bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival of pleurectomy-decortication and hyperthermic chemotherapy in mesothelioma
Authors: Gül Ergönül Ayşe , Aydın Sercan , Kahraman Aydın Seda , İlker Akçam Tevfik , Özdil Ali , Turhan Kutsal , Çakan Alpaslan , Çağırıcı Ufuk 
Published: September 2023

Background: This study aims to evaluate overall survival, diseasefree survival, and prognostic factors in patients undergoing pleurectomy-decortication and hyperthermic intrathoracic chemotherapy with the diagnosis of malignant pleural mesothelioma.
Methods: Between January 2020 and November 2021, a total of 53 patients (27 males, 26 females; mean age: 58.1±1.3 years; range, 39 to 81 years) who underwent pleurectomy-decortication and hyperthermic intrathoracic chemotherapy with the diagnosis of malignant pleural mesothelioma were retrospectively analyzed. Data including characteristics, comorbidities, postoperative complications, recurrence and mortality status of the patients were recorded. Overall survival and disease-free survival and prognostic factors were evaluated.
Results: The median disease-free survival was 11.67 months and the median overall survival was 24.60 months. The median disease-free survival was 8.80 months in men and 13.17 months in women, indicating a statistically significant difference as it showed that recurrence was detected earlier in male patients (p=0.037). The median disease-free survival and overall survival was 6.13 months and 11.70 in cases diagnosed with biphasic mesothelioma, respectively, while it was 11.67 months and 25.46 months in cases with epithelial mesothelioma, respectively. Pathological subtype was found to be an effective prognostic factor for both survival (p=0.049 and p<0.001, respectively).
Conclusion: Hyperthermic intrathoracic chemotherapy following cytoreductive surgery is a preferable and tolerable method in the treatment of malignant pleural mesothelioma. While evaluating surgical indications, it should be kept in mind that cases with epithelial mesothelioma may benefit more from surgical treatment.
IMPLEMENTASI NILAI-NILAI PANCASILA DI ERA PANDEMI COVID-19 DALAM PERSPEKTIF PENDIDIKAN KEWARGANEGARAAN
Authors: Aifan Aifan , Lakuna Rosnani 
Published: September 2023

Pancasia lahir dari perjalanan sejarah bangsa yang dirumuskan oleh para pendiri bangsa ini. Pancasila yang termaktub dalam pembukaan UUD 1945 alenia ke-4 diharapkan dapat dijadikan pedoman hidup bangsa Indonesia. Memaknai nilai-nilai Pancasila harus tetap diamalkan dalam kehidupan sehari-hari bangsa Indonesia, oleh sebab itu keberadaannya tidak hanya dijadikan simbol semata. Nilai-nilai Pancasila harus dipahami secara menyeluruh sehingga tercipta kerukunan bangsa. Sila-sila Pancasila dapat menjadi pedoman bagi bangsa Indonesia untuk mewujudkan sumber daya manusia yang unggul dalam menghadapi berbagai tantangan. Di masa pandemi Covid-19, nilai-nilai Pancasila sangat penting diimplementasikan dalam masyarakat Indonesia, yaitu gotong royong.yang merupakan suatu ciri khas atau karakter dari warganegara Indonesia
La innovación como factor clave del posicionamiento de productos ecuatorianos en el mercado internacional
Authors: Navas Walter , Checa Brandon , Chicaiza Tania 
Published: September 2023

Los autores investigaron cómo la innovación desempeña un papel crucial en la promoción y éxito de los productos de Ecuador en el ámbito global, se analiza cómo las estrategias innovadoras, posibilitan el desarrollo de productos únicos, la incorporación de tecnologías avanzadas y la adopción de prácticas sostenibles, para que las empresas ecuatorianas logren diferenciarse en mercados internacionales altamente competitivos. El problema del sector industrial ecuatoriano es la falta de propuestas de valor en sus modelos de negocios y la crisis logística mundial. Este artículo tiene como objetivo investigar y distinguir las diferentes empresas que han logrado su éxito en base a la innovación y cómo han influido en el mercado internacional, también pretende motivar a los empresarios, emprendedores o comerciantes ecuatorianos y de toda América Latina a que empiecen a ampliar sus horizontes hacia la innovación, nuevos mercados y nuevas industrias. A través de la presente investigación de tipo documental , descriptivo y de carácter cuantitativo, se levantó información al sector manufacturero y de servicios utilizando la herramienta Google forms, lo que permitió examinar profundamente, cómo la innovación es un factor considerable para el posicionamiento de los diversos productos y servicios en el mercado internacional y cómo sin innovación no existe una adecuada competencia en el mercado, así mismo permitió obtener resultados de comparación entre empresas que practican la innovación con aquellas que no lo hacen , conociendo las posibles estrategias para implementar en las industrias del sector y permita que la innovación sea parte de su cultura corporativa.
5-Years of Thrombolytic Treatment Experience
Authors: TUNCAR Alpay , GÜNER Hakan , CANBAZ Hayri , BEŞTEMİR Attila 
Published: September 2023

