bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycemic control and cardiovascular complications of type 2 diabetes mellitus
Authors: Druk I. V. , Safronova S. S. 
Published: August 2023

Over the past few decades, the prevalence of diabetes in developed and developing countries has increased dramatically, making diabetes a key health priority worldwide. It can be assumed that an increase in the life expectancy of patients with diabetes significantly affects the prevalence of diabetes, maintaining the trend of its increase. Patients with type 2 diabetes mellitus (DM2) are at higher risk for cardiovascular disease and its adverse outcomes compared to the general population. The pathophysiological relationship between hyperglycemia and cardiovascular disease is beyond doubt. Glycemic control per se remains essential for the successful management of diabetes, prevention of chronic complications of the disease and death. Diabetes control involves, first of all, the achievement of target indicators of carbohydrate metabolism. The use of glycated hemoglobin (HbA1c), despite known sensitivity limitations, has become the standard for assessing glycemic control in diabetic patients. Early achievement of the target HbA1c level reduces the risk of diabetic complications, increases the likelihood of long-term sustainable disease control. Numerous clinical studies have demonstrated that higher HbA1c and greater HbA1c variability are manageable risk factors for adverse cardiovascular events. Optimal hypoglycemic therapy for diabetes in order to reduce cardiovascular risks should ensure the achievement of the target level of glycemic control as soon as possible (the first 3 months of therapy), maintaining the target level of glycemia with the lowest possible HbA1c variability in subsequent years and therapy should be safe. Timely intensification of therapy, including the use of insulin, can prevent the negative consequences of prolonged hyperglycemia. Glar-100 has a high efficacy and safety in comparison with other insulin preparations at the initiation and intensification of DM2 therapy. RingGlar® and Lantus® are equivalent drugs.
The effect of mineral water on the course of experimental oxalate nephrolithiasis
Authors: Lobanov Yu. F. , Zharikov A. Yu. , Zverev Ya. F. , Strozenko L. A. , Kalnitsky A. S. , Micheeva N. M. 
Published: August 2023

Introduction. The number of patients with urolithiasis (UCD) is increasing annually both among the adult population and among children, and therefore it is necessary to develop an integrated approach to the prevention and treatment of this pathology. Most often, with urolithiasis, oxalate-calcium crystalluria is determined, to reduce the level of which, low-mineralized mineral waters with a minimum sodium content are recommended.Aim. To study the effect of mineral water “Serebryanyy klyuch” on the course of experimental calcium oxalate nephrolithiasis.Materials and methods. During the study on laboratory rats, oxalate nephrolithiasis was simulated for 3 weeks by providing a 1% solution of ethylene glycol as a drink, while the rats of the experimental group used mineral water “Serebryanyy klyuch” as a solvent. The results of urine biochemistry (calcium, creatinine, activity of lactate dehydrogenase and γ-glutamyl transferase) and morphological studies (determination of the amount and size of calcium deposits in the kidneys, assessment of the structural and functional state of the nephrothelium) were evaluated.Results. Calcium-oxalate deposits in the control group of rats were detected in 25% of cases, while large-sized stones were observed in the kidney tubules. In the experimental group, the presence of stone deposits was detected in 1 (11.1%) case, with a clear shift towards smaller deposits. Morphological signs indicating the development of dystrophic changes with the phenomena of nephrosclerosis were much less pronounced in the conditions of consumption of mineral water “Serebryanyy klyuch”.Conclusion. Thus, the use of mineral water “Serebryanyy klyuch” in the conditions of a three-week experimental oxalate nephrolithiasis was accompanied by characteristic signs of facilitating the course of the pathology and contributed to a decrease in the proportion of large calculi in the kidneys.
Clinical efficacy of acotiamide in patients with functional dyspepsia: results of a multicenter study
Authors: Bakulin I. G. , Khlynov I. B. , Sablin O. A. , Pakhomova I. G. , Pavlova N. V. 
Published: August 2023

