bluuebunny/crossref_metadata_2025_split huggingface dataset:
EFEITOS DE INTERVENÇÕES COM EXERCÍCIOS RESPIRATÓRIOS DIAFRAGMÁTICOS NOS SINTOMAS DE ANSIEDADE EM ADOLESCENTES: UMA REVISÃO SISTEMÁTICA
Authors: Wally Hartwig Tiago , Oliveira Karini da Cunha Gicele , Gustavo Bergmann Gabriel 
Published: August 2023

O objetivo desta revisão sistemática foi identificar e sumarizar estudos que analisaram os efeitos de intervenções que utilizaram exercícios respiratórios diafragmáticos sobre os sintomas de ansiedade em adolescentes. O estudo está registrado na plataforma PROSPERO (CRD42022328536) e seguiu a metodologia PRISMA. A busca foi realizada entre os meses de julho e agosto de 2022 nas bases de dados MedLine/PubMed, PsycINFO, CINAHL, SPORTDiscus, EMBASE, Scielo, Web of Science e Scopus. Palavras-chave considerando a população (adolescentes), tipo de intervenção (exercício respiratório diafragmático), desfecho (sintomas de ansiedade) e delineamento do estudo (estudos experimentais e suas sub classificações e estudos quase experimentais) foram combinados utilizando operadores boleanos. A qualidade metodológica foi determinada através da escala PEDro. Dos 123 registros identificados, cinco artigos foram incluídos, totalizando 518 adolescentes, sendo a maioria composta por estudantes escolares (51,1%). 60,0% dos estudos foram realizados na Ásia. A idade média geral foi de 15,9 anos e os instrumentos utilizados para a avaliação dos sintomas de ansiedade foram o STAI (State-Trait Anxiety Inventory), STAIC-S (State-Trait Anxiety Inventory for Children State), GAD-7 (General Anxiety Disorder-7) e a Escala de Autoavaliação de Ansiedade de Zung. As intervenções apresentaram características distintas em relação ao período de aplicação, ao tempo em minutos para a prática, à profundidade na descrição das atividades, e ao contexto para a aplicação. Porém, os estudos incluídos indicaram efeitos positivos de exercícios respiratórios diafragmáticos nos sintomas de ansiedade em adolescentes. Apenas um estudo não encontrou resultados estatisticamente positivos. No entanto, o reduzido número de estudos e algumas fragilidades metodológicas sugerem que a generalização desses achados seja acompanhada com cautela. Por fim, é recomendado que futuros estudos descrevam os protocolos de aplicação dos exercícios respiratórios diafragmáticos detalhadamente e que sejam desenvolvidos com períodos de intervenções maiores.
Features of the Intestinal Microbiota in Patients with Inflammatory Intestinal Diseases
Authors: Лагутина С.Н. , Чижков П.А. , Зуйкова А.А. , Есина Е.Ю. , Добрынина И.С. , Скуратова О.С. , Сыромятников М.Ю. 
Published: August 2023

