bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile
Authors: Zhang Jia-Yuan , Whalley Justin P. , Knight Julian C. , Wicker Linda S. , Todd John A. , Ferreira Ricardo C. 
Published: September 2023

Abstract
Background
The immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in COVID-19 patients has been extensively investigated. However, much less is known about the long-term effects of infection in patients and how it could affect the immune system and its capacity to respond to future perturbations.

Methods
Using a targeted single-cell multiomics approach, we have recently identified a prolonged anti-inflammatory gene expression signature in T and NK cells in type 1 diabetes patients treated with low-dose IL-2. Here, we investigated the dynamics of this signature in three independent cohorts of COVID-19 patients: (i) the Oxford COVID-19 Multi-omics Blood Atlas (COMBAT) dataset, a cross-sectional cohort including 77 COVID-19 patients and ten healthy donors; (ii) the INCOV dataset, consisting of 525 samples taken from 209 COVID-19 patients during and after infection; and (iii) a longitudinal dataset consisting of 269 whole-blood samples taken from 139 COVID-19 patients followed for a period of up to 7 months after the onset of symptoms using a bulk transcriptomic approach.

Results
We discovered that SARS-CoV-2 infection leads to a prolonged alteration of the gene expression profile of circulating T, B and NK cells and monocytes. Some of the genes affected were the same as those present in the IL-2-induced anti-inflammatory gene expression signature but were regulated in the opposite direction, implying a pro-inflammatory status. The altered transcriptional profile was detected in COVID-19 patients for at least 2 months after the onset of the disease symptoms but was not observed in response to influenza infection or sepsis. Gene network analysis suggested a central role for the transcriptional factor NF-κB in the regulation of the observed transcriptional alterations.

Conclusions
SARS-CoV-2 infection causes a prolonged increase in the pro-inflammatory transcriptional status that could predispose post-acute patients to the development of long-term health consequences, including autoimmune disease, reactivation of other viruses and disruption of the host immune system-microbiome ecosystem.
Dietary supplementation of laminarin improves the reproductive performance of sows and the growth of suckling piglets
Authors: Zhang Pengguang , Jiang Guoyuan , Ma Chenghong , Wang Yubo , Yan Enfa , He Linjuan , Guo Jianxin , Zhang Xin , Yin Jingdong 
Published: September 2023

Abstract
Background
Maternal nutrition is essential in keeping a highly efficient production system in the pig industry. Laminarin has been shown to improve antioxidant capacity, reduce the inflammatory response, and favor the homeostasis of intestinal microbiota. However, the effect of dietary supplementation of laminarin on the reproductive performance of sows and the growth of suckling offspring remains unknown.

Methods
A total of 40 Landrace × Yorkshire multiparous sows on d 85 of gestation, similar in age, body weight (BW), parity and reproductive performance, were randomly divided into four dietary treatments with 10 sows per treatment, receiving a control diet (basal pregnancy or lactating diets) and a basal diet supplemented with 0.025%, 0.05% and 0.10% laminarin, respectively. The experiment lasted from d 85 of gestation to d 21 of lactation.

Results
Laminarin supplementation linearly increased number born alive per litter (P = 0.03), average daily feed intake (ADFI, P < 0.01), and total milk yield of sows during the lactation of 1–21 d (P = 0.02). Furthermore, maternal laminarin supplementation increased the average daily gain (ADG) of piglets while tending to reduce the culling and death rate before weaning. In addition, alterations to the composition of colostrum and milk, as well as to serum inflammatory cytokines and immunoglobulins of sows were observed. The fecal microbiota profile of sows supported the improvement of reproductive performance in sows and the growth performance in suckling offspring.

Conclusions
Dietary supplementation of laminarin during late pregnancy and lactation could significantly improve reproductive performance of sows and growth performance of piglets.

