bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA H19 regulates matrisome signature and impacts cell behavior on MSC-engineered extracellular matrices
Authors: Moura Sara Reis , Freitas Jaime , Ribeiro-Machado Cláudia , Lopes Jorge , Neves Nuno , Canhão Helena , Rodrigues Ana Maria , Barbosa Mário Adolfo , Almeida Maria Inês 
Published: March 2023

AbstractBackgroundThe vast and promising class of long non-coding RNAs (lncRNAs) has been under investigation for distinct therapeutic applications. Nevertheless, their role as molecular drivers of bone regeneration remains poorly studied. The lncRNAH19mediates osteogenic differentiation of Mesenchymal Stem/Stromal Cells (MSCs) through the control of intracellular pathways. However, the effect ofH19on the extracellular matrix (ECM) components is still largely unknown. This research study was designed to decode theH19-mediated ECM regulatory network, and to reveal how the decellularized siH19-engineered matrices influence MSC proliferation and fate. This is particularly relevant for diseases in which the ECM regulation and remodeling processes are disrupted, such as osteoporosis.MethodsMass spectrometry-based quantitative proteomics analysis was used to identify ECM components, after oligonucleotides delivery to osteoporosis-derived hMSCs. Moreover, qRT-PCR, immunofluorescence and proliferation, differentiation and apoptosis assays were performed. Engineered matrices were decellularized, characterized by atomic force microscopy and repopulated with hMSC and pre-adipocytes. Clinical bone samples were characterized by histomorphometry analysis.ResultsOur study provides an in-depth proteome-wide and matrisome-specific analysis of the ECM proteins controlled by the lncRNAH19. Using bone marrow-isolated MSC from patients with osteoporosis, we identified fibrillin-1 (FBN1), vitronectin (VTN) and collagen triple helix repeat containing 1 (CTHRC1), among others, as having different pattern levels followingH19silencing. Decellularized siH19-engineered matrices are less dense and have a decreased collagen content compared with control matrices. Repopulation with naïve MSCs promotes a shift towards the adipogenic lineage in detriment of the osteogenic lineage and inhibits proliferation. In pre-adipocytes, these siH19-matrices enhance lipid droplets formation. Mechanistically,H19is targeted by miR-29c, whose expression is decreased in osteoporotic bone clinical samples. Accordingly, miR-29c impacts MSC proliferation and collagen production, but does not influence ALP staining or mineralization, revealing thatH19silencing and miR-29c mimics have complementary but not overlapping functions.ConclusionOur data suggestH19as a therapeutic target to engineer the bone ECM and to control cell behavior.
SeisDeNet: an intelligent seismic data Denoising network for the internet of things
Authors: Sang Yu , Peng Yanfei , Lu Mingde , Zhao Chen , Li Liquan , Ma Tianjiao 
Published: March 2023

AbstractDeep learning (DL) has attracted tremendous interest in various fields in last few years. Convolutional neural networks (CNNs) based DL architectures have been successfully applied in computer vision, medical image processing, remote sensing, and many other fields. A recent work has proved that CNNs based models can also be used to handle geophysical problems. Due to noises in seismic signals acquired by geophone equipment this kind of important multimedia resources cannot be effectively utilized in practice. To this end, from the perspective of seismic exploration informatization, this paper takes informatization data in seismic signal acquisition and energy exploration field using cutting-edge technologies such as Internet of things and cloud computing as the research object, presenting a novel CNNs based seismic data denoising (SeisDeNet) architecture is suggested. Firstly, a multi-scale residual dense (MSRD) block is built to leverage the characteristics of seismic data. Then, a deep MSRD network (MSRDN) is proposed to restore the noisy seismic data in a coarse-to-fine manner by using cascading MSRDs. Additionally, the denoising problem is formulated into predicting transform-domain coefficients, by which noises can be further removed by MSRDNs while richer structure details are preserved comparing with the results in spatial domain. By using synthetic seismic records, public SEG and EAGE salt and overthrust seismic model and real field seismic data, the proposed method is qualitatively and quantitatively compared with other leading edge schemes to evaluate it performance, and some results shows that the proposed scheme can produce data with higher quality evaluation while maintaining far more useful data comparing with other schemes. The feasibility of this approach is confirmed by the denoising results, and this approach is shown to be promising in suppressing the seismic noise automatically.
The safety of perioperative dexamethasone with antiemetic dosage in surgical patients with diabetes mellitus: a systematic review and meta-analysis
Authors: Pang Qian-Yun , Wang Jing-Yun , Liang Xiao-Long , Jiang Yan , Liu Hong-Liang 
Published: March 2023

