bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and Optimization of Aloe-Vera Static Shearing by Response Surface Methodology and Artificial Neural Network Methods
Authors: Rabbani Hekmat , Sohrabi Negin , Gholami Rashid 
Published: April 2023

Abstract
Knowledge of plants' mechanical properties and behavior is one of the essential factors in the design of harvesting and post-harvesting devices. In this study, horticulture, medicinal, and food plants of Aloe Vera were cut using a flat blade. Aloe Vera leaves are cut from the cross-section, and the force and energy required for cutting them were measured using Zwick /roll universal testing machine. The effect of cutting angle (0, 30, and 45 degrees), cutting speed (150, 250, 350, and 450 mm/min), and thickness of Aloe Vera leaves (1, 2, and 3 cm) on the force and energy required for cutting were investigated. To achieve this, response surface methodology was used, the results of which were compared with the artificial neural network method. The results of this study indicated that by increasing the cutting angle, cutting rate, and thickness of the leaves of the Aloe Vera plant, the energy required for its cutting decreased. The most optimal case for cutting the Aloe Vera plant in the case of cutting angle is 45 degrees, the cutting speed is 450 mm/min, and the thickness of Aloe Vera leaves is 3 cm, in which the required energy for cutting and cutting force is equal to 3.45 J and 4.99 N respectively. This study showed that Response Surface Methodology (RSM) is suitable for evaluating optimum conditions in Aloe Vera cutting experiments and is more accurate than the Artificial Neural Network (ANN) method.
Methodology to find malware super-spreader on the web infrastructure
Authors: Kim Sungjin 
Published: April 2023

Abstract
The Internet is an open platform and provides a diffusion network, thus enabling easy malware dissemination. Prior studies have focused on how social networking sites such as Facebook or Twitter are harnessed for diffusing malware extensively. They have also analyzed various inter-correlations between follower-followee in malware delivery behaviors. However, the findings cannot sufficiently explain malware distribution networks. The aim of this study is to find high-degree nodes that perform core roles in spreading malware on malware distribution networks. To do so, I first built a system to gather malicious URLs that participated in malware distribution. Second, I comprehensively learned the properties of malicious URLs. For instance, attackers construct the geolocation between landing sites that users first access and exploit sites that launch attacks in a different manner. Different geographic locations make it difficult for defenders to detect and block core malicious URLs. Hence, defenders need to search for other malicious URLs at possible control locations. Third, all websites involved in malware distribution were reconstructed into a network with nodes. Each node was assigned a risk. For instance, the contamination rate of malware that propagates through Google with many users definitely differs from that of websites with few users. Based on this approach, a method for measuring the overall risk of malware distribution networks was proposed. This model helps in finding significant nodes that largely influence malware diffusion.
Computational model and simulations of contact angle and geometry effects on centrifugal microfluidic step-emulsification
Authors: Fahland Maximilian , Mishra Rohit 
Published: April 2023

Abstract
The generation of droplets in microfluidic systems is extensively applied in various chemical and biological applications. For two-phase immiscible micro-droplet formation, both actively and passively driven systems being employed. Active systems typically include pump-based, magnetic actuation or centrifugal flow control-based methods that employ cross-flowing, flow-focusing or co-flowing microfluidic architecture to assist formation. Numerical modelling using computational fluid dynamics (CFD) allows for an in-silico approach in the understanding of the micro-droplet formation behaviour and the effect of several parameters on the size and rate of droplet formation. Although several such models have been presented previously for pump driven cross-flowing, flow focusing or co-flowing microfluidic architectures, systems typically employing centrifugal actuation methods are limited. We investigate here a CFD method for modelling and simulating step-emulsification of water-in-oil, on a centrifugal microfluidics platform. The effects of contact angles, supply channel geometry and capillary number were studied using the numerical model and compared to experimental data from previous work.
Long run non-linearity in CO2 Emissions: The I(2) Cointegration Model and the Environmental Kuznets Curve
Authors: Kivedal Bjørnar Karlsen 
Published: April 2023

Abstract
I use the I(2) cointegration model in order to assess the empirical relevance of the environmental Kuznets curve for CO2 emissions in the US between 1960 and 2014. This takes the non-linearity of CO2 emissions into account by allowing for using data that are integrated of order two, I(2), directly in the model. This provides an extensive dynamic analysis of the relationship between emissions and economic growth as postulated by the environmental Kuznets curve both in the short, medium and long run. The results indicate that the main driver behind the non-linear shape of US CO2 emissions in the long run is an increase in emissions caused by energy use and a decrease caused by more trade and using less polluting energy sources. GDP only have short run effects. Hence, I do not find evidence in favor of a long run relationship between economic development and the concave shape of emissions as suggested by the environmental Kuznets curve.
JEL classification: C32; Q43; Q56
Cantharidin and sodium fluoride attenuate the negative inotropic effects of carbachol in the isolated human atrium
Authors: Schwarz Rebecca , Hofmann Britt , Gergs Ulrich , Neumann Joachim 
Published: April 2023

