bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern recognition reveals sex‐dependent neural substrates of sexual perception
Authors: Putkinen Vesa , Nazari‐Farsani Sanaz , Karjalainen Tomi , Santavirta Severi , Hudson Matthew , Seppälä Kerttu , Sun Lihua , Karlsson Henry K. , Hirvonen Jussi , Nummenmaa Lauri 
Published: February 2023

AbstractSex differences in brain activity evoked by sexual stimuli remain elusive despite robust evidence for stronger enjoyment of and interest toward sexual stimuli in men than in women. To test whether visual sexual stimuli evoke different brain activity patterns in men and women, we measured hemodynamic brain activity induced by visual sexual stimuli in two experiments with 91 subjects (46 males). In one experiment, the subjects viewed sexual and nonsexual film clips, and dynamic annotations for nudity in the clips were used to predict hemodynamic activity. In the second experiment, the subjects viewed sexual and nonsexual pictures in an event‐related design. Men showed stronger activation than women in the visual and prefrontal cortices and dorsal attention network in both experiments. Furthermore, using multivariate pattern classification we could accurately predict the sex of the subject on the basis of the brain activity elicited by the sexual stimuli. The classification generalized across the experiments indicating that the sex differences were task‐independent. Eye tracking data obtained from an independent sample of subjects (N = 110) showed that men looked longer than women at the chest area of the nude female actors in the film clips. These results indicate that visual sexual stimuli evoke discernible brain activity patterns in men and women which may reflect stronger attentional engagement with sexual stimuli in men.
Effects of 12‐week escitalopram treatment on resting‐state functional connectivity of large‐scale brain networks in major depressive disorder
Authors: Zhang Shudong , Zhou Jingjing , Cui Jian , Zhang Zhifang , Liu Rui , Feng Yuan , Feng Lei , Wang Yun , Chen Xiongying , Wu Hang , Jin Yuening , Zhou Yuan , Wang Gang 
Published: February 2023

AbstractIn this study, the effects of antidepressants on large‐scale brain networks and the neural basis of individual differences in response were explored. A total of 41 patients with major depressive disorder (MDD) and 42 matched healthy controls (HCs) were scanned by resting‐state functional magnetic resonance imaging separately at baseline and after a 12‐week follow‐up. The patients with MDD received escitalopram for 12 weeks. After treatment, patients were classified into those with MDD in remission [MDDr, endpoint 17‐item Hamilton Depression Rating Scale (HAMD) total score ≤7] and those in nonremission (MDDnr). The human Brainnetome Atlas was used to define large‐scale networks and compute within‐ and between‐network resting‐state functional connectivity (rsFC). Results showed the decreased subcortical network (SCN)–ventral attention network (VAN) connectivity at baseline increased in patients with MDD after 12‐week treatment, and it was comparable with that of HCs. This change was only observed in patients with MDDr. However, the decreased within‐network rsFC in SCN and default mode network (DMN) persisted in all patients with MDD, including those with MDDr and MDDnr, after treatment. The strength of SCN–VAN connectivity at baseline was significantly negatively correlated with the reduction rate of HAMD score in all patients with MDD. Thus, SCN–VAN connectivity may be an antidepressant target associated with depressive state changes and a predictor of treatment response to serotonin reuptake inhibitors. The within‐network rsFC in SCN and DMN may reflect a trait‐like abnormality in MDD. These findings provide further insights into the mechanism of antidepressants and their individual differences in response. The trial name is “Appropriate technology study of MDD diagnosis and treatment based on objective indicators and measurement” (URL: http://www.chictr.org.cn/showproj.aspx?proj=21377; registration number: ChiCTR‐OOC‐17012566).
Niobium‐containing bioactive glasses modulate alkaline phosphatase activity during bone repair
Authors: de Souza Balbinot Gabriela , Leitune Vicente Castelo Branco , da Cunha Bahlis Eduardo Antunes , Ponzoni Deise , Visioli Fernanda , Collares Fabrício Mezzomo 
Published: February 2023

