bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new method for researching terramechanics problems of underwater tracked vehicles
Authors: Huang Weijian 
Published: May 2023

Abstract
In the process of mining the seabed resources, underwater tracked vehicles (UTVs) penetrate and shear the seabed during walking. Traditionally, the bevameter technique is widely chosen to research the above processes. However, the bevameter technique does not reflect the track-soil interaction, which includes ignoring the grousers’ effect in the penetration process and the connection between these two processes. In order to better simulate the track-soil interaction, here, a new method is proposed based on the torsional penetrometer that can integrate the penetration process and the shearing process into a continuous simulation, while the grousers’ effect is reflected. Furthermore, the corresponding formulas of key driving indicators are derived. To verify the validity of the new method, a set of comparative tests were carried out. The results indicated that the peak pressure of the new method was 20% bigger than those of the traditional method due to the consideration of the grousers’ effect, the peak shear stress and residual stress of the new method were respectively 33% and 30% bigger due to the continuous simulation, all of which showed the new method’s reliability and applicability.
Bilateral subcutaneous fatty flaps (BSF) for the treatment of recurrent pilonidal sinuses are a Novel technique superior to Z-plastics (ZP)
Authors: Saad Hassan A , Eraky Mohamed E , Elsayed Ashraf abdelmonem , Riad Mohamed , El-Taher Ahmed K , Elsayed Rasha S 
Published: May 2023

Abstract
Background:
Pilonidal disease has numerous management techniques available to surgeons worldwide. Because of the variety of clinical manifestations, several methods of intervention are needed; as a result, we hope for careful selection of the best technique for the patient's severity and recurrence.
Aim: To prevent possible recurrence after bilateral subcutaneous fatty flap(BSF), a novel method for treating pilonidal sinus illness and Z-Plasty(ZP) with fasciocutaneous flap.
Patients and methods:
All prospective patients having recurrent pilonidal sinus and operated on at our institute, Surgical Department from Jan. 2022 to Dec. 2023. In total, 50 cases have sacrococcygeal disease ( SCD), and 25 patients in Group A had bilateral subcutaneous fatty flap surgery. In contrast, the 25 patients in Group B were treated by Z-Plasty(ZP) with fasciocutaneous flap surgery. We assessed the length of the procedure, the level of postoperative pain, the length of the hospital stay, the postoperative complications, and the likelihood of recurrence.
Results:
The wound size was in the bilateral Subcutaneous fatty flap (BSF) 28.11 ± 8.48 mm relative to the (ZP) 23.84 ± 8.44 mm). Also, the complete healing was comparatively prolonged in the BSF (13days) relative to the ZP group (30 days). The surgery duration differs significantly (P < 0.001) between the groups; it was lower in the BSF group (29.15 ± 7.69 mins) than in the ZP (23.03 ± 6.06 mins). In the BSF group, the hospitalization was four days. Still, ZP group (11days), The time for work recovery or activity was shorter in the BSF (11 days) relative to the ZP group (36 days). BSF had more reasonable satisfaction than the ZP group, duration of wound healing in BSF being 11 days but in ZP 30 days. Additionally, the duration of pain in the group was ZP (38 days but in the BSF group (11 days).
Return to work in BSF 11 days and in ZP 36 days; The median satisfaction scores attained 8 (28.1%) in BSF and 9 (37%) in the ZP (P = 0.046). The median VAS scores attained 37.8% BSF and 44% for ZP (P = 0.934). The highest VAS score was equal to group B, which was 6.
Conclusion:
when treating pilonidal sinus disease, the bilateral subcutaneous fatty flap is superior to the ZP flap.
Effect of Manual Reduction Combined with Internal Fixation Through Wiltse Paraspinal Approach in the Treatment of Thoracolumbar Fracture (AO type A3)
Authors: Li Yang , Wu Ji , Gao Zhongya , Qiu Youcai , Zhang Jianjun , Yang Haisong , Lu Xuhua 
Published: May 2023

