bluuebunny/crossref_metadata_2025_split huggingface dataset:
(256) SEXUALITY AFTER TOTAL ABDOMINAL HYSTERECTOMY FOR BENIGN GYNECOLOGICAL CONDITIONS
Authors: Ons Kaabia , Rim Bouchahda , Raouf Ben Abdesslem , Ryadh Ncibi , Khouloud Ikridih , Hedi Khairi 
Published: July 2023

Abstract

Objectives
Since antiquity, the uterus has been associated with femininity and sexuality in addition to its reproductive function. This work proposes to evaluate the medium-term impact of hysterectomy for a benign pathology on the sexual function of patients.

Methods
This is a descriptive cross-sectional study that included initially non-menopausal women with hysterectomy without abdominal adnexectomy for a benign pathology at our Department, between January 2017 and December 2019. Patients reporting sexual complaints prior to surgery were excluded. A self-administered questionnaire was distributed during the first follow-up visit to confirm the benign nature of the pathology after the anatomopathological examination of the surgical specimens. The female sexual function was evaluated by the questionnaire translated into Arabic and validated that is the Female Sexual Function Index (Ar FSFI).

Results
The study thus recruited 88 patients whose mean age was 48.9 years (from 40 to 55 years). Preoperatively, 50% of the participants had contraception, 60% of which was hormonal. Preoperatively, 40% reported regular sexual activity. Hysterectomies were indicated for myomatous and/or adenomyotic uterus in 88% of cases and for premenopausal metrorrhagia resistant to medical treatment in the other cases. Per and postoperative hemorrhagic complications were reported in 7.84% of cases. Postoperatively, low sexual desire was found in 50%, subjective arousal disorder in 44% of cases, lubrication disorder in 18%, and orgasm disorder in 26%. The overall satisfaction rate was 84%. Dyspareunia was reported in 18% during intercourse versus 12% after intercourse.

Conclusions
Total abdominal hysterectomy without adnexectomy for benign pathology in previously non-menopausal women alters sexual function with essentially a decrease in desire and subjective arousal.

Conflicts of Interest
Nothing to declare.
(172) SEXUAL FUNCTION AND QUALITY OF LIFE IN WOMEN WITH LICHEN SCLEROSUS
Authors: Dr. Hevy S Gibrael , Signe Linhardt , Prof. Christian Graugaard 
Published: July 2023

Abstract

Objectives
Lichen sclerosus (LS) is a chronic inflammatory skin disease that most commonly affects the anogenital region in women. LS can be asymptomatic in some patients. In others, it can lead to irreversible anatomical changes in the vulvar area, such as reabsorption of the labia minora, burial of the clitoris, labial fusion and introital stenosis. Symptoms can include severe itch, paresthesia, and dyspareunia. However, there is a paucity of data concerning the effects of LS on sexual functioning. The aim of this study was to evaluate sexual function and quality of life in women with LS.

Methods
A literature review was performed based on extensive searches in PubMed. References were assessed for relevance by title and abstract by 2 independent reviewers, yielding 14 research papers for inclusion in the study.

Results
Women with LS had significantly decreased sexual activity and less satisfying sexual activity when compared with controls with no history of LS, and this included all types of sexual activity (vaginal, oral, anal and masturbation). Sexual function was significantly reduced among women with LS compared to controls, and this applied for all subdomains (desire, lubrication, arousal, orgasm, and pain). Women with LS had significant worse genital self-image, more anxiety, more depressive symptoms, and impaired health-related quality of life compared to controls. Despite adequate medical treatment, women with LS continued to have significant sexual distress. Sexual distress decreased but did not resolve.

Conclusions
LS can have a considerable impact on sexual function and quality of life. Thus, it is important that healthcare professionals consider LS from a bio-psycho-social perspective, where focus is not restricted to the biological aspects of the disease, but also on its psychosocial ramifications.

