bluuebunny/crossref_metadata_2025_split huggingface dataset:
Precipitation, rather than temperature drives coordination of multidimensional root traits with ectomycorrhizal fungi in alpine coniferous forests
Authors: Ding Junxiang , Yin Huajun , Kong Deliang , Liu Qing , Zhang Ziliang , Wang Qitong , Guo Wanji , Valverde‐Barrantes Oscar J. , Wang Junjian , Liu Zhanfeng 
Published: June 2023

Abstract

The interactions between roots and mycorrhizal fungi are critical for our understanding of the multidimensional root economics space. Our knowledge on their relationships comes mainly from arbuscular mycorrhizal (AM) plants, and less is known about how roots are coordinated with ectomycorrhizal (ECM) fungal communities, especially in ECM‐dominated alpine forests that are highly sensitive to climate change worldwide.

Here, we investigated the coordination between roots and ECM fungi and their drivers by measuring multiple root traits, ECM fungal composition and environmental factors of 47 coniferous populations across the alpine coniferous forests on the Tibetan Plateau.

Our results reveal two independent fine‐root trait dimensions, that is root foraging dimension and root uptake dimension, which are represented by root diameter‐specific root length, root tissue density‐root N concentration. Importantly, the hyphal exploration type based ECM foraging correlated significantly with both root foraging and root uptake dimension. Further, in the low temperature plateau, it is precipitation‐induced changes in soil moisture, soil nutrients and pH that drive the proportion of longer‐distance hyphal exploration types to increase with higher root foraging by higher specific root length, and to decrease with higher uptake by higher root N concentration.

Synthesis. The coordination of multidimensional root traits with ECM fungi differs greatly from the well‐recognized pattern in AM plants that mycorrhizal fungi connect predominantly with root foraging and that roots and mycorrhizal fungi are temperature sensitive. These findings provide a new insight for our holistic understanding of how roots and mycorrhizal fungi vary collaboratively and hence driving plant community assembly and responses to the changing climate.
Assessment of environmental footprint using geospatial approach to ascertain the Sustainable Development Goal 2030s of India
Authors: Sharma Laxmi Kant , Aarav Pranjal , Sharma Shweta , Raj Alok 
Published: June 2023

AbstractUtilization of natural resources has multiplied globally, resulting in serious environmental deterioration and impeding the achievement of the Sustainable Development Goals (SDGs). For the harmonious development of human nourishment and the balance of nature, it is vital to evaluate environmental segments' resource usage, transformation, and residue, referred to as ‘footprint,’ in order to highlight carrying capacity and sustainability. This analysis highlights the Environmental Footprint (EF) of India per state from 2010 to 2020 in terms of hectares per capita. This study evaluates India's biological, hydrological, energy, ecological, and pollution footprints, carrying capacity, environmental pressure, and environmental deficit using 17 distinct parameters categorized under the themes of biological resource, hydrological resource, energy resource, and pollution concentration. We proposed a reoriented methodology and EF concepts that determine India's footprint, carrying capacity, nature of sustainability, environmental pressure index, and its consequential links to the 2030 SDGs. As a result, the biological resources contributed to ~50% of the environmental footprint, while hydrological, energy, and pollutants made up the remaining. Between 2010 and 2020, Delhi, Uttar Pradesh, Bihar, and West Bengal had the highest EF, while Jammu and Kashmir and the north‐eastern provinces had the lowest. During the research period, the ecological deficit in India has increased overall. India impedes the 2030 SDGs; therefore, the study provides a picture of resource consumption, waste generation, economic growth, and societal changes, enabling academics and policymakers to redefine or document policy for a more sustainable future.
Inflammatory response after out‐of‐hospital cardiac arrest—Impact on outcome and organ failure development
Authors: Seppä Asser M. J. , Skrifvars Markus B. , Pekkarinen Pirkka T. 
Published: June 2023

