bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral and craniofacial research in the Generation R study: an executive summary
Authors: van Meijeren-van Lunteren Agatha W. , Liu Xianjing , Veenman Francien C. H. , Grgic Olja , Dhamo Brunilda , van der Tas Justin T. , Prijatelj Vid , Roshchupkin Gennady V. , Rivadeneira Fernando , Wolvius Eppo B. , Kragt Lea 
Published: June 2023

Abstract

Objectives

Oral conditions are of high prevalence and chronic character within the general population. Identifying the risk factors and determinants of oral disease is important, not only to reduce the burden of oral diseases, but also to improve (equal access to) oral health care systems, and to develop effective oral health promotion programs. Longitudinal population-based (birth-)cohort studies are very suitable to study risk factors on common oral diseases and have the potential to emphasize the importance of a healthy start for oral health. In this paper, we provide an overview of the comprehensive oral and craniofacial dataset that has been collected in the Generation R study: a population-based prospective birth cohort in the Netherlands that was designed to identify causes of health from fetal life until adulthood.

Methods
Within the multidisciplinary context of the Generation R study, oral and craniofacial data has been collected from the age of 3 years onwards, and continued at the age of six, nine, and thirteen. Data collection is continuing in 17-year-old participants.

Research outcomes
In total, the cohort population comprised 9749 children at birth, and 7405 eligible participants at the age of seventeen. Based on questionnaires, the dataset contains information on oral hygiene, dental visits, oral habits, oral health–related quality of life, orthodontic treatment, and obstructive sleep apnea. Based on direct measurements, the dataset contains information on dental caries, developmental defects of enamel, objective orthodontic treatment need, dental development, craniofacial characteristics, mandibular cortical thickness, and 3D facial measurements.

Conclusions
Several research lines have been set up using the oral and craniofacial data linked with the extensive data collection that exists within the Generation R study.

Clinical relevance
Being embedded in a multidisciplinary and longitudinal birth cohort study allows researchers to study several determinants of oral and craniofacial health, and to provide answers and insight into unknown etiologies and oral health problems in the general population.
The effect of connective tissue graft or a collagen matrix on epithelial differentiation around teeth and implants: a preclinical study in minipigs
Authors: Stähli Alexandra , Párkányi László , Aroca Sofia , Stavropoulos Andreas , Schwarz Frank , Sculean Anton , Bosshardt Dieter D. 
Published: June 2023

Abstract

Objectives

This study aimed to histologically evaluate the healing at 8 weeks after coronally advanced flap (CAF) with either a superficial (SCTG) or deep palatal connective tissue graft (DCTG), or a collagen matrix (CM) to cover recession defects at teeth and implants.

Material and methods
One mandibular side of 6 miniature pigs received each 3 titanium implants 12 weeks after extraction. Eight weeks later, recession defects were created around implants and contralateral premolars and 4 weeks later randomly subjected to CAF + SCTG, CAF + DCTG, or CAF + CM. After 8 weeks, block biopsies were histologically analyzed.

Results
For the primary outcome, i.e., keratinization of the epithelium, all teeth and implants exhibited a keratinized epithelium with no histological differences among them also not in terms of statistically significant differences in length (SCTG 0.86 ± 0.92 mm, DCTG 1.13 ± 0.62 mm, and Cm, 1.44 ± 0.76 mm). Pocket formation was histologically seen at all teeth, around most implants with SCTG and DCTG, however not in the CM implant group. The connective tissue grafts showed hardly signs of degradation, whereas the CM was partly degraded and integrated in connective tissue. The mean gain in gingival height was similar in all experimental groups (SCTG 3.89 ± 0.80 mm, DCTG 4.01 ± 1.40 mm, CM 4.21 ± 0.64 mm). Statistically significant differences were found in the height of the junctional epithelium between the control teeth and the connective tissue groups (p = 0.009 and 0.044).

Conclusions
In this animal model, the use of either a superficial or deep connective tissue graft or a collagen membrane did not seem to have any impact on the epithelial keratinization around both teeth and implants. All procedures (CAF + SCTG/DCTG/CM) resulted in a long JE that was even longer at implants.

