bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Window of Hope training module for Ghanaian teacher trainees meet the requirements of UNESCO’s Technical Guidance on Sexuality Education?
Authors: Yakpir Gordon , Atuguba Juliet 
Published: December 2022

The Window of Hope (WoH) training Module was introduced in Ghanaian Colleges of Education (CoE) by the Ministry of Education (MoE) to prepare trainees to teach sexuality education upon completion of their training. Using a document analysis methodology, we compared the processes of developing the WoH module and its content to the international technical guidance framework for teacher training on sexuality education. We found that the WoH module is unlikely to achieve its stated objectives as key components of the technical guidance are not catered to in the module. We recommend a comprehensive review of the content of WoH using the National Teacher Preparation Standards Framework and Ghana’s newly developed teacher training standards. We also recommend, broad consultations involving all interest groups in Ghana in the review process.
An eolian dust origin for clastic fines of Devono-Mississippian mudrocks of the greater North American midcontinent
Authors: McGlannan Austin J. , Bonar Alicia , Pfeifer Lily , Steinig Sebastian , Valdes Paul , Adams Steven , Duarte David , Milad Benmadi , Cullen Andrew , Soreghan Gerilyn S. 
Published: December 2022

ABSTRACTUpper Devonian and Lower–Middle Mississippian strata of the North American midcontinent are ubiquitously fine-grained and silt-rich, comprising both so-called shale as well as argillaceous limestone (or calcareous siltstone) that accumulated in the Laurentian epeiric sea. Although long recognized as recording marine deposition, the origin and transport of the fine-grained siliciclastic material in these units remains enigmatic because they do not connect to any proximal deltaic feeder systems. Here, we present new data on grain size, whole-rock geochemistry, mineralogy, and U-Pb detrital-zircon geochronology from units across Oklahoma; we then integrate these data with models of surface wind circulation, refined paleogeographic reconstructions, and correlations from the greater midcontinent to test the hypothesis that wind transported the siliciclastic fraction to the marine system. The exclusively very fine silt to very fine sand grain size, clear detrital origin, widespread distribution over large regions of the epeiric sea, Appalachian sources, and paleogeographic setting in the subtropical arid belt far-removed from contemporaneous deltaic feeder systems are most consistent with eolian transport of dust lofted from subaerial delta plains of the greater Appalachian orogen and incorporated into subaqueous depositional systems. Delivery of dust that was minimally chemically weathered to Devono-Mississippian epeiric seas likely provided essential nutrients that stimulated organic productivity in these commonly organic-rich units.
The devastating 2022 M6.2 Afghanistan earthquake: challenges, processes and implications
Authors: Kufner Sofia-Katerina , Bie Lidong , Gao Ya-Jian , Lindner Mike , Waizy Hamidullah , Kakar Najibullah , Reitbrock Andreas 
Published: December 2022

Abstract

On June 21th, a Mw6.2 earthquake struck the Afghan-Pakistan-border-region, an area dominated by partitioned deformation related to the India-Asia collision. Despite its moderate size, 1150 deaths were reported, making the event the deadliest earthquake of 2022 so far. We investigate the event’s rupture processes, aiming to understand what made it that fatal. Our InSAR-constrained slip model and regional moment-tensor inversion reveal a sinistral rupture with maximum slip of 1.8 m at 5 km depth on a N20°E striking, sub-vertical fault. Field observations confirm fault location and slip-sense. Based on our analysis and a global comparison, we suggest that not only external factors (e.g. time of the event and building stock) but also fault-specific factors made the event excessively destructive. Surface rupture was favored by the local rock anisotropy (foliation), coinciding with the fault strike. The distribution of Peak Ground Velocity was governed by the sub-vertical fault. The maximum slip was large compared to other events globally and might have resulted in peak-frequencies coinciding with the resonance-frequency of the local one-story buildings. More generally, our study demonstrates the devastating impact of moderate earthquakes, being small enough to be accommodated by many tectonic structures but large enough to cause significant damage.
Assessing Factors Influencing the Effectiveness of Logistics Management Information Systems on Drugs Supply Chain management in Sierra Leone
Authors: Kamara Lamin , Kalinga Ellen Chale 
Published: December 2022

