bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet Rich Plasma Loaded Multifunctional Hydrogel Accelerates Diabetic Wound Healing via Regulating the Continuously Abnormal Microenvironments
Authors: Xu Kui , Deng Sijie , Zhu Yabin , Yang Wei , Chen Weizhen , Huang Liang , Zhang Chi , Li Ming , Ao Lijiao , Jiang Yibo , Wang Xiangyu , Zhang Qiqing 
Published: July 2023

AbstractContinuous oxidative stress and cellular dysfunction caused by hyperglycemia are distinguishing features of diabetic wounds. It has been a great challenge to develop a smart dressing that can accelerate diabetic wound healing through regulating abnormal microenvironments. In this study, a platelet rich plasma (PRP) loaded multifunctional hydrogel with reactive oxygen species (ROS) and glucose dual‐responsive property is reported. It can be conveniently prepared with PRP, dopamine (DA) grafted alginate (Alg‐DA), and 6‐aminobenzo[c][1,2]oxaborol‐1(3H)‐ol (ABO) conjugated hyaluronic acid (HA‐ABO) through ionic crosslinks, hydrogen‐bond interactions, and boronate ester bonds. The hydrogel possesses injectability, moldability, tissue adhesion, self‐healing, low hemolysis, and hemostasis performances. Its excellent antioxidant property can create a low oxidative stress microenvironment for other biological events. Under an oxidative stress and/or hyperglycemia state, the hydrogel can degrade at an accelerated rate to release a variety of cytokines derived from activated blood platelets. The result is a series of positive changes that are favorable for diabetic wound healing, including fast anti‐inflammation, activated macrophage polarization toward M2 phenotype, promoted migration and proliferation of fibroblasts, as well as expedited angiogenesis. This work provides an efficient strategy for chronic diabetic wound management and offers an alternative for developing a new‐type PRP‐based bioactive wound dressing.
Engineered Nanomaterials to Potentiate CRISPR/Cas9 Gene Editing for Cancer Therapy
Authors: Yi Ke , Kong Huimin , Lao Yeh‐Hsing , Li Di , Mintz Rachel L. , Fang Tianxu , Chen Guojun , Tao Yu , Li Mingqiang , Ding Jianxun 
Published: July 2023

AbstractClustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple tumor‐associated genes and engineering immune cells to treat cancers. Currently, most gene‐editing strategies rely on viral delivery; yet, while being efficient, many limitations, mainly from safety and packaging capacity considerations, hinder the use of viral CRISPR vectors in cancer therapy. In contrast, recent advances in non‐viral CRISPR/Cas9 nanoformulations have paved the way for better cancer gene editing, as these nanoformulations can be engineered to improve safety, efficiency, and specificity through optimizing the packaging capacity, pharmacokinetics, and targetability. In this review, the advance in non‐viral CRISPR delivery is highlighted, and there is a discussion on how these approaches can be potentially used to treat cancers in addressing the aforementioned limitations, followed by the perspectives in designing a proper CRISPR/Cas9‐based cancer nanomedicine system with translational potential.
Hierarchies in Visual Pathway: Functions and Inspired Artificial Vision
Authors: Zhu Shirui , Xie Tao , Lv Ziyu , Leng Yan‐Bing , Zhang Yu‐Qi , Xu Runze , Qin Jingrun , Zhou Ye , Roy Vellaisamy A. L. , Han Su‐Ting 
Published: July 2023

AbstractThe development of artificial intelligence has posed a challenge to machine vision based on conventional complementary metal‐oxide semiconductor (CMOS) circuits owing to its high latency and inefficient power consumption originating from the data shuffling between memory and computation units. Gaining more insights into the function of every part of the visual pathway for visual perception can bring the capabilities of machine vision in terms of robustness and generality. Hardware acceleration of more energy‐efficient and biorealistic artificial vision highly necessitates neuromorphic devices and circuits that are able to mimic the function of each part of the visual pathway. In this paper, we review the structure and function of the entire class of visual neurons from the retina to the primate visual cortex within reach (Chapter 2) are reviewed. Based on the extraction of biological principles, the recent hardware‐implemented visual neurons located in different parts of the visual pathway are discussed in detail in Chapters 3 and 4. Furthermore, valuable applications of inspired artificial vision in different scenarios (Chapter 5) are provided. The functional description of the visual pathway and its inspired neuromorphic devices/circuits are expected to provide valuable insights for the design of next‐generation artificial visual perception systems.
Polyhedron‐Like Biomaterials for Innervated and Vascularized Bone Regeneration
Authors: Zhang Hongjian , Zhang Meng , Zhai Dong , Qin Chen , Wang Yufeng , Ma Jingge , Zhuang Hui , Shi Zhe , Wang Liang , Wu Chengtie 
Published: July 2023

