bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the Relationship of Lipid Profile, BMI and Blood Pressure among Non-diabetic Hypertensive Patients - A Hospital Based Study
Authors: Baskota Dristi , Shrestha Bishow Raj , Tiwari Saurabh , Poudyel Pragati , Pandey Rachana , Joshi Richa Bhattarai 
Published: January 2023

Introduction: Several research have demonstrated the connection between lipid levels, diabetes mellitus (DM), and hypertension, but none have focused specifically on the association between lipid levels and essential hypertension in Nepal's non-diabetic population.
Aims: To study the relationship between lipid profile, body mass index (BMI), and blood pressure (BP) in the nondiabetic hypertensive population.
Methods: A hospital-based cross-sectional study was conducted among 150 participants. Anthropometric measurements including height, weight and BP were taken. Blood was collected in serum vial for lipid profile [total cholesterol (TC), triglyceride (TG) and low and high density lipoprotein cholesterol (LDLC and HDLC)] after an overnight fasting.
Results: 44.7% were female, and 55.3% were male with the age ranging between 28-80 years. Among 48.67% of the overweight participants, 56.8% were male. 25.33% were obese, among which 52.6% were male. 56% of participants had systolic blood pressure (SBP) ≥140 mmHg and 58% had diastolic blood pressure (DBP) ≥90 mmHg and showed no significance among the gender. Borderline TG level was observed in 76.2% of participants with SBP ≥140 mmHg and in 74.7% with DBP ≥90 mmHg. HDLC vs gender showed significance. SBP and DBP had a significant relationship with LDLC and TC. The association of BMI with BP and lipid profile was not significant.
Conclusion: Dyslipidemia is prevalent among non-diabetic hypertensive individuals. The majority of participants were overweight, however blood pressure and lipid profile did not correlate with BMI presumably because other anthropometric characteristics have better predictive values than BMI.
Fetomaternal Outcome of Instrumental Vaginal Delivery at Nepalgunj Medical College Teaching Hospital Kohalpur
Authors: BC Durga , Jha Rajshree , Das Ram Kumar 
Published: January 2023

Introduction: Instrumental vaginal delivery is performed in second stage of labor to expedite delivery with aim to decrease cesarean section rate. Worldwide 10-20% of laboring women need obstetrics intervention for delivery.
Aims: To evaluate the indication and fetomaternal outcome of instrumental vaginal delivery.
Methods: This is a hospital based cross-sectional study conducted at the department of obstetrics and gynecology. The study was done from July 2021 to July 2022 for a period of one year. Data were collected, recorded in standard proforma and analyzed by using SPPS version 20.
Results: The out of 6123 deliveries, 149(2.4%) had instrumental vaginal delivery. Out of 149 participants, 41.6% were between 20-24 years, 10.7% were of age group 15-19 years and 4% ladies were of >35 years. Instrument delivery was more frequently applied in primigravida in comparison to multigravida (57.3% vs 42.3%) p=0.046. The most common indication for instrumentation was poor maternal effort (41%) followed by fetal distress (33.6%). About 14.1% had postpartum haemorrhage, 3.4% had vulval hematoma, and 38.3% babies had Neonatal Intensive Care unit admission.
Conclusion: Poor maternal effort and fetal distress were the common indications for instrumental delivery with some fetomaternal complications. Inspite of the complications, if used by an expertise, instrumental delivery can reduce the need of cesarean section.
Theoretical Foundations for Entrepreneurship Development Program
Authors: Silwal Yam Bahadur , Poudel Saroj Kumar , Dahal Keshav Prasad , Thapaliya Shekhar , Sah Barun Kumar 
Published: January 2023

Entrepreneurship development is a process of converting an ordinary individual into an entrepreneur. The objective of this study is to examine theories of entrepreneurship development in order to gain a deeper understanding of the development of entrepreneurship. There are a number of entrepreneurship development theories existed in the scholarly field. The study identifies that entrepreneurship development theories are contextual and may not be applicable in all contexts. Some of the theories focus on psychological and knowledge aspects whereas some of them focus on skills, social network, institutional arrangement and support. A single theory has been found to be insufficient for the overall development of entrepreneurship. This study has included that mainly four theories: human capital theory of entrepreneurship development, institutional theory of entrepreneurship development, innovation theory of entrepreneurship development and social capital theory of entrepreneurship development This consolidated form of four theories provides the knowledge, skills, abilities, and practices necessary for an individual to be prepared for entrepreneurship. Findings of this study will provide insights for those government, non-government and private institutions that are involved in the entrepreneurship development programs.
Формування професійної мовленнєвої компетентності майбутнього вчителя початкової школи
Authors: Мірошниченко Оксана 
Published: January 2023