Abstract
Background: Logistics Management Information System (LMIS) was introduced in Sierra Leone to improve drug supply management and provide accurate information that can be used for planning and resources allocation. The system managed drugs supplies, but this system is being influenced by factors to enhance effective drugs supply management.
Methodology: The study examined factors considered to influence LMIS effectiveness on drugs supplies management, using the conceptual framework model. Purposive and sequential exploratory means of data collection through self-administered questionnaires was employed.
Results: The study identified eleven factors and only four (Forecasting, Logistics, Information Quality and Production) have significant influence on LMIS effectiveness on drugs supply management.
Conclusion: The study showed four factors having positive and statistically significant effect on LMIS effectiveness on drugs supply management. Therefore, strengthening these factors would significantly improve LMIS effectiveness on drugs supply management in Sierra Leone.
ATF5 Regulates Tubulointerstitial Injury In Diabetic Kidney Disease Via Mitochndrial Unfolded Protein Response
Authors: Liu Yifei , Zhang Lei , Zhang Shumin , Liu Jialu , Li Xiaohui , Yang Kexin , Yang Danyi , Liu Yu , Sun Lin , Liu Fuyou , Xiao Li 
Published: December 2022

Abstract
Background:Mitochondrial quality control (MQC) plays a critical role in the progression of tubulointerstitial injury in diabetic kidney disease (DKD). Mitochondrial unfolded protein response (UPRmt), an important MQC procedure, is activated to maintain mitochondrial protein homeostasis upon mitochondrial stress. Activating transcription factor 5 (ATF5) has been proved to be the key in mammalian UPRmt via its mitochondria-nuclear translocation. In this study, we investigated whether ATF5 activate UPRmt in mammalian DKD to reduce tubule injury.
Methods: Eight-week-old db/db mice were injected with ATF5-shRNA lentivirus or negative control lentivirus via the tail vein. Mice were euthanized at 12 weeks, DHE and Tunel assay were performed respectively to evaluate the apoptosis and ROS production of kidney section. And we used western blotting to detect the expression relationship between ATF5 and UPRmt. ATF5-siRNA, ATF5 overexpression plasmid or HSP60-siRNA were transfected into HK-2 cells. Mitosox and DCFH-DA staining methods were used to gauging cell and mitochondial oxidative stress level, while early stage of cell apoptosis was detected by JC-1 kit.
Results: We found that UPRmt intensified and exhibited opposite function in HK-2 cells in respond to high glucose intervention. We showed that compared with non-diabetic samples, renal section from patients and mice with diabetes showed increase expression of ATF5 and UPRmt related proteins (HSP60, CLpP, LONP1), which were correlated with tubule damage of kidney. We also established 12-week-old ATF5 knocking-down db/db mice, and found they presented improved biochemical and histological features and lower expression of UPRmt related proteins as compared with db/db mice. Correspondingly, HG-induced oxidative stress damage, apoptosis and UPRmt were reversed by ATF5-siRNA in HK-2 cells and aggravated by ATF5 over-expressing plasmid. Moreover, overexpressing ATF5 and down-regulating HSP60 simultaneously offset the effect of ATF5 overexpressing plasmid.
Conclusions: Our findings suggest that ATF5 is closely associated with the progress of damage in diabetic kidney tubule cells by regulating UPRmt.
Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
Authors: Li Xiangdong , Wang Ziyi , Jiao Chenyu , Zhang Yu , Xia Nan , Yu Wenjie , Chen Xuejiao , Wikana Likalamu Pascalia , Liu Yue , Sun Linfeng , Chen Minhao , Xiao Yuhao , Shi Yuhua , Han Sheng , Pu Liyong 
Published: December 2022

