bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrieving the Stability and Practical Performance of Activation‐Unstable Mesoporous Zr(IV)‐MOF for Highly Efficient Self‐Calibrating Acidity Sensing
Authors: Lang Feifan , Zhang Lulu , Li Yang , Xi Xiao‐Juan , Pang Jiandong , Zheng Wenjun , Zhou Hong‐Cai , Bu Xian‐He 
Published: January 2025

AbstractThe practical applications of activation‐unstable mesoporous metal‐organic frameworks (MOFs) are often constrained by their structural instability. However, enhancing their stability could unlock valuable functionalities. Herein, we stabilized the otherwise unstable, post‐activated structure of a novel mesoporous Zr(IV)‐MOF, NKM‐809, which constructed from a pyridine‐containing amphiprotic linker (PPTB). We applied two strategies: mixed‐linker synthesis and linker installation. In the mixed‐linker approach, we incorporated an auxiliary linker, TPTB, which resembles PPTB, during synthesis to improve the framework's stability. In the linker installation approach, we introduced a ditopic carboxylate linker (BPDC) into the coordination‐unsaturated sites of NKM‐809. These strategies produced stabilized derivatives, named NKM‐808.X (X=χPPTB) and NKM‐809‐BPDC, which exhibit pH‐responsive dual‐wavelength fluorescence at distinct emission wavelengths. Remarkably, these emissions shift oppositely upon protonation and dissociation, distinguishing them as highly sensitive, self‐calibrating acidity sensors. In NKM‐809‐BPDC, an additional quenching of the linker‐emission (419 nm) minimizes inherent interference, enabling integrated quality and lifespan self‐monitoring. Theoretical calculations identified transitions between (n, π*) and (π, π*) emission states during the sensing process and highlighted the role of a stable mesoporous network in achieving stronger protonation response. These findings showcase the potential of stabilized mesoporous MOFs for practical applications, alongside valuable insights into strategies for optimizing such materials.
Two Ferrocene‐Modified Copper(I) Complexes for the Synergistic Enhancement of Chemodynamic Therapy
Authors: Peng Rui , Zhong Jing‐Jing , Yang Daohan , Hong Zhaoguo , Bian He‐Dong , Huang Fu‐Ping 
Published: January 2025

ABSTRACTIn recent years, some Cu‐based complexes and nanomaterials that can better adapt to tumour microenvironments and produce better chemodynamic therapeutic effects have been synthesised. Ferrocene and its derivatives have garnered increasing attention as a therapeutic option in chemodynamic therapy owing to their excellent catalytic activity. Herein, two ferrocene‐modified Cu(I) complexes, Fc‐AD‐Cu and Fc‐IH‐Cu, were synthesised with atomically precise structures. Both exhibit good Fenton/Fenton‐like activity, inducing the generation of reactive oxygen species in Hep‐G2 cells and improving chemodynamic therapeutic efficiency.
Novel Dehydroabietylamine C‐Ring Schiff Base Derivatives: Synthesis, Antiproliferative activity, DNA binding and Molecular docking
Authors: Li Lin , Lu Wen , Xue Huayu , Yang Shilong , Zhou Mengyi , Xu Li 
Published: January 2025

AbstractA series of Dehydroabietylamine (DHAA) C‐ring Schiff derivatives, L3‐L20, were synthesized and their in vitro cytotoxic activity against the human tumor cell lines cervix HeLa, breast MCF‐7, lung A549, liver HepG2, and the nonmalignant cell line umbilical vein HUVEC was investigated. Most of the compounds showed varying degrees of anticancer activity against HeLa cell lines while demonstrating lower toxicity to normal HUVEC cells compared to DHAA and doxorubicin (DOX), especially compound L19, which not only enhanced the anticancer activity of DHAA, but also significantly reduced the toxicity to normal cells, achieving a selectivity index (SI) 118 times higher than that of DHAA and 245 times higher than that of DOX. In addition, Compound L19 induced apoptosis in HeLa cells in a dose‐dependent manner, suppressed the expression of the anti‐apoptotic protein Bcl‐2, and arrested the cell cycle at the S phase. Spectroscopic experiments and molecular docking results showed that there was a strong interaction between the compounds and DNA. All these results indicate that the introduction of Schiff base structure on the C‐ring of DHAA is an effective strategy for enhancing its selectivity, providing new insights for the design of DHAA‐based anticancer compounds.
Brønsted Acid‐Catalyzed Regioselective Coupling between Azoles and Arylcyclobutenes
Authors: Jing Chunxiu , Wang Juanjuan , Chang Jie , He Yi , Zheng Zhaojing , Wei Hao 
Published: January 2025

