bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and Properties of the WSCR/PVDF Hybrid Ultrafiltration
Authors: dong yanmao 
Published: June 2023

Abstract
The wide use of selective catalytic reduction (Selective Catalytic Reduction, SCR) technology produces a large number of waste SCR catalysts (waste selective catalytic reduction, WSCR). In order to reuse WSCR, an organic-inorganic hybrid ultrafiltration membrane (PVDF/WVCR) was prepared from WSCR and polyvinylidene fluoride (PVDF). WSCR was analyzed by scanning electron microscope with energy dispersive spectrometer (SEM-EDS), X-ray powder diffraction (XRD) instrument, Fourier transform infrared spectroscopy (FTIR). Results showed that the particle size of WSCR was 5-40 μm and contained elements including O, Ti, Si, Ca, Al, Mo, Fe and V. WSCR hybrid PVDF (PVDF/WSCR) ultrafiltration membrane was prepared by blending method, and the effect of the amount of WSCR on membrane properties was investigated. The contact angle of PVDF/WSCR was smaller than that of pure PVDF. The hydrophilicity of the PVDF/WSCR membrane was enhanced by WSCR.The humic acid retention of PVDF/WSCR reached 78%. The results provide new ideas for reuse WSCR to reduce the cost of ultrafiltration membrane and improve the performance of PVDF ultrafiltration membrane.
Effectiveness of a Hysteroscopic Tissue Removal System Device for Hysteroscopic Myomectomy on Patients’ Quality of Life: A Randomized Clinical Trial
Authors: TAM Teresa , JUAREZ Lourdes 
Published: June 2023

Abstract
Purpose: To evaluate the quality of life in patients treated for submucosal leiomyomas after hysteroscopic myomectomy compared to medical therapy. This is the first prospective randomized analysis comparing outcomes of medical therapy versus hysteroscopic myomectomy using the TruClear™ hysteroscopic tissue removal system to treat heavy menstrual bleeding from submucosal leiomyoma(s).
Methods: Setting: private practice and community-based hospital; subjects: female patients with symptomatic submucosal leiomyomas from 2014-2017. A total of 69 patients enrolled, with 47 completed. Statistical analysis used: randomized clinical trial. Each patient was randomized to oral contraceptive pills/progesterone releasing intrauterine device or hysteroscopic myomectomy. Each patient was to complete the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) questionnaire at baseline, one month, three months, and greater than or equal to six months after treatment. Main outcome measured: Primary outcome was the health-related quality of life (HR-QOL), as reflected from UFS-QOL scores. Contrasts were constructed from a linear mixed-effects model to compare the two treatment groups for changes from baseline in UFS-QOL scores.
Results: UFS-QOL scores were similar at baseline between the two treatment groups. There was an overall improvement in all UFS-QOL scores within each group. Higher improvement scores were noted in the surgical group compared to the medical group for almost all UFS-QOL scores. At ≥6 months, in comparison to the medically managed patients, the most considerable score improvements for the surgical group were reported in HR-QOL concern, activities, self-consciousness and symptom severity scores having mean change scores (95% CIs) of 35.3, 28.9, 28.6, and 32.2, respectively.
Conclusion: Although there was no statistical difference in the change degree of improvement of overall quality of life among patients with symptomatic submucosal leiomyomas who received medical or surgical treatments in the study, there were greater differences in improvements in health-related quality of life scores over time after surgical treatment.
Does environmental water management promote invasive fish? Modelling the response of common carp (Cyprinus carpio) to natural and managed flows using a stochastic population model
Authors: Todd Charles Robert , Koehn John D , Stuart Ivor G , Wootton Henry F , Zampatti Brenton P , Thwaites Leigh , Conallin Anthony , Ye Qifeng , Stamation Kasey , Bice Chris 
Published: June 2023

