bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation Y’s behavioural usage of small businesses’ retail websites: gender difference
Authors: Lim Allen , Goi Chai Lee , Dell Peter , Goi Mei Teh 
Published: June 2023

Purpose
To better understand continuities and changes in consumer behaviour, it is also important to examine the original antecedents of unified theory of acceptance and use of technology 2 (UTAUT2). Studying Generation Y is crucial for developing competitive online marketing strategies, as Generation Y plays a substantial role in online purchases. Therefore, this study aims to examine the actual use of small business websites based on the UTAUT2 among Generation Y.

Design/methodology/approach
A total of 375 valid questionnaires were collected via a systematic sampling among Generation Y in Canada. All participants in the study had at least a high school education, were internet and computer literate, and had purchased a good/service from the retail websites of Canadian small businesses.

Findings
The results show performance expectancy, hedonic motivation, social influence and habit have significant effects on behavioural intentions. The habit and behavioural intentions also have significant effects on actual usage of small businesses’ retail websites. Additionally, this study supported the significant difference between male and female UTAUT2 models.

Practical implications
The study examines how small retail businesses can attract and retain Generation Y customers by improving their website’s performance. Performance expectancy, hedonic motivation and social influence are significant factors in determining behavioral intention. Small businesses can enhance their website usability, design and content to increase customer satisfaction and loyalty. Hedonic motivation is crucial for Generation Y customers, who seek pleasure and excitement when visiting websites. Social influence is crucial for male customers, whereas performance expectancy, hedonic motivation and habit are more important for female customers. The study also suggests that Canadian governments should encourage online purchasing to increase the usage of small retail business websites.

Originality/value
This study provided few valuable insights into small businesses’ retail websites behavioural intentions and actual usage between males and females in Canada.
Determinants of patients' service choice in online health communities: an elaboration likelihood model perspective
Authors: Chen Yuangao , Liu Meng , Chen Mingjing , Wang Lu , Sun Le , Xuan Gang 
Published: June 2023

PurposeThe purpose of this research paper is to explore the determinants of patients' service choices between telephone consultation and text consultation in online health communities (OHCs).Design/methodology/approachThis study utilized an empirical model based on the elaboration likelihood model and examined the effect of information, regarding service quality (the central route) and service price (the peripheral route), using online health consultation data from one of the largest OHCs in China.FindingsThe logistic regression results indicated that both physician- and patient-generated information can influence the patients' service choices; service price signals will lead patients to cheaper options. However, individual motivations, disease risk and consulting experience change a patients' information processing regarding central and peripheral cues.Originality/valuePrevious researchers have investigated the mechanism of patient behavior in OHCs; however, the researchers have not focused on the patients' choices regarding the multiple health services provided in OHCs. The findings of this study have theoretical and practical implications for future researchers, OHC designers and physicians.
Climate change and food security at household level in the central dry zone in Myanmar
Authors: Zaw Aung Kyaw , Charoenratana Sayamol 
Published: June 2023

PurposeThe central dry zone of Myanmar is a climatic risk area in which the inhabitants are experiencing food insecurity, demonstrating the link between water scarcity and climate risk in agricultural production. Households in the region face the challenge of developing adaptation strategies to cope with the impact of climate change on food security. This study aims to seek an effective climate change solution and analyse its impact on Myanmar's food security and household adaptation.Design/methodology/approachThe authors draw on insights from mixed-method research using a qualitative method followed by quantitative methods. In the qualitative phase, the authors used purposive sampling with two focus group discussions and three stakeholder interviews. In the quantitative phase, data were collected from 102 face-to-face interviews with members of households selected from Pauk Township, Pakokku District, Magway Region, Myanmar. The household food insecurity access scale (HFIAS) was used in the analysis.FindingsThe HFIAS indicated that 13% of households have adapted to climate change. The study illustrates that climate change adaptation strategies in production activities are related to food insecurity. The results further demonstrated the effect of climate change on crops, which impacts debt, access to food, selling assets and urban migration. The findings also suggest that climate change adaptation to improve food security has played an important role in providing outside support, which leads to household food insecurity.Originality/valueTo the authors' best knowledge, the study is one of the first to use mixed-method research to investigate climate change, food security and household adaptation in the central dry zone of Myanmar.
Exploring the nexus of social support, work–life balance and life satisfaction in hybrid work scenario in learning organizations
Authors: Mishra Nidhi , Bharti Teena 
Published: June 2023

Purpose
The purpose of this paper is to examine the nexus of social support (SS), work–life balance (WLB) and satisfaction with life (SWL) in hybrid work (HW) scenario in learning organizations.

