bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal sevoflurane exposure induces neurotoxicity in offspring rats via the CB1R/CDK5/p-tau pathway
Authors: Wan Yuxiao , Wu Ziyi , Li Xingyue , Zhao Ping 
Published: January 2023

Sevoflurane is widely used for maternal anesthesia during pregnancy. Sevoflurane exposure of rats at mid-gestation can cause abnormal development of the central nervous system in their offspring. Sevoflurane is known to increase the expression of cannabinoid 1 receptor (CB1R) in the hippocampus. However, the effect of cannabinoid 1 receptor on fetal and offspring rats after maternal anesthesia is still unclear. At gestational day 14, pregnant rats were subjected to 2-h exposure to 3.5% sevoflurane or air. Rats underwent intraperitoneal injection with saline or rimonabant (1 mg/kg) 30 min prior to sevoflurane or air exposure. cannabinoid 1 receptor, cyclin-dependent kinase 5 (CDK5), p35, p25, tau, and p-tau expression in fetal brains was measured at 6, 12, and 24 h post-sevoflurane/air exposure. Neurobehavioral and Morris water maze tests were performed postnatal days 3–33. The expression of cannabinoid 1 receptor/cyclin-dependent kinase 5/p-tau and histopathological staining of brain tissues in offspring rats was observed. We found that a single exposure to sevoflurane upregulated the activity of cyclin-dependent kinase 5 and the level of p-tau via cannabinoid 1 receptor. This was accompanied by the diminished number of neurons and dendritic spines in hippocampal CA1 regions. Finally, these effects induced lower scores and platform crossing times in behavioral tests. The present study suggests that a single exposure to 3.5% sevoflurane of rats at mid-gestation impairs neurobehavioral abilities and cognitive memory in offspring. cannabinoid 1 receptor is a possible target for the amelioration of postnatal neurobehavioral ability and cognitive memory impairments induced by maternal anesthesia.
The efficacy of ginseng-containing traditional Chinese medicine in patients with acute decompensated heart failure: A systematic review and meta-analysis
Authors: Chen Xiaozhe , Ma Yulong , Li Jianhua , Yao Lei , Gui Mingtai , Lu Bo , Zhou Xunjie , Wang Mingzhu , Fu Deyu 
Published: January 2023

Objective: To evaluate the efficacy of ginseng-containing traditional Chinese medicine (TCM) for acute decompensated heart failure (ADHF).Methods: Seven databases were included from establishment until 10 July 2022. Pooled data were analyzed with random-effects model. The risk of bias was measured by the risk of bias tool for randomized trials (RoB 2). Modified Jadad scale score was used to assess the quality of including studies. The meta-analysis was performed with RevMan 5.3. Trial sequential analysis was assessed to avoid type I errors. We have registered our protocol in PROSPERO (CRD42021267742).Results: Twenty-eight articles were included. The results demonstrated that compared with conventional western therapy (WT), ginseng-containing TCM combined with WT further improved clinical efficacy (RR: 1.25, 95% CI: 1.20–1.29, p &lt; 0.00001, I2 = 8%), left ventricular ejection fraction (LVEF) (MD: 5.80, 95% CI: 4.86–6.74, p &lt; 0.00001, I2 = 89%), stroke volume (MD: 13.80, 95% CI: 12.66–14.95, p &lt; 0.00001, I2 = 93%), 6-min walk test (MD: 53.03, 95% CI: 20.76–85.29, p = 0.001, I2 = 97%), decreased 6-month rehospitalization (RR: 0.44, 95% CI: 0.18–1.11, p = 0.08, I2 = 0%), brain natriuretic peptide (MD: 188.12, 95% CI: 248.13 to -128.11, p &lt; 0.00001, I2 = 94%), N-terminal pro-B-type natriuretic peptide (MD = -503.29; 95% CI: 753.18 to -253.40, p &lt; 0.0001, I2 = 89%) and Minnesota living heart failure questionnaire scores (MD: 9.68, 95% CI: 13.67 to -5.70, p &lt; 0.00001, I2 = 83%). The ROB2 assessment and modified Jaded scores showed most studies included were with some concerns.Conclusion: Compared with WT alone, ginseng-containing TCM is a possible way to benefit ADHF patients. However, limited by the quality of including trials, more high-quality studies are needed to provide reliable evidence.
The mechanism of oxymatrine on atopic dermatitis in mice based on SOCS1/JAK-STAT3 pathway
Authors: Han Xianwei , Ma Tianming , Wang Qiang , Jin Chunlin , Han Yusheng , Liu Guijun , Li Hao 
Published: January 2023

