bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced therapeutic effects of mesenchymal stem cell-derived extracellular vesicles within chitosan hydrogel in the treatment of diabetic foot ulcers
Authors: Yang Shuangshuang , Chen Siyu , Zhang Chengpeng , Han Jing , Lin Chunyuan , Zhao Xiaohui , Guo Huizhen , Tan Yi 
Published: August 2023

AbstractExtracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising candidates for cell-free therapy in various diseases, including chronic cutaneous wounds. However, the lack of standardized protocols for EVs’ preparation and identification poses a significant challenge to their clinical application. Thus, the objective was to develop a safe and efficient method for the large-scale production of hUCMSC-derived EVs while establishing a comprehensive identification protocol encompassing morphology, particle size distribution, protein expression, and purity. This study observed that most of the EVs acquired through the protocol exhibited either a cup-shaped or round-shaped structure, with a median diameter of ~73.25 nm. The proportions of EVs positive for CD9, CD63, and CD81 were 37.5%, 38.6%, and 19.8%, respectively. To enhance their therapeutic potential in wound treatment, EVs were incorporated into chitosan hydrogel, forming chitosan hydrogel-EVs (CS-EVs). Furthermore, it was demonstrated that CS-EVs exhibited continuous release of EVs into the surrounding environment and, importantly, that the released EVs were internalized by human umbilical vein endothelial cells (HUVECs), resulting in significant enhancement of cell migration and angiogenesis. Additionally, in a rat model of diabetic foot ulcers, CS-EVs demonstrated a robust therapeutic effect in promoting wound healing. Following a 15-day treatment period, the group treated with CS-EVs demonstrated an impressive 93.3% wound closure ability, accompanied by a high degree of re-epithelialization. In contrast, the control group exhibited only a 71.5% reduction in wound size. In summary, this study offers solutions for the purification, characterization, and application of EVs in clinical wound treatment. These results not only offer fresh perspectives on the involvement of hUCMSC-derived EVs in wound healing but also introduce a non-invasive approach for applying EVs that holds practical significance in skin repair.
Graphical Abstract
Inequality and Social Distancing during the Pandemic
Authors: Brown Caitlin , Ravallion Martin 
Published: August 2023

AbstractWe study how pre-pandemic inequalities in the United States influenced social distancing over the course of the COVID-19 pandemic. Richer counties tended to see more protective mobility responses in the initial (pre-pharmaceutical) phase, but less protective responses later. Near linearity of this income effect implies that inequality between counties contributed very little to overall mobility reductions. By contrast, higher within-county inequality and/or poverty came with substantially larger attenuations to non-residential mobility at given average incomes. There were also significant effects of the county’s racial and age composition. County employment composition is found to be additionally important, with reductions in mobility in counties with a higher share of professional workers.
Throughflow effect on bi-disperse convection
Authors: Capone Florinda , De Luca Roberta , Massa Giuliana 
Published: August 2023

AbstractThe aim of this paper is to investigate the effect of a vertical constant throughflow on convective instabilities in a horizontal layer of fluid-saturated bi-disperse porous medium heated from below. Via linear instability and nonlinear stability analyses of the throughflow solution, the linear and nonlinear critical Rayleigh numbers for convective instabilities have been determined and studied as functions of the strength of the throughflow.
Impact of lymphovascular invasion on otherwise low-risk papillary thyroid carcinomas: a retrospective and observational study
Authors: Puga Francisca Marques , Al Ghuzlan Abir , Hartl Dana M. , Bani Mohamed-Amine , Moog Sophie , Pani Fabiana , Breuskin Ingrid , Guerlain Joanne , Faron Matthieu , Denadreis Desirée , Baudin Eric , Hadoux Julien , Lamartina Livia 
Published: August 2023

Abstract
Purpose
Presence of venous vascular invasion is a criterion of intermediate risk of recurrence in papillary thyroid carcinoma (PTC). However, the presence and type of vascular invasion (lymphatic or venous) is often underreported and its impact on PTCs without other risk features remains unknown. The aim of this study was to evaluate the impact of both lymphatic and venous invasion on the risk of recurrence/persistence on otherwise low-risk PTCs.

Methods
Retrospective study including patients with otherwise low-risk PTCs but with vascular invasion, diagnosed between 2013 and 2019. The persistence/recurrence during the follow-up was evaluated. Pathology was reviewed to confirm the presence of lymphovascular invasion and determine the type of invasion.

