bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive Vitamins and Epigenetic Modifications in Diabetes: A Perspective
Authors: Găman Mihnea-Alexandru , Cozma Elena-Codruța , Srichawla Bahadar S. , Cozma Matei-Alexandru , Kord Varkaneh Hamed , Chen Yongfeng , Găman Amelia Maria , Diaconu Camelia Cristina 
Published: April 2023

Abstract:
Diabetes is a complex metabolic disease that has been associated with epigenetic changes.
External factors such as dietary patterns can induce an imbalance in the pools of micronutrients
and macronutrients in the body. Consequently, bioactive vitamins may influence epigenetic mechanisms
via several pathways: involvement in the control of gene expression, and in protein synthesis,
by acting as coenzymes and co-factors in the metabolism of methyl groups or methylation of
DNA and histones. Herein, we present a perspective on the relevance of bioactive vitamins in the
epigenetic modifications that occur in diabetes.
Regulation of HIF-1 by MicroRNAs in Various Cardiovascular Diseases
Authors: Moradi Sarabi Mostafa , Tarhriz Vahideh , Abkhooie Leila 
Published: April 2023

Abstract:
Today, we see an increase in death due to cardiovascular diseases all over the world,
which has a lot to do with the regulation of oxygen homeostasis. Also, hypoxia-inducing factor 1
(HIF-1) is considered a vital factor in hypoxia and its physiological and pathological changes. HIF-
1 is involved in cellular activities, including proliferation, differentiation, and cell death in
endothelial cells (ECs) and cardiomyocytes. Similar to HIF-1α, which acts as a protective element
against various diseases in the cardiovascular system, the protective role of microRNAs (miRNAs)
has also been proved using animal models. The number of miRNAs identified in the regulation of
gene expression responsive to hypoxia and the importance of investigating the involvement of the
non-coding genome in cardiovascular diseases is increasing, which shows the issue's importance.
In this study, the molecular regulation of HIF-1 by miRNAs is considered to improve therapeutic
approaches in clinical diagnoses of cardiovascular diseases.
Sinularin Exerts Anti-cancer Effects by Inducing Oxidative Stress-mediated Ferroptosis,
Apoptosis, and Autophagy in Prostate Cancer Cells
Authors: Wu ZhengPing , Su MengQiao , Chen HanWu , Chen XuZhou , Chen Chung-Yi , An LiJie , Shao ZiChen , Liu XiaoYu , Lin Yi , OuYang Ai-Jun , Liu Chi-Ming 
Published: April 2023

Introduction::
Prostate cancer is the second-leading cause of cancer death in men. Sinularin is a soft coralsderived
natural compound that has anticancer activity in many cancer cells. However, the pharmacological action of
sinularin in prostate cancer is unclear.

Aim:
The aim of the study is to examine the anticancer effects of sinularin in prostate cancer cells.

Methods:
We explored the anticancer effects of sinularin on the prostate cancer cell lines, PC3, DU145, and LNCaP,
by MTT, Transwell assay, wound healing, flow cytometry, and western blotting.

Results:
Sinularin inhibited the cell viability and colony formation of these cancer cells. Furthermore, sinularin inhibited
testosterone-induced cell growth in LNCaP cells by downregulating the protein expression levels of androgen receptor
(AR), type II 5α-reductase, and prostate-specific antigen (PSA). Sinularin significantly attenuated the invasion and
migration ability of PC3 and DU145 cells, with or without TGF-β1 treatment. Sinularin inhibited epithelialmesenchymal
transition (EMT) in DU145 cells after 48 h of treatment by regulating the protein expression levels of Ecadherin,
N-cadherin, and vimentin. Sinularin induced apoptosis, autophagy, and ferroptosis by regulating the protein
expression levels of Beclin-1, LC3B, NRF2, GPX4, PARP, caspase-3, caspase-7, caspase-9, cleaved-PARP, Bcl-2, and
Bax. Moreover, intracellular reactive oxygen species (ROS) were increased but glutathione was decreased after sinularin
treatment in PC3, DU145 and LNCaP cells.

