bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quasi-periodic eruptions as Lense–Thirring precession of super-Eddington flows
Authors: Middleton M , Gúrpide A , Kwan T M , Dai L , Arcodia R , Chakraborty J , Dauser T , Fragile P C , Ingram A , Miniutti G , Pinto C , Kosec P 
Published: January 2025

ABSTRACT
Quasi-periodic eruptions (QPEs) are a recently identified class of X-ray transient associated with tidal disruption events by supermassive black holes, and for which there are multiple possible explanations. In this paper, we present a simple model which requires the black hole be spinning, be misaligned with the accretion flow (both conditions of which are almost certainly met), and that the accretion rate is a few times the Eddington limit. We speculate that the resulting Lense–Thirring torques force the disc and entrained outflows to precess, leading to increased X-ray flux when the wind-cone is oriented at lower inclinations to the observer. We test the range of parameters for which this model could explain the period and brightness of the QPE events discovered thus far, and make qualitative comparisons between the observed X-ray spectra and light curves to those extracted from general relativistic radiation magnetohydrodynamic simulations. Overall, we find some areas of promising concordance, and identify challenges related to the details of current simulations.
The Presumption of Duties to Oneself
Authors: Kanygina Yuliya 
Published: January 2025

Abstract
Morality is fundamentally impartial. No one can be simply excluded from moral consideration without justification in terms of a morally relevant distinction. I claim that moral impartiality justifies establishing the presumption in favor of duties to oneself. I vindicate this claim against the challenge that there must be a morally relevant self-other distinction which explains the commonsense moral asymmetry. I show that the asymmetry can be explained instead by the presupposition of consent. I end by responding to the objection that the consent-based explanation of the asymmetry condemns potential duties to oneself as practically uninteresting.
Duties to Oneself in the Light of African Values: Two Theoretical Approaches
Authors: Metz Thaddeus 
Published: January 2025

Abstract
I draw on ideas salient in African philosophy to construct two new theoretical ways of capturing the essence of duties to oneself. According to one theory, a person has a basic duty to “relate” to herself in ways similar to how the African field has often thought one should relate to others, viz., harmoniously, while, according to a second, one has such a duty to produce liveliness in oneself. Beyond articulating these two novel attempts to account for what all duties to oneself have in common and showing that each captures several intuitions about them, I offer reasons to favor the harmony theory, meriting consideration by a global audience as a rival to, say, the Kantian-rationalism common in the West and Confucianism in the East.
Duties to the Unified Self
Authors: Leuenberger Muriel 
Published: January 2025

Abstract
Duties to self are commonly considered as incoherent. If I owed a duty to myself, I could release myself from it at will which would be incoherent with it being a duty. Recent years have seen various attempts at defending duties to self against this argument. A common strategy entails that the self is divided. One part of the self owes a duty to another. I argue that understanding duties to self as being owed to a part of the self leads to problems because a person has interests that go beyond those of the single parts. Instead, I suggest that duties to self are owed by a local self (or rather, a local perspective) to an extended or unified self.
Integrity and Morality
Authors: Schaab Janis David 
Published: January 2025

Abstract
This paper defends a strong link between personal integrity and morality in a way that preserves the overriding and universal authority of impartial morality. I argue that, when we are committed to a personal project or relationship, we hold ourselves accountable, from the perspective of a corresponding practical identity, for living up to the commitment. Under the right conditions, this generates an obligation to ourselves. Supposing that holding someone accountable constitutively presupposes a version of Kant’s Formula of Humanity (as Stephen Darwall argues), such obligations of integrity turn out to be moral obligations. Although the picture presented here resembles Christine Korsgaard’s account of the link between integrity of morality, it has several advantages over that account.
The Normative Power of Resolutions
Authors: Sun Angela 
Published: January 2025

Abstract
This article argues that resolutions are reason-giving: when an agent resolves to φ, she incurs an additional normative reason to φ. I argue that the reasons we incur from making resolutions are importantly similar to the reasons we incur from making promises. My account explains why it can be rational for an agent to act on a past resolution even if temptation causes preference and even judgment shifts at the time of action, and offers a response to a common objection to the normativity of resolutions known as the bootstrapping problem, on which if resolutions were reason-giving they would problematically allow us to bootstrap any action into rationality simply by resolving to perform it.
Scepticism About Self-Knowledge of Motives
Authors: Hubacher Haerle Pablo 
Published: January 2025

