bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients
Authors: Schmidt Martina E. , Chong Marvin , Klassen Oliver , Wiskemann Joachim , Steindorf Karen 
Published: June 2023

AbstractCancer‐related fatigue is commonly treated in an undifferentiated manner, because its pathophysiology is still not well understood. Therefore, we investigated if bioelectrical phase angle (PhA), a non‐invasive marker of cell integrity, could help to single out specific fatigue subtypes. In a randomized controlled strength training intervention trial, PhA was measured by bioelectrical impedance analysis in 158 breast cancer patients. Fatigue was assessed with the multidimensional 20‐item Fatigue Assessment Questionnaire. Multiple regression analyses considering changes in PhA and fatigue from baseline to post‐intervention and ANCOVA models investigating the strength training effect on PhA were conducted. Further, explorative mediation and moderation analyses were performed. Decrease (=worsening) in PhA was significantly associated with increase in physical (P = .010) and emotional (P = .019) fatigue. These associations were markedly stronger in patients with normal BMI (interaction P = .059 and .097) and with low pre‐diagnosis exercise level (interaction P = .058 and .19). Among patients with normal BMI strength training was associated with an increase in PhA (ANCOVA P = .059), but not among overweight/obese patients (interaction P = .035). Chemotherapy was a major determinant for low PhA, but PhA did not mediate the effect of chemotherapy on fatigue. In conclusion, PhA has a significant inverse association with physical and emotional fatigue. This association is moderated by BMI and previous exercise. Significant relationships of PhA were also observed with chemotherapy and strength training. Thus, PhA might be a marker that could help in the classification of subtypes of fatigue with different pathophysiology, which may require specifically tailored treatment. Further research on this is warranted.
Coupling men‐to‐women: Promoting innovation in emerging markets
Authors: Machokoto Michael , Lemma Tesfaye T. , Dsouli Ouarda , Fakoussa Rebecca , Igudia Eghosa 
Published: June 2023

AbstractMotivated by calls to explore corporate outcomes of gender diversity‐related dependencies in a firm's upper echelons, we examine whether gender diversity in manager‐owner(s) teams shapes innovation. Using the context of emerging markets and a large surveydataset drawn from the Business Environment and Enterprise Performance Survey (BEEPS), we find robust evidence suggesting that gender‐diverse manager‐owner(s) teams are associated with higher odds of undertaking innovation. Specifically, women (men) owned firms managed by a male (female) top manager are associated with a higher likelihood of undertaking innovation relative to women (men) owned firms managed by women (men). Additionally, we find that female‐owned firms run by male (female) top managers are the most (least) innovative and male‐owned firms run by female (male) top managers are the second (third) innovative. Our findings indicate that heterophilic manager‐owner(s) teams have the potential to foster innovation in emerging markets. More importantly, our results suggest that initiatives promoting manager‐owner(s) team's gender diversity have the potential to overcome the social and structural barriers that impede innovation in emerging economies.
Why has plasma exchange failed in TRACK syndrome? Lessons from a new variant of the atypical hemolytic uremic syndrome
Authors: Durak Cansu , Sahin Ebru Guney , Yusuf Can Yasar , Varol Fatih , Cam Halit 
Published: June 2023

AbstractAtypical hemolytic uremic syndrome (aHUS) is a rare and life‐threatening form of thrombotic microangiopathy, associated with high mortality and morbidity. Most cases present with hemolytic anemia, thrombocytopenia, and renal insufficiency. However, it can have unusual multiple end‐organ injuries including extrarenal organ and system involvements such as neurologic, cardiac, gastrointestinal, and respiratory systems. We describe a 4‐year‐old girl who developed aHUS due to the TSEN2 mutation and had cardiac involvement. She did not benefit from plasma exchange, as stated in previous cases. It should be kept in mind that therapeutic plasma exchange may not be beneficial in some cases of aHUS, especially due to genetic mutations.
A rare cause of intellectual disability: Novel mutations of NFIX gene in two patients with clinical features of Marshall–Smith syndrome and Malan syndrome
Authors: Uzman Ceren Yılmaz , Gürsoy Semra , Hazan Filiz 
Published: June 2023

