bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opportunities and Challenges of Establishing a Regional Bio‐based Polylactic Acid Supply Chain
Authors: Abdelshafy Ali , Hermann Alina , Herres‐Pawlis Sonja , Walther Grit 
Published: May 2023

AbstractPolylactic acid (PLA) is the bioplastic with the highest market share. However, it is mainly produced from first‐generation feedstock and there are various inconsistencies in the literature in terms of its production and recycling processes, carbon footprint, and prices. The aim of this study is to compile and contrast these aspects and investigate second‐generation PLA production from technical, economic, and ecological perspectives simultaneously. The comprehensive analyses also show the chances and challenges of originating a PLA supply chain in a specific region. Herein, the German Federal State of North Rhine‐Westphalia (NRW) has been chosen as a region of interest. In addition to highlighting the industrial capabilities and synergies, the study quantifies and illustrates the locations of different suitable second‐generation feedstocks in the region. However, the identified potentials can be challenged by various obstacles such as the high demand of bioresources, feedstock quality, spatial aspects, and logistics. Furthermore, the substantial price gap between PLA and fossil‐based plastics can also discourage the investors to include PLA on their portfolios. Thus, the study also provides recommendations to overcome these obstacles and promote the regional value chains of bioplastics which may serve as prototype for other regions.
Late Roman–Early Byzantine Leukos settlement, Karpathos, Greece: Geoarchaeology, archeoseismology, and paleogeography
Authors: Kleinspehn Karen L. , Nelson Michael C. 
Published: May 2023

AbstractThis archeoseismologic study focuses on the Leukos settlement that thrived on the west coast of the forearc island of Karpathos in the 4th−6th centuries CE. The onshore site occupies the eastern rim of the offshore Karpathos Basin, the deepest Aegean basin, in a sector of the Hellenic forearc typically regarded as seismically insignificant. Investigations of faulting, sedimentary processes, and secondary earthquake effects (hydraulic fracturing, liquefaction, tilting, landslides) are integrated with observations of previously surveyed and newly discovered archeological remains to appraise syn‐ to post‐Early Byzantine seismicity and establish a sequence of faulting. Calibrated radiocarbon dates, the first from Karpathos, indicate intermittent faulting and seismicity spanning the 4th−10th centuries CE, likely contributing to the early 7th‐century CE abandonment of Leukos. The coseismic rupture of competent cobbles whose fractures are filled with fluidized sediment is an established paleoseismologic tool for recognizing earthquakes of magnitude Mw ≥ 6; this study extends that criterion to archeoseismology. This study underscores the need to evaluate land movements, sea‐level fluctuations, and shoreline migration for coastal archeological sites. A plausible Late Roman paleogeography emerges in which Leukos occupied a contiguous peninsula rather than surrounding three modern harbors. This study encourages re‐evaluation of seismic and tsunami hazards in the sector of the Hellenic forearc surrounding ancient Leukos and the Karpathos Basin.
Suicidal ideation among people with Parkinson's disease and comparison with a control group
Authors: Santos‐García Diego , de Deus Fonticoba Teresa , Cores Bartolomé Carlos , Feal Panceiras Maria J. , García Díaz Iago , Íñiguez Alvarado Maria Cristina , Jesús Silvia , Boungiorno Maria Teresa , Planellas Lluís , Cosgaya Marina , García Caldentey Juan , Caballol Nuria , Legarda Ines , Hernández Vara Jorge , Cabo Iria , López Manzanares Lydia , González Aramburu Isabel , Ávila Rivera Maria A. , Gómez Mayordomo Víctor , Nogueira Víctor , Puente Víctor , Dotor García‐Soto Julio , Borrué Carmen , Vila Berta Solano , Álvarez Sauco María , Vela Lydia , Escalante Sonia , Cubo Esther , Carrillo Padilla Francisco , Martínez Castrillo Juan C. , Sánchez Alonso Pilar , Alonso Losada Maria G. , López Ariztegui Nuria , Gastón Itziar , Kulisevsky Jaime , Blázquez Estrada Marta , Seijo Manuel , Rúiz Martínez Javier , Valero Caridad , Kurtis Mónica , de Fábregues Oriol , González Ardura Jessica , Alonso Redondo Ruben , Ordás Carlos , López Díaz Luis M. , McAfee Darrian , Martinez‐Martin Pablo , Mir Pablo ,   COPPADIS Study Group
Published: May 2023

