bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term field study of lispro and neutral protamine Hagedorn insulins treatment in dogs with diabetes mellitus
Authors: Kuzi Sharon , Mazaki‐Tovi Michal , Hershkovitz Shai , Yas Einat , Hess Rebecka S. 
Published: February 2023

AbstractBackgroundThe long‐term clinical and biofhemical effects of basal‐bolus insulin treatment with lispro and NPH in dogs with diabetes mellitus are undocumented.ObjectivesTo perform a prospective pilot field study of the long‐term effects of lispro and NPH on clinical signs and serum fructosamine concentrations (SFC) in dogs with diabetes mellitus.MethodsTwelve dogs received combined lispro and NPH insulins treatment twice a day and were examined every 2 weeks for 2 months (visits 1–4), and every 4 weeks for up to 4 additional months (visits 5–8). Clinical signs and SFC were recorded at each visit. Polyuria and polydipsia (PU/PD) were scored as absent (0) or present (1).ResultsMedian (range) PU/PD scores of combined visits 5–8 (0, 0–1) were significantly lower than median scores of combined visits 1–4 (1, 0–1, p = 0.03) and at enrolment (1, 0–1, p = 0.045). Median (range) SFC of combined visits 5–8 (512 mmol/L, 401–974 mmol/L) was significantly lower than SFC of combined visits 1–4 (578 mmol/L, 302–996 mmol/L, p = 0.002) and at enrolment (662 mmol/L, 450–990 mmol/L, p = 0.03). Lispro insulin dose was significantly and negatively, albeit weakly, correlated with SFC concentration during visits 1 through 8 (r = –0.3, p = 0.013). Median duration of follow up was 6 months (range 0.5–6) and most dogs (8, 66.7%) were followed for 6 months. Four dogs withdrew from the study within 0.5–5 months because of documented or suspected hypoglycaemia, short NPH duration or sudden unexplained death. Hypoglycaemia was noted in 6 dogs.ConclusionsLong‐term lispro and NPH combination therapy may improve clinical and biochemical control of some diabetic dogs with comorbidities. Risk of hypoglycaemia should be addressed with close monitoring.
Clinical characteristics and long-term management of prepubertal testicular teratomas: a retrospective, multicenter study
Authors: Zhou Guanglun , Sun Fenglan , Yu Xin , Huang Ruifeng , Liu Xiaodong , Ouyang Yaoling , Yang Zhilin , Li Shoulin 
Published: February 2023

AbstractPrepubertal testicular teratomas are rare tumors with limited practical guidance for their management. This study aimed to analyze a large multicenter database to establish the optimal management of testicular teratomas. We retrospectively collected data on testicular teratomas in children younger than 12 years who underwent surgery without postoperative chemotherapy in three large professional children’s institutions in China between 2007 and 2021. The biological behavior and long-term outcomes of testicular teratomas were analyzed. In total, 487 children (with 393 mature teratomas and 94 immature teratomas) were included. Among mature teratomas, 375 cases were testis-sparing, 18 were orchiectomies, 346 were operated through the scrotal approach, and 47 underwent the inguinal approach. The median follow-up period was 70 months, and no recurrence or testicular atrophy was observed. Among the children with immature teratomas, 54 underwent testis-sparing surgery, 40 underwent orchiectomy, 43 were operated through the scrotal approach, and 51 were operated through the inguinal approach. Two cases of immature teratomas with cryptorchidism had local recurrence or metastasis within 1 year of the operation. The median follow-up duration was 76 months. No other patients had recurrence, metastasis, or testicular atrophy. Conclusion: Testicular-sparing surgery is the first treatment choice for prepubertal testicular teratomas, with the scrotal approach being a safe and well-tolerated strategy for these diseases. Additionally, patients with immature teratomas and cryptorchidism may have tumor recurrence or metastasis after surgery. Therefore, these patients should be closely followed up in the first year after surgery.

What is Known:• There is a fundamental difference between testicular tumours in childhood and those in adulthood - not only in terms of the difference and incidence but also in terms of histology.• For surgical techniques, the inguinal approach is recommended for the treatment of testicular teratomas in children.

