bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-Specific Optimal Target Blood Pressure for the Primary Prevention of Hemorrhagic Stroke: A Nationwide Observational Study
Authors: Shim Hwan Seok , Park Jeong Mee , Lee Yong Jae , Kim Young Deok , Kim Tackeun , Ban Seung Pil , Bang Jae Seung , Kwon O-ki , Oh Chang Wan , Lee Si Un 
Published: January 2023

Abstract
There arefew reports on the preventative value of intensive blood pressure (BP) management for stroke, especially hemorrhagic stroke (hSTK),after new criteria for hypertension (HTN) were announced by theAmerican College of Cardiology/American Heart Association in 2017. To identify the optimal BP for the primary prevention of hSTK in a healthy population aged between 20 and 65 years, we conducted a 10-yearobservational study on the risk of hSTK, subclassified as intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) according to BP categories (e.g.,low normal BP, high normal BP, elevated BP, stage 1 HTN and stage 2 HTN) using the National Health Insurance Service Database. Of the 8,325,579 participants who had a health checkup in 2008, 947,378 were ultimately enrolled in this study and observed from 2009 to 2018. The risk of ICH was significantly increased from stage 2 HTN (adjusted hazard ratio (AHR) 2.002 [95% confidence interval (CI) 1.203-3.332]) and stage 1 HTN (AHR 2.021 [95% CI, 1.251-3.263]) in men and women, respectively. The risk of SAH was significantly increased among both men (AHR 1.637 [95% CI, 1.066-2.514]) and women (AHR 4.217 [95% CI, 2.648-6.715]) from stage 1 HTN. The risk of hSTK was significantly increased among men with stage 2 HTN (AHR 3.034 [95% CI, 2.161-4.260]) and women with stage 1 HTN (AHR 2.976 [95% CI, 2.222-3.986]).Therefore, for the primary prevention of hSTK, including ICH and SAH, adults under the age of 65 should manage their BP from stage 1 HTN.
Expanding The Role of PSMA PET for Active Surveillance
Authors: Jain Anika , Nassour Anthony-Joe , Dean Thomas , Patterson Imogen , Tarlinton Lisa , Kim Lawrence , Woo Henry 
Published: January 2023

Abstract
Introduction:
Accurate grading at the time of diagnosis is fundamental to risk stratification and treatment decision making, particularly for men being considered for Active Surveillance (AS). With the introduction of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) there has been considerable improvement in sensitivity and specificity for the detection and staging of clinically significant prostate cancer. Our study aims to determine the role of PSMA PET/CT in men with newly diagnosed low or favourable intermediate risk prostate cancer to better select men for AS.
Method:
This is a retrospective single centre study performed from January 2019 and October 2022. This study includes men identified from electronic medical record system who had undergone a PSMA PET/CT following newly diagnosed low or favourable-intermediate risk prostate cancer. Primary outcome was to assess the change in management for men being considered for AS following PSMA PET/CT results on the basis of PSMA PET characteristics. The study is approved (AHCL/HREC/2022-008) by the Adventist HealthCare Limited (AHCL) Human Research Ethics Committee (HREC).
Results:
In total, there were 11 of 30 men (36.67%) who were assigned management by AS and 19 of 30 men (63.33%) who required further treatment. 15 of the 19 men that needed treatment had concerning features on PSMA PET/CT results. Of the 15 men with concerning features on PSMA PET, 9 (60%) men were found to have adverse pathological features on final prostatectomy features.
Conclusion:
This retrospective study suggests that PSMA PET/CT has potential to influence the management of men with newly diagnosed prostate cancer that would otherwise be appropriate for active surveillance.
The effects of exercise therapy feedback on subjective treatment outcome and patient satisfaction: study protocol for a mono-centric, randomized, controlled trial in orthopedic rehabilitation (FeedYou)
Authors: Schuber André Arik , Schmidt Sebastian , Hombach Sarah , Schaller Andrea 
Published: January 2023

