bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybrid shielding structure for reduction of the leakage magnetic field in wireless power transfer system
Authors: Kim Jongchan , Jeong Minjoo , Hong Icpyo , Rhee Seungyeop , Cho Inkui , Kim Nam 
Published: September 2023

AbstractIn this paper, we propose a hybrid shielding structure for the reduction of the leakage magnetic field in the wireless power transfer (WPT) system operating at 175 kHz. This structure consists of ferrite slab staked on the aluminum plate. The improvement in the magnetic field reduction is achieved, while minimizing the power transfer loss by optimizing the design parameters. The power transfer efficiency and leakage magnetic field are analyzed and verified through simulation and experiment. The experimental results show 77% power transfer efficiency with proposed structure, while the normalized leakage magnetic field strength was reduced up to 80% compared with the conventional shielding structures.
Ultra‐compact, four‐port antenna for ATSC‐TV indoor reception
Authors: Haskou Abdullah , Pesin Anthony , Le Naour Jean‐Yves , Louzir Ali 
Published: September 2023

AbstractIn this letter, an ultra‐compact, wide‐band, four‐port antenna, integrated within the ATSC receiver housing for indoor reception of TV broadcast is presented. The four ports with moderate directivity are used to attenuate interferences and mitigate indoor multipath fading. The antenna hybrid topology is inspired from the Annular Slot Antenna (ASA) and the wide band printed monopole. The antenna is printed on an FR4 substrate with total dimensions of 280 × 280 × 1.2 mm3. It covers both high‐VHF and UHF TV broadcast bands in the US, with an S11 < ‐6 dB and a mean total efficiency of 18.5% in the VHF band and a S11 < ‐10 dB and a mean total efficiency of 52.9% in the UHF band. By switching between the four beams, a very good omni‐directional coverage is achieved in the horizontal plane. The antenna simulated performances are thoroughly analyzed and validated via measurements. The antenna was also integrated in a product and system tests for the indoor reception of TV broadcast in real field conditions revealed very promising performances.
Dual mode grating sensor using microring conjugate mirror and plasmonic island
Authors: Pornsuwancharoen Nithiroth , Jalil Muhammad Arif , Amiri Iraj S. , Ali Jalil , Yupapin Preecha 
Published: September 2023

AbstractIn this study, we propose a model for the dual mode gold grating sensor using a microring conjugate mirror (MCM) and the plasmonic island. The sensor measurement of derived quantity is the change in the Bragg wavelength and electron mobility that can be related to the optical phase‐shift or gold grating mobility changes. The plasmonic island consists of the stacked layers of silicon‐graphene‐gold materials. At the resonant condition, the gold electron mobility is driven by the whispering gallery mode generated by the nonlinear microring resonator. Additionally, the 3D reflection power profile of the grating sensor and target source interaction can be formed by the MCM. By selecting the suitable parameters, it can be arranged to have the four‐wave mixing output, which is the criterion of the 3D output of the MRC. The calculation results have shown that there is a relationship between the change in the electron mobility and Bragg wavelength of
~1.5 × 10−21 cm2 V−1 s−1 (mW)−1 at the
λ
Bragg of 1.55 μm, where the separation of 1 nm is obtained. The related mathematical formulas are re‐arranged for suitable applications.
Phase 1 study of cabozantinib in combination with topotecan–cyclophosphamide for patients with relapsed Ewing sarcoma or osteosarcoma
Authors: Campbell Kevin , Posner Andrew , Chen Nan , Cavanaugh Kerri , Bhushan Ketki , Janeway Katherine A. , Shulman David S. , George Suzanne , Klega Kelly , Crompton Brian , London Wendy B. , DuBois Steven G. 
Published: September 2023

