bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-Course physiopathology of Porthidium lansbergii lansbergii Envenomation in Swiss Webster Mice: Insights into Systemic Manifestations
Authors: Montealegre-Sánchez Leonel , Lima Mikael A. , Montoya-Gómez Alejandro , Solano-Redondo Luis , Silva Dayara O. , Alves Pereira Karuza M. , Lima Mota Mario R. , Silveira Edilberto Rocha , de Sousa Brasil Nilce Viana Gramosa Pompeu , Alves Filho Elenilson G. , Havt Alexandre , Jiménez-Charris Eliécer 
Published: January 2025

Objective The expansion of human activities in northern Colombia has increased human-snake encounters, particularly with venomous Porthidium lansbergii lansbergii. Given the limited knowledge of systemic envenomation effects and previous studies focusing only on early murine symptoms, this investigation aimed to describe the time-course physiopathology of P. lansbergii lansbergii envenomation following intramuscular injection in vivo. Methods Venom was inoculated in the gastrocnemius muscles of Swiss Webster mice, and blood, urine, and tissue samples were taken at different times to evaluate lethality and biochemical markers of renal function and oxidative stress. Results This study reports the first intramuscular LD50 for P. lansbergii lansbergii venom at 24.83 mg/Kg. Administering 80% of this LD50 induced early signs of renal injury, evidenced by urinary biomarkers over 24 h. The antioxidant activity was found at low levels in kidney tissue throughout the evaluated time post-envenomation. Malondialdehyde activity increased at the earliest point, while proinflammatory activity increased later. Urine metabolomics revealed elevated taurine and allantoin in the envenomed groups. Discussion Compensatory mechanisms in response to oxidative stress and tissue damage induced by the venom were evident in the envenomed mice over the evaluated time. However, histological analysis revealed evidence of pro-inflammatory processes occurring only at early times. Metabolomic analyses of urine samples identified taurine as a potential early biomarker of elevated oxidative stress and protein and creatinine levels. Conclusions P. lansbergii lansbergii venom induces alterations in murine renal tissue, affecting urinary biomarkers of kidney function within hours post-envenomation. Delayed proinflammatory effects may suggest an antioxidant imbalance in the envenomed mice, with unknown long-term effects. Further research on the role of oxidative stress and inflammation in renal structure and function following envenomation is necessary, emphasizing the need for prompt clinical management.
Cardiac return assist blanket (CRAB) safely increases central venous pressure
Authors: Mitchell Christopher , Jacques Angela 
Published: January 2025

Objective The cardiac return assist blanket (CRAB) has been designed to increase central venous pressure (CVP) to manage severe hypotension associated with anaphylaxis. This interventional study aimed to identify the relationship between CRAB pressure and CVP. CRAB pressure was also compared with the change in CVP associated with a straight leg raise (SLR), the Trendelenburg position, and 1 L of compound sodium lactate. Methods Sixteen healthy, fasted volunteers were exposed to CRAB pressure at 10, 20, 30, and 40 cmH2O, the SLR, and 15 degrees of the Trendelenburg position. The volunteers were then fed and hydrated with 1 L of CSL over 30 minutes and the protocol was repeated. Results The initial 10 cmH2O of CRAB pressure increased CVP by 3.7 mmHg (95% confidence interval 2.7, 4.7). Each subsequent 10-cmH2O rise in CRAB pressure increased CVP by 0.9 mmHg (95% confidence interval 0.55, 1.25). The SLR, Trendelenburg position, and 1 L of CSL increased CVP by 0.97 , 0.75 , and 0.69 mmHg, respectively. Conclusions The CRAB controllably increases CVP, and 40 cmH2O of CRAB pressure increases CVP by 6.41 mmHg. The effect of the CRAB is greater than that with the SLR, Trendelenburg position, or 1 L of CSL. This trial was registered with the ANZCTR (ACTRN12621000840886: https://www.anzctr.org.au ).
A Time-Series Analysis of News Media Coverage of Suicide in Canada from 2019 to 2023: Une analyse de séries chronologiques de la couverture responsable du suicide par les médias au Canada de 2019 à 2023
Authors: Careau Juliette , Bélair Justin , Whitley Rob 
Published: January 2025

