bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kebijakan Pengembangan Pariwisata Melalui Ajang Mojang Jajaka Sebagai Duta Pariwisata
Authors: Amalia Nadia , Ruslyandi  
Published: April 2023

Kabupaten Bogor merupakan salah satu daerah tujuan wisata di Indonesia karena memiliki banyak potensi wisata, seperti wisata alam, wisata budaya, dan lain-lain. Dinas Pariwisata dan Kebudayaan melibatkan para Mojang Jajaka ini menemani dalam setiap kegiatan pemerintahan serta membantu dalam mempromosikan pariwisata atau soal lingkungan hidup, dimana pariwisata dan kebudayaan menjadi salah satu PAD di Kabupaten Bogor. Penelitian ini diharapkan dapat merumuskan model pengembangan parawisata melalui ajang Mojang Jajaka atau model implementasi kebijakan dalam rangka pengembangan ilmu Khusus terkait kebijakan public. Metode yang digunakan kualitatif murni dimana peneliti terlibat langsung dalam penelitian tsb. Teori yang dipakai dalam penelitian ini Edward III Komunikasi, Sumber daya, Disposisi, Implementasi dan Struktur birokrasi. Komunikasi yang dimaksud dalam penelitian ini kebijakan Pariwisata dan kebudayaan Kabupaten Bogor mensosialisasikan tentang tujuan implementasi kebijakan Dinas Pariwisata Kabupaten Bogor Budaya Mewujudkan sumberdaya manusia didak luput dari peran menajemen terdiri dari kegiatan pengaturan perencanaan, pengorganisasian, pengarahan. Sarana manajemen menurut Harrington Emerson dalam Phiffner John (1960) mempunyai lima unsur (5M) yaitu: Men, Money, Materials, dan methods. Kecenderungan atau sikap dalam implementasi kebijakan berperan penting dalam suksesnya kebijakan, karena itu pelaksana kebijakan pariwisata yang tercantum dalam Undang-undang Nomor 10 Tahun 2009 didasarkan pada sikap dan pandangan yang dimiliki. Proses yang ada dalam birokrasi dapat berjalan jika konsisten, efisien dan efisien sehingga tidak bertentangan dengan peraturan- peraturan yang ada birokrasi menjadi 2 SOP dan Penyebaran Tanggung Jawab dalam Konteks Implementasi Kebijakan pengembangan ara wisata dalam ajang Mojang Jajaka.
Pelaksanaan program imunisasi BCG terhadap partisipasi masyarakat di Posyandu Seroja
Authors: Lubis Yusuf Hanafi 
Published: April 2023

The Directorate of Disease Prevention and Control, Ministry of Health of the Republic of Indonesia shows that 1.7 million children have not received complete immunization from 2014 to 2016. (Objective) This study aims to determine the effect of community participation on the implementation of the BCG immunization program at Posyandu Seroja. (Methods) using a quantitative approach with a cross-sectional research design by taking a sample of 40 people, namely all parents of toddlers who came to the Seroja posyandu in total sampling by conducting interviews using questionnaires to obtain information related to the implementation of the BCG immunization program, data were analyzed univariately, bivariately and multivariately to obtain crude values and adjusted oods ratio. (Results) shows that community participation in Posyandu is 50%. There is a significant relationship between public invitation to join the Posyandu program and the implementation of the BCG vaccination program (p-value; 0.032(<0.05), AOR; 2.049, 95%CI;4.95-8.48). (Conclusion) is factors that can affect the running of the BCG immunization program at Posyandu Seroja with a precision value of 5% are inviting people to participate in posyandu, inviting other parents to come to the posyandu and babies have been immunized against BCG.
Analisi Faktor Faktor Yang Mempengaruhi Tingkat Partisipasi Angkatan Kerja (TPAK) Wanita Di Rokan Hilir
Authors: Haryanti Sri 
Published: April 2023

