bluuebunny/crossref_metadata_2025_split huggingface dataset:
THORACOLUMBAR SACRAL ORTHOSIS (TLSO) BRACE FOR SPINE FRACTURES: WHAT'S THE EVIDENCE AND DO PATIENTS USE THEM?
Authors: Mehta S. , Reddy R. , Nair D. , Mahajan U. , Madhusudhan T. , Vedamurthy A. 
Published: March 2023

IntroductionMode of non-operative management of thoracolumbar spine fracture continues to remain controversial with the most common modality hinging on bracing. TLSO is the device with a relative extension locked position, and many authors suggest they may have a role in the healing process, diminishing the load transferred via the anterior column, limiting segmental motion, and helping in pain control. However, several studies have shown prolonged use of brace may lead to skin breakdown, diminished pulmonary capacity, weakness of paraspinal musculature with no difference in pain and functional outcomes between patients treated with or without brace.AimsTo identify number of spinal braces used for spinal injury and cost implications (in a DGH), to identify the impact on length of stay, to ascertain patient compliance and quality of patient information provided for brace usage, reflect whether we need to change our practice on TLSO brace use.MethodsData collected over 18-month period (from Jan.2020 to July 2021). Patients were identified from the TLSO brace issue list of the orthotic department, imaging (X-rays, CT, MRI scans) reviewed to confirm fracture and records reviewed to confirm neurology and non-operative management. Patient feedback was obtained via post or telephone consultation. Inclusion criteria- patients with single or multi -level thoracolumbar osteoporotic or traumatic fractures with no neurological involvement treated in a TLSO brace. Exclusion criteria- neurological involvement, cervical spine injuries, decision to treat surgically, concomitant bony injuries.Results72 braces were issued in the time frame with 42 patients remaining in the study based on the inclusion/exclusion criteria. Patient feedback reflected that 62% patients did not receive adequate advice for brace usage, 73% came off the brace earlier than advised, and 60% would prefer to be treated without a brace if given a choice. The average increase in length of stay was 3 days awaiting brace fitting and delivery. The average total cost burden on the NHS was £127,500 (lower estimate) due to brace usage.ConclusionIf there is equivalence between treatment with/without a brace, there is a need to rethink the practice of prescribing brace for all non-operatively treated fractures and a case-by-case approach may prove more beneficial.
DYNAMIC HIP SCREW: ARE WE DOING IT ACCURATELY?
Authors: Rohra S. , Sinha A. , Kemp M. , Rethnam U. 
Published: March 2023

BackgroundDynamic Hip Screw (DHS) is the most frequently used implant in management of intertrochanteric femoral fractures. There is a known statistical relationship between a tip-apex distance (TAD) >25mm and higher rate of implant failure. Our aim was to analyse all DHS procedures performed in our trust from seventeen months and compare their TAD values to the acceptable standard of ≤25mm.MethodsAll patients undergoing DHS between April 2020-August 2021 were identified from our theatre system. Additionally, those presenting to hospital with implant failures were included. Patient demographics, date of surgery, fracture classification (AO) and date/mode of failure were recorded. Intraoperative fluoroscopy images were reviewed to calculate TAD, screw location and neck shaft angles by two independent observers.Results215 patients were identified, five of which were excluded due to inadequate fluoroscopy. Failure was seen in 3.3% of the cohort (n=7), of which 71.4% had an unacceptable TAD. In total, 21 patients (10%) had TAD >25mm, of whom 12 had superiorly and 15 had posteriorly placed screws. There were no failures in patients with a TAD of <20mm whereas a TAD >30mm had 50% failure rateConclusionThis audit reinforces the importance of aiming for a low TAD (preferably <20mm) intraoperatively. It is also desirable to avoid superiorly and significantly posteriorly placed screws.ImplicationsComplex hip revision surgery in the elderly bears substantial financial implications to the NHS and, more importantly, causes prolonged morbidity to the patient. Adhering to established standards will ensure reduced implant failure and best patient care.
Changes in the statistical properties of electromagnetic double multi-Gaussian Schell-model beams on propagation in free space
Authors: Sahin Serkan 
Published: March 2023