Abstract
Background: Thoracolumbar fractures (TF) are the most frequent fractures of the spine, and the current treatment for TF (AO Type A3) is the Wiltse approach with pedicle screw fixation or percutaneous pedicle screw fixation. However, secondary collapse often occurs after operation. To reduce the incidence of such events, preoperative manual reduction (MR) is an efficient method. The purpose of this study is to investigate the impact of successful PMR on prognosis of patients with TF.
Methods: From 2018 to 2022, 97 patients are enrolled to the study. Patients are divided into three groups, MR failure (MRF), succeeded (MRS) and instrument reduction (IR). The different time of the Cobb angel (CA) and vertebral body height ratio (VBHR) are obtained for three groups. The visual analog scale (VAS) is used to help patients assess the intensity of their pain, and oswestry disability index (ODI) is regarded as the gold standard for evaluating the degree of dysfunction caused by TF.
Results: The recovery of CA and VBHR, MRS and IR is significantly better than MRF at 2 days and 6 months after operation. The CA and VBHR are found to be different between preoperative and 2 days, 6 months after operation. The CA and VBHR in MRF are decreased at 6 months after surgery compared with 2 days after surgery. In the results of VBHR 6 months after operation, there is significant difference between MRS and IR.
Conclusion:
Successful preoperative manual reduction can greatly improve and maintain vertebral height and spinal physiological curvature. In addition, according to the success of manual reduction, TF of AO Type A3 can be divided into A3a and A3b.
Identification of anti-inflammatory mechanism of action and molecular targets of Hypericum perforatum in the treatment of major depression based on bioinformatics methods and machine learning
Authors: Xu Zewen 
Published: May 2023

Abstract
Background
Major depressive disorder (MDD) is one of the most common psychiatric disorders worldwide. The diagnosis and treatment of MDD is a major clinical issue. Hypericum perforatum (HP) is a traditional herb that has been shown to have antidepressant effects, but its mechanism is unclear. This study combined bioinformatics approach and molecular docking prediction to identify the mechanism of action and molecular targets of HP for the treatment of MDD from the perspective of signaling pathways and immune inflammation.
Methods
We performed differential analysis and weighted gene co-expression network analysis (WGCNA) with the GSE98793 depression expression dataset to intersect the identified DEGs and significant module genes to obtain intersection genes. Three databases, CTD, DisGeNET and GeneCards, were used to retrieve MDD-related gene intersections to obtain MDD predicted targets. The validated targets were retrieved from the TCMSP database. The enriched pathways were analyzed separately to obtain KEGGa, KEGGb and KEGGc. 13 key pathways were obtained by combining them. The PPI network was constructed by extracting the intersection of genes and HP validated targets on all key pathways. Five key therapeutic targets (AKT1, MAPK1, MYC, EGF, HSP90AA1) were obtained using MCODE and machine learning (LASSO, SVM-REF). Clinical diagnostic assessments (Nomogram, ROC, Correlation, Intergroup expression), gene set enrichment analysis (GSEA) were performed for the 5 key targets. In addition, immuno-infiltration analysis was performed on the MDD dataset to explore the regulatory mechanisms of the 5 key targets. Finally, molecular docking prediction was performed for the targets of HP active ingredients on MDD.
Results
Differential expression analysis and WGCNA module analysis yielded 933 potential targets for MDD. Three disease databases were intersected to 982 MDD predicted targets. The TCMSP retrieved 275 valid targets for HP. Separate enrichment analysis intersected to 13 key pathways. Five key targets (AKT1, MAPK1, MYC, EGF, HSP90AA1) were finally screened based on all enriched genes and HP valid targets. Combined with the signaling pathway and immune infiltration analysis, the effect of peripheral immunity on MDD and the important role of neutrophils in immune inflammation were investigated. Finally, the binding of HP active ingredients (quercetin, kaempferol and luteolin) and all 5 key targets was predicted based on molecular docking.
Conclusions
The active constituents (quercetin, kaempferol and luteolin) of Hypericum perforatum may act on MDD and its inflammatory symptoms through key targets (AKT1, MAPK1, MYC, EGF, HSP90AA1) and pathways such as neutrophil extracellular trap formation.
Innovation in education for quality of care: a scoping review
Authors: Sa Juliana , Zapata Tomas , Muscat Natasha Azzopardi , Breda Joao , Martins Henrique 
Published: May 2023

