bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lenvatinib with or without Stereotactic Body Radiotherapy for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: a retrospective study
Authors: Ji Xiaoquan , Xu Zhe , Sun Jing , Li Wengang , Duan Xuezhang , Wang Quan 
Published: January 2023

Abstract
Background and objectives: Patients with hepatocellular carcinoma (HCC) involving portal vein tumor thrombosis (PVTT) are presently lacking effective treatment options. We aimed to compare the efficacy and safety of lenvatinib with or without SBRT for HCC with PVTT.
Materials and Methods: This retrospective analysis included 37 patients treated with lenvatinib in combination with SBRT and 77 patients treated with lenvatinib alone from August 2018 to August 2021. Overall survival (OS), progression-free survival (PFS), intrahepatic PFS (IHPFS) and objective remission rate (ORR) were compared between the two groups, while adverse events (AEs) was analyzed between the two groups to assess safety profiles.
Results: Median OS, PFS and IHPFS were significantly prolonged in the combination treatment group compared with the single treatment group (median OS, 19.3 vs. 11.2 months, p < 0.001; median PFS: 10.3 vs. 5.3 months, p < 0.001; median IHPFS, 10.7 vs. 5.3 months, p < 0.001). Moreover, a higher ORR (56.8% vs. 20.8%, P < 0.001) were observed in the lenvatinib combined with SBRT group. In subgroup analyses of Vp1-2 and Vp3-4 group, median OS, PFS and IHPFS were also significantly longer in the lenvatinib combined with SBRT group than those in the lenvatinib alone group. AEs in the combined therapy group were mostly manageable and the incidence was not statistically significant compared to the monotherapy group.
Conclusion: Lenvatinib plus SBRT had a significantly better survival benefit than lenvatinib monotherapy in the treatment of HCC patients with PVTT and was well tolerated.
An envelope operator for full convexity to define polyhedral models in digital spaces
Authors: Feschet Fabien , Lachaud Jacques-Olivier 
Published: January 2023

Abstract
In a recent work, full convexity has been proposed as an alternative definition of digital convexity. It solves many problems related to its usual definitions, for instance: fully convex sets are digitally convex in the usual sense, but are also connected and simply connected. However, full convexity is not a monotone property hence intersections of fully convex sets may be neither fully convex nor connected. This defect might forbid digital polyhedral models with fully convex faces and edges. This can be detrimental since classical standard and naive planes are fully convex. In this paper we study several methods that builds a fully convex set from a digital set. One is particularly appealing and is based on an iterative process: this envelope operator solves in arbitrary dimension the problem of extending a digital set into a fully convex set, while leaving fully convex sets invariant. This extension naturally leads to digital polyhedra whose cells are fully convex. Then a relative envelope operator is proposed, which can be used to force digital planarity of fully convex sets. We provide experiments showing that our method produces coherent polyhedral models for any polyhedron in arbitrary dimension. Finally we study how we can speed up full convexity checks and envelope operations, with a worst-case complexity lowered by a factor 2d in Zd.
Eco-friendly green construction of 4-Aryl-tetrazolo-[1,5-a][1,8]naphthyridine scaffolds and their in vitro anti-microbial and molecular modeling studies
Authors: Sonyanaik Banoth , Ravi Dharavath , Shyam Perugu , kishore Kamal , Ashok Alishala , Sakram Boda 
Published: January 2023

Abstract
An efficient eco-friendly synthesis of 4-aryl tetrazolo[1,5-a][1,8]naphthyridine derivatives have been successfully prepared through microwave method in short reaction time. The microwave method has unique advantages, short reaction time, easy workup procedure, and simple purification of the products. Synthesized the entire molecule evaluated for their antimicrobial activity among them compounds 6g and 6a demonstrated highest anti-microbial activity. Moreover, in silico molecular modeling evaluation has done by considering docking scores, hydrogen bond interactions, affinity, and the short distance between ligand and receptor. All the molecules good docking results have shown that binding interactions with the target protein and obtained results were well complemented to the antimicrobial activity.
Copper-catalyzed C2-selective alkynylation of chromones via 1,4-conjugate addition
Authors: Li Yan-Wu , Lei Jie , Chen Zhong-Zhu , Lv Meng-Lan 
Published: January 2023

