bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the German version of the Short Health Scale – a brief, valid and reliable instrument to assess health-related quality of life in German-speaking patients with inflammatory bowel diseases
Authors: Demmer Sina , Kleindienst Nikolaus , Hjortswang Henrik , Thomann Philipp , Ebert Matthias , Reindl Wolfgang , Thomann Anne 
Published: June 2023

Abstract
Background Health-related quality of life (hrQoL) may be the most important patient-reported outcome for patients with chronic disorders. The Short Health Scale (SHS) is a brief four-item instrument to assess hrQoL in patients with bowel disorders. This study examined the validity, reliability and sensitivity of the German translation of the SHS in a cohort of outpatients with inflammatory bowel diseases (IBD).
Methods The study was preregistered in April 2021 (https://doi.org/10.17605/OSF.IO/S82D9). Outpatients with IBD (n=225) in different stages of disease activity (as determined by the Harvey–Bradshaw index or partial Mayo score) completed the German SHS and the short Inflammatory Bowel Disease Questionnaire (sIBDQ) as an established measure of hrQoL to examine the convergent validity. To assess reliability, a subset of patients (n=30) in remission completed the same questionnaires after 4–8 weeks. Sensitivity to change was established from questionnaires of patients with either decreased (n=15) or increased (n=16) disease activity after 3–6 months.
Results The internal consistency of the German SHS was high (Cronbach’s α=0.860). SHS total scores correlated strongly with sIBDQ scores (ρ=–0.760, p<0.001) and disease activity (ρ=0.590, p<0.001). Retest reliability was high (ρ=0.695, p<0.001). Sensitivity to change was statistically significant for patients with decreased (p=0.013) but not increased (p=0.134) disease activity.
Conclusion The German version of the SHS is a valid and reliable tool to measure hrQoL in persons with IBD.
Interdisziplinäre Adipositas-Therapie
Authors: Walle Hardy 
Published: June 2023

ZusammenfassungAdipositas und Diabetes mellitus Typ 2 sind in Deutschland an der Tagesordnung und weiter auf dem Vormarsch. Bei leichtem Übergewicht ist die klassische Ernährungstherapie hilfreich, ab einem BMI von 40 bzw. 50 kg/m2 ist die bariatrische Chirurgie indiziert. Studien konnten belegen, dass sich für die Gruppe der Patient*innen mit dazwischenliegenden BMI-Werten Formula- oder Mahlzeitenersatzprogramme eignen. Der Beitrag stellt das Bodymed-Konzept vor, das als fachübergreifendes, patientenspezifisches und individualisiertes Therapieangebot gilt. In Deutschland gibt es über 1000 Bodymed-Zentren, die die Gewichtsabnahme therapeutisch begleiten. Reine Abnehm-Apps sind zu wenig, daher setzt dieses Modell auf eine hybride Lösung, wodurch die Beratung wohnortnah stattfinden kann, individueller wird und damit erfolgreicher ist.
Prophylactic Tranexamic Acid Prevents Postpartum Hemorrhage and Transfusions in Cesarean Deliveries: A Systematic Review and Meta-analysis
Authors: Lee Amy , Wang Mary Ying-Fang , Roy Debosree , Wang Jenny , Gokhale Abha , Miranda-Cacdac Lauren , Kuntz Moriah , Grover Bryan , Gray Kendra , Curley Kathleen L. 
Published: June 2023

Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide and PPH resulting in transfusion is the most common maternal morbidity in the United States. Literature demonstrates that tranexamic acid (TXA) can reduce blood loss in cesarean deliveries; however, there is little consensus on the impact on major morbidities like PPH and transfusions. We conducted a systematic review/meta-analysis of randomized controlled trials (RCTs) to evaluate if administration of prophylactic intravenous (IV) TXA prevents PPH and/or transfusions following low-risk cesarean delivery. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines were followed. Five databases were searched: Cochrane, EBSCO, Ovid, PubMed, and ClinicalKey. RCTs published in English between January 2000 and December 2021 were included. Studies compared PPH and transfusions in cesarean deliveries between prophylactic IV TXA and control (placebo or no placebo). The primary outcome was PPH, and the secondary outcome was transfusions. Random effects models were used to calculate effect size (ES) of exposure in Mantel–Haenszel risk ratios (RR). All analysis was done at a confidence level (CI) of α = 0.5. Modeling showed that TXA led to significantly less risk of PPH than control (RR: 0.43; 95% CI: 0.28–0.67). The effect on transfusion was comparable (RR: 0.39; 95% CI: 0.21–0.73). Heterogeneity was minimal (I
2 = 0%). Due to the large sample sizes needed, many RCTs are not powered to interpret TXA's effect on PPH and transfusions. Pooling these studies in a meta-analysis allows for more power and analysis but is limited by the heterogeneity of studies. Our results minimize heterogeneity while demonstrating that prophylactic TXA can lower PPH occurrence and reduce the need for blood transfusion. We suggest considering prophylactic IV TXA as the standard of care in low-risk cesarean deliveries.
Key Points
Basal Plate Myofibers and the Risk of Placenta Accreta Spectrum in the Subsequent Pregnancy: A Large Single-Center Cohort
Authors: Erfani Hadi , Hessami Kamran , Salmanian Bahram , Castro Eumenia C. , Kopkin Rachel , Hecht Jonathan L. , Gogia Soumya , Jackson Josef N. , Dong Elaine , Fox Karin A. , Gessner McKenna , Fang Mary E. , Shainker Scott A. , Baroni Mariana D. , Modest Anna M. , Shamshirsaz Amir A. , Nassr Ahmed A. , Espinoza Jimmy , Aagaard Kjersti M. , Shamshirsaz Alireza A. 
Published: June 2023

Objective We aimed to evaluate whether there is a significant association between a placental pathology diagnosis basal plate myofibers (BPMF) in an index pregnancy with placenta accreta spectrum (PAS) in the subsequent pregnancy.
Study Design We conducted a retrospective nested cohort study of all cases with a histopathological finding of BPMF between August 2012 and March 2020 at a single tertiary referral center. Data were collected for all subjects (cases and controls) with at least two consecutive pregnancies (the initial index pregnancy and at least one subsequent pregnancy) accompanied by a concomitant record of histopathological study of the placenta at our center. The primary outcome was pathologically confirmed PAS in the subsequent pregnancy. Data are presented as percentage or median, interquartile range accordingly.
Results A total of n = 1,344 participants were included, of which n = 119 (index cases) carried a contemporaneous histopathological diagnosis of BPMF during the index pregnancy and n = 1,225 did not (index controls). Among the index cases, patients with BPMF were older (31.0 [20, 42] vs. 29.0 [15, 43], p < 0.001), more likely to have undergone in vitro fertilization (IVF) for conception (10.9 vs. 3.8%, p = 0.001) and were of a more advanced gestational age at delivery (39.0 [25, 41] vs. 38.0 [20, 42], p = 0.006). In the subsequent pregnancy, the rate of PAS was significantly higher among the BPMF index cases (6.7 vs. 1.1%, p < 0.001). After adjusting for maternal age and IVF, a histopathological diagnosis of BPMF in an index pregnancy was shown to be a significant risk factor for PAS in the subsequent gestation (hazard ratio: 5.67 [95% confidence interval: 2.28, 14.06], p < 0.001).
Conclusion Our findings support that a histopathological diagnosis of BPMF is an independent risk factor for PAS in the subsequent pregnancy.
Key Points
Endoscopic submucosal dissection assisted by adaptive traction: results of the first 54 procedures
Authors: Masgnaux Louis-Jean , Grimaldi Jean , Rivory Jérôme , Ponchon Thierry , Yzet Clara , Wallenhorst Timothée , Lupu Alexandru , Lafeuille Pierre , Legros Romain , Rostain Florian , Jacques Jérémie , Pioche Mathieu 
Published: June 2023