Graphical Abstract
Between settlement, double return and re-emigration: motivations for future mobility of Polish and Lithuanian return migrants
Authors: Czeranowska Olga , Parutis Violetta , Trąbka Agnieszka 
Published: September 2023

AbstractAlthough research on return migration is growing, little is known about returnees’ plans and attitudes regarding further migration. This article contributes to the filling of this knowledge gap by studying the likelihood of engaging in further mobility among Polish and Lithuanian returnees. Using a mixed method approach we explore under which circumstances return migrants intent to stay in their country of origin permanently and what factors would make them consider leaving again. Our quantitative sample (CAWI survey) consists of 740 responses from Poles and Lithuanians who returned to their home countries from the UK. We conducted a binary logistic regression analysis concerning plans to move abroad again. In the qualitative part of the analysis, based on in-depth interviews with 60 Polish or Lithuanian returnees, we have contextualised quantitative results by presenting four case studies representing different likelihoods of re-migrating. Our research shows that both return and post-return plans are always negotiated in the context of a variety of personal, family and professional considerations. Having a job, having children and strong attachment to the current place of living turned out to be the strongest negative predictors of the likelihood of further migration.
A deep-learning system to help make the surgical planning of coil embolization for unruptured intracranial aneurysms
Authors: Nie Xin , Yang Yi , Liu Qingyuan , Wu Jun , Chen Jingang , Ma Xuesheng , Liu Weiqi , Wang Shuo , Chen Lei , He Hongwei 
Published: September 2023

Abstract
Background
Coil embolization is a common method for treating unruptured intracranial aneurysms (UIAs). To effectively perform coil embolization for UIAs, clinicians must undergo extensive training with the assistance of senior physicians over an extended period. This study aimed to establish a deep-learning system for measuring the morphological features of UIAs and help the surgical planning of coil embolization for UIAs.

Methods
Preoperative computational tomography angiography (CTA) data and surgical data from UIA patients receiving coil embolization in our medical institution were retrospectively reviewed. A convolutional neural network (CNN) model was trained on the preoperative CTA data, and the morphological features of UIAs were measured automatically using this CNN model. The intraclass correlation coefficient (ICC) was utilized to examine the similarity between the morphologies measured by the CNN model and those determined by experienced clinicians. A deep neural network model to determine the diameter of first coil was further established based on the CNN model within the derivation set (75% of all patients) using neural factorization machines (NFM) model and was validated using a validation set (25% of all patients). The general match ratio (the difference was within ± 1 mm) between the predicted diameter of first coil by model and that used in practical scenario was calculated.

Results
One-hundred fifty-three UIA patients were enrolled in this study. The CNN model could diagnose UIAs with an accuracy of 0.97. The performance of this CNN model in measuring the morphological features of UIAs (i.e., size, height, neck diameter, dome diameter, and volume) was comparable to the accuracy of senior clinicians (all ICC > 0.85). The diameter of first coil predicted by the model established based on CNN model and the diameter of first coil used actually exhibited a high general match ratio (0.90) within the derivation set. Moreover, the model performed well in recommending the diameter of first coil within the validation set (general match ratio as 0.91).

Conclusion
This study presents a deep-learning system which can help to improve surgical planning of coil embolization for UIAs.
Use of Objective Structured Clinical Examination (OSCE) in a hybrid digital / in-person training for hormonal IUD in Nigeria: findings and applications of the approach
Authors: Nwokoma Ezechukwu , Anyasi Helen , Archie Samantha , Onyezobi Chinedu , OlaOlorun Funmilola , Anyanti Jennifer , Nwala Anthony , Afolabi Kayode , Little Kristen , Demise Eden , Danna Kendal , Rademacher Kate , Plotkin Marya 
Published: September 2023