Objective Evidence suggests that the media can play a role in preventing suicide, as well as contributing to suicide contagion. As such, the primary objective is to assess adherence to responsible reporting of suicide recommendations in news articles about suicide over time. A secondary objective is to assess whether reporting changed significantly during the COVID-19 pandemic. The tertiary objective is to assess overall patterns regarding types of suicide reported. Methods We collected news articles with the keyword “suicide” from 47 Canadian news sources between April 1, 2019, and March 31, 2023. Articles were coded for adherence to key responsible reporting of suicide guidelines. Frequency counts and percentages of adherence were calculated for all key variables. Time series analyses using a Generalized Linear Autoregressive Moving Average model assessed for adherence trends over time, including measuring for any changes during the COVID-19 years. Results Study procedures resulted in 3,232 coded news articles. Overall, the results indicate that adherence to the guidelines has moderately improved over the course of the 4-year period. This is especially true for recommendations regarding avoiding putatively harmful content, such as detailed descriptions of the suicide method. Similar improvements were seen in adherence to guidelines related to the inclusion of putatively helpful content, with significantly more articles providing help-seeking information. However, in the final year of the study, less than a third of articles included educational content about suicide, help-seeking information, or quotes from suicide experts. Reporting of suicide during the COVID-19 period showed some positive improvements; however, these were not sustained after the pandemic ended. Conclusions On the plus side, adherence to responsible suicide reporting guidelines improved over the 4-year period, especially for recommendations concerning putatively helpful content. However, there remains room for improvement regarding the inclusion of putatively protective content such as including help-seeking information, educating about suicide, and quoting experts.
Commentary on the Canadian Network for Mood and Anxiety Treatments 2024 Clinical Practice Guideline for the Management of Perinatal Mood, Anxiety and Related Disorders: Evidence-Based Treatments Require Appropriate Systems of Care to Be Implemented
Authors: Boyce Philip 
Published: January 2025

Plain Language Summary This is a commentary of the CANMAT guideline Key points about the CANMAT perinatal guidelines are commented on. The process of developing the guidelines was robust and there can be a high level of confidence in their recommendations. An important aspect is that services for women with perinatal mood and anxiety disorders need to put in place so that the range on evidence based treatments can be implemented.
Investigation of polyvinylpyrrolidone-catechol-derived chitosan nanoconjugates allowed for kidney-targeted treatment of cisplatin-induced acute kidney injury and nursing care management
Authors: Chen Guixian 
Published: January 2025

Acute kidney injury (AKI) resulting from cisplatin (Cs) chemotherapy presents a significant challenge in clinical management. The study aimed to fabricate a novel compound Polyvinylpyrrolidone-catechol-derived chitosan nanoconjugates (PCChi-NC) for targeting Cs-induced AKI. Characterization studies utilizing UV-visible spectrophotometry, FT-IR, XRD, and TEM revealed a spherical morphology with diameters ranging from 20 to 60 nm. In vitro assessments utilizing HEK 293 cell lines demonstrated the biocompatibility of PCChi-NC without eliciting toxic effects. Furthermore, PCChi-NC exhibited a notable reduction in Cs-induced cell death in kidney cells, as evidenced by biomarker analysis. Anti-inflammatory analysis of mouse kidney homogenates revealed a decrease in TNF-α and IL-1β levels, indicative of the therapeutic efficacy of PCChi-NC in mitigating Cs-induced kidney inflammation. Moreover, In vivo, experimental analysis was evidenced by stable body weight and histopathological changes in mice. Our findings highlight the potential of PCChi-NC as a promising candidate for targeted therapy in Cs-induced AKI, owing to its unique renal targeting capacity.
Impact of a Multi-Component Home-Based Physical Therapy Intervention on Cognitive Outcomes: Results From the CAP Randomized Controlled Trial
Authors: Gruber-Baldini Ann L. , Fortinsky Richard H. , Resnick Barbara , Magder Laurence S. , Beamer Brock A. , Mangione Kathleen , Orwig Denise , Binder Ellen F. , Terrin Michael , Magaziner Jay 
Published: January 2025

