bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice
Authors: Han Shuang , Wu Qingqian , Wang Mengying , Yang Miqi , Sun Chen , Liang Jiaqi , Guo Xiaozhen , Zhang Zheyu , Xu Jingya , Qiu Xinyuan , Xie Cen , Chen Siyu , Gao Yue , Meng Zhuo-Xian 
Published: March 2023

Abstract
Exercise intervention at the early stage of type 2 diabetes mellitus (T2DM) can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications. However, the exercise-regulated pathways that prevent the development of T2DM remain largely unclear. In this study, two forms of exercise intervention, treadmill training and voluntary wheel running, were conducted for high-fat diet (HFD)-induced obese mice. We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance. Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training. Metabolomic profiling of the plasma and skeletal muscle in Chow, HFD, and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases. Overlapping analysis identified nine metabolites, including beta-alanine, leucine, valine, and tryptophan, which were reversed by exercise treatment in both the plasma and skeletal muscle. Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis. In addition, integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism, insulin sensitivity, and immune response in the skeletal muscle. This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis.
Moral education, emotions, and social practices
Authors: Mejía Andrés 
Published: March 2023

AbstractPaul Hirst’s idea of moral education is distinctive in the central role it attributes to social practices. For him, ethical principles and virtues should not be seen as abstract entities theoretically derived and then applied in education so that students learn to reason from those principles or live by those virtues. Instead, Hirst’s moral education incorporates an initiation into social practices and comes back to them by means of situated critical reflection from within those practices themselves. Embracing Hirst’s proposed central role of social practices, this paper spells out the key role that emotions play in moral education so understood and their relations with social practices. As emotions materialize our deeply held values, incorporated into lived experience, their cultivation will not simply be a matter of deliberation, but rather of the practical exploration of social practices that can nurture and sustain them.
Emergent initial presentation of congenital malrotation with midgut volvulus in 68-year-old
Authors: Tecos Maria E , Pipinos Margarita , Waibel Brett H 
Published: March 2023

AbstractCongenital malrotation is a pathology nearly exclusive to the infant population. In the rare instance when it is diagnosed in an adult, it is typically associated with a longstanding history of gastrointestinal symptoms. Unfortunately, this unique presentation in an unexpected population has the potential to be confounding, leading to delayed or mismanaged care. Here, we describe an intriguing case of congenital malrotation complicated by midgut volvulus in a 68-year-old woman. Even more curious, the patient did not have a medical history plagued by abdominal complaints. Careful, comprehensive evaluation yielded appropriate surgical management via Ladd’s procedure and right hemicolectomy in this complex patient.
Complex treatment of multiple high-output enterocutaneous fistulas (gastric, jejunum, transversum) after bariatric surgery
Authors: Struchkov Vladimir Yu , Berelavichus Stanislav V , Dvuhzhilov Mihail V , Akhtanin Evgenij A , Kriger Andrej G 
Published: March 2023

AbstractMultiply high-output enterocutaneous fistulas (ECF) is a tragic postoperative complication. This report describes complex treatment of patient with multiple enterocutaneous fistulas after bariatric surgery, including a comprehensive preoperative preparation for 3 months (sepsis control, nutritional support and wound care) and reconstructive surgery (laparotomy, distal gastrectomy, resection of the small bowel with fistulas, Roux-gastrojejunostomy, transversostomy).
Evaluation of Serum Creatinine Levels with Reference Change Value in Patients Receiving Colistin Treatment
Authors: Cinpolat Havva Yasemin , Alkan Sevil , Altinisik Hatice Betul , Cakir Dilek Ulker , Oguzman Hamdi 
Published: March 2023

Abstract

Objective
In this study, we aimed to evaluate the serum creatinine (SCr) levels with the reference change value (RCV) in patients receiving colistin treatment.

Methods
We retrospectively recorded the SCr levels of 47 patients receiving colistin treatment before treatment and on days 3 and 7 after treatment. RCV was calculated with the asymmetrical RCV formula (Z = 1.64, P &lt; .05). Percent (%) increase in the SCr results of the patients was compared with RCV and values exceeding RCV were regarded as statistically significant.

