bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parametric analysis of pitch angle scattering and losses of relativistic electrons by oblique EMIC waves
Authors: Hanzelka Miroslav , Li Wen , Ma Qianli 
Published: April 2023

This study analyzes the effects of electromagnetic ion cyclotron (EMIC) waves on relativistic electron scattering and losses in the Earth’s outer radiation belt. EMIC emissions are commonly observed in the inner magnetosphere and are known to reach high amplitudes, causing significant pitch angle changes in primarily >1 MeV electrons via cyclotron resonance interactions. We run test-particle simulations of electrons streaming through helium band waves with different amplitudes and wave normal angles and assess the sensitivity of advective and diffusive scattering behaviors to these two parameters, including the possibility of very oblique propagation. The numerical analysis confirms the importance of harmonic resonances for oblique waves, and the very oblique waves are observed to efficiently scatter both co-streaming and counter-streaming electrons. However, strong finite Larmor radius effects limit the scattering efficiency at high pitch angles. Recently discussed force-bunching effects and associated strong positive advection at low pitch angles are, surprisingly, shown to cause no decrease in the phase space density of precipitating electrons, and it is demonstrated that the transport of electrons into the loss cone balances out the scattering out of the loss cone. In the case of high-amplitude obliquely propagating waves, weak but non-negligible losses are detected well below the minimum resonance energy, and we identify them as the result of non-linear fractional resonances. Simulations and theoretical analysis suggest that these resonances might contribute to subrelativistic electron precipitation but are likely to be overshadowed by non-resonant effects.
Establishment of a Sonotrode Extraction Method and Evaluation of the Antioxidant, Antimicrobial and Anticancer Potential of an Optimized Vaccinium myrtillus L. Leaves Extract as Functional Ingredient
Authors: Gil-Martínez Lidia , Aznar-Ramos María José , del Carmen Razola-Diaz Maria , Mut-Salud Nuria , Falcón-Piñeiro Ana , Baños Alberto , Guillamón Enrique , Gómez-Caravaca Ana María , Verardo Vito 
Published: April 2023

Vaccinium myrtillus L. (bilberry) leaves are an important by-product of berry production that may be used as a source of phenolic compounds which have a positive effect on human health. Therefore, an ultrasound-assisted extraction via sonotrode has been used for the first time to recover bioactive compounds from bilberry leaves. The extraction has been optimized using a Box–Behnken design. The influence of ethanol:water ratio (v/v), time of extraction (min) and amplitude (%) were evaluated considering total phenolic content (TPC) and antioxidant capacity (DPPH and FRAP assays) as dependent variables in a response surface methodology (RSM). Optimum values for the independent factors were 30:70 ethanol/water (v/v), 5 min of extraction and 55% amplitude. The empirical values of the independent variables using the optimized conditions were 217.03 ± 4.92 mg GAE/g d.w. (TPC), 271.13 ± 5.84 mg TE/g d.w. (DPPH) and 312.21 ± 9.30 mg TE/g d.w. (FRAP). The validity of the experimental design was confirmed using ANOVA and the optimal extract was characterized using HPLC-MS. A total of 53 compounds were tentatively identified, of which 22 were found in bilberry leaves for the first time. Among them, chlorogenic acid was the most abundant molecule, representing 53% of the total phenolic compounds identified. Additionally, the antimicrobial and anticancer activities of the optimum extract were tested. Gram-positive bacteria demonstrated high sensitivity to bilberry leaves extract in vitro, with MBC values of 6.25 mg/mL for Listeria monocytogenes, Listeria innocua and Enterococcus faecalis, and 0.8 mg/mL for Staphylococcus aureus and Bacillus cereus. Furthermore, bilberry leaves extract exerted in vitro antiproliferative activity against HT-29, T-84 and SW-837 colon tumor cells with IC50 values of 213.2 ± 2.5, 1140.3 ± 5.2 and 936.5 ± 4.6 μg/mL, respectively. Thus, this rapid ultrasound-assisted extraction method has demonstrated to be an efficient technique to obtain bilberry leaves extract with in vitro antioxidant, antimicrobial and anticancer capacities that may be useful for the food industry as natural preservative or even for the production of functional foods or nutraceuticals.
Papilledema: A Problem of Modern Ophthalmology, Neurology, and Neurosurgery
Authors: Крамаренко А.Н. , Марьенко И.П. 
Published: April 2023

