bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetically Programmable Vesicles for Enhancing CAR‐T Therapy against Solid Tumors
Authors: Li Xianjun , Zhu Tianchuan , Wang Ronghao , Chen Jian , Tang Lantian , Huo Wenwen , Huang Xi , Cao Qingdong 
Published: February 2023

AbstractChimeric antigen receptor‐T (CAR‐T) cell therapy has shown remarkable success in eradicating hematologic malignancies; however, its efficacy in treating solid tumors has always been limited due to the presence of an immune‐suppressive tumor microenvironment (TME). Here, genetically programmable cellular vesicles expressing high‐affinity anti‐programmed death‐ligand 1 single chain variable fragment (anti‐PD‐L1 scFv) loaded with glutamine antagonist (D@aPD‐L1 NVs) are developed to metabolically dismantle the immunosuppressive TME and enhance the efficiency of anti‐mesothelin CAR‐T cells in orthotopic lung cancer. As anti‐PD‐L1 scFv can specifically bind to the programmed death‐ligand 1 (PD‐L1) on tumor cells, D@aPD‐L1 NVs enable the targeted delivery of glutamine antagonists to the tumor site and address the upregulation of PD‐L1 on tumor cells, which prevents the premature exhaustion of CAR‐T cells. More importantly, D@aPD‐L1 NVs effectively reduce the number of immunosuppressive cells and promote the recruitment of inflammatory cells and the secretion of inflammatory cytokines in tumor tissues. These unique features of D@aPD‐L1 NVs improve the infiltration and effector functions of CAR‐T cells, which ultimately enhance the anti‐tumor ability and long‐term memory immunity of CAR‐T cells. The findings support that D@aPD‐L1 NVs act as a promising drug to strengthen the effectiveness of CAR‐T cells against solid tumors.
Precuring Matrix Viscosity Controls Thermal Conductivity of Elastomeric Composites with Compression‐Activated Liquid and Solid Metallic Filler Networks
Authors: Uppal Aastha , Kong Wilson , Rana Ashish , Lee Jae Sang , Green Matthew D. , Rykaczewski Konrad , Wang Robert Y. 
Published: February 2023

AbstractPolymer matrix composites with liquid metal droplet and solid particle fillers are promising candidates for thermal interface materials (TIMs) used in electronics thermal management. To achieve good thermal transport, the particle and droplet fillers must be interconnected to form thermally conductive percolation pathways in the polymer matrix. This in turn requires displacement of the polymer between fillers as well as rupture of the oxide shell on the liquid metal droplets. This study demonstrates a multipronged strategy to achieve extensive filler bridging and a high thermal conductivity polymer TIM pad. The strategy synergistically employs reactive solid and liquid microscale fillers, a polymer matrix with tuned precure viscosity, and mechanical compression during thermal curing of the composite. The data demonstrate that the viscosity of the precursor polymer solution prior to curing plays a major role in the resulting thermal conductivity. More specifically, samples made with low viscosity ≈100 cSt solutions achieve a high thermal conductivity of ≈15 W m−1 K−1 at a curing pressure of 2 MPa. This thermal conductivity is double that achieved with high viscosity ≈2300 cSt solutions. Since many polymer systems employed in industry and research have a high precure viscosity, this insight has important implications for next‐generation TIMs.
Solar‐Triggered Engineered 2D‐Materials for Environmental Remediation: Status and Future Insights
Authors: Ikram Muhammad , Raza Ali , Ahmad Syed Ossama Ali , Ashfaq Atif , Akbar Muhammad Usama , Imran Muhammad , Dilpazir Sobia , Khan Maaz , Khan Qasim , Maqbool Muhammad 
Published: February 2023

AbstractModern‐day society requires advanced technologies based on renewable and sustainable energy resources to face the challenges regarding environmental remediation. Solar‐inspired photocatalytic applications for water purification, hydrogen and oxygen evolution, carbon dioxide reduction, nitrogen fixation, and removal of bacterial species seem to be unique solutions based on green and efficient technologies. Considering the unique electronic features and larger surface area, 2D photocatalysts have been broadly explored for the above‐mentioned applications in the past few years. However, their photocatalytic potential has not been optimized yet to the adequate level of practical and commercial applications. Among many strategies available, surface and interface engineering and the hybridization of different materials have revealed pronounced potential to boost the photocatalytic potential of 2D materials. This feature review recapitulates recent advancements in engineered materials that are 2D for various photocatalysis applications for environmental remediation. Various surface and interface engineering technologies are briefly discussed, like anion–cation vacancies, pits, distortions, associated vacancies, etc., along with rules and parameters. In addition, several hybridization approaches, like 0D/2D, 1D/2D, 2D/2D, and 3D/2D hybridization, etc., are also deeply investigated. Lastly, the application of these engineered 2D materials for various photocatalytic applications, challenges, and future perspectives is extensively explored.
Green Light Photoelectrocatalysis with Sulfur‐Doped Carbon Nitride: Using Triazole‐Purpald for Enhanced Benzylamine Oxidation and Oxygen Evolution Reactions
Authors: Jerigova Maria , Markushyna Yevheniia , Teixeira Ivo F. , Badamdorj Bolortuya , Isaacs Mark , Cruz Daniel , Lauermann Iver , Muñoz‐Márquez Miguel Ángel , Tarakina Nadezda V. , López‐Salas Nieves , Savateev Oleksandr , Jimenéz‐Calvo Pablo 
Published: February 2023

