bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration and Validation of Lead Molecules against Yellow Fever
through High Throughput Virtual Screening and Molecular Dynamics
Simulation
Authors: Kathiresan Nachammai , Pandi Sangavi , Sahul Thameema Parveen , Subbaraj Gowtham Kumar , Ganapathy Priyanka , Chandrashekar Kirubhanand , Kulanthaivel Langeswaran 
Published: February 2023

Background:
Yellow fever (YF) is a mosquito-borne flaviviral hemorrhagic fever (VHF) that
causes severe hepatitis, renal failure, bleeding, and quick terminal events such as shock and multi-organ
failure. There are currently no particular anti-viral medications for the management of the YF virus
(YFV). Despite the availability of a commercial YFV vaccination, there are roughly 30,000 fatalities
globally each year, with instances rising over the previous 20 years. After being translocated into the endoplasmic
reticulum lumen, glycosylated NS1 resides as a membrane-associated dimer, where it is required
for viral genome replication. The secreted hexamer NS1 has a role in immune evasion and pathogenesis
and has been discovered as a possible diagnostic marker for the early identification of viral infections.

Objective:
The main aim of this study is to analyze the small molecule as a potent drug candidate against
the target NS1 protein.

Methods:
In this study, Computational approaches, including high throughput virtual screening, molecular
docking, and dynamics simulation, were carried out against the target NS1 protein using three different
chemical libraries Enamine, Asinex, and NCI. The selected lead compounds were validated through
HOMO-LUMO analysis, ADME prediction, and Toxicity parameters to analyze the biological and pharmacological
properties of the lead small molecules.

Results:
From the result, it was concluded that the leads possessed the highest docking scores, interacting
with the binding residues, and were stable in the simulation period.

Conclusion:
Overall findings revealed that the lead three small molecules could act as the potential drug
candidate for the target NS1 protein to inhibit the diseasing efficacy of Yellow fever.
Forecasting of Permeate Conductivity using MLR and ANN Methods of
Boujdour Seawater Reverse Osmosis Desalination Plant
Authors: Kherraf Siham , Bakkouche Chaymae , Barhmi Soukaina , Mabrouki Jamal , El Hajjaji Souad , Elfatni Omkeltoum , Dhiba Driss , Maissine Khlifa 
Published: February 2023

Background:
For many years, seawater desalination technique has been operational to deal
with water scarcity. In Boujdour region, located near the Atlantic Ocean southwest of Morocco, most
water drinking is produced by a reverse osmosis seawater desalination plant. The permeate conductivity
prediction is used to evaluate the performance of desalination plants.

Objective:
The present paper focuses on the modeling and comparison of the Artificial Neural Network
(ANN) and Multiple Linear Regression (MLR) for the prediction of permeate conductivity for a one-year
period.

Methods:
Six input variables are considered, including turbidity, temperature, pH, feed conductivity, feed
flow, and transmembrane pressure (TMP). Firstly, the MLR identifies the most important variables influencing
the permeate conductivity with the aim of developing a regression model for the dependent and
independent parameters. Secondly, the ANN method is examined to analyze the performance of desalination
plant. A study of the effect of the number of neurons and the number of hidden layers on the efficiency
of the neural network has been made.

Results and Conclusion:
Results confirm that the MLR and ANN models forecast the permeate conductivity
with a suitable coordination coefficient of the real and predicted values. ANN model has been successfully
tested for reliability with a correlation coefficient R2 of 99.097% and a mean square error (MSE)
of 0.002607.
Preclinical Effects of Melatonin on the Development of Ehrlich's Tumor: A Biochemical, Cognitive, and Molecular Approach
Authors: Lopes Ivan Pereira , Bagatela Bianca Souza , Lopes Andrey Pereira , Silveira Elaine Ferreira , Petri Giuliana , Santos Jose Francisco Ramos , Perez Matheus Moreira , da Veiga Glaucia Luciano , da Costa Aguiar Alves Beatriz , Perazzo Fabio Ferreira , Feder David , Fonseca Fernando Luiz Affonso 
Published: February 2023

Background:
It has already been shown that melatonin is an antitumoral molecule that
affects malignant cells via some mechanisms. The benefit played by this hormone on cancer is due
to its antioxidant effects.

