bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition Metal Complexes as Antimalarial Agents: A Review
Authors: Mandal Apurba , Kushwaha Rajesh , Mandal Arif Ali , Bajpai Sumit , Yadav Ashish Kumar , Banerjee Samya 
Published: July 2023

AbstractIn antimalarial drug development research, overcoming drug resistance has been a major challenge for researchers. Nowadays, several drugs like chloroquine, mefloquine, sulfadoxine, and artemisinin are used to treat malaria. But increment in drug resistance has pushed researchers to find novel drugs to tackle drug resistance problems. The idea of using transition metal complexes with pharmacophores as ligands/ligand pendants to show enhanced antimalarial activity with a novel mechanism of action has gained significant attention recently. The advantages of metal complexes include tunable chemical/physical properties, redox activity, avoiding resistance factors, etc. Several recent reports have successfully demonstrated that the metal complexation of known organic antimalarial drugs can overcome drug resistance by showing enhanced activities than the parent drugs. This review has discussed the fruitful research works done in the past few years falling into this criterion. Based on transition metal series (3d, 4d, or 5d), the antimalarial metal complexes have been divided into three broad categories (3d, 4d, or 5d metal‐based), and their activities have been compared with the similar control complexes as well as the parent drugs. Furthermore, we have also commented on the potential issues and their possible solution for translating these metal‐based antimalarial complexes into the clinic.
The impact of the COVID‐19 pandemic on the diagnosis and treatment of skin cancers, a mini review
Authors: Aryanian Zeinab , Balighi Kamran , Goodarzi Azadeh , Sadeghi Nia Ali , Afshar Zeinab Mohseni , Hatami Parvaneh 
Published: July 2023

AbstractBackgroundThe SARS‐Cov‐2 pandemic has caused dermatologists around the world to adapt their practice in the aim of protecting patients with special clinical conditions such as those having skin cancers or premalignant conditions and some diagnostic or therapeutic programs would be suspended due to being infected to SARS‐CoV‐2. We focused the existing data in this regard through searching on PubMed, Google Scholar, and Scopus and tried to summarize recommendations for treating this group of patients in COVID era to provide a practical guide for clinicians.Recent findingsThe number of diagnosed skin cancers dropped significantly since the beginning of the pandemic, specially in the peaks of various variants of the SARS‐CoV‐2 infection. The new guidelines allowed even a 3‐month delay in excision and recommended surgery for non‐melanoma growing skin cancers.ConclusionDermatologists should perform a careful, individualized risk–benefit assessment for their patients and consider some changes in routine protocols such as having a delayed diagnostic or therapeutic intervention.
Autologous natural killer cells as a promising immunotherapy for locally advanced colon adenocarcinoma: Three years follow‐up of resectable case
Authors: Bagus Budhi Ida 
Published: July 2023

AbstractBackgroundOver the last decade, a new modality of immunotherapy has been announced, with the expectation of better long‐term clinical outcomes and disease‐free survival after the definitive surgical treatment of colon cancer. Natural killer (NK) cells as part of cellular therapy in immunotherapy have the potential effect as an adjuvant therapy for locally advanced and metastasized colorectal adenocarcinoma. We would evaluate the clinical outcome of autologous NK cell therapy for resectable colon cancer.CaseA 64‐year‐old woman presented with a transverse colon tumor‐related partial intestinal obstruction and a history of bloody diarrhea. A transverse colectomy has been done, and the pathology report reported adenocarcinoma of the transverse colon and positive lymph node involvement (TNM stage III). The patient had R0 resection status. A PET scan was done 6 months later, with positive lymph node glucose uptake at mesocolic. NK cell therapy was administered for 2 cycles with a 3‐month interval, and PET scan follow‐up was done 3 years after resection; no more glucose uptake was found, and the patients tolerated the therapy well with no immune‐related adverse effects reported.ConclusionAs a new modality in immunotherapy strategies for locally advanced colon adenocarcinoma, particularly in cases unsuitable for standard chemotherapeutic treatment, autologous NK cells have a promising effect and are feasible and well tolerated in our clinical practice.
Colossal Stability of SiB11(BO)12−: An Implication as Potential Electrolyte in High‐Voltage Alkali‐ion Battery
Authors: Kumar Kushwaha Anoop , Soumya Jena Sushri , Ranjan Sahoo Mihir , Das Debashish , Kumar Nayak Saroj 
Published: July 2023

