bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan produk sambal roa inovatif melalui formulasi undur-undur laut
Authors: Riyanto Bambang , Syafitri Utami Dyah , Trilaksani Wini , Ulya Immatul 
Published: September 2023

Sambal roa merupakan salah satu sambal khas nusantara dengan rasa dan aroma ikan roa asap yang khas. Produksi ikan roa yang terus menurun menuntut adanya inovasi pengembangan produk. Undur-undur laut merupakan bahan pengganti yang potensial, karena memiliki cita rasa krustasea/rebon yang mirip dengan terasi serta kandungan karotenoid yang dapat berperan sebagai pewarna alami. Penelitian ini bertujuan untuk menentukan formula sambal roa inovatif melalui formulasi cabai, ikan roa asap, dan undur-undur laut menggunakan I-optimal mixture amount design. Penelitian meliputi modifikasi, pembuatan, dan uji sensori deskriptif sambal roa, optimasi formulasi sambal roa dengan undur-undur laut, serta perbandingan antara sambal roa dengan undur-undur laut dan sambal roa komersial. Formula sambal roa didasarkan pada jumlah total campuran sebesar 150 g dengan proporsi cabai 40%-70%, ikan roa asap 20%-30%, dan undur-undur laut 35%-50%. Hasil formulasi tersebut, diperoleh keberterimaan optimal dengan proporsi cabai 40%, ikan roa asap 21,68%, dan undur-undur laut 38,32%. Karakteristik sambal roa inovatif dengan formulasi cabai, ikan roa asap, dan undur-undur laut adalah berbentuk pasta, memiliki viskositas 9.547±948,54 cP, warna oranye kemerahan L*: 19,64±0,76, a*: 17,58±0,80, dan b*: 22,75±0,68. Sensori aroma khas krustasea (undur-undur laut) dapat dirasakan, serta memiliki sensasi pedas dengan kadar kapsaisin 701,78±0,028 ppm, kadar protein 11,32±0,007%, kadar lemak 15,28±0,049%, aktivitas air (Aw) 0,84±0,0001, dan total mikrobiologi 6,3×10²±1,90 koloni/g.
Küçük hücreli akciğer kanserinde daha fazla kombine kemoterapi ile atezolizumab kullanımı sağkalımı uzatır mı?
Authors: DEMİR Bilgin , AKGÜL Ömer Faruk , AYTAÇ Ali , AÇLAN Ayhan , BALÇIK Onur Yazdan , UZUN Mehmet , OKTAY Esin 
Published: September 2023

