bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intralipid and Caffeic Acid Phenethyl Ester Reverse the Neurotoxic Effects of Organophosphate Poisoning in Rats
Authors: Basarslan SK. , Basarslan F 
Published: July 2023

ABSTRACT

Background:
Organophosphate (Op)-containing herbicides continue to be widely used in the world. Although its usage and intoxication are widespread, the studies on organophosphate-induced neurotoxicity and treatment protocols are very few in the literature.

Aims:
This study aimed to investigate any potential effects of caffeic acid phenyl ester with/without intralipid on neurotoxicity produced by acute intoxication of glyphosate isopropylamine in an experimental rat model.

Materials And Methods:
Forty-nine wistar albino rats were randomly allotted into seven experimental groups: I, control; II, intralipid (IL); III, caffeic acid phenyl esther (CAPE); IV, glyphosate isopropylamine (GI); V, GI + IL; VI, GI + CAPE; and VII, GI + IL + CAPE. Total antioxidant and oxidant status levels were gauged, and the oxidative stress index was calculated in the serum samples. On the other hand, the tissues were analyzed with hematoxylin-eosin (HE) staining protocol and counted up by immunohistochemical method. Statistical evaluations were conducted using SPSS 11.5 for Windows (SPSS, Chicago, IL, USA).

Results:
Compared to the control, IL, and GI + IL + CAPE groups, the GI group significantly decreased the total antioxidant levels in brain tissues. In a supportive nature, a significant increase in the oxidative site index (OSI) in the GI group compared to other groups. Especially standing out point of these findings is the significant difference between the GI + IL + CAPE and the GI group. Parallelly, histopathological analysis extended severe neurotoxicity in the GI group. Neurotoxic status was reduced significantly in the GI + CAPE + IL group. The histopathologic examinations confirmed biochemical results. The results also revealed that CAPE and IL, probably their antioxidant effects, have a rehabilitative effect on neurotoxicity caused by GI.

Conclusion:
Therefore, CAPE and IL may function as potential cleansing and scavenger agents for supportive therapy regarding tissue damage or facilitate the therapeutic effects of the routine treatment of the patient with GI poisoning.
Awareness of ideal sitting posture among professional bus drivers in Pune city
Authors: Tawade Shubham Shailesh , Patel Farheen Salim 
Published: July 2023

BACKGROUND:
Ergonomics is a scientific study related to the understanding of interactions among humans and other elements of a work system. From various studies, it was revealed that there are the highest rates of musculoskeletal disorders in bus drivers. One of the causes of musculoskeletal disorders is the poor posture from an improperly adjusted seat. An adequate knowledge of the principles of ergonomics of workstation setup can prevent a lot of discomfort and maximize productivity.

OBJECTIVES:
The objective of this study was to know whether the professional bus drivers are aware of: (a) ideal sitting posture of the body while driving and (b) alignment of the driving seat.

MATERIALS AND METHODS:
The present study was conducted at Pune Mahanagar Parivahan Mahamandal Limited depots on 133 bus drivers, and data were collected by interview method using a self-made questionnaire.

RESULTS:
It was found that 93.98% of participants were aware about correct sitting posture while driving in general. The 63.90% were aware about the ideal seat height, 83.83% know about the proper knee position, 84% were aware about the correct positioning of the feet while driving, and 67.66% know about the proper angle of inclination of seat back and the usefulness of adding a lumbar support.

CONCLUSION:
The study concluded that majority of the bus drivers are aware about the ideal sitting posture while driving. It indicates the need to ergonomically design the workplace of drivers to decrease the risk of work-related musculoskeletal disorders which may help in improving their quality of life and the worker's productivity.
PERSPECTIVAS DE GESTANTES EM PRÉ-NATAL NA ATENÇÃO BÁSICA NO CONTEXTO DA PANDEMIA DE COVID-19
Authors: Sene Matheus , Rodrigues Maria Manoela Duarte , Pina-Oliveira Alfredo Almeida 
Published: July 2023

