bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal stress-induced behavioral changes diminished by maternal exposure to an electromagnetic field (50 Hz, 100 µTesla) in male rat offspring
Authors: Farid-Habibi Mahsa , Mohaddes Gisou , Abkhezr Hajar , Farajdokht Fereshteh , Heydari Hamed , Babri Shirin 
Published: March 2023

Abstract

Prenatal exposure to stress predisposes offspring to mental health problems in adulthood. However, the underlying mechanisms remain obscure. The prefrontal cortex's (PFC) role is vital in regulating sleep and mood. Cryptochrome type 2 (CRY2), as a magnetoreceptor and an important part of the circadian system, has been linked to depression and anxiety. We aimed to determine CRY2 role in prenatal stress and extremely low-frequency electromagnetic fields (ELF-EMF) on the PFC of rat offspring and its relationship with behavior. Female Wistar rats were exposed to chronic mild stress (CMS) or electromagnetic field (EMF) (50 Hz, 100 μT, 4 h/day) for 21 days before and during pregnancy. Behavioral tests, including the elevated plus maze, open field, and forced swimming test, were conducted on the male offspring at postnatal day (PND) 80, 81, 90. The expressionof CRY2 in the PFC and levels of serum corticosterone (CORT) were also measured. The results showed that maternal stress exposure caused anxiety- and depression-like behaviors in the male offspring, accompanied by decreased prefrontal CRY2 protein expression and increased serum CORT levels. In addition, maternal EMF had no significant effect on CRY2 expression in the male offspring. However, parallel ELF-EMF and stress exposure significantly attenuated anxiety and depression-like behaviors and decreased serum CORT levels.
Sugar-Sweetened Beverage Consumption and associated factors among women aged 10-49 years old in two Sub-Saharan African Countries
Authors: Semagn Birhan Ewunu , Abubakari Abdulai , Kebede Shimels Derso 
Published: March 2023

Abstract
Background: The consumption of Sugar-Sweetened Beverages (SSBs) has been linked to the global epidemic of obesity and chronic disease .Following the economic growth, urbanization, and attractive market for beverage companies, the consumption of Sugar sweetened beverage is a rising public health challenge in low and middle-income countries. There is a paucity of evidence on the prevalence and factors associated with the consumption of SSBs in Sub-Saharan Africa.
Methods: This cross-sectional study used data from IPUM-PMA with a total sample of 4822 women aged 10-49 years old in Burkina Faso and Kenya. After accessing the data from the IPUM-PMA website data re-coding, and labeling were done and analysed using STATA Version 14. Mixed effect logistic regression model was employed to identify associated factors.
Result: Almost half (49.08%) [44.65, 53.53] of women consumed sugar-sweetened beverages. Primary education (AOR = 1.27; 95%CI: 1.01 – 1.59), secondary education (AOR = 1.47; 95%CI: 1.15 – 1.87), employment status (AOR = 1.22; 95%CI: 1.01 – 1.48),consumption of savory and fried snack(AOR=1.64, ;95%CI=1.29 – 2.07 ,achieved minimum dietary diversity (AOR = 1.77; 95%CI: 1.50 – 2.08) ,highest wealth score (AOR = 1.40, 95% CI: 1.04, 1.18) , moderate household food insecurity (AOR = 0.78, 95% CI: 0.62, 0.97), and sever household food insecurity (AOR = 0.74, 95% CI: 0.61, 0.91) were statistically significantly association with Sugar-Sweetened Beverage consumption.
Conclusion: Consumption of SSBs among women in Africa is increasing and associated with high socio-economic class. Tailored public health intervention targeting middle to high-income groups will help curb the rise in the burden of morbidity and mortality following obesity and other non-communicable diseases among women in Africa.
Anaesthetic management of thoracotomy for massive intrathoracic solitary fibrous tumor of the pleura: a case report
Authors: Shen Wang , Li Yan , Liu Feng , Liu Ning , Wang Xiangrui , Ji Zhonghua 
Published: March 2023