Objective Differences in cognitive outcomes for two home-based 16-week interventions after usual rehabilitative care post-hip fracture were examined. Methods Community Ambulation Project randomized controlled trial included 210 hip fracture participants. Interventions: Specific multi-component (PUSH) included strength-, balance-, function-, and endurance-based exercises; non-specific active control (PULSE) included seated range-of-motion exercises and sensory transcutaneous electrical neurostimulation. Cognitive measures: Modified Mini-Mental State Examination, plus Hooper Visual Organization Test and Trails A/B in an ancillary study (CAP-MP, n = 40), assessed pre-randomization and 16 and 40 weeks post-randomization. Results Over 16 weeks, PUSH-assigned participants became faster on Trails A (Δ = −6.3, 95% CI: −16.7, 4.2); those in PULSE became slower (Δ = 9.3, 95% CI: −1.7, 20.3, p = .04). At 40 weeks, PUSH-assigned participants became faster on Trails B (Δ = −21.5, 95% CI: −46.2, 3.3) while those in PULSE became slower (Δ = 15.2, 95% CI: −11.9, 42.3, p = .04). No other significant differences were found. Discussion Results suggest that multi-component exercise interventions like PUSH may prevent/delay decline or improve attention and psychomotor speed in patients with recent hip fracture.
Implementation and Evaluation of a High-Fidelity, Interprofessional Simulation Project Using Standardized Patients to Address Aggression in a Psychiatric Emergency Department
Authors: Bowllan Nancy M. , O’Brien Heather P. , Blackwood Courtney , Cross Wendi F. , Walsh Patrick 
Published: January 2025

Introduction Increased aggression in a regional Comprehensive Psychiatric Emergency Program (CPEP) led to a significant rise in physical assaults, restraints, and use of security personnel. Root cause analysis revealed a need for more extensive training on de-escalation, teamwork and communication. Aims: This quality improvement project evaluated the impact of an interprofessional, high-fidelity simulation project on interdisciplinary collaboration to manage de-escalation and aggression safely and effectively. Methods: Interdisciplinary team members ( N = 171 nurses, psychiatrists, social workers, crisis specialists, and safety officers) participated in a 2.5-hr educational initiative that included Crisis Prevention Intervention (CPI) and Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS) interventions, high-fidelity simulation using standardized patients, observation, and debriefing. Quantitative data collection and analysis included the use of the Confidence in Coping with Patient Aggression Instrument (CCPAI), TeamSTEPPS Perception Questionnaire (T-TPQ), pre–post data on restraints, injuries, and an educational survey. A qualitative analysis of debriefing themes was also performed. Results: Statistically significant improvement was noted in individuals’ confidence to manage aggression. In addition, data collected over a 5-month period before and after simulation demonstrated a 35% reduction in restraints and a 52% reduction in injuries. Interestingly, quantitative evidence revealed no changes in perceptions of teamwork. Results from the educational survey highlighted the positive impact of standardized patients and debriefing, and gaining new insights into patient care. Qualitative analysis of debriefing themes revealed educational opportunities to improve communication, role clarity, de-escalation, and insights into patient impact. Conclusion: The use of high-fidelity simulation with standardized patients has the potential to strengthen interdisciplinary collaboration to safely manage aggression in an acute psychiatric setting.
Effect of acetate- and lactate-containing intravenous fluid on acid-base status, electrolytes and plasma lactate concentration in dehydrated cats
Authors: Banzhaf Isabel , Klein-Richers Ute , Heitland Annika , Hartmann Katrin , Dörfelt René 
Published: January 2025

Objectives Acetate (ACE) and lactate (LAC)-containing balanced resuscitation fluids are commonly used for fluid therapy in cats. These fluids can influence acid-base and electrolyte status. This prospective randomised study compared two balanced crystalloid solutions regarding their effect on acid-base status, electrolytes and LAC concentrations in dehydrated cats after intravenous fluid therapy. Methods A total of 100 client-owned cats presenting to the emergency service with dehydration ⩾5% due to diarrhoea, vomiting or anorexia were included in this study. They were randomised to receive either ACE- (Sterofundin ISO; B Braun Vet Care) or LAC-containing (Ringer-Laktat nach Hartmann; B. Braun Vet Care) fluids for rehydration. Exclusion criteria were age <6 months, severe electrolyte abnormalities, severely increased creatinine or bolus therapy, and decompensated heart disease and liver diseases. Vital parameters were assessed and venous blood gas analysis was performed before and after fluid therapy. Data were analysed using the Mann–Whitney U-test and the Wilcoxon matched-pairs signed-rank test. The significance level was set at P ⩽0.05. Results Post-rehydration pH normalised, and bicarbonate and base excess increased in both groups. Anion gap and LAC and potassium concentrations decreased in both groups. No difference in electrolyte, acid-base status and LAC was observed between cats receiving ACE and cats receiving LAC. Conclusions and relevance Both fluids have similar effects on dehydrated cats’ acid-base status and electrolyte and LAC concentrations. No significant differences in values were found between ACE- and LAC-containing resuscitation fluids. Blood LAC concentration decreased in both groups.
Diagnostic and Predictive Recurrence Value of Plasma Fibrinogen in Patients With Adrenocortical Carcinoma
Authors: Ma Chengquan , Yang Bin , Mao Quanzong 
Published: January 2025

