bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Causal Effects of Lifestyle Factors on Osteoarthritis: A Two-sample Mendelian Randomisation Study
Authors: Ho Justin , Mak Christopher Chi Hang , Lau Lawrence Chun Man , To Kendrick , Khan Wasim 
Published: January 2025

Background:
Modern sedentary lifestyles are prevalent among individuals with osteoarthritis.
However, direct evidence linking such behaviours as causative factors of osteoarthritis
remain limited due to the presence of confounding variables.

Objective:
This study aims to determine the extent to which lifestyle factors have causal effects on
osteoarthritis through a two-sample Mendelian randomisation (MR) study.

Methods:
Exposure-outcome relationships were evaluated using inverse variance weighted twosample
MR and summary statistics of genome-wide association studies of lifestyle factors and osteoarthritis.
Weighted median, MR-PRESSO, and MR-Egger regression were used as sensitivity
analyses. We obtained causality estimates, 95% confidence intervals (CI), and P-values from each
MR method. Steiger filtering and radial filtering were used to exclude SNPs demonstrating reverse
causality and significant heterogeneity, respectively.

Results:
MR analyses demonstrated that certain lifestyle factors had causal effects on osteoarthritis,
particularly insomnia (OR 1.09 (0.387-1.79), P = 0.0024), BMI (OR 6.45 (4.48-8.42), P =
1.38e-10) and protein intake (OR 2.94 (0.361-5.52), P = 0.026). Effects were consistent across sensitivity
analyses using median-based MR methods. ZNF131 & SEMA3F, and potentially RWDD2B
& USP8 are genetic loci identified to mediate these causal effects.

Conclusion:
Our results illustrate that lifetime exposure to certain lifestyle factors has causal effects
on osteoarthritis. Further studies are required to determine the efficacy of lifestyle-based interventions
in reducing the population-wide disease burden of osteoarthritis.
Maternal and Perinatal Outcome in Acute Fatty Liver of Pregnancy
Authors: Karnamadakala Shubhada , K Shraddha Shetty , Shetty Suprajna 
Published: January 2025

Background:
Acute Fatty Liver of Pregnancy (AFLP) is a rare obstetric condition that
can lead to maternal and perinatal complications.

Aim and Objectives:
This study aimed to study the pregnancy outcome in Acute fatty liver of Pregnancy
(AFLP). In particular, this study aimed to study the clinical features of the condition and its
effect on maternal and perinatal outcomes.

Materials and Methods:
A retrospective analysis of seven cases diagnosed with AFLP over a span
of three years was performed. The clinical records of these women were reviewed for clinical features,
laboratory investigations, and maternal and perinatal outcomes.

Results:
The incidence of AFLP was 4/10,000 births. A total of 6(85.7%) women presented during
the third trimester of pregnancy. A total of 4(57%) of them presented after 36 weeks of gestation. A
total of 6(85.7%) women presented with jaundice, and all presented with sudden onset nonspecific
symptoms, including abdominal pain and vomiting. Pregnancy was terminated by cesarean section
in 6 cases. Maternal mortality was noted in 6(85.7%) of women. All six women were diagnosed
with Acute kidney injury and coagulopathy. One woman had developed encephalopathy and altered
sensorium. Further, 2(28.5%) women had intrauterine fetal demise at the time of presentation, and
1(14.3%) had an early neonatal death.

Conclusion:
AFLP is a rare clinical syndrome with rapid and dramatic progression, beginning initially
with non-specific symptoms and evolving into coagulopathy, acute kidney injury, and death,
resulting in alarming maternal and perinatal mortality. Early diagnosis is challenging due to the
non-specificity of symptoms, but crucial and prompt termination of pregnancy is the need of the
hour. Nonetheless, supportive treatment and a multidisciplinary approach may significantly improve
prognosis.
White Matter Fiber Bundle Alterations Correlate with Gait and Cognitive
Impairments in Parkinson’s Disease based on HARDI Data
Authors: Dong Lining , Zhang Mingkai , Wang Zheng , Yan Ying , An Ran , Wang Zhenchang , Wei Xuan 
Published: January 2025

Background:
The neuroanatomical basis of white matter fiber tracts in gait impairments in individuals suffering from Parkinson’s Disease (PD) is unclear.

