bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis
Authors: Gareeballah Awadia , Gameraddin Moawia , Alshoabi Sultan Abdulwadoud , Alsaedi Amirah , Elzaki Maisa , Alsharif Walaa , Daoud Ibrahim Mohamed , Aldahery Shrooq , Alelyani Magbool , AbdElrahim Elrashed , Alhazmi Fahad H. , Hamd Zuhal Y. , Ahmed Abouraida Raga , Khandaker Mayeen Uddin , Adam Mohamed 
Published: January 2025

IntroductionAdnexal masses are a common health issue in gynecology; the challenge lies in the differential diagnosis of these masses. The International Ovarian Tumor Analysis Simple Rules (IOTA-SR) offers the first scoring system to aid in diagnosis. It is based on a set of five ultrasound imaging features indicative of a malignant ovarian tumor and five features indicative of a benign tumor. This review aims to assess the diagnostic performance of IOTA-SR for classifying ovarian tumors as benign or malignant.MethodsA systematic review was conducted on MEDLINE, Embase, Google Scholar, Scopus, and Web of Science. The terminologies “IOTA-SR”, “adnexal, mass”, and “ovarian tumors scoring” were employed. Twenty-seven research articles conducted from 2008 to 2022 were included in the meta-analysis; the publication outcome indicates that performance quality tests were extracted directly or indirectly, including true positive (TP), false positive (FP), true negative (TN), and false negative (FN). The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was used to evaluate the study quality and estimate the risk of bias. After estimating the pooled effect of the sensitivity, specificity, and diagnostic odds ratio (DOR), the summary receiver operating characteristic (SROC) curve was estimated using the bivariate random effects model. Utilizing Cochran’s Q statistics and Higgins’s inconsistency test through the I2 index for pooled analysis, the heterogeneity of studies was quantitatively evaluated. The funnel plot and Egger’s test were utilized to visually and quantitatively evaluate potential publication bias.ResultsAmong 27 studies, including 7,841 adnexal masses, the results of this meta-analysis showed excellent diagnostic performance with a pooled sensitivity of 92% [95% confidence interval (CI), 0.89–0.94] and a pooled specificity of 92% (95% CI, 0.89–0.94). The IOTA-SR was applicable in 85.7% of adnexal masses.ConclusionThe IOTA-SR is highly effective in the presurgical differentiation of malignant versus benign adnexal masses when applied by an expert ultrasonography operator.
Dual-positive gastric cancer: an extremely malignant subtype of gastric cancer with high serum alpha-fetoprotein and carcinoembryonic antigen concentrations
Authors: Xie Weixun , Hu Chengyu , Liu Hongming , Wu Zelai , Luo Bixian , Wu Xiaoying , Tuo Chuanlei , Deng Ziyin , Liang Han , Liu Yong , Gong Weihua 
Published: January 2025

BackgroundAlpha-fetoprotein-producing gastric cancer (AFPGC) is a highly malignant subtype of gastric cancer, but solely alpha-fetoprotein may fail to accurately predict the prognosis. Although the utilization of multi tumor markers could improve stratified patient management, such research in AFPGC is still blank. This study seeks to evaluate whether combining multiple tumor markers can enhance risk stratification and identify AFPGC subtypes with poor prognosis.MethodsWe first screened for patients with elevated serum CEA levels within the AFPGC cohort and evaluated their prognosis. Tumor characteristics and overall health conditions were analyzed to identify factors contributing to CEA elevation. Finally, the treatment responses of this group to different treatment modalities were also reviewed.ResultsApproximately 45% of gastric cancer patients with elevated serum AFP also show increased CEA levels, classifying them as the dual-positive gastric cancer (DPGC) subgroup. These patients exhibit significantly shorter overall survival, heightened metastasis risk, and are more susceptible to systemic inflammation, immune response dysregulation, malnutrition, and cancer-related thrombosis. The elevation in serum CEA levels may indicate gastric cancer liver metastasis and increased neutrophils. While surgery is optimal for AFPGC, DPGC patients benefit significantly from immunotherapy combined with chemotherapy.ConclusionsIn AFPGC, combining serum AFP and CEA offers a more accurate prognosis. The poor prognosis in DPGC may be associated with aggressive local properties and systemic complications. Liver metastases and increased neutrophils are associated with increased serum CEA in AFPGC. Immunochemotherapy is a viable option for DPGC patients who cannot undergo surgery.
Case report: Short-course hypofractionated radiation therapy combined with immune checkpoint inhibitors for the treatment of advanced ovarian mucinous cystadenocarcinoma
Authors: Wan Xinan , Fang Mingxing , Yuan Le , Zhang Hang , Wang Dan 
Published: January 2025

