bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Grade Appendiceal Mucinous Neoplasm Presenting as Intussusception In an Elderly Female-A Case Report
Authors: SKVSK Manjari , Prasanna Mark Ruth , Venkatachalam T Satya Prakash 
Published: September 2023

Introduction: Appendiceal mucinous neoplasms (AMNs) are rare and account for 1% of gastrointestinal neoplasms and the diagnosis is mostly incidental. In spite of advances in the understanding of AMNs and their association with peritoneal disease, AMNs are still confusing entities in respect to their diagnosis and treatment alike.
Case Report: We report a case of a 51year old female who presented with abdominal pain and vomiting and was diagnosed as ileo-colic intussusception on ultrasonography and CECT abdomen. Histopathological examination of right hemicolectomy specimen revealed a high grade appendicular mucinous neoplasm with low grade areas. The peri-appendiceal mucin deposition forming a mass in the cecum at the base of appendix was the lead point for intussusception in this case. No features of pseudomyxoma peritonei was seen in this case. This patient is well after 18 months of follow up period.
Conclusion: Appendiceal mucinous neoplasms are rare and diagnosis is often difficult as presentation is mostly non-specific. Hence, awareness and further classification of these tumours is essential for diagnosis, determining the risk of recurrence and malignancy and also prognostication.
A case report Case Report of Idiopathic Pulmonary Haemosiderosis in a Child with recurrent chest infections
Authors: Patwardhan Leena Milind , Sharma Sunita , Khawale Manisha 
Published: September 2023

Idiopathic Pulmonary Hemosiderosis (IPH) is a rare condition, usually occurring in children and teenagers. The classic presentation is of haemoptysis, iron deficiency anaemia and diffuse pulmonary infiltrates. We report a case of IPH in an 8 year old boy, who presented with recurrent episodes of fever, cough and respiratory infections without any trigger since childhood.
Prevalence Of Diabetes And Association Of Fasting And Postprandial Glucose With Hba1c, 6-Year Study In Reference Laboratory
Authors: Gohil Sanjay , Singh Preeti , Kambli Megha , Haryan Reshma , Jatale Raj , Dixit Rakhi Bajpai , Chadha Kirti 
Published: September 2023

Background
Prevalence of diabetes is estimated in the Indian population using hemoglobin A1c (HbA1c) data collected over the period of 6 years, in the Metropolis Reference Laboratory Mumbai. HbA1c values with gender and age structure was correlated during fasting and postprandial glucose for the non-diabetic, pre-diabetic, and diabetic populations in terms of frequency and percentile.
Method
Retrospective analysis of HbA1c data obtained in a referral laboratory based in Mumbai over a span of 6 years from 2015 to 2020. A total of 2,94,264 cases were divided in six age groups i.e. 15-20Y, 21-30Y, 31-40, 41-50, 51-60, and >60Y. High-performance liquid chromatographic separation and quantification of HbA1c in blood with gender and age were done. HbA1c values were also correlated with glucose fasting and postprandial in the studied population.
Results
Prevalence of diabetes (HbA1C >6.5) was 57.60% in the studied population. The incidence and prevalence of HbA1c in the diabetic range were highest in the age group of >60 years. Males showed a higher prevalence of diabetes than females, while females are found to be more pre-diabetic. A significant (p>0.001) positive linear correlation was found between HbA1c with fasting and postprandial glucose, respectively.
Conclusion
The age group of >60Y showed a maximum diabetic prevalence. Gender disparity was recorded more in males than females having higher HbA1c. The sensitivity of HbA1c is comparable with fasting and postprandial glucose. However, HbA1c cannot replace plasma glucose estimation and could be used in conjunction with fasting and postprandial glucose for proper diagnosis and disease management.
Lake water quality assessment using spatial interpolation and the development of the WQI on an educational campus, Assam, India
Authors: Talukdar Pritam , Mokenepally Tarun , Kulkarni Vihangraj Vijaykumar 
Published: September 2023

