bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryoablation in the Treatment of Onco-urology Patients with Oligometastatic Bone Lesions
Authors: Прохоров Георгий Георгиевич , Буровик Илья Александрович , Носов Александр Константинович , Прохоров Денис Георгиевич , Щекутеев Никита Андреевич , Беркут Мария Владимировна 
Published: January 2025

Введение. Частота олигометастатического поражения костей скелета в онкоурологии может варьировать в зависимости от типа рака и стадии заболевания: при раке предстательной железы и почки олигометастазы в кости скелета могут быть обнаружены у 20-30 % пациентов при первичном обращении и гораздо реже при уротелиальном раке. Паллиативное применение метастаз-направленной терапии в виде чрескожной криоаблации олигометастазов направлено на контроль болевого синдрома и улучшение качества жизни пациентов.
Цель. Изучение влияния миниинвазивной чрескожной криоаблации, выполняемой в условиях КТ-навигации, на уровень болевого синдрома у больных онкоурологического профиля с олигометастатическим поражением костей.
Материалы и методы. За период с 2019 по 2023 гг. в НМИЦ онкологии им. Н.Н. Петрова проведена чрескожная криоаблация костных олигометастазов у 27 пациентов при прогрессировании рака предстательной железы, почки и мочевого пузыря. Показаниями к операции рассматривали возможность достижения полной циторедукции единичных клинически значимых метастазов костей скелета (олигометастаз) и/или наличие некупируемого болевого синдрома вследствие вовлечения или сдавления нервных стволов с расстройствами чувствительности и движений. Процедуру мини-инвазивной чрескожной пункционной стереотаксической криоаблации выполняли в условиях КТ-навигации под наркозом с использованием Российской мини-инвазивной криохирургической системой «МКС» под контролем КТ- визуализации и прямой термометрии зоны охлаждения.
Результаты. Контрольное обследования 20 (74,0 %) пациентов через один год после метастаз-направленной терапии показало полную девитализацию соответствующих метастатических очагов. У пяти пациентов были выполнены повторные процедуры последовательно по мере появления метахронных метастазов. Качество жизни больных на протяжении всего периода наблюдения оставалось удовлетворительным. У семи пациентов после паллиативной противоболевой криоаблации с исходной болью на уровне 4–8 баллов по визуальной аналоговой шкале болевой синдром был купирован полностью, у остальных существенно снизился.
Выводы. Мини-инвазивная стереотаксическая криоаблация позволяет девитализировать внутрикостные очаги и может рассматриваться в качестве паллиативного лечения больных онкоурологического профиля для устранения локального болевого синдрома при олигометастазах.
Evaluation of the Efficacy of Second-Line Therapy for Metastatic Gastric Cancer in Real Clinical Practice - the Results of a Multicenter Retrospective Study: Experience of Moscow Oncology Service
Authors: Семёнов Николай Николаевич , Федянин Михаил Юрьевич , Хатьков Игорь Евгеньевич , Жукова Людмила Григорьевна , Строяковский Даниил Львович , Покатаев Илья Анатольевич 
Published: January 2025

Введение. В настоящее время во II линии лечения метастатического рака желудка используются различные комбинации лекарственных препаратов.
Цель. Сравнить выживаемость без прогрессирования (ВБП) и общую выживаемость (ОВ) у пациентов метастатическим раком желудка, получавших различные варианты терапии во II линии лечения.
Материалы и методы. Из регистра Москвы выделено 384 пациента с морфологически подтвержденным метастатическим раком желудка, у которых было зафиксировано прогрессирование на фоне проведения I линии лечения. Сформированы 3 группы: получавшие терапию ингибиторами контрольных точек иммунитета (ИКТ) (n = 93), химиотерапию (х/т) (n = 82) и химиотерапию + рамуцирумаб (х/т + раму) (n = 208). Лечение проводилось с 2018 по 2023 гг. Медиана времени наблюдения составила 35,8 мес.
Результаты. В общей группе отмечено преимущество по ВБП у больных, получавших ИКТ и х/т + раму (4,3 мес. и 5,1 мес. соответственно), по сравнению с группой х/т (4,0 мес., р = 0,019 и 0,056 соответственно). ОВ во всех трех группах не различалась (ИКТ — 8,5 мес., х/т — 10,1 мес., х/т + раму — 10,7 мес., р = 0,4 и 0,43, в сравнении с группой х/т). Уровень CPS не влиял на эффективности в группе ИКТ (ВБП при CPS 0-9 — 3,9 мес. при CPS≥10 — 4,2 мес., р = 0,61; ОВ 6,6 мес. и 6,9 мес. соответственно, р = 0,875). При наличии MSI (n = 27) в группе ИКТ в сравнении с MSS ВБП была 11,1 мес. против 3,9 мес., р = 0,068, ОВ — 14,2 мес. против 5,4 мес., р = 0,162. При сравнении с больными с MSI, получавших х/т + раму (n = 14) эти различия нивелировались (ВБП — 11,1 мес. и 3,8 мес., р = 0,13, ОВ — 14,2 мес. и 16,0 мес., р = 0,75). В группах х/т + раму использование двух цитостатиков в сравнении с монотерапией улучшало ВБП, но не ОВ (ВБП — 5,8 мес. и 4,0 мес., р = 0,009, ОВ — 10,8 и 10,1 мес., р = 0,79). При проведении псевдорандомизации отмечено сохранение результатов, полученных в общей группе.
Выводы. Дублетные комбинации, добавление рамуцирумаба или использование ИКТ не продемонстрировали улучшение результатов в сравнении с монохимиотерапией.
The fundamentals of eye tracking part 3: How to choose an eye tracker
Authors: Nyström Marcus , Hooge Ignace T. C. , Hessels Roy S. , Andersson Richard , Hansen Dan Witzner , Johansson Roger , Niehorster Diederick C. 
Published: January 2025

