bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oleic acid‐induced interleukin‐36γ: A possible link between facial skin redness and sebum
Authors: Kawamoto Akane , Kuwano Tetsuya , Watarai Etsuko , Igarashi Takanori , Katayama Yasushi , Kushida Ken , Nakamura Shun , Murase Takatoshi , Yoshida Hiroyuki , Ishikawa Junko 
Published: March 2023

AbstractBackgroundRedness of the facial skin is an important cosmetic concern. Although qualitative and quantitative modifications of sebum on the skin surface are major pathogenic factors of chronic inflammatory skin conditions, the relationship between skin redness, sebum, and mild inflammation on the cheeks of healthy subjects remains elusive.AimsWe aimed to explore the correlation between cheek redness and sebum and inflammatory cytokines in the stratum corneum (SC) of healthy subjects. We also examined the effects of representative sebum lipids on the gene expression of inflammatory cytokines in cultured keratinocytes.Patients/MethodsThis study included 198 healthy participants. Skin sebum was analyzed using flow injection analysis, and skin redness was assessed using a spectrophotometer. Inflammatory cytokines in tape‐stripped SC were measured using enzyme‐linked immunosorbent assay.ResultsCheek redness parameters positively correlated with the amount of skin sebum and the proportion of monounsaturated free fatty acids (C16:1 and C18:1) in the sebum. They also positively correlated with the interleukin (IL)‐36γ/IL‐37 ratio in the SC. Among the representative sebum lipids examined, oleic acid (C18:1, cis‐9) dose‐ and time‐dependently regulated the mRNA expression of IL‐36γ and IL‐37 in cultured keratinocytes, and this effect was attenuated by the N‐methyl‐D‐aspartate (NMDA)‐type glutamate receptor antagonist, MK801.ConclusionsSkin surface sebum may be related to cheek redness in healthy subjects, and oleic acid‐induced IL‐36γ through NMDA‐type glutamate receptors may be a link between them. Our study provides a possible skincare strategy for mitigating unfavorable increase in skin redness by targeting the facial skin sebum, particularly oleic acid.
Engaging new partners in human papillomavirus (HPV) vaccine promotion: Considerations for training private practice dental professionals in HPV vaccine promotion
Authors: Askelson Natoshia , Ryan Grace , McKernan Susan , Scherer Aaron , Daly Eliza , Avdic Lejla 
Published: March 2023

AbstractObjectivesWith rates of the human papillomavirus (HPV) vaccination remaining low and rates of oropharyngeal cancer rising, engaging new partners to promote vaccination is necessary. We aimed to identify dental hygienists' and dentists' knowledge about HPV, the HPV vaccine, and preferences for continuing education.MethodsThis mixed‐methods study recruited dental hygienists and dentists working in private practice in Iowa to participate in a mailed cross‐sectional survey (dental hygienists) and qualitative telephone interviews (dental hygienists and dentists). Survey and interview topics included existing knowledge about HPV vaccination, HPV vaccination promotion efforts, barriers to HPV vaccine promotion, and preferences for continuing education (CE).ResultsWe received 470 surveys from dental hygienists (response rate = 22.6%) and interviewed 19 dental hygienists and 20 dentists. Vaccine efficacy and safety, along with communication strategies, were key topics of interest for CE. Dental hygienists' most commonly identified barriers were lack of knowledge (67%) and low comfort levels (42%).ConclusionsKnowledge was identified as a key barrier to providing a strong recommendation for HPV vaccination and convenience was the most important factor to consider for any future CE. Our team is in the process of designing a CE course based on this information to help dental professionals effectively engage in HPV vaccine promotion in their practices.
Cost‐effectiveness and economic investment to eliminate chronic hepatitis C in Mexico
Authors: Mooneyhan Ellen , De la Torre Rosas Alethse , Serrano Daniel Bernal , Gamkrelidze Ivane , Sanchez Maria Jesus , Kershenobich David , Sereno Leandro , Razavi Homie 
Published: March 2023