AbstractNeural‐vascular networks are densely distributed through periosteum, cortical bone, and cancellous bone, which is of great significance for bone regeneration and remodeling. Although significant progress has been made in bone tissue engineering, ineffective bone regeneration, and delayed osteointegration still remains an issue due to the ignorance of intrabony nerves and blood vessels. Herein, inspired by space‐filling polyhedra with open architectures, polyhedron‐like scaffolds with spatial topologies are prepared via 3D‐printing technology to mimic the meshwork structure of cancellous bone. Benefiting from its spatial topologies, polyhedron‐like scaffolds greatly promoted the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) via activating PI3K‐Akt signals, and exhibiting satisfactory performance on angiogenesis and neurogenesis. Computational fluid dynamic (CFD) simulation elucidates that polyhedron‐like scaffolds have a relatively lower area‐weighted average static pressure, which is beneficial to osteogenesis. Furthermore, in vivo experiments further demonstrate that polyhedron‐like scaffolds obviously promote bone formation and osteointegration, as well as inducing vascularization and ingrowth of nerves, leading to innervated and vascularized bone regeneration. Taken together, this work offers a promising approach for fabricating multifunctional scaffolds without additional exogenous seeding cells and growth factors, which holds great potential for functional tissue regeneration and further clinical translation.
Spin‐Polarization Strategy for Enhanced Acidic Oxygen Evolution Activity
Authors: Li Ling , Zhou Jing , Wang Xiao , Gracia Jose , Valvidares Manuel , Ke Jia , Fang Miaomiao , Shen Chenqi , Chen Jin‐Ming , Chang Yu‐Chung , Pao Chih‐Wen , Hsu Su‐Yang , Lee Jyh‐Fu , Ruotolo Antonio , Chin Yiying , Hu Zhiwei , Huang Xiaoqing , Shao Qi 
Published: July 2023

AbstractSpin‐polarization is known as a promising way to promote the anodic oxygen evolution reaction (OER), since the intermediates and products endow spin‐dependent behaviors, yet it is rarely reported for ferromagnetic catalysts toward acidic OER practically used in industry. Herein, the first spin‐polarization‐mediated strategy is reported to create a net ferromagnetic moment in antiferromagnetic RuO2 via dilute manganese (Mn2+) (S = 5/2) doping for enhancing OER activity in acidic electrolyte. Element‐selective X‐ray magnetic circular dichroism reveals the ferromagnetic coupling between Mn and Ru ions, fulfilling the Goodenough–Kanamori rule. The ferromagnetism behavior at room temperature can be well interpreted by first principles calculations as the interaction between the Mn2+ impurity and Ru ions. Indeed, Mn‐RuO2 nanoflakes exhibit a strongly magnetic field enhanced OER activity, with the lowest overpotential of 143 mV at 10 mA cmgeo−2 and negligible activity decay in 480 h stability (vs 200 mV/195 h without magnetic field) as known for magnetic effects in the literature. The intrinsic turnover frequency is also improved to reach 5.5 s−1 at 1.45 VRHE. This work highlights an important avenue of spin‐engineering strategy for designing efficient acidic oxygen evolution catalysts.
High‐Yield Synthesis of Sodium Chlorides of Unconventional Stoichiometries
Authors: Xia Xinming , Huang Yingying , Peng Bingquan , Wang Tao , Yi Ruobing , Zhao Yimin , Jiang Jie , Dai Fangfang , Fan Yan , Li Pei , Tu Yusong , Zhang Lei , Fang Haiping , Chen Liang 
Published: July 2023

