bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tape stripped stratum corneum samples are suitable for diagnosis and comprehensive proteomic investigation in mycosis fungoides
Authors: Qureshi Hafsa Anees , Azimi Ali , Wells Jillian , Fernandez‐Penas Pablo 
Published: February 2023

AbstractBackgroundMycosis Fungoides (MF) is a common cutaneous T‐cell lymphoma. It can sometimes be challenging to diagnose MF using current clinico‐histopathological criteria. Non‐invasive molecular profiling analysis has the potential to aid the diagnosis and understanding of MF.MethodLesional and body site matched normal stratum corneum samples were obtained from the same MF patients (n = 28) using adhesive discs, followed by proteomic analyses using data‐independent acquisition mass spectrometry (DIA‐MS). Differential abundance analyses and bioinformatic analyses were performed to identify differentially abundant proteins and altered biofunctions between the MF and normal stratum corneum samples.ResultsIn total, 1303 proteins were identified, of which 290 proteins were significantly changed in the MF cohort compared to the normal stratum corneum. Ingenuity pathway analysis (IPA) predicted the significant inhibition of cell death of cancer cells and significant activation of immune‐related activities and viral infection in the MF lesions. MF lesions were also associated with upstream regulators relating to immuno‐oncologic dysfunctions. The top‐250 variating proteins efficiently separated normal stratum corneum from matched MF samples.ConclusionNon‐invasive proteomic analysis could transform the diagnosis of MF by reducing the need for invasive biopsy. The identification of altered biological functions may serve as useful biomarkers to predict MF progression.
HLA‐DQ and ‐DR alleles in patients with SLE: A tertiary hospital‐based case–control study in Bangladesh
Authors: Khan Muhammad S. A. , Ahmed Shamim , Bandhan Iftekhar H. , Zaman Farhana , Sajib Md. Kamrul H. , Tarafder Shirin , Choudhury Minhaj R. , Haq Syed A. , Zaman Mohammad M. 
Published: February 2023

AbstractBackgroundSystemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the involvement of multiple organs and autoantibody production. This study aimed to determine the association of human leukocyte antigen (HLA)‐DQ and ‐DR alleles with SLE at a tertiary hospital in Bangladesh.MethodsThis case–control study was conducted in the Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. The patients who fulfilled the 1997 revised American College of Rheumatology classification criteria for SLE were considered cases (n = 41). The controls (n = 32) were selected from the hospital staff of BSMMU, including doctors and nurses who did not suffer from any known rheumatic diseases, and there was no such disease in their first‐degree relatives. Polymerase chain reaction using a sequence‐specific primer (PCR‐SSP) in a low‐resolution typing method was carried out on blood samples collected for HLA‐DQ and ‐DR allele typing.ResultsThe cases and controls had comparable mean ages (31 vs. 32 years), and most cases were female (95.1% vs. 34.4%). The most frequent clinical manifestations were mucocutaneous (85.4%), followed by musculoskeletal (70.7%) and constitutional symptoms (58.5%). The cases had a significantly higher frequency of HLA‐DR2 allele compared with healthy controls (70.7% vs. 43.8%; odds ratio: 3.1; 95% confidence interval: 1.2–8.2). In addition, HLA‐DQ6 allele was found to have a significant association with mucocutaneous manifestations of the cases (88.9%, P = 0.03).ConclusionsBangladeshi adults having HLA‐DR2 may be more susceptible to SLE. HLA‐DQ6 allele might be associated with mucocutaneous manifestations of SLE.
Distributed projection‐free algorithm for constrained aggregative optimization
Authors: Wang Tongyu , Yi Peng 
Published: February 2023

AbstractIn this paper, we focus on solving a distributed convex aggregative optimization problem in a network, where each agent has its own cost function which depends not only on its own decision variables but also on the aggregated function of all agents' decision variables. The decision variable is constrained within a feasible set. In order to minimize the sum of the cost functions when each agent only knows its local cost function, we propose a distributed Frank–Wolfe algorithm based on gradient tracking for the aggregative optimization problem where each node maintains two estimates, namely an estimate of the sum of agents' decision variable and an estimate of the gradient of global function. The algorithm is projection‐free, but only involves solving a linear optimization to get a search direction at each step. We show the convergence of the proposed algorithm for convex and smooth objective functions over a time‐varying network. Finally, we demonstrate the convergence and computational efficiency of the proposed algorithm via numerical simulations.
Event‐triggered adaptive stabilization control of stochastic nonlinear systems with unmodeled dynamics
Authors: Chen Yang , Liu Yan‐Jun , Liu Lei , Tong Shaocheng , Xu Tongyu 
Published: February 2023

