bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends and projections of inflammatory bowel disease at the global and national levels, 1990–2050: A bayesian age-period-cohort modeling study
Authors: Zhou Jia-Li , Bao Jia-Chen , Liao Xu-Ying , Chen Yi-Jia , Wang Lin-Wei , Fan Yan-Yun , Xu Qin-Yu , Hao Lan-Xiang , Li Kun-Jian , Liang Ming-Xian , Hu Tian-Hui , Liu Zheng-Jin , Hu Yi-Qun 
Published: September 2023

Abstract
Background: Inflammatory bowel disease (IBD) is a global health concern with varying levels and trends across countries and regions. Understanding these differences is crucial for effective prevention and treatment strategies.
Methods: Using data from the 2019 Global Burden of Disease study, we examine IBD incidence, mortality, and disability-adjusted life years (DALYs) rates in 198 countries from 1990 to 2019. By analyzing estimated annual percentage change (EAPC) and employing a Bayesian model, we predict IBD trends over 50 years.
Results:In 2019, there were 404,552 new IBD cases globally (95% uncertainty interval (UI) 360,521.17 to 456,478.46), with 40,998 deaths (95% UI 34,932.99 to 44,660.80) and 1,622,498.43 DALYs (95% UI 1,356,295.86 to 1,915,042.45). The global age-standardized incidence rate in 2019 was 4.97 per 100,000 person-years (95% UI 4.43 to 5.59), with a mortality rate of 0.54 (95% UI 0.46 to 0.59) and DALYs rate of 20.15 (95% UI 16.86 to 23.71). From 1990 to 2019, EAPC values for incidence, mortality, and DALYs rates were -0.60 (95% UI -0.73 to -0.48), -0.69 (95% UI -0.81 to -0.57), and -1.04 (95% UI -1.06 to -1.01), respectively. Predictions using a Bayesian model showed lower new cases and deaths from 2020 to 2050 than reference values, with similar incidence-time curves.
Conclusion: Increasing cases, deaths, and DALYs highlight the sustained burden of IBD on public health. Developed countries have stabilized or declining incidence rates but face high prevalence and societal burden. Emerging and developing countries experience rising incidence. Understanding these changes aids policymakers in effectively addressing IBD challenges in different regions and economic contexts.
Attitudes and perceptions of mothers with pregestational diabetes toward breastfeeding
Authors: Schiller Tal , Gassner Tali , Shafran Yael Winter , Schiller Ofer , Zornitzki Taiba , Kirzhner Alena 
Published: September 2023

Abstract
Background
Current data on breastfeeding perceptions and attitudes in women with pregestational diabetes mellitus (PGDM) is limited. The aim of the current study was to evaluate perceptions and attitudes towards breastfeeding before birth in women with PGDM versus women without diabetes and to evaluate whether targeted counseling at the end of pregnancy in the diabetic population affected women’s perceptions regarding breastfeeding.
Methods
Fifty-two women with PGDM and 38 women without diabetes answered a structured questionnaire designed to evaluate attitudes and perceptions toward breastfeeding. We also explored whether structured instruction, given to diabetic women towards the end of pregnancy, by an experienced breastfeeding counselor changed these perceptions. The purpose of the instruction was twofold; to elucidate practical aspects and strategies to overcome challenges of breastfeeding alongside diabetes, and to review realistic breastfeeding expectations for the early postpartum period.
Results
Diabetic and non-diabetic women had shared concerns regarding the complexity of breastfeeding, and insufficient knowledge. However, diabetic women expressed more concerns overall. The main motivation to breastfeed among diabetic women was the health benefits for their newborn. End-of-pregnancy targeted instruction improved confidence in breastfeeding knowledge and confidence in being able to manage blood glucose. It also improved confidence in approaching healthcare professional when seeking help.
Conclusion
A targeted diabetes-oriented breastfeeding instruction session at the end of pregnancy improved knowledge and confidence among diabetic women. It also improved their confidence in medical staff. Further investigation to find the optimal combination of education and support is still needed.
Biostimulation of Indigenous Microbes for Uranium Bioremediation in Former U Mine Water: Multidisciplinary approach assessment.
Authors: Newman-Portela Antonio M , Krawczyk-Bärsch Evelyn , Lopez-Fernandez Margarita , Bok Frank , Kassahun Andrea , Drobot Björn , Steudtner Robin , Stumpf Thorsten , Raff Johannes , Merroun Mohamed L. 
Published: September 2023

