bluuebunny/crossref_metadata_2025_split huggingface dataset:
At-Risk Tackling Techniques and Effectiveness in NCAA Division I Collegiate Football
Authors: Hirase Takashi , Bondar Kevin , Doucet Dakota , Moore Brady , Saifi Comron , Marco Rex A.W. 
Published: July 2023

Background: Head-down tackling has been associated with injuries to the brachial plexus, cervical spine, and head in high school and collegiate American football. Head-down tackling has also been associated with decreased effectiveness in successful tackles compared with head-up tackling. Purpose: To assess tackling techniques used during National Collegiate Athletic Association (NCAA) Division I football games and to evaluate the successful tackling rates according to technique. Study Design: Cross-sectional study. Methods: Three reviewers analyzed 1000 consecutive solo defensive tackling attempts made in the 2021 season (October to December) by 8 universities within the NCAA Southeastern Conference. Slow-motion replays were used to analyze the success of the tackling attempt, the tackling method, and the initial point of contact with respect to the offensive player’s waist. The chi-square or Fisher exact test was used to analyze categorical data, and the 2-tailed Student t-test or the Mann-Whitney U test was used to analyze continuous data. Results: Head-up and head-down tackling occurred in 902 (90.2%) and 98 (9.8%) tackle attempts, respectively. Head-up tackles were successful in 76.2% of the attempts compared with 55.1% for head-down tackles ( P < .001). Tackles were made at or above the offensive player’s waist in 777 (77.7%) attempts and below the waist in 223 (22.3%) attempts. Tackles at or above the waist were successful in 77.6% of the attempts compared with 61.9% of tackles below the waist ( P < .001). The inside-shoulder method was used in 592 (59.2%) tackles, the arm method in 317 (31.7%), the head-across-the-bow method in 72 (7.2%), and the helmet-to-helmet method in 19 (1.9%). Inside-shoulder tackles had the highest success rate of 93.2%, compared with 41.6% for arm ( P < .001), 59.7% for head-across-the-bow ( P < .001), and 73.7% for helmet-to-helmet ( P = .001) tackles. Inside-shoulder tackles resulted in head-up tackling in 92.9% compared with 41.7% for head-across-the-bow ( P < .001) and 57.9% for helmet-to-helmet ( P < .001) tackles. There were no recorded injuries to the tackler. Conclusion: Head-up tackles, tackles made at or above the offensive player’s waist, and inside-shoulder tackles had the highest success rates. Head-down tackling and tackling below the waist were associated with poor tackling methods, including head-across-the-bow and helmet-to-helmet tackles, which had lower success rates.
A Wire-Driven Series Elastic Mechanism Based on Ultrasonic Motor for Walking Assistive System
Authors: Ren Weihao , Yoshioka Hiroki , Yang Lin , Morita Takeshi 
Published: July 2023

AbstractIn order to improve the elderly people’s quality of life, supporting their walking behaviors is a promising technology. Therefore, based on one ultrasonic motor, a wire-driven series elastic mechanism for walking assistive system is proposed and investigated in this research. In contrast to tradition, it innovatively utilizes an ultrasonic motor and a wire-driven series elastic mechanism to achieve superior system performances in aspects of simple structure, high torque/weight ratio, quiet operation, quick response, favorable electromagnetic compatibility, strong shock resistance, better safety, and accurately stable force control. The proposed device is mainly composed of an ultrasonic motor, a linear spring, a steel wire, four pulleys and one rotating part. To overcome the ultrasonic motor’s insufficient output torque, a steel wire and pulleys are smartly combined to directly magnify the torque instead of using a conventional gear reducer. Among the pulleys, there is one tailored pulley playing an important role to keep the reduction ratio as 4.5 constantly. Meanwhile, the prototype is manufactured and its actual performance is verified by experimental results. In a one-second operating cycle, it only takes 86 ms for this mechanism to output an assistive torque of 1.6 N·m. At this torque, the ultrasonic motor’s speed is around 4.1 rad/s. Moreover, experiments with different operation periods have been conducted for different application scenarios. This study provides a useful idea for the application of ultrasonic motor in walking assistance system.
Genomic virulence features of Beauveria bassiana as a biocontrol agent for the mountain pine beetle population
Authors: Li Janet X. , Fernandez Kleinberg X. , Ritland Carol , Jancsik Sharon , Engelhardt Daniel B. , Coombe Lauren , Warren René L. , van Belkum Marco J. , Carroll Allan L. , Vederas John C. , Bohlmann Joerg , Birol Inanc 
Published: July 2023

