bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cox proportional hazards deep neural network identifies peripheral blood complete remission to be at least equivalent to morphologic complete remission in predicting outcomes of patients treated with azacitidine—A prospective cohort study by the AGMT
Authors: Pleyer Lisa , Vaisband Marc , Drost Manuel , Pfeilstöcker Michael , Stauder Reinhard , Heibl Sonja , Sill Heinz , Girschikofsky Michael , Stampfl‐Mattersberger Margarete , Pichler Angelika , Hartmann Bernd , Petzer Andreas , Schreder Martin , Schmitt Clemens A. , Vallet Sonia , Melchardt Thomas , Zebisch Armin , Pichler Petra , Zaborsky Nadja , Machherndl‐Spandl Sigrid , Wolf Dominik , Keil Felix , Hasenauer Jan , Larcher‐Senn Julian , Greil Richard 
Published: August 2023

AbstractThe current gold standard of response assessment in patients with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML), and acute myeloid leukemia (AML) is morphologic complete remission (CR) and CR with incomplete count recovery (CRi), both of which require an invasive BM evaluation. Outside of clinical trials, BM evaluations are only performed in ~50% of patients during follow‐up, pinpointing a clinical need for response endpoints that do not necessitate BM assessments. We define and validate a new response type termed “peripheral blood complete remission” (PB‐CR) that can be determined from the differential blood count and clinical parameters without necessitating a BM assessment. We compared the predictive value of PB‐CR with morphologic CR/CRi in 1441 non‐selected, consecutive patients diagnosed with MDS (n = 522; 36.2%), CMML (n = 132; 9.2%), or AML (n = 787; 54.6%), included within the Austrian Myeloid Registry (aMYELOIDr; NCT04438889). Time‐to‐event analyses were adjusted for 17 covariates remaining in the final Cox proportional hazards (CPH) model. DeepSurv, a CPH neural network model, and permutation‐based feature importance were used to validate results. 1441 patients were included. Adjusted median overall survival for patients achieving PB‐CR was 22.8 months (95%CI 18.9–26.2) versus 10.4 months (95%CI 9.7–11.2) for those who did not; HR = 0.366 (95%CI 0.303–0.441; p < .0001). Among patients achieving CR, those additionally achieving PB‐CR had a median adjusted OS of 32.6 months (95%CI 26.2–49.2) versus 21.7 months (95%CI 16.9–27.7; HR = 0.400 [95%CI 0.190–0.844; p = .0161]) for those who did not. Our deep neural network analysis‐based findings from a large, prospective cohort study indicate that BM evaluations solely for the purpose of identifying CR/CRi can be omitted.
Increased risk of sleep problems according to employment precariousness among paid employees in Korea
Authors: Gong Seong Chan , Park Sungjin 
Published: August 2023

AbstractBackgroundThis study aimed to investigate the relationship between precarious employment (PE) and sleep problems among wage workers in Korea.MethodsData from 29,437 wage workers were obtained from the 6th Korean Working Conditions Survey. PE was defined based on four dimensions: employment temporariness, irregularity, lack of protection, and economic vulnerability. A PE index indicating employment precariousness was derived. The outcome variables were three sleep problems experienced over the past year: difficulty initiating asleep; difficulty maintaining sleep' and fatigue upon waking. Multiple logistic regression was performed after adjusting for age, educational level, occupation, job tenure, company size, and working hours, to estimate the association between PE and sleep problems.ResultsFor both sexes, the risk of all sleep problems significantly increased as the precariousness of employment increased, showing a dose–response relationship.ConclusionAn increased risk of sleep problems is evident as employment becomes more precarious. These findings could help improve the health of workers with PE by addressing sleep problems.
Evaluation of narrow‐band imaging in the diagnosis of sinonasal inverted papilloma
Authors: Benchetrit Liliya , Thomson Evan , Paz‐Lansberg Marianella , Platt Michael P. , Brook Christopher D. 
Published: August 2023

Key Points
Narrow‐band imaging (NBI) can be used to differentiate benign sinonasal lesions
NBI can be used in the preoperative identification of sinonasal inverted papilloma
Future studies can focus on NBI for recurrent inverted papilloma and surgical margin guidance
Reconstructing Hydrogen Bond Network Enables High Voltage Aqueous Zinc‐Ion Supercapacitors
Authors: Hu Zhiyu , Song Zirui , Huang Zhaodong , Tao Shusheng , Song Bai , Cao Ziwei , Hu Xinyu , Wu Jiae , Li Fengrong , Deng Wentao , Hou Hongshuai , Ji Xiaobo , Zou Guoqiang 
Published: August 2023

