bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Insights and Global Trends in the Relationship between Selenium
and Thyroid Diseases: A Bibliometric Analysis
Authors: Wu Yuqing , Cai Tiantian , Tao Yuan , Zhao Jing , Zhang Jinan 
Published: September 2023

Objective:
Selenium, a significant trace element needed by the human body, is closely
related to thyroid. Therefore, this study aimed to explore the status of selenium and thyroid diseases,
analyze emerging insights, and predict future trends.

Methods:
Literature on selenium and thyroid included in the core database of Web of Science
from January 1992 to October 2022 was retrieved. CiteSpace and VOSviewer software were used
for visual analysis in terms of publication, author, country, institution, co-citation, and keywords.

Results:
A total of 1,142 works of literature were included after the screening, and the annual publication
showed a fluctuating upward trend. The country and the institution with the highest publication
volume were the United States and Charité Universitätsmedizin Berlin, respectively. In
terms of authors, Schomburg L has formed a cooperative network and has published the largest
number of papers and made great contributions in this field. The biggest cluster of keywords was
trace elements, and the hot keywords in recent years were oxidative stress, Hashimoto's thyroiditis,
cadmium, copper, etc.

Conclusion:
This paper analyzes the current status, insights, and trends of the studies on selenium
and thyroid diseases by the method of bibliometrics and delivers ideas and methods for subsequent
research in this field. The therapeutic effect of selenium on Hashimoto's thyroiditis is controversial
and needs further research, and oxidative stress is also a research hotspot in this field. The crossstudy
of multiple trace elements and diseases may be the development trend in the future.
PF-04449913 Inhibits Proliferation and Metastasis of Colorectal Cancer Cells by
Down-regulating MMP9 Expression through the ERK/p65 Pathway
Authors: Ruan Yejiao , Lu Guangrong , Yu Yaojun , Luo Yue , Wu Hao , Shen Yating , Gao Zejun , Shen Yao , Cai Zhenzhai , Li Liyi 
Published: September 2023

Introduction:
Colorectal cancer remains a life-threatening malignancy with increasing morbidity and mortality worldwide. Therefore, new and effective anti-colorectal cancer therapeutics are urgently needed.

Methods:
In this study, we have studied the anti-tumor properties and potential mechanisms of PF-04449913. Colorectal cancer cell viability was reduced by PF-04449913 in a dose-dependent manner. The migration and invasion ability of malignant colon cells were attenuated by the drug, as demonstrated by the Transwell test. Moreover, PF-04449913 repressed the phosphorylation levels of ERK and other proteins, and the expression levels of MMP9. The anti-tumor effects of the drug in vivo were demonstrated in BALB/c-nude mice models, and PF-04449913 inhibited the malignant phenotype of colorectal cancer cells, including reduction of tumor size and promotion of apoptosis. At the molecular level, PF-04449913 induced a significant decrease in ERK and p65 protein phosphorylation levels and inhibited MMP9 protein expression.

Results:
Both in vivo and in vitro results showed PF-04449913 to demonstrate antitumor effects, which have been proposed to be mediated through blockade of the ERK/p65 signaling pathway, and subsequent repression of MMP9 expression.

Conclusion:
Our study provides a new perspective on the potential clinical application of PF-04449913 in the treatment of colorectal cancer.
Hemorrhoid (Pile) and its Treatment with Botanicals: An Overview
Authors: Shukla Ajay Kumar , Mishra Manoj Kumar 
Published: September 2023

:
Hemorrhoid disease is a common condition that can have a significant impact on an individual's
quality of life due to its associated symptoms. A wide range of management options are
available for the treatment of hemorrhoid disease, including various yogic kriyas, herbal remedies,
flavonoids, tocotrienols, topical treatments, hydrotherapy, dietary approaches, and surgical procedures.
This review aims to focus specifically on the use of botanicals for the treatment of hemorrhoid
disease, covering various aspects of its treatment.
MASI, a Smartphone App to Improve Treatment Adherence Among South African Adolescents and Young Adults With HIV: Protocol for a Pilot Randomized Controlled Trial
Authors: Mulawa Marta I , Hoare Jacqueline , Knippler Elizabeth T , Mtukushe Bulelwa , Matiwane Mluleki , Muessig Kathryn E , Al-Mujtaba Maryam , Wilkinson T Harper , Platt Alyssa , Egger Joseph R , Hightow-Weidman Lisa B 
Published: September 2023

Background
Adolescents and young adults with HIV repeatedly demonstrate low rates of antiretroviral therapy (ART) adherence as well as low rates of viral suppression. Digital health interventions are a promising way to engage adolescents and young adults with HIV to support ART adherence. However, few digital health interventions have been developed and tested with adolescents and young adults in countries like South Africa, where the HIV burden among adolescents and young adults is greatest. Masakhane Siphucule Impilo Yethu (MASI; Xhosa for “Let's empower each other and improve our health”) is a comprehensive ART adherence-supporting app for South African adolescents and young adults with HIV. It was culturally adapted using the HealthMpowerment platform.

