bluuebunny/crossref_metadata_2025_split huggingface dataset:
Warped product pointwise PR-semi-slant immersions in para-Kähler manifolds
Authors: Kumar A. , Sharma A. 
Published: January 2025

This study investigates the geometry of warped product pointwise PR-semi- slant immersions M in para-Kahler manifolds M̄2m that naturally englobes the warped product PR and semi-slant immersions. We first derive the non-existence of warped product Mλ ×f MT, and then by presenting a numerical example examine the presence of warped product M such that M = MT ×fMλ in M̄2m. Finally, we derive some characterizations for pointwise PR-semi-slant submanifolds to be locally warped product MT ×f Mλ in terms of shape operator and endomorphisms. The mixed totally geodesic case is also discussed.
The length of price&reimbursement negotiation procedures in Italy in the period 2021-2023 was independent from the price of medicines
Authors: Cocciolo Raffaella , Turella Paola , Pilunni Daniela , Navarra Pierluigi 
Published: January 2025

Background: The duration of price&reimbursement (P&R) procedures is taken as a key performance indicator of Regulatory Agencies in Europe. In this study we have tested the hypothesis that the price of medicines may have negatively affected the duration of P&R negotiations in Italy in the period 2021-2023.
Methods: Data were retrieved from the Intexo database, which included all medicines with EC approval within the period 2021-2023. Biosimilars, generics, gene therapies, Sars-Cov-2 vaccines and medicines with no negotiated price at the datalock of December 2023 were excluded from the analysis. The ex-factory price of the most expensive package was taken as the price of each reimbursed medicine, whereas the time between the publication of EC decision in the European GU and the publication of P&R AIFA decision in the Italian GU (gazette-to-gazette time) as well as the time between the submission of P&R dossier and the publication of AIFA decision in the Italian GU (AIFA negotiation time) were taken as the procedure duration.
Results: Sixty-seven EC approved medicines completed the P&R procedure in Italy within the study period, and had a reimbursed price. The median and mean gazette-to-gazette times were 395 and 442.6 days, respectively, whereas the mean and median AIFA negotiation times were 389.5 and 434.7 days, respectively. The mean price was 10,942 euros. The analysis of correlation between the duration of procedure and the negotiated price showed that there is no correlation whatsoever between the length of procedures and the price of medicines.
Conclusions: We can reasonably exclude that the price of medicines negatively affected the duration of P&R negotiation procedures.
Evaluation of machine learning techniques for real-time prediction of implanted lower limb mechanics
Authors: Maag Chase , Fitzpatrick Clare K. , Rullkoetter Paul J. 
Published: January 2025

IntroductionAccurate prediction of knee biomechanics during total knee replacement (TKR) surgery is crucial for optimal outcomes. This study investigates the application of machine learning (ML) techniques for real-time prediction of knee joint mechanics.MethodsA validated finite element (FE) model of the lower limb was used to generate a dataset of knee joint kinematics, kinetics, and contact mechanics. The models were trained on joint alignment data, ligament information, and external boundary conditions. Several predictive algorithms were explored, including linear regression (LRM), multilayer perceptron (MLP), bi-directional long short-term memory (biLSTM), convolutional neural network (CNN), and transformer-based approaches. The performance of these models was evaluated using average normalized root mean squared error (nRMSE).ResultsThe biLSTM model achieved the highest accuracy, with a significantly lower nRMSE compared to other models. Compared to traditional FE or rigid body dynamics models, these predictive models offered significantly faster prediction speeds, enabling near-instantaneous insights into the TKR system’s performance. The small size of the predictive models makes them suitable for deployment on edge devices potentially used in operating rooms.DiscussionThese findings suggest that real-time biomechanical prediction using biLSTM models has the potential to provide valuable feedback for surgeons during TKR surgery. Applications of this work could be applied to provide pre-operative guidance on optimal target implant alignment or given the real-time prediction ability of these models, could also be used intra-operatively after integration of patient-specific intra-op kinematic and soft-tissue information.
Upconverter loaded MoS2 counter electrode for broadband dye-sensitized solar cell applications
Authors: Kawya J. , Durairaj M. , Anandan S. , Sabari Girisun T. C. 
Published: January 2025