Objetivo: compreender as perspectivas de gestantes sobre a pandemia de COVID-19 durante o pré-natal na Atenção Básica. Método: pesquisa qualitativa descritiva e exploratória realizada em Unidade Básica de Saúde no interior paulista entre agosto e setembro de 2020. Participaram 19 gestantes de modo presencial e com os cuidados de biossegurança. Adotou-se a análise temática suportado pelo software on-line Taguette® e a análise lexical de conteúdo por meio do IRAMUTEQ. Resultados: emergiram três temas centrais: (1) desafios da maternidade na pandemia, (2) efeitos do isolamento social e (3) estratégias para enfrentar a COVID-19. Considerações finais: os cuidados durante o pré-natal podem incorporar novas formas de lidar com medos, dúvidas e desejos relacionados à COVID-19 e extrapolar a dimensão individual para propor ações coletivas e intersetoriais baseados na Atenção Básica.
The effect of cosmetics on the skin of the face
Authors: Pabijanskaitė Ugnė , Gierasimovič Zita 
Published: July 2023

Couperosis is a skin condition in which there is a disorder of the skin covering the face with a network of dilated capillaries; it is usually an inherited skin condition. The development of couperosis is influenced by the weakening of capillaries, chronic diseases that predispose to blood circulation disorders.
Aim of the study. To assess the effect of cosmetic products on couperose facial skin.
Methods. Mixed method research. In 2023, one 58-year-old subject was used for this study, meeting the criteria required for the study: age, with a couperose skin condition, job specifics that would allow not to wear heavy make-up every day, to be in the sun for a long time, not to have allergic reactions to the components of the used products. The following were used for the study: a skin diagnostic device, a customer card, a course of ten procedures with the active substance, repeated weekly.
Results. Mixed skin type, deformational aging. Couperosis can be seen on the cheeks, in the wings of the nose, there are telangiectasias in the area of the wings of the nose, on the left cheek of the eye. The skin is dehydrated, sebum secretion is increased in the forehead, nose and chin area. During the procedures, multi-component X active substances are used to reduce the effect of couperose on the skin, moisturize, stimulate skin regeneration, collagen and elastin synthesis, shrink capillaries and strengthen the hydrolipidic barrier.
Conclusions. 1. Damaged facial skin is caused by an improper use of cosmetic products and exposure to the external risk factors. 2. The multicomponent, acid-based active substances used to restore the hydrolipidic barrier and improve the condition of couperose skin strengthened capillaries, improved skin metabolism, accelerated cell regeneration, and reduced the harmful effects of couperose on the skin.
Hepatoprotective action of some Ayurvedic drugs: A review
Authors: Sathavane Geeta Vishwanath , Patil Shweta , Wankhede Arun , Dikondwar Ankush 
Published: July 2023

Yakrut is the Ayurvedic name for liver. It is involved in several physiological processes in the body, including metabolic activities, secretory, retention, purification, and elimination of foreign and endogenous materials. As a result, any impairment or degradation of its functionality leads to a wide range of liver problems. The principal hepatic illnesses that cause a high fatality rate include hepatotoxicity, jaundice, and hepatitis. Liver problems are still a growing health problem around the world. The treatment of liver problems using traditional or synthetic medications is ineffective and can have major negative impact.Ayurvedic herbal medicines, on the other hand, have a variety of possible benefits in liver diseases, despite the absence of a proven hepatoprotective medication in modern medicine. A variety of hepatoprotective herbs have been identified. In this review paper, we have attempted to collect and consolidate information on hepatoprotective herbs that will be useful in the Indian medical system.
Keywords- Hepatoprotetive plants, Liver, Indian systems of medicine, Yakrut, Herbal drugs
A Review on ethnomedicinal claims of Merremia gangetica Linn.
Authors: Kumar Suraj , Nathulal Das Ashokkumar 
Published: July 2023

