bluuebunny/crossref_metadata_2025_split huggingface dataset:
Being forced into an unsustainable and unethical working situation while caring for older people during the COVID-19 pandemic in Sweden
Authors: Lövenmark Annica , Hammar Lena Marmstål 
Published: May 2023

Abstract
Bakground: Worldwide, older people were more severely affected during the COVID-19 pandemic than others. In Sweden, those living in residential care facilities had the highest mortality rate, followed by those receiving home care services. The Swedish and international literature on the working environment for auxiliary nurses and nursing aides during the pandemic shows an increase in stress, anxiety, depression and post-traumatic stress syndromes. Care organisations were badly prepared to prevent the virus from spreading and to protect the staff from stress. In order to be better prepared for possible future pandemics, the health and well-being of the staff, the care of older people and the experiences of the staff both during and after a pandemic are important aspects to take into account. Therefore, this study aims to describe the residential care and home care service staff’s physical and psychosocial working experiences during and after the COVID-19 pandemic in Sweden.
Methodology: The data was collected through four focus groups interviews with 19 participants and analysed using qualitative content analysis.
Results: The result shows that the staff were forced into an unsustainable and unethical working situation by being portrayed as scapegoats by the older people’s relatives and the news media. In addition, they did not feel valued by people in general or by their own managers. The worsening working conditions that the pandemic contributed to resulted in a high degree of stress and risk of burnout, with staff members both wanting to and actually leaving their employment. Not only did the staff become innocent scapegoats in terms of the spread of the virus, after the pandemic they felt forgotten again and left to cope in an even worse situation than before.
Conclusions: According to the participants, the pandemic brought them, their working conditions and this part of the caring system to a tipping point, which the government and the media should no longer ignore. The pandemic revealed even more unsustainable and unethical working conditions for the staff in HCR and RCS than before the pandemic, including the vulnerability of the older people in their care.
The Superior Colliculus Projection Upon the Macaque Inferior Olive
Authors: May Paul J. , Warren Susan , Kojima Yoshiko 
Published: May 2023

Abstract
Saccade accommodation is a productive model for exploring the role of the cerebellum in behavioral plasticity. In this model, the target is moved during the saccade, gradually inducing a change in the saccade vector as the animal adapts. The climbing fiber pathway from the inferior olive provides a visual error signal generated by the superior colliculus that is believed to be crucial for cerebellar adaptation. However, the primate tecto-olivary pathway has only been explored using large injections of the central portion of the superior colliculus. To provide a more detailed picture, we have made injections of anterograde tracers into various regions of the macaque superior colliculus. As shown previously, large central injections primarily label a dense terminal field within the C subdivision at caudal end of the contralateral medial inferior olive. Several, previously unobserved, sites of sparse terminal labeling were noted: bilaterally in the dorsal cap of Kooy and ipsilaterally in C subdivision of the medial inferior olive. Small, physiologically directed, injections into the rostral, small saccade portion of the superior colliculus produced terminal fields in the same regions of the medial inferior olive, but with decreased density. Small injections of the caudal superior colliculus, where large amplitude gaze changes are encoded, again labeled a terminal field located in the same areas. The lack of a topographic pattern within the main tecto-olivary projection suggests that either the precise vector of the visual error is not transmitted to the vermis, or that encoding of this error is via non-topographic means.
Air quality assessment based on a smart locally CO2 monitoring system with validation by a reference instrument
Authors: MBARNDOUKA Jacob Taamté , signing Vitrice ruben Folifack , Bobbo Modibo Oumar , Noubé Michaux Kountchou , Yerima Abba Hamadou , Saïdou  
Published: May 2023

