bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated heterodyne laser Doppler vibrometer based on stress-optic frequency shift in silicon nitride
Authors: Raptakis Adam , Gounaridis Lefteris , Epping Jörn P. , Tran Thi Lan Anh , Aukes Thomas , Kleinert Moritz , Weigel Madeleine , Wolfer Marco , Draebenstedt Alexander , Tsokos Christos , Groumas Panos , Andrianopoulos Efstathios , Lyras Nikos , Nikolaidis Dimitrios , Mylonas Elias , Baxevanakis Nikolaos , Pessina Roberto , Schreuder Erik , Dekkers Matthijn , Seyfried Volker , Keil Norbert , Heideman René G. , Avramopoulos Hercules , Kouloumentas Christos 
Published: September 2023

AbstractWe demonstrate a compact heterodyne Laser Doppler Vibrometer (LDV) based on the realization of optical frequency shift in the silicon nitride photonic integration platform (TriPleX). We theoretically study, and experimentally evaluate two different photonic integrated optical frequency shifters (OFSs), utilizing serrodyne and single-sideband (SSB) modulation. Both OFSs employ stress-optic modulators (SOMs) based on the non-resonant piezoelectrical actuation of lead zirconate titanate (PZT) thin-films, deposited on top of the silicon nitride waveguides with a wafer-scale process. To improve the modulation bandwidth of the SOMs we investigate a novel configuration of the electrodes used for the actuation, where both electrodes are placed on top of the PZT layer. Using this top-top electrode configuration we report frequency shift of 100 kHz and 2.5 MHz, and suppression ratio of the unwanted sidebands of 22.1 dB and 39 dB, using the serrodyne and the SSB OFS, respectively. The best performing SOM structure induces 0.25π peak-to-peak sinusoidal phase-shift with 156 mW power dissipation at 2.5 MHz. We use the SSB-OFS in our compact LDV system to demonstrate vibration measurements in the kHz regime. The system comprises a dual-polarization coherent detector built in the PolyBoard platform, utilizing hybrid integration of InP photodiodes (PDs). High quality LDV performance with measurement of vibration frequencies up to several hundreds of kHz and displacement resolution of 10 pm are supported with our system.
Acinetobacter baumannii biofilm and its potential therapeutic targets
Authors: Mohamed Eman Abdelbaset , Raafat Marwa M. , Samir Mohamed Reham , Ali Amal Emad Eldin 
Published: September 2023

Abstract
Background
Acinetobacter baumannii (A. baumannii) is an opportunistic pathogen that poses dangerous health threat. It is a main cause of biofilm-associated infections that are mostly resistant to antibiotic therapy. Because of its capacity to form biofilm on biotic and abiotic surfaces, it has been linked to most nosocomial infections such as ventilator-associated pneumonia, urinary tract infections, bacteremia, meningitis, wound infections, soft tissue infections, and peritonitis.

Main body of the abstract
The biofilm refers to an organized group of microbial cells that are embedded in an exopolymeric substance made of protein, extracellular DNA, and polysaccharide. Bacterial cells in biofilms are resistant to chemicals, phagocytosis, and other elements of the body’s innate and acquired immune systems posing treatment challenges. Biofilm formation in A. baumannii is a complicated process that is influenced by a variety of factors such as outer membrane protein A, poly-β-(1,6)-N acetyl glucosamine (PAGE), biofilm-associated protein, two-component system (Bfm/S BfmR), chaperone–usher (Csu) pilus assembly system of pili, BlaPER-1 belonging to β-lactamase family, extracellular polymeric substance, and the quorum sensing system. Several biofilm-associated genes influence antimicrobial susceptibility, implying a link between biofilm formation and antimicrobial resistance.