Background Good submucosal exposure is key to successful endoscopic submucosal dissection (ESD) and can be achieved with various traction devices. Nevertheless, these devices have a fixed traction force that tends to decrease as the dissection progresses. In contrast, the ATRACT adaptive traction device increases traction during the procedure.
Methods In this retrospective analysis of prospectively collected data (from a French database), we analyzed ESD procedures performed with the ATRACT device between April 2022 and October 2022. The device was used consecutively whenever possible. We collected details of lesion characteristics, procedural data, histologic outcomes, and clinical consequences for the patient.
Results 54 resections performed in 52 patients by two experienced operators (46 procedures) and six novices (eight procedures) were analyzed. The ATRACT devices used were the ATRACT-2 (n = 21), the ATRACT 2 + 2 (n = 30), and the ATRACT-4 (n = 3). Four adverse events were observed: one perforation (1.9 %), which was closed endoscopically, and three delayed bleeding events (5.5 %). The R0 rate was 93 %, resulting in curative resection in 91 % of cases.
Conclusion ESD using the ATRACT device is safe and effective in the colon and rectum, but can also be used to assist with procedures in the upper gastrointestinal tract. It may be particularly useful in difficult locations.
BDNF and Krox20 as Indicators of Platelet-rich Plasma-Induced Nerve Regeneration in a Neuropathic Orofacial Pain Model
Authors: Winias Saka , Sarasati Andari , Wicaksono Satutya , Ayuningtyas Nurina Febriyanti , Ernawati Diah Savitri , Radithia Desiana 
Published: June 2023

Abstract
Objective Various growth factors contained in PRP can increase angiogenesis and cell proliferation, which plays an essential role in the process of neuroregeneration and peripheral nerve injury recovery. This study analyzed PRP effects in the neuro-regeneration of axonotmesis through brain-derived neurotrophic factor (BDNF) and Krox20 expressions.
Materials and Methods Freeze-dried allogeneic platelet-rich plasma (PRP) were prepared from allogeneic sources. Forty-two Rattus norvegicus were divided into three groups: negative control group, positive control group (crushing infraorbital nerve) and treatment group (crushing infraorbital nerve without PRP injection). Each group was observed for fourteen and twenty-one days after injury. Infraorbital nerve tissue is isolated for indirect immunohistochemistry examination with BDNF and Krox20 antibodies. Data analysis was performed using One-Way ANOVA and Mann-Whitney tests with significant value as p < 0.05.
Results The PRP group showed BDNF expression significantly higher than control positive groups, both observation days (p = 0.00). A higher Korx20 expression showed by the PRP group after 21 days than in the control positive groups (p = 0.002).
Conclusion PRP can potentially improve neuroregeneration of axonotmesis through increased BDNF and Krox20 expression on the twenty-one days after injury.
A Cross-sectional Study on the Effectiveness of Two Different Tooth-brushing Exercise Methods in Blind Childrendren
Authors: Pamewa Kurniaty , Musnamirwan Iwan Ahmad , Setiawan Arlette Suzy 
Published: June 2023

Abstract
Objective Blind children tend to have poor oral health. Oral health education is needed to reduce the prevalence of dental caries and periodontal diseases among blind children. The aim of this study was to evaluate the effectiveness of two tooth brushing exercise methods toward blind children’s knowledge, attitude, behavior, and oral hygiene.
Materials and Methods The purposive sampling technique was used in this study on 80 blind children aged between 7 and 16. Children were divided into two groups of 40 children each. In group I, children received the tooth-brushing exercise through the Braille–verbal method, and group II received the tactile–verbal method. Their knowledge, behavior, and attitude were recorded by a questionnaire, and their oral hygiene was assessed during a personal oral examination. Data were analyzed using Wilcoxon–Mann–Whitney non-parametric test.
Results Differences in effectiveness toward knowledge, attitude, and oral hygiene were found between both methods with the following values: p-value = 0.04 (<0.05), 0.04 (<0.05), and 0.0002 (<0.05). No difference in effectiveness toward behavior was found: p-value 0.30 (>0.05).
Conclusion The two tooth-brushing methods could change knowledge, attitude, and oral hygiene in blind children. The tactile–verbal method was more effective than the Braille–verbal method in changing blind children's oral hygiene.
Development and Evaluation of a New Orthodontic Ligature: Frictional Force Analysis
Authors: Cenci Jaisson , Busato Mauro Carlos Agner , Camilotti Veridiana , Mendonça Márcio José 
Published: June 2023

