bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucagon-like peptide-1 and glucagon-like peptide-2 are potential regulators of lipid metabolism during human liver regeneration
Authors: Ammann Markus , Santol Jonas , Pereyra David , Kalchbrenner Tamara , Wuerger Tanja , Laengle Johannes , Smoot Rory L. , Hulla Wolfgang , Laengle Friedrich , Starlinger Patrick P. 
Published: July 2023

Abstract
Accumulating evidence suggests that metabolic demands of the regenerating liver are met via lipid metabolism and critical regulators of this process. As such, glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) critically affect hepatic regeneration in rodent models. The present study aimed to evaluate potential alterations and dynamics of circulating GLP-1 and GLP-2 in patients undergoing liver resections, focusing on post-hepatectomy liver failure (PHLF). GLP-1, GLP-2, Interleukin-6 (IL-6) and parameters of lipid metabolism were determined perioperatively in fasting plasma of 46 patients, who underwent liver resection. GLP-1 and GLP-2 demonstrated a rapid and consistently inverse time course during hepatic regeneration with a significant decrease of GLP-1 and increase of GLP-2 on POD1. Importantly, these postoperative dynamics were significantly more pronounced when PHLF occurred. Of note, the extent of resection or development of complications were not associated with these alterations. IL-6 mirrored the time course of GLP-2. Assessing the main degradation protein dipeptidyl peptidase 4 (DPP4) no significant association with either GLP-1 or -2 could be found. Additionally, in PHLF distinct postoperative declines in plasma lipid parameters were present and correlated with GLP-2 dynamics. Our data suggest dynamic inverse regulation of GLP-1 and GLP-2 during liver regeneration, rather caused by an increase in expression/release than by changes in degradation capacity and might be associated with inflammatory responses. Their close association with circulating markers of lipid metabolism and insufficient hepatic regeneration after liver surgery suggest a critical involvement during these processes in humans.
Population Attributable Fraction of poor sleep quality and its association with dementia: a Brazilian population-based study.
Authors: Borelli Wyllians Vendramini , Noll Giovani , Tonon André C , Leotti Vanessa Bielenfeldt , Chaves Márcia Lorena Fagundes , Zimmer Eduardo , Castilhos Raphael Machado 
Published: July 2023

Abstract
The populational impact of sleep quality and the risk of dementia is unclear. We analyzed the Population Attributable Fraction (PAF) of sleep parameters in a large-scale Brazilian cohort (ELSI-Brazil). A subset of the ELSI-Brazil with complete responses to sleep quality was selected. This is a large representative sample of the Brazilian elderly population with an extensive assessment of sociodemographic and health risk variables. Prevalence was estimated according to the complex sample design, and its PAF was measured using a meta-analytic relative risk. A total of 6024 (out of 9412) individuals had complete responses. The prevalence of poor sleep quality was 24.9% (95%CI 23–26%), and the PAF of poor sleep quality including 10 modifiable risk factors of dementia was 52% in Brazil. Sleep parameters varied considerably according to age ranges, race, and gender. Poor sleep quality appears to be an important populational risk factor for dementia in Brazil. Targeted interventions may provide an important impact in preventing dementia in low- and middle-income countries.
Intimate Partner Violence and Prenatal Oral Health Experiences
Authors: Testa Alexander , Lee Jacqueline , Jackson Dylan B. , Mungia Rahma , Ganson Kyle T. , Nagata Jason M. 
Published: July 2023

Abstract
Background:
Intimate partner violence (IPV) is a significant public health issue, and when experienced during pregnancy, IPV poses substantial harms for maternal health. Still, limited research has examined how IPV may influence prenatal oral health and dental care utilization. This study aims to investigate the relationship between IPV during pregnancy and women’s oral health experiences.
Data:
Data are from the Pregnancy Risk Assessment Monitoring System from 2016 through 2019 (N = 85,289). Multivariable logistic regression analyses were used to examine the association between physical IPV during pregnancy and various oral health experiences.
Findings:
Women who experienced prenatal physical IPV reported worse oral health experiences during pregnancy, including being more likely to report not knowing it was important to care for their teeth, not talking about dental health with a provider, needing to see a dentist for a problem, going to see a dentist for a problem, as well as having more unmet dental care needs.
Conclusions:
Together, these findings indicate that women who experience physical IPV during pregnancy have lower knowledge of prenatal oral health care, more oral health problems, and greater unmet dental care needs. Given the risk associated with IPV and oral health problems for maternal and infant health, the study findings point to greater attention toward the oral health needs of IPV-exposed pregnant women.
Determination of leachate leakage around a valley type landfill and its pollution and risk on groundwater
Authors: Xie Qing , Lu Yulong , Cao Chuanghua , Li Chenyang , Ren Bozhi , Liu Yang 
Published: July 2023

