bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic resections or observation in management of sporadic non-functioning stage T1 neuroendocrine tumors of the pancreas (PNET) (literature review)
Authors: Salimgereeva D. A. , Feidorov I. Y. , Khatkov I. E. 
Published: July 2023

The availability of modern high-precision diagnostic methods increased the detection rate of pancreatic neuroendocrine neoplasia (pNEN). There is no doubt concerning the necessity of surgical treatment for localized functioning tumors, whilecurrently there is no objective way to choose the tactic for non-functioning asymptomatic neuroendocrine tumors of the pancreas (pNET) with the exception of the tumor size.Treatment tactics for non-functioning asymptomatic T1 neuroendocrine tumors (less 2 cm in size) are debatable. According to literature surgical treatment for lesions less than 2 cm does not always increase survival. In the same time even in high-volume centers pancreatic surgery shows high morbidity and mortality rate. Prospective randomized trials comparing surveillance and operative treatment are not published yet, as far as authors concerned. International guidelines answer the question of treatment such neoplasms ambiguously, while national Russian recommendations do not cover the topic. Guidelines are based on heterogeneous retrospective studies; therefore, the aim of scientific research is to determine reliable criteria for patient selection for dynamic observation or surgical treatment.This article provides an overview of 60 scientific publications covering the problem.
[18F]Fluoromisonidazole synthesis method: development and optimization by cartridge purification
Authors: Chochevska Maja , Lazareva Marija Atanasova , Kolevska Katerina , Velichkovska Maja , Koziorowski Jacek , Ivanovska Emilija Janevik , Angelovska Bistra , Ugrinska Ana 
Published: July 2023

Abstract
[18F]Fluoromisonidazole ([18F]FMISO) as nitroimidazole derivative with 18F radioisotope is a widely known and studied hypoxia marker for PET imaging. A number of automated synthesis modules and purification strategies for production of [18F]FMISO have been described in recent years. The goal of this work was to develop [18F]FMISO synthesis process with Synthera module with solid phase extraction (SPE) Sep-Pak purification cartridges. To adjust the reaction conditions we synthesized [18F]FMISO under different reaction conditions and using various reversed-phase (RP) purification cartridges (HLB light, HLB plus, tC18, C18 environmental, Chromafix PS-RP). The synthesis was performed by nucleophilic substitution of commercial 1-(2′-nitro-1′-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonylpropanediol precursor and subsequent acidic hydrolysis. Further, the product mixture was purified by passing through the SPE cartridge. The produced [18F]FMISO was retained on the cartridge, while the impurities passed through the cartridge into a waste. The retained [18F]FMISO was then eluted with small amounts of ethanol in water and eluates were collected in the final product vial. The product sample was subjected to quality control tests, while for waste sample chemical and radiochemical tests were performed. We have developed an efficient synthesis method of [18F]FMISO with cartridge purification with good radiochemical yield (RCY) and high chemical and radiochemical purity in accordance with the Ph. Eur. Monograph for Fluoromisonidazole (18F) injection.
Primary Reference Procedure for Measuring the Mass Fraction and Molar Concentration of Copper and Zinc in Biological Materials by Isotope Dilution Mass Spectrometry
Authors: Vostroknutova E. V. , Tabatchikova T. N. , Migal P. V. , Lebedeva E. L. , Sobina E. P. , Sobina A.  V. , Kuznetsova M. F. 
Published: July 2023

The establishment and control of the metrological characteristics of the determination of trace elements in biological materials is an urgent task due to the wide application of these measurements in medical laboratory diagnostics. In the course of the research, the process of developing a primary reference procedure for measuring the mass fraction and molar concentration of copper and zinc in biological materials by isotope dilution mass spectrometry is presented. The optimal conditions for sample preparation and measurements by isotope dilution and mass spectrometry with inductively coupled plasma are determined in order to increase the accuracy. The sources of uncertainty are studied; the contribution of each source to the uncertainty budget is estimated. During the certification of the developed measurement procedure, the following metrological characteristics were determined: the measurement range of the mass fraction of copper and zinc is from 1 ∙ 10–6 to 1,5 ∙ 10–3 %, the measurement range of the molar concentration of copper and zinc is from 2 to 20 µmol/dm3, the relative expanded measurement uncertainty of the mass fraction of copper is (7.1–7.5) %, the relative expanded uncertainty of the mass fraction of zinc is (8.9–9.2) %, the relative expanded uncertainty of the molar concentration of copper is 8.8 %, the relative expanded uncertainty of the molar concentration of zinc is 8.6 %.The developed procedure is intended to establish the metrological characteristics of reference materials for the composition of lyophilized blood serum and reconstituted lyophilized blood serum, control the accuracy of the measurement results obtained using other procedures (methods) of measuring similar values, perform high-precision measurements of mass fractions and molar concentrations of copper and zinc in lyophilized blood serum and reconstituted lyophilized blood serum for referee purposes.
Altered purinergic signaling in women undergoing cardiac surgery under cardiopulmonary bypass
Authors: Cassavaugh Jessica , Khan Adnan A. , Qureshi Nada , Valencia Juan , Mahmood Eitezaz , Russ Elizabeth , Sohail Ahmed , Poulin Marie-France , Bose Ruma , Khabbaz Kamal , Mahmood Feroze , Robson Simon C. , Matyal Robina 
Published: July 2023