Abstract
Background
Dexamethasone is commonly used for antiemesis in surgical patients. It has been confirmed that long-term steroid use increases blood glucose level in both diabetic and non-diabetic patients, it is unclear how a single dose of intravenous dexamethasone used pre/intraoperatively for postoperative nausea and vomiting (PONV) prophylaxis would influence the blood glucose and wound healing in diabetic patients.

Methods
The Pubmed, Cochrane Library, Embase, Web of Science databases, CNKI and Google Scholar were searched. The articles reporting a single dose dexamethasone administered intravenously for antiemesis in surgical patients with diabetes mellitus (DM) were included.

Results
Nine randomized controlled trials (RCTs) and 7 cohort studies were included in our meta-analysis. The results showed that dexamethasone increased glucose level intraoperatively (MD: 0.439, 95% CI: 0.137–0.581, I2 = 55.7%, P = 0.004), at the end of surgery (MD: 0.815, 95% CI: 0.563–1.067, I2 = 73.5%, P = 0.000), on postoperative day (POD) 1 (MD: 1.087, 95% CI: 0.534–1.640, I2 = 88%, P = 0.000), on POD 2 (MD: 0.501, 95% CI: 0.301–0.701, I2 = 0%, P = 0.000), and increased peak glucose level within 24 hours of surgery (MD: 2.014, 95% CI: 0.503–3.525, I2 = 91.6%, P = 0.009) compared with control. It indicated that dexamethasone caused the increase of perioperative glucose level at different time points by 0.439 to 1.087 mmol/L (7.902 to 19.566 mg/dL), and the increase of peak glucose level within 24 hours of surgery by 2.014 mmol/L (36.252 mg/dL) compared with control. Dexmethasone had no impact on wound infection (OR: 0.797, 95%CI: 0.578–1.099, I2 = 0%, P = 0.166) and healing (P < 0.05).

Conclusion
Dexamethasone could increase blood glucose by only 2.014 mmol/L (36.252 mg/dL) of peak glucose level within 24 hours of surgery in surgery patients with DM, the increase of glucose level at each time point perioperatively was even lower, and had no effect on wound healing. Thus, dexamethasone with a single dose could be safely used for PONV prophylaxis in diabetic patients.

Trial registration
The protocol of this systematic review was registered in INPLASY with the registration number INPLASY202270002.
Segmentation characteristics of deep, low-frequency tremors in Shikoku, Japan using machine learning approaches
Authors: Chen Kate Huihsuan , Chiu Hao-Yu , Obara Kazushige , Liu Yi-Hung 
Published: March 2023

AbstractShikoku island, southwestern Japan lies in the western Nankai Trough and showcases along-strike segmentation of slow earthquake behavior. Whether the spatial variation of tremor behavior reflects the regional differences in structure/source properties and how much such differences can be recognized by the seismic signals themselves are two questions addressed in this paper. Taking advantage of advanced methods in recognizing and classifying signals using machine learning approaches, we attempt to answer them by conducting signal classification experiments in Shikoku. Based on the tremor catalog from 1 June 2014 to 31 March 2015, the tremors recorded in four different areas were treated as different classes and segmented into 60-s-long signals. The number of tremors in four different areas (A to D, from west to east) reached 15,000, 31,000, 10,000, and 16,000, respectively. To efficiently distinguish between tremors from different areas, we applied ak-nearest neighbor (k-NN) classifier with Fisher’s class separability criteria to select the optimal feature subset. The resulting classification performance reached more than 90% at all 12 stations. We further designed a triangle test to select the features that can better represent the differences in source properties between areas. We found that the most efficient features were associated with (1) the number of peaks in the temporal evolution of discrete Fourier transforms and (2) the energy distribution in the autocorrelation function (ACF). To match the difference in behavior revealed by the ACF, the size of the tremor zone, which mainly controls how long the seismic energy lasts in a tremor episode, was determined to be largest in Area B and smallest in Area C. The heterogeneity of the asperities in a tremor zone, which may control how spiky the tremor signals developed over time, was determined to be strong in Areas B and C. Together with previously documented variations in slow earthquake behavior in the same area, we finally propose a conceptual model that provides a better understanding of the regional differences in the tremor source properties in Shikoku, Japan.Graphical Abstract
Challenges and opportunities for expatriate faculty teaching graduation seminar classes in Japanese universities
Authors: Hawkes Martin , Adamson Calum 
Published: March 2023