Abstract

Landfill leachate has great pollution risk to groundwater, which is of practical significance to study the characteristics of leachate leakage and surrounding groundwater pollution and its harm to human health. Taking a typical valley-type landfill in South China as the research object, this paper ascertained the leakage area based on geophysical methods and groundwater sampling. A total of 21 parameters such as pH, total hardness (TH), total mineralization (TM), permanganate index (CODMn), ammonium (NH3-N), nitrites (NO3-N), nitrates (NO2-N), sulphates (SO4−), chloride (Cl−), fluorides (F−), volatile phenols, cyanide, and heavy metals (HMs) in groundwater and some indicators in leachate were tested, and the water quality and health risks were evaluated by using the Nemerow pollution index (NPI) method and BCRA (Rish-based Corrective Action) model. The results indicate that the leakage areas are existing in the middle of the landfill site, the middle and the south of the anti-seepage dam with a depth about 15-22m and main pollutants of CODMn and NH3-N. The main pollutants of pH, NH3-N, Fe and Mn were ranged from 5.80 to 6.70, 0.06 to 0.74 mg/L, 0.002–2.763 mg/L, and 0.003–1.181 mg/L, their rates exceed the class Ⅲ standard at 28.57%, 28.57%, 4.29% and 14.29%, respectively. The Nemerow pollution index showed that the groundwaters at ZK01 and ZK04 were seriously polluted. Groundwater quality was affected by leachate and natural geological background. The total non-carcinogenic risk of groundwater was ranked as LS102 < LS101 < ZK02 < ZK01 < ZK03 < ZK05 < ZK04, with Cl− and Mn as the main non-carcinogenic pollutants in the landfill. This rank reveals the rule that the closer to the waste body, the higher the risk.
The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows
Authors: Schwerdtfeger Jessica , Sauerwein Helga , Albrecht Elke , Mazzuoli-Weber Gemma , Soosten Dirk , Dänicke Sven , Kuhla Björn 
Published: July 2023

Abstract
The endocannabinoid system (ECS) is involved in the regulation of fat and energy metabolism, but knowledge about its influence in early lactation of cows is scarce. The aim of the study was to investigate the effect of N-arachidonoylethanolamide (AEA), an endocannabinoid with orexigenic characteristics, on plasma endocannabinoid concentrations, feed intake, energy balance, lipomobilisation, and hepatic lipid metabolism of early-lactating dairy cows. The experiment involved 10 pairs of Holstein half-sibling cows (end of 2nd -3rd pregnancy). Half-sibs of each pair were randomly assigned to either AEA (n = 10) or control (CON) group (n = 10). The AEA group received repeated intraperitoneal injections of 3 µg/kg body weight AEA and the CON group 0.9% NaCl. In week 1 to 3 postpartum, AEA administration had no effect on dry matter intake, body weight, or lipomobilisation, but affected plasma triglyceride concentration and mRNA abundances of genes related to hepatic triglyceride synthesis. In week 4 postpartum, the AEA group showed reduced feed intake and whole-body carbohydrate oxidation, but increased whole-body fat oxidation and hepatic lipid accumulation, likely as a result of a counter-regulatory leptin increase. In conclusion, the present study shows a tissue-specific AEA insensitivity and may point to a leptin-controlled regulation of the ECS in early-lactation.
Breaking 1.7V open circuit voltage in large area transparent perovskite solar cells using bulk and interfaces passivation.
Authors: Matteocci Fabio , Girolamo Diego Di , Vidon Guillame , Barichello Jessica , Giacomo Francesco Di , Jafarzadeh Farshad , Paci Barbara , Generosi Amanda , Kim Minjin , Castriotta Luigi Angelo , Frégnaux Mathieu , Guillemoles Jean-François , Schulz Philip , Ory Daniel , Cacovich Stefania , Carlo Aldo Di 
Published: July 2023

