bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social egg freezing: Motivations, treatment experiences and the impact of Covid‐19 – a single‐center experience
Authors: Murugesu Sughashini , Charalambides Mikaela Maria , Jones Benjamin P. , Saso Srdjan , Faris Raef , Parikh Jaya , Nicopoullos James , Thum Meen‐Yau , Bracewell‐Milnes Timothy 
Published: March 2023

AbstractIntroductionThis study aims to assess the motivations and treatment experiences of women undergoing social egg freezing and to understand the impact of the Covid‐19 pandemic.Material and methodsBetween January 2011 to December 2021, 191 social egg freezing patients were recruited from the Lister Fertility Clinic, London UK. Participants completed a validated questionnaire investigating patients’ perspectives of social egg freezing. A response rate of 46.6% was achieved.ResultsIn all, 93.9% of women expressed concern regarding age‐related fertility decline which influenced their decision to undergo social egg freezing. The majority (89.5%) of women were not in a relationship at the time of social egg freezing and considered this a motivating factor. Also, 39.0% of participants had side effects related to treatment which affected work and social life. Participants were significantly more likely to experience side effects if they underwent multiple egg freezing cycles (χ2, p < 0.01) or if they cryopreserved oocytes during the COVID‐19 pandemic (χ2, p < 0.05). Of the women, 64.0% wished to have cryopreserved oocytes at a younger age, a view significantly more likely if older than 37 years at first social egg freezing cycle (χ2, p < 0.001). Also, 82.3% of women reported their decision to undergo social egg freezing was not delayed due to concerns regarding COVID‐19 exposure during treatment; 44.1% considered the pandemic made them more willing to undergo social egg freezing.ConclusionsMost participants did not regret their decision to undergo social egg freezing but the majority wished they had cryopreserved oocytes at a younger age. This highlights the importance of early education to optimize outcomes and patient choice. The egg freezing process can be stressful, women may have concerns around social egg freezing and unprecedented situations such as the COVID‐19 pandemic may alter treatment experience.
Radial stem astrocytes (aka neural stem cells): Identity, development, physio‐pathology, and therapeutic potential
Authors: Yeh Chia‐Yu , Wu Kuan‐Yu , Huang Guo‐Jen , Verkhratsky Alexei 
Published: March 2023

AbstractAdult neurogenesis is a striking example of neuroplasticity, which enables adaptive network remodelling in response to all forms of environmental stimulation in physiological and pathological contexts. Dysregulation or cessation of adult neurogenesis contributes to neuropathology negatively affecting brain functions and hampering regeneration of the nervous tissue while targeting adult neurogenesis may provide the basis for potential therapeutic interventions. Neural stem cells in the adult mammalian brain are at the core and the entry point of adult neurogenesis. By their origin and properties, these cells belong to astroglia, and are represented by stem radial astrocytes (RSA) which exhibit multipotent “stemness”. In the neurogenic niches, RSA interact with other cellular components, including protoplasmic astrocytes, which in turn regulate their neurogenic activity. In pathology, RSA become reactive, which affects their neurogenic capabilities, whereas reactive parenchymal astrocytes up‐regulate stem cell hallmarks and are able to generate progeny that remain within astrocyte lineage. What makes RSA special is their multipotency, represented by self‐renewing capacity capability to generate other cellular types as progeny. A broad understanding of the cellular features of RSA and parenchymal astrocytes provides an insight into the machinery that promotes/suppresses adult neurogenesis, clarifying principles of network remodelling. In this review, we discuss the cellular hallmarks, research tools, and models of RSA and astrocytes of the subventricular zone along the lateral ventricle and dentate gyrus of the hippocampus. We also discuss RSA in ageing, which has a great impact on the proliferative capacity of RSA, as well as the potential of RSA and astrocytes in therapeutic strategies aimed at cell replacement and regeneration.
Comparison of carcass traits and nutritional profile in two different broiler‐type duck lines
Authors: Gao Wen , Cao Zhengfeng , Zhang Yu , Zhang Yang , Zhao Wenming , Chen Guohong , Li Bichun , Xu Qi 
Published: March 2023

