bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Study of Interaction of Melphalan with SWCNT- BNNT Through Force Fields Molecular Mechanics and Quantum Calculations in Different Solvents and Temperatures
Authors: Hasanzadeh Neda , Jamshidi Mohammad Hassan , Yahyaei Hooriye , Bahrami Amir 
Published: January 2023

Abstract:In this study, the interaction of Melphalan, which is an anti-cancer medicine, with Singlewall carbon nanotubes (SWCNTs) and Boron nitride nanotubes (BNNTs), was investigated. Calculations were performed by using two methods of quantum mechanics and molecular mechanics. Thermodynamic parameters and Frontier Molecular Orbitals (FMOs) of the title compounds were evaluated by using the Density Functional Theory (DFT) calculations. The Quantum Mechanics calculations proved that BNNTs are more suitable carriers for Melphalan. Moreover, the interaction of Melphalan with SWCNTs and BNNTs at different temperatures was evaluated by Monte Carlo calculations. The MM+ force field was chosen as the most efficient field, and the HCl solvent has the lowest amount of energy and proven to be the most stable solvent for the simulation. The most significant finding obtained from this study is that the results of all types of calculations are in line with each other regarding both thermodynamic properties and conformers.
GOQDs and GOQDs-NS-doped Carbocatalysts: A Concise Study on
Production and Use in One-pot Green MCRs
Authors: Rostamizadeh Shahnaz , Zamiri Bahram , Mahkam Mehrdad , Azar Aghbelagh Parvin Beigi 
Published: January 2023

Introduction:
Nowadays, the catalysts’ usage in chemical reactions is unavoidable, and this
has led scientists to look for producing and using catalysts which not only cause pollution and toxicity
in the reactions and products, but also generate economical benefits.

Aims:
Our goal in this paper is to produce a fully biocompatible, non-toxic and inexpensive carbocatalyst
with a graphene oxide structure for use in multi-component reactions as a heterogeneous catalyst.

Methods:
The research has been carried out to simplify the method of preparing carbocatalysts. In this
article, we heated citric acid and thiourea in the simple bottom-up method in which nitrogen and sulfur
were atomically inserted into a carbon-carbon bond of graphene oxide.

Results:
The results have been obtained by comparing graphene oxide quantum dots (GOQDs) and
functional graphene oxide quantum dots (GOQDs) and functional nitrogen and sulfur-doped graphene
oxide quantum dots (NS-doped-GOQDS) using the produced carbocatalyst in the synthesis of spiro
indoline pyrano pyrazoles and highly substituted pyridine derivatives with chemical and pharmacological
properties.

Conclusion:
A simple and affordable bottom-up method has been developed to synthesize fluorescent
NS-doped-GOQDS by the condensation of CA in the presence of thiourea with water elimination at
185 ℃. After the production of NS-doped-GOQDS, the carbocatalyst is used in the synthesis of
spiro[indoline-3,4'-pyrano [2, 3-c]pyrazole] derivatives in four-component reactions and pyridine derivatives
in five-component reactions.
Huatan Tongluo Decoction Inhibits Inflammatory Infiltration and Airway
Remodeling by Attenuating TGF-β1/Smad2/3 and Oxidative
Stress-mediated NF-kB/HIF-1α/MMPs Signaling Pathway in Chronic
Asthma Mice
Authors: Lao Huimin , Chen Mengqi , Liu Xuanyu , Li Libo , Li Qian , Zhang Baoqing 
Published: January 2023

Background:
Asthma is a common chronic respiratory disorder characterized by inflammation
and remodeling of the airways.

Aims:
This study aimed to identify the inhibitory effects of Huatan Tongluo decoction (HTTLD) on airway
inflammation and associated remodeling mechanisms.

Methods:
Mice were immunized with ovalbumin (OVA) for 8 weeks to generate chronic asthma mouse
models (CAS), which were randomly divided into 4 groups administrated with pachyman, dexamethasone
(DEX), HTTLD, and without anything (CAS model), while mice who administrated saline were assigned
as the control group. Hematoxylin-eosin (H&E) and Masson trichrome were used to determine inflammatory
infiltration and airway remodeling (fiber deposition). Inflammatory cytokines, including VEGF,
PDGF, and TGF-β1, were analyzed using ELISA. The gene transcriptions and expressions of MMP-9,
TIMP-1, VEGF, HIF-1α, NF-kB, and β-actin were evaluated using RT-PCR and Western blot, while the
expression of p-Smad2/3 was determined by Western blot.

