bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weekend effect on 30-day mortality for ischemic and hemorrhagic stroke analyzed using severity index and staffing level
Authors: Kim Seung Bin , Lee Bo Mi , Park Joo Won , Kwak Mi Young , Jang Won Mo 
Published: June 2023

Background and purpose
Previous studies on the weekend effect—a phenomenon where stroke outcomes differ depending on whether the stroke occurred on a weekend—mostly targeted ischemic stroke and showed inconsistent results. Thus, we investigated the weekend effect on 30-day mortality in patients with ischemic or hemorrhagic stroke considering the confounding effect of stroke severity and staffing level.

Methods
We retrospectively analyzed data of patients hospitalized for ischemic or hemorrhagic stroke between January 1, 2015, and December 31, 2018, which were extracted from the claims database of the National Health Insurance System and the Medical Resource Report by the Health Insurance Review & Assessment Service. The primary outcome measure was 30-day all-cause mortality.

Results
In total, 278,632 patients were included, among whom 84,240 and 194,392 had a hemorrhagic and ischemic stroke, respectively, with 25.8% and 25.1% of patients, respectively, being hospitalized during the weekend. Patients admitted on weekends had significantly higher 30-day mortality rates (hemorrhagic stroke 16.84%>15.55%, p<0.0001; ischemic stroke 5.06%>4.92%, p<0.0001). However, in the multi-level logistic regression analysis adjusted for case-mix, pre-hospital, and hospital level factors, the weekend effect remained consistent in patients with hemorrhagic stroke (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.00–1.10), while the association was no longer evident in patients with ischemic stroke (OR 1.01, 95% CI 0.96–1.06).

Conclusions
Weekend admission for hemorrhagic stroke was significantly associated with a higher mortality rate after adjusting for confounding factors. Further studies are required to understand factors contributing to mortality during weekend admission.
Long non-coding RNAs CCAT1 and CCAT2 in colorectal liver metastases are tumor-suppressive via MYC interaction and might predict patient outcomes
Authors: Franz Clemens , Wuehrl Michael , Hartmann Sibylle , Klupp Fee , Schmidt Thomas , Schneider Martin 
Published: June 2023

Background
Liver metastases severely reduce the long term survival of colorectal cancer patients. Long non-coding RNAs (lncRNAs) CCAT1 and CCAT2 have previously been found to be associated with impaired patient outcomes in primary colorectal cancer. We aimed to elucidate the role of CCAT1 and CCAT2 in colorectal liver metastases.

Methods
Total RNA was isolated from 97 human tissue samples of colorectal liver metastases and adjacent normal liver tissue. Gene expression analysis was performed by RT-qPCR and Multiplex ELISA and correlated with patient characteristics and survival. Gene expression, cancer cell migration, invasion, and proliferation were studied after siRNA-mediated knockdown of CCAT1, CCAT2, and MYC in metastatic colorectal cancer cell lines Colo205 and HROC277Met2.

Results
Elevated expression levels of lncRNAs CCAT1 and CCAT2, and their common target MYC in colorectal liver metastases were associated with prolonged progression-free survival after liver resection. High expression of CCAT1 was likewise associated with prolonged overall survival. Knockdown of CCAT1, CCAT2, and MYC resulted in increased migratory and invasive potential in metastatic colorectal cancer cell lines. Gene expression analysis revealed alterations in constituents of Wnt signaling following knockdown.

Conclusion
Our findings demonstrate tumor-suppressive functions of lncRNAs CCAT1 and CCAT2 in colorectal liver metastases. They suppress Wnt signaling directly and indirectly through target gene MYC and might prevent further metastatic spread from colorectal liver metastases.
Qualitative evaluation of barriers and facilitators to hepatocellular carcinoma care in North Carolina
Authors: Ray Emily M. , Teal Randall W. , Carda-Auten Jessica , Coffman Erin , Sanoff Hanna K. 
Published: June 2023

Background
Many patients with hepatocellular carcinoma (HCC) never receive cancer-directed therapy. In order to tailor interventions to increase access to appropriate therapy, we sought to understand the barriers and facilitators to HCC care.

Methods
Patients with recently diagnosed HCC were identified through the University of North Carolina (UNC) HCC clinic or local hospital cancer registrars (rapid case ascertainment, RCA). Two qualitative researchers conducted in-depth, semi-structured interviews. Interviews were audiotaped, transcribed, and coded.