Abstract
There is an abundance of commercial and open-source eye trackers available for researchers interested in gaze and eye movements. Which aspects should be considered when choosing an eye tracker? The paper describes what distinguishes different types of eye trackers, their suitability for different types of research questions, and highlights questions researchers should ask themselves to make an informed choice.
Factores de riesgo y factores protectores de lesión de vía biliar, revisión sistemática
Authors: Ramón Brito Maricela Susana , Muñoz Bonilla Gabriela Alexandra , Hidalgo Brito Jenniffer Dennisse , Delgado Melgar José Miguel , Saveedra Neira María Fernanda 
Published: January 2025

Introducción: Las lesiones iatrogénicas de las vías biliares pueden dejar complicaciones irreversibles como estenosis biliar, atrofia hepática, colangitis, litiasis intrahepática, fibrosis o cirrosis secundaria, colangitis recurrentes y finalmente daño hepatobiliar con complicaciones multiorgánicas. Objetivo general: Analizar mediante una revisión sistemática los factores de riesgo y factores protectores para lesiones de la vía biliar. Metodología: Se utilizó el método PRISMA para la búsqueda de información de artículos referentes a la Prevención de lesión de vía biliar, en bases de datos de Scopus, PubMed, ProQuest, Web of science en el intervalo del 2018-2023. Resultados: En la presente revisión se constató que no existe un solo factor de riesgo y un solo factor protector para lesión de la vía biliar, sino más bien existen varios parámetros que se deben de tomar en cuenta al momento de realizar una colecistectomía ya sea abierta o laparoscópica. Conclusión: Se concluye que en los pacientes sometidos a colecistectomía laparoscópica o abierta es importante tomar en cuenta que los cirujanos utilice la visión crítica de seguridad (CVS) para la identificación anatómica del conducto cístico y la arteria, cuando esta no se pueda visualizar es influyente utilizar con otros métodos (p. ej., imágenes) como refuerzo.
Incidencia de Enfermedad Renal No Detectada en Pacientes con Condición de Diabetes Adscritos al Programa CADIMSS de la Unidad de Medicina Familiar No. 9 en Acapulco, México
Authors: Nieves Espino Alejandra , Barbosa Castañeda Francisco , Sosa Martínez María de Jesús 
Published: January 2025

Antecedentes. La enfermedad renal diabética constituye la primera causa de enfermedad renal crónica y sustitución de la función renal, esto debido al acelerado deterioro de la función renal sufrido por los pacientes que presentan descontrol glucémico, así como, las comorbilidades asociadas que contribuyen como factores de progresión adicionales. Objetivo. Determinar la incidencia de enfermedad renal no detectada y factores relacionados en pacientes con condición de diabetes adscritos al programa CADIMSS de la UMF No. 9. Material y métodos. Estudio transversal, analítico, realizado de junio-noviembre 2023 en 525 pacientes en condición de DM2 inscritos al programa CADIMSS de la UMF No. 9. La fuente de información fue el expediente clínico electrónico y base de datos de laboratorio. Resultados: El 67.8% de la población de estudio presentó descontrol glucémico. La incidencia de enfermedad renal no detectada fue del 3%, la cual se asoció significativamente a tener ≥60 años de edad (OR 4.93, IC95% 1.38-17.52, p 0.006). Conclusiones: Tres de cada cien pacientes presentó enfermedad renal no detectada, asociado con la edad, por lo cual la detección temprana de ERC por diabetes es posible mediante la búsqueda intencionada por parte del personal de salud, que permita otorgar un abordaje integral multidisciplinario.
Eight New Candidate Multiplanet Systems among TESS Objects of Interest
Authors: Munavar Hussain Mohamed Jassim , Kunimoto Michelle 
Published: January 2025

