bluuebunny/crossref_metadata_2025_split huggingface dataset:
An H2S‐BMP6 Dual‐Loading System with Regulating Yap/Taz and Jun Pathway for Synergistic Critical Limb Ischemia Salvaging Therapy
Authors: Hu Jiateng , Xu Zhijue , Liao Donghui , Jiang Yihong , Pu Hongji , Wu Zhaoyu , Xu Xintong , Zhao Zhen , Liu Jianqiang , Lu Xinwu , Liu Xiaobing , Li Bo 
Published: August 2023

AbstractCritical limb ischemia, the final course of peripheral artery disease, is characterized by an insufficient supply of blood flow and excessive oxidative stress. H2S molecular therapy possesses huge potential for accelerating revascularization and scavenging intracellular reactive oxygen species (ROS). Moreover, it is found that BMP6 is the most significantly up‐expressed secreted protein‐related gene in HUVECs treated with GYY4137, a H2S donor, based on the transcriptome analysis. Herein, a UIO‐66‐NH2@GYY4137@BMP6 co‐delivery nanoplatform to strengthen the therapeutic effects of limb ischemia is developed. The established UIO‐66‐NH2@GYY4137@BMP6 nanoplatform exerts its proangiogenic and anti‐oxidation functions by regulating key pathways. The underlying molecular mechanisms of UIO‐66‐NH2@GYY4137@BMP6 dual‐loading system lie in the upregulation of phosphorylated YAP/TAZ and Jun to promote HUVECs proliferation and downregulation of phosphorylated p53/p21 to scavenge excessive ROS. Meanwhile, laser‐doppler perfusion imaging (LDPI), injury severity evaluation, and histological analysis confirm the excellent therapeutic effects of UIO‐66‐NH2@GYY4137@BMP6 in vivo. This work may shed light on the treatment of critical limb ischemia by regulating YAP, Jun, and p53 signaling pathways based on gas‐protein synergistic therapy.
Formamidine Engineering the Lattice Distortion of Chiral Halide Perovskites for Efficient Blue Circularly Polarized Emission
Authors: Guan Qianwen , Ye Huang , Zhu Tingting , Zhang Xinyuan , You Shihai , Wu Jianbo , Zheng Youxuan , Liu Xitao , Luo Junhua 
Published: August 2023

AbstractChiral halide perovskites have emerged as promising circularly polarized light sources due to their great potential applications in 3D displays, optical data storage, and optical communication devices. However, to date, chiral halide perovskites with efficient blue circularly polarized luminescence (CPL) are scarcely unearthed. Herein, through formamidine engineering to decrease lattice distortion, the first new types of chiral corrugated 2D halide perovskites are presented (R/S)‐(BPEA)FAPbBr4·H2O (2‐R/S) (BPEA = 4‐bromophenylethylaminium, FA = formamidinium). Interestingly, driven by the incorporation of FA organic cations, the chiral perovskite layer realizes the transformation from (100)‐oriented (R/S)‐(BPEA)2PbBr4·H2O (1‐R/S) to (110)‐oriented 2‐R/S accompanying with reduced lattice distortion. More importantly, (110)‐oriented chiral perovskites 2‐R exhibit remarkable blue CPL with large asymmetry factors (glum =8.4 × 10−3). This work offers an exciting approach to realizing efficient blue CPL and promotes their further applications in photoelectronic devices.
Optimization of Thermoelectric Property of n‐Type Mg3Sb2 Near Room Temperature via Mn&Se Co‐Doping
Authors: Wang Runyu , Luo Siyun , Mo Xiaobo , Liu Hang , Liu Tong , Lei Xiaobo , Zhang Qinyong , Zhang Jianjun , Huang Lihong 
Published: August 2023

AbstractThe Bi2Te3 family has been considered a state‐of‐the‐art thermoelectric material for room‐temperature applications for over half a century. However, scarcity of the material Te has been a persistent issue. Recently, the discovery of n‐type Mg3(Bi, Sb)2‐based materials provides new hope for replacing traditional Bi2Te3, but their thermoelectric properties near room temperature still need improvement for application to practical devices. Herein, a competitive figure of merit of ≈0.8 at 300 K and a high power factor greater than 30 µW cm−1 K−2 at 300 K in n‐type Mg3.14Mn0.06Bi1.4Sb0.59Se0.01 is reported, benefiting from the rationally tuned carrier concentration of 2.29×1019 cm−3 at room temperature. Substituting the Mg site with Mn in Mg3.2Bi1.4Sb0.59Se0.01 changes the dominant carrier scattering mechanism from a mixed scattering of acoustic phonons and ionized impurities to acoustic phonon scattering. Mn doping in Mg3.2Bi1.4Sb0.59Se0.01 also enhances the mobility to 180 cm2 V−1 s−1, reduces the thermal conductivity, and significantly increases the quality factor β of the material. The high room temperature thermoelectric performance of n‐type Mn&Se co‐doped Mg3(Bi, Sb)2‐based materials makes them a highly competitive substitute for commercialized n‐type Bi2Te3.
Comparison of the effects of open and laparoscopic approach on body composition in gastrectomy for gastric cancer: A propensity score‐matched study
Authors: Takeoka Tomohira , Yamamoto Kazuyoshi , Kurokawa Yukinori , Miyazaki Yasuhiro , Kawabata Ryohei , Omori Takeshi , Imamura Hiroshi , Fujita Junya , Eguchi Hidetoshi , Doki Yuichiro 
Published: August 2023