Amaç: Küçük hücreli akciğer kanserinde (KHAK) yaklaşık 50 yıldır standart birinci basamak tedavi platin bazlı kemoterapi ile kombine etoposid rejimidir. Atezolizumabın yaygın evre KHAK birinci basamak tedavisinde kemoterapi ile kombine kullanımı yakın zamandan sağkalımı iyileştirdiği randomize bir çalışmada gösterilmiştir. Immunoterapi tedavisi uygulanmayan KHAK’li hastalara standart 6 kür platin bazlı kemoterapi uygulanarak en etkili sağkalım sonuçlarına ulaşılırken, atezolizumabın randomize çalışmasında standart 4 kür kemoterapi uygulanmıştır. Bu retrospektif çalışma, yaygın evre KHAK birinci basamak tedavisinde 6 kür kemoterapi ile kombine atezolizumabın gerçek yaşam verilerini sunmayı amaçlamaktadır.
Gereçler ve Yöntemler: Çalışmaya kliniğimizdeki yaygın evre KHAK tanılı ve birinci basamak indüksiyon fazında karboplatin-etoposid artı atezolizumab ile kombine minimum 6 siklus tedavi alan hastalar dahil edildi. İndüksiyon fazı tamamlanan hastalara idame fazında atezolizumab 1200 mg 3 haftada bir uygulandı. İndüksiyon fazında 6 siklus atezolizumab ile kombine kemoterapiden az tedavi alan hastalar ile laboratuvar verileri eksik olan hastalar çalışma dışı bırakıldı. Hastaların özellikleri, uygulanan tedaviler ve tedaviye yanıt oranları ile sağ kalım verileri incelendi. Sağkalımı verilerini belirlemek için Kaplan-Meier testi kullanıldı ve metastaz bölgelerinin etkileri log-rank testi kullanılarak analiz edildi.
Bulgular: Kriterleri karşılayan 24 hasta dahil edildi. Ortanca yaş 64 idi ve üçte ikisinde komorbid hastalık vardı. Medyan kemoterapi döngüsü sayısı 6 (6-12) ve atezolizumab döngüsü 8 (6-54) idi. Medyan 9,4 aylık takipten sonra medyan progresyonsuz sağkalım (PFS) ve genel sağkalım (OS) sırasıyla 9.5 ay (%95 GA 0.0-25.8) ve 30,1 aydı (%95 GA 3.26-57.004). Genel yanıt oranı %87.5 idi. Metastatik bölge sayısı (p = 0.77) ile OS arasında anlamlı bir fark bulunamadı. Hastaların yarısından fazlasında derece 3 yan etki gözlendi. En sık yan etkiler hematolojikdi ve toksisiteler yönetilebilirdi.
Sonuç: Bu gerçek yaşam verileri, yaygın evre KHAK birinci basamak tedavisinde indüksiyon fazında en az altı siklus kemoterapi ile kombine atezolizumab etkiliğini ve güvenliliğini doğrulamaktadır.
Apresentação
Authors: Magnaghi Alberto , Campello Cabral Renata , Monteiro de Andrade Carlos Roberto 
Published: September 2023

Esse texto é a apresentação feita pelo urbanista italiano Alberto Magnaghi ao volume Del Destino della Città, uma antologia de textos de Choay traduzidos para o italiano e publicada em 2008.
A antologia organizada por Magnaghi inclui oito textos de Pour une Anthropologie de l’Espace (2006). A eles Magnaghi acrescentou apenas a introdução de Choay às Mémoires do Barão Haussmann, publicada em 2000. As seções são em número de três e pensadas a partir da ótica de um “arquiteto-urbanista militante”, o que o leva a articular as reflexões que permeiam os textos de Choay com os desafios contemporâneos dos profissionais do campo do planejamento urbano, em diálogo direto com princípios caros à Escola Territorialista Italiana.
Alberto Magnaghi é Professor Ordinário Emérito de Planejamento Territorial no Departamento de Arquitetura da Universidade de Florença (DIDA), onde fundou e dirigiu o Laboratório de Projeto Ecológico dos Assentamentos (LaPEI) entre 1990 e 2016. Foi coordenador de um programa nacional de pesquisa e laboratórios experimentais sobre os temas do desenvolvimento local autossustentável e da representação identitária do território (1986-2010), tendo também coordenado diversos projetos e planos urbanísticos. Foi, ainda, presidente do Curso de Láurea Magistral em Planejamento e Projeto da Cidade e do Território junto ao Departamento de Ciências e Tecnologias Agrárias, Alimentares, Ambientais e Florestais (DAGRI). É presidente da Sociedade dos Territorialistas desde sua fundação, em 2011.
Nessa tradução, os termos estrangeiros usados por Magnaghi foram mantidos, de forma a aproximar o leitor brasileiro à experiência tida pelo leitor italiano. Muitos desses termos são em francês e indícios da aproximação de Magnaghi às interpretações feitas por Françoise Choay. Frases muito longas tornaram-se, por vezes, mais de uma sentença, em favor da clareza do texto. Os neologismos foram mantidos como tais, a partir de criação equivalente em português. Anota-se, por fim, que, na tradução das referências, foi feita normatização a partir da ABNT.

