bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet-based and mobile-based cognitive behavioral therapy for chronic diseases: a systematic review and meta-analysis
Authors: Tao Tiffany Junchen , Lim Teck Kuan , Yeung Ernest Tsun Fung , Liu Huinan , Shris Phoenix Bibha , Ma Lawrence Ka Yin , Lee Tatia Mei Chun , Hou Wai Kai 
Published: April 2023

AbstractPositive adjustment to chronic diseases reduces psychiatric comorbidity and enhances quality of life. Very little is known about the benefit of internet-based and mobile-based Cognitive Behavioral Therapy (IM-CBT) on physical outcomes and its reciprocal interactions with psychiatric outcomes, the active therapeutic elements, and effect moderators among people with major chronic medical conditions. In this systematic review and meta-analysis (PROSPERO: CRD42022265738), CINAHL of Systematic Reviews, MEDLINE, PsycINFO, PubMed, Web of Science are systematically searched up to 1 June 2022, for randomized controlled trials (RCTs) comparing IM-CBT against non-CBT control condition(s) among people with chronic disease(s). Primary outcomes include improvements in psychiatric symptoms (depressive, anxiety, PTSD symptoms, general psychological distress) from baseline to post-intervention and follow-ups. Secondary outcomes include improvements in physical distress (physical symptoms, functional impairment, self-rated ill health, objective physiological dysfunction). Among 44 RCTs (5077 patients with seven different chronic diseases), IM-CBT improves depressive symptoms, anxiety symptoms, and general psychological distress at post-intervention and across follow-ups, and improves physical distress and functional impairment at post-intervention. Preliminary evidence suggests that behavioral modification and problem-solving could be necessary components to reduce psychiatric symptoms in IM-CBT, whereas cognitive restructuring, psychoeducation, and mindfulness elements relate to reduced physical distress. IM-CBT shows stronger benefits in chronic pain, cancer, arthritis, and cardiovascular disease, relative to other conditions. Changes in psychiatric symptoms and physical distress prospectively predict each other over time. IM-CBT is an effective intervention for comprehensive symptom management among people with chronic diseases.
OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems
Authors: Mendonca Tania , Lis-Slimak Katarzyna , Matheson Andrew B. , Smith Matthew G. , Anane-Adjei Akosua B. , Ashworth Jennifer C. , Cavanagh Robert , Paterson Lynn , Dalgarno Paul A. , Alexander Cameron , Tassieri Manlio , Merry Catherine L. R. , Wright Amanda J. 
Published: April 2023

AbstractBiomechanical cues from the extracellular matrix (ECM) are essential for directing many cellular processes, from normal development and repair, to disease progression. To better understand cell-matrix interactions, we have developed a new instrument named ‘OptoRheo’ that combines light sheet fluorescence microscopy with particle tracking microrheology. OptoRheo lets us image cells in 3D as they proliferate over several days while simultaneously sensing the mechanical properties of the surrounding extracellular and pericellular matrix at a sub-cellular length scale. OptoRheo can be used in two operational modalities (with and without an optical trap) to extend the dynamic range of microrheology measurements. We corroborated this by characterising the ECM surrounding live breast cancer cells in two distinct culture systems, cell clusters in 3D hydrogels and spheroids in suspension culture. This cutting-edge instrument will transform the exploration of drug transport through complex cell culture matrices and optimise the design of the next-generation of disease models.
Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression
Authors: Stålhammar Gustav , Gill Viktor Torgny 
Published: April 2023

