bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in Ovarian Cancer Care and Unmet Treatment Needs for Patients With Platinum Resistance
Authors: Richardson Debra L. , Eskander Ramez N. , O’Malley David M. 
Published: April 2023

ImportancePlatinum-based chemotherapy has been the standard of care for ovarian cancer for the past 3 decades. Although most patients respond to platinum-based treatment, emergence of platinum resistance in recurrent ovarian cancer is inevitable during the disease course. Outcomes for patients with platinum-resistant ovarian cancer are poor, and options remain limited, highlighting a substantial unmet need for new treatment options.ObservationsThis review summarizes the current and evolving treatment landscape for platinum-resistant ovarian cancer with a focus on the development of novel compounds. Biologic and targeted therapies such as bevacizumab and poly (ADP-ribose) polymerase (PARP) inhibitors—originally approved in the platinum-resistant setting but since withdrawn—are now used in the up-front or platinum-sensitive setting, prolonging the duration of platinum sensitivity and delaying the use of nonplatinum options. The greater use of maintenance therapy and the emphasis on using platinum beyond first-line treatment has most likely been associated with a greater number of lines of platinum therapy before a patient is designated as having platinum-resistant ovarian cancer. In this contemporary setting, recent trials in platinum-resistant ovarian cancer have mostly had negative outcomes, with none having a clinically significant effect on progression-free or overall survival since the approval of bevacizumab in combination with chemotherapy. Nonetheless, a multitude of new therapies are under evaluation; preliminary results are encouraging. A focus on biomarker-directed treatment and patient selection may provide greater success in identifying novel therapies for treating platinum-resistant ovarian cancer.Conclusions and RelevanceAlthough many clinical trials in platinum-resistant ovarian cancer have had negative outcomes, these failures provide insights into how clinical trial design, biomarker-directed therapy, and patient selection could facilitate future successes in platinum-resistant ovarian cancer treatment.
Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation
Authors: Mo Shaobo , Ye Li , Wang Dongyang , Han Lingyu , Zhou Shuang , Wang Hui , Dai Weixing , Wang Yichao , Luo Wenqin , Wang Renjie , Xu Ye , Cai Sanjun , Liu Rui , Wang Zheng , Cai Guoxiang 
Published: April 2023

ImportanceDetection of molecular residual disease and risk stratification as early as possible may improve the treatment of patients with cancer. Efficient pragmatic tests are therefore required.ObjectiveTo measure circulating tumor DNA (ctDNA) with 6 DNA methylation markers in blood samples and to evaluate the association of the presence of ctDNA with colorectal cancer (CRC) recurrence throughout the disease course.Design, Setting, and ParticipantsIn this multicenter prospective longitudinal cohort study performed from December 12, 2019, to February 28, 2022, 350 patients with stage I to III CRC were recruited from 2 hospitals for collection of blood samples before and after surgery, during and after adjuvant chemotherapy, and every 3 months for up to 2 years. A multiplex, ctDNA methylation, quantitative polymerase chain reaction assay was used to detect ctDNA in plasma samples.ResultsA total of 299 patients with stage I to III CRC were evaluated. Of 296 patients with preoperative samples, 232 (78.4%) tested positive for any of the 6 ctDNA methylation markers. A total of 186 patients (62.2%) were male, and the mean (SD) age was 60.1 (10.3) years. At postoperative month 1, ctDNA-positive patients were 17.5 times more likely to relapse than were ctDNA-negative patients (hazard ratio [HR], 17.5; 95% CI, 8.9-34.4; P &amp;lt; .001). The integration of ctDNA and carcinoembryonic antigen tests showed risk stratification for recurrence with an HR of 19.0 (95% CI, 8.9-40.7; P &amp;lt; .001). Furthermore, ctDNA status at postoperative month 1 was strongly associated with prognosis in patients treated with adjuvant chemotherapy of different durations and intensities. After adjuvant chemotherapy, ctDNA-positive patients had a significantly shorter recurrence-free survival than did the ctDNA-negative patients (HR, 13.8; 95% CI, 5.9-32.1; P &amp;lt; .001). Longitudinal ctDNA analysis after the postdefinitive treatment showed a discriminating effect in that ctDNA-positive patients had poorer recurrence-free survival than did the ctDNA-negative patients (HR, 20.6; 95% CI, 9.5-44.9; P &amp;lt; .001). The discriminating effect was enhanced (HR, 68.8; 95% CI, 18.4-257.7; P &amp;lt; .001) when ctDNA status was maintained longitudinally. Postdefinitive treatment analysis detected CRC recurrence earlier than radiologically confirmed recurrence, with a median lead time of 3.3 months (IQR, 0.5-6.5 months).Conclusions and RelevanceThe findings of this cohort study suggest that longitudinal assessment of ctDNA methylation may enable the early detection of recurrence, potentially optimizing risk stratification and postoperative treatment of patients with CRC.
Autonomous perception method of multi‐degree‐of‐freedom industrial robot arm trajectory
Authors: Qian Xiaochuan 
Published: April 2023

