bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boosting the light-harvesting and surface properties of inorganic ceramic to tune its bactericidal and organic dye mineralization activities
Authors: Aadil Muhammad , Hassan Warda , Mubarik Shamroza , zainab Breeha , Maqbool Uzma , Alsalmah Hessa A. , Ejaz Syeda 
Published: August 2023

Abstract
This work presented a simple co-precipitation technique for forming nanostructured, porous, visible light-active, highly conductive, and Zn-doped copper oxide (ZCO). The combine effects of doping, structural modification, and nanoscience enable to form a novel catalyst with integrated features. Physicochemical studies confirm the coexistence of all desired features in the ZCO photocatalyst. Dye-mineralization and antimicrobial capabilities of the formed photocatalysts were evaluated in detail and compared with those of their undoped counterpart, copper oxide (CO). The antimicrobial activities of the ZCO photocatalyst, tested against E. coli (a negative strain) and S. aureus (a negative strain), were superior to those of CO and comparable to those of commercially available drugs. Furthermore, ZCO photocatalysts eliminate the methyl blue dye using simple adsorption and mineralization processes at a greater extent and rate than CO photocatalyst. More precisely, the ZCO photocatalyst mineralizes 80.61% of MB under visible light irradiation. Under identical circumstances, the CO photocatalyst mineralizes just 60.10% of MB. The amplified photoactivity of the ZCO photocatalyst may be endorsed to its larger surface area (56.5 m2g− 1) and visible-light prompted bandgap (1.59 eV), which not only enhance the dye adsorption probability but also improved the light-harvesting capabilities. This study opens new avenues for developing metal-substituted metal oxide porous nanostructures for environmental and ecological protection.
Sociodemographic and Decision-Making Factors Associated with Unmet Family Planning Needs among Married Women in Madi Municipality, Chitwan, Nepal
Authors: Ghimire Rochana , Shah Rajani , Baral Yojana , Malla Dinesh Kumar , Thapa Kanchan 
Published: August 2023

Abstract

Background
Sustainable Development Goal of Nepal targets universal access to family planning (FP) services and increasing the contraceptive prevalence rate to 75% by 2030. Despite continuous efforts from the government of Nepal in the FP sector, the prevalence of unmet need for FP is high. This study aimed to identify sociodemographic and decision-making factors associated with the unmet need for FP among married women of reproductive age.
Methods
This is a community-based cross-sectional study conducted in Madi municipality, Chitwan, Nepal. Face-to-face interviews were conducted with 218 married women of reproductive age using a semi-structured questionnaire. Descriptive statistics, chi-square tests and multivariate logistic regression were used to analyse the data.
Results
The overall unmet need for FP was 38%. Respondents whose husbands were involved in foreign employment were more likely [aOR: 4.408; CI: 2.068–9.399] to have an unmet need for FP than those employed within the country. The likelihood of the unmet need was higher [aOR: 3.212; CI: 1.368–8.135] among couples who did not discuss using FP methods compared to those who discussed three or more times. Women with up to two children [aOR: 5.212; CI: 1.163–23.363] and three or more children [aOR: 8.758; CI: 1.691–45.355] were more likely to have a higher unmet need for FP than women without a child.
Conclusion
A significant proportion of women had an unmet need for FP. Intervention should focus on addressing the FP needs of migrants and their spouses, promoting spousal discussion on FP and counselling on the treatment as well as side effects of contraceptives. Furthermore, empowering women would enable them in the decision-making process and in accessing FP services.
Nucleotide supplementation as a novel adjunctive therapy for canine atopic dermatitis
Authors: Barroso Carolina D. N. , Cavalheiro Vitória L. , Imamura Louise M. , Cordeiro Caroline C. , Ingberman Max , Caron Luiz Felipe , Beirão Breno C. B. 
Published: August 2023