Abstract
Background: The disease burden of musculoskeletal disorders necessitates multidisciplinary and patient-centered models of care. Exercise therapy represents a first-line treatment strategy and a central component of medical rehabilitation. In order to realize the goals of long-term physical activity and participation as proposed by the ICF, exercise therapy can be supplemented by interventional techniques from the field of psychotherapy. Although psychotherapist feedback has been shown to improve therapeutic outcome and patient satisfaction, feedback use in exercise therapy is mostly limited to motor learning and exercise instruction. The present paper therefore describes the use of multidimensional exercise therapy feedback in medical rehabilitation. The aims of the trial presented in this study protocol are to evaluate the effects of this novel feedback approach on rehabilitation outcomes in comparison to usual care.
Methods: The study is designed as a prospective, mono-centric, randomized controlled, superiority trial (RCT) with two parallel groups and three measuring points: T0 = start of three-week inpatient rehabilitation, T1 = end of three-week inpatient rehabilitation, T2 = 12-week follow-up. In total, 132 patients suffering from chronic neck, shoulder and/or lumbar spine disorders will be recruited. The intervention involves multidimensional exercise therapy feedbacks during the initial and final physical therapist examination, as well as short exercise therapy feedbacks during the course units of the mandatory group-based exercise therapy program. Primary outcomes are the subjective treatment outcome, assessed by BPI and indication-specific questionnaires, as well as patient satisfaction, assessed by ZUF-8 and an intervention-specific questionnaire. The final data collection is expected by May 2023.
Discussion: This study may provide a valuable insight into the effectiveness of multidimensional exercise therapy feedback to improve treatment outcomes and patient satisfaction in medical rehabilitation. This could contribute to rehabilitation quality assurance and the long-term physical activity behavior of rehabilitation patients. Trial registration: The trial has been registered with the German Clinical Trial Register (DRKS) under the registration number DRKS00027263.
Trial registration: The trial has been registered with the German Clinical Trial Register (DRKS) under the registration number DRKS00027263.
Identification and validation of RAB2A as a new prognostic biomarker for breast cancer
Authors: Lin Shenguo , Mao Yiwen , Hu Chengda , Lv Rui , Zeng Hongdou , Zhang Minghao , Wu Xinlei , Lin Lizi , Ouyang Shanshan , Zhao Yaxin 
Published: January 2023

Abstract
Background: Targeting GTPase 2A(RAB2A) is overexpressed in a variety of malignancies and plays an essential role in tumor formation. However, the predictive significance of RAB2A in breast cancer remains undetermined.
Methods:In this study, breast cancer patients' expression profiles and clinical data were extracted from The Cancer Genome Atlas (TCGA) database. Using the Wilcoxon rank sum test, RAB2A expression levels were compared between breast cancer and normal breast tissue. An enrichment analysis was performed to investigate potential signaling pathways and associated biological activities. Using single-sample gene set enrichment analysis, the invasion of immune cells was evaluated. Utilizing Ualcan and the MethSurv database, the methylation status of RAB2A was determined. Using the Kaplan-Meier technique and Cox regression analysis, the prognostic value of RAB2A was determined. A nomogram was developed to predict overall survival (OS) one, three, and five years following cancer diagnosis.
Results: RAB2A was substantially linked with higher PR, ER status, N grade, histological type, PAM50, and age and was overexpressed in breast cancer.Overexpression of RAB2A significantly decreased overall survival and disease-specific survival. RAB2A was found as an independent negative predictive factor for OS by multivariate Cox analysis. The concordance index of the OS nomogram generated was 0.72. Similarly, RAB2A hypomethylation was related with a bad outcome. Analysis of functional enrichment revealed that keratinocyte development, humoral immune response pathway, IL-16 signaling pathway, cytokine-receptor interactions, immune response regulatory signaling pathway, and taste transduction were among the enriched pathways. In addition, RAB2A overexpression was negatively linked with the number of necrotizing cells, CD8+ T cells, dendritic cells, and plasmacytoid dendritic cells that infiltrated the tissue.
Conclucion:RAB2A may serve as a possible breast cancer prognostic biomarker and therapeutic target. Our findings establish the groundwork for future research into the molecular mechanisms of RAB2A in breast cancer and are essential for clarifying RAB2A's therapeutic relevance in breast cancer.
Blood pressure management strategy in patients with acute ischemic stroke after mechanical thrombectomy (CHASE-MT): A prospective, multicenter, randomized controlled, open-label clinical trial protocol
Authors: Zhao Hanghang , Guo Xin , Shi Rui , Wei Dong , Li Yang , Yuan Xingyun , Zhu Hao , Li Weiwang , Chang Mingze , Li Jiang , Di Zhengli , Lei Hui , Zhang Ru , Yang Xi'ai , Zhang Huiping , Zhang Bei , Shi Yajun , Kang Zhoucheng , Yang Fang , Li Li 
Published: January 2023