Aim: The medicinal plant Merremia gangetica Linn., family - Convolvulaceae, traditionally being used by the local healers due to its multiple therapeutic indications. Present review aims to collect currently available data on ethno-medicinal information and research updates on M. gangetica. Material and Methods: Available books related to traditional folklore uses of M. gangetica were searched from ethno-medicinal plants and published research articles. Along with various researches, name of reporting tribe and their place using the plant, vernacular names, parts used along with the therapeutic uses with specific methods of administration, if any, through either external or internal usages were also noted. Results: Across the globe in 2 countries and 8 states of India, M. gangetica has been reported for its traditional folklore therapeutic uses and in the management of 32 diseases conditions, various parts of the plants like whole plant, leaf, root and seed alone or along with other drugs are used either through external applications or internal administration. Maximum indicated in the treatment of rheumatism, neuralgia, headache, cough, etc. were reported. Whole plant has maximum application in 14, followed by leaf in 8, root in 4 and seed in 1 diseases condition. Pharmacological studies such as anti-arthritis, hepatoprotective, nephroprotective activities, etc. were also reported. Conclusion: M. gangetica is a folklore ethnomedicinal plant being used as medicine in rheumatism, neuralgia, headache, cough, etc. and also to establish its ethnic claims, plant need scientific evaluation through pharmacological and clinical studies.
EFEKTIVITAS PENDEKATAN ANANLISIS KESALAHAN BAHASA DALAM PEMBELAJRAN INSYA’ TAHRIRI UNTUK MENINGKATKAN KEMAMPUAN MENULIS
Authors: Budiman Agus , Ikrom Muhammad 
Published: July 2023

Bahasa Arab adalah pelajaran yang diunggulkan dalam pembelajaran dilembaga pendidikan Pesantren. Bahasa Arab yang diajarkan dan dipelajari oleh penutur selain bahasa Arab tidaklah mudah. Santri dalam belajar bahasa kedua pasti akan mengalami kesulitan. Tidak sedikit dari mereka terdapat kesalahan selama penerapan bahasa ini, dan kesalahan-kesalahan ini baik secara lisan maupuntulisan .Penelitian ini berkaitan dengan analisis kesalahan bahasa dalam pelajaran Insya’ Arabi At-tahriri santri di kelas dua putra Pondok Pesantren Al-Amanah Al-Gontory,Tangerang. Peneliti mengambil sample pada penelitian ini 64 santri kelas 2 TMI. Metode yang digunakan dalam penelitian ni adalah eksperimen. Peneliti menggunakan metode eksperimen yang betul-betul atau True Experimental design. Desain eksperimen yang dipakai dalam penelitian ini yaitu posttest only control design. Peneliti menggunakan dua kelompok, masing-masing dipilih secara random. Sementara itu, teknik analisis data yang digunakan dalam penelitian ini adalah statistik deskriptif. Berdasarkan hasil penelitian diketahui bahwa pembelajaran Insya’ menggunakan pendekatan analisis kesalahan untuk meningkatkan kemampuan menulis santri. Kemudian terdapat perbedaan nilai rata-rata antara postes pada kelompok eksperimen dan kelompok kontrol (72,69 > 56,39). Hal ini menunjukkan bahwa pendekatan analisis kesalahan dalam pembelajaran Insya’ untuk meningkatkkan kemampuan menulis efektif
Burden of oral disorders, 1990–2019: estimates from the Global Burden of Disease Study 2019
Authors: Tu Chengwei , Wang Gege , Hu Zhangyi , Wang Shuyu , Yan Qianqian , Liu Xueying 
Published: July 2023

IntroductionThe aim of this study was to understand the global incidence and disability-adjusted life years (DALY) of oral disorders by age, gender, region, and Sociodemographic Index (SDI) from 1990 to 2019.Material and methodsThe estimated annual percentage change (EAPC) and 95% confidence intervals (CIs) were used to assess the trends in age-standardized incidence and DALY rates from 1990 to 2019.ResultsThe global age-standardized incidence rate (EAPC = 0.01) of oral disorders increased slightly from 1990 to 2019. From 1990 to 2019, the age-standardized DALY rate decreased in high-SDI (EAPC = –0.43) and high-middle-SDI (EAPC = –0.14) regions, but it showed increasing trends in low-SDI (EAPC = 0.22), low-middle-SDI (EAPC = 0.36), and middle-SDI (EAPC = 0.17) regions. The EAPC in the age-standardized DALY rate was negatively correlated with the regional SDI value ( = –0.402, p = 0.001). From 1990 to 2019, the region with the largest increase in age-standardized DALY rate was South Asia (EAPC = 0.67), while the country with the greatest increase in age-standardized DALY rate was India (EAPC = 0.82).ConclusionsFrom 1990 to 2019, the global age-standardized incidence rate of oral disorders showed a slight increasing trend. It is necessary to control the increase in DALY and the disease burden associated with oral disorders in low-, low-middle-, and middle-SDI regions, such as South Asia, particularly in India.
Point-of-Care HIV and Syphilis Screening
Authors: Brett Kendra , Askin Nicole 
Published: July 2023

