bluuebunny/crossref_metadata_2025_split huggingface dataset:
Octahedron distortion-triggered dipole–spin interaction in multiferroic magnetoelectric perovskites
Authors: Lu Xiangqian , Hu Renjie , Zhu Yabin , Song Kepeng , Qin Wei 
Published: June 2023

AbstractThe design of perovskite structures with multiferroic magnetoelectric coupling effects opens up new opportunities in fields such as the creation of next-generation spin-dependent multistate information storage technologies. In this work, we prepared a transition metal-implanted perovskite with multiferroic magnetoelectric coupling, in which both magnetoelectric coupling and a blueshift of photoluminescence were observed. The introduction of transition metal-generated polarized spin interacts with the electronic orbit through spin–orbital coupling to lead to a pronounced octahedron distortion, where the temperature dependence of the dielectric constant undergoes a ferroelectric polarization transition. An external magnetic field could enhance the strength of spin polarization to further affect the magnitude of electric polarization. Moreover, applying an electric field tunes the distortion of the octahedron dependence of electric polarization to feed back to the change in spin polarization. Overall, the spin polarization-induced electric polarization in perovskites provides a unique approach to realizing the room-temperature magnetoelectric coupling of multiferroic materials.
Single cell transcriptomics identifies distinct profiles in pediatric acute respiratory distress syndrome
Authors: Flerlage Tim , Crawford Jeremy Chase , Allen E. Kaitlynn , Severns Danielle , Tan Shaoyuan , Surman Sherri , Ridout Granger , Novak Tanya , Randolph Adrienne , West Alina N. , Thomas Paul G. 
Published: June 2023

AbstractAcute respiratory distress syndrome (ARDS), termed pediatric ARDS (pARDS) in children, is a severe form of acute respiratory failure (ARF). Pathologic immune responses are implicated in pARDS pathogenesis. Here, we present a description of microbial sequencing and single cell gene expression in tracheal aspirates (TAs) obtained longitudinally from infants with ARF. We show reduced interferon stimulated gene (ISG) expression, altered mononuclear phagocyte (MNP) transcriptional programs, and progressive airway neutrophilia associated with unique transcriptional profiles in patients with moderate to severe pARDS compared to those with no or mild pARDS. We additionally show that an innate immune cell product, Folate Receptor 3 (FOLR3), is enriched in moderate or severe pARDS. Our findings demonstrate distinct inflammatory responses in pARDS that are dependent upon etiology and severity and specifically implicate reduced ISG expression, altered macrophage repair-associated transcriptional programs, and accumulation of aged neutrophils in the pathogenesis of moderate to severe pARDS caused by RSV.
Ultrasound-responsive low-dose doxorubicin liposomes trigger mitochondrial DNA release and activate cGAS-STING-mediated antitumour immunity
Authors: Wang Chaoyu , Zhang Ruoshi , He Jia , Yu Lvshan , Li Xinyan , Zhang Junxia , Li Sai , Zhang Conggang , Kagan Jonathan C. , Karp Jeffrey M. , Kuai Rui 
Published: June 2023

AbstractDNA derived from chemotherapeutics-killed tumor cells is one of the most important damage-associated molecular patterns that can activate the cGAS-STING (cyclic GMP-AMP synthase—stimulator of interferon genes) pathway in antigen-presenting cells (APCs) and promote antitumor immunity. However, conventional chemotherapy displays limited tumor cell killing and ineffective transfer of stable tumor DNA to APCs. Here we show that liposomes loaded with an optimized ratio of indocyanine green and doxorubicin, denoted as LID, efficiently generate reactive oxygen species upon exposure to ultrasound. LID plus ultrasound enhance the nuclear delivery of doxorubicin, induce tumor mitochondrial DNA oxidation, and promote oxidized tumor mitochondrial DNA transfer to APCs for effective activation of cGAS-STING signaling. Depleting tumor mitochondrial DNA or knocking out STING in APCs compromises the activation of APCs. Furthermore, systemic injection of LID plus ultrasound over the tumor lead to targeted cytotoxicity and STING activation, eliciting potent antitumor T cell immunity, which upon the combination with immune checkpoint blockade leads to regression of bilateral MC38, CT26, and orthotopic 4T1 tumors in female mice. Our study sheds light on the importance of oxidized tumor mitochondrial DNA in STING-mediated antitumor immunity and may inspire the development of more effective strategies for cancer immunotherapy.
Advanced characterization-informed machine learning framework and quantitative insight to irradiated annular U-10Zr metallic fuels
Authors: Xu Fei , Cai Lu , Salvato Daniele , Dilemma Fidelma , Capriotti Luca , Yao Tiankai 
Published: June 2023