Clinical relevance
Deep/superficial palatal connective tissue graft yielded similar keratinization around teeth/implants. Given the absence of pocket formation and inflammatory processes at implants when using a CM, CAF + CM might bear potential clinical benefits.
“I’m always going to be tired”: a qualitative exploration of adolescents’ experiences of fatigue in depression
Authors: Higson-Sweeney Nina , Cooper Kate , Dunn Barnaby D. , Loades Maria E. 
Published: June 2023

AbstractAdolescent depression is a prevalent and disabling condition, but current psychological treatments are only moderately effective. One way to enhance outcomes is to further our understanding of adolescent depression and improve our capacity to target the most frequently reported and problematic symptoms. A common but often neglected symptom of depression is fatigue, which is associated with considerable impairment and has the potential to interfere with adolescents’ engagement in psychological therapies. Despite this, the experience of fatigue in adolescent depression and how we target it in treatment is currently poorly understood. Therefore, we aimed to explore adolescents’ experiences and understandings of fatigue in depression, recruiting from clinical and community settings. Semi-structured interviews were conducted with 19 UK-based adolescents aged 14–18 years old with elevated symptoms of depression. Using reflexive thematic analysis, three themes were generated. Fatigue is a complex concept explored adolescents’ understanding of fatigue as a dynamic, multifaceted symptom which had mental and physical components. Trapped in a cycle of fatigue considered the complex and reciprocal relationship between fatigue and other depressive symptoms, and the subsequent impact of limited energy on engagement with everyday activities. Finally, stigma as a barrier to help-seeking highlighted how adolescents were reluctant to seek help due to experienced stigma and the perception that fatigue was not a serious enough symptom. Findings from this study suggest that fatigue should be viewed as a psychological as well as somatic symptom of depression, with implications regarding the identification and treatment of fatigue in depression in routine clinical practice.
Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with high tumor mutational burden tumors
Authors: Mishima Saori , Naito Yoichi , Akagi Kiwamu , Hayashi Naomi , Hirasawa Akira , Hishiki Tomoro , Igarashi Ataru , Ikeda Masafumi , Kadowaki Shigenori , Kajiyama Hiroaki , Kato Motohiro , Kenmotsu Hirotsugu , Kodera Yasuhiro , Komine Keigo , Koyama Takafumi , Maeda Osamu , Miyachi Mitsuru , Nishihara Hiroshi , Nishiyama Hiroyuki , Ohga Shouichi , Okamoto Wataru , Oki Eiji , Ono Shigeru , Sanada Masashi , Sekine Ikuo , Takano Tadao , Tao Kayoko , Terashima Keita , Tsuchihara Katsuya , Yatabe Yasushi , Yoshino Takayuki , Baba Eishi 
Published: June 2023

AbstractThe development of novel antitumor agents and accompanying biomarkers has improved survival across several tumor types. Previously, we developed recommendations for tumor-agnostic treatments in patients with solid tumors with DNA mismatch repair deficient or neurotrophic receptor tyrosine kinase fusions. Recently, immune checkpoint inhibitors have shown efficacy in patient with tumor mutation burden-high (TMB-H) solid tumors and have been established as a third tumor-agnostic agent, making it necessary to develop the guideline prioritized for these patients. Clinical questions regarding medical care were formulated for patients with TMB-H advanced solid tumors. Relevant publications were searched by PubMed and Cochrane Database. Critical publications and conference reports were added manually. Systematic reviews were performed for each clinical question for the purpose of developing clinical recommendations. The committee members identified by Japan Society of Clinical Oncology (JSCO), Japanese Society of Medical Oncology (JSMO), and Japanese society of pediatric hematology/oncology (JSPHO) voted to determine the level of each recommendation considering the strength of evidence, expected risks and benefits to patients, and other related factors. Thereafter, a peer review by experts nominated from JSCO, JSMO, and JSPHO, and the public comments among all societies' members was done. The current guideline describes three clinical questions and seven recommendations for whom, when, and how TMB should be tested, and what is recommended for patients with TMB-H advanced solid tumors. In this guideline, the committee proposed seven recommendations for performing TMB testing properly to select patients who are likely to benefit from immunotherapy.
Effect of local climate anomalies on giraffe survival
Authors: Bond Monica L. , Ozgul Arpat , Lee Derek. E. 
Published: June 2023