AbstractHerein, we describe a protocol for Brønsted acid‐catalyzed regioselective coupling of azoles such as pyrazoles, 1,2,3‐triazole, 1,3,4‐triazole, benzotriazole, indazole and tetrazole, to cyclobutenes. These azoles could be directly coupled with various arylcyclobutenes with high site‐selectivity, offering a distinct entry to more functionalized cyclobutanes. The usage of inexpensive TsOH ⋅ H2O catalyst, broad substrate scope, and open‐air conditions make this protocol practically viable. This study not only contributes a feasible tool for selective functionalization of cyclobutenes, but also provides a strategy to introduce cyclobutane moieties into complex molecules.
Recommendations for the Safe Application of Temporal Interference Stimulation in the Human Brain Part II: Biophysics, Dosimetry, and Safety Recommendations
Authors: Cassarà Antonino M. , Newton Taylor H. , Zhuang Katie , Regel Sabine J. , Achermann Peter , Pascual‐Leone Alvaro , Kuster Niels , Neufeld Esra 
Published: January 2025

ABSTRACTTemporal interference stimulation (TIS) is a new form of transcranial electrical stimulation (tES) that has been proposed as a method for targeted, noninvasive stimulation of deep brain structures. While TIS holds promise for a variety of clinical and nonclinical applications, little data is yet available regarding its effects in humans and its mechanisms of action. To inform the design and safe conduct of experiments involving TIS, researchers require quantitative guidance regarding safe exposure limits and other safety considerations. To this end, we undertook a two‐part effort to determine frequency‐dependent thresholds for applied currents below which TIS is unlikely to pose risk to humans in terms of heating or unwanted stimulation. In Part II of this effort, described here, we draw on a previously compiled list (see Part I) of adverse effects (AEs) reported for transcranial direct/alternating current stimulation (tDCS/ACS), deep brain stimulation (DBS), and TIS to determine biophysics‐informed exposure metrics for assessing safety. Using an in silico approach, we conduct multiphysics simulations of various tACS, DBS, and TIS exposure scenarios in an anatomically detailed head and brain model. By matching the stimulation in terms of the identified exposure metrics, we infer frequency‐dependent TIS parameters that produce exposure conditions equivalent to those known to be safe for tACS and DBS. Based on the results of our simulations and existing knowledge regarding tES and DBS safety, we propose frequency‐dependent thresholds below which TIS voltages and currents are unlikely to pose a risk to humans. Safety‐related data from ongoing and future human studies are required to verify and refine the thresholds proposed here.
The Development of a Reverberation Chamber for the Assessment of Biological Effects of Electromagnetic Energy Absorption in Mice
Authors: Iskra Steve , McIntosh Robert L. , McKenzie Raymond J. , Frankland John V. , Deng Chao , Sylvester Emma , Wood Andrew W. , Croft Rodney J. 
Published: January 2025

ABSTRACTIn this paper, we present the design, RF‐EMF performance, and a comprehensive uncertainty analysis of the reverberation chamber (RC) exposure systems that have been developed for the use of researchers at the University of Wollongong Bioelectromagnetics Laboratory, Australia, for the purpose of investigating the biological effects of RF‐EMF in rodents. Initial studies, at 1950 MHz, have focused on investigating thermophysiological effects of RF exposure, and replication studies related to RF‐EMF exposure and progression of Alzheimer's disease (AD) in mice predisposed to AD. The RC exposure system was chosen as it allows relatively unconstrained movement of animals during exposures which can have the beneficial effect of minimizing stress‐related, non‐RF‐induced biological and behavioral changes in the animals. The performance of the RCs was evaluated in terms of the uniformity of the Whole‐Body Average‐Specific Absorption Rate (WBA‐SAR) in mice for a given RF input power level. The expanded uncertainty in WBA‐SAR estimates was found to be 3.89 dB. Validation of WBA‐SAR estimates based on a selected number of temperature measurements in phantom mice found that the maximum ratio of the temperature‐derived WBA‐SAR to the computed WBA‐SAR was 1.1 dB, suggesting that actual WBA‐SAR is likely to be well within the expanded uncertainties.
Biological function and mechanism of NAT10 in cancer
Authors: Han Yufeng , Zhang Xinxin , Miao Lei , Lin Huiran , Zhuo Zhenjian , He Jing , Fu Wen 
Published: January 2025

