bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtuelle Inbetriebnahme in der Maschinenautomatisierung
Authors: Siegrist Daniel , Matsikis Alexandros , Dirbach Simon , Volz Artur , Bellalouna Fahmi 
Published: April 2023

Basierend auf der erfolgreichen Nutzung von Simulationsmethoden wie HIL, SIL, und MIL in unterschiedlichen Industriezweigen, werden Simulationsmethoden zunehmend interessanter für die virtuelle Inbetriebnahme in der Maschinenautomatisierung. Dieser Artikel stellt die Methoden vor und beschreibt mögliche Anwendungsfelder in der Maschinenautomatisierung. Des Weiteren wird ein vereinfachtes Auswahlverfahren basierend auf der Anwendung während der Phasen des Maschinenlebenszyklus vorgeschlagen. Anschließend wird der Einsatz von SEW-Komponenten mit einer hybriden Methode mit Schwerpunkt auf HIL anhand einer beispielhaften Demonstrationsmaschine untersucht und bestätigt.
Biointelligente Produktionssysteme
Authors: Miehe Robert , Baumgarten Yannick , Shoshi Arber 
Published: April 2023

Mit der biointelligenten Produktion wird eine nachhaltige Wertschöpfung möglich. Dies erfordert sowohl die Entwicklung technologischer Innovationen, die mit dem Konzept der Biointelligenz vereinbar sind, als auch die Entwicklung von Strukturen und Rahmenbedingungen, die die nachhaltige Nutzung solcher Systeme ermöglichen. In diesem Beitrag werden die Grundlagen der Biointelligenz erläutert und entsprechende Technologien sowie ein möglicher Rahmen für eine biointelligente Produktion vorgestellt. Abschließend werden die Herausforderungen der biointelligenten Produktion beschrieben.
Laboratory studies of seismic wave propagation in inhomogeneous media using a laser doppler vibrometer
Authors: Nishizawa Osamu , Satoh Takashi , Lei Xinglin , Kuwahara Yasuto 
Published: April 2023

AbstractWe performed physical model experiments by utilizing a laser doppler vibrometer (LDV). Because LDV converts velocity of vibration to the Doppler shift frequency, it enables very precise measurements of ultrasonic waves without any resonating element that conventional transducers usually include. A piezoelectric transducer (PZT) was used as a source of elastic waves, and the waveform was measured in a very small area of about 400 μm in diameter by focusing the beam. We can easily perform very precise measurements of wave field in a physical model, and thus physical model experiments of wave propagation can simulate realistic seismic field observations. For models of inhomogeneous material, we used three granitic rocks with different grain sizes: Westerly granite (fine grained), Oshima granite (medium grained), and Inada granite (coarse grained). Large rock prisms, 300 × 300 × 80 to 90 mm, were used to prevent contamination by multiple reflections from the side ends in the earlier portion of waveforms. The direct P and S waves and reflected waves were identified by their travel times. Observations were made by long in-line, circular, and small-aperture arrays. When the rock grain size becomes comparable to the wavelength, transmitted waves are strongly attenuated by backward scattering, and a large amount of wave energy is transferred to the coda portion. Semblance plots in the time-slowness plane obtained from the small-aperture array suggest that incoherent waves become dominant as the grain size becomes large and comparable to the wavelength.
The 1978 Brooks Peninsula, Vancouver Island earthquakes
Authors: Spindler Chris , Rogers Garry C. , Cassidy John F. 
Published: April 2023

AbstractA pair of Mw = 5.5 earthquakes occurred beneath the Brooks Peninsula on the northwest coast of Vancouver Island on 2 June and 25 July 1978. These are the largest and best-recorded earthquakes to date in the vicinity of northern Vancouver Island and the adjacent coast margin. A detailed study of these earthquakes was undertaken to examine the contemporary tectonics of this region, specifically the poorly understood interaction between the Explorer plate and the North American plate at the northern end of the Cascadia subduction zone. Both earthquakes were followed by well-defined aftershock sequences. A four-station temporary seismograph array deployed on the Brooks Peninsula following the 2 June mainshock allowed for accurate aftershock locations. This earthquake was located at 50.15° N, 127.84° W, based on the center of a 9-km-diameter circular region of aftershocks. The 25 July earthquake was located 4 to 7 km to the northeast of the June epicenter based on waveform comparison of the two events. Both earthquakes occurred at 15 to 16 km depth. The focal mechanisms as determined from body-wave modeling are nearly identical and show left-lateral strike-slip motion along a shallow north-dipping, east-west-striking fault. The focal mechanism and depth of these two earthquakes indicates that they were not megathrust events on the Explorer/North America plate boundary, but rather that they occurred within the North American plate, 5 to 10 km above the megathrust. The northeast-directed pressure axes for these earthquakes suggests coupling across the Explorer-North America segment of the Cascadia subduction zone, consistent with contemporary convergence of the Explorer Plate with the North American plate in a northeast-southwest direction.
Application of InP/ZnSe/ZnS Quantum Dots in the Treatment of Experimental Antibiotic-Resistant Endophthalmitis <i>in vivo</i>
Authors: Ponomarev V. O. , Kazaykin V. N. , Tkachenko K. A. , Vokhmintsev A. S. , Weinstein I. A. , Zhdanov A. E. 
Published: April 2023