Objective:
This study aimed to evaluate the preclinical effects of melatonin in mice with the Ehrlich
ascites tumor.

Methods:
Twenty Balb/c male mice with Ehrlich tumor were treated with different melatonin doses.
Their inflammatory and oxidative stress were accessed by gene expression. Hepatotoxicity and
hematological parameters were also evaluated through biochemical analyses. Animal welfare was
analysed weekly from the categories guided by the NC3Rs.

Results:
Gene expression analyses have shown that only Tnfα and Sod1 were expressed in all
groups studied. Only the M-3 group showed increased Tnfα expression compared to the control.
All groups treated with melatonin showed decreased Sod1 expression compared to the control. No
signs of hepatotoxicity were caused by any of the melatonin doses used in the treatment

Conclusion:
In animals with Ehrlich´s tumor treated with melatonin, a decrease in oxidative
stress, an amelioration in welfare and in cognitive tasks could be observed, even if the treatment
has not reduced the size of the tumor itself. In parallel with the already patented use of melatonin
in the treatment of sleep disorders or chronic kidney disease, our results propose its use to improve
the general well-being of breast cancer patients.
Comparison of Learning Facilitated by Traditional and Virtual Case Studies for Teaching the Nursing Approach to Care
Authors: Qaisar Rabia , Bouzoubaa Hind , Lajane Halima , Lamiri Abderrahmane , Benchadlia Fatimazahra , Abidi Omar , Khyati Abderrahim 
Published: February 2023

Aim:
The objective of this study is to investigate the adoption of these two strategies for teaching the steps of the care process to Moroccan nursing students. We attempt to answer the following questions: What is the preference of nursing students between traditional case studies and virtual case studies? What are their suggestions for improving teaching practices? According to their point of view, which of the teaching strategies is more conducive to the appropriation of knowledge and the development of skills related to the care process?

Background:
Case-based learning has long been one of the active teaching strategies widely used by nursing educators. However, the constraints inherent to traditional case study learning have prompted educators to seek alternative teaching practices. Today, virtual case studies are recognised as one of the most recommended and innovative teaching approaches to address these constraints in the nursing context.

Objective:
the present study aims to explore students' perceptions of traditional case studies and virtual case studies as facilitated learning methods for teaching the nursing process.

Methods:
We conducted a questionnaire survey at the Higher Institute of Nursing Professions and Health Techniques Casablanca in 2021 among first-year polyvalent nursing students. The course ‘Conceptualization and Care Planning’ was taught based on these two different pedagogies.

Results:
Comparing the means via a t-test of the paired samples showed that there was a significant difference for all items (p-value&lt;0.005) between learning facilitated by traditional case studies and virtual case studies.

Conclusion:
These results demonstrate that virtual case studies are an innovative and well-received educational tool for nursing students compared to traditional case studies.
Sustainable Construction Materials: Recycled Aggregate Concrete from Known Concrete Strength Debris
Authors: Issa Camille A. , Hilal Georgio 
Published: February 2023

Background:
Landfills receive construction and demolition wastes (CDW) that are the debris generated during the construction, renovation, and demolition of buildings, roads, and bridges. CDW are resources that could be used in new construction projects, thus eliminating the need for virgin materials to be mined and processed.

Objective:
The main objective of this study is to develop a novel investigation of the mechanical behavior of concrete mix design incorporating recycled aggregate concrete (RAC) from casted concrete debris of known compressive strength while meticulously monitoring the effective water-to-cement ratio.

Methods:
The following four variables were monitored while performing the concrete mix design: the percentage of recycled coarse aggregates (RCA), the percentage of recycled fine aggregates (RFA), the gradation of the recycled material used, and the original compressive strength of the casted concrete debris. The initial strength and size of the debris versus the quantity of usable recycled materials obtained were investigated. The consequence of the utilization of each variable in the final concrete mix was determined. The mechanical properties investigated were the compressive strength, flexural strength, and modulus of elasticity of concrete made with different percentages of recycled materials.

