bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dementia research in Ireland: What should we prioritise?
Authors: Rogan Carol , Rock Bernadette , Begley Emer , Boland Barry , Brazil Kevin , Diaz-Orueta Unai , Donnelly Sarah , Foley Michael , Foley Tony , Hannigan Caoimhe , Hopper Louise , Keogh Fiona , Lawlor Brian , Leroi Iracema , O'Neill Cora , O'Philbin Laura , Pertl Maria , Trépel Dominic , Kennelly Seán 
Published: February 2023

Background: Dementia research prioritisation allows for the systematic allocation of investment in dementia research by governments, funding agencies and the private sector. There is currently a lack of information available in Ireland regarding priority areas for dementia research. To address this gap, a dementia research prioritisation exercise was undertaken, consisting of an online survey of professionals in the dementia field and workshops for people living with dementia and family carers. Methods: (1) An anonymous online survey of professionals, based on an existing WHO global survey: The global survey was adapted to an Irish context and participants were asked to score 65 thematic research avenues under 5 criteria; (2) A mixed-methods exercise for people living with dementia and family carers: This involved two facilitated workshops where participants voted on the research themes they felt were important to them and should be addressed through research. Results: Eight of the top ten research priorities in the survey of professionals (n=108) were focused on the delivery and quality of care and services for people with dementia and carers. Other research avenues ranked in the top ten focused on themes of timely and accurate diagnosis of dementia in primary health-care practices and diversifying therapeutic approaches in clinical trials. Participants in the workshops (n=13) ranked ‘better drugs and treatment for people with dementia’, ‘dementia prevention/ risk reduction’ and ‘care for people with dementia and carers’ as their top priority areas. Conclusions: Findings from this prioritisation exercise will inform and motivate policymakers, funders, and researchers to support and conduct research to address the burden of dementia and ensure that the limited resources made available are spent on research that has the most impact for those who will benefit from and use the results of research.
From the Boardroom: Making Purpose Research Relevant for Practice
Authors: Durand Rodolphe 
Published: February 2023

This paper reflects on the burgeoning yet fragmented research on corporate purpose. Drawing on three actual situations I experienced, I point to three challenges of purpose research that require our scholarly attention to produce research relevant for practice: purpose justification, implementation, and evaluation.History: This paper has been accepted for the Strategy Science Special Issue on Corporate Purpose.
Rotational play
Authors: Grimmer Tamsin 
Published: February 2023

Our lives are surrounded by circular movement and round objects. Tamsin Grimmer looks at children and babies' fascination with objects that spin or roll and provides practical advice on how to integrate rotational play in your setting. Positioning – children show an interest in where things are, positioning items in lines, rows or by size. They may be fascinated with different types of lines (vertical or horizontal) or walk around sand tray edges or balance on walls. Some children may even prefer certain foods not to touch other foods or may be interested in the position of their bodies by lying on floors or under tables.
Mid- to late-term follow-up of primary hip and knee arthroplasty: the UK SAFE evidence-based recommendations
Authors: Kingsbury Sarah R. , Smith Lindsay K. K. , Pinedo-Villanueva Rafael , Judge Andrew , West Robert , Wright Judy M. , Stone Martin H. , Conaghan Philip G. 
Published: February 2023