Purpose: modeling of experimental antibiotic-resistant endophthalmitis on laboratory animals model describing the interaction of quantum dots and a biological organism and its physicochemical and kinetic aspects.Material and methods. The object of the study is laboratory New Zealand rabbits (2 male, age 4 months, weight 3.5 kg). The inflammation inductor is the culture of Methicillin-Resistant Staphylococcus Aureus (MRSA). 1 mg/0.05 ml of vancomycin in combination with 0.5 μg (0.01 %)/0.05 ml by a solution of quantum dots InP/ZnSe/ZnS 660 was intravitreally administrated to the first rabbit. 1 mg/0.1 ml of vancomycin was intravitreally administrated to the second rabbit. Dynamic observation of the clinical process was performed daily by photo registration of the front segment and ultrasonic sonography.Results. The conjugate based on 1 mg/0.05 ml vancomycin coupled with 0.5 μg (0.01 %)/0.05 ml quantum dots InP/ZnSe/ZnS 660 demonstrated high anti-infectious activity against vancomycin-resistant MRSA. It was shown that the effect of the above solution on MRSA is described by the one-time ability of quantum dots by using electron microscopy. The presence of superoxide radicals O2–• generation in an aqueous solution of quantum dots under the action of blue light has also been proven by spectrophotometric method.Conclusion. Conjugates based on quantum dots can be considered as one of the promising directions of treatment of antibiotic-resistant endophthalmitis.
Clinico-epidemiologic profile and perinatal outcome of patients with oligohydramnios in third trimester in a tertiary care hospital
Authors: Bumrah Sunaina , Grover Seema , Kaur Khushpreet , Rajora Parveen , Tapasvi Isha 
Published: April 2023

Background: Oligohydramnios has an incidence of around 1-5% of total pregnancies. It is associated with adverse perinatal outcomes like preterm delivery, low birth weight, foetal distress, and passage of meconium and NICU admission. Aims and objectives were to study the risk factors associated with oligohydramnios in pregnancy and to evaluate the perinatal outcome in patients with oligohydramnios.
Methods: The present study was a prospective observational study of six months, which included 60 patients with gestational age >28 weeks, selected after verifying the inclusion and exclusion criteria. A detailed history and clinical examination done and relevant investigations sent. Patients were followed up postpartum till discharge from hospital.
Results: The prevalence of oligohydramnios is found to be 8.5% in our study and there were more primigravida (55%). Oligohydramnios was idiopathic in 50% of our patients, followed by presence of hypertensive disorders in 20%. Caesarean delivery was required in 48.3% of the patients. In terms of perinatal outcome, 46.6% of the babies were low birth weight, 38.3% preterm, NICU admission in 26.6% and stillbirth rate was found to be 6.6%.
Conclusions: Oligohydramnios was an isolated finding in half of the cases and in these only adverse perinatal outcome noted was small for gestational age. When associated with risk factors, oligohydramnios was associated with increased perinatal morbidity and mortality in terms of prematurity, foetal distress, low birth weight, NICU admission, stillbirth.
A study unveiling online buying behavior of zoomers with respect to Mumbai region
Authors: Binani Rishika , Kapadia Priyam , Agashivala Sachi , Vasa Vatsal , Ved Anjali 
Published: April 2023