Введение. Воспалительные заболевания кишечника (ВЗК) занимают лидирующие позиции в структуре заболеваний желудочно-­кишечного тракта (ЖКТ), так как являются прогрессирующей хронической патологией с аутоиммунным типом воспаления. Изменение показателей микробиоты кишечника может определять морфологические изменения на латентном этапе заболевания. Цель исследования. Оценка родо-видового биоразнообразия микробиоты у пациентов с ВЗК. Пациенты и методы. Выполнено секвенирование 16S рРНК микробиоты кишечника у 15 пациентов с подтвержденным язвенным колитом (ЯК) и 20 здоровых лиц, которые являлись контрольной группой. Проведен анализ показателей общего анализа крови и уровня С-реактивного белка (СРБ). Для статистического анализа использовали программы Microsoft Excel и Statistica. Результаты. Среди исследуемых лабораторных показателей у пациентов с ВЗК было отмечено значительное увеличение уровня СРБ, лейкоцитов и нейтрофилов по сравнению с группой контроля. В результате секвенирования кишечной микробиоты у пациентов с ВЗК выявлено снижение нормобиоты, а также увеличение содержания представителей патогенного кластера. Заключение. Выявлено снижение биоразнообразия микробиоты у пациентов с ВЗК по сравнению с группой контроля. Также наблюдалось значимое изменение патогенного кластера и дисбаланс представителей Bacteroidetes и Firmicutes.
Introduction. Inflammatory bowel diseases (IBD) occupy a leading position in the structure of diseases of the gastrointestinal tract (GIT), as they are a progressive chronic pathology with an autoimmune type of inflammation. Changes in the composition of the gut microbiota can determine morphological changes at the latent stage of the disease. Aim of the study. To assess the genus-­species biodiversity of the microbiota in patients with IBD. Patients and methods. 16S rRNA sequencing of the intestinal microbiota was performed in 15 patients with confirmed ulcerative colitis (UC) and 20 healthy controls. The parameters of the full blood count and the serum level of C-reactive protein (CRP) were analyzed. The analysis of the obtained data was carried out using Microsoft Excel and Statistica software. Results. Among the studied laboratory parameters in patients with IBD, there was a significant increase in CRP, leukocyte and neutrophil counts compared to the control group. Sequencing of the gut microbiota showed a decrease in the normobiota, as well as an increase in the representatives of the pathogenic cluster. Conclusion. In the present study, we demonstrated a decrease in the biodiversity of the gut microbiota in patients with IBD compared to the control group, a significant change in the pathogenic cluster, and an imbalance between the representatives of Bacteroidetes and Firmicutes.
Fausto y Goethe: una lectura de Edith Stein
Authors: Reyes-Gacitúa Eva 
Published: August 2023

“Natural y sobrenatural en el Fausto de Goethe” es un breve texto de Edith Stein redactado en vistas al centenario de la muerte del dramaturgo alemán. A modo de conferencia lo presenta en la ciudad de Ludwigshafen, el 26 de junio de 1932 en el Convento de Santo Domingo (Stein, 2002, p. 315). Allí viven las religiosas dominicas de Santa Magdalena de Espira quienes tienen a su cargo un Instituto femenino y una escuela de enseñanza media. El manuscrito original se conserva en 45 hojas y más adelante fue publicado en la revista Zeit und Schule del mismo año...
Retórica subalterna en poemas da recordação e outros movimentos de conceição evaristo, subjetividad que enuncia y expone la diferencia a través de la voz y el cuerpo de las mujeres afrobrasileñas
Authors: Lizana-Miranda Paola 
Published: August 2023

En el presente análisis proponemos una lectura del poemario Poemas da recordação e outros movimentos (2008) de Conceição Evaristo desde una perspectiva de la retórica subalterna, entendiendo lo anterior como la emergencia literaria de otras formas subjetivas. En este sentido afirmamos que en el poemario en análisis la subjetividad de la hablante se construye a través de la voz y el cuerpo femenino, afirmando la diferencia como sustento subjetivo.
Synthesis, characterization, molecular docking, in silico ADME study, and in vitro cytotoxicity evaluation of new pyridine derivatives of nabumetone.
Authors: Bushra K. Jameel  , Ayad Mohammed Rasheed Raauf  , Wassan Abdul Kareem Abbas  
Published: August 2023

