bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Properties of the Bangla Version of the Beck Depression Inventory‐II (BDI‐II) With University Students in Bangladesh: A Cross‐Sectional Study
Authors: Hasan Md. Torun , Khan Mozibul H. A. 
Published: January 2025

ABSTRACTBackground and AimsIn clinical practice and research, the Beck Depression Inventory‐II (BDI‐II) is one of the most frequently employed and consistent depression assessment instruments. Despite numerous international studies thoroughly establishing the psychometric properties of the BDI‐II, no notable study has validated the scale in Bangladesh, especially on the student sample as well as in nonclinical settings. Therefore, the current study was conducted with a view to assessing the psychometric properties of the Bangla version of the BDI‐II in a sample of undergraduate students in the cultural context of Bangladesh.MethodsThe sample consisted of 1128 undergraduate students (55.9% males) aged from 18 to 28 (M = 22.35, SD = 1.41) from the university of Rajshahi, Bangladesh. The factor structure of the BDI‐II was investigated through confirmatory factor analysis (CFA).ResultsThe CFA revealed that the hypothesized two‐factor model of the BDI‐II had an acceptable fit [χ2/df = 3.030, GFI = 0.957, TLI = 0.949, and CFI = 0.955, RMSEA = 0.042] in the current sample, which confirms the factorial validity of the Bangla version of the BDI‐II. Cronbach's α value (for total scale α = 0.90; for the cognitive‐affective factor α = 0.88; and for the somatic factor α = 0.73) assured high internal consistency. The concurrent validity of the BDI‐II was confirmed by the correlation with the Emotional Intelligence Scale (EIS) and the Brunel Mood Scale (BRUMS) in the expected direction.ConclusionThe findings of the study suggest that the Bangla version of the BDI‐II is a valid instrument for assessing depression among the student community in Bangladesh. This study will also be very beneficial to research on mental health problems in Bangladesh.
The Impact of Being Present During Resuscitation on Family Members: A Scoping Review Protocol
Authors: Rahmawati Ira , Page Tamara , Conlon Lisa , Donnelly Frank 
Published: January 2025

ABSTRACTBackground and AimsFamily members of patients who are undergoing resuscitation may experience complex psychological challenges, including anxiety, depression, or posttraumatic stress symptoms. Although several studies have identified positive experiences of family members who were given the option to be present during their loved one's resuscitation, the actual impact of family presence during resuscitation on family members remains elusive and needs to be explored comprehensively. This review aims to identify the impact of being present during the resuscitation event of adult patients in in‐hospital settings on family members.MethodsThe proposed review will utilize the JBI methodology for scoping reviews. This review will include literature from all study designs that are published in English with no date restrictions. The inclusion criteria include studies evaluating the impact on family members after witnessing the resuscitation of a loved one or being present at the hospital during the event. This review will include studies conducted in intrahospital settings, including emergency departments, critical care units, and in‐hospital wards. This study will also emphasize the influences of social, cultural, and spiritual factors on FPDR practices. A systematic search will be conducted across five databases and gray literature. These include PubMed, CINAHL (EBSCO), Embase, Emcare, and PsycINFO, ProQuest Database, Open Access Theses and Dissertations, and Google Scholar. Two independent reviewers will screen titles and abstracts and assess the full text of selected articles against inclusion criteria. Discussion with all reviewer team members will be held when disagreements arise between the reviewers at each review stage. Data will be analysed and presented according to The Preferred Reporting Items for Systematic reviews and Meta‐Analyses extension for Scoping Review.Scoping Review RegistrationThis scoping review protocol was registered with Open Science Framework (https://doi.org/10.17605/OSF.IO/U6AW8).
Evaluation of Aneurysm Cases Undergoing Surgery at a Tertiary Center in Iran: A 22‐year Retrospective Study
Authors: Ghoddusi Johari Hamed , Ranjbar Keivan , Kassaee Kimia , Hoseini Seyed Mohammadali , Shahriarirad Reza 
Published: January 2025

