bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethical dimensions in encounters with families with a disabled child
Authors: Daelman Silke , De Schauwer Elisabeth 
Published: August 2023

AbstractParents of a disabled child experience complex situations with varied and sometimes contradictory needs, interests, and emotions, and with ambiguities related to the possibilities for both child and family in the context of contemporary normative ableist thinking. In this review, we propose ethics based on ‘flourishing’ and ‘thisness’; with the goal to encourage people to see encounters with parents and families as emergent experimental spaces in which we remain open and interested in developments rather than in fixed ideas. Working with parents with lived experiences of raising a disabled child, we explore the collaboration processes among families, their support networks, and (medical) professionals. These encounters require an ethical perspective, with emergent listening as central to the process. A story is used to highlight the importance of listening as part of an assemblage, recognizing what is already there and affirming the potential for change. Engaging in ethical encounters with families with a disabled child asks for epistemic humility and the willingness to be unsure. Rather than offering step‐by‐step strategies, we open up for the encounter with the ‘incalculable other’.
“Which side are you on?” A historical study of union membership composition in seven Western countries
Authors: Batut Cyprien , Lojkine Ulysse , Santini Paolo 
Published: August 2023

AbstractThis study uses surveys from the past 60 years to study union membership in Denmark, France, West Germany, Italy, Sweden, the United Kingdom, and the United States. We first revisit aggregate union densities finding that, for France and Italy, they were at times under‐ and overestimated, respectively. Second, we document the evolution of the composition of union membership in terms of gender, occupation, education, and sector. Different stylized facts emerge for different groups of countries. These facts do not lend support to the composition‐based theory that attributes deunionization to deindustrialization, nor to the technological theory that predicts the exit of the high‐skilled from unions.
Analysis of MUC6 polymorphisms on the clinicopathologic characteristics of Asian patients with oral squamous cell carcinoma
Authors: Hua Chun‐Hung , Chuang Chun‐Yi , Chien Yi‐Chung , Su Chun‐Wen , Chen Shuo‐Chueh , Liu Liang‐Chih , Yang Shun‐Fa , Yu Yung‐Luen 
Published: August 2023

AbstractHead and neck squamous cell carcinomas (HNSCCs) are generally associated with tobacco consumption, alcohol abuse or both. Mucins (MUCs) are high‐molecular‐weight glycoproteins produced by many epithelial tissues. Many studies have indicated that MUCs play an important role in cancer metastasis. MUC6 expression has been observed in gastric and oncocytic phenotypes and plays an important role during cancer progression. We found that levels of MUC6 are lower in Asian HNCC patients and affect the disease‐free survival of HNCC patients. Next, we investigated the combined effect of MUC6 polymorphisms and exposure to environmental carcinogens on the susceptibility to and clinicopathological characteristics of HNCC. Three single‐nucleotide polymorphisms (SNPs) of MUC6 (rs7481521, rs6597947 and rs61869016) were analysed using real‐time PCR. After adjusting for other co‐variants, we found that carrying a CC genotype at MUC6 rs6597947 led to a lower risk of developing oral squamous cell carcinoma (OSCC) than wild‐type carriers among non‐betel‐quid chewers. Moreover, male oral cancer patients who carried the AA + CC genotype at MUC6 rs6597947 had a lower risk of lymph node metastasis than other genotypes, suggesting a significant functional compromise and decompensated disease. Therefore, our findings suggest that genetic variations in MUC6 may correlate to OSCC and indicate the progression in OSCC patients.
The effect of Banxia‐houpo decoction on CUMS‐induced depression by promoting M2 microglia polarization via TrkA/Akt signalling
Authors: Liu Li , Zhang Rong , Chen Chang , Xia Changbo , Yao Guangda , He Xiaogang , Xia Baomei 
Published: August 2023

