an urgent area for research. Maintaining large, heterogeneous land areas as rangelands will certainly be an important part of the conservation strategy for herpetofauna in North America.
The Future of Rangeland Wildlife Conservation—Synopsis
Authors: Dahlgren David K. , McNew Lance B. , Beck Jeffrey L. 
Published: September 2023

AbstractRangeland Wildlife Ecology and Conservation provides a broad array of information on rangeland ecology in association with rangeland-dependent wildlife species. Management of land-use practices from livestock grazing to vegetation manipulation are addressed, as well as ecosystem threats that put the future of rangeland-wildlife at risk. Large-scale pervasive issues, such as climate change and land-use alterations, increase uncertainty for the future of our rangeland resources. Ecosystem services that are essential to sustaining human life may be the most concerning issue as we continue to face further resource degradation. However, such concerns could provide the impetus for general societal support of future conservation actions. Our book addresses emerging topics, such as the interaction of rangelands with riparian habitat, biodiversity, insects, wetland birds, herpetofauna, meso- and large carnivores, and avian predators, subjects that have previously received less attention in relation to rangeland ecosystems. Future conservation of rangeland-wildlife will require more integration from the rangeland and wildlife professions, from academic efforts to individual practitioners. The objective of Rangeland Wildlife Ecology and Conservation is to provide a valuable information resource and encourage increased integration for students and early professionals from both disciplines.
Rangeland Biodiversity
Authors: Hovick Torre J. , Duchardt Courtney J. , Duquette Cameron A. 
Published: September 2023

AbstractIn its simplest form, biodiversity is defined as species richness (the number of species in a given area). More complex definitions include the variety of life on Earth, from genes to ecosystems, and include the ecological and evolutionary processes that sustain that life. As in other ecosystems, biological communities in rangelands are influenced by a number of different abiotic and biotic drivers or “filters” at both broad and fine scales, and an understanding of these processes is critical for maintaining ecosystem services as well as addressing widespread biodiversity declines. In rangeland ecosystems specifically, the primary threats to biodiversity are habitat loss, fragmentation, and degradation through mismanagement, which includes suppression or mis-application of historical disturbance regimes. Restoring heterogeneity to rangelands by mimicking historical disturbance regimes has been shown to benefit biodiversity, but the exact role of disturbance varies widely throughout North American rangelands. As such, careful consideration of the type, duration/periodicity, intensity, and spatial and temporal extent and configuration of these disturbances is necessary when managing for site-specific biodiversity outcomes. It is important to consider the effects of both inherent (i.e., either natural or historical) and human-caused variability on rangeland plant and wildlife communities. In the future, practitioners should promote management practices that maintain and enhance biodiversity to maximize ecosystem functions and services that improve the quality and quantity of economic (e.g., livestock production, carbon banking) and ecological (e.g., biodiversity, sustainability) outcomes in North American rangelands.
A Theory of Cartesian Arrays (with Applications in Quantum Circuit Verification)
Authors: Chen Yu-Fang , Rümmer Philipp , Tsai Wei-Lun 
Published: September 2023

AbstractWe present a theory of Cartesian arrays, which are multi-dimensional arrays with support for the projection of arrays to sub-arrays, as well as for updating sub-arrays. The resulting logic is an extension of Combinatorial Array Logic (CAL) and is motivated by the analysis of quantum circuits: using projection, we can succinctly encode the semantics of quantum gates as quantifier-free formulas and verify the end-to-end correctness of quantum circuits. Since the logic is expressive enough to represent quantum circuits succinctly, it necessarily has a high complexity; as we show, it suffices to encode thek-color problem of a graph under a succinct circuit representation, an NEXPTIME-complete problem. We present an NEXPTIME decision procedure for the logic and report on preliminary experiments with the analysis of quantum circuits using this decision procedure.
SAT-Based Subsumption Resolution
Authors: Coutelier Robin , Kovács Laura , Rawson Michael , Rath Jakob 
Published: September 2023

AbstractSubsumption resolution is an expensive but highly effective simplifying inference for first-order saturation theorem provers. We present a new SAT-based reasoning technique for subsumption resolution, without requiring radical changes to the underlying saturation algorithm. We implemented our work in the theorem proverVampire, and show that it is noticeably faster than the state of the art.
Proving Non-Termination by Acceleration Driven Clause Learning (Short Paper)
Authors: Frohn Florian , Giesl Jürgen 
Published: September 2023

AbstractWe recently proposed Acceleration Driven Clause Learning (ADCL), a novel calculus to analyze satisfiability of Constrained Horn Clauses (CHCs). Here, we adapt ADCL to transition systems and introduce ADCL-NT, a variant for disproving termination. We implemented ADCL-NT in our tool and evaluate it against the state of the art.