bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depressive primary care patients’ assessment of received collaborative care
Authors: Lukaschek K. , Beltz C. , Rospleszcz S. , Schillok H. , Falkai P. , Margraf J. , Gensichen J. 
Published: February 2023

AbstractThe “Patient Assessment of Chronic Illness Care” (PACIC) is a tool for evaluating outpatient health service for patients with chronic diseases. Our aim was to analyze the association between PACIC scores of primary care patients with depression and patients’ or patients’ general practitioners’ (GPs) characteristics. In a data set including depressive primary care patients (N = 280) the association of patient characteristics (sex, age, depressive symptom severity, suicidal ideation) with PACIC scores were assessed by linear regression models. The association between GPs’ characteristics (type, location of practice; age, qualification of practitioner) and PACIC scores was assessed by linear mixed models with individual practices as random effects. Patient Health Questionnaire (PHQ-9) scores at 12 months follow up and changes in PHQ-9 scores from baseline to follow up were significantly positive associated with higher PACIC scores (beta = 0.67, 95%-CI [0.02, 1.34]). PACIC scores were not associated with patients’ sex (p = 0.473) or age (p = 0.531). GP’s age was negatively associated with PACIC scores (p = 0.03). In conclusion, in patients with depression, the PACIC is independent from patients’ and GPs’ characteristics. The PACIC may be appropriate to assess patient-perspective on depression services in primary care.
Theoretical and experimental study of the “superelastic collision effects” used to excite high-g shock environment
Authors: Duan Zhengyong , Zeng Qihang , Tang Dayong , Peng Yingchun 
Published: February 2023

AbstractThe excitation technology for high-g-level shock environment experiments is currently a topic of interest, for which velocity amplification by collisions of vertically stacked bodies has been used to develop high-g shock tests with great success. This study investigated the superelastic collision effects generated during high-velocity one-dimensional three-body impacts. Theoretical formulae were derived in brief for an analytical investigation of the collisions. Four experiments were performed with different initial velocities obtained from free-falls from different heights. Velocity gains larger than 5 were obtained for the three-body collisions, and coefficients of restitution larger than 2.5 were observed for the second impact. The experimental results well verified the existence of superelastic collision effects in the one-dimensional three-body impacts.
The AP-1 transcription factor Fosl-2 drives cardiac fibrosis and arrhythmias under immunofibrotic conditions
Authors: Stellato Mara , Dewenter Matthias , Rudnik Michal , Hukara Amela , Özsoy Çagla , Renoux Florian , Pachera Elena , Gantenbein Felix , Seebeck Petra , Uhtjaerv Siim , Osto Elena , Razansky Daniel , Klingel Karin , Henes Joerg , Distler Oliver , Błyszczuk Przemysław , Kania Gabriela 
Published: February 2023

AbstractFibrotic changes in the myocardium and cardiac arrhythmias represent fatal complications in systemic sclerosis (SSc), however the underlying mechanisms remain elusive. Mice overexpressing transcription factor Fosl-2 (Fosl-2tg) represent animal model of SSc. Fosl-2tg mice showed interstitial cardiac fibrosis, disorganized connexin-43/40 in intercalated discs and deregulated expression of genes controlling conduction system, and developed higher heart rate (HR), prolonged QT intervals, arrhythmias with prevalence of premature ventricular contractions, ventricular tachycardias, II-degree atrio-ventricular blocks and reduced HR variability. Following stimulation with isoproterenol Fosl-2tg mice showed impaired HR response. In contrast to Fosl-2tg, immunodeficient Rag2−/−Fosl-2tg mice were protected from enhanced myocardial fibrosis and ECG abnormalities. Transcriptomics analysis demonstrated that Fosl-2-overexpression was responsible for profibrotic signature of cardiac fibroblasts, whereas inflammatory component in Fosl-2tg mice activated their fibrotic and arrhythmogenic phenotype. In human cardiac fibroblasts FOSL-2-overexpression enhanced myofibroblast signature under proinflammatory or profibrotic stimuli. These results demonstrate that under immunofibrotic conditions transcription factor Fosl-2 exaggerates myocardial fibrosis, arrhythmias and aberrant response to stress.
De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae
Authors: Han Jianing , Li Sijin 
Published: February 2023

