bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extreme temperature exposure increases the risk of preterm birth in women with abnormal pre-pregnancy body mass index: a cohort study in a southern province of China
Authors: Qiu Jialing , Liang Zhijiang , Yi Jing , Xie Lulu , Xiang Qianqian , Luo Xianqiong , Zhao Qingguo 
Published: July 2023

BackgroundPrior literature has found that extreme temperature exposure is associated with preterm birth (PTB). However, current evidence provides heterogeneous conclusions, and data on extreme cold and across different pre-pregnancy body mass index (BMI) statuses are limited.MethodsWe conducted a population-based retrospective cohort of 251,257 women between 2014 and 2017 in Guangdong, China, to evaluate whether the association between extreme temperature exposure and PTB varied in pre-pregnancy BMI status. Participants were divided into three categories based on pre-pregnancy BMI: underweight (BMI &lt; 18.5 kg/m2), normal weight (18.5–23.9 kg/m2), overweight or obesity (≥ 24.0 kg/m2). We fitted Cox proportional hazards models to assess the association between daily mean temperature and PTB at each trimester for each BMI category separately. The hazard ratios (HRs) at the 5th and 95th percentiles of temperature (defined as low and high temperatures respectively) were provided using the median temperature at each trimester as a reference.Results58,220 (23.2%) were underweight, and 27,865 (11.1%) were overweight or obese. Of the 251,257 women, 18,612 (7.41%) had PTB delivery. Both low-and high-temperature exposure increased the risk of PTB in the third trimester, while cold exposure mostly mitigated the risk for the first and second trimesters. The association with low temperature was the strongest in the third trimester, especially for underweight women (HR: 1.825; 95%CI: 1.529 ~ 2.179), while the association with high temperature was the strongest also in the third trimester, especially for obese or overweight women (HR:1.825; 95%CI:1.502 ~ 2.218). Furthermore, the attributable fractions of PTB risk in the third trimester were estimated as 5.59% (95% CI: 3.58, 7.98%) for cold exposure among underweight women and 3.31% (95% CI: 2.01, 4.88%) for hot exposure among overweight or obese women.ConclusionExposure to either low temperature in the third trimester or high temperature during pregnancy was associated with a higher risk of PTB. Moreover, pre-pregnancy BMI status might affect the susceptibility of pregnant women. Such findings would be useful to develop targeted measures for vulnerable populations.
Prediction of the risk of cytopenia in hospitalized HIV/AIDS patients using machine learning methods based on electronic medical records
Authors: Huang Liling , Xie Bo , Zhang Kai , Xu Yuanlong , Su Lingsong , Lv Yu , Lu Yangjie , Qin Jianqiu , Pang Xianwu , Qiu Hong , Li Lanxiang , Wei Xihua , Huang Kui , Meng Zhihao , Hu Yanling , Lv Jiannan 
Published: July 2023

BackgroundCytopenia is a frequent complication among HIV-infected patients who require hospitalization. It can have a negative impact on the treatment outcomes for these patients. However, by leveraging machine learning techniques and electronic medical records, a predictive model can be developed to evaluate the risk of cytopenia during hospitalization in HIV patients. Such a model is crucial for designing a more individualized and evidence-based treatment strategy for HIV patients.MethodThe present study was conducted on HIV patients who were admitted to Guangxi Chest Hospital between June 2016 and October 2021. We extracted a total of 66 clinical features from the electronic medical records and employed them to train five machine learning prediction models (artificial neural network [ANN], adaptive boosting [AdaBoost], k-nearest neighbour [KNN] and support vector machine [SVM], decision tree [DT]). The models were tested using 20% of the data. The performance of the models was evaluated using indicators such as the area under the receiver operating characteristic curve (AUC). The best predictive models were interpreted using the shapley additive explanation (SHAP).ResultThe ANN models have better predictive power. According to the SHAP interpretation of the ANN model, hypoproteinemia and cancer were the most important predictive features of cytopenia in HIV hospitalized patients. Meanwhile, the lower hemoglobin-to-RDW ratio (HGB/RDW), low-density lipoprotein cholesterol (LDL-C) levels, CD4+ T cell counts, and creatinine clearance (Ccr) levels increase the risk of cytopenia in HIV hospitalized patients.ConclusionThe present study constructed a risk prediction model for cytopenia in HIV patients during hospitalization with machine learning and electronic medical record information. The prediction model is important for the rational management of HIV hospitalized patients and the personalized treatment plan setting.
Wakakosha “You are Worth it”: reported impact of a community-based, peer-led HIV self-stigma intervention to improve self-worth and wellbeing among young people living with HIV in Zimbabwe
Authors: Ferris France Nadine , Byrne Elaine , Nyamwanza Owen , Munatsi Vongai , Willis Nicola , Conroy Ronan , Vumbunu Sylivia , Chinembiri Moud , Maedziso Samantha , Katsande Munyaradzi A. , Dongo Takudzwa A. , Crehan Eimear , Mavhu Webster 
Published: July 2023

