bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing agitation, de‐escalation, and physical restraint at a children's hospital
Authors: Dalton Evan M. , Worsley Diana , Krass Polina , Kovacs Brian , Raymond Kathleen , Feudtner Chris , Shea Judy A. , Doupnik Stephanie K. 
Published: July 2023

AbstractBackgroundChildren hospitalized in medical hospitals are at risk of agitation. Physical restraint may be used to maintain patient and staff safety during de‐escalation, but physical restraint use is associated with physical and psychological adverse events.ObjectiveWe sought to better understand which work system factors help clinicians prevent patient agitation, improve de‐escalation, and avoid physical restraint.Design, Setting, and ParticipantsWe used directed content analysis to extend the Systems Engineering Initiative for Patient Safety model to clinicians working with children at risk for agitation at a freestanding children's hospital.Intervention, Main Outcome, and MeasuresWe conducted semistructured interviews to examine how five clinician work system factors affected patient agitation, de‐escalation, and restraint: person, environment, tasks, technology and tools, and organization. Interviews were recorded, transcribed, and analyzed until saturation.ResultsForty clinicians participated in this study, including 21 nurses, 15 psychiatric technicians, 2 pediatric physicians, 1 psychologist, and 1 behavior analyst. Work system factors that contributed to patient agitation were medical tasks like vital signs and the hospital environment including bright lights and neighboring patients' noises. Supports that helped clinicians de‐escalate patients included adequate staffing and accessible toys and activities. Participants indicated that organizational factors were integral to team de‐escalation, drawing connections between units' teamwork and communication cultures and their likelihood of successful de‐escalation without the use of physical restraint.ConclusionClinicians perceived that medical tasks, hospital environmental factors, clinician attributes, and team communication influenced patients' agitation, de‐escalation, and physical restraint. These work system factors provide opportunities for future multi‐disciplinary interventions to reduce physical restraint use.
Gene therapy for aromatic L‐amino acid decarboxylase deficiency: Requirements for safe application and knowledge‐generating follow‐up
Authors: Roubertie Agathe , Opladen Thomas , Brennenstuhl Heiko , Kuseyri Hübschmann Oya , Flint Lisa , Willemsen Michel A. , Leuzzi Vincenzo , Cazorla Angels Garcia , Kurian Manju A. , François‐Heude Marie Céline , Hwu Paul , Zeev Bruria Ben , Kiening Karl , Roujeau Thomas , Pons Roser , Pearson Toni S. 
Published: July 2023

AbstractThe autosomal recessive defect of aromatic L‐amino acid decarboxylase (AADC) leads to a severe neurological disorder with manifestation in infancy due to a pronounced, combined deficiency of dopamine, serotonin and catecholamines. The success of conventional drug treatment is very limited, especially in patients with a severe phenotype. The development of an intracerebral AAV2‐based gene delivery targeting the putamen or substantia nigra started more than 10 years ago. Recently, the putaminally‐delivered construct, Eladocagene exuparvovec has been approved by the European Medicines Agency and by the British Medicines and Healthcare products Regulatory Agency. This now available gene therapy provides for the first time also for AADC deficiency (AADCD) a causal therapy, leading this disorder into a new therapeutic era. By using a standardized Delphi approach members of the International Working Group on Neurotransmitter related Disorders (iNTD) developed structural requirements and recommendations for the preparation, management and follow‐up of AADC deficiency patients who undergo gene therapy. This statement underlines the necessity of a framework for a quality‐assured application of AADCD gene therapy including Eladocagene exuparvovec. Treatment requires prehospital, inpatient and posthospital care by a multidisciplinary team in a specialized and qualified therapy center. Due to lack of data on long‐term outcomes and the comparative efficacy of alternative stereotactic procedures and brain target sites, a structured follow‐up plan and systematic documentation of outcomes in a suitable, industry‐independent registry study are necessary.
Ion transmission in an electrospray ionization‐mass spectrometry interface using an S‐lens
Authors: Yan Yihui , Schmitt Lucas , Khramchenkova Anastasiya , Lengyel Jozef 
Published: July 2023

