bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proximal gastrectomy and double-tract reconstruction vs total gastrectomy in gastric and gastro-esophageal junction cancer patients — a systematic review and meta-analysis protocol (PROSPERO registration number: CRD42021291500)
Authors: Hipp Julian , Kuvendjiska Jasmina , Martini Verena , Hillebrecht Hans Christian , Fichtner-Feigl Stefan , Diener Markus K. 
Published: August 2023

Abstract
Background
In Germany and Western Europe, gastroesophageal junction cancer (AEG) and proximal gastric cancer are currently treated with (transhiatal-extended) total gastrectomy (TG) according to the latest treatment guidelines. TG leads to a severe and long-lasting impairment of postoperative health-related quality of life (HRQoL) of the treated patients. Recent studies have suggested that HRQoL of these patients could be improved by proximal gastrectomy with double-tract reconstruction (PG-DTR) without compromising oncologic safety. Our aim is therefore to conduct a randomized controlled non-inferiority trial comparing PG-DTR with TG in AEG II/III and gastric cancer patients with overall survival as primary endpoint and HRQoL as key secondary endpoint.

Methods
This protocol is written with reference to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P 2015) statement. We will conduct searches in the electronic databases MEDLINE, Web of Science Core Collection, ScienceDirect, and Cochrane Library. We will also check references of relevant studies and perform a cited reference research. Titles and abstracts of the records identified by the searches will be screened, and full texts of all potentially relevant articles will be obtained. We will consider randomized trials and non-randomized studies. The selection of studies, data extraction, and assessment of risk of bias of the included studies will be conducted independently by two reviewers. Meta-analysis will be performed using RevMan 5.4 (Review Manager (RevMan) Version 5.4, The Cochrane Collaboration).

Discussion
This systematic review will identify the current study pool concerning the comparison of TG and PG-DTR and help to finally refine the research questions and to allow an evidence-based trial design of the planned multicenter randomized-controlled trial.

Ethics and dissemination
Ethical approval is not required for this systematic review. Study findings will be shared by publication in a peer-reviewed journal.

Systematic review registration
PROSPERO CRD42021291500.
Patient and public involvement to inform priorities and practice for research using existing healthcare data for children’s and young people’s cancers
Authors: Hughes Nicola F. , Fern Lorna A. , Polanco Angela , Carrigan Chris , Feltbower Richard G. , Gamble Ashley , Connearn Emily , Lopez Angela , Bisci Ellen , Pritchard-Jones Kathy 
Published: August 2023

Abstract
Background
In the United Kingdom, healthcare data is collected on all patients receiving National Health Service (NHS) care, including children and young people (CYP) with cancer. This data is used to inform service delivery, and with special permissions used for research. The use of routinely collected health data in research is an advancing field with huge potential benefit, particularly in CYP with cancer where case numbers are small and the impact across the life course can be significant.
Patient and public involvement (PPI) exercise aims:

Identify current barriers to trust relating to the use of healthcare data for research.

Determine ways to increase public and patient confidence in the use of healthcare data in research.

Define areas of research importance to CYP and their carers using healthcare data.

Methods
Young people currently aged between 16 and 25 years who had a cancer diagnosis before the age of 20 years and carers of a young person with cancer were invited to take part via social media and existing networks of service users. Data was collected during two interactive online workshops totalling 5 h and comprising of presentations from health data experts, case-studies and group discussions. With participant consent the workshops were recorded, transcribed verbatim and analysed using thematic analysis.

Results
Ten young people and six carers attended workshop one. Four young people and four carers returned for workshop two. Lack of awareness of how data is used, and negative media reporting were seen as the main causes of mistrust. Better communication and education on how data is used were felt to be important to improving public confidence. Participants want the ability to have control over their own data use. Late effects, social and education outcomes and research on rare tumours were described as key research priorities for data use.

Conclusions
In order to improve public and patient trust in our use of data for research, we need to improve communication about how data is used and the benefits that arise.
Evaluating the impacts of patient engagement on a national health research network: results of a case study of the Chronic Pain Network
Authors: Tripp Laura , Richards Dawn P. , Daly-Cyr Jennifer , Lane Therese , Linkiewich Delane , Begley Kimberly N. , Buckley Norman , Hudspith Maria , Poulin Patricia , Abelson Julia 
Published: August 2023

Abstract
Background
The Chronic Pain Network (CPN) is a pan-Canadian research network focused on innovating and improving the quality and delivery of pain prevention, assessment, management and research for all Canadians. An important focus of the CPN is to work in collaboration with patient partners. Patient partners, researchers and clinicians work together in all aspects of the research network including on funded research projects and in the governance of the Network. Given this focus, the CPN identified the importance of evaluating their patient engagement work to understand its functioning and impact.

