bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Pilot Study Comparing a Community of Practice Group Therapy Program with and without Concurrent Ketamine-assisted Therapy
Authors: Tsang V. W. L. , Moyer R. , Kryskow P. , Walsh Z. , Dames S. 
Published: August 2023

IntroductionHealthcare practitioners (HCPs) are facing a mental health crisis. Group therapies have long been used to treat symptoms associated with PTSD, anxiety and/or depression, however no studies have investigated the role of implementing group therapy with and without ketamine-assisted therapies (KaT).ObjectivesThe current study investigated the effects of the Roots to Thrive (RTT) group therapy intervention both with and without adjunctive KaT.MethodsIn the present study we conduct a secondary analysis of data derived from the 12-week group psychotherapy program to that of the same program with adjunct KaT. Participants were administered a series of validated psychiatric assessment tools before and after the 12-weeks. Inclusion criteria included a diagnosis of treatment resistant mental health condition (depression, PTSD and/or generalized anxiety disorder) and a score of 15 or greater on the PTSD Checklist for DSM-5 (PCL-5). To assess the effects of time x group interaction and calculate differences between the RTT only and RTT-KaT subgroups, a repeated measures ANOVA was conducted. Effect sizes were calculated through partial eta-squared.ResultsForty-nine HCPs with treatment-resistant PTSD, anxiety and/or depression were treated with the RTT group therapy model to target their symptoms. A total of 49 individuals (34 female, 10 male, 3 other) with a median age of 47 years old (SD 14.19) participated in the study. There were no statistically significant differences between RTT only (n=14) and RTT KaT (n=35) subgroups across gender [X2 (1, N=44) = 2.84, ns] or age [F (1, 36) = .257, p = .615]. From pre- to post-treatment, all patients showed significant reductions in scores of PTSD (from 39.3 to 20.99), depression (from 15.5 to 7.7) and anxiety (from 15.5 to 6.2). Two-way repeated measures ANOVA did not reveal any significant between-group differences between the RTT and RTT-KaT subgroups.ConclusionsThis observational study provides preliminary support for the potential of the RTT community of care model of group therapy and adds to a small but growing body of knowledge on the integration of group therapy and the broad category of psychedelic psychotherapies. Given the rapid proliferation and expansion of KaT clinics throughout North America, the finding that KaT did not appear to impact changes related to the RTT intervention suggests the need for further research to better explain the potential impacts of relational transference between the two groups, and the distinct contributions of ketamine administration in a group therapy context.Disclosure of InterestNone Declared
Childhood trauma and anger in adults with and without depressive and anxiety disorders
Authors: De Bles N. , Putz L. E. , Rius Ottenheim N. , van Hemert A. M. , Elzinga B. M. , Penninx B. W. , Giltay E. J. 
Published: August 2023

IntroductionChildhood trauma (CT) is associated with severe sequelae, including personality disorders and stress-related mental health disorders that can perpetuate long into adulthood.ObjectivesWe aimed to investigate (1) whether childhood trauma is associated with anger in adulthood, and, if so, (2) to explore which types of childhood trauma predominate in the prediction of anger, and (3) to explore whether the association is independent of psychopathology in a cohort that included participants without lifetime psychiatric disorders, with current or remitted depressive and anxiety disorders, or comorbid depressive and anxiety disorders.MethodsIn the Netherlands Study of Depression and Anxiety (NESDA), childhood trauma was assessed with a semi-structured Childhood Trauma Interview (CTI) at baseline, and analyzed in relation to anger as measured at 4-year follow-up with the Spielberger Trait Anger Subscale (STAS), the Anger Attacks Questionnaire, and cluster B personality traits (i.e., borderline, antisocial) of the Personality Disorder Questionnaire 4 (PDQ-4), using analysis of covariance (ANCOVA) and multivariable logistic regression analyses. Post-hoc analyses comprised cross-sectional regression analyses, using the Childhood Trauma Questionnaire – Short Form (CTQ-SF) obtained at 4-year follow-up.ResultsParticipants (n = 2,276) were on average 42.1 years (SD = 13.1), and 66.3% were female. Childhood trauma showed a dose-response association with all anger constructs. Zooming in, all types of childhood trauma except for sexual abuse were associated with higher levels of trait anger, and a higher prevalence of anger attacks and antisocial personality traits in adulthood, independently of depression and anxiety. Additionally, all types of childhood trauma were significantly associated with borderline personality traits. Cross-sectionally, the effect sizes were larger compared to the analyses with the childhood trauma measured four years prior to the anger measures.ConclusionsChildhood trauma is linked with anger in adulthood, most strongly for trait anger and borderline personality traits. It is of clinical importance to explore childhood traumatic experience and start trauma-focused interventions when appropriate.Disclosure of InterestNone Declared
Mental Health and Life Events among United States adolescents with Substance Use Disorders
Authors: Sultan R. , Zhang A. , Levin F. 
Published: August 2023

