bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boron nitride quantum dots modified carbon-defects ultra-thin porous carbon nitride: double channels and quantum size effects facilitate photogenerated carrier migration and exciton dissociation
Authors: Huang Chugeng , Wu Dandan , Jiang Guojian 
Published: March 2023

Abstract
Graphite carbon nitride possesses great promise for visible photocatalysis, but the bulk carbon nitride prepared from nitrogen-rich precursors such as melamine has inherent drawbacks such as retarded photogenerated carrier migration and exciton effects, which limit its application. Herein, we constructed a novel Boron nitride quantum dots modified carbon-defects ultra-thin porous carbon nitride (BNQDs/Vc-UPCN). The double channels were constructed by carbon-defects structure and Boron nitride quantum effect to overcome its inherent drawbacks and applied to the photodegradation of common persistent organic pollutants (methylene blue). The structure, porosity, elemental composition, optical properties, photoelectrochemical properties, and photocatalytic properties of the prepared BNQDs/Vc-UPCN composites were investigated using various characterization methods. Meanwhile, the results of radical trapping experiments and electron spin resonance characterization demonstrated that BNQDs/Vc-UPCN promote molecular oxygen activation more than Vc-UPCN did. In terms of degradation effect, the best sample (BC-1) is 10 times more effective than the initial sample (BCN). This study proposes an effective mechanism for constructing novel visible-light-driven photocatalysts using carbon-defects ultra-thin structures and quantum dots, which can be used for the treatment of organic pollutants.
Literary City Limits: Cognitive Mapping in Contemporary Marseille
Authors: Kelly Michael G 
Published: March 2023

Abstract
Marseille can be thought to constitute a singular urban complex – both marginal and transitional – within a broader French territorial imaginary and political discourse. Proposing successive readings of literary works by Emmanuel Loi (Marseille amor, 2013), Sabrina Calvo (Sous la colline, 2015) and Maylis de Kerangal (Corniche Kennedy, 2008), this article examines how such works mobilize aspects of this singularity in the development of striking and occasionally ambivalent utopian problematics, reframing the city with respect to a set of vectors (both temporal and spatial) that expose the subject to the troubling horizons of both individual and collective agency. The article reflects on the specific parameters of a ‘space of possibility’ in the urban context under discussion. Moving from this localized problematic, it argues for a version of cognitive mapping that incorporates varieties of affective disposition key to the relations of reason and emotion in a utopian perspective: melancholy, curiosity and disobedience.
Social experience and pheromone receptor activity reprogram gene expression in sensory neurons
Authors: Deanhardt Bryson , Duan Qichen , Du Chengcheng , Soeder Charles , Morlote Alec , Garg Deeya , Saha Aishani , Jones Corbin D , Volkan Pelin Cayirlioglu 
Published: March 2023

Abstract
Social experience and pheromone signaling in olfactory neurons affect neuronal responses and male courtship behaviors in Drosophila. We previously showed that social experience and pheromone signaling modulate chromatin around behavioral switch gene fruitless, which encodes a transcription factor necessary and sufficient for male sexual behaviors. Fruitless drives social experience-dependent modulation of courtship behaviors and physiological sensory neuron responses to pheromone; however, the molecular mechanisms underlying this modulation of neural responses remain less clear. To identify the molecular mechanisms driving social experience-dependent changes in neuronal responses, we performed RNA-seq from antennal samples of mutants in pheromone receptors and fruitless, as well as grouped or isolated wild-type males. Genes affecting neuronal physiology and function, such as neurotransmitter receptors, ion channels, ion and membrane transporters, and odorant binding proteins are differentially regulated by social context and pheromone signaling. While we found that loss of pheromone detection only has small effects on differential promoter and exon usage within fruitless gene, many of the differentially regulated genes have Fruitless binding sites or are bound by Fruitless in the nervous system. Recent studies showed that social experience and juvenile hormone signaling co-regulate fruitless chromatin to modify pheromone responses in olfactory neurons. Interestingly, genes involved in juvenile hormone metabolism are also misregulated in different social contexts and mutant backgrounds. Our results suggest that modulation of neuronal activity and behaviors in response to social experience and pheromone signaling likely arise due to large-scale changes in transcriptional programs for neuronal function downstream of behavioral switch gene function.
Effects of Controlled Supramaximal High-Intensity Interval Training on Cardiorespiratory Fitness and Global Cognitive Function in Older Adults: The Umeå HIT Study—A Randomized Controlled Trial
Authors: Simonsson Emma , Levik Sandström Sofi , Hedlund Mattias , Holmberg Henrik , Johansson Bengt , Lindelöf Nina , Boraxbekk Carl-Johan , Rosendahl Erik 
Published: March 2023

