bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Curative Effect of Acupuncture Therapy Under Artificial Intelligence Combined with Integrated Chinese and Western Medicine for Lung Cancer Patients and The Intervention Effect of Side Effects After Chemotherapy
Authors: Zhu Dabin , Cai Genghui , Lin Xiuyao , Zheng Yuebao 
Published: May 2023

Abstract
Objective:
this work aimed to investigate the clinical efficacy of artificial intelligence-based acupuncture combined with comprehensive drugs in the treatment of lung cancer (LC) and its intervention effect in the side effects after chemotherapy.
Methods:
88 patients with LC confirmed in Affiliated Quanzhou First Hospital of Fujian Medical University were studied. They were randomly divided into two groups: the experimental group (EG-laser acupuncture robot + integrated Chinese and Western medicine program) and the control group (integrated Chinese and Western medicine program), with 44 cases. The therapeutic effects and chemotherapy side effects of the two groups were compared and analyzed.In the EG, the number of patients whose treatment effects were not significantly effective, effective, and ineffective was 2, 33, and 9, and the number of patients whose treatment effects were not significantly effective, effective, and ineffective was 3, 20, and 21, respectively in the controls, P < 0.05. After treatment, the scores of each dimension in the EG and controls were 30.7 ± 11.2 VS 33.9 ± 10.07, 20.08 ± 4.33 VS 24.5 ± 5.11, 8.77 ± 3.31 VS 11.6 ± 2.88, 8.33 ± 3.36 VS 9.36 ± 4.08, 3.22 ± 1.18 VS 5.31 ± 1.27, P <0.05. After treatment, the TCM syndrome scores of the EG and controls were 19.8 ± 6.06 and 23.6 ± 7.33, P < 0.05. After treatment, the number of patients with nausea and vomiting grade 0, I, II, III, and IV in the EG and controls was compared, and the results were 20 VS 7, 18 VS 3, 3 VS 20, 2 VS 10, and 1 VS 4, P < 0.05. After treatment, the PFS score of the EG was 4.87 ± 2.01, and the PFS score in the controls was 7.11 ± 1.68, P < 0.05. After treatment, the measured values of CD3+, CD4+, and CD8+ in the two groups were 56.08 ± 22.3 VS 52.9 ± 21.81, 35.2 ± 12.3 VS 31.3 ± 11.09, and 26.08 ± 7.74 VS 20.7 ± 8.35, P < 0.05. Acupuncture combined with integrated medicine has a high application value in the treatment of LC and the reduction of adverse reactions (AR).
No tension, no change? - Use and influencing factors of a Dutch nursing guideline on Activities of Daily Living (ADL) – a pilot implementation study
Authors: Cremer Svenja , Zwakhalen Sandra M.G. , de Man Janneke M. , Metzelthin Silke F. , Bleijlevens Michel H.C. 
Published: May 2023

Abstract
Background
Care for activities of daily living (ADL) performed by nursing professionals is poorly informed by scientific evidence. To address the nursing professionals’ need for guidance, we developed a clinical practice guideline on ADL care. This guideline comprises key recommendations (KRs) on involving care receivers and informal caregivers in ADL care, identifying ADL care needs, and effective ADL interventions. With the actual guideline use depending on different factors, insight into these influencing factors is necessary prior to the actual implementation. In a pilot implementation, we aimed to measure the use of KRs in various relevant care settings and to identify and explore these influencing factors.
Methods
In a pilot implementation study, mixed methods were applied where (1) nursing professionals weekly and retrospectively registered the frequency of the used key recommendations in a three-week period; (2) a survey was used to identify impeding and facilitating factors; and (3) focus groups were conducted to explore additional factors and how they influence KR use. Descriptive analysis was performed on registration and survey data, while focus group data was analyzed deductively.
Results
Seven nursing care teams participated from the hospital (n = 1), rehabilitation (n = 2), home-care (n = 1), and long-term care (n = 3). The use of KRs varied between KRs and across care settings, with the most frequently used KRs being on involving care receivers in ADL related care choices. KRs were least applied to assessing ADL functioning. The survey on factors influencing the implementation showed how the majority of factors across domains and care settings were generally perceived as facilitating, including the inner setting, the innovation itself, and individuals. Impeding factors mainly related to low tension for change and limited personal benefits. Additional constructs addressed in six focus group sessions included innovation characteristics (e.g. procedural clarity) and cooperation with care receivers.
Conclusions
The KRs generally appear implementable across care settings, with limited factors hindering the KR use. Despite the impression that the KRs are generally perceived as highly compatible with current norms and workflows, low tension for change raises questions on the awareness of current opportunities for improvement in ADL nursing care.
A pan-cancer analysis of the oncogenic role of Bcl2-associated athanogene 2(BAG2) in human tumors
Authors: Liu Qian , Tang Baoyuan , Wei Hong , Tian Binbin , Zhang Zuyu , Wang Yaoqiang , Luo Ruiying , Luo Changjiang 
Published: May 2023

