bluuebunny/crossref_metadata_2025_split huggingface dataset:
MICROBEAUTY: ASSOCIAÇÃO ENTRE A MICROBIOTA DA PELE E O USO DE COSMÉTICOS
Authors: Póvoa Camila Santos , Coelho Caxito Samyra Mara , Brandão Fabiana 
Published: July 2023

A microbiota da pele humana desempenha um papel fundamental no equilíbrio e manutenção da saúde da pele. Estudos farmacêuticos recentes têm se concentrado nesse tópico. Embora a relação entre microbiota e cosméticos ainda seja recente, os dados disponíveis sugerem que os compostos nos cosméticos podem interferir no microecossistema da pele. Assim, este estudo teve como objetivo investigar os possíveis impactos do uso de cosméticos na microbiota da pele. Esta pesquisa foi uma revisão integrativa baseada no modelo PRISMA, que analisou e compilou dados em um fluxograma de acordo com critérios especificados. A coleta de artigos foi realizada no segundo semestre de 2022, de outubro a dezembro. A análise dos artigos incluídos revelou que os cosméticos podem ter um efeito negativo na microbiota da pele, uma vez que muitos ingredientes podem estender seus efeitos por dias, perturbando o microecossistema e alterando a diversidade molecular e bacteriana, muitas vezes causando disbiose. Portanto, o desafio da indústria de cosméticos está em torno do desenvolvimento ou seleção de ingredientes funcionais e ativos para criar produtos inócuos para a microbiota comensal.
MEDICAMENTOS PSICOTRÓPICOS E COVID-19: MANEJO TERAPÊUTICO
Authors: Cordova Victor Hugo Schaly , Belmonte-de-Abreu Paulo Silva 
Published: July 2023

No mês de março de 2020, a Organização Mundial da Saúde (OMS) declarou estado de pandemia, em decorrência do vírus SARS-CoV-2/COVID-19. No início de 2021 foram registrados 83.715.617 casos confirmados e 1.835.901 mortes por COVID-19. Desse modo, mundialmente há um esforço no sentido de desenvolver protocolos eficazes para o tratamento dessa doença. Uma das dificuldades encontradas é devida à heterogeneidade com o qual a COVID-19 afeta diferentes pacientes, devido a comorbidades. A não existência de medicamentos específicos no tratamento da COVID-19 é preocupante. Esse quadro se torna ainda mais grave quando consideramos possíveis interações entre esses medicamentos e os já utilizados previamente pelos pacientes, principalmente os de uso crônico. Nesse contexto, se enquadram os pacientes que possuam transtornos psiquiátricos, como transtorno depressivo maior, transtorno afetivo bipolar e esquizofrenia. Essa revisão teve como objetivo comparar diferentes protocolos farmacoterapêuticos no tratamento da COVID-19 em diferentes estágios quanto à sua segurança e eficácia em pacientes em tratamento para depressão, transtorno bipolar e esquizofrenia. Foi feita uma revisão em uma base de dados acerca de medicamentos mais citados para COVID-19 e pesquisadas possíveis interações entre os cinco mais citados no tratamento da COVID-19 e protocolos no tratamento de esquizofrenia, transtorno depressivo maior e transtorno afetivo bipolar. Foram excluídos ensaios não-clínicos, artigos que não apresentassem resultados (trials), artigos que apresentaram posterior retratação, artigos com idiomas estranhos aos autores e artigos relacionados a vacinas e terapias imunológicas que estão fora do escopo desse trabalho. Após as exclusões, foram considerados 117 estudos. Os medicamentos mais citados foram Hidroxicloroquina/Cloroquina (26 artigos), seguido por tocilizumab (10 artigos), ivermectina e rendesivir (oito artigos cada) e flavipinavir (sete artigos) A hidroxicloroquina e a cloroquina apresentaram vários resultados conflitantes e foram os medicamentos mais associados com interações medicamentosas em todas as classes de medicamentos estudadas.
Enhanced recovery after spine surgery: state of the art in the Russian Federation
Authors: Saifullin A. P. , Bokov A. E. , Aleinik A. Ya. , Mlyavykh S. G. 
Published: July 2023

