bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-R06-8: AMLODIPINE WELL RESPONDED TO HYPERTENSION ALONG WITH HEADACHE IN PATIENT UNDERGOING WHOLE BRAIN RADIATION THERAPY (CASE REPORT)
Authors: Ozeki Rie , Sai Hyonmi , Iijima Kotaro , Watanabe Junichiro , Saito Mitsue 
Published: January 2023

Objective:
According to the current treatment guideline for breast cancer issued by Japanese Breast Cancer Society, surgery or stereotactic radiotherapy is recommended for patients with solitary brain metastasis (BM), while whole brain radiotherapy (WBRT) is recommended for patients with multiple BMs. Common treatment-related toxicities during radiotherapy include fatigue, drowsiness, alopecia, headache, nausea, or vomiting, however, elevation of blood pressure has not been reported. We report a case of headache due to high blood pressure during WBRT.

Case:
A 5X-year female was diagnosed as HER2-positive operable left breast cancer underwent radical mastectomy followed by adjuvant chemotherapy including one-year trastuzumab. Three years after surgery she was diagnosed as having cancerous pleurisy, cancerous pericarditis, and multiple bone metastases. The patient received 6 cycles of trastuzumab, pertuzumab and docetaxel and 5 cycles of trastuzumab and pertuzumab. She noticed chronic headache and magnetic resonance imaging of the brain showed metastases to the right frontal lobe and left cerebellum. She was hospitalized and underwent WBRT. She received corticosteroid and glycerin-fructose injection to reduce the intracranial pressure (ICP) along with WBRT. On the 10th day of hospitalization, she complained severe headache with numerical rating scale (NRS) of 6. While an analgesic was not effective, elevated blood pressure (160/80 mmHg) since admission was suspected as a cause of headache. High-dose amlodipine at the dose of 10 mg was prescribed and the patient well responded to amlodipine as blood pressure of 130/70 mmHg and headache was relieved.

Discussion:
In patients with BMs, headache is common symptom due to elevate ICP or leptomeningeal dissemination. However, analgesic and ICP relief therapy did not work in this case. Guidelines for the management of hypertension 2019 (JSH 2019) define hypertension as 140/90 mmHg or higher, and in low-risk cases without underlying disease, non-pharmacologic therapy is recommended. Ultimately, the use of a calcium channel blockers resulted in a decrease in blood pressure and improvement in headache. It is possible that the headache was caused by increased sympathetic nerve activity via ischemia in the brainstem due to increased ICP, such as in brain tumors, which can lead to hypertension. Amlodipine is recommended for patients with chronic cerebrovascular disease because of its long acting and slow onset of effect, as well as its ability to protect organ blood flow.

Conclusion:
This case revealed hypertension may be the cause of headaches during WBRT, in which case amlodipine was effective.
Application of a Thoracic CT Decision Rule in the Evaluation of Injured Children: A Quality Improvement Initiative
Authors: Downie Katie , McIntire Alicia , Tobias Joseph , Krishnaswami Sanjay , Jafri Mubeen 
Published: January 2023

Background:
Differences in injury patterns in children suggest that life-threatening chest injuries are rare. Radiation exposure from computed tomography increases cancer risk in children. Two large retrospective pediatric studies have demonstrated that thoracic computed tomography can be reserved for patients based on mechanism of injury and abnormal findings on chest radiography.

Objective:
Implement a decision rule to guide utilization of thoracic computed tomography in the evaluation of pediatric blunt trauma, limiting risk of unnecessary radiation exposure and clinically significant missed injuries.

Methods:
A protocol for thoracic computed tomography utilization in pediatric blunt trauma was implemented using a Plan-Do-Study-Act cycle at our Level I pediatric trauma center, reserving thoracic computed tomography for patients with (1) mediastinal widening on chest radiography or (2) vehicle-related mechanism and abnormal chest radiography. We modified our resuscitation order set to limit default imaging bundles. The medical record and trauma registry data were reviewed for all pediatric blunt trauma patients (younger than 18 years) over a 30-month study period before and after protocol implementation (May 2017 to July 2018 and February 2019 to April 2020), allowing for a 6-month implementation period (August 2018 to January 2019).

