bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the effects of pregabalin and famotidine with pregabalin and diphenhydramine on postoperative abdominal pain
Authors: Fakhr Masoud Saadat , Chaboki Parnian Motamed , Ashayeri Hemin , Sahranavard Pouria , Mohammadipanah Somayeh , Zamanabadi Mahnaz Narimani 
Published: August 2023

Abstract

Objectives
Pain is one of the most significant problems, and its uncontrolled management can lead to complications such as increased blood pressure, myocardial ischemia, etc. An effective approach to control postoperative pain is preemptive pain management with a combination of drugs prior to surgery. The present study aims to compare the level of postoperative abdominal pain in patients receiving pregabalin and famotidine versus pregabalin and diphenhydramine.

Materials and methods
In this double-blind clinical trial, a total of 34 candidates for abdominal surgery (laparotomy) with ASA physical status classification of 1 or 2 were enrolled from the patients referring to (XXX). They were divided into two groups of 17 (Group A: pregabalin and famotidine, Group B: pregabalin and diphenhydramine). The drugs were administered to the patients 2 h before the surgery. The patients’ pain levels were measured using the Visual Analog Scale (VAS) at the recovery stage after complete consciousness and at 6, 12, and 24 h postoperatively. Additionally, the amount of analgesic consumed within the first 24 h after the surgery was recorded and compared between the two groups.

Results
The average pain intensity score at 6 h postoperatively was (6 ± 0.2) in patients who received pregabalin and diphenhydramine, and (7.1 ± 0.1) in patients who received pregabalin and famotidine (p = 0.002). The average pain intensity score at 12 h postoperatively was (6.1 ± 0.3) in patients who received pregabalin and famotidine, and (5.6 ± 0.2) in patients who received pregabalin and diphenhydramine (p = 0.021). Furthermore, the average pain intensity score at 24 h postoperatively was (5.2 ± 0.2) in patients who received pregabalin and famotidine, and (4.2 ± 0.2) in patients who received pregabalin and diphenhydramine (p = 0.014). The results demonstrated that the pain intensity score decreased in all four measured time intervals in the overall patient population (p < 0.001), and this reduction was significantly different between the two groups (p = 0.002), with the final average pain score being lower in the group receiving pregabalin and diphenhydramine compared to the other group.

Conclusion
The results of this study indicate that the use of drugs such as diphenhydramine and pregabalin as preemptive medications can be effective in controlling postoperative abdominal pain and reducing the consumption of analgesics in patients after abdominal surgery.

Highlights
Root Seeking and Remote Sensing with the Bunun in the Mountains of Taiwan
Authors: Cheng Chieh-fu Jeff 
Published: August 2023

AbstractMany Indigenous groups in Taiwan, including the Bunun, inhabited remote mountainous regions. Beginning in the 1930s, all mountain settlements were relocated to lower-lying areas by the colonial authorities. These groups lost the territories where they used to hunt, practice slash-and-burn agriculture, and carry out other social and cultural practices. Having being separated from their ancestral lands for decades, their knowledge of their former settlements and traditional ways of life is gradually disappearing. In recent years, there is a tendency among the younger generation of Indigenous people to organize and participate in roots-seeking expeditions. As their knowledge about the former settlements is limited, they seek help from the elderly—and archaeologists. Since 2014, I have collaborated with Bunun communities, recording their ancestors’ lands in the Lakulaku River Basin by joining archaeological surveys on roots-seeking trips. During these surveys, I had to learn Bunun values and gain knowledge of the Lakulaku River Basin via the bodily experience of moving through and being in the landscape with its traditional inhabitants. By applying remote-sensing technologies such as airborne lidar in our surveys, our team managed to identify and record settlements that were unfamiliar to the Bunun.
Gaussian fluctuations in the equipartition principle for Wigner matrices
Authors: Cipolloni Giorgio , Erdős László , Henheik Joscha , Kolupaiev Oleksii 
Published: August 2023