Abstract
Backgrounds: Solitary fibrous tumor of the pleura (SFTP) is a rare thoracic tumor and usually asymptomatic. Massive SFTP may affect adjacent organs and tissues including pulmonary vasculature, bronchus and heart. A thoracotomy for massive SFTP is necessary in severe case. Therefore, it is important for anaesthesiologists to understand the condition of patients with massive SFTP and develop an appropriate anesthetic management strategy. Case summary: A 76-year-old woman with massive SFTP presented to our clinical center and was evaluated as requiring thoracotomy. She received multidisciplinary cooperation treatment from the radiology, cardiac, thoracic surgery and anaesthetic teams. The perioperative management of anaesthesiologists played a crucial role in the great prognosis of this woman. Conclusions: This case report demonstrates the importance of comprehensive and meticulous perioperative management and provides guidance to the multidisciplinary team on the potential risk and the rational treatment strategy of patients with massive SFTP during the perioperative period.
A first exploratory comparison of the behaviour of wolves (Canis lupus) and wolf-dog hybrids in captivity
Authors: Amici Federica , Meacci Simone , Caray Emmeline , Oña Linda , Liebal Katja , Ciucci Paolo 
Published: March 2023

Abstract

Extensive introgression of genes from domesticated taxa may be a serious threat for the genomic integrity and adaptability of wild populations. Grey wolves (Canis lupus) are especially vulnerable to this phenomenon, but there are no studies yet assessing the potential behavioural effects of dog-introgression in wolves. In this study, we conducted a first systematic comparison of admixed (N = 11) and non-admixed wolves (N = 14) in captivity, focusing on their reaction to unfamiliar humans and novel objects, and the cohesiveness of their social groups. When exposed to unfamiliar humans in the experimental task, wolves were more vigilant, fearful and aggressive than admixed wolves, and less likely to approach humans, but also more likely to spend time in human proximity. When exposed to novel objects, wolves were more aggressive than admixed wolves, less likely to spend time in object proximity, and more likely to interact with objects, but also less vigilant and as fearful as admixed wolves. Finally, social networks were mostly more cohesive in wolves than admixed wolves. Overall, our study suggests that dog admixture may lead to important behavioural changes in wolves, with possible implications for conservation strategies.
Factors affecting the length of hospital stay for total knee arthroplasty: a retrospective database study using Diagnosis Procedure Combination
Authors: Hara Kentaro , Kanda Masato , Kobayashi Yoshio , Miyamoto Takashi , Inoue Takahiro 
Published: March 2023

Abstract
This retrospective observational study on the length of stay for total knee arthroplasty was conducted at our institution to determine the impact of relevant factors from the Diagnosis Procedure Combination data. The study cohort included 5831 patients who had osteoarthritis of the knee and had undergone total knee replacement from February 2018 to October 2022 in 38 hospitals. Multivariate analysis showed that factors influencing length of stay include: age (p < 0.001), height (p < 0.001), weight (p = 0.049), body mass index (p = 0.008), Barthel index (p < 0.001), method of anesthesia (p < 0.001), bone transplant (p = 0.010), timing of postoperative rehabilitation (p < 0.001), atrial fibrillation (p < 0.001), chronic pain (p < 0.001) and the number of institutionally treated cases (p < 0.001) (r = 0.451, p < 0.001). Shorter or longer hospital stays were found to be associated with patients' backgrounds and facility factors, which can lead to more accurate estimates of the length of stay and appropriate allocation of resources.
A modified pull-through approach with a pedicled bone flap for oral and oropharyngeal cancer resection - a cadaveric feasibility study
Authors: Neckel Norbert , Neckel Peter , Hirt Bernhard , Doll Christian , Hofmann Elena , DDS Susanne Nahles , Heiland Max , Kreutzer Kilian , Koerdt Steffen 
Published: March 2023

