bluuebunny/crossref_metadata_2025_split huggingface dataset:
STandards for Reporting Interventions in Clinical Trials Of Tuina/Massage (STRICTOTM): Extending the CONSORT statement
Authors: Zhang Xuan , Liang Feng , Lau Chung Tai , Chan Jacky CP , Wang Nana , Deng Jiashuai , Wang Juan , Ma Yanfang , Zhong Linda L. D. , Zhao Chen , Yao Liang , Wu Taixiang , Lyu Aiping , Tian Guihua , Shang Hongcai , Miao Jiangxia , Bian Zhaoxiang ,   STRICTOTM Working Group
Published: March 2023

AbstractObjectivesMassage is a common therapy of nonpharmacological treatments, particularly in Tuina (Chinese massage) as its most common style, detailed guidance in reporting the intervention is warranted for its evaluation and replication. Based on the CONSORT (Consolidated Standards of Reporting Trials), we aimed to develop an Extension for Tuina/Massage, namely “The STandards for Reporting Interventions in Clinical Trials Of Tuina/Massage (STRICTOTM).”MethodsA group of professional clinicians, trialists, methodologists, developers of reporting guidelines, epidemiologists, statisticians, and editors has developed this STRICTOTM checklist through a standard methodology process recommended by the EQUATOR (Enhancing the QUAlity and Transparency of Health Research) Network, including prospective registration, literature review, draft of the initial items, three rounds of the Delphi survey, consensus meeting, pilot test, and finalization of the guideline.ResultsA checklist of seven items (namely Tuina/Massage rationale, details of Tuina/Massage, intervention regimen, other components of the intervention, Tuina/Massage provider background, control or comparator interventions, and precaution measures), and 16 subitems were developed. Explanations and examples (E&E) for each item are also provided.ConclusionsThe working group hopes that the STRICTOTM, in conjunction with both the CONSORT statement and extension for nonpharmacologic treatment, can improve the reporting quality and transparency of Tuina/Massage clinical research.
Analysis of damage caused by drop impacts for mulberry fruits: An dropping experiment and numerical simulation
Authors: Hou Junming , Zhu Ziang , Hu Weixue , He Zhenhu , Sun Qijie , Yue Xiang 
Published: March 2023

AbstractIn the process of mechanized production of mulberry, falling collision damage is one of the main damage forms, which causes serious damage and accelerates fruit decay. Through the drop collision test and simulation analysis of mulberry fruit, the relationship between drop conditions and fruit damage degree was established, so as to provide reference for reducing fruit falling damage. The drop test is carried out. The relationship between factors and indicators is established. The drop height, fruit plate angle, fruit plate material, and drop direction were taken as factors, and then the energy loss was selected as indicator. The drop process of mulberry fruit is analyzed by numerical simulation, and the maximum stress and deformation of mulberry fruit are analyzed. With the increase of the drop height, the kinetic energy of the fruit increases. When the fruit plate material is pearl cotton, the drop height changes from 200 to 1000 mm, the energy loss of fruit falling increases from 4.42 × 10−0.3 J to 2.14 × 10−0.2 J. When the drop height of fruit is 200 mm, the angle of fruit plate is 30°, and the material of fruit plate is pearl cotton, the minimum energy loss of fruit is 3.39 × 10−0.3 J, the fruit damage was the least. This study can provide a reference to reduce the damage of mulberry fruit in the process of mechanical harvest and transportation.Practical ApplicationsThe existing mulberry harvesting methods are manual harvesting, while the vibration harvesting methods have high harvesting efficiency and serious damage. When the harvesting parts hit the tree trunk, the mulberry fruit will leave the tree and falls onto the fruit‐receiving device in the process of mechanical harvesting. There will be a collision and falling of the mulberry, which may cause serious damage. Therefore, in the process of mulberry fruit harvest, transportation, the falling, and collision damage is the main damage form.At present, there is few research on the drop impact damage test of mulberry fruit. In this study, the effects of mulberry falling direction, fruit plate material and drop height on mulberry damage were discussed by drop experiment. Then, the optimization results were carried out. The change and distribution of stress and strain in the process of collision were analyzed by numerical simulation, and the relationship between falling conditions and damage level was established. It is important to analyze the dynamic characteristics of mulberry in the process of drop. This study can be applied as a reference to reduce mulberry fruit impact damage, and provide a theoretical reference for the design of mulberry vibration harvesting machinery.
Possible biological mechanisms of entecavir versus tenofovir disoproxil fumarate on reducing the risk of hepatocellular carcinoma
Authors: Murata Kazumoto , Mizokami Masashi 
Published: March 2023