Results
The RCV was calculated as 15.6% for SCr. Compared with pretreatment values, SCr value on day 3 was 32/47 and on day 7 it was 36/47; as these results exceeded RCV, they were considered statistically significant.

Conclusion
Use of RCV in the interpretation of results between serial measurements will provide a more rapid and sensitive method when making decisions.
Beyond the bulge–halo conspiracy? Density profiles of early-type galaxies from extended-source strong lensing
Authors: Etherington Amy , Nightingale James W , Massey Richard , Robertson Andrew , Cao XiaoYue , Amvrosiadis Aristeidis , Cole Shaun , Frenk Carlos S , He Qiuhan , Lagattuta David J , Lange Samuel , Li Ran 
Published: March 2023

ABSTRACTObservations suggest that the dark matter and stars in early-type galaxies ‘conspire’ to produce a surprisingly simple distribution of total mass, ρ(r) ∝ ρ−γ, with γ ≈ 2. We measure the distribution of mass in 48 early-type galaxies that gravitationally lens a resolved background source. By fitting the source light in every pixel of images from the Hubble Space Telescope, we find a mean $\langle \gamma \rangle =2.075_{-0.024}^{+0.023}$ with an intrinsic scatter between galaxies of $\sigma _\gamma =0.172^{+0.022}_{-0.032}$ for the overall sample. This is consistent with and has similar precision to traditional techniques that employ spectroscopic observations to supplement lensing with mass estimates from stellar dynamics. Comparing measurements of γ for individual lenses using both techniques, we find a statistically insignificant correlation of $-0.150^{+0.223}_{-0.217}$ between the two, indicating a lack of statistical power or deviations from a power-law density in certain lenses. At fixed surface mass density, we measure a redshift dependence, $\partial \langle \gamma \rangle /\partial z=0.345^{+0.322}_{-0.296}$, that is consistent with traditional techniques for the same sample of Sloan Lens ACS and GALaxy-Lyα EmitteR sYstems (GALLERY) lenses. Interestingly, the consistency breaks down when we measure the dependence of γ on the surface mass density of a lens galaxy. We argue that this is tentative evidence for an inflection point in the total mass-density profile at a few times the galaxy effective radius – breaking the conspiracy.
Research on the joint timekeeping of pulsars and atomic clocks based on Vondrak–Cepek filtering
Authors: Liu Yang , Xu Bo , Zheng Zehao , Chen Zhengkun , Zhu Xiangwei 
Published: March 2023

ABSTRACTThere is a wide demand for high-precision and high-stability time-scales, which are mainly established by atomic clocks. The short-term stability of atomic clocks is good, while the long-term stability is poor. Meanwhile, millisecond pulsars have good long-term stability. It is expected to produce time-scales with high-stability performance by combining pulsars and atomic clocks to keep time. In this paper, a novel joint timekeeping algorithm based on Vondrak–Cepek filtering is proposed. The filter makes a compromise between the fidelity of the observation data and their first derivatives and the smoothness of the filtering results. Also, it can give full play to the long-term stability of pulsars and the short-term stability of atomic clocks. Experiments and results show that the joint timekeeping algorithm improved σz of 7.58 × 10−13 on 6.5-d time interval with respect to that obtained from the pulsar ensemble time-scale algorithm. Also, the joint timekeeping algorithm improved σz of 6.94 × 10−15 on 9.1-yr time interval with respect to that obtained from the atomic ensemble time-scale algorithm. The algorithm proposed in this paper can be applied to scenes requiring high-stability time-scales.
A Lagrangian construction of rotating star models
Authors: Ogata Misa , Okawa Hirotada , Fujisawa Kotaro , Yasutake Nobutoshi , Yamamoto Yu , Yamada Shoichi 
Published: March 2023