Background: The hormonal intrauterine device, a long-acting reversible contraceptive method, is being introduced to pilot sites in the private and public sector in Nigeria by the Nigerian Federal Ministry of Health since 2019. To inform training of health care providers, a study was conducted on a hybrid digital and in-person training which utilized Objective Structured Clinical Examination (OSCE) to assess competency of provider trainees. This study represents one of few documented experiences using OSCE to assess the effectiveness of a digital training. Methods: From September – October 2021, in Enugu, Kano and Oyo states of Nigeria, 62 health care providers from public and private sector health facilities were trained in hormonal IUD service provision using a hybrid digital / in-person training approach. Providers, who were skilled in provision of copper IUD, underwent a didactic component using digital modules, followed by an in-person practicum, and finally supervised service provision in the provider trainee’s workplace. Skills were assessed using OSCE during the one-day practicum. Results: Use of the OSCE to assess skills provided valuable information to study team. The performance of provider trainees was high (average 94% correct completion of steps in the OSCE). Conclusions: OSCE was used as a research methodology as part of this pilot study; to date, OSCE has not been integrated into the training approach to be scaled up by FMOH. Uniformly high performance of provider trainees was seen on the OSCE, unsurprising since provider trainees were experienced in providing copper IUD. If and when training is rolled out to providers inexperienced with copper IUD, OSCE may have a more important role to assess skills before service provision. The role of OSCE in design of hybrid digital / in-person training approaches should be further explored in rollout of hormonal IUD and other contraceptive technologies.
AS FAMÍILIAS LABRIDAE, PERCOPHIDAE, LABRISOMIDAE, BLENNIIDÃAE, ELEOTRIDIDAE, TRICHIURIDAE, SCOMBRIDAE E STROMATEIDAE (PISCES, PERCIFORMES) NA COLEÇÃO DO LABORATÓRIO DE ICTIOLOGIA DA UNIVERSIDADE FEDERAL DO RIO DE JANEIRO.
Authors: Duarte Lopes Paulo Roberto 
Published: September 2023

É apresentado o material pertencente às familias Labridae, Percophidae, Labrisomidae, Blenniidae, Eleotrididae, Trichinridae, Scombridae e Stromateidae (totalizando 12 espécies e 92 exemplares) que se encontra depositado no Laboratório de Ictiologia (Departamento de Zoologia) da Universidade Tederal do Rio de Janeiro, A maioria dos exemplares aqui apresentados provém do litoral do Estado do Rio de Janeiro (Região Sudeste do Brasil), em especial da Baia de Guanabara. Alguns indivíduos foram coletados nos litorais dos estados da Bahia (Região Nordeste do Brasil), Espírito Santo (Região Sudeste do Brasil), e Santa Catarina (Região Sul do Brasil). Para cada espécie considerada são citados o nome vulgar (no Litoral Sudeste do Brasil), a distribuição geográfica (no Oceano Atlântico ocidental) e os dados relativos aos indivíduos estudados (procedência, total de exemplares depositados e respectivo número de registro na coleção). Nenhuma ampliação dos limites de distribuição geográfica foi assinalada para as espécies aqui consideradas.
CRIAÇÃO LITERÁRIA
Authors: Vilma Ângela , Cerqueira Anne , Marcelo Antonio , Maxado Franklin , Santos Alves Jecilma , Cosme Silva Santos Luis Rogerio , Oliveira José Plínio , Galvão Coutinho Marcus , Lopes Raymundo Luiz , Pereyr Roberval , Cosme Silva Santos Valéria 
Published: September 2023

Rebento, substantivo abstrato,
O ato, a criação, o seu momento,Como uma estrela nova e seu baratoQue só Deus sabe lá, no firmamento.
Gilberto Gil
Design and simulation of a near-infrared enhanced Si-based SPAD for an automotive LiDAR
Authors: Xie Sheng , Kong Xiangfa , Cong Jia , Mao Xurui , Fu Yan 
Published: September 2023

A near-infrared (NIR)-enhanced single-photon avalanche diode (SPAD) with a retrograded NM/XP junction for an automotive LiDAR was designed based on CSMC 0.18 µm BCD technology. A 3 µm depth NM/XP junction embedded in a lightly doped deep p-well (DP) improves the absorption efficiency in the NIR regime; the photo-generated electrons generated in the depletion region are efficiently collected into the central multiplication region by a drift process, and then the impact ionization is triggered by the strong field, resulting in a high photon detection efficiency (PDE). Additionally, the deep NM/XP junction and the buried layer effectively isolate the dark noise originating from the interface and the substrate. The SPAD was initially simulated by numerical calculation, and then was evaluated with active quench/reset electronics in a circuit simulator. The results revealed that the SPAD with an active area of 314µm2 achieves a PDE of 16.2% at 905 nm and a dark count rate (DCR) of 1.46Hz/µm2, with an excess bias of 5 V at room temperature. The designed SPAD is well suited for the low-cost, miniaturized automotive LiDAR.
Under-reporting of adverse drug reactions: Surveillance system evaluation in Ho Municipality of the Volta Region, Ghana
Authors: Buabeng Richard Osei , Dsane-Aidoo Paul , Asamoah Yaw K. , Bandoh Delia Akosua , Boahen Yvonne Adu , Sabblah George Tsey , Darko Delese Mimi , Lwanga Charles Noora , Ameme Donne Kofi , Kenu Ernest 
Published: September 2023

