bluuebunny/crossref_metadata_2025_split huggingface dataset:
Социально-экономические факторы риска развития послеродовой депрессии и послеродового посттравматического стрессового расстройства
Authors: Якупова Вера А. , Суарэз Анна Д. , Шрайбман Любовь А. 
Published: April 2023

Введение. Послеродовая депрессия и послеродовое посттравматическое стрессовое расстройство (ПТСР) являются распространенными расстройствами перинатального периода. Они серьезно снижают качество жизни матери, имеют долгосрочные последствия для ее психологического благополучия и развития ребенка. В настоящем исследовании впервые на российской выборке рассмотрены социально-экономические факторы риска послеродовой депрессии и ПТСР, а именно факторы экономического статуса семьи, места родов и формата родов. Методы. В исследовании приняли участие 2579 женщин возраста 18–43 лет, в течение 12 месяцев, предшествовавших опросу, родившие одного ребенка или нескольких детей. Депрессия оценивалась при помощи Эдинбургской шкалы послеродовой депрессии, послеродовое ПТСР – при помощи Городской Шкалы Травмы в родах. Кроме того, были собраны социально-демографические данные и данные о прошедших родах. Результаты. Были обнаружены статистически значимые различия в выраженности симптомов послеродовой депрессии (F = 13,678, p < 0,001) и послеродового ПТСР в зависимости от экономического статуса матери (F = 10,235, p < 0,001). Также выявлены значимые различия в выраженности симптомов послеродовой депрессии (F = 10,780, p < 0,001) и послеродового ПТСР (F = 10,410, p < 0,001) в зависимости от формата родов (по полису обязательного медицинского страхования, с заключением платного контракта с роддомом, домашние роды). Не выявлено различий в выраженности симптомов послеродовой депрессии и послеродового ПТСР в зависимости от места родов (сельская местность, поселок городского типа, город) (F = 0,021, p = 0,979, F = 0,685, p = 0,504 соответственно). Обсуждение результатов. Результаты работы согласуются с предыдущими исследованиями в России и других странах, указывая на значимость социально–экономических факторов в этиологии послеродовой депрессии и ПТСР. Разработка программ поддержки ментального здоровья женщин с низким экономическим статусом во время беременности, родов и послеродового периода может стать перспективным направлением профилактики послеродовой депрессии и ПТСР.
MicroRNA-mediated Regulation of LDL Receptor: Biological and
Pharmacological Implications
Authors: Keshavarz Reyhaneh , Reiner Željko , Zengin Gokhan , Eid Ali H. , Sahebkar Amirhossein 
Published: April 2023

Abstract:
One of the main causes of atherosclerosis is a disruption in cellular cholesterol
hemostasis. The low-density lipoprotein receptor (LDLR) is an important factor in maintaining
cholesterol homeostasis by the receptor-mediated endocytosis of LDL particles.
Defective hepatic LDLR activity and uptake of LDL particles lead to elevated blood levels
of low-density lipoprotein cholesterol (LDL-C), which is associated with a higher risk
of atherosclerotic cardiovascular disease. LDLR expression can be affected by microRNAs
(miRNAs). Some miRNAs, like miR-148a, miR-185, miR-224, miR-520,
miR-128-1, miR-27a/b, miR-130b, and miR-301 seem to be important post-transcriptional
regulators of LDLR related genes. These findings indicate the critical role of miRNAs
in regulating LDL metabolism. The aim of this review was to provide insight into the
miRNAs involved in LDLR activity and their potential roles in the treatment of cardiovascular
disease.
The Preventive Effect of Endostar on Radiation-induced Pulmonary Fibrosis
Authors: Ying Hangjie , Zhou Cheng , Hang Qingqing , Fang Min 
Published: April 2023

Background:
Radiation-induced pulmonary fibrosis (RIPF) is a long-term
complication of thoracic radiotherapy without effective treatment available.

Objective:
This study aimed to establish a RIPF mouse model and explore the
therapeutic effects and mechanisms of recombinant human endostatin (Endostar).

Methods:
C57BL/6 mice received a 16-Gy dose of X-rays to the whole thorax with or
without the administration of Endostar for 24 weeks.

