bluuebunny/crossref_metadata_2025_split huggingface dataset:
From responses of macroinvertebrate metrics to the definition of reference metrics and stressor threshold values
Authors: HOUNYEME Romuald , MAMA Daouda , ARGILLIER Christine 
Published: May 2023

Abstract
The present study focused on using benthic macrofauna to assess the risks of moving away from Good Ecological Status towards the functioning of an anthropized system (Nokoué-Benin), based on defining reference values for macroinvertebrate metrics, stress thresholds and the responses of selected metrics to stressors. The approach used is a combination of a joint species distribution model and Bayesian networks. We used JSDM to select relevant metrics and generate posterior probabilities. We then converted these posterior probabilities into posterior response probabilities for each of the stress levels and fed them into a Bayesian network. To define the reference values of the metrics and the stress thresholds derived from the probability density diagrams for low-pressure levels, we used the responses predicted by the Bayesian network. An application of this approach was then carried out on a lagoon sampled during high and low water periods for three consecutive years (2004-2006), with 33 macroinvertebrate taxa present in all seasons and sampling points, and measurements of 14 environmental parameters used as application data. This study demonstrated a reliable inference, the selection of seven relevant metrics and the definition of reference conditions. The relevance of the metrics and ecological assessment criteria, despite the small sample size, suggests the potential for wider applicability of the approach to aquatic ecosystem monitoring and assessment programs in developing countries, which are generally characterized by a lack of monitoring data.
Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine
Authors: Fonseca Francisco , Haach Vanessa , Bellaver Franciana , Bombassaro Gabrielly , Gava Danielle , Paulino Luciano , Baron Lana , Simonelly Mayara , Araujo Wanessa , Schaefer Rejane , Bastos Ana 
Published: May 2023

Abstract
Influenza-based virosome is an effective immunomodulating carrier that replicates the natural antigen presentation pathway and has tolerability profile due to their purity and biocompatibility. Based on that, this study aimed to develop a polyvalent virosome influenza vaccine containing the hemagglutinin and neuraminidase proteins derived from the swine influenza A viruses (IAVs) H1N1, H1N2 and H3N2 viruses, and to investigate its effectiveness in mice as a potential vaccine for swine. The humoral and cellular immune responses in mice vaccinated intranasally or intramuscularly with polyvalent influenza virosomal vaccine were investigated. Only intramuscular vaccination induced high hemagglutination inhibition (HI) titers. Seroconversion and seroprotection (> 4-fold rise in HI antibody titers, reaching a titer of ≥ 1:40) were achieved in 80% of mice (intramuscularly vaccinated group) at 21 days after booster immunization. Long-lasting immunity was observed 8 months after vaccination. Overall, mice immunized with the virosome displayed greater ability for B, effector-T and memory-T cells from the spleen to respond to H1N1, H1N2 and H3N2 antigens. All findings showed an efficient immune response against IAVs in mice vaccinated with a polyvalent virosome-based influenza vaccine.
Parasite proteostasis and artemisinin resistance
Authors: Rosenthal Melissa , Ng Caroline 
Published: May 2023

Abstract
The continued emergence and spread of resistance to artemisinins, the cornerstone of first line antimalarials, threatens significant gains made toward malaria elimination. Mutations in Kelch13 have been proposed to mediate artemisinin resistance by either reducing artemisinin activation via reduced parasite hemoglobin digestion or by enhancing the parasite stress response. Here, we explored the involvement of the parasite unfolded protein response (UPR) and ubiquitin proteasome system (UPS), vital to maintaining parasite proteostasis, in the context of artemisinin resistance. Our data show that perturbing parasite proteostasis kills parasites, early parasite UPR signaling dictate DHA survival outcomes, and DHA susceptibility correlates with impairment of proteasome-mediated protein degradation. These data provide compelling evidence toward targeting the UPR and UPS to overcome existing artemisinin resistance.
Novel requirements for HAP2-mediated gamete fusion in Tetrahymena.
Authors: Pinello Jennifer , Loidl Joseph , Seltz Ethan , Cassidy-Hanley Donna , Kolbin Daniel , Abdelatif Anhar , Rey Félix , An Rocky , Newberger Nicole , Bisharyan Yelena , Papoyan Hayk , Byun Haewon , Aguilar Hector , Cole Eric , Clark Theodore 
Published: May 2023

