bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of solar water disinfection treatment system in improving rural and peri-urban household drinking water quality and reducing waterborne diarrhoeal diseases
Authors: Phiri Dickson Baxter , Bavumiragira Jean Pierre , Yin Hailong 
Published: June 2023

Abstract

Consumption of untreated microbiologically contaminated water, prevalent in many developing countries, exposes the vulnerable population to inordinate health risks including most life-threatening diarrhoeal diseases like cholera and other illnesses. In response, innovative techniques for treating water at the household level, known as household water treatment (HWT), have emerged as practical and cost-effective solutions. Solar water disinfection (SODIS) has gained recognition as one such method that utilizes sunlight to inactivate harmful micro-organisms in water. This review examines the effectiveness of SODIS as an HWT technique by analysing scientifically robust evidence documenting its microbiological efficacy and the positive health gains among SODIS users. It explores the challenges and limitations that impact its inactivation efficiency and sustainability. Its novelty lies in its expanded exploration of the available strategies and techniques for enhancing the effectiveness of SODIS to address its associated limitations and challenges. By providing a comprehensive analysis of the scientific evidence, this review presents compelling reasons for the implementation and scalability of SODIS in the developing world. This novel perspective contributes to the existing literature on improving access to safe drinking water in underserved communities, offering valuable insights into the advancement of SODIS as a practical and sustainable HWT solution.
Prediction of Toxicity of Nanomaterials Using QSAR Approach
Authors: Singh Dilpreet , Chawla Pooja A. 
Published: June 2023

Abstract:
Building mathematical models based on the analysis of physiochemical systems is known as
computational modeling. It may be used to combine different types of data and gain a thorough grasp of
how they are correlated. Computational modeling techniques cannot replace true experimental techniques
or function as a real mechanism. Despite this, they showed to be highly effective at displaying the outcomes
for a suggested technique. Nanotechnology is a developing field of producing cost-effective nanomaterials.
The toxicity of nano-based products may be significantly affected by the presence of metal
impurities and latent waste. The contaminants introduced into the nano-products during manufacturing
toxicate the cells. A limited number of techniques for the precise detection of nanotoxicity in nanomaterials
has created interest in scientists for the development of newer computational techniques like QSAR.
QSAR gives precise results based on ligand descriptors and mathematical algorithms to create functionalized
bandwidth that detects toxicity at nano-levels. Now, widespread literature revealed QSAR workflow
for the precise detection of various toxicants in nano-materials. The current mini-review focused on the
basic principles of QSAR in nanotoxicity predictions along with the applications and future prospects.
High Incidence and Predictors of Loss to Follow-up among Children and Adolescents on Life Long Antiretroviral Therapy in the Conflict-affected Northwest and Southwest Regions of Cameroon: A Retrospective Cohort Study
Authors: Tih Pius Muffih , Ayima Charlotte Wenze , Boeyeo Forsi Nwebim , Atanga Pascal Nji , Eveline Mboh Khan 
Published: June 2023

Background:
Retention in care and transition to adulthood are critical for children and adolescents living with HIV on Antiretroviral Therapy (ART) in HIV treatment programs in Sub Sahara, Africa.

Objective:
This study aimed to determine the incidence and predictors of loss-to-follow-up (LTFU) in the context of the ongoing crisis caused by an armed conflict in the Northwest and Southwest Regions of Cameroon, where staff in HIV treatment programs faced unique challenges of retention of children/adolescents.

Methods:
We employed a multi-stage mixed method design in which we conducted a retrospective cohort study to determine incidence and risk factors for LTFU through data abstraction from medical records of children and adolescents from five (5) ART treatment centers, followed by seventeen (17) key informant interviews conducted with healthcare workers to gain further insights into the reasons for LTFU among children and adolescents enrolled between January 2018 to December 2021. Kaplan–Meier plots were used to determine the probability of LTFU as a function of time. The Cox regression model was used to measure predictors of LTFU. Endpoint-recorded interviews were transcribed, translated, and analyzed using Atlas-ti Version 9.