Abstract
Despite recent advances in cardiac surgery, adverse outcomes remain more prevalent in females as compared to males. Our study aimed to further understand whether purinergic signaling plays a role in the discrepancy in outcomes of females presenting for cardiac surgery. Right atrial tissue was harvested from 80 patients undergoing cardiac surgery before and after and cardiopulmonary bypass (CPB). Human tissue experimentation was complemented by experiments in 40 mice subject to a high fat diet and ovariectomy. Females had clinically significant increased incidence of diastolic dysfunction, length of stay, and fibrosis as well as significantly increased markers of inflammation (IL-6, leptin), apoptosis, and oxidative stress. Western blotting demonstrated that CD39, responsible for the enzymatic lysis of inflammatory extracellular ATP, was significantly decreased in women post-bypass when compared to men (P < 0.05). CD73 expression was significantly higher pre-bypass with decreased expression of adenosine deaminase post-bypass in women, suggestive of perturbed adenosine homeostasis (p < 0.05). Our experimental mice model demonstrated cardiac dysfunction and changes in purine-adenosine signaling pathways correlating to significantly decreased adenosine levels in high-fat diet and ovariectomy groups compared to control (p < 0.05). Our findings suggest that the imbalance of pro-inflammatory ATP and adenosine may play a role in sex-specific outcomes in cardiac surgery.
CReToNeXt-YOLOv5: A study on the construction of pig face expression recognition
Authors: Nie Lili , Jiao Fan , Song Xinyue , Du Yihan , Liu Zhenyu 
Published: July 2023

Abstract
The study focused on the significance of facial expressions in pigs as a mode of communication for assessing their emotions, physical status, and intentions. To address the challenges of recognizing facial expressions due to the simple facial muscle group structure of pigs, a novel pig facial expression recognition model called CReToNeXt-YOLOv5 was proposed. Several improvements were made to enhance the accuracy and detection ability of the model. Firstly, the CIOU loss function was replaced with the EIOU loss function to optimize the training model and achieve more accurate regression. This change improved the overall performance of the model. Secondly, the model was equipped with the Coordinate Attention mechanism, which improved its sensitivity to expression features, making it more effective in recognizing facial expressions. Lastly, the CReToNeXt module was integrated into the model to enhance its detection capability for subtle expressions. The results demonstrated the effectiveness of the CReToNeXt-YOLOv5 model. It achieved a mean average an mAP of 89.4%, showing a significant improvement of 6.7% compared to the original YOLOv5 model. Overall, the experimental results confirmed the effectiveness of the optimized YOLOv5 model, CReToNeXt-YOLOv5, in accurately recognizing facial expressions in pigs.
Why rivers disappear - analysis of postmining factors using the example of the Sztoła River, Poland.
Authors: Lupa Michał , Pełka Aleksandra , Młynarczuk Mariusz , Adamek Katarzyna 
Published: July 2023