Generation Z has emerged as one of the most mystifying consumers as they are tech-savvy, global, visual, social, technologically active, digitally connected and educated users of technologies in the marketplace. Gen Z is made up of young people who are born between 1997-2010. Our definition of acronym Gen Zhereby explains the entire mindset of zoomers."Googling" before purchasing: Gen Z tends to research products and read reviews online before making a purchase.Embracing e-commerce: Gen Z has grown up with the convenience of online shopping and tends to prefer it over traditional brick-and-mortar stores. Non-traditional payment methods: Gen Z is more likely to use mobile payments and other digital payment methods, such as Google pay, Paytm or PayPal, instead of cash or credit cards. Zero tolerance for bad user experiences: Gen Z expects a seamless, user-friendly online shopping experience, and will quickly abandon a website or app if it doesn't meet their expectations.This research intends to study online buying behavior of the most important and the youngest generation. It is extremely significant and valuable to study this segment of society as this is the generation who started operating mobile phones even before knowing- How to eat?The research undertaken intends to understand the impact of COVID which has increased the frequency of online transactions on the face of safety back end by indolence.
Capitalismo. Competencia, conflicto y crisis, de Anwar Shaikh
Authors: Martínez Hernández Francisco A. , Isidro Luna Víctor M. 
Published: April 2023

Reseña bibliográfica de Capitalismo: Competencia, conflicto y crisis por Anwar Shaikh. El autor estudia en este libro y de forma empírica y teórica la ganancia, la competencia real a través de la reducción de costos, ciclos cortos y largos, y la distinción de regularidades en variables económicas importantes. Shaikh usa una metodología clásica basada en Smith, Ricardo, Marx y Harrod. Se da un panorama general del libro, después se resume cada capítulo y finalmente se recomienda la manera en que el libro pudiera ser leído.
THE RELATIONSHIP BETWEEN ANXIETY AND BRUXISM IN ADULTS
Authors: Amalia Rizki , Arifin Rahmad , Dwinta Sari Galuh 
Published: April 2023

ABSTRACTBackground: Anxiety disorder is a psychological condition that includes worry, anxiety, and restlessness. The prevalence of emotional anxiety disorders in Indonesia is 9.9%, anxiety can cause somatic symptoms causing irritability, muscle tension and restlessness which results in the appearance of parafunctional oral activities such as bruxism. Bruxism is a bad habit of grinding and clenching teeth excessively inadvertently which involves the activity of the masticatory muscles, resulting in clinical problems in the involved teeth, such as attrition, tooth fracture, and increased sensitivity and degree of tooth mobility, exostosis and torus of the jawbone, hypertrophy of the masticatory muscles, periodontal tissue damage, and causes headaches and temporomandibular joint damage Purpose: The purpose of the literature study was to determine the relationship between anxiety and bruxism in adults Material and Methods: All reviewed articles were obtained from searching Google Scholar, Pubmed and Science Direct data sources which have a maximum journal publication time of 10 years. Results: The review was conducted in 22 journals that were responding with the inclusion criteria such as journals available in the form of full text in Indonesian or English, the subjects of the journal were people who have an adult age suffering from anxiety and bruxism. Conclusion: there is a relation between anxiety and bruxism in adult.Keywords: Adult, Anxiety, Bruxism.
THE IMMERSION EFFECT OF 50% KASTURI (Mangifera casturi) LEAF EXTRACT ON COLOR CHANGES OF THERMOPLASTIC NYLON DENTURE BASE
Authors: Rusyida Dinda Nur , Arifin Rahmad , Ichrom Nahzi Muhammad Yanuar 
Published: April 2023

ABSTRACTBackground: The most commonly used denture cleanser is alkaline peroxide. Long-term use of alkaline peroxide caused color change on denture base. One of which can be used as an alternative ingredient is kasturi leaf (Mangifera casturi). 50% kasturi leaf extract has antifungal properties against candida albicans. 50% kasturi leaf extract can be used as an alternative natural denture cleanser. Purpose: To know the immersion effect in 50% kasturi leaf extract on color changes of thermoplastic nylon. Methods: This study was true experimental with pretest dan posttest with control group design. 24 samples used simple random sampling with 8 samples in each groups. The sample is round sized 20mm in diameter and 3mm thickness. The treatment divided into 3 group, 50% leaf extract as treatment group, alkaline peroxide as positive control group, dan aquadest as negative control group. The color change was measured before and after immersion for five days using digital analysis tools with CIELab system. Results: One Way ANOVA dan Post Hoc Bonferroni statistical test showed significant differences (p<0,05) between the immersion groups in 50% kasturi leaf extract (6,25 ± 1,90), alkaline peroxide (4,00 ± 0,99), and aquadest (2,19 ± 0,71). Conclusion: The 50% kasturi leaf extract has effect on color changes of thermoplastic nylon denture base. The color changes in 50% kasturi leaf extract is higher than alkaline peroxide and aquadest. Keywords : Color changes, Kasturi leaf, Thermoplastic nylon
ANTIBACTERIAL ACTIVITY OF RAMBAI LEAF EXTRACT (Sonneratia caseolaris) CONCENTRATION 25% 50% 75% AND 100% AGAINST BACTERIA Enterococcus faecalis
Authors: Ramadilla US Ramadilla , Aspriyanto Didit , Diana Sherli 
Published: April 2023