AbstractU-10Zr Metal fuel is a promising nuclear fuel candidate for next-generation sodium-cooled fast spectrum reactors. Since the Experimental Breeder Reactor-II in the late 1960s, researchers accumulated a considerable amount of experience and knowledge on fuel performance at the engineering scale. However, a mechanistic understanding of fuel microstructure evolution and property degradation during in-reactor irradiation is still missing due to a lack of appropriate tools for rapid fuel microstructure assessment and property prediction based on post irradiation examination. This paper proposed a machine learning enabled workflow, coupled with domain knowledge and large dataset collected from advanced post-irradiation examination microscopies, to provide rapid and quantified assessments of the microstructure in two reactor irradiated prototypical annular metal fuels. Specifically, this paper revealed the distribution of Zr-bearing secondary phases and constitutional redistribution across different radial locations. Additionally, the ratios of seven different microstructures at various locations along the temperature gradient were quantified. Moreover, the distributions of fission gas pores on two types of U-10Zr annular fuels were quantitatively compared.
Three fourths of women of reproductive age in emerging regions of Ethiopia are facing problems in accessing health care
Authors: Fetene Samrawit Mihret , Haile Tsegaye Gebremedhin 
Published: June 2023

AbstractProviding adequate and equal access health care is a key goal towards universal health coverage (UHC), but women continue to confront considerable inequities in accessing healthcare, particularly in the emerging regions of Ethiopia. Therefore, we identified the contributing factors to the problems in accessing health care among women of reproductive age in emerging regions of Ethiopia. Data from the 2016 Ethiopia Demographic and Health Survey were used. A total of 4680 women in reproductive age were included in the final analysis and a multilevel mixed-effect binary logistic regression analysis was done to identify the contributing factors to the problems in accessing health care. In the final model, a p-value of less than 0.05 and adjusted odds ratio (AOR) with 95% confidence interval (CI) were used to declare statistically significant factors. We found that 71.0% (95% CI 69.64–72.24%) of women in reproductive age had problems in accessing health care. Unmarried women (AOR = 1.30 95% CI 1.06–1.59), uneducated (AOR = 2.21 95% CI 1.48–3.30) and attended primary school (AOR = 1.58 95% 1.07–2.32), rural resident (AOR = 2.16 95% CI 1.40–2.02), poor (AOR = 2.95 95% CI 2.25–3.86) and middle wealth status (AOR = 1.74 95% CI 1.27–2.40), women who gave two births (AOR = 1.29 95% CI: 1.02–1.64) and not working (AOR = 1.33 95% CI 1.06, − 1.68) and working in agriculture (AOR = 1.88 95% CI 1.35–2.61) were factors that contributed for the problems in accessing health care. A significant proportion of women of reproductive age in emerging regions of Ethiopia face challenges in accessing healthcare, which places the country far from achieving its UHC targets. This issue is particularly prominent among unmarried, poor and middle wealth status, uneducated, non-working, and rural women of reproductive age. The government should develop strategies to improve women’s education, household wealth status, and occupational opportunities which would help to alleviate the barriers hindering healthcare access for women residing in emerging regions of Ethiopia.
White matter hyperintensities associated with impulse control disorders in Parkinson’s Disease
Authors: Hernadi Gabriella , Perlaki Gabor , Kovacs Marton , Pinter David , Orsi Gergely , Janszky Jozsef , Kovacs Norbert 
Published: June 2023