AbstractCherry Valley ducks (CVDs) and White Kaiya ducks (WKDs) are judged to be fast‐ and slow‐growing lines, respectively. To investigate the carcass traits and nutritional profile at their marketable ages, 12 birds (38 days for CVDs, n = 6; 56 days for WKDs, n = 6) were randomly selected and slaughtered. Indicators such as breast muscle weight, shear force, and proximate composition were comprehensively detected. Although the carcass and breast muscle weight in WKDs were significantly lower, remarkably higher intramuscular fat and tenderness and less moisture content were observed in WKDs. Besides, WKDs contained higher contents of Cu, Zn, and Ca, whereas CVDs contained higher leucine (Leu) and histidine (His) compositions (P < 0.01). Moreover, higher monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) along with lower saturated fatty acids (SFAs) were detected in WKDs (P < 0.01). Taken together, despite light carcass and breast muscle weight, WKDs had advantages in nutritional compositions except for amino acid constituents, including intramuscular fat, MUFAs, and PUFAs, as well as Cu, Zn, and Ca. These data would not only provide genetic resources for breeding new duck lines but also offer a useful reference for making decisions on high‐nutrient meat consumption.
Economic bifurcations in pandemic leadership: Power in abundance or agency amid scarcity?
Authors: Uyheng Joshua , Montiel Cristina Jayme 
Published: March 2023

AbstractSocial psychological scholarship has emphasized the importance of effective leadership during the COVID‐19 pandemic. However, the wider material contexts of these dynamics have often remained understudied. Through a critical discursive lens, this paper investigates differences in the social constructions used by leaders of richer and poorer nations during the COVID‐19 pandemic. We identify a sharp economic bifurcation in global discourses of pandemic leadership. Pandemic leadership in wealthier nations exercises power in abundance by mobilizing institutions and inspiring communities through discursive frames of coordination and collaboration. Conversely, pandemic leadership in poorer settings negotiates agency amid scarcity by tactically balancing resources, freedoms and dignity within discursive frames of restriction and recuperation. Implications of these findings are unpacked for understanding leadership especially during an international crisis, highlighting the need for critical sensitivities to wider societal structures for a genuinely global social psychology.
COVID‐19 (Omicron strain) hospital admissions from a virtual ward – who required further care?
Authors: Mackay Ian , France Megan , McAuley Duncan , Wing Sean , Wheeldon Mary , Britton Susan , Todd Catherine , Pitiris Alexandra , Barrett‐Beck Leah , Rushbrook Elizabeth , Bennett Cameron , McCarthy Kate 
Published: March 2023

AbstractBackgroundThe COVID‐19 virtual ward was created to provide care for people at home with COVID‐19. Given this was a new model of care, little was known about the clinical characteristics and outcomes of patients requiring admission to hospital from the virtual ward platform.The aims were to characterise hospital admission volume, patient epidemiology, clinical characteristics, and outcome from a virtual ward in the setting of an Omicron (BA.1, BA.2) outbreak.MethodsA retrospective observational study was performed for all virtual ward patients admitted from 1st January 2022 to 25th March 2022 (over 16 years old). Epidemiological, clinical and laboratory data was reviewed on all patients who required hospital admission.ResultsA total of 7021 patients were cared for on the virtual ward over the study period with 473 referred to hospital for assessment. Twenty‐six (0.4%) patients were admitted to hospital during their care on the ward. Twenty‐two (84.6%) admissions were COVID‐19 related. Fifty three percent of the hospitalised patients were fully vaccinated and 11 had received prior therapeutics for COVID‐19. Shortness of breath was the most common reason for escalation to hospital. Chest pain was the second most common reason and the most common diagnosis after investigation was non‐cardiac chest pain.ConclusionsFew patients required admission from the virtual ward in the setting of the Omicron variant (BA.1, BA.2) as a direct result of COVID‐19 disease and virtual ward care. Shortness of breath and chest pain were the most common symptoms driving further clinical care.
Retention in nursing education and scholarship programs: Survival analysis of the Veterans Health Administration National Nursing Education Initiative Data
Authors: Toyinbo Peter , Rugs Deborah , Nedd Nicole , Wang Xinping , Hall Kimberly S. , Hyacinthe Martin , Cowan Linda 
Published: March 2023

