bluuebunny/crossref_metadata_2025_split huggingface dataset:
Representasi Keindahan dan Keheningan dalam Wajah Iklan Pariwisata Indonesia di Era Pandemi Covid-19: Analisis Retorika Visual
Authors: Hartanto Arief 
Published: April 2023

AbstrakDampak dari pandemi covid-19 pada sektor pariwisata telah terjadi krisis multi dimensi baik secara materiil dan non materiil. Keberadaan iklan bisa menjadi media komunikasi visual untuk merespon kondisi yang terjadi. Tujuan penelitian pada artikel ini untuk menggali makna dan pesan dari iklan pariwisata Indonesia, serta untuk mengetahui respon audien terhadap iklan tersebut yang ada di media Youtube. Penelitian ini menggunakan metode kualitatif. Pengambilan data melalui observasi visual, dokumentasi dan menggunakan aplikasi daring netlytic untuk mengambil data respon audien yang terdapat di iklan tersebut. Analisis menggunakan teori perspektif retorika visual dari Foss, dan menggunakan aplikasi daring netlytic untuk melakukan analisis teks dari respon audien. Hasil penelitiannya yaitu diketahui bahwa secara keseluruhan bentuk visual yang dihadirkan pada iklan ini berupa visual yang diam dan menghadirkan visual tentang keindahan objek pariwisata alam yang dimiliki Indonesia. Bentuk visual ini merepresentasikan keindahan dan keheningan yang kemudian merujuk pada peristiwa dan kondisi krisis yang sedang dihadapi. Audien juga mengapresiasi secara kualitas dari iklan pariwisata Indonesia ini baik secara teknis pengerjaan dan materi visual yang ada. Kata kunci: analisis teks, covid 19, iklan, pariwisata, retorika visual AbstractThe impact of the Covid-19 pandemic on the tourism sector has resulted in a multi-dimensional crisis, materially and non-materially either. The existence of advertising can be a medium of visual communication to respond to the occurring conditions. The research purpose of this article is to explore the meaning and the message of Indonesian tourism advertisements as well as find out the audience's response to these advertisements on YouTube media. This study uses a qualitative method. Data was collected through visual observation, documentation, and then using the netlytic online application to retrieve audience response to the data contained in the advertisement. The analysis uses Foss theory of visual rhetorical perspective and the netlytic online application to carry out text analysis of audience responses. The results of his research are shown that overall the visual form presented in this ad is the form of a still visual and presents the visual beauty of Indonesia's natural tourism objects. This visual form represents beauty and serenity which then refers to the events and conditions of the crisis being faced. The audience also appreciates the quality of this Indonesian tourism advertisement technically and in the existing visual materials either. Keywords: advertising, covid-19, texts analysis, tourism, visual rhetoric
Koherensi Lintas Moda sebagai Upaya untuk Meningkatkan Kualitas Buku Digital Dwibahasa Budhara (Borobudur Dalam Hamparan Cerita)
Authors: Mulatsih Sri , Nugroho Raden Arief , Suryaningtyas Valentina Widya , Soerjowardhana Aloysius , Muqoddas Ali , Udayanti Erika Devi 
Published: April 2023

Abstrak Sebagai upaya untuk meningkatkan kualitas informasi pariwisata Candi Borobudur dan Kawasan Cagar Budaya Borobodur, para peneliti membuat sebuah buku digital yang dinamai Budhara (Borobudur dalam Hamparan Cerita). Budhara dikembangkan dengan menggunakan metode Multimedia Development Life Cycle (MDLC). Buku digital ini dilengkapi dengan fitur-fitur, seperti navigasi, manipulasi, kontrol, pencarian, dan dialog. Karena adanya perbedaan perilaku berwisata antara wisatawan lokal dan mancanegara, tim peneliti membedakan visual atau gambar di halaman Budhara berbahasa Indonesia dan Inggris. Terlepas dari perbedaan tersebut, tim peneliti harus mempertahankan koherensi informasi visual dan teks tulisnya dari buku digital ini, karena hal ini dapat mempengaruhi indeks kepuasan wisatawan. Kata Kunci: Budhara, Buku Digital, Candi Borobudur, Koherensi Lintas Moda, Pariwisata AbstractAs an effort to improve the quality of tourism at Borobudur Temple and Borobudur Cultural Heritage Area (Kawasan Cagar Budya Borobudur), the researchers designed a digital book entitled Budhara (Borobudur dalam Hamparan Cerita). Budhara was designed using Multimedia Development Life Cycle method (MDLC). This digital book is equipped with features, such as navigation, manipulation, control, search, and dialog. Due to dissimilar travel behavior between domestic and international tourists, the researchers differentiate the visualization or pictures in Budhara’s Indonesian and English pages. Apart from the difference, the researchers must employ cross-modal coherence of Budhara’s visual information and its written one, in view of the fact that it can impact the tourist satisfaction index. Keywords: Budhara, Digital Book, Borobudur Temple, Cross-modal Coherence, Tourism
The student response on the use of renewable energy graphical interface simulator in learning environment
Authors: Gopabala Krishnan Lavaniya , Albani Aliashim , Segar Yogesswary , Ridzuan Abdul Rahim , Ismail Mohd Khairi , Musa Mohd Azlan , Gunaseelan Khemaalatha , Subramaniam Tamil Selvan , Ibrahim Mohd Zamri 
Published: April 2023

