bluuebunny/crossref_metadata_2025_split huggingface dataset:
α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease
Authors: Martin-Lopez Eduardo , Vidyadhara D. J. , Liberia Teresa , Meller Sarah J. , Harmon Leah E. , Hsu Ryan M. , Spence Natalie , Brennan Bowen , Han Kimberly , Yücel Betül , Chandra Sreeganga S. , Greer Charles A. 
Published: January 2023

Parkinson's disease (PD) is characterized by multiple symptoms including olfactory dysfunction, whose underlying mechanisms remain unclear. Here, we explored pathologic changes in the olfactory pathway of transgenic (Tg) mice of both sexes expressing the human A30P mutant α-synuclein (α-syn; α-syn-Tg mice) at 6–7 and 12–14 months of age, representing early and late-stages of motor progression, respectively. α-Syn-Tg mice at late stages exhibited olfactory behavioral deficits, which correlated with severe α-syn pathology in projection neurons (PNs) of the olfactory pathway. In parallel, olfactory bulb (OB) neurogenesis in α-syn-Tg mice was reduced in the OB granule cells at six to seven months and OB periglomerular cells at 12–14 months, respectively, both of which could contribute to olfactory dysfunction. Proteomic analyses showed a disruption in endocytic and exocytic pathways in the OB during the early stages which appeared exacerbated at the synaptic terminals when the mice developed olfactory deficits at 12–14 months. Our data suggest that (1) the α-syn-Tg mice recapitulate the olfactory functional deficits seen in PD; (2) olfactory structures exhibit spatiotemporal disparities for vulnerability to α-syn pathology; (3) α-syn pathology is restricted to projection neurons in the olfactory pathway; (4) neurogenesis in adult α-syn-Tg mice is reduced in the OB; and (5) synaptic endocytosis and exocytosis defects in the OB may further explain olfactory deficits.SIGNIFICANCE STATEMENTOlfactory dysfunction is a characteristic symptom of Parkinson's disease (PD). Using the human A30P mutant α-synuclein (α-syn)-expressing mouse model, we demonstrated the appearance of olfactory deficits at late stages of the disease, which was accompanied by the accumulation of α-syn pathology in projection neurons (PNs) of the olfactory system. This dysfunction included a reduction in olfactory bulb (OB) neurogenesis as well as changes in synaptic vesicular transport affecting synaptic function, both of which are likely contributing to olfactory behavioral deficits.
Exploring a surrogate of Pellet–Cladding interaction: Characterization and oxidation behavior
Authors: Rodríguez-Villagra N. , Bonales L. J. , Fernández-Carretero S. , Milena-Pérez A. , Gutierrez L. , Galán H. 
Published: January 2023

AbstractThe present work analyzes the effect of different Zr contents on the microstructure and thermal behavior of non-irradiated UO2. A set of Zr-doped UO2 (0, 20, 40, 80, and 100 wt%) pellets was prepared via solid-state synthesis by mimicking the chemical bonding between ZrO2 and UO2. After sintering, the Zr-doped UO2 monoliths were characterized by scanning electron microscopy, Raman spectroscopy, and X-ray diffraction. Oxidation of the Zr-doped UO2 samples has been monitored by thermogravimetric analysis. Results of thermal behavior under air and low oxygen partial pressure show a profound effect of delayed oxidation with the addition of Zr to UO2 and then an increased oxidation resistance of UO2 to U3O8 when compared to pure UO2 pellet.
Graphical abstract
KOMPOSISI HASIL TANGKAPAN HAND LINE DI PPS CILACAP
Authors: Saputra Aman , Saputra Reza , Nurlaela Eli 
Published: January 2023

Tujuan dilaksanakannya penelitian ini adalah untuk mengetahui komposisi hasil tangkapan hand line di PPS Cilacap pada KM. Colombia 2. Komposisi berupa jenis dan jumlah ikan yang ditangkap menggunakan alat penangkapan ikan hand line yang didaratkan di PPS Cilacap pada tahun 2021. Metode analisis data yang dilakukan dalam menghitung komposisi dari jenis hasil tangkapan hand line diperoleh berdasarkan komposisi setiap bulan. Berdasarkan hasil penelitian diperoleh kesimpulan bahwa Komposisi ikan hasil tangkapan hand line pada KM. Colombia 2 yang ditangkap di Samudera Hindia tepatnya WPP 573 dan didaratkan di PPS Cilacap didominasi oleh ikan cakalang, ikan tuna dan cumi-cumi. Pada tahun 2021, hasil tangkapan tertinggi ada di Bulan Oktober sebesar 29,66% dan terendah terdapat pada Bulan Januari sebesar 9,87%.
POTENSI DAN PEMANFAATAN HIU DI WPPNRI 717 KHUSUSNYA DI PERAIRAN KABUPATEN BIAK NUMFOR
Authors: Wardono Suko , Widiarto Santoso Budi , Ramadhan Achmad Rifqy , Sombo Hendrik 
Published: January 2023

