bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Community-Based Observational Study on Knowledge, Attitude, and Practice of Single-Use Plastics Ban in Rural Puducherry, South India
Authors: Kittu Devi , Aruljothi Sivapushani , Chellamuthu Lalithambigai 
Published: September 2023

Background: India's industries produce nearly 9,000,000 metric tons of disposable plastic annually. Government of Puducherry implemented a ban on single-use plastics from 1st August 2019. This study aimed to evaluate the knowledge, attitude, and practice (KAP) levels concerning the use and legislation of single-use plastics among rural Puducherry's community residents.
Methods: A 6-month community-based observational study was conducted in rural Puducherry using multistage random sampling among 450 households. A semi-structured questionnaire was administered to an adult member (aged > 18 years) in each household before and after the plastic ban. Data collection utilized the Epi-collect 5 application, and SPSS v16 was used for statistical analysis, employing paired t-test and chi-square test (p-value < 0.05)
Results: Mean age of study participants was 39.64 (13.23) years, nearly 57% of them were female. Before ban, 80.4% of the subjects were carrying their shopping contents using plastic bags provided by the seller in the rural area, whereas after ban implementation, it has reduced to 16.4%. Mean KAP score before ban was 8 +2.8 (95% CI: 7.7-8.2) and after ban, it increased to 15.2 +1.8 (95% CI: 15-15.4). The pre- and post-ban KAP scores differences were found to be statistically significant (p-value < 0.05). The perception of the law banning the use of plastic bags was found to be significantly higher in younger age group, female gender, and groups with higher educational and occupational status (p = 0.01)
Conclusion: The study results will be useful for planning future needs and Information, Education Communication strategies for effective implementation and plastic use reduction in future.
Acervo especial da Escola de Agronomia do Nordeste sob a ótica do patrimônio bibliográfico
Authors: Nascimento Oliveira Júccia Nathielle do , Juvenal Freire de Oliveira Bernardina Maria 
Published: September 2023

Apresenta e discute a coleção especial da Escola de Agronomia do Nordeste da Biblioteca Setorial Francisco Tancredo Torres (BSFTT) da Universidade Federal da Paraíba (UFPB), enquanto patrimônio bibliográfico científico. Entende-se a coleção a partir dos livros, documentos, folhetos, entre outros, produtos da cultura escrita e material. A pesquisa caracteriza as obras quanto ao seu aspecto físico, de representação da história/memória científica e institucional. Metodologicamente, a abordagem é qualitativa de cunho teórico-exploratório do tipo documental, tomando como corpus analítico o acervo especial aliado à análise documental em cotejamento teórico com as concepções de Patrimônio Bibliográfico adotadas nesta investigação. O resultado sugere que a BSFTT e o Centro de Ciências Agrárias-UFPB reconheçam o acervo como patrimônio bibliográfico e sua necessidade de preservação.
Palavras-chave: Coleção especial. Escola de Agronomia do Nordeste. Patrimônio Bibliográfico.
Comprehensive Analysis of Indonesian Retail Stocks Valuation in 2023
Authors: Sunandar Agus , Dwi Fitrizal Salim  
Published: September 2023

Modern retail businesses in Indonesia are growing rapidly thanks to open market opportunities, manufacturing businesses that support product supply, and government support for economic growth through retail development. The purpose of this study is to determine the intrinsic value of shares of companies engaged in the food and staples retail sub-sector which in this case is represented by PT. Sumber Alfaria Trijaya, Tbk. (AMRT), PT. Diamond Food Indonesia, Tbk. (DMND), PT. Midi Utama Indonesia, Tbk. (MIDI), PT. Enseval Putera Megatrading, Tbk. (EPMT), and PT. Millenium Pharmacon Internatioanl, Tbk. (SDPC) listed on the Indonesia Stock Exchange (IDX). This research uses historical data for 2018-2022 which will be used as the basis for projections for 2023-2027. The results showed that by using the Discounted Cash Flow (DCF) method, specifically the Free Cash Flow to Firm (FCFF) approach, under an optimistic scenario, the intrinsic values of AMRT, SDPC, and DMND were undervalued. EPMT and MIDI stocks are overvalued. In the moderate scenario, the intrinsic values of AMRT, MIDI, EPMT, and DMND are overvalued, while SDPC is undervalued. Calculations on a pessimistic scenario, all companies studied are overvalued. In this study, the valuation of stocks was also conducted using the Relative Valuation (RV) method with the Price to Earnings Ratio (PER) and Price to Book Value (PBV) approaches. In an optimistic scenario, the stocks of AMRT, MIDI, and SDPC are considered expensive, while EPMT and DMND are seen cheap. In a moderat scenario, the stocks AMRT, EPMT, and SDPC are considered undervalued, while MIDI and DMND are seen expensive. In a pessimistic scenario, it is observed that AMRT, EPMT, and SDPC are undervalued, whereas MIDI and DMND are considered overvalued. This research aims to provide an objective assessment of the company, which investors can use to consider investments and by companies to enhance corporate value.
Financial Distress Classification Using Feedforward Neural Network Based on Altman and Ohlson Financial Ratios
Authors: Pratiwi Annisa Salsabila , Siswono Galuh Oktavia , Saputri Prilyandari Dina 
Published: September 2023

