bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia
Authors: Salomao Norman , Maslah Nabih , Giulianelli Anouk , Drevon Louis , Aguinaga Lorea , Gu Xiaolian , Cassinat Bruno , Giraudier Stephane , Fenaux Pierre , Fahraeus Robin 
Published: December 2022

SummaryThe human homologues of murine double minute 2 (MDM2) and 4 (MDM4) negatively regulate p53 tumour suppressor activity and are reported to be frequently overexpressed in human malignancies, prompting clinical trials with drugs that prevent interactions between MDM2/MDM4 and p53. Bone marrow samples from 111 patients with acute myeloblastic leukaemia, myelodysplastic syndrome or chronic myelomonocytic leukaemia were examined for protein (fluorescence‐activated cell sorting) and messenger RNA (mRNA) expression (quantitative polymerase chain reaction) of MDM2, MDM4 and tumour protein p53 (TP53). Low protein expression of MDM2 and MDM4 was observed in immature cells from patients with excess of marrow blasts (>5%) compared with CD34+/CD45low cells from healthy donors and patients without excess of marrow blasts (<5%). The mRNA levels were indistinguishable in all samples examined regardless of disease status or blast levels. Low MDM2 and MDM4 protein expression were correlated with poor survival. These data show a poor correlation between mRNA and protein expression levels, suggesting that quantitative flow cytometry analysis of protein expression levels should be used to predict and validate the efficacy of MDM2 and MDM4 inhibitors. These findings show that advanced disease is associated with reduced MDM2 and MDM4 protein expression and indicate that the utility of MDM2 and MDM4 inhibitors may have to be reconsidered in the treatment of advanced myeloid malignancies.
Phorophyte size and soil profiles differentially correlate with community structure among hemiepiphytes and nomadic vines
Authors: Clemente‐Arenas Edith Rosario , Trujillo‐Rodriguez Lucio Royer , Hilário Renato Richard , Irume Mariana Victória , Zartman Charles E. , de Toledo José Julio 
Published: December 2022

AbstractTropical non‐self‐supporting plants such as hemiepiphytes and nomadic vines are model organisms for disentangling biotic and environmental correlates which influence their occupancy patterns. We inventoried >4000 individuals from >3000 trees ranging from 1 to 200 cm diameter at breast height (DBH) in a northeastern Amazonian upland forest to address how tree (phorophyte) size, edaphic factors and recruitment strategy influence occupancy, diversity, and compositional patterns of two vascular non‐self‐supporting plant functional groups. Hemiepiphytes germinate on phorophytes prior to establishing soil connections, whereas nomadic vines initiate their life cycle on the forest floor and subsequently climb phorophytes for crown access, abandoning roots replaced by adventitious connections which may reach the ground. Our results show that larger phorophytes (≥30 cm DBH) supported more species for both hemiepiphytes and nomadic vines. However, nomadic vines' occupancy probabilities saturated faster at smaller stem sizes than that of hemiepiphytes indicating differential preferences for stem sizes among the two functional groups. For smaller phorophytes (<30 cm DBH), soil correlations were stronger with nomadic vines than hemiepiphytes, whereas no significant differences were detected among functional groups in relation to edaphic factors for larger (≥ 30 cm DBH) ones. Finally, a small core group of species showed disproportionately greater abundances among large phorophytes suggesting that autogenic processes differentially promote survivability. Such interactions among phorophyte size and edaphic factors may result from the contrasting ecological requirements of hemiepiphytes and nomadic vines at the recruitment stage, demonstrating the necessity for elaborate demographic‐based studies to better understand these complex plant–plant interactions.Abstract in Spanish is available with online material
Discovery and evaluation of biphenyl derivatives of 2‐iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity
Authors: Babkov Denis A. , Zhukovskaya Olga N. , Brigadirova Anastasia A. , Prilepskaya Diana R. , Kolodina Alexandra A. , Abbas Abbas Haider S. , Morkovnik Anatolii S. , Sobhia M. Elizabeth , Ghosh Ketan , Spasov Alexander A. 
Published: December 2022

