bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study
Authors: Rzepakowska Anna , Pietruszewska Wioletta , Żurek Michał , Molga-Magusiak Maria , Leszczyński Michał , Niemczyk Kazimierz 
Published: September 2023

Backgrounds
This study explored the contribution of peripheral blood markers in diagnosis and prognosis estimation of different stages of laryngeal dysplasia and early glottic cancer.

Methods
Retrospective analysis of clinical, histopathological and laboratory data of 220 patients including hemoglobin, neutrophil, lymphocyte, monocyte and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR).

Results
The mean hemoglobin level and platelets count showed differences between histopathological stages of lesions (p = 0.041 and 0.046, respectively). In patients with recurrent lesions mean level of lymphocyte count, NLR and PLR were significant in assessing progression and cancerization (p = 0.005, 0.028 and 0.023, respectively). The univariate analysis recognized level of PLR ≥ 141.74 as significant risk factor of the recurrence of vocal fold hypertrophic lesions (OR = 1.963).

Conclusions
The levels of blood cells and their ratios seem to be effective in predicting the recurrence of lesion and even more their potential role in indicating malignant progression.
Estimation of Runoff by SWAT Model in Noyyal River Basin
Authors: Revathi A. R. , Selvakumar S. , Ravikumar V. , Kannan Balaji , Raju M. 
Published: September 2023

Accurate assessment of water balance components holds paramount importance for the sustainable management of water resources in river basins. This study specifically concentrates on the application of the Soil and Water Assessment Tool (SWAT) model to evaluate water balance elements within the Noyyal River basin, a tributary of the Kaveri River originating from the Vellingiri hills in Western Tamil Nadu grapples with escalating water stress brought about by both anthropogenic activities and climatic fluctuations.
The methodology adopted encompasses the harmonious integration of diverse spatial and temporal datasets. These datasets are seamlessly incorporated within the confines of a Geographic Information System (GIS) framework. Through the process of watershed delineation 21 sub-basin was partitioned and which is further subdivided into 217 unique Hydrological Response Units (HRUs) are derived, each corresponding to a distinct hydrological reaction. The simulation employs 33 years of daily precipitation, coupled with minimum and maximum temperature records, enabling the continuous execution of the SWAT model for runoff prediction. The findings elucidate fluctuating runoff volumes over time, spanning from a minimum of 11.17 mm to a maximum of 610.32 mm. Notably, the annual average runoff stands at 206.7 mm, representing approximately 25.6% of the cumulative rainfall experienced within the Noyyal river basin.
Soil Application of Sea Weed Extract Granules and Foliar Application of Nano ZnO to Bt Hybrid Cotton to Vertic inceptisols
Authors: Raju Ambati Ravinder 
Published: September 2023

Bt hybrid cotton was significantly benefitted by the soil application of Sagarika sea weed extract granules at 25 kg ha-1 yr-1 along with the recommended basal fertilizers dose or foliar application of nano ZnO 4% at 0.04% at squaring and flowering stages. These treatments significantly enriched index leaf residual P and Zn content beyond 20 μg g-1 fresh weight during boll development stage and this resulted in significant improvement in lint yield by 7.5% i.e. 35 kg lint ha-1 yr-1, C:B ratio by 5.0% and net returns to the tune of ₹. 5000 ha-1 over alone 100% RDF in eroded Vertic inceptisols deficient in N, Mg, S, Zn and B. Excess rains at seedling and vegetative stage followed by drought at reproductive stages in both years, reduced the economic viability of seed treatment with bio-stimulants and foliar applications besides soil and foliar application of Zn, S, B alone or together to Bt hybrid cotton.
Exploring the Rotavirus Risk in Latin American Food and Water
Authors: Bourdett-Stanziola Lurys 
Published: September 2023

