bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-world benefit of intracranial pressure monitoring in the management of severe traumatic brain injury: a propensity score matching analysis using a nationwide inpatient database
Authors: Shibahashi Keita , Ohbe Hiroyuki , Matsui Hiroki , Yasunaga Hideo 
Published: June 2023

OBJECTIVE
Intracranial pressure (ICP) monitoring is recommended for the management of severe traumatic brain injury (TBI). The clinical benefit of ICP monitoring remains controversial, however, with randomized controlled trials showing negative results. Therefore, this study investigated the real-world impact of ICP monitoring in managing severe TBI.

METHODS
This observational study used the Japanese Diagnosis Procedure Combination inpatient database, a nationwide inpatient database, from July 1, 2010, to March 31, 2020. The study included patients aged 18 years or older who were admitted to an intensive care or high-dependency unit with a diagnosis of severe TBI. Patients who did not survive or were discharged on admission day were excluded. Between-hospital differences in ICP monitoring were quantified using the median odds ratio (MOR). A one-to-one propensity score matching (PSM) analysis was conducted to compare patients who initiated ICP monitoring on the admission day with those who did not. Outcomes in the matched cohort were compared using mixed-effects linear regression analysis. Linear regression analysis was used to estimate interactions between ICP monitoring and the subgroups.

RESULTS
The analysis included 31,660 eligible patients from 765 hospitals. There was considerable variability in the use of ICP monitoring across hospitals (MOR 6.3, 95% confidence interval [CI] 5.7–7.1), with ICP monitoring used in 2165 patients (6.8%). PSM resulted in 1907 matched pairs with highly balanced covariates. ICP monitoring was associated with significantly lower in-hospital mortality (31.9% vs 39.1%, within-hospital difference −7.2%, 95% CI −10.3% to −4.2%) and longer length of hospital stay (median 35 vs 28 days, within-hospital difference 6.5 days, 95% CI 2.6–10.3). There was no significant difference in the proportion of patients with unfavorable outcomes (Barthel index < 60 or death) at discharge (80.3% vs 77.8%, within-hospital difference 2.1%, 95% CI −0.6% to 5.0%). Subgroup analyses demonstrated a quantitative interaction between ICP monitoring and the Japan Coma Scale (JCS) score for in-hospital mortality, with a greater risk reduction with higher JCS score (p = 0.033).

CONCLUSIONS
ICP monitoring was associated with lower in-hospital mortality in the real-world management of severe TBI. The results suggest that active ICP monitoring is associated with improved outcomes after TBI, while the indication for monitoring might be limited to the most severely ill patients.
The ivy sign as a radiological marker for follow-up of postoperative cerebral perfusion status in adult moyamoya disease
Authors: Lee Sung Ho , Cho Won-Sang , Lee Hee Chang , Oh Hansan , Bae Jin Woo , Choi Young Hoon , Paeng Jin Chul , Gil Joonhyung , Kim Kangmin , Kang Hyun-Seung , Kim Jeong Eun 
Published: June 2023

OBJECTIVE
Little is known about the relationship between postoperative changes in cerebral perfusion and the ivy sign representing leptomeningeal collateral burden in moyamoya disease (MMD). This study aimed to investigate the usefulness of the ivy sign in evaluating cerebral perfusion status following bypass surgery in patients with adult MMD.

METHODS
Two hundred thirty-three hemispheres in 192 patients with adult MMD undergoing combined bypass between 2010 and 2018 were retrospectively enrolled. The ivy sign was represented as the ivy score on FLAIR MRI in each territory of the anterior, middle, and posterior cerebral arteries. Ivy scores, as well as clinical and hemodynamic states on SPECT, were semiquantitatively compared both preoperatively and at 6 months after surgery.

RESULTS
Clinical status improved at 6 months after surgery (p < 0.01). On average, ivy scores in whole and individual territories were decreased at 6 months (all p values < 0.01). Cerebral blood flow (CBF) postoperatively improved in three individual vascular territories (all p values ≤ 0.03) except for the posterior cerebral artery territory (PCAt), and cerebrovascular reserve (CVR) improved in those areas (all p values ≤ 0.04) except for the PCAt. Postoperative changes in ivy scores and CBF were inversely correlated in all territories (p ≤ 0.02), except for the PCAt. Furthermore, changes in ivy scores and CVR were only correlated in the posterior half of the middle cerebral artery territory (p = 0.01).