AbstractAimTo compare the effects of open (OG) and laparoscopic gastrectomy (LG) on body composition and muscle strength.MethodsThis study performed a propensity score matching analysis using cases from a large‐scale, multicenter, phase III randomized controlled trial concerning oral nutritional supplements after gastrectomy and analyzed both the whole and matched cohorts. Measurements of body composition and hand grip strength (HGS) were performed at baseline (preoperatively) and at 1, 2, 3, 6, and 12 months after gastrectomy.ResultsOf 835 patients, 275 and 560 underwent OG and LG, respectively. Skeletal muscle mass (SMM) and HGS loss were significantly lesser in the LG group than in the OG group. The propensity score‐matched analysis, including 120 pairs of patients, confirmed that the % SMM loss values at 1, 2, 3, 6, and 12 POM were −4.5%, −4.0%, −4.7%, −4.6%, and −5.8% in the OG group and −3.0%, −1.9%, −2.4%, −2.2%, and −2.7% in the LG group, respectively. The % SMM loss was significantly lesser in the LG group than in the OG group (repeated measures ANOVA p < 0.001). The HGS loss was non‐significantly smaller in the LG group than in the OG group.ConclusionSkeletal muscle mass loss was significantly lesser in the LG group than in the OG group in both cohorts, indicating that LG may be more effective than OG for maintaining muscle mass.
Low anterior resection syndrome: Incidence and association with quality of life
Authors: Homma Yuko , Mimura Toshiki , Koinuma Koji , Horie Hisanaga , Lefor Alan Kawarai , Sata Naohiro 
Published: August 2023

AbstractAimLow anterior resection syndrome (LARS) causes devastating symptoms and impairs quality of life (QOL). Although its incidence and risk factors have been reported, these data are scarce in Japan. This study aimed to elucidate the incidence and risk factors of LARS as well as to evaluate its association with QOL in Japanese patients.MethodPatients with anal defecation at the time of the survey between November 2020 and April 2021 were included, among those who underwent anus‐preserving surgery for rectal tumors between 2014 and 2019 in tertiary referral university hospital. The severity of LARS and QOL were evaluated with the LARS score and the Japanese version of the fecal incontinence quality of life scale (JFIQL), respectively. Primary endpoint was the incidence of major LARS. Secondary endpoints were risk factors and association with JFIQL.ResultsOf 332 eligible patients, 238 (71.7%) answered the LARS survey completely. The incidence of major LARS was 22% overall, and 48% when limited to lower tumors. Independent risk factors included lower tumors (OR: 7.0, 95% CI: 2.1–23.1, p = 0.001) and surgical procedures with lower anastomoses (OR: 4.6, 95% CI: 1.2–18.5, p = 0.03). The JFIQL generic score correlated moderately with the LARS score (correlation coefficient of −0.65). The JFIQL generic score was also significantly lower in lower tumors.ConclusionsThe incidence of major LARS is 22% in Japanese patients, and independent risk factors include lower tumors and surgical procedures with lower anastomoses. More severe LARS is associated with worse QOL which is significantly more impaired in patients with lower tumors.
Four mesothelioma cases from a single automotive dealership: A case series
Authors: Frank Arthur L. 
Published: August 2023

AbstractBackgroundFour cases of mesothelioma were noted in a workplace of some 110 persons at a tractor dealership between 2006 and 2023. Each worker had a different job title.MethodsMedical‐legal case material was reviewed and abstracted from four cases from the same dealership, all supplied via one law firm.ResultsFour mesotheliomas are reported from this single facility that used chrysotile asbestos automotive products. Two of the four cases had no other known exposures to asbestos.DiscussionAutomotive products containing chrysotile do appear capable of causing mesothelioma. Job category is not a good surrogate for exposure.
Genetic Modifiers of Age at Onset for Amyotrophic Lateral Sclerosis: A Genome‐Wide Association Study
Authors: Li Chunyu , Lin Junyu , Jiang Qirui , Yang Tianmi , Xiao Yi , Huang Jingxuan , Hou Yanbing , Wei Qianqian , Cui Yiyuan , Wang Shichan , Zheng Xiaoting , Ou Ruwei , Liu Kuncheng , Chen Xueping , Song Wei , Zhao Bi , Shang Huifang 
Published: August 2023

