bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum state preparation using tensor networks
Authors: Melnikov Ar A , Termanova A A , Dolgov S V , Neukart F , Perelshtein M R 
Published: May 2023

AbstractQuantum state preparation is a vital routine in many quantum algorithms, including solution of linear systems of equations, Monte Carlo simulations, quantum sampling, and machine learning. However, to date, there is no established framework of encoding classical data into gate-based quantum devices. In this work, we propose a method for the encoding of vectors obtained by sampling analytical functions into quantum circuits that features polynomial runtime with respect to the number of qubits and provides>99.9%accuracy, which is better than a state-of-the-art two-qubit gate fidelity. We employ hardware-efficient variational quantum circuits, which are simulated using tensor networks, and matrix product state representation of vectors. In order to tune variational gates, we utilize Riemannian optimization incorporating auto-gradient calculation. Besides, we propose a ‘cut once, measure twice’ method, which allows us to avoid barren plateaus during gates’ update, benchmarking it up to 100-qubit circuits. Remarkably, any vectors that feature low-rank structure—not limited by analytical functions—can be encoded using the presented approach. Our method can be easily implemented on modern quantum hardware, and facilitates the use of the hybrid-quantum computing architectures.
Manufacturing and metrological characterization of reference charpy specimens: first evaluations
Authors: Omena de Moura Frank , Fabrício Carlos Alberto , Moreira Marcelo Ferreira , Pires Castanho Manuel Antônio , Moro João Roberto 
Published: May 2023

Abstract
The first evaluations of the manufacture and metrological characterization of reference specimens for indirect calibration of Charpy impact testing machines by the Institute for Technological Research (IPT) are presented, seeking through the laboratory resources and expertise of the Institute, the accreditation of the laboratory as a producer of this reference material. The specimens are manufactured with 300 M steel by conventional machining. Heat treatments of normalizing, quenching, and tempering were used to control the mechanical properties. To obtain greater homogeneity in the specimens, it was decided to use tubular laboratory ovens and manufacture small batches with 32 specimens each. Initially, 2 batches were manufactured, one target at a nominal Charpy energy of 30 J and another 54 J. The pilot batches of 30 J and 54 J showed, respectively, standard deviations of 0.89 HRC and 0.96 HRC between samples and mean hardness with errors of −0.22 HRC and 0.83 HRC. The microstructures obtained after the heat treatments are tempered martensite and in the second batch, it is possible to observe that the microstructure is a little more spheroidized due to the higher tempering temperature.
Similarity matrix average for aggregating multiplex networks
Authors: Baccini Federica , Barabesi Lucio , Petrovich Eugenio 
Published: May 2023

Abstract
We introduce a methodology based on averaging similarity matrices with the aim of integrating the layers of a multiplex network into a single monoplex network. Multiplex networks are adopted for modelling a wide variety of real-world frameworks, such as multi-type relations in social, economic and biological structures. More specifically, multiplex networks are used when relations of different nature (layers) arise between a set of elements from a given population (nodes). A possible approach for analyzing multiplex similarity networks consists in aggregating the different layers in a single network (monoplex) which is a valid representation—in some sense—of all the layers. In order to obtain such an aggregated network, we propose a theoretical approach—along with its practical implementation—which stems on the concept of similarity matrix average. This methodology is finally applied to a multiplex similarity network of statistical journals, where the three considered layers express the similarity of the journals based on co-citations, common authors and common editors, respectively.
The Histopathology of Cold Agglutinin Disease–Associated B-Cell Lymphoproliferative Disease
Authors: Guenther Angela , Tierens Anne , Malecka Agnieszka , Delabie Jan 
Published: May 2023

Abstract

Objectives
Primary cold agglutinin disease is a type of autoimmune hemolytic anemia caused by circulating antibodies against I antigen, a carbohydrate expressed on most cells, including red blood cells. The underlying disease has been characterized in recent years as a distinct B-cell lymphoproliferative disease of the bone marrow, occurring mostly in the elderly. The disease has been now been included as a separate entity in the most recent classifications of mature B-cell neoplasms.

Methods
A review of the characteristics of cold agglutinin disease is provided, with an emphasis on the pathology features.

