bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone Marrow Mesenchymal Stem Cell‐Derived Dermcidin‐Containing Migrasomes enhance LC3‐Associated Phagocytosis of Pulmonary Macrophages and Protect against Post‐Stroke Pneumonia
Authors: Li Tiemei , Su Xiaotao , Lu Pinglan , Kang Xinmei , Hu Mengyan , Li Chunyi , Wang Shisi , Lu Danli , Shen Shishi , Huang Huipeng , Liu Yuxin , Deng Xiaohui , Cai Wei , Wei Lei , Lu Zhengqi 
Published: May 2023

AbstractPneumonia is one of the leading causes of death in patients with acute ischemic stroke (AIS). Antibiotics fail to improve prognosis of patients with post‐stroke pneumonia, albeit suppressing infection, due to adverse impacts on the immune system. The current study reports that bone marrow mesenchymal stem cells (BM‐MSC) downregulate bacterial load in the lungs of stroke mice models. RNA‐sequencing of the lung from BM‐MSC‐treated stroke models indicates that BM‐MSC modulates pulmonary macrophage activities after cerebral ischemia. Mechanistically, BM‐MSC promotes the bacterial phagocytosis of pulmonary macrophages through releasing migrasomes, which are migration‐dependent extracellular vesicles. With liquid chromatography‐tandem mass spectrometry (LC‐MS/MS), the result shows that BM‐MSC are found to load the antibacterial peptide dermcidin (DCD) in migrasomes upon bacterial stimulation. Besides the antibiotic effect, DCD enhances LC3‐associated phagocytosis (LAP) of macrophages, facilitating their bacterial clearance. The data demonstrate that BM‐MSC is a promising therapeutic candidate against post‐stroke pneumonia, with dual functions of anti‐infection and immunol modulation, which is more than a match for antibiotics treatment.
Do regional labor market conditions matter for temporary work disability duration? A multilevel analysis of workers' compensation claims in five Canadian provinces
Authors: Macpherson Robert A. , Amick Benjamin C. , Collie Alex , Koehoorn Mieke , Smith Peter M. , McLeod Christopher B. 
Published: May 2023

AbstractBackgroundResearch has shown how regionally varying labor market conditions are associated with differences in work disability duration. However, the majority of these studies have not used multilevel models to appropriately account for the hierarchical clustering of individuals nested within contextual units (e.g., regions). Studies that have used multilevel models have focused on privately insured workers or on disability not specifically caused by work‐related injury or illness.MethodsUsing claims data from five Canadian provincial workers' compensation systems, linear random‐intercept models were used to estimate how much variance in temporary work disability duration ('work disability duration' for brevity) for work‐related injuries and musculoskeletal disorders was due to differences between economic regions, what economic region‐level labor market characteristics were associated with work disability duration, and what characteristics best explained economic region differences in work disability duration.ResultsEconomic region characteristics, such as the unemployment rate and proportion of goods‐producing employment, were independently associated with individual‐level work disability duration. However, economic region variation only accounted for 1.5%–2% of total variation in work disability duration. The majority (71%) of economic region‐level variation was explained by the provincial jurisdiction where the worker lived and was injured. Regional variation tended to be greater for female workers than males.ConclusionsThe findings suggest that while regional labor market conditions matter for work disability duration, system‐level differences in workers' compensation and health care are more important factors influencing work disability duration. Furthermore, while this study includes both temporary and permanent disability claims, the work disability duration measure only captures temporary disability.
Rhesus macaque fetal and placental growth demographics: A resource for laboratory animal researchers
Authors: Roberts Victoria H. J. , Castro Jenna N. , Wessel Brady M. , Conrad Donald F. , Lewis Anne D. , Lo Jamie O. 
Published: May 2023