ABSTRACTBackground and AimsAn arterial aneurysm is characterized by a localized expansion of a blood vessel relative to its original dimensions. Specifically, an abdominal aortic aneurysm (AAA) is identified as an aortic diameter measuring at least one and a half times the standard diameter at the renal artery level, approximately equivalent to 2.0 cm. In this study, we aim to evaluate the prevalence of AAA, along with the clinical features, trend, and incidence of ruptured AAA among patients undergoing surgery in our center.MethodsThe database of patients operated in Namazi Hospital from 2000 to 2021 was retrieved and patients undergoing vascular surgeries due to aneurysm were reviewed. All data were analyzed with SPSS version 26.0.ResultsA total of 599 cases of aneurysm were operated, among which 334 were contributed to the aorta and included in our study. The average age of the participants was 69.6 (SD: 12.1, range 16–93) years and 161 (85.2%) were male. The majority of cases were in the 60 to 80 years age group (n = 205; 62.5%). There was a significant association between the age groups and the AAA rupture (p = 0.003), with the highest occurrence among the above 80 years age group (n = 37, 49.3%). Regarding the location of the aneurysm, 274 were located in the infrarenal and abdominal region, 21 in the thoracoabdominal region, and 12 in the thoracic region. Among the cases in our study, 112 were cases of ruptured aneurysms. Furthermore, the age of patients with ruptured aneurysm were significantly higher compared to non‐ruptured patients (71.8 vs. 68.5; p = 0.019).ConclusionWe observed an increase in the incidence of AAA surgeries in our center throughout the years, with the population growing towards younger population, while the incidence of rupture increasing towards older age groups.
Reducing Air‐Conditioning Load by Using an Insulating Material in Iraq as a Case Study (Experimental and Numerical)
Authors: Hasan Atif Ali , Al‐Bayati Omer Adil Zainal , Lafta Noor Samir , Khaleel Mahmood H. 
Published: January 2025

ABSTRACTThis paper has studied different types of walls using constant interior and exterior finishing materials (thermostone, 200‐mm thick (A); fired clay bricks, 240‐mm thick (B); hollow concrete blocks, 200‐mm thick (C); solid concrete blocks, 140‐mm thick (D); and limestone, 200‐mm thick (E)) due to the availability of many different types of building materials in Iraq and the lack of control over the best use to demonstrate how each of these materials affects a building's insulation to deliver the appropriate levels of comfort and achieve the greatest possible reduction in the electrical energy needed for air conditioning. A unique chamber was created for performing the actual trials on such walls in their natural environment, which was the climate of the city of Baghdad (zip code 10016, 33° N latitude, 44° E longitude). The tests have been done both in their current state of operation and with the addition of thermal insulation (60‐mm thick microfiber glass insulation material). The values for electricity consumption by a wall without insulation are 92, 121, 199, 148, and 138 kW/m2, in cases noted as A1, B1, C1, D1, and E1, respectively. However, when the insulator is used, the values become 58, 63, 51, 100, and 92 kW/m2 for the cases noted as A2, B2, C2, D2, and E2, respectively. The percentage reduction in electrical energy consumed by the air conditioner used within the room with and without thermal insulation has been recorded in the range of 50%–65% and 25%–60%, respectively. Depending on the model used, and compared with the traditional model, the saving difference with and without insulation was 15% and 35%, respectively. The best case is C2, because it has no effect on the room's interior area. Also, the cooling load was less than in other cases; it was 51 kW/m2 and had the highest building electrical savings, which are 65% when taking the wall in case C1 as a reference.
The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis
Authors: Chen Sirui , Zhang Ningning , Zhang Ruirui , Zhang Lan , Luo Dadong , Li Junqiang , Liu Yaqing , Wang Yunan , Duan Xinyue , Tian Xin , Wang Tiancheng 
Published: January 2025

AbstractThis study aimed to investigate the causal relationship between systemic lupus erythematosus (SLE) and juvenile myoclonic epilepsy (JME). Univariable and reverse Mendelian randomization (MR) analyses were performed to investigate the potential causal associations between SLE, systemic autoimmune disorders (SADs), and JME. Two‐step mediation MR analysis was further performed to explore indirect factors that may influence the relationship between SLE and JME. Summary data on SADs were extracted from the Integrative Epidemiology Unit Open genome‐wide association study database, and summary statistics for JME were acquired from the International League Against Epilepsy Consortium. The inverse‐variance weighted (IVW) method was used for primary analysis, supplemented by MR‐Egger and weighted median. In the univariable MR analysis, IVW results indicated a causal relationship between SLE and an increased risk of JME (odds ratio = 1.0030, 95% confidence interval, 1.0004–1.0057; p = 0.023). The subsequent mediation MR analysis showed that inflammatory cytokines may not be the mediating factors between SLE and JME, while the inverse MR analysis found no significant relationship. Our study indicated that genetic susceptibility to SLE was causally linked to JME. However, subsequent mediation analysis failed to identify the potential mediators that could influence this relationship. Moreover, evidence suggested that other SADs were not causally associated with JME. This study may provide guidance for screening risk factors for seizures and exploring potential treatments in SLE and JME, and even all SADs and JME.
Artificial intelligence‐driven change redefining radiology through interdisciplinary innovation
Authors: Huang Runqiu , Meng Xiaolin , Zhang Xiaoxuan , Luo Zhendong , Cao Lu , Feng Qianjin , Ma Guolin , Dong Di , Wang Yang 
Published: January 2025

