bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of tribological behaviour of laser textured brake disc/composite brake pad system using adaptive neuro fuzzy interference system technique
Authors: Nadig Ravi Shankar , Bharatish A , Murthy H N Narasimha , Manoj I V , Vinod Prakash 
Published: June 2023

Abstract
This paper examines the impact of Laser Surface Texturing (LST) on the tribological performance of a commercial automotive brake system consisting of a metallic brake disc and composite brake pads. The study focuses on achieving an optimal combination of wear and friction, aligning with the goals of green technology. The Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) methodology is used to rank the characteristics, while the Adaptive Neuro Fuzzy Interference System (ANFIS) methodology is employed to model the friction and wear behavior of the brake pad-disc system under varying normal loads and sliding speeds. At a normal load of 100 N and a sliding speed of 0.73 m s−1 under dry conditions, the brake system exhibited a minimum coefficient of friction of 0.2066 and a specific wear rate of 7.93 × 10−6 mm3 N−1-m−1. Although, there was no specific correlation found between frictional power and specific wear rate, a higher load of 100 N and sliding speed of 2.71 m s−1 resulted in decrease in specific wear rate by 83% when compared to that of untextured brake discs. By applying brake oil to the laser-textured boundary, the coefficient of friction experienced a 31% reduction.
Effect of the deposition process on the stability of Ti3C2T
x
MXene films for bioelectronics
Authors: Shankar Sneha , Murphy Brendan B , Driscoll Nicolette , Shekhirev Mikhail , Valurouthu Geetha , Shevchuk Kateryna , Anayee Mark , Cimino Francesca , Gogotsi Yury , Vitale Flavia 
Published: June 2023

Abstract
Ti3C2T
x
MXene is emerging as the enabling material in a broad range of wearable and implantable medical technologies, thanks to its outstanding electrical, electrochemical, and optoelectronic properties, and its compatibility with high-throughput solution-based processing. While the prevalence of Ti3C2T
x
MXene in biomedical research, and in particular bioelectronics, has steadily increased, the long-term stability and degradation of Ti3C2T
x
MXene films have not yet been thoroughly investigated, limiting its use for chronic applications. Here, we investigate the stability of Ti3C2T
x
films and electrodes under environmental conditions that are relevant to medical and bioelectronic technologies: storage in ambient atmosphere (shelf-life), submersion in saline (akin to the in vivo environment), and storage in a desiccator (low-humidity). Furthermore, to evaluate the effect of the MXene deposition method and thickness on the film stability in the different conditions, we compare thin (25 nm), and thick (1.0 μm) films and electrodes fabricated via spray-coating and blade-coating. Our findings indicate that film processing method and thickness play a significant role in determining the long-term performance of Ti3C2T
x
films and electrodes, with highly aligned, thick films from blade coating remarkably retaining their conductivity, electrochemical impedance, and morphological integrity even after 30 d in saline. Our extensive spectroscopic analysis reveals that the degradation of Ti3C2T
x
films in high-humidity environments is primarily driven by moisture intercalation, ingress, and film delamination, with evidence of only minimal to moderate oxidation.
Effect of nano clay and PCE on the buildability of ultra-fine dredged sand-based 3D printing materials
Authors: Wang Fei , Hua Sudong , Chen Tingzhu , He Bijuan , Feng Guiyang , Li Siqi 
Published: June 2023

