bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of N6-methyladenosine methylation-related gene signature for predicting the prognosis of hepatocellular carcinoma patients
Authors: Zheng Xinyu , Zhang Yingyue , Wang Yun , He Zijing , Zhang Qiang , Ren Dapeng , Yan Xiao , Yuan Xiao 
Published: March 2023

Background and aimsHepatocellular carcinoma (HCC) is a common cause of cancer-related death in humans. Increasing evidence indicates that an imbalance in N6-methyladenosine (m6A) methylation is linked to the occurrence and development of cancer. We then developed a prognostic model as an independent risk factor with which predict the prognosis of HCC.MethodsWe obtained the gene expression and clinical data of HCC patients from the TCGA databases. The prognostic value of m6A methylation-related genes in patients who had HCC were subjected to comprehensive bioinformatics analysis. We use RiskScore=∑i=1nCoefi×Xi to construct the risk scoring formula. We collected pathological specimens from 68 patients who had HCC, and conducted immunohistochemical staining experiments on the specimens.ResultsThere was a significant correlation between candidate m6A methylation-related genes (YTHDF2, METTL14 and ZC3H13) overall survival of HCC patients. Among the 68 HCC patient specimens that underwent immunohistochemical staining, all cancer tissues were positive for METTL14, YTHDF2, and ZC3H13 staining in contrast to the adjacent tissues. We conducted a Kaplan-Meier survival analysis. The results showed that patients who had low METTL14 expression had a longer survival time than those of patients who had high METTL14 expression. Also, patients with low YTHDF2 expression had a longer survival time than patients with high YTHDF2 expression. Finally, patients with high ZC3H13 expression lived longer than those with low ZC3H13 expression. This result is consistent with the bioinformatics analysis conclusion above.ConclusionsGenerally, the prognostic model that was based on m6A methylation-related genes in this study can effectively predict the prognosis of HCC patients.
Age-Related changes in the morphological features of medial column of the proximal humerus in the Chinese population
Authors: Chang Zuhao , Zhu Zhengguo , Zhang Wei , Chen Hua , Liu Yujie , Tang Peifu 
Published: March 2023

BackgroundAge-related changes in the medial column (MC) of the proximal humerus have a major impact on fracture management; however, the changes in the morphological features remain unclear. This study aimed to investigate the age-related changes in the morphological features of MC and present the morphological grading.MethodsOne hundred computed tomography (CT) images of the proximal humerus of 100 individuals (19–95 years) were retrospectively obtained. The individuals were categorized into five age groups to quantify the differences among different ages; the youngest group (18–44 years) served as the baseline group. Parameters of the morphological features were measured on CT images with multiplanar reconstruction based on an explicit definition of MC, including length, thickness, width, oblique thickness (DSM), humeral head diameter (DHM), and ratio (RSM) of DSM to DHM. The morphological grading of MC was presented based on the value of RSM deviating different standard deviations (SD) from the mean value in the baseline group.ResultsSignificant negative correlations were observed between age and the morphological parameters of MC (r ranged from −0.875 to −0.926; all P &lt; 0.05), excluding DHM (r = 0.081, P = 0.422). Significant differences in the values of morphological feature parameters were detected among the five age groups (all P &lt; 0.001). The highest mean values of morphological feature parameters were observed in the youngest group (18–44 years), which decreased gradually with increasing age until the lowest mean values were observed in the oldest group (≥90 years) (all P &lt; 0.05). The morphological features of MC were categorized into three grades based on the value of RSM deviating 1.5 SD or 3 SD from the mean value in the baseline group.ConclusionOur study shows that the parameter values of morphological features of MC decreased with increasing age. The morphological features of MC could be categorized into three grades. Our findings may provide a more comprehensive insight into age-related changes in the morphological features of MC that facilitate risk stratification and optimize the management of proximal humeral fractures.
Association Between Multiple Chronic Conditions and Depressive Symptoms Among Older Adults in China: Evidence From the China Health and Retirement Longitudinal Study (CHARLS)
Authors: Liu Haixia , Zhou Zhongliang , Fan Xiaojing , Shen Chi , Ma Yang , Sun Hongwei , Xu Zhaoyang 
Published: March 2023

