bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal response of a prototype building with composite construction using LGS-Ferrocement sandwich wall panels.
Authors: Patil Nikhil , Kulkarni Mrudula , Lele Mandar , Shinde Sumant 
Published: May 2023

Abstract
In India, the modular precast construction sector, light gauge steel or commonly known as cold-formed steel and precast Ferrocement composite structures are gaining attention. This composite construction is a sustainable way of construction, leaving a low carbon footprint, as compared to conventional RCC construction. It enables fast construction with lower overheads, such as material transportation, labor cost, and amazing speed of construction thus making it an overall cost effective technology. The technology for typical G+5 residential building made of precast ferrocement panels combined with light gauge steel composite structure have been established. It claims to offer the practically enhanced solution to substitute the conventional RCC structure. Once structural performance is established, it is important to establish the thermal performance of this innovative construction technology for residential use purpose. This article represents the laboratory prototype study of residential space subjected to temperature variation, which may affect the comfort of the dwellers, energy requirement for maintaining working temperature for the building. Analytical and experimental approach establishes the thermal response of this precast composite construction technology and supports its futuristic development.
Bayesian optimization of wall-normal blowing and suction-based flow control of a NACA 4412 wing profile
Authors: Mallor Fermin , Semprini-Cesari Giacomo , Mukha Timofey , Rezaeiravesh Saleh , Schlatter Philipp 
Published: May 2023

Abstract
Active flow-control techniques have shown promise for achieving high levels of drag reduction. However, these techniques are often complex and involve multiple tunable parameters, making it challenging to optimize their efficiency. Here, we present a Bayesian optimization (BO) approach based on Gaussian process regression (GPR) to optimize a wall-normal blowing and suction control scheme for a NACA 4412 wing profile at two angles of attack: 5 and 11 degrees, corresponding to cruise and high-lift scenarios, respectively. An automated framework is developed by linking the BO code to the CFD solver OpenFOAM. RANS simulations (validated against high-fidelity LES and experimental data) are used in order to evaluate the different flow cases. BO is shown to provide rapid convergence towards a global maximum, even when the complexity of the response function is increased by introducing a model for the cost of the flow control actuation. The importance of considering the actuation cost is highlighted: while some cases yield a net drag reduction (NDR), they may result in an overall power increase. Furthermore, optimizing for NDR or net power reduction (NPR) can lead to significantly different actuation strategies. Finally, by considering losses and efficiencies representative of real-world applications, still a significant NPR is achieved in the 11° case, while net power reduction is only marginally positive in the 5° case.
A General Solution for Rotating Lattices of Identical Point Vortices
Authors: Robertson Phillip 
Published: May 2023

Abstract

The rotating equilibrium solutions of N identical point vortices are the minimal energy projections of a higher dimensional object to the xy plane, in this case, an N - 1 dimensional regular simplex. Parameterizing the point vortex Hamiltonian with this fundamental geometrical object leads to a simple bivector condition which determines the equilibrium states and resolves the origin of the asymmetric solutions. This novel approach uses the geometric product and the multivector derivative, ∂X, of the Hamiltonian in the geometric algebra, Cl(N - 1, 0) to find a geometric condition which determines the equilibrium states. The resulting bivector equation is then used as the input to an optimizer which rotates a simplex until the equilibrium condition is met, leading to a wealth of new solutions. If the vertices of the oriented simplex are projected to the x-axis, the values form the roots of the Hermite polynomials, HN(x), and obey the Stieltjes relations, capturing the collinear solutions. The vortex simplex exhibits a striking geometrical connection with the amplituhedron of quantum field theory and gives deep insight into the quantization of a classical system.
Climatic shocks and food security among agricultural households in Togo
Authors: GNEDEKA Kodjo Théodore , WONYRA Kwami Ossadzifo 
Published: May 2023

Abstract
The general objective of this paper is to analyse the effect of climate shocks on the food security of agricultural households in Togo. The generalized ordered logit model and the fixed-effects ordered logistic regression were applied to data from the EHCVM, (2018) and QUIBB, 2011 and 2015 conducted by INSEED in Togo. The Food Insecurity Experience Scale and the food consumption score are used as food security indicators. The study results reveal that climate shocks positively affect moderate and severe food insecurity among agricultural households. However, farm households that have experienced climate shocks but report being wealthy, possessing social capital, or having access to agricultural credit have a low probability of being food insecure in Togo. The study suggests policies to strengthen the resilience of farm households to climate shocks to improve their food security.
JEL code: O12, Q54, Q18
EFFECT OF VIRTUAL REALITY TRAINING ON BALANCE AND FUNCTIONALITY IN CHILDREN WITH CEREBRAL PALSY: A RANDOMIZED CONTROLLED TRIAL
Authors: FİDAN Öznur , GENÇ Arzu 
Published: May 2023