Objective: Thrombolytic therapy has a vital role in saving both life and vital functions in emergency room patients. Our aim in our study is to reveal the thrombolytic practice experience of a 3rd level hospital in a long period of 5 years.
Methods: Adult patients who applied to the emergency department between 2017-2022 and were given thrombolytic therapy were selected. Demographic information, risk factors, laboratory and radiological parameters, diagnoses and thrombolytic use of the patients were examined.
Results: 56 patients were included in the study. Survival in patients with comorbidity was lower than in patients without comorbidity (p=0.0036). Survival of patients with a history of cerebrovascular occlusion was lower than those without (p=0.01). There was no statistically significant difference in survival between patients who received coagulation therapy in their history and patients (p>0.05). Survival analysis was performed according to the diagnosis of the patients in the emergency department. There was no statistical significance in terms of survival among patients with different diagnosis types (p=0.098). No statistically significant difference was found in the survival analysis for different application sites of thrombolytic therapy as emergency room, clinical service and intensive care unit (p=0.85). It was observed that doctors started thrombolytic practice as of 2017, and the number of applications increased over the years.
Conclusion: The favorable outcomes thrombolytic therapy have led an increase in the number of thrombolytic therapy conducted by ED clinicians while it was also seen that there was a reduction in morbidity and mortality over time.
Gallik Asidin Rahim Ağzı Kanseri Hücre Hattına (HeLa) Karşı Antikanser Etkisi
Authors: SARI Umut , AFŞİN Yasemin , ÖZDEMİR İlhan , MUTLU ÖZÇELİK Serap , ÖZTÜRK Şamil 
Published: September 2023

Amaç: Servikal kanser, kadın infertilitesinde oldukça önemli yer teşkil eden ve dünya çapında kadınları en çok etkileyen dördüncü kanser olarak karşımıza çıkmaktadır. Doxorubicin (Dox), yumurtalık ve meme kanseri tedavisinde en sık reçete edilen kemoterapötiklerdendir. Kemoterapötik ilaçlar çok etkili tedavi sonuçları ile yanıt oluştursalar da, ciddi yan etkileri oluşturmakta ve ilaç direnci gelişmesi bu ilaçların kullanımına kısıtlama getirmektedir. Antikanser aktiviteye sahip doğal ürünlerin kullanılması bu sorunların kısmen üstesinden gelinmesine yardımcı olabilir. Gallik asit (GA), çeşitli bitki ve gıdalarda yaygın olarak bulunur ve çeşitli biyolojik etkilere sahip olduğu bildirilmiştir. Bu çalışmada GA'in ve güçlü bir kemoterapi ajanı olan Dox’in HeLa hücreleri ve insan deri keratinosit hücre hattı (HaCaT) üzerindeki hücre büyümesinin inhibisyonu ve ölümü ile ilgili etkileri MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) yöntemi ile belirlenmesi amaçlanmıştır.
Yöntemler: Çalışmada serviks adenokarsinoma hücre serisi HeLa (CCL-2™) ve sağlıklı hücre serisi olarak insan deri keratinosit hücre serisi HaCat (RRID: CVCL_0038) kullanılmıştır. Dox ve GA’in IC50 (inhibitory concentration) dozlarının belirlenmesi için HeLa ve HaCaT hücre hattı otomatik multipipet yardımı ile ekimi yapılmıştır. Daha sonra hücre sağkalım (viyabilite) analizini yapmak için MTT testi uygulanmıştır.
Bulgular: HeLa hücre büyümesi, Dox ile muamele edilen hücrelerde 48. saatte yaklaşık IC50 137.6 uM iken, GA'in 48. saatteki IC50 değeri 239.2 uM bulunmuştur.
Sonuç: Bu sonuçlar, GA’in Dox’nun etkisini güçlendirdiğini ve Dox/GA asit kombinasyonunun, rahim ağzı kanseri tedavisinde diğer kemoterapötik kombinasyonları için daha düşük yan etkilerle umut verici bir alternatif olabileceğini göstermektedir.
Acil Tıp Uzmanlık Eğitimi Kapsamında Geliştirilen Travma Konulu Çevrimiçi Asenkron E-Öğrenme Modülüne İlişkin Öğrenci Görüşlerinin İncelenmesi
Authors: KARACA Ozan , ALTUNCI Yusuf Ali , YALÇINLI Sercan 
Published: September 2023

