bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immungenetik beeinflusst Infektion und Verlauf von COVID-19
Authors: Lehmann Claudia , Doxiadis Ilias 
Published: September 2023

AbstractIn the present report, we concentrate on the influence of immunogenetics on the SARS-CoV-2 infection. A total of 527 SARS-CoV-2 PCR positive and negative individuals from Saxony was investigated. We used NGS for HLA-A, B, C, DRB1, DRB345, DQA1, DQB1, DPA1, and DPB1 typing. Then, we defined 26 genes and 5 platelet genes. Here we discuss possible predisposition of individuals expressing specific HLA alleles or combinations.
Does familiarity with the attraction matter? Antecedents of satisfaction with virtual reality for heritage tourism
Authors: Nam Kichan , Baker Jeff , Dutt Christopher S. 
Published: September 2023

AbstractVirtual reality (VR) is a topic of growing interest. While many researchers have identified factors that influence satisfaction with VR, additional important factors remain uninvestigated. In our research model, system quality, presence, and authenticity influence two mediating variables of enjoyment and usefulness of information. Enjoyment (a hedonic aspect of the VR experience) and usefulness of information (a utilitarian aspect), in turn, influence satisfaction, with familiarity moderating both of these relationships. PLS analysis of survey data collected in a heritage tourism context finds relationships that have not been previously identified. While system quality and authenticity are associated with enjoyment and usefulness of information, presence is positively associated only with enjoyment. Familiarity negatively moderates the relationship between enjoyment and satisfaction with VR. This study thus extends prior research on a key metaverse technology, VR, by identifying and explicating the roles of authenticity and familiarity—and also extends prior research by focusing on the hedonic and utilitarian dimensions of the VR experience.
Inference on optimal treatment assignments
Authors: Armstrong Timothy B. , Shen Shu 
Published: September 2023

AbstractWe consider inference on optimal treatment assignments. Our methods allow inference on the treatment assignment rule that would be optimal given knowledge of the population treatment effect in a general setting. The procedure uses multiple hypothesis testing methods to determine a subset of the population for which assignment to treatment can be determined to be optimal after conditioning on all available information, with a prespecified level of confidence. A Monte Carlo study confirms that the inference procedure has good small sample behavior. We apply the method to study Project STAR and the optimal assignment of a small class intervention based on school and teacher characteristics.
Comorbid Depressive and Anxiety Symptomatology in Older Adults: The Role of Aging Self-Stereotypes, Loneliness, and Feelings of Guilt Associated with Self-Perception as a Burden
Authors: Pedroso-Chaparro María del Sequeros , Cabrera Isabel , Márquez-González María , Ribeiro Óscar , Losada-Baltar Andrés 
Published: September 2023

Abstract
The main objective of this study was to analyze the differences between older adults’ symptom profiles (subclinical, anxiety, depressive, and comorbid) in negative aging self-stereotypes, loneliness, and feelings of guilt associated with self-perception as a burden. Participants were 310 community-dwelling people aged 60 years and over. The sample was grouped into four symptom profiles of older adults: anxiety, depressive, comorbid anxiety-depression, and subclinical symptoms. We carried out multinomial logistic regression analyses to analyze the role of assessed variables in the explanation of the four symptom profiles. Older adults who reported a comorbid symptomatology presented higher negative aging self-stereotypes and feelings of loneliness than the other three profiles. Compared with the subclinical profile, older adults who reported clinical symptomatology (anxiety, depressive, and comorbid profile) presented higher feelings of guilt associated with self-perception as a burden. The findings of this study suggest potential associations that may contribute to understanding and treating comorbid anxiety and depressive symptoms in older adults.
Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Authors: Remark Lindsey H. , Leclerc Kevin , Ramsukh Malissa , Lin Ziyan , Lee Sooyeon , Dharmalingam Backialakshmi , Gillinov Lauren , Nayak Vasudev V. , El Parente Paulo , Sambon Margaux , Atria Pablo J. , Ali Mohamed A. E. , Witek Lukasz , Castillo Alesha B. , Park Christopher Y, , Adams Ralf H. , Tsirigos Aristotelis , Morgani Sophie M. , Leucht Philipp 
Published: September 2023

AbstractSkeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental transformation are largely unknown. Single-cell RNA sequencing revealed that Notch signaling becomes elevated in SSPCs during aging. To examine the role of increased Notch activity, we deleted Nicastrin, an essential Notch pathway component, in SSPCs in vivo. Middle-aged conditional knockout mice displayed elevated SSPC osteo-lineage gene expression, increased trabecular bone mass, reduced bone marrow adiposity, and enhanced bone repair. Thus, Notch regulates SSPC cell fate decisions, and moderating Notch signaling ameliorates the skeletal aging phenotype, increasing bone mass even beyond that of young mice. Finally, we identified the transcription factor Ebf3 as a downstream mediator of Notch signaling in SSPCs that is dysregulated with aging, highlighting it as a promising therapeutic target to rejuvenate the aged skeleton.
Potential of continuous cover forestry on drained peatlands to increase the carbon sink in Finland
Authors: Lehtonen Aleksi , Eyvindson Kyle , Härkönen Kari , Leppä Kersti , Salmivaara Aura , Peltoniemi Mikko , Salminen Olli , Sarkkola Sakari , Launiainen Samuli , Ojanen Paavo , Räty Minna , Mäkipää Raisa 
Published: September 2023

AbstractLand-based mitigation measures are needed to achieve climate targets. One option is the mitigation of currently high greenhouse gas (GHG) emissions of nutrient-rich drained peatland forest soils. Continuous cover forestry (CCF) has been proposed as a measure to manage this GHG emission source; however, its emission reduction potential and impact on timber production at regional and national scales have not been quantified. To quantify the potential emission reduction, we simulated four management scenarios for Finnish forests: (i) The replacement of clear-cutting by selection harvesting on nutrient-rich drained peatlands (CCF) and (ii) the current forest management regime (BAU), and both at two harvest levels, namely (i) the mean annual harvesting (2016–2018) and (ii) the maximum sustainable yield. The simulations were conducted at the stand scale with a forest simulator (MELA) coupled with a hydrological model (SpaFHy), soil C model (Yasso07) and empirical GHG exchange models. Simulations showed that the management scenario that avoided clear-cutting on nutrient-rich drained peatlands (i.e. CCF) produced approximately 1 Tg CO2 eq. higher carbon sinks annually compared with BAU at equal harvest level for Finland. This emission reduction can be attributed to the maintenance of a higher biomass sink and to the mitigation of soil emissions from nutrient-rich drained peatland sites.
Head movement kinematics are differentially altered for extended versus short duration gait exercises in individuals with vestibular loss
Authors: Millar Jennifer L. , Zobeiri Omid A. , Souza Wagner H. , Schubert Michael C. , Cullen Kathleen E. 
Published: September 2023

AbstractHead kinematics are altered in individuals with vestibular schwannoma (VS) during short duration gait tasks [i.e., Functional Gait Assessment (FGA)], both before and after surgery, yet whether these differences extend to longer duration gait exercises is currently unknown. Here we examined the effects of vestibular loss and subsequent compensation on head kinematics in individuals with VS during gait exercises of relatively extended versus short duration (< 10 versus 30 s), compared to age-matched controls. Six-dimensional head movements were recorded during extended and short duration gait exercises before and then 6 weeks after sectioning of the involved vestibular nerve (vestibular neurectomy). Standard functional, physiological, and subjective clinical assessments were also performed at each time point. Kinematics were differentially altered in individuals with vestibular loss at both time points during extended versus short duration exercises. Range of motion was significantly reduced in extended tasks. In contrast, movement variability predominately differed for the short duration exercises. Overall, our results indicate that quantifying head kinematics during longer duration gait tasks can provide novel information about how VS individuals compensate for vestibular loss, and suggest that measurements of range of motion versus variability can provide information regarding the different strategies deployed to maintain functional locomotion.
In-air and in-water performance comparison of Passive Gamma Emission Tomography with activated Co-60 rods
Authors: Virta Riina , Bubba Tatiana A. , Moring Mikael , Siltanen Samuli , Honkamaa Tapani , Dendooven Peter 
Published: September 2023

