bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram model based on neuroendocrine markers for predicting the prognosis of neuroendocrine carcinoma of cervix
Authors: Jia Mingzhu , Pi Jiangchuan , Zou Juan , Feng Min , Chen Huilin , Lin Changsheng , Yang Shuqi , Deng Ying , Xiao Xue 
Published: January 2023

Abstract
Purpose
Combining traditional clinical parameters with neuroendocrine markers to construct a nomogram model to predict the postoperative recurrence of neuroendocrine carcinoma of cervix (NECC).
Methods
257 patients were included in this study, of which, 171 patients diagnosed with NECC who underwent surgery at West China Second Hospital of Sichuan University were considered as part of the training cohort. The univariate and multivariate Cox regression analyses were used in screening the high-risk factors related to cancer recurrence in the training cohort to establish a nomogram model which was further independently validated in the remaining 86 patients who underwent surgery at First Affiliated Hospital of Chongqing Medical University. The calibration curve was used to conduct the internal and external verification of the model.
Results
Overall, 41 relapse cases were observed in the training (23 cases) and validation (18 cases) cohorts. The univariate analysis preliminarily showed that FIGO stage, stromal invasion, nerve invasion, lymph vascular space invasion, lymph node involvement, cervical-uterine junction invasion and CgA were correlated with NECC recurrence. The multivariate analysis further confirmed that FIGO stage (P = 0.023), stromal invasion (P = 0.002), lymph vascular space invasion (P = 0.039) and lymph node involvement (P = 0.00) were independent risk factors for NECC recurrence, which were ultimately included in the nomogram model. In addition, superior consistency indices were demonstrated in the training (0.863, 95%CI 0.784–0.942) and validation (0.884, 95%CI 0.758–1.010) cohorts.
Conclusion
The established nomogram model combining traditional clinical parameters with neuroendocrine markers can reliably and accurately predict the recurrence risks in NECC patients.
The Ross-Mcdonald model revisited: linking transmission and within-host dynamics
Authors: López Mayra Núñez , Echeverría Jocelyn Anaid Castro , Hernández Jorge Xicoténcatl Velasco 
Published: January 2023

Abstract
We present a model that explicitly links the epidemiological Ross-Macdonald model with a simple immunological model through a virus inoculation term that depends on the abundance of infected mosquitoes. We explore the relationship between the reproductive numbers at the population (between-host) and individual level (within-host), in particular the role a certain measure of infectivity (defined in terms of the number of target cells infected) and viral clearance rate play in the coupled dynamics. The conditions for a disease outbreak require, for the average individual in the population, to have an active (within-host) viral infection. This infection depends on the viral load and the proportion of infected cells which are quantities that change in time. Only when these two quantities are sufficiently large, the epidemic outbreak may occur. We also describe a particular kind of transmission-clearance trade off for vector-host systems with a simple structure.
On-orbit Geometric Calibration Method Based on Star Observation to Correct Thermal Deformation of GEO Optical Satellite
Authors: Huang Jie , Xi Juntong , Wu Yayun 
Published: January 2023

Abstract
The thermal environment in geostationary orbit is much complicated than low orbit. Thermal deformation is a primary factor to deteriorate geometric quality of remote sensing image of geostationary optical satellite. The on orbit geometric quality testing results of the SDLT-1 satellite of China show that the light of sight (LOS) deviation in longitude and latitude are 26 pixels and 14 pixels respectively which are out of the accuracy requirement of the satellite. Therefore a novel on-orbit geometric calibration method based on star observation is proposed to correct thermal deformation of geostationary optical satellite. The images embodied stars are employed as experiment sources to evaluate the proposed method which are compared with traditional method based on landmarks. The results show that the geometric accuracy of the proposed method can achieve 3.2 pixels which are better than traditional calibration method based on landmarks.
Prognostic Biomarkers Based On GUF1, EFTUD2 and GSPT1 Targets Affecting Migration of Gastric Cancer Cells.
Authors: Ma Haixiu , Wang Xiaowu , Zhao Jing , Ma Ronghua , Wang Qi , Liu Jun , Qiao Jinwan , Wu Juan , An Juan , Liu Yan , Xing Yonghua , Ma Xueman , Wu Qiong , Wang Haiyan , Su Zhanhai 
Published: January 2023