AbstractMaterials dictate carbon neutral industrial chemical processes. Visible‐light photoelectrocatalysts from abundant resources will play a key role in exploiting solar irradiation. Anionic doping via pre‐organization of precursors and further co‐polymerization creates tuneable semiconductors. Triazole derivative‐purpald, an unexplored precursor with sulfur (S) container, combined in different initial ratios with melamine during one solid‐state polycondensation with two thermal steps yields hybrid S‐doped carbon nitrides (C3N4). The series of S‐doped/C3N4‐based materials show enhanced optical, electronic, structural, textural, and morphological properties and exhibit higher performance in organic benzylamine photooxidation, oxygen evolution, and similar energy storage (capacitor brief investigation). 50M‐50P exhibits the highest photooxidation conversion (84 ± 3%) of benzylamine to imine at 535 nm – green light for 48 h, due to a discrete shoulder (≈700) nm, high sulfur content, preservation of crystal size, new intraband energy states, structural defects by layer distortion, and 10–16 nm pores with arbitrary depth. This work innovates by studying the concomitant relationships between: 1) the precursor decomposition while C3N4 is formed, 2) the insertion of S impurities, 3) the S‐doped C3N4 property‐activity relationships, and 4) combinatorial surface, bulk, structural, optical, and electronic characterization analysis. This work contributes to the development of disordered long‐visible‐light photocatalysts for solar energy conversion and storage.
Multiplex Identification of Post‐Translational Modifications at Point‐of‐Care by Deep Learning‐Assisted Hydrogel Sensors
Authors: Qin Junjie , Guo Jia , Tang Guanghui , Li Lin , Yao Shao Q. 
Published: February 2023

AbstractMultiplex detection of protein post‐translational modifications (PTMs), especially at point‐of‐care, is of great significance in cancer diagnosis. Herein, we report a machine learning‐assisted photonic crystal hydrogel (PCH) sensor for multiplex detection of PTMs. With closely‐related PCH sensors microfabricated on a single chip, our design achieved not only rapid screening of PTMs at specific protein sites by using only naked eyes/cellphone, but also the feasibility of real‐time monitoring of phosphorylation reactions. By taking advantage of multiplex sensor chips and a neural network algorithm, accurate prediction of PTMs by both their types and concentrations was enabled. This approach was ultimately used to detect and differentiate up/down regulation of different phosphorylation sites within the same protein in live mammalian cells. Our developed method thus holds potential for POC identification of various PTMs in early‐stage diagnosis of protein‐related diseases.
Sulfone‐Embedded Heterocyclic Narrowband Emitters with Strengthened Molecular Rigidity and Suppressed High‐Frequency Vibronic Coupling
Authors: Jiang Simin , Yu Yue , Li Deli , Chen Zijian , He Yanmei , Li Mengke , Yang Guo‐Xi , Qiu Weidong , Yang Zhihai , Gan Yiyang , Lin Jianying , Ma Yuguang , Su Shi‐Jian 
Published: February 2023

AbstractSulfone‐embedded heterocyclics are of great interest in organic light‐emitting diodes (OLEDs), however, exploring highly efficient narrowband emitters based on sulfone‐embedded heterocyclics remains challenging. Herein, five emitters with different sulfur valence state and molecular rigidity, namely tP, tCPD, 2tCPD, tPD and tPT, are thoroughly analysed. With restricted twisting of flexible peripheral phenyl by strengthening molecular rigidity, molecular emission spectra can be enormously narrowed. Further, introducing the sulfone group with bending vibration in low‐frequency region that suppresses high‐frequency vibration, sharp narrow full‐widths at half‐maximum of 28 and 25 nm are achieved for 2tCPD and tPD, respectively. Maximum external quantum efficiencies of 22.0 % and 27.1 % are successfully realized for 2tCPD‐ and tPD‐based OLED devices. These results offer a novel design strategy for constructing narrowband emitters by introducing sulfone group into a rigid molecular framework.
Design, Synthesis, and Application of a Water‐soluble Photocage for Aqueous Cyclopentadiene‐based Diels‐Alder Photoclick Chemistry in Hydrogels
Authors: Bailey Sophia J. , Hopkins Erik , Rael Kiara D. , Hashmi Arsalan , Urueña Juan Manuel , Wilson Maxwell Z. , Read de Alaniz Javier 
Published: February 2023