AbstractHepatitis B virus (HBV) is a life‐threatening infectious virus associated with the risk of liver failure and hepatocellular carcinoma (HCC). Regarding HBV treatment, the recent development of nucleoside/nucleotide analogs (NUC), HBV reverse transcriptase inhibitors, enabled favorable viral control as well as improved prognosis in patients with chronic hepatitis B. However, NUC fails to clear HBV because the formation of covalently closed circular DNA or HBV surface antigen occurs upstream of the point of action of NUC. Recently, we found that acyclic nucleoside phosphonates (ANP) such as adefovir or tenofovir, but not lamivudine or entecavir, induced IFN‐λ3 productions in the gastrointestinal tract and modulated lipopolysaccharide (LPS)‐mediated cytokine profiles in peripheral blood mononuclear cells, such as interleukin (IL)‐12p70 induction and IL‐10 inhibition, which are immunologically favorable cytokine profiles for HBV elimination. Furthermore, IFN‐α, in combination with ANP, showed additional and synergistic effects on IFN‐λ3 and IL‐12p70 production, respectively, while not affecting IL‐10 levels. Mechanistic analyses of the cytokine modulation by ANP revealed that ANP blocked the mammalian target of the rapamycin (mTOR) pathway by inhibiting Akt translocation to the plasma membrane, thereby inhibiting Akt phosphorylation. As it has been reported that IFN‐λ inhibits tumor growth directly or indirectly and the mTOR pathway is generally activated in most cancer cells, ANP might have potential anti‐HCC effects. Our in vitro and ex vivo findings might stir the debate on whether types of NUC affect the risk of HBV‐related HCC incidence.
Role of rifaximin in the management of alcohol‐associated hepatitis: A systematic review and meta‐analysis
Authors: Ahmed Zohaib , Badal Joyce , Nawras Mohamad , Battepati Dhanushya , Farooq Umer , Arif Syeda Faiza , Lee‐Smith Wade , Aziz Muhammad , Iqbal Umair , Nawaz Ahmad , Gangwani Manesh Kumar , Iqbal Amna , Kobeissy Abdallah , Addissie Benyam D , Hassan Mona , Saab Sammy 
Published: March 2023

AbstractBackground and AimAlcohol‐associated hepatitis (AAH) is an acute, inflammatory liver disease with severe short‐term and long‐term morbidity and mortality. AAH can lead to severe complications including hepatic failure, gastrointestinal bleeding, sepsis, and the development or decompensation of cirrhosis. Rifaximin is an antibiotic that reduces bacterial overgrowth and gut translocation, and it may have a role in decreasing systemic inflammation and infection in patients with AAH. Therefore, we conducted a systematic review and meta‐analysis to evaluate the role of rifaximin in the management of AAH.MethodsA comprehensive search strategy was used to identify studies that met our inclusion criteria in Embase, MEDLINE (PubMed), Cochrane Library, Web of Science Core Collection, and Google Scholar. Outcomes of interest included rates of infection, 90‐day mortality, and overall mortality between the rifaximin versus non‐rifaximin group. Open Meta Analyst software was used to compute the results.ResultsThree studies with a total of 162 patients were included in the final meta‐analysis. Of the three studies, two were randomized control trials (RCTs), and one was a case–control study. There was a significantly lower rate of infection in the rifaximin group versus the non‐rifaximin group (RR: 0.331, 95% CI: 0.159–0.689, I2 = 0%, P = 0.003). There was no significant difference in 90‐day mortality in the rifaximin versus non‐rifaximin group (RR: 0.743, 95% CI: 0.298–1.850, I2 = 24%, P = 0.523), nor was there a significant difference in overall mortality (RR: 0.624, 95% 95% CI: 0.299–1.3, I2 = 7.1%, P = 0.208).ConclusionsThe use of rifaximin in AAH is associated with a lower rate of infection rate than the non‐rifaximin group. Additional research is needed to determine whether this effect is more pronounced in patients concurrently being treated with prednisolone. Differences in 90‐day or overall mortality did not reach statistical significance. Further studies, particularly large randomized controlled trials, are needed to establish the role of rifaximin in AAH, especially as an adjunct therapy with prednisolone.
Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study
Authors: Teng Xiaohui , Kang Shan , Li Weili , Ding Hongmei , Ling Bin , Zhu Lin , Wang Danbo , Lang Jinghe , Liu Ping , Chen Chunlin 
Published: March 2023