Abstract
Eukaryotic Elongation Factor 1 Alpha 2 (EEF1A2) is a protein coding gene which involved in tumor development and progression in several types of human cancer, but little is known about the function of EEF1A2 proteins in gastric cancer (GC).The ONCOMINE and the TCGA databases were used to evaluate the expression of GUF1, EFTUD2, GSPT1 and GSPT2 in GC and the association of EEF1A2 family with individual clinical characteristics. Kaplan-Meier (K-M) Plotter hint the prognostic value of GUF1, EFTUD2, GSPT1 and GSPT2. GSE62254 and GSE66222 dataset were used to validated the expression of GUF1, EFTUD2, GSPT1. Human AGS and GES cells lines were also used for validating the function of GUF1, EFTUD2, GSPT1. RNA interference (RNAi) of GUF1, EFTUD2 and GSPT1 have been used to query those genes expression pattern and dissect the proliferation and migration in GC cells line. The results showed that GUF1, EFTUD2 and GSPT1 were significantly up-regulated in GC cell lines. High expression of GUF1, EFTUD2 and GSPT1 was correlated with cell proliferation and migration induced in GC cells. We report GUF1, EFTUD2 and GSPT1 may be potential novel oncogenes that helps to maintain the survival of GC cells. Our study identified that high level of GUF1, EFTUD2 and GSPT1 expression are predictive biomarkers for a poor prognosis in GC.
Healthcare Workers’ Delivery of Adolescent Responsive Sexual and Reproductive Healthcare Services: An Assessment in Plateau State, Nigeria
Authors: Envuladu Esther Awazzi , Massar Karlijn , de Wit John 
Published: January 2023

Abstract
Background
Adolescents should have access to high quality and responsive sexual and reproductive health services (SRHS), and recently, in Nigeria a national policy on the health and development of adolescent and young people was developed to ensure adolescents’ sexual and reproductive health needs will be met. However, it is unclear to what extent the policy is implemented by healthcare workers (HCW’s) in health facilities across the country. The current study assessed the general availability of SRHS and the delivery of SRHS to adolescents in primary care facilities from the perspective of HCW. We also assessed HCWs views of facilities meeting the SRH needs of adolescents, and their understanding of what constitutes adolescent responsive SRHS.
Methods
Using a cross sectional design, we included 409 HCWs selected by multistage sampling technique, mostly females (66.3%) and above 40 years, across six Local Government Areas (LGAs) of Plateau State, Nigeria and interviewed them using an interviewer-administered survey questionnaire.
Results
The most frequently available SRHS was antenatal and delivery care (69.2%). Availability of contraception was reported by 25.9%, and 14.9% reported the availability of post abortion care. Only 1.2% indicated that all four SRHS recommended for adolescents (counselling/information provision, provision of contraceptives, testing/treatment for sexually transmitted infection (STI) /HIV, and post abortion care) were available. Little over half (58.4%) felt their facilities were adequate in meeting the SRH needs of adolescent, and this was associated with duration of working experience (AOR = 0.407; CI = 0.238–0.698; p = .001), delivery of post abortion care (AOR = 3.612; CI = 1.886–6.917; p = .001), and providing SRHS to adolescents without parental consent (AOR = 3.612; CI = 1.886–6.917; p = .001). Most HCWs had poor understanding of adolescent responsiveness of SRHS, and better understanding was associated with lower HWC’s age, and also better among HCWs who provided SRHS without parental consent and in a separate room for privacy and confidentiality.
Conclusion
We conclude that ASRHS is not yet as stipulated in the national policy in Plateau State, Nigeria and HCW’s perception of their services being adolescent responsive was higher when they actually delivered relevant ASRHS. In general they have poor understanding of what it means to provide adolescent-responsive services.
Prevalence of potato blackleg and soft rot in Georgia
Authors: Muradashvili Maka , Tsror Leah , Sikharulidze Zoia , Meparishvili Soso , Sara Lebiush Mordechai , Meparishvili Galina 
Published: January 2023

Abstract
Potato is an important commodity in Georgia, but the average yields are considerably low (12 t/ha) mainly due to bacterial diseases. During 2020-2021, 73 samples of diseased potato tubers and stems were collected from fields and storage facilities, in different locations in Georgia. Following microbiological and biochemical tests, 54 strains (74%) were gram-negative, facultative anaerobic, oxidase negative, catalase-positive, they developed at 37oC and in 5% NaCl, non-fluorescent on King´s B medium, and produced cavities on CVP, thus indicating they were either Dickeya or Pectobacterium spp. Twenty-seven out of selected 33 strains were identified as Dickeya spp. using conventional PCR and 21 of them were further characterized as D. solani (using TaqMan RT-PCR). According to the present research, D. solani is the major pathogen associated with potato soft rot and black leg in different regions of Georgia. The most prevalent species in Europe, P. brasiliense, as well as D. dianthicola have not been detected in the current research.
Time to death and its predictors among asphyxiated neonates admitted to Jimma University Medical Center, Ethiopia: a retrospective cohort study
Authors: Kajela Lencho , Berhanu Solomon , Kune Guta , Gezahegn Yenealem 
Published: January 2023

