bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advance drug delivery and combinational drug approaches for hepatoprotective action of berberine: A progressive overview with underlying mechanism
Authors: Sardana Satish , Gupta Rupa , Madan Kumud , Bisht Dheeraj , Rana Vijay Singh , Bhargava Samir , Sethiya Neeraj Kumar 
Published: January 2023

Abstract

Objectives
Berberine has attracted prominent interest recently due to its wide pharmacological actions in management and treatments of several disease including liver. However, restricted bioavailability and permeability makes this drug as better choice to develop several value added products for improvement of both safety and efficacy. Many of research already conducted in this direction using several approaches to fix this issue. Therefore, current article was designed to summarize all approaches taking together to enhance hepatoprotection by berberine including molecular mechanism.

Methods
Online scientific databases from PubMed was assessed for collecting information on berberine. All the collected informations were classified and incorporated into different sections such as recent progress of research on advance drug delivery systems and combinational approaches addressing above issue for improvement of hepatoprotective action of berberine.

Key finding
The electronically PubMed database search yielded 7454 articles from different countries in several languages. Out of them two seventy articles published between 1932 and 2022 were included, corresponding to all detailed overview on berberine including research pertaining on toxicity and safety, biodistribution, pharmacokinetics, biopharmaceutics classification system (BCS), hepatoprotection against various hepatotoxicant agent, advance drug delivery system, combinational drug approaches, clinical Trial for hepatoprotection and patents. The review of the literature reveals that berberine exhibits a potent hepatoprotective action with several molecular action mechanisms. Additionally, current trends of formulation technology for enhancement of hepatoprotective action of berberine in terms of safety and efficacy are well co-related with present work.

Conclusion
It was well established and concluded from present work that both advance drug delivery system and combinational drug approaches may serve for enhancement of restricted hepatoprotective action of berberine due to poor bioavailability, solubility and permeability. Additionally, berberine based advance delivery system including in combination with bioavailability and permeability enhancer may provide an added advantage in near future to meet the objectives.
Postoperative Complications of Appendectomy in Gynecologic Laparoscopic Surgery for Benign Indications
Authors: O'Brien M. Shea , Gupta Ankita , Quevedo Amira , Lenger Stacy M. , Shah Vishwa , Warehime Jenna , Gaskins Jeremy , Biscette Shan 
Published: January 2023

OBJECTIVE:
To assess whether concomitant appendectomy in patients who undergo laparoscopic surgery for benign gynecologic indications is associated with increased rates of complications in the 30-day postoperative period.

METHODS:
The American College of Surgeons National Surgical Quality Improvement Program database was used to identify patients who underwent laparoscopic surgery by a gynecologist. Patients were excluded if they underwent open abdominal surgeries, bowel resections, urogynecologic surgeries, or if diagnoses of cancer or appendicitis were present. There were 246,987 patients included in the population cohort from 2010 to 2020. Demographic information and postoperative outcomes of patients who underwent concomitant appendectomy were compared with patients who did not undergo appendectomy. A matched cohort was created by computing propensity scores, and outcomes were again compared between groups. All patients undergoing appendectomy were 1:1 matched to a unique patient who did not undergo appendectomy using a greedy matching based on the propensity score calculated from demographic and surgical characteristics.

RESULTS:
A total of 1,760 patients (0.7%) underwent concomitant appendectomy. There was an 8.0% complication rate in the appendectomy group, compared with 5.5% in the group of those without appendectomy (P<.001), and this was similar to the results in the propensity-matched sample. Patients who underwent appendectomy had significantly higher rates of readmission (4.3% vs 2.3%), which remained significant in the propensity-matched sample. There were no differences in the rates of postoperative thromboembolic events, blood transfusion, or reoperation.

CONCLUSION:
Patients who are undergoing concomitant appendectomy have an increased risk of any complication and hospital readmission. Additional studies may be conducted to identify patients with optimal risk benefit profiles when considering performing concomitant appendectomy at time of gynecologic surgery.
Disparities in Fertility-Sparing Treatment and Use of Assisted Reproductive Technology After a Diagnosis of Cervical, Ovarian, or Endometrial Cancer
Authors: Jorgensen Kirsten , Meernik Clare , Wu Chi-Fang , Murphy Caitlin C. , Baker Valerie L. , Jarmon Peiton , Brady Paula C. , Nitecki Roni , Nichols Hazel B. , Rauh-Hain Jose Alejandro 
Published: January 2023

OBJECTIVE:
To assess the presence of sociodemographic and clinical disparities in fertility-sparing treatment and assisted reproductive technology (ART) use among patients with a history of cervical, endometrial, or ovarian cancer.

