bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing a novel C50N10 azafullerene with chained nitrogen atoms on a buckyball pole; structure, stability, vibration and electronic properties
Authors: Nekoei A-Reza , Haghgoo Sanaz , Hamzekhani Zahra Hamzavi 
Published: January 2023

Abstract
For C50N10 molecule, four structural isomers including 3 structures with chain nitrogen atoms on a fullerene buckyball pole (NP-isomers) and one isomer with separated nitrogen atoms (SN-isomer) have been studied using the density functional theory method. All isomers have been studied with and without symmetric constraints, and the symmetry influence on the structure and stability of each isomer has been investigated. Although the studied NP structures have lower stability than the SN-isomer, but some reasons (such as their more all-carbon hexagonal rings, breaking some of their N − N bonds for relative opening of the cage and creating bigger rings in order to getting rid from the unfavorable strain, as well as decreasing the N − N lone-pair repulsions) lead to the reasonable stability of these structures with the bonded nitrogen atoms. The results of atomization energy and vibrational frequency calculations indicate that isomers with the bonded nitrogen atoms have acceptable thermodynamic stabilities and do not decompose into their constituent components. Investigation on the structural parameters demonstrates important roles of the number of all-carbon hexagonal rings, the number of N-N junction, and the molecule symmetry in the stability of the structures with the bonded nitrogen atoms. Study on the electronic and optical properties indicate that the target structures exhibit interesting properties to be proper candidates for donor-acceptor pairs, fabrication of optical instruments, and application in molecular electronics.
Could parental awareness of DBR influence youth off-campus sports? Test of a conditional process model
Authors: Lou Hu , Tan Shuying , Liu Ping 
Published: January 2023

Abstract
DBR provides a new opportunity to increase youth sports.
Methods: Through a nationwide sampling survey, this study demonstrated the relationship between parents' awareness of DBR, parents' educational anxiety, parents' attitudes towards youth off-campus sports, and constructed a conditional process model.
Result: parent’s awareness of DBR significant positively impact youth sports (β = 0.103, P <0.01), but significant negatively impact parent’s education anxiety (β = - 0.305, P < 0.01) which played a significant intermediary role between parent’s awareness of DBR and youth off-campus sports (β = 0.031, 95%CI: 0.020 ~ 0.044). The dimensions of parent’s education anxiety only academic performance anxiety (β = 0.034, 95%CI: 0.021~0.047), parent-child interaction anxiety (β = 0.027, 95% CI: 0.014 ~ 0.038) and learning attitude anxiety (β = 0.024, 95%CI: 0.015 ~ 0.033) presenting significant mediating effects. The interaction between parent’s education anxiety and parent’s attitudes toward youth sports had a significant positive impact on youth off-campus sports (β = 0.008, P < 0.01).
Conclusion: parent’s awareness of DBR positively impact youth off-campus sports. Three dimensions of parent’s educational anxiety mediate in the process model. Parent’s attitudes toward youth sports can magnify the relationship between parent’s education anxiety and youth off-campus sports.
Unraveling epigenetic mechanisms causing cognitive dysfunction in experimental diabetes
Authors: Aggarwal Aanchal , Yadav Binduma , Sharma Nishtha , Kaur Raminder , Rishi Vikas 
Published: January 2023

Abstract
Epigenetic mechanisms related to diabetes-afflicted CNS complications are largely unknown. The present study investigated the role of epigenetic mechanisms causing cognitive dysfunction in the Type 1 and 2 diabetic encephalopathy mice model. Dynamic changes in diabetic parameters like fasting blood glucose levels, glucose tolerance tests, and insulin levels were observed after the induction of diabetes. Cognitive functions were significantly diminished in T1D and T2D mice examined by the Morris water maze, novel object recognition test, and Y Maze. Histone profiling revealed a significant reduction in H3 and H4 acetylation in the cortex and hippocampus of T1D and T2D mice vs Controls. While histone deacetylase (HDAC) activity was significantly elevated in brain regions of T1D and T2D mice, the histone acetyltransferase (HAT) activity remained unchanged. Significantly increased HDAC 2, HDAC 3, and HDAC 4 protein and mRNA expression observed in T1D and T2D brain regions may corroborate for increased HDAC activity. No significant change was observed in protein and mRNA expression of HDAC 1, 5, 6, and 7 in diabetic brains. Reduced H3 and H4 acetylation paralleled transcriptional repression of memory-related markers BDNF, SYP, and Psd-95 in the cortex and hippocampus of T1D and T2D. Pharmacological inhibition of HDAC activity by Trichostatin A restored the cognitive changes observed in T1D and T2D. The present study provides a better insight into molecular mechanisms related to diabetes-dependent memory changes that can help to generate new advances for therapeutics to be developed in this area.
Engaging the Community Served: a U.S. Cancer Center’s Facebook Live Cancer Awareness Campaign for Spanish-speaking Latinos during COVID-19
Authors: Mora Javier , Romo Raul , Dempsey Sandra , Silva Betzaida , Nevels Debra , Leone Gustavo , Stolley Melinda 
Published: January 2023