Abstract
Efficient semi-transparent solar cells can trigger the adoption of building integrated photovoltaics. Halide perovskites are particularly suitable in this respect owing to their tunable bandgap. Main drawbacks in the development of transparent perovskite solar cells are the high Voc deficit and the difficulties in depositing thin films over large area substrates, given the low solubility of bromide and chloride precursors. In this work, we develop a 2D and passivation strategies for the high band-gap Br perovskite able to reduce charge recombination and consequently improving the open-circuit voltage. We demonstrate 1cm2 perovskite solar cells with Voc up to 1.73 V (1.83 eV QFLS) and a PCE of 8.2%. The AVT exceeds 70% by means of a bifacial light management and a record light utilization efficiency of 5.72 is achieved, setting a new standard for transparent photovoltaics. Moreover, we show the high ceiling of our technology towards IoT application due to a bifaciality factor of 87% along with 17% PCE under indoor lighting. Finally, the up-scaling has been demonstrated fabricating 20cm2-active area modules with PCE of 7.3% and Voc per cell up to 1.65V.
A Machine Learning Approach to Predict the S&amp;P 500 Absolute Percent Change
Authors: Somarriba F. , Norouzzadeh P. , Anwar Z. , Snir E. , Rahmani Bahareh 
Published: July 2023

Abstract
Models of the stock market often focus on predicting the direction of the stock market either up or down. Instead of following that approach, this paper created a model for daily absolute percent change of the S&P 500. An accurate model of this metric would greatly increase profitability of option trading strategies such as straddles and iron condors. In this publication, novel features were created based on historical data and fed to machine learning algorithms such as Decision Trees, Rule Based Classifiers, K-mean Clusters, and Kernels. Based on our findings, Decision Trees and Kernels showed an accuracy of 80% when predicting Absolute Percent change, while Rule Based Classifiers had an accuracy of 88% and a 38% coverage of the data.
Optimising Resource Consumption and Reducing Power Usage in datacentres: A Mathematical VM Replacement Model and Efficient Algorithm
Authors: Rabieyan Reza , Yahyapour Ramin 
Published: July 2023

Abstract

This study addresses the issue of power consumption in virtualized cloud datacentres by proposing a VM replacement model and an efficient algorithm. The model incorporates multi-objective functions, aiming to optimise VM selection based on weight and minimise resource utilisation disparities across hosts. Constraints are included to maintain balanced CPU, memory, and network bandwidth usage. The proposed algorithm offers a fast solution with minimal VM replacements. Experimental results in a simulation environment demonstrate significant reductions in power consumption compared to alternative models. The proposed model and algorithm are successfully implemented and operated within a real-world cloud infrastructure, emphasising their practicality.
Characterization and Regulation of Salt Upregulated Cyclophilin from a Halotolerant Strain of Penicillium oxalicum
Authors: Singh Mangaljeet , Singh Harpreet , Kaur Kirandeep , . Shubhankar , Singh Supreet , Kaur Amarjeet , Singh Prabhjeet 
Published: July 2023

AbstractPenicilliumspecies are an industrially important group of fungi. Cyclophilins are ubiquitous proteins and several members of this family exhibit peptidyl-prolylcis-transisomerase (PPIase) activity. We had earlier demonstrated that the salt-induced PPIase activity in a halotolerant strain ofP. oxalicumwas associated with enhanced expression of a cyclophilin gene,PoxCYP18. Cloning and characterization of PoxCYP18 revealed that its cDNA consists of 522 bp encoding a protein of 173 amino acid residues, with predicted molecular mass and pI values of 18.91 kDa and 8.87, respectively. The recombinant PoxCYP18 can catalyzecis-transisomerization of peptidyl-prolyl bond with a catalytic efficiency of 1.46 × 107M-1s-1and is inhibited specifically only by cyclosporin A, with an inhibition constant of 5.04 nM. PoxCYP18 consists of two cysteine residues at positions -45 and -170, and loses its activity under oxidizing conditions. Substitution of these residues alone or together by site-directed mutagenesis revealed that the PPIase activity of PoxCYP18 is regulated through a redox mechanism involving the formation of disulfide linkages. Heterologous expression of PoxCYP18 conferred enhanced tolerance to salt stress in transgenicE. colicells, implying that this protein imparts protection to cellular processes against salt-induced damage.
Combined Transcriptome and Metabolome Analysis of Alginate Oligosaccharides Alleviating Salt Stress in the Rice Seedling Stage
Authors: Du You-Wei , Liu Ling , Feng Nai-Jie , Zheng Dian-Feng , Liu Mei-Ling , Zhou Hang , Deng Peng , Wang Ya-xing , Zhao Hui-Min 
Published: July 2023

