bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic relevance of sarcopenia, geriatric, and nutritional assessments in older patients with diffuse large B-cell lymphoma: results of a multicentric prospective cohort study
Authors: Pénichoux Juliette , Lanic Hélène , Thill Caroline , Ménard Anne-Lise , Camus Vincent , Stamatoullas Aspasia , Lemasle Emilie , Leprêtre Stéphane , Lenain Pascal , Contentin Nathalie , Kraut-Tauzia Jerôme , Fruchart Christophe , Kammoun Leila , Damaj Gandhi , Farge Agathe , Delette Caroline , Modzelewski Romain , Vaudaux Sandrine , Pépin Louis-Ferdinand , Tilly Hervé , Jardin Fabrice 
Published: April 2023

AbstractThis prospective study aimed to investigate the prognostic effect of sarcopenia, geriatric, and nutritional status in older patients with diffuse large B-cell lymphoma (DLBCL). Ninety-five patients with DLBCL older than 70 years who were treated with immunochemotherapy were included. The lumbar L3 skeletal muscle index (L3-SMI) was measured by computed tomography at baseline, and sarcopenia was defined as low L3-SMI. Geriatric assessment included G8 score, CIRS-G scale, Timed Up and Go test, and instrumental activity of daily living. Nutritional status was assessed using the Mini Nutritional Assessment and the body mass index, and several scores used in the literature incorporating nutritional and inflammatory biomarkers, namely the Nutritional and inflammatory status (NIS), Geriatric Nutritional Risk Index, Prognostic Nutritional Index, and Glasgow Prognostic Score.Fifty-three patients were considered sarcopenic. Sarcopenic patients displayed higher levels of inflammation markers and lower levels of prealbumin than non-sarcopenic patients. Sarcopenia was associated with NIS, but was not associated with severe adverse events and treatment disruptions. They were, however, more frequent among patients with elevated NIS. Sarcopenia did not appear in this study as a prognostic factor for progression-free survival (PFS) or overall survival (OS). However, NIS emerged as predictive of the outcome with a 2-year PFS rate of 88% in the NIS ≤ 1 group and 49% in the NIS > 1 group and a significant effect in a multivariate analysis for both PFS (p = 0.049) and OS (HR = 9.61, CI 95% = [1.03–89.66], p = 0.04). Sarcopenia was not associated with adverse outcomes, but was related to NIS, which appeared to be an independent prognostic factor.
Downscaling long lead time daily rainfall ensemble forecasts through deep learning
Authors: Jin Huidong , Jiang Weifan , Chen Minzhe , Li Ming , Bakar K. Shuvo , Shao Quanxi 
Published: April 2023

AbstractSkilful and localised daily weather forecasts for upcoming seasons are desired by climate-sensitive sectors. Various General circulation models routinely provide such long lead time ensemble forecasts, also known as seasonal climate forecasts (SCF), but require downscaling techniques to enhance their skills from historical observations. Traditional downscaling techniques, like quantile mapping (QM), learn empirical relationships from pre-engineered predictors. Deep-learning-based downscaling techniques automatically generate and select predictors but almost all of them focus on simplified situations where low-resolution images match well with high-resolution ones, which is not the case in ensemble forecasts. To downscale ensemble rainfall forecasts, we take a two-step procedure. We first choose a suitable deep learning model, very deep super-resolution (VDSR), from several outstanding candidates, based on an ensemble forecast skill metric, continuous ranked probability score (CRPS). Secondly, via incorporating other climate variables as extra input, we develop and finalise a very deep statistical downscaling (VDSD) model based on CRPS. Both VDSR and VDSD are tested on downscaling 60 km rainfall forecasts from the Australian Community Climate and Earth-System Simulator Seasonal model version 1 (ACCESS-S1) to 12 km with lead times up to 217 days. Leave-one-year-out testing results illustrate that VDSD has normally higher forecast accuracy and skill, measured by mean absolute error and CRPS respectively, than VDSR and QM. VDSD substantially improves ACCESS-S1 raw forecasts but does not always outperform climatology, a benchmark for SCFs. Many more research efforts are required on downscaling and climate modelling for skilful SCFs.
Experiences of sexual well-being interventions in males affected by genitourinary cancers and their partners: an integrative systematic review
Authors: Schubach Kathryn , Niyonsenga Theo , Turner Murray , Paterson Catherine 
Published: April 2023

Abstract
Purpose
Sexual well-being has been identified as an unmet supportive care need among many individuals with genitourinary (GU) cancers. Little is known about the experiences of using sexual well-being interventions among men and their partners.