AbstractN‐acetyltransferase 10 (NAT10) is a nucleolar acetyltransferase with an acetylation catalytic function and can bind various protein and RNA molecules. As the N4‐acetylcytidine (ac4C) “writer” enzyme, NAT10 is reportedly involved in a variety of physiological and pathological activities. Currently, the NAT10‐related molecular mechanisms in various cancers are not fully understood. In this review, we first describe the cellular localization of NAT10 and then summarize its numerous biological functions. NAT10 is involved in various biological processes by mediating the acetylation of different proteins and RNAs. These biological functions are also associated with cancer progression and patient prognosis. We also review the mechanisms by which NAT10 plays roles in various cancer types. NAT10 can affect tumor cell proliferation, metastasis, and stress tolerance through its acetyltransferase properties. Further research into NAT10 functions and expression regulation in tumors will help explore its future potential in cancer diagnosis, treatment, and prognosis.
Cu(I)‐Anchored Amine‐Rich Covalent‐Organic Polymer for Sustainable Utilization of CO2 in the Synthesis of Valuable Chemicals and C─C Bond Formation Reactions
Authors: Rana Abhijeet , Mukherjee Srijan , Sundari Kalimuthu Abirami , Dhakshinamoorthy Amarajothi , Biswas Shyam 
Published: January 2025

AbstractSelective chemical fixation of carbon dioxide (CO₂) offers a promising approach to mitigate rising atmospheric CO₂ levels while facilitating the synthesis of valuable commodity chemicals, thereby supporting the circular economy. The cycloaddition of CO₂ to form α‐alkylidene cyclic carbonates is particularly attractive due to its utilization of CO₂, a low‐cost C1 feedstock, in a reaction with 100% atom economy. In this study, we have developed an amine‐functionalized, nitrogen‐rich covalent organic polymer (COP), SNW‐1@NH₂, which strongly supports the grafting of Cu(I) ions within its porous framework. The synergistic interaction between SNW‐1@NH₂ and Cu(I) enhances the catalytic activity for the CO₂ cycloaddition with propargylic alcohol, resulting in the formation of α‐alkylidene cyclic carbonates at room temperature without the need for precious metal catalysts. Notably, the catalyst exhibits a broad substrate scope with high recyclability and maintains its structural integrity and catalytic performance. Additionally, the SNW‐1@NH₂ was successfully applied in the catalytic Knoevenagel condensation of benzaldehyde with cyanoacetamide, demonstrating a broad substrate scope, excellent recyclability, and stability. Mechanistic studies were performed to elucidate the reaction pathways for both catalytic processes. This work underscores the potential of nitrogen‐rich porous materials in addressing the critical environmental challenges and expanding catalytic applications.
PROTOCOL: Non‐criminal justice interventions for countering cognitive and behavioural radicalisation amongst children and adolescents: A systematic review of effectiveness and implementation
Authors: Lewis James , Marsden Sarah , Stefaniak Anna , Hewitt James 
Published: January 2025

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows. (1) Examine whether secondary and tertiary interventions delivered outside of the criminal justice system are effective at countering the cognitive and behavioural radicalisation of children and adolescents by synthesising evidence relating to relevant primary and secondary outcomes of effectiveness. (2) Examine whether secondary and tertiary interventions delivered outside of the criminal justice system are being implemented as intended by synthesising evidence that captures how interventions are implemented, considering whether they are implemented as expected or in ways that align with their underlying logic. (3) Identify those implementation factors (facilitators and barriers) and moderators that impact how interventions working with children and adolescents are delivered.
Health Care Resource Utilization With Dronedarone Versus Sotalol Following Catheter Ablation in Adults With Atrial Fibrillation
Authors: Zeitler Emily P. , Stein Dara , Preblick Ron , Kabadi Shaum M. , McKindley David S. , Rashkin Jason , Huse Samuel , Stamas Nicole , Kim Michael H. 
Published: January 2025

