bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood safety, fall indices, physical activity level and social participation restrictions from a population of community-dwelling older adults in Nsukka, Enugu State, Nigeria
Authors: Akosile Christopher Olusanjo , Ngwu Nnaemeka Pascal , Okonkwo Uchenna Prosper , Onwuakagba Ifeoma Uchenna , Okoye Emmanuel Chiebuka 
Published: June 2023

Abstract
Background
Restriction in physical activity (PA) and social participation restriction (PR) can be heightened in the presence of fear of fall (FOF), fall experience, and perceived unsafe neighborhood, particularly among older adults. Despite the enormous benefits of social participation and physical activity, many older adults remain vulnerable to participation restriction and this probably accounts for a significant proportion of health challenges for older adults.

Objective
This study investigated the relationship between neighborhood safety (NS), fall indices, physical activity, and social participation restriction among older adults from selected communities in Nsukka, Enugu state, Nigeria.

Methods
This was a cross-sectional survey of 170 recruited via consecutive non-probability sampling techniques. Socio-demographic variables, co-morbidities, and fall prevalence were obtained using a self-administered questionnaire. The study instruments include the PA neighborhood environment scale – Nigeria (PANES-N), PA scale for elderly (PASE), Participation scale (PS), Modified fall efficacy scale (MFES), and Fall risk assessment tool (FRAT) and fall indices.

Statistical analysis
Descriptive statistics of mean and standard deviations, frequency counts, and percentages were used to analyze the socio-demographic variables, and Inferential statistics of Spearman rank order correlation were used to determine the relationship among the neighborhood safety, fall indices, physical activity level, and participation restrictions.

Results
PR has a negative relationship with NS (r = -0.19, p- 0.01), and fall efficacy (r = -0.52, p- 0.001). However, PR has a positive relationship with fall risk (r = 0.36, p = 0.001).

Conclusion
Participation restriction is negatively correlated with neighborhood safety, fall efficacy, and PA. The PR has a positive relationship with fall risk (FR).
Biological activities of extracts and compounds from Thai Kae-Lae (Maclura cochinchinensis (Lour.) Corner)
Authors: Rueankham Lapamas , Panyajai Pawaret , Saiai Aroonchai , Rungrojsakul Methee , Tima Singkome , Chiampanichayakul Sawitree , Yeerong Kankanit , Somwongin Suvimol , Chaiyana Wantida , Dejkriengkraikul Pornngarm , Okonogi Siriporn , Katekunlaphan Trinnakorn , Anuchapreeda Songyot 
Published: June 2023

AbstractBackground and aimsThe purpose of this study was to investigate the biological properties of Kae-Lae (Maclura cochinchinensis(Lour.) Corner), a traditional medicinal plant used in Ayurvedic recipes in Thailand. To achieve this objective, heartwood samples were collected from 12 sources across Thailand. Fractional extracts (n-hexane, ethyl acetate, and ethanol) and the dominant compounds (morin, resveratrol, and quercetin) were examined for their abilities on cytotoxicity, antioxidant, anti-inflammation, and antileukaemic activity (Wilms’ tumour 1 protein was used as a well-known biomarker for leukaemic cell proliferation).MethodsThe study used MTT to assess cytotoxicity in leukaemic cells (K562, EoL-1, and KG-1a). Antioxidant activities were evaluated using ABTS, DPPH, and FRAP assays. The anti-inflammatory activity was investigated by detecting IL-2, TNF-α, and NO using appropriate detection kits. Wilms’ tumour 1 protein expression was measured by Western blotting to determine the anti-leukaemic activity. The inhibition of cell migration was also analyzed to confirm anticancer progression.ResultsAmong the tested extract fraction, ethyl acetate No. 001 displayed strong cytotoxicity specifically in EoL-1 cells, whilen-hexane No. 008 demonstrated this effect in three cell lines. Resveratrol, on the other hand, displayed cytotoxicity in all the tested cells. Additionally, the three major compounds, morin, resveratrol, and quercetin, exhibited significant antioxidant and anti-inflammatory properties. In particular, resveratrol demonstrated a noteworthy decreased Wilms’ tumour 1 protein expression and a reduction in cell proliferation across all cells. Moreover, ethyl acetate No. 001, morin, and resveratrol effectively inhibited MCF-7 cell migration. None of these compounds showed any impact on red blood cell haemolysis.ConclusionBased on these findings, it can be concluded that Kae-Lae has promising chemotherapeutic potential against leukaemic cells, with fractional extracts (ethyl acetate andn-hexane) and resveratrol exhibiting the most potent cytotoxic, antioxidant, anti-inflammatory, and anti-cell migration activities.
Unani Tibb practitioners’ perceptions and attitudes towards spirituality and spiritual care in Unani Tibb practice in South Africa
Authors: Hoosen Mujeeb , Roman Nicolette Vanessa , Mthembu Thuli Godfrey , Naseer Mursaleen 
Published: June 2023

