bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Progress in Inorganic Afterglow Materials: Mechanisms, Persistent Luminescent Properties, Modulating Methods, and Bioimaging Applications
Authors: Yang Lu , Gai Shili , Ding He , Yang Dan , Feng Lili , Yang Piaoping 
Published: January 2023

AbstractPersistent luminescence (PL) is a distinctive optical phenomenon with long‐lasting afterglow emissions after the cessation of excitation, thus emerging huge prospects in the applications of anti‐counterfeiting, information or data storage, photocatalysis, sensing, and bioimaging. In this regard, it is of great importance to optimize the PL performance. Recently, no comprehensive literature review on inorganic persistent phosphors is reported to aid researchers in focusing on the systematic adjustment of afterglow properties based on reported progress made in recent ten years. Accordingly, the motivation of this work is to review the inorganic persistent phosphors that are of interest for the dopant and host selection criteria, the afterglow intensity, and multi‐color modulating methods, from the perspectives of composition optimization, defect engineering, and coordination environment of hosts. Then, X‐ray, light emitting diode (LED), ultraviolet (UV), and near‐infrared (NIR) excited PL imaging and multimodal imaging of persistent phosphors are introduced. Finally, the summary, challenge, outlook, and future development direction in this field are provided. With the profound influence of the afterglow materials, it is believed that this review will be a guideline for the design, synthesis, and optical performance optimization of persistent materials in the future.
Self‐Assembly in “Matrix‐Free” Functionalized Boron Nitride Sheets as Free‐Standing Thin Film Sieves for Stable Forward Osmosis and Robust Dye Removal Applications
Authors: Samantaray Paresh Kumar , Sen Gupta Ria , Bose Suryasarathi 
Published: January 2023

AbstractHerein, a facile “matrix‐free” thin film membrane strategy is reported that exploits polymer brushes grafted hydroxyl‐functionalized hexagonal boron nitride nanosheets (h‐BNOH) toward forward osmosis desalination and dye rejection application. The functionalized nanosheets are characterized using Fourier transform infrared spectroscopy (FTIR), high‐resolution transmission electron microscopy (HRTEM), X‐ray diffraction (XRD), Nuclear magnetic resonance (NMR), UV–visible spectrophotometry, and thermogravimetric analysis (TGA). Covalently functionalized nanosheets of poly methyl methacrylate (PMMA) termed as boron nitride grafted PMMA (BN‐g‐PMMA) obtained via RAFT polymerization are deployed toward “matrix‐free” nanocomposite membranes. The membranes exhibit ≈5260 L /m−2 h−1 at a moderate pressure of 0.21 MPa in cross‐flow mode and a 70% of flux retention ratio against bovine serum albumin as protein foulant. The matrix‐free membranes exhibit ≈93% salt rejection for NaCl and >99% rejection for MgCl2 and Ca(NO3)2·4H2O for 2000 ppm draw solution (water TDS benchmark for domestic purifiers) while 90% NaCl, and >96% rejection for MgCl2 and Ca(NO3)2·4H2O for 5000 ppm draw. In simulated domestic water salinity, 97.8% rejection is observed for 2000 ppm and 94.5% for 5000 ppm draw solution, respectively. The matrix‐free membranes also achieve almost 100% dye rejection for eight model dye pollutants at 1 ppm and >96.6% for 10 ppm concentrations, respectively.
Design Strategies and Recent Advancements for Low‐Temperature Aqueous Rechargeable Energy Storage
Authors: Zhu Kunjie , Sun Zhiqin , Li Zhaopeng , Liu Pei , Li Haixia , Jiao Lifang 
Published: January 2023

AbstractAqueous rechargeable energy storage (ARES) has received tremendous attention in recent years due to its intrinsic merits of low cost, high safety, and environmental friendliness. However, the relatively higher freezing point of conventional aqueous electrolytes results in sluggish kinetics and inferior ion transport efficiency under low temperature, severely restricting their further development and practical applications. In order to deal with the existing issues, the design principles to develop low‐temperature ARES with excellent performance are discussed in‐depth and precisely classified, primarily with respect to electrode modification and electrolyte regulation. In addition, the related studies about low‐temperature ARES are systematically and comprehensively summarized. Finally, the critical bottlenecks, some suggestions, and future perspectives are also provided, which will help to address the current challenges of low‐temperature ARES. This review is expected to deepen the fundamental understanding of low‐temperature ARES and offer guiding suggestions to boost their future applications.
The worldwide costs of dementia in 2019
Authors: Wimo Anders , Seeher Katrin , Cataldi Rodrigo , Cyhlarova Eva , Dielemann Joseph L. , Frisell Oskar , Guerchet Maëlenn , Jönsson Linus , Malaha Angeladine Kenne , Nichols Emma , Pedroza Paola , Prince Martin , Knapp Martin , Dua Tarun 
Published: January 2023

