bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mendelian Randomization Study Reveals Causal Pathways for Hypertrophic Cardiomyopathy, Cardiovascular Proteins, and Atrial Fibrillation
Authors: Zhang Yifei , Guo Chenyuan , Wang Lanxin , Wu Lei , Lv Jia , Huang Xia , Yang Wuxiao 
Published: January 2025

Aims/Background Research evidence has demonstrated a significant association between hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF), but the causality and pattern of this link remain unexplored. Therefore, this study investigated the causal relationship between HCM and AF using a two-sample and bidirectional Mendelian randomization (MR) approach. Additionally, this assessed the role of cardiovascular proteins (CPs) associated with cardiovascular diseases between HCM and AF by applying a two-step MR analysis. Methods Data for HCM, AF, and 90 CPs were obtained from the Finn Gen and IEU Open GWAS Project databases. MR-Egger, inverse variance weighting (IVW), weighted median estimator (WME), weighted mode, and simple mode were used to estimate causal inferences. Furthermore, Cochran’s Q test, MR-Egger’s intercept terms, and Leave-one-out methods determined the heterogeneity, horizontal pleiotropy, and sensitivity. Additionally, mediation effects were used to assess the role of CPs in the relationship between HCM and AF. Results Two-sample and bidirectional MR analysis revealed HCM as a risk factor for AF (odds ratio (OR) = 1.008, 95% confidence interval (CI): 1.001–1.016, p = 0.029) and AF was found to increase the risk of developing HCM (OR = 1.145, 95% CI: 0.963–1.361, p = 0.126). Moreover, Two-step MR analyses indicated that 5 CPs were causally associated with HCM; 12 CPs with AF and 1 CP (Melusin) with both HCM and AF. Additionally, Melusin was observed as a protective factor for both HCM and AF and may serve as a mediator variable for these two conditions (mediation effect 0.0004, mediation ratio 5.5178%, 95% CI: 5.4624–5.5731). Conclusion HCM may increase the risk of developing AF, with Melusin serving as a mediator for this risk.
Faraday rotation of the He+-ion-implanted and diamond-blade-diced magneto-optical glass ridge waveguide
Authors: Liu Chun-Xiao , Xing Shu-dong , Wang Zi-Hao , Li Ke-Yao , Sun Wang , Zhou Yu-Cheng 
Published: January 2025

In this work, we report on the fabrication and Faraday rotating properties of the ridge waveguide in magneto-optical glass. The planar and ridge waveguides are formed using 0.4MeVHe+-ion implantation with a fluence of 6×1016ion/cm2 and 2.0×104rpm diamond blade dicing with a speed of 0.2 mm/s. The refractive index distribution and dark-mode spectrum are obtained by the RCM and prism-coupling system, respectively. Zeiss and Nikon microscopes are used to capture the micro-images of the planar and ridge waveguides, respectively. After annealing at 260°C for 1 h, the near-field light intensity distributions of the planar and ridge waveguides are measured by the end-face coupling method. Faraday rotation of the bulk and ridge waveguides is measured and analyzed based on the magneto-optical effect measurement system. Although there is a slight reduction in the Verdet constant of the waveguide compared with that of pure magneto-optical glass, the Faraday effect is well preserved in the ridge structure. It has potential for applications in magneto-optical waveguides as integrated optical rotators and isolators.
Inverse-designed broadband meta-coupler with high efficiency on thin-film lithium niobate
Authors: Wei Zhiwei , Wu Jiangwei , Chen Chengyu , Wan Wenjie , Chen Yuping , Chen Xianfeng 
Published: January 2025

Efficiently coupling free-space light with a large bandwidth to arbitrary positions in on-chip systems is a significant challenge. In this work, we address this issue by utilizing an inverse-designed metasurface as a meta-coupler, replacing conventional grating couplers. Our meta-coupler achieved a maximum coupling efficiency of 90% (). The 1-dB bandwidth spans 138 nm (1450–1588 nm), while the 3-dB bandwidth extends over 300 nm (1425–1725 nm), far exceeding the bandwidth of traditional grating couplers used on thin-film lithium niobate. This meta-coupler demonstrates strong potential for on-chip systems requiring multi-wavelength interactions, such as integrated lasers and amplifiers.
Auf dem Weg zum datengetriebenen Unternehmen: Handlungsempfehlungen für ein effektives Datenmanagement in Enterprise Systems auf Basis von Data3M
Authors: Löwe Seline , Freese Isabella , Kunath Caroline , Schäffer Thomas , Beckmann Helmut 
Published: January 2025