What is New:• The scrotal approach being a safe and well-tolerated strategy for testicular teratomas in children.• Patients with immature teratomas and cryptorchidism may have tumor recurrence or metastasis after surgery. These patients should be closely followed up in the first year after surgery.
Structural characterization of cuboidal α-Fe2O3 nanoparticles synthesized by a facile approach
Authors: Sridevi H. , Bhat M. Ramananda , Kumar P. Senthil , Kumar N. Manoj , Selvaraj Raja 
Published: February 2023

Abstractα-Fe2O3 nanoparticles were synthesized using Tabebuia aurea leaf extract by a facile approach. The signature peaks for Fe and O in the EDX spectrum verified the formation of Fe2O3 nanoparticles. Cuboidal-shaped nanoparticles were observed in the FE-SEM image. In the XRD pattern, it was observed that the peaks belong to α-Fe2O3 nanoparticles. These particles were pure and crystalline with an average particle size of 25.69 nm. The signals at 538 and 494 cm−1 in the FTIR image confirmed the formation of hematite nanoparticles. BET analysis showed a comparatively greater surface area (31.03 m2/g) than the commercial α-Fe2O3 nanoparticles, and the pores were mesoporous. XPS analysis confirmed the existence of α-Fe2O3 by showing the specific oxidation states for iron and oxygen at 710.34 and 529.67 eV, respectively. The saturation magnetization value of 13.97 emu/g confirmed the superparamagnetic nature. The TGA, which determined the thermal stability of the nanoparticles, reported a total weight loss of 12.75%. Hence, the highly crystalline, pure, mesoporous, superparamagnetic α-Fe2O3 nanoparticles with high surface area synthesized using T. aurea leaf extract can be potentially applied in diverse fields.
Simultaneous model-based inversion of pre-stack 3D seismic data targeting a deep geothermal reservoir, Northwest Hungary
Authors: Masri Emad N. , Takács Ernő 
Published: February 2023

AbstractThe well-known, traditional way to extend P-wave acoustic impedance data between and beyond the well log locations is the post-stack inversion of seismic data usually available in the surroundings of the boreholes. A relatively new trend in the seismic exploration is based on the pre-stack inversion of the seismic CDP gathers providing both the P- and S-wave acoustic impedance sections (and volumes), as well as the estimated density data. This methodology is often called as simultaneous model-based inversion and can be utilized not only for hydrocarbon exploration, but it might also be a useful tool for the investigation of geothermal resources. In this study, we will compare the results of post-stack and pre-stack acoustic impedance inversions utilizing the same seismic volume. We will demonstrate and analyze the inverted attribute sections (and some of their derivatives) obtained by the pre-stack algorithm in detail. Finally, we will draw the conclusions about the lithological discrimination of the studied complex carbonate geothermal reservoir located in the pre-Cenozoic basement of the Little Hungarian Plain.
Recent Advances in Nano-Enabled Seed Treatment Strategies for Sustainable Agriculture: Challenges, Risk Assessment, and Future Perspectives
Authors: Shelar Amruta , Nile Shivraj Hariram , Singh Ajay Vikram , Rothenstein Dirk , Bill Joachim , Xiao Jianbo , Chaskar Manohar , Kai Guoyin , Patil Rajendra 
Published: February 2023

AbstractAgro seeds are vulnerable to environmental stressors, adversely affecting seed vigor, crop growth, and crop productivity. Different agrochemical-based seed treatments enhance seed germination, but they can also cause damage to the environment; therefore, sustainable technologies such as nano-based agrochemicals are urgently needed. Nanoagrochemicals can reduce the dose-dependent toxicity of seed treatment, thereby improving seed viability and ensuring the controlled release of nanoagrochemical active ingredients However, the applications of nanoagrochemicals to plants in the field raise concerns about nanomaterial safety, exposure levels, and toxicological implications to the environment and human health. In the present comprehensive review, the development, scope, challenges, and risk assessments of nanoagrochemicals on seed treatment are discussed. Moreover, the implementation obstacles for nanoagrochemicals use in seed treatments, their commercialization potential, and the need for policy regulations to assess possible risks are also discussed. Based on our knowledge, this is the first time that we have presented legendary literature to readers in order to help them gain a deeper understanding of upcoming nanotechnologies that may enable the development of future generation seed treatment agrochemical formulations, their scope, and potential risks associated with seed treatment.
FPGA Design Deobfuscation by Iterative LUT Modification at Bitstream Level
Authors: Moraitis Michail , Dubrova Elena 
Published: February 2023

