bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amygdalar activity measured using FDG-PET/CT at head and neck cancer staging independently predicts survival
Authors: Hassan Malek Z. O. , Tawakol Ahmed , Wang Ying , Alvi Raza M. , Awadalla Magid , Jones-O’Connor Maeve , B. Bakar Rula , Banerji Dahlia , Rokicki Adam , Zhang Lili , Mulligan Connor P. , Osborne Michael T. , Zarif Azmaeen , Hammad Basma , Chan Annie W. , Wirth Lori J. , Warner Erica T. , Pitman Roger K. , Armstrong Katrina A. , Addison Daniel , Neilan Tomas G. 
Published: August 2023

Importance
The mechanisms underlying the association between chronic stress and higher mortality among individuals with cancer remain incompletely understood.

Objective
To test the hypotheses that among individuals with active head and neck cancer, that higher stress-associated neural activity (ie. metabolic amygdalar activity [AmygA]) at cancer staging associates with survival.

Design
Retrospective cohort study.

Setting
Academic Medical Center (Massachusetts General Hospital, Boston).

Participants
240 patients with head and neck cancer (HNCA) who underwent 18F-FDG-PET/CT imaging as part of initial cancer staging.

Measurements
18F-FDG uptake in the amygdala was determined by placing circular regions of interest in the right and left amygdalae and measuring the mean tracer accumulation (i.e., standardized uptake value [SUV]) in each region of interest. Amygdalar uptake was corrected for background cerebral activity (mean temporal lobe SUV).

Results
Among individuals with HNCA (age 59±13 years; 30% female), 67 died over a median follow-up period of 3 years (IQR: 1.7–5.1). AmygA associated with heightened bone marrow activity, leukocytosis, and C-reactive protein (P<0.05 each). In adjusted and unadjusted analyses, AmygA associated with subsequent mortality (HR [95% CI]: 1.35, [1.07–1.70], P = 0.009); the association persisted in stratified subset analyses restricted to patients with advanced cancer stage (P<0.001). Individuals within the highest tertile of AmygA experienced a 2-fold higher mortality rate compared to others (P = 0.01). The median progression-free survival was 25 months in patients with higher AmygA (upper tertile) as compared with 36.5 months in other individuals (HR for progression or death [95%CI], 1.83 [1.24–2.68], P = 0.001).

Conclusions and relevance
AmygA, quantified on routine 18F-FDG-PET/CT images obtained at cancer staging, independently and robustly predicts mortality and cancer progression among patients with HNCA. Future studies should test whether strategies that attenuate AmygA (or its downstream biological consequences) may improve cancer survival.
A health terminological system for inherited retinal diseases: Content coverage evaluation and a proposed classification
Authors: Sabbaghi Hamideh , Madani Sina , Ahmadieh Hamid , Daftarian Narsis , Suri Fatemeh , Khorrami Farid , Saviz Proshat , Shahriari Mohammad Hasan , Motevasseli Tahmineh , Fekri Sahba , Nourinia Ramin , Moradian Siamak , Sheikhtaheri Abbas 
Published: August 2023

Purpose
To present a classification of inherited retinal diseases (IRDs) and evaluate its content coverage in comparison with common standard terminology systems.

Methods
In this comparative cross-sectional study, a panel of subject matter experts annotated a list of IRDs based on a comprehensive review of the literature. Then, they leveraged clinical terminologies from various reference sets including Unified Medical Language System (UMLS), Online Mendelian Inheritance in Man (OMIM), International Classification of Diseases (ICD-11), Systematized Nomenclature of Medicine (SNOMED-CT) and Orphanet Rare Disease Ontology (ORDO).

Results
Initially, we generated a hierarchical classification of 62 IRD diagnosis concepts in six categories. Subsequently, the classification was extended to 164 IRD diagnoses after adding concepts from various standard terminologies. Finally, 158 concepts were selected to be classified into six categories and genetic subtypes of 412 cases were added to the related concepts. UMLS has the greatest content coverage of 90.51% followed respectively by SNOMED-CT (83.54%), ORDO (81.01%), OMIM (60.76%), and ICD-11 (60.13%). There were 53 IRD concepts (33.54%) that were covered by all five investigated systems. However, 2.53% of the IRD concepts in our classification were not covered by any of the standard terminologies.