AbstractBackgroundSeveral types of benign and malignant uveal melanocytes have been described based on their histological appearance. However, their characteristics have not been quantified, and their distribution during progression from normal choroidal melanocytes to primary tumors and metastases has not been reported.MethodsA total of 1,245,411 digitally scanned melanocytes from normal choroid, choroidal nevi, primary uveal melanomas, and liver metastases were entered into two-step cluster analyses to delineate cell types based on measured morphometric characteristics and expression of protein markers.ResultsHere we show that a combination of the area and circularity of cell nuclei, and BAP-1 expression in nuclei and cytoplasms yields the highest silhouette of cohesion and separation. Normal choroidal melanocytes and three types of uveal melanoma cells are outlined: Epithelioid (large, rounded nuclei; BAP-1 low; IGF-1R, IDO, and TIGIT high), spindle A (small, elongated nuclei; BAP-1 high; IGF-1R low; IDO, and TIGIT intermediate), and spindle B (large, elongated nuclei; BAP-1, IGF-1R, IDO, and TIGIT low). In normal choroidal tissue and nevi, only normal melanocytes and spindle A cells are represented. Epithelioid and spindle B cells are overrepresented in the base and apex, and spindle A cells in the center of primary tumors. Liver metastases contain no normal melanocytes or spindle A cells.ConclusionsFour basic cell types can be outlined in uveal melanoma progression: normal, spindle A and B, and epithelioid. Differential expression of tumor suppressors, growth factors, and immune checkpoints could contribute to their relative over- and underrepresentation in benign, primary tumor, and metastatic samples.
Self‐supervised pre‐training in photovoltaic systems via supervisory control and data acquisition data
Authors: Wang Dejun , Duan Zhenqing , Wang Wenbin , Chu Jingchun , Cui Qingru , Zhu Runze , Cui Yahui , Zhang You , You Zedong 
Published: April 2023

AbstractOwing to the availability of sensor data, the operation and maintenance (O&M) of sustainable energy systems have become more intelligent. In particular, data‐driven approaches have gained growing interest in supporting intelligent O&M. However, this is not a simple task, as the deficiency of labelled data poses a major challenge. This work proposes a self‐supervised pre‐training approach for autonomous learning of the Supervisory Control and Data Acquisition (SCADA) data representations for photovoltaic (PV) systems. Specifically, the proposed method first constructs the sample pairs using reasonable assumptions from a large volume of unlabelled SCADA data. Then, it designs a deep Siamese network to extract the representations of the input sample pair and sets the pretext task to measure whether the input pair is similar. The proposed method has been deployed in a PV system with nominal power 2.5 MW located in North China. Experimental results show that the proposed approach achieves accurate similarity assessment for the sample pairs and can potentially support downstream tasks regarding intelligent O&M.
EUSO-SPB2: A balloon experiment for UHECR and VHE neutrino observation
Authors: Cummings Austin , Eser Johannes , Filippatos George , Olinto Angela , Venters Tonia , Wiencke Lawrence ,   Collaboration
Published: April 2023

The Extreme Universe Space Observatory on a Super Pressure Balloon 2 (EUSO-SPB2) experiment will make new measurements from suborbital space as a precursor for future space missions that will address the challenge of the extremely low fluxes of ultra-high energy cosmic rays (UHECR) and very high energy (VHE) neutrinos.
The EUSO-SPB2 detector is comprised of two 1m diameter aperture telescopes. The Fluorescence Telescope (FT) will point in nadir and will record fluorescence light from cosmic ray EAS with energies above 1 EeV in its field of view of 36 by 12 degrees. The Cherenkov Telescope (CT) features a silicon photomultiplier focal surface with a field of view of 12 by 6 degrees. The CT will switch between two observation modes: one which points the CT above the limb to measure the Cherenkov emission of cosmic ray EAS with energies above 1 PeV and one which points the CT below the limb to record the Cherenkov emission produced by PeV scale EAS initiated by neutrino-sourced tau decay. As it is the first time such an instrument has been flown, one of the priorities of the CT will be the study of the optical background for observing neutrinos in this way.
EUSO-SPB2 is undergoing the final integration steps for launch on a NASA super pressure balloon payload in the spring of 2023 from Wanaka NZ. The CT was field-tested in March 2022 and the FT in August - September 2022.
The data collected during the EUSO-SPB2 mission will be essential to advancing the development of a space-based multi-messenger observatory such as the Probe of Extreme Multi-Messenger Astrophysics (POEMMA). In this contribution, we discuss the EUSO-SPB2 science goals, the instruments, the expected performance and the current status.
Influence of Hydrated Lime on the Self-Healing Capacity of Cement Mortars
Authors: Giordano Franco Grosso , Boon Nico , De Belie Nele 
Published: April 2023