Rotavirus is considered a major public health problem worldwide because many children, adults, and animals die from gastroenteritis due to rotavirus; rotavirus contamination follows the fecal/oral route, and it is well supported that infection can also be achieved by consuming food and water that is contaminated with rotavirus. Research has shown that, in Latin American countries, unusual emerging strains of rotavirus are occurring in children and adults with gastroenteritis; which contain in their sequence genes from rotavirus genotypes detected in animals; Therefore, researchers consider it a virus with zoonotic potential.
In this review, I propose that rotavirus transmission occurs from wild animals, who use an intermediate host before contaminating humans, by means of the fecal/oral route, food, and water. Rotavirus produces genetic rearrangements generating new emerging strains, which are excreted into the environment. Generally, during the dry season in our Latin American countries, contaminated water is used to irrigate crops, and from there, much of this water ends up in the sea, where rotavirus is absorbed by filter-feeding molluscs, and from there, consumed by man and animals continuing its cycle.
Studies on the molecular characterization of rotavirus strains detected in food and water provide new insights into possible rotavirus genetic rearrangements and zoonoses. The emergence of strains derived from interspecies transmission has implicated and inspired the study of different vaccine strategies.
No net loss accounting: Aligning biodiversity offsets with ecosystem accounts
Authors: Czúcz Bálint , Simensen Trond , Skrindo Astrid Brekke , Rusch Graciela M. , Nybø Signe , Grainger Matthew , Töpper Joachim Paul 
Published: January 2025

Abstract

Biodiversity offsetting and ecosystem accounting are two rapidly developing fields that share a common goal: quantifying changes in ecosystems. Nevertheless, the intersection of these fields is often overlooked, despite the significant synergies they offer. This perspective paper explores this intersection from both sides, highlighting the benefits of ecosystem accounting for offsetting practice and the steps needed to make ecosystem accounts offsetting‐ready.

The System of Environmental‐Economic Accounting—Ecosystem Accounting (SEEA EA) is the most widespread and sophisticated framework for ecosystem accounting. This framework was designed to consistently quantify biodiversity changes at several spatial scales, including fine scales typically relevant for biodiversity offsetting. Furthermore, the components of this ecosystem accounting framework are also tightly related to the key concepts of biodiversity offsetting. To illustrate this, we provide a dictionary cross‐linking the terminologies of the two fields.

Despite the fundamental similarities, most ecosystem accounts developed today are not (directly) suitable for fine‐scale use. We discuss the reasons for this, and the practical challenges of improving the suitability of ecosystem accounts for offsetting use.

Solution: Aligning ecosystem accounts and biodiversity offsetting offers a huge opportunity for both fields, enhancing the standardisation of offsetting practices, and making them extensible to high level no net loss biodiversity targets. This can be achieved by using offsetting‐relevant scalable biodiversity metrics as condition variables, and by implementing condition indices that yield meaningful offsetting currencies. We argue that future ecosystem accounting case studies should recognise offsetting and the quantification of net loss/gain as relevant use cases. And we also call for dedicated offsetting pilots that apply ecosystem accounts in concrete no net loss contexts, highlighting the transformative potential of harnessing these synergies for biodiversity policy.
Rational Design of Single‐Atom Nanozymes for Combination Cancer Immunotherapy
Authors: Lin Hanchao , Gao Yonghui , Zhu Le , Guo Yu , Zhang Lumin , Xie Jiali , Yang Dongqin , Liu Jing , Dong Qiongzhu , Zhu Zhiling 
Published: January 2025

AbstractRemodeling of the tumor immune microenvironment and enhancement of antitumor immune responses are necessary to overcome immunotherapy resistance in tumors. However, tumor heterogeneity and complexity of immune evasion mechanisms pose significant therapeutic challenges. Nanozymes exhibit enzyme‐like characteristics and unique nanomaterial properties, showing potential for tumor therapy. However, design of effective nanozymes remains complex, inefficient, and functionally limited. Therefore, in this study, a novel strategy combining rationally designed single‐atom nanozymes (SAzymes) with immune checkpoint blockade (ICB) therapy is established. Molybdenum SAzymes supported on graphitic carbon nitride (Mo SAs) are constructed using 25 transition metal candidates from the 4th to 6th periods based on high‐throughput calculations and optimal piezoelectric‐enhanced multienzyme‐like activities. Upon activation by ultrasound, Mo SAs exerted potent therapeutic effects against ICB‐resistant tumors and remodeled the tumor immune microenvironment by inducing tumor immunogenic cell death, alleviating tumor hypoxia, and modulating chemokine expression in tumors. Combination of Mo SAs with anti‐programmed death protein‐1 antibodies further enhanced their antitumor efficacy, highlighting their potential to treat ICB‐resistant tumors.
Controlling of Circularly Polarized Luminescence via Modulating the Angle Between Transition Electric and Magnetic Dipole Moments
Authors: Yuan Li , Mao Dan , Yan Zhi‐Ping , Hu Jia‐Jun , Ni Hua‐Xiu , Hong Xian‐Fang , Zuo Jing‐Lin , Zheng You‐Xuan 
Published: January 2025