AbstractBerberine is an extensively used pharmaceutical benzylisoquinoline alkaloid (BIA) derived from plants. Microbial manufacturing has emerged as a promising approach to source valuable BIAs. Here, we demonstrated the complete biosynthesis of berberine in Saccharomyces cerevisiae by engineering 19 genes including 12 heterologous genes from plants and bacteria. Overexpressing bottleneck enzymes, fermentation scale-up, and heating treatment after fermentation increased berberine titer by 643-fold to 1.08 mg L-1. This pathway also showed high efficiency to incorporate halogenated tyrosine for the synthesis of unnatural BIA derivatives that have higher therapeutical potentials. We firstly demonstrate the in vivo biosynthesis of 11-fluoro-tetrahydrocolumbamine via nine enzymatic reactions. The efficiency and promiscuity of our pathway also allow for the simultaneous incorporation of two fluorine-substituted tyrosine derivatives to 8, 3’-di-fluoro-coclaurine. This work highlights the potential of yeast as a versatile microbial biosynthetic platform to strengthen current pharmaceutical supply chain and to advance drug development.
A combined experimental and theoretical study of RuO2/TiO2heterostructures as a photoelectrocatalyst for hydrogen evolution
Authors: Kaikhosravi Mohammad , Hadadzadeh Hassan , Farrokhpour Hossein , Salimi Abdollah , Mohtasham Hamed , Foelske Annette , Sauer Markus 
Published: February 2023

An experimental and theoretical study of RuO2/TiO2 heterostructures as photoelectrocatalysts for hydrogen evolution reaction (HER).
Thermally activated bipyridyl-based Mn-MOFs with Lewis acid–base bifunctional sites for highly efficient catalytic cycloaddition of CO2 with epoxides and Knoevenagel condensation reactions
Authors: Xu Zhen , Zhao Ya-Yu , Chen Le , Zhu Cai-Yong , Li Peng , Gao Wei , Li Ji-Yang , Zhang Xiu-Mei 
Published: February 2023

A bipyridyl-based Mn2+-organic framework was synthesized. Activated Mn-MOF-1 could serve as an efficient heterogeneous catalyst for the cycloaddition of CO2 with epoxides and Knoevenagel condensation reactions.
Marginal and Canonical Babbling in 10 Infants at Risk for Cerebral Palsy
Authors: Long Helen L. , Hustad Katherine C. 
Published: February 2023

Purpose:
This study is a preliminary quantification and characterization of the development of marginal and canonical syllable patterns in 10 infants at risk for cerebral palsy (CP).

Method:

We calculated marginal and canonical babbling ratios from parent–infant laboratory recordings of 10 infants at two time points, approximately 13 and 16 months of age. The frequency and diversity of labial, coronal, and velar types of marginal and canonical syllables were also examined. Differences across three outcome groups were compared: infants later diagnosed with CP (
n
= 3, CP group), risk of CP due to ongoing gross motor delays (
n
= 4, risk group), and current typically developing status with resolved gross motor delays (
n
= 3, TDx group). Performance on the Mullen Scales was included for perspective on cognitive development.

Results:
Higher marginal syllable ratios were observed in the CP and risk groups than the TDx group. An increasing canonical syllable ratio across the two ages was consistently observed in the TDx group. The TDx group produced a greater frequency and diversity of canonical syllable types than the risk and CP groups, and of marginal syllable types than the CP group.

Conclusions:
This study offers preliminary support for the possibility that speech motor impairment in infants with CP have the potential to be observed and quantified early in vocal development prior to the expected onset of first words. Prolonged rates of marginal syllable forms may be suggestive of speech motor impairment; however, additional longitudinal outcome data over a longer time course and a larger sample of infants are needed to provide further support for this possibility.
The Gaia-ESO Survey: Chemical evolution of Mg and Al in the Milky Way with machine learning
Authors: Ambrosch M. , Guiglion G. , Mikolaitis Š. , Chiappini C. , Tautvaišienė G. , Nepal S. , Gilmore G. , Randich S. , Bensby T. , Bayo A. , Bergemann M. , Morbidelli L. , Pancino E. , Sacco G. G. , Smiljanic R. , Zaggia S. , Jofré P. , Jiménez-Esteban F. M. 
Published: February 2023