AbstractA first-of-a-kind geological repository for spent nuclear fuel is being built in Finland and will soon start operations. To make sure all nuclear material stays in peaceful use, the fuel is measured with two complementary non-destructive methods to verify the integrity and the fissile content of the fuel prior to disposal. For pin-wise identification of active fuel material, a Passive Gamma Emission Tomography (PGET) device is used. Gamma radiation emitted by the fuel is assayed from 360 angles around the assembly with highly collimated CdZnTe detectors, and a 2D cross-sectional image is reconstructed from the data. At the encapsulation plant in Finland, there will be the possibility to measure in air. Since the performance of the method has only been studied in water, measurements with mock-up fuel were conducted at the Atominstitut in Vienna, Austria. Four different arrangements of activated Co-60 rods, steel rods and empty positions were investigated both in air and in water to confirm the functionality of the method. The measurement medium was not observed to affect the ability of the method to distinguish modified rod positions from filled rod positions. More extended conclusions about the method performance with real spent nuclear fuel cannot be drawn from the mock-up studies, since the gamma energies, activities, material attenuations and assembly dimensions are different, but full-scale measurements with spent nuclear fuel are planned for 2023.
Northward shift of the Kuroshio Extension during 1993–2021
Authors: Kawakami Yuma , Nakano Hideyuki , Urakawa L. Shogo , Toyoda Takahiro , Aoki Kunihiro , Usui Norihisa 
Published: September 2023

AbstractThe Kuroshio Extension (KE) flows eastward at the northern boundary of the North Pacific subtropical gyre. By transporting large amounts of seawater with heat, the KE contributes significantly to the formation of sea surface temperature (SST) fields. Recently, poleward shifts of major ocean gyres in the world ocean, including the North Pacific subtropical gyre, have been highlighted based on basin-scale changes in SST and sea surface height (SSH) distributions. However, a detailed investigation of the long-term meridional KE movement has not been presented. Investigation of KE path changes helps provide insights into long-term changes in the physical fields in the western North Pacific. In this study, we identified the KE path from satellite-derived SSH and surface current velocity data using a front identification method and showed that the KE migrated northward by approximately 210 km during 1993–2021. We further explored the cause of the northward KE shift based on atmospheric reanalysis data and numerical experiments using a high-resolution ocean general circulation model. It was revealed that the northward KE shift is mostly caused by the trend of wind stress curl in the North Pacific during 1993–2021.
Simulation-based assessment of the performance of hierarchical abundance estimators for camera trap surveys of unmarked species
Authors: Martijn Bollen , Jim Casaer , Natalie Beenaerts , Thomas Neyens 
Published: September 2023

AbstractKnowledge on animal abundances is essential in ecology, but is complicated by low detectability of many species. This has led to a widespread use of hierarchical models (HMs) for species abundance, which are also commonly applied in the context of nature areas studied by camera traps (CTs). However, the best choice among these models is unclear, particularly based on how they perform in the face of complicating features of realistic populations, including: movements relative to sites, multiple detections of unmarked individuals within a single survey, and low detectability. We conducted a simulation-based comparison of three HMs (Royle-Nichols, binomial N-mixture and Poisson N-mixture model) by generating groups of unmarked individuals moving according to a bivariate Ornstein–Uhlenbeck process, monitored by CTs. Under a range of simulated scenarios, none of the HMs consistently yielded accurate abundances. Yet, the Poisson N-mixture model performed well when animals did move across sites, despite accidental double counting of individuals. Absolute abundances were better captured by Royle-Nichols and Poisson N-mixture models, while a binomial N-mixture model better estimated the actual number of individuals that used a site. The best performance of all HMs was observed when estimating relative trends in abundance, which were captured with similar accuracy across these models.
Optimizing tick artificial membrane feeding for Ixodes scapularis
Authors: Garcia Guizzo Melina , Meneses Claudio , Amado Cecilio Pedro , Hessab Alvarenga Patricia , Sonenshine Daniel , Ribeiro Jose M. 
Published: September 2023