AbstractMarshall–Smith syndrome (MSS) and Malan syndrome (MS) are both allelic disorders caused by mutations in the NFIX gene. MS is characterized by overgrowth, intellectual disability, distinctive facial features, and accelerated skeletal maturation. On the other hand, clinical features of MSS consist of advanced bone age, dysmorphic features, intellectual disability, and failure to thrive at birth. In this study, we presented the clinical and molecular findings of two different patients with MS and MSS as a rare cause of intellectual disability and reported two novel variants in the NFIX gene. NFIX gene sequencing revealed a novel heterozygous c.1287delC (p.G430Vfs*34) mutation in patient 1 whose clinical diagnosis was compatible with Marshall–Smith syndrome, and in the second patient, physical features consistent with Malan syndrome, was detected a heterozygous one nucleotide duplication, c.303dupC (pCys102LeufsTer17).
Permeabilized whole cells containing co‐expressed cyclomaltodextrinase and maltooligosyltrehalose synthase facilitate the synthesis of nonreducing maltoheptaose (N‐G7) from β‐cyclodextrin
Authors: Zheng Luhua , Zhou Ruiqi , Jiang Bo , Chen Jingjing , Hu Miaomiao , Zhang Tao 
Published: June 2023

AbstractBACKGROUNDMaltodextrin is an important bulk ingredient in food and other industries; however, drawbacks such as uneven polymerization and high reducibility limit its utilization. Nonreducing maltoheptaose (N‐G7) is a good substitute for maltodextrin owing to its single degree of polymerization and its nonreducing properties. In this study, in vitro cell factory biotransformation of β‐cyclodextrin (β‐CD) to N‐G7 is demonstrated using coexpressed cyclomaltodextrinase (CDase, EC 3.2.1.54) and maltooligosyltrehalose synthase (MTSase, EC 5.4.99.15). However, the cell membrane prevents β‐CD from entering the cell owing to its large diameter.RESULTSThe amylase‐deficient permeabilized host ΔycjM‐ΔmalS‐ΔlpxM is utilized for the coexpression of recombinant CDase and MTSase. Deletion of lpxM effectively allows the entry of β‐cyclodextrin into the cell, despite its large diameter, without requiring any relevant cell membrane permeability‐promoting reagent. This results in a 28.44% increase in the efficiency of β‐CD entry into the cell, thus enabling intracellular N‐G7 synthesis without the extracellular secretion of recombinant CDase and MTSase. After reacting for 5.5 h, the highest purity of N‐G7 (65.50%) is obtained. However, hydrolysis decreases the purity of N‐G7 to 49.30%, thus resulting in a conversion rate of 40.16% for N‐G7 when the reaction lasts 6 h. Precise control of reaction time is crucial for obtaining high‐purity N‐G7.CONCLUSIONWhole‐cell catalysis avoids cell fragmentation and facilitates the creation of an eco‐friendly, energy‐efficient biotransformation system; thus, it is a promising approach for N‐G7 synthesis. © 2023 Society of Chemical Industry.
The expression levels of circulating miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in acute ischemic stroke
Authors: Ju Hong‐Yan , Tang Shan‐Shan , Li Bang‐Jing , Luo Xi , Li Qi 
Published: June 2023

AbstractPlasma miRNAs can characterize several diseases, including acute ischemic stroke (AIS), which is noninvasive and currently affordable in most laboratories worldwide. We aimed to demonstrate plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in AIS.GSE110993 and GSE86291 datasets were analyzed to obtain plasma differentially expressed miRNAs between AIS and healthy control subjects (HCs). We further applied RT‐qPCR for the validation in 85 AIS patients and 85 HCs. Receiver operating characteristic (ROC) curve were conducted to evaluate their diagnostic utility in AIS. Correlation was analyzed between DEmiRNAs and clinical and laboratory parameters, as well as inflammatory markers. The plasma levels of miR‐140‐3p, miR‐130a‐3p, and miR‐320b were found to be consistently altered in both GSE110993 and GSE86291 datasets. In comparison to HCs, AIS patients at admission exhibited lower levels of miR‐140‐3p and miR‐320b and higher level of miR‐130a‐3p in their plasma. The ROC analysis revealed that plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b had area under the curve values of 0.790, 0.831, and 0.907, respectively. When combined, these miRNAs showed superior discriminatory power with a sensitivity of 91.76% and specificity of 95.29%. Plasma miR‐140‐3p and miR‐320b negatively correlated glucose levels and inflammatory markers (IL‐6, MMP‐2, MMP‐9, and VEGF) in AIS patients. Conversely, plasma miR‐130a‐3p levels were positively associated with glucose levels and these markers. Plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b levels varied significantly among AIS patients with different NIHSS scores. Plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b had high diagnostic value in AIS patients, which were correlated with inflammation and severity in stroke.
Suture Stenting After Sialendoscopy: A Novel Technique That Reduces Risk of Recurrent Parotitis
Authors: Finegersh Andrey , Chang Julia , Lee Yu‐Jin , Sirjani Davud 
Published: June 2023