Abstract
The ancestral gamete fusion protein, HAP2/GCS1 catalyzes sperm-egg fusion in a broad range of taxa dating to the last eukaryotic common ancestor. Remarkably, HAP2/GCS1 orthologs are structurally related to the class II fusogens of modern-day viruses, and recent studies make clear that these proteins utilize similar mechanisms to achieve membrane merger. To identify factors that may regulate HAP2/GCS1 activity, we screened mutants of the ciliate Tetrahymena thermophila for behaviors that mimic Δhap2/gcs1 knockout phenotypes in this species. Using this approach, we identified two new genes, GFU1 and GFU2, whose products are necessary for the formation of membrane pores during fertilization and show that the product of a third gene, namely ZFR1, may be involved in pore maintenance and/or expansion. Finally, we propose a model that explains cooperativity between the fusion machinery on apposed membranes of mating cells and accounts for successful fertilization in T. thermophila’s multiple mating type system.
SCOPChain: A Blockchain Based Privacy Preserving Framework for Data Service Composition
Authors: khemaissia Rofaida , Derdour Makhlouf , Ferrag Mohamed Amine , Bouhamed Mohammed Mounir 
Published: May 2023

Abstract
Service composition is combining multiple services to provide for user query a new service which uses data from multiple service providers that are incorporated in the composition. In this situation, the data privacy and especially of the service providers can be breached. Therefore, keeping the data privacy during the composition process is crucial by every work in the context of the service composition. Recent approaches rely on a central mediator that can be trusted or not to ensuring the privacy of the service providers during the query execution. The most recent approaches found problems in case of untrusted mediator where they enforce restrictions that can affect the efficiency of their works. Therefore, we propose SCOPChain which preserves the privacy of data service providers during service composition using BlockChain technology. We used a permissioned BlockChain that acts as trusted mediator where it enables users to access to the BC if they get administrator permission. We use a BC framework called Hyperledger Fabric to implement our solution where it stores sensitive data about the composition whereat intermediate query results are saved in IPFS that acts as offchain storage. As a proof of concept, we have tested SCOPChain on a real-world medical dataset to show its feasibility and efficiency for maintaining privacy in a secure and trusted manner.
Open Educational Resources im inklusiven Unterricht: Eine qualitative Interviewstudie zu Nutzungspraktiken und Weiterbildungsbedarfen von Lehrpersonen
Authors: Berger Jessica , Maitz Katharina , Gasteiger-Klicpera Barbara 
Published: May 2023

Das Konzept der Open Educational Resources (OER) wurde ursprünglich im Hochschulkontext entwickelt, wird jedoch immer mehr auch im Schulbereich genutzt. Die vorliegende Studie geht der Frage nach, welches Wissen österreichische Lehrer*innen zum Thema OER haben, wie sie diese im inklusiven Unterricht einsetzen und welche Wünsche und Bedarfe sie hinsichtlich dieses Themas sowohl im Hinblick auf Aus-, Fort- und Weiterbildungen, als auch in Bezug auf den Einsatz von OER im Unterricht äußern. Mithilfe eines halbstandardisierten Interviewleitfadens wurden im Frühjahr/Sommer 2022 elf österreichische Lehrpersonen befragt. Aus den Ergebnissen der Interviews geht hervor, dass die überwiegende Mehrheit der Befragten bisher keine oder kaum Berührungspunkte mit dem Begriff OER hatte. Dennoch zeigte sich, dass jede der elf Lehrpersonen regelmäßig OER im Unterricht nutzt, auch wenn die genaue Abgrenzung zwischen OER und Materialien, die nicht unter freier Lizenz verfügbar sind, schwerfällt. Besonders im Sinne der Individualisierung des Unterrichts und der Differenzierung von Materialien zeigt sich, dass Lehrpersonen Dateiformate präferieren, die eine einfache Adaptierung der gefundenen Materialien erlauben. In Bezug auf die Verfügbarkeit von Materialien geht der klare Wunsch nach einem Ausbau des Materialangebots sowie bereits bestehender Materialien hervor. Als Lösungsvorschlag wurde einerseits der Ausbau einer bereits bestehenden Plattform genannt und andererseits die Etablierung einer neuen, umfangreicheren und übersichtlichen Plattform.

