bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organismal landscape of clock cells and circadian gene expression inDrosophila
Authors: Patop Ines L. , Anduaga Ane Martin , Bussi Ivana L. , Ceriani M. Fernanda , Kadener Sebastian 
Published: May 2023

ABSTRACTBackgroundCircadian rhythms time physiological and behavioral processes to 24-hour cycles. It is generally assumed that most cells contain self-sustained circadian clocks that drive circadian rhythms in gene expression that ultimately generating circadian rhythms in physiology. While those clocks supposedly act cell autonomously, current work suggests that inDrosophilasome of them can be adjusted by the brain circadian pacemaker through neuropeptides, like the Pigment Dispersing Factor (PDF). Despite these findings and the ample knowledge of the molecular clockwork, it is still unknown how circadian gene expression inDrosophilais achieved across the body.ResultsHere, we used single-cell and bulk RNAseq data to identify cells within the fly that express core-clock components. Surprisingly, we found that less than a third of the cell types in the fly express core-clock genes. Moreover, we identified Lamina wild field (Lawf) and Ponx-neuro positive (Poxn) neurons as putative new circadian neurons. In addition, we found several cell types that do not express core clock components but are highly enriched for cyclically expressed mRNAs. Strikingly, these cell types express the PDF receptor (Pdfr), suggesting that PDF drives rhythmic gene expression in many cell types in flies. Other cell types express both core circadian clock components andPdfr, suggesting that in these cells, PDF regulates the phase of rhythmic gene expression.ConclusionsTogether, our data suggest three different mechanisms generate cyclic daily gene expression in cells and tissues: canonical endogenous canonical molecular clock, PDF signaling-driven expression, or a combination of both.
Gene Expression Profiling and Physiological Adaptations of Pearl Spot (Etroplus suratensis) under Varying Salinity Conditions
Authors: Marbade Pranali Prabhakar , Shanmugam S. A. , Suresh E. , Rathipriya A. , Agarwal Deepak 
Published: May 2023

AbstractEutroplus suratensis(Pearl spot) is naturally found in estuarine environments and has been noted to have a high salinity tolerance, with the ability to thrive in freshwater as well as seawater. By examining the impact of various salinity levels on the growth and survival of Pearl spot, the present study aims to enhance aquaculture profitability by assessing their adaptability and physiological adjustments to changes in salinity, as well as determining their potential to acclimate to a broad range of salinity regimes. Pearl spot fingerlings were placed in tanks with varying salinities (15, 25, 35, 45, 60, and 75ppt) and monitored for mortality at 24-hour intervals up to 120 hours. Results revealed no mortality in the control group (0ppt), as well as in the 15, 25, and 35ppt treatment groups. However, the remaining groups (45, 60, and 75ppt) showed differing levels of mortality, with 44% mortality observed in the 45ppt group and 100% mortality in both the 60 and 75ppt groups. The impact of different salinity levels on the expression of pearl spot genes such as IGF-1, SOD, CAT, NaKATPase, OSTF-1, and HSP70 was investigated, along with a histological examination of the gills. The results showed significant physiological and cellular damage caused by the salinity levels. The expression analysis showed that liver IGF-1 mRNA expression increased by 2.6-fold at 15ppt, and HSP70 mRNA expression in the liver also showed a significant increase with rising salinity levels. In addition, OSTF1 expression exhibited an increase at 15ppt, whereas SOD and CAT expression reached their highest levels at 25ppt. At 15ppt, the expression of NKA mRNA increased significantly by 2.8-fold. The study’s overall findings suggested that the fish demonstrated strong molecular-level performance between 15 to 25ppt salinity levels, with the best results observed at 15ppt. These findings suggest that utilizing a salinity level of 15ppt for Pearl spot production could be viable for profitable aquaculture.
Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion
Authors: Sun Yi , Florio Tyler J. , Gupta Sagar , Young Michael C. , Marshall Quinlen F. , Garfinkle Samuel E. , Papadaki Georgia F. , Truong Hau V. , Mycek Emily , Li Peiyao , Farrel Alvin , Church Nicole L. , Jabar Shereen , Beasley Matthew D. , Kiefel Ben R. , Yarmarkovich Mark , Mallik Leena , Maris John M. , Sgourakis Nikolaos G. 
Published: May 2023

