bluuebunny/crossref_metadata_2025_split huggingface dataset:
US and international per- and polyfluoroalkyl substances surface water quality criteria: A review of the status, challenges, and implications for use in chemical management and risk assessment
Authors: Ruffle Betsy , Archer Christine , Vosnakis Kelly , Butler Josh D. , Davis Craig W. , Goldsworthy Belinda , Parkman Rick , Key Trent A. 
Published: April 2023

Abstract
Regulation of per- and polyfluorinated substances (PFAS) in surface water is a work-in-progress with relatively few criteria promulgated in the United States and internationally. Surface water quality criteria (SWQC) or screening values derived for perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) by Australia, Canada, the European Union (EU), and four US states (Florida, Michigan, Minnesota, and Wisconsin), and the San Francisco Bay Regional Water Quality Control Board (SFB RWQCB; California) were compared. Across these eight jurisdictions, promulgated numeric criteria for the same compound and receptor span over five orders of magnitude as a result of different approaches and data interpretations. Human health criteria for PFOS range from 0.0047 to 600 ng/L depending on route of exposure (e.g., fish consumption or drinking water) and are lower than most ecological criteria for protection of aquatic and wildlife receptors. Data gaps and uncertainty in chronic toxicity and bioaccumulation of PFOS and PFOA, as well as the use of conservative assumptions regarding intake and exposure, have resulted in some criteria falling at or below ambient background concentrations and current analytical detection limits (around 1 ng/L for commercial laboratories). Some jurisdictions (e.g., Australia, Canada) have deemed uncertainty in quantifying water-fish bioaccumulation too great and set fish tissue action levels in lieu of water criteria. Current dynamics associated with the emerging and evolving science of PFAS toxicity, exposure, and environmental fate (i.e., data gaps and uncertainty), as well as the continuous release of scientific updates, pose a challenge to setting regulatory limits. Integr Environ Assess Manag 2024;20:36–58. © 2023 AECOM Technical Services, Inc and The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Evaluating the perceptions of pesticide use, safety, and regulation and identifying common pesticide-related topics on Twitter
Authors: Jun Inyoung , Feng Zheng , Avanasi Raghavendhran , Brain Richard A. , Prosperi Mattia , Bian Jiang 
Published: April 2023

Abstract
Synthetic pesticides are important agricultural tools that increase crop yield and help feed the world's growing population. These products are also highly regulated to balance benefits and potential environmental and human risks. Public perception of pesticide use, safety, and regulation is an important topic necessitating discussion across a variety of stakeholders from lay consumers to regulatory agencies since attitudes toward this subject could differ markedly. Individuals and organizations can perceive the same message(s) about pesticides differently due to prior differences in technical knowledge, perceptions, attitudes, and individual or group circumstances. Social media platforms, like Twitter, include both individuals and organizations and function as a townhall where each group promotes their topics of interest, shares their perspectives, and engages in both well-informed and misinformed discussions. We analyzed public Twitter posts about pesticides by user group, time, and location to understand their communication behaviors, including their sentiments and discussion topics, using machine learning-based text analysis methods. We extracted tweets related to pesticides between 2013 and 2021 based on relevant keywords developed through a “snowball” sampling process. Each tweet was grouped into individual versus organizational groups, then further categorized into media, government, industry, academia, and three types of nongovernmental organizations. We compared topic distributions within and between those groups using topic modeling and then applied sentiment analysis to understand the public's attitudes toward pesticide safety and regulation. Individual accounts expressed concerns about health and environmental risks, while industry and government accounts focused on agricultural usage and regulations. Public perceptions are heavily skewed toward negative sentiments, although this varies geographically. Our findings can help managers and decision-makers understand public sentiments, priorities, and perceptions and provide insights into public discourse on pesticides. Integr Environ Assess Manag 2023;19:1581–1599. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Butterfly, Vinylidene‐Like, Monobridged and Trans Structures of Si2H2+: Comparison to the Well‐Characterized Neutral Si2H2
Authors: Schueller Kailyn M. , Mull Henry F. , Turney Justin T. , Schaefer Henry F. 
Published: April 2023