ObjectiveAge at onset (AAO) is an essential clinical feature associated with disease progression and mortality in amyotrophic lateral sclerosis (ALS). Identification of genetic variants and environmental risk factors influencing AAO of ALS could help better understand the disease's biological mechanism and provide clinical guidance. However, most genetic studies focused on the risk of ALS, while the genetic background of AAO is less explored. This study aimed to identify genetic and environmental determinants for AAO of ALS.MethodsWe performed a genome‐wide association analysis using a Cox proportional hazards model on AAO of ALS in 10,068 patients. We further conducted colocalization analysis and in‐vitro functional exploration for the target variants, as well as Mendelian randomization analysis to identify risk factors influencing AAO of ALS.ResultsThe total heritability of AAO of ALS was ~0.16 (standard error [SE] = 0.03). One novel locus rs2046243 (CTIF) was significantly associated with earlier AAO by ~1.29 years (p = 1.68E‐08, beta = 0.10, SE = 0.02). Functional exploration suggested this variant was associated with increased expression of CTIF in multiple tissues including the brain. Colocalization analysis detected a colocalization signal at the locus between AAO of ALS and expression of CTIF. Causal inference indicated higher education level was associated with later AAO.InterpretationThese findings improve the current knowledge of the genetic and environmental etiology of AAO of ALS, and provide a novel target CTIF for further research on ALS pathogenesis and potential therapeutic options to delay the disease onset. ANN NEUROL 2023;94:933–941
Microglial and Astrocytic Responses in the Human Midcingulate Cortex in Huntington's Disease
Authors: Palpagama Thulani , Mills Aimee Rose , Ferguson Mackenzie Wendy , Vikas Ankeal Praju , Turner Clinton , Tippett Lynette , van der Werf Bert , Waldvogel Henry John , Faull Richard Lewis Maxwell , Kwakowsky Andrea 
Published: August 2023

ObjectivePatients with Huntington's disease can present with variable difficulties of motor functioning, mood, and cognition. Neurodegeneration occurs in the anterior cingulate cortex of some patients with Huntington's disease and is linked to the presentation of mood symptomatology. Neuroinflammation, perpetrated by activated microglia and astrocytes, has been reported in Huntington's disease and may contribute to disease progression and presentation. This study sought to quantify the density of mutant huntingtin protein and neuroinflammatory glial changes in the midcingulate cortex of postmortem patients with Huntington's disease and determine if either correlates with the presentation of mood, motor, or mixed symptomatology.MethodsFree‐floating immunohistochemistry quantified 1C2 immunolabeling density as an indicative marker of mutant huntingtin protein, and protein and morphological markers of astrocyte (EAAT2, Cx43, and GFAP), and microglial (Iba1 and HLA‐DP/DQ/DR) activation. Relationships among the level of microglial activation, mutant huntingtin burden, and case characteristics were explored using correlative analysis.ResultsWe report alterations in activated microglia number and morphology in the midcingulate cortex of Huntington's disease cases with predominant mood symptomatology. An increased proportion of activated microglia was observed in the midcingulate of all Huntington's disease cases and positively correlated with 1C2 burden. Alterations in the astrocytic glutamate transporter EAAT2 were observed in the midcingulate cortex of patients associated with mood symptoms.InterpretationThis study presents pathological changes in microglia and astrocytes in the midcingulate cortex in Huntington's disease, which coincide with mood symptom presentation. These findings further the understanding of neuroinflammation in Huntington's disease, a necessary step for developing inflammation‐targeted therapeutics. ANN NEUROL 2023;94:895–910
A Radical Pathway and Stabilized Li Anode Enabled by Halide Quaternary Ammonium Electrolyte Additives for Lithium‐Sulfur Batteries
Authors: Meng Ruijin , He Xin , Ong Samuel Jun Hoong , Cui Chenxu , Song Shufeng , Paoprasert Peerasak , Pang Quanquan , Xu Zhichuan J. , Liang Xiao 
Published: August 2023