AbstractThis study aimed to evaluate the pre‐clinical behavior of niobium‐containing bioactive glasses (BAGNb) by their ability to promote bone repair and regulate alkaline phosphatase (ALP) levels in an animal model. BAGNbs were produced as powders and as scaffolds and surgically implanted in the femur of male rats (Wistar lineage n = 10). Glasses without Nb (BAG) were produced and implanted as well. The Autogenous Bone (AB) was used as a control. After 15, 30, and 60 days of surgical implantation, blood serum samples were collected to quantify ALP activity, and femurs were removed to assess bone repair. Bone samples were histologically processed and stained with H&E to quantify the % new bone into defects. No postoperative complications were identified. Early‐stage repair (15 days) resulted in increased ALP activity for all groups, with increased values ​​for powdered BAGNb. The maturation of the new bone led to a reduction in serum ALP levels. Histological sections showed the formation of immature bone tissue and vascularization with the progression of bone deposition to mature and functional tissue over time. BAG powder showed less new bone formation in 15 days, while the analysis at 30 and 60 days showed no difference between groups (p > .05). Niobium‐containing bioactive glasses safely and successfully induced bone repair in vivo. The modulation of ALP activity may be a pathway to describe the ability of niobium‐containing materials to contribute to new bone formation.
Toward effective Atg8‐based ATTECs: Approaches and perspectives
Authors: Schwalm Martin P. , Knapp Stefan , Rogov Vladimir V. 
Published: February 2023

AbstractInduction of Atg8‐family protein (LC3/GABARAP proteins in human) interactions with target proteins of interest by proximity‐inducing small molecules offers the possibility for novel targeted protein degradation approaches. However, despite intensive screening campaigns during the last 5 years, no potent ligands for LC3/GABARAPs have been developed, rendering this approach largely unexplored and unsuitable for therapeutic exploitation. In this Viewpoint, we analyze the reported attempts identifying LC3/GABARAP inhibitors and provide our own point of view why no potent inhibitors have been found. Additionally, we designate reasonable directions for the identification of potent and probably selective LC3/GABARAP inhibitors for alternative therapeutic applications.
Pre‐COVID‐19 predictors of low‐income women's COVID‐19 appraisal, coping, and changes in mental health during the pandemic
Authors: Lengua Liliana J. , Stavish Caitlin M. , Green Lindsey M. , Shimomaeda Lisa , Thompson Stephanie F. , Calhoun Rebecca , Moini Natasha , Smith Michele R. 
Published: February 2023

AbstractStudy examined predictors and mental health consequences of appraisal (threat, support satisfaction) and coping (active, avoidant) in a sample of low‐income women during coronavirus disease 2019 (COVID‐19). Pre‐COVID‐19 contextual risk and individual resources and COVID‐19‐specific risk factors were examined as predictors of COVID‐19 appraisal and coping, which, in turn, were tested as predictors of changes in depression and anxiety across the pandemic. Pre‐COVID‐19 resilience predicted more active coping, whereas pre‐COVID‐19 anxiety and depression predicted more avoidant coping and lower support satisfaction, respectively. Increases in anxiety were predicted by lower pre‐COVID‐19 self‐compassion and higher concurrent threat appraisal and avoidant coping. Increases in depression were related to lower pre‐COVID‐19 self‐compassion, active coping and support satisfaction, and higher COVID‐19 hardships and health risk. Findings highlight contextual and individual factors and processes that contribute to mental health problems in a vulnerable population during community‐level stressors, with implications for prevention and intervention.
C‐terminal agrin fragment as a biomarker of muscle wasting and weakness: a narrative review
Authors: Monti Elena , Sarto Fabio , Sartori Roberta , Zanchettin Gianpietro , Löfler Stefan , Kern Helmut , Narici Marco Vincenzo , Zampieri Sandra 
Published: February 2023