AbstractIn this paper, we present a novel controller design method for stochastic nonlinear systems with unmodeled dynamics, uncertain parameters, and unknown covariance noise. In order to deal with these uncertainties, a new event‐based small gain controller is designed. The event‐triggered scheme can reduce the computational burden caused by disturbance and noise. By combining the technique of changing supply rate with small gain condition, a stochastic input‐to‐state practically stability Lyapunov function is obtained for the subsystem. Simultaneously, the changing supply function is used to treat with unmodeled dynamics. Based on backstepping process and adaptive control approach, the influence of unknown covariance noise is overcome. It is proved that the designed state‐feedback controller can ensure the overall system is stochastic input‐to‐state practically stability.
Clinical Description and Treatment Outcomes of Paederus Dermatitis in Phuentsholing, Bhutan in 2021: A Cross-Sectional Study
Authors: Gyeltshen Kinley , Sangye Ngawang , Tenzin Kunzang C. , Dorji Thinley 
Published: February 2023

Abstract
An increasing number of beetle population and outbreaks of irritant contact dermatitis are reported from newer geographic locations. Bhutan is one such country that witnessed an outbreak of Paederus dermatitis (PD) in Phuentsholing sub-district in 2021. This study describes the clinical symptoms, skin lesions and treatment outcomes of PD in Bhutan. This was a descriptive cross-sectional study of an outbreak of Paederus-related contact dermatitis in Phuentsholing, Bhutan. Clinical symptoms, skin lesions, duration of illness, recovery time and response to treatment were recorded. Of the 81 patients with PD, the males constituted 54% (44) and the mean age was 22 years (range: 1–51 years). The commonly affected groups were those aged 11–20 years (40.7%) and school or college students (50.6%). The common symptoms were pain, itching, redness, tenderness and blister formation. The lesions were erythematovesicular (70%), linear (54.3%) and kissing lesions (28.4%). All patients received some form of topical or oral steroid therapy and recovery was 100%. The mean duration from the onset till the recovery of the skin rash was 13 days (SD ± 8.3 days). PD outbreak is a self-limiting form of contact dermatitis. This is the first report of PD in the sub-Himalayan region and may be linked to climate change. There is a need for active surveillance and monitoring of such emerging weather/climate-related agents for appropriate health system response in disease prevention and treatment.
Passionate and psychologically‐undetached: A moderated‐mediated investigation of psychological distress among engaged employees
Authors: Lajom Jennifer Ann L. , Teo Stephen , de Carvalho Filho Moises Kirk , Stanway Alicia 
Published: February 2023

AbstractGuided by the effort‐recovery model and the dualistic model of passion, we tested a conditional process model that examined the relationships between work engagement, workplace passion, psychological detachment, and psychological distress among Japanese professionals. We conducted an online panel survey across two time points, six weeks apart (N = 202 matched responses) where we measured all the variables at both instances. Findings show that engaged employees become susceptible to psychological distress due to decreased levels of psychological detachment. The moderating role of work passion was partially supported: being obsessively passionate towards work exacerbates this relationship further while contrary to expectations, the moderating role of harmonious passion was not significant. Findings suggest the possibility that engaged employees are less likely to switch off, which predisposes them to ill‐being at work, and this becomes apparent among employees with less volitional opportunities in the workplace.
An expanded Smithian–Spathian (Lower Triassic) boundary from a reefal build‐up record in Oman: implications for conodont taxonomy, high‐resolution biochronology and the carbon isotope record
Authors: Leu Marc , Bucher Hugo , Baud Aymon , Vennemann Torsten , Luz Zoneibe , Hautmann Michael , Goudemand Nicolas 
Published: February 2023

