bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice
Authors: Ullah Irfan , Escudie Fanny , Scandale Ivan , Gilani Zoela , Gendron-Lepage Gabrielle , Gaudette Fleur , Mowbray Charles , Fraisse Laurent , Bazin Renée , Finzi Andrés , Mothes Walther , Kumar Priti , Chatelain Eric , Uchil Pradeep D. 
Published: June 2023

SummaryDirect acting antivirals (DAAs) represent critical tools for combating SARS-CoV-2 variants of concern (VOCs) that evolve to escape spike-based immunity and future coronaviruses with pandemic potential. Here, we used bioluminescence imaging to evaluate therapeutic efficacy of DAAs that target SARS-CoV-2 RNA-dependent RNA polymerase (favipiravir, molnupiravir) or Main protease (nirmatrelvir) against Delta or Omicron VOCs in K18-hACE2 mice. Nirmatrelvir displayed the best efficacy followed by molnupiravir and favipiravir in suppressing viral loads in the lung. Unlike neutralizing antibody treatment, DAA monotherapy did not eliminate SARS-CoV-2 in mice. However, targeting two viral enzymes by combining molnupiravir with nirmatrelvir resulted in superior efficacy and virus clearance. Furthermore, combining molnupiravir with Caspase-1/4 inhibitor mitigated inflammation and lung pathology whereas combining molnupiravir with COVID-19 convalescent plasma yielded rapid virus clearance and 100% survival. Thus, our study provides insights into treatment efficacies of DAAs and other effective combinations to bolster COVID-19 therapeutic arsenal.
Professional skills development: foundational curriculum skills and competencies of UK construction management programmes
Authors: Posillico John , Edwards David , Roberts Chris , Shelbourn Mark 
Published: June 2023

PurposeThis research presents a profile of the current skills and competencies that underpin construction management programmes' (CMP) curricula within United Kingdom (UK) higher education institutes (HEIs). In doing so, the work: synthesises disparate taught provisions across a range of HEIs; conducts a cross-comparative analysis between these provisions and engenders wider discourse and new insight into the consistency of current higher education practice.Design/methodology/approachBoth interpretivism and pragmatism are adopted to analyse secondary data sourced from construction management undergraduate programmes in the UK inductive reasoning and inferential analysis (i.e. quantitative rank correlation, text/data mining and qualitative inquiry) are utilised to help underscore the current technical and interpersonal skills and competencies noted within the programmes and develop new theories on curriculum shortfalls and inadequacies.FindingsResearch findings demonstrate that the specific content of CMP are bespoke and tailored by the programme teaching team at each individual HEI; albeit, all programmes reviewed are in congruence regards the importance of broad technical and interpersonal themes. However, the degree to which these themes are publicly presented differ from the curricular and institutional documentation; specifically, a more “technical-based skill” image is being portrayed publicly whilst “interpersonal skills” are doing the heavy curriculum lifting. Hence, the foundational curriculum skills and competencies are firmly rooted in a sense of employability and career preparedness; a balance of technical and interpersonal skills. Identification of these skills and competencies provides a springboard for supplementary research to augment curriculum development.Originality/valueThis research constitutes the first attempt to conduct a cross-comparative analysis of descriptive metadata contained with curriculum development documents sourced from various UK HEIs. Emergent findings unearth the key skills and competencies that serve as the curriculum's foundation but also question whether a more consistent approach to construction management education should be sought.
Predictors of citizens' trust in public leadership in Ghana: a comparison between the president, MPs and MMDCEs
Authors: Dzordzormenyoh Michael K. 
Published: June 2023

