bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Food Additive Potential of the Rosa damascena Mill. (Isparta Rose): Vinegar with Probiotic Addition
Authors: Ertürkmen Pelin , Bulantekin Özcan , Alp Duygu 
Published: July 2023

Abstract
Rosa damascena Mill., named also 'Isparta rose', is grown in the province of Isparta in Turkey. It is an aromatic plant having sharp and intensive scent and rich in bioactive compounds. In the literature, it has been reported that Isparta rose has a potential as natural food additives. However, the application to be natural food additive has not been study detailed. Therefore, rose vinegar was produced by the traditional method in present study and analyzed reported. Moreover, by adding probiotic strains to these vinegars produced, quality characteristics of the vinegars such as physicochemical, microbiological and some bioactive compounds were determined during storage time. The presence of main aroma compound associated with a rose honey-like odor and volatile aroma compounds such as dodecene, tetradecanol, linalool as well as phenyl ethyl alcohol are determined in all the vinegars. The aroma components have increased the pleasant taste and acceptability of vinegars in terms of sensory properties. On the other hand, it is determined that various organic acids (93.43 mg/100 mL oxalic acid, 53.57 mg/100 mL propionic acid, 10.11 mg/100 mL fumaric acid) and aroma components produced by Lactiplantibacillus plantarum strain are significantly affected the lactic and acetic acid bacteria growth. Additionally, the fact that the strain has completed the storage period with 83.96% viability, it shows that the has including the required number of viable microorganisms for produced vinegar to be called a probiotic during this time. All the results showed that it has potential that vinegar with culture additives will also create an alternative to functional probiotic drinks.
Beautiful Mind: a meta-heuristic algorithm for generating minimal covering array
Authors: Esfandyari Sajad , Rafe Vahid , Pira Einollah , Yousofvand liela 
Published: July 2023

Abstract

Today, the application of meta-heuristic algorithms in solving problems is very important. This importance has led to the development of hundreds of types of meta-heuristic algorithms by researchers. The reason for the high number of such algorithms is that an algorithm may be superior to its competitors in a particular problem. Generating a test set in Combinatorial Testing (CT) is one of the thousands of problems that can be solved by meta-heuristic algorithms and hundreds of algorithms have been proposed in this regard. The main challenge in producing a test set in CT is becoming trapped in local optima that several solutions have been offered to overcome this problem. Since the proposed solutions are very slow in terms of time, it is still possible to produce better results by applying other solutions. Continuing our research in the field of CT, we have tried to present a new meta-heuristic solution called Beautiful Mind (BM), which simulates the human way to reach the answer. In fact, the proposed algorithm considers the human intelligence and emotional coefficient to find the answer. The evaluation results show that the proposed approach is much stronger than the existing solutions.
Emergency Medicine Research in Pakistan: Trends of publication and quality of evidence
Authors: Jawed Rida , Aftab Umaira , Soomar Salman Muhammad , Waheed Shahan 
Published: July 2023

Abstract

Background Emergency medicine has transitioned from developing to developed speciality in Pakistan. There is a need of study to provide insights into areas where most of the research has been done and to understand the areas where research initiatives needs to be directed. Through an in-depth analysis of the current literature, this study aims to identify gaps in emergency medicine research and to suggests area of deficiencies where further studies are required.Methods Emergency medicine related keywords and terms were searched to identify studies published from January 2012 to December 2021 (10 years) in online databases of PubMed, CINAHL, Cochrane and EBSCO. These studies were then filtered through our eligibility criteria. Author, year, study design/ article type, area of study / theme and quality of study were reported along with risk of bias and confounders.Results 150 articles were included in the review out of 871 following the eligibility criteria.Majority of the articles were published in the year 2020 (22.7%) followed by 2016 and 2017 (12% collectively) while the least studies were published in the year 2021 (1.3%). In the same time period, the most common study design was cross-sectional (40.7%) and the least common was mix-method/qualitative (1.3%) whereas, on account of risk of bias, 48% are rated moderately biased while 50% of the included articles had a strong (50%) risk of confounder, yet overall, in around 80% the quality of the paper is marked as predominantly moderate. The leading theme in the cross sectional and cohort studies and case reports was Infectious Diseases, whereas one mix-method study pertaining to Violence and trauma was published in 2021 and one qualitative study in 2015 was related to ethics.Conclusion Analyzing the types and themes of publications and assessing their quality will enable future researchers to focus on lesser explored topics or study designs in their respective areas of interest within emergency medicine.
Comparison of robotic single site cholecystectomy and conventional laparoscopic cholecystectomy using propensity score matching
Authors: JANG EUN JEONG , KANG SUNG HWA , KIM KWAN WOO 
Published: July 2023