ABSTRACTWe present a new formulation for numerically obtaining axisymmetric equilibrium structures of rotating stars in two spatial dimensions. With a view to apply it to the secular evolution of rotating stars, we base it on the Lagrangian description, i.e. we solve the force-balance equations to find the spatial positions of fluid elements endowed individually with a mass, specific entropy and angular momentum. The system of non-linear equations obtained by finite-differencing the basic equations is solved with the W4 method, which is a new multidimensional root-finding scheme of our own devising. We augment it with a remapping scheme to avoid distortions of the Lagrangian coordinates. In this first one of a series of papers, we will give a detailed description of these methods initially. We then present the results of some test calculations, which include the construction of both rapidly rotating barotropic and baroclinic equilibrium states. We gauge their accuracies quantitatively with some diagnostic quantities as well as via comparisons with the counterparts obtained with an Eulerian code. For a demonstrative purpose, we apply the code to a toy-model cooling calculation of a rotating white dwarf.
Abundance analysis of a nitrogen-rich extreme-helium hot subdwarf from the SALT survey
Authors: Scott L J A , Jeffery C S , Farren D , Tap C , Dorsch M 
Published: March 2023

ABSTRACTWe have performed a detailed spectral analysis of the helium-rich hot subdwarf EC 20187−4939, using data obtained in the SALT survey of helium-rich hot subdwarfs. We have measured its effective temperature, surface gravity, and chemical abundances from the spectrum. Its radius has also been determined by fitting the spectral energy distribution using photometric data, from which a mass of 0.44$^{+0.32}_{-0.19}$ M⊙ has been inferred using the measurement of surface gravity. This star is particularly abundant in helium and nitrogen, whilst being both carbon and oxygen-weak. The surface abundances and mass have been found to be consistent with a helium white dwarf merger product. The abundance effects of alpha captures on nitrogen during the merger process and possible connections between EC 20187−4939, and other carbon-weak related objects are discussed.
Searching for the warm-hot intergalactic medium usingXMM–Newtonhigh-resolution X-ray spectra
Authors: Gatuzz E , García Javier A , Churazov E , Kallman T R 
Published: March 2023

ABSTRACTThe problem of missing baryons in the local universe remains an open question. One proposed alternative is that at low redshifts missing baryons are in the form of the warm-hot intergalactic medium (WHIM). In order to test this idea, we present a detailed analysis of X-ray high-resolution spectra of six extragalactic sources, Mrk 421, 1ES 1028+511, 1ES 1553+113, H2356−309, PKS 0558−504, and PG 1116+215, obtained with the XMM–Newton Reflection Grating Spectrometer to search for signals of WHIM and/or circumgalactic medium X-ray-absorbing gas. We fit the X-ray absorption with the IONeq model, allowing us to take into account the presence of X-ray spectral features due to the multiphase component of the local interstellar medium (ISM). An additional IONeq component is included to model the WHIM absorption, instead of the traditional Gaussian absorption line modelling. We found no statistical improvement in the fits when including such component in any of the sources, concluding that we can safely reject a successful detection of WHIM absorbers towards these lines of sights. Our simulation shows that the presence of the multiphase ISM absorption features prevents the detection of low-redshift WHIM absorption features in the &gt;17 Å spectral region for moderate exposures using high-resolution spectra.
Gamma-ray flares and broad-band spectral study of PKS 0402-362
Authors: Das Avik Kumar , Mondal Sandeep Kumar , Prince Raj 
Published: March 2023

ABSTRACTWe study the long-term behaviour of the bright gamma-ray blazar PKS 0402-362. We collected approximately 13 yr of Fermi-LAT data between August 2008 to January 2021 and identified three bright γ-ray activity epochs. The second was found to be the brightest epoch ever seen in this source. We observed most of the γ-ray flare peaks to be asymmetric in profile suggesting a slow cooling time of particles or the varying Doppler factor as the main cause of these flares. The γ-ray spectrum is fitted with PL and LP spectral models, and in both cases, the spectral index is very steep. The γ-ray spectrum does not extend beyond 10 GeV energy suggesting the emission is produced within the BLR. The absence of time lags between optical-IR and γ-ray suggest one zone emission model. Using the above information, we have modelled the broad-band SED with a simple one-zone emission model using the publicly available code ‘GAMERA’. The particle distribution index is found to be the same as expected in diffusive shock acceleration suggesting it as the main mechanism of particle acceleration to very high energy up to 4–6 GeV. Throughout the various flux phases, we noticed that the optical emission is dominated by the thermal disc, suggesting it to be a good source to examine the disc-jet coupling. We postulate that the observed broad-band flares could be linked with perturbation produced in the disc, which propagates to the jet and interacts with the standing shock. However, a more detailed examination is required.
Distributional effect of import shocks on British local labour markets
Authors: Adem Anwar S 
Published: March 2023