Abstract
The concept of Open Educational Resources was developed in the context of higher education, but it is increasingly being used in other areas of education, especially in schools. The present study investigates the knowledge of Austrian teachers concerning Open Educational Resources, how they use them in inclusive education and what their wishes and needs are with regard to this topic, both in terms of training and further education, as well as regarding using Open Educational Resources in classrooms. Eleven Austrian teachers were interviewed with a semi-standardised guideline in spring/summer 2022. The majority of the interviewees had no or hardly any previous contact with the term OER. Nevertheless, each of the eleven teachers regularly uses OER in their teaching, even if the differentiation between OER and materials not available under a free licence is difficult for them. Especially regarding individualisation of teaching and differentiation of materials teachers prefer file formats allowing an easy adaptation of the materials. Regarding the availability of materials, there is a clear desire to expand the range of existing materials. The proposed solution was on the one hand the extension of an existing platform and on the other hand the establishment of a new, more comprehensive and clearly structured platform for OER.
Apoptotic Switch in Cancer Stem Cells: A Potential Approach for Cancer Treatment
Authors: Gunasekaran Vinoth Prasanna , Sivaraman Thirunavukkarasu , Ganeshan Mathan 
Published: May 2023

Abstract:Cancer diseases account for about 15% of deaths globally right now, and the percentage may increase in the future. There are more than 100 types of cancer, and each of them is distinct in its origin, microenvironment, growth, metastasis, and signalling pathways. Cancer stem cells are the specialised cells that make cancer more aggressive and difficult to treat. Moreover, cancer aetiology may exist at the genomic, proteomic, or habitat level in any combination. Hence, a unanimous treatment protocol for the different cancers is an uphill task at the present juncture. In this context, this review aims to provide a comprehensive reappraisal concisely of anti-apoptotic proteins, which are shown to be overexpressed in most cancers, if not all, and to forthrightly rationalise the apoptotic proteins as potential biomarkers and druggable targets of the cancers by effectively killing cancer stem cells.
Protective Effects of Propolis on Behavioral and Stress Oxidative Changes
in Cuprizone-Induced Demyelination Model
Authors: Farhadifard Ghazal , Haddadi Rasool , Sanemar Khashayar , Farhadifard Homa , Mohammadi Mojdeh 
Published: May 2023

Objective:
Multiple sclerosis (MS) is a continuing demyelination inflammatory disease of
the central nervous system (CNS). In this study, we investigated the effect of propolis on locomotor
coordination and stress oxidative modifications in the demyelination model induced by cuprizone because
of its antioxidant, neuroprotective, and anti-inflammatory properties.

Methods:
Mice were nourished with powdered chow, including 0.4% w/w cuprizone for one week and
then 0.2% w/w cuprizone for four weeks, for MS induction. Mice were given propolis at various doses
(100,150, and 200 mg/kg of body weight) during the last 4-weeks of treatment with cuprizone.

Results:
Based on our results, the number of falls decreased significantly in 150 mg/kg and 200 mg/kg
propolis+cuprizone groups (p < 0.001) but, no significant difference was reported between the 100
mg/kg propolis+cuprizone group and the cuprizone group. The malondialdehyde level decreased significantly
in 150 mg/kg and 200 mg/kg propolis+cuprizone (p < 0.01, p < 0.001, respectively), although
there was no significant difference in the 100 mg/kg propolis+cuprizone compared to cuprizone
group. Glutathione levels increased significantly in 150 mg/kg and 200 mg/kg propolis+cuprizone
groups (p < 0.05, p < 0.001, respectively) compared to the cuprizone group. There was no noteworthy
difference in glutathione level at the 100 mg/kg propolis+cuprizone concentration as compared to the
cuprizone group.

Conclusion:
Propolis has the potential to be used as an adjunctive drug in multiple sclerosis treatment.
Part Two: Neural Network Controller for Hydrogen-CNG Powered Vehicle
Authors: Kale Amar , Kadri Usman , Kamble Jayesh , Thorat Makarand , Vijayan Pallippattu , Badgujar Kushal , Kharade Prakash 
Published: May 2023

Background:
The control system of the vehicle regulates parameters like fuel flow
control, vehicle speed control, tracking, etc.

Objective:
The main objective of the paper is to monitor and determine an efficient, and automated
control system for an H-CNG-powered vehicle. Using neural networks and machine learning, we
would develop an algorithm for the controller to regulate the speed of the car with the help of
variables involved during the runtime of the vehicle.

Methods:
Initially, Generating a dataset with the help of formulation and computation for training.
Further, analysing different supervised machine learning algorithms and training the Artificial
Neural Network (ANN) using the generated dataset to predict and track the gains of the H-CNG
vehicle accurately.

Results:
Analysis of the gains of the H-CNG vehicle are presented to understand the precision of the
trained Neural Network.

