bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Higiene dan Sanitasi Industri Rumah Tangga Pengolahan Tahu di Kelurahan Bara-Baraya Kota Makassar
Authors: Dini Dwi Pratiwi Chaerul  , Muhammad Khidri Alwi  , Ikhram Hardi S  
Published: July 2023

Hygiene dan sanitasi industri adalah upaya pencegahan atau preventif yang perlu dilakukan pada setiap industri untuk menjaga dan memelihara kesehatan lingkungan serta mengendalikan faktor-faktor dari lingkungan yang muncul di tempat kerja atau industri yang dapat menyebabkan pekerja dapat mengalami gangguan kesehatan dan rasa ketidaknyamanan pada saat melakukan pekerjaan. Jenis penelitian ini adalah yang digunakan dalam penelitian ini adalah kuantitaif dengan pendekatan deskriptif. Populasi dalam penelitian ini adalah seluruh pekerja yang ada di 2 industri tahu di Kelurahan Bara-Baraya Jl. Inspeksi Kanal dengan teknik total sampling yaitu sebanyak 30 responden yang ada di 2 industri tahu. Data dianalisis menggunakan univariat untuk mendeskripsikan karakteristik responden serta menganalisa setiap variabel. Hasil penelitian menujukkan hampir seluruh pekerja di 2 industri yang belum memperhatikan kebersihan dirinya dan tidak menggunakan alat pelindung diri yang lengkap dan hampir 100% lingkungan kerja industri tidak memelihara serta menjaga kesehatan lingkungannya dan untuk pengolahannya telah menggunakan mesin yang masih layak pakai, Disarankan kepada pekerja agar memakai alat pelindung diri ketika bekerja dan memperhatikan kebersihan serta kesehatan diri. Diharapkan pada pemilik industri tahu agar lebih menerapkan lagi mengenaik hygiene dan sanitasi pada lingkungan industri serta para pekerjanya agar hasil olahan tahu tetap aman dan bersih serta pekerjanya sehat dan selamat.
Faktor yang Berhubungan dengan Pemanfaatan Pelayanan Kesehatan Posyandu Lansia di Puskesmas Wara Selatan Kota Palopo
Authors: Sartika Nganro  , Nurfardiansyah Bur  , Nurgahayu  
Published: July 2023

Lanjut usia adalah suatu kejadian yang pasti akan dialami oleh semua orang yang dikaruniai usia panjang terjadinya tidak bisa dihindari oleh siapapun. Para lansia seharusnya memanfaatkan adanya posyandu lansia dengan baik, agar kesehatan para lansia dapat terpelihara dan terpantau secara optimal. Namun pada kenyataannya tidak semua lansia memanfaatkan adanya kegiatan posyandu lansia. Tujuan penelitian ini adalah untuk menganalisis factor yang berhubungan dengan pemanfataan pelayanan kesehatan posyandu lansia di Puskesmas Wara Selatan Kota Palopo Palopo. Jenis penelitian ini adalah kuantitatif dengan desain penelitian yang bersifat cross sectional, serta sampel sebesar 112 orang. Jenis data yang dikumpulkan di wilayah kerja Puskesmas Wara Selatan Kota Palopo dianalisis dengan uji chi-square dengan derajat kemaknaan (α) = 0,05. Hasil analisis menunjukkan bahwa ada hubungan pengetahuan lansia dengan pemanfaatan posyandu lansia, ada hubungan sikap lansia dengan pemanfaatan posyandu lansia, tidak ada hubungan dukungan keluarga dengan pemanfaatan posyandu lansia, ada hubungan dukungan kader dengan pemanfaatan posyandu lansia, ada hubungan akses keterjangkauan dengan pemanfaatan posyandu lansia. Saran untuk pihak puskesmas agar lebih giat melakukan penyuluhan tentang posyandu lansia, serta mengevaluasi kinerja kader posyandu. Penempatan lokasi posyandu lansia harus berada di tempat yang strategis, dan untuk para lansia agar selalu merespon positif dan ikut serta dalam kegiatan kegiatan posyandu lansia untuk menjaga dan mengontrol kesehatan.
Hubungan Perilaku 3M Plus Ibu Rumah Tangga dengan Keberadaan Jentik Aedes Aegypti di Wilayah Kerja Puskesmas Antang Perumnas Kota Makassar
Authors: Nurlailah  , Rahman  , Ulfa Sulaeman  
Published: July 2023

