bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lima Puluh Tiga Tahun Penelitian dan Pengembangan Lahan Rawa untuk Pertanian dan Produksi Pangan
Authors: Noor Muhammad , Sukarman Sukarman , Masganti Masganti , Hairani Anna , Khairullah Izhar , Alwi Muhammad 
Published: February 2023

<p>Masa depan pangan Indonesia ada di lahan rawa. Pembukaan rawa untuk produksi pangan oleh pemerintah melalui Proyek Pembukaan Persawahan Pasang Surut (P4S) tahun 1969-1984 yang disebut sistem reklamasi garpu dan sisir membawa Indonesia swasembada tahun 1985, sekalipun pasokan utama produksi dari lahan irigasi. Disusul Proyek Pengembangan Lahan Gambut (PLG) di Kalimantan Tengah tahun 1995-1999 bersamaan saat impor beras 2-3 juta ton per tahun, namun kemudian, di tengah kecaman, Proyek PLG dihentikan pada tahun 1999. Pandemik Covid 19 membuat pemerintah menginisiasi pengembangan <em>Food Estate</em> lahan rawa di Kalimantan Tengah tahun 2021-2023. Luas lahan rawa sekitar 32,64-33,39 juta hektar, diantaranya 14-19 juta hektar sesuai untuk pertanian. Hanya saja baru 6,90 juta hektar yang dimanfaatkan diantaranya 2,90 juta hektar untuk padi dan masih tersedia seluas 27,60 juta hektar yang belum direklamasi dari luas total rawa dan 0,84 juta hektar yang belum dimanfaatkan dari 2,90 juta hektar yang telah direklamasi. Produktivitas padi di lahan rawa yang dicapai petani masih rendah (2-3 t/ha)sementara dari hasil penelitian mencapai 4,5-7,5 t/ha. Kendala budidaya padi di lahan rawa antara lain kemasaman tanah yang tinggi, kualitas air jelek, unsur dan senyawa toksik, kahat hara makro dan mikro, serangan hama dan penyakit tanaman. Pendekatan pengembangan rawa memerlukan penanganan yang terpadu dan spesifik lokasi. Implementasi program yang dilaksanakan pemerintah memberikan pelajaran bahwa pengembangan pertanian, khususnya padi memerlukan dukungan infrastruktur tata air, perencanaan sistem produksi, kelembagaan manajemen, dan langkah implementasi yang cepat dan tepat. Beberapa catatan menunjukkan pendekatan pengelolaan masih bersifat parsial, tidak terintegrasi, tanpa <em>road map</em> dan target yang jelas, manajemen dan kelembagaan petani masih lemah, sehingga dampak terhadap kesejahteraan petani masih belum tercapai. Tulisan ini mengemukakan tentang perjalanan penelitian dan pengembangan lahan rawa selama 53 tahun meliputi dinamika kegiatan pengembangan, peluang, kendala dan pembelajaran dari petani pada pengembangan kawasan <em>food estate</em> di Kalimantan Tengah. </p>
Temperature-Transient Analysis for Matrix Linear Flow Toward Infinite-Conductivity Hydraulically Fractured Wells
Authors: Onur Mustafa , Gul Kiymet Gizem , Cinar Murat 
Published: February 2023

SummaryThis work presents novel analytical temperature-transient solutions for matrix linear flow toward an infinite-conductivity hydraulically fractured well producing under specified constant rate (CR) or constant bottomhole pressure (CBHP) production. The solutions apply to the single-phase flow of a slightly compressible fluid with constant viscosity (e.g., undersaturated oil reservoirs with irreducible water saturation or liquid-dominated geothermal reservoirs). They include the effects of conduction, convection, the Joule-Thomson (J-T) expansion of fluids and adiabatic expansion of the total rock and fluid system, and fluid loss fracture damage and assume constant rock and fluid physical and thermophysical properties with pressure and temperature. They are obtained by using Laplace (for CR) and Boltzmann (for CBHP) transformations. To validate the analytical solutions, an in-house numerical solution is also developed. It solves the mass and thermal energy balance equations coupled simultaneously and accounts for the variation of rock and fluid properties with pressure and temperature. The in-house simulator was validated by using a commercial reservoir simulator. Results indicate that the fracture surface temperature is decreasing with a square root of time for CR production but is constant for CBHP production. The temperature responses for both modes of production are controlled by the adiabatic expansion of the rock and fluid properties and the thermal diffusivity of the rock. The effect of thermal conductivity plays a significant role in both production modes as the matrix permeability decreases. The fracture damage has different signatures on temperature transients depending on the mode of production. The approximate analytical solutions show the information content of temperature-transient data acquired from an infinitely conductive hydraulically fractured well under matrix linear flow. They are simple and can be used to perform matrix linear-flow analysis jointly with pressure and rate transient data to estimate the physical and thermophysical properties of the rock and fluids. We also propose a simple correction to fluid viscosity variation as input for the analytic solutions to accurately estimate the physical and thermophysical parameters in case drawdowns are significant.
Inertial effects in just-saturated axisymmetric column collapses
Authors: Webb William , Heron Charles , Turnbull Barbara 
Published: February 2023

