bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonconvulsive status epilepticus in neurocritical care: A critical reappraisal of outcome prediction scores
Authors: Bögli Stefan Y. , Schmidt Tanja , Imbach Lukas L. , Nellessen Friederike , Brandi Giovanna 
Published: July 2023

AbstractObjectiveNonconvulsive status epilepticus (NCSE) is a frequent condition in the neurocritical care unit (NCCU) patient population, with high morbidity and mortality. We aimed to assess the validity of available outcome prediction scores for prognostication in an NCCU patient population in relation to their admission reason (NCSE vs. non‐NCSE related).MethodsAll 196 consecutive patients diagnosed with NCSE during the NCCU stay between January 2010 and December 2020 were included. Demographics, Simplified Acute Physiology Score II (SAPS II), NCSE characteristics, and in‐hospital and 3‐month outcome were extracted from the electronic charts. Status Epilepticus Severity Score (STESS), Epidemiology‐Based Mortality Score in Status Epilepticus (EMSE), and encephalitis, NCSE, diazepam resistance, imaging features, and tracheal intubation score (END‐IT) were evaluated as previously described. Univariable and multivariable analysis and comparison of sensitivity/specificity/positive and negative predictive values/accuracy were performed.ResultsA total of 30.1% died during the hospital stay, and 63.5% of survivors did not achieve favorable outcome at 3 months after onset of NCSE. Patients admitted primarily due to NCSE had longer NCSE duration and were more likely to be intubated at diagnosis. The receiver operating characteristic (ROC) for SAPS II, EMSE, and STESS when predicting mortality was between .683 and .762. The ROC for SAPS II, EMSE, STESS, and END‐IT when predicting 3‐month outcome was between .649 and .710. The accuracy in predicting mortality/outcome was low, when considering both proposed cutoffs and optimized cutoffs (estimated using the Youden Index) as well as when adjusting for admission reason.SignificanceThe scores EMSE, STESS, and END‐IT perform poorly when predicting outcome of patients with NCSE in an NCCU environment. They should be interpreted cautiously and only in conjunction with other clinical data in this particular patient group.
YKL‐40 immunoexpression as a prognosticator of mycosis fungoides
Authors: Neinaa Yomna Mazid El‐Hamd , Elsayed Hadeer Tarek Ismaiel , Alshenawy Hanan Alsaeid , Gamei Mohamed Mahmoud 
Published: July 2023

AbstractBackgroundYKL‐40 is a 40 kDa chitinase‐like glycoprotein that is predicted to contribute to the pathogenesis of several inflammatory and neoplastic conditions.ObjectivesTo assess YKL‐40 immunoexpression in different stages of mycosis fungoides (MF) to find out if YKL‐40 is playing a possible role in disease pathophysiology and progression.MethodsThis work included 50 patients with different stages of MF diagnosed on the basis of clinical, histopathological, and both CD4 and CD8 immunophenotyping, in addition to 25 normal control skin. The Immune Reactive Score (IRS) of YKL‐40 expression was determined in all specimens and statistically analyzed.ResultsYKL‐40 expression reported a significant rise in MF lesions compared to control skin. Among MF specimens, the mildest expression was observed in the early patch stage followed by the plaque stage, while the strongest was in tumor stages. Positive correlations were discovered between IRS of YKL‐40 expression in MF specimens and patients' age, disease chronicity, clinical staging, and TNMB classification.ConclusionYKL‐40 might participate in MF pathophysiology, and the highest expression is associated with advanced stages of the disease and poor outcomes. Therefore, it might be of value as a prognosticator for monitoring high‐risk MF patients and follow‐up assessment of treatment success.
Colour properties and tannin concentrations of polymeric phenolic materials extracted from Pinot Noir wines of a single NZ producer
Authors: Zhao Meijing , Harrison Roland , Frost Andrew , Tian Bin 
Published: July 2023

