bluuebunny/crossref_metadata_2025_split huggingface dataset:
A probabilistic knowledge graph for target identification
Authors: Zeng Jianyang , Liu Chang , Xiao Kaimin , Yu Cuinan , Lei Yipin , Lyu Kangbo , Tian Tingzhong , Zhao Dan , Zhou Fengfeng , Tang Haidong 
Published: January 2023

Abstract
Early identification of safe and efficacious targets is crucial to alleviating the tremendous cost of drug discovery projects. However, existing experimental methods for identifying new targets are generally labor-intensive and failure-prone. On the other hand, computational approaches, especially the machine learning-based frameworks, have shown remarkable application potential in drug discovery. In this work, we propose Progeni, a novel machine learning-based framework for target identification. In addition to fully exploiting the known heterogeneous biological networks from various sources, Progeni integrates literature evidence about the relations between biological entities to construct a probabilistic knowledge graph. Graph neural networks are then employed in Progeni to learn the feature embeddings of biological entities to facilitate the identification of biologically relevant target candidates. A comprehensive evaluation of Progeni demonstrated its superior predictive power over the baseline methods on the target identification task. In addition, our extensive tests showed that Progeni exhibited high robustness to the negative effect of exposure bias, a common phenomenon in recommendation systems, and effectively identified new targets that can be strongly supported by the literature. Moreover, our wet-lab experiments successfully validated the biological significance of the top target candidates predicted by Progeni for melanoma and colorectal cancer. All these results suggested that Progeni can identify biologically effective targets and thus provide a powerful and useful tool for advancing the drug discovery process.
Magnetic Memory Signal Analysis Method Based on Information Fusion
Authors: Wang YiBo , Ma ShiBo , Zhen-Kai Mu , Wei Wang , Yan HuaJun , Zhang ShuangJie 
Published: January 2023

Abstract
In order to analyze the tensile stage of the sample by magnetic memory detection technology, a variety of information entropy is introduced to process and analyze the magnetic memory signal. The information entropy of the magnetic signal under different tensile loads was calculated, and used as a criterion to judge the state of the tensile sample. An information fusion strategy coupled with Dempster synthesis rule was proposed to improve the accuracy and reliability of the state recognition. Based on the Dempster synthesis rule and D-S evidence theory, a state identification algorithm was developed by using Matlab software, which can easily obtain the deformation state of different regions on the sample surface. The experimental results show that the data analysis method can quickly and accurately judge the tensile stage of the sample.
In vitro model of brain endothelial cell barrier reveals alterations induced by Plasmodium blood stage factors
Authors: Pais Teresa F. , Penha-Gonçalves Carlos 
Published: January 2023

Abstract
Cerebral malaria (CM) is a severe neurological condition caused by Plasmodium falciparum. Disruption of the brain-blood barrier (BBB) is a key pathological event leading to brain edema and vascular leakage in both humans and in the mouse model of CM. Interactions of brain endothelial cells with infected red blood cells (iRBCs), and with circulating inflammatory mediators and immune cells contribute to BBB dysfunction in CM. Adjunctive therapies for CM aim at preserving the BBB to prevent neurologic deficits. Experimental animal and cellular models are essential to develop new therapeutic strategies. However, in mice, the disease develops rapidly, which offers a very narrow time window for testing the therapeutic potential of drugs acting in the BBB. Here, we establish a brain endothelial cell barrier whose disturbance can be monitored by several parameters. Using this system, we found that incubation with iRBCs and with extracellular particles (EPs) released by iRBCs changes endothelial cell morphology, decreases the tight junction protein zonula occludens-1 (ZO-1), increases the gene expression of the intercellular adhesion molecule 1 (ICAM-1) and induces a significant reduction in transendothelial electrical resistance (TEER) with increased permeability. We propose this in vitro experimental setup as a straightforward tool to investigate molecular interactions and pathways causing endothelial barrier dysfunction and to test compounds that may target BBB and be effective against CM. A pre-selection of the effective compounds that strengthen the resistance of the brain endothelial cell barrier to Plasmodium-induced blood factors in vitro may increase the likelihood of their efficacy in preclinical disease mouse models of CM and in subsequent clinical trials with patients.
Analytical Interference with Contrast Agents in Genetic Test Result for Thrombophilia
Authors: Oz Ozlem , Gonel Ataman 
Published: January 2023

Background:
Diagnostic and therapeutic drugs can change the laboratory results of patients by
interfering with the measurement method and may compromise diagnostic efficiency. Incorrect results in
biochemical tests used in the clinical follow-up of a patient during treatment may lead to improper applications.
Unfortunately, this situation leads the clinician to misdiagnosis.