AbstractIn this study, a novel autonomous sensing method of multi‐degree‐of‐freedom industrial robot arm trajectory is proposed. The research takes the distance sensor to collect environmental data, and takes the point cloud data scanned by 3D laser as the basis. The environment model of multi‐degree‐of‐freedom industrial robotic arm is established by Iterative Closest Point (ICP). Then the target object is calibrated by binocular imaging technology. Subsequently, angle of each joint of multi‐degree‐of‐freedom industrial robotic arm is calculated to determine the spatial attitude of the robotic arm. In addition, 3D LiDAR is installed at the end of the robotic arm, and the end trajectory of multi‐degree‐of‐freedom industrial robotic arm is sensed autonomously by using the optimal function. The proposed method has advantages of high accuracy and short sensing time in autonomous sensing of multi‐degree‐of‐freedom industrial robot arm trajectory.
Bidirectional and Dual‐Mode Organic Photodetector Enables Secure Ultraviolet Communication
Authors: Yan Tingting , Li Ziqing , Su Li , Wu Limin , Fang Xiaosheng 
Published: April 2023

AbstractTraditional optical communication mode with single‐band photodetector depicts terrible confidentiality and it depends on sophisticated cryptography schemes to obtain a secure communication process. Dual‐band photodetectors have potential to realize a secure optical communication with a straightforward optical encryption strategy. However, previous reports of dual‐band organic photodetectors (OPD) relied on the multi‐stacked photosensitive layers thus there remain challenges in spectral matching and interfaces contacting. Here, a structurally simple bidirectional and UV–vis dual‐band OPD is proposed, with single photosensitive layer sitting between electrodes. By elaborately regulating the optical field distribution and vertical phase segregation of the bulk heterojunction (BHJ), this OPD presents completely distinct spectral response ranges under bidirectional illuminations. Finally, this OPD outputs outstanding self‐powered UV and vis dual‐band responsivities (up to 30 and 50 mA W−1) as the light illuminates from forward and backward direction, respectively. In addition, a stable and reliable optical communication system is realized based on this OPD where the UV response conveys valid information and further superimposes vis response for encryption. This design concept offers a simple alternative for achieving varied response windows and opens up a novel optical encryption method, which has potential be applied in a close‐range private communication process.
Ultrafast Superfilling Construction of a Metal Artificial Interface for Long‐Term Stable Zinc Anodes
Authors: Jiao Qiyang , Zhai Xingwu , Sun Zhixin , Wang Wenjie , Liu Shihao , Ding Hui , Chu Wangsheng , Zhou Min , Wu Changzheng 
Published: April 2023

AbstractZinc (Zn)‐metal anodes are promising candidates for large‐scale, highly safe energy‐storage systems. However, their cycling life is associated with instability issues such as dendritic growth, corrosion, and hydrogen evolution. Introducing an artificial metal interface is expected to help overcome this challenge owing to the optimization of the absorption, nucleation, and growth of Zn2+. In this study, an ultrafast, universal, and cost‐effective superfilling approach is developed to construct a metal artificial interface decorated Zn anode in situ. Most zincophilic metals, including Sn, Cu, and Ag, can be used to construct a homogenous interface without any restrictions on the size, morphology, or curvature of the substrates. With Sn as a proof‐of‐concept demonstration, the as‐obtained Sn@Zn anode is conducive for the homogenous Zn nuclei and 2D diffusion of Zn2+ ions. Symmetric cells with Sn@Zn electrodes can be operated for over 900 h at different current densities. This superior performance contributes to the attractive electrochemical characteristics of both coin and scaled‐up Sn@Zn//β‐MnO2 cells. Given the facile and cost‐effective fabrication and recyclability of the cells, this work enables the efficient design and exploration of Zn anodes for research, industrialization, and commercialization purposes.
Quasi‐Solid Aqueous Electrolytes for Low‐Cost Sustainable Alkali‐Metal Batteries
Authors: Yi Xianhui , Feng Yanhong , Rao Apparao M. , Zhou Jiang , Wang Chengxin , Lu Bingan 
Published: April 2023