У статті розглядаються питання формування професійної мовленнєвої компетентності майбутнього вчителя початкової школи, як важливої складової професійної підготовки фахівців у системі освіти України. Проаналізовано зміст основних понять «компетенція», «компетентність», «професійна компетентність», «комунікативна компетентність». Висвітлено різні підходи до визначення сутнісної характеристики професійна компетентності, її компонентний склад. Визначено, що процес формування професійної мовленнєвої компетентності майбутніх вчителів англійської мови необхідно здійснювати на основі інтеграції загально-професійних і спеціальних дисциплін, з використанням інтерактивних технологій. Відповідно до вимог концепції НУШ та стандартних програм описано два цикли початкової освіти, відзначивши, що початкова освіта зазнала реформації найперша. Презентовано основні складові компетентності майбутнього викладача, які повинні формуватися у студентів закладів вищої освіти. Встановлено, що процес розвитку професійної компетентності, залежить від навколишнього середовища, тому саме середовище має стимулювати професійний саморозвиток. Виділено етапи формування професійної компетентності. Описано важливість професійно-педагогічного спілкування, яке є основною формою педагогічного процесу і займає вагоме місце у формуванні професійної компетентності майбутнього вчителя англійської мови. Дано визначення поняттю «культура мови» вчителя початкової школи та схарактеризовано його ознаки.Вказано на те, що основними складовими компетентності майбутнього викладача, котрі формуються у студентів закладів вищої освіти є наступні: знання, здібності, навички, індивідуально-психологічні особливості людини, акмеологічні варіанти. Зазначено, що в освітньому процесі провідною має бути пізнавальна діяльність студентів. Обґрунтовано можливість поєднання ставлення до розвитку особистості студента та формування практико-орієнтованої компетентності. Виділено, що професійна компетентність вчителя іноземної мови складається зі спеціальної компетентності (особистісні та непредметні знання, тобто знання загальноосвітніх і фундаментальних дисциплін), технологічних (методичних), управлінських (організаційних, ділових) та комунікаційних умінь. Характерною ознакою комунікативної компетентності науковці й педагоги-практики вважають органічне поєднання технологій навчання та лідерство, як засобів її реалізації.
ANÁLISE DE SUSTENTABILIDADE EM UMA UNIDADE DE BENEFICIAMENTO DE CARNE NO MUNICÍPIO DE TAQUARITINGA, SÃO PAULO
Authors: Da Silva Geisa Mamédio , Lemos Stella Vannucci 
Published: January 2023

O crescimento da pecuária especificamente no Brasil tem sido palco de algumas discussões, especialmente sobre a manutenção da sustentabilidade nos processos desde o abatimento até a produção de produtos cárneos. Diante dessa realidade, o objetivo dessa pesquisa é analisar o cumprimento dos Objetivos de Desenvolvimento Sustentável (ODSs) de uma unidade de beneficiamento de carne na cidade de Taquaritinga, interior do estado de São Paulo. A metodologia utilizada foi Revisão de Literatura e pesquisa em campo. Foram consultados artigos e realizadas análises com os responsáveis da beneficiadora para entendimento das práticas sustentáveis utilizadas. Os resultados mostram que a indústria de carne vem crescendo e ganhando cada vez mais destaque, no entanto é preciso que haja fiscalização já que essas atividades assim como muitas tendem a impactar o meio ambiente.
Cerebral tumor embolism from thyroid cancer treated by mechanical thrombectomy: illustrative case
Authors: Fujiwara Yuta , Hayashi Kentaro , Shibata Yohei , Furuta Tatsuya , Yamasaki Tomohiro , Yamamoto Kazuhiro , Uchimura Masahiro , Nakagawa Fumio , Kambara Mizuki , Nagai Hidemasa , Akiyama Yasuhiko 
Published: January 2023

BACKGROUND
Development in mechanical thrombectomy is progressing dramatically. Tumor embolism has been rarely reported on the basis of pathological study of the retrieved thrombus. Herein, the authors report a case of cerebral tumor embolism from advanced thyroid cancer, which was successfully treated with mechanical thrombectomy.