PurposeThis study was designed to assess the predictors of citizens' trust in public leaders in Ghana. Specifically, it assesses the effect of eight trust variables—competence/ability, integrity, communication, benevolence, political/quality of governance, rational/economic, risk-taking and socio-demographic characteristics—on citizens' trust in public leaders—the president, members of parliament (MPs) and metropolitan, municipal and district chief executives (MMDCEs)—in Ghana from 2016 to 2018.Design/methodology/approachSummary statistics, bivariate correlation and binary logistic regression were employed to analyze 2,400 responses of Ghanaians obtained from the Afro-Barometer round seven surveys on Ghana (2016–2018).FindingsThe results reveal that competence/ability, that is to say, the performance of the president, MPs and MMDCEs, influence citizens' trust in these leaders. Furthermore, communication, benevolence, rationality, risk-taking and socio-demographic variables were significant predictors of citizens' trust in the president. Likewise, competence/ability, communication, politics, benevolence and socio-demographic variables were predictors of citizens' trust in MPs. Additionally, competence/ability, communication, integrity, politics, benevolence and socio-demographic variables influence citizens' trust in MMDCEs. In short, the rationality and risk-taking variables only influence trust in the president, while the political variables influence trust in MPs and MMDCEs. However, integrity influences trust in MMDCEs. Future studies can investigate the factors that account for these differences to augment the current literature.Originality/valueThis article is unique because it examines and compares citizens' trust in three categories of public leaders—the president, MPs and MMDCEs—in Ghana using nationally representative data.
On the nature of supply chain reliability: models, solution approaches and agenda for future research
Authors: Kumar Devesh , Soni Gunjan , Kazancoglu Yigit , Rathore Ajay Pal Singh 
Published: June 2023

Purpose This research aims to update the literature about the importance of reliability in supply chain (SC) and to find out the SC determinants.Design/methodology/approach This research surveys while contributing to the academic grasp of supply chain reliability (SCR) concepts. The study found 45 peer-reviewed publications using a structured survey technique with a four-step filtering process. The filtering process includes data reduction processes such as an evaluation of abstract and conclusion. The filtered study focuses on SCR and its determinants.Findings One of the major findings is that most of the study has focused on mathematical and conceptual studies. Also, this study provides the answer to a question like how can reliability be better accepted and evolved within the SC after finding the determinants of SCR.Originality/value The observed methodological gap in understanding and development of SCR was identified and classified into three categories: mathematical, conceptual and empirical studies (case studies and survey’s mainly). This research will aid academics in developing and understanding the determinants of SCR.
Standard deviation and rank sum-based MARCOS model under intuitionistic fuzzy information for hospital site selection
Authors: Hezam Ibrahim M. , Mishra Anand Kumar , Pamucar Dragan , Rani Pratibha , Mishra Arunodaya Raj 
Published: June 2023

PurposeThis paper develops a decision-analysis model to prioritize and select the site to establish a new hospital over different indicators such as cost, market conditions, environmental factors, government factors, locations and demographics. In this way, an integrated model is proposed under the intuitionistic fuzzy information (IFI), the standard deviation (SD), the rank-sum (RS) and the measurement of alternatives and ranking using the compromise solution (MARCOS) approach for ranking hospital sites (HSs).Design/methodology/approachThe IF-SD-RS model is presented to obtain the combined weight with the objective and subjective weights of diverse sub-criteria and indicators for ranking sites to establish the hospital. The IF-MARCOS model is discussed to prioritize the various sites to establish the hospital over several crucial indicators and sub-criteria.FindingsThe authors implement the developed model on a case study of HSs assessment for the construction of new hospital. In this regard, inclusive set of 6 key indicators and 18 sub-criteria are considered for the evaluation of HSs. This study distinguished that HS (h2) with combined utility function 0.737 achieves highest rank compared to the other three sites for the given information. Sensitivity analysis is discussed with different parameter values of sub-criteria to examine how changes in weight parameter ratings of the sub-criteria affect the prioritization of the options. Finally, comparative discussion is made with the diverse extant models to show the reasonability of the developed method.Originality/valueThis study aims to develop an original hybrid weighting tool called the IF-SD-RS model with the integration of IF-SD and IF-RS approaches to find the indicators' weights for prioritizing HSs. The developed integrated weighting model provides objective weight by IF-SD and subjective weight with the IF-RS model. The model presented in the paper deals with a consistent multi-attribute decision analysis (MADA) concerning the relations between indicators and sub-criteria for choosing the appropriate options using the developed IF-SD-RS-MARCOS model.
Editorial Gema Dari Menara (1968), Brunei’s first feature film
Authors: Daud Kathrina Mohd 
Published: June 2023