Abstract
Background
Unani Tibb is an Arabic term which means Greek medicine. It is an ancient holistic medical system based on the healing theories of Hippocrates, Galen and Ibn Sina (Avicenna). Despite this, spirituality and spiritual care practices are deficient in the clinical setting.

Methods
This cross-sectional descriptive study was used to describe Unani Tibb practitioners’ perceptions and attitudes regarding spirituality and spiritual care in South Africa. A demographic form, Spiritual Care-Giving Scale, Spiritual and Spiritual Care Rating Scale and Spirituality in Unani Tibb Scale were used to collect data.

Results
A response rate of 64.7% (n = 44 out of 68) was achieved. Positive perceptions and attitudes regarding spirituality and spiritual care were recorded for Unani Tibb practitioners. The spiritual needs of their patients were considered vital towards enhancing the Unani Tibb treatment approach. Spirituality and spiritual care were regarded as fundamental to Unani Tibb therapy. However, most practitioners agreed that adequate training in spirituality and spiritual care was lacking and future training initiatives were imperative for Unani Tibb clinical practice in South Africa.

Conclusion
The findings of this study recommends further research in this field by means of qualitative and mixed methods approaches to provide a deeper understanding to this phenomenon. Clear guidelines on spirituality and spiritual care for Unani Tibb clinical practice are essential to ensure the integrity of the holistic approach required by the profession.
Validation of the accident and emergency experience questionnaire: a cross-sectional survey
Authors: Wong Eliza Lai-Yi , Cheung Annie Wai-Ling , Qiu Hong , Ma Jonathan Chun-Hei , Yeoh Eng-Kiong 
Published: June 2023

Abstract
Background
Patient feedback is an important way for healthcare providers to understand patient experience and improve the quality of care effectively and facilitate patient-centered care in the healthcare system. This study aimed to suggest a validated instrument by evaluating the psychometric properties of the Accident and Emergency Experience Questionnaire (AEEQ) for measuring patient experience in the accident and emergency department (AED) service among the adult Chinese population.

Methods
Attendances aged 18 or above from all public hospitals with AEDs during 16–30 June 2016 were targeted and a cross-sectional telephone survey was conducted using AEEQ. Preliminary AEEQ consisted of 92 items, including 53 core evaluative items and 19 informative items, and the other 20 items covered socio-demographics, self-perceived health status, and free open-ended comments on AED service. Psychometric properties of the evaluative items were evaluated for practicability, content and structure validity, internal consistency, and test-retest reliability in this study.

Results
A total of 512 patients were recruited with a response rate of 54% and a mean age of 53.2 years old. The exploratory factor analysis suggested removing 7 items due to weak factor loadings and high cross-loading and then leaving 46 items grouped into 5 dimensions, which were care and treatment (14 items), environment and facilities (16 items), information on medication and danger signals (5 items), clinical investigation (3 items), and overall impression (8 items) to represent patient experience on AED service. The internal consistency and test-retest reliability were high with Cronbach’s alpha coefficient and Spearman’s correlation coefficient of the suggested scale of 0.845 and 0.838, respectively.

Conclusion
The AEEQ is a valid and reliable instrument to evaluate the AED service which helps to build the engagement platform for promoting patient-centered care between patients and frontline healthcare professionals and improving healthcare quality in the future.
Severe congenital neutropenia due to G6PC3 deficiency: early and delayed phenotype of a patient
Authors: Moradian Negar , Zoghi Samaneh , Rayzan Elham , Seyedpour Simin , Jimenez Heredia Raul , Boztug Kaan , Rezaei Nima 
Published: June 2023

Abstract
Background
Severe Congenital Neutropenia type 4 (SCN4), is a rare autosomal recessive condition, due to mutations in the G6PC3 gene. The phenotype comprises neutropenia of variable severity and accompanying anomalies.