Results
A total of 141 patients were included. Lymphovascular invasion was confirmed in 20.6%. After surgery, 48.9% (N = 69) of the patients received radioactive iodine (RAI). The median follow-up time was 4 [3–6] years. Overall, 6 (4.2%) patients experienced persistent/recurrent disease in the neck, including 3 with lymphovascular invasion, confirmed as “only lymphatic”. Overall, patients with tumors harboring lymphovascular invasion had sensibly more persistent/recurrence disease compared with those without lymphovascular invasion (10.3% vs 2.7%, p = 0.1), especially in the subgroup of patients not treated with RAI (20% vs 1.6%, p = 0.049) [OR 15.25, 95% CI 1.24-187.85, p = 0.033].

Conclusion
Lymphovascular invasion, including lymphatic invasion only, is associated with a sensibly higher risk of persistent/recurrent disease in otherwise low-risk PTCs, namely in patients not treated with RAI. Lymphatic invasion could have a role in risk-stratification systems for decision making.
Prior Thrombectomy Does Not Affect the Surgical Complication Rate of Decompressive Hemicraniectomy in Patients with Malignant Ischemic Stroke
Authors: Walter Johannes , Alhalabi O. T. , Schönenberger S. , Ringleb P. , Vollherbst D. F. , Möhlenbruch M. , Unterberg A. , Neumann J.-O. 
Published: August 2023

Abstract
Background
Even though mechanical recanalization techniques have dramatically improved acute stroke care since the pivotal trials of decompressive hemicraniectomy for malignant courses of ischemic stroke, decompressive hemicraniectomy remains a mainstay of malignant stroke treatment. However, it is still unclear whether prior thrombectomy, which in most cases is associated with application of antiplatelets and/or anticoagulants, affects the surgical complication rate of decompressive hemicraniectomy and whether conclusions derived from prior trials of decompressive hemicraniectomy are still valid in times of modern stroke care.

Methods
A total of 103 consecutive patients who received a decompressive hemicraniectomy for malignant middle cerebral artery infarction were evaluated in this retrospective cohort study. Surgical and functional outcomes of patients who had received mechanical recanalization before surgery (thrombectomy group, n = 49) and of patients who had not received mechanical recanalization (medical group, n = 54) were compared.

Results
The baseline characteristics of the two groups did significantly differ regarding preoperative systemic thrombolysis (63.3% in the thrombectomy group vs. 18.5% in the medical group, p < 0.001), the rate of hemorrhagic transformation (44.9% vs. 24.1%, p = 0.04) and the preoperative Glasgow Coma Score (median of 7 in the thrombectomy group vs. 12 in the medical group, p = 0.04) were similar to those of prior randomized controlled trials of decompressive hemicraniectomy. There was no significant difference in the rates of surgical complications (10.2% in the thrombectomy group vs. 11.1% in the medical group), revision surgery within the first 30 days after surgery (4.1% vs. 5.6%, respectively), and functional outcome (median modified Rankin Score of 4 at 5 and 14 months in both groups) between the two groups.

Conclusions
A prior mechanical recanalization with possibly associated systemic thrombolysis does not affect the early surgical complication rate and the functional outcome after decompressive hemicraniectomy for malignant ischemic stroke. Patient characteristics have not changed significantly since the introduction of mechanical recanalization; therefore, the results from former large randomized controlled trials are still valid in the modern era of stroke care.
Three-Dimensional Numerical Modeling of Ground Ice Ablation in a Retrogressive Thaw Slump and Its Hydrological Ecosystem Response on the Qinghai-Tibet Plateau, China
Authors: Niu Fujun , Jiao Chenglong , Luo Jing , He Junlin , He Peifeng 
Published: August 2023

