bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensus on acute behavioural disturbance in the UK: a multidisciplinary modified Delphi study to determine what it is and how it should be managed
Authors: Humphries Christopher , Kelly Anthony , Sadik Aws , Walker Alison , Smith Jason 
Published: September 2023

BackgroundAcute behavioural disturbance (ABD) is a term used in law enforcement and healthcare, but there is a lack of clarity regarding its meaning. Common language should be used across staff groups to support the identification, prioritisation and delivery of care to this group of patients. The terminology currently used is inconsistent and confusing. This study aimed to reach a consensus on the criteria for identification and management of ABD, and to agree when other care pathways or guidelines might be more appropriately used.MethodsA modified Delphi study with participation from stakeholder organisation representatives was conducted in January–April 2023 online. In round 1, statements were generated by participants in response to broad questions. Participants then rated their level of agreement with statements in subsequent rounds, with statements achieving a consensus removed for inclusion in the final derived consensus statement. Non-consensus statement responses were assessed for stability.ResultsOf 430 unique statements presented for rating, 266 achieved a consensus among 30 participants representing eight stakeholder organisations. A derived consensus statement was generated from these statements. The median group response to statements which failed to achieve a consensus was reliable (Krippendorff’s alpha=0·67).ConclusionsThere is a consensus across stakeholder organisations that ABD is not a separate entity to agitation, and guidance should instead be altered to address the full range of presentations of agitation. While the features of concern in this severely agitated group of patients can be described, the advice for recognition may vary depending on staff group. Criteria for recognition are provided and potential new terminology is described.
A simulated search for the singlet vector-like bottom quark decaying into tW at high energy pp colliders
Authors: Han Jinzhong , Shang Liangliang , Yang Bingfang 
Published: September 2023

AbstractIn a framework of simplified model, we perform a simulated search for the singlet vector-like bottom quark B decaying into tW with t hadronic decay and W leptonic decay at the 14 TeV high-luminosity LHC (HL-LHC), 27 TeV high energy LHC (HE-LHC) and 100 TeV Future Circular Hadron Collider (FCC-hh). In this work, we focus on the case that the B only couples with the third generation quarks of the Standard Model. We make a detailed detector simulations of the signal and backgrounds and obtain the $$2\sigma $$

2
σ

exclusion limit and $$5\sigma $$

5
σ

discovery prospects. Our results show that the upcoming HL-LHC can exclude (discover) the $$m_B$$

m
B

to 2100 (1900) GeV for a typical coupling strength $$g^{*}=0.2$$

g

∗

=
0.2

. For the HE-LHC (FCC-hh), this exclusion capability on the B quark mass can be expanded to more than 3000 (5000) GeV.
Risk and prognostic factors in patients with colon cancer with liver metastasis
Authors: Gao Jiawei , Zhuang Linjun , He Chenxin , Xu Xiangrong , Zhu Zhaobi , Chen Wei 
Published: September 2023

Objective The most common site of metastasis in patients with colon cancer is the liver. This study aimed to identify patients with colon cancer at high risk of developing liver metastasis and to explore their prognosis. Methods The clinical characteristics, treatment methods and survival outcomes of patients diagnosed with colon cancer from 2010 to 2015 were identified from the Surveillance, Epidemiology and End Results (SEER) database. Patients were divided into two groups according to the presence of liver metastasis, and multivariate logistic and Cox regression models were used to identify risk and prognostic factors. Results A total of 60,018 patients with colon cancer were selected from the SEER database. The incidence of liver metastasis was 9.2%. African American ethnicity, poor differentiation, higher tumor stage, higher lymph node ratio, and lung metastases were common factors associated with both liver metastasis risk and prognosis. Conclusions Metastasectomy might improve survival among patients with colon cancer with resectable liver metastasis lesions and no other organ involvement.
Caregiving occupations, health and well-being of Chinese mothers of children with disabilities living in Australia, Singapore and Taiwan
Authors: Sim So Sin , Bourke-Taylor Helen , Yu Mong-Lin , Fossey Ellie , Tirlea Loredana 
Published: September 2023