Case presentation
We report a male patient with confirmed G6PC3 deficiency presented with recurrent bacterial infections and multi-systemic complications. Our case was the first with a novel homozygous frameshift mutation in G6PC3. The patient demonstrated large platelets on his peripheral blood smear which is a rare presentation of this disease.

Conclusion
As SCN4 patients could be easily missed, it is recommended to consider G6PC3 mutation for any case of congenital, unexplained neutropenia.
Emotional neglect and parents’ adverse childhood events
Authors: Ylitervo Laura , Veijola Juha , Halt Anu-Helmi 
Published: June 2023

Abstract

Introduction
Emotional neglect means that the child’s emotional and developmental needs are not fulfilled by the parents or other caregivers. Adverse childhood events (ACEs) are a risk factor for mental health problems and impaired parenting skills. The objective here was to examine whether parents’ ACEs increase the child’s risk of experiencing emotional neglect.

Methods
The participants in the present study were members of the Northern Finland Birth Cohort 1986 (NFBC1986). Emotional neglect experiences were measured in 190 members of this cohort by means of the Trauma and Distress Scale (TADS), and ACEs in both parents were measured with a specific questionnaire. A linear regression model was used to examine the association between parents’ ACEs and the children’s emotional neglect scores.

Results
The children’s mean emotional neglect score was 8.11 on a scale from 5 to 25. There was no significant difference between males (mean 8.01) and females (mean 8.19). Only father’s ACEs were associated with child’s emotional neglect score. In the linear regression model, the children’s emotional neglect scores increased by 0.3 points for father’s ACE.

Conclusions
Our findings suggest that father’s ACEs may increase the child’s risk of experiencing emotional neglect. It seems that childhood adversities are transferred from parents to children, but larger samples would be needed to confirm these findings.
Opportunities and challenges of self-binding directives: A comparison of empirical research with stakeholders in three European countries
Authors: Scholten Matthé , Efkemann Simone A. , Faissner Mirjam , Finke Marleen , Gather Jakov , Gergel Tania , Gieselmann Astrid , van der Ham Lia , Juckel Georg , van Melle Laura , Owen Gareth , Potthoff Sarah , Stephenson Lucy A. , Szmukler George , Vellinga Astrid , Vollmann Jochen , Voskes Yolande , Werning Anna , Widdershoven Guy 
Published: June 2023

AbstractBackgroundSelf-binding directives (SBDs) are psychiatric advance directives that include a clause in which mental health service users consent in advance to involuntary hospital admission and treatment under specified conditions. Medical ethicists and legal scholars identified various potential benefits of SBDs but have also raised ethical concerns. Until recently, little was known about the views of stakeholders on the opportunities and challenges of SBDs.AimsThis article aims to foster an international exchange on SBDs by comparing recent empirical findings on stakeholders’ views on the opportunities and challenges of SBDs from Germany, the Netherlands, and the United Kingdom.MethodComparisons between the empirical findings were drawn using a structured expert consensus process.ResultsFindings converged on many points. Perceived opportunities of SBDs include promotion of autonomy, avoidance of personally defined harms, early intervention, reduction of admission duration, improvement of the therapeutic relationship, involvement of persons of trust, avoidance of involuntary hospital admission, addressing trauma, destigmatization of involuntary treatment, increase of professionals’ confidence, and relief for proxy decision-makers. Perceived challenges include lack of awareness and knowledge, lack of support, undue influence, inaccessibility during crisis, lack of cross-agency coordination, problems of interpretation, difficulties in capacity assessment, restricted therapeutic flexibility, scarce resources, disappointment due to noncompliance, and outdated content. Stakeholders tended to focus on practical challenges and did not often raise fundamental ethical concerns.ConclusionsStakeholders tend to see the implementation of SBDs as ethically desirable, provided that the associated challenges are addressed.
Trifluridine/tipiracil (FTD/TPI) in extensively pre-treated metastatic colorectal cancer (mCRC) patients: Evaluation of prognostic subgroups of the TALLISUR study.
Authors: Karthaus Meinolf , Weiss Lena , Riera-Knorrenschild Jorge , Kretzschmar Albrecht , Welslau Manfred , Vehling-Kaiser Ursula , Pelz Henning , Ettrich Thomas Jens , Held Swantje , Kehrmann Linde , Hess Juergen , Reislaender Timo , Heinemann Volker 
Published: June 2023