AbstractIntroductionDementia is a leading cause of death and disability globally. Estimating total societal costs demonstrates the wide impact of dementia and its main direct and indirect economic components.MethodsWe constructed a global cost model for dementia, presenting costs as cumulated global and regional costs.ResultsIn 2019, the annual global societal costs of dementia were estimated at US $1313.4 billion for 55.2 million people with dementia, corresponding to US $23,796 per person with dementia. Of the total, US $213.2 billion (16%) were direct medical costs, US $448.7 billion (34%) direct social sector costs (including long‐term care), and US $651.4 billion (50%) costs of informal care.DiscussionThe huge costs of dementia worldwide place enormous strains on care systems and families alike. Although most people with dementia live in low‐ and middle‐income countries, highest total and per‐person costs are seen in high‐income countries.Highlights
Global economic costs of dementia were estimated to reach US $1313.4 in 2019.
Sixty‐one percent of people with dementia live in low‐and middle‐income countries, whereas 74% of the costs occur in high‐income countries.
The impact of informal care accounts for about 50% of the global costs.
The development of a long‐term care infrastructure is a great challenge for low‐and middle‐income countries.
There is a great need for more cost studies, particularly in low‐ and middle‐income countries.
Discussions of a framework for global cost comparisons are needed.
Designed Iron Catalysts for Allylic C−H Functionalization of Propylene and Simple Olefins
Authors: Wang Ruihan , Wang Yidong , Ding Ruiqi , Staub Parker B. , Zhao Christopher Z. , Liu Peng , Wang Yi‐Ming 
Published: January 2023

AbstractPropylene gas is produced worldwide by steam cracking on million‐metric‐ton scale per year. It serves as a valuable starting material for π‐bond functionalization but is rarely applied in transition metal‐catalyzed allylic C−H functionalization for fine chemical synthesis. Herein, we report that a newly‐developed cationic cyclopentadienyliron dicarbonyl complex allows for the conversion of propylene to its allylic C−C bond coupling products under catalytic conditions. This approach was also found applicable to the allylic functionalization of simple α‐olefins with distinctive branched selectivity. Experimental and computational mechanistic studies supported the allylic deprotonation of the metal‐coordinated alkene as the turnover‐limiting step and led to insights into the multifaceted roles of the newly designed ligand in promoting allylic C−H functionalization with enhanced reactivity and stereoselectivity.
Der Aufstieg der Trichloride Ermöglicht eine Verbesserte Chlortechnologie
Authors: Kleoff Merlin , Voßnacker Patrick , Riedel Sebastian 
Published: January 2023

AbstractChlor spielt eine zentrale Rolle bei der industriellen Herstellung zahlreicher Produkte von globaler Bedeutung. In jüngster Zeit haben sich Polychloride von einem Gebiet akademischen Interesses zu einem Forschungsthema mit enormem industriellen Potenzial entwickelt. In diesem Aufsatz wird der Wert von Trichloriden für die Chlorspeicherung und Chlorierungsreaktionen skizziert. Insbesondere die kostengünstige ionische Flüssigkeit [NEt3Me][Cl3] zeigt eine ähnliche und manchmal sogar vorteilhafte Reaktivität im Vergleich zu Chlorgas und bietet gleichzeitig ein besseres Sicherheitsprofil. Als Chlorspeicher eingesetzt, könnte [NEt3Me][Cl3] dazu beitragen, die derzeitigen Einschränkungen bei der Lagerung und dem Transport von Chlor in größeren Mengen zu überwinden. So könnten Trichloride zu einer Schlüsseltechnik für die Flexibilisierung der Chlorproduktion werden, die eine Nutzung erneuerbarer, aber schwankender elektrischer Energie ermöglicht. Da es sich bei dem geladenen Speicher, [NEt3Me][Cl3], um ein bewährtes Chlorierungsreagenz handelt, könnte es direkt für nachgelagerte Prozesse eingesetzt werden und den Weg zu einer praktischeren und sichereren Chlorindustrie ebnen.
Bor‐Zentrierte Lewis‐Supersäuren durch Redoxaktive Liganden: Anwendung in der C‐F‐ und S‐F‐Bindungsaktivierung
Authors: Köring Laura , Stepen Arne , Birenheide Bernhard , Barth Simon , Leskov Maxim , Schoch Roland , Krämer Felix , Breher Frank , Paradies Jan 
Published: January 2023