Amaç: Travmaya bağlı yaralanmalar acil servis başvurularının önemli bir kısmını oluşturur. Bu hastalara uygun bir şekilde sağlık hizmeti sunulabilmesi için özellikle klinik tecrübesi sınırlı olan hekimlerin bilgi ve beceri açısından hazır bulunuşluklarının artırılması gerekir. Bu çalışmada travma hastalarının değerlendirmesinde yeterli tecrübeye sahip olmayan hekimlerin gözetimli bir şekilde hastalara hizmet vermeye başlamadan önce ilgili konuda bilgi ve beceri düzeylerini artırılması amacıyla hazırlanan bir asenkron e-öğrenme modülünün öğrenci geribildirimleri ile değerlendirilmesi amaçlanmıştır.
Yöntemler: Bu araştırma, Acil Tıp Uzmanlık Eğitimi programında öğrenim gören Travma konulu e-öğrenme modülünün uygulandığı 39 öğrenciden 28’inin ders geribildirim verilerinin tanımlayıcı olarak analizi edildiği retrospektif bir çalışmadır. Öğrencilerin görüşleri 18 likert tipi, 2’de açık uçlu sorudan oluşan bir elektronik anket aracılığıyla toplanmıştır.
Bulgular: Çalışmanın bulguları, travma konulu asenkron e-öğrenme modülünün öğrenciler için esnek ve erişilebilir bir öğrenme ortamı sağlaması açısından etkili bulunduğunu göstermiştir. Öğrenciler modülün içeriğini kolay anlaşılır bulmuş ve içeriğe tekrar tekrar erişebilmeleri olumlu bir özellik olarak değerlendirmiştir.
Sonuç: Asenkron e-öğrenme, acil tıp uzmanlık eğitiminde teorik içeriğin öğretilmesi için öğrenenler tarafından benimsenen esnek, öğrenen merkezli ve etkili bir yöntem olmasının yanı sıra, eğiticiler ve öğrenenler için klinik ortamlarda pratik eğitim için daha fazla zaman olanağı da sağlamaktadır.
NGHIÊN CỨU TÍNH AN TOÀN VÀ PHÙ HỢP TRONG SỬ DỤNG THUỐC ỨC CHẾ BƠM PROTON Ở BỆNH NHÂN NGOẠI TRÚ ĐIỀU TRỊ DỊCH VỤ TẠI KHOA KHÁM BỆNH, BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2022- 2023
Authors: Nguyễn Hữu Trúc , Nguyễn Thanh Liêm , Nguyễn Thị Thu Hiền , Đặng Duy Khánh 
Published: September 2023