Abstract
Many philosophers claim that we have a duty to know our motives. However, prominent theories of the mind suggest that we can’t. Such scepticism about knowledge of one’s motives is based on psychological evidence. I show that this evidence only mandates scepticism about knowledge of one’s motives if we rely on a mistaken assumption which I call ‘the myth of the one true motive’. If we reject this myth, we see that there is space to plausibly interpret the empirical data such that knowledge of one’s motives is difficult, but not impossible.
GDBr: genomic signature interpretation tool for DNA double-strand break repair mechanisms
Authors: Ryu Hyunwoo , Han Hyunho , Kim Chuna , Kim Jun 
Published: January 2025

Abstract
Large genetic variants can be generated via homologous recombination (HR), such as polymerase theta-mediated end joining (TMEJ) or single-strand annealing (SSA). Given that these HR-based mechanisms leave specific genomic signatures, we developed GDBr, a genomic signature interpretation tool for DNA double-strand break repair mechanisms using high-quality genome assemblies. We applied GDBr to a draft human pangenome reference. We found that 78.1% of non-repetitive insertions and deletions and 11.0% of non-repetitive complex substitutions contained specific signatures. Of these, we interpreted that 98.7% and 1.3% of the insertions and deletions were generated via TMEJ and SSA, respectively, and all complex substitutions via TMEJ. Since population-level pangenome datasets are being dramatically accumulated, GDBr can provide mechanistic insights into how variants are formed. GDBr is available on GitHub at https://github.com/Chemical118/GDBr.
Extensive homologous recombination safeguards oocyte genome integrity in mammals
Authors: Cao Huiwen , Qiu Cheng , Fang Anxuan , Shang Jianzhou , Xu Wei , He Lugeng , Duan Xing , Zhang Qianting , Yu Chao 
Published: January 2025

Abstract
Meiosis in mammalian oocytes is interrupted by a prolonged arrest at the germinal vesicle stage, during which oocytes have to repair DNA lesions to ensure genome integrity or otherwise undergo apoptosis. The FIRRM/FLIP-FIGNL1 complex dissociates RAD51 from the joint DNA molecules in both homologous recombination (HR) and DNA replication. However, as a type of non-meiotic, non-replicative cells, whether this RAD51-dismantling mechanism regulates genome integrity in oocytes remains elusive. Here, we show that FIRRM/FLIP is required for disassembly of RAD51-filaments and maintenance of genome integrity in oocytes. Deletion of FIRRM in oocytes leads to formation of massive nuclear RAD51 foci in oocytes of primordial follicles and activated follicles in mice. These RAD51 foci colocalize with the sites of DNA damage repair, as indicated by RPA2 and EdU, suggesting substantial DNA damage and extensive HR in oocytes. Especially in fully-grown FIRRM-deleted oocytes, RAD51 forms a net-like structure. As a consequence, FIRRM-deleted females are infertile due to aberrant homologous chromosome segregation at metaphase I and primordial follicle insufficiency at young adulthood. Hence, our study demonstrates the physiological importance of HR in maintaining genome integrity in oocytes.
Modeling Falco naumanni (Lesser Kestrel) habitat selection according to meteorological conditions to identify risk-inducing wind turbines
Authors: Sassi Yohan , Bartholus Lise , Garcia Mathieu , Saulnier Nicolas , Pilard Philippe , Duriez Olivier 
Published: January 2025

