bluuebunny/crossref_metadata_2025_split huggingface dataset:
El humor y la ironía en Un mundo para Julius de Alfredo Bryce Echenique
Authors: Rivas Sucari Henry César 
Published: March 2023

La obra del escritor peruano Alfredo Bryce Echenique ha sido objeto de múltiples investigaciones desde los estudios literarios y las ciencias sociales, tanto en Perú como en el extranjero. La narrativa peculiar que posee se caracteriza, fundamentalmente, por el tratamiento de temas con representación social peruana, principalmente, ambientados en la segunda parte del siglo XX. Otra línea temática que ejecuta es la que corresponde a las vivencias de los latinoamericanos en Europa. La trama argumental de sus obras trasciende hacia una crítica social desde la perspectiva de los individuos que no encajan en sus sociedades representadas. Para el tratamiento de esta narrativa, utiliza algunas estrategias novedosas, como la oralidad, la intertextualidad, la cultura popular, y el humor y la ironía. En este sentido, el presente artículo analiza la forma en que Bryce Echenique utiliza el humor y la ironía como estrategias efectivas para la articulación de su primera novela, Un mundo para Julius. Para ello, se indaga su propia concepción sobre el humor en la literatura[1].

[1]Esta investigación forma parte de la elaboración de la tesis Teoría de la novela en la narrativa de Alfredo Bryce Echenique en el Doctorado en Literatura Peruana y Latinoamericana de la UNMSM.
Genetic and epigenetic characteristics of non-muscle invasive and muscle invasive bladder cancer in patients infected by human papillomavirus: literature review
Authors: Pulatova A. A. , Dimitriadi S. N. , Kutilin D. S. , Zykova T. A. , Shevchenko A. N. , Goncharov S. I. , Khvan V. K. 
Published: March 2023

Infectious diseases and chronic inflammation are important risk factors for the development of malignant tumors in humans. One of the key infectious agents involved in human oncogenesis is the human papillomavirus (HPV). Non-muscle invasive bladder cancer is defined as a superficial neoplasia limited to the mucosa, aggravated by recurrence in 80 % of cases and progression in 30 % of cases. The development of this disease is associated with the influence of various carcinogenic agents, including HPV. Currently, a direct relationship has been revealed between the presence of viral DNA in the tumor tissue of the bladder and markers of proliferative activity, angiogenesis, and apoptosis factors. More and more researchers believe in the involvement of the virus in the development of recurrent forms of bladder cancer and the emergence of its invasive/poorly differentiated forms. Improving the diagnosis and postoperative monitoring of non-muscle invasive and muscle invasive bladder cancer is not possible without the improvement of minimally invasive molecular methods, which requires an understanding of the molecular mechanisms of HPV-associated carcinogenesis.Therefore, this review focuses on the analysis of the molecular mechanisms of HPV effect on progression of non-muscle invasive and muscle invasive bladder cancer. The features of miRNA expression in patients with papillomavirus infection of high oncogenic risk types and non-muscle invasive or muscle invasive bladder cancer are considered in detail. In particular, the role of miR-34а, -218, -20a, -424, -200a, -205-5p, -944, -100, -99a, -202, -30a, -145-5p, -195 and -199a-5 is described in the development and progression of bladder cancer. The mechanisms of disruption in the functioning of key cell signaling pathways during HPV integration in patients with bladder cancer, including changes in gene copy number and methylation level, are also considered.However, the number of HPV-positive tumor specimens that have been comprehensively analyzed using genome-wide studies in the literature remains small. Larger patient cohorts would be useful to further refine HPV-associated integration events and genomic changes, as well as to study clinical manifestations of the consequences of these alterations. Further research on the clinical implications of the observed genomic changes is needed to accurately stratify patients for targeted therapy, radiation and chemotherapy.
Study of the action of peripheral blood T-lymphocytes on renal cell carcinoma cells in model systems
Authors: Kuzevanova A. Yu. , Khalmurzaev O. A. , Borunova A. A. , Apanovich N. V. , Zabotina T. N. , Alimov A. A. , Matveev V. B. , Karpukhin A. V. 
Published: March 2023