AbstractPassivation of the sulfur cathode by insulating lithium sulfide restricts the reversibility and sulfur utilization of Li−S batteries. 3D nucleation of Li2S enabled by radical conversion may significantly boost the redox kinetics. Electrolytes with high donor number (DN) solvents allow for tri‐sulfur (S3⋅−) radicals as intermediates, however, the catastrophic reactivity of such solvents with Li anodes pose a great challenge for their practical application. Here, we propose the use of quaternary ammonium salts as electrolyte additives, which can preserve the partial high‐DN characteristics that trigger the S3⋅− radical pathway, and inhibit the growth of Li dendrites. Li−S batteries with tetrapropylammonium bromide (T3Br) electrolyte additive deliver the outstanding cycling stability (700 cycles at 1 C with a low‐capacity decay rate of 0.049 % per cycle), and high capacity under a lean electrolyte of 5 μLelectrolyte mgsulfur−1. This work opens a new avenue for the development of electrolyte additives for Li−S batteries.
Effect of fiber orientation and fiber volume fraction on the mechanical properties of all‐polyamide composites
Authors: Cordin Michael , Manian Avinash P. , Bechtold Thomas , Pham Tung 
Published: August 2023

AbstractThermoplastic all‐polymer composites (with reinforcing fibers and matrix material made of the same material) have attracted strong interest in recent years, because they provide big potential in recycling after usage over the traditional composites with inorganic reinforcements. The present work investigates a new preparation concept of all‐polyamide composites, based on intermingled hybrid yarn of polyamide‐6 and polyamide‐66 fibers. Composites with desired reinforcing fiber orientation can be prepared by technical embroidering of the hybrid yarn in the desired direction on a polyamide‐6 fabric. The composite is then prepared by thermoforming at 230°C, ensuring the intact reinforcing and unmelted PA66 fibers embedding in a molten PA6 matrix. Therefore this preparation concept is based on the different melting temperature of PA6 and PA66. The mechanical properties of composites with different ratio between matrix and reinforcement material and different reinforcing fiber orientation are characterized with quasi‐static and high‐speed tensile and with penetration tests.
Zinc methionine improves the lipid metabolism that is associated with the alteration of intestine mucosal proteomes and microbiota of newborn Holstein dairy calves
Authors: Yu Xin , Wo Yeqianli , Ma Fengtao , Shan Qiang , Wei Jingya , Sun Peng 
Published: August 2023

AbstractSupplementation of diets with a modest amount of zinc methionine (ZM) has been documented to improve the growth performance and antioxidant function of dairy calves, but the underlying mechanisms remain elusive. In the present study, 16 dairy calves were allocated to a control (CON) group (calves consumed a basal diet) and a ZM group (calves ingested the basal diet and had an additional 455 mg ZM/day, corresponding to 80 mg zinc/day). The calves were fed these diets for 2 weeks, after which their serum antioxidant parameters, lipids, and jejunal mucosal proteome and microbiota were analyzed. The ZM group had lower levels of total cholesterol, triglycerides, and malondialdehyde but higher high‐density lipoprotein cholesterol and glutathione peroxidase activity in the serum. A total of 142 differentially expressed proteins in the intestinal mucosa between the CON and ZM groups had been identified (ZM upregulated 117 proteins and downregulated 25 proteins). In addition, the protein expression of acyl‐coenzyme A oxidase 1, fatty acid binding protein 2, and peroxisome proliferator‐activated receptor gamma was higher in the ZM group. 16S rRNA gene sequencing indicated beneficial microbes, such as Veillonellaceae, Akkermansia_muciniphila, and Bifidobacterium adolescentis, which were more abundant, whereas Acinetobacter lwoffii was less abundant in calf jejunal mucosa in the ZM group. Finally, the propionate, butyrate, and iso‐valerate concentrations in the jejunal digesta were greater in the ZM group than those in the CON group. Collectively, the present study shows that ZM supplementation improves the serum and intestine mucosal lipid metabolism associated with the alterations in mucosal fatty acids β‐oxidation and microbiota.
Mobility‐aware optimal trade planning and mean field game‐based decentralized charging control for large‐scale electric vehicles
Authors: Xu Fuguo , Zhao Kai , Fu Qiaobin 
Published: August 2023