Đặt vấn đề: Nhằm tối ưu hóa hiệu quả điều trị, xác định thực trạng và đánh giá tính an toàn và phù hợp sử dụng thuốc ức chế bơm proton là cần thiết. Mục tiêu nghiên cứu: Mô tả đặc điểm và đánh giá sự an toàn, phù hợp sử dụng các thuốc nhóm PPI ở bệnh nhân ngoại trú dịch vụ tại Khoa Khám bệnh, Bệnh viện trường Đại học Y Dược Cần Thơ năm 2022-2023. Đối tượng và phương pháp nghiên cứu: 520 đơn thuốc ngoại trú dịch vụ tại khoa khám bệnh, Bệnh viện Trường Đại học Y Dược Cần Thơ được kê đơn thuốc PPI từ tháng 09/2022-04/2023. Đánh giá tính phù hợp căn cứ theo tờ hướng dẫn sử dụng nhà sản xuất, phác đồ điều trị Bộ y tế; xác định tính an toàn dựa vào kết quả tra cứu tương tác thuốc từ 02 công cụ Drugs.com và Medscape.com Kết quả: Tỷ lệ cao nhất nhóm tuổi được kê đơn thuốc PPI là độ tuổi lao động 18-59 tuổi (63,85%), trong khi nhóm <18 tuổi có tỷ lệ thấp nhất (3,85%). Tỷ lệ nữ cao hơn nam (59,23% và 40,77% tương ứng). Thời gian điều trị thuốc PPI cao nhất là ≥ 14 ngày 78,65%. Esomeprazole là loại thuốc PPI được sử dụng nhiều nhất (46,92%), tiếp theo là Pantoprazole (22,31%), và Lansoprazole có tỷ lệ thấp nhất (0,39%). Tỷ lệ đơn thuốc có tương tác là 15,96%, đơn thuốc PPI không phù hợp là 8,56%, không an toàn là 15,19%, không phù hợp và không an toàn là 20,77%. Kết luận: Tỷ lệ sử dụng thuốc PPI không phù hợp và không an toàn khá cao. Điều này có thể ảnh hưởng đến hiệu quả và chi phí điều trị. Truyền thông và thông tin thuốc cần được tăng cường để đảm bảo hiệu quả điều trị, sử dụng thuốc an toàn và tiết kiệm cho bệnh nhân. Từ khóa: Thuốc ức chế bơm proton (PPI), ngoại trú, trường Đại học Y Dược Cần Thơ.
NGHIÊN CỨU BÀO CHẾ KEM Ủ TÓC MEN BIA HỖ TRỢ PHỤC HỒI TÓC HƯ TỔN
Authors: Đào Long Châu , Đinh Kiều Minh Anh , Nguyễn Thị Cẩm Duyên , Cao Lâm Gia Hân , Lê Ngọc Hân , Nguyễn Thị Thu Huyền , Trần Cao Trúc Linh , Phạm Nguyễn Quốc Thông , Võ Đào Thảo Vy , Nguyễn Ngọc Nhã Thảo 
Published: September 2023

Đặt vấn đề: Ngày nay, dịch vụ làm đẹp cho tóc rất phát triển cùng với các yếu tố môi trường dẫn đến mái tóc bị hư tổn nên việc chăm sóc và phục hồi tóc ngày càng được quan tâm. Được biết men bia qua quá trình chuyển hóa tạo ra các thành phần có lợi cho tóc nhưng có rất ít nghiên cứu nói về tác dụng trên tóc. Hiện nay, ở Việt Nam và trên thế giới có một số chế phẩm chăm sóc tóc có thành phần men bia nhưng vẫn còn ít công trình nghiên cứu nào được công bố. Mục tiêu nghiên cứu: Xây dựng công thức bào chế kem ủ tóc men bia hỗ trợ phục hồi tóc hư tổn và khảo sát tác dụng phục hồi của sản phẩm. Đối tượng và phương pháp nghiên cứu: Kem ủ tóc men bia được bào chế bằng phương pháp nhũ hóa trực tiếp và sản phẩm đối chứng Kem ủ tóc Watsons. Xây dựng tiêu chuẩn cơ sở dựa theo quy định của Dược điển Việt Nam V đối với thuốc mềm dạng kem. Khảo sát tác dụng của chế phẩm trên 3 nhóm đối tượng với các mức độ tổn thương tóc khác nhau dưới kính hiển vi điện tử quang học. Kết quả: Đã nghiên cứu thành công kem ủ tóc men bia với công thức F10 đáp ứng các chỉ tiêu về độ bền, độ dàn mỏng, độ bám dính, độ ổn định, tính kích ứng, hình thức cảm quan, độ đồng nhất, độ pH và định tính. Sau 3 tuần khảo sát nhận thấy có sự phục hồi tóc trên 6 tình nguyện viên tham gia chứng minh bằng sự giảm bậc hư tổn của tóc. Kết luận: Kem ủ tóc men bia có tác dụng phục hồi tóc hư tổn từ mức độ nặng (cấp 3) đến nhẹ (cấp 1).
Hydrogen rich gas production from pyrolysis-gasification of biomass with combined catalyst and sorbent
Authors:   , Bunma Teerayut 
Published: September 2023