Purpose: The aim of this study was to investigate the effectiveness of virtual reality training on balance and functionality in children with Cerebral Palsy.
Methods: Children with spastic Cerebral Palsy were randomly divided into the virtual reality training group (27 children, mean age: 9.2 years) and control group (25 children, mean age: 9.4 years). The virtual reality training group received virtual reality training using the XBox One Kinect gaming system and the control group received conventional physiotherapy training for eight weeks. The Pediatric Balance Scale, The Gross Motor Function Measurement-88, The Quality of Upper Extremity Skills Test, The Functional Reach Test, The Sit to Stand Test and The Pediatric Disability Evaluation Inventory were measured at baseline and after treatment sessions.
Results: Total motor function, upper extremity skills and balance in both groups improved after training (p < 0.05). A comparison between groups demonstrated that the improvements in upper extremity functions was greater in the control group than in the virtual reality training group (p < 0.05).
Conclusion: The results of our study showed that Kinect-based virtual reality training is beneficial in improving balance, motor function and upper extremity skills in children with Cerebral Palsy.
A COMPARISON OF MANUAL THERAPY AND EXTRACORPOREAL SHOCKWAVE THERAPY IN PATIENTS WITH CARPAL TUNNEL SYNDROME
Authors: TORUN Neslihan , TUNCER Ayşenur 
Published: May 2023

Purpose: To investigate the effects on pain, symptom severity, and functionality of different physiotherapy methods applied to patients with carpal tunnel syndrome and to evaluate the advantages of these over each other.
Methods: A total of 75 patients (69 females, 6 males) aged 25-60 years were separated into 3 groups. The patients in Group 1 were given a home exercise program (HP), including median nerve and tendon gliding exercises. Group 2 received the same HP plus manual therapy (MT), including soft tissue and joint mobilisation. Group 3 received the same HP plus extracorporeal shockwave therapy (ESWT). Pain severity was evaluated with a Visual Analog Scale. Symptom severity and levels of functionality were evaluated with the Boston Carpal Tunnel Syndrome Questionnaire and the Cochin Hand Function Questionnaire. All the patients were evaluated before and after treatment.
Results: While there was a significant decrease in the resting and activity pain levels of each 3 groups after the treatment (p 0.05). However, the pain values of these two groups were significantly decreased compared to the EP group (p
NÖROMUSKÜLER HASTALIKLARDA GÖRÜLEN POSTÜR BOZUKLUĞU İLE HASTALIK ŞİDDETİ, FONKSİYONEL KAPASİTE, GÜNLÜK YAŞAM AKTİVİTELERİ VE DENGE ARASINDAKİ İLİŞKİNİN ARAŞTIRILMASI
Authors: DEMİRHAN İzel , KILINÇ Muhammed 
Published: May 2023

Amaç: Bu çalışmanın amacı, nöromusküler hastalığa sahip erişkin bireylerde postür bozukluklarını araştırmak ve postür bozukluklarının hastalık şiddeti, fonksiyonel kapasite, günlük yaşam aktiviteleri, denge ve düşme ile ilişkisini belirlemektir.
Yöntem: Çalışmaya nöromusküler hastalık tanısı konan ve yaş ortalaması 36,34 ± 14,03 yıl olan 47 hasta dahil edilmiştir. New York Postür Derecelendirme Ölçeği (NYPD) ile genel vücut postürü, fleksible ruler ile torakal kifoz açısı (TKA)- lumbal lordoz açısı (LLA) değerlendirilmiştir. Skolyometre kullanılarak olası skolyoz varlığı ve pelvik asimetri değerlendirilmiştir. Üst Ekstremite (ÜEFS) ve Alt Ekstremite Fonksiyon İndeksi (AEFS) ile hastalık şiddeti, 2 Dakika Yürüme Testi (2DKYT) ile fonksiyonel kapasite, Zamanlı Kalk Yürü Testi (ZKYT) ile denge ve düşme riski, Fonksiyonel Bağımsızlık Ölçeği (FIM) ile günlük yaşam aktiviteleri kaydedilmiştir.
Sonuçlar: Postüral deformitelerin değerlendirilmesi sonucunda hastaların NYPD’si ortalamasının 40,24±9,56 olduğu belirlenmiştir. Yapılan ölçümlerde hastaların %46,34’ünde TKA’nın, %24,39’unda ise LLA’nın açısının norm değerlerin dışına çıktığı ve skolyometre ölçümleri sonucunda 30 hastada (%73,2) olası skolyoz varlığı, 11 hastada (%26,8) spinal asimetri olduğu, 27 hastada (%65,9) ise pelvik asimetri olduğu bulunmuştur. NYPD ile ÜEFS, 2DKYT, FIM ve ZKYT arasında istatiksel olarak anlamlı ilişki olduğu belirlenmiştir (p
Assessing the leapfrogging potential to water sensitive: the Dutch case of Zwolle
Authors: Casiano Flores Cesar , Rodriguez Müller A. Paula , Dolman Nanco , Özerol Gül 
Published: May 2023