Results:
HTTLD inhibited inflammatory infiltration and airway remodeling (reducing airway wall thickness
and decreasing fiber deposition) of lung tissues in the CAS mouse model. HTTLD markedly attenuated
levels of TGF-β1, VEGF, and PDGF compared to those of mice in the CAS model group (p < 0.05).
HTTLD significantly reduced the secretion of matrix metalloproteinases (MMP-9 and TIMP-1) and the
expression of NF-kB/HIF-1α compared to mice in the CAS model group (p < 0.05). HTTLD prominently
downregulated phosphorylated levels of the Smad2/3 molecule (ratio of p-Smad3/2/Smad2/3) compared
to mice in the CAS group (p < 0.05).

Conclusion:
HTTLD inhibited inflammatory infiltration and airway remodeling in an OVA-induced
chronic asthma mouse model by attenuating the TGF-β1/Smad2/3 signaling pathway and suppressing the
oxidative stress-mediated NF-kB/HIF-1α/MMPs signaling pathway.
Value of CT and MR Imaging in Assessment of Loco-regional Ablated
Hepatocellular Carcinoma using LI-RADS Treatment Response Algorithm
(version 2018)
Authors: Abd-Elsalam Sherief , Zarad Carmen Ali , Elagawy Waleed , Hasan Basma Badreldin , Abo Shanab Waleed S. 
Published: January 2023

Aim:
The aim of this work is to evaluate the role of multiphasic CT and dynamic contrast
enhanced MRI using LI-RADS treatment response algorithm (version 2018) and the added values of
diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps in the assessment
of loco-Regional ablated Hepatocellular Carcinoma (HCC).

Methods:
This study included 45 patients with 50 loco-Regional ablated HCC lesions. All patients
underwent multiphasic CT scan, diffusion weighted and dynamic contrast enhanced MRI. The reference
standards for assessment were based on serum alpha-fetoprotein level and dynamic contrast
enhanced MRI.

Results:
Multi-phasic CT had moderate sensitivity (87.5%) and high specificity (100%) for assessment
of HCC LI-RADS treatment response algorithm. Dynamic contrast enhanced MRI had high
sensitivity (100%) and specificity (100%) for the assessment of HCC LI-RADS treatment response
algorithm. The sensitivity and specificity of DWI to diagnose HCC malignant residual or recurrence
were 93.7% and 100%, respectively, with very good performance. The mean ADC values of the
malignant residual or recurrence were significantly lower than that of benign post-ablation tissue
changes areas and the best ADC cutoff value for differentiation between viable and nonviable lesions
was 1.1x10-3 mm²/s.

Conclusion:
Performance of dynamic contrast enhanced MRI is better than that of multiphasic CT in
the assessment of LIRADS treatment response algorithm. DWI and ADC maps could be used as
ancillary methods for differentiation between viable and non-viable loco-regional ablated HCC lesions
and should be included in LR-TR treatment response algorithm.
Middle Ear Teratoma: Clinical and Imaging Features
Authors: Liu Jun-hua , Huang Wen-hu , Liu Yin , Zhang Fang , Sha Yan 
Published: January 2023

Background:
Teratoma is a true neoplasm composed of a number of different types of tissue
derived from the three germinal layers but rarely occurs in the middle ear (ME). The features of
middle ear teratomas (MET) have not been well described.

Objective:
The objective of this study is to explore the clinical and imaging features of MET, and report
2 rare cases of MET with ear malformation that have never been reported.

Materials and Methods:
The clinical, CT and MRI data of 8 patients with a pathological diagnosis of
MET were collected and retrospectively mined, and 14 patients with MET reported in previous literature
were also reviewed.

Results:
① Female, left ear predominance in MET, and the most common symptoms were otorrhea
and hearing loss. ② On CT and MRI, the MET presented as an irregular soft tissue mass that was
heterogeneous, with fatty tissue and involved multiple sites, and the ET and tympanum were correspondingly
expanded and locally destroyed. ③ Mictotia with MET in two patients was presented,
which was the first report.