ABSTRACTBackground: The causative factor of failure in the treatment of the root canal is the presence of microorganisms, namely the bacterium Enterococcus faecalis. Rambai leaf extract (Sonneratia caseolaris) also contains secondary metabolite compounds, namely, triterpenoids, phenols, tannins, steroids, and flavonoids that are able to inhibit the growth of Enterococcus faecalis bacteria which have the potential to cause failure in root canal treatment. Purpose: This research has a purpose to see the antibacterial activity of Rambai leaf extract (Sonneratia caseolaris) concentrations of 25%, 50%, 75%, and 100% against Enterococcus faecalis bacteria. Method: This study is a true experimental study designed by Posttest Only with Control Group Design using six. Material and methods: Rambai leaf extract concentrations of 25%, 50%, 75%, 100%, positive control of chlorhexidine gluconate 2%, and negative control of aqua dest was repeated 4 times. Antibacterial activity can be seen from the magnitude of the inhibitory zone formed in (MHA) Mueller Hinton Agar and BHIB (Brain Heart Infusion) using the diffusion method. Results: Based on Mann Whitney's final test, there was a significant difference in the clear zones formed around the paper disk. The average clear zone of Rambai leaf extract (Sonneratia caseolaris) concentration is 25% at 10.0mm, 50% at 12.7mm, 75% at 17.0mm, and 100% at 18.3mm. Conclusion: There is activity of Rambai leaf extract (Sonneratia caseolaris) concentrations of 25%, 50%, 75%, and 100% against Enterococcus faecalis bacteria. Keywords: Antibacterial Activity, Enterococcus faecalis, Rambai Leaf Extract
THE EFFECT OF GLYCERIN APPLICATION ON SURFACE HARDNESS OF NANOHYBRID COMPOSITE RESIN IMMERSED IN ALCOHOLIC MOUTHWASH
Authors: Nugroho Tio Aldi , Fortuna Gloria , Batubara Lusiana , Hardini Nadia 
Published: April 2023

ABSTRACT Background: Composite resin is the most commonly used restorative material. One of properties composite resins is surface hardness can change due to exposure of the restorative material to oral fluids such as alcoholic mouthwash. The degradation that occurs due to alcoholic mouthwash is able to reduce the surface hardness of the nanohybrid composite resin. Glycerin is able to increase the hardness of the composite resin by perfecting the polymerization that occurs in the restorative material when exposed to light cured light. Objectives: This study aims to determine the effect of glycerin application on the hardness of nanohybrid composite resins after immersion in alcoholic mouthwash. Methods: A total of 32 samples of nanohobride composite resin in this study were made in the form of a cylinder with a diameter of 5 mm and a thickness of 2 mm. The nanohybrid composite resin samples were divided into control and treatment group by applying glycerin on the sample surface before light curing. The study was continued by immersing the sample into artificial saliva for 24 hours and alcoholic mouthwash for 6 hours. The research continued with surface hardness test using the Vickers Hardness Tester. Result : Paired bivariate T test showed a significant difference between the two groups (p<0.005). The conclusions of this study indicate that the application of glycerin has an effect on the hardness of the nanohybrid composite resin after immersion with alcoholic mouthwash. Conclusion: The application of glycerin affects the hardness of the nanohybrid composite resin after immersion with alcoholic mouthwash. Key words: Glycerin application, Hardness, Nanohybrid composite resin
MULTIDISCIPLINARY APPROACH OF IMPACTED PERMANENT MAXILLARY LEFT CENTRAL INCISOR AND CANINE
Authors: Puspitasari Yustisia , Sjamsudin Jusuf 
Published: April 2023