AbstractSpatiotemporally functionalized hydrogels have exciting applications in tissue engineering, but their preparation often relies on radical‐based strategies that can be deleterious in biological settings. Herein, the computationally guided design, synthesis, and application of a water‐soluble cyclopentadienone‐norbornadiene (CPD‐NBD) adduct is disclosed as a diene photocage for radical‐free Diels‐Alder photopatterning. We show that this scalable CPD‐NBD derivative is readily incorporated into hydrogel formulations, providing gels that can be patterned with dienophiles upon 365 nm uncaging of cyclopentadiene. Patterning is first visualized through conjugation of cyanine dyes, then biological utility is highlighted by patterning peptides to direct cellular adhesion. Finally, the ease of use and versatility of this CPD‐NBD derivative is demonstrated by direct incorporation into a commercial 3D printing resin to enable the photopatterning of structurally complex, printed hydrogels.
Molecularly Imprinted Nanobeacons Redirect Innate Immune Killing towards Triple Negative Breast Cancer
Authors: Guan Peixin , Guo Zhanchen , Xu Shuxin , Lu Haifeng , Wang Lisheng , Gu Zikuan , Liu Zhen 
Published: February 2023

AbstractHarnessing innate immunity is an appealing strategy for cancer treatment. Herein, we report a new strategy called molecularly imprinted nanobeacons (MINBs) for redirecting innate immune killing towards triple‐negative breast cancer (TNBC). The MINBs were molecularly imprinted nanoparticles with the N‐epitope of glycoprotein nonmetastatic B (GPNMB) as the template and grafted with plentiful fluorescein moieties as the hapten. The MINBs could tag the TNBC cells via binding with GPNMB and thereby provide navigation for recruiting hapten‐specific antibodies. The gathered antibodies could further trigger effective Fc‐domain‐mediated immune killing towards the tagged cancer cells. In vivo experiments showed that the TNBC growth was significantly inhibited after MINBs treatment by intravenous injection as compared with control groups. This study not only opens a new access for redirecting innate immunity towards TNBC but also paves the way for innate immunity‐based therapy of other diseases.
A Bifunctional Electrocatalyst for OER and ORR based on a Cobalt(II) Triazole Pyridine Bis‐[Cobalt(III) Corrole] Complex
Authors: Aljabour Abdalaziz , Awada Houssein , Song Luyang , Sun He , Offenthaler Simon , Yari Farzaneh , Bechmann Matthias , Scharber Markus Clark , Schöfberger Wolfgang 
Published: February 2023

AbstractAs alternative energy sources are essential to reach a climate‐neutral economy, hydrogen peroxide (H2O2) as futuristic energy carrier gains enormous awareness. However, seeking for stable and electrochemically selective H2O2 ORR electrocatalyst is yet a challenge, making the design of—ideally—bifunctional catalysts extremely important and outmost of interest. In this study, we explore the application of a trimetallic cobalt(II) triazole pyridine bis‐[cobalt(III) corrole] complex CoIITP[CoIIIC]2 3 in OER and ORR catalysis due to its remarkable physicochemical properties, fast charge transfer kinetics, electrochemical reversibility, and durability. With nearly 100 % selective catalytic activity towards the two‐electron transfer generated H2O2, an ORR onset potential of 0.8 V vs RHE and a cycling stability of 50 000 cycles are detected. Similarly, promising results are obtained when applied in OER catalysis. A relatively low overpotential at 10 mA cm−2 of 412 mV, Faraday efficiency 98 % for oxygen, an outstanding Tafel slope of 64 mV dec−1 combined with superior stability.
High fire stability cement composite cementitious material based on semi‐dry gas desulfurized ash/blast furnace slag system: The synergistic effect of nano‐TiO2 and nano‐SiO2
Authors: Yu Xian‐kun , Xu Xiu‐ping , Yang Xiao‐jun , Zhang Hao , Gao Tian‐ci 
Published: February 2023

