bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concepts of good mental health and wellbeing in people with intellectual disability: Study protocol for a systematic review
Authors: Komenda Sophie , Brunevskaya Nadine , Moritz Paula , Landskron Sarah Jasmin , Zrnic Novakovic Irina , Oberleiter Sandra , Wurzer Jana , Lueger-Schuster Brigitte , Salvador-Carulla Luis , Zeilinger Elisabeth L. 
Published: April 2023

IntroductionGood mental health is an indispensable aspect of good general health and different definitions of good mental health have been developed for the general population. However, it is not clear how these definitions can be applied to people with intellectual disabilities (ID), as they may have difficulties in many facets encompassed in existing definitions. Yet, people with ID can be mentally healthy or mentally ill just as people without ID.ObjectiveThe aim of this systematic review is to summarize existing concepts, definitions, and measurement approaches of good mental health and wellbeing for people with ID.MethodsA comprehensive, systematic literature review will be conducted in 11 databases, including ASSIA, CINAHL, Cochrane Library, ERIC, MedRxiv, OSF preprints, ProQuest Dissertations &amp; Theses Global, PsycINFO, PubMed, Scopus, and Web of Science. By including preprints and theses servers in the search strategy, we will also consider grey and unpublished literature. The quality of included studies will be rated using standardized checklists. All steps of the literature search, data extraction, and quality rating will be performed independently by two trained researchers. Disagreements will be resolved through discussion between these researchers and, if required, by consulting a third team member. In a narrative synthesis, existing approaches to good mental health and wellbeing for people with ID will be systematically described and linked to current research in mental health for people with and without ID.DiscussionThe findings of this study will provide researchers and practitioners with an evidence-based overview of current approaches to good mental health and wellbeing of people with ID. We will explore and discuss the individual facets of the definitions, concepts, and measurement approaches and identify possible gaps which need to be addressed. This will strengthen future research on this topic and focus research activities on important and unresolved themes that need to be targeted to promote health equity for people with ID.
Prevalence of pulmonary tuberculosis in homeless individuals in the Addis Ababa City, Ethiopia
Authors: Shamebo Tsegaye , Mekesha Sindew , Getahun Muluwork , Gumi Balako , Petros Beyene , Ameni Gobena 
Published: April 2023

BackgroundHomeless individuals are at a high risk of infection with Mycobacterium tuberculosis (M. tuberculosis) as compared to the general population. The number of homeless individuals has been increasing in Addis Ababa City during the last three decades due to the migration of rural inhabitants to the City for better living conditions. The objective of this study was to estimate the prevalence of pulmonary tuberculosis (PTB) and evaluate associated risk factors in homeless individuals in Addis Ababa City.MethodsA total of 5,600 homeless individuals were screened for PTB symptoms using WHO guideline between February 2019 and December 2020. Sputum samples were cultured from individuals with symptoms of PTB for mycobacterial isolation. Logistic regression analysis was used to identify factors associated with PTB.ResultsThe prevalence of bacteriologically confirmed cases was 1.1% (59/5,600) or 10.54 per 1000 population. Multinomial logistic regression analysis showed that being homeless for more than 5 years, body mass index (BMI) &lt; 18.5, smoking cigarette, living in a group of more than five individuals, close contact with chronic coughers, imprisonment and HIV infection were significantly associated with the prevalence of PTB in homeless individuals (P &lt; 0.05).ConclusionIn conclusion, the result of this study indicated that the prevalence of PTB in homeless individuals was higher than the prevalence of PTB in the general population of Addis Ababa City requiring for the inclusion of the homeless individuals in the TB control program.
Understanding factors influencing home pregnancy test use among women in western Kenya: A qualitative analysis
Authors: Mazumder Christina , Dollah Annabel , Ouda Rosebel , Okombo Moses , Nyakina Judith , Makia Monica L. , Dettinger Julia C. , Gómez Laurén , Marwa Mary , Ochieng Ben , Abuna Felix , Gwayi-Chore Claire , Pintye Jillian , Kinuthia John , John-Stewart Grace , Pfeiffer James , Mugambi Melissa L. 
Published: April 2023