AbstractArtificial membrane feeding (AMF) is a powerful and versatile technique with a wide range of applications in the study of disease vectors species. Since its first description, AMF has been under constant optimization and standardization for different tick species and life stages. In the USA, Ixodes scapularis is the main vector of tick-borne zoonoses including the pathogens causing Lyme disease in humans and animals. Seeking to improve the overall fitness of I. scapularis adult females fed artificially, here, we have optimized the AMF technique, considerably enhancing attachment rate, engorgement success, egg laying, and egg hatching compared to those described in previous studies. Parameters such as the membrane thickness and the light/dark cycle to which the ticks were exposed were refined to more closely reflect the tick’s natural behavior and life cycle. Additionally, ticks were fed on blood only, blood + ATP or blood + ATP + gentamicin. The artificial feeding of ticks on blood only was successful and generated a progeny capable of feeding naturally on a host, i.e., mice. Adding ATP as a feeding stimulant did not improve tick attachment or engorgement. Notably, the administration of gentamicin, an antibiotic commonly used in tick AMF to prevent microbial contamination, negatively impacted Rickettsia buchneri endosymbiont levels in the progeny of artificially fed ticks. In addition, gentamicin-fed ticks showed a reduction in oviposition success compared to ticks artificially fed on blood only, discouraging the use of antibiotics in AMF. Overall, our data suggest that the AMF of adult females on blood only, in association with the natural feeding of their progeny on mice, might be used as an integrated approach in tick rearing, eliminating the use of protected species under the Animal Welfare Act (AWA). Of note, although optimized for I. scapularis adult ticks, I. scapularis nymphs, other tick species, and sand flies could also be fed using the membrane described in this study, indicating that it might be a suitable alternative for the artificial feeding of a variety of hematophagous species.
Efficacy of anti-tuberculosis drugs for the treatment of latent tuberculosis infection: a systematic review and network meta-analysis
Authors: Yoopetch Panida , Anothaisintawee Thunyarat , Gunasekara Agampodi Danushi M. , Jittikoon Jiraphun , Udomsinprasert Wanvisa , Thavorncharoensap Montarat , Youngkong Sitaporn , Thakkinstian Ammarin , Chaikledkaew Usa 
Published: September 2023

AbstractDespite the availability of three network meta-analyses (NMA) examining the efficacy, treatment completion, and adverse events associated with all latent tuberculosis infection (LTBI) treatments, there is currently no evidence to support the notion that the benefits of these treatments outweigh the potential risks. This NMA aimed to conduct a comprehensive comparison and update of the efficacy, treatment completion rates and adverse events associated with recommended treatment options for LTBI for individuals with confirmed LTBI, as outlined in the 2020 World Health Organization (WHO) Consolidated Guidelines for TB preventive treatment. A comprehensive search of the MEDLINE and Scopus databases was conducted until April 2023. The NMA was applied to estimate the risk difference and corresponding 95% confidence interval (CI) using a combination of direct and indirect evidence. The risk–benefit assessment was employed to evaluate the feasibility of the extra benefits in relation to the extra risks. The primary outcomes of interest in this study were active TB disease, completion rates, and adverse events. The meta-analysis incorporated data from 15 studies, which collectively demonstrated that the administration of a placebo resulted in a significant increase in the risk of developing TB disease by 1.279%, compared to the daily intake of isoniazid for 6 months (6H). Furthermore, treatment completion rates were significantly higher when using isoniazid plus rifapentine weekly for 3 months (3HP) and rifampicin daily for 4 months (4R), as compared to 6H. Considering adverse events, the combination of 3HP, 4R, and isoniazid administered daily for 9 months (referred to as 9H) significantly decreased adverse events by 4.53% in comparison to 6H. The risk–benefit assessment showed that alternative treatment regimens (9H, 4R, 3HR and 3HP) had a lower incidence of adverse events, while demonstrating a higher efficacy in preventing TB, as compared to 6H. This review indicates that there were no significant differences observed among various active treatment options in terms of their efficacy in preventing active TB. Moreover, completion rates were higher in 3HP and 4R, and a reduction in adverse events was observed in 3HP, 4R, and 9H.
Robust within-session modulations of IAT scores may reveal novel dynamics of rapid change
Authors: Cochrane Aaron , Cox William T. L. , Green C. Shawn 
Published: September 2023