AbstractCement is an important way to digest industrial waste. Semi‐dry gas desulfurized ash (SGDA) and granulated blast furnace slag (GBFS) as solid waste both have pozzolanic activity as well as small particle size and continuous particle size distribution, which allow their use as cement mixtures. In the present work, a cement matrix with 60% Portland cement, 20% SGDA, and 20% GBFS, including 3% nano‐TiO2 and 2% nano‐SiO2 as dopants, was produced via cement slurry mixing process. The obtained matrix was found to have the better 3‐ and 28‐day age compressive strength (by 104% and 116%, respectively) as compared with the pure Portland cement; the mortar compressive strength is also improved. The imaging and mineralogical analysis revealed that the nanomodified cement matrix had a more compact structure along with a well‐developed crystal form and the uniform micropore distribution. Furthermore, the doped cement mixture exhibited good fire resistance: Even after exposure to simulated fire conditions for 2.5 h at 450°C, the compressive strength of the composite was 98.27% of its initial value (57 MPa) and the microstructure remained undestroyed. The findings of this study open up new prospects for collaborative use of SGDA and GBFS as solid waste along with nano‐TiO2 and nano‐SiO2 as dopants, therefore providing outstanding fire stability of related composites.
Theoretical design and discovery of two‐dimensional materials for next‐generation flexible piezotronics and energy conversion
Authors: Sachdeva Parrydeep Kaur , Bera Chandan 
Published: February 2023

AbstractTwo‐dimensional (2D) materials are at the epicenter of the current nanotechnology research for its intriguing properties. It has the advantage of high flexibility, high surface to volume ratio, robust mechanical strength and are stackable in contrary to bulk materials. Piezoelectric effect is exploited in 2D layered nanomaterials with broken inversion symmetry and non‐zero band gap for applications in energy harvesting and energy conversion. Density functional theory (DFT) is a powerful tool to predict the piezoelectric properties of 2D materials. This mini review emphasizes the importance and discusses the challenges of different methods within DFT‐based framework to compute piezoelectric properties. Recent simulation works of piezoelectric engineering in novel 2D semiconductors for in‐plane and out‐of‐plane piezoelectricity are reviewed. Various controlling parameters and techniques for piezoelectric effect are also discussed. Theoretical predictions pave the path for experimental exploration of 2D materials exhibiting strong piezoelectric properties and to replace the commercially used lead‐based toxic materials in future devices.
Digitales Bauen auf der Baustelle – Einsatzszenarien und Optimierungspotenzial
Authors: Farhat Rokhshid 
Published: February 2023

AbstractDas Thema digitales Bauen bzw. Building Information Modeling (BIM) bietet enormes Potenzial, Prozesse rund um das Planen, Bauen und Betreiben zu optimieren und somit effizienter bzw. wirtschaftlicher zu arbeiten. Während der Fokus häufig auf der Beschleunigung und Verbesserung von Planungs‐ und Genehmigungsprozessen liegt, können auch die Abläufe auf der Baustelle während der Bauausführungsphase verbessert werden. Bei STRABAG wird bereits heute eine Vielzahl von Arbeiten auf der Baustelle durch digitale Methoden und Werkzeuge unterstützt und somit der Bauablauf und die Qualität der Bauwerke verbessert. Im Rahmen dieses Beitrags werden Praxisbeispiele für den Einsatz digitaler Methoden im Verkehrswegebau aufgezeigt, ihr Einfluss auf den Bauablauf erörtert und notwendige Voraussetzungen für einen effizienten Einsatz digitaler Methoden erläutert. Im Speziellen soll das Thema Bauteiltracking im Kanalbau fokussiert werden. Im Kanalbau müssen Rohre und Schächte bestellt, produziert, geliefert und montiert werden. Dabei sind v. a. Schachtunterteile Individualbauteile, die auf Grundlage der vorliegenden Planung gefertigt werden müssen. Der Bestell‐, Liefer‐ und Montageprozess dieser Bauteile ist nicht nur zeitaufwendig, sondern erfordert ein hohes Maß an logistischer Vorplanung. Um diese Schritte zu vereinfachen, wurde das digitale Bauteiltracking entwickelt, wodurch es gelungen ist, den Kanalbau effizienter und wirtschaftlicher zu gestalten.
Multiple‐length scale investigation of Pt/C degradation by identical‐location transmission electron microscopy
Authors: Kwag Jimin , Kim Sungin , Kang Sungsu , Park Jungwon 
Published: February 2023