AbstractHigh‐voltage alkali metal‐ion batteries (AMIBs) require a non‐hazardous, low‐cost, and highly stable electrolyte with a large operating potential and rapid ion conductivity. Here, we have reported a halogen‐free high‐voltage electrolyte based on SiB11(BO)12−. Because of the weak π‐orbital interaction of −BO as well as the mixed covalent and ionic interaction between SiB11‐cage and −BO ligand, SiB11(BO)12− has colossal stability. SiB11(BO)12− possesses extremely high vertical detachment energy (9.95 eV), anodic voltage limit (∼10.05 V), and electrochemical stability window (∼9.95 V). Furthermore, SiB11(BO)12− is thermodynamically stable at high temperatures, and its large size allows for faster cation movement. The alkali salts MSiB11(BO)12 (M=Li, Na, and K) are easily dissociated into ionic components. Electrolytes based on SiB11(BO)12− greatly outperform commercial electrolytes. In short, SiB11(BO)12−‐based compound is demonstrated to be a high‐voltage electrolyte for AMIBs.
Enhancing youth's retention in potato farming enterprise through consortium agribusiness models in Tanzania
Authors: Ngozi Semeni , Feleke Shiferaw 
Published: July 2023

AbstractThe future of African youth probably lies in agriculture; however, this can be realized by making agriculture both profitable and attractive to young people. The importance of increasing youth involvement in agricultural value chains is primarily to sustain food production and secondly to reduce youth unemployment. Youth can be involved in various segments of agriculture and food value chains including production, post‐harvest handling, distribution, value addition, and marketing. In Tanzania, Agri‐Hub networks promote entrepreneurship by linking the youth to processing, markets, agricultural input dealers, extension services, and the promotion of existing and emerging agribusiness opportunities. It is believed that market access is critical in igniting an agricultural transformation that will upgrade African farmers (youth) from subsistence to business‐focused production. Kilimo Trust in Tanzania has been employing an innovative consortium agribusiness model to efficiently link youth farmers to outputs and inputs markets. The model helped these farmers in accessing sustainable, profitable, and structured input and output markets, particularly those engaged in potato production. Thus, a study was designed to find how the consortium business model influences youth engagement and retention in potato farming enterprises. The study employed a multistage sampling technique to collect data from 144 participants and 120 non‐participants of the consortium business model. A questionnaire and key informant interviews were employed to collect data. Data collected were analyzed using descriptive statistics, content analysis, and propensity score matching. The findings of this study reveal that young small‐scale farmers participated in collaborative procurement of inputs and marketing of potatoes and attended training during project implementation. The results further show that participation in the consortium business model has a positive and significant effect on youth's retention in potato farming enterprises. Youth potato farmers participating in the consortium business model have higher profit per hectare (2,392,326.5TZS/Ha) than youth in groups not utilizing the consortium business model to the group membership (2,170,405 TZS/Ha). Therefore, this study recommends that governments support policies that will facilitate the establishment and strengthening of the consortium business models. This will assist in sustainably engaging and retaining youth in agriculture through increased productivity and profit.
A 3.83–5.55 GHz high frequency resolution DCO with optimized switched‐capacitor ladder and low‐coupled eight‐shaped transformer
Authors: Zou Wei , Li Lei , Cheng Zhengwang , Zhang Li , Wang Mei , Ma Xinguo , Zou Xuecheng 
Published: July 2023

SummaryA high frequency resolution digitally controlled oscillator (DCO) is proposed for wireless transceivers, in which the scheme adopts an optimized cascaded differential switched‐capacitor (SC) ladder and a low‐coupled eight‐shaped transformer. The frequency resolution is further improved by the low electromagnetic coupling effect between the primary and secondary coils of the on‐chip transformer, thus reducing quantization noise and phase noise. An eight‐shaped transformer designed using two coils cross‐connected each other is adopted to reduce the magnetic coupling and frequency pulling. The proposed DCO is implemented in a TSMC 180‐nm CMOS process, and a tuning range of 36.7% from 3.83 to 5.55 GHz with a frequency resolution of 17 kHz is achieved. The phase noise is −120.29 dBc/Hz at 1 MHz offset from the 3.83 GHz carrier frequency. The DCO consumes 9.26 mA from a 1.8 V supply, while the figure of merit with tuning range is −191 dBc/Hz. The chip size is 0.294 mm2.
A pregnancy‐specific Glucose management indicator derived from continuous glucose monitoring in pregnant women with type 1 diabetes
Authors: Ling Ping , Yang Daizhi , Wang Chaofan , Zheng Xueying , Luo Sihui , Yang Xubin , Deng Hongrong , Xu Wen , Yan Jinhua , Weng Jianping 
Published: July 2023