Abstract

Characterising physicochemistry and microbial diversity in uranium (U) mine water is a key prerequisite for understanding the biogeochemical processes occurring in these water mass and for the design of an efficient bioremediation strategy. In this study water samples from two former U-mines in East Germany were analysed. The U and sulphate (SO42−) concentrations of Schlema-Alberoda mine water (U: 1 mg/L; SO42−: 335 mg/L) are 2 and 3 order of magnitude higher than those of the Pöhla sample (U: 0.01 mg/L; SO42−: 0.5 mg/L). U, SO42− and Fe seem to shape the differential microbial diversity of the two water samples. Microbial diversity analysis identified U(VI)-reducing bacteria (e.g., Desulfurivibrio) and wood-degrading fungi (e.g., Cadophora) providing electron donors for the growth of U-reducers. U-bioreduction experiments were performed to screen electron donors (glycerol, vanillic acid and gluconic acid) for Schlema-Alberoda U mine water bioremediation. Glycerol effectively removed 99% of soluble U (initially present as Ca2UO2(CO3)3(aq) and UO2(CO3)34−), along with 95% of Fe and 58% of SO42− from the mine water. The results may contribute to the design of low U concentrations bioremediation strategies based on the biostimulation of U-reducing bacteria.
Ultrasonography as a way of evaluating the diaphragm muscle in patients with chronic obstructive pulmonary disease.
Authors: Silva Bianca Carmo Figueira , de Abreu Diego Condesso , de Souza Yves Raphael , Figueiredo Manoele , Macêdo Joseane Felix , Mafort Thiago Thomaz , Rufino Rogério , Costa Cláudia Henrique da 
Published: September 2023

Abstract

Background:
Diaphragmatic mobility (DM) may be reduced in chronic obstructive pulmonary disease (COPD) patients, but little is known about whether this mobility correlates with functional parameters, exercise capacity, and indicators of disease severity.
Objective:
To evaluate the DM of COPD patients and relate the findings with the distance achieved in the six-minute walk test (6MWT), forced expiratory volume in one second (FEV1) % of predicted, residual volume (RV) % of predicted, and dyspnea.
Methods:
An observational cohort study was conducted to analyze DM through ultrasound during breathing, at rest and during deep inspiration and expiration.
Results:
It was included 49 COPD stable patients. There was a correlation between the DM measured between expiration and maximum inspiration with FEV1% of predicted (r = 0.36; p = 0.012), RV % of predicted (r = -0.42; p = 0.01), RV/Total Lung Capacity (TLC) (r = -0.61; p < 0.001), and distance reached in the 6MWT (r = 0.46; p = 0.001). In addition, patients with MRCm <2 had a greater DM than those with a score >2 (mean difference 13.20 + 4.6 mm; p = 0.0059), and patients with a BODE index <4 presented greater mobility (61.95 mm) than patients with a BODE index >4 (47.89 mm) (mean difference 14.05 + 5.3 mm; 95% CI 25.09 to 3.01 mm).
Conclusion:
The results obtained suggest that DM is related to bronchial obstruction (FEV1), lung hyperinflation (RV and RV/TLC), exercise capacity, and the measurement of dyspnea, suggesting that it is an option for evaluating COPD patients.
Reutilization of brewer's spent grain as spent mushroom substrate for the generation of biogas in a semi-continuous digester
Authors: Ganuza Mauricio Roque , Mejia Santiago Jaramillo , Albertó Edgardo 
Published: September 2023