AbstractBackgroundDetection of suicidal ideation (SI) is key for trying to prevent suicide. The aim of this study was to analyze the frequency of SI and related factors in Spanish people with Parkinson's Disease (PwPD) and to compare them with a control group.MethodsPD patients and controls recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. Two visits were conducted: V0 (baseline); V2 (2‐year ± 1 month follow‐up). SI was defined as a score ≥1 on item nine of the Beck Depression Inventory‐II (BDI‐II). Regression analyses were conducted to identify factors related to SI.ResultsAt baseline, 693 PwPD (60.2% males; 62.59 ± 8.91 years old) and 207 controls (49.8% males; 60.99 ± 8.32 years old) were included. No differences between PwPD and controls were detected in SI frequency at either V0 (5.1% [35/693] vs. 4.3% [9/207];p = 0.421) or at V2 (5.1% [26/508] vs. 4.8% [6/125];p = 0.549). Major depression (MD) and a worse quality of life were associated with SI at both visits in PwPD: V0 (MD, OR = 5.63;p = 0.003; PDQ‐39, OR = 1.06;p = 0.021); V2 (MD, OR = 4.75;p = 0.027; EUROHIS‐QOL8, OR = 0.22;p = 0.006). A greater increase in the BDI‐II total score from V0 to V2 was the only factor predicting SI at V2 (OR = 1.21;p = 0.002) along with an increase in the total number of non‐antiparkinsonian drugs (OR = 1.39;p = 0.041).ConclusionThe frequency of SI (5%) in PwPD was similar to in controls. Depression, a worse quality of life, and a greater comorbidity were related to SI.
Discovering associations between radiological features and COVID‐19 patients' deterioration
Authors: Ahmadinejad Nasrin , Ayyoubzadeh Seyed Mohammad , Zeinalkhani Fahimeh , Delazar Sina , Javanmard Zohreh , Ahmadinejad Zahra , Mohajeri Amirhassan , Esmaeili Marzieh 
Published: May 2023

AbstractBackground and AimsData mining methods are effective and well‐known tools for developing predictive models and extracting useful information from various data of patients. The present study aimed to predict the severity of patients with COVID‐19 by applying the rule mining method using characteristics of medical images.MethodsThis retrospective study has analyzed the radiological data from 104 COVID‐19 hospitalized patients diagnosed with COVID‐19 in a hospital in Iran. A data set containing 75 binary features was generated. Apriori method is utilized for association rule mining on this data set. Only rules with confidence equal to one were generated. The performance of rules is calculated by support, coverage, and lift indexes.ResultsTen rules were extracted with only X‐ray‐related features on cases referred to ICU. The Support and Coverage index of all of these rules was 0.087, and the Lift index of them was 1.58. Thirteen rules were extracted from only CT scan‐related features on cases referred to ICU. The CXR_Pleural effusion feature has appeared in all the rules. The CXR_Left upper zone feature appears in 9 rules out of 10. The Support and Coverage index of all rules was 0.15, and the Lift index of all rules was 1.63. the CT_Adjacent pleura thickening feature has appeared in all rules, and the CT_Right middle lobe appeared in 9 rules out of 13.ConclusionThis study could reveal the application and efficacy of CXR and CT scan imaging modalities in predicting ICU admission to a major COVID‐19 infection via data mining methods. The findings of this study could help data scientists, radiologists, and clinicians in the future development and implementation of these methods in similar conditions and timely and appropriately save patients from adverse disease outcomes.
Production of exopolysaccharides with a high emulsifying activity using an Idiomarina strain under different conditions of oxygen transfer and temperature
Authors: García Andrés , Mercado‐Muñoz Liliana , Fernández‐Sandoval Marco T , Morales‐Guzmán Daniel , Martínez‐Morales Fernando , Trejo‐Hernández María R 
Published: May 2023