Conflicts of Interest
No interest of conflict.
(160) THE ALETTA CLINICAL STUDY: DESIGN OF A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY INVESTIGATING THE EFFICACY AND SAFETY OF LYBRIDOTM IN PREMENOPAUSAL WOMEN WITH ACQUIRED FSIAD
Authors: Prof. Yacov Reisman , Prof. Linda Vignozzi , Prof. Rossella Nappi , Giovanni Corona , Wil den Hollander , Dr. Jan van der Mooren , Prof. Annamaria Giraldi 
Published: July 2023

Abstract

Objectives
Low sexual desire is the most common sexual complaint in women. As a result, many women suffer from sexual dissatisfaction and related distress which often negatively interferes with their quality of life. Currently, limited drug treatments are available globally to treat women with Female Sexual Interest & Arousal Disorder (FSIAD). As a result, there is an unmet need, and relevance to develop a drug treatment for women with sexual dysfunction. LybridoTM (Freya Pharma Solutions, Amsterdam, the Netherlands) is a novel on-demand dual route/dual release fixed dose combination tablet of sublingual testosterone and oral sildenafil. It has shown a promising efficacy and safety profile in Phase 2 and is ready for Phase 3 testing.

Methods
Design: A double-blind, randomized, placebo-controlled, 3-arm, 6-month study to evaluate the efficacy and safety of LybridoTM in premenopausal women with acquired FSIAD. Study Population: European premenopausal women, at least 18 years of age, with a clinical diagnosis of acquired FSIAD. Interventions: The study drug is a fixed-dose combination tablet consisting of an inner core containing sildenafil with an outer delayed immediate release coating and an additional outer film coating containing testosterone. Two dose strengths will be evaluated and compared with placebo.

Results
Outcome Measures: Primary endpoint: change from baseline to Week 24 Female Sexual Function Index Desire Domain (FSFI-D) (Items 1 and 2). Secondary efficacy endpoints: Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO) score; Elements of Desire Questionnaire (EDQ) ‘event-based’; FSFI Arousal Domain (FSFI-A); FSFI total score; FSDS-DOA total score; Sexual Satisfaction of an Event Questionnaire (SSEQ), reported within 24 hours; Patient Global Impression of Improvement (PGI-I) Scale; Patient Global Impression of Severity (PGI-S) Scale; and total number of sexual events. Safety outcomes: frequency of (serious) adverse events.

Conclusions
Study Planning: First Patient In: Q2 2023; Interim Analysis: Q4 2023; Last Patient Out: Q2 2024.

Conflicts of Interest
Study supported by Freya Pharma Solution.
(177) ROLE OF SEXUAL EDUCATION ON INTENTIONAL ABORTION RATE IN IRAN
Authors: Dr. Mohsen Ghorbani , Prof. Mahnoosh Foroughi 
Published: July 2023

Abstract

Objectives
Background: The lack of sex education (due to the religious beliefs in traditional population) is palpable in Iran, which has led to social problems and medical issues. Objectives: The propose of this study was to investigate the role of lack of sex education in the rate of the sexual problems and induced abortions in the last 25 years in Iran

Methods
This retrospective study was designed according to data collection through official statistical data from Legal Medical Organization and Statistical center of Iran during 1995-2020.

Results
Due to the lack of sex education for general population, society’s sexual knowledge is very limited. Sexual health and family planning training have been deleted in the universities. The prevalence of female and male sexual dysfunctions were 67.9% and58.2%, respectively. Overall prevalence has been increased significantly in recent years. Only 1.4 % of induced abortion were legally licensed during this period. The majority of induced abortions are due to unwanted extramarital pregnancies. According to the law, pregnancy outside the marriage is an unforgivable crime in Iran. Considering with 25% decrease in marriage rate and 4.8 fold increase in divorce rate, the rate of intentional abortion has been increased about 5 times.

Conclusions
This study can be considered a model for all similar societies. This study might suggest the importance role of public knowledge about sexual health and family planning from school to university, breaking the taboo of treating sexual problems, and its protective effect for reducing the number of intentional abortions as well as the complications of abortions.

Conflicts of Interest
Our abstract is free from commercial influence or bias.
(106) DEVELOPMENT AND VALIDATION OF ARABIC VERSION OF THE FEMALE SEXUAL DISTRESS SCALE-REVISED (AR-FSDS-R)
Authors: Atia Attaky 
Published: July 2023

Abstract

Objectives
The Female Sexual Distress Scale-Revised (FSDS-R) was developed, and extensively validated globally; none has demonstrated sufficient validity and reliability for use in Arabic populations, particularly women. This study aimed to assess the psychometric Properties of the Female Sexual Distress Scale-Revised (FSDS-R) in the Arabic version and to estimate the optimal cutoff score that corresponds best to the clinical diagnosis of sexual dysfunction.

