bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical simulation of pressure relief stress distribution of diamond beaded rope saw cutting in low permeability coal seam
Authors: Wang Wei , Wang Xiaochuan , LI Hongchao , Hu Jincheng , Zhang Tianyi , Xu Chaoyu 
Published: September 2023

AbstractThe diamond bead slit is a practical method for changing the stress distribution of low permeability coal seam and achieving pressure relief and reflection improvement. The stress distribution of coal seam in large scale is not clear due to the influence of diamond bead slit parameters and geological parameters, making it difficult to identify. In this paper, the finite element model with built-in Coulomb friction contact surface is used to simulate the stress distribution in coal with different angles, seam length, working face length, seam friction coefficient and different in-situ stress difference. This investigation is conducted to examine the stress distribution of parallel working face, vertical coal seam, and advance working face. The simulation results show that the mechanism of stress transfer in large scale diamond beaded rope saw cutting coal seam is mainly due to the tangential slip of coal body on both sides of seam surface, forming concentrative zone and pressure relief zone with axial distribution, center symmetry and phase. The pressure relief range and maximum pressure relief range of all three direction present a "single peak" distribution with the change of angel α between slit and maximum in-situ stress, i.e. when α = 45°, both of them are maximum. The slit length mainly affects the stress distribution in the advancing direction of the working face, and the length of working face mainly affects the stress distribution in the direction of parallel working face and vertical coal seam, both of which are positively correlated with the pressure relief range and the maximum pressure relief amplitude. The friction coefficient of seam surface and the difference of in-situ stress affect the relative dislocation of coal body on both sides of seam surface, and they inhibit and promote the pressure relief range and the maximum pressure relief amplitude respectively, and are greatly affected by α. The simulation results above suggest that it is reasonable to select fracture and geological parameters in practical engineering.
Evolving Trends and Burden of Inflammatory Bowel Disease in Asia, 1990–2019: A Comprehensive Analysis Based on the Global Burden of Disease Study
Authors: Chen Xuejie , Xiang Xin , Xia Weitong , Li Xindi , Wang Sidan , Ye Shuyu , Tian Li , Zhao Lian , Ai Feiyan , Shen Zhaohua , Nie Kai , Deng Minzi , Wang Xiaoyan 
Published: September 2023

Abstract
Background
Asia’s inflammatory bowel disease (IBD) burden has rapidly increased recently, but the epidemiological trends in Asia remain unclear. We report IBD’s incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALY) in 52 Asian countries from 1990 to 2019.

Methods
Data from the Global Burden of Disease 2019 were analyzed for IBD burden across 52 countries, using metrics like incidence, prevalence, mortality rates, and DALY. The epidemiological trend of IBD from 1990 to 2019 was assessed with the Joinpoint and APC methods. Decomposition and frontier analyses examined factors behind IBD case and death changes. The NORPRED forecasted Asia's morbidity and mortality trends from 2019 to 2044.

Results
From 1990 to 2019, The incidence and prevalence of IBD increased in Asia, while mortality and DALY decreased. East Asia had the highest increase in disease burden. IBD incidence was highest among the 30–34 age group, with prevalence peaking in the 45–49 age group. In high-income regions, IBD peak age shifted to younger groups. Decompose analysis showed population growth as the primary factor for the increasing IBD cases in Asia. NORDPRED model predicted a continued IBD burden increase in Asia over the next 25 years.

Conclusions
Between 1990 and 2019, ASIR and ASPR of IBD in Asia increased, while ASMR and ASDR decreased. Due to population growth and aging, the IBD burden is expected to rise over the next 25 years, particularly in East Asia.
Major Incident Hospital Simulations in Hospital Based Health Care: A Scoping Review
Authors: Wynter Sacha , Nash Rosie , Gadd Nicola 
Published: September 2023