The capacity of hydrated lime to reabsorb CO2as it hardens has made it a desirable replacement for cement to produce mortars with an overall lower environmental footprint. Still, research into lime-cement formulations remains limited, especially when it comes to their self-healing capacity.Some studies show that hydrated lime can improve self-healing in cement mixes, but addition rates are low. Here we present how high lime-cement ratios influence the self-healing capacity of lime mortars. Four mixes of increasing lime-cement ratios were cracked with tensile loading and placed under 1 hour wet, 23 hours dry cycles to stimulate self-healing. The mix design of 50 % lime-50 % cement volume (L50C50) showed self-healing abilities and was tested against a pure cement mixture (L0C100). Microscopy and water flow tests were performed at a cracking age of 7 days and then again after 28 days of healing in three regimes.Overall, submersion was the best healing regime for both L0C100 and L50C50 and crack self-healing was close to total (100 ± 1 % and 98 ± 6 %, respectively). Nevertheless, the water flow tests show that self-healing in L50C50 was in fact less efficient than that of the L0C100, achieving a 39 ± 21 % reduction in water flow versus 86 ± 11 %.
PVDF-based coatings with CNT additions for strain monitoring of mortar substrates subjected to bending
Authors: Milone Gabriele , Tulliani Jean-Marc , Al-Tabbaa Abir 
Published: April 2023

Sensing coatings are rapidly entering the field of non-destructive tests. While cement-based composites are proving an excellent interaction with new/recent structures, polymer-based coatings, already employed for structural retrofitting purposes, can provide a valuable alternative.
This study investigated the production, application, and use of poly(vinylidene fluoride) (PVDF) coatings. A 10w/v% PVDF-to-solvent ratio became the best trade-off between electrical conductivity and bond strength with the substrate. Different concentrations of Carbon Nanotubes (CNT) were investigated: 0.05, 0.10, 0.25, 0.50, and 0.75% by weight of PVDF. The conductive PVDF-CNT composites were brushed on the casted mortar beams with screws embedded as electrodes. The mortar beams and attached polymer coatings were then subjected to bending stress.
The Gauge Factor was obtained by comparing the substrate’s strain with the coating’s electric response. The sensing intervals in the Fractional Change of Resistance-strain curves varied in relation to the CNT concentration. For instance, adding 0.50w/v% of CNT gave the highest sensitivity up to 0.2‰ strain, followed by a lower – still sufficient – gauge factor. PVDF-based coatings with CNT additions of 0.25 and 0.75w/v% witnessed a comparable sensing performance in the same strain limits, abruptly increasing and finally stabilizing to a low gauge factor. In contrast, both 0.05 and 0.10w/v% resulted in a low monitoring potential overall.
The varying sensing zones experienced by the coating were attributed to the microscopical behavior of CNT within the PVDF matrix. In conclusion, the results highlighted the potentiality of polymeric coatings for sensing, monitoring, and inspection of concrete structures.
Status and prospects of HKG offshore market based on RMB internationalization: A non-linear regression model using Granger-causality test
Authors: Gao Lihong , Zhang Jing 
Published: April 2023

Over the past eighteen years, Hong Kong has developed the simple deposit business of the local RMB market into the world’s largest offshore RMB hub by virtue of its advantages as an international financial center.
Firstly, this paper introduces the specific situation of cross-border use of RMB, collects historical data on the offshore RMB market in Hong Kong through a desktop research approach, and reviews the development of the offshore RMB market in Hong Kong using the process of RMB internationalization as a clue. Secondly, the current opportunities and challenges facing the Hong Kong offshore RMB market are elucidated from three dimensions: demand, supply and exchange rate movements of RMB in the Hong Kong offshore market, respectively. To further illustrate the potential development of Hong Kong’s offshore market, this paper takes the development of offshore financial markets and RMB internationalization as a specific entry point, constructs a quantitative model, and obtains the conclusion that offshore financial markets have a positive impact on the internationalization process of RMB. On this basis, the paper illustrates the development potential of Hong Kong’s offshore market in the context of its specific situation. Finally, synthesizing the reflections in the whole paper, this paper makes certain analysis on the development direction of Hong Kong’s offshore market in the light of the blueprint of the national 14th Five-Year Plan.
Pluronic F-68 Montmorillonite As A Drug Delivery Vehicle For Extended
Release Of Venlafaxine Hydrochloride
Authors: Jain Shilpa , Datta Monika 
Published: April 2023

