bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routine outcome monitoring (ROM) and feedback in university student counselling and mental health services: Considerations for practitioners and service leads
Authors: Barkham Michael , Broglia Emma ,   The SCORE Consortium
Published: September 2023

AbstractAimRoutine outcome monitoring (ROM), including the use of feedback, has become a much vaunted method in psychological therapies but is little used in university/college counselling and mental health services, perhaps because its adoption raises questions for many practitioners and service leaders. There is a need for both clinical‐ and research‐based statements to clarify the reasoning and rationale for ROM. This paper aims to present and respond to common challenges of and reservations about using ROM in student counselling and/or mental health services.MethodThe article poses 15 questions and issues about the adoption of ROM drawn from the literature on this topic and further refined by practitioner‐ and researcher‐members of a consortium comprising service leads, practitioners, and researchers working in the field of student counselling in the UK. The questions address nine themes: (1) the purpose and yield of ROM; (2) the burden of measurement; (3) the impact on clients and process of therapy; (4) consistency with therapeutic theory; (5) client groups and settings; (6) concern from practitioners; (7) equality, diversity, and inclusion; (8) implementation; and (9) relationship with the paradigm of practice‐based evidence.FindingsResponses to each of the 15 questions are provided from a methodological, evidence‐based, and clinical perspective.ConclusionsThe responses provide practitioners with the necessary information to enable them to make informed decisions as to the value, or otherwise, of adopting ROM, including feedback, in the delivery of counselling interventions, and generating evidence created from clinical practice.
Anterior graft migration in posterior lumbar interbody fusion: A case report and literature review
Authors: Hashimoto Masanori , Hirata Hirohito , Tsukamoto Masatsugu , Tomohito Yoshihara , Mawatari Masaaki , Morimoto Tadatsugu 
Published: September 2023

Key Clinical MessageSpine surgeons should be aware of the possibility of anterior displacement of the grafted bone during PLIF and the potential for severe complications that may arise because of such displacement so that preparations can be made for a proper response.AbstractWe report two cases of anterior displacement of the grafted bone after posterior lumbar interbody fusion (Graphical Abstract A‐D). The patients did not require additional surgery. The anterior migration of grafted bone or cage can cause damage to anterior organs and blood vessels. Therefore, a careful surgical procedure is necessary.
Anesthetic management of a pediatric patient with methylmalonic acidemia combined with hyperhomocysteinemia: A case report
Authors: Pang Yunting , Meng Fanqing , Guo Yaqiu , Zhou Feng 
Published: September 2023

Key Clinical MessageMethylmalonic acidemia (MMA) combined with hyperhomocysteinemia is an autosomal recessive genetic disease which can lead to metabolic acidosis, elevated lactate, and high blood ammonia level. This anesthetic management was mainly how to maintain the stable state of perioperative physiological metabolism of such patients.
Endocardial pacing in a single‐ventricle patient with tricuspid atresia—a case report
Authors: Yamini‐Sharif Ahmad , Yaghoobian Ramin , Ghaderian Homa , Moosavi Najme‐Sadat 
Published: September 2023

Key Clinical MessageThe use of endocardial pacing in patients with univentricular hearts and intracardiac shunts is limited, primarily due to the increased risk of thromboembolism. However, when accompanied by proper long‐term anticoagulation therapy, it may be safer than epicardial interventions in selected patients at high risk for surgery.AbstractWe report transvenous endocardial pacing through the atrial septal defect in a patient with tricuspid atresia, transposition of the great arteries, severe pulmonary hypertension, and complete heart block. This study is among the first reported cases using this pacing method in a patient with a univentricular heart and intracardiac shunt.
Liquid‐Liquid Phase Equilibrium of Glycerolysis Precursors: Experimental and Modeling Study
Authors: Mamtani Kapil , da Silveira Christian L. , Farid Mohammed M. , Shahbaz Kaveh 
Published: September 2023

