bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate reputation and culture: the link between knowledge management and sustainability
Authors: Arduini Simona , Manzo Martina , Beck Tommaso 
Published: September 2023

Purpose
This study aims to analyze how sustainability, through an efficient knowledge management (KM) system, can serve as a driving force with respect to corporate culture and reputation. The research questions that guided this study are mainly the following: Are KM and sustainability related? Can culture strengthen the link between KM and sustainability? Can the link between KM and sustainability be affected by reputation?

Design/methodology/approach
The methodological approach adopted corresponds to qualitative research of analysis on the reference literature in the international field, also supported by empirical analysis.

Findings
In this study, the authors show that there is no explicit correlation between sustainability and KM. This relationship, in fact, is not underlined in nonfinancial reporting because it is absent or because it is not considered relevant. Too often sustainability is reduced to a mere relational and reputational tool, ignoring the fact it must be considered a consequence and not the main goal to improve companies’ culture.

Research limitations/implications
The sample studied by the authors refers to the top 40 companies listed on the Italian market, not allowing to generalize the findings across the international context.

Practical implications
The practical implications that could result from making explicit the relationship between sustainability and KM are multiple: the substantial benefits of the reputational aspect, an increase in the economic value related to sustainability; to ensure the going concern of the company and implement its ability to produce and share value in the long term.

Social implications
The social benefits of a stronger relationship between sustainability and KM are related to the possibility to improve the wealth of all the stakeholders.

Originality/value
This paper analyzes the links between sustainability and KM to understand the influence of these factors on corporate culture and reputation.
Dreaming beyond education policy: a BlackCrit analysis of ESEA and ESSA
Authors: Robinson Robert P. , Bell Jordan 
Published: September 2023

Purpose
The purpose of this study is to analyze the first major federal education policy, the Elementary and Secondary Education Act of 1965, and the most recent federal policy, the Every Student Succeeds Act of 2015, through a Black critical theory (BlackCrit) lens to understand better how these educational policies have served as antiblack projects. Furthermore, this study locates examples of educational Freedom Dreams in the past and present to imagine new possibilities in Black education.

Design/methodology/approach
By analyzing education policy documents and history through BlackCrit methods, the authors expose how education policy is inherently an antiblack project. Freedom Dreams catalyze possibilities for future education.

Findings
The data confirms that while these policies purport equity and accountability in education, they, in practice, exacerbate antiblackness through inequitably mandated standardized testing, distributed funding and policed schooling.

Originality/value
This paper applies BlackCrit analysis of education policy to reimagine Black educational possibilities.
Global trends in disruptive technological change: social and policy implications for education
Authors: Moravec John W. , Martínez-Bravo María Cristina 
Published: September 2023

Purpose
The purpose of this study is to identify global trends in disruptive technological change and map the social and policy implications, particularly as they relate to the educational ecosystem and main stakeholders across all levels of education.

Design/methodology/approach
The authors conducted a two-stage meta-analysis of 1,155 scholarly, peer-reviewed articles. The investigation involves a systematized literature review for data identification and collation adhering to defined selection criteria, and a network analysis to scrutinize data, consolidate information and unveil correlations and patterns from the literature review to produce a set of recommendations.

Findings
The study unveiled educational trends related to disruptive technologies and delineated four principal clusters representing how these technologies are transforming the education ecosystem. Additionally, a series of transversal aspects that reveal a societal vulnerability toward future prospects in the realms of ethics, sustainability, resilience, security, and policy were identified.

Practical implications
The findings spotlight an enlarging chasm between industry (and society at large) and conventional education, where many transformations triggered by disruptive technologies remain absent from teaching and learning systems. The study further offers recommendations and envisions potential scenarios, urging stakeholders to respond based on their positions concerning disruptive technologies.

Originality/value
Expanding from the meta-analysis of pertinent literature, this paper offers four collections of curated resources, four mini case studies and four scenarios for policymakers and local communities to consider, enabling them to plot courses for their optimal futures.
Thematic group activities: accommodating the individual needs of clients undergoing therapeutic community approach in Indonesia
Authors: Sarasvita Riza , Haryanto Haryanto , Isfandari Siti , Raharni Raharni , Jody Yoseph , Hernawati Debby , Baringbing Anzany Tania Dwi Putri , Isnaini Fitri , Octarina Linda 
Published: September 2023

Purpose
Therapeutic community (TC) is a primary approach that has been used in all Indonesian National Narcotics Board residential treatment centers since 2012. In TC, all daily activities are strengthened into habits and routines without strong therapeutic or educational reasons. But recently, the TC members become more critical and have growing individual needs. Thus, the Indonesian National Narcotics Board (INNB) tried to combine the TC approach with thematic group activities (TGA) intervention using an integrated individual approach to improve the outcomes. This study aims to evaluate the client’s behavioral changes after undergoing a TC approach added with TGA intervention for two months.