AbstractObjectiveWe aimed to compare the 5‐year oncological outcomes of laparoscopic/abdominal radical hysterectomy (LRH/ARH) in patients with cervical adenosquamous carcinoma at stage IA2 to IIA2 based on the 2009 or 2018 International Federation of Gynecology and Obstetrics (FIGO) staging criteria.MethodsBased on the clinical diagnosis and treatment of cervical cancer in China (Four C) database, Cox risk regression models were applied to analyze tumor prognosis treated with ARH/LRH in FIGO 2009 and 2018 IA2‐IIA2 patients and stratified findings according to tumor diameter (≤4 and >4 cm subgroups). And to avoid bias, propensity score matching (PSM) was also used for the cohort study.ResultsBased on FIGO 2009 staging criteria (n = 474), there was no significant difference between the ARH and LRH groups in 5‐year disease‐free survival (DFS) or overall survival (OS). Lymph node metastasis was a risk factor for 5‐year DFS in this stage. After PSM, lymphovascular space invasion (LVSI) was an independent risk factor for 5‐year OS in the tumors ≤4 cm subgroup. Based on FIGO2018 staging criteria (n = 322), cervical interstitial infiltration depth was an independent risk factor for 5‐year OS in the total population and the tumor diameter ≤4 cm subgroup.ConclusionsLaparoscopic surgery was not a risk factor affecting the oncologic prognosis of adenosquamous carcinoma of the cervix based on either FIGO 2009 or 2018 staging of stage IA2‐IIA2. In addition, LRH may be considered for patients with early‐stage cervical adenosquamous carcinoma.
Assessment of masticatory performance in patients undergoing orthognathic surgery: A systematic review and meta‐analysis
Authors: Bunpu Pokchat , Changsiripun Chidsanu 
Published: March 2023

AbstractBackgroundOne of the main goals of orthognathic surgery is to improve the masticatory performance in patients with maxillofacial deformities.ObjectiveThe aim of this study was to evaluate the literature on assessing masticatory performance before, after orthognathic surgery and normal occlusion.MethodsAn electronic search was performed via Pubmed, Scopus, LILACs and Web of Science without any restrictions until June 2022. The articles assessing masticatory performance using a comminution assay, bite force or occlusal contact area in patients undergoing orthognathic surgery with or without comparing controls were included. The risk of bias of the selected articles was assessed using the appropriate tools according to the study design.ResultsOf the 2507 records identified, 21 studies were included in the qualitative evaluation and 17 studies in the meta‐analysis. Nine articles were cohort studies, and the other eight were before–after studies. Moderate to high risks of bias were found among the articles. Comparing the values before and after surgery, the meta‐analysis revealed a significant improvement in the bite force and occlusal contact area at 1‐ and 2‐year post‐surgery. However, regardless of the assessed parameters, the masticatory performance in patients with normal occlusion was significantly greater than those in patients undergoing orthognathic surgery at all evaluated time points.ConclusionAlthough combined surgical orthodontic treatment can improve impaired masticatory function, assessed by the comminution method, bite force and occlusal contact area, the improvement may not reach that of normal occlusion.
Molecular insights into Escherichia coli Cpx envelope stress response activation by the sensor lipoprotein NlpE
Authors: Marotta Julianna , May Kerrie L. , Bae Christina Y. , Grabowicz Marcin 
Published: March 2023

