bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living cellular constructs for keratinized tissue augmentation: A 13‐year follow‐up from a split‐mouth randomized, controlled, clinical trial
Authors: Tavelli Lorenzo , Barootchi Shayan , Rodriguez Maria Vera , Travan Suncica , Oh Tae‐Ju , Neiva Rodrigo , Giannobile William V. 
Published: May 2023

AbstractBackgroundA 13‐year follow‐up was conducted of a short‐term investigation of the use of living cellular construct (LCC) versus free gingival graft (FGG) for keratinized tissue width (KTW) augmentation in natural dentition, to evaluate the long‐term outcomes and assess the changes occurring since the end of the original 6‐month study.MethodsTwenty‐four subjects out of the original 29 enrolled participants were available at the 13‐year follow‐up. The primary endpoint was the number of sites demonstrating stable clinical outcomes from 6 months to 13 years (defined as KTW gain, stability, or ≤0.5 mm of KTW loss, together with reduction, stability, or increase of probing depth, and recession depth [REC] ≤0.5 mm). Secondary outcomes included the assessment of KTW, attached gingiva width (AGW), REC, clinical attachment level, esthetics, and patient‐reported outcomes at the 13‐year visit, assessing the changes from baseline to 6 months.ResultsNine sites per group (42.9%) were found to have maintained stable (≤0.5 mm or improved) clinical outcomes from 6 months to 13 years. No significant differences were observed for the clinical parameters between LCC and FGG from 6 months to 13 years. However, the longitudinal mixed model analysis showed that FGG delivered significantly better clinical outcomes over 13 years (p < 0.01). LCC‐treated sites exhibited superior esthetic outcomes compared to FGG‐treated sites at 6 months and 13 years (p < 0.01). Patient‐evaluated esthetics were significantly higher for LCC over FGG (p < 0.01). Patient overall treatment preference was also in favor of LCC (p < 0.01).ConclusionsA similar stability of the treatment outcomes from 6 months to 13 years was found for LCC‐ and FGG‐treated sites, with both approaches shown to be effective in augmenting KTW and AGW. However, superior clinical outcomes were found for FGG over 13 years, while LCC was associated with better esthetics and patient‐reported outcomes than FGG.
Inhibition of angiotensin II type 1 receptor reduces oxidative stress damage to the intestinal barrier in severe acute pancreatitis
Authors: Gao Zhao‐Yu , Jiang Ying‐Jian , Wang Jiang , Li Chang , Zhang Dian‐Liang 
Published: May 2023

AbstractIntestinal barrier injury is a common complication of severe acute pancreatitis (SAP), which is often accompanied by intestinal mucosal barrier injury and results in serious consequences. However, the exact mechanism remains unclear. We aimed to investigate whether angiotensin II type 1 receptor (AT1)‐mediated oxidative stress is involved in SAP intestinal barrier injury and assessed the effects of inhibiting this pathway. The SAP model was established by retrograde bile duct injection of sodium taurocholate (5%). The rats were divided into three groups: the control group (SO), the SAP group (SAP), and the azilsartan intervention group (SAP + AZL). Serum amylase, lipase, and other indexes were measured to evaluate SAP severity in each group. Histopathological changes in the pancreas and intestine were evaluated by HE staining. The oxidative stress of intestinal epithelial cells was detected by superoxide dismutase and glutathione. We also detected the expression and distribution of intestinal barrier‐related proteins. The results showed that the serum indexes, the severity of tissue damage, and the level of oxidative stress in the SAP + AZL group were significantly lower than in the SAP group. Our study provided hitherto undocumented evidence of AT1 expression in the intestinal mucosa, confirming that AT1‐mediated oxidative stress is involved in SAP intestinal mucosal injury, and inhibiting this pathway could effectively reduce intestinal mucosal oxidative stress injury, providing a new and effective target for the treatment of SAP intestinal barrier injury.
Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR‐1343‐3p/Bcl‐3 axis through TGFβ/Smad3/EMT signaling
Authors: Ge Peng , Chen Xin , Liu Juan , Jing Ruijun , Zhang Xingxing , Li Hanjie 
Published: May 2023

