bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational analysis of coiled tubing concerns during oil well intervention in the upper Assam basin, India
Authors: Neog Dhrubajyoti , Sarmah Ankur , Baruah Mohammad Irfan Sunny 
Published: January 2023

AbstractCoil tubing (CT) is widely regarded as one of the most effective servicing tools for dealing with a variety of oil and gas production issues, and it is also commonly used for oil well workover operations in India's upper Assam basin. The current work considers QT 800 to be the CT material used for actual oil well operations. With reference to actual operations carried out in some of the oil wells in the upper Assam basin, the current research analyses the limitations of CTs (QT 800, QT 900, and QT 1000) based on developing limit curves that can depict the operating limit and infer CT failure probability. This study also includes fatigue analysis to determine the likelihood of damage from hot oil circulation, water injection, and nitrogen shot operations while performing them using the CTs (QT 700, QT 800, QT 900, and QT 1000). The current work adopts the methodology of CT assessment based on a computational model built in MATLAB with respect to different oil well parameters in the upper Assam basin. This study takes an innovative approach by taking downhole temperature into account when determining the CT limit for QT 800, which signifies novelty in the current work. According to the computational analysis used in the study on CT limits, mechanical strain, thermal strain, and the combined strain of the CT material all affect CT elongation. This observation was often found to be a research gap in different research works as this aspect in previous studies was not considered while analysing CT operations. The findings of the present study highlight and draw the conclusion that temperature variations in the well and the CTU’s circulating fluid contribute linearly to CT strain. CT’s working limit diminishes with increasing internal and external pressure and diametrical growth, which eventually causes fatigue damage.
Prioritization of thermal energy techniques by employing picture fuzzy soft power average and geometric aggregation operators
Authors: Mahmood Tahir , Ahmmad Jabbar , Gwak Jeonghwan , Jan Naeem 
Published: January 2023

AbstractEnergy storage is a way of storing energy to reduce imbalances between demand and energy production. The ability to store electricity and use it later is one of the keys to reaching large quantities of renewable energy on the grid. There are several methods to store energy such as mechanical, electrical, chemical, electrochemical, and thermal energy. Regarding their operation, storage, and cost, the choice of these energy storage techniques appears to be interesting. This issue becomes very serious when there involves uncertainty. To consider this kind of uncertain information, a picture fuzzy soft set is found to be a more appropriate parameterization tool to deal with imprecise data. Based on the advanced structure of picture fuzzy soft set, here in this article, firstly, we have developed the notions of basic operational laws for picture fuzzy soft numbers. Then based on these developed operational laws, we have established the notions of picture fuzzy soft power average $$\left({\mathrm{PFS}}_{\mathrm{ft}}\mathrm{PA}\right)$$

PFS
ft

PA

, weighted picture fuzzy soft power average $$\left({\mathrm{WPFS}}_{\mathrm{ft}}\mathrm{PA}\right)$$

WPFS
ft

PA

and ordered weighted picture fuzzy soft power average $$\left({\mathrm{OWPFS}}_{\mathrm{ft}}\mathrm{PA}\right)$$

OWPFS
ft

PA

aggregation operators. Moreover, we have introduced the notions for picture fuzzy soft power geometric $$\left({\mathrm{PFS}}_{\mathrm{ft}}\mathrm{PG}\right)$$

PFS
ft

PG

, weighted picture fuzzy soft power geometric $$\left({\mathrm{WPFS}}_{\mathrm{ft}}\mathrm{PG}\right)$$

WPFS
ft

PG

and ordered weighted picture fuzzy soft power geometric $$\left({\mathrm{OWPFS}}_{\mathrm{ft}}\mathrm{PG}\right)$$

OWPFS
ft

PG

aggregation operators. Furthermore, we have established the application of picture fuzzy soft power aggregation operators for the selection of thermal energy storage techniques. For this, we have developed a decision-making approach along with an explanatory example to show the effective use of the developed theory. Furthermore, a comparative analysis of the introduced work shows the advancement of developed notions.
Elevated alpha diversity in disturbed sites obscures regional decline and homogenization of amphibian taxonomic, functional and phylogenetic diversity
Authors: Dehling D. Matthias , Dehling J. Maximilian 
Published: January 2023