Introduction. Despite the high prevalence of functional dyspepsia (FD), the question of effective treatment of this pathology remains open. This underlines the relevance of new approaches in the treatment of FD and the introduction of the drug Dyspevict® (acotiamide), a prokinetic with a new mechanism of action, into clinical practice to alleviate symptoms and improve the quality of life of patients with FD.Aim. Evaluate the efficacy and safety of the use of acotiamide in patients with FD with postprandial distress syndrome (PDS).Materials and methods. 389 patients were randomized in a 1:1 ratio into two groups. Patients of the first group took acotiamide, patients of the second group – placebo. Study drugs were taken orally for 4 weeks. The main criterion for the effectiveness of treatment was the “response to therapy”, assessed by patients on a 7-point Likert scale. Secondary efficacy criteria were: complete regression or relief of symptoms of FD with PDS, improvement in the quality of life of patients, which was assessed on the basis of the Nepean short dyspepsia index.Results and discussion. After 4 weeks, “response to therapy” was observed in 143/193 (74.1%) patients in the acotiamide group compared with 98/189 (51.9%) patients in the placebo group (p < 0.001). Therapy with Acotiamide, in contrast to placebo, showed a complete regression and relief of some symptoms of FD with PDS. Also, after the use of acotiamide, there was an improvement in well-being and quality of life in 172/194 (88.7%) patients compared with 131/189 (69.3%) patients in the placebo group (p < 0.001).Conclusion. The results of the conducted clinical study allow us to conclude that acotiamide is an effective treatment for FD with PDS in adults. The safety profile of the drug is comparable to placebo.
Performance evaluation of biocoagulant for the effective removal of turbidity and microbial pathogens from drinking water
Authors: Nigussie Zenebe , Habtu Nigus Gabbiye 
Published: August 2023

Abstract

In this study, Moringa seeds, aloe vera leaves, and cactus leaves were used as biocoagulants for the treatment of drinking water. The effects of coagulant type, coagulant dosage, and pH were studied on the quality of the treated water. Response surface methodology was used to predict and optimize the parameters. The standard Six Jar test was used to measure the performance of coagulants. Three mixing modes were used in the jar test: quick mixing at 1 min at 120 rpm, slow mixing for 19 min at 40 rpm, and 15 min settling. The characterization results showed that extracts of Moringa seeds, aloe vera leaves, and cactus leaves contain 43.95 ± 0.49, 13.9 ± 0.42, and 10.94% ± 0.37 protein, respectively. It was revealed that coagulant type, coagulant dosage, and the interaction between (coagulant type (MS-SC and AV-SC) and pH) were significant (p &lt; 0.05) for turbidity removal. Jar test results showed a removal efficiency of turbidity 98.83%, and 98.74% and 69.83% using MS-SC, and AV-SC and Ca-SC bio, respectively. These results imply that the three coagulants can be considered as effective, low-cost, and eco-friendly resources for the treatment of drinking water in rural communities of Ethiopia where access to clean water is scarce.
Evaluating water policies under the changing conditions of climatic variables in North Khorasan Province, Iran
Authors: Azizi Asiyeh , Mehrabi Boshrabadi Hossein , Zare Mehrjerdi Mohammad Reza 
Published: August 2023

Abstract

The paper aimed to evaluate the impacts of water pricing and quota policies under changing climatic conditions on the major production factors using economic-biophysical modeling. The data were collected by 382 questionnaires focusing on wheat, barley, cotton, alfalfa, and sugar beet crops in the 2017–2018 cropping year in North Khorasan Province, Iran. Climate change scenarios were defined as wet, moderate, and dry scenarios resulting from precipitation changes. The results showed that climate change scenarios reduce the total irrigated area of crops and total water used. Due to the effect of precipitation on crop yield, dry and moderate climate changes reduce the total gross income, while wet climate changes increase it. The scenarios of quota and pricing policies were then applied under climate change scenarios. The amount of water conserved by applying the quota policy was equal to the quota rate, while the impact of the pricing policy varied depending on the type of climate change. The highest amount of water conserved belonged to the conditions of dry climate change in Atrak and Central Desert catchments, which was about 6.8–8.6 and 3.83–14.48%, respectively. As the climate moves toward drought conditions in this province, the implementation of such policies can partially protect water resources.
Simulating two Algerian cities' desalination plants coupled with solar energy systems using TRNSYS
Authors: Irki Sara , Albright Edet , Merzouk Nachida Kasbadji , Hanini Salah , Barkaoui Sami , Benaissa Mhamed , Ghernaout Djamel , Elboughdiri Noureddine 
Published: August 2023