Conclusion:
MET has female sex and left ear predominance. CT and MRI can be used to diagnose
MET and display its extent and its relationship to the carotid canal in detail. Complete surgical excision
is the definitive treatment.
Prophylactic Agents for Preventing Cardiotoxicity Induced Following
Anticancer Agents: A Systematic Review and Meta-Analysis of Clinical
Trials
Authors: Amin Hashemipour Seyed Mohammad , Valizadeh Rohollah , Keshavarzian Ehsan , Sadighpour Tella , Mortazavizadeh Seyed Mohammadreza , Soltani Mohammadhossein , Motevalipoor Amir Farzin , Khamas Shahriyar Shahbazi , Moazen Mohammad , Kogani Mohammad , Hosseinpour Hamid 
Published: January 2023

Background:
Anthracyclines can improve survival in many types of malignancies, but
dose-dependent and irreversible results following the use of anthracyclines have been associated
with cardiomyopathy. This meta-analysis aimed to compare the effects of prophylactic agents for
preventing cardiotoxicity induced following anticancer agents.

Methods:
In this meta-analysis, Scopus, Web of Science, and PubMed were surfed for articles
published by December 30th, 2020. The keywords were angiotensin‐converting enzyme inhibitor
(ACEI), enalapril, captopril, angiotensin receptor blocker, beta blocker, metoprolol, bisoprolol,
isoprolol, statin, valsartan, losartan, eplerenone, idarubicin, nebivolol, dihydromyricetin, ampelopsin,
spironolactone, dexrazoxane, antioxidants, cardiotoxicity, n-acetyl-tryptamine, cancer, neoplasms,
chemotherapy, anthracyclines, doxorubicin, daunorubicin, epirubicin, idarubicin, ejection fraction or a
combination of them in the titles or abstracts.

Results:
A total of 17 articles out of 728 studies examining 2,674 patients were included in this
systematic review and meta-analysis. Ejection fraction (EF) values in the baseline, 6-month, and
12-month follow-up in the intervention group turned out to be 62.52 ± 2.48, 59.63 ± 4.85, and
59.42 ± 4.53, whereas in the control group appeared to be 62.81 ± 2.58, 57.69 ± 4.32, and 58.60 ±
4.58, respectively. Through comparison of the two groups, EF was found to increase in the
intervention group by 0.40 after 6 months (Standardized mean difference (SMD): 0.40, 95%
confidence interval (CI): 0.27, 0.54), thus proving higher than that of the control groups
following the cardiac drugs.

Conclusion:
This meta-analysis showed that prophylactic treatment with cardio-protective drugs,
including dexrazoxane, beta blocker, and ACEI drugs in patients undergoing chemotherapy with
anthracycline, have a protective effect on LVEF and prevent EF drop.
Natural Products and Derivatives Applied for Skin Care: An Updated
Review
Authors: Kumar Virender , Kumar Nakul , Singh Gajendra 
Published: January 2023

Abstract:
In contemporary cosmetics, botanicals and natural extracts remain vital components and
have been used in formulations since ancient times. However, natural and botanical products can
still be highly effective in treating aging skin, even though they are becoming more technological
and invasive. Many natural products are being elucidated through biochemical mechanisms of action,
correlating with traditional uses of many plants for skin benefits. Different formulations of
medicinal and pharmaceutical substances incorporate synthetic molecules and chemicals, which is
the principal cause of dermal toxicity. Consumers' awareness about personal health and safety and
the desire for safer cosmetics free of harmful chemicals have driven the cosmetics and personal care
market toward natural ingredients. The commercialization of natural products derived from herbs
and bees is possible. Our purpose is to present a comprehensive and critical review emphasizing the
benefits of natural products for skin care, women's purchasing patterns, and updated information
about natural products.
Lxs niñxs y las mujeres de Casa de Gobierno en AtyKwakúmuke (Pueblo bello, Colombia): pautas de crianza y acceso a la justicia sexual en la Sierra Nevada
Authors: Restrepo Galvis Laura Sofía , Santamaria Ángela , Izquierdo Digneris , Moreno Reza Gabriel Elias 
Published: January 2023