Results
Nineteen interviews were conducted (10 UNC, 9 RCA). Key facilitators of care were: physician knowledge; effective communication regarding test results, plan of care, and prognosis; social support; and financial support. Barriers included: lack of transportation; cost of care; provider lack of knowledge about HCC; delays in scheduling; or poor communication with the medical team. Participants suggested better coordination of appointments and having a primary contact within the healthcare team.

Limitations
We primarily captured the perspectives of those HCC patients who, despite the challenges they describe, were ultimately able to receive HCC care.

Conclusions
This study identifies key facilitators and barriers to accessing care for HCC in North Carolina. Use of the RCA system to identify patients from a variety of settings, treated and untreated, enabled us to capture a broad range of perspectives. Reducing barriers through improving communication and care coordination, assisting with out-of-pocket costs, and engaging caregivers and other medical providers may improve access. This study should serve as the basis for tailored interventions aimed at improving access to appropriate, life-prolonging care for patients with HCC.
Increased patient satisfaction by integration of palliative care into geriatrics—A prospective cohort study
Authors: Schelin Maria E. C. , Fürst Carl Johan , Rasmussen Birgit H. , Hedman Christel 
Published: June 2023

Background
Integration of oncology and palliative care has been shown to increase quality of life in advanced disease. To meet the needs of the growing older population, integration of palliative care and geriatrics has been proposed but scarcely described.

Objectives
The aim of this study was to integrate palliative care into geriatrics by a structured care guide, the Swedish Palliative Care Guide, and to evaluate its effect on patient satisfaction, health-related quality of life and symptom burden, compared to a control group.

Methods
Geriatric in-patients over 65 years of age were included in the study, those with cognitive impairment were excluded. Data was collected before (baseline) and after the implementation (intervention) of the Swedish Palliative Care Guide. Patient satisfaction was evaluated two weeks after discharge with questions from a national patient survey. Health-related quality of life was measured with EQ-5D-3L and symptom burden with Edmonton Symptom Assessment Scale.

Results
In total, 400 patients were included, 200 in the baseline- and intervention group, respectively. Mean age was 83 years in both groups. Patient satisfaction was significantly higher in nine out of ten questions (p = 0.02-<0.001) in the intervention group compared to baseline. No differences between the groups were seen in health-related quality of life or symptom burden.

Conclusion
A significant effect on patient satisfaction was seen after implementation of the Swedish Palliative Care Guide in geriatric care. Thus, integration of palliative care and geriatrics could be of substantial benefit in the growing population of older adults with multimorbidity and frailty.
Cerebral blood flow autoregulation assessment by correlation analysis between mean arterial blood pressure and transcranial doppler sonography or near infrared spectroscopy is different: A pilot study
Authors: Thudium Marcus , Moestl Stefan , Hoffmann Fabian , Hoff Alex , Kornilov Evgeniya , Heusser Karsten , Tank Jens , Soehle Martin 
Published: June 2023

Purpose
Recently, cerebral autoregulation indices based on moving correlation indices between mean arterial pressure (MAP) and cerebral oximetry (NIRS, ORx) or transcranial Doppler (TCD)-derived middle cerebral artery flow velocity (Mx) have been introduced to clinical practice. In a pilot study, we aimed to evaluate the validity of these indices using incremental lower body negative pressure (LBNP) until presyncope representing beginning cerebral hypoperfusion as well as lower body positive pressure (LBPP) with added mild hypoxia to induce cerebral hyperperfusion in healthy subjects.

Methods
Five male subjects received continuous hemodynamic, TCD and NIRS monitoring. Decreasing levels of LBNP were applied in 5-minute steps until subjects reached presyncope. Increasing levels of LBPP were applied stepwise up to 20 or 25 mmHg. Normobaric hypoxia was added until an oxygen saturation of 84% was reached. This was continued for 10 minutes. ORx and Mx indices were calculated using previously described methods.

Results
Both Indices showed an increase > 0.3 indicating impaired cerebral autoregulation during presyncope. However, there was no significant difference in Mx at presyncope compared to baseline (p = 0.168). Mean arterial pressure and cardiac output decreased only in presyncope, while stroke volume was decreased at the last pressure level. Neither Mx nor ORx showed significant changes during LBPP or hypoxia. Agreement between Mx and ORx was poor during the LBNP and LBPP experiments (R2 = 0.001, p = 0.3339).