Abstract
The total energy of an eigenstate in a composite quantum system tends to be distributed equally among its constituents. We identify the quantum fluctuation around this equipartition principle in the simplest disordered quantum system consisting of linear combinations of Wigner matrices. As our main ingredient, we prove the Eigenstate Thermalisation Hypothesis and Gaussian fluctuation for general quadratic forms of the bulk eigenvectors of Wigner matrices with an arbitrary deformation.
ARISTOPHANES VS PHRYNICHUS IN FROGS
Authors: Lewis Amy S. 
Published: August 2023

AbstractAristophanes’ Frogs was first performed at the Lenaea festival of 405 in competition with Plato's Cleophon and Phrynichus’ Muses. This paper argues that Frogs contains a series of agonistic jokes against Phrynichus, most of which have gone unnoticed because he shares his name with a tragic poet and a politician; Aristophanes plays with the ambiguity of the name Phrynichus to mock his Lenaean rival by comparing him unfavourably with his namesakes. Aristophanes ultimately claims that his comedy is superior to that of Phrynichus because he is more successful than his rival in appropriating and redeploying other comedians’ material.
Problematising entanglement fetishism in IR: On the possibility of being without being in relation
Authors: Torrent Ignasi 
Published: August 2023

Abstract
The following article seeks to question the deterministic tinge behind entanglement fetishism, namely the celebratory, uninhibited, and totalising projection of the world as a relational wholeness. Alongside the rise of Anthropocene debates and the claimed incapacity of post-positivism to account for contemporary socio-natural transformations, the text embarks on two main goals. On the one hand, the article sketches a brief genealogy of processual and relational thinking, with a focus on International Relations (IR) literature. On the other hand, the text seeks to move forward critical engagements with the entangled grand narrative. To this end, the article exposes a problematic ontological assumption often overlooked by both entanglement fetishists and their critics: entanglements are infallibly generative, that is to say, they deterministically precipitate further beings and events. In doing so, the text invites IR scholarship to explore non-generative encounters and hence to address the question of the possibility of being without being in relation. Drawing from an unorthodox line of research, the article unearths non-relational, or beyond-the-relational, instances, whose engagement with an entangled world can only be materialised through the logics of subjugation. For this mode of being, the texts hints, non-engagement, refusal, and withdrawal become a form of political resistance and survival, thus distorting the controversial association between political subjectivity and emancipation.
High risk of necrotising enterocolitis in term-born neonates with CHD delivered by caesarean section: a case–control study
Authors: Ihle Eloise , Thompson Jenny , Butt Warwick , Namachivayam Siva P. 
Published: August 2023

AbstractObjective:Necrotising enterocolitis is linked with altered intestinal microbiota, and caesarean birth is associated with imbalance of newborn intestinal microbiome. We aimed to investigate the role of delivery mode (vaginal or caesarean) and gestational age in the development of necrotising enterocolitis among term-born neonates (≥ 37 weeks) with CHD.Methods:Case–control study. We studied all newborns with CHD who underwent cardiac surgery during the neonatal (≤ 28 days of age) period, between 2007 and 2017. Totally, 60 cases of necrotising enterocolitis were matched (by year of birth and type of congenital heart lesion) with 180 controls (1:3 ratio). Multivariable conditional logistic regression was used to assess the study question.Results:The overall prevalence of necrotising enterocolitis was 6.3% in term-born newborns with CHD. Neonates with a left-ventricular outflow tract lesion or single ventricle lesion accounted for 55% (n = 33) of cases. 62% (n = 37) cases were in the modified Bell’s stage 2 or more for necrotising enterocolitis classification. In multivariable modelling, gestational age at birth was not associated with the development of necrotising enterocolitis [adjusted odds ratio per week increase, 95% confidence interval: 1.20 (0.90–1.60)]. Birth by caesarean delivery (compared to vaginal) was strongly associated with development of necrotising enterocolitis [adjusted odds ratio (95% confidence interval): 2.64 (1.31–5.29)]. We failed to identify an association between preoperative enteral nutrition and necrotising enterocolitis.Conclusion:This study showed a high risk of necrotising enterocolitis in newborns with critical CHD born via caesarean. This information is important given the high prevalence of planned birth by caesarean in newborns with CHD.
Predictors of the inability to achieve full oral feeding in postoperative infants with CHD
Authors: Jacobwitz Marin , Irving Sharon Y. , Moriarty Helene , Yost Jennifer , Vossough Arastoo , Licht Daniel J. , Lynch Jennifer M. 
Published: August 2023