Objectives: The purpose of this study was to explore the association between multiple chronic conditions (MCCs) and depressive symptoms among older adults in China.Methods: We used the fourth round of data from the China Health and Retirement Longitudinal Study, and included 9789 older adults aged 60 years old and above.Results: Compared with the older adults without chronic disease, older adults with MCCs and those with one chronic disease had a high risk of depression (MCCs: OR-adjusted: 1.55, 95% CI: 1.37 to 1.75; one chronic disease: OR-adjusted: 1.20, 95% CI: 1.05–1.37). In urban areas, the prevalence among older adults with MCCs was 2.01 times higher than that among older adults without chronic disease (OR-adjusted: 2.01, 95% CI: 1.56–2.60), while it was 1.44 times higher in rural areas (OR-adjusted:1.44, 95% CI: 1.25–1.65). Self-reported health, duration of sleep, social activities, and type of medical insurance were the influencing factors of depressive symptoms in older adults.Conclusion: This study contributed to enriching the research on the relationship between MCCs and depressive symptoms in older adults in China.
Photocatalytic Properties of ZnO:Al/MAPbI3/Fe2O3 Heterostructure: First-Principles Calculations
Authors: Al-Shami Ahmed , Sibari Anass , Mansouri Zouhir , El Kassaoui Majid , El Kenz Abdallah , Benyoussef Abdelilah , Loulidi Mohammed , Jouiad Mustapha , El Moutaouakil Amine , Mounkachi Omar 
Published: March 2023

We report on theoretical investigations of a methylammonium lead halide perovskite system loaded with iron oxide and aluminum zinc oxide (ZnO:Al/MAPbI3/Fe2O3) as a potential photocatalyst. When excited with visible light, this heterostructure is demonstrated to achieve a high hydrogen production yield via a z-scheme photocatalysis mechanism. The Fe2O3: MAPbI3 heterojunction plays the role of an electron donor, favoring the hydrogen evolution reaction (HER), and the ZnO:Al compound acts as a shield against ions, preventing the surface degradation of MAPbI3 during the reaction, hence improving the charge transfer in the electrolyte. Moreover, our findings indicate that the ZnO:Al/MAPbI3 heterostructure effectively enhances electrons/holes separation and reduces their recombination, which drastically improves the photocatalytic activity. Based on our calculations, our heterostructure yields a high hydrogen production rate, estimated to be 265.05 μmol/g and 362.99 μmol/g, respectively, for a neutral pH and an acidic pH of 5. These theoretical yield values are very promising and provide interesting inputs for the development of stable halide perovskites known for their superlative photocatalytic properties.
Ecological Factors Associated with the Distribution of Bemisia tabaci Cryptic Species and Their Facultative Endosymbionts
Authors: Li Hongran , Jiang Zhihui , Zhou Jincheng , Liu Xin , Zhang Youjun , Chu Dong 
Published: March 2023

The sweetpotato whitefly, Bemisia tabaci species complex, comprises at least 44 morphologically indistinguishable cryptic species, whose endosymbiont infection patterns often varied at the spatial and temporal dimension. However, the effects of ecological factors (e.g., climatic or geographical factors) on the distribution of whitefly and the infection frequencies of their endosymbionts have not been fully elucidated. We, here, analyzed the associations between ecological factors and the distribution of whitefly and their three facultative endosymbionts (Candidatus Cardinium hertigii, Candidatus Hamiltonella defensa, and Rickettsia sp.) by screening 665 individuals collected from 29 geographical localities across China. The study identified eight B. tabaci species via mitochondrial cytochrome oxidase I (mtCOI) gene sequence alignment: two invasive species, MED (66.9%) and MEAM1 (12.2%), and six native cryptic species (20.9%), which differed in distribution patterns, ecological niches, and high suitability areas. The infection frequencies of the three endosymbionts in different cryptic species were distinct and multiple infections were relatively common in B. tabaci MED populations. Furthermore, the annual mean temperature positively affected Cardinium sp. and Rickettsia sp. infection frequencies in B. tabaci MED but negatively affected the quantitative distribution of B. tabaci MED, which indicates that Cardinium sp. and Rickettsia sp. maybe play a crucial role in the thermotolerance of B. tabaci MED, although the host whitefly per se exhibits no resistance to high temperature. Our findings revealed the complex effects of ecological factors on the expansion of the invasive whitefly.
Modeling Soil CO2 Efflux in a Subtropical Forest by Combining Fused Remote Sensing Images with Linear Mixed Effect Models
Authors: Ablat Xarapat , Huang Chong , Tang Guoping , Erkin Nurmemet , Sawut Rukeya 
Published: March 2023

