bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and risk factors of suicide and suicidal ideation in veterans who served in the British Armed Forces: a systematic review
Authors: Randles Rebecca , Burroughs H , Green N , Finnegan A 
Published: June 2023

IntroductionResearch into the factors resulting in suicide in the military veteran population has yet to reach a consensus. Available research is concentrated on a small number of countries, and there is a lack of consistency with contradictory conclusions. The USA has produced a significant amount of research in a country where suicide is identified as a national health crisis, but in the UK, there is little research regarding veterans from the British Armed Forces.MethodsThis systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Corresponding literature searches were conducted in PsychINFO, MEDLINE and CINAHL. Articles that discussed suicide, suicidal ideation, prevalence or risk factors among British Armed Forces veterans were eligible for review. A total of 10 articles met the inclusion criteria and were analysed.ResultsVeterans' suicide rates were found to be comparable to those of the general UK population. The method of suicide used was most commonly found to be hanging and strangulation. Firearms was recorded in 2% of suicide cases. Demographic risk factors were often contradictory with some research stating that there was risk in older veterans and some in younger. However, female veterans were found to be at higher risk than female civilians. Those who had deployed on combat operations were at lower risk of suicide, with research finding that veterans who took longer to seek help for mental health (MH) difficulties reported more suicidal ideation.ConclusionsPeer-reviewed research publications have revealed that UK veteran suicide prevalence is broadly comparable to the general population while highlighting differences across international armed forces. Veteran demographics, service history, transition and MH have all been identified as potential risk factors of suicide and suicidal ideation. Research has also indicated that female veterans are at higher risk than that of their civilian counterparts due to veterans being predominantly male; this could skew results and requires investigation. Current research is limited and further exploration of suicide prevalence and risk factors in the UK veteran population is required.
Critical raw materials associated with the lateritic bauxite and red mud in West Kalimantan, Indonesia
Authors: Hakim Andy Yahya Al , Sunjaya Dedi , Hede Arie Naftali Hawu , Indriati Teti , Hidayat Taufiq 
Published: June 2023

The Western Indonesia Bauxite Province in Kalimantan is a lateritic bauxite region with a complex history and poorly known sustainable metal contents within the bauxite residue. Bauxite residue produced using the Bayer process contains, notably, scandium. We present new geochemical, mineralogical and geological data from the lateritic bauxite and red mud from the active mine and deposit, which allow us to investigate the behaviour of critical elements during weathering. The geochemical analysis and translated isocon results have shown that the content of scandium in red mud is higher than the average concentration of crustal rocks and is concentrated in the ferrite layer and bauxite residue. A positive correlation between the existence of iron oxyhydroxide mineral in the residual iron-rich layer and red muds with the rare earth elements (REEs) and scandium concentrations may be interpreted as a scavenging effect of mobile REEs. The weathering and leaching processes in bauxite allows the adsorption of the trivalent scandium cation (Sc
3+
) on goethite and are followed by ionic substitution with other trivalent cations in crystals of hematite. The study illustrates the importance of understanding processes during weathering and laterization for geochemical processes and REE exploration in tropical areas.

Supplementary material:
Material A, (A) Mineralogical profile of the bauxite, ferrite, and tonalite in Tayan and Mempawah, (B) Ternary diagram of bauxite and their parent rocks, (C) Trace element ratios in bauxite; Material B, Spearman's correlation rank of bauxite and associated rocks from Tayan mine (
n
= 35); Material C, (A) XRD patterns of representative samples from the Tayan mine and Mempawah deposit, West Kalimantan, (B) Typical normal (left) and continuum (right) removed reflectance spectral curves of samples are available at
https://doi.org/10.6084/m9.figshare.c.6689139

Thematic collection:
This article is part of the Geochemical processes related to mined, milled, or natural metal deposits collection available at:
https://www.lyellcollection.org/topic/collections/geochemical-processes-related-to-mined-milled-or-natural-metal-deposits
Noncollinear Equilibrium Points in CRTBP with Yukawa-Like Corrections to Newtonian Potential under an Oblate Primary Model
Authors: Idrisi M. Javed , Haruna Sunusi , Eshetie Teklehaimanot 
Published: June 2023