Abstract
Background
Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liver metastasis (CRLM). However, many patients experience CRLM recurrence after the initial liver resection. As an unavoidable pathophysiological process in liver surgery, liver ischemia-reperfusion (IR) injury increases the risk of tumor recurrence and metastasis.
Methods
Colorectal liver metastasis (CRLM) mouse models and mouse liver partial warm ischemia models were constructed. The levels of lipid peroxidation were detected in cells or tissues. Western Blot, qPCR, elisa, immunofluorescence, immunohistochemistry, scanning electron microscope, flow cytometry analysis were conducted to evaluate the changes of multiple signaling pathways during CRLM recurrence under liver ischemia-reperfusion (IR) background, including SGK1/IL-6/STAT3, neutrophil extracellular traps (NETs) formation, polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) infiltration.
Results
Hepatocyte serum/glucocorticoid regulated kinase 1 (SGK1) was activated in response to hepatic ischemia-reperfusion injury to pass hepatocyte STAT3 phosphorylation and serum amyloid A (SAA) hyperactivation signals in CRLM-IR mice, such regulation is dependent on SGK-activated IL-6 autocrine. Administration of the SGK1 inhibitor GSK-650394 further reduced ERK-related neutrophil extracellular traps (NETs) formation and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) infiltration compared with targeting hepatocyte SGK1 alone, thereby alleviating CRLM in the context of IR.
Conclusions
Our study demonstrates that hepatocyte and immune cell SGK1 synergistically promote postoperative CRLM recurrence in response to hepatic IR stress, and identifies SGK1 as a translational target that may improve postoperative CRLM recurrence.
Study protocol for a multicenter, multinational, observational registry of epidemiology, treatment and outcome of patients with Robin Sequence
Authors: Oechsle Anna-Lisa , Wiechers Cornelia , Abadie Veronique , Abel Francois , Breugem Corstiaan , Poets Christian F. 
Published: December 2022

Abstract
Background: Robin sequence (RS) is a congenital condition characterized by micrognathia, glossoptosis, and upper airway obstruction. Diagnosis and treatment are characterized by heterogeneity, resulting in a lack of uniformly collected data.
Methods: We have set up a prospective, observational, multicenter, multinational registry aimed at obtaining routine clinical data from RS patients receiving different treatment approaches and enabling an assessment of outcomes obtained through different therapeutic approaches. Patient enrollment has started in January 2022. Disease characteristics, adverse events, and complications depending on the different diagnostic and treatment approaches and their effects on neurocognition, growth, speech development, and hearing outcome are evaluated using routine clinical data. In addition to characterizing the patient population and comparing outcomes achieved with different treatment approaches, the registry will evolve to focus on endpoints such as quality of life and long-term developmental status.
Discussion: This registry will provide data on different treatment approaches collected during routine care with diverse framework conditions and will allow assessing diagnostic and therapeutic outcomes of children with RS. These data, urgently demanded by the scientific community, will increase the quality of the different therapeutic approaches and knowledge about the long-term outcome of children born with this rare condition.
Trial registration: DRKS00025365
A Note on Hilbert's ``Geometric'' Tenth Problem
Authors: Tyrrell Brian 
Published: December 2022

Abstract
This paper explores undecidability in theories of positive characteristic function fields in the “geometric” language of rings LF = {0, 1,+, ·, F}, with a unary predicate F for nonconstant elements. We indicate how to generalise existing machinery to prove the undecidability of the ∀1∃+-LF theory (without parameters) of any function field of a curve over an algebraic extension of Fp, not algebraically closed. We discuss the problem (and its geometric implications) further in this context too.
MSC Classification: 03B25 , 12L05
Incidence and risk factors for development of cardiac toxicity in adult patients with newly diagnosed acute myeloid leukemia
Authors: Boluda Blanca , Solana-Altabella Antonio , Cano Isabel , Martinez-Cuadron David , Acuña-Cruz Evelyn , Torres-Miñana Laura , Rodriguez-Veiga Rebeca , Navarro-Vicente Irene , Martínez-Campuzano David , García-Ruiz Raquel , Lloret Pilar , Asensi Pedro , Osa-Saez Ana , Aguero Jaume , Rodríguez-Serrano Maria , Buendía-Fuentes Francisco , Megías-Vericat Juan Eduardo , Martín-Herreros Beatriz , Barragan Eva , Sargas Claudia , Salas Maribel , Wooddell Margaret , Dharmani Charles , Sanz Miguel , Rubia Javier de la , Montesinos Pau 
Published: December 2022