The ever-changing economy requires companies to anticipate future conditions in order to avoid financial distress, a continuous decline in financial conditions. The research focused on comparing Altman and Ohlson’s financial ratio in classifying financial distress on Property and Real Estate companies using the Feedforward Neural Network. The data used is the financial report data of 19 Property and Real Estate companies listed on the Indonesian Stock Exchange in 2016-2022, with the initial status of financial conditions based on earnings per share. (EPS). The study also used the Synthetic Minority Oversampling Technique (SMOTE) method to address class imbalances. The best financial ratio is selected based on accuracy values and Area Under Curve (AUC). Altman’s financial ratio with the FFNN model architecture (5-2-1) with a balance of 60:40 yields an accuracy of 84.62% and an AUC of 0.8325. The Ohlson Financial ratio with the 60:40 data balancing process and the FFNN model architecture (9-4-1) yields an accuracy of 93.27% and an AUC of 0.9045. Thus, in predicting financial distress in companies in the Property and Real Estate sector, Ohlson’s financial ratio with the predictor variables Corporate Size (SIZE), Total Liabilities to Total Assets (TLTA), Working Capital to Total Acts (WCTA), Current Liability to Current Asset (CLCA), OENEG, Net Income to total assets (NITA), Cash Flows Operating to Total Responsibilities (CFOTL), Net Revenue (INTWO), and Net Incoming Change (CHIN) yielded the best results. This best ratio can be used as a consideration in using alternative financial ratio to classify financial distress.
Development of an Endoscopic Spine Surgery Program
Authors: Stone Benjamin K. , Paradkar Ria , Anderson George M. , Daniels Alan , Iyer Sravisht , Derman Peter B. , Telfeian Albert E. , Basques Bryce 
Published: September 2023

Abstract
Endoscopic spine surgery (ESS) is an innovative technique allowing for minimally invasive, direct visualization of spinal abnormalities. The growth of ESS in the United States has been stunted by high start-up costs, low reimbursement rates, and the steep learning curve associated with mastering endoscopic techniques. Hergrae, we describe the current state and future direction of ESS and provide key action items for ESS program implementation.
Dismountable and non-Dismountable Spaces via Proximity Space
Authors: Almohammed Raghad , Jabar L .A.A. 
Published: September 2023

اهتم كثيرا من الباحثين في دراسة اغلب المشكلات بعد تحويلها الى صيغ رياضية داخل فضاء القرب لسهولة توظيف هذاالفضاء مع المشكلات الحياتية المختلفة التي تواجهنا. لذلك يصب اهتمام البحث في ايجاد صفة جديدة الى فضاءات القرب باستخدام خواص القرب وخواص العناقيد وربطها معا للحصول على نقاط تراكمية جديدة اطلقنا عليها اسم نقاط كثه ومجموعة كل هذه النقاط اطلقنا عليها اسم مجموعة كثه حيث تم تكوين اساس رياضي متماسك الى الصيغة التبلوجية التي نبحث عنها والتي اطلقنا عليها التفكك واذا كانالفضاء لا يحمل هذه الصفة نطلق عليه فضاء غير قابل للتفكك.
The role of the APE1 Asp148Glu polymorphism on the risk of acute myeloid leukemia in Iraqi patients
Authors: Jasiem Thamer Mouhi , Al-Husseini Rand Muhammed Abdul-Hussein 
Published: September 2023