AbstractAbnormal salt crystals with unconventional stoichiometries, such as Na2Cl, Na3Cl, K2Cl, and CaCl crystals that have been explored in reduced graphene oxide membranes (rGOMs) or diamond anvil cells, hold great promise in applications due to their unique electronic, magnetic, and optical properties predicted in theory. However, the low content of these crystals, only <1% in rGOM, limits their research interest and utility in applications. Here, a high‐yield synthesis of 2D abnormal crystals with unconventional stoichiometries is reported, which is achieved by applying negative potential on rGOM. A more than tenfold increase in the abnormal Na2Cl crystals is obtained using a potential of −0.6 V, resulting in an atomic content of 13.4 ± 4.7% for Na on rGOM. Direct observations by transmission electron microscopy and piezoresponse force microscopy demonstrates a unique piezoelectric behavior arising from 2D Na2Cl crystals with square structure. The output voltage increases from 0 to ≈180 mV in the broad 0–150° bending angle regime, which meets the voltage requirement of most nanodevices in realistic applications. Density functional theory calculations reveal that the applied negative potential of the graphene surface can strengthen the effect of the Na+–π interaction and reduce the electrostatic repulsion between cations, making more Na2Cl crystals formed.
An H2O‐Initiated Crosslinking Strategy for Ultrafine‐Nanoclusters‐Reinforced High‐Toughness Polymer‐In‐Plasticizer Solid Electrolyte
Authors: Bao Wenda , Zhang Yue , Cao Lei , Jiang Yilan , Zhang Hui , Zhang Nian , Liu Ying , Yan Pu , Wang Xingzhi , Liu Yixiao , Li Haoyuan , Zhao Yingbo , Xie Jin 
Published: July 2023

AbstractIncorporating plasticizers is an effective way to facilitate conduction of ions in solid polymer electrolytes (SPEs). However, this conductivity enhancement often comes at the cost of reduced mechanical properties, which can make the electrolyte membrane more difficult to process and increase safety hazards. Here, a novel crosslinking strategy, wherein metal‐alkoxy‐terminated polymers can be crosslinked by precisely controlling the content of H2O as an initiator, is proposed. As a proof‐of‐concept, trimethylaluminum (TMA)‐functionalized poly(ethylene oxide) (PEO) is used to demonstrate that ultrafine Al–O nanoclusters can serve as nodes to crosslink PEO chains with a wide range of molecular weights from 10 000 to 8 000 000 g mol−1. The crosslinked polymer network can incorporate a high concentration of plasticizers, with a total weight percentage over 75%, while still maintaining excellent stretchability (4640%) and toughness (3.87 × 104 kJ m−3). The resulting electrolyte demonstrates high ionic conductivity (1.41 mS cm−1), low interfacial resistance toward Li metal (48.1 Ω cm2), and a wide electrochemical window (>4.8 V vs Li+/Li) at 30 °C. Furthermore, the LiFePO4/Li battery shows stable cycle performance with a capacity retention of 98.6% (146.3 mAh g−1) over 1000 cycles at 1C (1C = 170 mAh g−1) at 30 °C.
A General Strategy for Developing Ultrasensitive “Transistor‐Like” Thermochromic Fluorescent Materials for Multilevel Information Encryption
Authors: Zhang Ke , Zhou Xiaobo , Li Shijie , Zhao Lingfeng , Hu Wenqi , Cai Aiting , Zeng Yuhan , Wang Qi , Wu Mingmin , Li Guo , Liu Jinxia , Ji Haiwei , Qin Yuling , Wu Li 
Published: July 2023

AbstractThermochromic fluorescent materials (TFMs) exhibit great potential in information encryption applications but are limited by low thermosensitivity, poor color tunability, and a wide temperature‐responsive range. Herein, a novel strategy for constructing highly sensitive TFMs with tunable emission (450–650 nm) toward multilevel information encryption is proposed, which employs polarity‐sensitive fluorophores with donor–acceptor–donor (D–A–D) type structures as emitters and long‐chain alkanes as thermosensitive loading matrixes. The structure–function relationships between the performance of TFMs and the structures of both fluorescent emitters and phase‐change molecules are systematically studied. Benefiting from the above design, the obtained TFMs exhibit over 9500‐fold fluorescence enhancement toward the temperature change, as well as ultrahigh relative temperature sensitivity up to 80% K−1, which are first confirmed. Thanks to the superior transducing performance, the above‐prepared TFMs can be further developed as information‐storage platforms within a relatively narrow interval of temperature variation, including temperature‐dominated multicolored information display and multilevel information encryption. This work will not only provide a novel perspective for designing superior TFMs for information encryption but also bring inspiration to the design and preparation of other response‐switching‐type fluorescent probes with ultrahigh conversion efficiency.
An Overview on 3D Printing of Structured Porous Materials and Their Applications
Authors: Gao Yuanyuan , Lalevée Jacques , Simon‐Masseron Angélique 
Published: July 2023

