bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermuscular coherence in spinocerebellar ataxias 3 and 6: a preliminary study
Authors: Issa Naoum P. , Aydin Serdar , Bhatnagar Shail , Baumgartner Nicholas W. , Hill Jacquelyn , Aluri Sravya , Valentic Chloe S. , Gomez Christopher M. , Rezania Kourosh 
Published: April 2023

Abstract
Objective: Spinocerebellar ataxias (SCAs) are familial neurodegenerative diseases involving the cerebellum and spinocerebellar tracts. While there is variable involvement of corticospinal tracts (CST), dorsal root ganglia, and motor neurons in SCA3, SCA6 is characterized by a pure, late-onset ataxia. Abnormal intermuscular coherence in the beta-gamma frequency range (IMCbg) implies lack of integrity of CST or the afferent input from the acting muscles. We test the hypothesis that IMCbg has the potential to be a biomarker of disease activity in SCA3 but not SCA6.
Methods:Intermuscular coherence between biceps and brachioradialis muscles was measured from surface EMG waveforms in SCA3 (N=16) and SCA6 (N=20) patients, and in neurotypical subjects (N=23).
Results: IMC peak frequencies were present in the b range in SCA patients and in the g range in neurotypical subjects. The difference between IMC amplitudes in the g and b ranges was significant when comparing neurotypical control subjects to SCA3 (p < 0.01) and SCA6 (p = 0.01) patients. IMCbg amplitude was smaller in SCA3 patients compared to neurotypical subjects (p<0.05), but not different between SCA3 and SCA6 patients or between SCA6 and neurotypical subjects.
Conclusion/significance:IMC metrics can differentiate SCA patients from normal controls.
High incidence and risk factors associated with contrast-induced nephropathy among adults undergoing coronary intervention in a tertiary hospital in Dodoma, Tanzania
Authors: Komanya Francisca B. , Meremo Alfred , Meda John R. 
Published: April 2023

Abstract

Introduction:
Contrast-induced nephropathy (CIN) is the third most prevalent cause of hospital-acquired acute kidney injury. CIN may result in complications that might require renal replacement therapy thus early identification of patients at risk of CIN for better primary prevention is necessary.
Methods:
In this cross-sectional study, we included all patients in whom coronary intervention procedures were done from August 2021 to April 2022 at Benjamin Mkapa cardiac catheterization unit in Dodoma, Tanzania. Patients’ data were collected at baseline and patients were reviewed and laboratory investigations were done within 48 hours post-coronary interventions. Data analysis was done by the SPSS version 25 statistical program, descriptive statistics were used to summarize data; continuous data were reported as Mean (SD) or Median (IQR), and categorical data were summarized using proportions and frequencies. Univariate and multivariate logistic regression analyses were used to identify risk factors associated with the development of contrast-induced nephropathy
Results:
A total of 187 patients were recruited for the study, the incidence of contrast-induced nephropathy was 100 (53.5%) patients. Among those with CIN, the median age was 61 years, 50.3% were female, 78.1% were married, 66.8% lived in urban, 84.5%were non-smokers, and 57.2% were not taking any alcohol. Patients with CIN had baseline median serum creatinine of 101.69 µmol/L, a hemoglobin level of 13.3 g/dl, random blood glucose of 5.55 mmol/l, systolic blood pressure of 145 mmHg and diastolic blood pressure of 86 mmHg. For patients with CIN the prevalence of hypertension was 97(97%) patients, CKD was found in 38 (38%) patients, heart failure was present in 39(39%) patients and diabetes mellitus was present in 29 (29%) patients. Variables with higher odds for CIN were; advanced age ≥ 70 years [OR 2.7 (95% CI: 1.12–6.52) P = 0.027], hypertension [OR 7.9(95% CI: 1.99–31.08) P = 0.003] and diabetes mellitus [ OR 3.3(95% CI: 1.39–7.84) P = 0.007].
Conclusion:
The incidence of contrast-induced nephropathy after coronary interventions in our settings is high as compared to literature reports. Patients aged 70 years and above, those with hypertension and those with diabetes mellitus were at increased risk for CIN.
Buffering Against Exposure to Mental Health Misinformation in Online Communities: The Interplay of Depression Literacy and Expert Moderation
Authors: Bizzotto Nicole , de Bruijn Gert-Jan , Schulz Peter Johannes 
Published: April 2023

