bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assisted gene flow from outcrossing shows the potential for genetic rescue in an endangered salmon population
Authors: Pregler Kasey C. , Obedzinski Mariska , Gilbert‐Horvath Elizabeth A. , White Benjamin , Carlson Stephanie M. , Garza John Carlos 
Published: December 2022

AbstractGenetic rescue has emerged as an important tool to prevent extinction and improve fitness of declining populations. In principle, genetic rescue increases genetic variation in a population through translocation of unrelated individuals from an outside source population. Genetic rescue remains uncommon in conservation management due to concerns about the risk of outbreeding depression. Lack of data evaluating success of genetic rescue interventions has hampered willingness to use this technique to improve the genetic viability of inbred, bottlenecked populations. Here, we evaluate the success of a genetic rescue intervention within the endangered Central California Coast Coho Salmon Evolutionarily Significant Unit using ∼17 years of genetic and demographic data, including pre‐ and postoutcrossing with fish from a nearby watershed. We assessed fitness of outcrossed F1 and F2 progeny in a captive setting, and then used mark–recapture to estimate survival of juveniles released into streams. We found that outcrossing decreased relatedness among adults, and their hybrid progeny had higher fitness in both captive and stream settings relative to nonhybrids. Importantly, we did not observe evidence of outbreeding depression in either the F1 or F2 generations. This study highlights that genetic rescue can be a useful tool in the conservation of imperiled salmonids.
Farmer Lifeways and the Lived Experience of Adaptation to Water Policy Change in Idaho's Eastern Snake Plain Aquifer Region
Authors: du Bray Margaret V. , Burnham Morey , Running Katrina , Quimby Barbara 
Published: December 2022

AbstractAnthropologists developed the lifeways construct to understand how communities make a way of life on certain landscapes. In this paper, we pair the lifeways construct with that of “lived experiences” to include processes of change in lifeways. Using a case study of farmers in Idaho's Eastern Snake Plain Aquifer region, we explore farmers' efforts to adapt to changes in agricultural water policy. Based on interviews with farmers, we identify several components of farmers' lifeways, including place‐based identity, stewardship, trust in decision‐makers, and financial well‐being. Our findings suggest that the relationships between farmers and their landscapes are shifting as a result of water governance changes. When combined with dynamic global economic factors, ever‐shifting regulatory and governance priorities and social‐ecological changes are likely to continue producing new and interacting challenges to which farmers—and their lifeways—will need to adapt to survive.
The competition–compensation account of developmental language disorder
Authors: Harmon Zara , Barak Libby , Shafto Patrick , Edwards Jan , Feldman Naomi H. 
Published: December 2022

AbstractChildren with developmental language disorder (DLD) regularly use the bare form of verbs (e.g., dance) instead of inflected forms (e.g., danced). We propose an account of this behavior in which processing difficulties of children with DLD disproportionally affect processing novel inflected verbs in their input. Limited experience with inflection in novel contexts leads the inflection to face stronger competition from alternatives. Competition is resolved through a compensatory behavior that involves producing a more accessible alternative: in English, the bare form. We formalize this hypothesis within a probabilistic model that trades off context‐dependent versus independent processing. Results show an over‐reliance on preceding stem contexts when retrieving the inflection in a model that has difficulty with processing novel inflected forms. We further show that following the introduction of a bias to store and retrieve forms with preceding contexts, generalization in the typically developing (TD) models remains more or less stable, while the same bias in the DLD models exaggerates difficulties with generalization. Together, the results suggest that inconsistent use of inflectional morphemes by children with DLD could stem from inferences they make on the basis of data containing fewer novel inflected forms. Our account extends these findings to suggest that problems with detecting a form in novel contexts combined with a bias to rely on familiar contexts when retrieving a form could explain sequential planning difficulties in children with DLD.Research Highlights
Generalization difficulties with inflectional morphemes in children with Developmental Language Disorder arise from these children's limited experience with novel inflected forms.
Limited experience with a form in novel contexts could lead to a storage bias where retrieving a form often requires relying on familiar preceding stems.
While generalization in typically developing models remains stable across a range of model parameters, certain parameter values in the impaired models exaggerate difficulties with generalization.
Children with DLD compensate for these retrieval difficulties through accessibility‐driven language production: they produce the most accessible form among the alternatives.
In the Lap of Collective Impotentiality: Reexamining a Pragmatic Account of Thinking Through an Agambenian Lens
Authors: Vlieghe Joris 
Published: December 2022