Tingkat Partisipasi Angkatan Kerja (TPAK) wanita merupakan hubungan antara tingkat penduduk yang berkerja pada Tingkat Pendidikan Wanita bekerja dalam pasar tenaga kerja. Penelitian ini bertujuan untuk melihat pengaruh PDRB, Upah Minimum, Tingkat Pendidikan Wanita bekerja tamatan SMU sederajat dan Tingkat Pendidikan Wanita bekerja tamatan Diploma Keatas terhadap TPAK wanita di Rokan Hilir. Jenis penelitian yang digunakan ialah penelitian deskriptif kuantitatif. Data yang diolah adalah data Publikasi Badan Statistik berupa data TPAK wanita, PDRB, Upah Minimum, Tingkat Pendidikan Wanita bekerja tamatan SMU sederajat dan Tingkat Pendidikan Wanita bekerja tamatan Diploma Keatas Tahun 2012-2021. Teknis analisis yang digunakan dalam penelitian ini adalah analisis regersi linear berganda. Berdasarkan hasil penelitian diperoleh nilai cofisien regersi variabel PDRB 1.94E-10 dengan tingkat signigikan 0.0458 dan disimpulkan bahwa PDRB berpengaruh positif dan signifikan terhadapa TPAK Wanita. Sedangkan nilai cofisien regersi variabel Upah Minimum -0.920910 dengan tingkat signifikan 0. 0439 dan disimpulkan bahwa Upah Minimum berpengaruh negatif dan signifikan terhadap TPAK wanita. Sedangkan nilai cofisien regersi variabel Tingkat Pendidikan Wanita bekerja tamatan SMU sederajat 0.003446 dengan tingkat signifikan 0.0064 dan disimpulkan bahwa Tingkat Pendidikan Wanita bekerja tamatan SMU sederajat berpengaruh positif dan signifikan terhadap TPAK Wanita. Adapun nilai Tingkat Pendidikan Wanita bekerja tamatan Diploma Keatas 0.064641 dengan tingkat signifikan 0.6221 dan disimpulkan bahwa Tingkat Pendidikan Wanita bekerja tamatan Diploma Keatas berpengaruh positif dan tidak signifikan terhadap TPAK Wanita.
Kata Kunci: TPAK Wanita, PDRB, Upah Minimum, Tingkat Pendidikan Wanita Bekerja Tamatan SMU Sederajat dan Tingkat Pendidikan Wanita Bekerja Tamatan Diploma Keatas.
Coaching psicogénico: Una posibilidad a la crisis en el enfoque psicoterapéutico tradicional
Authors: Ahumada Francisco 
Published: April 2023

La psicología actual se enfrenta a desafíos que tienen características particulares. Estos desafíos tienen que ver con la inmediatez, la alienación y la construcción de un sentido exitista de la vida. El problema es que estas necesidades actuales siguen siendo tratadas con una psicología con bases epistemológicas y psicológicas obsoletas. Necesitamos reconocer esta crisis. Este artículo se enfoca en ofrecer una posibilidad de reflexión y especialización para los psicoterapeutas y la psicología en general, en la búsqueda de volverse más atingentes a los desafíos que enfrentan en su quehacer actual. Propone la necesidad de declarar crisis en los fundamentos filosóficos, los paradigmas, los enfoques y las técnicas que dan base a la psicoterapia tradicional. En el desarrollo del artículo se presenta unadisciplina complementaria recientemente creada llamada coaching psicogénico. Se muestran sus características principales y generales. Por último, se desglosan ciertas premisas éticas importantes para adoptar en la actualidad e incrementar la efectividad y credibilidad de la psicología.
A Review of Clinical Laboratory Education, Training and Progression: Historical Challenges, the Impact of COVID-19 and Future Considerations
Authors: Pearse Claudia , Scott Sheri 
Published: April 2023

The COVID-19 pandemic had a wide global impact on society, including the clinical laboratory workforce. This historically underrepresented group of highly skilled professionals have now started to gain the attention they deserve. There had already been dramatic changes to laboratory training over the past 2 decades resulting from advances in technology, changes to service needs, and as a consequence of Pathology reform initiatives. The pandemic has had an additional impact. Higher education institutions and students adapted to emergency remote teaching. Clinical laboratories faced unprecedented challenges to meet COVID-19 testing demands and adjust to new ways of working whilst maintaining their usual high quality service provision. Training, assessment, and development arrangements had to convert to online platforms to maintain social distancing. The pandemic also had a global impact on mental health and wellbeing, further impacting learning/training. Despite these challenges, there have been many positive outcomes. This review highlights pre- and post-pandemic training and assessment for clinical laboratory professionals, with particular emphasis on Biomedical Scientists, outlining recent improvements among a history of challenges. There is increasing interest surrounding this vital workforce, accelerated thanks to the pandemic. This new public platform has emphasised the importance of quality diagnostic services in the patient pathway and in the response to national crises. The ability to maintain a quality service that is prepared for the future is grounded in the effective training and development of its staff. All of which can only be achieved with a workforce that is sustainable, invested in, and given a voice.
Molecular modeling, simulation and docking of Rv1250 protein from Mycobacterium tuberculosis
Authors: Choudhary Sumita , Kesavan Anup Kumar , Juneja Vijay , Thakur Sheetal 
Published: April 2023

