bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contraceptive methods among families at risk for Early Onset Dementia: Related Factors in a Colombian Population
Authors: Becerra‐Mateus Juan Camilo , Vasquez Daniel , Zuluaga Maria , Rassi Sofia , Gómez Manuela , Quintero Juan Felipe , Andrade‐Villegas Angela M , Madrigal Lucia , Niño David Fernando Aguillón , Lopera Francisco 
Published: January 2025

AbstractBackgroundThe Alzheimer’s Disease Colombian kindred is the world’s largest autosomal dominant cohort with Early Onset Familiar Alzheimer’s Disease (EOAD) due to a single genetic variant. These families have been studied for decades, identifying the disease progression from early subclinical stages to late dementia stages. Such cognitive and functional decline impacts the mental and physical well‐being of families and caregivers and to our knowledge, how being part of these families affects reproductive desire and contraception has not been studied. Therefore, we aim to explore if sociodemographic data, exposure to the dementia progression of relatives, and knowledge about EOAD is associated with reproductive desire and contraceptive practices in the Colombian kindred.MethodA cross‐sectional study using a web‐based questionnaire emphasizing socio‐economic status, educational background, relationship with affected relatives, knowledge about EOAD, reproductive health (marital status, number of children, desire to conceive), and contraception (and long‐acting contraceptive methods (LAC)), was sent to cognitively unimpaired individuals from the PSEN1‐E280A Colombian kindred. All responders were included (N = 191).ResultOf all, 58.6% were female, age rank goes from 18 to 47 years, 87% had any contraceptive method, only 29% of the participants had LACs, 2.6% of the participants would like to have children even if they were PSEN1‐E280A carriers, and 94% of the participants were interested in being part of genetic counseling programs. The use of LACs was associated with being single and considering that having a family member with EOAD had a negative impact on them. Not wanting to have children or not wanting more children after an unwanted pregnancy was associated with having lived with an EOAD patient, having a higher knowledge of the disease, being single, and considering that having a family member with EOAD had a negative impact on them.ConclusionThis exploratory study shows that the experience of being part of a family with EOAD can influence sexual and reproductive health. This may be mediated by knowledge about the disease and the experiences of each individual. Further studies on the effect of these factors and possible ways to intervene are needed.
Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Authors: Dogan Elif O. , Simonini Sean R. , Bouley James , Weiss Alexandra , Brown Robert H. , Henninger Nils 
Published: January 2025

ObjectiveApproximately 20% of familial cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Epidemiological data have identified traumatic brain injury (TBI) as an exogenous risk factor for ALS; however, the mechanisms by which TBI may worsen SOD1 ALS remain largely undefined.MethodsWe sought to determine whether repetitive TBI (rTBI) accelerates disease onset and progression in the transgenic SOD1G93A mouse ALS model, and whether loss of the primary regulator of axonal degeneration sterile alpha and TIR motif containing 1 (Sarm1) mitigates the histological and behavioral pathophysiology. We subjected wild‐type (n = 23), Sarm1 knockout (KO; n = 17), SOD1G93A (n = 19), and SOD1G93AxSarm1KO (n = 26) mice of both sexes to rTBI or sham surgery at age 64 days (62–68 days). Body weight and ALS‐deficit score were serially assessed up to 17 weeks after surgery and histopathology assessed in layer V of the primary motor cortex at the study end point.ResultsIn sham injured SOD1G93A mice, genetic ablation of Sarm1 did not attenuate axonal loss, improve neurological deficits, or survival. The rTBI accelerated onset of G93A‐SOD1 ALS, as indicated by accentuated body weight loss, earlier onset of hindlimb tremor, and shortened survival. The rTBI also triggered TDP‐43 mislocalization, enhanced axonal and neuronal loss, microgliosis, and astrocytosis. Loss of Sarm1 significantly diminished the impact of rTBI on disease progression and rescued rTBI‐associated neuropathology.InterpretationSARM1‐mediated axonal death pathway promotes pathogenesis after TBI in SOD1G93A mice suggesting that anti‐SARM1 therapeutics are a viable approach to preserve neurological function in injury‐accelerated G93A‐SOD1 ALS. ANN NEUROL 2025
Construction of Covalent Triazine Framework With D‐A1‐A2 Configuration via Post‐Modification for Photocatalytic Hydrogen Evolution
Authors: Yang Yong , He Wei , Song Dengmeng , Xie Fang , Li Jiaying , Li Jun , Wang Ning 
Published: January 2025

