bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Pericapsular Nerve Group (PENG) Block in Hip Surgery
Authors: Dusak I Wayan Suryanto , Ciatawi Kartini 
Published: February 2023

Introduction: Pericapsular nerve group (PENG) block is a recently introduced pain control method indicated for hip fracture. Anterior capsule is the most abundantly innervated site of the joint. Therefore, unlike the common performed peripheral block, PENG block was proposed to provide a complete analgesia. Objective: This systematic review aims to evaluate the effect of PENG block in hip fracture surgery and hip arthroplasty. Methods: A comprehensive search was conducted in PubMed, ScienceDirect, and ClinicalKey databases until July 31st 2022 with the following keyword: “pericapsular nerve group block”. Results: Nine studies were included in the final qualitative synthesis. Compared to most commonly performed peripheral nerve blocks (femoral nerve block (FNB) or fascia iliac compartment block (FICB)), the PENG block seemed to offer better pain control (three studies reported better post-operative pain score (VAS) and one showed immediate pain improvement at 10, 20, and 30 minutes after block). The PENG block also increased the period of analgesic-free window and lowered the amount of opioid use. Mobility and length of stay were reported superior in PENG block. A study comparing PENG block with periarticular infiltration also reported lower cumulative opioid consumption, although it is not significant. In one study, PENG block was compared with no block and resulted in significantly better post-operative pain, lesser opioid dose, longer time to first opioid need, and better mobility. If not fewer, adverse events were comparable in PENG block than other techniques. Conclusion: Pericapsular nerve group block appears to have beneficial effects in hip surgery. This analgesic method may provide better outcomes in pain control, use of opioid, mobility, and length of hospital stay. However, future studies are expected to confirm these results.
Peroneal Tendon Dislocation Treated with Arthroscopic Approach: A Case Report
Authors: Frinces Hefson D , Winata Fahroni C 
Published: February 2023

Peroneal tendon dislocation is usually manifested as ankle instability and pain. Peroneal tendon dislocation is caused by ruptured of superior peroneal retinaculum (SPR) due to anatomical abnormality. SPR can be damaged due to excessive contraction force of dorsiflexion of the foot. The epidemiology of this pathology is also uncertain, because peroneal tendon dislocation is often mistaken for lateral ankle ligament sprain. The treatment should include conservative treatment and surgical treatment if it fails. A 20-year-old Indonesian Male attended orthopedic consultation with pain and snapping of the lateral side of left foot from 2 years ago after twisting his ankle during a recreational sport. Snapping was felt when doing sport exercise and in certain position. The tendon dislocation can be seen after that. On examination, he felt pain on palpation and snapping on lateral side of the ankle. The left ankle was snapped in a dorsiflexion and plantarflexion positions and can return into normal position. After conservative therapy, the condition did not improve. Then surgical intervention was suggested. Patient was operated on June 21st 2022 on a operating room with lateral decubitus position under subarachnoid anesthesia. The surgery was done with arthroscopic approach. During operation we found a SPR disruption, peroneus longus tendon longitudinal tear, low lying peroneus brevis muscle belly and shallow retromaleolar groove. These finding may increase the risk of dislocation. We performed a peroneus longus debridement, peroneal brevis muscle excision, retromaleolar groove deepening, and SPR repair are our best choice of treatment. Short leg splint and physiotherapy exercise were applied after surgery. Presented case of peroneal dislocation is very low. Usually for this case is best treated with surgical intervention. By using arthroscopy, we can detect abnormality and treat them at once. SPR repair and groove deepening with arthroscopic approach can offers a satisfactory outcome.
Comparation of Clinical Outcome of Surgical vs. Conservative Management for Ankle Fracture Weber Type B: A Systematic Review and Meta-analysis
Authors: Mahardika I Made Yudi , Astawa Putu 
Published: February 2023