Upaya yang paling efektif untuk pemberantasan jentik adalah melakukan pemutusan mata rantai penularan yaitu (PSN) dengan kegiatan yang sering disebut 3M plus. Tujuan penelitian adalah untuk mengetahui hubungan perilaku 3M plus ibu rumah tangga dengan keberadaan jentik Aedes aegypti di wilayah kerja Puskesmas Antang Perumnas. Jenis penelitian yang digunakan adalah observasional dengan rancangan cross sectional study. Jumlah populasi 32, Teknik pengambilan sampel yaitu (total sampling) rumah penderita dan tetangga (kanan dan kiri), jumlah sampel sebanyak 96. Hasil penelitian ini menunjukkan bahwa karakteristik hubungan pengetahuan dengan keberadaan jentik dari hasil uji chi-square yaitu ρ=0.103 karena 0.103>0.05 tidak ada hubungan, hubungan antara sikap dengan keberadaan jentik diperoleh hasil uji chi-square yaitu ρ=0.549 karena 0.549>0.05 sehingga tidak ada hubungan, hubungan antara tindakan dengan keberadaan jentik yaitu ρ=0,173 karena 0,173>0,05 tidak ada hubungan. tidak ada hubungan perilaku ibu rumah tangga dengan pengetahuan, sikap dan tindakan dengan keberadaan jentik. Perlunya informasi tambahan untuk tetap mempertahankan pengetahuan, sikap dan tindakan ibu rumah tangga tentang 3M Plus untuk mencegah berkembang biaknya jentik.
COLLABORATIVE GOVERNANCE BUMD DESA MARGAASIH KABUPATEN BANDUNG
Authors: Permatasari Arini 
Published: July 2023

Governance or collaboration between governments has not been fully implemented. It is evident that there is still a discrepancy in the implementation of good cooperation between people and the bumdes themselves. The study is intended to know how the public collaboration with the municipal business can can be made in the village of can can be kept alive. The research methods used are qualitative methods with natural characteristics as direct data sources. Data collection techniques are conducted by observation, interview and documentation, the data analysis techniques used for data reduction, data presentation and deduction. The study is tested by the abstract governance theory presented by Ansell and Gash, by the indicator of face to face dialogue, trust building, commitment to process, share understanding, and intermediate elections. The results of the study show that the efforts made by the Village and BUMDes carry out socialization and provide business training to people who already have a business, and are just starting a business, as well as reminding them to repay loans and hope that there will be growing awareness of the community or business actors in the obligation to pay loans, also public awareness about Bumdes which makes people take advantage of business opportunities with assistance from the Bumdes themselves.AbstrakCollaborative Governance atau kolaborasi antar pemerintahan belum sepenuhnya dijalankan. Dapat dilihat dari masih adanya ketidaksesuaian pada pelaksanaan kerjasama yang baik antara masyarakat dengan Bumdes itu sendiri. Penelitian ini bertujuan untuk mengetahui sejauh mana kolaborasi masyarakat terhadap badan usaha milik daerah dalam miningkatkan keberadaan Bumdes di Desa Margaasih. Penelitian ini menggunakan metode kualitatif. Teknik pengumpulan data dilakukan dengan cara observasi, wawancara dan dokumentasi, sementara teknik analisis data yang digunakan yaitu reduksi data, penyajian data dan penarikan kesimpulan. Penelitian ini diuji dengan teori Collaborative Governance yang dikemukakan oleh Ansell dan Gash, yaitu dari indikator face to face dialogue (dialog tatap muka), trust building (membangun kepercayaan), commitment to process (komitmen terhadap proses), share understanding (pemahaman bersama), dan intermediate outcomes (hasil antara). Hasil penelitian menunjukkan bahwa upaya-upaya yang dilakukan oleh desa dan BUMDes melakukan sosialisasi dan memberikan pelatihan usaha kepada masyarakat yang sudah memiliki usaha, dan baru memulai usaha, serta mengingatkan untuk membayar pinjaman serta harapan agar tumbuhnya kesadaran masyarakat atau pelaku usaha dalam kewajiban membayar pinjaman, juga kesadaran masyarakat tentang Bumdes yang membuat masyarakat menjadi memanfaatkan peluang adanya usaha dengan bantuan daripada Bumdes itu sendiri.
Controle biológico de doenças foliares na soja
Authors: Abrantes Matheus Faria , Marques Mônica Lau da Silva , Santos Tassia Tuane Moreira dos , Jesus Jéssica Maria Israel de , Martins Adriana Lau da Silva , Sousa Antônio Evamir Cavalcante , Rangel Wesley de Melo 
Published: July 2023