AbstractWe present the design and performance of an in‐house built electrospray ionization‐mass spectrometry (ESI‐MS) interface equipped with an S‐lens ion guide. The ion source was designed specifically for our ion beam experiments to investigate the chemical reactivity and deposition of the clusters and nanoparticles. It includes standard ESI‐MS interface components, such as nanoelectrospray, ion transfer capillary, and the S‐lens. A custom design enables systematic optimization of all relevant factors influencing ion formation and transfer through the interface. By varying the ESI voltage and flow rate, we determined the optimal operating conditions for selected silica emitters. A comparison of the pulled silica emitters with different tip inner diameters reveals that the total ion current is highest for the largest tip, whereas a tip with the smallest diameter exhibited the highest transmission efficiency through the ESI‐MS interface. Ion transmission through the transfer capillary is strongly limited by its length, but the loss of ions can be reduced by increasing the capillary voltage and temperature. The S‐lens was characterized over a wide range of RF frequencies and amplitudes. Maximum ion current was detected at RF amplitudes greater than 50 V peak‐to‐peak (p/p) and frequencies above 750 kHz, with a stable ion transmission region of about 20%. A factor of 2.6 increase in total ion current is observed for 650 kHz as RF amplitudes reach 400 V p/p. Higher RF amplitudes also focus the ions into a narrow beam, which mitigates their losses when passing through the ion guide.
Dynamics of parainfluenza virus among hospitalized children with acute respiratory tract infection under two‐child policy and COVID‐19 pandemic in Hubei Province, China, 2014–2022
Authors: Yi Song , Zhang Shan‐Shan , Wang Xin‐Rui , Zhou Yiguo , Zhang Wan‐Xue , Du Juan , Hu Xing‐Wen , Lu Qing‐Bin 
Published: July 2023

AbstractTo analyze changes in the detection of parainfluenza virus (PIV) in children hospitalized with acute respiratory tract infection (ARTI) during 2014–2022 in Hubei Province, and explore the impact of the universal two‐child policy and the public health measures against COVID‐19 epidemic on the prevalence of PIV in China. The study was conducted at the Maternal and Child Health Hospital of Hubei Province. Children aged <18 years with ARTI admitted from January 2014 to June 2022 were enrolled. The infection of PIV was confirmed by the direct immunofluorescence method in nasopharyngeal specimens. Adjusted logistic regression models were used to analyze the influence of the universal two‐child policy implementation and public health measurements against COVID‐19 on PIV detection. Totally 75 128 inpatients meeting the criteria were enrolled in this study from January 2014 to June 2022 with an overall PIV positive rate of 5.5%. The epidemic seasons of PIV prevalence lagged substantially in 2020. A statistically significant higher positive rate of PIV was observed in 2017–2019 compared to that in 2014–2015 (6.12% vs 2.89%, risk ratio = 2.12, p < 0.001) after the implementation of the universal two‐child policy in 2016. A steep decline occurred in PIV positive rate during the COVID‐19 epidemic in 2020 (0.92% vs 6.92%, p < 0.001) and it rebounded during the regular epidemic prevention and control period in 2021–2022 (6.35%, p = 0.104). In Hubei Province, the implementation of the universal two‐child policy might have led to an increase of PIV prevalence, and public health measures during the COVID‐19 epidemic might have influenced the fluctuation in PIV detection since 2020.
Convolutional neural network allows amylose content prediction in yam (Dioscorea alata L.) flour using near infrared spectroscopy
Authors: Houngbo Mahugnon Ezékiel , Desfontaines Lucienne , Diman Jean‐Louis , Arnau Gemma , Mestres Christian , Davrieux Fabrice , Rouan Lauriane , Beurier Grégory , Marie‐Magdeleine Carine , Meghar Karima , Alamu Emmanuel Oladeji , Otegbayo Bolanle O , Cornet Denis 
Published: July 2023