AbstractAimsTo investigate factors affecting non‐completion by registered nurses (RNs) participating in degree programs supported by the scholarship program of the National Nursing Education Initiative of the United States Veterans Health Administration. Secondarily, to assess overall retention in the scholarship program over time.DesignRetrospective longitudinal design using administrative data.MethodsDefining retention time as the time elapsed from enrollment date to non‐completion, we performed survival (retention) analysis (i.e.,Kaplan–Meier survival functions, log‐rank tests and Cox regressions) to retrospectively analyzea national sample of RNs (N = 15,908) enrolled in the scholarship program between the United States federal fiscal years 2000 and 2020.ResultsNurses' mean age was 44 years (range: 19–71), and 86% were females. Six‐ and 12‐month cumulative educational program retention rates were 92% and 84% respectively. The newest group of enrollees (2016–2020), younger nurses (<50 years), and nurses in traditional degree programtype were more likely to complete their academic programs than the earlier groups, older nurses and nurses in non‐traditional type, respectively. Male nurses who aspired to advanced occupational levels upon completion were more likely to complete their academic programs compared to those who expected no change from their current level of practice.ConclusionMultiple factors affected non‐completion of academic degree programs by RNs enrolled in the scholarship program. More work is needed to examine these plus additional plausible factors and their correlates extensively.ImpactOur findings highlighted areas for quality improvement in employee scholarship programs for RNs. The findings are expected to inform tailoring of proactive helpful intervention towards individual needs and prioritization of limited resources to maximize graduation rate from academic programs for scholarship recipients. The study will have impact on nursing workforce policy makers interested in implementing employee scholarship programs, and on their scholarship recipients.
Online prelicensure nursing students' experiences of academic incivility during COVID‐19: A qualitative inquiry
Authors: Wilson Sharon T. , Urban Regina W. , Smith Jessica G. 
Published: March 2023

AbstractAimThe aim of this study was to describe online prelicensure nursing students' experiences of incivility during COVID‐19.DesignQualitative descriptive. Five optional open‐ended questions were presented to nursing students to share their experiences with incivility during the pandemic.MethodsData were collected from September to October 2020 as a part of a larger multimethod study on stress, resilience and incivility with nursing students and faculty (n = 710) from a large public undergraduate nursing programme in the southwestern United States. Out of the initial 675 students who completed the survey, 260 individuals responded to three or more of the open‐ended questions which were reviewed and coded using reflexive thematic analysis.ResultsThirteen themes were organized into four analytical categories: (1) experiencing incivility, (2) causes and consequences of incivility, (3) the pandemic and academic incivility and (4) promoting civility in the academic setting.ConclusionsPrelicensure nursing students perceived unrealistic expectations, a lack of awareness and miscommunication hindered academic performance, as well as, created feelings of stress, discouragement and inadequacy.Implications for the Profession and/or Patient CareFostering academic civility during virtual educational experiences may require training in proper coping strategies when challenged with incivility.ImpactAs the body of research emerges concerning the effects of COVID‐19 and undergraduate nursing education, understanding prelicensure students' experiences of academic incivility could prove to be beneficial to designing strategies co‐created with students to promote positive educational outcomes. Understanding students' viewpoints of uncivil experiences revealed prioritizing civility awareness is essential in creating healthy academic environments, improving clinical performance and providing safe patient care.Reporting MethodThe COREQ (COnsolidated criteria for REporting Qualitative research) checklist was used.Patient or Public ContributionNo patient or public contribution.
A range‐wide postglacial history of Swiss stone pine based on molecular markers and palaeoecological evidence
Authors: Gugerli Felix , Brodbeck Sabine , Lendvay Bertalan , Dauphin Benjamin , Bagnoli Francesca , van der Knaap Willem O. , Tinner Willy , Höhn Maria , Vendramin Giovanni G. , Morales‐Molino César , Schwörer Christoph 
Published: March 2023