IntroductionThe purpose of this study is to evaluate students’ responses regarding the usefulness of a graphical user interface (GUI) tool in the context of their respective learning environments. The Energy Computator GUI (EC-GUI) helps to simplify the STEM student’s learning processes. The EC-GUI serves as a simulator that can assist in computing formulas, designing graphs, acting as a unit converter, and automatically deriving parameters.MethodologyFurthermore, a survey, which included closed and open questions, was carried out on a selection of students majoring in STEM subjects at Universiti Malaysia Terengganu (UMT) who were enrolled in the Renewable Energy course. A total of 54 respondents participated in the survey and 90.8% of them expressed satisfaction with the EC-GUI provided. The research involved using two distinct kinds of analysis: a parametric analysis, the paired sample t-test, and a non-parametric analysis, the Wilcoxon signed-rank test.ResultsThe study findings indicated that the majority of the respondents felt that the difficulty level of the subjects did not change after using the EC-GUI. However, it helped to simplify the learning process for students in STEM fields. The p-value of the appropriate teaching aid tool was less than 0.05, indicating that the results were significant both before and after using the EC-GUI.ConclusionThe study suggests that a similar GUI tool could be implemented in Malaysia’s teaching and learning processes as it is easy to build and use.
Predictive model of diabetes mellitus in patients with idiopathic inflammatory myopathies
Authors: Nie Qiong , Qin Li , Yan Wei , Luo Qiang , Ying Tao , Wang Han , Wu Jing 
Published: April 2023

ObjectivesCardiovascular diseases are the common cause of death in patients with idiopathic inflammatory myopathies (IIMs). Diabetes mellitus was associated with higher cardiovascular mortality, but few studies focused on the risk of diabetes mellitus in IIMs patients. Our study is aimed at developing a predictive model of diabetes mellitus in IIMs patients.MethodsA total of 354 patients were included in this study, of whom 35 (9.9%) were diagnosed as new-onset diabetes mellitus. The predictive nomogram was drawn based on the features selected by least absolute shrinkage and selection operator (LASSO) regression, univariate logistic regression, multivariable logistic regression, and clinical relationship. The discriminative capacity of the nomogram was assessed by C-index, calibration plot, and clinical usefulness. The predictive model was verified by the bootstrapping validation.ResultsThe nomogram mainly included predictors such as age, gender, hypertension, uric acid, and serum creatinine. This predictive model demonstrated good discrimination and calibration in primary cohort (C-index=0.762, 95% CI: 0.677-0.847) and validation cohort (C-index=0.725). Decision curve analysis indicated that this predictive model was clinically useful.ConclusionsClinicians can assess the risk of diabetes mellitus in IIMs patients by using this prediction model, and preventive measures should be taken early for high-risk patients, ultimately reducing the adverse cardiovascular prognosis.
Hyperglycemia-induced oxidative stress and epigenetic regulation of ET-1 gene in endothelial cells
Authors: Binjawhar Dalal Nasser , Alhazmi Alaa T. , Bin Jawhar Wejdan Nasser , MohammedSaeed Walaa , Safi Sher Zaman 
Published: April 2023