Methods:
Twenty-four individuals living with PD and 29 Healthy Controls (HCs) were included. For each participant, two-shell High Angular Resolution
Diffusion Imaging (HARDI) and high-resolution 3D structural images were acquired using the 3T MRI. Diffusion-weighted data preprocessing
was performed using the orientation distribution function to trace the main fiber tracts in PD individuals. Clinical characteristics between the two
groups were compared, and the correlation between the FA value and behavioral data was analyzed. Quantitative gait and clinical parameters were
recorded in PD at ON and OFF states, respectively.

Results:
The mean tract-specific FA values of the right Cingulum Cingulate (rCC) were statistically different between the PD group and the HC group (p
=0.047). The FA value of 34-58 equidistant nodes in rCC was positively correlated with Mini-Mental State Examination (MMSE) (r=0.527,
p=0.024), Berg Balance Scale (BBS)-OFF (r=0.480, p =0.040), and BBS-ON (r=0.528, p =0.024) scores, while it was negatively correlated with
the MDS-UPDRS-III-ON score (r=-0.502, p =0.030). Regarding the gait analysis, the FA value was significantly correlated with velocity, cadence,
and stride time of the pace and rhythm domains in both ‘ON’ and ‘OFF’ states, respectively (p<0.05).

Conclusion:
This study served as an initial exploration to establish that HARDI sequences could be employed as a robust tool for analyzing microstructural
alterations in white matter fiber bundles among PD patients, although the sample size was small. We confirmed microstructural integrity
impairment of rCC to be significantly associated with both gait and cognitive deficits in patients with PD. Early detection of microstructural
changes in rCC and targeted treatment can help improve behavioral disorders. In the future, we intend to further integrate multimodal data with
assessments of patient behavior both prior to and following intervention. We will validate our findings within an independent cohort to monitor
disease progression and evaluate the efficacy of therapeutic interventions.
Ubiquitination-related Gene UBTD1 Mediates Poor Prognosis of Colorectal Cancer and Affects Colorectal Cancer Cell Proliferation and Ferroptosis
Authors: Jin Yuzhao , Liao Luyu , Chen Qianping , Tang Bufu , Jiang Jin , Zhu Ji , Bai Minghua , Guo Lingjiao 
Published: January 2025

Background:
Colorectal cancer (CRC) is the third most common cancer worldwide,
and its occurrence and progression are often regulated by genetic and hereditary factors. Ubiquitination
and the associated ubiquitin-binding enzymes and ligases regulate the tumor microenvironment
and antitumor immunity to mediate tumor pathogenesis and progression. In this study, we examined
the molecular characteristics and immunomodulatory effects of ubiquitination-associated
genes that mediate CRC prognosis.

Methods:
The ubiquitination-related gene ubiquitin domain-containing protein 1 (UBTD1) was
identified using bioinformatics and single-cell analyses. Subsequently, the ability of UBTD1 to
predict CRC prognosis and immune checkpoint correlation was analyzed, the potential drug telatinib
targeting UBTD1 was explored, and the correlation between UBTD1 and ferroptosis was analyzed.
The role of UBTD1 in CRC and ferroptosis was verified using immunohistochemistry,
gene knockout, western blot, cell cloning, and immunofluorescence.

Results:
UBTD1 was identified as a significant prognostic and predictive gene for CRC and was
involved in regulating immune checkpoint levels and immune cell function of CRC patients with
CRC. High UBTD1 expression was found to enhance the presence of immune checkpoints that induce
immune escape and inhibit ferroptosis onset. Telatinib may be a potential therapeutic drug
targeting UBTD1.

Conclusion:
Our study demonstrated that UBTD1 is a prognostic marker for CRC in the regulation
of ubiquitination and the tumor immune microenvironment and may serve as a modulator of
ferroptosis.
PKE-Ubsite: A Ubiquitylation Site Predictor for Plants Based on Multiple Encoders and Ensemble Deep Learning Framework
Authors: Wang Xin , Zhang Zi Meng , Liu Chang 
Published: January 2025

Introduction:
Ubiquitylation, a key post-translational modification [PTM], has significant
influences on the structures, activities, and functions of proteins and is linked to various diseases.
Traditional experimental identification and characterization methods for identifying ubiquitylation
sites [Ubsites] are time-consuming, expensive, and labor-intensive if prior knowledge concerning
ubiquitylation is absent. Nevertheless, most methods reported for predictions of Ubsites are based on
traditional machine learning. Owing to the increased availability of genomic and proteomic samples,
deep learning-based recognition methods for Ubsites are becoming increasingly popular.