AbstractIn July 2020, the Mexican Government initiated the National Program for Elimination of Hepatitis C (HCV) under a procurement agreement, securing universal, free access to HCV screening, diagnosis and treatment for 2020–2022. This analysis quantifies the clinical and economic burden of HCV (MXN) under a continuation (or end) to the agreement. A modelling and Delphi approach was used to evaluate the disease burden (2020–2030) and economic impact (2020–2035) of the Historical Base compared to Elimination, assuming the agreement continues (Elimination—Agreement to 2035) or terminates (Elimination—Agreement to 2022). We estimated cumulative costs and the per‐patient treatment expenditure needed to achieve net‐zero cost (the difference in cumulative costs between the scenario and the base). Elimination is defined as a 90% reduction in new infections, 90% diagnosis coverage, 80% treatment coverage and 65% reduction in mortality by 2030. A viraemic prevalence of 0.55% (0.50–0.60) was estimated on 1st January 2021, corresponding to 745,000 (95% CI 677,000–812,000) viraemic infections in Mexico. The Elimination—Agreement to 2035 would achieve net‐zero cost by 2023 and accrue 31.2 billion in cumulative costs. Cumulative costs under the Elimination—Agreement to 2022 are estimated at 74.2 billion. Under Elimination—Agreement to 2022, the per‐patient treatment price must decrease to 11,000 to achieve net‐zero cost by 2035. The Mexican Government could extend the agreement through 2035 or reduce the cost of HCV treatment to 11,000 to achieve HCV elimination at net‐zero cost.
Comparison of acknowledged hepatocellular carcinoma risk scores in high‐risk hepatitis C patients with sustained virological response
Authors: Qiu Lixia , Xu Shanshan , Qiu Yundong , Liu Yali , Zhang Jing 
Published: March 2023

AbstractHepatitis C patients with advanced fibrosis or cirrhosis are at high risk of developing hepatocellular carcinoma (HCC) even after sustained virological response (SVR). Several HCC risk scores have been developed but which one is most suitable for this population is unclear. In this study, we compared the prediction ability of the aMAP model, THRI model, PAGE‐B model and Models of HCV in a prospective hepatitis C cohort in order to propose better model(s) to clinical practice. Adult hepatitis C patients with baseline advanced fibrosis (141 cases), compensated cirrhosis (330 cases) and decompensated cirrhosis (80 cases) were included and followed up every 6 months for about 7 years or until HCC development. Demographic data, medical history and laboratory results were recorded. HCCs were diagnosed by radiography, AFP or liver histology. The median follow‐up period was 69.93(60.99–74.93) months, during which 53 (9.62%) patients developed HCC. The areas under the receiver operating characteristic curve of aMAP, THRI, PAGE‐B and Models of HCV scores were 0.74, 0.72, 0.70 and 0.63 respectively. The predictive power of the aMAP model score was comparable to that of THRI, PAGE‐Band higher than that of Models of HCV (p < 0.05). Dividing patients into non‐high‐risk and high‐risk groups, the cumulative incidence rates of HCC based on aMAP, THRI, PAGE‐B and Models of HCV was 5.57% vs. 24.17%, 1.10% vs. 13.90%, 5.80% vs. 15.90% and 6.41% vs. 13.81% (all p < 0.05). The AUC of the four models were all below 0.7 in male while all were higher than 0.7 in female. The performance of all the models was not influenced by fibrosis stage. aMAP, THRI model and PAGE‐B model were all performed well while THRI model and PAGE‐B model were easier to calculate. There was no need to select score according to fibrosis stage but should be caution when explain the results in male patients.
Prospective evaluation of the efficacy of inhaled steroids administered via the AeroDawg spacing chamber in management of dogs with chronic cough
Authors: Chan Jennifer C. , Johnson Lynelle R. 
Published: March 2023

AbstractBackgroundGlucocorticoids are frequently required for management of cough because of inflammatory airway disease (IAD) and airway collapse (AWC).Objectives/HypothesisTo determine the efficacy and feasibility of inhaled administration of corticosteroids in controlling cough in dogs with noninfectious airway disease.AnimalsThirty‐six client‐owned dogs.MethodsDogs were prospectively recruited for this placebo‐controlled cross‐over study. Inflammatory airway disease was diagnosed through bronchoalveolar lavage cytology. Airway collapse was diagnosed through bronchoscopy, or if dogs were unsuitable anesthetic candidates, by crackles on auscultation, radiographic changes in airway diameter, or fluoroscopy. Dogs were randomly assigned to receive placebo or fluticasone propionate for the first 2 weeks of the trial then crossed over to fluticasone. A quality of life (QOL) survey (best score 0, worst score 85) was completed at 0 and 6 weeks. A visual‐analog cough survey was submitted at 0, 2, 4, and 6 weeks to assess cough, feasibility, and adverse effects of treatment.ResultsFor 32 dogs, QOL score at study end (mean 11.3 ± 9.7) was significantly lower (P < .0001) compared to entry (mean 28.1 ± 14.1), with a median change of 69% in QOL score, indicating improved quality of life. Cough frequency, duration, and severity were significantly (P < .0001) decreased at study end. Feasibility of aerosolized delivery improved with continued use (P = .05) with only 1 dog unable to accept inhaled medication.Conclusion and Clinical ImportanceThis study supports the utility of fluticasone propionate by inhalation in management of cough in dogs with IAD and AWC.
Oral cancers preceded by proliferative verrucous leukoplakia exhibit distinctive molecular features
Authors: Herreros‐Pomares Alejandro , Hervás David , Bagan‐Debon Leticia , Proaño Alex , Garcia Diana , Sandoval Juan , Bagan Jose 
Published: March 2023