CONCLUSIONS
The ivy sign was significantly decreased after bypass surgery, which was well correlated with postoperative hemodynamic improvement in the anterior circulation territories. The ivy sign is believed to be a useful radiological marker for postoperative follow-up of cerebral perfusion status.
Outcomes of endoscopic treatment for early correction of craniosynostosis in children: a 26-year single-center experience
Authors: Domínguez Leonardo , Rivas-Palacios Claudio , Barbosa Mario M. , Escobar Maria Andrea , Puello Florez Elvira , García-Ballestas Ezequiel 
Published: June 2023

OBJECTIVE
Surgery is the cornerstone of craniosynostosis treatment. In this study, two widely accepted techniques are described: endoscope-assisted surgery (EAS) and open surgery (OS). The authors compared the perioperative and reconstructive outcomes of EAS and OS in children ≤ 6 months of age treated at the Napoleón Franco Pareja Children’s Hospital (Cartagena, Colombia).

METHODS
According to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement, patients with defined criteria who underwent surgery to correct craniosynostosis between June 1996 and June 2022 were retrospectively enrolled. Demographic data, perioperative outcomes, and follow-up were obtained from their medical records. Student t-tests were used for significance. Cronbach’s α was used to assess agreement between estimated blood loss (EBL). Spearman’s correlation coefficient and the coefficient of determination were used to establish associations between the results of interest, and the odds ratio was used to calculate the risk ratio of blood product transfusion.

RESULTS
A total of 74 patients met the inclusion criteria; 24 (32.4%) belonged to the OS group and 50 (67.6%) to the EAS group. There was a high interobserver agreement quantifying the EBL. The EBL, transfusion of blood products, surgical time, and hospital stay were shorter in the EAS group. Surgical time was positively correlated with EBL. There were no differences between the two groups in the percentage of cranial index correction at 12 months of follow-up.

CONCLUSIONS
Surgical correction of craniosynostosis in children aged ≤ 6 months by EAS was associated with a significant decrease in EBL, transfusion requirements, surgical time, and hospital stay compared with OS. The results of cranial deformity correction in patients with scaphocephaly and acrocephaly were equivalent in both study groups.
Complications associated with single-position prone lateral lumbar interbody fusion: a systematic review and pooled analysis
Authors: Farber S. Harrison , Valenzuela Cecchi Bayron , O’Neill Luke K. , Chapple Kristina M. , Zhou James J. , Alan Nima , Gooldy Timothy C. , DiDomenico Joseph D. , Snyder Laura A. , Turner Jay D. , Uribe Juan S. 
Published: June 2023

OBJECTIVE
Lateral lumbar interbody fusion (LLIF) is a workhorse surgical approach for lumbar arthrodesis. There is growing interest in techniques for performing single-position surgery in which LLIF and pedicle screw fixation are performed with the patient in the prone position. Most studies of prone LLIF are of poor quality and without long-term follow-up; therefore, the complication profile related to this novel approach is not well known. The objective of this study was to perform a systematic review and pooled analysis to understand the safety profile of prone LLIF.

METHODS
A systematic review of the literature and a pooled analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. All studies reporting prone LLIF were assessed for inclusion. Studies not reporting complication rates were excluded.

RESULTS
Ten studies meeting the inclusion criteria were analyzed. Overall, 286 patients were treated with prone LLIF across these studies, and a mean (SD) of 1.3 (0.2) levels per patient were treated. The 18 intraoperative complications reported included cage subsidence (3.8% [3/78]), anterior longitudinal ligament rupture (2.3% [5/215]), cage repositioning (2.1% [2/95]), segmental artery injury (2.0% [5/244]), aborted prone interbody placement (0.8% [2/244]), and durotomy (0.6% [1/156]). No major vascular or peritoneal injuries were reported. Sixty-eight postoperative complications occurred, including hip flexor weakness (17.8% [21/118]), thigh and groin sensory symptoms (13.3% [31/233]), revision surgery (3.8% [3/78]), wound infection (1.9% [3/156]), psoas hematoma (1.3% [2/156]), and motor neural injury (1.2% [2/166]).