Computational prediction and protein structure modeling have come to the aid of various biological problems in determining the structure of proteins. These technologies have revolutionized the biological world of research, allowing scientists and researchers to gain insights into their biological questions and design experimental research much more efficiently. Pathogenic Mycobacterium spp. is known to stay alive within the macrophages of its host. Mycobacterium tuberculosis is an acid-fast bacterium that is the most common cause of tuberculosis and is considered to be the main cause of resistance of tuberculosis as a leading health issue. The genome of Mycobacterium tuberculosis contains more than 4,000 genes, of which the majority are of unknown function. An attempt has been made to computationally model and dock one of its proteins, Rv1250 (MTV006.22), which is considered as an apparent drug-transporter, integral membrane protein, and member of major facilitator superfamily (MFS). The most widely used techniques, i.e., homology modeling, molecular docking, and molecular dynamics (MD) simulation in the field of structural bioinformatics, have been used in the present work to study the behavior of Rv1250 protein from M. tuberculosis. The structure of unknown TB protein, i.e., Rv1250 was retrived using homology modeling with the help of I-TASSER server. Further, one of the sites responsible for infection was identified and docking was done by using the specific Isoniazid ligand which is an inhibitor of this protein. Finally, the stability of protein model and analysis of stable and static interaction between protein and ligand molecular dynamic simulation was performed at 100 ns The designing of novel Rv1250 enzyme inhibitors is likely achievable with the use of proposed predicted model, which could be helpful in preventing the pathogenesis caused by M. tuberculosis. Finally, the MD simulation was done to evaluate the stability of the ligand for the specific protein.
Association of myocardial iron deficiency based on T2* CMR with the risk of mild left ventricular dysfunction in HIV-1-infected patients
Authors: Yan Chengxi , Li Ruili , Zhang Jiannan , Zhang Li , Yang Minglei , Zhang Qiujuan , Li Hongjun 
Published: April 2023

ObjectivesThis study sought to noninvasively determine myocardial iron levels in HIV-1-infected patients using CMR and explore the association between T2* values and mild left ventricular systolic dysfunction (LVSD).MethodsThis prospective study was conducted from June 2019 to July 2021. HIV-1-infected adults and healthy controls were consecutively enrolled for CMR exam. CMR exam included the assessment of myocardium iron content (T2*), cardiac function (cine), inflammation (T2), and fibrosis (through extracellular volume fraction [ECV] and late gadolinium enhancement [LGE]) measurements. Mild LVSD is defined as a left ventricular ejection fraction (LVEF) between 40% and 49%.ResultsOf 47 HIV-1-infected patients enrolled, 12 were diagnosed with mild LVSD (HIV-1+/LEVF+) and 35 were diagnosed with preserved LV function (HIV-1+/LEVF−). Compared with healthy controls, HIV-1-infected patients displayed higher T2*, T1, T2, ECV values and lower global circumferential strain (GCS) and global radial strain (GRS) (all P &lt; 0.05). However, between patients with and without mild LVSD, only the T2* values and ECV (all P &lt;0.05) were different. The association between increased T2* values (&gt;26 ms) and mild LVSD remained significant after adjusting for the established univariate predictors (ECV &gt;32.9%, T1 values &gt;1336 ms) of mild LVSD (odds ratio [OR], 10.153; 95% confidence interval [CI] 1.565–65.878, P = 0.015).ConclusionsMyocardial T2* values were elevated in HIV-1-infected patients, supporting the notion that ID was associated with mild LVSD. Our findings highlight the potential for ID in HIV-1-infected patients as an auxiliary biomarker to monitor the course of LVSD.
The association of apolipoprotein B with chronic kidney disease in the Chinese population
Authors: Xu Yu , Liu Bo , Lin Lijin , Lei Fang , Sun Tao , Zhang Xingyuan , Song Xiaohui , Huang Xuewei , Zeng Qiang , Cai Jingjing , Wang Zhifang , Li Hongliang 
Published: April 2023