Results:
A total of 1,030 children and adolescents (p-y) were enrolled for follow-up. 138 (13.4%) were LTFU, with an overall incidence rate of 33.0 LTFU per 1000 person years. Survival probability decreased for younger children and older adolescents. Receiving care in a rural health facility (AHR:2.14 (1.23-3.76), non-biological caregivers (AHR: 2.44; 95% CI: 1.59-3.74), short duration on ART, being on a sub-optimal regimen (AHR: 17.83; 95% CI: 11.00-29.00) and long distances to health facility (AHR:2.05; 95% CI: 1.10-3.20) were significant predictors of LTFU. Multiple Caregivers (94.1%), long distances/cost of transportation (88.2%), socio-political crises (75.5%), peer pressure, refusal, dating and marriage among adolescents (70.5%), stigma (64.7%), competitive life activities (58.8%), lack of timely disclosure (53%), poverty/lack of partner/family support (48.2%), lack of understanding on the disease process (47.0%), alternative forms of health care (29.4%), and shortage of ARVs (13.8%) were reasons for poor retention from the interviews.

Conclusion:
The overall incidence rate of LTFU was 33.0 per 1000 person years for children and adolescents initiated on lifelong ART over a period of four (4) years in the conflict-affected areas. The study portrays the need for innovative, multifaceted strategies to mitigate the predictors of this high-risk LTFU in displaced populations in the context of a sociopolitical crisis.
Modeling of Risk Factors of Childhood Stunting Cases in Malang Regency using Geographically Weighted Regression (GWR)
Authors: Anismuslim Muhamad , Pramoedyo Henny , Andarini Sri , Sudarto . 
Published: June 2023

Background:
Stunting is one of the fundamental problems in Indonesia's human development, with complex risk factors such as inadequate environmental sanitation.

Objective:
This study aims to conduct an analysis and mapping of spatially correlated sanitation risks on the prevalence of stunting among toddlers in Malang Regency, Indonesia.

Methods:
The field observations were conducted in 390 villages of urban and rural areas in Malang Regency. The secondary data of weighing toddlers in 2020 were collected from Malang Regency Health Office. The data included the identity of the residents and the history of the toddlers, while data from monthly program reports were collected from the Central Bureau of Statistics of Malang Regency. Furthermore, the study applied one and eight variables of Y and X. The Y variable was the number of stunting case toddlers, while X included the percentage of access to safe drinking water, percentage of access to permanent hygienic latrines, the topography of the region, percentage of Integrated Healthy Centre access, percentage of Exclusive Breastfeeding, Population density, ODF (Open Defecation Free) village and percentage of Integrated Healthy Centre Empowerment. Modeling the case of childhood stunting with the spatial regression method using Geographically Weighted Regression can be considered a sound approach.

Results:
The result showed that the distribution model of risk factors causing toddler stunting showed a spatial autocorrelation tendency with a clustered pattern in the area. The risk factors that were found to be spatially correlated with the incidence of stunting in children under five years of age in Malang district included access to proper drinking water (X1), access to latrines (X2), access to integrated health services (X3), exclusive breastfeeding coverage (X4), regional topography (X5), population density (X6), and empowerment of integrated health services (X8). However, the ODF (X7) did not show any correlation with stunting cases in the area.

Conclusion:
Spatial diversity and geographic variation affect the distribution pattern of risk factors causing stunting in Malang Regency. Therefore, stunting control with specific and sensitive interventions should be based on regional and local characteristics.
Extending the Privacy Calculus to the mHealth Domain: Survey Study on the Intention to Use mHealth Apps in Germany
Authors: von Kalckreuth Niklas , Feufel Markus A 
Published: June 2023

Background
With the increasing digitalization of the health sector, more and more mobile health (mHealth) apps are coming to the market to continuously collect and process sensitive health data for the benefit of patients and providers. These technologies open up new opportunities to make the health care system more efficient and save costs but also pose potential threats such as loss of data or finances.

Objective
This study aims to present an empirical review and adaptation of the extended privacy calculus model to the mHealth domain and to understand what factors influence the intended usage of mHealth technologies.

Methods
A survey study was conducted to empirically validate our model, using a case vignette as cover story. Data were collected from 250 German participants and analyzed using a covariance-based structural equation model.

Results
The model explains R2=79.3% of the variance in intention to use. The 3 main factors (social norms, attitude to privacy, and perceived control over personal data) influenced the intention to use mHealth apps, albeit partially indirectly. The intention to use mHealth apps is driven by the perceived benefits of the technology, trust in the provider, and social norms. Privacy concerns have no bearing on the intention to use. The attitude to privacy has a large inhibiting effect on perceived benefits, as well as on trust in the provider. Perceived control over personal data clearly dispels privacy concerns and supports the relationship of trust between the user and the provider.