Introduction: Mothers of children with disabilities report increased maternal stress, compromised mental health and reduced leisure and social participation compared with other mothers. The aim of the study was to explore the similarities and differences between three groups of Chinese mothers of children with disabilities in their caregiving occupations and selected maternal variables. Methods: An online survey collected mothers’ demography, caregiving occupations and six maternal measures: frequency in participation in health promoting activities, mental well-being, personal well-being, psychological distress, perceived support and perceived stigma. Descriptive and inferential statistics were used to investigate group similarities and differences, and detect associations between variables. Results: The survey responses of Chinese mothers ( N = 261) from Australia ( n = 80), Singapore ( n = 95) and Taiwan ( n = 86) were analysed. Similarities and differences in caregiving occupations were found between groups. The Kruskal–Wallis test showed no differences in maternal variables between groups. There were associations found between some caregiving occupations and maternal variables when mothers were analysed as a single group. Conclusion: The health and well-being of mothers of children with disabilities may be influenced more by their cultural similarities than differences in their socio-political environments. Recognising cultural influences on caregiving occupations is crucial in the delivery of culturally competent and culturally intelligent practice.
The Effect of Lullabies and Classical Music on Preterm Neonates’ Cerebral Oxygenation, Vital Signs, and Comfort During Orogastric Tube Feeding: A Randomized Controlled Trial
Authors: Bağli Esra , Küçükoğlu Sibel , Soylu Hanifi 
Published: September 2023

Objective This study investigated the effect of lullabies and classical music on preterm neonates’ cerebral oxygenation, vital signs, and comfort during orogastric (OG) tube feeding. Methods This was a parallel-group pretest-posttest randomized controlled study. The research was conducted between December 2020 and May 2022. The sample consisted of 51 preterm neonates hospitalized in the neonatal intensive care unit (NICU) of Selçuk University Faculty of Medicine Hospital in Konya, Türkiye. Participants were randomized into three groups (17 preterm infants in each group). The first group listened to lullabies sung by their mothers and the second group listened to classical music during OG tube feeding. The control group received routine care with no music. Data were collected using a Neonatal Identification Information Form, Physiological Parameters and rSO2 Monitoring Form, and the Newborn Comfort Behavior Scale (Comfort-Neo). The study was registered on the ClinicalTrials database (NCT05333575). Results The lullaby group had stable peak heart rates and oxygen saturation levels ( p = .002). Both lullaby and classical music groups had significantly higher cerebral oxygenation levels than the control group. The classical music group had the highest cerebral oxygenation level ( p = .001). Both lullaby and classical music groups had significantly higher mean Comfort-Neo scores than the control group. The classical music group had the highest mean Comfort-Neo score ( p = .040). Conclusion Preterm neonates who listen to lullabies and classical music are likely to have higher cerebral oxygen and comfort levels. Listening to lullabies helps stabilize vital signs. These results suggest that healthcare professionals should encourage parents to get their preterm neonates to listen to lullabies and classical music.
SARS-CoV-2 Burden in Wastewater and its Elimination Using Disinfection
Authors: Koirala Prashanna , Dhakal Sandesh , Malla Bikram , Ghimire Archana , Siddiqui Mohammad Ataullah , Dawadi Prabin 
Published: September 2023

Background: Pathogenic viruses have been abundant and diverse in wastewater, reflecting the pattern of infection in humans. Human feces, urine, and perhaps other washouts that frequently circulate in sewage systems may contaminate wastewater with SARS-CoV-2. It’s crucial to effectively disinfect wastewater since poorly handled wastewater could put the population at risk of infection. Aims: To emphasize the presence and spread of SARS-CoV-2 in sewage (wastewater) through viral shedding from the patients to detect the virus in the population using wastewater-based epidemiology. Also, to effectively manage the transmission of SARS-CoV-2 and reduce the spread of the virus in the population using disinfectants is highlighted. Methods: We evaluated articles from December 2019 to August 2022 that addressed SARS-CoV-2 shedding in wastewater and surveillance through wastewater-based epidemiology. We included the papers on wastewater disinfection for the elimination of SARS-CoV-2. Google Scholar, PubMed, and Research4Life are the three electronic databases from which all of the papers were retrieved. Results: It is possible for viral shedding to get into the wastewater. The enumeration of viral RNA from it can be used to monitor virus circulation in the human community. SARS-CoV-2 can be removed from wastewater by using modern disinfection techniques such as sodium hypochlorite, liquid chlorine, chlorine dioxide, peracetic acid, and ultraviolet light. Conclusion: SARS-CoV-2 burden estimates at the population level can be obtained via longitudinal examination of wastewater, and SARS-CoV-2 can be removed from the wastewater through disinfection.
Assessment and treatment of mental health conditions in children and adolescents: A systematic scoping review of how virtual reality environments have been used
Authors: Blanco Dana , Roberts Rachel M , Gannoni Anne , Cook Steve 
Published: September 2023