AbstractObjectiveProliferative verrucous leukoplakia (PVL) has high rates of malignant transformation into oral squamous cell carcinoma (OSCC), but the clinical and evolutionary pattern of OSCC from PVL (PVL‐OSCC) is more favorable than that of OSCC not preceded by PVL (OSCC). Here, we aimed to explore the pathophysiologic differences between PVL‐OSCC and OSCC through transcriptomic and DNA methylation analyses.Materials and methodsIn this case‐control study, oral biopsies from 8 PVL‐OSCC and 10 OSCC patients were obtained for global sequencing using RNAseq and a genome‐wide DNA methylation analysis via the Infinium EPIC Platform (graphical abstract).ResultsOne hundred and thirty‐three differentially expressed genes (DEGs) were detected, 94 of them upregulated in OSCC. Most of these genes were previously described in cancer and associated with prognosis. The integrative analysis revealed 26 DEGs, corresponding to 37 CpGs, whose promoters were regulated by DNA methylation. Twenty‐nine of the CpGs were found as hypermethylated in PVL‐OSCC. Only 5 of the genes that were aberrantly methylated and differentially expressed were upregulated in PVL‐OSCC patients, whereas 21 were underexpressed.ConclusionsPVL‐OSCC patients presented lower expression of cancer‐related genes. Hypermethylation of the promoter region of many genes was also noticed, indicating that DNA methylation could be a regulatory mechanism.
Salt Tolerant Gene 1 contributes to salt tolerance by maintaining photosystem II activity in maize
Authors: Mei Xiupeng , Zhao Zikun , Bai Yang , Yang Qiuyue , Gan Yuling , Wang Wenqin , Li Chaofeng , Wang Jiuguang , Cai Yilin 
Published: March 2023

AbstractSalt stress is a major environmental factor limiting crop growth and productivity. Here, we show that Salt‐Tolerant Gene 1 (ZmSTG1) contributes to salt tolerance by maintaining photosystem activity in maize. ZmSTG1 encodes an endoplasmic reticulum localized protein and retrotransposon insertion in the promoter region causes differential expression levels in maize inbred lines. Overexpression of ZmSTG1 improved plant growth vigor, and knockout of ZmSTG1 weakened plant growth under normal and salt stress conditions. Transcriptome and metabolome analyses indicated that ZmSTG1 might regulate the expression of lipid trafficking‐related genes dependent on the abscisic acid (ABA) signaling pathway, thereby increasing the galactolipids and phospholipid concentrations in the photosynthetic membrane under salt stress. Chlorophyll fluorescence parameters showed that the knockout of ZmSTG1 led to significant impairment of plant photosystem II (PSII) activity under normal and salt stress conditions, whereas overexpression of ZmSTG1 dramatically improved plant PSII activity under salt stress conditions. We also demonstrated that the application of the salt‐tolerant locus could enhance salt tolerance in hybrid maize plants. Taken together, we propose that ZmSTG1 may modulate the lipid composition in the photosynthetic membrane by affecting the expression of lipid trafficking‐related genes to maintain the photosynthetic activity of plants under salt stress.
Forgiveness among Ghanaian children and early adolescents in the context of peer‐to‐peer dyads
Authors: Komesuor Joyce , Nsamenang Sheri A. , Salifu Yendork Joana , Boadu Selina Owusu , Osei‐Tutu Annabella , Worthington Everett L. 
Published: March 2023