AbstractObjectives:Poor oral feeding is a known contributor to growth challenges in neonates with complex CHD who require early surgery. Almost 60% of these infants do not achieve full oral feeding by hospital discharge. This study’s objective was to identify predictors of the inability to achieve full oral feeding by discharge in neonates with complex CHD following surgical intervention with cardiopulmonary bypass.Study Design:A retrospective analysis of a prospective study of 192 full-term neonates with complex CHD was performed. A stepwise selection logistic regression model was developed to predict oral feeding status at hospital discharge. Univariate subgroup analysis was performed with groups determined based on a CHD classification system.Results:58% of neonates (112/192) failed to achieve full oral feeding by hospital discharge. A logistic regression model identified duration of deep hypothermic circulatory arrest and reintubation as predictors of the inability to achieve full oral feeding. Among neonates who achieved full oral feeding by discharge (42%), only 7.5% did so after postoperative day 10. Brain maturation, brain injury, and preoperative oral feeding were not predictors of full postoperative oral feeding.Conclusions:Many infants with CHD fail to achieve full oral feeding by time of hospital discharge. Longer duration of deep hypothermic circulatory arrest and increased number of intubations were predictive of poor feeding after surgery. Prolonging hospitalisation solely to achieve full oral feeding after postoperative day ten is of limited utility; earlier discharge should be promoted to avoid negative impacts on neonatal neurodevelopment as unintended consequences of lengthy hospitalisations.
ODD RANK VECTOR BUNDLES IN ETA-PERIODIC MOTIVIC HOMOTOPY THEORY
Authors: Haution Olivier 
Published: August 2023

AbstractWe observe that, in the eta-periodic motivic stable homotopy category, odd rank vector bundles behave to some extent as if they had a nowhere vanishing section. We discuss some consequences concerning$\operatorname {\mathrm {SL}}^c$-orientations of motivic ring spectra and the étale classifying spaces of certain algebraic groups. In particular, we compute the classifying spaces of diagonalisable groups in the eta-periodic motivic stable homotopy category.
A Southern White Clergyman, the Freed People, and the Nineteenth-Century Episcopal Church
Authors: Mead Loren B. , Martinez J. Michael 
Published: August 2023

AbstractReared in antebellum South Carolina, Peter Fayssoux Stevens was a typical white southerner until Reconstruction. He came of age in the 1840s and 1850s and fought for the Southern Confederacy during the Civil War. Before his military service commenced in 1861, he was ordained a priest in the Protestant Episcopal Church (PEC) of North America. After Appomattox, as Black communicants deserted white Protestant churches in droves, Stevens believed that they might return to the PEC if they could choose their leaders and decide fundamental questions affecting their parishes. When white church leaders refused to follow Stevens’s recommendations, he left the PEC and joined the Reformed Episcopal Church (REC). He spent more than four decades after the war ministering to Black communicants. Although Stevens was not a champion of civil rights, his career provides a compelling case study of a white clergyman who evolved from a traditional southerner and zealous Confederate soldier to an advocate for Black communicants in the church.
As clear as Herculaneum mud: a plea for clarity
Authors: Moran Jerome 
Published: August 2023

AbstractThis article is by way of a request to experts who wish to make their expertise accessible to the non-expert. Non omnia possumus omnes, as Virgil said. In this case the deficiency is the lack of familiarity with papyrology and its conventions, in particular the papyri discovered in the library of the Villa of the Papyri at Herculaneum. The article shows how expertise can hinder rather than help the understanding of information needed for the processing of crucial data by the non-expert.
Discussion and Fairness in a Laboratory Voting Experiment
Authors: Woon Jonathan , Jang Minsu , Pronin Kira , Schiller Jacob 
Published: August 2023

