bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contemporary Treatment Paradigms are Associated with Improved Survival in Pancreatic Cancer
Authors: Kelly Bridget N. , Nicolais Laura , Mohamed Abdimajid , Fitzgerald Timothy L. 
Published: March 2023

Introduction Over the last decade, a paradigm shift has been made in treating pancreatic cancer. Starting in 2011, several trials demonstrated a survival advantage for multiagent chemotherapy (MAC). However, the implication for survival at the population level remains unclear. Methods A retrospective study of the National Cancer Database from 2006 to 2019 was conducted. Patients treated from 2006 to 2010 were classified as “Era 1”, and those treated from 2011 to 2019 as “Era 2.” Results A total of 316,393 patients with pancreatic adenocarcinoma were identified, with 87,742 treated in Era 1 and 228,651 in Era 2. Survival increased from Era 1 to Era 2 in all patients and sub-analyses; surgical (18.7 vs 24.6 months, HR .85, 95% CI 0.82-.88, P < .001), imminently resectable (Stage IA and IB, 12.2 vs 14.8 months, HR .90, 95% CI 0.86-.95, P < .001), high-risk (Stage IIA, IIB, and III, 9.6 vs 11.6 months, HR .82, 95% CI 0.79-.85, P < .001), and Stage IV (3.5 vs 3.9 months, HR .86, 95% CI 0.84-.89, P < .001). Survival was decreased for those who were African American ( P = .031), on Medicaid ( P < .001), or in the lowest quartile of annual income ( P < .001). Surgery rates decreased from 20.5% in Era 1 to 19.8% in Era 2 ( P < .001). Discussion Adoption of MAC regimens at a population level correlates with improved pancreatic cancer survival. Unfortunately, socioeconomic factors are associated with an unequal benefit from new treatment regimens, and underuse of surgery for resectable neoplasms persists.
Predicting suicide attempts among people with diabetes using a large multicenter electronic health records dataset
Authors: Narindrarangkura Ploypun , Alafaireet Patricia E. , Khan Uzma , Kim Min Soon 
Published: March 2023

Objective People with diabetes have a higher risk of suicidal behaviors than the general population. However, few studies have focused on understanding this relationship. We investigated risk factors and predicted suicide attempts in people with diabetes using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Method Data was retrieved from Cerner Real-World Data and included over 3 million diabetes patients in the study. LASSO regression was applied to identify associated factors. Gender, diabetes-type, and depression-specific LASSO regression models were analyzed. Results There were 7764 subjects diagnosed with suicide attempts with an average age of 45. Risk factors for suicide attempts in diabetes patients were American Indian or Alaska Native race ( β = 0.637), receiving atypical antipsychotic agents ( β = 0.704), benzodiazepines ( β = 0.784), or antihistamines ( β = 0.528). Amyotrophy was negatively associated with suicide attempts in males ( β = 2.025); in contrast, amyotrophy significantly increased the risk in females ( β = 3.339). Using a MAOI was negatively related to suicide attempts in T1DM patients ( β = 7.304). Age less than 20 was positively associated with suicide attempts in depressed ( β = 2.093) and non-depressed patients ( β = 1.497). The LASSO model achieved a 94.4% AUC and 87.4% F1 score. Conclusions To our knowledge, this is the first study to use LASSO regression to identify risk factors for suicide attempts in patients with diabetes. The shrinkage technique successfully reduced the number of variables in the model to improve the fit. Further research is needed to determine cause-and-effect relationships. The results may help providers to identify high-risk groups for suicide attempt among diabetic patients.
Relationship between perioperative cardiopulmonary bypass time, platelet count, fibrinogen level, rotational thromboelastometry data, antithrombin level, and blood loss volume and the effects of deep hypothermic circulatory arrest: An observational study
Authors: Kodaka M , Ichikawa J , Komori M 
Published: March 2023