Abstract
Wind energy can produce energy while limiting carbon emissions, but it has many negative impacts on biodiversity. Raptors, relying on updrafts to soar and reduce their energy expenditure, are among the most vulnerable to collisions with wind turbines. In this study, we investigated the factors underlying the use of a wind energy facility in Southern France by Falco naumanni (Lesser kestrels), where they are the most frequent victims of collisions. As F. naumanni relies on wind updrafts to practice hovering flight when looking for prey, we hypothesized that these birds would be distributed according to the distribution of orographic updrafts. Using telemetry tracking data collected on 26 adults F. naumanni, between 2017 and 2021, we found that their presence in the wind energy facility increased with orographic updrafts velocity but decreased as the breeding season progressed. Using resource selection models, we predicted the relative probability of selection of habitat by the kestrels, within the facility, according to environmental conditions. Based on these predictions, we identified turbines, where kestrel’s presence was more likely to increase the risk of collision, and proposed a selective curtailment of these turbines. This mitigation measure could represent a step toward a win-win situation in which a selective curtailment allows stakeholders to continue producing renewable energy while reducing the collision risk of vulnerable bird populations.
UBIQUITIN-CONJUGATING ENZYME34 mediates pyrophosphatase AVP1 turnover and regulates abiotic stress responses in Arabidopsis
Authors: Xu Qiyu , Zhang Xingjian , Zhao Ruifeng , Li Shengjun , Liesche Johannes 
Published: January 2025

Abstract
Understanding the molecular mechanisms of abiotic stress responses in plants is instrumental for the development of climate-resilient crops. Key factors in abiotic stress responses, such as the proton-pumping pyrophosphatase (AVP1), have been identified, but their function and regulation remain elusive. Here, we explored the post-translational regulation of AVP1 by the ubiquitin-conjugating enzyme UBC34 and its relevance in the salt stress and phosphate starvation responses of Arabidopsis (Arabidopsis thaliana). Through in vitro and in vivo assays, we established that UBC34 interacts with and ubiquitylates AVP1. Mutant lines in which UBC34 was downregulated showed higher tolerance to salt and low inorganic phosphate (Pi) stresses, while we observed the opposite for plants overexpressing UBC34. Our results showed that UBC34 co-localizes with AVP1, and AVP1 activity is enhanced in the plasma membrane fractions of ubc34 mutants, indicating that UBC34 mediates the turnover of plasma membrane-localized AVP1. We also observed that UBC34 affects the apoplastic pH but not the vacuolar pH of root cells. Based on our results, we propose a mechanistic model in which UBC34 mediates AVP1 turnover at the plasma membrane of root epidermal cells. Downregulation of UBC34 under salt and phosphate starvation conditions enhances AVP1 activity, leading to a higher proton gradient available for sodium sequestration and phosphate uptake.
The clinical characteristics and treatment outcomes of patients with systemic polyarteritis nodosa: a single-centre study from India
Authors: Jha Avanish , R Chitra , Yadav Bijesh , Simon Betty , Mathew Ashish J , Mathew John , Thomas Meera , Goel Ruchika 
Published: January 2025

Abstract

Objective
To describe the clinical profile and compare the long-term outcomes of patients with systemic polyarteritis nodosa (S-PAN) treated with various treatment regimens at our centre in the last two decades.

Methods
Data regarding clinical presentation, treatment allocation, relapses and outcomes of patients fulfilling American College of Rheumatology (ACR) 1990 criteria for PAN in the last two decades were recorded from electronic medical records. Relapse-free survival and predictors were analysed using Kaplan–Meier survival statistics and regression analysis.

Results
Altogether, 53 patients, including two with hepatitis B infection, were included. Cutaneous lesions and peripheral neuropathy were the commonest manifestations. Most patients (64.2%) presented with a five-factor score (FFS) of 0. Disease-attributable hypertension and peripheral gangrene were the most common manifestations of severe disease. During a median follow-up period of 53.5 months in 49 patients who had a follow up, 43 (87.8%) attained complete response while 3 (6.1%) had a partial response. Among 46 patients who had follow up of more than 3 months, 19 (41.3%) patients relapsed at a median duration of 82 (interquartile range 36.3–127.7) months. The relapse-free survival in patients who received induction with mycophenolate (n = 26) was comparable to that with cyclophosphamide (n = 21) [adjusted hazard ratio (HR): 0.68]. Smoking history was an independent predictor of relapse (HR = 6.28, P = 0.013) while age was protective (HR = 0.94, P = 0.015). Overall, fatality was observed in 5 (10%) patients. FFS and BVAS at 3 months were among the predictors of mortality.