AbstractWith the rapid pace of global warming, there is an urgent need to understand survival responses to climate, particularly for large mammals that are already experiencing population declines associated with anthropogenic pressures such as poaching and habitat loss. We tested hypotheses about the interactive effects of local climatic anomalies (variations around a long-term mean) and proximity to edge of protected area boundaries on seasonal adult and juvenile survival in a population of 2,385 individually identified giraffes monitored over 8 years in the Tarangire Ecosystem of northern Tanzania. Temperature anomalies were positively correlated with seasonal survival of adult giraffes, suggesting these megaherbivores are adapted to hot conditions. Higher seasonal rainfall anomalies were negatively correlated with both juvenile and adult survival, and greater vegetation greenness was associated with lower adult survival. During seasons of anomalously high rainfall and vegetation greenness, higher parasite and disease abundance, poorer-quality nutrition in forage, and higher predation risk may all play a role in lowering giraffe survival. Furthermore, climate-associated reduction in survival was most pronounced during the short rainy season for adult giraffes living closer to the edge of protected areas, indicating that the influence of climate anomalies may be exacerbated by anthropogenic edge effects such as poaching or livestock keeping. Precipitation in East Africa is projected to increase substantially, with a greater proportion of rain falling during heavy events in the short rainy season, which may threaten persistence of giraffes in one of Earth’s most important landscapes for large mammals.
The prognostic significance of stroke volume index in low gradient severe aortic stenosis: from the national echo database of Australia
Authors: Snir Afik D. , Ng Martin K. , Strange Geoff , Playford David , Stewart Simon , Celermajer David S. 
Published: June 2023

AbstractApproximately 50% of patients with severe aortic stenosis (AS) in clinical practice present with ‘low-gradient’ haemodynamics. Stroke Volume Index (SVI) is a measure of left ventricular output, with ‘normal-flow’ considered as  > 35 ml/m2. The association between SVI and prognosis in severe low-gradient AS (LGAS) in currently not well-understood. We analysed the National Echo Database of Australia (NEDA) and identified 109,990 patients with sufficiently comprehensive echocardiographic data, linked to survival information. We identified 1,699 with severe LGAS and preserved ejection fraction (EF) (≥ 50%) and 774 with severe LGAS and reduced EF. One- and three-year survival in each subgroup were assessed (follow-up of 74 ± 43 months), according to SVI thresholds. In patients with preserved EF the mortality “threshold” was at SVI < 30 ml/m2; 1- and 3-year survival was worse for those with SVI < 30 ml/m2 relative to those with SVI > 35 ml/m2 (HR 1.80, 95% CI 1.32–2.47 and HR 1.38, 95% CI 1.12–1.70), while survival was similar between those with SVI 30–35 ml/m2 and SVI > 35 ml/m2. In patients with reduced EF the mortality “threshold” was 35 ml/m2; 1- and 3-year survival was worse for both those with SVI < 30 ml/m2 and 30–35 ml/m2 relative to those with SVI > 35 ml/m2 (HR 1.98, 95% CI 1.27–3.09 and HR 1.41, 95% CI 1.05–1.93 for SVI < 30 ml/m2 and HR 2.02, 95% CI 1.23–3.31 and HR 1.56, 95% CI 1.10–2.21 for SVI 30–35 ml/m2). The SVI prognostic threshold for medium-term mortality in severe LGAS patients is different for those with preserved LVEF (< 30 ml/m2) compared to those with reduced LVEF (< 35 ml/m2).
Quasi-isothermal (Q-TG), cryoporometric (DSC) and adsorption characterization of activated carbons
Authors: Charmas Barbara , Zięzio Magdalena , Jedynak Katarzyna , Kucio Karolina 
Published: June 2023

AbstractIn the presented paper, the structural and energetic heterogeneities of the activated carbons (ACs) surfaces were investigated. The ACs of well-developed microporosity were obtained from the spent coffee grounds as a result of pyrolysis (N2 or CO2) with the chemical activation of H3PO4 (I = 1, 1.5 or 2 w/w). The low-temperature N2 adsorption, the quasi-isothermal thermogravimetry as well as the low-temperature differential scanning calorimetry were employed. Moreover, the selected materials adsorption properties were studied in relation to methylene blue (MB). The micro/mesoporous structure of the carbons was proved. The different types of water clusters on the surface indicated the carbons surface heterogeneity. The activated carbons are characterized by the high sorption capacity (qe,exp = 200.3–237.67 mg g−1) as for MB. The adsorption process was described by means of the Radke–Prausnitz isotherm model.
Graphical abstract
Market expansion and the scope of mass customization
Authors: Jost Peter-J. 
Published: June 2023

