bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time series model for GLWB with surrender benefit and stochastic interest rate: Dynamic withdrawal approach
Authors: Singh Shakti , Arunachalam Viswanathan , Selvamuthu Dharmaraja 
Published: February 2023

AbstractThis study investigates the pricing problem of a variable annuity (VA) contract embedded with a guaranteed lifetime withdrawal benefit (GLWB) rider. VAs are annuities in which the value is linked to a bond and equity sub‐account fund. The guaranteed lifetime withdrawal benefit rider regularly provides a series of payments to the policyholder for the term of the policy while he/she is alive, regardless of portfolio performance. At the time of the policyholder's death, the remaining fund value is given to his nominee. Therefore, proper fund modeling is critical in the pricing of VA products. Several writers in the literature used a GBM model in which variance is considered to be constant to represent the fund value in a variable annuity contract. However, on the other hand, the returns on financial assets are non‐normally distributed in real life. A bit much Kurtosis, leverage effect, and Non‐zero Skewness characterize the returns. The generalized autoregressive conditional heteroscedastic (GARCH) models are also used for presenting a discrete framework for the pricing of GLWB. Still, the interest rate was kept constant without including the surrender benefit and the static withdrawal approach, which keeps the model far from the real scenario. Thus, in this research, the generalized GARCH models are used with surrender benefit and dynamic withdrawal strategy to develop a time series model for the pricing of annuity that overcomes the constraints of previous models. A numerical illustration and sensitivity analysis are used to examine the suggested model.
Detection of cancer‐associated miRNA using a fluorescence switch of AgNC@NA and guanine‐rich overhang sequences
Authors: Fredrick Dylan , Yourston Liam , Krasnoslobodtsev Alexey V. 
Published: February 2023

AbstractDNA‐templated silver nanoclusters (AgNC@DNA) are a novel type of nanomaterial with advantageous optical properties. Only a few atoms in size, the fluorescence of nanoclusters can be tuned using DNA overhangs. In this study, we explored the properties of AgNCs manufactured on a short single‐stranded (dC)12 when adjacent G‐rich sequences (dGN, with N = 3–15) were added. The ‘red’ emission of AgNC@dC12 with λMAX = 660 nm dramatically changed upon the addition of a G‐rich overhang with NG = 15. The pattern of the emission–excitation matrix (EEM) suggested the emergence of two new emissive states at λMAX = 575 nm and λMAX = 710 nm. The appearance of these peaks provides an effective way to design biosensors capable of detecting specific nucleic acid sequences with low fluorescence backgrounds. We used this property to construct an NA‐based switch that brings AgNC and the G overhang near one another, turning ‘ON’ the new fluorescence peaks only when a specific miRNA sequence is present. Next, we tested this detection switch on miR‐371, which is overexpressed in prostate cancer. The results presented provide evidence that this novel fluorescent switch is both sensitive and specific with a limit of detection close to 22 picomoles of the target miR‐371 molecule.
Response of peer relations and social activities to treatment with viloxazine extended‐release capsules (Qelbree®): A post hoc analysis of four randomized clinical trials of children and adolescents with attention‐deficit/hyperactivity disorder
Authors: Faraone Stephen V. , Gomeni Roberto , Hull Joseph T. , Busse Gregory D. , Lujan Brendan , Rubin Jonathan , Nasser Azmi 
Published: February 2023