Застойный диск зрительного нерва (ЗДЗН) – отек диска зрительного нерва, вызванный повышенным внутричерепным давлением и обычно носящий билатеральный характер. В работе представлен обзор актуальных данных по патогенезу, эпидемиологии, классификации, дифференциальной диагностике, особенностям протекания ЗДЗН и прогнозам для зрения в исходе заболевания. Дифференциальная диагностика ЗДЗН и других изменений диска зрительного нерва (ДЗН), схожих по офтальмоскопической картине, по-прежнему представляет серьезную трудность. Имеющиеся методы диагностики при их изолированном использовании не всегда могут помочь дифференцировать отек и псевдоотек ДЗН. Решение этой задачи часто требует мультимодального офтальмологического обследования и междисциплинарного подхода. Наблюдается существенный недостаток данных о специфичных признаках, характерных для истинного ЗДЗН. Изучение корреляции состояния зрительного нерва с уровнем внутричерепного давления может помочь в разработке критериев неинвазивной диагностики повышенного внутричерепного давления.
Papilledema is optic disk swelling, caused by increased intracranial pressure and usually having a bilateral pattern. We present a review of current data on pathogenesis, epidemiology, classification, differential diagnosis, edema evolution and visual outcome prognosis. Differential diagnosis of the papilledema and other similar optic disc changes is still difficult. The available diagnostic methods, when used isolated, not always can help in differentiating between papilledema and pseudopapilledema. The solution often requires a multimodal ophthalmological examination and an interdisciplinary approach. There is a significant lack of data on the specific diagnostic features for true papilledema. Thorough studying of the correlation between the optic nerve status and the intracranial pressure level may help in elaborating criteria for non-invasive diagnosis of increased intracranial pressure.
Pediatric Skull Base Fractures. Part 3: Surgical Treatment
Authors: Миронец Е.В. , Талабаев М.В. , Журавлев В.А. 
Published: April 2023

В статье приводится обзор отечественной и зарубежной литературы, описывающий современные подходы к хирургическому лечению переломов основания черепа (ПОЧ) и их осложнений. Уделяется внимание показаниям к оперативному лечению и срокам его выполнения. Подняты вопросы эндоскопического и транскраниального способов лечения ликвореи при ПОЧ, приводятся основные преимущества и недостатки данных методик в зависимости от локализации и размеров ликворной фистулы. Изложены основные принципы оперативного лечения, виды хирургических подходов (открытый, эндоскопический) и материалов для пластики основания черепа с акцентом на пациентов детского возраста.
The article provides a review of domestic and foreign literature describing current approaches to surgical treatment of skull base fractures and their complications. Attention is paid to indications for surgical treatment and its terms. Issues of endoscopic and transcranial methods of cerebrospinal fluid leak treatment are raise, and the main advantages and disadvantages of these techniques depending on liquor fistula localization and size are presented. The main principles of surgical treatment, types of surgical approaches (open, endoscopic) and materials for skull base plasty with an emphasis on pediatric patients are outlined.
COVID-19 Associated Serous Meningitis and Optic Neuritis: A Case Report
Authors: Чечик Н.М. , Лихачев С.А. , Каплич Л.Л. , Качанко Е.Ф. , Апанович М.А. , Буняк А.Г. , Жучок А.Н. 
Published: April 2023

В настоящее время описаны различные варианты поражений нервной системы, ассоциированные с коронавирусной инфекцией COVID-19. Особое внимание уделяется таким остро развивающимся заболеваниям, как менингоэнцефалиты, инсульты, судорожные припадки, моно- и полиневропатии, энцефалопатии. Несмотря на имеющееся на текущий момент большое количество публикаций, данная проблема требует дальнейшего тщательного изучения, что связано с необходимостью систематизации данных, выявления новых патогенетических механизмов и разработки оптимальных терапевтических подходов. Огромный интерес также вызывает возможность возникновения у 1 пациента нескольких вариантов острого поражения структур центральной и периферической нервной системы. В статье представлено описание собственного клинического наблюдения пациента, у которого развились серозный менингит и оптический неврит, ассоциированные с коронавирусной инфекцией COVID-19. На примере клинического наблюдения рассмотрены особенности течения заболевания, подходы к диагностике и лечению, а также возможные сложности в процессе дифференциально-диагностического поиска.
Nowadays, a variety of nervous system lesions associated with COVID-19 infection has been described. A special attention is paid to such acute developing diseases as meningoencephalitis, strokes, seizures, mono- and polyneuropathy, and encephalopathy. Despite the large number of available publications, this issue requires further careful study due to the necessity of systematizing data, identifying new pathogenetic mechanisms, and developing optimal therapeutic approaches. The possibility of several variants of acute damage to the structures of the central and peripheral nervous system in the same patient is also of great interest. The article describes the own clinical observation of a patient who developed serous meningitis and optic neuritis associated with COVID-19 infection. The clinical features of the disease course and approaches to diagnosis, as well as possible difficulties in the differential diagnostic process are considered.
The non-unitary nature of information preference
Authors: Liew Shi Xian , Embrey Jake R. , Newell Ben R. 
Published: April 2023

