bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing health and well-being: unlocking the speed abilities of 9-year-old primary school children
Authors: Mameshina Margarita , Cieślicka Mirosława 
Published: June 2023

Background and Study Aim. Physical activity is the key to fostering healthy growth and development in children. Encouraging children to engage in activities that enhance their speed abilities not only boosts their physical fitness but also contributes to their mental and emotional well-being. The purpose of the study - exploring speed abilities: a comparative study of 9-year-old primary school children in Ukraine and beyond.
Materials and Methods. The study was conducted at Kharkiv Central Educational School № 105 in Ukraine. A total of 29 children from the 4th grade (17 boys and 12 girls) participated in the study. These children were previously screened by a medical practitioner and were found to be in good health. Informed consent was obtained from the parents or guardians of the children, emphasizing their voluntary participation and the potential benefits and risks associated with the study. The study focused on assessing the speed abilities of the participating children. The tests included: 1) Running 30 meters (The time taken by each participant to run a distance of 30 meters was recorded in seconds); 2) Jumping rope (The number of times each participant successfully completed jumping rope within one minute was measured).
Results. The study revealed that the general level of development of speed abilities among the participating children corresponded to the average level observed for this age group. Jumping Rope Results: 1) Boys - the average number of successful jumps per minute was 74.94 ± 13.85; 2) Girls - the average number of successful jumps per minute was 76.00 ± 28.16. 30-Meter Run Results: 1) Boys - the average time taken to complete the run was 6.64 ± 0.10 seconds; 2) Girls - the average time taken to complete the run was 6.63 ± 0.11 seconds.
Conclusions. The findings of this study contribute to the existing body of knowledge on the speed abilities of 9-year-old primary schoolchildren, offering valuable insights for educators, researchers, and policymakers. Understanding the specific performance levels of boys and girls in jumping rope and running can inform the development of targeted interventions and programs aimed at enhancing speed-related skills among this age group.
Okan Yeşilot – Bihter Gürışık Köksal (ed.), Türk Tarihinin Kadim Şehirleri, Selenge Yayınları, İstanbul 2022, 600 s. (ISBN: 978-625-7459-97-6).
Authors: GÜNEŞ Mehmet 
Published: June 2023

Şehir ve medeniyet kavramları arasında kop(arıl)maz bir bağ vardır. Geçmişten bugüne medeniyetler şehirleri kurar, şehirler medeniyetlerin sembolleri olur. Kadim şehirlerin oluşumu uzun bir süreç almıştır. Dünya üzerinde geniş bir coğrafyaya yayılan Türkler, tarihin farklı dönemlerinde inşa ettikleri şehirlere kendi mühürlerini vurmuşlardır. Öyle ki bu şehirlerden bazıları Türklerin hâkimiyetinden çıksa da ruhlarına sinen Türk-İslam kimliği asla silin(eme)mektedir.
Okan Yeşilot ile Bihter Gürışık Köksal’ın editörlüğünde hazırlanan Türk Tarihinin Kadim Şehirleri adlı kitap , Müslüman Türk medeniyetinin mührünü taşıyan, mimarisinde ve silüetinde Türk-İslam medeniyetinin izleri belirgin biçimde hissedilen Medine’den Kazan’a, Buhara’dan Bosna’ya medeniyet şehirlerine ilişkin kısa monografilerden oluşmaktadır. Özbekistan Bilimler Akademisi’nden Azerbaycan Millî İlimler Akademisi’ne, Al-Farabi Kazak Milli Üniversitesi’nden Saraybosna Uluslararası Üniversitesi’ne çağdaş Türk dünyasının birçok şehrinden/üniversitesinden akademisyenin katkıda bulunduğu bu kitap; şehir tarihi, kültür ve medeniyet tarihi alanları başta olmak üzere birçok disiplin için başucu kaynağı olacaktır.
Physical and mental morbidity pattern among female cashew workers in Kollam district, Kerala
Authors: Rebello Mary Dello , Jose Betsy A. , Johns Felix 
Published: June 2023