Abstract
PURPOSE
To demonstrate the feasibility and potential of robotic single site cholecystectomy (RSSC), the study aimed to compare RSSC with conventional laparoscopic cholecystectomy (CLC).
METHODS
In total, 791 consecutive patients underwent CLC or RSSC in our center, between 2019 and 2022. After 1:1 propensity score matching, 117 patients for each group were selected.
RESULTS
After propensity score matching, the only statistically significant difference between CLC and RSSC was operative time, which was 29.15 ± 11.45 min in the CLC group versus 38.57 ± 12.59 min in the RSSC group (P < .001). Because the difference in surgical time between the two groups was minimal, it has little clinical relevance. Using cumulative sum analysis, the maturation phase of the total operation and docking times occurred after the 53rd case. To reduce bias, comparison of results with CLC and cases of RSSC was performed in the maturation phase, which revealed only total operative time as statistically significant (P < .001).
CONCLUSION
RSSC is a technically feasible and safe method for treating benign gallbladder diseases, with a relatively short learning curve and reasonable operation time.
Pseudogene CIDECP inhibits the migration and invasion of cervical cancer cells through the miR-29a-3p /NFATC4 axis
Authors: Feng Yujie , Jia Yan , Li Hui , Zhang Pengyu 
Published: July 2023

Abstract
Cervical cancer (CC) is one of the cancers that seriously affects the health and life of women. The dysregulated expression of long noncoding RNAs (lncRNAs) plays an important role in the progression of various cancers. To explore the functional roles of dysregulated lncRNAs in CC progressionand reveal its underlying molecular mechanisms. The differentially expressed lncRNAs were obtained by deep sequencing. RT‒qPCR assay was used to verify the expression levels of CIDECP, miR-29a-3p and NFATC4 in HeLa cells. The luciferase reporter assays and RT‒qPCR assays were used to verify the targeting relationship between CIDECP and miR-29a-3p as well as miR-29a-3p and NFATC4. Transwell assay, wound healing assay and MTT assay were used to detect the effects of CIDECP on the migration, invasion and cell viability of HeLa cells. The potential prognostic value of CIDECP in CC was predicted by bioinformatics analysis software. We found that pseudogene CIDECP was significantly downregulated in TNF-α-treated HeLa cells. The expression level of CIDECP in CC tissues was lower than that in adjacent tissues and was related to the CC stage. Lower expression of CIDECP was remarkably associated with worse prognosis in patients with CC. Cell function assays confirmed that CIDECP inhibited the migration, invasion and viability of HeLa cells and upregulated the expression level of NFATC4 by as a ceRNA of miR-29a-3p. This study demonstrated that the expression and the role of CIDECP in CC and provided molecular markers for the diagnosis and prognosis of CC.
The relationship between worker-occupation fit and cortisol concentration of hair and plasma among medical workers
Authors: Chen Xiaofang , Sun Ruican , Lv Keyao , Lan Yajia 
Published: July 2023

Abstract

Background With the transformation of job characteristics, Worker-occupation fit (WOF) is a significant protective factor for stress of workers. Cortisol is an essential hormone secreted by the hypothalamic-pituitary-adrenal axis and can fluctuate in the body under stress. The aim of this study was to explore the relationship between WOF and cortisol among medical workers. Methods A total of 161 medical workers take part in this cross-sectional study and 156 data were finally included in the analysis. Occupational stress was measured by the Depression, Anxiety, and Stress Scale (DASS-21), and WOF was surveyed by the Worker-Occupation Fit Inventory. The detection of hair and plasma cortisol concentration was carried out by automated Electrochemiluminescence immunoassay. Spearman correlation analysis and linear regression models after log transformation of data were used to analysis association between WOF and cortisol concentration of hair plasma among 156 Chinese medical workers. Results In this study, the hair cortisol concentration of female with high fit level was lower than that of women with low fit level (p = 0.025). The correlation analyses show that WOF was negative related to hair cortisol concentration (r=-0.185,p = 0.021), but not with plasma cortisol concentration (p > 0.05). The linear regression analysis show that WOF was negative associated with hair cortisol concentration in crude model (β=-0.192,p = 0.016) and adjusted model (β=-0.181,p = 0.022), but not with plasma cortisol concentration (p > 0.05). Conclusion WOF is negative correlated with hair cortisol concentration, but not with plasma cortisol concentration. The causal relationship between WOF and cortisol needs further exploration in future prospective study.
Intrarenal Resistive Index and Kidney Volume: Key Indicators of Early Diabetic Kidney Disease in Youth-Onset, Long-Duration Type 1 Diabetes
Authors: Yu Karen Mei-Ching , Lo Fu-Sung , Chou Yi-Hsuan 
Published: July 2023