A cultura da soja vem se destacando cada vez mais no cenário nacional. Grandes avanços e melhorias na produtividade foram alcançados. No entanto, ainda há fatores limitantes que influenciam seu desempenho, principalmente as doenças foliares. Sendo assim, o presente trabalho teve como objetivo avaliar o desempenho do biofungicida, Bacillus subtilis BV02, no controle de doenças foliares da soja. O ensaio foi realizado na estação experimental da Semear, Campinorte – Goiás, com delineamento de blocos inteiramente casualizados (DBC), composto por 6 tratamentos com 4 repetições. As observações foram feitas por meio de avaliações de folhas do terço inferior, médio e superior, comparando com as escalas diagramáticas. Ademais, foram analisadas a desfolha, incidência de doenças, produtividade e peso de mil grãos (PMG). Inicialmente obteve-se uma baixa pressão de mancha parda, porém ao final do ciclo a doença se intensificou juntamente com outra DFC, onde o tratamento 3 e 6 obtiveram melhores resultados. Já a ferrugem asiática, apresentou uma alta incidência, resultando em uma desfolha precoce nos tratamentos 1, 4 e 5, enquanto nos tratamentos 3, 2 e 6, foi observado um bom controle. O tratamento 3 teve produtividade similar ao T6, de forma que sobressaíram T2, sendo a produtividade deste similar ao T5. Portanto, a utilização de fungicida biológico associado ao químico demonstrou um melhor resultado, de forma que os biofungicidas podem ser uma importante ferramenta no manejo integrado das doenças foliares, que impactam na produtividade da cultura.
Peanut butter feeding induces oral tolerance in genetically diverse collaborative cross mice
Authors: Immormino Robert M. , Smeekens Johanna M. , Mathai Priscilla I. , Kesselring Janelle R. , Turner Andrew V. , Kulis Michael D. , Moran Timothy P. 
Published: July 2023

BackgroundEarly dietary introduction of peanut has shown efficacy in clinical trials and driven pediatric recommendations for early introduction of peanut to children with heightened allergy risk worldwide. Unfortunately, tolerance is not induced in every case, and a subset of patients are allergic prior to introduction. Here we assess peanut allergic sensitization and oral tolerance in genetically diverse mouse strains.ObjectiveWe aimed to determine whether environmental adjuvant-driven airway sensitization and oral tolerance to peanut could be induced in various genetically diverse mouse strains.MethodsC57BL/6J and 12 Collaborative Cross (CC) mouse strains were fed regular chow or ad libitum peanut butter to induce tolerance. Tolerance was tested by attempting to sensitize mice via intratracheal exposure to peanut and lipopolysaccharide (LPS), followed by intraperitoneal peanut challenge. Peanut-specific immunoglobulins and peanut-induced anaphylaxis were assessed.ResultsWithout oral peanut feeding, most CC strains (11/12) and C57BL/6J induced peanut-specific IgE and IgG1 following airway exposure to peanut and LPS. With oral peanut feeding none of the CC strains nor C57BL/6J mice became sensitized to peanut or experienced anaphylaxis following peanut challenge.ConclusionAllergic sensitization and oral tolerance to peanut can be achieved across a range of genetically diverse mice. Notably, the same strains that became allergic via airway sensitization were tolerized by feeding high doses of peanut butter before sensitization, suggesting that the order and route of peanut exposure are critical for determining the allergic fate.
Apolipoprotein E deficiency potentiates macrophage against Staphylococcus aureus in mice with osteomyelitis via regulating cholesterol metabolism
Authors: Lu Mincheng , He Ruiyi , Li Chao , Liu Zixian , Chen Yuhui , Yang Bingsheng , Zhang Xianrong , Yu Bin 
Published: July 2023