ABSTRACTBackgroundClinical trials support dronedarone use for atrial fibrillation (AF) following catheter ablation (CA); however, comparative data on health care resource utilization (HCRU) with other antiarrhythmic drugs are lacking.MethodsRetrospective analysis of Merative MarketScan databases (January 01, 2012−March 31, 2020) comparatively assessed HCRU in US adults with AF who received dronedarone or sotalol post‐CA. Patients with ≥ 12‐months' pre‐CA data were followed from post‐CA index treatment to disenrollment, death, or study end. Sotalol‐treated patients were propensity score‐matched (1:1) with dronedarone‐treated patients. Events/100 patient‐years (PY) were analyzed by univariate generalized‐linear model with Poisson distribution. Cumulative incidence was analyzed over 12 months by Kaplan–Meier methods. Subgroup analyses were conducted by sex and patients new to dronedarone or sotalol during 12 months pre‐CA.ResultsDronedarone and sotalol cohorts were successfully matched (n = 1600 each). Prevalence/100‐PY for all‐cause, cardiovascular (CV)‐related, and atrial tachyarrhythmia (ATA)/AF–related HCRU was lower in dronedarone versus sotalol cohort (all p < 0.05). Cumulative incidence for all‐cause, CV‐related, ATA/AF‐related hospitalizations, and pacemaker implantation was lower in dronedarone versus sotalol cohort (all p < 0.05). Incidence of all‐cause and CV‐related hospitalizations was lower in dronedarone versus sotalol cohorts in females (n = 460) and males (n = 1115) (all p < 0.05) after rematching. Incidence of ATA/AF‐related hospitalization was lower in males versus females receiving dronedarone. For patients new to dronedarone or sotalol (n = 549), HCRU results were generally consistent with primary analyses.ConclusionPost‐CA dronedarone, versus sotalol, lowered CV‐related HCRU in all‐comers with AF and in sex subgroups. Findings may contribute to clinical decision making post‐CA in patients with AF.
Gut microbial alteration in chronic spontaneous urticaria unresponsive to second generation antihistamines and its correlation with disease characteristics‐ a cross‐sectional case‐control study
Authors: Podder Indrashis , Pesqué David , Carrón Nerea , González Torres Pedro Iñaki , Pujol Ramon M. , Giménez‐Arnau Ana M. 
Published: January 2025

AbstractBackgroundGut microbial involvement has been speculated in chronic spontaneous urticaria (CSU). The aim of the study was to compare the gut microbiome composition and diversity in CSU patients uncontrolled with second‐generation antihistamines (sgAHs) and healthy individuals, as well as to explore any association between gut microbiome and disease characteristics.MethodsA cross‐sectional case‐control study including 20 CSU patients unresponsive to standard doses of sgAHs, and 15 age‐and‐sex matched healthy controls was conducted. Clinico‐demographic profile, laboratory investigations and stool analysis were conducted in all study participants. 16S RNA gene sequencing and DNA isolation was performed for all stool samples, followed by bioinformatic analysis.ResultsThe CSU patients (mean age 39.5 ± 9.3, M:F 1:4) and healthy controls (mean age 35 ± 13, M:F 1:2) were statistically comparable. The median (IQR) duration of CSU was 42 months (7–81). Concomitant angioedema and concomitant symptomatic dermographism were present in 30% and 20% CSU patients, respectively. At inclusion, 60% patients were receiving add‐on omalizumab, while the remaining 40% were on up‐dosed sgAHs. Stool microbial analysis revealed increased diversity and higher microbial richness in CSU patients compared with healthy individuals. CSU patients showed reduced load of short‐chain fatty acid (SCFA) producing microbiota and increased load of opportunistic pathogens. The Firmicutes/Bacteroides (F/B) ratio was higher in CSU patients. Among CSU patients, higher Bacteroides and reduced Firmicutes count were associated with higher disease activity and poor control; however, there was no link with the type of therapy.ConclusionGut microbial dysbiosis is seen in CSU and is linked with disease control.
Early neurodevelopmental follow‐up results from the NEOLEV2 cohort
Authors: Sharpe Cynthia , Reiner Gail E. , Reed Peter W. , Joe Priscilla , Wilson Francessa , Davis Suzanne L. , Lee Lilly , Wang Sonya , Gold Jeff , Haas Richard H. 
Published: January 2025