AbstractArtificial intelligence (AI) is rapidly advancing, yet its applications in radiology remain relatively nascent. From a spatiotemporal perspective, this review examines the forces driving AI development and its integration with medicine and radiology, with a particular focus on advancements addressing major diseases that significantly threaten human health. Temporally, the advent of foundational model architectures, combined with the underlying drivers of AI development, is accelerating the progress of AI interventions and their practical applications. Spatially, the discussion explores the potential of evolving AI methodologies to strengthen interdisciplinary applications within medicine, emphasizing the integration of AI with the four critical points of the imaging process, as well as its application in disease management, including the emergence of commercial AI products. Additionally, the current utilization of deep learning is reviewed, and future advancements through multimodal foundation models and Generative Pre‐trained Transformer are anticipated.
Effectiveness of custom‐designed pointed laser light for teaching intraoral radiographic technique to undergraduate students: A comparative study
Authors: Veerabhadrappa Suresh Kandagal , Yadav Seema , Ganesh Nandan , Ghani Wan Maria Nabillah , Khairah Bt Ismail Ummul , Zamzuri Ahmad Termizi Bin 
Published: January 2025

AbstractObjectivesIntraoral periapical radiographic techniques are mandatory exercises taught to undergraduate students during their training. The key challenges encountered while teaching the bisecting angle technique (BAT) include correctly positioning the X‐ray cone and adjusting the central X‐ray beam to the tooth of interest. To address this, a custom‐designed pointed laser light (CDPLL) was fabricated and attached to the X‐ray cone. This study evaluated the effectiveness of CDPLL compared to conventional BAT in acquiring quality radiographs, reducing errors, and evaluating students' perceptions through a questionnaire.MethodsThird‐year Bachelor of Dental Surgery (BDS) students were divided into two groups of 26 each. Group 1 used Conventional BAT, while Group 2 employed Laser‐Assisted BAT on a mannequin. Both techniques were taught through theory and clinical demonstrations. Students took radiographs of incisors, canines, premolars, and molars of both jaws. Group 1 students then transitioned to Laser‐Assisted BAT and repeated the radiographs. Inter‐group and intra‐group comparisons of radiographic quality and errors were analyzed using Chi‐Square tests.ResultsGroup 2 produced more excellent (41.8%) and acceptable (47.6%) radiographs, with fewer unacceptable ones (10.6%) than Group 1 (p < 0.001). Transitioning from conventional BAT to Laser‐Assisted BAT in Group 1 led to significantly higher excellent (41.8%) and lower unacceptable (7.2%) radiographs (p < 0.001). Errors were significantly higher in Group 1 (81.5%) compared to Group 2 (59.5%) (p < 0.001). Common errors included cone cut and overlapping while foreshortening was the least frequent error. Over 80% of students felt CDPLL effectively guided the central X‐ray beam and expressed interest in using it in the future.ConclusionsThe CDPLL affixed to the X‐ray cone serves as an effective teaching tool for taking high‐quality radiographs, yielding a higher number of excellent and acceptable radiographs while minimizing repetition and errors. It also aids students in adjusting the X‐ray cone and central beam to the desired teeth.
Dependence of RF Sputtering Power on Structural and Electrical Properties of SnO2 Thin Films
Authors: Sajdeh Natasha , Terohid Seyed Ali Asghar , Asgary Somayeh , Pour Ghobad Behzadi 
Published: January 2025

ABSTRACTSnO2 thin films were deposited on Si substrates by radio frequency (RF) magnetron sputtering technique, and the effects of different sputtering power (60–90 W) on the structural, surface morphological, and electrical properties of the film were investigated with XRD, Raman, AFM, SEM, and fore point probe. The deposited SnO2 film at lower RF was amorphous, while well‐defined intense XRD signals at higher RF power indicated significant improvement in crystalline nature. Eg and A1g vibrating modes related to SnO2 were clearly observed in the Raman spectra. With the increasing RF sputtering power, the surface roughness of the films gradually increased while electrical resistivity revealed sharp decrease.
Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report
Authors: Yogakanthi Saiumaeswar , Phan Timothy , Flanagan Emma , Yang Linda , Basnayake Chamara , Thevathasan Iniyaval , Schulberg Julien 
Published: January 2025