AbstractFactors affecting information-seeking behaviour can be task-endogenous (e.g., probability of winning a gamble), or task-exogenous (e.g., personality trait measures). Various task-endogenous factors affecting non-instrumental information-seeking behaviour have been identified, but it is unclear how task-exogenous factors affect such behaviour, and if they interact with task-endogenous factors. In an online information seeking experiment (N = 279), we focus on the role that outcome probability, as a task-endogenous factor, has on information preferences. We find reliable preference for advance information on highly probable gains and low preference for highly probable losses. Comparisons with individual trait measures of information preference (e.g., intolerance of uncertainty scale, obsessive-compulsive inventory, information preferences scale) reveal minimal association between these task-exogenous factors with choice task performance. We also find minimal interaction between outcome probability and individual trait measures. Despite the choice task and trait measures purportedly tapping the same (or similar) construct, the absence of clear relationships ultimately suggests a multi-dimensional nature of information preference.
Pengaruh Kepemimpinan, Lingkungan Kerja, Komunikasi dan Budaya Organisasi terhadap Kepuasan Kerja (Suatu Kajian Studi Literatur Manajemen Sumber Daya Manusia)
Authors: Ahmadi Umar Rikco , EHJ FoEh John , A. Manafe Henny , Sia Niha Simon 
Published: April 2023

Abstract: This study will analyze leadership, work environment, and communication in influencing job satisfaction. The formulation of the problems in this study are: 1) Does leadership have a positive and important influence on employee job satisfaction?; 2) Does the work environment have a positive and important impact on worker job satisfaction?; 3) Does communication have a positive and important impact on employee job satisfaction?; 4) Does communication have a positive and important impact on employee job satisfaction; 5) Does leadership, work environment, communication, and organizational culture have a positive and important influence on employee job satisfaction?
Abstrak: Pada kajian ini akan menganalisis kepemimpinan, lingkungan kerja maupun komunikasi dalam memengaruhi kepuasan kerja. Rumusan masalah pada kajian ini, yakni: 1) Apakah kepemimpinan memberi pengaruh positif dan penting kepada kepuasan kerja karyawan?; 2) Apakah lingkungan kerja memberi akibat positif dan penting kepada kepuasan kerja pekerja?; 3) Apakah komunikasi memberi akibat positif dan penting kepada kepuasan kerja pekerja?; 4) Apakah komunikasi memberi akibat positif dan penting kepada kepuasan kerja pekerja; 5) Apakah kepemimpinan, lingkungan kerja, komunikasi dan budaya organisasi memberi pengaruh positif dan penting kepada kepuasan kerja karyawan.
Penguatan Manajemen Pengelolaan Pesantren Ainul Yaqin Kota Jambi
Authors: Rusmini Rusmini , Samsu Samsu , Dwi Nugroho Aris , Oryza Diandara , Hartoyo Zainal , Yulia Sari Sri , Miliani Masyrisal 
Published: April 2023

Pesantren merupakan salah satu Lembaga yang memiliki peranan penting dalam mencapai tujuan Pendidikan. Di Provinsi Jambi terdapat lebih kurang 214 lembaga Pesantren. Pesantren ini terus berkembang, ada yang konvensional dan modern. Salah satu Pesantren Modern di Kota Jambi adalah Pesantren Ainul Yaqin. Pesantren Ainul Yaqin berdiri semenjak tahun 2001, namun kurang berkembang dan cenderung stagnan padahal berada di pusat kota. Berdasarkan observasi, masalah utamanya adalah masalah manajemen, sehingga diperlukan pendampingan. Tujuan dari pendampingan adalah untuk meningkatkan kualitas pengelolaan Pesantren Ainul Yaqin Kota Jambi melalui pendampingan penguatan manajemen. Pendampingan dilakukan dengan menggunakan metode Participatory Action Research (PAR) dengan tahapan (a)Menyiapkan Community Action Plan (CAP) (b) Situation Analysis, (c)Doing with The Community, (d)The Inner Resources Approach, (e)Check (Evaluating and Controlling). Target pendampingan adalah komunitas Pesantren Ainul Yaqin Kota Jambi. Komunitas dipilih Setelah dilakukan studi pendahuluan dan wawancara. Penguatan manajemen pengelolaan berfokus pada manajemen pengelolaan Lembaga, manajemen personalia, manajemen kesiswaan, dan manajemen perpustakaan.
Modernité, tyrannie et crise
Authors: Marchal Kai , Quelennec Bruno 
Published: April 2023

