bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of co‐medications and potential risk factors of high‐dose methotrexate‐mediated acute hepatotoxicity in patients with osteosarcoma
Authors: Wang Sheng‐Fan , Huang Kuan‐Wei , Chou Yueh‐Ching , Lee Hsin‐Chen , Wu Po‐Kuei , Chen Wei‐Ming , Hung Giun‐Yi , Chang Yuh‐Lih 
Published: April 2023

AbstractBackgroundTaiwanese patients frequently experience severe hepatotoxicity associated with high‐dose methotrexate (HD‐MTX) treatment, which interferes with subsequent treatment. Drug–drug interactions occur when MTX is used in combination with proton pump inhibitors (PPIs), trimethoprim‐sulfamethoxazole (TMP‐SMX), or non‐steroidal anti‐inflammatory drugs (NSAIDs). In East Asia, real‐world analyses on the effects of co‐medication and other potential risk factors on the clinical course of HD‐MTX‐mediated acute hepatotoxicity in patients with osteogenic sarcoma (OGS) are limited.MethodsThis cohort study included patients with newly diagnosed OGS who were treated with HD‐MTX between 2009 and 2017 at Taipei Veterans General Hospital. We collected data on the clinical course of HD‐MTX‐mediated acute hepatotoxicity, co‐medications, and other potential risk factors, and analyzed the effects of these factors on the clinical course of HD‐MTX‐mediated acute hepatotoxicity.ResultsAlmost all patients with OGS treated with HD‐MTX developed acute hepatotoxicity with elevated alanine aminotransferase (ALT) levels. Most patients with Grade 3–4 ALT elevation failed to recover to Grade 2 within 7 days. Women and children are high‐risk subgroups for HD‐MTX‐mediated elevation of ALT levels. Age is a factor that contributes to the pharmacokinetic differences of HD‐MTX. However, the concurrent use of PPIs, TMP‐SMX, or NSAIDs did not affect the elimination of MTX when administered with adequate supportive therapy.ConclusionsCo‐administration of PPIs, TMP‐SMX, or NSAIDs may have limited effects on acute hepatotoxicity in well‐monitored and adequately pre‐medicated patients with OGS undergoing chemotherapy with HD‐MTX. Clinicians should pay particular attention to ALT levels when prescribing HD‐MTX to children and women.
Disease progression status during initial immune checkpoint inhibitor (ICI) affects the clinical outcome of ICI retreatment in advanced non‐small cell lung cancer patients
Authors: Torasawa Masahiro , Yoshida Tatsuya , Takeyasu Yuki , Shimoda Yukiko , Tateishi Akiko , Matsumoto Yuji , Masuda Ken , Shinno Yuki , Okuma Yusuke , Goto Yasushi , Horinouchi Hidehito , Yamamoto Noboru , Takahashi Kazuhisa , Ohe Yuichiro 
Published: April 2023

AbstractBackgroundIt is still unclear whether patients with advanced non‐small cell lung cancer (NSCLC), with disease progression after initial immune checkpoint inhibitor (ICI) therapy, would benefit from ICIs readministration.Patients and MethodsWe retrospectively collected data from patients with advanced NSCLC who received ICI retreatment. Depending on the disease status at the discontinuation of the initial ICI therapy, the patients were divided into two groups: with disease progression (PD group) and without disease progression (Without PD group). Patients in the Without PD group were required to experience disease progression during the treatment‐free period. Efficacy was assessed by measuring the objective response rate (ORR) and progression‐free survival in retreatment (PFS‐R), while safety was assessed using the incidence of immune‐related adverse events (irAEs).Results30 (46.7%) of 64 eligible patients were included in the PD group and 34 (53.1%) in the Without PD group. Patients in the Without PD group had better clinical outcomes than those in the PD group (ORR, 29.4% vs. 6.7%; p = 0.03, median PFS‐R, 4.1 months vs. 2.2 months, hazard ratio [HR], 0.61; 95% confidence interval [CI], 0.36–1.04; p = 0.07). Multivariate Cox regression analysis showed that patients in the Without PD group had significantly longer PFS‐R than those in the PD group (HR 0.42, 95% CI, 0.21–0.85; p = 0.015). In terms of safety, 28.1% of patients observed irAEs during ICI retreatment, and the incidence rate of grade 3 or higher irAEs was 7.8%. Specifically, of the 28 patients who discontinued their initial ICI treatment because of irAEs, 35.7% developed irAEs, and 28.6% experienced relapsed irAEs during ICI retreatment.ConclusionImmune checkpoint inhibitor retreatment demonstrated efficacy in patients who discontinued initial ICI therapy for reasons other than disease progression. However, ICI retreatment was ineffective in patients with disease progression during the initial ICI treatment.
Impact of race/ethnicity and language preferences on pediatric ALL survival outcomes
Authors: Davitt Meghan , Gennarini Lisa , Loeb David , Fazzari Melissa , Hosgood H. Dean 
Published: April 2023