AbstractPurposePhase 1 study assessing the safety and toxicity of cabozantinib in combination with topotecan and cyclophosphamide for relapsed osteosarcoma and Ewing sarcoma.MethodsOral cabozantinib (25 mg/m2) was administered daily for 21 (dose level 1) or 14 (dose level −1B) days. Topotecan (0.75 mg/m2) and cyclophosphamide (250 mg/m2) were administered intravenously (IV) on days 1–5. A modified 3+3 design based upon first cycle dose‐limiting toxicities (DLT) was used for dose escalation.ResultsTwelve patients with a median age of 15 (12.9–33.2) years were enrolled (seven with Ewing sarcoma; five with osteosarcoma); all were evaluable for toxicity. At dose level 1, three of six patients developed first cycle DLT: grade 3 epistaxis, grade 3 transaminitis, and prolonged grade 2 thrombocytopenia. Six patients were enrolled on dose level −1B (interrupted cabozantinib, given days 8–21), with one first cycle DLT (grade 3 pneumothorax) observed. Of the 10 response evaluable patients, one had partial response (Ewing sarcoma), seven had stable disease, and two had progressive disease.ConclusionsThe recommended phase 2 doses and schedules for this combination are topotecan 0.75 mg/m2 IV days 1–5, cyclophosphamide 250 mg/m2 IV days 1–5, and cabozantinib 25 mg/m2 days 8–21. Non‐concomitant administration of cabozantinib with cytotoxic therapy in this population has acceptable toxicity, while allowing for potential disease control.
Investigation of in vitro generated metabolites of LGD‐4033, a selective androgen receptor modulator, in homogenized camel liver for anti‐doping applications
Authors: Ondern Komathu Praseen , Padusha Mohamed Khan Syed Ali , Laya Saraswathy , Nalakath Jahfar , Palathinkal Ansar Babu , Nelliyott Ibrahimwaseem 
Published: September 2023

RationaleThe use of selective androgen receptor modulators (SARM) in sports is prohibited by the World Anti‐Doping Agency (WADA) due to their potential as performance‐enhancing drugs, offering an unfair advantage. LGD‐4033 is a SARM known for its similarities to anabolic steroids and can be easily purchased online, leading to increased availability and misuse. Adverse analytical findings have revealed the presence of SARMs in dietary supplements. Although LGD‐4033 misuse has been reported in human sports over the years, concerns also arise regarding its illicit use in animal sports, including camel racing. Although various studies have investigated the metabolism of LGD‐4033 in humans, horse, and other species, there is limited research specifically dedicated to racing camels.MethodsThis study focuses on the in vitro metabolism of LGD‐4033 in homogenized camel liver using liquid chromatography–high‐resolution mass spectrometry (LC‐HRMS) to identify and characterize the metabolites.ResultsThe findings indicated the presence of 12 phase I metabolites and 1 phase II metabolite. Hydroxylation was responsible for the formation of the main phase I metabolites that were identified. A glucuronic acid conjugate of the parent drug was observed in this study, but no sulfonic acid conjugate was found. The possible chemical structures of these metabolites, along with their fragmentation patterns, were identified using MS.ConclusionsThese findings provide valuable insights into the metabolism of LGD‐4033 in camels and aid in the development of effective doping control methods for the detection of SARMs in camel racing.
Identification of raffinose family oligosaccharides in processed Rehmannia glutinosa Libosch using matrix‐assisted laser desorption/ionization mass spectrometry image combined with machine learning
Authors: Li Huizhi , Zhang Shishan , Zhao Yanfang , He Jixiang , Chen Xiangfeng 
Published: September 2023

RationaleCurrently, research on oligosaccharides primarily focuses on the physiological activity and function, with a few studies elaborating on the spatial distribution characterization and variation in the processing of Rehmannia glutinosa Libosch. Thus, imaging the spatial distributions and dynamic changes in oligosaccharides during the steaming process is significant for characterizing the metabolic networks of R. glutinosa. It will be beneficial to characterize the impact of steaming on the active ingredients and distribution patterns in different parts of the plant.MethodsA highly sensitive matrix‐assisted laser desorption/ionization mass spectrometry image (MALDI‐MSI) method was used to visualize the spatial distribution of oligosaccharides in processed R. glutinosa. Furthermore, machine learning was used to distinguish the processed R. glutinosa samples obtained under different steaming conditions.ResultsImaging results showed that the oligosaccharides in the fresh R. glutinosa were mainly distributed in the cortex and xylem. As steaming progressed, the tetra‐ and pentasaccharides were hydrolyzed and diffused gradually into the tissue section. MALDI‐MS profiling combined with machine learning was used to identify the processed R. glutinosa samples accurately at different steaming intervals. Eight algorithms were used to build classification machine learning models, which were evaluated for accuracy, precision, recall, and F1 score. The linear discriminant analysis and random forest models performed the best, with prediction accuracies of 0.98 and 0.97, respectively, and thus can be considered for identifying the steaming durations of R. glutinosa.ConclusionsMALDI‐MSI combined with machine learning can be used to visualize the distribution of oligosaccharides and identify the processed samples after steaming for different durations. This can enhance our understanding of the metabolic changes that occur during the steaming process of R. glutinosa; meanwhile, it is expected to provide a theoretical reference for the standardization and modernization of processing in the field of medicinal plants.
Realization of High Magnetization in Artificially Designed Ni/NiO Layers through Exchange Coupling
Authors: Ding Xiang , Cui Xiangyuan , Tseng Li‐Ting , Wang Yiren , Qu Jiangtao , Yue Zengji , Sang Lina , Lee Wai Tung , Guan Xinwei , Bao Nina , Sathish CI , Yu Xiaojiang , Xi Shibo , Breese Mark B.H. , Zheng Rongkun , Wang Xiaolin , Wang Lan , Wu Tom , Ding Jun , Vinu Ajayan , Ringer Simon P. , Yi Jiabao 
Published: September 2023