Background There is growing interest in the use of virtual reality environments (VREs) in psychological treatment and assessment. Most research has focused on the application of VREs in adult psychological disorders with fewer studies focusing on its applicability with children and adolescents. A systematic scoping review was undertaken of research assessing how VREs have been used in the treatment and assessment of childhood mental health disorders to provide an overview of the current state of the literature and identify future research directions. Method Systematic searches of online databases were conducted in PsycInfo, PubMed, Embase, Scopus, and Web of Science. Results Eleven studies met eligibility criteria and were included in this review, with the majority focusing on VRE interventions for anxiety-related disorders. There is also emerging support for VRE deep breathing training for anxiety, VRE assisted treatment of internet gaming disorder and anorexia nervosa, and VRE assessment of body image evaluation in anorexia nervosa. Most studies were pilot and feasibility studies with only three randomised-controlled trials (RCT). Conclusions The current literature shows some promise for the use of VRE assessments and interventions of childhood mental health problems, particularly for anxiety-related disorders such as social anxiety and specific phobias. However, high-quality RCTs are now needed to establish effectiveness of VREs in this population, and how it compares to existing evidence-based approaches, given its promise to improve both engagement and outcomes.
Snapshots of Family: Family Representations and Practices of Mothering Displayed by Instamothers
Authors: Gawrońska Małgorzata , Sikorska Małgorzata 
Published: September 2023

The article explores family representations and practices of mothering displayed by popular Polish Instamothers. We investigate how ‘proper’ motherhood is constructed also with regard to strategies of depicting children and making social class manifest. Janet Finch’s concept of ‘displaying families’ is applied as both a theoretical framework and a set of methodological assumptions. Considering sharing family images on Instagram as a form of display, we assume that published photographs both shape and are shaped by dominant norms and discourses. Relying on content analysis and on semiological analysis, we investigate 100 photographs published by 10 popular Instamothers. The ethical challenges in visual social media research are also discussed. As a solution to the data anonymization problem, we propose the usage of graphics based on photographs. The results identify a tendency to idealize family life and to promote the traditional family model with its strongly normative character. Simultaneously, elements of the family modernizing discourse are also present. Although limited to Poland, our case study has broader significance for examining the dynamic socio-cultural changes that occur in postmodern societies.
Back in Action: High Return to Pre-Injury Level of Sports after Arthroscopic Bone Marrow Stimulation for Osteochondral Lesions of the First Metatarsophalangeal (MTP-1) Joint
Authors: ter Laak Bolk Carlijn S. , Rikken Quinten G.H. , Dahmen Jari , Shimozono Yoshiharu , Takao Masato , Stufkens Sjoerd A.S. , Kerkhoffs Gino M.M.J. 
Published: September 2023

Objective The primary aim was to assess the return to sports outcomes of patients with symptomatic osteochondral lesions (OCLs) to the first metatarsophalangeal (MTP-1) joint treated by arthroscopic bone marrow stimulation (BMS). Secondary aims were to present patient-reported outcome measures (PROMs) on pain scores as well as surgery-related complications or reoperations to the MTP-1 joint. Design All patients with MTP-1 OCLs treated by arthroscopic BMS with a minimum follow-up of 12 months were included. Outcomes included return to sports and work outcomes, satisfaction outcomes with the performed treatment, PROMs, as well as postoperative complications and reoperations. Medical records were screened by 2 independent reviewers and patients were contacted by phone to partake in an in-depth interview. Complications, reoperations, and revision surgeries were additionally assessed. Results Nine patients (median age: 22 years with interquartile range (IQR) 20-29 years) were included with a median follow-up time of 47 (IQR: 23-92) months. Six (86%) out of 7 patients who participated in sports preoperatively returned to sports at any level at a median of 4 (IQR: 2.6-5.8) months. Five patients (71%) returned to pre-injury level of sport and eventually returned to performance at a median of 4 (IQR 2.8-7.5) and 8 (IQR: 4.0-10.5) months, respectively. The median Numeric Rating Scale for pain during walking was 1 (IQR 0-2.5) and all (100%) patients were able to return to work at a median of 4 (IQR: 2-17) weeks. Eighty-nine percent of the patients were very or fairly satisfied with the result of their treatment. No complications, reoperations, or revision surgeries were reported. Conclusions Arthroscopic BMS for patients with symptomatic OCLs to the MTP-1 joint can be considered safe and yields an 86% return to sport at any level and a 71% return to pre-injury and performance level, with good clinical, return to work, as well as satisfaction outcomes.
Vitamin D Deficiency and Its Association With Anemia and Blood Transfusion Requirements in Nigerian Adults With Sickle Cell Anemia
Authors: Ochogwu Olanrewaju Lauretta , Salawu Lateef , Owojuyigbe Temilola Oladunmomi , Adedeji Tewogbade Adeoye 
Published: September 2023