BackgroundWhether serum apolipoprotein B (ApoB) is a risk factor for the development of Chronic kidney disease (CKD) has not been fully established in the general population. Therefore, our study evaluated the correlation between serum ApoB level and CKD to look for an alternative approach for CKD prevention and treatment in the general population.MethodsThere were 146,533 participants in this cross-sectional study. 3,325 participants with more than 2 measurements were enrolled in the retrospective longitudinal study with at least a 3-year follow-up. ApoB was measured by the immunoturbidimetric method in 6 centers. Our study defined CKD as an estimated glomerular filtration rate (eGFR) &lt; 90 mL/min/1.73 m2. The Spearman rank correlation analysis and the Random Forest algorithm were applied to rank the importance of variables determining the levels of eGFR. We used the logistic regression model to explain the correlation between serum ApoB and CKD. We used the Cox model to detect the correlation between baseline serum ApoB and the subsequent occurrence of CKD.ResultsBased on a cross-sectional study, 66.5% of the participants were males, with a median age of 49 (interquartile range [IQR] 43-55). Compared to the non-CKD group, the CKD group has higher levels of lipid profile and fasting glucose as well as the proportion of hypertension and hyperuricemia. The Spearman rank correlation analysis and the Random Forest algorithm revealed that ApoB has the highest correlation with eGFR decline among lipid profiles. The logistic regression analysis revealed that ApoB had a positive correlation with the prevalence of CKD after fully controlling confounders (odds ratio [OR], 1.07; 95% confidence interval [CI]: 1.02-1.11). Moreover, baseline ApoB level was correlated with a new-onset CKD in the longitudinal cohort after full adjustment for confounding factors (hazard ratio [HR], 1.61; 95% CI: 1.02-2.54). The correlation between ApoB level and the new-onset CKD was consistently observed in all sensitivity analyses.ConclusionSerum ApoB had the strongest correlation with CKD among all lipid variables. Moreover, high serum ApoB levels might precede the occurrence of CKD, suggesting that monitoring and reducing serum ApoB levels may provide an alternative method to prevent and treat CKD.
Blood glucose level affects prognosis of patients who received intravenous thrombolysis after acute ischemic stroke? A meta-analysis
Authors: Wang Yue , Jiang Guannan , Zhang Jie , Wang Jingfeng , You Wanchun , Zhu Juehua 
Published: April 2023

Background and objectivesIntravenous recombinant tissue plasminogen activator (rtPA) thrombolysis is an effective treatment for acute ischemic stroke. Hyperglycemia is a major risk factor for the occurrence, development, and prognosis of ischemic stroke. This meta-analysis purposefully estimates the association between hyperglycemia and poor prognosis in acute ischemic stroke patients receiving intravenous rtPA thrombolytic therapy.Materials and methodsAccording to the predefined inclusion criteria, we searched PubMed, Web of Science, and Cochrane Library databases. The association of high blood glucose(&gt;140mg/dl) with symptomatic intracranial hemorrhage (sICH), poor clinical outcome and mortality at 90 days post-rtPA thrombolysis was studied using both a common effects model and a random effects model. Odds ratios (ORs) were plotted on forest plots.ResultsOf a total cohort of 2565 patients who received intravenous thrombolytic therapy, 721 had higher blood glucose. High glucose level significantly increased the odds of sICH (OR 1.80; 95% confidence interval(95%CI): 1.30- 2.50) and poor clinical outcome at 90 days (OR 1.82; 95%CI: 1.52-2.19), and all-cause mortality at 90 days (OR 2.51; 95%CI:1.65-3.82).ConclusionsIn our meta-analysis, high blood glucose was significantly associated with sICH, poor clinical outcome and higher mortality at 90 days.
Fatty liver mediates the association of hyperuricemia with prediabetes and diabetes: a weighting-based mediation analysis
Authors: Basnet Til Bahadur , Du Shanshan , Feng Ruimei , Gao Jie , Gong Jiamin , Ye Weimin 
Published: April 2023