This study is about the effects of Yukawa-like corrections to Newtonian potential on the existence and stability of noncollinear equilibrium points in a circular restricted three-body problem when bigger primary is an oblate spheroid. It is observed that ∂x0/∂λ = 0 = ∂y0/∂λ at λ0 = 1/2, so we have a critical point λ0 = 1/2 at which the maximum and minimum values of x0 and y0 can be obtained, where λ ∈ (0, ∞) is the range of Yukawa force and (x0, y0) are the coordinates of noncollinear equilibrium points. It is found that x0 and y0 are increasing functions in λ in the interval 0 < λ < λ0 and decreasing functions in λ in the interval λ0 < λ < ∞ for all α ∈ α+. On the other hand, x0 and y0 are decreasing functions in λ in the interval 0 < λ < λ0 and increasing functions in λ in the interval λ0 < λ < ∞ for all α ∈ α−, where α ∈ (−1, 1) is the coupling constant of Yukawa force to gravitational force. The noncollinear equilibrium points are found linearly stable for the critical mass parameter β0, and it is noticed that ∂β0/∂λ = 0 at

λ

∗

= 1/3; thus, we got another critical point which gives the maximum and minimum values of β0. Also, ∂β0/∂λ > 0 if 0 < λ <

λ

∗

and ∂β0/∂λ < 0 if

λ

∗

< λ < ∞ for all α ∈ α−, and ∂β0/∂λ < 0 if 0 < λ <

λ

∗

and ∂β0/∂λ > 0 if

λ

∗

< λ < ∞ for all α ∈ α+. Thus, the local minima for β0 in the interval 0 < λ <

λ

∗

can also be obtained.
N
6-methyladenosine Modification of FZR1 mRNA Promotes Gemcitabine Resistance in Pancreatic Cancer
Authors: Su Jiachun , Li Rui , Chen Ziming , Liu Shaoqiu , Zhao Hongzhe , Deng Shuang , Zeng Lingxing , Xu Zilan , Zhao Sihan , Zhou Yifan , Li Mei , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Zhang Shaoping , Chen Rufu , Huang Xudong , Lin Dongxin , Zheng Jian , Zhang Jialiang 
Published: June 2023

Abstract

The therapeutic options for treating pancreatic ductal adenocarcinoma (PDAC) are limited, and resistance to gemcitabine, a cornerstone of PDAC chemotherapy regimens, remains a major challenge. N6-methyladenosine (m6A) is a prevalent modification in mRNA that has been linked to diverse biological processes in human diseases. Herein, by characterizing the global m6A profile in a panel of gemcitabine-sensitive and gemcitabine-insensitive PDAC cells, we identified a key role for elevated m6A modification of the master G0–G1 regulator FZR1 in regulating gemcitabine sensitivity. Targeting FZR1 m6A modification augmented the response to gemcitabine treatment in gemcitabine-resistant PDAC cells both in vitro and in vivo. Mechanistically, GEMIN5 was identified as a novel m6A mediator that specifically bound to m6A-modified FZR1 and recruited the eIF3 translation initiation complex to accelerate FZR1 translation. FZR1 upregulation maintained the G0–G1 quiescent state and suppressed gemcitabine sensitivity in PDAC cells. Clinical analysis further demonstrated that both high levels of FZR1 m6A modification and FZR1 protein corresponded to poor response to gemcitabine. These findings reveal the critical function of m6A modification in regulating gemcitabine sensitivity in PDAC and identify the FZR1–GEMIN5 axis as a potential target to enhance gemcitabine response.

Significance:
Increased FZR1 translation induced by m6A modification engenders a gemcitabine-resistant phenotype by inducing a quiescent state and confers a targetable vulnerability to improve treatment response in PDAC.
Nanoparticle-Based Combination Therapy Enhances Fulvestrant Efficacy and Overcomes Tumor Resistance in ER-Positive Breast Cancer
Authors: Li Bozhao , Qi Feilong , Zhu Fei , Lu Zefang , Wang Meiqi , Chu Tianjiao , Wu Suying , Wei Jingyan , Song Zhenchuan , Sukumar Saraswati , Zhang Cheng , Xu Jiangfei , Li Suping , Nie Guangjun 
Published: June 2023