Conclusion
In our cohort of S-PAN, relapses were observed in 41.3% of patients. Mycophenolate was similar to cyclophosphamide in maintaining relapse-free survival. Only 10% fatality was recorded. FFS and BVAS at 3 months were predictors of mortality.
Association of total testosterone levels with cardiometabolic diseases in men with erectile dysfunction
Authors: Chen Bing-Tau , Tsai Ping-Ju , Jiann Bang-Ping 
Published: January 2025

Abstract

Background
Both serum testosterone (T) levels and erectile dysfunction (ED) are associated with systemic diseases in men and ED is the most common presenting symptom of hypogonadism.

Aim
To evaluate the association of serum total testosterone (TT) levels with cardiometabolic diseases in men with ED.

Methods
Serum endogenous TT levels were determined to evaluate their associations with cardiometabolic diseases in men with ED in outpatient clinics. Participants were divided into hypogonadal with TT &lt; 350 ng/dL (12.1 nmol/L) and eugonadal groups, as well as into four equal quartiles based on TT levels. The Framingham risk score was used to estimate individual 10-year coronary heart disease (CHD) risk.

Main Outcome Measures
Cardiometabolic factors included obesity, diabetes mellitus (DM), hypertension (HT), dyslipidemia, and the Framingham risk score.

Results
From 2010 to 2021, a total of 4467 subjects with ED were consecutively recruited for this study, and 3909 subjects’ (87.5%) data with a mean age of 53.0 ± 12.9 (20.0–88.0) years had data eligible for analysis. Testosterone levels declined with age and a higher body mass index (BMI) was associated with lower T levels across all age groups (P &lt; .001). Compared to the eugonadal group, the hypogonadal group was older and had a higher BMI and more cardiometabolic diseases (all P &lt; .01). In multivariate analysis, odds ratio (OR) for hypogonadism was highest in men with obesity (2.51), followed by age group of ≥70 years (2.32), DM (1.59), HT (1.41), and dyslipidemia (1.26). Compared with the lowest TT quartile, higher quartiles of TT had significantly lower risk for cardiometabolic diseases (all P &lt; .001). Among men over 50 yrs, hypogonadal men had a higher 10-year CHD risk than eugonadal men as predicted by the Framingham risk score (P &lt; .001).

Clinical implications
Our results highlight the value of determining TT levels in men with ED because of their association with cardiometabolic diseases and the potential benefits of T therapy for improving men’s health.

Strengths and Limitations
Strengths of this study include a relatively large sample and detailed medical history collection. Limitations included a small portion of subjects with repeat TT tests, and the lack of data on free T and bioavailable T levels, and single-site recruitment.

Conclusions
TT levels are independently associated with cardiometabolic diseases including obesity, DM, HT, and dyslipidemia, and indicate a higher risk for CHD in men with ED. Measuring TT levels in men with ED presents an opportunity to improve overall health and reduce CV risk.
Shining disco: shedding light into the systematics of the family Discodorididae (Gastropoda: Nudibranchia)
Authors: Fernández-Vilert Robert , Arnedo Miquel A , Salvador Xavi , Valdés Ángel , Schrödl Michael , Moles Juan 
Published: January 2025

Abstract
The evolutionary relationships among genera within the nudibranch family Discodorididae remain poorly understood, with comprehensive molecular studies still largely absent. Discodoris, the most species-rich genus within this family, has historically represented a wastebasket taxon where species with ‘discodoridid’ morphology were placed. In this study, we present molecular data to evaluate the taxonomic classification of the family and to investigate potential (pseudo)cryptic diversity. Our molecular analyses comprised a multilocus phylogenetic analysis of 199 specimens, including 20 type species. The dataset included 142 specimens belonging to Discodorididae, 24 from Dorididae, and 33 outgroup taxa. A total of 52 specimens from 30 different species of Discodorididae, including six type taxa, were sequenced from the Mediterranean Sea, Eastern Atlantic Ocean, and Central and South America. Phylogenetic analyses recovered the monophyly of the family Discodorididae but including the doridid Aphelodoris, revealing evidence of hidden diversity in several genera such as Taringa, Tayuva, Paradoris, and Geitodoris. Our study unveiled the paraphyly of the genera Discodoris and Diaulula, which warrant a critical appraisal of their morphology. Overall, we provide relevant molecular information to infer the most complete phylogeny of Discodorididae to date and identify new questions for future studies.
Amplitude and Phase Changes in Electrocochleographic Real-Time Recordings During Cochlear Implantation and Its Relation to Pre- and Postoperative Hearing
Authors: Dalbert Adrian , Bester Christofer , Collins Aaron , Razmovski Tayla , Gerard Jean-Marc , O’Leary Stephen 
Published: January 2025

Background
The aim of this study was to relate response patterns of electrocochleography (ECochG) recordings during cochlear implantation to pre- and postoperative hearing.

