bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curative effect of anti-fibrosis Chinese patent medicines combined with ursodeoxycholic acid for primary biliary cholangitis: A systematic review and meta-analysis
Authors: Bi Yufei , Shi Ke , Chen Jialiang , Wang Xianbo 
Published: March 2023

Objective: To delineate the curative effect and safety of anti-fibrosis Chinese patent medicines (CPMs) combined with ursodeoxycholic acid (UDCA) for primary biliary cholangitis (PBC).Methods: A literature search was conducted using PubMed, Web of Science, Embase, Cochrane Library, Wanfang database, VIP database, China Biology Medicine Database, and Chinese National Knowledge Infrastructure from their inception until August 2022. Randomized controlled trials (RCTs) of the treatment of PBC with anti-fibrotic CPMs were collected. The eligibility of the publications was assessed using the Cochrane risk-of-bias tool. The evaluation indicators were the clinical efficacy rate, liver fibrosis, liver function, immune function, and symptom score. Meta-analysis and subgroup analysis were conducted to evaluate the effectiveness of anti-fibrosis CPMs. Risk ratio (RR) was used to assess dichotomous variables, and continuous variables with a 95% confidence interval were calculated using mean difference.Results: Twenty-two RCTs including 1,725 patients were selected. The findings demonstrated that anti-fibrotic CPMs combined with UDCA improved the efficacy rate, liver function, liver fibrosis, immunological indicators, and clinical symptoms compared with UDCA alone (all p &lt; 0.05).Conclusion: This study demonstrates that the combination of anti-fibrotic CPMs and UDCA can improve both clinical symptoms and outcomes. Nevertheless, more high-quality RCTs are needed to assess the effectiveness of anti-fibrosis CPMs for PBC.
Effect of preoperative radiotherapy on the prognosis of patients with stage cTxN0M0 esophageal squamous cell carcinoma: propensity score matching analysis based on SEER database
Authors: Jin Zixian , Sun Jiajing , Zhang Jian , Shen Jianfei , Zhang Bo 
Published: March 2023

ObjectiveThe aim of this study was to investigate the effect of preoperative radiotherapy (RT) on overall survival (OS) in patients with stage cTxN0M0 esophageal squamous cell carcinoma (ESCC).MethodsA total of 467 patients with ESCC diagnosed as cTxN0M0 and undergoing esophagectomy between 2004 and 2016 were downloaded from the Surveillance, Epidemiology, and End Results (SEER) database. According to the presence or absence of preoperative RT, the patients were divided into preoperative RT group and non-preoperative RT group. Propensity score matching (PSM) was performed to equalize baseline levels between groups. Univariate and multivariate Cox regression analyses were used to compare the survival differences between the two groups.ResultsUsing PSM, 162 pairs of patients were selected. Preoperative RT was not a prognostic factor for OS in all patients with cTx stage. After PSM, for patients with cT1–2 stage, univariate Cox regression analysis showed that preoperative RT was an influencing factor of OS, and multivariate Cox regression analysis confirmed that preoperative RT was an independent predictor of OS. Compared with non-preoperative RT, preoperative RT significantly decreased OS (HR = 1.556, 95%CI 1.008–2.464, p = 0.046). For patients with cT3–4, univariate Cox regression analysis showed that preoperative RT was an influencing factor for OS, and multivariate Cox regression analysis determined that preoperative RT was independent predictors of survival. Compared with non-preoperative RT, preoperative RT significantly improved the OS (HR = 0.479, 95%CI 0.272–0.841, p = 0.010).ConclusionFor ESCC, preoperative RT can improve the OS of patients with cT3-4N0M0. However, preoperative RT is not suitable for patients with cT1-2N0M0.
Evaluating outcomes of patient-centered enhanced recovery after surgery (ERAS) in percutaneous nephrolithotomy for staghorn stones: An initial experience
Authors: Lei Jun , Huang Kai , Dai Yingbo , Yin Guangming 
Published: March 2023