Zusammenfassung
Ein effektives Datenmanagement ist entscheidend für den Erfolg von Unternehmen in der digitalen Transformation. Diese stehen vor der Herausforderung, ihre Datenmanagement-Initiativen systematisch zu bewerten und zu optimieren. Dieser Beitrag liefert Handlungsempfehlungen für das Datenmanagement in Enterprise Systems, basierend auf einem eigens entwickelten Reifegradmodell für datengetriebene Unternehmen, dem Data3M. Das Modell integriert Erkenntnisse aus bestehenden Modellen, Anforderungen aus der Literatur sowie Expertenmeinungen, um eine fundierte Grundlage für die Ableitung praxisorientierter Handlungsempfehlungen zu schaffen. Das Data3M ermöglicht eine umfassende Bewertung des Datenmanagements auf fünf Reifegradstufen und adressiert dabei die Schlüsselaspekte in den Dimensionen Strategie, Organisation, Daten und Systeme. Es hilft Unternehmen, die notwendigen Voraussetzungen für IT-Systeme zur Unterstützung datengetriebener Entscheidungsfindung zu ermitteln und zu implementieren.
Tenascin-X Deficiency Causing Classical-Like Ehlers-Danlos Syndrome Type 1 in Humans is a Significant Risk Factor of Gastrointestinal and Tracheal Ruptures
Authors: van Gurp Jonneke E. , Lechner Rosan L. , Micha Dimitra , Maugeri Alessandra , Dulfer Eelco , van Dijk Fleur S. , Keszthelyi Daniel , Malfatti Edoardo , Kubo Akiharu , Voermans Nicol C. , Demirdas Serwet 
Published: January 2025

INTRODUCTION:
Classical-like Ehlers-Danlos syndrome type 1 (clEDS1) is a very rare form of Ehlers-Danlos syndrome caused by tenascin-X deficiency, with only 56 individuals reported in medical literature. Tenascin-X is an extracellular matrix protein needed for collagen stability. Previous publications propose that individuals with clEDS1 might be at risk of gastrointestinal (GI) tract perforations and/or tracheal ruptures. The aim of this study was to characterize complications resulting from perforations of the GI tract and/or tracheal rupture in an international case series of individuals with clEDS1 due to disease-related tissue fragility.

METHODS:
This case series includes individuals with confirmed clEDS1 and GI perforations and/or tracheal ruptures from participating centers. Researchers who previously reported such individuals were contacted for additional information. A retrospective assessment of clinical features was performed.

RESULTS:
Fifteen individuals were included. Ten had spontaneous GI perforations, 7 of whom had multiple GI perforations. Almost all had severe diverticulosis. Three individuals experienced iatrogenic tracheal ruptures.

DISCUSSION:
Severe GI complications, such as perforation, and tracheal rupture were observed in a substantial number of individuals with clEDS1. As these features seem significantly more common in clEDS1 than in the average population, we advise vigilance during intubation and GI endoscopic interventions of individuals with clEDS1. Routine referrals to clinical geneticists are recommended for patients with symptoms indicative of clEDS1, especially with unexplained GI perforations and connective tissue symptoms. Our findings offer valuable insights for the clinical management of clEDS1 and underscore the importance of specialized care, providing a foundation for improved clinical guidelines and preventive strategies.
Wissenstransfer umgekehrt
Authors: Neumer Werner 
Published: January 2025

Zusammenfassung
Beim Reverse Mentoring lernen erfahrene Führungskräfte von jüngeren Nachwuchskräften. Es ist eine wichtige Maßnahme zur Begleitung des demografischen und digitalen Wandels und bietet den Teilnehmenden die Gelegenheit, die Gedankenwelt der anderen Generation besser zu verstehen. Der stattfindende Wissenstransfer unterstützt die digitale Transformation und fachbereichs- und hierarchieübergreifendes Netzwerken sorgt für eine offene, attraktive Unternehmenskultur. Dieser Beitrag beschreibt, wie das Konzept in der Deutschen Bundesbank gelebt wird.
Von der Theorie in die Praxis: Wie Wissensgraphen und Sprachmodelle schon heute helfen, die wissenschaftlichen Fragen von morgen zu beantworten
Authors: Karras Oliver 
Published: January 2025

