bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of polypharmacy on plasma bepridil concentration in patients with heart failure: a multicenter retrospective study
Authors: Asai Yuki , Arihara Hiroki , Omote Saki , Tanio Ena , Yamashita Saena , Higuchi Takashi , Hashimoto Ei , Yamada Momoko , Tsuji Hinako , Kondo Yoshihiro , Hayashi Makoto , Yamamoto Yoshiaki 
Published: March 2023

Abstract
Background
Polypharmacy, defined as the concurrent use of over six drugs, is common in the treatment of heart failure (HF); however, unpredictable drug interactions with bepridil may occur. In this study, we have elucidated the influence of polypharmacy on plasma bepridil concentrations in patients with HF.

Methods
We conducted a multicenter retrospective study involving 359 adult patients with HF who received oral bepridil. Because QT prolongation is an adverse effect following plasma bepridil concentrations ≥800 ng/mL, the risk factors for patients achieving these concentrations at steady state were elucidated via multivariate logistic regression. The correlation between bepridil dose and plasma concentration was examined. The effect of polypharmacy on the value of the concentration-to-dose (C/D) ratio was investigated.

Results
A significant relationship was observed between bepridil dose and plasma concentration (p <  0.001), and the intensity of the correlation was moderate (r = 0.503). Based on multivariate logistic regression, the adjusted odds ratios for a daily dose of bepridil ≥1.6 mg/kg, polypharmacy, and concomitant of aprindine, a cytochrome P450 2D6 inhibitor, were 6.82 (95% coefficient interval: 2.104–22.132, p = 0.001), 2.96 (95% coefficient interval: 1.014–8.643, p = 0.047), and 8.63 (95% coefficient interval: 1.684–44.215, p = 0.010), respectively. Despite the moderate correlation in non-polypharmacy, the correlation was not observed in polypharmacy. Therefore, inhibiting metabolism, along with other mechanisms, may contribute to the polypharmacy-induced increase in plasma bepridil concentrations. Moreover, the C/D ratios in the groups receiving 6–9 and 10≤ concomitant drugs were 1.28- and 1.70-fold higher than in those receiving <6 drugs, respectively.

Conclusions
Plasma bepridil concentrations may be influenced by polypharmacy. Moreover, the plasma bepridil concentration increased in correlation with the number of concomitant drugs used. Although the mechanism of this increase could not be determined, plasma bepridil concentrations should be periodically monitored for safe use in patients with HF.

Trial registration
Retrospectively registered.
The predictive power of Bitcoin prices for the realized volatility of US stock sector returns
Authors: Bouri Elie , Salisu Afees A. , Gupta Rangan 
Published: March 2023

AbstractThis paper is motivated by Bitcoin’s rapid ascension into mainstream finance and recent evidence of a strong relationship between Bitcoin and US stock markets. It is also motivated by a lack of empirical studies on whether Bitcoin prices contain useful information for the volatility of US stock returns, particularly at the sectoral level of data. We specifically assess Bitcoin prices’ ability to predict the volatility of US composite and sectoral stock indices using both in-sample and out-of-sample analyses over multiple forecast horizons, based on daily data from November 22, 2017, to December, 30, 2021. The findings show that Bitcoin prices have significant predictive power for US stock volatility, with an inverse relationship between Bitcoin prices and stock sector volatility. Regardless of the stock sectors or number of forecast horizons, the model that includes Bitcoin prices consistently outperforms the benchmark historical average model. These findings are independent of the volatility measure used. Using Bitcoin prices as a predictor yields higher economic gains. These findings emphasize the importance and utility of tracking Bitcoin prices when forecasting the volatility of US stock sectors, which is important for practitioners and policymakers.
Variant femoral nerve: the path beneath the iliacus muscle and into neuropathic symptoms
Authors: Vinson Colby , Pavlovsky Ethan , Loomis Mario 
Published: March 2023

Abstract
Background
Previous discussions regarding variant femoral nerves often report an aberrant slip of a small portion of the iliacus muscle as a common cause of the femoral nerve splitting. Within these reported cases, the variant path involves a small amount of the nerve and treatment often involves surgical intervention to relieve nerve entrapment. Only a few cases have been reported that were not secondary to an aberrant muscle slippage, none of which include the variant discussed below.