Abstract
This work introduces a scaling analysis of sub-aerial axisymmetric column collapses of glass beads and Newtonian glycerol-water solutions mimicking some of the behaviours of debris flows. The beads were in a size range where their inertia partly decouples their collapse behaviour from the water column. Experiments explored a range of viscous, surface tension and particle inertia effects through systematic variation of particle size and fluid viscosity. Crucially a geotechnical centrifuge was used to access elevated effective gravitational accelerations driving the collapse, allowing field-scale viscous and surface tension effects to be replicated. Temporal pore pressure and runout front position evolution data was extracted using a pressure transducer and high speed imaging, respectively. A least-squares fitted scale analysis demonstrated that all characteristic dimensionless quantities of the acceleration phase could be described as a function of the column-scale Bond number Bo, the Capillary number Ca, the system size r*, and the grain-fluid density ratio ρ*. This analysis demonstrated that collapses as characterised by pore-pressure evolution and front positions were controlled by the ratio of Bo/Ca. This indicates that grain-scale surface tension effects are negligible in such inertial column collapses where they may dominate laboratory-scale granular-fluid flow behaviour where geometric similarity between grain and system size is preserved.
Efficacy of pharmacological and non-pharmacological therapy on pain intensity and disability of older people with chronic nonspecific low back pain: a protocol for a network meta-analysis
Authors: Fonseca Letícia Soares , Silva Juliana , Souza Mateus , Mascarenhas Rodrigo , Silva Hytalo , Campos Mariana , Pereira Leani , Oliveira Murilo , Oliveira Vinicius 
Published: February 2023

Abstract
Background
The purpose of this network meta-analysis (NMA) is to investigate the efficacy of pharmacological and non-pharmacological therapy on pain intensity and disability of older people with chronic nonspecific low back pain, providing comprehensive evidence for an informed decision making.
Methods
We will perform a systematic search to identify randomized controlled trials of pharmacological and non-pharmacological interventions for older people with chronic nonspecific low back pain. MEDLINE, COCHRANE LIBRARY, EMBASE, AMED, PSYCINFO and PEDRO will be searched without language or date restrictions. Our primary outcomes are pain intensity and disability. Risk of bias will be assessed for all studies using the revised Cochrane Risk of Bias (RoB) tool 2.0. For each pairwise comparison between the different interventions, estimated mean differences and their 95% confidence intervals will be presented. Standard pairwise meta-analyses will be performed using random effects models in STATA version 16. The competing interventions will be ranked using the surface under the cumulative ranking curve (SUCRA) for the outcomes of interest at short- and long-terms. The confidence in the results from NMA will be assessed using the Confidence in Network Meta-analysis (CINeMA) framework.
Discussion
This NMA compares efficacy of interventions for nonspecific chronic low back pain in older people. It will provide reliable evidence for patients, clinicians, stakeholders and researchers in this field where competing therapies, many of extraordinarily little value, are commonly used in clinical practice.
Systematic review registration:
OSF (DOI: 10.17605/OSF.IO/4W6R5) and registered in the PROSPERO database (CRD42022312565).
Key factors for teaching and learning – Teachers´ experiences and reflections
Authors: Tjernberg Catharina Cecilia 
Published: February 2023