AbstractEine Reihe redox‐responsiver, Ferrocenyl‐substituierter Borane und Boronsäureester wurde dargestellt. Oxidation der Ferrocenyl‐Einheit zum entsprechenden Ferrocenium führte zu einer drastischen Erhöhung der Lewis‐Acidität, wobei sogar die des SbF5übertroffen wird. Dies wurde sowohl experimentell als auch durch quantenchemische Rechnungen untersucht. Die resultierenden, stark Lewis‐aciden Borverbindungen wurden für katalytische C‐F‐ und S‐F‐Aktivierung verwendet.
Towards Electrochemiluminescence Microscopy Exploration of Plasmonic‐Mediated Phenomena at the Single‐Nanoparticle Level
Authors: Scarabelli Leonardo 
Published: January 2023

AbstractThe rational design of functional plasmonic metasurfaces and metamaterials requires the development of high‐throughput characterization techniques compatible withoperandoconditions and capable of addressing single‐nanostructures. In their work, Wei et al. demonstrate the use of electrochemiluminescence microscopy to investigate the mechanism behind plasmon‐enhanced luminescence induced by gold nanostructures. The use of gold plasmonic arrays was exploited to achieve the rapid spectroscopic evaluation of all the individual nanostructures, and the correlation of the results with high‐ resolution electron microscopy analysis, guaranteeing a strict one‐to‐one correspondence. The authors were able to identify two different mechanisms for the enhancement of [Ru(bpy)3]2+‐tri‐n‐propylamine electrochemiluminescence mediated by single gold nanoparticles and by small plasmonic clusters. In the future, the proposed characterization could be used for the rapid andin situspectroscopic analysis of more complex plasmonic nanostructures and metasurfaces.
Needs assessment of essential anatomy: The perspective of adult primary care resident physicians
Authors: Hankin Mark H. , Harmon Derek J. , Martindale James R. , Niculescu Iuliana , Aschmetat Adrienne , Mertens Amy N. , Hanke Rachel E. , Koo Andrew S. , Kraus Anthony E. , Payne James A. , Feldman Michael J. , Soltero Mariscal Enrique 
Published: January 2023

AbstractCurricular development and modification involve first identifying a problem and then performing a needs assessment, which can guide the design of curricular components. Pedagogical changes, coupled with reductions in curricular time for gross anatomy, pose challenges and impose restrictions within medical school curricula. In order to make anatomy education effective and efficient, it is important to determine the anatomy considered essential for medical education through a targeted needs assessment. In this study, 50 adult primary care resident physicians in family medicine (FM) and internal medicine (IM) were surveyed to assess the importance of 907 anatomical structures, or groups of structures, across all anatomical regions from a curated list based on the boldface terms in four primary anatomy texts. There were no statistically significant differences in the ratings of structures between the two groups for any anatomical region. In total, 17.0% of structures, or groups of structures, were classified as essential, 58.0% as more important, 24.4% as less important, and 0.7% as not important. FM residents rated tissues classified as skeleton, nerves, fasciae, anatomical spaces, blood vessels, lymphatics, and surface anatomy (p < 0.0001) significantly higher than IM residents, but there were no differences in the rating of muscles or organs (p > 0.0056). It was notable that 100.0% of cranial nerves were classified as essential, and 94.5% of surface anatomy structures were classified as essential or more important. It is proposed that results of this study can serve to inform curricular development and revision.
Advancing Electrode Properties through Functionalization for Solid Oxide Cells Application: A Review
Authors: Dey Shoroshi , Chaudhary Saroj , Parvatalu Damaraju , Mukhopadhyay Madhumita , Sharma Abhijit Das , Mukhopadhyay Jayanta 
Published: January 2023

AbstractHydrogen energy has emerged as the only renewable which is capable of sustaining the prevalent energy crisis in conjunction with other intermittent sources. In this connection, solid oxide cell (SOC) is the most sustainable solid‐state devices capable of recycling and reproducing green hydrogen fuel. It is operable in reversible modes viz, fuel cell (FC) and electrolysis cell (EC). SOC is capable of engaging multiple fuels thereby promoting carbon neutral planet. The all‐solid design further augments the optimization of cost, efficiency, durability and endurance at higher temperature. Electrodes are therefore, an important component which is responsible for electrocatalytic processing of fuel and oxidant for higher recyclability of cell/stack. The present review article embarks a detailed overview on the past and present status of electrode composition, heterointerface engineering applicable for SOC's. Recent trends in electrode engineering and the possibilities for advancement in SOC is also reviewed with respect to both experimental and computational aspects.
Exponential finite‐time couple‐group consensus for agents in cooperative‐competitive networks via pinning method
Authors: Ji Lianghao , Wu Rong , Zhang Cuijuan , Yang Shasha , Li Huaqing 
Published: January 2023