Abstract

Our study aimed to design a prototype for a desalination unit coupled with a solar collector, utilizing TRNSYS 16, to address the needs of both Bouzaréah in northern Algeria and Ghardaïa in southern Algeria. The desalination unit is composed of vacuum membrane distillation (VMD) coupled with a solar collector, and the photovoltaic has been designed according to the climatic conditions of each region. In this work, the approach adopted is to integrate a model developed in the literature into a simulation environment (TRNSYS) coupled with the CODE-BLOCKS compiler and FORTRAN programming language to create a new component (i.e., VMD process). Simulation results showed that the optimum permeation flux obtained through the desalination unit is relatively higher in Ghardaïa than in Bouzaréah, with a flow exceeding 30 kg/h.m2. The permeation flux and the power to load reached their maximum values with the charge of solar irradiation 48 kg/h.m2 and 6300 kJ/h, respectively, for Ghardaïa at the sun irradiation value 800 W/m2 and temperature of 34 °C. Results showed that Ghardaïa had a higher GOR value than Bouzaréah over the year (10.947 vs. 8.3389). Moreover, both locations recorded thermal recovery ratio values exceeding 1, indicating the high efficiency of the desalination unit.
General provisions of the substantiation of functional safety of intelligent systems in railway transportation
Authors: Shubinsky I. B. , Rozenberg E. N. 
Published: August 2023

Aim. The paper aims to solve the problem of objective and confident functional safety (FS) evaluation of intelligent control systems (ICS). As regards ICS, the conventional methods, due to their particular features, do not allow for a sufficiently confident estimation of the actual state of FS. The above features include primarily the nondistinct architecture of ICS and the changing connections between the system elements.Methods. Substantiating ICS FS requires using the complete arsenal of known methods and means recommended in GOST 33432-2015 [1], including managerial measures defined by the requirements for the safety policy, program and case. The authors have analysed the capability to prove ICS FS using experimental, expert, analytical, technological, and simulation-based methods. The limitations of some methods as regards ICS FS substantiation have been established.Results. The authors suggest a heuristic graph-based semi-Markov (Markov) method of proving system FS. For the purpose of substantiating ICS FS, it is recommended using the heuristic graph-based method combined with the technological method defined in GOST R IEC 61508 [2–4]. They don’t only allow confidently evaluating the FS of intelligent systems, but developing recommendations for achieving acceptable safety levels of such systems.
The Emerging Role of Heat Shock Proteins in Nasopharyngeal
Carcinoma: A Review
Authors: Ghavidel Farideh , Shahri Razieh Moalef , Javid Hossein , Rezagholinejad Nastaran , Hashemy Seyed Isaac 
Published: August 2023

Abstract:
Several investigations have revealed that nasopharyngeal carcinoma (NPC),
earlier known as lymphoepithelioma, originates from the nasopharynx epithelium (NPE).
The global NPC incidence and mortality distribution reports have reported very high
rates (more than 20-30 men per 100,000 men and 10 women per 100,000). Genetic background susceptibilities, Epstein-Barr virus (EBV), and their complex interaction are expressed as the pathophysiology. Also, radiotherapy of locoregional lesions is the main
treatment for NPC because of the extremely radiosensitive feature of the non-keratinizing variety. On the other hand, surgical intervention might be used for recurrent situations, while simultaneous radiation and chemotherapy for advanced stages are preferable.
Since specific disease symptoms do not appear early, biomarkers should be identified to
facilitate diagnosis. As overexpression of heat shock proteins (HSPs) has been observed
in various cancers, they can be a promising candidate biomarker for many malignancies.
The purpose of this study was to peruse different pathogenic roles of a panel of HSPs, including their diagnostic, preventive, and remedial role in NPC, which may provide the basis for future discoveries of novel HSP-based biomarkers of NPC.
Garlic against Heart-related Ailments: Chemistry, Pharmacology, and Future
Perspective
Authors: Chaurasia Pankaj Kumar , Bharati Shashi Lata , Singh Sunita 
Published: August 2023

Background:
Allium sativum L. (Garlic) is a well-recognized plant of great nutraceutical
value with pharmacological evidences. It is full of dietary as well as pharmaceutical properties and
has been used in traditional medications for a long time. It is known for good antioxidant, antifungal,
antibacterial, anti-diabetic, anti-inflammatory, anticancer, and antiviral effects, along with other
therapeutic roles in cardiovascular diseases, anti-atherosclerotic, antihypertensive, anti-thrombotic,
blood pressure, bone and skin related problems etc.

Objective:
Considering the potential of garlic in the treatment of cardiovascular/heart-related diseases,
the main objective of this study was to prepare a subject-centric mini-review focusing on its
chemistry and pharmacology in heart-related issues.