Abstract
Background: As a major public health problem in the world, malignant tumor seriously threatens human life and health. The pathogenesis of cancer has been widely discussed. It is usually caused by the dysfunction of genes that regulate the basic process of cells. Studies have confirmed that Bcl-2-associated antiapoptotic gene 2 (BAG2) is widely expressed in a variety of malignant tumors. Through interaction with relevant signal molecules in the tumor microenvironment, BAG2 is involved in regulating tumor cell apoptosis,
proliferation, and migration. BAG2 is expected to become a new target for
tumor therapy in the future. Although emerging a large number of evidence supports the relationship between BAG2 and cancers, no pan-cancer analysis is available.
Methods and Results: We thus explored the potential oncogenic roles of BAG2 based on the datasets of TCGA (The cancer genome atlas) and GEO (Gene expression omnibus). The comprehensive analyses for BAG2 in various tumors, including gene expression, diagnosis, prognosis, immune-related features, genetic alteration, and function enrichment, were conducted based on multiple databases and analysis tools. Immunofluorescence to detect the locations of BAG2 in three cancer cell lines. To verify the results further, immunoblotting was used to measure the expression of BAG2 in KIRC patients’ tissue samples. The drug of BAG2 were analyzed by using the Drugbank database. Take together, from our comprehensive pan cancer analysis of BAG2, we found a statistical association between BAG2 expression and clinical prognosis, immune cell infiltration, tumor mutation burden or microsatellite instability of a variety of human cancers.
Conclusions: These results suggest that BAG2 might be served as prognostic biomarkers for cancer.
Development of microfibrillated cellulose yarn with guar gum
Authors: Colares Jair Rogério , Correia Pedro Ygor , Silva Fernando Da Silva , Menini Poliana Dariva , Silva Danillo Wisky , Oliveira Michel Picanço , Moulin Jordão Cabral 
Published: May 2023

Abstract
Cellulose microfibrils (MFC) have interesting characteristics that make them promise for applications in replacement of fossil-based products. This study aims at the production and characterization of monocomponent, bicomponent, and mixed bicomponent MFC yarns with guar gum (GG), using alcohol as solvent and coagulation time of 60, 90 and 120 seconds in the dry-wet-spinning process. The three types of yarn were possible to be produced and had good interaction between MFC and GG. The bicomponent yarns were greater mechanical and showed interesting specific resistance compared to aluminum and steel.
Establishment of a regeneration system for ‘Minihyang,’ a domestic citrus variety with high utility as a genetic resource
Authors: Jin Seong-Beom , Choi Cheol-Woo , Park Suk-Man , Kim Min Ju , Kim Jae-Hong , Yun Su-Hyun 
Published: May 2023

Abstract
Background Citrus ‘Minihyang’ is a novel citrus cultivar created through the hybridization of Citrus kinokuni and Citrus poonensis. This domestic cultivar has a small fruit size and high sugar content, making it highly valuable in the niche market both for ornamental and commercial purposes. Additionally, as a genetic resource, ‘Minihyang’ is highly valuable. However, the lack of a tissue culture system for ‘Minihyang’ could potentially constrain the utilization of bioengineering techniques for its cultivation. Therefore, in this study, we aimed to develop a regeneration system for ‘Minihyang’ using cultured cells of unfertilized and undeveloped seeds in mature fruits.Results Somatic embryogenic cells were obtained on somatic embryogenesis induction modified Murashige and Tucker (SIME) medium, and the propagated cells were obtained through subculture at 4-week intervals in a modified Murashige and Skoog (EMS) medium. Rather than normal cotyledon-stage embryos, abnormal globular embryos were observed after 4 weeks of culture in an EMS medium containing 70 g·L− 1 lactose and 16 g·L− 1 agar. Through the regeneration of plants from these abnormal globular embryos, somatic embryos with developing shoots and roots were obtained within 3 weeks of culture in an EMS medium containing 0.05 M sorbitol and 0.05 M galactose as carbohydrate sources, 0.5 mg·L− 1 GA3, and 2 g·L− 1 gelrite. These embryos were transferred to and cultured in a basic MS medium enriched with 500 mg·L− 1 malt extract, 50 g·L− 1 sucrose, and 8 g·L− 1 agar to produce normal plants.Conclusions ‘Minihyang’ can serve as a promising genetic resource for developing bioactive cultivars using biotechnological techniques and can be used to breed cultivars that can be consumed whole.
Deep Ensemble Stacked Technique for the Classification of Liver Disease Using Artificial Neural Networks at the Base Level and Random Forest at the Meta Level
Authors: Bhusnurmath Rohini A. , Betageri Shivaleela 
Published: May 2023