Abstract
Purpose
Compromised swallowing and speaking as well as local complications are the major disadvantages of established approaches to the posterior tongue and oropharynx. The mandibular split involves an esthetically unpleasant bipartition of the lower lip and is prone to bony non-union or sequestration. The traditional pull-through technique on the other hand lacks the safe reattachment of the lingually released soft tissues.
Methods
The feasibility of a new modified pull-through approach was tested on three anatomical specimens. CAD/CAM cutting guides were used to design a retentive bone flap for the proper refixation of the genioglossus and geniohyoid muscles after the procedure.
Results
Precise repositioning and dynamic compression of bony segments was reproducible and no injury to adjacent structures occurred. In all cases, a median lingual foramen was found and in two cases vessels entering it could be dissected.
Conclusion
The method presented is safe and easy to perform. Individual cutting guides improve the safety and accuracy of the procedure, potentially eliminating the need for osteosynthesis. We provide the anatomical and radiologic basis for clinical evaluation of this pedicled bone flap procedure.
Effects of foot reflexology on an infant with SNHL: An fMRI case study
Authors: LEE Yujun , Chen Maoqing , HaoYan  
Published: March 2023

Abstract
Foot reflexology is a traditional medicine in which foot stimulation is believed to have therapeutic effects on patients with sensorineural hearing loss (SNHL). However, no physiological evidence of these benefits is available. In the present study, functional magnetic resonance imaging (fMRI) was employed to assess the effects of foot reflexology. Compared with SNHL infants who did not undergo foot reflexology, an SNHL infant treated with foot reflexology exhibited increased regional homogeneity (ReHo) in the frontal cortex, temporal cortex, occipital cortex, and thalamus and decreased ReHo inthe bilateral occipital cortex. This suggests that foot reflexology influences hubs of the brain networks responsible for language and auditory processing. Differences in these areas have clinical significance and may be helpful for treating infants with SNHL.A large-scale, randomized controlled trial is needed to confirm these findings.
Vertebral fractures cascade: potential risk factors
Authors: fan yuyu , fang xiutong , Ding LIxiang , Song Hongxing , Qiao Junjie , Hou Yu , Yi Meng 
Published: March 2023

Abstract
Vertebral fractures (VFs) are the most common osteoporotic fractures and are a strong risk factor for subsequent VFs, leading to VF cascade (VFC). We conducted a study to identify potential causes of and risk factors for VFC. At the same time, we also studied the factors influencing the time between fractures in patients with osteoporotic VFC. We retrospectively analysed the clinical data of 889 patients diagnosed with osteoporotic vertebral fracture at Beijing Shijitan Hospital affiliated with Capital Medical University from January 1, 2015, to December 31, 2022. The study included 193 patients with VFC. The multifactorial risk analysis showed that the independent risk factors for VFC included a history of diabetes mellitus (hazard ratio, 1.635; p value = 0.016), a history of oral corticosteroid therapy (hazard ratio, 1.798; p value = 0.001), chronic obstruction pulmonary disease (COPD, hazard ratio 1.666, p value = 0.036), thoracolumbar fracture (hazard ratio, 2.664, p value < 0.001), and a body mass index (BMI) ≥ 28 (hazard ratio 1.421; p value = 0.045). Further study showed that glycated haemoglobin was also an important factor affecting the interval between fractures in patients with VFC. Independent risk factors for VFC include a history of diabetes, prior oral corticosteroid therapy, COPD, thoracolumbar fracture, and BMI ≥ 28. The occurrence of fractures in the thoracolumbar segment is the most important risk factor. Additional research has shown that after the first vertebral fracture, the poorer the patient's blood sugar control, the faster the refracture rate.
Effect of fenofibrate and gemfibrozil on kynurenic acid production in rat kidney in vitro: old drugs, new possibilities
Authors: Zakrocka Izabela , Załuska Wojciech 
Published: March 2023