AbstractBackgroundPost‐cardiac arrest syndrome that occurs in out‐of‐hospital cardiac arrest (OHCA) patients is characterized by inflammatory response. We conducted a scoping review of current evidence regarding several inflammatory markers' usefulness for assessment of patient outcome and illness severity. We also discuss the proposed underlying mechanisms leading to inflammatory response after OHCA.MethodsWe searched the MEDLINE, PubMed Central, Cochrane CENTRAL and Web of Science Core Collection databases with the following search terms: (“inflammation” OR “cytokines”) AND “out‐of‐hospital cardiac arrest.” Each inflammatory marker found was combined with “out‐of‐hospital cardiac arrest” using “AND” to find further relevant studies. We included original studies measuring inflammatory markers in adult OHCA patients that assessed their prognostic capabilities for mortality, neurological outcome, or organ failure severity.ResultsFifty‐nine studies met the inclusion criteria, covering in total 65 different markers. Interleukin‐6 (IL‐6), procalcitonin (PCT) and C‐reactive protein (CRP) were the most studied markers, and they were associated with poor outcomes in 13/15, 13/14 and 11/17 studies, respectively. Based on area under the receiver operating characteristic curve (AUC) value, the time point of best discriminatory capacity for poor outcome was ICU admission for IL‐6 (median AUC 0.78, range 0.71–0.98) and day one after OHCA for PCT (median AUC 0.84, range 0.61–0.98). Seven studies reported AUCs for CRP (range 0.52–0.76) with no measurement time point being superior to others. The association of IL‐6 and PCT with outcome appeared stronger in studies with more severely ill patients. Studies reported conflicting results regarding each marker's association with organ failure severity.ConclusionInflammatory markers are potentially useful for early risk stratification after OHCA. PCT and IL‐6 have moderate prognostic value during the first 24 h of the ICU stay. Predictive accuracy appears to be associated with the study overall event rate.
Ancient white and grey marbles from Aphrodisias: multi‐method characterization
Authors: Wielgosz‐Rondolino Dagmara , Antonelli Fabrizio , Bojanowski Maciej J. , Degryse Patrick , Gładki Marcin , Göncüoğlu Mehmet Cemal , Lazzarini Lorenzo , Long Leah , Mandera Sara 
Published: June 2023

AbstractThe paper presents the results of the archaeometric investigation, conducted for the first time with the use of a wide range of analytical methods, on white and grey marbles exploited in the so‐called City and Regional Quarries of Aphrodisias (south‐western Turkey). The research, based on a multi‐method approach and performed on a representative set of samples, was aimed to provide a comprehensive evaluation of the most important properties of Aphrodisian marbles. The material studied here shows a large overlap in petrographic and geochemical features among the marbles exploited in local and regional quarries, as well as with most of the widespread marbles used in Antiquity. Surprisingly, none of the methods used here, either by themselves or used in combination, is sufficient to discriminate reliably between Aphrodisian and other marble types (mainly Paros‐Lakkoi and Prokonnesos), as well as between marbles extracted from the City and Regional Quarries. The only provenance indicator is the depleted δ13C values below +0.5‰ for the grey variety from sectors AF3 and AF9, which constitute 15% of collected samples. The presumed international use of Aphrodisian marbles may be difficult to verify based on these indistinct outcomes. Another important element of the study are the topographical measurements used to estimate the volume of extracted material.
Analyzing the implications of organic standardization and certification in alternative food networks: The capability approach
Authors: de Lima Felipe Alexandre , Neutzling Daiane Mülling , Seuring Stefan , Kumar Vikas , Bossle Marilia Bonzanini 
Published: June 2023

AbstractAlthough organic standards and certification schemes have a crucial role in ensuring quality, safety, and sustainability within food systems, there is a need to critically analyze their implications on human capabilities within alternative food networks (AFNs). Therefore, this paper draws upon the capability approach to analyze the implications of three governance mechanisms (i.e., third‐party, social control, and hybrid certification) on human flourishing within AFNs in Ceará, Brazil. The three cases primarily build on 66 interviews with farmers, consumers, AFN owners and employees, certifying officials, governmental and non‐governmental representatives, and researchers. Third‐party certification has some positive effects in terms of material, political, and environmental capabilities and many negative effects regarding social/cultural capabilities. Social control certification bolsters material, social/cultural, political, and environmental capabilities for the benefit of farmers and consumers. Hybrid certification increases the material control, political power, social legitimacy, and environmental governance of market intermediaries. The findings can help scholars, practitioners, and policymakers rethink the role of organic standardization and certification in fostering fundamental human capabilities and tackling inequalities within AFNs.
Hydrogen sulfide signalling in neurodegenerative diseases
Authors: Tripathi Sunil Jamuna , Chakraborty Suwarna , Miller Emiko , Pieper Andrew A. , Paul Bindu D. 
Published: June 2023