Zusammenfassung
Während die digitale Transformation in vielen Lebensbereichen bereits weit fortgeschritten ist, hat die Wissenschaft das volle Potenzial der Digitalisierung bisher nicht ausgeschöpft. Es besteht ein dringender Bedarf, diese voranzutreiben. Für diesen Zweck ist es erforderlich, über die traditionelle, dokumentenbasierte Darstellung von Daten und Wissen hinauszugehen, um sowohl dem Menschen als auch der Maschine die effiziente Nutzung dieser Informationen zur Beantwortung wissenschaftlicher Fragen zu ermöglichen. In diesem Kontext sind Wissensgraphen und Sprachmodelle vielversprechende Technologien. Der vorliegende Artikel betrachtet theoretisch und anhand von Praxisbeispielen, wie Wissensgraphen und Sprachmodelle jeweils einzeln als auch kombiniert zur Beantwortung wissenschaftlicher Fragen beitragen. Wissensgraphen bieten eine strukturierte und vernetzte Darstellung von Daten und Wissen, die eine Kontextualisierung und umfassende Analyse der Informationen ermöglichen. Sprachmodelle hingegen erleichtern die Interaktion mit großen allgemeinen Wissensbeständen durch natürliche Sprache. Der größte Mehrwert bei der Beantwortung wissenschaftlicher Fragen lässt sich aber durch die Kombination beider Technologien erreichen. Die Synergien, die durch die Kombination von Wissensgraphen und Sprachmodellen entstehen, vereinen die Stärken beider Ansätze und ermöglichen eine präzisere und umfassende Beantwortung wissenschaftlicher Fragen. Zukünftige Forschung muss sich darauf konzentrieren, diese Kombination weiter zu optimieren und neue Anwendungsmöglichkeiten zu erschließen, um das volle Potenzial beider Technologien auszuschöpfen.
Reforming the Indonesian Bureaucracy through State Civil Apparatus Reform, Could It be Optimized with Technology?
Authors: Amancik Amancik , Barus Sonia Ivana , Saifulloh Putra Perdana Ahmad , Nggilu Novendri M. , Nur Asrul Ibrahim 
Published: January 2025

Bureaucracy, from a societal perspective, is often perceived as complex, slow, and inefficient. Despite these criticisms, bureaucracy remains a fundamental component of governance and plays a crucial role in societal functioning. As such, bureaucratic reform has been a prominent focus of policy discussions for several decades. A technology-driven government system, coupled with a bottom-up approach, has the potential to enhance efficiency, transparency, and accountability in public administration. However, in practice, such reforms have been largely confined to central government institutions and select agencies. This study aims to explore the integration of technology within the bureaucratic system in Indonesia, with a focus on its comprehensive implementation across government structures. Employing a normative research methodology, the study emphasizes the need for the government to take proactive steps in developing a skilled workforce in information technology. The authors also recommend strategically mapping positions that can integrate technological expertise throughout government departments. Furthermore, the study proposes a comprehensive examination of the potential for replacing executive positions with artificial intelligence (AI) to streamline and simplify bureaucratic processes. In addition to technological advancements, bureaucratic reform must be accompanied by legal reform, particularly in the areas of data security and the protection of personal information. This includes redefining bureaucratic and personal data categories to ensure robust safeguards. The Personal Data Protection Law should play a pivotal role in integrating these data types and ensuring their protection. Moreover, the Telecommunications Act and the Personal Data Protection Act should foster collaboration between the government and technology companies to develop effective security solutions. Lastly, strengthening the Ombudsman as a public service oversight institution is essential to ensuring transparency and accountability in the implementation of bureaucratic and technological reforms.
Differential Object Marking in DGS (German Sign Language): A prominence-based account of the use of PAM based on naturalistic data
Authors: de Souza Santos Thiago , Dietrich Antonia , Steinbach Peggy , Perniss Pamela 
Published: January 2025

This paper examines the nature of object marking in DGS (German Sign Language), providing an account of the behavior of the sign glossed as PAM, previously analyzed as an agreement auxiliary (person agreement marker) and more recently as a differential object marker (Bross 2020). We investigate the influence of animacy and definiteness (object individuation) and the affectedness of the object as properties that have been claimed to be relevant for differential object marking, in general, and for DGS, in particular. We provide an account of object-marking based on the notion of linguistic prominence, specifically on how the use of PAM in DGS may be interpreted as providing additional information (marking) that brings the object into the center of attention. We suggest that the use of PAM is triggered through object prominence in three ways: being highly individuated (animate, definite); being a stimulus/causer rather than a patient; not being (very) affected by the verbal action. In addition, we find that an association with negative intent by the subject as well as the selectional constraints on verbs occurring with PAM are captured very well for DGS by the account proposed by Meir (2003) for ISL (Israeli Sign Language), a sign language historically related to DGS.
"NOT WHO BUT <em>WHAT</em>: WHAT IS SHE?" Disembodied Quests for Utopia and Retrotopia from Mkrtich Armen’s <em>Yerevan </em>(1931) to Thomas Pynchon’s <em>V.</em> (1963)
Authors: Leupold David 
Published: January 2025