AbstractHardware obfuscation is a well-known countermeasure against reverse engineering. For FPGA designs, obfuscation can be implemented with a small overhead by using underutilised logic cells; however, its effectiveness depends on the stealthiness of the added redundancy. In this paper, we show that it is possible to deobfuscate an SRAM FPGA design by ensuring the full controllability of each instantiated look-up table input via iterative bitstream modification. The presented algorithm works directly on bitstream and does not require the possession of a flattened netlist. The feasibility of our approach is verified on the example of an obfuscated SNOW 3G design implemented on a Xilinx 7-series FPGA.
How quality of work-life influence employee job satisfaction in a gas processing plant in Ghana
Authors: Hammond Mavis , Owusu Nicodemus Osei , Nunoo Edward Kweku , Boampong Georgina , Osman Aminu , Panin Anthony , Nyametso Johnie Kodjoe , Essen Bernice 
Published: February 2023

AbstractThe influence of quality of work-life on job satisfaction is critical for sustaining high-level skilled workers and enhancing productivity in the oil and gas industry. This study examined the influence of quality of work-life on job satisfaction among workers in a gas processing plant. A descriptive analytical design and a census approach were used to assess 200 staff. The analysis established a positive relationship between employee job satisfaction and the four constructs of quality of work life; safe working environments, Work-life balance, personal development, and emotional well-being at significant levels. With the latter construct registering the highest correlation with job satisfaction, the study recommends the management of a functional early guidance support system for workers who may exhibit early symptoms of emotional well-being distress. It is imperative for management to consolidate and significantly improve on established measures for employees to maximise both work output and avoid work-family conflicts. Management should maintain robust safety protocols and an emergency response unit to ensure employees work in a relaxed environment that promotes workplace well-being. These are envisaged to sustain employee workplace assistance programs that can confidently discuss and address workers' stress, anxiety, and other related concerns at the workplace.
Can acute care surgery sustain as a specialty in Singapore?
Authors: Tian Brian WCA 
Published: February 2023

AbstractAcute care surgery [ACS] is a natural evolution of trauma as a specialty. Globally, there have been positive results seen. In Singapore, ACS is a new specialty that is trying to establish itself. Early results appear promising—reduced length of stay, faster times to operation. Although ACS has had a positive impact on workflow, it’s sustainability as a specialty faces many challenges ahead. This paper describes how ACS is run in Singapore General Hospital and the challenges it must overcome to be sustainable service.
Post-compression of high-energy, sub-picosecond laser pulses
Authors: Bleotu P.-G. , Wheeler J. , Mironov S. Yu. , Ginzburg V. , Masruri M. , Naziru A. , Secareanu R. , Ursescu D. , Perez F. , De Sousa J. , Badarau D. , Veuillot E. , Audebert P. , Khazanov E. , Mourou G. 
Published: February 2023

Abstract
The post-compression technique based on self-phase modulation of high-energy pulses leads to an increase in achievable peak power and intensity. Typically, the pulses considered in experiments have been less than 100 fs in duration. Here, the method is applied to the ELFIE laser system at the LULI facility, for a pulse of 7 J energy and an initial measured duration of 350 fs. A 5-mm-thick fused silica window and a 2 mm cyclic-olefin polymer were used as optical nonlinear materials. The 9 cm diameter beam was spectrally broadened to a bandwidth corresponding to 124 fs Fourier-limited pulse duration, and then it was partly post-compressed to 200 fs. After measuring the spatial spectra of the beam fluence, a uniform gain factor of 4 increase in the fluctuations over the studied range of frequencies is observed, due to small-scale self-focusing.
Deterrence effect of penalties upon adolescent cannabis use
Authors: Smyth Bobby P. , Davey Aoife , Keenan Eamon 
Published: February 2023