A class of electromagnetic random sources with a multi-Gaussian functional form in the spectral density and in the correlations part of the cross-spectral density matrix is introduced based on the genuine cross-spectral density-matrix theory. The analytic propagation formulas of the cross-spectral density matrix of such beams propagating in free space are derived by use of Collins’ diffraction integral. With the help of analytic formulas, the evolution of statistical characteristics, i.e., the spectral density, the spectral degree of polarization, and the spectral degree of coherence for such beams in free space are analyzed numerically. Employing the multi-Gaussian functional form in the cross-spectral density matrix introduces one more freedom in the modeling of Gaussian Schell-model sources.
High-performance, intelligent, on-chip speckle spectrometer using 2D silicon photonic disordered microring lattice
Authors: Lin Zhongjin , Yu Shangxuan , Chen Yuxuan , Cai Wangning , Lin Becky , Song Jingxiang , Mitchell Matthew , Hammood Mustafa , Jhoja Jaspreet , Jaeger Nicolas A. F. , Shi Wei , Chrostowski Lukas 
Published: March 2023

High-performance integrated spectrometers are highly desirable for applications ranging from mobile phones to space probes. Based on silicon photonic integrated circuit technology, we propose and demonstrate an on-chip speckle spectrometer consisting of a 15×15, 2D disordered microring lattice. The proposed 2D, disordered microring lattice was simulated by the transfer-matrix method. The fabricated device featured a spectral resolution better than 15 pm and an operating bandwidth larger than 40 nm. We also demonstrated that, based on the speckle patterns, our device can perform a spectrum classification using machine learning algorithms, which will have a huge potential in fast, intelligent material and chemical analysis.
Promoting GSDME expression through DNA demethylation to increase chemosensitivity of breast cancer MCF-7 / Taxol cells
Authors: Gong Weihua , Fang Panpan , Leng Maodong , Shi Ying 
Published: March 2023

Objective
Breast cancer is the most common and high-incidence cancer in women. It is mainly treated by surgery combined with chemoradiation. The main challenge in treating breast cancer patients is developing resistance to chemotherapeutics, so it is urgent to find potential strategies that can improve the chemotherapy effect of patients. In this study, we aimed to explore the role of GSDME methylation in the sensitivity of chemotherapy for breast cancer.

Methods
Here, we identified breast cancer MCF-7 / Taxol cells models using quantitative real-time PCR (qRT-PCR), Western blotting (WB), and cell counting kit-8 (CCK-8) analyses. Epigenetic changes in it were detected by Methylated DNA immunoprecipitation-sequencing and methylation-specific PCR. The expression level of GSDME in breast cancer cells was observed by qPCR and WB analyses. CCK-8 and colony formation assay were used to detect cell proliferation. Finally, pyroptosis was detected by LDH assay, flow cytometry, and WB analyses.

Results
Our results indicate that ABCB1 mRNA and p-GP expression are significantly increased in breast cancer MCF-7 / Taxol cells. GSDME enhancer methylation was found in drug-resistant cells and was associated with the down-regulation of GSDME expression. After treatment with decitabine (5-Aza-2’-deoxycytidine), the demethylation of GSDME induced the occurrence of pyroptosis and thereby inhibited the proliferation of MCF-7 / Taxol cells. We found that the upregulation of GSDME enhances the chemosensitivity of MCF-7 / Taxol cells to paclitaxel by inducing pyroptosis.

Conclusion
Taken together, we identified decitabine increases GSDME expression through DNA demethylation and induces pyroptosis, thus increasing the chemosensitivity of MCF-7 / Taxol cells to Taxol. Use of decitabine / GSDME / pyroptosis-based treatment strategies may be a new way to overcome the resistance of breast cancer to paclitaxel chemotherapy.
Ready for handwriting? A reference data study on handwriting readiness assessments
Authors: Haberfehlner Helga , de Vries Liesbeth , Cup Edith H. C. , de Groot Imelda J. M. , Nijhuis-van der Sanden Maria W. G. , van Hartingsveldt Margo J. 
Published: March 2023

Introduction
Early evaluation of writing readiness is essential to predict and prevent handwriting difficulties and its negative influences on school occupations. An occupation-based measurement for kindergarten children has been previously developed: Writing Readiness Inventory Tool In Context (WRITIC). In addition, to assess fine motor coordination two tests are frequently used in children with handwriting difficulties: the modified Timed Test of In-Hand Manipulation (Timed TIHM) and the Nine-Hole Peg Test (9-HPT). However, no Dutch reference data are available.

Aim
To provide reference data for (1) WRITIC, (2) Timed-TIHM and (3) 9-HPT for handwriting readiness assessment in kindergarten children.