New pyridine derivatives of nabumetone containing 2-amino 3-cyano moieties were synthesized and aimed to introduce new EGFR kinase inhibitors through two methods either by synthesis of chalcone derivatives initially (1a-d)
followed by reacting it with malononitrile and ammonium acetate to form (2a-d) or from a one-pot synthesis of all reactants together to synthesis compounds (2a-e). Melting point, and FT-IR spectra were used to characterize all the synthesized compounds and were confirmed by 1H-NMR, and 13C-NMR spectroscopy. The final compounds (2a-e) were investigated in vitro against A549 (lung cancer cell line) and WRL68 (human normal cell line). compounds (2a, 2b, and 2e) produced marked cytotoxic activity with IC50 (24.62, 23.43, and 24.06 μg/ml) respectively, higher than what obtained from erlotinib with IC50 (25 μg/ml) as a reference drug. Measuring the selectivity index (SI) reveals that all the compounds have high selectivity especially compound (2a) being the most selective towards cancerous cells rather than normal cells with SI two folds higher than erlotinib. The molecular docking study reveals good binding to the EGFR kinase that has a good correlation to the MTT Assay results. In silico ADME study exposes that this synthesized series not only have interesting activity but also shows promised pharmacokinetic properties.
1757 Yılında Şam Hac Kafilesi ve Hicaz: Tedbirler ve Olaylar
Authors: GÜLER Mustafa , ÖZASLAN Fatih 
Published: August 2023

Hac, Hicaz ve Arap coğrafyasının en mühim sosyal, dini ve ekonomik olgularından biridir. Zaman ve mekân olarak sınırlandırılması nedeniyle günümüzde olduğu gibi geçmişte de yolculuklar, güvenlik, idare ve menâsikin ifası bölge yöneticilerinin en mühim uğraşlarından olmuştur.
Şam Şehri, Hac kervanlarının sevki, güvenliği ve Mekke ile Medine şehirlerine ulaştırılacak para ve ayni malzemenin ulaştırılması noktasında önemli bir rol oynamıştır. İslam’ın Anadolu, Balkanlar, Kafkasya ve Orta Asya’ya yayılmasından itibaren ise en mühim toplanma ve çöl şartlarına hazırlanma merkezi olmuştur. Şam ve çevresinin Osmanlı hâkimiyetine geçmesinden sonra ise Şam şehri hem yukarıda belirttiğimiz bölgelerden gelen kafilelerin buluşma noktası, hem de Osmanlı sultanını temsilen şehre ulaşan Surre alaylarının, askeri birliklerin ve Hac emirinin harekât merkezi olmuştur. 1517’den başlayan bu süreç 1671’de farklı bir alana evirilmiş, 1708’de Şam valilerinin Hac emiri olmaları güç ve itibarlarını artırmıştır.
Bu çalışmada Osmanlı Arşiv belgeleri, kronikler ve telif çalışmalar temel alınarak miladi 1757 yılında Şam’dan yola çıkan hac kervanının idaresi, gidiş ve dönüş yolunda karşılaştığı güvenlik problemleri ve 1758 yılı haccında alınan önlemler ele alınacaktır. Şam’dan Mekke ve Medine’ye nakledilen nakit para ve eşyanın miktarı ele alınacaktır. Bu yapılırken anılan zaman diliminde Şam’dan Mekke’ye kadar uzanan ana kervan yolunun ahvali, yol civarında yaşayan kabilelerin Hac emiri ve hacılarla ilişkileri detaylı olarak tahlil edilecektir.
Human genome editing in clinical applications: Japanese lay and expert attitudes
Authors: Sawai Tsutomu , Hatta Taichi , Akatsuka Kyoko , Fujita Misao 
Published: August 2023