Background: The cashew processing is a labour-intensive work with a significant number of female workers. Majority belong to low socioeconomic status and so they join this sector to meet up their daily living. Long hours of work, greater work load and increased family burden lead to increase in morbidity status among workers. As comorbidities gets unnoticed and ignored, there is occurrence of early morbidity as well as mortality in these working groups and this is one of the major concerns.
Methods: Cross-sectional study was conducted among female cashew workers in Kollam district, Kerala. Data was collected using interviewer administered questionnaire using stratified multistage cluster sampling method. Seven workers each were selected from shelling, peeling and grading processing units from eight private and two government factories. Data entered in micrososft excel, coded and analyzed using SPSS software version 25. Descriptive statistics for qualitative data were expressed as frequency and percentages and quantitative data as mean and standard deviation
Results: Out of 210 participants, 95.4% workers were suffering from one or the other morbidities. Arthralgia was the major concern followed by allergy, hypertension and thyroid. Prehypertensive state was found to be present among all participants. Anxiety noticed in majority of participants.
Conclusions: Frequent medical check-ups, recreational activities and health education sessions needs to be implemented in all cashew factories to lessen the morbidity and to up bring the health status of workers.
Coverage evaluation survey of COVID-19 vaccination among adolescents aged 12 to 17 years in the rural field practice area of medical college near Bangalore
Authors: Masthi N. R. Ramesh , C. S. Niveditha 
Published: June 2023

Background: COVID-19 vaccination in India was started from 16 January 2021. The vaccination for adolescents was started one year later. The only source of COVID-19 vaccination coverage is government data. There is a lack of external studies on COVID-19 vaccine coverage in this age group. In this regard, the present study was taken up with the objectives to assess the vaccination coverage of COVID-19 among adolescents aged 12-17 years and the factors associated with COVID-19 vaccine hesitancy.
Methods: A coverage evaluation survey was done for assessing COVID-19 vaccination coverage among adolescents aged 12 to 17 years from September to December 2022 in the rural field practice area of a medical college near Bangalore.
Results: Out of the 420 study subjects, 294 (70%) were fully vaccinated, 70 (16.6%) were partially vaccinated and 56 (13.4%) were unvaccinated. It was observed that the coverage of COVID-19 vaccine in the age group of 15 to 17 years was higher compared to 12 to 14 years.
Conclusions: The COVID 19 vaccine coverage with two doses among adolescents aged 12-14 was 61.9% and 78.1% among 210 adolescents aged 15 to 17 years in the rural locality. The most common reason for partial vaccination was that the school did not provide the second dose and the most common reason for not being vaccinated is that the subject was not eligible for vaccination during the school vaccination campaign.
Detection of polymyxin B resistance in Enterobacterales by broth disk elution method
Authors: Lal Aiswarya , Kumar K. S. Harish , Janardhanan Jiju , Gopal Anila 
Published: June 2023

Background: Antibiotic resistance being the critical issue faced by medical field, especially by Gram negative bacteria. It is a great threat in the case of both hospitals acquired and community acquired infections. They possess various mechanisms for their survival. The widespread resistance in Gram negative bacteria has necessitated evaluation of the use of older antimicrobials such as polymyxins. Polymyxins are disfavoured owing to their potential clinical toxicity, especially nephrotoxicity. Thus, they got abandoned in the sixties. But now they are re- emerged and used as last resort antibiotics.
Methods: 274 isolates of Enterobacterales including Klebsiella pneumoniae, Escherichia coli, Citrobacter spp. Enterobacter spp. was collected from various diagnostic microbiology laboratories in Kerala. The polymyxin resistance among Enterobacterales by broth disk elution method recommended by CLSI.
Results: In this study prevalence of multi drug resistant is 37% and extensively drug resistant strains is 25%. And the threatening fact is that the colistin also shows resistance among Enterobacterales (9.2%).
Conclusions: Though the resistance to Polymyxin B is to the lesser side in the present study, increase in resistance to the agent is being documented globally elsewhere. So, rational use of Polymyxin B is warrantied as we could cherish polymyxin B as a “life - saving drug” to avoid no drug available. Knowledge of antimicrobial resistance and development of new antimicrobial agents and improved treatments are essential in the current situation.
Anthropological commentary on COVID-19 vaccine hesitancy: a Bangladesh perspective
Authors: Chowdhury Shafquat H. , Mithila Turna T. , Tolchard Barry 
Published: June 2023