Methods
Three hundred and seventy-four children from Dutch kindergartens in the age of 5 to 6.5 years (5.6±0.4 years, 190 boys/184 girls) participated in the study. Children were recruited at Dutch kindergartens. Full classes of the last year were tested, children were excluded if there was a medical diagnosis such as a visual, auditory, motor or intellectual impairment that hinder handwriting performance. Descriptive statistics and percentiles scores were calculated. The score of the WRITIC (possible score 0–48 points) and the performance time on the Timed-TIHM and 9-HPT are classified as percentile scores lower than the 15th percentile to distinguish low performance from adequate performance. The percentile scores can be used to identify children that are possibly at risk developing handwriting difficulties in first grade.

Results
WRITIC scores ranged from 23 to 48 (41±4.4), Timed-TIHM ranged from 17.9 to 64.5 seconds (31.4± 7.4 seconds) and 9-HPT ranged from 18.2 to 48.3 seconds (28.4± 5.4). A WRITIC score between 0–36, a performance time of more than 39.6 seconds on the Timed-TIHM and more than 33.8 seconds on the 9-HPT were classified as low performance.

Conclusion
The reference data of the WRITIC allow to assess which children are possibly at risk developing handwriting difficulties.
Practitioners’ perspectives on acupuncture treatment for postpartum depression: A qualitative study
Authors: Liu Fan , Zhan Tian-yu , Xu Yu-qin , Lu Xiao-fei , Zhou Yu-mei , Huang Xing-xian , Zhuo Yuan-yuan , Yang Zhuo-xin 
Published: March 2023

Background
Acupuncture may become a treatment for postpartum depression (PPD). Currently, little is known about the use of acupuncture in the treatment of PPD from the point of view of practitioners. The aim of this study was to explore practitioners’ perspectives on the treatment of PPD with acupuncture and provide suggestions for future improvement.

Methods
This study employed a qualitative descriptive method. Semistructured, open-ended interviews were conducted with 14 acupuncture practitioners from 7 hospitals via face-to-face or telephone interviews. The data were collected using interview outline from March to May 2022 and analysed using qualitative content analysis.

Results
In general, the use of acupuncture for treating PPD was positively regarded by practitioners. They claimed that acupuncture is both safe and helpful for breastfeeding women who are experiencing emotional discomfort and that it can alleviate a variety of somatic symptoms. The following three themes were extracted: (a) patient acceptance and compliance; (b) acupuncture as a treatment for PPD; and (c) the advantages and drawbacks of acupuncture treatment.

Conclusion
Practitioners’ optimistic outlooks demonstrated that acupuncture is a promising treatment option for PPD. However, the time cost was the most significant barrier to compliance. Future development will focus mostly on improving acupuncture equipment and the style of service.
Associations of age, sex, and socioeconomic status with adherence to guideline recommendations on protein intake and micronutrient supplementation in patients with sleeve gastrectomy or Roux-en-Y gastric bypass
Authors: Wiese Mats L. , Wilke Franziska , Gärtner Simone , Valentini Luzia , Keßler Wolfram , Aghdasssi Ali. A. , Lerch Markus M. , Steveling Antje 
Published: March 2023

Introduction
Patients with bariatric surgery often show poor long-term compliance to recommendations for prevention of nutrient deficiency but it is unclear which factors contribute. We investigated the associations of age, sex, and socioeconomic status (SES) with adherence to guideline recommendations on protein intake and micronutrient supplementation.

Methods
In a monocentric cross-sectional study we prospectively recruited patients with sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) and a minimum postoperative period of 6 months. Clinical and demographic data were obtained from the patients’ medical files and by questionnaire. Patients reported on supplement usage, recorded their dietary intake for seven days and underwent physical examinations including blood testing.

Results
We included 35 patients (SG: n = 25, RYGB: n = 10) with a mean (+SD) postoperative period of 20.2 (±10.4) months. Distributions of age, sex and SES were comparable between the SG and RYGB groups. Non-adherence to recommended protein intake was associated with age ≥ 50 years (p = 0.041) but not sex or SES. Protein intake inversely correlated with markers of obesity. There were no significant associations of age or sex with micronutrient supplementation. Only for vitamins A (p = 0.049) and B1 (p = 0.047) higher SES was associated with greater compliance. The only manifest deficiency associated with non-adherence to micronutrient supplementation was that for folic acid (p = 0.044).