BackgroundFatty liver, obesity, and dyslipidemia are associated with prediabetes or diabetes risk, and hyperuricemia co-exists. The present study evaluated the role of multiple mediators, namely, fatty liver, body mass index (BMI), and dyslipidemia, in the association between hyperuricemia and diabetes status.MethodsBaseline data from the ongoing Fuqing cohort (5,336 participants) were analyzed to investigate the association of hyperuricemia with diabetes status using a multinomial logistic regression model. Furthermore, causal mediation analysis with the weighting-based approach was performed to estimate hyperuricemia’s total natural direct effect (tnde), total natural indirect effect (tnie), and total effect (te) on prediabetes and diabetes risk, mediating jointly via fatty liver, BMI, and dyslipidemia.ResultsIn multinomial analysis without considering mediators’ effects, hyperuricemia was associated with a higher risk of prediabetes only (odds ratio: 1.25; 95% CI: 1.09–1.43; p &lt; 0.001). When fatty liver, BMI, and dyslipidemia were considered as multiple mediators in the association, hyperuricemia was linked to both prediabetes [tnde: 1.11, 95% CI: 1.04–1.11; tnie: 1.07, 95% CI: 1.05–1.09; and overall proportion mediated (pm): 42%, 95% CI: 27%–73%] and diabetes risk (tnde: 0.96, 95% CI: 0.82–1.14; tnie: 1.25, 95% CI: 1.18–1.33; and pm: 100%, 95% CI: 57%–361%). Hyperuricemia showed significant tnde, te, and tnie, mediated by fatty liver jointly with dyslipidemia (pm = 17%) or BMI (pm = 35%), on prediabetes risk.ConclusionHyperuricemia could increase prediabetes or diabetes risk, partially mediated by fatty liver, BMI, and dyslipidemia. Fatty liver is the crucial mediator in the association between hyperuricemia and prediabetes.
CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction
Authors: Hueso Luisa , Marques Patrice , Morant Brenda , Gonzalez-Navarro Herminia , Ortega Joaquin , Real José T. , Sanz María J , Piqueras Laura 
Published: April 2023

Background/AimsChemokines are known to play critical roles mediating inflammation in many pathophysiological processes. The aim of this study was to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in human morbid obesity.MethodsCirculating levels of CCL17 and CCL22 were measured in 60 morbidly obese patients (mean age, 45 ± 1 years; body mass index/BMI, 44 ± 1 kg/m2) who had undergone bariatric bypass surgery, and 20 control subjects. Paired subcutaneous (SCAT) and visceral adipose tissue (VCAT) from patients were analysed to measure expression of CCR4 and its ligands by RT-PCR, western blot and immunohistochemical analysis. The effects of CCR4 neutralization ex vivo on leukocyte-endothelial cells were also evaluated.ResultsCompared with controls, morbidly obese patients presented higher circulating levels of CCL17 (p=0.029) and CCL22 (p&lt;0.001) and this increase was positively correlated with BMI (p=0.013 and p=0.0016), and HOMA-IR Index (p=0.042 and p&lt; 0.001). Upregulation of CCR4, CCL17 and CCL22 expression was detected in VCAT in comparison with SCAT (p&lt;0.05). Using the parallel-plate flow chamber model, blockade of endothelial CCR4 function with the neutralizing antibody anti-CCR4 in morbidly obese patients significantly reduced leucocyte adhesiveness to dysfunctional endothelium, a key event in atherogenesis. Additionally, CCL17 and CCL22 increased activation of the ERK1/2 mitogen-activated protein kinase signalling pathway in human aortic endothelial cells, which was significantly reduced by CCR4 inhibition (p=0.016 and p&lt;0.05).ConclusionBased on these findings, pharmacological modulation of the CCR4 axis could represent a new therapeutic approach to prevent adipose tissue dysfunction in obesity.
10 Years of GWAS in intraocular pressure
Authors: Gao Xiaoyi Raymond , Chiariglione Marion , Choquet Hélène , Arch Alexander J. 
Published: April 2023

Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma, the leading cause of irreversible blindness worldwide. In this review, we summarize the findings of genome-wide association studies (GWASs) of IOP published in the past 10 years and prior to December 2022. Over 190 genetic loci and candidate genes associated with IOP have been uncovered through GWASs, although most of these studies were conducted in subjects of European and Asian ancestries. We also discuss how these common variants have been used to derive polygenic risk scores for predicting IOP and glaucoma, and to infer causal relationship with other traits and conditions through Mendelian randomization. Additionally, we summarize the findings from a recent large-scale exome-wide association study (ExWAS) that identified rare variants associated with IOP in 40 novel genes, six of which are drug targets for clinical treatment or are being evaluated in clinical trials. Finally, we discuss the need for future genetic studies of IOP to include individuals from understudied populations, including Latinos and Africans, in order to fully characterize the genetic architecture of IOP.