Monitoring tropical and subtropical forest soil CO2 emission efflux (FSCO2) is crucial for understanding the global carbon cycle and terrestrial ecosystem respiration. In this study, we addressed the challenge of low spatiotemporal resolution in FSCO2 monitoring by combining data fusion and model methods to improve the accuracy of quantitative inversion. We used time series Landsat 8 LST and MODIS LST fusion images and a linear mixed effect model to estimate FSCO2 at watershed scale. Our results show that modeling without random factors, and the use of Fusion LST as the fixed predictor, resulted in 47% (marginal R2 = 0.47) of FSCO2 variability in the Monthly random effect model, while it only accounted for 19% of FSCO2 variability in the Daily random effect model and 7% in the Seasonally random effect model. However, the inclusion of random effects in the model’s parameterization improved the performance of both models. The Monthly random effect model that performed optimally had an explanation rate of 55.3% (conditional R2 = 0.55 and t value > 1.9) for FSCO2 variability and yielded the smallest deviation from observed FSCO2. Our study highlights the importance of incorporating random effects and using Fusion LST as a fixed predictor to improve the accuracy of FSCO2 monitoring in tropical and subtropical forests.
Improving Seaport Wharf Maintenance and Safety with Structural Health Monitoring System in High Salt and Humidity Environments
Authors: Li Yuesong , Zhu Pengrui , Zhang Gan , Yu Yang 
Published: March 2023

Due to the harsh working conditions, the durability of the seaport wharf structure is poor compared with similar hydraulic structures. According to the structural characteristics of coastal port wharf and the particularity of a high salt and high humidity environment, the stress features of the coastal wharf structure are analyzed, and the health inspection indicators of the wharf structure are proposed. A fiber grating sensor-based structural health monitoring system for coastal high-pile piers is established. A corresponding system for detecting structural health is designed according to the standard structural section of the wharf’s front platform. The corresponding monitoring implementation scheme, sensor selection, and performance parameters are proposed. Finally, the realization technology and related indicators of data acquisition and transmission subsystem are given. The experimental results indicate that the waveform of the structural response to the wave load has a consistent sine wave pattern with the actual wave load. The maximum strain of the berthing pier appears at 4.35 m and 6.14 m, and the elevations reach 4.66 με and 5.31 με, respectively. The strain at other positions also has an obvious change trend. The experimental results provide some help for the research of the wharf health monitoring system.
Síndrome de Sheehan, um relato de caso
Authors: Leal Renata Mateus , De Oliveira Francielle Temer , Dantas Renata Santana , Leite Mariana Cardoso , Cruz Amanda Raquel Costa , Oliveira Hektor Silva , Bomfim Natália Sampaio Carvalho , Nascimento Brenno Victor dos Santos 
Published: March 2023

A síndrome de Sheehan refere-se ao hipopituitarismo secundário a necrose hipofisária devido a hipotensão grave precipitada por hemorragia pós parto. Sua apresentação pode ser de forma aguda ou crônica, sendo esta última de caráter insidioso, com sintomas inespecíficos, levando, frequentemente, a um diagnóstico tardio. Sua investigação requer uma história obstétrica compatível com hemorragia pós parto, evoluindo com agalactia e amenorréia, associada a evidência de insuficiência dos hormônios hipofisários de grau variável e exame de imagem evidenciando a sela turca total ou parcialmente vazia. O tratamento consiste na reposição hormonal, importante para melhora da qualidade de vida e redução da morbimortalidade das pacientes. Dessa forma, este trabalho tem como objetivo relatar um caso de síndrome de Sheehan e informar sobre esta condição médica que ainda é subdiagnosticada.
Catálogo comentado das espécies de abelhas do gênero Eulaema Lepeletier, 1841 (Hymenoptera: Apidae)
Authors: Oliveira Marcio L. de 
Published: March 2023

