bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between vascular access and angulation of vena cava filter at placement and retrieval: a multicenter retrospective cohort study
Authors: Gong Maofeng , Jiang Rui , Zhao Boxiang , Kong Jie , Liu Zhengli , Qian Cheng , He Xu , Gu Jianping 
Published: September 2023

Background: Inferior vena cava (IVC) filters are commonly used intravascular devices designed to prevent fatal pulmonary embolism (PE), maintaining the IVC filter as centered as possible is fundamental for achieving its filtration function. Objective: This study aimed to characterize the tilt angles of IVC filter between the vascular access of internal jugular vein (IJV) and femoral vein (FV), as well as to identify factors associated with increased or decreased tilt angles between placement and retrieval. Design: This is a multicenter retrospective study. Methods: A multicenter retrospective study was conducted from October 2017 to March 2019. The primary outcome was the change in filter tilt between placement and retrieval. The secondary outcome was the identifications of factors associated with increased or decreased tilt angle. Relevant variables were analyzed using t-tests, Chi-square tests, Fisher’s exact tests, while multivariate logistic regression analysis was used to determine risk factors. Results: A total of 184 eligible patients were included in this study. The IJV group had a lower likelihood of tilt angle over 10° at the time of placement compared to the FVs group (0% versus 12.5%, p = 0.040). Among the 171 patients with a mean dwell time of 22.1 days, the IJV group had a higher likelihood of tilt angle over 10° than the FVs group (10.3% versus 2.3%, p = 0.080). The use of FVs access at placement was associated with a higher difference between placement and retrieval filter tilt angles ( p < 0.01). Multivariate logistic regression analysis showed that hypertension [odds ratio (OR) 0.668; 95% confidence interval (CI) 0.328–1.358, p = 0.265], cardiologic artery disease (OR 0.537; 95% CI 0.136–2.130, p = 0.377), cerebral venous disease (OR 0.555; 95% CI 0.186–1.651, p = 0.290), filter types (OR 1.624; 95% CI 0.851–3.096, p = 0.141), and IVC filter thrombosis (OR 1.634; 95% CI 0.804–3.323, p = 0.175) were not associated with increased filter tilt angle. Right side (OR 0.434; 95% CI 0.202–0.930, p = 0.032) or bilateral lower extremity deep vein thrombosis (LEDVT) (OR 0.383; 95% CI 0.148–0.995, p = 0.049) were identified as protective factors. Conclusion: IJV access was associated with a lower filter tilt angle at the time of placement, while FVs access was linked to a higher difference between placement and retrieval tilt angles. Right side or bilateral LEDVT were identified as protective factors against increased IVC filter tilt angle.
Evaluating the feasibility of delivering a pain management programme for adults living with sickle cell disease
Authors: McLoughlin Rebecca , Love Jenna , Smith Jared G , Scott Whitney , Noblet Tim 
Published: September 2023

Background Pain is the prominent feature of sickle cell disease (SCD) and negatively affects quality of life. Delivery of pain management programmes (PMPs) has been suggested in clinical guidelines for pain management in SCD; however, further evidence of the feasibility and effectiveness of PMPs in this population is needed. This study explored the feasibility of delivering a sickle cell pain management programme (SCPMP) for adults within a haemoglobinopathies service. Methods A single arm, repeated-measures observational design was used to determine feasibility of delivering the SCPMP at one study site. Primary feasibility outcomes were recruitment, completion of treatment and outcome measures, satisfaction, credibility and acceptability to participants. Secondary feasibility outcomes were treatment outcomes and processes, frequency of vaso-occlusive crisis (VOC) and healthcare utilisation. Results Four of five feasibility criteria were met. Annual recruitment of eight participants to a SCPMP was not achieved. Twenty-nine people began a SCPMP during the study period. Twenty-five (86.2%) participants attended ≥5/8 sessions and 21(84%) programme completers provided all end of programme questionnaires. Mean scores of >7 on ten-point scales were seen across satisfaction and credibility questions. At least moderate (Hedges g >0.5) effect sizes were seen in pre-post SCPMP measures of pain interference, anxiety, depression, self-efficacy, pain-related worry and acceptance. A small (Hedges g 0.4) effect size was seen in HRQoL. Following SCPMP attendance, mean frequency of self-reported VOC and hospital admissions reduced. Conclusions This study suggests that, given an adequate source of referrals, a SCPMP is feasible to deliver and appears acceptable and credible to participants. Exploration of influences on recruitment, such as barriers to group interventions, would be illuminating, prior to investigating feasibility of an adequately powered randomised-controlled trial.
Sociodemographic Factors, Mental Health, and Emotional Eating Associated With Concern for COVID-19 Contagion in Nurses: A Cross-Sectional Study
Authors: Ricalde-Castillo Yanela , Celis-Mendoza Milagros , Morales-García Mardel , Huancahuire-Vega Salomón , Calizaya-Milla Yaquelin E. , Saintila Jacksaint , Sairitupa-Sanchez Liset Z. , Morales-García Sandra B. , Morales-García Wilter C. 
Published: September 2023