AbstractThis paper investigates the exponential finite‐time couple‐group consensus problem for multi‐agent systems via pinning control method. Considering the hybrid cooperative and competitive interactions among the agents, a new nonlinear distributed control protocol is proposed. Under the pinning control scheme, the criteria for guaranteeing the system with weakly connected communication topology achieve exponential couple‐group consensus in finite time are obtained, and the pinning control strategies are presented as well. Furthermore, the results show that the settling time for the system to reach consensus is independent of the initial states of the agents. Finally, the correctness of our results is verified by some simulations.
Evidence from the Autism Transitions Research Project (2017–2022): Capstone review and services research recommendations
Authors: Roux Anne M. , Shea Lindsay L. , Steinberg Hillary , Rast Jessica E. , Anderson Kristy A. , Hotez Emily , Rosenau Kashia , Kuo Alice , Assing‐Murray Evva , Shattuck Paul T. 
Published: January 2023

AbstractFew funding sources have explicitly supported systems‐wide research to identify mechanisms for improving access, service delivery, outcomes and wellbeing for autistic transition‐age youth and young adults. We aimed to integrate findings from research produced through a five‐year federal Autism Transition Research Project (ATRP) cooperative agreement. This capstone review sought to: (1) map the body of scientific evidence that emerged from this federal award, and (2) identify remaining evidence gaps to inform future autism transition services research. We used scoping review methods to assess 31 ATRP‐funded published scientific studies. We charted study characteristics, topical domains, socio‐ecological levels of variables, focus on equity, and inclusion of autistic participants. We evaluated how these topics were addressed across studies to identify continued gaps in the evidence base. Compared to prior published reviews and research agendas, we found improvements in characterization of study participants, broader examination of socio‐ecological correlates, and examination of multiple outcome domains. However, we also identified continued deficits in inclusion of autistic study participants, use of multisectoral data, and research with a strong focus on equity. Our recommended priorities for autism transition services research to facilitate healthy life outcomes and wellbeing included: continued analysis of population‐level data and improved data infrastructure; development of service delivery methods and interventions that target marginalized groups; expanded research to inform improvements in the performance and coordination of complex service ecosystems that interface with autistic youth; and bolstering the roles of autistic research participants.
National and subnational burden of brain and central nervous system cancers in Iran, 1990–2019: Results from the global burden of disease study 2019
Authors: Mahdavi Mahdi , Moghaddam Sahar Saeedi , Abbasi‐Kangevari Mohsen , Mohammadi Esmaeil , Shobeiri Parnian , Sharifi Guive , Jafari Ali , Rezaei Negar , Ebrahimi Narges , Rezaei Nazila , Ghamari Seyyed‐Hadi , Malekpour Mohammad‐Reza , Khalili Majid , Larijani Bagher , Kompani Farzad 
Published: January 2023

AbstractIntroductionCentral nervous system cancers (CNS cancers) impose a significant burden upon healthcare systems worldwide. Currently, the lack of a comprehensive study to assess various epidemiological indexes of CNS cancers on national and subnational scales in Iran can hamper healthcare planning and resource allocation in this regard. This study aims to fill this gap by providing estimates of CNS cancer epidemiological measures on national and subnational levels in Iran from 1990 to 2019.Materials and MethodsThis study is a part of Global Burden of Disease (GBD) 2019 that contains epidemiological measures including prevalence, incidence, mortality, Disability‐Adjusted Life Years (DALYs), Years Lived with Disability (YLDs), and Years of Life Lost (YLLs) of CNS cancers. Age standardization was utilized for comparing different provinces.ResultsIn 2019, 5811 (95% Uncertainty Interval: 2942–7046) national new cases and 3494 (1751–4173) deaths due to CNS cancers were reported. National age‐standardized incidence (ASIR), deaths (ASDR), and DALYs rates were 7.3 (3.7–8.8), 4.6 (2.3–5.5), and 156.4 (82.0–187.0) per 100,000 in 2019, respectively. Subnational results revealed that ASDR and ASIR have increased in the past 30 years in all provinces. Although incidence rates have increased in all age groups and genders since 1990, death rates have remained the same for most age groups and genders except for young patients aged under 15, where a decrease in mortality and YLLs can be observed.ConclusionThe incidence, deaths, and DALYs of CNS cancers increased at national and subnational levels. These findings should be considered for planning and resource allocation.
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β‐catenin signaling pathway
Authors: Zhu Jinhong , Cao Kui , Zhang Ping , Ma Jianqun 
Published: January 2023

