bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global analysis of lysine acetylation in the brain cortex of K18‐hACE2 mice infected with SARS‐CoV‐2
Authors: Wang Qiaochu , Peng Wanjun , Yang Yehong , Wu Yue , Han Rong , Ding Tao , Zhang Xutong , Liu Jiangning , Liu Jiangfeng , Yang Juntao 
Published: June 2023

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has infected hundreds of millions of people all over the world and thus threatens human life. Clinical evidence shows that SARS‐CoV‐2 infection can cause several neurological consequences, but the existing antiviral drugs and vaccines have failed to stop its spread. Therefore, an understanding of the response to SARS‐CoV‐2 infection of hosts is vital to find a resultful therapy. Here, we employed a K18‐hACE2 mouse infection model and LC‐MS/MS to systematically evaluate the acetylomes of brain cortexes in the presence and absence of SARS‐CoV‐2 infection. Using a label‐free strategy, 3829 lysine acetylation (Kac) sites in 1735 histone and nonhistone proteins were identified. Bioinformatics analyses indicated that SARS‐CoV‐2 infection might lead to neurological consequences via acetylation or deacetylation of important proteins. According to a previous study, we found 26 SARS‐CoV‐2 proteins interacted with 61 differentially expressed acetylated proteins with high confidence and identified one acetylated SARS‐CoV‐2 protein nucleocapsid phosphoprotein. We greatly expanded the known set of acetylated proteins and provide the first report of the brain cortex acetylome in this model and thus a theoretical basis for future research on the pathological mechanisms and therapies of neurological consequences after SARS‐CoV‐2 infection.
Changes in the herbicide sensitivity and competitive ability of Abutilon theophrasti over 28 years: Implications for hormesis and weed evolution
Authors: Ethridge Sandra R. , Chandra Saket , Locke Anna M. , Everman Wesley J. , Jordan David L. , Owen Micheal D.K. , Leon Ramon G. 
Published: June 2023

AbstractBACKGROUNDThe potential of weed species to respond to selection forces affecting the evolution of weedy traits such as competitive ability is poorly understood. This research characterized evolutionary growth changes in a single Abutilon theophrasti Medik. population comparing multiple generations collected from 1988 to 2016. A competition study was performed to understand changes in competitive ability, and a herbicide dose–response study was carried out to assess changes in sensitivity to acetolactate synthase‐inhibiting herbicides and glyphosate over time.RESULTSWhen grown in monoculture, A. theophrasti biomass production per plant increased steadily across year‐lines while leaf number decreased. In replacement experiments, A. theophrasti plants from newer year‐lines were more competitive and produced more biomass and leaf area than the oldest year‐line. No clear differences in sensitivity to imazamox were observed among year‐lines. However, starting in 1995, this A. theophrasti population exhibited a progressive increase in growth in response to a sublethal dose of glyphosate (52 g a.e. ha−1), with the 2009 and 2016 year‐lines having more than 50% higher biomass than the nontreated control.CONCLUSIONThis study demonstrates that weeds can rapidly evolve increased competitive ability. Furthermore, the results indicate the possibility of changes in glyphosate hormesis over time. These results highlight the importance of the role that rapid (i.e., subdecadal) evolution of growth traits might have on the sustainability of weed management strategies. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Bavachinin selectively modulates PPAR γ and maintains bone homeostasis in Type 2 Diabetes
Authors: Liu Jingwen , Li Xiaoye , Wang Hong , Ren Yan , Li Yiming , Guo Fujiang 
Published: June 2023

AbstractFull peroxisome proliferator‐activated receptor (PPAR) γ agonists, Thiazolidinediones (TZDs), effectively prevent the process of Type 2 Diabetes Mellitus (T2DM), but their side effects have curtailed use in the clinic, including weight gain and bone loss. Here, we identified that a selective PPAR γ modulator, Bavachinin (BVC), isolated from the seeds of Psoralea Corylifolia L., could potently regulate bone homeostasis. MC3T3‐E1 pre‐osteoblast cells and C3H10T1/2 mesenchymal stem cells were assessed for osteogenic differentiation activities, and receptor activator of NF‐κB ligand (RANKL)‐induced RAW 264.7 cells were assessed osteoclasts formation. Leptin receptor‐deficient mice and diet‐induced obesity mice were applied to evaluate the effect of BVC on bone homeostasis in vivo. Compared to full PPAR γ agonist rosiglitazone, BVC significantly increased the osteogenesis differentiation activities under normal and high glucose conditions in MC3T3‐E1 cells. Moreover, BVC could alleviate osteoclast differentiation in RANKL‐induced RAW 264.7 cells. In vivo, synthesized BVC prodrug (BN) has been applied to improve water solubility, increase the extent of oral absorption of BVC and prolong its residence time in blood circulation. BN could prevent weight gain, ameliorate lipid metabolism disorders, improve insulin sensitivity, and maintain bone mass and bone biomechanical properties. BVC, a unique PPAR γ selective modulator, could maintain bone homeostasis, and its prodrug (BN) exhibits insulin sensitizer activity while circumventing the side effects of the TZDs, including bone loss and undesirable weight gain.
Direct Blood Cell Flow Imaging in Microvascular Networks
Authors: Kim Gyounghwan , Park Hyun‐Sang , Shin Paul , Eom Taeguk , Yoon Jin‐Hui , Jeong Yong , Oh Wang‐Yuhl 
Published: June 2023