IntroductionSubstance use during adolescence is linked to adverse biopsychosocial events, including poor mental health, cognitive deficits, low academic performance, and delinquency (Deas & Brown J Clin Psych 2006; 67 18; Armstrong & Costello JCCP 2002; 70 1224; Cox et al. JSH 2007; 77 109-115; Chassin JJSU 2008; 165-183). Identifying risks for these events is critical, given they are associated with adverse outcomes in adulthood.Post-pandemic, rates of adolescent depression and anxiety have more than doubled (Racine et al. JAMA Ped 2021; 175 1142-1150). Adolescents often use substances, most commonly alcohol and cannabis, to manage mental health (Colder et al. JCCP 2019; 87 629).Cannabis is increasingly viewed by adolescents as safe, while alcohol is viewed negatively (SAMHSA 2021). Non-disordered alcohol use (ND-AU), alcohol use below diagnostic criteria level, has adverse developmental impacts for adolescents, including increased risk-taking behavior and heavy substance use in adulthood (Marshall Alcohol Alcohol. 2014; 49 160-164).With growing normalization of cannabis use, important questions still remain whether non-disordered cannabis use (ND-CU) among adolescents is linked to adverse life events.ObjectivesUsing data from the 2018-2020 National Survey on Drug Use and Health (NSDUH), an annual US representative survey on substance use and mental health, we compared associations among common adolescent substance use and adverse life events.MethodsResponses from adolescents aged 12-17 (N=32,407) from the 2018-2020 NSDUH were analyzed. Logistic regression was used to evaluate associations between substance use disorder (SUD) diagnoses and adverse adolescent life events. Adjusted odds ratios (aOR) were obtained while controlling for age, sex, and race/ethnicity. Analyses included sampling weights to account for the US population. Adolescents in ND-CU and ND-AU groups were defined by either past-month or past-year use without their respective SUD diagnosis.ResultsApproximately 5% of adolescents had any SUD, and 1.3% had more than one SUD (Table 1). All SUD variables, including cannabis use disorder (CUD) and alcohol use disorder (AUD), were significant for all adverse adolescent life events (Table 2). Adolescents with a SUD were nearly 3 times more likely to have major depression in the past year, 2.5 times more likely to have a C+ or below grade average, and 10 times more likely to be arrested, than controls. These risks increased with more than one SUD (Table 2). Adverse events were similar between ND-CU and ND-AU. (Figure 1).Image:Image 2:Image 3:ConclusionsGiven the biopsychosocial risks to ND-CU and ND-AU in adolescents, there may be reason to reevaluate whether the DSM adequately captures the population of youth affected by their cannabis and alcohol use. Clinicians can use these nationally representative data to stratify risks and direct to appropriate treatment.Disclosure of InterestNone Declared
Mitochondrial disorders and ASD. Mechanisms of mitochondrial dysfunction in ASD
Authors: Sidenkova A. 
Published: August 2023

