bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teologi Islam Moderat Berbasis Intellectual Humility Kiai Sholeh Bahruddin: Perspektif Psikologi Positif
Authors: Zuhri Achmad Muhibin 
Published: September 2023

This study explores moderate Islamic theology with a focus on applying the concept of intellectual humility by Kiai Haji Sholeh Bahruddin. Intellectual humility is a humble attitude that acknowledges human knowledge's limitations. The purpose of this study is to explore how the principle of intellectual humility can influence Kiai Haji Sholeh Bahruddin's view of religion and society, as well as its positive impact from a positive psychology perspective. The research method used is a qualitative approach with a phenomenological approach. Data were obtained through in-depth interviews with Kiai Haji Sholeh Bahruddin, as well as analysis of documents related to his views on moderate Islamic theology. Data analysis was carried out in the following steps: first, identifying the beliefs and values of moderate Islamic theology as applied by Kiai Haji Sholeh Bahruddin; second, describing how intellectual humility is reflected in the approach and views of Kiai Haji Sholeh Bahruddin; third, analyze the positive impact of the application of intellectual humility in forming an inter-religious dialogue, tolerance, and harmonious relations in society. The results of this study reveal that Kiai Haji Sholeh Bahruddin applies intellectual humility in his interpretation and communication of Islamic teachings, which opens up space for more open interreligious dialogue and acceptance of different views. This research aims to support the importance of a moderate approach to religion and show that intellectual humility can be an important instrument in building an inclusive and harmonious society.
The Use of CD200 in the Differential Diagnosis of B-Cell Lymphoproliferative Disorders
Authors: Al-Zubaidi Hanaan Kareem , Hughes Stephen Fôn 
Published: September 2023

Background: B-Cell Lymphoproliferative Disorders (B-LPDs) are a group of heterogenous disorders characterised by the accumulation of B-cells in peripheral blood, bone marrow, lymph nodes and spleen. They have a variable disease course and outcome and many share similar features making differential diagnosis challenging. Therefore, accurate diagnosis is fundamental in particular for determining treatment options. Immunophenotyping by flow cytometry plays a crucial role in the diagnosis of B-LPDs. However, overlapping immunophenotyping patterns exist and the use of novel monoclonal antibodies has become increasingly important in immunophenotyping analysis. More recently differential expression of CD200 has been reported in various B-LPDs and that CD200 may improve the differentiation between chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL). In this study CD200 expression is evaluated in different B-LPDs.Methods: A total of 100 samples were collected and analysed by immunophenotyping flow cytometry over a period of 1 year (2017–2018), by a panel of monoclonal antibodies including CD200. The percentage of CD200 and its expression intensity was evaluated and compared between different groups of B-LPDs.Results: All of the 50 cases of CLL expressed CD200 with moderate to bright intensity, 6 MCL cases lacked the expression of CD200. Furthermore, all 5 cases of hairy cell leukaemia (HCL) expressed CD200. Out of all B-LPDs evaluated, CD200 expression in HCL cases was noted to be the brightest. The other 39 cases were not found to be B-LPDs.Conclusion: CD200 has an important role in differentiating CLL from MCL, HCL has a consistent bright expression of CD200. By adding CD200 to the combinations of markers in routine testing panel, Immunophenotyping by flow cytometry can be an effective tool in the diagnosis of B-LPDs especially in cases with atypical immunophenotyping pattern. Our result support that CD200 can be added to routine testing panel as it is useful in differentiating them.
Synthesis, in silico and in vitro antimicrobial efficacy of substituted arylidene-based quinazolin-4(3H)-one motifs
Authors: Oduselu Gbolahan O. , Aderohunmu Damilola V. , Ajani Olayinka O. , Elebiju Oluwadunni F. , Ogunnupebi Temitope A. , Adebiyi Ezekiel 
Published: September 2023