AbstractIntroductionAttention‐deficit/hyperactivity disorder (ADHD) is associated with impairments related to peer relations (PR) and social activities (SA). The objective of this post hoc analysis was to assess the degree to which viloxazine extended‐release (viloxazine ER; viloxazine extended‐release capsules; Qelbree®) improves clinical assessments of PR and SA in children and adolescents with ADHD.MethodsData were used from four Phase III placebo‐controlled trials of 100 to 600 mg/day of viloxazine ER (N = 1354; 6–17 years of age). PR and SA were measured with the Peer Relations content scale of the Conners 3rd Edition Parent Short Form's Peer Relation content scale (C3PS‐PR) and the Social Activities domain of the Weiss Functional Impairment Rating Scale‐Parent Report's (WFIRS‐P‐SA) at baseline and end of study. ADHD symptoms were assessed weekly with the ADHD Rating Scale, 5th Edition. The analyses relied on the general linear mixed model with the subject as a random effect.ResultsImprovement in C3PS‐PR (p = .0035) and WFIRS‐P‐SA (p = .0029) scores were significantly greater in subjects treated with viloxazine ER compared with placebo. When using measures of clinically meaningful response, the C3PS‐PR responder rate was significantly higher for viloxazine ER (19.2%) compared with placebo (14.1%) and the difference was statistically significant (p = .0311); the Number Needed to Treat (NNT) was 19.6. The WFIRS‐P‐SA responder rate was significantly higher for viloxazine ER (43.2%) compared with placebo (28.5%) and the difference was statistically significant (p < .0001); the NNT was 6.8. The standardized mean difference effect size for both PR and SA was 0.09.ConclusionsViloxazine ER significantly reduces the impairment of PR and SA in children and adolescents with ADHD. Although its effects on PR and SA are modest, many ADHD patients can be expected to achieve clinically meaningful improvements in PR and SA with viloxazine ER treatment for longer than 6 weeks.
Strategies and practices to reduce the ecological impact of product returns: An environmental sustainability framework for multichannel retail
Authors: Zhang Danni , Frei Regina , Wills Gary , Gerding Enrico , Bayer Steffen , Senyo Prince Kwame 
Published: February 2023

AbstractProduct returns in retail are inherently wasteful and have considerable negative environmental impacts. Besides the monetary costs, they lead to increased transportation, packaging and processing, and the returned items are often discarded. We present strategies and practices retailers can adopt to manage their product returns in a way that reduces environmental impacts. With eCommerce flourishing, product returns have increased significantly. Whilst highest for online sales, they are a challenge across all channels. The importance of developing sustainability management in operations and supply chains is evident from the growing body of literature, but there is a gap regarding the management of product returns in a more environmentally sustainable manner. To address this gap, we interviewed multichannel retailers, retail experts and return service providers operating in the UK and North America. The findings reveal that although retailers have started paying attention to the financial impact of returns, there is little awareness of the scale of environmental impacts. In addition, retailers lack a comprehensive approach to addressing the environmental impact of product returns. Based on our findings, we (1) unpack the barriers inhibiting retailers from developing environmental sustainability plans in returns management, (2) present a set of strategies for retailers to reduce the environmental impact of returns and (3) develop a framework for environmental sustainability in returns management. Our findings and proposed framework have implications for research and practice on addressing the environmental impact of product returns.
An ultralow power wearable vital sign sensor using an electromagnetically reactive near field
Authors: Seo Seoktae , Jo Hyunkyeong , Kim Jungho , Lee Bonyoung , Bien Franklin 
Published: February 2023

AbstractDespite coronavirus disease 2019, cardiovascular disease, the leading cause of global death, requires timely detection and treatment for a high survival rate, underscoring the 24 h monitoring of vital signs. Therefore, telehealth using wearable devices with vital sign sensors is not only a fundamental response against the pandemic but a solution to provide prompt healthcare for the patients in remote sites. Former technologies which measured a couple of vital signs had features that disturbed practical applications to wearable devices, such as heavy power consumption. Here, we suggest an ultralow power (100 μW) sensor that collects all cardiopulmonary vital signs, including blood pressure, heart rate, and the respiration signal. The small and lightweight (2 g) sensor designed to be easily embedded in the flexible wristband generates an electromagnetically reactive near field to monitor the contraction and relaxation of the radial artery. The proposed ultralow power sensor measuring noninvasively continuous and accurate cardiopulmonary vital signs at once will be one of the most promising sensors for wearable devices to bring telehealth to our lives.
Dynamics of oral human papillomavirus infection in healthy population and head and neck cancer
Authors: Vani N. V. , Madhanagopal R. , Swaminathan R. , Ganesan T. S. 
Published: February 2023

