bluuebunny/crossref_metadata_2025_split huggingface dataset:
An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety, tolerability, and immune biomarkers from limited case numbers
Authors: Olson Katherine E. , Abdelmoaty Mai M. , Namminga Krista L. , Lu Yaman , Obaro Helen , Santamaria Pamela , Mosley R. Lee , Gendelman Howard E. 
Published: May 2023

AbstractBackgroundThe clinical utility and safety of sargramostim has previously been reported in cancer, acute radiation syndrome, autoimmune disease, inflammatory conditions, and Alzheimer’s disease. The safety, tolerability, and mechanisms of action in Parkinson’s disease (PD) during extended use has not been evaluated.MethodsAs a primary goal, safety and tolerability was assessed in five PD patients treated with sargramostim (Leukine®, granulocyte–macrophage colony-stimulating factor) for 33 months. Secondary goals included numbers of CD4+T cells and monocytes and motor functions. Hematologic, metabolic, immune, and neurological evaluations were assessed during a 5-day on, 2-day off therapeutic regimen given at 3 μg/kg. After 2 years, drug use was discontinued for 3 months. This was then followed by an additional 6 months of treatment.ResultsSargramostim-associated adverse events included injection-site reactions, elevated total white cell counts, and bone pain. On drug, blood analyses and metabolic panels revealed no untoward side effects linked to long-term treatment. Unified Parkinson’s Disease Rating Scale scores remained stable throughout the study while regulatory T cell number and function were increased. In the initial 6 months of treatment, transcriptomic and proteomic monocyte tests demonstrated autophagy and sirtuin signaling. This finding paralleled anti-inflammatory and antioxidant activities within both the adaptive and innate immune profile arms.ConclusionsTaken together, the data affirmed long-term safety as well as immune and anti-inflammatory responses reflecting clinical stability in PD under the sargramostim treatment. Confirmation in larger patient populations is planned in a future phase II evaluation.Trial registration: ClinicalTrials.gov: NCT03790670, Date of Registration: 01/02/2019, URL:https://clinicaltrials.gov/ct2/show/NCT03790670?cond=leukine+parkinson%27s&draw=2&rank=2.
Overlapped Bayesian spatio-temporal models to detect crime spots and their possible risk factors based on the Opole Province, Poland, in the years 2015–2019
Authors: Drozdowski Rafał , Wielki Rafał , Tukiendorf Andrzej 
Published: May 2023

AbstractGeostatistical methods currently used in modern epidemiology were adopted in crime science using the example of the Opole province, Poland, in the years 2015–2019. In our research, we applied the Bayesian spatio-temporal random effects models to detect ‘cold-spots’ and ‘hot-spots’ of the recorded crime numbers (all categories), and to ascertain possible risk factors based on the available statistical population (demographic), socio-economic and infrastructure area characteristics. Overlapping two popular geostatistical models in the analysis, ‘cold-spot’ and ‘hot-spot’ administrative units were detected which displayed extreme differences in crime and growth rates over time. Additionally, using Bayesian modeling four categories of possible risk factors were identified in Opole. The established risk factors were the presence of doctors/medical personnel, road infrastructure, numbers of vehicles, and local migration. The analysis is directed toward both academic and police personnel as a proposal for an additional geostatistical control instrument supporting the management and deployment of local police based on easily available police crime records and public statistics.
The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury
Authors: Yi Yuxi , Lu Weiqing , Shen Lijun , Wu Yang , Zhang Zhen 
Published: May 2023