Design/methodology/approach
A mixed-methods study with the pre-post design was applied to 122 participants from six INNB rehabilitation centers. Pre-post behavioral changes were measured by using Client Evaluation of Self Treatment, University Rhode Island Change Assessment Scale, modified-Addiction Severity Index 3.0 and World Health Organization-Quality of Life instruments. Analysis was done by using univariate and bivariate on quantitative data, focus group discussion, and medical record review.

Findings
The participants’ mean age was 30.57 years, majority male, 50% graduated from senior high schools and were employed. Bivariate analysis resulted statistically significant (p-value < 0.05) in tendencies to seek treatment, participate more actively, maintain a good relationship with counselors during the program, and decrease the psychological problems of participants. The client’s social state, as well as adaptation to the program, were also amended.

Originality/value
TGA-added TC approach was proven to improve clients’ behavioral changes, particularly in social functioning, program involvement and psychological conditions, in people with substance use disorders.
Integrons, transposons and IS elements promote diversification of multidrug resistance plasmids and adaptation of their hosts to antibiotic pollutants from pharmaceutical companies
Authors: Shintani Masaki , Vestergaard Gisle , Milaković Milena , Kublik Susanne , Smalla Kornelia , Schloter Michael , Udiković‐Kolić Nikolina 
Published: September 2023

AbstractPlasmids are important vehicles for the dissemination of antibiotic resistance genes (ARGs) among bacteria by conjugation. Here, we determined the complete nucleotide sequences of nine different plasmids previously obtained by exogenous plasmid isolation from river and creek sediments and wastewater from a pharmaceutical company. We identified six IncP/P‐1ε plasmids and single members of IncL, IncN and IncFII‐like plasmids. Genetic structures of the accessory regions of the IncP/P‐1ε plasmids obtained implied that multiple insertions and deletions had occurred, mediated by different transposons and Class 1 integrons with various ARGs. Our study provides compelling evidence that Class 1 integrons, Tn402‐like transposons, Tn3‐like transposons and/or IS26 played important roles in the acquisition of ARGs across all investigated plasmids. Our plasmid sequencing data provide new insights into how these mobile genetic elements could mediate the acquisition and spread of ARGs in environmental bacteria.
Antibacterial properties of peptides from chia (Salvia hispanica L.) applied to pork meat preservation
Authors: León Madrazo Anaí , Segura Campos Maira Rubi 
Published: September 2023

AbstractChia‐derived peptides might represent a novel alternative to conventional preservatives in food. Despite the antibacterial potential of these molecules, their food application is still limited. This study aimed to evaluate chia‐derived peptides' antibacterial and antibiofilm potential in food preservation. The peptides YACLKVK, KLKKNL, KLLKKYL, and KKLLKI were synthesized, and their antibacterial activity against Listeria monocytogenes, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Salmonella Enteritidis was evaluated through microdilution tests. A bacterial killing kinetic assay determined bacterial growth over time. The ability to prevent and eradicate S. aureus biofilm was assessed by crystal violet staining. The hemolytic and cytotoxic activities were determined in human red blood cells and fibroblasts using free hemoglobin detection and (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) assays, respectively. Finally, a microbial challenge was performed on meat samples inoculated with L. monocytogenes and S. Enteritidis to determine their inhibitory effects on pork meat. Results showed the potential antibacterial activity of these peptides, with minimum inhibitory concentrations ranging from 0.23 to 5.58 mg/mL. Biofilm inhibition percentages were above 40%, and eradication percentages were lower than 20%. In vitro assays in human red blood cells and fibroblasts demonstrated that peptides are not hemolytic or cytotoxic agents. In microbiological challenge testing, KKLLKI showed the most promising antibacterial effects against S. Enteritidis on refrigerated pork meat samples. These findings suggest that chia‐derived peptides have the potential as natural food preservatives due to their antibacterial and antibiofilm properties. Notably, KKLLKI demonstrated promising antibacterial effects against Salmonella spp. on a complex food matrix, such as pork meat.Practical ApplicationChia‐derived peptides can be a safer alternative to synthetic preservatives in the food industry because the latter may be detrimental to human health. Salmonella spp. growth on chilled pork meat was shown to be inhibited by the peptide KKLLKI, indicating that the use of these peptides may offer a more secure and natural alternative to synthetic preservatives.
Increased occurrence of liver and gastrointestinal diseases and anaemia in women with Turner syndrome – a nationwide cohort study
Authors: Viuff Mette Hansen , Stochholm Kirstine , Grønbæk Henning , Berglund Agnethe , Juul Svend , Gravholt Claus Højbjerg 
Published: September 2023