Short conclusion
This review describes the complex biofilm system of A. baumannii, which gives it a survival advantage and increases its colonization ability. Also, it demonstrates various extrinsic and intrinsic factors that function and regulate the biofilm machinery of A. baumannii. Furthermore, this study considers prospective ways for preventing biofilm development on relevant medical equipment, as well as potential therapeutic strategies for eradicating mature biofilms, which can aid in the treatment of biofilm-associated A. baumannii infection.
‘Phototaxis’ in the absence of light? Locomotory patterns in unionid mussels
Authors: Zapitis Charitos , Ramsey Andrew , Huck Maren , Landler Lukas , Burian Alfred 
Published: September 2023

ABSTRACT
Locomotion in benthic invertebrates can strongly affect habitat selection and ecosystem nutrient cycling. In the case of freshwater mussels, the drivers of locomotion are largely unresolved. Our aim was to assess the influence of light presence and intensity on the locomotory behaviour of freshwater mussels in controlled laboratory experiments. The species investigated in our study were Anodonta anatina and Unio pictorum, two widely distributed mussels in European lentic and lotic inland waters. At low algal concentrations, known to be associated with more frequent locomotory activities, we found that both species moved primarily in the absence of light (72.7% of all movements across experiments). However, the movements of both species were directed towards the light source, resembling a net-positive ‘phototactic’ response but in the absence of light. The distance to the light source, which was negatively correlated to light intensity, had a positive effect on the distance covered in locomotory activities by A. anatina but not by U. pictorum. Intraspecific variation in shell size had no impact on movement distance, indicating that the energetic costs of movement were not a limiting factor. We suggest that the observed movement towards brighter locations helps to enhance food quantity and quality, whilst movement in darkness mitigates predation risks.
Higher-order dialectic variation and syntactic convergence in the complex warble song of budgerigars
Authors: Madabhushi Abhinava Jagan , Wewhare Nakul , Binwal Priya , Agarwal Vaishnavi , Krishnan Anand 
Published: September 2023

ABSTRACT
Dialectic signatures in animal acoustic signals are key in the identification of and association with group members. Complex vocal sequences may also convey information about behavioral state, and may thus vary according to social environment. Some bird species, such as psittaciforms, learn and modify their complex acoustic signals throughout their lives. However, the structure and function of vocal sequences in open-ended vocal learners remains understudied. Here, we examined vocal sequence variation in the warble song of budgerigars, and how these change upon contact between social groups. Budgerigars are open-ended vocal learners which exhibit fission–fusion flock dynamics in the wild. We found that two captive colonies of budgerigars exhibited colony-specific differences in the syntactic structure of their vocal sequences. Individuals from the two colonies differed in the propensity to repeat certain note types, forming repetitive motifs which served as higher-order signatures of colony identity. When the two groups were brought into contact, their vocal sequences converged, and these colony-specific repetitive patterns disappeared, with males from both erstwhile colonies now producing similar sequences with similar syntactic structure. We present data suggesting that the higher-order temporal arrangement of notes/vocal units is modified throughout life by social learning as groups of birds continually associate and dissociate. Our study sheds light on the importance of examining signal structure at multiple levels of organization, and the potential for psittaciform birds as model systems to examine the influence of learning and social environment on acoustic signals.
Contrast sensitivity, visual acuity and the effect of behavioural state on optokinetic gain in fiddler crabs
Authors: Perez Monika , Bagheri Zahra M. , Brown Courtney , Ogawa Yuri , Partridge Julian C. , Hemmi Jan M. 
Published: September 2023

ABSTRACT
Most animals rely on visual information for a variety of everyday tasks. The information available to a visual system depends in part on its spatial resolving power and contrast sensitivity. Because of their competing demands for physical space within an eye, these traits cannot simultaneously be improved without increasing overall eye size. The contrast sensitivity function is an integrated measure of visual performance that measures both resolution and contrast sensitivity. Its measurement helps us identify how different species have made a trade-off between contrast sensitivity and spatial resolution. It further allows us to identify the evolutionary drivers of sensory processing and visually mediated behaviour. Here, we measured the contrast sensitivity function of the fiddler crab Gelasimus dampieri using its optokinetic responses to wide-field moving sinusoidal intensity gratings of different orientations, spatial frequencies, contrasts and speeds. We further tested whether the behavioural state of the crabs (i.e. whether crabs are actively walking or not) affects their optokinetic gain and contrast sensitivity. Our results from a group of five crabs suggest a minimum perceived contrast of 6% and a horizontal and vertical visual acuity of 0.4 cyc deg−1 and 0.28 cyc deg−1, respectively, in the crabs' region of maximum optomotor sensitivity. Optokinetic gain increased in moving crabs compared with restrained crabs, adding another example of the importance of naturalistic approaches when studying the performance of animals.
Optimisation of pipes with constant diameter using the heuristic optimality criterion
Authors: Blacher David , Harasek Michael 
Published: September 2023