SummaryPolymeric phenolic material (PPM) was separated from monomeric anthocyanins by removing the latter using isoamyl alcohol in 22 Pinot Noir wines of different vintages and grades. The colour and tannin concentrations of PPM were determined using a modified Somers assay and methylcellulose precipitation (MCP) tannin assay, respectively. With wine age increasing, the ratio of absorbance at 520 nm at pH 1.0 to that at 3.4 decreased from 2.6 to 1.1. This decreasing trend with wine age is reported for the first time in Pinot Noir wines. The presence of bleachable polymeric pigments was also observed in PPM, and the degree of ionisation of these bleachable pigments increased along with wine age. Statistical analysis demonstrated the dominant effect of age on colour properties of PPM, regardless of vintage and grade. In contrast, total phenolics and tannin concentration mainly related to vintage, rather than age.
RETRACTED: Association between malnutrition and surgical site wound infection among spinal surgery patients: A meta‐analysis
Authors: Xie Jiang , Du Yuxuan , Tan Zejiu , Tang Hao 
Published: July 2023

AbstractA surgical site infection (SSI) is one of the most common complications of spinal surgery. Malnutrition has also been linked to SSI after other surgical procedures. However, whether malnutrition is a risk factor for SSI after spinal surgery remains controversial. Therefore, we performed a meta‐analysis to comprehensively evaluate the relationship between malnutrition and SSI. Relevant studies of the correlation between malnutrition and SSI were retrieved from the Cochrane Library, EMBASE, PubMed, Web of Science, China National Knowledge Infrastructure and Wanfang Data from database inception to 21 May 2023. Two reviewers independently assessed the included studies, and a meta‐analysis was performed using STATA 17.0 software. A total of 24 articles with 179 388 patients were included: 3919 and 175 469 cases comprised the SSI and control groups, respectively. The meta‐analysis results showed that malnutrition significantly increased the SSI incidence (odds ratio, 1.811; 95% confidence interval, 1.512–2.111; p < 0.001). These results suggest that patients with malnutrition are at higher risk for SSI after surgery. However, because of significant differences in sample sizes among studies, and because some studies had limitations to their methodological quality, further validation of these results by additional high‐quality studies with larger sample sizes is necessary.
Parents' perspectives on reasonable adjustments in acute healthcare for people with intellectual disability: A qualitative descriptive study
Authors: Moloney Mairead , Hennessy Therese , Doody Owen 
Published: July 2023

AbstractAimTo describe parents' perspectives on reasonable adjustments in acute healthcare for people with intellectual disability (ID).BackgroundPeople with ID are vulnerable in terms of their health needs and marginalized when accessing and utilizing acute healthcare services. Reasonable adjustments are positive measures that can help alleviate health disparities. However, despite significant research advocating their use, evidence of implementation of reasonable adjustments in acute healthcare practice is limited.DesignA qualitative descriptive study.MethodsQualitative semi‐structured interviews were conducted with six parents of children with ID, who had accessed and used acute healthcare services. The interviews were conducted between January and May 2022, audio‐recordings were transcribed and thematically analysed.ResultsParents described limited or no experiences of reasonable adjustments when accessing or utilizing acute healthcare services for their children. The findings are captured in three themes; describing the reality, understanding the impact and signposting the future. The findings highlight a lack of implementation of reasonable adjustments in acute healthcare which negatively impacts the experience of all stakeholders.ConclusionThere is a pressing need for reasonable adjustments to be implemented at a strategic level across acute healthcare services, so that people with ID and their families can access person‐centred acute healthcare when needed.ImpactThe research findings will inform researchers interested in reasonable adjustments and implementation research, and those interested in advocating for the rights of people with ID.Reporting MethodThis study adhered to the Equator research reporting checklist: Consolidated criteria for reporting qualitative research: a 32‐item checklist for interviews and focus groups.Patient or Public ContributionA parent of a child with an ID was part of the research team informing the design, data collection, data analysis and write‐up of this article.
Processing of cooked marinated chicken breast: Evaluation of the final product and wastewater
Authors: da Silva Heloísa Righi Pessoa , Batistela Vagner Roberto , Porciuncula Barbara Daniele Almeida , Barros Beatriz Cervejeira Bolanho 
Published: July 2023