Cet article se demande si un dialogue entre la civilisation chinoise et Leo Strauss est possible et à quelles conditions. Il décrit le contexte d’introduction de Strauss en Chine, en se concentrant sur Liu Xiaofeng, l’un des straussiens les plus influents de la Chine contemporaine. L’analyse de son interprétation de la critique straussienne de la modernité occidentale fait ressortir deux distorsions fondamentales : là où Strauss considérait l’« enseignement tyrannique » comme quelque chose de théorique, Liu en fait un plan d’action politique ; au lieu de reconnaître la modernité des bases idéologiques de l’État fondé par Mao Zedong, il les interprète au crible de la tradition. Cette double déformation contredit l’intention de Strauss en tant que philosophe zététique et socratique.
Géoarchéologie portuaire de la cité de Cumes (Campanie, Italie)
Authors: Morhange Christophe , Stefaniuk Lise 
Published: April 2023

La reconstitution paléo-environnementale obtenue de l’étude bio-sédimentologique des carottages permet d’affirmer que Cumes (région napolitaine, Italie) possédait, grâce à la présence de la lagune de Licola au nord de la cité, un abri côtier susceptible d’être utilisé comme port protégé dès l’époque archaïque. Néanmoins ce dernier devait être difficile d’accès via un grau. La présence de barres d’avant côtes à fleur d’eau rendait l’accès au chenal relativement périlleux. De plus, la migration au cours des siècles de ce dernier a dû également poser un problème délicat d’accessibilité pour les navires. Il faut aussi signaler les problèmes de colmatage accélérée de la lagune et les fluctuations du plan d’eau qui ont dû entraîner une adaptation régulière des structures portuaires et des relocalisations des installations. Les dynamiques géomorphologiques de la région de Cumes expliquent la rapide suprématie des ports proches mais moins contraignants comme Pouzzoles ou Misène aux dépens du médiocre abri côtier de Cumes-Licola. L’importance du bassin lagunaire de Cumes-Licola ne fit donc que décroître au fil des siècles jusqu’à disparaître, entièrement colmaté. À l’époque moderne seules de petites barques de pèche pouvaient encore circuler.
DESDOBRAMENTOS DA SÍNDROME PRÉ-MENSTRUAL SOBRE A SAÚDE MENTAL E O SONO : UMA REVISÃO SISTEMÁTICA
Authors: Laguila Altoé Isadora , Trannin de Mello Sônia , Francisquini Gardin Pamella 
Published: April 2023

Objetivo: Analisar, mediante revisão sistemática, se aspectos como privação de sono, estresse e ansiedade estão relacionados com a síndrome pré-menstrual.
Metodologia: Trata-se de uma Revisão Sistemática que investigou nas bases de dados Biblioteca Virtual em Saúde (BVS). Foram utilizados os Descritores em Ciências da Saúde “SPM”, “privação de sono”, “ansiedade”, "estresse" e "ciclo menstrual”, que foram associados ao operador booleano “AND”.
Resultados: As buscas resultaram em 369 artigos, dos quais 21 foram utilizados para a composição do estudo.
Discussão: Ficou evidente que a privação de sono, estresse e ansiedade possuem relação com a SPM. Além disso, encontrou-se estudos ressaltando que aspectos cotidianos (trabalho e estudos), condições nutricionais e outros transtornos neurológicos (como depressão e compulsão alimentar) afetam e podem ser afetados pelos sintomas da síndrome pré-menstrual. Tratamentos promissores para a sintomatologia da SPM também foram foco de vários artigos encontrados, os quais utilizaram diferentes terapêuticas.
Conclusão: A síndrome pré-menstrual associa-se a diversos fatores, porém essa temática possui inúmeras controvérsias e interesses científicos divergentes o que impacta a quantidade e a qualidade de estudos disponíveis sobre o ciclo reprodutivo feminino e seus desdobramentos.
The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1
Authors: Bélanger Simon , Haupt Sonya , Faliti Caterina E , Getzler Adam , Choi Jinyong , Diao Huitian , Karunadharma Pabalu P , Bild Nicholas A , Pipkin Matthew E , Crotty Shane 
Published: April 2023