From a Bangladeshi perspective, this commentary discusses the problem of vaccine hesitancy (VH) and its outcome within the Bangladeshi population, including minority ethnic groups. Relatively low vaccination rates among the Bangladeshi population are associated with people's social and economic conditions and are the focus of public health activities and regulations in the broader region. This short commentary uses examples from minority ethnic groups in Bangladesh, including tribal groups, to address three main objectives. First, the need to understand better population management over vaccine outcomes and efforts to minimise overlooking the minority ethnic population. This understanding can assist in overcoming the reluctance of VH among the Bangladeshi people in a trusted and sustainable manner. Secondly, being part of a more comprehensive rethinking of public health interactions with minority ethnic populations, this commentary promotes exploring the epidemiological context of the VH rate among the Bangladeshi people. This paper proposes strengthening the credibility of vaccinations rather than recommending measures to encourage vaccine coverage in Bangladesh. Finally, it emphasises how crucial it is to interact with minority ethnic groups in the context of the new public health preparation strategies following Bangladeshi VH concepts. This article examines survey data and secondary information. PubMed and Google Scholar identified literature reviews to support the proof for exploring the possible concerns regarding VH among the Bangladeshi population.
A review of the treatment of drug induced presbyopia
Authors: Srivastava Namrata , Dwivedi P. N. , Chaurasia Vikas Kumar 
Published: June 2023

Presbyopia is characterized by accommodative loss that leads to negative effects on vision-targeted health-related quality of life. It occurs in people who gradually lose the ability to adapt after the age of 40. Accommodation depends on the contraction of the ciliary muscle and the iris, the change and the convergence of the lens. The parasympathetic nervous system regulates the degree of contraction of the ciliary muscle and the iris necessary to alter the shape and position of the lens, and its stimulation is effective by activating the muscarinic receptors present in both structures. The hypothesis presented here suggests that patients with emmetropic presbyopia correct accommodation with pharmacotherapy that includes a combination of cholinergic drugs and non-steroidal anti-inflammatory drugs (NSAIDs). Topical treatment deals with drug combinations to modify one or more factors involved in the accommodative process and have been proposed to be instilled either monocular/ binocularly. Result shows para-sympathomimetic stimulation of parasympathetic innervation (accommodation) and NSAID: Prolonging the effect of the para-sympathomimetic action and modulates the accommodation. The drug combination restores near vision without affecting distance vision. It is important to note that the drug form used has no inflammatory effects or other side effects. Despite the lack of a completely well understood mechanism, pharmacological control of presbyopia seems to be a possible and very attractive alternative for presbyopia patients. The studies mentioned in this review are to be considered pilot investigations as they involve either a small number of subjects or are single case series.
Comparative Analysis of Deep Learning Models for Dysarthric Speech Detection
Authors: Padmanaban Shanmugapriya , Mohan V 
Published: June 2023

Abstract
Dysarthria is a speech communication disorder that is associated with neurological impairments. In order to detect this disorder from speech, we present an experimental comparison of deep models developed based on frequency domain features. A comparative analysis of deep models is performed in the detection of dysarthria using scalogram of Dysarthric Speech. Also, it can assist physicians, specialists, and doctors based on the results of its detection. Since Dysarthric speech signals have segments of breathy and semi-whispery, experiments are performed only on the frequency domain representation of speech signals. Time domain speech signal is transformed into a 2-D scalogram image through wavelet transformation. Then, the scalogram images are applied to pre-trained convolutional neural networks. The layers of pre-trained networks are tuned for our scalogram images through transfer learning. The proposed method of applying the scalogram images as input to pre-trained CNNs is evaluated on the TORGO database and the classification performance of these networks is compared. In this work, AlexNet, GoogLeNet, and ResNet 50 are considered deep models of pre-trained convolutional neural networks. The proposed method of using pre-trained and transfer learned CNN with scalogram image feature achieved better accuracy when compared to other machine learning models in the dysarthria detection system.
Quality of Life of Children After Completion of Surgical Treatment for Anorectal Malformation: A Single-Centre Cross-Sectional Study in South-Western Uganda
Authors: Mucunguzi Denis , Oyania Felix , Egesa Walufu Ivan , Aturinde Mercy , Mutakooha Marvin Mwesigwa , Kyengera Kisitu Dan 
Published: June 2023