AbstractBlood flow dynamics in microvascular networks are intimately related to the health of tissues and organs. While numerous imaging modalities and techniques have been developed to assess blood flow dynamics for various applications, their utilization has been hampered by limited imaging speed and indirect quantification of blood flow dynamics. Here, direct blood cell flow imaging (DBFI) is demonstrated that provides visualization of individual motions of blood cells over a field of 0.71 mm × 1.42 mm with a time resolution of 0.69 ms (1450 frames s−1) without using any exogenous agents. DBFI enables precise dynamic analysis of blood cell flow velocities and fluxes in various vessels over a large field, from capillaries to arteries and veins, with unprecedented time resolution. Three exemplary applications of DBFI, quantification of blood flow dynamics of 3D vascular networks, analysis of heartbeat induced blood flow dynamics, and analysis of blood flow dynamics of neurovascular coupling, illustrate the potential of this new imaging technology.
Strategies for Improving the Photocatalytic Hydrogen Evolution Reaction of Carbon Nitride‐Based Catalysts
Authors: Chu Xueze , Sathish C.I. , Yang Jae‐Hun , Guan Xinwei , Zhang Xiangwei , Qiao Liang , Domen Kazunari , Wang Shaobin , Vinu Ajayan , Yi Jiabao 
Published: June 2023

AbstractDue to the depletion of fossil fuels and their‐related environmental issues, sustainable, clean, and renewable energy is urgently needed to replace fossil fuel as the primary energy resource. Hydrogen is considered as one of the cleanest energies. Among the approaches to hydrogen production, photocatalysis is the most sustainable and renewable solar energy technique. Considering the low cost of fabrication, earth abundance, appropriate bandgap, and high performance, carbon nitride has attracted extensive attention as the catalyst for photocatalytic hydrogen production in the last two decades. In this review, the carbon nitride‐based photocatalytic hydrogen production system, including the catalytic mechanism and the strategies for improving the photocatalytic performance is discussed. According to the photocatalytic processes, the strengthened mechanism of carbon nitride‐based catalysts is particularly described in terms of boosting the excitation of electrons and holes, suppressing carriers recombination, and enhancing the utilization efficiency of photon‐excited electron–hole. Finally, the current trends related to the screening design of superior photocatalytic hydrogen production systems are outlined, and the development direction of carbon nitride for hydrogen production is clarified.
Brandbemessung von Stahltragwerken mit der Finite‐Elemente‐Methode
Authors: Lequime Pascal 
Published: June 2023

AbstractBrandschutztechnisch komplett ungeschützte Stahlkonstruktionen sind in der Baupraxis nicht etabliert. Insbesondere in Verbindung mit Verbunddecken lassen sich mit erweiterten Finite‐Elemente‐Modellen jedoch oft ungeschützte Stahlkonstruktionen realisieren. Falls durch die Bemessung kein Wegfall der Brandschutzmaßnahmen möglich ist, können diese optimiert werden, z. B. hinsichtlich der Schichtdicken von dämmschichtbildenden Brandschutzanstrichen. Analytische Methoden oder vereinfachte Verfahren resultieren in der Praxis meist in Konstruktionen mit eher konservativen Brandschutzmaßnahmen und vernachlässigen physikalische Phänomene wie z. B. die thermischen Dehnungen und Zwängungen. Im vorliegenden Aufsatz wird die Bemessung im Brandfall mit numerischen Methoden und dem Fokus auf die praktische Anwendung dargestellt. Zur Beurteilung werden Tragfähigkeitskriterien mithilfe des Spannungs‐Dehnungsverhaltens der Werkstoffe und der Schrauben angesetzt. Die praktische Anwendung von Finite‐Elemente‐Modellen wird anhand ausgewählter Beispiele mit Teilsystemen oder Einzelbauteilen gezeigt – sowohl mit dem Ziel des kompletten Verzichts auf Brandschutzmaßnahmen als auch einer Optimierung der Schichtdicken dämmschichtbildender Brandschutzanstriche.
Establishment of green graphite industry: Graphite from biomass and its various applications
Authors: Shi Ziyi , Wang Shule , Jin Yanghao , Zhao Lingfeng , Chen Shiwei , Yang Hanmin , Cui Yuxiao , Svanberg Rikard , Tang Chuchu , Jiang Jianchun , Yang Weihong , Jönsson Pär G. , Han Tong 
Published: June 2023