AimsTo review the evidence and reach consensus on recommendations for follow-up after total hip and knee arthroplasty.MethodsA programme of work was conducted, including: a systematic review of the clinical and cost-effectiveness literature; analysis of routine national datasets to identify pre-, peri-, and postoperative predictors of mid-to-late term revision; prospective data analyses from 560 patients to understand how patients present for revision surgery; qualitative interviews with NHS managers and orthopaedic surgeons; and health economic modelling. Finally, a consensus meeting considered all the work and agreed the final recommendations and research areas.ResultsThe UK poSt Arthroplasty Follow-up rEcommendations (UK SAFE) recommendations apply to post-primary hip and knee arthroplasty follow-up. The ten-year time point is based on a lack of robust evidence beyond ten years. The term 'complex cases' refers to individual patient and surgical factors that may increase the risk for arthroplasty failure. For Orthopaedic Data Evaluation Panel (ODEP) 10A* minimum implants, it is safe to disinvest in routine follow-up from one to years post-non-complex hip and knee arthroplasty provided there is rapid access to orthopaedic review. For ODEP 10A* minimum implants in complex cases, or non-ODEP 10A* minimum implants, periodic follow-up post-hip and knee arthroplasty may be required from one to ten years. At ten years post-hip and knee arthroplasty, clinical and radiological evaluation is recommended. After ten years post-hip and knee arthroplasty, frequency of further follow-up should be based on the ten-year assessment; ongoing rapid access to orthopaedic review is still required.ConclusionComplex cases, implants not meeting the ODEP 10A* criteria, and follow-up after revision surgery are not covered by this recommendation.Cite this article: Bone Jt Open 2023;4(2):72–78.
sPhaseStation: a whole slide quantitative phase imaging system based on dual-view transport of intensity phase microscopy
Authors: Zhu Lin , Xiao Zhibo , Chen Chao , Sun Aihui , He Xiaoliang , Jiang Zhilong , Kong Yan , Xue Liang , Liu Cheng , Wang Shouyu 
Published: February 2023

Whole slide imaging scans a microscope slide into a high-resolution digital image, and it paves the way from pathology to digital diagnostics. However, most of them rely on bright-field and fluorescence imaging with sample labels. In this work, we designed sPhaseStation, which is a dual-view transport of intensity phase microscopy-based whole slide quantitative phase imaging system for label-free samples. sPhaseStation relies on a compact microscopic system with two imaging recorders that can capture both under and over-focus images. Combined with the field of view (FoV) scan, a series of these defocus images in different FoVs can be captured and stitched into two FoV-extended under and over-focus ones, which are used for phase retrieval via solving the transport of intensity equation. Using a 10× micro-objective, sPhaseStation reaches the spatial resolution of 2.19 µm and obtains the phase with high accuracy. Additionally, it acquires a whole slide image of a 3mm×3mm region in 2 min. The reported sPhaseStation could be a prototype of the whole slide quantitative phase imaging device, which may provide a new perspective for digital pathology.
Monitoring of mitochondrial oxygen tension in the operating theatre: An observational study with the novel COMET® monitor
Authors: Harms Floor A. , Streng Lucia W. J. M. , Wefers Bettink Mark A. , de Wijs Calvin J. , Römers Luuk H. , Janse Rineke , Stolker Robert J. , Mik Egbert G. 
Published: February 2023

Introduction
The newly introduced Cellular Oxygen METabolism (COMET®) monitor enables the measurement of mitochondrial oxygen tension (mitoPO2) using the protoporphyrin IX triplet state lifetime technique (PpIX-TSLT). This study aims to investigate the feasibility and applicability of the COMET® measurements in the operating theatre and study the behavior of the new parameter mitoPO2 during stable operating conditions.

Methods
In this observational study mitochondrial oxygenation was measured in 20 patients during neurosurgical procedures using the COMET® device. Tissue oxygenation and local blood flow were measured by the Oxygen to See (O2C). Primary outcomes included mitoPO2, skin temperature, mean arterial blood pressure, local blood flow and tissue oxygenation.

Results
All patients remained hemodynamically stable during surgery. Mean baseline mitoPO2 was 60 ± 19 mmHg (mean ± SD) and mean mitoPO2 remained between 40–60 mmHg during surgery, but tended to decrease over time in line with increasing skin temperature.

Conclusion
This study presents the feasibility of mitochondrial oxygenation measurements as measured by the COMET® monitor in the operating theatre and shows the parameter mitoPO2 to behave in a stable and predictable way in the absence of notable hemodynamic alterations. The results provide a solid base for further research into the added value of mitochondrial oxygenation measurements in the perioperative trajectory.
Outcomes of vaccinations against respiratory diseases in patients with end-stage renal disease undergoing hemodialysis: A systematic review and meta-analysis
Authors: Puspitasari Metalia , Sattwika Prenali D. , Rahari Dzerlina S. , Wijaya Wynne , Hidayat Auliana R. P. , Kertia Nyoman , Purwanto Bambang , Thobari Jarir At 
Published: February 2023