Abstract

Background
This study examined the effects of regulated and controlled supramaximal high-intensity interval training (HIT) adapted for older adults, compared to moderate-intensity training (MIT), on cardiorespiratory fitness; cognitive, cardiovascular, and muscular function; and quality of life.

Methods
Sixty-eight nonexercising older adults (66–79 years, 44% males) were randomized to 3 months of twice-weekly HIT (20-minute session including 10 × 6-second intervals) or MIT (40-minute session including 3 × 8-minute intervals) on stationary bicycles in an ordinary gym setting. Individualized target intensity was watt controlled with a standardized pedaling cadence and individual adjustment of the resistance load. Primary outcomes were cardiorespiratory fitness (V̇o2peak) and global cognitive function (unit-weighted composite).

Results
V̇o2peak increased significantly (mean 1.38 mL/kg/min, 95% CI [0.77, 1.98]), with no between-group difference (mean difference 0.05 [−1.17, 1.25]). Global cognition did not improve (0.02 [−0.05, 0.09]), nor differed between groups (0.11 [−0.03, 0.24]). Significant between-group differences in change were observed for working memory (0.32 [0.01, 0.64]), and maximal isometric knee extensor muscle strength (0.07 N·m/kg [0.003, 0.137]), both in favor of HIT. Irrespective of the group, there was a negative change in episodic memory (−0.15 [−0.28, −0.02]), a positive change in visuospatial ability (0.26 [0.08, 0.44]), and a decrease in systolic (−2.09 mmHg [−3.54, −0.64]) and diastolic (−1.27 mmHg [−2.31, −0.25]) blood pressure.

Conclusions
In nonexercising older adults, 3 months of watt-controlled supramaximal HIT improved cardiorespiratory fitness and cardiovascular function to a similar extent as MIT, despite half the training time. In favor of HIT, there was an improvement in muscular function and a potential domain-specific effect on working memory.

Clinical Trial Registration
NCT03765385
Dual Functionality in Later Life
Authors: Ferraro Kenneth F , Bauldry Shawn , Sauerteig-Rolston Madison R , Thomas Patricia A 
Published: March 2023

Abstract
Gerontologists have long shown interest in both longevity and quality of life during later life, but considerable debate has ensued as scholars sought to integrate the two. Drawing from research on the topics of exceptional longevity, successful aging, and active life expectancy, we propose the concept of dual functionality to examine how humans reach advanced ages while maintaining physical and cognitive function. Dual functionality refers to being free of both physical and cognitive impairment. The loss of dual functionality challenges social networks to respond to the functional loss and is a harbinger of additional losses. Evidence of change in the percent of the older population maintaining dual functionality would be helpful for evaluating public health policies to aid quality of life during later life. This article is based on the first author’s Robert W. Kleemeier Award Lecture at The Gerontological Society of America 2022 Annual Scientific Meeting.
Resequencing of a Pekin duck breeding population provides insights into the genomic response to short-term artificial selection
Authors: Yu Simeng , Liu Zihua , Li Ming , Zhou Dongke , Hua Ping , Cheng Hong , Fan Wenlei , Xu Yaxi , Liu Dapeng , Liang Suyun , Zhang Yunsheng , Xie Ming , Tang Jing , Jiang Yu , Hou Shuisheng , Zhou Zhengkui 
Published: March 2023

Abstract

Background
Short-term, intense artificial selection drives fast phenotypic changes in domestic animals and leaves imprints on their genomes. However, the genetic basis of this selection response is poorly understood. To better address this, we employed the Pekin duck Z2 pure line, in which the breast muscle weight was increased nearly 3-fold after 10 generations of breeding. We denovo assembled a high-quality reference genome of a female Pekin duck of this line (GCA_003850225.1) and identified 8.60 million genetic variants in 119 individuals among 10 generations of the breeding population.