ابيضاض الدم النخاعي الحاد هو أكثر أنواع امراض الدم الخبيثة شيوعًا عند البالغين. يعد انتشار الخلايا الطافرة الغير مسيطر عليها للأسلاف النخاعية الغير متمايزة سمة مميزة لهذا المرض. يمكن إصلاح تلف الحمض النووي عن طريق مجموعة متنوعة من الأنظمة الأنزيمية الموجودة في الخلايا حقيقية النواة. تتشكل الخلايا الطافرة عندما لا يمكن إصلاح تلف الحمض النووي بواسطة آليات إصلاح الخلية. إحدى آليات إصلاح الحمض النووي هي مسار إصلاح استئصال القاعدة ، التي تكون المسئولة عن تصحيح الأضرار الصغيرة الناتجة عن التلف ألتأكسدي أو والقلوية أو المثيلة.
اشتملت الدراسة على 70 مريضًا مصابًا بسرطان الدم النخاعي الحاد - 37 أنثى و 33 ذكرًا - بالإضافة إلى 30 فردًا سليمًا كمجموعة سيطرة. تم استخدام مجموعة استخلاص الحمض النووي gSYNCTM لاستخراج الحمض النووي من عينات الدم الكاملة من مجموعات الدراسة. تم استخدام طريقة PCR-RFLP لتحديد تعدد الأشكال Asp148 Glu للجين APE1
في التحليل الجيني ، تبين أن الزيادة في النمط الجيني T/T وأليل T في تعدد الأشكال في كودون APE1 148 يلعب دورًا وقائيًا في مرض ابيضاض الدم النخاعي الحادAML ، وأن الزيادة في النمط الجيني G / G يمكن أن تترافق مع خطر الإصابة بسرطان الدم الحاد. . أظهرت النتائج أن النمط الجيني المتغاير لجين APE1 ، Asp 148 Glu (T / G) وأليل G كانت أعلى بشكل ملحوظ (P <0.05) في مرضى AML مقارنة بمجموعة السيطرة . في تسلسل المنطقة التي تم دراستها ، وجد أن هناك موقعًا للتغاير يقع بين GATC و GAGC ، حيث يمثل التغيير في النيوكليوتيدات T إلى G موقع تقييد الإنزيم القاطع.
حيث ارتبط النمط الجيني متعدد الأشكال 148 Glu> Asp من جين APE1 مع تطور AML في المرضى العراقيين. أثبتت الدراسة أن حاملي النمط الجيني T / T لديهم مخاطر أقل لتطور مرض ابيضاض الدم النخاعي الحادAML ، في حين أن حاملي الأليلات G لديهم مخاطر متزايدة.
A Continuous Projection-Based EDFM Model for Flow in Fractured Reservoirs
Authors: Rashid Harun U. , Olorode Olufemi 
Published: September 2023

Summary
Various researchers have evaluated different methods of modeling fractured reservoirs accurately and efficiently. Of these methods, the embedded discrete fracture model (EDFM) is one of the most popular because it does not require the mesh for the simulation domain to conform to the orientation of the natural fractures. However, it is limited because it cannot accurately model low-conductivity fractures. Although the projection-based EDFM (pEDFM) was developed to address this limitation of the EDFM, recent studies show that pEDFM still cannot accurately model low-conductivity fractures that are neither parallel to the simulation grid nor cutting through the matrix cell diagonals. In these cases, it has been observed that reservoir fluids can flow around low- or even zero-conductivity fractures.
This paper presents a rigorous analysis, which reveals that the error when modeling inclined low-conductivity fractures with pEDFM is because the projections of the fracture on the gridblock faces are discontinuous. This discontinuity implies that the matrix cell interfaces along the path of the fractures only project a fraction of the fracture area on these interfaces in each direction. So, none of these faces captures the sealing potential of these interfaces, and the pore fluid can flow around even zero-conductivity fractures. We present a robust algorithm that ensures that the projections of inclined fractures on cell faces are continuous in 3D. We refer to the model based on this algorithm as the continuous projection-based EDFM (CPEDFM) and show that it directly solves the pEDFM limitation.
We present the simulation of several cases and their selected projection faces to demonstrate why CPEDFM works. We also verify the CPEDFM method by comparing the CPEDFM and pEDFM model results to high-resolution simulation results. To demonstrate the feasibility of modeling complex, realistic systems using CPEDFM, we simulate a 3D compositional Eagle Ford shale reservoir with 75 low-conductivity and 75 high-conductivity fractures. The results show that pEDFM overestimates production because it does not fully account for the sealing effects of inclined low-conductivity fractures. In conclusion, this paper presents a novel numerical model for accurately and efficiently simulating reservoirs containing fractures of arbitrary conductivity, size, and orientation in 3D.
Incorporating complexity is essential for driving farm system change
Authors: Pilditch Toby , Bailey Richard , Merkl Andreas 
Published: September 2023

