bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of extended home care on nursing compliance and quality of life in children with nephrotic syndrome
Authors: Wang Ying , Liu Fang , Ni Danhong , Liu Jingjing 
Published: July 2023

Abstract
Background: Nephrotic syndrome is characterized by a prolonged course, easy recurrence, multiple comorbidities and difficult care. Children with nephrotic syndrome have good compliance during hospitalization due to medical supervision, but often fail to implement care plans well after discharge.
Objective: To investigate the effect of continuous home care on nursing compliance, immune function and quality of life of children with nephrotic syndrome.
Methods: Ninety-eight cases of discharged children with nephrotic syndrome admitted to our hospital from January 2020 to January 2023 were selected for retrospective analysis. The children were divided into 54 cases in the observation group and 54 cases in the comparison group according to the different nursing programs. The observation group used the continuous home care model for the assessment of nursing problems, care and effect evaluation, while the comparison group used the conventional pre-discharge health education and regular telephone follow-up after discharge. The children in both groups were compared in terms of nursing care compliance, immune function and quality of life.
Results: The compliance rate of diet, fluid intake, medication, dialysis regimen, daily life, and exercise was higher in the observation group than in the control group, and the difference was statistically significant (P<0.05). The observation group had higher disease cognitive ability, disease-related behaviors, beliefs about the disease and overall scores than the control group after care, and the difference was statistically significant (P<0.05). The quality-of-life index scores of children in both groups were higher than those before care, and the scores of behavioral ability, physical function, psychological function and social function of children in the observation group were higher than those in the control group after care, and the difference was statistically significant (P<0.05).
Conclusion: Continuing home care for children with nephrotic syndrome can effectively improve the satisfaction level of children's quality of life, especially in family life, self-awareness and compliance with care.
Host susceptibility and fungal virulence in the wheat-Parastagonospora nodorum interactions
Authors: Choupannejad Roya , Sharifnabi Bahram , Collemare Jérôme , Massah Amir , Gholami Javad , Mehrabi Rahim 
Published: July 2023

Abstract
The fungus Parastagonospora nodorum is responsible for substantial economic losses of wheat worldwide. P. nodorum secretes multiple proteinaceous host-specific toxins known as necrotrophic effectors (NE) that induce compatible interactions with hosts possessing the corresponding dominant susceptibility (S) genes. In this study, the reaction of 40 wheat genotypes including 19 Iranian cultivars, 16 world cultivars and five differential genotypes against 33 P. nodorum isolates was investigated. In addition, the occurrence of known NEs and their corresponding S genes was assessed. Wheat genotypes were classified into six groups based on their variable reaction towards P. nodorum isolates. The S gene Tsn1 was present in 70% of highly susceptible cultivars and was completely absent in all resistant cultivars. The cultivars possessing all three S genes Tsn1, Snn1 and Snn3 were susceptible to all P. nodorum isolates. S gene Snn3 was detected in all Iranian wheat cultivars whereas the proportion of this gene in world cultivars was 62.5%. SnTox1-Snn1 was the most abundant NE-S gene frequency (100%) in Iranian P. nodorum isolates and Iranian cultivars. Furthermore, SnToxA was produced in Pichia pastoris and infiltration of SnToxA resulted in necrosis response exclusively on wheat cultivars harboring the Tsn1 sensitivity gene indicating that toxin infiltration can be used as a quick and accurate assay in breeding programs. Overall, these findings extended our substantial knowledge about P. nodorum-wheat interactions and their underlying molecular basis in Iran, a country located in the Fertile Crescent where both wheat and its pathogens coevolved.
Development and Interpretation of a Novel Nomogram for the Prognosis of Adult Metastatic Adrenocortical Carcinoma: A Retrospective Cohort Study
Authors: Huang Yi , Xie Weibin , zou Yitong , Hu Jintao , Liao Chengxiao , Yao Yuhui , Gan Qinghua , Kong Jianqiu , Fan Xinxiang 
Published: July 2023