Background: The correlation between fibrinogen levels and adrenocortical carcinoma (ACC) remains unclear. This study aimed to explore the value of preoperative plasma fibrinogen as a biomarker for ACC. Methods: We identified 40 patients with ACC and 170 patients with adrenal adenoma (AA) who underwent surgery at our institution between 2015 and 2022. Plasma fibrinogen levels and postoperative tumor recurrence information of the patients were also recorded. For intergroup comparisons, data obtained from the AA and ACC groups were evaluated using a t-test. The cutoff value of fibrinogen level was determined using a receiver operating characteristic (ROC) curve. Results: Mean fibrinogen levels in the AA and ACC groups were 2.81 ± 0.59 g/L and 3.88 ± 1.75 g/L, respectively ( P < .001). Fibrinogen level, which can help distinguish between AA and ACC, was evaluated using the ROC curve. The cutoff fibrinogen level was estimated as 3.87 g/L according to the Youden index. With this value, the sensitivity was 62.5%, specificity was 95.7%, and the area under the ROC curve (AUC) was 0.74 ( P < .001). Fibrinogen level, which can help distinguish between recurrence and non-recurrence, was evaluated using the ROC curve. The cutoff fibrinogen level was estimated as 3.96 g/L according to the Youden index. The sensitivity, specificity, and AUC were 90%, 71.4%, and 0.85, respectively ( P < .001). Conclusion: According to the data in this study, plasma fibrinogen could be used to distinguish ACC from AA. Most importantly, plasma fibrinogen may be used to identify recurrence of postoperative ACC.
Development of silver nanoparticles infiltrated PLA films for food packaging
Authors: Kawale Ashlesha , Shukla Sourabh , Thiruvengadam Veeraswamy , Bansod Ankur 
Published: January 2025

Biodegradable polymers are substitutes for non-biodegradable polymers manufactured from fossil fuels to reduce plastic waste. Polylactic acid is a promising candidate for biodegradable polymers. Antimicrobial agents such as silver and copper are added to polylactic acid to improve its antimicrobial properties for food packaging applications. In this work, silver nanoparticles were infiltrated into the polylactic acid matrix to form composite films. The presence of silver nanoparticles has enhanced antimicrobial resistance with attested its suitability to be explored like food packaging film. Additionally, the nanoparticle composite film was to be non-toxic and to have high durability. The properties of polylactic acid/silver nanoparticle films were studied as a function of the silver nanoparticle's weight percentage (0%, 5% and 10%). The incorporation of silver nanoparticles in the polylactic acid matrix was established by Fourier transform infrared spectroscopy spectrometer, ultraviolet-visible spectrometer, and field emission-scanning electron microscopy. Fourier transform infrared spectroscopy and ultraviolet-visible spectrum suggest the presence of silver nanoparticles in the composite films. Thermal gravimetric analysis and differential calorimeter analysis reveal the change in degradation and glass transition temperature with an increase in silver nanoparticle concentration. The antibacterial property using the disk diffusion method indicates that polylactic acid/silver nanoparticles (10%) had the highest antibacterial property. Antibacterial action is enhanced when silver nanoparticles are combined with a tiny dose of antibiotics, especially when battling multi-strain-resistant bacteria. Graphical Abstract [Formula: see text]
Perianastomotic pH Monitoring for Early Detection of Anastomotic Leaks in Gastrointestinal Surgery: A Systematic Review of the Literature
Authors: Walshaw Josephine , Hugh Katherine , Helliwell Jack , Burke Joshua , Jayne David 
Published: January 2025