AbstractThis study aimed to investigate the process of marination of chicken breast, assess the characteristics of the final product (cooked and diced) and determine wastewater generation and composition. Breast fillet samples were marinated, and tumbled at 4 rpm and 540 mmHg for 60 min. Different formulations were prepared by varying the brine (20.15%–9.15% w/w) to chicken breast (79.85%–90.85% w/w) ratio. Wastewater generation decreased from 82.95 to 10.67 m3 t−1 by reducing the proportion of brine used in formulations. Moisture content, protein content, and hardness of final products ranged from 68.97 to 70.43 g 100 g−1, 61.63 to 64.55 g 100 g−1, and 22.52 to 30.06 N, respectively. The standard formulation and that prepared with the lowest brine proportion had similar sensory attributes, indicating that brine reduction is a viable strategy to decrease the volume and organic load of the resulting wastewater, increasing the sustainability of the agroindustrial chain.Practical ApplicationsThe definition of the conditions of tumbling, together with the choice of the best proportion of chicken breast fillet and brine used in the marination of chicken breast fillet, promote the reduction of the volume of wastewater generated by the industry, and, increases its degradability. Moreover, the final product (chicken breast diced and cooked) obtained in the modified process have physical–chemical and sensory properties similar to the conventional product.
Clinical characteristics of absent contractility and ineffective esophageal motility: a multicenter study in Japan
Authors: Ikebuchi Yuichiro , Sato Hiroki , Ikeda Haruo , Abe Hirofumi , Ominami Masaki , Shiota Junya , Sato Chiaki , Fukuda Hisashi , Ogawa Ryo , Tatsuta Tetsuya , Yokomichi Hiroshi , Isomoto Hajime , Inoue Haruhiro 
Published: July 2023

AbstractBackground and AimAbsent contractility (AC) and ineffective esophageal motility (IEM) are esophageal hypomotility disorders diagnosed using high‐resolution manometry (HRM). Patient characteristics and disease course of these conditions and differential diagnosis between AC and achalasia are yet to be elucidated.MethodsA multicenter study involving 10 high‐volume hospitals was conducted. Starlet HRM findings were compared between AC and achalasia. Patient characteristics including underlying disorders and disease courses were analyzed in AC and IEM.ResultsFifty‐three patients with AC and 92 with IEM were diagnosed, while achalasia was diagnosed in 1784 patients using the Chicago classification v3.0 (CCv3.0). The cut‐off integrated relaxation pressure (IRP) value at 15.7 mmHg showed maximum sensitivity (0.80) and specificity (0.87) for differential diagnosis of AC from type I achalasia. While most ACs were based on systemic disorders such as scleroderma (34%) and neuromuscular diseases (8%), 23% were sporadic cases. The symptom severity of AC was not higher than that of IEM. Regarding the diagnosis of IEM, the more stringent CCv4.0 excluded 14.1% of IEM patients than the CCv3.0, although patient characteristics did not change. In patients with the hypomotile esophagus, concomitance of reflux esophagitis was associated with low distal contractile integral and IRP values. AC and IEM transferred between each other, paralleling with the underlying disease course, although no transition to achalasia was observed.ConclusionA successful determination of the optimal cut‐off IRP value was achieved using the starlet HRM system to differentiate AC and achalasia. Follow‐up HRM is also useful for differentiating AC from achalasia. Symptom severity may depend on underlying diseases instead of hypomotility severity.
Investigating the interfaces of the epiphyseal plate: An integrated approach of histochemistry, microtomography and SEM
Authors: Zecca Piero Antonio , Reguzzoni Marcella , Borgese Marina , Protasoni Marina , Filibian Marta , Raspanti Mario 
Published: July 2023

AbstractWe investigated the interfaces of the epiphyseal plate with over‐ and underlying bone segments using an integrated approach of histochemistry, microtomography and scanning electron microscopy (SEM) to overcome the inherent limitations of sections‐based techniques. Microtomography was able to provide an unobstructed, frontal view of large expanses of the two bone surfaces facing the growth plate, while SEM observation after removal of the soft matrix granted an equally unhindered access with a higher resolution. The two interfaces appeared widely dissimilar. On the diaphyseal side the hypertrophic chondrocytes were arranged in tall columns packed in a sort of compact palisade; the interposed extracellular matrix was actively calcifying into a thick mineralized crust growing towards the epiphysis. Behind the mineralization front, histochemical data revealed a number of surviving cartilage islets which were being slowly remodelled into bone. In contrast, the epiphyseal side of the cartilage consisted of a relatively quiescent reserve zone whose mineralization was marginal in amount and discontinuous in extension; the epiphyseal bone consisted of a loose trabecular meshwork, with ample vascular spaces opening directly into the non‐mineralized cartilage. On both sides the calcification process took place through the formation of spheroidal bodies 1–2 μm wide which gradually grew by apposition and coalesced into a solid mass, in a way distinctly different from that of bone and other calcified tissues.
Reconstructed magnetic resonance image‐based effusion volume assessment for temporomandibular joint arthralgia
Authors: Xu Jiali , Wang Dongmei , Yang Chunhua , Wang Fangfang , Wang Meiqing 
Published: July 2023