BackgroundThere are limited data on home pregnancy test use among women in low-and-middle-income countries. A prior survey found that only 20% of women in western Kenya used a home pregnancy test to confirm their pregnancies before going to antenatal care. This qualitative study aims to understand why women do not use home pregnancy tests in early pregnancy.MethodsFrom April 2021 to July 2021, we interviewed women from four antenatal care clinics in Homa Bay and Siaya counties. We recruited women previously enrolled in the PrEP Implementation for Mothers in Antenatal care (PrIMA) study, a cluster-randomized trial that evaluated the best approaches to implementing PrEP in maternal and child health clinics in Western Kenya (NCT03070600). Interviews were conducted via phone, audio recorded, translated, and transcribed verbatim. We coded and analyzed the transcripts to capture factors influencing women's capability, opportunity, and motivation to use home pregnancy tests.ResultsWe conducted 48 semistructured interviews with women aged 21–42 years. Twenty-seven women did not use a home pregnancy test in their most recent pregnancy. Seventeen of these women reported not using a home pregnancy test before. Lack of knowledge, mistrust in the accuracy of tests, preferring to rely on signs and symptoms of pregnancy or get a test from the health facility, cost, and accessibility were key barriers to home pregnancy test use.ConclusionImproving the uptake of home pregnancy testing during early pregnancy will require efforts to enhance community knowledge of test use and associated benefits and reduce cost burdens by making tests more affordable and accessible.
A new nursing pattern based on ERAS concept for patients with lumbar degenerative diseases treated with OLIF surgery: A retrospective study
Authors: Lu Hai-rong , Yang Ao , Li Xu , He Meng-zi , Sun Jia-yuan 
Published: April 2023

ObjectiveThe purpose of this study was to introduce enhanced recovery after surgery (ERAS) concept into patients with lumbar degenerative diseases who were treated with oblique lumbar interbody fusion (OLIF), and to assess whether it could increase clinical efficacy, reduce perioperative complications, shorten length of hospital stay (LHS), decrease readmission rate, and improve patient satisfaction.MethodsThe study included patients with lumbar degenerative diseases (LDDs) who underwent OLIF between July 2017 and October 2018 (non-ERAS group), and between November 2018 and July 2020 (ERAS group). The two groups were compared according to the demographic and clinical characteristics.ResultsThere was no significant difference in descriptive characteristics and concomitant diseases between the two groups. The preoperative Oswestry disability index (ODI) score (P = 0.191), lumbar visual analogue scale (VAS) score (P = 0.470), and leg VAS score (P = 0.657) did not significantly different. Most of the ERAS measures were also well implemented after surgery, except for early delivery (74.2%), early catheter removal (63.9%), and multimodal analgesia (80.6%). The LHS in the ERAS group was significantly shorter than that in the non-ERAS group (P = 0.004). Besides, Hamilton Anxiety Rating Scale (HAMA) score at 3 days after surgery showed a significant difference between the two groups (P = 0.019). The patient satisfaction in ERAS group was significantly higher than that in the non-ERAS group (P = 0.001).ConclusionThe new nursing pattern combined with ERAS in patients with LDDs who underwent OLIF did not improve the short-term prognosis of surgery, while it could effectively reduce postoperative complications, shorten the LHS, and improve patient satisfaction, and did not lead to additional adverse events.
Canine adipose tissue-derived MSCs engineered with mRNA to overexpress TSG-6 and enhance the anti-inflammatory effects in canine macrophages
Authors: Yun Ga-Hee , Park Su-Min , Lim Ga-Hyun , Seo Kyoung-Won , Youn Hwa-Young 
Published: April 2023