Introduction We hypothesized that perioperative fibrinogen level, platelet count, and rotational thromboelastometry (ROTEM) data values decrease in proportion to cardiopulmonary bypass (CPB) time, particularly in patients who underwent deep hypothermic circulatory arrest (DHCA). Methods A total of 160 patients were enrolled and divided into the following three groups depending on CPB time: <2-h, 2– 3-h, and >3-h groups. Blood samples were obtained during CPB weaning. Platelet count, ROTEM data, fibrinogen level, and antithrombin level were determined. For propensity matching, we selected 15 patients who underwent DHCA and 15 patients who did not undergo DHCA and used propensity scores to match CPB time and other characteristics. Results The <2-h, 2–3-h, and >3-h groups included 74, 63, and 23 patients, respectively. No significant differences in platelet count and fibrinogen level were observed between the groups. Antithrombin level and amplitude of clot firmness at 10 min in the EXTEM and FIBTEM tests were lowest in the >3-h group. Similarly, blood loss volume and transfusion volume were highest in the >3-h group. Significant differences in platelet count, ROTEM data, lowest esophageal and bladder temperatures, and transfusion volume were observed between patients who underwent DHCA and patients who did not undergo DHCA. Conclusions The longer the CPB time, the greater the perioperative blood loss volume and transfusion volume, particularly if CPB time is greater than 3 hours. Sub-group analysis revealed that DHCA affects perioperative platelet count and function as well as blood loss volume.
Estimation Failure Risk by 0.5-mm Differences in Autologous Hamstring Graft Diameter in Anterior Cruciate Ligament Reconstruction: A Meta-analysis
Authors: Itoh Masafumi , Itou Junya , Okazaki Ken , Iwasaki Kiyotaka 
Published: March 2023

Background: Because grafts are made in 0.5-mm increments clinically for anterior cruciate ligament (ACL) reconstruction, it is important to clarify how the failure rate decreases as the diameter increases. Moreover, it is important to know whether even a slight increase in the graft diameter decreases the risk of failure. Hypothesis: The risk of failure decreases significantly with each 0.5-mm increase in hamstring graft diameter. Study Design: Meta-analysis; Level of evidence, 4. Methods: The systematic review and meta-analysis have estimated the diameter-specific failure risk for each 0.5-mm increase in ACL reconstruction using autologous hamstring grafts. We searched for studies describing the relationship between graft diameter and failure rate published before December 1, 2021, in leading databases, such as PubMed, EMBASE, Cochrane Library, and Web of Science, according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We included studies using single-bundle autologous hamstring grafts to investigate the relationship between failure rate and graft diameter of 0.5-mm intervals with >1-year follow-up. Then, we calculated the failure risk caused by 0.5-mm differences in autologous hamstring graft diameter. Assuming Poisson distribution for the statistical model, we employed an extended linear mixed-effects model in the meta-analyses. Results: Five studies containing 19,333 cases were eligible. The meta-analysis revealed that the estimated value of the coefficient of diameter in the Poisson model was −0.2357 with a 95% CI of −0.2743 to −0.1971 ( P < .0001). With every 1.0-mm increase in diameter, the failure rate decreased by 0.79 (0.76-0.82) times. In contrast, the failure rate increased by 1.27 (1.22-1.32) times for each 1.0-mm decrease in diameter. The failure rate significantly decreased with each 0.5-mm increase in graft diameter in the range of <7.0 to >9.0 mm from 3.63% to 1.79%. Conclusion: The risk of failure decreased correspondingly with each 0.5-mm increase in graft diameter in the range of <7.0 to >9.0 mm. Failure is multifactorial; however, increasing the graft diameter as much as possible to match each patient’s anatomic space without overstuffing is an effective precaution that surgeons can take to reduce failures.
Effect of bonding techniques on thermal insulation and biodegradation of banana fiber/recycled polyester nonwovens
Authors: N Muthukumar , G Thilagavathi , T Kiruba 
Published: March 2023