Methods
This review was reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and followed a systematic review protocol. Data extraction and methodological quality appraisal were performed, and a narrative synthesis was conducted.

Results
A total of 21 publications (reporting on 18 studies) were included: six randomised control trials, seven cross-sectional studies, three qualitative studies, and five mixed methods studies. Sexual well-being interventions comprised medical/pharmacological and psychological support, including counselling and group discussion facilitation. The interventions were delivered using various modes: face-to-face, web-based/online, or telephone. Several themes emerged and included broadly: (1) communication with patient/partner and healthcare professionals, (2) educational and informational needs, and (3) timing and/or delivery of the interventions.

Conclusion
Sexual well-being concerns for men and their partners were evident from diagnosis and into survivorship. Participants benefited from interventions but many articulated difficulties with initiating the topic due to embarrassment and limited access to interventions in cancer services. Noteworthy, all studies were only representative of men diagnosed with prostate cancer, underscoring a significant gap in other GU cancer patient groups where sexual dysfunction is a prominent consequence of treatment.

Implications for cancer survivors
This systematic review provides valuable new insights to inform future models of sexual well-being recovery interventions for patients and partners with prostate cancer, but further research is urgently needed in other GU cancer populations.
Efficacy and volume stability of a customized allogeneic bone block for the reconstruction of advanced alveolar ridge deficiencies at the anterior maxillary region: a retrospective radiographic evaluation
Authors: Blume Oliver , Back Michael , Dinya Elek , Palkovics Daniel , Windisch Peter 
Published: April 2023

Abstract
Objectives
The aim of this retrospective case series was to evaluate the efficacy and volume stability of a customized allogeneic bone block (CABB) for the hard tissue reconstruction of severely atrophied anterior maxillary ridges.

Materials and methods
Hard tissue alterations between baseline (T1), 2-month follow-up (T2), and 6-month follow-up (T3) cone-beam computed tomography scans were evaluated with semi-automatic segmentation. Following automatic spatial alignment of the datasets, 3D subtraction analysis was performed. The volume stability of the inserted allogeneic bone block was determined on the basis of the ratio of the T3 and T2 hard tissue volumes.

Results
The newly formed hard tissue volume at T2 averaged at of 0.75 cm3 ± 0.57 cm3, whereas at T3, an average of 0.52 cm3 ± 0.42 cm3 volumetric hard tissue gain could be detected. The T3/T2 ratio was found to be 67.83% ± 18.72% on average. The dice similarity coefficient between the T2 and T3 hard tissue models averaged at 0.73 ± 0.15.

Conclusions
Cancellous CABBs are a reliable option for the reconstruction of severely atrophied alveolar ridges. The resorption rates of these grafts are similar to those found in the literature; however, with precise manufacturing and proper intraoperative flap management, the resorption rates may be reduced.

Clinical relevance
With precise knowledge of the resorption patterns, the shape of blocks can be altered in the future to compensate for the volumetric loss.
Early morning physical activity is associated with healthier white matter microstructure and happier children: the ActiveBrains project
Authors: Esteban-Cornejo Irene , Lara-Jimenez Inmaculada , Rodriguez-Ayllon Maria , Verdejo-Roman Juan , Catena Andres , Erickson Kirk I. , Ortega Francisco B. 
Published: April 2023