AbstractShort half-life and low bioavailability of Venlafaxine hydrochloride (VF), an
antidepressant drug, necessitates the frequent administration of VF tablets in a
day in order to maintain adequate drug concentration in blood plasma. This
generates the need for the development of formulations which could prolong the
release of VF and reduce the multiple dosages. The present work explores the
combination of Montmorillonite (Mt) with Pluronic F-68 (PF-68) (OrganoMT) for
oral delivery of VF. The effect of various parameters including pH of aqueous
drug solution, contact time and initial drug concentration on drug loading
capacity of OrganoMT has been studied. The synthesized OrganoMT-VF complexes
were characterized by various suitable techniques. XRD studies indicated that
the VF molecules were intercalated within the OrganoMT layers. In vitro release
behavior of VF from OrganoMT-VF complexes shows an extended-release pattern for
a period of 30 h and reaches upto 70% and 60% compared
to pure VF having complete release time of 5.5 h and 3.5 h in
simulated gastric and intestinal fluid respectively. Various kinetic models were
employed to elucidate the drug release mechanism where the best fitting was
obtained with Korsmeyer Peppas model. The results suggest the possibility of
designing an oral extended controlled release formulation for VF to minimize its
administration frequency thereby increasing the effectiveness of drug. This
improves patient compliance by reducing the dose from 4 times in 24 h to
once in 24 h.
Myxedema Heart Disease in a Teenage Child
Authors: Bennett Jean M. , Bridwell Rachel E. , Percival Candace S. , Malhotra Monesha Gupta , Appachi Elumalai , Salameh Mohammed 
Published: April 2023

AbstractMyxedema heart disease is an exceptionally rare condition with few reported cases. We present a rare case of a child who presented with severe congestive heart failure secondary to myxedema heart disease complicated by preexisting valvular heart disease. The patient was admitted to the pediatric intensive care unit and medical management. An echocardiogram showed severe biventricular dysfunction and severe valvular disease. She was started on levothyroxine and liothyronine. During the patient's hospitalization, the thyroxine level normalized but the thyroid-stimulating hormone continued to remain elevated. Likewise, her cardiac ventricular function improved, though it did not return to baseline. Our case highlights the importance of maintaining a broad differential diagnosis in a child who presents with congestive heart failure, to include thyroid disease, which necessitates a rare but specific management strategy.
Artemisinin and Ambrosia trifida extract aggravate the effects of short freeze–thaw stress in winter rye (Secale cereale) seedlings
Authors: Guo Jiancai , Bao Guozhang , Zhang Xin , Pan Xinyu , Zhao Hongwei , Fan Cunxin , Li Guomei 
Published: April 2023

The freeze–thaw and allelopathy from alien giant ragweed (Ambrosia trifida L.) and artemisinin have led to a serious stress to plants, influencing the agricultural quality and crop yield in north-east China. Yet, little is known how allelopathy affect plants under the freeze–thaw process. In this study, the characteristics in winter rye (Secale cereale L.) seedlings were investigated by laboratory simulation. The results showed that during the freezing process, application of artemisinin and A. trifida extract significantly increased the soluble protein content and accelerated lipid peroxidation, while they significantly inhibited antioxidant enzymes, photosynthesis and respiration (P < 0.05). During the thawing process, the freezing pressure decreased, and activities of antioxidant enzymes were significantly improved to mitigate artemisinin and A. trifida extract induced stress (P < 0.05). In addition, the sensitivity of the investigated metabolic processes in winter rye seedlings were highest to artemisinin and A. trifida extract in the freezing process. This study suggested that the stress response induced by artemisinin and A. trifida extract on winter rye seedlings in the freezing process was greater than that in the thawing process.
Modelling plants across scales of biological organisation for guiding crop improvement
Authors: Wu Alex 
Published: April 2023