IntroductionStaphylococcus aureus (S. aureus) osteomyelitis causes a variety of metabolism disorders in microenvironment and cells. Defining the changes in cholesterol metabolism and identifying key factors involved in cholesterol metabolism disorders during S. aureus osteomyelitis is crucial to understanding the mechanisms of S. aureus osteomyelitis and is important in designing host-directed therapeutic strategies.MethodsIn this study, we conducted in vitro and in vivo experiments to define the effects of S. aureus osteomyelitis on cholesterol metabolism, as well as the role of Apolipoprotein E (ApoE) in regulating cholesterol metabolism by macrophages during S. aureus osteomyelitis.ResultsThe data from GSE166522 showed that cholesterol metabolism disorder was induced by S. aureus osteomyelitis. Loss of cholesterol from macrophage obtained from mice with S. aureus osteomyelitis was detected by liquid chromatography-tandem mass spectrometry(LC-MS/MS), which is consistent with Filipin III staining results. Changes in intracellular cholesterol content influenced bactericidal capacity of macrophage. Subsequently, it was proven by gene set enrichment analysis and qPCR, that ApoE played a key role in developing cholesterol metabolism disorder in S. aureus osteomyelitis. ApoE deficiency in macrophages resulted in increased resistance to S. aureus. ApoE-deficient mice manifested abated bone destruction and decreased bacteria load. Moreover, the combination of transcriptional analysis, qPCR, and killing assay showed that ApoE deficiency led to enhanced cholesterol biosynthesis in macrophage, ameliorating anti-infection ability.ConclusionWe identified a previously unrecognized role of ApoE in S. aureus osteomyelitis from the perspective of metabolic reprogramming. Hence, during treating S. aureus osteomyelitis, considering cholesterol metabolism as a potential therapeutic target presents a new research direction.
Comparing the therapeutic potentials of Lactobacillus johnsonii vs. Lactobacillus acidophilus against vulvovaginal candidiasis in female rats: an in vivo study
Authors: ElFeky Dalia Saad , Awad Alaa Reda , Shamseldeen Asmaa Mohammed , Mowafy Hagar Lotfy , Hosny Sara Adel 
Published: July 2023

BackgroundVulvovaginal candidiasis (VVC) is a highly prevalent illness affecting women globally. Lactobacilli, which make up the majority of healthy vaginal microbiota (VMB), serve as a powerful barrier against infections. Probiotic therapy has been recommended for the treatment or prevention of VVC.Aim of workTo compare the in vivo therapeutic effects of Lactobacillus johnsonii (B-2178) vs. Lactobacillus acidophilus (LA-5®) on VVC in a rat model, particularly highlighting the immune response of the host vaginal epithelium.MethodsIn total, 30 female Sprague-Dawley rats were divided into 5 groups; Group 1: no intervention, Group 2: ovariectomy group, while animals in Groups 3–5 were subjected to ovariectomy and an intravaginal inoculation of Candida albicans (C. albicans) to establish VVC. The animals in Groups 4 and 5 received intravaginal lactobacilli treatment with L. acidophilus (LA-5®) and L. johnsonii (B-2178) strains, respectively, for 7 days. C. albicans load was measured in a vaginal lavage 1, 3, and 7 days after the stoppage of the treatment. Histological, morphometric, and immunohistochemical studies of the vaginal tissues were done. IFN-γ, IL-4, and IL-17 were measured in the vaginal tissue.ResultsBoth L. johnsonii and L. acidophilus significantly reduced C. albicans vaginal load (250 ± 77.46 and 133.33 ± 40.82 CFU/mL) compared to the count before treatment in both groups (4,850 ± 1419.51 and 4966.67 ± 852.45 CFU/mL) even after 7 days of stoppage of lactobacilli treatment. A statistically significant reduction of the pro-inflammatory cytokines IL-17 and IFN-γ was reported in both treated groups compared to the infected untreated group. L. johnsonii has a significant effect on the reduction of hyphae formation of C. albicans as well as the nuclear factor kappa B (NF-κB) immunostaining density of vaginal tissue compared to L. acidophilus. Moreover, treatment with L. johnsonii significantly minimized the epithelium damage triggered by C. albicans infection and restored normal vaginal architecture as evidenced by the histologic and morphometric studies when compared to L. acidophilus.ConclusionThrough maintaining an immune tolerant state in the vaginal epithelium and ameliorating the undesirable uncontrolled inflammatory response in the vaginal tissue, L. johnsonii (B-2178) has the potential to be utilized alone or in combination with other lactobacilli species in probiotic clinical trials to treat or prevent VVC.
Effectiveness of different exercises in improving postural balance among Parkinson's disease patients: a systematic review and network meta-analysis
Authors: Wang Di , Cui Wen J. , Hou Zhen H. , Gao Ying 
Published: July 2023