ObjectiveTo evaluate the outcomes of patient-centered enhanced recovery after surgery (ERAS) in ­percutaneous nephrolithotomy (PCNL) for staghorn stones.Patients and methodsA retrospective analysis of 106 patients with staghorn calculi who underwent PCNL treatment at the Third Xiangya Hospital from October 01, 2018 to September 30, 2021 was performed. The patients were divided into the ERAS group (n = 56) and traditional group (n = 50). The ERAS program focused on a patient-centered concept, with elaboration on aspects, such as patient education, nutritional support, analgesia, body warming, early mobilization, nephrostomy tube removal, and strict follow-up.ResultsThe total stone free rate and total complication rate were similar in both groups. The visual analogue scale (VAS) 6 h after surgery, ambulation off bed time, indwelling ﬁstula time, indwelling catheter time, and postoperative hospital stays were lower in the ERAS group than in the traditional group (P &lt; 0.05). The multiple session rate in the ERAS group (19, 28.57%) was lower than that in the traditional group (30, 60%) (P = 0.007). The 1-year stone recurrence rate in the ERAS group (7, 17.5%) was lower than that in the traditional group (14, 38.9%) (P = 0.037).ConclusionThe patient-centered ERAS in PCNL for staghorn stones accelerated rehabilitation by relieving postoperative pain, shortening hospitalization time, accelerating early ambulation, and reducing multiple session rate and 1-year stone recurrence rate, which have socioeconomic benefits.
Developmental venous anomaly associated with dural arteriovenous fistula: Etiopathogenesis and hemorrhagic risk
Authors: Agosti Edoardo , De Maria Lucio , Panciani Pier Paolo , Serioli Simona , Mardighian Dikran , Fontanella Marco Maria , Lanzino Giuseppe 
Published: March 2023

IntroductionDevelopmental venous anomalies (DVAs) have traditionally been defined as non-pathological congenital lesions. Compared to isolated DVAs, the association of DVAs with arteriovenous shunts seems to have a more adverse clinical connotation. In this review, we describe the association between DVA and dAVF and discuss the hemorrhagic risk. We also advance a hypothesis about the potential de novo formation of a DVA and challenge the dogma about their “developmental” or “congenital” nature.MethodsA systematic review of the literature on the association of DVA and dAVF was performed in accordance with the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines.ResultsA number of 678 papers was initially identified, but only 9 studies were included in the final qualitative analysis. Most of the patients presented with bleeding (56%), with a median GCS of 14 (range 10–15). In 56% of the cases the DVA had a supratentorial location. Supratentorial DVAs mostly drained in the superior sagittal sinus (80%), while all of infratentorial/combined DVAs drained in deep ependymal veins of the 4th ventricle. All the supratentorial dAVFs drained into the superior sagittal sinus, while the infratentorial/combined dAVFs mostly drained in the jugular bulb, Vein of Rosenthal, or transverse-sigmoid sinuses (75%). Most of the dAVFs were classified as Cognard type IIa + b (67%), while in a smaller number of cases type I (22%) and type V (11%). The dAVF was the target of treatment in each case and most patients underwent endovascular treatment (78%). The dAVF was completely occluded in 78% of cases and no periprocedural complications were reported.ConclusionThe clinical presentation, radiological findings, and treatment outcomes of DVAs and associated dAVFs have been discussed. Despite the general opinion that DVAs are benign congenital lesions, increasing epidemiological and radiological evidence supports a potential acquired origin, and the venous system seem to play a pivotal role in their post-natal genesis and development.
Grading pharmacists’ risk of complaints to a regulator: A retrospective cohort study
Authors: Morris Katherine , Spittal Matthew J. 
Published: March 2023