AbstractBacterial two‐component signal transduction systems provide sensory inputs for appropriately adapting gene expression. These systems rely on a histidine kinase that phosphorylates a response regulator which alters gene expression. Several two‐component systems include additional sensory components that can activate the histidine kinase. In Escherichia coli, the lipoprotein NlpE was identified as a sensor for the Cpx cell envelope stress response. It has remained unclear how NlpE signals to Cpx in the periplasm. In this study, we used a combination of genetics, biochemistry, and AlphaFold2 complex modeling to uncover the molecular details of how NlpE triggers the Cpx response through an interaction with the CpxA histidine kinase. Remarkably, only a short loop of NlpE is required to activate the Cpx response. A single substitution in this loop inactivates NlpE signaling to Cpx and abolishes an in vivo biochemical NlpE:CpxA interaction. An independent AlphaFold multimer prediction supported a role for the loop and predicted an interaction interface at CpxA. Mutations in this CpxA region specifically blind the histidine kinase to NlpE activation but preserve the ability to respond to other cell envelope stressors. Hence, our work additionally reveals a previously unrecognized complexity in signal integration by the CpxA periplasmic sensor domain.
The effect of the cognitive–emotional dialectic on L2 development: Enhancing our understanding of perezhivanie
Authors: Xu Jinfen , Zhang Shanshan 
Published: March 2023

AbstractThe affective turn in the second language (L2) acquisition literature has witnessed a shift from the periphery to a clear focus on emotions. Nevertheless, this shift tends to examine emotion separately from cognition. Vygotsky's perezhivanie provides a theoretical lens to explore the inextricable interconnectedness of emotion and cognition in a dialectical and nonreductionist way. This article investigates the concept of perezhivanie in two Chinese learners of L2 Japanese and its relevance for their language development. Data mainly collected through interviews and narrative journals were thematically analyzed. The study demonstrates how cognition and emotion dialectically foreground one another (i.e., one gains an upper hand over the other), thus shaping each learner's unique perezhivanie as they undertook to learn Japanese. The study showed that the two students had their own purposes for learning Japanese and that affect functioned as both facilitator and inhibitor of the learning processes. Interestingly, this study does not support the notion that negative affect results in a lack of development and that positive affect always leads to development. It also emphasizes that negative and positive affect constitute a dialectical process.
Promoting young EFL learners’ listening potential: A model of mediation in the framework of dynamic assessment
Authors: Zhang Yanhong 
Published: March 2023

AbstractDynamic assessment (DA) integrates assessment and instruction into an organic unity aimed at promoting learner development through mediation sensitive to the individual's (or in some cases, a group's) current abilities. This article reports on the construction of a model of mediation framed within DA for English‐as‐a‐foreign‐language listening comprehension. The model was implemented in a 1‐semester comparative experimental study in 2 parallel classes of Grade 8 in an urban middle school in central China. For mediation, the experimental class (EC) received four DA sessions aligned to their emerging abilities at all listening stages. Statistical results showed that students in EC outperformed those in the control class significantly in both a posttest and a near transfer assessment test, a more complex task intended to assess development in a more accurate manner, although they showed no significant advantage in the far TA test. Microgenetic analysis of the development of a sample of 9 students revealed that the mode of mediation used during enrichment permitted the teacher to ascertain students’ listening problems, including their struggles with phonology, lexicon, grammar, and strategy use. The value of the DA mediation model is discussed as a dialectical unity of both a diagnostic tool and a pedagogical framework in the context of young L2 learners.
Cornelius Cardew's Camouflage and Bun No. 2
Authors: METCALF THOMAS 
Published: March 2023