Conclusions
Based on the privacy calculus, our domain-specific model explains the intention to use mHealth apps better than previous, more general models. The findings allow health care providers to improve their products and to increase usage by targeting specific user groups.
Efek Akupunktur Telinga dengan Press Needle terhadap Kecemasan Pasien yang Menjalani Prosedur Esofagogastroduodenoskopi
Authors: Wahdini Sri , Srilestari Adiningsih , Mihardja Hasan , Abdullah Murdani 
Published: June 2023

Latar Belakang: Prosedur invasif seperti esofagogastroduodenoskopi (EGD) dapat menimbulkan kekhawatiran dan kecemasan pada pasien. Diperlukan intervensi tambahan seperti pemberian obat sedasi, intervensi perilaku atau akupunktur untuk membuat pasien tenang dan rileks.Tujuan: Mengetahui efektivitas tindakan press needle di titik akupunktur telinga terhadap kecemasan pasien yang menjalani prosedur EGDMetode: Penelitian randomized controlled trial ini melibatkan 40 pasien yang menjalani EGD tanpa sedasi. Pasien dibagi menjadi dua kelompok, yaitu kelompok perlakuan yang diberikan perangsangan menggunakan press needle di titik akupunktur telinga dan kelompok kontrol yang diberikan jarum placebo. Titik telinga yang dipilih adalah shenmen, relaksasi, dan zero point. Penelitian dilakukan di Pusat Endoskopi Saluran Cerna, RS Dr. Cipto Mangunkusumo, Jakarta. Pasien mengisi kuesioner Spielberger State Anxiety Inventory (SAI) sebelum intervensi dan 10 menit setelah endoskopi selesai melalui wawancara langsung. Perbedaan skor SAI sebelum dan sesudah intervensi dianalisis menggunakan uji paired t-test atau mann whitney.Hasil: Skor SAI kelompok perlakuan antara sebelum dan sesudah EGD terdapat penurunan yang bermakna (man whitney p=0,003). Rerata selisih skor SAI kelompok perlakuan lebih besar bermakna dibandingkan kelompok kontrol (man whitney p<0,001)Kesimpulan: Aplikasi press needle di titik akupunktur telinga shenmen, relaksasi, dan zero point membantu menurunkan kecemasan pasien selama prosedur EGD yang diukur mengunakan kuesioner SAI
Penerapan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3) di Puskesmas Umbulharjo II Kota Yogyakarta
Authors: Susilawati Susilawati , Budiani Ratna Lestari , Paramita Iswari , Puspitasiwi Prakasita 
Published: June 2023

Latar belakang: Pengendalian risiko di fasilitas pelayanan kesehatan (fasyankes) menciptakan lingkungan kerja sehat, nyaman, selamat, dan aman sehingga fasyankes perlu menerapkan Sistem Manajemen Keselamatan dan Kesehatan Kerja (SMK3). Puskesmas Umbulharjo II sudah mengorganisasikan SMK3 sejak 2019 sehingga penerapan SMK3 dan kendala yang dihadapi perlu diteliti.Tujuan: Mengetahui penetapan kebijakan, perencanaan, pelaksanaan, pemantauan dan evaluasi, peninjauan dan peningkatan kinerja dan kendala dalam penerapan SMK3.Metode: Jenis penelitian kualitatif pendekatan studi kasus. Subjek penelitian terdiri dari manajemen beserta tim K3. Objek penelitian adalah pelaksanaan SMK3 dan dokumen terkait. Instrumen penelitian berupa daftar pertanyaan sebagai pedoman wawancara. Data dikumpulkan melalui wawancara, observasi, dan studi dokumentasi.Hasil: Penetapan kebijakan internal dan perencanaan K3 tersedia dan sudah disosialisasikan. Delapan standar K3 di fasyankes sudah dilaksanakan. Tim K3 melaksanakan pemantauan rutin setiap bulan, dan evaluasi K3 setiap semester. Belum pernah ada kegiatan peninjauan dan peningkatan kinerja oleh pihak eksternal. Kendala internalnya adalah masih banyak yang belum memahami K3 di fasyankes sehingga pelaksanaan K3 belum komprehensif dan kurangnya dukungan sumber dana. Kendala eksternal terdeteksi belum adanya dukungan dari dinas terkait selaku pembina pelaksanaan SMK3 di puskesmas.Kesimpulan: Penetapan kebijakan, perencanaan, pelaksanaan, pemantauan dan evaluasi SMK3 sudah dilaksanakan sesuai regulasi, sedangkan tahap peninjauan dan peningkatan kinerja K3 pihak eksternal belum ada sehingga peran dinas kesehatan sebagai pembina dan pengawasan sangat diperlukan.
CISPLATIN - AN OVERVIEW OF ITS EFFICIENCY AND TOXICITY
Authors: Djordjević Marija , Ilić Jovan , Stojanovic Nikola M. 
Published: June 2023