An interesting approach of including an upconverter in the MoS2 counter electrode can yield broadband light harvesting Pt-free DSSC assembly. Here different upconverter (UC) nanoparticles (Yb, Er incorporated NaYF4, YF3, CeO2 &amp; Y2O3) were synthesized and loaded in MoS2 thin film by hydrothermal method. The inclusion of UCs in MoS2 films exposed without any secondary formation of upconverters and the uniform deposition of the films are confirmed through XRD and FESEM analysis respectively. The absorption spectrum (UV-Vis-NIR) confirms the increase in absorption intensity in visible and NIR regions due to the incorporation of UCs. Under 980 nm excitation, the UCs-loaded MoS2 films show emission in blue (450–490 nm), green (520–540 nm) and red (600–700 nm) regions due to the f-f inner transition occurring in the Er ions. The oxide and fluoride UCs-based DSSCs were fabricated with an FTO/TiO2/N719/Triiodide electrolyte/UC@MoS2/FTO assembly. Oxide UCs show greater electrocatalytic activity, which might be owed to the films exposed with more catalytic active sites favourable for ion transportation in the I−/I−3 electrolyte. Among them, higher photoconversion efficiency (PCE) of 7.1% was witnessed for (Y2O3: Er, Yb) @MoS2 counter electrode-based DSSC which is due to the good conductivity (RS) of the film, the longer electron lifetime and photon harvesting enhancement by upconversion process. It is notably convinced that the UC-loaded MoS2 films can be used as an effective counter electrode for the possible realization of upconverter DSSC and used for broadband light absorption.
Efficacy and safety of cardiac myosin inhibitors for symptomatic hypertrophic cardiomyopathy: a meta-analysis of randomized controlled trials
Authors: Abunada Anas , Shah Madiha , Kumar Ateesh , Lamiya Mir Syeda , Kumar Dinesh , Ahmed Saboor , Tanzeel Muhammad , Kumar Vikash , Meghjiani Aashish , Siddiqui Muhammad Basit Ali , Khatri Govinda , Rai Aneesh , Deepak Fnu , Kumar Ayush 
Published: January 2025

IntroductionHypertrophic cardiomyopathy (HCM) is a common genetic heart disorder. It is characterized by left ventricular hypertrophy and impaired cardiac function, with forms categorized into obstructive (oHCM) and nonobstructive (nHCM). Traditional treatments address symptoms but not the underlying disease mechanism, highlighting the need for novel therapies. Cardiac myosin inhibitors such as mavacamten and aficamten present potential new treatment options.MethodsA meta-analysis of randomized controlled trials (RCTs) was conducted following PRISMA guidelines. Studies comparing cardiac myosin inhibitors with placebo were reviewed, and outcomes related to NYHA functional class, Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS), LVOT gradients, and left ventricular ejection fraction (LVEF) were analyzed.ResultsSix RCTs involving 826 participants demonstrated that mavacamten and aficamten significantly improved NYHA functional class and KCCQ-CSS scores. The incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) was similar between the treatment and control groups, indicating a comparable safety profile.ConclusionCardiac myosin inhibitors are effective in improving cardiac function and reducing LVOT obstruction in HCM patients. They offer a promising alternative to current treatments, with a safety profile comparable to placebo. Further research is needed to confirm long-term benefits.
Risk prediction models for depression in patients with coronary heart disease: a systematic review and meta-analysis
Authors: Zhang Jie , Zhou Yue , Huang Linyu , Zhang Xingling , Li Long , Xi Chongcheng 
Published: January 2025

BackgroundRisk prediction models for depression in patients with coronary heart disease are increasingly being developed. However, the quality and applicability of these models in clinical practice remain uncertain.ObjectiveTo systematically evaluate depression risk prediction models in patients with coronary heart disease (CHD).MethodsDatabases including PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang, VIP, and SinoMed were searched for relevant studies from inception to September 29, 2024. Two researchers independently screened the literature, extracted data, and used the Prediction Model Risk of Bias Assessment Tool (PROBAST) to evaluate the models' risk of bias and applicability.ResultsEight studies, encompassing 13 risk prediction models and involving 8,035 CHD patients, were included, with 1,971 patients diagnosed with depression. Common predictors included age, educational level, gender, and cardiac function classification. The area under the curve (AUC) for the models ranged from 0.772 to 0.961, indicating overall good performance; however, risk of bias was high, primarily due to issues in the analysis phase, such as inadequate handling of missing values, univariate analysis for variable selection, and lack of external validation.ConclusionDepression risk prediction models for CHD patients generally perform well, but high risk of bias and limited applicability remain concerns. Future studies should focus on developing and validating more robust models to aid healthcare professionals in early identification of high-risk patients for depression.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024625641, identifier (CRD42024625641).
A critical approach to SDGs through Collaborative Online International Learning: experiences from Canada and Spain
Authors: Campoy-Cubillo Mari Carmen , Jimenez-Estrada Vivian 
Published: January 2025