Abstract

Common carp (Cyprinus carpio; hereafter carp) is a highly invasive freshwater fish that has colonised river basins across the world causing ecological degradation. In regulated rivers, restoration of natural flow regimes to rehabilitate aquatic ecosystems is a primary focus of environmental management, yet some actions (e.g., environmental water delivery or artificial floodplain inundations) may have unintended consequences including favouring carp. We developed a stochastic population model to represent carp population responses to hydrology and management actions. The model uses current understanding of carp life history, including different survival rates of early life-stages for a range of habitat types, to estimate population responses to various flow/inundation scenarios. Using case studies from two major regions of a large, regulated dryland river, we demonstrate that large natural floods and prolonged droughts accounted for the greatest amplitude of projected carp population increases and declines, respectively. Within-channel flow pulses and small floods, which are a primary focus of environmental flows, appeared to have little influence on long-term carp population trajectories. Artificial inundations generated by floodplain infrastructure, however, caused significant carp recruitment compared to baseline scenarios. Large natural floodplain inundations also maintained high carp biomasses and thus likely high impacts on natural ecological values. The carp population model captures the response of carp to flows and artificial floodplain inundation and will inform environmental managers on the likely trade-offs between achieving restoration of natural ecological values and suppressing a globally invasive fish.
A Bioinformatics-Based Analysis of an Anoikis-Related Gene Signature Predicts the Prognosis of Patients with pancreatic adenocarcinoma
Authors: Liu Xizhi , Gu Shanzhi , Zhao Xinhan , Zhang Yujiao 
Published: June 2023

Abstract
Background Anoikis acts as an important defense for the organism by preventing shedding tumor cells from re-adhering to incorrect locations and preventing their growth. In this study, anoikis-related genes (ARGs) were used to construct a prognostic model for PAAD patients.Methods TCGA database was used to acquire RNA sequencing data and clinical information for PAAD samples. The Cox regression analysis, LASSO regression were performed to construct the prognostic ARGs signature. In addition, GSEA, GO, KEGG were performed to investigate the potential molecular mechanism. Moreover, we analyzed the relationship between our identified signature and immune cell infiltration, tumor microenvironment, mutation landscape, immunotherapy response, drug sensitivity analysis.Results Two ARGs were slected, including MET and SLCO1B3. Finally, in vitro experiments we performed qRT-PCR, western blot, scratch test, colony-formation analysis to validate the expression and function of MET gene.Conclusion Combined with clinicopathological characteristics, the risk model was validated as a new independent prognostic factor for PAAD.
Non-Monotone Exponential Time (NEXT) Model for the Longitudinal Trend of a Continuous Outcome in Clinical Trials
Authors: Duan Ran , Chen Kaiyi , Du Yu , Kulkarni Pandurang , Qu Yongming 
Published: June 2023

Abstract
The dose response curve has been studied extensively for decades. However, most
of these methods ignore intermediate measurements of the response variable and only
use the measurement at the endpoint. In early phase trials, it is crucial to utilize all
available data due to the smaller sample size. Simulation studies have shown that the
longitudinal dose-response surface model provides a more precise parameter estima-
tion compared to the traditional dose response only using data from the primary time
point. However, the current longitudinal models with parametric assumptions assume
that the treatment effect increases monotonically over time, which may be controversial
to reality. We propose a parametric non-monotone exponential time (NEXT) model,
an enhanced longitudinal dose-response model with greater flexibility, capable of ac-
commodating non-monotonic treatment effect and making predictions for longer-term
efficacy. In addition, the estimator for the time to maximum treatment effect and its
asymptotic distribution has been derived from NEXT. Extensive simulation studies us-
ing known data-generating models and using real clinical data showed that the NEXT
model outperformed the existing monotone longitudinal models.
Local versus regional contributions to PM10 levels in the western Mediterranean
Authors: Clemente Álvaro , Galindo Nuria , Nicolás Jose F. , Crespo Javier , Pastor Carlos , Yubero Eduardo 
Published: June 2023

Abstract
In this study, PM10 daily samples were collected every day during approximately one month in winter and one month in summer, 2019. Sampling was performed simultaneously at two different locations: an urban traffic site (∼ 80 m a.s.l.) and a regional background station (∼ 1500 m a.s.l.) in the Western Mediterranean. The objective of this work was to investigate PM10 sources at both sites in order to determine regional and urban contributions to aerosol levels. Seven factors were obtained at both sites using Positive Matrix Factorization (PMF): Saharan dust, Aged sea salt, Ammonium sulfate, Nitrate, Road traffic, Local dust and Fresh sea salt. At the urban site, the contribution of vehicle related-sources (Road traffic, Nitrate and Local dust) was significantly higher in winter (∼80%) than in summer (∼60%).
Unusual photodynamic characteristics of light-oxygen-voltage domain of phototropin linked to terrestrial adaptation of Klebsormidium nitens
Authors: Sharma Sunita , Gautam Avinash , Gourinath samudrala , Kateriya Suneel 
Published: June 2023