Abstract

Monitoring water quality metrics is essential for managing water quality and safeguarding aquatic life. The NIT Silchar Lake has been a place for many aquatic plants and migratory birds. The lake water is typically used on campus for horticultureal purposes. However, the peasants living close to campus use the lake water for drinking during situations like floods or famine. At four separate locations of the lake, the samples were collected for evaluation of seven water quality indicators. Temperature between 22.4 and 30.5 °C and dissolved oxygen concentrations between 8 and 13 mg/l were found, which were optimal conditions for aquatic life. The water quality index (WQI), which gives an overall evaluation of the state of the water quality, was created from the measured values (six parameters). The lake regions that ranged from good to excellent were identified using ‘weighted arithmetic water quality index’ (WAWQI) technique. Further we have compared the WAWQI with another method. A comparative analysis has been done by developing simple codes with the help of python programming language. The inverse distance weighted (IDW) interpolation in GIS was applied for spatial distribution of water quality parameters and WQI.
The Potential Therapeutic Applications of CRISPR/Cas9 in Colorectal Cancer
Authors: Sahranavard Toktam , Mehrabadi Shima , Pourali Ghazaleh , Maftooh Mina , Akbarzade Hamed , Hassanian Seyed Mahdi , Mobarhan Majid Ghayour , Ferns Gordon A. , Khazaei Majid , Avan Amir 
Published: September 2023

:
The application of the CRISPR-associated nuclease 9 (Cas9) system in tumor
studies has led to the discovery of several new treatment strategies for colorectal cancer
(CRC), including the recognition of novel target genes, the construction of animal mass
models, and the identification of genes related to chemotherapy resistance. CRISPR/Cas9
can be applied to genome therapy for CRC, particularly regarding molecular-targeted
medicines and suppressors. This review summarizes some aspects of using CRISPR/-
Cas9 in treating CRC. Further in-depth and systematic research is required to fully realize
the potential of CRISPR/Cas9 in CRC treatment and integrate it into clinical practice.
Application of Color Doppler Ultrasound to Evaluate and Analyze the Risk
Factors of Residual Stenosis after Vertebral Artery Origin Stenting
Authors: Han Yue , Mo Xi-ping , Ge Xin-yue , Huang Jian-yuan 
Published: September 2023

Background:
Vertebral artery origin stenting (VAOS) is the mainstream method for the treatment of vertebral artery stenosis (VAS). However, there are few studies on the risk factors analysis for residual stenosis after VAOS.

Purpose:
This study aimed to apply color Doppler ultrasound (CDU) to evaluate and analyze the risk factors of residual stenosis after VAOS.

Methods:
About 178 patients with VAOS were included from 2017 to 2019 in Liuzhou worker's hospital and divided into the residual stenosis group (n = 38) and the no-residual stenosis group (n = 140). The clinical data and hemodynamics alteration before and after VAOS were collected. The univariate and multivariate logistic regression analysis was used to analyze the risk factors of residual stenosis.

Results:
Compared with the no-residual stenosis group, the proportion of hypertension, the bending of the initial segment, and the residual stenosis length > 10 mm in the residual stenosis group were significantly higher, while the original internal diameter was significantly smaller (P < 0.05). The multivariate logistic regression analysis showed that the bending of initial segment (OR = 2.41, 95% CI: 1.32-5.45, P = 0.033), the original internal diameter (OR = 2.29, 95% CI: 1.13-5.66, P = 0.001), and the residual stenosis length > 10 mm were the risk factors of residual stenosis (OR = 2.78, 95% CI: 1.82-5.85, P = 0.044).

Conclusion:
The bending of initial segment, the original internal diameter, and the residual stenosis length > 10 mm were the risk factors of residual stenosis after VAOS.
Study on Measurement Method of Three-dimensional Position of
Unlabeled Microspheres under Bright Background
Authors: Xu Ke , Wang Bingge 
Published: September 2023