AbstractThe Implicit Association Test (IAT) is employed in the domain of social psychology as a measure of implicit evaluation. Participants in this task complete blocks of trials where they are asked to respond to categories and attributes (e.g., types of faces and types of words). Reaction times in different blocks sharing certain response combinations are averaged and then subtracted from blocks with other response combinations and then normalized, the result of which is taken as a measure indicating implicit evaluation toward or away from the given categories. One assumption of this approach is stationarity of response time distributions, or at a minimum, that temporal dynamics in response times are not theoretically relevant. Here we test these assumptions, examine the extent to which response times change within the IAT blocks and, if so, how trajectories of change are meaningful in relation to external measures. Using multiple data sets we demonstrate within-session changes in IAT scores. Further, we demonstrate that dissociable components in the trajectories of IAT performance may be linked to theoretically distinct processes of cognitive biases as well as behaviors. The present work presents evidence that IAT performance changes within the task, while future work is needed to fully assess the implications of these temporal dynamics.
Copernicus for urban resilience in Europe
Authors: Chrysoulakis Nektarios , Ludlow David , Mitraka Zina , Somarakis Giorgos , Khan Zaheer , Lauwaet Dirk , Hooyberghs Hans , Feliu Efrén , Navarro Daniel , Feigenwinter Christian , Holsten Anne , Soukup Tomas , Dohr Mario , Marconcini Mattia , Holt Andersen Birgitte 
Published: September 2023

AbstractThe urban community faces a significant obstacle in effectively utilising Earth Observation (EO) intelligence, particularly the Copernicus EO program of the European Union, to address the multifaceted aspects of urban sustainability and bolster urban resilience in the face of climate change challenges. In this context, here we present the efforts of the CURE project, which received funding under the European Union’s Horizon 2020 Research and Innovation Framework Programme, to leverage the Copernicus Core Services (CCS) in supporting urban resilience. CURE provides spatially disaggregated environmental intelligence at a local scale, demonstrating that CCS can facilitate urban planning and management strategies to improve the resilience of cities. With a strong emphasis on stakeholder engagement, CURE has identified eleven cross-cutting applications between CCS that correspond to the major dimensions of urban sustainability and align with user needs. These applications have been integrated into a cloud-based platform known as DIAS (Data and Information Access Services), which is capable of delivering reliable, usable and relevant intelligence to support the development of downstream services towards enhancing resilience planning of cities throughout Europe.
Public health factors help explain cross country heterogeneity in excess death during the COVID19 pandemic
Authors: Sun Min Woo , Troxell David , Tibshirani Robert 
Published: September 2023

AbstractThe COVID-19 pandemic has taken a devastating toll around the world. Since January 2020, the World Health Organization estimates 14.9 million excess deaths have occurred globally. Despite this grim number quantifying the deadly impact, the underlying factors contributing to COVID-19 deaths at the population level remain unclear. Prior studies indicate that demographic factors like proportion of population older than 65 and population health explain the cross-country difference in COVID-19 deaths. However, there has not been a comprehensive analysis including variables describing government policies and COVID-19 vaccination rate. Furthermore, prior studies focus on COVID-19 death rather than excess death to assess the impact of the pandemic. Through a robust statistical modeling framework, we analyze 80 countries and show that actionable public health efforts beyond just the factors intrinsic to each country are important for explaining the cross-country heterogeneity in excess death.