AbstractThe background of the argument Joris Vlieghe develops in this article is the idea, proposed by neopragmatic scholars, that a way of aptly dealing with the societal issues that have come about in the wake of a global ecological crisis consists of engaging in practices of study. This involves thinking, a concept that needs to be reconsidered from an educational perspective. Hence the article turns to John Dewey's classical pragmatic account of thinking, so as to show that this Deweyan approach could be enriched by reading it together with Giorgio Agamben's reflections on this matter. This allows for rendering with greater accuracy certain aspects of thinking that unearth its properly educational meaning: that thinking is necessarily a collective endeavor that is driven by an interruption of our habitual ways of living together with a view toward envisaging truly alternative futures. Thinking is a risky experience in which the foundational subject disappears. Such a view allows, furthermore, for the reconceptualization of thinking in a posthumanist key.
“Making Education Possible Again”: Pragmatist Experiments for a Troubled and Down‐to‐Earth Pedagogy
Authors: Thoilliez Bianca 
Published: December 2022

AbstractIn this article, Bianca Thoilliez draws on pragmatist notions of fallibilism and pluralism to develop proposals for possible educational interventions to address the problem of “post‐truth” conditions. Post‐truth, she contends, is not only a political danger for liberal democracies, but it also poses a serious threat of extinction for our educational practices. With the help of some of Bruno Latour's and Danna Haraway's categories, and with the narrative intervention of Gerald Durrell's My Family and Other Animals, Thoilliez attempts to adapt both Charles Peirce's and William James's classic pragmatist ideas in order to experiment with new horizons of thought capable of overcoming the exhausted pedagogical divides of docility/indocility, conserve/discard, and optimism/pessimism that often seem woven into the definition of educational relationships, the establishment of curriculum content, and the orientation of pedagogical actions. As an alternative, she recommends building communitarian alliances of fallibilistic inquiry and promoting practices of pluralistic cultural provision as more useful educational ends‐in‐view that embody a down‐to‐earth pedagogy capable of reinstating trust, taking care of truths, looking for ways of keeping our lives together, and making education possible again. Thus, here Thoilliez proposes a pedagogy that neither fixes nor evades our troubles, but one that stays with them.
Evolution of developmental plasticity and the potential of host shift in the seed beetle: Insights from laboratory evolution experiments
Authors: Savković Uroš , Đorđević Mirko , Vlajnić Lea , Budečević Sanja , Stojković Biljana 
Published: December 2022

Abstract
Expansion of the host range in phytophagous insects, followed by the specialisation on novel hosts, encompasses changes in many aspects of insects' behaviour, physiology, and the interaction between their life‐history features.
Here, we analyse the roles of insects' developmental plasticity in the process of host shift. Using laboratory populations of the seed beetle (Acanthoscelides obtectus), which have evolved on both optimal (common beans) and suboptimal (chickpea) plant hosts for more than 35 years, we experimentally replicated the process of host shift and analysed the patterns of short‐term and long‐term life‐history responses to host variation.
In order to test whether selection for increased plasticity has an effect on host shifting processes, we used existing bean and chickpea adapted populations to establish new populations in which the host plant offered for insect development was changed each generation (for 13 generations). To test the potential for a short‐term plastic response, beetles from each laboratory population were raised on both hosts for one generation.
Results showed that, in contrast to the populations that evolved on beans, which maintained high levels of developmental plasticity, long‐term host switching to chickpeas was accompanied with specialisation of pre‐adult viability with a simultaneous increase in fecundity. Populations evolved on alternate plant hosts that revealed similar plasticity patterns as their ancestral populations.
These results suggest that short‐term plastic responses could determine the paths of long‐term evolution of life‐history plasticity. However, more time could be needed for plasticity to evolve differently from the initial responses.
The development of a dental light curable PRFe‐loaded hydrogel as a potential scaffold for pulp‐dentine complex regeneration: An in vitro study
Authors: Noohi Parisa , Abdekhodaie Mohammad J. , Saadatmand Maryam , Nekoofar Mohammad H. , Dummer Paul M. H. 
Published: December 2022

