bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Delivery of siRNA Using Fluorinated, Small‐Sized Nanocapsules toward Anti‐Inflammation Treatment
Authors: Wei Yuansong , Li Xudong , Lin Juanhui , Zhou Yang , Yang Jiandong , Hou Mengying , Wu Fan , Yan Jing , Ge Chenglong , Hu Duanmin , Yin Lichen 
Published: December 2022

AbstractOral delivery of small interfering RNA (siRNA) provides a promising paradigm for treating diseases that require regular injections. However, the multiple gastrointestinal (GI) and systemic barriers often lead to inefficient oral absorption and low bioavailability of siRNA. Technologies that can overcome these barriers are still lacking, which hinders the clinical potential of orally delivered siRNA. Herein, small‐sized, fluorinated nanocapsules (F‐NCs) are developed to mediate efficient oral delivery of tumor necrosis factor α (TNF‐α) siRNA for anti‐inflammation treatment. The NCs possess a disulfide‐cross‐linked shell structure, thus featuring robust stability in the GI tract. Because of their small size (≈30 nm) and fluorocarbon‐assisted repelling of mucin adsorption, the best‐performing F3‐NCs show excellent mucus penetration and intestinal transport capabilities without impairing the intestinal tight junction, conferring the oral bioavailability of 20.4% in relative to intravenous injection. The disulfide cross‐linker can be cleaved inside target cells, causing NCs dissociation and siRNA release to potentiate the TNF‐α silencing efficiency. In murine models of acute and chronic inflammation, orally delivered F3‐NCs provoke efficient TNF‐α silencing and pronounced anti‐inflammatory efficacies. This study therefore provides a transformative strategy for oral siRNA delivery, and will render promising utilities for anti‐inflammation treatment.
TRAPPC9‐related neurodevelopmental disorder: Report of a homozygous deletion in TRAPPC9 due to paternal uniparental isodisomy
Authors: Penon‐Portmann Monica , Hodoglugil Ugur , Arun P Wiita , Yip Tiffany , Slavotinek Anne , Tenney Jessica L. 
Published: December 2022

AbstractTRAPPC9 loss‐of‐function biallelic variants are associated with an autosomal recessive intellectual disability syndrome (Online Mendelian Inheritance of Man no. 613192), also characterized by microcephaly, hypertelorism, obesity, growth delay, and behavioral differences. Here, we describe an 8‐year‐old Hispanic female with neurodevelopmental disorder, partial epilepsy, microcephaly, bilateral cleft lip and alveolus, growth delay, and dysmorphic features. She had abnormal myelination, mega cisterna magna, and colpocephaly on brain magnetic resonance imaging (MRI). Microarray showed a single ~146 Mb region of homozygosity (ROH) encompassing all of Chromosome 8, consistent with uniparental isodisomy (UPD). Exome sequencing performed in‐house did not identify single nucleotide variants to explain her phenotype. Algorithms developed in‐house and further evaluation of BAM files revealed a homozygous deletion overlapping Exon 2 in TRAPPC9 within the ROH. Subsequent del/dup analyses with exon‐level oligo array confirmed a likely pathogenic deletion in TRAPPC9 (NM_031466.5): arr[GRCh37] 8q24.3(141460661_141461780)x0. Our case highlights the implications of downstream analyses from UPD/ROH given the increased risk for AR conditions, the strengths of combining orthologous molecular methods to establish a diagnosis and further delineates the TRAPPC9‐related phenotype in an individual of Hispanic ancestry.
Superconductivity in an Orbital‐Reoriented SnAs Square Lattice: A Case Study of Li0.6Sn2As2 and NaSnAs
Authors: Wang Junjie , Ying Tianping , Deng Jun , Pei Cuiying , Yu Tongxu , Chen Xu , Wan Yimin , Yang Mingzhang , Dai Weiyi , Yang Dongliang , Li Yanchun , Li Shiyan , Iimura Soshi , Du Shixuan , Hosono Hideo , Qi Yanpeng , Guo Jian‐gang 
Published: December 2022