Abstract
We present a search of the TESS Object of Interest (TOI) Catalog for new multiplanet systems. We perform a Box Least Squares search on light curves prepared by the Quick-Look Pipeline to recover known candidates and perform a targeted search for additional candidates in each system. Following vetting and manual inspection, we present eight new planet candidates in multiplanet systems. Highlighted systems include TOI-2037 and TOI-6543, each displaying a nearness to a 2:1 orbital resonance. Four candidates in the TOI-5624 system, including our candidate TIC 53498154.02, have gained TOI status. If confirmed, the TOI-5624 system becomes the 29th known five-planet system. Our identification of candidate TIC 302305400.02 in the TOI-5487 system presents an interesting case study for the formation of hot Jupiter systems, potentially marking the first known system harboring a close-in giant outer companion to an existing hot Jupiter.
Can Active Galactic Nuclei Activity Be Enhanced by Ram Pressure Stripping?—X-Ray Perspective
Authors: Tiwari Juhi , Sun Ming , Luo Rongxin , Fossati Matteo , J. Chen Chien-Ting , Tamhane Prathamesh 
Published: January 2025

Abstract
Ram pressure stripping (RPS) is an important process that plays a significant role in shaping the evolution of cluster galaxies and their surrounding environment. Despite its recognized significance, the potential connection between RPS and active galactic nuclei (AGN) activity in cluster galaxies remains poorly understood. Recent claims, based on optical emission-line diagnostics, have suggested such a connection. Here, we investigate this relationship from an X-ray perspective, using a sample of galaxies undergoing RPS in four nearby galaxy clusters: A1656, A1367, A426, and A3627. This study is the first to test such a connection from an X-ray standpoint. Our analysis reveals no signs of enhanced X-ray AGN activity in our sample, with most RPS galaxies (~90%) showing X-ray luminosities below 1041 erg s−1 in their central point sources. Moreover, there is no noticeable difference in X-ray AGN activity among RPS galaxies compared to a control sample of non-RPS galaxies, as demonstrated by the similar X-ray luminosities observed in their central point sources. While the most luminous X-ray AGN in our sample is found in ESO 137-002, a galaxy undergoing RPS in A3627, there is no evidence for a widespread enhancement of X-ray AGN activity due to RPS. Given the limited sample size of our study, this could also indicate that either the X-ray AGN enhancement from RPS is at most weak or the timescale for the X-ray AGN enhancement is short. This emphasizes the need for further investigations with larger X-ray samples to better understand the impact of RPS on AGN activity in cluster galaxies.
Tides on Lava Worlds: Application to Close-in Exoplanets and the Early Earth–Moon System
Authors: Farhat Mohammad , Auclair-Desrotour Pierre , Boué Gwenaël , Lichtenberg Tim , Laskar Jacques 
Published: January 2025

Abstract
Understanding the physics of planetary magma oceans has been the subject of growing efforts, in light of the increasing abundance of solar system samples and extrasolar surveys. A rocky planet harboring such an ocean is likely to interact tidally with its host star, planetary companions, or satellites. To date, however, models of the tidal response and heat generation of magma oceans have been restricted to the framework of weakly viscous solids, ignoring the dynamical fluid behavior of the ocean beyond a critical melt fraction. Here we provide a handy analytical model that accommodates this phase transition, allowing for a physical estimation of the tidal response of lava worlds. We apply the model in two settings: the tidal history of the early Earth–Moon system in the aftermath of the giant impact, and the tidal interplay between short-period exoplanets and their host stars. For the former, we show that the fluid behavior of the Earth's molten surface drives efficient early lunar recession to ~25 Earth radii within 104–105 yr, in contrast with earlier predictions. For close-in exoplanets, we report on how their molten surfaces significantly change their spin–orbit dynamics, allowing them to evade spin–orbit resonances and accelerating their track toward tidal synchronization from a gigayear to megayear timescale. Moreover, we reevaluate the energy budgets of detected close-in exoplanets, highlighting how the surface thermodynamics of these planets are likely controlled by enhanced, fluid-driven tidal heating, rather than vigorous insolation, and how this regime change substantially alters predictions for their surface temperatures.
Finding Lensed Radio Sources with the Very Large Array Sky Survey
Authors: Martinez Michael N. , Gordon Yjan A. , Bechtol Keith , Cartwright Gillian , Ferguson Peter S. , Gorsuch Miranda 
Published: January 2025