Abstract
Purpose
To predict the prognosis of patients with metastatic adrenocortical carcinoma (mACC) and improve overall survival, we developed and validated a nomogram for predicting survival outcomes.
Methods
Adult metastatic patients were selected between 2000 and 2019 from Surveillance, Epidemiology, and End Results Program (SEER). Independent risk factors were identified by univariate and multivariate cox regression analysis. Overall survival was calculated by Kaplan–Meier. C-index, the area under the receiver operating characteristics curve (AUC) and calibration curve were employed to validate the model.
Results
A total of 336 mACC patients were included and randomly divided into training cohort (N = 235) and validation cohort (N = 101). The nomogram, based on independent chemotherapy and surgery predictors, exhibited favorable discrimination with C-index values of 0.704 and 0.702 for the training and validation cohorts, respectively. The AUC and calibration curve indicated favorable performance in both cohorts.
Conclusion
We constructed and validated a novel prognostic nomogram for mACC patients by incorporating chemotherapy and surgery, which assist clinical doctors to choose optimal clinical decision and improve the overall survival of mACC patients. In the future, chemotherapy combined with surgery or other may be recommended as first-line therapy for mACC patients.
The clinical value of preoperative 3D planning and 3D surgical guides for Imhäuser osteotomy in Slipped Capital Femoral Epipysis: a retrospective study
Authors: lagerburg vera , BOORN Michelle DEN , VORRINK Sigrid , AMAJJAR Ihsane , Witbreuk Melinda 
Published: July 2023

Abstract
Background Accurate repositioning of the femoral head in patients with Slipped Capital Femoral Epiphysis (SCFE) undergoing Imhäuser osteotomy is very challenging. The objective of this study is to determine if preoperative 3D planning and a 3D-printed surgical guide improve the accuracy of the placement of the femoral head.Methods This retrospective study compared outcome parameters of patients who underwent a classic Imhäuser osteotomy from 2009 to 2013 with those who underwent an Imhäuser osteotomy using 3D preoperative planning and 3D-printed surgical guides from 2014 to 2021. The primary endpoint was improvement in Range of Motion (ROM) of the hip. Secondary outcomes were radiographic improvement (Southwick angle), patient-reported clinical outcomes regarding hip and psychosocial complaints assessed with two questionnaires and duration of surgery.Results In the 14 patients of the 3D group radiographic improvement was slightly greater and duration of surgery was slightly shorter than in the 7 patients of the classis Imhäuser group. No difference was found in the ROM, and patient reported clinical outcomes were slightly less favourable.Conclusions Surprisingly we didn’t find a significant difference between the two groups. Further research on the use of 3D planning an 3D-printed surgical guides is needed.Trial registration Approval for this study was obtained of the local ethics committees of both hospitals.
Improvement of response bandwidth of Rydberg Receiver using an atomic array
Authors: Hu Jinlian , Jiao Yuechun , He Yunhui , Chen Teyan , Yu Xiongbin , Zhang Hao , Zhang Linjie , Zhao Jianming , Jia Suotang 
Published: July 2023

Abstract
We investigate the response bandwidth of a superheterodyne Rydberg receiver at a room-temperature vapor cell, and present an architecture of atomic array to increase the response bandwidth. Two microwave fields, denoted as a local oscillator (LO) ELO and a signal field ESig, couple two Rydberg states transition of |52D5/2⟩ → |53P3/2⟩. In the presence of the LO field, the frequency difference between two fields can be read out as an intermediate frequency (IF) signal using Rydberg electromagnetically induced transparency (EIT) spectroscopy. The bandwidth of the Rydberg receiver is obtained by measuring the output power of IF signal versus the frequency difference between two fields. The bandwidth dependence on the Rabi frequency of excitation lasers is presented, which shows the bandwidth decrease with the Rabi frequency of probe laser, while it is quadratic dependence on the Rabi frequency of coupling laser. Meanwhile, we investigate the effect of probe laser waist on the bandwidth, showing that the bandwidth is inversely proportional to the laser waist. We achieve a maximum response bandwidth of the receiver about 6.8~MHz. Finally, we design an architecture of atomic array for increasing the response and keeping the sensitivity, simultaneously. Our work has the potential to extend the applications of Rydberg atoms in communications.
Analysis of preoperative nutrition, immunity and inflammation correlation index on the prognosis of upper tract urothelial carcinoma surgical patients: a retrospective single center study
Authors: Ou Yong , Li Xinglan , Zheng Yang , Hu Xu , Bao Yige , Wang Dong , Chen Zhengjun , Ren Shangqing 
Published: July 2023