IntroductionThe Collaborative Online International Learning (COIL) is described as a pedagogical experience linking the classrooms of two or more higher education institutions across culturally and linguistically differentiated regions. COIL intends to provide academics and students with the ability to communicate and collaborate with peers internationally through online interactions. During the Fall of 2021, this collaboration involved the Universitat Jaume I (UJI), located in the city of Castelló de la Plana in Spain and Algoma University, located on the traditional territory of the Anishinaabek Nation, as well as the homelands of the Métis Nation. The student profiles, each institutions’ geographical locations, as well as the linguistic, cultural and critical approaches to teaching and learning provided ample opportunities and challenges for the development and implementation of this experience.MethodsThe purpose of this paper is to provide a pedagogical reflection on the development of a 5-week module taught together during three academic years. The authors provide an account and reflection of their collaboration centered on the institutional challenges and opportunities that currently exist for courses that aim to engage Indigenous and critical/ecological thinking.Results and discussionThe background of the collaboration leads to a detailed analysis of the context of COIL implementation and the reflections on the modules’ development and improvement. Our recommendations are based on lessons learned from the substantive and technical challenges and opportunities on the complexity of teaching about contemporary ecological/social issues, as well as the tools required to inspire future activists.
DAMPs prognostic signature predicts tumor immunotherapy, and identifies immunosuppressive mechanism of pannexin 1 channels in pancreatic ductal adenocarcinoma
Authors: Wu Qianxue , Xiao Qian , Tang Xin , Li Liuying , Song Daqiang , Zhou Yang , Li Benhua , Ren Guosheng , Luo Fang 
Published: January 2025

BackgroundDamage-associated molecular patterns (DAMPs) induced by immunogenic cell death (ICD) may be useful for the immunotherapy to patients undergoing pancreatic ductal adenocarcinoma (PDAC). The aim of this study is to predict the prognosis and immunotherapy responsiveness of PDAC patients using DAMPs-related genes.MethodsK-means analysis was used to identify the DAMPs-related subtypes of 175 PDAC cases. The significance of gene mutation and immune status in different subtypes was detected. LASSO regression was used to construct a DAMPs-related prognostic signature to predict the immunotherapy responsiveness of PDAC. Subsequently, in vivo and in vitro experiments and Bulk-RNA seq were used to verify the effect of hub gene pannexin 1 (PANX1) on PDAC.ResultsTwo subtypes were clustered based on the expression levels of DAMPs genes from 175 PDAC patients. Besides, the prognosis and immune landscape in up-regulated DAMPs expression subtypes was poor. In addition, we constructed a DAMPs-related prognostic signature that correlated with immune cell infiltration and predicted immunotherapy or chemotherapy responsiveness of patients with PDAC. Mechanically, through Bulk-RNA sequencing and experiments, we found that PANX1 promoted tumor progression and immune regulation via the ATP release to active NOD1/NFκB signaling pathway in PDAC.ConclusionOur in silico analyses established a classification system based on ICD-related DAMPs genes in PDAC, and constructed a DAMPs-related prognostic model to predict the efficacy of immunotherapy. This study will provide a new perspective for targeting the DAMPs-related molecule PANX1 in the treatment of PDAC.
Clinical features and prognostic factors of pediatric Langerhans cell histiocytosis: a single-center retrospective study
Authors: Lu Yunfeng , Liu Liying , Wang Qi , Liu Bingju , Zhao Ping , Guan Guotao , Dai Yunpeng 
Published: January 2025