Objective:
The focus of this cross-sectional study is to investigate the effects of three different radiopaque
substances commonly used in the clinic on thrombophilia molecular genetic results.

Methods:
Peripheric blood samples from three patients whose thrombophilia panel was planned to be
studied were included. Blood samples that did not contain any radiopaque material or distilled water were
studied as a control group. Except for the control group four different study groups were formed by adding
distilled water, Ioversol, Fluorescein Na, and Gadobutrol. This radiopaque substances were added at a
ratio of 1/10 to each patient's blood sample before DNA isolation. Prothrombin G20210A, MTHFR
C677T, MTHFR A1298C, Factor V Leiden G169A and PAI-1 4G/5G mutations were studied by Real
Time-PCR method.

Results:
There was no change at the thrombophilia panel results in the study groups compared with the
control groups in patients 1 and 3. In patient 2, there was no change when the result of MTHFR C677T
was compared to the results of blood+DW and blood+Gadobutrol. But there were alterations in
blood+Ioversol and blood+Fluorescein Na samples; the result of heterozygous MTHFR C677T was observed
to change to homozygous MTHFR C677T.

Conclusion:
This study showed that Ioversol and Fluorescein Na could change the results of the thrombophilia
genetic analysis for MTHFR C677T mutation. It should be kept in mind that the results of the
thrombophilia panel analysis may change after the injection of radiopaque substances.
Evaluation of Microbiological Culture and Antibiogram of the Patient
with Corneal Ulcer due to Exposure Keratitis in the Intensive Care Unit
in Sina Farshchian Hospital (2019-2020)
Authors: Eslami-Ghayour Anahita , Taher Abbas , Eslami Fatemeh , Ghasemibasir Hamidreza , Irani Amin Dosti , Eslami-Ghayour Arash 
Published: January 2023

Background:
Since patients admitted to the intensive care unit have a compromised immune
system and are more prone to infection than other patients, timely diagnosis and treatment of
corneal ulcers among this group of patients can prevent vision loss. Therefore, it is necessary to treat
eye infections and corneal ulcers promptly and economize prohibitive costs.

Objective:
Appropriate treatment with the most effective antibiotic before the answer is available to
prevent corneal ulcer complications and blindness.

Methods:
This study was conducted from November 2019 to November 2020 and after approval by
the ethics committee of Hamedan University of Medical Sciences with the code of ethics:
IR.UMSHA.REC.1398.716. First, the corneal secretions of 121 patients admitted to the intensive care
unit of Sina Hospital are prepared by an ophthalmologist (after anesthetizing the cornea with tetracaine
drops and sterile swabs) and culture in four growth mediums (blood agar, chocolate agar, thioglycolate,
and EMB). Microbial cultures are examined after 48 hours and a fungal culture is examined
one week later. Disc diffusions are placed in positive microbial cultures. Antibiotic susceptibility or
resistance of the antibiogram was recorded. Other demographic data, including patients' age and sex,
are extracted from ICU files. Also, test results and patient identifications are recorded in a checklist
designed for this purpose.

Results:
Of all the antibiotics used against common bacteria, vancomycin (84%), colistin (80.43%),
cefazolin (80%), and levofloxacin (60%) had the highest sensitivity and gentamicin (93.75%),
ceftazidime (86.42%) Erythromycin (85%) had the highest resistance against isolated bacteria.