In this research, the needle punched and chemical bonded nonwovens were developed by blending banana fiber and recycled polyester (r-PET) in three blend ratios (90% banana/10% r-PET, 70% banana/30% r-PET, 50% banana/50% r-PET). The developed nonwovens were characterized by thermal insulation and biodegradation properties. Results showed that all developed nonwovens have an excellent insulation performance; the thermal resistance value is in the range of 0.299 to 0.248 m2K/W. It was observed that nonwovens made from 90% banana/10% r-PET have better thermal insulation compared to other blend ratios in both techniques. It was also observed that the chemical bonded nonwovens had a 6.69% higher thermal resistance value compared to the needle punched nonwovens. A bi-layer hybrid structure made with chemical bonded nonwoven and needle punched nonwoven provided a thermal resistance value of 0.43 m2K/W. The chemical bonded nonwovens showed lower biodegradation compared to needle punched nonwovens.
Influence of ballast bulk density and loading conditions on lateral resistance of concrete sleeper components
Authors: Aela Peyman , Jitsangiam Peerapong , Li Xinjie , Jing Guoqing 
Published: March 2023

From the perspective of the ballast railway track lateral stability, the sleeper-to-ballast interface has a vital role in the interaction between the sleeper and shoulder, crib, and base of the ballast layer. In this paper, ballast bulk density, vertical loading exerted by trains, and type of loading were considered as influencing factors on the variation of ballast components' contribution to the lateral resistance using the Discrete Element Method (DEM). For static tests, four vertical loadings of 0, 50, 100, and 150 kN, as well as three bulk densities of 1400, 1500, and 1600 kg/m3 of ballast, were prepared. For cyclic tests, four loading frequencies of 5, 10, 20, and 30 Hz were considered for a panel with a constant bulk density of 1500 kg/m3 subjected to 100 kN vertical loading. Simulations demonstrate that the lateral sleeper resistance is maximum when the ballast bulk density is approximately 1500 kg/m3.
Acceptance and Dropout Rates of Individuals with Asthma Approached in Self-management Interventions: A Systematic Review and Meta-analysis
Authors: Eilayyan Owis J. , Arafah Alaa M. 
Published: March 2023

Objective The objectives of this systematic review were to assess the acceptability of self-management interventions for people with asthma and identify contributing factors. Methods A systematic literature search was conducted using PubMed, MEDLINE, EMBASE (OVIDWEB), CINAHL and Cochrane databases. Clinical trials design was included if they met specified criteria. A random-effect meta-regression analysis was conducted to estimate the overall acceptance and drop-out rates and to assess the potential factors that may influence the outcomes. Results A total of 64 studies were included and 8,092 participants were recruited and participated in the trials. The estimated acceptance rate was 51.1%, while the estimated drop-out rates in the intervention and control groups were 18.2% and 15.6%, respectively. Lack of interest was the main reported reason for refusing to participate and dropping out from the program. Study-related and program-related factors influenced the acceptance and drop-out rates statistically and clinically. Conclusion The acceptance rate of self-management programs among asthmatic people was not high and the dropout rate was somewhat low. The review suggests optimizing the design of self-management studies and modifying the implemented self-management programs to increase the acceptance rate and decrease the dropout rate.
A systematic review of the psychometric properties of the sibling perception questionnaire
Authors: Gutierrez Abbigail , Horan Madeline , Limbers Christine A 
Published: March 2023

The purpose of this study was to perform a systematic review of the psychometric properties of the Sibling Perception Questionnaire (SPQ) in children with a sibling with a chronic illness. Full-text journal articles were located in APA PsycInfo and PubMed databases and by searching the reference lists of studies. Studies included reported on the psychometric properties of at least one domain of the SPQ in children under 18 years who had a sibling with a chronic health condition. Twenty-three studies met inclusion criteria. The quality of the evidence was assessed with the COSMIN Risk of Bias Checklist. None of the included studies reported on all 10 properties recommended by COSMIN and there was extensive variability in the quality of methods used to assess the psychometric properties of the SPQ across studies. The negative adjustment scale demonstrated the strongest internal consistency reliability across the studies included in the review. Eight studies assessed convergent validity, with all but one demonstrating the SPQ total score to be adequately correlated with like constructs. The studies included in the review provided preliminary support for the responsive of the SPQ in detecting clinically significant changes due to an intervention. Taken as a whole, findings from this review provide preliminary evidence for the SPQ as a reliable, valid, and responsive measure in children who have a chronically ill sibling. Future studies with stronger methodological quality and that assess test re-test reliability, known groups validity, and the factor structure of the SPQ are needed. This work did not receive any funding and the authors have no competing interests to declare.
Utilizing Scapula Retraction Exercises With or Without Glenohumeral Rotational Exercises With a Gradual Progression for Subacromial Pain Syndrome
Authors: Eraslan Leyla , Yar Ozan , Ergen Fatma Bilge , Huri Gazi , Duzgun Irem 
Published: March 2023