BackgroundExercise has been reported as an effective intervention for Parkinson's disease. However, there is still debate on the what kinds of exercises prior to choosing. This study aimed to compare and rank the different exercises that effectively enhance postural balance in Parkinson's disease patients by quantifying the information gleaned from randomized controlled trials (RCTs).MethodsWe conducted a comprehensive database search, including PubMed, Cochrane Library, Embase, Web of Science, and PsycINFO. The included studies were evaluated for methodological quality by the Cochrane Risk of Bias tool.ResultsThe RCTs were collected between the earliest available date and March 2023. Sixty RCTs were included and the total sample size used in the study was 3,537. Thirty-five studies were defined as low risk of bias, twenty-one studies as medium risk of bias, and four studies as high risk of bias. The network meta-analysis results showed that exergaming exercise can significantly improve patients' Timed-Up-and-Go time (SUCRA = 91.5%). Dance can significantly enhance patients' Berg Balance Scale (surface under the cumulative ranking curve, SUCRA = 81.3%), and rhythmical auditory exercise can significantly improve patients' Mini-Balance Evaluation Systems Test score (SUCRA = 95.6%).ConclusionCompared with other exercises, exergaming exercise, Dance, and rhythmical auditory exercise showed superior efficacy in improving postural balance among Parkinson's disease patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023411918.
The normal reference values and estimation formulae of renal structural parameters in Chinese children based on large-sample CT data
Authors: Qin Yong , Liu En , Ni Xiaoying , Huang Zhongxin , Tian Lu , He Xiaoya , Cai Jinhua , Li Qiu 
Published: July 2023

PurposeOur aim was to investigate the normal reference value and to establish an estimation formulae for renal structural parameters (RSPs) based on large-sample CT data of Chinese children, which can provide a data reference for the clinical assessment of kidney development and diseases in Chinese children.Materials and MethodsA total of 438 children aged 0–17 years with normal renal CT images and basic indices were continuously collected. The bilateral RSP, including renal length (RL), renal width (RW), renal thickness (RT), renal volume (RV), renal cortical thickness (RCT), renal artery diameter (RAD) and renal CT value, were measured. Kendall's rank correlation was used to analyze the correlation between RSP and sex. Pearson's correlation was used to analyze the correlation between RSP and age, height and weight. Differences in the RSP of bilateral kidneys were analyzed via a paired samples t-test. Multiple linear regression was used to analyze the multivariate relationships between RSP and basic indices and establish the estimation formula of RSP.ResultsThe RSP of normal kidneys showed a dynamic increasing trend with age, except for the CT values. The reference value ranges (95% confidence interval) of normal RSP for each age group were determined. Pearson correlation analysis demonstrated strong correlations between RSP (RL, RW, RT, RV, RCT and, RAD) and basic indices (age, height and, weight), with height exhibiting the greatest correlation coefficient, followed by age or weight. Kendall's analysis showed that none of the RSPs were correlated with sex. The RL, RW, RV and RAD of the left kidney were larger than those of the right kidney, and the RT and RCT of the right kidney exhibited opposite results. Multiple linear regression analysis demonstrated a significant linear relationship between the RSP (RL, RW, RT, RV and, RCT) and the variables of the basic indices. The estimation formulae for calculating the RSP were established.ConclusionThis is the first Chinese study to report of the trends, normal reference values and estimation formulae of normal RSP based on large-sample CT data. These results can provide data references for assessing adequate kidney growth or disease damage in Chinese children.
Case report: Lung transplantation for treatment of paraquat intoxication: timing of transplantation
Authors: Li Congcong , Cai Hongfei , Meng Fanyu , Meng Fanjie , Tang Ze , Tang Ying , Chen Ying , Cui Youbin , Li Yang 
Published: July 2023

Objective: To analyze the optimal timing of lung transplantation and summarize postoperative complications and their management after paraquat poisoning.Methods: Here, we present the clinical course of a 17-year-old boy with paraquat poisoning, in whom bilateral lung transplantation (LT) was performed. We reviewed the eight previously published articles relevant to LT after paraquat poisoning to summarize the therapeutic strategy.Results: A 17-year-old boy was admitted to the hospital after ingestion of 30–50 mL 25% paraquat. Mechanical ventilation was initiated on the 25th day after intoxication. Venovenous extracorporeal membrane oxygenation was initiated on the 26th day. Sequential bilateral LT was performed on the 27th day. Several complex postoperative complications occurred and the patient was discharged on the 50th day postoperatively. Eight case reports were included in the literature review, including 11 patients with paraquat poisoning undergoing LT. Three patients died due to paraquat poisoning leading to fibrosis in the transplanted lungs or postoperative complications. Eight patients survived during follow-up.Conclusion: LT after herbicide poisoning should be planned when hepatorenal function starts to recover, and waiting for complete recovery is unnecessary. Prevention of infection before surgery is important to reduce the incidence of postoperative infection. Complex perioperative complications caused by the herbicide itself or the late timing of transplantation can be successfully managed by a multidisciplinary team.