Objective: To determine the association between sociodemographic factors, stress, depression and anxiety, emotional eating, and concern about COVID-19 contagion in first and second-line Peruvian nurses. Methodology: The study was cross-sectional and conducted with 500 Peruvian nurses of both sexes, over 18 years of age. Validated questionnaires were used to measure sociodemographic aspects, concern about COVID-19, generalized anxiety, depression, self-perceived stress, and emotional eating. Multiple linear regression analysis was performed to analyze the factors affecting concern about COVID-19 contagion. Results: The multiple linear regression analysis showed that stress, being between the ages of 18 and 29 years, being male, being from the coastal region or the jungle region, having a bachelor’s degree, severe anxiety, and severe depression were associated with higher concern about COVID-19. On the other hand, having more than 5 to 10 years of experience and more than 10 years of experience, low emotional eating, and non-emotional eating were negatively associated with concern. This model explained 44.05% of the variability among the participating nurses. Conclusion: These findings provide resources for future research on the comprehensive well-being of nursing staff by exploring various sociodemographic aspects and mental conditions associated with greater concern about COVID-19. Meanwhile, years of experience and emotional eating behavior were associated with lower concern about COVID-19. Future studies could incorporate this information to preserve the mental and physical health of nurses in the face of potential occupational threats.
A mixed methods evaluation of a differentiated care model piloted for TB care in south India
Authors: Washington Reynold , Ramanaik Satyanarayana , Kumarasamy Karthikeyan , Sreenivasa Prarthana B , Adepu Rajesham , Reddy Ramesh Chandra , Shah Amar , Swamickan Reuben , Maryala Bala Krishna , Mukherjee Aparna , Pujar Ashwini , Panibatla Vikas , Lakkappa Mohan Harnahalli , Potty Rajaram Subramanian 
Published: September 2023

Background: India’s National TB Elimination Program emphasizes patient-centered care to improve TB treatment outcomes. We describe the lessons learned from the implementation of a differentiated care model for TB care among individuals diagnosed with active TB. Design and methods: Used mixed methods to pilot the Differentiated Care Model. Community health workers (CHWs) conducted a risk and needs assessment among individuals who were recently began TB treatment. Individuals identified with specific factors that are associated with poor treatment adherence were provided education, counseling, and linked to treatment and support services. Examined changes in TB treatment outcomes between the two cohorts of individuals on TB treatment before and after the intervention. We used qualitative research methods to explore the experiences of patients, family members, and front-line TB workers with the implementation of the DCM pilot. Results: The CHWs were adept at the identification of individuals with risks to non-adherence. However, only a few provided differentiated care, as envisioned. There was no significant change in the TB treatment outcomes between the two cohorts of patients examined. CHWs’ ability to provide differentiated care on a scale was limited by the short duration of implementation, their inadequate skills to manage co-morbidities, and the suboptimal support at the field level. Conclusions: It is feasible for a cadre of well-trained front-line workers, mentored and supported by counselors and doctors, to provide differentiated care to those at risk for unfavorable TB treatment outcomes. However, differentiated care must be implemented on a scale for a duration that allows a change from the conventional practice of front-line workers, in order to influence the outcomes of population-level TB treatment.
Perceptions and Opinions on Cannabidiol in the Orthopaedic Sports Medicine Community
Authors: Li Zachary I. , Chalem Isabel , Berzolla Emily , Vasavada Kinjal D. , DeClouette Brittany , Kaplan Kevin M. , Alaia Michael J. 
Published: September 2023