Method:
In this study, we propose a new feature extraction method, pKcode, based on only seven
physicochemical features of amino acids [AAs]. The pKcode captures both the biochemical context
and precise sequence locations of AAs around the Ubsites, improving the predictive capability for
ubiquitination. We created the pKPAP encoding scheme by integrating the pKcode with
PSDAAP, AAC, and PWAA, resulting in an all-encompassing feature representation. Concurrently,
we developed the PKE- Ubsite.

Result:
Ubsite model, a new ensemble prediction framework, amalgamates the power of classifiers in
five pipelines: three bidirectional long short-term memory [BiLSTM] networks, one convolutional neural
network [CNN], and one random forest [RF] classifier. Each classifier uses an optimized combination
of encoding features, and an integrated classification is achieved through a voting mechanism.

Conclusion:
Finally, compared with existing models on an independent test set, our model has an accuracy
of 0.8368, an F1-score of 0.8430, a precision of 0.8124, a recall of 0.8760, and an AUC of
0.9103, which are superior to all methods reported to date. Overall, PKE-Ubsite may facilitate a
thorough understanding of ubiquitylation.
Association of Interleukin-4 Receptor α Chain I50V Gene Variant (rs1805010) and Asthma in Iranian Population: A Case-control Study
Authors: Mowahedi Masouma , Aramesh Azam , Khouzani Mozhgan Sorkhi , Khouzani Marjan Sorkhi , Daryanoush Saeed , Samet Mohammad , Samadi Morteza 
Published: January 2025

Background
Asthma is one of the respiratory disorders caused by chronic airway inflammation. IL-4 has been identified as one of the participating interleukins in the severity of asthma.

Objective
A case-control study was conducted to determine the association of rs1805010, a single nucleotide polymorphism in the interleukin 4 receptor α chain, with asthma and immunoglobulin E and IL-17A serum levels in Iranian populations.

Methods
ELISA was used to investigate the relationship between three different varieties of SNP I50V and serum IL-17A levels, as well as total IgE levels. Based on GINA criteria, patients were classified into mild, moderate, and severe groups based on the association between SNP I50V, IL-17A, and total IgE. In order to analyze the data, the student-t-test and the one-way ANOVA were used.

Results
The SNP I50V was associated with asthma in a significant way (p = 0.001). IL-17A and total IgE levels were significantly higher in asthmatic patients than in control participants (p 0.05 and p 0.021, respectively), but neither showed any association with SNP I50V in the asthmatic patients.

Conclusion
Asthma patients have a higher prevalence of the I allele, reflecting the significance of Th2 cells. Although total IgE and IL-17A levels increased in both disease subgroups, total IgE level augmentation correlates directly with disease severity, while IL-17A level enhancement does not.
Indigenous Placenta Disposal: The Views of Midwives and Traditional Birth Attendants/Indigenous Knowledge Holders in Tshwane District, Gauteng Province, South Africa
Authors: Moeti Cecilia , Mulaudzi Fhumulani Mavis , Rasweswe Molatelo Melitah 
Published: January 2025

Background
Prior to the development of modern obstetric services, indigenous people had their own ways of disposing placenta, which are still practiced in some communities. However, persistent gaps exist in the South African healthcare system that deals with the integration of indigenous knowledge and Western medical services due to constraints in knowledge and expertise.

Methods
A qualitative approach using explorative design guided by the 5D appreciative inquiry model was employed. The participants were ten midwives, four traditional midwives, and six indigenous knowledge holders, who were recruited through a purposive sampling method. Data were collected through semi-structured individual interviews. Content data analysis was followed.

Results
Knowledge of the indigenous placenta disposal was discovered from the data, although some of the midwives had no idea. It was also discovered that indigenous placenta disposal is regarded as a valuable practice that should be respected, and the legislature on indigenous placenta disposal should be recognised and acknowledged.