Results:
The result of this study is achieving an optimum concrete mix design that also results in minimizing the negative impact on the environment by reducing the amount of CDW being dumped in landfills.

Conclusion:
The combination of both recycled coarse and recycled fine aggregates resulted in an increase in mechanical performance of the concrete while enhancing the environmental value of the final material.
Depression and Quality of Life among Women Hospitalized during COVID-19 Pandemic
Authors: Yusefi Ali Reza , Davarani Esmat Rezabeigi , Kavosi Zahra , Mehralian Gholamhossein 
Published: February 2023

Introduction:
The outbreak of the new coronavirus (COVID-19) can lead to the development of several mental disorders. Women are an important part of any society, and psychological factors can affect their quality of life. The present study aimed to investigate the depression level among hospitalized women and its relationship with their quality of life during the COVID-19 pandemic in 2021.

Methods:
This descriptive-analytical study was conducted on 465 women admitted to public educational hospitals affiliated with the Minister of Health, Iran. The data collection tools were the Goldberg Depression Scale and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) Questionnaire. Descriptive and inferential statistical methods were used to analyze the data by applying SPSS software version 23.

Results:
According to the results, 48.60% of the women were mentally healthy. While 15.27% of them were more likely to develop depression, 13.12% of the others were borderline depressed. At the same time, 12.69% of the women who participated in the study suffered from a mild to moderate level of depression, 7.74% of women had moderate to severe depression, and 2.58% of the rest tolerated severe depression. Other results show that the mean score of quality of life (QOL) of the women was 58.49±11.51 (out of 120). Moreover, a significant and inverse correlation between depression and QOL was observed among the studied women (r=-0.564, P<0.001). Statistically significant relationships between depression and the variables of age (P=0.007), place of residence (P=0.04), marital status (P=0.006), level of education (P<0.001), and income level (P=0.03) were also observed. Moreover, there was also a statistically significant relationship between women's QOL and their marital status (P=0.02).

Conclusion:
According to the results, providing social support and establishing effective communication based on mutual interaction among hospitalized women and healthcare workers can be recommended to decrease their level of depressive disorder and enhance their QOL.
Mental Health Status and the Readiness of Nursing Students to Serve During the COVID-19 Pandemic
Authors: Brajshori Naime , Paice Leonora , Alloqi Tahirbegolli Iliriana , Dervishaj Ukehaxhaj Antigona , Kryeziu Blerta , Gogebakan Yildiz Derya , Hoti Flaka , Osmani Shkelzen , Tahirbegolli Bernard 
Published: February 2023

Aims:
This study aims to assess the state of mental health of nursing students in Kosovo and their willingness to provide professional health services for individuals at risk during the COVID-19 pandemic.

Methods:
In this cross-sectional survey, undergraduate nursing students from three higher education institutions in Kosovo participate from May 25, 2020, to June 5, 2020. Data was collected through a structured, anonymous, self-directed questionnaire via the online platform-google forms. Questions about nursing knowledge, skills and competencies, and willingness to work, if necessary, in healthcare facilities in Kosovo before graduation during the COVID-19 pandemic, were organised according to the Likert scale.

Results:
Four hundred and seventy-two nursing students (82% female; and mean age 20.3±1.8 years) participated in the study. 18.2% of students required further evaluation for depression, 48.3% for anxiety, and 30.7% for stress. 77.8% of students agreed that they had acquired sufficient knowledge, 80.6% that they had sufficient skills, and 75.9% that they had sufficient competencies, during their studies, to work as nurses. Female students had higher stress (8.55±4.06) and anxiety scores (6.65±4.08) compared to their male counterparts (7.46±4.35; and 5.02±4.07; respectively) (p<0.05). There was no statistically significant difference among categories of stress, anxiety and depression, and nursing student’s willingness to work or not during COVID-19 pandemic (p>0.05).

Conclusion:
Most nursing students in Kosovo appear ready and willing to join qualified nurses in healthcare institutions in delivering health services during the COVID-19 pandemic.

Highlights:
Most nursing students are willing to provide health services during the pandemic.