Introduction: Quinazolin-4(3H)-one derivatives have attracted considerable attention in the pharmacological profiling of therapeutic drug targets. The present article reveals the development of arylidene-based quinazolin-4(3H)-one motifs as potential antimicrobial drug candidates.Methods: The synthetic pathway was initiated through thermal cyclization of acetic anhydride on anthranilic acid to produce 2-methyl-4H-3,1-benzoxazan-4-one 1, which (upon condensation with hydrazine hydrate) gave 3-amino-2-methylquinazolin-4(3H)-one 2. The reaction of intermediate 2 at its amino side arm with various benzaldehyde derivatives furnished the final products, in the form of substituted benzylidene-based quinazolin-4(3H)-one motifs 3a–l, and with thiophene-2-carbaldehyde to afford 3 m. The purified targeted products 3a–m were effectively characterized for structural authentication using physicochemical parameters, microanalytical data, and spectroscopic methods, including IR, UV, and 1H- and 13C-NMR, as well as mass spectral data. The substituted arylidene-based quinazolin-4(3H)-one motifs 3a–m were screened for both in silico and in vitro antimicrobial properties against selected bacteria and fungi. The in silico studies carried out consisted of predicted ADMET screening, molecular docking, and molecular dynamics (MD) simulation studies. Furthermore, in vitro experimental validation was performed using the agar diffusion method, and the standard antibacterial and antifungal drugs used were gentamicin and ketoconazole, respectively.Results and discussion: Most of the compounds possessed good binding affinities according to the molecular docking studies, while MD simulation revealed their levels of structural stability in the protein–ligand complexes. 2-methyl-3-((thiophen-2-ylmethylene)amino) quinazolin-4(3H)-one 3 m emerged as both the most active antibacterial agent (with an minimum inhibitory concentration (MIC) value of 1.95 μg/mL) against Staphylococcus aureus and the most active antifungal agent (with an MIC value of 3.90 μg/mL) against Candida albicans, Aspergillus niger, and Rhizopus nigricans.
Enhanced recovery in patients with gestational diabetes mellitus and MTHFR 677 TT genotype after taking high-dose folic acid supplements during mid-late pregnancy: an open-label interventional study
Authors: Ying Jun , Zhang Jie , Li Piyu , Liu Lu , Li Yan , Lau Winnie W.Y. , Chu Qiao , Wu Benqing , Wang Xiaonan , Zhang Hui 
Published: September 2023

ObjectiveTo explore the relationship between folic acid supplementation and the recovery rate of gestational diabetes mellitus (GDM) in women with methylenetetrahydrofolate (MTHFR) 677 TT genotypes in mid-late pregnancy.Methods9, 096 pregnant women were recruited with their MTHFR gene genotyped. 5,111 women underwent a 75-g oral glucose tolerance test (OGTT) and 2,097 were confirmed with GDM. The association between MTHFR genotypes and GDM risk was estimated using logistic and log-binomial regression, with age and parity set as the covariates to control their confounding effects. Further assessment of GDM risk on glucose levels was done using the ANCOVA model. As an open-label intervention study, 53 GDM patients with TT genotype were prescribed 800μg/day of folic acid as the high-dose group, while 201 GDM patients were given 400μg/day as the standard-dose group at their 24-28 weeks of pregnancy. A rate ratio (RR) of GDM recovery was estimated at each available time point for both groups. The time-to-GDM persistence events were analyzed with the Kaplan-Meier method and Cox-regression model. The trend of glucose levels over time was estimated using the linear model.ResultsMTHFR 677 TT genotype has no significant association with the glucose levels and GDM risk, with an adjusted OR of 1.105 (95% CI 0.853, 1.431; p=0.452) and an adjusted PR of 1.050 (95% CI 0.906, 1.216; p=0.518) compared to the wildtype CC group. Patients in the high-dose group (n=38; 15 drop-outs; 40.69 days (95% CI 33.22, 48.15)) recovered from GDM approximately 27 days faster than those in the standard-dose group (n=133; 68 drop-outs; 68.09 days (95% CI 63.08, 73.11)). Concomitantly, the RR of GDM recovery rose and reached 1.247 (95% CI 1.026, 1.515) at 100 days of treatment with the standard-dose group as reference.ConclusionHigh-dose folic acid supplement intake in mid-late pregnancy is associated with faster GDM relief in patients with MTHFR 677 TT genotype compared to the standard dose, which would be served as a novel and low-cost alternative therapy for the treatment of GDM.
Statin treatment is not associated with an increased risk of adrenal insufficiency in real-world setting
Authors: Maumus-Robert Sandy , Jarne-Munoz Ana , Pariente Antoine , Duroux Thomas , Duranteau Lise , Bezin Julien 
Published: September 2023