Results:
Radiation-induced body weight loss was partially attenuated by Endostar
(P<0.05). Endostar significantly reduced alveolar inflammation (P<0.05) and pulmonary
fibrosis (P<0.001), as indicated by a decrease in the expression levels of collagen I and
collagen IV in lung tissue (both P<0.001). Angiogenesis (as shown by CD31
immunohistochemistry) was also decreased (P<0.01). In irradiated mice, Endostar
inhibited the transforming growth factor-β1 (TGF-β1)/drosophila mothers against the
decapentaplegic 3 (Smad3)/extracellular regulated protein kinases (ERK) signaling
pathway (all P<0.05). In vitro, Endostar treatment decreased the radiation-induced
expression of TGF-β1, vascular endothelial growth factor (VEGF), p-Smad3, and p-ERK
in alveolar epithelial cells and vascular endothelial cells (all P<0.05).

Conclusion:
Endostar could alleviate RIPF through decreased antiangiogenic activity
and inhibition of the TGF-β1/Smad3/ERK pathway.
Metabolomics to Study Human Aging: A Review
Authors: Martins Claudia , Magalhães Sandra , Almeida Idália , Neto Vanessa , Rebelo Sandra , Nunes Alexandra 
Published: April 2023

Abstract:
In the last years, with the increase in the average life expectancy, the world’s
population is progressively aging, which entails social, health and economic problems. In
this sense, the need to better understand the physiology of the aging process becomes
an urgent need. Since the study of aging in humans is challenging, cellular and animal
models are widely used as alternatives. Omics, namely metabolomics, have emerged in
the study of aging, with the aim of biomarker discovering, which may help to
uncomplicate this complex process. This paper aims to summarize different models
used for aging studies with their advantages and limitations. Also, this review gathers the
published articles referring to biomarkers of aging already discovered using
metabolomics approaches, comparing the results obtained in the different studies.
Finally, the most frequently used senescence biomarkers are described, along with their
importance in understanding aging.
Protective Effects of Ornithine on Hepatic Ischemia-reperfusion Injury
Authors: Singh Kuldeep , Kumar  Gupta Jeetendra , Singh Krishanveer , Kumar Shivendra 
Published: April 2023

Abstract:
Hepatic ischemia-reperfusion injury is a common complication of liver surgery and
transplantation. The morbidity related to hepatic surgery under a total vascular exclusion or following
liver transplantation is caused by ischemia-reperfusion damage. Numerous pathways are involved
in the pathophysiology of hepatic ischemia-reperfusion, and they all play a role in the overall
injury to varying degrees. Post-surgical hepatic dysfunction is one of the primary causes of morbidity
and mortality. Several studies have suggested oxidative stress, inflammation, mitochondrial
dysfunction, activation of the liver Kupffer cell, overexpression of Vascular Cell Adhesion Molecule,
and facilitation of (PMN) polymorphonuclear neutrophil damage are involved in the pathophysiology
of ischemia-reperfusion damage in the liver. Ornithine is an amino acid and non-proteinogenic
in nature. It plays a vital role in the urea cycle. Ornithine is commonly present in dietary
supplements that have been proven to influence the hepatic ischemia-reperfusion injury-linked
pathways, hence lowering deterioration in the liver ischemia/reperfusion dysfunction. Liver cirrhosis
has been treated using a stable salt of ornithine and aspartic acid. After surgical tumour removal,
patients who take ornithine aspartate may experience less hepatic ischemia-reperfusion damage. Lornithine
functions as a precursor to citrulline and arginine and enables the elimination of extra
nitrogen. Ischemia/reperfusion injury is caused by the aggravation of cellular upsets and mortality
following the refurbishment of blood flow to the earlier ischemic tissue. This article confers a deep
understanding of the protective effects of ornithine on hepatic ischemia/reperfusion injury as well
as evidence linking ornithine's function tending towards the detoxification mechanism of the liver.
Salibu Rice Cultivation in Tungro Endemis Region
Authors: Hafid Khaerana , Widiarta I Nyoman , Gunawan Achmad , Muazam Arif 
Published: April 2023