Abstract
Phototropin (Phot), a blue light sensing LOV domain protein, mediates blue light responses and is evolutionary conserved across the green lineage. Klebsormidium nitens, a green terrestrial alga, presents a valuable opportunity in studying adaptive responses from aquatic to land habitat transitions. We determined the crystal structure of Klebsormidium nitens Phot LOV1 domain (KnLOV1) in the dark and engineered different mutations (R60K, Q122N, D33N) to modulate the lifetime of photo recovery cycle. We observed an unusual slow recovery in native KnLOV1 domain (τ = 2467 seconds) compared to different mutants (R60K: τ = 122 seconds, Q122N: τ = 101 seconds, D33N: τ = 580 seconds). Crystal structures of native KnLOV1 and mutants revealed subtle but critical changes near the protein chromophore that is responsible for modulating protein recovery rate. Our findings shed light on the unique structural characteristics of the newly studied KnLOV1 and its evolutionary importance for phototropin mediated physiology.
Fluid Dynamics Equations based on Constitutive Relation of Symmetric Shearing Deformation
Authors: Zhu Shuaichen , Wang Duo , Liu Yang , Xu Hongyi 
Published: June 2023

Abstract
The fluid kinematics of Liutex decomposes a velocity gradient tensor (VGT) of \(\nabla \vec {v}\) into four components, including rotation (\(\varvec{R}\)), stretching/compressing (\(\varvec{SC}\)), anti-symmetric shear (\({\varvec{S}_{anti - sym}}\)) and symmetric shear (\({\varvec{S}_{sym}}\)), as oppose to the traditional Cauchy-Stokes decomposition where a VGT was decomposed into the strain rate and vorticity tensors. The current study limpidly clarified the physical meanings of these deformations in the newly-proposed decomposition from the perspectives of both fluid kinematics and dynamics. With an in-depth understanding the physical connotations of these deformations, the present study further suggests that the \({\varvec{S}_{sym}}\) be the only deformation appropriately correlated to the stress tensor, leading to the establishment of a new constitutive relation for Newtonian fluids with the modified model assumptions originated from Stokes in 1845. Moreover, the present research finds that the “principal decomposition” proposed by Liu is not mathematically unique when a VGT possesses three real eigenvalues (TR). Within the context, a new decomposition method is introduced to resolve the non-uniqueness issue. Based on the modified Stokes assumptions and the associated VGT decomposition method, a set of new fluid dynamics momentum equations are obtained for Newtonian fluid. The added stress tensor of \({\varvec{F}^{add}}\) is identified as the key difference between the newly-derived governing equations and the conventional N-S equations, which is caused by excluding the \(\varvec{SC}\) correlation to the stress tensor in the new constitutive equation. Finally, a preliminary analysis of \({\varvec{F}^{add}}\) is conducted using the existing channel turbulence DNS data based on the traditional N-S equations. The \({\varvec{F}^{add}}\) is found widely existing in the flow field and is at the same order of magnitude with the other force terms in these equations. Therefore, the \({\varvec{F}^{add}}\) is expected to have some tangible effects on altering the current DNS data based on the traditional N-S equations, which will be further verified by performing the ‘DNS’ simulation using the newly-derived fluid dynamic equations in near future.
Nomogram with insufficient examined lymph node count to help T3N0M0 gastric cancer patients with adjuvant chemotherapy selection–a population-based study combined with external validation
Authors: Zhao Shutao , Zhang Chao , Wen Dacheng 
Published: June 2023