AbstractNonsmall cell lung cancer (NSCLC) is the leading cause of cancer‐related mortality worldwide. Circular RNAs (circRNAs) have been the focus of numerous studies, and some circRNAs have been linked to the development of multiple malignant tumors, including NSCLC. Nevertheless, the functional role and mechanisms of circRNAs in NSCLC remain largely unknown. The primary objective of this study was to screen the associated circRNA in NSCLC and investigate its mechanism. CircRNA microarray was used to identify circRNAs that were abnormally expressed in NSCLC tissue samples. Expression of hsa_circRNA_0088036 was validated in NSCLC tissues and cell lines after the correlation between hsa_circRNA_0088036 and prognosis was determined. We then used a series of function gain‐and‐loss assays to determine the role of hsa_circ_0088036 in NSCLC progression. RNA‐binding protein immunoprecipitation (RIP), RNA pull‐down, and RNA interference assays were used to assess the interaction between hsa_circ_0088036 and miR‐1343‐3p/Bcl‐3 axis. Moreover, mechanistic assays were applied to investigate the involved signaling pathway regulated by the hsa_circ_0088036/miR‐1343‐3p/Bcl‐3 axis. Microarray analysis and reverse transcription polymerase chain reaction confirmed the presence of a circRNA termed hsa_circ 0088036 that was upregulated in NSCLC tissue samples and cell lines and indicated a positive association with patient prognosis. Functionally, hsa_circ_0088036 silencing inhibited proliferative, invasive, and migrative potential of NSCLC cells as well as epithelial‐mesenchymal transition (EMT)‐related proteins by sponging miR‐1343‐3p to inhibit Bcl‐3. Furthermore, mechanistic experiments demonstrated that hsa_circ_0088036 promoted NSCLC progression by activating the TGFβ/Smad3/EMT signaling pathway via miR‐1343‐3p/Bcl‐3 axis. In conclusion, hsa_circ_0088036 functions as an oncogene by targeting the miR‐1343‐3p/Bcl‐3 axis via TGFβ/Smad3/EMT signaling pathway.
Saturated‐unsaturated seepage simulation and hydrological dam models for quantifying the heterogeneity to hydrological state variables: Impacts of auxiliary structures and leakage anomalies
Authors: Lei Yi , Dai Qianwei , Zhang Bin , Zhou Wei , Yang Junsheng 
Published: May 2023

AbstractSeepage analysis is the central issue in solving the unconfined seepage problems from complex earth‐rock dams. The precision and efficiency of seepage simulation are the major technical barriers to exploring the heterogeneities of hydrological state variables in dams. This paper addresses the heterogeneity of the saturated‐unsaturated zones of dams and develops the smoothed finite element method (S‐FEM) capable of solving the seepage problem in domains with arbitrary geometry and continuously varied permeability. The gradient smoothing technique, in which the area integrals are transformed into the line integrals around edges of smoothing cells, is used to obtain the element matrices, which is used to simplify the solution of seepage problem. To be specific, we employ Van Genuchten method to modify the hydraulic conductivity of unsaturated zones medium and Signorini condition to convert the outflow boundary into the water head boundaries. The precision of the proposed method together with the importance of considering the unsaturated zones are first deliberated by the verification tests. Then, to quantify the impacts on the hydrological state variables, we focus on the heterogeneity of the entire zones through exploratory tests. The results show that the presence of leakage anomalies and auxiliary dam structures has a significant effect on the redistribution of hydrological state variables, which convinces that the findings may lay the foundation for the development of multi‐parameter seepage inversion and the derivation of coupled hydro‐geophysical inversion using the most appropriate starting model.
The state‐of‐the‐art and future research directions in bequest fundraising by nonprofit organizations: A systematic literature review
Authors: Bizzarri Alex , Cardinali Silvio 
Published: May 2023

AbstractThe topic of fundraising is garnering increased attention from nonprofit practitioners due to the worldwide growth of the nonprofit sector and the subsequent competition for private funds. Despite this surge, academic literature on fundraising and bequest fundraising, in particular, has remained mainly limited to narrow aspects of the discipline. Based on a systematic review of literature published over the past 25 years, we synthesize various research perspectives into a comprehensive framework of studies linking the different issues highlighted by the authors. The purpose of this article is to consolidate the state of academic research on bequest fundraising by not‐for‐profit organizations. The literature review underscores how research efforts have not paid much attention to bequest fundraising from the NPO's perspective, although as it has become an increasingly important source of income for charitable organizations. The majority of studies focus on the Donor's perspective, striving to understand what drives the desire to leave a charitable bequest. The findings of the SLR show a gap in the knowledge of NPOs' internal mechanisms concerning the particular topic of charitable bequests; from these insights, the future research directions are proposed.
A combined adaptive entropy‐TOPSIS and model predictive control strategy for mixed loading and delay operations in the reheating furnace
Authors: Yang Zhi , Luo Xiaochuan , Qiao Jinwei 
Published: May 2023