Abstract
In this work we explore the use of brewers' spent grain (BSG) to produce biogas after it was used to produce the edible mushroom Pleurotus pulmonarius within the concept of circular economy. We compare the production of biomethane obtained using: i) spent mushroom substrate (SMS) and ii) BSG to feed the digester. We produced the mushroom using a mixture of sawdust and BSG and the resulting SMS was used to feed the digester. The mono-digestion of both substrates was carried out in 19l semi-continuos biodigesters (SB), in mesophilic conditions (35°C), constant stirring of 200 rpm and a hydraulic retention time of 30 days. The start-up of SB was carried out in stages. PH, volume and biogas composition were recorded daily. Accumulated biogas volumes of 59.971 l and 465.73 l were obtained for the SMS and BSG respectively. The average methane composition was 42% for SMS and 55% for BSG. The methane yield obtained was 35.95 and 265.495 l CH4/KgVS for SMS and BSG, respectively. The use of BSG, first as substrate for mushroom production, and then, using SMS to produce biogas would not be a recommended practice if the main objective were the production of biogas. Since it is much more efficient to produce biomethane when BSG is used directly. The results obtained from the use of BSG show that this substrate improves the yield of mushroom production and can be used for the production of biogas in SB with a high performance.
A Prospective Observational study on Acute Respiratory Failure In Pregnancy And Puerperium.
Authors: Ghotra Maninder Kaur , Singh Anju , Suri Vanita , Prasad KT , Jain Kajal , Panda Prashant , . Tulika , Saini Shivsajan 
Published: September 2023

Abstract
Purpose
To elucidate the etiological spectrum of acute respiratory failure in pregnant and postpartum patients and its impact on feto maternal outcomes were studied.
Methods
This was a hospital- based prospective observational study, conducted over 18 months. All pregnant women with acute onset respiratory distress which fit into the inclusion criteria formed the study population. Detailed evaluation was carried out. Maternal and fetal outcomes were noted.
Results
Incidence of acute respiratory failure (ARF) 0.6%, 50 patients with ARF were identified among 8660 pregnant patients requiring hospitalization for any reason, out of which 58% (n = 29) were postpartum. Among antepartum and postpartum subjects, preeclampsia (38%) and puerperal sepsis (21%) were the commonest causes of ARF, respectively. Our study population had maternal mortality and perinatal mortality of 34% and 42%, respectively. Postpartum subjects with ARF had more severe disease (P = 0.040) and higher mortality( P = 0.016).
Conclusion
The leading causes of ARF during antenatal and postpartum period are preeclampsia and puerperal sepsis, respectively. ARF during pregnancy is associated with a high maternal and perinatal mortality rate.
Benefits and limitations of ChatGPT in basic care: Influence on the diagnosis and treatment of neuromyelitis optic
Authors: de Souza Alessandra Hubner , Santiago Juliana , Alvarenga Julia , Felicíssimo Fernanda De Luca , Dias Quézia , Dantas Fernando Luiz 
Published: September 2023

Abstract
Introduction: Artificial intelligence (AI) has developed rapidly, and it has been used in medical practice. The Chat Generative Pre-Trained Transformer (ChatGPT) is a recently released open access AI model that interacts with user inputs in a conversational manner. The objective of this work is to analyze the veracity of the information provided by the software and compare the responses generated with the current medical literature. Methods: Several questions about neuromyelitis optica spectrum disorders (NMOSD) were sent to ChatGPT on June 19, 2023. We analyzed the veracity of the information provided by it and we analyzed its possible limitations in the dissemination of information to both physicians and patients. Results: The answers provided by ChatGPT demonstrated that the information is compatible with the current literature on the topic. With regard to diseases, unlike other websites, ChatGPT proved to be responsible in providing information, clarifying that, as an AI software, it is not capable of providing accurate medical diagnoses; It therefore recommends consultation with a health professional. ChatGPT responses are only as good as the data they are trained on. Conclusions: ChatGPT was responsible for accurate responses and can now offer patients the ability to select and categorize the results of these queries, as well as pre-specify the language complexity of the output text. We can only speculate about the next steps in the exponential growth of this technology, and how it will transform future care for neuromyelitis optica spectrum disorders.
Clinical feasibility of endovascular recanalization with intravascular ultrasound-guided for chronic total occlusion of below-the-knee arteries
Authors: Hayakawa Naoki , Kodera Satoshi , Miwa Hiromi , Ichihara Shinya , Hirano Satoshi , Arakawa Masataka , Inoguchi Yasunori , Kushida Shunichi 
Published: September 2023