Abstract
Introduction: Carbachol, an agonist at muscarinic receptors, exerts negative inotropic effects in human atrium. Carbachol can activate protein phosphatases (PP1 or PP2A). We hypothesized that cantharidin or sodium fluoride, inhibitors of PP1 and PP2A, might attenuate negative inotropic effects of carbachol.
Methods: During bypass-surgery trabeculae carneae human atrial preparations (HAP) were obtained. These trabeculae were mounted in organ baths and electrically stimulated (1 Hz). Force of contraction was measured under isometric conditions. For comparison, we studied isolated electrically stimulated left atrial preparations (LA) from mice.
Results: 100 µM cantharidin and 3 mM sodium fluoride increased force of contraction in LA (n = 5-8, p < 0.05) by 113 % ± 24.5 % and by 100 % ± 38.2 % and in HAP (n = 13-15, p < 0.05 ) by 625 % ± 169 % and by 196 % ± 23.5 %, respectively. Carbachol 1 µM alone exerted a rapid transient maximum negative inotropic in LA (n = 6) and HAP (n = 14) to 46.9 % ± 3.63 % and 19.4 % ± 3.74 %, respectively (p < 0.05). These negative inotropic effects were smaller in LA (n = 4-6) and HAP (n = 9-12) pretreated with 100 µM cantharidin and amounted to 58.0 % ± 2.27 % and 59.2 % ± 6.19 % or 3 mM sodium fluoride to 63.7 % ± 9.84 % and 46.3 % ± 5.69 %, (p<0.05).
Conclusion: We suggest that carbachol, in part, exerts a negative inotropic effect in the human atrium by putatively stimulating the enzymatic activity of PP1 and/or PP2A.
Cannabidiol in the dorsal hippocampus attenuates emotional and cognitive impairments related to neuropathic pain: role of prelimbic neocortex-hippocampal connections
Authors: Medeiros Ana Carolina , Medeiros Priscila , Pigatto Glauce Regina , Coimbra Norberto Cysne , de Freitas Renato Leonardo 
Published: April 2023

Abstract

Background and Purpose

Chronic neuropathic pain (NP) is commonly associated with cognitive and emotional impairments. Cannabidiol (CBD) presents a broad spectrum of action with a potential analgesic effect. This work investigates the CBD effect on comorbidity between chronic NP, depression, and memory impairment.

Experimental Approach

The connection between the neocortex and the hippocampus was investigated with biotinylated dextran amine (BDA) deposits in the prelimbic cortex (PrL). Wistar rats were submitted to chronic constriction injury (CCI) of the sciatic nerve and CA1-treatment with CBD (15, 30, 60 nmol).

Key Results

BDA-labeled were found in CA1 and dentate gyrus. CCI-induced mechanical and cold allodynia increased c-Fos protein expression in the PrL and CA1. The number of astrocytes in PrL and CA1 increased, and the number of neuroblasts decreased in CA1. The CCI animals showed increasing depressive-like behaviors, such as memory impairment. CBD (60 nmol) treatment decreased mechanical and cold allodynia, attenuated depressive-associated behaviors, and improved memory performance. Cobalt chloride (CoCl2: 1 nM), WAY-100635 (0.37 nmol), and AM251 (100 nmol) intra-PrL reversed the CBD (60 nmol) effect intra-CA1, both in nociceptive, cognitive, and depressive behaviors.

Conclusion

CBD represents a promising therapeutic perspective in the pharmacological treatment of chronic NP and associated comorbidities such as depression and memory impairments. The CBD effects possibly recruit the CA1-PrL pathway, inducing neuroplasticity. CBD acute treatment into the PrL cortex produces functional, molecular, and morphological improvements.
Biology of Tenascin C and its Role in Physiology and Pathology
Authors: Abedsaeidi Malihehsadat , Hojjati Farzaneh , Tavassoli Amin , Sahebkar Amirhossein 
Published: April 2023

