bluuebunny/crossref_metadata_2025_split huggingface dataset:
La survie après fracture ostéoporotique de l’extrémité supérieure du fémur
Authors: Zrour Saoussen , Belhaj Salem Siwar , Ben Chekaya Narimane , Grassa Rim , Bejia Ismail , Abid Abderazek 
Published: January 2025

Objectifs : Evaluer la survie et ses facteurs associés après fracture ostéoporotique du fémur proximal.
Méthodes : Etude rétrospective de 81 patients, hospitalisés durant 2020 au CHU Monastir. La courbe de Kaplan-Meier a été utilisée pour l’analyse de la survie.
Résultats : L’âge moyen était 77,46 ± 17,36 ans et la fracture du col de fémur représentait 54% des cas. La survie globale était de 84,6 % à 6 mois, 75,4 % à 1 an et 63,4 % à 2 ans. La médiane de survie était 30 mois. Les patients âgés de plus de 75 ans avaient une survie plus courte (68% à un an versus 83% et 55% versus 72% à 2 ans ; p < 10-3).
Le taux de survie à 1 an était à 83,3 % chez
les patients âgés de moins de 75 ans et 68,6 % chez les sujets de plus de 75 ans. A
2 ans après la chirurgie, 72,5 % des patients âgés de moins de 75 ans et 55,5 % des
patients de plus de 75 ans étaient encore vivants.
Le taux de survie à 1 an était à 83,3 % chez
les patients âgés de moins de 75 ans et 68,6 % chez les sujets de plus de 75 ans. A
2 ans après la chirurgie, 72,5 % des patients âgés de moins de 75 ans et 55,5 % des
patients de plus de 75 ans étaient encore vivants.
Conclusion : La morbi-mortalité est lourde après fracture ostéoporotique du fémur proximal
Pengaruh Kualitas Pelayanan Dan Brand Image Terhadap Loyalitas Merek Dengan Keputusan Pembelian Sebagai Variabel Moderasi Pada Spx Exspress Elfan E
Authors: Dayu kristianto  , Eko Handayanto  , Yulist Rima Fiandari  
Published: January 2025

Tujuan dari penelitian ini adalah untuk mengetahui apakah loyalitas merek di SPX Express Elfan E dipengaruhi oleh kualitas layanan dan citra merek, dan apakah tindakan pembelian dapat mengurangi dampak faktor-faktor tersebut terhadap loyalitas merek. Dengan menggunakan metodologi dengan 133 responden, penelitian ini merupakan bentuk penelitian kuantitatif. Di sisi lain, survei atau kuesioner digunakan dalam metode pengumpulan data. Setelah itu, analisis statistik digunakan untuk memahami data dan membuat kesimpulan dari hasil. Berdasarkan hasil penelitian, loyalitas merek di SPX Express Elfan E dipengaruhi oleh kualitas layanan dan citra merek, dengan nilai signifikansi masing-masing sebesar 0,040 dan 0,000. Dengan nilai signifikansi sebesar 0,248, keputusan pembelian di SPX Express Elfan E tidak dapat memoderasi loyalitas merek dan keunggulan layanan. Di SPX Express Elfan E, loyalitas merek dipengaruhi secara signifikan oleh keputusan pembelian, sebagaimana ditunjukkan oleh nilai signifikansi sebesar 0,001.
Combining the (In)compatible: Ukrainian Strategies for Living with Competing Religious, Feminist, and/or LGBT+ Identities
Authors: Basauri Ziuzina Anna Mariya 
Published: January 2025

The article is devoted to strategies for living with multiple competing identities, based on the study Combining the (In)Compatible, which was conducted by WASR in 2021–2022 to explore the experience of feminist and LGBTQ+ believers in Ukraine. 40 interviews were conducted with people of different age, education, and religious affiliation. From their responses we have identified 3 main strategies of coping with the stress from having competing multiple identities: 1) transformation of one identity from a public identity into a private one (e.g. when people stop participating in their religious community, but focus on personal religiosity instead, or when they stop expressing their feminist identity in their religious communities); 2) renunciation of one of the identities (e.g. when people completely withdraw from their original religious community without looking for a substitute); 3) combination of both identities in public, which can lead to two opposite results: being accepted in both competing communities and leading a fruitful life, or being rejected by both communities, exacerbating the stress of juggling competing identities.
Association of Social Isolation With Hospitalization and Nursing Home Entry Among Community-Dwelling Older Adults
Authors: Pomeroy Mary Louise , Cudjoe Thomas K. M. , Cuellar Alison E. , Ihara Emily S. , Ornstein Katherine A. , Bollens-Lund Evan , Kotwal Ashwin A. , Gimm Gilbert W. 
Published: July 2023

