bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness of HPV-Related Cancers among University Students: A Cross-sectional Study
Authors: Ferreira Chrystiano de Campos , Ferreira Herika Rangel , Leite Jandra Cibele Rodrigues de Abrantes Pereira , Gadelha Gabrielle , Vieira Layssa Gonçalves , Rodrigues Tiago da Cruz , Corrêa Marcelo Regis Lima 
Published: April 2023

Background: HPV is associated with some malignant neoplasms, especially cancers of the cervix, oropharynx, penis, anus and vulva.
Aims: The aim of this study was to analyze the awareness of Human Papillomavirus-associated cancers among university students.
Methodology: We conducted a cross-sectional research among medical students and student nurses from four institutions from June to December 2020. A questionnaire was utilized to obtain information about sexual behavior and awareness of HPV among those students.
Results: A total of 201 undergraduates participated in the study. Of those 147 were medical students and 54 were student nurses. The majority were female 133 (66.17%), and the most frequent age group was 20-24 years old, amounting to 121 (60.20%) students. All participants knew that HPV causes cervical cancer. A little over half of the participants 107 (53.23%) knew the relation between HPV and penile cancer. Less than half 95 (47.26%) knew that HPV causes oropharyngeal cancer. However, only 10 (4.98%) knew that HPV causes anal cancer.
Conclusion: In this study, medical and student nurses showed good awareness of the link between HPV and cervical cancer but limited knowledge of the causal link between HPV and oropharyngeal, penile and anal cancers.
Risk of New Retinal Vascular Occlusion After mRNA COVID-19 Vaccination Within Aggregated Electronic Health Record Data
Authors: Dorney Ian , Shaia Jacqueline , Kaelber David C. , Talcott Katherine E. , Singh Rishi P. 
Published: April 2023

ImportanceNew-onset retinal vascular occlusion (RVO) occurring acutely after messenger RNA (mRNA) COVID-19 vaccination has been described in recent literature. Because RVO can cause vision loss or blindness, an epidemiologic investigation evaluating this potential association is of great importance to public health.ObjectiveTo investigate how often patients are diagnosed with new RVO acutely after the mRNA COVID-19 vaccine compared with influenza and tetanus, diphtheria, pertussis (Tdap) vaccines.Design, Setting, and ParticipantsA retrospective population-based cohort design using the TriNetX Analytics platform, a federated, aggregated electronic health record (EHR) research network containing the deidentified EHR data of more than 103 million patients, was used to examine aggregate EHR data. Data were collected and analyzed on October 20, 2022. Data on patients within the TriNetX Analytics platform were searched for the presence of vaccination Common Procedural Technology codes, and instances of newly diagnosed RVO within 21 days of vaccination were recorded and reported. Propensity score matching based on demographic characteristics (age, sex, race and ethnicity) and comorbidities (diabetes, hypertension, and hyperlipidemia) was performed between vaccination groups for evaluation of relative risks (RRs).Main Outcomes and MeasuresThe appearance of a new-encounter diagnosis of RVO within 21 days of the mRNA COVID-19 vaccination was the primary outcome. Historical comparison cohorts of patients receiving influenza and Tdap vaccinations allowed for evaluation of the RRs for RVO.ResultsOf 3 108 829 patients (mean [SD] age at vaccination, 50.7 [20.4] years; 56.4% women) who received the mRNA COVID-19 vaccine, 104 (0.003%; 95% CI, 0.003%-0.004%) patients had a new diagnosis of RVO within 21 days of vaccination. After propensity score matching, the RR for new RVO diagnosis after the first dose of COVID-19 vaccination was not significantly different from that after influenza (RR, 0.74; 95% CI, 0.54-1.01) or Tdap (RR, 0.78; 95% CI, 0.44-1.38) vaccinations, but was greater when compared with the second dose of the COVID-19 vaccination (RR, 2.25; 95% CI, 1.33-3.81).Conclusions and RelevanceThe findings of this study suggest that RVO diagnosed acutely after mRNA COVID-19 vaccination occurs extremely rarely at rates similar to those of 2 different historically used vaccinations, the influenza and Tdap vaccines. No evidence suggesting an association between the mRNA COVID-19 vaccination and newly diagnosed RVO was found.
MPLA case: How do you lead as a lead physicist?
Authors: Sansourekidou Patricia , Kim Leonard , Xu Lee , Gronberg Mary , Stambaugh Cassandra , Wang Dongxu 
Published: April 2023