AbstractAimKnowing a species' response to historical climate shifts helps understanding its perspectives under global warming. We infer the hitherto unresolved postglacial history of Pinus cembra. Using independent evidence from genetic structure and demographic inference of extant populations, and from palaeoecological findings, we derive putative refugia and re‐colonisation routes.LocationEuropean Alps and Carpathians.Taxa
Pinus cembra.
MethodsWe genotyped nuclear and chloroplast microsatellite markers in nearly 3000 individuals from 147 locations across the entire natural range of P. cembra. Spatial genetic structure (Bayesian modelling) and demographic history (approximate Bayesian computation) were combined with palaeobotanical records (pollen, macrofossils) to infer putative refugial areas during the Last Glacial Maximum (LGM) and re‐colonisation of the current range.ResultsWe found distinct spatial genetic structure, despite low genetic differentiation even between the two disjunct mountain ranges. Nuclear markers revealed five genetic clusters aligned East–West across the range, while chloroplast haplotype distribution suggested nine clusters. Spatially congruent separation at both marker types highlighted two main genetic lineages in the East and West of the range. Demographic inference supported early separation of these lineages dating back to a previous interstadial or interglacial c. 210,000 years ago. Differentiation into five biologically meaningful genetic clusters likely established during postglacial re‐colonisation.Main ConclusionsCombining genetic and palaeoecological evidence suggests that P. cembra primarily survived the LGM in ‘cold period’ refugia south of the Central European Alps and near the Carpathians, from where it expanded during the Late Glacial into its current Holocene ‘warm period’ refugia. This colonisation history has led to the distinct East–West structure of five genetic clusters. The two main genetic lineages likely derived from ancient divergence during an interglacial or interstadial. The respective contact zone (Brenner line) matches a main biogeographical break in the European Alps also found in herbaceous alpine plant species.
Barrier function‐related genes and proteins have an altered expression in acne‐involved skin
Authors: Dull Katalin , Lénárt Kinga , Dajnoki Zsolt , Póliska Szilárd , Uchiyama Eri , Hendrik Zoltán , Szegedi Andrea , Törőcsik Dániel 
Published: March 2023

AbstractBackgroundAcne vulgaris provides a unique disease setting in which a prominent skin inflammation is coupled with the overproduction of lipid‐rich sebum.ObjectivesOur goal was to evaluate the expression of barrier molecules in papular acne skin samples obtained from untreated patients and compare those to the results of healthy and of papulopustular rosacea‐involved ones at the mRNA and protein levels. In addition, we aimed to assess the effects of various sebum composing lipids on the expression of proteins involved in barrier formation in keratinocytes.MethodsAvailable microarray data sets of papular acne and papulopustular rosacea‐affected skin samples were re‐analysed with a focus on epidermal barrier‐related pathways. Immunohistochemistry was performed to detect barrier molecules in the interfollicular regions of human acne and healthy skin samples. Protein levels of barrier‐related genes were measured by western blot in samples of HaCaT keratinocytes treated with selected lipids.ResultsMeta‐analysis of whole transcriptome data sets revealed that barrier‐related pathways are significantly affected in acne vulgaris skin samples. While an altered expression of key molecules in maintaining barrier functions such as filaggrin, keratin 1, involucrin, desmoglein 1, kallikrein 5 and 7, was also observed at the protein levels, our data demonstrated that sebum composing lipids may selectively modify the levels of epidermal barrier‐related molecules.ConclusionsOur results suggest that although not as prominently as in the dry papulopustular rosacea skin, the epidermal barrier in the interfollicular region may be damaged also in the lipid‐rich skin samples of papular acne. Furthermore, our findings indicating diverse regulatory effects of various sebum lipids on the expression of barrier molecules in keratinocytes suggest, that they may influence the moisturization of the skin as well. Altogether, our findings could have implications in the development of sebum‐modulating anti‐acne therapies and even in the care of symptom‐free skin.
Institutional investors' corporate site visits and aggressive financial reporting
Authors: Cui Xin , Liao Jing , Wang Lu 
Published: March 2023