Abstract
Background:
The aim of this study is to explore the potential of non-invasive, ultrasound-based markers—kidney volume (KV) and intrarenal resistive index (RI)—for predicting early onset ofdiabetic kidney disease (DKD). Additionally, we intend to assess the correlation between these ultrasound markers and specific serum inflammatory cytokines in patients with youth-onset and long-duration type 1 diabetes (T1D).
Methods: A cross-sectional study was conducted from May 2020 to October 2021 on adolescents and young adults with T1D (50 males and 59 females) for over 10 years. The cohort was divided into Group 1 (N=96, normoalbuminuria: UACR < 30 mg/g) and Group 2 (N=13, hyperalbuminuria: UACR ≥30 mg/g). Renal and Doppler ultrasound examinations were performed by a senior pediatric nephrologist. We also analyzed eight proinflammatory cytokines/chemokines (e.g., sCD40L, Fractalkine, IL-1β, IL-6, IP-10, TNF-α, VEGF-A and RANTES) in serum. Patient demographic and clinical data were retrospectively collected.
Results:
We enrolled 109 diabetic patients with a median age of 24.4 years, a median T1D duration of 17.0 years, and a median age of onset at 7.7 years. T1D patients with hyperalbuminuria demonstrated significantly higher intrarenal RI and larger KV than those with normoalbuminuria (Mann-Whitney U test, P< 0.05). Serum concentrations of sCD40L and IL-1β showed a positive correlation with left KV. Moreover, increased serum IL-6 and VEGF-A concentrations were associated with a rise in the average RI in both kidneys
Conclusions:
Non-invasive ultrasound biomarkers, specifically intrarenal RI and KV, show their potential for improving early detection of preclinical DKD in the patients living with long-duration T1D.
New estimates of poplar ecosystem carbon pools based on remote sensing and field surveys of forest carbon sinks
Authors: Yan Ru , Liu Shuqin , Li Mingfeng 
Published: July 2023

Abstract
Within the context of global climate change, carbon sequestration by poplar is receiving increasing attention, both in China and globally. However, factors including limited sample sizes, multiple data sources, and inconsistent methodologies have limited accurate estimates of carbon sequestration by poplar to only that of aboveground biomass (AGB) and belowground biomass (BLB) carbon pools; whereas the estimations of forest understory (LGB) and dead wood (KSB) remain uncertain. This study conducted a field campaign involving 123,385 monitoring plots and 163 carbon sink-specific standard plots. The results showed that the total carbon pool of the poplar ecosystem was 413.64 Tg C, of which 98.39% and 1.61% were stored in biomass and dead organic matter, respectively. The carbon densities of different carbon pools exhibited strong correlations with climate, with the carbon sequestration capacities of AGB and BLB first decreasing sharply and then increasing gradually with increasing mean annual temperature (MAT) and mean annual precipitation (MAP), following which they gradually stabilized after exceeding a certain threshold value. The rank of climate variables in terms of their influence on the remaining carbon pools was mean relative humidity (MRH) > MAT > MAP. The results also showed strong correlations between different carbon pools and altitude, slope degree, slope aspect, and slope position. This study provided updated estimates of the carbon pools of poplar ecosystems based on direct field measurements and can provide a valuable reference for the validation and parameterization of carbon models in China and globally.
Endoscopic Ultrasound Guided Gastric Botulinum Toxin Injections versus Glucagon like peptide 1 Receptor Agonist in weight loss. A Prospective randomized study
Authors: Gameel Asmaa , Altonbary Ahmed , Kyrillos Fady , Elbialy Aya 
Published: July 2023