AbstractObjective:Penalties are used in an effort to curtail drug use by citizens in most societies. There are growing calls for a reduction or elimination of such penalties. Deterrence theory suggests that use should increase if penalties reduce and vice versa. We sought to examine the relationship between changes to penalties for drug possession and adolescent cannabis use.Method:Ten instances of penalty change occurred in Europe between 2000 and 2014, seven of which involved penalty reduction and three involved penalty increase. We conducted a secondary analysis of a series of cross-sectional surveys of 15–16-year-old school children, the ESPAD surveys, which are conducted every four years. We focused on past month cannabis use. We anticipated that an eight-year time span before and after each penalty change would yield two data points either side of the change. A simple trend line was fitted to the data points for each country.Results:In eight cases, the trend slope in past month cannabis use was in the direction predicted by deterrence theory, the two exceptions being the UK policy changes. Using the principals of binomial distributions, the likelihood of this happening by chance is 56/1024 = 0.05. The median change in the baseline prevalence rate was by 21%.Conclusions:The science seems far from settled on this issue. There remains a distinct possibility that reducing penalties could contribute to small increases in adolescent cannabis use and consequently increase cannabis-related harms. This possibility should be considered in any political decision-making influencing drug policy changes.
Spatial and temporal dynamics of cropland in the Sanjiang Plain from 2014 to 2020 based on annual 30 m crop data layers
Authors: Jin Cui , Zhang Zeyu , Cai Hongyan , Cao Ge , Li Xintao , Li Xueming 
Published: February 2023

AbstractThe land cover of the Sanjiang Plain has changed dramatically since the 1950s. Although previous studies have analysed its spatiotemporal dynamics at long time intervals, a near real-time and accurate representation of the interannual evolution of cropping patterns in this region is of far-reaching importance for rationally allocating agricultural resources and ensuring food security. Based on the 30 m and 10 m land cover datasets in 2015 and 2017–2019, the current study used Landsat-8 satellite data in 2014, 2016 and 2020 to identify paddy rice and dryland crops using a decision tree classification approach and constructed the annual cropland datasets of the Sanjiang Plain from 2014 to 2020. The results show that the overall classification accuracies of crop datasets exceeded 95%, and the Kappa coefficients were higher than 0.92. The average annual accuracies of users and producers were 93% and 94% for rice fields and 97% and 95% for dryland crops, respectively. During the 7 years, the total area of paddy fields and dryland crops decreased by 5% and 8%. However, with minor positive and negative variation between years. 24.2% of paddy rice and 42% of dryland crops has been cultivated under 4 years. The centres of gravity for both crops mainly aggregated in the central counties with the migration direction and magnitude varying interannually. The current study emphasizes the importance of establishing annual high-resolution crop datasets to track the detailed spatio-temporal trajectories of cropping patterns that are essential to support sustainable cropland management and agricultural development.
Video head impulse test for the assessment of vestibular function in patients with idiopathic sudden sensorineural hearing loss without vertigo
Authors: Battat N , Ungar O J , Handzel O , Eta R Abu , Oron Y 
Published: February 2023

AbstractObjectiveIdiopathic sudden sensorineural hearing loss may be accompanied by dizziness without true vertigo. This study used the video head impulse test to evaluate vestibular function in idiopathic sudden sensorineural hearing loss patients who described experiencing dizziness and not true vertigo.MethodsA prospective study was conducted of 30 consecutive patients diagnosed with idiopathic sudden sensorineural hearing loss with dizziness without true vertigo. A comparison of the video head impulse test results of the patients who complained of dizziness (symptomatic group) with a group of patients with idiopathic sudden sensorineural hearing loss and no dizziness (asymptomatic) was performed.ResultsNine patients (30 per cent) were symptomatic. Two of those patients had abnormal video head impulse test findings. Seven patients in the asymptomatic group (7 out of 21, 33 per cent) presented with abnormal video head impulse test results. No significant difference in vestibular function between the two groups was detected by the video head impulse test.ConclusionThe site of insult in patients with idiopathic sudden sensorineural hearing loss without true vertigo is usually limited to the cochlea or the cochlear nerve.
Human papillomavirus related oropharyngeal cancer: identifying and quantifying topics of patient interest
Authors: Fritz C , Barrette L-X , Prasad A , Triantafillou V , Suresh N , De Ravin E , Rajasekaran K 
Published: February 2023