Abstract
This study examines the drought in the Olkusz region using satellite imagery and remote sensing indices. The analysis reveals that the region experienced multiple types of drought, including hydrogeological drought due to groundwater level lowering caused by mining activities, agricultural drought resulting from insufficient soil moisture, hydrological drought characterized by reduced water flow in rivers, and meteorological drought linked to decreased precipitation and high temperatures. The study demonstrates the usefulness of optical imaging and remote sensing indices such as NDVI, MSAVI2, MSI, NDWI, and NMDI in monitoring and assessing drought conditions. The results indicate significant changes in vegetation health and water content, as well as alterations in the natural environment within the region. The research highlights the importance of considering both human-induced and natural factors when evaluating drought phenomena. Continued monitoring and expansion of the study area would provide valuable insights into the long-term effects of weather conditions and the broader impacts on the ecosystem.
High-resolution downscaled climate variables spatiotemporal variation and drought projected in the Sanjiang Plain, Northeast China
Authors: Huang Peng , Xie Hua , Li Dan , Hu Xuhua , Liu Chaoli , Xu Yang , Song Changhong , Dai Chunsheng , Khan Shahbaz , Cui Yuanlai , Luo Yufeng 
Published: July 2023

Abstract
Drought is greatly impacted by climate variables, and high-resolution downscaled climate variables are valuable for precisely identifying drought characteristics. Due to Sanjiang Plain’s crucial strategic position and drastic climate changes, we analyze its spatiotemporal variation in climate variables and standardized precipitation evapotranspiration index (SPEI). Two sharing economy pathway scenarios (SSP245 and SSP585) during the early (2023–2030), middle (2050–2060), and late periods (2090–2100) are projected. The Weather Research and Forecasting (WRF) and Statistical Downscaling Model (SDSM) are used for downscaling to simulate temperature and precipitation, respectively. WRF model is driven by the bias-corrected CMIP6 dataset, the ensemble of CMIP6 daily predictor variables are applied to SDSM, which generate high-resolution downscaled data named SSP-DS scenario. The SPEI computed from precipitation and reference evapotranspiration (ET0) is adopted to identify drought characteristics. The results indicate that downscaled results accurately reflect the CMIP6 original outputs change trend, but increase ET0 and reduce precipitation. The average temperature, total ET0, total precipitation manifests an increasing trend over time, and SSP585-DS scenario increases more significantly. High radiative forcing contributes to increasing temperature and ET0. Seven stations dry and wet characteristics have no obvious spatial heterogeneity; accumulated16 to 23 (17 to 24) drought events are captured, mild drought is the most frequent and extreme drought is the least under the SSP245-DS and SSP585-DS scenario. This study predicts the spatiotemporal variation in climate variables and drought characteristics based on high-resolution downscaled data, which contributes to Sanjiang Plain management strategy against drought risk and climate change.
The Value of Advanced Cardiac Magnetic Resonance Imaging Technologies in Detecting the Characteristics of Cardiac Involvement in Anderson-Fabry Disease
Authors: Yang Junlan , Wei Zhiyuan , Li Zuolin , Yang Yan , Shi Xuan , Cao Jingyuan , Yu Weiwei , Zhang Shijun , Zhang Aihua , Zhang Xiaoliang , Wang Bin 
Published: July 2023

Abstract

Introduction: Anderson-Fabry disease (AFD) is a genetic disorder associated with cardiac involvement. Advanced cardiac magnetic resonance (CMR) technologies, including T1 mapping and gadolinium-enhanced CMR, have been used to detect and evaluate cardiac involvement in AFD patients. However, there is limited information on the characteristic CMR manifestations of cardiac involvement in Chinese AFD patients.
Methods: In this cross-sectional study, clinical data were collected from patients with AFD diagnosed at this center from January 2022 to March 2023. Compared with echocardiography, CMR was used to evaluate cardiac function, the degree of cardiac structural lesions, and to analyze characteristic CMR findings of cardiac involvement in AFD.
Results: 20 patients with AFD from nine families were included. This study showed that left ventricular hypertrophy (LVH) was detected in 85% of patients (18.41 ± 4.56 mm) by CMR, whereas echocardiography identified LVH in only 65% of patients (16.86 ± 2.74 mm), suggesting that echocardiography may underestimate the severity of LVH in AFD patients (P=0.001). Moreover, all patients exhibited characteristic CMR findings of cardiac involvement in AFD, including decreased T1 values (95% of patients) and late gadolinium enhancement (LGE) associated with myocardial fibrosis (55% of patients).
Conclusion: This study demonstrated that CMR is a valuable tool for detecting and assessing cardiac involvement in AFD patients, providing characteristic CMR findings, including LVH, decreased T1 values, and LGE associated with myocardial fibrosis. Moreover, this study highlighted the diagnostic superiority of CMR over echocardiography in assessing LVH in AFD patients.
Neuropeptide W Facilitates Chronic Gastric Ulcer Healing by the Regulation of Cyclooxygenase and NF-κB Signaling Pathways
Authors: Tamer Sevil Arabacı , Mermer Sezen , Erdoğan Ömer , Çevik Özge , Ercan Feriha , Bağcı Cahit , Yeğen Berrak Ç. , Yeğen Berrak Ç. 
Published: July 2023