Context. To take full advantage of upcoming large-scale spectroscopic surveys, it will be necessary to parameterize millions of stellar spectra in an efficient way. Machine learning methods, especially convolutional neural networks (CNNs), will be among the main tools geared at achieving this task.
Aims. We aim to prepare the groundwork for machine learning techniques for the next generation of spectroscopic surveys, such as 4MOST and WEAVE. Our goal is to show that CNNs can predict accurate stellar labels from relevant spectral features in a physically meaningful way. The predicted labels can be used to investigate properties of the Milky Way galaxy.
Methods. We built a neural network and trained it on GIRAFFE spectra with their associated stellar labels from the sixth internal Gaia-ESO data release. Our network architecture contains several convolutional layers that allow the network to identify absorption features in the input spectra. The internal uncertainty was estimated from multiple network models. We used the t-distributed stochastic neighbor embedding tool to remove bad spectra from our training sample.
Results. Our neural network is able to predict the atmospheric parameters Teff and log(g) as well as the chemical abundances [Mg/Fe], [Al/Fe], and [Fe/H] for 36 904 stellar spectra. The training precision is 37 K for Teff, 0.06 dex for log(g), 0.05 dex for [Mg/Fe], 0.08 dex for [Al/Fe], and 0.04 dex for [Fe/H]. Network gradients reveal that the network is inferring the labels in a physically meaningful way from spectral features. We validated our methodology using benchmark stars and recovered the properties of different stellar populations in the Milky Way galaxy.
Conclusions. Such a study provides very good insights into the application of machine learning for the analysis of large-scale spectroscopic surveys, such as WEAVE and 4MOST Milky Way disk and bulge low- and high-resolution (4MIDABLE-LR and -HR). The community will have to put substantial efforts into building proactive training sets for machine learning methods to minimize any possible systematics.
Multiplicity of northern bright O-type stars with optical long baseline interferometry
Authors: Lanthermann C. , Le Bouquin J.-B. , Sana H. , Mérand A. , Monnier J. D. , Perraut K. , Frost A. J. , Mahy L. , Gosset E. , De Becker M. , Kraus S. , Anugu N. , Davies C. L. , Ennis J. , Gardner T. , Labdon A. , Setterholm B. , ten Brummelaar T. , Schaefer G. H. 
Published: February 2023

Context. The study of the multiplicity of massive stars gives hints on their formation processes and their evolutionary paths, which are still not fully understood. Large separation binaries (>50 milliseconds of arc, mas) can be probed by adaptive-optics-assisted direct imaging and sparse aperture masking, while close binaries can be resolved by photometry and spectroscopy. However, optical long baseline interferometry is mandatory to establish the multiplicity of Galactic massive stars at the separation gap between 1 and 50 mas.
Aims. In this paper, we aim to demonstrate the capability of the new interferometric instrument MIRC-X, located at the CHARA Array, to study the multiplicity of O-type stars and therefore probe the full range of separation for more than 120 massive stars (H < 7.5 mag).
Methods. We initiated a pilot survey of bright O-type stars (H < 6.5 mag) observable with MIRC-X. We observed 29 O-type stars, including two systems in average atmospheric conditions around a magnitude of H = 7.5 mag. We systematically reduced the obtained data with the public reduction pipeline of the instrument. We analyzed the reduced data using the dedicated python software CANDID to detect companions.
Results. Out of these 29 systems, we resolved 19 companions in 17 different systems with angular separations between ~0.5 and 50 mas. This results in a multiplicity fraction ƒm = 17/29 = 0.59 ± 0.09, and an average number of companions ƒc = 19/29 = 0.66 ± 0.13. Those results are in agreement with the results of the SMASH+ survey in the Southern Hemisphere. Thirteen of these companions have been resolved for the first time, including the companion responsible for the nonthermal emission in Cyg OB2-5 A and the confirmation of the candidate companion of HD 47129 suggested by SMASH+.
Conclusions. A large survey on more than 120 northern O-type stars (H < 7.5) is possible with MIRC-X and will be fruitful.
Analysing the SEDs of protoplanetary disks with machine learning
Authors: Kaeufer T. , Woitke P. , Min M. , Kamp I. , Pinte C. 
Published: February 2023