Abstract
Background
Perinatal asphyxia is the second leading cause of neonatal mortality in sub-Saharan African countries. Preterm birth complications, perinatal asphyxia, and infection account for greater than 80% of neonatal mortality in Ethiopia. There is limited study in Ethiopia on the survival status of asphyxiated neonates; therefore, this study aimed to assess time to death and its predictors among asphyxiated neonates admitted to Jimma University Medical center.
Methods
A retrospective cohort study was conducted on all eligible 373 asphyxiated neonates admitted to Jimma University Medical Center from April 12/2019 to May 5 /2022. Data were extracted from May 18 to June 3/2022, entered into Epidata 3.1, and analyzed by R 4.2.1. Bivariable Cox regression was used to select candidate variables for Multivariate cox regression. Multivariate cox regression was fitted to identify predictors of time to death of the neonates at 0.05 level of Significance and corresponding confidence interval of the adjusted Hazard ratio.
Results
in this study, 84(22.52%( 95CI:18.38–27.10))) neonates died during 2888 person days, yielding an incidence rate of 29.09 (95%CI: 23.20-36.01) per 1000 person-days. The median survival time was 20 days (95%CI: 18–23)). Stage III Hypoxic ischemic encephalopathy (AHR: 3.46(95%CI: 1.55–7.70)), acute kidney injury (AHR: 2.82 (95%CI: 1.28–6.23)), and stress ulcers (AHR: 2.24 (95%CI: 1.26–3.97)) were independent predictors of time to death.
Conclusions
The incidence of neonatal mortality was high; therefore, early identification of the stage of Hypoxic ischemic encephalopathy, acute kidney injury, stress ulcers, and close follow-up is suggested.
A semi-Markov model with geometricrenewal processes
Authors: Zhang Jingqi , Fouladirad Mitra , Limnios Nikolaos 
Published: January 2023

Abstract
We consider a system modeled by a semi-Markov process where we include geometric renewal process for sojourn times. Pérez-Ocón and Torres-Castro first study this system [1]. In our work here we consider an extended state space for up and down times separately. This allows us to use the standard theory for semi-Markov processes in order to obtain all reliability related measurements as reliability, availability (point and steady-state), mean times and rate of mortality of the system with general initial law. We proceed with a convolution algebra, which allows us to obtain final closed form formulas for the above measurements. Moreover, we present numerical examples.
Plant growth promoting bacteria mitigates salt stress during Handroanthus impetiginosus in vitro rooting
Authors: Yarte Mauro Enrique , Gonzalez Ana Julia , Llorente Berta Elizabet , Larraburu Ezequiel Enrique 
Published: January 2023

Abstract
Salinity is one of main abiotic stresses that causes adverse effects on plant growth and affects millions of hectares around the world. Variability of physical and chemical properties of soils has made field experiments notoriously difficult to evaluate. Plant tissue culture has been used as a model system to study physiological responses induced by salinity. The aim of this work was to evaluate the tolerance to salinity of Handroanthus impetiginosus ‘pink lapacho’ and the effect of inoculation with plant growth-promoting bacteria previously isolated from adult plants. Shoots induced for 3 days in half-strength Murashige and Skoog medium with 30 µM of indole butyric acid were used and then transferred to auxin-free medium, supplemented with 0, 40, 80 or 160 mM NaCl and inoculated or not with 108 cfu of Bacillus sp. L15 or Sphingobacterium sp. L22. At the end of experiments (40 days), 50% Inhibitory Concentration 50 (IC50) was determined from regression curves constructed with rooting percentages. Bacterization with L15 and L22 strains displaced IC50 to higher NaCl concentrations (147 and 160 mM, respectively) relative to controls (109 mM). Furthermore, inoculation with L22 improved biometric parameters index (BPI) at 40 mM NaCl. Finally, bacterization and NaCl concentration modified proline, phenolics and chlorophylls contents during the first 15 days of culture. Bacteria inoculation also mitigated anatomical alterations produced by salt stress. In conclusion, bacteria tested in this work promoted in vitro rooting and alleviated negative effects from salt stress in H. impetiginosus.
Facile synthesis of few-Layered MoS2 Nanoroses Covering TiO2 Nanowires as improved bacterial inactivation and photodegradation devices
Authors: Allahyar Soheil , Taheri Milad , Allahyar Sina 
Published: January 2023