Introduction: An ankle fracture or broken ankle occurs when the distal tibia or fibula, which make up the ankle joint, are fractured or broken. Soft-tissue injuries, especially to the ankle ligaments, are frequently seen. Accurate reduction of the fracture and syndesmosis is crucial in the treatment of ankle fractures in order to promote bone union and enhance patient functional results. While more unstable injuries are typically treated surgically with open reduction and internal fixation (ORIF) utilizing g a variety of techniques, including plates and screws or tightrope, more stable injuries are frequently treated conservatively with close contact casts or braces. There isn’t a recent systematic review in the literature that covers the best choice of treatment for Weber B fractures. Thus, it was essential to perform this study in order to assess the base of evidence about the surgical and non-surgical treatment of Weber B fractures. Method: A systematic review was comparison of clinical outcome between surgical versus conservative for Ankle Fracture Weber type B. in 256 records from various databases. After the process of identification, screening, eligibility, duplication elimination, and exclusion, the remaining 4 studies were included in qualitative and quantitative synthesis. The Review Manager version 5.4 software (RevMan; The Cochrane collaboration Oxford, England) to perform all statistical analyses Discussion: This study reviewed 4 trials with a total of 1208 participants. Of these, 4 trials focused on AO-type-B distal fibula fracture. Overall, all of the studies that reported functional outcomes found no difference between surgical and conservative management. Conclusion: Both surgical and conservative care of displaced or unstable ankle fractures in adults result in similar functional outcomes and are both appropriate treatment methods
Controversial Treatment Choice to Manage Lateral Meniscus Posterior Root Tear: A Case Report
Authors: E Handi Suntama , Nugraha Muhammad Ilham Satya , Putra Ramadhan Ananditia 
Published: February 2023

Introduction: Meniscus root tears are defined as radial tears within 1 cm of the meniscus insertion, or avulsions at the insertion of the meniscus. Based on tear morphology, there are 2 classification system for both medial and lateral posterior root tears. Lateral meniscus posterior root tear (LMPRT) is usually traumatic in nature and has been reported to occur in 7-10% of patients with anterior cruciate ligament (ACL) injury. The most commonly utilized treatments for LMPRT include non-operative treatment, partial meniscectomy, or repair. However, studies evaluating the clinical success of partial meniscectomy for LMPRT are contradictory. Case Report: A 18 years old man came to the orthopaedic clinic with complaints of pain in the right knee, after 2 months excessive physical training to join the police academy. Physical examination of the right knee showed positive results on McMurray and Thesaly’s test. According the combination of the cleft, truncated triangle, and ghost signs on the patient’s MRI examination which showed there was a lateral meniscus posterior root tear of the right knee without ACL injury. Meniscus repair was performed for this patient at the beginning, but apparently the meniscus can not be repositioned. Therefore, we decided that Arthroscopy Partial Meniscectomy (APM) was the best option for this patient. Conclusion: Even though APM long term outcomes is still controversial, when repair is not possible, APM is preferred to get short term benefits after the surgery, such as shorter recovery time and less revision surgery rates.
Intra-articular injection of human umbilical cord-derived mesenchymal stem cells in sheep models of meniscectomy-induced osteoarthritis: An experimental study
Authors: Lubis Andri Maruli Tua , Situmeang Adrian , Canintika Anissa Feby , Subangkit Mawar , Rakhmawati Handina , Nugroho Stefan , Prawira Matheus Alvin , Murti Harry , Boediono Arief 
Published: February 2023