AbstractAimThe aim of this study was to evaluate predictors of neurodevelopmental outcome following hypoxic‐ischemic encephalopathy (HIE) and neonatal seizures in the randomized controlled trial cohort from the NEOLEV2 study.MethodSeizure burden, randomized levetiracetam versus phenobarbital antiseizure medication, and duration of breastfeeding were studied as predictors of neurodevelopmental outcome.ResultsOutcome could be assessed in 115 patients with HIE and/or seizures; 89 patients with HIE (50% of 178 patients with HIE in the original cohort), and 60 patients with seizures (63% of 96 patients with seizures in the original cohort), and including 34 patients who had both HIE and seizures. A strong association between seizure burden and outcome was shown. However, the association was not statistically significant after correction for known predictors of outcome: magnetic resonance imaging severity of injury score, Sarnat score, and hypothermia treatment. This study was underpowered to assess for effect of randomized antiseizure medication or duration of breastfeeding on neurodevelopmental outcome; however, no large trends were seen.InterpretationThis study adds to the debate as to whether neonatal seizures have an independent detrimental effect on neurodevelopmental outcome. Larger studies with longer neurodevelopmental follow‐up are needed to investigate these questions.
Application of Artificial Intelligence Advances in Athletics Industry: A Review
Authors: Du Tao , Bi Nan 
Published: January 2025

ABSTRACTWith the rapid development of Artificial Intelligence (AI) technology, the athletics field is undergoing profound changes. This transformation is reflected not only in the ways of training and competition but also in the overall enhancement of athletes' performance and the efficiency of event management. The introduction of AI has made data analysis feasible, enabling coaches and athletes to gain deeper insights and make more informed decisions. This paper reviews the current applications of AI in the athletics domain and its enhancement of athlete performance and competitive strategies, focusing on the practical applications of AI in event management, performance analysis, injury detection, and personalized training. Furthermore, AI systems support coaches in intelligent analysis by integrating historical data with real‐time data, thereby improving the efficiency of tactical decision‐making. However, despite the significant achievements in AI applications, a series of challenges remain, including the lack of high‐quality datasets, insufficient model interpretability, and ethical and privacy issues. In light of these challenges, we also propose viewpoints on future development directions aimed at promoting the intelligent transformation of the athletics industry.
Tunable Focusing Liquid Crystal Lenses: The Challenges and the Opportunities
Authors: Hirankittiwong Pemika , Laeim Huddad , Molahalli Vandana , Alodhayb Abdullah , Chattham Nattaporn , Hegde Gurumurthy 
Published: January 2025

AbstractThe utilization of liquid crystals (LC) as materials has enabled the enlargement of lenses with the potential to alter their focus. Tunable LC lenses with adjustable focus are essential for optical imaging, sensing, and detection devices. This technology offers many benefits, such as the ability to adjust focus, operate with low power, and be easily made. Its compact structure and stability are also advantages. Adding polymer additives to pure LC systems enhances their capabilities and provides more flexibility and functionality. This review explores ways to enhance the performance of tunable LC lenses, including image quality, speed, optical power, and device fabrication. Especially, enhancements include a switchable focus range, wider viewing angles, and a flexible lens. The challenges in fabricating and controlling LC methods have significant implications for many potential applications. The discovery of new LC materials and lens designs will further highlight these implications.
Using Industrial Mining Solid Waste through Conversion to Phase‐Change Materials for Thermal Energy Storage
Authors: Jiang Jiaping , Cao Yitong , Li Guo , Geng Long , Zhang Xiao , Zhao Jiateng , Liu Changhui 
Published: January 2025

AbstractThe mining industry produces a large amount of industrial solid waste every year. Among them, fly ash (FA), slag and tailings are the three main solid wastes, which can cause soil pollution, air pollution, water pollution and serious threat to human health if not handled properly. At present, the treatment methods of industrial solid waste mainly include direct landfill, recovery of high‐value components, production of construction materials, etc. These methods not only waste land resources, but also have a limited scope of application. Mining and metallurgical industrial solid wastes are generally characterized by high porosity, certain mechanical strength, and high yield, which can be used as a porous matrix to support phase change materials (PCMs) after modification treatment, thus solving the problem of easy leakage of PCMs. At present, there is no overview of mining industry solid waste in PCM applications. This paper provides a detailed review of the research progress of FA, slag and tailings in the field of phase change thermal storage materials in recent years, which provides useful ideas for further research on the comprehensive utilization of solid wastes in the mining and metallurgical industry and the reduction of their pollution of the environment.