CONCLUSIONS
Single-position LLIF in the prone position appears to be a safe surgical approach with a low complication profile. Longer-term follow-up and prospective studies are needed to better characterize the long-term complication rates related to this approach.
Calibration of a comprehensive predictive model for the development of proximal junctional kyphosis and failure in adult spinal deformity patients with consideration of contemporary goals and techniques
Authors: Tretiakov Peter S. , Lafage Renaud , Smith Justin S. , Line Breton G. , Diebo Bassel G. , Daniels Alan H. , Gum Jeffrey , Protopsaltis Themistocles , Hamilton D. Kojo , Soroceanu Alex , Scheer Justin K. , Eastlack Robert K. , Mundis Gregory , Nunley Pierce D. , Klineberg Eric O. , Kebaish Khaled , Lewis Stephen , Lenke Lawrence , Hostin Richard , Gupta Munish C. , Ames Christopher P. , Hart Robert A. , Burton Douglas , Shaffrey Christopher I. , Schwab Frank , Bess Shay , Kim Han Jo , Lafage Virginie , Passias Peter G. 
Published: June 2023

OBJECTIVE
The objective of this study was to calibrate an updated predictive model incorporating novel clinical, radiographic, and prophylactic measures to assess the risk of proximal junctional kyphosis (PJK) and failure (PJF).

METHODS
Operative patients with adult spinal deformity (ASD) and baseline and 2-year postoperative data were included. PJK was defined as ≥ 10° in sagittal Cobb angle between the inferior uppermost instrumented vertebra (UIV) endplate and superior endplate of the UIV + 2 vertebrae. PJF was radiographically defined as a proximal junctional sagittal Cobb angle ≥ 15° with the presence of structural failure and/or mechanical instability, or PJK with reoperation. Backstep conditional binary supervised learning models assessed baseline demographic, clinical, and surgical information to predict the occurrence of PJK and PJF. Internal cross validation of the model was performed via a 70%/30% cohort split. Conditional inference tree analysis determined thresholds at an alpha level of 0.05.

RESULTS
Seven hundred seventy-nine patients with ASD (mean 59.87 ± 14.24 years, 78% female, mean BMI 27.78 ± 6.02 kg/m2, mean Charlson Comorbidity Index 1.74 ± 1.71) were included. PJK developed in 50.2% of patients, and 10.5% developed PJF by their last recorded visit. The six most significant demographic, radiographic, surgical, and postoperative predictors of PJK/PJF were baseline age ≥ 74 years, baseline sagittal age-adjusted score (SAAS) T1 pelvic angle modifier > 1, baseline SAAS pelvic tilt modifier > 0, levels fused > 10, nonuse of prophylaxis measures, and 6-week SAAS pelvic incidence minus lumbar lordosis modifier > 1 (all p < 0.015). Overall, the model was deemed significant (p < 0.001), and internally validated receiver operating characteristic analysis returned an area under the curve of 0.923, indicating robust model fit.

CONCLUSIONS
PJK and PJF remain critical concerns in ASD surgery, and efforts to reduce the occurrence of PJK and PJF have resulted in the development of novel prophylactic techniques and enhanced clinical and radiographic selection criteria. This study demonstrates a validated model incorporating such techniques that may allow for the prediction of clinically significant PJK and PJF, and thus assist in optimizing patient selection, enhancing intraoperative decision making, and reducing postoperative complications in ASD surgery.
Outcomes and reoperation rates of adult spinal deformity patients with baseline sagittal malalignment based on the cranial axis to the hip at 2 years postoperatively
Authors: Mohanty Sarthak , Lai Christopher , Mikhail Christopher , Greisberg Gabriella , Hassan Fthimnir M. , Stephan Stephen R. , Sardar Zeeshan M. , Lehman Ronald A. , Lenke Lawrence G. 
Published: June 2023

OBJECTIVE
The aim of this study was to discern whether patients with a cranial sagittal vertical axis to the hip (CrSVA-H) > 2 cm at 2 years postoperatively exhibit significantly worse patient-reported outcomes (PROs) and clinical outcomes compared with patients with CrSVA-H < 2 cm.