Conclusion:
The data obtained from this study showed that the most common microorganisms in the
age group under the age of 30 years were Acinetobacter Baumannii, in the group of 30-60 years old
was Klebsiella pneumonia, and age group over 61 years old was Staphylococcus aureus, and the most
sensitive antibiotics in the age group under 30 years were vancomycin and levofloxacin and the age
group30-60 were colistin and vancomycin and in the age group over 61 years were vancomycin and
cefazolin.
Traditional Drugs Originating from Selected Medicinal Plants: An Intervention
for Anaemia
Authors: Chalotra Rishabh , Dhanawat Meenakshi , Maivagna Chamasse Homary , Gupta Sumeet 
Published: January 2023

Background:
Anaemia is the most common disease that affects mostly females and children
and is most prevalent in developing countries. Among various causes sickle cell anaemia is
one of them, which is a cause of concern. Sickle Cell Disease (SCD) causes problems like blockage
of blood flow, causing pain, and fatigue and also leads to death.

Objective:
With the advancement in science, diseases that were once considered unable to cure can be
stopped or prevented and, in some cases, also be cured. As current therapies for the treatment of sickle
cell anaemia are limited, like blood transfusions, bone marrow transfusions, etc., a non-surgical method
where plant extracts or compounds were found effective in stopping, preventing, and in some cases reversal
of SCD. In this review, we tried to gather information about those plants and compounds.

Method:
Numerous surveys in the literature were performed to determine the plants which have
shown their potential against SCD. Relevant peer-reviewed publications were searched through various
databases such as ScienceDirect, PubMed, Google Scholar, Research Gate, etc.

Results:
A total of more than 50 medicinal plants such as Acacia catechu, Alchornea cordifolia,
Anchomanes difformis, Khayase negalensis, Terminalia catappa, etc., have been identified based on
their potential against SCD, and 15 compounds such as Butylurea, Glyceraldehyde, Potassium cyanate,
urea, etc., have also been identified which could work against SCD. These plants acting on
sickle cell anemia on various pathways are also discussed.

Conclusion:
In this review, an approach was made to study those plants which have an effect
against SCD, with proper mechanisms and compounds that show potency against this disease. So
that better treatment options could be available for future generations.
recuperación internacional de niños, niñas y adolescentes en Ecuador y la carencia de un procedimiento judicial para sustanciarlas
Authors: Dávila Álvarez Julia , Zuleta Sánchez Andrea 
Published: January 2023

El presente artículo busca determinar la falta de un procedimiento expedito para atender los procesos judiciales cuyo objeto de la controversia sea la recuperación internacional de niños, niñas y adolescentes, en los dos escenarios posibles, esto es, el Ecuador como estado requerido; o, como estado requirente. En primera instancia se analizó la normativa legal vigente que contempla la recuperación internacional de niños, niñas y adolescentes, así como, la necesidad de que previamente se haya establecido la tenencia a favor de uno de los progenitores. A continuación, se revisaron si los procedimientos contemplados en el Código Orgánico General de Procesos COGEP, podrían ser considerados idóneos para atender esta clase de procedimientos judiciales, tomándose en consideración la urgencia y emergencia que se les debe dar, así como la posible situación de riesgo en la que pudiesen estar los niños, niñas y adolescentes que son separados de uno de sus padres, sin autorización del otro. Finalmente, se cotejará si la normativa actual guarda armonía con la convención sobre los aspectos civiles de la sustracción internacional de menores, instrumento internacional aprobado por el Ecuador; para de esta forma determinar que la carencia de un procedimiento expedido contraviene a lo determinado en dicha convención, a efectos de cumplir con todos los parámetros determinados en líneas anteriores, los métodos a emplearse son: el teórico – jurídico, exegético – jurídico y método jurídico comparado, así como, métodos empíricos: encuestas y entrevistas.
Estrategias agroecológicas para una agricultura sostenible
Authors: Aguilera Peña Roberto 
Published: January 2023