AbstractAimThe study aimed to develop a bicomponent bioactive hydrogel formed in situ and enriched with an extract of platelet‐rich fibrin (PRFe) and to assess its potential for use in pulp‐dentine complex tissue engineering via cell homing.MethodologyA bicomponent hydrogel based on photo‐activated naturally derived polymers, methacrylated chitosan (ChitMA) and methacrylated collagen (ColMA), plus PRFe was fabricated. The optimized formulation of PRFe‐loaded bicomponent hydrogel was determined by analysing the mechanical strength, swelling ratio and cell viability simultaneously. The physical, mechanical, rheological and morphological properties of the optimal hydrogel with and without PRFe were determined. Additionally, MTT, phalloidin/DAPI and live/dead assays were carried out to compare the viability, cytoskeletal morphology and migration ability of stem cells from the apical papilla (SCAP) within the developed hydrogels with and without PRFe, respectively. To further investigate the effect of PRFe on the differentiation of encapsulated SCAP, alizarin red S staining, RT‐PCR analysis and immunohistochemical detection were performed. Statistical significance was established at p <  .05.ResultsThe optimized formulation of PRFe‐loaded bicomponent hydrogel can be rapidly photocrosslinked using available dental light curing units. Compared to bicomponent hydrogels without PRFe, the PRFe‐loaded hydrogel exhibited greater viscoelasticity and higher cytocompatibility to SCAP. Moreover, it promoted cell proliferation and migration in vitro. It also supported the odontogenic differentiation of SCAP as evidenced by its promotion of biomineralization and upregulating the gene expression for ALP, COL I, DSPP and DMP1 as well as facilitated angiogenesis by enhancing VEGFA gene expression.ConclusionsThe new PRFe‐loaded ChitMA/ColMA hydrogel developed within this study fulfils the criteria of injectability, cytocompatibility, chemoattractivity and bioactivity to promote odontogenic differentiation, which are fundamental requirements for scaffolds used in pulp‐dentine complex regeneration via cell‐homing approaches.
Association of class II HLA alleles with susceptibility to develop immune‐mediated diseases in Paraguayan patients
Authors: Acosta‐Colman Isabel , Cabrera‐Villalba Sonia , Ayala‐Lugo Ana , Jolly Valerie , Vazquez Marcos , Morel Zoilo , Langjahr Patricia , Duarte Margarita , Zarate Ruth , Acosta Maria Eugenia , Avila‐Pedretti Gabriela , Julià Antonio , Martinez María Teresa , Marsal Sara 
Published: December 2022

AbstractGenetic and nongenetic factors are involved in the pathogenesis of immune‐mediated inflammatory diseases (IMIDs). The best‐known genetic factor for susceptibility to IMIDs is the human leukocyte antigen (HLA). The aim of the present study was to evaluate the association of HLA class II genes with the risk of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc) in the Paraguayan population. We included 254 patients with IMIDs (101 SLE, 103 RA, and 50 SSc) and 50 healthy controls. The haplotypes of five genes corresponding to HLA class II genes and their relationship to the IMIDs studied were determined. Note that 84.6% were women, with a mean age of 43.4 ± 14 years. Among the associated HLA alleles, we found the previously identified risk factors in other populations like HLA‐DRB1*03:01 and HLA‐DRB1*14:02 for RA, as well as new ones not previously identified, such as DPA1*02:01 for SLE and, DB1*02:01 for RA and SSc. In the genetic association analysis, already known associations have been replicated, and unpublished associations have been identified in Paraguayan patients with IMIDs. This is the first genetic association study in Paraguayan patients with IMIDs.
Prevention of breast cancer‐related lymphoedema: Quality of clinical practice guidelines and variations in recommendations
Authors: Li Mingzhen , Liu Boxuan , Chen Cheng , Liu Huan , He Shaohua , Sun Weihua , Yan Qiang , Rao Xiaohua , Jin Yinghui , Tan Liming 
Published: December 2022