AbstractMajor incidents are occurring in increasing frequency, and place significant stress on existing health-care systems. Simulation is often used to evaluate and improve the capacity of health systems to respond to these incidents, although this is difficult to evaluate. A scoping review was performed, searching 2 databases (PubMed, CINAHL) following PRISMA guidelines. The eligibility criteria included studies addressing whole hospital simulation, published in English after 2000, and interventional or observational research. Exclusion criteria included studies limited to single departments or prehospital conditions, pure computer modelling and dissimilar health systems to Australia. After exclusions, 11 relevant studies were included. These studies assessed various types of simulation, from tabletop exercises to multihospital events, with various outcome measures. The studies were highly heterogenous and assessed as representing variable levels of evidence. In general, all articles had positive conclusions with respect to the use of major incidence simulations. Several benefits were identified, and areas of improvement for the future were highlighted. Benefits included improved understanding of existing Major Incident Response Plans and familiarity with the necessary paradigm shifts of resource management in such events. However, overall this scoping review was unable to make definitive conclusions due to a low level of evidence and lack of validated evaluation.
AN IMPROVEMENT TO A THEOREM OF LEONETTI AND LUCA
Authors: DANH TRAN NGUYEN THANH , DUNG HOANG TUAN , HUNG PHAM VIET , KIEN NGUYEN DINH , THINH NGUYEN AN , TOAN KHUC DINH , THO NGUYEN XUAN 
Published: September 2023

AbstractLeonetti and Luca [‘On the iterates of the shifted Euler’s function’, Bull. Aust. Math. Soc., to appear] have shown that the integer sequence
$(x_n)_{n\geq 1}$
defined by
$x_{n+2}=\phi (x_{n+1})+\phi (x_{n})+k$
, where
$x_1,x_2\geq 1$
,
$k\geq 0$
and
$2 \mid k$
, is bounded by
$4^{X^{3^{k+1}}}$
, where
$X=(3x_1+5x_2+7k)/2$
. We improve this result by showing that the sequence
$(x_n)$
is bounded by
$2^{2X^2+X-3}$
, where
$X=x_1+x_2+2k$
.
Leucocytozoon cariamae n. sp. and Haemoproteus pulcher coinfection in Cariama cristata (Aves: Cariamiformes): first mitochondrial genome analysis and morphological description of a leucocytozoid in Brazil
Authors: Vieira Lis Marques de C. , Pereira Pedro Henrique O. , Vilela Daniel Ambrózio da Rocha , Landau Irène , Pacheco M. Andreína , Escalante Ananias A. , Ferreira Francisco C. , Braga Érika Martins 
Published: September 2023

AbstractThe distribution of avian haemosporidians of the genus Leucocytozoon in the Neotropics remains poorly understood. Recent studies confirmed their presence in the region using molecular techniques alone, but evidence for gametocytes and data on putative competent hosts for Leucocytozoon are still lacking outside highland areas. We combined morphological and molecular data to characterize a new Leucocytozoon species infecting a non-migratory red-legged seriema (Cariama cristata), the first report of a competent host for Leucocytozoon in Brazil. Leucocytozoon cariamae n. sp. is distinguished from the Leucocytozoon fringillinarum group by its microgametocytes that are not strongly appressed to the host cell nucleus. The bird studied was coinfected with Haemoproteus pulcher, and we present a Bayesian phylogenetic analysis based on nearly complete mitochondrial genomes of these 2 parasites. Leucocytozoon cariamae n. sp. morphology is consistent with our phylogenetic analysis indicating that it does not share a recent common ancestor with the L. fringillinarum group. Haemoproteus pulcher and Haemoproteus catharti form a monophyletic group with Haemocystidium parasites of Reptilia, supporting the polyphyly of the genus Haemoproteus. We also discussed the hypothesis that H. pulcher and H. catharti may be avian Haemocystidium, highlighting the need to study non-passerine parasites to untangle the systematics of Haemosporida.
Reconfiguring essential and discretionary public goods
Authors: Bieber Friedemann , de Jongh Maurits 
Published: September 2023

AbstractWhen is state coercion for the provision of public goods justified? And how should the social surplus of public goods be distributed? Philosophers approach these questions by distinguishing between essential and discretionary public goods. This article explains the intractability of this distinction, and presents two upshots. First, if governments provide configurations of public goods that simultaneously serve essential and discretionary purposes, the scope for justifiable complaints by honest holdouts is narrower than commonly assumed. Second, however, claims to distributive fairness in the provision of public goods also turn out to be more complex to assess.
El Niño oscillations impact anti-predator defences to alter survival of an herbivorous beetle in a neotropical wet forest
Authors: Vencl Fredric V. , Srygley Robert B. 
Published: September 2023