AbstractHigh‐voltage aqueous rechargeable energy storage devices with safety and high specific energy are hopeful candidates for the future energy storage system. However, the electrochemical stability window of aqueous electrolytes is a great challenge. Herein, inspired by density functional theory (DFT), polyethylene glycol (PEG) can interact strongly with water molecules, effectively reconstructing the hydrogen bond network. In addition, N, N‐dimethylformamide (DMF) can coordinate with Zn2+, assisting in the rapid desolvation of Zn2+ and stable plating/stripping process. Remarkably, by introducing PEG400 and DMF as co‐solvents into the electrolyte, a wide electrochemical window of 4.27 V can be achieved. The shift in spectra indicate the transformation in the number and strength of hydrogen bonds, verifying the reconstruction of hydrogen bond network, which can largely inhibit the activity of water molecule, according well with the molecular dynamics simulations (MD) and online electrochemical mass spectroscopy (OEMS). Based on this electrolyte, symmetric Zn cells survived up to 5000 h at 1 mA cm−2, and high voltage aqueous zinc ion supercapacitors assembled with Zn anode and activated carbon cathode achieved 800 cycles at 0.1 A g−1. This work provides a feasible approach for constructing high‐voltage alkali metal ion supercapacitors through reconstruction strategy of hydrogen bond network.
The implications of the Madonna/Whore Constellation: A common fantasy underlying misogyny?
Authors: Japko Debra 
Published: August 2023

AbstractThe Madonna/Whore Constellation of fantasies often underlies well‐recognized and pervasive misogynistic attitudes in our culture. These common and disturbing ideas about women serve to validate continued societal acceptance of the degradation of those people who are identified as female. The author suggests that there is a dynamic connection between the often‐unconscious Madonna/Whore complex of fantasies and consciously recognized misogyny. The author suggests that this set of fantasies is driven, in part, by overwhelming (i.e., traumatic) annihilation anxiety. It is argued in this paper that men who have felt overstimulated by women both emotionally and sexually as they develop are likely to feel helpless, anxious, and powerless in relation to women as adults. To defend against these feelings, some men wish for omnipotent control and place women into the binary, dichotomous categories of Madonna or Whore. These fantasies serve to solidify masculine identity and a male sense of superiority. The author proposes that the prevailing norms in our culture that reflect male supremacy not only reflect shared patriarchal beliefs but also function to justify these particularly dangerous hateful beliefs ‐ as if they were appropriate and even necessary to maintaining superior male status.
Overnight urinary melatonin levels in women with and without HIV: An observational cohort study
Authors: Burgess Helen J. , Weber Kathleen M. , Morack Ralph , Yohannes Tsion , Xing Jiaqian , Xue Xiaonan , Gustafson Deborah , Sharma Anjali , Daubert Elizabeth , Rogando Andrea C. , French Audrey L. 
Published: August 2023

AbstractIntroductionDespite significant improvements in longevity and quality of life associated with antiretroviral therapy, individuals with HIV still suffer from a higher burden of sleep and circadian disruption and inflammatory‐based diseases than individuals without HIV. While melatonin is a hormone that has a role in sleep and circadian regulation and has anti‐inflammatory properties, the overnight concentration of the urinary melatonin metabolite has not yet been reported in people with HIV.MethodsThe aim of this study was to compare the overnight urinary melatonin metabolite levels in women aged 35–70 years with HIV (n = 151) to a well‐matched comparison group of women without HIV (n = 147). All women wore a wrist actigraphy monitor and completed daily diaries documenting sleep timing and use of medications and drugs or alcohol for 10 days. Participants collected their overnight urine near the end of the monitoring period.ResultsMelatonin levels did not differ between women with or without HIV, but more than 40% of women had low levels of melatonin. Higher body mass index predicted lower levels of melatonin, and lower levels of melatonin were associated with lower sleep efficiency as assessed with wrist actigraphy.ConclusionThese data lay the foundation for exploration of the longitudinal consequences of endogenous melatonin levels for inflammatory‐based diseases in aging women with and without HIV. Future studies should consider the use of supplemental melatonin to improve sleep in women with lower levels of melatonin.
No reduction in motor‐evoked potential amplitude during the rubber hand illusion
Authors: Reader Arran T. , Coppi Sara , Trifonova Victoria S. , Ehrsson H. Henrik 
Published: August 2023