Conclusions
This comprehensive classification system was established to organize IRD diseases based on phenotypic and genotypic specifications. It could potentially be used for IRD clinical documentation purposes and could also be considered a preliminary step forward to developing a more robust standard ontology for IRDs or updating available standard terminologies. In comparison, the greatest content coverage of our proposed classification was related to the UMLS Metathesaurus.
Increased frequency and quantity of mucosal and plasma cytomegalovirus replication among Ugandan Adults Living with HIV
Authors: McClymont Elisabeth , Bone Jeffrey , Orem Jackson , Okuku Fred , Kalinaki Mary , Saracino Misty , Huang Meei-Li , Selke Stacy , Wald Anna , Corey Lawrence , Casper Corey , Boucoiran Isabelle , Johnston Christine , Gantt Soren 
Published: August 2023

Background
Co-infection with HIV can result in impaired control of cytomegalovirus (CMV) replication, increasing the likelihood of disease and onward transmission. The objective of this analysis was to measure the impact of HIV on CMV replication in an intensively-sampled cohort in Kampala, Uganda.

Methods
CMV seropositive men and women aged 18–65, with or without HIV co-infection, were followed for one month. Daily oral swabs and weekly anogenital swabs and plasma were collected. Quantitative CMV PCR was performed on all samples.

Results
Eighty-five participants were enrolled and provided ≥1 oral swab; 43 (51%) were HIV-seropositive. People living with HIV (PLWH; median CD4 count 439 cells/mm3; none on antiretrovirals) had 2–4 times greater risk of CMV detection at each anatomical site assessed. At the oral site, 773 of 1272 (61%) of samples from PLWH had CMV detected, compared to 214 of 1349 (16%) among people without HIV. Similarly, the mean CMV quantity was higher among PLWH at all anatomical sites, with the largest difference seen for oral swabs (mean difference 1.63 log/mL; 95% CI 1.13–2.13). Among PLWH, absolute quantity of CD4+ T-cells was not associated with risk of CMV detection. HIV plasma RNA quantity was positively correlated with oral CMV shedding frequency, but not detection at other sites.

Conclusions
Mucosal and systemic CMV replication occurs at higher levels in PLWH than people without HIV, particularly oral shedding, which is a major mode of CMV transmission. Increased CMV replication despite relatively preserved CD4+ T-cell counts suggests that additional interventions are required to improve CMV control in PLWH.
Brownfield land and health: A systematic review of the literature
Authors: Wang Weiyi , Dack Sarah , Mudway Ian , Walder Holly , Davies Bethan , Kamanyire Robie , Fecht Daniela 
Published: August 2023

Background
Brownfield land is vacant or derelict land that was previously used for industrial or commercial purposes. Brownfield land is increasingly being targeted for housing development, however, depending on the previous use and remediation activity, it might pose potential risks to the health of residents on or in the vicinity of redeveloped sites. This systematic review of the literature synthesises the empirical evidence on the associations between brownfield land and health.

Methods
We systematically searched EMBASE, MEDLINE, Global Health, Web of Science, Scopus and GreenFile using a study protocol registered on PROSPERO (CRD42022286826). The search strategy combined the keywords “brownfield” and its interchangeable terms such as “previously developed land”, and any health outcomes such as “respiratory diseases” and “mortality”. Publications identified from the search were screened for eligibility by two authors, and data were extracted from the selected articles. Study quality was assessed based on the Newcastle-Ottawa Scale.

Results
Of the 1,987 records retrieved, 6 studies met the inclusion criteria; 3 ecological studies, 2 cross-sectional studies, and 1 longitudinal study. There was considerable heterogeneity in the exposure metrics and health outcomes assessed. All studies found significant positive associations between brownfield land proximity or density with at least one health relevant outcome, including poorer self-reported general health, increased mortality rates, increased birth defects, increased serum metal levels, and accelerated immune ageing.

Conclusions
Brownfield land may negatively affect the health of nearby residents. The epidemiological evidence on health effects associated with brownfield land in local communities, however, remains inconclusive and limited. Further studies are required to build the evidence base to inform future housing policies and urban planning.
Arthroscopically assisted internal fixation for treatment of acute ankle fracture: A systematic review and meta-analysis of comparative studies
Authors: Zhuang Chen , Guo Wenxuan , Chen Wenhuan , Pan Yu , Zhuang Rujie 
Published: August 2023

Background
Arthroscopically assisted reduction and internal fixation (ARIF) allows for the assessment of joint congruity following anatomic reduction, identification of occult intra-articular lesions, and treatment of traumatic intra-articular pathologies. The aim of this systematic review and meta-analysis was to provide evidence on whether ARIF is an alternative treatment protocol for ankle fractures.