Abstract
Objective To evaluate and compare the friction of different ligature modes used in orthodontics, and to propose a new ligature model for conventional brackets (“H low-friction orthodontic ligature).
Materials and Methods Samples were randomly divided into seven experimental groups: (1) resin H ligature (H3D), designed by the authors of this study and produced in a 3D printer, with conventional bracket; (2) metal H ligature (HFM), with conventional bracket; (3) passive self-ligating bracket (SLP); (4) “8” low-friction unconventional elastic (LT8), with conventional bracket; (5) loose conventional metal ligature (MLS), with conventional bracket; (6) conventional metal ligature fully tightened (MLT), with conventional bracket; (7) conventional elastic ligature (CEL), with conventional bracket—control. All samples were subjected to mechanical static friction testing using the EMIC DL 2000 universal testing machine.
Statistical Analysis To assess the normality requirement, the Shapiro–Wilk test was used, which showed a non-normal distribution for the means of the groups (p < 0.05). Therefore, statistical tests were performed to assess the existence of statistically significant differences between the groups through the Kruskal–Wallis, followed by Dunn's test, pairwise comparison, p < 0.05.
Results The results obtained showed lower friction values for HFM (0.002 kgf), SLP (0.003 kgf), and LT8 (0.004 kgf)—these did not differ statistically from each other. These were followed by H3D (0.020 kgf), MLS (0.049 kgf), CEL (0.12 kgf), and, finally, MLT (0.21 kgf).
Conclusion The lowest friction value was found for the metal H ligature, similar to the self-ligating bracket and the “8” low-friction unconventional elastic. The resin H ligature presented intermediate friction values and the highest friction force was found for the MLT group.
A Simple, Rapid, and Cost-Effective PCR Procedure for Detection of NUDT15 Gene Variants in Vietnamese Patients with Acute Lymphoblastic Leukemia
Authors: Tram Duong Bich , Chuong Ho Quoc , Phuong Huynh Anh , Phung Nguyen The Nguyen , Nguyen Mai-Lan , Vu Hoang Anh 
Published: June 2023

Abstract
Objective The NUDT15 variants impact thiopurine dose selection in acute lymphoblastic leukemia patients. The ability to rapidly detect variants is important in clinical practice. This study aims to develop a simple polymerase chain reaction (PCR) procedure for detecting NUDT15 variants in Vietnamese patients.
Materials and Methods Sanger sequencing was used to determine NUDT15 variants from 200 patients. We designed primers and optimized the PCR procedure for detection of wild-type and variant alleles and compared with Sanger sequencing results.
Results The inserted variant c.55_56insGAGTCG was detected by differences in size through conventional PCR. The tetra-primer amplification refractory mutation system PCR was successful in detecting two variations, c.52G > A and c.415C > T. The sensitivity and specificity of PCR procedure achieved 100% when compared to 200 Sanger sequencing results.
Conclusion Our PCR procedure is suitable for replacing Sanger sequencing to detect the NUDT15 variants in clinical setting.
The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review
Authors: Wahyuningtyas Erdiarti Dyah , Triwardhani Ari , Ardani I Gusti Aju Wahju , Surboyo Meircurius Dwi Condro 
Published: June 2023

AbstractHerbal medicine has an important part in promoting and maintaining human health. One of them was grape seed extract (GSE). Various potentials of GSE in human health have been explored, and its potential for maintaining bone health is promising. Some initial research has provided evidence that the GSE was able to affect bone remodeling (bone resorption and bone formation). This scoping review analyzed and discussed all the reports on the effect of GSE on bone healing and bone remodeling in animals in the alveolar bone, jaw bone, and skeletal bone. The further purpose is to give an opportunity to research and development of supplementation of GSE for humans.The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines were used to compose this scoping review through database on Scopus, PubMed, Science Direct, Web of Science, Embase, and manual search until December 2022. The inclusion criteria were a study that analyzed the effect of supplementation GSE on all bones.All included study was in vivo study with supplementation of GSE. The supplementation of GSE affects the alveolar bone, jaw bones, and skeletal bone by promoting bone formation and inhibiting bone resorption by suppressing inflammation, apoptosis pathways, and osteoclastogenesis. It not only supports bone remodeling in bone inflammation, osteonecrosis, osteoporosis, and arthritis but also the GSE increases bone health by increasing the density and mineral deposition in trabecula and cortical bone.The supplementation of GSE supports bone remodeling by interfering with the inflammation process and bone formation not only by preventing bone resorption but also by maintaining bone density.
The Relationship between Emotional Intelligence, Self-Esteem, and Empathy among Nursing Students—A Pilot Study (Part 1)
Authors: Castelino Patsey Sera , Mendonca Theresa Leonilda 
Published: June 2023