Due to the nature of the disease, end-stage renal disease (ESRD) patients suffer from dysfunction of the adaptive immune system, which leads to a poorer response to vaccination. Accordingly, it is crucial to evaluate the efficacy and safety of management strategies, including vaccinations, which could potentially reduce the risk of respiratory diseases, such as pneumonia, influenza, or COVID-19, and its associated outcomes. We searched PubMed, CENTRAL, ScienceDirect, Scopus, ProQuest, and Google Scholar databases using designated MeSH keywords. The risk of bias was assessed using ROBINS-I. The quality of evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. Relative risk (RR) and 95% confidence interval (CI) were calculated. Heterogeneity was investigated using forest plots and I2 statistics. This systematic review included a total of 48 studies, with 13 studies of influenza (H1N1 and H3N2) vaccination and 35 studies of COVID-19 vaccination. H1N1 vaccination in ESRD patients undergoing hemodialysis induced lower seroconversion rates (RR 0.62, 95% CI: 0.56–0.68, p <0.00001) and lower seroprotection rates (RR 0.76, 95% CI: 0.70–0.83, p <0.00001) compared to controls. H3N2 vaccination in ESRD patients undergoing hemodialysis yielded lower seroconversion rates (RR 0.76, 95% CI: 0.68–0.85, p <0.00001) and lower seroprotection rates (RR 0.84, 95% CI: 0.77–0.90, p <0.00001) compared to controls. Twenty-nine studies demonstrate significantly lower antibody levels in ESRD patients undergoing hemodialysis compared to the controls following COVID-19 vaccination. This review presents evidence of lower seroconversion and seroprotection rates after vaccination against viral respiratory diseases in patients with ESRD undergoing hemodialysis. Since hemodialysis patients are more susceptible to infection and severe disease progression, a weakened yet substantial serological response can be considered adequate to recommend vaccination against respiratory diseases in this population. Vaccination dose, schedule, or strategy adjustments should be considered in stable ESRD patients on maintenance hemodialysis.
Trial registration: Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021255983, identifier: CRD42021255983.
Asynchronous digital health interventions for reviewing asthma: A mixed-methods systematic review protocol
Authors: Uzzaman Md. Nazim , Hammersley Vicky , McClatchey Kirstie , Sheringham Jessica , Habib G. M. Monsur , Pinnock Hilary 
Published: February 2023

Introduction
People living with asthma require regular reviews to address their concerns and questions, assess control, review medication, and support self-management. However, practical barriers to attending face-to-face consultations might limit routine reviews. Reviewing asthma using asynchronous digital health interventions could be convenient for patients and an efficient way of maintaining communication between patients and healthcare professionals and improving health outcomes. We, therefore, aim to conduct a mixed-methods systematic review to assess the effectiveness of reviewing asthma by asynchronous digital health interventions and explore the views of patients and healthcare professionals about the role of such interventions in delivering asthma care.

Methods
We will search MEDLINE, Embase, Scopus, PsycInfo, CINAHL, and Cochrane Library from 2001 to present without imposing any language restrictions. We are interested in studies of asynchronous digital health interventions used either as a single intervention or contributing to mixed modes of review. Two review authors will independently screen titles and abstracts, and retrieve potentially relevant studies for full assessment against the eligibility criteria and extract data. Disagreements will be resolved by discussion with the review team. We will use ‘Downs and Black’ checklist, ‘Critical Appraisal Skills Programme’, and ‘Mixed Methods Appraisal Tool’ to assess methodological quality of quantitative, qualitative, and mixed-methods studies respectively. After synthesising quantitative (narrative synthesis) and qualitative (thematic synthesis) data separately, we will integrate them following methods outlined in the Cochrane Handbook for Systematic Reviews of Interventions.

Conclusion
The findings of this review will provide insights into the role of asynchronous digital health interventions in the routine care of people living with asthma.

Trial registration
Systematic review registration: PROSPERO registration number: CRD42022344224.
Inter-departmental variation in surgical treatment of proximal femoral fractures: A nationwide observational cohort study
Authors: Hernefalk Björn , Rydberg Emilia Möller , Ekelund Jan , Rogmark Cecilia , Möller Michael , Hailer Nils P. , Mukka Sebastian , Wolf Olof 
Published: February 2023

Background and purpose
Hip fractures should be treated based on the best available evidence and cost-effectively to optimize the outcome for this large group of frail patients. This study examined nationwide variation in surgical methods used for hip fractures.