Results
We identified 53 selected regions between the first and tenth generations, and 93.8% of the identified variations were enriched in regulatory and noncoding regions. Integrating the selection signatures and genome-wide association approach, we found that 2 regions covering 0.36 Mb containing UTP25 and FBRSL1 were most likely to contribute to breast muscle weight improvement. The major allele frequencies of these 2 loci increased gradually with each generation following the same trend. Additionally, we found that a copy number variation region containing the entire EXOC4 gene could explain 1.9% of the variance in breast muscle weight, indicating that the nervous system may play a role in economic trait improvement.

Conclusions
Our study not only provides insights into genomic dynamics under intense artificial selection but also provides resources for genomics-enabled improvements in duck breeding.
Honey bee (Apis mellifera) wing images: a tool for identification and conservation
Authors: Oleksa Andrzej , Căuia Eliza , Siceanu Adrian , Puškadija Zlatko , Kovačić Marin , Pinto M Alice , Rodrigues Pedro João , Hatjina Fani , Charistos Leonidas , Bouga Maria , Prešern Janez , Kandemir İrfan , Rašić Slađan , Kusza Szilvia , Tofilski Adam 
Published: March 2023

Abstract

Background
The honey bee (Apis mellifera) is an ecologically and economically important species that provides pollination services to natural and agricultural systems. The biodiversity of the honey bee in parts of its native range is endangered by migratory beekeeping and commercial breeding. In consequence, some honey bee populations that are well adapted to the local environment are threatened with extinction. A crucial step for the protection of honey bee biodiversity is reliable differentiation between native and nonnative bees. One of the methods that can be used for this is the geometric morphometrics of wings. This method is fast, is low cost, and does not require expensive equipment. Therefore, it can be easily used by both scientists and beekeepers. However, wing geometric morphometrics is challenging due to the lack of reference data that can be reliably used for comparisons between different geographic regions.

Findings
Here, we provide an unprecedented collection of 26,481 honey bee wing images representing 1,725 samples from 13 European countries. The wing images are accompanied by the coordinates of 19 landmarks and the geographic coordinates of the sampling locations. We present an R script that describes the workflow for analyzing the data and identifying an unknown sample. We compared the data with available reference samples for lineage and found general agreement with them.

Conclusions
The extensive collection of wing images available on the Zenodo website can be used to identify the geographic origin of unknown samples and therefore assist in the monitoring and conservation of honey bee biodiversity in Europe.
Building Cetacean Locomotor Muscles throughout Ontogeny to Support High-Performance Swimming into Adulthood
Authors: Noren S R 
Published: March 2023

Synopsis
The demands on the locomotor muscles at birth are different for cetaceans than terrestrial mammals. Cetacean muscles do not need to support postural costs as the neonate transitions from the womb because water’s buoyant force supports body weight. Rather, neonatal cetacean muscles must sustain locomotion under hypoxic conditions as the neonate accompanies its mother swimming underwater. Despite disparate demands at birth, cetaceans like terrestrial mammals require postnatal development to attain mature musculature. Neonatal cetaceans have a low proportion of muscle mass, and their locomotor muscles have lower mitochondrial density, myoglobin content (Mb), and buffering capacity than those found in the adult locomotor muscle. For example, the locomotor muscle of the neonatal bottlenose dolphin has only 10 and 65% of the Mb and buffering capacity, respectively, found in the adult locomotor muscle. The maturation period required to achieve mature Mb and buffering capacity in the locomotor muscle varies across cetacean species from 0.75 to 4 and 1.17 to 3.4 years, respectively. The truncated nursing interval of harbor porpoises and sub-ice travel of beluga whales may be drivers for faster muscle maturation in these species. Despite these postnatal changes in the locomotor muscle, ontogenetic changes in locomotor muscle fiber type seem to be rare in cetaceans. Regardless, the underdeveloped aerobic and anaerobic capacities of the locomotor muscle of immature dolphins result in diminished thrusting capability and swim performance. Size-specific stroke amplitudes (23–26% of body length) of 0–3-month-old dolphins are significantly smaller than those of &gt;10-month-olds (29–30% of body length), and 0–1-month-olds only achieve 37 and 52% of the mean and maximum swim speed of adults, respectively. Until swim performance improves with muscle maturation, young cetaceans are precluded from achieving their pod’s swim speeds, which could have demographic consequences when fleeing anthropogenic disturbances.
Oridonin inhibits Hela cell proliferation via downregulation of glutathione metabolism: a new insight from metabolomics
Authors: Wang Weijia , Zhang Nan 
Published: March 2023