Abstract
Cancer is the leading cause of mortality in U.S. Latino adults, a group with limited access to screening, higher rates of advanced disease, and prone to online misinformation. Our project created a Facebook Live social media video campaign on general cancer prevention, screening, risk, information, and resources, targeting Spanish-monolingual Latinos during the COVID-19 pandemic. Content was delivered in Spanish by fluent, ethnically concordant topic experts and cancer center staff. Four prerecorded and three livestream interview videos were produced, amassing over 161 shares, 1000 engagements, 12,000 views, 19,000 people reached, and 34,000 impressions in a span of four months. Strengths of this project included developing community partnerships and collaborations, providing evidence-based cancer information in a culturally responsive manner to often-excluded community members during COVID-19 pandemic, and presenting our cancer center as an accessible resource to the wider community. Future directions include formalizing evaluation strategies to capture medical engagement via cancer screening and detection rates, delivering focused cancer discussions by disease sites, and further expanding audience base through mixed media formats.
Virulence, Antimicrobial Risistance and Molecular Characteristics of Carbapenem-risistant Klebsiella pneumoniae in a Hospital in Shijiazhuang City from China
Authors: Guo Yumei , Liu faqiang , Zhang Yulan , Wang Xiaoli , Gao Weili , Xu Baohong , Li Yuxue , song ning 
Published: January 2023

Abstract
Carbapenem-resistant Klebsiella pneumoniae (CRKP), as one of the most common drug-resistant bacteria threatening human health, is hyper-resistant to multiple antimicrobial drugs and carbapenems, which can by dealt with only limited clinical treatment options. This study described the epidemiological characteristics of CRKP in this tertiary care hospital from 2016 to 2020. Specimen sources included blood, sputum, alveolar lavage fluid, puncture fluid, secretions from a burn wound, and urine. Among the 87 carbapenem-resistant strains, ST11 was the predominant isolate, followed by ST15, ST273, ST340, and ST626. These STs were in broad agreement with the STs defined by PFGE clustering analysis in discriminating clusters of related strains. Most CRKP isolates contained the blaKPC-2 gene, some isolates carried the blaOXA-1, blaNDM-1 and blaNDM-5 genes, and the isolates carrying carbapenem resistance genes were more resistant to the antimicrobials of β-lactams, carbapenems, macrolides and fluoroquinolone. The OmpK35 and OmpK37 genes were detected in all CRKP strains, and the Ompk36 gene was detected in some CRKP strains. All detected OmpK37 had 4 mutant sites, OmpK36 had 11 mutant sites, while no mutant sites were found in OmpK35. More than half of the CRKP strains contained the OqxA and OqxB efflux pump genes. The virulence genes were most commonly combined with urea-wabG-fimH-entB-ybtS-uge-ycf. Only one CRKP isolate was detected with the K54 podoconjugate serotype. This study elucidated the clinical epidemiological features and molecular typing of CRKP, and grasped the distribution of drug-resistant genotypes, podocyte serotypes and virulence genes of CRKP, providing some guidance for the subsequent treatment of CRKP infection.
Isolation, Microscopic and Magnetotactic Characterization of Magnetospirillum Moscoviense Ms-24 From Banjosa Lake, Pakistan
Authors: Salam Maria Abdul , Korkmaz Nuriye , Cycil Leena Mavis , Hasan Fariha 
Published: January 2023