AbstractLoss of natural habitat due to land-use change is one of the major threats to biodiversity worldwide. It not only affects the diversity of local species communities (alpha diversity) but can also lead to large-scale homogenization of community composition (reduced beta diversity) and loss of regional diversity (gamma diversity), but these effects are still rarely investigated. We assessed the impact of land-use change on taxonomic, functional and phylogenetic diversity of amphibians in Rwanda, both on the local (community-level) and regional scale (country-wide). Alpha diversity in local communities was higher in farmland than in natural habitats; however, species turnover among farmland sites was much lower than among natural sites, resulting in highly homogenized communities and reduced taxonomic, functional and phylogenetic gamma diversity in farmland across Rwanda. Amphibians found in farmland were mostly disturbance-tolerant species that are widespread in eastern Africa and beyond. In contrast, most of the regionally endemic frog species that make this region a continent-wide hotspot of amphibian diversity were found only in the natural habitats. Ongoing habitat conversion might result in further homogenization of amphibian communities across sub-Saharan Africa and the loss of regional endemism, unique evolutionary lineages, and multifunctionality.
Knowledge mining of unstructured information: application to cyber domain
Authors: Takko Tuomas , Bhattacharya Kunal , Lehto Martti , Jalasvirta Pertti , Cederberg Aapo , Kaski Kimmo 
Published: January 2023

AbstractInformation on cyber-related crimes, incidents, and conflicts is abundantly available in numerous open online sources. However, processing large volumes and streams of data is a challenging task for the analysts and experts, and entails the need for newer methods and techniques. In this article we present and implement a novel knowledge graph and knowledge mining framework for extracting the relevant information from free-form text about incidents in the cyber domain. The computational framework includes a machine learning-based pipeline for generating graphs of organizations, countries, industries, products and attackers with a non-technical cyber-ontology. The extracted knowledge graph is utilized to estimate the incidence of cyberattacks within a given graph configuration. We use publicly available collections of real cyber-incident reports to test the efficacy of our methods. The knowledge extraction is found to be sufficiently accurate, and the graph-based threat estimation demonstrates a level of correlation with the actual records of attacks. In practical use, an analyst utilizing the presented framework can infer additional information from the current cyber-landscape in terms of the risk to various entities and its propagation between industries and countries.
CID12261165, a flavonoid compound as antibacterial agents against quinolone-resistant Staphylococcus aureus
Authors: Morimoto Yuh , Aiba Yoshifumi , Miyanaga Kazuhiko , Hishinuma Tomomi , Cui Longzhu , Baba Tadashi , Hiramatsu Keiichi 
Published: January 2023

AbstractFlavonoids are plant-produced secondary metabolites that are found ubiquitously. We have previously reported that apigenin, a class of flavonoid, has unique antimicrobial activity against Staphylococcus aureus (S. aureus), one of the major human pathogens. Apigenin inhibited fluoroquinolone-resistant S. aureus with DNA gyrase harboring the quinolone-resistant S84L mutation but did not inhibit wild-type DNA gyrase. In this study, we describe five flavonoids, quercetin, luteolin, kaempferol, baicalein, and commercially available CID12261165, that show similar antimicrobial activity against fluoroquinolone-resistant S. aureus. Among them, CID12261165 was the most effective with MIC values of ≤ 4 mg/L against quinolone-resistant S. aureus strains. In vitro DNA cleavage and supercoiling assays demonstrated inhibitory activity of CID12261165 against mutated DNA gyrase, whereas activity against wild-type DNA gyrase was not observed. CID12261165 also inhibited quinolone-resistant Enterococci with an MIC value of 8 mg/L. While fluoroquinolone-resistant amino acid replacements can improve the fitness of bacterial cells, it is unknown why quinolone-susceptible S. aureus strains were predominant before the introduction of fluoroquinolone. The present study discusses the current discrepancies in the interpretation of antimicrobial activities of flavonoids, as well as the possible reasons for the preservation of wild-type DNA gyrase wherein the environmental flavonoids cannot be ignored.
Prognostic effect of albumin-to-alkaline phosphatase ratio on patients with hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Zhang Xinyuan , Xin Yujing , Chen Yi , Zhou Xiang 
Published: January 2023

AbstractThe prognostic value of albumin-to-alkaline phosphatase ratio (AAPR) in patients with hepatocellular carcinoma (HCC) remains controversial. This meta-analysis aims to evaluate the prognostic role of AAPR in patients with HCC. The databases of Web of Science, Embase, Cochrane Library and PubMed were comprehensively searched from inception to April 25, 2022. Pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated with Stata 16.0 software for the assessment of the relationship between AAPR and overall survival (OS) as well as recurrence-free survival (RFS) in patients with HCC. A total of 2634 patients from 12 cohorts were included in this meta-analysis. The pooled results showed that lower AAPR predicted poorer OS (HR 2.02, 95% CI 1.78–2.30). Similarly, pooled results demonstrated that lower AAPR also predicted poorer RFS (HR 1.88, 95% CI 1.37–2.57). The heterogeneity for RFS by multivariate analytic results and the publication bias for OS existed, however, the subgroup analysis, meta-regression analysis as well as adjustment using trim-and-fill analysis confirmed an association between AAPR and OS as well as RFS. This meta-analysis proves that lower AAPR in patients with HCC predicted inferior survival outcomes, and AAPR might be a promising indicator for the prognosis of HCC.
Stage distinctive communication networks of the online breast cancer community
Authors: Jo Wonkwang , Jang Sou Hyun , Shin Eun Kyong 
Published: January 2023