AbstractThe gaseous neurotransmitter hydrogen sulfide (H2S) exerts neuroprotective efficacy in the brain via post‐translational modification of cysteine residues by sulfhydration, also known as persulfidation. This process is comparable in biological impact to phosphorylation and mediates a variety of signalling events. Unlike conventional neurotransmitters, H2S cannot be stored in vesicles due to its gaseous nature. Instead, it is either locally synthesized or released from endogenous stores. Sulfhydration affords both specific and general neuroprotective effects and is critically diminished in several neurodegenerative disorders. Conversely, some forms of neurodegenerative disease are linked to excessive cellular H2S. Here, we review the signalling roles of H2S across the spectrum of neurodegenerative diseases, including Huntington's disease, Parkinson's disease, Alzheimer's disease, Down syndrome, traumatic brain injury, the ataxias, and amyotrophic lateral sclerosis, as well as neurodegeneration generally associated with ageing.
BACH1 promotes lung adenocarcinoma cell metastasis through transcriptional activation of ITGA2
Authors: Chen Yingji , Jin Longyu , Ma Yuchao , Liu Yicai , Zhu Qianjun , Huang Yu , Feng Wei 
Published: June 2023

AbstractBACH1 plays an important role in promoting cancer. This study aims to further verify the relationship between the expression level of BACH1 in lung adenocarcinoma prognosis, as well as the influence of BACH1 expression on lung adenocarcinoma and the potential mechanism. The expression level of BACH1 in lung adenocarcinoma and its relationship with prognosis was evaluated by lung adenocarcinoma tissue microarray analysis combined with bioinformatics approaches. Gene knockdown and overexpression were used to investigate the functions and molecular mechanisms of BACH1 in lung adenocarcinoma cells. The regulatory downstream pathways and target genes of BACH1 in lung adenocarcinoma cells were explored by bioinformatics and RNA sequencing data analysis, real‐time PCR, western blot analysis, and cell immunofluorescence and cell adhesion assays. Chromatin immunoprecipitation and dual‐luciferase reporter assays were carried out to verify the target gene binding site. In the present study, BACH1 is abnormally highly expressed in lung adenocarcinoma tissues, and high BACH1 expression is negatively correlated with patient prognosis. BACH1 promotes the migration and invasion of lung adenocarcinoma cells. Mechanistically, BACH1 directly binds to the upstream sequence of the ITGA2 promoter to promote ITGA2 expression, and the BACH1‐ITGA2 axis is involved in cytoskeletal regulation in lung adenocarcinoma cells by activating the FAK‐RAC1‐PAK signaling pathway. Our results indicated that BACH1 positively regulates the expression of ITGA2 through a transcriptional mechanism, thereby activating the FAK‐RAC1‐PAK signaling pathway to participate in the formation of the cytoskeleton in tumor cells and then promoting the migration and invasion of tumor cells.
Attrition from paediatric weight management impacts anthropometric outcomes at 2 years, but not health‐related quality of life
Authors: Morrison Katherine M. , Gunn Elizabeth , Schwindt Stephanie , Hu Linda , Tarnopolsky Mark 
Published: June 2023

SummaryThe study objective is to evaluate the influence of attrition from a paediatric weight management program (PWM) on health indicators over a 2‐year period. In this observational study, children and youth with obesity were recruited at entry into a family‐based behaviour modification PWM and had four research study visits, independent of clinic visits, over 2 years. Participants were divided into attrition groups based on length of clinic enrolment. Body composition, cardiometabolic health and health‐related quality of life (HRQoL) were assessed. Among 269 children enrolled, 19% had no clinic treatment visit, 16% had treatment visits only up to 6 months, 23% up to 1 year and 42% had at least one clinic visit after 1 year (No Attrition). Greater declines in BMI z‐score and body fat were seen at 2 years in children with No Attrition, while improvements in HRQoL were similar for all attrition groups. Children who attended at least one treatment visit reported improved HRQoL up to 2 years, regardless of duration in clinic. In contrast, declines in body fat and BMI z‐score were greater at 2 years for those with at least one visit after 1 year. Continued efforts to reduce attrition are likely to improve anthropometric health outcomes during PWM.
Contact sensitisation in oral lichen planus: An Australian perspective
Authors: Ting Sarajane , Nguyen Jennifer , Palmer Amanda , Rosemary Nixon A. M. 
Published: June 2023