AbstractAgeing is accompanied by an inexorable loss of muscle mass and functionality and represents a major risk factor for numerous diseases such as cancer, diabetes and cardiovascular and pulmonary diseases. This progressive loss of muscle mass and function may also result in the insurgence of a clinical syndrome termed sarcopenia, exacerbated by inactivity and disease. Sarcopenia and muscle weakness yield the risk of falls and injuries, heavily impacting on health and social costs. Thus, screening, monitoring and prevention of conditions inducing muscle wasting and weakness are essential to improve life quality in the ageing modern society. To this aim, the reliability of easily accessible and non‐invasive blood‐derived biomarkers is being evaluated. C‐terminal agrin fragment (CAF) has been widely investigated as a neuromuscular junction (NMJ)‐related biomarker of muscle dysfunction. This narrative review summarizes and critically discusses, for the first time, the studies measuring CAF concentration in young and older, healthy and diseased individuals, cross‐sectionally and in response to inactivity and physical exercise, providing possible explanations behind the discrepancies observed in the literature. To identify the studies investigating CAF in the above‐mentioned conditions, all the publications found in PubMed, written in English and measuring this biomarker in blood from 2013 (when CAF was firstly measured in human serum) to 2022 were included in this review. CAF increases with age and in sarcopenic individuals when compared with age‐matched, non‐sarcopenic peers. In addition, CAF was found to be higher than controls in other muscle wasting conditions, such as diabetes, COPD, chronic heart failure and stroke, and in pancreatic and colorectal cancer cachectic patients. As agrin is also expressed in kidney glomeruli, chronic kidney disease and transplantation were shown to have a profound impact on CAF independently from muscle wasting. CAF concentration raises following inactivity and seems to be lowered or maintained by exercise training. Finally, CAF was reported to be cross‐sectionally correlated to appendicular lean mass, handgrip and gait speed; whether longitudinal changes in CAF are associated with those in muscle mass or performance following physical exercise is still controversial. CAF seems a reliable marker to assess muscle wasting in ageing and disease, also correlating with measurements of appendicular lean mass and muscle function. Future research should aim at enlarging sample size and accurately reporting the medical history of each patient, to normalize for any condition, including chronic kidney disease, that may influence the circulating concentration of this biomarker.
Effects of corticosterone administration on the body condition and blood parameters of the house sparrow, Passer domesticus
Authors: Padrones Marcelo N. , Cid Fabricio D. , Chediack Juan G. 
Published: February 2023

AbstractGlucocorticoids are steroid hormones produced by the adrenal glands and released into the bloodstream in response to stressful situations. In birds, corticosterone (CORT) is the main glucocorticoid released under stress. Throughout their lives, animals in nature are continually exposed to noxious stimuli known as stressful events. Any alteration of homeostatic stability is a stressful situation and this alteration triggers physiological changes to restore homeostasis. Glucocorticoids are one of the components of the complex set of physiological and behavioral responses to stress. In this work, we use CORT supplied in drinking water to evaluate its effect in blood parameters and physiology in house sparrows (Passer domesticus). To accomplish this, P. domesticus were administered three different doses of CORT in drinking water for 72 h. Body mass, organ mass, pectoral muscle mass, leg muscle mass, and blood parameters (CORT, triglycerides, glucose and uric acid, heterophils/lymphocytes ratio, hematocrit, and serum protein profile) were determined before and after CORT treatment. A 15% decrease in body mass with a significant decrease in pectoral mass were observed after the higher CORT treatment, as well as a decrease in the plasma concentration of uric acid. Lastly, we found a reversal of the heterophils/lymphocytes ratio and a decrease in hematocrit. It was possible to establish first data for baseline and CORT‐alteration values in serum protein profile for P. domesticus. Baseline and altered values of blood parameters and serum protein profile could be an important tool in field ecology because they provide important data to assess the physiological condition in wild birds.
Short‐term impact of a wildfire on the homeostasis of Tropidurus oreadicus lizards
Authors: Furtado Adriana P. , Carvalho Izabelle T. S. , Lewis Erin L. , Bleke Cole A. , Pantoja Davi L. , Colli Guarino R. , French Susannah S. , Paludo Giane R. 
Published: February 2023