Abstract
Background
The proliferation of health misinformation on social media is a growing public health concern. Online communities for mental health (OCMHs) are also considered an outlet for exposure to misinformation. This study explored the impact of the self-reported volume of exposure to mental health misinformation in misinformation agreement and the moderating effects of Depression literacy and Type of OCMHs participation (expert vs. peer-led).
Methods
Participants (n = 403) were recruited in Italian-speaking OCMHs on Facebook. We conducted regression analyses using PROCESS macro (moderated moderation, Model 3). Measures included: the Depression Literacy Questionnaire (Griffiths et al., 2004), the Self-reported Misinformation Exposure in the OCMHs (3 items), and Misinformation Agreement with the exposure items (3 items). Whether participants were members of expert or peer-led OCMHs was also investigated.
Results
The final model explained the 12% variance in the Agreement. There was a positive and significant relationship between Misinformation Exposure and Misinformation Agreement (β = .3221, p < 0.001), a significant two-way interaction between Misinformation Exposure and Depression Literacy (β = -.2179, p < 0.01), and between Self-reported Misinformation Exposure and type of OCMH (β = -.2322, p < 0.05), such that at higher levels of Depression Literacy and in case of participation to in expert-led OCMHs, the relationship Misinformation Exposure-Misinformation Agreement was weaker. Finally, a three-way interaction was found (β =.2497, p < 0.05) that showed that Depression Literacy moderated the positive relationship between Misinformation Exposure and Misinformation Agreement such that the more misinformation participants were exposed to, the more they agreed with it unless they had higher levels of Depression Literacy; this, however, occurred only if they participated in peer-led groups.
Conclusions
Results provide evidence that the more members reported being exposed to mental health misinformation, the more they tended to agree with it, however this was only visible when participants had lower depression literacy and were participating in peer-led OMCH.
Results of this study suggest that both internal factors (i.e., high depression literacy) and external factors (the type of online community individuals were participating to) can buffer about the negative effects of misinformation exposure. It also suggests that increasing depression literacy and expert community moderation could curb the negative consequences of misinformation exposure related to mental health. Results will guide interventions to mitigate the effects of misinformation in OCMHs, including encouraging health professionals in their administration and implementing health education programs.
Proteomics and machine learning identify a distinct biomarker panel to detect prodromal and early Parkinson’s disease
Authors: Hällqvist Jenny , Bartl Michael , Dakna Mohammed , Schade Sebastian , Garagnani Paolo , Bacalini Maria-Giulia , Pirazzini Chiara , Bhatia Kailash , Schreglmann Sebastian R. , Xylaki Mary , Weber Sandrina , Ernst Marielle , Muntean Maria-Lucia , Sixel-Döring Friederike , Franceschi Claudio , Doykov Ivan , Trenkwalder Claudia , Heywood Wendy E. , Consortium PROPAGE-AGEING , Mills Kevin , Mollenhauer Brit 
Published: April 2023

Abstract

Parkinson’s disease (PD) is an increasingly prevalent neurodegenerative disease for which readily available and non-invasive diagnostic biomarkers are scarce. Here, we present a panel of proteomic plasma biomarkers, capable of discriminating between PD and healthy controls with 100% accuracy in a machine learning model. We performed a discovery proteomics study on newly diagnosed PD patients and controls, followed by a multiplexed targeted proteomic assay applied to 99 de novo PD patients and 36 controls. The machine learning model correctly classified all patients, and multiple markers correlated with motor, non-motor symptom severity and cognitive decline. We also evaluated 18 prodromal subjects with iRBD and predicted 72 - 94% of the iRBD samples as PD. This figure matches the clinical conversion rate observed in PD, identifying a pattern already evident in iRBD and indicating pre-symptomatic molecular events. These findings may advance our understanding and supporting of future clinical trials.
Interactive Voice System for Political Education Innovation based on the Era of 5G Converged Media
Authors: Yan Liyan , Zhao Renhui 
Published: April 2023