Abstract
The use of ultra-fine dredged sand instead of natural sand in construction 3D printing materials can significantly reduce the cost. However, ultra-fine dredged sand has fine particles and high angular morphology, which can hinder the buildability and continuous printability of construction 3D printing materials. The addition of polycarboxylate superplasticizer (PCE) can effectively solve this problem. Considering that the change of PCE (content of 0, 0.1%, 0.2%, 0.3%) content has a great influence on the printing performance of mortar, in order to make up for this deficiency, nano clay (content of 0,1%) is added to the mortar. The experimental results showed that the addition of nano clay can significantly reduce the negative effects of PCE on the yield stress and apparent viscosity of 3D printing materials (3DPM). When the content of PCE is 0.2%, the addition of 1% NAC could increase the static yield stress and viscosity growth rate of 3DPM by 111.8% and 115.3% respectively. In addition, unconfined compressive strength test, isothermal calorimetry, Mercury invasion porosity method and thermogravimetric analysis were used to characterize the hardening properties of 3DPM. The results of heat of hydration showed that the addition of nano clay reduced the hydration exothermic peak of 3DPM, but increased the total heat release. The results of pore structure analysis showed that the addition of nano clay reduced the macropore (>1000 nm) of 3DPM from 19.31% to 18.82%. Thermogravimetric analysis showed that the addition of nano clay increased the hydration products. Therefore, the compressive strength of 3DPM was kept within an acceptable range. Finally, the laboratory’s printing results indicated that the 3DPM can print up to 20 layers continuously.
Highly conductive laser-induced graphene through the deposition of liquid metal particles for flexible electronics
Authors: Tetik Halil , Markgraf Emmy , Kato Kohya , Chan Valerie N , Malakooti Mohammad H 
Published: June 2023

Abstract
The rapid and simple fabrication process of laser-induced graphene (LIG) has enabled the creation of flexible sensors for emerging applications such as wearable electronics and intelligent systems. Although LIG can be designed to be a sensitive strain sensor due to the large change in its resistance under deformation, this property can also limit its use as a printed conductor on flexible substrates. Here, we present a versatile technique to enhance the electrical conductivity and resistive heating ability of LIG for use as flexible conductors in printed electronics. The highly conductive traces are prepared by direct writing of LIG onto a polyimide film using a CO2 laser, upon which the functionalized liquid metal (LM)—eutectic gallium indium (EGaIn)—particles are deposited and activated. This results in a ∼400 times increase in electrical conductivity of LIG traces while maintaining mechanical flexibility and manufacturing scalability without the need for soldering. Electromechanical characterization of the LIG-LM traces shows low resistance change (less than 0.3 Ω) under large bending deformations. At the same time, the enhanced electrical conductivity contributes to the resistive heating performance as it reduces the input voltage requirement by ∼15 times to achieve similar surface temperatures compared to pure LIG traces. By combining EGaIn LM with laser-synthesized graphene, we can fabricate flexible hybrid electronics. We demonstrate the practicality of this technique by fabrication of flexible conductors and heating devices with highly customizable patterns.
Bridging the gap: the influence of information and education on acceptance of environmental taxes in Switzerland
Authors: Ruprecht Sophie 
Published: June 2023

Abstract
Mitigating climate change remains a challenge for politics since efficient instruments such as environmental taxes are widely unpopular, with one determinant of objection being a lack of knowledge. Trying to increase environmental tax acceptance, previous studies found positive, negative as well as no effects of information treatments about environmental taxes. Contributing to this inconclusive research, I apply MOSAiCH 2020 panel data from Switzerland, calculating the causal effect of receiving an environmental tax information treatment on willingness to pay them. While the information effect was inconsistent for the full sample, information significantly increases green tax acceptance of less educated people. This subgroup effect hence offers an explanation for previous inconsistencies by showing that information does not affect everyone equally. Especially for less educated people, receiving information about the functioning of environmental taxes might therefore prove crucial for policymakers to gain majority support of environmental taxes necessary for their implementation.
Prolegomena to Any Future Indigenous History of the Ancient World
Authors: LaBuff Jeremy 
Published: June 2023

Abstract
The usual way of talking about indigenous peoples in antiquity is to assume analogies between any peoples who were not hegemonic or imperial and the modern victims of European settler colonialism. The merits of such comparison are less often considered, and almost never from the perspective of the population described as “indigenous.” The aim of this article is to define and apply the term more carefully as a concept for premodern historians. A series of case studies from Hellenistic Anatolia illustrate how a casual use of “indigenous” leads to serious misunderstandings of imperial and colonial dynamics and indigenous self-understandings that can be rectified only by a theoretically grounded and transhistorical understanding of indigeneity. Such an approach forces us to examine the logic behind power relations and imbalances, leading to more fruitful comparison with the more familiar colonialism of the modern period.
An integrated deep learning framework for the interpretation of untargeted metabolomics data
Authors: Tian Leqi , Yu Tianwei 
Published: June 2023