Abstract
Agricultural transformation is imperative to achieve environmental and social objectives. However, the complexity and variety of agricultural systems, and the myriad factors impacting farmer decision-making often hinder policy efficacy. Our research provides a new, integrated perspective on this issue, using a model that incorporates the complexities of both farmers and farm systems to enable more complete explanatory mechanisms for policy success and failure. We unpack a hierarchy of barriers to change, noting how those barriers interact, including exposition of previously ill-understood factors (e.g., farmer psychology). Via inclusion of social and complex system dynamics, we also show how policy bundles can exploit tipping-point dynamics. Our findings provide an explanation for disparate agricultural system outcomes, demonstrating the crucial role of farmer psychology and system-level dynamics in the success or failure of regenerative policies. This underscores the need for tailored, multi-faceted policy approaches in promoting sustainable agriculture.
miR-184 represses β-catenin and behaves as a skin tumor suppressor
Authors: Avitan-Hersh Emily , Turovsky Lubov , Kheshaiboun Ghazal , Yasen Gharam , Nagossa Sara , Boyango Ilanit , Bhattacharya Swarnabh , Amitai-Lange Aya , Ilan Neta , Vlodavsky Israel , aberdam daniel , Shalom-Feuerstein Ruby 
Published: September 2023

Abstract
miR-184-knockout mice display perturbed epidermal stem cell differentiation. However, the potential role of miR-184 in skin pathology is unclear. Here, we report that miR-184 controls epidermal stem cell dynamics and that miR-184 ablation enhances skin carcinogenesis in mice. In agreement, repression of miR-184 in human squamous cell carcinoma (SCC) enhances neoplastic hallmarks of human SCC cells in vitro and tumor development in vivo. Characterization of miR-184-regulatory network, suggests that miR-184 inhibits pro-oncogenic pathways, cell proliferation, and epithelial to mesenchymal transformation. Of note, depletion of miR-184 enhances the levels of β-catenin under homeostasis and following experimental skin carcinogenesis. Finally, the repression of β-catenin by miR-184, inhibits the neoplastic phenotype of SCC cells. Taken together, miR-184 behaves as an epidermal tumor suppressor, and may provide a potentially useful target for skin SCC therapy.
Identification and validation of immune-related lncRNAs-associated prognostic risk model in skin cutaneous melanoma
Authors: Zhang Xiaojing , Chen Xinye 
Published: September 2023

Abstract
Background: Immune infiltration is the key to various diseases and implicated in cancer progression and oncogenesis. However, the potential diagnostic value of immune-related lncRNAs in skin cutaneous melanoma (SKCM) remains unclear.
Methods: Immune-related lncRNAs that were expressed in SKCM samples were investigated using Pearson correlation analysis. The prognostic risk score model was built using the LASSO and univariate and Cox multivariate regressions. The accuracy and prognostic value of risk score were validated by using receiver operating characteristic (ROC) curves, Kaplan-Meier (K-M) survival, univariate and multivariate COX analyses.
Results: 98 lncRNAs had a significant effect on the survival of SKCM patients. The OS rate of SKCM patients with high-risk score was decreased compared to the patients with low-risk score. Our risk model had an accurate diagnose ability for SKCM in the training and testing sets. A nomogram based on age, tumor stage, gender and risk score that had a strong ability to forecast 1-, 2-, 3-, 5-year OS of SKCM patients. In addition, risk score was negatively correlated with infiltration of eight immune cells.
Conclusion: Five immune-related lncRNAs and a prognostic risk score model associated with SKCM prognosis and immune infiltrations might help us evaluate several immune-related targets for SKCM therapy.
Longitudinal evaluation of the distribution of intraretinal hyper-reflective foci in eyes with intermediate age-related macular degeneration
Authors: Sadda Srinivas , Verma Aditya , Corradetti Giulia , Nittala Muneeswar , He Ye , Nassisi Marco , Velaga Swetha Bindu , Haines Jonathan , Pericak-Vance Margaret , Stambolian Dwight 
Published: September 2023