Results
A detailed description of the histopathology, immunophenotype, and genetics of cold agglutinin disease is provided and compared to other B-cell lymphoproliferative diseases in the bone marrow with similar features.

Conclusions
Recognition of the pathology features of cold agglutinin disease allows to distinguish it from other diseases, especially lymphoplasmacytic lymphoma and marginal zone lymphoma.
CW-NET for multitype cell detection and classification in bone marrow examination and mitotic figure examination
Authors: Wang Ching-Wei , Huang Sheng-Chuan , Khalil Muhammad-Adil , Hong Ding-Zhi , Meng Shwu-Ing , Lee Yu-Ching 
Published: May 2023

Abstract

Motivation
Bone marrow (BM) examination is one of the most important indicators in diagnosing hematologic disorders and is typically performed under the microscope via oil-immersion objective lens with a total 100× objective magnification. On the other hand, mitotic detection and identification is critical not only for accurate cancer diagnosis and grading but also for predicting therapy success and survival. Fully automated BM examination and mitotic figure examination from whole-slide images is highly demanded but challenging and poorly explored. First, the complexity and poor reproducibility of microscopic image examination are due to the cell type diversity, delicate intralineage discrepancy within the multitype cell maturation process, cells overlapping, lipid interference and stain variation. Second, manual annotation on whole-slide images is tedious, laborious and subject to intraobserver variability, which causes the supervised information restricted to limited, easily identifiable and scattered cells annotated by humans. Third, when the training data are sparsely labeled, many unlabeled objects of interest are wrongly defined as background, which severely confuses AI learners.

Results
This article presents an efficient and fully automatic CW-Net approach to address the three issues mentioned above and demonstrates its superior performance on both BM examination and mitotic figure examination. The experimental results demonstrate the robustness and generalizability of the proposed CW-Net on a large BM WSI dataset with 16 456 annotated cells of 19 BM cell types and a large-scale WSI dataset for mitotic figure assessment with 262 481 annotated cells of five cell types.

Availability and implementation
An online web-based system of the proposed method has been created for demonstration (see https://youtu.be/MRMR25Mls1A).
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway
Authors: Zhou Mengqi , Gao Yue , Wu Shujuan , Chen Jiao , Ding Jinli , Wang Yaqin , Yang Jing 
Published: May 2023

Abstract
Trophoblasts are significant components of the placenta and play crucial roles in maternal-fetal crosstalk. Adequate trophoblast migration and invasion are essential for embryo implantation and healthy pregnancy. Ubiquitin-specific protease 7 (USP7), a member of the deubiquitinating enzyme family, regulates the processes of migration and invasion in multiple tumor cells. However, the effects of USP7 on trophoblasts and its possible mechanism in the development of recurrent spontaneous abortion (RSA) are still unclear. In this study, we analyzed the expression of USP7 in villous tissues obtained from RSA patients and healthy controls, and then GNE-6776 (a USP7-specific inhibitor) and USP7 siRNA were used in a trophoblast cell line, HTR-8/SVneo, to further assess the effect of USP7 on the biological function of trophoblasts. Our results provide convincing evidence that USP7 is downregulated in the placental villous tissues of RSA patients. USP7 was found to have a crucial role in the proliferation, apoptosis, migration, invasion, and epithelial-mesenchymal transition (EMT) process of trophoblast cells. Further experiments revealed that USP7 directly interacted with the enhancer of zeste homolog 2 (EZH2) and regulated the Wnt/β-catenin signaling pathway in trophoblasts. Taken together, these findings indicate the vital role of USP7 in regulating trophoblast proliferation, migration and invasion, thus affecting the pathogenesis of RSA, providing new insights into the important role of USP7 in the maternal-fetal interface.
Large-scale activation likelihood estimation meta-analysis of parkinsonian disorders
Authors: Ellis Elizabeth G , Joutsa Juho , Morrison-Ham Jordan , Younger Ellen F P , Saward Jacqueline B , Caeyenberghs Karen , Corp Daniel T 
Published: May 2023