Introduction: Autologous mesenchymal stem cells (MSC) implantation suspended in hyaluronic acid (HA) has been proven to delay worsening of articular cartilage degeneration in the knee joint. This has been the treatment of choice for young patients with knee osteoarthritis (KOA); however, it is associated with morbidities such as requirement of multiple procedures, donor site morbidity and failure in achieving cultured cells with chondrogenic properties. Our study investigates the possibility of direct intra articular injection of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for sheep models of meniscectomy-induced osteoarthritis. Methods: Twelve sheeps with the same characteristics was osteoarthritically induced with lateral meniscectomy and a series of routine exercise. Those sheep were divided into four groups with 3 sheep each. The groups are the control group, intra articular HA (hyalgan G-F 20; Synvisc®) injection group, intra articular hUC-MSCs group, intra articular hUC-MSCs suspended in HA group. The sheeps were sacrificed four weeks post-treatment for gross pathology and histopathology graded according to the Osteoarthritic Research Society International (OARSI) system. Results: The intra articular hUC-MSCs suspended in HA group showed better gross pathology and histopathology grade compared to control groups (p<0.05) according to the OARSI system. The hUC-MSCs suspended in HA group microscopically showed superior chondrocyte number and varying degrees of cellular regeneration of articular cartilage. Conclusion: The use of intra articular hUC-MSCs suspended in HA is an option in treating KOA. Its efficacy in articular cartilage regeneration would be further explained in clinical trials.
The Application of the Novel Femoral-Epiphyseal Acetabular Roof (FEAR) Index
Authors: Dusak I Wayan Suryanto , Ciatawi Kartini 
Published: February 2023

Introduction: Femoral-epiphyseal acetabular roof (FEAR) index is a recently introduced tool. It was proposed to be able to identify instability of the hip. Moreover, its use has been studied for predicting the outcome of surgery. Objective: We conducted a systematic review to evaluate the implication of FEAR index. Methods: A systematic computerised database search (Pubmed, ScienceDirect, and ClinicalKey) was performed until July 31st 2022 for articles related to FEAR index. Results: Eleven studies were included in this systematic review. The FEAR index showed a very good interobserver intraclass correlation coefficients (ICC) (range: 0.778-0.99). Five studies (553 hips) assessed the use of FEAR index for hip instability. All studies indicated that the FEAR index was associated with hip instability despite differences in diagnosis (three borderline dysplastic hip, one femoroacetabular impingement (FAI), one developmental dysplasia of hip (DDH)). Five other studies involving a total of 686 hips evaluated the relation of FEAR index and surgery outcome in borderline instability. Three studies demonstrated a significant relationship of FEAR index and surgery success, with two studies suggested combination of FEAR index with AWI and/or PWI and one study proposed the use of ≥4˚ as the cut-off value for predictor of failed surgery. Two remaining studies that dichotomised PENG block by the value of 2˚ failed to show a significant relationship between FEAR index and success of surgery. In addition, two studies reported that FEAR index was able to differentiate FAI from DDH and two others discovered that FEAR index was significantly different in types of received surgery. Conclusion: The FEAR index is a relatively new index and only few studies have been conducted. This index may become a useful tool; however, further studies with high-quality design are needed to confirm its utilities and determine cut-off values accordingly.
Development and Psychometric Properties of a health-promoting self-care behavior scale (HPSCB-S) in recovered patients from Drug Addiction
Authors: Narenji Mehrdad Assadian , Khazaee-Pool Maryam , Iranpour Abedin 
Published: February 2023

Abstract
Background and objectives
Drug addiction is a chronic and relapsing brain disease. Practicing self-care is one of the rules offered by therapists to improve the withdrawal process and prevent relapse. Based on the evidence, health beliefs, including Pender’s proposed model, are significantly effective in adopting self-care behaviors in patients. On the other hand, in order to evaluate preventive interventions regarding drug use and relapse of drug use; Having a good and appropriate tool is a special priority. Therefore, the present study aims to design and determine the psychometric characteristics of the questionnaire for measuring health-promoting self-care behaviors in patients recovered from drug addiction has been carried out in the west of Mazandaran province.

Methods
The current study is a cross-sectional descriptive methodological research. In the first stage, the items and primary classes of the new tool were extracted based on the review of studies consistent with Pender’s self-care promotion and a questionnaire was designed. In the second stage, the psychometric characteristics of the designed questionnaire were examined using face validity, content validity, construct validity and reliability. In the construct validity, the number of participants was 245 for exploratory factor analysis and 203 for confirmatory factor analysis. In the reliability test, 25 people participated to check internal consistency and test-retest. Random sampling was done from 12 drug addiction treatment clinics in two cities of Tonkabon and Ramsar in the west of Mazandaran province during 2021–2022. Data were analyzed using SPSS and AMOS software version 23.