AbstractThe mutual immiscibility of glycerol and free fatty acids limits glycerolysis, a reaction capable of upgrading waste‐derived oils. In the present work, the liquid‐liquid phase equilibrium data for the glycerol‐water‐oleic acid and glycerol‐monoolein‐oleic acid ternary systems were determined experimentally and compared with predictions of the UNIFAC‐LLE and COSMO‐SAC models. Monoolein was found to affect the glycerol solubility in oleic acid strongly. None of the models investigated adequately determined phase equilibria for the glycerol‐monoolein‐oleic acid system. COSMO‐SAC predictions showed the best trend for glycerol solubility in the fatty phase. For the glycerol‐water‐oleic acid system, UNIFAC‐LLE predictions were in good agreement with experimental data.
Nickel‐Electrocatalyzed Synthesis of Bifuran‐Based Monomers
Authors: Oksanen Valtteri , Rautiainen Sari , Wirtanen Tom 
Published: September 2023

AbstractBifuran motifs can be accessed with nickel‐bipyridine electrocatalyzed homocouplings of bromine‐substituted methyl furancarboxylates, which, in turn, can be prepared from hemicellulose‐derived furfural. The described protocol uses sustainable carbon‐based graphite electrodes in the simplest setup – an undivided cell with constant current electrolysis. The reported method avoids using a sacrificial anode by employing triethanolamine as an electron donor.
Highly Electrophilic Intermediates in the Bypass Mechanism of Glutathione Peroxidase: Synthesis, Reactivity, and Structures of Selenocysteine‐Derived Cyclic Selenenyl Amides
Authors: Masuda Ryosuke , Karasaki Takafumi , Sase Shohei , Kuwano Satoru , Goto Kei 
Published: September 2023

AbstractSelenocysteine (Sec)‐derived cyclic selenenyl amides, formed by the intramolecular cyclization of Sec selenenic acids (Sec–SeOHs), have been postulated to function as protective forms in the bypass mechanism of glutathione peroxidase (GPx). However, their chemical properties have not been experimentally elucidated in proteins or small‐molecule systems. Recently, we reported the first nuclear magnetic resonance observation of Sec–SeOHs and their cyclization to the corresponding cyclic selenenyl amides by using selenopeptide model systems incorporated in a molecular cradle. Herein, we elucidate the structures and reactivities of Sec‐derived cyclic selenenyl amides. The crystal structures and reactions toward a cysteine thiol or a 1,3‐diketone‐type chemical probe indicated the highly electrophilic character of cyclic selenenyl amides. This suggests that they can serve not only as protective forms to suppress the inactivation of Sec–SeOHs in GPx but also as highly electrophilic intermediates in the reactions of selenoproteins.
DNA Chimeras as Electrochemical Biosensors for Host‐Guest Measurements in Blood
Authors: d'Astous Élodie V. , Dauphin‐Ducharme Philippe 
Published: September 2023

AbstractFew sensing platforms have become ubiquitous to enable rapid and convenient measurements at the point‐of‐care. Those, however, are “one‐off” technologies, meaning that they can only detect a single target and are hardly adaptable. In response, we plan to develop a sensing platform that can be extended to detect other classes of molecules and that affords rapid, convenient, continuous measurements directly in undiluted complex matrices. For this, we decided to rely on a host molecule that presents reversible interactions toward specific guest molecules to develop a new class of sensors that we coined “Electrochemical DNA‐host chimeras”. As a proof‐of‐concept for our sensor, we decided to use cyclobis(paraquat‐p‐phenylene) (“blue box”) that we attached on an electrode‐bound DNA to allow measurements of electron‐rich guests such as dopamine and aspirin. Doing so allows to promote host‐guest complex that could be quantified using blue box's electrochemistry. Because of this unique sensor architecture, we achieve, to our knowledge, the first reagentless, continuous and rapid (<5 min) host‐guest measurements in undiluted whole blood. We envision that given the library of electroactive host molecules that this will allow the development of a sensing platform for measurements of several classes of molecules in complex matrices at the point‐of‐care.
Color and luminance processing in V1 complex cells and artificial neural networks
Authors: Bun Luke M. , Horwitz Gregory D. 
Published: September 2023

