bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning d‐Band Center of FeCu Alloy Aerogel Nanozyme Boosting Biosensing and Wound Therapy
Authors: Zhao Fengyang , Wu Wenli , Zhao Mei , Ding Shichao , Yu Li , Hu Qiongzheng 
Published: January 2025

AbstractTransition metals especially Fe‐based catalysts representing an emerging type of enzyme‐mimicking materials are of great interest in biosensing and therapy fields. However, the poor affinity toward H2O2 limits their catalytic activity while high‐precise and controllable regulation of engineering nanozymes remains a challenge. Herein, a facile approach is presented to fabricate FeCu/hemin aerogel nanozymes with self‐supported, hierarchically porous network structures through second metal center and surface ligand engineering, achieving sequential H2O2‐affinity amplification. Excitingly, the affinity of FeCu/hemin nanozymes for H2O2 exhibits a 14.03‐fold enhancement than that of Fe particle, accompanied with 5.88‐fold catalytic efficiency (Kcat/Km) increase than FeCu. Mechanism studies suggest that the metal Cu and hemin modifications upshift the d‐band center of Fe from −0.49 to −0.17 eV and promote electron transfer process, thus facilitating the dissociation of H2O2. Importantly, FeCu/hemin nanozymes allow highly sensitive detection of norfloxacin with a low detection limit of 72 nm. Notably, it shows a remarkable inhibition activity on bacterial growth in vitro and in vivo with no apparent side effects. Therefore, this work not only sheds light on the rational design of nanozymes with highly active and stable properties, but also offers new prospects for the d‐band center tuning to boost enzyme‐mimic activity.
Biomimetic Construction of Ferriporphyrin‐Based Porous Catalysts for Boosting Nitrogen Electroxidation to Nitrate
Authors: He Hongming , Zhang Shan , An Yaxuan , Li Qing , Wang Xinyi , Xu Mingkai , Li Cheng‐Peng , Yang Xinyue , Zhao Yatian , Li Quanshun , Yuan Ye 
Published: January 2025

AbstractElectrocatalytic N2 oxidation reaction (NOR) is an environmentally sustainable approach to synthesize NO3− under mild conditions. Inspired by the ferriporphyrin (FePP) catalytic species in nitrite oxidoreductase, three FePP‐based biomimetic catalysts with different functional groups (─NH2, ─H, and ─COOCH3) are designed and prepared successfully. Theoretical calculations indicate that these functional groups can alter the electron density of Fe catalytic center, affecting their ability to adsorb and activate N2. The strong electron‐donating ability of ─NH2 group can enhance the electron density of iron sites, which reveals a maximum NO3− yield of 728.55 µmol h−1 gFePP−1 and a high Faradaic efficiency of 10.6%. After that, the optimized FePP molecules can be encapsulated into ZIF‐8, which remarkably promoted the N2─to─NO3− transformation with a NO3− production rate of 1767.74 µmol h−1 gFePP−1, achieving the highest catalytic effect among metalloporphyrin‐based molecular catalysts under mild conditions. This work develops an available biomimetic approach to modulate the electron distribution of active metal sites and confine catalytic species into porous crystalline materials for constructing high‐performance NOR electrocatalysts.
Macro/Microgel‐Encapsulated, Biofilm‐Armored Living Probiotic Platform for Regenerating Bacteria‐Infected Diabetic Wounds
Authors: Xin Huilong , Cai Zhe , Hao Jiahui , An Jing , Li Yi , Wen Min , Jia Zhaojun 
Published: January 2025

AbstractInfectious diabetic wounds pose an arduous threat to contemporary healthcare. The combination of refractory biofilms, persistent inflammation, and retarded angiogenesis can procure non‐unions and life‐threatening complications, calling for advanced therapeutics potent to orchestrate anti‐infective effectiveness, benign biocompatibility, pro‐reparative immunomodulation, and angiogenic regeneration. Herein, embracing the emergent “living bacterial therapy” paradigm, a designer probiotic‐in‐hydrogel wound dressing platform is demonstrated. The platform is constructed employing a “macrogel/microgel/biofilm” hierarchical encapsulation strategy, with Lactobacillus casei as the model probiotic. Alginate gels, in both macro and micro forms, along with self‐produced probiotic biofilms, served as encapsulating agents. Specifically, live probiotics are enclosed within alginate microspheres, embedded into an alginate bulk matrix, and cultivated to facilitate biofilm self‐encasing. This multiscale confinement protected the probiotics and averted their inadvertent escape, while enabling sustained secretion, proper reservation, and localized delivery of therapeutically active probiotic metabolites, such as lactic acid. The resulting biosystem, as validated in vitro/ovo/vivo, elicited well‐balanced antibacterial activities and biological compatibility, alongside prominent pro‐healing, vasculogenic and anti‐inflammatory potencies, thus accelerating the regeneration of infected full‐thickness excisional wounds in diabetic mice. Such multiple encapsulation‐engineered “all‐in‐one” probiotic delivery tactic may shed new light on the safe and efficient adoption of live bacteria for treating chronic infectious diseases.
Advanced Carriers for Precise Delivery and Therapeutic Mechanisms of Traditional Chinese Medicines: Integrating Spatial Multi‐Omics and Delivery Visualization
Authors: Zhang Yusheng , Lu Zhiguo , Guo Jing , Wang Qing , Zhang Xin , Yang Hongjun , Li Xianyu 
Published: January 2025