SummaryIn this paper, a combined adaptive entropy‐TOPSIS and model predictive control strategy is proposed to deal with the mixed loading and delay operations in the reheating furnace. Firstly, the mathematical models consistent with the behaviour of the real reheating furnace are built to describe the complicated heat exchange process. Secondly, a dynamical optimization problem for the mixed loading operation and delay operation in the walking beam reheating furnace is obtained. To adjust the weighting factors of the optimization problem in real time, the adaptive entropy‐TOPSIS method is proposed. Then, the rolling horizon approach is applied to solve the proposed optimization problem. Finally, numerical experiments and simulation analysis are undertaken to verify the reliability and accuracy of the proposed strategy. The simulation results demonstrate that the proposed strategy can deal with three typical cases of delays effectively and the control accuracy is successfully improved from 74.79% to 99.17%.
The impact of concurrent X chromosome anomalies on diagnosis and bleeding phenotype in children with hemophilia: A single‐institution case series
Authors: Soffer Elizabeth , Coleman Karlene , Batsuli Glaivy 
Published: May 2023

AbstractHemophilia is an inherited X‐linked bleeding disorder characterized by deficiencies of factors VIII or IX. Concomitant X chromosome disorders can impact bleeding phenotype, complicating timely diagnosis and disease management. Herein, we describe three cases of female and male pediatric patients with hemophilia A or B diagnosed between 6 days and 4 years old in the setting of skewed X chromosome inactivation, Turner syndrome, or Klinefelter syndrome. All of these cases had significant bleeding symptoms, and two patients required initiation of factor replacement therapy. One female patient developed a factor VIII inhibitor similar to that described in males with hemophilia A.
Improvement of “point‐plane”‐like hetero‐structured fillers on thermal conductivity of poly(vinyl alcohol) composites
Authors: Zhang Haoran , Xu Shuyan 
Published: May 2023

AbstractWith the rapid growth of highly integrated electrical devices, the urgent demand for polymer composites with high thermal conductivity (TC) is increasing for effective thermal management. In this work, boron nitride nanosheets (BNNSs) were chemically grafted with aluminum oxide (Al2O3) to develop hetero‐structured filler (BNNSs@Al2O3). The BNNSs@Al2O3 fillers were uniformly dispersed in the poly(vinyl alcohol) (PVA) by solvent mixing, verified by SEM, and the oriented BNNSs@Al2O3/PVA composites were produced by the doctor blade method. The results exhibited that the synergistic effect of BNNSs and Al2O3 was achieved, and the thermal conductivities of BNNSs@Al2O3/PVA composites were improved. When keeping the filler content at 30 wt%, the in‐plane and out‐of‐plane TC of BNNSs@Al2O3/PVA composite reached 5.641 and 0.651 W/(m·K), respectively. The BNNSs@Al2O3 filler may improve the performance of composite heat dissipation by reducing the interfacial resistance between fillers and making it easier to establish directed heat‐transfer pathways. This composite demonstrates promising application in the field of electronic packaging.
The effect of activity and face masks on exhaled particles in children
Authors: Moschovis Peter P. , Lombay Jesiel , Rooney Jennifer , Schenkel Sara R. , Singh Dilpreet , Rezaei Shawheen J. , Salo Nora , Gong Amanda , Yonker Lael M. , Shah Jhill , Hayden Douglas , Hibberd Patricia L. , Demokritou Philip , Kinane T. Bernard 
Published: May 2023

