bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of filler aspect ratio in the reinforcement of an epoxy resin with graphene nanoplatelets
Authors: Guest James , Kinloch Ian A. , Young Robert J. 
Published: June 2023

AbstractThe mechanisms of reinforcement of an epoxy resin by the addition of graphene nanoplatelets (GNPs) has been studied in detail. It is found that the addition of GNPs increases both the stiffness and fracture toughness of the epoxy resin. The dependence of the flexural modulus upon the volume fraction of the GNPs has been modelled using a combination of the rule of mixtures and shear lag analysis and it is shown that the reinforcement is controlled principally by the aspect ratio (length/thickness) of the GNPs. The dependence of the fracture energy upon the GNP volume fraction has been modelled assuming failure takes place through the debonding of the GNP particles followed by their pull-out and it is again shown that the aspect ratio of the GNPs is a vital parameter in controlling the level of toughening. It is found that the behaviour can be modelled using a similar value of GNP aspect ratio to model both the flexural stiffness and fracture behaviour, demonstrating the importance of this parameter in controlling the mechanical properties of GNP/epoxy resin nanocomposites.

Graphical abstract
Optimizing the seeded CVD-growth of uniform graphene films on silicon
Authors: Yan Zhichen , Wang Shuangyue , Chen Xianjue , Poduval Geedhika K. , Stride John A. 
Published: June 2023

AbstractChemical vapor deposition (CVD) has great potential to produce graphene films at large-scale. However, CVD production of graphene films usually requires a catalytic metal substrate, such as copper. Recently we have developed a new method to grow graphene films directly on crystalline silicon wafers with a thermally grown 300 nm oxide layer, using a seeded-CVD growth approach. The use of methane as the feedstock and optimized graphene seeds has led to enhanced film formation, which SEM, X-ray photo-electron and Raman spectroscopies indicate consist of graphene layers formed by the coalescence of expanding “graphene seeds”. The resultant films have regions of single graphene crystallites within them as a result of lateral growth of the seeds. In addition, we have observed that the unilateral conductivity of the graphene films is consistent with the presence of graphene nanoribbons and as such has potential application in device fabrication.
New Dominant-Negative IL6ST Variants Expand the Immunological and Clinical Spectrum of GP130-Dependent Hyper-IgE Syndrome
Authors: Arlabosse Tiphaine , Materna Marie , Riccio Orbicia , Schnider Caroline , Angelini Federica , Perreau Matthieu , Rochat Isabelle , Superti-Furga Andrea , Campos-Xavier Belinda , Héritier Sébastien , Pereira Anaïs , Deswarte Caroline , Lévy Romain , Distefano Marco , Bustamante Jacinta , Roelens Marie , Borie Raphaël , Le Brun Mathilde , Crestani Bruno , Casanova Jean-Laurent , Puel Anne , Hofer Michaël , Fieschi Claire , Theodoropoulou Katerina , Béziat Vivien , Candotti Fabio 
Published: June 2023

AbstractPatients with autosomal dominant (AD) hyper-IgE syndrome (HIES) suffer from a constellation of manifestations including recurrent bacterial and fungal infections, severe atopy, and skeletal abnormalities. This condition is typically caused by monoallelic dominant-negative (DN) STAT3 variants. In 2020, we described 12 patients from eight kindreds with DN IL6ST variants resulting in a new form of AD HIES. These variants encoded truncated GP130 receptors, with intact extracellular and transmembrane domains, but lacking the intracellular recycling motif and the four STAT3-binding residues, resulting in an inability to recycle and activate STAT3. We report here two new DN variants of IL6ST in three unrelated families with HIES-AD. The biochemical and clinical impacts of these variants are different from those of the previously reported variants. The p.(Ser731Valfs*8) variant, identified in seven patients from two families, lacks the recycling motif and all the STAT3-binding residues, but its levels on the cell surface are only slightly increased and it underlies mild biological phenotypes with variable clinical expressivity. The p.(Arg768*) variant, identified in a single patient, lacks the recycling motif and the three most distal STAT3-binding residues. This variant accumulates at the cell surface and underlies severe biological and clinical phenotypes. The p.(Ser731Valfs*8) variant shows that a DN GP130 expressed at near normal levels on the cell surface can underlie heterogeneous clinical presentations, ranging from mild to severe. The p.(Arg768*) variant demonstrates that a truncated GP130 protein retaining one STAT3-binding residue can underlie severe HIES.
Burst Phase Analysis of the Aggregation Prone α-synuclein Amyloid Protein
Authors: Saraiva Marco A. , Florêncio M. Helena 
Published: June 2023