Abstract
Kidney dysfunction significantly increases cardiovascular risk, even in the setting of minor function decline. Hypertriglyceridemia is the most common finding among lipid abnormalities in patients with kidney disorders. PPARα (peroxisome proliferator-activated receptor-α) agonists called fibrates are main agents used to lower triglycerides level. Kynurenic acid (KYNA) is one of tryptophan (Trp) metabolites, directly formed from L-kynurenine (L-KYN) by kynurenine aminotransferases (KATs). KAT I and KAT II are the best studied KAT isoenzymes. KYNA is classified as a uremic toxin, which level correlates with kidney function decline. High fat diet, known as ketogenic diet, was previously shown to increase KYNA concentration. Purpose: The aim of this study was to analyze the effect of most commonly used fibrates, fenofibrate and gemfibrozil, on KYNA production and KATs activity in rat kidney in vitro. Methods: The influence of fenofibrate and gemfibrozil on KYNA synthesis, as well as both KATs activity, was tested in rat kidney homogenates in vitro after 2 hours incubation in the presence of KYNA precursor and selected drug. Each drug was examined at increasing concentrations up to 1 mM. KYNA formation was analyzed through high performance liquid chromatography (HPLC). Results: Fenofibrate and gemfibrozil significantly decreased KYNA synthesis and both KATs activity in rat kidney in vitro. Conclusion: Fenofibrate and gemfibrozil decrease KYNA production in rat kidney in vitro through inhibition of KAT I and KAT II isoenzymes. Presented results show novel mechanism of fibrates action in the kidney, indicating potential role of examined drugs in kidney function regulation.
Brumimicrobium oceani sp. nov., isolated from coastal sediment saline lake and Genome Insight of the Genus Brumimicrobium
Authors: Zhang Meng-Di , Zhou Zi-Yang , Kou Yi-Yu , Lu De-Chen , Du Zong-Jun 
Published: March 2023

Abstract
A novel Gram-stain-negative, aerobic, non-motile, rod-shaped and orange-colored bacterium, designated as strain C305T, was isolated from marine sediment of the coast area of Weihai, China. Strain C305T growth occurs at 4–40 °C (optimally at 30–33 °C), pH 6.0–9.0 (optimally at pH 8.0) and with 0.5–10.0 % (w/v) NaCl (optimum 1.5–3.0 %). No growth is observed without NaCl. The major cellular fatty acids of strain C305T were identified as iso-C15:0 ，iso-C15:1G and iso-C17:0 3-OH. The major respiratory quinone was found to be MK-6, and the DNA G+C content was determined to be 35.5mol %. The predominant polar lipids were mainly Phosphatidylethanolamines (PE), unidentified aminophospholipids (APL), and a kind of unidentified lipid (L2). Phylogenetic analysis based on 16S rRNA gene sequences revealed that C305T was a member of the genus Brumimicrobium and had a 16S rRNA gene sequence similarity values of 96.9–98.0 % with recognized Brumimicrobium species. On the basis of the phylogentic and phenotypic evidences, strain C305T represents a novel species of the genus Brumimicrobium, for which the name Brumimicrobium oceani sp. nov. is proposed. The type strain is C305T (= KCTC 62371T =MCCC 1H00297T).
A Power-Balanced Alamouti Scheme with Security Protection
Authors: Chan Satya , Lee Hyein , Kim Sooyoung 
Published: March 2023

Abstract
Due to advancements in modern mobile communication technology, massive numbers of devices are now connected to the internet, but the associated information also has to be well protected. Many studies have proposed physical layer security (PLS) approaches utilizing artificial noise (AN), which is a simple approach to protecting information from an illegal receiver. However, this approach requires additional power allocation for AN. This paper proposes an efficient power balancing method for the Alamouti scheme, which provides efficient security capability as well as enhancement of power efficiency. The simulation results investigated in this paper reveal that the proposed scheme requires about 5 dB smaller power to achieve the same performance as that of the conventional AN-aided scheme, and eventually, about 2 dB less power than the conventional scheme without PLS.
Monotherapy is associated with a lower risk of mortality in patients infected with carbapenem-resistant Enterobacteriaceae without sepsis
Authors: Deng Sheng , Chen Jinglan , Zhou Pengxiang , Hu Qin 
Published: March 2023