AbstractThe background of this study is to examine the associations of individual and combined early morning patterns (i.e., active commuting to school, physical activity before school, having breakfast and good sleep) with white matter microstructure (WMM) and, whether the associated white mater microstructure outcomes were related to mental health outcomes in children with overweight or obesity. 103 children with overweight or obesity (10.0 ± 1.1 years old, 42 girls) from the ActiveBrains project participated in this cross-sectional study. Early morning patterns and mental health indicators (i.e., self-esteem, optimism, positive and negative affect, stress, depression and anxiety) were self-reported by the children using validated questionnaires. WMM was assessed by magnetic resonance imaging using diffusion tensor imaging. When examined independently, early morning patterns were not related with WMM (allP > 0.05). However, the combination of early morning patterns was related with WMM (P < 0.05). Specifically, physically active early morning patterns (i.e., active commuting to school and physical activity before school) were associated with global fractional anisotropy (FA) (β = 0.298,P = 0.013) and global radial diffusivity (RD) (β = − 0.272,P = 0.021), as well as with tract-specific FA (β = 0.314,P = 0.004) and RD (β = − 0.234,P = 0.032) in the superior longitudinal fasciculus (SLF). Furthermore, combined physically active early morning pattern-associated global (i.e., FA and RD) and tract-specific (i.e., FA and RD in the SLF) WMM indicators were positively associated with happiness (βabsolute value range from 0.252 to 0.298, allP < 0.05). A combination of physically active early morning patterns may positively relate to white matter microstructure in children with overweight or obesity, and, in turn, happiness.
SeQual: an unsupervised feature selection method for cloud workload traces
Authors: Ali Shallaw Mohammed , Kecskemeti Gabor 
Published: April 2023

AbstractOne challenge of studying cloud workload traces is the lack of available users’ identities. Therefore, clustering methods were used to address this challenge through extracting these identities from workload traces. For better extraction, it is beneficial to select attributes (columns in the traces) for clustering by using feature selection methods. However, the use of general selection methods requires details that are not available for workload traces (e.g. predefined number of clusters). Therefore, in this paper, we present an unsupervised feature selection method for cloud workload traces to identify good candidate attributes for clustering. This method uses Silhouette coefficients to rank attributes that are best for users’ extraction through clustering. The performance of our SeQual method is evaluated in comparison with commonly used (supervised and unsupervised) feature selection methods with the help of clustering quality metrics (i.e. adjusted rand index, entropy and precision). The results show that the SeQual method can compete with the supervised methods and perform better than unsupervised ones, with an average accuracy between 90% and 99%.
Environmental impact of potentially toxic elements on soils, sediments, waters, and air nearby an abandoned Hg-rich fahlore mine (Mt. Avanza, Carnic Alps, NE Italy)
Authors: Barago Nicolò , Mastroianni Cristiano , Pavoni Elena , Floreani Federico , Parisi Filippo , Lenaz Davide , Covelli Stefano 
Published: April 2023

AbstractThe decommissioned fahlore Cu-Sb(-Ag) mine at Mt. Avanza (Carnic Alps, Italy) is a rare example of exploited ore deposits, as the tetrahedrite (Cu6[Cu4(Fe,Zn)2]Sb4S13) is the main ore mineral found. This multi-compartmental geochemical characterisation approach provides one of the first case studies regarding the geochemical behaviour and fate of Hg, Sb, As, Cu, and other elements in solid and water matrices and of Hg in the atmosphere in an environment affected by the mining activity of a fahlore ore deposit. Elevated concentrations of the elements (Cu, Sb, As, Pb, Zn, Hg) associated with both (Zn-Hg)-tetrahedrite and to other minor ore minerals in mine wastes, soils, and stream sediments were observed. Concentrations in waters and stream sediments greatly decreased with increasing distance from the mining area and the Igeo index values testify the highest levels of sediment contamination inside the mine area. Thallium and Ge were associated with the “lithogenic component” and not to sulfosalt/sulphide minerals. Although mine drainage water often slightly exceeded the national regulatory limits for Sb and As, with Sb being more mobile than As, the relatively low dissolved concentrations indicate a moderate stability of the tetrahedrite. The fate of Hg at the investigated fahlore mining district appeared similar to cinnabar mining sites around the world. Weak solubility but the potential evasion of gaseous elemental mercury (GEM) into the atmosphere also appear to be characteristics of Hg in fahlore ores. Although GEM concentrations are such that they do not present a pressing concern, real-time field surveys allowed for the easy identification of Hg sources, proving to be an effective, suitable high-resolution indirect approach for optimising soil sampling surveys and detecting mine wastes and mine adits.
Protectin DX as a therapeutic strategy against frailty in mice
Authors: Perazza Laís R. , Gower Adam C. , Brown-Borg Holly M. , Pajevic Paola Divieti , Thompson LaDora V. 
Published: April 2023