AbstractThe complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance of bioactive compounds that make them valuable resources for disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise disease treatment. This involves elucidating the structure‐activity relationships within their complex compositions, ensuring accurate in vivo delivery, and monitoring the delivery process. This review discusses the research progress of TCMs in precision disease treatment from three perspectives: spatial multi‐omics technology for precision therapeutic activity, carrier systems for precise in vivo delivery, and medical imaging technology for visualizing the delivery process. The aim is to establish a novel research paradigm that advances the precision therapy of TCMs.
Trojan Horse‐Like Biohybrid Nanozyme for Ameliorating Liver Ischemia‐Reperfusion Injury
Authors: Zheng Dao‐Feng , Zha Xiang‐Jun , Jiang En‐Lai , Qiu Yuan , Yang Wei , Xiao Wei‐Dong 
Published: January 2025

AbstractLiver ischemia and reperfusion (I/R) injury is a reactive oxygen species (ROS)‐related disease that occurs during liver transplantation and resection and hinders postoperative liver function recovery. Current approaches to alleviate liver I/R injury have limited effectiveness due to the short circulation time, poor solubility, and severe side effects of conventional antioxidants and anti‐inflammatory drugs. Herein, a universal strategy is proposed to fabricate a Trojan horse‐like biohybrid nanozyme (THBN) with hepatic‐targeting capabilities. Tannic acid (TA) mediates adeno‐associated virus (AAV8) decoration onto 2D Ti3C2 nanosheets, resulting in THBN with a size of 116.2 ± 9.5 nm. Remarkably, THBN exhibits catalase (CAT)‐like activity, broad‐spectrum ROS scavenging activity and targeted delivery to liver tissue owing to the presence of AAV8. Both in vivo and in vitro experiments confirmed the efficacy of THBN in attenuating liver I/R injury by mitigating inflammation and oxidative stress and inhibiting hepatocellular apoptosis. RNA‐seq analysis suggests that THBN may alleviate liver I/R injury by activating the PKC pathway. The effective targeting and therapeutic capabilities of THBN represent an advancement in nanotherapeutics for hepatic ischemia‒reperfusion injury, shedding light on the promising potential of this next‐generation nanotherapeutic approach.
Acceptor Elongation Boosted Intersystem Crossing Affords Efficient NIR Type‐I and AIE‐Active Photosensitizers for Targeting Ferroptosis‐Based Cancer Therapy
Authors: Zhu Yilin , Zhang Rongyuan , Cai Xu‐Min , Zhang Liping , Wu Bo , Tan Haozhe , Zhou Kun , Wang Haoran , Liu Yong , Luo Yumei , Kwok Ryan T. K. , Lam Jacky W. Y. , Zhao Zheng , Yao Cuiping , Tang Ben Zhong 
Published: January 2025

AbstractPhotosensitizers (PSs) featuring type I reactive oxygen species (ROS) generation and aggregation‐induced emission (AIE) activity offer a promising solution to achieve non‐invasive and precise theranostics. However, the reported AIE luminogens (AIEgens) with both AIE characteristic and strong type‐I ROS generation are still scarce and the structure‐property relationship is still unclear. Herein, an innovative acceptor elongation boosted intersystem crossing (AEBIC) design strategy has been proposed to endow the AIEgen strong type‐I ROS producibility. The results indicate that the obtained AIEgen exhibit type‐I ROS and aggregation‐enhanced ROS efficacy, which has been verified by both experimental and theoretical results. Mechanistic study reveal that the acceptor elongation has promoted a dual‐channel intersystem crossing pathway to enhance the intersystem crossing (ISC) process due to the differences in triplet configurations, which can be further amplified by aggregation. The afforded type‐I AIE‐PS show lipid droplet‐anchored characteristic and can induce the ferroptosis through destroying the cellular redox homeostasis and increasing lethal levels of lipid peroxidation. Finally, targeting ferroptosis‐based cancer therapy can be realized with excellent anti‐tumor effect.
Integration of Through‐Sapphire Substrate Machining with Superconducting Quantum Processors
Authors: Acharya Narendra , Armstrong Robert , Balaji Yashwanth , Crawford Kevin G. , Gates James C. , Gow Paul C. , Kennedy Oscar W. , Pothuraju Renuka Devi , Shahbazi Kowsar , Shelly Connor D. 
Published: January 2025