Conclusion:
The final verdict of the paper is that the Neural Network is successful in tracking the
gains of the H-CNG vehicle with the help of the dataset presented for training using the Random
Forest Regression technique for machine learning.
Artificial Intelligence in Health Care—Understanding Patient Information Needs and Designing Comprehensible Transparency: Qualitative Study
Authors: Robinson Renee , Liday Cara , Lee Sarah , Williams Ishan C , Wright Melanie , An Sungjoon , Nguyen Elaine 
Published: May 2023

Background
Artificial intelligence (AI) is a branch of computer science that uses advanced computational methods, such as machine learning (ML), to calculate and predict health outcomes and address patient and provider health needs. While these technologies show great promise for improving health care, especially in diabetes management, there are usability and safety concerns for both patients and providers about the use of AI/ML in health care management.

Objective
We aimed to support and ensure safe use of AI/ML technologies in health care; thus, the team worked to better understand (1) patient information and training needs, (2) the factors that influence patients’ perceived value and trust in AI/ML health care applications, and (3) how best to support safe and appropriate use of AI/ML-enabled devices and applications among people living with diabetes.

Methods
To understand general patient perspectives and information needs related to the use of AI/ML in health care, we conducted a series of focus groups (n=9) and interviews (n=3) with patients (n=41) and interviews with providers (n=6) in Alaska, Idaho, and Virginia. Grounded theory guided data gathering, synthesis, and analysis. Thematic content and constant comparison analysis were used to identify relevant themes and subthemes. Inductive approaches were used to link data to key concepts, including preferred patient-provider interactions and patient perceptions of trust, accuracy, value, assurances, and information transparency.

Results
Key summary themes and recommendations focused on (1) patient preferences for AI/ML-enabled device and application information, (2) patient and provider AI/ML-related device and application training needs, (3) factors contributing to patient and provider trust in AI/ML-enabled devices and applications, and (4) AI/ML-related device and application functionality and safety considerations. A number of participants (patients and providers) made recommendations to improve device functionality to guide information and labeling mandates (eg, link to online video resources and provide access to 24/7 live in-person or virtual emergency support). Other patient recommendations included (1) providing access to practice devices, (2) providing connections to local supports and reputable community resources, and (3) simplifying the display and alert limits.

Conclusions
Recommendations from both patients and providers could be used by federal oversight agencies to improve utilization of AI/ML monitoring of technology use in diabetes, improving device safety and efficacy.
Perancangan UI/UX My Seven Berbasis Mobile Dengan Metode User Centered Design (UCD)
Authors: Pudjayadi Rama , Al Hakim Shidiq 
Published: May 2023

Pada era digital saat ini, sistem pendidikan di indonesia perlu terus didorong untuk beradaptasi terhadap teknologi. Dalam rangka adapatasi pada kebutuhan teknologi, terutama keniscayaan yang muncul karena pandemi COVID-19, sistem informasi yang terintegrasi dengan pembelajaran pada sekolah diperlukan untuk kelancaran proses pengajaran dan administrasi pendidikan. Oleh karena itu peneliti melakukan perancangan prototype berupa aplikasi informasi akademik pada tingkat SMK. Penelitian ini menggunakan metode User Centered Desain (UCD), untuk dapat menghasilkan prototipe yang sesuai dengan harapan penggunanya. Melalui wawancara langsung kepada beberapa guru, murid dan tenaga administrasi, kemudian menganalisis dan membuatkan desain prototipe high fidelity yang dibutuhkan oleh pengguna. Untuk memastikan kesesuaian harapan pengguna dengan hasil desain, pada penelitian ini menguji prototipenya dengan instrument System Usability Design (SUS). Hasil dari pengujian diperoleh skor rata-rata dengan skor 74,4, hal ini menunjukan rancangan desain aplikasi MY SEVEN sebagai aplikasi sistem informasi akademik pada SMK sudah cukup baik untuk dapat dikembangkan aplikasinya dan diterapkan di sekolah.
¿Los niños nacidos prematuros presentarán dificultades al momento de su inclusión educativa?
Authors: Dalbes Mariana 
Published: May 2023

El presente artículo pretende compartir la inquietud sobre la inclusión en el ámbito escolar de los niños que nacieron con desventajas desde lo biológico dada su prematurez. Estos niños que nacen prematuros, por su inmadurez, sufren una serie de patologías que requieren cuidados especiales en los servicios de neonatología y un seguimiento posterior, a cargo de un equipo interdisciplinario de profesionales, para lograr minimizar sus secuelas y desarrollar plenamente sus capacidades.
Los bebés prematuros y de bajo peso presentan, en comparación con los nacidos a término, una serie de características que los colocan en situación de alto riesgo. Además, se trata de indagar si requirieron apoyos, si recibieron asistencia terapéutica, si la familia los acompañó en este proceso y en el arribo a la etapa escolar, para poner en evidencia si presentaron dificultades en su incorporación a la escuela (como dificultades en los aprendizajes de lectoescritura, por ejemplo).
PERENCANAAN SPAM PERDESAAN PEKON TANJUNG REJO KECAMATAN BANGKUNAT KABUPATEN PESISIR BARAT
Authors: Fitriansyah Herwan 
Published: May 2023