AbstractBackgroundEthnic and racial disparities have recently been observed both in treatment‐related toxicities and rates of long‐lasting cure in acute lymphoblastic leukemia (ALL) and acute lymphoblastic lymphoma (ALLy), the most common pediatric malignancy. Despite significant improvements in overall survival in the recent past, a large number of children die from aggressive disease.MethodsWe performed a retrospective cohort analysis of 274 pediatric ALL/ALLy patients within Montefiore Health System from 2004 to 2021 to determine differences in all‐cause mortality within the Pediatric Hematologic Malignancies Cohort using Cox Proportional Hazard regression modeling, adjusted for age at diagnosis, race/ethnicity, administration of intensive chemotherapy, preferred language, maximum glucose, and hypertension.ResultsAmong our 274 patients, 132 were Hispanic, 54 Non‐Hispanic Black, and 25 Non‐Hispanic White, with 25 identified as “Non‐Hispanic Other,” including Asian, Arabic, and Other. Hispanic patients were 78% less likely to die (HR 0.22; 95% CI 0.07, 0.73) when compared with Non‐Hispanic Black individuals. Spanish speakers were 2.91 times more likely to die compared with those who spoke English (HR 2.91; 95% CI 1.08, 7.82). Among those English speakers, the diagnosis of hypertension and Hispanic ethnicity significantly impacted the risk of death, while these factors did not impact survival in Spanish speakers. High‐risk cytogenetics did not impact survival.ConclusionsHispanic children with ALL/ALLy have improved survival outcomes compared with Non‐Hispanic Blacks. Additionally, Spanish language preference was strongly associated with poorer survival, a novel finding that should be validated in future studies.
Heterogeneity in intracranial relapses after complete resection of lung adenocarcinoma: Distinct features of brain‐only relapse versus synchronous extracranial relapse
Authors: Xu Fei , Li Junling , Xing Puyuan , Liu Yutao , Wang Yan 
Published: April 2023

AbstractBackgroundPatients with brain oligometastases have better prognosis than those with synchronous extracranial metastases in non‐small cell lung cancer (NSCLC). However, studies focusing on intracranial‐only recurrence after curative surgery remained scarce. This study aimed to explore distinct features of patients with exclusive brain relapse after resection of lung adenocarcinoma.MethodsRecords were retrospectively reviewed of 2809 patients who had complete resection and pathologically confirmed stage IB‐IIIA NSCLC in our hospital from October 2012 to September 2019. Patients were enrolled if they were adenocarcinoma and developed intracranial recurrence thereafter. They were divided into two groups depending on whether they had synchronous extracranial metastases. Clinical and pathological features of patients enrolled were collected and compared between groups.ResultsNinety‐seven lung adenocarcinoma patients with intracranial recurrences were enrolled. The median follow‐up time was 40 months. Fifty patients (51.5%) had brain oligometastases and 47 patients had synchronous extracranial metastases (ECM). Multivariate logistic regression suggested EGFR‐sensitive mutation and male sex were positively correlated to brain‐only recurrence (OR = 2.59, 95%CI 1.04–6.84 and OR = 2.58, 95% CI 1.05–6.75), while higher clinical stage was associated with synchronous ECM (stage II (OR = 0.33, 95%CI 0.09–1.14) or stage IIIA (OR = 0.54, 95%CI 0.20–1.38) versus stage I). No other pathological feature (lymphovascular invasion, visceral pleural invasion, low tumor differentiation, etc.) or adjuvant chemotherapy was associated with intracranial‐only relapse after complete resection of primary tumor.ConclusionAmong patients with brain relapse after resection of lung adenocarcinoma, patients with EGFR mutations might have intracranial relapse only without synchronous extracranial metastases. Further prospective studies are warranted to verify this.
Lowering air kerma to improve the CTO operator's karma
Authors: Rigattieri Stefano , Casenghi Matteo 
Published: April 2023