Abstract
Copper-catalyzed selective alkynylation with N-propargyl carboxamides as nucleophiles has been successfully developed for the synthesis of C2-functionalized chromanones. Under optimized reaction conditions, 21 examples were obtained in one-pot procedure through 1,4-conjugate addition. This protocol features readily available feedstocks, easy operations and moderate to good yields, which provides viable access to pharmacologically active C2-functionalized chromanones.
Adverse Effects of Hyperbaric Oxygen Therapy: a systematic review and meta-analysis
Authors: Zhang Yu-Yao , Zhou Yi-Jun , Jia Yuan-Yuan , Wang Tian-Tian , Meng Dian-Huai 
Published: January 2023

Abstract
Objective
Hyperbaric oxygen therapy is one of the common clinical treatments, but adverse effects have hampered and limited the clinical application and promotion of hyperbaric oxygen therapy. We conducted a systematic review and meta-analysis of the adverse effects of hyperbaric oxygen therapy to provide a theoretical basis for clinical treatment.
Methods
Three electronic databases (Pubmed, Web of Science, Cochrane) were comprehensively searched for randomized clinical trials (RCTs) from March, 2012 to October, 2022. Two reviewers independently screened titles and abstracts for eligibility and assessed the quality of the included studies. The meta-analysis was performed using RevMan 5.3.
Results
A total of 26 RCTs involving 1497 participants were identified. ①HBOT group reported more adverse effects (29.81% vs 10.34%, P < 0.05). ②The most frequent side effect of HBOT is ear discomfort (124 cases). ③When the courses of hyperbaric oxygen was > 7 sessions, the incidence of adverse effects was higher than that of the control group; when the course of HBOT was ≤ 7 sessions, the adverse effects caused by hyperbaric oxygen were comparatively lower.④ When chamber pressures are above 2.0 ATA, the incidence of adverse effects is higher than that of the control group; when chamber pressure is below 2.0 ATA, HBOT is relatively safe.
Conclusion
HBOT is more likely to cause adverse reactions when the course of HBOT is > 7 sessions and chamber pressure is above 2.0 ATA.
Characterization of prehospital time delay in primary percutaneous coronary intervention for acute myocardial infarction: Analysis of geographical infrastructure-dependent and - independent components
Authors: Oyatani Keisuke , Koyama Masayuki , Himuro Nobuaki , Miura Tetsuji , Ohnishi Hirofumi 
Published: January 2023

Abstract
Background
Prehospital delay in reaching a percutaneous coronary intervention (PCI) facility is a major problem that prevents early coronary reperfusion in patients with ST-elevation myocardial infarction (STEMI). This study aimed to identify modifiable factors that contribute to the interval from symptom onset to arrival at a PCI-capable center, focusing on the geographical infrastructure-dependent and -independent factors.
Methods
We analyzed data from 603 STEMI patients who received primary PCI within 12 h of symptom onset in the Hokkaido Acute Coronary Care Survey. We used geographical information system software to calculate the minimum prehospital system time (min-PST), which represents the time required to reach a PCI facility based on geographical factors. We then subtracted the min-PST from the onset-to-door-time (ODT) to find the estimated delay-in-arrival-to-door (eDAD), which represents the time required to reach a PCI facility independent of geographical factors.
Results
The door-to-balloon-time (median [IQR]: 63 [44, 90] min) was shorter than ODT (median [IQR]: 104 [56, 204] min) regardless of the type of transportation. However, 44% of patients had more than 120 min ODT. The min-PST (median [IQR]: 3.7 [2.2, 12.0] min) varied widely among patients, with a maximum of 156 min. Prolongation of the eDAD (median [IQR]: 89.1 [49, 180] min) was associated with older age, absence of a witness, onset at night, no EMS call, and transfer via a non-PCI facility. If the eDAD was zero, the ODT was projected to be less than 120 min in more than 90% of patients.
Conclusions
The contribution of geographical infrastructure-dependent time in prehospital delay was substantially smaller than that of geographical infrastructure-independent time. Intervention to shorten eDAD by focusing on factors such as older age, absence of a witness, onset at night, no EMS call, and transfer via a non-PCI facility appears to be an important strategy for reducing ODT in STEMI patients. Additionally, the eDAD may be useful for evaluating the quality of STEMI patient transports in areas with different geographical conditions.
Optimization of L-asparaginase from Enterobacter aesburiae via response surface approach
Authors: Manhas Sweeta , Khan Bushra , Sharma Vikas , Koul Diksha , Chaubey Asha , Wani Owais Ali , Malik A. Raouf 
Published: January 2023