ABSTRACTAcute severe ulcerative colitis (ASUC) in pregnancy poses a clinical challenge with significant risk to both mother and fetus. Anti‐TNF alpha therapy is known to be safe in pregnancy, however, data surrounding outcomes in ASUC is limited. In this report, we present the case of a pregnant patient of 10 weeks' gestation with ASUC successfully managed with intensified and accelerated infliximab therapy for a total dose of 35 mg/kg during a single admission. This case highlights the use of this therapeutic strategy, as a part of a multidisciplinary approach, to avoid the need for a high‐risk colectomy.
Synthesis and Characterization of Antibacterial Poly{2‐[(methacryloyloxy)ethyl]trimethylammonium Chloride}/Chitosan Semi‐Interpenetrating Networks for Papain Release
Authors: Ferreira Carolina Cruz , Schutz Guilherme Frey , Teixeira Lucas Novaes , Martinez Elizabeth Ferreira , Vieira Roniérik Pioli , Mei Lúcia Helena Innocentini 
Published: January 2025

AbstractAnnually, thousands of individuals suffer from skin injuries resulting from trauma, surgeries, or diabetes. Inadequate wound treatment can delay healing and increase the risk of severe infections. In this context, a promising synthetic polymer with potent antimicrobial properties, Poly{2‐[(methacryloyloxy)ethyl]trimethylammonium chloride} (PMETAC), is synthesized and crosslinked with N,N’‐Methylenebis(acrylamide) (BIS) in the presence of Chitosan (CH), a natural, biocompatible polysaccharide that promotes cell regeneration and provides additional beneficial properties. These semi‐interpenetrating (semi‐IPN) networks are chosen as a matrix for releasing papain, a proteolytic enzyme with healing and debridement properties. By integrating the properties of the materials, this study evaluates PMETAC‐based hydrogels with different CH concentrations (5%, 10%, and 25%) to understand their physicochemical and biological performance, including antibacterial activity and cytocompatibility. By incorporating 25% CH led to a 19% increase in pore size and a 48% increase in maximum pore volume compared to the control PMETAC hydrogel. Additionally, all formulations demonstrate ≈100% reduction of E. coli and S. aureus, showcasing their remarkable antibacterial efficacy. The inclusion of CH also significantly improves fibroblast viability, with 25% CH formulation standing out as the most promising candidate for multifunctional dressings, highlighting their potential in the treatment of hard‐to‐heal wounds in regenerative medicine.
Bis‐Naphthylacrylonitrile‐Based Supramolecular Artificial Light‐Harvesting System for White Light Emission
Authors: Li Menghang , Wang Ruixin , Xia Yang , Fu Yuan , Wu Lujie , Sun Guangping , Zhu Jinli , Tang Yanfeng , Yao Yong 
Published: January 2025

AbstractA novel aggregation‐induced emission (AIE)‐based artificial light‐harvesting system (LHS) is successfully assembled via the host‐guest interaction of bis‐naphthylacrylonitrile derivative (BND), water‐soluble pillar[5]arene (WP5), and sulforhodamine 101 (SR101). After host‐guest assembly, the formed WP5⊃BND complexes spontaneously self‐aggregated into WP5⊃BND nanoparticles (donors) and SR101 (acceptors) is introduced into WP5⊃BND to fabricate WP5⊃BND‐SR101 LHS. Through the investigation of energy transfer between donors and acceptors, the artificial light‐harvesting processes are certified in WP5⊃BND‐SR101 LHS and the absolute fluorescence quantum yields (Φf(abs)) are significantly improved from 8.9% (for WP5⊃BND) to 31.1% (for WP5⊃BND‐SR101), exhibiting the excellent light‐harvesting capabilities. Notably, by tuning the donor/acceptor (D:A) molar ratio to 250:1, a conspicuous white light emission (CIE coordinate is (0.32, 0.32)) is realized and the fluorescence quantum yield of white light emission (Φf(abs)WP5⊃BND‐SR101‐White) is 29.2%. Moreover, the antenna effect of white fluorescence emission (AEWP5⊃BND‐SR101‐White) can reach 36.2, which is higher than that of recent artificial LHSs in water environments, suggesting vast potential applications in aqueous LHSs.
A‐to‐I‐Edited miR‐1304‐3p Inhibits Glycolysis and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inactivating Wnt5a/ROR2 Signaling
Authors: Chen Peng , Zhou Hang , Yang Xian , Zheng Yuzhen , Chen Yujie , Wang Peiyuan , He Hao , Liu Shuoyan , Wang Feng 
Published: January 2025