In this work, the hydrogen production during biomass steam pyrolysis-gasification with a combined catalysts and sorbent (catalyst/sorbents) was studied in a drop tube two-stages fixed bed reactor. The catalyst/sorbents were prepared by an excess-solution impregnation method. A nickel oxide (NiO)/magnesium oxide (MgO)/calcium oxide(CaO) catalyst/sorbents containing 10 wt. % NiO, 5 wt. % MgO and 5 wt. % CaO on gamma alumina (γ-Al2O3) showed the best activity in sorption enhanced hydrogen production (SEHP) for the pyrolysis-gasification of sugarcane leaves. Besides, the highest H2 concentration and the lowest CO2 concentration were attained using the Mg5Ni10Ca5 catalyst/sorbents. Because Mg5Ni10Ca5 catalyst/sorbents provided the dominant phases of CaO which can increase the CO2 adsorption capacity to promote the H2 production. Moreover, the synergistic effect between CaO and MgO sorbents which were prepared by dry- and wet-physical mixing with different molar ratios were investigated. The results indicated that the wet-mixed sorbent with the molar ratio between CaO and MgO of 2:1 (WM 2:1) afforded a higher H2 yield because the Ca(OH)2 phases in the wet-mixed sorbents induced high performance for SEHP. Furthermore, the devolatilization and gasification temperature of 600 oC gave the optimal condition for SEHP. The effect of NiO loading content on WM(2:1) was also examined for the H2 production. The results showed that NiO 5 wt.% on WM (2:1) sorbents showed the optimal yield and concentration of H2. The obtained results will be useful for the effective development of combined catalyst/sorbents for SEHP of biomass pyrolysis-gasification
Nanomaterial sensors for selective detection of biothiol compounds
Authors:   , Chaicham Chiraporn 
Published: September 2023

Novel nanomaterial sensors have been designed two different strategies of sensing approach. The first sensing system, the aggregation nanomicelles (TSC and TSD) were synthesized for GSH sensing based on disulfide-cleavaged trigger in the micelle. The result showed a large quenching fluorescent intensity around 587 nm and 528 nm corresponding to TSC and TSD, respectively, upon the addition of GSH in 2.5% DMSO/PBS at pH 6. Additionally, the benefit of TSD is utility for the distance-based fluorescence detection of 3D paper analytical device (3D-µPAD) for the detection of GSH.

Apart from GQDs sensors base, we demonstrated the utility and board applicability of GQDs/AuNPs nanohybrid with measurements of Cysteine (Cys) and Lysine (Lys) using UV-Visible and fluorescent spectroscopy, respectively. For Cys sensing approach, the Cys enable to induce the self-aggregation of GQDs/AuNPs resulting in the color change from red to blue and red shift from 525 nm to 645 nm. On the other hand, Lys exhibited the fluorescence recovery at 450 nm belonging to emission band of GQDs. This is indicative of the displacement of Lys on AuNPs and releasing free GQDs in the solution. This sensor provided a high selectivity toward Cys and Lys with LOD of 5.88 µM and 16.14 µM, respectively. Furthermore, GQDs/AuNPs offered an efficient quantitative determination of Cys in urine samples and Lys in milk samples with real time analysis and highly specific detection.
การเปลี่ยนแปลงของเซลล์เม็ดเลือดขาวที่ได้รับสัญญาณจากเซลล์มะเร็งรังไข่ชนิดเยื่อบุผิว
Authors:   , สนธิ นัทธมน 
Published: September 2023