Background: Minimising internal pressure drop in pipes is crucial for energy efficiency of fluid flow applications. Numerous computational optimisation tools that are capable of modifying flow geometries to reduce the pressure drop have been developed. Among these is a comparably simple heuristic optimisation algorithm which mimics erosion and sedimentation processes based on the shear stress in the vicinity of the domain boundaries. Although this method succeeds in modifying flow geometries for reduced pressure drop, it allows the fluid domain to widen during the reshaping process. Therefore, a reported reduction of pressure drop is not only caused by an improvement of the flow path, but also by an increase in the domain width. However, pipes with a constant circular diameter are favoured in many applications because they can be easily manufactured. Methods: Here we combine the heuristic optimisation approach with a new geometrical constraint that kept the average diameter constant. This way, a reduction of pressure drop caused solely by the modification of the flow path can be assessed. We determined the applicability of the modified algorithm for 2D channel and 3D pipe geometries, conducting numerical simulations using the Lattice Boltzmann method with Reynolds numbers ranging from 40 to 500. Results: For all investigated cases, potentially optimal shapes could be derived at all tested Reynolds numbers. However, the shape originally derived at a simulated flow with Re = 40 yielded a smaller pressure drop even for flows at Re ≥ 100 than shapes derived specifically at these higher Reynolds numbers. Conclusions: This observed trend should be kept in mind when employing this approach as a simple way to improve channel and pipe layouts.
Position and Differentiation of Firms in Technology Space
Authors: Arts Sam , Cassiman Bruno , Hou Jianan 
Published: September 2023

Although the rate of invention by firms and the effect on firm performance have been central themes in economics and strategy, the position and differentiation of invention by firms have received less attention. We develop a method to characterize a firm’s technology portfolio based on the semantic content of patents that allows us to map a firm’s unique spatial position relative to every other firm in technology space and to measure the overall differentiation of a firm’s technology portfolio. Using a large panel of U.S. public firms from 1980 to 2015, we illustrate that technology differentiation has a strong positive correlation with firm performance, particularly in research and development-intensive industries and industries with strong product market rivalry. We also show that technology differentiation is associated with subsequent differentiation from competitors in the product market and a reduction in outgoing technology spillovers to other firms. We provide open access to code and data to characterize the technology portfolio of firms and to measure the technological position and differentiation of U.S. public firms. This paper was accepted by Alfonso Gambardella, business strategy. Funding: S. Arts acknowledges support from KU Leuven [Grant 3H200208] and National Bank Belgium [Grant 3H160338]. B. Cassiman acknowledges support from Fonds Wetenschappelijk Onderzoek - Vlaanderen [Grant G071417N]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.00282 .
Drying and Quality Characteristics of Whole Jujubes Subjected to Air Assisted Radio Frequency Heating
Authors: Li Rui , Ni Bo , Yang Gaoji , Xu Juanjuan , Wang Kunhua , Guan Xiangyu , Wang Shaojin 
Published: September 2023

Highlights

The effect of air temperature and electrode gap (EG) on RF drying efficiency was evaluated.

Drying rate (Dr), the mathematical modeling of drying curves, heating uniformity, effective moisture diffusivity coefficient (Deff), and quality parameters after drying were analyzed.

Drying rate was accelerated by reducing EG or increasing air temperature under EG RF drying.

The trend of heating uniformity was the same as that of Deff value.

The evaluated quality parameters of treated whole jujubes showed that 40°C air assisted 17 cm EG RF drying had the best quality.