Abstract
Little is known about the effects of El Niño-Southern Oscillation (ENSO) on tropical insect communities, even though they are suffering rapid declines in complexity and stability due to climate change. We explore the impact of fluctuations in local climate imposed by ENSO on the performance of herbivore defences mediating enemy interactions. In a widespread rainforest edge community, we quantified the mortality caused by five enemy guilds on the immature stages of the herbivorous beetle, Acromis sparsa. ENSO was a significant determinant of beetle mortality. During warmer, drier El Niño years, the survival of beetles decreased. This was due to increased egg parasitism by wasps, which reduced hatching. Additionally, ant predation on beetle larvae increased. Flies and wasps were in competition for larval prey in wetter, cooler La Niña years. Experimental removal of maternal guards or chemical shields revealed which ENSO-related parameters predicted larval mortality. Guarding was most effective against social wasps in La Niña, whereas shields proved most effective in El Niño. Two ENSO-related defence–enemy breakdowns occurred: (1) decoupling whereby the efficacy of a narrow defensive adaptation was reduced to increase mortality, and (2) mismatching whereby the resistance of a narrow defensive adaptation against non-targeted enemies was further reduced to increase mortality. These results highlight that defence efficacy against natural enemies can vary predictably with biotic and abiotic environmental conditions. ENSO events will increase breakdowns in defence-mediated interactions, shifts in competition among enemies, and species loss.
Obeticholic acid treatment of mice to promote fertilization and reproduction
Authors: Liang Ming , Yang Huailiang , Xu Lanyong , Cao Longqiao 
Published: September 2023

SummaryObeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, has been demonstrated to ameliorate the histopathological characteristics of liver damage. Nonetheless, the systemic safety profile of OCA with regard to reproduction and development remains poorly understood. In the present study, we conducted a dose–response experiment by administering OCA at doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg through tube feeding to investigate its effect on reproductive development and fertilization rate in both male and female mice. Furthermore, we evaluated the levels of protein and mitochondrial function in the placenta through western blot, qPCR, and scanning electron microscopy. The results showed that 10 mg/kg and 20 mg/kg OCA doses significantly reduced the rate of placental implantation (P < 0.05). Also, OCA increased maternal body weight. In addition, OCA increased levels of FXR and TGR5 and produced changes in oxidative stress levels (P < 0.05). Mitochondrial activity result found that 10 mg/kg and 20 mg/kg of OCA significantly reduced the mitophagy autosomes/nucleus compared with the normal control group (P < 0.05). What is more, there was no significant difference in sperm count after OCA intervention in either C57BL/10 mice or BALB/c mice. Overall, we demonstrated that OCA treatment protected against placental implantation by suppressing placental oxidative stress and mitochondrial activity.
Changes on depression and suicidal ideation under severe lockdown restrictions during the first wave of the COVID-19 pandemic in Spain: a longitudinal study in the general population
Authors: Ayuso-Mateos J. L. , Morillo D. , Haro J. M. , Olaya B. , Lara E. , Miret M. 
Published: September 2023