AbstractWe conduct a laboratory experiment to investigate whether public discussion before a majority vote increases the saliency of minority interests and results in more egalitarian outcomes or whether voters use discussion to form majorities that benefit at the expense of minorities. When there are two alternatives, we find that public discussion increases the likelihood that individuals vote for equal allocations, but has little to no impact on the group outcomes. When participants choose among one equal and several unequal options, the multitude of unequal options creates a coordination problem, and we find that discussion decreases the frequency of egalitarian decisions. Our findings suggest that the effect of public communication on the fairness of majority voting outcomes depends on the strategic environment.
A Stable Isotope Sclerochronology‐Based Forensic Method for Reconstructing Debris Drift Paths With Application to the MH370 Crash
Authors: Al‐Qattan Nasser , Herbert Gregory S. , Spero Howard J. , McCarthy Sean , McGeady Ryan , Tao Ran , Power Anne‐Marie 
Published: August 2023

AbstractA flaperon belonging to Malaysian Airlines flight MH370 washed ashore on Réunion Island covered with the barnacle Lepas anatifera in July 2015, more than a year after the plane's disappearance. Here, we report the first high‐precision δ18Ocalcite versus temperature relationship for L. anatifera reared under laboratory conditions to unlock clues to the flaperon's drift path and origin. Using this experimental relationship and known growth rates for L. anatifera, we also demonstrate a new method for (a) converting δ18O data for one of the MH370 barnacles into a dated time series of sea surface temperatures (SSTs) experienced during the last part of the flaperon's drift and (b) identifying best fits between the observed flaperon SST time series and 50,000 SST histories generated from a particle‐tracking simulation. Our new method identifies a flaperon drift path far south of a previous isotope‐based reconstruction. We conclude with specific recommendations for using our method to continue the search for MH370 and other applications.
Pacific Decadal Oscillation Forecasting With Spatiotemporal Embedding Network
Authors: Qin Mengjiao , Hu Linshu , Qin Zhuoya , Wan Lin , Qin Lianjie , Cao Wenting , Wu Sensen , Du Zhenhong 
Published: August 2023

AbstractThe Pacific decadal oscillation (PDO) is a decadal variability phenomenon occurring in the North Pacific Ocean. It has substantial impacts on marine ecosystems and the global climate. Due to the high complexity and unclear evolution mechanism, the accurate long‐term prediction of PDO remains a challenge. In this paper, a deep spatiotemporal embedding network (DSEN) is proposed to extract the spatiotemporal features from historical climate data and achieve end‐to‐end forecasting of the PDO index. The spatiotemporal features are recursive in the continuous forecasting of the PDO index on seasonal time scales, thus the cumulative error is largely reduced. During the test period of 39 years (1982–2020), our model can skillfully predict the PDO index up to 1 year, outperforming six methods used as benchmark. By contrast with physically‐based methods, DSEN can accurately predict the PDO index from a data‐driven perspective.
A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal
Authors: Luo Min , Wang Xueping , Wu Shaocong , Yang Chuan , Su Qiao , Huang Lamei , Fu Kai , An Sainan , Xie Fachao , To Kenneth Kin Wah , Wang Fang , Fu Liwu 
Published: August 2023

AbstractImmune checkpoint inhibitors (ICIs) have induced durable clinical responses in a subset of patients with colorectal cancer (CRC). However, the dis-satisfactory response rate and the lack of appropriate biomarkers for selecting suitable patients to be treated with ICIs pose a major challenge to current immunotherapies. Inflammation-related molecule A20 is closely related to cancer immune response, but the effect of A20 on “eat-me” signal and immunotherapy efficacy remains elusive. We found that A20 downregulation prominently improved the antitumor immune response and the efficacy of PD-1 inhibitor in CRC in vitro and in vivo. Higher A20 expression was associated with less infiltration of immune cells including CD3 (+), CD8 (+) T cells and macrophages in CRC tissues and also poorer prognosis. Gain- and loss-A20 functional studies proved that A20 could decrease the “eat-me” signal calreticulin (CRT) protein on cell membrane translocation via upregulating stanniocalcin 1 (STC1), binding to CRT and detaining in mitochondria. Mechanistically, A20 inhibited GSK3β phosphorylating STC1 at Thr86 to slow down the degradation of STC1 protein. Our findings reveal a new crosstalk between inflammatory molecule A20 and “eat-me” signal in CRC, which may represent a novel predictive biomarker for selecting CRC patients most likely to benefit from ICI therapy.
The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment
Authors: Liu Li-Zhong , Wang Bowen , Zhang Rui , Wu Zangshu , Huang Yuxi , Zhang Xiaoyang , Zhou Jiaying , Yi Junbo , Shen Jian , Li Ming-Yue , Dong Ming 
Published: August 2023