AbstractBackground The efficient control of blood pressure (BP) after mechanical thrombectomy (MT) has not been determined, and there is a lack of multicenter, prospective, randomized controlled, open-label clinical studies on the precise management of BP in patients with acute ischemic stroke (AIS) after undergoing MT. This trial aims to determine whether potent antihypertensive therapy (90–110 mmHg) effectively reduces the incidence of symptomatic hemorrhagic transformation at 48 h after MT and the incidence of poor prognosis at 90 days after therapy in patients with AIS. Methodology/Design: This is a randomized, controlled, open-label, prospective, multicenter clinical trial. Patients with AIS treated with MT will be screened. A total of 324 adult patients with AIS (National Institutes of Health Stroke Scale (NIHSS) score, 6–19 points) will be recruited from 11 sites located in Shaanxi and Gansu pration system. The primary outcome measure is the proportion of patients in the trial group with a good prognosis (modified Rankin scale (mRS) score ≤ 2 points) at 90 days after treatment compared with the control group. The secondary outcome measures are the incidence of sICH due to reperfusion injury within 48 h after therapy, NIHSS score at 48 h after therapy, and mRS score at 14 days after therapy in both groups. Demographic characteristics, relevant medical history, characteristics of the occluded vessels, perioperative treatment, and monitoring results will be collected from all study subjects. The relationship between BP levels in AIS patients at 48 after successful recanalization and symptomatic hemorrhagic transformation and clinical prognosis will be explored. Discussion The CHASE-MT trial will be a large multicenter study that actively explores BP management strategies in patients with AIS undergoing MT. This trial has the potential to address the persistent BP elevation or high postoperative BP variability after successful recanalization in patients with AIS and to provide optimal BP levels. Trial registration: This trial was registered at ClinicalTrials.gov (Identifier: NCT05282290, Date of registration: June 13, 2022).
Atomically Dispersed d10 s-block Au Boosts Photocatalytic 1e- Water Oxidation for Self-Cleaning, Sanitation and Safe Drinkable Water­­
Authors: Teng Zhenyuan , Yang Hongbin , Zhang Qitao , Cai Wenan , Lu Ying Rui , Kato Kosaku , Zhang Zhenzong , ding jie , Sun Han , Liu Sixiao , Wang Chengyin , Chen Peng , Yamakata Akira , Su Chenliang , Liu Bin , Teruhisa Ohno 
Published: January 2023

AbstractProviding affordable safe drinking water and universal sanitation poses a grand challenge especially after the global COVID-19 pandemic. In this work, we developed atomically dispersed Au on potassium-incorporated polymeric carbon nitride (AuKPCN) that could simultaneously boost photocatalytic generation of ·OH and H2O2with an apparent quantum efficiency over 90% at 400–420 nm. The introduction of potassium into the poly(heptazine imide) matrix formed strong K-N bonds, preventing Au from forming strong interactions with N. Instead, Au formed a bond with C, only having weak interactions with N on KPCN, which rendered Au with an oxidation number close to 0. The results ofin-situvibrational spectroscopy, isotopic experiments, transient absorption spectroscopy and time-dependent density functional theory (TDDFT) simulations revealed that the low-valent Au could append its 6s orbital into the band diagram of AuKPCN that formed a trapping level for generating highly localized holes under photoexcitation. These highly localized holes could boost the 1e−water oxidation reaction to form highly oxidative ·OH and simultaneously unbind the hydrogen atom in H2O molecule, which greatly promoted the hydrogenation process during the 2e−oxygen reduction reaction (ORR) to produce H2O2. The photogenerated ·OH on AuKPCN led to a more than 120-fold efficiency enhancement for visible-light-response superhydrophilicity as compared to that of the commercial TiO2. The onsite fixed-bed reactor under photo-illumination achieved a remarkable 132.5 LH2Om− 2day− 1water disinfection rate (lg6), which is about 30 times superior than the TiO2photocatalytic advanced oxidation process in the most ideal case (< 4 LH2Om− 2day− 1; lg4).
Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis
Authors: Guo Xingrong , Gao Yujiu , Yuan Yue , Wen Shu , Chen Yanghui , Zhang Zongli , Feng Ying , Ma Shinan , Hu Rong , Fang Chen , Ruan Xuzhi , Yuan Yahong , Fang Xinggang , Luo Chao , Meng Zongji , Wang Xiaoli 
Published: January 2023