Abstract
The incidence of cardiac morbi-mortality in acute myeloid leukemia (AML) is not well known. We aim to estimate the cumulative incidence (CI) of cardiac events in AML patients (pts) and to identify risk factors for their occurrence. Among 571 newly diagnosed AML pts, 26 (4.6%) developed fatal cardiac events and 19 (3.6%) among 525 treated pts (CI: 2% at 6 months; 6.7% at 9 years). Prior heart disease was associated with development of fatal cardiac events [Hazard Ratio (HR) = 1.9]. The CI of non-fatal cardiac events was 43.7% at 6 months and 56.9% at 9 years. Age ≥ 65 (HR = 2.2), relevant cardiac antecedents (HR = 1.4) and non-intensive chemotherapy (HR = 1.8) were associated with non-fatal cardiac events. The 9-years CI of grade 1–2 QTcF prolongation was 11.2%, grade 3 was 2.7%, and no patient had grade 4–5 event. The 9-years CI of grade 1–2 cardiac failure was 1.3%, grade 3–4 was 15%, and grade 5 2.1%; of grade 1–2 arrhythmia was 1.9%, grade 3–4 was 9.1%, and grade 5 1%. Among 285 intensive therapy pts, median overall survival decreased in those experiencing grade 3–4 cardiac events (p < 0.001). We observed a high incidence of cardiac toxicity associated with significant mortality in AML.
Breaking free from field layers: the interest of Post-Excavation Stratigraphies (PES) for producing reliable archaeological interpretations and increasing chronological resolution
Authors: Discamps Emmanuel , Thomas Marc , Dancette Christelle , Gravina Brad , Plutniak Sébastien , Royer Aurélien , Angelin Alexandre , Bachellerie François , Beauval Cédric , Bordes Jean-Guillaume , Deschamps Marianne , Ducasse Sylvain , Langlais Mathieu , Laroulandie Véronique , Mallye Jean-Baptiste , Michel Alexandre , Perrin Thomas , Rendu William 
Published: December 2022

Abstract
In order to track diachronic changes in archaeological sequences, researchers typically partition time into stratigraphic layers defined during fieldwork, which serve as the framework for ensuing analyses. These analytical units have a significant impact on archaeological inference, defining its resolution, and influencing both the study of cultural assemblages and the reconstruction of past environments. However, field layers are seldom re-evaluated after excavation despite the fact that archaeological deposits are now commonly recognised as often containing material ‘mixed’ together by site formation processes, excavation techniques or analytical practices. Although the analysis of intra-site spatial data clearly offers a means to overcome these issues, our literature review of 192 journal articles revealed the potential of this data (notably vertical projections of piece-plotted artefacts) to be under-exploited in Prehistoric archaeology. Here we advocate for the development of a more spatially-informed framework for interpretation that we refer to as Post-Excavation Stratigraphies or PES. After proposing a definition for “PES”, we attempt to develop a framework for theoretical considerations underlying their implication, importance, and potential. Three main benefits of PES are highlighted: ensuring assemblage reliability, increased chronological and spatial resolution, and more reliable interpretations based on a multi-stratigraphic approach. We contend that the stratigraphy defined during fieldwork is insufficient and potentially misleading. By providing a different “stratigraphic view” of the same sequence, each specialist can contribute data that, when combined, produces a better understanding of interactions between changes in, for example, technological or cultural traditions, subsistence strategies, or paleoenvironments.
Python Based User Interactive Voice Bot
Authors: Khare Akshay 
Published: December 2022

In this paper, a python-based voice bot is proposed which is able to give answers to any question of the user and it should be able to follow commands of the user. AI is the main area of creating intelligent machines, particularly computer programs. It is related to the well-known task of employing computers to comprehend human intelligence. This paper provides an outline of the concept of a personal assistant for Windows-based platforms. The system is inspired by virtual assistants such as Siri for iOS and Cortana for Windows. It has been intended for performing a variety of operations by utilizing well-defined commands. This work focuses on assisting end-users with day-to-day activities such as searching questions on Google, general conversation with the user, searching for YouTube or other websites, automatic keyboard and mouse handling, sending mail, mathematical calculations, opening applications and files on the PC, clicking photos, and many more tasks. Machine learning is used to assess user statements/commands to provide the best solution.
Analysis of somatometric parameters of children with recurrent subluxations of C1–C2 vertebrae
Authors: Fedorova E. P. , Kuzmin V. N. , Goncharova L. A. , Tanyushcheva N. Yu. , Kurkin A. M. , Alimusaeva M. R. 
Published: December 2022