Results:
During the study period, 1,056 blunt trauma patients were evaluated with a median (range) Injury Severity Score of 5 (0–58). There were no significant demographic differences between patients before and after protocol implementation. Thoracic computed tomography utilization significantly decreased after implementation of the protocol (26.4% [129/488] to 12.7% [72/568; p < .05]), with no increase in clinically significant missed injuries. Protocol compliance was 88%.

Conclusions:
Application of decision rules can safely limit ionizing radiation in injured children. Further limitations to thoracic computed tomography utilization may be safe and warrant continued study due to the rarity of significant injuries.
Impact of COVID-19 on U.S. Hospital-Based Injury Prevention Professionals: A National Survey
Authors: Edwards Courtney , Arabian Sandra Strack , Colburn-Hargis Paige , Duchossois Gina , Adams Christy 
Published: January 2023

Background:
COVID-19 challenged U.S. trauma centers to grapple with demands for expanded services with finite resources while also experiencing a concurrent increase in violent injuries.

Objective:
The purpose of this study was to describe the impact of COVID-19 on the roles and duties of U.S. hospital-based injury prevention professionals.

Methods:
This descriptive cross-sectional survey study of hospital-based injury prevention professionals was conducted between June 2021 and August 2021. Participants were recruited from six organizational members of the national Trauma Prevention Coalition, including the American Trauma Society, Emergency Nurses Association, Injury Free Coalition for Kids, Safe States Alliance, Society for Trauma Nurses, and Trauma Center Association of America. Results were analyzed using descriptive and inferential statistics.

Results:
A total of 216 participants affiliated with 227 trauma centers responded. The following changes were reported during 2020: change in injury prevention position (range = 31%–88%); change in duties (range = 92%–100%); and change to hospital-based injury prevention programs (range = 75%–100%). Sixty-one (43%) single-center participants with a registered nurse license were reassigned to clinical duties compared with six (10%) nonlicensed participants (OR = 5.6; 95% CI [1.96, 13.57]; p < .001). Injury prevention programs at adult-only and combined adult and pediatric trauma centers had higher odds of suspension than pediatric-only trauma centers (OR = 3.6; 95% CI [1.26, 10.65]; p < .017).

Conclusion:
The COVID-19 response exposed the persistent inequity and limited prioritization of injury prevention programming as a key deliverable for trauma centers.
Therapeutic efficacy of Chinese patent medicine containing pyrite for fractures: A protocol for systematic review and meta-analysis
Authors: Choi Su Hyeon , Nam Eun-Young , Hwang Ji Hye 
Published: January 2023

Background:
Fractures are a condition in which bone continuity is lost or linear deformity occurs. They are a worldwide public health problem and a significant economic burden. The purpose of this study is to analyze the efficacy of Chinese patent medicine containing pyrite (CPMP) through systematic review and meta-analysis of fracture clinical data.

Methods:
A literature search will be carried out from the inception of CPMP studies to September 2022 using EMBASE, PubMed, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, Korean Studies Information Service System, National Digital Science Library, and Oriental Medicine Advanced Searching Integrated System. Randomized controlled trials which include CPMP will be considered as eligible regardless of the type of fracture. After screening the literature, extracting the data, and assessing the risk of bias from the included studies, a meta-analysis will be performed using Review Manager version 5.4.

Results:
This study is expected to provide evidence for the efficacy and safety of CPMP for fractures.

Conclusion:
Our findings will provide evidence to determine whether CPMP can be an effective intervention for patients with fractures, which would expand the possible treatment options.
A Novel Way to Objectively Review Emerging Rehabilitation Technologies
Authors: Cook Hayley , McLaughlin Kevin H. , Johnson Ken , Raghavan Preeti 
Published: January 2023