Abstract
Purpose: Intraretinal hyper-reflective foci (IHRF) are optical coherence tomography (OCT) risk factors for progression of age-related macular degeneration (AMD). In this study we assess the change in the number and distribution of IHRF over two years.
Methods: The axial distribution of IHRF were quantified in eyes with intermediate AMD (iAMD) at baseline and 24 months, using a series of 5 sequential equidistant en face OCT retinal slabs generated between the outer border of the internal limiting membrane (ILM) and the inner border of the retinal pigment epithelium (RPE). Following thresholding and binarization, IHRF were quantified in each retinal slab using ImageJ. The change in IHRF number in each slab between baseline and month 24 was calculated.
Results: Fifty-two eyes showed evidence of IHRF at baseline, and all continued to show evidence of IHRF at 24 months (M24). The total average IHRF count/eye increased significantly from 4.67 ± 0.63 at baseline to 11.62 ± 13.86 at M24 (p<0.001) with a mean increase of 6.94 ± 11.12 (range: - 9 to + 60). Overall, at M24, 76.9% eyes showed an increase in IHRF whereas 15.4% of eyes showed a decrease (4 eyes [7.6%] showed no change). There was a greater number of IHRF and a greater increase in IHRF over M24 in the outer slabs.
Conclusions: IHRF are most common in the outer retinal layers and tend to increase in number over time. The impact of the distribution and frequency of these IHRF on the overall progression of AMD requires further study.
Adherence to Legionella control regulations and guidelines in Norwegian nursing homes: a cross-sectional survey
Authors: Bekkelund Anders , Angeloff Line , Amato Ettore , Hyllestad Susanne 
Published: September 2023

Abstract
Background

Infection by Legionella bacteria is a risk to elderly individuals in health care facilities and should be managed by preventing bacterial proliferation in internal water systems. Norwegian legislation calls for a mandatory Legionella-specific risk assessment with the subsequent introduction of an adapted water management programme. The present study investigates adherence to legislation and guidelines on Legionella control and prevention in Norwegian nursing homes.

Methods

A cross-sectional survey was distributed to Norwegian municipalities to investigate the status of Legionella specific risk assessments of internal water distribution systems and the introduction of water management programmes in nursing homes.

Results

A total of 55.1% of the participating nursing homes had performed Legionella-specific risk assessments, of which 55.3% stated that they had updated the risk assessment within the last year. 96.5% introduced a water management programme following a risk assessment, whereas 59.6% of the ones without a risk assessment did the same. Nursing homes with risk assessments were more likely to monitor Legionella levels than those without (61.2% vs 38.8%), to remove dead legs (44.7% vs 16.5%), and to select biocidal preventive treatment over hot water flushing (35.5% vs 4.6%).

Conclusions

This study presents novel insight into Legionella control in Norway, suggesting that adherence to mandatory risk assessment in nursing homes is low. Once performed, the risk assessment seems to be advantageous as an introduction to future Legionella prevention in terms of the scope and contents of the water management programme.
Anterior cruciate ligament femoral side retained stump technique reduces enlargement of the femoral bone tunnel after anterior cruciate ligament reconstruction
Authors: Li Xiaobo , Li Hanlin , Su Jixian , Ding Ran 
Published: September 2023

Abstract
Background Enlargement of the bone tunnel has become an unavoidable early complication after anterior cruciate ligament (ACL) reconstruction, whether it is a single or double-bundle ACL reconstruction. Preservation of the ACL stump in ACL reconstruction reduces enlargement of the bone tunnel. The purpose of this study was to investigate the question of whether single-bundle ACL reconstruction using the ACL femoral side retained stump technique reduces enlargement of the femoral tunnel.Methods Forty patients who underwent single-bundle reconstruction of the ACL were included in this study. The patients were categorized into a Remnant preservation group (Group R) and the Non-remnant preservation group (Group N). In the Remnant preservation group, a high-flexion femoral side retained stump technique was used intraoperatively for the establishment of the femoral side bone tunnel, and in the Non-remnant preservation group, the conventional femoral positioning method was used, and MRI of the operated knee joints was performed at 3 months postoperatively, and the diameters of the femoral bone tunnel were measured in the coronal and axial positions at a point of 5mm away from the inner opening of the femoral bone tunnel. The size of the tunnel was compared between the intraoperative drilling of the bone tunnel and the size of the bone tunnel at 3 months postoperatively. Postoperative clinical assessment was Lysholm score.Results After a 3-month follow-up of 40 patients, the femoral bone tunnel enlargement rate was 22.4 ± 6.5% in the group without ACL femoral side stump preservation (Group N) and 15.1 ± 3.6% in the group with ACL femoral side stump preservation (Group R).Conclusion ACL femoral side retained stump technique in single-bundle ACL reconstruction reduces enlargement of the femoral bone tunnel.