BackgroundOvarian mucinous cystadenocarcinoma is a rare subtype of ovarian epithelial carcinoma that is resistant to platinum-based chemotherapy and has a poor prognosis, and there is no standard treatment plan for patients for whom multiline treatment has failed.Case presentationoma with FIGO stage IVB disease who was sequentially treated with paclitaxel liposomes+carboplatin, 5-Fu+CF+oxaliplatin, capecitabine+oxaliplatin, bevacizumab+FOLFOX4, S-1, and bevacizumab+oxaliplatin+raltitrexed chemotherapy. After the progression of the disease, a combination of short-course hypofractionated radiation therapy and immune checkpoint inhibitors was used. The radiotherapy target area was the metastatic lymph nodes in the right posterior part of the hepatic artery, with a radiation dose of 30 Gy/10 F. Camrelizumab, an immune checkpoint inhibitor, was administered intravenously every three weeks at a dose of 200 mg each time. The therapeutic effect was significant, with CA125 levels within the normal range. Metastatic lymph nodes disappeared from the abdominal cavity. The therapeutic effect achieved a complete response (CR). Currently, CA125 levels are within the normal range, and abdominal CT reveals no tumor recurrence or metastasis. The duration of response (DoR) reached over four years.ConclusionOvarian mucinous cystadenocarcinoma is a rare tumor with poor treatment efficacy and poor prognosis. Short-course hypofractionated radiation therapy combined with PD-1 inhibitors may be an effective and safe treatment strategy.
Prevalence and predictors of short stature in children aged 3–18 years in Hainan Province, China: a cross-sectional study
Authors: Yan Mi , Qin Yingying , Li Hongai , Huang Chuican , Li Haidan , Liu Li , Cai Yuhua , Fan Lichun , Xiang Wei , Huang Xiaoyan 
Published: January 2025

BackgroundShort stature is a global health-related problem and remains to be evaluated in children in Hainan Province. The present study was conducted to investigate the associated factors with short-stature in children.MethodsThis cross-sectional study was conducted using a staged, cluster random sampling method. A total of 26,189 children aged 3–18 years, originating from 18 cities and counties in Hainan Province, to determine the prevalence of short stature. Additionally, these children were selected for a thorough analysis of associated factors.ResultsThe crude prevalence of short stature was 2.88%, and the standard prevalence was (after adding weights) 3.01%. Children's short stature was significantly related to seven factors: area, birth weight, body mass index z score (BAZ), maternal education, family income (RMB per year), frequency of bean intake and frequency of egg intake. A nomogram model of factors associated with short stature was constructed. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was 0.698 (95% CI: 0.679–0.716).ConclusionsOur findings demonstrated that birth weight, BAZ, dietary habits, and family-related factors were strongly correlated with short stature in children in Hainan Province.
Use of rituximab in mature, high-grade and advanced-stage pediatric B-lineage non-Hodgkin lymphomas: a systematic review, meta-analysis and the Brazilian reality
Authors: Castro Alejandra Adriana Cardoso de , Oliveira Liana Alves de , Andrade Diancarlos Pereira de , Carbone Edna Kakitani , Rosati Roberto 
Published: January 2025