Objective. To analyze the attitude of neurosurgeons to the technology of enhanced recovery after spine and spinal cord surgery in the Russian Federation.Material and Methods. In March 2022, a continuous cohort comparative sociological study was conducted among 83 neurosurgeons of the Russian Federation, during which they were asked to fill out a specially designed online questionnaire consisting of 22 questions on the Google Forms platform.Results. The vast majority of respondents (95.2 %) noted the lack of information in the Russian literature on the technology of enhanced recovery after surgery (ERAS). Nevertheless, most neurosurgeons, regardless of specialization, are familiar with the terms “fast track” (79.5 %) and “ERAS” (60.2 %). Only 44.6 % of specialists declared the implementation of ERAS recommendations into their daily clinical practice, while 78.3 % of neurosurgeons draw attention to the existence of problems that hamper adoption of enhanced recovery protocols (ERP) in Russia. The interviewed respondents are confident that it is possible to introduce ERP into spinal neurosurgery in adults (91.6 %) and children (85.5 %) in Russia. Every second respondent (50.6 %) considers it possible to directly extrapolate foreign ERP into clinical practice in Russian healthcare. Spinal neurosurgeons are more aware of ERAS than cerebral neurosurgeons (p = 0.017), and they also more often use elements of ERAS in their clinical practice (p = 0.002). In other parameters, the respondents did not differ significantly depending on their specialization. Only 7.2 % of interviewed neurosurgeons work in private clinics. All of them are engaged in spinal surgery and introduce the ERAS technology into their clinical practice. Less than half (40.0 %) of neurosurgeons in public clinics implement elements of the ERAS (p = 0.007). More than half (69.7 %) of specialists and every second manager consider the introduction of ERAS in a neurosurgical clinic to be progressive, and only a few of them (3.6 %), on the contrary, believe that the quality of medical care may decrease with the introduction of ERAS. Neurosurgeons (n = 13) identified 7 clinics of the Russian Federation, where the enhanced recovery protocol after spine surgery is implemented. In total, according to the results of the study, 23 elements of the ERAS protocol are implemented in the practice of respondents (n = 20) in the conditions of Russian healthcare.Conclusions. Despite the lack of publications in the Russian literature and the existing organizational problems in the context of domestic healthcare, neurosurgeons have a positive attitude towards the introduction of ERAS protocol into clinical practice. This protocol or its individual elements are already successfully implemented in a group of clinics in Russia.
Effect of curcumin on inflammatory biomarkers and iron profile in patients with premenstrual syndrome and dysmenorrhea: A randomized controlled trial
Authors: Talebpour Amir , Mohammadifard Mahtab , Zare Feyzabadi Reza , Mahmoudzadeh Sara , Rezapour Hadis , Saharkhiz Mansoore , Tajik Mahboube , Ferns Gordon A. , Bahrami Afsane 
Published: July 2023

AbstractPremenstrual syndrome (PMS) and primary dysmenorrhea are common gynecological problems and inflammation may have a role in their etiology. Curcumin is a polyphenolic natural product for which there is increasing evidence of anti‐inflammatory and iron chelation effects. This study assessed the effects of curcumin on inflammatory biomarkers and iron profile in young women with PMS and dysmenorrhea. A sample of 76 patients was included in this triple‐blind, placebo‐controlled clinical trial. Participants were randomly allocated to curcumin (n = 38) and control groups (n = 38). Each participant received one capsule (500 mg of curcuminoid+ piperine, or placebo) daily, from 7 days before until 3 days after menstruation for three consecutive menstrual cycles. Serum iron, ferritin, total iron‐binding capacity (TIBC) and high‐sensitivity C‐reactive protein (hsCRP), as well as white blood cell, lymphocyte, neutrophil, platelet counts, mean platelet volume (MPV) and red blood cell distribution width (RDW), were quantified. Neutrophil: lymphocyte ratio (NLR), platelet: lymphocyte ratio (PLR), and RDW: platelet ratio (RPR) were also calculated. Curcumin significantly decreased the median (interquartile range) serum levels of hsCRP [from 0.30 mg/L (0.0–1.10) to 0.20 mg/L (0.0–1.3); p = 0.041] compared with placebo, but did not show any difference for neutrophil, RDW, MPV, NLR, PLR and RPR values (p > 0.05). The treatment schedule was well‐tolerated, and none of markers of iron metabolism statistically changed after the intervention in the curcumin group (p > 0.05). Curcumin supplementation may have positive effects on serum hsCRP, a marker of inflammation, with no any changes on iron homeostasis in healthy women with PMS and dysmenorrhea.
The Effects of Palm Cooling on Physiological and Metabolic Responses, Exercise Performance, and Total Volume During High-Intensity Bench Press Exercise in Resistance-Trained Men
Authors: McMahon Gerard , Kennedy Rodney 
Published: July 2023