AbstractBackgroundMarine microbial exopolysaccharides are the most significant group of polymeric material biopolymers on earth; they exhibit many potential applications in industrial, medical, and environmental fields, due to their chemical structure, which determines their functional properties. This study aimed to evaluate the production and the emulsifying activity of the exopolysaccharides produced by Idiomarina sp. B7H2 cultured under different oxygen transfer rates (OTR) and incubation temperatures.ResultsIn cultures developed at low incubation temperatures (15 °C), an increase in OTRmax from 4.2 to 8 mmol L−1 h−1 promoted cellular growth and exopolysaccharide production, reaching a dry weight biomass of 7.7 ± 0.03 g L−1 and a maximal exopolysaccharide production of 4.28 ± 0.14 g L−1. In contrast, at high incubation temperature (25 °C) and at high OTRmax of 8 mmol L−1 h−1, a maximal emulsifying activity of 75.5% was obtained. This value was higher with respect to that obtained at the lower OTRmax (4.2 mmol L−1 h−1). However, higher emulsifying activity was not related to the synthesis of exopolysaccharides.ConclusionOverall, our results indicate that by controlling the OTRmax and incubation temperatures it is possible to manipulate the production and the emulsifying activity of the bacterial exopolysaccharide produced by B7H2 strain, mainly carrying out the fermentation process at high incubation temperatures and higher OTRmax. © 2023 Society of Chemical Industry (SCI).
A critical evaluation of soil salinization, waterlogging, and agricultural productive capacity in Hohokam irrigation of the Phoenix Basin, Arizona, USA
Authors: Caseldine* Christopher R. 
Published: May 2023

AbstractA causal link between environmental degradation and societal collapse has captivated the imagination of generations of archaeologists, historians, and the public. At its core, it is believed that the agricultural aspirations of societies outstrip what the environment can offer. The Hohokam, who farmed the Phoenix Basin of Arizona, USA, for nearly a millennium (AD 475–1450), have been repeatedly used as an exemplar of incongruence between the environment and agricultural practices leading to crop failures and ultimately societal collapse. Contributing to the collapse narrative is crop failures that spread across the lower Salt River Valley during the late 1800s. Unacknowledged by collapse narratives is that unproductive fields were brought back to life at the start of the twentieth century with techniques not beyond the capability of the Hohokam. Hohokam farmers and their descendants maintained and prospered in the valley for more than a millennium, so the assumed unidirectionality toward degraded productive capacity warrants examination. In this article, five lines of evidence are used to assess the relationships among soil salinization, waterlogging, and agricultural productive capacity. The multistep approach reveals that available evidence fails to substantiate soil salinization and waterlogging as primary catalysts in the decline of Hohokam irrigation. As such, establishing causality between environmental factors and societal decline in the past requires multiple lines of evidence producing contextually detailed syntheses, rather than simple models.
Chronological constraint of Neanderthal cultural and environmental changes in southwestern Europe: MIS 5–MIS 3 dating of the Axlor site (Biscay, Spain)
Authors: Demuro Martina , Arnold Lee J. , González‐Urquijo Jesús , Lazuen Talia , Frochoso Manuel 
Published: May 2023

ABSTRACTThe cave site of Axlor (Biscay, Spain) preserves one of the most informative Middle Palaeolithic (MP) records for the North Atlantic Iberian region, though its age remains poorly known. Here we use single‐grain optically stimulated luminescence (OSL) and single‐grain thermally transferred OSL (TT‐OSL) dating of sediments to improve the age constraint of Axlor's MP succession (levels N–B). Our new ages are consistent with the previously publishedterminus ante quem14C ages for the site (>42.9 cal kabp), and suggest the sequence accumulated during a period of ~50 kyr. Axlor's levels N–F were deposited ~100–80 ka, probably during marine isotope stage (MIS) 5d–a, while levels D and B were deposited ~70 and ~50 ka, respectively, during MIS 4 and mid‐MIS 3. Our results indicate that major faunal and technological turnovers occurred towards the end of MIS 5, potentially coinciding with broader environmental and climatic changes. Axlor's Quina record, dated here to the onset of MIS 4, is one of the oldest in Europe. Comparisons with neighbouring sites point to complex regional chronologies and development for this particular behaviour, though detailed correlations with other MP sequences remain difficult due to their poor chronological attributes. The present study highlights the important role that single‐grain optical dating can play in elucidating the broader evolution of the MP across southwestern Europe.
Effects of roasting and ultrasound‐assisted enzymatic treatment of Nigella sativa L. seeds on thymoquinone in the oil and antioxidant activity of defatted seed meal
Authors: Mashhadi Abolghasem Fatemeh , Kim Ryun Hee , Park Sun Young , Lim Taehwan , Lee Haeseong , Hwang Keum Taek , Kim Jaecheol 
Published: May 2023