PurposeTo retrospectively evaluate the clinical features and prognostic factors of pediatric LCH patients treated in a single center of China.MethodsPediatric LCH cases were treated following the SD-LCH protocol at the Affiliated Provincial Hospital of Shandong First Medical University in Jinan, China. An analysis was conducted on 82 recently identified LCH cases to retrospectively evaluate the initial symptoms, therapeutic alternatives, and extended results. Follow-ups were conducted until July 31, 2023.ResultsThe median age at diagnosis was 2 (0.25–12) years. 42 (51.2%) were SS-LCH, and 40 (48.8%) were MS-LCH. The most common organ involved was bone (82.9%). Over the 16-year follow-up period, the 5-year EFS and OS rates were 75.2 ± 5% and 90.9 ± 3.3%, respectively. The cumulative reactivation rate was 23.2%. The 5-year EFS rate in SS-LCH and MS-LCH patients were 90.2 ± 4.6% and 58.8 ± 8.3%, and the 5-year OS rate in SS-LCH and MS-LCH patients were 90.2 ± 4.6% and 81.2 ± 6.5%, respectively. The 5-year OS and EFS rate in RO+ LCH and RO− LCH patients were 79.5 ± 7.5%, 53.8 ± 9.6% and 87.5 ± 11.7%, 76.2 ± 14.8%, insignificantly. Multivariate Cox regression showed that liver involvement predicted poor EFS and hematological system involvement was an independent prognostic factor for OS. Detection of the BRAFV600E mutation and targeted therapy significantly improved the prognosis post-2017.ConclusionLiver or hematological system involvement indicates a poor prognosis, and the SD-LCH protocol improves prognosis for pediatric LCH patients.
The mediating effect of clinical belongingness on the relationship between anxiety and professional identity in nursing interns: a cross-sectional study
Authors: Zhang Junhao , Wang Lijia , Yang Xue , Yang Yuwei , Wu Xuehua , Huang Huaping , Li Guirong 
Published: January 2025

BackgroundPrevious studies have reported that anxiety negatively affects professional identity (PI), and clinical belongingness is positively correlated with PI among nursing interns. However, little is known about the relationship between anxiety, PI, and clinical belongingness among nursing interns.ObjectiveTo explore the relationship between PI, clinical belongingness, and anxiety among nursing interns, and to demonstrate the mediating role of clinical belongingness in this relationship.MethodsA cross-sectional study using an online questionnaire was conducted between November 2023 and January 2024 among 1,050 nursing interns from 26 teaching hospitals in Sichuan Province, China. A general information questionnaire, the Belongingness Scale-Clinical Placement Experience (BES-CPE), the Self-Rated Anxiety Scale (SAS), and the Professional Identity Questionnaire for Nursing Students (PIQNS) were used to collect data. SPSS (version 25.0) and AMOS (version 28.0) were used to analyze the data.ResultsNursing interns had moderate mean scores for all variables; PI (60.77 ± 12.18), clinical belongingness (115.99 ± 17.02), and anxiety (47.44 ± 8.75). Correlation analyses revealed that both PI (r = −0.129, p &lt; 0.01) and clinical belongingness (r = −0.087, p &lt; 0.01) were negatively correlated with anxiety and clinical belongingness was positively correlated with PI (r = 0.601, p &lt; 0.01). The clinical belongingness of nursing interns had a mediating effect on the relationship between anxiety and PI (β = −0.072, 95% confidence interval = −0.133 to −0.013, p &lt; 0.001), accounting for 40% of the total effect.ConclusionThe anxiety level of nursing interns can have a direct impact on the prediction of PI and an indirect influence on PI mediated by clinical belongingness. Accordingly, nursing educators and managers should screen and channel the mental health problems of nursing interns in a timely manner, improving their clinical belonging, which will help improve PI and ultimately improve the stability of the nursing workforce.
Psychological abuse and its influencing factors among home-dwelling older people in Northern China: a cross-sectional survey
Authors: Wu Xiaomeng , Pei Li , Wang Yu , Zhang Lanrui , Zhao Dongqing , Dou Haoying 
Published: January 2025