Abstract
At currently, approximately 70 species of magnetotactic bacteria have been identified; thus, there is an urgent need to identify more magnetotactic bacteria from diverse sources with potential applications in industry and biotechnology. To the best of our knowledge, this is the first magnetotactic bacterial strain discovered in Pakistan. The first magnetotactic bacteria, Magnetospirillum moscoviense MS-24, was isolated from Banjosa Lake (Rawalakot), Pakistan, in the current investigation. Magnetospirillum moscoviense MS-24 was screened using the Racetrack method and its temperature and pH were optimized. The Magnetospirillum moscoviense MS-24 were physically characterised using Atomic Force Microscopy, High-Resolution Scanning Electron Microscopy, and Transmission Electron Microscopy. The current study used microscopy to illustrate the shape of bacteria and to find a very obvious chain of magnetosomes within the bacterial cell. The Magnetospirillum moscoviense MS-24 measured about 4 0.04m in length and 600 0.02nm in diameter. The micro fluidic chip experiments were also used to detect magnetotaxis behaviour in bacteria.
Evaluating Brazil’s national administrative claims data for real-world pharmacoepidemiologic studies: Trends in rheumatoid arthritis using DATASUS (2010–2020)
Authors: Birck Marina Gabriela , Ferreira Rafaela , Curi Marco , Krueger Whitney S , Julian Guilherme Silva , Liede Alexander 
Published: January 2023

Abstract
Objective
Our study assessed DATASUS as a potential source for pharmacoepidemiologic studies in rheumatoid arthritis (RA) in the Brazilian population focusing on treatment patterns and determinants of initiating or switching to a novel therapy.
Methods
Descriptive database study of RA patients with at least one claim of RA and ≥ 2 claims of disease-modifying anti-rheumatic drug (DMARD); conventional synthetic (cs), biologic (b) or targeted synthetic (ts) DMARD with more than < 6 month of follow-up from 01-Jan-to 31-Dec-2020. Analyses were stratified for SUS and non-SUS-exclusive user cohorts.
Results
We identified 250,251 patients with RA: mean age of 58.4 years, majority female (83%) and white (58%). 62% were SUS-exclusive and 38% non-SUS exclusive. Most common bDMARD was adalimumab and etanercept. Age (adjusted odds ratio 1.78 [50+]; 95% CI 1.57–2.01), SUS exclusive (0.53;0.47–0.59), distance to clinic [160 + km] (0.57;0.45–0.72), and pre-index csDMARD claims (1.23;1.08–1.41) were independent predictors of initiating a novel oral tsDMARD. Switching from bDMARD to tsDMARD, associations were similar, except directionality of SUS exclusive (adjusted hazard ratio 1.10;1.03–1.18), distance to clinic (1.18;1.03–1.35), and number of previous bDMARD (0.15;0.14–0.16).
Conclusion
DATASUS is a valid source for treatment-related analyses in RA reflecting the public health system in Brazil.
An evaluation of the influence of the images of orthodontists with malocclusions on social media and their impact on professional credibility
Authors: Bark Mohamad , Gasparello Gil , Hartmann Giovani , Mota-Júnior Sergio , Acciaris Fabio , Pithon Matheus , Tanaka Orlando 
Published: January 2023

Abstract
Objectives This study aimed to evaluate perceptions of the credibility of orthodontists with malocclusions and whether these affect the willingness of laypeople to become patients through eye-tracking technology and a questionnaire.
Materials and methods Ninety-five lay raters are evaluated through eye tracking and a questionnaire comprising 12 images of orthodontists with malocclusions. The malocclusions selected through the Orthodontic Treatment Need Index (IOTN) groups are: IOTN grade 1 (close to the ideal), 3 (anterior crowding), and 5 (with diastemas). Eye-tracking data are collected for the fixation points, and credibility was analyzed through questionnaires. A word cloud was generated on the Mentimeter platform. To validate the study and conduct a reliability test, the questionnaire was conducted twice during the preliminary stage of data collection.
Results IOTN 1 received a better evaluation for credibility and competence and shows a significant difference when compared to IOTN 3 (p < 0.001) and 5 (p < 0.001). In addition, raters felt more confident in installing an orthodontic treatment appliance, if necessary, with an IOTN 1 orthodontist compared to IOTNs 3 and 5. For the fixation points, a difference was seen, since the attention of the individuals for IOTN 1 was divided between the eyes and the mouth, while for IOTN 3 and 5, the raters paid more attention to the mouth. The word cloud showed that the raters for IOTN 3 and 5 repeat the words “crooked teeth” and “spacing” most often.
Conclusion Orthodontists with IOTN 1 were perceived as more competent, reliable, and professional, and laypeople are more likely to become their patients.
Clinical significance The professionals' smiles play a large role in laypeople's decision to select them as their orthodontist, and strategic use of social media, can bring health information to many more people more rapidly and directly.
Opioid-sparing anesthesia with dexmedetomidine provides stable hemodynamic and short hospital stay in non-intubated video-assisted thoracoscopic surgery: a propensity score matching cohort study
Authors: Ke Hui-Hsuan , Liou Jing-Yang , Teng Wei-Nung , Hsu Po-Kuei , Tsou Mei-Yung , Chang Wen-Kuei , Ting Chien-Kun 
Published: January 2023

