bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sublethal and transgenerational effects of pyridaben exposure on the fitness and gene expression of Panonychus citri
Authors: Pan Deng , Xia Menghao , Luo Qiujuan , Li Chuanzhen , Yuan Guorui , Wang Jinjun , Dou Wei 
Published: April 2023

AbstractBACKGROUNDPanonychus citri is a globally dominant citrus plant pest mite. Pesticide‐induced population resurgence is a concern for mite control. Exposure to sublethal concentrations of pesticides has stimulated reproduction and outbreak risks in many pests. Pyridaben, a mitochondrial electron transport inhibitor, has been frequently used worldwide in mite control. In the study, sublethal and transgenerational effects of pyridaben exposure on Pyr_Rs (resistant) and Pyr_Control (susceptible) strains were systematically investigated in both exposed parental generation (F0) and unexposed offspring generations (F1 and F2) by evaluating life‐table and physiological parameters.RESULTSAfter exposure to pyridaben, the fecundity of both strains was significantly reduced in F0 generation while significantly induced in F1 generation. Interestingly, these effects also stimulated the fecundity of the F2 generation in Pyr_Control strain while no significant effects occurred for Pyr_Rs strain. The intrinsic rate of increase (r) and finite rate of increase (λ) were significantly decreased only in F1 generation of Pyr_Control strain after exposure treatment. Meanwhile, the population projection indicated a smaller population size in F1 generation of Pyr_Control strain while a population increase for Pyr_Rs strain after sublethal treatment. Subsequent detoxification enzyme assays indicated that only P450 activities in F0 generation were significantly activated by LC30 exposure to pyridaben in both strains. Significant downregulation of reproduction‐related (Pc_Vg) genes was observed in the F0 generations of both strains. Significant upregulation of P450 (CYP4CL2) and Pc_Vg of the F1 generation in both strains suggested the presence of delayed hormesis effects on the reproduction and developed tolerance to pyridaben, although the effects did not last over a longer period (F2 generation).CONCLUSIONThese results provide evidence for transgenerational hormesis effects of low concentrations of pyridaben exposure that may lead to population increase and resurgence risks of resistant‐mites in natural settings by stimulating reproduction. © 2023 Society of Chemical Industry.
Antiproliferative effect of selexipag active metabolite MRE‐269 on pulmonary arterial smooth muscle cells from patients with chronic thromboembolic pulmonary hypertension
Authors: Kuramoto Kazuya , Ogawa Aiko , Kiyama Kazuko , Matsubara Hiromi , Ohno Yuji , Fuchikami Chiaki , Hayashi Kyota , Kosugi Keiji , Kuwano Keiichi 
Published: April 2023

AbstractChronic thromboembolic pulmonary hypertension (CTEPH) is a group 4 pulmonary hypertension (PH) characterized by nonresolving thromboembolism in the central pulmonary artery and vascular occlusion in the proximal and distal pulmonary artery. Medical therapy is chosen for patients who are ineligible for pulmonary endarterectomy or balloon pulmonary angioplasty or who have symptomatic residual PH after surgery or intervention. Selexipag, an oral prostacyclin receptor agonist and potent vasodilator, was approved for CTEPH in Japan in 2021. To evaluate the pharmacological effect of selexipag on vascular occlusion in CTEPH, we examined how its active metabolite MRE‐269 affects platelet‐derived growth factor‐stimulated pulmonary arterial smooth muscle cells (PASMCs) from CTEPH patients. MRE‐269 showed a more potent antiproliferative effect on PASMCs from CTEPH patients than on those from normal subjects. DNA‐binding protein inhibitor (ID) genes ID1 and ID3 were found by RNA sequencing and real‐time quantitative polymerase chain reaction to be expressed at lower levels in PASMCs from CTEPH patients than in those from normal subjects and were upregulated by MRE‐269 treatment. ID1 and ID3 upregulation by MRE‐269 was blocked by co‐incubation with a prostacyclin receptor antagonist, and ID1 knockdown by small interfering RNA transfection attenuated the antiproliferative effect of MRE‐269. ID signaling may be involved in the antiproliferative effect of MRE‐269 on PASMCs. This is the first study to demonstrate the pharmacological effects on PASMCs from CTEPH patients of a drug approved for the treatment of CTEPH. Both the vasodilatory and the antiproliferative effect of MRE‐269 may contribute to the efficacy of selexipag in CTEPH.
Multiomics endotyping of preterm infants with bronchopulmonary dysplasia and pulmonary hypertension—A pilot study
Authors: Siddaiah Roopa , Oji‐Mmuo Christiana , Aluquin Vincent P. R. , Kawasawa Yuka Imamura , Donnelly Ann , Rousselle Dustin , Fuentes Nathalie , Austin Eric D. , Silveyra Patricia 
Published: April 2023