AbstractObject recognition by natural and artificial visual systems benefits from the identification of object boundaries. A useful cue for the detection of object boundaries is the superposition of luminance and color edges. To gain insight into the suitability of this cue for object recognition, we examined convolutional neural network models that had been trained to recognize objects in natural images. We focused specifically on units in the second convolutional layer whose activations are invariant to the spatial phase of a sinusoidal grating. Some of these units were tuned for a nonlinear combination of color and luminance, which is broadly consistent with a role in object boundary detection. Others were tuned for luminance alone, but very few were tuned for color alone. A literature review reveals that V1 complex cells have a similar distribution of tuning. We speculate that this pattern of sensitivity provides an efficient basis for object recognition, perhaps by mitigating the effects of lighting on luminance contrast polarity. The absence of a contrast polarity‐invariant representation of color alone suggests that it is redundant with other representations.
Application of novel phytosorbent to sequester chromium(VI) and lead(II) from aqueous phase: Optimization, equilibrium and kinetics
Authors: Singh Mohini , Rayaz Mohd. , Rao Arti 
Published: September 2023

AbstractThis study investigates the potential of Prosopis cineraria leaf powder (PCLP) as a biosorbent for removing heavy metal ions (HMIs) from aqueous solutions. The biosorption characteristics of PCLP were evaluated with respect to pH, contact time, initial concentrations, and biosorbent dosage. Equilibrium data were analyzed using Langmuir, Freundlich, Temkin, and Dubinin‐Radushkevich (D‐R) isotherm models. Langmuir isotherm demonstrated monolayer adsorption for Cr(VI) (R2 = 0.9876) and Pb(II) (R2 = 0.9990), with maximum adsorption capacities of 10.046 and 10.238 mg g−1, respectively. Kinetic analysis showed a good fit to the pseudo‐second‐order (PSO) model, with R2 values of 0.9979 for Cr(VI) and 0.9821 for Pb(II), indicating that H‐bonding and electrostatic interactions were the dominant adsorption mechanisms. Additionally, non‐linear regression analysis was performed to determine the best‐fitting equilibrium model and compared with linear isotherm and kinetic models. The results confirmed that the nonlinear method outperformed the linear method in isotherm analysis. Specifically, the nonlinear Temkin isotherm model exhibited stronger correlation with the experimental data, making it the most suitable model for fitting the equilibrium data. Conversely, the non‐linear pseudo‐second‐order models yielded comparable goodness of fit to the linear kinetic analysis results. Overall, the findings highlight PCLP as a promising, environmentally friendly, and cost‐effective biosorbent for the removal of toxic HMIs, contributing to sustainable environmental management.
Networks of internationalizing digital platforms in physical place and digital space
Authors: Galkina Tamara , Atkova Irina , Ciulli Francesca 
Published: September 2023

AbstractResearch SummaryThe existing literature provides contradictory evidence on how digital platform firms establish network relations for internationalization. Some studies argue that they all but obviate the need for traditional relations in physical places. Others argue that these firms can suffer from overreliance on online interactions in digital space. We examine the coexistence of the network relations of international digital platform firms in physical place and digital space. Our multiple‐case study identifies three coexistence mechanisms: reinforcement, separation, and simulation. These mechanisms are conditioned by three respective modes of bordering between physical place and digital space: soldering, interosculation, and division. We contribute to the network approach to internationalization and formulate implications for the concepts of location and borders in international business.Managerial SummaryInternational digital platform firms establish traditional network relations in physical places and rely heavily on online interactions in digital space. However, how do they combine their networking activities in these two localities? We examine the coexistence of the network relations of international digital platform firms in physical place and digital space and identify three coexistence mechanisms: reinforcement, separation, and simulation. These mechanisms are conditioned by three respective modes of bordering between physical place and digital space: soldering, interosculation, and division. We show that international platform companies, despite being digital in nature, are well advised to pay attention to not only digital but also actual physical networking, and that they come to see these as mutually nurturing.
Number of positive lymph nodes is superior to neck stage of the 8th AJCC in predicting prognosis in parotid mucoepidermoid carcinoma
Authors: Li Wenlu , Yu Wenli , Cao Haifei , Zhang Aolin 
Published: September 2023