AbstractAimsTo assess whether there is a change in the prevalence of depression and suicidal ideation after the strict lockdown measures due to the first wave of the COVID-19 pandemic in Spain, and to assess which are the factors associated with the incidence of a depressive episode or suicidal ideation during the lockdown.MethodsData from a longitudinal adult population-based cohort from Madrid and Barcelona were analysed (n = 1103). Face-to-face home-based (pre-pandemic) and telephone interviews were performed. Depression and suicidal ideation were assessed through an adaptation of the Composite International Diagnostic Interview (CIDI 3.0). Population prevalence estimates and multivariable logistic regressions were computed.ResultsPrevalence rates of depression changed significantly from before to after the COVID-19 outbreak (from 3.06% to 12.00%;p = 0.01) and per sex and age groups. Individuals reporting COVID-19 concerns (odds ratio [OR] = 3.11; 95% confidence interval [CI] = 1.45–6.69) and those feeling loneliness (OR = 1.99; 95% CI = 1.52–2.61) during the lockdown were at increased risk of developing depression during the confinement. Resilience showed a protective effect against the risk of depression (OR = 0.57; 95% CI = 0.39–0.83), while individuals perceiving social support during the confinement were at lower risk of developing suicidal thoughts (OR = 0.21; 95% CI = 0.09–0.46). Greater disability during the lockdown was also associated with the risk of suicidal ideation (OR = 2.77; 95% CI = 1.53–5.03).ConclusionsContinuous reinforcement of mental health preventive and intervening measures is of global importance, particularly among vulnerable groups who are experiencing the most distress. Future research should strive to evaluate the long-term effects of the COVID-19 crisis on mental health.
Early Spontaneous Twinning Recorded By Time-Lapse
Authors: Matorras Roberto , Vendrell Alberto , Ferrando Marcos , Larreategui Zaloa 
Published: September 2023

AbstractMonozygotic twins (MZT) are 2.5 times more frequent in ART than in natural conceptions. A number of ART-related mechanisms have been probably linked with MZT. Studies that retrospectively analyze the time-lapse (TL) records resulting in MZT suggest that some morphokinetic traits of the inner cell mass and the trophectoderm could be predictors of MZT, but results are controversial. We present the complete TL record of one case of MZT that split itself at the very moment of the division into two cells, with one of the cells coming out through a hole in the zona pellucida (ZP). Both resulting embryos developed normally, and were vitrified. It is suggested that the hole in the ZP may facilitate the extrusion of some cells of the <day 4 embryo and that this cell development is not constrained by being inside the ZP. Despite the lack of the inhibition of the ZP itself or the influence of the other embryo cells, the totipotent cell was then able to develop correctly from the start. Moreover, the embryo inside the ZP compensated for the loss of this cell apparently without problems. Our findings are discussed in the context of previous literature and ethical problems are addressed.
Fracture Network Characterization in Reservoirs by Joint Inversion of Microseismicity and Thermal Breakthrough Data: Method Development and Verification
Authors: Jiang Zhenjiao , Ringel Lisa Maria , Bayer Peter , Xu Tianfu 
Published: September 2023

AbstractThe spatial configuration of fractures often regulates flow and transport in the subsurface. However, the characterization of fracture networks is a challenging task, especially in deep reservoirs, because here only a limited number of boreholes is available to perform downhole logs and cross‐well hydraulic and tracer tests. In this study, we develop a joint inversion procedure to infer fracture number, geometry, and aperture based on Bayesian principles, utilizing microseismic (MS) events and thermal breakthrough data; both are typically available in enhanced geothermal systems and unconventional gas/oil reservoirs. A basic discrete fracture geometry, including orientations, lengths and positions of fractures, is generated from an MS events cloud by minimizing the distance between fractures and MS events. This geometric configuration, together with the aperture, is then further adjusted, based on the reversible jump Markov chain Monte Carlo algorithm, to minimize the misfit between observed and calculated thermal breakthrough curves by iterative forward flow and heat transport modeling. The inversion model is applied to two synthetic test cases. Following the sensitivity analysis of temperatures to fracture parameters, and the robustness analysis on the model performance under supportive data featuring good and poor quality, it is confirmed that the probabilistic joint inversion procedure approximates the fracture geometry and aperture well, and errors in predicting temperatures based on realizations of fracture networks are well below 5%. The methodology provides a new way to characterize fracture networks in the subsurface, without restrictions on predetermined fracture sizes or the number of fractures.
Pancreatic β-cell mitophagy as an adaptive response to metabolic stress and the underlying mechanism that involves lysosomal Ca2+ release
Authors: Oh Soo-Jin , Park Kihyoun , Sonn Seong Keun , Oh Goo Taeg , Lee Myung-Shik 
Published: September 2023