AbstractA sapphire machining process integrated with intermediate‐scale quantum processors is demonstrated. The process allows through‐substrate electrical connections, necessary for low‐frequency mode‐mitigation, as well as signal‐routing, which are vital as quantum computers scale in qubit number, and thus dimension. High‐coherence qubits are required to build fault‐tolerant quantum computers and so material choices are an important consideration when developing a qubit technology platform. Sapphire, as a low‐loss dielectric substrate, has shown to support high‐coherence qubits. In addition, recent advances in material choices such as tantalum and titanium‐nitride, both deposited on a sapphire substrate, have demonstrated qubit lifetimes exceeding 0.3 ms. However, the lack of any process equivalent of deep‐silicon etching to create through‐substrate‐vias in sapphire, or to inductively shunt large dies, has limited sapphire to small‐scale processors, or necessitates the use of chiplet architecture. Here, a sapphire machining process that is compatible with high‐coherence qubits is presented. This technique immediately provides a means to scale quantum processing units (QPUs) with integrated mode‐mitigation, and provides a route toward the development of through‐sapphire‐vias, both of which allow the advantages of sapphire to be leveraged as well as facilitating the use of sapphire‐compatible materials for large‐scale QPUs.
Novel Magnetic‐Field‐Free Switching Behavior in vdW‐Magnet/Oxide Heterostructure
Authors: Keum Jihoon , Zhang Kai‐Xuan , Cheon Suik , Kim Hyuncheol , Cui Jingyuan , Park Giung , Chang Yunyeong , Kim Miyoung , Lee Hyun‐Woo , Park Je‐Geun 
Published: January 2025

AbstractMagnetization switching by charge current without a magnetic field is essential for device applications and information technology. It generally requires a current‐induced out‐of‐plane spin polarization beyond the capability of conventional ferromagnet/heavy‐metal systems, where the current‐induced spin polarization aligns in‐plane orthogonal to the in‐plane charge current and out‐of‐plane spin current. Here, a new approach is demonstrated for magnetic‐field‐free switching by fabricating a van‐der‐Waals magnet and oxide Fe3GeTe2/SrTiO3 heterostructure. This new magnetic‐field‐free switching is possible because the current‐driven accumulated spins at the Rashba interface precess around an emergent interface magnetism, eventually producing an ultimate out‐of‐plane spin polarization. This interpretation is further confirmed by the switching polarity change controlled by the in‐plane initialization magnetic fields with clear hysteresis. Van‐der‐Waals magnet and oxide are successfully combined for the first time, especially taking advantage of spin‐orbit torque on the SrTiO3 oxide. This allows this study to establish a new way of magnetic field‐free switching. This work demonstrates an unusual perpendicular switching application of large spin Hall angle materials and precession of accumulated spins, and in doing so, opens up a new field and opportunities for van‐der‐Waals magnets and oxide spintronics.
Ten Years of Perovskite Lasers
Authors: Shi Ying , Deng Xinyi , Gan Yusong , Xu Luobing , Zhang Qing , Xiong Qihua 
Published: January 2025

AbstractOver the past decade, semiconducting halide perovskite lasers have emerged as a transformative platform in optoelectronics, owing to unique properties such as high photoluminescence quantum yields, tunable bandgaps, and low‐cost fabrication processes. This review systematically examines the advancements in halide perovskite lasers, covering diverse laser architectures, such as whispering gallery mode, Fabry–Pérot, plasmonic, bound states in the continuum (BIC), quantum dot, and polariton lasers. The mechanisms of optical gain, the role of material engineering in optimizing lasing performance, and the challenges associated with continuous‐wave (CW) pumping and electrically driven lasing are discussed. Furthermore, recent progress in improving the stability and scalability of perovskite lasers, essential for their integration into practical applications in displays, optical communications, sensing, and integrated photonics is highlighted. Finally, future research directions are discussed, emphasizing the potential of perovskite lasers to revolutionize various technological domains by enabling the development of next‐generation photonic devices.
Size‐Dependent Cascade Enhancement of T1‐T2 Dual‐Modal MRI in Tumors
Authors: Yang Yanyun , Zheng Yifan , Tong Tong , Dong Jiajing , Zhao Miaoxin , Zhang Guangtao , Yu Zian , Dong Ling , Jiang Jinhui , Yuan Yue 
Published: January 2025