Background
Adverse Drug Reactions (ADRs) can occur with all medicines even after successful extensive clinical trials. ADRs result in more than 10% of hospital admissions worldwide. In Ghana, there has been an increase of 13 to 126 ADR reports per million population from 2012 to 2018. ADR Surveillance System (ADRSS) also known as pharmacovigilance has been put in place by the Ghana Food and Drugs Authority (FDA) to collect and manage suspected ADR reports and communicate safety issues to healthcare professionals and the general public. The ADRSS in Ho Municipality was evaluated to assess the extent of reporting of ADRs and the system’s attributes; determine its usefulness, and assess if the ADRSS is achieving its objectives.

Methods
We evaluated the ADRSS of the Ho Municipality from January 2015 to December 2019. Quantitative data were collected through interviews and review of records. We adapted the updated CDC guidelines to develop interview guides and a checklist for data collection. Attributes reviewed included simplicity, data quality, acceptability, representativeness, timeliness, sensitivity, predictive value positive and stability.

Results
We found a total of 1,237 suspected ADR during the period, of which only 36 (3%) were reported by healthcare professionals in the Ho Municipality to the National Pharmacovigilance Centre (NPC). Only 43.9% of health staff interviewed were familiar with the ADRSS and its reporting channel. Staff who could mention at least one objective of the ADRSS were 34.2%, and 12.2% knew the timelines for reporting ADR. Reports took a median time of 41 (IQR = 25, 81) days from reporter to NPC. Reports sent on time constituted 37.5%. Fully completed case forms constituted 77.1% and the predictive value positive (PVP) was 20%. About 53% of ADRs were reported for female patients. Up to 88.9% of ADRs were classified as drug related. Anti-tuberculosis agents and other antibiotics constituted (40.6%) and (18.8%) of all reports. The ADRSS was not integrated into the disease surveillance and response system of Ghana’s Health Service and so was not flexible to changes. A dedicated ADR surveillance officer in regions helped with the system’s stability. Data from Ghana feeds into a WHO database for global decision making.

Conclusions
There was under-reporting of ADRs in the Ho Municipality from January 2015 to December 2019. The ADR surveillance system was simple, stable, acceptable, representative, had a strong PVP but was not flexible or timely. The ADRSS was found useful and partially met its objectives.
The Multi-Balloon Theory
Authors: Khetarpal Akshaj 
Published: September 2023

The Multi-Balloon Theory, is based on the observation that the universe is expanding, and that the rate of expansion is accelerating. This expansion continues to this day. The behaviour of matter within the expanding universes is a complex topic to understand. Yet, its significance is undeniable, as it will explain many phenomenon such as increasing distance between galaxies, the formation of black holes and the properties and the formation of dark matter.
The theory encompasses alternative concepts concerning the formation of the Universe, including the 'Big Bang Theory' and the multiverse hypothesis. Additionally, it draws support from empirically validated principles and equations like Einstein's field equations and Oort constants, employing them to substantiate its own framework.
The Multi-Balloon Theory ultimately explains the structure of the universe and the nature as well as behaviour of matter within the expanding universes.
Creep behavior of layered salt rock under triaxial loading and unloading cycles
Authors: Zhao Yanlin , Wang Xiaguang , Tang Wenyu , Li Yang , Lin Hang , Wang Yixian , Zhang Lianyang 
Published: September 2023

Abstract
This paper presents an extensive laboratory investigation of layered salt rocks under triaxial loading and unloading cycles aiming to better understand their viscoelastic plasticity strain characteristics. Specifically, creep curves were obtained from the triaxial loading and unloading tests and analyzed using the Burgers model. The microstructure of the layered salt rocks before and after the creep test was comparatively analyzed using the dry grinding optical diagram. The results show that the creep deformation of layered salt rocks is mainly viscoelastic under a low deviatoric stress and contains both viscoelastic and viscoplastic deformations when the deviatoric stress is high. With the increase of deviatoric stress, both the instantaneous elastic and plastic strains increase, and the increasing rate becomes lower as the deviatoric stress increases. The creep curves of layered salt rocks can be well represented with the Burgers model. Since the creep leads to fracturing and interlayer rupturing and producing new fluid seepage channels in layered salt rocks, this study has great value for understanding the long-term performance of gas and hydrocarbon liquid storage caverns in layered salt rock formation.
Why does Gen Z watch virtual streaming VTube anime videos with avatars on Twitch?
Authors: Li Yijin 
Published: September 2023