AbstractPulmonary hypertension associated with bronchopulmonary dysplasia is a severe complication of preterm birth resulting in high mortality of up to 50% within the first 2 years of life. There is a direct relationship between bronchopulmonary dysplasia severity and incidence of associated pulmonary hypertension. However, it is challenging to clinically characterize severe bronchopulmonary dysplasia with and without pulmonary hypertension and there is need for better understanding of the two entities. Our main objective is to identify markers to help understand biological processes and characterize infants with pulmonary hypertension associated with bronchopulmonary dysplasia using tracheal aspirates. We conducted an unbiased multiomic analysis of tracheal aspirates via microRNA (miRNA) polymerase chain reaction arrays, RNA sequencing, and mass spectrometry proteomics in preterm infants with severe bronchopulmonary dysplasia with and without pulmonary hypertension (n = 46). Our pilot study analysis revealed 12 miRNAs (hsa‐miR‐29a, has‐miR‐542‐3p, has‐miR‐624, has‐miR‐183, hsa‐miR‐501‐3p, hsa‐miR‐101, hsa‐miR‐3131, hsa‐miR‐3683, hsa‐miR‐3193, hsa‐miR‐3672, hsa‐miR‐3128, and hsa‐miR‐1287), 6 transcripts (IL6, RPL35P5, HSD3B7, RNA5SP215, OR2A1‐AS1, and RNVU1‐19), and 5 proteins (CAPS, AAT, KRT5, SFTPB, and LGALS3BP) with significant differential expression in preterm infants with severe lung disease with pulmonary hypertension when compared with infants with severe lung disease but no pulmonary hypertension. Pathway analysis of the integrated multiomic expression signatures revealed NFkB, VEGF, SERPINA1, IL6, and ERK1/2 as target molecules and cellular development, cellular growth and proliferation, and cellular movement as key affected molecular functions. Our multiomic analysis of tracheal aspirates revealed a comprehensive thumbprint of miRNAs, mRNAs, and proteins that could help endotype infants with severe lung disease and pulmonary hypertension.
Tezepelumab treatment for allergic bronchopulmonary aspergillosis
Authors: Ogata Hiroaki , Sha Kachi , Kotetsu Yasuaki , Enokizu‐Ogawa Aimi , Katahira Katsuyuki , Ishimatsu Akiko , Taguchi Kazuhito , Moriwaki Atsushi , Yoshida Makoto 
Published: April 2023

AbstractAn 82‐year‐old man had been diagnosed with asthma. He experienced repeated exacerbations requiring treatment with a systemic corticosteroid despite being treated with medications including high‐dose fluticasone furoate/umeclidinium/vilanterol, montelukast sodium, and theophylline; treatment with mepolizumab was then initiated. The patient had been free from exacerbations for 15 months; however, he suffered from post‐obstructive pneumonia and atelectasis secondary to mucoid impaction in the right middle lobe of the lung, accompanied by a productive cough, wheezing, dyspnea, and right chest pain. In addition to the development of mucus plugs, the levels of serum IgE specific to Aspergillus spp. became positive; a definite diagnosis of allergic bronchopulmonary aspergillosis (ABPA) was established. The patient underwent treatment with tezepelumab. Over 3 months, the mucus plugs and pulmonary opacities diminished gradually in parallel with the improvement in the control of asthmatic symptoms. Tezepelumab might provide a novel steroid‐sparing strategy for the management of ABPA, although further studies are required.
Decentralized attack detection for multi‐area power systems via interconnection‐decoupled sliding mode observer
Authors: Xu Kun , Niu Yugang 
Published: April 2023

AbstractThis article deals with the false data injection attack (FDIA) detection problem for multi‐area power systems. Considering the large‐scale characteristic of the multi‐area power systems, a novel decentralized detection scheme is proposed to detect FDIAs. First, an unknown input sliding mode observer (UI‐SMO) is designed to decouple the interconnected terms, meanwhile, a robust term in the UI‐SMO can attenuate the effect of the load variation, by which the obtained residual is only sensitive to local FDIAs. The strict reachability of the sliding surface in the estimate error space is ensured by the robust term with an auxiliary variable, and the stability of the sliding mode dynamics is achieved. Then, a detection logic is delicately designed based on a two‐phase residual threshold. Due to the strong attenuating ability to load variation, the proposed detection scheme shows better detectability than some existing works with only decoupling interconnections. Finally, the theoretical results are backed up by a three‐area power system simulation with comparison between proposed UI‐SMO‐based and traditional UIO‐based detection scheme.
Electrodeposition of a Near‐Eutectic Sn‐Ag Alloy from a Mixed Choline Chloride, Ethylene Glycol and Urea Electrolyte
Authors: Shikun Marina A. , Vrublevskaya Olga N. , Sviridov Dmitry V. 
Published: April 2023

