bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Complete Recovery in a Hypereosinophilic Dermatitis Patient with Dupilumab
Authors: Jiang Xiaoyun , Ye Jun , Wu Xia , Zhu Jiang , Chen Siji , Cheng Hao 
Published: January 2023

Abstract
Hypereosinophilic dermatitis (HED) is a subtype of hypereosinophilic syndrome (HES). Glucocorticoids are preferred for treatment but could carry a number of significant side effects. Symptoms of HED may recur after systemic glucocorticoid tapering. As a humanized monoclonal antibody targeting interleukin-4 receptor (IL-4Rα), dupilumab might be an efficacious adjuvant therapy for HED. We report a young male who suffered from erythematous papules with pruritus for over five years. He was diagnosed with HED by the presence of skin tissue with bone marrow and peripheral blood eosinophilia. Once reduction the dosage of glucocorticoid, his skin lesions relapsed. Using dupilumab, his condition significantly improved, and the glucocorticoid amount decreased successfully. In conclusion, we reported a new application of dupilumab in HED patients.
The situation and some factors related to the health of children with autism spectrum disorder in Ninh Kieu District early childhood schools, Cantho City in 2020–2021
Authors: Duong Lam Phuc , Ho Trang Thu Thi 
Published: January 2023

Abstract
Autism spectrum disorder is on the rise. In a study by the National Children's Hospital, within 7 years, the number of autistic children coming to the clinic increased by 50 times, and the number of visits for treatment increased by 33 times. with a cross-sectional descriptive study design and analysis of 304 children who have been diagnosed with autism spectrum disorder and are receiving intervention in preschools and special education centers in Ninh Kieu District, Ho Chi Minh City. Can Tho 2020-2021,. Results: 53.3% of children have severe autism spectrum disorder; 86.5% of children have quality defects in social relations; 87.5% of children have communication quality defects; 85.2% of children have abnormal behavior defects; There is a relationship between sleep time, family time spent with children, children's time using technology, and the severity of children with autism spectrum disorder.
Inhibition of mild steel corrosion using Tamarind fruit fiber (TFF) extract in three different corrosive media: An experimental and quantum chemical study
Authors: Baluchamy Tamilselvi , Sethuramasamy Padmavathy , Seshian Bhuvaneshwari Durvas , Periyakaruppan Karuppasamy 
Published: January 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Treatment of Urticaria Caused by Severe Cryptosporidiosis in a 17-Month-Old Child – A Case Report and Review of the Literature
Authors: Azami Mehdi , Rarani Saeid Amini , Kiani Fatemeh 
Published: January 2023

Abstract
Background

Cryptosporidium is an intracellular protozoan that causes gastrointestinal symptoms in humans and animals. In immunocompromised patients and children under 5 years of age, the infection is severe and can be life-threatening due to severe diarrhea.

Case presentation

We report a case of urticaria associated with Cryptosporidium in a 17-month-old female Iranian child. The patient had severe diarrhea, weight loss and urticaria. Since the child's father worked in livestock farming, the hypothesis of parasite transmission from cows or calves to the house and the child was proposed. Several Cryptosporidium oocysts were detected in the modified acid-fast staining of the child's stool sample. The patient was successfully treated with nitazoxanide (100 mg twice daily) and became negative for parasites three days after treatment and one week after discharge from the hospital. Her stool pattern normalized in 1 week and she has had no recurrence after 6 months of follow up.

Conclusion

A number of parasites are associated with urticaria, but to our knowledge, there is no information on Cryptosporidium-induced urticaria. Therefore, our result may be evidence for the role of this parasite in the development of urticaria.
Uremic plasma proteins accumulate in peripheral blood mononuclear leukocytes inducing apoptosis: insights in the immuno-proteostasis response of chronic kidney disease.
Authors: Bartolini Desirée , Grignano Maria Antonietta , Piroddi Marta , Chiaradia Elisabetta , Galeazzi Gabriele , Rende Mario , Gioiello Antimo , Rampino Teresa , Libetta Carmelo , Galli Francesco 
Published: January 2023