Abstract
Putative beneficial effects of NPW in the early phase of gastric ulcer healing process and the involvement of cyclooxygenase (COX) enzymes were investigated in an acetic acid-induced gastric ulcer model. In anesthetized male Sprague-Dawley rats, acetic acid was applied surgically on the serosa and then a COX inhibitor (COX-2-selective NS-398, COX-1-selective ketorolac, or non-selective indomethacin; 2 mg/kg/day, 3 mg/kg/day or 5 mg/kg/day; respectively) or saline was injected intraperitoneally. At 1-h of ulcer induction, omeprazole (20 mg/kg/day), NPW (0.1 µg/kg/day) or saline was intraperitoneally administered. Injections of NPW, COX inhibitors, omeprazole or saline were continued for the following 2 days until they were decapitated at the end of the third day. NPW treatment depressed the gastric PGI2 level, but not PGE2 level. Similar to omeprazole, NPW treatment significantly reduced the gastric and serum TNF-α and IL-1β levels and depressed the upregulation of NF-κB and COX-2 expressions due to ulcer. In parallel with the histopathological findings, treatment with NPW suppressed ulcer-induced increases in myeloperoxidase activity and malondialdehyde level and replenished glutathione level. However, the inhibitory effect of NPW on myeloperoxidase activity and NPW-induced increase in glutathione were not observed in the presence of COX-1 inhibitor ketorolac or the non-selective COX-inhibitor indomethacin. NPW facilitated the healing of gastric injury in rats via the inhibition of pro-inflammatory cytokine production, oxidative stress and neutrophil infiltration as well as the downregulation of COX-2 protein and NF-κB gene expressions.
Identification of Shared Pathogenetic Genes in Parkinson’s Disease and Type 2 Diabetes
Authors: Chen Lin , Wang Yong , Hu Binbin , Huang Juan , Huang Wei 
Published: July 2023

Abstract
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder. Increasing evidence suggests that PD patients have alterations in glucose metabolism and that type 2 diabetes (T2D) is a risk factor for PD. Although extensive literature has shown that there is a close linkage between PD and T2D, the molecular and genetic mechanisms of these two diseases are still unclear.
Object: The aim of this study was to explore the shared pathogenetic genes in PD and T2D. Method: We downloaded microarray data for PD and T2D from the Gene Expression Omnibus (GEO) database. The RNA microarray data of human postmortem substantia nigra samples were accessed from the GSE49036, GSE20141 and GSE7621 datasets. The RNA microarray data of human pancreatic islet samples were from the GSE76896 dataset. The differentially expressed genes between the PD/control and T2D/control groups were analyzed. Gene coexpression modules related to PD and T2D were constructed by weighted gene coexpression network analysis (WGCNA). Then, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed on the common genes between the PD and T2D key modules. Finally, through protein‒protein interaction (PPI) network analysis, four shared pathogenetic genes were identified.
Result: There were 348 downregulated differentially expressed genes and 221 upregulated differentially expressed genes between PD patients and healthy controls. There were 218 downregulated differentially expressed genes and 65 upregulated differentially expressed genes between T2D patients and healthy controls. Thirty-six common differentially expressed genes with consistent fold change directions were obtained from the overlapping differentially expressed genes between the PD and T2D datasets. In the PD datasets, the turquoise module was the key module related to the pathogenesis of PD and included 3735 genes. In the T2D dataset, the turquoise module was the most significant module related to the pathogenesis of T2D and included 790 genes. The common genes between the PD and T2D key modules were primarily enriched in synaptic transmission and insulin signaling. After the construction of the PPI network, we identified four shared pathogenetic genes, namely, TAGLN3, STMN2, SYT4 and GAP43.
Conclusion: In conclusion, TAGLN3, STMN2, SYT4 and GAP43 were the shared pathogenetic genes of PD and T2D, which might provide new therapeutic targets for PD and T2D.
Expression profiles of nintedanib-targeting molecules in progressive fibrotic interstitial lung diseases (non-IPF-PF) and IPF
Authors: Zhang Lanlan , Wang Pengbo , Mo Yan , Zhang Yuansheng , Tong Xia , Zhang Xin , Li Shasha 
Published: July 2023