Abstract
Technology-enhanced rehabilitation can improve access to training activities in multiple care delivery settings and may improve patient outcomes. However, the rate at which rehabilitation technology is being developed makes it difficult for healthcare systems to keep pace with the volume of products emerging in this space. Formal processes are needed to help healthcare systems review products as they emerge and to determine whether they should be incorporated into clinical practice. Here, we describe an approach to reviewing emerging rehabilitation technologies as performed by the Center for Emerging Rehabilitation Technology at our institution. Developed using an iterative approach, the rehabilitation technology review process used by the Center for Emerging Rehabilitation Technology team classifies technologies into the following three categories: (1) for clinical deployment, (2) for innovation in product development/product-market fit testing, and (3) for research, for example, a sponsored clinical trial. We describe the processes used to evaluate, categorize, investigate, and integrate rehabilitation technology, share our experience with the review process, and make recommendations for other institutions who may wish to implement rehabilitation technology into clinical practice.
Quantitative Assessment of Injectable Medication Delivery Practices
Authors: Aggerwal Salena , Minerbi Amir , Beliveau Lt(N) Peter , Meredith LCol Sean , Lalonde MCpl Sasha , Laurin Erica , Gupta Gaurav 
Published: January 2023

AbstractBackgroundWhile medical advances for in-hospital care rapidly evolve, a mainstay of effective pre-hospital care remains the ability to treat medical emergencies such as anaphylaxis, overdosing, and/or uncontrolled bleeding through rapid administration of appropriate medication. Therefore, investigators looked at various injection methods and their possible utility in medical emergencies.Method30 participants were asked to inject ‘medication’ that mimicked three different methods of injection: 1) autoinjectors, 2) prefilled syringes, and 3) traditional standard syringes using clinical scenarios. Three variables that were measured in the study were: the time required to complete the injection, the perceived difficulties, and the participant’s performance errors.ResultsThe perceived difficulty and injection time for the autoinjector device were statistically significantly lower compared to prefilled syringes and standard syringes. No significant difference in errors were seen between platforms.DiscussionTo our knowledge, this is the first study to quantify the gain of efficiency when comparing autoinjectors to other methods of medication administration, like prefilled syringes or drawing medication from vials for administration. The clinical implications of the noted differences are not clear at this time. Many potential limitations exist, including the size of the study, the use of non-clinical participants, the immediate use of platforms after training, and the lack of applied stress in the environment.ConclusionThis study compares autoinjectors to other methods of medication administration; prefilled syringes and standard syringes. Further study in larger datasets with clinicians and/or military personnel is required to compare these platforms in various environments. The outcome of this project provides insights into the relative efficiencies of treating medical emergencies such as anaphylaxis, overdosing, and/or uncontrolled bleeding.
Virtual fun in a virtual workplace: employee socialization for “work from home”
Authors: Ghosh Koustab , Sinha Sweta , Sharma Dheeraj 
Published: January 2023

PurposeThis paper introduces “virtual fun at the virtual workplace” and conceptualizes its impact on virtual socialization and the formation of virtual professional ties. The conceptual model also recognizes the moderation of a few variables: “awareness of being observed,” “diversity in the virtual workplace” and “virtual impression management.”Design/methodology/approachThe paper takes a theoretical approach to develop a conceptual framework of virtual fun in the virtual workplace, drawing on social exchange theory (SET) and social network theory (SNT).FindingsThe study extends the tenets of the SET and extends the applicability of SNT to a virtual workplace. The study suggests that managers should introduce semi-organized virtual fun during scheduled breaks within work hours to aid in virtual socialization, which further aids in the formation and strengthening of “professional ties” in the virtual workplace.Originality/valueThis study is the first of its kind to conceptualize a model for virtual fun in the virtual workplace.
Do changes in distributors' incentive structure drive mutual fund flows?
Authors: Sandhu Harsimran , Guha Deb Soumya 
Published: January 2023