Abstract
Untargeted metabolomics is gaining widespread applications. The key aspects of the data analysis include modeling complex activities of the metabolic network, selecting metabolites associated with clinical outcome and finding critical metabolic pathways to reveal biological mechanisms. One of the key roadblocks in data analysis is not well-addressed, which is the problem of matching uncertainty between data features and known metabolites. Given the limitations of the experimental technology, the identities of data features cannot be directly revealed in the data. The predominant approach for mapping features to metabolites is to match the mass-to-charge ratio (m/z) of data features to those derived from theoretical values of known metabolites. The relationship between features and metabolites is not one-to-one since some metabolites share molecular composition, and various adduct ions can be derived from the same metabolite. This matching uncertainty causes unreliable metabolite selection and functional analysis results. Here we introduce an integrated deep learning framework for metabolomics data that take matching uncertainty into consideration. The model is devised with a gradual sparsification neural network based on the known metabolic network and the annotation relationship between features and metabolites. This architecture characterizes metabolomics data and reflects the modular structure of biological system. Three goals can be achieved simultaneously without requiring much complex inference and additional assumptions: (1) evaluate metabolite importance, (2) infer feature-metabolite matching likelihood and (3) select disease sub-networks. When applied to a COVID metabolomics dataset and an aging mouse brain dataset, our method found metabolic sub-networks that were easily interpretable.
Preoperative planning for transaortic septal myectomy using cardiac computed tomography in patients with subaortic septal hypertrophy associated with aortic stenosis: case series
Authors: Shimahara Yusuke , Honda Sayaka , Fujiyoshi Toshiki , Kamiya Kentaro , Nakano Yu , Komatsu Ikki , Yamashita Jun , Ogino Hitoshi 
Published: June 2023

Abstract

Background
Electrocardiogram-gated cardiac computed tomography (CT) imaging enables a more accurate understanding of the patient’s cardiac anatomy. Preoperative planning for transaortic septal myectomy (TASM), based on cardiac CT, may be useful in patients with subaortic septal hypertrophy associated with severe aortic stenosis (AS).

Case summary
Two elderly patients (age &gt;80 years) with subaortic septal hypertrophy associated with AS underwent surgical aortic valve replacement (SAVR) and concomitant TASM after preoperative planning based on cardiac CT. Both patients showed subaortic septal hypertrophy with blood flow acceleration, left ventricular (LV) hypercontractility, and a short distance from the coaptation point of the mitral valve to the septum, resulting in possible dynamic LV outflow tract (LVOT) obstruction after resolution of AS. Optimal mid-diastolic images, selected from the 70–80% phase, were used for preoperative TASM planning. Planned sizes for myectomy based on multi-planar reconstruction were 10 × 26 × 9 mm (width × length × depth) and 10 × 25 × 9 mm for patient 1 and 2, respectively, while resected tissue size was 10 × 24 × 8 mm and 9 × 24 × 8 mm in patient 1 and 2, respectively. After TASM procedure, SAVR was performed with bioprosthetic valve. Postoperative course of both patients was uneventful with no evidence of complete atrioventricular block, septal perforation, or blood flow acceleration at the LVOT.

Discussion
Preoperative planning based on cardiac CT images is safe and useful for guiding adequate myectomy and preventing associated complications in patients with subaortic septal hypertrophy associated with AS.
The eroticization of sleep in the poetry of John Keats
Authors: Roberts Merrilees 
Published: June 2023