Case presentation
A Caucasian male cadaver in his 70 s was discovered to have a variant femoral nerve upon dissection and evaluation of the pelvic region, without evidence of muscle slippage or surgical intervention. The bulk of the nerve pierced and traveled deep within the iliacus muscle before emerging distal to the pubic eminence and merging with the smaller portion that continued with the native course anteriorly. This variation would result in a predisposition to nerve compression during hip flexion and knee extension, with subsequent patient concerns of muscle weakness and sensory loss of unknown origins.

Conclusion
Awareness of this atypical variation could provide clinicians with another potential diagnosis to consider when managing femoral neuropathy, as well as the rationale for a noninvasive treatment option.
Blood levels of brain-derived neurotrophic factor (BDNF) in systemic lupus erythematous (SLE): a systematic review and meta-analysis
Authors: Shobeiri Parnian , Maleki Saba , Amanollahi Mobina , Habibzadeh Amirhossein , Teixeira Antonio L. , Rezaei Nima 
Published: March 2023

Abstract
Objectives
BDNF has been implicated in the pathophysiology of systemic lupus erythematosus (SLE), especially its neuropsychiatric symptoms. The purpose of this study was to investigate the profile of blood BDNF levels in patients with SLE.

Methods
We searched PubMed, EMBASE, and the Cochrane Library for papers that compared BDNF levels in SLE patients and healthy controls (HCs). The Newcastle–Ottawa scale was used to assess the quality of the included publications, and statistical analyses were carried out using R 4.0.4.

Results
The final analysis included eight studies totaling 323 healthy controls and 658 SLE patients. Meta-analysis did not show statistically significant differences in blood BDNF concentrations in SLE patients compared to HCs (SMD 0.08, 95% CI [ − 1.15; 1.32], P value = 0.89). After removing outliers, there was no significant change in the results: SMD -0.3868 (95% CI [ − 1.17; 0.39], P value = 0.33. Univariate meta-regression analysis revealed that sample size, number of males, NOS score, and mean age of the SLE participants accounted for the heterogeneity of the studies (R2 were 26.89%, 16.53%, 18.8%, and 49.96%, respectively).

Conclusion
In conclusion, our meta-analysis found no significant association between blood BDNF levels and SLE. The potential role and relevance of BDNF in SLE need to be further examined in higher quality studies.
Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS)
Authors: Rappuoli Rino , Young Paul , Ron Eliora , Pecetta Simone , Pizza Mariagrazia 
Published: March 2023

AbstractOur planet is populated by at least a trillion species of microorganisms. Every life form is sustained by them and they make the planet habitable. Only a minority of them, about 1400 species, cause infectious diseases that are responsible for human morbidity, mortality, pandemics and the resulting huge economic losses. Modern human activities, environmental changes and the attempt to control infectious agents using broad spectrum antibiotics and disinfectants jeopardize the global microbial diversity. The International Union of the Microbiological Societies (IUMS) is launching a call to action to mobilize all microbiological societies globally to promote the development of sustainable solutions to control infectious agents while preserving the global microbial diversity and the healthy life of our planet.
Mutual interaction of lncRNAs and epigenetics: focusing on cancer
Authors: Ranjbar Maryam , Heydarzadeh Samaneh , Shekari Khaniani Mahmoud , Foruzandeh Zahra , Seif Farhad , Pornour Majid , Rahmanpour Dara , Tarhriz Vahideh , Alivand MohammadReza 
Published: March 2023