AbstractBackgroundJoint effusion is often noticed in magnetic resonance image (MRI) and its diagnostic value for arthralgia of the temporomandibular joint (TMJ) remains obscure.ObjectiveTo develop a method for quantitatively evaluating the joint effusion revealed in MRI and its diagnostic value for arthralgia of the TMJ.MethodsTwo‐hundreds and twenty‐eight TMJs, 101 with arthralgia (Group P) and 105 without (Group NP) from 103 patients, and 22 TMJs (Group CON) from 11 asymptomatic volunteers were examined by using MRI. The effusion volume was measured after constructing a three‐dimensional structure of the joint effusion revealed in MRI by using the ITK‐SNAP software. The diagnostic capabilities of the effusion volume on arthralgia were evaluated with receiver operating characteristic (ROC) curve analysis.ResultsTotally 146 joints showed MRI signs of joint effusion, including nine joints from Group CON. However, the medium volume was greater in Group P (66.65 mm3), but was much similar in Group CON (18.33 mm3) to Group NP (27.12 mm3). The effusion volume larger than 38.20 mm3 was validated to discriminate Group P from Group NP. The AUC value was 0.801 (95% CI 0.728 to 0.874), with a sensitivity of 75% and specificity of 78.9%. The median volume of the joint effusion was larger in those with than without bone marrow oedema, osteoarthritis, Type‐III disc configurations, disc displacement and higher signal intensity of the retrodiscal tissue (all, p < .05).ConclusionThe present method for evaluate joint effusion volume well discriminated painful TMJs from non‐pain ones.
Disruption of serotonin biosynthesis increases resistance to striped stem borer without changing innate defense response in rice
Authors: Wang Long , Lu Haiping , Zhang Xiaoyan , He Yuxin , Zhang Jiarun , Guo Xiaohao , Fu Haowei , Ye Gongyin , Shu Qingyao 
Published: July 2023

AbstractStriped stem borer (SSB) is one of the most damaging pests in rice production worldwide. Previously, we preliminarily demonstrated that indica rice Jiazhe LM, an OsT5H (encoding tryptamine‐5‐hydroxylase) knockout mutant deficient in serotonin, had increased resistance to SSB as compared with its wildtype parent Jiazhe B. However, the full scenario of SSB resistance and the underlying mechanism remain unknown. In this study, we first demonstrated that the OsT5H knockout could generally increase rice resistance to SSB and then proved that the OsT5H knockout does not disrupt the innate defense response of rice plants to SSB infestation, that is, OsT5H knockout mutations neither had significant effect on the transcriptional response of defense genes upon SSB infestation, nor the profile of defense related metabolites and plant hormones, such as lignin, salicylic acid, jasmonic acid, and abscisic acid, nor the activity of reactive oxygen species (ROS) scavenging enzymes and the ROS contents. We then demonstrated that supplementation of serotonin promoted SSB growth and performance in artificial diet feeding experiments. We observed that SSB larvae feeding on Jiazhe B had serotonin 1.72‐ to 2.30‐fold that of those feeding on Jiazhe LM at the whole body level, and more than 3.31 and 1.84 times in the hemolymph and head, respectively. Further studies showed that the expression of genes involved in serotonin biosynthesis and transport was ~88.1% greater in SSB larvae feeding on Jiahze LM than those feeding on Jiazhe B. These observations indicated that SSB increases serotonin synthesis when feeding on serotonin deficient rice but is unable to fully compensate the dietary serotonin deficiency. Put together, the present study strongly suggests that it is the deficiency of serotonin, not the secondary effect of OsT5H knockout on innate defense response confers the SSB resistance in rice, which implies that reducing serotonin level, particularly through inhibition of its inductive synthesis upon SSB damage, could be an efficient strategy for breeding SSB resistant varieties.
Amelioration of gamma irradiation‐induced salivary gland damage in mice using melatonin
Authors: Ren Jingming , Zhu Tong , Wang Zhouxuan , Lu Lu , Fan Saijun 
Published: July 2023