Key Points
Along with the implementation of protection devices and procedural techniques, optimizing fluoroscopic protocols is a crucial step to reduce radiation dose to cath‐lab operators
According to this retrospective study, using an ultra‐low dose fluoroscopy protocol (3.75 frames per second) is a simple, effective, and safe way to reduce radiation exposure during chronic total occlusion‐percutaneous coronary intervention
Low dose fluoroscopy protocols should be implemented in clinical practice as long as image quality and procedural success rate are not affected
Cutting balloon for femoral arterial and venus obstructions due to suture‐based closure devices: Case series
Authors: Merdler Ilan , Bernardo Nelson L. , Ben‐Dor Itsik , Waksman Ron 
Published: April 2023

AbstractSuture‐based vascular closure devices have been shown to be effective in hemostasis for procedures with vascular access. However, iatrogenic vascular occlusion may occur. The cutting balloon (CB) is a noncompliant balloon wrapped with 3–4 microsurgical blades that are intended to modify vascular lesions, but it may also be utilized to cut and release endovascular sutures. We report two cases in which the CB was employed as a bailout strategy to alleviate suture‐related vascular occlusion after transcatheter aortic valve replacement. The CB can be effectively utilized to resolve suture‐related vascular occlusion.
Potential of publicly available Beta vulgaris germplasm for sustainable sugarbeet improvement indicated by combining analysis of genetic diversity and historic resistance evaluation
Authors: Tehseen Muhammad Massub , Poore Rachael Claire , Fugate Karen K. , Bolton Melvin D. , Ramachandran Vanitharani , Wyatt Nathan A. , Li Xuehui , Chu Chenggen 
Published: April 2023

AbstractSugar beet (Beta vulgaris L. ssp. vulgaris Doell.) was originally selected from white fodder beet in the 1780s and was then specifically bred for sucrose production. The relatively recent inception of the crop has led to a narrow genetic base that has bottlenecked sustainable improvement. To evaluate the potential of publicly available germplasm for sugar beet improvement, genetic diversity analysis with SNPs (single‐nucleotide polymorphisms) covering the whole genome of sugar beet was conducted using 1936 publicly available germplasm lines in the United States. The results confirmed the narrow genetic base of sugar beet and identified germplasm accessions with inherently greater diversity that were mostly accessions of wild sea beet (B. vulgaris ssp. maritima (L.) Arcang.), the progenitor species of white fodder beet. These wild accessions displayed a distinct genetic relationship from cultivated sugar beet lines, indicating their high potential for broadening sugar beet genetic diversity. Analysis of historic resistance evaluations also suggested a higher potential of B. vulgaris ssp. maritima accessions to be used as sources of resistance to major diseases and insects of sugar beet. A genome‐wide association study using historic evaluation data identified genomic regions significantly associated with disease and insect resistance. However, genomic regions associated with resistance to nematode, insects, or diseases vectored by insects were of low significance, indicating the need for additional research to allow for a more precise evaluation of germplasm responses to insects. The research confirms that accessions of B. vulgaris ssp. maritima are potentially valuable for improving biotic stress resistance and broadening the genetic base of sugar beet.
Harvest aids did not advance maturity of non‐shatter pennycress
Authors: Cubins Julija A. , Wells Samantha , Gesch Russ W. , Johnson Gregg A. , Walia Maninder K. , Chopra Ratan , Marks M. David , Swenson Rebecca D. , Frels Katherine 
Published: April 2023