The female students had higher stress and anxiety scores than their counterparts.

This study discovered that students needed psychological support during the pandemic.

Serving during the pandemic will put into practice problem-solving skills.
Terpenoids and Triterpenoid Saponins: Future Treatment for Depression
Authors: Mando Zaynab , Al Zarzour Ragdhaa Hamdan , Alshehade Salah , Afzan Adlin , Shaari Khozirah , Hassan Zurina , Mahror Norlia , Zakaria Fauziahanim 
Published: February 2023

Background:
Depression is a crippling mental disorder with high prevalence around the
world. The available clinical antidepressants have been effective to a certain degree, and different
side effects have limited their application. This leads to the necessity of finding new treatments.
Herbal plants are a substantial source of new drug leads. Terpenoid compounds are secondary metabolites
representing an enormous category of structures found commonly in plants either as aglycones
or attached to sugar moieties. These phytochemicals have been extensively studied for their
various biological effects, and several have been investigated for potential therapeutic effects in the
treatment of depression.

Aim:
This review aims to highlight the current knowledge on some terpenoids and triterpenoid
saponins as potential antidepressant agents and their mechanisms of action, which may provide a
better understanding of the potential antidepressant-like effects of these compounds and lead to the
development of auspicious molecules with high efficiency and low side effects for depressive disorders
treatment.

Methods:
A total of 16 plants containing antidepressant agents are reviewed in this article. 9 terpenoids
and 23 triterpenoid saponins compounds have been reported to becommonly found in plant
extracts, indicating potential use for depression. To enhance the datum of this review, the mechanism
of action for the candidate compounds has been predicted via functional enrichment analysis.

Results:
The behavioural and neurochemical effects, as well as the possible mechanisms of action,
have been evaluated in rodents by different predictive models of depression, mainly the acute
stress models of the forced swimming test (FST) and tail suspension test (TST). The involved
mechanisms include enhancing monoamine neurotransmitters, ameliorating brain-derived neurotrophic
factor (BDNF), and normalizing the hypothalamus-pituitary-adrenal (HPA) axis. Preclinical
studies support the potential antidepressant activities of some terpenoid compounds. Furthermore,
the functional enrichment analysis has confirmed the previous pre-clinical findings and predicted
further mechanisms of action, including cellular calcium ion homeostasis, cellular response
to dopamine, endocrine resistance, and regulating GABAergic, serotonergic, glutamatergic, and
dopaminergic synapse, bedsides neurotransmitter reuptake.

Conclusion:
Terpenoids and triterpenoid saponins provide a large number of natural compounds.
This review sheds light on terpenoids and triterpenoid saponins compounds with antidepressantlike
activity and their potential mechanisms of action. However, more evaluations are required to
confirm that these compounds are promising for discovering antidepressant drugs.
Exploring the Perceptions of mHealth Interventions for the Prevention of Common Mental Disorders in University Students in Singapore: Qualitative Study
Authors: Salamanca-Sanabria Alicia , Jabir Ahmad Ishqi , Lin Xiaowen , Alattas Aishah , Kocaballi A Baki , Lee Jimmy , Kowatsch Tobias , Tudor Car Lorainne 
Published: February 2023

Background
Mental health interventions delivered through mobile health (mHealth) technologies can increase the access to mental health services, especially among university students. The development of mHealth intervention is complex and needs to be context sensitive. There is currently limited evidence on the perceptions, needs, and barriers related to these interventions in the Southeast Asian context.

Objective
This qualitative study aimed to explore the perception of university students and mental health supporters in Singapore about mental health services, campaigns, and mHealth interventions with a focus on conversational agent interventions for the prevention of common mental disorders such as anxiety and depression.

Methods
We conducted 6 web-based focus group discussions with 30 university students and one-to-one web-based interviews with 11 mental health supporters consisting of faculty members tasked with student pastoral care, a mental health first aider, counselors, psychologists, a clinical psychologist, and a psychiatrist. The qualitative analysis followed a reflexive thematic analysis framework.