Abstract
This article deals with the development and implementation of a low-cost smart air quality monitoring device. The study aims to develop a simple, efficient, and cheap device dedicated to real-time monitoring of carbon dioxide (CO2) concentration and atmospheric parameters such as temperature (T) and relative humidity (RH). The realized device consists of sensors, data storage system, programmable card, and IoT wireless modules. It is designed for indoor and outdoor air quality monitoring. Wireless communication between realized device and control PC is ensured by the ZigBee protocol. This investigation is carried out to assess air quality considering the proliferation of pollutants and the modification of normal concentrations of atmospheric CO2 (400 ppm). Thus, the data processed are outdoor concentrations collected in November 2022 in some localities of the Adamawa Region, Cameroon. The average values of CO2 concentration measured in four subdivisions are 497.30 ± 11.32 ppm with a maximum and minimum values of [618 ~ 443] ppm in Ngaoundéré 1, 481.83 ± 14.90 ppm with [640 ~ 453] ppm in Ngaoundéré 2, 568.63 ± 25.03 ppm with [663 ~ 223] ppm in Martap and, 624.14 ± 3.96 ppm with [661 ~ 608] ppm in Minim. Martap and Minim locate one of the top bauxite deposits in the world. These values of CO2 higher than the normal atmospheric concentration indicate a moderate Air Quality Index (AQI) in these cities during the measurement period. The designed device is inexpensive, reliable, and appropriate for air quality monitoring.
Prevalence of Malaria and COVID-19 Coinfection: A Systematic Review and Meta-Analysis
Authors: León-Figueroa Darwin A. , Barboza Joshuan J. , Aguirre-Milachay Edwin , Valladares-Garrido Mario J. , Sah Ranjit , Adhikari Suraj , Sah Sanjit , Rodriguez-Morales Alfonso J. 
Published: May 2023

Abstract
Background
COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has significantly impacted public health worldwide. However, the outcomes can be unfavourable for those living in areas where malaria is endemic and are affected by SARS-CoV-2. Therefore, this systematic review and meta-analysis aimed to determine the prevalence of coinfection between malaria and COVID-19.
Methods
A systematic review and meta-analysis of the literature were conducted, utilizing the most important databases in the field, such as PubMed, Scopus, Web of Science, Embase, and Google Scholar, up to April 9, 2023, using the search terms "Malaria" and "COVID-19". Three authors independently carried out the selection of studies, evaluation of their quality, and data extraction. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument was used to assess the quality of the studies. In addition, heterogeneity was evaluated using the statistical test I2, and the statistical analysis was performed using the R version 4.2.3 program.
Results
A total of 10227 studies were retrieved, of which 13 were included in the final meta-analysis. The pooled prevalence of coinfection between Malaria and COVID-19 was 45% (95% CI: 16, 76). Subgroup analysis was performed based on country, and the prevalence of coinfection between Malaria and COVID-19 was highest in China (100%, 95% CI: 88, 100) and lowest in the Democratic Republic of Congo (1%, 95% CI: 0, 2). Regarding the subgroup analysis to evaluate the prevalence of different types of Plasmodium spp. in COVID-19 patients, it was found that the combined prevalence of Plasmodium spp. was 53% (95% CI: 15%-88%; 478/1011 cases).
Conclusion
The current research revealed a 45% prevalence of coinfection between Malaria and COVID-19. However, additional future studies are necessary to evaluate the impact of COVID-19 in Malaria-endemic areas fully.
Trial registration
The protocol for this systematic review and meta-analysis was registered with PROSPERO under the registration number CRD42023410177.
Tripartite Real-time Semantic Segmentation Network with Scene Commonality
Authors: Wang Chenyang , Wang Chuanxu , Liu Peng , Zhang Zhe , Lin Guocheng 
Published: May 2023

Abstract
The two-branch real-time semantic segmentation network can quickly acquire low-level details and high-level semantics. However, the large contextual gap between them results in adverse impact on their fusion, and limits the further improvement of real-time segmentation accuracy. This paper proposes a Tripartite Real-time Semantic Segmentation Network with Scene Commonality (TriSCNet) to address this problem. Firstly, we add a parallel Scene Commonality Branch (SCB) based on the current two-branch architecture to learn intrinsic common features in similar street scene images, such as the spatial location distribution of various objects and the internal connections between them at the semantic level. Further, with the guidance of commonality, we propose an External Branch Attention Module (EBAM) to enrich and enhance the feature information of traditional two branches. Lastly, we utilize an Alignment and Selective Fusion Module (ASFM) to correct the misaligned context in the semantic branch and highlight the essential spatial information in the detailed branch. Our proposed TriSCNet achieves an excellent trade-off between accuracy and speed, yielding 79.6% mIOU at 67.2 FPS on Cityscapes test set and 76.8% mIOU at 127.4 FPS on CamVid test set, respectively.
Detection of DENV-1, DENV-3 and DENV-4 serotypes in Ae. aegypti and Ae. albopictus, and epidemic risk in the departments of Oueme and Plateau, South-Eastern Benin
Authors: Padonou Germain Gil , Konkon Alphonse Keller , Zoungbédji David Mahouton , Salako Albert Sourou , Sovi Arthur , Oussou Olivier , Sidick Aboubakar , Ahouandjinou Juvénal , Towakinou Linda , Ossé Razaki , Baba-Moussa Lamine , Akogbeto Martin Codjo 
Published: May 2023