In prenatal care, point-of-care tests for syphilis have the potential to be cost-effective and may increase the proportion of people screened and treated for syphilis.
Decision-makers should consider the potential for point-of-care HIV and syphilis screening to increase access to timely treatment for birthing parents and newborns, particularly in rural and remote communities and certain equity-deserving groups. However, the identified studies for this report provided few details about included populations, limiting an assessment of potential health inequities related to point-of-care screening.
None of the included studies used point-of-care tests for HIV or syphilis in people in labour.
We did not find any studies on the clinical utility or cost-effectiveness of dual point-of-care tests for HIV and syphilis that met our inclusion criteria.
We did not find any studies on the diagnostic test accuracy, clinical utility, or cost-effectiveness of standalone point-of-care tests for HIV that met our inclusion criteria.
Electrostimulation Devices for Wounds
Authors: Hao Qiukui , Horton Jennifer , Hamson Angie 
Published: July 2023

We found that electrostimulation as an adjunct to usual wound care might be better than usual care alone for wound management without increasing the risk of adverse events.
Electrostimulation therapy may have greater effectiveness for patients with chronic wounds versus acute wounds or those with venous leg ulcers (VLUs) who do not have surgery compared with those who do have surgery.
Electrostimulation using pulsed current may have greater effectiveness on wound management than using direct current for patients with pressure ulcers.
Limited evidence from subgroup analyses suggests that the effectiveness of electrostimulation may be similar to negative pressure wound therapy (NPWT) in wound surface area (WSA) and time to complete wound healing.
One economic evaluation study used a within-trial time horizon (up to 24 weeks) and, based on the UK National Health Service perspective, suggests that electrostimulation is less costly and more effective than placebo at 24 weeks. We did not find any studies reporting on the cost-effectiveness between electrostimulation and NPWT that met the inclusion criteria for this report.
One guideline suggests using electrostimulation as an adjunct intervention for managing postoperative pain in patients who have undergone elective caesarean section; another guideline strongly recommends against physical therapies (including electrostimulation) for diabetic foot ulcer management.
A patient with lived experience of using an electrostimulation device for the treatment of a wound was involved in this report. He identified outcomes that are important to patients, primarily avoiding hospitalization and surgery, which were not outcomes reported in the identified literature. Considerations included the accessibility of the devices, training, and integration into homecare services.
Teaching text structure in science education
Authors: Kooiker-den Boer Hilde , Sanders Ted , Evers-Vermeul Jacqueline 
Published: July 2023

Outcomes from a body of research on reading education stress the importance of text structure instruction and the integration of reading instruction in content learning in primary schools. We conducted an analysis of Dutch textbooks and workbooks of the seven most frequently used science teaching programs developed for grades 3-6 in order to find out to what extent these materials are appropriate for text structure instruction. The results show that the materials do offer opportunities for text structure instruction but are not suitable for a step-by-step implementation and practice of knowledge and skills related to text structure. The textbooks offer too few clear organized single-structured texts and not all text structures are sufficiently represented. Also, the programs differ strongly in text length, text segmentation and use of introductions. Illustrations and assignments hardly connect to the text structure. We finish the paper with recommendations for educational publishers.
Tingkat Kepuasan Pasien Terhadap Pelayanan Kefarmasian di Apotek Kimia Farma X Kecamatan Banjarmasin Timur
Authors: Elisa Nor , Mustaqimah Mustaqimah 
Published: July 2023