METHODS
This was a retrospective, 1:1 propensity score–matched (PSM) study of patients who underwent posterior spinal fusion for adult spinal deformity. All patients had a baseline sagittal imbalance of CrSVA-H > 30 mm. Two-year patient-reported and clinical outcomes were assessed in unmatched and PSM cohorts, including Scoliosis Research Society–22r (SRS-22r) and Oswestry Disability Index scores as well as reoperation rates. The study compared two cohorts based on 2-year alignment: CrSVA-H < 20 mm (aligned cohort) vs CrSVA-H > 20 mm (malaligned cohort). For the matched cohorts, binary outcome comparisons were carried out using the McNemar test, while continuous outcomes used the Wilcoxon rank-sum test. For unmatched cohorts, categorical variables were compared using chi-square/Fisher’s tests, while continuous outcomes were compared using Welch’s t-test.

RESULTS
A total of 156 patients with mean age of 63.7 (SEM 1.09) years underwent posterior spinal fusion spanning a mean of 13.5 (0.32) levels. At baseline, the mean pelvic incidence minus lumbar lordosis mismatch was 19.1° (2.01°), the T1 pelvic angle was 26.6° (1.20°), and the CrSVA-H was 74.9 (4.33) mm. The mean CrSVA-H improved from 74.9 mm to 29.2 mm (p < 0.0001). At the 2-year follow-up, 129 (78%) of 164 patients achieved CrSVA-H < 2 cm (aligned cohort). Patients who had CrSVA-H > 2 cm (malaligned cohort) at the 2-year follow-up had worse preoperative CrSVA-H (p < 0.0001). After performing PSM, 27 matched pairs were generated. In the PSM cohort, the aligned and malaligned cohorts demonstrated comparable preoperative patient-reported outcomes (PROs). However, at the 2-year postoperative follow-up, the malaligned cohort reported worse outcomes in SRS-22r function (p = 0.0275), pain (p = 0.0012), and mean total score (p = 0.0109). Moreover, when patients were stratified based on their magnitude of improvement in CrSVA-H (< 50% vs > 50%), patients with > 50% improvement in CrSVA-H had superior outcomes in SRS-22r function (p = 0.0336), pain (p = 0.0446), and mean total score (p = 0.0416). Finally, patients in the malaligned cohort had a higher 2-year reoperation rate (22% vs 7%; p = 0.0412) compared with patients in the aligned cohort.

CONCLUSIONS
Among patients who present with forward sagittal imbalance (CrSVA-H > 30 mm), patients with CrSVA-H exceeding 20 mm at the 2-year postoperative follow-up have inferior PROs and higher reoperation rates.
PENURUNAN NILAI pH, COD, TDS, TSS PADA AIR SUNGAI MENGGUNAKAN LIMBAH KULIT JAGUNG MELALUI ADSORBEN
Authors: Pratiwi Indah , Indah Agustiorini  
Published: June 2023

Selain gandum dan padi, jagung (zea mays) adalah salah satu tanaman pangan yang memiliki kandungan karbohidrat. Kulit jagung dan tongkol jagung merupakan limbah padat dari hasil pengolahan jagung. Peningkatan nilai ekonomis dari kulit jagung yaitu dengan manfaatkan kulit jagung tersebut sebagai adsorben. Pada kulit jagung terdapat kandungan selulosa 41% dan hemiselulosa 36%. Pada Penelitian ini bertujuan untuk mengetahui proses pembuatan adsorben berjenis karbon aktif dan efektifitas karbon aktif kulit jagung untuk mengelola air sungai terhadap kadar COD, TSS, dan TDS. Tiga proses utama dalam pembuatan karbon aktif ini yaitu proses dehidrasi, karbonisasi, dan aktivasi. Aktivasi karbon aktif menggunakan H2O2 1 M, dengan kondisi operasi 500°C durasi 30 menit. Karbon aktif kemudian diuji dengan sample air sungai menggunakan variasi sebanyak 0 g; 1 g; 2 g ;3 g; 4 g; 5 g dan waktu kontak perendaman 24 jam. Variasi massa karbon aktif 4 gr merupakan hasil optimal yang didapatkan. Penurunan yang mampu dihasilkan dari pengujian air sungai tersebut adalah COD sebesar 12,8 mg/l ; TSS 10 mg/l ; TDS 120 mg/l daripada tanpa menggunakan adsorben COD sebesar 25,6 mg/l ; TSS 19 mg/l ; TDS 200 mg/l . Karbon aktif yang dibuat dari kulit jagung ini efektif digunakan pada pengolahan air sungai dibuktikan dengan adanya penurunan nilai COD,TSS dan TDS.
ENKRIPSI SMS DENGAN MENGGUNAKAN MODE CIPHER FEEDBACK (CFB) 8-BIT BERBASIS ANDROID
Authors: Widiana Siska Ayu , Iqbal Firdaus  
Published: June 2023