AbstractMcMahon, G, and Kennedy, R. The effects of palm cooling on physiological and metabolic responses, exercise performance, and total volume during high-intensity bench press exercise in resistance-trained men.J Strength Cond ResXX(X): 000–000, 2023—Previous research suggests that cooling distal to the working agonist muscles during the interset rest periods of high-intensity resistance exercise may facilitate improved performance by means of improving metabolic conditions of contractile machinery. However, these studies have not directly measured indicators of metabolic conditions. Therefore, the aim of this study was to compare 2 palm-cooling conditions with a thermoneutral condition during high-intensity resistance exercise and subsequent effects on physiological and metabolic responses and exercise performance. Eleven healthy, resistance-trained, young men (20–36 years old) performed 4 sets of bench press exercise to exhaustion at 80% 1 repetition maximum each separated by 3 minutes of passive recovery. Palm cooling (10° C [TEN] or 15° C [FTN]) or thermoneutral (28° C [CON]) condition was applied for 60 seconds during the recovery interval of each set in a randomized, double-blind fashion, with 4 days recovery between the experimental conditions. There were no differences (p> 0.05) in volume load between the experimental conditions across all sets. Mean repetition velocity and force of the bench press declined significantly following set 1 in all conditions (p< 0.05), but there were no differences between the conditions. Lactate, heart rate, and rating of perceived exertion systematically increased from sets 1 to 4; however, there were no significant differences (p> 0.05) between any of the conditions. Palm cooling at either 10 or 15° C had no observable effects on physiological and metabolic responses during exercise, nor has it any effect on bench press performance or volume load compared with a thermoneutral condition. Therefore, cooling cannot be currently recommended as an ergogenic strategy to enhance acute bench press performance or mitigate fatigue during high-intensity resistance training.
Postnatal Maturation of Membrane Potential Dynamics duringin VivoHippocampal Ripples
Authors: Noguchi Asako , Matsumoto Nobuyoshi , Ikegaya Yuji 
Published: July 2023

Sharp-wave ripples (SWRs) are transient high-frequency oscillations of local field potentials (LFPs) in the hippocampus and play a critical role in memory consolidation. During SWRs, CA1 pyramidal cells exhibit rapid spike sequences that often replay the sequential activity that occurred during behavior. This temporally organized firing activity gradually emerges during 2 weeks after the eye opening; however, it remains unclear how the organized spikes during SWRs mature at the intracellular membrane potential (Vm) level. Here, we recordedVm of CA1 pyramidal cells simultaneously with hippocampal LFPs from anesthetized immature mice of either sex after the developmental emergence of SWRs. On postnatal days 16 and 17,Vm dynamics around SWRs were premature, characterized by prolonged depolarizations without either pre- or post-SWR hyperpolarizations. The biphasic hyperpolarizations, features typical of adult SWR-relevantVm, formed by approximately postnatal day 30. ThisVm maturation was associated with an increase in SWR-associated inhibitory inputs to pyramidal cells. Thus, the development of SWR-relevant inhibition restricts the temporal windows for spikes of pyramidal cells and allows CA1 pyramidal cells to organize their spike sequences during SWRs.SIGNIFICANCE STATEMENTSharp-wave ripples (SWRs) are prominent hippocampal oscillations and play a critical role in memory consolidation. During SWRs, hippocampal neurons synchronously emit spikes with organized temporal patterns. This temporal structure of spikes during SWRs develops during the third and fourth postnatal weeks, but the underlying mechanisms are not well understood. Here, we recordedin vivomembrane potentials from hippocampal neurons in premature mice and suggest that the maturation of SWR-associated inhibition enables hippocampal neurons to produce precisely controlled spike times during SWRs.
Family Cohesion Moderates the Relation between Parent–Child Neural Connectivity Pattern Similarity and Youth's Emotional Adjustment
Authors: Zhou Zexi , Chen Ya-Yun , Yang Beiming , Qu Yang , Lee Tae-Ho 
Published: July 2023