Abstract:
Using computer vision technology to obtain the position and trajectory data of particle probe microspheres from microscope images has significance and value in the molecular
field. However, most of the existing microsphere measurement methods are based on transmission, which can only be measured under transparent samples and substrates and are not suitable
for the application scenario of living cell measurement. In this paper, a method based on reflectivity imaging is proposed to measure the three-dimensional position of the dark microspheres in
the bright field. Based on the outermost ring radius method, the relationship between the inner
ring radius of the microsphere spot and the out-of-focus distance was explored to measure the
coordinates in the Z direction. Cardiomyocytes were combined with 10um size silica microspheres. Experiments show that in a bright field with a high perturbation environment, it can
achieve high precision measurement of dark microspheres and achieve three-dimensional position measurement with an accuracy of 50nm in XY direction and 100nm in Z direction.
Current Strategies for the Management of Psoriasis with Potential
Pharmacological Pathways using Herbals and Immuno-biologicals
Authors: Sharma Kiran , Kumar Sumit 
Published: September 2023

Background:
Psoriasis is an acute to chronic multifunctional inflammatory skin disorder mediated through T-cell activation, dendritic cell intervention, local vascular variations, atypical keratinocyte proliferation, and neutrophil activation, leading to a skin disorder with no permanent cure.

Objective:
This review aims to find a potent, secure, and dependable medication, with a more scientific examination of herbal resources and recent targeted immunobiological therapies.

Methods:
Reports evaluating the effectiveness of biologics & herbal remedies for the topical therapy of psoriasis against control therapies were taken into consideration (placebo or active therapy). The work examined cellular circuits involved in inflammation with its immunogenetic mechanism behind various options available for treating psoriasis in addition to the role of agents inducing psoriasis.

Results:
The extent of psoriasis can range from small, localized spots to total body coverage, and it can happen at any stage of life. Several theories exist for clarification however, the exact cause of psoriasis is not entirely understood. Researchers have discovered genetic loci linkages, environmental changes, drug induction, lifestyle conditions, some infections, etc. resulting in this disorder. There are numerous known conventional medical treatments for psoriasis, ranging from topical and systemic medicines to phototherapy or combinations of both with recent immunobiological treatment. However, the majority of these treatments are ineffective and have a variety of side effects that limit their long-term usage, such as cutaneous atrophy, tissue toxicity, mutagenicity, and immunosuppression.

Conclusion:
Herbal extracts or isolated compounds can be considered as a substitute for conventional psoriasis treatment. Unfortunately, many investigations often provide a small amount of facts about the safety and effectiveness of topically applied herbal remedies for the treatment of psoriasis. Thus, further factual evidences and validations are needed to promote herbal options, which must be supported by rigorous animal studies or clinical trials using standardised materials and compositions.
An 18F-MD-PSMA (Multi-dentate PMSA Imaging Agent) PET/CT in Prostate Cancer Relapse: Results of a Retrospective Trial
Authors: Fu Hongliang , Liang Sheng , Xu Miaomiao , Guo Jun , Liu Qiang , Kang Jian , Zhang Linlin , Liu Zihao , Ding Lin , Ma Yufei , Yang Bin , Yao Xudong , Qi Jun , Wang Hui , Cai Yongquan 
Published: September 2023

Purpose:
This study aimed to evaluate the performance of 18F-MD-PSMA PET/CT in
patients previously treated for prostate cancer by either surgery or therapy, but later relapsed biochemically.

Methods:
This retrospective study enrolled 213 patients in sequence previously treated for prostate
cancer by either surgery or therapy, but later PSA relapsed. A total of 191 of these 213 patients
were included in this analysis. All patients were biochemically relapsed after radical prostatectomy
or therapy, had 18F-MD-PSMA PET/CT scan within 1 week, and were off hormonal
therapy at the time of the scans. The new tracer was compared directly with 11C-choline in sensitivity.

Results:
In 3 patients, a side-by-side comparison between 18F-MD-PSMA and 11C-choline was
performed, and it was found that the former was about 3 times more sensitive than the latter. The
analysis of PET imaging using 18F-MD-PSMA in 191 relapsed patients showed that less than
10% of patients showed the disease limited in the prostate. Among the remote lesions, the number
in decreasing order was bone, followed by lymph nodes and other organs. The maximal SUV in
lesions in each patient followed an exponential decay, with SUV inclined to the lower end. The
Gleason score measured at the diagnosis showed no correlation with the average number of lesions
in each patient, the average maximal SUV values among this cohort of patients, and the PSA values
measured at the time of PET imaging. The number of lesions observed in each patient has no
correlation with the PSA value measured at the time of PET imaging. When PSA value was measured
as an independent biomarker at the time of PET imaging, the positivity of PET imaging using
18F-MD-PSMA increased along with an increase in PSA value, but with exceptions where PSMA
expression was low or negative. From the PET imaging of this radioligand, the majority of patients
showed oligo-metastasis, favoring using local therapy to manage the disease.