ABSTRACTA‐to‐I RNA editing is a pervasive mechanism in the human genome that affects the regulation of gene expression and is closely associated with the pathogenesis of numerous diseases. This study elucidates the regulatory mechanism of A‐to‐I edited miR‐1304‐3p in esophageal squamous cell carcinoma (ESCC). Western blot, immunohistochemistry, and RT‐qPCR assays were employed to quantify protein and mRNA expression. Colony formation, Edu, wound healing, and Transwell assays were applied to determine miRNA function. Glycolysis was assessed using glucose uptake and lactate production assay. A dual‐luciferase reporter assay confirmed the downstream targets of miRNA, and a xenograft assay demonstrated the efficacy of the miRNA. The A‐to‐I RNA editing level of miR‐1304‐3p was observed to increase in KYSE180 and KYSE140 ESCC cells following ADAR1 treatment. Following A‐to‐I editing, the function of miR‐1304‐3p in ESCC progression underwent a reversal, shifting from carcinogenic to inhibitory. Wild‐type (WT) miR‐1304‐3p targets IRS1, whereas the edited version targets ROR2. The WT miR‐1304‐3p, but not the edited version, suppressed the expression and tumor‐suppressive effect of IRS1 in ESCC. Conversely, ROR2, a specific downstream target of the edited miR‐1304‐3p, acted as a tumor promoter in ESCC. Furthermore, A‐to‐I editing of miR‐1304‐3p can inhibit glycolysis and inactivate the Wnt5a/ROR2 signaling pathway in ESCC. A‐to‐I RNA editing alters the function of miR‐1304‐3p in ESCC by changing its target gene. The edited miR‐1304‐3p hinders the development of ESCC by inhibiting glycolysis and inactivating the Wnt5a/ROR2 signaling pathway.
Sorafenib Alters Interstitial Proton and Sodium Levels in the Tumor Microenvironment: A 1H/23Na Spectroscopic Imaging Study
Authors: Khan Muhammad H. , Walsh John J. , Kurdi Sara , Mishra Sandeep Kumar , Mihailović Jelena M. , Coman Daniel , Hyder Fahmeed 
Published: January 2025

ABSTRACTCellular metabolism is inextricably linked to transmembrane levels of proton (H+), sodium (Na+), and potassium (K+) ions. Although reduced sodium‐potassium pump (Na+‐K+ ATPase) activity in tumors directly disturbs transmembrane Na+ and K+ levels, this dysfunction is a result of upregulated aerobic glycolysis generating excessive cytosolic H+ (and lactate) which are extruded to acidify the interstitial space. These oncogene‐directed metabolic changes, affecting intracellular Na+ and H+, can be further exacerbated by upregulation of ion exchangers/transporters. As Na+/H+ imbalances impact tumor invasion, chromosomal rearrangements, proliferation rate, angiogenesis, and immune function, measuring interstitial H+ (H+o) or pH (pHo) and interstitial Na+ (Na+o) could provide unique insights into cancer hallmarks. We obtained proton (1H) and sodium (23Na) magnetic resonance spectroscopic imaging (MRSI) data to map pHo and Na+o in a human‐derived glioblastoma model (U87) in vivo with sorafenib (protein kinase inhibitor) treatment and a placebo. In U87 tumors, sorafenib slowed tumor growth compared to placebo and restored transmembrane H+ and Na+ levels. Placebo tumors maintained an interstitial space that was less salty and more acidic, similar to naive U87 tumors, implying a proliferative state. However, sorafenib‐treated tumors had interstitial space that became more salty and less acidic, comparable to normal tissue. Importantly, these interstitial ionic changes occurred prior to tumor growth changes. These results imply that glioblastoma therapies, which may perturb transmembrane ions by different mechanisms (e.g., ion pumping, exchange, and/or transport), can be tracked by merging 1H with 23Na MRSI to measure treatment effectiveness.