AbstractRhesus macaques (Macaca mulatta) are amongst the most common nonhuman primate species used in biomedical research. These animals provide a precious resource for translational studies and opportunities to maximize rhesus data use are encouraged. Here we compile data produced from 10 years of investigator‐driven pregnancy studies conducted at the Oregon National Primate Research Center (ONPRC). All pregnancies were generated within the consistent and reproducible protocols of the ONPRC time‐mated breeding program. The data included are from control animals who did not experience in utero perturbations or experimental manipulations. A total of 86 pregnant rhesus macaques were delivered by cesarean section over a range of gestational days (G) 50 to G159 (where term is G165 ± 10 days in the rhesus macaque), with subsequent immediate tissue harvesting following standardized protocols. Fetal and placental growth measures, and all major organ weights are reported. All data are presented relative to gestational age for the entire cohort and in addition, data are stratified by fetal sex. The outcome is a large reference resource for use by laboratory animal researchers in future comparative fetal development studies.
Lung ultrasound: A comparison of image interpretation accuracy between curvilinear and phased array transducers
Authors: Walsh Michael H. , Smyth Leo M. , Desy Janeve R. , Fischer Ernest A. , Goffi Alberto , Li Na , Lee Matthew , St‐Pierre Joëlle , Ma Irene W. Y. 
Published: May 2023

AbstractIntroductionBoth curvilinear and phased array transducers are commonly used to perform lung ultrasound (LUS). This study seeks to compare LUS interpretation accuracy of images obtained using a curvilinear transducer with those obtained using a phased array transducer.MethodsWe invited 166 internists and trainees to interpret 16 LUS images/cineloops of eight patients in an online survey: eight curvilinear and eight phased array, performed on the same lung location. Images depicted normal lung, pneumothorax, pleural irregularities, consolidation/hepatisation, pleural effusions and B‐lines. Primary outcome for each participant is the difference in image interpretation accuracy scores between the two transducers.ResultsA total of 112 (67%) participants completed the survey. The mean paired accuracy score difference between the curvilinear and phased array images was 3.0% (95% CI: 0.6 to 5.4%, P = 0.015). For novices, scores were higher on curvilinear images (mean difference: 5.4%, 95% CI: 0.9 to 9.9%, P = 0.020). For non‐novices, there were no differences between the two transducers (mean difference: 1.4%, 95% CI: −1.1 to 3.9%, P = 0.263). For pleural‐based findings, the mean of the paired differences between transducers was higher in the novice group (estimated mean difference‐in‐differences: 9.5%, 95% CI: 0.6 to 18.4%; P = 0.036). No difference in mean accuracies was noted between novices and non‐novices for non‐pleural‐based pathologies (estimated mean difference‐in‐differences: 0.6%, 95% CI to 5.4–6.6%; P = 0.837).ConclusionsLung ultrasound images obtained using the curvilinear transducer are associated with higher interpretation accuracy than the phased array transducer. This is especially true for novices interpreting pleural‐based pathologies.
The prevalence and anatomy of the pyramidal lobe of the thyroid gland: A meta‐analysis with implications for thyroid surgery
Authors: Ostrowski Patryk , Bonczar Michał , Iwanaga Joe , Michalczak Mateusz , Dziedzic Martyna , del Carmen Yika Alicia , Gil Anna , Sporek Mateusz , Szczepanek Elżbieta , Niemczyk Kazimierz , Walocha Jerzy , Koziej Mateusz 
Published: May 2023

AbstractThe pyramidal lobe (PL), also known as the third lobe of the thyroid gland or lobe of Lalouette is an embryological remnant of the caudal end of the thyroglossal tract. The following meta‐analysis aims to provide a detailed analysis of the anatomical variations of the PL using the available data in the literature. Major online medical databases such as PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched in order to find all studies considering the prevalence and anatomy of the PL of the thyroid gland. Finally, a total of 24 studies that met the required criteria and contained complete and relevant data were included in the present meta‐analysis. The pooled prevalence of the PL was found to be 42.82% (95% CI: 35.90%–49.89%). An analysis showed that the mean length was 23.09 mm (SE: 0.56). The mean width was found to be 10.59 mm (SE: 0.77). The pooled prevalence of the PL originating from the left lobe (LL) was established at 40.10% (95% CI: 28.83%–51.92%). In conclusion, we believe that this is the most accurate and up‐to‐date study regarding the complete surgical anatomy of the PL. The PL was prevalent in 42.82% of the cases, being slightly more prevalent in males (40.35%) than females (37.43%). The mean length and width of the PL were 23.09 mm and 10.59 mm, respectively. Our results should be taken into consideration when performing procedures on the thyroid gland, such as thyroidectomies. The presence of the PL can affect the completeness of this procedure and lead to postoperative complications.
The anatomy of the atrioventricular nodal artery: A meta‐analysis with implications for cardiothoracic surgery and ablation procedures
Authors: Kuniewicz Marcin , Ostrowski Patryk , Bonczar Michał , Kwiecińska Maria , Możdżeń Kamil , Murawska Agnieszka , Dziedzic Martyna , Żytkowski Andrzej , Goncerz Grzegorz , Walocha Jerzy , Koziej Mateusz 
Published: May 2023