Background: Tools to grade risk of complaint to a regulatory board have been developed for physicians but not for other health practitioner groups, including pharmacists. We aimed to develop a score that classified pharmacists into low, medium and high risk categories.Methods: Registration and complaint data were sourced from Ontario College of Pharmacists for January 2009 to December 2019. We undertook recurrent event survival analysis to predict lodgement of a complaint. We identified those variables that were associated with a complaint and included these in a risk score which we called PRONE-Pharm (Predicted Risk of New Event for Pharmacists). We assessed diagnostic accuracy and used this to identify thresholds that defined low, medium and high risk.Results: We identified 3,675 complaints against 17,308 pharmacists. Being male (HR = 1.72), older age (HR range 1.43–1.54), trained internationally (HR = 1.62), ≥1 prior complaint (HR range 2.83–9.60), and complaints about mental health or substance use (HR = 1.91), compliance with conditions (HR = 1.86), fees and servicing (HR = 1.74), interpersonal behaviour or honesty (HR = 1.40), procedures (HR = 1.75) and treatment or communication or other clinical issues (HR = 1.22) were all associated with lodgement of a complaint. When converted into the PRONE-Pharm risk score, pharmacists were assigned between 0 and 98 points with higher scores closely associated with higher probability of a complaint. A score of ≥25 had sufficient accuracy for classifying medium-risk pharmacists (specificity = 87.0%) and ≥45 for high-risk pharmacists (specificity = 98.4%).Conclusion: Distinguishing isolated incidents from persistent problems poses a significant challenge for entities responsible for the regulation of pharmacists and other health practitioners. The diagnostic properties of PRONE-Pharm (minimizing the false positives) means that the risk score is useful for “ruling-out” low risk pharmacists using routinely collected regulatory data. PRONE-Pharm may be useful when used alongside interventions appropriately matched to a pharmacist’s level of risk.
Conjoining Trees for the Provision of Living Architecture in Future Cities: A Long-Term Inosculation Study
Authors: Mylo Max D. , Ludwig Ferdinand , Rahman Mohammad A. , Shu Qiguan , Fleckenstein Christoph , Speck Thomas , Speck Olga 
Published: March 2023

Faced with the environmental challenges posed by climate change, architects are creating nature-based solutions for urban areas, such as transforming living trees into artificial architectural structures. In this study, we have analyzed stem pairs of five tree species conjoined for more than eight years by measuring the stem diameters below and above the resulting inosculation and by calculating the respective diameter ratio. Our statistical analyses reveal that Platanus × hispanica and Salix alba stems do not differ significantly in diameter below inosculation. However, in contrast to P. × hispanica, the diameters of the conjoined stems above inosculation differ significantly in S. alba. We provide a binary decision tree based on diameter comparisons above and below inosculation as a straightforward tool for identifying the likelihood of full inosculation with water exchange. Moreover, we have compared branch junctions and inosculations by means of anatomical analyses, micro-computed tomography, and 3D reconstructions showing similarities in the formation of common annual rings that increase the capacity for water exchange. Due to the highly irregular cell arrangement in the center of the inosculations, cells cannot be assigned clearly to either of the stems. In contrast, cells in the center of branch junctions can always be attributed to one of the branches.
Areas of Endemism of Plants in the South-Central and Southwestern Nearctic Region
Authors: Saghatelyan Anna , Escalante Tania 
Published: March 2023