AbstractResource‐ and energy‐efficient biomass exploitation for green graphite production is one of the most effective strategies for satisfying graphite demand while minimizing energy consumption and carbon emissions. This study investigated green graphite production from biomass waste and its applications to establish a green graphite industry. Biomass pyrolysis and catalytic graphitization of biochar were studied first to produce green graphite. The optimized green graphite exhibited a reversible capacity of 264 mA h/g and 97% capacity retention over 100 cycles in a half‐cell. Green graphite electrodes with a resistivity lower than 5 μΩ m were fabricated by using organic fraction bio‐oil as a green binder. Other green graphite applications, including printing, conductive printing, pencils, and refractories, were also achieved. The overall process of graphite anode and electrode synthesis from biomass waste and short‐rotation energy crops was modeled. Approx. 95 kg of battery graphite or 109 kg of metallurgical graphite electrodes can be produced per ton of biomass with low primary energy consumption and carbon footprint. Prominently, the modeling result and life cycle assessment demonstrated that, for the production of battery graphite from biomass waste, net‐negative‐CO2 emissions (−0.57 kg CO2‐eq/kg graphite powders) with net‐negative‐primary energy consumption (−28.31 MJ/kg graphite powders) was achieved.
Comparison of clinical cure rates from footrot and contagious ovine digital dermatitis using zinc sulphate foot bathing and topical oxytetracycline: A randomised trial
Authors: Jackson Alana , Grove‐White Dai H. , Angell Joseph W. , Duncan Jennifer S. 
Published: June 2023

AbstractBackgroundThis study reports the clinical cure rates of topical oxytetracycline and 10% zinc sulphate foot bathing for treatment of interdigital dermatitis (ID), footrot (FR) and contagious ovine digital dermatitis (CODD) in lambs.MethodsThe study was a randomised controlled trial of 75 lambs. Group A (n = 38) was foot bathed daily for 5 days in 10% zinc sulphate for 15 minutes and group B was treated with daily topical oxytetracycline for 5 days. On days 0, 7, 14, 28 and 42, lambs were scored for locomotion and foot lesions were recorded.ResultsThe initial cure rates for ID were 96.20% and 97.00%; for FR, 100% and 95%; and for CODD, 90.09% and 83.33% for zinc sulphate and oxytetracycline, respectively. By day 42, these had changed to 53.16% and 61% for ID; 47.82% and 70% for FR; and 100% and 83.33% for CODD. There were no significant differences in cure rates between the treatments for most time points.LimitationsThe sample size was small, and further studies in larger cohorts and different classes of sheep are required before the findings can be translated into recommendations for clinical practice.ConclusionBoth treatments achieved cure rates that are comparable to reported cure rates using systemic antibiotics and could be an effective alternative.
Association of Fish and Wildlife Agencies' perspectives on lead, alternative ammunition, and wildlife management
Authors: Mawdsley Jonathan , Johansen Paul 
Published: June 2023

AbstractBetween 1970 and 2010, the Association of Fish and Wildlife Agencies (AFWA) approved 7 resolutions and one position statement related to lead, alternative ammunition, and wildlife management. The resolutions and statement address the following topics: transitioning from lead to nonlead shot for waterfowl hunting; addressing concerns relating to lead mobility at outdoor shooting ranges; and developing guiding principles for the future regulation of lead ammunition. We provide a brief overview of AFWA's committee structure and decision‐making processes, and also note the presence of ongoing discussions about lead ammunition in the AFWA Fish and Wildlife Health Committee and the AFWA Lead and Fish and Wildlife Health Working Group.
Exploring the utility, limitations, and possibilities of the leadership identity development (LID) model
Authors: Bitton Adrian L. , Devies Brittany , Hassell‐Goodman Sharrell , Shetty Rebecca , Owen Julie E. 
Published: June 2023