AbstractThe recent increase in high‐risk human papillomavirus (HR‐HPV)‐associated oral and oropharyngeal cancers has gained considerable importance due to their distinct clinical and molecular characteristics. However, the natural history of oral HPV from acquisition to persistence and malignant transformation is still unclear. The global prevalence of oral HPV infection in healthy individuals ranges from 0.67% to 35%, while 31%–38.5% in head and neck cancer (HNC). The persistence rate of oral HR‐HPV infection is 5.5% –12.8% globally. India has the highest HNC burden due to apparent differences in predisposing factors compared with the West. The prevalence of oral HPV in healthy individuals and its contribution to HNC is less evident in Indian studies. HR‐HPV‐associated HNC in this region accounts for 26%, with an active infection in 8%–15% of these tumors. There is a lack of concordance in the expression of p16 as a surrogate marker for HPV detection in HNC because of differences in behavioral risk factors. Due to a lack of evidence, treatment de‐escalation cannot be implemented despite the improved outcome of HPV‐associated oropharyngeal cancers. This review critically analyzes the existing literature on the dynamics of oral HPV infection and HPV‐associated HNC, identifying potential avenues for future research. A better understanding of the oncogenic role of HR‐HPV in HNC will help to formulate novel therapeutic approaches and is expected to have a significant public health impact as preventive strategies can be implemented.
Race and socioeconomic status interact with HPV to influence survival disparities in oropharyngeal squamous cell carcinoma
Authors: Yan Emily Z. , Wahle Benjamin M. , Massa Sean T. , Zolkind Paul , Paniello Randal C. , Pipkorn Patrik , Jackson Ryan S. , Rich Jason T. , Puram Sidharth V. , Mazul Angela L. 
Published: February 2023

AbstractBackgroundHPV‐related oropharyngeal squamous cell carcinoma (OPSCC) is associated with a favorable prognosis, yet patients of color and low socioeconomic status (SES) continue to experience inferior outcomes. We aim to understand how the emergence of HPV has impacted race and SES survival disparities in OPSCC.MethodsA retrospective cohort of 18,362 OPSCC cases from 2010 to 2017 was assembled using the SEER (Surveillance, Epidemiology, and End Results) database. Cox proportional regression and Fine and Gray regression models were used to calculate hazard ratios (HRs) adjusting for race, SES, age, subsite, stage, and treatment.ResultsBlack patients had lower overall survival than patients of other races in HPV‐positive and HPV‐negative OPSCC (HR 1.31, 95% CI 1.13–1.53 and HR 1.23, 95% CI 1.09–1.39, respectively). Higher SES was associated with improved survival in all patients. Race had a diminished association with survival among high SES patients. Low SES Black patients had considerably worse survival than low SES patients of other races.ConclusionRace and SES interact variably across cohorts. High SES was protective of the negative effects of race, although there remains a disparity in outcomes among Black and non‐Black patients, even in high SES populations. The persistence of survival disparities suggests that the HPV epidemic has not improved outcomes equally across all demographic groups.
Group identification moderates the effect of historical trauma availability on historical trauma symptoms and conspiracy beliefs
Authors: Skrodzka Magdalena , Stefaniak Anna , Bilewicz Michał 
Published: February 2023

AbstractHistorical trauma may cast a shadow over the lives of subsequent generations of victimised groups. We examine the buffering role of victimised group identification on the association between the cognitive availability of historical trauma, historical trauma symptoms, and conspiracy beliefs. Two studies conducted in Poland (Study 1: Ukrainian minority, N = 92; Study 2: ethnic Poles; N = 227) revealed that among highly identified group members (compared to those with low levels of group identification), the relation between the cognitive availability of historical trauma and historical trauma symptoms was weaker. Study 2 additionally showed that the consequences of historical trauma are detectable among members of historically victimised groups, regardless of their own family history of victimisation, and that the cognitive availability of historical trauma correlates positively with conspiracy beliefs.
A severe case of PLOD1‐related kyphoscoliotic Ehlers–Danlos syndrome associated with several arterial and venous complications: A case report
Authors: Foy Malika , Métay Corinne , Frank Michael , Denarié Nicolas , Adham Salma , Billon Clarisse , Legrand Anne , Jeunemaitre Xavier , Gillas Fabrice , Gaudon Karen , De Mazancourt Philippe , Mekki Ahmed , Carlier Robert , Benistan Karelle 
Published: February 2023