IntroductionASD is a multifactorial disease. They arise from the interaction of various genetic and environmental factors. These factors affect specific neuronal circuits, oxidative stress, neuroinflammation, mitochondrial dysfunction. This disrupts the development of the nervous system, the formation of synapses, the connection between brain regions, and the size of the brain. Almost 80% of patients with ASD suffer from mitochondrial dysfunction. Therefore, mitochondrial dysfunction plays a crucial role in the pathogenesis of ASD.ObjectivesDeficiency of adenosine-triphosphate (ATP) and abnormal levels of Reactive oxygen species (ROS) cause mitochondrial dysfunction in ASD. This leads to metabolic disorders, disorders of synaptic plasticity and disorders of the immune responseMethodsThe negative association between pathogenic mtDNA mutations and IQ is specific for children with ASD / MD. The overall prevalence of these abnormalities is 1.2 times higher in ASD / MD. ASD, researchers reaffirm that autistic probands carry the burden of mutations in mtDNA, especially mutations that are prone to deleterious effects on OXPHOS. According to a number of researchers, all children with ASD should be screened for MD, given: the high prevalence of abnormal markers of mitochondrial function in ASD compared with the control group; relatively high prevalence of MD in ASD; some children with ASD who have MD may be phenotypically indistinguishable from typical children with ASD; the potential clinical significance of MD in children with ASD.ResultsAccording to a number of researchers, all children with ASD should be screened for MD, given: the high prevalence of abnormal markers of mitochondrial function in ASD compared with the control group; relatively high prevalence of MD in ASD; some children with ASD who have MD may be phenotypically indistinguishable from typical children with ASD; the potential clinical significance of MD in children with ASD.ConclusionsThe pathophysiological mechanisms of ASD are multifactorial. They are largely unclear. But the mitochondrial hypothesis of the pathogenesis of ASD is being clarified. Mitochondrial dysfunction has been identified as a hallmark of diseased neurons in ASD patients, suggesting a critical role for mitochondrial dysfunction in the pathogenesis of ASD and allowing the development of ASD correction by normalizing mitochondrial functions.Disclosure of InterestNone Declared
Accelerated repetitive transcranial magnetic stimulation (ATMS) vs standard repetitive transcranial magnetic stimulation (RTMS) in the treatment of major depressive episodes. preliminary data of a randomized, single-blind, controlled trial
Authors: Prato M. , Ragone N. , Passani C. , Cardaci V. , Seghi F. , Barbini B. , Colombo C. 
Published: August 2023

IntroductionMajor Depressive Disorder is a frequent and disabling condition. More than 20% of patients do not respond to pharmacotherapy alone, so there is the need to find alternative strategies in order to potentiate the drugs. Therapeutic alternatives include repetitive Transcranial Magnetic Stimulation (rTMS), which has shown an antidepressant effect in the last decades.ObjectivesComparison of the efficacy of accelerated repetitive Transcranial Magnetic Stimulation (aTMS) treatment (4 sessions/day for 5 days) with the standard rTMS protocol treatment (1 session/day for 4 weeks), using the FDA-approved parameters.Methods33 patients affected by Major Depressive Episodes treated with either Fluvoxamine or Venlafaxine were enrolled. Patients were randomly assigned to the two protocol groups: standard rTMS protocol (15 patients) and aTMS protocol (18 patients). In the standard protocol, patients received 1 rTMS session/day for 4 weeks, while in the aTMS protocol they received 4 rTMS sessions/day for 5 days. Symptomatological improvement was evaluated through MADRS, BDI-II and SSI rating scales administered on day: 0, 1, 2, 3, 4, 5, 14, 21, 28, 56. The study is single-blind, since the clinical rater was unaware of the treatment protocol group. Response and remission rates were calculated, defined respectively as a reduction ≥50% in the MADRS score and a MADRS score <10.ResultsThe analysis was carried out on 32 patients (18 in the aTMS group and 14 in the rTMS group). ANOVA for repeated measures shows a statistically significant difference in the MADRS scores on day 5 (p=0.001) and on day 56 (p=0.037). Regarding the BDI-II evaluation, the differences were not fully statistically significant on day 5 and not significant on day 56. No statistically significant differences between the two protocols were observed in the SSI assessment. The aTMS and rTMS response rates were respectively 84.6% vs 45.5% on day 28 (p=0.043) and 92.3% vs 45.5% on day 56 (p=0.012). The aTMS and rTMS group remission rates were respectively 76.9% vs 18.2% on day 28 (p=0.004) and 69.2% vs 36.4% on day 56 (p=0.107). Concerning side effects, no statistically significant differences were observed between the two groups.ConclusionsTreatment with aTMS seems faster and more effective than treatment with standard rTMS in improving the clinical condition in patients with Major Depressive Episodes, allowing to treat patients in just 5 days instead of 4-6 weeks, without impacting on side effects and tolerability.Disclosure of InterestNone Declared
The effect of COVID-19 pandemic on depression and suicidal ideation in Korean community dwelling elderly
Authors: Kim K. , Yoon B.-H. , Jung H. , Yun H. 
Published: August 2023