AbstractSearching for functional square lattices in layered superconductor systems offers an explicit clue to modify the electron behavior and find exotic properties. The trigonal SnAs3 structural units in SnAs‐based systems are relatively conformable to distortion, which provides the possibility to achieve structurally topological transformation and higher superconducting transition temperatures. In the present work, the functional As square lattice was realized and activated in Li0.6Sn2As2 and NaSnAs through a topotactic structural transformation of trigonal SnAs3 to square SnAs4 under pressure, resulting in a record‐high Tc among all synthesized SnAs‐based compounds. Meanwhile, the conductive channel transfers from the out‐of‐plane pz orbital to the in‐plane px+py orbitals, facilitating electron hopping within the square 2D lattice and boosting the superconductivity. The reorientation of p‐orbital following a directed local structure transformation provides an effective strategy to modify layered superconducting systems.
Tuning the CO2 Hydrogenation Selectivity of Rhodium Single‐Atom Catalysts on Zirconium Dioxide with Alkali Ions
Authors: Li Shang , Xu Yuxing , Wang Hengwei , Teng Botao , Liu Qin , Li Qiuhua , Xu Lulu , Liu Xinyu , Lu Junling 
Published: December 2022

AbstractTuning the coordination environments of metal single atoms (M1) in single‐atom catalysts has shown large impacts on catalytic activity and stability but often barely on selectivity in thermocatalysis. Here, we report that simultaneously regulating both Rh1 atoms and ZrO2 support with alkali ions (e.g., Na) enables efficient switching of the reaction products from nearly 100 % CH4 to above 99 % CO in CO2 hydrogenation in a wide temperature range (240–440 °C) along with a record high activity of 9.4 molCO gRh−1 h−1 at 300 °C and long‐term stability. In situ spectroscopic characterization and theoretical calculations unveil that alkali ions on ZrO2 change the surface intermediate from formate to carboxy species during CO2 activation, thus leading to exclusive CO formation. Meanwhile, alkali ions also reinforce the electronic Rh1‐support interactions, endowing the Rh1 atoms more electron deficient, which improves the stability against sintering and inhibits deep hydrogenation of CO to CH4.
Phase Transformation of VO2/rGO Composites as High‐Voltage Cathodes in Zinc‐Ion Batteries
Authors: Li Yuying , Wang Jingyi , Tian Zhihong , Lai Feili , Liu Tianxi , He Guanjie 
Published: December 2022

AbstractAqueous zinc‐ion batteries (ZIBs) are becoming widely concerned candidates as stationary and safe energy storage technology. Vanadium oxides display promising role as cathodes for ZIBs owing to their inherent merits in structures and multiple valence states. However, their unsatisfactory electrical conductivity and narrow voltage window hinder the practical application. Moreover, the charge storage mechanism at the high voltage is unclear. Herein, we synthesized VO2/rGO composites with high electrical conductivity and demonstrated an electrochemically induced phase transition from tunneled VO2/rGO to Zn3(OH)2V2O7 ⋅ 2H2O/rGO with a laminated structure and an enhanced interlayer spacing during the first charge to 1.6 V, which shows preferable Zn2+ storage capacity. Concretely, the electrochemical window of as‐assembled ZIB expands to 1.6 V with a specific capacity of 329.9 mAh g−1 at 0.1 A g−1, exhibiting wider window compared with the ZIBs based vanadium oxide reported previously. Simultaneously, a long stable lifetime of 84 % capacity retention over 1,000 cycles can be recorded. Our work opens a new idea of design strategy to develop high‐voltage ZIBs.
Oncology distress screening within predominately Black Veterans: Outcomes on supportive care utilization, hospitalizations, and mortality
Authors: Azizoddin Desiree R. , Allsop Matthew , Farah Subrina , Salim Farah , Hauser Joshua , Baltazar Ashton R. , Molokie Robert , Weber Jane , Weldon Christine , Feldman Lawrence , Martin Joanna L. 
Published: December 2022

AbstractBackgroundWe evaluated whether patients' initial screening symptoms were related to subsequent utilization of supportive care services and hospitalizations, and whether patient‐level demographics, symptoms, hospitalizations, and supportive care service utilization were associated with mortality in primarily low‐income, older, Black Veterans with cancer.MethodsThis quality improvement project created collaborative clinics to conduct cancer distress screenings and refer to supportive care services at an urban, VA medical center. All patients completed a distress screen with follow‐up screening every 3 months. Supportive care utilization, hospitalization rates, and mortality were abstracted through medical records. Poisson regression models and cox proportional hazard models were utilized.ResultsFive hundred and eighty five screened patients were older (m = 72), mostly Black 70% (n = 412), and had advanced cancer 54%. Fifty‐eight percent (n = 340) were screened only once with 81% (n = 470) receiving ≥1 supportive care service and 51.5% (n = 297) being hospitalized ≥1 time 18 months following initial screen. Symptom severity was significantly related to number of hospitalizations. Low mood was significantly related to higher supportive services (p < 0.001), but not hospitalizations (p ≥ 0.52). Pain, fatigue, physical function, nutrition, and physical symptoms were significantly associated with more supportive services and hospitalizations (p < 0.01). Twenty percent (n = 168) died; Veterans who were Black, had lower stage cancers, better physical health, and utilized less supportive care services had lower odds of mortality (p ≤ 0.01).ConclusionIndividuals with elevated distress needs and those reporting lower physical function utilized more supportive care services and had higher hospitalization rates. Lower physical function, greater supportive care use, higher stage cancer, and being non‐Black were associated with higher odds of death.
Direct oral anticoagulant versus antiplatelet therapy following transcatheter aortic valve replacement in patients without prior or concurrent indication for anticoagulation: A meta‐analysis of randomized studies
Authors: Barbosa Moreira Matheus José , Peixoto Natália Araújo do Amaral , Udoma‐Udofa Ofonime Chantal , de Lucena Silva Araújo Sílvia , Enriquez Shirley Katherine Tinajero 
Published: December 2022