Salibu is modified ratoon rice which has advantages in economic and time-saving. Tungro disease is one of probable handicap for salibu to be controlled in their endemic area. Rice virus tungro disease is caused by Rice Tungro Bacilliform Virus (RTBV) and Rice Tungro Spherical Virus (RTSV) which are transmitted by leafhopper. The research goals are to know the growth of leafhopper population and the spread of the tungro disease in salibu and conventional rice farming system as well as their effect on yield. The research was conducted in split plot experiment and designed in a randomized block design. The main plot were 1) salibu system and 2) conventional system (non-salibu). The subplots were varieties 1) TN1 (sensitive variety), 2) Ciherang (commonly used by the farmer), and 3) Inpari 36 (tungro new resistant variety). The results revealed that the tungro attack rate, dry milled grain yield, and 1000 dry grain weight were significantly higher in conventional cultivation than salibu (P < 0.05). The number of leafhopper populations tended to be higher in salibu system than in conventional system. The number of natural enemies did not show a particular pattern related to green leafhopper's presence. The Shannon Wiener diversity index for natural enemies ranged from low to medium. Regarding to the results, salibu system is not recommended yet in the tungro endemic areas. Keywords: Salibu, rice tungro virus disease, green leafhopper, natural enemies
Axiosphere of Social Advertising Poster about Coronavirus in Russia and China
Authors: Vepreva I. T. , Yang Zhibing 
Published: April 2023

The axiogenic situation of the pandemic is considered based on the material of social advertising of two countries — Russia and China. The thesis is advanced that the coronavirus pandemic can be considered as a referent that allows a value-marked interpretation. The purpose of the work is to identify a set of universal values objectified in social advertising; characterize verbal and visual codes as means of expressing valuable meanings; determine national specifics of advertising.400 Russian and Chinese advertising texts served as the material for the observations. As a result of the analysis, it was revealed that the axiological space of advertising of both countries is constructed by a set of valuable meanings, united by the absolute value of being — the concept of LIFE. It is noted that the structure of advertising discourse is based on the dichotomy of biological and social. The key value, along with life and its protection, was the strength of unity and cohesion of the nation in the face of a mortal threat. The value of the heroic is objectified in the image of medical workers. It was revealed that Chinese advertising is characterized by a language game associated with homonymy and the transformation of phraseological units, and the absence of weakly creolized texts with a strong cultural and historical component of the visual series. It is concluded that Russian advertising revives the style of the Soviet poster when promoting sanitary and hygienic rules.
6. Stylistic and Technical Orientations in Romanian Creation for Clarinet of the Twentieth Century
Authors: Paicu Daniel 
Published: April 2023

Abstract
A controversial period in humanity’s evolution is the previous century, the 20th, viewed both from a constructive and a destructive point of view. Technical progress and scientific discoveries led the human dimension towards a huge leap of civilization. But this computerized trajectory holds unlimited possibilities in creating balance or chaos within the human. The multiple effects of modern technology on human life can affect, even completely change, interpersonal communication. In the thinking of Romanian composers, especially in the second half of the 20th century, new concepts and working techniques are designed. Among these, we mention dodecaphonic serialism, integral serialism, heterophony, rhythm with added values, texture, aleatoric, etc., all leading to a totally new, experimental acceptance.
7. Musical Education in the Family. Challenges and Fulfillments in the Parent-Teacher Role
Authors: Fărcăşel Ligia 
Published: April 2023

Abstract
The role of parent is in itself one that provides both challenges and fulfilments. Moreover, it necessarily assumes the exercise of the pedagogical function. The main challenge is the delimitation between the position of a teacher and that of a parent, implicitly that of a student and that of a child. At the same time, the fulfillment that covers both the didactic process and the result, is the ultimate reward and also the motivation for starting another project. The present case study covers a period of approximately two years, involving the teacher-parent (mother) aged approximately 30 years and the student-child (girl) aged 5-7 years. The three completed or ongoing projects aim, on the one hand, at learning the basics of piano and ukulele performance and, on the other hand, at the vocal performance of a pop piece in a festival-competition.
9. The Holistic Approach to Music Education Throughout the Life Course: News and Perspectives
Authors: Cosumov Marina 
Published: April 2023

Abstract
Music, constituting a great phenomenon of the world, represents an inherent element in the daily life of society, in the consciousness and nature of man, because everything is movement, everything is vibration, everything is sound. The relationship “man-music (arts)” places in the foreground the educational function through which it - educates moral feelings, human qualities, cultivates the spiritual sphere of man. Musical education throughout life is presented as a continuous individual process of spiritual self-improvement of the personality through multiple forms of relationship with the art of music. In this context, musical education is significant to perpetuity - lifelong education, on the three dimensions of the human being: biological, intellectual, spiritual, because it is implicitly based on the undulating character of the universe, the cosmos and human existence.
10. The Influence of Eusebie Mandicevschi on the Formation of the Personality of the Composer Marţian Negrea
Authors: Acatrini Vladimir , Vovk Myroslava , Filipchuk Nataliia 
Published: April 2023