IntroductionSelf-stigma—negative self-judgements or core beliefs—can result in feelings of shame, worthlessness and self-blame, and impacts social interaction, mental health and health service utilization among people living with HIV (PLHIV). Few interventions target self-stigma among PLHIV and, to our knowledge, none until now for adolescents and young people LHIV (AYPLHIV) in sub-Saharan Africa. We present qualitative findings on the perceived impact of a self-stigma intervention (Wakakosha, “You are Worth it”).MethodsThe Wakakosha intervention adopted inquiry-based stress reduction (IBSR) at its core—a unique way of identifying and questioning deeply rooted self-stigma, combined with mindfulness, meditation and creativity. The intervention consisted of 16 × 3 hour group sessions. Supporting the intervention was a 156-page activity journal. We utilized a qualitative enquiry to explore the perceived impact of the intervention at various time points between November 2021 and November 2022, with 62 participants (n = 32 female). Discussions explored experiences of being involved in the intervention and any reports on changes in relation to self-stigma and shame. Additionally, we reviewed intervention documentation and creative elements. A thematic analysis guided generation of themes across all data sources.ResultsBoth intervention participants and coaches described the transformative effect of the intervention, detailing their experiences before and after. Main themes that emerged were positive changes around: self-confidence, self-agency, sense of purpose/meaning, body positivity, improved communication and personal/family relationships and, forgiveness. The intervention also transferred a set of practical skills on self-inquiry, mindfulness, meditation and creativity that continued to be used in participants’ daily lives.ConclusionThe Wakakosha intervention, using IBSR supported by music, creativity, writing and mindfulness techniques, showed potential for reducing self-stigma and improving self-worth among AYPLHIV. It also transferred practical skills to intervention participants and peer coaches, building their capacity to support others and deal with life challenges beyond HIV. The next phase is to continue supporting the young people to ensure fidelity as the peer coaches deliver the intervention to others. Study results indicate that culturally and practically, interventions to reduce self-stigma and/or improve self-worth operate at various levels and need to be designed and assessed at each level.
Applying RE-AIM to evaluations of Veterans Health Administration Enterprise-Wide Initiatives: lessons learned
Authors: Kenney Rachael R. , Klocko Robert P. , Manheim Chelsea E. , Mog Ashley C. , Young Jessica P. 
Published: July 2023

IntroductionThe United States Veterans Health Administration (VHA) Office of Rural Health funds Enterprise-Wide Initiatives (system-wide initiatives) to spread promising practices to rural Veterans. The Office requires that evaluations of Enterprise-Wide Initiatives use the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework. This presents a unique opportunity to understand the experience of using RE-AIM across a series of evaluations. The authors conducted a study to document the benefits and pitfalls of using RE-AIM, capture the variety of ways that the team captured the elements of RE-AIM, and develop recommendations for the future use of RE-AIM in evaluation.Materials and methodsThe authors first conducted a document review to capture pre-existing information about how RE-AIM was used. They subsequently facilitated two focus groups to gather more detailed information from team members who had used RE-AIM. Finally, they used member-checking throughout the writing process to ensure accurate data representation and interpretation and to gather additional feedback.ResultsFour themes emerged from the document review, focus groups, and member checking. RE-AIM: provides parameters and controls the evaluation scope, “buckets” are logical, plays well with other frameworks, and can foster collaboration or silo within a team. Challenges and attributes for each RE-AIM dimension were also described.DiscussionOverall, participants reported both strengths and challenges to using RE-AIM as an evaluation framework. The overarching theme around the challenges with RE-AIM dimensions was the importance of context. Many of these benefits and challenges of using RE-AIM may not be unique to RE-AIM and would likely occur when using any prescribed framework. The participants reported on the RE-AIM domains in a variety of ways in their evaluation reports and were not always able capture data as originally planned. Recommendations included: start with an evaluation framework (or frameworks) and revisit it throughout the evaluation, consider applying RE-AIM PRISM (Practical Robust Implementation Framework) to gain a broader perspective, and intentionally integrate quantitative and qualitative team members, regardless of the framework used.
Case report: The intrauterine suture surgery—an original method in the treatment of old uterine false passage
Authors: Song Xiaolei , Na Re , Peng Nianghai , Cao Wenming , Ke Yan , Liu Ping , Chen Chunlin 
Published: July 2023