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Peran Bahasa dalam Konstruksi Hukum di Indonesia
Authors: Abdillah Kudrat , Moh Faridi  , Lian fawahan  
Published: September 2023

Peranan bahasa dalan konstruksi hukum memiliki makna yang sangat penting dalam perumusan norma-norma perundang-undangan di Indonesia. Ilmu hukum adalah ilmu pengetahuan yang berusaha menelaah tentang hukum yang ada, oleh karenanya ilmu hukum memiliki cara dangan mengunakan logikanya sendiri, yaitu logika hukum dan untuk kebutuhan, kepentingan keberfungsian keilmuannya baik bidang akademik maupun bidang praktis. Rumusan masalah yang akan diteliti adalah meliputi bagaimana peran bahasa dalam rekonstruksi hukum di Indonesia dan bagaimana seharusnya bahasa berperan dalam rekonstruksi hukum di Indonesia. Dalam artikel menekankan pada studi rancangan perundang-undangan. Dari studi ini dapat disimpulkan bahwa hukum memiliki bahasanya sendiri yang tidak sama dengan bahasa pada umumnya, yaitu bahasa hukum yang merupakan hadil dari rekonstruksi hukum itu sendiri. Ilmu hukum dengan segala stratifikasi keilmuannya dan struktur atau klasifikasi hukumnya beserta segala elemen-elemen pendukung sistemnnya sarat dengan bahasa-bahasa hukum yang mengandung artikulasi karakteristik sebagai bahasa keilmuan hukum dan praksis, sehingga untuk memahami disiplin keilmuannya dengan baik, maka harus menggunakan bahasanya sendiri yaitu bahasa hukum.
Apresiasi Negara Terhadap Penyelesaian HAK Asuh Anak Melalui Mediasi
Authors: Faisal Nor , Abdul Hamid Bashori  
Published: September 2023

Indonesia sebagai suatu negara yang berdaulat memliki kewajiban untuk melindungi segenap bangsa Indonesia sebagaimana yang diamanatkan oleh UUD NR Indonesia. Salah satu wujud dari perlindungan tersebut adalah keluarnya serangkaian aturan-aturan berkenaan dengan hak asuh anak untuk pasangan yang terjadi pertikaian akiat perceraian. Tujuan penelitian ini adalah untuk mengungkap bagaimana apresiasi dan konstribusi negara terhadap penyelesaian hak asuh anak melalu mediasi. Penelitian ini menggunakan penekatan kualitatif dengan jenis penelitian library research di mana sumber data akan banyak diperoleh dari berbagai artikel, buku, dan kepustakaan lainnya. Hasil penelitian ini menunjukkan bahwa negara memliki kontribusi besar di dalam memberikan perlindungan kepada anak yang orang tuanya mengalami perceraian. Hak asuh anak sebagaimana yang dikelaskan oleh KHI dan UUP 1974), dimana hak asuh anak yang berumur di bawah 12 tahun (belum mumayyiz) adalah hak dari seorang Ibu selama seorang ibu tersebut patuh dan tunduk kepada aturan syariat dan peraturan perundang-undangan. Namun demikian, negara masih memerikan celah untuk dapat menyelesaikan persoalan tersebut melalui mediasi yang dilakukan antara ke-dua belah pihak. Di samping itu, lahirnya Peraturan Mahkamah Agung Nomor 1 Tahun 2016 dapat dijadikan sebagai rujukan dalam pelaksanaan mediasi di Pengadilan. Peraturan ini sekaligus menunjukkan bahwa negara hadir dan memberikan apresiasi sebesar-besarnya terhadap upaya pengelesaian sengketa hak asuh anak melalui proses mediasi
Les organoïdes intestinaux des animaux de rente : de nouveaux modèles de culture in vitro pour une meilleure compréhension du fonctionnement de l’intestin
Authors: WIEDEMANN Agnès , LACROIX-LAMANDÉ Sonia 
Published: September 2023