AbstractObjectiveGlucose management indicator (GMI) is a core metric derived from continuous glucose monitoring (CGM) and is widely used to evaluate glucose control in patients with diabetes. No study has explored the pregnancy‐specific GMI. This study aimed to derive a best‐fitting model to calculate GMI from mean blood glucose (MBG) obtained from CGM among pregnant women with type 1 diabetes mellitus (T1DM).MethodsA total of 272 CGM data and corresponding laboratory HbA1c from 98 pregnant women with T1DM in the CARNATION study were analysed in this study. Continuous glucose monitoring data were collected to calculate MBG, time‐in‐range (TIR), and glycaemic variability parameters. The relationships between the MBG and HbA1c during pregnancy and postpartum were explored. Mix‐effect regression analysis with polynomial terms and cross‐validation method was conducted to investigate the best‐fitting model to calculate GMI from MBG obtained by CGM.ResultsThe pregnant women had a mean age of 28.9 ± 3.8 years, with a diabetes duration of 8.8 ± 6.2 years and a mean body mass index (BMI) of 21.1 ± 2.5 kg/m2. The HbA1c levels were 6.1 ± 1.0% and 6.4 ± 1.0% during pregnancy and at postpartum (p = 0.024). The MBG levels were lower during pregnancy than those at postpartum (6.5 ± 1.1 mmol/L vs. 7.1 ± 1.5 mmol/L, p = 0.008). After adjusting the confounders of haemoglobin (Hb), BMI, trimesters, disease duration, mean amplitude of glycaemic excursions and CV%, we developed a pregnancy‐specific GMI‐MBG equation: GMI for pregnancy (%) = 0.84–0.28* [Trimester] + 0.08 * [ BMI in kg/m2 ] + 0.01 * [Hb in g/mL] + 0.50 * [MBG in mmol/L].ConclusionsWe derived a pregnancy‐specific GMI equation, which should be recommended for antenatal clinical care.Clinical trial registry numberChiCTR1900025955.
Shaking table test and cumulative deformation evaluation analysis of a tunnel across the hauling sliding surface
Authors: Pai Lifang , Wu Honggang , Wang Xu 
Published: July 2023

AbstractTo explore the cumulative deformation effect of the dynamic response of a tunnel crossing the hauling sliding surface under earthquakes, the shaking table test was conducted in this study. Combined with the numerical calculations, this study proposed magnification of the Arias intensity (MIa) to characterize the overall local deformation damage of the tunnel lining in terms of the deformation characteristics, frequency domain, and energy. Using the time‐domain analysis method, the plastic effect coefficient (PEC) was proposed to characterize the degree of plastic deformation, and the applicability of the seismic cumulative failure effect (SCFE) was discussed. The results show that the low‐frequency component (f1 and f2 ≤ 10 Hz) and the high‐frequency component (f3 and f4 > 10 Hz) acceleration mainly cause global and local deformation of the tunnel lining. The local deformation caused by the high‐frequency wave has an important effect on the seismic damage of the lining. The physical meaning of PEC is more clearly defined than that of the residual strain, and the SCFE of the tunnel lining can also be defined. The SCFE of the tunnel lining includes the elastic deformation effect stage (<0.15g), the elastic–plastic deformation effect stage (0.15g–0.30g), and the plastic deformation effect stage (0.30g–0.40g). This study can provide valuable theoretical and technical support for the construction of traffic tunnels in high‐intensity earthquake areas.
Cyclopentadienyl Complexes of IrIII for Attempted C−D Bond Activation
Authors: Robinson Robert D. , Kaminsky Werner , Scepaniak Jeremiah J. 
Published: July 2023

AbstractThe complexes Cp(MeIm)IrI2 and CpMe4(MeIm)IrCl2 have been prepared and subsequently methylated to form Cp(MeIm)IrMe2 and CpMe4(MeIm)IrMe2 (Cp=η5‐C5H5, CpMe4=η5‐C5HMe4, MeIm=1,3‐dimethylimidazol‐2‐ylidene). We attempted unsuccessfully to use the dimethyl complexes to study C−D bond activation via methyl‐group abstraction. Protonation with one equivalent of a weak acid, such as 2,6‐dimethylpyridinium chloride, affords methane and IrIII methyl chloride complexes. 1H‐NMR experiments show addition of pyridinium [BArF20]− (BArF20=[B(C6F5)4]−) to the dimethyl species forms [Cp(MeIm)IrMe(py)]+[BArF20]− (py=pyridine) or [CpMe4(MeIm)IrMe(py)]+[BArF20]− respectively, alongside methane, while use of the [BArF20]− salts of more bulky 2,6‐dimethylpyridinium and 2,6‐di‐tert‐butylpyridinium gave an intractable mixture. Likewise, the generation of 16 e− species [CpMe4(MeIm)IrMe]+[BArF20]− or [Cp(MeIm)IrMe]+[BarF20]− at low temperature using 2,6‐dimethylpyridinium or 2,6‐di‐tert‐butylpyridinium in thawing C6D6 or toluene‐d8 formed an intractable mixture and did not lead to C−D bond activation. X‐ray structures of several IrIII complexes show similar sterics as that found for the previously reported Cp* analogue.
Pd(II)‐Catalyzed Benzimidazole‐Assisted Annulation of 3‐(1H‐Benzo[d]imidazol‐2‐yl)‐2H‐chromen‐2‐one: Access to Imidazo[1,2‐a]chromeno[3,4‐c]pyridine
Authors: Singla Dinesh , Luxami Vijay , Paul Kamaldeep 
Published: July 2023