AbstractThis work of fiction is part of a case study series developed by the Medical Physics Leadership Academy (MPLA). It is intended to facilitate the discussion of the managerial and leadership challenges faced by a clinical medical physicist. In this case, a physicist David used to work in a clinic where he thrived and felt like a leader, despite not having the title. After a job change, he is now officially the “Lead Physicist” at a hospital newly affiliated with a large academic healthcare system. He believes he will be equally successful. Yet he struggles to bring about changes and get buy‐in from coworkers. In the end, he feels like giving up and considers changing his job. This case is in the scenario of Problem Diagnosis.i The intended use of this case, through group discussion or self‐study, is to encourage readers to perform a comprehensive analysis that identifies the root cause of the problem. This case study falls under the scope of and is supported by the MPLA, a committee in the American Association of Physicists in Medicine (AAPM).
In Situ STING‐Activating Nanovaccination with TIGIT Blockade for Enhanced Immunotherapy of Anti‐PD‐1‐Resistant Tumors
Authors: Zhang Beibei , Zhang Juan , Li Yaqiong , Li Na , Wang Yuzhou , Jang Ru , Xu Xiaoxia , Li Ruifang , Chen Zhenzhen , Duan Shaobo , Wang Yongchao , Zhang Lianzhong 
Published: April 2023

AbstractImmunotherapies comprising programmed cell death protein 1/PD ligand 1 (PD‐1/PD‐L1) immune checkpoint inhibitors are effective cancer treatments. However, the low response rate and immunoresistance resulting from alternative immune checkpoint upregulation and inefficient immune stimulation by T cells are problematic. The present report describes a biomimetic nanoplatform that simultaneously blocks the alternative T‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT) checkpoint and activates the stimulator of interferon genes (STING) signaling pathway in situ for enhanced antitumor immunity. The nanoplatform is engineered by fusing a red blood cell membrane with glutathione‐responsive liposome‐encapsulated cascade‐activating chemoagents (β‐lapachone and tirapazamine), and anchoring them with a detachable TIGIT block peptide (named as RTLT). In the tumor environment, the peptide is spatiotemporally released to reverse T‐cell exhaustion and restore antitumor immunity. The cascade activation of chemotherapeutic agents causes DNA damage and inhibits the repair of double‐stranded DNA, which induces robust in situ STING activation for an efficient immune response. The RTLT inhibits anti‐PD‐1‐resistant tumor growth, and prevents tumor metastasis and recurrence in vivo by inducing antigen‐specific immune memory. This biomimetic nanoplatform thus provides a promising strategy for in situ cancer vaccination.
Design of Fluoro‐Free Surfaces Super‐Repellent to Low‐Surface‐Tension Liquids
Authors: Wong William S. Y. , Kiseleva Mariia S. , Zhou Shaochen , Junaid Muhammad , Pitkänen Leena , Ras Robin H. A. 
Published: April 2023

AbstractSuper‐liquid‐repellent surfaces feature high liquid contact angles and low sliding angles find key applications in anti‐fouling and self‐cleaning. While repellency for water is easily achieved with hydrocarbon functionalities, repellency for many low‐surface‐tension liquids (down to 30 mN m−1) still requires perfluoroalkyls (a persistent environmental pollutant and bioaccumulation hazard). Here, the scalable room‐temperature synthesis of stochastic nanoparticle surfaces with fluoro‐free moieties is investigated. Silicone (dimethyl and monomethyl) and hydrocarbon surface chemistries are benchmarked against perfluoroalkyls, assessed using model low‐surface‐tension liquids (ethanol–water mixtures). It is discovered that both hydrocarbon‐ and dimethyl‐silicone‐based functionalization can achieve super‐liquid‐repellency down to 40–41 mN m−1 and 32–33 mN m−1, respectively (vs 27–32 mN m−1 for perfluoroalkyls). The dimethyl silicone variant demonstrates superior fluoro‐free liquid repellency likely due to its denser dimethyl molecular configuration. It is shown that perfluoroalkyls are not necessary for many real‐world scenarios requiring super‐liquid‐repellency. Effective super‐repellency of different surface chemistries against different liquids can be adequately predicted using empirically verified phase diagrams. These findings encourage a liquid‐centric design, i.e., tailoring surfaces for target liquid properties. Herein, key guidelines are provided for achieving functional yet sustainably designed super‐liquid‐repellency.
Remote Water‐to‐Air Eavesdropping with a Phase‐Engineered Impedance Matching Metasurface
Authors: Liu Jingjing , Li Zhengwei , Liang Bin , Cheng Jian‐Chun , Alù Andrea 
Published: April 2023