Abstract
Peripheral blood mononuclear leukocytes (PBL) of uremic patients (u-PBL) prematurely die by apoptosis, thus sustaining leukopenia and immune dysfunction. Uremic retention solutes have been alleged to playing a causal role in this immune cell defect. However, both the molecular identity and pro-apoptotic mechanism of these solutes remain poorly characterized. In this study, we prepared a fraction of the uremic plasma (u-Pl) rich in these solutes (proteinaceous material with molecular weight > 50 kDa, namely the uremic-high MW fraction or u-HMW) that was used to demonstrate their pro-apoptotic activity in u-PBL. Such a detrimental activity was also confirmed in THP-1 and K562 mononuclear cells in association with increased cellular generation and secretion of H2O2, and JNK/cJun-dependent apoptotic signaling downstream of the endoplasmic reticulum stress response protein IRE1-α. The u-HMW also induced autophagy in THP-1 mononuclear leukocytes. These alterations of u-PBL proteostasis were associated with the presence in the proteome of these cells, but not of control PBL, of the main proteins and protein decoration targets (assessed by 2,4-diphenylhydrazine derivatization) of u-Pl and thus of u-HMW, namely albumin, transferrin and fibrinogen. These findings demonstrate that large solutes induce apoptosis in u-PBL leading to abnormal plasma protein endocytosis and terminal alteration of cellular proteostasis mechanisms. We define this response of PBL to large uremic solutes as the “immuno-proteostasis response” (IPR) of uremia.
Non-linear processing with a Surface Acoustic Wave reservoir computer
Authors: Meffan Robert Claude , Ijima Taiki , Banerjee Amit , Hirotani Jun , Tsuchiya Toshiyuki 
Published: January 2023

Abstract
Reservoir computing is a neural network algorithm that reduces the training needed for a neural network to be function. Recently, reservoir computing has been implemented using MEMs devices with prevalent non-linear dynamics to perform non-linear processing tasks. While partially explored in the past, there has been renewed interest in using Surface Acoustic Wave devices as low energy radio-frequency processors. However they have yet to be explored in the reservoir computing framework. In this work, a 39.16 MHz two-port SAW resonator on chemically reduced YZ Lithium Niobate is design and measured. The quality factor, insertion loss, linear transmission, and non-linear transmission of the devices is measured, and the relationship of these properties to reservoir computing is discussed. The SAW resonator is then configured as a time-multiplexed reservoir, and it's non-linear processing capabilities are discussed using the time-delayed parity benchmark.
Identity by descent mapping of HCV spontaneous clearance in populations of diverse ancestry
Authors: Yu Zixuan , Abdel-Azim Salma , Duggal Priya , Vergara Candelaria 
Published: January 2023

Abstract
Background
Acute infection with hepatitis C virus (HCV) affects millions of individuals worldwide. Host genetics plays a role in spontaneous clearance of the acute infection which occurs in approximately 30% of the individuals. Common variants in GPR158, genes in the interferon lambda (IFNL) cluster, and the MHC region have been associated with HCV clearance in populations of diverse ancestry. Fine mapping of those regions has identified some key variants and amino acids as potential causal variants but the role of rare variants in those regions and in the genome, in general, has not been explored. We aimed to detect haplotypes containing rare variants related to HCV clearance using identity-by-descent (IBD) haplotype sharing between unrelated cases/case pairs and case/controls pairs in 3,608 individuals with European and African ancestry.
Results
We detected 1,711,832 and 5,678,043 and individual pairs of IBD segments in the European and African ancestry individuals, respectively. As expected, individuals of African descent had more, and shorter segments compared to Europeans. We did not detect any significant IBD signals in the known associated gene regions.
Conclusions
IBD is based on sharing of haplotypes and is most powerful in populations with a shared founder or recent common ancestor. For the complex trait of HCV clearance, we used two outbred, global populations that limited our power to detect IBD associations. Overall, in this population-based sample we failed to detect rare variations associated with HCV clearance in individuals of European and African ancestry.
Efficacy of aqueous and methanol extracts of Euphorbia wallichii Hook. f. against larval toxocariasis
Authors: Sheikh Mohmad Muzafar , Tak Hidayatullah , Fazili Mustahson F. , Wani Ishfaq Nazir 
Published: January 2023