AbstractKyphoscoliotic Ehlers–Danlos syndrome (kEDS) is a rare genetic disorder combining congenital hypotonia, congenital/early onset and progressive kyphoscoliosis, and generalized joint hypermobility. Vascular fragility is another characteristic of the disease rarely described. We report a severe case of kEDS‐PLOD1 with several vascular complications leading to difficulties in disease management.
In situ Reaction Monitoring in Photocatalytic Organic Synthesis
Authors: Madani Amiera , Pieber Bartholomäus 
Published: February 2023

AbstractVisible‐light photocatalysis provides numerous useful methodologies for synthetic organic chemistry. However, the mechanisms of these reactions are often not fully understood. Common mechanistic experiments mainly aim to characterize excited state properties of photocatalysts and their interaction with other species. Recently, in situ reaction monitoring using dedicated techniques was shown to be well‐suited for the identification of intermediates and to obtain kinetic insights, thereby providing more holistic pictures of the reactions of interest. This minireview surveys these technologies and discusses selected examples where reaction monitoring was used to elucidate the mechanism of photocatalytic reactions.
Structural Analysis of PtPd Core‐Shell Bimetallic Nanoparticles and their Enhanced Catalytic Performance for Ethanol Oxidation Reaction
Authors: Higareda América , Mares Fabian , Bahena Daniel , Esparza Rodrigo 
Published: February 2023

AbstractDirect alcohol fuel cells are claiming to be one of the primary clean power sources to attain a sustainable future. In the present study, PtPd core‐shell bimetallic nanoparticles (CSNPs) were synthesized by the polyol method. The shell was adjusted by adding an increased amount of Pd precursor on pre‐synthesized Pt nanoparticles. The morphology and atomic structure of the PtPd CSNPs were characterized by X‐ray diffraction and high‐resolution scanning transmission electron microscopy. PtPd CSNPs were successfully supported on Vulcan XC‐72 carbon and verified by scanning electron microscopy. The electrocatalysts were tested by cyclic voltammetry in an alkaline medium for the activity performance to ethanol oxidation reaction. The stability along with the presence of poisoning carbonaceous species was investigated by chronoamperometry and voltammetry cycles. Also, the cyclic durability was analysed. The results confirmed that the catalytic performance depends on the elemental composition of PtPd CSNPs, showing the optimum catalytic properties to PtPd (1 : 0.5)/C than commercial Pt/C.
Nickel‐Based Electrocatalysts for Hydrogen Oxidation Reaction Under Alkaline Electrolytes
Authors: Jin Yiming , Su Lixin , Jia Hongnan , Men Yana , Luo Wei 
Published: February 2023

AbstractDeveloping highly efficient and cost effective electrocatalysts towards hydrogen oxidation reaction under alkaline electrolyte is essential for the commercial application of anion exchange membrane fuel cells (AEMFCs). Nickel‐based materials showed great performance for alkaline HOR which have been regarded as promising alternatives for Pt‐group metals. In this review, several effective strategies which can successfully optimize the interaction with intermediates and promote the HOR kinetics of Ni under alkaline medium are discussed, including heteroatom doping, forming alloys and compounds, decorating with supports and constructing heterointerfaces. Meanwhile, based on the structural adjustment, the durabilities of Ni‐based materials are enhanced significantly. We believe this paper might provide guidance for future catalysts design and mechanism investigation for alkaline HOR.
An Ultralong Low‐Temperature Phosphorescent Pentagonal‐Prismatic Organometallic Cylinder Featuring Pentaphenylpyrrole‐N‐Heterocyclic Carbenes
Authors: Li Man , Li Yang , Li Xin , Wang Fang , Han Ying‐Feng 
Published: February 2023

Comprehensive SummaryA pentagonal‐prismatic cylinder [Ag5(L)2](PF6)5 obtained from the pentaphenylpyrrole‐bridged pentaimidazolium salt H5‐L(PF6)5 and AgI ions was determined by X‐ray diffraction analyses. The target organometallic cylinder not only exhibited enhanced fluorescence emission in dilute solution at room temperature but also showed an improved phosphorescence ratio compared with the free precursor and maintained a long lifetime (1.39 s) in the solid state at 77 K. Furthermore, the experimental results and DFT calculations confirmed that the formation of the organometallic cylinder promoted intersystem crossing. Meanwhile, the frontier orbitals of [Ag5(L)2](PF6)5 showed the main contribution of building block PPP as the luminescence source of [Ag5(L)2](PF6)5 by a modest heavy‐atom effect. These results provide a strategy for constructing enhanced phosphorescent emission and long lifetime organometallic supramolecular phosphorescent materials.
Mechanical influence of periacetabular osteotomy on late total hip arthroplasty
Authors: Ma Yunqing , Chen Songhao , Chen Duanduan 
Published: February 2023