Abstract
Objectives The aim of this study was to determine the relationship between emotional intelligence, self-esteem, and empathy of nursing students undergoing clinical experience in pediatric units.
Materials and Methods A cross-sectional survey was conducted and data were gathered from 60 BSc nursing students undergoing clinical experience in pediatric units. Self-report questionnaires assessing emotional intelligence, self-esteem, and empathy were used and information about demographic details was collected.
Statistical Analysis Pearson's correlation was used to find relationship between the constructs.
Results Nursing students had moderately high level of emotional intelligence. Nursing students had below average level of empathy. There was no significant relationship between emotional intelligence and empathy of nursing students. There was a significant positive relationship between emotional intelligence and self-esteem of nursing students. There was no significant relationship between empathy and self-esteem of nursing students.
Conclusion More research needs to be conducted to find the relationship between emotional intelligence, self-esteem, and empathy of nursing students so that proper training measures can be adopted to enhance these qualities which are crucial in providing quality care to the patients.
Should Sickle Cell Trait Be a Contraindication to Breast Reconstruction?—A Case Series Analysis
Authors: Webster Theresa K. , Araya Sthefano , Bartolacci Joseph , Amadio Grace M. , Panichella Juliet C. , Costa Joseph , Patel Sameer A. 
Published: June 2023

Abstract
Background While sickle cell disease has long been considered a contraindication to breast free flap reconstruction, there have been less definitive decisions about the impact of sickle cell trait on these procedures. We sought to analyze the patients with sickle cell trait who underwent free deep inferior epigastric perforator (DIEP) flap and pedicled latissimus dorsi (LD) flap at a single institution to determine the reconstructive outcomes.
Methods Patients with sickle cell trait who underwent breast free DIEP and pedicled LD reconstruction from 2007 to 2021 at a single institution by the lead surgeon were analyzed for demographics and surgical outcomes.
Results Four patients were identified as having sickle cell trait and having undergone a breast flap reconstruction. The average age of the patients was 54 years, median body mass index was 25, and past medical history was notable for one patient being a current smoker, and one patient having hypertension. Two patients received a unilateral free DIEP flap, one received a bilateral free DIEP flap, and one received a unilateral pedicled LD flap for a total of five flaps in four patients. Three of the patients received prior hormone therapy, one received prior radiation therapy, and one received prior chemotherapy. There were no instances of flap failure, vessel thrombosis, pulmonary embolism, or deep venous thrombosis. One patient experienced wound dehiscence.
Conclusion In this case series we present four patients with sickle cell trait who successfully underwent breast flap reconstruction without any instances of flap or systemic thrombosis. More work is needed to determine how to pre- and postoperatively optimize patients with sickle cell trait for favorable breast flap reconstruction outcomes.
Time-stretched multi-hit 3D velocity map imaging of photoelectrons
Authors: Goudreau E. Scott , Boguslavskiy Andrey E. , Moffatt Douglas J. , Makhija Varun , Hemsworth Michael , Lausten Rune , Marceau Claude , Wilkinson Iain , Stolow Albert 
Published: June 2023

The 2D photoelectron velocity map imaging (VMI) technique is commonly employed in gas-phase molecular spectroscopy and dynamics investigations due to its ability to efficiently extract photoelectron spectra and angular distributions in a single experiment. However, the standard technique is limited to specific light-source polarization geometries. This has led to significant interest in the development of 3D VMI techniques, which are capable of measuring individual electron positions and arrival times, obtaining the full 3D distribution without the need for inversion, forward-convolution, or tomographic reconstruction approaches. Here, we present and demonstrate a novel time-stretched, 13-lens 3D VMI photoelectron spectrometer, which has sub-camera-pixel spatial resolution and 210 ps (σ) time-of-flight (TOF) resolution (currently limited by trigger jitter). We employ a kHz CMOS camera to image a standard 40 mm diameter microchannel plate (MCP)/phosphor anode detector (providing x and y positions), combined with a digitizer pick-off from the MCP anode to obtain the electron TOF. We present a detailed analysis of time-space correlation under data acquisition conditions which generate multiple electrons per laser shot, and demonstrate a major advantage of this time-stretched 3D VMI approach: that the greater spread in electron TOFs permits for an accurate time- and position-stamping of up to six electrons per laser shot at a 1 kHz repetition rate.