Abstract
I contend that in Keats’ poetry, sleep-states (rather than dreams) become a site of erotic intensity and power-play. Contemporary scientific literature such as Robert Gray’s The Theory of Dreams suggested that in sleep, ‘the senses, though capable of being aroused, are closed in insensibility’. I draw upon this thinking to show that through depictions of sleep, Keats creates a paradoxical, knowing eroticism where the senses are aroused even though the will is suspended. It is not that the continuum between dreaming and waking is eroticised, but that sleep becomes a highly controlled private space that is insistently open to sensory suggestion. By focusing on sleep as an embodied sensory experience, I show how in Keats’s work the uncoupling of agency and feeling creates an eroticism which tests the lines between surrender and consent, will and desire. Taking a new angle on what Byron considered to be a tendency towards euphemistic prurience in Keats’s writing, this essay also proposes that Keats’s interest in the erotic vulnerability of bodies to one another creates a negative capability, and an ethics, highly sensitised to the way the boundaries between self and world are maintained.
A2AR-mediated lymphangiogenesis via VEGFR2 signaling prevents salt-sensitive hypertension
Authors: Zhuang Tao , Lei Yu , Chang Jin-Jia , Zhou Yan-Ping , Li Yan , Li Yan-Xiu , Yang Yong-Feng , Chen Mei-Hua , Meng Ting , Fu Shi-Man , Huang Li-Hao , Cheang Wai-San , Cooke John P , Dong Zhi-Hui , Bai Ying-Nan , Ruan Cheng-Chao 
Published: June 2023

Abstract

Aims
Excess dietary sodium intake and retention lead to hypertension. Impaired dermal lymphangiogenesis and lymphatic dysfunction–mediated sodium and fluid imbalance are pathological mechanisms. The adenosine A2A receptor (A2AR) is expressed in lymphatic endothelial cells (LECs), while the roles and mechanisms of LEC–A2AR in skin lymphangiogenesis during salt-induced hypertension are not clear.

Methods and results
The expression of LEC–A2AR correlated with lymphatic vessel density in both high-salt diet (HSD)–induced hypertensive mice and hypertensive patients. Lymphatic endothelial cell–specific A2AR knockout mice fed HSD exhibited 17 ± 2% increase in blood pressure and 17 ± 3% increase in Na+ content associated with decreased lymphatic density (−19 ± 2%) compared with HSD-WT mice. A2AR activation by agonist CGS21680 increased lymphatic capillary density and decreased blood pressure in HSD-WT mice. Furthermore, this A2AR agonist activated MSK1 directly to promote VEGFR2 activation and endocytosis independently of VEGF as assessed by phosphoprotein profiling and immunoprecipitation assays in LECs. VEGFR2 kinase activity inhibitor fruquintinib or VEGFR2 knockout in LECs but not VEGF-neutralizing antibody bevacizumab suppressed A2AR activation–mediated decrease in blood pressure. Immunostaining revealed phosphorylated VEGFR2 and MSK1 expression in the LECs were positively correlated with skin lymphatic vessel density and A2AR level in hypertensive patients.

Conclusion
The study highlights a novel A2AR-mediated VEGF-independent activation of VEGFR2 signaling in dermal lymphangiogenesis and sodium balance, which might be a potential therapeutic target in salt-sensitive hypertension.
Maternal Epidermal Growth Factor Promotes Neonatal Claudin-2 Dependent Increases in Small Intestinal Calcium Permeability
Authors: Beggs Megan R , Young Kennedi , Plain Allen , O'Neill Debbie D , Raza Ahsan , Flockerzi Veit , Dimke Henrik , Alexander R Todd 
Published: June 2023