SummaryBackgroundLiver and gastrointestinal diseases are frequent in women with Turner syndrome. However, their association with bleeding disorders, anaemia and the impact of hormone replacement therapy is unknown.AimsTo investigate the risk of liver and gastrointestinal diseases, haemorrhage and anaemia in women with Turner syndrome compared with the female background population, and the long‐term impact of hormone replacement therapy on these conditions.MethodsOne thousand one hundred and fifty‐six women with Turner syndrome diagnosed during 1960‐2014 were identified using the Danish Cytogenetic Central Registry and linked with personal‐level data from the National Patient Registry and the Medication Statistics Registry. Statistics Denmark randomly identified 115 577 age‐matched female controls. Negative binomial regression was used to analyse hospital discharge diagnoses. Medical prescriptions, mortality and the effect of hormone replacement therapy were estimated using stratified Cox regression.ResultsLiver disease increased 13‐fold (IRR 12.9 (95% CI 5.8‐28.8)), due to toxic liver disease (IRR 8.0 (95% CI 1.8‐35.4)), liver insufficiency (IRR 6.7 (95% CI 1.7‐26.9)), fibrosis/cirrhosis (IRR 16.5 (95% CI 2.2‐122.1)) and unspecified liver disease (IRR 10.6 (95% CI 4.4‐25.3)). Furthermore, presence of abnormal liver enzymes increased 12‐fold (IRR 12.4 (95% CI 4.2‐36.6)). The risk of gastrointestinal haemorrhage (IRR 3.4 (95% CI 1.8‐6.2)), anaemia (IRR 3.2 (95% CI 2.0‐5.0)) and coagulation disorders (IRR 2.9 (95% CI 1.1‐7.1)) was increased. However these diagnoses were not associated with inflammatory bowel disease. Gastrointestinal mortality was increased three‐fold (HR 3.1 (95% CI 1.5‐6.2)), partly due to death by liver disease (HR 3.0 (95% CI 1.1‐8.2)), gastrointestinal haemorrhage (HR 29.6 (95% CI 3.1‐285.1)) and capillary malformations (HR 18.6 (95% CI 4.1‐85.0)). There was no effect of hormone replacement therapy on gastrointestinal risk but a trend towards a beneficial impact on liver diseases.ConclusionsThe risk of being diagnosed with liver disease was higher than previously reported. The occurrence of gastrointestinal haemorrhage and anaemia was increased in Turner syndrome. There was no effect of hormone replacement therapy on gastrointestinal risk but a trend towards a beneficial impact on liver diseases was detected.
Letter: ustekinumab for the treatment of post‐surgical and refractory Crohn's disease
Authors: Tursi Antonio , Mocci Giammarco , Picchio Marcello , Elisei Walter , Maconi Giovanni 
Published: September 2023

LINKED CONTENTThis article is linked to Biemans et al paper. To view this article, visit https://doi.org/10.1111/apt.15745
Standardisation of intestinal ultrasound scoring in clinical trials for luminal Crohn’s disease
Authors: Goodsall Thomas M. , Jairath Vipul , Feagan Brian G. , Parker Claire E. , Nguyen Tran M. , Guizzetti Leonardo , Asthana Anil K. , Begun Jakob , Christensen Britt , Friedman Antony B. , Kucharzik Torsten , Lee Andrew , Lewindon Peter J. , Maaser Christian , Novak Kerri L. , Rimola Jordi , Taylor Kirstin M. , Taylor Stuart A. , White Lauren S. , Wilkens Rune , Wilson Stephanie R. , Wright Emily K. , Bryant Robert V. , Ma Christopher 
Published: September 2023