AbstractRecently, much attention has been paid to heterogeneous nanostructures. Its versatile properties include morphology stimulants, surface oxygen vacancies, and chemical compounds to enhance the production of reactive oxygen species. In addition, phase junction construction and surface modification are two practical engineering strategies toward efficient photocatalysis. In this study, a novel and efficient TiO2-MoS2hybrid structure photocatalyst has been fabricated through microwave irradiation method. Investigation of the phase, structural, morphological and optical properties of nanohybrids were determined by X-ray diffraction (XRD), scanning electron microscopy (SEM), UV-Vis absorption;Fourier transform infrared (FTIR). Interlacment few layers MoS2and distribution MoS2nanoroses (NRs) on TiO2nanowire (NWs) have been carefully evaluated from HRTEM images. The amount of photodegradation of methylene blue (MB) solution was investigated using UV visible absorption spectroscopy. According to the results, TiO2-MoS2hybrids were effective in the photodegradation of methylene blue under visible light irradiation. Here, the photodegradation efficiency of the nanohybrids after 60 minutes of irradiation time was about 96% with a reaction rate of 3.34 x 10− 3min− 1. The electron trapping recombination and acceptable photocatalytic mechanism have also been investigated, and the reported work could be promising as an efficient photocatalyst for industrial wastewater treatment. The photocatalytic antibacterial activity of the nanohybrids was estimated to kill 98% of E. coli in 60 minutes, so they are excellent in water disinfection.
Gender-specific associations between weight-adjusted-waist index and peripheral arterial disease in adults: Evidence from NHANES 1999-2004
Authors: Xie Feng , Gong Ren , Fang Haiyang , Xu Jinsong , Wu Yanqing 
Published: January 2023

Abstract
The relationship between weight-adjusted-waist index (WWI, a newly developed obesity index) and peripheral arterial disease (PAD) is unclear. We aimed to explore the association between WWI and the prevalence of PAD in US adults. A total of 7,344 participants (males: 50.60%; females: 49.40%) from the 1999–2004 National Health and Nutrition Examination Survey (NHANES) were included in this study. WWI was calculated as waist circumference (WC) divided by the square root of weight. PAD was defined as an ankle-brachial index < 0.90 in either leg. The prevalence of PAD was 7.84%, which was respectively 3.72%, 7.23%, and 12.58% in WWI tertiles 1–3 (P < 0.001). WWI was positively associated with an elevated likelihood of PAD (OR = 1.25, 95% CI: 1.06–1.48), and the association was robust in stratified subgroups (all P for trend > 0.05). For male participants, there was a nearly linear relationship between WWI and PAD (OR = 1.35, 95% CI: 1.01–1.82). However, non-linear positive relationships were detected in females with an inflection point of 10.98 cm/√kg. A positive association was observed on the left of the inflection point (OR = 2.71, 95% CI: 1.27–5.78), while the association on the right was of no statistical significance (OR = 1.01, 95% CI: 0.77–1.33). In summary, WWI was significantly associated with an increased likelihood of PAD in US adults, with a differential association between males and females.
Glutathione Trisulfide Prevents Lipopolysaccharide-induced Retinal Inflammation via Inhibition of Proinflammatory Cytokine Production in Glial Cells
Authors: Tawarayama Hiroshi , Umeki Kota , Inoue-Yanagimachi Maki , Himori Noriko , Takahashi Naoki , Tsuda Satoru , Kunikata Hiroshi , Akaike Takaaki , Nakazawa Toru 
Published: January 2023

Abstract
We aimed to investigate the impact of glutathione trisulfide (GSSSG) on lipopolysaccharide (LPS)-induced inflammation in retinal glia. Inflammatory responses in mouse-derived glial cells and Wistar rat retinas were stimulated with intravitreal LPS injection. Cell survival and proinflammatory cytokine production were examined using the Calcein-AM assay, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Retinal microglia were visualized with immunohistochemistry for Iba1. Administration of LPS (10 µg/mL) or GSSSG (less than 100 µM) did not affect survival of cultured primary Müller cells and established microglial cells. RT-qPCR and ELISA indicated that GSSSG inhibited LPS-induced gene upregulation and protein secretion of proinflammatory cytokines in these glial cells and rat retinas. Finally, immunohistochemical studies indicated that GSSSG inhibited LPS-induced accumulation of Iba1-immunopositive microglia in rat retinas. GSSSG has the potential to prevent pathogenesis of inflammation-associated ocular diseases by inhibiting proinflammatory cytokine expression in retinal glial cells.
Retrospective analysis of 21 cases of Marchiafava-Bignami disease in alcoholic in Southwest China
Authors: Wu xiaohui , Li Wenju , Wang Yuzhu , Chen Xuan , Xi Zhi-Qin 
Published: January 2023