Abstract
Atopic dermatitis (AD) is an important allergic condition in dogs, and treatment is lifelong. Alternatives for therapy are important, as dogs do not respond equally to commonly used therapies. Novel therapies on the market are also costly, which limits their adoption in low and middle-income countries. Nucleotides have been shown to improve innate barrier function and were therefore tested for their efficacy in canine atopic dermatitis. Two independent mouse trials were performed. The first trial (pilot) aimed to standardize the atopic dermatitis challenge model and to perform a proof-of-concept for the use of nucleotides for the treatment of AD. The second trial expanded on the results of the first by assessing the oral use of the experimental compound. Lastly, a clinical trial was run on 27 dogs with naturally occurring AD, for 8 weeks. The mouse trials revealed that use of nucleotides diminished the dermal inflammation that is common in AD. On histopathological analyses, scores of inflammatory cells, and fibrosis in the dermis of were lower in treated mice, resulting in diminished dermal thickness. Both oral and injectable administration routes proved effective. Differently from what occurred in the dermis, epidermal thickening was not reversed by the test compound. In dogs, oral treatment reduced owner-assessed pruritus and in vet-assessed erythema. These data indicate a possible use for oral nucleotide supplementation against canine AD.
Awareness of strabismus and associated factors among adults in Jimma town, Southwest Ethiopia
Authors: Daba¹ Kumale Tolossa , * Segni Tesfaye Aga² , Regassa³ Tolossa Tufa 
Published: August 2023

Abstract
Background: Strabismus is a common problem that mostly affects children. Awareness of eye diseases is important in encouraging people to seek early treatment, which further helps in reducing the burden of visual impairment. The aim of this study was to assess awareness of strabismus and associated factors among adults in Jimma town, Southwest Ethiopia.
Methods: A community-based cross-sectional study was conducted on adults in Jimma Town using a pretested structured questionnaire from June 1 to June 30, 2022. A sample size of 631 was determined by using a single proportion formula and taking an awareness of strabismus of 52.3% from the most recent local study, a 95% confidence interval, a 5% margin of error, a nonresponse rate of 10%, and a design effect of 1.5.
Binary logistic regression was used to identify factors associated with awareness of strabismus. A multivariable logistic regression model was performed, and a p value <0.05 was considered to indicate statistical significance.
Results:A total of 584 individuals were interviewed with a response rate of 92.5%.
A total of 43.7% of the participants were found to have a good level of awareness of strabismus.
In addition, a statistically significant association was found between the level of awareness of strabismus and age, previous eye examination, and level of education. The most common source of information was the community.
Conclusions: The study found that a significant proportion of the participants had poor awareness of strabismus, particularly regarding its causes and treatment options. Thus, it is better if awareness creation is facilitated by the responsible bodies for the community.
PARP1 is differentially expressed in BCR-ABL p190+ ALL patient samples and targeting PARP inhibition induces cell death comparable to that of tyrosine- kinase golden standard in pre-clinical models
Authors: Machado Caio Bezerra , Silva Emerson Lucena da , Ferreira Wallax Augusto Silva , Pessoa Flávia Melo Cunha de Pinho , de Quadros Andreza Urba , Fantacini Daianne Maciely Carvalho , Furtado Izadora Peter , Rossetti Rafaela , Silveira Roberta Maraninchi , de Lima Sarah Caroline Gomes , Júnior Fernando Augusto Rodrigues Mello , Seabra Aline Damasceno , Moreira Edith Cibelle de Oliveira , Filho Manoel Odorico de Moraes , de Moraes Maria Elisabete Amaral , Montenegro Raquel Carvalho , Ribeiro Rodrigo Monteiro , Khayat André Salim , Burbano Rommel Mário Rodriguez , Oliveira Edivaldo Herculano Correa , Covas Dimas Tadeu , de Souza Lucas Eduardo Botelho , Moreira-Nunes Caroline Aquino 
Published: August 2023

Abstract
Detection of t(9;22), and consequent BCR-ABL1 fusion, is still a marker of worse prognosis for acute lymphoblastic leukemia (ALL), with resistance to tyrosine-kinase inhibitor therapy being a major obstacle in the clinical practice for this subset of patients. In this study, we investigated the effectiveness of targeting poly-ADP-ribose polymerase (PARP) in a model of BCR-ABL p190 + ALL, the most common isoform to afflict ALL patients, and demonstrated the use of experimental PARP inhibitor (PARPi), AZD2461, as a therapeutic option with cytotoxic capabilities similar to that of imatinib, the current golden-standard in medical care. We characterized cytostatic profiles, induced cell death and biomarker expression modulation utilizing cell models, also providing a comprehensive genome-wide analysis through aCGH of the model used, and further validated PARP1 differential expression in samples of ALL p190 + patients from local healthcare institutions, as well as in larger cohorts of online and readily available datasets. Overall, we hope our findings help expand the characterization of molecular profiles in ALL settings and guide future investigations into novel biomarker detection and pharmacological choices in the clinical practice.
Visualization of photothermal therapy by semiconducting polymer dots mediated photoacoustic detection in NIR II
Authors: Lin Xiangwei , Xu Zhourui , Li Jiangao , Shi Hongji , Fu Zhenyu , Chen Yuqing , Lin Haoming , Xu Gaixia , Chen Xin , Chen Siping , Chen Mian 
Published: August 2023