3556 Background: Compared to placebo, FTD/TPI significantly improved overall survival (OS) in patients (pts) with pre-treated mCRC in the pivotal phase III RECOURSE trial. Subgroup analyses indicated that all subgroups benefitted from FTD/TPI. Of note, FTD/TPI prolonged survival even more in pts ≥ 65 years old. To evaluate these observations with data from daily clinical practice, we performed a subgroup analysis of the TALLISUR study. Methods: In this prospective, multi-center, German, open-label, phase IV study, pts with extensively pre-treated mCRC chose between best supportive care (BSC) or oral FTD/TPI (35 mg/m2 bid on days 1 – 5 and 8 – 12 of each 28-day cycle). Duration of treatment and OS were analyzed for various subgroups. Based on a post-hoc analysis of the RECOURSE trial, 3 subgroups were defined according to: best, good and poor prognostic characteristics (BPC, GPC, PPC). Pts with < 3 metastatic sites at inclusion and ≥ 18 months from diagnosis to inclusion were considered to have GPC. GPC pts without liver metastasis at inclusion were considered to have BPC. All remaining pts were considered to have PPC. Results: Of 195 eligible pts, 186 pts chose treatment with FTD/TPI, while 9 pts decided to receive BSC only. Median OS was 6.9 (95% CI 6.1 – 8.3) months. Mean duration of treatment with FTD/TPI was 14.6 (range 0.1 – 102.7) weeks. Results of the subgroup analysis are summarized in the table. Pts ≥ 65 years old presented a longer median OS (7.2 vs 6.2 months). Conclusions: When given the choice between treatment and BSC in late-stage CRC, the vast majority of pts opted for treatment. Low metastatic burden and indolent disease were factors of good prognosis for FTD/TPI therapy regarding OS. Independent of baseline characteristics such as age, sidedness, and time of onset of metastases, virtually all pts benefitted from therapy with FTD/TPI. Albeit not statistically significant, elderly pts tend to have improved survival with FTD/TPI, consistent with results from RECOURSE. Clinical trial registration number: EudraCT No 2017-000292-83 . [Table: see text]
“Mine from ’33; Yours from ’41”
Authors: Glaser Amelia M. 
Published: June 2023

AbstractAt many points in modern history, Ukrainian identity has been bound up with the Ukrainian language, Ukrainian forms of Christianity, and specific collective experiences of trauma as Ukrainians. This sense of national identity was particularly felt in the immediate post-Soviet period; for although Soviet nationalities policy attempted to eradicate dangerous forms of nationalism and ethnic prejudice, these policies often had the reverse effect, creating a heightened sense of competition between individual ethnic groups, which persisted into the post-1991 reconstruction of East European borders. In the wake of the 2013–14 Euromaidan protests, poets in Ukraine have sought to correct the failures of both Soviet nationalities policy and post-Soviet Ukrainian national-identity formation by weaving Jewish, Ukrainian, and Crimean Tatar histories of collective trauma into their writing. This article focuses on the recent work of the poet Marianna Kiyanovska, whose attempt to bridge seemingly irreconcilable histories can be read as part of what scholars have identified as a recent shift from viewing Ukrainian identity as an ethnic category to a civic one. Reading Kiyanovska in the context of other recent Ukrainian poems and songs, the author argues that this “civic turn” in Ukrainian identity formation is both a direct response to conversations taking place about the meaning of the Maidan, and part of a global conversation about privilege, erasure, and culpability.
Milton Friedman and Exchange Rates: History and Controversies
Authors: Edwards Sebastian 
Published: June 2023