AbstractBACKGROUNDBlack cumin seeds (black seed; BS) contain various bioactive compounds, such as thymoquinone (TQ). Roasting and ultrasound‐assisted enzymatic treatment (UAET) as pre‐treatments can increase the phytochemical content in the BS oil. This study aimed to investigate the effects of pre‐treatments on the TQ content and the yield of the BS oil and to profile the composition of defatted BS meal (DBSM), followed by evaluating antioxidant properties of the DBSM.RESULTSThe extraction yield of crude oil from BS was not affected by the roasting time. The highest extraction yield (47.8 ± 0.4%) was obtained with UAET cellulase‐pH 5 (enzyme concentration of 100%). Roasting decreased the TQ content of the oil, while the UAET cellulase‐pH 5 treatment with an enzyme concentration of 100% yielded the highest TQ (125.1 ± 2.7 μg mL−1). Additionally, the UAET cellulase‐pH 5 treatment increased total phenolics and flavonoids of DBSM by approximately two‐fold, compared to roasting or ultrasound treatment (UT) alone. Principal component analysis revealed that the UAET method might be more suitable for extracting BS oil with higher TQ content than roasting and UT.CONCLUSIONCompared to roasting or UT, using ultrasound along with cellulase could improve the oil yield and TQ in the oil from BS and obtain the DBSM with higher phenolics, flavonoids, and antioxidant activity. © 2023 Society of Chemical Industry.
Senior citizens’ vitamin D supplements intake: evidence from Denmark
Authors: Caso Gerarda , Grønhøj Alice , Vecchio Riccardo , Videbæk Pernille Nørgaard , Lähteenmäki Liisa 
Published: May 2023

AbstractBACKGROUNDSeveral public interventions have been designed in recent years to urge the intake of vitamin D supplements among the senior population to avoid the direct and indirect consequences associated with vitamin D deficiency. However, the effectiveness of these public campaigns remains quite limited. In an online survey, the current study investigates attitudes towards vitamin D supplements intake and associated behaviours in a representative sample of Danish senior citizens (N = 554) – that is, individuals aged 55 years and above.RESULTSApproximately half of the sample reported taking vitamin D supplements in the preceding year. Furthermore, being male and having a positive perception of individuals’ own health status increased the probability of being a non‐user. Increasing confidence in the information provided by health authorities (such as medical doctors and pharmacies) is particularly critical for enhancing the likelihood of non‐users to purchase vitamin D supplements. However, also encouraging the uptake of vitamin D supplements in specialized supermarkets with stands and promotions seems an appealing and practical solution to increase seniors’ uptake of vitamin D supplements.CONCLUSIONSThe present study outlines the characteristics of senior Danish non‐users of vitamin D supplements. Additionally, the research provides information on the strategies that could be applied by public organizations to foster vitamin D supplements intake among this target segment of the population. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Extraction and isolation of diphenylheptanes and flavonoids fromAlpinia officinarumHance using supercritical fluid extraction followed by supercritical fluid chromatography
Authors: Wu Di , Ge Dandan , Dai Yingping , Chen Yanchun , Fu Qing , Jin Yu 
Published: May 2023

In this paper, an off‐line combination method of supercritical fluid extraction and supercritical fluid chromatography was developed for the selective extraction and isolation of diphenylheptanes and flavonoids fromAlpinia officinarumHance. The enrichment of target components was successfully achieved using supercritical fluid extraction with the following conditions (8% ethanol as co‐solvent at 45°C and 30 MPa for 30 min). Taking full advantage of the complementarity of supercritical fluid chromatography stationary phases, a two‐step preparative supercritical fluid chromatography strategy was constructed. The extract was firstly divided into seven fractions on a Diol column (250 × 20 mm internal diameter, 10 μm) within 8 min by gradient elution increasing from 5% to 20% modifier (methanol) at 55 ml/min and 15 MPa. Then the seven fractions were separated by using a 1‐AA or a DEA column (250 × 19 mm internal diameter, 5 μm) at 50 ml/min and 13.5 MPa. This two‐step strategy showed superior separation ability for structural analogs. As a result, seven compounds, including four diphenylheptanes and three flavonoids with high purity, were successfully obtained. The developed method is also helpful for the extraction and isolation of other structural analogs of traditional Chinese medicines.
Value propositions in KIBS: How to facilitate the communication of value?
Authors: Heikka Eija‐Liisa 
Published: May 2023

