bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Caregivers' awareness matters’: Call for a child‐centred approach to early detection of autism spectrum disorder through well‐child visits in Japan
Authors: Horiuchi Sayaka , Nomura Osamu , Curry Leslie , Kushima Megumi , Arnold Linda , Yamagata Zentaro 
Published: February 2023

AbstractBackgroundEarly detection of autism spectrum disorder (ASD) is essential to provide children with timely treatment and support. Evidence‐based screening measures make it possible to identify children with suspected ASD at an early stage. Although Japan has a universal healthcare system that covers well‐child visits, detection rates of developmental disorders, including ASD, at 18 months vary widely between municipalities (0.2%–48.0%). The reasons for this high level of variation are poorly understood. The present study aims to describe the barriers and facilitators of incorporating ASD identification during well‐child visits in Japan.MethodsThis is a qualitative study that conducts semi‐structured in‐depth interviews in two municipalities of Yamanashi Prefecture. We recruited all public health nurses (n = 17) and paediatricians (n = 11) involved in the well‐child visit in each municipality and caregivers of children who also participated in the visits during the study period (n = 21).ResultsWe identified four themes characterizing the process of ASD identification in the target municipalities: (1) Identification of children with ASD is driven by caregivers' sense of concern, acceptance and awareness. (2) Multidisciplinary cooperation and shared decision‐making is limited. (3) Skills and training for developmental disabilities screening are underdeveloped. (4) Caregivers' expectations shape the interaction in important ways.ConclusionsNon‐standardization of screening methods, limited knowledge and skills on screening and child development among healthcare providers and poor coordination among healthcare providers and caregivers are the main barriers to effective early detection of ASD through well‐child visits. The findings suggest the importance of promoting a child‐centred care approach through the application of evidence‐based screening measures and effective information sharing.
Longitudinal links between maternal cultural socialization, peer ethnic‐racial discrimination, and ethnic‐racial pride in Mexican American youth
Authors: Stein Gabriela Livas , Christophe N. Keita , Castro‐Schilo Laura , Gomez Alvarado Casandra , Robins Richard 
Published: February 2023

AbstractThis paper used cross‐lagged panel models to test the longitudinal interplay between maternal cultural socialization, peer ethnic‐racial discrimination, and ethnic‐racial pride across 5th to 11th grade among Mexican American youth (N = 674, Mage = 10.86; 72% born in the United States; 50% girls; Wave 1 collected 2006–2008). Maternal cultural socialization predicted increases in subsequent youth ethnic‐racial pride, and youth ethnic‐racial pride prompted greater maternal cultural socialization. However, peer ethnic‐racial discrimination was associated with subsequent decreases in ethnic‐racial pride. The magnitude of these associations was consistent across 5th to 11th grades suggesting that maternal cultural socialization messages are necessary to maintain ethnic‐racial pride across adolescence, thus families must continually support the development of ethnic‐racial pride in their youth to counter the effects of discrimination.
Family engagement during the COVID‐19 pandemic: Opportunities and challenges for school social work
Authors: Sugrue Erin , Ball Annahita , Harrell Danielle R. , Daftary Ashley‐Marie H. 
Published: February 2023

AbstractThe COVID‐19 pandemic brought dramatic changes in schooling in the United States and across the world, including abrupt shifts to remote learning, immediate cessation of social contact, intensive family engagement in education and diminished school capacity for social–emotional supports. While the initial national lockdown was temporary, the long‐lasting effects of the pandemic on society are still being revealed. This study contributes to a growing body of research exploring and documenting shifts in school social work practice in the United States during the COVID era. We used qualitative methods to explore how school social workers (SSWers) practised family engagement during the pandemic and their perceptions of the benefits and challenges of increased family engagement. Analysis of interviews with 20 SSWers from three US states (Colorado, Minnesota and Nevada) revealed five primary themes: reasons for family engagement, ways of engaging with families, frequency of family contact, challenges in engaging families and SSWers' attitudes and perceptions about family engagement. Results indicated a need for a comprehensive, organized and strategic family engagement plan in schools as we move into the post‐acute phases of the pandemic. Future research should explore how SSWers may serve as leaders in the development of such plans and how interprofessional practice might advance this agenda further.
Variants of LRP2, encoding a multifunctional cell‐surface endocytic receptor, associated with hearing loss and retinal dystrophy
Authors: Faridi Rabia , Yousaf Rizwan , Gu Shoujun , Inagaki Sayaka , Turriff Amy E. , Pelstring Keith , Guan Bin , Naik Amelia , Griffith Andrew J. , Adadey Samuel Mawuli , Aboagye Elvis Twumasi , Awandare Gordon A. , Morell Robert J. , Tsilou Ekaterini , Noyes Amanda G. , Sulmonte Laura A. G. , Wonkam Ambroise , Schrauwen Isabelle , Leal Suzanne M. , Azaiez Hela , Brewer Carmen C. , Riazuddin Sheikh , Hufnagel Robert B. , Hoa Michael , Zein Wadih M. , de Dios J. Karl , Friedman Thomas B. 
Published: February 2023