Abstract
Background
The mountain pine beetle, Dendroctonus ponderosae, is an irruptive bark beetle that causes extensive mortality to many pine species within the forests of western North America. Driven by climate change and wildfire suppression, a recent mountain pine beetle (MPB) outbreak has spread across more than 18 million hectares, including areas to the east of the Rocky Mountains that comprise populations and species of pines not previously affected. Despite its impacts, there are few tactics available to control MPB populations. Beauveria bassiana is an entomopathogenic fungus used as a biological agent in agriculture and forestry and has potential as a management tactic for the mountain pine beetle population. This work investigates the phenotypic and genomic variation between B. bassiana strains to identify optimal strains against a specific insect.

Results
Using comparative genome and transcriptome analyses of eight B. bassiana isolates, we have identified the genetic basis of virulence, which includes oosporein production. Genes unique to the more virulent strains included functions in biosynthesis of mycotoxins, membrane transporters, and transcription factors. Significant differential expression of genes related to virulence, transmembrane transport, and stress response was identified between the different strains, as well as up to nine-fold upregulation of genes involved in the biosynthesis of oosporein. Differential correlation analysis revealed transcription factors that may be involved in regulating oosporein production.

Conclusion
This study provides a foundation for the selection and/or engineering of the most effective strain of B. bassiana for the biological control of mountain pine beetle and other insect pests populations.
XGBoost-based machine learning test improves the accuracy of hemorrhage prediction among geriatric patients with long-term administration of rivaroxaban
Authors: Chen Cheng , Yin Chun , Wang Yanhu , Zeng Jing , Wang Shuili , Bao Yurong , Xu Yixuan , Liu Tongbo , Fan Jiao , Liu Xian 
Published: July 2023

Abstract
Background
Hemorrhage is a potential and serious adverse drug reaction, especially for geriatric patients with long-term administration of rivaroxaban. It is essential to establish an effective model for predicting bleeding events, which could improve the safety of rivaroxaban use in clinical practice.

Methods
The hemorrhage information of 798 geriatric patients (over the age of 70 years) who needed long-term administration of rivaroxaban for anticoagulation therapy was constantly tracked and recorded through a well-established clinical follow-up system. Relying on the 27 collected clinical indicators of these patients, conventional logistic regression analysis, random forest and XGBoost-based machine learning approaches were applied to analyze the hemorrhagic risk factors and establish the corresponding prediction models. Furthermore, the performance of the models was tested and compared by the area under curve (AUC) of the receiver operating characteristic (ROC) curve.

Results
A total of 112 patients (14.0%) had bleeding adverse events after treatment with rivaroxaban for more than 3 months. Among them, 96 patients had gastrointestinal and intracranial hemorrhage during treatment, which accounted for 83.18% of the total hemorrhagic events. The logistic regression, random forest and XGBoost models were established with AUCs of 0.679, 0.672 and 0.776, respectively. The XGBoost model showed the best predictive performance in terms of discrimination, accuracy and calibration among all the models.

Conclusion
An XGBoost-based model with good discrimination and accuracy was built to predict the hemorrhage risk of rivaroxaban, which will facilitate individualized treatment for geriatric patients.
Does COVID-19 vaccine exacerbate rotator cuff symptoms? A prospective study
Authors: İğrek Servet , Ulusoy İbrahim , Çeliksöz Aytek Hüseyin 
Published: July 2023

Abstract
Background
Shoulder injury related to vaccine administration (SIRVA) is a rare but increasing complication after vaccination. The aim of this study was to increase awareness of post-vaccination shoulder pain and to investigate the effect of the clinical condition of the shoulder before vaccination on the loss of function that may occur after vaccination.

