bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Canadian Longitudinal Study on Aging: A Vehicle for Research on Aging in Older Veterans
Authors: Wolfson Christina , Gauvin Danielle E , Schulz Juliana , Magalhaes Sandra , Tansey Catherine M , Feinstein Anthony , Aiken Alice , Scarfo Brittany , Middleton Jason , Raina Parminder , VanTil Linda , Molnar-Szakacs Istvan 
Published: February 2023

ABSTRACT

Introduction
Research on the health of older Veterans in Canada is an emerging area. Few population-based studies in Canada have included older Veterans as a specific group of interest. This paper describes a cohort of self-identified Veterans within the Canadian Longitudinal Study on Aging (CLSA).

Materials and Methods
Using data from the CLSA baseline assessment (2011-2015), we describe sociodemographic and health characteristics along with military-related variables in a cohort of Veterans in Canada. We also estimate the number of Canadian and non-Canadian Veterans living in Canada at the time of the CLSA baseline data collection.

Results
We estimate that at the CLSA baseline, there were 718,893 (95% confidence interval [CI], 680,033-757,110) Canadian Veterans and 185,548 (95% CI, 165,713-205,100) non-Canadian Veterans aged 45-85 years living in Canada. Veterans were older and predominantly male compared to non-Veterans in the CLSA. Following age and sex adjustment, the distribution of sociodemographic and health characteristics was similar across all groups. The majority (&gt; 85%) of participants in each comparison group reported self-rated general and mental health as excellent, very good, or good. Following age and sex adjustment, most characteristics across groups remained similar. One exception was mental health, where a greater proportion of Veterans screened positive for depression and anxiety relative to non-Veterans.

Conclusions
Using CLSA baseline data, we estimate the number of older Veterans in Canada and present descriptive data that highlight interesting differences and similarities between Veterans and non-Veterans living in Canada. Canadian and non-Canadian Veterans in the CLSA are presented separately, with the latter group having not been previously studied in Canada. This paper presents a snapshot of a cohort of self-identified Veterans within the CLSA at study baseline and highlights the potential of the CLSA as a vehicle for studying the aging Veteran population in Canada for years to come.
Multiplane lensing in wave optics
Authors: Feldbrugge Job 
Published: February 2023

ABSTRACT
Wave effects in lensing form a rich phenomenon at the intersection of classical caustic singularities and quantum interference, yet are notoriously difficult to model. Due to a large number of recently observed pulsars and fast radio bursts in radio astronomy and the prospected increase in sensitivity of gravitational wave detectors, wave effects have already been observed in plasma lensing and will be observed in gravitational lensing in the near future. The interference fringes are sensitive to physical parameters, which cannot be inferred from geometric optics. In particular, for multiplane lensing, the pattern depends on the redshifts of the lens planes. I present a new method to define and efficiently evaluate multiplane lensing of coherent electromagnetic waves by plasmas and gravitational lenses in polynomial time. This method will allow the use of radio and gravitational-wave sources to probe our universe in novel ways.
Copper-induced aggregation of IgG: a potential driving force for the formation of circulating protein aggregates
Authors: Saporito-Magriña Christian , Facio María Laura , Lopez-Montañana Lila , Pagano Guadalupe , Repetto Marisa Gabriela 
Published: February 2023

Abstract
Copper is a highly reactive element involved in a myriad of biological reactions. Thus, while essential for mammalian cells, its concentrations must be kept in check in order to avoid toxicity. This metal participates in redox reactions and may exacerbate oxidative stress in aerobic organisms. Nonetheless, the actual driving force of copper-induced cell death is yet unknown. Likely, free copper ions may target different biomolecules that are crucial for the proper functioning of an organism. In this work, we show that free copper induces protein aggregation in serum. The wide set of proteins present in these biological samples are not equally prone to copper-induced aggregation and some, such as albumin, are highly resistant, whereas γ-globulins are highly sensitive. The identity of the proteins in the aggregates becomes fairly homogeneous as metal concentrations go as low as 20 μM. The identification of the proteins by mass spectrometry indicates a preponderance of IgG and a minor presence of other different proteins. Therefore, free copper in blood may contribute to the formation of circulating protein aggregates with a core of IgG. This may impact health not only due to the activity of aggregated IgG but also due to the many proteins co-aggregated. Understanding whether the γ-globulin core and the heterogeneous subgroup of proteins elicit differential responses in the organisms requires further research.
Housing, the credit market, and unconventional monetary policies: from the sovereign crisis to the great lockdown
Authors: Ghiaie Hamed 
Published: February 2023