Conclusion
Mx and ORx represent impaired cerebral autoregulation, but in Mx this may not be distinguished sufficiently from baseline. LBPP and hypoxia are insufficient to reach the upper limit of cerebral autoregulation as indicated by Mx and ORx.
La formación como principio y fin de la acción preventiva frente a los riesgos psicosociales derivados de la digitalización y la automatización
Authors: Megino Fernández Diego 
Published: June 2023

Sin duda, fenómenos como los de la automatización y la digitalización traen consigo elocuentes ventajas, también en el ámbito de las organizaciones productivas. Sin embargo, al mismo tiempo suponen fuentes de potenciales amenazas para la salud laboral de las personas trabajadoras. Entre ellas, corresponde llamar la atención sobre su capacidad para generar inéditos factores de riesgo psicosocial (o, al menos, para agudizar o remozar otros ya arraigados).
Para combatirlos, la disciplina preventiva ha de representar un papel primordial. En especial, las circunstancias demandan un superior protagonismo de la parcela formativa. Unas acciones de adiestramiento bien diseñadas, dirigidas y aplicadas conducirán a actividades y entornos profesionales no solo seguros, sino también saludables.
Por eso, el propósito fundamental de este estudio es el de reflexionar acerca de la relevancia adquirida por la formación en materia preventiva ante los factores de riesgo psicosocial, presentes y futuros, asociados a la contemporánea «cuarta revolución industrial».
Penemuan Hukum oleh Hakim di Indonesia
Authors: Suparno Suparno , Jalil Abdul 
Published: June 2023

Abstract This paper aims to determine the legal findings by judges in Indonesia, both normatively, sociologically, and empirically. The first issue raised is: how is the process of law enforcement by judges in court? Second, what factors influence law enforcement by the judge? This study uses an empirical juridical approach. Law enforcement carried out by judges in court, both at the Constitutional Court and the District Court, still pays attention to the juridical aspect, but the judge also pays attention to the social aspect or social values that apply in society (sociological aspect). These two aspects are combined in order to realize a substantial value of justice. The factors that influence law enforcement in court are: a. Applicable law; b. Community culture, namely social and moral values contained in society; c. The law enforcer, in this case the judge. Judges' views on the law; d. The perpetrator is a person who violates the law, in this case the behavior of the perpetrator is known, especially during the trial and in the community.Keywords: rechtsfinding; judge; justice.AbstrakTulisan ini bertujuan untuk mengetahui penemuan hukum oleh hakim di Indonesia, baik secara normatif, sosiologis, dan empiris. Permasalahan pertama yang diangkat adalah: bagaimana proses penegakan hukum oleh hakim di pengadilan? Kedua, faktor-faktor apakah yang mempengaruhi penegakan hukum oleh hakim tersebut? Penelitian ini mengunakan metode pendekatan yuridis empiris. Penegakan hukum yang dilakukan hakim di pengadilan baik di Mahkamah Konstitusi maupun Pengadilan Negeri tetap memperhatikan aspek yuridis, namun hakim juga memperhatikan aspek sosial atau nilai-nilai sosial yang berlaku di masyarakat (aspek sosiologis). Kedua aspek tersebut dipadukan dalam rangka mewujudkan nilai keadilan yang substansial. Faktor-faktor yang mempengaruhi dalam penegakan hukum di pengadilan yaitu: a. Hukum yang berlaku; b. Kultur masyarakat yaitu nilai-nilai sosial dan moral yang terdapat dalam masyarakat; c. Penegak Hukumnya, dalam hal ini hakim. Pandangan-pandangan hakim tentang hukum; d. Pelaku yaitu orang yang melakukan pelanggaran hukum, dalam hal ini perilaku-perilaku dari pelaku yang diketahui terutama selama persidangan maupun di masyarakat. Kata Kunci: penemuan hukum; hakim; keadilan.
Analisis Dasar Pertimbangan Hakim Tentang Pelanggaran Hak Ekonomi Penggandaan Fiksasi Siaran (Studi Putusan Nomor 724/PID.SUS/2020/PN.BDG)
Authors: Maharani Arnita Febi , Santoso Budi 
Published: June 2023