Este artículo presenta las experiencias de crianza y formación para el liderazgo de un grupo de niñas y mujeres arhuacas en el municipio de AtyKwakúmuke en Pueblo Bello, Cesar (Colombia), desde una perspectiva femenina arhuaca de la administración de la justicia propia en casos de violencia sexual. En este sentido, nos preguntamos: ¿quiénes son lxs niñxs y las mujeres que hacen parte de este proceso de atención y prevención de la violencia sexual en el pueblo arhuaco? ¿Cómo participan las lideresas y sus hijxs en la escuela de niñxs de Casa de Gobierno?
Desde el punto teórico cruzamos dos tipos distintos de literatura. Por un lado, elementos teóricos sobre la crianza (García Peralta y García Peralta, 2019; Braun y Clarke, 2006); por el otro, los estudios de los procesos de justicia de mujeres indígenas (Sieder, 2016). Desde el punto de vista metodológico proponemos procesos de investigación/acción participativa feminista (Lykes y Crosby, 2013) a través de bitácoras, cartografías, corpografías y elaboración de muñecas como artefactos memoriales que valorizan los conocimientos tradicionales femeninos arhuacos, reflexionando sobre la justicia y la gobernanza de niñxs y mujeres.
O uso de fitoterápicos no tratamento do Diabetes Mellitus: uma revisão da literatura
Authors: Cuzzuol Vitor Realli Gaspar , Leal Carina Maria Dalmonech Loterio , Rosetti Késia Alves Gomes , Damasceno Natalia Salvador de Souza 
Published: January 2023

No Brasil, aproximadamente 9,1 milhões de pessoas são portadoras de diabetes mellitus, uma doença proveniente de falhas nos mecanismos metabólicos e que tem por consequência a hiperglicemia e várias outras complicações. Entre os programas ofertados pelo Sistema Único de Saúde para o seu controle, destaca-se a fitoterapia, que vem se mostrando bastante eficaz, conforme evidenciam os resultados de diferentes estudos. Por meio deste artigo de revisão, propõe-se conhecer e analisar a produção científica publicada acerca do uso de fitoterápicos e plantas medicinais no tratamento do diabetes mellitus. Para tal, optou-se pela realização de um estudo bibliográfico, em que foram analisadas publicações a partir de 1990. As plantas que obtiveram resultados positivos em diversos estudos foram as espécies: Bauhinia forficata (pata-de-vaca), Syzygium cumini (jamelão), Sphagneticola trilobata (insulina), Cissus sicyoides L (insulina vegetal), carqueja, tintura de mororó, Stevia rebaudiana, Chrysobalanus icaco Lin (abajeru), Myrcia multiflora (pedra-ume-caá) e epicarpo da romã. As evidências acerca dos benefícios proporcionados pelo uso das plantas medicinais corroboram a necessidade de investimento para sua utilização adequada e melhoria da qualidade de vida do paciente diabético.
Anmeldelser
Authors: Elling Bo , Blok Anders 
Published: January 2023

Anmeldelser af følgende:

Klaus Rasborg: ULRICH BECK – en kritisk indføring i teorien om verdensrisikosamfundet. Anmeldt af Bo Elling.
Sanjay Seth: Beyond reason: postcolonial theory and the social sciences. Anmeldt af Anders Blok.
Electrical and mechanical properties of catalytically-grown multi-walled carbon nanotube-reinforced epoxy composite materials
Authors: Chen Junjie 
Published: January 2023