AbstractBackgroundYam (Dioscorea alata L.) is the staple food of many populations in the intertropical zone, where it is grown. The lack of phenotyping methods for tuber quality has hindered the adoption of new genotypes from breeding programs. Recently, near‐infrared spectroscopy (NIRS) has been used as a reliable tool to characterize the chemical composition of the yam tuber. However, it failed to predict the amylose content, although this trait is strongly involved in the quality of the product.ResultsThis study used NIRS to predict the amylose content from 186 yam flour samples. Two calibration methods were developed and validated on an independent dataset: partial least squares (PLS) and convolutional neural networks (CNN). To evaluate final model performances, the coefficient of determination (R2), the root mean square error (RMSE), and the ratio of performance to deviation (RPD) were calculated using predictions on an independent validation dataset. The tested models showed contrasting performances (i.e., R2 of 0.72 and 0.89, RMSE of 1.33 and 0.81, RPD of 2.13 and 3.49 respectively, for the PLS and the CNN model).ConclusionAccording to the quality standard for NIRS model prediction used in food science, the PLS method proved unsuccessful (RPD < 3 and R2 < 0.8) for predicting amylose content from yam flour but the CNN model proved to be reliable and efficient method. With the application of deep learning methods, this study established the proof of concept that amylose content, a key driver of yam textural quality and acceptance, can be predicted accurately using NIRS as a high throughput phenotyping method. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Effect of moderate beer consumption (with and without ethanol) on cardiovascular health in postmenopausal women
Authors: Trius‐Soler Marta , Martínez‐Carrasco Pamela , Tresserra‐Rimbau Anna , Moreno Juan J. , Estruch Ramon , Lamuela‐Raventós Rosa M. 
Published: July 2023

AbstractBACKGROUNDThe main aim of this 2‐year non‐randomized parallel controlled clinical pilot trial was to evaluate the long‐term effect of a moderate daily intake of beer (with and without alcohol) on cardiovascular health in postmenopausal women. A total of 34 participants were grouped into three study arms: 16 were administered alcoholic beer, 6 consumed non‐alcoholic beer, and 12 were in the control group. Changes in glucose metabolism, lipid profile, liver enzymes, anthropometric measurements, body composition, and blood pressure variables were monitored. Data on medical history, diet, and exercise were collected, and gustatory capacities were determined.RESULTSModerate consumption of beer, both alcoholic and non‐alcoholic, seemed to have positive effects on biochemical indicators of cardiovascular health in postmenopausal women, with 660 mL day−1 of non‐alcoholic beer reducing low‐density lipoprotein cholesterol blood levels, and 330 mL day−1 of alcoholic beer increasing high‐density lipoprotein cholesterol. The evolution of changes in android and gynoid fat percentage and their ratio differed significantly between study groups, which was attributable to either the interventions or the disparity between groups regarding the time elapsed since menopause onset. Iso‐α‐acids recognition threshold could be involved in intervention group election, whereas the sensory phenotypes studied were not associated with alcohol drinking frequency.CONCLUSIONSModerate beer consumption was found to improve the lipid profile of postmenopausal women, although their effects in preventing cardiometabolic alterations deserve further research (trial registration number: ISRCTN13825020; https://doi.org/10.1186/ISRCTN13825020). © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Mandibular Osteoradionecrosis: Defining the Microbial Milieu and Antimicrobial Resistance at the Time of Rescue Flap Surgery
Authors: Arianpour Khashayar , Liu Sara W. , Ciolek Peter J. , Prendes Brandon L. , Fritz Michael A. 
Published: July 2023

ObjectiveTo report the microorganisms and their antibiotic sensitivity profile from tissue cultures and stains at the time of anterolateral thigh fascia lata (ALTFL) rescue flap for management of mandibular osteoradionecrosis (ORN).MethodsRetrospective chart review of patients who underwent ALTFL rescue flap for native mandibular ORN between 2011 and 2022.ResultsTwenty‐six cases comprising 24 patients (mean age 65.4 years, 65.4% male) with mandibular ORN from whom tissue cultures and gram stain were obtained at the time of ALTFL rescue flap. 57.7% grew bacterial species, while 34.6% grew fungal species. Multibacterial speciation was noted in 26.9% of cultures. A combination of bacterial and fungal growth was also seen in 15.4% of cases. All gram‐positive cocci (GPC) were pansensitive to antibiotics except for one case of Staphylococcus aureus, which was resistant to levofloxacin. Gram‐negative bacilli (GNB) species were isolated in 50.0% of cases. All fungal growth was due to Candida species. No growth was noted in 23.1% of cases. Multidrug resistance was noted in 53.8% of cases when GNB was isolated.ConclusionWe report 76.9% of our cases of mandibular ORN had microbial growth from tissue cultures obtained at the time of the ALTFL rescue flap. Fungal growth was noted in a substantial number of cases and should be obtained as a specimen when pursuing culture‐driven antibiotic therapy. Most GPCs were pansensitive to antibiotics, while GNBs were often the harbinger of multidrug resistant mandibular ORN.Level of Evidence4 Laryngoscope, 134:166–169, 2024
Research grants, research collaboration, and publication in predatory journals: Evidence from publications by Indonesian social scientists
Authors: Fahlevi Heru , Faradisa Fira , Dawood Rahmad 
Published: July 2023