AbstractFrailty in aging is driven by the dysregulation of multiple biological pathways. Protectin DX (PDX) is a docosahexaenoic acid (DHA)-derived molecule that alleviates many chronic inflammatory disorders, but its potential effects on frailty remain unknown. Our goal is to identify age-related impairments in metabolic systems and to evaluate the therapeutic potential of PDX on frailty, physical performance, and health parameters. A set of 22-month-old C57BL/6 male and female mice were assigned to vehicle (Old) or PDX daily gavage treatment for 9 weeks, whereas 6-month-old (Adult) mice received only vehicle. Forelimb and hindlimb strength, endurance, voluntary wheel activity and walking speed determined physical performance and were combined with a frailty index score and body weight loss to determine frailty status. Our data shows that old vehicle-treated mice from both sexes had body weight loss paralleling visceromegaly, and Old females also had impaired insulin clearance as compared to the Adult group. Aging was associated with physical performance decline together with higher odds of frailty development. There was also age-driven mesangial expansion and glomerular hypertrophy as well as bone mineral density loss. All of the in vivo and in vitro impairments observed with aging co-occurred with upregulation of inflammatory pathways and Myc signaling as well as downregulation of genes related to adipogenesis and oxidative phosphorylation in liver. PDX attenuated the age-driven physical performance (strength, exhaustion, walking speed) decline, promoted robustness, prevented bone losses and partially reversed changes in hepatic expression of Myc targets and metabolic genes. In conclusion, our data provides evidence of the beneficial therapeutic effect of PDX against features of frailty in mice. Further studies are warranted to investigate the mechanisms of action and the potential for human translation.
Medical clowning in hospitalized children: a meta-analysis
Authors: Kasem Ali Sliman Rim , Meiri Noam , Pillar Giora 
Published: April 2023

Abstract
Background
Medical clowning has been proven effective in reducing pain, anxiety, and stress in many sporadic, usually small-scale studies. Our meta-analysis aims to evaluate the efficiency of medical clowns in reducing pain and anxiety in hospitalized pediatric patients and their parents in different medical fields.

Methods
A thorough literature search was conducted from different databases, and only randomized controlled trials (RCTs) were included with children aged 0 to 18 years old. A total of 18 studies were included, and statistical analysis was performed on the combined data.

Results
A total of 912 children (14 studies) showed significantly reduced anxiety when procedures were performed with a medical clown compared with the controls (− 0.76 on anxiety score, P < 0.001). Preoperative anxiety was lower in 512 children (nine studies) with clown interventions than in the controls (− 0.78, P < 0.001). The pain scale was completed by 338 participants (six studies), indicating a trend toward reduced pain during procedures performed while the clown was acting compared to controls (− 0.49, P = 0.06). In addition, medical clown significantly (− 0.52, P = 0.001) reduced parental anxiety in 489 participants in ten studies; in six of the ten studies, with a total of 380 participants, medical clown significantly reduced parental preoperative anxiety (P = 0.02).

Conclusion
Medical clowns have substantial positive and beneficial effects on reducing stress and anxiety in children and their families in various circumstances in pediatrics.
SARS-CoV-2 BW lineage, a fast-growing Omicron variant from southeast Mexico bearing relevant escape mutations
Authors: García-López Rodrigo , Rivera-Gutiérrez Xaira , Rosales-Rivera Mauricio , Zárate Selene , Muñoz-Medina José Esteban , Roche Benjamin , Herrera-Estrella Alfredo , Gómez-Gil Bruno , Sanchez-Flores Alejandro , Taboada Blanca , Arias Carlos F. 
Published: April 2023

Abstract
Purpose
The swift expansion of the BW.1 SARS-CoV-2 variant coincided with a rapid increase of COVID-19 cases occurring in Southeast Mexico in October, 2022, which marked the start of Mexico’s sixth epidemiological wave. In Yucatan, up to 92% (58 of 73) of weekly sequenced genomes between epidemiological week 42 and 47 were identified as either BW.1 or its descendant, BW.1.1 in the region, during the last trimester of 2022. In the current study, a comprehensive genomic comparison was carried out to characterize the evolutionary history of the BW lineage, identifying its origins and its most important mutations.

Methods
An alignment of all the genomes of the BW lineage and its parental BA.5.6.2 variant was carried out to identify their mutations. A phylogenetic and ancestral sequence reconstruction analysis with geographical inference, as well as a longitudinal analysis of point mutations, were performed to trace back their origin and contrast them with key RBD mutations in variant BQ.1, one of the fastest-growing lineages to date.