Abstract

Nanoparticles (NP) spanning diverse materials and properties have the potential to encapsulate and to protect a wide range of therapeutic cargos to increase bioavailability, to prevent undesired degradation, and to mitigate toxicity. Fulvestrant, a selective estrogen receptor degrader, is commonly used for treating patients with estrogen receptor (ER)–positive breast cancer, but its broad and continual application is limited by poor solubility, invasive muscle administration, and drug resistance. Here, we developed an active targeting motif-modified, intravenously injectable, hydrophilic NP that encapsulates fulvestrant to facilitate its delivery via the bloodstream to tumors, improving bioavailability and systemic tolerability. In addition, the NP was coloaded with abemaciclib, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), to prevent the development of drug resistance associated with long-term fulvestrant treatment. Targeting peptide modifications on the NP surface assisted in the site-specific release of the drugs to ensure specific toxicity in the tumor tissues and to spare normal tissue. The NP formulation (PPFA-cRGD) exhibited efficient tumor cell killing in both in vitro organoid models and in vivo orthotopic ER-positive breast cancer models without apparent adverse effects, as verified in mouse and Bama miniature pig models. This NP-based therapeutic provides an opportunity for continual and extensive clinical application of fulvestrant, thus indicating its promise as a treatment option for patients with ER-positive breast cancer.

Significance:
A smart nanomedicine encapsulating fulvestrant to improve its half-life, bioavailability, and tumor-targeting and coloaded with CDK4/6 inhibitor abemaciclib to block resistance is a safe and effective therapy for ER-positive breast cancer.
“Remember!”
Authors: Janssen-Wnorowska Arnim 
Published: June 2023

Abstract
By discussing some text-critical findings, this article poses the question of how the concept of emotivity can inform our understanding of the transmission processes which shaped Lam 1. An introduction establishes the theoretical and methodological basis for a comparative analysis of the Masoretic text, the Qumran manuscript of 4QLam, and Targum Lamentations. In various ways, the textual witnesses intensify and emotionalize Lam 1. Moreover, they focus on specific emotion words and make their meaning explicit for readers and listeners. Finally, the textual witnesses use different means to allow recipients to identify with the emotional descriptions.
A new species of pilumnid crab of the genus Vellumnus Ng, 2010 (Brachyura, Pilumnoidea) from the Persian Gulf
Authors: Fahimi Neda , Naderloo Reza 
Published: June 2023

Abstract
A new species of Vellumnus Ng, 2010 (Pilumnidae) is described from coral debris in the Persian Gulf. It differs from its closest congeners by the carapace sculpture, presence of two fissures on the supraorbital margin, the structure of the frontal lobes that are continuous with the inner-orbital angle, and the pattern of the granules on the outer surface of the chela.
Discourse Structure and Argument Realisation in Old Literary Tibetan: From Text Composition to Verb Semantics
Authors: Bialek Joanna 
Published: June 2023

Abstract
The paper discusses disparate language phenomena whose common denominator is their relevance for the study of argument realisation in Old Literary Tibetan. It attempts to outline the boundaries, within which argument realisation should be considered when preparing a verb lexicon, dictionary, or a syntactic annotation of a text. The study focuses on processes and constructions that may have impact on argument realisation of verbs and belong to discourse-forming strategies of the language. In a top-down approach various levels of text composition are examined for their role in presentation of events.
The Structure of the Noun Phrase in Northern and Southern Ewenki Dialects
Authors: Däbritz Chris Lasse 
Published: June 2023

Abstract
The paper investigates the structure of Ewenki noun phrases, dealing with both their semantics and syntax. Whereas semantics are rather uniform cross-dialectally, there is considerable variation in syntax, especially regarding agreement patterns. As a rule, the more northern a dialect is the less agreement it exhibits within the noun phrase; besides that, cardinal numerals greater or equal to ‘2’ call for the modified noun in plural in rather Southern dialects, but for its unmarked form in rather Northern dialects. From a comparative point of view, it can be shown that the areal-typologically unexpected agreement within the noun phrase is probably the inherited pattern in (Northern) Tungusic languages, whereas the relevant Ewenki dialects lost it secondarily due to Turkic (Dolgan and Sakha) influence.
Mitigation Strategies in Colloquial Conversations: A Contrastive Approach in European, Cuban, Mexican, Argentinian and Chilean Spanish
Authors: Marco Marta Albelda 
Published: June 2023