Abstract
Parkinsonism is a feature of several neurodegenerative disorders, including Parkinson’s disease, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. Neuroimaging studies have yielded insights into parkinsonian disorders; however, due to variability in results, the brain regions consistently implicated in these disorders remain to be characterized. The aim of this meta-analysis was to identify consistent brain abnormalities in individual parkinsonian disorders (Parkinson’s disease, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy) and to investigate any shared abnormalities across disorders. A total of 44 591 studies were systematically screened following searches of two databases. A series of whole-brain activation likelihood estimation meta-analyses were performed on 132 neuroimaging studies (69 Parkinson’s disease; 23 progressive supranuclear palsy; 17 corticobasal syndrome; and 23 multiple system atrophy) utilizing anatomical MRI, perfusion or metabolism PET and single-photon emission computed tomography. Meta-analyses were performed in each parkinsonian disorder within each imaging modality, as well as across all included disorders. Results in progressive supranuclear palsy and multiple system atrophy aligned with current imaging markers for diagnosis, encompassing the midbrain, and brainstem and putamen, respectively. PET imaging studies of patients with Parkinson’s disease most consistently reported abnormality of the middle temporal gyrus. No significant clusters were identified in corticobasal syndrome. When examining abnormalities shared across all four disorders, the caudate was consistently reported in MRI studies, whilst the thalamus, inferior frontal gyrus and middle temporal gyri were commonly implicated by PET. To our knowledge, this is the largest meta-analysis of neuroimaging studies in parkinsonian disorders and the first to characterize brain regions implicated across parkinsonian disorders.
How well do orthodontic RCTs comply with CONSORT guidelines?
Authors: Mobarak Dima , Harrison Jayne E , Spencer Sally 
Published: May 2023

Summary

Objectives
To assess the changes in compliance with the Consolidated Standards of Reporting Trials (CONSORT) guidelines for randomized controlled trials (RCTs) in four orthodontic journals. To assess whether reporting of randomization, concealment, and blinding has improved.

Methods
Electronic hand searching was undertaken to identify orthodontic RCTs published in four orthodontic journals from January 2016 to June 2017 (T1) and from January 2019 to June 2020 (T2). The journals were the American Journal of Orthodontics and Dentofacial Orthopaedics (AJO-DO), Angle Orthodontist (AO), European Journal of Orthodontics (EJO), and Journal of Orthodontics (JO). Each item on the CONSORT checklist was scored as either reported, not reported, or not applicable for each paper reporting an RCT.

Results
The study included 69 papers reporting an RCT published in T1 and 64 RCTs published in T2. The median CONSORT score in T1 was 48.7% (interquartile range [IQR] 27.6%, 68.6%) and 67% in T2 (IQR 43.9%, 79.5%). This increase was statistically significant (P = 0.001) and largely attributable to improved reporting in AO (P = 0.016) and EJO (P = 0.023). Reporting did not change significantly in AJO-DO (P = 0.13) or in JO (P = 1.0). Reporting of random allocation sequence generation (OR 2.09; 95% CI 1.01, 4.29) and concealment of allocation (OR 2.27%, 95% CI 1.12, 4.57) were significantly higher in T2 compared with T1. Reporting of blinding did not change significantly.

Conclusion
Overall reporting of CONSORT items in reports of orthodontic RCTs published in the AJO-DO, AO, EJO, and JO, improved significantly from 2016–17 to 2019–20. This could be improved further by authors, journal referees, and editors adhering to the guidelines.
Management of modifiable risk factors and comorbidities in atrial fibrillation: suggestions for improvement from a patient perspective
Authors: Klavebäck Sofia , Svennberg Emma , Nymark Carolin , Braunschweig Frieder , Lidin Matthias 
Published: May 2023

Abstract

Aims
In patients with atrial fibrillation (AF), improved management of modifiable risk factors and concomitant diseases is recommended by guidelines, yet many AF patients have sub-optimal risk factor management. Digital health solutions may offer support in this matter. This study aims to identify how patients with AF perceive they could be supported by a digital tool aimed to optimize management of comorbidities and modifiable risk factors associated with an unhealthy lifestyle.