Background. The introduction of immunotherapy based on immune checkpoint inhibitors has significantly improve the effectiveness of kidney cancer treatment. Nevertheless, not all patients respond to such treatment and there are no reliable predictive markers. Therefore, the development of a model system for assessing the cellular immune response to a tumor seems to be an urgent task.Aim. Development of a model to assess the T-cell immune response was the focus of this study.Materials and methods. Primary tumor cell culture and peripheral blood T-cell fraction were obtained under standard sterile conditions. T-cell activation were perform via anti-CD3 and anti-CD28 antibodies. The cell index was assessed using the RTCA xCELLigence biosensor technology (ACEA Biosciences, USA).Results. Tumor and T-cells from the same patient were cultured together to assess the growth rate of the tumor cell population. Measurements were taken at 30-minute intervals. The duration of observation was 24 hours. It has been shown that non-activated T-cells do not affect the proliferative properties of cultured cancer cells. On the contrary, activated T-cells suppressed the proliferative properties of cancer cells, which was associated with an increase in the proportion of Т-cells carrying the HLA-DR receptor (CD3+HLA–DR+) because of activation. Tumor-specific T-cell activity can lead to three consequences: lack of effect, partial suppression of proliferative properties, and complete death of tumor cells. In the latter case, the absence of such cells was determined by flow cytometry.Conclusion. The developed approach makes it possible to evaluate the cytotoxic properties of T cells in relation to tumor cells in a particular patient. The advantage of this method is that the measurement can be carried out in the presence of immune checkpoint inhibitors. The proposed method may be useful for evaluating the treatment regimen within the framework of personalized therapy.
Results of surgical treatment of malignant kidney tumors based on the materials of urology departments of the Siberian State Medical University clinics
Authors: Latypov V. R. , Popov V. S. , Latypova V. N. , Novikov S. I. , Akhmedov D. B. , Zebzeeva O. S. 
Published: March 2023

Aim. To analyze the results of treatment of patients with kidney tumors in urology departments of the Siberian State Medical University clinics.Materials and methods. The number of patients with kidney tumors hospitalized in the urology department of the general surgery clinic was 7–10 % of the total annual number of surgical interventions in the urology department. We analyzed 132 cases of malignant kidney tumors. All patients went through imaging and laboratory studies.Results. Treatment results are known in 125 (94.0 %) patients. Mean age of patients was 57.9 years (27 to 86), there were 77 men and 55 women (1.4:1 ratio). Mean tumor size was 6.5 ± 3.6 cm, no significant differences were observed between men and women. Radical nephrectomy was performed in 75 (56.8 %) patients, kidney resection in 57 (43.2 %) patients. Tumor size in nephrectomy cases was 8.2 ± 3.7 cm and 4.3 ± 2.1 cm in kidney resection (p <0.05). In patients with larger tumors five-year survival was lower: tumor size £4 cm was associated with five-year survival of 79.6 %, while tumor size >7 cm with only 36.9 % (p = 0.001).In our study, 23 (17.4 %) patients with inferior vena cava thrombosis were operated on: 11 (8.3 %) men, 12 (9.1 %) women. Mean age of patients with inferior vena cava thrombosis was 57.2 years (between 35 and 74 years). In this group of patients, mean tumor size was 10.8 ± 4.1 cm (between 4.2 and 19). Based on TNM classification, tumors were classified as follows: T3b stage – 17 (12.9 %), T4 stage – 6 (4.5 %), N0 – 15 (11.4 %), N+ – 8 (6.1 %). Left kidney was affected in 6 (4.5 %) cases, right kidney was affected in 17 (12.9 %) cases. Type of surgery performed in this group of patients was classified as: radical nephrectomy with thrombectomy and lymphadenectomy, one case included resection of the inferior vena cava with a section reconstructed using a xenopericardial transplant. Mean surgery duration was 212.4 ± 52.3 (130–320) minutes. Mean blood loss volume was 1177.0 ± 933.4 (100–4600) ml. Postoperative complications were observed in 35 (21.2 %) patients. Overall five-year survival for patients with malignant kidney tumors was 61.8 %, for patients with tumor thrombosis it was 31.3 %.Conclusion. Surgical treatment of patients with malignant kidney tumors allows to significantly improve patients’ survival preserving quality of life.
The probable role of retroelements in the development of Wilms’ tumor in chromosomal syndromes
Authors: Mustafin R. N. 
Published: March 2023