AbstractThis paper considers the issues facing expatriate instructors teaching English as a Medium of Instruction (EMI) graduation seminars (commonly known as the “zemi” in Japan) in Japanese universities and aims to establish better conditions to build Communities of Practice. Since the term “graduation seminar” is widely used globally, and might lead to preconceptions from readers, zemi is the term that will be used in this paper as a common example of Japanese English. This class is one that typically involves aspects of academic mentoring, pastoral care and socialization that differentiate it from regular classes. Lacking any personal experience of the zemi, teachers educated overseas are likely to have different expectations of the system than their domestic colleagues and students, creating a significant challenge in how they design and implement programmes. To investigate these issues, 14 semi-structured qualitative interviews were conducted with expatriate teachers of EMI zemis. Common themes described by informants included difficulties in creating a cohesive syllabus with limited support, challenges posed by thesis supervision, and mixed feelings towards mentoring and pastoral care. The data also revealed unique opportunities afforded to foreign instructors of these classes, which were unlikely to be available if they had not been entrusted with teaching a zemi. This paper seeks to fill a gap in the literature and provide insights into how foreign instructors experience the zemi. The knowledge gained can be employed to help develop Communities of Practice for such teachers. It is also hoped it will be of significance to those interested in comparative education, faculty asked to teach within educational systems of which they do not have personal experience, and anyone who works with Japanese learners, either in Japan or as international students.
GET FIT: A Randomized Clinical Trial of Tai Ji Quan Versus Strength Training for Fall Prevention After Chemotherapy in Older, Postmenopausal Women Cancer Survivors
Authors: Winters-Stone Kerri M. , Horak Fay , Dieckmann Nathan F. , Luoh Shiuh-Wen , Eckstrom Elizabeth , Stoyles Sydnee A. , Roeland Eric J. , Li Fuzhong 
Published: March 2023

PURPOSE To compare the efficacy of tai ji quan versus strength training to prevent falls after chemotherapy in older, postmenopaual women. METHODS We conducted a three-arm, single-blind, randomized controlled trial where older (50+ years), postmenopausal women cancer survivors participated in one of three supervised group exercise programs (tai ji quan, strength training, or stretching control) twice weekly for 6 months and were followed up 6 months after training stopped. The primary outcome was the incidence of falls. Secondary outcomes included fall-related injuries, leg strength (1 repetition maximum; kg), and balance (sensory organization [equilibrium score] and limits of stability [LOS; %] tests). RESULTS Four hundred sixty-two women were enrolled (mean age, 62 ± 6.3 years). Retention was 93%, and adherence averaged 72.9%. In primary analysis, there was no difference in the incidence of falls between groups after 6 months of training, nor during 6-month follow-up. A post hoc analysis detected a significantly reduced incidence of fall-related injuries within the tai ji quan group over the first 6 months, dropping from 4.3 falls per 100 person-months (95% CI, 2.9 to 5.6) at baseline to 2.4 falls per person-months (95% CI, 1.2 to 3.5). No significant changes occurred during 6-month follow-up. Over the intervention period, leg strength significantly improved in the strength group and balance (LOS) improved in the tai ji quan group, compared with controls ( P < .05). CONCLUSION We found no significant reduction in falls for tai ji quan or strength training relative to stretching control in postmenopausal women treated with chemotherapy.
High-Performance Liquid Chromatography–Mass Spectrometry–based Metabolic Profiling of Adult Growth Hormone Deficiency
Authors: Yang Hongbo , Chen Meiping , Wang Yujie , Jiang Lingjuan , Wang Linjie , Duan Lian , Gong Fengying , Zhu Huijuan , Pan Hui 
Published: March 2023

Abstract

Context
Patients with adult growth hormone deficiency (AGHD) are at increased risk of metabolic syndrome. Metabolic profiles in AGHD patients have been insufficiently evaluated.