PurposeThis study estimates the impact of changes in the mutual fund distributor incentive structure on distributor-advised mutual fund flows. The authors employ two recent major policy interventions by the Indian self-regulatory authority and the financial market regulator – one partial ban and another complete ban on upfront commissions – paid to mutual fund distributors on distributor-advised mutual fund flows.Design/methodology/approachThe authors use novel distributor-level data across the 198 largest distributors in India between 2013 and 2020 and a series of pooled panel random-effect generalized least squares models with robust standard errors to explore the effect of changes of distributor commissions on distributor assets-under-management (AUM), gross sales, commissions and changes (%) in the number of investors in alternate investment avenues like portfolio management services (PMS).FindingsChanges in the incentive structure have a significant negative effect on mutual fund flows at an aggregate level and within MF distributor categories. A significant diversion of investor funds toward PMS is noted, which paid higher upfront commissions to distributors during the same period.Practical implicationsThe authors posit that these two developments are not mutually independent and that both fall out of the aforementioned policy changes by Securities and Exchange Board of India and Association of Mutual Funds in India. The study findings have implications for all stakeholders in the Indian mutual fund industry and, by extension, for Indian and global alternative investment avenues.Originality/valueThis study is the first to explore the effects of these two major policy interventions by regulators on mutual fund flows in India.
Collaborative research services: a peer-led cohort approach
Authors: Johnson Matthew Weirick , Bowline Estéfani , King Diana Leigh , Osuna-Garcia Antonia , Page Sylvia , Tadesse Alohie , Tarmey Maggie , Vest Matthew 
Published: January 2023

PurposePrior to 2020, University of California, Los Angeles (UCLA) Library's research services spanned multiple service points. Multiple locations were staffed by Library Student Research Assistants (LSRAs) and each location was supervised independently. While efforts to increase collaboration had been underway, much of the work and services remained siloed and often duplicated training and service hours.Design/methodology/approachWith the onset of coronavirus disease 2019 (COVID-19), UCLA Library rapidly transitioned from entirely in-person to entirely online services. With multiple service points pivoting, UCLA was redundant to have multiple online desks providing Zoom appointments and that quickly became apparent. Moreover, transitioning in-person student work to remote work was paramount to providing both normal services to users and allowing LSRAs to keep jobs during a time of uncertainty and insecurity.FindingsWhile the authors' original consolidation of services and implementation of shared supervision was a result of the pandemic and primarily involved online services, the authors have maintained this shared approach and collaborative vision in returning to in-person services. For the past year, the authors have offered shared in-person (at two library locations) and online services. As subject-specific library locations begin to reopen their desks, the authors continue to identify ways to leverage shared supervision and a robust referral model for those on-site services while negotiating student staffing and the need for both general and subject-specific services.Originality/valueThe authors present a novel approach to peer-to-peer teaching and learning and research services and shared student worker supervision with services coordinated across multiple locations and disciplines within a large academic library serving a large student population.
Predicting primate–parasite associations using exponential random graph models
Authors: Herrera James P. , Moody James , Nunn Charles L. 
Published: January 2023

Abstract

Ecological associations between hosts and parasites are influenced by host exposure and susceptibility to parasites, and by parasite traits, such as transmission mode. Advances in network analysis allow us to answer questions about the causes and consequences of traits in ecological networks in ways that could not be addressed in the past.

We used a network‐based framework (exponential random graph models or ERGMs) to investigate the biogeographic, phylogenetic and ecological characteristics of hosts and parasites that affect the probability of interactions among nonhuman primates and their parasites. Parasites included arthropods, bacteria, fungi, protozoa, viruses and helminths.

We investigated existing hypotheses, along with new predictors and an expanded host–parasite database that included 213 primate nodes, 763 parasite nodes and 2319 edges among them. Analyses also investigated phylogenetic relatedness, sampling effort and spatial overlap among hosts.

In addition to supporting some previous findings, our ERGM approach demonstrated that more threatened hosts had fewer parasites, and notably, that this effect was independent of hosts also having a smaller geographic range. Despite having fewer parasites, threatened host species shared more parasites with other hosts, consistent with loss of specialist parasites and threat arising from generalist parasites that can be maintained in other, non‐threatened hosts. Viruses, protozoa and helminths had broader host ranges than bacteria, or fungi, and parasites that infect non‐primates had a higher probability of infecting more primate species.