AbstractCurrently, there is no conclusive evidence indicating that in situ self‐assembled Gd nanostructures of varying sizes demonstrate distinct T1 and T2 signal enhancement capabilities. Furthermore, it remains uncertain whether size adjustment can effectively achieve enhanced T1‐T2 dual‐modal MRI. To address these uncertainties, a two‐step in situ self‐assembly strategy is developed. This approach began with a small‐sized nanoprobe, Gd‐TCO‐P, with a hydrodynamic diameter (dH) of 16 ± 3 nm. This nanoprobe underwent alkaline phosphatase (ALP) cleavage and self‐assembled intracellularly into short nanofibers termed Gd‐NFs (dH: 200 ± 51 nm). The subsequent introduction of tetrazine‐tetrazine crosslinked these Gd‐NFs, leading to the formation of larger two‐stage dendritic nanofibers known as Gd‐TS‐NFs (dH: 4371 ± 236 nm). This process achieves size‐dependent enhancement of both T1 and T2 signals, which is validated through both in vitro and in vivo experiments, enabling precise long‐term imaging of ALP‐overexpressing tumors. This study not only provides valuable insights into the relationship between the size of in situ formed Gd nanostructures and T1/T2 MRI contrast enhancement, but also suggests a promising strategy for clinical applications of T1‐T2 dual‐modal MRI.
Synergistic Adhesion and Shape Deformation in Nanowire‐Structured Liquid Crystal Elastomers
Authors: Dupont Robert L. , Xu Yang , Borbora Angana , Wang Xinyu , Azadi Fatemeh , Havener Kaden , Lewis Broderick , Deng Weichen , Tan Benjamin W. , Li Shucong , Zhang Rui , Yao Yuxing , Manna Uttam , Wang Xiaoguang 
Published: January 2025

AbstractNature provides many examples of the benefits of nanoscopic surface structures in areas of adhesion and antifouling. Herein, the design, fabrication, and characterization of liquid crystal elastomer (LCE) films are presented with nanowire surface structures that exhibit tunable stimuli‐responsive deformations and enhanced adhesion properties. The LCE films are shown to curl toward the side with the nanowires when stimulated by heat or organic solvent vapors. In contrast, when a droplet of the same solvent is placed on the film, it curls away from the nanowire side due to nanowire‐induced capillary forces that cause unequal swelling. This characteristic curling deformation is shown to be reversible and can be optimized to match curved substrates, maximizing adhesive shear forces. By using chemical modification, the LCE nanowire films can be given underwater superoleophobicity, enabling oil repellency under a range of harsh conditions. This is combined with the nanowire‐induced frictional asymmetry and the reversible shape deformation to create an underwater droplet mixing robot, capable of performing chemical reactions in aqueous environments. These findings demonstrate the potential of nanowire‐augmented LCE films for advanced applications in soft robotics, adaptive adhesion, and easy chemical modification, with implications for designing responsive materials that integrate mechanical flexibility with surface functionality.
Fluorine Doping‐Assisted Reconstruction of Isolated Cu Sites for CO2 Electroreduction Toward Multicarbon Products
Authors: Jia Chen , Tan Xin , Sun Qian , Liu Ruirui , Hocking Rosalie K. , Wang Shuhao , Zhong Li , Shi Zhun , Smith Sean , Zhao Chuan 
Published: January 2025

AbstractThe electrocatalytic synthesis of multicarbon compounds from CO2 is a promising method for storing renewable electricity and addressing global CO2 issues. Single‐atom catalysts are promising candidates for CO2 reduction, but producing high‐value multicarbon (C2+) products using a single‐atom structure remains a significant challenge. In this study, a fluorine doping strategy is proposed to facilitate the reconstruction of isolated Cu atoms, promoting multicarbon generation. The in situ formed Cu nanocrystals contain a substantial amount of stable Cu+ species, demonstrating remarkable activity for CO2−to‐multicarbon conversion. Notably, they achieve the highest Cu utilization, with a C2+ partial current density of −2.01 A mgper Cu−1and a C2+ formation rate of 7.03 mmol h−1 mgper Cu−1at ≈−1 V versus RHE. In situ Raman spectroscopy and density functional theory calculations confirm the crucial role of fluorine atoms in structural evolution and electrolysis.
Elastic and Conductive Photocatalytic Membrane
Authors: Luo Lingdi , Zhao Qi , Yang Yawei , Wu Tao , Qiang Mengyuan , Que Wenxiu 
Published: January 2025