AbstractThis article investigates how Milton Friedman's views on exchange rates in emerging nations evolved through time. Early on he supported flexible exchange rates for most less developed countries. He endorsed several forms of flexibility, including auctions and the “crawling peg.” Starting in the early 1970s, he favored a system characterized by fixed rates and no central banks. From that point on he argued that while flexible rates were the preferred option for advanced nations, they were the second-best solution for (most) developing countries. This article helps elucidate Friedman's views on the use of pegged exchange rates during stabilization programs (Chile and Israel) and on exchange rates in socialist countries (China and Yugoslavia).
Cameralism in Practice and Prussian Industrialization Policies
Authors: Zhao Xuan 
Published: June 2023

AbstractThis article argues that Prussian industrialization policies implemented by Peter Beuth and Christian Rother from 1820 to 1848 worked as a kind of cameralism in practice. This argument is supported by two main points: first, Beuth, the primary Prussian industrialization promoter, was a cameralist who, having been trained in cameral sciences at university, tried to apply what he was taught to his industrial policy; second, Beuth's and Rother's industrialization policies accorded with the cameralist way of thinking in creating and promoting new manufacturing industries. Their ideologies were especially similar to that of J. H. G. Justi, the epitome of eighteenth-century cameralism. This article tries to challenge the “disordered police state” interpretation of cameralism and argues that, in contrast to such critical assessments, the economic strategy of cameralism could be interpreted as “the ride of Pegasus.”
Provincializing Trans Studies
Authors: Sharma Shiv Datt 
Published: June 2023

Abstract
In this short essay, the author calls for a provincialization of trans studies by rethinking the framework of the liberal humanist ontological self as the given basis for understanding trans experience. Briefly describing the neglect of non-Western epistemologies and practices in canonical trans studies in the United States, the author argues that turning our attention to these modes of selfhood, identity, and embodiment, such as conceived within hijra cultures in India, would be useful in lending productive directions for future work within the field. The author suggests that this work should be undertaken not with the sole purpose of expanding the geographic contours of the field, but in the spirit of destabilizing and de-essentializing what the signifier trans itself represents.
Crystal Labeija, Femme Queens, and the Future of Black Trans Studies
Authors: Ultra Omni Victor 
Published: June 2023

Abstract
This short essay springs from the question, Why has trans studies sustained a silence around Black elders in general, and Black femme queens in particular? The author reflects on the interventions of current scholars in Black trans studies and their import to the historicization of the house/ball culture or house-structured ballroom scene. Through a Black feminist imperative, this essay calls on trans studies to refuse the necropolitical logics that assume all the progenitors of the ballroom scene have died. In revisiting the rich cultural archive of the house-structured ballroom scene, such as the 1982 film T.V. Transvestite, this article reminds the reader that Black trans studies remains an archeological project.
Program for a Transgender Existentialism
Authors: Haulotte Penelope 
Published: June 2023

Abstract
Trans theory is characterized in part by the apparent tension between discursive analyses of cisgender society and phenomenological descriptions of trans experiences. While traditional inquiry into the history of philosophy proposes an interminable opposition between phenomenology and discourse analysis, Henry Rubin's alternative suggestion is that within the domain of trans studies these methods are complementary. Discourse analysis and phenomenology converge in trans studies because they are submitted to the same ethical and political imperative: the systematic development of the trans archive. Both discourse analysis and phenomenology as methods in trans studies are directed toward the development of a genuinely trans history, perspective, and theory, with special methodological consideration of the way that this perspective is misunderstood or obscured by dominant frameworks within cisgender society. In what follows, the author provides a brief reconstruction of two major interventions in trans phenomenology, demonstrating that each is carefully concerned with distinctly archival considerations. The author further argues that each project remains unfinished because of an incomplete bracketing of medicalized cisgender concepts. The article then proposes a brief alternative program aimed at the full suspension of cisgender categories that the author calls transgender existentialism.
Trans* Poetics in Translation
Authors: Rose Liz 
Published: June 2023

Abstract
In their poem “I, Monster Mine” (“Yo monstruo mío”) Argentine activist and self-proclaimed trans* sudaca artist Susy Shock demands the right to be “whatever my pinche desire fucking feels like.” By centering desire, Shock's poem echoes contemporary feminist theorizing in Argentina and calls into question the construction of normative human subjects via the semantic claim to the word monster, yet evades recourse to global North theories of trans* subjectivity.