The history and connections of the flora of south-central/southwestern (SC/SW) North America have been studied and summarized in biogeographic regionalization. However, some studies show contrasting delineations of the SC/SW North American provinces that could be better determined using quantitative methods. We aimed to find spatial patterns of a set of plants in the SC/SW United States by conducting endemicity analysis (EA) on different scales. We first built a dataset with 81,965 specimen point records of 400 species from 174 genera and 61 families of angiosperms and two genera of gymnosperms using digitized specimen data from iDigBio. We then performed EA at four different scales to identify the areas of endemism (AoEs).
We obtained 28 AoEs with different cell sizes by selecting each AoE under the grid size that yielded the highest number of high-scoring species. The study region split into two significant centers of accumulation of nested or partially overlapping AoEs: the SW and SC consensus areas. In these parts of the Nearctic region, many genera/clades, among those in the dataset, showed a geographic split into western and eastern clades. The split corresponded to an environmental and physical barrier known as Cochise Filter Barrier. The Sonora–Mojave arid center, parts of South Texas, and the Chihuahuan Desert harbor basally branching taxa of several genera and even families, based on the observations of some species, which allowed identification of the AoEs.
Analisis Strategi Pemasaran Cemilan Kacang Tanah (Arachis Hypogaea) Studi Kasus Pada Home Industry Rapo-Rapo Di Kota Raha Kabupaten Muna
Authors: Alzarliani Waode , Edy Safrin , Takdir Takdir 
Published: March 2023

Penelitian ini bertujuan: untuk mengetahui kelemahan, kekuatan, peluang dan ancaman yang mempengaruhi pemasaran cemilan kacang tanah (Arachis hypogaea) pada Home Industry Rapo-Rapo di Kota Raha Kabupaten Muna serta untuk merumuskan strategi pemasaran yang sesuai untuk diterapkan pada Home Industry Rapo-Rapo cemilan kacang tanah di Kota Raha Kabupaten Muna.
Penelitian ini dilakukan pada bulan Maret 2021 di Home Industry Rapo-Rapo, Kota Raha, Kabupaten Muna. Sampel dalam penelitian ini adalah pelaku usaha Home Industry Rapo-Rapo cemilan kacang tanah. Metode yang digunakan adalah analisis strategi pemasaran, analisis faktor internal dan eksternal melalui analisis SWOT dan analisis deskriptif kualitatif.
Hasil penelitian menunjukan bahwa berdasarkan matriks SWOT maka prioritas utama startegi pada Home Industry Rapo-Rapo cemilan kacang tanah di Kota Raha Kabupaten Muna adalah berada pada kuadran I (Progresif), yaitu Strategi S-O (Strength-Opportunity) atau strategi kekuatan-peluang “Daya guna Home Industry Rapo-Rapo cemilan kacang tanah yang memiliki status usaha sendiri, memiliki kemasan prodak yang sudah memenuhi standar menyebabkan Rapo-Rapo cemilan kacang tanah berkualitas sangat baik, dalam merebut dan menciptakan peluang inovasi bentuk produk, dan produk sudah dikenal sebagai oleh-oleh melalui penggunaan media sosial sebagai media pemasaran".
Dampak Perubahan Iklim Terhadap Produktivitas Kopi Robusta Di Desa Kurrak Kecamatan Tapango Kabupaten Polewali Mandar
Authors: Angka Andi Werawe Awe 
Published: March 2023

The production of the local coffee plantation contributes significantly to the national coffee production. The effort in providing production inputs and plantation maintenance has been performed but the optimum productivity has not been achieved yet. The productivity of robusta coffee plantation that depends on the rainwater harvesting can be affected by microenvironment climate changes such as the temperature increase and the rainfall intensity. This research was conducted in the Kurrak Village, Tapango District, Polewali Mandar Regency. The research sample was the robusta coffee farmers who cultivate the young coffee plants. The research method used was a descriptive quantitative study using multiple linear regression for data analysis. The regression results show that temperature and precipitation significantly affected the productivity of Robusta coffee in the Kurrak Village, Tapango District, Polewali Mandar Regency. The impact of climate change affects the growth of robusta coffee and the shift of the cultivation activity time.
Keywords: Productivity, Robusta Coffee, Climate Change