ABSTRACTA D‐A1‐A2 type covalent triazine framework (CTF) was prepared for the photocatalytic hydrogen evolution (HER). In the resulting CTF‐CZ‐Bpy2+, 9‐ethyl‐9H‐carbazole (CZ) group is used as the donor, triazine ring as the first acceptor, and cyclic diquat (Bpy2+) moiety as the second acceptor. Both experimental and theoretical results show that the D‐A1‐A2 structure significantly enhances the efficiency of photogenerated charge separation and transfer. As a result, CTF‐CZ‐Bpy2+ demonstrated outstanding photocatalytic HER activity with a yield rate of 31.1 mmol g−1 h−1, which is 7.8 times higher than that of nonfunctionalized CTF‐CZ‐Bpy.
Nitrilotriacetic Acid Assisted Preparation of NiCo Bimetallic Nitride/N‐Doped Carbon for Supercapacitor Electrode
Authors: Zhu Maiyong , Zhang Xun , Yang Yu , Luo Qiao , Li Songjun 
Published: January 2025

ABSTRACTTransition metal nitride has been proved to be an ideal supercapacitor electrode material, and how to synthesize high‐performance transition metal nitride‐based materials rapidly and stably becomes critical. Here, we complexed the polydentate organic small molecule nitrilotriacetic acid with the transition metals Ni2+ and Co2+ and nitrided them by pyrolysis of urea. Considering the influence of the structure and morphology of the material on its energy storage properties, we further added sodium citrate to the system to study its effect on the morphology and properties of the complex. The composite (Ni‐Co‐N/NC) prepared under the optimal sodium citrate addition has a high specific capacitance of 610 F g−1 at a current density of 1 A g−1, and the specific capacitance remains at 84.4% of the initial capacitance after 5000 cycles at 5 A g−1, which shows excellent cycling stability. The maximum energy density of the hybrid capacitor (Ni‐Co‐N/NC//AC ASC) assembled with activated carbon was 21.1 Wh·kg−1 at a power density of 250 W·kg−1, which shows a promising application in the field of energy storage.
Covalent Deposition of Diels–Alder Reaction on Polyester Fiber Surface and Its Enhancement Mechanism on SBS‐Modified Asphalt
Authors: Ren Denghui , Fan Shencheng , He Lu , Liu Yu , Deng Shilin , Luo Yating , Wang Peihui , Jin Xin , Li Jing 
Published: January 2025

ABSTRACTPolyester (PET) fibers offer excellent chemical stability, mechanical strength, and high‐temperature tolerance, making them promising for asphalt applications. However, their smooth, chemically inert surface limits interfacial bonding with asphalt, reducing the overall performance. To address this, a mild covalent deposition method was employed, utilizing a polydopamine and furfuryl amine crosslinking reaction to incorporate furan groups on PET fibers. This enabled the formation of a dense Diels–Alder (D–A) reactive crosslinking layer. Characterization revealed that this layer increased surface roughness, free energy, and active functional groups, improving wetting and interlocking with asphalt. Rheological tests showed enhanced performance in styrene–butadiene–styrene (SBS)‐modified asphalt composites, with a 7.73% increase in G* at 46°C and an 81.94% improvement in adhesion. Molecular dynamics simulations confirmed the enhanced interfacial interactions between DA‐PET fibers and SBS‐modified asphalt, providing insight into the mechanism behind the improvements. This study presents a novel approach for optimizing PET fiber performance in asphalt materials.
Controllable Fabrication of MnCo2O4@Polypyrrole@MXene Ternary Composites for Electromagnetic Wave Absorption
Authors: Cheng Shaojuan , Jia Rufeng , Yin Baolin , Shang Weipo , Liu Shaobing 
Published: January 2025