Conclusion:
An 18F-MD-PSMA as a radioligand was found to be superior to 11C-choline in the
setting of patients with biochemical relapse after previous treatment. Its PET imaging results
matched those of established PSMA radioligands, but its chemical structure was found to have
added features to conjugate with other functional molecules, such as those with therapeutic properties.
This radioligand lays the foundation for our further work.
A Descriptive Analysis of the Nutraceutical Constituents, Extraction
Techniques, and Possible Health Benefits of Tamarind
Authors: Wal Pranay , Debnath Biplab , Sarkar Dhrubajyoti , Verma Neha , Rathore Shruti , Wal Ankita 
Published: September 2023

Background:
Tamarind is a multifunctional tree, with nearly every portion having significant
nutritional or therapeutic use. The fruit, which produces acidic pulp, is the most valuable
and often utilized portion.

Objective:
The aim of this paper is to discuss the distribution, habitat, chemical constituents and
extraction techniques of tamarind.

Methods:
This study reviews the chemical constituents, health benefits and extraction techniques of
tamarind. Databases such as PubMed, Scopus, Science Direct, and Google Scholar were used to
search articles from 1990 to 2022. The key search terms included tamarind, phytoconstituents extraction
and anti-nutritional factor. Research studies also included similar plant parts extracted
from similar solvents which were considered in this review.

Results:
According to our observations, Tamarindus indica is a crucial plant with significant pharmacological
properties. It is extensively used as a conventional medicine to treat a variety of disorders;
however, its active ingredients require further investigation for future drug development and
pharmacological activity. Tamarind contains a diverse range of bioactive compounds, including
polyphenols, flavonoids, alkaloids, vitamins, and minerals, which have been associated with various
health-promoting properties. The study examines different extraction methods used to isolate
tamarind's bioactive constituents, such as solvent extraction, supercritical fluid extraction (SFE),
and microwave-assisted extraction (MAE). Furthermore, the research highlights the potential
health benefits of tamarind, including antioxidant activity, anti-inflammatory effects, gastrointestinal
support, cardiovascular benefits, and antimicrobial properties.

Discussion:
Tamarind includes citric acid, linoleic acid, volatile oils, vitamin C, potassium, Camp
sterol, -amyrin, Tannins, saponins, and glycosides as a result of this. It has several pharmacological
properties such as reducing swelling, preventing oxidation, hypolipidemic, weight loss, antibacterial,
hepatoprotective, anthelmintic, and painkiller properties. These properties will assist to generate
interest in Tamarind and develop novel preparations with more medicinal and commercial potential.
The findings indicate that tamarind holds significant promise as a natural resource for developing
functional foods, nutraceuticals, and pharmaceuticals with potential positive impacts on human
health.
Diabetes Life Expectancy Prediction Model Inputs and Results From Patient Surveys Compared With Electronic Health Record Abstraction: Survey Study
Authors: Bernstein Sean , Gilson Sarah , Zhu Mengqi , Nathan Aviva G , Cui Michael , Press Valerie G , Shah Sachin , Zarei Parmida , Laiteerapong Neda , Huang Elbert S 
Published: September 2023

Abstract

Background
Prediction models are being increasingly used in clinical practice, with some requiring patient-reported outcomes (PROs). The optimal approach to collecting the needed inputs is unknown.

Objective
Our objective was to compare mortality prediction model inputs and scores based on electronic health record (EHR) abstraction versus patient survey.

Methods
Older patients aged ≥65 years with type 2 diabetes at an urban primary care practice in Chicago were recruited to participate in a care management trial. All participants completed a survey via an electronic portal that included items on the presence of comorbid conditions and functional status, which are needed to complete a mortality prediction model. We compared the individual data inputs and the overall model performance based on the data gathered from the survey compared to the chart review.