Background: Cannabidiol (CBD) is a known pain modulator that is garnering increased attention in the orthopaedic world. There may be a considerable knowledge gap among orthopaedic sports medicine providers and their perception of its therapeutic value. Purpose: To (1) examine the knowledge and beliefs of sports medicine orthopaedic providers with respect to CBD, (2) deliver an educational component, and (3) elucidate potential barriers to its widespread application. Study Design: Cross-sectional study. Methods: A 3-component, 25-question online survey was distributed to members of the American Orthopaedic Society for Sports Medicine and the Arthroscopy Association of North America between July and October 2022. The first 20 questions assessed baseline knowledge and opinions regarding CBD, followed by an educational component, and then 5 questions assessing whether the respondents’ opinions had changed after learning more about CBD. Responses were compared according to age, practice setting, and state’s cannabinoid legalization status using the chi-square test, and changes in opinions from before to after the educational component were compared using the paired t test. Results: There were 101 survey responses, for a response rate of approximately 1%. Most respondents believed that there is a role for CBD in postoperative pain management (76%), acute pain and inflammation after an injury (62%), and chronic pain (94%). Most respondents admitted that they were not knowledgeable about the mechanism of action (89%) or their state’s laws (66%) concerning CBD. A minority (25%) believed that CBD has psychoactive properties. While most respondents (76%) did not believe that they would be stigmatized if they were to suggest CBD to a patient, only 48% had ever suggested CBD. Notably, 94% of respondents had encountered patients who reported trying CBD to treat pain. After reading the fact sheet, 51% of respondents stated that their opinion on CBD had changed, and 63% felt inclined to investigate the topic further. Conclusion: Most survey respondents believed that CBD has a role in postoperative and chronic pain management. Although there was a relative familiarity with CBD, there was a knowledge gap, suggesting that increased attention, education, and research are necessary.
Hypoxic burden to guide CPAP treatment allocation in patients with obstructive sleep apnoea: apost hocstudy of the ISAACC trial
Authors: Pinilla Lucía , Esmaeili Neda , Labarca Gonzalo , Martinez-Garcia Miguel Ángel , Torres Gerard , Gracia-Lavedan Esther , Mínguez Olga , Martínez Dolores , Abad Jorge , Masdeu Maria José , Mediano Olga , Muñoz Carmen , Cabriada Valentín , Duran-Cantolla Joaquín , Mayos Mercè , Coloma Ramón , Montserrat Josep María , de la Peña Mónica , Hu Wen-Hsin , Messineo Ludovico , Sehhati Mohammadreza , Wellman Andrew , Redline Susan , Sands Scott , Barbé Ferran , Sánchez-de-la-Torre Manuel , Azarbarzin Ali 
Published: September 2023

BackgroundHypoxic burden (HB) has emerged as a strong predictor of cardiovascular risk in obstructive sleep apnoea (OSA). We aimed to assess the potential of HB to predict the cardiovascular benefit of treating OSA with continuous positive airway pressure (CPAP).MethodsThis was apost hocanalysis of the ISAACC trial (ClinicalTrials.gov:NCT01335087) including non-sleepy patients with acute coronary syndrome (ACS) diagnosed with OSA (apnoea–hypopnoea index ≥15 events·h−1) by respiratory polygraphy. Patients were randomised to CPAP or usual care and followed for a minimum of 1 year. HB was calculated as the total area under all automatically identified desaturations divided by total sleep time. Patients were categorised as having high or low baseline HB according to the median value (73.1%min·h−1). Multivariable Cox regression models were used to assess whether the effect of CPAP on the incidence of cardiovascular outcomes was dependent on the baseline HB level.ResultsThe population (362 patients assigned to CPAP and 365 patients assigned to usual care) was middle-aged (mean age 59.7 years), overweight/obese and mostly male (84.5%). A significant interaction was found between the treatment arm and the HB categories. In the high HB group, CPAP treatment was associated with a significant reduction in the incidence of cardiovascular events (HR 0.57, 95% CI 0.34–0.96). In the low HB group, CPAP-treated patients exhibited a trend toward a higher risk of cardiovascular outcomes than those receiving usual care (HR 1.33, 95% CI 0.79–2.25). The differential effect of the treatment depending on the baseline HB level followed a dose–response relationship.ConclusionIn non-sleepy ACS patients with OSA, high HB levels were associated with a long-term protective effect of CPAP on cardiovascular prognosis.
Octane in exhaled breath to diagnose acute respiratory distress syndrome in invasively ventilated intensive care unit patients
Authors: Hagens Laura A. , Heijnen Nanon F.L. , Smit Marry R. , Verschueren Alwin R.M. , Nijsen Tamara M.E. , Geven Inge , Presură Cristian N. , Rietman Ronald , Fenn Dominic W. , Brinkman Paul , Schultz Marcus J. , Bergmans Dennis C.J.J. , Schnabel Ronny M. , Bos Lieuwe D.J. 
Published: September 2023