Conclusion
The findings have demonstrated the significance of understanding and appreciating the various indigenous placenta disposal methods,and the need to legislate the historical impact on its beliefs and practices. This paper has thus aimed to explore and describe the views of the midwives and traditional birth attendants/indigenous knowledge holders in the Tshwane district, Gauteng province, South Africa.
Improving Antioxidant Effect of Stemona tuberosa by Fermentation with Endophytic Fungus Penicillium expansum STRB13
Authors: Dong Jian-Wei , Li Xue-Jiao , Zhao Hui , Wang Xue-Xian 
Published: January 2025

Background:
Stemona tuberosa Lour. is a plant belonging to the genus Stemona
(Stemonaceae) that has been utilized in traditional Chinese medicine (TCM) for its antitussive and
antiparasitic properties. Endophytic fungi have been shown to play an important role in the growth
and metabolism of plants. Fermentation involving endophytic fungi tends to result in the production
of new or more potent pharmacological compounds.

Objective:
The study aims to enhance the antioxidant activity of S. tuberosa by fermenting it with a
symbiotic endophytic fungus.

Methods:
Seven symbiotic endophytic fungi were used to screen and ferment S. tuberosa to improve
antioxidant activity estimated by 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity
and ferric ion-reducing antioxidant power (FRAP). The chemical constituent changes were characterized
by ultraviolet (UV) spectrum and high-performance liquid chromatography (HPLC) analysis.

Results:
Penicillium expansum STRB13, an endophytic fungus associated with S. tuberosa, was
screened for its ability to enhance antioxidant capacity through fermentation. The fermentation of S.
tuberosa using P. expansum STRB13 significantly improved its DPPH radical scavenging activity,
achieving an IC50 value of 24.2 μg/mL. Additionally, the ferric reducing antioxidant power (FRAP)
of the fermented sample was fourteen times greater, measuring 388.1 ± 32.6 μmol/L compared to
27.5 ± 1.0 μmol/L in the blank sample. Differences observed between the blank and P. expansum
STRB13 fermented S. tuberosa (FST) in UV spectra and HPLC analysis indicated the production of
new aromatic phenolic compounds through fermentation, which contributed to the enhanced antioxidant
activity.

Conclusion:
This is the first time reporting on the fermentation processing of S. tuberosa with symbiotic
endophytic fungus. This study revealed that P. expansum STRB13 FST will be an alternative
natural antioxidant. Fermentation with symbiotic endophytic fungus is a new approach to processing
TCM and discovering new compounds.
Wind Power Prediction Based on The SENet-CNN-LSTM Model
Authors: Zhang Zhiyan , Zhang Xuefeng , Li Ke , Li Jianyong , Zhao Hailiang , Liu Hua 
Published: January 2025

aims:
To improve the accuracy of wind power prediction

background:
In recent years, wind power has developed rapidly nationwide and worldwide.How to improve the prediction precision and accuracy of wind power has become a research hotspot in this field

objective:
This paper aims to construct a wind power forecasting system based on SENet-CNN-LSTM to improve the accuracy and stability of wind power forecasting

method:
Firstly, the isolated forest algorithm is used to detect abnormal values in wind power historical data, and the linear interpolation method is used to fill in the missing data. Secondly, CNN is used to extract the spatio-temporal characteristics of wind power data, SENet is used to assign different weights to the extracted feature information, and LSTM’s unique gating mechanism is used to memorize and forget the information. Finally, taking the measured historical data of a wind power farm as the sample, six algorithms including CNN, LSTM, CNN-LSTM, SENet-CNN, SENet-LSTM and SENet-CNN-LSTM are used to predict the example

result:
The prediction results show that the RMSE, MAE and MAPE of SENet-CNN-LSTM are significantly reduced compared with the other five prediction models

conclusion:
The wind power prediction model based on SENet-CNN-LSTM has high prediction accuracy and good performance

other:
There is no.
Pervasive Games for Sexual Health Promotion: Scoping Literature Review
Authors: Rubio Claudio , Besoain Felipe 
Published: January 2025

Background
Serious games play a fundamental role in promoting safe sexual behaviors. This medium has great potential for promoting healthy behaviors that prevent potential risk factors, such as sexually transmitted infections, and promote adherence to sexual health treatments, such as antiretroviral therapy. The ubiquity of mobile devices enhances access to such tools, increasing the effectiveness of video games as agents of change.