Abstract
Objective
Whether chemotherapy is required for T3N0M0 gastric cancer patients after surgery is controversial.
Methods
Using the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database, 420 patients with pT3N0M0 gastric cancer diagnosed after radical resection between 2004 and 2016 were screened for analysis. Survival analysis was performed using the Kaplan-Meier method and the log-rank test. Cox proportional hazards regression analysis was used to screen independent prognostic factors and build a nomogram survival prediction model. The patients were divided into three groups of low, moderate, and high risk using X-tile software according to the risk score. A total of 335 patients with pT3N0M0 gastric cancer diagnosed between 2000 and 2013 at our hospital were used for external validation.
Results
Multivariate analysis revealed that age, histology, and examined lymph node count were independent prognostic factors for pT3N0M0 gastric cancer in the group without adjuvant therapy and were therefore included in the nomogram prediction model. The concordance index for the nomogram model was 0.628 (95% confidence interval, 0.542–0.714). All patients were divided into three risk subgroups according to the nomogram prediction score. The analysis results showed that adjuvant chemotherapy did not improve the prognosis of low risk patients, while moderate and high risk patients benefited from it. External validation was consistent with the SEER database results.
Conclusion
The model demonstrated that only moderate and high risk patients were recommended to receive adjuvant chemotherapy, while low risk patients were not.
WITHDRAWN: Effect of Silicon and Certain Bio-Fertilizers in Inducing Defense in Rice Against Rice Leaf Folder
Authors: Dash S. , Rath L. K 
Published: June 2023

Abstract
Field experiments conducted during kharif, 2016 through 2017 to evaluate the induced defense effect of silicon applied through inorganic and organic sources on rice against leaf folder revealed that silicon taken by rice plants in various treatments reduced the leaf folder infestation as compared to control treatment. The treatment RHA + PF + KSB(T8) was the most effective treatment in reducing infestation followed by CaSiO3 + PF + KSB(T5) and CaSiO3 + KSB(T4), respectively. Silicon content was observed to be more in T5 followed by T4 and T8 treatments. Proline accumulation was lowest in T5 followed by T8 and T3 (CaSiO3 + PF) treatments. The phenol content was highest in T5 followed by T8 and T4 treatments, respectively. The total protein content was lowest in T5 followed by T4 and T8 treatments. The grain yield was highest in T5 (4473.83 kg/ha) followed by T8(4173.33 kg/ha) and T4 (4103.17 kg/ha). Application of both inorganic and organic source of silicon in various combinations exercised induced defense mechanism in rice against leaf folder infesting rice.
Effects of temperature and humidity on cerebrovascular disease hospitalization in a super- aging society
Authors: Doi Shunichi , Yoneyama Kihei , Yoshida Toshiya , Kawagoe Yasuhito , Nakai Michikazu , Sumita Yoko , Ishibashi Yuki , Izumo Masaki , Tanabe Yasuhiro , Harada Tomoo , Akashi Yoshihiro J. 
Published: June 2023

Abstract
Weather conditions influence the incidence of cardiovascular disease. However, few studies shown the association of weather temperature and humidity with cerebrovascular disease hospitalizations in a super-aging society. We included 606,807 consecutive patients with cerebrovascular disease admitted to Japanese acute-care hospitals between 2015 and 2019. The primary outcome was the number of cerebrovascular disease hospitalizations per day. Multilevel mixed-effects linear regression models were used to estimate the association of mean temperature and humidity, 1 day before hospital admission, with cerebrovascular disease hospitalizations, after adjusting for air pollution, hospital, and patient demographics. Lower mean temperatures and humidity < 70% or humidity ≧ 70% are associated with an increased incidence of cerebrovascular disease hospitalization (coefficient, -1.442 [-1.473 to -1.411] per ℃, p < 0.001, coefficient, -0.084 [-0.112 to -0.056] per%, p < 0.001, and coefficient, 0.136 [0.103 to 0.168] per %, p < 0.001, respectively). Lower mean temperatures and extremely low or high humidity are associated with an increased incidence of cerebrovascular disease hospitalization in the super-aging society.
Scale-free network reveals relations between quantum computing and Barrow entropy
Authors: Bousder M. , Sakhi Z. 
Published: June 2023

Abstract
The scale-free network in the black hole horizon gives rise to Barrow entropy behavior, which can be visualized geometrically through the Farey diagram. We perform a detailed analysis to demonstrate the quantified values of Barrow entropy. We calculate the black hole entropy by using the Mertens function with the Farey sequence. We use the black hole network to create a register of quantum computers by applying controlled-NOT gates and use quantum entanglement for data transmission and retrieval. We propose a scenario of Hawking radiation according to the Farey background.
Magnetically controlled graphene field-effect transistor biosensor for highly sensitive detection of cardiac troponin I
Authors: Zhu Xiaofeng , Cheng Kangning , Ding Yue , Liu Huanqing , Xie Shuqi , Cao Yuwei , Yue Weiwei 
Published: June 2023