Methods
This prospective study included 65 patients aged > 18 years who were diagnosed with unilateral shoulder impingement and/or bursitis. The first vaccination was performed on the shoulders with rotator cuff symptoms, then the second vaccination was performed on healthy shoulders of same patients as soon as the health system allowed. Pre-vaccination MRI of the symptomatic shoulders of the patients was performed and VAS, ASES and Constant scores were evaluated. At 2 weeks after vaccination of the symptomatic shoulder, scores were reassessed. For the patients with changes in the scores, MRI was performed again and the treatment of all patients was started. A second vaccination was given to asymptomatic shoulders and the patients were recalled two weeks later and their scores were evaluated.

Results
After vaccination, the symptomatic shoulder of 14 patients was affected. No clinical changes were observed in the asymptomatic shoulders after vaccination. The VAS scores of the symptomatic shoulders evaluated after vaccination were significantly higher than the scores evaluated before vaccination (p = 0.001). The ASES and Constant scores of symptomatic shoulders evaluated after vaccination were significantly decreased compared to the scores evaluated before vaccination (p = 0.001).

Conclusions
Exacerbation of symptoms may occur if symptomatic shoulders are vaccinated. Before vaccination, a detailed anamnesis should be taken from the patients and vaccination should be performed to the asymptomatic side.
Development of a nomogram model for prediction of new adjacent vertebral compression fractures after vertebroplasty
Authors: Qian Yadong , Hu Xiao , Li Chen , Zhao Jingwei , Zhu Yanjing , Yu Yan , Xie Ning , Ma Bin , Zeng Zhili , Cheng Liming 
Published: July 2023

Abstract
Background
Vertebroplasty is the main minimally invasive operation for osteoporotic vertebral compression fracture (OVCF), which has the advantages of rapid pain relief and shorter recovery time. However, new adjacent vertebral compression fracture (AVCF) occurs frequently after vertebroplasty. The purpose of this study was to investigate the risk factors of AVCF and establish a clinical prediction model.

Methods
We retrospectively collected the clinical data of patients who underwent vertebroplasty in our hospital from June 2018 to December 2019. The patients were divided into a non-refracture group (289 cases) and a refracture group (43 cases) according to the occurrence of AVCF. The independent predictive factors for postoperative new AVCF were determined by univariate analysis, least absolute shrinkage and selection operator (LASSO) logistic regression, and multivariable logistic regression analysis. A nomogram clinical prediction model was established based on relevant risk factors, and the receiver operating characteristic curve (ROC), calibration curve, and decision curve analysis (DCA) were used to evaluate the prediction effect and clinical value of the model. After internal validation, patients who underwent vertebroplasty in our hospital from January 2020 to December 2020, including a non-refracture group (156 cases) and a refracture group (21 cases), were included as the validation cohort to evaluate the prediction model again.

Results
Three independent risk factors of low bone mass density (BMD), leakage of bone cement and “O” shaped distribution of bone cement were screened out by LASSO regression and logistic regression analysis. The area under the curve (AUC) of the model in the training cohort and the validation cohort was 0.848 (95%CI: 0.786–0.909) and 0.867 (95%CI: 0.796–0.939), respectively, showing good predictive ability. The calibration curves showed the correlation between prediction and actual status. The DCA showed that the prediction model was clinically useful within the whole threshold range.

Conclusion
Low BMD, leakage of bone cement and “O” shaped distribution of bone cement are independent risk factors for AVCF after vertebroplasty. The nomogram prediction model has good predictive ability and clinical benefit.
MiR-183-5p promotes migration and invasion of prostate cancer by targeting TET1
Authors: Feng Yuehua , Wang Kai , Qin Minchao , Zhuang Qianfeng , Chen Zhen 
Published: July 2023

Abstract
Background
Prostate cancer (PCa) is one of the common malignant tumors worldwide. MiR-183-5p has been reported involved in the initiation of human PCa, this study aimed to investigate whether miR-183-5p affects the development of prostate cancer.