Abstract
Background: To determine the mortality-related risk factors for carbapenem-resistant Enterobacteriaceae (CRE) infection in hospitalized patients and to compare the clinical efficacy of different antimicrobial regimens, mainly from the perspective of mortality.
Methods: Data were retrospectively collected from a 3,000-bed regional medical center with CRE infections between January 2021 and June 2022. The clinical characteristics, microbiological characteristics, and antimicrobial therapies of the patients with different outcomes were analyzed. Mortality-related risk factors were analyzed by the Cox proportional regression model for multivariate analysis.
Results: 120 patients were included. All patients received definitive therapy, and 65.0% (78/120) received active drug treatment. Among those receiving active drug treatment, 65.4% (51/78) received combination therapy, and 34.6% (27/78) received monotherapy. The all-cause mortality of CRE infection was 20.8% (25/120). Multivariate analysis showed that the length of hospital stay after CRE infection (hazard ratio [HR], 0.868; 95% confidence interval [CI], 0.806-0.936; P = 0.000), Sequential Organ Failure Assessment (SOFA) score (HR = 1.169; 95%CI, 1.066-1.281; P = 0.001), central venous catheter (HR = 3.858; 95%CI, 1.411-10.547; P = 0.009), age (HR = 1.035; 95%CI, 1.002-1.070; P = 0.036), and combination therapy (HR = 3.152; 95%CI, 1.205-8.245; P = 0.019) were independent mortality risk factors after CRE infection. Subgroup analysis of the non-sepsis group among 78 patients who received active drug treatment showed significantly lower mortality in monotherapy than in combination therapy (0% versus 22.2%, P = 0.034). Patients who received carbapenem-containing therapy had significantly higher mortality than those who received carbapenem-sparing therapy (31.3% versus 13.9%, P = 0.022).
Conclusions: Patients with a higher SOFA score, central venous catheter, shorter hospital stay after CRE infection, older age, and combination therapy had poor outcomes. Since patients with non-sepsis have a lower mortality rate from monotherapy, combination antibiotic treatment should not be routinely recommended to treat CRE infections.
18-Crown-6 based supramolecular structure, hydrogen bonding behaviour and its nonlinear optical properties
Authors: Chellakarungu Balakrishnan , Muniyasamy Manonmani , Govindarajan Vinitha , Meenakshisundaram Subbiah 
Published: March 2023

Abstract
Self-assembled supramolecular cocrystals of (18-crown-6).2(5-amino-2,4,6-triiodoisophthalic acid).2(H2O) has been synthesised from 18-crown-6 (18C6) and 5-amino-2,4,6-triiodoisophthalic acid (5ATIPA) by slow evaporation solution growth technique. The cocrystal was characterized by IR, DRS and PL spectroscopy, single-crystal X-ray diffraction and z-scan technique. It crystallizes in a monoclinic system with centrosymmetric space group P21/c. Supramolecular assembly is constructed by N─H•••O and O─H•••O interactions. The inclusion of the water molecules is involved in bifurcated hydrogen bonds with the 18C6 molecule and the -NH2 group is involved in intramolecular hydrogen bonds with iodine atoms of the 5ATIPA molecule. The vibrational patterns in FT–IR is used to identify the functional groups. Direct band gap energies estimated by diffuse reflectance spectrum is, 3.13 eV. Fingerprint plots of Hirshfeld surfaces were used to locate and analyze the percentage of hydrogen bonding interactions. The z-scan technique indicates the suitability of cocrystal for third-order NLO applications.
Staged osteotomy in lateral position for the treatment of severe kyphotic deformity secondary to ankylosing spondylitis: a retrospective study
Authors: Hu Zhengjun , Zhong Rui , Zhao Deng , Wang Fei , Huang Huaqiang , Jiang Dengxu , Zhang Zhong , Liang Yijian 
Published: March 2023