Cisplatin is the first heavy metal compound that has been found to possess antineoplastic activity. It is effective in treating testicular, ovarian, head and neck, bladder, cervical, esophageal tumors, and small cell lung carcinoma. Approximately 1% of cisplatin that enters the cell interacts with DNA, forming DNA-cisplatin bonds. Both apoptosis and necrosis can be found in the same population of cells exposed to cisplatin, and the mode of cell death depends on the cisplatin concentration and metabolic state of the target cell. In the bloodstream, the platinum component of cisplatin binds to the blood's proteins (hemoglobin, albumin and transferrin), and other significant portion binds to the glutathione and other cysteine-rich biomolecules. Cisplatin impairs the mitochondrial and cell antioxidant defense system (decreases GSH, NADPH levels, GCH/GSSG ratio, and increases GSSG levels) leading to oxidative stress. There are three main mechanisms of cell resistance to cisplatin: (1) enhanced repair of cisplatin-induced DNA lesions, (2) decrease in uptake and/or increase in efflux and (3) inactivation of cisplatin intracellularly. The usage of cisplatin is limited due to its toxicity and side effects, which include neurotoxicity (numbness and tingling, paresthesia, reduced deep tendon reflexes), nephrotoxicity (renal insufficiency, hypomagnesemia), ototoxicity (tinnitus and bilateral high-frequency hearing loss), cardiotoxicity (changes in electric heart activity, congestive heart failure), gastrotoxicity (nausea, vomiting, and dyspepsia), etc. So far, there has been no effective, clinically administered, therapy for cisplatin-induced toxicity.
Pengelolaan Desa Wisata Dalam Rangka Peningkatan Pendapatan Asli Desa di Desa Wisata Besan Kabupaten Klungkung
Authors: Puspantari Kadek Aris 
Published: June 2023

Desa wisata merupakan kawasan pedesaan yang di dalamnya menawarkan keaslian pedesaan baik kehidupan sosial, budaya, adat istiadat dan ditunjang dengan adanya potensi wisata dan fasilitas pendukung yang disajikan dalam struktur kehidupan Desa. Desa Besan merupakan salah satu desa yang sudah ditetapkan menjadi Desa Wisata . Dengan ditetapkannnya menjadi Desa Wisata,akan meningkatkan Pendapatan Asli Desa. Penelitian ini menggunakan pendekatan deskriptif kualitatif yang bertujuan untuk mendeskripsikan Pengelolaan desa wisata untuk Meningkatkan Pendapatan Asli Desa . Dalam penelitian ini merupakan penelitian kualitatif dengan menggunakan Teori Penta helik dimana dalam pengembangan Desa Wisata harus difokuskan pada pengembangan yang terintegrasi dari 5 (lima ) unsur penting yang terdiri dari Akademisi, Bisnis, Komunitas, Pemerintah, Media. Penelitian ini dilakukan di Desa Wisata Besan Kabupaten Klungkung. Jenis data yang digunakan adalah kualitatif dengan sumber data terdiri dari data primer dan skunder. Teknik pengumpulan data yang digunakan berupa Pengamatan, wawancara, Studi dokumentasi, dan penelusuran data Online. Teknik analisis data dilakukan dengan pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa Pengelolaan Desa Wisata Besan Dalam Rangka Peningkatan Asli Desa di Desa Wisata Besan dalam pengembangan yang terintegrasi dari 5 (lima ) unsur penting yang terdiri dari Akademisi, Bisnis, Komunitas, Pemerintah, Media. Dari hasil penelitian tersebut peneliti menyimpulkan bahwa Pengelolaan Desa Wisata Dalam Rangka Peningkatan Pendapatan Asli Desa Di Desa Besan di Kabupaten Klungkung sudah berjalan dengan baik namun masih mengalami beberapa hambatan-hambatan.
REMOVAL OF Cd2+ IN WASTEWATER USING ZEOLITIC IMIDAZOLATE FRAMEWORK-8 (ZIF-8) AS SYNTHESIS ADSORBENT
Authors: Fajri Rahmatul , Asfahani Fira , Amri Yulida , Jofrishal Jofrishal 
Published: June 2023