Objective
The aim of this paper is to describe the protocol for a pilot randomized controlled trial examining the feasibility, acceptability, and preliminary efficacy of MASI on self-reported ART adherence and social support.

Methods
We will enroll 50 adolescents and young adults with HIV ages 15-21 years. Participants will be recruited from public ART clinics linked to a large government-funded teaching hospital in Cape Town, South Africa. Participants will be randomized 1:1 into either the intervention arm receiving a full version of MASI or the control arm receiving an information-only version of the app (n=25 per arm). Participants will be asked to engage with MASI daily for 6 months. All participants will complete baseline and follow-up assessments at 3 and 6 months.

Results
Study screening began in May 2022 and the first participant was enrolled on June 21, 2022. As of June 12, 2023, 81 participants have completed screeners, and 36 eligible participants have been enrolled in the pilot randomized controlled trial. Recruitment is anticipated to last through August 31, 2023, with study activities anticipated through February 29, 2024.

Conclusions
There is an urgent need for innovative interventions to improve ART adherence among adolescents and young adults in settings like South Africa. If found to be feasible and acceptable, MASI could be implemented with adolescents and young adults with HIV in other parts of the country.

Trial Registration
ClinicalTrials.gov NCT04661878; https://clinicaltrials.gov/ct2/show/study/NCT04661878

International Registered Report Identifier (IRRID)
DERR1-10.2196/47137
Perilaku Seksual Berisiko serta Kaitannya dengan Keyakinan Diri Remaja untuk Mencegah: Studi Deskriptif
Authors: Simak Valen Fridolin , Kristamuliana Kristamuliana , Sekeon Crista Gretasia 
Published: September 2023

Background: The misuse of media or technology (smartphones, internet) to access various information including pornographic sites can increase adolescents to engage in sexual activity because adolescents continue to feel challenged to do so in real life.Objective: Describe risky sexual behavior and its relation to adolescent self-efficacy to prevent itMethod: The method used in this research is descriptive analytic conducted online by distributing questionnaire links to prospective respondents. The data analysis process used the Pearson testResults and Discussion: There is an increase in the number of incidents of risky sexual behavior, 39% of adolescents are not at risk, 8.1% are low risk, 27.7% are at moderate risk and 25.2% are at high risk. The majority of adolescents have the confidence to prevent risky sexual behavior by 64.8%. Furthermore, the results found that there was a significant relationship between risky sexual behavior and adolescent self- efficacy with a p value of 0.005.Conclusion: The increasing number of cases of risky sexual behavior can be of particular concern for all of us, especially health workers, to be able to develop educational program methods for adolescents, considering that this age is the nation's successor. Keywords: adolescent; risky sexual behavior; self- efficacy
Perbandingan Efek antara Pemberian Nifedipin dan Salbutamol sebagai Tokolitik pada Ibu Hamil dengan Ancaman Persalinan Prematur
Authors: Irwan Andi Alamanda , Kabo Peter , Wahyudi Elly , Mappaware Nasrudin Andi , Djabir Yulia Yusrini 
Published: September 2023