ImportanceSocial isolation is associated with adverse health outcomes, yet its implications for hospitalization and nursing home entry are not well understood.ObjectiveTo evaluate whether higher levels of social isolation are associated with overnight hospitalization, skilled nursing facility stays, and nursing home placement among a nationally representative sample of community-dwelling older adults after adjusting for key health and social characteristics, including loneliness and depressive symptoms.Design, Setting, and ParticipantsThis observational cohort study included 7 waves of longitudinal panel data from the Health and Retirement Study, with community-dwelling adults aged 65 years or older interviewed between March 1, 2006, and June 30, 2018 (11 517 respondents; 21 294 person-years). Data were analyzed from May 25, 2022, to May 4, 2023.Main Outcomes and MeasuresSocial isolation was measured with a multidomain 6-item scale (range, 0-6, in which a higher score indicates greater isolation). Multivariate logistic regressions were performed on survey-weighted data to produce national estimates for the odds of self-reported hospitalization, skilled nursing facility stays, and nursing home placement over time.ResultsA total of 57% of this study’s 11 517 participants were female, 43% were male, 8.4% were Black, 6.7% were Hispanic or Latino, 88.1% were White, 3.5% were other (“other” includes American Indian or Alaska Native, Asian or Pacific Islander, and other race, which has no further breakdown available because this variable was obtained directly from the Health and Retirement Study), and 58.2% were aged 65 to 74 years. Approximately 15% of community-dwelling older adults in the US experienced social isolation. Higher social isolation scores were significantly associated with increased odds of nursing home placement (odds ratio, 2.01; 95% CI, 1.21-3.32) and skilled nursing facility stays (odds ratio, 1.16; 95% CI, 1.06-1.28) during 2 years. With each point increase in an individual’s social isolation score, the estimated probability of nursing home placement or a skilled nursing facility stay increased by 0.5 and 0.4 percentage points, respectively, during 2 years. Higher levels of social isolation were not associated with 2-year hospitalization rates.Conclusions and RelevanceThis cohort study found that social isolation was a significant risk factor for nursing home use among older adults. Efforts to deter or delay nursing home entry should seek to enhance social contact at home or in community settings. The design and assessment of interventions that optimize the social connections of older adults have the potential to improve their health trajectories and outcomes.
Consumption of Soft Drinks and Overweight and Obesity Among Adolescents in 107 Countries and Regions
Authors: Hu Huan , Song Jing , MacGregor Graham A. , He Feng J. 
Published: July 2023

ImportanceSoft drink consumption is associated with weight gain in children and adolescents, but little is known about the association between soft drink consumption and prevalence of the overweight and obesity in adolescents.ObjectiveTo investigate the association of soft drink consumption with overweight and obesity in adolescents enrolled in school (hereafter, school-going adolescents) using country-level and individual-level data.Design, Setting, and ParticipantsThis cross-sectional study used data from 3 cross-sectional studies including 107 countries and regions that participated in the Global School-Based Student Health Survey (2009-2017), the European Health Behavior in School-Aged Children study (2017-2018), and the US Youth Risk Behavior Survey (2019).ExposureDaily soft drink consumption (consuming soft drinks 1 or more times per day or not).Main Outcome and MeasureOverweight and obesity defined by the World Health Organization Growth Reference Data.ResultsAmong the 107 countries and regions, 65 were low- and middle-income, and 42 were high-income countries and regions, with a total of 405 528 school-going adolescents (mean [SD] age, 14.2 [1.7] years; 196 147 [48.4%] males). The prevalence of overweight and obesity among adolescent students varied from 3.3% (95% CI, 2.6 to 4.1) in Cambodia to 64.0% (95% CI, 57.0 to 71.6) in Niue, and the prevalence of adolescent students consuming soft drinks 1 or more times per day varied from 3.3% (95% CI, 2.9 to 3.7) in Iceland to 79.6% (95% CI, 74.0 to 85.3) in Niue. There was a positive correlation between the prevalence of daily soft drink consumption and the prevalence of overweight and obesity (R, 0.44; P &amp;lt; .001). The pooled analysis using individual-level data also showed a statistically significant association between daily soft drink consumption and overweight and obesity (daily soft drink consumption vs nondaily soft drink consumption), with an odds ratio of 1.14 (95% CI, 1.08 to 1.21) among school-going adolescents.Conclusions and RelevanceIn this study of 107 countries and regions, the prevalence of daily consumption of soft drinks was associated with the prevalence of overweight and obesity among adolescent students. Our results, in conjunction with other evidence, suggest that reducing soft drink consumption should be a priority in combating adolescent overweight and obesity.
Comparative Effectiveness of Anticoagulants in Patients With Cancer-Associated Thrombosis
Authors: Riaz Irbaz Bin , Fuentes Harry , Deng Yihong , Naqvi Syed Arsalan Ahmed , Yao Xiaoxi , Sangaralingham Lindsey R. , Houghton Damon E. , Padrnos Leslie J. , Shamoun Fadi E. , Wysokinski Waldemar E. , McBane Robert D. 
Published: July 2023