ObjectiveTo introduce an effective approach using the hysteroscopy system for patients with old uterine false passage after a failed conservative treatment.Materials and methodsThis study presents the case of a 34-year-old woman who was treated in the Department of Gynecology of Shenzhen Integrated Traditional Chinese and Western Medicine Hospital in 2018 with the complaint of “menstrual volumereduction for 2 years after abortion.” A hysteroscopy was performed to make a clear diagnosis: (1) uterine cavity adhesion and (2) old uterine false passage. After the separation of adhesions, the patient was treated with estradiol and progesterone in sequence (estradiol valerate 3 mg, b.i.d., oral for 21 days; and dydrogesterone tablets 10 mg, b.i.d., oral for the second half of the cycle) for 3 months. After the review of the hysteroscopy results, it was found that there was no improvement in the old false passage; therefore, a suture and knotting surgery under hysteroscopy was performed to treat the old false passage in the uterus within 10 min, and the intraoperative blood loss was 2 ml. The patient was discharged 24 h postoperatively without any adverse perioperative complications.ResultsTwo months after the operation, the review of the hysteroscopy results showed that the old false passage in the uterus disappeared. After the 6-month follow-up, the menstrual volume increased compared with the previous one, close to the normal menstrual volume, and the patient experienced no pain and menstrual discomfort. The patient was lost to follow-up and was contacted again in 2022. It was found out that in 2019, she was pregnant with a baby boy who is now 3 years old and healthy.ConclusionThe intrauterine suture surgery presents a clear visual ﬁeld to old uterine false passage after a failed conservative treatment. In patients with old uterine false passage suffering from reduced fertility, the intrauterine suture surgery can be a minimally invasive and effective alternative if the conservative treatment for old uterine false passage failed.
The Amplification and Activity Analysis of the Small Rubber Particle Protein (SRPP) Promoter of Eucommia ulmoides (EuSRPP) Revealed That Its Activity Was Regulated by MeJA, GA3, and Drought Pathways
Authors: Zhao Huimin , Yao Xinzhuan , Lu Litang 
Published: July 2023

As an important temperate gum source plant, Eucommia ulmoides is widely distributed in China, but the low yield of Eucommia ulmoides gum considerably affects its application as a natural rubber in practical production. The small rubber particle protein (SRPP) gene is an influential participant in the Eucommia ulmoides gum biosynthesis process, and its expression affects the gum content. In this study, the promoter activity of the Eucommia ulmoides SRPP (EuSRPP) gene was analyzed by molecular biology and bioinformatics. In order to understand the molecular regulation mechanism of the EuSRPP genes at the transcriptional level, we first obtained the promoter sequences of the EuSRPP1, 3, 4, 5, 6, and 7 genes via genome walking and PCR amplification experiments. Then, the T3 generation of the transgenic homozygous line was obtained via a genetic transformation of Arabidopsis thaliana mediated by Agrobacterium. The six EuSRPP promoters were expressed in transgenic plants and were stably expressed in the leaves, pollinated flowers, and mature pods. As the transgenic plant grows and develops, promoter activity in the root is barely expressed. In addition, after the transgenic Arabidopsis was treated with methyl jasmonate (1 mmol/L MeJA), gibberellin (1 mmol/L GA3), and drought (20% PEG6000), the activity expression of the six EuSRPP promoters increased first and then decreased. The difference, however, is that EuSRPP1, 3, and 4 reach their strongest GUS activity at 3 h of plant treatment, while EuSRPP5, 6, and 7 reach their strongest activity at 6 h of treatment. Based on all experimental results, for the first time, it has been shown that the expression loci of the six EuSRPP gene promoters were relatively consistent. Second, the expression activity of the promoters of the six EuSRPP genes was different under MeJA, GA3, and drought treatment, suggesting that the promoter activity of the EuSRPP genes was regulated by endogenous hormones and drought pathways.
Economic Interdependence between Norway and The European Union Compared to Switzerland and The European Union
Authors: Reskiyah Emy Sri 
Published: July 2023