Abstract:Tenascin-C (TNC) is a multimodular extracellular matrix (ECM) protein hexameric with several molecular forms (180-250 kDa) produced by alternative splicing at the pre-mRNA level and protein modifications. The molecular phylogeny indicates that the amino acid sequence of TNC is a well-conserved protein among vertebrates. TNC has binding partners, including fibronectin, collagen, fibrillin-2, periostin, proteoglycans, and pathogens. Various transcription factors and intracellular regulators tightly regulate TNC expression. TNC plays an essential role in cell proliferation and migration. Unlike embryonic tissues, TNC protein is distributed over a few tissues in adults. However, higher TNC expression is observed in inflammation, wound healing, cancer, and other pathological conditions. It is widely expressed in a variety of human malignancies and is recognized as a pivotal factor in cancer progression and metastasis. Moreover, TNC increases both pro-and anti-inflammatory signaling pathways. It has been identified as an essential factor in tissue injuries such as damaged skeletal muscle, heart disease, and kidney fibrosis. This multimodular hexameric glycoprotein modulates both innate and adaptive immune responses regulating the expression of numerous cytokines. Moreover, TNC is an important regulatory molecule that affects the onset and progression of neuronal disorders through many signaling pathways. We provide a comprehensive overview of the structural and expression properties of TNC and its potential functions in physiological and pathological conditions.
MiR-142-3p is a Critical Modulator of TNF-mediated Neuronal Toxicity in
Multiple Sclerosis
Authors: De Vito Francesca , Balletta Sara , Caioli Silvia , Musella Alessandra , Guadalupi Livia , Vanni Valentina , Fresegna Diego , Bassi Mario Stampanoni , Gilio Luana , Sanna Krizia , Gentile Antonietta , Bruno Antonio , Dolcetti Ettore , Buttari Fabio , Pavone Luigi , Furlan Roberto , Finardi Annamaria , Perlas Emerald , Hornstein Eran , Centonze Diego , Mandolesi Georgia 
Published: April 2023

Background:
TNF-dependent synaptotoxicity contributes to the neuronal damage occurring
in patients with Multiple Sclerosis (pwMS) and its mouse model Experimental Autoimmune Encephalomyelitis
(EAE). Here, we investigated miR-142-3p, a synaptotoxic microRNA induced by inflammation
in EAE and MS, as a potential downstream effector of TNF signalling.

Methods:
Electrophysiological recordings, supported by molecular, biochemical and histochemical
analyses, were performed to explore TNF-synaptotoxicity in the striatum of EAE and healthy mice.
MiR-142 heterozygous (miR-142 HE) mice and/or LNA-anti miR-142-3p strategy were used to verify
the TNF-miR-142-3p axis hypothesis. The cerebrospinal fluid (CSF) of 151 pwMS was analysed to
evaluate possible correlation between TNF and miR-142-3p levels and their impact on clinical parameters
(e.g. progression index (PI), age-related clinical severity (gARMSS)) and MRI measurements
at diagnosis (T0).

Results:
High levels of TNF and miR-142-3p were detected in both EAE striatum and MS-CSF. The
TNF-dependent glutamatergic alterations were prevented in the inflamed striatum of EAE miR-142
HE mice. Accordingly, TNF was ineffective in healthy striatal slices incubated with LNA-anti miR-
142-3p. However, both preclinical and clinical data did not validate the TNF-miR-142-3p axis hypothesis,
suggesting a permissive neuronal role of miR-142-3p on TNF-signalling. Clinical data showed a
negative impact of each molecule on disease course and/or brain lesions and unveiled that their high
levels exert a detrimental synergistic effect on disease activity, PI and white matter lesion volume.

Conclusion:
We propose miR-142-3p as a critical modulator of TNF-mediated neuronal toxicity and
suggest a detrimental synergistic action of these molecules on MS pathology.
Analisis Jaringan Opini Publik tentang Pembatasan Sosial Berskala Besar di Twitter
Authors: Setiadi Tatak 
Published: April 2023