สัญญาณพาราไครน์ (paracrine signal) เป็นการสื่อสารระหว่างเซลล์ 2 เซลล์ที่อยู่ใกล้กัน ซึ่งสามารถทำให้เกิดการเปลี่ยนแปลงของเซลล์ที่ได้รับสัญญาณได้ มีการศึกษาก่อนหน้าพบว่า เซลล์มะเร็งเต้านมมีการส่งสัญญาณไปยังเซลล์เม็ดเลือดขาวทำให้เกิดการเปลี่ยนแปลงในระดับโมเลกุล ซึ่งนำไปสู่การพัฒนาวิธีการตรวจโรคจากการตรวจเลือด และเป็นประโยชน์อย่างยิ่งในการประยุกต์ใช้กับโรคมะเร็งชนิดต่างๆ โดยเฉพาะโรคมะเร็งรังไข่ที่มีความหลากหลายของเซลล์ และวิธีการตรวจคัดกรองยังมีประสิทธิภาพไม่มากพอ ทำให้ผู้ป่วยมะเร็งรังไข่ยังมีอัตราการเสียชีวิตสูง ดังนั้นงานวิจัยนี้จึงมีวัตุประสงค์เพื่อพัฒนาวิธีการตรวจคัดกรองมะเร็งรังไข่ โดยการวิเคราะห์การเปลี่ยนแปลงการแสดงออกของยีนในเซลล์เม็ดเลือดขาวปกติที่เลี้ยงร่วมกับเซลล์มะเร็งรังไข่ชนิดเยื่อบุผิว 2 ประเภท เปรียบเทียบกับเซลล์เม็ดเลือดขาวปกติกลุ่มควบคุม ผลการวิเคราะห์ด้วยเทคนิค RNA-sequencing (RNA-seq) พบว่า เซลล์เม็ดเลือดขาวกลุ่มทดลองมีการแสดงออกของยีนเปลี่ยนแปลงไปอย่างมีนัยสำคัญทางสถิติ เมื่อนำผล RNA-seq มาคัดเลือกยีนที่สนใจร่วมกับการทดลอง expression array (GSE31682) พบว่า ยีน CDKN1B GIMAP8 และ SNN มีการแสดงออกเพิ่มขึ้นอย่างมีนัยสำคัญ และผลการตรวจสอบการแสดงออกของยีนที่สนใจในเซลล์เม็ดเลือดขาวของผู้ป่วยมะเร็งรังไข่ชนิดเยื่อบุผิวเปรียบเทียบกับคนปกติ ด้วยเทคนิค quantitative reverse transcription polymerase chain reaction (RT-qPCR) พบว่า ยีน GIMAP8 มีการแสดงออกเพิ่มขึ้นในผู้ป่วยมะเร็งรังไข่อย่างมีนัยสำคัญทางสถิติที่ p-value < 0.0001 การศึกษานี้แสดงให้เห็นว่า เซลล์เม็ดเลือดขาวมีการเปลี่ยนแปลงการแสดงออกในระดับโมเลกุลเมื่อได้สัญญาณจากเซลล์มะเร็งรังไข่ชนิดเยื่อบุผิว ซึ่งการแสดงออกของยีน GIMAP8 ที่เพิ่มขึ้นในเซลล์เม็ดเลือดขาวสามารถนำไปใช้ตรวจโรคมะเร็งรังไข่ได้ นอกจากนี้ความรู้ที่ได้จากงานวิจัยนี้ยังเป็นพื้นฐานที่สามารถศึกษาต่อยอดเพื่อการพัฒนาวิธีการตรวจคัดกรอง การวินิจฉัยและการรักษาโรคมะเร็งในอนาคต
ผลฉับพลันของการนวดตนเองที่มีต่อความเมื่อยล้าของกล้ามเนื้อในพนักงานสำนักงาน
Authors:   , แสวงพรรค นัชชา 
Published: September 2023