AbstractPorous materials play an essential role in chemical processes such as catalysis, adsorption, and in emerging technologies for electronic materials, light harvesting, and energy transfer. By far, zeolites have contributed most to industrial development. Other porous solid such as activated carbon, metal–organic frameworks, covalent organic frameworks, and porous coordination polymers also have been studied by researchers in the past two decades. The use of porous solids is set to grow in the future, and so is the need to fabricate them into more complex and diverse geometries for a variety of applications. Additive manufacturing, also known as 3D printing, has provided the possibility to shape the materials into desired forms, which offers many advantages over their traditional configurations. Structured catalysts, for example, can help to overcome the drawbacks of conventional packed catalyst bed‐like mass or heat transfer limitations and high pressure drop. This review focuses on the latest advances as well as the current challenges in 3D printing of the porous solids. This article aims to contribute to the shape engineering of porous solids and provide a better understanding of their formulations, structures, techniques, properties, and applications.
CsPbBr3@Glass@SiO2 Composite Materials with Ultrahigh Water Resistance and Thermal Reversibility of Photoluminescence
Authors: Liu Ching , Huang Wen‐Tse , Li Juqing , Lee Yu‐Chun , Tsai Tzong‐Liang , Shen Fang‐Chun , Wu Wen‐Wei , Liu Ru‐Shi , Zhang Xuejie 
Published: July 2023

AbstractPerovskite quantum dots usually possess excellent optical properties, such as high color purity, high photoluminescence quantum yield, and tunable emission wavelength. However, their relatively low stability against heat, water, oxygen, and light hinders their practical applications in the field of optoelectronic devices. Herein, melt‐quenching and heat treatment crystallization methods are used to fabricate the CsPbBr3@glass. Atomic layer deposition and the sol–gel method are applied to encapsulate the CsPbBr3@glass with a dense SiO2 layer and hydrophobic SiO2 layer, respectively, to further improve the water resistance, thermal reversibility of photoluminescence, and photostability. The CsPbBr3@glass@ASG can be synthesized with the triple layer encapsulation of the glass matrix, dense SiO2 layer, and hydrophobic SiO2 layer. During the water resistance test for seven weeks, CsPbBr3@glass@ASG can preserve ≈100% of initial PL intensity. Similarly, it can preserve ≈100% of PL intensity after five continuous heating–cooling cycles between 30 and 100 °C. In addition, the internal and external quantum efficiencies of CsPbBr3@glass@ASG can still be maintained at 42.0% and 33.7%, respectively. Results indicate that CsPbBr3@glass@ASG can provide a balance between optical properties and extrinsic stability successfully, thereby becoming a potential candidate material for practical applications related to optoelectronic devices in the future.
Facile Microwave Synthesis of Efficient Green Emissive Carbon Dots Powder and Their Application in Visible Light Communication and White Light Emitting Devices
Authors: Guo Junlu , Li Yanzhe , Shan Xinyi , Wang Deyin , Tian Pengfei , Wang Yuhua 
Published: July 2023

AbstractHighly green emissive solid‐state carbon dots (CDs) with photoluminescence quantum efficiency of 58% are prepared through a rapid microwave assisted heating method. Due to the spatial confinement from the biuret crystal matrix, aggregation among CDs is effectively suppressed, thus allowing the CDs to give efficient emission in the solid‐state. The CDs show excitation independent emission and mono‐exponential decay characteristics with a nearly constant lifetime of ≈13 ns upon varying the detected emissions, indicating the presence of a single type of emissive state in the CDs. Due to their high quantum efficiency and short lifetime, the obtained CDs are applied as the color conversion layer of a near‐ultraviolet micro light‐emitting diode (µLED) chip (405 nm) for visible light communication, achieving a modulation bandwidth of 165 MHz, which is much higher than the bandwidth of the conventional combination of Ce3+‐doped yttrium aluminum garnet phosphor with GaN LED. Moreover, the green emitting solid‐state CDs are applied to fabricate a prototype white LED device, which exhibits good lighting suitability with a color rendering index of 90.6 and a Commission Internationale de L'Eclairage chromaticity coordinates of (0.327, 0.332).
Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance
Authors: Zhu Xudong , Li Shenglong 
Published: July 2023

AbstractIn recent years, the incidence of gastrointestinal cancers is increasing, particularly in the younger population. Effective treatment is crucial for improving patients’ survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role in the growth and development of organisms. It is also critical for maintaining tissue and organ homeostasis and takes part in multiple pathological processes. In addition to apoptosis, there are other types of programmed cell death, such as ferroptosis, necroptosis, and pyroptosis, which can induce severe inflammatory responses. Notably, besides apoptosis, ferroptosis, necroptosis, and pyroptosis also contribute to the occurrence and development of gastrointestinal cancers. This review aims to provide a comprehensive summary on the biological roles and molecular mechanisms of ferroptosis, necroptosis, and pyroptosis, as well as their regulators in gastrointestinal cancers and hope to open up new paths for tumor targeted therapy in the near future.
Nanoscale Quantized Oscillations in Thin‐Film Growth Greatly Enhance Transconductance in Organic Transistors
Authors: Drakopoulou Sofia , Murgia Mauro , Albonetti Cristiano , Benaglia Simone , Borgatti Francesco , Di Lauro Michele , Bianchi Michele , Greco Pierpaolo , Papo David , Garcia Ricardo , Alessandrini Andrea , Biscarini Fabio 
Published: July 2023