ObjectivesRituximab is a valuable agent for treating adult B-cell non-Hodgkin lymphoma (B-NHL), and several studies have tested its efficacy in children with mature, high-grade B-NHL. The aim of the present study was to systematically review the use of rituximab in children and adolescents with high-grade mature B-NHL and to conduct a meta-analysis of the evidence. Since access to this medication in public health systems in low- and middle-income countries is complex, we were also interested in mapping access to it in Brazil.MethodsWe conducted a systematic review and meta-analysis on the survival of pediatric patients with mature, high-grade and advanced-stage B-NHL treated with rituximab in combination with chemotherapy in first-line treatment or later. Patients' access to the medication was evaluated through a questionnaire sent to oncologists in Brazilian pediatric oncology centers.ResultsWe selected 17 trials, which were subsequently grouped by disease type and line of therapy. In patients receiving first-line treatment, excluding those with primary mediastinal B-cell lymphoma (PMBL), the use of rituximab resulted in (1) better event-free survival [Hazard Ratio of 0.37 (0.22, 0.61); p &lt; 0.01]; (2) a reduced risk of events [odds ratio of 0.44 (0.26–0.76); p = 0.003]; and (3) a reduced risk of death [odds ratio of 0.44 (0.21–0.89); p = 0.02]. In refractory or relapsed (R/R) patients, rituximab use was associated with a decreased chance of death [odds ratio of 0.25 (0.09–0.75); p = 0.01]. Additionally, our survey included 31 Brazilian centers, 63% of which reported bearing the cost of rituximab.ConclusionRituximab improves outcomes in pediatric patients receiving first-line treatment for high-grade B-NHL (except PBML) and overall survival in R/R patients. However, access to rituximab in Brazilian hospitals is currently dependent on centers supporting its economic burden.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42021292912).
Nicotine’s impact on platelet function: insights into hemostasis mechanisms
Authors: Wu Xiayu , Liu Yongjun , Zou Changhao , He Fuqin , Guo Fang , Liu Sijia , Fan Yi , Zhu Xuedong , Zhou Qianyi , Shu Dan 
Published: January 2025

IntroductionTraditional Miao and Dai Chinese medicines have used nicotine-rich leaf tobacco to treat traumatic injuries by promoting hemostasis. While nicotine is known to enhance platelet aggregation, its effects on other platelet functions and underlying mechanisms remain unclear.Methods and ResultsThis study aimed to thoroughly investigate nicotine’s effects on human platelets and its pharmacological mechanisms, using thromboelastography to assess nicotine’s impact on platelet function during coagulation. This study aimed to investigate the functional effects of nicotine on human platelets and elucidate its pharmacological mechanisms. The impact of nicotine on platelet function during the coagulation process was assessed using thromboelastography. Further studies showed that nicotine fully activates washed platelets, promoting aggregation, granule release, adhesion, spreading, and plaque retraction. Concurrently, nicotine was found to enhance the intracellular concentration of calcium ions in platelets ([Ca2+]i). To explore the underlying mechanisms, molecular docking software was employed to identify the platelet membrane receptors PAR1 and PAR4, which exhibited the highest docking scores with nicotine. Intervention with two receptor inhibitors demonstrated that only the PAR4 inhibitor could reverse the stimulatory effects of nicotine on platelet granule release. Through the examination of alterations in the downstream signaling pathways of PAR4 receptors, it was determined that nicotine promo-facilitates the phosphorylation of PI3K, AKT, and ERK1/2 proteins, subsequently contributing to the activation of αIIbβ3 receptors in platelets. Conversely, the application of PAR4 inhibitors was found to reverse these effects.DiscussionIn conclusion, nicotine activates αIIbβ3 receptors and significantly enhances platelet function by promoting the phosphorylation of the platelet PAR4 receptor signaling pathway. These findings suggest the potential utility of nicotine as a hemostatic agent.
Sexual dimorphism for juvenile body weight in chickens divergently selected for 8-week body weight
Authors: Siegel Paul B. , Honaker Christa F. 
Published: January 2025

There is a dearth of literature on the genetics of sexual dimorphism for juvenile body weight in meat-type chickens given its biological and economic relevance. Herein, we report the sexual dimorphism for 4- and 8-week body weights in White Plymouth Rock chicken lines that have undergone 67 generations of selection. Fluctuations in the degree of dimorphism occurred across generations, with greater dimorphism and less variation at 8 weeks than 4 weeks. Over the 67 generations, there was a significant decrease in the degree of dimorphism in the high line, with no changes in the low line. It is very difficult to genetically modify sexual dimorphism in a particular population using the currently available conventional tools, and nature possesses homeostatic mechanisms that maintain stasis in a population.
The relationship between work-life balance and psychological well-being: an empirical study of metro rail travelers working in the information technology sector
Authors: Prasad K. D. V. , Rao Mruthyanjaya , Vaidya Rajesh , Sriyogi Kottala , Singh Shivoham , Srinivas Ved 
Published: January 2025