AbstractHereditary deafness and retinal dystrophy are each genetically heterogenous and clinically variable. Three small unrelated families segregating the combination of deafness and retinal dystrophy were studied by exome sequencing (ES). The proband of Family 1 was found to be compound heterozygous for NM_004525.3: LRP2: c.5005A > G, p.(Asn1669Asp) and c.149C > G, p.(Thr50Ser). In Family 2, two sisters were found to be compound heterozygous for LRP2 variants, p.(Tyr3933Cys) and an experimentally confirmed c.7715 + 3A > T consensus splice‐altering variant. In Family 3, the proband is compound heterozygous for a consensus donor splice site variant LRP2: c.8452_8452 + 1del and p.(Cys3150Tyr). In mouse cochlea, Lrp2 is expressed abundantly in the stria vascularis marginal cells demonstrated by smFISH, single‐cell and single‐nucleus RNAseq, suggesting that a deficiency of LRP2 may compromise the endocochlear potential, which is required for hearing. LRP2 variants have been associated with Donnai–Barrow syndrome and other multisystem pleiotropic phenotypes different from the phenotypes of the four cases reported herein. Our data expand the phenotypic spectrum associated with pathogenic variants in LRP2 warranting their consideration in individuals with a combination of hereditary hearing loss and retinal dystrophy.
An early experience in robotic ileoanal pouch surgery with robotic intracorporeal single‐stapled anastomosis (RiSSA) at a tertiary referral centre
Authors: Deputy Mohammed , Pitman Francesca , Sahnan Kapil , Miskovic Danilo , Faiz Omar 
Published: February 2023

AbstractAimA robotic approach to ileal pouch–anal anastomosis (IPAA) surgery offers advantages over other approaches in terms of precision, improved access to the pelvis and less muscular fatigue for the surgeon. The integrity of the anastomosis is also fundamental to successful IPAA surgery. The robotic platform can permit intracorporeal suturing deep within the pelvis to create a single‐stapled, double purse‐string anastomosis, which may reduce the risk of anastomotic complications. This study describes the safety and early outcomes of robotic intracorporeal single‐stapled anastomosis (RiSSA) amongst patients operated consecutively at a tertiary centre immediately before and following the pandemic.MethodA retrospective study of prospectively collected data analysing the outcome of patients undergoing robotic IPAA between 2019 and 2022 was conducted. All procedures were performed with the da Vinci Xi Surgical System (with a hand‐assisted suprapubic incision to fashion the pouch). All pouch–anal anastomoses were performed using a double purse‐string, single‐stapled (RiSSA) method. Demographic, clinical and outcome data were collected.ResultsTwenty consecutive patients (nine with ulcerative colitis and 11 with familial adenomatous polyposis) were included with a median age of 25 years (range 16–52); 18 had American Society of Anesthesiologists classification II, and mean body mass index was 24 kg/m2 (range 18.1–34.3). Nine patients (eight ulcerative colitis and one familial adenomatous polyposis) had undergone prior subtotal colectomy and therefore underwent restorative proctectomy with IPAA. Eleven patients underwent restorative proctocolectomy. All procedures were completed robotically. The median length of stay was 9 days (5–49). There were no unplanned admissions to intensive care and no deaths. Three patients were readmitted following hospital discharge for (i) an ileus managed conservatively, (ii) small bowel obstruction managed conservatively and (iii) small bowel obstruction due to constriction at the stoma site necessitating surgery. There were two additional reoperations both for drain complications, one for drain removal and one for drain erosion. On mobilization of the pouch in the latter case, an anastomotic defect was observed. In total, 19/20 patients underwent RiSSA without postoperative anastomotic problems.DiscussionRiSSA offers a safe and feasible alternative technique to other minimally invasive approaches with low rates of anastomosis‐related complications.
Bildgestützte Beurteilung des Ansprechens auf Immuntherapien bei Hauttumoren
Authors: Mayer Kristine E. , Gaa Jochen , Biedermann Tilo , Posch Christian 
Published: February 2023