AbstractWe consider a market in which two firms with their own customer base have the possibility to expand their business by customization to serve new customer segments. In a two-dimensional model, we examine the optimal scope of customization - that is, whether not to customize, to customize only one dimension, or to customize both dimensions - by analyzing the trade-off between market expansion and expected competition. Depending on the size of their own home markets, we show that in most market constellations one firm fully customizes its standard product whereas the other firm customizes maximally only one dimension. If price discrimination for customized products is possible, firms’ incentives to customize increase. However, whereas customization under uniform pricing is always Pareto improving for both firms, it might be Pareto inferior under price discrimination. From a consumer perspective, the situation is reversed. Although full customization implies that customers’ preferences are perfectly matched, they do not necessarily benefit from customization under uniform pricing, whereas price discrimination is always a Pareto improvement for customers.
Exact Simulation of Poisson-Dirichlet Distribution and Generalised Gamma Process
Authors: Dassios Angelos , Zhang Junyi 
Published: June 2023

AbstractLet $$J_1>J_2>\dots $$

J
1

>

J
2

>
⋯

be the ranked jumps of a gamma process $$\tau _{\alpha }$$

τ
α

on the time interval $$[0,\alpha ]$$

[
0
,
α
]

, such that $$\tau _{\alpha }=\sum _{k=1}^{\infty }J_k$$

τ
α

=

∑

k
=
1

∞

J
k

. In this paper, we design an algorithm that samples from the random vector $$(J_1, \dots , J_N, \sum _{k=N+1}^{\infty }J_k)$$

(

J
1

,
⋯
,

J
N

,

∑

k
=
N
+
1

∞

J
k

)

. Our algorithm provides an analog to the well-established inverse Lévy measure (ILM) algorithm by replacing the numerical inversion of exponential integral with an acceptance-rejection step. This research is motivated by the construction of Dirichlet process prior in Bayesian nonparametric statistics. The prior assigns weight to each atom according to a GEM distribution, and the simulation algorithm enables us to sample from the N largest random weights of the prior. Then we extend the simulation algorithm to a generalised gamma process. The simulation problem of inhomogeneous processes will also be considered. Numerical implementations are provided to illustrate the effectiveness of our algorithms.
Assessing Inhibitory Control Deficits in Adult ADHD: A Systematic Review and Meta-analysis of the Stop-signal Task
Authors: Senkowski Daniel , Ziegler Theresa , Singh Mervyn , Heinz Andreas , He Jason , Silk Tim , Lorenz Robert C. 
Published: June 2023

Abstract
In recent years, there has been an increasing quest in improving our understanding of the neurocognitive deficits underlying adult attention-deficit/hyperactivity disorder (ADHD). Current statistical manuals of psychiatric disorders emphasize inattention and hyperactivity-impulsivity symptoms, but empirical studies have also shown consistent alterations in inhibitory control. To date, there is no established neuropsychological test to assess inhibitory control deficits in adult ADHD. A common paradigm for assessing response inhibition is the stop-signal task (SST). Following PRISMA-selection criteria, our systematic review and meta-analysis integrated the findings of 26 publications with 27 studies examining the SST in adult ADHD. The meta-analysis, which included 883 patients with adult ADHD and 916 control participants, revealed reliable inhibitory control deficits, as expressed in prolonged SST response times, with a moderate effect size $$g$$
g
= 0.51 (95% CI: 0.376–0.644,$$p$$
p
< 0.0001). The deficits were not moderated by study quality, sample characteristics or clinical parameters, suggesting that they may be a phenotype in this disorder. The analyses of secondary outcome measures revealed greater SST omission errors and reduced go accuracy in patients, indicative of altered sustained attention. However, only few (N < 10) studies were available for these measures. Our meta-analysis suggests that the SST, in conjunction with other tests and questionnaires, could become a valuable tool for assessing inhibitory control deficits in adult ADHD.
A Location-allocation Model for Bio-waste Management in the Hospitality Sector
Authors: Santos-Peñate Dolores R. , Suárez-Vega Rafael R. , de la Nuez Carmen Florido 
Published: June 2023