ABSTRACTNowadays, excessive microwave radiation has become one of the urgent factors affecting human health. To solve the negative effects, electromagnetic wave‐absorbing materials have gradually become indispensable applications. Here, MnCo2O4@polypyrrole (PPy)@MXene (MPM) ternary composites are successfully synthesized by the combination of hydrothermal synthesis, high‐temperature sintering, in situ polymerization method, and low‐temperature freeze drying. The synergistic effect between dielectric loss and magnetic loss of MnCo2O4, Ppy, and MXene is studied in detail, showing the prepared composites have excellent absorption properties. MPM‐1 exhibits minimum reflection loss (RLmin) of −62.99 dB at 16.04 GHz under the ultra‐thin thickness (1.21 mm, 50 wt%), and the effective absorption bandwidth (EAB) is 3.94 GHz (13.44–17.38 GHz) at 1.28 mm (50 wt%). The prepared MPM composites have ultra‐thin thickness, wide absorption bandwidth, and excellent microwave absorption properties, which are ascribed to the combination of dielectric loss, magnetic loss, and multiple reflection and scattering effects of core–shell structure. These composites can be used as a significant electromagnetic wave absorbing material, and provide a new research idea for the application of ternary composite materials in electromagnetic wave absorbing materials.
Historical rainstorm in Hong Kong on 7–8 September 2023: Diagnosis, forecasting and nowcasting
Authors: Tam Hiu Ching , He Yu‐Heng , Chan Pak Wai , Yu Shiwei , Mo Huisi , Su Hui , Hsiao Ling‐Feng , Gong Yangzhao 
Published: January 2025

AbstractOn 7–8 September 2023, Hong Kong was hit by a historical and record‐breaking rainstorm associated with the remnant of Tropical Cyclone Haikui (2311). The hourly rainfall recorded at the Hong Kong Observatory Headquarters once reached 158.1 mm, the highest since record began in 1884. The 24‐h rainfall even exceeded 600 mm in some parts of the territory. The historical rainstorm resulted in heavy flooding and landslides, bringing significant societal impact to Hong Kong. This paper aims to review this unprecedented heavy rain event from the aspects of diagnosis, forecasting and nowcasting. Early indicators of such events over Hong Kong with substantial lead time are limited from the dynamics and thermodynamics consideration, the numerical weather prediction models, given the present technology. The only indication may come from the climatologically extreme total precipitable water. While recent research of developing a regional risk‐based alerting system on the higher impact event of flooding associated with heavy rain might have potential to enhance the weather service, and emerging AI model showed some promising post‐simulations, predicting historical and record‐breaking rainstorms remains a challenge for operational weather forecasting and warning services.
Raindrop size distribution variability associated with size‐dependent advection in convective precipitation systems
Authors: Okazaki Megumi , Yamaguchi Kosei , Yanase Tomoro , Nakakita Eiichi 
Published: January 2025

AbstractRaindrop size distribution (DSD) is fundamental for understanding precipitation processes. This study utilized a two‐dimensional simulation with bin cloud microphysics parameterizations to investigate the spatiotemporal variability of DSDs owing to the influence of mesoscale circulation associated with the precipitation system. The simulated multicellular convection went through developing, mature, and dissipating stages, with updraft weakening and rainfall area expanding through these stages. The width of the DSD narrowed as rainfall weakened. In addition, a significant bimodal DSD was observed during the dissipating stage. Furthermore, we investigated the spatial distribution of the number density of raindrops corresponding to the maximum, local minimum, and local maximum of the significant bimodal DSD in the dissipating stage. According to the results, the raindrops constituting the maximum, local minimum, and local maximum followed different advection processes. This size‐dependent advection effect may have contributed to the bimodal DSD formation.
Systemic T‐cell and local macrophage interactions mediate granule size‐dependent biological hydroxyapatite foreign body reaction
Authors: Lin Yixiong , Zou Yang , Yang Jieting , Han Zongpu , Guo Xinyu , Gao Xiaomeng , Xu Jieyun , Gong Zhuohong , Li Ruizhi , Li Zhipeng , Huang Baoxin , Xiao Yin , Deng Feilong , Chen Zetao 
Published: January 2025

AbstractBiological hydroxyapatite (BHA) has been widely used in alveolar bone augmentation, while unfavorable outcomes can still be encountered. Among several reasons, we noticed a chaotic granule size application issue. The principle behind the choice of proper granule size mainly lies in the fitness of defect shape and size. However, granule size has been shown to elicit significant biological effects, with the underlying mechanisms still unknown. BHA granules of five different sizes were first prepared and characterized to investigate their biological effects. We found that the biomimetic porous structure of BHA gradually disappeared with decreasing size, affecting the structure of the blood clot fibrin network, leading to different local immune microenvironments and foreign body reactions (FBRs). Among them, <0.2 mm BHA granules completely lost their biomimetic porous structure and their fibrin network was loosened with strong immune response and strongest FBR. We found Gata3 (+)/Nfat3 (+) Th2 cells were recruited from activated systemic immune organs, inducing CD206 (+)/CD163 (low) M2 macrophages through direct contact with Ptprc‐Mrc1, thereby promoting their fusion to form foreign body giant cells leading to strong FBR. This study expanded the understanding of the size effect of BHA granules from a biological perspective and unveiled the mechanisms of systemic immune towards BHA mediated FBR, providing regulatory targets to improve bone regeneration outcomes.
The Association Between the Onset and Ending of Volunteering on Loneliness and Perceived Social Isolation Among Older Adults: Longitudinal Evidence From the German Ageing Survey
Authors: Richardson Avery , König Hans‐Helmut , Hajek André 
Published: January 2025