AbstractIt has been reported that Banxia‐houpo decoction (BXHPD) serves as the anti‐depressant treatment for a mild and severe depressive disease with limited side effects. The present study was performed to evaluate the protective effect of BXHPD on chronic unpredicted mild stress (CUMS)‐induced depression and explore its effect on TrkA/Akt‐mediated microglia polarization. The CUMS procedure was carried out, and the mice were intragastrically treated with BXHPD once daily. The selective TrkA inhibitor GW441756 was applied to further investigate the role of TrkA in BXHPD‐mediated microglia polarization. The behaviour test including open field test (OFT), sucrose preference test (SPT), novelty‐suppressed feeding test (NSFT), tail suspension test (TST) and forced swim test (FST) was performed. The concentrations of pro‐inflammatory cytokines IL‐6, TNF‐α, IL‐1β, IL‐12 and anti‐inflammatory cytokines IL‐4, IL‐10 were determined using Enzyme‐linked immunosorbent assay. The population of Iba1+ cells and the length of microglia processes were observed under the fluorescence microscope. The mRNA expressions of Arg1, Ym1 and Fizzl1 were measured by PCR. The protein expressions of TrkA, p‐Tyr490‐TrkA, p‐Ser473‐Akt, p‐Ser473‐Akt1, p‐Ser474‐Akt2, p‐CREB and Jmjd3 were detected by western blot. Our results showed that BXHPD attenuated CUMS‐induced depressive‐like behaviour, promoted anti‐inflammatory cytokines, inhibited pro‐inflammatory cytokines, suppressed microglia activation, promoted M2 phenotype‐specific indices and upregulated the expressions of TrkA, p‐Tyr490‐TrkA, p‐Ser473‐Akt, p‐Ser473‐Akt1, p‐Ser474‐Akt2, p‐CREB and Jmjd3. The above beneficial effect of BXHPD can be blocked by TrkA inhibitor GW441756. This work demonstrated that BXHPD exerted an anti‐depressant effect by promoting M2 phenotype microglia polarization via TrkA/Akt pathway.
Theorie und Praxis der Pantomime zwischen Frankreich und Österreich/Deutschland: Aspekte eines Kulturtransfers
Authors: Mazellier‐Lajarrige Catherine 
Published: August 2023

ZusammenfassungDer Beitrag untersucht Formen und Wege des Kulturtransfers zwischen Frankreich und Österreich, bzw. Deutschland, im Bereich der Pantomime, insbesondere unter dem Blickwinkel der „Texttheatralität“ (Poschmann). Bei vielen deutschsprachigen Pantomimenautoren ist die Begegnung mit der Pariser Pantomime, die 1888 mit der Gründung des „Cercle Funambulesque“ ihre Wiedergeburt feiert, für Theorie und Praxis ausschlaggebend. Diese künstlerische Befruchtung wird sowohl in den theoretischen Ansätzen als auch in den praktischen Umsetzungen präzisiert, wobei anhand eines Beispiels, nämlich LevetzowsDie beiden Pierrots, die „Theatralität“ der pantomimischen Texte im Hinblick auf ihre Nähe zum Epischen, ihr performatives Potenzial, ihre Materialität und Metatextualität analysiert wird.
A new solution to the problem of luck
Authors: Whittle Ann 
Published: August 2023

AbstractThe issue of whether and how we have the control necessary for freedom and moral responsibility is central to all control accounts of freedom and moral responsibility. The problem of luck for libertarians aims to show that indeterministic agents are ill‐equipped with the control required for freedom and moral responsibility. In view of this, we must either endorse scepticism about the possibility of free and morally responsible agents, or make some form of, possibly revisionary, compatibilism work.In this paper, I shall offer a new solution to the problem of luck for libertarians. After outlining the problem of luck, I shall argue that, given a particular approach to mental causation, indeterminism can be viewed as an essential requirement of free and morally responsible action. After this, I shall distinguish between different types of inability and show how this provides us with a solution to the problem of luck. Finally, I shall consider some advantages and objections to the proposed solution.
Incidence and risk factors of cognitive dysfunction in hemodialysis patients: A systematic review and meta‐analysis
Authors: Liu Jun , Chen Kehong , Chen Jia , Fu Lili , Zhang Weiwei , Lin Jing , Wan Jingfang 
Published: August 2023