AbstractIntroductionIn the rubber hand illusion (RHI), touches are applied to a fake hand at the same time as touches are applied to a participant's real hand that is hidden in a congruent position. Synchronous (but not asynchronous) tactile stimulation of the two hands may induce the sensation that the fake hand is the participant's own. As such, the illusion is commonly used to examine the sense of body ownership. Some studies indicate that in addition to the subjective experience of limb ownership reported by participants, the RHI can also reduce corticospinal excitability (e.g., as reflected in motor‐evoked potential [MEP] amplitude) and alter parietal‐motor cortical connectivity in passive participants. These findings have been taken to support a link between motor cortical processing and the subjective experience of body ownership.MethodsIn this study, we tried to replicate the reduction in MEP amplitude associated with the RHI and uncover the components of the illusion that might explain these changes. As such, we used single‐pulse transcranial magnetic stimulation to probe the excitability of the corticospinal motor system as participants experienced the RHI.ResultsDespite participants reporting the presence of the illusion and showing shifts in perceived real hand position towards the fake limb supporting its elicitation, we did not observe any associated reduction in MEP amplitude.ConclusionWe conclude that a reduction in MEP amplitude is not a reliable outcome of the RHI and argue that if such effects do occur, they are unlikely to be large or functionally relevant.
Vav1‐dependent Rac1 activation mediates hypoxia‐induced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF‐1α expression
Authors: Zhu Congyuan , Hu Hao , Ma Ye , Xiong Shuming , Zhu Dongming 
Published: August 2023

AbstractHypoxia has been shown to induce gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC) cells, however, the underlying mechanisms remain to be clarified. In the present study, we investigated whether activation of Vav1/Rac1/HIF‐1α axis is responsible for hypoxia‐induced GEM resistance in PDAC cells. Our results showed that Rac1 activation contributed to hypoxia‐induced GEM resistance in PANC‐1 cells. Hypoxia treatment led to an increased expression level of Vav1, which was responsible for Rac1 activation and GEM resistance in PDAC cells. Furthermore, Rac1 mediated hypoxia‐induced GEM resistance by upregulating HIF‐1α in PDAC cells. Taken together, these findings suggest that hypoxia induces GEM resistance in PDAC cells by activating the Vav1/Rac1/HIF‐1α signaling pathway.
Prevalence of psychiatric disorders among sentenced prisoners in a medium security prison in Ghana: Implications for mental health assessment and service
Authors: Donnir Gordon M. , Asare‐Doku Winifred 
Published: August 2023

AbstractBackgroundExtant literature has shown that there is a higher prevalence of mental disorders among prisoners compared to the general population. These findings have, however, mostly been from high‐income and westernised cultures. In Ghana, little is known about the extent of psychiatric disorders among prisoners, as is consistent with the dearth of scholarly work in low and middle‐income countries.AimsOur aim was to determine the prevalence of common mental disorders among sentenced prisoners in the second largest prison in Ghana.MethodsA cross‐sectional survey research design was used in one prison. The Mini International Neuro‐Psychiatric Interview questionnaire was used to collect data from men and women serving prison sentences who volunteered for the study. Socio‐demographic characteristics and criminal history data were collected using a questionnaire designed by the researchers.ResultsFive hundred prisoners participated. Nearly half (246, 49.8%) had at least one psychiatric disorder. The most prevalent disorders were major depression and a range of anxiety disorders (145, 29%, 132, 26% respectively). A smaller proportion recorded high scores on the antisocial personality disorder scale (13%); just 50 (10%) reported using substances in the 12 months before interview, but this is a minimum estimate of such problems as many were already in prison during that time. None of these prisoners, regardless of disorder, had been screened, diagnosed, or treated in prison.ConclusionsThis study contributes to the gap in scholarly literature in low‐ and middle‐income countries on psychiatric disorders in the prison population. It will be important to explore further the extent to which the internationally recognised screening tools used led to under‐estimation of psychiatric disorders. The findings are of immediate practical importance nationally as they highlight the need to implement reforms anticipated by the new mental health legislation of 2012 and strategies for interagency working to improve health services and their uptake in the criminal justice system.
Long‐term follow‐up after endovascular treatment of aortic coarctation with bare and covered Cheatham platinum stents
Authors: Schleiger Anastasia , Al Darwish Nadim , Meyer Michael , Kramer Peter , Berger Felix , Nordmeyer Johannes 
Published: August 2023