Methods
The objective of this exploratory evaluation case study was to understand the impacts of patient engagement on the CPN. The CPN worked with an external evaluation team which established an arms-length approach to the evaluation. Interviews were conducted with CPN members, including patient partners, leadership, funded researchers and committee co-chairs, at three discrete time points to trace the evolution of the patient engagement program within the Network. Key Network documents were also collected and reviewed. Data were analyzed following each set of interviews using content analysis guided by the principles of constant comparison and qualitative description. A final round of analysis was conducted using the Engage with Impact Toolkit, an impact measurement framework, to identify impacts of engagement.

Results
Impacts of patient engagement were identified at the individual, network, funded research project and research community levels. These impacts were observed in the following areas: (1) building community; (2) developing knowledge, skills and resources; (3) increasing confidence; (4) influencing priorities and decisions; (5) enabling additional opportunities; (6) promoting culture change; and, (7) coping with experiences of living with chronic pain.

Conclusions
While not without challenges, the patient engagement efforts of the CPN demonstrates the impact engaging patient partners can have on a national research network and related policy activities. Understanding the approaches to, and impacts of, patient engagement on health research networks can illuminate the value of having patient partners engaged in all aspects of a research network and should serve as encouragement to others who look to take on similar work.
Less is more: information needs, information wants, and what makes causal models useful
Authors: Kleinberg Samantha , Marsh Jessecae K. 
Published: August 2023

AbstractEach day people make decisions about complex topics such as health and personal finances. Causal models of these domains have been created to aid decisions, but the resulting models are often complex and it is not known whether people can use them successfully. We investigate the trade-off between simplicity and complexity in decision making, testing diagrams tailored to target choices (Experiments 1 and 2), and with relevant causal paths highlighted (Experiment 3), finding that simplicity or directing attention to simple causal paths leads to better decisions. We test the boundaries of this effect (Experiment 4), finding that including a small amount of information beyond that related to the target answer has a detrimental effect. Finally, we examine whether people know what information they need (Experiment 5). We find that simple, targeted, information still leads to the best decisions, while participants who believe they do not need information or seek out the most complex information performed worse.
Participatory logic modeling in a multi-site initiative to advance implementation science
Authors: Easterling Douglas V. , Jacob Rebekah R. , Brownson Ross C. , Haire-Joshu Debra , Gundersen Daniel A. , Angier Heather , DeVoe Jennifer E. , Likumahuwa-Ackman Sonja , Vu Thuy , Glasgow Russell E. , Schnoll Robert 
Published: August 2023

Abstract
Background
Logic models map the short-term and long-term outcomes that are expected to occur with a program, and thus are an essential tool for evaluation. Funding agencies, especially in the United States (US), have encouraged the use of logic models among their grantees. They also use logic models to clarify expectations for their own funding initiatives. It is increasingly recognized that logic models should be developed through a participatory approach which allows input from those who carry out the program being evaluated. While there are many positive examples of participatory logic modeling, funders have generally not engaged grantees in developing the logic model associated with their own initiatives. This article describes an instance where a US funder of a multi-site initiative fully engaged the funded organizations in developing the initiative logic model. The focus of the case study is Implementation Science Centers in Cancer Control (ISC3), a multi-year initiative funded by the National Cancer Institute.

Methods
The reflective case study was collectively constructed by representatives of the seven centers funded under ISC3. Members of the Cross-Center Evaluation (CCE) Work Group jointly articulated the process through which the logic model was developed and refined. Individual Work Group members contributed descriptions of how their respective centers reviewed and used the logic model. Cross-cutting themes and lessons emerged through CCE Work Group meetings and the writing process.

Results
The initial logic model for ISC3 changed in significant ways as a result of the input of the funded groups. Authentic participation in the development of the logic model led to strong buy-in among the centers, as evidenced by their utilization. The centers shifted both their evaluation design and their programmatic strategy to better accommodate the expectations reflected in the initiative logic model.

Conclusions
The ISC3 case study demonstrates how participatory logic modeling can be mutually beneficial to funders, grantees and evaluators of multi-site initiatives. Funded groups have important insights about what is feasible and what will be required to achieve the initiative’s stated objectives. They can also help identify the contextual factors that either inhibit or facilitate success, which can then be incorporated into both the logic model and the evaluation design. In addition, when grantees co-develop the logic model, they have a better understanding and appreciation of the funder’s expectations and thus are better positioned to meet those expectations.
GMA: Gap Imputing Algorithm for time series missing values
Authors: Khattab Abd Alhamid Rabia , Elshennawy Nada Mohamed , Fahmy Mahmoud 
Published: August 2023