The taxonomic information on the species of Eulaema Lepeletier, 1841 is updated. Three of the species recently described by Moure — E. pallescens Moure, 2000, E. stenozona Moure, 2000 and E. helvola Moure, 2000 — are synonymized with E. meriana (Olivier, 1789), E. terminata (Smith, 1874) and E. seabrai Moure, 1960, respectively. Two species revalidated by Moure (2000), E. quadrifasciata (Friese, 1903) and E. niveofasciata (Friese, 1899), are considered synonyms of E. meriana (Olivier, 1789) and E. bombiformis (Packard, 1869), respectively. Besides, E. mimetica Moure, 1967 is considered a synonym of E. tenuifasciata (Friese, 1925). Additions to the catalogue by Moure (2000) include Eulaema sororia Dressler & Ospina-Torres (1997) and E. chocoana Ospina-Torres & Sandino-Franco (1997), which were not mentioned by Moure (opus cit.), and E. napensis Oliveira, 2006, E. parapolyzona Oliveira, 2006 and E. pseudocingulata Oliveira, 2006, described after the publication of his catalogue. Lectotypes of E. boliviensis Friese, 1898, E. bomboides (Friese, 1923), E. polyzona (Mocsary, 1897) and E. tenuifasciata (Friese, 1925) are designated. Comments on the known geographic distributions of the 25 regonized species and maps illustrating them are also presented.
Keywords: Neotropics, orchid-bees, taxonomy, geographic distribution, lectotype designation.
Translational Studies Using the MALT1 Inhibitor (S)-Mepazine to Induce Treg Fragility and Potentiate Immune Checkpoint Therapy in Cancer
Authors: Di Pilato Mauro , Gao Yun , Sun Yi , Fu Amina , Grass Carina , Seeholzer Thomas , Feederle Regina , Mazo Irina , Kazer Samuel W. , Litchfield Kevin , von Andrian Ulrich H. , Mempel Thorsten R. , Jenkins Russell W. , Krappmann Daniel , Keller Peter 
Published: March 2023

ABSTRACT

Introduction
Regulatory T cells (Tregs) play a critical role in the maintenance of immune homeostasis but also protect tumors from immune-mediated growth control or rejection and pose a significant barrier to effective immunotherapy. Inhibition of MALT1 paracaspase activity can selectively reprogram immune-suppressive Tregs in the tumor microenvironment to adopt a proinflammatory fragile state, which offers an opportunity to impede tumor growth and enhance the efficacy of immune checkpoint therapy (ICT).

Methods
We performed preclinical studies with the orally available allosteric MALT1 inhibitor (S)-mepazine as a single-agent and in combination with anti-programmed cell death protein 1 (PD-1) ICT to investigate its pharmacokinetic properties and antitumor effects in several murine tumor models as well as patient-derived organotypic tumor spheroids (PDOTS).

Results
(S)-mepazine demonstrated significant antitumor effects and was synergistic with anti-PD-1 therapy in vivo and ex vivo but did not affect circulating Treg frequencies in healthy rats at effective doses. Pharmacokinetic profiling revealed favorable drug accumulation in tumors to concentrations that effectively blocked MALT1 activity, potentially explaining preferential effects on tumor-infiltrating over systemic Tregs.

Conclusions
The MALT1 inhibitor (S)-mepazine showed single-agent anticancer activity and presents a promising opportunity for combination with PD-1 pathway-targeted ICT. Activity in syngeneic tumor models and human PDOTS was likely mediated by induction of tumor-associated Treg fragility. This translational study supports ongoing clinical investigations (ClinicalTrials.gov Identifier: NCT04859777) of MPT-0118, (S)-mepazine succinate, in patients with advanced or metastatic treatment-refractory solid tumors.
Healthcare Resource Utilization and Costs Among Patients With Gastroesophageal Reflux Disease, Barrett’s Esophagus, and Barrett’s Esophagus-Related Neoplasia in the United States
Authors: Sharma Prateek , Falk Gary W. , Bhor Menaka , Ozbay A. Burak , Latremouille-Viau Dominick , Guerin Annie , Shi Sherry , Elvekrog Margaret M. , Limburg Paul 
Published: March 2023