ObjectiveChronic sialadenitis is associated with decreased quality of life and recurrent infections. While sialendoscopy with stenting is effective in relieving symptoms of sialadenitis, currently available stents are rigid and poorly tolerated by patients, leading to early removal and potential for adverse scarring. This study examines whether sutures can be used as a stenting material to improve patient comfort and reduce recurrence risk.MethodsThis is a retrospective cohort study of a consecutive series of adult patients with chronic sialadenitis undergoing sialendoscopy with or without suture stenting. Data were collected between 2014 and 2018 with a 3‐year follow‐up period ending in 2021. The primary outcome measure was recurrence of sialadenitis within 3 years of surgery. Secondary outcomes were stent dislodgement and patient‐reported discomfort.ResultsWe included 63 patients with parotid sialadenitis of whom 28 underwent suture stenting and 35 did not receive stenting after sialendoscopy. Stents were well tolerated, with a mean duration of 34.5 days, and only 2 of 28 stents (7.1%) accidentally dislodged within the first week. Suture stenting significantly reduced symptom recurrence after sialendoscopy (OR = 0.09, 95% CI 0.02–0.45, p = 0.003; 3‐year sialadenitis recurrence rate: 7.1% vs. 45.7%, p = 0.005). Cox multivariate regression for clinicodemographic variables showed an HR of 0.04 (95% CI 0.01–0.19, p < 0.001) for the risk of symptom recurrence.Conclusions and relevanceSuture stenting after sialendoscopy is low cost, available across all institutions, well‐tolerated by patients, and highly efficacious in reducing risk of recurrent sialadenitis after sialendoscopy.Level of Evidence3 Laryngoscope, 134:614–621, 2024
Multilayer Polymer Shell Perfluoropentane Nanodroplets for Multimodal Ultrasound, Magnetic Resonance, and Optoacoustic Imaging
Authors: Maksimova Elizaveta A. , Nozdriukhin Daniil , Kalva Sandeep Kumar , Lyu Shuxin , Lafci Berkan , Augath Mark‐Aurel , Rudakovskaya Polina G. , Solovev Alexander A. , Mei Yongfeng , Deán‐Ben Xosé Luís , Razansky Daniel , Gorin Dmitry A. 
Published: June 2023

AbstractMultimodal imaging increases the value of stand‐alone modalities by enabling simultaneous multiparametric characterization of biological tissues in vivo. Particularly, optoacoustic (OA) tomography has enabled bringing optical imaging advantages to previously unattainable depths and is currently being hybridized with other imaging technologies for enhanced performance. The full potential of these multimodal imaging approaches can only be achieved with dedicated contrast agents ensuring simultaneous measurements and accurate co‐registration of the information provided. Herein, perfluoropentane‐filled nanodroplets are modified, providing excellent contrast in ultrasound imaging, by introducing shell‐embedded additives offering strong contrast in magnetic resonance and OA imaging. Magnetite nanoparticles and indocyanine green (ICG) dye are simultaneously deposited as a multilayer shell on the droplets with the layer‐by‐layer method. This results in sufficiently high amounts of magnetite (0.54 ± 0.08 mg mL−1) and ICG (0.30 ± 0.08 mg mL−1) for efficient magnetic resonance and OA detection, respectively. The high sensitivity achieved with the developed trimodal nanodroplets is first demonstrated in phantom experiments, after which their potential toxic effects, biodistribution, and clearance are examined in vitro and in vivo. Taken together, the obtained results indicate that the developed multilayer polymer shell nanodroplets are efficient hybrid contrast agents for multimodal biomedical imaging applications.
Who leaps first: Status quo of the leapfrogging phenomenon
Authors: Killmer Jan F. 
Published: June 2023