AbstractThis paper investigates four of the constitutional isomers of Si2H2+, namely the butterfly, vinylidene‐like, monobridged, and trans structures. These isomer geometries were all studied using the CCSD(T) method with basis sets as large as cc‐pV5Z. Higher level methods CCSDT and CCSDT(Q) were used for final energetics. It is found that the butterfly isomer has the lowest energy, followed by vinylidene‐like and monobridged structures; the trans structure has the highest energy of the four. All structures were compared with their neutral counterparts. Partial charges are computed and it is found that all isomers share the positive charge between the silicon atoms. NBO analysis shows that the cation Si−Si bond order is reduced by 0.5 relative to the neutral versions of the same isomer in the case of the butterfly, vinylidene‐like, and monobridged; and reduced by 0.6 for the trans isomer. Vibrational frequencies, infrared intensities, and dipole moments are predicted to encourage the spectroscopic identification of Si2H2+.
Incidence of maternal venous thromboembolism in China: A systematic review and meta‐analysis
Authors: Luo Xingrong , Shan Dan , Zhang Lin , Wu Yuxia , Li Tao , Ren Yu , Hu Yayi 
Published: April 2023

AbstractBackgroundVenous thromboembolism (VTE) is one of the primary causes of maternal death. Although many studies have reported maternal VTE, no study has estimated the incidence of it in China.ObjectivesThe aim of this work was to estimate the incidence of maternal VTE in China and to compare the risk factors for it.Search strategyThe authors searched eight platforms and databases including PubMed, Embase, and Cochrane Library from inception to April 2022, with the search terms “venous thromboembolism” AND “puerperium (pregnancy)” AND “incidence” AND “China.”Selection criteriaStudies provide data to calculate the incidence of maternal VTE among Chinese patients.Data collection and analysisThe authors made a standardized table to collect data and calculated the incidence and 95% confidence intervals (CIs), founding source of heterogeneity by subgroup analysis and meta‐regression and judging publication bias by funnel plot and Egger test.Main resultsThe included 53 papers with a total sample size of 3 813 871 patients had 2539 cases of VTE, and the incidence of maternal VTE in China was 0.13% (95% CI, 0.11–0.16; P < 0.001).ConclusionsThe trend in the incidence of maternal VTE in China is stable. Cesarean section and advanced age are associated with a higher incidence of VTE.
Are ureterolysis for deep endometriosis really all the same? An anatomical classification proposal for ureterolysis: A single‐center experience
Authors: Ianieri Manuel Maria , Nardone Alessandra De Cicco , Pavone Matteo , Benvenga Greta , Pafundi Maria Pia , Campolo Federica , Foschi Nazario , Greco Pierfrancesco , Brutto Mariafrancesca , Scambia Giovanni 
Published: April 2023

AbstractObjectiveUreteral endometriosis has an incidence of 0.1% to 1%. The type of surgery required is either conservative (ureterolysis) or radical treatment, depending on the degree of ureter infiltration. The incidence of intraoperative and postoperative complications is heterogeneous. Thus, the aim of the current study was to propose a classification of ureterolysis based on the anatomical structure of the ureter and differing complication rates with procedures.MethodsA total of 139 ureterolysis procedures were included in the study. Patients were divided into three groups according to the depth of ureterolysis required. Differences were recorded across the three types of ureterolysis in terms of intraoperative and postoperative complications.ResultsThe incidence of ureteral fistula was reported in 0.7% of cases, with postoperative ureteral stenosis in 2% of type 2 ureterolysis. In the case of type 3 ureterolysis, after conservative procedures, 52.9% of patients required an ureteroneocystostomy to solve the ureteral stenosis.ConclusionThe risk of ureteral injury and ureteroneocystostomy after conservative procedures appears to be associated with type 3 ureterolysis, probably due to excessive devascularization, secondary to the incision of adventitia. Obviously, these data should be confirmed through a prospective study of a larger number, but our proposed classification can provide the basis for making data from future studies more comparable.
Acanthoscurria gomesiana spider‐derived Mygalin in the prelimbic prefrontal cortex modulates neuropathic pain and depression comorbid
Authors: Medeiros Ana Carolina , Medeiros Priscila , Ruggiero Rafael Naime , De Gregorio Danilo , Gobbi Gabriella , Silva Júnior Pedro Ismael , dos Santos Wagner Ferreira , Coimbra Norberto Cysne , de Freitas Renato Leonardo 
Published: April 2023