AbstractHigh‐magnetization materials play crucial roles in various applications. However, the past few decades have witnessed a stagnation in the discovery of new materials with high magnetization. In this work, Ni/NiO nanocomposites are fabricated by depositing Ni and NiO thin layers alternately, followed by annealing at specific temperatures. Both the as‐deposited samples and those annealed at 373 K exhibit low magnetization. However, the samples annealed at 473 K exhibit a significantly enhanced saturation magnetization exceeding 607 emu cm−3 at room temperature, surpassing that of pure Ni (480 emu cm−3). Material characterizations indicate that the composite comprises NiO nanoclusters of size 1–2 nm embedded in the Ni matrix. This nanoclustered NiO is primarily responsible for the high magnetization, as confirmed by density functional theory calculations. The calculations also indicate that the NiO clusters are ferromagnetically coupled with Ni, resulting in enhanced magnetization. This work demonstrates a new route toward developing artificial high‐magnetization materials using the high magnetic moments of nanoclustered antiferromagnetic materials.
Hierarchical NiCo@NiOOH@CoMoO4 Core–Shell Heterostructure on Carbon Cloth for High‐Performance Asymmetric Supercapacitors
Authors: Akbar Abdul Rehman , Peng Gangqiang , Li Yongyi , Iqbal Rashid , Saleem Adil , Wang Guohong , Khan Abdul Sammed , Ali Mumtaz , Tahir Muhammad , Assiri Mohammed A. , Ali Ghaffar , Liu Fude 
Published: September 2023

AbstractThe fabrication of low‐cost, effective, and highly integrated nanostructured materials through simple and reproducible methods for high‐energy‐density supercapacitors is highly desirable. Herein, an activated carbon cloth (ACC) is designed as the functional scaffold for supercapacitors and treated hydrothermally to deposit NiCo nanoneedles working as internal core, followed by a dip‐dry coating of NiOOH nanoflakes core–shell and uniform hydrothermal deposition of CoMoO4 nanosheets serving as an external shell. The structured core–shell heterostructure ACC@NiCo@NiOOH@CoMoO4 electrode resulted in exceptional specific areal capacitance of 2920 mF cm−2 and exceptional cycling stability for 10 000 cycles. Moreover, the fabricated electrode is developed into an asymmetric supercapacitor which demonstrates excellent areal capacitance, energy density, and power density within the broad potential window of 1.7 V with a cycling life of 92.4% after 10 000 charge–discharge cycles, which reflects excellent cycle life. The distinctive core–shell structure, highly conductive substrate, and synergetic effect of coated material results in more electrochemical active sites and flanges for effective electrons and ion transportation. This unique technique provides a new perspective for cost‐efficient supercapacitor applications.
Transforming Spirulina maxima Biomass into Ultrathin Bioactive Coatings Using an Atmospheric Plasma Jet: A New Approach to Healing of Infected Wounds
Authors: Pham Tuyet , Nguyen Tien Thanh , Nguyen Ngoc Huu , Hayles Andrew , Li Wenshao , Pham Duy Quang , Nguyen Chung Kim , Nguyen Trung , Vongsvivut Jitraporn , Ninan Neethu , Sabri Ylias , Zhang Wei , Vasilev Krasimir , Truong Vi Khanh 
Published: September 2023