Based on the suppressor of cytokine signaling 1 (SOCS1)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway, the mechanism of oxymatrine in the treatment of atopic dermatitis (AD) was preliminarily explored in this study. C57BL/6 mice were induced to establish AD model by smearing carbotriol (MC903) on their back. The AD mice were randomly divided into model group, oxymatrine groups with three dosages (25, 50 and 100 mg/kg), (n = 10). Oxymatrine groups were intragastric administered once daily for 14 days. The same volume of saline was given in the normal control group and model group once daily for 14 days. Subsequently, HE staining was used to observe the pathological changes of skin tissue, ELISA was used to detect the levels of serum inflammatory factors including interleukin-4, 6 and 17 (IL-4, IL-6, and IL-17), tumor necrosis factor-α (TNF-α) and immunoglobulin E (IgE). Immunohistochemistry was used to detect the expression of suppressor of cytokine signaling 1 and CD3 in skin tissue, and Western blotting was used to detect the proteins in suppressor of cytokine signaling 1/JAK-STAT3 pathway. Compared with the normal control group, the pathological damage of mice in the model group, such as skin hyperplasia, edema, congestion and inflammatory infiltration, aggravated increased significantly. And the expression of serum inflammatory factors, CD3 positive expression and JAK-STAT3 pathway protein in the model group were increased (p &lt; .05), and the expression of suppressor of cytokine signaling 1 protein (p &lt; .05) was decreased. Compared with the model group, the above pathological damage of the mice was reduced, and the serum inflammatory factors, JAK-STAT3 pathway protein, and CD3 positive expression were decreased as a dose-dependant manner (p &lt; .05), and the expression of suppressor of cytokine signaling 1 protein was increased as a dose-dependent manner (p &lt; .05). Oxymatrine can improve the skin inflammation symptoms of AD mice by up regulating the expression of suppressor of cytokine signaling 1, inhibiting the activation of JAK-STAT3 pathway and blocking the activation of T lymphocytes.
Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair
Authors: Sun Xiaoning , Li Siting , He Yuan , Liu Yuxi , Ma Tianxiang , Zeng Rong , Liu Zhili , Chen Yu , Zheng Yuehong , Liu Xiao 
Published: January 2023

Introduction: Chronic heart disease (CHD) is a common comorbidity of patients receiving endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA). The explicit relationship between ventricular systolic function and EVAR complication of thrombotic events is unknown.Methods: In this study, we proposed a three-dimensional numerical model coupled with the lumped-elements heart model, which is capable of simulating thrombus formation in diverse systolic functions. The relation of cardiac functions and the predicted risk of thrombus formation in the aorta and/or endograft of 4 patients who underwent EVAR was investigated. Relative risks for thrombus formation were identified using machine-learning algorithms.Results: The computational results demonstrate that thrombus tended to form on the interior side of the aorta arch and iliac branches, and cardiac function can affect blood flow field and affect thrombus formation, which is consistent with the four patients' post-operative imaging follow-up. We also found that RRT, OSI, TAWSS in thrombosis area are lower than whole average. In addition, we found that the thrombus formation has negative correlations with the maximum ventricular contractile force (r = −.281 ± .101) and positive correlations with the minimum ventricular contractile force (r = .238 ± .074), whereas the effect of heart rate (r = −.015 ± .121) on thrombus formation is not significant.Conclusion: In conclusion, changes in ventricular systolic function may alter the risk of thrombotic events after EVAR repair, which could provide insight into the selection of adjuvant therapy strategies for AAA patients with CHD.
Research on the influence mechanism of privacy invasion experiences with privacy protection intentions in social media contexts: Regulatory focus as the moderator
Authors: Chen Subai , Gu Chenyu , Wei Juan , Lv Mingjie 
Published: January 2023