Abstract
A higher concentration of calcium in breast milk than blood favors paracellular calcium absorption enabling growth during postnatal development. We aimed to determine whether suckling animals have greater intestinal calcium permeability to maximize absorption and to identify the underlying molecular mechanism. We examined intestinal claudin expression at different ages in mice and in human intestinal epithelial (Caco-2) cells in response to hormones or human milk. We also measured intestinal calcium permeability in wildtype, Cldn2 and Cldn12 KO mice and Caco-2 cells in response to hormones or human milk. Bone mineralization in mice was assessed by μCT. Calcium permeability across the jejunum and ileum of mice were 2-fold greater at 2 wk than 2 mo postnatal age. At 2 wk, Cldn2 and Cldn12 expression were greater, but only Cldn2 KO mice had decreased calcium permeability compared to wildtype. This translated to decreased bone volume, cross-sectional thickness, and tissue mineral density of femurs. Weaning from breast milk led to a 50% decrease in Cldn2 expression in the jejunum and ileum. Epidermal growth factor (EGF) in breast milk specifically increased only CLDN2 expression and calcium permeability in Caco-2 cells. These data support intestinal permeability to calcium, conferred by claudin-2, being greater in suckling mice and being driven by EGF in breast milk. Loss of the CLDN2 pathway leads to suboptimal bone mineralization at 2 wk of life. Overall, EGF-mediated control of intestinal claudin-2 expression contributes to maximal intestinal calcium absorption in suckling animals.
New mutant alleles for Spargel/dPGC-1 highlights the function of Spargel RRM domain in oogenesis and expands the role of Spargel in embryogenesis and intracellular transport
Authors: Roy Swagota D , Nagarajan Sabarish , Jalal Md Shah , Basar Md Abul , Duttaroy Atanu 
Published: June 2023

Abstract
Energy metabolism in vertebrates is controlled by three members of the PGC-1 (PPAR γ− coactivator 1) family, transcriptional coactivators that shape responses to physiological stimuli by interacting with the nuclear receptors and other transcription factors. Multiple evidence now supports that Spargel protein found in insects and ascidians is the ancestral form of vertebrate PGC-1's. Here, we undertook functional analysis of srl gene in Drosophila, asking about the requirement of Spargel per se during embryogenesis and its RNA binding domains. CRISPR- engineered srl gene deletion turned out to be an amorphic allele that is late embryonic/early larval lethal and Spargel protein missing its RNA binding domain (SrlΔRRM) negatively affects female fertility. Overexpression of wild-type Spargel in transgenic flies expedited the growth of egg chambers. On the other hand, oogenesis is blocked in a dominant-negative fashion in the presence of excess Spargel lacking its RRM domains. Finally, we observed aggregation of Notch proteins in egg chambers of srl mutant flies, suggesting that Spargel is involved in intracellular transport of Notch proteins. Taken together, we claim that these new mutant alleles of spargel are emerging powerful tools for revealing new biological functions for Spargel, an essential transcription coactivator in both Drosophila and mammals.
Recombination and sterility in inversion homo- and heterokaryotypes under a general counting model of chiasma interference
Authors: Kapperud Øystein 
Published: June 2023

Abstract
It has long been known that the chiasmata are not independently distributed in most organisms, a phenomenon known as chiasma interference. In this paper, I suggest a model of chiasma interference that generalizes the Poisson model, the counting model, the Poisson-skip model, and the two-pathway counting model into a single framework, and use it to derive infinite series expressions for the sterility and recombination pattern probabilities in inversion homo- and heterokaryotypes, and a closed-form expression for the special case of the two-pathway counting model in homokaryotypes. I then use these expressions to perform maximum likelihood parameter estimations for recombination and tetrad data from various species. The results imply that the simpler counting models perform well compared to more complex ones, that interference works in a similar way in homo- and heterokaryotypes, and that the model fits well with data for the latter as well as the former. I also find evidence that the interference signal is broken by the centromere in some species, but not others, suggestions of negative interference in Aspergillus nidulans, and no consistent support for the theory that a second noninterfering chiasma pathway exists only in organisms that require double-strand break for synapsis. I suggest that the latter finding is at least partly due to issues involved in analyzing aggregate data from different experiments and individuals.
Irreducible ambiguity? The line between custom and statute in the law-making of thirteenth-century Poland
Authors: Górecki Piotr 
Published: June 2023

Abstract
A resurging subject today is medieval customary law and its boundary with statute. Regarding Poland, the inquiry is complicated by a historiographical consensus that here the law essentially was customary, supplemented by statute only in the later fourteenth century. This certainty has reduced legal reality to unwarranted uniformity. In response, I survey the terminology related to custom and statute, examine one document bridging that terminology and an enactment resembling a statute, and place that enactment in a long earlier legacy of written rule-making. This is not a sharp transition from custom to statute, but an evolving sequence of written expression.