Abstract

Objectives
This study aims to elucidate Oridonin' s inhibitory mechanism to cervical cancer using metabolomics methods and pharmacological assays.

Methods
Network pharmacology and KEGG pathway analysis are used to identify overlapped targets and involved metabolic pathways. UPLC-MS/MS metabolomics analysis is used to determine altered metabolites after Oridonin treatment. Other bioassays are also employed to uncover the changes in critical molecules that are highly related to altered metabolites.

Key findings
Seventy-five overlapped targets are identified between Oridonin and cervical cancer. Twenty-one metabolites involved in tricarboxylic acid cycle glutathione metabolism, branched-chain amino acid metabolism and so on changes significantly after Oridonin treatment. Oridonin treatment significantly reduces the content of cysteine and inhibit the catalytic activity of glutamine–cysteine ligase subunit, a rate-limiting enzyme for the synthesis of glutathione. As a result, the content of glutathione is also reduced. The antioxidant enzyme glutathione peroxidase 4 which uses glutathione as a cofactor, is inactivated, resulting in a burst release of reactive oxygen species. The ATP content is also significantly reduced in Hela cells after Oridonin treatment.

Conclusions
This study finds that Oridonin treatment induces Hela cell apoptosis possibly via inhibition of the glutathione metabolism.
Safe for Whom? A Human Security Perspective on Nigeria as a ‘Safe Country of Origin’
Authors: Creed Xander , Kaşlı Zeynep , Jaysundara-Smits Shyamika 
Published: March 2023

Abstract
There has been a proliferation of readmission agreements and voluntary return programmes between the EU, its members and third countries, in which non-state actors play an increasing role. Based on the case of return to Nigeria, this article develops a discursive account of human security conditions in Nigeria to identify the changes and continuities over time in the diverse representations of what constitutes conditions suitable for a safe, dignified return. Our study shows that discourses in favour of return to Nigeria, despite nuances and shifts over time, have remained predominantly and persistently focused on economic, political, individual and community security and entirely overlook the growing challenges of food and environmental (in)security—hence failing to fully consider conditions constituting ‘safe return’ or nonrefoulement. Our findings challenge what is discursively constructed as ‘safe’ in return policies and practices and suggest that durable policy solutions require paying attention to multidimensional human security conditions.
Testing dark energy models with gamma-ray bursts calibrated from the observationalH(z) data through a Gaussian process
Authors: Li Zihao , Zhang Bin , Liang Nan 
Published: March 2023

ABSTRACTWe use a cosmology-independent method to calibrate gamma-ray burst (GRB) from the observational Hubble data (OHD) with the cosmic chronometer method. By using Gaussian process to reconstruct OHD, we calibrate the Amati relation (Ep–Eiso) to construct a GRB Hubble diagram with the A118 data set, and constrain dark energy models in a flat space with the Markov chain Monte Carlo numerical method. With the cosmology-independent GRBs at 1.4 &lt; z ≤ 8.2 in the A118 data set and the Pantheon sample of Type Ia supernovae at 0.01 &lt; z ≤ 2.3, we obtained Ωm = $0.379^{+0.033}_{-0.024}$, h = $0.701^{+0.0035}_{-0.0035}$, w = $-1.25^{+0.14}_{-0.12}$, and wa = $-0.84^{+0.81}_{-0.38}$ for the flat Chevallier–Polarski–Linder model at the 1σ confidence level. We find no significant evidence supporting deviations from the standard Lambda cold dark matter model.
Massive prompt cusps: a new signature of warm dark matter
Authors: Delos M Sten 
Published: March 2023