Latar belakang: Ancaman persalinan prematur dapat terjadi pada usia kehamilan 22 – 37 minggu. Hal ini menjadi penyebab meningkatnya angka kematian dan kesakitan pada neonatus/bayi masih sangat tinggi di beberapa negara. Salah satu upaya yang dilakukan untuk mencegah kelahiran prematur pemberian tokolitik.Objektif: Penelitian ini bertujuan untuk mengetahui perbandingan efek antara Nifedipin dan Salbutamol sebagai tokolitik pada ibu hamil dengan ancaman persalinan prematur.Metode: Desain penelitian adalah cross sectional dengan metode simple random sampling. Hasil dan Pembahasan: Sampel terdiri dari 20 kelompok Nifedipin dan 20 kelompok Salbutamol. Analisis bivariat digunakan untuk menilai hubungan antara efek pemberian obat tokolitik terhadap kontraksi. Hasil menunjukan nilai yang signifikan (p=0,000) pada semua sampel, dimana mengalami penurunan kontraksi setelah diberikan nifedipin dan salbutamol. Hal ini sesuai dengan teori tentang mekanisme kerja tokolitik yang menghambat kontraksi otot polos.Kesimpulan: Nifedipin dan Salbutamol efektif dalam mencegah kontraksi pada ancaman persalinan prematur. Efek samping ditemukan pada penggunaan Nifedipin.Kata Kunci: Tokolitik, Nifedipin, Salbutamol, Ibu Hamil, Kardiotokografi
Penerapan Robert Buckman's Six-step Protocol pada Kehamilan dengan Kanker Ovarium
Authors: Darmayasa I Made , Sugiharta Amelia Dwi Nurulita , Siahaan Sarah Endang S 
Published: September 2023

Latar Belakang: Penyampaian berita buruk merupakan salah satu materi penting dalam ketrampilan komunikasi medis. Diperlukan pendekatan khusus dalam penyampaian informasi medis yang dapat menimbulkan respon buruk. Diagnosis kanker ovarium sendiri disertai kehamilan yang tidak direncanakan merupakan berita buruk yang sangat stress full, apalagi akan dilakukan terminasi kehamilan. Diperlukan protokol yang bisa dijadikan panduan untuk menyampaikannya kepada pasien.Tujuan: Untuk mempelajari dan menerapkan Robert Buckman's Six-step Protocol dalam menyampaikan satu laporan kasus berita medis yang buruk (medical breaking bad news) yang dialami seorang perempuan yang menderita kanker ovarium dan hamil, serta akan dilakukan terminasi kehamilan.Metode: Sebuah laporan kasus tentang penderita Kanker Ovarium, hamil tanpa perencanaan dan akan dilakukan terminasi.Hasil dan Pembahasan: Pada saat dilakukan pendekatan klinik dengan diagnosis multiaxial, pada axis I didapatkan penderita dengan Gangguan Penyesuaian dengan Reaksi Campuran Cemas (F32.2), pada axis II dtemukan adanya ciri kepribadian cemas, MPE acting out, dan displacement. Pada axis III pasien hamil ketiga usia kehamilan 16 Minggu + Kista Ovarium curiga Ganas. Pada axis IV, pasien harus menghadapi masalah dengan penyakitnya disertai adanya kehamilan. Serta pada avis V Global Assessment of Functioning didapatkan 61-50 sedangakan Global Assessment of Functioning 1 tahun terakhir 90-81. Diterapkan Robert Buckman's Six-step Protocol sebagai panduan dalam menyampaikan informasi buruk tersebut.Kesimpulan: Pasien-pasien kanker ovarium dengan kehamilan yang tidak direncanakan dan akan dilakukan terminasi kehamilan merupakan kelainan medis yang berat dapat diikuti dengan kecemasan dan depresi. Perlu pendekatan khusus mulai dari penyampaian informasi/diagnosis, rencana tindakan dan menghadapi risiko maupun komplikasi yang mungkin dapat terjadi. Terhadap kecemasan dan depresi yang tetap muncul, dilakukan terapi farmakologis dan dikombinasikan dengan non-farmakologi seperti Mindfulness-based cognitive behavioral therapy, dan cognitive behavior therapy. Kata kunci: Robert Buckman's Six-step Protocol; kehamilan tidak direncanakan; kanker ovarium
Luaran Maternal pada Ibu Hamil dengan Covid-19 di Daerah Istimewa Yogyakarta Studi Kohort Retrospektif
Authors: Wahyuningtyas Utami Kartika , Taufiqur Rachman Irwan , Siti Nurdiati Detty 
Published: September 2023