AbstractBackgroundThe study aims to explore the incidence and risk factors of cognitive dysfunction in hemodialysis patients.MethodsPubMed, Embase, Cochrane Library, and Web of Science databases were searched for clinical studies on the association between hemodialysis and cognitive dysfunction from the database's inception to 1 December 2022. Two researchers independently completed data extraction and risk of bias assessments for the included studies. All statistical analyses were performed using STATA15.0 software.ResultsTen studies were included in this meta‐analysis, with a total of 5535 hemodialysis patients, that is, 2033 patients with cognitive dysfunction and 3502 patients with normal cognitive function. The Newcastle–Ottawa Scale scores of the included studies were greater than 5. Meta‐analysis results suggested that the incidence of cognitive dysfunction in hemodialysis patients was (effect size = 51%, 95% confidence interval [CI] [0.33, 0.69]), and hemodialysis patients with cognitive dysfunction were often older than those with normal cognition (standard mean difference [SMD] = 0.49, 95% CI [0.31, 0.68]). Female gender was a risk factor for cognitive dysfunction in hemodialysis patients (relative risk [RR] = 1.21, 95% CI [1.04, 1.41]); diabetes (RR = 1.33, 95% CI [1.04, 1.71]) and stroke (RR = 1.66, 95% CI [1.08, 2.55]) increased the incidence of cognitive dysfunction in hemodialysis patients.ConclusionsThe most important risk factors for cognitive dysfunction associated with hemodialysis might be female gender, old age, diabetes, and stroke. Close attention should be paid to such patients for early prevention.
Iridial melanocytoma in a ferruginous hawk (Buteo regalis): A case report and review of avian melanocytic neoplasia
Authors: Spitznagel Katya , Sadar Miranda J. , Terhaar Hannah , Brandao Joao , Teixeira Leandro , de Linde Henriksen Michala 
Published: August 2023

AbstractA 21‐year‐old, suspected female captive ferruginous hawk (Buteo regalis) was followed for 3 years due to an iridial mass of the left eye (OS) that progressively increased in size. Enucleation of OS was eventually recommended due to the iridial mass taking up approximately 75% of the anterior chamber, and the bird seemed less active. A complete physical examination, complete blood cell count, biochemistry, and survey radiographs were performed pre‐surgery with no findings indicating metastasis. A subconjunctival enucleation was performed and the globe was submitted for histopathology through the Comparative Ocular Pathology Lab of Wisconsin. The histopathologic evaluation determined the mass to be consistent with an iris melanocytoma, which has not been previously reported in this species. The patient recovered well from surgery and has remained comfortable and active for 117 days post‐surgery. This case report aimed to review the current available information on avian ocular neoplasms as well as describe the clinical presentation, medical management and surgical procedure, and long‐term follow‐up for this patient to enhance clinical understanding of the behavior of iris melanocytic tumors in avian species.
Structural and Lithological Models of Ilmenite Placer Deposits in Ukraine
Authors: Ganzha Olena , Okholina Tetiana , Kroshko Yulia , Kuzmanenko Halyna , Kovalchuk Myron 
Published: August 2023

Since the 1950s, a large number of geological prospecting and exploration works have been carried out on the territory of Ukraine, dedicated to the search and exploration of placer titanium deposits. As a result, a powerful titanium raw material base has been created, in particular, titanium ore deposits with reserves and resources exceeding the total titanium reserves of all other countries of the world have been explored and prepared for exploration. The most promising deposits began to be developed and became the basis for the creation of the Irshanskiy mining and processing plant (Zhytomyr region) and the Vilnohirsk mining and metallurgical plant (Dnipropetrovsk region). The relevance of the presented subject is conditioned upon the need to use the latest information support tools to improve the quality of processing and presentation of geological information. The paper presents a summary lithostratigraphic scheme, features of the genesis and distribution of ore material (ilmenite) of the Krasnokutsk, Zlobychi, and Birzuliv deposits. These deposits are located in different parts (according to the tectonic division) of Ukraine, they have a diversified lithostratigraphy, geological and genetic types. Structural-lithological modelling of these objects is carried out. According to the presented structural and lithological models and paleogeographic reconstructions of the time of deposit formation, the change in ilmenite distribution depending on the type of placer formation is shown.
Toward Sustainable Manufacturing Facilities: Utilization of Solar Energy for Efficient Scheduling of Manufacturing Processes
Authors: Houchati Mahdi , Alabtah Fatima G. , Beitelmal AbdlMonem H. , Khraisheh Marwan 
Published: August 2023