Abstract
Visualization of photothermal therapy mediated by photothermal transduction agents (PTAs) is important to promote individual treatment of patients with low side effect. Photoacoustic detection has emerged as a promising noninvasive method for the visualization of PTAs distribution, but has still limitations in temperature measurement, including poor measurement accuracy and low tissue penetration depth. In this study, we have developed biocompatible semiconducting polymer dots (SPD) for in situ coupling of photothermal and photoacoustic detection in the near-infrared II window. The SPD has dual-photostability under the irradiation of pulsed laser and continuous-wave laser with 42.77% of photothermal conversion efficiency. Meanwhile, a strong correlation between the photoacoustic signal and the actual temperature of SPD can be observed. The standard deviation of SPD-mediated photoacoustic thermometry can reach to 0.13°C when the penetration depth of gelatin phantom is 9.49 mm. Preliminary experimental results in vivo show that SPD mediated photoacoustic signal has a high signal-to-noise ratio, as well as good performance in temperature response and tumor enrichment. Such a study not only offers a new nanomaterial for the visualization of photothermal therapy, but will also promote the theranostic platform for clinical applications.
Postprandial Hypotension Is More Common Than Orthostatic Hypotension In Older Adults With Dementia With Lewy Bodies: A Cross-Sectional Study
Authors: ISIK Ahmet Turan , ONTAN MEHMET SELMAN , DOST Fatma Sena , MUTLAY Feyza , MAHSER Alev CAM , YILDIRIM ACELYA GOKDENIZ , KAYA Derya 
Published: August 2023

Abstract
Purpose
Dysautonomia is one of the supportive clinical features in dementia with Lewy bodies (DLB). This study aimed to investigate the prevalence of postural and postprandial blood pressure changes as a sign of dysautonomia in DLB patients.
Methods
The study group comprised 125 patients with DLB (76 females; mean age 78.4 ± 7.1 years) and 126 controls (89 females; mean age 74.5 ± 6.8 years). Postprandial blood pressure changes were assessed by ambulatory 24-hour blood pressure monitorization. Postural blood pressure changes were assessed via the head-up tilt table test.
Results
The frequency of postprandial hypotension (PPH), orthostatic hypotension (OH), and delayed OH was higher in patients with DLB compared to controls (89.4% vs 50.8%; p < 0.001, 45.5% vs 28.6%; p = 0.006, and 13.3% vs 5.6%; p = 0.045, respectively); whereas the frequency of supine hypertension (HT), and orthostatic hypertension (OHT) was similar. However, supine HT in non-hypertensive participants was higher in DLB patients than in controls (n = 45, 48.9% vs n = 37, 27%; p = 0.043). PPH and OH were independently associated with DLB (odds ratio [OR]:10.52 confidence interval [CI]%95 3.11–35.61; p < 0.00, and OR:1.96 CI%95 1.05–3.69; p = 0.035, respectively) after adjustment for age, the number of drugs, anti-psychotics, antiparkinsonian drugs, angiotensin receptor blockers, and beta blockers.
Conclusion
The study demonstrated that PPH was the most common type of dysautonomia, followed by OH and supine HT in older patients with DLB Given the potential complications of postural blood pressure changes and PPH in such patients, autonomic dysfunction should be evaluated in the follow-up of DLB.
Splice-altering variant in TECTA as a cause of hearing loss DFNA8/12
Authors: Yang Yan , Luo Haiyan , Feng Chuanxin , Zou Yongyi , Guo Zhen , Zeng Baitao , Huang Shuhui , Yuan Huizhen , Ma Pengpeng , Wu Ping , Liu Danping , Lu Qing , Luo Laipeng , Xiao Junfang , Jiang XiangLong , Yang Bicheng , Liu Yuhe , Liu Yanqiu 
Published: August 2023