Despite a recent surge in research examining parent–child neural similarity using fMRI, there remains a need for further investigation into how such similarity may play a role in children's emotional adjustment. Moreover, no prior studies explored the potential contextual factors that may moderate the link between parent–child neural similarity and children's developmental outcomes. In this study, 32 parent–youth dyads (parents:Mage= 43.53 years, 72% female; children:Mage= 11.69 years, 41% female) watched an emotion-evoking animated film while being scanned using fMRI. We first quantified how similarly emotion network interacts with other brain regions in responding to the emotion-evoking film between parents and their children. We then examined how such parent–child neural similarity is associated with children's emotional adjustment, with attention to the moderating role of family cohesion. Results revealed that higher parent–child similarity in functional connectivity pattern during movie viewing was associated with better emotional adjustment, including less negative affect, lower anxiety, and greater ego resilience in youth. Moreover, such associations were significant only among families with higher cohesion, but not among families with lower cohesion. The findings advance our understanding of the neural mechanisms underlying how children thrive by being in sync and attuned with their parents, and provide novel empirical evidence that the effects of parent–child concordance at the neural level on children's development are contextually dependent.SIGNIFICANCE STATEMENTWhat neural processes underlie the attunement between children and their parents that helps children thrive? Using a naturalistic movie-watching fMRI paradigm, we find that greater parent–child similarity in how emotion network interacts with other brain regions during movie viewing is associated with youth's better emotional adjustment including less negative affect, lower anxiety, and greater ego resilience. Interestingly, these associations are only significant among families with higher cohesion, but not among those with lower cohesion. Our findings provide novel evidence that parent–child shared neural processes to emotional situations can confer benefits to children, and underscore the importance of considering specific family contexts in which parent–child neural similarity may be beneficial or detrimental to children's development, highlighting a crucial direction for future research.
Propagation of Oscillations in the Indirect Pathway of the Basal Ganglia
Authors: Wilson Charles J. , Jones James A. 
Published: July 2023

Oscillatory signals propagate in the basal ganglia from prototypic neurons in the external globus pallidus (GPe) to their target neurons in the substantia nigra pars reticulata (SNr), internal pallidal segment, and subthalamic nucleus. Neurons in the GPe fire spontaneously, so oscillatory input signals can be encoded as changes in timing of action potentials within an ongoing spike train. When GPe neurons were driven by an oscillatory current in male and female mice, these spike-timing changes produced spike-oscillation coherence over a range of frequencies extending at least to 100 Hz. Using the known kinetics of the GPe→SNr synapse, we calculated the postsynaptic currents that would be generated in SNr neurons from the recorded GPe spike trains. The ongoing synaptic barrage from spontaneous firing, frequency-dependent short-term depression, and stochastic fluctuations at the synapse embed the input oscillation into a noisy sequence of synaptic currents in the SNr. The oscillatory component of the resulting synaptic current must compete with the noisy spontaneous synaptic barrage for control of postsynaptic SNr neurons, which have their own frequency-dependent sensitivities. Despite this, SNr neurons subjected to synaptic conductance changes generated from recorded GPe neuron firing patterns also became coherent with oscillations over a broad range of frequencies. The presynaptic, synaptic, and postsynaptic frequency sensitivities were all dependent on the firing rates of presynaptic and postsynaptic neurons. Firing rate changes, often assumed to be the propagating signal in these circuits, do not encode most oscillation frequencies, but instead determine which signal frequencies propagate effectively and which are suppressed.SIGNIFICANCE STATEMENTOscillations are present in all the basal ganglia nuclei, include a range of frequencies, and change over the course of learning and behavior. Exaggerated oscillations are a hallmark of basal ganglia pathologies, and each has a specific frequency range. Because of its position as a hub in the basal ganglia circuitry, the globus pallidus is a candidate origin for oscillations propagating between nuclei. We imposed low-amplitude oscillations on individual globus pallidus neurons at specific frequencies and measured the coherence between the oscillation and firing as a function of frequency. We then used these responses to measure the effectiveness of oscillatory propagation to other basal ganglia nuclei. Propagation was effective for oscillation frequencies as high as 100 Hz.
Environmental, mechanistic and evolutionary landscape of antibiotic persistence
Authors: Bollen Celien , Louwagie Elen , Verstraeten Natalie , Michiels Jan , Ruelens Philip 
Published: July 2023