Carbon nanotubes are excellent candidates for the development of
nano-reinforced polymer composite materials. However, assurance of
homogeneous dispersion, interfacial compatibility between the carbon
nanotube and the polymer, and exfoliation of the aggregates of carbon
nanotubes, are required for the successful integration of carbon
nanotubes into nanocomposites. The present study is focused primarily
upon the electrical and mechanical properties of catalytically-grown
multi-walled carbon nanotube-reinforced epoxy composite materials.
Particular emphasis is placed upon the effect of carbon loading on the
electrical conductivity and the influence of temperature on the loss
factor and modulus for the composite materials. The results indicate
that the electrical properties of the composite would not be changed
from those of the bulk polymer until the average distance between the
carbon nanotubes is reduced such that either electron tunneling through
the polymer or physical contacts may be formed. Among the challenges
introduced in the fabrication of carbon nanotube-filled polymer
composites is the necessity to creatively control and make use of
surface interactions between carbon nanotubes and polymeric chains in
order to obtain an adequate dispersion throughout the matrix without
destroying the integrity of the carbon nanotubes. Frequency domain
material properties are therefore limited to applications where strains
are small and stress is approximately linear with strain and the strain
rate. Frequency domain material properties become irrelevant if the
material exhibits nonlinear elastic behavior or is subjected to large
strains. Depending on the type of polymers in the matrix, above a
certain temperature limit, degradation starts or cross-linking starts.
The deformed elastic body possess an amount of potential energy equal to
the initial amount of potential energy minus the amount of energy
irreversibly dissipated. The modulus and loss factor variables of a
damping material are highly dependent upon the temperature of the
damping material and the vibration frequency. Because of their
viscoelastic nature, the stress and strain in viscoelastic materials are
not in phase, and, in fact, exhibit hysteresis. The resonant frequency
is related to the modulus of the catalytically-grown multi-walled carbon
nanotube-reinforced epoxy composite.
Keywords: Composite materials; Electrical properties;
Mechanical properties; Carbon nanotubes; Electrical conductivity; Loss
modulus
Eksekusi Jaminan Fidusia dengan Title Eksekutorial; “Analisa Penerapan Hukum Proses Eksekusi Obyek Jaminan” (Studi kasus di Kota Cirebon)
Authors: Sampurna Putri Sari ageng jaya 
Published: January 2023

Semangkin meningkatnya kebutuhan masyarakat akan kendaraan bermotor di Indonesia saat ini membawa peningkatan pula kepada penggunaan jasa pembiayaan konsumen. Peningkatan penggunaan jasa pembiayaan konsumen oleh masyarakat perlu pula ditingkatkan dengan peraturan hukum terkait yang baik.. Salah satu aturan hukum terkait pembiyaan konsumen yang perlu diatur adalah mengenai eksekusi obyek jaminan. Peraturan hukum pembiayaan konsumen yang baik salah satunya dapat dilihat ketika eksekusinya obyek jaminan telah mematuhi aturan hukum terkait. Perumusan masalah yang menjadi dasar penelitian ini adalah (1) Bagaimana penerapan hukum eksekusi jaminan fidusia dengan title eksekutorial. (2) Apakah Hambatan dalam penerapan hukum eksekusi obyek jaminan fidusia dengan title eksekutorial. Penelitian ini menggunakan metode pendekatan yuridis empiris dimana peneliti akan menguraikan fakta-fakta yang ada dilapangan disandingkan dengan peraturan Undang-Undang yang berlaku. Penelitian ini dilakukan guna megetahui Bagaimana penerapan hukum eksekusi jaminan fidusia dengan title eksekutorial dan Apakah Hambatan dalam penerapan hukum eksekusi obyek jaminan fidusia dengan title eksekutorial. Hasil penelitian eksekusi benda jaminan belum menerapkan aturan hukum terkait eksekusi obyek jaminan fidusia dengan Menggunakan tittle eksekutorial. Beberapa perusahaan pembiayaan dan konsumen perusahaan pembiyaan mengakui masih adanya penarikan tanpa adanya persetujuan debitor, dimana hal ini menyalahi aturan tentang eksekusi obyek jaminan fidusia dengan Menggunakan tittle eksekutorial terutama yang termuat dalam Mahkamah Konstitusi nomor 18/PUU-XVII/2019 yang telah merubah pasal 15 Undang-Undang Jaminan Fidusia mengenai “tittle eksekutorial” sehingga tidak dibenarkan lagi melakukan eksekusi benda jaminan tanpa adanya persetujuan debitor atau putusan pengadilan yang berkekuatan hukum tetap.
TIGA FASE NISBAH HUKUM GEREJA DENGAN HUKUM SIPIL
Authors: Binawan Andang 
Published: January 2023