El presente artículo tiene como objetivo analizar las estrategias agroecológicas como una alternativa para la sostenibilidad de la agricultura campesina afectada en la rentabilidad ambiental, social y económica por las prácticas agrícolas impuestas por la revolución verde desde las primeras décadas del siglo XX. La agroecología como disciplina científica nace como un instrumento que a través de sus principios pretende transformar los sistemas agrícolas actuales y al mismo tiempo fortalecer los sistemas agroalimentarios para hacerlos sostenibles combinando la producción agrícola, la preservación y regeneración de los recursos naturales con una dimensión global. Para alcanzar estos objetivos la agroecología se fundamenta en varios principios entre ellos mejorar la fertilidad de los suelos, preservar la biodiversidad y los paisajes, aumentando la productividad de las fincas, mejorando las condiciones de vida de la familia campesina, proporcionando alimentos de calidad nutricional y analizar de manera simple los impactos de la agricultura convencional proponiendo que la academia reoriente las investigaciones y los proyectos de desarrollo agrícola a la resolución de los problemas de las comunidades campesinas.
Factores que contribuyen al aumento de la delincuencia en la ciudad de Guayaquil
Authors: Orellana Batallas Fabián , Alfonso Caveda Duniesky 
Published: January 2023

El presente trabajo de investigación tiene como finalidad detallar las posibles soluciones a la problemática planteada. En este caso, es el aumento en los índices delincuenciales en la ciudad de Guayaquil. Para el efecto, se toma en consideración bases teóricas con relación a los temas que serán introducidos dentro de la misma, para facilitar la comprensión del lector. El objetivo es establecer los principales factores que son considerados como un detonante para el aumento de hechos delictivos. La sociedad debe concientizar acerca de la importancia del cumplimiento de las leyes, fortaleciendo la teoría preventiva y represiva. La sustentación del análisis será en base a la información recolectada a través de la ardua investigación, junto con la implementación de un método cuantitativo y cualitativo. La aplicación del enfoque mixto logrará determinar los motivos por los cuales se produce una gran incidencia de delitos dentro de la ciudad de Guayaquil. La postura del grupo se inclina hacia la probabilidad de que el aumento de hechos delictivos tiene relación con las oleadas inmigratorias que han surgido en los últimos años dentro de la ciudad materia de estudio.
Lung Cancer Risk Prediction Nomogram in Nonsmoking Chinese Women: Retrospective Cross-sectional Cohort Study
Authors: Guo Lanwei , Meng Qingcheng , Zheng Liyang , Chen Qiong , Liu Yin , Xu Huifang , Kang Ruihua , Zhang Luyao , Liu Shuzheng , Sun Xibin , Zhang Shaokai 
Published: January 2023

Background
It is believed that smoking is not the cause of approximately 53% of lung cancers diagnosed in women globally.

Objective
The study aimed to develop and validate a simple and noninvasive model that could assess and stratify lung cancer risk in nonsmoking Chinese women.

Methods
Based on the population-based Cancer Screening Program in Urban China, this retrospective, cross-sectional cohort study was carried out with a vast population base and an immense number of participants. The training set and the validation set were both constructed using a random distribution of the data. Following the identification of associated risk factors by multivariable Cox regression analysis, a predictive nomogram was developed. Discrimination (area under the curve) and calibration were further performed to assess the validation of risk prediction nomogram in the training set, which was then validated in the validation set.

Results
In sum, 151,834 individuals signed up to take part in the survey. Both the training set (n=75,917) and the validation set (n=75,917) were comprised of randomly selected participants. Potential predictors for lung cancer included age, history of chronic respiratory disease, first-degree family history of lung cancer, menopause, and history of benign breast disease. We displayed 1-year, 3-year, and 5-year lung cancer risk–predicting nomograms using these 5 factors. In the training set, the 1-year, 3-year, and 5-year lung cancer risk areas under the curve were 0.762, 0.718, and 0.703, respectively. In the validation set, the model showed a moderate predictive discrimination.

Conclusions
We designed and validated a simple and noninvasive lung cancer risk model for nonsmoking women. This model can be applied to identify and triage people at high risk for developing lung cancers among nonsmoking women.
Learning Obstetrical Cervical Exam Skills : Development of a Novel Model to Demystify Blind Procedures
Authors: Little Sahoko H. , Heinrich Laura E. A. , Sen Ananda , Gold Katherine J. 
Published: January 2023