Abstract
This article investigates the causal effect of import shocks on the wage distribution using individual-level data from the UK in the period 1997–2010. The analysis exploits regional variation in initial industrial structure and concentration for identification, and applies a group IV quantile approach to estimate the effect of import shocks on workers at different parts of the wage distribution. The study finds that the effect of import shocks generated by increased import competition is concentrated on the middle of the wage distribution: while the import shocks negatively and significantly affect workers at the bottom-middle of the wage distribution, its effect on the very bottom and upper parts of the wage groups is insignificant. Moreover, the study finds that this labour market adjustment takes place through a reduction in the hourly wage rather than a decline in total hours worked.
Discounting and Intergenerational Ethics
Authors: Zuber Stéphane , Fleurbaey Marc 
Published: March 2023

Abstract
The question of social discounting is central in intertemporal cost–benefit analysis that often shapes economists’ recommendations regarding climate policy. The practice of discounting has been the object of heated debates among economists and philosophers, revolving around the issue of intergenerational ethics. In this chapter, the authors review the different arguments for and against specific values of social discounting. The authors show that there are actually two different ethical issues at stake: (1) the question of impartiality (or equal treatment of all generations) and (2) the question of priority to the worse off (aversion to inequality in resources, capabilities, or welfare). These questions have emerged in the utilitarian approach and can be neatly separated in that case. They also have very different consequences for climate policy. The authors then argue that the question of social discounting is not confined to the utilitarian framework as it more generally describes the social value of income (or capability or welfare) transfers to future generations. Lastly, the authors discuss the many limitations of social discounting as a tool for policy analysis.
Democracy (Not) on Display: A Structural Collocation Analysis of the Mother of All Parliaments’ Reluctance to Broadcast Herself
Authors: van Waarden Betto , Johansson Mathias 
Published: March 2023

AbstractWhy was the British Parliament so late in broadcasting its debates? Scholars have made recommendations on parliamentary communication, analysed its effects, and described the debates and arguments on broadcasting parliament. But who was making these arguments, and what role did parliamentarians’ identities play in these debates? We show the crucial role that partisanship—but also the distinctions between government and opposition, senior and junior, and urban and rural MPs—played in Westminster’s debates on broadcasting itself. We do so by applying our new method of ‘structural collocation analysis’ to all 3965 debate utterances on broadcasting parliament between 1935 and 2014—rather than merely the eleven official debates on broadcasting parliament studied thus far—comparing utterances by subgroups of MPs using metadata that we added to the digitised proceedings. We focus on issue ownership, discursive differences and MPs’ reflections on broadcasting parliament.
Transcranial direct current stimulation to reduce chronic pelvic pain in endometriosis: phase II randomized controlled clinical trial
Authors: Mechsner Sylvia , Grünert Jackie , Wiese Jakob Johann , Vormbäumen Jane , Sehouli Jalid , Siegmund Britta , Neeb Lars , Prüß Magdalena Sarah 
Published: March 2023

Abstract

Background
It is known that various chronic pain conditions lead to maladaptive changes in the central nervous system. Endometriosis is frequently associated with chronic pelvic pain (CPP). Its sufficient treatment remains a clinical challenge. Transcranial direct current stimulation (tDCS) has been shown to be a powerful method to reduce chronic pain. Therefore, this study aimed to investigate pain reduction via anodal tDCS in patients with endometriosis and CPP.