Background: Although exercise interventions are recommended in the management of subacromial pain syndrome (SPS), there is a lack of data regarding the exercises focusing on the principal biomechanical deficiencies that cause symptoms. Hypothesis: Utilizing progressive scapula retraction exercises (SRE) and glenohumeral rotation exercises (GRE) in the scapula stabilization program may lead to more reduction in symptoms and greater acromiohumeral distance (AHD) values. Study Design: A double-blind, randomized controlled trial. Level of Evidence: Level 2. Methods: A total of 33 patients were assigned randomly to either SRE or SRE+GRE. Both groups received a 12-week supervised rehabilitation program, including manual therapy and exercises (stretching and progressive scapula stabilization exercises). In addition, the SRE+GRE group performed GRE exercises at gradual elevation angles. From 12 to 24 weeks, patients performed exercise programs less frequently (3 times per week). Disability (shoulder pain and disability index [SPADI]), AHD (at 5 active abduction angles), pain intensity (visual analogue scale [VAS]), and patient satisfaction were recorded at baseline, 12 weeks, and 24 weeks. A total of 16 healthy individuals were recruited as a control group to compare AHD values. Data were analyzed using mixed model analyses of variance. Results: A statistically significant group-by-time interaction was found for AHD values ( F4,92 = 6.38; P = 0.001), a significant group-by-time interaction for SPADI-disability ( F1,33 = 5.148; P = 0.01), SPADI-total ( F1,32 = 4.172; P = 0.03), and for pain during activity ( F2,62 = 3.204; P = 0.05). However, no significant group-by-time interaction for SPADI-pain (F1,33 = 0.533; P = 0.48), for pain at rest (F1,31 < 0.001; P = 0.99), and at night (F1,32 = 2.166; P = 0.15). Yet, a significant time effect was observed. Conclusion: Progressive SRE and GRE in the scapula stabilization program lessens symptoms and improves AHD values in patients with SPS. Moreover, this program could preserve outcomes and further increase AHD when applied less frequently. Clinical Relevance: Utilizing SRE and GRE in the scapula stabilization program at gradual shoulder abduction angles provides better rehabilitation outcomes.
Application of 3D Modeling Software to Preoperative MRI for Prediction of Surface Area of Tissue Applied During Osteochondral Allograft Reconstruction of the Knee
Authors: Moulton Samuel G. , Provencher Matthew , Vidal Armando , Wiedrick Jack , Arnold Kaytee , Crawford Dennis 
Published: March 2023