Methods
Thirty subjects with either flat (FA, n = 9) or sloping (SA, n = 21) audiograms before cochlear implantation were prospectively included. Real-time ECochG recordings were conducted via the cochlear implant. The difference curve (DIF) signal of the ECochG recordings was analyzed regarding alteration of the waveform, amplitude changes, and relative phase shifts during insertion.

Results
Five subjects (56%) with FA and 13 (62%) with SA exhibited DIF signal drops in the early phase of the insertion. In subjects with FA, alterations of the DIF signal waveform in the early phase of the insertion occurred in 8 subjects (90%), whereas such changes were detectable in only 2 out of 21 subjects (10%) with SA (p < 0.001). DIF signal drops with relative phase shifts of >0.7 radians but without alterations of the waveform occurred in 5 subjects (56%) with FA and 11 (52%) with SA. Such drops were associated with larger postoperative hearing losses than DIF signal drops without phase changes in both groups (FA: 43 versus 20 dB, p = 0.045; SA: 30 versus 14 dB, p = 0.001).

Conclusion
Residual cochlear function in basal regions leads to alteration of the DIF signal waveform during insertion, probably not associated with cochlear injury. A decrease of the DIF signal amplitude with a simultaneous relative phase shift but no alteration of the waveform is associated with greater loss of residual hearing independent from the preoperative hearing.
Utility of Multiparametric Breast MRI Radiomics to Predict Cyclin D1 and TGF-β1 Expression
Authors: Zheng Mengying , Xu Jiaqi , Yu Shujie , Zhao Zhenhua , Zhang Yu , Wei Mingzhu 
Published: January 2025

Objective:
To develop a machine learning model that integrates clinical features and multisequence MRI radiomics for noninvasively predicting the expression status of prognostic-related factors cyclin D1 and TGF-β1 in breast cancer, providing additional information for the clinical development of personalized treatment plans.

Methods:
A total of 123 breast cancer patients confirmed by surgical pathology were retrospectively enrolled in our Hospital from January 2016 to July 2022. The patients were randomly divided into a training group (87 cases) and a validation group (36 cases). Preoperative routine and dynamic contrast-enhanced magnetic resonance imaging scans of the breast were performed for treatment subjects. The region of interest was manually outlined, and texture features were extracted using AK software. Subsequently, the LASSO algorithm was employed for dimensionality reduction and feature selection to establish the MRI radiomics labels. The diagnostic efficacy and clinical value were assessed through receiver operating characteristic (ROC) curve analysis and decision curve analysis (DCA).

Results:
In the cyclin D1 cohort, the area under the receiver operating characteristic (ROC) curve in the clinical prediction model training and validation groups was 0.738 and 0.656, respectively. The multisequence MRI radiomics prediction model achieved an AUC of 0.874 and 0.753 in these respective groups, while the combined prediction model yielded an AUC of 0.892 and 0.785. In the TGF-β1 cohort, the ROC AUC for the clinical prediction model was found to be 0.693 and 0.645 in the training and validation groups, respectively. For the multiseries MRI radiomics prediction model, it achieved an AUC of 0.875 and 0.760 in these respective groups; whereas for the combined prediction model, it reached an AUC of 0.904 and 0.833. Decision curve analysis (DCA) demonstrated that both cohorts indicated a higher clinical application value for the combined prediction model compared with both individual models—clinical prediction model alone or radiomics model.

Conclusion:
The integration of clinical features and multisequence MRI radiomics in a combined modeling approach holds significant predictive value for the expression status of cyclin D1 and TGF-β1. The model provides a noninvasive, dynamic evaluation method that provides effective guidance for clinical treatment.