Abstract
This article evaluates the interactions between housing, the credit market, and the ECB’s asset purchase program (APP) from 2015 until 2020 and then in the course of the ECB’s pandemic emergency purchase program (PEPP) in 2020. The model is calibrated for the euro area. The findings illustrate the way in which macrohousing channels affect bank portfolio rebalancing which is the main channel for asset purchases to influence the economy. The results show that asset purchasing performs better during a crisis, particularly if it is conducted for an appropriate extent of time. The findings suggest that the PEPP alone is not sufficient to accelerate recovery. As a result, further actions such as timely targeted fiscal policies are required to step up recovery. However, to protect the financial sector, the PEPP should be extended until the Covid-19 crisis phase is over.
Effectiveness of Maternal Influenza Vaccination in Peru PRIME Cohort
Authors: Owusu Daniel , Dawood Fatimah S , Azziz-Baumgartner Eduardo , Tinoco Yeny , Soto Giselle , Gonzalez Oswaldo , Cabrera Santiago , Florian Richard , Llajaruna Edwin , Hunt Danielle Rentz , Wesley Meredith G , Yau Tat , Arriola Carmen S 
Published: February 2023

Abstract

Background
Few studies have examined influenza vaccine effectiveness (VE) among women during pregnancy in middle-income countries. We used data from a prospective cohort of women who were pregnant in Peru to estimate effectiveness of the 2018 Southern Hemisphere influenza vaccine.

Methods
Women at &lt;28 weeks gestation were enrolled from 4 tertiary level hospitals in Lima, Peru at the start of the 2018 influenza season and followed until the end of their pregnancies. Participants had mid-turbinate nasal swabs collected and tested for influenza by reverse-transcription polymerase chain reaction (RT-PCR) with onset of ≥1 of myalgia, cough, runny nose or nasal congestion, sore throat, or difficulty breathing. Time-varying Cox proportional hazard regression models were used to estimate the risk of RT-PCR-confirmed influenza infection after adjusting for inverse probability treatment weight.

Results
We followed 1896 women for a median of 127 days (interquartile range [IQR], 86–174). Participants had a median age of 29 years (IQR, 24–34). Among the 1896 women, 49% were vaccinated with the 2018 influenza vaccine and 1039 (55%) developed influenza-like illness, 76 (7%) of whom had RT-PCR-confirmed influenza. Incidence rates of RT-PCR-confirmed influenza were 36.6 and 15.3 per 100 000 person-days among women who were unvaccinated and vaccinated, respectively. Adjusted influenza VE was 22% (95% confidence interval, −64.1% to 62.9%).

Conclusions
Participants vaccinated against influenza had more than 50% lower incidence of RT-PCR-confirmed influenza illness. Although the VE estimated through propensity weight-adjusted time-varying Cox regression did not reach statistical significance, our findings provide additional evidence about the value of maternal influenza vaccination in middle-income countries.
Changing Epidemiology of Carbapenemases Among Carbapenem-Resistant Enterobacterales From United States Hospitals and the Activity of Aztreonam-Avibactam Against Contemporary Enterobacterales (2019–2021)
Authors: Sader Helio S , Mendes Rodrigo E , Carvalhaes Cecilia G , Kimbrough John H , Castanheira Mariana 
Published: February 2023