The paper engages two works of the 20th century in a cross-temporal dialogue: the novel Yerevan (1931) written 14 years after the October Revolution by the Soviet-Armenian writer Mkrtich Armen and the novel V. (1963), written three decade and one world war later by the US-American writer Thomas Pynchon. At first glance, the two works do not make for a likely pair – on the one hand, a milestone in modern North American literary history and, on the other hand, a work from the former Soviet South, written in Armenian, banned upon publication and almost forgotten until its post-Soviet republication in 2016. The essay reads the novels for the themes of utopia, retrotopia and modernities in contest. In spite of their apparent difference in context and history of origin, it demonstrates that the plots of both Armen's and Pynchon's novel are structured around bafflingly similar disembodied quests that haunt their respective main protagonists. Set in light of the Cold War and the anti-colonial struggle, Pynchon's V. stands as a placeholder for a form of Western modernity that brought humanity to the brink of self-extinction. Armen's Yerevan, on the other hand, refers to a distinctly different, revolutionary horizon of expectation characteristic for the 1920s and early 1930s, when hopes for emancipating, socialist form of modernity were not yet obscured by the dread of Stalinism. Read together (and against each other), the paper argues that the tragic-utopian quest for Asmar in the Soviet-Armenian 1930s and the ironic-(anti-)anti-utopian quest for V. in the US-American 1960s construe a complex dialectical image of human progress, its inherent possibilities and pitfalls.
The nutritional status and problems among older adults in a selected rural community of kerala
Authors: John Bindu , George Jincymol , Jose Pinky , Joseph Anu , Manoj Alina Mary , Jomon Alja Mary , Sony Chris Maria 
Published: January 2025

Older adults are vulnerable to nutritional risk states due to low food intake and presence of chronic medical conditions. Thus, they require an extended nutrition assessment.: This study aimed to assess the nutritional status and identify the common nutritional problems present among older adults in the community. A quantitative approach was used with a convenience sampling method. The participants were 50 adults, both males and females, aged above 50 years and residing in a selected catchment area of the community in Kottayam district. Data collection was extracted from a larger survey carried out in this area which used a structured questionnaire. A majority of the participants were aged between 50- 55 years (n =28, 56%), males (n = 26, 52%), belonged to nuclear families (n= 33, 66%), had high school education (n= 17, 34%), were unemployed (n =18, 36%), and married (n=48, 96%). Regarding the nutritional status, nearly 24% of the participants were overweight (n 12) and 6% were obese (n = 3). Regarding the nutritional risk factors, a majority of them were following unhealthy diets (n=39, 78%), had irregular food habits (n=32, 64%), and had the habit of skipping meals (n=31, 62%). Consumption of sugar-rich foods (n = 11, 22%), with a low intake of milk and milk products (n =36, 72%), and an intake of fried foods (n =32, 64%) were reported by the participants. Moreover, 18% of them (n =9) had regular consumption of alcohol. Nutritional risk states were present in nearly 50% of them.The study results demonstrated the presence of various lifestyle-related nutritional risk factors and gave insight into the existing nutritional patterns among older adults and the problems associated with nutritional intake.The study results highlight the need for adopting a healthy lifestyle and the dietary and behavioral modifications required as an urgent measure to tackle the problems associated with chronic disease escalating at the fastest pace in Kerala. Further studies are required to assess the specific nutritional problems in a large sample of the population and long-term monitoring of the nutritional factors.
Wyzwalać wyobraźnię z grodzeń. Polityka literatury i potencjalność
Authors: Pfeifer Kasper 
Published: January 2025

Artykuł koncentruje się na kwestii polityczności literatury (szerzej: estetyki), rozwijając pojęcia wyzwalania i grodzenia wyobraźni. W zaproponowanym ujęciu praktyka estetyczna może służyć „wyobrażaniu” nowych potencjalności życia zbiorowego. Może również wyznaczać granice temu, co być może, strukturyzując status quo i domykając „dominujące” sensoria, czyli sposoby myślenia, odczuwania oraz bycia-w-świecie, przedstawiając je jako obiektywne i nieuchronne. Pozwala to zdefiniować rewolucyjną estetykę jako pracę na rzecz otwarcia horyzontu prospektywnego i konceptualizowania tego, co dotychczas wydawało się nie do pomyślenia.
Religious Education in Indonesia
Authors: Fitriani Mohamad Iwan , Nazar Naamy  
Published: January 2025