AbstractUrban floods can cause significant damage and are expected to become more common due to climate change. Previous research has identified that climate change adaptation in cities requires the development of blue-green infrastructure (BGI), and it is expected that cities can leapfrog to a water-sensitive state by implementing BGI. However, leapfrogging is context-dependent, and little is known about how governance factors affect leapfrogging, particularly in midsize cities. This paper addresses this knowledge gap, providing empirical insights into leapfrogging by assessing the governance factors that support or restrict BGI implementation in Zwolle (The Netherlands) towards reaching a water-sensitive state. For the analysis, we employ a governance assessment tool and three catalytic factors that promote leapfrogging. The results show that the governance context supports leapfrogging at a moderate to high level. This means that while the governmental levels and stakeholder networks collaborate to support climate change adaptation of the city, new legislation on BGI and citizens’ involvement in climate change adaptation projects could increase the leapfrog possibilities for Zwolle in achieving its goal of becoming climate-proof by 2050.
Assessing the effectiveness of filtration + UV-C radiation for the treatment of simulated ballast water at various holding times
Authors: Wang Yanan , Wang Qiong , Dong Kairui , Chen Jianwu , Wu Huixian 
Published: May 2023

Abstract

In recent years, the issue of invasive alien species brought on by ballast water has drawn increasing attention, and advances in ballast water treatment technologies have been made. One of the most popular combined ballast water treatment technologies utilized in ballast water management systems (BWMSs) globally is filtration + UV-C radiation. During the actual voyage of the ship, ballast water is treated by the BWMS and then enters the dark ballast tanks until the ballast water is discharged. Marine organisms are able to complete DNA damage caused by UV radiation in dark ballast tanks. Therefore, the length of holding time affects the effectiveness of the BWMS in treating ballast water. The objective of this study was to examine the efficacy of filtration + UV-C irradiation treatment at different holding times for the removal or inactivation of phytoplankton and zooplankton populations during simulated ballast water treatment. Results indicate that the holding time after the filtration + UV-C radiation treatment increased the inactivating efficacy, especially for zooplankton in natural seawater. For phytoplanktons in ballast water, the strongest impact on the treatment efficacy was reached with a holding time of 24 h.
Understanding Protein Functions in the Biological Context
Authors: Wang Tianwen , Zhang Wei 
Published: May 2023

Abstract:
Proteins are essential biomacromolecules in all living systems because they are the
prominent ultimate executives of the genetic information stored in DNA. Thus, studying protein is one
of the central tasks in biological sciences. The complexity, diversity, and dynamics of a protein's
structure, function, and structure-function relationship, the inherent structural fragility and thus the
requirements on handling proteins to maintain protein's structural and functional orderliness make it a
rather tricky task to work with protein. The approach to understanding the functions of a protein has
been progressing steadily. In this paper, we reviewed the progress on the approach to the functional
study of proteins that tremendously contributed to understanding their biological significance.
Emphasis was put on the advances in the age in which high-throughput DNA sequencing and
bioinformatics analysis are revolutionizing biological study.
Natural Compounds Used for Treating Hair Loss
Authors: Gasmi Amin , Mujawdiya Pavan Kumar , Beley Natalia , Shanaida Mariia , Lysiuk Roman , Lenchyk Larysa , Noor Sadaf , Muhammad Akram , Strus Oksana , Piscopo Salva , Komisarenko Andriy , Fedorovska Maryana , Bjørklund Geir 
Published: May 2023