Introduction: Hyperglycemia-induced endothelial dysfunction and the subsequent increase of oxidative stress could lead to aberrant regulation of various genes which are responsible for a range of functions. This study aims to find out how hyperglycemia affect oxidative stress and then the expression and methylation of endothelin 1 (ET-1) gene in in human umbilical vein endothelial cells (HUVEC).Methods: Cells were cultured in growth medium and exposed to low and high glucose concentrations to mimic normal and diabetic condition respectively. Computational analysis were performed using UCSC genome browser and eukaryotic promoter database (EPD). The expression of ET-1 gene was investigated by real time PCR. Cytotoxicity and oxidative stress were determined by MTT and DCFH-DA assays respectively. Promoter methylation was assessed by the bisulfite sequencing method.Results: DCFH-DA assay showed that hyperglycemia can significantly increase the regulation of reactive oxygen species synthesis. The relative expression of ET-1 gene was increased due to exposure to high glucose concentration. MTT assay revealed reduced viability of cells due to the glucose induced damage. Methylation analysis revealed hypomethylation of the promoter of ET-1 however the difference was not significant. Out of 175 CpGs at 25 CpG sites, only 36 CpGs were methylated (20.5% methylation) in cell treated with normal glucose. Upon exposure to high glucose only 30 CpGs were methylated in 175 CpGs at 25 CpG sites (17.1% methylation).Discussion: Our study concludes a significantly high expression of ET-1 gene in response to high glucose exposure in HUVECs. It also reports that hyperglycemic condition leads to elevated oxidative stress. No significant change was found in methylation when cells were treated with high and low glucose concentrations.
LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling
Authors: Afsahi Arya , Silvestri Christopher M. , Moore Allyson E. , Graham Carly F. , Bacchiochi Kaylyn , St-Jean Martine , Baker Christopher L. , Korneluk Robert G. , Beug Shawn T. , LaCasse Eric C. , Bramson Jonathan L. 
Published: April 2023

BackgroundThe genesis of SMAC mimetic drugs is founded on the observation that many cancers amplify IAP proteins to facilitate their survival, and therefore removal of these pathways would re-sensitize the cells towards apoptosis. It has become increasingly clear that SMAC mimetics also interface with the immune system in a modulatory manner. Suppression of IAP function by SMAC mimetics activates the non-canonical NF-κB pathway which can augment T cell function, opening the possibility of using SMAC mimetics to enhance immunotherapeutics.MethodsWe have investigated the SMAC mimetic LCL161, which promotes degradation of cIAP-1 and cIAP-2, as an agent for delivering transient costimulation to engineered BMCA-specific human TAC T cells. In doing so we also sought to understand the cellular and molecular effects of LCL161 on T cell biology.ResultsLCL161 activated the non-canonical NF-κB pathway and enhanced antigen-driven TAC T cell proliferation and survival. Transcriptional profiling from TAC T cells treated with LCL161 revealed differential expression of costimulatory and apoptosis-related proteins, namely CD30 and FAIM3. We hypothesized that regulation of these genes by LCL161 may influence the drug’s effects on T cells. We reversed the differential expression through genetic engineering and observed impaired costimulation by LCL161, particularly when CD30 was deleted. While LCL161 can provide a costimulatory signal to TAC T cells following exposure to isolated antigen, we did not observe a similar pattern when TAC T cells were stimulated with myeloma cells expressing the target antigen. We questioned whether FasL expression by myeloma cells may antagonize the costimulatory effects of LCL161. Fas-KO TAC T cells displayed superior expansion following antigen stimulation in the presence of LCL161, suggesting a role for Fas-related T cell death in limiting the magnitude of the T cell response to antigen in the presence of LCL161.ConclusionsOur results demonstrate that LCL161 provides costimulation to TAC T cells exposed to antigen alone, however LCL161 did not enhance TAC T cell anti-tumor function when challenged with myeloma cells and may be limited due to sensitization of T cells towards Fas-mediated apoptosis.
High levels of exfoliated fragments following glycocalyx destruction in hemorrhagic fever with the renal syndrome are associated with mortality risk
Authors: Du Hong , Hu Haifeng , Li Jing , Wang Xiaoyan , Jiang Hong , Lian Jianqi , Zhang Ying , Wang Pingzhong 
Published: April 2023