AbstractEfficiently receiving underwater sound remotely from air is a long‐standing challenge in acoustics hindered by the large impedance mismatch at the water–air interface. Here, a phase‐engineered water–air impedance matching metasurface is proposed and experimentally demonstrated for remote and efficient water‐to‐air eavesdropping. The judiciously designed metasurface with near‐unity transmission efficiency, long monitoring distance, and high mechanical stiffness is capable of making the water–air interface acoustically transparent and, at the same time, freewheelingly patterning the transmitted wavefront. This enables efficient control over the effective spatial location of a distant airborne sensor such that it can measure underwater signals with large signal‐to‐noise ratios as if placed close to the physical underwater source. Such airborne eavesdropping of underwater sound is experimentally demonstrated with a measured sensitivity enhancement of nearly 104 at 8 kHz, far from achievable with the current state‐of‐the‐art methods. Moreover, the opportunities of using the proposed metasurface for cross‐media orbital‐angular‐momentum‐multiplexed communication and underwater acoustic window are also demonstrated. This metasurface opens new avenues for communication and sensing in inhomogeneities with totally reflective interfaces, which may be translated to nano‐optics and radio frequencies.
Highly Sensitive, Ultrawide Range, and Multimodal Flexible Pressure Sensor with Hierarchical Microstructure Prepared By a One‐Step Laser Printing Process
Authors: Lei Xiao , Guo Dingyi , Ye Lei , Xu Langlang , Yu Sinan , Tong Lei , Zhao Yiling , Li Yunfan , Yi Longju , Liu Feng 
Published: April 2023

AbstractThe hierarchical microstructures composed of surface microstructures and porous structures on soft materials have attracted more and more attention because of their effectiveness in improving flexible sensor performance. However, the preparation methods of the hierarchical microstructures are faced with the problems induced by complex process, high cost, and low efficiency. Up to now, there is no one‐step method that can directly realize the hierarchical microstructure on soft materials, even polydimethylsiloxane (PDMS) as the most common soft material. Herein, using glucose additive as porogen and endothermic agent, a simple, low‐cost, and fast laser thermal printing one‐step process is developed for the preparation of porous PDMS film with surface microstructure. Based on the hierarchical structural PDMS film, a multimodal flexible pressure sensor that can sense tension, compression, and torsion is realized. Due to the hierarchical microstructure composed of surface microstructure and porous structure, the sensor exhibits a high sensitivity of 36.66 kPa−1 in 0–0.6 kPa, a ultrawide sensing range of 3000 kPa, a 100% elongation, and a high gauge factor of 315.13. The application of the sensor in the monitoring of physiological signals, dynamic loads, and robotic flexible gripper demonstrates the potential of the laser thermal printing process in porous PDMS‐based sensors.
Broadside‐Coupled Split Ring Resonators as a Model Construct for Passive Wireless Sensing
Authors: Dia Kazi Khurshidi Haque , Hajiaghajani Amirhossein , Escobar Alberto Ranier , Dautta Manik , Tseng Peter 
Published: April 2023

AbstractPassive and wireless Radio‐Frequency (RF) sensors are a unique, enabling modality for emerging applications in environmental sensing. These sensors exhibit several key features that may unlock new functionalities in complex environments: sensors are composed of zero electronic components, are wirelessly interrogated even in opaque media, and structures are often inherently biocompatible. Such capabilities make it unique in the realm of sensing architectures. Here, the broadside‐coupled, split‐ring resonator is studied as a compact and versatile model structure for RF sensing (of potentially mechanical and biochemical environments). A new analytical model is derived to assess resonator behavior—these yield a rapid, first‐order approximation of the resonator resonant frequency or sensitivity. Finally, experimental investigations into how sensors may be optimally designed, sized, and interrogated to enhance sensitivity or spectral intensity are performed. These studies encompass a wide variety of potential dimensional and dielectric modifications that may be relevant to emerging sensors. Last, hydrogel polymeric sensors are synthesized and studied to assess how practical sensors may deviate in response from expectations. Such investigations lay the groundwork for how such sensing architectures may be adapted to fit application needs.
Blood β‐synuclein is related to amyloid PET positivity in memory clinic patients
Authors: Oeckl Patrick , Bluma Marina , Bucci Marco , Halbgebauer Steffen , Chiotis Konstantinos , Sandebring‐Matton Anna , Ashton Nicholas J. , Molfetta Guglielmo Di , Grötschel Lana , Kivipelto Miia , Blennow Kaj , Zetterberg Henrik , Savitcheva Irina , Nordberg Agneta , Otto Markus 
Published: April 2023