Abstract
A group of students were fol­lowed in a longitudinal study through­out their com­pul­sory school years. The data collec­ted formed the starting point for a focus-group discussion, the results of which are re­por­ted and discussed in the article.
The aim is to investigate the factors that the teachers consider have, over the years, been important for the students’ learning process, and to reflect on what char­acterises teaching practices that promote participation and learn­ing. The re­sults show that the most important factor in a successful teacher’s work is her or his ability to meet the students according to their individual needs; this also in­volves using the student group as a learning resource and ad­opt­ing a critical at­ti­tude to one’s own teaching with the aim of develop­ing it. At­titude, high ex­pec­ta­tions and a positive belief in the students are key factors here, as well as the abil­i­ty to stage well-balanced teaching with a fo­cus on content, language, and lan­guage use.
The importance of collegial learning for the professional development of teach­ers is em­phasised, as is the value of enjoying one’s work and sharing both successful and not so successful pedagogical episodes. One sur­pris­ing res­ult is the teachers’ con­scious efforts to help the students adopt strategies for learn­ing.
A Time-Varying Study of Fundamental values relative to the share price and Solvency and Liquidity on Stock Returns in India
Authors: Wagle Namrata , Khanapuri Harip 
Published: February 2023

Abstract
This research investigates the relationship between firm-specific style attributes and the cross-section of equity returns on the National Stock Exchange in India over the period from March 2001 to March 2021. The linear expected returns forecasting model is constructed based on the cross-section of equity returns. The model identifies the Cash Flow to Current Liabilities Ratio and the Current Ratio as significant style attributes that distinguish future share returns on the NSE. The results of the research provide potential alpha-generating stock selection techniques for active portfolio managers in the Indian stock markets using the linear approach.
An open-label randomised controlled trial evaluating the efficacy of a meningococcal serogroup B (4CMenB) vaccine on Neisseria gonorrhoeae infection in gay and bisexual men: the MenGO study Protocol
Authors: Thng Caroline , Semchenko Evgeny A. , Hughes Ian , O'Sullivan Maree , Seib Kate L. 
Published: February 2023

Abstract
Background: Gonorrhoea is an ongoing public health concern due to its rising incidence and the emergence of antibiotic resistance. There are an estimated 82 million new Neisseria gonorrhoeae infections each year, with several populations at higher risk for gonococcal infection, including gay and bisexual men (GBM). If left untreated, infection can lead to serious morbidity including infertility, sepsis and increased risk of HIV acquisition. Development of a gonorrhoea vaccine has been challenging, however there is observational evidence that serogroup B meningococcal vaccines, used to protect against the closely related bacteria Neisseria meningitidis, could provide cross-protection against N. gonorrhoeae.
Methods: The MenGO (Meningococcal vaccine efficacy against Gonorrhoea) study is a phase III open-label randomised control trial in GBM to evaluate the efficacy of the four-component meningococcal serogroup B vaccine, 4CMenB, against gonorrhoea. A total of 130 GBM will be recruited at the Gold Coast Sexual Health Clinic, Australia, and randomised to either receive 2 doses of 4CMenB or no intervention. Participants will be followed up for 24 months with testing for N. gonorrhoeae and other sexually transmissible infections every three months. Demographics, sexual behaviour risk, antibiotic use, and blood samples for analysis of N. gonorrhoeae-specific immune responses, will be collected during the study. The primary outcome is the number of N. gonorrhoeae infections in participants over 2 years measured by nucleic acid amplification test (NAAT). Secondary outcomes are vaccine-induced N. gonorrhoeae-specific immune responses, and adverse events in trial participants.
Discussion: This trial will determine if the 4CMenB vaccine is able to reduce N. gonorrhoeae infection. If shown to be effective, 4CMenB could be used in gonococcal prevention. Analysis of 4CMenB-induced immune responses will increase understanding of the type of immune response needed to prevent N. gonorrhoeae, which may enable identification of a potential correlate of protection to aid future gonorrhoea vaccine development.
Trial registration: The trial has been registered on the Australian and New Zealand Clinical Trials Registry (ACTRN12619001478101) on 25 October 2019.
Leigh Syndrome Global Patient Registry: Uniting Patients and Researchers Worldwide
Authors: Zilber Sophia , Woleben Kasey , Johnson Simon , de Souza Carolina Fischinger Moura , Boyce Danielle , Freiert Kevin , Boggs Courtney , Messahel Souad , Burnworth Melinda , Afolabi Titilola , Kayani Saima 
Published: February 2023