AbstractRetrogressive thaw slumps (RTSs), which frequently occur in permafrost regions of the Qinghai-Tibet Plateau (QTP), China, can cause significant damage to the local surface, resulting in material losses and posing a threat to infrastructure and ecosystems in the region. However, quantitative assessment of ground ice ablation and hydrological ecosystem response was limited due to a lack of understanding of the complex hydro-thermal process during RTS development. In this study, we developed a three-dimensional hydro-thermal coupled numerical model of a RTS in the permafrost terrain at the Beilu River Basin of the QTP, including ice–water phase transitions, heat exchange, mass transport, and the parameterized exchange of heat between the active layer and air. Based on the calibrated hydro-thermal model and combined with the electrical resistivity tomography survey and sample analysis results, a method for estimating the melting of ground ice was proposed. Simulation results indicate that the model effectively reflects the factual hydro-thermal regime of the RTS and can evaluate the ground ice ablation and total suspended sediment variation, represented by turbidity. Between 2011 and 2021, the maximum simulated ground ice ablation was in 2016 within the slump region, amounting to a total of 492 m3, and it induced the reciprocal evolution, especially in the headwall of the RTS. High ponding depression water turbidity values of 28 and 49 occurred in the thawing season in 2021. The simulated ground ice ablation and turbidity events were highly correlated with climatic warming and wetting. The results offer a valuable approach to assessing the effects of RTS on infrastructure and the environment, especially in the context of a changing climate.
Corrosion behavior, mechanical properties, and in-vitro biocompatibility of cast Mg–3Zn–xSi biodegradable alloys for bone regeneration
Authors: Safwat Engie M. , Hammam Rania E. , Moussa M. E. , Abdel-Gawad Soha A. , Shoeib Madiha , El-Hadad Shimaa 
Published: August 2023

AbstractIn this research, Mg–3Zn–xSi (x = 0, 0.1, 0.3, and 0.6 wt%) biodegradable alloys were produced by simple stir casting method, their microstructure and phase changes were evaluated using X-ray diffraction (XRD), optical microscope (OM) and scanning electron microscope coupled with energy dispersive x-ray analysis (SEM–EDS). Potentiodynamic polarization was conducted to measure the alloys’ corrosion behavior in simulated body fluid (SBF). Tensile strength test and in-vitro biocompatibility evaluation regarding MTT cytotoxicity, ALP osseointegration assay and MG-63 cell growth pattern were conducted. Electrochemical investigations showed that Mg–3Zn alloys enclosing Si attained degradation rates suitable for structural support until bone healing, while the Mg–3Zn alloy without Si had a corrosion rate of 0.128 mm/year which is much lower than the required value. None of the inspected alloys exhibited a significant cytotoxic effect, meanwhile, Mg–Zn base alloy and the alloy with 0.3 wt% Si demonstrated the highest ALP level. The optimum cell growth pattern was demonstrated for Mg–Zn base alloy and the alloy with 0.1 wt% Si. Evidence of calcium phosphate precipitation was observed in the four investigated Mg–3Zn alloys. Therefore, based on the fore mentioned results, Mg–3Zn–xSi alloys were suggested as viable biodegradable materials due to their compatible degradation rates, proved cytocompatibility, high cell viability and excellent osseointegration potential.
Global Distribution of Electron Temperature Enhancement at Mid‐Low Latitudes Observed by DMSP F16 Satellite
Authors: Liang Jianyun , Xu Jiyao , Zhang Qinghe , Liu Jing , Zhang Yongliang , Zhang Shun‐Rong , Wang Xiangyu , Xing Zanyang , Wu Kun 
Published: August 2023

AbstractThis study investigates the global distribution of electron temperature enhancement observed by Defense Meteorological Satellite Program F16 satellite and its dependence on the season and solar activity for the solar maximum (2014) and minimum (2018) years during geomagnetic quiet times (maximum per day ap <10). Electron temperature enhancements occurred mainly over the North American‐Atlantic (260°–360°E) and Eurasia (0°–160°E) (Southern Oceania (80°–280°E)) sector in the Northern (Southern) Hemisphere and are prominent in the winter hemispheres and solar maximum year. They have obvious longitude characteristics. Interestingly, they could extend to geomagnetic equatorial regions in the North American‐Atlantic sector from high to low latitudes in the December Solstice, further crossed the magnetic equator, and merged into the Southern Hemisphere in 2014, where the maximum temperature reached ∼3500 K. Our analysis indicates that low‐energy electrons (<100 eV) associated with photoelectron from the conjugate sunlit hemisphere, can contribute to these enhancements. Furthermore, the local geomagnetic declination, magnetic equator position, and terminator position at magnetic conjugate points together can impact the global distribution of photoelectrons of different energies and therefore the electron temperature enhancement distribution. Other processes (including local electron density variation) may play certain roles as well.
The Volcanic and Radial Expansion/Contraction History of the Moon Simulated by Numerical Models of Magmatism in the Convective Mantle
Authors: U Ken'yo , Kameyama Masanori , Ogawa Masaki 
Published: August 2023