AbstractReliance on summer annual crops in the Upper Midwest results in fallow land from late fall through early spring, providing opportunities to integrate winter crops, such as pennycress (Thlapsi arvense L.), onto the landscape. Pennycress agronomics have primarily been studied using unimproved wild‐type lines prone to seed shatter, resulting in significant yield loss if not harvested early. However, high plant and seed moisture complicates harvest and seed storage. A new breeding line with a reduced‐shatter mutation made it possible to use harvest aids to reduce plant moisture without the risk of seed loss. The objectives of this study were to quantify the reduction in pennycress seed and biomass moisture after applying a harvest aid and to assess the seed yield, oil content, and crude protein of the reduced‐shatter line. This study was conducted over the 2018–2019 and 2019–2020 growing seasons with ‘“IO217” pennycress in Rosemount, MN. Seed moisture decreased to a similar level by harvest maturity regardless of treatment while swathing was the most effective method of reducing biomass moisture. Natural senescence decreased pennycress moisture content to a harvestable level at the same rate as treated plants, indicating that a harvest aid is not required at this time. Seed yield was two to six times higher than in studies using unimproved pennycress lines. Challenges associated with wild‐type pennycress lines, such as uneven germination and late maturation, were prevalent in this study and further genetic improvement will be necessary to ensure successful pennycress production in the Upper Midwest.
MIF is essential to the establishment of house dust mite‐induced airway inflammation and tissue remodeling in mice
Authors: Lintomen Leticia , Kluppel Luciana M. , Kitoko Jamil Z. , Montes‐Cobos Elena , Vidal Vinícius M. , Tan Luis B. , de Farias José Nazioberto , de Souza Heitor S. , Olsen Priscilla C. , Bozza Marcelo T. 
Published: April 2023

AbstractMacrophage migration inhibitory factor (MIF) is present in high amounts in the BALF and serum of asthmatic patients, contributing to the pathogenesis of experimental asthma induced by OVA in mice. Whether MIF contributes to the physiopathology on a more complex and relevant asthma model has not been characterized. Mif‐deficient (Mif−/−) or WT mice treated with anti‐MIF antibody were challenged multiple times using house dust mite (HDM) extract by the intranasal route. HDM‐challenged Mif−/− mice presented decreased airway hyperresponsiveness, lung infiltration of eosinophils, mucus hypersecretion, and subepithelial fibrosis compared to HDM‐challenged WT mice. Amounts of IL‐4, IL‐5, and IL‐13 were decreased in the lungs of Mif−/− mice upon HDM challenges, but the increase of CCL11 was preserved, compared to HDM‐challenged WT mice. We also observed increased numbers of group 2 innate lymphoid cells and Th2 cells in the BALF and mediastinal LNs (mLN)‐induced challenged by HDM of WT mice, but not in HDM‐challenged Mif−/− mice. Anti‐MIF treatment abrogated the airway infiltration of eosinophils, mucus hypersecretion, and subepithelial fibrosis in the lungs of HDM‐challenged mice. In conclusion, MIF ablation prevents the pathologic hallmarks of asthma in HDM‐challenged mice, reinforcing the promising target of MIF for asthma therapy.
Evaluation of compositional models and PVT correlations for Iraqi light crude oils properties
Authors: Farkha Sarhad A. , Zangana Mohammed H. S. , Shoham Ovadia 
Published: April 2023

AbstractEvaluation of common compositional models and pressure–volume–temperature (PVT) correlations are carried out against field data for light crude oil from north Iraqi reservoirs. The reported data and the evaluation are significant to the petroleum industry, as various international and local oil companies operate in this region. The comprehensive PVT program Multiflash™ 7.2 is utilized, employing the Peng–Robinson (PR) and Redlich–Kwong–Soave (RKS). The oil formation volume factor, bubble point pressure, solution gas–oil ratio (Rso), and saturated oil viscosity are chosen for this evaluation. The results demonstrate that the PR and RKS compositional models, with some adjustments, exhibit much higher accuracy as compared to PVT correlations. For example, the errors between the model's predictions and the field data for the Rso are 9% for PR ad 17% for the RKS model. In contrast, for the PVT correlations, much higher errors are obtained. The lowest errors (32%) are obtained with the Ikiensikimama and Ajienka, while above 90% errors (the highest) are reported by Petrosky and Farshad. This study will enable the petroleum industry to improve and optimize the production operations in north Iraq–Kurdistan region.
Short‐term load forecasting based on a generalized regression neural network optimized by an improved sparrow search algorithm using the empirical wavelet decomposition method
Authors: Fan Guo‐Feng , Li Yun , Zhang Xin‐Yan , Yeh Yi‐Hsuan , Hong Wei‐Chiang 
Published: April 2023