Conclusion:
Sinularin regulated the androgen receptor signaling pathway and triggered apoptosis, autophagy, and
ferroptosis in prostate cancer cells. In conclusion, the results indicated that sinularin may be a candidate agent for human
prostate cancer and need further study for being applied to human.
Review on Diabetic Complications and their Management by Flavonoids
and Triterpenoids
Authors: Shivam  , Gupta Asheesh Kumar , Kumar Sushil 
Published: April 2023

Abstract:
Diabetes mellitus, together with its numerous consequences, is rapidly becoming a major
health issue. Natural products are secondary metabolites found in plants that have a wide range of biological
functions. The development of anti-diabetic medications derived from natural compounds, particularly
those derived from plants having a documented folk-use history in the treatment of diabetes, is gaining
traction. Many studies have shown the usefulness of natural flavonoids with hypoglycemic properties in
the management of diabetic problems, along with their advantages. This paper describes the mechanisms
of action of several natural flavonoids whose hypoglycemic effects have been confirmed. Comprehensive
lifestyle treatments can help those at high risk of diabetes to avoid or delay the start of the disease, according
to the results of randomized controlled trials. Terpenoids are a type of natural substance that have
been identified as an anti-diabetic agent in various studies. Some of them are in various phases of preclinical
and clinical testing to conclude whether they can be used as anti-diabetic drugs. These compounds
can block the enzymes involved in insulin resistance, facilitate glucose metabolism, and positively affect
plasma glucose and insulin levels. By blocking multiple pathways implicated in diabetes and its consequences,
flavonoids and triterpenes can operate as potential agents in the treatment of diabetic retinopathy,
neuropathy, and nephropathy, as well as poor wound healing. However, there have been few attempts
to investigate the biological effects of triterpenes and clinical research investigating their use in the treatment
of diabetes. As a result, it is critical to pay close attention to these chemicals' therapeutic potential
and to contribute fresh information to the scientific community. This review focuses on current advancements
in flavonoids and triterpenes chemistry, derivatives, biological interventions, and therapeutic applications,
with a focus on diabetes and related illnesses.
Intracellular Compartmentalization: A Key Determinant of MicroRNA Functions
Authors: Nalavade Rohit , Singh Mohini 
Published: April 2023

Abstract:
Being an integral part of the eukaryotic transcriptome, miRNAs are regarded as vital regulators of diverse developmental and physiological processes. Clearly, miRNA activity is kept in check by various regulatory mechanisms that control their biogenesis and decay pathways. With the increasing technical depth of RNA profiling technologies, novel insights have unravelled the spatial diversity exhibited by miRNAs inside a cell. Compartmentalization of miRNAs adds complexity to the regulatory circuits of miRNA expression, thereby providing superior control over the miRNA function. This review provides a bird’s eye view of miRNAs expressed in different subcellular locations, thus affecting the gene regulatory pathways therein. Occurrence of miRNAs in diverse intra-cellular locales also reveals various unconventional roles played by miRNAs in different cellular organelles and expands the scope of miRNA functions beyond their traditionally known repressive activities.
Image Generation Method Based on Improved Generative Adversarial
Network
Authors: Zhang Huanjun 
Published: April 2023

Background:
The image generation model based on generative adversarial network
(GAN) has achieved remarkable achievements. However, traditional GAN has the disadvantage of
unstable training, which affects the quality of the generated image.

Objective:
This method is to solve the GAN image generation problems of poor image quality,
single image category, and slow model convergence.

Methods:
An improved image generation method is proposed based on GAN. Firstly, the attention
mechanism is introduced into the convolution layer of the generator and discriminator and a batch
normalization layer is added after each convolution layer. Secondly, the ReLU and leaky ReLU are
used as the active layer of the generator and discriminator, respectively. Thirdly, the transposed
convolution is used in the generator while the small step convolution is used in the discriminator,
respectively. Fourthly, a new discarding method is applied in the dropout layer.

Results:
The experiments were carried out on Caltech 101 dataset. The experimental results showed
that the image quality generated by the proposed method is better than that generated by GAN with
attention mechanism (AM-GAN) and GAN with stable training strategy (STS-GAN) and the stability
was improved.