AbstractAimWe aimed to evaluate the quality of clinical practice guidelines (CPGs) for breast cancer related lymphoedema (BCRL) and compare the similarities and differences in recommendations.BackgroundMany CPGs of BCRL have been developed; however, their recommendations and quality are controversial.MethodsRelevant papers were retrieved from electronic databases, professional associations and guideline development organizations, from 1 January 2015 to 30 September 2021. The Appraisal of Guidelines Research and Evaluation (AGREE) II instrument was used to evaluate the quality of the guidelines. Intraclass correlation coefficient (ICC) analysis was used to evaluate the overall consistency among evaluators.ResultsEight CPGs were included. The ICC values evaluation for CPGs ranged from 0.76 to 0.95, with good consensus among evaluators. The highest median score was 68.75% (61.46, 72.22%) for clarity, and the lowest was 37.50% (25.78, 51.30%) for applicability. The NICE, ACS/ACSO and APTA CPGs were rated well in most areas. Professional health education, individualized exercise programme and regular surveillance are the main methods to prevent lymphoedema.ConclusionIn the past 6 years, the quality of BCRL guidelines has varied greatly, especially in the domains of rigour and applicability. Interrater agreement was excellent, but recommendation showed some inconsistencies in the details.
Effect of baroreflex activation therapy on dipping pattern in patients with resistant hypertension
Authors: Wallbach Manuel , Born Ellen , Schäfer Ann‐Kathrin , Koziolek Michael J. 
Published: December 2022

AbstractA relevant number of patients with resistant hypertension do not achieve blood pressure (BP) dipping during nighttime. This inadequate nocturnal BP reduction is associated with elevated cardiovascular risks. The aim of this study was to evaluate whether a nighttime intensification of BAT might improve nocturnal BP dipping. In this prospective observational study, non‐dippers treated with BAT for at least 6 months were included. BAT programming was modified in a two‐step intensification of nighttime stimulation at baseline and week 6. Twenty‐four hours ambulatory BP (ABP) was measured at inclusion and after 3 months. A number of 24 patients with non‐ or inverted dipping pattern, treated with BAT for a median of 44 months (IQR 25–52) were included. At baseline of the study, patients were 66 ± 9 years old, had a BMI of 33 ± 6 kg/m2, showed an office BP of 135 ± 22/72 ± 10 mmHg, and took a median number of antihypertensives of 6 (IQR 4–9). Nighttime stimulation of BAT was adapted by an intensification of pulse width from 237 ± 161 to 267 ± 170 μs (p = .003) while frequency (p = .10) and amplitude (p = .95) remained unchanged. Uptitration of BAT programming resulted in an increase of systolic dipping from 2 ± 6 to 6 ± 8% (p = .03) accompanied with a significant improvement of dipping pattern (p = .02). Twenty four hours ABP, day‐ and nighttime ABP remained unchanged. Programming of an intensified nighttime BAT interval improved dipping profile in patients treated with BAT, while the overall 24 h ABP did not change. Whether the improved dipping response contributes to a reduction of cardiovascular risk beyond the BP‐lowering effects of BAT, however, remains to be shown.
Sustained cannabis use does not predispose clinical hypertension: Findings from a national survey
Authors: Shah Rohan M. , Patel Shiv , Shah Sareena , Doshi Sahil , Li Angela , Diamond Joseph A. 
Published: December 2022

AbstractCannabis is among the most used recreational and medicinal drugs in the United States. The effects of chronic use on hypertension remain poorly understood. Our study retrospectively evaluated data collected by the National Health and Nutrition Examination Survey from 2017 to 2018. Cannabis use was measured with five metrics: (1) sustained use at any point in the past, (2) sustained use within the past year, (3) frequency of use, (4) age of first cannabis use, and (5) current use. Hypertension status was determined by individuals reporting having been diagnosed in the past. Multivariable logistic regressions were performed, controlling for age, race, and gender. A total of 4565 respondents were identified, of which 867 (19.0%) reported sustained cannabis use in the past. Participants who reported past sustained cannabis use did not have statistically different odds of having hypertension (OR: 1.12; 95% CI: .66–1.91; p = .6). Moderate (OR: 1.08; 95% CI: .36–3.25; p = .8) and highly‐frequent users (OR: 1.30; 95% CI: .56–3.03; p = .4) did not have different odds of having hypertension than infrequent users. No relationship between the age of first cannabis use and hypertension was observed. The recency of sustained cannabis use was not associated with hypertension status. Current cannabis users had similar odds of hypertension as past users (OR: 1.03; 95% CI: .59–1.79; p = .9). The findings of this study indicate that neither past nor current cannabis use is associated with clinical hypertension.
Bait‐ER: A Bayesian method to detect targets of selection in Evolve‐and‐Resequence experiments
Authors: Barata Carolina , Borges Rui , Kosiol Carolin 
Published: December 2022