Abstract
Objectives
Dexmedetomidine is an alpha-2 agonist with anti-anxiety, sedative, and analgesic effects and causes a lesser degree of respiratory depression. We hypothesized that the use of dexmedetomidine in non-intubated video-assisted thoracic surgery (VATS) may reduce opioid-related complications such as postoperative nausea and vomiting (PONV), dyspnea, constipation, dizziness, skin itching, and cause minimal respiratory depression, and stable hemodynamic status.
Methods
Patients who underwent non-intubated VATS lung wedge resection with propofol combined with dexmedetomidine (group D) or alfentanil (group O) between December 2016 and May 2022 were enrolled in this retrospective propensity score matching cohort study. Intraoperative vital signs, arterial blood gas data, perioperative results and treatment outcomes were analyzed.
Results
Of 100 patients included in the study (group D, 50 and group O, 50 patients), group D had a significantly lower degree of decrement in the heart rate and the blood pressure than group O. Intraoperative one-lung arterial blood gas revealed lower pH and significant CO2 retention in group O than group D. The common opioid-related side effects, including PONV, dyspnea, constipation, dizziness, and skin itching, all of which occurred more frequently in group O than in group D. Patients in group O had significantly longer postoperative hospital stay and total hospital stay than group D, which might be due to opioid-related side effects postoperatively.
Conclusions
The application of dexmedetomidine in non-intubated VATS resulted in a significant reduction in perioperative opioid-related complications and maintenance with acceptable hemodynamic performance. These clinical outcomes may enhance patient satisfaction and shorten the hospital stay.
Non-transferable Blockchain-based Identity Authentication
Authors: Fu Yuxia , Shao Jun , Huang Qingjia , Zhou Qihang , Feng Huamin , Jia Xiaoqi , Wang Ruiyi , Feng Wenzhi 
Published: January 2023

Abstract
Due to the identification functionality, identity authentication is the first and primary security step in many information systems. There exist many works dedicated to giving secure identity authentication. However, most of the existing schemes suffer from at least one of the following problems: heavy account management, single point of failure, and privacy leakage. To tackle these challenges, we propose two blockchain-based identity authentication schemes in this paper. One is based on the famous Diffie-Hellman key exchange protocol and is efficient but with user-verifier interaction. The other utilizes the ring signature, which is non-interactive with a small computational cost. Besides the traditional security properties, such as unforgeability and identity anonymity, our proposed schemes can hold non-transferability, i.e., the verifier cannot prove the user's identity authentication to any third party. At last, the extensive experimental results demonstrate that our proposals are practical and efficient.
Mechanisms of Nrf2 and NF-κB pathways in diabetic wound and potential treatment strategies
Authors: Cai Feiyu , Chen Wenjiao , Zhao Ruomei , Liu Yi 
Published: January 2023

Abstract
The issue of delayed wound healing or nonhealing in diabetic patients presents a challenge for modern medicine. A number of attempts have been made to understand the mechanisms behind diabetic wound. In a hyperglycemic environment, increased intracellular reactive oxygen species (ROS) disturb the balance between oxidation and antioxidant, causing the wound environment to deteriorate. It has been established that the nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB) pathways play an important role in regulating inflammation and oxidative stress. Several potential treatment strategies involving Nrf2 and/or NF-κB pathways have been explored in previous studies. Hence, we analyzed mechanisms and changes in Nrf2 and NF-κB pathways in response to oxidative stress and inflammation in diabetic environment. Additionally, we reviewed potential treatment strategies from the past five years for diabetic wound by Nrf2 and/or NF-κB pathways, including receptor agonists, vitamins, hormones, exosomes, drugs, plants, and biomaterials. It may be useful to develop drugs to promote diabetic wound healing.
Political Ideology of Disaster Reduction: Does Innovation Matter?
Authors: Avom Desire , Ndjokou Itchoko Motande Mondjeli Mwa , atanga Donald Ferdinand Okere 
Published: January 2023

