bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of flaxseed lignan on the dynamics of Lactiplantibacillus plantarum and starter cultures in fermented milk
Authors: Thomas Elizabeth , Panjagari Narender Raju , Ganguly Sangita , Rashmi Hogarehalli Mallappa , Damodharan Pulikoden Veettil Swetha , Singh Ashish Kumar 
Published: April 2023

SummaryThe lignan from milled defatted flaxseed powder (DFP) and defatted hull powder (DHP) was extracted using direct alkaline hydrolysis and the quantity of lignan in the extract was estimated to be in the range of 11.74–14.30 mg g−1 flaxseed on a dry matter basis. Qualitative and quantitative analysis of different strains of Lactiplantibacillus plantarum (A1, Lp9, A5) along with yogurt mix culture (NCDC 146), Streptococcus salivarius ssp. thermophilus (NCDC 74) and Lactobacillus delbrueckii ssp. bulgaricus (NCDC 253) revealed that NCDC 74/A5 and NCDC 146/A5 co‐cultures are the most compatible. Buffalo milk containing different concentrations of lignan (100–400 mg of SDG/100 mL milk) was subjected to a fermentation dynamics study. The study revealed that the fermentation dynamics of Lactiplantibacillus plantarum in the milk did not get affected by starter cultures and flaxseed lignan. The results of this study could be useful in developing functional fermented probiotic milk products containing flaxseed lignan.
The biomechanical efficacy of a hybrid support surface in protecting supine patients from sacral pressure ulcers
Authors: Katz Tomer , Gefen Amit 
Published: April 2023

AbstractSupport surfaces are the most important pressure ulcer/injury prevention technology available to clinicians for protecting their at‐risk patients. A hybrid support surface marries the benefits of reactive and active support surfaces, by using high‐quality foam material inside inflatable air cells. When used in its “static mode”, it is a constant low air pressure mattress which delivers pressure redistribution in response to patient bodyweight and movements, by maximising the immersion and envelopment performance of the support surface. When used in its powered “dynamic mode”, this system further delivers alternating pressure care via the connected foam and air cells. Modes of action of hybrid support surfaces were never studied quantitatively before, excluding through the limited scope of interface pressure mapping. In this work, we developed a novel computational modelling framework and simulations to visualise and quantify the state of soft tissue loading at the buttocks of a supine patient positioned on a hybrid support surface, in both the static and dynamic modes. We found that the dynamic mode effectively shifts deep concentrated soft tissue loading from under the sacral bone (towards the sacral promontory) to the tip of the sacrum (coccyx) and vice versa, and thereby, generates a deep tissue offloading effect.
Barriers and facilitators to nurses addressing social needs and associated outcomes in the ambulatory setting in adult patients: Systematic review
Authors: Jackson Carolyn L. , Hood Elizabeth , Jenkins Julie A. , Szanton Sarah L. 
Published: April 2023

AbstractAimTo examine the barriers and facilitators nurses experience in addressing social needs in the United States and the associated outcomes of addressing these needs in adults in the ambulatory care setting.DesignA systematic review with inductive thematic and narrative synthesis.Data SourcesPubMed, CINAHL, Web of Science, and Embase from 2010 through 2021.Review MethodsCochrane Handbook of Systematic Reviews; Risk of Bias‐CASP and the JBI checklist; Certainty of evidence‐GRADE‐CERQual assessment.ResultsAfter duplicates were removed, 1331 titles and abstracts were screened, and a full‐text review was performed on 189 studies. Twenty‐two studies met inclusion criteria. The most frequently cited barriers to addressing social needs were lack of resources, workload burden, and lack of education in social needs. The most cited facilitators were engaging the person and family in decision‐making, a well‐integrated standardized data tracking and referral documentation system, clear communication within the clinic and with community partners, and specialized education and training. Seven studies measured the nurse's impact of screening for and addressing social needs, and outcomes improved in most of these studies.ConclusionBarriers and facilitators specific to nurses in the ambulatory setting and associated outcomes were synthesized. Limited evidence suggests that screening for social needs by nurses may impact outcomes by decreasing hospitalizations, decreasing emergency department utilization, and improving self‐efficacy towards medical and social services navigation.ImpactThese findings inform practice and facilitate changes within nursing towards care that accounts for a person's individual social needs in ambulatory care settings and are most directly applicable to nurses and administrators in the United States.Reporting MethodPRISMA guidelines, supplemented by the ENTREQ and SWiM guidelines.No Patient or Public ContributionThis systematic review is the result of work performed by the four authors exclusively.
The feasibility of daily monitoring in adolescents and young adults with mild intellectual disability or borderline intellectual functioning
Authors: Hulsmans Daan H. G. , Poelen Evelien A. P. , Lichtwarck‐Aschoff Anna , Otten Roy 
Published: April 2023