AbstractThis paper investigates the impact of institutional investors' corporate site visits on financial reporting aggressiveness. While prior research has shed light on the monitoring impact of institutional shareholding on firms' financial reporting practices, institutional investors' preference regarding financial reporting remains unclear. Using a sample of Chinese firms listed on the Shenzhen Stock Exchange from 2012 to 2019, we find that institutional investors' on‐site visits significantly increase financial reporting aggressiveness of hosting firms. The on‐site visit effect is more salient in firms that are more sensitive to the influence of institutional investors, for example, firms with a less powerful chief executive officer, financially constrained firms, and firms operating in competitive industries. Our study highlights that under a setting of weak minority shareholder protection such as in China, managers are likely to recognize revenue aggressively to please powerful shareholders who paid intensive attention to them.
Competitive Effects of IPOs: Evidence from Chinese Listing Suspensions
Authors: PACKER FRANK , SPIEGEL MARK M. 
Published: March 2023

AbstractTheory suggests that initial public offerings (IPOs) can adversely impact listed firms, both directly by increasing intraindustry competition, and indirectly by completing related asset market spaces. However, the endogeneity of individual IPO activity hinders testing these channels. This paper examines listing suspensions in China in a panel specification that accounts for macro‐economic and financial conditions, isolating the firm‐level IPO impact. We identify the competitive impact of listing suspensions through the value share of postponed firms in the IPO queue in their industry, and asset‐space competition by firms' historical covariance with a synthetic portfolio of listed firms with the IPO queue industry mix at the time of suspension. Our results support the predicted IPO effects through both channels. We also document heterogeneity in IPO effects. Stronger firms, measured through a variety of proxies, benefit less from the suspension news. These results are robust to a battery of sensitivity tests.
Measurement properties of quality‐of‐life outcome measures for children and adults with eczema: A systematic review update 2.0
Authors: Gabes Michaela , Donhauser Theresa , Piontek Katharina , Kann Gesina , Fechtner Marie , Gulde Isabell , Knüttel Helge , Apfelbacher Christian ,   for the quality of life working group of the Harmonising Outcome Measures for Eczema (HOME) initiative
Published: March 2023

AbstractA systematic review on measurement properties of patient‐reported outcome measures (PROMs) for the assessment of quality of life (QoL) in children and adults with eczema was published in 2016 and updated in 2019. We now aimed to systematically assess the measurement properties of PROMs based on recently published development and validation studies regarding quality‐of‐life skin‐ or disease‐specific PROMs using the COnsensus‐based Standards for the selection of health Measurement Instruments (COSMIN) guidelines and integrate these findings with those from the 2019 update. A systematic literature search was conducted in PubMed and Embase. Eligible studies reported on measurement properties of QoL skin‐ or disease‐specific PROMs for the assessment of QoL in children and adults with eczema. The methodological quality of the included studies was evaluated using the COSMIN Risk of Bias checklist. The methodological quality of the included PROMs was judged using updated criteria for good measurement properties, and the quality of evidence was graded. The new evidence was integrated into the results from the 2019 update. Finally, a recommendation for use of the identified PROMs was derived based on all evidence. We identified 12 studies fulfilling our inclusion criteria. Based on the newly generated evidence, the Childhood Atopic Dermatitis Impact Scale—short form (CADIS‐SF) for infants and the Skindex for adults can be recommended for use. We identified three new PROMs, which have the potential to be used, but require further validation: the Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ), the Skindex‐Mini, and the Scratch Intensity and Impact Scale (SIIS). All other assessed PROMs still have the opportunity to be recommended for use (except for the Dermatology Life Quality Index (DLQI)) but need further validation. Currently, two PROMs for the assessment of QoL in eczema can be recommended for use: the CADIS‐SF for infants and the Skindex for adults. Many PROMs, including the recently developed and/or validated PROMs PADQLQ, Skindex‐Mini and SIIS, need further validation.