AbstractWildfires cause significant changes in natural habitats and can impact lizard populations. Through changes in the thermal environment, reduced prey availability, and increased exposure to parasite vectors, wildfires affect lizard physiology, immunity, and health. We sampled 56 Tropidurus oreadicus lizards from Cerrado savannas of Brazil living in two adjacent sites: one burned 14 days before the study, and the other unburned for 6 years. We logged the air temperatures of those sites throughout fieldwork. We assessed the short‐term possible homeostatic imbalances caused by the fires via measuring body mass, circulating levels of corticosterone (CORT), leukocytes profile changes in heterophile‐lymphocyte ratios (HLRs), innate immunity using the bacterial killing assay (BKA), and the diagnosis of hemoparasites using molecular techniques. The air temperature was significantly higher in the burned site. There was no difference in lizard body mass between the two sites, suggesting that prey availability was not affected by the wildfire. While parasite presence was seemingly not affected by fire, the timing of initial parasite infection for animals in the study was unknown, so we also evaluated parasitism as an independent variable relative to the other metrics. Our results showed that parasitic infections lead to reduced bactericidal capacity and body mass in lizards, suggesting clinical disease and depletion of innate immune resources. Moreover, we observed increased HLR with fire and parasitic infections and a strong negative correlation with BKA. These findings suggest that the increased environmental temperature following wildfires may lead to increased CORT and decreased BKA.
Adaptive changes in sexual behavior in the high‐risk population in response to human monkeypox transmission in Canada can help control the outbreak: Insights from a two‐group, two‐route epidemic model
Authors: Bragazzi Nicola Luigi , Han Qing , Iyaniwura Sarafa Adewale , Omame Andrew , Shausan Aminath , Wang Xiaoying , Woldegerima Woldegebriel Assefa , Wu Jianhong , Kong Jude Dzevela 
Published: February 2023

AbstractMonkeypox, a zoonotic disease, is emerging as a potential sexually transmitted infection/disease, with underlying transmission mechanisms still unclear. We devised a risk‐structured, compartmental model, incorporating sexual behavior dynamics. We compared different strategies targeting the high‐risk population: a scenario of control policies geared toward the use of condoms and/or sexual abstinence (robust control strategy) with risk compensation behavior change, and a scenario of control strategies with behavior change in response to the doubling rate (adaptive control strategy). Monkeypox's basic reproduction number is 1.464, 0.0066, and 1.461 in the high‐risk, low‐risk, and total populations, respectively, with the high‐risk group being the major driver of monkeypox spread. Policies imposing condom use or sexual abstinence need to achieve a 35% minimum compliance rate to stop further transmission, while a combination of both can curb the spread with 10% compliance to abstinence and 25% to condom use. With risk compensation, the only option is to impose sexual abstinence by at least 35%. Adaptive control is more effective than robust control where the daily sexual contact number is reduced proportionally and remains constant thereafter, shortening the time to epidemic peak, lowering its size, facilitating disease attenuation, and playing a key role in controlling the current outbreak.
Vibrational and electronic properties of Na2Ti6O13
Authors: Silva Fábio Lacerda Resende e , Ribeiro Guilherme Almeida Silva , Balzuweit Karla , Bantignies Jean‐Louis , Moreira Roberto Luiz , Righi Ariete 
Published: February 2023

AbstractSodium hexatitanate, Na2Ti6O13, in the form of elongated microcrystals, were synthesized by solid‐state reaction of titanium dioxide and sodium carbonate. The monoclinic structure was confirmed by X‐ray powder diffraction and selected area electron diffraction. Electron diffraction was used to determined zone axis and the crystal‐grown direction, which allowed to perform polarized Raman measurements. Energy band gap and the electronic transition were studied by UV–Vis diffuse reflectance and using Tauc relation. Density functional theory (DFT) calculations also revealed an indirect allowed bandgap transition and a good agreement between theoretical and experimental energy band gaps were demonstrated. For the first time, the assignment of the vibrational modes was carried out in the samples and thoroughly compared with theoretical data obtained from DFT calculations. The most relevant of the 60 predicted optical phonon modes of Na2Ti6O13were experimentally observed and assigned to their symmetries.
Neoadjuvant pazopanib in nonrhabdomyosarcoma soft tissue sarcomas (ARST1321): A report of major wound complications from the Children's Oncology Group and NRG Oncology
Authors: Kayton Mark L. , Weiss Aaron R. , Xue Wei , Binitie Odion , Hayes Dixon Andrea , Randall R. Lor , Sorger Joel I. , Hawkins Douglas S. , Spunt Sheri L. , Wang Dian , Million Lynn , Terezakis Stephanie , Choy Edwin , Okuno Scott H. , Venkatramani Rajkumar , Chen Yen‐Lin , Scharschmidt Thomas J. 
Published: February 2023