OBSERVATIONS
A 57-year-old man was diagnosed with thyroid cancer with multiple lung metastases and chemotherapy was planned. He experienced left hemiparesis and was bought to the emergency section of the authors’ hospital. Magnetic resonance angiography revealed right internal carotid artery occlusion and endovascular treatment was performed. Using a combination of aspiration catheter and stent retriever, white jelly-like embolus was retrieved. The pathological study demonstrated thyroid cancer embolism. Pulmonary vein invasion following lung metastasis of thyroid cancer was most presumably the cause of the tumor embolism.

LESSONS
Lung metastasis invading the pulmonary vein may be a cause of tumor embolism. Mechanical thrombectomy using a combination of stent retriever and aspiration catheter is effective in removing the tumor embolus and the pathological examination of the embolus is essential.
Leptomeningeal metastasis from neuroendocrine carcinoma of the cervix: illustrative case
Authors: Patterson John D. , Farach Andrew M. , Singh Monisha , Britz Gavin W. , Rostomily Robert C. 
Published: January 2023

BACKGROUND
Leptomeningeal carcinomatosis is a rare feature of metastasis that is characterized by thickening and increased contrast enhancement throughout the meninges of the central nervous system (CNS). Leptomeningeal disease (LMD) can occur as spread from primary CNS tumors or as a manifestation of metastasis to the CNS from primary tumor sites outside the CNS. Leptomeningeal disease is, however, rare in cervical cancer, in which metastasis occurs typically from local invasion.

OBSERVATIONS
The authors discuss the case of CNS metastasis with LMD from the rare neuroendocrine carcinoma of the cervix (NECC). Cervical cancer infrequently metastasizes to the CNS, but NECC is an aggressive variant with greater metastatic potential. Many of these patients will have previously received pelvic radiation, limiting their candidacy for craniospinal radiation for LMD treatment due to field overlap. This illustrative case documents the first known case of NECC CNS metastasis accompanied by LMD treated with intrathecal chemotherapy.

LESSONS
Reported is the first known case of NECC with CNS metastasis accompanied by LMD. The authors highlight the potentially critical role of intrathecal chemotherapy, in addition to radiotherapy, in treating leptomeningeal metastasis from cervical cancer.
Cerebrospinal fluid fistula as a complication of reverse transcriptase–polymerase chain reaction collection for the detection of coronavirus disease 2019: illustrative cases
Authors: Palavani Lucca B. , Andrade Camila V. F. , Andrade Renato A. , Alves Egmond , Barros Marcio Falchi , Barbieri João F. 
Published: January 2023

BACKGROUND
The most used method to detect coronavirus disease 2019 during the pandemic is reverse transcriptase–polymerase chain reaction with nasal swab. Despite being highly effective, the test does not leave the patient risk-free and can lead to serious complications. These can be traumatic nasal cerebrospinal fluid (CSF) fistula and its consequences, such as meningitis.

OBSERVATIONS
In this article, the authors present 4 case reports and a literature review. The following MeSH terms in the research were used: “CSF leak case report and covid 19.” Six results were found and after searching the references and keywords 16 articles were identified. By using them, the authors tried to clarify the etiology of the fistula, its influences, and complications.

LESSONS
The authors conclude that professionals must receive training, since CSF fistula originates from technical failure and lack of anatomical knowledge. The diagnosis cannot be neglected because it can bring complications to the patient’s health.
L5 mononeuritis, an uncommon cause of foot drop: illustrative case
Authors: Peselzon Oleg , Colditz Michael , Maclachlan Liam R. 
Published: January 2023

BACKGROUND
New-onset adult foot drop is commonly encountered in neurosurgical practice and has a broad differential, including radiculopathy, peroneal nerve palsy, demyelinating diseases, and central causes. Etiology is commonly identified with comprehensive history, examination, imaging, and investigations. Despite familiarity with the management of lumbar spondylosis and peroneal nerve compression causes, rare or uncommon presentations of nonsurgical causes are important to consider in order to avoid nonbeneficial surgery.

OBSERVATIONS
The authors report a very uncommon cause of foot drop: new-onset isolated L5 mononeuritis in a 61-year-old nondiabetic male. They provide a review of the etiology and diagnosis of foot drop in neurosurgical practice and detail pitfalls during workup and the strategy for its nonsurgical management.