Objective
This work aims to explore serum metabolite profiles by metabolomics analysis and assess potential metabolites associated with recombinant human growth hormone (rhGH) treatment.

Methods
Thirty-one AGHD patients and 31 healthy controls were enrolled. Untargeted ultra-performance liquid chromatography–coupled mass spectroscopy was conducted in all patients and controls at baseline and during 12 months of rhGH treatment in 11 AGHD patients. Data were processed by principal component analysis, variable importance in projection scoring, orthogonal partial least squares–discriminant analysis, and MetaboAnalyst 5.0. We further explored the associations between metabolites and clinical parameters.

Results
Metabolomics indicated a distinct metabolic pattern between AGHD patients and healthy controls. The perturbed pathways mainly include the biosynthesis of unsaturated fatty acids, sphingolipid metabolism, glycerophospholipid metabolism, fatty acid elongation, degradation, and biosynthesis. rhGH treatment increased the levels of specific glycerophospholipids compounds and reduced fatty acid ester compounds. Significant correlations existed between the 40 identified metabolites and insulin-like growth factor-1 SD score (IGF-1 SDS), body composition, and glucose and lipid metabolism plasma markers. During rhGH treatment, there was a statistically significant negative correlation between deoxycholic acid glycine conjugate and waist-to-hip ratio, while a statistically significant positive correlation existed between decanoylcarnitine and serum low-density lipoprotein levels.

Conclusion
AGHD patients have unique metabolomic profiles. rhGH treatment alters the serum levels of several fatty acid compounds/amino acids, which may contribute to the improvement of metabolic status in AGHD patients.
Ecologies, One and All
Authors: Rademacher Anne , Cadenasso Mary L. , Pickett Steward T. A. 
Published: March 2023

AbstractThis essay considers ecology in its singular and plural forms. It asks whether and how the knowledge forms generated by practitioners of the singular science of ecology might weave more fully into a robust plural analytic that is grounded in the acknowledgment of multiple ways of knowing, experiencing, and attributing meaning to consequential connections between the human and the more-than-human world. Although Western science, with singular ecology as one of its many descendants, leaves an undeniable imprint, the essay aims to ask whether the contemporary, lived life of ecological science as postpositivist practice might be working in ways that, while imperfect, may be more legible and shared with scholars in the environmental humanities than is usually noted. It describes the knowledge base of the singular science of ecology, which in contemporary theory and practice consists of collections of disparate, complementary, or contradictory models—ecologies—in the plural, thus holding generality and infinite particularity in constant dialogue. The authors, two natural scientists and one social scientist, aim to provoke fresh discussions about the ways ecological analytics circulate in contemporary research and scholarly practice. The authors’ goal is to further the essential work of more direct and clear conversation, translation, and mutual learning between scholars in the environmental humanities and biophysical ecology. They hold this to be essential as transdisciplinary initiatives endeavor to study, and better understand, how social and environmental change coproduce one another.
On a Flexible Car Use Restriction Policy: Theory and Experiment
Authors: Jiang Rui , Han Xiao , Sun Xiao-Yan , Sun Kai-Jia , Wang Wen-Xu , Zhang H. M. , Zhang Bo-Yu , Gao Zi-You 
Published: March 2023