Background: Preoperative magnetic resonance imaging (MRI) is used to estimate the quantity of tissue provided for fresh osteochondral allograft (FOCA) in the knee. Use of 3-dimensional (3D) MRI modeling software for this purpose may improve defect assessment, providing a more accurate estimate of osteochondral allograft tissue required and eliminating the possibility of acquiring an inadequate quantity of tissue for transplant surgery. Purpose: To evaluate the capacity of damage assessment (DA) 3D MRI modeling software to preoperatively estimate the osteochondral allograft surface area used in surgery. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Included were 36 patients who had undergone FOCA surgery to the distal femur. Based on the preoperative MRI scans, the DA software estimated the total surface area of the lesion as well as the surface areas of each subarea of injury: full-thickness cartilage injury (International Cartilage Repair Society [ICRS] grade 4), partial-thickness cartilage injury (ICRS grade 2-3), bone marrow edema, bone loss, and bone cyst. The probability of overestimation of graft tissue areas by the DA software was calculated using a Bayes-moderated proportion, and the relationship between the prediction discrepancy (ie, over- or underestimation) and the magnitude of the DA estimate was assessed using nonparametric local-linear regression. Results: The DA total surface area measurement overestimated the actual area of FOCA tissue transplanted 81.6% (95% CI, 67.2%-91.4%) of the time, corresponding to a median overestimation of 3.14 cm2, or 1.78 times the area of FOCA transplanted. The DA software overestimated the area of FOCA transplanted 100% of the time for defect areas measuring >4.52 cm2. For defects <4.21 cm2, the maximum-magnitude underestimation of tissue area was 1.45 cm2 (on a fold scale, 0.63 times the transplanted area); a plausible heuristic is that multiplying small DA-measured areas of injury by a factor of ∼1.5 would yield an overestimation of the tissue area transplanted most of the time. Conclusion: The DA 3D modeling software overestimated osteochondral defect size >80% of the time in 36 distal femoral FOCA cases. A policy of consistent but limited overestimation of osteochondral defect size may provide a more reliable basis for predicting the minimum safe amount of allograft tissue to acquire for transplantation.
Punctuated growth of InAs quantum dashes-in-a-well for enhanced 2-μm emission
Authors: Chu R. J. , Kim Y. , Woo S. W. , Choi W. J. , Jung D. 
Published: March 2023

AbstractInAs quantum dashes (Qdash) engineered to emit near 2 μm are envisioned to be promising quantum emitters for next-generation technologies in sensing and communications. In this study, we explore the effect of punctuated growth (PG) on the structure and optical properties of InP-based InAs Qdashes emitting near the 2-μm wavelength. Morphological analysis revealed that PG led to an improvement in in-plane size uniformity and increases in average height and height distribution. A 2 × boost in photoluminescence intensity was observed, which we attribute to improved lateral dimensions and structural stabilization. PG encouraged formation of taller Qdashes while photoluminescence measurements revealed a blue-shift in the peak wavelength. We proposed that the blue-shift originates from the thinner quantum well cap and decreased distance between the Qdash and InAlGaAs barrier. This study on the punctuated growth of large InAs Qdashes is a step toward realizing bright, tunable, and broadband sources for 2-μm communications, spectroscopy, and sensing.
Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma
Authors: Meng Ming , Zhang Xia , Li Qian , Han Jingjing , Chen Yu , Qiao Haishi , Yang Yonglin , Huang Xin 
Published: March 2023

AbstractFerroptosis represents an innovative strategy to overcome the resistance of traditional cancer therapeutic through lethal lipid peroxidation leading to immunogenic cell death. However, the inefficiency of ferroptosis inducers and mild immunogenicity restrict the further clinical applications. Herein, engineering exosome-mimic M1 nanovesicles (MNV) were prepared by serial extrusion of M1 macrophage and served as an efficient vehicle for docosahexaenoic acid (DHA) delivery. MNV loaded with DHA (MNV@DHA) could promote more DHA accumulation in tumor cells, depletion glutathione and reduction of lipid antioxidant glutathione peroxidase-4 facilitating the occurrence of ferroptosis. Furthermore, MNV were able to induce the polarization of M1 and repolarize M2 macrophages to activate tumor immune microenvironments. The activated immune cells would further trigger the ferroptosis of tumor cells. In a murine orthotopic hepatocellular carcinoma model, MNV@DHA could significantly target tumor tissues, increase the proportion of M1 macrophages and CD8+ T cells and lessen the infiltration of M2 macrophages. Accordingly, MNV@DHA characterized with positive feedback regulation between ferroptosis and immune activation exhibited the strongest in vivo therapeutic effect. The synergism of ferroptosis and immunomodulation based on the dietary polyunsaturated fatty acids and engineered exosome-mimic nanovesicles may serve as a promising modality to efficiently complement pharmacological approaches for cancer management.