AbstractApproximately 60–80% of cancer patients treated with abdominopelvic radiotherapy suffer post-radiotherapy toxicities including radiation enteropathy and myelosuppression. Effective preventive and therapeutic strategies are lacking for such radiation injury. The gut microbiota holds high investigational value for deepening our understanding of the pathogenesis of radiation injury, especially radiation enteropathy which resembles inflammatory bowel disease pathophysiology and for facilitating personalized medicine by providing safer therapies tailored for cancer patients. Preclinical and clinical data consistently support that gut microbiota components including lactate-producers, SCFA-producers, indole compound-producers and Akkermansia impose intestinal and hematopoietic radio-protection. These features serve as potential predictive biomarkers for radiation injury, together with the microbial diversity which robustly predicts milder post-radiotherapy toxicities in multiple types of cancer. The accordingly developed manipulation strategies including selective microbiota transplantation, probiotics, purified functional metabolites and ligands to microbe-host interactive pathways are promising radio-protectors and radio-mitigators that merit extensive validation in clinical trials. With massive mechanistic investigations and pilot clinical trials reinforcing its translational value the gut microbiota may boost the prediction, prevention and mitigation of radiation injury. In this review, we summarize the state-of-the-art landmark researches related with radio-protection to provide illuminating insights for oncologists, gastroenterologists and laboratory scientists interested in this overlooked complexed disorder.
Performance of the procedure for ultra-rapid extraction and loop-mediated isothermal amplification (PURE-LAMP) method to detect malaria in Haiti
Authors: Vincent Jeanne Perpétue , Existe Alexandre Valcena , Komaki-Yasuda Kanako , Boncy Jacques , Kano Shigeyuki 
Published: May 2023

Abstract
Background
Malaria continues to cause burden in various parts of the world. Haiti, a Caribbean country, is among those aiming to eliminate malaria within a few years. Two surveys were conducted in Haiti during which we aimed to evaluate the performance of the simple and rapid procedure for ultra-rapid extraction–loop-mediated isothermal amplification (PURE-LAMP) method with dried blood spots as an alternative diagnostic method for malaria in the context of low to very low rates of transmission.

Methods
Febrile and afebrile people were recruited from three administrative divisions within Haiti: Nippes, Sud and Grand’Anse, during the summers of 2017 (early August to early September) and 2018 (late July to late August). Their blood samples were tested by microscopy, rapid diagnostic tests (RDT), PURE-LAMP and nested PCR to detect Plasmodium infection. Sensitivity, specificity, positive and negative predictive values and kappa statistics were estimated with the nested PCR results as the gold standard.

Results
Among 1074 samples analyzed, a positive rate of 8.3% was calculated based on the nested PCR results. Among febrile participants, the rates in 2017 and 2018 were 14.6% and 1.4%, respectively. Three positives were detected among 172 afebrile participants in 2018 by PURE-LAMP and nested PCR, and all three were from the same locality. There was no afebrile participants recruited in 2017. The PURE-LAMP, RDT and microscopy had respective sensitivities of 100%, 85.4% and 49.4%. All of the testing methods had specificities over 99%.

Conclusions
This study confirmed the high performance of the PURE-LAMP method to detect Plasmodium infection with dried blood spots and recommends its use in targeted mass screening and treatment activities in low endemic areas of malaria.
Investigating the effect of nanolime treatment on the drying kinetics of Clipsham limestone
Authors: Browne Dáire E. , Peverall Robert , Ritchie Grant A. D. , Viles Heather A. 
Published: May 2023

Abstract
Climate change poses an ever-increasing risk to our stone built heritage. Among conservation actions, the use of consolidant products is considered a possible response to this challenge, and the adoption of nanolimes has been widely studied showing promising results. However, while the effectiveness and method of application has been assessed, few studies have probed the changes in drying kinetics following treatment. In fact, a drastic alteration of the water transport might lead to further anomalies. This study investigates the influence of nanolimes dispersed in ethanol on the drying kinetics of Clipsham limestone using cavity ring-down spectroscopy. The degree of treatment was assessed by gravimetry, Raman spectroscopy, optical microscopy, colorimetry, optical profilometry and thin section analysis. Results showed an increase in the dry mass, observable colour changes and decrease in surface roughness. Small but reproducible increases were observed in the evaporation flux for phase I behaviour following treatment, however, no changes were observed in the total mass of water released or the phase II diffusivity. Determination of the activation energy associated with phase II drying was unchanged following treatment . These results indicate that following treatment there has been little-to-no change in the internal surfaces and structure of the stone to affect vapour transport.
Prognostic stratification based on HIF-1α signaling for evaluating hypoxia status and immune landscape in hepatocellular carcinoma
Authors: Zhuang Hongkai , Zhang Zedan , Chen Bo , Tang Chenwei , Chen Xinming , Tan Wenliang , Yang Lei , Xie Zhiqin , Ma Xiaowu , Wang Qingbin , Wang Bingkun , Shang Changzhen , Chen Yajin 
Published: May 2023