Abstract
As an emerging technology in the new era, voice interaction technology has always been extremely popular. The development of science and technology in the new era has pushed the research process of various technical points of voice interaction technology to a new era. Intelligent chat is a technology of a new era born in such a trend of the times. With the influence of intelligence in life, it is constantly strengthened, making it a human-computer dialogue intelligent system that can communicate freely like people. In this article, 5G integrated media technology is used to optimize the interactive voice system. This article first introduces the research background of the voice interactive system and analyzes the structure of 5G in detail. At the same time, from the perspective of networks and wireless networks, it explained the potential development potential of 5G, including large-scale channel models, full-scale, and channel coding, and showed its own ideas in terms of advantages and disadvantages and future research directions. In addition, this article also applies 5G integrated media technology to the innovative research of ideological and political education. This research uses 5G integrated media technology as a guide to deeply analyze the generation, development, characteristics and functions of new media, and the characteristics of new media. And its influence on students' moral education, and take Weibo as an example. This article discusses the current status of the application of new media in ideological and political education in contemporary colleges and universities, and the influence of new media on ideological and political education in modern colleges and universities. 5G media technology provides a new idea of ​​an interactive voting system, and provides new ideas for the development of ideological and political education in colleges and universities.
Synthesis of dandelion-like bimetallic nickel-cobalt metal-organic framework as an efficient cathode for high-performance asymmetric supercapacitors
Authors: Yang Chii-Rong , Li Yu-Chiao , Lin Jeng-Yu , Huang Mao-Jung 
Published: April 2023

Abstract
In this current work, pyromellitic acid (PMA) was employed to synthesize a NiCo metal-organic framework (MOF) for supercapacitors. The resultant NiCo-MOF (PMA) showed dandelion-like structure and therefore its surface area was reached as high as 500.7 m2 g− 1. The NiCo-MOF (PMA) delivered an impressive specific capacitance value of 918.8 F g− 1 at the current density of 1 A g− 1. Upon increasing the current density to 10 A g− 1, it retained 61.1% of the capacitance obtained at 1 A g− 1. Moreover, the capacitance retention of 64.3% was achieved even after being charged/discharged at 10 A g− 1 for 10,000 cycles. More importantly, the asymmetric supercapacitor (ASC) based on the NiCo-MOF (PMA) cathode showed specific capacitance of 83.47 F g− 1 at 0.5 A g− 1 and 80.34% of its initial capacitance was still maintained after 5,000 cycles at 5 A g− 1. Furthermore, the ASC delivered an energy density of 23.88 Wh kg− 1 at a power density of 750 Wkg− 1. Additionally, two ASCs in series successfully drove 120 green LEDs lighting for 21 minutes, demonstrating its potential practical applications.
Simulation of the Training Path of Film Creation Talents Based on Artificial Neural Network
Authors: Ma Yanli 
Published: April 2023

Abstract
In today's changing social background, film creative talents cultivated through higher education are difficult to fully adapt to the environment. This paper tries to break the bottleneck of film creation talents by introducing artificial neural network technology, and is committed to cultivating innovative talents. By using artificial neural network technology, the optimal model can be obtained based on target training samples. The main unit of this network technology is neuron. Through the design experiment, we can know that if we want to obtain the best convolutional network reconstruction model, the probability p value must be set to 0.1. Under this environment, the accuracy and convergence speed of the model will be greatly improved, so as to effectively analyze the research on creative talent training path. Then, this paper analyzes the feasibility and necessity of film creation talent training by establishing a talent development prediction function. Through the innovation ability test of the target group and the comprehensive description of the function realization, the following characteristics are obtained: the target student group lacks innovation awareness, but has strong skills and rich imagination. Although the innovation personality is outstanding, the overall innovation ability is still low. Therefore, it is necessary to improve the innovation level of the target student group. Based on this, this paper puts forward several suggestions for talent cultivation. This paper designs several training paths by introducing artificial neural network into the training process of film creation talents.
Verification of the existence of copper-based antifouling paint particles in the sea and their implications for marine microplastic degradation
Authors: NAKATANI Hisayuki , YAMASHIRO Kaito , UCHIYAMA Taishi , MOTOKUCHO Suguru , DAO Anh Thi Ngoc , KIM Hee-Jin , YAGI Mitsuharu , KYOZUKA Yusaku 
Published: April 2023