AbstractThe most challenging task in the development of chiral luminescent materials is currently increasing the dissymmetry factors (gPL, gEL) of circularly polarized luminescence (CPL). Current research primarily focuses on enhancing the molecular transition magnetic dipole moment, while the angle between the transition electric and magnetic dipole moment (θe,m) has received comparatively limited attention. In this study, two pairs of intrinsically axial chiral fluorescence (CP‐MR‐F) and thermally activated delayed fluorescence (CP‐MR‐TADF) enantiomers (R/S‐BBCz‐BN and R/S‐OBBCz‐BN) with increased g factors by modulating θe,m are reported. Based on R/S‐5H,5′H ‐6,6′‐bibenzo[b]carbazole units, the theoretically calculated θe,m and gcal for S‐BBCz‐BN are 17.7° and 1.1 × 10−2, respectively, enabling excellent CPL properties with |gPL| of 5.8 × 10−3 in toluene, representing one of the highest g values among MR materials. By employing the less conjugated R/S‐7,7′,8,8′,9,9′,10,10′‐octahydro‐5H,5′H‐6,6′‐bibenzo[b]carbazole groups with better electron donating ability, R/S‐OBBCz‐BN demonstrate good MR‐TADF and CPL properties with a peak at 467 nm, a full width at half‐maximum of 27 nm, and |gPL| of 2.5 × 10−3. Furthermore, the optimized circularly polarized organic light‐emitting diodes based on these two pairs of enantiomers showcase high maximum external quantum efficiencies of 24.7%/33.3% and mirror symmetrical circularly polarized electroluminescence with |gEL| factors of 3.4/1.2 × 10−3, respectively.
Nature Inspired Phototropic Artificial Photosynthesis
Authors: Zhang Jiaqi , Fang Tao , Chen Tingting , Yin Taishan , Zhao Yuqing , Cao Wenhan , Pang Huan , Huang Zhongjie 
Published: January 2025

AbstractThe efficiency of solar energy capture by terrestrial and solar device surfaces is significantly influenced by the variations in the solar angle of incidence, which change with latitude, season, and time of day. These fluctuations result in notable energy density losses. Photoelectrochemical (PEC) system‐based artificial leaf device has attracted immense research interests recently. However, its programmability and adaptiveness is highly desired and noticeably lacking. In this study, a novel programmable biomimetic PEC system—artificial aquatic plant—designed for bias‐free complete water splitting, capable of adapting is introduce to dynamic light incident angles. Inspired by key structures in aquatic plants, such as cytoplasm, chloroplasts, and petioles, this work incorporates innovative design with light‐weight PEC electrodes, protective hydrogel layers, integrated with light‐responsive hydrogel composites as supportive and actuating elements. As a result, this advanced device not only maintains stable complete water splitting performance but also exhibits characteristic phototropic properties, enhancing water splitting efficiency by 47% and 866% under light incident at 45° and 90°. Unlike traditional rigid systems, this work opens new avenues for the development of intelligent and programmable solar devices that can adapt to varying environments, paving the way for adaptive green energy technology and self‐sustaining energy production.
A Close Look at the Local Structure of Functional Polymers: The Example of Poly(Vinylidene Fluoride)
Authors: Kantrow Henry J. , Welton Claire , Thomas Neethu , Sarou‐Kanian Vincent , Pawlak Tomasz , Stingelin Natalie , Reddy G. N. Manjunatha 
Published: January 2025