AbstractData collected from the environment in computer engineering may include missing values due to various factors, such as lost readings from sensors caused by communication errors or power outages. Missing data can result in inaccurate analysis or even false alarms. It is therefore essential to identify missing values and correct them as accurately as possible to ensure the integrity of the analysis and the effectiveness of any decision-making based on the data. This paper presents a new approach, the Gap Imputing Algorithm (GMA), for imputing missing values in time series data. The Gap Imputing Algorithm (GMA) identifies sequences of missing values and determines the periodic time of the time series. Then, it searches for the most similar subsequence from historical data. Unlike previous work, GMA supports any type of time series and is resilient to consecutively missing values with different gaps distances. The experimental findings, which were based on both real-world and benchmark datasets, demonstrate that the GMA framework proposed in this study outperforms other methods in terms of accuracy. Specifically, our proposed method achieves an accuracy score that is 5 to 20% higher than that of other methods. Furthermore, the GMA framework is well suited to handling missing gaps with larger distances, and it produces more accurate imputations, particularly for datasets with strong periodic patterns.
Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature
Authors: Khan Hameed Haidar , Ullah Imran , Rufaq Javeria , Wadood Qaiser , Majeed Imad , Khan Salman 
Published: August 2023

Abstract
Background
Celiac disease, an autoimmune condition triggered by gluten-containing diet, is known to primarily manifest as intestinal symptoms, but can also lead to extraintestinal complications, including endocrine abnormalities and autoimmune disorders. This case report outlines a patient with celiac disease who developed hypopituitarism and explores the possible pathophysiological links between these two conditions.

Case presentation
We report a case of a 19-year-old female who presented with lethargy, weakness, delayed menarche, and failure to thrive. Subsequent investigations revealed microcytic anemia with decreased serum ferritin and vitamin D levels. Following the identification of abnormal bone age on X-ray, a hormonal profile was requested which revealed panhypopituitarism. After undergoing a diagnostic workup for her gastrointestinal symptoms, she was eventually diagnosed with celiac disease, and her symptoms improved significantly following gluten restriction.

Conclusion
Panhypopituitarism has a possible association with celiac disease, and this case highlights the importance of close monitoring and appropriate management to prevent long-term health consequences. Additional research is necessary to gain a comprehensive understanding of the link between celiac disease and endocrine disorders.
Distribution of CO2-CH4 in a nanoslit medium and the efficiency of displacement of CH4 by CO2
Authors: Xu Jingling , Chen Gaoyang , Guo Songwei 
Published: August 2023

The replacement of CH4 with CO2 in reservoirs is crucial for natural gas exploitation and sequestration of CO2. Therefore, the states and distribution patterns of coexisting CO2 and CH4 and the dynamic patterns of CH4 displacement by CO2 in mineral slits must be understood. Here, we simulate the molecular dynamics and displacement efficiency of CH4 in gypsum, quartz, and illite mineral slit models. The results demonstrate that gas density is not uniform throughout the slits and prove that gypsum and quartz have a greater adsorption capacity for CO2 than for CH4 and illite has a greater adsorption capacity for CH4. We find that (1) the application of the same force to different mineral slits leads to dissimilar CH4 displacement efficiencies, whereas an increase in the applied force in the same mineral slit is positively correlated with the CH4 displacement efficiency; (2) the main factor affecting CH4 displacement efficiency is CO2 adsorption; (3) the greater the adsorption capacity of mineral slits for CO2 (such as for gypsum), the more difficult it is to displace the CH4 in the slit despite large applied force; and (4) CH4 displacement efficiencies of illite, quartz, and gypsum decrease under the same conditions. These results provide a reference for theoretical research and industrial applications related to geologic carbon sequestration.
Training matters: neurodevelopmental disorders in psychiatric practice
Authors: Barrett Mary , Sharma Aastha , Gnanavel Sundar , van Hoorn Alje 
Published: August 2023

SUMMARYTraditionally, service provision for neurodevelopmental disorders such as attention-deficit hyperactivity disorder, intellectual disability and autism – where this has been available – has focused on the needs of children, but there is now increased understanding of neurodevelopmental disorders as lifelong conditions, often with an ongoing need for health and social care provision. Medical and allied professionals frequently report limited education in neurodevelopmental disorders both during their training and post-qualification. This article gives an overview of theoretical and practical considerations for training of psychiatrists and allied healthcare professionals in relation to neurodevelopmental disorders. Key UK policy drivers and capability frameworks pertaining to this training are discussed. The Royal College of Psychiatrists’ 2022 revised curricula for medical trainees in psychiatry are examined in relation to neurodevelopmental disorders and ongoing CPD requirements in this area for career psychiatrists are considered. A brief overview of multidisciplinary training in neurodevelopmental disorders and the role of the psychiatrist in this is discussed. An international perspective on training in this area is touched on and current challenges in low- and middle-income countries are outlined. Last, the future direction of training in neurodevelopmental disorders is considered.
New guidance for self-harm: an opportunity not to be missed
Authors: Mughal Faraz , Burton Fiona M. , Fletcher Harriet , Lascelles Karen , O'Connor Rory C. , Rae Sarah , Thomson Alex B. , Kapur Nav 
Published: August 2023