AbstractTo understand the evolution of the Moon, we numerically modeled mantle convection and magmatism in a two‐dimensional polar rectangular mantle. Magmatism occurs as an upward permeable flow of magma generated by decompression melting through the convecting matrix. The mantle is assumed to be initially enriched in heat‐producing elements (HPEs) and compositionally dense ilmenite‐bearing cumulates (IBC) at its base. Here, we newly show that magma generation and migration play a crucial role in the calculated volcanic and radial expansion/contraction history. Magma is generated in the deep mantle by internal heating for the first several hundred million years. A large volume of the generated magma ascends to the surface as partially molten plumes driven by melt buoyancy; the magma generation and ascent cause a volcanic activity and radial expansion of the Moon with the peak at 3.5–4 Gyr ago. Eventually, the Moon begins to radially contract when the mantle solidifies by cooling from the surface boundary. As the mantle is cooled, the activity of partially molten plumes declines but continues for billions of years after the peak because some basal materials enriched in the dense IBC components hold HPEs. The calculated volcanic and radial expansion/contraction history is consistent with the observed history of the Moon. Our simulations suggest that a substantial fraction of the mantle was solid, and there was a basal layer enriched in HPEs and the IBC components at the beginning of the history of the Moon.
The accuracy of virtual setup in simulating treatment outcomes in orthodontic practice: a systematic review
Authors: Sereewisai Benja , Chintavalakorn Rochaya , Santiwong Peerapong , Nakornnoi Theerasak , Neoh Siew Peng , Sipiyaruk Kawin 
Published: August 2023

Abstract
Objectives
To evaluate the accuracy of virtual orthodontic setup in simulating treatment outcomes and to determine whether virtual setup should be used in orthodontic practice and education.

Materials and Methods
A systematic search was performed in five electronic databases: PubMed, Scopus, Embase, ProQuest Dissertations & Theses Global, and Google Scholar from January 2000 to November 2022 to identify all potentially relevant evidence. The reference lists of identified articles were also screened for relevant literature. The last search was conducted on 30 November 2022.

Results
This systematic review included twenty-one articles, where all of them were assessed as moderate risk of bias. The extracted data were categorized into three groups, which were: (1) Virtual setup and manual setup; (2) Virtual setup and actual outcomes in clear aligner treatment; (3) Virtual setup and actual outcomes in fixed appliance treatment. There appeared to be statistically significant differences between virtual setups and actual treatment outcomes, however the discrepancies were clinically acceptable.

Conclusion
This systematic review supports the use of orthodontic virtual setups, and therefore they should be implemented in orthodontic practice and education with clinically acceptable accuracy. However, high-quality research should be required to confirm the accuracy of virtual setups in simulating treatment outcomes.
Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
Authors: Kim Kiho , Min In Sik , Kim Tae Hee , Kim Do Hyeon , Hwang Seungwon , Kang Kyowon , Kim Kyubeen , Park Sangun , Lee Jongmin , Cho Young Uk , Lee Jung Woo , Yeo Woon-Hong , Song Young Min , Jung Youngmee , Yu Ki Jun 
Published: August 2023

AbstractPhotodynamic therapy (PDT) is attracting attention as a next-generation cancer treatment that can selectively destroy malignant tissues, exhibit fewer side effects, and lack pain during treatments. Implantable PDT systems have recently been developed to resolve the issues of bulky and expensive conventional PDT systems and to implement continuous and repetitive treatment. Existing implantable PDT systems, however, are not able to perform multiple functions simultaneously, such as modulating light intensity, measuring, and transmitting tumor-related data, resulting in the complexity of cancer treatment. Here, we introduce a flexible and fully implantable wireless optoelectronic system capable of continuous and effective cancer treatment by fusing PDT and hyperthermia and enabling tumor size monitoring in real-time. This system exploits micro inorganic light-emitting diodes (μ-LED) that emit light with a wavelength of 624 nm, designed not to affect surrounding normal tissues by utilizing a fully programmable light intensity of μ-LED and precisely monitoring the tumor size by Si phototransistor during a long-term implantation (2–3 weeks). The superiority of simultaneous cancer treatment and tumor size monitoring capabilities of our system operated by wireless power and data transmissions with a cell phone was confirmed through in vitro experiments, ray-tracing simulation results, and a tumor xenograft mouse model in vivo. This all-in-one single system for cancer treatment offers opportunities to not only enable effective treatment of tumors located deep in the tissue but also enable precise and continuous monitoring of tumor size in real-time.
α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies
Authors: Hart de Ruyter Frederique J. , Morrema Tjado H. J. , den Haan Jurre , Gase Gina , Twisk Jos W. R. , de Boer Johannes F. , Scheltens Philip , Bouwman Femke H. , Verbraak Frank D. , Rozemuller Annemieke J. M. , Hoozemans Jeroen J. M. 
Published: August 2023

