bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Placental LRP5 and Sclerostin are Increased in Gestational Diabetes Mellitus Pregnancies
Authors: Papadopoulou Anna , Thymara Eirini , Maratou Eirini , Kanellopoulos George , Papaevangelou Vasiliki , Kalantaridou Sophia , Kanellakis Spyridon , Triantafyllidou Pinelopi , Valsamakis George , Mastorakos George 
Published: March 2023

Abstract

Introduction
The low-density lipoprotein receptor-related protein 5 (LRP5) and its inhibitor sclerostin, are key components of bone metabolism and potential contributors to type 2 diabetes mellitus susceptibility. This study aims at evaluating the expression of placental LRP5 and sclerostin in pregnancies with gestational diabetes mellitus (GDM) and investigate possible associations with umbilical sclerostin concentrations and clinical outcomes in mothers and their neonates.

Methods
Twenty-six GDM-mothers and 34 non-GDM mothers of Caucasian origin and their neonates admitted in a gynecology and obstetrics department of a university hospital were included in this study. Demographic data and maternal fasting glucose concentrations (24-28 weeks of gestation) were retrieved from the patients’ medical records. Placental LRP5 was determined by immunohistochemistry (IHC) and Western blotting analysis; placental sclerostin was determined by IHC. Umbilical serum sclerostin concentrations were measured by ELISA.

Results
Placental sclerostin IHC intensity values were positively correlated with LRP5 values as detected either by IHC (r = 0.529; P &lt; .001) or Western blotting (r = 0.398; P = .008), with pregestational maternal body mass index values (r = 0.299; P = .043) and with maternal fasting glucose concentrations (r = 0.475; P = .009). Placental sclerostin and LRP5 were significantly greater in GDM compared with non-GDM placentas (histo-score: 65.08 ± 17.09 vs 11.45 ± 2.33, P &lt; .001; 145.53 ± 43.74 vs 202.88 ± 58.65, P &lt; .001; respectively).

Discussion
Sclerostin and LRP5 were detected in human placentas. The overexpression of placental sclerostin and LRP5 values in GDM compared with non-GDM pregnancies, as well as the positive association of placental sclerostin values with pregestational maternal body mass index and maternal fasting glucose concentrations may indicate the development of an adaptive mechanism in face of maternal hyperglycemia.
Short Efficacy Evaluation of External Ventricular Drains Versus Ventriculosubgaleal Shunt in the Management of Neonatal Posthemorrhagic Hydrocephalus: A Retrospective Single-Center Cohort Study
Authors: Falsaperla Raffaele , Lo Bianco Manuela , Palmeri Antonio , Betta Pasqua , Altieri Roberto , Barbagallo Giuseppe Maria , Ruggieri Martino 
Published: March 2023

BACKGROUND:
Different temporizing neurosurgical procedures are available for the management of posthemorrhagic hydrocephalus in preterm newborns.

OBJECTIVE:
To evaluate the short efficacy of the external ventricular drains (EVDs) and the ventriculosubgaleal (VSG) shunt.

METHODS:
This is a Strengthening the Reporting of Observational Studies in Epidemiology–conformed retrospective cohort study. The inclusion criteria were (1) gestational age <37 weeks, (2) birth weight <1500 g, (3) posthemorrhagic hydrocephalus because of intraventricular hemorrhage grade II/III, and (4) EVD or VSG shunt procedure before ventriculoperitoneal (VP)-definite shunt. Twenty-four newborns were collected from 2006 to 2022. The end points considered were infectious events, proteinorrachia, reintervention rate, and time to conversion to definite VP shunt.

RESULTS:
Overall, 12/24 newborns underwent EVD, and the remnant had a VSG shunt. The results showed a statistically significant difference (P = .02) concerning cerebrospinal fluid infections between the EVD group (50%) and VSG shunt 1 (8.33%). The reintervention rate of EVD was significantly higher (66.67%) compared with that of the VSG shunt group (8.33%). A statistically significant difference was stated between the 2 groups (t[13] = −8.250; P < .001) (mean difference ± standard error; 10.5 ± 1.273) in the mean number of days elapsed from the achievement of the ideal weight (2000 g) to the definitive VP drainage.