Background Vitamin D supplementation has been shown to improve hemoglobin levels in patients with sickle cell anemia (SCA). However, very little is known about the prevalence of its deficiency, its role in hemolysis, and its effects on transfusion requirements in SCA, hence this study. Patients and Methods Serum level of vitamin D was determined in 50 SCA patients in steady state, 50 SCA patients in hemolytic crises, and 50 in normal HbAA individuals. All were 18 years or older and were age- and sex-matched. In addition, PCV and hemoglobin (Hb) concentration, absolute reticulocyte count, uric acid, total and conjugated bilirubin, creatinine, lactate dehydrogenase (LDH), and estimated glomerular filtration rate (eGFR) were also assessed in all subjects and controls. Baseline sociodemographic, clinical, and anthropometric data were also recorded. Results The prevalence of vitamin D insufficiency and deficiency was found to be 18% and 79%, respectively. The mean serum levels of vitamin D were 18.84 ± 6.86 ng/mL and 17.58 ± 6.23 ng/mL in the steady-state and the hemolytic crises SCA groups, respectively. Transfusion requirements were found to be higher in SCA patients with lower vitamin D levels. Unlike those in crisis who received one or more units of blood transfusion, 42% of those in the steady state did not receive blood transfusion over the same period of 12 months. Hemoglobin levels were, however, found to predict reduced vitamin D levels. Conclusion Vitamin D deficiency (VDD) is highly prevalent among adults with SCA and those with lower vitamin D levels are more anemic and hence may require more blood transfusions.
Derivation of a Pharmacokinetic Model to Include a Plasma-Derived, von Willebrand Factor-Containing Factor VIII (Koate®-DVI) Concentrate and its Low-Dose Use
Authors: Hajducek Dagmar M. , Primacakti Fitri , Chozie Novie , Mir Roser , McEneny-King Alanna , Iorio Alfonso , Edginton Andrea 
Published: September 2023

Background Population pharmacokinetics (popPK) has been reliably leveraged to generate individual PK in hemophilia patients. Specific popPK models are suited to predict individual PK under a variety of scenarios that may not be captured by clinical trials, allowing for individualized prophylactic treatment. The Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) project generates individually predicted pharmacokinetic profiles relying on concentrate-specific popPK models used for Bayesian forecasting. Objective Specification of a popPK model for the plasma-derived factor VIII (FVIII) concentrate Koate-DVI and its suitability for pharmacokinetic estimation in low-dose scenarios. Methods A popPK model was developed for Koate-DVI WAPPS-Hemo PK data in combination with the existing WAPPS-Hemo Fanhdi/Alphanate model derivation dataset using nonlinear mixed effects modelling, and was validated via cross-validation and prediction-corrected Visual Predictive Checks (pcVPC). Bootstrap and PK outcomes between the Fanhdi/Alphanate and the Fanhdi/Alphanate/Koate models were compared, and the relative error distributions from a limited sampling analysis (LSA) under the latter model for low and normal doses (10 vs 50 IU/kg) and inclusion/exclusion of pre-dose measurements. Results A Fanhdi/Alphanate/Koate model was derived (126 patients, ages 1–71 years) after deeming a Koate-brand covariate not clinically significant, resulting in similar parameter estimates than the Fanhdi/Alphanate model with satisfactory goodness of fit, cross-validation and pcVPC results. Low-dose predictions resulted in a higher accuracy and slightly lower precision of half-life ([Formula: see text]-phase) and time to 2% trough (TAT2%) estimates than normal dose (median absolute bias for half-life: 0.12 vs 0.5%; median interquartile range, IQR: 11.79% vs 9.95%). Precision improved under pre-dose designs by 2 to 3% and remained similar between 5- and 2-sample designs (IQR reduction<1.8%). Conclusions The Fanhdi/Alphanate/Koate model is appropriate for Bayesian forecasting in the WAPPS-Hemo platform, providing a comparable prediction capability for low and normal dosing regimens (10 vs 50 IU/Kg).
Reinforced antimyeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with bridging-BiTE
Authors: Konishi Tatsuya , Ochi Toshiki , Maruta Masaki , Tanimoto Kazushi , Miyazaki Yukihiro , Iwamoto Chika , Saitou Takashi , Imamura Takeshi , Yasukawa Masaki , Takenaka Katsuto 
Published: September 2023