AbstractBackgroundAs the frequency of metallo-β-lactamase (MBL)-producing Enterobacterales is increasing worldwide, effective antimicrobials to treat the infections caused by these organisms are urgently needed.MethodsThe activity of aztreonam-avibactam and comparators were evaluated against 27 834 Enterobacterales isolates collected from 74 US medical centers in 2019–2021. Isolates were susceptibility tested by broth microdilution. An aztreonam-avibactam pharmacokinetic/pharmacodynamic breakpoint of ≤8 mg/L was applied for comparison. Antimicrobial susceptibility and the frequency of key resistance phenotypes were assessed then stratified by year and infection type. Carbapenem-resistant Enterobacterales (CRE) were screened for carbapenemase (CPE) genes by whole genome sequencing.ResultsAztreonam-avibactam inhibited &gt;99.9% of Enterobacterales at ≤8 mg/L. Only 3 isolates (0.01%) had an aztreonam-avibactam minimum inhibitory concentration (MIC) &gt;8 mg/L. The CRE rates were 0.8%, 0.9%, and 1.1% in 2019, 2020, and 2021, respectively; 99.6% (260 of 261) of CRE isolates were inhibited at an aztreonam-avibactam MIC of ≤8 mg/L. The CRE susceptibility to meropenem-vaborbactam decreased from 91.7% in 2019 to 83.1% in 2020 and 76.5% in 2021 (82.1% overall). The CRE, multidrug-resistant, and extensively drug-resistant phenotypes were markedly higher among isolates from pneumonia compared with other infections. The most common carbapenemase among CRE was Klebsiella pneumoniae carbapenemase (65.5% of CRE), followed by New Delhi metallo-β-lactamase (11.1%), oxacillinase (OXA)-48-like (4.6%), Serratia marcescens enzyme (2.3%), and imipenemase (1.5%). Among non-CPE-producing CRE isolates (n = 44; 16.9% of CRE), 97.7% were inhibited at ≤8 mg/L aztreonam-avibactam and 85.4% were meropenem-vaborbactam susceptible.ConclusionsThe frequencies of MBL and OXA-48-type producers increased markedly. Aztreonam-avibactam demonstrated potent and consistent activity against Enterobacterales across infection types and over time.
Missed Opportunities in the Diagnosis of Tuberculosis Meningitis
Authors: Simmons Niamh , Olsen Margaret A , Buss Joanna , Bailey Thomas C , Mejia-Chew Carlos 
Published: February 2023

AbstractBackgroundTuberculosis meningitis (TBM) has high mortality and morbidity. Diagnostic delays can impact TBM outcomes. We aimed to estimate the number of potentially missed opportunities (MOs) to diagnose TBM and determine its impact on 90-day mortality.MethodsThis is a retrospective cohort of adult patients with a central nervous system (CNS) TB International Classification of Diseases, Ninth/Tenth Revision (ICD-9/10) diagnosis code (013*, A17*) identified in the Healthcare Cost and Utilization Project, State Inpatient and State Emergency Department (ED) Databases from 8 states. Missed opportunity was defined as composite of ICD-9/10 diagnosis/procedure codes that included CNS signs/symptoms, systemic illness, or non-CNS TB diagnosis during a hospital/ED visit 180 days before the index TBM admission. Demographics, comorbidities, admission characteristics, mortality, and admission costs were compared between those with and without a MO, and 90-day in-hospital mortality, using univariate and multivariable analyses.ResultsOf 893 patients with TBM, median age at diagnosis was 50 years (interquartile range, 37–64), 61.3% were male, and 35.2% had Medicaid as primary payer. Overall, 407 (45.6%) had a prior hospital or ED visit with an MO code. In-hospital 90-day mortality was not different between those with and without an MO, regardless of the MO coded during an ED visit (13.7% vs 15.2%, P = .73) or a hospitalization (28.2% vs 30.9%, P = .74). Independent risk of 90-day in-hospital mortality was associated with older age, hyponatremia (relative risk [RR], 1.62; 95% confidence interval [CI], 1.1–2.4; P = .01), septicemia (RR, 1.6; 95% CI, 1.03–2.45; P = .03), and mechanical ventilation (RR, 3.4; 95% CI, 2.25–5.3; P &lt; .001) during the index admission.ConclusionsApproximately half the patients coded for TBM had a hospital or ED visit in the previous 6 months meeting the MO definition. We found no association between having an MO for TBM and 90-day in-hospital mortality.
Application of Phage Therapy in a Case of a Chronic Hip-Prosthetic Joint Infection due toPseudomonas aeruginosa: An Italian Real-Life Experience andIn VitroAnalysis
Authors: Cesta Novella , Pini Marco , Mulas Tiziana , Materazzi Alessandro , Ippolito Ernesto , Wagemans Jeroen , Kutateladze Mzia , Fontana Carla , Sarmati Loredana , Tavanti Arianna , Lavigne Rob , Andreoni Massimo , Di Luca Mariagrazia 
Published: February 2023