ImportancePatterns of clinical utilization and comparative effectiveness of anticoagulants for cancer-associated thrombosis (CAT) remain largely unexplored.ObjectivesTo assess patterns of and factors associated with anticoagulant use and to evaluate the comparative effectiveness of contemporary anticoagulants in patients with active cancer in a clinical setting.Design, Setting, and ParticipantsThis retrospective cohort study obtained deidentified OptumLabs electronic health record claims data from January 1, 2012, to September 30, 2019. Adult patients (≥18 years of age) with a primary cancer diagnosis (except skin cancer) during at least 1 inpatient or 2 outpatient visits within 6 months before the venous thromboembolism (VTE) date were included. Data were analyzed from April 2020 to September 2021.ExposuresThe patients were grouped according to the anticoagulant prescribed: (1) direct oral anticoagulants (DOACs), (2) low-molecular-weight heparin (LMWH), and (3) warfarin.Main Outcomes and MeasuresOdds ratios (ORs) were used to present the association between factors of interest and utilization of anticoagulants. Main efficacy outcomes included risk of VTE recurrence and all-cause mortality. Main safety outcomes included the risk of hospitalization due to major bleeding. Relative treatment effect estimates were expressed as hazard ratios (HRs) with 95% CIs.ResultsThis study included 5100 patients (mean [SD] age, 66.3 [12.3] years; 2670 [52.4%] women; 799 [15.7%] Black, 389 [7.6%] Hispanic, and 3559 [69.8%] White individuals). Overall, 2512 (49.3%), 1488 (29.2%), and 1460 (28.6%) filled prescriptions for DOACs, LMWH, and warfarin, respectively. The median (IQR) treatment duration was 3.2 (1.0-6.5) months for DOACs, 3.1 (1.0-6.8) months for warfarin, and 1.8 (0.9-3.8) months for LWMH. Patients with lung (OR, 2.07; 95% CI, 1.12-3.65), urological (OR, 1.94; 95% CI,1.08-3.49), gynecological (OR, 4.25; 95% CI, 2.31-7.82), and colorectal (OR, 2.26; 95% CI, 1.20-4.32) cancer were associated with increased prescriptions for LMWH compared with DOACs. LMWH (HR, 1.47; 95% CI, 1.14-1.90) and warfarin (HR, 1.46; 95% CI, 1.13-1.87) were associated with an increased risk of VTE recurrences compared with DOACs. LMWH was associated with an increased risk of major bleeding (HR, 2.27; 95% CI, 1.62-3.20) and higher all-cause mortality (HR, 1.61; 95% CI, 1.15-2.25) compared with DOACs.Conclusions and RelevanceIn this comparative effectiveness study of claims-based data, patients with CAT received anticoagulation for a remarkably short duration in clinical settings. DOACs was associated with a lower risk of VTE recurrence, major bleeding, and mortality. Warfarin may still be considered for patients with contraindications to DOACs and those with poor persistence on LMWH.
Power of Representation in Educational Materials: Teaching Cutaneous Lupus Across Skin Tones in an Interactive Module
Authors: Tinianow Alex , Sous Dana , Abreu Damien , Scharff Trisha B. , Thomashow Michael , Bayliss Susan , Goglin Sarah , Monroe Joe R. , Mwanthi Muithi , Jones Heather A. , Zickuhr Lisa 
Published: July 2023