Aktifitas penangkapan hiu yang semakin marak dipicu oleh tingginya permintaan pasar terhadap komoditas produk hiu khususnya produk sirip, hiu biasanya menjadi tangkapan target maupun tangkapan sampingan bagi nelayan. Meningkatnya produksi tangkapan di Sentra Kelautan dan Perikanan Terpadu (SKPT) Biak Numfor, menjadi tantangan tersediri dalam pengelolaan penangkapan hiu di WPPNRI 717 khususnya di perairan Kabupaten Biak Numfor. Penelitian ini dimaksudkan untuk mengidentifikasi potensi perikanan hiu dengan menggunakan metode observer on board atau pengamatan secara langsung di atas kapal penangkapan ikan dengan pancing rawai hanyut. Observasi meliputi pencatatan jumlah tangkapan harian, jenis ikan, morfometrik (panjang total, panjang baku, panjang klasper dan berat), dan data harian GPS kapal. Hasil Penelitian menunjukkan bahwa selama enam bulan diperoleh akumulasi luas area penangkapan sekitar 23.335 km2. Ditemukan dua jenis hiu Appendiks II CITES yakni Carcharhinus falciformis sebanyak 1.513 ekor dan Sphyrna lewini 5 Ekor, serta dua jenis Non Appendiks CITES yakni Carcharhinus brevipinna 21 Ekor dan Carcharhinus amblyrhynchos 88 ekor. Panjang total hiu secara umum berkisar antara 140 – 234 cm dengan berat 35 – 66 kg. Sampling pengukuran panjang total pada jenis Carcharhinus falciformis menunjukkan bahwa 75,6% hiu yang tertangkap telah mencapai kematangan seksual. Data perdagangan produk sirip yang dilalulintaskan dari Kabupaten Biak Numfor berjumlah total 2.868,5 kg, dengan produk hiu Non Appendiks CITES terbanyak jenis Carcharhinus amblyrhynchos sebanyak 910 kg dan produk Hiu Appendiks II CITES terbanyak jenis Carcharhinus falciformis sebanyak 795,5 kg.
Caracterización genética de aislamientos de <i>Phytophthora infestans</i> en las zonas productoras de papa de los departamentos de Antioquia, Boyacá, Cundinamarca y Norte de Santander (Colombia)
Authors: Silva Bernardo , Jaramillo Sonia , Marín Mauricio 
Published: January 2023

El tizón tardío ó gota de la papa, causada por el Oomycete Phytophthora infestans, es la enfermedad más limitante de este cultivo en el mundo. En Colombia, la gota presenta niveles altos de incidencia y severidad en la mayor parte de las regiones productoras de papa, siendo frecuente encontrar cultivos en los cuales toma proporciones epidémicas, causando la pérdida total de la producción cuando no se aplican frecuentemente fungicidas. El conocimiento de las características genotípicas de los ftopatógenos es una condición fundamental para el diseño y aplicación de métodos de control de las enfermedades causadas por éstos. En la presente investigación se evaluaron los haplotipos mitocondriales, tipo de apareamiento y el nivel de variación de las regiones ITS y 28S del ADN ribosomal de poblaciones de 40 aislamientos de P. infestans obtenidos de cultivos de papa en los departamentos de Antioquia, Boyacá, Cundinamarca y Norte de Santander (Colombia). Los resultados indicaron la presencia de un sólo haplotipo mitocondrial (IIa) y el tipo de apareamiento A1 en todos los aislamientos de las cuatro poblaciones evaluadas, lo que sugiere la ocurrencia de un solo linaje genético (posiblemente EC-1) del patógeno en los cultivos de papa de las zonas estudiadas. De otra parte, las secuencias de las regiones ITS y 28S fueron idénticas para todoslos aislamientos y presentaron altos niveles de identidad con aislamientos de otros hospedantes y regiones del mundo. Estos resultados permiten inferir que en los cuatro departamentos las poblaciones de P. infestans presentan un comportamiento clonal y que no existe evidencia de su reproducción sexual.
Bond Graph Modeling, Simulation, and Control of Permanent Magnet Linear Synchronous Motor
Authors: Babangida Aminu , Husi Géza , Szemes Péter 
Published: January 2023