AbstractBackgroundIt is unclear whether the limitations of young persons with a mild intellectual disability or borderline intellectual functioning preclude feasibility of the daily diary method.MethodFor 60 consecutive days, 50 participants (Mage = 21.4, 56% male) who receive care in an ambulatory, residential, or juvenile detention setting, self‐rated both standardised and personalised diary questions through an app. Diary entries were used for feedback in treatment. Interviews were used to explore acceptability.ResultsAverage compliance was 70.4%, while 26% of participants dropped out. Compliance was good in ambulatory (88.9%) and residential care (75.6%), but not in the juvenile detention setting (19.4%). The content of self‐selected diary items varied widely. Participants deemed the method acceptable.ConclusionsDaily monitoring is feasible for individuals with a mild intellectual disability or borderline intellectual functioning receiving ambulatory or residential care, and can provide scientists and practitioners with important insights into day‐to‐day behavioural patterns.
Surprising pandemic experiences: A confrontation between principle‐based and virtue ethics, and a plea for virtue ethics training for medical students and residents. A rudimentary outline of a four‐step model
Authors: Zuckerman Shlomit , Kimsma Gerrit K. , Devisch Ignaas 
Published: April 2023

AbstractBackgroundIn past years, physicians have, with a certain continuity, reported increasing numbers of burnout, depression and compassion fatigue in their daily practice. These problems were attributed, not only but also, to a loss of public trust and an increase in violent behaviour of patients and family members towards medical professionals in all walks of life. Recently, however, during the breakout of the coronavirus disease 2019 (COVID‐19) pandemic in 2020, there were public expressions of appreciation and respect for health care workers that almost universally have been assessed as indications of a re‐establishment of public trust in physicians and appreciation for the medical professions' commitments. In other words, shared experiences of what society was in need of: the experience of a ‘common good’. Those responses during the COVID‐19 pandemic increased positive feelings among practicing physicians, such as commitment, solidarity, competency, and experiences concerning obligations for the common good and a sense of belonging to one and the same community for all. Essentially, these responses of raised self‐awareness of commitment and solidarity between (potential) patients and medical personal point towards the social importance and power of these values and virtues. This shared domain in ethical sources of behaviour seems to hold a promise of overcoming gaps between the different spheres of doctors and patients. That promise justifies stressing the relevance of this shared domain of Virtue Ethics in the training of physicians.MethodsIn this article, therefore, we shall make a plea for the relevance of Virtue Ethics before proposing an outline of an educational programme for Virtue Ethics training for medical students and residents. Let us start by very briefly presenting on Aristotelian virtues and its relevance to modern medicine in general, and during the current pandemic in particular.ResultsWe shall follow up this short presentation by a Virtue Ethics Training Model and the respective settings in which it takes place. This model has four steps as follows: (a) include moral character literacy in the formal curriculum; (b) provide ethics role modelling and informal training in moral character in the healthcare setting by senior staff; (c) create and apply regulatory guidelines regarding virtues and rules; and (d) assess success of training by evaluation of moral character of physicians.ConclusionApplying the four‐step model may contribute to strengthening the development of moral character in medical students and residents, and decrease the negative consequences of moral distress, burnout and compassion fatigue in health care personnel. In the future, this model should be empirically studied.
Nurse‐led shared decision‐making on complementary therapy use by patients with diabetes: An participatory action research
Authors: Chang Hsiao‐Yun , Mao Pei‐Ling , Huang Chun‐Yu 
Published: April 2023