Latar Belakang : Mutu pelayanan pada bidang kesehatan adalah pelayanan kesehatan yang menimbulkan kepuasan pada pasien. Kepuasan sangat penting dalam pelayanan kesehatan karena dapat mengukur kualitas pelayanan kesehatan. Tujuan : Tujuan dari penelitian ini adalah untuk melihat dan mengidentifikasi tingkat kepuasan pasien terhadap pelayanan kefarmasian di Apotek Kimia Farma X Kecamatan Banjarmasin Timur. Metode : Jenis penelitian ini adalah penelitian observasional dengan metode penelitian deskriptif.. Penelitian deskriptif adalah penelitian yang dilakukan dengan tujuan membuat gambaran atau deskripsi tentang suatu keadaan secara objektif dengan penelitian cross sectional dengan jumlah 32 responden. Hasil : Berdasarkan hasil penelitian yang didapatkan bahwa 11 dari 20 pernyataan yang diajukan kepada responden berada pada tingkat kepuasan “Cukup Puas” dengan persentase 55 %. Kesimpulan : Berdasarkan hasil penelitian yang sudah dilakukan maka dapat disimpulkan bahwa tingkat kepuasan pasien terhadap kualitas pelayanan kefarmasian di Apotek Kimia Farma X Kecamatan Banjarmasin Timur adalah ‘Cukup Puas’
Evaluasi Sifat Fisik Dan Uji Iritasi Sediaan Sabun Wajah Ekstrak Etanol Biji Salak Pondoh (Salacca zalacca (Gaert.) Voss)
Authors: Khaqiqi Rafi Firman , Nawangsari Desy , Prabandari Rani 
Published: July 2023

Salah satu bagian yang berguna dari salak pondoh adalah bijinya. Biji salak pondoh memiliki aktivitas antioksidan yang dapat menangkal radikal bebas. Potensi tersebut dapat dimanfaatkan dalam pembuatan kosmetik pembersih wajah. Tujuan dari penelitian ini adalah memformulasikan ekstrak etanol biji salak pondoh menjadi sediaan sabun wajah, kemudian dilakukan uji sifat fisik dan uji iritasi akut dermal. Ekstrak etanol biji salak pondoh diformulasikan dalam beberapa konsentrasi, yaitu 1%, 3% dan 5%. Evaluasi sifat fisik yang dilakukan meliputi uji organoleptik, uji pH, uji daya busa, uji viskositas dan uji daya sebar. Sedangkan uji iritasinya menggunakan hewan uji berupa kelinci. Data yang diperoleh diuji statistik dengan metode one-way ANOVA untuk mengetahui perbedaan setiap formulanya. Hasil yang diperoleh berupa sediaan sabun wajah cair berwarna cokelat (dengan ekstrak) dan putih (tanpa ekstrak). Evaluasi sifat fisik sediaan menghasilkan pH dan daya busa yang sesuai standar namun viskositas dan daya sebarnya tidak sesuai. Tidak terpenuhinya standar viskositas dan daya sebar sediaan disebabkan oleh Viscosity Modifier (NaCl) yang perlu penyesuaian lebih lanjut. Sediaan ini bersifat iritan sedang pada kulit hewan uji berdasarkan skor indeks iritasi primernya.
Kata kunci: biji salak pondoh, sabun wajah, evaluasi fisik, uji iritasi akut dermal
Kajian Hubungan Kuantitatif Struktur Dan Aktivitas (HKSA) Senyawa Kurkumin Dan Turunannya Sebagai Agen Anti Tumor Darah Terhadap Penghambatan Pertumbuhan Sel K562
Authors: Puspitasari Ismi , Astuti Sari , Harmastuti Nuraini 
Published: July 2023