Methods
The PubMed, Embase, and Cochrane Library databases were searched independently by two investigators from the inception dates to October 9, 2022, for comparative studies. The risk-of-bias tool of the Cochrane Collaboration for Randomized Controlled Trials and the methodological index for non-randomized studies (MINORS) were used for assessing the methodological quality. Outcomes were evaluated in terms of the Olerud–Molander Ankle Score (OMAS), American Orthopaedic Foot and Ankle Society (AOFAS) Ankle–Hindfoot Scale, post-operative complications, arthroscopic findings, Visual Analogue Scale (VAS) score, and operation time. Cochrane Review Manager Software 5.4 was used to perform the statistical analysis.

Results
A total of 10 trials involving 755 patients were included in this meta-analysis. The results revealed that ARIF for ankle fractures was superior regarding functional outcomes and VAS scores when compared with open reduction and internal fixation (ORIF). No significant difference was noted in the post-operative complication rate and the operation time between the ARIF and ORIF groups. A high incidence of chondral or osteochondral lesions (OCLs), ligamentous injuries, and loose bodies with ankle fractures was found by ankle arthroscopy.

Conclusions
ARIF for ankle fractures might be beneficial to offer superior functional outcomes and VAS score than ORIF. Orthopedic surgeons should take a high incidence of OCLs and ligamentous injuries into consideration for the treatment of acute ankle fractures. We believe that with the increase in surgical experience, the occurrence of post-operative complications and the extension of operation time will no longer be a potential concern for surgeons.
Total pancreatectomy with islet autotransplantation reduces opioid use and improves nutritional support in children with debilitating pancreatitis
Authors: Heinzman Christie , Hornung Lindsey , Lin Tom K. , Lowe Colleen M. O. , Vitale David S. , Abu-El-Haija Maisam , Nathan Jaimie D. 
Published: August 2023

Background
Chronic pancreatitis (CP) can result in opioid dependence and nutritional challenges in children. Total pancreatectomy with islet autotransplantation (TPIAT) is a viable surgical option in appropriately selected patients. We examined differences between children who met criteria for TPIAT versus those who did not and continued with non-operative management.

Methods
Retrospective observational cohort study of patients evaluated for TPIAT between August 2014 and July 2020 was performed. Cohort-based analyses between TPIAT and non-TPIAT groups were performed.

Results
Analyses included 121 patients, 69 of whom underwent TPIAT. Demographics, genetic risk factors, and anatomic variants did not differ between groups. TPIAT patients were more likely to have CP (88% vs 71%; p = 0.02), had higher median number of endoscopic retrograde cholangiopancreatography procedures (2.0 vs 1.0; p = 0.0001), and had higher likelihood of opioid use (61% vs 42%; p = 0.04) and nutritional supplementation (23% vs 4%; p = 0.004), compared to non-TPIAT. At 6 months post-TPIAT, patients had lower use of any analgesic pain medications (39% vs 73%; p = 0.0002) and lower use of opioids (9% vs 39%; p = 0.0006), compared to non-TPIAT patients at 6 months after evaluation. At 6 months post-TPIAT, rate of exclusively oral nutrition increased from 77% to 86%, and total parenteral nutrition use decreased from 13% to 0% (p = 0.02).

Conclusions
In children referred for TPIAT evaluation, there is greater burden of disease in those selected for operation, compared to patients who do not undergo operation. TPIAT achieves lower analgesic pain medication use compared to continuation with non-TPIAT management and achieves freedom from nutritional supplementation.
Level of evidence: Retrospective comparative study, Level III.
Morphometric characterization and temporal temperature measurements during hepatic microwave ablation in swine
Authors: Varble Nicole A. , Bakhutashvili Ivane , Reed Sheridan L. , Delgado Jose , Tokoutsi Zoi , Frackowiak Bruno , Baragona Marco , Karanian John W. , Wood Bradford J. , Pritchard William F. 
Published: August 2023

Purpose
Heat-induced destruction of cancer cells via microwave ablation (MWA) is emerging as a viable treatment of primary and metastatic liver cancer. Prediction of the impacted zone where cell death occurs, especially in the presence of vasculature, is challenging but may be achieved via biophysical modeling. To advance and characterize thermal MWA for focal cancer treatment, an in vivo method and experimental dataset were created for assessment of biophysical models designed to dynamically predict ablation zone parameters, given the delivery device, power, location, and proximity to vessels.

Materials and methods
MWA zone size, shape, and temperature were characterized and monitored in the absence of perfusion in ex vivo liver and a tissue-mimicking thermochromic phantom (TMTCP) at two power settings. Temperature was monitored over time using implanted thermocouples with their locations defined by CT. TMTCPs were used to identify the location of the ablation zone relative to the probe. In 6 swine, contrast-enhanced CTs were additionally acquired to visualize vasculature and absence of perfusion along with corresponding post-mortem gross pathology.