AbstractWhile some studies inferred that valid information can be retrieved for the refolding of proteins and consequent identification of folding intermediates in the stopped-flow spectrometry collapse phase, other studies report that these burst phase folding intermediates can be questioned, implying a solvent-dependent modification of the still unfolded polypeptide chain. We therefore decided to investigate the burst phase occurring for the α-synuclein (Syn) amyloid protein by stopped-flow spectrometry. Solvent-dependent modification effects indeed occurred for the Nα-acetyl-L-tyrosinamide (NAYA) parent small compound and for the folded monomeric ubiquitin protein. More complex was the burst phase analysis of the disordered Syn amyloid protein. While this amyloid protein was determined to be aggregated at pH 7 and pH 2, in particular, this protein at pH 3 appears to be in a monomeric state in the burst phase analysis performed. In addition, the protein at pH 3 appears to suffer a hydrophobic collapse with the formation of a possible folded intermediate. This folded intermediate seems to result from a fast contraction of the disordered amyloid polypeptide chain, which is proceeded by an expansion of the protein, due to the occurrence of solvent-dependent modification effects in a milliseconds time scale of the burst phase. Generally, it can be argued that both literature criteria of solvent-dependent modifications of the disordered Syn amyloid protein and of the formation of its possible folded intermediate are very likely to occur in the burst phase.
Binge Drinking and Depression Symptoms as Risk Factors for Teen Dating Violence Among Sexual Minority Youth
Authors: Thaxton Taylor , Nguyen Angela-Maithy , Prata Ndola 
Published: June 2023

Abstract

Purpose
Given sexual minority youth (SMY) are disproportionately impacted by teen dating violence (TDV), this study assessed binge drinking and depression symptoms as possible risk factors contributing to this disparity.

Methods
Cross-sectional survey data collected from a nationally representative sample of SMY high school students in the United States in 2017 and 2019 through the national Youth Risk Behavior Surveillance System (YRBSS) (n = 3,424) was used to create 3 logistic regression models. The models estimated the associations between the exposures, binge drinking and depression symptoms, and TDV, including physical TDV, sexual TDV, or both. Additionally, we hypothesized that these associations would be stronger in SMY than heterosexual youth. Therefore, we expanded the study population to include SMY and heterosexual youth (n = 22,798) and tested for interaction.

Results
Both binge drinking (adjusted odds ratio [aOR]: 2.6, 95% confidence interval [CI]: 1.8–3.8) and symptoms of depression (aOR: 2.7, 95% CI: 1.8–4.02) were positively associated with TDV among SMY. Additionally, binge drinking was associated with a significantly greater risk of victimization for SMY (aOR = 2.7, 95% CI 1.9–3.9) than heterosexual youth (aOR = 1.5, 95% CI 1.2–2.0).

Conclusions
Our results suggest that while both exposures are associated with an increased risk of both physical and sexual TDV, binge drinking may contribute to the disparate rates of dating violence impacting SMY.
Radiolabeling and evaluation of fonturacetam hydrazide as a radiotracer for visualization of brain function
Authors: El-Kawy O. A. , Shweeta H. A. , Sallam Kh. M. 
Published: June 2023

Abstract[99mTc] fonturacetam hydrazide was radiosynthesized to assess neuropsychiatric disorders by targeting the brain. The nootropic drug was labeled with technetium-99m, and factors affecting the labeling yield were studied. At optimum conditions, the radiocomplex was obtained at a high radiochemical yield (98.9%) and was stable in saline for up to 36 h and serum for more than 24 h. Labeled fonturacetam hydrazide was characterized and assessed in silico. Biodistribution studies in mice showed that the brain uptake of the complex was 8.8% injected dose per gram (% ID/g) at 5 min post-injection, surpassing the commercially available [99mTc] ECD (4.7% ID/g) and [99mTc] HMPAO (2.25% ID/g). All results suggested that the tracer is a good candidate to image the human brain for assessing neuropsychiatric disorders.
Black Women’s Perceptions Towards Infant and Child Male Circumcision
Authors: Palmer Eurica , Marais Lochner , Engelbrecht Michelle 
Published: June 2023

Abstract
Objective
The objective of this article was to analyse women’s perceptions of ICMC and to propose a framework for ICMC decision-making that can inform ICMC policies.