ABSTRACTImportanceDespite the high burden of respiratory infections among children, the production of exhaled particles during common activities and the efficacy of face masks in children have not been sufficiently studied.ObjectiveTo determine the effect of type of activity and mask usage on exhaled particle production in children.MethodsHealthy children were asked to perform activities that ranged in intensity (breathing quietly, speaking, singing, coughing, and sneezing) while wearing no mask, a cloth mask, or a surgical mask. The concentration and size of exhaled particles were assessed during each activity.ResultsTwenty‐three children were enrolled in the study. Average exhaled particle concentration increased by intensity of activity, with the lowest particle concentration during tidal breathing (1.285 particles/cm3 [95% CI 0.943, 1.627]) and highest particle concentration during sneezing (5.183 particles/cm3 [95% CI 1.911, 8.455]). High‐intensity activities were associated with an increase primarily in the respirable size (≤ 5 µm) particle fraction. Surgical and cloth masks were associated with lower average particle concentration compared to no mask (P = 0.026 for sneezing). Surgical masks outperformed cloth masks across all activities, especially within the respirable size fraction. In a multivariable linear regression model, we observed significant effect modification of activity by age and by mask type.InterpretationSimilar to adults, children produce exhaled particles that vary in size and concentration across a range of activities. Production of respirable size fraction particles (≤ 5 µm), the dominant mode of transmission of many respiratory viruses, increases significantly with coughing and sneezing and is most effectively reduced by wearing surgical face masks.
Can nanotechnology improve the application of bioherbicides?
Authors: Pérez‐de‐Luque Alejandro 
Published: May 2023

AbstractBioherbicides are composed of microorganisms or natural compounds and are used for weed control; however, they have specific weaknesses and constraints that hinder their development and success under field conditions. Nanotechnology can help to overcome these limitations by providing a good starting point for the design of specific formulations and carriers that minimize the deficiencies of natural compounds and microorganisms, such as low solubility, short shelf life or a loss of viability. In addition, nanoformulations can help to improve the efficacy of bioherbicides by increasing their effectiveness and bioavailability, reducing the amount required for a treatment, and enhancing their ability to target specific weeds while preserving the crop. However, it is important to choose the right materials and nanodevices depending on specific needs and considering several factors inherent to nanomaterials such as production cost, safety or possible toxic effects. © 2023 Society of Chemical Industry.
Analysis of cascading probabilistic common cause failures
Authors: Wang Chaonan , Lie Yingxi , Xing Liudong , Guan Quanlong , Yang Chunhui , Yu Min 
Published: May 2023

AbstractCommon cause failures may contribute significantly to the reliability of a system and has attracted considerable research attentions. However, the existing models often assumed deterministic failures of components affected by the common cause (CC) and no cascading effects. This paper contributes by modeling cascading probabilistic common cause failures (CPCCFs), where a CC may cause multiple system components to fail with different probabilities and some components may fail in a domino chain manner. An explicit, analytical method is proposed for the reliability analysis of systems subject to CPCCFs, which may be triggered by external or internal CCs. The complex cascading effects are modeled using a directed acyclic graph structure. The proposed method has no limitation on the component time‐to‐failure distributions. Applications and advantages of the proposed method are illustrated through a detailed case study of a safety instrumented system for oil and gas transportation. Correctness of the proposed method is verified by Monte Carlo simulations. The time and space complexity of the method is also studied.
Exercise intervention during chemotherapy for pancreatic cancer: Changes in body composition and function
Authors: Schmitz Kathryn H. , Boutin Robert D. , Yoon James P. , Potiaumpai Melanie , Lenchik Leon , White Carissa M. , Chang Victor 
Published: May 2023

