bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptomatic and Histological Tissue Reaction to Upper Eyelid Platinum Weight
Authors: Ghodke Ameer , Miller Kelsey M. , Miller Matthew Q. 
Published: January 2023

Objectives: To present a case of non-infectious platinum eyelid weight rejection, the first reported case in otolaryngology literature. Methods: A case of a non-infectious tissue reaction to a platinum eyelid weight was identified. Results: A platinum eyelid weight was placed in a 72-year-old female for paralytic lagophthalmos. The patient presented with persistent edema and skin discoloration on post-operative day 8, though no drainage, tenderness, or other signs of infection were present. The weight was eventually explanted with rapid resolution of symptoms. Pathology demonstrated granulomatous inflammation with histiocytosis and foreign-body giant cells, consistent with tissue reaction to the platinum weight. Conclusions: Platinum eyelid weights are commonly used to treat paralytic lagophthalmos. While non-infectious tissue reactions to platinum are less common than with gold weights, they are still possible and should be treated with weight removal.
Tongues of Fire: Silas Malafaia and the Historical Roots of Neo-Pentecostal Power in Bolsonaro’s Brazil
Authors: Pagliarini Andre 
Published: January 2023

Evangelical Christians and especially Neo-Pentecostals in Brazil have gone from accepting a position as junior partners in a broad governing coalition led by the Partido dos Trabalhadores (Workers’ Party—PT) to asserting themselves as an indispensable pillar of the Jair Bolsonaro administration. A close examination of the career of the prominent Bolsonarist pastor Silas Malafaia suggests that if progressives want to improve their political relationship with evangelical voters they must first find discursive and material ways to neutralize or at least work around the most prominent and virulently conservative faith leaders. Os cristãos evangélicos (em particular os neo-pentecostais) no Brasil passaram de aceitar uma posição de ser parceiros menores numa coligação governamental abrangente dirigida pelo Partido dos Trabalhadores (PT) para impor-se como pilar imprescindível do governo de Jair Bolsonaro. Uma análise exhaustiva da trajetória do renomado pastor bolsonarista Silas Malafaia constata que se os progessistas quiserem melhorar a sua relação política com eleitores evangélicos, eles devem por primeiro descobrir meios discursivos e materiais para neutralizar ou, no mínimo, evitar os líderes religiosos que são os mais preeminentes e fortemente conservadores nesses grupos sociais.
Giant Fibrovascular Polyp of Hypopharynx: A Case Report and Literature Review
Authors: Yang Liyun , Zhao Runyu , Lu Dan , Zhang Yi , Hu An , Huang Shuixian 
Published: January 2023

Fibrovascular polyps (FVPs) are rare benign submucosal tumor-like lesions originating in the cervical esophagus and sporadically in the hypopharynx. In this article, we report a rare case of FVPs of the hypopharynx (hFVPs) with a mass measuring 16.0 × 4.0 × 1.8 cm in size, discussed its surgical strategy, and additionally reviewed relevant literature on important factors, such as age, sex, symptoms, size, treatments, and recurrence, associated with hFVPs.
Experimental and simulation study on the effect of different wheel profiles on the dynamics and wheel wear of high-speed trains
Authors: Wang Chengtao , Dai Huanyun , Wang Jianbin , Qi Yayun 
Published: January 2023

The wheel profile has a significant impact on the dynamics and operation economy of high-speed trains (HST). To study the effect of different wheel profiles on the operating performance of the HST. This paper proposed a combination method of experimental and simulation to study the performance of different profiles. A certain type of X-type HST with different wheel profiles S1002CN, LMB10 and XP55 to study the operating performance of the HST were investigated. A dynamic model of HST and a Jendel wear model were also developed to study the dynamics and wear characteristics of the HST. The experimental results found that the wheel re-profiling mileage of the three types of wheel profiles were 112,000 km, 140,000 km and 211,000 km, respectively. Therefore, the XP55 wheel profile was the optimum profile and the S1002CN wheel profile was the worst profile when matched with the X-type HST. The bogie hunting frequency of three wheel profiles before wheel re-profiling was 8.3 Hz, 8.5 Hz and 6.8 Hz, respectively. The vehicle dynamics performance of the XP55 profile is the best and the S1002CN profile is the worst, and wheel wear prediction results showed that XP55 had the smallest wear depth. The article provides a basis for the selection of wheel profiles for HST.
Surgical Management of Submucous Cleft Palate by Radical Muscle Dissection Veloplasty: Speech Outcomes in Patients with 22q11.2 Deletion Syndrome
Authors: Ghanem Ali M , Borg Tiffanie-Marie , Youssef Gehad , Ridout Deborah , Gilleard Onur , Birch Malcolm , Sell Debbie , Sommerlad Brian C 
Published: January 2023