Norway and Switzerland have a history of being part of the European Union (EU) and eventually opting out. Though, as a part of the European Economic Area allows Norway to integrate and participate with the EU’s single market. Similarly, Switzerland can participate in and access the European single market through a set of bilateral agreements with the EU. Consequently, both countries must accept a set of rules by the EU. This paper aims to compare and examine the bilateral relations maintained between Norway and the EU compared to Switzerland and the EU in the field of economic cooperation namely the trade and investment sectors in the aftermath of the financial crisis. This paper incorporates two types of analysis. The first part uses quantitative methods of descriptive statistical analysis and is followed by strength, weakness, opportunities, and threat (SWOT) analysis. This paper demonstrates that the bilateral relations between Norway and the EU as well as for Switzerland and the EU have created conditions of interdependence for both the EU and its partners, namely, Norway and Switzerland.
Keywords— European Union, Interdependence, Norway, Switzerland
Uji Kestabilan Fisik Krim Antijerawat Ekstrak Etanol Daun Sagu (Metroxylon sagu Rottb) dan Uji Aktivitas Bakteri Terhadap Propionibacterium acnes dan Staphylococcus epidermidis
Authors: Isrul Muhammad , Hasanuddin Silviana , Dewi Citra , Alimasi Asnur 
Published: July 2023

Daun sagu (Metroxylon sagu Rottb) mengandung senyawa metabolit sekunder seperti alkaloid, flavonoid, saponin, fenol, steroid, dan tanin yang berfungsi sebagai antibakteri. Untuk meningkatkan aktivitas dalam pemanfaatan potensi dari daun sagu, maka dibuat dalam bentuk sediaan yang praktis dan mudah digunakan yaitu dalam bentuk krim. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri sediaan krim ekstrak daun sagu (Metroxylon sagu Rottb) terhadap penghambatan pertumbuhan bakteri Propionibacterium acnes dan Staphylococcus epidermidis sebagai antijerawat. Sampel daun sagu (Metroxylon sagu Rottb) diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%, kemudian dibuat formulasi dalam bentuk sediaan krim dengan konsentrasi ekstrak 2,5%, 5%, dan 10% Selanjutnya evaluasi fisik sediaan yaitu meliputi uji organoleptik, uji pH, uji homogenitas, uji daya sebar, dan uji viskositas. Hasil penelitian menunjukkan evaluasi fisik sediaan krim antijerawat ekstrak daun sagu (Metroxylon sagu Rottb) dengan kosentrasi 2,5%, 5%, dan 10% memiliki warna, bau dan bentuk yang stabil, sediaan yang homogen, viskositas sediaan yang baik , dan nilai pH yang dapat diterima. Sediaan ini dapat menghambat pertumbuhan bakteri Propionibacterium acnes pada kosentrasi 2,5% sebesar (4,87 mm) kategori lemah, 5% sebesar (7,87 mm) kategori sedang dan 10% sebesar (12,60 mm) kategori kuat. Sedangkan pada bakteri Staphylococcus epidermidis yaitu 2,5% sebesar (5,07 mm) kategori sedang, 5% sebesar (7,07 mm) kategori sedang dan 10% sebesar (10,53 mm) kategori kuat.
Produksi Sukaku (Susu Kacang Kurma) sebagai Nutrisi dalam Pencegahan Stunting Di Desa Borisallo, Gowa
Authors: Maryam St. , Abidin Zainal , Rahmawati Rahmawati 
Published: July 2023