Abstract
The utilization of solar energy as a renewable energy source has been a subject of interest for researchers in recent years. Despite recent advances in promoting solar energy, its intermittent and unpredictable nature limits its widespread utilization in manufacturing facilities. This research paper focuses on utilizing solar energy for efficient scheduling of manufacturing processes while keeping friendly environmental conditions for the workers. The work proposes an energy-aware dynamic scheduling procedure to minimize production and building costs by optimizing the utilization of an onsite photovoltaic (PV) system energy generation. The proposed method considers various factors such as the availability of solar energy, energy consumption of different manufacturing processes, and thermal requirements of the building. A stochastic energy prediction algorithm is developed to forecast the hourly one-day-ahead solar resources based on year-long solar radiation observations collected from an outdoor solar test facility in Qatar. This study shows that using the forecasted PV output improves the overall efficiency of manufacturing processes and building thermal requirements, thus achieving up to a 20% reduction in energy costs. These findings help the development of sustainable manufacturing systems and decrease the negative environmental impacts from industries.
Moving to an Activity-Friendly Community Can Increase Physical Activity
Authors: Lee Chanam , Xu Minjie , Zhu Xuemei , Towne Samuel D. , Sang Huiyan , Lee Hanwool , Ory Marcia G. 
Published: August 2023

Background: Creating activity-friendly communities (AFCs) is an important strategy to increase physical activity (PA). While cross-sectional links between community environments and PA are well documented, their causal relationships remain insufficiently explored. Methods: Using the accelerometer and survey data collected from adults who moved to an AFC (cases) and similar non-AFC-residing adults who did not move (comparisons), this pre–post, case-comparison study examines if moving to an AFC increases PA. Data came from 115 participants (cases = 37, comparisons = 78) from Austin, Texas, who completed 2 waves of 1-weeklong data collection. Difference-in-difference analyses and fixed-effect models were used to test the significance of the pre–post differences in moderate-to-vigorous PA (MVPA) between cases and comparisons, for the full sample and the subsample of 37 pairs matched in key covariates using the Propensity Score Matching method. Results: Average treatment effect generated based on Propensity Score Matching and difference-in-difference showed that moving to this AFC led to an average of 10.88 additional minutes of daily MVPA (76.16 weekly minutes, P = .015). Fixed-effect models echoed the result with an increase of 10.39 minutes of daily MVPA after moving to the AFC. We also found that case participants who were less active at baseline and had higher income increased their MVPA more than their counterparts. Conclusions: This study showed that, among our study sample, moving to an AFC increased residents’ PA significantly when compared to their premove level and the comparison group. This causal evidence suggests the potential of AFCs as sustainable interventions for PA promotion.
Pangenome analysis provides insights into the genetic diversity, metabolic versatility, and evolution of the genus
Flavobacterium
Authors: Kim Minji , Cha In-Tae , Lee Ki-Eun , Li Meng , Park Soo-Je 
Published: August 2023