Conclusion:
The proposed method is effectiveness for image generation with high quality.
Determinación anticipada de la vida útil del proyecto minero como esencial para la fijación de los límites temporales de la servidumbre legal minera y la cuantificación de las indemnizaciones a que tendrá derecho el propietario del predio sirviente
Authors: Guggiana Varela María Karina 
Published: April 2023

The mining easement is essentially temporary. It is delimited by virtue of the use made of the dominant property, so it is necessary that at the time of its constitution the useful life of the mining operation projected by the mining concessionary be determined in advance, thus allowing the identification of the temporary extension of the lien that is sought to be imposed on the servant property, as well as adequately quantify the damages that the owner of the latter will have the right to receive by way of compensation.
At present, serious adverse legal effects are generated to the interests of the owner of the servant property, since there are no legal norms that allow establishing the time limit at the time of constituting this type of easement, the transitory nature that is characteristic of them is distorted, mutating to an ineffable indeterminate extension of them, which also results in the non-specificity of the damages that must be compensated to the owner of the property.
Analysis Noise Level in Production the Palm Oil: A Case Study
Authors: Panjaitan Nismah , Panggabean Utari Noor Afifah 
Published: April 2023

Excessive noise exposure during the manufacturing process is a widespread issue. This research aimed to analyze noise exposure in the kernel recovery station in the manufacturing process of palm oil. We conduct some measurements and calculations for noise exposure analysis to get the Equivalent Noise Level (Leq) value during the daytime for each measurement point. The noise measurement was conducted on four machines, including a depericarper and polishing drum machine, ripple mill machine, silo dryer machine, and clay bath machine. In addition, this research showed noise contour mapping to define the noise distribution. The results of this research are that only the clay bath machine had Ls below the threshold. The clay bath machine workstation has good noise levels. The Depericarper, Polishing Drum, Ripple Mill, and Silo Dryer Machine must be quieter. Thus, this research used the Hierarchy of Control Approach to reduce and control hazardous noise exposure. The stage of HOC includes elimination, substitution, engineering, administrative control, and Personal Protective Equipment (PPE).
К ВОПРОСУ ИНТЕГРИРОВАНИЯ ПОЛНОЙ СИСТЕМЫ УРАВНЕНИЙ МАКСВЕЛЛА ДЛЯ СВЕТОВЫХ ВОЛН ОБЩЕЙ ПОЛЯРИЗАЦИИ РАСПРОСТРАНЯЮЩИХСЯ В НЕЛИНЕЙНОЙ ПЛЕНКЕ.
Authors: Г ОЧИРБАТ , О НЯМСҮРЭН 
Published: April 2023

Керр шугаман бус диэлектрик илтэс дотор тарах гэрлийн долгионы бодлогод Максвеллийн бүр систем тэгшитгэлийг интегралчлах нэгэн арга толилуу буй. Уг арга зохиогчийн олсон, нэг туслах функц тодорхойлох хоёрдугаар эрэмбийн дифференциал тэгшитгэл бодоход тулгуурлана.
Parameters extraction of photovoltaic cells using swarm intelligence based optimization technique: research on single diode model and double diode model
Authors: Ghoto Muhammad Imran , Balouch Mazhar Hussain , Jummani Touqeer Ahmed , Memon Ali Asghar 
Published: April 2023

Solar-energy is a clean source of energy and photovoltaic (PV) panels are constructed from solar cells (SC) which convert energy of light into electricity without any environmental effect. The researchers and policy makers focus on the huge scale adoption of solar panels due to its cleaner production. However, there is non-linear behavior in current-voltage characteristics of solar panels and shortage of data in manufacturer’s datasheet. In order to enhance the efficiency of solar panels it is mandatory to develop the PV panels scheme accurately by extracting the basic parameters. In this research study a mathematical model of two different solar cell models is used such as Single Diode Model (SDM) and Double Diode Model (DDM). The Particle Swarm Optimization (PSO) is used to extract the five and seven unknown parameters of SDM and DDM. The algorithm runs with one thousand iterations to minimize the Root Mean Square Error (RMSE) where the RMSE is the vector of five unknown parameters for SDM and seven for DDM. The superiority of proposed PSO algorithm is proved by the optimized results of unrevealed parameters with minimized RMSE of up to 10-3. Optimum parameter values for the solar cell models are applied on the real time data of a 55 mm diameter commercial RTC-France SC. Finally, the results reveal that P-V and I-V curves exhibit smallest deviation between estimated and real time values. The results reveal that the proposed PSO converges to optimal solution with least number of iterations compared to the existing metaheuristic algorithms.
THE LITERARY LEGACY OF KALLISTOS ANGELIKOUDES: AN ATTEMPT AT SYSTEMATIZATION
Authors: RODIONOV Oleg 
Published: April 2023