Abstract
Background: SII, PNI, SIRI, AAPR, and LIPI are prognostic scores based on inflammation, nutrition, and immunity. The purpose of this study was to examine the prognostic value of the SII, PNI, SIRI, AAPR, and LIPI in patients with UTUC who underwent radical nephroureterectomy with bladder cuff excision.
Materials and methods: Data of UTUC patients in Sichuan Provincial People's Hospital from January 2017 to December 2021 were collected. The optimal critical values of SII, PNI, SIRI, and AAPR were determined by ROC curve, and LIPI was stratified according to the dNLR and LDH. The Kaplan-Meier method was used to draw the survival curve, and Cox proportional hazard model was used to analyze the factors affecting the prognosis of UTUC patients.
Results: A total of 81 patients with UTUC were included in this study. The optimal truncation value of PNI , SII, SIRI and AAPR were determined to be 48.15, 596.4, 1.45 and 0.50, respectively. Univariate Cox proportional hazard regression showed that low PNI, high SII, high SIRI, low AAPR and poor LIPI group were effective predictors of postoperative prognosis of UTUC patients. Multivariate Cox proportional hazard regression showed that high SII was an independent risk factor for postoperative prognosis of UTUC patients. According to ROC curve, the prediction efficiency of fitting indexes of PNI, SII, SIRI, AAPR and LIPI is better than that of using them alone.
Conclusions: The SII, PNI, SIRI, AAPR, and LIPI was a potential prognostic predictor in UTUC patients who underwent radical nephroureterectomy with bladder cuff excision.
Inhibition of glutaminase suppresses the proliferation and invasion of esophageal squamous cancer cells via TGF-β/Smad and MAPK signaling pathways
Authors: Zhang Xiu , Wang Tao , Chen Yu , Huang Ming-de , Chen Kai 
Published: July 2023

Abstract
Accumulating evidence indicates that through its conversion of glutamine to glutamate, glutaminase (GLS) serves as a crucial player in cell proliferation and survival of different cancers. Nonetheless, the roles and mechanisms of GLS in esophageal squamous cancer have not been elucidated. Herein, we found that kidney-type GLS was overexpressed in glutamine-dependent esophageal squamous cell carcinoma (ESCC) cells and tissues. In addition, high GLS expression levels were related to a shorter survival rate than low GLS expression levels. Furthermore, knocking down GLS diminished the proliferation, migration, and invasion of ESCC cells and promoted their apoptotic rate and epithelial mesenchymal transformation (EMT) via the TGF-β/Smad canonical pathway and the TGF-β noncanonical MAPK pathway. Overall, our study showed that GLS is a therapeutic target and diagnostic biomarker for ESCC.
Global Mosquito Observations Dashboard (GMOD): a user-friendly web interface fueled by citizen science to monitor invasive and vector mosquitoes
Authors: Uelmen Johnny A. , Clark Andrew , Palmer John , Kohler Jared , Dyke Landon C. Van , Low Russanne , Mapes Connor D. , Carney Ryan M. 
Published: July 2023