AbstractThis work describes the synthesis of series hydrobromides of N‐(4‐biphenyl)methyl–N′‐dialkylaminoethyl‐2‐iminobenzimidazoles, which, due to the presence of two privileged structural fragments (benzimidazole and biphenyl moieties), can be considered as bi‐privileged structures. Compound 7a proved to activate AMP‐activated kinase (AMPK) and simultaneously inhibit protein tyrosine phosphatase 1B (PTP1B) with similar potency. This renders it an interesting prototype of potential antidiabetic agents with a dual‐target mechanism of action. Using prove of concept in vivo study, we show that dual‐targeting compound 7a has a disease‐modifying effect in a rat model of type 2 diabetes mellitus via improving insulin sensitivity and lipid metabolism.
Gender inequities in dental research publications: Findings from 20 years
Authors: Haag Dandara Gabriela , Schuch Helena Silveira , Nath Sonia , Baker Sarah R. , Celeste Roger Keller , Thomson W. Murray , Jamieson Lisa M. 
Published: December 2022

AbstractBackgroundThe first steps towards gender equity in science are measuring the magnitude of inequity and increasing awareness of the problem.ObjectivesTo describe trends in gender disparities in first and last authorship in the most cited dental publications and general dental literature over a 20‐year period.MethodsArticles and bibliometric data were retrieved from the Scopus database for the period 1996 to 2015. Two groups of 1000 articles each were retrieved: a random sample and another sample of top‐cited articles for each year. The gender of the first and last author of each publication was manually identified. When this was not possible, we used an online software platform (https://genderize.io/). Descriptive analyses identified the proportion of women first and last authors in both samples, stratifying by dental discipline and geographic region. Trends were ascertained by frequency metrics across years. Gender disparity was observed in both first and last authorship, with a larger gap being observed in the top‐cited sample.ResultsWomen led 28.4% and 20.3% of articles in the random and top‐cited samples, respectively. A similar pattern was observed for the last authorship group (22.1% and 16.1%, respectively). An increasing trend in the proportion of articles led by women over time was observed in both samples. This increase was larger in the top‐cited sample (from 15.0% in 1996–2000 to 25.1% in 2015) than in the random sample (from 26.3% in 1996–2000 to 33.2% in 2011).ConclusionsClear gender disparities in dental research publications in the last 20 years were identified in both general and top‐cited manuscripts, across dental disciplines, across countries, across first and last authorship, and over time. It is paramount that actions are taken to attract, retain and promote women in science, as well as to monitor and ensure progress towards gender equity.
ROSAH syndrome mimicking chronic uveitis
Authors: Fardeau Christine , Alafaleq Munirah , Dhaenens Claire‐Marie , Dollfus Hélène , Koné‐Paut Isabelle , Grunewald Olivier , Morel Jean‐Baptiste , Titah Cherif , Saadoun David , Lazeran Patrice Olivier , Meunier Isabelle 
Published: December 2022

AbstractTo suggest a unique missense variant candidate based on long‐term ophthalmological changes and associated systemic signs described in five patients from two unrelated families affected by an autosomal dominant multi‐systemic disorder including Retinal dystrophy, Optic nerve oedema, Splenomegaly, Anhidrosis and migraine Headaches, called ROSAH syndrome, related to a unique missense variant in ALPK1 gene. Observational longitudinal follow‐up study of unrelated families. Clinical analysis of ophthalmological and systemic examinations was performed, followed by genetic analysis, including targeted Next Generation Sequencing (NGS) and Whole‐Genome Sequencing (WGS). The ophthalmological phenotype showed extensive optic nerve swelling associated with early macular oedema and vascular leakage. The main associated systemic manifestations were recurrent fever, splenomegaly, anhidrosis, mild cytopenia, anicocytosis and hypersegmented polynuclear cells. WGS, shortened in the second family by the gene candidate suggestion, revealed in all patients the heterozygous missense variant c.710C>T; p.(Thr237Met) in ALPK1. The primary morbidity in ROSAH syndrome in this cohort appeared ophthalmological. Comprehensive, detailed phenotype changes aided by the advancement in genetic testing could allow an early genetic diagnosis of ROSAH syndrome and targeted treatment. The unique missense variant may be suggested as a target of gene correction therapy.
Implementing land acquisitions for watershed services in the tropical Colombian Andes produces marginal progress for advancing area‐based conservation objectives
Authors: Reboredo Segovia Ana L. , Matallana Clara , Amaya Torres Daniela , Meza Chavez Daniella , Gómez Candamil Juan Felipe , López Gamboa Verónica , Nolte Christoph 
Published: December 2022