ABSTRACTCornelius Cardew's Bun No. 2 (1964) provides a unique opportunity to reconcile the composer's indeterminate graphic score Treatise (1963–7) with a more determinately scored orchestral work which uses orthodox staff notation. It represents an amalgamation of Cardew's approach to two notational systems that, owing to their concurrence of use in his oeuvre, can inform our understanding of how graphic scores can be used in determinate compositional processes and vice versa. This article explores why Cardew decided to embark upon this experiment, using contextual information relating to Autumn ’60 (1960) and the influence of other composers, such as Morton Feldman (1926–1987). This is situated in Cardew's notion of ‘camouflage’, a socio‐musical construct relating to the situation and presentation of his widely varied compositional output in the changing musical environment of the late 1950s and early 1960s. The analysis itself covers a small portion of Bun No. 2, drawing extensively upon Cardew's Treatise Handbook (1971), identifying and extrapolating tendencies of musical‐graphical translation and focussing on the use of major and minor triads and their deformation using geometric concepts of ‘perfection’ and ‘imperfection’. Finally, the article considers the implications of this work both for Cardew and for the aesthetics and wider study of graphic score readings, briefly offering a reflection upon the concept of isomorphism in Ludwig Wittgenstein's picture theory (building upon Cline 2020) in relation to the rhetorical notion of ekphrasis (Bruhn 2000) as a means of explaining the uneasy position that this piece occupied for Cardew, read through the lens of camouflage.
#WeWillWin: Mobilisation of Jerusalem's Armenian youth and digital acts of citizenship during the Second Artsakh War
Authors: Levenson Lance 
Published: March 2023

AbstractThis focused digital ethnography explores Armenian diaspora youth mobilisation via hashtag activism concerning a homeland conflict, examining the impact of digital citizenship acts on diaspora nationalism and identity negotiation. Taking Jerusalem's Armenian School as a case study, I analyse the school's use of Facebook amid a global pandemic to coordinate youth mobilisation around the viral hashtag #WeWillWin during the Second Artsakh War between Armenians and Azerbaijanis. Ethnographic content analysis was applied to student‐created audiovisual materials, which were contextualised using interviews with schoolteachers and young adults. Considering complex geopolitics within a conflict‐ridden landscape, Armenian youth's audiovisual posts in cyberspace represent empowering, performative statements of identity and citizenship tethered to an imagined Armenian transnation. For diasporic youth facing uncertainty, crisis and marginalisation in local milieus, social media can constitute hybrid spaces between home and homeland for expressions of agency and dissent, identity negotiation and citizenship performance.
The plant response to highCO2levels is heritable and orchestrated byDNAmethylation
Authors: Panda Kaushik , Mohanasundaram Boominathan , Gutierrez Jorge , McLain Lauren , Castillo S. Elizabeth , Sheng Hudanyun , Casto Anna , Gratacós Gustavo , Chakrabarti Ayan , Fahlgren Noah , Pandey Sona , Gehan Malia A. , Slotkin R. Keith 
Published: March 2023

SummaryPlant responses to abiotic environmental challenges are known to have lasting effects on the plant beyond the initial stress exposure. Some of these lasting effects are transgenerational, affecting the next generation. The plant response to elevated carbon dioxide (CO2) levels has been well studied. However, these investigations are typically limited to plants grown for a single generation in a high CO2environment while transgenerational studies are rare.We aimed to determine transgenerational growth responses in plants after exposure to high CO2by investigating the direct progeny when returned to baseline CO2levels.We found that both the flowering plantArabidopsis thalianaand seedless nonvascular plantPhyscomitrium patenscontinue to display accelerated growth rates in the progeny of plants exposed to high CO2. We used the model species Arabidopsis to dissect the molecular mechanism and found that DNA methylation pathways are necessary for heritability of this growth response.More specifically, the pathway of RNA‐directed DNA methylation is required to initiate methylation and the proteins CMT2 and CMT3 are needed for the transgenerational propagation of this DNA methylation to the progeny plants. Together, these two DNA methylation pathways establish and then maintain a cellular memory to high CO2exposure.