AbstractIn this study, we reveal the distinctive communication network structures and contents of online breast cancer community posts in accordance with different cancer stages. Using data collected from community.breastcancer.org, a major online breast cancer community (28,139 original posts and 663,748 replies), we traced the communication network structures and contents of replies associated with its severity. By combining network and quantitative content analyses, we deciphered the functions and utilities of health-related online communication. We found an inverse relationship between offline epidemiological prevalence and online communication activation. Despite the relatively small percentage of breast cancer patients, it was found that the more severe the condition of breast cancer, the more active online communication was. We further found that as pathological severity advances, communication networks move from informational exchange to emotional support. The capture of online social networks based on the cancer stage can help unpack the distinctive communication patterns found across different cancer severities. Our results provide insights into a possible online communication intervention design tailored to symptom severity.
The microstructure and mechanical properties of microwave-heated lunar simulants at different input powers under vacuum
Authors: Lim Sungwoo , Degli-Alessandrini Giulia , Bowen James , Anand Mahesh , Cowley Aidan 
Published: January 2023

AbstractTo achieve a sustainable human presence on the Moon, it is critical to develop technologies utilising the local resources (a.k.a. in-situ resource utilisation or ISRU) for construction and resource extraction. In this study, we investigate the viability of microwave heating of two lunar soil simulants (JSC-1A and OPRH3N) under vacuum conditions, to simulate a lunar surface environment compared to previous studies performed at atmospheric pressure. All simulants are thermally treated in a bespoke 2.45 GHz microwave apparatus using three input powers: 1000 W, 600 W and 250 W. The microstructures and mechanical properties of the microwaved samples are analysed to identify their potential applications. Our key findings are: (i) higher input powers generate materials in shorter fabrication times with higher mechanical strengths and higher yields despite the same total energy input; (ii) the microstructures of the microwaved samples under vacuum are very different from those under atmospheric conditions due to the widespread vesicles/bubbles; and (iii) different heating rates caused by different input powers can be utilised for specific ISRU purposes: higher input powers for extra-terrestrial construction and lower input powers for resource extraction. Findings from this study have significant implications for developing a microwave-heating payload for lunar ISRU demonstration missions.
Can Apple and Google continue as health app gatekeepers as well as distributors and developers?
Authors: Sadare Olamide , Melvin Tom , Harvey Hugh , Vollebregt Erik , Gilbert Stephen 
Published: January 2023

AbstractMobile apps are the primary means by which consumers access digital health and wellness software, with delivery dominated by the ‘Apple App Store’ and the ‘Google Play Store’. Through these virtual storefronts Apple and Google act as the distributor (and sometimes, importer) of many thousands of health and wellness apps into the EU, some of which have a medical purpose. As a result of changes to EU law which came into effect in May 2021, they must now ensure that apps are compliant with medical devices regulation and to inform authorities of serious incidents arising from their use. The extent to which these new rules are being complied with in practice is uneven, and in some areas unclear. In light of EU legislation related to competition, which came into effect in November 2022, it is also unclear how conflicts of interest can be managed between Apple and Google’s roles as gateway duopoly importers and distributors whilst also developers of their own competitive health products. Finally, with the proposed European health data space regulation, wellness apps will be voluntarily registered and labelled in a fashion more like medical devices than consumer software. We explore the implications of these new regulations and propose future models that could resolve the apparent conflicts. All stakeholders would benefit from improved app store models to sustainably evolve safer, better, and fairer provision of digital health applications in the EU. As EU legislation comes into force it could serve as a template for other regions globally.
Highly efficient construction of 2,3-disubstituted indoline derivatives by [4 + 1] annulation of sulfur ylides and o-sulfonamido aldimines
Authors: Xu Mengjiao , You Mengwei , Su Yang , Lu Boxue Ruan , Liu Ling , Lv Xin , Wang Shoulei , Mao Hui , Zhou Liejin 
Published: January 2023