AbstractThe objective of the present meta‐analysis was to evaluate recent and applicable data regarding the location and variation of the atrioventricular nodal artery (AVNA) in relation to adjacent structures. In order to minimize postoperative risks and maintain physiological anastomosis for proper cardiac function, understanding such possible variations of vascularization of the AV node is of immense importance prior to cardiothoracic surgery as well as ablations. In order to perform this meta‐analysis, a systematic search was conducted in which all articles regarding, or at least mentioning, the anatomy of the AVNA was searched. In general, the results were based on 3919 patients. AVNA was found to originate only from the RCA in 82.41% (95% CI: 79.46%–85.18%). The pooled prevalence of AVNA originating only from LCA was found to be 15.25% (95% CI: 12.71%–17.97%). The mean length of AVNA was found to be 22.64 mm (SE = 1.60). The mean maximal diameter of AVNA at its origin was found to be 1.40 mm (SE = 0.14). In conclusion, we believe that this is the most accurate and up‐to‐date study regarding the highly variable anatomy of the AVNA. The AVNA was found to originate most commonly from the RCA (82.41%). Furthermore, the AVNA was found to most commonly have no (52.46%) or only one branch (33.74%). It is hoped that the results of the present meta‐analysis will be helpful for physicians performing cardiothoracic or ablation procedures.
The usefulness of CanAssist Breast over Ki67 in breast cancer recurrence risk assessment
Authors: Eshwaraiah Mallikarjuna Siraganahalli , Gunda Aparna , Kanakasetty Govind Babu , Bakre Manjiri M. 
Published: May 2023

AbstractBackgroundAssessment of Ki67 by immunohistochemistry (IHC) has limited utility in clinical practice owing to analytical validity issues. According to International Ki67 Working Group (IKWG) guidelines, treatment should be guided by a prognostic test in patients expressing intermediate Ki67 range, >5%–<30%. The objective of the study is to compare the prognostic performance of CanAssist Breast (CAB) with that of Ki67 across various Ki67 prognostic groups.MethodsThe cohort had 1701 patients. Various risk groups were compared for the distant relapse‐free interval (DRFi) derived from Kaplan–Meier survival analysis. As per IKWG, patients are categorized into three risk groups: low‐risk (<5%), intermediate risk (>5%–<30%), and high‐risk (>30%). CAB generates two risk groups, low and high risk based on a predefined cutoff.ResultsIn the total cohort, 76% of the patients were low risk (LR) by CAB as against 46% by Ki67 with a similar DRFi of 94%. In the node‐negative sub‐cohort, 87% were LR by CAB with a DRFi of 97% against 49% by Ki67 with a DRFi of 96%. In subgroups of patients with T1 or N1 or G2 tumors, Ki67‐based risk stratification was not significant while it was significant by CAB. In the intermediate Ki67 (>5%–<30%) category up to 89% (N0 sub‐cohort) were LR by CAB and the percentage of LR patients was 25% (p < 0.0001) higher compared to NPI or mAOL. In the low Ki67 (≤5%) group, up to 19% were segregated as high‐risk by CAB with 86% DRFi suggesting the requirement of chemotherapy in these low Ki67 patients.ConclusionCAB provided superior prognostic information in various Ki67 subgroups, especially in the intermediate Ki67 group.
Association of unmet basic resource needs with frailty and quality of life among older adults with cancer—Results from the CARE registry
Authors: Williams Grant R. , Fowler Mackenzie , Giri Smith , Dai Chen , Harmon Christian , Al‐Obaidi Mustafa , Stephenson Coryn , Bona Kira , Landier Wendy , Bhatia Smita , Wolfson Julie 
Published: May 2023