Methods
The Arabic version of the Female Sexual Distress Scale-Revised (FSDS-R) was generated by two independent professional English-to-Arabic translators. The translated version of the FSDS-R was reverse translated by two bilingual translators whose native language was English. Women with female sexual interest and arousal disorder (n = 100) and those with no symptoms (n = 100) were included in the present study. Correlation analysis conducted between the FSDS-R total score, the Female Sexual Function Index subscale, and the total score was examined for convergent validity.

Results
Construct validity was established via confirmatory factor analysis; Item-total score correlations ranged .78–.92; item-subscale score correlations ranged .58–.88, and subscale-total score correlations ranged .58–.92. Item factor loadings ranged .73–.91. Statistically significant correlations were found between each of these results (p &lt; .001). Cronbach’s alpha was .82 for the complete scale and ranged .78–.92 for subscales. Test-retest reliability over a 2-week period was estimated using intraclass correlation coefficients (ICCs). The test-retest reliability analysis yielded no significant difference (p &lt; .05).

Conclusions
The Arabic version of the Female Sexual Distress Scale-Revised (Ar- FSDS-R) is a valid and reliable instrument that can be used to evaluate the sexual distress of Arabic -speaking women with different sexual problems. A score of ≤12 was proposed as a cutoff to detect the presence of sexually related personal distress in Arabic women with FSD.

Conflicts of Interest
No Conflicts of Interest.
(63) SEXUAL SELF-CONCEPT OF MIDDLE-AGED MEN AND ASSOCIATIONS WITH THEIR SEX LIVES: RESULTS FROM THE BAVARIAN MEN’S HEALTH STUDY
Authors: Christina Passler , Prof. Andreas Dinkel , Dr. Valentin H Meissner , Stefan Schiele , Helga Schulwitz , Prof. Jürgen E Gschwend , Prof. Kathleen Herkommer 
Published: July 2023

Abstract

Objectives
The sexual self-concept is a major component of sexual health. The aim of this study was to investigate associations of different dimensions of the sexual self-concept with sexual activity, sexual satisfaction, and importance of sex-life of German men.

Methods
Included were 2,349 heterosexual men from the Bavarian Men's Health-Study. Parameters of sexual life were “sexual activity within the past three months” (sexual activity), “sexual satisfaction”, and “sexual importance”. We assessed four dimensions of the sexual self-concept, namely “body image”, “masculinity”, “sexual self-esteem”, and “perceived social pressure with regard to sexual performance”. For each dimension, a linear regression model was performed to assess associations with sexual activity, sexual satisfaction, and sexual importance controlling for the sexual parameters with adjustment for sociodemographic characteristics, anxiety and depressive symptoms.

Results
At the time of the survey, 18.7% of the men (mean age 50.4±0.8 years) were sexually active at least 2 times per week, 66.6% at least several times per month and 14.7% reported no sexual activity in the last 3 months. 45.9% reported being (very) satisfied with their sex-life, and 60.9% considered sexuality as (very) important. Higher sexual activity, higher satisfaction, and higher importance were associated with a more positive body image (each p&lt;0.001), and a more positive sexual self-esteem (each p&lt;0.001). Higher sexual activity, higher satisfaction and higher importance were associated with lower perceptions of social pressure (each p&lt;0.01). There was no association between masculinity and sexual activity, sexual satisfaction, and sexual importance.

Conclusions
Higher sexual satisfaction, higher sexual importance, and higher sexual activity were associated with dimensions of the sexual self-concept. Positive perceptions of one's sexuality are associated with a more positive sexual self-concept.

Conflicts of Interest
The authors have no conflict of interest to declare.
(184) THE MEDIA'S ROLE IN SEXUAL AND REPRODUCTIVE HEALTH EDUCATION
Authors: Dr. Abdessamad D S Benalla 
Published: July 2023

Abstract

Objectives
To promote a effective sexual and reproductive health in a conservative muslim countries, the youtube show aims to break taboos and to correct false infiormations and conceptions about sexual lifestyle and diseases.

Methods
Doc Samad Lifestyle show is a daily live free talk show, empowering youth by talking about sexual health issues on their own terms. it connects young people to vital confidential, personalized sexual and reproductive health (SRH) information. Most young people in Arab World countries are in lack to accurate medical sexual information about their sexual wellness without social and religious judgement, thus, Doc Samad show gives the open platform for free counceling and mental coaching.

Results
The show airs daily since 2015, number of emails received is 69280, number of calls received 126488, number of female callers 67776, number of male callers is 58712. Main subjects treated: 47% Vaginism, 32% early ejaculation, 19% sexual orientation troubles. Age rate: 14-18 years old 36%, 18-25 years old. 54%.