AbstractLong noncoding RNAs are characterized as noncoding transcripts longer than 200 nucleotides in response to a variety of functions within the cells. They are involved in almost all cellular mechanisms so as epigenetics. Given that epigenetics is an important phenomenon, which participates in the biology of complex diseases, many valuable studies have been performed to demonstrate the control status of lncRNAs and epigenetics. DNA methylation and histone modifications as epigenetic mechanisms can regulate the expression of lncRNAs by affecting their coding genes. Reciprocally, the three-dimensional structure of lncRNAs could mechanistically control the activity of epigenetic-related enzymes. Dysregulation in the mutual interaction between epigenetics and lncRNAs is one of the hallmarks of cancer. These mechanisms are either directly or indirectly involved in various cancer properties such as proliferation, apoptosis, invasion, and metastasis. For instance, lncRNA HOTAIR plays a role in regulating the expression of many genes by interacting with epigenetic factors such as DNA methyltransferases and EZH2, and thus plays a role in the initiation and progression of various cancers. Conversely, the expression of this lncRNA is also controlled by epigenetic factors. Therefore, focusing on this reciprocated interaction can apply to cancer management and the identification of prognostic, diagnostic, and druggable targets. In the current review, we discuss the reciprocal relationship between lncRNAs and epigenetic mechanisms to promote or prevent cancer progression and find new potent biomarkers and targets for cancer diagnosis and therapy.
The effect of spinal magnetic stimulation on the management of functional constipation in adults
Authors: Fawaz Shereen Ismail , Elshatby Nehad Mohamed , El-Tawab Sarah Sayed 
Published: March 2023

AbstractBackgroundFunctional constipation is a type of functional bowel disorder characterized by difficult defecation with a sense of incomplete evacuation. It is a common disorder with an increasing prevalence, and the underlying cause is poorly identified. Nonpharmacological management of functional constipation includes lifestyle and dietary modification, regular physical activity, advice about toileting posture, and behavioral therapy. Biofeedback training as part of the behavioral training showed great efficacy with long-term results. Spinal magnetic stimulation is the application of extracorporeal magnetic stimuli to the spinal nerves and deep pelvic muscles to enhance bowel evacuation without surgical drawbacks. This study was designed to enhance bowel elimination in functional constipation patients through the dual effect of biofeedback and spinal magnetic stimulation. This work aimed to study the efficacy of spinal magnetic stimulation and biofeedback training versus biofeedback alone in the management of functional constipation.ResultsThere was a statistically significant difference between before and after the intervention in both studied groups regarding the mean weekly spontaneous bowel movement, a Numerical Rating Scale for pain assessment, and the Patient Assessment of Constipation Quality of Life questionnaire. When comparing the two groups after the intervention, the spinal magnetic stimulation showed superiority in the mean weekly spontaneous bowel movement and manometric anal pressure at rest.ConclusionsSpinal magnetic stimulation in addition to biofeedback pelvic floor muscle training could increase the mean weekly complete spontaneous bowel movements and manometric anal pressure at rest in patients with functional constipation. It did not show any additive benefits in improving pain during defecation or patient quality of life.Trial registrationClinicalTrials.gov, 0305398. https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000BQ0H&selectaction=Edit&uid=U0004JW0&ts=2&cx=-xmnims
Bearing failure diagnosis and prognostics modeling in plants for industrial purpose
Authors: Omoregbee Henry Ogbemudia , Edward Bright Aghogho , Olanipekun Mabel Usunobun 
Published: March 2023