Abstract
Marchiafava-Bignami disease (MBD) is a rare disease with only a few reports worldwide. To describe clinical features and identify difficulties in the treatment of alcohol-related MBD, we performed a retrospective study of 21 MBD inpatients at a hospital in Southwest China. The interquartile range (IQR) for age was 53-66, with a mean age of 59 years. The IQR for drinking duration was 30-40, with a mean drinking length of 35.5 years. Cognitive impairment and unconsciousness were the most common symptoms (n=13, [61.9%]). Consciousness disorders, delirium, irritability, and ataxia are more prevalent in type A MBD patients; seizures, cognitive impairment, and limb weakness are more common in type B MBD patients. Routine blood and biochemical tests in alcoholic MBD patients may demonstrate orthocytic hypochromic anaemia and impaired liver function. Patients' uric acid (UA), potassium, and sodium levels may be normal. Eight patients received thiamine, while one received steroids. The average stay was 15 days. At the time of discharge, there had been no deaths. One patient died six months after being discharged, while another died two years afterwards. Indeed, MBD is a rare alcohol-related disorder with a variety of clinical symptoms. With thiamine treatment, prognosis is positive.
Clinical Implications of Fractional Flow Reserve Measured Immediately after Percutaneous Coronary Intervention
Authors: Csanadi Bettina , Ferenci Tamas , Fulop Gabor , Piroth Zsolt 
Published: January 2023

Abstract
Purpose
The purpose of the present study was to find the independent predictors of Fractional Flow Reserve (FFR) measured immediately after percutaneous coronary intervention with drug eluting stent implantation (post-PCI FFR) and investigate if applying vessel-specific post-PCI FFR cut-off values to predict target vessel failure (TVF), a composite of cardiac death (CD), non-fatal myocardial infarction (MI) and target vessel revascularisation (TVR) or a composite of CD and MI ameliorated its predictive power.
Methods
Consecutive patients with post-PCI FFR measurement at our center between 2009 and 2021 were included in this analysis.
Results
434 patients with 500 vessels were included. Median pre-PCI FFR was 0.72 with no difference between LAD and non-LAD vessels. Median post-PCI FFR was 0.87. LAD location, male gender, smaller stent diameter and lower pre-PCI FFR proved to be significant predictors of a lower post-PCI FFR. On a vessel-level, post-PCI FFR, stent length, and diabetes mellitus proved to be significant predictors of TVF and the composite of CD and MI. The best post-PCI FFR cut-off to predict TVF or a composite of CD and MI was 0.83 in the LAD and 0.91 in non-LAD vessels.
Conclusion
LAD location is a predictor of a lower post-PCI FFR. Post-PCI FFR is an independent predictor of TVF as well as of the composite of CD and MI. No uniform target post-PCI FFR value exists; different cut-off values should be applied in LAD as opposed to non-LAD vessels.
Pd decorated ZnO nanosheets for enhanced hydrogen sensing performance
Authors: Dong Hua-Dong , Zhao Jian-Ping , Peng Ming-Xing , Xu Pei-Yuan , Yang Xuan-Yu , Zhang Yong-Hui 
Published: January 2023

AbstractWith the exhaustion of fossil energy, hydrogen (H2), as a kind of clean energy with extensive source and high calorific value, has attracted great attention. However, in the process of H2preparation, transportation and storage, safety accidents such as leakage and explosion often occur, which greatly hinders the development and utilization of H2. Therefore, fast and accurate detection of H2plays an important role in H2industry. Based on this, we have synthesized two-dimensional (2D) zinc oxide (ZnO) nanosheets by hydrothermal method, and further optimized its sensing performance through Pd modification. H2sensitivity test results show that Pd load can greatly enhance the sensing performance of 2D ZnO materials. At 160°C, the sensing response of Pd load ZnO sensitive materials (PZO) towards H2(100 ppm) is 17.6, which is much higher than the pure ZnO nanosheets (3.2). Additionly, the H2sensing performance of the prepared gas sensor did not change significantly during the 30-days test, showing excellent stability. The H2sensing mechanism of PZO sensitive materials is mainly attributed to the synergistic mechanism of Pd catalytic site and oxygen vacancy (OV). Therefore, the synthesized PZO sensitive material provides an effective strategy for the preparation of high-performance H2sensors.