CONCLUSION:
The increased infectious risk and the higher reintervention rate in EVD were confirmed in this study. In addition, a significant delay in the time to -conversion from EVD to VP shunt was demonstrated. Despite these optimal results, the VSG shunt remains a low practiced intervention, probably because of the limited operator experience.
Vegetables as a vehicle for antimicrobial resistance (vAMR): An agroecosystem exploration from the One Health perspective in India
Authors: Kalpana Pachillu , Falkenberg Timo , Yasobant Sandul , Saxena Deepak , Schreiber Christiane 
Published: March 2023

Introduction: Antimicrobial resistance (AMR) has emerged as one of the leading threats to public health. AMR possesses a multidimensional challenge that has social, economic, and environmental dimensions that encompass the food production system, influencing human and animal health. The One Health approach highlights the inextricable linkage and interdependence between the health of people, animals, agriculture, and the environment. Antibiotic use in any of these One Health areas can potentially impact the health of other areas. There is a dearth of evidence on AMR from the natural environment, such as the plant-based agriculture sector. Antibiotics, antibiotic-resistant bacteria (ARB), and related AMR genes (ARGs) are assumed to present in the natural environment and disseminate resistance to fresh produce/vegetables and thus to human health upon consumption. Therefore, this study aims to investigate the role of vegetables in the spread of AMR through an agroecosystem exploration from a One Health perspective in Ahmedabad, India. Protocol: The present study will be executed in Ahmedabad, located in Gujarat state in the Western part of India, by adopting a mixed-method approach. First, a systematic review will be conducted to document the prevalence of ARB and ARGs on fresh produce in South Asia. Second, agriculture farmland surveys will be used to collect the general farming practices and the data on common vegetables consumed raw by the households in Ahmedabad. Third, vegetable and soil samples will be collected from the selected agriculture farms and analyzed for the presence or absence of ARB and ARGs using standard microbiological and molecular methods. Discussion: The analysis will help to understand the spread of ARB/ARGs through the agroecosystem. This is anticipated to provide an insight into the current state of ARB/ARGs contamination of fresh produce/vegetables and will assist in identifying the relevant strategies for effectively controlling and preventing the spread of AMR.
Kultuuriline omastamine kultuurimuutusena / Modeling cultural appropriation as a kind of cultural change
Authors: Jackson Jason Baird 
Published: March 2023

The current article is an abridged and adapted version of Jason B. Jackson’s 2021 article On Cultural Appropriation, published in Journal of Folklore Research 58 (1), translated into Estonian by Elo-Hanna Seljamaa with the author’s permission. This article starts from the premise that cultural appropriation is a key concern for folklorists and ethnologists, as well as for many of the communities with which they engage and partner, but that it is also one that has received relatively little attention of a general conceptual sort. This is true despite the ubiquity of cultural appropriation discussions in popular media, public culture, and informal scholarly conversation. Drawing on the work of these fields, an ideal-type conceptualisation of cultural appropriation is offered, one that situates it as one among a range of modes of cultural change. For cultural appropriation, the key neighbouring modes are diffusion, acculturation, and assimilation (as shown in figure 1). This heuristic emphasises the metacultural discourse that marks instances of cultural appropriation as well as the inequality often characterising the parties to such episodes.
Keywords: cultural appropriation, ideal-type conceptualisation, inequality, cultural exchange
Haabjakultuuri kolm kogukonda / Three stakeholder communities of dugout canoes
Authors: Ruukel Aivar 
Published: March 2023

The skill of building dugout (alternatively: single-log) canoes (in Estonian: haabjas) is an important part of the intangible cultural heritage of Estonia’s Soomaa region and more generally of the Pärnu river basin. At the initiative of Estonian Dugout Canoe Society NGO (MTÜ Eesti Haabjaselts), the building of Soomaa dugout canoes has been included in the UNESCO Representative List of the Intangible Cultural Heritage of Humanity, in addition to Estonian national register of intangible cultural heritage. Soomaa dugout canoe building represents a broader tradition of dugout canoes shared by many Finno-Ugric peoples.
This initiative creates international collaboration opportunities between builders and popularizers of dugout canoes. Recognition of the dugout canoe tradition by UNESCO also supports cultural and nature turism in Soomaa National Park and helps to empower the local community of dugout canoe users, as well as pass the tradition of building dugout canoes to next generations.
In the brief overview, Aivar Ruukel, the spokesperson of the Estonian Dugout Canoe Society describes the three stakeholder communities of dugout canoes: the local inhabitants; the woodcraftsmen who have the skill of making the dugout canoes, and the international community of ancient boat enthusiasts.
Sõnastades sõnatut / Expressing tacit knowledge
Authors: Lüüs Urmas 
Published: March 2023