The high-performance feature of the Permanent Magnet Linear Synchronous Motor (PMLSM) makes it a reliable and valuable motor for use in the automotive industry, especially for electric vehicle (EVs) applications. This research proposes a bond graph approach in modeling the PMLSM as a multi-domain dynamical system.
However, A time-based simulation was performed using 20-sim software to simulate the dynamical behavior of the motor. An equivalent model of the motor was first obtained and then modeled and simulated using 20-sim software. The model of the PMLSM drive system was modeled separately and incorporated with PMLSM Motor equivalent model to form a global model.
Moreover, the motor drive system response was studied based on the sensor resolutions and the inverter switching frequency. The block diagram and the transfer function methods validated the bond graph model obtained. Two classical PIs such as continuous and discrete were implemented on the motor response to control the velocity of the motor.
Source character of microseismicity in the San Francisco Bay block, California, and implications for seismic hazard
Authors: Olson Jean A. , Zoback Mary Lou 
Published: January 2023

Abstract
We examine relocated seismicity within a 30-km-wide crustal block containing San Francisco Bay and bounded by two major right-lateral strike-slip fault systems, the Hayward and San Andreas faults, to determine seismicity distribution, source character, and possible relationship to proposed faults. Well-located low-level seismicity (Md ≦ 3.0) has occurred persistently within this block throughout the recording interval (1969 to 1995), with the highest levels of activity occurring along or directly adjacent to (within ∼5 km) the bounding faults and falling off toward the long axis of the bay. The total seismic moment release within the interior of the Bay block since 1969 is equivalent to one ML 3.8 earthquake, one to two orders of magnitude lower than activity along and within 5 km of the bounding faults. Focal depths of reliably located events within the Bay block are generally less than 13 km with most seismicity in the depth range of 7 to 12 km, similar to focal depths along both the adjacent portions of the San Andreas and Hayward faults. Focal mechanisms for Md 2 to 3 events within the Bay block mimic focal mechanisms along the adjacent San Andreas fault zone and in the East Bay, suggesting that Bay block is responding to a similar regional stress field. Two potential seismic source zones have been suggested within the Bay block. Our hypocentral depths and focal mechanisms suggest that a proposed subhorizontal detachment fault 15 to 18 km beneath the Bay is not seismically active. Several large-scale linear NW-trending aeromagnetic anomalies within the Bay block were previously suggested to represent large through-going subvertical fault zones. The two largest earthquakes (both Md 3.0) in the Bay block since 1969 occur near two of these large-scale linear aeromagnetic anomalies; both have subvertical nodal planes with right-lateral slip subparallel to the magnetic anomalies, suggesting that structures related to the anomalies may be capable of brittle failure. Geodetic, focal mechanism and seismicity data all suggest the Bay block is responding elastically to the same regional stresses affecting the bounding faults; however, continuous Holocene reflectors across the proposed fault zones suggest that if the magnetic anomalies represent basement fault zones, then these faults must have recurrence times one to several orders of magnitude longer than on the bounding faults.
Estimation of source parameters and Q from acceleration recorded in the Vatnafjöll earthquake in south Iceland
Authors: Ólafsson Símon , Sigbjörnsson Ragnar , Einarsson Páll 
Published: January 2023

Abstract
The earthquake in Vatnafjöll, 25 May 1987 (M = 5.8), was the largest earthquake in south Iceland since 1912 (M = 7), and it was one of the first earthquakes recorded on a local network of strong-motion acceleration recorders. In this study, the strong-motion records are used to obtain an estimate of the source parameters and the attenuation of high-frequency waves. The source parameters are obtained by fitting the data by a dislocation source model combined with an exponential model for the attenuation. The root-mean-squared acceleration is also estimated and compared to predicted values using the source parameters. The source parameters estimated here (M0 = 8.2 × 1024 dyn-cm, r = 4.6 km, Δσ = 38 bars, Δu = 36 cm, Td = 3 sec) and estimated moment magnitude (Mw = 5.9) agree well with values obtained previously from teleseismic waves and strain-meter data. Estimates of path-averaged crustal shear-wave quality factors give results in the range Q = 128 to 425, and k = 0.05 sec for the spectral decay parameter, confirming recent measurements of higher crustal Q for this region than in earlier studies.
On the mechanism of conversion of seismic waves to and fromTwaves in the vicinity of island shores
Authors: Talandier Jacques , Okal Emile A. 
Published: January 2023