AbstractBackgroundTo clarify the impact of the number of positive lymph nodes (LNs) on the prognosis of parotid mucoepidermoid carcinoma (MEC).MethodsPatients who underwent neck dissection for parotid MEC were retrospectively enrolled. The primary outcome variable was overall survival (OS). Associations between OS and LN factors, including the AJCC N stage, intraparotid LN metastasis, number of positive LNs, LN size, and extranodal extension (ENE), were evaluated using Cox proportional hazard regression analyses.ResultsA total of 720 patients were included with a mean age of 56 ± 16 years. There was no additional survival compromise until two positive LNs were presented. After adjusting for the number of positive LNs, intraparotid LN metastasis, ENE, and LN size were not related to prognosis. Our proposed N stage based on the number of metastatic LNs (0/1 vs. 2–4 vs. 5+) showed a superior C‐index to the AJCC N stage in OS prediction.ConclusionQuantitative LN burden was an important determinant of prognosis, and the proposed N stage provided better OS stratification than the AJCC N stage.
A nationwide analysis of salvage surgery for laryngeal cancer in the elderly
Authors: Raad Richard A. , Holland Katie , Ritz Ethan M. , Tajudeen Bobby A. , Al‐Khudari Samer , Stenson Kerstin , Teitcher Joshua , Fidler Mary Jo , Jelinek Michael , Joshi Nikhil , Bhayani Mihir K. 
Published: September 2023

AbstractBackgroundWe aim to describe outcomes of elderly patients undergoing salvage surgery for laryngeal cancer and to characterize the interplay of age with various other factors in this growing population.MethodsUsing the National Cancer Database, we identified cases of salvage laryngectomy in patients who failed chemoradiation. An age cutoff of 70 years was used to separate subjects into two groups. Various factors were compared.ResultsOf the 825 patients included, 166 (20.1%) were elderly. Elderly patients had worse overall survival (p = 0.001), higher 30‐day and 90‐day mortality (p = 0.006, p < 0.001), and a longer length of stay (LOS) (p = 0.015). LOS over 1 week was associated with worse survival (p = 0.032).ConclusionElderly patients had worse overall perioperative survival than their younger counterparts. LOS and 30‐day readmissions were associated with higher risk of mortality in this group. We provide a contemporary set of relevant information for head and neck cancer providers to consider in this growing population
Effect of channel bed sediment on the transport behaviour of superparamagnetic silica encapsulated DNA microparticles in open channel injection experiments
Authors: Tang Yuchen , van Rhijn Fay , Abdelrady Ahmed , Foppen Jan Willem , Bogaard Thom 
Published: September 2023

AbstractRecently, superparamagnetic silica encapsulated DNA microparticles (SiDNAFe) were designed and in various experiments used as a hydrological tracer. We investigated the effect of bed characteristics on the transport behaviour and especially the mass loss of SiDNAFe in open channel injection experiments. Hereto, a series of laboratory injection experiments were conducted with four channel bed conditions (no sediment, fine river sediment, coarse sand, and goethite‐coated coarse sand) and two water qualities (tap water and Meuse water). Breakthrough curves (BTCs) were analysed and modelled. Mass loss of SiDNAFe was accounted for as a first‐order decay process included in a 1‐D advection and dispersion model with transient storage (OTIS). SiDNAFe BTCs could be adequately described by advection and dispersion with or without a first‐order decay process. SiDNAFe mass recoveries exhibited a wide range, varying from 50% to 120% from sediment‐free conditions to coarse (coated) sediment. In 6 out of 8 cases, SiDNAFe mass recovery was complete. Retention of SiDNAFe was 1–2 orders of magnitude greater than gravitational settling rates, as determined in Tang et al. (Hydrological Processes, e14801, 2023). We reason this was due to grain‐scale hyporheic flows and coupled water‐sediment‐particle interactions. The dispersive behaviour of SiDNAFe generally mimicked that of NaCl tracer. We concluded that SiDNAFe can be used in tracing experiments. However, water quality and sediment characteristics may affect the fate of SiDNAFe in river environments. SiDNAFe is a promising tool for particulate multi‐tracing in large rivers.
Safety and efficacy of mesenchymal stem cells in COVID‐19 patients: A systematic review and meta‐analysis
Authors: Yan Cai , Hu Minjie , Dai Rongjuan 
Published: September 2023