Abstract
Background
Patients are often complicated with severe kyphotic deformity (Cobb > 100 °) in the advanced stage of ankylosing spondylitis (AS). Corrective osteotomy based on a prone position seems to be the only effective treatment. Even with a specifically prepared folding bed, it can occasionally be challenging to prone-position AS patients with severe kyphosis.
Methods
23 patients who underwent staged osteotomy in a lateral position from October 2015 to June 2017 were analyzed. In the first stage of surgery, all but one patient underwent a single-level Ponte osteotomy, which was followed by a pedicle subtraction osteotomy in the second stage. The average follow-up was 30.8 ± 4.6 months. Global kyphosis (GK), thoracic kyphosis (TK), lumbar lordosis (LL), sagittal vertical axis (SVA), osteotomized vertebra intervertebral angle (OVI), Chin-brow vertical angle (CBVA), Oswestry Disability Index (ODI) score and Scoliosis Research Society-22 Patient Questionnaire (SRS-22) were all compared pre-and post-operation.
Results
All kyphosis parameters were significantly improved (all P < 0.05). GK was corrected from 115.0 ± 13.4 ° to 46.5 ± 9.0 ° postoperatively, with a mean correction of 68.5 °. SVA was improved from 21.2 ± 5.1 cm to 5.1 ± 1.8 cm postoperatively. After surgery, CBVA was adjusted from 64.1 ± 23.2 ° to 5.7 ± 10.6 ° and OVI was changed from 9.0 ± 2.7 ° to -20.1 ± 5.6 °. Both the ODI and SRS-22 showed substantial improvements (all P < 0.05). Four patients with mild complications were observed perioperatively.
Conclusion
In AS patients with severe kyphosis, satisfactory correction can be safely achieved with staged osteotomy in the lateral decubitus position, which can not only correct the sagittal imbalance of the spine with acceptable complications but also facilitate the placement of intraoperative position.
MEAI:An Artificial Intelligence Platform For Predicting Distant And Lymph Node Metastases Directly From Primary Breast Cancer
Authors: Fan Jiansong , Zhang Lei , Lv Tianxu , Liu Yuan , Sun Heng , Miao Kai , Jiang Chunjuan , Li Lihua , Pan Xiang 
Published: March 2023

Abstract
Purpose: Breast cancer patients typically have decent prognoses, with a 5-year survival rate of more than 90\%, but when the disease metastases to lymph node or distant, the prognosis drastically declines. Therefore, it is essential for future treatment and patient survival to quickly and accurately identify tumor metastasis in patients. An artificial intelligence system was developed to recognize lymph node and distant tumor metastases on whole-slide images (WSIs) of primary breast cancer.
Methods: In this study, a total of 832 WSIs from 520 patients without tumor metastases and 312 patients with breast cancer metastases (including lymph node, bone, lung, liver, and other) were gathered. Based on the WSIs were randomly divided into the training and testing cohorts, a brand-new artificial intelligence system called MEAI was built to identify lymph node and distant metastases in primary breast cancer.
Results: The final AI system attained an area under the receiver operating characteristic curve of 0.934 in a test set of 187 patients. In addition, the potential for AI system to increase the precision, consistency, and effectiveness of tumor metastasis detection in patients with breast cancer was highlighted by the AI's achievement of an AUROC higher than the average of six board-certified pathologists (AUROC: 0.811) in a retrospective pathologist evaluation.
Conclusion: The proposed MEAI system can provide a non-invasive approach to assess the metastatic probability of patients with primary breast cancer.