Methods
In this study, we analyzed the expression of miR-183-5p in PCa patients and its correlation with clinicopathological parameters based on TCGA data portal. CCK-8, migration assay and invasion and wound-healing assay were performed to detect proliferation, migration and invasion in PCa cells.

Results
We found the expression of miR-183-5p was significantly increased in PCa tissues, and high expression of miR-183 was positively associated with poor prognosis of PCa patients. Over-expression of miR-183-5p promoted the migration, invasion capacities of PCa cells, whereas knockdown of miR-183-5p showed reversed function. Furthermore, luciferase reporter assay showed TET1 was identified as a direct target of miR-183-5p, which was negatively correlation with miR-183-5p expression level. Importantly, rescue experiments demonstrated TET1 over-expression could reverse miR-183-5p mimic induced-acceleration of PCa malignant progression.

Conclusion
Our results indicated that miR-183-5p could act as a tumor promoter in PCa and it accelerated the malignant progression of PCa by directly targeting and down-regulating TET1.
Pheochromocytoma crisis with refractory Acute Respiratory Distress Syndrome (ARDS), Takotsubo syndrome, emergency adrenalectomy, and need for Extracorporeal Membrane Oxygenation (ECMO) in a previously undiagnosed and asymptomatic patient, due to the use of metoclopramide
Authors: Xie Yuhua , Zhang An , Qi Min , Xiong Bin , Zhang Suhua , Zhou Jianzhong , Cao Yunxing 
Published: July 2023

Abstract
Background
Pheochromocytoma (PCC) crisis is a rare life-threatening endocrine emergency. The diagnosis and treatment of PCC crisis, with acute respiratory distress syndrome (ARDS) as the first manifestation, is highly challenging, and traditional PCC management strategies are no longer suitable for these patients.

Case presentation
A 46-year-old female patient was admitted to the Intensive Care Unit (ICU) following sudden-onset acute respiratory distress and subsequent initiation of mechanical ventilation via endotracheal intubation. She was initially suspected of having a PCC crisis through the bedside critical care ultrasonic examination protocol. The computed tomography examination revealed a left adrenal neoplasm of 6.5cm × 5.9cm. The plasma-free metanephrine level was 100 times higher than the reference value. These findings were compatible with her PCC diagnosis. Alpha-blockers and fluid intake were started immediately. The endotracheal intubation was removed on the 11th day after admission to the ICU. The patient progressed to severe ARDS again, and invasive ventilation and continuous renal replacement therapy were needed. Despite aggressive therapy, her condition deteriorated. Therefore, she underwent veno-arterial extracorporeal membrane oxygenation (VA-ECMO)-assisted emergency adrenalectomy after multidisciplinary discussion. Postoperatively, the patient was supported by VA-ECMO for 7days. She was discharged from the hospital on day 30 after tumor resection.

Conclusions
This case highlighted the challenges in diagnosing and managing ARDS associated with PCC crisis. The traditional preoperative preparation protocol and optimal operation timing for patients with PCC are not suitable for patients with PCC crisis. Patients with life-threatening PCC crisis may benefit from early tumor removal, and VA-ECMO could maintain hemodynamic stability during and after surgery.
Knowledge, attitude, and associated factor towards cervical cancer prevention among primary and secondary school female teachers in Gondar town, North West Ethiopia, 2022
Authors: Negash Birtukan Atena , Bayu Netsanet Habtie , Woretaw Ashenafi Worku 
Published: July 2023

Abstract
Introduction
Cervical cancer is uncontrolled proliferation of cells on the cervix. Worldwide, millions of women suffer from this disease. Cervical cancer can be prevented by increasing awareness and changing negative attitude about the cause and prevention of cervical cancer. The aim of this study was to identify the gap of knowledge, attitude and associated factor about cervical cancer prevention.