AbstractBackgroundEndovascular treatment of aortic coarctation (CoA) in children and adults frequently requires stent implantation. The aim of this study was to analyze long‐term results after CoA treatment with bare and covered Cheatham‐PlatinumTM (CP) stents in our institution and to derive recommendations for the differential use of these stent types.MethodsIn this retrospective single institution study, 212 patients received endovascular CoA treatment with bare (n = 71) and covered (n = 141) CP stents between September 1999 and July 2021, respectively. The indications for treatment were native CoA in 110/212 patients (51.9%) and re‐coarctation after primary surgical or interventional treatment in 102/212 patients (48.1%). Median patient age at endovascular CoA treatment was 18.8 years [IQR 11.9; 35.8]. Long‐term follow‐up was available in 158/212 patients (74.5%) with a median follow‐up of 7.3 years [IQR 4.3; 12.6].ResultsProcedural success was achieved in 187/212 (88.2%) patients. Survival rate was 98.1% after 5, and 95.6% after 10 and 15 years, respectively. The probability of freedom from re‐intervention was 93.0% after 5, 82.3% after 10 and 77.8% after 15 years, respectively. Freedom from re‐interventions (44/158, 27.8%) did not differ between patients who received bare or covered CP stents (p = 0.715). Multivariable risk factor analysis identified previous CoA surgery (HR: 2.0, 95% confidence interval (CI): 1.1–3,9, p = 0.029), postdilatation (HR: 2,9, 95% CI: 1.1–6.3, p = 0.028) and age at intervention (HR: 0.96, 95% CI: 0.94–0.99, p = 0.002) as independent risk factors for re‐intervention. Peri‐procedural complications occurred in 15/212 (7.1%) patients (dissection/thrombosis of vascular access vessel: n = 9; bleeding: n = 1; stent dislocation: n = 2; aortic dissection/aortic wall rupture: n = 3). Long‐term complications were observed in 36 patients and included stent fracture (n = 19), aneurysm formation (n = 14), endoleak (n = 1) and subclavian artery stenosis (n = 2). Peri‐procedural and long‐term complications did not differ between patients who received CoA treatment with bare or covered CP stents (all p > 0.05).ConclusionEndovascular treatment of CoA using bare or covered CP stents can be performed safely and effectively with excellent long‐term results. Survival, re‐intervention and complication rate did not significantly differ between both stent types. However, individual stent selection is advisable with regard to CoA morphology and severity as well as patient age.
Lyme neuroborreliosis: A case report
Authors: Sayad Babak , Babazadeh Arefeh , Barary Mohammad , Hosseinzadeh Rezvan , Ebrahimpour Soheil , Afshar Zeinab Mohseni 
Published: August 2023

Key Clinical MessageLyme neuroborreliosis is the manifestation of Lyme borreliosis that impacts the nervous system. It gives rise to various neurological and psychiatric conditions, and its diagnosis is challenging. The timely administration of antibiotics is effective.AbstractA male patient, aged 55, was admitted to the emergency department due to the sudden onset of tonic–clonic seizures. All standard laboratory examinations yielded unremarkable outcomes, except a favorable Wright and 2‐mercaptoethanol test. The examination of cerebrospinal fluid revealed the presence of 380 white blood cells per milliliter. The protein level was also elevated, while the glucose level was within the normal range. The results of the serologic tests indicated the presence of both IgG and IgM antibodies to Borrelia burgdorferi. Following the administration of ceftriaxone, a significant improvement was observed in the patient's medical status, and he was subsequently discharged. Lyme neuroborreliosis is the manifestation of Lyme borreliosis that impacts the nervous system. It gives rise to various neurological and psychiatric conditions, and its diagnosis is challenging. The timely administration of antibiotics is effective in treating patients.
Trigeminal trophic syndrome associated with neuralgia after ischemic stroke—a case report
Authors: Rybak‐d′Obyrn Joanna , Alicja Lewandowska Julia , Joanna Machoń Natalia , Agnieszka Owczarczyk‐Saczonek , Waldemar Placek 
Published: August 2023