AbstractPeptide-Centric Chimeric Antigen Receptors (PC-CARs), which recognize oncoprotein epitopes displayed by human leukocyte antigens (HLAs) on the cell surface, offer a promising strategy for targeted cancer therapy1. We have previously developed a PC-CAR targeting a neuroblastoma- associated PHOX2B peptide, leading to robust tumor cell lysis restricted by two common HLA allotypes2. Here, we determine the 2.1 Å structure of the PC-CAR:PHOX2B/HLA-A*24:02/β2m complex, which reveals the basis for antigen-specific recognition through interactions with CAR complementarity-determining regions (CDRs). The PC-CAR adopts a diagonal docking mode, where interactions with both conserved and polymorphic HLA framework residues permit recognition of multiple HLA allotypes from the A9 serological cross-reactivity group, covering a combined American population frequency of up to 25.2%. Comprehensive characterization using biochemical binding assays, molecular dynamics simulations, and structural and functional analyses demonstrate that high-affinity PC-CAR recognition of cross-reactive pHLAs necessitates the presentation of a specific peptide backbone, where subtle structural adaptations of the peptide are critical for high-affinity complex formation and CAR-T cell killing. Our results provide a molecular blueprint for engineering CARs with optimal recognition of tumor-associated antigens in the context of different HLAs, while minimizing cross-reactivity with self-epitopes.
The genome ofSalmacisia buchloëana, the parasitic puppetmaster pulling strings of sexual phenotypic monstrosities in buffalograss
Authors: Benson Christopher W. , Sheltra Matthew R. , Huff David R. 
Published: May 2023

AbstractTo complete its parasitic lifecycle,Salmacisia buchloëana, a biotrophic fungus, manipulates reproductive organ development, meristem determinacy, and resource allocation in its dioecious plant host, buffalograss (Bouteloua dactyloides;Poaceae). To gain insight intoS. buchloëana’sability to manipulate its host, we sequenced and assembled the 20.1 Mb genome ofS. buchloëanainto 22 chromosome-level pseudomolecules. Phylogenetic analysis suggests thatS. buchloëanais nested within the genusTilletiaand diverged fromT. cariesandT. walkeri ∼40 million years ago. We find thatS. buchloëanahas a novel chromosome arm with no syntenic relationship to other publicly availableTilletiagenomes and that genes on the novel arm are upregulated upon infection, suggesting that this unique chromosomal segment may have played a critical role inS. buchloëana’sevolution and host specificity.Salmacisia buchloëanahas one of the largest fractions of serine peptidases (1.53% of the proteome) and one of the highest GC contents (62.3%) in all classified fungi. Analysis of codon base composition indicated that GC content is controlled more by selective constraints than directional mutation and thatS. buchloëanahas a unique bias for the serine codon UCG. Finally, we identify three inteins within theS. buchloëanagenome, two of which are located in a gene often used in fungal taxonomy. The genomic and transcriptomic resources generated here will aid plant pathologists and breeders by providing insight into the extracellular components contributing to sex determination in dioecious grasses.
Wage dispersion and sports performance: does gender matter?
Authors: Arutiunova Margarita , Gasparetto Thadeu 
Published: May 2023

Purpose
Previous studies focused predominantly on wage dispersion within men’ sports teams. This study aims to reveal how the relationship between wage dispersion and team performance applies for women’s sport.

Design/methodology/approach
The sample comprises 168 observations of four consecutive National Basketball Association (NBA) and Women’s National Basketball Association (WNBA) regular seasons (2018–2021). Eight econometric models are performed for comparing the leagues.

Findings
The findings indicate that the wage dispersion within the squads affects the women’s and men’s basketball teams differently. Cohesiveness theory is applicable for WNBA teams, while NBA teams follow the tournament theory.

Originality/value
To the best of the authors’ knowledge, this is the first paper which inspects the relationship between wage dispersion and team performance using data from women’s sports. Further research may examine whether the differences found in sports also apply in different labor markets.
Retailing during the COVID-19 lifecycle: a bibliometric study
Authors: Gupta Astha Sanjeev , Mukherjee Jaydeep , Garg Ruchi 
Published: May 2023

PurposeCOVID-19 disrupted the lives of consumers across the globe, and the retail sector has been one of the hardest hits. The impact of COVID-19 on consumers' retail choice behaviour and retailers' responses has been studied in detail through multiple lenses. Now that the effect of COVID-19 is abating, there is a need to consolidate the learnings during the lifecycle of COVID-19 and set the agenda for research post-COVID-19.Design/methodology/approachScopus database was searched to cull out academic papers published between March 2020 and June 6, 2022, using keywords; shopping behaviour, retailing, consumer behaviour, and retail channel choice along with COVID-19 (171 journals, 357 articles). Bibliometric analysis followed by selective content analysis was conducted.FindingsCOVID-19 was a black swan event that impacted consumers' psychology, leading to reversible and irreversible changes in retail consumer behaviour worldwide. Research on changes in consumer behaviour and consumption patterns has been mapped to the different stages of the COVID-19 lifecycle. Relevant research questions and potential theoretical lenses have been proposed for further studies.Originality/valueThis paper collates, classifies and organizes the extant research in retail from the onset of the COVID-19 pandemic. It identifies three retail consumption themes: short-term, long-term reversible and long-term irreversible changes. Research agenda related to the retailer and consumer behaviour is identified; for each of the three categories, facilitating the extraction of pertinent research questions for post-COVID-19 studies.
Commensuration of health-care quality standards through hospital accreditation: from measurement weapon to management tool?
Authors: Vega Miguel , Cunha Joao Vieira da 
Published: May 2023

Purpose
The purpose of this study is to examine the management perceptions towards calculative practices behind the reconstruction of a mandatory hospital accreditation (HA) system that transforms multiple facets of health-care quality into a single performance index.