Abstract
Background
Revascularization with endovascular therapy (EVT) for complex below-the-knee (BTK) chronic total occlusion (CTO) remains a challenging problem. The Japanese-BTK (J-BTK) CTO score is reported as an indicator of the difficulty of BTK CTO, with the guidewire (GW) passage success rate decreasing as the grade increases. We previously reported an effective GW crossing method for the intravascular ultrasound (IVUS)-guided parallel wiring of complex BTK CTO. In this study, we investigated the feasibility of EVT using IVUS-guided wiring for BTK CTO. The primary endpoint was the clinical success of the target CTO vessel. The secondary endpoints were the GW success rate per grade based on the J-BTK CTO score, number of GW used for CTO crossing, fluoroscopy time, and complications.
Results
This single center, retrospective study analyzed 65 consecutive BTK CTO vessels in which IVUS-guided wiring was attempted after the failure of a conventional antegrade wiring approach from November 2020 to November 2022. Target vessels were the anterior tibial artery (66.2% of cases), peroneal artery (9.2%), and posterior tibial artery (24.6%). Blunt type CTO entry was performed in 55.4% of cases, calcification of entry was observed in 24.6% of cases, the occlusion length was 228.2 ± 93.7mm, reference vessel diameter was 2.1 ± 0.71 mm, and outflow was absent in 38.5% of cases. J-BTK CTO scores of 0/1 (grade A), 2/3 (grade B), 4/5 (grade C), and 6 (grade D) were seen in 18.5%, 43.1%, 36.3%, and 1.5% of cases, respectively. The clinical success rate was 95.4%. The GW success rate by J-BTK CTO grade was as follows: grade A (100%), B (100%), C (91.7%), and D (0%). The number of GW used was 3.4 ± 1.4, the fluoroscopy time was 72.3 ± 32.5 min, and complications occurred in 7.7% of cases.
Conclusion
This study showed a very high clinical success rate despite the difficulty of BTK CTO. IVUS-guided EVT might be a feasible strategy for complex BTK CTO.
Demographic history shapes North American gray wolf genomic diversity and informs species’ conservation
Authors: vonHoldt Bridgett , Stahler Daniel , Brzeski Kristin , Musiani Marco , Peterson Rolf , Phillips Michael , Stephenson John , Laudon Kent , Meredith Erin , Vucetich John , Leonard Jennifer , Wayne Robert 
Published: September 2023

Abstract
Effective population size estimates are critical information needed for evolutionary predictions and conservation decisions. This is particularly true for species with social factors that restrict access to breeding or experience repeated fluctuations in population size across generations. Further, if isolated, the only natural process that introduces new variation into the gene pool is de novo mutation rate. We investigated the genomic estimates of effective population size along with diversity, subdivision, and inbreeding from 81,595 RADseq SNPs genotyped in 437 gray wolf samples from North America collected between 1986 and 2021. We found genetic structure across North America, represented by three distinct demographic histories of western, central, and eastern regions of the continent. Further, gray wolves in the northern Rocky Mountains have lower genomic diversity than wolves of the western Great Lakes and has declined over time. Effective population size estimates revealed the historical signatures of continental efforts of predator extermination, despite a quarter century of recovery efforts. We are the first to provide molecular estimates of effective population size across distinct gray wolf populations in North America, which ranged between Ne~141–226 since 1990. We provide data that informs managers regarding the status and importance of effective population size estimates for gray wolf conservation, which are on average 5.2–9.3% of census estimates for this species. We show that while gray wolves fall above minimum effective population sizes needed to avoid extinction due to inbreeding depression in the short term, they are below sizes predicted to avoid long-term risk of extinction.
Efficient removal of methylene blue and tetracycline hydrochloride with C60 /MIL-101(Fe) as a reusable photocatalyst under visible light
Authors: Zhou Zhuyou , Zou Congyang , Wang Yong , Liu Menghe , Ji Yufeng 
Published: September 2023

Abstract
In this work, the C60/MIL-101(Fe) composites were prepared by a one-step solvothermal synthesis method. The fabricated C60/MIL-101(Fe) composites exhibited higher activities than MIL-101(Fe) in degradation of methylene blue (MB) and tetracycline hydrochloride (TCH) in photo-Fenton system, which was due to the charge transfer and separation promoted by the introduction of C60. The results indicated that C60/MIL-101(Fe) was capable of almost complete removal of TCH and MB with a wide pH range. The catalysts also exhibited excellent catalytic degradation on different organic pollutants and water samples. Finally, active substance quenching experiments and electron spin resonance (EPR) revealed that hydroxyl radical (•OH) plays a dominant role in photocatalytic reaction process.
Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability During Simulated Ankle Sprain
Authors: Zhang Gonghao , Cao Shengxuan , Zha Chaochao , Zhang Guoning , Zhang Yangyang , Xiong Li , Huang Ping , Wang Chen , Zhang Chao , Ma Xin , Ji Yunhan 
Published: September 2023