Abstract
Background: Salt stress is one of the main limiting factors of rice production. Alginate oligosaccharides can enhance plant stress resistance. However, the molecular mechanism of the benefits of alginate oligosaccharides on rice salt tolerance remains unclear. Rice FL478 and IR29 were used to comprehensively analyze the effects of leaf spraying alginate oligosaccharides on the transcriptomes and metabolites of rice seedlings under salt stress.
Results: In this experiment, exogenous application of alginate oligosaccharides reduced the leaf membrane damage, increased the aboveground and below rice biomass, and improved rice salt tolerance. Comparative transcriptomic analyses showed that alginate oligosaccharides regulated the genes related to light-trapping proteins and RLCK receptor cytoplasmic kinases, including CBA, LHCB and Lhcp, in response to salt stress. In the metabolome profile study, among 22 and 50 different metabolites treated with alginate oligosaccharides + salt in FL478 and IR29, the abundance of metabolites with antioxidant activity, such as 6-Hydroxymelatonin, Wedelolactone and L-Histidine increased significantly. Combined transcriptome and metabolome analyses revealed that dehydroascorbic acid in the glutathione and ascorbic acid cycles plays a vital role in salt tolerance mediated by alginate oligosaccharides.
Conclusion: Alginate oligosaccharides activate multiple pathways to cope with the adverse effects of salt stress. This study provides a molecular basis for alginate oligosaccharides alleviating salt stress damage in rice.
Influence of periodic pulse intake on the ventilation efficiency of positive pressure explosion-proof robot
Authors: Fang Ming , Chu Xufeng , Yu Liang , Fang Yu , Hou Liangliang , Cheng Xu , Wang Junlong 
Published: July 2023

Abstract
When the positive pressure explosion-proof robot is in ventilation, if the air is filled into the cavity with a constant pressure, a stable flow field will be formed in the cavity. There is a stagnation zone of airflow in the corner position, which will cause the accumulation of explosive gas. In order to solve this problem, the ventilation method of periodic pulse intake is adopted on the basis of the existing robot positive pressure explosion-proof structure. The variation of explosive gases concentration in the robot cavity with time under constant pressure and pulse pressure with different periods and amplitudes is compared. According to the simulation and experimental results, it is found that the pulse intake is beneficial to the ventilation of the corner position. The period and amplitude of the pulse intake has an effect on the ventilation efficiency, when the period is the same, the greater the amplitude of the pulse intake, the higher the ventilation efficiency; when the amplitude is the same, the smaller the period of the pulse intake, the higher the ventilation efficiency.
Study the association of NAT2 590G&gt;A and UCP2 G(-866)A genetic variations with presbycusis risk
Authors: Karimnia Faezeh , Jazayeri Omid , Karimian Mohammad , Jorjani Eisa 
Published: July 2023