Abstract
Marine microplastics (MP) and microdebris were retrieved from the five sampling stations between Nagasaki port and Goto Island and were classified into six types. Three of these types, MP (A), Si-based (B), and Cu-based (C) paint particles, were predominant. Type C had no depth dependence, regardless of the presence of cuprous oxide with high specific gravity. The dominant size of type C was less than 10 μm and contained 30 to 50 mol% of Cu content. The long stay behavior of type C suggested that it had implications for degrading type A. To clarify this, polypropylene (PP) film samples containing cuprous oxide were prepared, and their accelerated degradation behavior in seawater was investigated using the advanced oxidation process method using the sulfuric acid radical initiator in seawater of different salinity concentrations. Infrared spectroscopy revealed the formation of a copper soap compound in seawater. Scanning electron microscopy/energy-dispersive X-ray spectroscopy analysis indicated that the chemical reactions between Cl− and cuprous oxide produced Cu+ ions. Changes in the number of polymer chain scissions were investigated at various salinity concentrations of seawater. These findings confirm that Cu+ species promote PP autoxidation.
Developmental Impairment in Children Exposed to Sars-Cov-2 in Utero: A Brazilian Cohort Study.
Authors: Santos Carolina Araujo Damasio , Paula Artemis , Filho Gentil Fonseca , Alves Manoella , Nery Andréia , Pontes Monise , Macedo Erianna , Oliveira Ruy , Freitas Sabrinna , Lima Sarah , Varela Fernanda , Viana Andrezza , Silva Aline , Silva Érika , D’Souza-Li Lília 
Published: April 2023

Abstract

Background The effects of in-utero exposure to maternal SARS-CoV-2 infection on the offspring's neurodevelopment are still unknown.Methods We performed a prospective cohort of babies exposed to SARS-Cov-2 during pregnancy, and a control group of unexposed babies in a low-income area in Northeastern Brazil. All data were prospectively collected from medical records. Children’s neurodevelopment was assessed using the guide for Monitoring Child Development in the IMCI context and the Ages & Stages Questionnaire (ASQ-3), at ages 4, 6, and 12 months. Maternal depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS).Results We followed 127 children for one year, 69 children in the COVID-19 exposed Group (EG), and 68 in the control group (CG). All mothers were unvaccinated at the time included in the cohort. Maternal demographics were similar in the two groups, but prematurity was more prevalent in mothers infected with COVID-19 (21.7% vs. 8.8%, p = .036) and EPDS scores were also significantly higher among the EG (M = 11.00, SD = 6.00 vs. M = 8.68, SD = 4.72, p = 0.04). Both groups had similar rates of cesarean delivery, Apgar scores, average birth weight, head circumference and length at birth. 20.3% of EG children and 5.9% of the CG received a diagnosis of neurodevelopmental delay within 12 months of life (p = 0.013, RR = 3.44; 95% CI, 1.19–9.95). 10% of EG children presented abnormalities at the cranial ultrasound.Conclusions COVID-19 exposure was associated with neurodevelopmental impairment. This study highlights the importance of specific guidelines in the follow-up of children exposed to in-utero SARS-CoV-2 in order to mitigate or prevent long-term effects on children’s health.
Developing a Dual VEGF/PDL1 Inhibitor Based on High-Affinity scFv Heterodimers as an Anti- cancer Therapeutic Strategy
Authors: Tzuri Noam , Yegodayev Ksenia M , Elkabets Moshe , Aharoni Amir , Papo Niv 
Published: April 2023

Abstract
Cancer progression is enhanced by the interaction of programmed death-ligand 1 (PDL1), which is associated with inhibition of the immune response against tumors, and vascular endothelial growth factor (VEGF), which inhibits immune cell activity while inducing angiogenesis and proliferation of cancer cells. Dual inhibition of PDL1 and VEGF may therefore confer a synergistic anti-cancer therapeutic effect. We present a novel strategy for developing a therapeutic that simultaneously binds and inhibits both PDL1 and VEGF. We generated a bi-specific protein, designated DuRan-Bis, comprising a single chain variable fragment (scFv)-based inhibitor of PDL1 fused to an scFv-based inhibitor of VEGF, with the latter being attached to an Fc fragment. We found that DuRan-Bis binds to both PDL1 and VEGF with high affinity. Compared to treatments with mono-specific proteins, alone or in combination, the DuRan-Bis chimera showed superior inhibition of the proliferation of glioblastoma cells. In comparison to treatment with immune cells alone, a combination of immune cells with DuRan-Bis decreased the viability of head and neck cancer cells. To the best of our knowledge, this study is the first to use a single polypeptide chain scFv-scFv-Fc scaffold for engineering a high-affinity bi-specific inhibitor of PDL1 and VEGF.
Association between the MTNR1B, HHEX, SLC30A8, and TCF7L2 single nucleotide polymorphisms and cardiometabolic risk profile in a mixed ancestry South African population
Authors: Ngwa Ndonwi Elvis , Matshazi Don Makwakiwe , Davison Glenda Mary , Kengne Andre Pascal , Matsha Tandi Edith 
Published: April 2023