Abstract
The ever increasing anthelmintic resistance and low efficacy of conventional anthelmintics against larval toxocariasis has created an interest in evaluating plants as an effective source of anthelmintics. The aqueous and methanol extracts of Euphorbia wallichii were evaluated for efficacy against larvae of Toxocara canis both in vitro and in vivo, using an embryogenesis inhibition assay and a larval recovery assay respectively. In the in vitro study (1000) eggs were treated with 0.5, 1, and 2 mg/mL of plant extracts and the positive control was treated with same dose of albendazole. Crude methanol extract of E. wallichii (LC50 1.09 mg/mL) exhibited higher embryogenesis inhibition compared to its crude aqueous extracts (LC50 1.89 mg/mL). In the in vivo study, embryonated eggs (1000) of Toxocara canis were orally inoculated to wistar rats followed by treatment with crude methanol and aqueous extracts of Euphorbia walliachii at concentrations of 100, 200 and 400 mg/Kg and their liver and lungs were examined for the presence of T. canis larvae on the 7th day post infection (dpi). Maximum efficacy (64.75%) in larval count reduction was recorded for crude methanol extract in liver at dose of 400 mg/Kg in liver. Least efficacy (6.25%) in larval count reduction was recorded for crude aqueous extract E. wallichii at dose of 100 mg/Kg in lungs. The results reveal that Euphorbia walliachii extracts has an antitoxocaral effect and warrants further study as to suitability as an alternative anthelmintic.
Participation in Contest Programming: An Examination of Trends in U.S. ICPC Regional Contests
Authors: Blum Jeremy Joseph 
Published: January 2023

Abstract
A wide range of benefits have been posited from participation in programming contests. However, analysis of participation north American regional contests in the International Collegiate Programming Contest (ICPC) shows that participation in these contests is sharply declining, coinciding with the COVID-19 pandemic. Moreover, prior to the pandemic, while the number of teams participating in regional contests was increasing, the number of institutions sending teams to these contests was declining. We find several statistically significant correlations that may underscore structural reasons for this trend. Consistent participation in contests and the number of teams per institution sent to contest both are correlated with likely participation in future contests. On the other end of the spectrum, institutions sending a team to a contest for the first time in three years were much less likely to return in the next year. For this category of teams, if a team is unable to solve any problems in the contest, the institution is significantly less likely to send a team in the next year. Many of these contests have very challenging problem sets, and consequently, have many teams that fail to solve any problems. This result suggests that structuring the problem sets to increase the likelihood that most teams successfully complete problems would broaden participation in these contests.
Genetic and phenotypic parameters for sexual precocity and parasite resistance traits in Nellore cattle
Authors: de Moraes Mariana Mamedes , Gouveia Gabriela Canabrava , Ribeiro Virgínia Mara Pereira , de Araújo Andresa Eva Melo , Cardoso Eduardo Penteado , Toral Fabio Luiz Buranelo 
Published: January 2023

Abstract
Indicator traits of sexual precocity are widely used as selection criteria for the genetic improvement of beef cattle; however, the impact of selection for these traits on resistance to endo- and ectoparasites is unknown. Therefore, this study aimed to estimate the genetic and phenotypic parameters for indicator traits of sexual precocity and parasite resistance in Nellore cattle. The sexual precocity traits evaluated were probability of first calving (PFC) and scrotal circumference at 12 and 18 months of age (SC12 and SC18). The resistance-related traits included tick (TC), gastrointestinal nematode egg (NEC), and Eimeria spp. oocyst (EOC) counts. (Co)variance components were estimated by Bayesian inference using multitrait animal models. The mean heritabilities for PFC, SC12, SC18, TC, NEC and EOC were 0.23, 0.38, 0.42, 0.14, 0.16, 0.06, respectively, and suggest that selection will change the mean values of these traits over time. The genetic and phenotypic correlations for most pairs formed by a precocity and a resistance trait were not different from zero, suggesting that selection for sexual precocity traits will not result in changes in resistance traits. Thus, selection for indicator traits of sexual precocity does not elicit unfavorable correlated responses in resistance to endo- and ectoparasites and joint selection aimed at improving these traits can be performed using multitrait selection methods, when necessary.
Asymmetric load transmission induces facet joint subchondral sclerosis and hypertrophy in patients with idiopathic adolescent scoliosis: Evaluation using finite element model and surgical specimen
Authors: Yahara Yasuhito , Seki Shoji , Makino Hiroto , Futakawa Hayato , Kamei Katsuhiko , Kawaguchi Yoshiharu 
Published: January 2023