AbstractAqueous electrolytes are highly important for batteries due to their sustainability, greenness, and low cost. However, the free water molecules react violently with alkali metals, rendering the high‐capacity of alkali‐metal anodes unusable. Here, water molecules are confined in a carcerand‐like network to build quasi‐solid aqueous electrolytes (QAEs) with reduced water molecules' freedom and matched with the low‐cost chloride salts. The formed QAEs possess substantially different properties than liquid water molecules, including stable operation with alkali‐metal anodes without gas evolution. Specifically, the alkali‐metal anodes can directly cycle in a water‐based environment with suppressed growth of dendrites, electrode dissolution, and polysulfide shuttle. Li‐metal symmetric cells achieved long‐term cycling over 7000 h (and over 5000/4000 h for Na/K symmetric cells), and all the Cu‐based alkali‐metal cells exhibited a Coulombic efficiency of over 99%. Full metal batteries, such as Li||S batteries, attained high Coulombic efficiency, long life (over 4000 cycles), and unprecedented energy density among water‐based rechargeable batteries.
Real‐Time Quantification of Cell Mechanics and Functions by Double Resonator Piezoelectric Cytometry – Theory and Study of Cellular Adhesion of HUVECs
Authors: Zhou Tiean , Huang Jingyuan , Xiong Lun , Shen Haibo , Huang Fushen , Li Wenwei , Peng Hange , Su Zhaohong , Pan Weison , Zhao Jia , Zhou Zhen , Bao Dongqin , Deng Linhong 
Published: April 2023

AbstractCell mechanics is closely associated with cellular structure and function. However, the inability to measure both cellular force and viscoelasticity of statistically significant number of cells noninvasively remains a challenge for quantitative characterizations of various cellular functions and practical applications. Here a double resonator piezoelectric cytometry (DRPC), using AT and BT cut quartz crystals of the same frequency and surface morphology is developed to simultaneously quantify the cells‐generated forces (ΔS) and viscoelastic moduli (G′, G″) of a population of isolated single cells or cells with different degrees of cell‐cell interactions in a non‐invasive and real time manner. DRPC captures the dynamic mechanical parameters ΔS and G′, G″ during the adhesions of human umbilical vein endothelial cells (HUVECs) under different ligand densities of adhesion molecules fibronectin or Arg‐Gly‐Asp (RGD) modified on the gold surfaces of 9 MHz AT and BT cut quartz crystals, and different seeding densities of HUVECs. It is found that both the ligand density and cell seeding density affect the magnitudes of ΔS and G′, G″ and their correlations are revealed for the first time by DRPC. The validity of DRPC is further verified by mechanical changes of the cells in response to treatments with cytoskeleton regulators.
Color‐Tunable Elastic Photonic Shells With High Color Saturation and Deformability
Authors: Kim Jong Hyun , Hamonangan Wahyu Martumpal , Kim Shin‐Hyun 
Published: April 2023

AbstractPhotonic microspheres containing colloidal arrays are useful as structural colorants in inks and cosmetics. However, low color saturation and low deformability of the microspheres restrict the uses. To overcome the limitations, elastic photonic shells with enhanced color saturation and high deformability using water‐in‐oil‐in‐water (W/O/W) double‐emulsion templates are designed. The elastic shells are produced by photocuring acrylate‐based resin containing non‐close‐packed arrays of silica particles in the middle oil layer. The presence of two concentric interfaces and water‐soluble molecules in the inner and continuous water phases at high concentrations improve the crystalline order of silica particles. In addition, the absence of a relatively disordered core reduces incoherent random scattering, thereby enhancing color saturation. Although the shells themselves are elastically deformable, the liquid core renders them significantly more deformable with small stiffness and negligible hysteresis, which is potentially beneficial for improving the fluidity of suspensions. Moreover, the structural colors of the elastic shells are post‐tunable by osmotic inflation of the semipermeable shells in hypotonic conditions. The high color saturation and high deformability as well as color tunability will provide a new opportunity for structural coloration with the elastic photonic shells as a colorant in inks and cosmetics.
Low‐Temperature Atomic Layer Deposition of Double‐Layer Water Vapor Barrier for High Humidity Stable Perovskite Solar Cells
Authors: Yang Yifan , Zhang Yujing , Li Ran , Mbumba Manala Tabu , Akram Muhammad Waleed , Pan Jiahong , Cai Molang , Dai Songyuan , Guli Mina 
Published: April 2023