AbstractBackgroundProsthetic joint infection (PJI) caused by Pseudomonas aeruginosa represents a severe complication in orthopedic surgery. We report the case of a patient with chronic PJI from P. aeruginosa successfully treated with personalized phage therapy (PT) in combination with meropenem.MethodsA 62-year-old woman was affected by a chronic right hip prosthesis infection caused by P. aeruginosa since 2016 . The patient was treated with phage Pa53 (I day 10 mL q8h, then 5 mL q8h via joint drainage for 2 weeks) in association with meropenem (2gr q12h iv) after a surgical procedure. A 2-year clinical follow up was performed. An in vitro bactericidal assay of the phage alone and in combination with meropenem against a 24-hour-old biofilm of bacterial isolate was also carried out.ResultsNo severe adverse events were observed during PT. Two years after suspension, there were no clinical signs of infection relapse, and a marked leukocyte scan showed no pathological uptake areas. In vitro studies showed that the minimum biofilm eradicating concentration of meropenem was 8 µg/mL. No biofilm eradication was observed at 24 hours incubation with phages alone (108 plaque-forming units [PFU]/mL). However, the addition of meropenem at suberadicating concentration (1 µg/mL) to phages at lower titer (103 PFU/mL) resulted in a synergistic eradication after 24 hours of incubation.ConclusionsPersonalized PT, in combination with meropenem, was found to be safe and effective in eradicating P. aeruginosa infection. These data encourage the development of personalized clinical studies aimed at evaluating the efficacy of PT as an adjunct to antibiotic therapy for chronic persistent infections.
The Back Pain Consortium (BACPAC) Research Program Data Harmonization: Rationale for Data Elements and Standards
Authors: Batorsky Anna , Bowden Anton E , Darwin Jessa , Fields Aaron J , Greco Carol M , Harris Richard E , Hue Trisha F , Kakyomya Joseph , Mehling Wolf , O’Neill Conor , Patterson Charity G , Piva Sara R , Sollmann Nico , Toups Vincent , Wasan Ajay D , Wasserman Ronald , Williams David A , Vo Nam V , Psioda Matthew A , McCumber Micah 
Published: February 2023

Abstract

Objective
One aim of the Back Pain Consortium (BACPAC) Research Program is to develop an integrated model of chronic low back pain that is informed by combined data from translational research and clinical trials. We describe efforts to maximize data harmonization and accessibility to facilitate Consortium-wide analyses.

Methods
Consortium-wide working groups established harmonized data elements to be collected in all studies and developed standards for tabular and nontabular data (eg, imaging and omics). The BACPAC Data Portal was developed to facilitate research collaboration across the Consortium.

Results
Clinical experts developed the BACPAC Minimum Dataset with required domains and outcome measures to be collected by use of questionnaires across projects. Other nonrequired domain-specific measures are collected by multiple studies. To optimize cross-study analyses, a modified data standard was developed on the basis of the Clinical Data Interchange Standards Consortium Study Data Tabulation Model to harmonize data structures and facilitate integration of baseline characteristics, participant-reported outcomes, chronic low back pain treatments, clinical exam, functional performance, psychosocial characteristics, quantitative sensory testing, imaging, and biomechanical data. Standards to accommodate the unique features of chronic low back pain data were adopted. Research units submit standardized study data to the BACPAC Data Portal, developed as a secure cloud-based central data repository and computing infrastructure for researchers to access and conduct analyses on data collected by or acquired for BACPAC.

Conclusions
BACPAC harmonization efforts and data standards serve as an innovative model for data integration that could be used as a framework for other consortia with multiple, decentralized research programs.
Lying for Trump? Elite Cue-Taking and Expressive Responding on Vote Method
Authors: Shino Enrijeta , Smith Daniel A , Uribe Laura 
Published: February 2023

AbstractMight elite cues affect how we vote? Extant literature focuses on effects of elite cues on candidate evaluation or policy preference, but we know little about how they might affect vote method preferences. Drawing on a large survey of validated Florida voters, including those who regularly vote by mail, we find that retrospective and prospective misreporting of vote method prior to the 2020 General Election was driven primarily by support for Trump. The president’s supporters who were most politically aware were most likely to disavow their own voting by mail and misreport their anticipated vote method in the November election. Understanding the effects—and limits—of elite cues on the politicization of self-reported political behavior has important implications for pollsters and campaigns, election administrators, voters, and the broader democratic electoral process.
The Differential Impacts of Contingent Employment on Fertility: Evidence from Australia
Authors: Wooden Mark , Trinh Trong-Anh , Mooi-Reci Irma 
Published: February 2023