Abstract
Purpose
The aim of this study was to determine the genetic cause of early onset autosomal dominant hearing loss segregating in five-generation kindred of Chinese descent and provide preimplantation genetic testing for them.
Methods
Clinical examination, pedigree analysis, exome sequencing, minigene-based splicing analysis and in vivo RNA analysis were carried out on the family. Preimplantation genetic testing (PGT) for the causative variation and chromosome aneuploidis based on SNP analysis has been used to avoid transmission of hearing loss in this family.
Results
All the affected individuals presented with moderate down-sloping hearing loss and whole-exome sequencing identified a novel splice-site variant c.5383 + 6T > A in the tested subjects within the TECTA locus. Genotyping of all the 32 family members confirmed segregation of this variant and the deafness phenotype in the extended family. Functional analysis of RNA indicated that c.5383 + 6T > A is a pathogenic splice-site variant and should be considered for diagnostic purposes. Furthermore, a successful singleton pregnancy with no variant in the site c.5383 + 6 within TECTA locus was established and a healthy male child was born by PGT.
Conclusion
We have identified a novel variant c.5383 + 6T > A in TECTA ZA-ZP inter-domain, which could be contributing to in early onset autosomal dominant hearing loss phenotype,The implications of our study are valuable in the clinical diagnosis, prognosis, and treatment of patients with TECTA pathogenic variants.
Association Between Depression and Osteoporosis of the United States population: a cross-sectional study
Authors: Zheng Yanxu , Bao Jing , Li Kecheng , Zhang Xin , Guo Jingchen , Guo Weiqin , He Jinshen 
Published: August 2023

Abstract
Depression and osteoporosis both are common mental illness for older people and the relationship between osteoporosis and depression is still unclear. This article aims to determine the relationship between depression and osteoporosis among adults aged 50 or older. The study, which included 6153 participants, consisting of the control group (n = 5726) and the osteoporosis group (n = 432), was based on the National Health and Nutrition Examination Survey (NHANES) database. Compared with individuals who do not have osteoporosis, those who have osteoporosis have a higher incidence of depression (10.7% vs 6.6%, P = 0.002). Individuals with depression are more likely to also have osteoporosis (OR: 1.60, 95% CI: 1.12 to 2.29, P = 0.010). On subgroup analysis, there were higher odds ratio of osteoporosis in male (OR: 2.47, 95% CI: 1.21 to 5.05, P = 0.013), individuals between the ages of 50 to 65 are at a greater risk (OR: 2.16, 95% CI: 1.25 to 3.74, P = 0.006), high BMI (OR: 1.67, 95% CI: 1.06 to 2.64, P = 0.027), taking prednisone or cortisone(OR: 2.92, 95% CI: 1.06 to 8.05, P = 0.039), and patients with high cholesterol levels (OR: 2.14, 95% CI: 1.36 to 3.35, P = 0.001). Therefore, doctors should pay attention to the osteoporosis middle-aged and elderly people with depression.
Cerebral mechanism of Tuina on the descending pain inhibitory system in knee pain Study protocol for a randomized controlled parallel trial
Authors: Xu Hui , Wang Zheng , Wang Zhen , Zhou Hang , Chen Xiaojing , Guo Juan , Li Wanyu , Xie Yuchen , Zhou Yunfeng 
Published: August 2023

Abstract

Background:Tuina, a manual therapy, is effective and safe for reducing clinical symptoms of knee osteoarthritis (KOA); however, the mechanism that influences pain through the descending pain inhibitory system in KOA is unclear. Thus, we will investigate the modulatory implications of Tuina on the rostral ventromedial medulla (RVM) and periaqueductal gray (PAG), which have critical roles in the descending pain inhibitory system in patients with KOA.Methods:This is a randomized, controlled parallel trial. Patients with KOA will be randomly assigned (1:1) to 6 weeks of health education or Tuina. Functional and structural magnetic resonance imaging, pressure pain thresholds, numerical rating scale, Hamilton Anxiety Scale, Western Ontario and McMaster Universities Osteoarthritis Index, and Hamilton Depression Scale will be conducted at the beginning and end of the experiment. We will use PAG and RVM as seeds in resting-state functional connectivity (rsFC) analysis. Adverse events will be documented and assessed throughout. The outcome evaluators and data statisticians will be blinded to the treatment group assignment to reduce the risk of bias.Discussion:Our trial will provide evidence on the effect of Tuina on rsFC in patients with KOA and identify possible relationships between rsFC changes and improvement of clinical variables, elucidating the effect of Tuina on the descending pain inhibitory system of patients with KOA.Trial registration: Chinese Clinical Trial Registry (ChiCTR2300070289). Date of registration: April 7, 2023
Rational design of star-shaped triarylborane-based thermally activated delayed fluorescent emitters for organic light-emitting diodes
Authors: Jin Ruifa , Xin Jingfan , Xiao Wenmin 
Published: August 2023