The review article analyzes the data accumulated in the literature on the association of Wilms’ tumor with chromosomal syndromes and searches for possible causes of this phenomenon. In 10 % of all cases, nephroblastoma is represented by a hereditary tumor syndrome due to germline mutations in suppressor genes, mainly in the WT1 gene, less often in WT2, WTX, CTNNB1, TP53. These genes are associated with retroelements that play a role in the development of Wilms’ tumor, promoting carcinogenesis, causing genome instability. LINE-1 retroelement is a negative regulator of WT1 expression, while suppressor genes are characterized by suppression of retroelement activity. Part of the pathogenesis of Perlman, Beckwith-Wiedemann, WAGR, and trisomy 18 syndromes caused by germline microdeletions is the activation of retroelements that promote somatic chromosomal rearrangements, including deletions, insertions, and translocations, which are characteristic of sporadic Wilms’ tumor. Long noncoding RNAs and microRNAs are formed from retroelements during evolution or directly during the processing of their transcripts. At the same time, long noncoding RNAs affect the development of Wilms’ tumor by various mechanisms: due to the effect on ferroptosis (lncRNA AC007406.1, AC005208.1, LINC01770, DLGAP1-AS2, AP002761.4, STPG3-AS1, AC129507.1, AC234772.2, LINC02447, AC009570.1, ZBTB20-AS1 and LINC01179), Wnt/β-catenin signaling pathways (HOTAIR, MEG3), apoptosis (HAGLROS), regulation of expression of specific miRNAs (SNHG6, MEG8, XIST, SNHG16, DLEU1, CRNDE, SNHG6, DLGAP1, OSTM1-AS1, EMX2OS, H19). Analysis of the MDTE DB database revealed nephroblastoma-associated miRNAs that originate from retrotransposons. These include miR-192, -335, -378c, -562, -630, -1248. These molecules are promising for possible use in the pathogenetic treatment of Wilms’ tumor due to their effect on pathologically activated retrotransposons.
Video endoscopic inguinofemoral lymphadenectomy in penile cancer
Authors: Metelkova E. A. , Nesterov P. V. , Gurin E. V. , Ukharskiy A. V. 
Published: March 2023

Background. Dissection of inguinal lymph nodes is an important method of treatment of invasive and locally advanced penile cancer. Unfortunately, the procedure is associated with very high complication rate exceeding 50 %.Aim. To perform retrospective comparative analysis of oncological outcomes, intraoperative and early postoperative complications of open and endoscopic inguinofemoral lymphadenectomy in treatment of patients with penile cancer.Materials and methods. Treatment outcomes of 64 patients with penile cancer who underwent open or video endoscopic lymphadenectomy were analyzed. Primary and secondary surgical treatment outcomes were evaluated.Results. Open inguinofemoral lymphadenectomy was performed in 54 patients, video endoscopic in 10. Analysis of primary surgical results showed a significant (3-fold) reduction of the duration of lymphorrhea and the duration of hospitalization (2-fold) in patients of the video endoscopic lymphadenectomy group. There was no difference in the number of removed lymph nodes in the two types of surgeries. Average operative time for video endoscopic lymphadenectomy was 15–20 % longer than operative time of open intervention. Analysis of safety indicators showed that during open surgery, the frequency of wound infection was 24 %, skin flap necrosis – 55.5 %, wound dehiscence – 52 %, lymphedema – 15 %. No such complications were observed in lateral video endoscopic inguinofemoral lymphadenectomy.Conclusion. Video endoscopic inguinofemoral lymphadenectomy has significant advantages compared to open method in terms of reduction of the rate of surgical complications and duration of hospitalization.
Lawmaking in the Republic of Crimea: The Current State and Prospects
Authors: Bondarchuk I. V. 
Published: March 2023