Abstract
Background The present study conducted in the departments of Oueme and Plateau, aims to assess the presence of the dengue virus and its different serotypes in Ae. aegypti and Ae. albopictus, as well as the epidemic risk incurred by the populations.Method Collections of adult mosquitoes using human landing catches (HLC) were carried out in six communes, three of which (Porto-Novo, Adjarra and Avrankou) in the Oueme department, and the rest (Ifangni, Kétou and Pobè) in the Plateau department. Pools of ten Aedes mosquitoes were formed, and stored at − 80°C in RNA later. RT-PCR was used to detect dengue virus, and conventional PCR for the different setotypes. Inspection of water containers and collection of Aedes larvae were performed inside and around each house in order to calculate the stegomyan indices.Results In the six communes studied, the dengue virus was present both in Ae. Aegypti, and Ae. albopictus. Combined data of the two Aedes species at the communes level, revealed infection rates ranging from 80.00% (95% CI: 61.43–92.29) to 96.67% (95% CI: 82.78–99.92). In addition, the infection rates were similar for Aedes aegypti [88.19% (95% CI: 81.27–93.24)] and Aedes albopictus 86.79% [(95% CI: 74.66–94.52)]. The three virus serotypes detected in the pools of Aedes were: DENV-1, DENV-3 and DENV-4, with a high prevalence for the first two. Whatever the communes, the values of the stegomyan indices reached the threshold that indicates the existence of the risk of an arbovirosis epidemic.Conclusion The present study revealed that three serotypes (DENV-1, DENV-3 and DENV-4) of dengue virus circulate in Aedes aegypti and Aedes albopictus in the departments of Oueme and Plateau. Moreover, the risk of transmission of arboviruses was globally high and variable from commune to commune. These information are essential for informed decision-making in the preventive control of the disease.
Large-scale identification of lysine crotonylation reveals its potential role in oral squamous cell carcinoma
Authors: Yin Xiteng , Zhang Hongbo , Wei Zheng , Wang Yufeng , Han Shengwei , Zhou Meng , Xu Wenguang , Han Wei 
Published: May 2023

Abstract
Background
Lysine crotonylation, a newly identified type of posttranslational modification, has been implicated in the regulation of various biological processes. However, its role in oral squamous cell carcinoma (OSCC) remains unknown. The study aimed to reveal the global crotonylome in OSCC under hypoxic conditions and explore the potential underlying regulatory mechanism of crotonylation in OSCC.
Methods
Liquid-chromatography fractionation, affinity enrichment of crotonylated peptides and high-resolution mass spectrometry were used to detect differential crotonylation in CAL27 cells cultured under hypoxia. The obtained data were further analyzed through bioinformatics analysis to reveal the involved biological processes and pathways of the dysregulated crotonylated proteins. A site-mutated plasmid was used to investigate the effect of crotonylation on Heat Shock Protein 90 Alpha Family Class B Member 1 (HAP90AB1) function.
Results
The large-scale of crotonylome analysis revealed 1563 crotonylated modification sites on 605 proteins in CAL27 cells under hypoxia. Bioinformatics analysis showed that histone contonylation levels decreased while up-regulated crotonylated proteins were mainly concentrated in non-histone proteins. Notably, glycolysis-related proteins were prominently up-regulated among the identified crotonylated proteins, with HSP90AB1 having the most significant changes. Further experimental results confirmed that mutating lysine 265 of HSP90AB1 into a silent arginine weakened its function in promoting glycolysis.
Conclusion
Our study mapped the crotonylation modification of proteins under hypoxia in OSCC and uncovered the biological processes and pathways of the dysregulated crotonylated proteins. Crotonylation of HSP90AB1 in hypoxic conditions may promote the glycolysis regulation ability in OSCC, providing novel insights into the regulatory mechanism of crotonylation in OSCC under hypoxia and potential therapeutic targets for OSCC treatment.
YY1: a key regulator inhibits gastric cancer ferroptosis and mediating Apatinib-resistance
Authors: Geng Zi-Han , Du Jun-Xian , Chen Yue-Da , Zhou Ping-Hong , Qin Wen-Zheng , Luo Yi-Hong 
Published: May 2023