AbstractTernary mixture of choline chloride, ethylene glycol and urea (molar ratio 1 : 1 : 1) has been proposed as non‐aqueous media for the electrochemical plating in galvanostatic mode of tin‐silver alloy coatings. The conditions for the deposition of an alloy with a composition and melting temperature close to the eutectic, which is in demand for microassembly in the electronic industry, have been determined. The significant features on the simultaneous tin(II) and silver(I) reduction and the alloy formation are revealed. It has been determined that silver(I) is reduced from the solution both electrochemically and by the galvanic displacement with freshly deposited tin. The presence of silver on the surface of the coatings initiates underpotential tin(II) reduction. The interactions of components in the non‐aqueous electrolyte have been studied for the first time by IR spectroscopy, and the formation of coordination compounds between tin(II) and silver(I) ions and solvent molecules has been revealed.
Deep Eutectic Solvent‐Mediated Oxidative Homocoupling of Terminal Alkynes to 1,3‐Diynes under Mild Green Conditions
Authors: Bhise Rupali S. , Ghorpade Prashant V. , Mehta Viral R. , Shankarling Ganapati S. 
Published: April 2023

AbstractWe prepared a commercially viable Deep Eutectic Solvent (DES) based on Choline Chloride‐Urea‐copper acetate for the first time. It mediates the homocoupling of terminal alkynes, using air as an oxidant. Water is the only by‐product of the entire process. The method avoids ligands, bases, oxidants, and costly palladium catalysts, which qualifies the process greener than ever. The DES can be reused at least three times without affecting the reaction yield significantly. The key features of the protocol that qualify the process as green include the ambient reaction temperatures, lesser use of conventional organic solvents in the reaction, higher yields, and easy product isolation qualify the protocol as a green process.
Acetylcholine Conformational Flexibility and Its Neutral Hydrolysis in Aqueous Solution
Authors: Fadilla Rizka N. , Rusydi Febdian , Madinah Roichatul , Dipojono Hermawan K. , Ahmad Faozan , Mudasir Mudasir , Puspitasari Ira , Morikawa Yoshitada 
Published: April 2023

AbstractEnzymatic hydrolysis is the main target to deal with ACh depletion. However, a recent study indicates that the non‐enzymatic one may contribute to the depletion. This study highlights the necessity of considering possible conformers, discrete‐continuum models, and dispersive effects for investigating the neutral (non‐enzymatic) hydrolysis of flexible molecules in aqueous solution. We systematically built the possible conformers within the first‐principles framework. The results confirm the reactivity of high‐energy ACh conformer towards neutral hydrolysis. We proposed that conformational changes occur before the hydrolysis. The calculated activation and reaction energy shows that the discrete‐continuum solvation model gives the closest result to experimental observations. This study also shows that neglecting dispersive effects brings unreliable structures in the initial state, which leads to unreliable activation energy.
Synthetic Access to Bis(pyrazolyl)methanes using cost‐efficient Triethylammonium Hydrogen Sulfate Ionic Liquid: Evaluation of Antioxidant Activity via in silico and in vitro Studies
Authors: Teli Pankaj , Sahiba Nusrat , Manhas Anu , Jha Prakash C. , Meena Priyadarshi , Agarwal Shikha 
Published: April 2023