AbstractTourism generates huge amounts of waste. It has been estimated that about half of the waste generated by hotels is food and garden bio-waste. This bio-waste can be used to make compost and pellets. In turn, pellets can be used as an absorbent material in composters and as an energy source. In this paper, we consider the problem of locating composting and pellet-making facilities so that the bio-waste generated by a chain of hotels can be managed at or close to the generation points. The general objective is twofold: i) to avoid waste transportation from generation to treatment points and product transportation from production to demand points, and ii) to implement a circular model in which the hotels themselves become the suppliers of the products they need (compost and pellets) by transforming the bio-waste that they generate. Any bio-waste not processed by the hotels has to be treated at private or state-run plants. A mathematical optimization model is presented to locate the facilities and allocate the waste and products. The application of the proposed location-allocation model is illustrated with an example.
Opportunities and Challenges to Linkage to Housing in the Context of a Sexual and Reproductive Health Program for Youth Experiencing Homelessness
Authors: Huq Maisha R. , Phillips Danielle R. , Childers Christine , Chavez Rebecca , Tellei Jacqueline , Blakely Lenora , Aparicio Elizabeth M. 
Published: June 2023

AbstractYouth homelessness remains a major public health issue in the USA, and youth experiencing homelessness (YEH) are still one of the more understudied and underserved groups. Comprehensive sexual and reproductive health (SRH) programs for YEH are rare. Yet, such programs are potentially effective settings through which to link YEH with housing services. Wahine (“woman”) Talk is one such comprehensive program for YEH, and is a multilevel intervention delivered out of a youth drop-in center in Honolulu, Hawai ‘i. One of Wahine Talk’s core components is addressing basic needs, including providing linkages to housing services. Little research exists on SRH programs’ opportunities and challenges to providing linkage to housing for YEH. The current study is an exploratory study asking, “What are opportunities and challenges to linking young women experiencing homelessness to housing services through a comprehensive sexual and reproductive health program?” The study team collected in-depth qualitative data through seven focus groups and 25 individual interviews with Wahine Talk staff and youth participants aged 14–22 years. Multiple team members analyzed the data using template analysis. The analysis revealed that while comprehensive SRH programs may have some opportunities and challenges to linking YEH to housing services that are consistent with traditional housing assistance programs, there are also factors specific to SRH programs. In particular, opportunities would be SRH programs employing a housing staff person and bolstering staff-youth meetings and communication. A challenge specific to SRH programs would be prioritizing youth’s reproductive justice (i.e., choice) in lieu of solely prioritizing pregnancy reductions and delays; thus, it is recommended to train staff to prioritize youth’s reproductive justice. The findings highlight the importance of SRH programs having staff focused on housing, sufficient opportunities for youth and staff to communicate with each other, and staff trained to prioritize youth’s reproductive justice.
Proteogenomics of the novel Dehalobacterium formicoaceticum strain EZ94 highlights a key role of methyltransferases during anaerobic dichloromethane degradation
Authors: Wasmund Kenneth , Trueba-Santiso Alba , Vicent Teresa , Adrian Lorenz , Vuilleumier Stéphane , Marco-Urrea Ernest 
Published: June 2023

AbstractDichloromethane (DCM, methylene chloride) is a toxic, high-volume industrial pollutant of long-standing. Anaerobic biodegradation is crucial for its removal from contaminated environments, yet prevailing mechanisms remain unresolved, especially concerning dehalogenation. In this study, we obtained an assembled genome of a novel DCM-degrading strain, Dehalobacterium formicoaceticum strain EZ94, from a stable DCM-degrading consortium, and we analyzed its proteome during degradation of DCM. A gene cluster recently predicted to play a major role in anaerobic DCM catabolism (the mec cassette) was found. Methyltransferases and other proteins encoded by the mec cassette were among the most abundant proteins produced, suggesting their involvement in DCM catabolism. Reductive dehalogenases were not detected. Genes and corresponding proteins for a complete Wood-Ljungdahl pathway, which could enable further metabolism of DCM carbon, were also found. Unlike for the anaerobic DCM degrader “Ca. F. warabiya,” no genes for metabolism of the quaternary amines choline and glycine betaine were identified. This work provides independent and supporting evidence that mec-associated methyltransferases are key to anaerobic DCM metabolism.