Abstract
This paper compares the pragmatic mitigation strategies used by speakers of five geographic varieties of Spanish: European, Cuban, Mexican, Argentinian and Chilean Spanish. Mitigation can be understood as a pragmatic strategy arising from face-protection needs that seeks to reduce possible adverse effects on the satisfactory progress of communication.
The data are drawn from the Ameresco corpus of colloquial conversations, and the analysis includes four kinds of parameters: linguistic, pragmatic, and socio-situational. The study explores the functions and frequency of use of mitigation, speakers’ and hearers’ exposure to social and relational risks, the degree of their commitment in interaction, and the most productive resources observed in each variety.
The results show convergences and divergences in the use of mitigation in these geographical areas, providing a picture of dialectal and sociolectal patterns here. The study concludes that mitigation varies according to the priorities of face needs in each speech community.
Diagnosis of Antarctic Blowing Snow Properties Using MERRA-2 Reanalysis with a Machine Learning Model
Authors: Yang Yuekui , Kiv Daniel , Bhatta Surendra , Ganeshan Manisha , Lu Xiaomei , Palm Stephen 
Published: June 2023

Abstract
This paper presents work using a machine learning model to diagnose Antarctic blowing snow (BLSN) properties with the Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), data. We adopt the random forest classifier for BLSN identification and the random forest regressor for BLSN optical depth and height diagnosis. BLSN properties observed from the Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) are used as the truth for training the model. Using MERRA-2 fields such as snow age, surface elevation and pressure, temperature, specific humidity, and temperature gradient at the 2-m level, and wind speed at the 10-m level as input, reasonable results are achieved. Hourly blowing snow property diagnostics are generated with the trained model. Using 2010 as an example, it is shown that the Antarctic BLSN frequency is much higher over East than West Antarctica. High-frequency months are from April to September, during which BLSN frequency exceeds 20% over East Antarctica. For May 2010, the BLSN snow frequency in the region is as high as 37%. Due to the suppression by strong surface-based inversions, larger values of BLSN height and optical depth are usually limited to the coastal regions, wherein the strength of surface-based inversions is weaker.
Seasonal Effects of the Tibetan Plateau on Cyclonic Transient Eddies: A System-Centered View
Authors: Ren Qiaoling , Hodges Kevin I. , Schiemann Reinhard , Dai Yongjiu , Jiang Xingwen , Yang Song 
Published: June 2023

Abstract
Using an objective feature-tracking algorithm and the fifth major global reanalysis produced by ECMWF data (ERA5), the seasonal behaviors of cyclonic transient eddies (cyclones) at different levels around the Tibetan Plateau (TP) were examined to understand the effects of the TP on cyclones. Results show that the TP tends to change the moving directions of the remote cyclones when they are close to the TP, with only 2% of the 250-hPa eastward-moving cyclones directly passing over the TP. The sudden reductions of their moving speeds and relative vorticity intensities around the TP suggest a suppression effect of the plateau. Over 70% of these cyclones perish over the TP regardless of the altitude. This percentage decreases to around 65% during summertime, exhibiting a weaker summer suppression effect. On the other hand, the TP has a stimulation effect on local cyclones through its dynamic forcing in winter, thermodynamic forcing in summer, and both forcings in the transitional seasons. The numbers of locally generated cyclones, especially at 500 hPa, just above the TP, are significantly larger than those of the remote cyclones during all seasons. Although about one-half of the local cyclones dissipate over the TP, the cyclones moving off the plateau significantly outnumber the moving-in cyclones, with the differences ranging from 0 to 6 cyclones per month. Only the 250-hPa wintertime moving-off cyclones are fewer than the cyclones entering the TP, which may be caused by the weaker stimulation effect and stronger suppression effect of the TP on the wintertime upper-level cyclones.

Significance Statement
Cyclonic transient eddies (cyclones), steered by westerly jet streams, can influence climate and induce extreme weather processes under certain conditions. The Tibetan Plateau (TP), the highest and largest obstacle embedded in the westerly jet streams, suppresses remote cyclones entering the TP region, destroying over 70% of these cyclones. However, because of the excitation effect of the TP on local cyclones, the numbers of cyclones moving off the TP are still larger than or equal to those of the moving-in cyclones, except at the upper levels in winter. This feature suggests that the TP cannot significantly decrease the total cyclone numbers in most cases, but it indeed weakens the mean intensity and moving speed of the cyclones.
Effect of Dupilumab on Type 2 Biomarkers in Chronic Rhinosinusitis With Nasal Polyps: SINUS-52 Study Results
Authors: Bachert Claus , Laidlaw Tanya M. , Cho Seong H. , Mullol Joaquim , Swanson Brian N. , Naimi Souad , Classe Marion , Harel Sivan , Jagerschmidt Alexandre , Laws Elizabeth , Ruddy Marcella , Praestgaard Amy , Amin Nikhil , Mannent Leda P. 
Published: June 2023