IntroductionStatins could reduce the synthesis of steroid hormones, thereby could cause adrenal insufficiency. We investigated this risk in a large nationwide database.MethodsWe conducted a nested case-control study using a cohort of individuals affiliated to the French health insurance system in 2010, ≥18y and without adrenal insufficiency history. Each case had a first event of adrenal insufficiency between 2015 and 2017 and was matched to up to ten controls on age, sex, and prior treatment with corticosteroids. Statin exposure was measured over the five years preceding the index date, considering a six-month censoring lag-time. Association was estimated using a conditional logistic regression adjusted for confounders included in a disease risk score. Analyses were stratified on age, sex and corticosteroid history of use.Results4 492 cases of adrenal insufficiency were compared with 44 798 controls (median age 66y, 58% women), of which 39% vs. 33% were exposed to statins, respectively. No association between statin use and adrenal insufficiency was found when adjusting the model for confounders (adjusted odds ratio 0.98; 95% confidence interval 0.90-1.05). These results were consistent regardless of the exposure definition and stratifications considered.ConclusionStatin-related adrenal insufficiency risk, if any, seems to be very limited and does not compromise the benefit of statin treatment.
Low carbon and environmental preservation of residential buildings: MOESOM
Authors: Liang Nan , Yu Mengxuan 
Published: September 2023

Introduction: The crucial transition toward carbon neutrality is developing and adopting low-carbon buildings and communities to achieve the recycling and reuse of resources and to minimize the damage to the natural environment by humans. Energy saving for residential buildings is essential for enhancing cost-effectiveness and redundant energy drain. Considering the increasing attention to energy conservation and the accessibility of sustainable energy sources, common energy-saving solutions expose inherent inadequacies limiting their effectiveness. The ineffectual use of traditional energy sources can result in waste, greater operating costs, and excessive energy consumption in residential structures.Methods: Hence, a Multi-Objective Energy-Saving Optimization Method (MOESOM) has been proposed to optimize energy use and conservation in residential buildings in southern Anhui, China. The proposed approach examines lower operational costs and carbon emissions by using green energy sources and encouraging effective energy consumption habits. The suggested Multi-Objective Energy-Saving Optimization Method technique offers insight into energy saving by utilizing green energy sources and confining energy uses. The multi-objective turns around energy saving and resource usage for decreasing operational costs and averting carbon emissions. Thus, the suggested technique is verified utilizing the Osprey Optimization Algorithm (OOA); the detailed goal is recognized utilizing the multiple objectives described. Based on the progress of low-carbon emissions and energy saving, the number of iterations for augmenting Osprey agents is identified. This agent-based optimization is executed if the novel augmented agent fulfills any of the trailing progression. The emission control level and energy-saving factor are assessed considering the variance between new and old agent progression. This encourages the various objectives to be fulfilled under similar criteria balancing their outcomes.Results and discussion: The output from different Osprey agents is induced for consecutive objectives and optimization factors. Then, the system ensures 8.97% energy savings and 8.04% high objectives compared to the other methods.
Study on human-SRL synchronized walking based on coupled impedance
Authors: Liu Zihao , Xiang Kui , He Wutong , Gao Xiang , Peng Yaling , Pang Muye 
Published: September 2023