SummaryIn this editorial we, as members of the 2022 NICE Guideline Committee, highlight and discuss what, in our view, are the key guideline recommendations (generated through evidence synthesis and consensus) for mental health professionals when caring for people after self-harm, and we consider some of the implementation challenges.
A Psychosis Superspectrum in Borderline Personality Disorder?
Authors: Henriques-Calado J. , Paulino M. , Gama Marques J. 
Published: August 2023

Introduction
The innermost relationship of the borderline concept and psychosis has been historically intertwined and can be traced back to the 20th century, but remarkably, to date, they have not been the focus of many empirical studies. Likewise, the contributions of empirical research on the DSM-5 dimensional approach to this topic are also uncommon.

Objectives
In this study the framework of psychosis superspectrum were put closely in relation to both DSM-5 psychoticism/detachment domains, personality traits and psychopathological symptoms features in borderline personality disorder (PD).

Methods
A cross-sectional study of a borderline PD sample of 58 participants (Mage=39.76 years, SD=11.37; Mschooling=9 years), mainly male (58.5%). Self-reported assessment: PID-5; BSI; NEO-FFI. A multiple linear regression was computed.

Results
In borderline PD, the PID-5 disinhibition (β=.51), BSI psychoticism (β=.43), BSI depression (β=-.24) and NEO neuroticism (β=.29) predicted psychosis superspectrum, explaining 94% of the variance. Also, stands out as a complement that, the BSI psychoticism was predicted by PID-5 detachment and PID-5 psychoticism, explaining 82% of the variance.

Conclusions
Evidence appears to be emerging for the underlying psychosis superspectrum trough borderline PD. There is a closer dialogue between the state-of-art view of a dimensional pathological personality-symptoms and the borderline pathology.

Disclosure of Interest
None Declared
Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain
Authors: Leino Sami A. , Constable Sean C. J. , Streit Andrea , Wilkinson David G. 
Published: August 2023

ABSTRACT
Developing tissues are sequentially patterned by extracellular signals that are turned on and off at specific times. In the zebrafish hindbrain, fibroblast growth factor (Fgf) signalling has different roles at different developmental stages: in the early hindbrain, transient Fgf3 and Fgf8 signalling from rhombomere 4 is required for correct segmentation, whereas later, neuronal Fgf20 expression confines neurogenesis to specific spatial domains within each rhombomere. How the switch between these two signalling regimes is coordinated is not known. We present evidence that the Zbtb16 transcription factor is required for this transition to happen in an orderly fashion. Zbtb16 expression is high in the early anterior hindbrain, then gradually upregulated posteriorly and confined to neural progenitors. In mutants lacking functional Zbtb16, fgf3 expression fails to be downregulated and persists until a late stage, resulting in excess and more widespread Fgf signalling during neurogenesis. Accordingly, the spatial pattern of neurogenesis is disrupted in Zbtb16 mutants. Our results reveal how the distinct stage-specific roles of Fgf signalling are coordinated in the zebrafish hindbrain.
The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila
Authors: Frasch Manfred , Ismat Afshan , Reim Ingolf , Raufer Jasmin 
Published: August 2023

ABSTRACT
Development of the visceral musculature of the Drosophila midgut encompasses a closely coordinated sequence of migration events of cells from the trunk and caudal visceral mesoderm that underlies the formation of the stereotypic orthogonal pattern of circular and longitudinal midgut muscles. Our study focuses on the last step of migration and morphogenesis of longitudinal visceral muscle precursors and shows that these multinucleated precursors utilize dynamic filopodial extensions to migrate in dorsal and ventral directions over the forming midgut tube. The establishment of maximal dorsoventral distances from one another, and anteroposterior alignments, lead to the equidistant coverage of the midgut with longitudinal muscle fibers. We identify Teyrha-Meyhra (Tey), a tissue-specific nuclear factor related to the RNF220 domain protein family, as a crucial regulator of this process of muscle migration and morphogenesis that is further required for proper differentiation of longitudinal visceral muscles. In addition, Tey is expressed in a single somatic muscle founder cell in each hemisegment, regulates the migration of this founder cell, and is required for proper pathfinding of its developing myotube to specific myotendinous attachment sites.