AbstractImpulse control disorders (ICDs) in Parkinson's disease (PD) are increasingly recognized as clinically significant non-motor features that potentially impair the quality of life. White matter hyperintensities (WMHs), detected by magnetic resonance imaging, are frequently observed in PD and can be associated with both motor- and certain non-motor symptoms. Given the limited number of non-motor features studied in this context, our aim was to reveal the potential association between the severity of WMHs and ICDs in PD. Fluid-attenuated inversion recovery magnetic resonance images were retrospectively evaluated in 70 patients with PD (48 males; 59.3 ± 10.1 years). The severity of WMHs was assessed by Fazekas scores and by the volume and number of supratentorial WMHs. ICDs were evaluated using the modified Minnesota Impulsive Disorders Interview. Significant interaction between age and the severity of WMHs was present for ICDs. In our younger patients (< 60.5 years), severity of WMHs was positively associated with ICDs (p = 0.004, p = 0.021, p < 0.001 and p < 0.001, respectively for periventricular white matter and total Fazekas scores and the volume and number of WMHs). Our study supports the hypothesis that WMHs of presumed vascular origin may contribute to ICDs in PD. Future prospective studies are needed to assess the prognostic relevance of this finding.
Effect of leisure-time physical activity on blood pressure in people with hypertension: a systematic review and meta-analysis
Authors: Shariful Islam Md , Fardousi Ammatul , Sizear Monaemul Islam , Rabbani Md. Golam , Islam Rubana , Saif-Ur-Rahman K. M. 
Published: June 2023

AbstractHigh blood pressure is a major risk factor for premature death. Leisure-time physical activities have been recommended to control hypertension. Studies examining how leisure-time physical activity affects blood pressure have found mixed results. We aimed to conduct a systematic review examining the effect of leisure-time physical activity (LTPA) on lowering blood pressure among adults living with hypertension. We searched studies in Embase, Medline/PubMed, Web of Science, Physical Education Index, Scopus and CENTRAL (the Cochrane Library). The primary outcome variables were systolic blood pressure (SBP) and diastolic blood pressure (DBP). This systematic review is registered on PROSPERO (CRD42021260751). We included 17 studies out of 12,046 screened articles in this review. Moderate-intensity LTPA (all types) reduced SBP compared to the non-intervention control group (MD −5.35 mm Hg, 95% CI −8.06 to −2.65, nine trials, n = 531, low certainty of the evidence). Mean DBP was reduced by −4.76 mm Hg (95% CI −8.35 to −1.17, nine trials, n = 531, low certainty of the evidence) in all types of LTPA (moderate intensity) group compared to the non-intervention control group. Leisure-time walking reduced mean SBP by −8.36 mmHg, 95% CI −13.39 to −3.32, three trials, n = 128, low certainty of the evidence). Walking during leisure time reduced −5.03 mmHg mean DBP, 95% CI −8.23 to −1.84, three trials, n = 128, low certainty of the evidence). Performing physical activity during free time probably reduces SBP and DBP (low certainty of the evidence) among adults with hypertension.
Foraging for selenium: a comparison between hyperaccumulator and non-accumulator plant species
Authors: Montanari Sofia , Salinitro Mirko , Simoni Andrea , Ciavatta Claudio , Tassoni Annalisa 
Published: June 2023

AbstractSelenium (Se) hyperaccumulators are a unique group of plants that can accumulate this element in their aerial parts at concentrations exceeding 100 mg kgDW−1. These plants actively search for Se in the soil, a phenomenon known as root foraging, reported to date only by few studies. In this study, the effect of localized Se enrichment, in the form of selenite and selenate, was investigated on the root architecture of two Se-hyperaccumulators (Stanleya pinnata and Astragalus bisulcatus) and two non-accumulators (Brassica juncea and Medicago sativa). Rhizoboxes were divided into two halves: one half was filled with control soil while the other with selenate or selenite (30 mg kgDW−1) spiked soil. Seedling were transferred into the interface of the two soils and allowed to grow for three weeks under controlled light and temperature conditions. Staneya pinnata exhibited equal root density in both halves of the rhizobox when grown in control/control and selenite/control soil treatments. However, in the presence of selenate, S. pinnata developed 76% of the roots towards the selenate-enriched half, indicating an active root foraging. In contrast, A. bisulcatus and the non-accumulators B. juncea and M. sativa did not show any preferential distribution of roots. This study revealed that only S. pinnata showed the ability to detect and forage for Se when provided as selenate. Non-accumulators did not show any morphological or Se-accumulation difference associated with the presence of Se in soil in either form.
Understanding voltage-controlled magnetic anisotropy effect at Co/oxide interface
Authors: Nozaki Tomohiro , Okabayashi Jun , Tamaru Shingo , Konoto Makoto , Nozaki Takayuki , Yuasa Shinji 
Published: June 2023