AbstractBackground and ObjectivesThe impact upon wound healing of targeted molecular therapies, when incorporated into neoadjuvant therapy of soft tissue sarcoma, is largely unknown. Here, we describe wound complications following addition of pazopanib, a tyrosine kinase inhibitor (TKI), to neoadjuvant radiotherapy (RT) +/− chemotherapy for soft tissue sarcoma.MethodsWound complications were evaluated on dose‐finding and randomized arms of ARST1321, a phase II/III study incorporating neoadjuvant RT, +/− pazopanib, +/− ifosfamide/doxorubicin (ID) for sarcoma therapy.ResultsOf 85 evaluable patients, 35 (41%) experienced postoperative wound complications. Most (57%) were grade III. Randomization to pazopanib + RT + ID carried a 50% wound complication rate (17/34, with 47% grade III), compared to 22% (5/23) with ID + RT alone. In nonchemotherapy study arms, pazopanib + RT resulted in a 59% wound complication rate versus 25% for those receiving RT alone. Grade III wound complications occurred among 26% (15/58) of all patients receiving pazopanib. Wound complications occurred a median of 35 days postoperatively. Some occurred following diagnostic biopsies and at remote surgical sites.ConclusionThe addition of pazopanib to neoadjuvant chemotherapy and RT resulted in a higher wound complication rate following therapy of soft tissue sarcoma. The rate of grade III complications remained comparable to that reported in contemporary literature.
Authors' choice between parent and mirror journals of Elsevier
Authors: Asai Sumiko 
Published: February 2023

Key points
2021, open access articles in parent journals with higher charges accounted for 72% of the total open access articles in parent and mirror journals.
Although the charges for mirror journals were significantly reduced in 2021, the increase in the number of articles was relatively small.
These findings suggest that many authors do not significantly respond to changes in article processing charges.
Quantifying uncertainty in Pareto estimates of global lake area
Authors: Stachelek Jemma 
Published: February 2023

AbstractSize is a critical factor determining the rate and occurrence of specific lake processes such as carbon sequestration and greenhouse gas emissions and emerging evidence suggests that small lakes in particular have particularly large CO2 flux rates. Because we do not have a complete census of all lakes, upscaling estimates of such processes to small lakes at broad spatial scales requires the use of lake size‐abundance distributions rather than empirical measurements of area. Existing lake census efforts are incomplete such that as lakes become smaller, they are more likely to be omitted either because they are too small to be resolved from remote sensing products or because of limited ground surveying effort (i.e., “censoring” of small lakes relative to large lakes). The present study explores one potential shortcoming of prior approaches estimating global lake area using lake size‐abundance distributions. Namely, that these prior approaches rely on frequentist curve fitting techniques combined with an ad‐hoc cutoff determination strategy (visual inspection to determine a likely censoring point). This yields an over‐exact lake area estimate that is typically reported with no uncertainty bounds. I show how these shortcomings can be addressed with a Bayesian model that produces larger estimates of lake area uncertainty relative to the typical approach. When used as part of a sensitivity analysis, such an approach has the potential to enable more robust intercomparisons among studies of aquatic processes upscaling.
Recent developments and applications of selected ion flow tube mass spectrometry (SIFT‐MS)
Authors: Smith David , Španěl Patrik , Demarais Nicholas , Langford Vaughan S. , McEwan Murray J. 
Published: February 2023

AbstractSelected ion flow tube mass spectrometry (SIFT‐MS) is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts‐per‐trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real‐time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial scenarios for air quality monitoring. This review touches on the recent extensions to the underpinning ion chemistry kinetics library and the alternative challenge of using nitrogen carrier gas instead of helium. The addition of reagent anions in the Voice200 series of SIFT‐MS instruments has enhanced the analytical capability, thus allowing analyses of volatile trace compounds in humid air that cannot be analyzed using reagent cations alone, as clarified by outlining the anion chemistry involved. Case studies are reviewed of breath analysis and bacterial culture volatile organic compound (VOC), emissions, environmental applications such as air, water, and soil analysis, workplace safety such as transport container fumigants, airborne contamination in semiconductor fabrication, food flavor and spoilage, drugs contamination and VOC emissions from packaging to demonstrate the stated qualities and uniqueness of the new generation SIFT‐MS instrumentation. Finally, some advancements that can be made to improve the analytical capability and reach of SIFT‐MS are mentioned.