L’intestin est un organe complexe aux fonctions multiples. En effet, il participe à la digestion et l'absorption des nutriments et protège l’individu des agressions par des agents pathogènes intestinaux en assurant un rôle de barrière. L’étude de ce compartiment digestif reste toutefois limitée par l’accès aux tissus que ce soit chez l’Homme ou l’animal. Dans ce contexte, le développement d’organoïdes intestinaux à partir de cellules souches représente une avancée technologique importante dans l’étude de la physiopathologie intestinale. De plus, cet outil permet de répondre à une demande sociétale visant à réduire l’usage d’animaux modèles pour la recherche et s’inscrit dans la démarche des 3Rs (Remplacement, Réduction et Raffinement).L’objectif de cette revue est, à partir de rappels de la fonction digestive, de faire un état des lieux sur les différents types d’organoïdes intestinaux existants dérivés d’animaux de rente et de discuter leurs avantages, leurs limites et surtout leur application.
Digital Scrapbook for Learning Recount Text in Junior High School
Authors: Salsabillah Audy , Mayuni Ilza 
Published: September 2023

This study aimed to see the relevance of the contents of digital scrapbooks published by Kate Hadfield Designs with the Curriculum 2013 to learn recount text in Junior High School. The research data were the sentences which were stated in twenty digital scrapbooks from the Kate Hadfield Designs website katehadfielddesigns.com and Pinterest of Kate Hadfield Designs. The generic structure analysis proved that all the elements implemented in the text are well structured. The majority of the texts of digital scrapbooks have been written in the form of a language feature of recount text stated by experts. Nevertheless, the researcher still found several language features missing from some of the texts. For the social function, all the digital scrapbooks were in line with the Curriculum 2013. Furthermore, it could be concluded that the digital scrapbooks analyzed in this research accomplished the necessity of adequate recount text and was relevant with the Curriculum 2013.
Unified metagenomic method for rapid detection of bacteria, fungi and viruses in clinical samples
Authors: Alcolea-Medina Adela , Alder Christopher , Snell Luke , Charalampous Themoula , Aydin Alp , Nebbia Gaia , Williams Tom , Goldenberg Simon , Douthwaite Samuel , Batra Rahul , Cliff Penelope , Mischo Hannah , Neil Stuart , Wilks Mark , Edgeworth Jonathan 
Published: September 2023

Abstract

Clinical metagenomic sequencing can detect microorganisms causing infection directly from clinical samples. Depletion of host DNA is key to increasing sensitivity and reducing turnaround time (TAT). Several human DNA depletion methods have been previously published for detecting microorganisms with DNA and RNA genomes in clinical samples using metagenomics techniques, however, these methodologies only allow for the detection of either DNA or RNA microbes, but not both simultaneously. Thus, we have developed a mechanical-based human DNA depletion method that allows simultaneous detection of RNA and DNA microorganisms, including viruses, bacteria and fungi, directly from clinical samples using Oxford Nanopore Technology. The method is technically easy and rapid to perform and successfully removes human DNA from the samples, decreasing human DNA detection with a media of eight Ct values. Workflow detects a broad range of organisms: RNA & DNA viruses, bacteria (Gram-negative and Gram-positive and atypical respiratory pathogens (legionella, chlamydia, mycoplasma) and fungi (Candida, Pneumocystis, Aspergillus)​ 2-hour reports have > 90% sensitivity for bacterial and viral detection compared with routine laboratory results. Positive results are first reportable after 30 min sequencing in a 7h end-to-end workflow.​ The whole genome sequence was achieved in 42% of the viruses detected.
Identifying the genetic links between Parkinson’s disease and non-motor symptoms: novel insights into disease mechanisms
Authors: O'Sullivan Justin , Gokuladhas Sreemol , Fadason Tayaza , Farrow Sophie , Cooper Antony 
Published: September 2023