AbstractBackgroundBasic resource needs related to transportation, housing, food, and medications are important social determinants of health and modifiable indicators of poverty, but their role in modifying the risk of frailty and health‐related quality of life (HRQoL) remains unknown. The goal of our study was to examine the prevalence of unmet basic needs and their association with frailty and HRQoL in a cohort of older adults with cancer.MethodsThe CARE registry prospectively enrolls older adults (≥60 years) with cancer. Assessments of transportation, housing, and material hardship were added to the CARE tool in 8/2020. The 44‐item CARE Frailty Index was used to define frailty, and subdomains of physical and mental HRQoL were assessed using the PROMIS® 10‐global. Multivariable analysis examined the association between unmet needs with frailty and HRQoL subdomains, adjusting for covariates.ResultsThe cohort included 494 participants. Median age of 69 years, 63.6% were male and 20.2% were Non‐Hispanic (NH) Black. Unmet basic needs were reported in 17.8% (transportation 11.5%, housing 2.8%, and material hardship 7.5%). Those with unmet needs were more often NH Black (33.0% vs. 17.8%, p = 0.006) and less educated (<high school: 19.5% vs. 9.7%, p = 0.023). Compared to those without unmet needs, unmet needs were associated with higher odds of frailty (adjusted odds ratio [aOR] 3.3, 95% CI 1.8–5.9), low physical (aOR = 2.1, 95% CI 1.2–3.8) and low mental (aOR = 2.5, 95% CI 1.4–4.4) HRQoL.ConclusionsUnmet basic needs represent a novel exposure that is independently associated with frailty and low HRQoL and warrants the development of targeted interventions.
Components and effectiveness of patient navigation programmes to increase participation to breast, cervical and colorectal cancer screening: A systematic review
Authors: Mosquera Isabel , Todd Adam , Balaj Mirza , Zhang Li , Benitez Majano Sara , Mensah Keitly , Eikemo Terje Andreas , Basu Partha , Carvalho Andre L. 
Published: May 2023

AbstractBackgroundInequalities in cancer incidence and mortality can be partly explained by unequal access to high‐quality health services, including cancer screening. Several interventions have been described to increase access to cancer screening, among them patient navigation (PN), a barrier‐focused intervention. This systematic review aimed to identify the reported components of PN and to assess the effectiveness of PN to promote breast, cervical and colorectal cancer screening.MethodsWe searched Embase, PubMed and Web of Science Core Collection databases. The components of PN programmes were identified, including the types of barriers addressed by navigators. The percentage change in screening participation was calculated.ResultsThe 44 studies included were mainly on colorectal cancer and were conducted in the USA. All described their goals and community characteristics, and the majority reported the setting (97.7%), monitoring and evaluation (97.7%), navigator background and qualifications (81.4%) and training (79.1%). Supervision was only referred to in 16 studies (36.4%). Programmes addressed mainly barriers at the educational (63.6%) and health system level (61.4%), while only 25.0% reported providing social and emotional support. PN increased cancer screening participation when compared with usual care (0.4% to 250.6% higher) and educational interventions (3.3% to 3558.0% higher).ConclusionPatient navigation programmes are effective at increasing participation to breast, cervical and colorectal cancer screening. A standardized reporting of the components of PN programmes would allow their replication and a better measure of their impact. Understanding the local context and needs is essential to design a successful PN programme.
3D motion analysis of kick start motion−Effects of upper limb movements on the body when leaving the platform−
Authors: Hyodo Hiroki , Wada Tadashi 
Published: May 2023

AbstractThe purpose of this study was to clarify the effect of the presence or absence of upper limb movement on the propulsion direction body velocity (TPV) leaving the platform at kick start. The first trial (Standard trial) is a normal kick start, and the second trial (Lower trial) is the same as a normal kick start. The force from the upper limb movement at the time was set so that the start table was not applied, and the start movement calculated the 3D coordinates of the marker attached to the body by 3D movement analysis. As a result, in the movement speed at the time of leaving the platform, the standard trial had a significantly higher value in the propulsion direction and a significantly lower value in the vertical movement speed than the lower trial. In addition, since the standard trial had a significantly lower value in the jumping angle when leaving the platform, the role of the upper limb movement in kick start is to promote by making the jumping angle closer to the horizontal when leaving the platform. It was suggested that it may affect the directional velocity.
Recent advances of cellular stimulation with triboelectric nanogenerators
Authors: Zhou Xingyu , Li Gaocai , Wu Di , Liang Huaizhen , Zhang Weifeng , Zeng Lingli , Zhu Qianqian , Lai Puxiang , Wen Zhen , Yang Cao , Pan Yue 
Published: May 2023