AbstractObesity/overweight and lipid metabolism disorders have become increased risk factors for lung cancer. Fatty acid translocase CD36 promotes cellular uptake of fatty acids. Whether and how CD36 facilitates lung adenocarcinoma (LUAD) growth in high-fat environment is unknown. Here, we demonstrated that palmitic acid (PA) or high-fat diet (HFD) promoted LUAD cell proliferation and metastasis in a CD36-dependent manner. Mechanistically, CD36 translocated from cytoplasm to cell membrane and interacted with Src kinase upon PA stimulation in human LUAD cells. Akt and ERK, downstream of Src, were then activated to mediate LUAD cell proliferation and metastasis. Furthermore, PA treatment promoted CD36 sarcolemmal translocation, where it activated Rac1 and upregulated MMP-9 through Src-Akt/ERK pathway, resulting in redistribution of cortactin, N-WASP and Arp2/3, and finally led to occurrence of finger-like protrusions of actin on cell surface to enhance cell metastasis. Compared with normal-chew diet (NCD) mice, the HFD group exhibited higher level of blood free fatty acid (FFA) and cholesterol (TC), developed larger xenograft LUAD tumors and enhanced tumor cell metastatic potential, which were accompanied by obvious sarcolemmal actin remodeling and were blocked by simultaneous CD36 knockdown in LUAD cells. Consistently, xenografted and tail vein-injected scramble-RNA-A549 cells but not CD36-shRNA-A549 in HFD mice formed metastatic LUAD tumors on the lung. CD36 inhibitor SSO significantly inhibited LUAD cell metastasis to the lung. Collectively, CD36 initiates Src signaling to promote LUAD cell proliferation and actin remodeling-involved metastasis under high-fat environment. Our study provides the new insights that CD36 is a valid target for LUAD therapy.
C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression
Authors: Wan Yangu , Adair Kareena , Herrmann Anne , Shan Xindi , Xia Lijun , Duckworth Carrie A. , Yu Lu-Gang 
Published: August 2023

AbstractAlthough most cell membrane proteins are modified by glycosylation, our understanding of the role and actions of protein glycosylation is still very limited. β1,3galactosyltransferase (C1GalT1) is a key glycosyltransferase that controls the biosynthesis of the Core 1 structure of O-linked mucin type glycans and is overexpressed by many common types of epithelial cancers. This study reports that suppression of C1GalT1 expression in human colon cancer cells caused substantial changes of protein glycosylation of cell membrane proteins, many of which were ligands of the galactoside-binding galectin-3 and the macrophage galactose-type lectin (MGL). This led to significant reduction of cancer cell proliferation, adhesion, migration and the ability of tumour cells to form colonies. Crucially, C1GalT1 suppression significantly reduced galectin-3-mediated tumour cell-cell interaction and galectin-3-promoted tumour cell activities. In the meantime, C1GalT1 suppression substantially increased MGL-mediated macrophage-tumour cell interaction and macrophage-tumour cell phagocytosis and cytokine secretion. C1GalT1-expressing cancer cells implanted in chick embryos resulted in the formation of significantly bigger tumours than C1GalT1-suppressed cells and the presence of galectin-3 increased tumour growth of C1GalT1-expressing but not C1GalT1-suppressed cells. More MGL-expressing macrophages and dendritic cells were seen to be attracted to the tumour microenvironment in ME C1galt1-/-/Erb mice than in C1galt1f/f /Erb mice. These results indicate that expression of C1GalT1 by tumour cells reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression. C1GalT1 overexpression in epithelial cancers therefore may represent a fundamental mechanism in cancer promotion and in reduction of immune response/surveillance in cancer progression.