การวิจัยในครั้งนี้มีวัตถุประสงค์ เพื่อศึกษาและเปรียบเทียบผลฉับพลันของการนวดตนเองด้วยมือ และนวดตนเองโดยใช้อุปกรณ์แบ็คน็อบเบอร์ ทู ที่มีต่อความเมื่อยล้าของกล้ามเนื้อบริเวณอัพเพอะ ทราพิเซียสในพนักงานสำนักงาน กลุ่มตัวอย่างเป็นพนักงานสำนักงานเพศชายและหญิงที่มีอายุ 25 - 45 ปี จำนวน 17 คน โดยกลุ่มตัวอย่างทุกคนทำการทดลองทั้ง 3 สภาวะ ได้แก่ การนวดตนเองด้วยมือ การนวดตนเองโดยใช้อุปกรณ์แบ็คน็อบเบอร์ ทู และการนั่งพักเฉยๆ บนเก้าอี้ เว้นระหว่างสภาวะการทดลองเป็นระยะเวลาอย่างน้อย 1 สัปดาห์ โดยประเมินระดับความรู้สึกเมื่อยล้าด้วยแบบประเมินมาตรวัดตัวเลข (Numerical Rating Scale) และบันทึกค่าคลื่นไฟฟ้ากล้ามเนื้อ (Electromyography) เพื่อหาค่าการหดตัวของกล้ามเนื้อสูงสุด (Maximum voluntary contraction) ก่อนและหลังการทดลอง นำผลที่ได้มาวิเคราะห์เปรียบเทียบภายในกลุ่มด้วยค่าทีรายคู่ (Paired t-test) และวิเคราะห์ความแปรปรวนทางเดียวชนิดวัดซ้ำ (One-way ANOVA with Repeated Measures) หากพบความแตกต่างจึงเปรียบเทียบความแตกต่างของค่าเฉลี่ยแบบรายคู่ (Post hoc test) ด้วยวิธีของบอนเฟอโรนี (Bonferroni) ที่ระดับความมีนัยสำคัญทางสถิติ 0.05

ผลการวิจัยพบว่า ค่าเฉลี่ยของระดับความรู้สึกเมื่อยล้าของกล้ามเนื้อหลังการทดลองทั้ง 3 สภาวะมีค่าลดลง ค่าเฉลี่ยของค่าร้อยละการหดตัวของกล้ามเนื้อหลังการทดลองทั้ง 3 สภาวะมีค่าเพิ่มขึ้น และเมื่อเปรียบเทียบความแตกต่างของค่าเฉลี่ยระดับความรู้สึกเมื่อยล้าของกล้ามเนื้อ และค่าเฉลี่ยร้อยละการหดตัวของกล้ามเนื้อ พบว่าหลังการทดลองการนวดตนเองด้วยมือและการนวดตนเองโดยใช้อุปกรณ์แบ็คน็อบเบอร์ ทู ไม่แตกต่างกัน

สรุปผลการวิจัย การนวดตนเองด้วยมือและการนวดตนเองโดยใช้อุปกรณ์แบ็คน็อบเบอร์ ทู บริเวณกล้ามเนื้ออัพเพอะ ทราพิเซียส ระยะเวลา 15 นาที ทำให้พนักงานสำนักงานมีความรู้สึกเมื่อยล้าของกล้ามเนื้อลดลง และกล้ามเนื้อมีการหดตัวดีขึ้น
Fabrication of silver nanofilament based on silver sulfide solid electrolyte for tip-enhanced raman spectroscopy
Authors:   , Fueaimi Phichaya 
Published: September 2023

Surface science analysis is the crucial fundamental of nanoscale study. The techniques combined morphological and compositional study on the surface are the promising technique. Tip-enhanced Raman spectroscopy (TERS) is the coupling of atomic force microscopy (AFM) and Raman spectroscopy which give the 3D- images and bonding information in ambient conditions. Furthermore, TERS tip is an ideal tool for the high enhancement and spatial resolution. Nowadays, TERS tip fabrication is still challenged. There are three main challenges that are high enhancement factor of the TERS tip, reproducibility of the tip and in-depth understanding of TERS process. We introduce the simple method for fabrication of silver nanofilaments (Ag NFs) based on β-silver sulfide (β-Ag2S) solid electrolyte for TERS. The highest amount of β-Ag2S was synthesized from 0.5 mM for 6 hours at pH 8.45 by chemical bath deposition (CBD). The highest density and length were achieved from 20 kV of accelerated voltage and 10 minutes by electron beam irradiation. The highest density and length of Ag NFs were found to be 5.93 x 109 NF/cm2 and 0.46 ± 0.04 µm, respectively. The Ag NFs performance has been investigated by using Ag NFs as surface enhanced Raman spectroscopy (SERS) substrates. Methylene blue (MB) adsorbed on Ag NFs substrate with green laser (532 nm) and the maximum SERS enhancement factor of 1.57x106 was achieved. The limit of detection of MB obtained from Ag NFs substrate was found to be at 10 nM. The highest enhancement factor of 4.27x 104 of MB absorb on Ag NFs TERS tip performed as SERS substrate was achieved.