AbstractA highly efficient, facile and greener approach has been developed for the synthesis of bis(pyrazolyl)methanes. The method involves a reaction of 3‐methyl‐1‐phenyl‐2‐pyrazoline‐5‐one and substituted aromatic/heterocyclic aldehydes at ambient reaction conditions using ionic‐liquid, triethylammonium hydrogen sulfate to yield desired bis(pyrazolyl)methanes in excellent yields (85–96 %). The significant aspect of this protocol is the use of ionic liquid as a replacement of toxic and expensive metal catalysts thereby reducing the production of harmful chemical wastes and avoiding the use of toxic and volatile reagents in the synthesis. The catalyst was easily separated and reused up‐to five runs without significant decrease in its catalytic activity. Molecular docking studies were conducted on Cytochrome P450 3 A4, methylenetetrahydrofolate reductase, and tumor protein to predict their utility as potential anti‐oxidant, and anti‐cancer compounds. The outcome indicates that these synthesized compounds have the scaffold that binds well in the hydrophobic‐pocket of the respective enzyme and the polar groups present in their scaffold form hydrogen‐bonding too. Furthermore, we infer from the docking calculations that, all were docked in the binding domain of 4D75, eleven were docked in the active site of 6FCX and nine compounds were docked within the binding site of 3S7S. Furthermore, the in‐vitro antioxidant activity of synthesized compounds was explored against DPPH and ABTS, and most of the compounds were found to have high to excellent radical scavenging activity.
Morphological and Optical Transformation of Gas Assisted Direct Laser Written Porous Silicon Films
Authors: Fletcher Jesse , Parish Giacinta , Dell John , Keating Adrian 
Published: April 2023

AbstractDirect laser writing (DLW) of mesoporous porous silicon (PS) films is shown to selectively create spatially separated nitridized and carbonized features on a single film. Nitridized or carbonized features are formed during DLW at 405 nm in an ambient of nitrogen and propane gas, respectively. The range of laser fluence required to create varying feature sizes while avoiding damage to the PS film is identified. At high enough fluence, nitridation using DLW has been shown as an effective method for laterally isolating regions on the PS films. The efficacy in preventing oxidation once passivated is investigated via energy dispersive X‐ray spectroscopy. Changes in composition and optical properties of the DL written films are investigated using spectroscopic analysis. Results show carbonized DLW regions have a much higher absorption than as‐fabricated PS, attributed to pyrolytic carbon or transpolyacetylene deposits in the pores. Nitridized regions exhibit optical loss similar to previously published thermally nitridized PS films. This work presents methods to engineer PS films for a variety of potential device applications, including the application of carbonized PS to selectively engineer thermal conductivity and electrical resistivity and of nitridized PS to micromachining and selective modification of refractive index for optical applications.
Super Proton Conductivity Through Control of Hydrogen‐Bonding Networks in Flexible Metal–Organic Frameworks
Authors: Kwon Nam Ho , Han Seunghee , Kim Jihan , Cho Eun Seon 
Published: April 2023

AbstractMetal–organic frameworks (MOFs) have received much attention as a solid‐state electrolyte in proton exchange membrane fuel cells. The introduction of proton carriers and functional groups into MOFs can improve the proton conductivity attributed to the formation of hydrogen‐bonding networks, while the underlying synergistic mechanism is still unclear. Here, a series of flexible MOFs (MIL‐88B, [Fe3O(OH)(H2O)2(O2C‐C6H4‐CO2)3] with imidazole) is designed to modify the hydrogen‐bonding networks and investigate the resulting proton‐conducting characteristics by controlling the breathing behaviors. The breathing behavior is tuned by varying the amount of adsorbed imidazole into pore (small breathing (SB) and large breathing (LB)) and introducing functional groups onto ligands (‐NH2, ‐SO3H), resulting in four kinds of imidazole‐loaded MOFs−Im@MIL‐88B‐SB, Im@MIL‐88B‐LB, Im@MIL‐88B‐NH2, and Im@MIL‐88B‐SO3H. Im@MIL‐88B‐LB without functional groups exhibits the highest proton conductivity of 8.93 × 10−2 S cm−1 at 60 °C and 95% relative humidity among imidazole‐loaded proton conductors despite the mild condition, indicating that functional groups may not be always required to enhance proton conductivity. The elaborately controlled pore size and host–guest interaction in flexible MOFs through imidazole‐dependent structural transformation are translated into the high proton concentration without the limitation of proton mobility, contributing to the formation of effective hydrogen‐bonding networks in imidazole conducting media.
Advanced In Situ Electrochemical Induced Dual‐Mechanism Heterointerface toward High‐Energy Aqueous Zinc‐Ion Batteries
Authors: Wang Qiufan , Tian Guofu , Huang Can , Zhang Daohong 
Published: April 2023