AbstractPt‐based electrocatalysts on the cathode side of proton exchange membrane fuel cells (PEMFCs) generally undergo severe degradation, which contributes to the short life span of PEMFCs. Thus, it is crucial to understand the structural degradation of Pt‐based electrocatalysts. Here, various degradation mechanisms of individual Pt nanoparticles supported on Vulcan carbon during load‐cycle accelerated stress tests were investigated and quantified by identical‐location transmission electron microscopy (IL‐TEM). The atomic‐scale IL‐STEM imaging revealed the formation of Pt single atoms on the carbon support, which resulted from the dissolution of nanoparticles, and the following pathway change in the oxygen reduction reaction (ORR) was analyzed by rotating ring‐disk electrode tests. Our study provides new insight for understanding the relationship between the decline in the ORR activity and the formation of Pt atomic species resulting from the electrochemical degradation of Pt/C.
HaloTag‐Based Reporters for Fluorescence Imaging and Biosensing
Authors: Cook Alexander , Walterspiel Franziska , Deo Claire 
Published: February 2023

AbstractVisualizing the structure and dynamics of biomolecules is critical to understand biological function, and requires methods to fluorescently label targets of interest in their cellular context. Self‐labelling proteins, which combine a genetically encoded tag with a small‐molecule fluorophore, have attracted considerable attention for this purpose, as they can overcome limitations of fluorescent proteins. Among them, the HaloTag protein is the most broadly used, showing fast specific labelling with a small, easy to functionalize and cell‐permeant ligand. Synthetic chemistry and protein engineering have provided a portfolio of powerful imaging tools exploiting HaloTag, along with general methods to optimize and adapt them to specific applications. Here, we provide an overview of fluorescent reporters based on the HaloTag protein for imaging and biosensing, highlighting engineering strategies and general applications.
Challenging case of severe acute asthma in a mechanically ventilated patient managed with sevoflurane
Authors: Munusamy Satheesh , Monfared Seyedeh Saba Nabavi , Iqbal Phool , Abdussalam Ahmed Lutfe Mohamad 
Published: February 2023

AbstractAcute severe bronchial asthma is a chronic inflammatory disease characterized by hyperresponsiveness of the airways leading to bronchoconstriction. We present a case of refractory life‐threatening bronchial asthma that was managed with sevoflurane gas along with the standard treatment and achieved stability and clinical improvement through its bronchodilator and anesthetic effect.
Control of Selectivity in Homogeneous Catalysis through Noncovalent Interactions
Authors: Mahmudov Kamran T. , Pombeiro Armando J. L. 
Published: February 2023

AbstractThe regio‐, site‐, stereo‐ or chemoselective homogeneous catalytic transformations are extremely important for the growth/success of the current chemical industry. Based on empirical, theoretical or intuitive knowledge, several synthetic strategies, such as ligand design, transient directing group, metal node alternation, metal‐ligand cooperation, pore decoration, biomimetic, have already been developed for the selective functionalization of organic substrates. In comparison to the other tactics, the use of noncovalent interactions for the control of selectivity in catalytic transformations of organic compounds may avoid multi‐steps, reduce time of synthetic procedure, decrease cost of operation, and increase reactivity of catalyst. In fact, enzymes achieve a high selectivity through noncovalent interactions in biochemical processes in Nature. Guided by the impressive performance of enzymes in biosynthesis and biodegradation reactions, various types of synthetic metal complex or organocatalysts have already been developed, in which the catalyst‐substrate noncovalent interactions have a pivotal impact on the distinctive stabilization of the transition states or intermediates, directing selectivity and improving efficiency of homogeneous catalytic reactions. Herein, we highlight several recent and relevant examples of selectivity directing/driving function of noncovalent interactions in the transformation of organic substrate(s) catalyzed by both organocatalysts and metal complex catalysts.
Combinatorial Coordination Self‐Assembly for Organopalladium Cages with Fine‐Tuned Structure and Function
Authors: Tian Chong‐Bin , Sun Qing‐Fu 
Published: February 2023

AbstractDiscrete organopalladium coordination cages have shown great potential in applications ranging from molecular recognition and sensing, drug delivery to enzymatic catalysis. While many of the known organopalladium cages are homoleptic structures with regular polyhedral shapes and symmetric inner cavities, heteroleptic cages with complex architectures and new functions coming from their anisotropic cavities have received an increasing attention recently. In this concept article, we discuss a powerful combinatorial coordination self‐assembly strategy toward the construction of a family of organopalladium cages, including both homoleptic and heteroleptic ones, from a given library of ligands. Within such a cage family, the heteroleptic cages often feature systematically fine‐tuned structures and emergent properties, distinct from their parent homoleptic counterparts. We hope the concepts and examples provided in this article can offer some rational guidance for the design of new coordination cages toward advanced functions.