AbstractIntroductionThe antithrombotic management following transcatheter aortic valve replacement (TAVR) in patients who do not have a concurrent indication for long‐term anticoagulation therapy is an ongoing source of debate.MethodsWe performed a systematic review and meta‐analysis to compare direct oral anticoagulants (DOACs) versus antiplatelet therapy after TAVR in patients without a concomitant indication for chronic oral anticoagulation. PubMed, Embase, and Cochrane databases were searched. Only randomized controlled trials were included. Risk ratios (RR) with p < 0.05 were considered statistically significant.ResultsThree studies were included, with 2922 patients who underwent TAVR, of whom 1463 (50.1%) received DOACs. Patients who received DOACs therapy had significantly higher all‐cause mortality (RR: 1.68; 95% confidence intervals [CI]: 1.22−2.30; p = 0.001) and non‐cardiovascular mortality (RR: 2.33; 95% CI: 1.13−4.80; p = 0.02). The incidence of major bleeding was not significantly different between the groups (5.3% vs. 3.8%; RR: 1.44; 95% CI: 0.90−2.32; p = 0.13). There was no difference between DOACs and antiplatelet therapy in terms of: ischemic stroke (RR: 1.28; 95% CI: 0.76−2.15; p = 0.35) and cardiovascular mortality (RR: 1.36; 95% CI: 0.92−2.03; p = 0.13). Lastly, the DOACs group had a significantly lower risk of valve thrombosis than the antiplatelet group (0.8% vs. 3.2%; RR: 0.27; 95% CI: 0.14−0.51; p < 0.0001).ConclusionIn this meta‐analysis of randomized studies comparing DOACs to antiplatelet therapy after TAVR in patients without a concomitant indication for anticoagulation, DOACs were associated with a lower incidence of valve thrombosis and a higher rate of all‐cause mortality, driven by an increase in noncardiac causes of death.
Endoscopic resection of Intralabyrinthine Schwannoma followed by Cochlear implantation
Authors: Lohnherr Vera , Anschuetz Lukas , Mantokoudis Georgios , Caversaccio Marco , Weder Stefan 
Published: December 2022

AbstractWe present the case of a 65 years old patient who developed a complete, sensorineural hearing loss on the right side due to an intravestibular schwannoma. Our video shows a transcanal, endoscopic approach with complete schwannoma removal on the right side, subsequent e‐BERA recordings, and cochlear implantation.
Small volume biopsy diagnostic yield at initial diagnosis versus recurrence/transformation of follicular lymphoma: A retrospective Cyto‐Heme Interinstitutional Collaborative study
Authors: Fitzpatrick Megan J. , Sundaram Vandana , Ly Amy , Abramson Jeremy S. , Balassanian Ronald , Cheung Matthew C. , Cook Stephen L. , Falchi Lorenzo , Frank Annabel K. , Gupta Srishti , Hasserjian Robert P. , Lin Oscar , Long Steven R. , Menke Joshua R. , Mou Eric , Reed Daniel R. , Ruiz‐Cordero Roberto , Volaric Ashley K. , Wang Linlin , Wen Kwun Wah , Xie Yi , Zadeh Sara L. , Gratzinger Dita 
Published: December 2022