AbstrakPemerintah Indonesia memutuskan untuk meluncurkan kebijakan Pembatasan Sosial Berskala Besar (PSBB) setelah mendapati kejadian CoVID-19 di Jakarta. Keputusan itu menjadi trending topic di media sosial Twitter. Penelitian ini bertujuan untuk mengidentifikasi aktor utama dan pergerakan opini mengenai isu PSBB di Twitter di Indonesia. Penelitian ini menggunakan RStudio untuk mendapatkan sekitar 5.000 tweet pada 6 Mei 2020 dengan kata kunci "psbb" dan tagar #psbb. Hasil text mining, analisis sosiogram, dan Social Network Analysis (SNA) mendapatkan temuan menarik. Pertama, opini tentang PSBB di Twitter sebagian besar berisi candaan tentang Pembatasan Sosial Berujung Bubaran. Candaan ini dipopulerkan oleh FiersaBesari. Kedua, muncul tujuh akun organisasi yang berperan sebagai penggiring opini publik. Ketiga, pengguna akun Twitter paling dominan adalah Yunartowijaya, Direktur Eksekutif Lembaga Polling Politik, Charta Politika Indonesia. Dan keempat, media berita online yang paling aktif memuat tentang PSBB adalah detikcom dan CNN Indonesia. Selain itu, analisis juga menemukan bahwa aktor yang berafiliasi dengan Fraksi Demokrat pada DPR RI secara aktif mengkritik kebijakan Pemerintah Indonesia tentang penetapan PSBB. Kata kunci: Analisis Jaringan Sosial, Media Sosial, Opini Publik, PSBB AbstractThe Government of Indonesia has decided to launch a Nationwide Social Distancing (PSBB) policy after acknowledging the CoVID-19 outbreaks in Jakarta. The decision became a trending topic on social media Twitter. This study aims to identify the main actors and opinion movements regarding the PSBB issue on Twitter in Indonesia. This study used RStudio to mine around 5,000 tweets on May 6, 2020 using the keyword "psbb" and the hashtag #psbb. The results of text mining, sociogram analysis, and Social Network Analysis (SNA) found interesting findings. First, opinions about PSBB on Twitter mostly about jokes on Social Distancing and Relationship Break. This joke was popularized by FiersaBesari. Second, there are seven organizational accounts that act as leading public opinion. Third, the most dominant Twitter account user is Yunartowijaya, Executive Director of the Political Polling Institute, Charta Politika Indonesia. And fourth, the online news media that most actively discussing about PSBB are detikcom and CNN Indonesia. In addition, the analysis also found that actors affiliated with the Democratic Faction in the DPR RI actively criticized The Gorvernment of Indonesia’s decission on PSBB policy. Keywords: PSBB, Public Opinion, Social Media, Social Network Analysis
Komunikasi Kepemimpinan dalam Perubahan Organisasi Pemerintah
Authors: Aprianto Yudie , Kumorotomo Wahyudi , Rajiyem Rajiyem 
Published: April 2023

An organization experiences changes on a constant basis. The institution is driven to adapt and survive in this competitive environment by both internal and external stimuli. To manage organisational change, leaders play a crucial role. However, more research is still needed in the field of how leaders react and communicate in the context of organizational change, particularly in the public institution. In explaining leadership communication in organizational change, existing studies frequently use widely accepted views such as leadership styles that frequently contradict one another. Therefore, this research aims to investigate how leadership communication is carried out in the context of organizational change. How a public organization prepares for and integrates into a new government organization is investigated using qualitative and interpretive methods with a case study method. The role of leadership communication in managing organizational change was examined from a sensemaking point of view. In order to gain a complete picture of leadership communication, 17 participants were interviewed at different organizational levels. By demonstrating how leaders navigate an organization's managerial change discourse by integrating their bracketed information from various relevant sources, choosing information, and reconstructing information through communication, this article makes a valuable contribution to the literature on leadership communication.
Free Verdict Against Executors of Illegal Fees as Corruption Crimes
Authors: Sani Agnesia Mutiara , Shafira Maya , Fardiansyah Ahmad Irzal 
Published: April 2023

Illegal levies are the designation of all forms of levies that are unofficial, which have no legal basis, so the act of levies is referred to as illegal levies. One of the criminal acts of corruption that occurs in people's lives is illegal fees. An example of a criminal case of illegal fees is the case in Decision Number: 46/Pid.Sus-TPK/2018/PN.Tjk in that case the defendant was acquitted. Judging from the judge's decision that acquitted the defendant, the authors conducted research on the identification of illegal fees as a criminal act of corruption and what was the basis for the considerations of the Panel of Judges in passing an acquittal in cases of criminal acts of corruption based on Decision Number: 46/Pid.Sus-TPK/2018/ PN. Tjk. The problem with this research is the identification of extortion as a criminal act of corruption. and what are the basic considerations of the Panel of Judges in passing an acquittal in a corruption case based on Decision Number: 46/ Pid.Sus -TPK/2018/PN. Tjk
The research method used is normative juridical research method, sources of primary and secondary legal materials. From this study it can be concluded that illegal fees can be categorized as a criminal act of corruption, this action is regulated in Article 12 letter e of Law Number 31 of 1999 which has been amended and added to Law Number 20 of 2001 concerning Eradication of Corruption Crimes. That the basis for the judge's considerations in deciding that the corruption case was free of Decision Number: 46/Pid.Sus-TPK/2018/PN.Tjk Defendant did not meet the elements of "benefiting oneself or others" and the element of "receiving gifts or promises" as charged in the Alternative indictment by the Public Prosecutor, so that the defendant is not legally and convincingly proven guilty of committing a criminal act of corruption.
Oral Manifestation in Pregnant Women in Sulaimaniyah City
Authors: A Hama Amin, Sonya , Mohamed Ahmed Khadija 
Published: April 2023