AbstractLung cancer poses severe threats to human health. It is indispensable to discover more druggable molecular targets. We identified a novel dysregulated long non‐coding RNA (lncRNA), LINC00669, in lung adenocarcinoma (LUAD) by analyzing the TCGA and GEO databases. Pan‐cancer analysis indicated significantly upregulated LINC00669 across 33 cancer types. GSEA revealed a tight association of LINC00669 with the cell cycle. We next attempted to improve the prognostic accuracy of this lncRNA by establishing a risk signature in reliance on cell cycle genes associated with LINC00669. The resulting risk score combined with LINC00669 and stage showed an AUC of 0.746. The risk score significantly stratified LUAD patients into low‐ and high‐risk subgroups, independently predicting prognosis. Its performance was verified by nomogram (C‐index = 0.736) and decision curve analysis. Gene set variation analysis disclosed the two groups' molecular characteristics. We also evaluated the tumor immune microenvironment by dissecting 28 infiltrated immune cells, 47 immune checkpoint gene expressions, and immunophenoscore within the two subgroups. Furthermore, the risk signature could predict sensitivity to immune checkpoint inhibitors and other anticancer therapies. Eventually, in vitro and in vivo experiments were conducted to validate LINC00669's function using qRT‐PCR, CCK8, flow cytometry, western blot, and immunofluorescence staining. The gain‐ and loss‐of‐function study substantiated LINC00669's oncogenic effects, which stimulated non‐small cell lung cancer cell proliferation but reduced apoptosis via activating the Wnt/β‐catenin pathway. Its oncogenic potentials were validated in the xenograft mouse model. Overall, we identified a novel oncogenic large intergenic non‐coding RNA (lincRNA), LINC00669. The resulting signature may facilitate predicting prognosis and therapy responses in LUAD.
Two New Compounds Isolated from the Leaves of Ohwia caudata and Their Neuroprotective Effect against LPS‐Induced BV2 Cells
Authors: Jin Chengwu , Chen Liang , Kuang Zhulingzhi , Sun Yiwei , Meng Dali 
Published: January 2023

AbstractFrom the dried leaves of Ohwia caudata, two new compounds, namely (4E)‐(4‐hydroxyphenyl)‐3‐butenoic acid butyl ester (1), and 4‐benzyl‐1,3‐phenylenedicarbamic acid methyl ester (2), together with five known compounds, were isolated and identified. The structures of compounds 1 and 2 were established using 1D‐NMR, 2D‐NMR and HR‐ESI‐MS spectral analysis. Previous studies on O. caudata had been reported to protect against Alzheimer's disease, two new compounds were evaluated for their neuroprotective effect against lipopolysaccharide‐induced BV2 microglia cells. The result indicated two compounds showed well anti‐neuroinflammatory activity at 12.5 μM.
Anti‐biofilm Activity of Human Milk Oligosaccharides in Clinical Strains of Streptococcus agalactiae with Diverse Capsular and Sequence Types
Authors: Moore Rebecca E. , Spicer Sabrina K. , Talbert Julie A. , Manning Shannon D. , Townsend Steven D. , Gaddy Jennifer A. 
Published: January 2023

AbstractGroup B Streptococcus (GBS) is an encapsulated Gram‐positive bacterial pathogen that causes severe perinatal infections. Human milk oligosaccharides (HMOs) are short‐chain sugars that have recently been shown to possess antimicrobial and anti‐biofilm activity against a variety of bacterial pathogens, including GBS. We have expanded these studies to demonstrate that HMOs can inhibit and dismantle biofilm in both invasive and colonizing strains of GBS. A cohort of 30 diverse strains of GBS were analyzed for susceptibility to HMO‐dependent biofilm inhibition or destruction. HMOs were significantly effective at inhibiting biofilm in capsular‐type‐ and sequence‐type‐specific fashion, with significant efficacy in CpsIb, CpsII, CpsIII, CpsV, and CpsVI strains as well as ST‐1, ST‐12, ST‐19, and ST‐23 strains. Interestingly, CpsIa as well as ST‐7 and ST‐17 were not susceptible to the anti‐biofilm activity of HMOs, underscoring the strain‐specific effects of these important antimicrobial molecules against the perinatal pathogen Streptococcus agalactiae.