Abstract
Single nucleotide polymorphisms of the TCF7L2, HHEX, SLC30A8, MTNR1B, SLC2A2 and GLIS3 genes are well established candidate genes for cardiometabolic diseases (CMDs) across different ethnic populations. We investigated their association with CMDs in a mixed ancestry population of South Africa. rs10830963, rs1111875, rs11920090, rs13266634, rs7034200 and rs7903146 SNPs were genotyped by quantitative real time PCR in 1650 participants and Hardy-Weinberg equilibrium (HWE) analyses performed on the SNPs. Diabetes, obesity, hypertension and cardiometabolic traits were compared across genotypes of SNPs in HWE. Linear and logistic regressions adjusting for age, gender and body mass index were used to determine the risk of T2D, obesity and hypertension. rs7903146 (p = 0.055), rs1111875 (p = 0.465), rs13266634 (p = 0.828), and rs10830963 (p = 0.158) were in HWE. The rs10830963 recessive genotype was able to predict FPG, insulin and HOMA-IR, while the rs1111875 recessive genotype was able to predict total cholesterol, triglyceride, LDL cholesterol and FPG. The rs7903146 recessive genotype was able to predict SBP and LDL cholesterol. The recessive genotypes of MTNRIB and HHEX SNPs were associated with T2D traits in the study population and could partially explain the high prevalence of T2D. Further studies are required to confirm these findings and establish candidate genes in the African population.
Intraoperative challenges and complications of cataract surgery between cataract surgery alone and phacovitrectomy in eyes with diabetic retinopathy
Authors: Hwang Sung Ha , Kim Haram , Lee Dae Yeong , Nam Dong Heun 
Published: April 2023

Abstract
Background To compare the intraoperative challenges, complications, and operation time of illuminated chopper-assisted cataract surgery between cataract surgery only and phacovitrectomy in eyes with diabetic retinopathy.Methods One university hospital, retrospective case series. Two hundred ninety-five eyes of 295 consecutive patients with diabetic retinopathy who underwent cataract surgery only or phacovitrectomy were retrospectively reviewed. Intraoperative challenges and complications of cataract surgery were thoroughly analyzed by 3D viewing of digitally recorded videos. The pupil diameter, operation time, and improved efficacy (100/operation time × pupil diameter) were compared between the cataract surgery only and phacovitrectomy groups. Mann-Whitney U test, Pearson’s chi-square or Fisher’s exact tests were performed for statistical analysis.Results Of the 295 eyes, 211 underwent cataract surgery only, and 84 underwent phacovitrectomy. Intraoperative challenges such as small pupil, miosis, or poor red reflex occurred more frequently (46 [21.8%] vs. 28 [33.3%], p = 0.029); pupil diameter was smaller (7.34 ± 0.94 vs. 6.89 ± 0.88 mm, p < 0.001) in the phacovitrectomy group than in the cataract surgery only group; however, rates of posterior capsule rupture and operation time were not different between the two groups (0 [0%] vs. 1 [1.2%], p = 0.285; 16.54 ± 2.65 vs. 16.31 ± 4.30 min, p = 0.434). Improved efficacy was higher in the phacovitrectomy group (0.85 ± 0.18 vs. 0.97 ± 0.28, p = 0.002).Conclusions The use of an illuminated chopper is a potential solution for diabetic cataract surgery, particularly in phacovitrectomy, by decreasing the use of supplemental devices, operation time, and posterior capsule rupture.Trial registration: retrospectively registered.