ABSTRACT
Every dark matter halo and subhalo is expected to have a prompt ρ ∝ r−1.5 central density cusp, which is a relic of its condensation out of the smooth mass distribution of the early Universe. The sizes of these prompt cusps are linked to the scales of the peaks in the initial density field from which they formed. In warm dark matter (WDM) models, the smoothing scale set by free streaming of the dark matter can result in prompt cusps with masses of order 107 M⊙. We show that WDM models with particle masses ranging from 2 to 6 keV predict prompt cusps that could detectably alter the observed kinematics of Local Group dwarf galaxies. Thus, prompt cusps present a viable new probe of WDM. A prompt cusp’s properties are highly sensitive to when it formed, so prospects can be improved with a better understanding of when the haloes of the Local Group dwarfs originally formed. Tidal stripping can also affect prompt cusps, so constraints on satellite galaxy orbits can further tighten WDM inferences.
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins
Authors: Hatos Andras , Teixeira João M C , Barrera-Vilarmau Susana , Horvath Attila , Tosatto Silvio C E , Vendruscolo Michele , Fuxreiter Monika 
Published: March 2023

Abstract
Proteins form complex interactions in the cellular environment to carry out their functions. They exhibit a wide range of binding modes depending on the cellular conditions, which result in a variety of ordered or disordered assemblies. To help rationalise the binding behavior of proteins, the FuzPred server predicts their sequence-based binding modes without specifying their binding partners. The binding mode defines whether the bound state is formed through a disorder-to-order transition resulting in a well-defined conformation, or through a disorder-to-disorder transition where the binding partners remain conformationally heterogeneous. To account for the context-dependent nature of the binding modes, the FuzPred method also estimates the multiplicity of binding modes, the likelihood of sampling multiple binding modes. Protein regions with a high multiplicity of binding modes may serve as regulatory sites or hot-spots for structural transitions in the assembly. To facilitate the interpretation of the predictions, protein regions with different interaction behaviors can be visualised on protein structures generated by AlphaFold. The FuzPred web server (https://fuzpred.bio.unipd.it) thus offers insights into the structural and dynamical changes of proteins upon interactions and contributes to development of structure-function relationships under a variety of cellular conditions.
Cytomegalovirus Infections in Patients Treated With Immune Checkpoint Inhibitors for Solid Malignancies
Authors: Anastasopoulou Amalia , Samarkos Michael , Diamantopoulos Panagiotis , Vourlakou Christina , Ziogas Dimitrios C , Avramopoulos Pantelis , Kouzis Panagiotis , Haanen John , Gogas Helen 
Published: March 2023

AbstractCytomegalovirus (CMV) infection/disease has been repeatedly reported in patients treated with immune-checkpoint inhibitors (ICIs) and most commonly involves patients with relapsed/refractory (R/R) immune-related adverse events (irAEs). In the current study, we present a patient with melanoma who developed CMV gastritis during treatment with pembrolizumab in the absence of irAEs and without previous or current immunosuppression. Moreover, we review the literature regarding CMV infection/disease in patients treated with ICIs for solid malignancies. We present the currently available data on the pathogenesis, clinical characteristics, endoscopic findings, and histologic features and highlight the potential differences among cases complicating R/R irAEs versus those occurring in patients who are immunosuppression naive. Finally, we discuss the currently available data regarding potential useful diagnostic tools as well as the management of these patients.
Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
Authors: Chen Xuemin , Ciric Caroline , Gibson Theda , Anderson Larry J , Anderson Evan J , Rostad Christina A 
Published: March 2023

AbstractIn this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which gradually waned over 6 months, particularly against severe acute respiratory syndrome coronavirus 2 variants. These data support the indication for a subsequent booster vaccination.