Abstract
Liver is the most noticeable and metabolically active organs in the human body. Damage to this organ might result in liver failure and a loss of life. The early detection of liver infection is critical for effective therapy. The main goal of the research is to identify liver illness using machine learning and deep learning classification algorithms. The proposed "Deep ensemble stacked model" is implemented on the “Indian liver Patient Dataset”. An attempt is made to analyze the data through various pre-processing and visualization techniques to understand which factors affect the liver. An artificial neural network is used as the model's primary training and testing tool. The new training set is created for the meta-level consisting of base-level predictions. The random forest classifier is used at the meta level which serves as a meta classifier for the final prediction. The deep ensemble stacked model performed better than the most recent research with 98.29% of classification accuracy, 97.43% of precision, 100% of recall rate, and 98.69% of f1-score. To evaluate the effectiveness of the suggested approach, the outcomes are also contrasted with well-known machine and deep learning models.
Determinants of Sun Protection Behaviors among Students: A Path Analysis Based on the Protection Motivation Theory
Authors: Okati-Aliabad Hassan , Hosseini Esmat-Sadat , MorowatiSharifabad Mohammad Ali , Borzu Zahra Arab , Ardakani Mohamad Ebrahimzadeh , Shahreki Sajad 
Published: May 2023

Abstract
Background: Prolonged exposure to ultraviolet (UV) rays from the sun increases the risk of skin cancer. Understanding the factors that influence the adoption of preventive behaviors is crucial for designing effective interventions. This study utilized path analysis based on the Protection Motivation Theory to identify these factors.
Methods: A cross-sectional study was conducted on 501 students randomly selected from elementary schools in Zahedan. Participants completed an online self-administered questionnaire that assessed constructs of the Protection Motivation Theory (PMT), as well as demographic characteristics. The collected data were analyzed using SPSS and AMOS software to perform path analysis and predict sun protection behaviors
Results: Among the participants, 46.1% reported wearing long-sleeved clothing, 24.0% wore wide-brimmed sun hats, 23.0% used sunglasses, 21.2% applied sunscreen, 14.6% sought shade, 13.0% had used sunscreen in the last month, and 8% reapplied sunscreen after washing their hands. The PMT accounted for 46% of the variance in protection motivation and 30% of the variance in sun protection behaviors. Self-efficacy emerged as the strongest predictor of protection motivation (ß .50, p< 0.001). Additionally, self-efficacy (ß .23, p< 0.001) and response efficacy (ß .20, p< 0.001) were the strongest predictors of sun protection behaviors.
Conclusions: The PMT effectively predicts sun protection behaviors and interventions based on this theory can serve as a framework for skin cancer prevention interventions among students. Emphasizing self-efficacy to protect oneself from the harmful effects of UV rays should be a priority in programs aimed at promoting preventive behaviors among students.
An exceedingly rare case of separated drainage of the cystic duct, the common bile duct and the main pancreatic duct documented on magnetic resonance cholangiopancreatography
Authors: Brandi Nicolò , Fiscaletti Marta , Renzulli Matteo 
Published: May 2023