Results
The exploratory factor analysis revealed 7 factors containing 29 item explained more than 61% of the total observed variance. The results of confirmatory factor analysis showed that the data fit the model. In the reliability test, Cronbach’s alpha coefficient indicated the appropriate internal consistency of the tool and retesting the tool with an interval of 2 weeks showed acceptable stability of the tool.

Conclusion
The present study showed that the researcher-made questionnaire has good validity and reliability and can be used to measure self-care behaviors of patients who have recovered from addiction in order to provide appropriate solutions to prevent the relapse of drug use.
RNA-seq reveals novel mechanistic targets of Livin in bladder cancer
Authors: Li Xianwen , Fu Chunhua , Li Guofeng , He Haolin 
Published: February 2023

Abstract
Background
Bladder cancer is a very common malignancy with a high recurrence rate. The survival of patients with muscle-invasive bladder cancer is poor, and new therapies are needed. Livin has been reported to be upregulated in bladder cancer and influence the proliferation of cancer cells.

Materials and methods
The Livin gene in human bladder cancer cell line T24 was knocked out, and the differentially expressed genes were identified by RNA-seq and qPCR.

Results
Livin knockdown affects gene expression and has strong negative effects on some cancer-promoting pathways. Furthermore, combined with bladder cancer clinical sample data downloaded from TCGA and GEO, 2 co-up-regulated genes and 58 co-down-regulated genes were identified and validated, which were associated with cancer proliferation and invasion.

Conclusion
All these results suggest that Livin plays an important role in bladder cancer and could be a potential anticancer target in clinical therapy.
Introducing assisted reproductive technologies in The Gambia, a survey on the perspectives of Gambian healthcare professionals and medical students
Authors: Bittaye Haddy , Mooney Jason P. , Afferri Anna , Balen Julie , Kay Vanessa 
Published: February 2023

Abstract
Background
Infertility remains a global reproductive health burden with the highest prevalence in low and middle-income countries. In sub-Saharan Africa, the ability to procreate holds great societal importance. Couples, and particularly women, with infertility can face devastating challenges, leading to social stigma, isolation and/or divorce. However, attention to addressing infertility is lacking in sub-Saharan Africa. In The Gambia, where this study is based, little is known about the potential for introduction of assisted reproductive technologies (ART) in the public health sector.

Methods
A quantitative survey was conducted using detailed questionnaires on infertility services available, staff knowledge, perceived barriers, and personal motivation to support assisted reproductive technologies. Data was collected electronically between April and June 2021 from healthcare providers (n = 70) in eleven health facilities throughout the country, as well as from medical students (n = 55) enrolled at The University of The Gambia.

Results
Basic infertility services were found to be lacking in the rural areas. Furthermore, 39% of staff (n = 27) providing fertility care had not receive any formal training on the topic. However, 91% of staff (n = 64) showed interest in acquiring additional knowledge and had a positive attitude towards supporting the introduction of ART. Perceived challenges of doing so included: (i) the competing importance of other health priorities; and (ii) religious and cultural barriers.

Conclusion
This survey highlights that expansion of infertility services is needed, especially in rural areas. Staff perceived the introduction of ART as important, but this should be coupled with specialized training, as most medical staff had not received any formal infertility training. Future care providers (current medical students) showed both interest in ART and reported having received some basic training in infertility management. Given the reported lack of infrastructure and services, additional targeted investment in infertility care, including ART, will be needed to improve reproductive health for all, countrywide.
The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review
Authors: Li Jie , Albuainain Fai A. , Tan Wei , Scott J. Brady , Roca Oriol , Mauri Tommaso 
Published: February 2023