Abstract
Background: Mosquitoes and the diseases they transmit pose a significant public health threat worldwide, causing more fatalities than any other animal. To effectively combat this issue, there is a need for increased public awareness and mosquito control campaigns. However, traditional surveillance programs are time-consuming, expensive, and lack scalability. Fortunately, the widespread availability of mobile phones with high-resolution cameras presents a unique opportunity for mosquito surveillance. In response to this, the Global Mosquito Observations Dashboard (GMOD) was developed as a free, public platform to improve the detection and monitoring of invasive and vector mosquitoes through citizen science participation worldwide.
Methods: GMOD is an interactive web interface that collects and displays mosquito observation and habitat data submitted by citizen scientists worldwide. By providing information on the locations and times of observations, the platform enables the visualization of mosquito population trends and ranges. It also serves as an educational resource, encouraging collaboration and data sharing. The data acquired and displayed on GMOD is freely available in multiple formats and can be accessed from any device with an internet connection.
Results: Since its launch less than a year ago, GMOD has already proven its value. It has successfully collected and processed large volumes of real-time data (~300,000 observations), offering valuable and actionable insights into mosquito species prevalence, abundance, and potential distributions, as well as engaging citizens in community-based surveillance programs.
Conclusions: GMOD is a cloud-based platform that provides open access to mosquito vector data obtained from citizen science programs. Its user-friendly interface and data filters make it valuable for researchers, mosquito control personnel, and other stakeholders. With its expanding data resources and the potential for machine learning advancements, GMOD is poised to support public health initiatives aimed at reducing the spread of mosquito-borne diseases in a cost-effective manner, particularly in regions where traditional surveillance methods are limited. GMOD is continually evolving, with ongoing development of powerful machine learning algorithms to identify mosquito species and other features from submitted data. The future of citizen science and artificial intelligence holds great promise, and GMOD stands as an exciting initiative in this field.
Progress towards one health approach for dog-mediated human rabies elimination in Bangladesh: on the way to zero by 30
Authors: Ghosh Sumon , Hasan Mohammad , Nath Nirmalendu , Haider Najmul , Jones Daleniece Higgins , Islam Md. , Rahaman M. Mujibur , Mursalin Hasan , Mahmud Nadim , Kamruzzam Md. , Rabby Md. Fazlay , Kar Shotabdi , Ullah Sayed , Shah Md. Rashed , Jahan Afsana , Rana Md. Sohel , Chowdhury Sukanta , Uddin Md. Jamal , Sunil Thankam , Ahmed Be-Nazir , Siddiqui Umme , Kaisar S. M. Golam , Islam Md. Nazmul 
Published: July 2023

Abstract
Bangladesh is making progress toward achieving zero human dog-mediated rabies deaths by 2030, a global goal set in 2015. We conducted a comprehensive analysis between the years 2011 to 2023 to understand the effectiveness of rabies control programmes and predict human rabies cases in Bangladesh by 2030 using time-series forecasting models. The human-to-dog ratio in Bangladesh was found to be 85.83, with an average dog population density of 11.51 dogs/km2. The mass dog vaccination (MDV) campaign has resulted in the vaccination of 81.46% of the estimated 3,030,662 dogs in the country. A decreasing trend from predicted and observed human rabies cases was identified, and it is projected that Bangladesh will have zero human rabies cases by 2030 if the current trend persists. The phylogenetic analysis shows that rabies viruses in Bangladesh belong to the Arctic-like-1 group. Bangladesh's efforts demonstrate that eliminating dog-mediated human rabies is achievable with a One Health approach.
Exploring the relationship between frequent cannabis use, vocal changes and language use
Authors: Olah Julianna , Chesney Edward , Oliver Dominic , Obreshkova Stiliyana , Wang Simiao , Cartier Megan , Gibbs-Dean Toni , Cummins Nicholas , Diederen Kelly , Englund Amir , Spencer Tom 
Published: July 2023

Abstract
Background
Cannabis use is prevalent among individuals with psychosis and a significant risk factor for the development of psychotic disorders, leading to unfavorable outcomes. Speech changes are frequently examined in psychotic disorders and connected to clinical outcomes. However, limited research investigated the impact of cannabis use on speech, which could potentially be a crucial confounding factor in the observed speech changes associated with psychosis. This study explores the differences in speech between frequent cannabis users and matched non-users.
Methods
Eight-minute speech samples from frequent cannabis users (N=82) and non-users (N=82) matched for gender, age, and education were manually transcribed and analyzed. Differences in vocal, semantic, and speech connectivity features were examined using T-tests. Logistic regression and random forest classifiers were employed to evaluate the discriminatory power of speech features.
Results
Acoustic, semantic and connectivity measures of speech showed significant differences between groups. Frequent cannabis users exhibited more voice breaks and back vowels. Connectivity analysis revealed more one-word loops in the cannabis group. Frequent users used more words, spoke coherently, and stayed on topic. Using logistic regression and random forest classifiers, participants were classified into cannabis or non-user groups with 0.66 / 0.72 accuracy (AUC = 0.62 / 0.69) based on demographic information and speech features.
Conclusions
Cannabis use is associated with alterations in speech features that overlap with those observed in psychosis. Consequently, understanding and potentially accounting for the effects of cannabis use on speech would be crucial for facilitating the treatment of psychotic disorders through speech analysis.
hPL-human adipose-derived stem cells in IKVAV-functionalised hydrogel conduit (Biogelx): an innovative delivery strategy to improve peripheral nerve repair
Authors: Guiotto Martino , Clayton Alison , Morgan Ryan , Raffoul Prof Wassim , Hart Prof Andrew , Riehle Mathis , Summa Prof Pietro di 
Published: July 2023