AbstractPalladium‐catalyzed [4+2] oxidative annulation of coumarin‐benzimidazoles with olefins for the synthesis of polycyclic aromatic hydrocarbons have been achieved. This synthetic protocol gives access to a wide range of structurally distinct imidazo[1,2‐a]chromeno[3,4‐c]pyridines in moderate to good yield with wide functional group tolerance. Further, photophysical properties of annulated scaffolds have been examined, which discloses their interesting solvatochromic emission behaviors.
Capillary electrophoresis on‐line hyphenated with mass spectrometry for analysis of insulin‐like growth factor‐1 in pharmaceutical preparations
Authors: Tomašovský Radovan , Opetová Martina , Havlikova Jana , Mikuš Peter , Maráková Katarína 
Published: July 2023

AbstractInsulin‐like growth factor‐1 (IGF‐1) is a 70‐amino acid single‐chain polypeptide, which has found application in diagnostics as a biomarker of growth hormone disorders and as a therapy for growth failure in children and adolescents. Due to its strong anabolic effects, it is often abused by athletes for doping purposes. Here, we developed an on‐line hyphenated method based on capillary zone electrophoresis (CZE) and triple quadrupole mass spectrometry (MS) detection with electrospray ionization (CZE–electrospray ionization source–MS [CZE–ESI–MS]) for the determination of IGF‐1 in pharmaceutical matrices. We achieved a highly efficient, accurate, repeatable, sensitive, and selective analysis of IGF‐1 with favorable migration times (<15 min). Optimized and validated CZE–ESI–MS method was successfully applied for the determination of IGF‐1 in injectable solutions (Increlex®), and its presence was also confirmed in nutritional preparations (tablets and liquid colostrum). This is the first validated CZE–ESI–MS method for the determination of IGF‐1 in pharmaceutical matrices revealing the potential of capillary electrophoresis for its use in drug quality control laboratories with benefits, such as high separation efficiency, high‐speed analysis, low sample consumption, as well as environmental and cost aspects.
One‐step supramolecular pre‐organizational synthesis of copper‐doped porous carbon nitride for high photocatalytic nitrogen fixation
Authors: Gao Ping , Rong Xinshan , Zhang Shixian , Sun Ting , Liu Jun , Qiu Xuchun , Zhou Xiangtong , Wu Zhiren , Wei Jing 
Published: July 2023

AbstractSolar‐driven reduction of nitrogen to ammonia is a promising green approach and is considered as a sustainable alternative to the Haber–Bosch process. Carbon nitride (g‐C3N4) is an ideal non‐metallic semiconductor photocatalyst for photocatalytic N2 reduction reaction (p‐NRR). In this work, we designed a simple supramolecular self‐assembly method to prepare copper‐doped porous graphitic nitride (Cu@pg‐C3N4) photocatalysts. The synergistic semiconductor and metal interactions enabled the obtained Cu@pg‐C3N4 to achieve larger specific surface area, more efficient photogenerated carrier separation, and stronger photoreduction ability. The specific surface area of Cu@pg‐C3N4 increased from 5.69 to 75.76 μmol/L, exposing more active sites compared to bulk g‐C3N4. The NH4+ production rate of the obtained Cu@pg‐C3N4 was 150.47 μmol/L, which is 20 times higher than that of the bulk carbon nitride, exhibiting excellent N2 photofixation ability. These findings highlight the significant progress that can be achieved by metal supramolecular network modification strategies in harnessing the potential of carbon nitride for photocatalytic reduction applications.
Cloud‐Enabled Handheld NIR Spectroscopy: A Transformative Approach for Real‐Time Forensic Analysis of Cannabis Specimens
Authors: Coppey Florentin , Schelling Cédric , Veuthey Jean‐Luc , Esseiva Pierre 
Published: July 2023