Salah satu sumber pangan lokal yang melimpah di desa Borisallo adalah kacang tanah yang dapat diolah menjadi suatu produk yang memiliki nilai guna yang tinggi seperti produk susu. Susu kacang tanah menjadi suatu alternatif untuk meningkatkan asupan gizi dalam mengatasi masalah stunting. Stunting kini menjadi salah satu prioritas yang ditangani pemerintah secara nasional, termasuk di Kabupaten Gowa. Desa Borisallo Gowa. Adapun tujuan dari kegiatan ini adalah memberikan pemahaman tentang pangan dan gizi serta nutrisi dan manfaat kacang tanah yang dapat digunakan untuk mencegah stunting; meningkatkan pemanfaatan dan pengolahan kacang tanah melalui pembuatan susu kacang tanah yang dapat diformulasikan dengan kurma; selain itu hasil kebun kacang tanah saat ini dapat menjadi sumber pendapatan yang optimal dalam memajukan ekonomi keluarga. Metode yang digunakan dalam pelatihan ini adalah metode partisipatif, yaitu melibatkan peran serta mitra dalam kegiatan pemberian materi, diskusi tanya jawab dan praktek. Kegiatan yang sudah dibuat dan disepakati dilakukan dengan metode pelatihan dengan strategi pengembangan produk kacang tanah serta perancangan pembuatan kemasan produk. Melalui kegiatan ini, mitra dalam hal ini ibu-ibu rumah tangga dapat berperan aktif dalam melaksanakan kegiatan pembuatan produk SUKAKU (Susu Kacang Kurma) sehingga dapat dikonsumsi oleh masyarakat khususnya anak-anak balita untuk mencegah dan mengatasi gejala stunting. Dari hasil kegiatan, peserta dapat membuat sendiri minuman SUKAKU dan menikmati rasa khas dari kombinasi kacang dan kurma yang memiliki kandungan nutrisi yang dapat menambah nilai gizi khususnya bagi balita untuk mencegah stunting. Dari hasil evaluasi, diperoleh data bahwa terjadi peningkatan secara signifikan pengetahuan peserta setelah melakukan pra dan post test, yaitu dari 70% menjadi 95%. Dari hasil kuesioner terhadap penilaian produk minuman SUKAKU, para koresponden sangat senang dengan adanya produk ini, menikmati rasanya dan berencana untuk membuat dan mengkonsumsi kembali minuman susu kacang kurma.
Edukasi Pemilahan Sampah Sejak Dini di SDN 1 WONGAYA GEDE
Authors: Dewi Luh Willa Yasmira , Kusnita Kadek Linda 
Published: July 2023

Sampah menjadi permasalahan serius yang sering dihadapi di lingkungan penduduk saat ini. Permasalahan lingkungan yang disebabkan oleh sampah menjadi problematika bersama. Pengetahuan masyarakat di Desa Wongaya Gede tentang sampah dan pengelolaannya masih minim. Fasilitas pendukung yang kurang turut memperburuk kondisi tersebut. Oleh karena itu penting untuk menumbuhkan kepedulian warga agar tidak sembarang membuang sampah serta mengedukasi bagaimana memilah sampah. Upaya menjaga lingkungan sekitar perlu dikenalkan sejak dini sehingga kami melakukan edukasi mengenai pemilahan sampah bagi siswa sekolah dasar di Desa Wongaya Gede, Kecamatan Penebel, Tabanan. Tujuan dari edukasi ini ialah untuk meningkatkan kesadaran dan kepeduliam siswa dalam kondisi pencemaran lingkungan akibat sampah, memberikan solusi melalui edukasi pentingnya menjaga kebersihan, memilih dan membedakan sampah organik dan anorganik serta memanfaatkan olahan sampah tersebut sehingga memiliki nilai ekonomis. Pemberian materi edukasi ini berupa pengertian sampah, jenis-jenis sampah, pentingnya pemilahan sampah untuk dilakukan, manfaat pemilahan sampah serta dampak bila tidak melakukan pemilahan sampah dengan benar. Bentuk nyata kegiatan ini berupa bantuan penyediaan fasilitas tempat sampah yang terpilah.
The Effect of Intellectual Capital on Financial Performance with Corporate Social Responsibility as Moderating Variable: Studies on Islamic Commercial Banks
Authors: Rusmawan Renanta Ivana Nanda , Setiawan Iwan , Ruhadi Ruhadi 
Published: July 2023

This study aims to determine the influence of Intellectual Capital and the moderating of Corporate Social Responsibility to financial performance of Islamic banks. The data in this study used secondary data using the IB reports for the years 2010-2021. The independent variable used is IC as measured by Human Capital Efficiency, Structural Capital Efficiency, and Capital Employed Efficiency, and Corporate Social Responsibility as moderating variable. While the dependent variable used is ROA and ROE as the measure of financial performance. This study uses multiple linear regression analysis with data panel models. The results showed that IC as measured by HCE has positive and no significant effect, SCE has positive and significant effect, and CEE has negative and significant effect on financial performance. and as a moderating variable, CSR negatively weakens the relationship between HCE and SCE and financial performance, while CSR positively strengthens the relationship between CEE and financial performance.