Results
Our ancestral reconstruction analysis portrayed Mexico as the most probable origin of the BW.1 and BW.1.1 variants. Two synonymous substitutions, T7666C and C14599T, support their Mexican origin, whereas other two mutations are specific to BW.1: S:N460K and ORF1a:V627I. Two additional substitutions and a deletion are found in its descending subvariant, BW.1.1. Mutations found in the receptor binding domain, S:K444T, S:L452R, S:N460K, and S:F486V in BW.1 have been reported to be relevant for immune escape and are also key mutations in the BQ.1 lineage.

Conclusions
BW.1 appears to have arisen in the Yucatan Peninsula in Southeast Mexico sometime around July 2022 during the fifth COVID-19 wave. Its rapid growth may be in part explained by the relevant escape mutations also found in BQ.1.
Comparative study on boundary lubrication of Ti3C2Tx MXene and graphene oxide in water
Authors: Sun Wei , Song Qingrui , Liu Kun , Zhang Qing , Tao Zhensheng , Ye Jiaxin 
Published: April 2023

AbstractThe emerging use of two-dimensional (2D) nanomaterials as boundary lubricants in water offers numerous benefits over oil-based lubricants; whereas the friction reduction varies significantly with nanomaterial type, size, loading, morphology, etc. Graphene oxide (GO) and Ti3C2Tx MXene, a relatively new 2D material, are investigated as boundary lubricants in water in this study. The contact pair mainly includes Si3N4 balls and Si wafer. The results found (1) monodispersed GO offers better lubricity than monodispersed MXene under identical concentration and testing conditions; and (2) the mixed dispersion of GO and MXene (0.1 mg/ml: 0.1 mg/ml) produced the lowest friction coefficient of ∼ 0.021, a value 4× and 10× lower than that produced by comparable mono-dispersions of GO or MXene, respectively. Wear track analysis, focused ion beam microscopy, in-situ contact observation, and atomic force microscopy (AFM) characterization suggest (1) GO nanoflakes have higher adhesion than MXene and are more easily adsorbed on the tribopairs’ surfaces, and (2) GO/MXene tribofilm has a layered nanostructure constituting GO, MXene, amorphous carbon, and TiO2. We further hypothesized that the high lubricity of GO/MXene results from the synergy of GO’s high adhesiveness, MXene’s load support ability, and the low shear strength of both constituents. The present study highlights the key role of tribofilm stability in water-based boundary lubrication using state-of-the-art 2D nanomaterials.
Literature Survey on Automatic Pipe Routing
Authors: Blokland M. , van der Mei R. D. , Pruyn J. F. J. , Berkhout J. 
Published: April 2023

AbstractPiping systems are common in many architectures and designing such systems is often a complex task. Design automation of piping systems is therefore a universal research subject. Nonetheless, these piping systems are often still designed by hand as a result of their complexity. Consequently, costs associated with piping design are high, especially for large-scale architectures like ships and chemical plants. The goal of automatic pipe routing is to reduce the design time and associated costs of a piping system by automating the routing of these pipes. This survey provides an overview of the current state of automatic pipe routing literature to assist researchers and practitioners to further the study of automatic pipe routing. This is done by pinpointing and explaining the most important obstacles that stand in the way of making a full-scale automatic pipe routing method. The barriers that are analyzed are related to both model representation and optimization complexity. Finally, a synthesis table of research papers on automatic pipe routing is provided based on the handling of the aforementioned barriers and other general features of automatic pipe routing methodology. The survey concludes by discussing directions for further research.
Investigation of wind energy speed and power, and its impact of sustainability: Saudi Arabia a model
Authors: Waheeb S. A. , Al-Samarai Riyadh A. , Alias M. F. A. , Al-Douri Y. 
Published: April 2023

AbstractThe study of wind energy is presented in six sites; Sharurah, Jeddah South, Al Wajh, Riyadh, Hafar Al Batin and Al Jouf of Saudi Arabia (KSA) is updated. The wind energy and its status are interpreted. The annual mean values of long-term for wind speeds are varied between the years 2000 and 2020. Also, the wind power density annual values are varied between the years 2006 and 2020. In addition, the speed of winds over whole the geography of KSA is researched. The distribution of percent frequency at different speeds of wind of these six sites at 12 m along two decades ago is presented that could affect on sustainability.