AbstractBackground.Adipose-derived stem cells (ADSC) are nowadays one of the most exploited cells in regenerative medicine. They are fast growing, capable of enhancing axonal elongation, support and locally stimulate Schwann cells (SC) and protect de-innervated muscles from atrophy after a peripheral nerve injury.Methods.With the aim of developing a bio-safe, clinically translatable cell-therapy, we assessed the effect of ADSC pre-expanded with human platelet lysate (hPL) in anin vivorat model, delivering the cells into a 15 mm critical-size sciatic nerve defect embedded within a laminin-peptide-functionalised hydrogel (Biogelx-IKVAV) wrapped by a poly--caprolactone (PCL) nerve conduit.Results.ADSC retained their stemness, their immunophenotype and proliferative activity when testedin vitro. At six weeks post implantation, robust regeneration was observed across the critical-size gap as evaluated by both the axonal elongation (anti-NF 200) and SC proliferation (anti-S100) within the Biogelx-IKVAV filled PCL conduit. All the other experimental groups manifested significantly lower levels of growth cone elongation. The histological gastrocnemius muscle analysis was comparable with no quantitative significant differences among the experimental groups.Conclusion.Taken together, these results suggest that ADSC encapsulated in Biogelx-IKVAV are a potential path to improve the efficacy of nerve regeneration. New perspectives can be pursued for the development of a fully synthetic bioengineered nerve graft for the treatment of peripheral nerve injury.
HULTIG-C: NLP Corpus and Services in the Cloud
Authors: Pais Sebastião , Cordeiro João , Jamil Muhammad 
Published: July 2023

Abstract
Nowadays, the use of language corpora for many purposes has increased significantly. General corpora exist for numerous languages, but research often needs more specialized corpora. The Web’s rapid growth has significantly improved access to thousands of online documents, highly specialized texts and comparable texts on the same subject covering several languages in electronic form. However, research has continued to concentrate on corpus annotation instead of corpus creation tools. Consequently, many researchers create their corpora, independently solve problems, and generate project-specific systems. The corpus construction is used for many NLP applications, including machine translation, information retrieval, and question-answering. This paper presents a new NLP Corpus and Services in the Cloud called HULTIG-C. HULTIG-C is characterized by various languages that include unique annotations such as keywords set, sentences set, named entity recognition set, and multiword set. Moreover, a framework incorporates the main components for license detection, language identification, boilerplate removal and document deduplication to process the HULTIG-C. Furthermore, this paper presents some potential issues related to constructing multilingual corpora from the Web.
Telemedicine for Monitoring Nutritional Intake in Malnourished Community-Dwelling Elderly: A Scoping Review of Clinical Trials
Authors: Saputro Bryanna Infinita L. , Dhiya Rakasiwi Muhammad Ilham , KhairaniSiregar Astrid Mariam 
Published: July 2023

Malnutrition is part of the geriatric giant and a major concern among community-dwelling elderly individuals. Improper intervention of this problem can have detrimental effects on the elderly. Monitoring nutritional intake plays a vital role in managing malnutrition. Telemedicine has been widely applied for managing chronic diseases and gained prominence during the COVID-19 pandemic as a remote health monitoring method. This scoping review aims to identify the advantages and limitations of implementing telemedicine for addressing malnutrition in community-dwelling elderly. This study reviewed the literature obtained through a systematic search of PubMed and ScienceDirect databases, supplemented by manual searches based on specific inclusion criteria. Two randomized controlled trials (RCTs) assessing the application of telemedicine for malnutrition were identified. The forms of telemedicine used were telecare and set-top boxes on television. The interventions included nutritional monitoring and specific interventions for each patient. However, high patient dropout rates indicated low patient compliance. Nevertheless, the application of telemedicine demonstrated improved patient compliance with nutritional intake guidelines. Limitations of telemedicine implementation included low motivation, technological constraints, and physiological constraints. Telemedicine may be used as a tool for monitoring nutritional intake among malnourished geriatric populations.