AbstractBackgroundDuring high-flow nasal cannula (HFNC) therapy, flow plays a crucial role in the physiological effects. However, there is no consensus on the initial flow settings and subsequent titration. Thus, we aimed to systematically synthesize the effects of flows during HFNC treatment.MethodsIn this systematic review, two investigators independently searched PubMed, Embase, Web of Science, Scopus, and Cochrane for in vitro and in vivo studies investigating the effects of flows in HFNC treatment published in English before July 10, 2022. We excluded studies that investigated the pediatric population (< 18 years) or used only one flow. Two investigators independently extracted the data and assessed the risk of bias. The study protocol was prospectively registered with PROSPERO, CRD42022345419.ResultsIn total, 32,543 studies were identified, and 44 were included. In vitro studies evaluated the effects of flow settings on the fraction of inspired oxygen (FIO2), positive end-expiratory pressure, and carbon dioxide (CO2) washout. These effects are flow-dependent and are maximized when the flow exceeds the patient peak inspiratory flow, which varies between patients and disease conditions. In vivo studies report that higher flows result in improved oxygenation and dead space washout and can reduce work of breathing. Higher flows also lead to alveolar overdistention in non-dependent lung regions and patient discomfort. The impact of flows on different patients is largely heterogeneous.InterpretationIndividualizing flow settings during HFNC treatment is necessary, and titrating flow based on clinical findings like oxygenation, respiratory rates, ROX index, and patient comfort is a pragmatic way forward.
Distinct DNA methylation signatures associated with blood lipids as exposures or outcomes among survivors of childhood cancer: a report from the St. Jude lifetime cohort
Authors: Dong Qian , Chen Cheng , Song Nan , Qin Na , Plonski Noel-Marie , Finch Emily R. , Shelton Kyla , Easton John , Mulder Heather , Plyer Emily , Neale Geoffrey , Walker Emily , Li Qian , Huang I-Chan , Zhang Jinghui , Wang Hui , Hudson Melissa M. , Robison Leslie L. , Ness Kirsten K. , Wang Zhaoming 
Published: February 2023

Abstract
Background
DNA methylation (DNAm) plays an important role in lipid metabolism, however, no epigenome-wide association study (EWAS) of lipid levels has been conducted among childhood cancer survivors. Here, we performed EWAS analysis with longitudinally collected blood lipid data from survivors in the St. Jude lifetime cohort study.

Methods
Among 2052 childhood cancer survivors of European ancestry (EA) and 370 survivors of African ancestry (AA), four types of blood lipids, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TG), were measured during follow-up beyond 5-years from childhood cancer diagnosis. For the exposure EWAS (i.e., lipids measured before blood draw for DNAm), the DNAm level was an outcome variable and each of the blood lipid level was an exposure variable; vice versa for the outcome EWAS (i.e., lipids measured after blood draw for DNAm).

Results
Among EA survivors, we identified 43 lipid-associated CpGs in the HDL (n = 7), TC (n = 3), and TG (n = 33) exposure EWAS, and 106 lipid-associated CpGs in the HDL (n = 5), LDL (n = 3), TC (n = 4), and TG (n = 94) outcome EWAS. Among AA survivors, we identified 15 lipid-associated CpGs in TG exposure (n = 6), HDL (n = 1), LDL (n = 1), TG (n = 5) and TC (n = 2) outcome EWAS with epigenome-wide significance (P < 9 × 10−8). There were no overlapping lipids-associated CpGs between exposure and outcome EWAS among EA and AA survivors, suggesting that the DNAm changes of different CpGs could be the cause or consequence of blood lipid levels. In the meta-EWAS, 12 additional CpGs reached epigenome-wide significance. Notably, 32 out of 74 lipid-associated CpGs showed substantial heterogeneity (Phet < 0.1 or I2 > 70%) between EA and AA survivors, highlighting differences in DNAm markers of blood lipids between populations with diverse genetic ancestry. Ten lipid-associated CpGs were cis-expression quantitative trait methylation with their DNAm levels associated with the expression of corresponding genes, out of which seven were negatively associated.

Conclusions
We identified distinct signatures of DNAm for blood lipids as exposures or outcomes and between EA and AA survivors, revealing additional genes involved in lipid metabolism and potential novel targets for controlling blood lipids in childhood cancer survivors.