Objectives: Chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and non-steroidal anti-inflammatory drug-exacerbated respiratory disease (NSAID-ERD) are frequent coexisting conditions and share type 2 inflammatory pathophysiology, with interleukin (IL)-4 and IL-13 as key cytokines. Dupilumab is a monoclonal antibody that blocks the shared receptor for IL-4 and IL-13. The objective of this analysis was to evaluate dupilumab’s effect on type 2 inflammation biomarkers in patients with CRSwNP with/without coexisting asthma or NSAID-ERD from the SINUS-52 (NCT02898454) study. Methods: Patients received treatment with dupilumab or placebo for 52 weeks. Blood and urinary biomarkers were evaluated through 52 weeks, and nasal secretions and mucosa brushings through 24 weeks. Results: Of 447 patients, 60% had coexisting asthma and 27% had coexisting NSAID-ERD. At baseline, blood eotaxin-3, eosinophils, and periostin, nasal secretion eotaxin-3, and urinary leukotriene E4 were significantly higher in patients with coexisting NSAID-ERD than without. Dupilumab reduced eotaxin-3, thymus and activation-regulated chemokine, periostin, and total immunoglobulin E in blood, eotaxin-3, periostin, IL-5, and eosinophil cationic protein in nasal secretions, and leukotriene E4 in urine. Reductions were generally similar or greater in the subgroups with asthma and NSAID-ERD than without. Dupilumab also reduced MUC5AC and mast cell counts in nasal mucosa brushings. Conclusion: Dupilumab reduced local and systemic type 2 inflammatory biomarkers in patients with CRSwNP, including mast cells in nasal mucosa and cysteinyl leukotrienes in urine. These findings provide insight into the processes driving CRSwNP and the mechanisms of dupilumab’s therapeutic effects. Clinical Trial Registry Name: SINUS-52 https://www.clinicaltrials.gov/ct2/show/NCT02898454 ClinicalTrials.gov Identifier: NCT02898454
Outcomes and Management of Infants Who Refer Newborn Hearing Screening
Authors: Schild Sam D. , Mendelsohn Matthew A. , Plum Ann , Goldstein Nira A. 
Published: June 2023

Objectives: With the implementation of Universal Newborn Hearing Screening, early diagnosis and referral has been expedited. Many patients who refer screening pass subsequent testing with otoacoustic emissions (OAE) or auditory brainstem response (ABR). The objective of our study was to identify the incidence and etiology of hearing loss in infants who refer initial testing in an urban, tertiary care pediatric otolaryngology practice. Methods: We performed a chart review of infants who were evaluated after referring newborn hearing screening from 2017 to 2021. Data collected included birth history, hospital screening results, subsequent audiology and otolaryngology visit findings, final hearing diagnoses, interventions, and outcomes. Results: Of the 450 patients, 83.8% (n = 377) had normal hearing bilaterally after repeat testing (OAE and/or ABR). Thirty five patients were diagnosed with otitis media with effusion (OME) (7.8%) and 17 patients (3.8%) were diagnosed with sensorineural hearing loss. Twenty seven patients (6.0%) were diagnosed with obstructing cerumen/vernix, many times in addition to another diagnosis. Of the 17 patients with sensorineural hearing loss, 2 had genetic syndromes and 2 had congenital cytomegalovirus. Sensorineural hearing loss was significantly associated with the presence of a deafness syndrome ( P = .004) and in-utero infections ( P = .04). About 11 (2.4%) underwent myringotomy with tube placement, 5 (1.1%) were fitted with hearing aids, 2 (0.4%) were referred for hearing aids, 4 (0.9%) had both myringotomy with tube placement and hearing aids, 1 child had a soft band/Bone Anchored Hearing Aid (BAHA) (0.2%), and 1 child (0.2%) had a cochlear implant. Conclusion: Our incidence of sensorineural hearing loss was 3.8% (95% CI 2.0, 5.5), compared to rates of 0.44 to 68% in the published literature. Most patients had normal hearing, usually identified after only 1 repeat test. OME requiring myringotomy tube insertion was the most common pathology requiring intervention. Close observation for resolution and intervention, if warranted, is critical to prevent sequelae.