ObjectiveClinicians report low confidence assessing cutaneous lupus erythematosus (CLE) lesions, especially for patients who identify as Black, Indigenous, and People of Color (BIPOC) who are historically excluded from educational materials. To address this, we created an online, interactive module teaching an approach to assessing CLE across skin tones and measured its impact on medical knowledge and confidence.MethodsOur team created a module with case‐based methods to introduce an approach to CLE, common mimicking rashes, and tips for photographing cutaneous lesions in BIPOC. Graduate medical trainees from five academic institutions completed the module. Using surveys and pre–post testing, we assessed changes in medical knowledge and clinical confidence along with learner satisfaction, comparing responses using Wilcoxon‐signed rank tests and chi square analysis. We assessed the module's representation of light, medium, and dark skin tones with chi square analysis.ResultsThe module represented light, medium, and dark skin tones (χ2 = 4.788, P = 0.091) among 102 images (77.5%, n = 79) were novel images from authors’ personal libraries. Ninety‐four participants completed the postmodule test and evaluation survey. Analyses revealed significant improvement in medical knowledge identifying serologic studies associated with subacute CLE (χ2 = 14.035, P < 0.001) and describing how to photograph rashes (χ2 = 38.211, P < 0.001). Participants reported improved confidence across all learning objectives after module completion (P < 0.001).ConclusionThis module is the first to introduce an approach to assessing CLE across skin tones, effectively increasing medical knowledge and confidence among graduate medical trainees.
Design of Graphdiyne and Holey Graphyne‐Based Single Atom Catalysts for CO2 Reduction With Interpretable Machine Learning
Authors: Ren Manman , Guo Xiangyu , Zhang Shengli , Huang Shiping 
Published: July 2023

AbstractUsing electrochemical CO2 reduction reaction (CO2RR) to synthesize value‐added hydrocarbons provides a useful solution for environmental issues and energy crisis. However, this process is impeded by the low activity and selectivity of electrocatalysts toward targeted products. Employing density functional theory computations, the graphdiyne and holey graphyne supported single‐atom catalysts (SACs, M/GDY and M/HGY) are demonstrated to be the promising candidates for the CO2RR. By taking full elemental diversity of metal sites across the periodic table, 25 catalysts are found to effectively activate CO2 and inhibit competitive hydrogen evolution, and 8 of them show higher activity for CH4 production than Cu(211). Remarkably, changing supports are found to greatly affect limiting potentials and reaction pathways, even leading to an “inert‐active” transition for some metal centers. The resulting SACs, including Mn/GDY, Co/HGY, Ru/GDY, and Os/GDY, can achieve high activity with low limiting potentials of ≈ −0.22 to −0.58 V. Machine learning enables to identify the critical role of the polarized charge and magnetic moment of metal atoms in affecting the activity. The built machine learning model also shows an interpretable capability to predict the activity of the other types of SACs, offering a great promise to quick screening of high‐performance SACs.
Fluorination‐Induced Multi‐Enhancement of a Nano‐Photosensitizer for Deep Photodynamic Therapy against Hypoxia Tumor
Authors: Wei Kai , Wu Yanxin , Zheng Xian , Ma Guiping , Ji Chendong , Yin Meizhen 
Published: July 2023

AbstractOrganic dyes hold great promise for application in photodynamic therapy (PDT). However, they currently face challenges such as inadequate photodynamic activity, limited tumor penetration, and constraints imposed by tumor hypoxia. Here, a facile and efficient strategy is presented for multi‐enhanced PDT through the fluorination of a squarylium indocyanine dye‐based photosensitizer (FCy). The amphiphilic FCy features perfluorooctane and PEG‐biotin moieties conjugated to a squarylium indocyanine core. In aqueous environments, FCy spontaneously self‐assembles into stable nano‐sized photosensitizers (FCy NPs), demonstrating a high oxygen loading ability attributable to the presence of perfluoroalkyl groups. Consequently, the aggregation of squarylium indocyanine dyes remarkably boosts the photodynamic effect, yielding a 15‐fold improvement in singlet oxygen quantum yield. Owing to the perfluoroalkyl group, FCy NPs exhibit increased endoplasmic reticulum (ER)‐ accumulating abilities, which further induce ER stress upon laser irradiation and enhance the PDT effect. Furthermore, the superior deep tumor penetration ability of FCy NPs is confirmed through both in vitro and in vivo studies. With efficient oxygen supply to the deep tumor regions, FCy NPs demonstrate potent imaging‐guided PDT against hypoxia tumors. The study substantiates the enhanced ER‐accumulating ability of the perfluoroalkyl group and presents a facile fluorination strategy for the multi‐enhancement of photosensitizers.
All‐In‐One Optoelectronic Neuristor Based on Full‐vdW Two‐Terminal Ferroelectric p–n Heterojunction
Authors: Ci Wenjuan , Xue Wuhong , Wang Peng , Yin Wenhui , Wang Xiaoling , Shi Lei , Zhou Peng , Xu Xiaohong 
Published: July 2023