Abstract
Background
Physiological and ideal spinal alignment is critical for efficient load transfer to support and maintain our body. However, in patients with adolescent idiopathic scoliosis (AIS), imbalanced load transfer occurs due to abnormal twisting and rotation of the spinal column. This study aimed to investigate the asymmetric stress overload and distribution on the facet joints of AIS patients using finite element (FE) analysis and surgical specimens.
Methods
FE models of the thoracic spine were created from a total of 13 female AIS patients (Lenke type 1, n = 4: Lenke type 2 n = 5; Lenke type 3, n = 4). A load of 200 N on the T3 vertebra and 30 N each on the bilateral superior articular processes were applied in the vertical direction to quantify the contact force on the facet joints from T3 to T11. In addition, morphological and histological analyses were performed on the inferior articular processes taken during surgery.
Results
Contact forces of the facet joint progressively increased from the mid to lower thoracic spine of the concave side, reaching a maximum around the apex. More than 90% of the load was transmitted by the facet joints at the concave side, resulting in facet joint subchondral sclerosis and hypertrophy.
Conclusions
FE models revealed the asymmetric stress overload and distribution on the facet joints of AIS. The asymmetric load transmission could be responsible for degeneration, such as hypertrophy and subchondral sclerosis of the facet joint of AIS.
The impact of access to credit and capitalmarkets on fertility: Evidence from China
Authors: Yu Kaizhi , Chen Xinyue 
Published: January 2023

Abstract
Based on the micro-financial perspective of optimizing householdresource allocation, combined with Becker’s family theory, this paperexamines the impact of broader access to credit and capital marketon household decisions with respect to the number of children by constructinga revised four-period life cycle model. The results show thatloosening borrowing constraints significantly promotes the fertility rate,while opportunities for financial investment inhibits the fertility rate.We find that disposable income weakens the direct positive impact ofcredit quota and promotes the direct negative impact of on fertility.The excessive consumption of households strengthens credit constraintsand encourages household consumption, which accelerates a crowdingout effect on fertility. In addition, endowment insurance prompts households’investment in the capital market, which suppresses reproductivebehavior.
Foster adopting Lean management by public services using BPMN
Authors: Abdelmalek Ismail Ait , Houfaidi Souad 
Published: January 2023

Abstract
Purpose. Governments around the world has tried to rethink, adapt and modify service processes by incorporating methods and tools that have made significant progress in many areas. In this paper, we discuss the possibilities offered by Business Process Management (BPM) tools to public services to adopt Lean management as a continuous improvement process. Methodology. Lean Management is an effective managerial method based on eliminating waste, but which leads only to isolated improvements by improving part of the process. To skirt this problem, we propose to use the BPM tools that allow to connect all activities and easily identify value-added activities in a process. Results. A case study, using Business Process Modelling and Notation (BPMN), allowed us to illustrate the role of BPM in improving a public service process. The theoretical contribution. The current state model (As is) of the process developed by using BPMN2.0 standard, allowed us to highlight qualitative results, we also noted that the employees appreciated the BPMN language and were able to visualize certain weaknesses of the process thanks to this tool. This result is an essential step (identify and eliminate activities with no-added value) to adopt a lean management approach. Practical implications. Articles dealing with the adoption of Lean management in Moroccan public sector are very rare, and even those dealing with the modalities of its adoption are almost absent. This paper is therefore a first in the field and will be a reference for future research.
Genetic analysis of potential biomarkers in cuproptosis from multiple myeloma
Authors: Zhu Yidong , Lin Zhikang , Liu Jun 
Published: January 2023