Abstract:
Hair loss or alopecia is a common dermatological condition affecting up to 2% of the world population.
It is often caused by hereditary factors, such as male or female pattern baldness, but it can also result from
various environmental factors, an unbalanced diet, or chronic illness. While hair loss is not life-threatening, it
can cause significant anxiety, depression, and other psychological problems, ultimately impacting an individual's
quality of life. Various treatments for hair loss, including both synthetic drugs, such as minoxidil and finasteride,
or medicinal herbs, have been approved by the Food and Drug Administration. Despite synthetic drugs'
effectiveness, they may come with potential side effects. Natural remedies have been proposed as a viable option
for treating hair loss because many chronic disorders can cause alopecia. As such, this review focuses on
identifying alternative, efficient treatment agents with limited side effects. Specifically, it looks into medicinal
plants as potential healing agents for treating hair loss. To gather relevant information for the study, multiple
databases were searched, including Scopus, PubMed, and Google Scholar. A comprehensive search was conducted
using a range of search terms, such as “hair loss”, “alopecia”, “natural remedies for hair loss”, “herbal
treatments for hair loss”, and others to extract relevant scientific articles. Many medicinal plants and natural
compounds have shown potential in reducing hair loss, thanks to their anti-inflammatory and antioxidant properties
and the ability to improve local metabolism when applied externally. According to existing literature, herbal
extracts and formulations derived from plants, such as Urtica dioica, Humulus lupulus, Serenoa repens, Vitis
vinifera, Pygeum africanum, Cucurbita pepo, etc., as well as certain individual herbal compounds, micronutrients,
bee products, and keratin, may be effective in reducing hair loss directly or indirectly. Research
suggests that medicinal plants and a variety of natural compounds hold promise in promoting hair growth and
preventing alopecia.
Quantitative Proteomics Combined with Network Pharmacology Analysis
Unveils the Biological Basis of Schisandrin B in Treating Diabetic
Nephropathy
Authors: Song Jianying , Zhang Bo , Zhang Huiping , Cheng Wenbo , Liu Peiyuan , Kang Jun 
Published: May 2023

Background:
Diabetic nephropathy (DN) is a major complication of diabetes. Schisandrin
B (Sch) is a natural pharmaceutical monomer that was shown to prevent kidney damage
caused by diabetes and restore its function. However, there is still a lack of comprehensive and systematic
understanding of the mechanism of Sch treatment in DN.

Objective:
We aim to provide a systematic overview of the mechanisms of Sch in multiple
pathways to treat DN in rats.

Methods:
Streptozocin was used to build a DN rat model, which was further treated with Sch. The
possible mechanism of Sch protective effects against DN was predicted using network pharmacology
and was verified by quantitative proteomics analysis.

Results:
High dose Sch treatment significantly downregulated fasting blood glucose, creatinine,
blood urea nitrogen, and urinary protein levels and reduced collagen deposition in the glomeruli
and tubule-interstitium of DN rats. The activities of superoxide dismutase (SOD) and plasma glutathione
peroxidase (GSH-Px) in the kidney of DN rats significantly increased with Sch treatment. In
addition, the levels of IL-6, IL-1β, and TNF-α were significantly reduced in DN rats treated with
Sch. 11 proteins that target both Sch and DN were enriched in pathways such as MAPK signaling,
PI3K-Akt signaling, renal cell carcinoma, gap junction, endocrine resistance, and TNF signaling.
Furthermore, quantitative proteomics showed that Xaf1 was downregulated in the model vs. control
group and upregulated in the Sch-treated vs. model group. Five proteins, Crb3, Tspan4, Wdr45,
Zfp512, and Tmigd1, were found to be upregulated in the model vs. control group and downregulated
in the Sch vs. model group. Three intersected proteins between the network pharmacology
prediction and proteomics results, Crb3, Xaf1, and Tspan4, were identified.