Abstract
The composer, choir conductor and musicologist, raised from the lands of Bucovina. Eusebie Mandicevschi (1857 - 1829) left posterity a complex musical work: vocal, symphonic, chamber, choral music, prestigious critical studies on Johann Sebastian Bach, Ludwig van Beethoven, Joseph Haydn, Franz Schubert, Johannes Brahms, distinguishing himself, throughout his life, through a sustained and competent pedagogical activity, through a prodigious social activity he was a teacher at the “Akademie für Musik und darstellende Kunst” in Vienna, as an archivist and librarian at the “Gesellschaft der Musikfreunde” in Vienna.
1. Formal and Non-Formal Education Through Theatre54
Authors: Kušnírová Eva 
Published: April 2023

Abstract
The Frankfurt Declaration is a UNESCO document that reminds and re-emphasizes the importance of promoting and applying arts education to the curriculum of all member states. In 2019, the World Alliance for Arts Education (WAAE) organized an international conference called Arts Education for everybody? Every student? Everywhere? It opened a discussion on various topics about arts education (e.g., in society, in school reforms, opportunities for the education of pedagogues, interconnection with other fields, its application at different levels of schools, its future, possibilities to spread and communicate it in different countries of the world). The education through theatre also belongs to the field of arts education. The study reflects and maps the topic of formal and non-formal education through theater. It ponders the question What is the status of formal and non-formal education through theater nowadays? It points to interesting and inspiring projects, to institutions dedicated to the education through theatre, to the educational activities of professional cultural institutions, the position of drama education in the school system and beyond it, the education through theater at universities, as part of festivals, etc. It also brings an excursion into the education through theater in abroad, in the Czech Republic and Slovakia.
4. The Inner Mechanism of the Actor in the Vision of Eugenio Barba
Authors: Moraru Iuliana 
Published: April 2023

Abstract
The discoveries he makes in his journey around the world, the admiration for the way Grotowski thinks and for Brecht’s theories, but also the history of the years 1960-1978 stir up Eugenio Barba, causing him to look for new meanings related to this art. After going through a period of disorientation and hearing around him from many people the question: what is the meaning of doing theater today?, he finds the answer: “theatre is an empty and ineffective ritual that we fill with our own why, with our personal necessity”. Barba praises the modesty and strength of the actor who considers himself the servant of the stage and not the “navel of the crowd” that surrounds him. The concepts of yoga lead him to write about the “body-spirit” and how essential it is for a performer to exercise his spirit.
5. A Possible Way of Approaching the Character in the Theater According to the “Role Sheet”
Authors: Chirilă Călin 
Published: April 2023

Abstract
“Match the deed with the word, and the word with the deed. Take care not to exceed the decency and modesty of nature; because everything that exceeds the measure deviates from the goals of the theater, whose purpose from the very beginning and until today is to present a kind of mirror of nature, to show virtue its true face, pride its icon and every age, every era, the pattern and their seal” (Hamlet’s monologue from the play of the same name by W.Shakespeare).
9. Digital Technologies - The Future Way of Learning in Higher Education
Authors: Aliu Nora , Aliu Vlora , Gashi Modest 
Published: April 2023

AbstractDigitalization trends have moved forward with accelerated steps, surrounding all spheres of our lives with the provision of light services, faster and less expensive communications, more functions, and a great influence on increasing quality of life. In developed countries, digitization of education is seen as one of the priority goals for achieving sustainable development. Higher education is an essential pillar in developing new knowledge economies for the twenty-first century, and Kosovo national authorities are strategically oriented toward the digitalization of higher education. Digitization includes a wide range of activities ranging from lecturers, group work lectures, and inclusion in individual or group study, and exams as an integral part of the revolutionization of higher education. The period of COVID19 has pushed forward the digitization of education in many countries of the world. In Kosovo, this was the period that established the dividing boundaries between the traditional multi-century teaching eras with the new digital era. This period is also characterized by the challenges faced by teaching and learning in the use of efficient digitized methods. This paper explores the impact of digitization on teaching and learning, specifically in medicine and architecture. Also, this work is intended to offer a model of how digital transformation can be used to build competitive advantages for universities. Based on the condition of the accreditation agency and the standards of the International Society for Technology in Education, we can say that the use of software and artistic methods in teaching processes affects the development and advancement of young people.
Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study
Authors: Srinivas Sahana M , Dhar Sandipan , Gowdra Aruna , Saha Abhijit , Sundararajan Lakshmi , Geetha Thenral S , Banerjee Raghubir , Malakar Rajib , Sil Amrita , Lakshminarayana Shyam Prasad Arakali 
Published: April 2023