Methods and results
This was a qualitative, descriptive study based on four semi-structured focus-group interviews analysed by manifest content analysis. Sixteen AF patients with recent in- or outpatient encounters were included [age 68 (52–78) years; 43% female; BMI 29.5 (20.4–35.8) kg/m2; paroxysmal/persistent AF (50%/50%); AF duration 7 (0–22) years]. Relevant comorbidities were hypertension (88%), heart failure (25%), diabetes mellitus type 2 (19%), and ischaemic heart disease (13%). The patients’ suggestions were summarized into three main categories. First, person-centred information is essential, meaning that information should be customized and conveyed in an appropriate manner and include practical tips. Second, patients desire help with managing lifestyle habits in a way that is applicable in everyday life, and patients desire help with creating habits. Third, regular communication is necessary including inspirational reminders and motivational feedback.

Conclusion
Patients with AF request person-centred information, support in managing healthy lifestyle habits, and more regular communication with caregivers. This study provides a first foundation on how to better support AF patients, and using a digital tool in standard care may improve outcomes and reduce cost of care.
Genomic insight into Algoriphagus limi sp. nov. isolated from a mudflat on the Yellow Sea coast
Authors: Ahn Soyeon , Kim Jong-Hwa , Yoon Jung-Hoon , Lee Jung-Sook , Sukhoom Ampaitip , Kim Wonyong 
Published: May 2023

Abstract
A Gram-negative, non-motile, and reddish-orange colored bacterium, designated CAU 1643T, was isolated from a mudflat collected in Ganghwa Island, Republic of Korea. The bacterium was found to grow optimally at 30°C, pH 9.0–9.5, and with 0%–1% (w/v) NaCl. The highest 16S rRNA gene sequence similarities to the bacterium were Algoriphagus kandeliae XY-J91T (97.9%), A. aquimaris F21T (97.1%), A. formosus XAY3209T (97.0%), and A. marincola DSM 16067T (96.2%). The DNA G + C content of the type strain was 40.35 mol%. The average nucleotide identity and digital DNA–DNA hybridization values between strain CAU 1643T and the reference strains were below the threshold value for species demarcation. The predominant cellular fatty acids were iso-C15:0, iso-C17:0 3-OH, and Summed Feature 9. The major respiratory quinone was menaquinone-7. The genome showed three putative biosynthetic gene clusters that are responsible for different secondary metabolites. Moreover, CAU 1643T contains 72 genes that encode carbohydrate-active enzymes. Based on phenotypic, phylogenetic, and chemotaxonomic evidence, strain CAU 1643T represents novel species in the genus Algoriphagus, for which the name A. limi sp. nov. is proposed. The type strain is CAU 1643T ( = KCTC 92080T, = MCCC 1K07150T).
Internal injuries in marine fishes caught in beam trawls using electrical versus mechanical stimulations
Authors: Boute P G , Rijnsdorp A D , van Leeuwen J L , Pieters R P M , Lankheet M J 
Published: May 2023

Abstract
To improve the ecological and economic sustainability in the Dutch beam trawl fishery, tickler chains were replaced by electrical pulse stimulation to drive common sole (Solea solea) out of the seabed. Because electrical stimulation may cause internal injuries, we quantified this risk by sampling fish species from commercial beam trawlers and recording spinal injuries and haemorrhages from X-radiographs and autopsy. To distinguish mechanically-induced and electrical-pulse-induced injuries, we compared injuries in ten species sampled from pulse (PUL) and tickler-chain (TCK) trawlers and four species sampled from PUL trawlers with the stimulus switched on or off. Co-occurrence of a major spinal injury and major haemorrhage at the same location was only observed in PUL samples, and were frequently (40%) observed in Atlantic cod (Gadus morhua) and in low numbers (0–2%) in whiting (Merlangius merlangus), grey gurnard (Eutrigla gurnardus), and greater sandeel (Hyperoplus lanceolatus), but not in flatfishes and other species. In cod, injury occurrence correlated with fish length, with lower probabilities for small fish. Major spinal injury or major haemorrhage occurrence in PUL (range: &lt;1–16%) was lower than in TCK (range: &lt;1–42%) in eight of the ten species studied. Population level consequences of pulse-induced injuries are considered negligible.
Winning Hearts and Minds: Soft Power, Cinema, and Public Perceptions of the United States and China in Brazil
Authors: Guan Miaofang , Chagas-Bastos Fabrício H , Nishijima Marislei 
Published: May 2023