Abstract
Many studies have reported evidence of negative associations between fixed-term contract employment and fertility. With few exceptions, these studies assume that employment status is exogenous and thus results are likely biased. Furthermore, previous research has mostly not considered whether the effects of employment status on fertility might vary with other worker characteristics. We draw on nineteen years of data from the Household, Income and Labour Dynamics in Australia Survey to investigate the causal effect of contingent forms of employment (including both fixed-term and casual employment) on first births, and how that effect varies with selected worker characteristics. The issue of endogeneity is addressed through the use of instrumental variables estimation. Our main finding is that both fixed-term contracts and casual employment lead to a significantly lower probability of first births among men, with the effect of fixed-term contracts being almost as twice as large as the effect of casual employment. We also find that these negative fertility effects vary with workers’ education, occupational status, country of origin, age, and relationship status. In the case of women, one of the instruments fails to satisfy the exclusion restriction, suggesting endogeneity remains a concern when analyzing female fertility outcomes.
In-vivo processing of nanoassemblies: a neglected framework for recycling to bypass nanotoxicological therapeutics
Authors: Kantak Maithili , Shende Pravin 
Published: February 2023

AbstractThe proof-of-concept of nanomaterials (NMs) in the fields of imaging, diagnosis, treatment, and theranostics shows the importance in biopharmaceuticals development due to structural orientation, on-targeting, and long-term stability. However, biotransformation of NMs and their modified form in human body via recyclable techniques are not explored owing to tiny structures and cytotoxic effects. Recycling of NMs offers advantages of dose reduction, re-utilization of the administered therapeutics providing secondary release, and decrease in nanotoxicity in human body. Therefore, approaches like in-vivo re-processing and bio-recycling are essential to overcome nanocargo system-associated toxicities such as hepatotoxicity, nephrotoxicity, neurotoxicity, and lung toxicity. After 3–5 stages of recycling process of some NMs of gold, lipid, iron oxide, polymer, silver, and graphene in spleen, kidney, and Kupffer’s cells retain biological efficiency in the body. Thus, substantial attention towards recyclability and reusability of NMs for sustainable development necessitates further advancement in healthcare for effective therapy. This review article outlines biotransformation of engineered NMs as a valuable source of drug carriers and biocatalyst with critical strategies like pH modification, flocculation, or magnetization for recovery of NMs in the body. Furthermore, this article summarizes the challenges of recycled NMs and advances in integrated technologies such as artificial intelligence, machine learning, in-silico assay, etc. Therefore, potential contribution of NM’s life-cycle in the recovery of nanosystems for futuristic developments require consideration in site-specific delivery, reduction of dose, remodeling in breast cancer therapy, wound healing action, antibacterial effect, and for bioremediation to develop ideal nanotherapeutics.
First Report and Draft Genome Resource of a Unique Opportunistic Fusarium solani Pathogen Associated with Unknown Dark Galls in Sugarbeet
Authors: Navasca Abbeah , Singh Jatinder , Rivera-Varas Viviana , Geddes Barney , Secor Gary , Gill Upinder , Baldwin Thomas 
Published: February 2023

Fusarium disease of sugarbeet is a threat to sugarbeet production and can cause significant losses. During routine evaluation, a unique Fusarium species was solely isolated from unknown dark galls in sugarbeets from Wilkin County, MN, U.S.A. Analysis of the RPB2 gene placed this isolate in the Fusarium solani FSSC 5 clade (100.0% similarity) but uniquely separated from the potato F. solani. Sequencing of this Fusarium species by Minion Nanopore Systems resulted in a draft genome assembly of 19 contigs with a genome size of 59.3 Mb and GC content of 50.66%. A total of 18,900 protein-coding genes, 37 secondary metabolite clusters, 1,559 secreted proteins, 668 carbohydrate-active enzymes, and 404 effectors were predicted in the genome. Pathogenicity tests showed mild vascular discoloration in inoculated sugarbeets unaccompanied by external symptoms, suggesting weak pathogenic ability of this species, indicative of an opportunistic pathogen. These results extend our understanding of this unique opportunistic Fusarium solani isolated from sugarbeet. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .