bluuebunny/crossref_metadata_2025_split huggingface dataset:
A synthesis of hydroclimatic, ecological, and socioeconomic data for transdisciplinary research in the Mekong
Authors: Tiwari Amar Deep , Pokhrel Yadu , Kramer Daniel , Akhter Tanjila , Tang Qiuhong , Liu Junguo , Qi Jiaguo , Loc Ho Huu , Lakshmi Venkataraman 
Published: May 2023

AbstractThe Mekong River basin (MRB) is a transboundary basin that supports livelihoods of over 70 million inhabitants and diverse terrestrial-aquatic ecosystems. This critical lifeline for people and ecosystems is under transformation due to climatic stressors and human activities (e.g., land use change and dam construction). Thus, there is an urgent need to better understand the changing hydrological and ecological systems in the MRB and develop improved adaptation strategies. This, however, is hampered partly by lack of sufficient, reliable, and accessible observational data across the basin. Here, we fill this long-standing gap for MRB by synthesizing climate, hydrological, ecological, and socioeconomic data from various disparate sources. The data— including groundwater records digitized from the literature—provide crucial insights into surface water systems, groundwater dynamics, land use patterns, and socioeconomic changes. The analyses presented also shed light on uncertainties associated with various datasets and the most appropriate choices. These datasets are expected to advance socio-hydrological research and inform science-based management decisions and policymaking for sustainable food-energy-water, livelihood, and ecological systems in the MRB.
Influence of well-being and quality of work-life on quality of care among healthcare professionals in southwest, Nigeria
Authors: Odole Adesola C. , Ogunlana Michael O. , Odunaiya Nse A. , Oyewole Olufemi O. , Mbada Chidozie E. , Onyeso Ogochukwu K. , Ayodeji Ayomikun F. , Adegoke Opeyemi M. , Odole Iyanuoluwa , Sanuade Comfort T. , Odole Moyosooreoluwa E. , Awosoga Oluwagbohunmi A. 
Published: May 2023

AbstractThe Nigerian healthcare industry is bedevilled with infrastructural dilapidations and a dysfunctional healthcare system. This study investigated the influence of healthcare professionals’ well-being and quality of work-life (QoWL) on the quality of care (QoC) of patients in Nigeria. A multicentre cross-sectional study was conducted at four tertiary healthcare institutions in southwest, Nigeria. Participants’ demographic information, well-being, quality of life (QoL), QoWL, and QoC were obtained using four standardised questionnaires. Data were summarised using descriptive statistics. Inferential statistics included Chi-square, Pearson’s correlation, independent samples t-test, confirmatory factor analyses and structural equation model. Medical practitioners (n = 609) and nurses (n = 570) constituted 74.6% of all the healthcare professionals with physiotherapists, pharmacists, and medical laboratory scientists constituting 25.4%. The mean (SD) participants’ well-being = 71.65% (14.65), QoL = 61.8% (21.31), QoWL = 65.73% (10.52) and QoC = 70.14% (12.77). Participants’ QoL had a significant negative correlation with QoC while well-being and quality of work-life had a significant positive correlation with QoC. We concluded that healthcare professionals’ well-being and QoWL are important factors that influence the QoC rendered to patients. Healthcare policymakers in Nigeria should ensure improved work-related factors and the well-being of healthcare professionals to ensure good QoC for patients.
Increased risk of herpes zoster with tofacitinib treatment in Korean patients with rheumatoid arthritis: a single-center prospective study
Authors: Song Yeo-Jin , Cho Soo-Kyung , Kim Hyoungyoung , Kim Hye Won , Nam Eunwoo , Jeon Ja-Young , Yoo Hyun-Jeong , Choi Chan-Bum , Kim Tae-Hwan , Jun Jae-Bum , Bae Sang-Cheol , Yoo Dae Hyun , Sung Yoon-Kyoung 
Published: May 2023

AbstractWe aimed to determine the risk of herpes zoster (HZ) in Korean rheumatoid arthritis (RA) patients on tofacitinib compared with tumor necrosis factor inhibitor (TNFi) treatment. From the prospective cohorts of RA patients who started tofacitinib or TNFi in an academic referral hospital in Korea, patients who started tofacitinib between March 2017 and May 2021 and those who started TNFi between July 2011 and May 2021 were included. Baseline characteristics of tofacitinib and TNFi users were balanced through inverse probability of treatment weighting (IPTW) using the propensity score including age, disease activity of RA and medication use. The incidence rate of HZ in each group and incidence rate ratio (IRR) were calculated. A total of 912 patients were included: 200 tofacitinib and 712 TNFi users. There were 20 cases of HZ among tofacitinib users and 36 among TNFi users during observation period of 331.4 person-years (PYs) and 1950.7 PYs, respectively. In IPTW analysis with a balanced sample, IRR of HZ was 8.33 (95% confidence interval 3.05–22.76). Tofacitinib use increased the risk of HZ compared with TNFi in Korean patients with RA, but the rate of serious HZ or permanent discontinuation of tofacitinib due to HZ event was low.
A peleg modeling of water absorption in cold plasma-treated Chickpea (Cicer arietinum L.) cultivars
Authors: Pathan F. L. , Trimukhe A. M. , Deshmukh R. R. , Annapure U. S. 
Published: May 2023

AbstractPlasma processing appears to be the mainstay of food preservation in the present day due to its effectiveness in controlling microorganisms at low temperatures. Legumes are usually soaked before cooking. Six chickpea varieties (Kripa, Virat, Vishal, Vijay, Digvijay, and Rajas) were soaked in distilled water at room temperature, and Peleg model was fitted after plasma treatment. Cold plasma treatment was used at 40, 50 and 60 Watt with exposure times of 10, 15 and 20 min. K1 (Peleg rate constant) consistently decreased from 32.3 to 4.3 × 10–3 (h % − 1) for all six chickpea cultivars, indicating an increased water absorption rate with increasing plasma power and treatment time. It was lowest in 60 W 20 min plasma treatment in Virat cultivar. K2 (Peleg capacity constant) ranged from 9.4 to 12 × 10–3 (h % − 1) for all six chickpea cultivars. Thus, plasma treatment showed no effect on water uptake capacity (K2), as it did not increase or decrease consistently with increasing plasma power and treatment time. Fitting the Peleg model successfully revealed the correlation between the water absorption of chickpea cultivars. The model fit ranged from R2 ≥ 0.9873 to 0.9981 for all six chickpea cultivars.
Causal relationships between serum matrix metalloproteinases and estrogen receptor-negative breast cancer: a bidirectional mendelian randomization study
Authors: Zhao Zijun , Cao Qing , Zhu Ming , Wang Chaonan , Lu Xin 
Published: May 2023

AbstractTo better clarify the causal effects between matrix metalloproteinases (MMPs) and estrogen-receptor (ER)-negative breast cancer (BC), we investigated the bidirectional causal relationship between MMPs and ER-negative BC by mendelian randomization (MR) analysis. Summary statistic data of five MMPs were extracted from European participants in 13 cohorts. Data of ER-negative BC collected from one of genome-wide association studies of European ancestry was used as experimental datasets and another four ER-negative BC datasets were used as validation sets. Inverse variance weighted method was used for main MR analysis and sensitivity analysis was also conducted. Serum level of MMP-1 has negative effect on ER-negative BC (odds ratio = 0.92, P = 0.0008) but the latter one was not the cause of the former one, which was supported by validation sets. No bidirectional causal effect was detected between the other four types of MMPs and ER-negative BC (P > 0.05). Sensitivity analysis indicated robustness of the above results without remarkable bias. To conclude, serum MMP-1 may be a protective factor against ER-negative BC. No reciprocal causality was found between the other kinds of MMPs and ER-negative BC. MMP-1 was indicated as a biomarker for risk of ER-negative BC.
Ticks harbor and excrete chronic wasting disease prions
Authors: Inzalaco H. N. , Bravo-Risi F. , Morales R. , Walsh D. P. , Storm D. J. , Pedersen J. A. , Turner W. C. , Lichtenberg S. S. 
Published: May 2023