Abstract
Anatomical variations of the intra- and extra-hepatic biliary system are common, including those affecting the course and insertion point of the cystic duct. Adequate knowledge of such variations and an appropriate roadmap before any surgical, endoscopic or percutaneous procedure help in preventing associated iatrogenic complications. Magnetic resonance cholangiopancreatography (MRCP) can precisely delineate the anatomy of the biliary system preoperatively. We report the case of a 72-year-old female patient who presented with chronic right upper quadrant abdominal pain of 6 months duration, which had acutely worsened over the previous 2 weeks, and no other comorbidities. Blood tests were normal. Abdominal ultrasound revealed a slight dilatation of the common hepatic duct (10 mm) but no gallstones or sludge were demonstrated. MRCP excluded choledocholithiasis but revealed a cystic duct coursing medial to the common bile duct before anastomosing at the level of the ampulla of Vater. Trifurcation (Type 2 variant) of the intra-hepatic bile system was also observed. To the best of the Authors’ knowledge, this is the very first report of this exceptionally rare anatomic cystic duct anomaly on MRCP.
Deciphering the role of MFGE8 in lactation biology using CRISPR- CAS9 based gene editing in Buffalo mammary epithelial cells
Authors: VATS PREETI , Kumar Rohit , Kumar Raghvendra , Kaushik Jai K. , Mohanty Ashok K. , Kumar Sudarshan 
Published: May 2023

Abstract
Milk fat globule EGF factor 8 (MFGE8) also known as Lactadherin is a glycoprotein which plays a crucial role in mammary gland remodeling. Our group has previously identified MFGE8 as a marker associated with high milk yielding cows. Here, we have generated MFGE8 knock-out buffalo mammary epithelial cells (BuMEC) via CRISPR-cas9 technology to decipher its role in lactation biology. Among three gRNAs used to generate knock-outs, gRNA3 reduced MFGE8 expression with better efficiency which was confirmed at transcriptomic and proteomic level and the stable knock-out cells obtained were named mfge8-/-/gRNA3. The amplicon sequencing of the edited region using next generation sequencing (NGS) showed that 54% of total reads showed indels, 3-4 bp upstream to PAM site in 2nd exon. To comprehend the role of MFGE8, mfge8-/-/gRNA3 cells were examined for proteome level changes in comparison to wild type cells using an iTRAQ experiment. A total 4282 proteins were identified in mfge8-/-/gRNA3 cells and among them 178 were found to be differentially expressed above and below a threshold of ≥1.5 and ≤0.6. Majority of DEPs were found to be associated with regulation of hydrolase activity, endopeptidase activity and cytoskeletal organization and some DEPs including FABP3, FABP4, FABP5, KNG1, MT2A, CD82 and SERPINH1 belonged to genes associated with milk synthesis. To the best of our knowledge, this is the first study which provides a comprehensive proteome profile of MFGE8 knockout BuMEC and explores the downstream effects of disruption of MFGE8 gene. Overall, the present study will provide new insights into lactation biology.
Corrosion Resistance of Unlacquered Chromium-Plated Steel Sheets – Study on the Influence of Pickling and Chemical Treatment Steps of the Production Process
Authors: Oliveira Alessandro D. , Bettencourt Gabriel F. , Santos João L.C. , de Jesus Daniela F.G. , Almeida Tatiana C. 
Published: May 2023

Abstract
The corrosion resistance of chromium-plated steel sheets produced on an industrial scale was investigated. Two parameters of the production process were considered: pickling and chemical treatment. The specimens were produced at the industrial plant considering two different pickling conditions and two different chemical treatments: non-electrolytic and electrolytic pickling and non-electrolytic and electrolytic passivation respectively. Accelerated corrosion tests in the humid chamber, microscopy analyses, analyses of roughness and content of trivalent chromium in the passivation film and analyses of the content of metallic chromium in the coating by coulometry technique were performed. The results showed a low corrosion resistance of the materials produced with the non-electrolytic passivation, regardless of the pickling condition. The highest degree of protection of the base steel was achieved for the specimen produced by using the electrolytic route for both pickling and chemical treatment steps. This condition produced a mass of trivalent chromium in the passivation film greater than 8.0 mg∙m−², which provided an effective performance of the chromium-plated steel sheet.
The development of the solution search method based on the improved bee colony algorithm
Authors: Shyshatskyi Andrii , Ishchenko Alexander , Salnyk Serhii , Trotsko Oleksandr , Shabanova-Kushnarenko Lyubov , Velychko Vira , Kornienko Ruslan 
Published: May 2023

Active digitization of people's daily life leads to the use of the decision-making support systems (DMSS). DMSS is actively used in data processing, forecasting the course of various processes, providing informational support for the decision-making process by decision makers. However, a number of problems arise while evaluating monitoring objects, namely: a large number of destabilizing factors affecting the efficiency of the processes of information collection, processing and transmission; high dynamism of changes in the state and composition of heterogeneous monitoring objects during the conduct of hostilities (operations); high dynamism of conducting hostilities (operations); the uncertainty of the initial situation and the noise of the initial data. In this article, a method of finding solutions based on an improved bee colony algorithm was developed.
The efficiency of information processing is achieved by learning the architecture of artificial neural networks; taking into account the type of uncertainty of the information to be evaluated; the use of an improved algorithm of the bee colony, the use of an unordered linguistic scale of measurements with adjustment coefficients for the degree of awareness and the degree of noise of the initial data. An approbation of the use of the proposed method was carried out on the example of assessing the state of the operational grouping of troops (forces). The method is proposed to be used in the development of software for automated systems of control of troops and weapons, namely, in the modernization of existing and development of new automated systems of control of troops and weapons. The evaluation of the effectiveness of the proposed method showed an increase in the efficiency of the evaluation at the level of 21–28 % in terms of the efficiency of information processing
ANAIS III CIOI - CONGRESSO INTERNACIONAL DE ODONTOLOGIA INNOVATION
Authors: Freitas Amílcar , Almeida Érika Oliveira de , Galvao Cecília Santos 
Published: May 2023

Nos dias 2 a 4 de junho de 2022 ocorreu a 3a edição do Congresso Internacional de Odontologia Innovation (CIOI), reunindo 940 participantes no Centro de Convenções de Natal-RN. Foram 3 dias de muita atualização nas diferentes áreas da Odontologia, contando com 52 palestras e 12 hands-on com professores de 5 países. Além disso, foram apresentados 175 trabalhos científicos por profissionais e acadêmicos de Odontologia de todas as regiões do Brasil, especialmente do Nordeste.
O CIOI é um evento de natureza multidisciplinar, com ênfase em ciência, tecnologia e inovação, sendo de grande importância para a odontologia potiguar por compartilhar experiências de profissionais internacionais, nacionais e acadêmicos, com a intenção de expor resultados de pesquisas científicas aliados a experiência clínica dos mesmos de forma a desenvolver sendo crítico e reflexivo sobre vários planejamentos e tratamentos dentro da odontologia.
Nessa 3a edição, tivemos o 1a Meeting de Implantodontia do Norte Nordeste, 1a Meeting de Odontologia digital e 1a Meeting Brasileiro de Harmonização Orofacial, além de professores das áreas de periodontia, reabilitação oral, dentística, cirurgia buco-maxilo-facial, endodontia, pacientes especiais, patologia e estomatologia, marketing, odontologia social e técnicos em prótese dentária. Foi um evento muito especial e importante para a odontologia potiguar. Gostaríamos de agradecer a presença de todos, incluindo os palestrantes, colaboradores, empresas e todos os congressistas que confiaram no nosso evento.
Natural Amphibian-Derived Host Defense Peptides: Peptide Immunomodulators
with Potential Therapeutic Value
Authors: Shi Jie , Wu Jing , Feng Guizhu , Yang Hailong , Mu Lixian 
Published: May 2023

Abstract:
Due to the rapid evolution of bacterial drug resistance, anti-infective treatment has become
a global problem. Therefore, there is an urgent need to develop alternative treatment strategies. Host
defense peptides (HDPs) are important components of the natural immune system and are widely
distributed in the animal and plant kingdoms. Amphibians, especially their skin, provide a rich source
of natural HDPs encoded by genes. These HDPs exhibit not only broad-spectrum antimicrobial
activity but also a wide range of immunoregulatory characteristics, including modulation of antiinflammatory
and proinflammatory reactions, regulation of specific cellular functions, enhancement of
immune chemotaxis, regulation of adaptive immunity, and promotion of wound healing. They also
show potent therapeutic effects on infectious and inflammatory diseases caused by pathogenic
microorganisms. Thus, in the current review, we summarize the extensive immunomodulatory
functions of natural amphibian HDPs, as well as the challenges of clinical development and potential
solutions, which have important implications for the development of new anti-infective drugs.
Pyrazolo[4,3-H]quinazolines as Cyclin-dependent Kinase Inhibitors
for Treating Cancer
Authors: De Surya K. 
Published: May 2023

Abstract:
The application describes the synthesis of 1H-pyrazolo[4,3-H]quinazoline
compounds for treating cell proliferation dysfunction and is a broad-spectrum and strongly-
active inhibitor for a cell cyclin-dependent kinase (CDK).