Background: Coronavirus is a disease at the end of 2019 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which now was declared a pandemic by WHO on March 11, 2020. Indonesia reported the first case of COVID-19 on March 2, 2020 and the number still increase until now. The studies of SARS-CoV-2 infection on pregnancy and maternal outcomes are still uncertain since evidence regarding the disease is still ongoing. Moreover, the pregnant women have a higher risk of morbidity and mortality than the general population.Objective: This study aimed to determined the relationship among COVID-19 in pregnancy with maternal outcome at YogyakartaMethods: This is a retrospective cohort study. The subjects were pregnant women who were diagnosed confirm COVID-19. The research subjects were taken at Dr. Sardjito Hospital and Akademik UGM Hospital from March 2020 to August 2021.Results and Discussion: Among all 436 research subjects, obtained 340 sampels that met the criteria for analysis. The characteristics of subjects showed patients with aged >35 years (58.24%), and gestational age ≥37 weeks (79.41%). There were correlated significantly between confirmed symptomatic COVID-19 in pregnant women with prematurity (RR 2,42, CI 95% 1,44–4.04), requiring ICU (RR 53.89, CI 95% 3.33–870.45), length of stay (RR 1.97, CI 95% 1,05–3,68), and maternal mortality maternal (RR 38.08, CI 95% 2,34–619,83) compared with asymptomatic COVID-19. There was no correlated significantly (p>0.05) between COVID-19 in pregnancy with mode of delivery. Age, obesity, hypertension and diabetes mellitus have no correlated significantly with maternal outcomesConclusion: Pregnancy as an independent risk factor for symptomatic COVID-19 that is likely independent of other comorbidities. Pregnant women who symptomatic COVID-19 increase the risk of worse maternal outcome compare with asymptomatic COVID-19. The mode of delivery decided based on medical and obstetric indication. Keywords : COVID-19; pregnancy; co-morbidities; maternal outcomes
Perbandingan Kadar Vitamin D antara Wanita dengan Surgical Menopause Post Kemoterapi dan Wanita Menopause Alami di Yogyakarta
Authors: Pratiwi Rosinta , Dewanto Agung , Kusumanto Ardhanu 
Published: September 2023

Latar Belakang: Menopause merupakan periode berhentinya haid akibat penurunan produksi hormon pada wanita. Menopause dapat terjadi secara alami maupun karena prosedur medis pengangkatan kedua ovarium mau sebab lainnya seperti obat-obatan. Wanita yang mengalami menopause dini karena surgical menopause akan mengeluhkan gejala menopause yang lebih berat karena perubahan hormon secara mendadak. Pasien dengan surgical menopause akibat kanker seringkali mendapatkan kemoterapi adjuvant yang akan menyebabkan penurunan kadar vitamin D, dimana vitamin D diketahui berperan penting dalam mengurangi keluhan menopause. Tujuan: Mengetahui perbandingan kadar vitamin D pada pasien surgical menopause post kemoterapi dan wanita menopause alami. Latar Belakang: Menopause merupakan periode berhentinya haid akibat penurunan produksi hormon pada wanita. Menopause dapat terjadi secara alami maupun karena prosedur medis pengangkatan kedua ovarium mau sebab lainnya seperti obat-obatan. Wanita yang mengalami menopause dini karena surgical menopause akan mengeluhkan gejala menopause yang lebih berat karena perubahan hormon secara mendadak. Pasien dengan surgical menopause akibat kanker seringkali mendapatkan kemoterapi adjuvant yang akan menyebabkan penurunan kadar vitamin D, dimana vitamin D diketahui berperan penting dalam mengurangi keluhan menopause. Tujuan: Mengetahui perbandingan kadar vitamin D pada pasien surgical menopause post kemoterapi dan wanita menopause alami. Metode: Penelitian analitik dengan desain kohort retrospektif untuk membandingkan kadar vitamin D antara 2 kelompok, yaitu kelompok wanita dengan surgical menopause yang sudah dikemoterapi dan wanita post menopause alami. Penilaian kadar vitamin D dilakukan pada satu sampai dua tahun pada kelompok pasca ooforektomi bilateral dan satu sampai dua tahun pasca haid terakhir pada kelompok menopause alami. Perbandingan rerata kadar vitamin D antar 2 kelompok dilakukan dengan uji statistika komparatif menggunakan Independent T-Test. Hasil dan Pembahasan: Rerata dan standar deviasi kadar vitamin D pada kelompok surgical menopause post kemoterapi adalah 14,07 + 5,49 ng/mL sedangkan kelompok menopause alami adalah 17,30 ± 6,92 ng/mL dengan nilai p=0,167. Kesimpulan: Tidak terdapat perbedaan signifikan pada rerata kadar vitamin D antara kelompok surgical menopause post kemoterapi dan post menopause alami.Kata Kunci: surgical menopause; menopause alami; ooforektomi bilateral; vitamin D.
Microbial-Derived Uremic Toxins: Role in the Pathogenesis of Comorbidities in Patients with Chronic Kidney Disease
Authors: Pyatchenkov M. O. , Vlasov A. A. , Sherbakov E. V. , Salikova S. P. 
Published: September 2023