Car use restrictions have been adopted in some mega cities that experience rapid car ownership increase and worsening traffic congestion. Although easy to implement and considered fair, most implementations of this travel demand management policy do not offer travelers the flexibility to choose the days that they cannot use their cars. In this paper, we study a flexible car use restriction policy under which a private car cannot be driven on a certain day of a week, but the day can be chosen by its owner. Under this flexible policy, individuals face a dilemma between driving in congestion and traveling without a car, each incurring a cost of its own. The resulting equilibrium solutions under these two competing choices were derived, and a series of laboratory experiments were carried out to validate the theoretical results. The experimental results are found to be in agreement with the theoretical results. Moreover, our analysis shows that the flexible car use restriction policy reduces the average travel cost with a lesser increase in average driving cost when compared with the traditional car use restriction policy. Funding: Z.-Y. Gao was supported by the National Natural Science Foundation of China [Grant 71621001]. W.-X. Wang was supported by the National Natural Science Foundation of China [Grant 71631002]. R. Jiang was supported by the National Natural Science Foundation of China [Grant 71931002]. X.-Y. Sun was supported by the National Natural Science Foundation of China [Grant 71961002]. B.-Y. Zhang was supported by the National Natural Science Foundation of China [Grants 71922004 and 72131003]. X. Han was supported by the National Natural Science Foundation of China [Grant 71801011] and by the China Postdoctoral Science Foundation [Grant 2018M631331]. Supplemental Material: The e-companion is available at https://doi.org/10.1287/trsc.2023.1200 .
Vladimir Propp’un Yapısal Çözümleme Yöntemi Üzerinden Kızılırmak Karakoyun Filminin İncelenmesi
Authors: AKDEMİR DİLEK Buket 
Published: March 2023

Anlatı kavramı Batı tarafından uzun yıllar tartışılan, üzerine düşünülen ve çalışılan bir alan olmuştur. İçerisinde anlatı barındıran metinlerin belirli bir çizgide incelenmesi ve bunun paralelinde bilimlerin ve çalışmaların ortaya çıkmasını amaçlayan bir disiplindir. Anlatı kavramı içerisinde birçok sanat dalı barındırmaktadır. Bu kavram; sözlü sanattan, yazılı sanata devamında görsel sanatlara kadar kendine yer bulmuştur. Anlatı tarzı gelişen teknolojiler ve toplumsal yapı paralelinde değişime uğrayabilmektedir. Aracı olan araç değişmiş olsa bile anlatının özelliği değişmemektedir. Vladimır Propp’un Rus masallar üzerine yaptığı biçimbilimsel yaklaşım olan yapısal çözümleme yöntemi bugün sinema sanatında karşımıza çıkmaktadır.
Bu çalışmada, Vladımır Propp’un masal çözümleme metodu olarak adlandırılan yapısal çözümleme yöntemini Lütfi Ömer Akad yönetmenliğinde çekilen Kızılırmak Karakoyu filmi üzerinde uygulanmıştır. Propp bu çalışmayı olağanüstü masallar üzerine gerçekleştirmiş olsa da anlatı yapısının sunduğu imkânlar doğrultusunda displinlerarası olarak bu yöntemi sinemada uygulamak mümkündür. Özellikle hikâyesini efsanelere, mitlere dayandıran sinema filmleri için bu çözümleme yöntemini kullanmak uygundur. İsmi geçen film, Propp’un Masalın Biçimbilimi adlı kitabında yer verdiği kuram çerçevesinde incelenmiştir. Anadolu’da geçen iki farklı efsane olan Kızılırmak efsanesi ile Karakoyun efsanesini bir araya getiren filmin olay dizgisi yapısal çözümleme yönteminin birçok işlevini karşıladığı görülmektedir.

The concept of narrative has been a field that has been discussed, thought about and studied by the West for many years. It is a discipline that aims to examine texts containing narratives in a certain line and to reveal sciences and studies in parallel with this. This concept; It has found a place for itself from oral art to written art and then to visual arts. From oral art to written art, it has found a place for itself in visual art. Narrative style can change in parallel with developing technologies and social structure. The character of the narrative does not change, even if the vehicle that is the mediator has changed. Structural analysis method, which is the morphological approach of Vladimir Propp on Russian fairy tales, appears in the art of cinema today.
In this study, the structural analysis method of Vlamar Propp, called the tale analysis method, was applied on the film Kızılırmak Karakoyu, which was directed by Lütfi Ömer Akad. Although Propp has carried out this work on extraordinary tales, it is possible to apply this method in cinema interdisciplinary in line with the possibilities offered by the narrative structure. The aforementioned film has been analyzed within the framework of the theory that Propp has included in his book Morphology of the Tale. It is seen that the film, which brings together the legend of Kızılırmak and the legend of Karakoyun, which are two different legends in Anatolia, fulfills many functions of the event string structural analysis method.