This paper discusses the changing relationship between canonic law and state (civil) law in history. In general, we can discern three stages: domination, confrontation-conflic and lastly harmony. The stages are marked by theories or principles describing or justifying the current situation. Pope Gelasius, for instance, forward the double sword principle. With the advent of nation-states and emerging scientific approach to reality, we enter the confrontation stage between Church Law and positive secular laws made by nations states. The third stage is marked by the 2nd Vatican Council, putting forward two important principles, i.e., salus animarum suprema lex and salus populi suprema lex, determining the relationship between Church law and secular laws.
استخدام التحليل الرقمي للبيانات الفضائية في دراسة الغطاء النباتي وحالة سطح التربة في قضاء ميركة سور في محافظة أربيل
Authors: Mohammed Al Mamouri Mohammed Khalil 
Published: January 2023

تناولت هذه الدراسة الوضع الراهن والكشف عن التغير في الغطاء النباتي في قضاء ميركة سورمن خلالا لاستفادة من تكامل تقنيتي الاستشعار عن بعد (Remote Sensing) من مرئيات فضائية حديثة التي يزودها القمر الصناعي (Landsat 8) ونظم المعلومات الجغرافية (GIS) من خلال برنامجARC MAP 10.3 الذي يقوم بإجراء كثير من الوظائف كعمليات المعالجة الآلية للمرئيات الفضائية وتحليل وتفسير نوع التغير ومقداره ومساحته |، وقداعتمدت الدراسة على منهج توظيف المؤشرات الطيفية (NDVI) وذلك بهدف إنتاج خرائط رقمية للغطاء النباتي لأربع فصول لعام (2017) لمنطقة الدراسة لتحديد المناطق التي تغيرت سواء للزيادة أو النقصان و المناطق التي لم تتغير و إنشاء قاعدة بيانات عن حالة و مساحة الغطاء النباتي .
شملت الدراسة على ثلاث مباحث إذ ضم المبحث الأول الإطار النظري للبحث ، وتناول المبحث الثاني المقومات الطبيعية لمنطقة الدراسة ، بينما تركز المبحث الثالث على كشف وتحليل التغير في الغطاء النباتي في منطقة الدراسة و قد ختمت الدراسة بالاستنتاجات والتوصيات.
أظهرت نتائج الدراسة انه على الرغم من الفرق القليل بين القيم العظمى لمؤشر (NDVI) بين كل من الفصول (الشتاء ، الربيع ،الصيف ، الخريف ) ألاان الفرق كان كبيرا عند مقارنة قيم الوسط الحسابي لمؤشر (NDVI) بين الفصول الأربعة ، وهو دليل على تباين الانعكاسية الطيفية للنبات وانخفاض كثافة وخضرة النبات في منطقة الدراسة.
كما وصت الدراسة بالاهتمام بتقنيات الاستشعار عن ونظم المعلومات الجغرافية وبرامج المعالجة الرقمية لمعالجة المعطيات الفضائية وللخروج بنتائج دقيقة ومرضية في الدراسات الجغرافية المختلفة
التجربة الاقتصادية الاشتراكية والخطط التنموية في تونس 1962– 1970
Authors: Hamad Al-Mashhadani Muayad Mahmoud , Taha Ghailan Sameer 
Published: January 2023

لا شك أن البناء الصحيح لأية دولة يتطلب قاعدة اقتصادية صلبة تؤسس عليها مؤسسات الدولة، ولا يمكن فصل الجانب السياسي عن الجانب الاقتصادي. حول الاستقرار السياسي للبلاد اهتمت تونس منذ استقلالها عام 1956 ببناء هيكل اقتصادي قوي من أجل استكمال البناء السليم لدولتها الحديثة، لا سيما وأن تونس كانت محصنة في ظل نظام الحماية الفرنسي الذي استنزف اقتصادها لسنوات عديدة. وخاصة أنه منذ إعلان النظام الجمهوري في تونس عام 1957، أخذت الحكومة التونسية على عاتقها بناء بلد حديث على الطراز الغربي.
كان من المؤكد أن خطط التنمية وبناء الأسس الاقتصادية والهيكلية هي أول ما بدأت الحكومة التونسية في تقوية وتقوية اقتصادها لدعم مشروع التحديث الجديد الذي تبنته بعد تولي الحبيب بورقيبة مقاليد الحكم، إذ أعلن عددًا من إصلاحات في مختلف قطاعات ومؤسسات الدولة، ولعل أبرزها الجانب الاقتصادي.