In his review of the Estonian translation of Richard Sennett’s The Craftsman, Urmas Lüüs, from the Estonian Art Academy, expresses his thoughts about the general position of ’material arts’ in the context of Estonian higher art education and the ways the book could help to cast new light on the forms of artistic self-expression that embrace making and skill besides conceptual ideas and design.
In addition to materiality and technical skills, tacit knowledge is another very important concept addressed by Sennett. Lüüs provides some contemporary examples where tacit knowledge is studied. Some attempts to re-evoke tacit knowledge may not be successful, because they have been passed literally from hand to hand, but the knowledge has perished alongside the growth of industrial production, much like it happened in metal casting for sculptures.
Lüüs points out that the book nicely pairs up with Jyrki Siukonen’s book Hammer and silence that was translated and published some years earlier and enjoyed very positive reception on behalf of art students. Both books show the way towards accepting the significance of (manual) skills in all types of creative activity.
Integrating postpartum IUD counselling and insertion into routine maternity care in Nepal: Assessing trends over time
Authors: Puri Mahesh Chandra , Guo Muqi , Stone Lucy , Shah Iqbal H. 
Published: March 2023

To meet the postpartum family planning (PPFP) needs of women in Nepal, an intervention was launched to integrate PPFP counselling and postpartum IUD (PPIUD) insertion into maternity care. Women delivering in study hospitals over a period of 18 months were interviewed at the time of delivery and at 15 months following the end of the study enrollment period to assess if the impact of the intervention observed at the end of the study was maintained. Data were collected prior to the intervention, at the middle month of the intervention roll out, at the end of the enrollment period and 15 months after the end of the enrollment period. We compared PPFP counselling and insertion rates before, during, at the end of and after the intervention study period, using cross-tabulation and chi-square tests. Overall, PPFP counselling rates increased from 11% at the baseline month to 45% at the end of the enrollment in February 2017 and remained the same 15 months later in July 2018. PPIUD uptake, however, rose from a negligible 0.1% at the baseline to 4.3% in February 2017, but declined to 3.4% in July 2018. PPIUD uptake among women who were counselled showed a similar trend, increasing from 1.9% at the baseline to 9.6% in February 2017 and declining to 6.0% in July 2018. The intervention had an appreciable continued impact on PPIUD counselling rates and although PPIUD uptake rose during the intervention, this trend was not observed in the 15 months post-study follow up. The impact of the intervention was greater and persistent in hospitals that had a longer period of exposure to intervention. The results suggest that counselling was well integrated with the maternity care, though uptake of PPIUD dropped after intervention activities such as active monitoring, technical supervision, provision of IUDs and training were withdrawn.
Trial registration: This study has been registered with Clinical Trial.gov. The registration number is NCT 02718222. Details about the study design have been published by Canning et al, 2016.
Live-in migrant home care workers in Germany: Stressors and resilience factors
Authors: Kriegsmann-Rabe Milena , Maus Katja , Hiebel Nina , Klein Constantin , Geiser Franziska 
Published: March 2023

Background
Thousands of Eastern Europeans find employment caring for older individuals as transmigrating live-in home care workers in private households in Germany. Studies have shown that the stressors threatening their well-being are multifaceted and include inequalities and a high practical and emotional workload, but research on protective factors is still scarce.

Aim & methods
This qualitative descriptive study focuses on both the stressors and factors that promote care workers’ well-being and contribute to their psychological resilience. In guideline-based interviews, 14 female and one male care workers were asked about their stressors and the factors that help them cope.

Results
Identified stressors included separation from their own family, strained relationship with either or both the care recipient (dementia) and their relatives (violation of worker´s rights and devaluation of care work), and permanent availability and lack of free time due to a 24-h care schedule. Resilience factors were both external and internal and included positive social relationships, self-determination, experience in care work, and intrinsic job motivation.