AbstractThe biodiversity crisis necessitates a global implementation of effective, equitable, and feasible conservation strategies. Public land acquisitions (PLAs) for watershed protection can produce co‐benefits for basic human needs and biodiversity, but there are concerns that acquiring land is not scalable or may not protect threatened biodiversity. PLA programs are rare, allowing for limited opportunities to assess these concerns. We investigate a unique policy that has legally mandated PLAs in the Colombian Andes, a tropical biodiversity hotspot, since 1993. Using a novel dataset of >7000 PLAs, along with surveys and in‐person interviews, we study the scale, spatial allocation, and constraints on PLA implementation, and examine its potential conservation benefits. More than 300,000 ha were acquired through PLAs, but economic and institutional factors such as land cost, government income, and land tenure informality were main drivers in the degree of PLA implementation. Acquisitions were thus directed mostly toward cheaper, less threatened ecosystems.
Eukaryotic translation initiation factor eIF4G2 opens novel paths for protein synthesis in development, apoptosis and cell differentiation
Authors: Liu Yudi , Cui Jiuwei , Hoffman Andrew R. , Hu Ji‐Fan 
Published: December 2022

AbstractProtein translation is a critical regulatory event involved in nearly all physiological and pathological processes. Eukaryotic translation initiation factors are dedicated to translation initiation, the most highly regulated stage of protein synthesis. Eukaryotic translation initiation factor 4G2 (eIF4G2, also called p97, NAT1 and DAP5), an eIF4G family member that lacks the binding sites for 5′ cap binding protein eIF4E, is widely considered to be a key factor for internal ribosome entry sites (IRESs)‐mediated cap‐independent translation. However, recent findings demonstrate that eIF4G2 also supports many other translation initiation pathways. In this review, we summarize the role of eIF4G2 in a variety of cap‐independent and ‐dependent translation initiation events. Additionally, we also update recent findings regarding the role of eIF4G2 in apoptosis, cell survival, cell differentiation and embryonic development. These studies reveal an emerging new picture of how eIF4G2 utilizes diverse translational mechanisms to regulate gene expression.
Utilization and outcomes of rescue hepatectomy among U.S. liver retransplant candidates
Authors: Kathawate Ranganath G. , Ibeabuchi Tobenna , Abt Peter L. , Bittermann Therese 
Published: December 2022

AbstractIntroductionThe frequency and outcomes of anhepatic patients listed for transplantation in the United States have not been studied. The United Network for Organ Sharing (UNOS) records anhepatic status for patients listed as Status 1A for hepatic artery thrombosis (HAT) or primary non‐function (PNF).MethodsUsing the UNOS database from 2005 to 2020, demographics and waitlist outcomes of anhepatic candidates relisted as Status 1A for HAT or PNF were assessed.ResultsAmong 1364 adult Status 1A patients relisted for PNF or HAT across 120 distinct transplant centres, 75 (5.5%) patients were anhepatic and 1289 (94.5%) were non‐anhepatic. A substantial number of centres (n = 51) had experience with ≥1 anhepatic patient relisted for either PNF or HAT, with individual centre rates ranging from 0% to 11.4%. Waitlist mortality was more than twice as high for anhepatic patients: 42.5% versus 17.0% non‐anhepatic patients (p < .001). The post‐transplant outcomes of anhepatic patients were markedly inferior to non‐anhepatic patients. For example, 41.9% of anhepatic patients died during the index admission versus 23.4% of the non‐anhepatic group (p = .006). Patient survival for the anhepatic and non‐anhepatic groups was 48.3% versus 66.2% at 1‐year and 29.3% versus 46.2% at 5‐years, respectively (log‐rank test for overall survival p = .014).ConclusionsRescue hepatectomy after initial liver transplantation is not only associated with high waitlist mortality, but also markedly worse post‐transplant outcomes. With less than half of anhepatic patients surviving to the first year post‐LT, further research is warranted to better delineate which patients should be considered for rescue hepatectomy.
Reconstructing Pragmatism in the New Climate Regime: Education After the Intrusion of Gaia
Authors: Oliverio Stefano 
Published: December 2022