AbstractFunctional macromolecular materials promise to enable important improvements in many aspects of everyday life, including for energy applications, novel electronics systems, or wearable health care products. In contrast to widely‐used commodity plastics such as polyolefins, polyamides, or polyesters, it, however, remains challenging to advance detailed insights into the interrelation of structure and performance for functional polymers, limiting progress. The reason is that the macroscopic properties of such polymers often depend on local chain arrangements rather than long‐range order only. Here, it is demonstrated on the example of the well‐investigated ferroelectric poly(vinylidene fluoride) (PVDF) that modern nuclear magnetic resonance (NMR) spectroscopy enables the quantitative analysis of the complex solid‐state structure of this polymer, providing unprecedented insight. The precise fractions of chain segments of different conformations are revealed, as well as their spatial distributions with respect to each other. Thereby, a significant population of short‐range ordered chain segments is identified, a large fraction of which in close proximity to defects and disordered segments. Unsurprisingly, different environments lead to different structural dynamics — collectively showing that characterizing local order/disorder and their dynamics is imperative to accurately describe the properties of functional polymers such as PVDF.
A Versatile Self‐Templating Approach for Constructing Ternary Halide Perovskite Heterojunctions to Achieve Concurrent Enhancement in Photocatalytic CO2 Reduction Activity and Stability
Authors: Zhang Meng‐Ran , Feng You‐Xiang , Liu Zhao‐Lei , Su Ke , Yuan Su‐Xian , Zhang Min , Lu Tong‐Bu 
Published: January 2025

AbstractMetal halide perovskite (MHP)‐based photocatalysts encounter significant stability challenges in water‐containing systems, posing a major obstacle to their application in artificial photosynthesis. Herein, an innovative and universal strategy is present to create MHP‐based ternary heterojunctions based on a self‐templating method. A series of composite catalysts featuring sandwich hollow structures are constructed, with MHPs such as CsPbBr3, Cs3Bi2I9, Cs3Sb2Br9, and Cs2AgBiBr6 serving as the intermediate layers. The unique sandwich structure effectively shields MHPs from direct water contact, allowing MHP‐based photocatalysts to exhibit exceptional stability in water‐containing photocatalytic environments for durations exceeding 200 h. Furthermore, the hollow design ensures complete contact between the reaction substrates with both the oxidation and reduction functional areas. Compared to single perovskite materials, MHP‐based ternary heterojunction photocatalysts exhibit stronger oxidation capability and improved charge separation efficiency, leading to a substantial enhancement in photocatalytic CO2 reduction performance. Notably, the ternary heterojunction with CsPbBr3 as the intermediate layer achieves an electron consumption rate of up to 1824 µmol g−1 h−1 for CO2 reduction, which is far superior to other reported MHP‐based catalysts under similar conditions. This study provides a potent strategy for simultaneously enhancing the stability and activity of MHP‐based photocatalysts, paving the way for their potential applications in artificial photosynthesis.
Electrolyte Engineering with Asymmetric Spatial Shielding Effect for Aqueous Zinc Batteries
Authors: Cong Jianlong , Hu Zuyang , Hu Le , Li Tongjiang , Ji Haijin , Long Zihan , Fan Yuxin , Wen Zhipeng , Lin Yu‐Chang , Xu Henghui , Li Zhen , Li Shunning , Pan Feng , Huang Yunhui 
Published: January 2025

AbstractThe electrochemical instability of electrode/electrolyte interface and aqueous electrolyte collectively brings technical barriers, such as side reactions like hydrogen evolution and corrosion, as well as zinc dendrites, which hinder the practical application of aqueous zinc batteries. Here, an electrolyte engineering strategy is proposed with asymmetric spatial shielding effect by employing the molecules with asymmetric spatial structure as a cosolvent. Such molecule contains small methyl group and large cyclopentyl group to balance migration capability and shielding volume, which can not only promote the solvation structure of Zn2+ containing more anions and solid electrolyte interface derived from abundant anions but also rapidly and effectively adsorb on the surface of Zn anode to remodel the electric double layer. This strategy alleviates hydrogen evolution and corrosion while achieving dendrite‐free Zn deposition. Consequently, the Zn/I2 cell can operate stably at 2 A g−1 for 30 000 cycles over 180 days, with a capacity retention of 79.8%. Despite featuring a cathode areal capacity of 4.74 mAh cm−2 and an N/P ratio of 2.5, the Zn/NH4V4O10 cell still achieves an impressive capacity retention of 88.8% at 0.5 A g−1 for 200 cycles, demonstrating a significant potential for practical application.
A Bioengineered Model of the Human Cornea for Preclinical Assessment of Human Ocular Exposure to Environmental Toxicants
Authors: Kim Se‐jeong , Guo Ning , Tan Zong Yao , Gao Xing , Fattahi Pouria , Liu Haijiao , Chang Jeehan , Younesi Mousa , Jung Selice , Chung Yewhan , Song Minkyung , Jung Michelle , Huh Dan Dongeun 
Published: January 2025