Methods
This clinical phase II, placebo-controlled, randomized, parallel-design study included 36 patients with endometriosis and CPP. All patients had CPP, defined as a score of ≥3/10 on the visual analog scale for ≥3 months in the prior 6 months. Anodal or placebo tDCS (18 patients per arm) was applied over the primary motor cortex for 10 days. The primary outcome measure was the pressure pain threshold (objective pain measure), and secondary outcomes were the numerical rating scale score (subjective pain measure), Von Frey monofilaments, and disease- and pain-related questionnaires. Data were collected at baseline, after the 10-day stimulation, and at a follow-up session, which took place 1 week after the tDCS had ended. Statistical analyses were performed with analyses of variance and t tests.

Results
Significant decreased pain perception in both pain measurements (pressure pain threshold and numerical rating scale score) was found for the active tDCS group compared with the placebo group. This proof-of-concept study shows that tDCS is a helpful supporting pain therapy for patients with endometriosis and CPP. Moreover, further analyses revealed that 1 week after the stimulation had ended, pain reduction as indexed by pressure pain threshold remained significantly decreased, which indicates possible long-term analgesic effects.

Conclusion
The present study provides evidence that tDCS is an effective therapy for pain reduction in endometriosis-associated CPP. The results support the notion that CPP is developed and maintained in the central nervous system, making a multimodal pain therapy necessary.

Trial registration
www.ClinicalTrials.gov ID: NCT05231239.
Local calcium signal transmission in mycelial network exhibits decentralized stress responses
Authors: Itani Ayaka , Masuo Shunsuke , Yamamoto Riho , Serizawa Tomoko , Fukasawa Yu , Takaya Naoki , Toyota Masatsugu , Betsuyaku Shigeyuki , Takeshita Norio 
Published: March 2023

Abstract
Many fungi live as mycelia, which are networks of hyphae. Mycelial networks are suited for the widespread distribution of nutrients and water. The logistical capabilities are critical for the extension of fungal survival areas, nutrient cycling in ecosystems, mycorrhizal symbioses, and virulence. In addition, signal transduction in mycelial networks is predicted to be vital for mycelial function and robustness. A lot of cell biological studies have elucidated protein and membrane trafficking and signal transduction in fungal hyphae; however, there are no reports visualizing signal transduction in mycelia. This paper, by using the fluorescent Ca2+ biosensor, visualized for the first time how calcium signaling is conducted inside the mycelial network in response to localized stimuli in the model fungus Aspergillus nidulans. The wavy propagation of the calcium signal inside the mycelium or the signal blinking in the hyphae varies depending on the type of stress and proximity to the stress. The signals, however, only extended around 1,500 μm, suggesting that the mycelium has a localized response. The mycelium showed growth delay only in the stressed areas. Local stress caused arrest and resumption of mycelial growth through reorganization of the actin cytoskeleton and membrane trafficking. To elucidate the downstream of calcium signaling, calmodulin, and calmodulin-dependent protein kinases, the principal intracellular Ca2+ receptors were immunoprecipitated and their downstream targets were identified by mass spectrometry analyses. Our data provide evidence that the mycelial network, which lacks a brain or nervous system, exhibits decentralized response through locally activated calcium signaling in response to local stress.
Thermodynamics of dilaton black holes charged with a higher-dimensional Coulomb-like field
Authors: Dehghani M 
Published: March 2023

AbstractThe field equations are written explicitly in the framework of higher-dimensional Einstein-dilaton gravity theory, which is coupled to non-linear electrodynamics. It is proved that this theory is confronted with the problem of indeterminacy. By this we mean that the number of unknowns is one more than the unique differential equations. Analytical solutions are obtained by the use of power-law and exponential ansatz functions, separately. It is found that this theory in the presence of a Coulomb-like electric field, inspired by non-linear electrodynamics, admits two novel classes of black hole solutions for each of the ansatz functions. Under the influence of the dilaton field, the asymptotic behavior of the solutions is neither flat nor anti-de Sitter. Through comparison of the results it is shown that, under some simple conditions, both of the ansatz functions lead to the same results. It is illustrated that our exact solutions can produce two-horizon, one-horizon, and horizonless black holes. The validity of the first law of black hole thermodynamics is investigated by use of a Smarr-type mass formula. The thermal stability of the black holes is analyzed by making use of the canonical ensemble and geometrical methods, separately. The results of these two alternative approaches are compared by the use of plots.