AbstractRecalcitrant infections pose a serious challenge by prolonging antibiotic therapies and contributing to the spread of antibiotic resistance, thereby threatening the successful treatment of bacterial infections. One potential contributing factor in persistent infections is antibiotic persistence, which involves the survival of transiently tolerant subpopulations of bacteria. This review summarizes the current understanding of antibiotic persistence, including its clinical significance and the environmental and evolutionary factors at play. Additionally, we discuss the emerging concept of persister regrowth and potential strategies to combat persister cells. Recent advances highlight the multifaceted nature of persistence, which is controlled by deterministic and stochastic elements and shaped by genetic and environmental factors. To translate in vitro findings to in vivo settings, it is crucial to include the heterogeneity and complexity of bacterial populations in natural environments. As researchers continue to gain a more holistic understanding of this phenomenon and develop effective treatments for persistent bacterial infections, the study of antibiotic persistence is likely to become increasingly complex.
The Effect of Role Conflicts on Turnover Intention Auditors of Public Accounting Firms in The Covid-19 Pandemic
Authors: Lucyanda Jurica , Pratiwi Monica Weni , Hady Shofiyah 
Published: July 2023

AbstractPurpose: This study aims to examine the model of antecedents and consequences of role conflict of auditors working in Big 4 public accounting firms (KAP) in the era of the Covid-19 pandemic. The role conflicts used in the study were work-family conflict (WFC) and family-work conflict (FWC). The antecedent variable of the WFC and FWC used in the study is supervisor support. While the consequence variables of WFC and FWC are job stress, job satisfaction, job performance, and turnover intention. This study used conflict theory and conservation of resource theory to construct the hypotheses.Method: This research method is a survey method using electronic questionnaires. Respondents of this study are auditors working in KAP Big 4.Results: The results concluded that supervisor support was negatively significant to family-work conflict but not significant to work-family conflict. The results concluded that role conflicts impact job stress, job satisfaction, performance, and turnover intention.Novelty: This article contributes to research in behavioral accounting, primarily related to the topic of job stress due to role conflicts felt by auditors because having to work from home during the Covid-19 pandemic finally impacts turnover intentions.
Increased incidence of thyroid disease in patients with sarcoidosis: a systematic review and meta-analysis
Authors: Xin Caihong , Niu Lijuan , Fan Huaying , Xie Jing , Sun Xin 
Published: July 2023

Background
Sarcoidosis is a multiple systemic granulomatous disease, and its main pathological feature is non-caseous necrotic epithelial granuloma. The pathogenesis is not fully understood. The prevalence of thyroid disease is likely higher among individuals with sarcoidosis. However, this association still lacks clinical evidence.

Objective
The aim of this study was to estimate the incidence of thyroid disease in patients with sarcoidosis.

Methods
A literature search was conducted using PubMed, Web of Science, Embase, and China National Knowledge Infrastructure literature databases. Fixed- or random-effects models were used for analysis according to heterogeneity. The results were subjected to meta-analysis with odds ratios (ORs) and corresponding 95% confidence intervals (CIs).

Results
In total, six articles were included in this meta-analysis, which involved 2044 sarcoidosis cases and 5652 controls. The studies found that the incidence of thyroid disease in patients with sarcoidosis was significantly increased compared to the controls (OR 3.28, 95% CI 1.83–5.88).

Conclusions
This systematic review is the first to evaluate the incidence of thyroid disease in sarcoidosis patients, which was increased compared with the controls, suggesting that sarcoidosis patients should be screened for thyroid disease.