Abstract. This study aims to investigate the drying and quality characteristics of whole jujubes heated by air assisted radio frequency (RF) energy. The effect of air temperature and electrode gap (EG) on RF drying efficiency was evaluated. The drying rate (Dr), the mathematical modeling of drying curves, heating uniformity, effective moisture diffusivity coefficient (Deff), and quality parameters after drying were analyzed. The results showed that under the conditions of 30°C air temperature or 17 cm EG RF drying, Dr was accelerated by reducing EG from 18 cm to 16 cm or increasing air temperature from 20°C to 40°C. The Midilli model had the best fitting to drying curves under 30°C RF treatments with 16 cm, 17 cm, and 18 cm EG, and 40°C RF heating with 17 cm EG conditions. But the Logarithmic model was better for 20°C air assisted 17 cm EG RF heating due to the largest R2 with lowest RMSE. The largest Deff value was shown at 40°C air assisted 17 cm EG RF drying, followed by 30°C air assisted 16 cm, 17 cm, and 18 cm EG RF heating, and 20°C air assisted 17 cm EG RF drying. The trend of heating uniformity was the same as that of the Deff value. The evaluated quality parameters of treated whole jujubes showed that 40°C air assisted 17 cm EG RF drying had the best quality. Therefore, 40°C air assisted 17 cm EG RF heating was chosen for drying jujubes due to its faster drying rate and better quality. Keywords: Air temperature, Drying characteristics, Jujube; Quality, Radio frequency heating.
Acne accounts for an almost 2.5-fold higher proportion of dermatology visits among adult females compared to adult males in the United States: A study of the national ambulatory medical care survey from 2002–2016
Authors: Chang Jungsoo , Nock Michael R. , Cohen Jeffrey M. , Bunick Christopher G. 
Published: September 2023

Background
Acne vulgaris affects a significant number of females into adulthood. Juvenile acne and adult acne have different presentations and potentially distinctive pathogeneses. However, patterns in treatments specifically related to the adult female population have previously not been studied.

Methods
Retrospective database analysis of healthcare utilization and medications prescribed for acne using the National Ambulatory Medical Care Survey (NAMCS) data from 2002–2016 was performed.

Results
After age 20, acne accounted for an almost 2.5-fold higher proportion of dermatology visits among females compared to males (10.1% vs. 4.1%, P < 0.001). Tetracycline-class antibiotics were the most prescribed therapy within all age groups of females between 2002–2016. However, there was also a substantial rise in prescriptions of spironolactone beginning in 2012.

Conclusion
A significantly greater proportion of dermatology visits by adult females are for acne in comparison to adult males. Tetracycline-class antibiotics remain the most prescribed therapy in adult age groups despite a potentially different pathogenesis of adult acne. Therefore, there is a need for further studies comparing the effectiveness of therapies specifically for adult female acne.
Meta-analysis of outcomes from drug-eluting stent implantation in femoropopliteal arteries
Authors: Li Mingxuan , Tu Haixia , Yan Yu , Guo Zhen , Zhu Haitao , Niu Jiangliang , Yin Mengchen 
Published: September 2023

ObjectiveIn recent years, studies of drug-eluting stent (DES) for femoropopliteal artery diseases (FPADs) have been gradually published. To explore whether this type of stent is superior to the traditional bare metal stent (BMS), we performed this study.MethodsA systematic search for randomized controlled trials (RCTs) in Excerpta Medica Database (Embase), PubMed, Web of Science (WOS), and Cochrane Library was performed on November 29, 2022. We innovatively adopted the hazard ratio (HR), the most appropriate indicator, as a measure of the outcomes that fall under the category of time-to-event data. The HRs was extracted directly or indirectly. Then, the meta-analyses using random effects model were performed. The bias risks of included papers were assessed by the Cochrane Risk of Bias 2.0 tool. This study was registered on the PROSPER platform (CRD42023391944) and not funded.ResultsSeven RCTs involving 1,889 participants were found. After pooled analyses, we obtained results without propensity on each of the following 3 outcomes of interest: in-stent restenosis (ISR) -free survival, primary patency (PP) survival, and target lesion revascularization (TLR) -free survival (P >0.05, respectively). Because the results of pooled analyses of the other two outcomes of interest (all-cause death free survival and clinical benefit survival) had high heterogeneity both, they were not accepted by us.ConclusionFor FPADs, the DES has not yet demonstrated superiority or inferiority to BMS, in the ability to maintain PP, avoid ISR and TLR.
A systematic review on the detection of volatile organic compounds in exhaled breath in experimental animals in the context of gastrointestinal and hepatic diseases
Authors: Hintzen Kim F.H. , Eussen Myrthe M.M. , Neutel Céline , Bouvy Nicole D. , van Schooten Frederik-Jan , Hooijmans Carlijn R. , Lubbers Tim 
Published: September 2023