Methods:
In order to prepare this mini-review article, an extensive online literature search was performed
to find out the most recent studies related to this topic. These studies were briefly reviewed,
assessed, and discussed to explore the possible capability of garlic for the cure of cardiovascular
problems.

Result:
Several experiments on mice models, rat models as well as on humans show the effective
role of various forms of garlic in cardiovascular or heart-related ailments. After reviewing the available
publications on garlic in heart-related issues, authors found that garlic and its sulfur (S)-based
organic constituents may have advantageous applications in the treatment of cardiovascular diseases.
Palladium-catalyzed Cross-coupling of 2-Benzo[b]thiophene or 2-
Benzo[b]furan Aluminum with Heteroaryl or Alkynyl Bromides for the
Synthesis of 2-Hetroaryl or Alkynyl Benzo[b]thiophene or Benzo[b]furan
Derivatives
Authors: Liang Meng , Pu Jiaxia , Jia Xiaoying , Han Lirong , Li Qinghan 
Published: August 2023

Abstract:
An alternative method for the synthesis of 2-heteroaryl or alkynyl benzo[b]thiophene or furan
derivatives via direct palladium-catalyzed cross-coupling of 2-benzo[b]thiophene or furan aluminum
with heteroaryl or alkynyl bromides, respectively, has been successfully developed. This case is
remarkable as the same catalytic system could simultaneously produce either 2-substituted benzo[
b]thiophene or furan derivatives.
Herbal Technological Prospects of Morus nigra L.: A Systematic
Patent Analysis Review
Authors: Alves Larissa Pereira , dos Santos Widson Michael , de Souza Myla Lôbo , Rolim Larissa Araújo , Rolim-Neto Pedro José 
Published: August 2023

Background:
Morus nigra L. is a plant with significant potential for drug development due to the presence of numerous bioactive compounds in its various parts.

Objectives:
This article aims to compile the technological perspectives of Morus nigra L. towards drug development and therapeutic indications based on registered patents in databases.

Methods:
The study analyzed patents published within the last five years, focusing on products derived from different parts of the Morus nigra L. plant. Patent databases such as the European Patent Office (EPO), the United States Patent and Trademark Office (USPTO), the World Intellectual Property Organization (WIPO), and the National Institute of Industrial Property Databases (INPI) were examined.

Results:
A total of 45 patents were categorized by country of origin, type of applicant, extraction method, and therapeutic indications. China had the highest number of patent filings (43.48%), and private companies were the primary technology patent holders (38.64%). Noteworthy extraction methods included ultrasound-assisted extraction, decoction, infusion, and maceration. The most utilized plant parts were leaves (44.44%), followed by fruits (35.56%), root bark (15.56%), and stems (4.44%). The main therapeutic indications identified were the treatment of hyperglycemia and dyslipidemia (43.33%), along with digestive problems, cosmetics, nutrition, and cleaning applications.

Conclusion:
The study of patents covers discoveries and advancements often absent in scientific articles, making a review focused on this advanced information crucial for expanding existing scientific knowledge. Even if some therapies have been explored previously, patents can reveal innovative approaches and fresh perspectives that contribute to sustained scientific progress.
An Oxidative Stress Study on Curcumin and NanoCurcumin against
Aluminum Phosphide-induced Kidney Injury in Rats: The Role of
SIRT1/FOXO3 Signaling Pathway in Nephrotoxicity
Authors: Ghasemi Hassan , Manesh Seyde Farnaz Motevali , Kheiripour Nejat , Asl Sara Soleimani , Jouzdani Ali Fathi , Ranjbar Akram , Abdolvahab Mohadeseh Haji 
Published: August 2023

Introduction:
In this study, we have investigated the aluminium phosphide (ALP) toxicity on
Renal Function and oxidative stress in kidney tissue of male rats and the possible protective role of Curcumin
and nanoCurcumin against ALP-induced nephrotoxicity.

Methods:
Thirty-six adult male rats were divided into 6 groups (n=6). ALP (2 mg/kg oral administration)
and control groups received Curcumin and nanoCurcumin (oral administration 100 mg/kg) or
without it. After seven days of treatment, kidney parameters, oxidative stress biomarkers, and expression
level of sirtuins1 (SIRT1)/Forkhead box protein O1 (FoxO1) pathway genes were evaluated in kidney
tissue. In addition, histopathological changes in the kidney tissues were assayed.