ABSTRAK

Produksi perkebunan kopi rakyat berkontribusi besar bagi produksi kopi nasional. Upaya pemberian input produksi dan pemeliharaan kebun telah dilakukan namun produktivitas belum mencapai optimal. Produktivitas kebun kopi robusta yang bergantung pada tadah hujan dapat dipengaruhi oleh dampak perubahan iklim pada lingkungan mikro yaitu kenaikan suhu dan intensitas curah hujan. Penelitian ini dilaksanakan di Desa Kurrak, Kecamatan Tapango Kabupaten Polewali Mandar. Sampel penelitian adalah petani kopi robusta yang mengusahakan tanaman kopi umur muda. Metode penelitian yang digunakan adalah deskriptif kuantitatif. dengan nalisis data regresi linear berganda. Hasil regresi menunjukkan bahwa suhu dan curah hujan berpengaruh nyata terhadap produktivitas kopi Robusta di Desa Kurrak Kecamatan Tapango Kabupaten Polewali Mandar. Dampak perubahan iklim secara kompleks berpengaruh pada pengembangan kopi robusta dan pergeseran waktu aktivitas budidaya.
Kata Kunci: Produktivitas, Kopi Robusta, Perubahan iklim
Analisis Tingkat Potensi Berswasembada Pangan Kabupaten Lombok Tengah Provinsi NTB
Authors: Ayu Candra , Wuryantoro Wuryantoro , Nursan Muhammad 
Published: March 2023

Kabupaten Lombok Tengah merupakan sentra produksi pangan, khususnya beras di Propinsi NTB. Namun potensi untuk berswasembada pangan tersebut terancam akibat alih fungsi lahan untuk aktivitas di luar pertanian. Penelitian ini menggunakan data sekunder terakhir yang tersedia (tahun 2019 dan 2020) untuk menganalisis di tingkat kecamatan dan tingkat kabupaten (Kabupaten Lombok Tengah) tentang: luas tanam tanaman pangan/kapita/tahun, luas lahan minimal/kapita/tahun untuk mencapai swasembada pangan; jumlah produksi tanaman pangan dan menentukan tingkat potensi berswasembada pangan setiap kecamatan di Kabupaten Lombok Tengah. Hasil penelitian menunjukkan bahwa luas tanam tanaman pangan per kapita tahun 2020 di Kabupaten Lombok Tengah sebesar 216,67 % dari lahan minimal untuk berswasembada pangan (minimal 0,06 ha/kapita/tahun); tersempit di Kecamatan Praya dan terluas di Kecamatan Praya Barat Daya. Jumlah produksi tanaman pangan setara kalori 2.208.837.325.200 Kilo kalori atau setara 613.565.924 kg beras/tahun. Kecamatan dengan potensi daya dukung berswasembada pangan tinggi (mampu berswasembada pangan dan memberi kehidupan layak) adalah Praya Barat Daya, Pujut, Praya Timur dan Praya Barat; sedangkan yang berdaya dukung sedang (mampu berswasembada minimal sejumlah Kebutuhan Fisik Minimum tapi kehidupan belum layak) adalah kecamatan: Jonggat, Janapria, Praya Tengah, Kopang, Batukliang Utara, Pringgarata, Batukliang, dan Praya. Kecamatan Praya merupakan wilayah yang paling rawan mengalami penurunan potensi berswasembada pangan menjadi rendah akibat dari tingginya laju pembangunan ekonomi dan pertambahan penduduk yang mengkonversi lahan pertanian produktif.
Strategi Pengembangan Jeruk Manis Di Kecamatan Siompu Kabupaten Buton Selatan
Authors: Suriadi Suriadi , Jasiyah Rabiyatul , Kasman La 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui strategi pengembangan jeruk manis di Desa Waindawula Kecamatan Siompu Kabupaten Buton Selatan. Sampel dalam penelitian ini adalah seluruh petani jeruk manis sebanyak 20 orang. Metode analisis data menggunakan analisi matriks Strength, Weakness, Opportunities, dan Threat.
Hasil penelitian menunjukan bahwa strategi yang baik berada pada kuadran I menandakan keadaan yang sangat bermanfaat mempunyai peluang dan kekuatan untuk mendukung metode perkembangan yang agresif (cenderung, kebutuhan) dan pada matriks SWOT menerapkan strategi S-O yaitu adanya kesediaan lahan yang masih luas sehingga petani dapat memperoleh produksi yang tinggi dengan meningkatkan budidaya jeruk manis, adanya SDM anggota keluarga sendiri agar dapat dimanfaatkan sebagai tenaga kerja untuk proses penjualan jeruk manis melalui media sosial, adanya pengetahuan dan keterampilan petani sehingga menghasilkan jeruk manis yang berkualitas, dan petani dapat mempromosikan hasil jeruk manis karena mempunyai cita rasa yang khas sehingga mampu dikenal oleh masyarakat secara umum. Kemudian hasil analisis data dalam matriks SWOT menerapkan strategi S-O yaitu dengan total skor 3.69. Adapun dalam matriks IFAS memiliki total skor kekuatan 1.97 dan total skor kelemahan 0.5 sedangkan dalam matriks EFAS memiliki total skor peluang 1.72 dan total skor ancaman 0.56.
Evaluasi Model Akselerasi Swasembada Kedelai di Lahan Kering Kabupaten Lombok Tengah
Authors: Ayu Candra , Wuryantoro Wuryantoro , Mundiyah Andi Iva 
Published: March 2023