Grain yield improvement in globally important staple crops is critical in the coming decades if production is to keep pace with growing demand; so there is increasing interest in understanding and manipulating plant growth and developmental traits for better crop productivity. However, this is confounded by complex cross-scale feedback regulations and a limited ability to evaluate the consequences of manipulation on crop production. Plant/crop modelling could hold the key to deepening our understanding of dynamic trait–crop–environment interactions and predictive capabilities for supporting genetic manipulation. Using photosynthesis and crop growth as an example, this review summarises past and present experimental and modelling work, bringing about a model-guided crop improvement thrust, encompassing research into: (1) advancing cross-scale plant/crop modelling that connects across biological scales of organisation using a trait dissection–integration modelling principle; (2) improving the reliability of predicted molecular–trait–crop–environment system dynamics with experimental validation; and (3) innovative model application in synergy with cross-scale experimentation to evaluate G × M × E and predict yield outcomes of genetic intervention (or lack of it) for strategising further molecular and breeding efforts. The possible future roles of cross-scale plant/crop modelling in maximising crop improvement are discussed.
Apple puree as a natural fructose source provides an effective alternative carbohydrate source for fuelling half‐marathon running performance
Authors: Reynolds Kirsty M. , Juett Loris A. , Funnell Mark P. , Schofield Joshua B. , Grundig Claire , Melidis George , Brown Alexander , Hubbard Will , Luo Yuxuan , Almahaireh Ibrahim , James Lewis J. , Mears Stephen A. 
Published: April 2023

ABSTRACTCarbohydrate supplementation during endurance exercise is known to improve performance, but the effects of food‐based approaches in running exercise are understudied. Therefore, this study investigated the performance and gastrointestinal (GI) effects of a carbohydrate supplement containing a natural fructose source compared with a highly processed fructose source in a combined glucose‐fructose supplement, during a half‐marathon. Eleven trained runners (9 males, 2 females; age 32 ± 8 y, 89:53 ± 13:28 min half‐marathon personal record) completed a familiarisation (8 miles) and two experimental trials (13.1 miles) on an outdoor running course, with blood and urine samples collected before and after the run. Subjective GI measures were made throughout the run. Carbohydrate was provided as a natural fructose source in the form of apple puree (AP) or highly processed crystalline fructose (GF) in a 2:1 glucose‐to‐fructose ratio (additional required glucose was provided through maltodextrin). Half‐marathon performance was not different between carbohydrate sources (AP 89:52 ± 09:33 min, GF 88:44 ± 10:09 min; P = 0.684). There were no interaction effects for GI comfort (P = 0.305) or other GI symptoms (P ≥ 0.211). There were no differences between carbohydrate sources in ad libitum fluid intake (AP 409 ± 206 mL; GF 294 ± 149 mL; P = 0.094) or any other urinary (P ≥ 0.724), blood‐based (P ≥ 0.215) or subjective (P ≥ 0.421) measures. Apple puree as a natural fructose source was equivalent to crystalline fructose in supporting half‐marathon running performance without increasing GI symptoms.
Periodic environmental effect: stochastic resonance in evolutionary games of rock-paper-scissors
Authors: Ma Hong-Yi , Liu Cong , Wu Zhi-Xi , Guan Jian-Yue 
Published: April 2023

Abstract
A balance in nature is maintained by the coexistence of multiple species through interspecific competition. The evolutionary dynamics of cyclic interactions contain interactions that represent different biological behaviors. Biological behavior is influenced by the external environment, which may affect the stability of ecosystems. We investigated the evolutionary dynamics of interspecific competition after a periodic change in the external environment affects species. We consider that when the periodic external environments affect mortality, interspecific cyclical competition may be more pronounced, and thus increase the probability of extinction of species. By performing Monte Carlo simulations, we observed that the evolutionary dynamics of interspecific cyclic competition have different responsivity when subjected to external periodic changes at different frequencies, and stochastic resonance phenomena occurred. We show that the influence of the periodic external environment and its frequency is one of the factors that determine whether ecosystems coexist stably.
Compton scattering of plasmons
Authors: Mendonça J Tito , Haas Fernando 
Published: April 2023

Abstract
We extend de concept of Compton scattering to the case of plasmons. This concept was originally applied to electrons in vacuum. Here, we consider electrons in a plasma, and study the scattering properties of photon-plasmon interactions. We show that a number n of plasmons with frequency ω ≃ ω

p
is scattered by an electron, for an incident photon with frequency

ω
′
≥

ω

p

, where ω

p
is the plasma frequency. We describe the general case of arbitrary n and assume that Compton scattering of plasmons is intrinsically a nonlinear process. Our theoretical model is based on Volkov solutions of the Klein–Gordon equation describing the state of relativistic electrons, when the spin is ignored. We derive the corresponding scattering probability, as well as the recoil formula associated with arbitrary final electron states. This process can be relevant to intense laser-plasma interactions.