Clinical Practice Guidelines for Pancreatic Cancer 2022 from the Japan Pancreas Society: a synopsis
Authors: Okusaka Takuji , Nakamura Masafumi , Yoshida Masahiro , Kitano Masayuki , Ito Yoshinori , Mizuno Nobumasa , Hanada Keiji , Ozaka Masato , Morizane Chigusa , Takeyama Yoshifumi ,   the Committee for Revision of Clinical Guidelines for Pancreatic Cancer of the Japan Pancreas Society, Sakamoto Yasunari , Inoue Dai , Kamata Ken , Kawai Manabu , Kanno Atsushi , Serikawa Masahiro , Sofuni Atsushi , Takayama Yukiko , Matsubayashi Hiroyuki , Ohtsuka Takao , Onoe Shunsuke , Kawai Manabu , Sho Masayuki , Fujii Tsutomu , Matsumoto Ippei , Matsuyama Ryusei , Mizuma Masamichi , Yamamoto Tomohisa , Ioka Tatsuya , Eguchi Hidetoshi , Someya Masanori , Nakata Kohei , Nakamura Satoaki , Ohguri Takayuki , Shinoto Makoto , Someya Masanori , Nakamura Satoaki , Ioka Tatsuya , Ueno Makoto , Itoi Takao , Isayama Hiroyuki , Kato Hironari , Nakai Yousuke , Uemura Keiichi , Oyakawa Takuya , Sakamoto Hatoe , Shimizu Yoichi , Tagami Keita , Tsuji Tetsuya , Fujimori Maiko , Mitsunaga Shuichi , Mori Masanori , Yokokawa Takashi , Kanai Masashi , Matsubayashi Hiroyuki , Osada Shoji , Shimizu Yoichi , Furutani Sawako , Majima Yoshiyuki , Mori Masanori , Yamaguchi Naohiko , Narita Natsuki , Okumura Akiko , Shima Kyoko , Sakamoto Yasunari , Kondo Keiko , Akizuki Nobuya , Ashida Reiko , Ikenaga Naoki , Ishii Yasutaka , Ishii Shigeto , Ideno Noboru , Inaba Koji , Uneno Yu , Umezawa Rei , Ohgi Katsuhisa , Ohba Akihiro , Omoto Shunsuke , Okajima Yoshiro , Ono Yuka , Kasuga Akiyoshi , Kamei Keiko , Kurahara Hiroshi , Kuramochi Hidekazu , Kurihara Keisuke , Kuwahara Takamichi , Kobayashi Kazuo , Kobayashi Satoshi , Kondo Tomohiro , Saito Kei , Shiga Taro , Shibuki Taro , Shibuya Kazuto , Shimizu Akinori , Shimizu Yasuhiro , Takahashi Hidenori , Takahara Naminatsu , Tsuchiya Takaaki , Tsuchiya Takayoshi , Tsuboi Tomofumi , Toshima Fumihito , Tomishima Ko , Nagai Hiroki , Nakagawa Kenji , Hamada Tsuyoshi , Higashigawa Satomi , Higuchi Yuji , Hiratsuka Yusuke , Fujisawa Toshio , Funahashi Hideki , Matsumoto Kazuyuki , Miura Takayuki , Mie Takafumi , Minaga Kosuke , Miyake Kentaro , Miyazawa Motoki , Miwata Tetsurou , Muraoka Kaori , Yabushita Yasuhiro , Yamaki So , Yamazaki Tomohiro , Yamashita Yasunobu , Yamada Kensuke , Yamamoto Kenjiro , Yokoyama Kensuke , Yokoyama Yukihiro , Yoshioka Isaku , Yamaguchi Koji , Shimizu Kyoko , Sugiyama Masanori , Nakagohri Toshio , Nakamuta Makoto , Hatakeyama Yosuke , Furuse Junji , Motoi Fuyuhiko , Yamao Kenji , Watanabe Masato , Ishikawa Eiji , Kitano Atsuko , Takagaki Nobumasa , Tokumasu Hironobu , Noto Hiroshi 
Published: March 2023

Abstract
Objectives
Clinical Practice Guidelines for Pancreatic Cancer was first published in 2006 by the Japan Pancreas Society, and revised in 2009, 2013, 2016, and 2019. In July 2022, Clinical Practice Guidelines for Pancreatic Cancer was newly revised in Japanese.

Methods
For this revision, we developed an entirely new guideline according to the Minds Manual for Guideline Development 2020, which includes the concepts of GRADE—Grading Recommendations Assessment, Development, and Evaluation, to enable a better understanding of the current guidelines. Patients and the public were actively involved in both the development and implementation of the guideline.

Results
The guideline includes algorithms for diagnosis, treatment, chemotherapy, and precision medicine of pancreatic cancer, and addresses 7 subjects: diagnosis, surgical therapy, adjuvant therapy, radiation therapy, chemotherapy, stent therapy, and supportive & palliative medical care. It includes 73 clinical questions and 112 statements. The statements correspond to the clinical questions, evidence levels, recommendation strengths, and agreement rates.

Conclusions
This guideline represents the most standard clinical and practical management guideline available until date in Japan. This is the English synopsis of the Clinical Practice Guidelines for Pancreatic Cancer 2022 in Japanese, and is an attempt to disseminate the Japanese guideline worldwide to introduce the Japanese approach to the clinical management of pancreatic cancer.