AbstractIntroductionβ‐synuclein is an emerging blood biomarker to study synaptic degeneration in Alzheimer´s disease (AD), but its relation to amyloid‐β (Αβ) pathology is unclear.MethodsWe investigated the association of plasma β‐synuclein levels with [18F]flutemetamol positron emission tomography (PET) in patients with AD dementia (n = 51), mild cognitive impairment (MCI–Aβ+ n = 18, MCI– Aβ– n = 30), non‐AD dementias (n = 22), and non‐demented controls (n = 5).ResultsPlasma β‐synuclein levels were higher in Aβ+ (AD dementia, MCI–Aβ+) than in Aβ– subjects (non‐AD dementias, MCI–Aβ−) with good discrimination of Aβ+ from Aβ– subjects and prediction of Aβ status in MCI individuals. A positive correlation between plasma β‐synuclein and Aβ PET was observed in multiple cortical regions across all lobes.DiscussionPlasma β‐synuclein demonstrated discriminative properties for Aβ PET positive and negative subjects. Our data underline that β‐synuclein is not a direct marker of Aβ pathology and suggest different longitudinal dynamics of synaptic degeneration versus amyloid deposition across the AD continuum.Highlights
Blood and CSF β‐synuclein levels are higher in Aβ+ than in Aβ− subjects.
Blood β‐synuclein level correlates with amyloid PET positivity in multiple regions.
Blood β‐synuclein predicts Aβ status in MCI individuals.
Controllable cross‐linking of VA‐co‐VAm/PAN composite membranes for efficient pervaporation desalination under extreme pH conditions
Authors: Fu Jiawen , Pan Haowei , An Mingzhe , Li Zihao , Wang Hong , He Xinping , Yi Chunhai 
Published: April 2023

AbstractPolyvinyl alcohol (PVA) is a promising membrane material for pervaporation (PV) desalination. However, the adjustment and control of the cross‐linking structure is still a challenge for PVA membrane. In this study, a novel pH‐resistant PVA‐based composite membrane for efficient pervaporation desalination was developed by precisely adjusting the cross‐linking behavior. Vinyl alcohol‐vinylamine copolymer (VA‐co‐VAm) containing both hydroxyl and amino groups was synthesized. Cross‐linking reaction was carried out based on the Schiff base reaction between amino groups (in VAm moiety) and glutaraldehyde (GA) under alkaline conditions. Cross‐linking degree of PVA selective layer was carefully controlled by adjusting the amino group content in copolymer. Results showed that membrane prepared with VA‐co‐VAm that containing 5 wt% N‐vinylformamide (NVF) displayed superior hydrophilicity and the largest free volume fraction. Pervaporation test indicated that the modified cross‐linking membrane showed good stability under extreme pH conditions. Specifically, under strong acid conditions (pH ~ 1) and alkaline conditions (pH ~ 14), the membrane showed excellent desalination performance with water flux over 12 kg/(m2 h), and the salt rejection higher than 99.95%. Based on the above results, the prepared membrane offers a promising platform for desalination under extreme pH conditions, which shows great potential in industrial wastewater treatment.
Functionalized magnesium hydroxide with zinc borate and 3‐aminopropyltriethoxysilane for enhanced flame retardant and smoke suppressant properties of epoxy resins
Authors: Li Ping , Li Lijuan , Ji Lianmin , Dang Li , Lan Shengjie , Zhu Donghai 
Published: April 2023

AbstractTo improve the fire safety of epoxy resins (EP), a composite with magnesium hydroxide loaded zinc borate (MH@ZBO) was obtained using a heterogeneous deposition method, and then 3‐aminopropyltriethoxysilane (APES) was grafted onto the surface of MH@ZBO to produce an organic–inorganic hybrid (MH@ZBO‐APES). Subsequently, the EP composite with added MH@ZBO‐APES was prepared and its thermal properties and fire safety were evaluated. The results showed that the glass transition temperatures of the EP/MH@30ZBO‐10APES composite are improved, and the maximum thermal decomposition rate decreased, and the samples exhibited favorable thermal stability and flame‐retarding performance (flame retardancy index: 2.40; LOI: 33%). The enhanced fire safety was a result of two factors. On one hand, the endothermic decomposition of MH and ZBO and the physical barrier of their decomposition products, the catalytic carbonization function of ZBO, the synergistic flame retardation of APES, and its improvement in dispersion to form a denser carbon layer, which plays a role in fire retardation and smoke suppression in the condensed phase. On the other hand, water vapor produced by the decomposition of MH and ZBO, as well as incombustible gas produced by the degradation of APES, are vital in the gas phase.
Application of a Quality by Design‐based approach in development and validation of an RP‐HPLC method for simultaneous estimation of methotrexate and mangiferin in dual drug‐loaded liposomes
Authors: Adin Syeda Nashvia , Gupta Isha , Aqil Mohd. , Mujeeb Mohd. , Najmi Abul Kalam 
Published: April 2023