AbstractHepatocellular carcinoma (HCC) has a desmoplastic and hypoxic tumor microenvironment (TME), resulting in poor prognosis and treatment resistance. This study aimed to construct a novel prognostic classifier to investigate the degree of hypoxia and immune profiles in HCC. Patients with HCC from public databases were classified into three HIF-1α clusters according to 16 reported HIF-1α-related genes. Then, an HIF-1α score system was constructed based on nine overlapping differentially expressed genes (ODEGs) among various HIF-1α clusters. Then, an HIF-1α score system was constructed based on nine overlapping differentially expressed genes (ODEGs) among various HIF-1α cluster. Besides, oncologic pathways and immune infiltration profiles were also investigated among HCCs with different HIF-1α scores. The reliable predictive abilities of the HIF-1α score system for patients’ survival were impressively suggested by the significant C-indexes and ROC analysis. All enrolled tumors were divided into high-, medium-, and low-HIF-1α score groups. Compared with the other two groups, the high HIF-1α score group exhibited highest enrichment of multiple oncogenic pathways, such as TNF-α signaling via NF-кB, IL6-JAK-STAT3 signaling, mTORC1 signaling, MYC signaling, Hedgehog signaling. Notably, higher HIF-1α scores correlated with advanced immunosuppressive TME. Besides, tumors with high HIF-1α scores represented high non-response rate to transcatheter arterial chemoembolization (TACE) and immune checkpoint blockade (ICB). In conclusion, we developed a novel HIF-1α score system to distinguish HCC with different degree of hypoxia and immune infiltration profiles.
Fundamental concepts and the latest evidence for esophageal pressure monitoring
Authors: Shimatani Tatsutoshi , Kyogoku Miyako , Ito Yukie , Takeuchi Muneyuki , Khemani Robinder G. 
Published: May 2023

AbstractTranspulmonary pressure is an essential physiologic concept as it reflects the true pressure across the alveoli, and is a more precise marker for lung stress. To calculate transpulmonary pressure, one needs an estimate of both alveolar pressure and pleural pressure. Airway pressure during conditions of no flow is the most widely accepted surrogate for alveolar pressure, while esophageal pressure remains the most widely measured surrogate marker for pleural pressure. This review will cover important concepts and clinical applications for esophageal manometry, with a particular focus on how to use the information from esophageal manometry to adjust or titrate ventilator support. The most widely used method for measuring esophageal pressure uses an esophageal balloon catheter, although these measurements can be affected by the volume of air in the balloon. Therefore, when using balloon catheters, it is important to calibrate the balloon to ensure the most appropriate volume of air, and we discuss several methods which have been proposed for balloon calibration. In addition, esophageal balloon catheters only estimate the pleural pressure over a certain area within the thoracic cavity, which has resulted in a debate regarding how to interpret these measurements. We discuss both direct and elastance-based methods to estimate transpulmonary pressure, and how they may be applied for clinical practice. Finally, we discuss a number of applications for esophageal manometry and review many of the clinical studies published to date which have used esophageal pressure. These include the use of esophageal pressure to assess lung and chest wall compliance individually which can provide individualized information for patients with acute respiratory failure in terms of setting PEEP, or limiting inspiratory pressure. In addition, esophageal pressure has been used to estimate effort of breathing which has application for ventilator weaning, detection of upper airway obstruction after extubation, and detection of patient and mechanical ventilator asynchrony.
Sensor orientation of the TMD seismic network (Thailand) from P-wave particle motions
Authors: Pornsopin Patinya , Pananont Passakorn , Furlong Kevin P. , Sandvol Eric 
Published: May 2023