This article explores the little studied and partially unpublished literary corpus of Kallistos Angelikoudes, one of the most fascinating late Byzantine hesychast authors. It addresses some of the problems associated with the manuscript tradition of his writings and offers a new approach to the systematization of his oeuvre. Despite the uncertainty regarding the identification of the two groups of texts that make up the books of Angelikoudes’ literary corpus, that is, the Hesychastic Education and the Hesychastic Consolation, this article advances an argument with regard to the possible composition of these works.
The Role of Economic Empowerment Services at the Ministry of Social Development in Improving the Quality of Life for the Poor Palestinians in the Gaza Strip
Authors: Al-Arabid Ahmed Mohamed Saeed 
Published: April 2023

The study aimed to identify the role of economic empowerment services at the Ministry of Social Development to improve the quality of life for poor families in the Gaza Strip in the objective dimension (economic, social and health) and in the subjective dimension (adjustment, family compatibility and community integration), where the study was applied to the development directorates of the Ministry of Social Development on a random sample Simple Consisting of (363)single, and the researcher used a questionnaire tool to reach the results of the study, The study reached a number of results, the most important of which are: The contribution of empowerment services to improving the economic, social and health quality of life for families was medium, ranging from 48% to 55.0%. The results of the study also showed that economic empowerment services contributed to achieving adaptation, Compatibility and family independence, in addition to community integration, all of which came in medium rates, ranging from 48% to 63%. In light of the previous results, the current study recommends increasing the expansion of successful small development projects to help heads of families To reduce poverty, as well as to follow up the mechanisms of coordination and cooperation between governmental bodies and private bodies interested in economic empowerment and the development of the functional and administrative apparatus
Development of family resilience models†
Authors: Yang Min , Yang Shuang , Dela Rosa Ronnell D , Cui Lu-Hai 
Published: April 2023

Abstract
Family resilience is not the sum of the individual psychological resilience of each of the family members, but the family itself as a unit of resilience research. The representative models of family stress tolerance theory mainly include McCubbin’s series of family stress tolerance models and Walsh’s family stress tolerance framework, which are widely used in the practice of family therapy. In the future, empirical studies on family resilience should be strengthened, measurement tools with high reliability and validity should be established, and the combination of family resilience theory and community-based practice should be promoted.
Investigation of low-temperature plasmas formed in low-density gases surrounding laser-produced plasmas
Authors: Majszyk Mateusz , Bartnik Andrzej , Skrzeczanowski Wojciech , Fok Tomasz , Węgrzyński Łukasz , Szczurek Mirosław , Fiedorowicz Henryk 
Published: April 2023

Abstract
Low-temperature plasma production is possible as a result of photoionization using high-intensity extreme ultraviolet (EUV) and soft X-ray (SXR) pulses. Plasma of this type is also present in outer space, e.g., aurora borealis. It also occurs when high-velocity objects enter the atmosphere, during which period high temperatures can be produced locally by friction. Low-temperature plasma is also formed in an ambient gas surrounding the hot laser-produced plasma (LPP). In this work, a special system has been prepared for investigation of this type of plasma. The LPP was created inside a chamber filled with a gas under a low pressure, of the order of 1–50 mbar, by a laser pulse (3–9 J, 1–8 ns) focused onto a gas puff target. In such a case, the SXR/EUV radiation emitted from the LPP was partially absorbed in the low-density gas. In this case, high- and low-temperature plasmas (T
e ~100 eV and ~1 eV, respectively) were created locally in the chamber. Investigation of the EUV-induced plasmas was performed mainly using spectral methods in ultraviolet/visible (UV/VIS) light. The measurements were performed using an echelle spectrometer, and additionally, spatial–temporal measurements were performed using an optical streak camera. Spectral analysis was supported by the PGOPHER numerical code.
Using microwave refraction to determine local inhomogeneities of a rotating plasma
Authors: Martseniuk Yurii P. , Siusko Yevhen V. , Kovtun Yurii V. 
Published: April 2023