Abstract
Background:
Ensuring quality-of-care and promoting patient safety is a core competence that healthcare professionals are called to develop. Healthcare contexts are continuously changing advancing with social and technical innovations. The aim of this review is to identify innovative approaches in educational activities on quality of care, quality improvement and education about innovation for health professionals. Seeking evidence about educational strategies that are innovative or target innovation while addressing quality-of-care and quality improvement.
Methods:
A scoping review has been conducted searching for papers published between January 2000 and September 2022. Data bases used were PubMed, APA PsycInfo, SCOPUS, Web of Science and CINAHL using the terms “quality improvement”, “quality of care”, “education”, “teaching”, “innovation” and “healthcare”. Papers included characterized the state of quality training and described interventions on quality education in undergraduate and postgraduate training of healthcare professionals.
Results:
From the 2059 papers found, 11 were included in the study. Authors were mainly from USA and UK; most studies were about undergraduate training. Most interventions described the inclusion of Quality Improvement in the curricula. Papers were analyzed using a proposed innovation lens and classified accordingly. Seven papers were considered as Routine Innovations, one as (potentially) Disruptive, two as Radical and none as Architectural.
Conclusions:
There is a paucity of evidence on innovative educational approaches or education about innovation for quality-of-care, with few studies targeting quality improvement only. Most of the interventions were considered routine innovation. There is an urgent need to include quality-of-care training in undergraduate curricula and doing so in innovative ways; a model to advance this is presented.
Systematic study of the dynamics of liquid capillary rise within vertical microchannels
Authors: Sánchez-García Rubén E. , Castilleja-Escobedo Orlando , García-Cuéllar Alejandro , López-Salinas José L. 
Published: May 2023

Abstract
The study of capillary rise of different fluids in a capillary tube is analyzed using different experimental and mathematical methods and simulation with Computational Fluids Dynamics (CFD). Experimental tests are carried out, which in turn are compared with simplified mathematical models and CFD simulations trying to predict the same behavior of the experiments, discussing the similarities or differences found. Capillary forces or linear forces are assumed to have a significant impact on the process by neglecting gravitational forces. We find that for certain cases (depending on the time scale) the behavior can be favorable. Just as the properties of viscosity, interfacial tension and contact angle predominate in the behavior of fluids in the simulations, even the type of tube material also influences the behavior. Since if the material is hydrophilic or hydrophobic it drastically changes the conduction of the fluid, allowing you to be able to predict properties on site.
Epidemiological Patterns of Acute Type-A Aortic Dissection in Regional New South Wales - A 10-year Analysis
Authors: Rathnayake Ayeshmanthe , Chang Olivia , Narita Takuya , Mejia Rosauro 
Published: May 2023

Abstract
Background:
Acute Aortic Dissection (AD) is a surgical emergency with significant mortality without prompt diagnosis and operative intervention. The management is time critical and regional Australia represents an area of interest owing to its large distances and often paucity of resources. No previous studies examining Type-A AD in regional Australia have been done. The aim of this study is to illustrate the epidemiological trends in Type-A AD within a regional population of Australia. The primary outcomes are prevalence and mortality. The secondary outcomes are assessment of risk factors, challenges in diagnosis and associated complications.
Methods:
A retrospective analysis was undertaken in the Hunter New England (HNE) health district of New South Wales (NSW), Australia. We retrospectively examined data from 2010 to 2020 in the population of the Hunter New England health district. The data was analysed using Microsoft Excel and Statistical Package for Social Sciences (SPSS).
Results:
The prevalence of Type-A AD in the HNE was 1.47 per 100,000 and mortality was 2.12 per 100,000 which was lower compared to previous studies. Five percent of patients identified as Aboriginal and Torres Strait Islander. Combined risk factors of smoking and hypertension, postoperative CVA and misdiagnosis demonstrated higher mortality which were statistically significant (p < 0.05).
Conclusion:
This study is the first study to illustrate Type-A AD in regional Australia. The epidemiological trends, analysis and risk factor profiles present a solid foundation for future prospective studies to be based on to ultimately allow better patient outcomes.
Detecting Exoplanets in Multiplanetary Systems using HI Line Analysis through Gaussian Fitting
Authors: Dutta Pritam , Saraswat Rushil 
Published: May 2023