Method
Using qualitative interviews, this study investigated twenty-five Black women’s perceptions of ICMC decisionmaking in South Africa. Black women who had opted not to circumcise their sons, were selected through purposive and snowball sampling. Underpinned by the Social Norms Theory, their responses were analysed through in-depth interviews and a framework analysis. We conducted the study in the townships of Diepsloot and Diepkloof, Gauteng, South Africa.

Results
Three major themes emerged: medical mistrust, inaccurate knowledge leading to myths and misconceptions, and cultural practices related to traditional male circumcision. Building Black women’s trust in the public health system is important for ICMC decision-making.

Conclusions for Practice
Policies should address misinformation through platforms that Black women share. There should be an acknowledgement of the role that cultural differences play in the decision-making process. This study developed an ICMC perception framework to inform policy.
Black-box assisted medical decisions: AI power vs. ethical physician care
Authors: Chan Berman 
Published: June 2023

AbstractI raise an ethical problem with physicians using “black box” medical AI algorithms, arguing that its use would compromise proper patient care. Even if AI results are reliable, my contention is that without being able to explain medical decisions to patients, physicians’ use of black box AIs would erode the effective and respectful care they provide patients. In addition, I argue that physicians should use AI black boxes only for patients in dire straits, or when physicians use AI as a “co-pilot” (analogous to a spellchecker) but can independently confirm its accuracy. My argument will be further sharpened when, lastly, I give important attention to Alex John London’s objection that physicians already sometimes prescribe treatment, such as lithium drugs, even though neither researchers nor doctors can explain why the treatment works.
Future dynamic multimedia content access via aerial computing system
Authors: Periola Ayodele , Alonge Akintunde , Ogudo Kingsley 
Published: June 2023

AbstractMultimedia content access sovereignty arises due to the intention of producers to enable subscribers from pre–defined regions access multimedia content. This limits the number of locations (with subscribers) that can access producer content. Therefore, the ability to access multimedia content across previously unconsidered locations is limited. The presented research addresses this challenge and focuses on multimedia content sharing among subscribers in arid and hyper–arid regions. The use of stratosphere based data centres (SBDCs) is proposed. The paper also presents multi–tier network architecture for network traffic management. This ensures that network traffic congestion does not limit access to multimedia content by subscribers across multiple regions. The use of SBDCs increases the number of locations that engage in the sharing of multimedia content. Evaluation shows that the proposed solution increases the number of data sharing locations by (75.8 – 88.2) % on average.
Analysis of layered information dissemination model and caching strategy in Social Internet of Things
Authors: Zhang Yuexia , Pan Dawei , Fan Shaoshuai 
Published: June 2023

AbstractIn recent years, the social Internet of Things (SIoT) and its applications have developed rapidly and introduced convenience to people’s lives. In view of the massive amount of information generated by the SIoT, it is necessary to model and analyze the communication among smart devices and study the impact of social attributes of smart devices on information dissemination. Therefore, in this study, we propose a layered information dissemination model for SIoT that abstracts the communication process in SIoT as the information dissemination process among nodes, describes the process of wireless communication in SIoT using the microscopic Markov chain method, and derives the information dissemination threshold based on theoretical analyses. In addition, this study proposes a dynamic cache strategy considering the influence of social attributes, such as user interestingness, information popularity, and the interaction between messages on communication. Finally, the correctness of the model and propagation threshold and the effectiveness of the caching strategy are verified by simulation experiments in artificial networks and real networks.
Rhizobial benefits to an herbaceous invader depend on context and symbiotic strain
Authors: Ramula Satu , Mousavi Seyed Abdollah , Kalske Aino 
Published: June 2023

Abstract
Background and aims
For invasive plant species that associate with mutualistic symbionts, partner quality can be critical to their invasion success. This might be particularly true for legumes that host nitrogen-fixing bacteria (rhizobia). Here, we examined the relative effectiveness of rhizobial strains on the invasive legume Lupinus polyphyllus.