A highly efficient [4 + 1] annulation of sulfur ylide salts and o-sulfonamido aldimines for construction of valuable 2,3-disubstituted indolines is reported. It is worth noting that indoles could also be synthesized by this cascade reaction.
Tumor-Fatigue-Sprechstunde der Bayerischen Krebsgesellschaft e.V.:
Studienprotokoll einer Beobachtungsstudie zur flächendeckenden
Versorgungsstruktur in Bayern
Authors: Müller Karolina , Fischer Irene , Koller Michael , Besseler Markus 
Published: January 2023

ZusammenfassungTumor-assoziierte Fatigue (TF) ist ein sehr belastender Zustand von anhaltender
Müdigkeit, Schwäche und Energiemangel auf körperlicher,
affektiver und kognitiver Ebene. TF tritt im Kontext einer Tumorerkrankung
und/oder ihrer Therapie auf und geht mit Einschränkungen von
Alltagsfunktionalität, Lebensqualität und Überlebenszeit
einher. Bisher mangelt es in Deutschland an Einrichtungen, die sich auf die
Identifikation therapierbarer Einflussfaktoren der TF sowie der Empfehlung
angemessener, evidenzbasierter Therapien spezialisiert haben. Die Bayerische
Krebsgesellschaft e.V. (BKG) hat seit 2013 mit insgesamt zehn Anlaufstellen eine
flächendeckende Versorgung in Bayern aufgebaut und bietet im Rahmen
ihrer Sprechstunde für Krebspatienten mit TF fundierte Diagnostik sowie
Beratung an. Bei der Konzeption und der Weiterentwicklung der Sprechstunde
wurden die jeweils gültigen Leitlinien berücksichtigt. Die
Sprechstunden werden von onkologisch und psychoonkologisch erfahrenen
Ärzten durchgeführt, die hinsichtlich TF geschult sind. Ziel
dieser prospektiven, multizentrischen Beobachtungsstudie ist es, den Ist-Zustand
der TF-Sprechstunde der BKG zu evaluieren. Dazu gehören die Analyse des
Angebots und Bedarfs der TF-Sprechstunde, die patientenberichtete TF vor der
TF-Sprechstunde und zehn Wochen danach, die Umsetzung empfohlener, gemeinsam
konsentierter Maßnahmen zur Reduktion der TF sowie die Analyse der
Stärken und des Verbesserungspotentials des gegenwärtigen
Systems. Die gewonnenen Ergebnisse sollen eine Übertragung auf eine
deutschlandweite Versorgung ermöglichen.
Status der stationären Behandlung psychisch erkrankter
Strafgefangener in allgemeinpsychiatrischen Abteilungen und
Kliniken
Authors: Grubbe Felix , Wagner Elias , Pogarell Oliver , Dudeck Manuela , Hasan Alkomiet 
Published: January 2023

Zusammenfassung
Hintergrund Stationär-psychiatrische Behandlungen von
Strafgefangenen sind in Deutschland je nach Bundesland und Justizvollzugsanstalt
unterschiedlich organisiert. Es gibt wenig Befunde bezüglich der
verschiedenen Möglichkeiten der Behandlung und der Sichtweise der
Kliniken zu dieser Thematik.
Ziel der Arbeit Ziel ist es, ein aktuelles Bild von der
Versorgungssituation bezüglich stationärer Behandlungen von
Strafgefangenen in der Allgemeinpsychiatrie und den damit verbundenen
Herausforderungen zu gewinnen.
Methodik Wir führten eine anonyme online-Befragung
bezüglich der Häufigkeit, des Umfanges und der Herausforderungen
bei der stationären Behandlung von Strafgefangenen durch. Zu dieser
Befragung wurden ca. 460 Chefärzt*innen deutscher
allgemeinpsychiatrischer Kliniken eingeladen. Neben deskriptiven Statistiken
berechneten wir Gruppen-Unterschiede nach Klinikart und nach subjektiver
Zuständigkeit für die stationäre Versorgung von
Strafgefangenen.
Ergebnisse Insgesamt nahmen 74 Chefärzt*innen teil.
51,4% der befragten Kliniken führten 2020
stationär-psychiatrische Behandlungen bei Strafgefangenen durch.
Gruppenunterschiede zwischen den Klinikarten fanden sich nur für das
Vorliegen von antizipierten Ängsten bei Mitpatient*innen.
Zwischen zuständigen und nicht zuständigen Kliniken fanden sich
diverse Unterschiede vor allem bezüglich organisatorischer Aspekte.
Diskussion Für die Behandlung von psychisch erkrankten
Strafgefangenen wurden sowohl organisatorische Hürden, als auch
Ängste bei Klinikpersonal und Mitpatient*innen durch die
Teilnehmenden genannt. Die Art der Klinik spielt hierbei eine untergeordnete
Rolle, entscheidender scheint die Zuständigkeit der Klinik für
die stationäre Versorgung psychisch erkrankter Strafgefangener zu
sein.
Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)
Authors: Bezerra Francisca Magnólia Diógenes Holanda , Vieira-Neto Antônio Eufrásio , Benevides Samara Casemiro , Tavares Kaio César Simiano , Ribeiro Antonia Deyse de Castro , Santos Sacha Aubrey Alves Rodrigues , Leite Gerlânia de Oliveira , Alves Magalhães Francisco Ernani , Campos Adriana Rolim 
Published: January 2023