AbstractIn recent years, remarkable progress has been made in improving the power conversion efficiency of perovskite solar cells, but their long‐term stability is not so optimistic. In response to this, ion engineering, interface engineering, and encapsulation engineering have been used to enhance the long‐term stability of solar devices. Here, a double‐layer water vapor barrier consisting of SiAlxOy buffer layer and SiO2 vapor isolation layer, prepared by atomic layer deposition under 100 °C, is demonstrated. SiAlxOy layer provides sufficient self‐limiting reactive sites for the deposition of SiO2, so that a more uniform and dense vapor isolation layer can be deposited. This double‐layer water vapor barrier can effectively isolate water vapor to erode the internal functional layers of the perovskite device, prevent ion migration, and improve the long‐term stability of the device. Moreover, the SiAlxOy/SiO2 barrier can be conducive to the transfer of charge between interfaces, and further enhances the conversion efficiency of the device. Overall, compared with the control device, the conversion efficiency of the perovskite device with a double‐layer water vapor barrier is increased from 17.08% to 19.16%, and the long‐term stability is significantly improved, which can maintain 92% efficiency for 2400 h under 35% humidity at room temperature.
3‐Hydroxypyridinyl‐Substituted‐1,2,4‐Triazoles as New ESIPT Based Fluorescent Dyes: Synthesis and Structure–Fluorescence Properties Correlations
Authors: Nina‐Diogo Anthony , Bertrand Benoît , Thorimbert Serge , Gontard Geoffrey , Nassem‐Kahn Sehr , Echeverri Andrea , Contreras‐García Julia , Allain Clémence , Lemercier Gilles , Luppi Eleonora , Botuha Candice 
Published: April 2023

AbstractThis report presents the design, synthesis, and photophysical study of two new series of promising fluorescent trisubstituted triazoles, 3‐hydroxypyridinyl substituted‐1,2,4‐triazoles (PyOHTr) and 2‐pyridonyl substituted‐1,2,4‐triazoles (PyCOTr). An excited state intramolecular proton transfer (ESIPT) fluorescence mechanism is evidenced for PyOHTr molecules by ab initio theoretical calculations. These fluorescent dyes possess unique optical properties such as large Stokes shifts, dual emission, solvatochromism, solid‐state emission and, for one of them, a white light emission, rendering them particularly attractive for future applications in both medicinal chemistry and materials science.
A Functionalized Metal–Organic Framework‐Based Controlled Dual‐Drug Delivery System with Short Hairpin RNA and Simvastatin for Ferroptosis in Colorectal Cancer
Authors: Liu Haixia , Yao Xianxian , Zhu Weichu , Zhang Jiaxin , Ma Shuangping , Lu Daru , Yang Wuli 
Published: April 2023

AbstractColorectal cancer is one of the most common causes of cancer‐related deaths worldwide. Ferroptosis is a non‐apoptotic form of regulated cell death that can be triggered by excessive lipid peroxidation and provides an alternative cancer treatment option. To design ferroptosis‐targeted nanomedicine, a new type of nanoparticle is synthesized. The antineoplastic agent simvastatin (SIM) and specifically designed short hairpin RNA (shRNA) are co‐loaded into zeolitic imidazolate framework‐8 (ZIF‐8) nanoparticles coated with poly(carboxybetaine methacrylate) (PCBMA). The constructed shRNA/ZIF‐8@PCBMA‐SIM nanoparticles effectively eliminate human colorectal carcinoma cells in vivo, showing superior cytotoxicity against tumors owing to their improved targeting ability and the high retention of antineoplastic agents delivered at tumor sites. Furthermore, SIM and shRNA downregulate the expression of ferroptosis‐related enzymes 3‐hydroxy‐3‐methylglutaryl‐CoA reductase and glutathione peroxidase 4, thus, triggering ferroptosis in cancer cells. Given that SIM is already approved for clinical use, and shRNA offers high potency to downregulate the cystine/glutamate antiporter (x‐CT) system protein (subunit SLC7A11), shRNA/ZIF‐8@PCBMA‐SIM nanoparticles show great clinical potential to treat colorectal cancer via ferroptosis. This presents an alternative therapy that addresses the limitations of chemotherapy.
A Mixed Protonic–Electronic Conductor Base on the Host–Guest Architecture of 2D Metal–Organic Layers and Inorganic Layers
Authors: He Xing‐Lu , Shao Bing , Huang Rui‐Kang , Dong Min , Tong Yu‐Qing , Luo Yan , Meng Ting , Yang Fu‐Jie , Zhang Zhong , Huang Jin 
Published: April 2023