AbstractWhen condition-based maintenance (CBM) is combined with proper decision support systems, it leads to enhanced utilization of resources and increased productivity which tends towards business efficiency. The forecasting of the future condition, the remaining operating life, or probability of stable system behavior, based on data from acquired condition monitoring is referred to as prognosis which is an important part of the CBM process. Despite auto-regression integrated moving average (ARIMA) time series modeling, being long established and dating back to the 1960s, it has surged through new advances over the years and is now recognized as a major forecasting technique. Its application is therefore investigated here in the context of the FEMTO–ST Institute (Franche-Comté Électronique Mécanique Thermique et Optique-Sciences et Technologies) bearing dataset. The work discussed in this article uses a time series approach which contributes to modeling and forecasting the remaining useful life (RUL) of bearings in plants, thereby helping to prevent catastrophic failure before it occurs. The motivation for this paper lies in the approach used in structuring the ARIMA models, thereby adding value in its application by first ensuring the stationarity of the time series signal by using the Dickey-Fuller Test, which then makes forecasting easy and accurate. The result obtained here using ARIMA is compared to the results obtained in the literature where neural network regression (NNR) was used as part of the FEMTO competition. We checked by contrasting our observations with the NNR observations obtained as well as the experimental results from the National Aeronautics and Space Administration (NASA)
Mobile applications in the Philippines during the COVID-19 pandemic: systematic search, use case mapping, and quality assessment using the Mobile App Rating Scale (MARS)
Authors: Gonzales Aldren , Custodio Razel , Lapitan Marie Carmela , Ladia Mary Ann 
Published: March 2023

AbstractBackgroundIn the Philippines, various mobile health apps were implemented during the COVID-19 pandemic with very little knowledge in terms of their quality. The aims of this paper were 1) to systemically search for mobile apps with COVID-19 pandemic use case that are implemented in the Philippines; 2) to assess the apps using Mobile App Rating Scale (MARS); and 3) to identify the critical points for future improvements of these apps.MethodsTo identify existing mobile applications with COVID-19 pandemic use case employed in the Philippines, Google Play and Apple App Stores were systematically searched. Further search was conducted using the Google Search. Data were extracted from the app web store profile and apps were categorized according to use cases. Mobile apps that met the inclusion criteria were independently assessed and scored by two researchers using the MARS—a 23-item, expert-based rating scale for assessing the quality of mHealth applications.ResultsA total of 27 apps were identified and assessed using MARS. The majority of the apps are designed for managing exposure to COVID-19 and for promoting health monitoring. The overall MARS score of all the apps is 3.62 points (SD 0.7), with a maximum score of 4.7 for an app used for telehealth and a minimum of 2.3 for a COVID-19 health declaration app. The majority (n = 19, 70%) of the apps are equal to or exceeded the minimum “acceptable” MARS score of 3.0. Looking at the categories, the apps for raising awareness received the highest MARS score of 4.58 (SD 0.03) while those designed for managing exposure to COVID-19 received the lowest mean score of 3.06 (SD 0.6).ConclusionsThere is a heterogenous quality of mHealth apps implemented during the COVID-19 pandemic in the Philippines. The study also identified areas to better improve the tools. Considering that mHealth is expected to be an integral part of the healthcare system post-pandemic, the results warrant better policies and guidance in the development and implementation to ensure quality across the board and as a result, positively impact health outcomes.
Evaluation of a Pathway team for homeless mental health in-patients
Authors: Tulloch Alex D. , Khan Zana , Hewett Nigel , Koehne Sophie , Rao Ranga 
Published: March 2023

Aims and methodThe Pathway model is an enhanced care coordination model for homeless people in hospital. We aimed to evaluate the first attempt to apply it on psychiatric wards, which started in 2015 in South London. We developed a logic model which expressed how the Pathway approach might work. Two predictions from this model were tested, using propensity scores and regression to estimate the effect of the intervention among people who were eligible for it.ResultsThe Pathway team theorised that their interventions would reduce length of stay, improve housing outcomes and optimise the use of primary care – and, more tentatively, reduce readmission and emergency presentations. We were able to estimate effects on length of stay (−20.3 days; 95% CI −32.5 to −8.1; P = 0.0012) and readmission (a non-significant reduction).Clinical implicationsThe marked reduction in length of stay, explicable in terms of the logic model, constitutes preliminary support for the Pathway model in mental health services.
Work-related experiences of consultant psychiatrists during the COVID-19 response: qualitative analysis
Authors: O'Donnell Shane , Quigley Etain , Hayden John , Adamis Dimitrios , Gavin Blánaid , McNicholas Fiona 
Published: March 2023

Background
Research has begun to draw attention to the challenges mental health professionals faced in delivering services during the COVID-19 pandemic response. However, few studies have examined the specific experiences of consultant psychiatrists.