The film was a revelation to me because I was not aware of any visual record of such a culture in pre-independence Brunei. Until I saw the film, my impressions of Bruneian culture came mostly from hearsay and oral history […] to put it bluntly, Gema Dari Menara is not a very good film at all, but is nonetheless a time capsule of Brunei’s lost pop history.
Gema Dari Menara/ Echoes from the Minaret: A Conversation with Mervin Espina about the Lost Cinema of Brunei (Espina, 2013: 70)
Analysis of clock drift based on a three‐dimensional controlled‐source ocean bottom seismometer experiment
Authors: Zhang Jiazheng , Zhao Minghui , Yao Yongjian , Qiu Xuelin 
Published: June 2023

AbstractClock drift is common for the autonomous ocean bottom seismometer, and a technique of linear drift correction is usually used to fix this kind of timing error assuming that the internal clock has constant drift rate during deployment. However, non‐linear component of clock drift has also been found recently. In order to test the behaviours of the clock drift for 19 Chinese ocean bottom seismometers from a three‐dimensional controlled‐source seismic survey, we have analysed two types of differences in direct wave travel‐times, including one from all shots to the ocean bottom seismometer onboard and another one from the nearest two shots on different shooting lines to the ocean bottom seismometer on the seafloor. Comparison of the differences in direct wave travel‐times from seismic data with and without clock drift correction shows that linear drift correction can commendably eliminate them for most of the ocean bottom seismometers, but some large residuals remain for part of the ocean bottom seismometers. These residuals are inferred to be possibly related to the non‐linear component of clock drift caused by the temperature shock during deployment. The non‐linear clock drift usually varies from different ocean bottom seismometers and thus difficult to correct completely and resultantly will influence the timing accuracy somewhat. Hence, higher uncertainties are suggested to assign to the picked travel‐times for the ocean bottom seismometer with possibly larger non‐linear clock drift in the further tomographic modelling and the internal clock for this kind of ocean bottom seismometer should be recalibrated prior to the next experiment if which requires higher timing accuracy.
Associations of state and trait empathy with daily alcohol use
Authors: Kumar Lakshmi , Ringwald Whitney R. , Wright Aidan G. C. , Creswell Kasey G. 
Published: June 2023

AbstractBackgroundA growing literature documents associations between lower trait empathy and heavier alcohol use and more alcohol problems in adolescent and young adult samples. Prior work linking empathy and alcohol use/problems in these populations has thus far focused on trait rather than state empathy, and researchers often do not differentiate between cognitive and affective empathy. Further, no prior studies have examined associations between daily fluctuations in state empathy and alcohol use. The goal of the current study is to advance knowledge about the associations between state (vs. trait) and cognitive (vs. affective) empathy and alcohol use.MethodsAdult alcohol drinkers (n = 492; Mage = 22.89, SD = 5.53; 53.70% female) participated in ecological momentary assessment studies for 7 to 10 days (day n = 4683). Multilevel hurdle models were used to investigate associations between day‐level state empathy and daily alcohol use at the within‐person level, and associations between individual differences in trait empathy and alcohol use across days at the between‐person level.ResultsHigher day‐level state affective empathy was not associated with the likelihood of drinking on a particular day, but it was significantly associated with a greater number of drinks consumed on alcohol‐consuming days, with the latter associations remaining after controlling for day‐level positive affect (PA) and negative affect (NA). No associations were found for day‐level state cognitive empathy, or trait affective or cognitive empathy.ConclusionsOn drinking days, when individuals reported more affective empathy than is typical for them, they were more likely to consume a greater number of alcoholic drinks, results that remained when controlling for levels of PA and NA. Daily shifts in affective empathy may be important to consider in efforts to understand alcohol use.
Asia‐Pacific Leukemia Consortium: An innovative and collaborative initiative to improve care of leukemia and related diseases in the Asia‐Pacific region
Authors: Lao Zhentang , Tse Eric Wai Choi , Chuncharunee Suporn , Kwong Yok Lam , Wei Andrew , Ko Bor Sheng , Kim Jin Seok , Ng Soo Chin , Wang Jianxiang , Goh Yeow Tee 
Published: June 2023