Objective To evaluate the benefit of anatomical muscle dissection repair for velopharyngeal insufficiency (VPI) in patients with submucous cleft palate (SMCP) with 22q11.2 deletion syndrome. Design Retrospective blinded randomised analysis of a surgeon's management over 10 years. Setting The study was performed at a specialised Paediatric hospital in the United Kingdom. Patients Children with SMCP and 22q11.2 deletion syndrome. Interventions All participants underwent radical muscle dissection veloplasty. Outcomes measured Pre- and post- operative measurements included severity of anatomical defect, speech samples and lateral images which were digitised, randomised then externally and blindly analysed using validated techniques. Stata software was used to perform statistical analysis. Results 57 children with 22q11.2 deletion syndrome were included in this analysis. Intra-operatively, the majority of cases were identified as SMCP Grade I anomalies. Post-operatively, a statistically significant improvement in hypernasality, resting palate length, palate length at maximum closure, palate excursion and gap size at maximum closure was observed. Secondary surgery was performed for 59% of patients by ten years. Conclusion Muscle dissection repair improves hypernasality, palate closure function and the closure gap in patients with 22q11.2 deletion syndrome. Although over 50% of patients may require further surgery, muscle dissection repair should be a first step due to its utility at a younger age, when invasive investigations are impossible, its lower morbidity, speech and language benefits or altering the plans for less obstructive secondary surgery when it lead to reduced velo-pharyngeal gap and improved palate mobility even when adequate velo-pharyngeal closure was not achieved.
Validity of the coding for appendicitis, appendectomy, and diagnostic laparoscopy in the Danish National Patient Registry
Authors: Fonnes Siv , Erichsen Rune , Rosenberg Jacob 
Published: January 2023

Background and objective: We aimed to validate the diagnostic accuracy of appendicitis, its severity, its description, and the surgical approach, including open or laparoscopic appendectomy and diagnostic laparoscopy, in the Danish National Patient Registry (DNPR) against information from the electronic medical records. Methods: A random sample of 1046 patients of all ages and sexes recorded in the DNPR from the Capital Region of Denmark during 2010–2015 was investigated. Patients’ admission had to include a discharge code for appendicitis (K35−K379) according to the International Classification of Disease version 10 (ICD-10) alone or in combination with a surgical code for appendectomy or the surgical code for a diagnostic laparoscopy. We calculated the positive predictive values (PPVs) with 95% confidence intervals. Results: Data from a total of 1018 patients were available for data analysis. The ICD-10 codes for appendicitis resulted in a good PPV of >95% when combined with a surgical code. ICD-10 codes combined with the surgical codes could discriminate between uncomplicated and complicated appendicitis with some caution as the PPVs ranged from 68% to 93%. Only the surgical code for laparoscopic appendectomy yielded a good PPV (99%) for the actual surgical approach. The surgical code for a diagnostic laparoscopy alone did not cover a normal diagnostic laparoscopy. Conclusions: The diagnostic accuracy of appendicitis and appendectomy in routinely collected administrative health data is good for ICD-10 codes for appendicitis in combination with a surgical code and especially for laparoscopic appendectomy. Uncomplicated and complicated appendicitis can be distinguished with some caution.
COVID-19 Disparities Among Arab, Middle Eastern, and West Asian Populations in Toronto: Implications for Improving Health Equity Among Middle Eastern and North African Communities in the United States
Authors: Sharif Mienah Z. , Maghbouleh Neda , Baback Boozary Andrew S. 
Published: January 2023