Background
Filaggrin (FLG) gene encoding the protein filaggrin plays an important role in barrier function of the skin and its alteration is a predisposing factor for atopic dermatitis. FLG gene variants result in absent or decreased filaggrin protein. Worldwide, the prevalence of FLG variants ranges from 14 to 56%. FLG null variants are distinct in each population.

Objectives
To study the FLG gene polymorphisms in Indian children and attempt a genotype-phenotype correlation in atopic dermatitis.

Methods
This was a cross-sectional, multicentre study conducted on 75 Indian children. Demographic details, clinical features and identified FLG null variants were recorded. We performed a whole gene sequencing of the entire FLG coding region using next-generation sequencing technology.

Results
The prevalence of FLG null variants was 34.7%. A total of 20 different FLG loss of function variants in 26 children were documented. Sixteen (80%) variants were novel and four (20%) were previously reported in Asian and European populations. We found a statistically significant association between FLG variants with early age of onset of atopic dermatitis (P = 0.016) and elevated serum IgE levels (P = 0.051). There was no significant difference between atopic dermatitis phenotypes in children having one variant as compared to children harbouring two or more null variants.

Limitation
Small sample size.

Conclusion
Our study reports a unique set of FLG variants different from Asian and European populations, with these variants being significantly associated with an early age of onset of atopic dermatitis and elevated serum IgE levels.
PENGARUH VARIASI KONSENTRASI HPMC TERHADAP KUALITAS MUTU SEDIAAN FACIAL WASH GEL NANOPERAK HASIL BIOSINTESIS EKSTRAK BUAH PEPAYA (Carica papaya L.)
Authors: Hasriyani Hasriyani , Presticasari Hardiyani , P Novam Danu , Mundriyastutik Yayuk 
Published: April 2023

AbstrakBuah pepaya (Carica papaya L.) mengandung banyak senyawa flavonoid yang dapat mensintesis perak menjadi nanoperak. AgNP (nanoperak) diketahui memiliki aktivitas sebagai antibakteri pada jerawat. AgNP kemudian diformulasikan ke dalam sediaan Facial Wash gel dengan 3 variasi konsentrasi HPMC kemudian dilakukan uji mutu sediaan meliputi organoleptis, pH, viskositas, daya sebar, dan daya lekat. Sediaan disimpan selama 14 hari di suhu ruang untuk mengetahui pengaruh dari waktu penyimpanannya.Tujuan dari penelitian ini adalah untuk mengetahui pengaruh variasi HPMC dan mengetahui kualitas mutu dari sediaan facial wash gel nanoperak.Jenis penelitian merupakan penelitian true experimental yang menghasilkan data kualitatif dan kuantitatif. Analisis kualitatif berdasarkan penelitian-penelitian terdahulu yang termuat dalam pustaka dan analisis kuantitatif dilakukan dengan metode statistik Two Way Anova (α = 0.05) serta analisis Post-Hoc dengan uji Tukey. Terdapat pengaruh akibat perbedaan HPMC yang digunakan pada 3 formula yaitu Formula 1 (2% HPMC), Formula 2 (3% HPMC), dan Formula 3 (4% HPMC) terhadap kualitas mutu sediaan berdasarkan uji organoleptis, uji pH, uji viskositas, uji daya sebar, dan uji daya lekat. Pada Formula 1 tidak dapat memenuhi kriteria daya lekat yang baik, sedangkan pada Formula 2 dan 3 memenuhi kriteria syarat sediaan facial wash yang baik.Hasil penelitian menunjukkan bahwa ada hubungan antara pengaruh dari variasi konsentrasi HPMC terhadap kualitas mutu sediaan facial wash gel tetapi pengaruh dari waktu penyimpanan selama 14 hari tidak mempengaruhi kualitas mutu sediaan. Kata Kunci : Carica papaya L., Nanoperak, Facial Wash.