AbstractThe voltage-controlled magnetic anisotropy (VCMA) effect is a key to realising high-speed, ultralow-power consumption spintronic devices. The fcc-Co-(111)-based stack is a promising candidate for the achievement of large VCMA coefficients. However, only a few studies on the fcc-Co-(111)-based stack have been reported and the VCMA effect has not been well understood. Previously, we observed a significant increase in the voltage-controlled coercivity (VCC) in the Pt/Ru/Co/CoO/TiOx structure upon post-annealing. However, the mechanism underlying this enhancement remains unclear. This study performs multiprobe analyses on this structure before and after post-annealing and discusses the origin of the VCMA effect at the Co/oxide interface. X-ray magnetic circular dichroism measurement revealed an increase in the orbital magnetic moment owing to post-annealing, accompanied by a significant increase in VCC. We speculate that the diffusion of Pt atoms into the vicinity of Co/oxide interface enhances the interfacial orbital magnetic moment and the VCMA at the interface. These results provide a guideline for designing structures to obtain a large VCMA effect in fcc-Co-(111)-based stacks.
Green solvent mediated extraction of micro- and nano-plastic particles from water
Authors: Hunter Jameson R. , Qiao Qi , Zhang Yuxuan , Shao Qing , Crofcheck Czarena , Shi Jian 
Published: June 2023

AbstractThe production of plastic and the amount of waste plastic that enters the ecosystem increases every year. Synthetic plastics gradually break down into particles on the micro- and nano-scale in the environment. The micro- and nano-plastics pose a significant ecological threat by transporting toxic chemicals and causing inflammation and cellular damage when ingested; however, removal of those particles from water is challenging using conventional separation methods. Deep eutectic solvents (DES), a new class of solvents composed of hydrogen bond donors and acceptors, have been proposed as a cheaper alternative to ionic liquids. Hydrophobic DES derived from natural compounds (NADES) show promise as extractants in liquid–liquid extractions. This study investigated the extraction efficiency of micro- and nano-plastics including polyethylene terephthalate, polystyrene, and a bioplastic polylactic acid from fresh water and saltwater using three hydrophobic NADES. The extraction efficiencies fall in a range of 50–93% (maximum % extraction) while the extraction rates fall between 0.2 and 1.3 h (as indicated by the time to extract half the theoretical maximum). Molecular simulations show a correlation between the extraction efficiency and the association between the plastics and NADES molecules. This study demonstrates the potential of hydrophobic NADES as extractants for removal of different micro- and nano-plastic particles from aqueous solutions.
Small RNA sequencing of field Culex mosquitoes identifies patterns of viral infection and the mosquito immune response
Authors: Abel Steven M. , Hong Zhenchen , Williams Desiree , Ireri Sally , Brown Michelle Q. , Su Tianyun , Hung Kim Y. , Henke Jennifer A. , Barton John P. , Le Roch Karine G. 
Published: June 2023

AbstractMosquito-borne disease remains a significant burden on global health. In the United States, the major threat posed by mosquitoes is transmission of arboviruses, including West Nile virus by mosquitoes of the Culex genus. Virus metagenomic analysis of mosquito small RNA using deep sequencing and advanced bioinformatic tools enables the rapid detection of viruses and other infecting organisms, both pathogenic and non-pathogenic to humans, without any precedent knowledge. In this study, we sequenced small RNA samples from over 60 pools of Culex mosquitoes from two major areas of Southern California from 2017 to 2019 to elucidate the virome and immune responses of Culex. Our results demonstrated that small RNAs not only allowed the detection of viruses but also revealed distinct patterns of viral infection based on location, Culex species, and time. We also identified miRNAs that are most likely involved in Culex immune responses to viruses and Wolbachia bacteria, and show the utility of using small RNA to detect antiviral immune pathways including piRNAs against some pathogens. Collectively, these findings show that deep sequencing of small RNA can be used for virus discovery and surveillance. One could also conceive that such work could be accomplished in various locations across the world and over time to better understand patterns of mosquito infection and immune response to many vector-borne diseases in field samples.
Fluorescence intensity and fluorescence lifetime measurements of various carbon dots as a function of pH
Authors: Szapoczka Wiktoria K. , Truskewycz Adam L. , Skodvin Tore , Holst Bodil , Thomas Peter J. 
Published: June 2023