Design/methodology/approach
This study contributes to the sociology of quantification mobilising the concept of commensuration as a social process to reflect on contemporary changes in managing HA systems. Data are collected adopting a case study of a Spanish public hospital drawing on semi-structured interviews, observation and documentary review.

Findings
Findings emphasise a shift from standards’ compliance to a more comprehensive view encouraging continuous quality improvement. Accreditation acts as a tin opener to facilitate external inspection removing contextual differences amongst hospitals and reducing organisational practices into controllable objects. It also reveals underlying ethical concerns as the system was built as a care quality measure that promptly developed into an attainment goal.

Practical implications
The valuable role of HA to enhance quality standards and the limitations resulting from its commensuration practices will be of interest to policymakers, organisational managers and researchers.

Originality/value
Despite a growing emphasis on audit and valuation practices in health care, accounting studies examining the capacity of public hospitals to manage quality improvement are scarce. This study inspires further research on accreditation to overcome commensuration flaws regarding external transparency, evaluation ambiguity and extra incentives.
How improved understanding of what constitutes “value” may lead to better underpinning of corporate social responsibility (CSR)
Authors: Richardson Neil , Cassop Thompson Michael 
Published: May 2023

Purpose
The aim of this conceptual paper, predicated on a hermeneutic literature review, is to improve understanding of the nature of value continues to be extensively studied with its ability to create competitive advantage. Understanding what constitutes value improves corporate social responsibility (CSR) comprehension, including managerial CSR values. This paper aligns with studies into value and/or CSR, whether hermeneutic or otherwise.

Design/methodology/approach
This study provides a reflexively critical understanding of the value literature. It focuses on the “identifying” stage of a hermeneutic circle (identifying central terms, core journals and seminal authors). A hermeneutic helix is proposed to better reflect the need of constant re-interpretation of the relevant literature.

Findings
Themes include value location (value in exchange, value in use, value in meaning and value in context); architecture (pathways, constellations and networks); creation versus determination; and value types.

Research limitations/implications
This paper neither seeks to define value nor delve into the overarching value discourses. It does, however, refer to the antecedents for these areas. As a hermeneutic literature review, it lacks empirical testing.

Practical implications
CSR practices are strongly influenced by personal values. Hence, CSR practitioners must identify the processes involved and differentiate between the sought value and value types.

Social implications
The paper could engender better understanding gaps between stakeholder attitudes and practices, i.e. consumers self-identifying as “green” may not engage in ecologically sound practices. As discussed herein, the value sought by university students influences where (and what) to study.

Originality/value
Outdated notions such as value propositions are widely used; value may be proposed; however, only stakeholders can take value. What constitutes value is under-represented in the CSR literature. Hence, terms such as value and values (i.e. value types) are incorrectly used interchangeably.
Knowledge sharing and theory of planned behavior: a bibliometric analysis
Authors: Fauzi Muhammad Ashraf , Nguyen Mai , Malik Ashish 
Published: May 2023

Purpose
The purpose of this study is to review the role of knowledge-sharing and its association with the Theory of Planned Behavior (TPB). TPB is the most used theory in understanding knowledge-sharing behavior in many contexts.

Design/methodology/approach
Based on the bibliometric approach, this study extracted and analyzed 229 journal articles on the Web of Science. In addition, two analyses (bibliographic coupling and co-word) were performed to provide science mapping in presenting the knowledge structure on the present and future research direction on knowledge-sharing and TPB.

Findings
The findings of this study suggest that two stand-out clusters are determinants and antecedents of knowledge-sharing behavior based on TPB and the role of the virtual platform and social media in facilitating knowledge-sharing among users.

Research limitations/implications
This study will benefit researchers and scholars in studying individual behavioral traits underpinning TPB in achieving organizational excellence.