Abstract
Background
Gastric cancer (GC) is one of the most common and lethal cancers worldwide. Apatinib, a preoperative neoadjuvant therapy, has limited efficacy in GC patients with high YY1 expression. YY1 is associated with poor prognosis, drug resistance and metastasis in GC, but its mechanisms are unclear.
Results
We observed that higher YY1 expression levels were associated with lower postoperative progression-free survival (PFS) and disease-specific survival (DSS) rates based on the TCGA analysis. Moreover, YY1 expression was found to be an independent indicator of DSS in GC patients. Additionally, YY1 expression was significantly higher in tumor tissues compared to adjacent normal tissues. Bioinformatics analysis revealed significant differentially expressed genes (DEGs), transcriptional targets, transcription factors, and co-expressed genes related to YY1. Through LASSO Cox analysis, we identified Transferrin as a potential key protein regulated by YY1, and its high expression was correlated with adverse DSS and PFS outcomes. Further analysis showed that YY1 regulated the activity of the p53 signaling pathway and ferroptosis in GC cells. The study also revealed that YY1 overexpression suppressed immune cell infiltration in GC tumors. Furthermore, the study demonstrated that YY1 overexpression inhibited GC cell ferroptosis and mediated Apatinib resistance through the p53 signaling pathway. IFN-a reverses Apatinib resistance and immune suppression in GC tissues.
Conclusions
Our findings suggest that YY1 plays a crucial role in GC progression and prognosis and may serve as a potential therapeutic target for improving patient outcomes.
In situ Observation of the Formation of MoDTC-Derived Tribofilm on a Bearing Steel with Different Surface Roughness by Using a Reflectance Spectroscopy and its Effects on Friction
Authors: Hashizume Naoya , Tokoroyama Takayuki , Umehara Noritsugu , Murashima Motoyuki , Lee Woo-Young , Zhang Ruixi , Kunisu Masahiro , Shioji Hirotaka , Oharada Kazumasa 
Published: May 2023

Abstract
In this paper, the formation of MoDTC-derived tribofilm and effects of its characteristics on friction reduction was evaluated. To consider a transition of the tribofilm during friction, in situ observation of the tribofilm was conducted by using a reflectance spectroscopy, and then thickness and composition of the tribofilm was calculated. As a result, the rough specimen (\({R}_{a}=12.7 \text{n}\text{m}\)) showed a smaller friction coefficient and kept a larger volume fraction of MoS2 compared with the smooth specimen (\({R}_{a}=2.6 \text{n}\text{m}\)). In addition, we estimated a transition of a shear strength of the tribofilm formed on both specimens by using the in situ observed composition and contact state. From the estimation, it was indicated that the shear strength of the tribofilm determined the friction properties, and the direct contact of the asperities which was notable to the rough specimen encouraged a generation of a low-shear tribofilm.
In situ FRET measurement of cellular tension with confocal laser microscopy
Authors: Wang Junfeng , Maeda Eijiro , Tsujimura Yuki , Abe Takaya , Kiyonari Hiroshi , Kitaguchi Tetsuya , Yokota Hideo , Matsumoto Takeo 
Published: May 2023

Abstract
Mechanical forces govern many cellular functions, ranging from the embryonic development to the etiology of critical diseases. This fact attracts researchers in life science to study how cells sense and respond to extrinsic mechanical loading, and how cells generate mechanical force to regulate extracellular environment. To monitor the intracellular mechanical environment, FRET-based sensors are utilized for real-time measurements of cellular tension. However, transfection of the sensor gene shows low efficacy and is only effective for a short period. Transgenic mice expressing such sensors have been developed, but sensor fluorescence has not been measured successfully using conventional confocal microscopy. Therefore, methods for spatiotemporal measurement of cellular tension in vivo or ex vivo are still limited. We established reporter mouse lines expressing FRET-based actinin tension sensors consisting of EGFP as the donor and mCherry as the acceptor. Fluorescence from sensor fluorophores and FRET signal were visualized in aorta, tendon, heart, skin, diaphragm, and intestine from young and adult reporter mice with confocal microscopy. In addition, FRET tension sensor responded well to chemical stimuli to increase or decrease intracellular tension in isolated aortic smooth muscle cells. Furthermore, application of macroscopic mechanical stretch induced tension-induced changes in FRET signals in the aorta and tail tendon fascicles, as well as aortic smooth muscle cells isolated from these mice. The pattern of FRET changes was distinctive and dependent on tissue type, reflecting differences in extracellular matrix structures and functional requirements for cells residing in these load-bearing tissues. Aortic smooth muscle cells exhibit lower sensitivity to tensile strain in situ than in an isolated state, proving for the first time that change in intracellular tension was smaller in situ than in vitro at the same macroscopic strain level. This mouse strain will enable novel types of mechanobiological and biomechanical investigations of cell functions in important physiological events.
Konzeptdialoge als Aufgabenformat in der Lehrer*innenbildung und die Reflexion ihres Potenzials für den inklusiven Sachunterricht
Authors: Quittkat Laisa M. , Hormann Kathrin , Schomaker Claudia , Hartmann Linda 
Published: May 2023