Tujuan dari penelitian ini adalah untuk mengurangi faktor-faktor yang mengancam keamanan isi pesan dengan menggunakan aplikasi enkripsi SMS dengan menggunakan mode cipher feedback 8-bit pada aplikasi android. Faktor pertama, yaitu faktor fisik adalah jika telepon selular dipegang oleh orang lain maka orang tersebut dapat membaca dan mendapatkan informasi dari pesan di dalam telepon selular. Faktor kedua adalah keamanan pesan di dalam sistem, penyebabnya karena operator selular hanya mengenkripsi pesan pada saat proses transmisi, sedangkan dalam proses penyimpanan pesan di operator selular berbentuk plainteks. Tahapan proses pada mode cipher feedback 8-bit dimulai dengan menginput SMS yang akan dikirimkan, yaitu berupa plainteks dan ditambah dengan menginput initialization vector (IV) dan kunci yang di proses melalui fungsi enkripsi menggunakan algoritma AES 128 untuk menghasilkan keystream. 8 bit awal hasil dari keystream ini lalu di exclusive or (XOR) kan dengan 8 bit awal plainteks dan hasil yang didapat akan dikembalikan lagi ke blok paling kiri dari IV awal dengan proses register geser, dan begitu pun selanjutnya sampai dihasilkan sebuah pesan yang berbentuk cipherteks yang berbentuk deretan heksadesimal. Hasil cipherteks tersebut lah yang akan dikirimkan kepada penerima pesan melalui server sehingga pesan asli yang ditujukan kepada penerima dapat dijaga kerahasiaannya. Sesuai dengan hasil diatas maka dapat disimpulkan bahwa isi pesan yang dikirimkan tidak akan bisa dibaca kecuali oleh pengirim dan penerima saja.
Aplikasi Mikoriza dan Rock Phosphate terhadap Pertumbuhan, Hasil, dan Kualitas Jagung Ketan
Authors: Suhartanti Anik , Oktavia Sarhesti Padmini  , Muhammad Husain Kasim  
Published: June 2023

Pengguanan pupuk hayati mikoriza dan batuan fosfat (rock phosphate) dalam memacu pertumbuhan tanaman jagung telah banyak dikembangkan. Penelitian ini bertujuan untuk meningkatkan pertumbuhan dan hasil tanaman jagung dengan mengkombinasikan antara penggunaan mikoriza dan rock phosphate. Penelitian dilakukan selama 3 bulan di Dusun Sengir, Sumberharjo, Prambanan. Penelitian dilakukan dengan metode eksperimen di lapangan dengan menggunakan rancangan acak kelompok (RAK) faktorial yang terdiri dari 2 faktor perlakuan. Faktor pertama yaitu dosis pupuk hayati mikoriza yang terdiri dari 3 level yaitu tanpa mikoriza, mikoriza 5 g/tanaman, dan mikoriza 10 g/tanaman. Faktor kedua yaitu berbagai dosis pupuk rock phosphate yang terdiri dari 4 level yaituÂ tanpa rock phosphate, rock phosphate 100 kg/ha (1,75 g/tan), 200kg/ha (3,50 g/tan), dan 300 kg/ha (5,25 g/tan). Data hasil pengamatan dianalisis menggunakan uji Anova dan uji lanjut DMRT dengan tarafÂ 5%. Hasil penelitian menunjukkan bahwa Terdapat pengaruh mandiri pemberian Mikoriza pada tinggi tanaman, diameter batang, bobot tongkol, panjang tongkol, dan diameter tongkol, dengan hasil terbaik pada dosis 10g/tan. Sementara itu, pengaruh mandiri rock phosphate terdapat pada parameter jumlah daun, diameter batang, bobot tongkol, panjang tongkol, dan diameter tongkol, dengan hasil terbaik pada dosis 300kg/ha.
EKSPLORASI NEMATODA SISTA KENTANG (Globodera rostochiensis) PADA LAHAN TANAMAN KENTANG DI DESA SUMBER BRANTAS JAWA TIMUR
Authors: Noni Rahmadhini  , Okta Gegana Purwadi  , Wiludjeng Widayati  
Published: June 2023