BackgroundMesenchymal stem cells (MSCs) are useful agents in the treatment of various inflammatory diseases. The immunomodulatory effects of MSCs are largely related to their secretory properties. mRNA engineering emerged as a safe alternative to enhance the secretory function of MSCs. Optimization of the untranslated region (UTR) sequence is important for enhancing the translational efficiency of exogenous mRNAs. However, research on the optimization of UTR in canine MSCs has not yet been conducted.ObjectivesWe aimed to identify the UTR sequence related to the expression efficiency of in vitro transcription (IVT) mRNA in canine MSCs and investigate whether mRNA-engineered MSCs that overexpress TSG-6 exhibit enhanced anti-inflammatory effects.MethodsCanine adipose tissue-derived (cAT)-MSCs were transfected with green fluorescence protein (GFP) mRNA with three different UTRs: canine hemoglobin subunit alpha-like 1 (HBA1), HBA2, and hemoglobin subunit beta-like (HBB). The translation efficacy of each mRNA was evaluated using relative fluorescence. TSG-6 mRNA was produced with the UTR optimized according to relative fluorescence results. cAT-MSCs were transfected with TSG-6 mRNA (MSCTSG-6), and TSG-6 expression was analyzed using real-time quantitative PCR, ELISA, and western blotting. To evaluate the anti-inflammatory effects of MSCsTSG-6, DH82 cells were co-cultured with MSCsTSG-6 or treated with dexamethasone, and changes in the expression of inflammatory cytokines were analyzed using qPCR.ResultsThe highest fluorescence level was observed in the HBA1 UTR at 24 h post-transfection. TSG-6 mRNA transfection yielded high levels of TSG-6 in the cAT-MSCs. In DH82 cells co-cultured with MSCsTSG-6, the expression of inflammatory cytokines decreased compared to that in co-culturing with naïve MSCs and dexamethasone treatment.ConclusionsOptimization of the HBA1 UTR improved the translation efficiency of IVT mRNA in canine MSCs. cAT-MSCs engineered with TSG-6 mRNA effectively enhanced the anti-inflammatory effects of the MSCs when co-cultured with LPS-activated DH82 cells.
Case report: Low dose dexmedetomidine infusion for the management of hypoglycemia in a dog with an insulinoma
Authors: Green Randolph , Musulin Sarah E. , Baja Alexie Jade , Hansen Bernie D. 
Published: April 2023

ObjectiveTo describe the use of a low dose dexmedetomidine infusion as preoperative treatment for hypoglycemia secondary to a functional pancreatic tumor in a dog.Case summaryAn 8.7-year-old castrated male Hungarian Vizsla presented for further evaluation of persistent hypoglycemia after the referring veterinarian established a tentative diagnosis of insulinoma based on paired insulin and glucose measurements. Abdominal ultrasound and computed tomography demonstrated evidence of a pancreatic mass with possible hepatic metastases. Attempts to aspirate the lesions under ultrasound guidance were unsuccessful, and the dog was hospitalized overnight for planned surgical resection of the presumed pancreatic tumor and biopsy of the hepatic lesions the following day. In response to a progressive increase in patient anxiety and agitation trazodone was prescribed ~5 mg/kg orally every 8 h and gabapentin at ~7 mg/kg every 8 h. As the dog continued to remain anxious dexmedetomidine at a dose of 1 mcg/kg was administered intravenously immediately followed with an infusion of dexmedetomidine at 1 mcg/kg/h. The anxious behaviors were successfully controlled with minimal cardiovascular side effects. Serial blood glucose measurements obtained during this time demonstrated euglycemia. The dog remained euglycemic while receiving dexmedetomidine for the remainder of the pre-operative period and for duration of hospitalization following surgical resection and biopsy.New or unique information providedThis case report demonstrates a possible role for dexmedetomidine to counteract hypoglycemia in dogs with insulinomas.
Diversity of Pholcus Spiders (Araneae: Pholcidae) in China’s Lüliang Mountains: An Integrated Morphological and Molecular Approach
Authors: Zhao Fang-Yu , Yang Lan , Zou Quan-Xuan , Ali Abid , Li Shu-Qiang , Yao Zhi-Yuan 
Published: April 2023