AbstractA growth mode of pentacene thin films deposited by high vacuum sublimation where the morphology versus thicknessh“rings” back and forth between rough 3D films with pyramid islands and smooth 2D films with ziqqurat islands is discovered. The roughnessσversushexhibits seamless coherent oscillations whose amplitude and wavelength increase as integer multiples of 1.5 ML thickness. The quantized oscillations are reconducted to dynamic wetting/dewetting transitions involving the upper layers of pentacene film. Importantly, the transconductance of organic field effect transistors, either in solid state or electrolyte‐gated, exhibits antiphase oscillations with one‐decade swing. Charge mobilities in the wetting regime reach 0.1 cm2V−1s−1, in line with high‐end values reported for thin‐film pentacene transistors. Controlling this growth mode enables the limitations of charge transport imposed by the roughening transition to be overcome, a universal feature of high vacuum growth to date.
Dimensional Strategies for Bridging the Research Gap between Lab‐Scale and Potentially Practical All‐Solid‐State Batteries: The Role of Sulfide Solid Electrolyte Films
Authors: Song Yong Bae , Baeck Ki Heon , Kwak Hiram , Lim Haechannara , Jung Yoon Seok 
Published: July 2023

AbstractThe absence of liquid components in all‐solid‐state batteries (ASSBs) based on sulfide solid electrolytes (SSEs) significantly impacts manufacturing processes and performance, particularly concerning mechanical properties and evolution. SSE films play vital roles in this context. This review provides a comprehensive analysis of SSE film design strategies, emphasizing their significance in the cell assembly and operation of practical ASSBs. Essential SSE film components are examined, including SSEs, binders, and scaffold or substrate materials, and key characteristics related to ASSB assembly and operation are addressed, such as conduction properties, electrochemical stability, and mechanical properties. Various SSE films fabricated using different binders and scaffold or substrate materials are explored through slurry‐casting or solvent‐free methods, and ASSBs employing SSE films with diverse form factors and components are presented, emphasizing their ability to operate under low‐pressure conditions. Additionally, the importance of establishing test protocols for assessing SSE film performance metrics is highlighted and strategies for enabling Li metal anodes are introduced. By deepening the understanding of the electrochemo‐mechanical phenomena and engineering processes in ASSBs, it is anticipated that the gap between lab‐scale research and practical goals can be bridged through design strategies that leverage the hybridization of various compositions and the immiscible nature of solid‐state materials.
Crystal‐Facet Manipulation and Interface Regulation via TMP‐Modulated Solid Polymer Electrolytes toward High‐Performance Zn Metal Batteries
Authors: Qiu Bin , Liang Kaiyuan , Huang Wei , Zhang Guoqiang , He Chuanxin , Zhang Peixin , Mi Hongwei 
Published: July 2023

AbstractRechargeable Zn‐ion batteries (ZIBs), prospective candidates for broad‐scale energy storage, still encounter many challenges such as hydrogen evolution corrosion, Zn dendrite growth, and capacity fading. Therefore, one specific strategy for tuning the internal structure of solid polymer electrolytes (SPEs) via organic additives is proposed to address these urgent bottlenecks simultaneously. With trimethyl phosphate (TMP) addition, the coordination environment of Zn2+in SPEs is altered and exists as Zn2+(TMP)x(OTf−)ycoordinated molecules. Meanwhile, the strong interaction between TMP and Zn enables the preferential growth of Zn(002) planes during electrodeposition, which is proved based on first‐principles calculations, finite element simulations, and multiple in situ characterizations. Such excellent interfacial engineering in situ forms the solid electrolyte interface rich in Zn3(PO4)2fast ion conductor and guarantees one ultra‐long cycle life for more than 6000 h in a Zn|Zn symmetric cell at 0.1 mA cm−2. Moreover, the universality of TMP‐modified SPEs shows 1000 times stable cycling of VO2(B)|Zn full cells at 1 A g−1under 0 °C with 95.24% capacity retention, which satisfies potential applications of wide‐ranging energy storage based on solid‐state ZIBs.