Abstract
The paper describes the detection of exoplanets in multiplanetary systems using HI line data is an approach in astronomy. Traditional methods for detecting exoplanets have limitations in terms of sensitivity and range, which makes it difficult to detect small and distant planets. We propose a mathematical model based on the analysis of the HI line emission and absorption spectra to predict the presence of exoplanets.The model is based on fitting the observed HI line profile to a Gaussian distribution f(v) = Aexp[−(v − vθ) 2 /(2δv2 )] + δf(v) where δf(v) is the perturbation caused by the exoplanet. The amplitude of the perturbation depends on the mass, orbital distance, and other properties of the exoplanet. and searching for significant deviations that may indicate the presence of an exoplanet.The chi-squared statistic,x 2 , measures the difference between the observed and expected HI line profiles: x 2 = P∞ n=1 2 −n = 1[fobs(v) − fexp(v)]2 /σ2 . The deviation caused by the exoplanet can be quantified using a perturbation term in the 19 Gaussian distribution. The amplitude of the perturbation depends on the mass, orbital distance, and other properties. We use statistical tests such as the chi-squared test to measure the significance of the deviation and estimate the properties of the exoplanet and the Extragalactic distance scale.
To explore the potential mechanism of Resveratrol against Helicobacter pylori based on network pharmacology, molecular docking, and molecular dynamics simulations Abstract
Authors: Li Yingzi , Hou Chou , Zhao Ailing , Liu Yipin Yipin 
Published: May 2023

Abstract
The global public health sector recognizes Helicobacter pylori (H. pylori) infection as a significant challenge, and its treatment largely relies on triple or quadruple therapy involving antibiotics. However, the emergence of antibiotic resistance compromises the effectiveness of these treatments. Resveratrol targets from well-known databases such as PubChem, TCMSP, TCMIP, and Swiss Target Prediction were integrated with H. pylori infection-related targets retrieved from GeneCards and OMIM databases to address this issue. By leveraging the STRING database, it is possible to identify the underlying target relationships and, thus, the core targets. The DAVID database was also used for Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of potential targets. In addition, AutoDock Vina is used for molecular docking, which facilitates the identification of interactions between core targets and active ingredients. GO analysis revealed involvement in reactive oxygen species metabolism, phosphatase binding, and protein serine/threonine kinase activity. KEGG pathway analysis suggests that Resveratrol may disrupt the invasion and persistence of Helicobacter pylori through vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF) pathways. Protein-protein interaction analysis identifies five core targets (AKT1, TP53, IL1B, TNF, and PTGS2), further validated through molecular docking and molecular dynamics (MD) simulation. This study explores the potential core targets and mechanisms of action of Resveratrol against Helicobacter pylori infection, offering novel insights for treating this infection.
Digital twin on the cloud: system-agnostic prediction of pharmaceutical placebo stability via computing-as-a-service and experimental validation
Authors: Antipas Georgios , Ntallis Nikolaos , Karalis Konstantinos , Miroslaw Loukasz 
Published: May 2023

Abstract
We applied computing-as-a-service to the unattended, system-agnostic, thermodynamic stability prediction of Vitamin E TPGS and Tween 80 pharmaceutical mixtures with a Copovidone VA64 polymer. The computing scheme involved a massively parallelized architecture for molecular dynamics and free energy perturbation from which binodal, spinodal and mechanical mixture critical points were detected on molar Gibbs free energy profiles at a hot melt extrusion temperature of 180 ˚C. We established tight agreement between the computed stability limits of 9.0 and 10.0 wt% vs. the experimental 7 and 9 wt% for the Vitamin E TPGS and Tween 80 systems, respectively, and determined different destabilizing mechanisms applicable to each system. This paradigm supports that computational stability screening may serve as a physically meaningful, resource-efficient, and operationally sensible digital twin to experimental stress-tests of pharmaceutical delivery systems.
MILLENIAL GENERATION SHOPPING BEHAVIOR IN BUYING IMPORTED HALAL LABELED FOOD PRODUCTS IN INDONESIA
Authors: Chalid Fitria Idham , Mirzal Husnul 
Published: May 2023