AbstractAimsThe aim of this study was to develop, implement and evaluate a nurse‐led shared decision‐making model of care for discussing the use of complementary and alternative medicine with diabetic patients and to explore to what extent the risk–benefit assessment of using complementary and alternative medicine can provide a framework for facilitating nurse–patient dialogue and strengthening patient involvement in their disease management.DesignParticipatory action research with pre‐post intervention.MethodsA two‐run cycle of action and spirals from participatory action research was undertaken using a purposive sampling method to involve healthcare professionals and diabetic patients from September 2021 to June 2022. The nurse‐led shared decision‐making model of care was designed and implemented congruent with participatory action research principles. Quantitative measures were collected about patients' perceived involvement in shared decision‐making and their understanding of the risks and benefits of using complementary and alternative medicine. Patients' outcomes of disease control (fasting plasma glucose and HbA1c) were also collected. Data were analysed using IBM SPSS software (version 28). Interviews were summarized using thematic analysis. An EQUATOR Network guideline for participatory action research supported the preparation of this paper.ResultsComparison of pre‐post intervention outcomes showed that patients' scale scores on shared decision‐making involvement and understanding of the risk–benefit of using complementary and alternative medicine improved significantly after implementing the model. Fasting plasma glucose improved only slightly after a 3‐month follow‐up.ConclusionsThe care model strengthens patient involvement in their disease management and makes appropriate decisions about CAM use that should reduce potentially harmful side effects or interactions between CAM and conventional medicine.Implications for the Profession and Patient CareThe shared decision‐making model of care incorporates evidence‐based CAM research into practice, facilitates the standardization of CAM management in diabetes, improves care options for patients and educates nurses about CAM use in managing diabetes.Patient or Public ContributionNo Patient or Public Contribution.
Opacity in bargaining over public good provision
Authors: Lamprecht Julian , Thum Marcel 
Published: April 2023

AbstractWe consider ultimatum bargaining over the provision of a public good. Offer‐maker and responder can delegate their decisions to agents whose actual decision rules are opaque. We show that the responder will benefit from strategic opacity, even with bilateral delegation. The incomplete information created by strategic opacity choices does not lead to inefficient negotiation failure in equilibrium. Inefficiencies arise from an inefficient provision level. While an agreement will always be reached, the public good provision will fall short of the socially desirable level. Compared with unilateral delegation, bilateral delegation is never worse from a welfare perspective.
Lumbar Intradural Disc Herniation Caused by Injury: A Case Report and Literature Review
Authors: Jin Yuan‐zhang , Zhao Bin , Zhao Xiao‐feng , Lu Xiang‐dong , Fan Zhi‐feng , Wang Chong‐jie , Qi De‐tai , Wang Xiao‐nan , Zhou Run‐tian , Zhao Yi‐bo 
Published: April 2023

BackgroundIntradural disc herniation(IDH) caused by trauma is a rare type of disease，which is difficult to diagnose clinically and is easily misdiagnosed. We received a patient with the disease, reported the case to share the process of diagnosis and treatment and put forward our own opinions, so as to increase the probability of correct diagnosis.Case PresentationWe report the case of a 48‐year‐old male who fell from a scaffold at a height of 2 m. Later, he developed low back pain, restricted movement, numbness and hyperalgesia of the lower left limb, and decreased left muscle strength. He was diagnosed with IDH. Treatment with posterior decompression and intramedullary decompression with pedicle screw internal fixation was performed. His postoperative course was uneventful, and he underwent regular follow up for 1 year. Good neurologic symptom improvement was achieved.ConclusionsIDH is rare, and comprehensive consideration and film reading can improve the correct diagnosis rate. Accurate diagnosis and early decompression of laminae and intramedullary decompression can lead to good recovery after neurologic impingement.
Mast cells—fetal mast cells crosstalk with maternal interfaces during pregnancy: Friend or foe?
Authors: Msallam Rasha , Redegeld Frank A. 
Published: April 2023