Introduction. The problem of instability in the cervical spine in children has been repeatedly discussed in the medical literature and has become the subject of discussion. This is due to a significant increase in the number and recurrence of subluxations in the C1–C2 segment. An assumption is made about the relationship of this pathology with systemic connective tissue dysplasia, but evidence-based studies are required.Aim. To make a statistical analysis of individual somatometric indicators in children with recurrent subluxations of the C1–C2 vertebrae and signs of connective tissue dysplasia.Materials and methods. The analysis of measurements of selected body parameters in pre-pubertal children with acute and recurrent torticollis against the background of systemic connective tissue dysplasia was carried out. The data of 186 children aged 9–11 years in comparative groups for the period 2016–2021 were studied. Modern methods of statistics were used.Results. Dependences were obtained confirming the hypothesis of the relationship between asthenic physique (high height, low weight and chest circumference) and recurrent dislocations in the C1–C2 segmentConclusions. When comparing the average values for two independent samples made up of the indicators of the main group and the comparison group, the conclusion obtained during visual examination and somatometric examination of patients diagnosed with torticollis at admission to the hospital was confirmed: relapses are inherent in children with high growth, low weight, smaller chest circumference and smaller wrist circumference.
Experience with the use of immunobiological drugs in the treatment of patients with severe bronchial asthma and comorbidities
Authors: Sereda V. P. , Svirido D. A. , Komarov M. V. , Smulskaya O. A. 
Published: December 2022

Introduction. The accumulation of clinical experience in the use of biological therapy in patients with severe bronchial asthma (SBA) in real-world clinical practice with the possible identification of additional, previously undescribed clinical results is of practical interest.Aim. The goal of the study is to present results of observational study that reflects experience of using benralizumab in SBA in real-world clinical practice in city of Saint Petersburg.Materials and methods. We presents results of more than 1 year observation of 18 patients with eosinophilic SBA (12 females, 6 males, age from 28 to 74, average age 55 ± 11.9 years). Patients received benralizumab in addition to standard medical management. Conducted clinical, laboratory, functional examination of patients, assessment of the frequency of exacerbations and additional clinical effects.Results. It was shown that the inclusion of benralizumab in complex therapy led to a significant improvement in disease control, improved bronchial conduction, a significant decrease in blood eosinophilia and a reduction in the number of exacerbations. Clinical examples are given that evidence to the stabilizing effect of this therapy on the course of recurrent nasal polyposis and the positive effects on the course of eosinophilic granulomatous polyangiitis, manifested by SBA.Conclusions. In real clinical practice, the possibility of a significant improvement in control in patients with SBA with the use of biological therapy has been confirmed. At the same time, data have been obtained that will allow expanding the indications for the use of benralizumab in the future.
Genetic markers of the risk of fetal growth retardation in pregnant women with preeclampsia
Authors: Abramova M. Yu. , Ponomarenko I. V. , Orlova V. S. , Batlutskaya I. V. , Efremova O. A. , Sorokina I. N. , Churnosov M. I. 
Published: December 2022

Introduction. Preeclampsia (PE) and fetal growth retardation (FGR), the main mechanism of which is the pathology of the placenta, directly affect the structure of both maternal and perinatal morbidity and mortality, which determines the medical and social significance of the study of PE and FGR, especially genetic predictors of the development of these complications of gestation. Objective. To study the involvement of GWAS polymorphism of significant arterial hypertension candidate genes in the formation of FGR in pregnant women with PE. Materials and methods. The samples for the study included 83 pregnant women with PE in combination with FGR and 369 women with isolated PE who were included in the control group. All women underwent a molecular genetic study of four polymorphisms: rs932764 PLCE1, rs167479 RGL3, rs633185 ARHGAP42, rs7302981 CERS5, and studied their relationship with the development of FGR in pregnant women with PE. The functional effects of polymorphic markers, which showed significant associations with the formation of FGR in pregnant women with PE, were examined using international bioinformatic projects on functional genomics (HaploReg, GTExportal, PolyPhen-2). Results and discussion. The AA genotype of the rs9327643 locus of the PLCE1 gene significantly reduces the risk of FGR formation in pregnant women with PE according to the recessive model (OR = 0.37; p = 0.01; pperm = 0.01). The rs932764 polymorphic variant of the PLCE1 gene is located in the region of regulatory DNA motifs for 2 Hdx and Zic transcription factors, localized in the region of histone protein encoding H3K4me1 enhancers in the brain and associated with the expression of the HDAC1P1 gene in male gonad tissues. Conclusions. The polymorphic locus rs9327643 of the PLCE1 gene is associated with the risk of developing FGR in pregnant women with PE.