Abstract
Understanding the biological mechanisms that underlie the non-motor symptoms of Parkinson’s disease (PD) requires comprehensive frameworks that unravel the complex interplay of genetic risk factors. Here, we used a disease-agnostic brain cortex gene regulatory network integrated with Mendelian Randomization analyses to identify 19 genes whose changes in expression are causal for PD. We further used the network to identify genes that are regulated by PD-associated genome-wide association study (GWAS) SNPs. Extended protein interaction networks derived from both the causal genes and PD-associated SNPs identified convergent impacts on biological pathways and phenoytpes, connecting PD with established co-occurring traits, including non-motor symptoms. These findings hold promise for therapeutic development. In conclusion, while distinct sets of genes likely influence PD risk and outcomes, the existence of genes in common and intersecting pathways suggests that they may contribute to both increased disease risk and symptom heterogeneity observed in people with Parkinson’s.
Spatiotemporal imaging and shaping of electron wave functions using novel attoclock interferometry
Authors: Liu Yunquan , Ge Peipei , Dou Yankun , Han Meng , Fang Yiqi , Deng Yongkai , Wu Chengyin , Gong Qihuang 
Published: September 2023

Abstract
Electrons detached from atoms by photoionization carry valuable information about light-atom interactions. Characterizing and shaping the electron wave function on its natural timescale is of paramount importance for understanding and controlling ultrafast electron dynamics in atoms, molecules and condensed matter. Here we propose a novel attoclock interferometry to shape and image the electron wave function in atomic photoionization. Using a combination of a strong circularly polarized second harmonic and a weak linearly polarized fundamental field, we spatiotemporally modulate the atomic potential barrier and shape the electron wave functions, which are mapped into a temporal interferometry. By analyzing the two-color phase-resolved and angle-resolved photoelectron interference, we are able to reconstruct the spatiotemporal evolution of the electron wave function in momentum space within the optical cycle, including its amplitude and phase, from which we identify the quantum nature of strong-field ionization and reveal the effect of the spatiotemporal properties of atomic potential on the departing electron. This study provides a new approach for spatiotemporal shaping and imaging of electron wave function in intense light-matter interactions and holds great potential for resolving ultrafast electronic dynamics in molecules, solids, and liquids.
Predicting return of lung function after a pulmonary exacerbation using the cystic fibrosis respiratory symptom diary-chronic respiratory infection symptom scale
Authors: Gill Eliana R. , Goss Christopher H. , Sagel Scott D. , Wright Michelle L. , Horner Sharon D. , Zuñiga Julie A. 
Published: September 2023

Abstract

Background
Pulmonary exacerbations (PExs) in people with cystic fibrosis (PwCF) are associated with increased healthcare costs, decreased quality of life and the risk for permanent decline in lung function. Symptom burden, the continuous physiological and emotional symptoms on an individual related to their disease, may be a useful tool for monitoring PwCF during a PEx, and identifying individuals at high risk for permanent decline in lung function. The purpose of this study was to investigate if the degree of symptom burden severity, measured by the Cystic Fibrosis Respiratory Symptom Diary (CFRSD)- Chronic Respiratory Infection Symptom Scale (CRISS), at the onset of a PEx can predict failure to return to baseline lung function by the end of treatment.
Methods
A secondary analysis of a longitudinal, observational study (N = 56) was conducted. Data was collected at four time points: year-prior-to-enrollment annual appointment, termed “baseline”, day 1 of PEx diagnosis, termed “Visit 1”, day 10–21 of PEx diagnosis, termed “Visit 2” and two-weeks post-hospitalization, termed “Visit 3”. A linear regression model was performed to analyze the research question.
Results
A regression model predicted that recovery of lung function decreased by 0.2 points for every increase in CRISS points, indicating that participants with a CRISS score greater than 48.3 were at 14% greater risk of not recovering to baseline lung function by Visit 2, than people with lower scores.
Conclusion
Monitoring CRISS scores in PwCF is an efficient, reliable, non-invasive way to determine a person’s status at the beginning of a PEx. The results presented in this paper support the usefulness of studying symptoms in the context of PEx in PwCF.
Catastrophizing maladaptive coping affects influence of viral anxiety on fear of progression in cancer patients during COVID-19 pandemic
Authors: Lee Hyuk Joo , Sin Cheolkyung , Kim Hyeyeong , Im Hyeon-Su , Jo Jae-Cheol , Lee Yoo Jin , Kim Youjin , Ahn Junseok , Yoo Soyoung , Koh Su-jin , Chung Seockhoon 
Published: September 2023