Results
Bench studies demonstrated average ablation zone sizes of 4.13±1.56cm2 and 8.51±3.92cm2, solidity of 0.96±0.06 and 0.99±0.01, ablations centered 3.75cm and 3.5cm proximal to the probe tip, and temperatures of 50 ºC at 14.5±13.4s and 2.5±2.1s for 40W and 90W ablations, respectively. In vivo imaging showed average volumes of 9.8±4.8cm3 and 33.2±28.4cm3 and 3D solidity of 0.87±0.02 and 0.75±0.15, and gross pathology showed a hemorrhagic halo area of 3.1±1.2cm2 and 9.1±3.0cm2 for 40W and 90W ablations, respectfully. Temperatures reached 50ºC at 19.5±9.2s and 13.0±8.3s for 40W and 90W ablations, respectively.

Conclusion
MWA results are challenging to predict and are more variable than manufacturer-provided and bench predictions due to vascular stasis, heat-induced tissue changes, and probe operating conditions. Accurate prediction of MWA zones and temperature in vivo requires comprehensive thermal validation sets.
Different Models, One Goal: Doing Theatre, Democracy and Social Justice: A Festschrift in Honour of Prof. Tor Joe Iorapuu, Adediran Kayode Ademiju-Bepo, Umaru Hussaini Tsaku, Tijime Justin Awuawuer, Shadrack Teryila Ukuma and Ben Alfred Abugh (eds) (2022)
Authors: Dugga Victor S. , Onwe Mark O. 
Published: August 2023

Review of: Different Models, One Goal: Doing Theatre, Democracy and Social Justice: A Festschrift in Honour of Prof. Tor Joe Iorapuu, Adediran Kayode Ademiju-Bepo, Umaru Hussaini Tsaku, Tijime Justin Awuawuer, Shadrack Teryila Ukuma and Ben Alfred Abugh (eds) (2022)
Jos: DynastyGold Global Impact Communications, 789 pp.,
ISBN 978-978-55547-6-2, h/bk, $21.67
Multidisciplinary Diagnosis and Management of a Rare Dysplastic Adenoma Involving a Pancreas Transplant
Authors: Kayaalp Cemil , Are Vijay S. , Kandaswamy Raja , Amateau Stuart K. 
Published: August 2023

ABSTRACT
A 52-year-old man with a history of type 1 diabetes mellitus with diabetic nephropathy who underwent simultaneous pancreas–kidney transplant over a decade ago presented with small bowel obstruction and was found by enteroscopy to have a carpeted lesion encompassing the small bowel anastomosis in the region of the donor pancreas. As endoscopic mucosal resection was impracticable because of technical limitations, the patient was referred to transplant surgical team for surgical exploration and ultimately required organ resection. This represents a unique presentation of an ampullary adenoma with high-grade dysplasia requiring device-assisted enteroscopy requiring multidisciplinary management.
Timely Endoscopic Recognition of Aortoesophageal Fistula With Successful Treatment
Authors: Brotherton Tim , Numan Laith , Al-Kaade Samer 
Published: August 2023

ABSTRACT
Aortoesophageal fistula (AEF) is a devastating cause of upper gastrointestinal bleeding that occurs because of pathologic communication of the esophagus with the aorta. Bleeding AEF has high mortality even with appropriate interventions. In this study, we present a case of a 52-year-old man who presented with hematemesis, which was found to be due to an actively bleeding AEF. Prompt identification of the fistula led to multiple endoscopic interventions that stabilized the patient and allowed him to undergo emergent endovascular aortic stent placement with successful bleeding control.
The total testing process harmonization: the case study of SARS-CoV-2 serological tests
Authors: Colombini Alessandra , Divieto Carla , Tomaiuolo Rossella , Mortati Leonardo , Petiti Jessica , Di Resta Chiara , Banfi Giuseppe 
Published: August 2023