Conclusion
In patients after bariatric surgery, those of older age and of lower SES might have a greater risk of unfavorable outcome and may require greater attention to micronutrient and protein supplementation.
Association between participation in the Northern Finland Birth Cohort 1966 study and use of psychiatric care services
Authors: Kerkelä Martta , Gissler Mika , Nordström Tanja , Veijola Juha 
Published: March 2023

Aims
In most population-based epidemiological follow-up studies the aim is not to intervene in the life of the participants. Although the idea is not to intervene, being a member of the longitudinal follow-up study and studies conducted during follow-up may affect the target population. A population-based study including mental health enquiries might reduce the unmet need for psychiatric treatment by motivating people to seek treatment for their psychiatric ill-health. We examined the use of psychiatric care services in the population born in the year 1966 in Northern Finland, of whom 96.3% are participants in the prospective Northern Finland Birth Cohort 1966 (NFBC1966).

Methods
As a study cohort we used people born in 1966 in Northern Finland (n = 11 447). The comparison cohort included all the people born in the years 1965 and 1967 in the same geographical area (n = 23 339). The follow-up period was from age 10 to 50 years. The outcome measure was the use of psychiatric care services, which was analysed using Cox Proportional Hazard regression and Zero-Truncated Negative Binomial Regression.

Results
People born in 1966 in Northern Finland did not differ from those born in 1965 and 1967 in terms of the outcome measure.

Conclusions
We found no association between participation in an epidemiological follow-up study and the use of psychiatric care services. The NFBC1966 may be regarded as a representative at the population level in terms of psychiatric outcomes despite the personal follow-up of the birth cohort. The associations of participation in epidemiological follow-up studies have previously been under-examined, and the results need to be replicated.
Nontrivial solution for Klein-Gordon equation coupled with Born-Infeld theory with critical growth
Authors: He Chuan-Min , Li Lin , Chen Shang-Jie 
Published: March 2023

Abstract
In this article, we study the following system:

−
Δ
u
+
V

(

x

)

u
−

(

2
ω
+
ϕ

)

ϕ
u
=
λ
f

(

u

)

+
∣
u

∣

4

u
,

in

R

3

,

Δ
ϕ
+
β

Δ

4

ϕ
=
4
π

(

ω
+
ϕ

)

u

2

,

in

R

3

,

\left\{\begin{array}{ll}-\Delta u+V\left(x)u-\left(2\omega +\phi )\phi u=\lambda f\left(u)+| u{| }^{4}u,& \hspace{0.1em}\text{in}\hspace{0.1em}\hspace{1em}{{\mathbb{R}}}^{3},\\ \Delta \phi +\beta {\Delta }_{4}\phi =4\pi \left(\omega +\phi ){u}^{2},& \hspace{0.1em}\text{in}\hspace{0.1em}\hspace{1em}{{\mathbb{R}}}^{3},\\ \end{array}\right.

where

f

(

u

)

f\left(u)

is without any growth and Ambrosetti-Rabinowitz condition. We use a cut-off function and Moser iteration to obtain the existence of nontrivial solution. Finally, as a by-product of our approaches, we obtain the same result for the Klein-Gordon-Maxwell system.
Activation of hypermethylated P2RY1 mitigates gastric cancer by promoting apoptosis and inhibiting proliferation
Authors: Hua Yinggang , Liu Yanling , Li Long , Liu Guoyan 
Published: March 2023

Abstract
The P2RY1 receptor is known to cause cancer by activating the ERK signal pathway, and its DNA methylation status and corresponding regulatory mechanism remain unknown. This study used the DNA methylation chip to profile the genome-wide DNA methylation level in gastric cancer tissues. The proliferation and apoptosis of the SGC7901 gastric cancer cell line were determined after treatment with a selective P2RY1 receptor agonist, MRS2365. The promoter region of P2RY1 was found to be highly methylated with four hypermethylated sites (|Δβ value| > 0.2) in diffuse gastric cancer and was validated by bioinformatics analysis in the TCGA database. Also, immunohistochemical staining data obtained from the HPA database demonstrated the downregulated expression of proteins encoded by P2RY1 in stomach cancer tissue. The analysis of MRS2365-treated cells by annexin V/propidium iodide staining and caspase-3 activity assays indicated the induction of apoptosis in SGC7901 cells. The P2RY1 receptor activation in human SGC7901 gastric cancer cells via the MRS2365 agonist induced apoptosis and reduced cell growth. High DNA methylation in the promoter region of P2RY1 might have contributed to the reduced expression of P2RY1’s mRNA, which was likely responsible for the “aggressive” nature of the diffuse gastric cancer.
Association between the VEGFR-2 -604T/C polymorphism (rs2071559) and type 2 diabetic retinopathy
Authors: Yuan Yazhen , Shao Chenjun , Guan Yongqing , Lu Hongwei , Wang Dandan , Zhang Shuangmei 
Published: March 2023