Abstract
Immunotherapy using bispecific antibodies including bispecific T-cell engager (BiTE) has the potential to enhance the efficacy of treatment for relapsed/refractory multiple myeloma. However, myeloma may still recur after treatment because of downregulation of a target antigen and/or myeloma cell heterogeneity. To strengthen immunotherapy for myeloma while overcoming its characteristics, we have newly developed a BiTE-based modality, referred to as bridging-BiTE (B-BiTE). B-BiTE was able to bind to both a human immunoglobulin G–Fc domain and the CD3 molecule. Clinically available monoclonal antibodies (mAbs) were bound with B-BiTE before administration, and the mAb/B-BiTE complex induced antitumor T-cell responses successfully while preserving and supporting natural killer cell reactivity, resulting in enhanced antimyeloma effects via dual-lymphoid activation. In contrast, any unwanted off-target immune-cell reactivity mediated by mAb/B-BiTE complexes or B-BiTE itself appeared not to be observed in vitro and in vivo. Importantly, sequential immunotherapy using 2 different mAb/B-BiTE complexes appeared to circumvent myeloma cell antigen escape, and further augmented immune responses to myeloma relative to those induced by mAb/B-BiTE monotherapy or sequential therapy with 2 mAbs in the absence of B-BiTE. Therefore, this modality facilitates easy and prompt generation of a broad panel of bispecific antibodies that can induce deep and durable antitumor responses in the presence of clinically available mAbs, supporting further advancement of reinforced immunotherapy for multiple myeloma and other refractory hematologic malignancies.
HEXIM1 is an essential transcription regulator during human erythropoiesis
Authors: Lv Xiurui , Murphy Kristin , Murphy Zachary , Getman Michael , Rahman Nabil , Nakamura Yukio , Blanc Lionel , Gallagher Patrick G. , Palis James , Mohandas Narla , Steiner Laurie A. 
Published: September 2023

Abstract
Regulation of RNA polymerase II (RNAPII) activity is an essential process that governs gene expression; however, its contribution to the fundamental process of erythropoiesis remains unclear. hexamethylene bis-acetamide inducible 1 (HEXIM1) regulates RNAPII activity by controlling the location and activity of positive transcription factor β. We identified a key role for HEXIM1 in controlling erythroid gene expression and function, with overexpression of HEXIM1 promoting erythroid proliferation and fetal globin expression. HEXIM1 regulated erythroid proliferation by enforcing RNAPII pausing at cell cycle check point genes and increasing RNAPII occupancy at genes that promote cycle progression. Genome-wide profiling of HEXIM1 revealed that it was increased at both repressed and activated genes. Surprisingly, there were also genome-wide changes in the distribution of GATA-binding factor 1 (GATA1) and RNAPII. The most dramatic changes occurred at the β-globin loci, where there was loss of RNAPII and GATA1 at β-globin and gain of these factors at γ-globin. This resulted in increased expression of fetal globin, and BGLT3, a long noncoding RNA in the β-globin locus that regulates fetal globin expression. GATA1 was a key determinant of the ability of HEXIM1 to repress or activate gene expression. Genes that gained both HEXIM1 and GATA1 had increased RNAPII and increased gene expression, whereas genes that gained HEXIM1 but lost GATA1 had an increase in RNAPII pausing and decreased expression. Together, our findings reveal a central role for universal transcription machinery in regulating key aspects of erythropoiesis, including cell cycle progression and fetal gene expression, which could be exploited for therapeutic benefit.