AbstractIn this essay, Stefano Oliverio engages with the question of how to think about education in times of climate change and the “intrusion of Gaia” by establishing a dialogue between Bruno Latour's political ecology and John Dewey's appeal to the need to bring a genuine Copernican revolution to fruition. Oliverio argues that the panoply of conceptual tools Dewey fashioned by recognizing the influence of Darwin on philosophy not only maintains its topicality but can be fruitfully deployed to make sense of our contemporary condition and to frame an earthbound education. On the other hand, the encounter with the views of contemporary thinkers reflecting on the New Climate Regime and the endeavors it invokes may help us to recontextualize the Deweyan heritage in order to “face Gaia.” In this horizon, the idea of the school as a site of collective inquiry is acclimatized to the new existential situation, and its significance in promoting an art of the learning of attention to contrast the contemporary negligence and risk of barbarism is vindicated.
The Will to Believe in this World: Pragmatism and the Arts of Living on a Precarious Earth
Authors: Savransky Martin 
Published: December 2022

AbstractThe patterns of ecological devastation that mark the present unexpectedly enable an ancient and many‐storied question to resurface with renewed force: the question of the arts of living — that is, of learning how to live and die well with others on a precarious Earth. Modernity has all but forgotten this question, which has long been buried under the dreams of progress and infinite growth, colonial projects, and the enthroning of technoscience. But what might it mean to reclaim the question of the arts of living today? In this article Martin Savransky reclaims the connection between pragmatism, education, and the arts of living by proposing both that (1) William James's pragmatist philosophy can be read as an ongoing and unfinished experiment in weaving a certain art of living, and (2) James's pragmatism might provide us with uniquely generative elements to begin to experiment with the profoundly educational and ecological challenge of learning to inhabit the Earth otherwise.
When corruption investigations come to nothing: A natural experiment on trust in courts
Authors: Magalhães Pedro C. 
Published: December 2022

AbstractCorruption scandals and their investigation have been shown to undermine support not only for the allegedly involved public officials but also for political actors and institutions more generally. However, we know little about what happens when those investigations end up failing to result in punishments. Is citizens' trust in the legal authorities in charge of prosecuting and punishing corruption also undermined? Do those effects spill over to political actors, institutions, and even the political regime? We address these questions by taking advantage of an April 2021 judicial decision to drop corruption charges against former Portuguese Prime Minister José Sócrates during the fieldwork of a public opinion survey. We show that the decision had a substantial negative impact on public trust in the courts. Furthermore, although political trust was not immediately affected, its overall levels also became lower in comparison to periods before the judicial decision, suggesting a spillover effect.
The role of topical therapies along the psoriasis patient journey: An overview from the Symposium ‘Tailoring topical psoriasis treatments to patients' needs and expectations’ of the 30thEADV Congress 2021
Authors: Pinter Andreas , van de Kerkhof Peter 
Published: December 2022