ABSTRACT Background: The permanent maxillary canines have significant incidence of impaction, being the most affected teeth after the third molars, while impacted maxillary insicor is the third most commonly impacted tooth. Objective: This case report is about a multidisclipinary orthodontic treatment of 12 years old female with chief complaint of unerupted anterior upper teeth. Case: A case with unerupted of permanent maxillary left central incisor tooth and permanent maxillary left canine tooth, with Angle Class 1 molar relation and crowded of mandibular teeth. Panoramic and occlusal radiograph showed impacted 21 tooth with severely root dilacerations and impacted 23 tooth in palatal and horizontal position. Case Management: The patient was treated with Edgewise technique. Surgical approach was applied 3 months after levelling and unravelling stage to extract 21 tooth due to its severely root dilaceration and to bond lingual button on palatal side of 23 tooth. Orthodontic traction of impacted 23 tooth was applied a week after being exposed to the position of 21 tooth. Thirteen months after traction, 23 tooth was totally erupted and need 8 additional months to reach its final position. The crown of 23 was reshaped with porcelain fused to metal crown and 63 tooth was left still and got conservative treatment with composite. Conclusion: Orthodontic traction and reshaping of impacted 23 tooth was succeeded to replace the position of 21 tooth with good occlusion and esthetic. Based on OPG after treatment, all teeth were in good root paralleling. The patient was satisfied with good occlusion and esthetic. Keywords: Impacted maxillary canine, Impacted maxillary incisor, Root dilaceration, Orthodontic treatment, Surgical exposure
Metagenomics and Machine Learning-Based Precision Medicine Approaches for Autoimmune Diseases
Authors: Zehrh Itrat , Habiba Umme , Picco Matilde Rosalia , Basheer Sidra Hafiza , Rehman Umer Abdul , Haider Owaisa , Khoso Shahzaib 
Published: April 2023

The makeup of human microbiota has been linked to a number of autoimmune disorders. Recent developments in whole metagenome sequencing and 16S rRNA sequencing technology have considerably aided research into the microbiome and its relationship to disease. Due to the inherent high dimensionality and complexity of data generated by high-throughput platforms, conventional bioinformatics techniques could only provide an inadequate explanation for the most relevant changes and seldom provide correct predictions. Machine learning, on the other hand, is a subset of artificial intelligence applications that enable the untangling of high-dimensional systems and intricate knots in correlation by learning complex patterns and improving automatically from training data without being explicitly programmed. Machine learning is increasingly being utilized to research the influence of microbes on the onset of illness and other clinical features since computer power has increased dramatically in the last few decades. In this review paper, we focused on emerging methodological approaches of supervised machine learning algorithms for identification of autoimmune disorders utilizing metagenomics data, as well as the potential benefits and limitations of machine learning models in clinical applications.
Tumor-restrictive type III collagen in the breast cancer microenvironment: prognostic and therapeutic implications
Authors: Volk Susan , Brisson Becky , Dekky Bassil , Berger Ashton , Mauldin Elizabeth , Loebel Claudia , Yen William , Stewart Daniel , Gillette Deborah , Assenmacher Charles-Antoine , Cukierman Edna , Burdick Jason , Borges Virginia 
Published: April 2023

Abstract

Collagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor-permissive and -restrictive collagen matrices are critical to improve prognostication and develop more effective therapeutic strategies. In this study, using a combination of in vitro, in vivo and in silico experiments, we show that type III collagen (Col3) plays a tumor-restrictive role in human breast cancer. We demonstrate that Col3-deficient, human fibroblasts produce tumor-permissive collagen matrices that drive cell proliferation and suppress apoptosis in noninvasive and invasive breast cancer cell lines. In human TNBC biopsy samples, we demonstrate elevated deposition of Col3 relative to type I collagen (Col1) in noninvasive compared to invasive regions. Similarly, in silico analyses of over 1000 breast cancer patient biopsies from The Cancer Genome Atlas BRCA cohort revealed that patients with higher Col3:Col1 bulk tumor expression had improved overall, disease-free and progression-free survival relative to those with higher Col1:Col3 expression. Using an established 3D culture model, we show that Col3 increases spheroid formation and induces formation of lumen-like structures that resemble non-neoplastic mammary acini. Finally, our in vivo study shows co-injection of murine breast cancer cells (4T1) with rhCol3-supplemented hydrogels limits tumor growth and decreases pulmonary metastatic burden compared to controls. Taken together, these data collectively support a tumor-suppressive role for Col3 in human breast cancer and suggest that strategies that increase Col3 may provide a safe and effective modality to limit recurrence in breast cancer patients.