Abstrak: Penelitian ini bertujuan untuk menganalisis perilaku belanja generasi Milenial terhadap pembelian makanan impor berlabel halal. Penelitian ini menjadi penting mengingat maraknya produk multinasional yang mulai mendominasi pasar Indonesia, khususnya produk makanan halal. Metode yang digunakan adalah pendekatan kuantitatif dengan data primer dan sekunder. Teknik pengumpulan data yang digunakan adalah purposive sampling, sedangkan teknik analisis data yang digunakan adalah Structural Equation Modeling-Partial Least Square (SEM-PLS). Variabel yang digunakan dalam penelitian ini adalah citra merek, kesadaran halal, harga, niat beli, dan perilaku pembelian. Hasil penelitian menunjukkan bahwa citra merek berpengaruh terhadap perilaku pembelian, citra berpengaruh terhadap niat beli, kesadaran halal berpengaruh terhadap niat beli, harga berpengaruh terhadap perilaku beli, dan harga berpengaruh terhadap niat beli, sedangkan penelitian niat beli tidak berpengaruh terhadap perilaku beli. Hasil penelitian ini menunjukkan bahwa kesadaran halal, harga dan citra dapat mempengaruhi perilaku konsumen milenial dalam membeli produk penting berlabel halal. Selain itu, hasil ini akan memberikan kontribusi kepada pemerintah sebagai pembuat kebijakan untuk membatasi impor produk luar negeri yang masuk ke Indonesia, yang tentunya akan membuat produk dalam negeri kalah bersaing dengan produk impor.
Kata kunci: Generasi Milenial; Makanan Impor Berlabel Halal; SEM-PLS.

Abstract: This study aims to analyze the shopping behavior of the Millennial generation towards purchases imported food labeled halal. This research is important due to the increasment of multinational product which start to dominating Indonesian market, especially halal food products. The method used is quantitative approach with primary and secondary data. Purposive sampling is utilized for data collecting, and structural equation modeling-partial least squares is employed for data processing (SEM-PLS). Brand image, halal awareness, pricing, purchase intention, and purchasing behavior are the variables used in this study. The findings revealed that brand image affects purchase intention, image affects purchase behavior, halal knowledge affects purchase intention, pricing affects both buying behavior and purchase intention, and study on purchase intention has little impact on actual purchasing. The result of this study indicate that halal awareness, price and image can influence millennial customers behavior of buying important products labeled halal. In addition, this result will contribute to the government as the policy maker to limit imports of foreign products Entering Indonesia, which of course will make domestic products less competitive with imported products
Keywords: Milennial Generation; Imported Food Labelled Halal; SEM-PLS.
Turismo e Literatura - crise e resiliência em tempos de pandemia
Authors: Leites Diaz Ronaldo , Todeschini Ferreira Luciane 
Published: May 2023

A literatura caracteriza-se pelo convite à criação de realidades, provocando o leitor a viajar através do tempo e espaço, conduzindo-o a novos tempos e lugares, tornando o leitor um ser movente. Importante destacar que já há algum tempo vem se aproximando do Turismo, inclusive porque pode ser responsável pela promoção do nascimento do desejo de o leitor conhecer presencialmente os lugares que emergem das páginas dos livros (sendo que esse campo de estudos é abrangido pela Literatura de Turismo). Porém, essa é uma das perspectivas de aproximação entre turismo e literatura, outras ainda se fazem possíveis. Por também apresentar visões de mundo de uma determinada época e por produzir conhecimentos, a literatura pode auxiliar na compreensão de uma época, de uma sociedade. Este artigo tem por objetivo analisar, a partir de fragmentos literários, como a Pandemia de Cólera (1912) é retratada na obra “Morte em Veneza”, de Thomas Mann, a partir da relação da personagem Gustav Von Aschenbach, turista em Veneza, com o trade turístico do lugar. A pesquisa, de caráter qualitativo e de abordagem interpretativa, apoia-se nos estudos enunciativos bakhtinianos e literários para analisar a obra literária em questão. Na metodologia, buscou-se, a partir da seleção de extratos que apresentavam o cenário da pandemia, analisar como a mesma foi tratada e representada na narrativa. Na análise interpretativa, observa-se que a pandemia nesta obra surge como pano de fundo, permeando a forma das pessoas se relacionarem. A literatura, portanto, permite que sejam possíveis aproximações do passado com os dias atuais.