Аim: to analyze the significance of microbial-derived uremic toxins (MDUT) in the pathogenesis of comorbidities in patients with chronic kidney disease (CKD).Key findings. Increased excretion of nitrogen metabolism products into the intestines of patients with CKD is associated with uremic dysbiosis; changes in the metabolic activity of the gut microbiota and the leaky gut syndrome; which largely cause the accumulation of MDUT in the internal environment of the body: indoxyl sulfate; p-cresyl sulfate; trimethylamine-N-oxide; etc. The results of recent studies allow to consider these metabolites as an independent risk factor for adverse outcomes in people with CKD due to the progression of renal dysfunction to the terminal stage; as well as frequent cardiovascular; neurological; bone mineral; nutritional and other complications.Conclusion. MDUT are one of the key modulators of the pathogenetic relationship between the gut and kidneys. Therapeutic manipulations with intestinal microbiota can be considered a promising strategy for preventing complications associated with uremia.
Hermeneutic as a Means of Sustaining Peace
Authors: Olayinka Akintayo Sunday 
Published: September 2023

This paper presents the roles the interpretations of religion (or texts)
and understanding of religion play in the sustainability of peace among
the Yorùbá people of southwest Nigeria. The Yorùbá’s way of interacting
and practising religion has remained moderately amiable over the last
two centuries when compared with other communities in Nigeria. With
attention on Yorùbá Christians and Muslims, this author examines some
specific religious concepts and values that have been useful in guiding
the two religions to retain their peace or return to dialogue table to
refrain from violence and keep the peace. The paper argues that the
interpretations of some religious terms and values among the Yorùbá
enhance their pursuance of peace.
Please note: The bulk of this article is taken from chapter 8
of the author’s doctoral dissertation with a few amendments to suit this
journal.
A Maternal Western-Style Diet Impairs Skeletal Muscle Lipid Metabolism in Adolescent Japanese Macaques
Authors: Greyslak Keenan T. , Hetrick Byron , Bergman Bryan C. , Dean Tyler A. , Wesolowski Stephanie R. , Gannon Maureen , Schenk Simon , Sullivan Elinor L. , Aagaard Kjersti M. , Kievit Paul , Chicco Adam J. , Friedman Jacob E. , McCurdy Carrie E. 
Published: September 2023

Maternal consumption of a Western-style diet (mWD) during pregnancy alters fatty acid metabolism and reduces insulin sensitivity in fetal skeletal muscle. The long-term impact of these fetal adaptations and the pathways underlying disordered lipid metabolism are incompletely understood. Therefore, we tested whether a mWD chronically fed to lean, insulin-sensitive adult Japanese macaques throughout pregnancy and lactation would impact skeletal muscle oxidative capacity and lipid metabolism in adolescent offspring fed a postweaning (pw) Western-style diet (WD) or control diet (CD). Although body weight was not different, retroperitoneal fat mass and subscapular skinfold thickness were significantly higher in pwWD offspring consistent with elevated fasting insulin and glucose. Maximal complex I (CI)-dependent respiration in muscle was lower in mWD offspring in the presence of fatty acids, suggesting that mWD impacts muscle integration of lipid with nonlipid oxidation. Abundance of all five oxidative phosphorylation complexes and VDAC, but not ETF/ETFDH, were reduced with mWD, partially explaining the lower respiratory capacity with lipids. Muscle triglycerides increased with pwWD; however, the fold increase in lipid saturation, 1,2-diacylglycerides, and C18 ceramide compared between pwCD and pwWD was greatest in mWD offspring. Reductions in CI abundance and VDAC correlated with reduced markers of oxidative stress, suggesting that these reductions may be an early-life adaptation to mWD to mitigate excess reactive oxygen species. Altogether, mWD, independent of maternal obesity or insulin resistance, results in sustained metabolic reprogramming in offspring muscle despite a healthy diet intervention.

Article Highlights
In lean, active adolescent offspring, a postweaning Western-style diet (pwWD) leads to shifts in body fat distribution that are associated with poorer insulin sensitivity. Fatty acid–linked oxidative metabolism was reduced in skeletal muscles from offspring exposed to maternal Western-style diet (mWD) even when weaned to a healthy control diet for years. Reduced oxidative phosphorylation complex I–V and VDAC1 abundance partially explain decreased skeletal muscle respiration in mWD offspring. Prior exposure to mWD results in greater fold increase with pwWD in saturated lipids and bioactive lipid molecules (i.e. ceramide and sphingomyelin) associated with insulin resistance.