AbstractWith the development of the electric market, electric load forecasting has been increasingly pursued by many scholars. Because the electric load is affected by many factors, it is characterized by volatility and uncertainty, and it cannot be forecasted accurately only by a single model. In the research, a short‐term load forecasting integrated model is proposed to solve the problem of inaccurate forecasting of a single model. The key point of using the integrated model to forecast is to optimize the decomposed sequence to improve the accuracy of the forecast. empirical wavelet decomposition (EWT) is used to decompose the sequence into stationary sequences and avoid modal aliasing; the sparrow search algorithm (SSA) simulates the forecasting and anti‐forecasting behavior of the sparrow population, which is very similar to the electricity consumption behavior of various industries and has good optimization effect; generalized regression neural network (GRNN) is used for forecast and reconstruction; This is the EWT‐SSA‐GRNN model. This paper studies and analyzes the power load of a city in southern Australia. The results show that the integrated model reduces volatility through decomposition and optimization, and can improve forecast accuracy.
Prediction of the stability of gob‐side entry formation by roof cutting by machine learning‐based models
Authors: Gao Yubing , Gai Qiukai , Xi Xun , Zhang Xingxing , He Manchao 
Published: April 2023

AbstractGob‐side entry formation by roof cutting is a new technology for no pillar coal mining, which can maximize coal resources and reduce roadway drivage ratio. However, the mechanical behavior of the formed entry is complex while it is crucial to ensure the stability of the entry for mining safety. This paper proposed a machine learning‐based method for predicting the stability of the formed entry, which combined artificial neural network (ANN) with particle swarm optimization (PSO) algorithm or genetic optimization (GO) algorithm. The data set from 75 coal mining faces from 2009 to 2022 was employed to train and test the models. A descriptive variable of dynamic unstable distance was introduced to evaluate the stability state of the formed entry and six other parameters were chosen as influence parameters. The two intelligent models were compared with each other to have a comprehensive assessment. Model assessment indices such as R2, mean absolute error, mean absolute percentage error, and root mean square error were used to evaluate the accuracy of the models. The results of both developed models are promising, and the predictive accuracy of the PSO‐ANN model is higher than that of the GO‐ANN model. Through sensitivity analyses, it has been found that the coal seam thickness and roof rock hardness are the most important parameters for influencing entry stability. The developed method provides a practical tool for the prediction of entry stability and the optimization of entry design.
Total‐factor generation performance analysis of China's thermal power industry using meta‐frontier nonradial distance function approach
Authors: Meng Ming , Pang Tingting 
Published: April 2023

AbstractThermal power is the main source of China's electricity supply. Improving total‐factor generation performance (TFGP) is essential for the development of this industry in the current deteriorating operating environment. This study adopts the meta‐frontier nonradial direction distance function approach to measure the static and dynamic TFGPs of the thermal power industry in China's 30 provinces in 2011–2019, and then discusses the regional distribution characteristics and the impact factors using spatial econometric model and Tobit regression method, respectively. Empirical results show that: (I) The TFGPs in central and west China are relatively close, but both are remarkably lower than that in east China. (II) The TFGPs in central and west China have generally remained stable since 2011, whereas that in west China has declined mainly because this region is more susceptible to the situation of electricity supply‐demand. (III) A significant spatial positive correlation exists among provincial TFGPs. High TFGP provinces are mostly in the eastern seaboard region and low TFGP provinces are in southwest China. (IV) Economic development, power structure, fuel prices, and environmental regulation have positive impacts on China's TFGP, while the impacts of technological innovation and energy endowment are not significant.
A tale of two contracts: Examining the behavior of bid–ask spreads of corn futures in China
Authors: Li Miao , Xiong Tao , Li Ziran 
Published: April 2023

AbstractContracts that expire in January, May, and September attract the most trading activity for corn futures in China. Contracts that mature in other months are thinly traded, even when they are the closest to maturity. In this paper, we examine and compare the behavior and determinants of the bid–ask spreads (BASs) of active and inactive contracts using the best bid offer data set. We show that both the magnitude and volatility of BAS for inactive contracts exhibit U‐shaped patterns, whereas active contracts' BAS increase only near their expiration. Inactive contracts are also of low liquidity risk after introducing market makers. On the basis of the simultaneous equation model, we find that BAS responds negatively to volume and positively to volatility and order imbalance. The impacts are larger in inactive contracts. Moreover, introducing market makers to inactive contracts is conducive to attracting trading and lowering trading costs.