AbstractTrigeminal trophic syndrome (TTS) is a rare condition resulting from self‐manipulation of the skin after an injury to the trigeminal nerve. We describe the case of a 70‐year‐old woman who was hospitalized because of erythema, ulceration, and crusts on the right side of her face, accompanied by itching, burning, and irritation forcing self‐manipulation of the skin. She had been previously repeatedly treated with antibiotics, acyclovir, and topical medications without any improvement. Her medical history revealed an episode of ischemic stroke in 2016, after which a deformation and partial atrophy of the right ala nasi appeared. Trigeminal neuropathy was confirmed by a neurological consultation. Diagnosis and treatment of TTS requires a multidisciplinary approach. Awareness of this disease should be raised to enable proper diagnosis and management of difficult‐to‐treat facial ulcers that cannot be explained by common causes.
Enhanced Dry Reforming of Methane Catalysis by Ni at Heterointerfaces between Thin MgAlOx and Bulk ZrO2
Authors: Wang Jin , Kayode Gbolade O. , Hirayama Yuki , Shpasser Dina , Ogino Isao , Montemore Matthew M. , Gazit Oz M. 
Published: August 2023

AbstractThe catalytic performance of supported metals is greatly influenced by the interaction with the support material. The role of the support becomes even more important when dealing with metal nanoparticles and high reaction temperatures. Herein, we show that interfacial sites between two metal oxides, MgAlOx and ZrO2 can bestow high stability as well as enhanced reactivity to nickel (Ni) nanoparticles. We use the MgAlOx as thin oxides on an underlying bulk ZrO2. We demonstrate the effect of the metal‐support interactions (MSI) in different support locations on the performance in dry reforming of methane (DRM). We find that the rate of DRM catalysis produces a concave‐down trend with respect to Ni loading with a maximum at ~0.8–1.1 % wt Ni. Measuring the Ni2p3/2 binding energy (BE), we find a similar concave‐down trend whereas for the Mg2p BE we find a concave‐up trend with respect to the Ni loading both with the maximum and minimum centered at 0.8–1.1 % wt Ni, respectively. These trends were correlated with the stability of Ni calculated by DFT. Overall, our results suggest that heterointerfacial sites can be used to tailor moderate MSI, which can be used in the design of DRM catalyst with significantly increased activity and high stability.
Chemoenzymatic Synthesis of Chiral Building Blocks Based on the Kinetic Resolution of Glycerol‐Derived Cyclic Carbonates
Authors: Terazzi Constanza , Spannenberg Anke , von Langermann Jan , Werner Thomas 
Published: August 2023

AbstractThe biocatalytic kinetic resolution of cyclic carbonates derived from glycerol is reported. A selection of 26 esterases and lipases was tested for the asymmetric hydrolysis of the model substrate (epichlorohydrin carbonate) in aqueous medium. Among them, Pig Liver Esterase and Novozym® 435 showed the best selectivity with E=38 and 49, respectively. Both enzymes were employed for the conversion of 12 glycerol derivatives under optimized conditions. The resolution of halogenated carbonates afforded the unconverted enantiomer in up to >99 : 1 er. Furthermore, Novozym® 435 was successfully recycled 10 times without significant loss of activity. Upscaling and isolation of the chiral carbonate was also demonstrated. Subsequent conversion of this chiral building block allowed the direct one‐pot synthesis of (S)‐Guaifenesin, (S)‐Mephenesin and (S)‐Chlorphenesin in up to 89 % yield and 94 : 6 er.
Visible Light and Triselenium Dicyanide (TSD): New Horizons in the Synthesis of Organic Selenocyanates
Authors: Anghinoni João M. , Ferreira Sabrina S. , Piquini Paulo C. , Iglesias Bernardo A. , Perin Gelson , Penteado Filipe , Lenardão Eder J. 
Published: August 2023

AbstractHerein, we describe a new method for the synthesis of α‐carbonyl selenocyanates by reacting triselenium dicyanide (TSD) and styrenes under blue light irradiation and O2 atmosphere. The reactions are triggered by the formation of Se‐centered radical species, followed by the addition/oxidation of the styrene π‐bond. α‐Carbonyl selenocyanates and α‐hydroxy selenocyanates were obtained in moderate to excellent yields from aryl‐ and alkyl‐substituted alkenes, respectively. It was demonstrated that α‐carbonyl selenocyanates could be used as a synthetic platform in a multicomponent reaction strategy to prepare 2‐phenylimidazo[1,2‐a]pyridine derivatives, which were evaluated for their photophysical properties. Overall, this new method provides a useful tool for synthesizing α‐carbonyl selenocyanates, and demonstrates their potential for use in the synthesis of other compounds, thus giving new synthetic opportunities to construct organic selenocyanate compounds.