BackgroundThe glycocalyx is a gel-like structure that covers the luminal side of vascular endothelial cells. It plays an important role in maintaining the integrity of the vascular endothelial barrier structure. However, the presence or absence of glycocalyx destruction in hemorrhagic fever with renal syndrome (HFRS) and its specific mechanism and role is still unclear.MethodsIn this study, we detected the levels of exfoliated glycocalyx fragments, namely, heparan sulfate (HS), hyaluronic acid (HA), and chondroitin sulfate (CS), in HFRS patients and investigated their clinical application value on the evaluation of disease severity and prognosis prediction.ResultsThe expression of exfoliated glycocalyx fragments in plasma was significantly increased during the acute stage of HFRS. The levels of HS, HA, and CS in HFRS patients during the acute stage were significantly higher than in healthy controls and convalescent stages of the same type. HS and CS during the acute stage gradually increased with the aggravation of HFRS, and both fragments showed a significant association with disease severity. In addition, exfoliated glycocalyx fragments (especially HS and CS) showed a significant correlation with conventional laboratory parameters and hospitalization days. High levels of HS and CS during the acute phase were significantly associated with patient mortality and demonstrated an obvious predictive value for the mortality risk of HFRS.ConclusionGlycocalyx destruction and shedding may be closely associated with endothelial hyperpermeability and microvascular leakage in HFRS. The dynamic detection of the exfoliated glycocalyx fragments may be beneficial for the evaluation of disease severity and prognosis prediction in HFRS.
Accuracy of non-invasive cuffless blood pressure in the intensive care unit: Promises and challenges
Authors: Heimark Sondre , Bøtker-Rasmussen Kasper Gade , Stepanov Alexey , Haga Øyvind Gløersen , Gonzalez Victor , Seeberg Trine M. , Fadl Elmula Fadl Elmula M. , Waldum-Grevbo Bård 
Published: April 2023

ObjectiveContinuous non-invasive cuffless blood pressure (BP) monitoring may reduce adverse outcomes in hospitalized patients if accuracy is approved. We aimed to investigate accuracy of two different BP prediction models in critically ill intensive care unit (ICU) patients, using a prototype cuffless BP device based on electrocardiogram and photoplethysmography signals. We compared a pulse arrival time (PAT)-based BP model (generalized PAT-based model) derived from a general population cohort to more complex and individualized models (complex individualized models) utilizing other features of the BP sensor signals.MethodsPatients admitted to an ICU with indication of invasive BP monitoring were included. The first half of each patient’s data was used to train a subject-specific machine learning model (complex individualized models). The second half was used to estimate BP and test accuracy of both the generalized PAT-based model and the complex individualized models. A total of 7,327 measurements of 15 s epochs were included in pairwise comparisons across 25 patients.ResultsThe generalized PAT-based model achieved a mean absolute error (SD of errors) of 7.6 (7.2) mmHg, 3.3 (3.1) mmHg and 4.6 (4.4) mmHg for systolic BP, diastolic BP and mean arterial pressure (MAP) respectively. Corresponding results for the complex individualized model were 6.5 (6.7) mmHg, 3.1 (3.0) mmHg and 4.0 (4.0) mmHg. Percentage of absolute errors within 10 mmHg for the generalized model were 77.6, 96.2, and 89.6% for systolic BP, diastolic BP and MAP, respectively. Corresponding results for the individualized model were 83.8, 96.2, and 94.2%. Accuracy was significantly improved when comparing the complex individualized models to the generalized PAT-based model in systolic BP and MAP, but not diastolic BP.ConclusionA generalized PAT-based model, developed from a different population was not able to accurately track BP changes in critically ill ICU patients. Individually fitted models utilizing other cuffless BP sensor signals significantly improved accuracy, indicating that cuffless BP can be measured non-invasively, but the challenge toward generalizable models remains for future research to resolve.
Case report: Outer lamellar macular hole and outer retinal detachment within myopic foveoschisis post-cataract surgery
Authors: Eng Yii Hern , Ong Kah Wei , Yong Meng Hsien , Wan Abdul Halim Wan Haslina , Bastion Mae-Lynn Catherine 
Published: April 2023