Im Rahmen des Beitrags werden Konzeptdialoge als Aufgabenformate für die Entwicklung gemeinsamer fachlich tragfähiger Erklärungen in einer heterogenen Lerngruppe zu einem naturwissenschaftlich-technischen Phänomen sowie als Erhebungsmethode zur Erfassung von Vorstellungen und Präkonzepten von Schüler*innen für den inklusiven Sachunterricht vorgestellt. Fortführend werden Konzeptdialoge sowohl als Aufgabenformate als auch als Erhebungsmethode für den Einsatz in der ersten Phase der Lehrer*innenbildung, angelehnt an die Reflexion Masterstudierender in einem modulbezogenen Projekt mit Konzeptdialogen zum Phänomen Kuchenbacken, diskutiert.

Abstract
In this article, concept dialogues are presented as task formats for the development of common, professionally viable explanations in a heterogeneous learning group about a scientific-technical phenomenon, as well as a survey method for recording students' conceptions and pre-conceptions for inclusive Sachunterricht. Further, conceptual dialogues are discussed both as task formats and as a data collection method for use in the first phase of teacher education, based on the reflections of Master's students in a module-related project with conceptual dialogues on the phenomenon of baking cakes.
ANALISIS PENGARUH PRODUK PEMBIAYAAN DAN RISIKO TERHADAP PROFITABILITAS BANK UMUM SYARIAH PERIODE 2014-2021
Authors: Pradana Arnandho Sandhi , Erdkhadifa Rendra 
Published: May 2023

Abstrak: Penelitian ini bertujuan untuk menelaah dampak pembiayaan Mudharabah, Musyarakah, Murabahah, Risiko Kredit dan Risiko Likuiditas atas Profitabilitas Bank Umum Syariah Periode 2014-2021. Profitabilitas merupakan suatu bagian penting bagi setiap perusahaan salah satunya pada perbankan. Sebab adanya profitabilitas yang baik tentu akan berdampak dan menjadi jaminan keberlangsungan hidup dari suatu perusahaan. Data diperoleh dengan mengakses laporan keuangan dan laporan triwulan melalui website masing-masing Bank Umum Syariah. Populasi penelitian ini yakni 14 Bank Umum Syariah yang tercatat di Bank Indonesia. Serta diperoleh sampel sebanyak 1 yakni Bank Muamalat Syariah. Selama menganalisisnya, peneliti mengunakan regresi linier berganda serta software instrumen statistik SPSS. Diperoleh hasil pengamatan dan analisis data yang telah dilaksanakan, dimana faktor pembiayaan musyarakah, mudharabah dan murabahah mempunyai dampak negatif namun tidak signifikan akan ROA. NPF secara parsial berdampak negatif signifikan akan ROA. FDR secara parsial berdampak positif signifikan akan ROA.
Kata Kunci : Mudharabah; Murabahah; Profitabilitas; Risiko Kredit; Risiko Likuiditas

Abstract: This study aims to examine the impact of mudharabah, musyarakah, murabahah financing, credit risk and liquidity risk on the profitability of Islamic Commercial Banks for the 2014-2021 Period. Profitability is an important pert for every company, one of which is banking. Because the existence of good profitability will certainly have an impact and be a guarantee for the survival of a company. Data is obtained by accessing financial reports and quartely reports through the website of each Islamic Commercial Bank. The population of this study is 14 Islamic Commercial Banks registered at Bank Indonesia. As well as obtaining a sample of 1, namely Bank Muamalat Syariah. During the analysis, the researcher used multiple linear regression and SPSS statistical instrument software. Obtained result of observations and data analysis that have been carried out, where the musyarakah, mudharabah and murabahah financing faktors have a negative but not significant impact on ROA. NPF partially has a significant negative impact on ROA. FDR partially has a significant positive impact on ROA
Keywords: Mudharabah; Murabahah; Profitability; Credit Risk; Likuidity Risk