AbstractDepression has a high rate of comorbidity with neuropathic pain. This study aims to investigate the effect of Mygalin, an acylpolyamine synthesized from a natural molecule in the hemolymph of the Acanthoscurria gomesiana spider, injected into the prelimbic (PrL) region of the medial prefrontal cortex on chronic neuropathic pain and depression comorbidity in rats. To investigate that comorbidity, neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve in male Wistar rats. The biotinylated biodextran amine (BDA) bidirectional neural tract tracer was microinjected into the PrL cortex to study brain connections. Rodents were further subjected to von Frey (mechanical allodynia), acetone (cold allodynia), and forced swim (depressive‐like behavior) tests. BDA neural tract tracer‐labeled perikarya were found in the dorsal columns of the periaqueductal gray matter (dPAG) and the dorsal raphe nucleus (DRN). Neuronal activity of DRN neurons decreased in CCI rats. However, PrL cortex treatment with Mygalin increased the number of spikes on DRN neurons. Mygalin treatment in the PrL cortex decreased both mechanical and cold allodynia and immobility behavior in CCI rats. PrL cortex treatment with N‐methyl‐D‐aspartate (NMDA) receptor receptors attenuated the analgesic and antidepressive effects caused by Mygalin. The PrL cortex is connected with the dPAG and DRN, and Mygalin administration into the PrL increased the activity of DRN neurons. Mygalin in the PrL cortex produced antinociceptive and antidepressive‐like effects, and the NMDA agonist reversed these effects.
Sudden gains and deteriorations: Modeling the impact across outcomes with university counseling center clients
Authors: Drinane Joanna M. , Owen Jesse , Kopta S. Mark 
Published: April 2023

AbstractObjectiveThis study examines the longitudinal impact of sudden gains/deteriorations across the outcomes associated with the phase model.MethodIn a sample of 16,657 clients who completed the Behavioral Health Measure‐20, we identified sudden gains/deteriorations and employed multilevel piecewise analyses to assess their impact on subsequent treatment phases.ResultsWe found that: (1) Following a sudden gain in the well‐being outcome, the mean‐level for the symptom outcome increased (meaning symptoms improved), and the rate of change decreased, (2) Following a sudden gain in the symptom outcome, the mean‐level for the life functioning outcome increased, (3) Following a sudden deterioration in the well‐being outcome, the mean‐level and rate of change for the symptom outcome decreased, and (4) Following a sudden deterioration in the symptom outcome, the mean‐level for the life functioning outcome decreased.ConclusionsThese findings reveal that sudden gains/deteriorations function and occur at different rates across phases of change in psychotherapy.
A 3‐year qualitative evaluation of interprofessional team‐based clinical education at an Australian dental school
Authors: Storrs Mark J. , Henderson Amanda J. , Kroon Jeroen , Evans Jane L. , Love Robert M. 
Published: April 2023

AbstractPurpose/ObjectivesThis article describes a qualitative evaluation of interprofessional (IP) team‐based treatment planning (TBTP) involving dentistry, oral health therapy, dental prosthetics, and dental technology students at the Griffith University School of Dentistry and Oral Health (DOH). Using the same data from a recently published article that looked solely at the quantitative evaluation of TBTP, this article focuses on the qualitative evaluation of TBTP. This evaluation explores the contextual meaning related to the previously published aspects of TBTP that contributed positively toward oral health students’ IP clinical learning and identifies themes reflecting students’ IP clinical experience.MethodsThematic analysis of transcripts from nine focus groups, comprised of 46 final year students and open‐ended questions collected from 544 students through an online instrument from 2012 to 2014, explored the question: “What is the contribution of IP student team‐based processes on students’ perceptions of IP learning and practice at DOH?”ResultsResponses from online participants and student focus groups revealed three major themes: useful role learning, communication confidence, and pro‐active collaborative teamwork. Throughout each of these themes, students stated they possessed a confidence in collaborating with other oral health students as exhibited through an understanding of profession‐specific and IP roles, self‐assurance in communicating, and teamwork skills.ConclusionAspects of TBTP that contributed positively toward students’ IP clinical learning and practice were meaningfully identified.
Controlled self‐cleaning aluminum surfaces mediated by anodic aluminum oxide
Authors: Zhang Qi , Huang Zhichao , Shao Ruijuan , Chen Junjie , Zang Dongmian 
Published: April 2023

AbstractSpecial porous anodic aluminum oxide (AAO) membranes are created on Al in a phosphonic acid electrolyte solution through one‐step anodic oxidation and modified with polydimethysiloxane using a vapor deposition technique. In this context, the anodic oxidation time is tuned during its process. As such, the Al surface's wettability, and self‐cleaning property are controlled by the tunable anodic oxidation time, for the anodic oxidation, time can regulate the structure of the AAO and the proportion of the air‐liquid interface.
Application of oncolytic virus in tumor therapy
Authors: Huang Zhijian , Guo Hongen , Lin Lin , Li Shixiong , Yang Yong , Han Yuanyuan , Huang Weiwei , Yang Jialiang 
Published: April 2023