ObjectivesTo investigate the relationship between work–life balance and the psychological well-being of metro rail travelers working in the information technology sector. The study also examined occupational stress as a pathway between work-life balance and psychological well-being. The study also investigated the impact of occupational stress and work–life balance on the psychological well-being of metro travelers who work in the information technology sector, modeling lower- and higher-order constructs.MethodsA quantitative survey method was used, and the data were gathered from information technology employees who frequently travel on Metro Rail to commute to the office and return home when the COVID-19 pandemic peaked in India in 2022. A structured questionnaire was developed, and a link was provided to the IT sector employees visiting almost all the metro stations in Hyderabad, an Indian Metro, to measure 8 reflective constructs. The data were gathered via random sampling, and the questionnaires were randomly distributed to the different IT sector companies. The valid responses of 500 participants were analyzed for structural equation modeling. The eight reflective constructs in the study are occupational stress, the 3 constructs of work–life balance—“work interference with personal life, personal life interference with work and work–personal life enhancement”—and the four constructs of psychological well-being autonomy, self-acceptance, positive relations, and environmental mastery.ResultsThe SEM results for the lower-order constructs indicate that the impact of occupational stress on psychological well-being was statistically significant (p &lt; 0.005), as were the two constructs of psychological well-being, environmental mastery, and self-acceptance (p &lt; 0.001; p &lt; 0.05). With respect to the impact of the work–life balance constructs, the impacts of the WIPL, WPLE, and PLIW work–life balance constructs were statistically significant (p &lt; 0.05; p &lt; 0.001, respectively) for all four psychological well-being constructs. Occupational stress partially mediated the relationship between work–life balance and psychological well-being, as both the direct and indirect effects were statistically significant when the higher-order constructs work–life balance and psychological well-being were tested. The direct effects of occupational stress and work–life balance on psychological well-being are statistically significant (p &lt; 0.05, p &lt; 0.001).ConclusionThe authors suggest framing policies to mitigate occupational stress and enhance the psychological well-being and work–life balance of employees in the information technology sector.
The relationship between nightmares and depression in adolescents: the effect of age and anxiety
Authors: Li Yuhang , Duan Xiaorong , Han Le , Liu Ning , Han Xueyang , Su Mingzhu , Yang Tao , He Sha , Liu Rui , Gao Xinyu , Xie Yutong , Jiang Jie , Yang Laiqi , Xie Bin , Zou Xue 
Published: January 2025

IntroductionNightmares and depression are prevalent issues among adolescents. This study explores the relationship between nightmares and depression, focusing on the mediating role of anxiety and the moderating effect of ageMethodsA total of 210 adolescents aged 13 to 24 were surveyed using the Nightmare Distress Questionnaire (NDQ-CV), Self-Rating Anxiety Scale (SAS), and Self-Rating Depression Scale (SDS). They also underwent niacin skin flushing response (NSFR) testing to explore physiological correlations. A moderated mediation model was applied to assess the relationships between nightmares, anxiety, and depression. Spearman correlation analysis was used to analyze the relationship between nightmares and NSFRResultsNightmares did not directly lead to depression, but anxiety served as a full mediator in this relationship. Age had no significant moderating effect. Additionally, a significant negative correlation between nightmares and NSFR was observedConclusionNightmares contribute to anxiety, which can lead to depression in adolescents, suggesting that clinicians can identify and intervene with nightmares in adolescents to minimize the onset of psychological disorders. The study also highlights a possible connection between nightmares and NSFR, suggesting further research is needed to understand the physiological mechanisms
Association between internet use and depression among the middle-aged and elderly adults with multimorbidity in China: do gender differences exist?
Authors: Zhang Jiao , Jia Yuheng , Hong Lixin , Zhang Yixin , Li Lihua , Tian Kan 
Published: January 2025