AbstractChronic wasting disease (CWD) is a fatal neurodegenerative disease caused by infectious prions (PrPCWD) affecting cervids. Circulating PrPCWD in blood may pose a risk for indirect transmission by way of hematophagous ectoparasites acting as mechanical vectors. Cervids can carry high tick infestations and exhibit allogrooming, a common tick defense strategy between conspecifics. Ingestion of ticks during allogrooming may expose naïve animals to CWD, if ticks harbor PrPCWD. This study investigates whether ticks can harbor transmission-relevant quantities of PrPCWD by combining experimental tick feeding trials and evaluation of ticks from free-ranging white-tailed deer (Odocoileus virginianus). Using the real-time quaking-induced conversion (RT-QuIC) assay, we show that black-legged ticks (Ixodes scapularis) fed PrPCWD-spiked blood using artificial membranes ingest and excrete PrPCWD. Combining results of RT-QuIC and protein misfolding cyclic amplification, we detected seeding activity from 6 of 15 (40%) pooled tick samples collected from wild CWD-infected white-tailed deer. Seeding activities in ticks were analogous to 10–1000 ng of CWD-positive retropharyngeal lymph node collected from deer upon which they were feeding. Estimates revealed a median infectious dose range of 0.3–42.4 per tick, suggesting that ticks can take up transmission-relevant amounts of PrPCWD and may pose a CWD risk to cervids.
Analysis of the difference between early-bolting and non-bolting roots of Angelica dahurica based on transcriptome sequencing
Authors: Wu Ping , Wang Xiaoyu , Guo Junxia , Zhang Songli , Li Qingmiao , Zhang Mei , Fang Qingmao , Luo Bin , Wang Hongsu , He Weijin 
Published: May 2023

AbstractAngelica dahurica (Fisch. ex Hoffm.) Benth.et Hook.f.var.formosana (Boiss.) Shan et Yuan (A. dahurica) is a well-known medicinal plant that has a wide range of applications in the pharmaceutical, food, cosmetic, and other industries. However, the issue of early bolting has emerged as a major hindrance to its production. This problem not only reduces the yield of A. dahurica, but also has an impact on its active ingredients. To date, the molecular factors that contribute to early bolting and its impact on the growth of A. dahurica have not been thoroughly investigated. Therefore, we conducted a transcriptome study using the Illumina NovaSeq 6000 on two developmental types: early-bolting and non-bolting (normal) roots of A. dahurica. We obtained 2,185 up-regulated and 1,414 down-regulated genes in total. Many of the identified transcripts were related to genes involved in early bolting. The gene ontology analysis revealed several differentially expressed genes that are crucial in various pathways, primarily associated with cellular, molecular, and biological processes. Additionally, the morphological characteristics and coumarin content in the early bolting roots of A. dahurica were significantly altered. This study provides insight into the transcriptomic regulation of early bolting in A. dahurica, which can potentially be utilized to enhance its medicinal properties.
Red background color biases gender categorization of human faces
Authors: Chen Na , Nakamura Koyo , Watanabe Katsumi 
Published: May 2023

AbstractColor carries gender information (e.g., red-female). This study explored whether background color could influence the gender categorization of human faces. Visual stimuli were generated from faces whose sexually dimorphic content was morphed monotonically from female to male perception. The face stimulus was presented upright (Experiment 1) and inverted (Experiment 2) with three background colors (i.e., red, green, and gray). Participants were instructed to categorize the gender of the face stimulus as male or female by pressing one of two labelled keys. Results showed that a red background could bias the gender of an ambiguous upright face toward a female compared with green and gray background colors (Experiment 1). However, this red effect was diminished when the face stimulus was inverted (Experiment 2). These results suggest that red background color interacting with facial configuration features biases gender perception toward a female face, possibly through top-down processing of learned associations between the color red and femininity.
Cluster analysis of autoencoder-extracted FDG PET/CT features identifies multiple myeloma patients with poor prognosis
Authors: Lee Hyunjong , Hyun Seung Hyup , Cho Young Seok , Moon Seung Hwan , Choi Joon Young , Kim Kihyun , Lee Kyung-Han 
Published: May 2023

AbstractF-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a robust imaging modality used for staging multiple myeloma (MM) and assessing treatment responses. Herein, we extracted features from the FDG PET/CT images of MM patients using an artificial intelligence autoencoder algorithm that constructs a compressed representation of input data. We then evaluated the prognostic value of the image-feature clusters thus extracted. Conventional image parameters including metabolic tumor volume (MTV) were measured on volumes-of-interests (VOIs) covering only the bones. Features were extracted with the autoencoder algorithm on bone-covering VOIs. Supervised and unsupervised clustering were performed on image features. Survival analyses for progression-free survival (PFS) were performed for conventional parameters and clusters. In result, supervised and unsupervised clustering of the image features grouped the subjects into three clusters (A, B, and C). In multivariable Cox regression analysis, unsupervised cluster C, supervised cluster C, and high MTV were significant independent predictors of worse PFS. Supervised and unsupervised cluster analyses of image features extracted from FDG PET/CT scans of MM patients by an autoencoder allowed significant and independent prediction of worse PFS. Therefore, artificial intelligence algorithm–based cluster analyses of FDG PET/CT images could be useful for MM risk stratification.
KCC2 downregulation after sciatic nerve injury enhances motor function recovery
Authors: Cheung Dennis Lawrence , Toda Takuya , Narushima Madoka , Eto Kei , Takayama Chitoshi , Ooba Tatsuko , Wake Hiroaki , Moorhouse Andrew John , Nabekura Junichi 
Published: May 2023