AbstractHere a bioengineered platform is introduced to investigate adverse effects of environmental materials on the human cornea. Using primary cells, this system is capable of reproducing the differentiated corneal epithelium and its underlying stroma in the human eye, which can then be treated with externally applied solid, liquid, or gaseous substances in a controlled manner and under physiologically relevant conditions. The proof‐of‐principle of how this system can be used to simulate human ocular exposure to different classes of environmental toxicants for direct visualization and quantitative analysis of their potential to induce acute corneal injury and inflammation is demonstrated. This model can also be further engineered to create an electromechanically actuated array of multiple human corneal tissues that can emulate spontaneous eye blinking. Using this advanced system, it is shown that blinking‐like mechanical motions may play a protective role against adverse effects of environmental toxicants. This work yields an immediately deployable in vitro technology for screening ocular toxicity of existing and emerging environmental materials of various types and may enable the development of more realistic, human‐relevant preclinical toxicology models complementary to traditional animal testing.
Masquelet Inspired in Vivo Engineered Extracellular Matrix as Functional Periosteum for Bone Defect Repair and Reconstruction
Authors: Jiang Chen , Miao Tianfeng , Xing Xiaojie , Schilling Kevin J. , Lenhard Nicholas , Wang Lichen , McDowell Susan , Nilsson Bradley L. , Wang Hongjun , Zhang Xinping 
Published: January 2025

AbstractThe Masquelet technique that combines a foreign body reaction (FBR)‐induced vascularized tissue membrane with staged bone grafting for reconstruction of segmental bone defect has gained wide attention in Orthopedic surgery. The success of Masquelet hinges on its ability to promote formation of a “periosteum‐like” FBR‐induced membrane at the bone defect site. Inspired by Masquelet's technique, here a novel approach is devised to create periosteum mimetics from decellularized extracellular matrix (dECM), engineered in vivo through FBR, for reconstruction of segmental bone defects. The approach involved 3D printing of polylactic acid (PLA) template with desired pattern/architecture, followed by subcutaneous implantation of the template to form tissue, and depolymerization and decellularization to generate dECM with interconnected channels. The dECM matrices produces from the same mice (autologous) or from different mice (allogenic) are used as a functional periosteum for repair of structural bone allograft in a murine segmental bone defect model. This study shows that autologous dECM performed better than allogenic dECM, further permitting local delivery of low dose BMP‐2 to enhance allograft incorporation. The success of this current approach can establish a new line of versatile, patient‐specific, and periosteum‐like autologous dECM for bone regeneration, offering personalized therapeutics to patients with impaired healing.
Microenvironment Mechanical Torque from ZnFe2O4 (ZFO) Micromotors Inhibiting Tumor Migration
Authors: Jiang Tingting , Feng Ye , Gao Chao , Jiang Jiamiao , Chen Bin , Liu Suyi , Du Dailing , Ding Miaomiao , Rong Jinghui , Liao Zongzhen , Li Wensheng , Wilson Daniela A. , Tu Yingfeng , Song Shuqin , Wang Yi , Peng Fei 
Published: January 2025

AbstractMechanical force attracts booming attention with the potential to tune the tumor cell behavior, especially in cell migration. However, the current approach for introducing mechanical input is difficult to apply in vivo. How the mechanical force affects cell behavior in situ also remains unclear. In this work, an intelligent miniaturized platform is constructed with magnetic ZnFe2O4 (ZFO) micromotors. The wireless ZFO can self‐assemble in situ and rotate to generate mechanical torque of biologically relevant piconewton‐scale at the target tumor site. It is observed unexpectedly that enhanced in situ mechanical rotating torque from ZFO micromotors and the active fluid inhibit the migration of highly invasive A549 tumor cells. The down‐regulation of the Piezo1 channel and the suppressed signaling of ROCK1 in mechano‐adaptive tumor cells is found to be related to the inhibition effect. With effectiveness confirmed with the zebrafish xenograft model, this platform provides a valuable toolkit for mechanobiology and force‐associated non‐invasive tumor therapy.