Objective
In this scoping review, we aimed to (1) identify the extent to which pervasive games have been used in the field of sexual health, (2) determine the theories used in the design and evaluation of pervasive games for sexual health, (3) identify the methods used to evaluate pervasive games for sexual health, and (4) explore the reported benefits of using pervasive games for sexual health.

Methods
Following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) methodology, we conducted a comprehensive literature search in the Web of Science, Scopus, IEEE Xplore, and ACM databases for articles published between January 1, 2000, and August 4, 2024. Included articles were published in English between 2000 and 2024 and involved the design, implementation, or evaluation of a ubiquitous video game focused on promoting safe sexual behaviors, with qualitative and/or quantitative results based on theory-based techniques and ubiquitous technologies. Review articles, conference papers, or books without available data or quantitative or qualitative results were excluded.

Results
We screened 521 of 612 articles (85.1%) after removing duplicates. After the title and abstract review, 51 (9.8%) articles were assessed for eligibility, and 30 (5.8%) articles meeting the criteria were studied and evaluated in depth. The results suggested that the use of pervasive video games has a positive impact on promoting safe sexual behaviors. This is enhanced by the effectiveness of theory-based techniques and the use of mobile technologies as developmental factors that drive the gaming experience. The results indicated that this domain is a growing field that should not be ignored.

Conclusions
The literature showed that pervasive video games have been effective in promoting safe sexual behaviors. Substantial growth has been seen in scientific community interest in researching this domain; nevertheless, there is still much to work on. In this context, we advocate for the standardization of design, implementation, and experimentation as essential phases in creating video game experiences. These 3 fundamental aspects are critical in the development of video game–based studies to ensure the reproducibility of experiments.
Evaluation and Comparison of the Academic Quality of Open-Access Mega Journals and Authoritative Journals: Disruptive Innovation Evaluation
Authors: Jiang Yuyan , Liu Xue-li , Wang Liyun 
Published: January 2025

Background
Some scholars who are skeptical about open-access mega journals (OAMJs) have argued that low-quality papers are often difficult to publish in more prestigious and authoritative journals, and OAMJs may be their main destination.

Objective
This study aims to evaluate the academic quality of OAMJs and highlight their important role in clinical medicine. To achieve this aim, authoritative journals and representative OAMJs in this field were selected as research objects. The differences between the two were compared and analyzed in terms of their level of disruptive innovation. Additionally, this paper explored the countries and research directions for which OAMJs serve as publication channels for disruptive innovations.

Methods
In this study, the journal information, literature data, and open citation relationship data were sourced from Journal Citation Reports (JCR), Web of Science (WoS), InCites, and the OpenCitations Index of PubMed Open PMID-to-PMID citations (POCI). Then, we calculated the disruptive innovation level of the focus paper based on the local POCI database.

Results
The mean Journal Disruption Index (JDI) values for the selected authoritative journals and OAMJs were 0.5866 (SD 0.26933) and 0.0255 (SD 0.01689), respectively, showing a significant difference. Only 1.48% (861/58,181) of the OAMJ papers reached the median level of disruptive innovation of authoritative journal papers (MDAJ). However, the absolute number was roughly equal to that of authoritative journals. OAMJs surpassed authoritative journals in publishing innovative papers in 24 research directions (eg, Allergy), accounting for 40.68% of all research directions in clinical medicine. Among research topics with at least 10 authoritative papers, OAMJs matched or exceeded MDAJ in 35.71% of cases. The number of papers published in authoritative journals and the average level of disruptive innovation in each country showed a linear relationship after logarithmic treatment, with a correlation coefficient of –0.891 (P<.001). However, the number of papers published in OAMJs in each country and the average level of disruptive innovation did not show a linear relationship after logarithmic treatment.

Conclusions
While the average disruptive innovation level of papers published by OAMJs is significantly lower than that of authoritative journals, OAMJs have become an important publication channel for innovative research in various research directions. They also provide fairer opportunities for the publication of innovative results from limited-income countries. Therefore, the academic community should recognize the contribution and value of OAMJs to advancing scientific research.