AbstractFor over a decade, experimental evolution has been combined with high‐throughput sequencing techniques. In so‐called Evolve‐and‐Resequence (E&R) experiments, populations are kept in the laboratory under controlled experimental conditions where their genomes are sampled and allele frequencies monitored. However, identifying signatures of adaptation in E&R datasets is far from trivial, and it is still necessary to develop more efficient and statistically sound methods for detecting selection in genome‐wide data. Here, we present Bait‐ER – a fully Bayesian approach based on the Moran model of allele evolution to estimate selection coefficients from E&R experiments. The model has overlapping generations, a feature that describes several experimental designs found in the literature. We tested our method under several different demographic and experimental conditions to assess its accuracy and precision, and it performs well in most scenarios. Nevertheless, some care must be taken when analysing trajectories where drift largely dominates and starting frequencies are low. We compare our method with other available software and report that ours has generally high accuracy even for trajectories whose complexity goes beyond a classical sweep model. Furthermore, our approach avoids the computational burden of simulating an empirical null distribution, outperforming available software in terms of computational time and facilitating its use on genome‐wide data. We implemented and released our method in a new open‐source software package that can be accessed at https://doi.org/10.5281/zenodo.7351736.
Not just the sum of its parts: Geographic variation and nonadditive effects of pyrazines in the chemical defence of an aposematic moth
Authors: Ottocento Cristina , Winters Anne E. , Rojas Bibiana , Mappes Johanna , Burdfield-Steel Emily 
Published: December 2022

Abstract
Chemical defences often vary within and between populations both in quantity and quality, which is puzzling if prey survival is dependent on the strength of the defence. We investigated the within- and between-population variability in chemical defence of the wood tiger moth (Arctia plantaginis). The major components of its defences, SBMP (2-sec-butyl-3-methoxypyrazine) and IBMP (2-isobutyl-3-methoxypyrazine), are volatiles that deter bird attacks. We hypothesized that (1) variation in the chemical defences of male wood tiger moths reflects the local predation pressure; (2) observed differences in quantity and quality of defence among populations have a genetic basis; and (3) increasing concentrations of SBMP and IBMP will elicit greater aversive reactions in predators, with the two pyrazines having an additive effect on predators' avoidance. We found that (1) the chemical defence of wild moths partly reflects local predator selection: high predation pressure populations (Scotland and Georgia) had stronger chemical defences, but not lower variance, than the low-predation populations (Estonia and Finland). (2) Based on the common garden results, both genetic and environmental components seem to influence the strength of chemical defence in moth populations; and (3) IBMP alone did not provide protection against bird predators but worked against bird attacks only when combined with SBMP, and while SBMP was more effective at higher concentrations, IBMP was not. Altogether this suggests that, when it comes to pyrazine concentration, more is not always better, highlighting the importance of testing the efficacy of chemical defence and its components with relevant predators, as extrapolating from chemical data may be less than straightforward.
Abstract
We investigated the within- and between-population variability in chemical defence of the wood tiger moth (Arctia plantaginis). The major components of its defences, SBMP (2-sec-butyl-3-methoxypyrazine) and IBMP (2-isobutyl-3-methoxypyrazine), are volatiles that deter bird attacks. We found that (1) the chemical defence of wild moths partly reflects local predator selection; (2) both genetic and environmental components seem to influence the strength of chemical defence; and (3) IBMP alone did not provide protection against bird predators but worked against bird attacks only when combined with SBMP, and while SBMP was more effective at higher concentrations, IBMP was not. Altogether this suggests that, when it comes to pyrazine concentration, more is not always better, highlighting the importance of testing the efficacy of chemical defence with relevant predators.