IntroductionThe impacts of the coronavirus disease of 2019 (COVID-19) pandemic on mental health have been relatively severe.ObjectivesThis study examined the influence of the COVID-19 especially on depression and suicidal ideation in community-dwelling elderly in Korea.MethodsData were employed from a survey on elderly mental health in Jeollanam-do (southwest province in Korea). A total of 2,423 elderlies were recruited from 22 counties in Jeollanam-do between April and October 2021. We used self-reported questionnaires, including sociodemographic factors, COVID-19 related stress, suicidal ideation, Geriatric Depression Scale-Short Form Korean Version (GDS-SF). Logistic regression was performed to examine the factors on depression and suicidal ideationResultsOf the 2423 subjects, 622 (25.7%) reported depressive symptoms and 518 (21.4%) reported suicidal ideation. The multivariate logistic regression analysis revealed that living alone, poor perceived health status, the worry of COVID-19 infection and restriction of daily activity due to COVID-19 pandemic were significantly associated with depression. Male sex, poor perceived health status, disability in house chores and depressive symptom are risk factors for suicidal ideation.Image:Image 2:Image 3:ConclusionsThese findings showed that increased risk factor for depression and suicidal ideation in community dwelling elderly during COVID-19 pandemic. We confirmed that feelings of isolation and negative perception of health were risk factors on depression in community dwelling elderly in the context of the COVID –19 pandemic. Also male, poor self-perceived health status, difficulty of independent living and worry and depression are increased the risk of suicidal ideation among the elderly.Disclosure of InterestNone Declared
Addictive behaviors among healthcare workers: A bicentric Tunisian Study
Authors: Omrane A. , Dabbebi H. , Mlouki I. , Khalfallah T. , EL Mhamdi S. 
Published: August 2023

IntroductionAddiction is a disease that comes with a range of consequences. Its physical, mental, personal, social and financial repercussions could not be neglected. Yet, this issue is still stigmatized. It is a public health problem that may affect people from different backgrounds including healthcare professionals.ObjectivesTo investigate the risk factors for a substance addiction: cigarette addiction and behavioral addiction: internet addiction among health care professionals.MethodsA cross-sectional bi-centric study was conducted among healthcare workers from two public hospitals in the center-east of Tunisia. A questionnaire was distributed to those who gave their oral consent to take part in the study. It included items related to participants’ socio-demographic characteristics, medical history, self-esteem and mood assessment. It combined questions from the Rosemberg self-esteem scale (RSES) and the Beck Depression Inventory alongside with validated tests: Adverse Childhood Experiences (ACE-IQ), the Fagerstrom Test for Cigarette Dependence and the Internet Addiction Test (IAT).ResultsAmong respondents, 16.1% were smokers. Risk factors for smoking were: being a male (OR=9.62), being in contact with patients (OR=4.75), a job tenure exceeding ten years (OR=3.11), having regular alcohol consumption (OR=7.27), unprotected sex (OR=9.24), depression (OR=3.87) or having suffered from sexual abuse during childhood (3.07). Nevertheless, practicing sport regularly (OR=0.32) and anxiety (OR=0.23) were identified protective factors. A high level of cigarette addiction was observed with 34.3% of cigarette smokers. Predictors of high cigarette dependence were: job tenure over ten years (OR=20.69), regular alcohol consumption (OR=6.11) and unprotected sex (OR=7.14). Among healthcare workers, 70.8% reported a normal internet use. Internet addiction was specially seen with those who were not engaged (OR=2,92) and those who worried about being unsuccessful (OR=1.91). Good self-esteem and being older were protective factors with OR=0.49 and OR=0.38 successively. Depression did not contribute to the development of internet addiction, on the opposite it protected against it (OR=0.36).ConclusionsCigarette and internet addiction are threatening health problems that need more effort to screen and address. This public health issue has never stopped growing with the emergence of new types of illicit drugs and behaviours. Finally, this study draws attention to the importance of assessing the prevalence of different categories of addiction in Tunisia and highlights the necessity of updating policies used to address these addictions in a timely and appropriate way.Disclosure of InterestNone Declared
Analysis of the relationship between personality traits and Internet addiction
Authors: Cybulska A. M. , Rachubińska K. , Schneider-Matyka D. , Grochans S. , Grochans E. 
Published: August 2023