AbstractPeriacetabular osteotomy (PAO) is an effective technique to treat symptomatic hip dysplasia. However, following PAO, some patients still experience persistent pain or development of hip arthritis, requiring total hip arthroplasty (THA). Issues such as whether patients with PAO are necessarily at increased risk of post‐THA complications and revision of the prosthesis remain debatable. The purpose of this study was to evaluate the biomechanical influence of PAO on the acetabulum after THA by finite element analysis. Eight patients with developmental dysplasia of the hip (DDH) diagnosed in the Fourth Medical Center of the PLA General Hospital were enrolled in this research. Patient‐specific hip joint models were reconstructed from computed tomography scans, and the hip prosthesises, were established via computer‐aided design (CAD) modeling technology. The finite element analysis was conducted to compare the surface and internal stress through the process mapping of the model due to the THA. Compared with the THA after PAO, the position of the high‐stress area of the acetabular fossa of patients without PAO decreased, and the high‐stress area developed toward the lower edge of the acetabulum. Although the high‐stress area of the suprapubic branch did not change significantly, the peak stress was higher (t = .00237). The analysis of the section plane showed that the high‐stress area of cancellous bone had a large distribution. The acetabular size and vertical distance of rotation center (VDRC) were significantly correlated with the maximum postoperative acetabular equivalent stress (p = .011, p = .001). In the Post group, both the horizontal distance of rotation center (HDRC) and A‐ASA were significantly correlated with postoperative maximal acetabular equivalent stress, with a significance of 0.014 and 0.035, respectively. The risk of postoperative prosthetic revision following THA is not increased by PAO, although the risk of postoperative suprapubic branch fracture is increased.
Optimal design of VHF resonant boost converter considering the nonlinear characteristic of parasitic capacitance
Authors: Zeng Libin , Chen Yanfeng , Zhang Bo , Qiu Dongyuan 
Published: February 2023

SummaryVery‐high‐frequency (VHF) resonant converters have the advantages of small volume, light weight, and high power density. However, under the operating frequency of tens of megahertz, the nonlinear characteristics of the power semiconductor devices intrinsic capacitances will affect the analysis accuracy of VHF converters and increase the difficulty of parameter design of these converters. Thus, this paper proposes a method to obtain the equivalent capacitances of power semiconductor devices. Taking the VHF resonant boost converter as an example, the process of obtaining the equivalent capacitances of power semiconductor devices is elaborated first. And then a prototype with operating frequency 17.30 MHz, input voltage 3–6 V, and output voltage 9–18 V is built to verify the feasibility and effectiveness of the proposed method.
A low settling time switching scheme for SAR ADCs with reset‐free regenerative comparator
Authors: Pahlavanzadeh Hadi , Karami Mohammad Azim 
Published: February 2023

SummaryThis paper presents an energy‐efficient fully differential switching scheme for successive approximation register (SAR) analog‐to‐digital converters (ADCs). During the sampling phase, the top and bottom plates of all capacitors except most significant bit (MSB) capacitors are grounded in digital‐to‐analog converter (DAC) arrays. The input signals are bottom plate sampled on MSB capacitors. This technique can reduce the settling time by more than 87.5% in comparison with the conventional switching scheme. Furthermore, a novel reset‐free regenerative comparator is unveiled in this paper. The proposed comparator is armed to amplify its inputs both during the reset and evaluation phases. In comparison with a conventional single‐ended comparator, the proposed comparator can reduce power consumption above 90% for the almost same input‐referred offset voltage. The proposed scheme is designed with a resolution of 8‐bit and a sampling rate of 90 MS/s in a standard 65‐nm CMOS technology. The simulation results certify that the ADC dissipates 363‐μW power with a 1.2‐V supply voltage and achieves a 7.13 effective number of bits (ENOBs), yielding a 28.8 fJ/conversion step Nyquist rate Walden FOM.