AbstractBackgroundFew studies have evaluated diagnostic yield of small volume biopsies (SVB) for the diagnosis and management of follicular lymphoma (FL).MethodsThe authors performed a multi‐institutional retrospective analysis of SVBs including fine‐needle aspiration (FNA) and needle core biopsy (NCB) for initial FL diagnosis and suspected recurrence or transformation of FL. A total of 676 workups beginning with SVB were assessed for the mean number of biopsies per workup, the proportion of workups requiring multiple biopsies, and the proportion with a complete diagnosis including grade, on initial biopsy.ResultsCompared to workups performed for question transformation/recurrence, those done for initial FL diagnosis were significantly more likely to require multiple biopsies (p < .01), had a higher mean number of biopsies per workup (1.7 vs. 1.1, absolute standardized difference = 1.1), and a lower complete diagnosis rate at initial biopsy (39% vs. 56%). At initial FL diagnosis, NCB +/− FNA was associated with fewer biopsies per workup compared to FNA +/− CB (1.2 vs. 1.9), fewer workups requiring multiple biopsies (23% vs. 83%), and a higher complete diagnosis rate (71% vs. 18%). In contrast, during assessment for transformation/recurrence, NCB and FNA showed a similar mean number of biopsies per workup (1.2 vs. 1.2) and few workups required multiple biopsies (6% vs. 19%).ConclusionsSVB at initial FL diagnosis often required additional biopsies to establish a complete diagnosis. In contrast, when assessing for transformed/recurrent FL, additional biopsies were generally not obtained regardless of SVB type, suggesting that in these clinical settings SVB may be sufficient for clinical decision‐making.
Neuroendocrine tumor of the breast showing invasive micropapillary features and multiple lymph node metastases
Authors: Kawasaki Tomonori , Tashima Tomoaki , Muramatsu Chisako , Fujimoto Akihiro , Usami Yoko , Kodama Hitomi , Ichikawa Jiro , Nagai Hirokazu , Taniyama Kiyomi 
Published: December 2022

AbstractBackgroundHerein, for the first time, we present a case with mixed invasive micropapillary and neuroendocrine mammary neoplasm.CaseThe patient, a 65‐year‐old postmenopausal woman, had become aware of a tumor in her right breast 11 months prior to presentation at our hospital. The cut surface of the mastectomy specimen contained a well‐circumscribed, multinodular, red‐brown tumor, measuring 15x15x15 cm. Histopathologically, this solid cystic lesion consisted of medullary growth of cancer cells accompanied by a well‐developed vascular network as well as conspicuous hemorrhage. Cancer cell nests of various sizes displayed an “inside‐out” structure surrounded by empty spaces. Most cancer cells were polygonal, though a few were short fusiform‐shaped, and possessed finely granular, eosinophilic cytoplasm and ovoid, fine‐granular nuclei. Eighteen mitotic figures were observed in 10 high‐power fields. Macrometastases, up to 13x8 mm in size, with the same morphological features as the original tumor site, were identified in 3 of 15 dissected right axillary nodes. Immunohistochemically, primary and metastatic cancer cells were diffusely positive for chromogranin A and the estrogen receptor (Allred's total score: 8) and focally reactive for synaptophysin and the progesterone receptor (total score: 5). HER2 and cytokeratin 5/6 were negative, and the MIB‐1 labelling index was 36.2%. MUC1 and EMA lined the stroma‐facing surfaces of the cell membranes, indicating reversed polarity.ConclusionOur current patient, who had an invasive breast carcinoma with concomitant neuroendocrine and micropapillary features, developed multiple nodal metastases in association with a large‐diameter tumor showing a luminal B‐like immuno‐profile. Accordingly, meticulous clinical follow‐up remains essential for this uncommon case.
Feeding and developmental outcomes after neonatal seizures—A prospective observational study
Authors: Roberts Katelyn H. , Barks John D. E. , Glass Hannah C. , Soul Janet S. , Chang Taeun , Wusthoff Courtney J. , Chu Catherine J. , Massey Shavonne L. , Abend Nicholas S. , Lemmon Monica E. , Thomas Cameron , Guillet Ronnie , Rogers Elizabeth E. , Franck Linda S. , McCaffery Harlan , Li Yi , McCulloch Charles E. , Shellhaas Renée A. 
Published: December 2022