Abstract
This retrospective case–control study examined the association between the rs2071559 (-604T/C) single nucleotide polymorphism (SNP) in the vascular endothelial growth factor receptor (VEGFR)-2 gene and the risk of diabetic retinopathy (DR) in Northern Han Chinese. This study included patients diagnosed with diabetes mellitus (DM) in Shijiazhuang between 07/2014 and 07/2016. The healthy controls were unrelated individuals who received routine physical examinations. The diabetic patients were grouped as DM (diabetes but no fundus examination abnormalities), proliferative DR (PDR), and non-proliferative DR (NPDR). Finally, 438 patients were included: 114 controls and 123, 105, and 96 patients in the DM, NPDR, and PDR groups, respectively. In the multivariable analyses and all genetic models, the VEGFR-2 rs2071559 SNP was not associated with DR (among all diabetic patients) or with PDR (among the patients with DR) after adjustment for age, sex, duration of DM, blood glucose, systolic blood pressure, diastolic blood pressure, and body mass index (all P > 0.05). In conclusion, the VEGFR-2- 604T/C rs2071559 SNP is not associated with DR or PDR in the Han Chinese population of Shijiazhuang (China).
Triple-negative mouse breast cancer initiating cells show high expression of beta1 integrin and increased malignant features
Authors: Fu Jing , Peng Shengkun 
Published: March 2023

Abstract
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that exhibits aggressive tumor phenotypes, including rapid metastasis and tumor recurrence. Integrins belong to the family of transmembrane glycoproteins involved in regulating cell adhesion, proliferation, and differentiation through cell–cell and cell–extracellular matrix interactions. Aberrant β1 integrin signaling has been implicated in cancer invasion and metastasis processes. The present work aimed to investigate the role of β1 integrin in TNBC cancer progression using a mouse 4T1 cell line as a model system. We have sorted a subset of tumor-initiating cells (TICs) from the 4T1 cell line based on CD133 positivity by flow cytometry. RT-PCR and protein analysis studies showed the transcriptional upregulation of β1 integrin and its downstream target focal adhesion kinase in 4T1-TICs compared to parental 4T1 cells. In addition, the expression of β1 receptors in TICs is significantly higher than in parental population cells. Furthermore, in vitro cellular assays revealed that CD133+ TICs have higher clonogenic ability, invasion, and sphere formation potential. These findings suggest that β1 integrin has a potential role in TNBC invasion and metastasis. Hence, β1 integrin could be a possible factor for future targeted cancer therapies.
An imagery-based intervention for managing anxiety in esports
Authors: Munroe-Chandler Krista J. , Loughead Todd M. , Zuluev Erkin G. , Ely Frank O. 
Published: March 2023

Abstract
The popularity and commercial success of videogames in the current era has given rise to a new type of competition: electronic sports (or esports). Researchers have proposed that esports players would benefit greatly from the applied sport psychology work typically conducted with traditional athletes and more specifically from evidence-based interventions. Imagery interventions have proven beneficial for the traditional athlete at managing anxiety in competitive settings, and in fact League of Legends players have noted the importance of mental skills, including imagery, to achieving optimal performance. The aim of the current paper is to provide practitioners with an imagery intervention specifically designed for managing anxiety in League of Legends players. Three 30-min workshops are described wherein the practitioner follows the three phases of Psychological Skills Training; education, acquisition and practice.
Field enhancement of epsilon-near-zero modes in realistic ultrathin absorbing films
Authors: Anopchenko Aleksei , Gurung Sudip , Bej Subhajit , Lee Ho Wai Howard 
Published: March 2023

Abstract
Using electrodynamical description of the average power absorbed by a conducting film, we present an expression for the electric-field intensity enhancement (FIE) due to epsilon-near-zero (ENZ) polariton modes. We show that FIE reaches a limit in ultrathin ENZ films inverse of second power of ENZ losses. This is illustrated in an exemplary series of aluminum-doped zinc oxide nanolayers grown by atomic layer deposition. Only in a case of unrealistic lossless ENZ films, FIE follows the inverse second power of film thickness predicted by S. Campione, et al. [Phys. Rev. B, vol. 91, no. 12, art. 121408, 2015]. We also predict that FIE could reach values of 100,000 in ultrathin polar semiconductor films. This work is important for establishing the limits of plasmonic field enhancement and the development of near zero refractive index photonics, nonlinear optics, thermal, and quantum optics in the ENZ regime.