Introduction: Equity-oriented efforts to mitigate and prevent COVID-related disparities are hindered due to methodological limitations of the categorization of racial and ethnic groups, including Arabs and Middle Eastern and North African (MENA) communities, which remain invisible in national data collection efforts. This study highlights the disparities in COVID-related outcomes in Toronto, Canada and supports ongoing calls to collect public health data among MENA communities in the United States. Methods: Data on racial/ethnic identity and hospitalizations were collected by the Toronto Public Health (TPH) of the Ontario Ministry of Public Health Case between May 20, 2020, and September 30, 2021 from people with a confirmed or probable case of COVID-19. Results: The reported COVID-19 infection rate for Arab, Middle Eastern, West Asians (i.e., categories used to self-identify as MENA in Canada) relative to Whites in Toronto was 3.51. The age-standardized hospitalization rate ratio between Arab, Middle Eastern, West Asians and Whites was 4.59. Discussion: Data from Toronto highlight that Arab, Middle Eastern, and West Asians have higher rates of COVID-19 infections and hospitalizations than their White counterparts. Comparable studies are currently not possible in the United States due to lack of data that can disaggregate MENA individuals. This study underscores the critical need to collect data among MENA communities in the United States to advance our field’s goal of promoting and advancing equity.
Vascular Closure Devices For Axillary Artery Access: A Systematic Review and Meta-Analysis
Authors: Koziarz Alex , Kennedy Sean A. , Awad El-Karim Ghassan , Tan Kong T. , Oreopoulos George D. , Kalra Sanjog , Etz Christian D. , Rajan Dheeraj K. , Mafeld Sebastian 
Published: January 2023

Purpose: To evaluate the technical success and complication rates of vascular closure devices (VCDs) in the axillary artery. Materials and Methods: MEDLINE and Embase were searched independently by two reviewers to identify observational studies from inception through October 2021. The following outcomes were meta-analyzed: technical success, hematoma, dissection, pseudoaneurysm, infection, and local neurological complications. Complications were also graded as mild, moderate, and severe. A logistic regression evaluating the influence of sheath size for the outcome of technical success rate was performed using individual patient–level data. Results: Of 1496 unique records, 20 observational studies were included, totaling 915 unique arterial access sites. Pooled estimates were as follows: technical success 84.8% (95% confidence interval [CI]: 78%–89.7%, I2=60.4%), hematoma 7.9% (95% CI: 5.8%–10.6%, I2=0%), dissection 3.1% (95% CI: 1.3%–7.3%, I2=0%), pseudoaneurysm 2.7% (95% CI: 1.3%–5.7%, I2=0%), infection <1% (95% CI: 0%–5.7%, I2=20.5%), and local neurological complications 2.7% (95% CI: 1.7%–4.4%, I2=0%). There was a significant negative association between sheath size and technical success rate (odds ratio [OR]: 0.87 per 1 French (Fr) increase in sheath size, 95% CI: 0.80–0.94, p=0.0005). Larger sheath sizes were associated with a greater number of access-site complications (adjusted odds ratio [aOR]: 1.21 per 1 Fr increase sheath size, 95% CI: 1.04–1.40, p=0.013). Conclusions: Off-label use of VCDs in the axillary artery provides an 85% successful closure rate and variable complication rate, depending on the primary procedure and sheath size. Larger sheaths were associated with a lower technical success and greater rate of access-related complications. Clinical Impact Safe arterial access is the foundation for arterial intervention. While the common femoral artery is a well established access site, alternative arterial access sites capable of larger sheath sizes are needed in the modern endovascular era. This article provides the largest synthesis to date on the use of vascular closure devices for percutaneous axillary artery access in endovascular intervention. It should serve clinicians with added confidence around this approach in terms of providing a reference for technical success and complications. Clinically, this data is relevant for patient consent purposes as well as for practice quality improvement in setting safety standards for this access site.
Marginal secondary displacement in fractures of the distal radius at follow-up – an important predictor for late displacement and malunion
Authors: Schmidt Viktor , Mellstrand-Navarro Cecilia , Mukka Sebastian , Wadsten Mats 
Published: January 2023