Methods
In this cohort study 46,243 patients ≥65 years with a trochanteric hip fracture (THF) or a femoral neck fracture (FNF) registered in the Swedish Fracture Register (SFR) between 1 January 2016 and 31 December 2020 were included. Fractures were classified according to the AO Foundation/Orthopaedic Trauma Association (AO/OTA) fracture classification system. The choice of surgical methods was assessed for each fracture type to compare national variation.

Results
21,312 THFs and 24,072 FNFs (67% women) with a mean age of 83 years (SD 8) were surgically treated. In the treatment of two-fragment THFs (AO/OTA A1) departments ranged from using 90% short intramedullary nails to 98% sliding hip screws. Treating displaced FNFs (AO/OTA B3), the proportion of hemiarthroplasty ranged from 9 to 90%, and internal fixation between 0.6 to 21%, depending on the department.

Interpretation
A mature national fracture register permits the monitoring of treatment provided and thus serves as an important aid in assessing compliance with guidelines. The large inter-departmental variation in the surgical management of hip fractures in Sweden appears unwarranted based on the current evidence, indicating a need for updated national guidelines. Further research will have to clarify the impact of this variation on mortality and re-operation rates.
Colonic Epstein-Barr Virus-Associated Mucocutaneous Ulcer Associated With Ulcerative Colitis
Authors: Chan Patrick P.Y. , Farzin Mahtab , Acharya Priya , Viiala Nicholas , Gilmore Andrew , Crane Harry , Henderson Christopher , Ng Watson , Williams Astrid , Connor Susan J. 
Published: February 2023

ABSTRACT
Epstein-Barr virus-associated mucocutaneous ulcer is a rare lymphoproliferative disorder that occurs in immunosuppressed states that can develop in the gastrointestinal tract and mimic inflammatory bowel disease or other malignancies. We present the case of a 61-year-old man who presented with concurrent acute severe ulcerative colitis and colonic Epstein-Barr virus-associated mucocutaneous ulcer requiring rituximab therapy and a subtotal colectomy.
Medically Refractory Lymphocytic Colitis Successfully Treated With Upadacitinib
Authors: Miyatani Yusuke , Choi David , Du Xiaotang , Hart John , Rubin David T. 
Published: February 2023

ABSTRACT
Lymphocytic colitis is a microscopic colitis characterized endoscopically by nearly normal-appearing colonic mucosa and histology demonstrating intraepithelial lymphocytosis. Microscopic colitis that is refractory to conventional therapies, including budesonide, is rare but challenging and with scarce evidence. Upadacitinib is a novel Janus kinase 1 selective inhibitor approved by the US Food and Drug Administration for atopic dermatitis, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and moderately to severely active ulcerative colitis. We present the first case of lymphocytic colitis refractory to conventional and immunosuppressive therapies, which responded promptly to upadacitinib.
Levocarnitine regulates the growth of angiotensin II-induced myocardial fibrosis cells via TIMP-1
Authors: Shu Jin , Shi Jue , Gu Yiwen , Deng Lei , Zhao Chen , Wu Chun , Zhao Jiachen , Wang Haiya , Jin Li 
Published: February 2023

Abstract
This study aimed to explore the effects of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) on levocarnitine (LC)-mediated regulation of angiotensin II (AngII)-induced myocardial fibrosis (MF) and its underlying mechanisms. H9C2 cells were treated with AngII for 24 h to induce fibrosis. The cells were then treated with LC or transfected with TIMP‐1-OE plasmid/si‑TIMP‐1. Cell apoptosis, viability, migration, and related gene expression were analyzed. AngII treatment significantly upregulated Axl, α-SMA, and MMP3 expression (P < 0.05) and downregulated STAT4 and TIMP1 expression (P < 0.05) relative to the control levels. After transfection, cells with TIMP-1 overexpression/knockdown were successfully established. Compared with that of the control, AngII significantly inhibited cell viability and cell migration while promoting cell apoptosis (P < 0.05). LC and TIMP-1-OE transfection further suppressed cell viability and migration induced by Ang II and upregulated apoptosis, whereas si-TIMP-1 had the opposite effect. Furthermore, LC and TIMP-1-OE transfection downregulated Axl, AT1R, α-SMA, collagen III, Bcl-2, and MMP3 expression caused by AngII and upregulated caspase 3, p53, and STAT4 expression, whereas si-TIMP-1 had the opposite effect. TIMP-1 is therefore a potential therapeutic target for delaying MF progression.
Pharmacological inhibition of the ubiquitin-specific protease 8 effectively suppresses glioblastoma cell growth
Authors: Long Yu , Hu Zengchun , Yang Dian , Wang Fuqiang , Zhao Chen’ge , Zhang Yang , Zhang Yingqiu , Ma Hui , Lv Huiyi 
Published: February 2023