AbstractMitophagy is an excellent example of selective autophagy that eliminates damaged or dysfunctional mitochondria, and it is crucial for the maintenance of mitochondrial integrity and function. The critical roles of autophagy in pancreatic β-cell structure and function have been clearly shown. Furthermore, morphological abnormalities and decreased function of mitochondria have been observed in autophagy-deficient β-cells, suggesting the importance of β-cell mitophagy. However, the role of authentic mitophagy in β-cell function has not been clearly demonstrated, as mice with pancreatic β-cell-specific disruption of Parkin, one of the most important players in mitophagy, did not exhibit apparent abnormalities in β-cell function or glucose homeostasis. Instead, the role of mitophagy in pancreatic β-cells has been investigated using β-cell-specific Tfeb-knockout mice (TfebΔβ-cell mice); Tfeb is a master regulator of lysosomal biogenesis or autophagy gene expression and participates in mitophagy. TfebΔβ-cell mice were unable to adaptively increase mitophagy or mitochondrial complex activity in response to high-fat diet (HFD)-induced metabolic stress. Consequently, TfebΔβ-cell mice exhibited impaired β-cell responses and further exacerbated metabolic deterioration after HFD feeding. TFEB was activated by mitochondrial or metabolic stress-induced lysosomal Ca2+ release, which led to calcineurin activation and mitophagy. After lysosomal Ca2+ release, depleted lysosomal Ca2+ stores were replenished by ER Ca2+ through ER→lysosomal Ca2+ refilling, which supplemented the low lysosomal Ca2+ capacity. The importance of mitophagy in β-cell function was also demonstrated in mice that developed β-cell dysfunction and glucose intolerance after treatment with a calcineurin inhibitor that hampered TFEB activation and mitophagy.
The stress-responsive protein REDD1 and its pathophysiological functions
Authors: Kim Ji-Yoon , Kwon Young-Guen , Kim Young-Myeong 
Published: September 2023

AbstractRegulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein that controls various cellular functions, including metabolism, oxidative stress, autophagy, and cell fate, and contributes to the pathogenesis of metabolic and inflammatory disorders, neurodegeneration, and cancer. REDD1 usually exerts deleterious effects, including tumorigenesis, metabolic inflammation, neurodegeneration, and muscle dystrophy; however, it also exhibits protective functions by regulating multiple intrinsic cell activities through either an mTORC1-dependent or -independent mechanism. REDD1 typically regulates mTORC1 signaling, NF-κB activation, and cellular pro-oxidant or antioxidant activity by interacting with 14-3-3 proteins, IκBα, and thioredoxin-interacting protein or 75 kDa glucose-regulated protein, respectively. The diverse functions of REDD1 depend on cell type, cellular context, interaction partners, and cellular localization (e.g., mitochondria, endomembrane, or cytosol). Therefore, comprehensively understanding the molecular mechanisms and biological roles of REDD1 under pathophysiological conditions is of utmost importance. In this review, based on the published literature, we highlight and discuss the molecular mechanisms underlying the REDD1 expression and its actions, biological functions, and pathophysiological roles.
Lipid remodeling of adipose tissue in metabolic health and disease
Authors: Cho Yoon Keun , Lee Sumin , Lee Jaewon , Doh Junsang , Park Joo-Hong , Jung Young-Suk , Lee Yun-Hee 
Published: September 2023

Abstract
Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in energy homeostasis and endocrine function. Recent advancements in lipidomics techniques have enabled the study of the complex lipid composition of adipose tissue and its role in metabolic disorders such as obesity, diabetes, and cardiovascular disease. In addition, adipose tissue lipidomics has emerged as a powerful tool for understanding the molecular mechanisms underlying these disorders and identifying bioactive lipid mediators and potential therapeutic targets. This review aims to summarize recent lipidomics studies that investigated the dynamic remodeling of adipose tissue lipids in response to specific physiological changes, pharmacological interventions, and pathological conditions. We discuss the molecular mechanisms of lipid remodeling in adipose tissue and explore the recent identification of bioactive lipid mediators generated in adipose tissue that regulate adipocytes and systemic metabolism. We propose that manipulating lipid-mediator metabolism could serve as a therapeutic approach for preventing or treating obesity-related metabolic diseases.