AbstractIn the past few years, there has been significant interest within the forensic community regarding the deployment of portable solutions that provide real‐time results. This article introduces an innovative technology or technology architecture that enables the integration of a handheld device, specifically, Viavi MicroNIR, with a cloud‐based system. This cloud system encompasses a server responsible for data processing and a mobile application acting as a user interface.To demonstrate the transformative impact of this technology on field operators, the analysis of cannabis specimens has been utilized. System's capacity to distinguish between CBD‐type and THC‐type cannabis has been particularly highlighted, along with the remarkable congruence observed between the near‐infrared (NIR) spectra and the reference analytical method involving ultra‐high‐performance liquid chromatography (UHPLC)The article will present the advantages of this application primarily focusing on its potential to alleviate the burden on laboratories by expediting routine illicit drug analysis. Viavi MicroNIR technology provides laboratory personnel with additional time to handle more complex cases, thereby enhancing overall efficiency.
Mechanism of immune escape mediated by receptor tyrosine kinase KIT in thyroid cancer
Authors: Luo Zhen , Xu Jin , Xu Dayong , Xu Jiaojiao , Zhou Rongjun , Deng Keping , Chen Zheng , Zou Fang , Yao Libo , Hu Yuqin 
Published: July 2023

AbstractObjectiveThyroid cancer (TC) is one of the fastest‐growing malignant tumors. This study sought to explore the mechanism of immune escape mediated by receptor tyrosine kinase (KIT) in TC.MethodsThe expression microarray of TC was acquired through the GEO database, and the difference analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were carried out. KIT levels in TC cell lines (K1/SW579/BCPAP) and human normal thyroid cells were detected using reverse transcription quantitative polymerase chain reaction and western blot analysis. TC cells were transfected with overexpressed (oe)‐KIT and CD8+ T cells were cocultured with SW579 cells. Subsequently, cell proliferation, migration, and invasion abilities, CD8+ T cell proliferation, cytokine levels (interferon‐γ [IFN‐γ]/tumor necrosis factor‐α [TNF‐α]) were determined using colony formation assay, Transwell assays, flow cytometry, and enzyme‐linked immunosorbent assay. The phosphorylation of MAPK pathway‐related protein (ERK) was measured by western blot analysis. After transfection with oe‐KIT, cells were treated with anisomycin (an activator of the MAPK pathway), and the protein levels of p‐ERK/ERK and programmed death‐ligand 1 (PD‐L1) were detected.ResultsDifferentially expressed genes (N = 2472) were obtained from the GEO database. KIT was reduced in TC samples and lower in tumor cells than those in normal cells. Overexpression of KIT inhibited immune escape of TC cells. Specifically, the proliferation, migration, and invasion abilities of TC cells were lowered, the proliferation level of CD8+ T cells was elevated, and IFN‐γ and TNF‐α levels were increased. KIT inhibited the activation of the MAPK pathway in TC cells and downregulated PD‐L1.ConclusionKIT suppressed immune escape of TC by blocking the activation of the MAPK pathway and downregulating PD‐L1.
Mental health and sleep quality of low‐income mothers of one‐year‐olds during the COVID‐19 pandemic
Authors: Premo Elizabeth M. , Magnuson Katherine A. , Lorenzo Nicole E. , Fox Nathan A. , Noble Kimberly G. 
Published: July 2023

AbstractThe COVID‐19 pandemic and subsequent social restrictions created an unprecedented context for families raising young children. Although studies have documented detrimental effects of the pandemic on maternal well‐being, less is known about how the pandemic specifically impacted low‐income mothers. We examined depression, anxiety, and sleep quality among low‐income mothers of one‐year‐olds during the early months of the pandemic using data from the Baby's First Years study. Focusing on the control group (n = 547), we compared mothers interviewed before March 14th, 2020 (n = 342) to mothers interviewed between March 14th and June 30th, 2020 (n = 205) to determine whether the pandemic was associated with differences in mental health and sleep quality. Mothers were recruited from four cities in the United States, and most of the sample identified as Hispanic (42.2%) or Black, non‐Hispanic (38.6%). We found that mothers interviewed during the pandemic reported better mental health and sleep quality. While we cannot speak to longer‐term impacts of the pandemic, it is possible low‐income mothers experienced relief from daily stressors during the initial shelter‐in‐place orders, which may have led to improvements in well‐being. These results have implications for understanding how complex life stressors influence mental health and sleep quality among low‐income mothers raising young children.