Abstract
Background
Multiple myeloma (MM) accounts for 1% of neoplastic diseases. Cuproptosis, a copper-triggered modality of mitochondrial cell death, might be a promising therapeutic target for cancer treatment. However, the role of cuproptosis-related genes (CRGs) in MM is not well characterized. Thus, we aimed to explore the diagnostic value of CRGs in MM and further illustrate the potential mechanism.
Methods
The differential expression of CRGs between MM and control samples was identified and validated in the GSE6477 and GSE47552 datasets downloaded from the Gene Expression Omnibus database. The least absolute shrinkage and selection operator (LASSO) and support vector machine-recursive feature elimination (SVM-RFE) algorithms were applied to identify potential CRGs as diagnostic biomarkers for MM. Receiver operating characteristic (ROC) curve analysis was applied to determine the diagnostic performance of the biomarkers. Functional enrichment and correlation analyses were then conducted to figure out the underlying mechanisms.
Results
Based on the differentially expressed CRGs by the gene expression difference of samples, LASSO and SVM-RFE algorithms were used to identify a final number of two CRGs as potential biomarkers for MM: CDKN2A and GLS. The all area under the curve (AUC) values of the 2 marker gene-based logistic regression model were 0.933 and 0.886 in the training and validation cohort, respectively, indicating a good performance in predicting MM diagnosis. Functional enrichment and correlation analyses suggested that the biomarkers may promote MM cell tumorigenesis and survival by modulating the immune cells through its immune-related pathways.
Conclusion
Two CRGs (CDKN2A and GLS) were identified and validated as possible MM biomarkers, which developed a diagnostic potency and provided an insight for exploring the mechanism for MM.
Construction of a Cuproptosis-Related lncRNA Signature for Predicting Prognosis and Immune Response in Cervical Cancer
Authors: Zhang He , Chen Shuning , Kong Weimin , Luo Dan , Zhao Xiaoling , Deng Boer , Xie Yunkai , Pan Zhendong , Qiu Yuchen 
Published: January 2023

Abstract
Background:Cuproptosis is a novel form of cell death, which is triggered by targeted mitochondria that bind the acylated lipid components of the tricarboxylic acid (TCA) cycle. Recent studies have suggested that targeting cuproptosis may be a new treatment strategy for cancer, but its association with cervcal cancer (CC) has not been elucidated.
Methods: Data were downloaded from the TCGA-CESC. The cuproptosis-related lncRNAs were identified and prognostic risk models were constructed. Kaplan-Meier survival analysis, ROC curve, PCA and stratified analysis were used to validate the predictive ability of the model. A nomogram for predicting CC prognosis was established. The biological mechanisms associated with cuproptosis were investigated by GO and KEGG enrichment analysis. The CIBERSORT algorithm, immunoassay and TIDE score were used to measure different immune responses. Finally, we screened for sensitive drugs based on cuproptosis correlation.
Results: We constructed a cuproptosis-related lncRNAs signature as a risk prognostic prediction model. The risk score was proved and the risk model had higher diagnostic efficiency than other features. The Kaplan-Meier curve indicated that lower risk score was significantly associated with better OS rate in training (P<0.001), testing group (P=0.004), and all groups (P<0.001). The time-dependent ROC curves showed the AUC reached 0.738 at 1 year, 0.698 at 3 years, and 0.699 at 5 years. GO and KEGG enrichment analysis found that the DEGs of low- and high-risk groups may be related to immune regulation. Further study of immune cell infiltration demonstrated that cuproptosis-related lncRNAs signature was significantly associated with the immune response of CC. A total of 23 drugs showed significant differences in the semi-inhibitory concentration (IC50) value, suggesting the signature may participate in the influence on drug efficacy.
Conclusions: Our study reveals that assessing cuproptosis patterns in individual tumors will help improve our understanding of the immune mechanisms and prognosis of cervical cancer and thus guide immunotherapy more effectively. Establishing an independent prognostic model based on cuproptosis-associated lncRNAs could serve as a predictor of overall survival and also as a predictor of immunotherapy. The model may help provide personalized medical therapy and new insights into cancer treatment.