IntroductionSupernumerary robotic limbs (SRL) is a novel category of wearable robotics. Unlike prostheses (compensation for human limbs) and exoskeletons (augmentation of human limbs), SRL focuses on expanding human limbs and enhancing human activities, perception, and operation through the mutual collaboration of mechanical limbs and human limbs. The SRL of lower limbs are attached to the human waist, synchronized with the human walking in the forward direction, and can carry weight independently in the vertical direction.MethodsIn order to enhance the synchronization performance of the human-machine system during walking and minimize interference with human gait, it is essential to investigate the coupling dynamics within the human-SRL system. To facilitate our research, this paper focuses on relatively ideal working conditions: level road surfaces, no additional weight-bearing on the SRL, and humans walking in a straight line without any turns. We build upon the passive dynamic walking theory and utilize the human-SRL system model established by MIT to develop a coupling system model. Through numerical simulations, we identify the optimal values for the stiffness and damping coefficients of the human-machine connection. Additionally, we have designed the wheel-legged SRL structure and constructed the SRL control system for experimental validation.ResultsIt is found that a better synchronization of the human-machine walking process can be achieved by configuring suitable spring and damping units in the human-machine connection part.DiscussionIn this study, we explored the concept of SRL and its potential benefits for enhancing human motion, conducting simulations and experiments based on the coupled dynamics of human-SRL systems. The results indicate that by equipping the human-machine connection component with suitable spring and damping units, synchronization during the walking process can be improved.
Effectiveness of orange almond potato cookie vs. orange potato cookie supplementation on nutritional wellbeing of the Indonesian stunted preschool-aged children during COVID-19 pandemic
Authors: Fatmah Fatmah , Utomo Suyud W. 
Published: September 2023

BackgroundPreschool-aged children who experience stunting due to insufficient consumption of macro- and micronutrients exhibit weakened immune systems, rendering them susceptible to contracting COVID-19 during the ongoing epidemic. Therefore, it is imperative to implement interventions aimed at enhancing the nutritional status of preschool-aged children by providing them with nutrient-rich food supplements as a preventive measure against illness transmission. The objective of the study was to evaluate the impact of incorporating potato almond orange cookies into the diet on the nutritional status of preschool-aged children who are experiencing stunting.MethodsA non-randomized pre-post intervention study was done on 42 individuals aged 12–58 months during 4 weeks. The intervention group was provided with almond potato cookies, while the control group was given orange potato cookies. During the study period, educational sessions on balanced nutrition in preschool-aged children with stunting and COVID-19 were provided to the mothers of both groups. The data analysis involved conducting univariate and bivariate analyses, namely utilizing the independent t-test.ResultsThe intervention group exhibited the most significant enhancements in -for-Age Z-score. The mean -for-Age Z-score of the intervention group increased by 0.51 (from −3.15 to −2.64), whereas the control group saw a smaller gain of 0.25 (from −2.69 to −2.44). This increase was influenced by the mother’s age; mother’s education; father’s occupation; family size; good sanitation facilities; healthy home environment; and fat, calcium, and zinc intake from the cookies (p &lt; 0.05). From the perspective of knowledge about balanced nutrition and COVID-19, there was no significant difference in the -for-Age Z-score in the intervention group.ConclusionThe ingestion of orange almond potato cookies has the potential to enhance the nutritional wellbeing of children in the preschool age group who are experiencing stunted growth.
Treating acute exacerbations of COPD with Chinese herbal medicine to aid antibiotic use reduction (Excalibur): a randomised double-blind, placebo-controlled feasibility trial
Authors: Willcox Merlin L. , Hu Xiao-Yang , Oliver Tom , Thorne Kerensa , Boxall Cherish , He George , Simpson Catherine , Brotherwood Becci , O’Neil Alice , Waugh Robert , Tilt Emma , Trill Jeanne , Goward Neville , Francis Nick , Thomas Michael , Little Paul , Wilkinson Tom , Liu Jian-Ping , Griffiths Gareth , Moore Michael 
Published: September 2023