Air Minum merupakan kebutuhan dasar dan hak bagi semua warga negara yang menjadi kewajiban oleh pemerintah pusat maupun pemerintah daerah untuk memenuhinya. Dengan semakin meningkatnya jumlah penduduk maka kebutuhan akan air minum akan terus meningkat. Pada saat ini pelayanan Sistem Penyediaan Air Minum (SPAM) di Kabupaten Pesisir Barat terdiri dari SPAM Perkotaan (dan SPAM Perdesaan, yang ada hanya dapat melayani konsumen sebesar 15,15% (Review RISPAM 2021) dari jumlah penduduk yang ada. Tingkat layanan air minum di Pekon Tanjung Rejo Kecamatan Bangkunat Kabupaten Pesisir Barat pada saat ini hanya mencapai 10%, Hal ini disebabkan oleh berkurangnya debit air dari sumber mata air. kerusakan dan kebocoran jaringan serta penyumbatan pipa akibat sedimentasi pada SPAM eksisting. Dengan jumlah penduduk pada tahun 2021 sebanyak 2.755 jiwa, maka diproyeksikan jumlah penduduk di Pekon Tanjung rejo pada tahun 2041 adalah 3.678. Direncanakan pembangunan SPAM Pekon Tanjung Rejo dengan system gravitasi mengambil sumber air baku Sungai Way Pintau (Debit 3,5 m3/det), dengan debit rencana yang sebanyak 5 l/detik dapat melayani sampai 20 tahun dengan tingkat layanan 80% (2.942 jiwa).
Investigasi Permasalahan High Pressure Pada Pekerjaan Jacking Pipe 450 ( Studi Kasus Proyek Ipal Palembang Paket B2 A)
Authors: Fauzi Even Ahmad , Purba Aleksander , Widyawati Ratna 
Published: May 2023

Metode yang digunakan dalam pelaksanaan pemasangan pipa jaringan tersebut menjadi dua yaitu metode trenchless (galian tertutup) dan metode open trench (galian terbuka). Untuk metode trenchless yang digunakan adalah slurry jacking untuk pemasangan pipa RCP 450mm. Permasalahan saat terjadi saat pekerjaan pemasangan pipa RCP 450mm dengan metode auger drilling jacking. Dari total 9 trase yang akan dikerjakan terdapat 1 trase yang berada di lapisan tanah keras yaitu trase MH 1000 ke MH 1002 dengan panjang 75.6 meter. Mesin yang digunakan adalah mesin dari Jerman merek Bohrtec BM 400s ternyata terjadi high pressure. Ini terlihat dari tekanan tinggi pada mesin Auger Drilling Jacking pada saat pelaksanaan pekerjaan awal atau piloting works. Di dapatkan nilai pressure push mencapai 200 bar sehingga tahapan dalam pekerjaan jacking dengan mesin Auger Drilling BM. 400 tidak dapat dilanjutkan. Dampak yang terjadi akibat kondisi tersebut tentunya pembengkakan biaya proyek dan keterlambatan penyelesaian proyek. Studi kasus ini bertujuan untuk menemukan solusi dari penyebab permasalahan high pressure push pada pekerjaan jacking pipe. Analisa dilakukan pada kasus high pressure yang terjadi dengan mempelajari literasi atau penelitian sejenis kemudian dilakukan identifikasi penyebab terjadinya high pressure. Kemudian, beberapa metode yang telah dicoba dianalisis mendalam. Hasilnya menunjukkan jika penyebab high pressure dipengaruhi oleh beberapa faktor yaitu karakteristik tanah dan panjang trase/span . Langkah metode yang dapat dilakukan untuk meminimalisir dan penanganan high pressure yaitu dengan melakukan temporary pit, dengan memperpendek trase/span. Pada kondisi tanah yang dominan clay keras, direkomendasikan penggunaan temporary pit dengan steel sheet pile sebagai temporary pit di tengah trase sebagai langkah preventif. Sedangkan penggunaan metode steel sheet pile bersifat temporary.