Methods
We isolated rhizobia from field populations of L. polyphyllus and conducted inoculation experiments in which we quantified plant growth in greenhouse and common-garden conditions.

Results
Differences in nodulation and effectiveness in terms of increasing plant growth among rhizobial strains of the genus Bradyrhizobium were more pronounced in the greenhouse than in the common garden. All six rhizobial strains nodulated the host plant in greenhouse conditions, but one failed to nodulate in the common garden. Under greenhouse conditions, five rhizobial strains increased plant biomass by 66–110%, while one provided negligible benefits compared to control plants without rhizobia, suggesting that rhizobial identity might be critical to the invader’s performance. However, the common-garden experiment revealed no differences in the effectiveness of rhizobial strains in terms of plant biomass, number of leaflets per leaf, height, root:shoot ratio, or survival. Moreover, the performance of rhizobia-inoculated plants in the common garden did not differ from plants without rhizobia, which may call into question the fitness benefits of rhizobia to field populations of this species.

Conclusions
The discrepancies observed between the two environments highlight the importance of considering field-realistic growing conditions and multiple plant traits when assessing the potential growth benefits of symbiotic partners to host plants.
Positive weights in data envelopment analysis
Authors: Hasannasab Maryam , Margaritis Dimitris , Roshdi Israfil , Rouse Paul 
Published: June 2023

AbstractData Envelopment Analysis (DEA) models give each decision making unit freedom to assign values to the input-output weights maximising its efficiency score. However, there is no guarantee that the optimal weights obtained from a DEA model are always positive which poses a problem, in both theory and practice. This paper offers new linear programming models to deal with the zero weights problem without restricting the weights or placing prior value judgments on them while maintaining the original DEA frontier. These models generate a profile of weights with the maximum number of positive weights applicable to both envelopment and multiplier DEA settings. These linear programs still allow weight flexibility and are independent of the solver. We show how these models can be modified to provide unit-specific positive weights. We illustrate the relevance of our approach using artificial and real world data.
A novel text representation which enables image classifiers to also simultaneously classify text, applied to name disambiguation
Authors: Petrie Stephen M. , Julius T’Mir D. 
Published: June 2023

AbstractWe introduce a novel method for converting text data into abstract image representations, which allows image-based processing techniques (e.g. image classification networks) to be applied to text-based comparison problems. We apply the technique to entity disambiguation of inventor names in US patents, obtaining a list of IDs which identify individual inventors with high accuracy. The method involves converting text from each pairwise comparison between two inventor name records into a 2D RGB (stacked) image representation. We then train an image classification neural network to discriminate between such pairwise comparison images. The trained neural network then labels each pair of records as either matched (same inventor) or non-matched (different inventors), producing highly accurate results. Our new text-to-image representation method could also be used more broadly for other text comparison problems, such as entity disambiguation of academic publications, or for problems that require simultaneous classification of both text and image datasets.
Distinctive substantial self-knowledge and the possibility of self-improvement
Authors: Corbí Josep E. 
Published: June 2023