This study focuses on how religious education contributes to build tolerance behavior and prevent or minimize ideological contestation. Therefore, this study answers a research question, namely; What are the relevant models of religious education to promote religious tolerance?. Using a qualitative approach, data were collected through documentation and interviews with informants from several selected schools and madrasas in West Lombok-West Nusa Tenggara. Data collection was also strengthened with Focus Group Discussion. Then, the data analysis used was a thematic analysis. The study found that; The relevant model of religious education to build ideal tolerance is a model of religious education characterized by components (goals, teachers, content and methods) support inclusive values and behaviors. Without inclusivism in each of these components, religious education will lead to ideological contestation, a contest of truth based on the ideology believed by each adherent of a certain belief or religion.
Curative Properties of Kencur (Kaempferia galanga L.) Extract on Mice (Mus musculus) Kidney Histopathology Exposed to Cigarette Smoke
Authors: Arianto Intan Diah Safitri , Lastoaji Firman , Sudjarwo Sri Agus , Valentinus Thomas Widiyatno , Hestiana Eka Pramyrtha , Hamid Iwan Sahrial , Herupradoto Eduardus Bimo Aksono , Lovela Aprinda Ratna 
Published: January 2025

The aim of this research was to investigate the therapeutic effects of Kencur (Kaempferia galanga L.) extract on kidney histopathological damage in male mice exposed to cigarette smoke. Twenty 8-week-old male mice were randomly divided into five treatment groups (n=5). The negative control group (C-) consisted of mice not given kencur extract or exposed to cigarette smoke, while the positive control group (C+) comprised mice exposed to cigarette smoke without kencur extract. Treatment groups included Treatment 1 (T1) administered 150 mg/kg BW of kencur extract, Treatment 2 (T2) administered 300 mg/kg BW, and Treatment 3 (T3) administered 600 mg/kg BW. Mice were exposed to cigarette smoke for 14 days. The data were analyzed using the Kruskal-Wallis test to evaluate overall differences among the treatment groups. Where significant differences were found (p<0.05), further pairwise comparisons were conducted using the Mann-Whitney test, confirming statistically significant differences between specific treatment groups. Treatment 3 (T3) was found to be the most effective in reducing histopathological damage in the kidneys of male mice. This study demonstrates that kencur extract effectively reduces histopathological damage in the kidneys of mice exposed to cigarette smoke, highlighting its potential as a protective agent against smoke-induced tissue injury.
The Simultaneous Removal of Chlorides and Calcium from Synthetic Solution and EAF Dust Washing Wastewater: The Study of the Suitability and Sustainability of Various Adsorbents
Authors: Horváthová Hedviga , Miškufová Andrea , Takáčová Zita , Bernardes Andréa Moura , Bureš Radovan , Fáberová Mária , Oráč Dušan 
Published: January 2025

This work is focused on the investigation of sorption efficiencies and capacities of different adsorbents (synthesized Hydrotalcite, natural zeolite Clinoptilolite, synthetic zeolite and waste sludge from Al anodic oxidation) for simultaneous Cl- and Ca2+ removal from a synthetic solution (CaCl2) as well as from real wastewater (from EAFD recycling) for sustainable industrial wastewater purification process. The initial samples of adsorbents, as well as after the calcination and sorption process, were characterized, and it was described their chemical and phase composition (by AAS and XRD), surface area (BET analysis), porosity (BJH method) and molecule structure (FTIR). The highest efficiency (~100%) for Ca2+ removal from the synthetic solution as well as from real wastewater showed the synthetic zeolite. However, calcined Hydrotalcite at 500°C (HT-b) appeared to be the most efficient adsorbent for the simultaneous removal of Cl- and Ca2+. In this case, the maximum sorption capacity for Cl- (50.3 mg/g) and Ca2+ (42.2 mg/g) from EAFD wastewater were obtained after 360 minutes and the highest sorption efficiencies were achieved 98.9% for Ca2+ and 81% for Cl- after 24 hours. At the same time, 82% of Pb, 91% of Cr and 40 % of SO42 were removed from wastewater by HT-b.