AbstractHigh-frequency seismic records from the Polynesian Seismic Network are used to investigate in detail the processes of conversion of acoustic (T-wave) energy from and to seismic waves at island shores. On the source side, we study the seismic-to-acoustic conversion based on T phases from Hawaiian events recorded at Polynesian stations located on the coral platter; on the receiver side, we study the acoustic-to-seismic conversion based on T phases from marine sources recorded across the Polynesian islands. In both instances, our results underline the importance of steep slopes (typically 50°) in allowing an efficient conversion between P waves in the island structure and T waves in the water column. These slopes can be coral reefs or the heads of young, presumably unconsolidated, basalt flows. Under this geometry, modeling based on raytracing indicates that the seismic record of the T phase consists of a P wave at distances from the conversion point greater than 9 km; at shorter distances, S waves and surface waves are generated. In the absence of a steep slope, only surface waves are present. These models can be used to compute precise and predictable travel-time station corrections, allowing the use of seismometers located inland to exploit the superb detection and location capabilities of T waves.
IMPLIKATUR PERCAKAPAN PADA TRANSAKSI JUAL BELI DI PASAR PAGI SAMARINDA: KAJIAN PRAGMATIK
Authors: Sartika Sari  
Published: January 2023

Tujuan penelitian ini untuk mendeskripsikan implikatur percakapan dalam transaksi jual beli yang digunakan di Pasar Pagi. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Sumber data dari bahasa lisan yang dituturkan penjual dan pembeli dalam kegiatan transaksi jual beli. Teknik dalam pengumpulan data yang digunakan yakni teknik rekam dan simak catat. Tahap analisis data dilakukan dengan menemukan bentuk implikatur percakapan yang sering digunakan antara penjual dan pembeli dalam transaksi jual beli. Setelah dilakukan penelitian, bentuk implikatur percakapan yang mendominasi dalam tuturan antara penjual dan pembeli dalam transaksi jual beli di Pasar Pagi Kecamatan Samarinda Kota, Kota Samarinda. Ditemukan bahwa bentuk implikatur percakapan yang digunakan adalah implikatur kalimat berita, kalimat tanya, dan kalimat perintah.
TREN BISNIS & PENERAPAN PRINSIP SYARIAH PADA INDUSTRI PERHOTELAN PARIWISATA HALAL DI INDONESIA
Authors: Ayatina Haerini , Astuti Fakhriyah Tri , Makfi Muhammad miqdam 
Published: January 2023

Tulisan ini membahas tentang pertumbuhan ekonomi Indonesia berbasis wisata halal. Meningkatnya kunjungan wisatawan muslim dunia terhadap industri pariwisata Indonesia. Terkhusus lagi geliat bisnis hotel syariah, kebutuhan akan halal-friendly hotels semakin meningkat. Sehingga permintaan akan pelayanan hotel syariah di indonesia akan semakin meningkat pula. Maka melihat tren positif bisnis hotel syariah ini, peluang besar bagi negara indonesia untuk menggarap secara serius peluang bisnis ini dan memberikan perhatian lebih pada bisnis hotel syariah. Topik ini akan dianalisis menggunakan metode kualitatif dengan penalaran deduktif. Data primer didapatkan melalui analisis teks laporan Global Travel Muslim Index (GMTI), lembaga negara yang bertugas mengembangkan sektor pariwisata, dan bertanggungjawab pada sertifikasi halal. Data sekunder didapatkan dari telaah pustaka yang bersumber dari literatur penelitian yang merujuk pada pembangunan sektor pariwisata. Hasil menunjukkan Kinerja Indonesia yang terus mengelaola wisata halal akhirnya berbuah manis. April 2019, akhirnya Indonesia ditetapkan peringkat pertama sebagai tujuan wisata halal terbaik di dunia bersama dengan Malaysia. Tentunya ini merupakan hasil kerja keras dari masyarakat, pemerintah serta pelaku wisata di Indonesia. Harapannya dengan pengembangan wista halal ini dapat memperkuat perekonomian masyarakat dan negara Indonesia.
Praksis Penanaman Nilai Local Wisdom Masyarakat Desa Jrahi sebagai Learning Resources IPS
Authors: Karim Abdul 
Published: January 2023