AbstractObjectiveAmong neonates with acute symptomatic seizures, we evaluated whether the inability to take full feeds at the time of hospital discharge from neonatal seizure admission is associated with worse neurodevelopmental outcomes, after adjusting for relevant clinical variables.MethodsThis prospective, nine‐center study of the Neonatal Seizure Registry (NSR) assessed characteristics of infants with seizures, including evidence of brainstem injury on magnetic resonance imaging (MRI), mode of feeding upon discharge, and developmental outcomes at 12, 18, and 24 months. The inability to take oral feeds was identified through a review of medical records. Brainstem injury was identified through a central review of neonatal MRIs. Developmental outcomes were assessed with the Warner Initial Developmental Evaluation of Adaptive and Functional Skills (WIDEA‐FS) at 12, 18, and 24 months corrected age.ResultsAmong 276 infants, inability to achieve full oral feeds was associated with lower total WIDEA‐FS scores (160.2 ± 25.5 for full oral feeds vs. 121.8 ± 42.9 for some/no oral feeds at 24 months, p < 0.001). At 12 months, a gastrostomy tube was required for 23 of the 49 (47%) infants who did not achieve full oral feeds, compared with 2 of the 221 (1%) who took full feeds at discharge (p < 0.001).ConclusionsThe inability to take full oral feeds upon hospital discharge is an objective clinical sign that can identify infants with acute symptomatic neonatal seizures who are at high risk for impaired development at 24 months.
Application of a hyperspectral camera for colorimetric measurements on polychrome surfaces in a controlled environment and evaluation of three image processing software for displaying colorimetric data: Pros and cons of the methodology presented
Authors: Cherubini Filippo , Casini Andrea , Cucci Costanza , Picollo Marcello , Stefani Lorenzo 
Published: December 2022

AbstractThis work explores the potential of a compact hyperspectral camera, Specim IQ, for the remote colorimetric study of polychrome surfaces in controlled environments. These measurements are generally made with dedicated instruments, such as colorimeters or spectrophotometers, which require contact with the surface and coverage areas of the order of 10s of mm2. These two characteristics, contact and a very small analysis area, can severely limit the study of polychrome surfaces, since the measured areas are not necessarily representative of the entire surface. In addition, it is not always possible to touch the objects being analyzed. A possible alternative is the use of compact hyperspectral cameras, such as Specim IQ, for the in situ study of the spectral and colorimetric characteristics of these surfaces. To better address this research, which is still in the preliminary phase, a 2 × 45°/0° geometry measuringement was used. The illumination of the image plane at 45° with respect to the camera made it possible to eliminate the components reflected specularly on the camera lens. With this shooting geometry, Labsphere Color and Gray Reflectance Standards (eight color and four gray standards) were analyzed and placed on seven different color backgrounds. With the spectral data acquired, it was possible to calculate the color of the targets and display the colorimetric values by means of three commonly used image processing software packages. In this way, it was possible to define for this hyperspectral camera a measurement‐data processing procedure applicable to measurements in the laboratory aimed at studying the color of polychrome surfaces.
Divergent Total Synthesis of Fornicin A, Fornicin D, and Ganodercin D, Meroterpenoids from Ganoderma Mushrooms
Authors: Bunt Daan V. , Aidy Sahar El , Minnaard Adriaan J. 
Published: December 2022

AbstractThe meroterpenoids fornicin A, fornicin D, and ganodercin D, found in mushrooms of the Ganoderma genus, have been prepared in a concise and divergent synthesis route. The characteristic unsaturated γ‐ketoacid moiety was obtained via an optimized step‐wise aldol condensation between two readily accessible building blocks. THP‐protection of a phenolic hydroxyl group under basic conditions was developed, a protocol that adds to the versatility of this protecting group.
A scalable compressible volume of fluid solver using a stratified flow model
Authors: Sementilli Mae L. , McGurn Matthew T. , Chen James 
Published: December 2022

AbstractIn this paper, a Volume of Fluid method which uses a Stratified Flow model for flux calculation is proposed to solve a compressible multiphase flow in a way that has high parallel efficiency. The solver is part of an open‐source computing tool to study fuel entrainment and combustion in the application of paraffin‐based hybrid rocket motors. This paper focuses on the compressible Volume of Fluid solver for the liquid and gaseous phases in this environment. This solver uses perfect gas and stiffened gas models for equation of state, with the ability to easily add other models as desired. Additionally a comparison of a Riemann solver versus an AUSM+up scheme is conducted, showing improvement with the later in the solution of multiphase flows. This solver successfully reproduces shock tube cases with the expected accuracy, as well as simulating two‐dimensional shear and gravity‐driven flows. Results also show that the code is able to utilize a Stratified Flow model to evaluate shear flow without the need for interface reconstruction or gradient calculations. Finally, it is shown that the solver has near‐ideal scaling under strong scaling tests as well as good performance in static scaling, giving improved performance over current options and implying future advancement of high‐performance computing efficiency for multiphase flow solvers.