METHODS:
We conducted a population-based cohort study of patients aged 18–45 years who were diagnosed with cervical cancer (stage IA, IB), endometrial cancer (grade 1, stage IA, IB), or ovarian cancer (stage IA, IC) between January 1, 2000, and December 31, 2015, using linked data from the CCR (California Cancer Registry), the California Office of Statewide Health Planning and Development, and the Society for Assisted Reproductive Technology. The primary outcome was receipt of fertility-sparing treatment, defined as surgical or medical treatment to preserve the uterus and at least one ovary. The secondary outcome was fertility preservation, defined as ART use after cancer diagnosis. Multivariable logistic regression analysis was used to estimate odds ratios and 95% CIs for the association between fertility-sparing treatment and exposures of interest: age at diagnosis, race and ethnicity, health insurance, socioeconomic status, rurality, and parity.

RESULTS:
We identified 7,736 patients who were diagnosed with cervical, endometrial, or ovarian cancer with eligible histology. There were 850 (18.8%) fertility-sparing procedures among 4,521 cases of cervical cancer, 108 (7.2%) among 1,504 cases of endometrial cancer, and 741 (43.3%) among 1,711 cases of ovarian cancer. Analyses demonstrated nonuniform patterns of sociodemographic disparities by cancer type for fertility-sparing treatment, and ART. Fertility-sparing treatment was more likely among young patients, overall, and of those in racial and ethnic minority groups among survivors of cervical and ovarian cancer. Use of ART was low (n=52) and was associated with a non-Hispanic White race and ethnicity designation, being of younger age (18–35 years), and having private insurance.

CONCLUSION:
This study demonstrates that clinical and sociodemographic disparities exist in the receipt of fertility-sparing treatment and ART use among patients with a history of cervical, endometrial, or ovarian cancer.
Changes to Prenatal Care Visit Frequency and Telehealth
Authors: Konnyu Kristin J. , Danilack Valery A. , Adam Gaelen P. , Friedman Peahl Alex , Cao Wangnan , Balk Ethan M. 
Published: January 2023

OBJECTIVE:
To systematically review patient, partner or family, and clinician perspectives, preferences, and experiences related to prenatal care visit schedules and televisits for routine prenatal care.

DATA SOURCES:
PubMed, the Cochrane databases, EMBASE, CINAHL, ClinicalTrials.gov, PsycINFO, and SocINDEX from inception through February 12, 2022.

METHODS OF STUDY SELECTION:
This review of qualitative research is a subset of a larger review on both the qualitative experiences and quantitative benefits and harms of reduced prenatal care visit schedules and televisits for routine prenatal care that was produced by the Brown Evidence-based Practice Center for the Agency for Healthcare Research and Quality. For the qualitative review, we included qualitative research studies that examined perspectives, preferences, and experiences about the number of scheduled visits and about televisits for routine prenatal care.

TABULATION, INTEGRATION, AND RESULTS:
We synthesized barriers and facilitators to the implementation of reduced care visits or of televisits into 1 of 14 domains defined by the Theoretical Domains Framework (TDF) and a Best Fit Framework approach. We summarized themes within TDF domains. We assessed our confidence in the summary statements using the GRADE-CERQual (Grading of Recommendations Assessment, Development and Evaluation—Confidence in Evidence from Reviews of Qualitative research) tool. Four studies addressed the number of scheduled routine prenatal visits, and five studies addressed televisits. Across studies, health care professionals believed fewer routine visits may be more convenient for patients and may increase clinic capacity to provide additional care for patients with high-risk pregnancies. However, both patients and clinicians had concerns about potential lesser care with fewer visits, including concerns about quality of care and challenges with implementing new delivery-of-care models.

CONCLUSION:
Although health care professionals and patients had some concerns about reduced visit schedules and use of televisits, several potential benefits were also noted. Our synthesis of qualitative evidence provides helpful insights into the perspectives, preferences, and experiences of important stakeholders with respect to implementing changes to prenatal care delivery that may complement findings of traditional quantitative evidence syntheses.

SYSTEMATIC REVIEW REGISTRATION:
PROSPERO, CRD42021272287.
State Perinatal Quality Collaborative for Reducing Severe Maternal Morbidity From Hemorrhage
Authors: Wiesehan Erik C. , Keesara Sirina R. , Krissberg Jill R. , Main Elliott K. , Goldhaber-Fiebert Jeremy D. 
Published: January 2023

OBJECTIVE:
To evaluate the cost effectiveness of California's statewide perinatal quality collaborative for reducing severe maternal morbidity (SMM) from hemorrhage.

METHODS:
A decision-analytic model using open source software (Amua 0.30) compared outcomes and costs within a simulated cohort of 480,000 births to assess the annual effect in the state of California. Our model captures both the short-term costs and outcomes that surround labor and delivery and long-term effects over a person's remaining lifetime. Previous studies that evaluated the effectiveness of the CMQCC’s (California Maternal Quality Care Collaborative) statewide perinatal quality collaborative initiative—reduction of hemorrhage-related SMM by increasing recognition, measurement, and timely response to postpartum hemorrhage—provided estimates of intervention effectiveness. Primary cost data received from select hospitals within the study allowed for the estimation of collaborative costs, with all other model inputs derived from literature. Costs were inflated to 2021 dollars with a cost-effectiveness threshold of $100,000 per quality-adjusted life-year (QALY) gained. Various sensitivity analyses were performed including one-way, scenario-based, and probabilistic sensitivity (Monte Carlo) analysis.

RESULTS:
The collaborative was cost effective, exhibiting strong dominance when compared with the baseline or standard of care. In a theoretical cohort of 480,000 births, collaborative implementation added 182 QALYs (0.000379/birth) by averting 913 cases of SMM, 28 emergency hysterectomies, and one maternal mortality. Additionally, it saved $9 million ($17.78/birth) due to averted SMM costs. Although sensitivity analyses across parameter uncertainty ranges provided cases where the intervention was not cost saving, it remained cost effective throughout all analyses. Additionally, scenario-based sensitivity analysis found the intervention cost effective regardless of birth volume and implementation costs.

CONCLUSION:
California's statewide perinatal quality collaborative initiative to reduce SMM from hemorrhage was cost effective—representing an inexpensive quality-improvement initiative that reduces the incidence of maternal morbidity and mortality, and potentially provides cost savings to the majority of birthing hospitals.
Redo Ileocolic Resection is Not an Independent Risk Factor for Anastomotic Leak in Recurrent Crohn’s Disease
Authors: Yang Songsoo , Prien Christopher , Jia Xue , Hull Tracy , Liska David , Steele Scott R. , Lightner Amy L. , Valente Michael , Holubar Stefan D. 
Published: January 2023

BACKGROUND:
Redo ileocolic resection for recurrent Crohn’s disease is associated with increased technical complexity and higher complication rates compared to primary resection. Literature concerning redo surgery for recurrent Crohn’s disease is scarce and no studies have identified risk factors for postoperative anastomotic leak.

OBJECTIVE:
We hypothesized redo ileocolic resection for Crohn’s disease is an independent risk factor for anastomotic leak.

DESIGN:
Retrospective, case-control study from 1994 – 2019 with multivariate analysis and propensity-score weighting.

SETTING:
Quaternary, inflammatory bowel disease-referral center.

PATIENTS:
Adult patients >18 years old.

INTERVENTIONS:
Primary or redo ileocolic resection with an anastomosis, with or without diverting ileostomy.

MAIN OUTCOME MEASURES:
30-day anastomotic leak rate.

RESULTS:
A total of 991 patients (56% primary and 44% redo ileocolic resections) were included. Redo patients were significantly older with more comorbidities, fewer medications, and less fistulizing disease compared to the primary group. On univariate analysis, redo patients had more overall complications (50.5% vs. 36.2%, p < 0.001) and the cumulative number of prior ileocolic resections was significantly associated with increased risk for overall morbidity (p < 0.001). There were 31 (3%) anastomotic leaks; leak rates did not differ between groups (p = 0.60). Multivariable analysis indicated extensive adhesiolysis (p < 0.001), ileostomy omission (p = 0.009), and intraoperative abscess/fistula (p = 0.02) were independently associated with leaks, but not redo resection (p = 0.27). Patients with 0, 1, 2, or 3 of these risk factors had observed leak rates of 1.1%, 1.3%, 6.0%, and 11.6.% (p = 0.03), respectively.

LIMITATIONS:
Selection bias, Referral bias, Single quaternary center

CONCLUSION:
Compared to primary procedures, redo ileocolic resection for recurrent Crohn’s disease is associated with increased overall morbidity, but not anastomotic leak. See Video Abstract at http://links.lww.com/DCR/C132.
Absorbable Barbed Continuous versus Nonabsorbable Nonbarbed Interrupted Suturing Methods for Donor-site Closure of the Rectus Abdominis Myocutaneous Flap
Authors: Kitano Daiki , Nomura Tadashi , Sakakibara Shunsuke , Terashi Hiroto 
Published: January 2023

Background:
Abdominal incisional hernia is a complication of the rectus abdominis myocutaneous (RAMC) flap harvest. This study aimed to compare the incidence of abdominal incisional hernia and donor-site closure time between absorbable barbed continuous (ABC) and non-absorbable non-barbed interrupted (nAnBI) methods.

Methods:
This study included 145 patients who underwent free RAMC flap reconstruction after head and neck cancer surgery at Kobe University Hospital between January 2012 and March 2020. The nAnBI method was selected between January 2012 and August 2016, and the ABC method was selected between September 2016 and March 2020. The incidence of abdominal incisional hernia and the average time required for donor-site closure were compared between the two groups.

Results:
Of the 145 patients surveyed, 116 (57 and 59 in the nAnBI and ABC groups, respectively) were followed-up for at least 90 days after the surgery. The incidence rates of abdominal incisional hernia were 0% and 5.1% (n = 3) in the nAnBI and ABC groups, respectively, with no significant differences (p = 0.244). The average donor-site closure times were 127.6 and 111.3 minutes in the nAnBI and ABC groups, respectively, with no significant differences (p = 0.122).

Conclusions:
No significant differences in the incidence of abdominal incisional hernia and donor-site closure time were observed between the nAnBI and ABC groups. However, there was a tendency for increased hernia occurrence and shorter wound closure time in the ABC group. A randomized prospective multicenter study is warranted to validate our findings of the ABC method.
Health Promotion Model-Based Skin Health Program to Improve Skin Health Behaviors, Quality of Life, and Self-Efficacy and Reduce Eczema Symptoms in Hairdresser Apprentices
Authors: Aktas Emine , Esin M. Nihal 
Published: January 2023

Purpose
The aim of this study was to evaluate the effectiveness of the skin health promotion program based on the health promotion model (HPM) to reduce hand eczema (HE) symptom severity and improve skin health behavior in young hairdressers and barber apprentices.

Design and Methods
The study was designed as pretest–posttest quasi-experimental control group research with repetitive measurements in the first-, third-, and sixth-month follow-up, which included 96 young workers (intervention = 48, control = 48). The program, as secondary prevention, consists of training with evidence-based recommendations, cognitive determinants, and practices to improve skin health behaviors.

Findings
The mean age of the young workers was 20.77 ± 4.85 years. After the sixth month of intervention, total severity scores of HE symptoms in the intervention group were significantly decreased from 5.92 to 2.91. In addition, the frequency of skin health behaviors and cognitive factors showed statistically positive changes (p < .05).

Conclusions
The skin health promotion program based on HPM is effective in reducing HE symptoms and improving the skin health behaviors of young workers. Healthcare professionals, especially nurses, can use the HPM-based skin health program to improve skin health and psychological health resulting from skin disease symptoms in other specific skin diseases for their patients.
5-Year Observation Period of Quality of Life After Cochlear Implantation
Authors: Weichbold Viktor , Zelger Philipp , Galvan Oliver , Muigg Franz 
Published: January 2023

Background
Only few studies assessed health-related quality of life (HRQoL) in cochlear implant (CI) patients for a period of more than 2 years. Some of these studies indicated that HRQoL might decrease after that period. The goal of our study was to see whether HRQoL indeed decreases or remains stable beyond 2 years after implant activation.

Methods
Twenty-five adults (11 women, 14 men; mean age at implantation: 60 ± 19 yr) with a unilateral CI for profound hearing loss were administered two questionnaires: the Nimjegen Cochlear Implant Questionnaire and the Health Utility Index 3 (HUI 3). The Nimjegen Cochlear Implant Questionnaire total score and the HUI single-attribute utility score of Hearing are measures of hearing-specific HRQoL, whereas the HUI multiattribute utility score is a measure of generic HRQoL. The questionnaires were administered before cochlear implantation and 1, 2, and 5 years after implant activation.

Results
Hearing-specific HRQoL was significantly improved at 1 year after implant activation and did not significantly change thereafter. Generic HRQoL also showed significant improvement at 1 year after implant activation, but deteriorated to a clinically relevant degree thereafter.

Conclusions
The significant improvement of hearing-specific HRQoL obtained from cochlear implantation was fully maintained for up to 5 years after implantation. Generic HRQoL of our CI patients, however, fluctuated over time. The decrease of generic HRQoL is supposed to reflect general age-associated health declines.
Migratory birds are able to choose the appropriate migratory direction under dim yellow monochromatic light
Authors: Romanova Nadezhda , Utvenko Gleb , Prokshina Anisia , Cellarius Fyodor , Fedorischeva Aleksandra , Pakhomov Alexander 
Published: January 2023

AbstractPreviously it has been shown that migratory birds were oriented in the appropriate migratory direction under UV, blue and green monochromatic lights (short-wavelength) and were unable to use their magnetic compass in total darkness and under yellow and red light (long-wavelength). Currently, it is generally assumed that the magnetic compass of birds works correctly only under short-wavelength light. However, it also been suggested that the magnetic compass has two sensitivity peaks: in the short and long wavelengths, but with different intensities. In this project, we aimed to study the orientation of long-distance migrants, pied flycatchers (Ficedula hypoleuca), in different monochromatic lights during autumn migration. The birds were tested in the natural magnetic field (NMF) and 120° CCW shifted magnetic field (CMF) under green and yellow light (intensity 1 mW m−2). All tests were performed in a specially constructed wooden laboratory equipped with magnetic coils to manipulate the magnetic field. We showed that (1) pied flycatchers were completely disoriented under green light both in the NMF and CMF but (2) showed the migratory direction in NMF and the appropriate response to CMF under yellow light. Our data contradict results of previous experiments under monochromatic yellow light and might indicate the previously proposed hypothesis of two different mechanisms in avian magnetoreception (a high-sensitive short-wavelength mechanism and a low-sensitive mechanism in the long-wavelength spectrum) has a right to exist.
Primed to resolve: A single cell atlas of the shoulder capsule reveals a cellular basis for resolving inflammatory fibrosis
Authors: Ng Michael TH , Borst Rowie , Gacaferi Hamez , Davidson Sarah , Machado Caio C , Reekie Ian , Attar Moustafa , Windell Dylan , Kurowska-Stolarska Mariola , MacDonald Lucy , Alivernini Stefano , Garvilles Micon , Jansen Kathrin , Bhalla Ananya , Lee Angela , Charlesworth James , Chowdhury Rajat , Klenerman Paul , Powell Kate , Hackstein Carl-Philip ,   ICECAP study group, Furniss Dominic , Rees Jonathan , Gilroy Derek , Coles Mark , Carr Andrew J , Sansom Stephen N , Buckley Christopher D , Dakin Stephanie G 
Published: January 2023

ABSTRACTFibrotic conditions are a significant global disease burden. While some therapies delay disease progression, none reverse fibrosis. To gain insights into how fibrosis might resolve, we developed a comparative single cell atlas of frozen shoulder capsule tissue; a chronic inflammatory fibrotic human disease that resolves spontaneously. We identified both a population of pro-inflammatory MERTKlowCD48+ macrophages (Mφ) and a population of MERTK+LYVE1+MRC1+Mφ enriched for negative regulators of inflammation. Micro-cultures of patient-derived cells identified cell-matrix interactions between MERTK+Mφ and DKK3+ and POSTN+ fibroblasts, suggesting that matrix remodelling plays a role in the resolution of frozen shoulder. Cross-tissue analysis revealed a shared gene expression cassette between MERTK+Mφ in the shoulder capsule and a similar cell population enriched in synovial tissues from rheumatoid arthritis patients in disease remi ssion, supporting the concept that MERTK+Mφ provide a cellular basis for the resolution of inflammation and fibrosis. Single-cell transcriptomic profiling and spatial analysis of human foetal shoulder tissues identified MERTK+LYVE1+MRC1+Mφ and DKK3+ and POSTN+ fibroblast populations analogous to those identified in adult shoulder capsule, suggesting that the template to resolve fibrosis is established during development. Therapeutic enhancement of crosstalk between MerTK+Mφ and pro-resolving DKK3+ and POSTN+ fibroblasts could accelerate resolution of frozen shoulder and resolve persistent inflammatory fibrotic disease in other tissues.