Abstract
Background
Ankle braces can effectively decrease the incidence of recurrent ankle sprain; however, whether the brace can decrease the severity of sprain and its related mechanism during sprain remain unknown.
Methods
22 patients with functional ankle instability (FAI) (12 males and 10 females) and 16 healthy subjects (8 males and 8 females) were enrlled in this study. All of the subjects walked on a custom-built tilting platform that offered a 30° inversion to mimic the inversion of ankle sprain. We collected the kinematic and sEMG data of patients with FAI with or without ankle brace and normal controls six times.
Results
The FAI without brace group showed significantly higher maximum inversion angles and average inversion velocities than the control group (P < 0.001). The FAI with brace group revealed significantly lower maximum inversion angles and average inversion velocities than the FAI without brace group (P < 0.001); this group also showed significantly higher maximum external rotation angle and average external rotation velocities than the FAI with brace (P < 0.001) and control (P < 0.001) groups. The FAI with brace group indicated significantly lower average EMGPrep (P = 0.047), EMGTilt (P = 0.037), and EMGafterTilt (P = 0.004) of the peroneus longus (PL) than the FAI without brace group.
Conclusions
The ankle brace could effectively decrease inversion angles and their velocities and increase external rotation angles and their corresponding velocities during ankle sprain in patients with FAI. It could also decrease the activity of the PL muscle during ankle sprain.
Regional and cellular iron deposition patterns predict clinical subtypes of multiple system atrophy
Authors: Lee Seojin , Martinez-Valbuena Ivan , Lang Anthony E. , Kovacs Gabor G. 
Published: September 2023

Abstract
Background
Multiple system atrophy (MSA) is a primary oligodendroglial synucleinopathy, characterized by elevated iron burden in early-affected subcortical nuclei. Although neurotoxic effects of brain iron deposition and its reciprocal relationship with α-synuclein pathology have been demonstrated, the exact role of iron dysregulation in MSA pathogenesis is unknown. In this regard, advancing the understanding of iron dysregulation at the cellular level is critical, especially in relation to α-synuclein cytopathology.
Methods
We performed the first cell type (α-synuclein-affected and -unaffected neurons, astroglia, oligodendrocytes, and microglia)-specific evaluation of MSA iron deposition in the globus pallidus (GP), putamen, and the substantia nigra (SN), using a combination of iron staining with immunolabelling on human post-mortem MSA brains. We evaluated selective regional and cellular vulnerability patterns to iron deposition distinctly in MSA-parkinsonian (MSA-P) and cerebellar (MSA-C) subtypes and explored possible underlying molecular pathways by mRNA expression analysis of key iron- and the closely related oxygen-homeostatic genes.
Results
MSA-P and MSA-C showed a distinct pattern of regional iron burden across the subcortical nuclei. We identified microglia as the major cell type accumulating iron in these regions of MSA brains, which was more distinct in MSA-P. MSA-C showed a more heterogenous cellular iron accumulation, in which astroglia showed greater or similar accumulation of iron. Notably, iron deposition was found outside the cellular bodies in the same regions and cellular iron burden minimally correlated with α-synuclein cytopathology. Gene expression analysis revealed dysregulation of oxygen, rather than of cellular iron, homeostatic genes. Importantly, hierarchal cluster analysis revealed pattern of cellular vulnerability to iron accumulation, rather than of α-synuclein pathology load in the subtype-related systems, to distinguish MSA subtypes.
Conclusions
We identified distinct regional, and for the first time, cellular distribution of subcortical iron deposition in MSA-P and MSA-C, and revealed cellular vulnerability pattern to iron deposition as a novel neuropathological characteristic that predicts MSA subtypes, distinctly from α-synuclein pathology. These findings support the role of iron dysregulation as an early effector of disease pathology in MSA. Our findings suggesting distinct iron-related pathomechanisms in MSA subtypes inform current efforts in iron chelation therapies at the disease and cellular-specific levels.