Background: The world’s first gene-edited babies, reported by the Chinese scientist He Jiankui, prompted an outcry of criticism and concerns worldwide over the use of genome editing for reproductive purposes. Many countries and academic associations opposed to heritable genome editing (HGE) called for public discussion involving various stakeholders. To hold a discussion of this nature and form a consensus concerning HGE, we must understand under what conditions stakeholders consider HGE acceptable and the reasons for which they deem it unacceptable.Methods: Laypeople and researchers were surveyed in May 2019. They were asked about the degree of their acceptance toward somatic genome editing (SGE) and HGE; those who answered “acceptable depending on the purpose” were queried further regarding their acceptance in the contexts of specific clinical purposes.Results: Responses were obtained from 4,424 laypeople and 98 researchers. The percentage of respondents choosing each option in attitudes to HGE was, from largest to smallest: “acceptable depending on purpose” (laypeople 49.3%; researchers 56.1%), “not acceptable for any purpose” (laypeople 45.8%; researchers 40.8%), and “acceptable for any purpose” (laypeople 5.0%; researchers 3.1%). In an additional question for those who answered “acceptable depending on the purpose,” laypeople found the following purposes acceptable: infertility treatment (54.5%), treatment of life-threatening diseases (52.2%), and treatment of debilitating diseases (51.4%). Meanwhile, the degree of acceptance for enhancement purposes was 10.7, 7.9, 6.2, and 5.5% for physical, cognitive, health, and personality enhancements, respectively. In contrast, acceptance among the researchers was 94.5% and 92.7% for the treatment of life-threatening and debilitating diseases, respectively, compared with 69.1% for infertility treatment. Researchers’ acceptance for enhancement purposes was similar to that of the lay participants, with 12.7, 9.1, 10.9, and 5.5% for physical, cognitive, health, and personality enhancement, respectively.Conclusion: In the past, debates regarding the acceptability of human genome editing in clinical applications tend to focus on HGE in many countries. Society will now need to debate the acceptability of both types of human genome editing, HGE and SGE.
Citrullinated and malondialdehyde-acetaldehyde modified fibrinogen activates macrophages and promotes an aggressive synovial fibroblast phenotype in patients with rheumatoid arthritis
Authors: Aripova Nozima , Duryee Michael J. , England Bryant R. , Hunter Carlos D. , Mordeson Jack E. , Ryan Evan M. , Daubach Eric C. , Romberger Debra J. , Thiele Geoffrey M. , Mikuls Ted R. 
Published: August 2023

ObjectivePost-translational protein modifications with malondialdehyde-acetaldehyde (MAA) and citrulline (CIT) are implicated in the pathogenesis of rheumatoid arthritis (RA). Although precise mechanisms have not been elucidated, macrophage-fibroblast interactions have been proposed to play a central role in the development and progression of RA. The purpose of our study was to evaluate the downstream effects of macrophage released soluble mediators, following stimulation with fibrinogen (FIB) modified antigens, on human fibroblast-like synoviocytes (HFLS).MethodsPMA-treated U-937 monocytes (Mϕ) and macrophage-differentiated peripheral blood mononuclear cells (MP) were stimulated with FIB, FIB-MAA, FIB-CIT, or FIB-MAA-CIT. HFLS-RA cells were stimulated directly with FIB antigens or with supernatants (SN) from macrophages (Mϕ-SN or MP-SN) stimulated with FIB antigens. Genes associated with an aggressive HFLS phenotype, extracellular matrix proteins, and activated signaling pathways were evaluated.ResultsHFLS-RA cells treated with Mϕ-SNFIB-CIT and Mϕ-SNFIB-MAA-CIT demonstrated significant increases in mRNA expression of genes associated with an aggressive phenotype at 24-h as compared to direct stimulation with the same antigens. Similar results were obtained using MP-SN. Cellular morphology was altered and protein expression of vimentin (p&lt;0.0001 vs. Mϕ-SNFIB) and type II collagen (p&lt;0.0001) were significantly increased in HFLS-RA cells treated with any of the Mϕ-SN generated following stimulation with modified antigens. Phosphorylation of JNK, Erk1/2, and Akt were increased most substantially in HFLS-RA treated with Mϕ-SNFIB-MAA-CIT (p&lt;0.05 vs Mϕ-SNFIB). These and other data suggested the presence of PDGF-BB in Mϕ-SN. Mϕ-SNFIB-MAA-CIT contained the highest concentration of PDGF-BB (p&lt;0.0001 vs. Mϕ-SNFIB) followed by Mϕ-SNFIB-CIT then Mϕ-SNFIB-MAA. HFLS-RA cells treated with PDGF-BB showed similar cellular morphology to the Mϕ-SN generated following stimulation with modified FIB, as well as the increased expression of vimentin, type II collagen, and the phosphorylation of JNK, Erk1/2 and Akt signaling molecules.ConclusionTogether, these findings support the hypothesis that in response to MAA-modified and/or citrullinated fibrinogen, macrophages release soluble factors including PDGF-BB that induce fibroblast activation and promote an aggressive fibroblast phenotype. These cellular responses were most robust following macrophage activation with dually modified fibrinogen, compared to single modification alone, providing novel insights into the combined role of multiple post-translational protein modifications in the development of RA.
Cost-benefit analysis of ballast water treatment for three major port clusters in China: evaluation of different scenario strategies
Authors: Nie Anwei , Wan Zheng , Shi ZhuangFei , Wang Zhaojun 
Published: August 2023