Abstract
L-asparaginase, an important biopharmaceutical, has been a boon to cancer patients, especially for the therapeutic treatment of acute lymphoblastic leukemia. However, asparaginase formulations from E. coli and Erwinia species currently being used are associated with potential side effects causing hindrances towards a successful therapeutic treatment. Therefore, optimization and production of asparaginase from varied microbial sources has been the aim of several studies to overcome the hypersensitive and toxicological responses associated with presently used drug formulations. In this study, the possibility of using Enterobacter aesburiae strain R16C1/MT93543isolated from black gram rhizospheric soil sample as L-asparaginase source of industrial importance, was investigated. Different fermentation process parameters for the production of enzyme were optimized using submerged fermentation in shake flask. Box Behnken design was used to optimize and study individual as well as interactive effect of rpm, inoculum size (%) and temperature for asparaginase activity. Comparable values for enzyme activity were obtained from experimental results and software predicted values. As per interaction data obtained for the selected fermentation parameters, rpm, size of inoculum and temperature showed significant effects at interactive levels, thus, showing effect on production of enzyme. A significant improvement in enzyme activity was obtained using optimized environment. Higher enzyme activity of 40.36 U/ml was observed in M9 medium which was 4.4-fold higher than the initial activity of enzyme.
Easyton ® transpalpebral versus Perkins applanation tonometry in different clinical populations
Authors: Montolío-Marzo Elena , Morales-Fernandez Laura , Saenz-Frances Federico , Garcia-Saenz Sofia , García-Feijoo Julian , Piñero David P , Martinez-de-la-Casa Jose Maria 
Published: January 2023

Abstract
Objective
To compare intraocular pressure (IOP) measurements obtained using the new transpalpebral Easyton® tonometer and Perkins applanation tonometer (PAT) in three different clinical populations.
Methods
The participants of this prospective study were 84 subjects divided into the groups: 22 healthy children (G1), 42 healthy adults (G2), and 20 adult patients with primary open angle glaucoma (G3). The data recorded in 84 eyes of these subjects were age, sex, eye, central corneal thickness (CCT) and axial length (AL). In all eyes, IOP was determined in the same examination room by the same experienced examiner using Easyton® and PAT in random order.
Results
Mean differences in IOP readings between Easyton® and PAT were 0.45 ± 1.97 (p = 0.295), -0.15 ± 2.13 (p = 0.654), -1.65 ± 3.22 (p = 0.033), and − 0.018 ± 2.500 mmHg (p = 0.500) in the groups G1, G2, G3 and whole sample (G4), respectively. Correlations between Easyton® and PAT IOP values were 0.668 (p = 0.001) for G1, 0.463 (p = 0.002) for G2, 0.680 (p < 0.001) for G3 and 0.605 (p < 0.001) for G4. Moderate to good agreement between the two tonometers was found in all groups according to intraclass correlation coefficients, which were 0.794 (p < 0.001) for G1, 0.632 (p < 0.001) for G2, 0.809 (p < 0.001) for G3, and 0.740 (p < 0.001) for G4. The lower and upper limits of agreement between the devices were − 5.1 and 4.7 mmHg, respectively. No correlation was noted between CCT or AL and the Easyton® IOP measurements.
Conclusion
IOP measurements obtained with Easyton® and PAT show an acceptable level of agreement both in healthy individuals and in patients with glaucoma.
Assessment of the efficiency of the routine epidemiological surveillance system for malaria at the Tambacounda Health District, Senegal
Authors: Gadiaga Tidiane , Ba Mouhamadou Faly , Sagna Siré , Cissé Bayal , Diallo Boubacar , Ndiaye Samba , Bonang Urbain Ithiar , Diamé Mariama , Diallo Fatimata , Gaye Seynabou , Sene Doudou , Ndoye Tidiane , Lo Aminata Colle , Diallo Abdoulaye , Manga Isaac , Thiam Sylla , Ciré Elhadj Konko Ciré , Ndiaye Jean Louis Abdou 
Published: January 2023