Background
Analysis of volatile organic compounds (VOCs) in exhaled breath has the potential to serve as an accurate diagnostic tool for gastro-intestinal diseases. Animal studies could be instrumental as a preclinical base and subsequent clinical translation to humans, as they are easier to standardize and better equipped to relate specific VOCs to metabolic and pathological processes. This review provides an overview of the study design, characteristics and methodological quality of previously published animal studies on analysis of exhaled breath in gastrointestinal and hepatic diseases. Guidelines are provided for standardization in study design and breath collection methods to improve comparability, avoid duplication of research and reduce discomfort of animals in future studies.

Methods
PubMed and Embase database were searched for animal studies using exhaled breath analysis to detect gastro-intestinal diseases. Risk of bias was assessed using the SYRCLE’s risk of bias tool for animal studies. Information on study design, standardization methods, animal models, breath collection methods and identified VOCs were extracted from the included studies.

Results
10 studies were included (acute liver failure n = 1, non-alcoholic steatohepatitis n = 1, hepatic ischemia n = 2, mesenteric ischemia n = 2, sepsis and peritonitis n = 3, colitis n = 1). Rats were used in most of the studies. Exhaled breath was mostly collected using invasive procedures as tracheal cannulation or tracheostomy. Poor reporting on standardization, breath collection methods, analytical techniques, as well as heterogeneity of the studies, complicate comparison of the different studies.

Conclusion
Poor reporting of essential methodological details impaired comprehensive summarizing the various studies on exhaled breath in gastrointestinal and hepatic diseases. Potential pitfalls in study design, and suggestions for improvement of study design are discussed which, when applied, lead to consistent and generalizable results and a reduction in the use of laboratory animals. Refining the methodological quality of animal studies has the potential to improve subsequent clinical trial design.
Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials
Authors: El-Hellani Ahmad , Hanna Elyana , Sharma Mehak , Blohowiak Reagan , Joseph Phillip , Eid Tore , Nadim Haleh , El-Hage Rachel , Salman Rola , Karaoghlanian Nareg , Adeniji Ayomipo , Salam Sally , Talih Farid , Elbejjani Martine , Breland Alison , Eissenberg Thomas , Shihadeh Alan , Baldassarri Stephen R. , Talih Soha 
Published: September 2023

Introduction
Electronic cigarette (EC) use has increased rapidly in the last decade, especially among youth. Regulating nicotine delivery from ECs could help curb youth uptake and leverage EC use in harm reduction yet is complicated by varying device and liquid variables that affect nicotine delivery. Nicotine flux, the nicotine emission rate, is a parameter that incorporates these variables and focuses on the performance rather than the design of an EC. Nicotine flux therefore could be a powerful regulatory tool if it is shown empirically to predict nicotine delivery and subjective effects related to dependence.

Methods and analysis
This project consists of two complementary clinical trials. In Trial I, we will examine the relationship between nicotine flux and the rate and dose of nicotine delivery from ECs, hence, impacting abuse liability. It will also examine the extent to which this relationship is mediated by nicotine form (i.e., freebase versus protonated). At Yale School of Medicine (YSM), study participants will puff EC devices under conditions that differ by flux and form, while arterial blood is sampled in high time resolution. In Trial II, we will assess the relationship between nicotine flux, form, and subjective effects. At the American University of Beirut (AUB), participants will use EC devices with varying nicotine fluxes and forms, while dependency measures, such as the urge to use ECs, nicotine craving, and withdrawal symptoms, will be assessed. We will also monitor puffing intensity and real-time exposure to toxicants.

Ethics and dissemination
The protocol of Trial I and Trial II was approved by YSM and AUB IRBs, respectively. We will disseminate study results through peer-reviewed publications and conference presentations.

Trial registration
NCT05706701 for Trial I and NCT05430334 for Trial II.