IntroductionThe expansion of maritime trade has led to the introduction of invasive species into aquatic ecosystems through ballast water discharge. China, being a major player in global trade and manufacturing, has experienced negative impacts on its coastal ecosystems and marine biodiversity.MethodsThis study examines the cost‒benefit trade-offs of ballast water management policies for major port clusters in China and other global ports. This paper evaluates compliance costs for individual vessels and fleets under different policy scenarios and ballast water treatment system (BWTS) installation strategies.ResultsThe onboard BWTS installation strategy appears to be more cost-effective under the existing International Maritime Organization (IMO) policy. However, with stricter global discharge requirements or a substantial increase in BWTS capital and operating costs, strategies based on port location could prove more beneficial due to potential economies of scale. Notably, ships with high ballast water discharge volumes, like bulk carriers, are potentially better equipped to cope with future policy shifts. In the face of stricter regulations in China, projected annual compliance cost increases range from $456 million (cost data based on China) to $1.205 billion (cost data based on US).DiscussionPolicymakers are advised to adopt a comprehensive view of ballast water management policies, taking into account the trade-offs between compliance costs and environmental risks. Other essential factors, such as advancements in BWTS technology, fuel consumption, emissions, and maintenance costs, also demand careful consideration in policy development.
Generative adversarial network-based attenuation correction for 99mTc-TRODAT-1 brain SPECT
Authors: Du Yu , Jiang Han , Lin Ching-Ni , Peng Zhengyu , Sun Jingzhang , Chiu Pai-Yi , Hung Guang-Uei , Mok Greta S. P. 
Published: August 2023