AbstractHow children experience forgiveness within peer relationships is unknown among children in West Africa. In this study, we sought to understand the contributing factors and influences of forgiveness among children in Ghana for peer‐to‐peer offenses. We conducted a qualitative study on 25 participants (between the ages of 12 and 15 years) in Accra, Ghana. Thematic analysis was utilized to identify themes from semi‐structured interview transcripts. Unique themes centered around the perception that forgiveness ensures relationship continuation, and that a major source of learning about forgiveness is via a religious institution. Despite a common theme that an offense undermines trust in a relationship, most participants perceived that forgiveness was the preferred option for handling the offense. Results suggest that early adolescents can benefit by learning the skill of forgiveness.
Impact of bronchoscopic lung volume reduction with endobronchial valves on dynamic hyperinflation: Results from the PIERCE study
Authors: Fumat Romane , Dupuis Marion , Mallah Siham , Heluain Valentin , Favard Florent , Simonneau Yannick , Dusselier Matthieu , Barthes Romain , Pontier Sandrine , Collot Samia , Plat Gavin , Egenod Thomas , Guibert Nicolas 
Published: March 2023

AbstractBackground and ObjectiveDynamic hyperinflation (DH) is a major marker of exertional dyspnoea in severe emphysema. We hypothesized that bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) decreases DH.MethodsIn this prospective bi‐centre study from both Toulouse and Limoges Hospitals, we assessed DH during an incremental cycle ergometry before and 3 months after EBVs treatment. The primary objective was to observe the change in inspiratory capacity (IC) at isotime. Target lobe volume reduction (TLVR) and changes in residual volume (RV), forced expiratory volume in one‐second (FEV1), mMRC, 6 minutes walking distance (6MWD), BODE and other dynamic measures like tele‐expiratory volume (EELV) were also analysed.ResultsThirty‐nine patients were included, of whom thirty‐eight presented DH. IC and EELV at isotime significantly improved (+214 mL, p = 0.004; −713 mL, p ˂ 0.001, respectively). Mean changes were +177 mL for FEV1 (+19%, p < 0.001), −600 mL for RV (p < 0.0001), +33 m for 6MWD (p < 0.0001), respectively. Patients who responded on RV (>430 mL decrease) and FEV1 (>12% gain) had better improvements compared to non‐responders (+368 mL vs. +2 mL; +398 mL vs. −40 mL IC isotime, respectively). On the opposite, in patients who responded on DH (>200 mL IC isotime increase), changes in TLV (−1216 mL vs. −576 mL), FEV1 (+261 mL vs. +101 mL), FVC (+496 mL vs. +128 mL) and RV (−805 mL vs. −418 mL) were greater compared to non‐responders.ConclusionsDH decreases after EBVs treatment, and this improvement is correlated with static changes.
Swedish parents' satisfaction and experience of facilitators and barriers with Family Check‐up: A mixed methods study
Authors: Lundgren Julie S. , Ryding Jennie , Ghaderi Ata , Bernhardsson Susanne 
Published: March 2023

Family Check‐up (FCU) was introduced in Sweden more than a decade ago. Little is known about what parents experience as FCU's key mechanisms leading to changes in parenting. The aim of this study was to investigate Swedish parents' satisfaction with FCU, and their experiences of facilitators and barriers for making changes in their parenting. A mixed methods approach was employed using a parent satisfaction questionnaire (n = 77) and focus groups (n = 15). General satisfaction with FCU was adequate, with an average rating of 4 on a five‐point scale (range 3.1–4.6). The analysis of quantitative and qualitative data resulted in eight themes representing facilitators and four themes representing barriers, organized into three categories: (1) access and engagement; (2) therapeutic process; and (3) program components. Ease of access to FCU facilitated initial engagement. Individual tailoring and access to FCU during different phases of change facilitated sustained engagement and change. Therapeutic process facilitators were a meaningful, supportive relationship with the provider, psychological benefits for parents and benefits for the whole family. Program components that facilitated change in parenting were new learning of parenting strategies and use of helpful techniques such as videotaping and home practice. Negative experiences with service systems prior to starting FCU, parent psychological barriers, and parent‐provider mismatch were described as potential barriers. Some parents desired other program formats that were not offered, and some felt that new learning was insufficient to improve child behavior. Understanding the parent perspective can contribute to successful future work with implementing FCU.
Kriging-Based Surrogate Controller for Robust Control of a Flexible Rotor Supported by Active Magnetic Bearings
Authors: De Oliveira Marcus V. F. , Sicchieri Leonardo C. , De Piemonte Dourado Arinan , Cavallini Aldemir Ap. , Steffen Valder 
Published: March 2023