AbstractSalivary gland damage caused by ionizing radiation (IR) severely affects the patient quality of life and influences the efficacy of radiotherapy. Most current treatment modalities are palliative, so effective prevention of damage caused by IR is essential. Melatonin (MLT) is an antioxidant that has been reported to prevent IR‐induced damage in a range of systems, including the hematopoietic system and gastrointestinal tract. In this study, we explored the effects of MLT on whole‐neck irradiation (WNI)‐induced salivary gland damage in mice. The results revealed that by protecting the channel protein AQP‐5, MLT not only alleviates salivary gland dysfunction and maintains salivary flow rate, but also protects salivary gland structure and inhibits the WNI‐induced reduction in mucin production and degree of fibrosis. Compared with WNI‐treated mice, in those receiving MLT, we observed a modulation of oxidative stress in salivary glands via its effects on 8‐OHdG and SOD2, as well as an inhibition of DNA damage and apoptosis. With respect to its radioprotective mechanism, we found that MLT may alleviate WNI‐induced xerostomia partly by regulating RPL18A. In vitro, we demonstrated that MLT has radioprotective effects on salivary gland stem cells (SGSCs). In conclusion, our data this study indicate that MLT can effectively alleviate radiation‐induced damage in salivary glands, thereby providing a new candidate for the prevention of WNI‐induced xerostomia.
In ovo injection of soy isoflavones on hatching performance and intestinal development of newly hatched chicks
Authors: Abdelghani Ezaldeen , Fathi Mohamed A. , Li Zhaojian , Dai Pengyuan , Li Yansen , Li Chunmei 
Published: July 2023

AbstractThis study aimed to evaluate the effects of in ovo injection of soy isoflavones (ISF) on hatchability, body weight, antioxidant status and intestinal development of newly hatched broiler chicks. One hundred and eighty fertile eggs were divided as follows: the control group, 3 mg/egg ISF (low dose) and 6 mg/egg ISF (high dose) on the 18th day of incubation. The results demonstrated that in ovo inclusion of 6 mg of ISF significantly increased hatchability and hatch weight. Both doses of ISF inclusion elevated the serum glutathione peroxidase and slightly decreased malondialdehyde compared to the control group. The high dose of ISF brings higher villus height and a higher villus/crypt ratio in chicks. Moreover, the mRNA levels of tumour necrosis factor‐ α and interferon‐gamma in the spleen were significantly decreased. The ISF treatments showed an improvement in intestinal enzyme expression levels of sucrose isomaltase and mucin 2 as well as tight junction protein (TJ) mRNA expression of claudin‐1 at high doses of ISF (p < 0.05) when compared with the other groups. Furthermore, the mRNA level of IGF‐1 was increased in the high doses of ISF compared to the control. Overall, these findings indicate that in ovo administration of ISF on the 18th day of incubation enhances hatchability, antioxidant status and intestinal morphometrics in hatched chicks and modulates the expression of proinflammatory cytokines, TJs and insulin‐like growth factor. In addition, the sustainability of antioxidants and other positive effects of ISF may increase chick viability and growth performance.
I through thou, and we through I: Dietrich von Hildebrand and Karol Wojtyla on the personal foundation of community
Authors: Matiashvili Lasha 
Published: July 2023

AbstractThis article is an attempt to scrutinize the phenomenological social ontology of Dietrich von Hildebrand and Karol Wojtyla by drawing on the particular role and nature of interpersonal relatedness and second‐person engagement in the constitution of first‐person‐plural perspective. Both Hildebrand and Wojtyla endorse the unique value of the person and personality as the foundational principle for different dimensions of community, including the face‐to‐face “I‐thou” way of being together and more complex, even anonymous, we communities. Both philosophers deny the constitutive primacy of first‐person plural over first‐person singular, the only exception being the mystical body of Christ when “I” is conditioned and formed by “we.” Moreover, what they have in common is the critical reappraisal of one stream in the phenomenological movement, first and foremost associated with Max Scheler's conception of the possibility of a “collective person.” Drawing on Hildebrand's and Wojtyla's accounts, the article endorses the view regarding the relational character of “I,” “thou,” and “we,” claiming that “we” hinges on an experiential dimension of “I.”