ObjectivesInternet use and the results of mental health are related. Numbers of studies presented the association between Internet use and depression, and the middle-aged and elderly adults with multimorbidity are of concern. The study aimed to explore the relationship between Internet use and depression in middle-aged and elderly adults with multimorbidity.MethodsWe selected 2550 respondents aged 45 years and above with multimorbidity from the China Health and Retirement Longitudinal Study (CHARLS) 2018 database. Logistic regression models were constructed to examine the effects of Internet use on depression, as well as comparing gender differences. Meanwhile, propensity score matching (PSM) was used to test the robustness of the results.ResultsOverall, 49.8% of respondents had a risk of developing depression, and 14.9% of the participants used the Internet. Internet use (OR = 0.66, P = 0.002), type of devices (one type: OR = 0.69, P = .011;≥2 types: OR = 0.53, P = 0.03), frequency of Internet use (regularly: OR = 0.67, P = 0.005) were all inversely associated with depression. Significant differences between genders were observed, Internet use was associated with a lower prevalence of depression among men, while the association was not statistically significant among women.ConclusionsThere is a significantly negative association between Internet use and depression in the middle-aged and elderly adults with multimorbidity in China, and this relationship varies across different genders. This suggests that Internet use may be a protective factor for depressive symptoms in the older population, offering a guideline for policymakers to develop specific strategies for different genders.
Sources of polycyclic aromatic hydrocarbons exposure and their effects on glycolipid metabolism in pregnant women and their newborn in Haikou City, China
Authors: Cheng Xiaomei , Gao Haifeng , Li Qiaojun , Zhang Naifan , Lu Ying 
Published: January 2025

BackgroundPolycyclic aromatic hydrocarbons (PAHs) are a class of large organic compounds that persist in the environment and are classified as an important subset of persistent organic pollutants (POPs). This study aimed to assess PAH exposure in pregnant women and newborns in Haikou City, China, and evaluate their impact on glycolipid metabolism.MethodsA total of 300 pregnant women and their newborns were selected for the study between May 2022 and December 2023. Data on lifestyle and dietary habits were collected, and PAH levels in venous blood and umbilical cord blood were measured using gas chromatography-mass spectrometry. Glycolipid metabolism indicators, including fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), were also measured. Correlation and regression analyses were conducted to explore the relationships between PAH exposure and metabolic indicators.ResultsThirteen PAHs were detected in both maternal and cord blood. The median concentrations of ΣPAHs (the total concentration of the 16 detected PAHs) were 11.211 μg/L in maternal blood and 10.921 μg/L in newborns. Significant correlations were observed between PAH exposure and glycolipid metabolism, with PAH exposure linked to reduced levels of TC and TG. Factors such as proximity to roads, cooking fuel type, and dietary habits influenced PAH levels. Higher education levels were associated with lower PAH concentrations, whereas living near roads and using gas as cooking fuel increased exposure.ConclusionThere is a notable risk of PAH exposure in pregnant women and newborns in Haikou, influenced by environmental and lifestyle factors. PAH exposure during pregnancy may affect glycolipid metabolism in both mothers and newborns, highlighting the need for interventions to reduce exposure.
Machine learning techniques for predicting neurodevelopmental impairments in premature infants: a systematic review
Authors: Ortega-Leon Arantxa , Urda Daniel , Turias Ignacio J. , Lubián-López Simón P. , Benavente-Fernández Isabel 
Published: January 2025

Background and objectiveVery preterm infants are highly susceptible to Neurodevelopmental Impairments (NDIs), including cognitive, motor, and language deficits. This paper presents a systematic review of the application of Machine Learning (ML) techniques to predict NDIs in premature infants.MethodsThis review presents a comparative analysis of existing studies from January 2018 to December 2023, highlighting their strengths, limitations, and future research directions.ResultsWe identified 26 studies that fulfilled the inclusion criteria. In addition, we explore the potential of ML algorithms and discuss commonly used data sources, including clinical and neuroimaging data. Furthermore, the inclusion of omics data as a contemporary approach employed, in other diagnostic contexts is proposed.ConclusionsWe identified limitations and emphasized the significance of employing multimodal data models and explored various alternatives to address the limitations identified in the reviewed studies. The insights derived from this review guide researchers and clinicians toward improving early identification and intervention strategies for NDIs in this vulnerable population.