AbstrakPenelitian ini bertujuan untuk menganalisis dasar pertimbangan hakim dalam memutus perkara tentang pelanggaran hak ekonomi dalam kasus penggandaan fiksasi siaran dalam Putusan Pengadilan Negeri Bandung Nomor 724/Pid.Sus/2020/PN.Bdg. Metode pendekatan penelitian dalam penelitian ini adalah yuridis doktrinal. Penelitian ini bersifat deskriptif analitis yang bersumber data dari sumber data sekunder. Data yang telah didapatkan dianalisis secara kualitatif. Hasil penelitian menunjukkan, bahwa terdakwa melakukan tindakan tersebut semata-mata untuk kepentingannya sendiri dalam mendapatkan manfaat ekonomi, sedangkan PT Global Media Visual sudah mengupayakan perlindungan secara preventif maupun represif selaku pemegang hak cipta sepak bola Liga Inggris musim 2019-2020. Berdasarkan fakta hukum yang terungkap dalam persidangan, menurut analisis penulis telah memenuhi rumusan dalam ketentuan Undang-Undang Nomor 28 Tahun 2014 tentang Hak Cipta, karena terdakwa sadar akan akibat hukum yang terjadi apabila bukan sebagai pemegang hak cipta yang sah. AbstractThis study aims to analyze the basis of judges' considerations in deciding cases regarding violations of economic rights in the case of broadcast fixation doubling in the Bandung District Court Decision Number 724/Pid.Sus/2020/PN.Bdg. The research approach method in this research is doctrinal juridical. This research is a descriptive analytical research that is sourced from secondary data sources. The data that has been obtained were analyzed qualitatively. The results of the study indicate that the defendant took this action solely for his own interests in obtaining economic benefits, while PT Global Media Visual has sought preventive and repressive protection as the copyright holder of the 2019-2020 English League football season. Based on the legal facts revealed in the trial, according to the author's analysis, he has fulfilled the formulation in the provisions of Law Number 28 of 2014 concerning Copyright, because the defendant is aware of the legal consequences that occur if he is not the legal copyright holder.
Program Asimilasi Dan Integrasi Kepada Anak Didik Pemasyarakatan Saat Pandemi Covid-19 (Studi Kasus di Lembaga Pembinaan Khusus Anak Kelas I Kutoarjo)
Authors: Trimiyati Rizqi Mely , Subroto Mitro 
Published: June 2023

Efforts tried by the Indonesian government in carrying out the handling of Covid-19 widely. As one of the implementations that are being tried to prevent the formation of the spread of Covid-19, which is being tried by the Child Special Guidance Agency (LPKA). The issuance of the Regulation of the Minister of Law and Human Rights Number 43 of 2021 concerning the Second Substitution of the Minister of Law and Human Rights Number 32 of 2020 concerning Provisions and Methods for Providing Assimilation, Conditional Release, Leave Before Liability and Conditional Leave for Convicts and Children in the Context of Deterring and Overcoming the Spread of Covid-19. The issuance of regulations This creates pros and cons between the community. In this case, people are worried about the increase in the crime rate. The implementation of Minister of Law and Human Rights Number 43 of 2021 at the Kutoarjo Class I Children's Special Guidance Institute as many as 9 correctional students as of January 2022, in its implementation has negative and positive consequences. The provision of assimilation and integration programs at the Kutoarjo Class I Children's Special Guidance Institute has succeeded in reducing overcrowding, saving pay and increasing children's productivity. Keywords: Assimilation; Integration; Correctional Students Abstrak Upaya yang dicoba oleh pemerintah Indonesia dalam melaksanakan penanggulangan Covid- 19 secara meluas. Selaku salah satu implementasi yang dicoba buat melaksanakan penangkalan terbentuknya penyebaran Covid- 19 yang dicoba oleh Lembaga Pembinaan Khusus Anak (LPKA). Dikeluarkannya peraturan Permenkumham Nomor 43 Tahun 2021 Tentang Perubahan Kedua Atas Permenkumham Nomor 32 Tahun 2020 Tentang Ketentuan Serta Tata Cara Pemberian Asimilasi, Pembebasan Bersyarat, Cuti Menjelang Bebas Serta Cuti Bersyarat Untuk Narapidana Serta Anak Dalam Rangka Penangkalan Serta Penanggulangan Penyebaran Covid- 19. Adanya dikeluarkannya peraturan tersebut mengakitabkan pro dan kontra diantara masyarakat. Dimanya masyarakat timbul rasa khawair akan meningkatnya angka kriminalitas. Pelakasnaan Permenkumham Nomor 43 Tahun 2021 di Lembaga Pembinaan Khusus Anak Kelas I Kutoarjo sebanyak 9 anak didik pemasyarakatan per Januari 2022, dalam pelaksanaannya mempunyai akibat negatif dan positif yang ditimbulkan tersebut. Pemberian program asimilasi serta integrasi di Lembaga Pembinaan Khusus Anak Kelas I Kutoarjo, sukses kurangi kepadatan, mengirit bayaran dan tingkatkan produktivitas anak. Kata Kunci: Asimilasi; Integrasi; Anak Didik Pemasyarakatan
Penegakan Hukum Terhadap Pemalsu Identitas Dokter Dalam Perspektif Keadilan
Authors: Widasari Widodo Aristia Pradita , Ardiansah Ardiansah , Fahmi Sudi 
Published: June 2023