Conclusion
Live-ins reside in an ambiguous setting, exposed to both structural and individual strains. However, external and internal resilience factors contribute to a generally positive attitude toward their job and indicate the agency of this precariously employed group. A socially anchored appreciation of their work and an officially controlled expansion of free time are mandatory to improve the working conditions of live-in care workers.
Health progression for Covid-19 survivors hospitalized in geriatric clinics in Sweden
Authors: Kananen Laura , Hong Xu , Annetorp Martin , Mak Jonathan K. L. , Jylhävä Juulia , Eriksdotter Maria , Hägg Sara , Religa Dorota 
Published: March 2023

Objective
To analyse if the health progression of geriatric Covid-19 survivors three months after an acute Covid-19 infection was worse than in other geriatric patients. Specifically, we wanted to see if we could see distinct health profiles in the flow of re-admitted Covid-19 patients compared to re-admitted non-Covid-19 controls.

Design
Matched cohort study.

Setting and participants
Electronic medical records of geriatric patients hospitalised in geriatric clinics in Stockholm, Sweden, between March 2020 and January 2022. Patients readmitted three months after initial admission were selected for the analysis and Covid-19 survivors (n = 895) were compared to age-sex-Charlson comorbidity index (CCI)-matched non-Covid-19 controls (n = 2685).

Methods
We assessed using binary logistic and Cox regression if a previous Covid-19 infection could be a risk factor for worse health progression indicated by the CCI, hospital frailty risk score (HFRS), mortality and specific comorbidities.

Results
The patients were mostly older than 75 years and, already at baseline, had typically multiple comorbidities. The Covid-19 patients with readmission had mostly had their acute-phase infection in the 1st or 2nd pandemic waves before the vaccinations. The Covid-19 patients did not have worse health after three months compared to the matched controls according to the CCI (odds ratio, OR[95% confidence interval, CI] = 1.12[0.94–1.34]), HFRS (OR[95%CI] = 1.05[0.87–1.26]), 6-months (hazard ratio, HR[95%CI] = 1.04[0.70–1.52]) and 1-year-mortality risk (HR[95%CI] = 0.89[0.71–1.10]), adjusted for age, sex and health at baseline (the CCI and HFRS).

Conclusions and implications
The overall health progression of re-hospitalized geriatric Covid-19 survivors did not differ dramatically from other re-hospitalized geriatric patients with similar age, sex and health at baseline. Our results emphasize that Covid-19 was especially detrimental for geriatric patients in the acute-phase, but not in the later phase. Further studies including post-vaccination samples are needed.
Primary Pancreatic Undifferentiated Pleomorphic Sarcoma
Authors: Patel Mehrie Harshad , Guerrero Vinsard Daniela , Agrawal Upasana , Kendziora Ryan W. , Siontis Brittany L. , Swaroop Vege Santhi , Sweetser Seth 
Published: March 2023

ABSTRACT
Primary pancreatic sarcomas are rare malignancies with an incidence of 0.1%. This case report is of a 48-year-old man who presented with this condition. The patient's treatment plan consisted of distal pancreatectomy and splenectomy with intraoperative immunohistochemistry and adjuvant chemotherapy. To correctly identify and treat undifferentiated pleomorphic sarcoma, a stepwise strategy involving cross-sectional imaging and extensive histopathology analysis is necessary.
Probing motor dynamics at the muscle level—Acoustic myography in Parkinson's disease
Authors: Celicanin M. , Harrison A. P. , Kvistgaard Olsen J. , Korbo L. , Løkkegård A. , Danneskiold‐Samsøe B. , Siebner H. R. , Ilic T. V. , Bartels E. M. 
Published: March 2023

AbstractAcoustic myography (AMG) noninvasively probes muscle activity. We explored whether AMG captures abnormal motor activity in patients with Parkinson's disease (PD) and how this activity is modulated by antiparkinsonian medication. Twenty patients with PD underwent AMG of the biceps, triceps, extensor carpi radialis longus, and adductor policis muscles of the more affected arm during active and passive movements, using a mobile AMG device (CURO, Denmark). AMG and assessment of motor symptoms were performed in a pragmatic off‐medication state, as well as one and 3 h after oral intake of 200 mg levodopa. Three AMG parameters were calculated using the CURO analysis system. Motor efficiency was expressed by the E‐score, muscle fiber recruitment by the temporal T‐score, spatial summation by the S‐score, and S/T ratio. Twenty age‐ and sex‐matched healthy subjects served as controls. Group mean values were statistically compared using unpaired two‐tailed adjusted t‐test and ANOVA with Tukey´s correction for multiple comparison (p ≤ 0.05). For the biceps and extensor carpi radialis longus muscles, the active movement S:T ratio was lower in PD relative to healthy controls. The E‐score was also lower during active and passive flexion/extension movements in the off‐medication state. No significant between‐group differences in the AMG scores were noted for the triceps muscle during active or passive movements. The active S:T ratio and the E‐score during active elbow flexion and extension may offer a useful means to quickly assess abnormal motor activity and the effect of drug treatment in PD.
Groundstate for the Schrödinger-Poisson-Slater equation involving the Coulomb-Sobolev critical exponent
Authors: Lei Chunyu , Lei Jun , Suo Hongmin 
Published: March 2023