Abstract
To determine the local inhomogeneities of a rotating plasma, the method based on microwave refraction was used. The method is based on spectral and correlation analysis of the reflected signals from the rotating plasma layer at normal and inclined microwave incidence. This method allowed us to determine local inhomogeneities of plasma electron density, angles of azimuthal displacement of grooves, and its angular frequency of rotation. Using an additional 4th horn antenna, in contrast to previous works, it was possible to find and analyze two regions with azimuthal inhomogeneities in the rotating plasma. Analysis of the reflected signals shows the presence of four grooves, and the angular frequency of rotation ω = 1.16 × 104 rad/s was also determined.
Kinetic energy partitions in electron–ion PIC simulations of ABC fields
Authors: Chen Qiang 
Published: April 2023

Abstract
We explore the kinetic energy partitions between electrons and ions in the 2-D magnetostatic equilibria called Arnold–Beltrami–Childress (ABC) fields, using particle-in-cell (PIC) numerical simulations. We cover a wider range of ion–electron temperature combinations and get different results compared to previous studies of the Harris-layer-type magnetic reconnection simulations. We find that the initial ion–electron enthalpy ratio is an important indicator. The particle species that dominates the total enthalpy will also dominate the kinetic energy gains and the momentum distribution peaks, but the other species have higher nonthermal energy fractions because both species show similar maximum energies.
‘Sympathy for the Devil?’ McDonald’s between imperialism and the building of post-Yugoslav Serbian identity
Authors: Tournois Laurent 
Published: April 2023

Abstract
Since the opening of its first restaurant in a communist country, which was Yugoslavia, not only is the huge success of the U.S. franchise something that was merely not supposed to happen, but ‘consuming McDonald’s’ has left its mark on the post ‑Yugoslav identity building process. Our central argument is that the singularity of the ‘McDonaldization of Serbia’ encompasses the interactions between expansion/ localness, dominance/adaptation and those who take part in this historical process which spans more than three decades, their responses that apprise, shape and constrain their everyday life conditions. This paper starts from the observation that most of the existing scholarly literature on identity building addresses the end of the Yugoslav experience whether through state narratives or identities introverted. We chose a different and understudied angle, which is a people ‑centred perspective. Accordingly, this paper uses different research methods under the umbrella of a biographical perspective from 1988 to 2021. Ethnographic fieldwork, comprising 45 semi ‑structured interviews with Belgradians, aims to expand scholarly knowledge on consumption and identity building in post ‑Yugoslav Serbia. In addition, conversations with influential individuals contributed to identify periods in the intermingled life of McDonald’s and people in contemporary Serbia. In the early 1990s, the McDonaldisation to some extent escalated cultural disputes between the republics against a backdrop of identity tensions. During the period spanning from the late years of Milosevic’s rule to the advent of Alexandar Vučić in 2012, political conflicts over sovereignty sparked ambiguous civic responses. Finally, McDonald’s has brought Serbs into the Western sphere which is probably best encapsulated in a local popular saying ‘McDonald’s is McDonald’s’ (‘Mek je Mek’), despite being considered ‘tasty’/unhealthy, expensive/rewarding or socially stimulating.
SENSITIVITY PATTERN OF E. COLI ISOLATED FROM CLOACA OF LAYING HENS WITH DIARRHEA AGAINTS STREPTOMISIN, KANAMISIN AND DOKSISIKLIN
Authors: Dwipayana I Made Adhi Kusuma , Gelgel Ketut Tono Pasek , Suarjana I Gusti Ketut 
Published: April 2023

The aim of this study was to determine the sensitivity of E. coli bacteria isolated from cloacal swabs of laying hens with diarrhea to streptomycin, kanamycin and doxycycline. A total of 16 samples were used from farms in the villages of Utu (Tabanan), Perean (Tabanan), Demulih (Bangli) and Pasedahan (Karangasem). The sensitivity test of E. coli bacteria used the disc diffusion method from Kirby Bauer. Data analysis was carried out descriptively with the cross tabulation method. The results of 16 isolates of E. coli which were divided into 4 age groups isolated from laying hens cloacal swabs showed a pattern of sensitivity to streptomycin 62.5% resistant, 18.75% intermediates and 18.75% sensitive. The pattern of sensitivity to kanamycin showed an intermediate 6.25% and the sensitivity result was 93.75%. To doxycycline resistance 50%, intermediate 18.75% and sensitive 31.25%. There is an increase in E coli resistance to streptomycin at >4 months of age, while doxycycline at 2-4 months of age and increasing at >4 months of age.