Treatment recommendations in fractures of the distal radius are often based on the degree of displacement and functional demands. The fracture may be within an acceptable radiological range, but a marginal deterioration in alignment then occurs between the initial visit and follow-up. This may pose a risk for late displacement that may require further treatment. We secondarily analysed prospectively collected data and included 165 patients. We found that marginal secondary displacement (odds ratio (OR) 9.7), anterior comminution (OR 8.8), loss of anterior apposition (OR 6.8) and dorsal comminution (OR 2.6) were predictors of late displacement. Marginal secondary displacement is an important predictor of late displacement and malunion in fractures of the distal radius. Clinicians should not unequivocally accept general guidelines on alignment but also assess a deterioration in fracture alignment on radiographic follow-up and be aware of the potential need for surgery to avoid malunion in cases that show early secondary displacement, even when radiographic measures are within acceptable limits. Level of evidence: III
Comparison of proximal and distal involvement of upper extremity metastatic lesions: an analysis of 55 cases
Authors: Yunyu Justine Lee , Man Janet Hung Ngai , Zhixue Lim , Sebastin Sandeep Jacob , Puhaindran Mark Edward 
Published: January 2023

We analysed the differences in clinical presentation between proximal (above elbow) and distal (below elbow) upper limb metastases in a retrospective review of patients presenting to our centre from 2011 to 2019. There were 55 cases, 64% involving the humerus and 62% occurring in men. The median age at the time of diagnosis was 64 years. Thirty-one per cent of the cases were proximal lesions. Distal upper limb metastases were more likely to be soft tissue lesions (71%) compared with proximal lesions (8%). The median age of patients with distal lesions was significantly lower at 58 years compared with 65 years for proximal lesions. Overall, non-small cell lung carcinoma was the most common primary malignancy (25%), however haematological cancers were most common in the distal group (29%). Distal upper limb metastases have distinct features that distinguish them from proximal lesions. Level of evidence: IV
Worsening of Articular Tissue Damage as Defined by Semi-Quantitative MRI Is Associated With Concurrent Quantitative Cartilage Loss Over 24 Months
Authors: Roemer Frank , Maschek Susanne , Wisser Anna , Guermazi Ali , Hunter David , Eckstein Felix , Wirth Wolfgang 
Published: January 2023

Objective To assess the association of worsening of magnetic resonance imaging (MRI) semi-quantitative (SQ) tissue features with concurrent change in quantitative (Q) cartilage thickness measurements over 24 months within the Foundation for the National Institutes of Health (FNIH) Biomarker Consortium study. Methods In all, 599 participants were included. SQ assessment included cartilage damage, meniscal extrusion and damage, osteophytes, bone marrow lesions (BMLs), and effusion- and Hoffa-synovitis. Change in medial compartment Q cartilage thickness was stratified by concurrent ipsicompartmental SQ changes. Between-group comparisons were performed using analysis of covariance (ANCOVA) with adjustment for age, sex, and body mass index (BMI). Results were presented as adjusted mean difference. Results Knees with any increase in SQ cartilage scores in the medial compartment ( n = 268) showed more Q cartilage loss compared to knees that remained stable (mean adjusted difference [MAD] = -0.16 mm, 95% confidence interval [CI]: [-0.19, -0.13] mm). Knees with any increase in meniscal extrusion in the medial compartment (n = 98) showed more Q cartilage loss than knees without (MAD = -0.18 mm, 95% CI: [-0.22, -0.14] mm. Comparable findings were seen for meniscal damage worsening. Regarding BMLs, an increase by one subregion resulted in a MAD of Q cartilage loss of -0.10 mm, 95% CI: [-0.14, -0.06] mm, while this effect almost tripled for change in two or more subregions. Increase in either effusion- and/or Hoffa-synovitis by one grade resulted in a MAD of -0.07 mm, 95% CI: [-0.10, -0.03] mm. Conclusion Worsening of SQ cartilage damage, meniscal extrusion and damage, number of subregions affected by BML, maximum size of BMLs and worsening of effusion- and/or Hoffa synovitis is associated with increased Q cartilage loss.
Prognostic Factors for the Clinical Outcome after Microfracture Treatment of Chondral and Osteochondral Defects in the Knee Joint: A Systematic Review
Authors: van Tuijn Iris M. , Emanuel Kaj S. , van Hugten Pieter P.W. , Jeuken Ralph , Emans Pieter J. 
Published: January 2023