Background: Pregnancy is a physiological process during which a major hormonal change take place which leads to an imbalance in the oral environment and development of oral manifestation that can adversely affect mother’s health and the health of the unborn child.
Objective: To assess the prevalence of the oral manifestation of pregnant women and to evaluate the correlation of these manifestations with the oral hygiene status.
Patients and Methods: A total of 150 pregnant women were enrolled in this study on which a meticulous intraoral examination and evaluation of oral health status using oral hygiene index simplified (OHI-S) carried out.
Results: The most involved age group was (21-25) years 38.00%. It was concluded that the most frequent oral finding was halitosis 67.33%, followed by dry mouth 59.33%, taste alteration 46%, pregnancy epulis 9.33%, candidiasis 7.33%, and ulceration 4%. In addition, pregnancy epulis and halitosis were significantly correlated with poor oral hygiene.
Conclusion: Pregnancy is associated with oral manifestations; therefore, dentists should be aware of such manifestations and provide education regarding oral health status and maintenance of good oral hygiene during pregnancy
REVISTA CIENTIFICA EM EDUCAÇÃO - CLEO ASSESSORIA E EDITORA EM EDUCAÇÃO - VOLUME 3/2023
Authors: EDUCAÇÃO CLEO ASSESSORIA E EDITORA EM 
Published: April 2023

REVISTA CIENTÍFICA EM EDUCAÇÃO
FACULDADE IGUAÇU – CLEO EDITORA
PERIÓDICO MENSAL

SUMÁRIO

1.	INCLUSÃO ESCOLAR DE CRIANÇAS AUTISTAS: POSSIBILIDADES E REFLEXÕES ......................................................................................................................... 5

2.	TIPOS DE JOGOS E BRINCADEIRAS QUE ESTIMULAM A APRENDIZAGEM .................................................................................................................................................. 10

3.	A INCLUSÃO DIGITAL NA EDUCAÇÃO INFANTIL - UM OLHAR PARA A REDE MUNICIPAL DE EDUCAÇÃO EM CUIABÁ –MT ......................................................... 14

4.	DIFICULDADES DE APRENDIZAGEM – TDAH ....................................................................... 22

5.	EDUCAÇÃO INCLUSIVA COMO UM PASSO IMPORTANTE PARA A CIDADANIA ....... 27
KONSEP ASAS PARTISIPASI DALAM PELAKSANAAN PEMBANGUNAN DESA SEBAGAI UPAYA PENCEGAHAN TINDAK PIDANA KORUPSI
Authors: Latif Abdul , Karmilia Rise 
Published: April 2023

Tujuan dari penelitian ini untuk mengetahui konsep asas partisipasi pelaksanaan pembangunan desa dalam perspektif Undang-Undang No. 6 tahun 2014 tentang Desa, sekaligus melihat peran asas partisipasi dalam mencegah tindak pidana korupsi pelaksanaan pembangunan desa. Tipe penelitian hukum adalah yuridis normatif dengan demikian tipologi penelitian yang dilakukan adalah preskriptif. Sumber data yang digunakan dalam penelitian ini merupakan sumber data sekunder, berupa bahan hukum primer, bahan hukum sekunder, bahan hukum tersier. Pengumpulan data dilakukan dengan teknik kepustakaan (library research) dengan meneliti sumber bacaan yang berhubungan dengan topik penelitian. Data yang diperoleh melalui studi pustaka (library research) dikumpulkan, diurutkan, dan diorganisasikan dalam satu pola, kategori dan satuan dasar, kemudian data tersebut dianalisis dengan metode kualitatif. Partisipasi masyarakat telah hadir ketika masih dalam tahap perencanaan desa dengan tujuan pencegahan secara dini terhadap potensi korupsi. Namun partisipasi masyarakat tidak akan dapat berjalan maksimal jika tanpa adanya transparansi dan akuntabilitas dari pemerintah desa. Partisipasi masyarakat sebagai sebuah kontrol sosial dalam rangka pencegahan tindak pidana korupsi dalam pembangunan desa dapat dilakukan dalam tahap perencanan melalui penilaian penyusunan RPJMDES dan RKP, sedangkan dalam tahap pelaksanaan, pengawasan berupa penilaian terhadap pengadaan barang dan/atau jasa, pengadaan barang material, pengadaan tenaga kerja, pengelolaan administrasi keuangan, pengiriman bahan material, dan kualitas hasil pembangunan desa.