Results:
In the ALP group, compared to the control group, lipid peroxidation levels, urea, and creatinine
were increased, and total antioxidant capacity and thiol groups decreased significantly p < 0.05. In Curcumin
and nanoCurcumin groups compared to the ALP group, lipid peroxidation and creatinine decreased
significantly p < 0.05. Also, Curcumin and nanoCurcumin improved the tissue damage caused
by ALP. NanoCurcumin modulated the effect of ALP on the gene expression levels in SIRT1/FoxO1.

Conclusion:
The present study showed that ALP intoxication in kidney tissue can induce oxidative
damage. Moreover, Curcumin and nanocurcumin, as potential antioxidants, can be effective therapeutics
in ALP-induced nephrotoxicity.
Thermal Characteristics of Oil Film in Critical Lubrication State of Heavy
Hydrostatic Bearing
Authors: Yanqin Zhang , Ye Wu , Jiabao Li , Mulan Wang , Zhen Quan 
Published: August 2023

Background:
Lubrication failure has always been a concern in the research of heavy hydrostatic
bearings. A preliminary study found that under a certain working condition, the heavy hydrostatic
bearing will appear in the condition of zero local flow of oil film, which is called a critical lubrication
state. It produces a significant thermal accumulation effect and affects the lubrication performance of
the bearing.

Objective:
This paper takes Q1-205 double rectangular cavity hydrostatic thrust bearing as the research
object and adopts the research method combining theoretical analysis, simulation, and experimental test
to analyze the temperature rise and characteristics of the bearing when it is in critical lubrication state
under different working conditions.

Methods:
The finite volume method is used to simulate the critical lubrication state under the condition
of common load and rotating speed, and the corresponding operating parameters of the critical lubrication
of heavy static support are obtained.

Results:
It is found that when the oil film is in the critical lubrication state, the low temperature zone is
concentrated at the bearing position of the oil film, while the high temperature zone is concentrated at
the counter-current side sealing edge

Conclusion:
The oil film's local temperature rise is intensified, and the heat accumulation phenomenon
is serious because the heat cannot be taken away in time.
Therapeutic Effect of Chitosan-Zinc Oxide Nanoparticles on Acute Kidney Injury Induced by Gentamicin in Wistar Rats
Authors: Saad Dalia Yousry , Khalil Hadeer Adel , Farouk Asmaa E. , Soliman Amel M. , Mohamed Ayman Saber 
Published: August 2023

Background:
Gentamicin (GM) is an antibiotic frequently used to treat severe gram-negative infections. However, due to nephrotoxicity, its clinical application is restricted. Several lines of evidence indicate that free radicals are important mediators of gentamicin nephrotoxicity. Therefore, the purpose of this research was to examine the potential antioxidant therapeutic value of ZnO-chitosan nanoparticles on gentamicin-induced nephrotoxicity.

Methods:
Twenty-four rats were divided into four groups (6 rats/group). All groups except group 1 were injected with gentamicin (100 mg/kg body weight i.p.) for eight days. On day 9, rats of groups 1 and 2 were administrated distilled water, and those of groups 3 and 4 were administrated 1/10 and 1/20 LD50 of ZnO-CS-NPs continuously for 30 days.

Results:
Treatment with ZnO-CS NPs caused a significant decrease in urea, creatinine, uric acid, sodium, potassium, chloride, microalbumin, and malondialdehyde levels; this was accompanied by a significant increase in kidney glutathione reduced, nitric oxide, superoxide dismutase, glutathione S-transferase, and catalase.

Conclusion:
The findings of the current study revealed that ZnO-CS NP ameliorated kidney injury against gentamicin induced-acute kidney injury in rats by its antioxidant properties.
Pozyskiwanie energii – technologie wodorowe Wodór z biomasy i odpadów
Authors: Siekierski Maciej , Ryś Piotr , Wieczorek Anna 
Published: August 2023

Polityka Unii Europejskiej od lat nastawiona jest na promowanie źródeł energii, które nie degradują środowiska. Takim źródłem energii może być wodór. Celem artykułu jest przybliżenie czytelnikom metod pozyskiwania wodoru z biomasy i niektórych odpadów oraz określenie jego koloru. W Unii Europejskiej przypisuje się temu pierwiastkowi różne kolory – zielony, różowy, żółty, niebieski, turkusowy, biały, szary, brązowy i czarny. Kolor zależy od źródła i metody pozyskania. Wodór, jako źródło energii uznawanej za przyjazną środowisku, powinien mieć kolor zielony, różowy lub niebieski. Słowa kluczowe: wodór, biomasa, odpady, odnawialne źródła energii