AbstractPhotoelectric synaptic devices with optical sensing capability are of great importance in simulating human vision systems. Especially realizing all‐in‐one vision neuristor on silicon based new materials and principles is being pursued. 2D van der Waals (vdW) materials have the unique advantage of arbitrary stacking on demand. Herein, a full‐vdW two‐terminal 2D ferroelectric α‐In2Se3/SnSe p–n heterojunction is proposed to construct an optoelectronic neuristor to simulate visual synaptic functions. Implementation of these simulations is attributed to the co‐modulation of the electrical polarization reconfigurable built‐in electric field caused by p–n junction and photo‐inducing ferroelectric polarization switching. These functions include ultra‐high paired‐pulse facilitation index (457%), short synaptic plasticity, long synaptic plasticity, and retina‐like optical adaptations. The high PPF is crucial for high‐precision decoding and processing of visual information. Meanwhile, the classical Pavlovian conditioned reflexes associated with associative learning are also emulated showing the ability of the device to handle complex electrical and optical inputs. This study demonstrates that two‐terminal ferroelectric p–n heterojunctions have great potential in high‐precision multifunctional optoelectronic visual synaptic devices.
Bandgap Engineering of BiIns Nanowire for Wide‐Spectrum, High‐Responsivity, and Polarimetric‐Sensitive Detection
Authors: Zhang Fen , Mo Zhangxun , Cui Baocheng , Liu Shuo , Xia Qinglin , Li Bo , Li Linwei , Zhang Zhengwei , He Jun , Zhong Mianzeng 
Published: July 2023

AbstractOptical devices based on alloying semiconductors offer a plethora of new possibilities for detection across a broad spectrum. Among these devices, nanowire‐based devices have gained much attention due to their remarkable specific surface area properties in terms of material synthesis, device structure, and performance. In this work, (BixIn1−x)2S3 nanowires are designed by controlling the ratio of Bi and In atoms. The atomic ratio directly affects the electronic band structure of the crystal, thereby further optimizing the performance of optoelectronic devices. According to the experimental results, Bi1.28In0.72S3 nanowire‐based photodetectors obtain the most excellent photoresponse performance. The typical device demonstrates a spectral response from deep ultraviolet (DUV 254 nm) to near‐infrared (NIR 1064 nm) and achieves a maximum dichroic ratio of photoresponse of 1.5 under polarization‐angle‐sensitive detection in the 266–808 nm range. It also exhibits a photoresponse of 10.1 A W−1 and a photodetectivity of 5.7 ×  1010 Jones under 532 nm light irradiation. Additionally, the photodetector displays a fast response speed with a rise/fall time of 5/4.7 ms. Finally, “CSU” and puppy images produced by this device further demonstrate the effectiveness of alloying semiconductors in creating wide‐spectrum, high‐responsivity, fast‐response, and polarimetric‐sensitive photodetectors.
Superoxide Dismutase‐Like Regulated Fe/Ppa@PDA/B for Synergistically Targeting Ferroptosis/Apoptosis to Enhance Anti‐Tumor Efficacy
Authors: Ding Xin , Wang Zidong , Yu Qiying , Michał Nowicki , Roman Szewczyk , Liu Yi , Peng Na 
Published: July 2023

AbstractThe cell apoptosis pathway of sonodynamic therapy (SDT) is usually blocked, resulting in limited therapeutic efficacy, therefore, the development of new methods for sensitizing targeted ferroptosis and promoting apoptosis is of great significance to improve the anti‐tumor efficacy of SDT. Herein, mesoporous Fe3O4 nanoparticles (NPs) are synthesized for loading pyropheophorbide‐a (ppa), surface‐coated by polydopamine (PDA) and further anchored with tumor‐targeting moieties of biotin to obtain Fe/ppa@PDA/B NPs. Fe/ppa@PDA/B displayes pH/ultrasound (US) responsive release properties, and magnetic resonance imaging (MRI) functions. Moreover, Fe3O4 NPs of Fe/ppa@PDA/B as the Fe source for ferroptosis, enhances ferroptosis sensitivity by consuming glutathione (GSH) and producing hydroxyl radical (OH). The quinone groups of PDA layer on Fe/ppa@PDA/B own free electrons, which led to effective superoxide dismutase (SOD) action through superoxide anion (O2−) disproportionation to hydrogen peroxide (H2O2) and oxygen (O2), thus, overcame hypoxia of SDT and promoted ·OH generation by Fe ions under US trigger, synergistically improves ferroptosis and apoptosis to enhance the anti‐tumor efficacy of SDT both in vitro and in vivo. The anti‐tumor strategy of synergistic apoptosis and ferroptosis induce by GSH depletion and self‐sufficient O2 regulated by SOD provides a new idea for enhancing SDT efficacy.