Method
Institution-based cross-sectional study was conducted to collect data from 633 female teachers who were working in primary and secondary schools in Gondar town by using a stratified sampling technique. The collected data were checked for any inconsistency, coded, and entered by using EPI INFO version 7 and analyzed by using SPSS version 25. Both Bivariable and multivariable logistic regression analysis was computed to identify the association between the dependent variable with independent variables. Variables having P-value < 0.05 were considered statistically significant.

Result
The response rate of this study was 96.4% (610). Of these 38.4% (95% CI; 34.49–42.23) and 56.2% (95% CI; 52.28–60.18) of teachers had good knowledge and positive attitude on cervical cancer prevention respectively. Factors affecting teachers knowledge level were studied language [AOR; 3.9; (1.509–10.122)], Natural Science [AOR 2.9;( 1.128–7.475)], being married [AOR: 0.386; [95% (0.188–0.792)], and heard information from health professionals [AOR; 0.53(0.311–0.925)]. Working in secondary school [AOR; 1.83(1.03–3.25)], have regular menstrual period [AOR; 2.32(1.49–3.62)], no history of abortion, (AOR; 0.45(0.23–0.89), and good knowledge status (AOR, 2.56(1.64–4.00) were significantly associated with positive attitude.

Conclusion
Most of teacher’s knowledge and attitude regarding to cervical cancer prevention were poor. Being married, the field of study, and natural science, heard information from health professionals were factors associated with knowledge. Working in secondary school, having regular menstrual period, no history of abortion, and good knowledge were factors associated attitude regarding to cervical cancer prevention. Therefore, enhancing health promotion through mass media and established counseling program with reproductive health is important.
Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia
Authors: Cui Long-Biao , Wang Xian-Yang , Fu Yu-Fei , Liu Xiao-Fan , Wei Yongbin , Zhao Shu-Wan , Gu Yue-Wen , Fan Jing-Wen , Wu Wen-Jun , Gong Hengfen , Lin Bochao Danae , Yin Hong , Guan Fanglin , Chang Xiao 
Published: July 2023

Abstract
Background
Inflammation has been implicated in the pathology of schizophrenia and may cause neuronal cell death and dendrite loss. Neuroimaging studies have highlighted longitudinal brain structural changes in patients with schizophrenia, yet it is unclear whether this is related to inflammation. We aim to address this question, by relating brain structural changes with the transcriptional profile of inflammation markers in the early stage of schizophrenia.

Methods
Thirty-eight patients with first-episode schizophrenia and 51 healthy controls were included. High-resolution T1-weighted magnetic resonance imaging (MRI) and clinical assessments were performed at baseline and 2 ~ 6 months follow-up for all subjects. Changes in the brain structure were analyzed using surface-based morphological analysis and correlated with the expression of immune cells-related gene sets of interest reported by previous reviews. Transcriptional data were retrieved from the Allen Human Brain Atlas. Furthermore, we examined the brain structural changes and peripheral inflammation markers in association with behavioral symptoms and cognitive functioning in patients.

Results
Patients exhibited accelerated cortical thickness decrease in the left frontal cortices, less decrease or an increase in the superior parietal lobule and right lateral occipital lobe, and increased volume in the bilateral pallidum, compared with controls. Changes in cortical thickness correlated with the transcriptional level of monocyte across cortical regions in patients (r = 0.54, p < 0.01), but not in controls (r =  − 0.05, p = 0.76). In addition, cortical thickness change in the left superior parietal lobule positively correlated with changes in digital span-backward test scores in patients.

Conclusions
Patients with schizophrenia exhibit regional-specific cortical thickness changes in the prefrontal and parietooccipital cortices, which is related to their cognitive impairment. Inflammation may be an important factor contributing to cortical thinning in first-episode schizophrenia. Our findings suggest that the immunity-brain-behavior association may play a crucial role in the pathogenesis of schizophrenia.