AbstractBackgroundPatients with pancreatic cancer often lose weight during chemotherapy with associated changes in body composition. The goal of the present analysis was to describe changes in body composition in pancreatic cancer patients on an exercise regimen. The long‐term goal is to determine whether an exercise intervention may attenuate changes in body composition and function.MethodsTwenty‐two pancreatic cancer patients of all stages who were to receive chemotherapy were recruited into a pre‐post exercise intervention study. A standard exercise prescription was individualized to include aerobic, resistance, stretch, and balance exercises. Pre‐ and post‐intervention computed tomography‐derived measures of body composition [skeletal muscle index (SMI), skeletal muscle density, visceral fat area, and subcutaneous fat area] and physical function measures (grip strength, timed up and go, 30‐s chair stand, and tandem balance stand) were evaluated using pairedt‐tests, χ2tests, and Pearson correlation coefficients.ResultsThe subjects were, on average, 62 years of age, 55% were female, 95% non‐Hispanic White, and 45% were Stage IV. Body composition changes included a median 4.6% decrease in SMI (P = 0.04), 7.91% increase in skeletal muscle density (P = 0.05), 25.07% decrease in visceral fat area (P = 0.0001), and 22.08% decrease in subcutaneous fat area (P = 0.001). Adherence to aerobic and strength exercise was 65% and 57%, respectively. Some physical function measures improved, though not significantly: chair stands increased from a mean of 11.5 to 13.0 (P = 0.59) and timed up and go improved from a mean of 11.7 to 10.3 (P = 0.26). Change in right hand grip strength was marginally positively associated with changes in SMI (r = 0.53,P = 0.06). Improvements in skeletal muscle density were seen in 63% of patients, including Stage IV patients but did not correlate with change in function.ConclusionsExercise is feasible during neoadjuvant chemotherapy for pancreatic cancer patients of all stages and may assist with maintaining physical function and improving body composition. Further research is needed.
Natural quasirandomness properties
Authors: Coregliano Leonardo N. , Razborov Alexander A. 
Published: May 2023

AbstractThe theory of quasirandomness has greatly expanded from its inaugural graph theoretical setting to several different combinatorial objects such as hypergraphs, tournaments, permutations and so forth. However, these quasirandomness variants have been done in an ad‐hoc case‐by‐case manner. In this article, we propose three new hierarchies of quasirandomness properties that can be naturally defined for arbitrary combinatorial objects. Our properties are also “natural” in more formal sense: they are preserved by local combinatorial constructions. Similarly to hypergraph quasirandomness properties, we show that our quasirandomness properties have several different but equivalent characterizations. We also prove several implications and separations comparing them to each other and to what has been known for hypergraphs. The main notion explored is that of unique coupleability: two limit objects are uniquely coupleable if there is only one way to align (i.e., couple) them.
Robust rank‐based meta‐analyses for two‐sample designs with application to platelet counts of malaria infection data
Authors: Lang Yanda , McKean Joseph W. , Ozturk Omer 
Published: May 2023

AbstractIn this paper, we propose robust meta‐analysis procedures for individual studies that report a broad range of robust summary statistics for a two‐sample problem. Summary statistics of individual studies could be presented in different forms including full data, medians of the two samples, the Hodges‐Lehman and Wilcoxon estimates of the location shift parameters. Data synthesis is made under both fixed‐effect and random‐effect meta‐analysis models. We systematically compare these robust meta‐analysis procedures via simulation studies to meta‐analysis procedure based on sample means and variances from individual studies under a wide range of error distributions. We show that the coverage probabilities of the robust meta‐analysis confidence intervals are quite close to the nominal confidence level. We also show that mean square error (MSE) of the robust meta‐analysis estimator is considerably smaller than that of the non‐robust meta‐analysis estimator under the contaminated normal, heavy tailed and skewed error distributions. The robust meta‐analysis procedures are then applied to platelet count reduction for malaria infected patients in Ghana.
Introduction
Authors: Hill Helena , Brink Pinto Andrés 
Published: May 2023

AbstractThis edited volume discusses the emergence and development, and in some cases also the disappearance, of social movements and activism in the Swedish 1980s. The introductory chapter gives the background and aim of the volume and discusses why the Swedish case is interesting from a European perspective. The 1980s have often been described as a decade when the radical social movements of the 1960s and 1970s lost their influence in society and instead, right-wing politics and neoliberalism gained increasingly more impact in many parts of the world. However, this image needs to be problematized, since the decade encompassed a number of social movements that opposed the political development and protested against neoliberal and conservative politics. This introductory chapter discusses the historical background to the development in Sweden and argues that the ideas of a Swedish exceptionalism and development through consensus needs to be problematized. Contentious social movements have had an important role in democratization processes of Scandinavian societies. The chapter describes the right-wing wave that took place during the 1980s but also the many protests and resistance that occurred against it. It also discusses the importance of complex and multidimensional historiographies. This is followed by a section on political development during the 1980s, both internationally and in Sweden, and what new social movements emerged during the decade. After that, we describe key concepts and theories in research on social movements that some or all contributions engage with. Finally, the common thread in the anthology’s contributions and their main content is described.