This study aims to examine the problem of doctor identity counterfeiters and analyze law enforcement against doctor's identity counterfeiters according to positive law in force in Indonesia. This study uses a normative juridical research method using secondary data. The results of the study show that law enforcement against doctor's identity counterfeiters is based on RI Law Number 29 of 2004 concerning Medical Practice, RI Law Number 36 of 2014 concerning Health Workers, RI Law Number 8 of 1999 concerning Consumer Protection, and the Book of the Republic of Indonesia. Criminal Law Act. In these laws and regulations there are regulations that prohibit the use of identities that give the impression of being a doctor as well as criminal threats for perpetrators of counterfeiting. Meanwhile, in law enforcement cases of falsification of doctors' identities in Indonesia, it is felt that it is not appropriate according to the perspective of justice. The conclusion of the study is that law enforcement against doctor's identity counterfeiters has been carried out based on the relevant legislation. However, the application of sanctions that are not fully based on the applicable laws and regulations and do not contain the principles of justice Keywords: Justice; Identity Forgers; Law enforcement. Abstrak Penelitian ini bertujuan untuk mengkaji permasalahan tentang pemalsu identitas dokter dan menganalisa penegakan hukum terhadap pemalsu identitas dokter menurut hukum positif yang berlaku di Indonesia. Penelitian ini menggunakan metode penelitian yuridis normatif menggunakan data sekunder. Hasil penelitian menunjukan bahwa penegakan hukum terhadap pemalsu identitas dokter didasarkan pada Undang-Undang RI Nomor 29 Tahun 2004 tentang Praktik Kedokteran, Undang-Undang RI Nomor 36 Tahun 2014 tentang Tenaga Kesehatan, Undang-Undang RI Nomor 8 Tahun 1999 tentang Perlindungan Konsumen, dan Kitab Undang-Undang Hukum Pidana. Di dalam peraturan perundang-undangan tersebut terdapat peraturan yang melarang penggunaan identitas yang menimbulkan kesan sebagai dokter serta ancaman pidana bagi pelaku pemalsuan. Sedangkan dalam penegakan hukum kasus pemalsuan identitas dokter di Indonesia dirasakan belum sesuai menurut perspektif keadilan. Kesimpulan penelitian bahwa penegakan hukum terhadap pemalsu identitas dokter telah dilakukan berdasarkan perundang-undangan yang terkait. Akan tetapi penerapan sanksi yang belum sepenuhnya didasarkan pada peraturan perundangan-undangan yang berlaku serta tidak mengandung prinsip-prinsip keadilan Kata kunci: Keadilan; Pemalsu Identitas; Penegakan Hukum.
Pengawasan dalam Badan Pengawasan Keuangan dan Pembangunan (BPKP) terhadap Keuangan Negara Berdasarkan Peraturan BPKP
Authors: Felencia Naomi Catherine 
Published: June 2023

The research aims to analyse the form of supervision carried out by the Financial and Development Supervisory Board (FDSB) on state financial reports based on FDSB regulations. The method used in this research is a normative method accompanied by an approach method through legislation. Results from this study are expected to provide knowledge regarding the role of FDSB in conducting supervision, especially in a case of corruption and the Social Insurance Administration Organization (BPJS) health body. In this case, the FDSB carries out its duties in accordance with laws and regulations. The FDSB has a duty to be a government oversight unit that is directly responsible to the President, does audits, and can also cooperate with other institutions. Keywords: Financial and Development Supervisory Board (FDSB), Supervision, Corruption, Social Insurance Administration Organization (BPJS). AbstrakPenelitian ini mempunyai tujuan untuk menganalisis bentuk pengawasan yang dilakukan oleh Badan Pengawasan Keuangan dan Pembangunan (BPKP) terhadap Keuangan Negara yang berdasarkan oleh peraturan BPKP. Metode yang digunakan dalam penelitian adalah metode normative yang disertai dengan metode pendekatan melalui peraturan perundang – undangan. Hasil penelitian ini diharapkan dapat memberi pengetahuan mengenai peran BPKP dalam melakukan pengawasan terutama dalam kasus Korupsi dan BPJS Kesehatan. Dalam kasus ini, BPKP menjalankan tugasnya sesuai dengan peraturan perundang-undangan. Dengan adanya penelitian ini, BPKP mempunyai tugas sebagai unit pengawasan pemerintah yang bertanggungjawab langsung kepada Presiden dan mempunyai tugas salah satunya melakukan audit yang selain itu juga dapat bekerja sama dengan lembaga lainnya.