Results
For individual data inputs, we found the largest differences in questions regarding functional status such as pushing/pulling, where 41.4% (31/75) of participants reported difficulties that were not captured in the chart with smaller differences for comorbid conditions. For the overall mortality score, we saw nonsignificant differences (P=.82) when comparing survey and chart-abstracted data. When allocating participants to life expectancy subgroups (<5 years, 5-10 years, >10 years), differences in survey and chart review data resulted in 20% having different subgroup assignments and, therefore, discordant glucose control recommendations.

Conclusions
In this small exploratory study, we found that, despite differences in data inputs regarding functional status, the overall performance of a mortality prediction model was similar when using survey and chart-abstracted data. Larger studies comparing patient survey and chart data are needed to assess whether these findings are reproduceable and clinically important.
Content Quality of YouTube Videos About Metastatic Breast Cancer in Young Women: Systematic Assessment
Authors: Morena Nina , Ahisar Yitzchok , Wang Xena , Nguyen Diana , Rentschler Carrie A , Meguerditchian Ari N 
Published: September 2023

Background
Young women with metastatic breast cancer (MBC) are part of a digitally connected generation yet are underserved in terms of information needs. YouTube is widely used to find and identify health information. The accessibility of health-related content on social media together with the rare and marginalized experiences of young women with MBC and the digital media practices of younger generations imply a considerable likelihood that young women with MBC will seek information and community on the internet.

Objective
This study aims to assess the content quality of MBC YouTube videos and to identify themes in the experiences of young women with MBC based on YouTube videos.

Methods
A systematic assessment of MBC YouTube videos using the search term “metastatic breast cancer young” was conducted in August 2021. The search was performed in an incognito browser and with no associated YouTube or Google account. Search results were placed in order from most to least views. Title, date uploaded, length, poster identity, number of likes, and number of comments were collected. Understandability and actionability were assessed using the Patient Education Materials Assessment Tool (PEMAT); information reliability and quality were assessed with DISCERN. Themes, sponsorships, and health care professionals’ and patients’ narratives were reported.

Results
A total of 101 videos were identified. Of these, 78.2% (n=79) included sponsorships. The mean PEMAT scores were 78.8% (SD 15.3%) and 43.1% (SD 45.2%) for understandability and actionability, respectively. The mean DISCERN score was 2.44 (SD 0.7) out of 5. Identified themes included treatment (n=67, 66.3%), family relationship (n=46, 45.5%), and motherhood (n=38, 37.6%).

Conclusions
YouTube videos about young women with MBC are highly understandable but demonstrate moderate rates of actionability, with low reliability and quality scores. Many have a commercial bias. While web-based materials have limitations, their potential to provide patient support is not fully developed. By acknowledging their patients’ media habits, health care professionals can further develop a trusting bond with their patients, provide a space for open and honest discussions of web-based materials, and avoid any potential instances of confusion caused by misleading, inaccurate, or false web-based materials.
Group Cognitive Behavior Therapy (Cbt) Terhadap Penurunan Tingkat Kecemasan Pada Korban Perilaku Kekerasan (Bullying) Di Sekolah Dasar
Authors: Damaiyanti Siska , Putri Marizki 
Published: September 2023

Background: Based on research data from PISA 2018, it was found that 4 out of 10 students in Indonesia have been victims of bullying. One of the impacts of violent behavior on children (bullying) is anxiety. Objective:The purpose of this study was to address anxiety or the risk of psychosocial disorders by using group cognitive behavior therapy (CBT)in Solok CityMethod: This was quasi experimental study with pre-post test group.The sample in this study were elementary school who had experienced bullying. To measure the level of anxiety in victims of violent behavior (bullying) using a measuring tool or instrument known as the Hamilton Rating Scale For Anxiety (HRS - A)Results and Discussion: the results showed that there was a decrease in anxiety among victims of bullying behavior after Cognitive Behavior Therapy (CBT) group therapy (p = 0.031).Conclusion: CBT can be applied as a method of reducing anxiety that can be given to victims of bullying