Background: Although many acute exacerbations of COPD (AECOPD) are triggered by non-bacterial causes, they are often treated with antibiotics. Preliminary research suggests that the Chinese herbal medicine “Shufeng Jiedu” (SFJD), may improve recovery and therefore reduce antibiotic use in patients with AECOPD.Aims: To assess the feasibility of conducting a randomised placebo-controlled clinical trial of SFJD for AECOPD in UK primary care.Methods: GPs opportunistically recruited patients experiencing an AECOPD. Participants were randomised 1:1 to usual care plus SFJD or placebo for 14 days. Participants, GPs and research nurses were blinded to treatment allocation. GPs could prescribe immediate, delayed or no antibiotics, with delayed prescribing encouraged where appropriate. Participants were asked to complete a participant diary, including EXACT-PRO and CAT™ questionnaires for up to 4 weeks. Outcomes included recruitment rate and other measures of study feasibility described using only descriptive statistics and with no formal comparisons between groups. We also conducted qualitative interviews with recruited and non-recruited COPD patients and clinicians, analysed using framework analysis.Results: Over 6 months, 19 participants (6 SFJD, 13 placebo) were recruited. Sixteen (84%) participants returned diaries or provided a diary by recall. Overall, 1.3 participants were recruited per 1,000 patients on the COPD register per month open. Median duration of treatment was 9.8 days in the intervention group vs 13.3 days in the placebo group. The main reason for discontinuation in both groups was perceived side-effects. in both groups. Point estimates for both the EXACT-PRO and CAT™ outcomes suggested possible small benefits of SFJD. Most patients and clinicians were happy to try SFJD as an alternative to antibiotics for AECOPD. Recruitment was lower than expected because of the short recruitment period, the lower incidence of AECOPD during the COVID-19 pandemic, patients starting antibiotics from “rescue packs” before seeing their GP, and workforce challenges in primary care.Conclusion: Recruitment was impaired by the COVID-19 pandemic. Nevertheless, we were able to demonstrate the feasibility of recruiting and randomising participants and identified approaches to address recruitment challenges such as including the trial medication in COPD patients’ “rescue packs” and delegating recruitment to a central trials team.Clinical Trial Registration: Identifier, ISRCTN26614726
A disulfidptosis-related lncRNA prognostic model to predict survival and response to immunotherapy in lung adenocarcinoma
Authors: Zhang Hai-Bo , Pan Jian-Yan , Zhu Tao 
Published: September 2023

Background: Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and has a poor prognosis. Disulfidptosis is a novel regulated cell death form characterized by aberrant disulfide stress and actin network collapse. This study aimed to identify disulfidptosis-related lncRNAs, and predict LUAD patients’ prognosis and response to antitumor therapies by establishing a disulfidptosis-related lncRNA model.Methods: Transcriptome and clinical data of LUAD patients were obtained from the TCGA database. Pearson correlation and Cox regression analysis was used to identify disulfidptosis-related lncRNAs associated with overall survival. LASSO regression analysis was adopted to construct the prognostic model. GO, KEGG and GSEA analysis was used to identify cellular pathways related to this model. Immune cell infiltration was investigated by ESTIMATE and CIBERSORT algorithms. Tumor mutational burden (TMB) and its association with model-derived risk score were analyzed using simple nucleotide variation data. Patients’ response to immunotherapy and other antineoplastic drugs was predicted by the TIDE algorithm and GDSC tool, respectively.Results: We identified 127 disulfidptosis-related lncRNAs, and a prognostic model that consists eight of them (KTN1-AS1, AL365181.3, MANCR, LINC01352, AC090559.1, AC093673.1, AP001094.3, and MHENCR) was established and verified. The prognostic model could stratify LUAD patients into two distinct risk-score groups. A high risk score was an independent prognosis factor indicating poor overall survival, and correlated with reduced immune cell infiltration, high TMB, and lower activity of tumor immune response. Immune checkpoint blockade might bring more survival benefits to the high-risk LUAD patients, whereas low-risk patients might be more responsive to targeted therapy and diverse kinase inhibitors.Conclusion: We established a disulfidptosis-related lncRNA model that can be exploited to predict the prognosis, tumor mutational burden, immune cell infiltration landscape, and response to immunotherapy and targeted therapy in LUAD patients.