bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced models for respiratory disease and drug studies
Authors: Shrestha Jesus , Paudel Keshav Raj , Nazari Hojjatollah , Dharwal Vivek , Bazaz Sajad Razavi , Johansen Matt D. , Dua Kamal , Hansbro Philip M. , Warkiani Majid Ebrahimi 
Published: April 2023

AbstractThe global burden of respiratory diseases is enormous, with many millions of people suffering and dying prematurely every year. The global COVID‐19 pandemic witnessed recently, along with increased air pollution and wildfire events, increases the urgency of identifying the most effective therapeutic measures to combat these diseases even further. Despite increasing expenditure and extensive collaborative efforts to identify and develop the most effective and safe treatments, the failure rates of drugs evaluated in human clinical trials are high. To reverse these trends and minimize the cost of drug development, ineffective drug candidates must be eliminated as early as possible by employing new, efficient, and accurate preclinical screening approaches. Animal models have been the mainstay of pulmonary research as they recapitulate the complex physiological processes, Multiorgan interplay, disease phenotypes of disease, and the pharmacokinetic behavior of drugs. Recently, the use of advanced culture technologies such as organoids and lung‐on‐a‐chip models has gained increasing attention because of their potential to reproduce human diseased states and physiology, with clinically relevant responses to drugs and toxins. This review provides an overview of different animal models for studying respiratory diseases and evaluating drugs. We also highlight recent progress in cell culture technologies to advance integrated models and discuss current challenges and present future perspectives.
Targeting epigenetic modifications in Parkinson's disease therapy
Authors: Zhang Dan , Zhang Jifa , Wang Yuxi , Wang Guan , Tang Pan , Liu Yun , Zhang Yiwen , Ouyang Liang 
Published: April 2023

AbstractParkinson's disease (PD) is a multifactorial disease due to a complex interplay between genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms involved in regulating pathways related to the development of PD, including DNA methylation, posttranslational modifications of histones, and the presence of microRNA (miRNA or miR). Epigenetic regulators are potential therapeutic targets for neurodegenerative disorders. In the review, we aim to summarize mechanisms of epigenetic regulation in PD, and describe how the DNA methyltransferases, histone deacetylases, and histone acetyltransferases that mediate the key processes of PD are attractive therapeutic targets. We discuss the use of inhibitors and/or activators of these regulators in PD models or patients, and how these small molecule epigenetic modulators elicit neuroprotective effects. Further more, given the importance of miRNAs in PD, their contributions to the underlying mechanisms of PD will be discussed as well, together with miRNA‐based therapies.
Profiling of small‐molecule necroptosis inhibitors based on the subpockets of kinase–ligand interactions
Authors: Xu Lijuan , Zhuang Chunlin 
Published: April 2023

AbstractNecroptosis is a highly regulated cell death (RCD) form in various inflammatory diseases. Receptor‐interacting protein kinase 1 (RIPK1) and RIPK3 are involved in the pathway. Targeting the kinase domains of RIPK1 and/or 3 is a drug design strategy for related diseases. It is generally accepted that essential reoccurring features are observed across the human kinase domains, including RIPK1 and RIPK3. They present common N‐ and C‐terminal domains that are built up mostly by α‐helices and β‐sheets, respectively. The current RIPK1/3 kinase inhibitors mainly interact with the kinase catalytic cleft. This article aims to present an in‐depth profiling for ligand–kinase interactions in the crucial cleft areas by carefully aligning the kinase‐ligand cocrystal complexes or molecular docking models. The similarity and differential structural segments of ligands are systematically evaluated. New insights on the adaption of the conserved and selective kinase domains to the diversity of chemical scaffolds are also provided. In a word, our analysis can provide a better structural requirement for RIPK1 and RIPK3 inhibition and a guide for inhibitor discovery and optimization of their potency and selectivity.
Propagation dynamics of a discrete diffusive equation with non‐local delay
Authors: Tian Ge , Zhang Guo‐Bao 
Published: April 2023

This paper is concerned with the propagation dynamics of a discrete diffusive equation with non‐local delay. First of all, by exploring the asymptotic behavior of the solution of the upper system corresponding to the perturbation equation, we obtain the global stability of semi‐wavefronts. It is noteworthy that the kernel function
can be asymmetric (i.e.,
). Secondly, we estimate the level set of the equation on the basis of the above stability. In particular, the results show that the solution of the compact supported initial value problem is not persistent in special case.
MicroRNA‐29a Compromises Hepatic Adiposis and Gut Dysbiosis in High Fat Diet‐Fed Mice via Downregulating Inflammation
Authors: Yang Ya‐Ling , Huang Ying‐Hsien , Wang Feng‐Sheng , Tsai Ming‐Chao , Chen Chien‐Hung , Lian Wei‐Shiung 
Published: April 2023

ScopemiR‐29a expression patterns influence numerous physiological phenomena. Of note, upregulation of miR‐29a ameliorates high‐fat diet (HFD)‐induced liver dysfunctions in mice. However, the miR‐29a effect on gut microbiome composition and HFD‐induced gut microbiota changes during metabolic disturbances remains unclear. The study provides compelling evidence for the protective role of miR‐29a in gut barrier dysfunction and steatohepatitis.Methods and resultsmiR‐29a overexpressed mice (miR‐29aTg) are bred to characterize intestinal, serum biochemical, and fecal microbiota profiling features compared to wild‐type mice (WT). Mice are fed an HFD for 8 months to induce steatohepatitis, and intestinal dysfunction is determined via histopathological analysis. miR‐29aTg has better lipid metabolism capability that decreases total cholesterol and triglyceride levels in serum than WT of the same age. The study further demonstrates that miR‐29aTg contributes to intestinal integrity by maintaining periodic acid Schiff positive cell numbers and diversity of fecal microorganisms. HFD‐induced bacterial community disturbance and steatohepatitis result in more severe WT than miR‐29aTg. Gut microorganism profiling reveals Lactobacillus, Ruminiclostridium_9, and Lachnoclostridium enrichment in miR‐29aTg and significantly decreases interleukin‐6 expression in the liver and intestinal tract.ConclusionThis study provides new evidence that sheds light on the host genetic background of miR‐29a, which protects against steatohepatitis and other intestinal disorders.
Triple‐band metasurface absorber for RF energy harvesting applications
Authors: Agrahari Rajan , Singh Satyesh , Samantaray Diptiranjan , Kumar Bambam , Bhattacharyya Somak , Mahto Manpuran , Jain Pradip K. 
Published: April 2023

AbstractEnergy harvesting is expected to be ubiquitous and essential to modern‐day life in the future. The limitations of ambient sources, such as thermal, mechanical, and solar, for energy harvesting can be overcome by RF energy harvesting for low‐power devices. With the help of perfect metasurface absorbers, an electromagnetic wave can be used as an ambient source for energy harvesting. In this paper, a simple polarization‐insensitive triple‐band perfect metasurface absorber is proposed for RF energy harvesting applications. The three‐layer (metal–dielectric–metal) meta‐atom of the designed metasurface consists of a cross‐shaped metal patch surrounded by slotted square‐shaped metallic patches and of meta‐atoms. The absorber is typically developed in S‐ and C‐bands with resonant frequencies of 3.06, 3.9, and 5.97 GHz. The absorption is near unity which persists over a wide angle of incidence. The experimental results are in close agreement, within 2%, with the simulation results. The reliability of the proposed absorber has been determined for the RF energy harvesting applications, and a high harvesting efficiency of 94.4% and 84% has been observed at 3.07 and 5.97 GHz, respectively.
Correlation of muscle ultrasound with clinical and pathological findings in idiopathic inflammatory myopathies
Authors: Yoshida Takeshi , Yamazaki Hiroki , Nishimori Yukako , Takamatsu Naoko , Fukushima Koji , Osaki Yusuke , Taniguchi Yoshinori , Nozaki Taiki , Kumon Yoshitaka , Albayda Jemima , Nishino Ichizo , Izumi Yuishin 
Published: April 2023

AbstractIntroduction/AimsIn idiopathic inflammatory myopathies (IIMs), the change in muscle echogenicity and its histopathological basis are not well understood. We quantitatively measured muscle echogenicity in patients with IIMs and evaluated its correlation with disease activity and histopathological findings.MethodsThis study involved patients with IIMs who underwent both ultrasonography (US) and muscle biopsy, as well as age‐ and sex‐matched rheumatoid arthritis patients as inflammatory disease controls. On US, axial images of the right biceps brachii and vastus medialis were obtained. Standardized histopathological scoring was used to quantitatively measure each pathological domain.ResultsForty‐two patients (17 with inclusion body myositis [IBM] and 25 with IIMs other than IBM) and 25 controls were included. The muscle echo intensity (EI) of patients with IIMs was significantly higher than that of controls. Muscle EI showed significant correlations with creatine kinase (r = 0.66, p < .001) and muscle strength (r = −0.73, p < .0001) in patients with non‐IBM IIMs. In patients with IBM, moderate correlation was found between muscle EI and quadriceps muscle strength (r = −0.53, p = .028). Histopathologically, the number of infiltrating CD3+ inflammatory cells correlated with muscle EI in the non‐IBM group (r = 0.56, p = .017), but not in the IBM group.DiscussionMuscle EI may be useful as a surrogate marker of muscle inflammation in non‐IBM IIM. Increased muscle EI may be difficult to interpret in patients with long‐standing IBM, which has advanced and complex histopathology.
P1$$ {P}_1 $$–Nonconforming quadrilateral finite element space with periodic boundary conditions: Part I. Fundamental results on dimensions, bases, solvers, and error analysis
Authors: Yim Jaeryun , Sheen Dongwoo 
Published: April 2023

AbstractThe –nonconforming quadrilateral finite element space with periodic boundary conditions is investigated. The dimension and basis for the space are characterized by using the concept of minimally essential discrete boundary conditions. We show that the situation is different based on the parity of the number of discretizations on coordinates. Based on the analysis on the space, we propose several numerical schemes for elliptic problems with periodic boundary conditions. Some of these numerical schemes are related to solving linear equations consisting of non‐invertible matrices. By courtesy of the Drazin inverse, the existence of corresponding numerical solutions is guaranteed. The theoretical relation between the numerical solutions is derived, and it is confirmed by numerical results. Finally, the extension to the three dimensions is provided.
Strength prediction and experimental damage investigations of plain woven CFRPs with interacting holes using multi‐instrument measurements
Authors: Khan Raja Muhammad Awais , Shafighfard Torkan , Ali Hafiz Qasim , Mieloszyk Magdalena , Yildiz Mehmet 
Published: April 2023

AbstractComposite structures with holes have been utilized in different applications, for example, swash plates, adaptor plates, and repair patches. These notches reduce the structural performance of the composite plates. In a woven composite plate with two interacting holes, the orientation of the holes affects the stress concentration factor (SCF) and strength of the laminate. The SCF determined by finite‐element method (FEM) shows that the structural performance of the sample with a single hole is improved through drilling one more hole along the loading direction. The main purpose of this article is to investigate, numerically and experimentally, the interaction between two holes, oriented at different angles, when the plate is subjected to tension. The location of the critical region depends on the configuration of the holes. The critical region and characteristic distances are established for each sample combining the FEM and digital image correlation (DIC) techniques. Point stress criterion (PSC) and extended‐PSC (EPSC) methods are utilized to predict the final failure strength of specimens. The failure progression under the influence of interaction between the two holes is investigated by infrared thermography (IRT). Moreover, to complement the IRT and mechanical results, fractographic analysis is conducted and it is concluded that a delamination dominated fracture along loading direction takes place in samples with two holes while a transversal matrix dominated failure is observed for the single notch specimen.
Adoption of inpatient family‐based treatment for anorexia nervosa: A case report
Authors: Nishiura Sayaka , Miyawaki Dai , Goto Ayako , Kaoru Hirai , Sakamoto Shoko , Hama Hiroki , Kadono Shin , Inoue Koki 
Published: April 2023

AbstractBackgroundFamily‐based treatment (FBT) is effective for the treatment of anorexia nervosa (AN) in children and adolescents. However, its availability in Japan is limited because it requires adherence to specific guidelines, commitment of sufficient time for frequent outpatient treatment, as well as the entire family's participation. We present a case of a patient with AN who was treated with modified FBT during hospitalization.Case PresentationOur patient was a 14‐year‐old girl with AN. She was hospitalized for malnutrition and dehydration, and was introduced to FBT during this period. After discharge, she continued FBT on an outpatient basis and was in remission 1 year later.ConclusionThis case shows that initiation of FBT during hospitalization may be useful in patients with physically severe AN. Flexible adaptation to each of the diverse healthcare systems and cultural differences may be necessary for the widespread use of FBT.
Bring the outcome expectations back in: Chinese adolescent perceived value of effort and academic achievement
Authors: Xie Yongxiang , He Jun 
Published: April 2023

AbstractThe existing literature mainly examines the impact of academic self‐efficacy on academic achievement in educational psychology. Much less is known about the relationship between outcome expectations and adolescent academic achievement. This article applies the random intercept model to investigate the association between Chinese adolescent perceived value of effort as outcome expectations and academic achievement and employs the Karlson, Holm, and Breen (KHB) method to examine the underlying mechanisms. Additionally, this paper uses the random coefficient model to explore the heterogeneous association between the perceived value of effort and adolescent academic achievement across families and schools. Based on the Programme for International Students Assessment 2018 (N = 11751; 48.07% females), we found that the adolescent perceived value of effort was significantly and positively correlated with academic achievement. Adolescent educational expectations and academic engagement partially mediated the relationship between the perceived value of effort and academic achievement. Adolescents from disadvantaged families and schools benefited more from the perceived value of effort. These findings enhance existing literature by revealing how the adolescent outcome expectations contribute to academic achievement and provide a scientific basis for bridging the gap in academic achievement between families and schools to promote equity in education.
Applying distributed practice in the schools to enhance retention of spelling words
Authors: Petersen‐Brown Shawna , Riese Abbey M. , Schneider Melissa M. , Ray Jannine E. , Clonkey Hannah R. 
Published: April 2023

AbstractDistributed practice is often cited as a best practice for instruction, although research on the application of spaced practice to schools is limited. The impact of practice distributed across days and the impact of practice distributed within sessions were examined. Second and third grade participants (n = 88) were randomly assigned to practice eight spelling words in a massed or distributed fashion, both within sessions and across sessions. Retention was measured immediately and 28 days after the final practice sessions. No differences in immediate retention were observed. Retention after 28 days was greater when across‐session distributed practice was provided. These results suggested that practice distributed across weekly sessions was most beneficial.
Registration of oat cultivar ‘Rushmore’
Authors: Caffe Melanie , Hall Lon , Hall Nicholas , Bauer Rachel , Kleinjan Jonathan , Graham Christopher , Ingemansen Jack A. , Turnipseed Brent , Krishnan Padmanaban 
Published: April 2023

AbstractMore awareness from consumers on the health benefits of oat (Avena sativa L.) in the last few decades has increased the demand for oat. However, in the United States, oat production has continued to decline. Most of the oats used in U.S. food products are imported from Canada. Although oats are known to fit well in corn (Zea mays L.)–soybean [Glycine max (L.) Merr] rotations, difficulties in marketing the grain and relatively low prices in comparison to corn and soybeans have limited the number of acres planted to oats. High‐yielding oat cultivars adapted to the Northern Great Plains with high test weight and good milling characteristics are needed. ‘Rushmore’ (Reg. no. CV‐388, PI 698122) is a spring oat cultivar released by the South Dakota Agricultural Experiment Station in 2019. Rushmore was derived from the three‐way cross SD080015//SD070110/SD060130 and developed using a modified bulk and single‐seed descent method. Prior to release, Rushmore was tested in the uniform early oat performance nursery in 2016 and 2017 and in the South Dakota Crop Performance Testing oat variety trial since 2017. Rushmore was evaluated as experimental line SD140515 and evaluated for grain yield, test weight, disease resistance, lodging resistance, grain shape, milling characteristics, and grain composition. Rushmore was released to oat producers due to its combination of high grain yield, excellent test weight, lodging and disease resistance, and good milling characteristics. The excellent test weight potential of Rushmore is expected to help producers in marketing their grain to the feed and food industries.
Registration of ‘ND Frohberg’ hard red spring wheat
Authors: Green Andrew J. , Mergoum Mohamed , Frohberg Richard , Underdahl Jesse , Walz Adam , Selland Thor , Miranda Andre , Simsek Senay , Otteson Brian , Heilman‐Morales Ana Maria , Murillo Didier , Friskop Andrew , Rickertsen John , Ostlie Mike , Schatz Blaine , Hanson Bryan , Mehlhoff Randy , Eriksmoen Eric , Martin Glenn , Fiedler Jason , Rasmussen Jack , Zhong Shaobin , Liu Zhaohui , Friesen Tim , Rouse Matthew , Jin Yue , Dill‐Macky Ruth , Curland Rebecca D. , Gill Upinder 
Published: April 2023

Abstract‘ND Frohberg’ (Reg. no. CV‐1200, PI 698310) is a hard‐red spring wheat (HRSW; Triticum aestivum L.) developed at North Dakota State University (NDSU) and released by the North Dakota Agricultural Experiment Station (NDAES) in 2020. ND Frohberg was selected from the cross ND709‐9/ND2902. ND709‐9 was an experimental line with the pedigree (ND 2709/3/’Grandin’*3//’Ramsey’/ND 622). ND2902 was an experimental line with the pedigree (ND674//ND2710/ND688). It was tested as experimental line NDHRS16‐13‐97 and released because of improved straw strength, yield potential, strong disease resistance and end‐use quality. ND Frohberg is highly resistant to stem rust (caused by Puccinia graminis f.sp. tritici), and moderately resistant to leaf rust (caused by Puccinia triticina), bacterial leaf streak (caused by Xanthomonas translucens pv. undulosa), and Fusarium head blight (caused by Fusarium graminearum). The name ND Frohberg was chosen to honor Dr. Richard Frohberg, hard red spring wheat breeder at NDSU for 37 years. During his tenure at NDSU, Dr. Frohberg's varieties were widely cultivated, reaching as much as 65% of the acreage in North Dakota in 2003. He was responsible for the cross that resulted in this variety.
An unexpected change in reaction mechanism in the homo‐Diels‐Alder cycloadditions of N‐methyl‐1,2,4‐triazoline‐3,5‐dione with a series of bicycloalkadienes
Authors: Breton Gary W. 
Published: April 2023

AbstractBicycloalkadienes are known to engage in homo‐Diels‐Alder reactions with potent dienophiles such as N‐substituted 1,2,4‐triazoline‐3,5‐diones (TAD). We investigated the reaction of N‐methyl TAD (MeTAD) with the three dienes bicyclo[2.2.1]hepta‐2,5‐diene (norbornadiene), bicyclo[2.2.2]octa‐2,5‐diene, and bicyclo[3.2.2]nona‐6,8‐diene experimentally and computationally. Experimentally, the C7 and C8 dienes resulted in the formation of the expected homo‐Diels‐Alder product. However, the C9 diene formed a rearranged adduct that could be explained by the intermediacy of an aziridinium imide intermediate. These findings were supported by computational studies (ωB97X‐D/def2‐SVP{CH2Cl2}) in which not only were the observed products predicted but transition states leading to the products were successfully located. Ultimately, it was determined that subtle differences in transition state structures and energies determine the course of the reaction.
Doped Graphene Quantum Dots Modified Zn0.9Cd0.1Se for Improved Photoelectric Properties
Authors: Lei Yun , Chen Jiong , Wu Yuncui , Bao Shenxu , Du Peng , Wang Yongqin , Li Can , Du Beibei , Luo Linhui 
Published: April 2023

AbstractS‐graphene quantum dots (GQDs), N‐GQDs, P‐GQDs, and Cl‐GQDs are prepared by a solution chemistry method and further incorporated with ZnxCd1−xSe by one‐step hydrothermal method. In the previous study, ZnxCd1−xSe reached the optimal photoelectric performances at the Zn/Cd ratio of 0.9:0.1, so the Zn0.9Cd0.1Se were combined with doped GQDs (D‐GQDs) to form Zn0.9Cd0.1Se/doped‐GQDs. The influence of GQDs doped with different elements on the photoelectric properties of Zn0.9Cd0.1Se composites is discussed. Compared with pristine Zn0.9Cd0.1Se, Zn0.9Cd0.1Se/Cl‐GQDs, and Zn0.9Cd0.1Se/P‐GQDs can improve the photocurrent response and current intensity, therein, Zn0.9Cd0.1Se/Cl‐GQDs reaches the lowest interfacial charge transfer resistance and the highest photocurrent response of 5.48 × 10−6 A cm−2. Mott–Schottky analysis shows that the fitting slope of Zn0.9Cd0.1Se/Cl‐GQDs composites is significantly lower than that of Zn0.9Cd0.1Se/GQDs with other doped elements. The results indicate that Zn0.9Cd0.1Se/Cl‐GQDs composites has the largest carrier density, which is beneficial to charge conduction.