Introduction
Behavioral addictions are a growing problem in the society. Digital technologies are
used by people of different ages, and their number is increasing every year. The precise
reasons for the development of addictions remain unknown. In the case of behavioral
addictions, especially Internet addiction, the significance of personality traits and
behaviors predisposing an individual to addiction, such as depressiveness, anxiety, hostile
attitude, aggression, impulsiveness, psychotic behaviors, shyness and self-esteem disorders,
are emphasized. Personality predispositions play an essential role in Internet
addiction.

Objectives
The aim of this study was a general assessment of the level of Internet addiction with
regard to personality traits according to the Big Five model by Costa and McCrae among women
from the West Pomeranian Voivodeship.

Methods
The study involved 556 women, whose average age was 34 years and who met the inclusion
criteria: female sex, age of 18 years or above, place of residence in the West Pomeranian
Voivodship, an informed consent for participation in the study, and completion of the set of
questionnaires. The study was conducted using a diagnostic poll method with a questionnaire
technique. To carry out the analysis both author’s own and standardized tools were used: the
author’s questionnaire covering socio-demographic data, the NEO-Five Factor Inventory which
assesses the levels of personality traits, and the Internet Addiction Test used to measure
behaviors and characteristics related to compulsive use of the Internet.

Results
Most (70.9%) of the women were average users of the Internet, 25% of respondents were
at risk of addiction, and the least numerous group of women (4.1%) was addicted to the
Internet. Conscientiousness negatively correlated with Internet addiction (r = -0.22; p <
0.001; R2 = 4.9%). Openness to experience was conducive to Internet addiction (r = 0.15; p
< 0.001; R2 = 11.1%). A positive link between neuroticism and Internet addictions was
established (r = 0.33; p < 0.001; R2 = 11.1%). No significant relationships between
Internet addiction and extraversion (r = 0.03; p = 0.45) as well as agreeableness (r = -0.07;
p = 0.10) were demonstrated.

Conclusions
The type of personality of the studied women implicated relationships to Internet
addiction. Neuroticism might be a personality trait that particularly predisposes to an
increased risk of Internet addiction. Openness to experience was conducive to Internet
Addiction. Low levels of conscientiousness more often become addicted to the
Internet.

Disclosure of Interest
None Declared
Prevalence of depression among Iraqi dentistry students during COVID-19 returning to onsite learning: A cross-sectional study
Authors: Alhashem G. , Abbas A. A. R. , Ali S. A. J. , Almhanna A. 
Published: August 2023

IntroductionThroughout the COVID-19 pandemic, students were vulnerable to mental health issues and dentistry students were no exception. All Iraqi universities were transitioning back to face-to-face learning in the last year. Acclimatization with all pandemic regulations that schools apply might increase the vulnerability to depression.ObjectivesThe current study aims to assess the levels of depression among Iraqi dentistry students after transitioning from online to onsite learning during the pandemic period.MethodsA cross-sectional study was conducted online after transitioning from online to the onsite learning method during the pandemic period. Sociodemographic data and Patient Health Questionnaire-8 (PHQ-8) were included in the questionnaire.ResultsA total of 307 respondents, 216 (70.4%) female and 91 (29.6%) male, 276 (90%) live with family, 20 (6.5%) live with friends and 11 (3.5%) live alone, 268 (87.3%) of student claimed that post-COVID-19 regulations face to face learning is more stressful while 39 (12.7%) answered no difference. 39 (12.7%) of dentistry student with normal level of depression, 199 (38.8%) have mild depression 101 (32.9%) moderate depression, 32 (10.4%) moderately severe, 16 (5.2%) severe. Depression level and students’ perception of teaching mode transition showed a significant association (p<0.05).However, there are no significant associations between gender, living conditions, or dentistry stages with depression levels (p>0.05).ConclusionsA high prevalence of depression symptoms among Iraqi dentistry students was found during onsite learning, along with all educational institutions’ pandemic rules and regulations. Psychological supporting preventive programs are needed to apply for supporting students’ mental health.Disclosure of InterestNone Declared