AbstractOncolytic viruses (OVs) can selectively kill tumor cells without affecting normal cells, as well as activate the innate and adaptive immune systems in patients. Thus, they have been considered as a promising measure for safe and effective cancer treatment. Recently, a few genetically engineered OVs have been developed to further improve the effect of tumor elimination by expressing specific immune regulatory factors and thus enhance the body's antitumor immunity. In addition, the combined therapies of OVs and other immunotherapies have been applied in clinical. Although there are many studies on this hot topic, a comprehensive review is missing on illustrating the mechanisms of tumor clearance by OVs and how to modify engineered OVs to further enhance their antitumor effects. In this study, we provided a review on the mechanisms of immune regulatory factors in OVs. In addition, we reviewed the combined therapies of OVs with other therapies including radiotherapy and CAR‐T or TCR‐T cell therapy. The review is useful in further generalize the usage of OV in cancer treatment.
A machine learning model for predicting serum neutralizing activity against Omicron SARS‐CoV‐2 BA.2 and BA.4/5 sublineages in the general population
Authors: Camacho Jorge , Albert Eliseo , Álvarez‐Rodríguez Beatriz , Rusu Luciana , Zulaica Joao , Moreno Alicia Rodríguez , Peiró Salvador , Geller Ron , Navarro David , Giménez Estela 
Published: April 2023

AbstractSupervised machine learning (ML) methods have been used to predict antibody responses elicited by COVID‐19 vaccines in a variety of clinical settings. Here, we explored the reliability of a ML approach to predict the presence of detectable neutralizing antibody responses (NtAb) against Omicron BA.2 and BA.4/5 sublineages in the general population. Anti‐SARS‐CoV‐2 receptor‐binding domain (RBD) total antibodies were measured by the Elecsys® Anti‐SARS‐CoV‐2 S assay (Roche Diagnostics) in all participants. NtAbs against Omicron BA.2 and BA4/5 were measured using a SARS‐CoV‐2 S pseudotyped neutralization assay in 100 randomly selected sera. A ML model was built using the variables of age, vaccination (number of doses) and SARS‐CoV‐2 infection status. The model was trained in a cohort (TC) comprising 931 participants and validated in an external cohort (VC) including 787 individuals. Receiver operating characteristics analysis indicated that an anti‐SARS‐CoV‐2 RBD total antibody threshold of 2300 BAU/mL best discriminated between participants either exhibiting or not detectable Omicron BA.2 and Omicron BA.4/5‐Spike targeted NtAb responses (87% and 84% precision, respectively). The ML model correctly classified 88% (793/901) of participants in the TC: 717/749 (95.7%) of those displaying ≥2300 BAU/mL and 76/152 (50%) of those exhibiting antibody levels <2300 BAU/mL. The model performed better in vaccinated participants, either with or without prior SARS‐CoV‐2 infection. The overall accuracy of the ML model in the VC was comparable. Our ML model, based upon a few easily collected parameters for predicting neutralizing activity against Omicron BA.2 and BA.4/5 (sub)variants circumvents the need to perform not only neutralization assays, but also anti‐S serological tests, thus potentially saving costs in the setting of large seroprevalence studies.
Long‐term risk of herpes zoster following COVID‐19: A retrospective cohort study of 2 442 686 patients
Authors: Chen Yi‐Chen , Ho Chung‐Han , Liu Ting‐Hui , Wu Jheng‐Yan , Huang Po‐Yu , Tsai Ya‐Wen , Lai Chih‐Cheng 
Published: April 2023