Introduction Anastomotic leak (AL) represents a significant complication following gastrointestinal (GI) surgery, contributing to increased morbidity and mortality. pH monitoring has emerged as a potential diagnostic tool for the early detection of AL, but its effectiveness and clinical utility remain to be fully elucidated. This review aims to summarise the evidence regarding perianastomotic pH monitoring for AL detection. Methods A systematic search of relevant databases was conducted to identify pre-clinical and clinical studies investigating pH monitoring for AL detection following GI surgery. Studies were screened by two independent reviewers based on predefined inclusion and exclusion criteria. Data were extracted and presented as a narrative synthesis. Results A total of 10 studies were included in the review, comprising animal studies (n = 2), and human studies in upper GI (n = 3) and colorectal (n = 5) patients. Consistent findings of lower pH values in patients with AL across various postoperative time points were demonstrated. There was diversity in the pH detection method, in addition to variable frequency and timing of pH monitoring. Four studies reported a shorter time for AL detection with pH monitoring vs conventional methods, although no statistical comparisons were used. No standard pH cut-off value for AL detection was identified. Conclusion pH monitoring shows potential as a diagnostic tool for the early detection of AL following GI surgery. While the existing evidence supports its potential utility, further research is required to establish standardised protocols and assess its clinical impact.
Unusual anatomic variation: The posterior inferior cerebellar artery arising from the middle meningeal artery
Authors: Lozupone Emilio , Scalise Simona , Trombatore Pietro , Pauciulo Alfredo , Direnzo Vita , Signorelli Francesco , Barbarini Leonardo , Paladini Adriana 
Published: January 2025

An adult patient was admitted to our emergency department for a first episode of generalized tonic-clonic seizure. Computed tomography scan and magnetic resonance imaging showed a temporal intracranial hemorrhage and parenchymal edema caused by a dural arteriovenous fistula (DAVF), whose angioarchitecture was better understood through the DSA which showed as intriguing and rare vascular anomaly the origin of the posterior inferior cerebellar artery (PICA) from the middle meningeal artery (MMA). The endovascular treatment of the DAVF was then successfully performed. This case describes the first case of a PICA arising from the MMA in the literature and highlights as an accurate knowledge of vascular anatomy and its variations is essential for the endovascular treatment of the cerebrovascular diseases.
Self-compassion in chronic pain: Validating the self-compassion scale short-form and exploring initial relationships with pain outcomes
Authors: Gillett Jenna L , Rakhimov Arman , Karadag Paige , Themelis Kristy , Ji Chen , Tang Nicole KY 
Published: January 2025

Objectives Validate the English version of the Self-C ompassion Scale S hort-F orm (SCS-SF) as a reliable measure in chronic pain. Explore self-compassion’s relationship with pain-related outcomes. Methods A total of 240 chronic pain patients (at 6-months) and 256 community participants (at 12-months) completed two prospective survey studies. SCS-SF psychometric properties were evaluated through exploratory and confirmatory factor analyses (EFA and CFA), exploratory structural equation modelling (ESEM), test–retest reliability (Pearson’s r) and internal consistency (Cronbach’s α) in both samples. Convergent validity/clinical relevance was assessed in the chronic pain sample via univariate linear regressions between self-compassion and pain intensity, interference, catastrophizing, self-efficacy, anxiety and depression. Results The SCS-SF showed acceptable internal consistency in both samples (α > 0.70, range = 0.74–0.79), high test–retest reliability over 6-months in the pain sample (r = 0.81, p < .001) and sub-threshold over 12-months in the community (r = 0.59 p < .001). EFA revealed a two-factor model distinguishing compassionate and uncompassionate self-responding in both samples. CFA identified a one-factor and two-factor model in both samples, but it did not meet statistical thresholds. ESEM identified the best fit for the chronic pain group was for a two-factor model (RMSEA and SRMR < 0.08; CFI and TLI > 0.90), whereas no models met acceptable fit criteria in the community group. A two-bifactor Bayesian model had suitable fit in both groups. In the chronic pain sample, SCS-SF and compassionate self-responding negatively predicted pain intensity, interference, anxiety, depression, catastrophizing and positively predicted self-efficacy over 6-months. Uncompassionate self-responding positively predicted anxiety, depression, catastrophizing and negatively predicted self-efficacy but did not predict pain outcomes. Discussion The SCS-SF is a reliable and valid measure in chronic pain. Total and sub-factor scores appear to have distinct relationships with pain outcomes. Future research should consider self-compassion as a unitary and/or bifactorial (consisting of compassionate and uncompassionate self-responding) construct in chronic pain when measured using the SCS-SF.