Kentang merupakan salah satu komoditas penting dan mendapat prioritas untuk dikembangkan di Indonesia karena potensi ekspor yang tinggi ke negara lain. Salah satu hambatan dalam peningkatan produksi tanaman kentang yaitu adanya serangan nematoda sista kentang (NSK). Penelitian ini bertujuan untuk mengetahui keberadaan NSK pada lahan kentang di Desa Sumber Brantas, Kecamatan Bumi Aji, Kota Batu, Provinsi Jawa Timur. Penelitian ini dilakukan dengan cara survei yaitu pengambilan sampel tanah di 2 lahan pertanaman kentang dan mengidentifikasi nematoda yang terdapat di dalamnya. Proses identifikasi dilakukan di Laboratorium Balai Besar Karantina Pertanian, Surabaya. Penelitian dilaksanakan pada bulan April hingga Mei 2022. Identifikasi dilakukan melalui pendekatan morfologi pada karakter pola perineal/sidik pantat nematoda betina. Hasil penelitian menunjukkan bahwa pada lokasi penelitian telah ditemukan sebanyak 1528 sista yang berasal dari spesies Globodera rostochiensis.
Potato is one of the important commodities and has priority to be developed in Indonesia because of its high export potential to other countries. One of the obstacles in increasing the production of potato plants is the potato cyst nematode (NSK) attack. This study aims to determine the presence of NSK on potato fields in Sumber Brantas Village, Bumi Aji District, Batu City, East Java Province. This research was conducted by means of a survey, namely taking soil samples in 2 potato plantations and identifying the nematodes present in them. The assistance process was carried out at the Laboratory of the Agricultural Quarantine Center, Surabaya. The study was conducted from April to May 2022. Identification was carried out through a morphological approach to the perineal pattern/butt print of female nematodes. The results showed that 1528 cysts from the Globodera rostochiensis species were found at the study site
THE EFFECT OF VARIATION OF WELDING CURRENT ON 6061 ALUMINUM PIPE ON MECHANICAL PROPERTIES AND MICRO STRUCTURE USING TIG WELDIN
Authors: Santosa Aa , Noubnome Viktor , Candra Muhkti Maulana 
Published: June 2023

Abstract
TIG welding is a welding technique for connecting metals using tungsten rod electrodes and using noble gas as a protective gas which is exhaled on the weld metal to protect against contamination with the surrounding atmosphere. Aluminum metal is a metal that has a high affinity for absorbing H2, N2 and O2 in the air at high temperatures, so it is necessary to have a high purity protective gas during the welding process, because N2 H2 and O2 will cause a decrease in the corrosion resistance of the material. To find out the effect of the TIG welding process on the mechanical properties and microstructure, a study was carried out to determine the mechanical properties, namely hardness, and bending properties, as well as the microstructure found in aluminum after the tungsten inert gas welding process was carried out using current. different. In this study the welding process used the Tungsten Innert Gas process by varying the welding current, namely 100 A, 130 A and with a welding time of 2.5 seconds, 4.5 seconds, . So that from the welding parameters used, it will be known the effect of the welding parameters

Keywords : Welding Current, Alumnium Metal, TIG welding