SummaryBackgroundIntestinal ultrasound (IUS) is a valuable tool for assessment of Crohn’s disease (CD). However, there is no widely accepted luminal disease activity index.AimsTo identify appropriate IUS protocols, indices, items, and scoring methods for measurement of luminal CD activity and integration of IUS in CD clinical trials.MethodsAn expert international panel of adult and paediatric gastroenterologists (n = 15) and radiologists (n = 3) rated the appropriateness of 120 statements derived from literature review and expert opinion (scale of 1‐9) using modified RAND/UCLA methodology. Median panel scores of 1 to ≤3.5, >3.5 to <6.5 and ≥6.5 to 9 were considered inappropriate, uncertain and appropriate ratings respectively. The statement list and survey results were discussed prior to voting.ResultsA total of 91 statements were rated appropriate with agreement after two rounds of voting. Items considered appropriate measures of disease activity were bowel wall thickness (BWT), vascularity, stratification and mesenteric inflammatory fat. There was uncertainty if any of the existing IUS disease activity indices were appropriate for use in CD clinical trials. Appropriate trial applications for IUS included patient recruitment qualification when diseased segments cannot be adequately assessed by ileocolonoscopy and screening for exclusionary complications. At outcome assessment, remission endpoints including BWT and vascularity, with or without mesenteric inflammatory fat, were considered appropriate. Components of an ideal IUS disease activity index were identified based upon panel discussions.ConclusionsThe panel identified appropriate component items and applications of IUS for CD clinical trials. Empiric evidence, and development and validation of an IUS disease activity index are needed.
Maternal thiopurine metabolism during pregnancy in inflammatory bowel disease and clearance of thiopurine metabolites and outcomes in exposed neonates
Authors: Flanagan Emma , Wright Emily K. , Hardikar Winita , Sparrow Miles P. , Connell William R. , Kamm Michael A. , De Cruz Peter , Brown Steven J. , Thompson Alexander , Greenway Anthea , Westley Ian , Barclay Murray , Ross Alyson L. , Kiburg Katerina V. , Bell Sally J. ,   PICCOLO Study Group
Published: September 2023

SummaryBackgroundAzathioprine and mercaptopurine are considered safe during pregnancy. However, the pharmacokinetic effects of pregnancy on thiopurine metabolism are undefined.AimsTo characterise thiopurine metabolism in pregnancy and measure infant metabolite levels and outcomes.MethodsWomen with IBD who were taking a thiopurine and pregnant or trying to conceive were recruited. Maternal thiopurine metabolites were measured pre‐conception, in each trimester, at delivery and post‐partum. Infant metabolite levels, full blood examination and liver function testing were performed at birth, and repeated until levels undetectable and haematological and biochemical abnormalities resolved.ResultsForty patients were included with measurements on at least two occasions, and two with only mother‐baby levels at delivery. The median maternal 6‐TGN level dropped in the second trimester compared with post‐partum (179.0 vs 323.5 pmol/8 × 108 RBCs, P < 0.001) and the median 6‐MMP level increased in the second trimester compared with post‐partum (1103.0 vs 329.5 pmol/8 × 108 RBCs, P < 0.01). At delivery, the median 6‐TGN level was lower in infants (n = 20) than mothers (78.5 vs 217 pmol/8 × 108 RBCs) (P < 0.001). Metabolites were not detected at 6 weeks in any infants. Anaemia was not seen, but thrombocytosis and abnormal liver biochemistry were detected in 80% of infants from 6 weeks, which gradually improved.Conclusions6‐TGN levels decrease and 6‐MMP levels increase in the second trimester of pregnancy. Infants are exposed to thiopurine metabolites at low levels with clearance by 6 weeks and no anaemia. The cause of infant thrombocytosis and abnormal liver biochemistry in the absence of metabolites is unclear.
Review article: potassium‐competitive acid blockers for the treatment of acid‐related disorders
Authors: Abdel‐Aziz Yousef , Metz David C. , Howden Colin W. 
Published: September 2023