Abstract
Radio observations of strongly lensed objects are valuable as cosmological probes. Lensed radio sources have proven difficult to identify, in large part due to the limited depth and angular resolution of the previous generation of radio sky surveys, and, as such, only a few dozen lensed radio sources are known. In this work, we present the results of a pilot study, using the Very Large Array Sky Survey (VLASS) in combination with optical data to more efficiently identify lensed radio sources. We obtain high-resolution (0

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″

2) VLA follow-up observations for 11 targets that we identify using three different techniques: (i) a search for compact radio sources offset from galaxies with high lensing potential, (ii) VLASS detections of known lensed galaxies, and (iii) VLASS detections of known lensed quasars. Five of our targets show radio emission from the lensed images, including 100% of the lensed optical quasar systems. This work demonstrates the efficacy of combining deep- and high-resolution wide-area radio and optical survey data to efficiently find lensed radio sources, and we discuss the potential impact of such an approach using next-generation surveys with the Vera C. Rubin Observatory, Euclid, and Nancy Grace Roman Space Telescope.
Simulations of Eccentricity Growth in Compact Binary Accretion Disks with Magnetohydrodynamic Turbulence
Authors: Ohana Morgan , Jiang 姜 Yan-Fei 燕飞 , Blaes Omer , Oyang Bryance 
Published: January 2025

Abstract
We present the results of four magnetohydrodynamic simulations and one alpha-disk simulation of accretion disks in a compact binary system, neglecting vertical stratification and assuming a locally isothermal equation of state. We demonstrate that in the presence of a net vertical field, disks that extend out to the 3:1 mean-motion resonance grow eccentricity in full MHD in much the same way as in hydrodynamical disks. Hence, turbulence due to the magnetorotational instability (MRI) does not impede the tidally driven growth of eccentricity in any meaningful way. However, we find two important differences with alpha-disk theory. First, in MHD, eccentricity builds up in the inner disk with a series of episodes of radial disk-breaking into two misaligned eccentric disks, separated by a region of circular orbits. Standing eccentric waves are often present in the inner eccentric disk. Second, the successful spreading of an accretion disk with MRI turbulence out to the resonant radius is nontrivial—and much harder than spreading an alpha disk. This is due to the tendency to develop overdense rings in which tidal torques overwhelm MRI transport and truncate the disk too early. We believe that the inability to spread the disk sufficiently was the reason why our previous attempt to excite eccentricity via the 3:1 mean-motion resonance with MHD failed. Exactly how MHD disks successfully spread outward in compact binary systems is an important problem that has not yet been understood.
Physical Pathways for JWST-observed Supermassive Black Holes in the Early Universe
Authors: Jeon Junehyoung , Bromm Volker , Liu Boyuan , Finkelstein Steven L. 
Published: January 2025

Abstract
Observations with the James Webb Space Telescope (JWST) have revealed active galactic nuclei (AGN) powered by supermassive black holes (SMBHs) with estimated masses of 107–108
M
⊙ at redshifts z ∼ 7–9. Some reside in overmassive systems with higher AGN to stellar mass ratios than locally. Understanding how massive black holes could form so early in cosmic history and affect their environment to establish the observed relations today are some of the major open questions in astrophysics and cosmology. One model to create these massive objects is through direct collapse black holes (DCBHs) that provide massive seeds (∼105–106
M
⊙), able to reach high masses in the limited time available. We use the cosmological simulation code GIZMO to study the formation and growth of DCBH seeds in the early Universe. To grow the DCBHs, we implement a gas swallowing model set to match the Eddington accretion rate as long as the nearby gaseous environment, affected by stellar and accretion disk feedback, provides sufficient fuel. We find that to create massive AGN in overmassive systems at high redshifts, massive seeds accreting more efficiently than the fiducial Bondi–Hoyle model are needed. We assess whether the conditions for such enhanced accretion rates are realistic by considering limits on plausible transport mechanisms. We also examine various DCBH growth histories and find that mass growth is more sustained in overdense cosmological environments, where high gas densities are achieved locally. We discuss the exciting prospect to directly probe the assembly history of the first SMBHs with upcoming, ultradeep JWST surveys.
Deep Searches for Radio Pulsations and Bursts from Four Magnetar and a Magnetar-like Pulsar with FAST
Authors: Bai Juntao , Wang Na , Dai Shi , Wang Shuangqiang , Yuan Jianping , Yan Wenming , Shang Lunhua , Xu Xin , Dang Shijun , Zhang Zhen 
Published: January 2025