Abstract
In this article, we explore the relationship between soft power projection and public opinion, specifically investigating how cinema as a soft power resource can shape people's positive perceptions about a country. While soft power has been defined as a form of persuasive power associated with intangible resources such as culture, ideology, and institutions, the link between these resources and public opinion has received limited attention in previous research. This study aims to fill this gap by using the film industry as a proxy for soft power projection. We compare the United States’ and China's soft power sources and projections through an online survey with 908 participants in Brazil. Our findings indicate that exposure to soft power via films can shape people's positive perceptions of countries. However, some dimensions of soft power appear to be more challenging to activate than others, such as patriotic films’ association with admiration for US military power. The study also discovered that soft power activation may be context dependent, with greater knowledge of a country's soft power resources in a particular context leading to increased soft power projection/activation. We contribute to research by empirically expanding our understanding of soft power dynamics and how power resources can be converted into public opinion in world politics.
Forum: Challenges to Scholarship and Policy During Crises
Authors: Davies Graeme , De Alba-Ulloa Jessica , Ghosn Faten , Gleditsch Kristian Skrede , Kneuer Marianne , Milner Helen , Solingen Etel 
Published: May 2023

Abstract
The COVID-19 pandemic has had a dramatic influence on mortality and public health and generated much speculation on potential impacts on international politics. Fast-moving crises such as the COVID pandemic and 2008 financial crises entail many challenges for scholarship; events evolve rapidly, our prior knowledge base is limited, it is unclear whether existing theories or analogies apply, and new research findings emerge quickly but also erratically. Researchers face demands to engage with policy and general audiences when normal standards of scholarship may be difficult to apply. Crises can also have a dramatic impact on how we conduct research and interact with other scholars. The forum introduction outlines how crises pose challenges for scholarship and policy and the value of approaching crises such as COVID-19 in comparative perspective. Milner highlights the important differences between the immediately observable short-term impact of crises and the more difficult to evaluate long-run impacts. Kneuer examines how crises can impact political change, detailing how COVID countermeasures can serve as a pretext for autocratization and the safeguards afforded by institutions. Solingen examines the impact of serial crises on global value chains and the difficulties in tracing impacts when crises are compounded. De Alba-Ulloa documents how scholars in the Global South and North face similar challenges during the COVID pandemic, but differences in resources to mitigate can exacerbate inequalities. Davies highlights the difficulties in studying public opinion during COVID and need for behavioral data to understand global health emergencies. Ghosn examines dilemmas in interacting with severely affected communities during crises and offers advice on better practices.
Pressure in the Operating Room: A Potential Contributor to Hospital-Acquired Pressure Injuries
Authors: Milazzo Thomas , Loo Hannah , Rogers Alan , Cartotto Robert 
Published: May 2023

Abstract
Burn patients are at risk for hospital-acquired pressure injuries (HAPIs). An unexamined factor that may contribute to HAPI development is the effect of pressure from the operating table during surgery. The purpose of this study was to measure pressure on the buttocks and sacral area during burn surgery under general anesthesia (GA). Prospective study of consecutive adult burn patients admitted to an ABA-verified burn center who required surgery under GA between January 06, 2022 and December 08, 2022. We studied only cases that were supine, including those with both legs down (LD), one leg suspended (1LU), or both legs suspended (2LU). Interface pressures on the buttocks and sacral area were measured using a commercial sensor mat. Thousands of individual pressure measurements were integrated to show average and peak pressures over repetitive 10-minute intervals during the entire operation. Recordings were completed in 41 procedures among 28 patients (48.3 ± 16.9 years, % TBSA burn 19.2 ± 17.1, weight 80.2 ± 19.7 kg, BMI 26.7 ± 6.2). Both average pressure (Pave) and peak pressure (Ppeak) increased significantly with greater number of elevated legs (p &lt; .001). During 2LU periods, Ppeak exceeded 100 mmHg for almost half the operative duration. Pave crept steadily upwards over time and had a positive relationship with weight, regardless of leg elevation. Prolonged moderate to high pressures are exerted on the sacral and buttock areas, especially with one or both legs suspended, during burn surgery. These novel observations suggest that pressure from the operating table could contribute to HAPI development.