AbstractQuassim Cassam distinguishes between trivial and substantial cases of self-knowledge. At first sight, trivial cases are epistemically distinctive insofar as the agent needn't provide any sort of evidence to ground her claim to knowledge. Substantial cases of self-knowledge such as ‘I know I want to have a second child’ do not seem to bear this distinctive relation to evidence. I will argue, however, that substantial cases of self-knowledge are often epistemically distinctive and, to this end, I will challenge a crucial assumption in the current debate about self-knowledge, namely: if a piece of self-knowledge is based on evidence, it must have been delivered by a detached, theoretical attitude toward oneself (The Detachment Assumption).My case against the Detachment Assumption combines a negative and a positive programme. Regarding the negative aspect, I will first present Cassam's case for Inferentialism; second, I will argue that this view about self-knowledge is at odds with the sort of self-improvement that he vindicates in his analysis of epistemic vices and, third, I will conclude that only by allowing for an engaged relation to evidence, can we make sense of that sort of self-improvement. Regarding the positive programme, I will first examine the sensitivity to the music that is specific of a graceful dancer and, on this basis, outline an attitude toward oneself that, despite involving evidence, is not detached or theoretical but engaged, so that it gives rise to a kind of substantial self-knowledge that is both transformative and epistemically distinctive.
Water Harvesting by Molecular Sieves Using Self-sustained Continuous Flow
Authors: Torres-Herrera Ulises , Ballesteros-Rivas María Fernanda , Varela-Guerrero Víctor , Balmaseda Jorge 
Published: June 2023

AbstractA way of harvesting water from the air that avoids the discontinuity of the adsorption/desorption cycles is theoretically analyzed. A rectangular prism-shaped adsorbent bed is immersed in low-humidity air, at an angle to the horizontal and subject to a temperature gradient between two opposite and open faces. The other four faces of the prism remain isolated. Water is adsorbed on the adsorbent colder face, causing a density gradient in the surrounding air, parallel to the surface, that results in a self-sustained continuous air flow. On the opposite face, a self-sustained continuous air flow parallel to the surface also arises, but this time due to a temperature gradient in the air surrounding the hot bed face. In addition, its higher temperature causes the desorption of water from the adsorbent. This overall water exchange produces the enrichment of water content in one of the air streams that is crucial to produce water harvesting. The performance of Al-Fumarate, MOF-303, SAPO-34 and Zeolite 13X is tested, unveiling the key factors that increase flow rate and water concentration at the enriched phase. It has been found that the diffusive mass transport at the air-solid interphase is the bottleneck of water harvesting in continuous flow conditions. Therefore, if high concentration of water is desired, it is necessary to use porous materials with very high diffusitivities. These findings provide the foundations for the design of continuous water harvesting devices.
Endocrine immune-related adverse events in patients with metastatic renal and urothelial cancer treated with immune checkpoint-inhibitors
Authors: Oppolzer Immanuel Augustin , Riester Josef , Büttner Roland , Burger Maximilian , Schnabel Marco Julius 
Published: June 2023

Abstract
Purpose
To evaluate the incidence, diagnosis and treatment of immune-related adverse events (e-irAE) of checkpoint inhibition (ICI) in metastatic urothelial carcinoma (mUC) and metastatic renal cell carcinoma (mRCC).

Methods
A retrospective, single-center study was conducted to identify a cohort that received ICI for mUC or mRCC. e-irAE were classified according to the CTCAE V.5.0. Patients received ICI for mUC or mCC between 01/2017 and 03/2021. A retrospective chart review was performed. T-Test, the chi-squared test, and Fisher's exact test were performed.

Results
102 Patients received ICI [mUC: 40 (39%), mRCC: 62 (61%)]. 64 (63%) received an ICI monotherapy, 27 (27%) a dual ICI therapy, 11 (11%) a combination with VEGFi. e-irAE occurred in 19 (19%) patients [grade 1–2: 17 (84%), grade 3: 3 (16%)]. The median time until e-irAE was 42 days (range 11–211 days). 14 Patients developed thyroidism (14%), 4 (4%) a hypophysitis, 1 (1%) an adrenal insufficiency (AI). 7 patients (7%) had to discontinue ICI therapy [hypophysitis (100%), AI (100%), thyroidism (14%)]. 6 (86%) received cortisone. After a median range of 34 days 5 patients (71%) restarted ICI therapy. All patients (n = 4) with hypophysitis continued ICI [4 (100%) prednisone, 3 (75%) levothyroxine]. 11 (79%) presented with hyperthyroidism. 4 (37%) needed therapy (1 (7%) prednisone, 3 (21%) thiamazole, 2 (14%) beta blocker). The 9 (64%) patients with hypothyroidism received levothyroxine. Hypophysitis appears only on dual ICI (CTLA-4/PD-1) inhibition (p 0.007).

Conclusion
This study shows the importance of adequate diagnosis and therapy of e-irAEs.