Design/methodology/approach
The data were collected via questionnaire method from 531 employees working in learning organizations (IT/ITES sector) in India. The hypotheses were tested using hierarchical regression.

Findings
The findings of the study showed that HW was positively related to SS dimensions, WLB and SWL. Further, the study established the mediating role of SS between HW and WLB as well as WLB as a mediator between HW-SWL relationships.

Research limitations/implications
This study has certain limitations owing to the cross-sectional nature of the data and the specific sector under study. The findings have significant implications for policy making to determine the conditions under which both employees and organizations can benefit from HW. Further, the study has implications for uncertain and volatile environments as had been created by COVID-19 pandemic, where HW arrangements may not be a choice but become necessity.

Originality/value
This study contributes to the conservation of resources theory. It identifies the importance of true autonomy and flexibility for employees.
Cyanobacteria as a critical reservoir of the environmental antimicrobial resistome
Authors: Timms V. J. , Hassan K. A. , Pearson L. A. , Neilan B. A. 
Published: June 2023

AbstractAntimicrobial resistance (AMR) is predicted to cause a worldwide annual toll of 10 million deaths by 2050. This looming public health threat has been linked to antibiotic overuse and pollution, which places selective pressures on AMR maintenance and transfer in and between microbial populations. We examined the distribution, diversity and potential mobility of AMR genes in cyanobacteria. While cyanobacteria are not pathogenic, we hypothesised that they could be a major environmental reservoir for AMR genes. Genes encoding AMR to seven antimicrobial drug classes were found in 10% of cyanobacterial genomes. AMR genes were found in 13% of freshwater, 19% of terrestrial, 34% of symbiotic, 2% of thermal spring, and 3% of marine genomes. AMR genes were found in five cyanobacterial orders with 23% of Nostocales and 8% of Oscillatoriales strains containing AMR genes. The most frequently observed alleles were ansamycin resistance genes, which were present in 7% of strains. AMR genes responsible for resistance to broad‐spectrum β‐lactams, chloramphenicols, tetracyclines, macrolides, and aminoglycosides were associated with mobile genetic elements or plasmid replicons or both. These results suggest that cyanobacteria are an extensive reservoir, and potential vector, for AMR genes in diverse terrestrial and aquatic habitats.
Enhancing the efficacy of instructing and adjusting information: An exploration of interactivity and vividness
Authors: Zhou Ziyuan , Zhang Xueying , Ki Eyun‐Jung 
Published: June 2023

AbstractInstructing and adjusting information is required to protect stakeholders during a crisis. However, it is unwise to assume that people, especially young adults, automatically follow the information once it is provided. Using a 2 (interactivity: low [email] vs. high [mobile app]) × 2 (vividness: low [text‐only] vs. high [infographic]) between‐subject lab experiment, this study found that infographics were effective in improving self‐efficacy, proxy efficacy, and trust in the organization. In addition, an interaction was observed between interactivity and vividness on participants' intention to follow instructing and adjusting information. The findings of this study provide evidence of the advantage of using infographics during a crisis.
Climate elasticity assessment on groundwater recharge to the Edwards Balcones Fault Zone Aquifer, United States
Authors: Yang Changbing , Bertetti F. Paul 
Published: June 2023