AbstractThe Thai Meteorological Department (TMD) seismic network began development in 2008. There are a total of 71 seismic stations consisting of 26 borehole stations and 45 surface stations currently installed. The three-component data from the TMD seismic network have been widely used in previous seismological studies. In a recent analysis, we have found that sensor orientation as reported in the site metadata is sometimes significantly incorrect, especially for borehole stations. In this study, we analyze P-wave polarization data from regional and teleseismic earthquakes recorded in the network to estimate the true instrument orientation relative to geographic north and compare that to station metadata. Of the 45 surface stations, we found that at present, ~ 82% are well oriented (i.e., aligned within 0–15° of true north). However, 8 sites have sensors misoriented by more than 15°, and some stations had a temporal change in sensor orientation during an upgrade to the seismic system with replacement of the sensor. We also evaluated sensor orientations for 26 TMD borehole seismic stations, from 2018 to the 2022. For many of the borehole stations, the actual sensor orientation differs significantly from the TMD metadata, especially at short-period stations. Many of those stations have sensor misorientations approaching 180°, due to errors in the ambient noise analysis calibration techniques used during installation. We have also investigated how this sensor misorientation affects previous seismic studies, such as regional moment tensor inversion of earthquakes sources and receiver function stacking. We have found that the large deviations in sensor orientation can result in erroneous results and/or large measurement errors. A cause of the orientation error for borehole sites could be a combination of strong background surface ambient seismic noise coupled with an incorrect reference instrument response.
Perovskite single-crystal thin films: preparation, surface engineering, and application
Authors: Zhang Zemin , Kim Wooyeon , Ko Min Jae , Li Yuelong 
Published: May 2023

AbstractPerovskite single-crystal thin films (SCTFs) have emerged as a significant research hotspot in the field of optoelectronic devices owing to their low defect state density, long carrier diffusion length, and high environmental stability. However, the large-area and high-throughput preparation of perovskite SCTFs is limited by significant challenges in terms of reducing surface defects and manufacturing high-performance devices. This review focuses on the advances in the development of perovskite SCTFs with a large area, controlled thickness, and high quality. First, we provide an in-depth analysis of the mechanism and key factors that affect the nucleation and crystallization process and then classify the methods of preparing perovskite SCTFs. Second, the research progress on surface engineering for perovskite SCTFs is introduced. Third, we summarize the applications of perovskite SCTFs in photovoltaics, photodetectors, light-emitting devices, artificial synapse and field-effect transistor. Finally, the development opportunities and challenges in commercializing perovskite SCTFs are discussed.
The effect of professional development on in-service STEM teachers’ self-efficacy: a meta-analysis of experimental studies
Authors: Zhou Xuan , Shu Lina , Xu Zhihong , Padrón Yolanda 
Published: May 2023

AbstractThis meta-analysis examined the effectiveness of teacher professional development (PD) training on improving in-service STEM teachers’ self-efficacy in the K-12 teaching context. Twenty-one articles yielded 48 effect size estimates, incorporating 1412 teachers in the final analyses. Results indicated that the overall effect size of PD training on K-12 STEM teachers’ self-efficacy was strong at g = 0.64 (p < 0.01). This review contributes to the STEM teacher self-efficacy literature and confirms the significant impact of PD on improving STEM teachers’ self-efficacy. Results regarding the impact of substantive PD characteristics provide policymakers and practitioners seeking to improve STEM teacher self-efficacy with information for improving PD. Recommendations for researchers are also discussed in the paper.
Knowledge mapping and visualization of current sarcopenia and cancer research: a bibliometric analysis
Authors: Mohammed Marwa , Li Jianan 
Published: May 2023

Abstract
Background
Cancer survivors face broad challenges in weight loss due to multiple factors. Sarcopenia prevalence among cancer survivors has a wide range and is associated with worse outcomes. Sarcopenia and cancer attract global attention. The use of bibliometrics analysis in this area of interest still needs to be identified. This study was performed to assess the global trends and patterns of sarcopenia and cancer-related scientific publications.

Methods
Web of Science (WOS) and articles indexed in Science Citation Index Expanded. VOS viewer (Leiden University, Leiden, Netherlands) and R-studio using bibliometrics and R package were used for quantitative analysis of the dataset (year of publications, number of publications, institutes, journals, total citations, H-index status, authors, hotspots of institutes, Keywords, research area, and funding sponsor.