<p><strong><span lang="EN-US">The Practice of Instilling Local Wisdom Values for the </span><span>Jrahi Village </span><span lang="EN-US">Community as Learning Resources</span><span>of </span><span lang="EN-US">Social Studies</span><span>. </span></strong><span lang="EN-US">Research with locus in Jrahi Village, </span><span lang="EN-US">Gunungwungkal District, Pati Regency, aims to: 1) analyze the praxis of the value of local wisdom of the people of Jrahi Village; 2) assessing the value of local wisdom of the community as a source of social studies learning. The approach in this study is Participatory Action Research – a participatory action research method aimed at identifying research problems based on the needs of the research subject. Researchers as interventionists, activists, and facilitators. The collected data are analyzed qualitatively. The results showed: 1) The praxis of the value of local wisdom of the people of Jrahi Village – such as Sedekah Bumi, Ngalungi Sapi, Barikan, and Dawuhan – became local wisdom that was preserved; 2) The values of local wisdom of the community as a source of social studies learning with the stages of formulating goals, determining material, and making appropriate learning strategies. </span></p><p><span lang="EN-US"><br /></span></p><p><span lang="EN-US"><span>Penelitian dengan lokus di Desa Jrahi Kecamatan Gunungwungkal Kabupaten </span><span lang="EN-US">Pati</span><span>, bertujuan untuk: 1) menganalisis praksis nilai kearifan lokal masyarakat Desa Jrahi; 2) mengkaji nilai kearifan lokal masyarakat sebagai sumber pembelajaran IPS. </span><span>Pendekatan dalam penelitian ini adalah <em>Participatory Action Research</em> –metode penelitian aksi partisipatoris bertujuan mengidentifikasi problem penelitian berdasar pada kebutuhan dari subjek penelitian. Peneliti sebagai <em>interventionist</em>, aktivis, dan fasilitator. Data yang dikumpulkan dianalisis secara kualitatif. Hasil penelitian menunjukkan: 1) Praksis nilai kearifan lokal masyarakat Desa Jrahi –seperti <em>Sedekah Bumi</em>, <em>Ngalungi Sapi</em>, <em>Barikan</em>, dan <em>Dawuhan</em>– menjadi kearifan lokal yang dilestarikan; 2) Nilai-nilai kearifan lokal masyarakat sebagai sumber pembelajaran IPS dengan tahapan merumuskan tujuan, menentukan materi, dan membuat strategi pembelajaran yang tepat. </span></span></p>
Teori Belajar Humanistik dalam Pembelajaran Matematika SD
Authors: Alkhasanah Nuraini , Wahyuni Sri , Fauziati Endang 
Published: January 2023

Artikel ini merupakan sebuah kajian literatur tentang teori belajar humanistik dalam pembelajaran matematika SD. Konsep belajar yang diusung humanistik adalah memanusiakan manusia, dan lebih menekankan proses daripada hasil belajar. Teori humanistik pada dasarnya konsep belajar yang memberikan penjelasan tentang bagaimana memanusiakan siswa dan mengaktualisasikan semua kemampuan potensi-potensi setiap peserta didik untuk meghadapi perubahan lingkungan disekitarnya. Teori ini mengasumsikan belajar tidak akan bermakna jika ada paksaan didalamnya. Dalam kajian ini membahas tentang: (1) apa itu teori belajar humanistik? (2) Apa itu pembelajaran matematika SD? (3) Bagaimana pembelajaran matematika berbasis teori belajar humanistik?
WITHDRAWN: Contamination Analysis of Coal Ash and Treated Marine Clay
Authors: Jamaludin Nadiah , Yunus Nor Zurairahetty Mohd , Jusoh Siti Norafida , Zolkepli Muhammad Farhan , Mohammed Ahmed Mohammed Awad 
Published: January 2023

Abstract

The production of coal ash waste is rising alongside the need for power. Therefore, it is necessary to reuse coal ash waste. However, it is unclear if coal ash is genuinely safe for the environment. In this study, coal ash waste and treated marine clay will be subjected to toxicity characteristic leaching to determine the ground contamination caused by coal ash, cement, and marine clay stabilisation. Using the US Department of Environmental (DoE) standard, all three samples of bottom ash, fly ash and treated marine clay (15% 50BA:50FA) showed values below DoE regulatory limits, with the treated sample having the lowest. Using the Malaysian Water Standard, it was determined that the quantities of Cd, Se, and Ag in all three samples were within the regulatory limits established by the Malaysian Water Standard. Except for Cr and Hg, the concentrations of elements identified in the treated 15% 50BA:50FA sample were all within regulatory limits. In descending order, the trend of heavy metal leaching was Ba > Hg > Cr > As > Pb > Ag > Cd > Se, with Ba leaching the most. According to the U.S. Department of Environmental Protection, coal ash and stabilised marine clay are deemed environmentally safe (DoE). For the Malaysian Water Standard, however, water leached from treated marine clays could not be consumed directly. It must be processed before being supplied to consumers.