BackgroundAs the population ages, the subject of elder abuse has become more prominent, with psychological abuse of older people being particularly prevalent. This leads to a higher incidence of anxiety, depression, and other psychological problems among older people, reducing their quality of life, and even jeopardizing their safety.MethodsA cross-sectional questionnaire survey was conducted to investigate psychological abuse among home-dwelling older people in Northern China and its influencing factors. Participants were surveyed using a demographic questionnaire, activities of daily living (ADL), family adaptability and cohesion evaluation scale (FACES), and elder psychological abuse scale. The factors impacting psychological abuse were examined using binary logistic regression.ResultsA total of 465 home-dwelling older people participated in the study, with an effective response rate of 97.89%. The median item score of psychological abuse was 20 (IQR: 18–22), activities of daily living was 15 (IQR: 14–17), and family adaptability and cohesion was 96 (IQR: 86–105). Binary logistic regression analysis indicated that the factors affecting psychological abuse among home-dwelling older people were residence in rural areas (OR = 3.487, 95% CI = 2.121–5.732), monthly income ≥ 3,501 (OR = 0.342, 95% CI = 0.119–0.987), had chronic diseases (OR = 2.202, 95% CI = 1.356–3.576), and FACES (OR = 0.955, 95% CI = 0.936–0.974) were the factors that influenced the prevalence of psychological abuse.ConclusionIn Northern China, the level of psychological abuse among older people is low. It is associated with residence, monthly income, chronic diseases, and family adaptability and cohesion. Further studies are required to understand the underlying causes and develop effective interventions to reduce psychological abuse and ensure a comfortable old life for older Chinese people.
Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021
Authors: Guo Jingxun , Liu Zhen , Wang Pengjun , Wu Heming , Fan Kai , Jin Jianbo , Zheng Lan , Liu Zeyu , Xie Renyi , Li Cheng 
Published: January 2025

BackgroundChronic kidney disease (CKD) is a significant global health issue, often linked to diabetes, hypertension, and glomerulonephritis. However, aggregated statistics can obscure heterogeneity across subtypes, age, gender, and regions. This study aimed to analyze global CKD trends from 1990 to 2021, focusing on age, gender, socio-demographic index (SDI), and regional variations.MethodsData were extracted from the Global Burden of Disease (GBD) 2021 database, covering prevalence, incidence, mortality, and disability-adjusted life years (DALYs). These were presented as counts per 100,000 population and age-standardized rates, with uncertainty intervals (UIs) to highlight variability. Joinpoint regression was used to assess trends over the 30-year period.ResultsIn 2021, global CKD prevalence was 359 million, with 11.13 million new cases, 1.53 million deaths, and 44.45 million DALYs—up 92, 156, 176, and 114% since 1990. While prevalence slightly declined, incidence, mortality, and DALYs increased significantly. CKD burden varied by region and age, with notable gender disparities.ConclusionThe study highlights a dramatic rise in CKD burden linked to population growth and aging, emphasizing the need for targeted treatment and effective global healthcare policies.
Development of digital therapeutics in Hwa-byung treatment: exploring innovation potential in Korean medicine through practitioner survey
Authors: Kwon Chan-Young 
Published: January 2025

IntroductionHwa-byung (HB) is a culture-bound anger syndrome prevalent in Korea. While clinical practice guidelines emphasize mind–body modalities (MBMs) and psychotherapies for HB treatment, their implementation in Korean medicine (KM) remains unexplored. Digital therapeutics (DTx) offers potential solutions for treatment delivery barriers. This study investigated current HB treatment practices among KM doctors and their perceptions on DTx implementation.MethodsA nationwide web-based survey of licensed KMDs (N = 864) was conducted in South Korea (August–September 2024). The survey assessed HB treatment practices, utilization of MBMs and psychotherapies, and attitudes toward DTx. Data were analyzed using descriptive statistics.ResultsMost KMDs utilized conventional KM treatments (acupuncture 95.4%, herbal medicine 94.0%), while MBMs (26.2%) and psychotherapies (21.3%) were underutilized despite their recognized importance. Primary barriers included time constraints (65.8%) and insufficient knowledge (62.9%). Treatment typically required 15.6 ± 60.7 weeks with 21.6 ± 37.4 sessions. While DTx knowledge was limited (mean score 2.3 ± 0.9/5), most KMDs (70.6%) expressed interest in DTx development, with 65.4% willing to implement it in practice. The estimated appropriate cost for HB DTx was 24,441.5 ± 13,566.0 KRW per session.ConclusionThis study reveals a significant gap between guidelines and clinical practice in HB treatment, particularly in implementing MBMs and psychotherapies. The positive attitude toward DTx suggests its potential as a practical solution to bridge this gap by providing accessible, standardized delivery of evidence-based psychological interventions within existing clinical workflows. Future DTx development should focus on addressing identified barriers while maintaining alignment with KM principles.