Abstract
T follicular helper (TFH) cells are essential for developing protective Ab responses following vaccination. Greater understanding of the genetic program leading to TFH differentiation is needed. Chromatin modifications are central in the control of gene expression. However, detailed knowledge of how chromatin regulators (CRs) regulate differentiation of TFH cells is limited. We screened a large short hairpin RNA library targeting all known CRs in mice and identified the histone methyltransferase mixed lineage leukemia 1 (Mll1) as a positive regulator of TFH differentiation. Loss of Mll1 expression reduced formation of TFH cells following acute viral infection or protein immunization. In addition, expression of the TFH lineage–defining transcription factor Bcl6 was reduced in the absence of Mll1. Transcriptomics analysis identified Lef1 and Tcf7 as genes dependent on Mll1 for their expression, which provides one mechanism for the regulation of TFH differentiation by Mll1. Taken together, CRs such as Mll1 substantially influence TFH differentiation.
IL-18 Binding Protein–Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome
Authors: Harel Mathilde , Fauteux-Daniel Sébastien , Rodriguez Emiliana , Palmer Gaby , Gabay Cem 
Published: April 2023

Abstract
IL-18 is a pleiotropic immunoregulatory cytokine of the IL-1 family. IL-18 has been identified as a potent IFN-γ inducer in synergy with IL-12 and IL-15 and thus as a powerful Th1 cell–polarizing cytokine. IL-18 activity is regulated by its naturally occurring soluble inhibitor IL-18 binding protein (IL-18BP), the production of which is stimulated by IFN-γ in a negative feedback loop. Circulating levels of IL-18BP are elevated, and unbound bioactive free IL-18 is thus not detectable in the circulation in physiologic conditions. However, emerging evidence indicates that the IL-18/IL-18BP balance could be dysregulated in macrophage activation syndrome (MAS), as mirrored by the presence of free IL-18 in the circulation of patients with MAS. Herein, we sought to identify IL-18BP-producing cells in a murine CpG-induced MAS model using IL-18BP knock-in tdTomato reporter mice. Endothelial cells, tissue-resident macrophages, and neutrophils appeared as major cellular sources of IL-18BP. We also identified extramedullary and medullary early erythroid progenitors as IL-18BP-producing cells in an IFN-γ-dependent manner. This finding suggests a novel regulation of IL-18 activity by erythroid precursors, which are likely involved in the prevention of the negative effects of IL-18 on erythropoiesis. Indeed, coherent in vivo and in vitro results indicate that IL-18 indirectly impairs erythropoiesis while favoring myelopoiesis and thus contributes to anemia associated with MAS and potentially with other IL-18-driven inflammatory diseases. In conclusion, IL-18BP production by endothelial cells, neutrophils, macrophages, and erythroid precursors attenuates the anemia associated with murine CpG-induced MAS.
COVID-19 vaccine uptake and its determinants among teenagers and their parents in Zhejiang, China
Authors: Huang Yu , Wu Qingqing , Xu Shuiyang , Zhao Xiang , Wang Lei , Lv Qiaohong , Wu Suxian , Zhang Xuehai 
Published: April 2023

Objective:
To examine COVID-19 vaccine uptake and its determinants among teenagers and their parents in Zhejiang, China.

Methods:
An online cross-sectional study was conducted among parents of teenagers in Zhejiang, China from May 1 to 31, 2022. Data were interpreted via univariate and multivariate analyses using the statistical package for the social sciences (SPSS) program.

Results:
A total of 11115 (96.11%) participants and 11449 (99.00%) of their children in Zhejiang, China had been vaccinated against COVID-19. Children whose parents did not receive COVID-19 vaccination were 19 times (aOR 18.96, 95%CI 12.36-29.08) more likely to be unvaccinated than their counterparts. In addition, children with no previous influenza vaccination, those whose parents doubted the COVID-19 vaccine’s safety or effectiveness, were 6.11 times (aOR 6.11, 95%CI 2.80-13.34), 8.27 times (aOR 8.27, 95%CI 5.33-12.83), and 2.69 times (aOR 2.69, 95%CI 1.11-6.50) more likely to be unvaccinated than their counterparts, respectively. COVID-19 vaccine uptake varied between different sociodemographic groups. However, the odds of receiving the COVID-19 vaccine decreased as age and education level increased. The main refusal reasons claimed by participants were that they had medical conditions that may not qualify them for vaccination (53.78%), followed by safety concerns about the vaccine (13.56%), not knowing where to get vaccinated (6.44%), and concerns about fertility issues (5.56%).

Conclusions:
Despite a highly encouraging level of COVID-19 vaccine uptake in Zhejiang, China, the elderly and highly educated people had lower COVID-19 vaccine uptake. It is suggested that tailored health education strategies should be taken to increase the COVID-19 vaccine uptake in such groups. Furthermore, with vaccination rates at such a high level, the pandemic is still ongoing, and public confidence in vaccines may decline. Thus, sufficient evidence-based information regarding COVID-19 vaccines should be provided to the public.