Kabupaten Lombok Tengah yang didominasi pertanian lahan kering menjadi sentra produksi kedelai kedua di tingkat provinsi, namun, petani di Lombok Tengah kurang berminat menanam kedelai karena merugikan. Kondisi ini menurunkan jumlah produksi kedelai dan menguatkan ketergantungan terhadap kedelai impor. Penelitian ini bertujuan untuk mengevaluasi model akselerasi swasembada kedelai di wilayah pertanian lahan kering Kabupaten Lombok Tengah. Uji coba model pada kelompok masyarakat binaan bertujuan menilai ketepatan peran dan interaksi komponen-komponen model untuk mempercepat pencapaian swasembada kedelai di Lombok Tengah. Sentra uji coba model adalah pengembangan agroindustri berbasis kedelai karena menciptakan nilai tambah yang mensejahterakan keluarga petani menjadi insentif kuat bagi petani sehingga menimbulkan minat berusahatani kedelai. Pengembangan model dapat membuka lapangan kerja baru di bidang pemasaran input-output usahatani dan agroindustry dan diperolehnya pendapatan sepanjang tahun. Manfaat ekonomi tersebut semakin menguatkan kualitas pengelolaan usahatani kedelai oleh petani sehingga terjadi akselerasi swasembada kedelai khususnya di Kabupaten Lombok Tengah.
DIMENSION OF SERVICE QUALITY (RATER) ON CONSUMER SATISFACTION
Authors: Ahmad Farhani  
Published: March 2023

This study aims to examine the Dimensions of Service Quality (RATER) on Consumer Satisfaction in the building shop owned by Mr. H. Ijul in Tabalong Regency. The tight competition in the world of trade requires business actors to have a competitive and sustainable advantage, business actors must have the right marketing strategy, one of which is paying attention to factors that can provide maximum satisfaction to their consumers.
This study uses 5 exogenous variables, namely, reliability, assurance, tangible, empathy responsiveness, while the endogenous variable is customer satisfaction. Sampling was done by purposive sampling totaling 166 respondents. The data analysis technique used Variance Based SEM (PLS-SEM) with SmartPLS 3.29 software. The results showed that the responsiveness, reliability, assurance and tangible variables had a positive and significant effect on consumer satisfaction, while the empathy variable had a negative and insignificant effect on consumer satisfaction. The implication must be good management in changing its strategy by maximizing indicators on reliability, assurance, tangible empathy. Responsiveness provided by the store to consumers
Keywords: Dimensions of Service Quality; RATER ; Store building ; SEM ; SmartPLS ; Consumer Satisfaction