Abstract
We report on radio observations of four magnetars SGR 0501+4516, Swift 1834.9–0846, 1E 1841–045, SGR 1900+14, and a magnetar-like pulsar PSR J1846–0258 with the Five-hundred-meter Aperture Spherical radio Telescope at 1250 MHz. Notably, PSR J1846–0258 was observed 1 month after its 2020 X-ray outburst. The data from these observations were searched for periodic emissions and single pulses. No radio emission was detected for any of our targets. After accounting for the effect of red noise, the nondetections yield stringent upper limits on the radio flux density, with S
1250 ≤ 16.9 μJy for the four magnetars and the magnetar-like pulsar, along with constraints on single-pulse flux densities. Our deep radio observations suggest that these magnetars and the magnetar-like pulsar are indeed radio-quiet sources or unfavorably beamed. The resulting flux upper limits, along with previous findings, are discussed, highlighting the significance of further radio observations of radio-quiet magnetars and the high-B magnetar-like pulsar.
Investigating the Compositional Heterogeneity of Pure, Crystalline Plagioclase Exposures within the Moon’s Anorthositic Crust Using Moon Mineralogy Mapper and Diviner Data
Authors: Martinot Mélissa , Hanna Kerri L. Donaldson , Greenhagen Benjamin T. , Santori Luis , Peplowski Patrick N. , Cahill Joshua T. S. 
Published: January 2025

Abstract
Questions about the formation of the primary anorthositic crust of the Moon remain unanswered. Spectroscopic surveys of the lunar crust have evidenced the presence of pure, crystalline plagioclase exposures (PCPEs) across the surface, which are assumed to be remnants of the Moon's ancient anorthositic crust. Results from our work show that the plagioclase composition within PCPEs in all geochemical terranes is relatively uniform and consistent with highly calcic anorthite found in immature and mature Apollo highlands regolith samples. Observed variations in our spectroscopic data sets are likely related to maturity, not plagioclase composition, supporting a single crust-forming event rather than serial magmatism. To constrain the plagioclase composition within the primary anorthositic crust, we use remote sensing data from two instruments on board different lunar orbiters, Moon Mineralogy Mapper (M3) and Diviner Lunar Radiometer (Diviner). When working with data sets acquired by different instruments, coregistration is key if one wants to extract values from those instruments at the same point on the lunar surface. Due to the suboptimal selenolocation of the M3 observations, misalignments exist between the M3 data and Diviner data sets. Here we present a methodology for extracting both data sets from a single locality while mitigating offsets, and provide results about the composition of the primary anorthositic crust. M3 was used to identify regions of interest within previously reported PCPEs at a selection of craters, and Diviner Christiansen feature data was utilized to constrain these locations’ plagioclase composition by comparing them against laboratory measurements of Apollo 16 highland soil samples.
An Automated Occultation Network for Gravitational Mapping of the Trans-Neptunian Solar System
Authors: Gomes Daniel C. H. , Bernstein Gary M. 
Published: January 2025

Abstract
We explore the potential of an array of

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small fixed telescopes, aligned along a meridian and automated to measure millions of occultations of Gaia stars by minor planets, to constrain gravitational signatures from a “Planet X” mass in the outer solar system. The accuracy of center-of-mass tracking of occulters is limited by photon noise, uncertainties in asteroid shapes, and Gaia’s astrometry of the occulted stars. Using both parametric calculations and survey simulations, we assess the total information obtainable from occultation measurements of main-belt asteroids (MBAs), Jovian Trojans, and trans-Neptunian objects (TNOs). We find that MBAs are the optimal target population due to their higher occultation rates and abundance of objects above Legacy Survey of Space and Time detection thresholds. A 10 yr survey of occultations by MBAs and Trojans using an array of 200 40 cm telescopes at 5 km separation would achieve 5σ sensitivity to the gravitational tidal field of a 5M
⊕ Planet X at 800 au for >90% of potential sky locations. This configuration corresponds to an initial cost of ≈$15 million. While the survey's sensitivity to tidal forces improves rapidly with increasing number of telescopes, sensitivity to a Planet X becomes limited by degeneracy with the uncertain masses of large moonless TNOs. The 200-telescope survey would additionally detect ≈1800 TNO occultations, providing detailed shape, size, and albedo information. It would also measure the Yarkovsky effect on many individual MBAs, measure masses of many asteroids involved in mutual gravitational deflections, and enable better searches for primordial black holes and departures from general relativity.