Results
The following 6 main themes were identified: a healthy lifestyle as students, access to mental health services, the role of mental health promotion campaigns, preferred mHealth engagement features, factors that influence the adoption of mHealth interventions, and cultural relevance of mHealth interventions. The interpretation of our findings shows that students were reluctant to use mental health services because of the fear of stigma and a possible lack of confidentiality.

Conclusions
Study participants viewed mHealth interventions for mental health as part of a blended intervention. They also felt that future mental health mHealth interventions should be more personalized and capable of managing adverse events such as suicidal ideation.
Effect of the number of physiologically mature maintenance leaves and the frequency of foliar fertilizer application on the growth of Empoasca, weeds, and the yield of clone GMB 7 tea crop (Camellia sinensis (L.) O. Kuntze)
Authors: Sucherman Odih 
Published: February 2023

The objective of this research was to study the interaction effect between the number of physiologically mature maintenance leaves on tipping and the frequency of application foliar fertilizer application on the development of the main pest Empoasca, weeds and the yield of GMB 7 tea clone. The experiment was conÂ­ducted at Gambung Estate, block A4, ReÂ­search Institute Tea and Cinchona, Mekarsari Village, Pasirjambu Subdistrict, Bandung Regency, with altitudeÂ aboutÂ 1.300 m above sea level. The average rainfall was 3.035 mm/year and the type of rainfall is B according to Schmidt and Fergusson (1951). The soil type is Andisol with pH 5,9. The experiment was done from DecemÂ­ber 2011 until July 2012. The experiment has factorial Randomized Block Design (RBD) with three replications. The first factor is physioÂ­logically mature maintenance leaves on tipping (A) with 3 treatments: a0 = 3 leaves, a1 = 5 leaves and a2 = 7 leaves. The second factor is the application of follar fertilizer (B) with three treatments: b0 = without application, b1 = one application and b2 = two applications. The result showed that no interaction between the number of physiologically mature maintenance leaves and the frequency of foliar fertilizer application on the attack intensity of Empoasca. The interaction between five physiologically mature maintenance leaves and one application of folliar fertilizer treatment were effective to control pest and weeds. The interaction hapÂ­pened between the number of physiologically mature maintenance leaves on tipping and the frequency application of foliar fertilizer on yield at 10 and 12 weeks after determined the physiologically mature maintenance leaves. The average of LAI on five physiologically mature maintenance leaves and one application of folliar fertilizer treatment were 3,0087 with regression Å¶-a1b1 = -0,1923 + 0,0237 X; R^2 = 0,8979 were effective to control Empoasca, weeds and to increase the yield.
Ensamblando el cibercolegio
Authors: Pereira-García Alexander 
Published: February 2023

El artículo presenta resultados de una investigación orientada hacia la comprensión de las articulaciones entre educación y tecnologías digitales. Este objetivo se desarrolló a partir del análisis del proceso de producción del cibercolegio, una estrategia planteada por el Colegio Enrique Olaya Herrera, institución educativa del sector público de Bogotá, desde la cual se otorgó relevancia a las tecnologías digitales como componente estructural del proyecto educativo. Metodológicamente se abordó la revisión documental y un enfoque de tipo etnográfico basado en la lógica de seguir a los actores y actantes heterogéneos involucrados, con el fin de entender las transiciones y asociaciones ocurridas, así como las diferentes fases del proceso. Como resultado se observó la incorporación gradual del discurso sobre las tecnologías de la información y la comunicación, primero en los documentos oficiales de política educativa y, posteriormente, en las prácticas escolares, evidenciándose la popularización de los imaginarios y supuestos vinculados con estas tecnologías. Lo anterior supuso el desarrollo de controversias, encuentros y desencuentros entre una multiplicidad de actores vinculados al escenario escolar. La conclusión principal del estudio plantea que, tanto la construcción de significados asignados a las tecnologías de la información y la comunicación por parte de los actores involucrados, como la articulación entre políticas, normas, documentos, discursos, prácticas sociales y humanos, determinan el curso del ensamblaje del cibercolegio y las dificultades para su pretendida estabilización y, en tanto, la justificación de un proyecto de mejoramiento de la calidad educativa.