AbstractThere is increasing interest in studying retinal biomarkers for various neurodegenerative diseases. Specific protein aggregates associated with neurodegenerative diseases are present in the retina and could be visualised in a non-invasive way. This study aims to assess the specificity and sensitivity of retinal α-synuclein aggregates in neuropathologically characterised α-synucleinopathies, other neurodegenerative diseases and non-neurological controls. Post-mortem eyes (N = 99) were collected prospectively through the Netherlands Brain Bank from donors with Parkinson’s disease (and dementia), dementia with Lewy bodies, multiple system atrophy, Alzheimer’s disease, other neurodegenerative diseases and non-neurological controls. Multiple retinal and optic nerve cross-sections were immunostained with anti-α-synuclein antibodies (LB509, KM51, and anti-pSer129) and assessed for aggregates and inclusions. α-Synuclein was observed as Lewy neurites in the retina and oligodendroglial cytoplasmic inclusions in the optic nerve and was highly associated with Lewy body disease (P < 0.001) and multiple system atrophy (P = 0.001). In all multiple system atrophy cases, the optic nerve showed oligodendroglial cytoplasmic inclusions, while retinal Lewy neurites were absent, despite coincidental brain Lewy pathology. With high specificity (97%) and sensitivity (82%), retinal/optic nerve α-synuclein differentiates primary α-synucleinopathies from other cases and controls. α-Synuclein pathology occurs specifically in the retina and optic nerve of primary α-synucleinopathies as opposed to other neurodegenerative diseases—with and without α-synuclein co-pathology—and controls. The absence of retinal Lewy neurites in multiple system atrophy could contribute to the development of an in vivo retinal biomarker that discriminates between Lewy body disease and multiple system atrophy.
Travel distance, frequency of return, and the spread of disease
Authors: Heine Cate , O’Keeffe Kevin P. , Santi Paolo , Yan Li , Ratti Carlo 
Published: August 2023

AbstractHuman mobility is a key driver of infectious disease spread. Recent literature has uncovered a clear pattern underlying the complexity of human mobility in cities: $$r \cdot f$$

r
·
f

, the product of distance traveled r and frequency of return f per user to a given location, is invariant across space. This paper asks whether the invariant $$r\cdot f$$

r
·
f

also serves as a driver for epidemic spread, so that the risk associated with human movement can be modeled by a unifying variable $$r\cdot f$$

r
·
f

. We use two large-scale datasets of individual human mobility to show that there is in fact a simple relation between r and f and both speed and spatial dispersion of disease spread. This discovery could assist in modeling spread of disease and inform travel policies in future epidemics—based not only on travel distance r but also on frequency of return f.
Perceived gender and political persuasion: a social media field experiment during the 2020 US Democratic presidential primary election
Authors: Combs Aidan , Tierney Graham , Alqabandi Fatima , Cornell Devin , Varela Gabriel , Castro Araújo Andrés , Argyle Lisa P. , Bail Christopher A. , Volfovsky Alexander 
Published: August 2023

AbstractWomen have less influence than men in a variety of settings. Does this result from stereotypes that depict women as less capable, or biased interpretations of gender differences in behavior? We present a field experiment that—unbeknownst to the participants—randomized the gender of avatars assigned to Democrats using a social media platform we created to facilitate discussion about the 2020 Primary Election. We find that misrepresenting a man as a woman undermines his influence, but misrepresenting a woman as a man does not increase hers. We demonstrate that men’s higher resistance to being influenced—and gendered word use patterns—both contribute to this outcome. These findings challenge prevailing wisdom that women simply need to behave more like men to overcome gender discrimination and suggest that narrowing the gap will require simultaneous attention to the behavior of people who identify as women and as men.