AbstractMeasurement and monitoring of pH are essential in both the industry and academia. It is therefore important to continue developing novel, low-cost pH sensors that provide increased accuracy over long periods of time. Particularly promising are sensors based on materials that show pH-dependent fluorescence intensity (FI) and lifetime (FL). Carbon dots (CDs) are emerging as promising candidates because of their low cost, ease of manufacturing, low toxicity, and negligible photobleaching. However, little has been done to quantify the FI and FL values of CDs. Here we report the characterisation of the pH-dependent FI and FL of four novel solvothermal synthesised CDs. The fifth CD is used as a reference sample and was synthesised following a published synthesis. The precursors for the CDs include disperse blue 1 dye, phloroglucinol, m-phenylenediamine (m-PD), N, and N-dimethylformamide (DMF). The average diameter size of the CDs ranges from 1.5 to 15 nm. An excitation wavelength of 452 nm with a bandwidth of 45 nm was used to quantify the fluorescence in the pH range 5–9. Three CDs show a decreasing trend in FI with pH, while two CDs show an increasing trend. None of the CDs shows strong FL dependence. The FL changes around 0.5 ± 0.2 ns across the tested pH range. We suggest that the differences in the fluorescence trends can be attributed to the precursors chosen for synthesising the CDs.
Multi-objective pathfinder algorithm for multi-objective optimal power flow problem with random renewable energy sources: wind, photovoltaic and tidal
Authors: Li Ning , Zhou Guo , Zhou Yongquan , Deng Wu , Luo Qifang 
Published: June 2023

AbstractIn this paper, the multi-objective optimal power flow (MOOPF) problem optimization objectives focus on four optimization objectives: generation cost, emission, real power loss and voltage deviation (VD). Three renewable energy sources with successful industrial applications, including wind energy, solar energy, and tidal energy are introduced. Renewable energy supply is uncertain, so Weibull distribution probability, lognormal probability and Gumbel probability are used to calculate the instability and intermittency of wind energy, solar energy and tidal energy, respectively. The inclusion of four energy supplies on the IEEE-30 test system and the consideration of renewable energy reserves and penalty cost calculation improve the realism of the model. In order to obtain the control parameters that minimize the four optimization objectives, a named multi-objective pathfinder algorithm (MOPFA) based on elite dominance and crowding distance was proposed to solve this multi-objective optimization problem. Simulation results show the feasibility of the model, and MOPFA can get more evenly distributed Pareto front and provide more diverse solutions. A compromise solution was selected by the fuzzy decision system. Comparison with the recently published literature also shows that the proposed model can effectively reduce emissions and other indicators. In addition, the statistical test results show that MOPFA's multi-objective optimization performance ranks first. In solving this complex optimization problem, results show the MOPFA is superior to other multi-objective algorithms in optimization accuracy and speed.
Physicochemical features partially explain olfactory crossmodal correspondences
Authors: Ward Ryan J. , Wuerger Sophie M. , Ashraf Maliha , Marshall Alan 
Published: June 2023

AbstractDuring the olfactory perception process, our olfactory receptors are thought to recognize specific chemical features. These features may contribute towards explaining our crossmodal perception. The physicochemical features of odors can be extracted using an array of gas sensors, also known as an electronic nose. The present study investigates the role that the physicochemical features of olfactory stimuli play in explaining the nature and origin of olfactory crossmodal correspondences, which is a consistently overlooked aspect of prior work. Here, we answer the question of whether the physicochemical features of odors contribute towards explaining olfactory crossmodal correspondences and by how much. We found a similarity of 49% between the perceptual and the physicochemical spaces of our odors. All of our explored crossmodal correspondences namely, the angularity of shapes, smoothness of textures, perceived pleasantness, pitch, and colors have significant predictors for various physicochemical features, including aspects of intensity and odor quality. While it is generally recognized that olfactory perception is strongly shaped by context, experience, and learning, our findings show that a link, albeit small (6–23%), exists between olfactory crossmodal correspondences and their underlying physicochemical features.