IntroductionIn recent years, there have been numerous online privacy violation incidents caused by the leakage of personal information of social media users, yet there seems to be a tendency for users to burn out when it comes to privacy protection, which leads to more privacy invasions and forms a vicious circle. Few studies have examined the impact of social media users' privacy invasion experiences on their privacy protection intention. Protection motivation theory has often been applied to privacy protection research. However, it has been suggested that the theory could be improved by introducing individual emotional factors, and empirical research in this area is lacking.MethodsTo fill these gaps, the current study constructs a moderated chain mediation model based on protection motivation theory and regulatory focus theory, and introduces privacy fatigue as an emotional variable.Results and discussionAn analysis of a sample of 4800 from China finds that: (1) Social media users' previous privacy invasion experiences can increase their privacy protection intention. This process is mediated by response costs and privacy fatigue. (2) Privacy fatigue plays a masking effect, i.e., increased privacy invasion experiences and response costs will raise individuals' privacy fatigue, and the feeling of privacy fatigue significantly reduces individuals' willingness to protect their privacy. (3) Promotion-focus individuals are less likely to experience privacy fatigue than those with prevention-focus. In summary, this trend of “lie flat” on social media users' privacy protection is caused by the key factor of “privacy fatigue”, and the psychological trait of regulatory focus can be used to interfere with the development of privacy fatigue. This study extends the scope of research on privacy protection and regulatory focus theory, refines the theory of protection motivation, and expands the empirical study of privacy fatigue; the findings also inform the practical governance of social network privacy.
Father presence and resilience of Chinese adolescents in middle school: Psychological security and learning failure as mediators
Authors: Wei Xueyan , Zhuang Miao , Xue Linfang 
Published: January 2023

IntroductionThis study aimed to explore the association between father presence and adolescent resilience and the mediating role of psychological security and learning failure. Examining the mediating effects of learning failure and the chain mediating effect of psychological security and learning failure elucidated the link between father presence and adolescent resilience.MethodsThe present study conducted a questionnaire survey among Chinese middle school students on father presence, resilience, psychological security, and learning failure. The survey collected 626 valid responses.ResultsThe findings showed that father presence, psychological security, learning failure, and resilience were significantly positively correlated; father presence had a direct effect on adolescent resilience, and psychological security and learning failure both mediated the relationship between father presence and adolescent resilience; psychological security and learning failure served as chain mediators between father presence and adolescent resilience.DiscussionThis study aimed to provide theoretical and practical insights into the field of family education.
Multi-domain computerized cognitive training for children with intellectual developmental disorder: A randomized controlled trial
Authors: Wu Jingsong , Peng Juan , Li Zhaoying , Deng Haiyin , Huang Zhenming , He Youze , Tu Jingnan , Cao Lei , Huang Jia 
Published: January 2023

PurposeTo verify the effects of multi-domain computerized cognitive training on intellectual function and adaptive functioning in children with intellectual developmental disorder (IDD).MethodsChildren with IDD were randomized to a multi-domain computerized cognitive training (CCT) group (n = 30) and control group (n = 30). Both groups received a 5-week training program. Intellectual function was assessed by Chinese-Wechsler Young Children scale (C-WYCSI) and adaptive functioning was assessed by the Chinese Vineland Adaptive Behavior Rating Scale (VABS-C), which were used at baseline, post-training, and 3-month follow-up.ResultsThere were significant differences for intellectual function and adaptive functioning between the two groups. The CCT group showed significant improvements in total full-scale intelligence quotient (FSIQ) score the Wechsler Intelligence Scale (F[60] = 31.97, p &lt; 0.01) and its subdomain VIQ score (F[60] = 33.83, p &lt; 0.01). For adaptive functioning, CCT had a better adaptive developmental quotient (ADQ) score (F[60] = 28.05, p &lt; 0.01), and subdomain communication (F[60] = 10.86, p &lt; 0.01) and socialization scores (F[60] = 4.35, p &lt; 0.015). Moreover, there was a positive correlation between FSIQ changes and ADQ changes in the CCT group (rs = 0.74, p &lt; 0.01). A greater increase in VIQ score was associated with a greater increase in adaptive functioning (bootstrapping CI: [0.16, 3.30]) in the CCT group.ConclusionMulti-domain CCT improves the intellectual function and adaptive functioning of children with IDD.
Revalidation of preservice physical education teacher’s teacher identity scale in Chinese physical education student teachers
Authors: Yang Anlu , Wang Yongshun , Yao Lei , Hamilton Xiaofen D. 
Published: January 2023