Abstract
Introduction: As part of the fight against malaria, epidemiological surveillance (ES) is one of the key pillars of the global technical strategy 2016-2030 to combat this disease. However, in the south-east of Senegal, where malaria poses a major public health problem, epidemiological surveillance has until recently been very neglected. To help reduce malaria-related morbidity and mortality in Senegal, an evaluation of the routine malaria ES system was conducted in the Tambacounda Health District in 2021.
Methods: We conducted a cross-sectional, descriptive survey of 27 health structures in Tambacounda district from 20 February to 1 March 2022.
Results: Overall, the routine ES system in the district was acceptable according to its users, with satisfactory tool filling time in 96.3% of the structures in our study, a cumulative completeness of reports at 92% despite a 77% promptness. The data collected at the services delivery points (SDP) level allowed a representativeness of the ES system in 100% of health facilities. The ES system was also rated as simple by 74.1% of SDP managers even though only 55.6% of them were trained. However, the stability of the system was low because 55.6% of SDP had staff to ensure the continuity of ES service despite the availability of management tools (100%) and the telephone network (96.3%). The same was true for the usefulness of the ES because only 25.9% of SDP managers analyzed their produced data. The reported ES and malaria morbidity data were not adequate. On the other hand, the ES system was reactive with a speed of transmission of information at 96.3% and a possibility of rapid diagnosis and management of cases at 100%.
Conclusion: The routine malaria ES system at the level of health facilities in Tambacounda district was acceptable, simple, flexible, representative, and responsive. However, an increase in qualified staff at the health posts, capacity strengthening of the ES staff, regular supervision of SDP are needed essential to make the district's malaria surveillance system more efficient.
Roadsoil contamination by hydrocarbon aromatic polycyclic: Level and impact on germination of Lycopsersicum esculentum and Cucumis sativus
Authors: mbadra chaker , gargouri kamel , mbarek hadda ben , Trabelsi Lina , Ncube Bhekumtheto , chaabouni Semia ellouz 
Published: January 2023

Abstract
The study of three roadsoil contamination in the Sfax region by polycyclic aromatic hydrocarbons showed a significant variation between the three sites and proportional to the distance from the road. The variation between the physicochemical characteristics of three soils influenced the spatial distribution of polycyclic aromatic hydroacarbons. Quantitatively, the soils near Manzel Chaker road had the highest content followed by those of the Tunis road soil . Qualitatively, chrysene, benzo (b) fluorenthene;benzo (a) anthracene and Indeno (1.2.3.cd) pyrene were the most abundant compounds. These contaminants, with naphthalene and fluorenthene, affected the germination and aerial growth of tomato but with no significant effect on the germination and growth of cucumber which has shown resistance to pollution by polycylic aromatic hydrocarbons. The use of PCA and regression between parameters indicated that these compounds which are in mixture in soil have disturbed the germinative capacity, the speed of germination and the aerial elongation of tomato. In the same soils, the cucumber showed resistance to this contamination and its germination was not affected.
Graphene quantum dots harvest anti-trypanosomatid efficacy by disrupting antioxidant networks centered on trypanothione reductase
Authors: Zhang Di , Ju Rui , Li Limei , Yang Lilian , Jia Qianwen , Lei Rong , Wang Na , Han Xiaofei , Wang Xinyi 
Published: January 2023

Abstract

Background Trypanosomiasis is a highly lethal infectious disease caused by trypanosome, leading to a severe social and economic burden worldwide. Due to the lack of mechanism research, application of the promising nanomaterials and nanotechnologies in treatment of trypanosomiasis is limited. Results Herein, the toxicological effects induced by graphene quantum dots (GQDs) onT. bruceiand the underlying mechanism are investigated. First, the biological/cytotoxic effects are evaluated, including endotytosis, cell viability, apoptosis, ROS production and morphological defects of subcellular organelles. Considering the few experimentally-determined 3D structures ofT. bruceiproteins, next, a computed structure database ofT. bruceigenome-wide proteins is constructed from I-TASSER, AlphaFold2 and MD simulation. Then, the database is used for docking with GQDs, and two goups of potential target proteins with transporter activity and antioxidant activity are screened out. Last, TryR stands out as a vital target due to its high binding energy with GQDs at active site and its key role in the trypanothione-dependent antioxidant network ofT. brucei, which is further verified by theoretical (MD simulation) and experimental (BLI, inhibition of enzyme activity) means. Conclusions Evidences from this study suggest that GQD-induced cytotoxicity onT. bruceiresults from interference of GQDs with the lineage-specific antioxidant network with TryR as a key target. These findings provide theoretical insights into the rational design of nanomedical materials for trypanosomiasis.
Validation of quercetin in the treatment of colon cancer with diabetes via network pharmacology and molecular dynamics simulation
Authors: Wang Mingqing , Cao Guodong , Zhou Weiguo , Cao Wei , Yang Kang , Zhang Xun , Zhang Peng , Zhang Zehua , Chen Bo , Hu Kongwang , Xiong Maoming 
Published: January 2023