Abstract
In this article, we study the existence of ground state solutions for the Schrödinger-Poisson-Slater type equation with the Coulomb-Sobolev critical growth:

−
Δ
u
+

1

4
π
∣
x
∣

∗
∣
u

∣

2

u
=
∣
u
∣
u
+
μ
∣
u

∣

p
−
2

u
,

in

R

3

,

-\Delta u+\left(\frac{1}{4\pi | x| }\ast | u{| }^{2}\right)u=| u| u+\mu | u{| }^{p-2}u,\hspace{1.0em}{\rm{in}}\hspace{0.33em}{{\mathbb{R}}}^{3},

where

μ
>
0

\mu \gt 0

and

3
<
p
<
6

3\lt p\lt 6

. With the help of the Nehari-Pohozaev method, we obtain a ground-state solution for the above equation by employing compactness arguments.
Efficiency evaluation of a SARS-CoV-2 diagnostic strategy combining high throughput quantitative antigen immunoassay and real time PCR
Authors: Bernasconi Luca , Neyer Peter , Oberle Michael , Schmid Bettina , Martin Eileen , Fankhauser Hans , Haubitz Sebastian , Hammerer-Lercher Angelika 
Published: March 2023

Abstract

Objectives
Laboratory testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has played an important role in the effort to prevent and contain local outbreaks. The aim of this study was to assess the diagnostic accuracy of a new fully automated SARS-CoV-2 laboratory-based antigen assay (CoV2Ag) and to explore the efficiency of a diagnostic algorithm combining antigen and conventional high-throughput molecular assays to address potential future challenges of the SARS-CoV-2 pandemic.

Methods
One thousand two hundred and twenty four consecutive nasopharyngeal swabs were tested using RT-PCR and CoV2Ag assay.

Results
The overall sensitivity and specificity of CoV2Ag were 79.1 and 97.8%, respectively. When the analysis was restricted to cases with Ct values ≤30, the sensitivity of the assay improved to 98.1%. Acceptable sensitivity was found when the analysis was limited to patients presenting within one or two to four days of symptom onset (80.5 and 84.8%, respectively). A retrospective analysis of the use of a two-step diagnostic approach combining the CoV2Ag assay and RT-PCR during an acute pandemic phase of 97 days showed a potential reduction in the number of RT-PCR tests by 36.1%, corresponding to savings in reagent costs and technician workload of approximately €8,000 and 10.5 h per day, respectively.

Conclusions
Our data show that the proposed algorithm represents a valid alternative diagnostic approach to increase testing efficiency during future pandemic phases with high positivity rates (>20%) and elevated numbers of RT-PCR test requests.
Internet, studying and daily rhythm: health symptoms among higher education students
Authors: Rouvinen Hanna , Sormunen Marjorita , Kunttu Kristina , Turunen Hannele 
Published: March 2023

Abstract

Objectives
Excessive Internet use is a health concern among higher education students leading to reduced academic performance and problems in everyday life. This study aimed to explore the relationship between health and problems of studying and daily rhythm caused by time spent online among students (n=3,050).

Methods
A cross-sectional survey was carried out. The data were analyzed using descriptive and chi-square tests and logistic regression analyses.

Results
Findings indicated that one fifth of students reported having problems of studying and daily rhythm caused by time spent online. Psychological health symptoms such as anxiety (p<0.001) and physical health symptoms including lower back problems (p<0.001) were associated with these problems. According to the logistic regression analyses, problems of studying and daily rhythm caused by time spent online and higher amount of Internet use by time were associated with psychological and physical health symptoms.

Conclusions
The findings suggest that problems of studying and daily rhythm and spending more time online are related to health symptoms among the students. The study’s findings can be used from a prevention standpoint for early identification and further to identify the need for seeking professional treatment.