Originality/value
This study extends the findings of the previous review because of their limitations on methods. This study confirms the determinants of knowledge-sharing intention and behavior. However, this study suggests integrating TPB with other theories to provide more insights into knowledge-sharing behavior and use online and technology-based platforms to facilitate knowledge-sharing behavior.
Corporate governance and financial inclusion
Authors: Ozili Peterson K. 
Published: May 2023

PurposeThis paper examines the association between corporate governance and financial inclusion in terms of correlation. This paper examines whether countries that have a strong corporate governance environment also experience better financial inclusion outcomes.Design/methodology/approachThe indicators of financial inclusion are automated teller machines (ATMs) per 100,000 adults, bank accounts per 1,000 adults and bank branches per 100,000 adults, while the indicators of corporate governance are extent of corporate transparency index, the extent of director liability index, the extent of disclosure index, the extent of ownership and control index, the extent of shareholder rights index, minority investors protection index and ease of shareholder suits index. The association was analyzed using Pearson correlation analysis and granger causality test.FindingsStrong corporate governance is significantly associated or correlated with better financial inclusion outcomes. The regional analyses show that corporate governance has a significant positive association with financial inclusion in Asian countries and in Middle East countries. However, a positive and negative association was observed between some indicators of corporate governance and financial inclusion in European countries, North American countries, South American countries, African countries and in Middle East and North Africa (MENA) countries, implying that strong corporate governance has a positive and negative association with financial inclusion depending on the indicators of corporate governance and financial inclusion used. There is also evidence of uni-directional granger causality between corporate governance and financial inclusion.Originality/valueLittle is known about the association between corporate governance and financial inclusion. This paper is the first to examine this association.
The links between financial depth and economic variables: evidence from Poland
Authors: Afzal Ayesha , Firdousi Saba Fazal , Mahmood Kamil 
Published: May 2023

PurposeThe purpose of this paper is to examine the relationship that exists between financial depth and economic growth in Poland for the years 1995–2019. This paper utilizes integration and co-integration techniques to capture the long-term and short-term linkages between various determinants of financial deepening, economic growth and a few selected growth variables. Financial depth is measured using two distinct measures: the monetization ratio (i.e. the ratio of broad money in the economy to the gross domestic product (GDP)) and the domestic credit provided to private sector by banks.Design/methodology/approachThe paper uses a combination of Augmented Dickey–Fuller (ADF) and Phillips–Perron unit root tests, autoregressive distributive lag (ARDL) model and Granger causality tests to estimate results.FindingsThis paper finds that there is a bidirectional causal relationship between financial deepening and economic growth in the short run, but this relationship does not hold in the long run. The control variables comprising trade volume, investment, government spending and volatility in oil prices and inflation have a significant, positive relationship with economic development in the long run.Originality/valueThe findings are indicative of the need for further strengthening of the financial sector in Poland, such that the relationship between financial depth and economic growth is substantiated in the long run. This paper also finds room for more stringent regulation of the financial system and transparency in information available.
Sailing the tide of over consumption: applying a business history approach to explore the rising demand of luxury yachts and travel since 1979
Authors: Connors Duncan Philip 
Published: May 2023

PurposeThe purpose of this paper is to identify how the socio-economic trends caused by the economic deregulation of the last four decades have led to a high-net-worth strata of individuals and families that conspicuously consumes luxury items and are the main customers in the luxury yacht market.Design/methodology/approachA selected cross-section review and discussion of relevant publications and theories within the field of tourism, social sciences, business and economic history are synthesised with relevant data to outline the factors leading to socio-economic change and conspicuous consumption.FindingsThis paper advocates for the synthesis of scholarly techniques found within the discipline of Business History to illuminate the development of a luxury yachting industry over the past four decades. Using the varieties of capitalism approach this paper demonstrates that the local characteristics of the BRIC (Brazil, Russia, India and China) in combination with the international globalisation and trade deregulation since 1980 has led to a new super wealthy class that engages in conspicuous consumption. Using a schema based on critical juncture theory, light has been shed on the specific factors underpinning the demand for luxury yachts as part of this conspicuous consumption.Originality/valueThis paper adds a new set of methodologies and theoretical tools to the student of luxury tourism that embed the practice within the context of socio-economic changes brought forth by economic globalisation since 1979, opening up new avenues of research.
Inferring geological structural features from geophysical and geological mapping data using machine learning algorithms
Authors: Xu Limin , Green Eleanor C. R. 
Published: May 2023

AbstractWe present an automated approach for inferring surface geological structures from geophysical survey data. Our method employs machine learning, using mapped geological structures as labels and filtered geophysical surveys as reference maps. We compared the performance of the eight main machine learning algorithms and their 32 branches. Applied to the Geological Survey of Victoria's database for the Bendigo Zone, following an appropriate choice of geological features, the 3‐class classification model using subspace K‐nearest neighbour methods achieves a stable and validated 92% accuracy in around 1 min. The fault‐only classification model achieves a stable and validated 97% accuracy in around 6 min. This shows that geological structural features on the surface may be inferred from between one and three of the following geophysical data types: gravity, airborne total magnetic intensity and first vertical derivative of total magnetic intensity. It shows the prospect of machine learning in geological research and suggests that geophysical data combined with machine learning may be useful and efficient in determining the existence of geological structural features.