Abstract
The total testing process harmonization is central to laboratory medicine, leading to the laboratory test’s effectiveness. In this opinion paper the five phases of the TTP are analyzed, describing, and summarizing the critical issues that emerged in each phase of the TTP with the SARS-CoV-2 serological tests that have affected their effectiveness. Testing and screening the population was essential for defining seropositivity and, thus, driving public health policies in the management of the COVID-19 pandemic. However, the many differences in terminology, the unit of measurement, reference ranges and parameters for interpreting results make analytical results difficult to compare, leading to the general confusion that affects or completely precludes the comparability of data. Starting from these considerations related to SARS-CoV-2 serological tests, through interdisciplinary work, the authors have highlighted the most critical points and formulated proposals to make total testing process harmonization effective, positively impacting the diagnostic effectiveness of laboratory tests.
Exploring the antimicrobial potential of biologically synthesized zero valent iron nanoparticles
Authors: Akram Kiran , Khan Ibrar , Rehman Aneela , Hayat Azam , Rehman Mujaddad Ur , Khurshid Mohsin , Hayat Palwasha , Alshammari Abdulrahman , Alharbi Metab , Massa Salvatore 
Published: August 2023

Abstract
The widespread use of antibiotics has resulted in the emergence of multidrug-resistant bacteria. Therefore, it is essential to explore alternative strategies to effectively combat medically significant resistant pathogens. In recent years, nanoparticles (NPs) have emerged as a promising alternative source of antimicrobial agents. While nanoscale particles were traditionally synthesized using chemical techniques, the development of metallic NPs using biological methods has garnered attention. This current study focuses on the synthesis of iron NPs (Fe NPs) using metal-tolerant fungal strains, as numerous microorganisms serve as environmentally safe and durable precursors to produce persistent and bi-functional NPs. The study involved the isolation and evaluation of ten fungal strains that are resistant to heavy metals to determine their ability to produce Fe NPs. The biologically synthesized Fe NPs were characterized using X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), and scanning electron microscopy techniques. The XRD results indicated the presence of Fe in nanopowder form, displaying a series of reflection angles (2θ) at 65° and 75° indicating the existence of cubic planes. EDX analysis revealed the presence of ferrous and ferric elements, along with zero-valent Fe NPs. Micrographs of the surface topology displayed spherical aggregation of the synthesized NPs. Furthermore, the Fe NPs exhibited promising antibacterial potential against selected bacterial strains, including Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Cronobacter sakazakii, Listeria innocua, and Enterococcus fecalis. This study demonstrates that the biological synthesis of metallic NPs is environmentally safe, and Fe NPs produced through mycological means could be utilized to combat antibiotic-resistant pathogenic strains.
The interpretation of [+distal] in demonstratives and complementizers
Authors: Staps Camil , Rooryck Johan 
Published: August 2023

Abstract
This article argues that the [+distal] feature of demonstrative that is also present in complementizer that, and has not bleached away. In particular, we argue that complementizer that is referential: it refers to an element in the Shared Discourse Space (an extension of the Common Ground) that can be seen as distal. This allows us to explain (i) that direct speech patterns with [−distal] (Sue said this/#that: “It is raining”) while indirect speech patterns with [+distal] (Sue said *this/that it is raining); (ii) the use of that in exclamatives (That bio industry is still allowed!); and (iii) that optional that is more frequently used when there is some sort of context between Speaker and Addressee. This last phenomenon has parallels in Romance complementizers derived from Latin quod, which can likewise be seen as [+distal]. We propose that [+distal] is a marker of Addressee involvement, which can account for all these phenomena, and can be extended to demonstrative uses of that. In exophoric contexts, [+distal] additionally marks actual distance. The interpretation of Addressee involvement and actual distance depends on context; we propose that it is derived from the interaction between the syntactic DP/CP domain and the pragmatic exophoric/endophoric distinction.
A Study of the Higher-Order Schwarzian Derivatives of Hirotaka Tamanoi
Authors: Hu Zhenyong , Fan Jinhua , Wang Xiaoyuan , Srivastava H. M. 
Published: August 2023

ABSTRACT
In this paper, we study the higher-order Schwarzian derivative Sn
(f) proposed by H. Tamanoi [Higher Schwarzian operators and combinatorics of the Schwarzian derivative, Math. Ann. 305 (1996), 127–151]. For the strongly starlike functions of order α and strongly convex functions of order α, the sharp bound of |S
3(f)(0)| is obtained. When n ∈ [2, 7], we prove that the higher Bers maps induced by Sn
(f) on Weil-Petersson Teichmüller space and BMO-Teichmüller space are holomorphic.
Besov and Triebel-Lizorkin Capacity in Metric Spaces
Authors: Karak Nijjwal , Mondal Debarati 
Published: August 2023

ABSTRACT
We prove a lower bound estimate for Hajłasz-Besov capacity in metric spaces in terms of Netrusov-Hausdorff content. We also prove a similar estimate for Hajłasz-Triebel-Lizorkin capacity in terms of Hausdoroff content. These results are improvements of the earlier results obtained by Nuutinen in 2016 and the first author in 2020.