Abstract
Purpose In this study, we compared safety, feasibility, and efficacy of Endoscopic Ultrasound (EUS) guided Botulinum toxin A (BTA) injection versus Glucagon like Peptide 1 (GLP-1) agonists in treatment of obesity. The two intervention techniques were paired with a number of lifestyle changes, such as a diet of 2000 calories per day for males and 1800 calories per day for women, and moderate daily cardiovascular exercise (at least 30 minutes, five days a week) for four months. Over the course of a 16-week follow-up period, body weight was measured.
Methods 40 patients were included in this study, 20 in each group. The 1st group underwent BTA injections via EUS, while the 2nd group received GLP 1 receptor agonist.
Results In the 1st group, there was a significant weight loss from (107.30±11.41 kg) at baseline to (94.75±12.65 kg) after 4 months of treatment (p value <0.001). In the 2nd there was significant weight loss from (123.28±17.17 kg) at baseline to (109.75±14.37 kg) after 4 months (p value <0.001). Significant reduction of BMI was reported in both groups after 4 months of treatment; 1st group, from (40.53±4.41 kg/m2) at baseline to (35.78±4.82 kg/m2) (p. value <0.001), 2nd group from (44.15±5.94 kg/m2) to (39.40±5.68 kg/m2) (p value <0.001).
Conclusion EUS guided BTA injections and GLP-1 RA receptor agonist injections both could be effective and safe procedures for treatment of obesity.
Trial registration: NCT05268627, initial release 27/1/2022
Motivational Strategies -informed workshop and Iranian EFL Teachers’ Cognition and Practices of Motivational Strategies
Authors: Exir Mina , Mostafazadeh Niloofar Sadat , Alibakhshi Goudarz 
Published: July 2023

Abstract
It is believed that motivation has a significant impact on English as a foreign language learners’ language achievement. It is also believed that it is mostly the teacher who can determine the level of success or failure in achieving the determined sets of goals in the educational process. Studies of motivation in language learning have mainly focused on different types of intrinsic and extrinsic motivations. However, only a few studies addressed the impact of teacher training workshops on teachers’ perceptions of the importance and practices of motivational strategies in Iranian EFL classes. To do so, 200 high school English language teachers were selected through convenience sampling. A quasi-experimental research design consisting of pretest, treatment, and posttest was used. The teachers received the Teachers' Motivational Strategies Scale (TMSS). The questionnaire consisted of 37 micro-strategies and 6 macro-strategies. Then, 100 teachers were invited to take part in an in-service training workshop on the importance and types of macro and micro-motivational strategies, but 100 were not included in the treatment. The control and experimental groups’ scores on all micro and macro motivational strategies were submitted to different independent samples-t-tests. Results revealed that the experimental group’s scores on all micro and macro strategies exceeded the control group’s mean scores, verifying the effectiveness of teacher training workshops on teachers’ cognitions and practices of motivational strategies in EFL classrooms.
Effect of Booroola fecundity (FeCB) gene on litter size and scope for exploitation of Nilagiri synthetic sheep
Authors: Chaudhari Arth Bhaljibhai , Ramanujam Rajendran , Ragothaman Venkataramanan 
Published: July 2023

Abstract
Background
The Nilagiri Synthetic was evolved at the Sheep Breeding Research Station, Sandynallah, The Nilgiris, by crossing Nilagiri with Merino and Rambouillet sheep in the year 1986 and performances evaluated by Iyue in the year 1993. Nilagiri Synthetic sheep are maintained for mutton and fine wool production. The presence of FecB mutation, which increases fecundity, has been confirmed recently in Nilagiri Synthetic breed.
Methods
To find out the scope for utilizing this mutation in the breeding programme to exploit the population, evaluation of effect of this mutation on litter traits was carried out. Litter sizes were compared between non-carrier wild type (++) and carrier (B+) ewes.
Result
The litter size at birth was 1.09 ± 0.10 and 1.60 ± 0.10, respectively. The litter size at weaning was 1.09 ± 0.11 and 1.56 ± 0.12, respectively. The litter size at birth, litter size at weaning and lifetime traits of litter size were higher among carrier animals. These results indicate scope for utilising the FecB mutation to improve prolificacy in the Nilagiri Synthetic breed.
The epidemiology of notifiable diseases in Australia and the impact of the COVID-19 pandemic, 2012-2022
Authors: Sohail Asma , Cheng Allen C , McGuinness Sarah L , Leder Karin 
Published: July 2023