Abstract
Background
Anorectal malformations (ARMs) range from minor abnormalities such as imperforate anus to complex forms such as cloaca, and are often associated with other anomalies and residual functional stooling problems. The present study aimed to evaluate the quality of life (QoL) of children after surgical treatment for ARMs at Mbarara Regional Referral Hospital (MRRH) in South-Western Uganda.
Methods
In this cross-sectional study, we enrolled children who had completed surgical treatment for ARMs between 2014 to 2021 at MRRH. A 23-item PedsQL 4.0 inventory was used to evaluate health-related QoL in children using a multidimensional parent proxy reporting for children aged 3 months to 7 years and child self-reporting for children aged 8 to 17 years. Regression analysis was used to determine the association between sociodemographic and clinical variables and QoL. Crude and adjusted coefficients and their corresponding 95% confidence intervals (CI) were calculated. The significance level was set to a p-value < 0.05.
Results
A total of 88 participants (F:M ratio = 1.15:1) aged 3 months to 18 years with a median age of 4.5 (IQR 3–7) years were enrolled. The median age at diagnosis of ARM and preliminary diverting colostomy was 3 days (range: 2 to 30 days) and 3 days (range: 2 to 60 days) respectively. Rectovestibular fistulas, 47 (53.4%) were the most prevalent subtype of ARMs, and 5.7% of children had associated anomalies. Over one-third of the participants (38.6%) had definitive surgery after 3 years of age, and PSARP was the most common procedure. The average PedsQL score was 94 out of a maximum score of 100. The mean physical functioning score was 96.7 in males and 98.9 in females. The overall mean emotional functioning score was 91 ± 2. The mean social functioning score was 92 ± 3.0. The mean school functioning score was 95.7 in males and 98.5 in females. Associated anomalies and reoperation significantly predicted poor QoL. Increasing years after completion of surgery was significantly associated with good QoL scores.
Conclusion
The overall QoL of the participants was good. Associated anomalies and reoperation were associated with poor QoL, while years after completion of definitive surgery was associated with good QoL. There is need for increased awareness and utilization of QoL assessments as an outcome measure after definitive surgery for ARM.
Effect of Cinnamon and Aconite on Bone Formation-Bone Absorption Coupling in Bone Microenvironment
Authors: Yao Liping , Zhang Qiaoyan , Sun Peng , Qin Luping , Zhang Lu 
Published: June 2023

Abstract
Aconite and cinnamon can treat many diseases. The study aimed to assess the effectiveness and mechanism of aconite, cinnamon, and aconite-cinnamon in treating osteoporosis. The co-culture system was treated with serum containing aconite, cinnamon, and aconite-cinnamon, and the effects on osteoblast and osteoclast differentiation were evaluated through ALP activity, ALP staining, alizarin red staining, TRAP activity detection, TRAP staining, and F-actin staining. The study also examined the effects of aconite-cinnamon on intercellular factors using ELISA kits, and the effects on different genes were detected through RT-qPCR and Western blotting. Results showed that aconite-cinnamon improved osteoblast differentiation and activity, reduced the release of RANKL, inhibited osteoclast differentiation and activity, and activated the AMPK/SIRT1 signaling pathway in both osteoblasts and osteoclasts. Therefore, aconite-cinnamon can effectively treat and prevent osteoporosis by improving osteogenic differentiation activity and reducing osteoclast differentiation and activity, while activating the AMPK/SIRT1 signaling pathway in both osteoblasts and osteoclasts.
The predictive value of systemic nutritional and inflammatory biomarkers in patients with advanced gastrointestinal stromal tumor treated with imatinib
Authors: kus tulay , aktas gokmen , yucel hakan , safakoglu burhan 
Published: June 2023