ABSTRACTBackgroundExisting literature explores the relationship between voluntary work, loneliness, and social isolation, but there is a lack of research on how the onset and cessation of voluntary work relate to loneliness and social isolation among older adults. Many in this population may discontinue volunteering due to various life circumstances, making it important to investigate the longitudinal significance of these transitions. This study aims to assess whether engaging in volunteer work during retirement age is associated with changes in loneliness and social isolation.MethodsLongitudinal data were obtained from Waves 5 (Year 2014) and 6 (Year 2017) of the German Ageing Survey, focusing on middle‐aged and older adults. The sample size (n = 6628) was limited to those aged 65 and above. Two groups were analyzed: the onset group, individuals who did not volunteer in 2014 but did by 2017 (188 individuals), and the cessation group, those who volunteered in 2014 but not by 2017 (307 individuals). Loneliness was assessed using the De Jong Gierveld tool, and perceived social isolation was measured using the Bude and Lantermann instrument. Asymmetric linear fixed effects (FE) regression analysis examined the associations.ResultsIn an asymmetric FE regression analysis that adjusted for a multitude of time‐varying covariates, an association was shown between the onset of volunteer work and decreases in loneliness (β = −0.07; p = 0.04) in older adults. In contrast, there was no significant association between the onset of voluntary work and changes in perceived social isolation. Also, there was no significant association between the cessation of volunteer work and changes in perceived social isolation or loneliness.ConclusionOur findings suggest that older adults who choose to volunteer may experience a decrease in self‐reported loneliness. Further longitudinal studies are needed to confirm our present findings.
Pandemic or “Plandemic”?: The Mediating Role of Epistemic Justification Strategies in the Relationship Between COVID‐19 Conspiracy Beliefs and COVID‐19 Vaccine Conspiracy Beliefs
Authors: Gökalp Ali , Üztemur Servet , Huang Po‐Ching , Kartol Aslı , Tsai Hsin‐Chi , Dinç Erkan , Griffiths Mark D. , Lin Chung‐Ying 
Published: January 2025

ABSTRACTBackgroundIn today's post‐truth times, where personal feelings and beliefs have become increasingly important, determining what is accurate knowledge has become an important skill. This is especially important during uncertainty crises (e.g., epidemics and pandemics) because alternative explanations other than scientific knowledge may be disseminated vigorously. Epistemic justification concerns how and in what way the truth of knowledge claims is justified and the criteria for knowledge to be true and/or a fact. Given this backdrop, the present study examined how individuals reacted to conspiracies in an uncertainty crisis (using the COVID‐19 pandemic as an example).AimThe mediating role of epistemic justification was investigated regarding its relationship between COVID‐19 conspiracy beliefs and COVID‐19 vaccine conspiracy beliefs.MethodsA cross‐sectional study was conducted incorporating a multifactorial correlational design. Using convenience sampling, 690 participants (55.7% females, Mage = 32.24 years, SD = 9.75) from different regions of Türkiye completed an online survey via Google Forms.ResultsThe results demonstrated a strong and statistically significant correlation between beliefs in COVID‐19 conspiracy theories and beliefs in COVID‐19 vaccination conspiracy theories. The mediating effects of justification by authority and personal justification were statistically significant between COVID‐19 conspiracy beliefs and COVID‐19 vaccine conspiracy theories.ConclusionUsing the COVID‐19 pandemic as an example, the present results indicated the complex relationships between conspiracy beliefs and epistemic justification. The present results indicate the importance of authorities in taking early action to provide scientific evidence and information to the public to avoid individuals believing false information.
Artificial intelligence‐enabled innovations in cochlear implant technology: Advancing auditory prosthetics for hearing restoration
Authors: Zhang Guodao , Chen Rui , Ghorbani Hamzeh , Li Wanqing , Minasyan Arsen , Huang Yideng , Lin Sen , Shao Minmin 
Published: January 2025