AbstractBackgroundCoronavirus disease‐19 (COVID‐19) is a zoonotic disease that has become a global pandemic. The fast evolution of the COVID‐19 pandemic and persist problems make COVID‐19 highly infectious; publicly accessible literature and other sources of information continue to expand in volume. The mesenchymal stem cells (MSCs) therapy efficacy for COVID‐19 is debatable.ObjectiveThis systematic review and meta‐analysis (SRMA) aimed to evaluate the usefulness of MSCs in treating COVID‐19.MethodsRelevant publications were retrieved from databases up to April 30, 2022. In the case of dichotomous data, the 95% confidence intervals (CIs) and pooled risk ratio (RR) were estimated with a random effects model (REM) or fixed effects model (FEM). The pooled mean difference (MD) and 95% CIs were calculated with REM or FEM in continuous data. In the outcomes, studies with insufficient or unusable data were reported descriptively.ResultsA total of eight randomized controlled trials (RCTs) with 464 people were chosen for this SRMA. Relative to the control group, mortality was significantly lower in the MSCs group (RR: 0.66, 95% CI: 0.44, 0.99, Z = 2.01, p = .04); other secondary outcomes, such as the clinical symptom improvement rate improved in the MSCs group (RR: 1.44, 95% CI: 1.05, 1.99, Z = 2.24, p = .03), clinical symptom improvement time (MD: −4.01, 95% CI: −6.33, −1.68, Z = 3.38, p = .0007), C‐reactive protein (CRP) (MD: −39.16, 95% CI: −44.39, −33.94, Z = 14.70, p < .00001) and days to hospital discharge (MD: −3.83, 95% CI: −6.19, −1.48, Z = 3.19, p = .001) reduced significantly in MSCs group. However, the adverse reaction incidence did not change significantly.ConclusionsMSCs are a viable therapy option for COVID‐19 because of their safety and potential efficacy. With no significant adverse effects, MSCs can reduce mortality, clinical symptom improvement time, and days to hospital discharge, improve clinical symptoms, and reduce inflammatory cytokines CRP in COVID‐19. However, further high‐quality clinical studies are required to confirm these results.
Cardiac troponin as a prognosticator of mortality in patients with sepsis: A systematic review and meta‐analysis
Authors: Zheng Peiqiu , Wang Xing , Guo Tao , Gao Wei , Huang Qiang , Yang Jie , Gao Hui , Liu Qian 
Published: September 2023

AbstractBackgroundThe impact of cardiac troponin on the short‐term and long‐term prognosis of patients with sepsis remains uncertain. Therefore, we conducted a meta‐analysis to investigate the role of cardiac troponin as a potential indicator for sepsis mortality.MethodsWe performed a comprehensive search for articles published before November 2022 using Google Scholar, PubMed, and Web of Science. Inclusion criteria for the studies were: (1) investigation of cardiac troponin, and (2) investigation of sepsis. Exclusion criteria included: (1) inability to obtain or calculate hazard ratio (HR) and 95% confidence interval (CI) for the relationship between cardiac troponin level and sepsis mortality, and (2) reviews, meta‐analyses, and case reports. Analysis of HRs and 95% CIs for the association between cardiac troponin level and sepsis mortality was conducted using STATA 12.0 software.ResultsOur study included 24 prospective studies (comprising 20,457 sepsis patients) and 4 retrospective studies (comprising 1416 sepsis patients). Meta‐analysis demonstrated that elevated cardiac troponin levels were significantly associated with increased sepsis mortality using a random effects model (HR = 1.57, 95% CI 1.41−1.75). Moreover, elevated cardiac troponin levels were also significantly associated with increased hospital mortality of sepsis (HR = 1.35, 95% CI 1.19−1.53) and long‐term mortality of sepsis (HR = 1.96, 95% CI 1.51−2.55) using the random effects model.ConclusionsOverall, our finding revealed that elevated cardiac troponin for sepsis patients was a predictor of hospital and long‐term mortality. Clinicians may treat septic patients with elevated cardiac troponin more cautious to avoid extra death. Moreover, large clinical studies are warranted to validate this association.