The value of the ERGM approach for investigating the processes structing host–parasite networks provided a more complete view on the biogeographic, phylogenetic and ecological traits that influence parasite species richness and parasite sharing among hosts. The results supported some previous analyses and revealed new associations that warrant future research, thus revealing how hosts and parasites interact to form ecological networks.
Effect of sodium trimetaphosphate on the physicochemical properties of modified soy protein isolates and its lutein‐loaded emulsion
Authors: Lu Xingxing , Yin Qi , Zheng Zhi , Mu Dongdong , Zhong Xiyang , Luo Shuizhong , Zhao Yanyan 
Published: January 2023

AbstractDue to people's pursuit of healthy and green life, soy protein isolate (SPI) is occupying a larger and larger market share. However, the low solubility of SPI affects its development in the field of food and medicine. This paper aimed to investigate the effects of sodium trimetaphosphate (STMP) on the functional properties and structures of phosphorylated SPI and its lutein‐loaded emulsion. After modification by STMP, the phosphorus content of phosphorylated SPI reached 1.2–3.61 mg/g. Infrared spectrum and X‐ray photoelectron spectrum analysis confirmed that PO43− had phosphorylation with –OH in serine of SPI molecule. X‐ray diffraction analysis showed that phosphorylation destroyed the crystal structure of protein molecules. Zeta potential value of phosphorylated SPI decreased significantly. When STMP addition was 100 g/kg, particle size of protein solution decreased to 203 nm, and solubility increased to 73.5%. Furthermore, emulsifying activity and emulsifying stability increased by 0.51 times and 8 times, respectively. At the same protein concentration (1%–3% [w/w]), lutein‐loaded emulsion prepared by phosphorylated SPI had higher absolute potential and smaller particle size. The phosphorylated protein emulsion at 2% concentration had the best emulsion stability after storage for 17 days.Practical ApplicationPhosphorylation significantly improved the emulsifying properties and solubility of SPI. Phosphorylated SPI significantly improved the stability of lutein‐loaded emulsion. It provides theoretical basis for the application of phosphorylated SPI as emulsifier in delivery system and broadens the development of lutein in food and medicine field.
Adjuvant chemotherapy in node‐positive patients after esophagectomy for esophageal squamous cell carcinoma
Authors: Jeon Yeong Jeong , Cho Jong Ho , Choi Yong Soo , Shim Young Mog , Sun Jong‐Mu , Kim Hong Kwan 
Published: January 2023

AbstractBackgroundThe role of adjuvant chemotherapy in esophageal squamous cell carcinoma (ESCC) remains controversial. This study aimed to evaluate the impact of adjuvant chemotherapy on survival in patients with positive nodes after surgery for ESCC.MethodsWe retrospectively reviewed the survival outcomes of node‐positive patients with ESCC who underwent curative resection with or without adjuvant chemotherapy between January 1994 and December 2015.ResultsWe analyzed 460 patients (333 adjuvant chemotherapy, 127 surgery alone). The surgery‐alone group was older (64 vs. 60 years, p < 0.001) and had more comorbidities (p = 0.004) than the adjuvant chemotherapy group. After propensity score matching, overall survival (OS) and recurrence‐free survival (RFS) of the adjuvant chemotherapy group were better than those of the surgery‐alone group: 5‐year OS rate 62.7% (95% confidence interval [CI] 54.4–72.3%) vs. 46.8% (95% CI 38.5–57%, p = 0.001) and 5‐year RFS rate 53.9% (95% CI 45.4–63.9%) vs. 36.2% (95% CI 28.3–46.3%, p < 0.001). Notably, in patients with pT3–4 stage, the adjuvant chemotherapy group had significantly better 5‐year OS rate (41.3% [95% CI 29.3–58.3%] vs. 18% [95% CI 10–32.5%], p = 0.01) and 5‐year RFS rate (37% [95% CI 25.3–53.9%] vs. 12% [95% CI 5.7–25.4%], p < 0.001) than in the surgery‐alone group. In multivariable analysis, adjuvant chemotherapy had a favorable effect on both OS (hazard ratio [HR] 0.562, 95% CI 0.426–0.741, p < 0.001) and RFS (HR 0.702, 95% CI 0.514–0.959; p = 0.026).ConclusionAdjuvant chemotherapy may improve survival in node‐positive patients with ESCC, especially in those with pT3–4 stage.