Abstract
Herein, we have constructed a magnetic graphene field-effect transistor biosensor for highly sensitive detection of cardiac troponin I (CTNI). Graphene film was used as a conductive channel and transferred onto a glass substrate with two indium tin oxide (ITO) electrodes. CTNI aptamer was immobilized onto the graphene film via 1-pyrene-butanoic acid succinimidyl ester (PBASE) to capture CTNI. Magnetic nanobeads modified with CTNI antibody were added to the reaction chamber to form an aptamer/CTNI/antibody/magnetic nanobeads sandwich-type complex. By applying a periodic magnetic field, we found that the magnetic force exerted on the complex leads to an impedance change of the graphene film. The results were rationalized using a model wherein the magnetic force causes the CTNI aptamer strand to bend, thereby resulting in magnetic nanobeads/CTNI aptamer modulation of the double conductive layer of graphene transistors. With periodic sampling integration, different concentrations of CTNI can be detected with high sensitivity. Due to the specific binding property of the aptamer to the antigen, the magnetic graphene field-effect transistor biosensor can be used for the specific detection of different kinds of proteins and can potentially be a detection tool for DNA, specific cells, etc.
Trainee Autonomy and Supervision in the Modern Clinical Learning Environment: A Mixed-Methods Study of Faculty and Trainee Perspectives
Authors: Conner Stephanie M. , Choi Nancy , Fuller Jessica , Daya Sneha , Barish Peter , Rennke Stephanie , Harrison James D. , Narayana Sirisha 
Published: June 2023

Abstract
Background: Balancing autonomy and supervision during medical residency is important for trainee development while ensuring patient safety. In the modern clinical learning environment, tension exists when this balance is skewed. This study aimed to understand the current and ideal states of autonomy and supervision, then describe the factors that contribute to imbalance from both trainee and attending perspectives.
Methods: A mixed-methods design included surveys and focus groups of trainees and attendings at three institutionally affiliated hospitals between May 2019-June 2020. Survey responses were compared using chi-square tests or Fisher’s exact tests. Open-ended survey and focus group questions were analyzed using thematic analysis.
Results: Surveys were sent to 182 trainees and 208 attendings; 76 trainees (42%) and 101 attendings (49%) completed the survey. Fourteen trainees (8%) and 32 attendings (32%) participated in focus groups. Trainees perceived the current culture to be significantly more autonomous than attendings; both groups described an “ideal” culture as more autonomous than the current state. Focus group analysis revealed five core contributors to the balance of autonomy and supervision: attending-, trainee-, patient-, interpersonal-, and institutional-related factors. These factors were found to be dynamic and interactive with each other. Additionally, we identified a cultural shift in how the modern inpatient environment is impacted by increased hospitalist attending supervision and emphasis on patient safety and health system improvement initiatives.
Conclusions: Trainees and attendings agree that the clinical learning environment should favor resident autonomy and that the current environment does not achieve the ideal balance. There are several factors contributing to autonomy and supervision, including attending-, resident-, patient-, interpersonal-, and institutional-related. These factors are complex, multifaceted, and dynamic. Cultural shifts towards supervision by primarily hospitalist attendings and increased attending accountability for patient safety and systems improvement outcomes further impacts trainee autonomy.
MV140 mucosal bacterial vaccine improves uropathogenic E. coli clearance in an experimental model of urinary tract infection
Authors: Ligon Marianne , Diez-Rivero Carmen , García-Ayuso Diego , Mohanty Soumitra , Conejero Laura , Brauner Annelie , Subiza José , Mysorekar Indira , Saz-Leal Paula 
Published: June 2023

Abstract
MV140 is a mucosal vaccine of inactivated whole bacteria (E. coli, K. pneumoniae, E. faecalis, P. vulgaris) with clinical efficacy against recurrent urinary tract infections (UTIs). Here, MV140 was evaluated in a murine model of acute uropathogenic E. coli (UPEC)-induced UTI using the UTI89 strain. MV140 vaccination resulted in UPEC clearance, concomitant with increased influx of myeloid cells in urine, CD4+ T cells in the bladder, and a systemic adaptive immune response to both MV140-containing E. coli and UTI89.