LESSONS
Uncommon, nonsurgical causes for foot drop, even in the setting of degenerative lumbar spondylosis, should be considered during workup to reduce the likelihood of unnecessary surgical intervention. The authors review strategies for investigation of new-onset adult foot drop and relate these to an uncommon cause, an isolated L5 mononeuritis, and detail its clinical course and response to treatment.
Rapidly progressive diffuse leptomeningeal glioneuronal tumor in an adult female: illustrative case
Authors: Bao Jonathan , Sweeney Jared F. , Liu Yang , Genovese Frank L. , Adamo Matthew A. , Heller Robert S. 
Published: January 2023

BACKGROUND
Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare brain tumor only recently classified by the World Health Organization in 2016 and has few reports on its incidence in adults.

OBSERVATIONS
The authors describe a case of DLGNT presenting in a 47-year-old female with seizures, cranial neuropathies, and communicating hydrocephalus with rapid clinical progression. Workup demonstrated progressive leptomeningeal enhancement of the skull base, cranial nerves, and spine, and communicating hydrocephalus. Elevated serum rheumatological markers and early response to systemic corticosteroids and immunosuppressant therapy complicated the diagnosis. Multiple biopsy attempts were required to obtain diagnostic tissue. Pathology demonstrated hypercellularity surrounding leptomeningeal vessels with nuclear atypia, staining positive for GFAP, Olig2, S100, and synaptophysin. Molecular pathology demonstrated loss of chromosome 1p, BRAF overexpression but no rearrangement, and H3K27 mutation. Repeat cerebrospinal fluid (CSF) diversion procedures were required for hydrocephalus management due to high CSF protein content.

LESSONS
This report describes a rare, aggressive, adult presentation of DLGNT. Leptomeningeal enhancement and communicating hydrocephalus should raise suspicion for this disease process. Biopsy at early stages of disease progression is essential for early diagnosis and prompt treatment. Further study into the variable clinical presentation, histological and molecular pathology, and optimal means of diagnosis and management is needed.
Development of a Guided-Discovery Learning-Based Module to Improve Mathematical Problem-Solving Ability on Quadrangle Materials
Authors: Syafitri Resy Rahmi , Yenti Isra Nurmai , Fisher Dahlia , Efendi Riswan 
Published: January 2023

This study creates a valid, practical, and effective discovery-based module to improve students' ability to solve mathematical problems on quadrilateral content. This study employs the definition, design, and development phases of the research and development process. Validation sheets, student response questionnaires, and test questions were the study tools utilized. Techniques for data analysis using percentages and N-gain. Based on the findings of a study using guided exploration modules to enhance students' ability to solve quadrilateral problems in class VII SMP, which was valid with 76.92%. Results from the practicality test with practical categories were 79.37%. Student ability to solve mathematical problems shows effectiveness. The increase in the mathematical problem-solving ability of each student is in the medium category with an average N-gain of 0.48139.
Factors Associated to Pap Smear Cervical Screening Behavior among Midwives in Yogyakarta, Indonesia
Authors: Meilani Niken , Setiyawati Nanik 
Published: January 2023

Cervical cancer was the fourth most frequent cancer and approximately 90% of death occurred in low- and middle-income countries. Indonesia was the second country which has the most cervical cancer cases in the world. One recommended method of cervical cancer screening was pap smear test. This study aims to determine the factors that associated in midwive’s pap smear behavior. This study used a quantitative cross-sectional design. Subjects were 65 midwives in primary health care in Yogyakarta City. Combination Theory used Precede and Procede and Health Belief Model. This research analysis used univariate, bivariate and multivariate analysis. The results showed that there were 61.5% of midwives have did implementation of pap smear. There was a relationship between age (p=0.002), attitude (p=0.028), cost (p=0.208) and vulnerability (p=0.001) with pap smear behavior. There was no correlation between value (p=0.724), benefit (p=0.403) and severity (p=0.813) with pap smear behavior. Multivariate analysis showed that age was the most dominant factors affecting pap smear behavior (p-value 0.009; PR 26.903; CI 95% 2.251-321.490). Need to improved promotive efforts about pap smear among midwives and also women in general.
Tratamiento odontológico en pacientes pediátricos sometidos a tratamiento oncológico. Artículo de revisión.
Authors: Córdova-Vintimilla Juan José , Alvear-Córdova María Cristina 
Published: January 2023