AbstractInjury to mature neurons induces downregulated KCC2 expression and activity, resulting in elevated intracellular [Cl−] and depolarized GABAergic signaling. This phenotype mirrors immature neurons wherein GABA-evoked depolarizations facilitate neuronal circuit maturation. Thus, injury-induced KCC2 downregulation is broadly speculated to similarly facilitate neuronal circuit repair. We test this hypothesis in spinal cord motoneurons injured by sciatic nerve crush, using transgenic (CaMKII-KCC2) mice wherein conditional CaMKIIα promoter-KCC2 expression coupling selectively prevents injury-induced KCC2 downregulation. We demonstrate, via an accelerating rotarod assay, impaired motor function recovery in CaMKII-KCC2 mice relative to wild-type mice. Across both cohorts, we observe similar motoneuron survival and re-innervation rates, but differing post-injury reorganization patterns of synaptic input to motoneuron somas—for wild-type, both VGLUT1-positive (excitatory) and GAD67-positive (inhibitory) terminal counts decrease; for CaMKII-KCC2, only VGLUT1-positive terminal counts decrease. Finally, we recapitulate the impaired motor function recovery of CaMKII-KCC2 mice in wild-type mice by administering local spinal cord injections of bicuculline (GABAA receptor blockade) or bumetanide (lowers intracellular [Cl−] by NKCC1 blockade) during the early post-injury period. Thus, our results provide direct evidence that injury-induced KCC2 downregulation enhances motor function recovery and suggest an underlying mechanism of depolarizing GABAergic signaling driving adaptive reconfiguration of presynaptic GABAergic input.
Occupational radiation exposure to the lens of the eyes and its protection during endoscopic retrograde cholangiopancreatography
Authors: Ikezawa Kenji , Hayashi Shiro , Takenaka Mamoru , Yakushijin Takayuki , Nagaike Koji , Takada Ryoji , Yamai Takuo , Matsumoto Kengo , Yamamoto Masashi , Omoto Shunsuke , Minaga Kosuke , Ishii Shuji , Shimizu Takeshi , Nagai Kengo , Hosono Makoto , Nishida Tsutomu 
Published: May 2023

AbstractThis study aimed to examine occupational radiation exposure to the lens of the eyes during endoscopic retrograde cholangiopancreatography (ERCP). In this multicenter, prospective, observational cohort study, we collected data regarding occupational radiation exposure to the lens of the eyes during ERCP. We measured radiation exposure of patients and examined its correlation with occupational exposure. In dosimetrically-measured ERCPs (n = 631), the median air kerma at the patient entrance reference point, air kerma-area product, and fluoroscopy time were 49.6 mGy, 13.5 Gycm2, and 10.9 min, respectively. The median estimated annual radiation dose to the lens of the eyes was 3.7, 2.2, and 2.4 mSv for operators, assistants, and nurses, respectively. Glass badge over lead aprons and eye dosimeter results were similar in operators but differed in assistants and nurses. A strong correlation was shown between eye dosimeter measurements and patients' radiation exposure. The shielding rates of the lead glasses were 44.6%, 66.3%, and 51.7% for operators, assistants, and nurses, respectively. This study revealed the actual occupational exposure dose for the lens of the eyes during ERCP and the efficacy of lead glass. Values of radiation exposure to patients can help estimate exposure to the lens of the eyes of medical staff.
Integration of MRI and somatosensory evoked potentials facilitate diagnosis of spinal cord compression
Authors: Sun Shu-Pin , Phang Chun-Ren , Tzou Shey-Cherng , Chen Chang-Mu , Ko Li-Wei 
Published: May 2023