AbstractThe uncertainty mobility characteristics of electric vehicles (EVs) are a key factor that influence the charging station trade income with the power grid. In this paper, a hierarchical energy management strategy is proposed for charging stations when large‐scale EVs are considered. The traveling and parking mobility characteristics of EVs are first extracted by analyzing historical real‐world traveling data. Then, a day‐ahead power trade planning strategy between the grid and charging station to maximize incomes is developed by solving a mixed‐integer linear programming problem. Furthermore, based on EV mobility characteristics, clusters are generated to classify different parking behaviors, where a mean field game‐based decentralized charging control scheme for individual EVs in each cluster is employed. The target of the proposed optimal charging controller is to guarantee the charging power tracking performance and the power demand of individual EV at the terminal time for subsequent travel. Finally, simulations on MATLAB/Simulink platform are conducted to show the effectiveness of the proposed hierarchical energy management strategy.
Prospective therapeutics for intestinal and hepatic fibrosis
Authors: Li Xin , Yu Mengli , Zhao Qingwei , Yu Yang 
Published: August 2023

AbstractCurrently, there are no effective therapies for intestinal and hepatic fibrosis representing a considerable unmet need. Breakthroughs in pathogenesis have accelerated the development of anti‐fibrotic therapeutics in recent years. Particularly, with the development of nanotechnology, the harsh environment of the gastrointestinal tract and inaccessible microenvironment of fibrotic lesions seem to be no longer considered a great barrier to the use of anti‐fibrotic drugs. In this review, we comprehensively summarize recent preclinical and clinical studies on intestinal and hepatic fibrosis. It is found that the targets for preclinical studies on intestinal fibrosis is varied, which could be divided into molecular, cellular, and tissues level, although little clinical trials are ongoing. Liver fibrosis clinical trials have focused on improving metabolic disorders, preventing the activation and proliferation of hepatic stellate cells, promoting the degradation of collagen, and reducing inflammation and cell death. At the preclinical stage, the therapeutic strategies have focused on drug targets and delivery systems. At last, promising remedies to the current challenges are based on multi‐modal synergistic and targeted delivery therapies through mesenchymal stem cells, nanotechnology, and gut‐liver axis providing useful insights into anti‐fibrotic strategies for clinical use.
Isoelectric point (pI)‐based phase separation (pI‐BPS) purification of elastin‐like polypeptides (ELPs) containing charged, biologically active fusion proteins (ELP‐FPs)
Authors: Roland Truman J. , Strauss Graham L. , Bushra Nabila , Muschol Martin , Koria Piyush 
Published: August 2023

AbstractElastin‐like polypeptides (ELPs) are peptide‐based biomaterials with residue sequence (VPGXG)n where X is any residue except proline. ELPs are a useful modality for delivering biologically active proteins (growth factors, protease inhibitors, anti‐inflammatory peptides, etc.) as fusion proteins (ELP‐FP). ELP‐FPs are particularly cost‐effective because they can be rapidly purified using Inverse Temperature Cycling (ITC) via the reversible formation and precipitation of entropically driven aggregates above a transition temperature (Tt). When ELP fusion proteins (ELP‐FPs) contain significant charge density at physiological pH, electrostatic repulsion between them severely inhibits aggregate formation. The literature does not currently describe methods for purifying ELP‐FPs containing charged proteins on either side of the ELP sequence as fusion partners without organic solvents. Here, the isoelectric point (pI) of ELP‐FPs is discussed as a means of neutralizing surface charges on ELP‐FPs and increasing ITC yield to dramatically high levels. We use pI‐based phase separation (pI‐BPS) to purify ELP‐FPs containing cationic and anionic fusion proteins. We report a dramatic increase in protein yield when using pI‐BPS for purification of ELP‐FPs. Proteins purified by this method also retain the functional activity of the protein present in the ELP‐FP. Techniques developed here enable significant diversification of possible fusion proteins delivered by ELPs as ELP‐FPs by allowing them to be produced and purified at higher quantities and yields.
Positive and negative contact between Africans and native Italians: Importance for migrants' collective action in support of their and other groups' rights
Authors: Prati Francesca , Kenfack Corine Stella Kana , Hewstone Miles , Rubini Monica 
Published: August 2023

AbstractThis research investigates the positive and negative contact experiences of African migrants with native Italians and the association between contact and behavioural intentions to reduce social inequalities. Two studies examined the associations between intergroup contact of migrants and their collective action in support of their or other group members, by testing the mediating role of positive and negative emotions towards natives. Hypotheses were tested with two samples of first‐generation, legal African migrants living in Italy for less than 3 years (Ns = 242 [118 males], 251 [154]). Negative contact was positively associated with collective action in support of one's group, especially among respondents with higher positive intergroup experiences, and anger towards native people mediated this association. The association of positive contact with collective action to foster a more egalitarian society in general was mediated by reduced fear towards native people, and the association between positive contact and collective action at large was stronger for migrants with lower negative intergroup contact. Overall, this research provides further evidence on the impact of intergroup contact on migrants, specifically on the role of affective factors in their association with migrants' willingness to engage in collective action to reduce societal inequality at large.