Context. The analysis of spectral energy distributions (SEDs) of protoplanetary disks to determine their physical properties is known to be highly degenerate. Hence, a full Bayesian analysis is required to obtain parameter uncertainties and degeneracies. The main challenge here is computational speed, as one proper full radiative transfer model requires at least a couple of CPU minutes to compute.
Aims. We performed a full Bayesian analysis for 30 well-known protoplanetary disks to determine their physical disk properties, including uncertainties and degeneracies. To circumvent the computational cost problem, we created neural networks (NNs) to emulate the SED generation process.
Methods. We created two sets of MCFOST Monte Carlo radiative transfer disk models to train and test two NNs that predict SEDs for continuous and discontinuous disks, with 18 and 26 free model parameters, respectively. A Bayesian analysis was then performed on 30 protoplanetary disks with SED data collected by the FP7-Space DIANA project to determine the posterior distributions of all parameters. We ran this analysis twice, (i) with old distances and additional parameter constraints as used in a previous study, to compare results, and (ii) with updated distances and free choice of parameters to obtain homogeneous and unbiased model parameters. We evaluated the uncertainties in the determination of physical disk parameters from SED analysis, and detected and quantified the strongest degeneracies.
Results. The NNs are able to predict SEDs within ~1 ms with uncertainties of about 5% compared to the true SEDs obtained by the radiative transfer code. We find parameter values and uncertainties that are significantly different from previous values obtained by χ2 fitting. Comparing the global evidence for continuous and discontinuous disks, we find that 26 out of 30 objects are better described by disks that have two distinct radial zones. The analysed sample shows a significant trend for massive disks to have small scale heights, which is consistent with lower midplane temperatures in massive disks. We find that the frequently used analytic relationship between disk dust mass and millimetre-flux systematically underestimates the dust mass for high-mass disks (dust mass ≥10−4 M⊙). We determine how well the dust mass can be determined with our method for different numbers of flux measurements. As a byproduct, we created an interactive graphical tool that instantly returns the SED predicted by our NNs for any parameter combination.
The SPIRou legacy survey
Authors: Fouqué P. , Martioli E. , Donati J.-F. , Lehmann L. T. , Zaire B. , Bellotti S. , Gaidos E. , Morin J. , Moutou C. , Petit P. , Alencar S. H. P. , Arnold L. , Artigau É. , Cang T.-Q. , Carmona A. , Cook N. J. , Cortés-Zuleta P. , Cristofari P. I. , Delfosse X. , Doyon R. , Hébrard G. , Malo L. , Reylé C. , Usher C. 
Published: February 2023

Context. The rotation period of stars is an important parameter together with mass, radius, and effective temperature. It is an essential parameter for any radial velocity monitoring, as stellar activity can mimic the presence of a planet at the stellar rotation period. Several methods exist to measure it, including long sequences of photometric measurements or temporal series of stellar activity indicators.
Aims. Here, we use the circular polarization in near-infrared spectral lines for a sample of 43 quiet M dwarfs and compare the measured rotation periods to those obtained with other methods.
Methods. From Stokes V spectropolarimetric sequences observed with SPIRou at the Canada-France-Hawaii Telescope and the data processed with the APERO pipeline, we computed the least-squares deconvolution profiles using different masks of atomic stellar lines with known Landé factor appropriate to the effective temperature of the star. We derived the longitudinal magnetic field to examine its possible variation in 50 to 200 observations of each star. To determine the stellar rotation period, we applied a Gaussian process regression, enabling us to determine the rotation period of stars with evolving longitudinal field.
Results. We were able to measure a rotation period for 27 of the 43 stars of our sample. The rotation period was previously unknown for 8 of these stars. Our rotation periods agree well with periods found in the literature based on photometry and activity indicators, and we confirm that near-infrared spectropolarimetry is an important tool for measuring rotation periods, even for magnetically quiet stars. Furthermore, we computed the ages for 20 stars of our sample using gyrochronology.
Der Einfluss von Industrie-Sponsoring auf Forschungsergebnisse
randomisierter klinischer Studien in der Plastischen und Ästhetischen
Chirurgie: Eine Querschnittsanalyse der letzten 12 Jahre
Authors: Alawi Seyed Arash , Grigorescu Oana , Bota Olimpiu , Dragu Adrian 
Published: February 2023