Abstract
The aim of this article is to study the effect of government ideology on natural disaster prevention in developing countries, taking into account the role of innovation. The study covers a sample of 91 developing countries over the period 1990 to 2020. The methodology used refers to binary choice models, since our dependent variable takes the value 1 if the country has experienced a natural disaster at a given date and 0 otherwise. We implement here a fixed effects logit model. Our results show that for all three declinations of government ideology (Right, Left and Centre) innovation tends to increase the probability of natural disasters in developing countries. This result is consistent with the alternative measure of innovation (total factor productivity) only for left-wing governments. We can suggest that the focus should be on policies to increase building standards and encourage sound innovation.
Jel Codes : P26, Q54, Q55.
Clinical Plasma Cells-related Genes to Aid Therapy in Colon Cancer
Authors: Zhang Qi , Feng Xiao , Zhang Mingming , Sun Wenjing , Zhai Yuqing , Qing Shuangshuang , Liu Ying , Zhao Haoran , Zhang Yi , Ma Zhaoqun , Sun Jing 
Published: January 2023

Abstract
Tumor immune microenvironment (TIME) of colon cancer (CC) shows quite a lot immune cell infiltration (IMI), and have been identified to be extensively drawn into the evolution of CC. Accumulated evidence demonstrated that plasma cells (PC) play an extremely significance role in advance of antitumor immune. Nonetheless, comprehensive analysis of PC infiltration in clinical prognosis and immunotherapy was poor in CC. This reasearch systematically addresses the gene expression model and clinical information of colon cancer patients (CCP) downloaded from the TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) databases in the current study. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), GSVA, and the MAlignant Tumors using Expression data (ESTIMATE) algorithm were employed to research the potential mechanism and pathways. Immunophenoscore (IPS) was executed to evaluate immunotherapeutic significance of risk score (RS). Half maximal inhibitory concentration (IC50) of chemotherapeutic medicine was predicted by employing the pRRophetic algorithm. Herein, 513 CC samples (including 472 tumor samples and 41 normal samples) were collected from TCGA-GDC database. Significant black module and 313 candidate genes were considered as PC-related genes by accessing WGCNA. Five pivotal genes were established through multiple analysis, which perform excellent prognostic. Then, we futher to explored underlying correlation between RS with tumor mutation burden (TMB). In addition, RS obviously correlated with various of tumor immune microenvironment (TIME). Different risk CC samples showed various signaling pathways activity and pivotal different sensitivities to administering chemotherapy. At the end, the biological roles of CD177 gene were uncovered in CC.
Physical Activity intervention using Badminton sports - A study protocol for Cardiovascular and Neuromuscular function among older adults in UAE
Authors: Hazari Animesh , Kumar Praveen 
Published: January 2023

Abstract
Background
The World Health Organization has declared physical inactivity as fourth leading cause of death and major risk factor non-communicable diseases. Studies suggest that the higher prevalence for non-communicable disease adds to extreme health and financial burden to United Arab Emirates and promotion of physical activities could help combat this situation. Sports play a significant role in the promotion of physical activity. Badminton holds a significant position in popularity for outdoor sports. Among all sports, badminton targets the cardiovascular, musculoskeletal, and neurological systems significantly
Methodology:
An Experimental, double blinded randomized controlled trial would be conducted at the Body and Soul Sport Complex, Gulf Medical University, UAE. A total of 120 older adults (40 to 70 years) would be divided into three groups of 40 each viz. with non- communicable disease (WCN), without non- communicable disease (WICN) and healthy control group (HCG). Physical activity intervention consists of two months (8 weeks), 3 days a week Badminton session to WCN and WICN group for major cardiovascular and neuromuscular parameters. A comparison would be done between and within group at baseline and post 2 months badminton sessions with the age and gender matched HCG.
Discussion
The study is aimed to determine the effects of physical activity on cardiovascular and neuromuscular functions of older adults in UAE along, thereby reducing the burden on non-communicable diseases with engagement into sports activities. The immediate impact can be seen at drawing attention of the authorities and changes in the status of non-communicable disease among UAE population with introduction of such physical activity program on larger scale. The impact could also be seen with the development of necessary infrastructure and instrumentation in other parts of the country. The findings would encourage people to engage themselves in outdoor sports activities and incorporate this in daily routine for better body functioning.
Trial Registration:
The study has been registered under the Clinical Trial Registry (REF/2022/02/051455), February 8th ,2022, http://ctri.nic.in