AbstractMast cells (MC) are hematopoietic immune cells that play a major role during allergic reactions in adults by releasing a myriad of vasoactive and inflammatory mediators. MC seed all vascularized tissues and are most prominent in organs with a barrier function such as skin, lungs, and intestines. These secreted molecules cause mild symptoms such as localized itchiness and sneezing to life‐threatening symptoms (i.e., anaphylactic shock). Presently, despite the extensive research on Th2‐mediated immune responses in allergic diseases in adults, we are still unable to determine the mechanisms of the role of MC in developing pediatric allergic (PA) disorders. In this review, we will summarize the most recent findings on the origin of MC and discuss the underappreciated contribution of MC in the sensitization phase to maternal antibodies during pregnancy in allergic reactions and other diseases such as infectious diseases. Then, we will lay out potential MC‐dependent therapeutic strategies to be considered in future investigations to understand the remaining gaps in MC research for a better quality of life for these young patients.
Management of high‐dose intrathecal baclofen pump explant: A case report
Authors: Belisle Haley Campbell , Agrawal Mrinal , Newton Keith , Yeung Brent , Dayal Rakhi 
Published: April 2023

AbstractBackgroundIntrathecal baclofen (ITB) is a proven, effective treatment for refractory spasticity and chronic pain, with applications ranging from spinal cord injury to amyotrophic lateralsclerosis (ALS). Despite its effectiveness, the withdrawal syndrome of intrathecal baclofen can be life‐threatening.Case ReportThis case describes the treatment of a patient with chronic spasticity related to ALS with an ITB pump infection requiring explant and a prolonged period of antibiotics before reimplantation. A 62‐year‐old man with ALS‐related spasticity maintained on high‐dose ITB for 20 years presented to the emergency department with one week of fever, confusion, and localized erythema to the R‐side of his abdomen. Laboratories indicated a mild leukocytosis 12.9 K/uL and imaging showed a 2.9‐cm fluid collection with fat stranding surrounding the ITB pump. The pack was explanted, and the patient started on intravenous antibiotics. Due to the high baclofen dosage, our pain service recommended PO (per os) baclofen 30 mg every 6 h via gastrostomy and PO diazepam 10 mg every 6 h via gastrostomy. These doses were titrated carefully to avoid oversedation while preventing withdrawal symptoms. On Day 23 postexplant, the patient had the baclofen pump reimplanted and baclofen titrated over three days to his previous dose of ITB.ConclusionThis case demonstrates a successful approach to avoiding severe baclofen withdrawal using PO baclofen combined with PO diazepam. The high dose of maintenance ITB (1188.8 mcg/day), the inability to reinsert the patient's intrathecal pump, and the high risk of intubation in a patient with severe neuromuscular dysfunction all made this a challenging case.
Applying Latent Dirichlet Allocation and Support Vector Regression to the Aesthetic Design of Medical Nursing Beds
Authors: Yuan Bingkun , Ye Junnan , Wu Xinying , Yang Chaoxiang 
Published: April 2023

Abstract
With the development of social productivity and the improvement in material living standards, emotional value has become the core driver of the enhancement of product market competitiveness. A medical nursing bed, one of the most typical types of medical devices, is designed with little attention to the emotional experience of the users. Therefore, this paper proposes an innovative perceptual design approach under the Kansei engineering (KE) framework for resource-limited and information-poor companies. It guides the aesthetic design of medical nursing beds by constructing a mapping relationship between users’ perceptual needs and the design characteristics of medical nursing beds to maximize users’ emotions. First, latent Dirichlet allocation (LDA) is used to extract usable Kansei semantics from big data, compensating for the subjectivity of traditional KE data input. Then, the design characteristics obtained after deconstructing a medical nursing bed are simplified with rough set theory (RST). Finally, a mapping model between users’ perceptual needs and the core design characteristics of nursing beds is established through support vector regression (SVR), and the optimal design solution is obtained by weighting calculation. The optimal combination of design characteristics for medical nursing beds is finally obtained. The results suggest that the design method proposed in this paper can help designers accurately grasp users’ emotional perceptions in terms of aesthetic design and scientifically guide and complete the design of new medical nursing beds, verifying the feasibility and scientificity of the proposed method in terms of aesthetic design.
Making sense of shear zone fabrics that record multiple episodes of deformation: Electron backscatter diffraction–derived and crystallographic vorticity axis–enhanced petrochronology
Authors: Miranda Elena A. , Brown Virginia , Schwartz Joshua J. , Klepeis Keith A. 
Published: April 2023