Abstract
The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood. We assessed the role of ANGPTL8, a protein secreted by HCC cells, in hepatocarcinogenesis and the mechanisms through which ANGPTL8 mediates crosstalk between HCC cells and tumor-associated macrophages. Immunohistochemical, Western blotting, RNA-Seq and Flow cytometry analysis of ANGPTL8 were performed. A series of in vitro and in vivo experiments were conducted to reveal the role of ANGPTL8 in the progression of HCC. ANGPTL8expression was positively correlated with tumor malignancy in HCC, and high ANGPTL8 expression was associated with poor overall survival (OS) and disease-free survival (DFS). ANGPTL8 promoted HCC cell proliferation in vitro and in vivo, and ANGPTL8KO inhibited the development of HCC in both DEN-induced and DEN-plus-CCL4-induced mouse HCC tumors. Mechanistically, the ANGPTL8–LILRB2/PIRB interaction promoted polarization of macrophages to the immunosuppressive M2 phenotype in macrophages and recruiting immunosuppressive T cells. In hepatocytes, ANGPTL8-mediated stimulation of LILRB2/PIRB regulated the ROS/ERK pathway and upregulated autophagy, leading to proliferation of HCC cells. Our data support that ANGPTL8 has dual role of in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis.
Venetoclax consolidation in high-risk CLL treated with ibrutinib for ≥1 year achieves a high rate of undetectable MRD
Authors: Thompson Philip , Keating Michael , Ferrajoli Alessandra , Jain Nitin , Peterson Christine , Garg Naveen , Wang Sa , Jorgensen Jeffrey , Kadia Tapan , Bose Prithviraj , Pemmaraju Naveen , Short Nicholas , Wierda William 
Published: January 2023

Abstract
Patients receiving ibrutinib for CLL rarely achieve undetectable measurable residual disease (U-MRD), necessitating indefinite therapy, with cumulative risks of treatment discontinuation due to progression or adverse events. This study added venetoclax to ibrutinib for up to 2 years, in patients who had received ibrutinib for ≥ 12 months (mo) and had ≥ 1 high risk feature (TP53 mutation and/or deletion, ATM deletion, complex karyotype or persistently elevated β2-microglobulin). The primary endpoint was U-MRD with 10− 4 sensitivity (U-MRD4) in bone marrow (BM) at 12mo. Forty-five patients were treated. On intention-to-treat analysis, 23/42 (55%) patients improved their response to CR (2 pts were in MRD + CR at venetoclax initiation). U-MRD4 at 12mo was 57%. Best rate of U-MRD4 was 33/45 (73%); 23/32 stopped ibrutinib; 9 continued ibrutinib. At a median of 41 months from venetoclax initiation, 5/45 patients have progressed; none have died from CLL or Richter Transformation. In 32 patients with BM U-MRD4, peripheral blood (PB) MRD4 was analyzed every 6 months; 10/32 have had PB MRD re-emergence at a median of 13 months post-venetoclax. In summary, the addition of venetoclax in patients treated with ≥ 12mo of ibrutinib achieved high rate of BM U-MRD4 and may achieve durable treatment-free remission.
Assessing carbon cycle projections from simple and complex models under SSP scenarios
Authors: Melnikova Irina , Ciais Philippe , Boucher Olivier , Tanaka Katsumasa 
Published: January 2023