AbstractThe burden of leukemia and related diseases is rapidly growing in Asia. Currently, there is a paucity of regional collaborative groups/initiatives that focus exclusively on the management of leukemia in the Asia‐Pacific (APAC) region. The Asia‐Pacific Leukemia Consortium (APLC) was established on the 8 September 2021 to understand the status quo, unmet needs, and ways to improve the management of leukemia and related diseases in the APAC region. The APLC working group set up a group of experts from various countries (Singapore, Malaysia, Thailand, Hong Kong, Japan, South Korea, Taiwan, China, and Australia) to discuss on the status of: (i) clinical trials; (ii) disease registry database; (iii) genetic and tissue repository; (iv) patient advocacy and care; and (v) disease prevention and education in the APAC region. Low levels of awareness about leukemia amongst the public, lack of financial support, and limited access to newly approved therapies were identified as barriers to the implementation of effective leukemia management in low‐ or mid‐income Asian countries. Patients often enroll in clinical trials to gain access to novel/approved therapies. The APLC group aims to address the growing threat of leukemia through a collaborative approach to advance disease prevention, research, clinical trials, and education.
Intracytoplasmic sperm injection vs. in‐vitro fertilization in couples in whom the male partners had a semen analysis within normal reference ranges: An open debate
Authors: Sciorio Romualdo , Fleming Steven D. 
Published: June 2023

AbstractDuring recent decades, the application of intracytoplasmic sperm injection has increased considerably worldwide, especially in couples with non‐male factor infertility. However, several studies analyzing the broad use of intracytoplasmic sperm injection, even in cases with a normal semen analysis, have collectively demonstrated no benefits compared to conventional in‐vitro fertilization. Currently, there is insufficient evidence to support the intracytoplasmic sperm injection technique vs. in‐vitro fertilization in cases of poor ovarian response or a low number of oocytes collected, or in patients with advanced maternal age. Since the intracytoplasmic sperm injection technique is more operator‐dependent and invasive, its use should only be recommended in cases of male‐factor infertility. There is some evidence showing that intracytoplasmic sperm injection is linked with an increased risk of birth defects. Albeit this evidence is limited, and currently it is not possible to draw a firm conclusion on these concerns, we do believe that these risks should be rigorously investigated. Thus, this review aims to clarify the debate on the application of the intracytoplasmic sperm injection procedure, as compared to standard in‐vitro fertilization, in those assisted reproductive technology cycles without a clear male factor infertility. Furthermore, we try to clarify whether intracytoplasmic sperm injection would result in a higher live birth rate than in‐vitro fertilization, in couples with non‐male factor infertility.
Towards a Political Economy of Social Infrastructure: Contesting “Anti‐Social Infrastructures” in London
Authors: Horton Amy , Penny Joe 
Published: June 2023

AbstractIn this paper, we develop a situated and intersectional urban political economy approach to social infrastructure. This approach contrasts with a growing body of liberal urban geography, which offers an optimistic account of how shared spaces afford encounter and social connection. We present four arguments about why such outcomes cannot be assumed, which are informed by a case of contested redevelopment in the London borough of Haringey. First, social infrastructures express power relations, enacting distinct visions of “the social”, that are at times premised on the denigration of other forms of collective life as anti‐social. Second, elite social infrastructures are increasingly central to speculative urban development, serving to procure consent for, and valorise, investment. Third, other social infrastructures are essential networks of social reproduction and survival, especially for diverse working‐class communities: demolition and displacement mean infrastructural disruption. Finally, unequal political economies of social infrastructure are a realm of structural antagonism over urban citizenship (un)making.
The economics of artificial organs
Authors: Shah Aakash M. 
Published: June 2023