AbstractThe challenge of wound healing, particularly in patients with comorbidities such as diabetes, is intensified by wound infection and the accelerating problem of bacterial resistance to current remedies such as antibiotics and silver. One promising approach harnesses the bioactive and antibacterial compound C‐phycocyanin from the microalga Spirulina maxima. However, the current processes of extracting this compound and developing coatings are unsustainable and difficult to achieve. To circumvent these obstacles, a novel, sustainable argon atmospheric plasma jet (Ar‐APJ) technology that transforms S. maxima biomass into bioactive coatings is presented. This Ar‐APJ can selectively disrupt the cell walls of S. maxima, converting them into bioactive ultrathin coatings, which are found to be durable under aqueous conditions. The findings demonstrate that Ar‐APJ‐transformed bioactive coatings show better antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Moreover, these coatings exhibit compatibility with macrophages, induce an anti‐inflammatory response by reducing interleukin 6 production, and promote cell migration in keratinocytes. This study offers an innovative, single‐step, sustainable technology for transforming microalgae into bioactive coatings. The approach reported here has immense potential for the generation of bioactive coatings for combating wound infections and may offer a significant advance in wound care research and application.
High‐performance extended actors
Authors: Buhr Peter A. , Parsons Colby A. , Delisle Thierry , Li He Nan 
Published: September 2023

AbstractActors are a popular mechanism for indirectly expressing concurrency. This article examines an implementation in the concurrent dialect of C++, C++, which runs actors on shared‐memory multi‐processor computers. The C++ actor system targets 32–256+ multi‐core shared‐memory computers that form the backbone of high‐performance computing, rather than distributed actor communication or robust execution via parentage fallback used by other actor systems. Five new mechanisms are presented to achieve expressibility, robustness, high performance, and scalability of actor applications across multiple cores: explicit life time (storage management) of actors and messages, combining actors and coroutines, a forward message‐trace and backward message‐return for debugging and failures, a new promise call‐back for ask sends, and an actor implementation that inverts the actor execution‐model by decoupling actor mailboxes with high levels of sharding. Microbenchmarks compare the new actor features with CAF, Protoactor, and classic and typed Akka.
Demographic and genetic consequences of a steelhead supplementation program
Authors: Smith Christian T. , Headley Racheal , Smith Matt , Kennedy Benjamen M. , Holmes John , Nehmens Melissa , Adams Brice , Piteo Matthew , Von Bargen Jennifer 
Published: September 2023

Abstract

Objective
Supplementation of naturally spawning populations by the addition of hatchery-spawned individuals is commonly conducted for recovery of threatened and endangered populations and to support harvest opportunities. Our objective was to evaluate whether the use of a juvenile captive broodstock and an integrated paradigm could increase returns of steelhead, the anadromous form of Rainbow Trout Oncorhynchus mykiss, while avoiding negative genetic impacts commonly associated with hatchery propagation.

Methods
We analyzed 291 genetic markers in adult steelhead returning to an integrated population in southwest Washington over the course of 15 years. Reproductive success (RS) of fish spawning in the natural environment was evaluated by origin (hatchery versus natural) and return year. Data were then pooled over years to maximize sample sizes for comparing RS estimates among groups (i.e., estimation of relative reproductive success [RRS]).

Result
We observed a weak relationship between RS and origin (male p = 0.347; female p = 0.066), but a significant relationship between RS and return year (male p &lt; 0.001, η2 = 0.896; female p ⟨ 0.001, η2 = 0.867) (i.e., hatchery- and natural-origin fish did well or poorly together each year). Estimates of RRS for fish spawned in the hatchery ranged from 2.4 to 6.4, indicating that fish spawned in the hatchery produced more returning adult progeny than did fish allowed to spawn in the natural environment. Estimates of RRS were ⟨1.0 for hatchery-origin fish spawning in the natural environment, but the difference was nonsignificant for males and marginally significant for females. Hatchery-origin fish exhibited reduced genetic diversity as well as evidence of increased temporal population structure.

Conclusion
We conclude that the program was successful in achieving an increase in adult returns but not in avoiding negative genetic effects on the population and that any lasting impacts of supplementation remain to be determined.
Genome‐wide association study of soluble solids content, flesh color, and fruit shape in citron watermelon
Authors: Katuuramu Dennis N. , Levi Amnon , Wechter William P. 
Published: September 2023