ZusammenfassungImmuncheckpoint‐Inhibitoren und weitere immuntherapeutische Behandlungsansätze haben die Therapieoptionen beim Melanom und anderen Hauttumoren im letzten Jahrzehnt erheblich erweitert. Die breite Anwendung von Immuntherapien erfordert geeignete Methoden zur Überwachung des Krankheitsverlaufs während der Therapie. Immuntherapien beruhen auf einer gezielten Modulation des Immunsystems. Diese führt zu komplexen klinischen Reaktionsmustern wie der Pseudoprogression, die eine Anpassung der konventionellen diagnostischen Bildgebungsmethoden oder die Einführung neuer Technologien erfordern. In dieser Übersichtsarbeit werden die derzeit verfügbaren nichtinvasiven bildgebenden Verfahren zur Beurteilung des Ansprechens auf Immuntherapien bei Hauttumoren mit Vor‐ und Nachteilen dargestellt. Außerdem werden vielversprechende zukünftige Alternativen aufgezeigt, die die neuartigen Anforderungen bei Immuntherapien besonders berücksichtigen sollen.
Diagnose und chirurgische Behandlung gutartiger Tumoren der Nägel
Authors: Starace Michela , Rubin Adam I. , Di Chiacchio Nilton Gioia , Pampaloni Francesca , Alessandrini Aurora , Piraccini Bianca Maria , Iorizzo Matilde 
Published: February 2023

ZusammenfassungEs ist wenig über gutartige nicht‐melanozytäre Nageltumoren bekannt. Grund dafür ist wahrscheinlich ihre niedrige Pathogenität. Sie werden häufig als entzündliche oder infektiöse Erkrankungen fehldiagnostiziert. Je nach Art des Tumors und seiner Lokalisation im Nagelapparat haben sie verschiedene Merkmale. Typische Zeichen eines Tumors sind eine Raumforderung und/oder sekundäre Nagelveränderungen, die aus den beschädigten Nagelstrukturen hervorgehen. Insbesondere wenn ein einziger Finger oder eine einzige Zehe Dystrophie aufweist oder ein Symptom ohne weitere Erklärung genannt wird, ist das Vorliegen eines Tumors immer auszuschließen. Eine dermatoskopische Untersuchung kann die Visualisierung der Erkrankung verbessern und unterstützt in vielen Fällen die Diagnose. Sie kann auch bei der Identifizierung der richtigen Stelle für eine Biopsie helfen, aber einen chirurgischen Eingriff nicht ersetzen.In diesem Artikel werden die häufigsten nicht‐melanozytären Tumoren analysiert, einschließlich Glomustumor, Exostose, myxoide Pseudozyste, erworbenes Fibrokeratom, Onychopapillom, Onychomatrikom, superfizielles akrales Fibromyxom und subunguales Keratoakanthom.Ziel unserer Studie ist es, die wesentlichen klinischen und dermatoskopischen Eigenschaften der häufigsten gutartigen nicht‐melanozytären Nageltumoren zu überprüfen und mit der Histopathologie zu korrelieren sowie Ärzte hinsichtlich der besten chirurgischen Versorgung zu beraten.
Surgical lymphology. Therapy option for lymphoedema and lipohyperplasia dolorosa
Authors: Cornely Manuel E. 
Published: February 2023