Abstract
Background
Systemic nutritional and inflammatory biomarkers have been shown to be prognostic for many types of cancer. However, there are limited data on their predictive significance in advanced stage gastrointestinal stromal tumors (GISTs).
Methods
We retrospectively analyzed data of 71 patients with advanced GIST treated with first-line imatinib. A receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off value of nutritional and inflammatory parameters, including albumin-to-globulin ratio (AGR), prognostic-nutritional-index (PNI), systemic-immune-inflammation-index (SII), HALP (haemoglobin-albumin-lymphocyte-platelet), neutrophil/lymphocyte ratio (NLR), and haemoglobin for progression free survival (PFS). Kaplan-Meier curve was used to assess the predictive value of clinical and laboratory parameters, followed by multivariable analysis with cox-regression analysis.
Results
Median PFS was 26.0 (16.1–35.8) months. While age, gender, stage, metastatic site, number of metastases were not effective on PFS, HALP, PNI, haemoglobin, AGR and SII were predictive. In multivariate analysis, AGR (HR 95%CI: 2.01, 1.04–3.90, p value: 0.039) and Hgb (HR 95%CI: 2.22, 1.19–4.13, P: 0.012) remained independent predictive parameters for PFS. Age, HALP, Heamoglobin, and AGR were independent prognostic biomarkers for overall survival.
Conclusion
The predictive value of AGR and Hgb levels is more prominent in advanced stage GISTs than inflammatory parameters.
Fractional Amplitude of low frequency fluctuation changes in children with anisometropic amblyopia: a resting-state fMRI study
Authors: Yu Xueliang , Zhao Feng , Lu Weizhao , Chen Di , Li Xiujuan , Wang Yi , Wang Baojian 
Published: June 2023

Abstract
Aims: This study evaluates the changes of brain spontaneous activity in patients with anisometropia amblyopia compared with healthy controls.
Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data of 18 children patients with anisometropia amblyopia（PAA group）and 14 healthy children (control group) were collected. Fractional amplitude of low frequency fluctuation (fALFF) was used to assess brain spontaneous activity changes between the two groups. Two-sample t test was used for statistical analysis of fALFF value between groups. Pearson correlation was used to analyze the correlation between fALFF value in anisometropic amblyopia and clinical information.
Results: Compared with healthy controls, children with anisometropia amblyopia showed higher fALFF values in the middle right occipital gyrus and left central paracentric lobule. While fALFF value in the left middle frontal gyrus in children with anisometropic amblyopia was lower than that of healthy controls. There were no significant correlations between clinical information and mean fALFF values in PAA group.
Conclusion: Rs-fMRI fALFF analysis of children with anisometropic amblyopia reflects brain spontaneous activity changes in the visual cortex.
Microbial Community Structure and Metabolism of Xinjiang Fine-Wool Sheep based on high-throughput sequencing technology
Authors: Yao Rui , Dong Xuyang , Xu Yueren , Hu Ruirui , Wang Limin , Liu Xiaogang , Ni Wei , Zhou Ping , Hu Shengwei 
Published: June 2023

Abstract
Background: It turns out that the more than trillion microorganisms living in the host’s digestive tract are crucial for maintaining nutrient intake, environmental suitability, and physiological mechanism. Xinjiang Fine-Wool Sheep is a kind of wool breed bred independently in China, which excellent stress tolerance. Understanding the microbial community of Xinjiang Fine-Wool Sheep helps to raise sheep healthy and the production of superior traits.
Result: In this study, we collected feces and blood samples of 20 Xinjiang fine-wool sheep in different wool-length. By 16S rDNA amplicon sequence, ITS1 region amplicons and Targeted Metabolomics, we analysed the microbial community structure of fecal microorganisms and Short Chain Fatty Acids (SCFAs) in serum of the Xinjiang fine-wool sheep as different by the host wool-length. Fecal microbial sequencing showed that the bacterial composition and structure of the two groups were similar, while the fungal community composition and structure were significantly different. Among them, the bacterial gut community was similar to those characterised in previous studies and are the dominated phyla by Firmicutes and Bacteroidetes. However, compared to the Control Fine-Wool Sheep (CFWS) group, the fungal gut communities of Fine-Wool Sheep (FWS) have more abundant Neocallimastigomycota. According to report that polysaccharide degrading enzyme produced by a majority of the bacteria in Neocallimastigomycota can hydrolyze non-lignified plant cell walls. In addition, the results of serum SCFAs content showed that butyric acid were significantly differences than another group. Correlation analysis between SCFAs and bacteria found that butyric acid metabolism had positively correlated (p<0.05) with Ruminococcus and UCG-005.
Conclusion: Overall, our data provide more supplement about the gut microbes community composition and structure of the Xinjiang Fine-Wool Sheep. These results might be useful for improving stress tolerance and gut health in sheep, and taking nutritional control measure to improve production traits of animals in future.