AbstractFruit quality traits are crucial determinants of consumers’ willingness to purchase watermelon produce, making them major goals for breeding programs. There is limited information on the genetic underpinnings of fruit quality traits in watermelon. A total of 125 citron watermelon (Citrullus amarus) accessions were genotyped using single nucleotide polymorphisms (SNPs) molecular markers generated via whole‐genome resequencing. A total of 2,126,759 genome‐wide SNP markers were used to uncover marker‐trait associations using single and multi‐locus GWAS models. High broad‐sense heritability for fruit quality traits was detected. Correlation analysis among traits revealed positive relationships, with the exception of fruit diameter and fruit shape index (ratio of fruit length to fruit diameter), which was negative. A total of 37 significant SNP markers associated with soluble solids content, flesh color, fruit length, fruit diameter, and fruit shape index traits were uncovered. These peak SNPs accounted for 2.1%–23.4% of the phenotypic variation explained showing the quantitative inheritance nature of the evaluated traits. Candidate genes relevant to fruit quality traits were uncovered on chromosomes Ca01, Ca03, Ca06, and Ca07. These significant molecular markers and candidate genes will be useful in marker‐assisted breeding of fruit quality traits in watermelon.
Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance
Authors: Dutta Bamaprasad , Loo Shining , Kam Antony , Tam James P. 
Published: September 2023

AbstractInsulin-resistant diabetes is a common metabolic disease with serious complications. Treatments directly addressing the underlying molecular mechanisms involving insulin resistance would be desirable. Our laboratory recently identified a proteolytic-resistant cystine-dense microprotein from huáng qí (Astragalus membranaceus) called α-astratide aM1, which shares high sequence homology to leginsulins. Here we show that aM1 is a cell-penetrating insulin mimetic, enters cells by endocytosis, and activates the PI3K/Akt signaling pathway independent of the insulin receptor leading to translocation of glucose transporter GLUT4 to the cell surface to promote glucose uptake. We also showed that aM1 alters gene expression, suppresses lipid synthesis and uptake, and inhibits intracellular lipid accumulation in myotubes and adipocytes. By reducing intracellular lipid accumulation and preventing lipid-induced, PKCθ-mediated degradation of IRS1/2, aM1 restores glucose uptake to overcome insulin resistance. These findings highlight the potential of aM1 as a lead for developing orally bioavailable insulin mimetics to expand options for treating diabetes.
Synthetic coumarin derivatives with anticoagulation and antiplatelet aggregation inhibitory effects
Authors: Ramsis Triveena M. , Ebrahim Maha A. , Fayed Eman A. 
Published: September 2023

AbstractThrombosis is the leading cause of illness and mortality worldwide, posing a serious risk to human health and life. Because antithrombotic drugs can prevent the beginning and progression of thrombotic disorders, they are essential in the management of thrombotic diseases. The substantial side effects and unsatisfactory efficacy of present antithrombotic drugs stimulate the search for novel, effective, and safer antithrombotic therapies. Natural and synthetic coumarins have been shown to have antithrombotic action, specifically anticoagulation, and antiplatelet aggregation. In particular, coumarin-based medications like warfarin, phenprocoumon, and cloricromen have long been used to treat thrombosis in clinical settings. The favored structure for creating novel antithrombotic medications with diverse modes of action is coumarin, which has low toxicity. The goal of the current review is to consolidate recent findings on the development of coumarins as antithrombotic agents, with a focus on the connection between these compounds’ chemical compositions and therapeutic potency. It aims to offer promising suggestions for the identification of new coumarin compounds with potent antithrombotic properties.
Genus-specific response of kelp photosynthetic pigments to decomposition
Authors: Wright Luka Seamus , Kregting Louise 
Published: September 2023

AbstractDetritus is widely considered to be dead organic matter. However, recent studies have shown that kelp detritus can be functionally equivalent to the attached plant. This is significant, because detritus makes up ~ 42% of all plant biomass. In the Northeast Atlantic, studies on detrital photobiology have been restricted to the genus Laminaria. Here, we present data from a 46 d in situ experiment investigating the effect of decomposition on detrital photosynthetic pigment concentrations and stoichiometry in four Northeast Atlantic kelp species from three genera. We corroborate the lack of a decomposition effect on pigments of cold temperate Laminaria species as identified by previous studies but show that the photophysiology of other kelp genera responds differently. While Saccharina latissima displays an idiosyncratic parabolic response, the annual and thermally plastic kelp Saccorhiza polyschides seems to become less pigmented with increasing detrital age. If S. polyschides becomes increasingly dominant in future parts of a warmer Northeast Atlantic, this may translate to lower detrital photosynthetic potential at the forest scale. However, given our somewhat ambiguous data on this species, this conjecture requires further investigation into detrital photosynthesis.