BackgroundThe concentration of exhaled octane has been postulated as a reliable biomarker for acute respiratory distress syndrome (ARDS) using metabolomics analysis with gas chromatography and mass spectrometry (GC-MS). A point-of-care (POC) breath test was developed in recent years to accurately measure octane at the bedside. The aim of the present study was to validate the diagnostic accuracy of exhaled octane for ARDS using a POC breath test in invasively ventilated intensive care unit (ICU) patients.MethodsThis was an observational cohort study of consecutive patients receiving invasive ventilation for at least 24 h, recruited in two university ICUs. GC-MS and POC breath tests were used to quantify the exhaled octane concentration. ARDS was assessed by three experts following the Berlin definition and used as the reference standard. The area under the receiver operating characteristic curve (AUC) was used to assess diagnostic accuracy.Results519 patients were included and 190 (37%) fulfilled the criteria for ARDS. The median (interquartile range) concentration of octane using the POC breath test was not significantly different between patients with ARDS (0.14 (0.05–0.37) ppb) and without ARDS (0.11 (0.06–0.26) ppb; p=0.64). The AUC for ARDS based on the octane concentration in exhaled breath using the POC breath test was 0.52 (95% CI 0.46–0.57). Analysis of exhaled octane with GC-MS showed similar results.ConclusionsOctane in exhaled breath has insufficient diagnostic accuracy for ARDS. This disqualifies the use of octane as a biomarker in the diagnosis of ARDS and challenges most of the research performed up to now in the field of exhaled breath metabolomics.
KidneyGPS: a user-friendly web application to help prioritize kidney function genes and variants based on evidence from genome-wide association studies
Authors: Stanzick Kira J. , Stark Klaus J. , Gorski Mathias , Schödel Johannes , Krüger René , Kronenberg Florian , Warth Richard , Heid Iris M. , Winkler Thomas W. 
Published: September 2023

Abstract
Background
Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these findings with post-GWAS information (e.g., statistical fine-mapping to identify independent association signals and to narrow down signals to causal variants; or different sources of annotation data), new hypotheses regarding physiology and disease aetiology can be obtained. These hypotheses need to be tested in laboratory experiments, for example, to identify new therapeutic targets. For this purpose, the evidence obtained from GWAS and post-GWAS analyses must be processed and presented in a way that they are easily accessible to kidney researchers without specific GWAS expertise.

Main
Here we present KidneyGPS, a user-friendly web-application that combines genetic variant association for estimated glomerular filtration rate (eGFR) from the Chronic Kidney Disease Genetics consortium with annotation of (i) genetic variants with functional or regulatory effects (“SNP-to-gene” mapping), (ii) genes with kidney phenotypes in mice or human (“gene-to-phenotype”), and (iii) drugability of genes (to support re-purposing). KidneyGPS adopts a comprehensive approach summarizing evidence for all 5906 genes in the 424 GWAS loci for eGFR identified previously and the 35,885 variants in the 99% credible sets of 594 independent signals. KidneyGPS enables user-friendly access to the abundance of information by search functions for genes, variants, and regions. KidneyGPS also provides a function (“GPS tab”) to generate lists of genes with specific characteristics thus enabling customizable Gene Prioritisation (GPS). These specific characteristics can be as broad as any gene in the 424 loci with a known kidney phenotype in mice or human; or they can be highly focussed on genes mapping to genetic variants or signals with particularly with high statistical support. KidneyGPS is implemented with RShiny in a modularized fashion to facilitate update of input data (https://kidneygps.ur.de/gps/).