Conclusion:
Sch functions by relieving oxidative stress and the inflammatory response by regulating
Crb3, Xaf1, and Tspan4 protein expression levels to treat DN disease.
Multitargeting: An Alternative Approach to Tackle Multidrug Resistance
in Tuberculosis
Authors: Hazra Satakshi , Hazarika Risha , Patra Sanjukta 
Published: May 2023

Background:
The prevalence of drug-resistant organisms has steadily increased over the past few decades worldwide. Especially in tuberculosis (TB) disease, the problems of co-morbidity and the rapid emergence of multidrug resistance have necessitated the development of multitarget-based therapeutic regimens. Several multitargeting compounds against Mycobacterium tuberculosis (Mtb) have been studied through novel in silico tools but these have rendered reduced efficacy in clinical trials. The authors have focussed on many exotic targets belonging to crucial Mtb survival pathways whose molecular structures and functions are underexplored. Likewise, insights into the hidden possibilities of promiscuous compounds from natural products or repurposed drugs to inhibit other cellular proteins apart from their validated targets are also depicted in this review. In addition to the existing line of drugs currently recommended for multidrug-resistant TB, newer host-directed therapies could also be fruitful. Furthermore, several challenges, including safety/efficacy ratios of multitarget compounds highlighted here, can also be circumnavigated by researchers to design “smart drugs” for improved tuberculosis therapeutics.

Conclusion:
A holistic approach towards alleviating the existing drawbacks of drug discovery in drug-resistant TB has been outlined. Finally, considering the current needs, the authors have put forward an overall summary of possible trends in multitargeting that are significant for futuristic therapeutic solutions.
Improving Oral Bioavailability of Herbal Drugs: A Focused Review of
Self-Emulsifying Drug Delivery System for Colon Cancer
Authors: Bhardwaj Khushboo , Sharma Arun , Kumar Rajan , Tyagi Varnit , Kumar Rajesh 
Published: May 2023

Abstract:
One of the most frequent malignancies in the world is colon cancer. Both men and women
are affected in the same way. The colon, which makes up the last part of the digestive system and is
where water and minerals from food waste are absorbed, is vulnerable to cancer. The most suitable
technique of drug administration is oral administration. Aqueous solubility is low in more than 40% of
novel chemical entities, resulting in poor oral drug administration. In the formulation of oral medications,
low inconsistent bioavailability is a major challenge. Increasing medication bioavailability is one
of the most difficult aspects of pharmacological development. Self-nano-emulsifying drug delivery systems
(SNEDDS) have been a potential platform for biopharmaceutical classification system class II and
IV drugs for oral delivery. Enhanced bioavailability and solubility, control of toxicity, pharmacological
effects, improved stability, improved tissue macrophage dispersion, prolonged delivery, and resistance
to physical and chemical degradation are just a few benefits of SNEDDS for herbal drugs. To increase
activity and address problems associated with herbal drugs, nanosized modern drug delivery technologies
are expected to have a promising future. Improved patient compliance, fewer problems with liquid
SNEDDS filled in capsules, and enhanced stability SNEDDS are all benefits of converting liquid
SNEDDS to solid oral dosage forms or solid SNEDDS. SNEDDS differs from previous solubility augmentation
methods due to its biodegradable components, simplicity of large-scale production, and range
of drug-targeting possibilities.
The Applications of CRISPR/Cas9 System for Urinary System Tumor
Authors: Li Shulin , Wu Yuqi , Wang Xiangwei 
Published: May 2023

Abstract:
Tumors of the urinary system include those in the urinary and reproductive systems, of which tumors of the prostate, bladder, and kidney have the highest incidence. In recent years, due to changes in dietary structure, prostate cancer has become the most common type of male genitouri-nary system cancer. Furthermore, due to tobacco consumption, increases in industrialization, and the age of the population, the incidence of bladder cancer in both males and females in both urban and rural areas, has shown an increasing trend. The incidence and mortality of kidney cancer have also increased and negatively affected the lives and health of all residents. While surgery, radiother-apy, and chemotherapy have greatly improved the cure and survival rates of patients with urinary tumors, we lack methods for early detection and effective long-term treatment. New tools and methods for diagnosis and treatment are thus urgently needed. Recently, CRISPR/Cas9 has become an efficient method to alter the genome in many organisms. It can be used to activate or inhibit gene expression, which greatly facilitates the editing of targeted genes, both in vivo and in vitro. It pro-vides a powerful scientific research tool to analyze the mechanisms of disease occurrence and de-velopment and to develop advanced targeted drug delivery. The diagnosis and treatment of human tumors will consequently be improved as this technology will surely accelerate cancer research. In this article, we discuss how CRISPR/Cas9 technology can be used to research and treat genitouri-nary system tumors will consequently be improved as this technology will surely accelerate cancer research. Here, we review the current applications of CRISPR/Cas9 technology for genitourinary system tumor research and therapy.