AbstractThis study aimed to integrate magnetic resonance imaging (MRI) and related somatosensory evoked potential (SSEP) features to assist in the diagnosis of spinal cord compression (SCC). MRI scans were graded from 0 to 3 according to the changes in the subarachnoid space and scan signals to confirm differences in SCC levels. The amplitude, latency, and time–frequency analysis (TFA) power of preoperative SSEP features were extracted and the changes were used as standard judgments to detect neurological function changes. Then the patient distribution was quantified according to the SSEP feature changes under the same and different MRI compression grades. Significant differences were found in the amplitude and TFA power between MRI grades. We estimated three degrees of amplitude anomalies and power loss under each MRI grade and found the presence or absence of power loss occurs after abnormal changes in amplitude only. For SCC, few integrated approach combines the advantages of both MRI and evoked potentials. However, integrating the amplitude and TFA power changes of SSEP features with MRI grading can help in the diagnosis and speculate progression of SCC.
Vaginal birth after cesarean section and its associated factors in Ethiopia: a systematic review and meta-analysis
Authors: Addisu Dagne , Gebeyehu Natnael Atnafu , Biru Shimeles , Belachew Yismaw Yimam 
Published: May 2023

AbstractThe prevalence of cesarean sections is rising rapidly and is becoming a global issue. Vaginal birth after a cesarean section is one of the safest strategies that can be used to decrease the cesarean section rate. Different fragmented primary studies were done on the success rate of vaginal birth after cesarean section and its associated factors in Ethiopia. However, the findings were controversial and inconclusive. Therefore, this meta-analysis was intended to estimate the pooled success rate of vaginal birth after cesarean section and its associated factors in Ethiopia. Pertinent studies were searched in PubMed, Google Scholar, ScienceDirect, direct open-access journals, and Ethiopian universities' institutional repositories. The data were analyzed using Stata 17. The Newcastle–Ottawa quality assessment tool was used to assess the quality of the studies. I squared statistics and Egger’s regression tests were used to assess heterogeneity and publication bias, respectively. A random effects model was selected to estimate the pooled success rate of vaginal birth after cesarean section and its associated factors. The PROSPERO registration number for this review is CRD42023413715. A total of 10 studies were included. The pooled success rate of vaginal birth after a cesarean section was found to be 48.42%. Age less than 30 years (pooled odds ratio (OR) 3.75, 95% CI 1.92, 7.33), previous history of vaginal birth (OR 3.65, 95% CI 2.64, 504), ruptured amniotic membrane at admission (OR 2.87, 95% CI 1.94, 4.26), 4 cm or more cervical dilatation at admission (OR 4, 95% CI 2.33, 6.8), a low station at admission (OR 5.07, 95% CI 2.08, 12.34), and no history of stillbirth (OR 4.93, 95% CI 1.82, 13.36) were significantly associated with successful vaginal birth after cesarean section. In conclusion, the pooled success rate of vaginal birth after a cesarean section was low in Ethiopia. Therefore, the Ministry of Health should consider those identified factors and revise the management guidelines and eligibility criteria for a trial of labor after a cesarean section.
Proof of principle study: synchrotron X-ray fluorescence microscopy for identification of previously radioactive microparticles and elemental mapping of FFPE tissues
Authors: Copeland-Hardin Letonia , Paunesku Tatjana , Murley Jeffrey S. , Crentsil Jasson , Antipova Olga , Li LuXi , Maxey Evan , Jin Qiaoling , Hooper David , Lai Barry , Chen Si , Woloschak Gayle E. 
Published: May 2023

AbstractBiobanks containing formalin-fixed, paraffin-embedded (FFPE) tissues from animals and human atomic-bomb survivors exposed to radioactive particulates remain a vital resource for understanding the molecular effects of radiation exposure. These samples are often decades old and prepared using harsh fixation processes which limit sample imaging options. Optical imaging of hematoxylin and eosin (H&E) stained tissues may be the only feasible processing option, however, H&E images provide no information about radioactive microparticles or radioactive history. Synchrotron X-ray fluorescence microscopy (XFM) is a robust, non-destructive, semi-quantitative technique for elemental mapping and identifying candidate chemical element biomarkers in FFPE tissues. Still, XFM has never been used to uncover distribution of formerly radioactive micro-particulates in FFPE canine specimens collected more than 30 years ago. In this work, we demonstrate the first use of low-, medium-, and high-resolution XFM to generate 2D elemental maps of ~ 35-year-old, canine FFPE lung and lymph node specimens stored in the Northwestern University Radiobiology Archive documenting distribution of formerly radioactive micro-particulates. Additionally, we use XFM to identify individual microparticles and detect daughter products of radioactive decay. The results of this proof-of-principle study support the use of XFM to map chemical element composition in historic FFPE specimens and conduct radioactive micro-particulate forensics.