Conclusion
With the focus on kidney function related evidence, KidneyGPS fills a gap between large general platforms for accessing GWAS and post-GWAS results and the specific needs of the kidney research community. This makes KidneyGPS an important platform for kidney researchers to help translate in silico research results into in vitro or in vivo research.
Genome-wide identification and expression analysis of PtJAZ gene family in poplar (Populus trichocarpa)
Authors: Yang Gaixia , Wang Shijie , Long Lianxiang , Yu Xiaoyue , Cai Hongyu , Chen Pengyun , Gu Lijiao , Yang Minsheng 
Published: September 2023

Abstract
Background
The jasmonate ZIM domain (JAZ) protein is a key repressor of the jasmonate signal transduction pathway, which plays an important role in plant growth and development and defense responses. In this study, based on the published whole-genome data, we identified members of the JAZ gene family in Populus trichocarpa. Through a series of bioinformatic approaches, their expression patterns under various stress conditions have been analyzed to explore and excavate the endogenous resistance genes of poplar and provide a theoretical basis for breeding new varieties of poplar resistance.

Results
A total of 13 PtJAZ genes have been identified in P. trichocarpa and designated as PtJAZ1–PtJAZ13. Those 13 PtJAZ genes were unevenly distributed on nine chromosomes, and they could be divided into four subfamilies. The gene structures and motif composition of the members derived from the same subfamily were similar. Collinearity analysis demonstrated that, compared with Arabidopsis thaliana and Oryza sativa, the most collinear pairs (13) were found in P. trichocarpa and Eucalyptus robusta. Cis-acting element analysis suggested that the promoter regions of PtJAZs contained a large number of hormones and stress response elements, of which abscisic acid (ABA) and methyl jasmonate (MeJA) hormone response elements were the most abundant. The PtJAZ genes not only had diverse expression patterns in different tissues, but they also responded to various abiotic and biotic stress conditions. The co-expression network and GO and KEGG analyses showed that JAZ genes were closely related to insect resistance.

Conclusions
In this study, applying bioinformatic methods, 13 PtJAZ gene family members from P. trichocarpa were identified and comprehensively analyzed. By further studying the function of the poplar JAZ gene family, the aim is to select genes with better insect resistance and stress resistance so as to lay a solid foundation for the subsequent breeding of new poplar varieties.
Silicon supply promotes differences in growth and C:N:P stoichiometry between bamboo and tree saplings
Authors: Liu Xiaoyu , Tang Xinghao , Compson Zacchaeus G. , Huang Dongmei , Zou Guiwu , Luan Fenggang , Song Qingni , Fang Xiong , Yang Qingpei , Liu Jun 
Published: September 2023

Abstract
Background
Si can be important for the growth, functioning, and stoichiometric regulation of nutrients for high-Si-accumulating bamboo. However, other trees do not actively take up dissolved silicic acid [Si(OH)4] from the soil, likely because they have fewer or no specific Si transporters in their roots. It is unclear what causes differential growth and C:N:P stoichiometry between bamboo and other trees across levels of Si supply.

Results
Si supply increased the relative growth rate of height and basal diameter of bamboo saplings, likely by increasing its net photosynthetic rate and ratios of N:P. Moreover, a high concentration of Si supply decreased the ratio of C:Si in bamboo leaves due to a partial substitution of C with Si in organic compounds. We also found that there was a positive correlation between leaf Si concentration and its transpiration rate in tree saplings.

Conclusions
We demonstrated that Si supply can decrease the ratio of C:Si in bamboo leaves and increase the ratio of N:P without altering nutrient status or the N:P ratio of tree saplings. Our findings provide experimental data to assess the different responses between bamboo and other trees in terms of growth, photosynthesis, and C:N:P stoichiometry. These results have implications for assessing the growth and competition between high-Si-accumulating bamboo and other plants when Si availability is altered in ecosystems during bamboo expansion.