AbstractTriboelectric nanogenerators (TENGs) are new energy collection devices that have the characteristics of high efficiency, low cost, miniaturization capability, and convenient manufacture. TENGs mainly utilize the triboelectric effect to obtain mechanical energy from organisms or the environment, and this mechanical energy is then converted into and output as electrical energy. Bioelectricity is a phenomenon that widely exists in various cellular processes, including cell proliferation, senescence, apoptosis, as well as adjacent cells’ communication and coordination. Therefore, based on these features, TENGs can be applied in organisms to collect energy and output electrical stimulation to act on cells, changing their activities and thereby playing a role in regulating cellular function and interfering with cellular fate, which can further develop into new methods of health care and disease intervention. In this review, we first introduce the working principle of TENGs and their working modes, and then summarize the current research status of cellular function regulation and fate determination stimulated by TENGs, and also analyze their application prospects for changing various processes of cell activity. Finally, we discuss the opportunities and challenges of TENGs in the fields of life science and biomedical engineering, and propose a variety of possibilities for their potential development direction.
Hydrogenated silicene nanosheet functionalized scaffold enables immuno‐bone remodeling
Authors: Lin Zixuan , Chen Zhixin , Chen Yiwei , Yang Nan , Shi Jianlin , Tang Zhongmin , Zhang Changqing , Lin Han , Yin Junhui 
Published: May 2023

AbstractAn ideal implant needs to have the ability to coordinate the foreign body response and tissue regeneration. Here, Hydrogenated‐silicon nanosheets (H‐Si NSs) with favorable biodegradability are integrated and functionalized into a β‐tricalcium phosphate scaffold (H‐Si TCP) for bone defect healing. H‐Si TCP can greatly improve bone regeneration through osteoimmunomodulation‐guided biodegradation in vivo. The spatiotemporal regulation of degradation products replenishes sufficient nutrients step by step for the entire process of bone repair. Extracellular and intracellular reactive oxygen species (ROS) are first downregulated by reaction with H‐Si NSs, followed by marked M2 polarization, remodeling the micro‐environment timely for immune‐bone regeneration. The release of primary reaction products awakened bone marrow mesenchymal stem cells (BMSCs), which are converted into osteoblasts anchored on scaffolds. Subsequently, biomineralization is promoted by the final degradation products. The intrinsic ROS‐responsive, immunoregulatory, and osteo‐promotive capability of 2D H‐Si NSs makes such composite H‐Si TCP scaffold a highly potential alternative for the treatment of critical bone defect.
Effect of walnut peptide‐ZnO nanocomposites on the colon adhesion behavior of Lactobacillus rhamnosus LRa05
Authors: Liang Ming , Wang Min , Zhou Miao , Nie Shiying , Xu Yongzhao , Yang Xinquan , Yuan Erdong , Ren Jiaoyan 
Published: May 2023

AbstractWhen the nanoparticles (NPs) in food contact materials are exposed, they may be ingested with the food matrix, resulting in unknown impacts. Here, the biological response of the nanocomposites of nano zinc oxide (nZnO) and walnut protein‐derived peptides (i.e., PW5, WN5, AE6, and WE7) on the Lactobacillus rhamnosus LRa05 growth and adhesion was studied. In an in vitro mouse intestinal adhesion model, we first spotted that the probiotics LRa05 primarily adhered to and colonized the colonic segment. nZnO effectively inhibited the growth and adhesion properties of LRa05 at high concentrations (≥ 1000 μg/mL). Fortunately, when compared to the individual nZnO, the nZnO‐walnut‐derived peptides nanocomposites significantly increased the growth of LRa05. It was found that the alterations in the adhesion ability of LRa05 after treatment with various substances (nZnO and nanocomposites of nZnO‐walnut peptides) were related to the auto‐aggregating property on the LRa05 surface. These results shed light on the effect of food matrices on the safety of nanomaterials in food, and they may have far‐reaching implications for the use of nanomaterials in the food industry.