AbstractBackgroundThe role of contact sensitisation in the pathogenesis of oral lichen planus (OLP) has not been clearly defined.ObjectiveWe aimed to evaluate relevant contact sensitisers in OLP.MethodsA retrospective study was conducted on OLP patients who underwent patch testing from 1 January 2006 to 31 December 2020 at an Australian tertiary dermatology institution, compared to cheilitis patients patch tested over the same time period.ResultsNinety‐six OLP patients and 152 cheilitis patients were patch tested during the 15‐year period. Seventy‐one (73.9%) OLP patients and 100 (65.8%) cheilitis patients recorded one or more relevant reactions. Forty‐three (44.8%), 22 (22.9%), 21 (21.9%) and 17 (17.7%) OLP patients had relevant reactions to mercury‐related chemicals, amalgam, spearmint and carvone, respectively, compared to 6 (3.9%), 3 (2.0%), 4 (2.6%) and 0 (0%) cheilitis patients, respectively (p‐value <0.001 each). Four (4.2%) OLP patients had relevant positive reactions to sodium metabisulfite, compared to none in the cheilitis group (p‐value 0.021).ConclusionWhile dental amalgam is used less frequently these days, we report that mercury (found in amalgam) and additionally spearmint and carvone are relevant sensitisers in OLP in Australia. Sodium metabisulfite may also be a relevant sensitiser in OLP, which has not previously been reported.
Comparative study of different methods for the assessment of print nonuniformity and their correlation with the human visual system
Authors: Jurič Ivana , Zdravković Sunčica , Kašiković Nemanja , Dedijer Sandra , Pal Magdolna , Pavlović Živko , Karlovits Igor 
Published: June 2023

AbstractPrint nonuniformity is the variation of optical density (reflection) on the print and can occur in several different types that can be classified into two basic groups: random and systematic variations. This article examines two types from each group of variations that are most commonly found in digital printing systems: blotches and streaks, where amplitude and size were varied. Three most commonly used methods for measuring the print nonuniformity were used: Grey Level Co‐occurrence Matrix (GLCM), ISO 13660 and Integration (also Improved Integration) method. The results obtained by measuring were compared with a visual assessment to find the link between objective and subjective analysis and to define and determine which method/parameter is the best for the measurement of which type of print (non)uniformity. The obtained results indicate the possibility of selecting the measurement parameter, but that the choice of the parameter depends on the type of nonuniformity. It is concluded that in the case of the GLCM method, the entropy and energy parameters are strongly related to the visual assessment for all three sets of samples. These parameters can be used regardless of the type of nonuniformity. The ISO G parameter can be used to measure both graininess and mottling, while the ISO M parameter is only suitable for measuring mottling. Integration method could be used to measure systematic error. On the basis of conclusions of the research, it is possible to propose the development of an industrially applicable solution for measuring print nonuniformity of digitally printed samples.
Abemaciclib does not increase the corrected QT interval in healthy participants
Authors: Chappell Jill C. , Chiang Alan Y. , Royalty Jane , Coleman Hugh , Kulanthaivel Palaniappan , Turner P. Kellie 
Published: June 2023

AbstractAbemaciclib is an orally administered, potent, and selective small molecule inhibitor of cyclin‐dependent kinases 4 and 6, approved for advanced or metastatic breast cancer. This study aimed to use an exposure–response approach to investigate the effect of abemaciclib and its active metabolites (M2 and M20) on QTc interval and delay in cardiac repolarization at clinically relevant exposures. This was a single‐blind, randomized, and placebo‐controlled study of ascending doses of abemaciclib. Thirty‐five healthy participants were administered a single dose of 200–600 mg abemaciclib. Twelve‐lead electrocardiogram tracings and pharmacokinetic samples were collected serially pre‐ and post‐dose. The primary objective was to study the relationship between abemaciclib and its active metabolites (M2 and M20) and QTc interval following ascending oral doses of abemaciclib. The secondary objective included evaluating the safety and tolerability of single ascending doses of abemaciclib in healthy participants. Exposure–response analysis demonstrated that there was no significant relationship between placebo‐corrected change from baseline QTcF (ΔΔQTcF), abemaciclib, and metabolite plasma concentrations. Additionally, the ΔΔQTcF slopes of abemaciclib, its metabolites, and total analyte concentrations were not statistically different from zero. Single doses of abemaciclib, up to 400 mg, were well‐tolerated by healthy participants; however, at the 600 mg dose (three times the highest registered dose), the frequency and severity of treatment‐related gastrointestinal events (primarily diarrhea, nausea, and vomiting) increased. In conclusion, single doses of abemaciclib, up to 400 mg, had no statistically or clinically relevant effects on QTc, and abemaciclib was well tolerated up to a dose of 400 mg in this study.
Infants expect friends, but not rivals, to be happy for each other when they succeed
Authors: Smith‐Flores Alexis S. , Herrera‐Guevara Isabel A. , Powell Lindsey J. 
Published: June 2023