SummaryBackgroundPotassium‐competitive acid blockers (P‐CABs) are a novel group of acid‐suppressing medicines for the management of acid‐related disorders.AimsTo review published clinical pharmacology studies and clinical trials of P‐CABs.MethodsWe conducted a comprehensive literature search including Medline (PubMed), EMBASE, Web of Science and the Cochrane Library from inception until November 2020, for studies of the clinical pharmacology of P‐CABs and relevant clinical trials of those that are currently licensed or in development.ResultsMost publications concerned vonoprazan, which forms the bulk of this review. It is currently licensed in some Asian and South American countries and is being developed for North America. In clinically relevant doses, P‐CABs have produced more rapid and profound suppression of intragastric acidity than proton pump inhibitors (PPIs). Vonoprazan was non‐inferior to lansoprazole in healing erosive oesophagitis (2 randomised controlled trials [RCTs] in 1137 subjects) and superior in maintaining remission (1 RCT; 607 subjects). In 2 RCTs (1120 total subjects), both vonoprazan and tegoprazan were non‐inferior to lansoprazole for healing peptic ulcers. Three RCTs and numerous non‐randomised studies have compared vonoprazan‐based and PPI‐based regimens forHelicobacter pyloriinfection; vonoprazan‐based triple or dual regimens have been highly effective.ConclusionsP‐CABs have some potential advantages over PPIs. To date, most research has been conducted in Asia; results of clinical trials that are underway in the United States and Europe are anticipated in 2021.
Outcomes after double switching from originator Infliximab to biosimilar CT‐P13 and biosimilar SB2 in patients with inflammatory bowel disease: a 12‐month prospective cohort study
Authors: Trystram Noémie , Abitbol Vered , Tannoury Jenny , Lecomte Mahaut , Assaraf Julie , Malamut Georgia , Gagnière Charlotte , Barré Amélie , Sobhani Iradj , Chaussade Stanislas , Amiot Aurélien 
Published: September 2023

SummaryBackgroundThere are few data regarding multiple switching from the originator Infliximab to its biosimilars.AimTo assess outcomes and patient perspectives in a prospective manner after double switching from Infliximab to the biosimilars CT‐P13 and SB2.MethodsA total of 158 consecutive patients with inflammatory bowel disease (IBD) receiving CT‐P13 maintenance therapy were switched to SB2 and followed for 54 weeks. Patients were stratified according to previous switch from the originator Infliximab to CT‐P13 (double switch group) or not (single switch group).ResultsThe drug persistence was high (94.9%) after 54 weeks. In total, 17 (10.8%) patients experienced loss of response to SB2, including 10 patients who were managed through dose optimisation and continued treatment. No changes were observed in clinical activity scores, fatigue, biological activity and pharmacokinetical parameters after the switch. The safety profile was in line with the current knowledge of Infliximab. According to the Beliefs about Medicines Questionnaire, the patients’ perspectives did not change after switching from CT‐P13 to SB2. The primary patient concerns remained after the switch, which were focused on effectiveness and safety rather than on the molecular differences between originator and biosimilars or socioeconomic benefits. There were also no differences in the concerns and beliefs between the double and single switch groups.ConclusionDouble switching from the originator Infliximab to CT‐P13 and then to SB2 was not associated with an impairment in patient beliefs, while the effectiveness, immunogeniity and safety of anti‐TNF therapy remained stable after 54 weeks of follow‐up.
Editorial: machine learning models for gastric cancer risk prediction—authors' reply
Authors: Leung Wai K. , Lui Thomas K. L. 
Published: September 2023

LINKED CONTENTThis article is linked to Leung et al and Spaander & Kuipers papers. To view these articles, visit https://doi.org/10.1111/apt.16272 and https://doi.org/10.1111/apt.16303
Letter: risk of severe COVID‐19 outcomes associated with inflammatory bowel disease medications—reassuring insights from the United Kingdom PREPARE‐IBD multicentre cohort study
Authors: Lamb Christopher A. , Sebastian Shaji , Kent Alexandra J. , Segal Jonathan P. , Gonzalez Haidee A. , Brookes Matthew J. , Mehta Shameer J. , Subramanian Sreedhar , Bhala Neeraj , Hicks Lucy C. , Conley Thomas E. , Patel Kamal V. , Walker Gareth J. , Kennedy Nicholas A. ,   the PREPARE‐IBD Study Group
Published: September 2023

LINKED CONTENTThis article is linked to Taxonera et al paper. To view this article, visit https://doi.org/10.1111/apt.15804
Letter: enhancing training opportunities for upper GI bleeding in Sheffield—a UK transferable model?
Authors: Adu‐Tei Sebastian , Raju Suneil A. , Marks Lauren J. S. , Daoub Mohamed , Kakkar Nishchay , Bevis Edwin D. A. , Shiha Mohamed G. , Ching Hey‐Long , Thoufeeq Mo , Sanders David S. 
Published: September 2023

LINKED CONTENTThis article is linked to Chaudhary et al and Chaudhary & Stanley papers. To view these articles, visit https://doi.org/10.1111/apt.16170 and https://doi.org/10.1111/apt.16368