AbstractThis study evaluates the pharmacological potential of cis-jasmone (CJ) in adult zebrafish (Danio rerio; aZF). Initially, aZF (n = 6/group) were pretreated (20 µL;
p. o.) with CJ (0.1 or 0.3 or 1.0 mg/mL) or vehicle (0.5% Tween 80). The animals were submitted to acute toxicity and locomotion tests, pentylenetetrazole-induced seizure,
carrageenan-induced abdominal edema, and cinnamaldehyde-, capsaicin-, menthol-, glutamate-, and acid saline-induced orofacial nociception. The possible mechanisms of anticonvulsant,
anxiolytic, and antinociceptive action were evaluated. The involvement of central afferent fibers sensitive to cinnamaldehyde and capsaicin and the effect of CJ on the relative gene
expression of TRPA1 and TRPV1 in the brain of aZF were also analyzed, in addition to the study of molecular docking between CJ and TRPA1, TRPV1 channels, and GABAA receptors. CJ
did not alter the locomotor behavior and showed pharmacological potential in all tested models with no toxicity. The anticonvulsant effect of CJ was prevented by flumazenil (GABAergic
antagonist). The anxiolytic-like effect of CJ was prevented by flumazenil and serotonergic antagonists. The antinociceptive effect was prevented by TRPA1 and TRPV1 antagonists. Chemical
ablation with capsaicin and cinnamaldehyde prevented the orofacial antinociceptive effect of CJ. Molecular docking studies indicate that CJ interacted with TRPA1, TRPV1, and GABAA
receptors. CJ inhibited the relative gene expression of TRPA1 and TRPV1. CJ has pharmacological potential for the treatment of seizures, anxiety, inflammation, and acute orofacial
nociception. These effects are obtained by modulating the GABAergic and serotonergic systems, as well as the TRPs and ASIC channels.
Akzeptanz der Teledermatologie: Ergebnisse einer Befragung
sächsischer Haus- und HautärztInnen
Authors: Kriwy Peter , Nötzold Anett , Seitz Anna-Theresa , Berger Roger 
Published: January 2023

Zusammenfassung
Ziel der Studie Mit der Befragung sächsischer Haus- und
HautärztInnen wird die Akzeptanz bzw. Nutzungsabsicht einer
teledermatologischen Anwendung untersucht. Vor dem Hintergrund der
demographischen Entwicklung in Sachsen und der geringen regionalen
FachärztInnendichte ist dieses Bundesland zur Durchführung einer
solchen Befragung besonders gut geeignet.
Methodik Auf der Grundlage einer geschichteten Zufallsauswahl wurden 108
sächsische ÄrztInnen schriftlich postalisch bzw. online befragt
(60 HausärztInnen und 48 HautärztInnen, Teilnahmequote 23,5
Prozent). Die Theorie der Akzeptanz und Nutzung von Technologie (UTAUT-Modell)
wurde auf die Teledermatologie angewendet. Vier zentrale Hypothesen wurden
abgeleitet und mit logistischen Regressionen getestet.
Ergebnisse Die getesteten Hypothesen, die Zusammenhänge zwischen
Leistungserwartung, Aufwandserwartung, sozialem Einfluss und erleichternden
Rahmenbedingungen und der Nutzungsabsicht der Teledermatologie postulieren,
werden zum Teil bestätigt. Zudem zeigt sich für Teledermatologie
ein Potential bei sächsischen HausärztInnen, da 9,5%
ihrer PatientInnen wegen Hauterkrankungen in die Praxis kommen. 78% der
HausärztInnen bieten Hautkrebsscreenings an.
Schlussfolgerung Die Bevölkerungsstruktur und die geringe
Arztdichte in Sachsen wären günstige Voraussetzungen zur
Implementation der Teledermatologie. Tiefergehende Bedenken der Haus- und
HautärztInnen gegenüber der Teledermatologie konnten aufgrund
der Befragungsergebnisse nicht festgestellt werden.