Zusammenfassung
Hintergrund Die Finanzierung von Forschungsprojekten im Fachbereich der
Plastischen, Rekonstruktiven und Ästhetischen Chirurgie wird zunehmend
durch Industrieunternehmen übernommen. Zielsetzung dieser Arbeit ist es,
randomisierte klinische Studien (RCTs) von führenden internationalen
Journalen für Plastische, Rekonstruktive und Ästhetische
Chirurgie zu untersuchen. Hierbei wurden die Kenndaten und die jeweils
zugrundeliegenden Studienergebnisse in Abhängigkeit zur Finanzierung
untersucht.
Material und Methoden Es erfolgte eine Auswertung der Kenndaten sowie der
Finanzierung von RCTs international führender plastisch-chirurgischer
Journale im Zeitraum Januar 2010 bis Januar 2022. Eine Kategorisierung wurde
zudem nach thematischen Schwerpunkten und den Ergebnissen im Hinblick auf
bestehende Finanzierungen durchgeführt.
Ergebnisse Insgesamt flossen die Daten von 381 RCTs in die Auswertung ein.
Von diesen waren 68,5% aus einer universitären Einrichtung
(n=261). Ein Großteil der Studien enthielt keine Angaben
über die zugrundeliegende Mittelherkunft. 26% der ausgewerteten
Forschungsstudien wurden durch Finanzmittel der Industrie gesponsort
(n=98) und in 9,7% durch die jeweilige
Universität/den Staat (n=37) (p<0,05,
95%-Konfidenzintervall). Der thematische Schwerpunkt der
durchgeführten Studien in privaten Praxen war Ästhetik
(n=32). Insgesamt wurden zum Thema der Ästhetik 28%
(n=153) der RCTs von der Industrie/private Träger vs.
9% Universität/Staat finanziert. Zum Thema
Rekonstruktion/Verbrennung/Handchirurgie wurden 9,2% der
Studien von der Industrie/privaten Trägern und 7,5% von
Universität/Staat finanziert. Die Finanzierung der Forschung
universitärer Einrichtungen wurde in 25% aus Mitteln der
Industrie beglichen (n=64). Von diesen industriegesponserten Studien
waren 73% (n=71) der Studienergebnisse konklusiv
produktfreundlich (p<0,05, 95%-Konfidenzintervall) und hatten
den thematischen Schwerpunkt der therapeutisch-medikamentösen
Anwendung/Produktanwendung (n=50, 75%).
Schlussfolgerung Bei der Finanzierung medizinischer Studien
übernehmen Industrie und private Träger sowohl im Bereich der
Rekonstruktion als auch der Ästhetik eine führende Rolle,
dennoch wird der größere Teil der Studien bisher nicht durch
diese finanziert. Erfolgte die Finanzierung jedoch durch Industrieunternehmen,
konnte signifikant ein positives Studienergebnis verzeichnet werden. Aktuell
wird der Themenbereich der Ästhetik durch die Industrie häufiger
finanziert als die Themenbereiche in der Rekonstruktion, Verbrennungs- und
Handchirurgie.
Differentielle Wirksamkeit einer internetbasierten
kognitiv-behavioralen Schreibtherapie zur Reduktion von PTBS-Symptomen nach
intensivmedizinischer Behandlung: Ergebnisse einer
Per-Protokoll-Analyse
Authors: Knaevelsrud Christine , Rosendahl Jenny , Reck Johannes , Gawlytta Romina , Kesselmeier Miriam , Böttche Maria , Niemeyer Helen 
Published: February 2023

Zusammenfassung
Ziel Es wurde die differentielle Wirksamkeit einer internetbasierten,
kognitiv-behavioralen Schreibtherapie (iCBT) zur Reduktion der Symptome einer
posttraumatischen Belastungsstörung (PTBS) bei intensivmedizinisch
behandelten Patient*innen und deren Partner*innen
untersucht.
Methodik Im Rahmen einer Reanalyse von Daten einer
randomisiert-kontrollierten Studie erfolgte der Vergleich der
PTBS-Symptomschwere (gemessen mittels PCL-5) vor und nach Therapie in der
Per-Protocol-Population in Abhängigkeit möglicher
Einflussfaktoren.
Ergebnisse Es zeigte sich eine signifikante Reduktion der
posttraumatischen Symptomschwere nach der Therapie. Elf von 25 behandelten
Teilnehmenden wiesen eine klinisch bedeutsame Veränderung (PCL-5
Differenz≥10 Punkte) auf. Die von den Teilnehmer*innen
geschriebene Wortzahl in den Therapiemodulen hatte einen signifikanten Einfluss
auf den Therapiererfolg.
Schlussfolgerung Die iCBT stellt eine vielversprechende Option zur
Erweiterung des Behandlungsspektrums bei PTBS, insbesondere für
körperlich eingeschränkte Patient*innen nach kritischer
Erkrankung dar.
Kompetenzprofil für Fachpersonen in der Suchthilfe und
Suchtprävention
Authors: Amberg Helen , Schumacher Jann 
Published: February 2023

ZusammenfassungIn der Schweiz verfügen die im Bereich Sucht tätigen Fachpersonen
über verschiedene Grundausbildungen, eine suchtspezifische
Grundausbildung gibt es nicht. Dennoch sollten Fachpersonen über
vielfältige spezifische Fähigkeiten verfügen, um in der
Suchtprävention oder Suchthilfe tätig zu sein. Aus diesem Grund
wurde ein sucht- und berufsgruppenübergreifendes Kompetenzprofil
entwickelt, welches grundlegende und weiterführende spezifische
Kompetenzen umfasst.