Kurkumin dilaporkan dapat menekan pertumbuhan sel tumor darah. Tujuan penelitian ini yaitu mengetahui sifat fisika kimia turunan kurkumin yang berpengaruh terhadap aktivitas antitumor sel darah yang dinyatakan sebagai model persamaan HKSA terbaik. Penelitian ini menggunakan senyawa kurkumin dan dua belas turunannya yang telah memiliki parameter aktivitas antitumor sel darah (K562) sebagai IC50. Parameter sifat fisika kimia seri senyawa kurkumin dan turunannya sebagai deskriptor meliputi muatan bersih atom pada struktur kerangka induk kurkumin, EHOMO, ELUMO, Log P, E Hid, a, MR, Volume, luas permukaan (SA), energi yotal, momen dipol (u), Hf, dan Massa yang merupakan hasil perhitungan optimasi geometri menggunakan metode semiempiris PM3 dengan aplikasi hyperchem. Model persamaan HKSA dibangun menggunakan analisis perhitungan statistic BuilQSAR. Model persamaan HKSA terbaik selanjutnya dilakukan validasi internal dan eksternal.
Analisa statistik dengan BuldQSAR, diperoleh deskriptor yang memiliki pengaruh paling besar yaitu muatan bersih atom, EHOMO, luas permukaan, momen dipol dan Hf dengan persamaan regresi linear: Log 1/IC50 : + 1.7622 (± 0.3655) qC4 - 0.9457 (± 0.1047) E Homo + 0.0013 (±0.0002) SA + 0.0575 (± 0.0216) u - 0.0068 (± 0.0004) Hf - 11.4161 (± 1.0440) , n = 10; R = 0.999; R2= 0,9990; SPress = 0.0232, serta persamaan regresi non linear : Log 1/IC50 = + 15.1400 (± 4.9008)qC7 + 7.4959 (± 5.6081) qC8 -0.5839 (± 0.1397) qC15 + 0.0005 (± 0.0003) SA - 0.0054 (± 0.0008) Hf - 5.7246 (± 3.2476), n = 10; R =0,999, R2 = 0,9977; SPress = 0.0341.
Potensi Anti Bakteri Hard Candy Ekstrak Asam Jawa (Tamarindus indica L.) dengan Minyak Sereh Wangi (Oleum Citronellae)
Authors: Saptawati Tunik , Handayani Dwi Nurul , Gloria Fransisca , Suwarni Sri 
Published: July 2023

Asam Jawa dan sereh wangi merupakan tanaman Indonesia yang banyak ditanam dan mudah diperoleh masyarakat. Minyak sereh wangi banyak dimanfaatkan sebagai anti bakteri karena kandungan metabolit sekundernya. Penelitian ini bertujuan untuk mengetahui potensi anti bakteri hard candy dengan bahan aktif ekstrak asam Jawa dan minyak sereh wangi. Ekstrak buah asam jawa dibuat dengan metode maserasi menggunakan pelarut etanol 96%. Hard candy dibuat dalam 3 formula dengan bahan aktif ekstrak asam Jawa dan minyak sereh wangi 0,1% (F1), minyak sereh wangi 0,2%(F2), dan minyak sereh wangi 0,3% (F3), Pengujian aktivitas antibakteri hard candy menggunakan metode difusi cakram dengan mengukur diameter zona hambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli. Hasil uji diameter zona hambat F1, F2, dan F3 terhadap Escherichia coli berturut-turut sebesar 4,25, 4,38, dan 5,35 mm. Hasil uji diameter zona hambat F1, F2, dan F3 terhadap Staphylococcus aureus berturut-turut sebesar 2,30, 2,67, dan 2,90 mm. Hal ini menunjukkan hard candy dengan ekstrak asam jawa dan minyak sereh wangi berpotensi sebagai anti bakteri. Perbedaan diameter zona hambat antar formula dianalisis menggunakan One Way Anova dan diperoleh nilai signifikansi < 0,05, maka terdapat perbedaan aktivitas anti bakteri yng signifikan antar kelompok. Konsentrasi minyak sereh berpengaruh terhadap aktivitas antibakteri di mana semakin tinggi konsentrasi minyak sereh dalam formula maka semakin besar aktivitas antibakteri terhadap Staphylococcus aureus dan Escherichia coli.

Kata kunci : Minyak sereh wangi,Asam Jawa, Hard Candy, Antibakteri.