A menudo los tratamientos contra el cáncer implican la combinación de terapias dirigidas a mejorar la supervivencia, la calidad de vida y preservar la dignidad del paciente. La resección quirúrgica, la radioterapia y la quimioterapia crean una morbilidad sustancial. Además, el cáncer genera una gran carga psicosocial y financiera para el paciente, sus familias y la sociedad en general. El sistema inmunológico del infante durante la terapia oncológica puede estar gravemente afectado, estas terapias específicas si bien son benéficas para el proceso de recuperación traen consigo complicaciones orales con el transcurso del tiempo, producto de la aplicación citotóxica de los fármacos. La intervención dental previa, durante y después de la terapia, cumple un rol en la reducción de la incidencia y la gravedad de las complicaciones. Ante este contexto el objetivo principal de esta revisión es maximizar la calidad de vida del paciente pediátrico a través de la información actual disponible en las bases de datos digitales para lo cual se realizó una búsqueda integral. Esta revisión está dedicada a la discusión de la rehabilitación oral del paciente oncológico infantil, concluye que el papel del odontopediatra es un esfuerzo coordinado y multidisciplinario que requiere gran atención en los aspectos médicos, quirúrgicos y humanísticos del bienestar del paciente. Las mejoras en el tratamiento de la mucositis, las infecciones orales y la xerostomía podrían proporcionar un gran beneficio para la calidad de vida.
Patologías adquiridas del territorio maxilofacial que manifiestan asimetría mandibular. Revisión de la literatura.
Authors: Munizaga Naveillan María Soledad , Durán Barría Francisca Paola , Alvarez Palacios Eduardo Antoni 
Published: January 2023

La asimetría facial se caracteriza por la presencia de una desarmonía entre ambos lados de la cara. Se manifiestan más comúnmente en el tercio inferior de la cara (mandíbula y mentón), debido a que presentan periodos de crecimiento mayores y una mayor área de soporte.
Objetivo: El objetivo de esta revisión es identificar cuales son las principales patologías óseas adquiridas que manifiestan asimetría mandibular, resaltar los aspectos que el ortodoncista debe tener en cuenta, sus efectos en el tratamiento y además de señalar algunas opciones terapéuticas.
Método: Se realizó una búsqueda en PubMed desde el año 2000 en adelante. Se seleccionaron artículos en ingles y español que se pudieran obtener en formato completo.
Resultados: La información obtenida se clasifico en 5 secciones (etiología y clasificación, manifestaciones clínicas, implicancias clínicas, diagnóstico y tratamiento).
Conclusiones: Los resultados obtenidos en esta investigación nos permiten obtener una guía para la toma de decisiones en la practica clínica y además diferenciar las posibles patologías involucradas en la manifestación de una asimetría mandibular.
Palabras claves: facial asymmetry, mandibular asymmetry, skeletal, humans, diagnosis.
Efecto de las partículas de Nanohidroxiapatita al 20% de dentríficos en el sellado de túbulos dentinarios. Estudio in-vitro
Authors: Gordon Diego , Farfán-Mera Karina 
Published: January 2023

La sensibilidad dental es un síntoma común en la práctica estomatológica. El porcentaje de población adulta afectada varía entre el 40 y 60%, siendo frecuentemente hallada en caras vestibulares de caninos y premolares. Existen varios métodos para tratar la hipersensibilidad dental, entre ellos, el uso de nanotecnología ha permitido mejorar las propiedades de los materiales dentales. Objetivo: Evaluar el efecto de las nanopartículas de hidroxiapatita al 20 % en dentífricos para sellado de túbulos dentinarios. Materiales y Métodos: Se utilizaron 40 discos de dentina con 2mm de espesor, divididos aleatoriamente en 4 grupos (n=10), Grupo A control; Grupo B con 20% de nanohidroxiapatita y partícula de 356 nm; Grupo C 20% y partícula 420 nm; Grupo D 20% y partícula 1817nm. Los discos de dentina fueron pulidos con discos (3M™ Sof-Lex). El barrillo dentinario fue eliminado con ácido cítrico al 10% por 120 segundos. Cada grupo fue cepillado (Oral B Vitality™) A 7600 rpm con 0.2 gr de dentífrico con partículas de nanohidroxiapatita por 2 min dos veces al día durante 7 días. La prueba de rugosidad se realizó con el Perfilómetro de Contacto Bruker Dektak XT, con área de escaneo de 3.5 μm lineales en 120 segundos. Las muestras fueron analizadas con el Microscopio Electrónico de Barrido (SEM) Tescan Mira 3. Resultados: Los valores de rugosidad en los grupos B,C, D disminuyeron frente al grupo control. Conclusiones: las partículas de nanohidroxiapatita según su tamaño tienen eficacia muy importante en la obliteración de los túbulos dentinarios.
Palabras Claves: Sensibilidad dental, nanhidroxiapatita, dentífrico, nanotecnología.