AbstractThis study presents a comprehensive analysis of the characteristics of precipitation, temperature, and groundwater recharge in the recharge zone of the nine basins of the San Antonio segment of the Edwards Balcones Fault Zone Aquifer, which is one of the major groundwater systems in the United States and serves as primary water sources for approximately 1.7 million people in south‐central Texas. Datasets of monthly precipitation and average temperature (1895–2019) and groundwater recharge (1934–2019) are used to examine the decadal variability in precipitation, temperature, and groundwater recharge on the annual scale with a normalized 20‐year moving average of variance. Climate elasticity (precipitation and potential evapotranspiration) of groundwater recharge is estimated to evaluate impacts of climate change on groundwater recharge. The results of this study show that precipitation and temperature variability exhibit decadal cyclic patterns. Elasticity analysis of groundwater recharge indicates that a 1% change in annual precipitation may result in 2%, with a likely range of 0.15%–2.8%, change in groundwater recharge, and a 1% change in annual potential evapotranspiration may lead to −3.3% change in groundwater recharge with a likely range of −8.9% to 4% in the study area. This study suggests that climate elasticity of groundwater recharge may provide an alternative means for evaluating climate impacts on groundwater recharge to an aquifer.
Efficacy of lazertinib for symptomatic or asymptomatic brain metastases in treatment‐naive patients with advanced EGFR mutation‐positive non‐small cell lung cancer: Protocol of an open‐label, single‐arm phase II trial
Authors: Lee Bora , Ji Wonjun , Lee Jae Cheol , Song Si Yeol , Shin Young Seob , Cho Young Hyun , Park Ji Eun , Park Hyungjun , Choi Chang‐Min 
Published: June 2023

AbstractIntroductionNon‐small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation has a higher incidence of brain metastases than wild‐type EGFR mutations. Osimertinib, a third‐generation EGFR tyrosine kinase inhibitor (TKI), targets both EGFR‐TKI sensitizing and T790M‐resistance mutations and has a higher brain penetration rate relative to first‐ and second‐generation EGFR‐TKIs. Therefore, osimertinib has become a preferred first‐line therapy for advanced EGFR mutation‐positive NSCLC. However, lazertinib, an emerging EGFR‐TKI, has shown higher selectivity toward EGFR mutations and improved penetration of the blood–brain barrier compared to osimertinib in preclinical studies. This trial will evaluate the efficacy of lazertinib as a first‐line therapy in patients with EGFR mutation‐positive NSCLC who have brain metastases, with or without additional local therapy.MethodsThis is a single‐center, open‐label, single‐arm phase II trial. A total of 75 patients with advanced EGFR mutation‐positive NSCLC will be recruited. Eligible patients will receive oral lazertinib 240 mg, once daily until disease progression or intolerable toxicity is detected. Patients with moderate to severe symptoms related to brain metastasis will simultaneously receive local therapy for the brain. The primary endpoints are progression‐free survival and intracranial progression‐free survival.DiscussionLazertinib, in combination with local therapy for the brain, if necessary, is expected to improve the clinical benefit in advanced EGFR mutation‐positive NSCLC with brain metastases, as a first‐line treatment.
Pyrroloquinoline quinone alleviates natural aging‐related osteoporosis via a novel MCM3‐Keap1‐Nrf2 axis‐mediated stress response and Fbn1 upregulation
Authors: Li Jie , Zhang Jing , Xue Qi , Liu Boyang , Qin Ran , Li Yiping , Qiu Yue , Wang Rong , Goltzman David , Miao Dengshun , Yang Renlei 
Published: June 2023

AbstractAge‐related osteoporosis is associated with increased oxidative stress and cellular senescence. Pyrroloquinoline quinone (PQQ) is a water‐soluble vitamin‐like compound that has strong antioxidant capacity; however, the effect and underlying mechanism of PQQ on aging‐related osteoporosis remain unclear. The purpose of this study was to investigate whether dietary PQQ supplementation can prevent osteoporosis caused by natural aging, and the potential mechanism underlying PQQ antioxidant activity. Here, we found that when 6‐month‐old or 12‐month‐old wild‐type mice were supplemented with PQQ for 12 months or 6 months, respectively, PQQ could prevent age‐related osteoporosis in mice by inhibiting osteoclastic bone resorption and stimulating osteoblastic bone formation. Mechanistically, pharmmapper screening and molecular docking studies revealed that PQQ appears to bind to MCM3 and reduces its ubiquitination‐mediated degradation; stabilized MCM3 then competes with Nrf2 for binding to Keap1, thus activating Nrf2‐antioxidant response element (ARE) signaling. PQQ‐induced Nrf2 activation inhibited bone resorption through increasing stress response capacity and transcriptionally upregulating fibrillin‐1 (Fbn1), thus reducing Rankl production in osteoblast‐lineage cells and decreasing osteoclast activation; as well, bone formation was stimulated by inhibiting osteoblastic DNA damage and osteocyte senescence. Furthermore, Nrf2 knockout significantly blunted the inhibitory effects of PQQ on oxidative stress, on increased osteoclast activity and on the development of aging‐related osteoporosis. This study reveals the underlying mechanism of PQQ's strong antioxidant capacity and provides evidence for PQQ as a potential agent for clinical prevention and treatment of natural aging‐induced osteoporosis.
Early response of herbaceous vegetation toRhododendron ponticumsubsp.baeticuminvasion in European Atlantic forests
Authors: Casati Marion , Spicher Fabien , Kichey Thomas , Decocq Guillaume 
Published: June 2023