Abstract
Background
Leigh Syndrome (LS) is a rare genetic neurometabolic disorder, that leads to the degeneration of the central nervous system and subsequently, early death. LS can be caused by over 80 mutations in mitochondrial or nuclear DNA. Patient registries are important for many reasons, such as studying the natural history of the disease, improving the quality of care, and understanding the healthcare burden. For rare diseases, patient registries are significantly important as patient numbers are small, and funding is limited. Cure Mito Foundation started a global patient registry for LS in September 2021 to identify and learn about the LS patient population, facilitate clinical trial recruitment, and unite international patients and researchers. Priorities were to allow researchers and industry partners to access data at no cost through a clear and transparent process, active patient engagement, and sharing of results back to the community.
Results
Patient registry platform, survey design, data analysis process, and patient recruitment strategies are described. Reported results include demographics, diagnostic information, symptom history, loss of milestones, disease management, healthcare utilization, quality of life, and caregiver burden for 116 participants. Results show a high disease burden, but a relatively short time to diagnosis. Despite the challenges faced by families impacted by Leigh syndrome, participants, in general, are described as having a good quality of life and caregivers are overall resilient, while also reporting a significant amount of stress.
Conclusion
This registry provides a straightforward, no-cost mechanism for data sharing and contacting patients for clinical trials or research participation, which is important given the recruitment challenges for clinical trials for rare diseases. This is the first publication to present results from a global patient registry for Leigh Syndrome, with details on a variety of patient-specific and caregiver outcomes reported for the first time. Additionally, this registry is the first for any mitochondrial disease with nearly 70% of participants residing outside of the United States. Future efforts include continued publication of results and further collaboration with patients, industry partners, and researchers.
Study on the correlation and interaction between urinary metals level and diabetes:A case-control study of community-dwelling elderly
Authors: Wang Rui , He Pei , Duan Siyu , Zhang Zhongyuan , Dai Yuqing , Li Meiyan , Shen Zhuoheng , Li Xiaoyu , Song Yanan , Sun Yiping , Zhang Rui , Sun Jian , Yang Huifang 
Published: February 2023

Abstract
Background
It has been reported that metal exposure is associated with the risk of diabetes, but the results are inconsistent.The relationship between diabetes and a single metal might be attenuated or strengthened due to the complex interactions of metals and the chronic diseases comorbidity (especially in the elderly). However, the evidence of multiple metal exposure effect in participants with diabetes only is limited, particularly in the elderly. The present case-control study of 188 diabetic and 376 healthy participants aimed to evaluate the potential relationships between the concentrations of 9 metals in urine and the risk of diabetes and to access the interactive effects of metals in Chinese community-dwelling elderly.
Methods
The urine levels of 9 metals (cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium, lead) were detected by inductively coupled plasma mass spectrometry (ICP-MS) in 564 adults recruited from Yinchuan Community Health Service Center (Yinchuan, China).Logistic regression and restricted cubic spline (RCS) analysis were used to explore the associations and dose-response relationships of urine metals with diabetes. To analysis of multi-metal exposures and diabetes risk, weighted quantile sum regression Models (WQS) and the Bayesian Kernel Machine Regression (BKMR) model were applied.
Results
The concentrations of cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium and lead were higher in the diabetes group (p < 0.05). In logistic regression analysis, we found that the OR values of urinary cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium, and lead quartiles showed an increasing trend. In the single-metal model, the adjusted ORs(95%CI) in the highest quartiles were 2.94(1.72,5.05) for cobalt,5.05 (2.85,8.93) for zinc, 2.28(1.32,3.91) for copper, 1.99(1.15,3.43) for arsenic, 2.61(1.54,4.43) for molybdenum, 2.89(1.68,4.96) for cadmium, 2.52(1.44,4.41) for tellurium, 3.53(2.03,6.12) for thallium and 2.18(1.27,3.75) for lead compared with the lowest quartile. And in the RCS model, the concentrations of cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium and lead showed a nonlinear dose-response relationship with diabetes risk (P-overall < 0.05,P-nonlinear < 0.05). The results from multi-pollutant models all indicated that metal mixture was positively associated with the risk of diabetes, and Zn and Tl were the major contributors to the combined effect.
Conclusion
Elevated levels of urine cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium and lead were associated with increased risk of diabetes. There is a positive interaction between Zn and Tl on diabetes.
Is Food Insecurity a Predictor of Sustainable and Healthy Eating Behaviors?
Authors: SELÇUK Kevser TARI , Atan Ramazan Mert , ARSLAN Sedat , ŞAHİN Nursel 
Published: February 2023