AbstractThis comprehensive review explores the implications of artificial intelligence (AI) in addressing cochlear implant (CI) issues and revolutionizing the landscape of auditory prosthetics. It begins with an overview of ear anatomy and hearing loss, then explores a review of CI technology and its current challenges. The review emphasizes how advanced AI algorithms and data‐driven approaches enhance CI adaptability and functionality, enabling personalized rehabilitation strategies and improving speech enhancement. It highlights diverse AI applications in auditory rehabilitation, including real‐time adaptive control mechanisms and cognitive hearing assistants that help users manage their auditory health. By outlining innovative pathways and future directions for AI‐enhanced CIs, the paper sets the stage for a transformative shift in auditory prosthetics, aiming to improve the quality of life for individuals with hearing loss.
Concomitant Usage of H1‐Antihistamines and Immune Checkpoint Inhibitors on Cancer Patient Survival
Authors: Leung Yin , Yip Terry Cheuk‐Fung , Wong Grace Lai‐Hung , Wong Vincent Wai‐Sun , Hui Vicki Wing‐Ki , Mok Tony Shu‐Kam , Chan Henry Lik‐Yuen , Chan Stephen Lam , Lui Rashid Nok‐Shun 
Published: January 2025

ABSTRACTPurposeRecent research (Li et al. 2021) suggests an upregulated expression and activation of H1 receptors on macrophages in the tumor microenvironment, and concomitant H1‐antihistamine use is associated with improved overall survival in patients with lung and skin cancers receiving immunotherapy. Therefore, we retrospectively evaluated the impacts of H1‐antihistamine use in cancer patients during immunotherapy.MethodsAll patients who had received at least one dose of immune checkpoint inhibitors (ICIs) from July 1, 2014 to October 31, 2019 were identified from Hong Kong's territory‐wide database, with this date defined as the baseline. A 1‐month landmark analysis was conducted with follow–for up to 6 months, including an exposure period of 1 month before and after the baseline date. Patients were grouped according to the types of primary cancer and the percentages of daily H1‐antihistamine usage within the exposure period. The primary outcome was overall survival.ResultsA total of 1740 (65.1% male, mean age 61.9 years) were included in the landmark analysis, of which 529 (30.4%) and 307 (17.6%) had primary lung and liver malignancies. The multivariable Cox regression model estimated statistically significant improvement in overall survival of intermediate use in patients with primary lung malignancies (adjusted hazard ratio [aHR] 0.223, 95% confidence interval [CI] 0.052–0.958, p = 0.044), but not with primary liver maligancies. Similar frequency‐dependent effects were identified in Kaplan–Meier analysis.ConclusionThe benefits of adjunctive use of H1‐antihistamines may be generation‐ and tumor‐dependent. Further clinical and mechanistic studies are required to confirm the findings.
Nano‐Formulated Pyraclostrobin With Iron Bismuthide Enhances Efficient Utilization of Active Ingredient and Improves Biosafety
Authors: Huang Fengcheng , Zhang Tianyu , Zhu Lisong , Wang Hongye , Zhao Yanjun , Wang Zejian , Huang Qingchun 
Published: January 2025

ABSTRACTThe widespread application of pyraclostrobin (PYR), an important strobilurin fungicide with low utilization efficiency, urgently requires optimization for sustainable agriculture. In this study, nanoformulated PYR with nano‐iron bismuthide (FeBi) was successfully prepared via flash nanoprecipitation, yielding spherical PYR/FeBi nanoparticles (NPs, Φ120 nm) with stable drug loading capacity (67.9%) and controlled release. These NPs exhibited enhanced anti‐Botrytis activity in vitro and superior in vivo performance. On tomato leaves, PYR/FeBi NPs at 80 µg/mL achieved greater than 90% curative and protective efficacy against Botrytis cinerea infection and significantly mitigated lesion expansion, surpassing commercial PYR suspension concentrate (SC) at equivalent concentrations. On tomato seedlings, PYR/FeBi NPs significantly reduced gray mold disease by 89%, compared to 67% with PYR SC at the same concentration. The mechanism underlying this enhanced activity involved stronger disruption of mitochondrial metabolism, including acetylation process, oxalate production, and damage to mycelia and conidia. Further, PYR/FeBi NPs displayed reduced cytotoxicity on human Hek293 and Chinese hamster V79 cells compared to PYR SC. The results highlighted the biocompatibility and potential of PYR/FeBi NPs for efficient utilization of active ingredients in sustainable agriculture.