AbstractA friend telling you good news earns them a smile while witnessing a rival win an award may make you wrinkle your nose. Emotions arise not just from people's own circumstances, but also from the experiences of friends and rivals. Across three moderated, online looking time studies, we asked if human infants hold expectations about others’ vicarious emotions and if they expect those emotions to be guided by social relationships. Ten‐ and 11‐month‐old infants (N = 154) expected an observer to be happy rather than sad when the observer watched a friend successfully jump over a wall; infants looked longer at the sad response compared to the happy response. In contrast, infants did not expect the observer to be happy when the friend failed, nor when a different, rival jumper succeeded; infants’ looking times to the two emotion responses in these conditions were not reliably different. These results suggest that infants are able to integrate knowledge across social contexts to guide expectations about vicarious emotional responses. Here infants connected an understanding of agents’ goals and their outcomes with knowledge of social relationships to infer an emotion response. Biased concern for friends but not adversaries is not just a descriptive feature of human relationships, but an expectation about the social world present from early in development. Further, the successful integration of these information types welcomes the possibility that infants can jointly reason about goals, emotions, and social relationships under an intuitive theory of psychology.Research Highlights
11‐month‐old infants use knowledge of relationships to make inferences about others’ vicarious emotions.
In Experiment 1 infants expected an observer to respond happily to a friend's success but not their failure.
Experiments 2 and 3 varied the relationship between the observer and actor and found that infants’ expectation of vicarious happiness is strongest for positive relationships and absent for negative relationships.
The results may reflect an intuitive psychology in which infants expect friends to adopt concern for one another's goals and to thus experience one another's successes as rewarding.
Disordered eating behaviours in adolescents with type 1 diabetes can be influenced by their weight at diagnosis and rapid weight gain subsequently
Authors: Propper‐Lewinsohn Tamar , Gillon‐Keren Michal , Shalitin Shlomit , Elran‐Barak Roni , Yackobovitch‐Gavan Michal , Fayman Gila , David Maayan , Liberman Alon , Phillip Moshe , Oron Tal 
Published: June 2023

AbstractAimsTo assess the prevalence and disease‐related risk factors for disordered eating behaviours among adolescents with type 1 diabetes and also to search for risk factors at disease diagnosis that can predict the development of disordered eating behaviours.MethodsA retrospective observational study of 291 adolescents aged 15–19 years with type 1 diabetes who completed the Diabetes Eating Problem Survey‐Revised (DEPS‐R) as is routine in our diabetes clinic. The prevalence of disordered eating behaviours and risk factors for their development was assessed.ResultsIn 84 (28.9%) adolescents, disordered eating behaviours were found. Disordered eating behaviours were positively associated with female sex (β = 3.01 [SE = 0.97], p = 0.002), higher BMI‐Z score (β = 2.08 [SE = 0.49], p < 0.001), higher HbA1c (β = 0.19 [SE = 0.03], p < 0.001) and treatment with multiple daily injections of insulin (β = 2.19 [SE = 1.02], p = 0.032). At type 1 diabetes diagnosis, higher BMI‐Z score (β = 1.54 [SE = 0.63], p = 0.016) for those diagnosed before age 13 years and increased weight gain at 3 months post‐diagnosis (β = 0.88 [SE = 0.25], p = 0.001) in females diagnosed at age 13 years or older were found to be risk factors for disordered eating behaviours.ConclusionsDisordered eating behaviours are common among adolescents with type 1 diabetes and are associated with various parameters, including BMI at diagnosis and the rate of weight gain at 3 months post‐diagnosis in females. Our findings highlight the need for early preventive efforts for disordered eating behaviours and interventions to avoid late diabetes complications.