AbstractIn an economic environment, the leapfrogging phenomenon manifests itself in various facets and makes it possible to skip stages of development or product generations. However, an overview of the actors that are involved, how they are connected, and the effects that leapfrogging can have is missing. This article thus focuses on identifying relevant research contributions and analyzing their content by text mining. The results reveal that various actors engage in leapfrogging and that this phenomenon plays a major role in the development of countries, for instance. Firms and industries also pursue leapfrogging, for example, to take leading positions in the market (business strategies). An area of research that has received little attention thus far addresses the leapfrogging behavior of consumers. Technological leapfrogging also combines numerous elements of this phenomenon. Therefore, this article derives many relevant topics for research and practice to investigate this phenomenon in a more accurate and targeted manner.
Technical note: Feasibility of gating for dynamic trajectory radiotherapy – Mechanical accuracy and dosimetric performance
Authors: Loebner Hannes A. , Frauchiger Daniel , Mueller Silvan , Guyer Gian , Mackeprang Paul‐Henry , Stampanoni Marco F. M. , Fix Michael K. , Manser Peter , Bertholet Jenny 
Published: June 2023

AbstractBackgroundDynamic trajectory radiotherapy (DTRT) extends state‐of‐the‐art volumetric modulated arc therapy (VMAT) by dynamic table and collimator rotations during beam‐on. The effects of intrafraction motion during DTRT delivery are unknown, especially regarding the possible interplay between patient and machine motion with additional dynamic axes.PurposeTo experimentally assess the technical feasibility and quantify the mechanical and dosimetric accuracy of respiratory gating during DTRT delivery.MethodsA DTRT and VMAT plan are created for a clinically motivated lung cancer case and delivered to a dosimetric motion phantom (MP) placed on the table of a TrueBeam system using Developer Mode. The MP reproduces four different 3D motion traces. Gating is triggered using an external marker block, placed on the MP. Mechanical accuracy and delivery time of the VMAT and DTRT deliveries with and without gating are extracted from the logfiles. Dosimetric performance is assessed by means of gamma evaluation (3% global/2 mm, 10% threshold).ResultsThe DTRT and VMAT plans are successfully delivered with and without gating for all motion traces. Mechanical accuracy is similar for all experiments with deviations <0.14° (gantry angle), <0.15° (table angle), <0.09° (collimator angle) and <0.08 mm (MLC leaf positions). For DTRT (VMAT), delivery times are 1.6–2.3 (1.6– 2.5) times longer with than without gating for all motion traces except one, where DTRT (VMAT) delivery is 5.0 (3.6) times longer due to a substantial uncorrected baseline drift affecting only DTRT delivery. Gamma passing rates with (without) gating for DTRT/VMAT were ≥96.7%/98.5% (≤88.3%/84.8%). For one VMAT arc without gating it was 99.6%.ConclusionGating is successfully applied during DTRT delivery on a TrueBeam system for the first time. Mechanical accuracy is similar for VMAT and DTRT deliveries with and without gating. Gating substantially improved dosimetric performance for DTRT and VMAT.
Quality of working life of employees in public healthcare organization in Finland: A cross‐sectional study
Authors: Kesti Reetta , Kanste Outi , Konttila Jenni , Oikarinen Anne 
Published: June 2023

AbstractAimWork dissatisfaction, burnout and workforce shortage are major problems in healthcare globally, all of which are associated with QWL. Previous studies have found that the QWL of healthcare professionals is moderate or low. The aim was to describe the quality of working life (QWL) of employees working in public healthcare and describe the association between QWL and background variables.DesignThis study had a quantitative cross‐sectional survey design.MethodsData was collected from the employees of a Finnish healthcare organization in autumn 2021 using an online questionnaire (n = 837). Convenience sampling was used in the selection of the healthcare organization. The study was reported according to STROBE guidelines.ResultsThe QWL was moderate, and the mean QWL index calculated from the questionnaire responses was 0.524. The QWL index was lowest in healthcare professionals and highest in upper management, with some dissatisfaction towards leadership noted.
Correlations among morphological and biochemical traits in high‐cannabidiol hemp (Cannabis sativa L.)
Authors: Stack George M. , Carlson Craig H. , Toth Jacob A. , Philippe Glenn , Crawford Jamie L. , Hansen Julie L. , Viands Donald R. , Rose Jocelyn K. C. , Smart Lawrence B. 
Published: June 2023