IntroductionTeacher identity (TI) is a crucial aspect to pre-service physical education teachers (PPETs) to becoming high quality teachers and plays an important role in their career choice. Thus, a deep understanding of their TI may help improve the quality of future PE teachers. This study aimed to provide further evidence of reliability and validity for Preservice Physical Education Teacher’s Teacher Identity Scale (PPET-TI scale).MethodsThe study went through a three-stage development process: (a) examining the content validity of original scale; (b) data collection using a sample of student teachers in physical education; (c) re-test the reliability and validity of the scale developed by Zhang.Results and DiscussionAfter having re-examined the content validity, the domain of affects was deleted. The modified scale then consisted of the three domains (i.e., value and expectation, perceived confidence of teaching PE, and professional growth). A total of 944 physical education student teachers in China participated in the study. Confirmatory factor analysis (CFA) was employed to investigate the construct validity, the results suggested the data did not fit the original model. After the unfitted item was excluded. All CFA fit indices were within the acceptable range. Reliability of the scale was then examined by calculating G-C alphas. The alpha values were within the acceptable range. The modified model was reliable and valid. The revalidation of the scale provided more us with a scale that could produce reliable and valid score measuring PPETs’ TI.
Cooperative behavior in the workplace: Empirical evidence from the agent-deed-consequences model of moral judgment
Authors: Sattler Sebastian , Dubljević Veljko , Racine Eric 
Published: January 2023

IntroductionMoral judgment is of critical importance in the work context because of its implicit or explicit omnipresence in a wide range of work-place practices. The moral aspects of actual behaviors, intentions, and consequences represent areas of deep preoccupation, as exemplified in current corporate social responsibility programs, yet there remain ongoing debates on the best understanding of how such aspects of morality (behaviors, intentions, and consequences) interact. The ADC Model of moral judgment integrates the theoretical insights of three major moral theories (virtue ethics, deontology, and consequentialism) into a single model, which explains how moral judgment occurs in parallel evaluation processes of three different components: the character of a person (Agent-component); their actions (Deed-component); and the consequences brought about in the situation (Consequences-component). The model offers the possibility of overcoming difficulties encountered by single or dual-component theories.MethodsWe designed a 2 × 2 × 2-between-subjects design vignette experiment with a Germany-wide sample of employed respondents (N = 1,349) to test this model.ResultsResults showed that the Deed-component affects willingness to cooperate in the work context, which is mediated via moral judgments. These effects also varied depending on the levels of the Agent- and Consequences-component.DiscussionThereby, the results exemplify the usefulness of the ADC Model in the work context by showing how the distinct components of morality affect moral judgment.
Exploring the influence of cultural participation on the subjective well-being of victims in Mexico
Authors: Reyes-Martínez Javier , Martínez-Martínez Oscar A. , Lombe Margaret , Piñeros-Leaño María 
Published: January 2023

IntroductionConsidering the increasing incidence of crime in Mexico, it is necessary to understand the strategies that individuals utilize in response to victimization and the effects of this on their subjective well-being.MethodsA generalized structural equation modeling (GSEM) analysis with data from the 2012 Self-reported Well-Being Survey (BIARE,n = 10,654); dependent variables: subjective well-being (i.e., cognitive well-being and affective balance); independent variables: self-reported victimization (i.e., by domestic violence, community violence, and structural violence) and cultural participation (i.e., cultural attendance, engagement, and consumption).ResultsResults show an overall positive and statistical influence of the cultural participation activities on the subjective well-being of victims of community and structural violence (but not of domestic violence), because, for those who reported higher levels of cultural participation, the probability of better subjective well-being were higher.ConclusionsVictims potentially coped and adapted to stressful and traumatic situations (i.e., experiences of victimization) via cultural participation activities. However, there are distinctive effects according to different forms of violence, which may be accounted for in formulating public policies related to victims. This has implications for scholars, policymakers, and practitioners in improving the general quality of life of victims and the general population.
Photobiomodulation improves frontal lobe cognitive functions and mental health of older adults with non-amnestic mild cognitive impairment: Case studies
Authors: Cheung Mei-Chun , Lee Tsz-Lok , Sze Sophia L. , Chan Agnes S. 
Published: January 2023