Results
Our analysis extracted 384 publications from 172 journals written by 2525 authors from the Institute for Web of Science Core Collection database. Overall, 384 articles from the WOS database met the inclusion criteria. The number of published papers has risen since 2014. The results showed that Japan, China and the USA contributed the most to this field. Moreover, our results recognized future research trends and the current condition of sarcopenia and cancer research based on the top 10 most cited articles and the keyword analysis. Finally, the leading author's analysis demonstrated that Shen Xian from Wenzhou Medical University, China, Baracos and Vickie E from the University of Alberta, Switzerland, were the most productive, active, and influential authors.

Conclusion
Our study demonstrates a comprehensive and objective overview of the up-to-date status of sarcopenia and cancer research. These data would benefit scholars who need information on sarcopenia and cancer research. It would be a reference guide for researchers wanting to conduct additional studies related to the topic.
Nasal mucocutaneous leishmaniasis (MCL) with necrotizing granulomatous inflammation inducing cytotoxic T-cell lymphoma in a male Yemeni patient
Authors: Ibrahim Hamdi , Hamid Khairy Abd El , Aziz Tarek Abd El , Samir El bahwashy Ahmed , Khattab Hamed , Aaref Basma , Elsayed Essam 
Published: May 2023

AbstractLeishmaniasis is a protozoal infection transmitted by sandfly vector; there are three main types of leishmaniasis: cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). Herein, we present a case of endonasal mucocutaneous leishmaniasis in a 34-year-old Yemeni patient who presented with disfiguring nasal swelling associated with fever, a swab from the lesion and direct microscopic examination proved to have mucocutaneous leishmaniasis; he was successfully treated with intravenous antimonial stibogluconate, 1 month after treatment biopsy from the lesion revealed cytotoxic T-cell lymphoma, the purpose is to alert the physicians and otolaryngologists to consider leishmaniasis in the differential diagnosis of nasal granulomas and also to highlight the importance of early diagnosis of cancer in survivors of cutaneous leishmaniasis, especially in areas where cutaneous leishmaniasis is still highly prevalent, as the chronic local inflammation may disfigure the face if not recognized early and adequately treated; also, early cancer diagnosis can prevent mortality
Clinicopathological Characteristics and Outcomes of Anal Squamous Cell Carcinoma Patients With and Without HIV Infection in Sub-Saharan Africa
Authors: Mduma Emmanuel , Dharsee Nazima , Samwel Kandali , Mwita Chacha J. , Lidenge Salum J. 
Published: May 2023

PURPOSE In the past 20 years, the burden of anal cancer (AC) increased by 60% in the United States and over three-fold in Africa. Rates of AC have increased by 20× in people living with HIV and the highest (50×) in men with HIV who have sex with men. However, in sub-Saharan Africa (SSA) where HIV is endemic, data on clinicopathological characteristics and outcomes of patients with AC are lacking. To address this, we have investigated AC disease presentation, treatment outcomes, and its predictors in a cohort of patients who were either HIV-infected or HIV-uninfected in SSA. METHODS We conducted a retrospective cohort study of patients with anal squamous cell carcinoma (SCC) treated at Ocean Road Cancer Institute in Dar es Salaam, Tanzania from January 2014 to December 2019. Associations between the study outcomes and their predictors were analyzed using univariate and multivariate analysis models. RESULTS A total of 59 patients with anal SCC were retrieved and had at least 2-year follow-up. The mean age was 53.9 (standard deviation ±10.5) years. While none of the patients presented with stage I disease, 64.4% had locally advanced disease. HIV infection was the major comorbidity (64.4%). The rate of complete remission at the end of treatment was at 49% while the 2-year overall survival (OS) and local recurrence-free survival were 86.4% and 91.3%, respectively. Despite high HIV coinfection in the cohort, AC treatment outcomes were not significantly associated with HIV status. Disease stage ( P = .012) and grade ( P = .030) were significantly associated with 2-year OS. CONCLUSION Patients with anal SCC in Tanzania present mainly with locally advanced disease associated with high HIV prevalence. In this cohort, the SCC grade was independently associated with treatment outcomes unlike other factors such as HIV coinfection.