Background and Objectives: Obstetric care is a core element in family medicine education. New interns typically learn the sterile cervical exam on the job by examining women in labor. This can be uncomfortable for patients and may increase the risk of infection. Simulated training could minimize these challenges, but manufactured models are expensive and not widely available in residency programs. We sought to evaluate a simple, homemade sewn model using stretchy fabric and pipe cleaners that could improve teaching and acquisition of cervical examination skills and common obstetrical procedures.
Methods: We used the model to teach cervical examination skills to students and new interns and assessed participant satisfaction. We evaluated examination accuracy by grading practice exams on the model before and after a workshop teaching obstetrical procedures including the sterile vaginal exam. We calculated satisfaction using summary statistics. We evaluated pre- and postscores for exam accuracy using paired t tests.
Results: Interns demonstrated a significant improvement in cervical exam skills using the model, and participants reported very high satisfaction with the workshop utilizing the model.
Conclusions: We developed a simple, low-cost cervical exam model that was shown to be well-regarded by trainees and could be duplicated by other residency programs. This approach provides a unique and accessible way to offer hands-on simulation during obstetrical training. The model may improve trainees’ understanding of the procedures which would lead to better experiences for obstetrical patients.
PENGARUH KECAKAPAN LITERASI DIGITAL TERHADAP KINERJA GURU SEKOLAH MENENGAH KEJURUAN DI KABUPATEN GOWA
Authors: Dharma Surya 
Published: January 2023

This research was conducted with the aim of knowing the effect of digital literacy skills on the performance of Vocational High School teachers. The population in this study were all teachers who were civil servants at the State Vocational High School in Gowa Regency, totaling 238 teachers. The proportional random sampling technique was carried out in obtaining a research sample of 70 teachers who had previously used the slovin formula in determining the minimum number of research samples. questionnaire is an instrument in this research which in its development process is tested for content validity using the Gregory formula, construct validity using a confirmatory factor analysis (CFA) technique with a maximum likelihood approach, as well as testing the reliability of the instrument using the Cronbach alpha formula which produces a reliability coefficient value of 0.98 for the teacher's digital literacy skill instrument and a reliability coefficient value of 0.95 for the teacher's performance instrument. Simple linear regression technique was used to analyze the data obtained. The results of the study reveal that there is a positive and significant effect of digital literacy skills on the performance of Vocational High School teachers, and the contribution or influence of digital literacy skills on teacher performance is 39%.
A Comparative Study of the Early and Short-Term Outcomes of Aortic Replacement in Patients with Stanford type A Aortic Dissection and Ascending Aortic Aneurysm.
Authors: Anwar Erfan Omer , Haji Saeed Shkar Raouf , . Aram Baram 
Published: January 2023

Ascending aortic replacement is a challenging and complex surgery. The mortality, morbidity, and outcomes depend on the causes of the ascending aortic pathology and the type of operation. The research was conducted in a single-center, prospective, observational cohort study of patients undergoing ascending aortic replacement due to dissection or aneurysm. In the hospital, mortality, morbidity, and short-term outcomes were measured. A total of 85 patients were included in this study. Of them, 65.9% were male, and 34.1% were female. Thirty-three patients had Stanford type A aortic dissection (STAAD), whereas 52 had ascending aortic aneurysm (ASAA). Early mortality was (21.21% and 1.9%) for STAAD and ASAA, respectively, while the survival rate after one year was (75.8% and 96.15 %) for ascending dissection and aneurysm, respectively. The results of our study show higher early surgical mortality and morbidity and a lower short-term survival rate for STAAD surgery compared with ASAA surgery.
A Study of the Ministry of the Royal Priesthood in Exodus 19:6 and Its Theological Expansion 1 Peter 2:5, 9–10
Authors: Udoekpo Michael Ufok 
Published: January 2023

Ministry (sharāth/šrt) in the ot is grounded in the nature of God himself. It is grounded in the nature of God’s relationship with Israel, his people. Although the Israelites had many failures, God, with love, elected and called the Israelites—both as individuals and groups—his servants, calling them to serve and to minister to the people, who were themselves ministering, as well as to be servants to the servant people of the Lord. On this basis, this essay exegetically and theologically examines the priestly vocation of the ministering people, or the royal priesthood (mamleket kohănȋm [mt]; hierateuma (lxx]) in Exodus 19:6 and its related texts (Isa 61:6). It demonstrates its theological extension to the nt priestly people basileion hierateuma (1 Pet 2:5, 9–10; cf. Rev 1:6) in order to underline its theological implication for the vocation of the church, the body of Christ, in Africa and beyond.