Abstract
Background
Infectious disease surveillance tracks disease epidemiology and informs prevention and control. Public health measures implemented in Australia during the COVID-19 pandemic (2020 to 2022) affected infectious disease epidemiology. We examined notifiable disease epidemiology in Australia from 2012 to 2022, evaluating disease trends and pandemic impacts.
Methods
We analysed case notifications supplied to the Australian National Notifiable Disease Surveillance System (NNDSS) from 1 January 2012 to 30 June 2022.
Results
Over the study period, there were 10,918,095 notifications of 68 diseases. Average notification incidence increased by 10% per year. Respiratory diseases were the most commonly notified disease group (79% of all notifications) and vector-borne diseases (VBD) the least (< 1%). The ten highest-incidence diseases comprised 97% of all notifications over the study period, with COVID-19 alone accounting for 66%. Notifications were most common among the 20-39-year age group (38%). From 2012–2019, notification incidence of gastrointestinal, respiratory and sexually transmissible infections (STI) increased, whereas for bloodborne viral hepatitis (BBVH), VBDs and imported diseases it decreased. From 2020–2021, average notification incidence of most non-COVID-19 respiratory diseases decreased compared to the 2012–2019 period; STI notification incidence remained fairly stable; notification incidence of some gastrointestinal diseases increased while others decreased; and notification of imported diseases markedly decreased. A rebound in notification incidence was seen for some diseases in the first six months of 2022.
Conclusion
Prior to the COVID-19 pandemic, most notifiable diseases had increasing notification incidence, except for BBVH, VBDs and imported diseases. COVID-19-related public health measures had variable impacts on notifiable diseases.
Endogenous Horizontal and Vertical Differentiation: Measuring Value Added in Intra-industry Trade
Authors: Dutta Sourish 
Published: July 2023

Abstract
Studying intra-industry trade involves theoretical explanations and empirical methods to measure the phenomenon. Indicators have been developed to measure the intensity of intra-industry trade, leading to theoretical models explaining its determinants. It is essential to distinguish between horizontal and vertical differentiation in empirical analyses. The determinants and consequences of intra-industry trade depend on whether the traded products differ in quality. A method for distinguishing between vertical and horizontal differentiation involves comparing exports' unit value to imports for each industry's intra-industry trade. This approach has limitations, leading to the need for an alternative method.
Predictors of Initial CPAP Prescription and Subsequent Course with CPAP in Patients with Central Sleep Apneas
Authors: Locke Brian W. , Sellman Jeffrey , McFarland Jonathan , Uribe Francisco , Workman Kimberly , Sundar Krishna M. 
Published: July 2023

Abstract
Purpose: Guidelines recommend considering an initial trial of continuous positive airway pressure (CPAP) to treat central sleep apnea (CSA). However, practice patterns vary widely. This study investigated predictors for an initial trial of CPAP in patients with central apneas
and whether those factors predict adequate treatment response in patients receiving an initial CPAP trial.
Methods: Charts of patients receiving a diagnostic code for CSA following a sleep study during 2016-2018 at a single center were reviewed. Patient factors, initial treatment prescriptions, and subsequent changes to therapy were extracted from electronic health records. Regression models were used to estimate factors associated with an initial CPAP prescription and the likelihood of an adequate CPAP response (no subsequent therapy change or nonadherence) among patients prescribed CPAP.
Results: 429/588 (73%) patients with central apneas received an initial trial of CPAP. Younger age, diagnosis by home sleep testing, non-opiate etiology of central apneas, and a lower proportion of central apneas at diagnosis were independently associated with a higher likelihood of an initial CPAP trial. A lower proportion of central apneas was associated with a higher probability of adequate response, while current smoking and opiate-related central apneas predicted an unsuccessful CPAP trial. A new finding was that older age predicted a lower likelihood of an initial CPAP prescription but did not predict a suboptimal response to CPAP.
Conclusion: Clinicians may incorrectly weigh certain clinical and sleep study characteristics when deciding whether to trial CPAP for patients with central apneas.