SummaryThe typical therapy in lymphology is conservative. However, reconstructive and resective treatments for primary and secondary lymphoedema as well as resective procedures for lipohyperplasia dolorosa (LiDo) “lipedema” have been available for several decades. Each of these procedures has its clear indication and decades of successful history. These therapies represent a paradigm shift in lymphology. In reconstruction, the basic idea is to restore lymph flow, to bypass the obstacle to drainage in the vascular system. The combination procedures of two‐stage application of resection and reconstruction in lymphoedema are just as much a “work in progress” as the concept of prophylactic lymphatic venous anastomosis (LVA).In the case of resective procedures, the focus is not only on improving the silhouette, but also on reducing the complex decongestion therapy (CDT) and – in the case of LiDo – freedom from pain by improving imaging procedures and the early use of surgical therapy options, the development of higher stages of lymphoedema should be a thing of the past. For LiDo, the application of surgical procedures avoids lifelong CDT and achieves painlessness. All surgical procedures, but especially the resection procedures, are now possible in a way that is gentle on the lymphatic vessels and should be offered to patients with lymphoedema or lipohyperplasia dolorosa without reservation if the goals – reduction in circumference, avoidance of lifelong CDT and, in the case of LiDo, painlessness – cannot be achieved by other means.
Experimental evidence of size‐selective harvest and environmental stochasticity effects on population demography, fluctuations and non‐linearity
Authors: Rogers Luke A. , Moore Zachary , Daigle Abby , Luijckx Pepijn , Krkošek Martin 
Published: February 2023

AbstractTheory and analyses of fisheries data sets indicate that harvesting can alter population structure and destabilise non‐linear processes, which increases population fluctuations. We conducted a factorial experiment on the population dynamics ofDaphnia magnain relation to size‐selective harvesting and stochasticity of food supply. Harvesting and stochasticity treatments both increased population fluctuations. Timeseries analysis indicated that fluctuations in control populations were non‐linear, and non‐linearity increased substantially in response to harvesting. Both harvesting and stochasticity induced population juvenescence, but harvesting did so via the depletion of adults, whereas stochasticity increased the abundance of juveniles. A fitted fisheries model indicated that harvesting shifted populations towards higher reproductive rates and larger‐magnitude damped oscillations that amplify demographic noise. These findings provide experimental evidence that harvesting increases the non‐linearity of population fluctuations and that both harvesting and stochasticity increase population variability and juvenescence.
Cheating Detection of Test Collusion: A Study on Machine Learning Techniques and Feature Representation
Authors: Chang Shun‐Chuan , Chang Keng Lun 
Published: February 2023

AbstractMachine learning has evolved and expanded as an interdisciplinary research method for educational sciences. However, cheating detection of test collusion among multiple examinees or sets of examinees with unusual answer patterns using machine learning techniques has remained relatively unexplored. This study investigates collusion on multiple‐choice tests by introducing feature representation methodologies and machine learning algorithms that can be jointly used as a promising method; they can be used not only to detect individual examinees involved in the collusion but also to evaluate test collusion with or without the groups of potentially dishonest examinees identified a priori. Furthermore, using small‐sample examples, the visual detection procedures of the current study were articulated to help identify questionable item response groups and simultaneously focus on the specific individuals providing anomalous answers.
Migraine and thyroid dysfunction: Co‐occurrence, shared genes and biological mechanisms
Authors: Tasnim Sana , Nyholt Dale R. 
Published: February 2023

AbstractBackground and purposeMigraine and thyroid dysfunction, particularly hypothyroidism, are common medical conditions and are known to have high heritability. Thyroid function measures, thyroid stimulating hormone (TSH) and free thyroxine (fT4), are also known to be genetically influenced. Although observational epidemiological studies report an increased co‐occurrence of migraine and thyroid dysfunction, a clear and combined interpretation of the findings is currently lacking. A narrative review is provided of the epidemiological and genetic association evidence linking migraine, hypothyroidism, hyperthyroidism and thyroid hormones TSH and fT4.MethodsAn extensive literature search was conducted in the PubMed database for epidemiological, candidate gene and genome‐wide association studies using the terms migraine, headache, thyroid hormones, TSH, fT4, thyroid function, hypothyroidism and hyperthyroidism.ResultsEpidemiological studies suggest a bidirectional relationship between migraine and thyroid dysfunction. However, the nature of the relationship remains unclear, with some studies suggesting migraine increases the risk for thyroid dysfunction whilst other studies suggest the reverse. Early candidate gene studies have provided nominal evidence for MTHFR and APOE, whilst more recently genome‐wide association studies have provided robust evidence for THADA and ITPK1 being associated with both migraine and thyroid dysfunction.ConclusionsThese genetic associations improve our understanding of the genetic relationship between migraine and thyroid dysfunction, provide an opportunity to develop biomarkers to identify migraine patients most likely to benefit from thyroid hormone therapy, and indicate that further cross‐trait genetic studies have excellent potential to provide biological insight into their relationship and inform clinical interventions.
Father involvement during early childhood: A systematic review of qualitative studies
Authors: Diniz Eva , Brandão Tânia , Veríssimo Manuela 
Published: February 2023