AbstractThe long‐term risk of herpes zoster (HZ) after recovery from a SARS‐CoV‐2 infection is unclear. This retrospective cohort study assessed the risk of HZ in patients following a COVID‐19 diagnosis. This retrospective, propensity score‐matched cohort study was based on the multi‐institutional research network TriNetX. The risk of incident HZ in patients with COVID‐19 was compared with that of those not infected with SARS‐CoV‐2 during a 1‐year follow‐up period. Hazard ratios (HRs) and 95% confidence intervals (CIs) of HZ and its subtypes were calculated. This study identified 1 221 343 patients with and without COVID‐19 diagnoses with matched baseline characteristics. During the 1‐year follow‐up period, patients with COVID‐19 had a higher risk of HZ compared with those without COVID‐19 (HR: 1.59; 95% CI: 1.49–1.69). In addition, compared with the control group patients, those with COVID‐19 had a higher risk of HZ ophthalmicus (HR: 1.31; 95% CI: 1.01–1.71), disseminated zoster (HR: 2.80; 95% CI: 1.37–5.74), zoster with other complications (HR: 1.46; 95% CI: 1.18–1.79), and zoster without complications (HR: 1.66; 95% CI: 1.55–1.77). Kaplan–Meier curve analysis (log‐rank p < 0.05) results indicated that the risk of HZ remained significantly higher in patients with COVID‐19 compared with those without COVID‐19. Finally, the higher risk of HZ in the COVID‐19 cohort compared with that in the non‐COVID‐19 cohort remained consistent across subgroup analyses regardless of vaccine status, age, or sex. The risk of HZ within a 12‐month follow‐up period was significantly higher in patients who had recovered from COVID‐19 compared with that in the control group. This result highlights the importance of carefully monitoring HZ in this population and suggests the potential benefit of the HZ vaccine for patients with COVID‐19.
Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication
Authors: Lv Mengjiao , Yao Ting , Zhang Yi , Ma Siyuan , Chen Jinmei , Tang Zhenghao , Zang Guoqing , Chen Xiaohua 
Published: April 2023

AbstractHepatitis B virus (HBV) specific T cell immune response plays a vital role in viral clearance. Dendritic cell derived exosomes (Dexs) can activate T cell immunity effectively. Tapasin (TPN) is involved in antigen processing and specific immune recognition. In the present study, we elucidated that Dexs loading TPN (TPN‐Dexs) could enhance CD8+ T cell immune response and inhibit virus replication in HBV transgenic mice. T cell immune response and the ability of inhibiting HBV replication were measured in HBV transgenic mice immunized with TPN‐Dexs. Meanwhile, CD8+ T cell autophagy and specific T cell immune responses were measured in vitro and vivo, and the mechanisms probably involved in were explored. Purified TPN‐Dexs could be taken up into the cytoplasm of DCs and upregulate CD8+ T cell autophagy to enhance specific T cell immune response. In addition, TPN‐Dexs could increase the expression of AKT and decrease the expression of mTOR in CD8+ T cells. Further research confirmed that TPN‐Dexs could inhibit virus replication and decrease the expression of HBsAg in the liver of HBV transgenic mice. Nevertheless, those also could elicit mice hepatocytes damage. In conclusion, TPN‐Dexs could enhance specific CD8+ T cell immune responses via the AKT/mTOR pathway to regulate the autophagy and exert the antiviral effect in HBV transgenic mice.
Association between skeletal muscle index prior to liver transplantation and 1‐year mortality posttransplant
Authors: Bot Daphne , Klerks Suzanne , Leistra Eva , Tushuizen Maarten E. , van Hoek Bart 
Published: April 2023

AbstractBackgroundLiver transplantation is the only curative therapy for end‐stage liver disease (ESLD). Sarcopenia is often defined as the loss of muscle quantity (skeletal muscle index [SMI]), but muscle attenuation (MA), a surrogate marker of muscle quality, is also decreased in ESLD. We assessed pre–liver transplant SMI and MA and their association with posttransplant mortality, complications, and length of intensive care unit (ICU) and hospital stay.MethodsIn 169 consecutive patients with ESLD who underwent a liver transplantation between 2007 and 2014, SMI and MA were measured on computed tomography scans at time of placement on the waiting list for liver transplantation. The primary outcome of interest was 1‐year posttransplant mortality. Secondary posttransplantation outcomes of interest were complications within 30 days and length of stay in the ICU > 3 days and in the hospital >3 weeks. Logistic and Cox regression analyses were performed.ResultsMA was associated with 1‐year posttransplant mortality rate (hazard ratio=0.656, 95% CI=0.464–0.921, P = 0.015). The highest quartile of SMI had a lower odds for the total length of stay in the hospital lasting >3 weeks (odds ratio=0.211, 95% CI=0.061–0.733, P = 0.014). MA was associated with a prolonged ICU stay; this was, however, not statistically significant after adjustment for age, sex, and Model for ESLD score.ConclusionLower MA is associated with a longer length of ICU stay and 1‐year mortality after liver transplantation, whereas low SMI was associated with a total length of hospital stay.