Abstract
Background:
Idiopathic pulmonary fibrosis (IPF) and other types of progressive fibrotic interstitial lung diseases (non-IPF-PF), such as chronic hypersensitivity pneumonitis (cHP), systemic sclerosis (SSc), non-specific interstitial pneumonia (NSIP), and sarcoidosis, are common interstitial lung diseases. Nintedanib is one of the two approved therapies that can significantly slow the progression of IPF. However, the potential of nintedanib in non-IPF-PF has not been fully evaluated.
Methods:
We reanalyzed the single-cell data of IPF and non-IPF-PF and identified the main target genes of nintedanib (FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, and PDGFRA) by subgroup classification and functional analysis of gene expression profiles in both IPF and non-IPF-PF.
Results:
We found that the main target genes of nintedanib were upregulated in IPF and various cell subpopulations of non-IPF-PF, including cHP, SSc, NSIP, and sarcoidosis, with Fgfr1 being the most elevated subpopulation. In fibroblasts, Fgfr1 was found to be elevated in both IPF and cHP. We identified nintedanib-sensitive cell subpopulations by analyzing the expression profiles of fibroblasts after nintedanib treatment. We also found that nintedanib could inhibit the nintedanib-sensitive gene set in mice treated with nintedanib in vivo. Furthermore, we demonstrated that key regulatory genes of nintedanib were positively correlated with survival in lung adenocarcinoma, providing further support for the potential anti-tumor activity of nintedanib in vivo.
Conclusion:
Our findings provide comprehensive evidence of the target expression of nintedanib in non-IPF-PF and IPF, highlighting the potential of nintedanib for the treatment of non-IPF-PF.
Investigation of Supercapacitor Properties using Iron Tungsten Porous Electrode in Neutral Aqueous Electrolyte
Authors: Costa Maria Joseíta dos Santos , Costa Gilson dos Santos , Santos Reginaldo da Silva 
Published: July 2023

Abstract
Porous supercapacitors (SCs) materials are great interesting for energy storage system. Electrolyte contributes for enhancement supercapacitor perform. This paper, iron tungstate mixed oxides electrode was prepared by polymeric precursor method and deposited onto conductor substrate by drop casting heat-treated at 500 ºC for 2 h. The thermal, structural, and morphological characterization was realized by differential scanning calorimetry (DSC), X-ray diffraction (XRD), micro-Raman, emission–scanning electron microscopy (FE-SEM), atomic force microscopy (AFM), respectively. Crystallization process of polymeric resin occurred at 454°C. Synergistic effect of monoclinic FeWO4 and monoclinic Fe2W3O12 phases were confirmed with Fe/W mixed oxides. An irregular shape of condensed spherical-like particles aggregated with rough and porous nanostructures were observed. Neutral electrolytes were employed in electrochemical measurement as lithium nitrate (LiNO3) and sodium sulfate (Na2SO4). SC electrochemical analyses of Fe-W electrode accomplishes a capacitance of 75 F g–1 at 5 mV s–1, energy density of 3.73 Wh kg–1, power density of 582.1 W kg− 1and long-term electrochemical cycling with a capacity retention of 94.04% after 6000 cycles in 0.1 mol L− 1 Na2SO4. Therefore, Fe-W based electrode demonstrates a potential supercapacitor device with excellent stability in a nontoxic aqueous electrolyte.
Towards Task Mapping Approaches in Network on Chips: A Comprehensive Survey
Authors: masdari Mohammad 
Published: July 2023

Abstract
One of the main stages of Network on Chip (NoC) is task mapping where the application tasks are mapped to the processing resources. Task mapping decisions have a direct impact on the NoC performance and can be classified as static or dynamic mapping methods. In this paper, we carry out a comprehensive systematic study of task mapping schemes in various NoCs. For this purpose, firstly, an overview of the task mapping's main concepts is presented. Then, a taxonomy of the mapping schemes regarding their objectives and applied mapping factors is presented and the studied schemes are categorized into fault-tolerant schemes, congestion-aware schemes, communication-aware approaches, temperature-aware methods, and energy-aware schemes. Afterward, their main contributions, provided services, and drawbacks of the proposed studies in the literature are illustrated. Moreover, a comprehensive discussion of various features of the investigated mapping methods is presented and issues such as the applied algorithms, simulators, datasets, and evaluation metrics are discussed. Finally, the concluding issues and open research areas are highlighted.