BackgroundThis study aimed to report a case of outer lamellar macular hole and outer retinal detachment within myopic foveoschisis (MF) post-cataract surgery.Case presentationAn elderly female patient with bilateral high myopia and pre-existing myopic foveoschisis underwent uncomplicated sequential cataract surgeries 2 weeks apart. She was able to achieve a satisfactory visual outcome for her left eye with stable myopic foveoschisis and visual acuity of 6/7.5, near vision N6. However, her right eye vision remained poor postoperatively, with a visual acuity of 6/60. Macular optical coherence tomography (OCT) revealed a new right eye outer lamellar macular hole (OLMH) and outer retinal detachment (ORD) within pre-existing myopic foveoschisis. Her vision remained poor after 3 weeks of conservative management, and she was offered vitreoretinal surgical intervention with pars plana vitrectomy, internal limiting membrane peeling, and gas tamponade. However, she refused surgical intervention, and her right vision remained stable at 6/60 over 3 months of follow-up.ConclusionOuter lamellar macular hole and outer retinal detachment within myopic foveoschisis can occur soon after cataract surgery, which may be related to the progression of associated vitreomacular traction, and have a poor visual outcome if left untreated. Patients with high myopia should be informed of these complications as part of pre-operative counseling.
Comparison of ultrasound phacoemulsification and FemtoMatrix® PhotoEmulsification® cataract surgery
Authors: de Saint Jean Amélie , Dufournel Damien , Stodulka Pavel , Romano Fabrice , Bernard Aurélien 
Published: April 2023

ObjectiveTo introduce a novel technology currently under final development before regulatory approvals for the furtherment of cataract surgery, using the FemtoMatrix® laser system, and to demonstrate its safety and efficacy as compared to standard ultrasound phacoemulsification.MethodsThirty-three patients with bilateral cataracts were operated on with one eye undergoing PhotoEmulsification® treatment on the FemtoMatrix® device and the contralateral eye receiving the control procedure, i.e., standard ultrasound phacoemulsification treatment. The number of “zero-phaco” procedures (denoting that I/A alone was sufficient to aspirate the lens fragments and that no ultrasound energy was needed) was recorded and Effective Phaco Time (EPT) values were compared. The patient follow-up was 3 months.ResultsThirty-three eyes from a population with a mean cataract grade of 2.6 were treated on the FemtoMatrix®, of which 29 were “zero-phaco” (88%). All patients were operated on by a single surgeon who was a relative novice to the technology (63 patients treated prior to this study). Conversely, of the 33 fellow eyes who underwent standard ultrasound phacoemulsification, none were zero-phaco (0%) - all required varying degrees of ultrasound energy to make lens aspiration possible. The mean EPT was significantly lower in the PhotoEmulsification® laser group (0.2 ± 0.8 s) than in the phaco group (1.3 ± 1.2 s) (p &lt; 0.0001). The safety profiles of the two procedures were comparable, with no device-related adverse events noted.ConclusionFemtoMatrix® is a promising femtosecond laser platform that, when compared to phacoemulsification, significantly decreases or eliminates EPT altogether. The system is used to perform PhotoEmulsification®, making zero-phaco cataract procedures feasible including in high-grade cataracts (&gt;3). It enables personalized treatment by automatically measuring and adapting the laser energy required to obtain the most efficient cutting of the crystalline lens. This new technology appears to be safe and effective in cataract surgery.
Inflammatory bowel disease is causally related to irritable bowel syndrome: a bidirectional two-sample Mendelian randomization study
Authors: Ke Haoran , Li Zitong , Lin Qianyun , Shen Zefeng , Chen Ye , Chen Jinjun 
Published: April 2023

IntroductionInflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are lifelong digestive diseases that severely impact patients’ quality of life. The existence of a causal association between IBS and IBD remains unclear. This study aimed to determine the direction of causality between IBD and IBS by quantifying their genome-wide genetic associations and performing bidirectional two-sample Mendelian randomization (MR) analyses.MethodsGenome-wide association studies (GWAS) among a predominantly European patient cohort identified independent genetic variants associated with IBS and IBD. Two separate databases (a large GWAS meta-analysis and the FinnGen cohort) for both IBS and IBD were consulted to retrieve statistics on instrument-outcome associations. MR analyses included inverse-variance-weighted, weighted-median, MR-Egger regression, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) methods, and sensitivity analyses were performed. The MR analyses were carried out for each outcome data, followed by a fixed-effect meta-analysis.ResultsGenetically predicted IBD was associated with an increased risk of IBS. Odds ratios (95% confidence intervals) for samples of 211,551 (17,302 individuals with IBD), 192,789 (7,476 Crohn’s disease cases), and 201,143 (10,293 ulcerative colitis cases) individuals were 1.20 (1.00, 1.04), 1.02 (1.01, 1.03), and 1.01 (0.99, 1.03), respectively. After outlier correction using MR-PRESSO, the odds ratio for ulcerative colitis was 1.03 (1.02, 1.05) (p = 0.001). However, an association between genetically influenced IBS and IBD was not identified.DiscussionThis study confirms that IBD is causally related to IBS, which may interfere with the diagnosis and treatment of both diseases.