Background: Gastroesophageal reflux disease (GERD) is a risk factor for Barrett’s esophagus (BE) and BE-related neoplasia (BERN). Objectives: This study aimed to evaluate healthcare resource utilization (HRU) and costs associated with GERD, BE, and BERN in the United States. Methods: Adult patients with GERD, nondysplastic BE (NDBE), and BERN (including indefinite for dysplasia [IND], low-grade dysplasia [LGD], high-grade dysplasia [HGD] or esophageal adenocarcinoma [EAC]), were identified from a large US administrative claims database, the IBM Truven Health MarketScan® databases (Q1/2015-Q4/2019). Patients were categorized into the corresponding mutually exclusive EAC-risk/diagnosis cohorts based on the most advanced stage from GERD to EAC using diagnosis codes in medical claims. Disease-related HRU and costs (2020 USD) were calculated for each cohort. Results: Patients were categorized into the following EAC-risk/diagnosis cohorts: 3 310 385 into GERD, 172 481 into NDBE, 11 516 into IND, 4332 into LGD, 1549 into HGD, and 11 676 into EAC. Disease-related annual mean number of inpatient admissions, office visits, and emergency department visits by cohort were 0.09, 1.45, and 0.19 for GERD; 0.08, 1.55, and 0.10 for NDBE; 0.10, 1.92, and 0.13 for IND; 0.09, 2.05, and 0.10 for LGD; 0.12, 2.16, and 0.14 for HGD; and 1.43, 6.27, and 0.87 for EAC. Disease-related annual mean total healthcare costs by cohort were $6955 for GERD, $8755 for NDBE, $9675 for IND, $12 241 for LGD, $24 239 for HGD, and $146 319 for EAC. Discussion: Patients with GERD, BE, and BERN had important HRU and costs, including inpatient admissions and office visits. As patients progressed to more advanced stages, there was substantially higher disease-related resource utilization, with associated costs being 16 times higher in patients with EAC than those with NDBE. Conclusions: Findings suggest the need for early identification of high-risk individuals prior to progression to EAC to potentially improve clinical and economic outcomes in this population.
Determinantes da assistência materno-infantil segura a luz de evidências cientí­ficas: uma revisão integrativa
Authors: Padovani Camila , Pomin Frutos da Silva Juan , Silva Dantas Letí­cia , Karina Rissardo Leidyani , Benatti Antunes Marcos , Marisa Pelloso Sandra 
Published: March 2023

Objetiva-se identificar fatores que promovam falhas no cuidado obstétrico e comprometam a segurança da gestante edo bebê. Trata-se de uma revisão integrativa, realizada nas bases de dados: MEDLINE, LILACS, BDENF, no perí­odo de janeiro de 2006 a janeiro de 2016 com uso das palavras-chaves: "enfermagem", "segurança do paciente", "obstetrí­cia" e "maternidade". Foram selecionados oito estudos elegí­veis. A análise dos artigos resultou nas categorias: Comunicação interpessoal e trabalho em equipe no cuidado obstétrico e práticas e condutas que afetam a assistência segura í saúde materna e perinatal. Conclui-se que para um cuidado seguro, é necessário cuidados respaldados pelas técnicas fundamentadas na literatura em conjunto ao comprometimento profissional e visão holí­stica do paciente, para que possa oferecer uma assistência materno-infantil segura.
Family Support and The Role of Health Professionals on Parent’s Perspectives of Covid-19 Vaccination in Child
Authors: Nurdiyan Ayu , Susanti Evi 
Published: March 2023

Background: The administration of Covid-19 immunization is one of the measures taken to prevent Covid-19 infectious diseases among vulnerable groups, such as children aged 6 to 11 years. However, the majority of parents continue to have a poor opinion of the safety of the Covid-19 vaccine and its side effects, since just 5.7% of parents of 564,833 children in West Sumatra allow their children to get vaccinated.
Purpose: This study aimed to investigate the determinants of parents’ perception towards vaccinating their children against COVID-19.
Methods: This study employed a quantitative methodology and a Cross Sectional design. This research was conducted at an elementary school in Bukittinggi. The study population consisted of 466 children. In this study, 100 respondents were consecutively selected as samples. The tool employed was a valid and reliable questionnaire, and the data were analyzed using a chi-square test with a significance level of 0.05.
Results: the results of the statistical test of bivariate analysis stated that there was a relationship between family support and perspective, p Value 0.05 (< 0.05), and there was no relationship between the role of health workers and perspective p Value 0.318 (> 0.05).
Conclusion: it is important to increase the positive perspective of parents regarding vaccination, this can be done through health promotion by using various media so that not only parents get but also increase the perception of family support.