ABSTRACT

Members of the genus
Flavobacterium
are widely distributed and produce various polysaccharide-degrading enzymes. Many species in the genus have been isolated and characterized. However, few studies have focused on marine isolates or fish pathogens, and in-depth genomic analyses, particularly comparative analyses of isolates from different habitat types, are lacking. Here, we isolated 20 strains of the genus from various environments in South Korea and sequenced their full-length genomes. Combined with published sequence data, we examined genomic traits, evolution, environmental adaptation, and putative metabolic functions in total 187 genomes of isolated species in
Flavobacterium
categorized as marine, host-associated, and terrestrial including freshwater. A pangenome analysis revealed a correlation between genome size and coding or noncoding density.
Flavobacterium
spp. had high levels of diversity, allowing for novel gene repertories via recombination events. Defense-related genes only accounted for approximately 3% of predicted genes in all
Flavobacterium
genomes. While genes involved in metabolic pathways did not differ with respect to isolation source, there was substantial variation in genomic traits; in particular, the abundances of tRNAs and rRNAs were higher in the host-associdated group than in other groups. One genome in the host-associated group contained a
Microviridae
prophage closely related to an enterobacteria phage. The proteorhodopsin gene was only identified in four terrestrial strains isolated for this study. Furthermore, recombination events clearly influenced genomic diversity and may contribute to the response to environmental stress. These findings shed light on the high genetic variation in
Flavobacterium
and functional roles in diverse ecosystems as a result of their metabolic versatility.

IMPORTANCE

The genus
Flavobacterium
is a diverse group of bacteria that are found in a variety of environments. While most species of this genus are harmless and utilize organic substrates such as proteins and polysaccharides, some members may play a significant role in the cycling for organic substances within their environments. Nevertheless, little is known about the genomic dynamics and/or metabolic capacity of
Flavobacterium
. Here, we found that
Flavobacterium
species may have an open pangenome, containing a variety of diverse and novel gene repertoires. Intriguingly, we discovered that one genome (classified into host-associated group) contained a
Microviridae
prophage closely related to that of enterobacteria. Proteorhodopsin may be expressed under conditions of light or oxygen pressure in some strains isolated for this study. Our findings significantly contribute to the understanding of the members of the genus
Flavobacterium
diversity exploration and will provide a framework for the way for future ecological characterizations.
Surgical Inflammation Alters Immune Response to Intraoperative Photodynamic Therapy
Authors: Davis Richard W. , Klampatsa Astero , Cramer Gwendolyn M. , Kim Michele M. , Miller Joann M. , Yuan Min , Houser Cassandra , Snyder Emma , Putt Mary , Vinogradov Sergei A. , Albelda Steven M. , Cengel Keith A. , Busch Theresa M. 
Published: August 2023

Surgical cytoreduction for patients with malignant pleural mesothelioma (MPM) is used for selected patients as a part of multi-modality management strategy. Our group has previously described the clinical use of photodynamic therapy (PDT), a form of non-ionizing radiation, as an intraoperative therapy option for MPM. Although necessary for the removal of bulk disease, the effects of surgery on residual MPM burden are not understood. In this bedside-to-bench study, Photofrin-based PDT introduced the possibility of achieving a long-term response in murine models of MPM tumors that were surgically debulked by 60% to 90%. Thus, the addition of PDT provided curative potential after an incomplete resection. Despite this success, we postulated that surgical induction of inflammation may mitigate the comprehensive response of residual disease to further therapy. Utilizing a previously validated tumor incision (TI) model, we demonstrated that the introduction of surgical incisions had no effect on acute cytotoxicity by PDT. However, we found that surgically induced inflammation limited the generation of antitumor immunity by PDT. Compared with PDT alone, when TI preceded PDT of mouse tumors, splenocytes and/or CD8+ T cells from the treated mice transferred less antitumor immunity to recipient animals. These results demonstrate that addition of PDT to surgical cytoreduction significantly improves long-term response compared with cytoreduction alone, but at the same time, the inflammation induced by surgery may limit the antitumor immunity generated by PDT. These data inform future potential approaches aimed at blocking surgically induced immunosuppression that might improve the outcomes of intraoperative combined modality treatment.

Significance:
Although mesothelioma is difficult to treat, we have shown that combining surgery with a form of radiation, photodynamic therapy, may help people with mesothelioma live longer. In this study, we demonstrate in mice that this regimen could be further improved by addressing the inflammation induced as a by-product of surgery.