Abstract

Purpose
Live streaming has become an increasingly popular media, which allows individuals to record and broadcast simultaneously on the internet. Streamers, individuals who conduct live streaming videos, create diverse media content on live streaming video platforms. Most streamers show up with their real-person appearances via live streaming. However, Virtual YouTubers, known as VTubers, use avatars to conduct live streaming. In recent years, Twitch has become one of the most well-known video live streaming services for VTubers. This study aims to explore attractiveness between the viewer and VTuber through parasocial interactions, and the influence that attractiveness might have on actual mediated interactions between viewers and the VTuber.

Design/methodology/approach
A questionnaire was conducted to study the attractiveness of VTubers’ live streaming and viewers’ engagement with VTubers.

Findings
Parasocial interactions can be a factor drawing viewers to watch VTubers’ live streaming. Physical attractiveness, social attractiveness, and task attractiveness play important roles in influencing viewers’ choices on specific VTuber’s live streaming and further social interactions with them. To be more specific, the interactions with VTubers, the content of live streaming, the personality of VTubers, and the visual design of the VTubers’ avatars are important factors that attract respondents to watch live streaming. Additionally, the findings show the pattern of viewers’ interactions with VTubers. Active viewers typically leave comments to be acknowledged by VTubers and further reactions. Passive viewers are influenced by time, language barrier, character, and emotional health.

Practical implications
VTubers and the platform are given suggestions on how to design and improve live streams and help VTubers to promote to attract viewers.

Social implications
It introduces VTubing as a subculture and shows how viewers consume VTubers’ live streaming.

Originality/value
This is the first study to explore the roles of attractiveness on viewers selecting and engaging with VTubers’ live streaming. It illustrates the importance of companionship, avatars, and the personality of VTubers in influencing viewers’ willingness to watch live streaming.
Stimulus-Specific Prediction Error Neurons in Mouse Auditory Cortex
Authors: Audette Nicholas J. , Schneider David M. 
Published: September 2023

Comparing expectation with experience is an important neural computation performed throughout the brain and is a hallmark of predictive processing. Experiments that alter the sensory outcome of an animal's behavior reveal enhanced neural responses to unexpected self-generated stimuli, indicating that populations of neurons in sensory cortex may reflect prediction errors (PEs), mismatches between expectation and experience. However, enhanced neural responses to self-generated stimuli could also arise through nonpredictive mechanisms, such as the movement-based facilitation of a neuron's inherent sound responses. If sensory prediction error neurons exist in sensory cortex, it is unknown whether they manifest as general error responses, or respond with specificity to errors in distinct stimulus dimensions. To answer these questions, we trained mice of either sex to expect the outcome of a simple sound-generating behavior and recorded auditory cortex activity as mice heard either the expected sound or sounds that deviated from expectation in one of multiple distinct dimensions. Our data reveal that the auditory cortex learns to suppress responses to self-generated sounds along multiple acoustic dimensions simultaneously. We identify a distinct population of auditory cortex neurons that are not responsive to passive sounds or to the expected sound but that encode prediction errors. These prediction error neurons are abundant only in animals with a learned motor-sensory expectation, and encode one or two specific violations rather than a generic error signal. Together, these findings reveal that cortical predictions about self-generated sounds have specificity in multiple simultaneous dimensions and that cortical prediction error neurons encode specific violations from expectation.SIGNIFICANCE STATEMENTAudette et. al record neural activity in the auditory cortex while mice perform a sound-generating forelimb movement and measure neural responses to sounds that violate an animal's expectation in different ways. They find that predictions about self-generated sounds are highly specific across multiple stimulus dimensions and that a population of typically nonsound-responsive neurons respond to sounds that violate an animal's expectation in a specific way. These results identify specific prediction error (PE) signals in the mouse auditory cortex and suggest that errors may be calculated early in sensory processing.