Abstract
Glioblastoma (GBM) is a malignant brain tumor. The purpose of this study is to estimate the potential effects and underlying mechanisms of a ubiquitin-specific protease 8 (USP8) small-molecule inhibitor on the phenotypic characteristics of GBM cells. The growth, migration, invasion, and stemness of GBM LN229 and T98G cells were evaluated by conducting cell proliferation, colony formation, wound healing, transwell, Ki-67 staining, spheroid formation, and ionizing radiation assays, and the results collectively showed the suppressive effects of USP8 inhibition on GBM cells. Furthermore, transcriptomic profiling of GBM cells treated with the USP8 inhibitor deubiquitinase (DUB)-IN-1 revealed significantly altered mRNA expression induced by pharmacological USP8 inhibition, from which we confirmed downregulated Aurora kinase A (AURKA) protein levels using immunoblotting assays. Our findings indicated that the proliferation, invasion, and stemness of LN229 and T98G cells were markedly suppressed by USP8 inhibition. Pharmacological USP8 suppression elicits multiple tumor-inhibitory effects, likely through dysregulating various mRNA expression events, including that of the key cell cycle regulator and oncogenic protein AURKA. Therefore, our observations corroborate the GBM-supportive roles of USP8 and suggest pharmacological USP8 inhibition is a viable therapeutic approach to target GBM. The purpose of this study was to investigate the effect and mechanism of action of the USP8 inhibitor DUB-IN-1 on GBM.
The properties of potato gluten-free doughs: comparative and combined effects of propylene glycol alginate and hydroxypropyl methyl cellulose or flaxseed gum
Authors: Chen Xueting , Gao Jingyan , Cao Geng , Guo Shule , Lu Dingning , Hu Bingbing , Yang Zuoqian , Tong Yi , Wen Chengrong 
Published: February 2023

Abstract
Different methods are often used to make gluten-free (GF) bread to get better bread characteristics. To explore the effects of emulsifiers and hydrocolloids on the characteristics of GF dough, different esterification levels of propylene glycol alginate (PGA), hydroxypropyl methyl cellulose (HPMC), flaxseed gum with (FG) different molecular weight, and the binary blends of HPMC/PGA and FG/PGA were added to GF dough, made with potato starch and potato protein in a ratio of 6:4. The results showed that the potato GF dough with FG and FG/PGA obtained a higher viscoelasticity than the other doughs. HPMC and FG promoted to the formation of network structure, but the network structure formed by PGA and their combination was more developed. It was found that all PGA, HPMC, FG and their combination could improve the softness of GF breads. The results provided a basis for optimizing the quality of potato GF bread.
Achieving a more diverse special education teacher workforce: guiding questions for researchers and policymakers
Authors: Cormier Christopher J. , Scott LaRon A. , Cornelius Kyena E. , Rosenberg Michael S. 
Published: February 2023

Abstract
Attracting, supporting, and retaining special education teachers of color (SETOCs) is critical in shaping a diverse special education teacher workforce in the United States. However, efforts to diversify this workforce are fraught with challenges at the federal, state, and local levels. This paper reviews what is currently known about efforts to attract, support, and retain SETOCs, and provides guidance for policy makers and researchers regarding what still needs to be done to realize a more diverse special education teacher workforce in the US. Four critical domains serve as the foundation for our guiding considerations: funding priorities, strategies to attract SETOCs, the role of educator preparation programs, and strategies to retain SETOCs.