Abstract
Both full-fledged Earth System Models (ESMs) and simple climate models (SCMs) have been used to investigate climate change for future representative CO2 concentration pathways under the sixth phase of the Coupled Model Intercomparison Project. Here we explore to what extent complex and simple models are consistent in their carbon cycle response in concentration-driven simulations. Although ESMs and SCMs exhibit similar compatible fossil fuel CO2 emissions, ESMs estimate lower ocean carbon uptake than SCMs in the historical period and future scenarios. Besides, ESMs and SCMs deviate in their land carbon uptake estimates, but the differences are scenario-dependent. The differences are partly driven by a few model outliers (ESMs and SCMs). They can also be attributed to the procedure of constraining SCMs with historical observations that is not applied to ESMs. The differences in land uptake arise from the difference in the way land-use change emissions are calculated and different assumptions on how the carbon-concentration (ꞵ) and carbon-climate (γ) feedbacks are defined. The discrepancy in the ꞵ feedback may reflect the treatment of nitrogen limitation of biomass growth by ESMs. The discrepancy in the γ feedback may reflect its heterogeneous spatial nature in ESMs, i.e., the γ feedback drives a carbon source in the low latitudes but may drive either a sink or source in the high latitudes. The differences in ocean uptake, which are especially large in overshoot scenarios, may arise from the faster mixing of carbon from the surface to the deep ocean in SCMs than in ESMs. We call the attention of climate modeling groups to these potential areas of model improvement.
Season, Storage and Extraction Method Impact on the Phytochemical Profile of Terminalia Ivorensis
Authors: Moomin Aliu , Russell Wendy R. , Knott Rachel M. , Scobbie Lorraine , Mensah Kwesi Boadu , Adu-Gyamfi Paa Kofi Tawiah , Duthie Susan J. 
Published: January 2023

Abstract
Background: Terminalia ivorensis (TI) is used in West African ethnomedicine for the treatment of conditions including ulcers, malaria and wounds. Despite its widespread use, the phytochemical profile of TI remains largely undetermined. This research investigated the effects of extraction method, season, and storage conditions on the phytochemical composition of TI to contribute towards understanding the potential benefits.
Methods: TI bark was collected in September 2014, September 2018 and February 2018 during the rainy or dry seasons in Eastern Region, Ghana. Samples were extracted sequentially with organic solvents (petroleum ether, chloroform, ethyl acetate and ethanol) or using water (traditional). Metabolites were identified by liquid chromatography–mass spectrometry/mass spectrometry and compared statistically by ANOVA.
Results: A total of 82 different phytochemicals were identified across all samples. A greater yield of the major phytochemicals (44%; p<0.05) was obtained by water as compared with organic extraction. There was also a higher concentration of metabolites present in cold (63%; p<0.05) compared with hot water extraction. A significantly (p<0.05) higher number of phytochemicals were identified from TI collected in the dry (85%) compared to the rainy season (69%). TI bark stored for four years retained 84% of the major phytochemicals.
Conclusions: This work provides important information on composition and how this is modified by growing conditions, storage and method of extraction informing progress on the development of TI as a prophylactic formulation or medicine.
Allied Health Professionals’ experiences and views towards improving musculoskeletal services in the UK for patients with musculoskeletal and co-existing mental health conditions: a qualitative study
Authors: Maki Dana , Tehrany Rokhsaneh , Teixeira Maria J. C. , Chumak Tanya , Hoerz Christine 
Published: January 2023

Abstract
Background: Interplay between physical and mental health (MH) is widely recognised in patients with Musculoskeletal and co-existing MH conditions. Evidence suggests that psychological interventions improve outcomes and satisfaction in patients with physical conditions, however current healthcare models continue to separate physical and mental health care, as health services are fragmented. If the delivery of MH support could be facilitated by Allied Health Professionals (AHPs), such as physiotherapists and occupational therapists (OTs), this could be an effective, low-cost way to achieve routine integration. This study aimed to explore the experiences of UK physiotherapists and OTs working with patients with MSK and co-existing MH conditions and to understand views on improving MSK services.
Methods:This was an exploratory-descriptive qualitative study using semi-structured interviews. Participants were recruited via social media and professional organisations using purposeful sampling. Participants included registered UK physiotherapists or OTs within MSK settings who managed patients with MH conditions. Inductive thematic analysis was used, where single and double-level coding, single counting and inclusion of divergent cases were conducted to enhance methodological rigour.
Results: Three broad dimensions were identified. Dimension one referred to openness to provide MH support, with scope of practice and lack of confidence as themes. Dimension two described challenges, incorporating mental health stigma, the clinical environment, and limited experience. The third dimension referred to training, which identified the need for further training and strategies to implement as themes.
Conclusion: Many challenges to achieving optimal integration of physical and mental health care exist within MSK services. These challenges go beyond the need for additional training and knowledge acquisition and include departmental readiness such as funding, diary management, and supervision by senior colleagues/or psychologists, which need consideration in parallel to match the evolving needs of the MSK population.