BackgroundAttenuation correction (AC) is an important correction method to improve the quantification accuracy of dopamine transporter (DAT) single photon emission computed tomography (SPECT). Chang's method was developed for AC (Chang-AC) when CT-based AC was not available, assuming uniform attenuation coefficients inside the body contour. This study aims to evaluate Chang-AC and different deep learning (DL)-based AC approaches on 99mTc-TRODAT-1 brain SPECT using clinical patient data on two different scanners.MethodsTwo hundred and sixty patients who underwent 99mTc-TRODAT-1 SPECT/CT scans from two different scanners (scanner A and scanner B) were retrospectively recruited. The ordered-subset expectation-maximization (OS-EM) method reconstructed 120 projections with dual-energy scatter correction, with or without CT-AC. We implemented a 3D conditional generative adversarial network (cGAN) for the indirect deep learning-based attenuation correction (DL-ACμ) and direct deep learning-based attenuation correction (DL-AC) methods, estimating attenuation maps (μ-maps) and attenuation-corrected SPECT images from non-attenuation-corrected (NAC) SPECT, respectively. We further applied cross-scanner training (cross-scanner indirect deep learning-based attenuation correction [cull-ACμ] and cross-scanner direct deep learning-based attenuation correction [call-AC]) and merged the datasets from two scanners for ensemble training (ensemble indirect deep learning-based attenuation correction [eDL-ACμ] and ensemble direct deep learning-based attenuation correction [eDL-AC]). The estimated μ-maps from (c/e)DL-ACμ were then used in reconstruction for AC purposes. Chang's method was also implemented for comparison. Normalized mean square error (NMSE), structural similarity index (SSIM), specific uptake ratio (SUR), and asymmetry index (%ASI) of the striatum were calculated for different AC methods.ResultsThe NMSE for Chang's method, DL-ACμ, DL-AC, cDL-ACμ, cDL-AC, eDL-ACμ, and eDL-AC is 0.0406 ± 0.0445, 0.0059 ± 0.0035, 0.0099 ± 0.0066, 0.0253 ± 0.0102, 0.0369 ± 0.0124, 0.0098 ± 0.0035, and 0.0162 ± 0.0118 for scanner A and 0.0579 ± 0.0146, 0.0055 ± 0.0034, 0.0063 ± 0.0028, 0.0235 ± 0.0085, 0.0349 ± 0.0086, 0.0115 ± 0.0062, and 0.0117 ± 0.0038 for scanner B, respectively. The SUR and %ASI results for DL-ACμ are closer to CT-AC, Followed by DL-AC, eDL-ACμ, cDL-ACμ, cDL-AC, eDL-AC, Chang's method, and NAC.ConclusionAll DL-based AC methods are superior to Chang-AC. DL-ACμ is superior to DL-AC. Scanner-specific training is superior to cross-scanner and ensemble training. DL-based AC methods are feasible and robust for 99mTc-TRODAT-1 brain SPECT.
Heat-stone massage for patients with chronic musculoskeletal pain: a protocol for multicenter randomized controlled trial
Authors: Li Li , Xi Yawei , Wang Ying , Gao Yinqiu , Lv Xiaoying , Liu Shu , Yang Guangjing , Qian Jingjing , Yang Xiaofang , Ayad Nardeen , Zhou Jiayan , Sun Ya Xuan , Liu Jin , Li Jinlin , Chen Guang 
Published: August 2023

IntroductionChronic musculoskeletal pain bothers the quality of life for approximately 1.71 billion people worldwide. Although pharmacological therapies play an important role in controlling chronic pain, overuse of opioids, persistent or recurrent symptoms, and pain-related disability burden still need to be addressed. Heat-stone massage is using the heated stone to stimulate muscles and ligaments followed by massage for relax, which can potentially treat the chronic musculoskeletal pain. To determine the efficacy and safety of heat-stone massage for patients with chronic musculoskeletal pain is needed.Methods and analysisThis multicenter, 2-arm, randomized, positive drug-controlled trial will include a total of 120 patients with chronic musculoskeletal pain. The intervention group will receive a 2 week heat-stone massage, 3 times per week, whereas the control group will receive the flurbiprofen plaster twice per day for 2 weeks. The primary end point is the change in Global Pain Scale from baseline to the end of the 2 week intervention. The secondary outcomes include the pain severity (Numerical Rating Scale), pain acceptance (Chronic Pain Acceptance Questionnaire), self-management (Health Education Impact Questionnaire), self-efficacy (Pain Self-Efficacy Questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), quality of life (Short Form-36). The intention-to-treat dataset will be used for analysis.DiscussionThe pain management remains the research topic that patients always pay close attention to. This will be the first randomized clinical trial to evaluate whether heat-stone massage, a non-pharmacological therapy, is effective in the chronic musculoskeletal pain management. The results will provide evidence for new option of daily practice.Clinical trial registrationWorld Health Organization Chinese Clinical Trial Registry [ChiCTR2200065654; https://www.chictr.org.cn/showproj.html?proj=185403]; International Traditional Medicine Clinical Trial Registry [ITMCTR2022000104; http://itmctr.ccebtcm.org.cn/en-US/Home/ProjectView?pid=51776b6f-77b8-4811-9b5a-a0fec10f2cee].