Spiders of the genus Pholcus were collected for the first time during an expedition to the Lüliang Mountains in Shanxi Province, North China. Phylogenetic analyses of DNA sequence data from COI, H3, wnt, and 28S genes allowed us to group them into nine well-supported clades. We used morphology and four methods of molecular species delimitation, namely Automatic Barcode Gap Discovery (ABGD), the Generalized Mixed Yule Coalescent (GMYC), Bayesian Poisson Tree Processes (bPTP), and Bayesian Phylogenetics and Phylogeography (BPP), to investigate species boundaries. These integrative taxonomic analyses identified the nine clades as nine distinct species, comprising Pholcus luya Peng & Zhang, 2013 and eight other species new to science: Pholcus jiaocheng sp. nov., Pholcus linfen sp. nov., Pholcus lishi sp. nov., Pholcus luliang sp. nov., Pholcus wenshui sp. nov., Pholcus xiangfen sp. nov., Pholcus xuanzhong sp. nov., and Pholcus zhongyang sp. nov. The species occur in geographic proximity and show many morphological similarities. All of them belong to the P. phungiformes species group. The records from the Lüliang Mountains represent the westernmost distribution limit of this species group.
Comprehensive Investigation Illustrates the Role of M2 Macrophages and Its Related Genes in Pancreatic Cancer
Authors: Zhang Danying , Tang Wenqing , Shen Xizhong , Weng Shuqiang , Dong Ling 
Published: April 2023

Background and Objectives: M2 macrophages play an important role in cancers. Our study aimed to illustrate the effect of M2 macrophages in pancreatic cancer (PC). Materials and Methods: The open-access data used for analysis were downloaded from The Cancer Genome Atlas Program database, as well as some online databases. R software was mainly used for data analysis based on the specific packages. Results: Here, we comprehensively investigated the role of M2 macrophages and their related genes in PC. We performed the biological enrichment of M2 macrophages in PC. Meanwhile, we identified adenosine A3 receptor (TMIGD3) as the interest gene for further analysis. The single-cell analysis showed that was mainly expressed in the Mono/Macro cells based on the data from multiple data cohorts. Biological investigation showed that TMIGD3 was primarily enriched in angiogenesis, pancreas-beta cells and TGF-beta signaling. Tumor microenvironment analysis indicated that TMIGD3 was positively correlated with monocyte_MCPCOUNTER, NK cell_MCPCOUNTER, macrophages M2_CIBERSORT, macrophage_EPIC, neutrophil_TIMER and endothelial cell_MCPCOUNTER. Interestingly, we determined that all the immune functions quantified by single sample gene set enrichment analysis algorithms were activated in the patients with high TMIGD3 expression. Conclusions: Our results provide a novel direction for the research focused on the M2 macrophages in PC. Meanwhile, TMIGD3 was identified as an M2 macrophage-related biomarker for PC.
Study on the Expansion Kinetics of Plasma and Absorption Wave Induced by Millisecond-Nanosecond Combined Pulse Lasers in Fused Quartz
Authors: Geng Congrui , Cai Jixing , Liu Yubo , Zhang Zequn , Mao Hongtao , Yu Hao , Wang Yunpeng 
Published: April 2023

The transient temperature field, the velocity and pressure of plasma, and the absorption wave of fused quartz induced by millisecond-nanosecond combined pulse lasers are simulated. The theoretical model of plasma and absorption wave produced by fused quartz irradiated by a millisecond-nanosecond pulsed laser is established, in which pulse delay and laser energy are essential variables. The results show that the damaged effect of the millisecond-nanosecond combined pulse laser is different under the damaged effect of different pulse delay conditions. When the energy densities of millisecond-nanosecond combined pulse lasers are 800 J/cm2 and 20 J/cm2, respectively, the range of pulse delay is 0 ms < Δt ≤ 3 ms, and the energy coupling efficiency is the highest when Δt = 1 ms. The addition of a nanosecond pulsed laser causes more obvious thermal damage and optical breakdown to fused quartz. The high pressure is concentrated at the plasma expansion interface or the shock wave front. The results can optimize the simulation parameters and be applied to laser plasma processing technology.
Dialogue d’Eros et de Pornos pris aux nœuds
Authors: Dadoun Roger 
Published: April 2023