Abstract
Background/Aims
The aim of the present study was to explore whether or not cancer patients’ viral anxiety and depression during the coronavirus 2019 (COVID-19) pandemic were associated with a fear of cancer progression. We also assessed whether coping strategies affected the relationship.
Methods
The present cross-sectional survey included cancer patients who visited Ulsan University Hospital in Ulsan, Korea. The participants’ demographic information and responses to the following symptoms rating scales were collected: Stress and Anxiety to Viral Epidemic − 6 (SAVE-6); Patient Health Questionnaire − 9 (PHQ-9); Cognitive Emotion Regulation Questionnaire - short version (CERQ-short); or Fear of Progression Questionnaire - short version (FoP-Q-SF).
Results
Of the 558 cancer patients surveyed, 25 (4.5%) reported that their treatment schedule was delayed during the COVID-19 pandemic. The patients’ fear of progression was found to be related to age (β = -0.08; P = 0.011), viral anxiety (β = 0.40; P < 0.001), depression (β = 0.26; P < 0.001), and catastrophizing coping strategies (β = 0.15; P = 0.004), for an overall adjusted R2 of 0.46 (F = 66.8; P < 0.001). Mediation analysis showed that viral anxiety and depression directly influenced fear of progression, while catastrophizing mediated this relationship.
Conclusions
Fear of progression in cancer patients was influenced by viral anxiety, depression, and maladaptive coping techniques, such as catastrophizing, during the COVID-19 pandemic.
Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1 mutations
Authors: Silverman Jill L. , Fenton Timothy , Haouchine Olivia , Hallam Elizabeth , Smith Emily , Jackson Kiya , Rahbarian Darlene , Canales Cesar , Adhikari Anna , Nord Alex , Ben-Shalom Roy 
Published: September 2023

Abstract
SYNGAP1 is a critical gene for neuronal development, synaptic structure, and function. Although rare, the disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental disorder (NDD) called SYNGAP1-related intellectual disability. Without functional SynGAP1 protein, patients present with intellectual disability, motor impairments, and epilepsy. Previous work using mouse models with a variety of germline and conditional mutations has helped delineate SynGAP1’s critical roles in neuronal structure and function, as well as key biochemical signaling pathways essential to synapse integrity. Homozygous loss of SYNGAP1 is embryonically lethal. Heterozygous mutations of SynGAP1 result in a broad range of phenotypes including increased locomotor activity, impaired working spatial memory, impaired cued fear memory, and increased stereotypic behavior. Our in vivo functional data, using the original germline mutation mouse line from the Huganir laboratory, corroborated robust hyperactivity and learning and memory deficits. Here, we describe impairments in the translational biomarker domain of sleep, characterized using neurophysiological data collected with wireless telemetric electroencephalography (EEG). We discovered Syngap1+/− mice exhibited elevated spike trains in both number and duration, in addition to elevated power, most notably in the delta power band. Primary neurons from Syngap1+/− mice displayed increased network firing activity, greater spikes per burst, and shorter inter-burst intervals between peaks using high density micro-electrode arrays (HD-MEA). This work is translational, innovative, and highly significant as it outlines functional impairments in Syngap1 mutant mice. Simultaneously, the work utilized untethered, wireless neurophysiology that can discover potential biomarkers of Syngap1R-ID, for clinical trials, as it has done with other NDDs. Our work is substantial forward progress toward translational work for SynGAP1R-ID as it bridges in-vitro electrophysiological neuronal activity and function with in vivo neurophysiological brain activity and function. These data elucidate multiple quantitative, translational biomarkers in vivo and in vitro for the development of treatments for SYNGAP1-related intellectual disability.