AbstractObjectiveIn this research, we analyze and integrate the qualitative empirical studies of father involvement, specifically examining his involvement in the multiple functions and dimensions of care during early childhood.BackgroundFather involvement is a relevant social and scientific topic given the changes in fathers' role in contemporary families. Fatherhood involving presence, affection, support, nurturance, as well as prioritizing child's needs, seems to be a perspective dominantly shared by parents. However, studies tend to focus on intact White middle‐class families, neglecting other backgrounds and family configurations, which may be easily examined through qualitative approaches.MethodA database search was performed using a combination of relevant keywords in the title, abstract, and keywords.ResultsInitially, 1,102 records were identified, with 58 manuscripts being assessed for eligibility. Finally, 16 articles were included. The analysis of the corpus identified three main themes: (a) the definition of father involvement and the description of main dimensions in which he was involved, (b) main challenges and facilitators of father involvement, and (c) the influence of intergenerational values on it.ConclusionsFindings provide insights about the multiple dimensions and roles related to father involvement, and they open new avenues for future research.ImplicationsThe results reflected the state of the art about father involvement in qualitative research. Suggestions are made to reinforce fathers' full involvement in childcare, at personal and social levels.
Microstructural evolution and mechanical characterization for the AlCoCrFeNi2.1 eutectic high‐entropy alloy under different temperatures
Authors: Li Yafei , Zhou Jiahe , Liu Yifei , Lu Chuanyang , Shi Lei , Zheng Wenjian , Jin Weiya , Gao Zengliang , Yang Jianguo , He Yanming 
Published: February 2023

AbstractRecently, there has been a lot of interest in the AlCoCrFeNi2.1 eutectic high‐entropy alloys (EHEAs), which can achieve a good balance of strength and ductility. The relationship between the microstructure and mechanical properties of the alloy was established in this study by examining the microstructural evolution during heat treatment of 500–1000°C. The results show that the alloy's microstructure remained unchanged when the heat treatment temperature was lower than 700°C. With further rise above 800°C, the B2II precipitates were inspected in the L12 matrix. Besides, L12II started to be precipitated from the B2 matrix at 900°C. The tensile test results conducted at 20–1000°C showed that both the yield strength and ultimate tensile strength decreased as the temperature rose. As for the elongation, however, it increased dramatically when the testing temperature was over 800°C, being attributed to the dynamic recrystallization. The results obtained provided a fundamental understanding of high‐temperature properties for duplex HEAs.
A novel test specimen for mixed mode I/II/III fracture study in brittle materials
Authors: Jalayer Reza , Saboori Behnam , Ayatollahi Majid Reza 
Published: February 2023

AbstractA new test specimen is proposed for investigation of mixed mode I/II/III fracture of materials. In the test specimen, by displacing the position of an inclined crack from the middle of the rectangular specimen, in addition to mode II loading, mixed mode I/III loading conditions are created under anti‐symmetric four‐point bending. To examine the applicability of the test set‐up, the specimens made of PMMA (polymethyl‐methacrylate) with three crack angles and three different positions of crack with reference to the middle of the specimen are tested. The experimental fracture loads are compared with the theoretical predictions of the maximum principal stress fracture criterion. There is a satisfactory consistency between the test and theoretical results. Although the proposed test configuration has limitations in applying the mixed modes of I/III and II/III, it is an efficient test configuration easier and less expensive than other configurations utilizing complex crack geometry or complicated loading fixtures.