AbstractThe development of photocatalytic membranes using electrospinning technology has significantly advanced their practical applications. However, current photocatalytic membranes are encountering the issues of poor mechanical property in non‐elastic fiber and low charge carrier separation efficiency in non‐conductive polymer. Through improving thermoplastic polyurethane (TPU) precursor dissolution and adding conductive polyaniline (PANI) respectively before and after electrospinning, TiO2‐based elastic conductive (EC) TPU membranes with higher mechanical strength and photocatalytic performance are created, compared to traditional inelastic non‐conductive (IN) membrane, even to inelastic conductive (IC) membrane. The nanofibers in the TiO2 EC membrane have a relatively rough surface structure, which exposes more catalytic sites. Ultraviolet photoelectron spectrum (UPS) test results show that the work function (φ) of TiO2 in EC membrane becomes lower than in IN and IC membranes, leading to the strongest electron transfer potential for photocatalytic reactions. For the photocatalytic degradation of Methyl Orange (MO), the TiO2 EC membrane demonstrates the best degradation rate of 49.43% over 3 days among three samples. These findings suggest that the TiO2 EC membrane is promising for in‐site micropollutant water treatment in the real‐world.
Unconventional Solvent‐Doping‐Induced Ultrahigh Carrier Mobility Leads to Excellent Thermoelectric Performance in Eco‐Friendly Bi2S3 and SnS
Authors: Wu Fanshi , Shi Yifan , Huang Xiaoqing , Chen Zhengchong , Zhang Hongjun , Wang Xiyang , Huang Ming , Fu Liangwei , Lou Yue , Xu Biao 
Published: January 2025

AbstractConventional aliovalent doping, which involves replacing host atoms with solute ones, is a well‐established strategy in wet chemical synthesis for enhancing semiconductor performance. However, this method faces serious challenges like low solubility and unavoidable carrier mobility loss, which hinder significant performance improvements, particularly in thermoelectrics. Herein, a novel solvent‐doping strategy is reported that effectively improves the carrier concentration in nanocrystals by stabilizing cation or anion vacancies. Density functional theory calculations and pair distribution function tests reveal that solvent doping increases the atomic ordering and reduces deformation potential, thereby significantly enhancing carrier mobility. Additionally, the conversion of solvent molecules into carbon contributes to further suppressing the lattice thermal conductivity in substrates. As a result, a record‐high peak ZT value of ≈1.0 and a measured thermoelectric conversion efficiency of 1.47% are obtained in solvent‐doped Bi2S3. Similarly, SnS exhibits a remarkable increase of ≈150% in the peak ZT value following solvent doping. This study demonstrates the application of solvent‐doping strategy in thermoelectrics and suggests the potential in other fields, such as transistors, photovoltaic, and catalysis.
Impact of Socio‐Demographic Factors and Handling Practices on Post‐Harvest Fish Losses in Kakamega County's Cultured Tilapia Value Chain
Authors: Obar James Adero , Matofari Joseph Wafula , Nduko John Masani 
Published: January 2025

ABSTRACTPost‐harvest fish losses (PHFL) significantly impact the aquaculture sector in Kenya, undermining food security and economic growth. This study investigated socio‐demographic factors and handling practices influencing PHFL in Kakamega County's cultured tilapia value chain. Data were collected from 94 value chain actors operating across multiple nodes, including farming, processing and retail stages from six sub‐counties using surveys and observations. Results revealed that 64% of participants were female, and 40.3% had completed high school, with only 26.6% holding valid food handler certificates. Household sizes mostly ranged from 4 to 9 members, and experience in the value chain varied, with 33% having 5–10 years of experience and 17% had over 21 years of experience. PHFL were significant across nodes, with farm gate losses highest in Butere (32%) and lowest in Likuyani (8.42%). Wholesale and retail losses were also notable, with Mumias East showing the highest overall losses. Regression analysis identified key predictors of PHFL, including poor sanitary conditions, lack of training, inadequate water quality and cooling practices, explaining 87.2% of the variance in PHFL. Experience negatively correlated with PHFL (r = −0.354, p < 0.01), indicating that more experienced individuals incurred lower losses. Chi‐square tests showed significant associations between PHFL and factors like household size, occupation, training and sanitation but not gender, education or age. The findings highlight the need for targeted interventions, including training programmes, infrastructure improvements and adherence to food safety standards, to minimise PHFL, improve fish quality and enhance food and nutrition security in Kakamega County.