AbstractThe key to designing and fabricating highly efficient mixed protonic–electronic conductors materials (MPECs) is to integrate the mixed conductive active sites into a single structure, to break through the shortcomings of traditional physical blending. Herein, based on the host–guest interaction, an MPEC is consisted of 2D metal–organic layers and hydrogen‐bonded inorganic layers by the assembly methods of layered intercalation. Noticeably, the 2D intercalated materials (≈1.3 nm) exhibit the proton conductivity and electron conductivity, which are 2.02 × 10−5 and 3.84 × 10−4 S cm−1 at 100 °C and 99% relative humidity, much higher than these of pure 2D metal–organic layers (>>1.0 × 10−10 and 2.01×10−8 S cm−1), respectively. Furthermore, combining accurate structural information and theoretical calculations reveals that the inserted hydrogen‐bonded inorganic layers provide the proton source and a networks of hydrogen−bonds leading to efficient proton transport, meanwhile reducing the bandgap of hybrid architecture and increasing the band electron delocalization of the metal–organic layer to greatly elevate the electron transport of intrinsic 2D metal–organic frameworks.
BiTE‐Secreting CAR‐γδT as a Dual Targeting Strategy for the Treatment of Solid Tumors
Authors: Huang Shi‐Wei , Pan Chih‐Ming , Lin Yu‐Chuan , Chen Mei‐Chih , Chen Yeh , Jan Chia‐Ing , Wu Chung‐Chun , Lin Fang‐Yu , Wang Sin‐Ting , Lin Chen‐Yu , Lin Pei‐Ying , Huang Wei‐Hsaing , Chiang Yu‐Ting , Tsai Wan‐Chen , Chiu Ya‐Hsu , Lin Ting‐Hsun , Chiu Shao‐Chih , Cho Der‐Yang 
Published: April 2023

AbstractHLA‐G is considered as an immune checkpoint protein and a tumor‐associated antigen. In the previous work, it is reported that CAR‐NK targeting of HLA‐G can be used to treat certain solid tumors. However, the frequent co‐expression of PD‐L1 and HLA‐G) and up‐regulation of PD‐L1 after adoptive immunotherapy may decrease the effectiveness of HLA‐G‐CAR. Therefore, simultaneous targeting of HLA‐G and PD‐L1 by multi‐specific CAR could represent an appropriate solution. Furthermore, gamma‐delta T (γδT) cells exhibit MHC‐independent cytotoxicity against tumor cells and possess allogeneic potential. The utilization of nanobodies offers flexibility for CAR engineering and the ability to recognize novel epitopes. In this study, Vδ2 γδT cells are used as effector cells and electroporated with an mRNA‐driven, nanobody‐based HLA‐G‐CAR with a secreted PD‐L1/CD3ε Bispecific T‐cell engager (BiTE) construct (Nb‐CAR.BiTE). Both in vivo and in vitro experiments reveal that the Nb‐CAR.BiTE‐γδT cells could effectively eliminate PD‐L1 and/or HLA‐G‐positive solid tumors. The secreted PD‐L1/CD3ε Nb‐BiTE can not only redirect Nb‐CAR‐γδT but also recruit un‐transduced bystander T cells against tumor cells expressing PD‐L1, thereby enhancing the activity of Nb‐CAR‐γδT therapy. Furthermore, evidence is provided that Nb‐CAR.BiTE redirectes γδT into tumor‐implanted tissues and that the secreted Nb‐BiTE is restricted to the tumor site without apparent toxicity.
Multi‐Dimensional Mechanical Mapping Sensor Based on Flexoelectric‐Like and Optical Signals
Authors: Zhang Peng , Teng Zhaowei , Zhao Lei , Liu Zhichao , Yu Xue , Zhu Xiaodie , Peng Songcheng , Wang Ting , Qiu Jianbei , Wang Qingyuan , Xu Xuhui 
Published: April 2023

AbstractMechanical sensors execute multi‐mode response to external force, which are cornerstones for applications in human–machine interactions and smart wearable equipments. Nevertheless, an integrated sensor responding to mechanical stimulation variables and providing the information of the corresponding signals, as velocity, direction, and stress distribution, remains a challenge. Herein, a Nafion@Ag@ZnS/polydimethylsiloxanes (PDMS) composite sensor is explored, which realizes the description of mechanical action via optics and electronics signals simultaneously. Combined with the mechano‐luminescence (ML) originated from ZnS/PDMS and the flexoelectric‐like effect of Nafion@Ag, the corresponding explored sensor achieves the detection of magnitude, direction, velocity, mode of mechanical stimulation, and the visualization of the stress distribution. Moreover, the outstanding cyclic stability, linearity response character, and rapid response time are demonstrated. Accordingly, the intelligent recognition and manipulation of a target are realized, which indicate a smarter human–machine interface sensing applied for wearable devices and mechanical arms can be expected.