Abstract
In this cross-sectional study, it was aimed to investigate the relationship between food insecurity and sustainable and healthy eating (SHE) behaviors in adults. The study included 410 adults who were reached through social media applications. Data were collected through an online questionnaire including the Descriptive Information Form, the Household Food Insecurity Access Scale (HFIAS), and the SHE Behaviors Scale. The proportion of participants determined as mildly food insecure, moderately food insecure and severely food insecure was 10.2%, 6.6%, and 7.6%, respectively. Household food insecurity is adversely correlated with the Healthy and Balanced Diet (β:-0.226, p < 0.001), Quality Labels (β:-0.230, p < 0.001), Seasonal Foods and Avoidance of Food Waste (β:-0.261, p < 0.001), Animal Welfare (β:-0.174, p < 0.001) and Fat Intake (β:-0.181, p < 0.001). Household food insecurity is the negative predictor of healthy and balanced diet, Quality Labels, Seasonal Foods and Avoidance of Food Waste, Animal Welfare and Fat Intake.
Creep and strength characteristics of cemented gangue backfill under coupling effect of load and acid corrosion
Authors: Guo Yuxia , Zhao Yonghui , Feng Guorui 
Published: February 2023

Abstract
Cemented gangue backfill technology is beneficial to the reuse of solid waste and sustainable economic development. However, Mine water has a great impact on the strength and deformation of cemented gangue backfill (CGB). In this study, the CGB specimens under load were placed in simulated acid mine water (H2SO4 solution). The changes of deformation, resistivity, and ultrasonic pulse velocity (UPV) of CGB were monitored. On the 360th day, the stress-strain curve and acoustic emission (AE) energy of the specimen during loading were recorded. the degradation mechanism of CGB was discussed by scanning electron microscope (SEM), and X-ray diffraction (XRD). The results showed that: the deformation of CGB increased with time. The effect of H2SO4 solution concentration on the deformation was different in early and late stages. Applying 80% stress-strength ratio (SSR) reduced the strength and increased the deformation. The UPV and resistivity had different characteristics at different corrosion ages, which could be used as long-term stability monitoring of CGB. The CGB showed the strongest AE energy characteristics near the peak stress. The AE energy decreased with the increase of pH value in the pore compaction stage, and the AE activity of the CGB under 80% SSR was much greater than that of the CGB under 40% SSR. The erosion of H2SO4 solution on the CGB was inhibited by applying a small load. Excessive load aggravated the erosion deterioration of CGB due to initial plastic damage. The research results can provide reference for durability design of CGB.
Optical coherence tomographic findings of glaucomatous
eyes with papillomacular retinoschisis
Authors: Ishida Tomoka , Kita Yoshiyuki , Mizuno Masaharu , Hirota Kazunari , Koto Takashi , Inoue Makoto , Hirakata Akito 
Published: February 2023

Abstract
Objectives
To investigate the topographic relationship between the shape of the optic nerve head (ONH) margin detected by optical coherence tomography (OCT) and the clinical characteristics of papillomacular retinoschisis (PMRS) in glaucomatous eyes.
Methods
The medical record of patients with a PMRS in a glaucomatous eye were reviewed. The eyes were placed into two groups determined by the shape of the ONH margin in the OCT images; eyes with an externally oblique ONH margin (Group 1) and the eyes with an internally oblique ONH margin (Group 2). We compared the clinical characteristics of the PMRS between these two groups.
Results
We studied 31 eyes of 29 patients with PMRS and glaucoma with 24 eyes in Group 1 and 7 eyes in Group 2. The optic nerve fiber layer schisis on the lamina cribosa (LC), beta zone, and gamma zone, and the LC defects were detected significantly more frequently in Group 1 than in Group 2 eyes (P < 0.05). A retinal nerve fiber schisis was observed around the ONH significantly more frequently in Group 2 than Group 1 eyes (P < 0.01).
Conclusion
These findings suggest that the PMRS in Group 1 eyes develops most likely around the LC defects while the PMRS in Group 2 eyes develops most likely from the optic nerve fiber layer around the ONH.
Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma
Authors: Yu Yang , Xiang Chan , Zhang Min , Shang Zhanxian , Chen Shengnan , Zhao Jikai , Ding Bowen , Jiang Dong , Zhu Qian , Teng Haohua , Zhu Lei , Shao Jinchen , Zhao Ruiying , Yu Yang 
Published: February 2023

Abstract
The authors have requested that this preprint be removed from Research Square.