Abstract
Vibration control in supercritical rotors is a challenging task due to the underlying complex dynamics that high-speed machinery undergoes. When taking into account both structural (e.g., structural integrity and material properties) and operational (e.g., rotational speed variation and environmental effects) uncertainties that can plague such systems, the task of designing and implementing a robust and reliable control system becomes increasingly daunting. In this contribution, a Kriging modeling approach is used to derive a representative surrogate-based controller applied to a flexible rotor supported by active magnetic bearings. The surrogate controller is formulated by considering the relationship between the shaft position and actuator current. This means that after proper training, the surrogate control takes the rotor position (proximity sensor readings) as input, and the output corresponds to the current levels for the actuators to control the system vibration amplitudes. Experimental tests considering a test rig composed of a flexible rotor supported by two active magnetic bearings were used to validate the proposed approach for different operational scenarios, namely, steady-state, run-up, and transient-state. In this case, the surrogate model was trained considering the shaft positions and the corresponding control currents measured with the rotor operating close to its first bending critical speed. The obtained results illustrate how the Kriging-based surrogate controller can reliably maintain acceptable vibration levels, even when exposed to unexpected constant rotation speeds and other operating conditions not manifested in previous sample sets.
The life and death of a subglacial lake in West Antarctica
Authors: Siegfried M.R. , Venturelli R.A. , Patterson M.O. , Arnuk W. , Campbell T.D. , Gustafson C.D. , Michaud A.B. , Galton-Fenzi B.K. , Hausner M.B. , Holzschuh S.N. , Huber B. , Mankoff K.D. , Schroeder D.M. , Summers P.T. , Tyler S. , Carter S.P. , Fricker H.A. , Harwood D.M. , Leventer A. , Rosenheim B.E. , Skidmore M.L. , Priscu J.C. ,   the SALSA Science Team
Published: March 2023

Abstract
Over the past 50 years, the discovery and initial investigation of subglacial lakes in Antarctica have highlighted the paleoglaciological information that may be recorded in sediments at their beds. In December 2018, we accessed Mercer Subglacial Lake, West Antarctica, and recovered the first in situ subglacial lake-sediment record—120 mm of finely laminated mud. We combined geophysical observations, image analysis, and quantitative stratigraphy techniques to estimate long-term mean lake sedimentation rates (SRs) between 0.49 ± 0.12 mm a–1 and 2.3 ± 0.2 mm a–1, with a most likely SR of 0.68 ± 0.08 mm a–1. These estimates suggest that this lake formed between 53 and 260 a before core recovery (BCR), with a most likely age of 180 ± 20 a BCR—coincident with the stagnation of the nearby Kamb Ice Stream. Our work demonstrates that interconnected subglacial lake systems are fundamentally linked to larger-scale ice dynamics and highlights that subglacial sediment archives contain powerful, century-scale records of ice history and provide a modern process-based analogue for interpreting paleo–subglacial lake facies.
Impact of tumour volume and treatment delay on the outcome after linear accelerator-based fractionated stereotactic radiosurgery of uveal melanoma
Authors: Sreenivasa Shanthala , Wösle Markus , Gager Yann , Vordermark Dirk , Grajewski Luise , Krause Lothar , Ciernik I. Frank 
Published: March 2023

Background/aimsPrimary radiation therapy is used to treat malignant uveal melanoma (UM). We report our single-centre experience with fractionated radiosurgery (fSRS) with a linear accelerator (LINAC) after specific adaptation for small target volumes with HybridArc.MethodsFrom October 2014 to January 2020, 101 patients referred to Dessau City Hospital with unilateral UM underwent fSRS with 50 Gy given in five fractions on five consecutive days. Primary endpoints were local tumour control, globe preservation, metastasis and death. Potential prognostic features were analysed. Kaplan-Meier analysis, Cox proportional hazards model and linear models were used for calculations.ResultsThe median baseline tumour diameter was 10.0 mm (range, 3.0–20.0 mm), median tumour thickness 5.0 mm (range, 0.9–15.5 mm) and median gross tumour volume (GTV) 0.4 cm³ (range, 0.2–2.6 cm³). After a median follow-up of 32.0 months (range, 2.5–76.0 months), 7 patients (6.9%) underwent enucleation: 4 (4.0%) due to local recurrence and 3 (3.0%) due to radiation toxicities, and 6 patients (5.9%) revealed tumour persistence with a GTV exceeding 1.0 cm³. Of 20 patients (19.8%) who died, 8 (7.9%) were tumour-related deaths. Twelve patients (11.9%) suffered from distant metastasis. GTV showed an impact on all endpoints, and treatment delay was associated with reduced odds of eye preservation.ConclusionLINAC-based fSRS with static conformal beams combined with dynamic conformal arcs and discrete intensity-modulated radiotherapy results in a high tumour control rate. The tumour volume is the most robust physical prognostic marker for local control and disease progression. Avoiding treatment delay improves outcomes.