AbstractThis article summarizes a presentation titled ‘The role of topical therapies along the psoriasis patient journey’ held at the Satellite Symposium of the 30th European Academy of Dermatology and Venereology Congress. During this session, the role of topical treatments in the management of psoriasis was presented, with a particular focus on the current unmet needs and data gaps. Psoriasis plays a significant role in a patient's daily life, impacting them not only physically but also psychologically and socially. The disease burden increases with duration and severity. Topical therapies are the keystone of the management of psoriasis. About 70%–80% of patients present a mild‐to‐moderate form of psoriasis that can be successfully treated with topical agents. According to a German recommendation, patients with mild psoriasis should initiate a topical therapy in combination with skin care products. In the real‐life setting, the calcipotriol/betamethasone dipropionate (CAL/BDP) fixed combination was the most prescribed topical treatment for beyond‐mild patients in Germany, Spain and the United Kingdom. Healthcare professionals also often or very often prescribed topicals as an alternative to non‐biologic systemics in certain situations, such as patient preference (51%), contraindication (50%) and to limit side effects (26%). Adjunctive topical therapy to patients using systemic therapy is used to optimize treatment outcomes and improving the quality of life for patients. Topical treatments can be also effective in severe forms of psoriasis. However, there are still some gaps and unmet needs on topical therapy. Ineffectiveness, patient dissatisfaction and adherence are the largest barriers to treatment success. Main strengths of topical treatments include the availability of various topical ingredients and galenics, the adaptability to different anatomical areas and the possible combination with phototherapy and systemics. Moreover, patients in specific situations can benefit from switching to topical treatments (e.g. pregnancy or surgery).
Identifying the cooling heterogeneity and quality decay of Indian mangoes during cold chain export by multiphysics modeling
Authors: Pattanaik Swati , Jenamani Mamata 
Published: December 2022

AbstractPrediction and analysis of temperature‐based quality evolution of those perishables subjected to extreme temperatures in a shipment can guide the stakeholders and decision‐makers regarding the final quality of shipment and export mode. This study aims to forecast the temperature heterogeneity among the perishables packed in a standard ventilated carton for sea‐borne cold chain and airways export, using Computational Fluid Dynamics (CFD) simulation. The biochemical processes affecting the fruit quality are also evaluated, and the overall quality is predicted with the help of the Kinetic rate law model. The case of an Indian mango export to United States is considered for the present study, and a preferable export mode is suggested. The model is experimentally validated with a discrepancy of 1.516 K (RMSE) and 9.504% (MAPE), respectively. The findings indicate more heterogeneous temperature distribution in the case of seaways export (nearly 3 K) compared to airways (1.5 K). The temperature‐dependent quality attributes, following different kinetics, decays by 46% and 89.6% on the 10th day of seaways export. This observation indicates that the mangoes will be spoiled in transit as seaways export to United States takes around 28 days. From these observations, under the given transit conditions, it is recommended to export mangoes via airways to the United States from India, which takes about 3 days.Practical ApplicationsMonitoring the temperature of perishables is an indispensable part of cold chain export for maintaining their quality and extending their shelf life. This study proposes a virtual or simulation‐based approach to analyze the cooling behavior of individual mangoes and hence predict the evolution of its various quality attributes, passing through different stages of the cold chain. The technique used is quite promising in predicting the export potential and export mode of the produce before the actual export process takes place, thus preventing excessive in‐transit loss. The method mentioned above is applied in an illustrative case study of Indian mango export to the United States. Its application can be further extended to the export of other perishables to various importing countries.
A three‐dimensional printed assembled sleeveless guide system for fiber‐post removal
Authors: Xue Yang , Zhang Lei , Cao Ye , Zhou Yongsheng , Xie Qiufei , Xu Xiaoxiang 
Published: December 2022

AbstractThis report describes a technique to develop a three‐dimensional printed assembled sleeveless guide system to aid the fiber‐post removal in a safe and efficient way. The surface and volume data of the dentition containing the targeted tooth were acquired with optical scanners and cone‐beam computed tomography. The virtual path of the fiber‐post removal was determined and integrated with a guide prototype with a cylindrical passage. The prototype data was split into two separate parts, combined with the matched pin and jack structures to facilitate the assembly. A guide tube was generated based on the axis of the cylindrical passage, split into three units, and combined with the previously processed data with connectors to form the finalized guide system. The adaptor for the head of handpiece was designed to facilitate the guidance. All the finalized data were printed with titanium alloy. The fiber‐post of the upper right central incisor was successfully removed with the aid of this assembled sleeveless guide system that guides the handpiece rather than the rotary instrument.