Objective The objective of this study is to establish which patient and lesion characteristics are related to the clinical outcome after microfracture of cartilage defects in the knee. Study design Systematic review. Methods After preregistration, PubMed, Embase, and Cochrane were searched for studies that analyzed prognostic factors for the outcome of microfracture treatment in the knee. The criteria for inclusion were outcome measured using Patient-Reported Outcome Measures (PROMs), a clinical study with ≥10 participants receiving microfracture, and a minimal follow-up period of 1 year. Results For none of the investigated prognostic factors, effect size reporting was sufficiently homogeneous to conduct a meta-analysis. However, a majority of the included studies identified higher age, larger lesion size, longer preoperative symptom duration, and previous surgery on the ipsilateral knee, especially meniscectomy and anterior cruciate ligament reconstruction, as factors that are reported to be correlated to a less favorable outcome. A lesion location that does not include the trochlea or the patellofemoral joint and is not weightbearing, a nondegenerative mechanism of injury, and a single lesion were reported as factors that predict a favorable outcome. As to gender, body mass index, preoperative activity level, smoking, and concomitant knee surgery, the included articles were inconclusive or no effect was reported. Conclusions Several factors correlated with the clinical result after microfracture treatment. However, the information on the effect sizes of the influence on clinical outcome is incomplete due to poor reporting. Large-scale registries or pooling of homogeneous, well-reported data is needed to work toward prognostic models. That would be an important step toward personalized treatment.
Role of serum lactate as prognostic marker of mortality among emergency department patients with multiple conditions: A systematic review
Authors: Alshiakh Safinaz M 
Published: January 2023

Objective: In the Emergency Department, the physician’s purpose is to rapidly and accurately diagnose the severity of a patient’s condition so that proper treatment can be administered. Therefore, this study pays close attention to the association and prognostic value of blood lactate on different disease outcomes by systematically reviewing recently published studies. Methods: The search strategy was developed based on searches in the year 2022 for potential publications including original articles, case reports, and reviews using the following web databases google scholar, PubMed, and Science Direct. A total of 25 studies were identified and reviewed extensively to evaluate the link between mortality and serum lactate levels. Results: This literature review presents the strong association of elevated serum lactate levels with the in-hospital mortality rate among emergency department patients. Conclusion: These findings suggest that even a moderately raised lactate level in serum can predict the severe outcome in emergency department patients suffering from different conditions. Therefore, early (at the time of administration of hospital) and periodic serum lactate value determination through different techniques and scores is of need and should become part of routine analyses in emergency department to predict and choose therapies that could benefit critically ill patients.
Magnitude of extra-analytical errors and associated factors in medical laboratories in thirteen Public Hospitals in Addis Ababa, Ethiopia
Authors: Degfe Cheru , Mohammed Ousman 
Published: January 2023

Background: Currently, more than two-thirds of medical decisions are made based on laboratory test results. However, due to the compromised pre-analytical and post-analytical phases (or extra-analytical phase), the reporting of incorrect or inappropriate test results was still prevalent. Studies focusing on the prevalence of and factors associated with laboratory error remain very limited in Ethiopia. Objective: This study aimed to assess the magnitude of extra-analytical errors and associated factors in medical laboratory services in 13 public hospitals in Addis Ababa, Ethiopia, from January to April 2020. Materials and Methods: A hospital-based cross-sectional study was conducted in the medical laboratories of public hospitals in Addis Ababa from January to April 2020 to assess extra-analytical errors and associated factors. Data were collected from 2401 laboratory request forms ordered within the study period and 169 laboratory professionals working in public hospitals. The collected data were entered and analyzed using SPSS version 23 software. Data were analyzed using simple descriptive statistics, percentages, and frequencies and summarized using tables and text. Bivariate logistic regression analysis was conducted, and variables (with a p value below 0.25) were included in the multivariate logistic regression model. A p value <0.05 was considered a cutoff point in the final model. Results: In this study, of the errors detected, 60.3% occurred in the pre-analytical phase and 39.7% in the post-analytical phase. Extra-analytical errors in laboratory services were significantly associated with lack of written procedures for laboratory activities (adjusted odds ratio = 2.79, 95% confidence interval = 1.34–5.86), 1–2 years of work experience (adjusted odds ratio = 5.5, 95% confidence interval = 2.54–9.31), work experience (3–5 years) (adjusted odds ratio = 2.67, 95% confidence interval = 0.94–4.56), and education (diploma) (adjusted odds ratio = 6.30, 95% confidence interval = 2.17–12.26). Conclusion: This study discovered errors in the pre-analytical (60.3%) and post-analytical (39.7%) phases, and none of the requisition papers had complete data. This frequency may be affected by workload, a lack of written procedures, the number of years of work experience, and the level of education of the staff.