Aims
To examine the work-related experiences and psychosocial needs of consultant psychiatrists situated in the Republic of Ireland arising from the COVID-19 response.

Method
We interviewed 18 consultant psychiatrists and analysed data using inductive thematic analysis.

Results
Work-related experience of participants was characterised by increased workload associated with assumption of guardianship of physical and mental health of vulnerable patients. Unintended consequences of public health restrictions increased case complexity, limited availability of alternative supports and hindered the practice of psychiatry, including inhibiting peer support systems for psychiatrists. Participants perceived available psychological supports as generally unsuitable for their needs given their specialty. Long-standing under-resourcing, mistrust in management and high levels of burnout exacerbated the psychological burden of the COVID-19 response.

Conclusions
The challenges of leading mental health services were evident in the increased complexity involved in caring for vulnerable patients during the pandemic, contributing to uncertainty, loss of control and moral distress among participants. These dynamics worked synergistically with pre-existing system-level failures, eroding capacity to mount an effective response. The longer-term psychological well-being of consultant psychiatrists – as well as the pandemic preparedness of healthcare systems – is contingent on implementation of policies addressing long-standing under-investment in the services vulnerable populations rely on, not least community mental health services.
Zebrafish cutaneous injury models reveal that Langerhans cells engulf axonal debris in adult epidermis
Authors: Peterman Eric , Quitevis Elgene J. A. , Black Erik C. , Horton Emma C. , Aelmore Rune L. , White Ethan , Sagasti Alvaro , Rasmussen Jeffrey P. 
Published: March 2023

ABSTRACT
Somatosensory neurons extend enormous peripheral axons to the skin, where they detect diverse environmental stimuli. Somatosensory peripheral axons are easily damaged due to their small caliber and superficial location. Axonal damage results in Wallerian degeneration, creating vast quantities of cellular debris that phagocytes must remove to maintain organ homeostasis. The cellular mechanisms that ensure efficient clearance of axon debris from stratified adult skin are unknown. Here, we established zebrafish scales as a tractable model to study axon degeneration in the adult epidermis. Using this system, we demonstrated that skin-resident immune cells known as Langerhans cells engulf the majority of axon debris. In contrast to immature skin, adult keratinocytes did not significantly contribute to debris removal, even in animals lacking Langerhans cells. Our study establishes a powerful new model for studying Wallerian degeneration and identifies a new function for Langerhans cells in maintenance of adult skin homeostasis following injury. These findings have important implications for pathologies that trigger somatosensory axon degeneration.
Acromioclavicular Joint Injuries in Sport
Authors: Kelley Naomi , Tuttle Matthew , Sylvia Stephen M. , Dragoo Jason L. , Khodaee Morteza 
Published: March 2023

AbstractSport-related shoulder injuries, including disruptions to the acromioclavicular joint (ACJ), are common. An ACJ injury is classified by the degree and direction of the clavicle displacement. Although the diagnosis can be made clinically, standard radiographic views are important to determine the severity of the ACJ disruption and assess for concurrent injuries. The majority of ACJ injuries can be managed nonoperatively; however, surgical treatment is indicated in some cases. Long-term outcomes are generally favorable for most ACJ injuries, and athletes generally return to sport without functional limitations. This article provides an in-depth discussion regarding all aspects of ACJ injuries, including clinically relevant anatomy, biomechanics, evaluation, treatment, and complications.