AbstractThis study explores value propositions in knowledge‐intensive business services (KIBS). More specifically, this study investigates how to facilitate the effective communication of value to customers in the KIBS context by employing a qualitative case study method. The findings address the importance of trust in developing a solid client relationship to foster successful collaboration and open communication, thus creating a basis for constructing customer knowledge, and also indicate that the phase and intimacy of the relationship both influence which criteria are emphasised during the purchasing process. Consequently, this study challenges the idea that value propositions are always co‐created at every phase of the KIBS customer relationship, and it distinguishes the factors that facilitate the communication of value in these relationships. The understanding gained through this study offers practical insights and will help KIBS firms successfully communicate value to their clients.
Hard–Soft Thermoset Alloy with Enhanced Toughness, Impact‐Resistance, and Electric Conductivity via Interpenetrated Dynamic Crosslinked Interface
Authors: Zhang Qiang , Zhang Peng , Ge Zhishen , Wang Xiaohong , Chen Xiaoming , Wu Shilong , Chen Quan , Liang Chenyu , Cheng Yilong , Zhang Yanfeng 
Published: May 2023

AbstractPolymer alloys (PAs) are mixtures of two or more types of polymers to enhance the properties of polymeric materials. However, thermosets with crosslinked structures are immiscible and cannot be prepared PAs. Herein, two immiscible covalent adaptable networks containing phenoxy carbamate bonds are explored as the typical polymeric materials to prepare the hard–soft thermoset alloy (HSTA) by the interpenetrated dynamic crosslinked interface (IDCI) to enhance the toughness. Specifically, two types of polyurethane covalent adaptable networks with either high stiffness (thermoset) or extensibility (elastomer) are prepared, respectively. The granules of thermoset and elastomer are mixed and hot‐pressed to prepare the HSTA. The HSTA shows improved mechanical properties with a toughness of 22.8 MJ m−3 which is 14 times higher than that of hard thermoset. In addition, the HSTA shows excellent impact‐resistance property after 1000 punctures. Moreover, the obtained HSTA via addition of carbon nanotubes can significantly decrease the electric resistance over six orders of magnitudes as compared to the blending method, which is due to the distribution of the carbon nanotubes at the interfaces of the two networks.
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
Authors: Al‐Sharshani Dalal , Velayutham Dinesh , Samara Muthanna , Gazal Reham , Al Haj Zen Ayman , Ismail Mohamed A. , Ahmed Mahmoud , Nasrallah Gheyath , Younes Salma , Rizk Nasser , Hammuda Sara , Qoronfleh M. Walid , Farrell Thomas , Zayed Hatem , Abdulrouf Palli Valapila , AlDweik Manar , Silang John Paul Ben , Rahhal Alaa , Al‐Jurf Rana , Mahfouz Ahmed , Salam Amar , Al Rifai Hilal , Al‐Dewik Nader I. 
Published: May 2023

AbstractBackgroundDyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non‐alcoholic fatty liver disease (NAFLD).ObjectiveThe study aimed to investigate the association between selected single nucleotide polymorphisms (SNPs) with dyslipidemia and increased susceptibility risks of CVD, NAFLD, and/or T2DM in dyslipidemia patients in comparison with healthy control individuals from the Qatar genome project.MethodsA community‐based cross‐sectional study was conducted among 2933 adults (859 dyslipidemia patients and 2074 healthy control individuals) from April to December 2021 to investigate the association between 331 selected SNPs with dyslipidemia and increased susceptibility risks of CVD, NAFLD and/or T2DM, and covariates.ResultsThe genotypic frequencies of six SNPs were found to be significantly different in dyslipidemia patients subjects compared to the control group among males and females. In males, three SNPs were found to be significant, the rs11172113 in over‐dominant model, the rs646776 in recessive and over‐dominant models, and the rs1111875 in dominant model. On the other hand, two SNPs were found to be significant in females, including rs2954029 in recessive model, and rs1801251 in dominant and recessive models. The rs17514846 SNP was found for dominant and over‐dominant models among males and only the dominant model for females. We found that the six SNPs linked to gender type had an influence in relation to disease susceptibility. When controlling for the four covariates (gender, obesity, hypertension, and diabetes), the difference between dyslipidemia and the control group remained significant for the six variants. Finally, males were three times more likely to have dyslipidemia in comparison with females, hypertension was two times more likely to be present in the dyslipidemia group, and diabetes was six times more likely to be in the dyslipidemia group.ConclusionThe current investigation provides evidence of association for a common SNP to coronary heart disease and suggests a sex‐dependent effect and encourage potential therapeutic applications.