The paper examines the issue of the lawmaking development in the Republic of Crimea as a subsystem of lawmaking in the Russian Federation in modern conditions. The author analyzes historical stages of development of the Crimea legislation from the 1991 Referendum to the adoption of the new Constitution of the Republic of Crimea in 2014 and the factors contributing to the effectiveness of lawmaking technologies.Using the methods of synthesis and comparison, as well as the formal legal method, the author identifies two models of development of lawmaking in the constituent entities of the Russian Federation. The author draws attention to the rule-making policy in the regions and determines the role of the RF Constitutional Court decisions in improving regional legislation.From the standpoint of the theory of organization, the author considers lawmaking as a higher stage of development of lawmaking activity and a peculiar form of legal activity. Considerable attention is paid to the study of the concepts of interaction between lawmaking systems of the Republic of Crimea and the Russian Federation.Lawmaking in the constituent entities of the Russian Federation is an integral part of the unified law-forming process of the federal State. The Republic of Crimea, like other constituent entities of Russia, is endowed with lawmaking competence. At the same time, regional lawmaking should be a logical continuation of the federal one with due regard to regional peculiarities. And in no case it can confuse, complicate, contradict, duplicate federal rule-making.
A Time-Domain Approach for Accurate Spectral Source Estimation with Application to Ridgecrest, California, Earthquakes
Authors: Al-Ismail Fatimah , Ellsworth William L. , Beroza Gregory C. 
Published: March 2023

ABSTRACTWe determine the seismic moment and corner frequency of earthquakes using narrowband, time-domain measurements of the maximum shear-wave displacement amplitude. Each S wave is passed through a set of one-octave band-pass filters between 0.25 and 32 Hz to measure the peak amplitude on the horizontal components. Following the development of Richter (1935) local magnitude scale, we derive a functional form of maximum amplitude versus distance, but separately for each frequency band, and use them to estimate wave attenuation as a function of frequency and distance. Attenuation is a strong function of frequency, approximately proportional to 1/f, with path averaged Q increasing (attenuation decreasing) with propagation distance. We use these empirical attenuation curves to correct the time-domain peak amplitudes to a reference distance of 10 km to recover the source spectrum. We find that the spectral shape is consistent with the Brune model, showing a well-defined plateau at low frequency and a decay at high frequency proportional to ω−2. We use the median spectrum for stations at distances up to 120 km for each event to measure the moment and corner frequency. This time-domain method provides a reliable and efficient way to accurately measure earthquake source parameters.
Composições de Substratos e Seus Efeitos no Crescimento e Fisiologia de Mudas de Teca
Authors: Vieira Cristiane Ramos , Marinho Vieira Araújo Maicon , Dos Santos Soares Joás , Paz da Costa Patrícia , Araújo Botelho Rosangela , Natalina Zattar da Silva Rosangela 
Published: March 2023

Para estabelecer plantios florestais, há que se atentar para a produção de mudas, que também deve ser de qualidade. Diante disso, o presente trabalho teve por objetivo avaliar algumas combinações entre substrato comercial, solo, e diferentes materiais orgânicos, e seus efeitos no crescimento e fisiologia de mudas de teca (Tectona grandis). O experimento foi realizado em delineamento inteiramente casualizado, com os tratamentos: T1 – 100% solo (solo nativo); T2 - 100% substrato comercial (SC); T3 – 50% solo + 25% resíduo bovino (RB) + 25% resíduo de aves (RA); T4 – 50% solo + 25% RB + 25% resíduo suíno (RS); T5 – 25% SC + 25% solo + 10% RA + 20% RB + 20% RS; T6 – 25% SC + 25% solo + 10% RS + 20% RA + 20% RB; T7 – 25% SC + 25 % solo + 25% RS + 25% RB; T8 – 25% SC + 25 % solo + 25% RS + 25% RA. Ao final de 90 dias, foram obtidas informações a respeito das características morfológicas e características fisiológicas das mudas, verificando-se que, a condição do tratamento 8 foi a mais favorável porque permitiu a obtenção de mudas de melhor qualidade. Esse resultado foi influenciado pela taxa líquida fotossintética, condutância estomática e concentração intrínseca de CO2 das plantas, em condições adequadas.
Palavras-chave: Tectona grandis. Resíduos Orgânicos. Produção de Mudas. Adubação.