Abstract
Background
Presbycusis is a sensory disorder that is highly prevalent in older adults. Various genetic and non-genetic (environmental) factors are involved in the development of presbycusis. One of the main factors involved in the pathology of presbycusis is oxidative stress. NAT2 and UCP2 genes have an important function by detoxification of xenobiotics and controlling the amount of reactive oxygen species (ROS), respectively. Alterations in these genes cause the accumulation of ROS and ultimately cell damage in the inner ear, which itself can lead to hearing disorders including presbycusis.
Methods and Results
This study aimed to investigate the association of NAT2 590G > A (rs 1799930) and UCP2 G(-866)A (rs659366) with the risk of presbycusis in an Iranian population. In this case-control study, 120 healthy people and 120 patients with presbycusis were enrolled. Genotypes of mentioned polymorphisms were determined by using a PCR-RFLP protocol. According to data analysis, the AA genotype of the UCP2 gene (OR = 3.200, 95% CI = 0.1.216–8.416, p = 0.018), A allele, (OR = 1.679, 95% CI = 1.14–2.473, p = 0.008) and the dominant GA + AA/GG model (OR = 1.8421, 95% CI = 1.1009–3.0822, p = 0.02) were associated to the increased risk of presbycusis. Bioinformatics analysis of this polymorphism revealed that it changes one of the CpG islands in the promoter region and may consequently alter UCP2 gene expression.
Conclusions
There was no significant association between NAT2 590G > A polymorphism and presbycusis risk. Our findings highlight UCP2 G(-866)A polymorphism as a biomarker in the diagnosis of presbycusis disease.
Total phenol contents, total flavonoid contents, antioxidant activities of Methanol extracts of Amomum Subulatum, Lippia adoensis, Coriandram sartivum, and Ruta chalepensis sold from Jigjiga market, Ethiopia
Authors: Belew Aderaw Anteneh 
Published: July 2023

Abstract

This research work aimed to analyze the total phenolic, flavonoid contents, and antioxidant properties of four selected medicinal plantsAmomum subulatum,Lippia adoensis,Coriandrum sativum, andRuta chalepensis. The Folin-Ciocalteu method to measure total phenolic content, and the aluminum chloride colorimetric method to measure total flavonoid content, the DPPH(1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)), and FRAP radical scavenging assay was used to measure the antioxidant activity. Results showed thatLippia adoensis (50 ± 0.23 mgGAE/g) and (20.5 ± 1.2 mgQE/g)and Ruta chalepensis (45 ± 0.76 mgGAE/g) and(17.3 ± 0.9 mgQE/g)have the highest phenolic and flavonoid content. The highest radical scavenging effect was observed inLippia adoensisIC50 values 77.3 ± 2.8, 63.2 ± 2.3, and 15.8 ± 1.7 (µg/mL) DPPH, ABTS, and FRAP respectively. There is a positive correlation between total phenolic content, a flavonoid with antioxidant activity. Based on these results of the investigation, it could be concluded thatLippia adoensisis a rich source of phenolic compounds as natural antioxidants of high value.
A novel coagulation-related lncRNA predicts the prognosis and immune of clear cell renal cell carcinoma
Authors: Wu Wensong , Fan Chang , Jianghui Zhang , Shuai Tang , Zheng Lv , Chen Fangmin 
Published: July 2023

Abstract
Background Renal cell cancer is associated with the coagulation system. Long non-coding RNA (lncRNA) expression is closely associated with the development of clear cell renal cell carcinoma (ccRCC). The aim of this study was to build a novel lncRNA model to predict the prognosis and immunological state of ccRCC.Method The transcriptomic data and clinical data of ccRCC were retrieved from TCGA database, subsequently, the lasso regression and lambda spectra were used to filter prognostic lncRNAs. ROC curves and the C-index were used to confirm the predictive effectiveness of this model. We also explored the difference in immune infiltration, immune checkpoints, tumor mutation burden (TMB) and drug sensitivity between the high- and low-risk groups.Results We created an 8 lncRNA model for predicting the outcome of ccRCC. Multivariate Cox regression analysis showed that age, tumor grade, and risk score are independent prognostic factors for ccRCC patients. ROC curve and C-index revealed the model had a good performance in predicting prognosis of ccRCC. GO and KEGG analysis showed that coagulation related genes were related to immune response. In addition, high risk group had greater TMB level and higher immune checkpoints expression. Sorafenib, Imatinib, Pazopanib, and etoposide had higher half maximal inhibitory concentration (IC50) in the high risk group whereas Sunitinib and Bosutinib had lower IC50.Conclusion This novel coagulation-related long noncoding RNAs model could predict the prognosis of patients with ccRCC, and coagulation-related lncRNA may be connected to the tumor microenvironment and gene mutation of ccRCC.