Conclusions
Doc Samad Lifestyle show in youtube since 8 years has become an interactive platform for citizens, specifically youth, to express their concerns and satisfy their needs to get scientific information in a joyfull way about sexual and reproductive health in a confidential way, within a cultural and religious context where sexuality is taboo. For informatiom Doc Samad has been beated by Muslims integrist and now live and refugee in Italy.

Conflicts of Interest
No potential conflicts.
(297) THE EFFECT OF PENIS SIZE ON PARTNER SEXUAL SATISFACTION: A LITERATURE REVIEW
Authors: Dr. Shirley Loos , Dr. Sam Ward 
Published: July 2023

Abstract

Objectives
Sexual dysfunctions that men experience due to their anxiety about their penis size may impact their partners’ sexual life as well. In addition, a decrease in sexual satisfaction of a partner caused by an actual pathology in penis size may exacerbate sexual complexities for the couple. Therefore, it is crucial that men and their partners have easy access to reliable information regarding what constitutes normal penile proportions.

Methods
A systematic review of the English (only per reviewed articles) literature was performed on MEDLINE and PubMed to investigate the effect of penis size on partner sexual satisfaction. Keywords including “penis”, “phallus”, “organ size”, “girth”, “circumference”, “length”, “dimension”, “partner”, and “sexual satisfaction” were used to specify searches.

Results
Men who have sex with women All the studies included in this analysis rely on self-reported and non-validated questionnaires, accompanied by small samples and response bias. Therefore, the results of these studies cannot be generalized and further studies are required to elucidate the relationship between penis size and sexual satisfaction of women.
Men who have sex with men In our literature search, we found only one study that evaluated the impact of penis size on partner’s sexual satisfaction. Therefore, current evidence does not allow us to make conclusion on this topic.

Conclusions
It was hypothesized that the choice of a partner during sexual activity was an important component of the sexual selection force that determined the size of the penis. On the other hand, this force has been somewhat ineffective due to the fact that men’s partners do not always perceive the size of their partner’s penis to be the most essential factor in determining the level of sexual satisfaction they experience. Future research needs to test the hypotheses on the relationship between penis size and the sexual satisfaction of the partner.

Conflicts of Interest
no conflicts of interest.
Cataclysmic variables are a key population of gravitational wave sources for LISA
Authors: Scaringi S , Breivik K , Littenberg T B , Knigge C , Groot P J , Veresvarska M 
Published: July 2023

ABSTRACT
The gravitational wave (GW) signals from the Galactic population of cataclysmic variables (CVs) have yet to be carefully assessed. Here, we estimate these signals and evaluate their significance for Laser Interferometer Space Antenna (LISA). First, we find that at least three known systems are expected to produce strong enough signals to be individually resolved within the first four years of LISA’s operation. Secondly, CVs will contribute significantly to the LISA Galactic binary background, limiting the mission’s sensitivity in the relevant frequency band. Third, we predict a spike in the unresolved GW background at a frequency corresponding to the CV minimum orbital period. This excess noise may impact the detection of other systems near this characteristic frequency. Fourth, we note that the excess noise spike amplitude and location associated with Pmin ∼ 80 min can be used to measure the CV space density and period bounce location with complementary and simple GW biases compared to the biases and selection effects plaguing samples selected from electromagnetic signals. Our results highlight the need to explicitly include the Galactic CV population in the LISA mission planning, both as individual GW sources and generators of background noise, as well as the exciting prospect of characterising the CV population through their GW emission.
Ongoing Rapid Evolution of a Post-Y Region Revealed by Chromosome-Scale Genome Assembly of a Hexaploid Monoecious Persimmon (Diospyros kaki)
Authors: Horiuchi Ayano , Masuda Kanae , Shirasawa Kenta , Onoue Noriyuki , Fujita Naoko , Ushijima Koichiro , Akagi Takashi 
Published: July 2023