Abstract
Objectives
Patients suffering from colon cancer with diabetes (CRC-Diabetes) are more likely to metastasis and relapse when compare with colon cancer (CRC). However, there is a lack of a prognostic model and efficient treatment for CRC-Diabetes. Based on these clinical requirements, this study built a prognosis model for CRC-Diabetes and analyzed whether quercetin could be used for CRC-Diabetes treatment through network pharmacology, Molecular dynamics simulation and bioinformatics .
Methods
Firstly, the differentially expressed genes (DEG) in colon cancer and the related genes in diabetes were screened, and the intersection genes of the two gene clusters were used to construct the prognosis model. Then the potential prognostic markers were screened by univariate Cox proportional hazards regression and lasso regression. Furthermore, multivariate Cox proportional hazards regression was used to construct the prognosis model of CRC-Diabetes. Consequently, quercetin related target genes were screened. The intersection of quercetin target genes with CRC-Diabetes genes was used to find the potential target for quercetin in the treatment of CRC-Diabetes. Molecular docking and molecular dynamics simulation were used to screen reliable targets for quercetin in treatment of CRC-Diabetes.
Results
There are 1008 intersection genes between colon cancer and diabetes. The constructed multivariate Cox proportional hazards regression model based on the above genes shows that the ROC values of 1, 3 and 5 years are 0.787, 0.793 and 0.85 respectively. There are 101 intersection genes in quercetin and CRC-Diabetes. Through molecular docking, seven proteins (HMOX1, ACE, MYC, MMP9, PLAU, MMP3, MMP1) were selected as potential targets of quercetin. We conducted molecular dynamics simulation of quercetin and the above proteins respectively, and found that the binding structure of quercetin with MMP9 and PLAU was relatively stable, which can be considered as a reliable target for quercetin treatment of CRC-Diabetes.
Conclusions
Based on TCGA, TTD, Drugbank and other databases, a prediction model that can effectively predict the prognosis of colon cancer patients with diabetes was constructed. Quercetin can treat colon cancer patients with diabetes by influencing PLAU and its downstream pathways.
How the micro-mechanical stability of carbides in chromium-rich hardfacings influences the impact-abrasion resistance at elevated temperatures
Authors: Rojacz Harald , Katsich Christian , Varga Markus , Badisch Ewald 
Published: January 2023

Abstract

Highly loaded wear components in applications such as crushers or sieves suffer from combined impact and abrasive wear, in the worst case exaggerated by high operation temperatures. Hardfacings based on the system FeCrC with high hardphase content are promising candidates for such applications. Understanding of the influence of precipitated carbides or carbo-borides on the impact-abrasive wear resistance is therefore of high importance to increase the lifetime, decrease downtime as well as maintenance costs.
In this study, two different FeCrC-based hardfacings were chosen for investigation, an FeCrC-alloy and a complex alloyed FeCrNbMoBC type. A thorough microstructural analysis was performed via scanning electron microscopy. Here, present hardphases, namely chromium carbides, chromium carbo-borides as well as niobium carbides were found. To evaluate the hardness H and Young’s modulus E nanoindentation measurements were performed and the plasticity indicating ratios H/E and H³/E² were derived. Scratch tests at elevated temperatures were performed identifying critical loads for carbide displacement and fracture. Those critical loads as well as the plasticity indexing parameters were correlated with the impact-abrasion behaviour of the two hardfacings via high-temperature cyclic impact abrasion tests up to 500°C. Results showed higher impact-abrasion resistance of the complex-alloyed FeCrC-based hardfacing due to better stability of the carbides as well as optimal ratios H/E and H³/E² indicating increased plasticity and thereby better impact resistance.