Zeolitic Imidazole Framework-8 (ZIF-8) has been synthesized by dissolving Zn(NO3)2.4H2O and 2-MeIM into a methanol solvent and solvothermal method. The synthesized ZIF-8 will be applied as a cadmium (Cd) adsorbent in Polluted water. Several characterization methods were conducted, including XRD, FTIR, and AAS. The XRD analysis shows that the prominent characteristic peaks of ZIF-8 at an angle of 2θ = 7,25o; 10,26o; 12,57o; 16,22o; and 17,86o. At the same time, the FTIR analysis showed the presence of functional groups of Zn-N, C-N, C=N, C=C, and C-H on aromatic 2-Methyl Immidazole as an indication that ZIF-8 has been completely established. Based on the result, the AAS method performed to analyze ZIF-8 ability to adsorb Cd in the water showed that Cd ions adsorption increased at pH 6 and 8 while decreasing at pH 7.
Legal Practices of Employment Agreements, Power Relations, and Identity Politics of Indonesian Women Domestic Workers
Authors: Rismawati Shinta Dewi , Rahmawati Rita , Devy Happy Sista , Septiadi Muhammad Andi , Thoha Silvia Milady Azkiya 
Published: June 2023

This research aims to analyze the legal practice of the employment agreement of women domestic workers when they enter into a work contract with their employers in Surakarta City, then to identify patterns of power relations between women domestic workers and their employers when they make their work agreements, and finally to explain the identity politics that attached to women domestic workers when they work in their employer's family. To analyze this phenomenon, a socio-legal study with a qualitative research approach is used. The results of the study show that the practice of working agreements between women domestic workers and their employers even though the work agreements are made in unwriiten, but in fact the values are in accordance with the essence of contract law as regulated in the provisions of the Civil Code (KUHPerdata). The work agreement shows a contractual and contextual dimension. The working relationship between them is based on a sense of interdependence and high trust between one another. This pattern of giving and receiving can ultimately able to reflect the existence of an equal power relationship between the two when making a work agreement. Even though women domestic workers have been labeled as helpless, they have a confident character and are autonomous in completing their work agreements. This equal relationship can make the relationship between the two very close and intense. This condition has implications for the political transformation of the identity of women domestic workers from outsiders who become part of the insider of the temporary employer's family
The Accommodation of Customary Law to Islamic Law: Distribution of Inheritance in Aceh from a Pluralism Perspectives
Authors: Ilyas Ilyas , A.Rani Faisal , Bahri Syamsul , Sufyan Sufyan 
Published: June 2023

With the emergence of receptie theory, there was a conflict between customary laws and Islamic law in the past, resulting in a protracted systemic conflict. However, the opposite occurs in the context of legal practices in Aceh, namely the accommodation of the two legal systems. This study aims to elucidate the incorporation of customary laws in Islamic law as it pertains to inheritance issues in Aceh. This study analyzes empirical legal research through the lens of legal pluralism. The data was gathered through in-depth interviews and literature reviews. This study found that various inheritance-related cases involving substitute successors, joint assets, heirs of different religions, and obligatory wills for adopted children are examples of how Islamic law accommodates customary laws. The two factors responsible for the accommodation of adat in Islamic law are the nature of the law, which is dynamic, elastic, and flexible, and the sociological condition and personality of the Acehnese, which support this integration. Moreover, this accommodation has a positive impact on the lives of people so that the maintenance and observance of adat or customs become firmer, the law functions as social control and Islamic law is cultivated in society. Theoretically, in the context of legal pluralism, accommodation between adat in Islamic law creates a space for harmonization as the main goal of this theory, not the theory of receptie which gives birth to conflicts and conflicts between legal systems.