Abstract
Plants have evolved sex chromosomes independently in many lineages, and loss of separate sexes can also occur. In this study, we assembled a monoecious recently hexaploidized persimmon (Diospyros kaki), in which the Y chromosome has lost the maleness-determining function. Comparative genomic analysis of D. kaki and its dioecious relatives uncovered the evolutionary process by which the nonfunctional Y chromosome (or Ymonoecy) was derived, which involved silencing of the sex-determining gene, OGI, approximately 2 million years ago. Analyses of the entire X and Ymonoecy chromosomes suggested that D. kaki's nonfunctional male-specific region of the Y chromosome (MSY), which we call a post-MSY, has conserved some characteristics of the original functional MSY. Specifically, comparing the functional MSY in Diospyros lotus and the nonfunctional “post-MSY” in D. kaki indicated that both have been rapidly rearranged, mainly via ongoing transposable element bursts, resembling structural changes often detected in Y-linked regions, some of which can enlarge the nonrecombining regions. The recent evolution of the post-MSY (and possibly also MSYs in dioecious Diospyros species) therefore probably reflects these regions’ ancestral location in a pericentromeric region, rather than the presence of male-determining genes and/or genes controlling sexually dimorphic traits.
N-terminal alanine-rich (NTAR) sequences drive precise start codon selection resulting in elevated translation of multiple proteins including ERK1/2
Authors: Buscà Roser , Onesto Cercina , Egensperger Mylène , Pouysségur Jacques , Pagès Gilles , Lenormand Philippe 
Published: July 2023

Abstract
We report the discovery of N-terminal alanine-rich sequences, which we term NTARs, that act in concert with their native 5′-untranslated regions to promote selection of the proper start codon. NTARs also facilitate efficient translation initiation while limiting the production of non-functional polypeptides through leaky scanning. We first identified NTARs in the ERK1/2 kinases, which are among the most important signaling molecules in mammals. Analysis of the human proteome reveals that hundreds of proteins possess NTARs, with housekeeping proteins showing a particularly high prevalence. Our data indicate that several of these NTARs act in a manner similar to those found in the ERKs and suggest a mechanism involving some or all of the following features: alanine richness, codon rarity, a repeated amino acid stretch and a nearby second AUG. These features may help slow down the leading ribosome, causing trailing pre-initiation complexes (PICs) to pause near the native AUG, thereby facilitating accurate translation initiation. Amplification of erk genes is frequently observed in cancer, and we show that NTAR-dependent ERK protein levels are a rate-limiting step for signal output. Thus, NTAR-mediated control of translation may reflect a cellular need to precisely control translation of key transcripts such as potential oncogenes. By preventing translation in alternative reading frames, NTAR sequences may be useful in synthetic biology applications, e.g. translation from RNA vaccines.
Shifting Sociodemographic Characteristics of a Phase I Clinical Trial Population at an NCI-Designated Comprehensive Cancer Center in the Southeast
Authors: Lalonde Chloe S , Switchenko Jeffrey M , Behera Madhusmita , Bilen Mehmet A , Owonikoko Taofeek K , Kaufman Jonathan L , Nooka Ajay K , Lewis Colleen M , Hitron Elise , Collins Hannah , Judson Emma C , Alese Olatunji B , Donald Harvey R , Carlisle Jennifer W 
Published: July 2023

Abstract
Racial and ethnic minority populations are consistently under-represented in oncology clinical trials despite comprising a disproportionate share of a cancer burden. Phase I oncology clinical trials pose a unique challenge and opportunity for minority inclusion. Here we compared the sociodemographic characteristics of patients participating in phase 1 clinical trials a National Cancer Institute ( NCI)-designated comprehensive center to all patients at the center, patients with new cancer diagnosis in metropolitan Atlanta and patients with new cancer diagnoses in the state of Georgia. From 2015 to 2020, 2325 patients (43.4% female, 56.6% male) consented to participate in a phase I trial. Grouped self-reported race distribution was 70.3% White, 26.2% Black, and 3.5% other. Of new patient registrations at Winship Cancer Institute (N = 107 497) (50% F, 50% M), grouped race distribution was 63.3% White, 32.0% Black, and 4.7% other. Patients with new cancer diagnoses in metro Atlanta from 2015 to 2016 (N = 31101) were 58.4% White, 37.2% Black, and 4.3% other. Race and sex distribution of phase I patients was significantly different than Winship patients (P &lt; .001). Over time, percent of White patients decreased in both phase I and Winship groups (P = .009 and P &lt; .001, respectively); percentage of females did not change in either group (P = .54 phase I, P = .063 Winship). Although phase I patients were more likely to be White, male, and privately ensured than the Winship cohort, from 2015 to 2020 the percentage of White patients in phase I trials and among all new patients treated at Winship decreased. The intent of characterizing existing disparities is to improve the representation of patients from racial and ethnic minority backgrounds in phase I clinical trials.