Abstract
We present a new method of linking microstructures, electron backscatter diffraction (EBSD)–derived crystallographic vorticity axis (CVA) analysis, and titanite petrochronology to directly link fabric development to specific deformation events in shear zone rocks with complex histories. This approach is particularly useful where overprinting is incomplete, such that it is unknown which fabric is being dated by the petrochronometer. Here, we compared single-phase CVA patterns of fabric-forming minerals with those of synkinematic petrochronometers (e.g., titanite) to associate the timing of fabric development with deformational events in the middle crust of the George Sound shear zone, Fiordland, New Zealand. The host rocks to the George Sound shear zone include the Carboniferous Large Pluton, where titanite petrochronology demonstrates an unequivocally Cretaceous age of metamorphic titanite growth within mylonitic foliation. However, the host rocks show two distinct CVA patterns: a transtensional deformation event recorded by quartz and plagioclase, and a pure-shear–dominated transpressional deformation event recorded by biotite and titanite. Therefore, the transpressional CVA pattern of the titanite, coupled with its Cretaceous age, shows that it cannot be used to date the quartz and plagioclase fabric developed in response to an older transtensional deformation event. These results demonstrate the necessity of combining EBSD and CVA analysis with petrochronology to demonstrate that synkinematic accessory phase petrochronometers show the same kinematic deformation geometry (i.e., CVA pattern) as the fabric being dated.
Changing from face-to-face to virtual meetings due to the COVID-19 pandemic: protocol for a mixed-methods study exploring the impact on cancer multidisciplinary team (MDT) meetings
Authors: McInnerney Daisy , Chung Donna , Mughal Muntzer , Onifade Anjola , Holden David , Goodman Jacob , Birchall Martin , Peake Michael D , Quaife Samantha L 
Published: April 2023

IntroductionIn the UK, the National Cancer Plan (2000) requires every cancer patient’s care to be reviewed by a multidisciplinary team (MDT). Since the introduction of these guidelines, MDTs have faced escalating demands with increasing numbers and complexity of cases. The COVID-19 pandemic has presented MDTs with the challenge of running MDT meetings virtually rather than face-to-face.This study aims to explore how the change from face-to-face to virtual MDT meetings during the COVID-19 pandemic may have impacted the effectiveness of decision-making in cancer MDT meetings and to make recommendations to improve future cancer MDT working based on the findings.Methods and analysisA mixed-methods study with three parallel phases:Semistructured remote qualitative interviews with ≤40 cancer MDT members.A national cross-sectional online survey of cancer MDT members in England, using a validated questionnaire with both multiple-choice and free-text questions.Live observations of ≥6 virtual/hybrid cancer MDT meetings at four NHS Trusts.Participants will be recruited from Cancer Alliances in England. Data collection tools have been developed in consultation with stakeholders, based on a conceptual framework devised from decision-making models and MDT guidelines. Quantitative data will be summarised descriptively, and χ2tests run to explore associations. Qualitative data will be analysed using applied thematic analysis. Using a convergent design, mixed-methods data will be triangulated guided by the conceptual framework.The study has been approved by NHS Research Ethics Committee (London—Hampstead) (22/HRA/0177). The results will be shared through peer-reviewed journals and academic conferences. A report summarising key findings will be used to develop a resource pack for MDTs to translate learnings from this study into improved effectiveness of virtual MDT meetings.The study has been registered on the Open Science Framework (https://doi.org/10.17605/OSF.IO/D2NHW).