AbstractThis study investigates the role of research funding and research collaboration in the potential for publication in predatory journals among Indonesian social science academia. A total of 2953 articles published by at least one Indonesian author in the social science field between 2010 and 2020 in Scopus‐indexed journals were collected. The SCImago quartiles of 2019 for the Scopus database and Beall's list of potential predatory journals 2021 were used to evaluate the quality and credibility of the publication outlets. Descriptive statistics and decision tree analysis were performed to classify and predict the quality and credibility of the publications. A contrast in the quality and credibility of publications was identified between research funded by Indonesian and foreign institutions. Research publications that were financially supported by Indonesian ministries and authored by a single author and/or via local and national collaboration were more likely to appear in lower‐ranked journals and predatory journals than publications funded by international sponsors and/or that involved foreign author(s)/international collaboration. This study therefore highlights the need for significant changes in monitoring and evaluation systems, timelines, and output targets of Indonesian government research grant schemes, alongside the enhanced involvement of foreign researchers and reviewers in the research funding schemes.
Super‐Resolved Bulk States of Photonic Crystals With Cathodoluminescence Microscopy
Authors: He Xiao , Liu Dong‐Lin , Dang Zhi‐Bo , Huang Yi‐jing , Liu Zhi‐xin , Zheng Li‐heng , Liu Zheng‐chang , Dai Yu‐chen , Fang Zhe‐yu 
Published: July 2023

AbstractProgress in photonic crystals (PhCs) enables the advanced manipulation of light propagation, leading to strong light–matter interactions and unconventional applications. To explore the physical nature and realize the precise and efficient control of position‐dependent light–matter interactions, the direct deep‐subwavelength characterization of PhC states is pivotal. Here, the super‐resolved visualization of bulk states in the z‐direction asymmetric dielectric PhC is realized by characterizing the radiative local density of optical states, including the etched hole area. An accelerating voltage scanning approach is proposed to selectively probe bulk states and substrates, elucidating the electron–matter interactions affected by the electron‐beam energy. The bulk state energy is demonstrated to be confined inside structure holes as shown by the cathodoluminescence intensity mappings of PhCs with different geometrical parameters, enabling the design of a silicon‐based high‐quality cavity in the visible range. This work provides a deep investigation of the depth‐dependent interaction between the electron beam and dielectric PhCs, promoting the characterization of PhC delocalized modes. The deep‐subwavelength detail of bulk state benefits the future nanoscale manipulation of light–matter interactions and the optimization of quantum emission devices.
Self‐adjointness of non‐semibounded covariant Schrödinger operators on Riemannian manifolds
Authors: Milatovic Ognjen 
Published: July 2023

AbstractIn the context of a geodesically complete Riemannian manifold M, we study the self‐adjointness of , where ∇ is a metric covariant derivative (with formal adjoint ) on a Hermitian vector bundle over M, and V is a locally square integrable section of such that the (fiberwise) norm of the “negative” part belongs to the local Kato class (or, more generally, local contractive Dynkin class). Instead of the lower semiboundedness hypothesis, we assume that there exists a number and a positive function q on M satisfying certain growth conditions, such that , the inequality being understood in the quadratic form sense over . In the first result, which pertains to the case , we use the elliptic equation method. In the second result, which pertains to the case , we use the hyperbolic equation method.
IL‐8 correlates with nonresponse to neoadjuvant nivolumab in HPV positive HNSCC via a potential extracellular vesicle miR‐146a mediated mechanism
Authors: Hill Brianna L. , Calder Alyssa N. , Flemming Joseph P. , Guo Yiyang , Gilmore Sydney L. , Trofa Melissa A. , Daniels Sean K. , Nielsen Torbjoern N. , Gleason Laura K. , Antysheva Zoya , Demina Ksenia , Kotlov Nikita , Davitt Christopher J. H. , Cognetti David M. , Prendergast George C. , Snook Adam E. , Johnson Jennifer M. , Kumar Gaurav , Linnenbach Alban J. , Martinez‐Outschoorn Ubaldo , South Andrew P. , Curry Joseph M. , Harshyne Larry A. , Luginbuhl Adam J. , Mahoney Mỹ G. 
Published: July 2023