IntroductionThis study investigated the effects of transcranial photobiomodulation (tPBM) on improving the frontal lobe cognitive functions and mental health of older adults.MethodsThree older adults with mild cognitive impairment (MCI) of the non-amnestic type received 18-session tPBM stimulation for 9 weeks and were assessed with neuropsychological tests of memory and executive functions and standardized questionnaires on depressive and anxiety symptoms, global cognitive functions, and daily functioning abilities before and after tPBM stimulation.ResultsAt baseline, their intrusion and/or perseveration errors in a verbal memory test and a fluency test, as measures of the frontal lobe cognitive functions, were in the borderline to severely impaired range at baseline. After tPBM stimulation, the three older adults showed various levels of improvement in their frontal lobe cognitive functions. One older adult’s intrusion and perseveration errors improved from the &lt;1st–2nd percentile (moderately to severely impaired range) to the 41st–69th percentile (average range), another older adult’s intrusion errors improved from the 11th percentile to the 83rd percentile, and the third older adult’s intrusion errors improved from the 5th percentile to the 56th percentile. Moreover, improvements in their anxiety and/or depressive symptoms were also observed. One older adult’s depressive and anxiety symptoms improved from the severe range at baseline to the mild range after the intervention. The other two older adults’ depressive symptoms improved from the mild range at baseline to the normal range after the intervention.DiscussionThese findings provide preliminary support for the potential of tPBM to improve the frontal lobe cognitive functions and mental health of older adults with MCI. Given the small sample size of only three older adults and the absence of a placebo control group, larger randomized controlled studies are needed to confirm its potential.
Prevalence of suicidal behavior in a northeastern Mexican border population during the COVID-19 pandemic
Authors: Villarreal Sotelo Karla , Peña Cárdenas Fabiola , Zamorano González Benito , Vargas Orozco Cynthia Marisol , Hernández Rodríguez Ignacio , Landero Pérez Carolina 
Published: January 2023

IntroductionBefore the pandemic, suicide was already considered a global public health problem. The outbreak of COVID-19, a coronavirus-related infectious disease, began to impact people's physical and mental health. The factors that either contribute to or mitigate this risk need to be better understood, and this can only be accomplished through research. Therefore, this study aimed to study the prevalence of suicidal ideation and behavior in Tamaulipas, Mexico, during the COVID-19 pandemic.MethodsA quantitative, descriptive, and cross-sectional study was conducted. The sample consisted of 659 participants, of whom 194 (29.5%) were men and 465 (70.5%) participants were oldwomen, ranging in age between 16 and 68 years (M = 22.56, SD = 7.26). An adapted version of the Spanish version of the Columbia Suicidal Severity Rating Scale was used to assess the seriousness of suicidal ideation and behavior.ResultsThe higher rates of suicidal indicators were suicidal ideation with “wish to dead” (39.9%), while the lower was suicidal ideation with a specific plan (8.2%). A total of 18.2% of participants reported “suicidal attempts before COVID-19,” of whom 40% reported “suicidal attempts in the last 3 months.” Suicidal behavior rates were lower: 13.7% of participants reported “non-specific preparatory behavior” and 13.3% reported “actual suicide attempts.” Women were more likely than men to exhibit almost all indicators of suicidal ideation and behavior (OR = 1.63–2.54; 95% CI = 1.11–2.41, 1.76–3.68), as well as confinement (OR = 2.60; 95% CI = 1.73–3.91). Confinement for more than 40 days (OR = 0.55–0.66; 95% CI = 0.40–0.75, 0.47–0.93) and knowing a person infected with COVID-19 (OR = 1.57–2.01; 95% CI = 1.02–2.42, 1.20–3.34) were associated with a higher risk of exhibiting several suicidal indicators and having previously attempted suicide.ConclusionBeing a woman, knowing a person infected with COVID-19, and being confined, especially for longer than 40 days, are all risk factors for suicidal ideation. Therefore, intervention programs are needed to reduce the suicide risk prevalence, especially these days because of the influence of the pandemic, and should be primarily focused on those who present the risk factors associated with suicidal behavior identified in this study.