AbstractCannabis sativa is cultivated for multiple uses including the production of cannabinoids. In developing improved production systems for high‐cannabinoid cultivars, scientists and cultivators must consider the optimization of complex and interacting sets of morphological, phenological, and biochemical traits, which have historically been shaped by natural and anthropogenic selection. Determining factors that modulate cannabinoid variation within and among genotypes is fundamental to developing efficient production systems and understanding the ecological significance of cannabinoids. Thirty‐two high‐cannabinoid hemp cultivars were characterized for traits including flowering date and shoot‐tip cannabinoid concentration. Additionally, a set of plant architecture traits, as well as wet, dry, and stripped inflorescence biomass were measured at harvest. One plant per plot was partitioned post‐harvest to quantify intra‐plant variation in inflorescence biomass production and cannabinoid concentration. Some cultivars showed intra‐plant variation in cannabinoid concentration, while many had a consistent concentration regardless of canopy position. There was both intra‐ and inter‐cultivar variation in architecture that correlated with intra‐plant distribution of inflorescence biomass, and concentration of cannabinoids sampled from various positions within a plant. These relationships among morphological and biochemical traits will inform future decisions by cultivators, regulators, and plant breeders.
Observer‐based robust control for N‐coupled wave equations
Authors: Meng Tingting , Guo Bao‐Zhu 
Published: June 2023

AbstractIn this article, we consider robust output regulation for an MIMO wave system with disturbance and reference produced from an exosystem. The approach we adopt is the observer‐ based approach from partial differential equation (PDE) perspective. The main differences from our previous works are two points: (a) the eigenvalues of the exosystem are not necessarily required to be algebraically simple; (b) tracking error feedback dynamic controls are designed directly from the uncertain PDE itself, not a nominal system where disturbance and reference are specially chosen so that the nominal waves and exosystem are detectable. To this purpose, we introduce transformations to transfer the original system into a disturbance free system, and at the same time, each reference is transformed into a linear combination of the exosystem. An observer is designed to estimate the states of the transformed disturbance free system and the unknown linear combinations of the exosystem. The feedforward controls are designed where the input disturbances are then written based on the linear combinations of the exosystem. A set of observer‐based feedback controls is then designed by replacing the state and disturbance with their estimates from the observer. The robustness of the closed‐loop system is discussed by analyzing the stability of the transformed tracking error system and the observer error system. The numerical simulations are presented to validate visually the effectiveness of the proposed tracking error feedback control.
Comparison of 2D and 3D meso‐model of concrete under high strain loading rate
Authors: Gupta P. K. , Singh Chandrabhan 
Published: June 2023

AbstractIn this paper, 2D and 3D meso‐models of concrete are developed numerically using different shapes of aggregate. For 2D model, circular and random polygon aggregate shapes are considered while for 3D model, spherical and convex hull aggregate shapes are adopted. Five different spatial distributions are employed in both circular and polygon shapes to get Circle1–Circle5 and Poly1–Poly5 geometrical model. Similarly, for 3D meso‐model, Spherical1–Spherical5 and one Convex hull geometrical models are developed. In all the numerical models, three different phases of concrete are considered, that is aggregate, mortar, and interfacial transition zone. Explicit analysis of the developed models has been performed using LS‐DYNA. All the developed models are verified by comparing the obtained results of stress–strain variations with the existing literature. The behavior of concrete is studied for both the loading conditions, that is quasi‐static and high strain loading rate. Added to this, the effect of spatial distribution of aggregates is also evaluated. Finally, the dynamic impact factors (DIF) are evaluated and compared for all the developed numerical models. Finally, cubic polynomial equations for DIF, for different shape aggregate 3D models, are obtained using regression analysis.
Effective nutrient removal using nutrient film technique hydroponics unit under varying nitrate nitrogen concentrations
Authors: Rajalakshmi Manimozhi , Manoj Valsa Remony 
Published: June 2023

AbstractSurface and groundwater are both susceptible to nitrate nitrogen contamination that has emerged as an issue around the globe in past few years. The main goal of this research was to treat nitrate‐contaminated water through phytoremediation in a hydroponic system with reduced cost and also assess the root and shoot growth of plants cultivated in NFT hydroponic systems. Four different nitrate‐nitrogen concentrations (30, 60, 90, and 120 mg/L) were given to hydroponic treatment unit. The results revealed that shoot growth, root growth, leaf number, and shoot numbers were increased with increasing nutrient solution concentration. The study's findings demonstrated that the average elimination efficiencies of nitrate‐nitrogen varied from 44.5% to 88% for money plants, 30.77% to 80.66% for crotons, 42.56% to 86% for arrowhead plants, 32.03% to 72.25% for vetiver grass, 28.08% to 70% for spinach, and 38.11% to 75.5% for brinjal plants, respectively. Thus, hydroponic phytoremediation has emerged as the environmental and cost‐effective technique for diminishing and removing nitrate nitrogen from wastewater.