Abstract
In order to establish forest plantations, it is necessary to pay attention to the production of seedlings, which must also be of quality. Therefore, this study aimed to evaluate combinations between commercial substrate, soil, and different organic materials, and their effects on the growth and physiology of teak (Tectona grandis) seedlings. The experiment was carried out in a completely randomized design, with the treatments: T1 – 100% soil (S - native soil); T2 - 100% commercial substrate (SC); T3 – 50% soil + 25% bovine residue (RB) + 25% poultry residue (RA); T4 – 50% solo + 25% RB + 25% swine residue (RS); T5 – 25% SC + 25% solo + 10% RA + 20% RB + 20% RS; T6 – 25% SC + 25% solo + 10% RS + 20% RA + 20% RB; T7 – 25% SC + 25 % solo + 25% RS + 25% RB; T8 – 25% SC + 25 % solo + 25% RS + 25% RA. At the end of 90 days, information was obtained about the morphological and physiological characteristics of the seedlings, verifying that the condition of treatment 8 was the most favorable because it allowed the obtainment of quality seedlings. This result was influenced by the liquid photosynthetic rate, stomatal conductance and intrinsic CO2 concentration of the plants, under suitable conditions.
Keywords: Tectona grandis. Organic Residues. Seedlings Production. Fertilization.
RELATO DE EXPERIÊNCIA: UMA TUTORIA, NA DISCIPLINA DE ATUALIZAÇÃO PROFISSIONAL
Authors: Mendes Maria Cristina Barbosa , Lima Neuza Rejane Wille , Gomes Suzete Araújo Oliveira , Mariani Braz Ruth Maria 
Published: March 2023

No mercado de trabalho em constantes mudanças necessitamos de profissionais atualizados e a formação continuada é importante para que possa ter êxito. Assim, este artigo trata-se de relato de experiência, a partir do ponto de vista dos tutores, alunos do curso de doutoramento, em acompanhamento aos professores ministrantes da disciplina de atualização profissional, em um curso de mestrado profissional. Utilizamos a proposta metodológica ao curso denominada Desenho Educacional Complexo, onde podemos preparar, executar e refletir e são engrenagens que trabalham de forma integrada. Este relato contextualiza a disciplina no programa da pós-graduação, indica como foi organizada a prática da tutoria ao longo de um semestre e avalia os resultados do trabalho desempenhado, a partir das respostas dos concluintes da disciplina. Tivemos como resultado que o trabalho desenvolvido na tutoria trouxe a valorização da autonomia da pessoa com deficiência, a partir da adoção do modelo social de conviver todos com todos, aplicado na prática pedagógica, com isso, percebemos que os discentes passaram ter uma mudança na direção da apreciação de confeccionar materiais de forma acessível. Concluímos que o processo da tutoria gera um aperfeiçoamento positivo quanto à experiência docente no Ensino Superior e foi possível rever conceitos para a pesquisa acadêmica, conhecer pessoas novas e transmitir informações sobre novas tecnologias
Brief: An MWD Downhole Assistant Driller
Authors: Hutchinson Mark , Henneuse Henry , Dubinsky Vladimir 
Published: March 2023

Introduction
Measurement-while-drilling (MWD) systems have been used historically to position a wellbore correctly and to evaluate geological formations around the borehole. In addition to having real-time information about where you are drilling and what you are drilling, it is also advantageous to have information about how the drilling process is proceeding. The interpretation of downhole drilling characteristics from surface measurements requires specialized expertise and is not always reliable. Placing a downhole MWD device that measures both drilling forces and motions near the bit provides more reliable diagnoses of drilling phenomena. Presenting this information on an easily interpreted rig-floor display permits the driller to "feel" how a well is drilling.
Brief: A Study of the Effect of Drilling-Fluid Fines on Reservoir Performance
Authors: Fraser L. J. , Reid P. I. , Williamson L. D. , Enriquez F. P. 
Published: March 2023

Introduction
Most oilfield drilling is undertaken for the purpose of producing hydrocarbons. During the era of high oil and gas prices, little attention was paid to the effect that the process of penetrating the reservoir had on its ability to release hydrocarbons. In the current climate of reduced pricing, the subject of reservoir impairment has become the focus of widespread industry attention. One of the most damaging effects that a drilling fluid can have on reservoir producibility is caused by the presence of fine solids in the fluid. This work, carried out at Schlumberger Cambridge Research, focused on understanding the mechanisms by which fines invade sandstone matrices and the circumstances under which such invasion occurs. We further pursued an understanding of the mechanisms underlying the unexpectedly low damaging performance being observed with fluids based on a complex formed between conventional oilfield grade bentonite and highly cationic mixed metal hydroxide (MMH) crystals. All investigations have been directed at an openhole, nonperforated completion scenario.