AbstractSome 2.7 myr after the Permian–Triassic boundary mass extinction, a stepwise extinction of the nekton (ammonoids and conodonts) ended at the Smithian–Spathian boundary (SSB) during an episode of climate cooling. SSB records from continental shelves are usually affected by an unconformity, suggesting a forced regression of glacio‐eustatic origin. Here, we document a new 30‐m‐thick SSB section from Jebel Aweri (Batain Plain, Oman) that provides an exceptionally complete and expanded record preserved in an exotic block. Most of this SSB section consists of microbial boundstone build‐ups with a framework of metazoan bioclasts that formed in shallow water on an offshore seamount. In Wadi Musjah (Hawasina nappes, Oman), another exotic block records the SSB in a deeper water setting represented by Hallstatt‐type facies. These two sections provide a unique perspective on the early Spathian rapid re‐diversification of conodonts. They led to a thorough revision of conodont taxonomy around the SSB and to the construction of the highest resolution biochronological scheme for this time interval in the Tethys. A total of five SSB sections from Oman representing both offshore seamounts and lower slope deposits were included in a high‐resolution, quantitative unitary associations (UA) analysis. The resulting 8 conodont biozones are intercalibrated with ammonoid zones and with the carbonate carbon isotope record ultimately placing the SSB in the interval of separation between UAZ3and UAZ4. Only the association ofNovispathodus pingdingshanensiswithIcriospathodus crassatuscan be used to unambiguously characterize the base of the Spathian.
System lacks systems thinking: Top‐down organization and actor agency in China's agricultural extension system
Authors: Liao Chengdong , Ross Helen , Jones Natalie , Palaniappan Gomathy 
Published: February 2023

AbstractExtension of agricultural technology is important for farmers to improve their practices. However, criticisms are made of top‐down extension systems, which fail to meet smallholder farmers' needs due to reliance on a linear, one‐way transfer approach. Meanwhile, the role of farmers' knowledge is gaining attention in the academic literature on agricultural extension, but yet overlooked in the applied Chinese context. These issues require a holistic analysis, towards, which systems principles can provide insights. We present a case study of the interaction between the national extension system and smallholder farmers in Guangxi, China. We found that the system constrains the autonomy and capacity of extension officers in implementing activities. Also, farmers actively exercise agency in identifying and responding to farming issues. We argue that the system should build the adaptive capacity of officers and farmers by fostering systems thinking to enable smallholder farmers to tackle farming complexity in a changing world.
Indirect weather‐based approaches for increasing power transfer capabilities of electrical transmission networks
Authors: Keyvani Behzad , Whelan Eoin , Doddy Eadaoin , Flynn Damian 
Published: February 2023

AbstractDynamic line rating (DLR) systems are recognized as a cost‐effective and socially accepted asset for relieving network congestion and uprating existing transmission systems, based upon accessing additional weather‐dependent capacity of overhead lines. Although direct and indirect DLR methods are available, utilization of indirect weather‐based approaches, that is, sensors are not installed on the conductor, are of increasing interest due to fast installation times, that is, no requirement for line outages and lower capital costs, with achievable potential for wide‐area implementation. An extensive review is presented on the components and requirements of such systems, including weather stations, forecasting models, downscaling and DLR calculations, overhead line and conductor thermal models, and communication platforms. In addition, the features of practical instances of these systems are briefly reviewed. Moreover, a systematic approach is introduced for statistical evaluation of the high‐level DLR potential across an entire region, as well as an assessment of the line‐level DLR ampacities within an electrical grid, based on (weather forecasting) reanalysis data. The proposed methodology can disclose available additional capacity as part of early‐stage planning for wide‐area DLR systems. The island of Ireland and the 110 kV network of the Republic of Ireland (ROI) power system are considered as the study cases, with comparison made against seasonal static ratings and ambient temperature adjusted line rating methods.This article is categorized under:
Energy and Power Systems > Energy Infrastructure
Climate and Environment > Net Zero Planning and Decarbonization
An All-Optical Physiology Pipeline Toward Highly Specific and Artifact-Free Circuit Mapping
Authors: Backhaus Hendrik , Ruffini Nicolas , Wierczeiko Anna , Stroh Albrecht 
Published: February 2023