AbstractThe present study delineates the development of a novel rugged and sensitive stability‐indicating risk‐based HPLC method for the concurrent estimation of methotrexate and mangiferin in dual drug‐loaded nanopharmaceuticals based on an analytical QbD approach. Preliminary screening trials along with systemic risk analysis were performed, endeavouring to explicate the critical method attributes, namely pH, percentage orthophosphoric acid content and percentage methanol content, that influence critical quality attributes. Box–Behnken design was utilized for the optimization of the tailing factor as response for methotrexate and mangiferin in short run time. The chromatographic conditions were optimized by performing 17 experimental runs acquired from Design‐Expert software. The chromatographic conditions after the analysis of an optimized zone within the confines of the design space were chosen as mobile phase water–methanol adjusted to pH 3.0 with 0.05% orthophosphoric acid (65:35, v/v) and flow rate 1.0 ml/min using a C18analytical column at an isosbestic wavelength of 265 nm. Furthermore, the validation of the optimized method was done in accordance with International Conference on Harmonization guidelines and were reckoned to be in the prescribed limits. The developed RP‐HPLC method has a high degree of practical utility for synchronous detection of methotrexate and mangiferin in pharmaceutical nano‐dosage forms such as protein‐based‐nanoparticles, nanocrystals, polymeric nanoparticles and metallic nanoparticles inin vivoandin vitrostudies.
The impact of green marketing on collective behaviour: Experimental evidence from the sports industry
Authors: Gionfriddo Gianluca , Rizzi Francesco , Daddi Tiberio , Iraldo Fabio 
Published: April 2023

AbstractThis paper aims to investigate how supporters perceive and react to environmental messages that call for reducing the environmental impact of sporting events. Based on prospect theory, we randomly provided 1423 supporters attending football events in Europe with (1) a negative (perceived loss for supporters), (2) a neutral (no perceived gain or loss) or a (3) a positive (perceived gain for supporters) environmental message and measured their attitudes towards the message, pro‐environmental behavioural intentions and perceived consumer effectiveness. Our results reveal that supporters show traits of collective behaviour during sports events that may lower the in‐stadium effectiveness of environmental messages. The environmental commitment of the favoured sports club increases the influence of green marketing on supporters with higher levels of environmental values and knowledge, but only when they depart from a collective identity. This paper contributes to green marketing literature revealing that modelling collective behaviours of members of groups exposed to highly emotional situations should be coordinated with information and awareness‐raising campaigns in everyday life. We also contribute to the prospect theory showing that loss aversion prevails in risk‐free conditions even though it does not directly shape supporters' behavioural intentions.
Osteosarcoma of the mandible: A case with a clinical appearance similar to benign lesions
Authors: Pakfetrat Atessa , Zamani Toktam , Anbiaee Najmeh , Mirhashemi Majid , Vazavandi Elahe 
Published: April 2023

AbstractA 34‐year‐old woman with complaints of mandibular swelling that started 4 months earlier was referred to the Oral Diseases Department. Based on the clinical and radiographic appearance, the primary diagnosis was an intraosseous reactive lesion. However, the result of histopathology indicated osteosarcoma.
Traumatic herniation of buccal fat pad into the oral cavity in an infant: A case report
Authors: Abulohoom Faisal , Al‐wageeh Saleh , Ahmed Faisal , Al‐Sharani Hesham , Al‐Muaalemi Zakarya , Al‐Hutbany Nassr , Badheeb Mohamed 
Published: April 2023

AbstractBuccal fat herniation is a rare traumatic disease that should be included in differential diagnosis of infants' oral cavity mass. History of proceeding trauma, careful evaluation of mucosal perforation aiding the diagnosis.
Tramadol‐induced intracerebral hemorrhage: A rare case report
Authors: Sidow Nor Osman , Osman Mohamed Farah , Hassan Mohamed Sheikh , Ahmed Abdulkadir , Ibrahim Abdiwahid Ahmed 
Published: April 2023

AbstractA previously healthy middle‐aged man with no vascular risk factors developed a hemorrhagic stroke. He had been using tramadol due to erectile dysfunction for 2 years. So, the patient developed right basal ganglia due to tramadol addiction.