Abstract
A series of novel donor (D)–acceptor (A) star-shaped triarylborane-based molecules have been designed for the applications in organic light-emitting diodes (OLEDs) devices with thermally activated delayed fluorescence (TADF) properties. Their photophysical and electronic properties have been systematically investigated by applying density functional theory (DFT) and time dependent DFT (TD-DFT) methods. The frontier molecular orbitals (FMOs) analysis has turned out that the vertical electronic transitions exhibit a strong charge transfer character. The D and A fragments are separated efficiently. Furthermore, all the designed molecules display small singlet-triplet energy gap (ΔEST) values, which is beneficial for TADF properties. Our results suggest that the introduction of different donors can tune the delayed fluorescence emission colour effectively. The designed molecules are expected to be the promising candidates TADF materials for organic light-emitting diodes (OLEDs).
Analysis and interpretation IT in supply chain management practices of manufacturing industries IN Tehran
Authors: AghaiGhalechi Mohsen , Souri Maryam , Poursobhan Fatemeh 
Published: August 2023

Abstract
This study aims to evaluate how well manufacturing industries in Tehran province are adopting IT-enabled tools for supply chain management, as well as how successful these technologies are at reducing costs and managing customer relationships. Small, medium, and big registered manufacturing enterprises have been used as the population for this purpose, and surveys with the production department have been undertaken. The study's focus is only on Tehran's manufacturing sectors. For the purposes of the study, the total population has been determined as the number of manufacturing companies registered with the Tehranian administration. In Tehran province, there are currently 3532 small-scale manufacturing businesses, 54 medium-scale manufacturing facilities, and 37 large-scale manufacturing facilities. The population for the present study was determined using the information on registered industrial units in Tehran that was made available by the Department of Industry and Commerce in the Tehran government and the Tehran Province Industrial Development Corporation. Future scholars and practitioners of SCM in the manufacturing sector will find the study beneficial in understanding the significance of IT-enabled tools and how efficiency may be attained in the supply chain operations of the manufacturing sector.
Quantifying the spin-orbit effect in molecular clusters using Steradians and Spin-Orbit geometries
Authors: Morales-Bayuelo Alejandro 
Published: August 2023

Abstract
The manuscript discusses the concepts of spin-orbit coupling in atomic physics and Molecular Quantum Similarity (MQS) in molecular clusters. Spin-orbit coupling arises from the interaction between an electron's spin and its motion around the nucleus and plays a crucial role in determining energy levels and spectral lines in atoms with heavy nuclei. On the other hand, MQS is a computational approach to compare the electronic density distributions in different molecular systems. In this order of ideas, the study aims to answer questions about electronic and structural differences caused by the spin-orbit effect from the standard geometry (Steradians geometry) using the MQS framework. The MQS is based on the Molecular Quantum Similarity Measure (MQSM) using different positive operators such as Dirac delta and Coulomb operators to quantify the similarity between molecular systems. The paper presents tables with MQSM indices and Euclidean distances for different molecular clusters using both spin-orbit (SO) and standard geometry (SR). The results show significant effects of spin-orbit coupling on the similarity measures between different molecules. The manuscript suggests that understanding the relationship between spin-orbit effects and quantum similarity could lead to deeper insights into electronic interactions in complex molecular systems and has potential applications in quantum mechanics and molecular physics.
Political Epidemiology of Covid-19 Mortality: A Multilevel Analysis of Macro-Systemic Political Variables
Authors: nguyen Thuy 
Published: August 2023

Abstract
This study delves into the realm of "political epidemiology" which has gained increasing attention among scholars of political science and public health. It investigates how Covid mortality rate are influenced by macro-systemic political variables such as the level of democracy, systems of internal governance, government effectiveness, and trust in government. Employing multilevel modeling, I analyze countries' trajectories of Covid-19 mortality rates spanning from March 2020 to January 2022. I found that, on average, countries with a federal system tend to exhibit higher Covid-19 death rates compared to those with a unitary system. Moreover, democracy is found to be inversely associated with Covid-19 mortality across countries, although the specific effects of democracy on the trajectory of Covid-19 rates depend on the subgroup of countries considered. Furthermore, government effectiveness emerges as a crucial factor, with a negative association with Covid-19 mortality rates. Countries with more effective governance tend to experience lower death tolls from Covid-19. Additionally, in countries where the population demonstrates higher levels of trust in the government, the curves of Covid-19 death tolls tend to flatten.