AbstractTherapy using anti‐PD‐1 immune checkpoint inhibitors (ICI) has revolutionized the treatment of many cancers including head and neck squamous cell carcinomas (HNSCC), but only a fraction of patients respond. To better understand the molecular mechanisms driving resistance, we performed extensive analysis of plasma and tumor tissues before and after a 4‐week neoadjuvant trial in which HNSCC patients were treated with the anti‐PD‐1 inhibitor, nivolumab. Luminex cytokine analysis of patient plasma demonstrated that HPVpos nonresponders displayed high levels of the proinflammatory chemokine, interleukin‐8 (IL‐8), which decreased after ICI treatment, but remained higher than responders. miRNAseq analysis of tetraspanin‐enriched small extracellular vesicles (sEV) purified from plasma of HPVpos nonresponders demonstrated significantly lower levels of seven miRNAs that target IL‐8 including miR‐146a. Levels of the pro‐survival oncoprotein Dsg2, which has been to down‐regulate miR‐146a, are elevated with HPVpos tumors displaying higher levels than HPVneg tumors. Dsg2 levels decrease significantly following ICI in responders but not in nonresponders. In cultured HPVpos cells, restoration of miR‐146a by forced expression or treatment with miR‐146a‐loaded sEV, reduced IL‐8 level, blocked cell cycle progression, and promoted cell death. These findings identify Dsg2, miR‐146a, and IL‐8 as potential biomarkers for ICI response and suggest that the Dsg2/miR‐146a/IL‐8 signaling axis negatively impacts ICI treatment outcomes and could be targeted to improve ICI responsiveness in HPVpos HNSCC patients.
The HDAC2–MTA3 interaction induces nonsmall cell lung cancer cell migration and invasion by targeting c‐Myc and cyclin D1
Authors: Wang Bin , Shen Xiao‐yong , Pan Lin‐yue , Li Zheng , Chen Chun‐ji , Yao Yuan‐shan , Tang Dong‐fang , Gao Wen 
Published: July 2023

AbstractGenome‐wide association studies have identified numerous single‐nucleotide polymorphisms (SNPs) associated with lung cancer; however, the functions of histone deacetylase 2 (HDAC2) rs13213007 and HDAC2 in nonsmall cell lung cancer (NSCLC) remain unclear. Here we identified HDAC2 rs13213007 as a risk SNP and showed that HDAC2 was upregulated in both peripheral blood mononuclear cells (PBMCs) and NSCLC tissues with the rs13213007 A/A genotype compared with those with the rs13213007 G/G or G/A genotype. Patient clinical data indicated strong associations between rs13213007 genotype and N classification. Immunohistochemical staining confirmed that higher expression of HDAC2 was associated with NSCLC progression. Furthermore, we generated 293T cells with the rs13213007 A/A genotype using CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 gene editing. Chromatin immunoprecipitation sequencing followed by motif analysis showed that HDAC2 can bind to c‐Myc in rs13213007 A/A 293T cells. Cell Counting Kit‐8, colony formation, wound‐healing, and Transwell assays revealed that HDAC2 upregulates c‐Myc and cyclin D1 expression and promotes NSCLC cell proliferation, migration, and invasion. Co‐immunoprecipitation, quantitative reverse transcription–polymerase chain reaction, and western blot analysis assays showed that MTA3 interacts with HDAC2, decreases HDAC2 expression, and rescues the migration and invasion abilities of NSCLC cells. Taken together, these findings identify HDAC2 as a potential therapeutic biomarker in NSCLC.