Le rapport entre érotisme et pornographie -sans cesse remis en question -est figuré par deux personnages, Éros et Pornos. Personnages contrastés : Éros se présente comme étant du côté de la lumière, de la créativité, Pornos occupe un espace plus sombre, et tient des propos qui se veulent réducteurs et à ras de terre ; il revendique une sexualité quasiment adhérente aux organes et fonctions du corps -alors qu’Éros en fait une donnée essentiellement problématique et fondatrice de la condition humaine.
Cependant, l’opposition est difficile à maintenir ; des jeux de lumières et un fil qui relie les personnages l’un à l’autre sur la scène doivent suggérer des amalgames et permettre de les associer et en quelque façon de les confondre.
Des corps toujours vêtus d’images
Authors: Gattinoni Christian 
Published: April 2023

À l’exception des modifications apportées à l’intérieur du nu comme genre artistique avec des artistes tel Helmut Newton, des écrivains, de Pascal Quignard à Bernard Noël, et des artistes affirment que les corps apparemment nus restent toujours vêtus d’images. Dany Leriche, Annie Sprinkle ou Yasumasa Morimura en profitent pour interroger l’héritage historique et culturel de l’image de la femme.
Avec Nobuyoshi Araki, à travers le journal d’une vie, l’identité sexuelle réaffirmée met en lumière la peau comme écran -limite à transgresser. Hiromix assume quant à elle le devenir clone de l’être humain, qu’Inez Van Lamsweerde et Vanessa Beecroft explorent jusque dans ses extrêmes conséquences.
Joan Soulimant et Danièle Buetti montrent les hens intimes entre nudité, peau et corps interne.
Avec Éric Rondepierre et Matthew Barney la question dehors-dedans se trouve transférée aux passages d’images photocinémavidéo.
Faisant retour à la radicalité de Michel Joumiac nous comprenons que le marquage social de la peau qu’il dénonçait concerne aujourd’hui des oppositions importantes entre le psychisme dans sa relation à l’extériorité, comme la séparation des corps et des sociétés, entre réel et virtuel. Les artistes engagent ici une nouvelle expérience synesthésique de la chair virtuelle, d’autres liens, via les technologies, du corps à l’inconscient.
The Impact of Inflation and Unemployment on Income Inequality in Pakistan
Authors: Shabnum Sumera , Malik Zilakat 
Published: April 2023

Income Inequality is the main obstacle in eradicating poverty. This research calculates the estimated degree of income disparity in Pakistan through various techniques. It finds out the impact of macroeconomic factors like inflation, unemployment and GDP growth rate on the degree of income inequality using logit model on data from 1980 to 2020. Gini Index shows that income inequality is more for urban regions as compared to rural areas of Pakistan. Whereas among the provinces, Punjab is suffering the most from unfair distribution of income. The regression results show the significance of all selected variables toward income inequality in Pakistan. It shows that inflation and unemployment have negative impact on Gini index while GDP growth rate has a positive influence which is quite possible in a developing country like Pakistan lagging behind in industrialization and service provisions. The study helps in making certain policies to reduce income inequality.
Primary trauma care courses in Gaza
Authors: KBE Sir Terence English 
Published: April 2023

For the last 14 years the Primary Trauma Care Foundation, of which I am the Patron, has delivered courses in Primary Trauma Care to over 40 developing countries. Doctors in these countries, both in the cities and in rural areas, have then been better equipped to deal with patients with serious injuries. The courses, which are systematic and didactic, are of two days duration and are conducted by volunteers. These are followed by a one-day course for instructors, who then assume responsibility for teaching the course to doctors and nurses in their local area. The training manual has now been translated into 14 languages, including Arabic.

For the last 14 years the Primary Trauma Care Foundation, of which I am the Patron, has delivered courses in Primary Trauma Care to over 40 developing countries. Doctors in these countries, both in the cities and in rural areas, have then been better equipped to deal with patients with serious injuries. The courses, which are systematic and didactic, are of two days duration and are conducted by volunteers. These are followed by a one-day course for instructors, who then assume responsibility for teaching the course to doctors and nurses in their local area. The training manual has now been translated into 14 languages, including Arabic.