AbstractIn situ electrochemical activation brings unexpected electrochemical performance improvements to electrode materials, while the mechanism behind is still needed to study deeply. Herein, an in situ electrochemically approach is developed for the activation of heterointerface MnOx/Co3O4 by inducing Mn‐defect, wherein the Mn defects are formed through a charge process that converts the MnOx with poor electrochemical activities toward Zn2+ into high electrochemically active cathode for aqueous zinc‐ion batteries (ZIBs). Guided by the coupling engineering strategy, the heterointerface cathode exhibits an intercalation/conversion dual‐mechanism without structural collapse during storage/release of Zn2+. The heterointerfaces between different phases can generate built‐in electric fields, reducing the energy barrier for ion migration and facilitating electron/ion diffusion. As a consequence, the dual‐mechanism MnOx/Co3O4 shows an outstanding fast charging performance and maintains a capacity of 401.03 mAh g−1 at 0.1 A g−1. More importantly, a ZIB based on MnOx/Co3O4 delivered an energy density of 166.09 Wh kg−1 at an ultrahigh power density of 694.64 W kg−1, which outperforms those of fast charging supercapacitors. This work provides insights for using defect chemistry to introduce novel properties in active materials for highly for high‐performance aqueous ZIBs.
Homogeneous, heterogeneous, and enzyme catalysis in microfluidics droplets
Authors: Mei Fang , Lin Hongyu , Hu Lianrui , Dou Wei‐Tao , Yang Hai‐Bo , Xu Lin 
Published: April 2023

AbstractMicrofluidics has received extensive attention due to its ability to rapidly prepare a large number of microdroplets with controlled sizes and defined morphologies. In addition to having large surface areas and controllable confinement environments, these prepared microdroplets can be used as analytical detection devices to screen and optimize various kinetic parameters. This review summarizes recent advances in the microfluidic control of droplet‐based catalytic reactions and discusses the role of these droplets in both homogeneous and heterogeneous catalyzes and in the catalysis of macromolecular biological enzymes in water‐in‐oil and oil‐in‐oil environments. Additionally, the existing problems and future development directions of droplets in catalysis are highlighted to promote the development of catalytic reactions in droplet media and provide guidance for the high‐throughput screening of catalysts and the directed evolution of biological enzymes.
Experimental and simulation analysis of thermal behavior of large‐span roof system under solar radiation
Authors: Wang Mingming , Xin Zhiyong , Liu Xuan , Ou Tong , Wang Dayang , Zhang Yongshan 
Published: April 2023

SummaryThe large‐span metal roof systems can produce a significant nonuniform temperature effect under solar radiation, leading to potential safety hazards. An experiment is conducted to study the nonuniform thermal behavior of a small‐scale continuous welded stainless steel roof (CWSSR) system under solar radiation. The small‐scale CWSSR system considered different roof slopes and sunward side and nightside. The efficiency of the numerical analysis of the thermal behavior of the roof slab is verified in comparison with the experimental results. Based on the numerical and experimental results, the thermal effect of a full‐scale CWSSR system is studied under different orientations, wind speeds, and atmospheric temperature. Through the analysis of research results, the nonuniform thermal features of the CWSSR system are significant and cannot be overlooked. The temperature difference between the sunward side and nightside roof slab is positively correlated with the roof slope. The thermal behavior of the CWSSR system is greatly influenced by wind speeds but is less affected by orientations and atmospheric temperature.
Impact of physico‐chemical properties of nanocellulose on rheology of aqueous suspensions and its utility in multiple fields: A review
Authors: Rana Ashvinder K. , Thakur Vijay Kumar 
Published: April 2023

AbstractNanocellulose (NC), due to its sustainable nature, high aspect ratio, superior mechanical strength, and availability of functionalizable OH groups, has been widely utilized as reinforcement in numerous fluids/plastics. The physico‐chemical properties of NC, like surface characteristics, dimensions/aspect ratio and their concentration, significantly impact the interparticle interactions, such as the extent of hydrogen bonding, van derWaalforces, hydrophobicity, electrostatic attraction/repulsion, and cellulose entanglement, and have been found to play a critical role in regulating the overall rheological characteristics of fluids. The functionalized NC aqueous suspension exhibited unique shear thinning properties, thixotropic behavior, and quick steady‐state viscosity recovery and viscoelastic properties. However, upon adding functionalized NC to other fluids, a different impact was noticed. For instance, it improved the viscosity, G′ and mechanical stability of bio‐ink; the setting time and mechanical strength of cementitious fluids; increased the filtration performance and provided a unique thermo‐thickening impact in case of water‐based drilling‐fluid; enhanced viscosity with time and heat in case of oil recovery, and so forth. Keeping in view the notable dependence of the rheology of fluids on NC additives, in the present review article, the impact of various physico‐chemical properties of NC additives on the rheological behavior of NC aqueous suspension and its utility as a rheology modifier in multiple advanced fields has been explored. This review article, compared to previous studies, warrants an update on the impact of recent NC surface functionalization/blending techniques employed and NC aspect ratio on specific properties of multiple advanced fluids.