AbstractObjectiveAs the incidence of human papillomavirus related oropharyngeal cancer continues to rise, it is increasingly important for public understanding to keep pace. This study aimed to identify areas of patient interest and concern regarding human papillomavirus and oropharyngeal cancer.MethodThis study was a retrospective survey of search queries containing the keywords ‘HPV cancer’ between September 2015 and March 2021.ResultsThere was 3.5-fold more interest in human papillomavirus related oropharyngeal cancer (15 800 searches per month) compared with human papillomavirus related cervical cancer (4500 searches per month). Among searches referencing cancer appearance, 96.8 per cent pertained to the head and neck region (3050 searches per month). Among vaccination searches, 16 of 47 (34.0 per cent; 600 searches per month) referenced human papillomavirus vaccines as being a cause of cancer rather than preventing cancer.ConclusionThe vast majority of online searches into human papillomavirus cancer pertain to the oropharynx. There are relatively few search queries on the topic of vaccination preventing human papillomavirus associated oropharyngeal cancer, which highlights the continued importance of patient education and awareness campaigns.
Spatial distribution of preantral follicles in ovarian parenchyma of bovine species
Authors: González Suellen Miguez , Cerezetti Marcela Bortoletto , Bergamo Larissa Zamparone , Morotti Fábio , Seneda Marcelo Marcondes 
Published: February 2023

SummaryThe goal of this study was to determine the distribution of preantral follicles in bovine ovaries. Follicular distribution in the ovaries (n = 12) was evaluated in the region of the greater curvature of the ovary (GCO) and the region close to the ovarian pedicle (OP) of Bos taurus indicus heifers of the Nelore breed. Two fragments were obtained from each region of the ovary (GCO and OP). The mean weight of the ovaries was 4.04 ± 0.32 g. The mean antral follicle count (AFC) was 54.58 ± 3.55 follicles (minimum and maximum variation of 30 and 71 follicles, respectively). In total, 1123 follicles were visualized in the region of the GCO; 949 (84.5%) of them were primordial follicles and 174 (15.5%) were developing follicles. The region close to the OP contained 1454 follicles, of which 1266 (87%) were primordial follicles and 44 (12.9%) were developing follicles. The OP region showed a higher proportion of intact follicles in the primordial (P < 0.0001) and primary (P = 0.042) stages compared with the GCO region. The proportion of secondary follicles was similar in the OP and GCO regions. The ovaries of two bovine females (16%; 2/12) contained multi-oocytes follicles, which were characterized as primary follicles. Therefore, the distribution of preantral follicles in the bovine ovary was heterogeneous, with the region close to the OP containing a greater number of preantral follicles compared with the GCO region (P < 0.05).
High‐Pressure Mechanical Properties of Talc: Implications for Fault Strength and Slip Processes
Authors: Boneh Y. , Pec M. , Hirth G. 
Published: February 2023

AbstractThe hydrous mineral talc is stable over a relatively large P‐T field and can form due to fluid migration and metamorphic reactions in mafic and ultramafic rocks and in faults along plate boundary interfaces. Talc is known to be one of the weakest minerals, making it potentially important for the deformation dynamics and seismic characteristics of faults. However, little is known about talc's mechanical properties at high temperatures under confining pressures greater than 0.5 GPa. We present results of deformation experiments on natural talc cylinders exploring talc rheology under 0.5–1.5 GPa and 400–700°C, P‐T conditions simulating conditions at deep faults and subducted slab interface. At these pressures, the strength of talc is highly temperature‐dependent where the thermal weakening is associated with an increased tendency for localization. The strength of talc and friction coefficient inferred from Mohr circle analysis is between 0.13 at 400°C to ∼0.01 at 700°C. Strength comparison with other phyllosilicates highlights talc as the weakest mineral, a factor of ∼3–4 weaker than antigorite and a factor of ∼2 weaker than chlorite. The observed friction coefficients for talc are consistent with those inferred for subducted slabs and the San Andreas fault. We conclude that the presence of talc may explain the low strength of faults and of subducted slab interface at depths where transient slow slip events occur.