SummarySpurred by devoted research and institutional financing, organ replacement therapies have progressed monumentally over the last century. Concomitantly, there has been an escalation in healthcare costs. In an aging society where organ replacement therapy utilization is expected to continue to rise, will society need to rethink the economics of end‐stage organ dysfunction management?
A prospective comparison of UK and Malaysian patients with irritable bowel syndrome in secondary care
Authors: Chuah Kee‐Huat , Black Christopher J. , Tee Vincent , Lim Sze‐Zee , Hian Wen‐Xuan , Sahran Nur‐Fazimah , Lee Yeong‐Yeh , Mahadeva Sanjiv , Ford Alexander C. 
Published: June 2023

SummaryBackgroundThe prevalence of irritable bowel syndrome (IBS) is now known to be similar in various geographical regions, but there has been no study directly comparing characteristics of patients with IBS between populations.AimsTo evaluate clinical and psychological differences between adults with IBS seen in secondary care in the United Kingdom (UK) and Malaysia.MethodsAge‐ and sex‐matched patients with IBS from a single centre in the UK (Leeds) and two centres in Malaysia (Kuala Lumpur and Kota Bharu), who fulfilled Rome III criteria, were recruited prospectively. Demographic characteristics and gastrointestinal and psychological symptoms were compared between both groups.ResultsA total of 266 (133 UK and 133 Malaysian) age‐ and sex‐matched patients with Rome III IBS were recruited (mean age: 45.1 years Malaysia, vs. 46.5 years UK; 57.9% female). UK patients were more likely to consume alcohol than Malaysian patients (54.1% vs. 10.5%, p < 0.001). Compared with Malaysian patients, UK patients had more frequent abdominal pain, abdominal bloating, meal‐related symptoms (p < 0.001 for all), higher symptom scores (mean 268.0 vs 166.0; p < 0.001), greater limitation of activities due to IBS (p = 0.007) and were more likely to report abnormal anxiety scores (p < 0.001). Higher perceived stress (mean 21.3 vs. 19.1, p = 0.014) and gastrointestinal symptom‐specific anxiety scores (mean 50.8 vs. 43.0, p < 0.001) were also observed in UK patients. Finally, UK patients had higher somatoform symptom‐reporting scores (mean 8.9 vs. 6.9, p < 0.001).ConclusionsIBS is more severe and is associated with a higher level of psychological symptoms in the UK compared with Malaysian patients in secondary care.
Antenatal cardiotocography in primary midwife‐led care: Women's satisfaction
Authors: Neppelenbroek Elise M. , Ammerlaan Anouk J. M. , van der Heijden Olivier W. H. , van der Pijl Marit S. G. , Kaiser Anouk , de Jonge Ank , Verhoeven Corine J. M. 
Published: June 2023

AbstractBackgroundIn the Netherlands, antenatal cardiotocography (aCTG), used to assess fetal well‐being, is performed in obstetrician‐led care. To improve continuity of care, an innovation project was designed wherein primary care midwives perform aCTGs for specific indications. The aim of this study was to examine the satisfaction and experiences of pregnant women who received an aCTG in primary midwife‐led care and explore which factors were associated with high satisfaction.MethodsData were collected through a self‐administered questionnaire based on the Consumer Quality Index. The primary outcome was general satisfaction on a 10‐point scale, with a score above nine indicating participants were “highly satisfied”.ResultsIn total, 1227 women were included in the analysis. The study showed a mean general satisfaction score of 9.2. Most women were highly satisfied with receiving an aCTG in primary midwife‐led care (77.4%). On the Consumer Quality Index, the mean satisfaction level varied from 3.98 (SD ± 0.11) for the subscale “client satisfaction” to 3.87 (SD ± 0.32) for the subscale “information provision” on a 4‐point scale. Women at between 33 and 36 weeks' gestation were more likely to be highly satisfied (adjusted OR [aOR] = 3.35). Compared with a completely comfortable position during the aCTG, a mostly comfortable or somewhat comfortable level had decreased odds of being associated with a ranking of highly satisfied (aOR 0.24 and 0.19, respectively).ConclusionsThis study shows that pregnant women are satisfied with having an aCTG in midwife‐led care. Providing aCTG in midwife‐led care can increase access to continuity of care.