AbstractQuestionsRhododendron ponticumsubsp.baeticumis an invasive shrub of growing concern in continental Europe, but little is known about its impact on native plant communities. Here we ask: do environmental conditions differ between forest stands invaded by it and uninvaded stands? Do these differences correlate withR. ponticum's cover? Are these differences associated with differences in taxonomic and functional diversity of vascular plant species of the herb layer? Can these vegetation changes be explained by the sorting of certain life‐history traits byR. ponticum‐induced environmental changes?LocationSeveral forests invaded byR. ponticumin the French Atlantic domain.MethodsWe recorded vegetation composition and a number of environmental variables in 400‐m2plots that were established in 64 paired forest stands (32 invaded vs 32 uninvaded). We compiled traits from existing databases. We computed several metrics of taxonomic and functional diversity. We compared environmental variables and diversity metrics between invaded and uninvaded stands. We used correlation and regression analyses to relate them withR. ponticum's cover. We ran RLQ and fourth‐corner analyses to explore the relationships betweenR. ponticuminvasion, environmental variables, species traits, and vegetation composition.ResultsIndependent of its abundance,R. ponticuminvasion was associated with lower light arrival at the forest floor and increased litter thickness. Concomitantly, species richness and diversity and trait diversity were reduced. The major driver of species assemblages was soil pH, which strongly interacted with the invasion gradient.R. ponticumdid not sort species according to traits associated with shade tolerance and thick‐litter tolerance. However, tree and shrub saplings were more abundant in invaded than uninvaded stands, at the expense of graminoid and fern species.ConclusionsAsR. ponticumbecomes the dominant shrub, it exerts new selection forces on life‐history traits of extant species, mostly via reduced light availability, increased litter thickness, and physical competition, thereby reducing taxonomic and functional diversity of the herb layer, without impeding tree and shrub self‐regeneration, at least in the short term.
Transformative medical ethics: A framework for changing practice according to normative–ethical requirements
Authors: Kuehlmeyer Katja , Jansky Bianca , Mertz Marcel , Marckmann Georg 
Published: June 2023

AbstractWe propose a step‐by‐step methodological framework of translational bioethics that aims at changing medical practice according to normative–ethical requirements, which we will thus call “transformative medical ethics.” The framework becomes especially important when there is a gap between widely acknowledged, ethically justified normative claims and their realization in the practice of biomedicine and technology (ought–is gap). Building on prior work on translational bioethics, the framework maps a process with six different phases and 12 distinct translational steps. The steps involve various research activities including conceptual philosophical inquiry and (socio‐)empirical research. On the one hand, the framework can be used as a heuristic tool to identify barriers to the transformation process. On the other hand, it can provide guidance for researchers and practitioners to develop appropriate (conceptual action and practice) models, which are then implemented and evaluated in specific practice contexts. We use the example of realizing the norm of respect for autonomy in the practice of medical decision‐making to illustrate the framework. Further research is required, for example, to theoretically underpin the framework, to apply it to other ought–is gaps, and to evaluate its feasibility and effectiveness in various practice areas. Overall, the framework of transformative medical ethics suggests a strategic process to investigate and promote practice change that is ethically informed in all phases.
Outcomes of haploidentical haematopoietic stem cell transplantation for adolescent and young adults with acute myeloid leukaemia
Authors: Huo Wen‐Xuan , Wen Qi , Zhang Xiao‐Hui , Xu Lan‐Ping , Wang Yu , Yan Chen‐Hua , Chen Huan , Chen Yu‐Hong , Han Wei , Wang Feng‐Rong , Wang Jing‐Zhi , Huang Xiao‐Jun , Mo Xiao‐Dong 
Published: June 2023