AbstractAll-optical physiology of neuronal microcircuits requires the integration of optogenetic perturbation and optical imaging, efficient opsin and indicator co-expression, and tailored illumination schemes. It furthermore demands concepts for system integration and a dedicated analysis pipeline for calcium transients in an event-related manner. Here, firstly, we put forward a framework for the specific requirements for technical system integration particularly focusing on temporal precision. Secondly, we devise a step-by-step guide for the image analysis in the context of an all-optical physiology experiment. Starting with the raw image, we present concepts for artifact avoidance, the extraction of fluorescence intensity traces on single-neuron basis, the identification and binarization of putatively action-potential-related calcium transients, and finally ensemble activity analysis.
Miniature Multiphoton Microscopes for Recording Neural Activity in Freely Moving Animals
Authors: Ozbay Baris N. , Futia Gregory L. , Ma Ming , McCullough Connor , Young Michael D. , Restrepo Diego , Gibson Emily A. 
Published: February 2023

AbstractMiniaturized head-mounted microscopes for in vivo recording of neural activity have gained much recognition within the past decade of neuroscience research. In combination with fluorescent reporters, these miniature microscopes allow researchers to record the neural activity that underlies behavior, cognition, and perception in freely moving animals. Single-photon miniature microscopes are convenient for widefield recording but lack the increased penetration depth and optical sectioning capabilities of multiphoton imaging. Here we discuss the current state of head-mounted multiphoton miniature microscopes and introduce a miniature head-mounted two-photon fiber-coupled microscope (2P-FCM) for neuronal imaging with active axial focusing enabled using a miniature electrowetting lens. The 2P-FCM enables three-dimensional two-photon optical recording of structure and activity at multiple focal planes in a freely moving mouse. Detailed methods are provided in this chapter on the 2P-FCM design, operation, and software for data analysis.
An Epiperimetric Inequality Approach to the Regularity of the One-Phase Free Boundaries
Authors: Velichkov Bozhidar 
Published: February 2023

AbstractThroughout this section, we will use the notation
$$\displaystyle W_0(u)=\int _{B_1}|\nabla u|{ }^2\,dx-\int _{\partial B_1}u^2\,d\mathcal {H}^{d-1}\qquad \text{and}\qquad W(u)=W_0(u)+|\{u>0\}\cap B_1|, $$

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where B1 is the unit ball in
$$\mathbb {R}^d$$

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, d ≥ 2 and u ∈ H1(B1).
Regularity of the Flat Free Boundaries
Authors: Velichkov Bozhidar 
Published: February 2023

AbstractThis chapter is dedicated to the regularity of the flat free boundaries. In particular, we will show how the improvement of flatness (proved in previous section) implies the C1, α regularity of the free boundary (see Fig. 8.1). The results of this section are based on classical arguments and are well-known to the specialists in the field. The main result of the chapter is the following.
Long-term (≥ 15 years) outcome quality after Class II:1 bionator or Herbst multibracket appliance treatment
Authors: Bock Niko Christian , Jungbauer Rebecca , Rudzki Ingrid , Proff Peter , Ruf Sabine 
Published: February 2023

Abstract
Purpose
To compare the long-term outcome quality (≥ 15 years) of Class II:1 treatment using either a bionator (BIO) or a Herbst–multibracket appliance (HMB).

Methods
Patients who underwent functional treatment during the ideal treatment period for the respective approach (prepuberty vs. peak/postpeak) were assessed. Inclusion criteria were overjet ≥ 4 mm, skeletal Class II and availability of study casts from before, after and ≥ 15 years after treatment. The study casts were assessed using the Peer Assessment Rating (PAR) index and standard orthodontic cast measurements.

Results
During treatment, PAR score, overjet and sagittal occlusal relationship improved significantly in all groups. Long-term, there was a significant increase of incisor irregularity in the upper (HMB) and lower (BIO) arch and a significant decrease of lower arch width 3 – 3 (BIO). PAR score, overjet, and sagittal occlusal relationship remained stable long-term. Intergroup comparisons revealed significant differences between the BIO and HMB groups in terms of lower arch width (6 – 6), upper and lower arch width (3 + 3/3 – 3) as well as sagittal molar relationship.

Conclusions
The achieved improvement in PAR score, overjet, and sagittal occlusion remained comparably stable long-term in all groups. The long-term changes are probably a consequence of natural aging.
Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study
Authors: de Klerk Juliette A. , Beulens Joline W. J. , Mei Hailiang , Bijkerk Roel , van Zonneveld Anton Jan , Koivula Robert W. , Elders Petra J. M. , ’t Hart Leen M. , Slieker Roderick C. 
Published: February 2023

Abstract
Aims/hypothesis
The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes (MD) and mild diabetes with high HDL-cholesterol (MDH). This was to increase our understanding of different molecular mechanisms underlying the five putative clusters of type 2 diabetes.

Methods
Participants in the Hoorn Diabetes Care System (DCS) cohort were clustered based on age, BMI, HbA1c, C-peptide and HDL-cholesterol. Whole blood RNA-seq was used to identify differentially expressed lncRNAs and mRNAs in a cluster compared with all others. Differentially expressed genes were validated in the Innovative Medicines Initiative DIabetes REsearCh on patient straTification (IMI DIRECT) study. Expression quantitative trait loci (eQTLs) for differentially expressed RNAs were obtained from a publicly available dataset. To estimate the causal effects of RNAs on traits, a two-sample Mendelian randomisation analysis was performed using public genome-wide association study (GWAS) data.

Results
Eleven lncRNAs and 175 mRNAs were differentially expressed in the MOD cluster, the lncRNA AL354696.2 was upregulated in the SIDD cluster and GPR15 mRNA was downregulated in the MDH cluster. mRNAs and lncRNAs that were differentially expressed in the MOD cluster were correlated among each other. Six lncRNAs and 120 mRNAs validated in the IMI DIRECT study. Using two-sample Mendelian randomisation, we found 52 mRNAs to have a causal effect on anthropometric traits (n=23) and lipid metabolism traits (n=10). GPR146 showed a causal effect on plasma HDL-cholesterol levels (p = 2×10–15), without evidence for reverse causality.

Conclusions/interpretation
Multiple lncRNAs and mRNAs were found to be differentially expressed among clusters and particularly in the MOD cluster. mRNAs in the MOD cluster showed a possible causal effect on anthropometric traits, lipid metabolism traits and blood cell fractions. Together, our results show that individuals in the MOD cluster show aberrant RNA expression of genes that have a suggested causal role on multiple diabetes-relevant traits.

Graphical abstract
General Anesthesia Versus Regional Anesthesia in the Elderly Patients Undergoing Hip Fracture Surgeries: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials
Authors: Cao Mu‐Min , Zhang Yuan‐Wei , Sheng Ren‐Wang , Gao Wang , Kang Qian‐Rui , Gao Yu‐Cheng , Qiu Xiao‐Dong , Rui Yun‐Feng 
Published: February 2023

AbstractBackgroundSurgery is the preferred treatment option for the elderly patients with hip fractures. However, the choice of general anesthesia (GA) or regional anesthesia (RA) remains controversial. The quality of evidence has further improved with the advent of several high‐quality randomized clinical trials (RCTs) in the last two years. The purpose of this study was to compare the clinical outcomes of two anesthetic techniques in elderly patients undergoing hip fracture surgeries.MethodsEligible studies were identified from PubMed/MEDLINE, Web of Science, Scopus, EMBASE and reference lists from January 2000 to June 2022 in this current systematic review and meta‐analysis. The outcomes included the surgery‐related outcomes (duration of surgery, duration of anesthesia, intraoperative blood loss and number of transfusions) and postoperative outcomes (30‐day mortality, postoperative delirium,cardiovascular events and other complications).ResultsA total of 10 RCTs were included, and a total of 3594 patients were analyzed. RA was associated with shorter duration of surgery, shorter length of hospital stays and less intraoperative blood loss compared to GA. There were no significant differences between the two groups in the number of blood transfusions, duration of anesthesia, 30‐day mortality or postoperative delirium.ConclusionsOur pooled analysis identified no significant differences in terms of the safety between RA and GA, while RA reduces intraoperative blood loss, length of hospital stays and duration of surgery. These results suggest that RA appears to be preferable for the elderly patients with hip fractures.