SummaryWe aimed to identify the efficacy of haploidentical related donor (HID) haematopoietic stem cell transplantation (HSCT) in adolescent and young adults (AYAs) with acute myeloid leukaemia (AML) in a large cohort. Consecutive AML AYAs (15–39 years old, n = 599) receiving HID HSCT in complete remission (CR) were included. The 3‐year cumulative incidence of measurable residual disease occurrence, relapse and non‐relapse mortality after HID HSCT was 28.6% (95% CI: 25.0–32.2), 11.6% (95% CI: 9.0–14.2) and 6.7% (95% CI: 4.7–8.7) respectively. The 3‐year probability of event‐free survival, leukaemia‐free survival (LFS) and overall survival (OS) after HID HSCT was 60.7% (95% CI: 56.9–64.8), 81.7% (95% CI: 78.7–84.9) and 85.6% (95% CI: 82.8–88.4) respectively. In multivariable analysis, AML risk category at diagnosis and comorbidity burdens before HID HSCT were independently associated with LFS and OS. Compared to the older adults (≥ 40 years, n = 355) with AML receiving HID HSCT in CR during the same time period, AYAs have a lower incidence of non‐relapse mortality and higher probabilities of LFS and OS. Thus, we firstly confirmed the safety and efficacy of HID HSCT in AYAs with AML‐CR.
Labels and descriptions of dental behaviour support techniques: A scoping review of clinical practice guidelines
Authors: Mac Giolla Phadraig Caoimhin , Kammer Pedro Vitali , Asimakopoulou Koula , Healy Olive , Fleischmann Isabel , Buchanan Heather , Newton Jonathon Tim , Daly Blánaid , Posse Jacobo Limeres , Hosey Marie Therese , Yarascavitch Carilynne , MacAuley Yvonne , Stirling Chris , Ahmad Fisal Aisyah Binti , Nunn June 
Published: June 2023

AbstractIntroductionThere is no agreed taxonomy of the techniques used to support patients to receive professional oral healthcare. This lack of specification leads to imprecision in describing, understanding, teaching and implementing behaviour support techniques in dentistry (DBS).MethodsThis review aims to identify the labels and associated descriptors used by practitioners to describe DBS techniques, as a first step in developing a shared terminology for DBS techniques. Following registration of a protocol, a scoping review limited to Clinical Practice Guidelines only was undertaken to identify the labels and descriptors used to refer to DBS techniques.ResultsFrom 5317 screened records, 30 were included, generating a list of 51 distinct DBS techniques. General anaesthesia was the most commonly reported DBS (n = 21). This review also explores what term is given to DBS techniques as a group (Behaviour management was most commonly used (n = 8)) and how these techniques were categorized (mainly distinguishing between pharmacological and non‐pharmacological).ConclusionsThis is the first attempt to generate a list of techniques that can be selected for patients and marks an initial step in future efforts at agreeing and categorizing these techniques into an accepted taxonomy, with all the benefits this brings to research, education, practice and patients.
Mini‐VLAT: A Short and Effective Measure of Visualization Literacy
Authors: Pandey Saugat , Ottley Alvitta 
Published: June 2023

AbstractThe visualization community regards visualization literacy as a necessary skill. Yet, despite the recent increase in research into visualization literacy by the education and visualization communities, we lack practical and time‐effective instruments for the widespread measurements of people's comprehension and interpretation of visual designs. We present Mini‐VLAT, a brief but practical visualization literacy test. The Mini‐VLAT is a 12‐item short form of the 53‐item Visualization Literacy Assessment Test (VLAT). The Mini‐VLAT is reliable (coefficient omega = 0.72) and strongly correlates with the VLAT. Five visualization experts validated the Mini‐VLAT items, yielding an average content validity ratio (CVR) of 0.6. We further validate Mini‐VLAT by demonstrating a strong positive correlation between study participants' Mini‐VLAT scores and their aptitude for learning an unfamiliar visualization using a Parallel Coordinate Plot test. Overall, the Mini‐VLAT items showed a similar pattern of validity and reliability as the 53‐item VLAT. The results show that Mini‐VLAT is a psychometrically sound and practical short measure of visualization literacy.