AbstractThe article summarizes a conversation with early career scholars who utilize the LID theory and model in their scholarship and practice. Authors offer thoughts as to which aspects of leader and leadership identity development remain most useful to leadership education and development, as well as ways this body of scholarship might also be incomplete and insufficient. They reflect on how leader and leadership identity development theorizing is related to identity, equity, and power. The article concludes with ideas about how the scholarship and practice of leadership identity development may evolve in the future for deeper leadership identity development.
Boosting Employability Through Fostering an Entrepreneurial Mindset: Critical Analysis of Employability and Entrepreneurship in EU Policy Documents
Authors: Laalo Hanna , Kinnari Heikki , Silvennoinen Heikki , Haltia Nina 
Published: June 2023

AbstractIn EU higher education policy, improving graduate employability is a central concern, setting guidelines and putting pressure not only on higher education institutions but also on individuals. In this chapter, the policy discourse on producing employable graduates is analysed by considering entrepreneurship education as a governing technology. The analysis illustrates how entrepreneurship education is represented as an empowering solution to maximise graduates’ employment and economic potential. Graduates are within the policy being governed by risk. While the goal of the policy appears to be producing empowered and employable graduates with a self-responsible entrepreneurial mindset, the policy might also set unintentional pressures and participate in generating a character of a ‘neurotic citizen’ who has a constant fear of losing control in life and dropping out from society.
Das Leibliche Selbst
Authors: Ekweariri Dominic Nnaemeka 
Published: June 2023

ZusammenfassungIn diesem Kapitel behandeln wir Richirs Phänomenologie des Selbst, die auf zwei Stufen aufbaut. Im ersten Schritt wendet sich Richir gegen all diejenigen Theorien des Selbst, die als „leiblose“ Ideale zusammengefasst werden können und die durch das Prisma einer metaphysischen Hyperbel (Heidegger, Levinas, Binswanger) denkbar sind. Im zweiten Schritt folgt Richir Husserl, um die transzendentale Geschichte des Selbst zu verteidigen. Hier wird das Konzept des Leibes unvermeidlich, wenn man alle Schwierigkeiten, Ambiguitäten und Rätsel der ersten Stufe, also des leiblosen Selbst, abbauen muss. Im Rahmen dieses zweiten Schrittes, in dem das Register des primordialen Leibes als Basis der Erfahrung und der Orientierung im Raum durch die Einfühlung (die Introjektion der transzendentalen Intersubjektivität) aktiviert wird, vertrete ich als erste These, dass das Selbst als Leib-Körper eine unmögliche Möglichkeit ist. Mit dieser Bezeichnung, die für ein Zeichen des Überschusses in der Erfahrung steht, argumentiere ich im Anschluss an Husserls physisch-psychische Einheit des Menschen, dass das Selbst aus der lückenhaften Einheit zwischen einem Nichtdarstellbaren und einem Darstellbaren, einer Unmöglichkeit und einer Möglichkeit besteht. Ich argumentiere, dass der Phantasieleib im Abstand zwischen der Unmöglichkeit und der Möglichkeit ein „Nichtgegebenes“ empfindet und so ein kommunikatives Verhältnis zwischen den Leibern ermöglicht. Weiter vertrete ich die zweite These, dass die oben genannte Unmöglichkeit im Hinblick auf das leibliche Selbst und die Möglichkeit im Hinblick auf das Körperding verstanden werden kann. Das leibliche Selbst bleibt für uns unmöglich, insofern es ein Träger des Sinns ist; jedoch ist es als Körperding erst innerhalb der Bedeutung (in einem Sprachsystem) möglich. Mit dem Begriff des Phantomleibs werden eine mögliche Täuschung des Selbst und eine Sinnlosigkeit behandelt. Nur so können alle von Richir erhobenen Vorwürfe von Richir gegen ein „ideales Selbst“ konsistent aufgehoben werden.
Versorgung von Menschen mit Seltenen Erkrankungen: Empfehlungen für eine gelungene intersektorale Zusammenarbeit
Authors: Inhestern Laura , Brandt Maja , Otto Ramona , Zybarth David , Härter Martin , Bergelt Corinna 
Published: June 2023

Zusammenfassung
Hintergrund
Seltene Erkrankungen (SE) sind häufig durch komplexe Beschwerdebilder charakterisiert und erfordern in der Regel im Diagnose- und Versorgungsverlauf die Zusammenarbeit von spezialisierten Zentren und Primärversorgenden. Reibungslose Schnittstellen mit geringem Informationsverlust und Kooperation stellen daher eine essenzielle Grundlage in der Versorgung dar. Das Projekt „Evaluation von Schnittstellenmanagementkonzepten bei Seltenen Erkrankungen“ (ESE-Best) verfolgte mittels verschiedener Erhebungsinstrumente das Ziel, Empfehlungen für die Gestaltung und Umsetzung von Schnittstellen in der Versorgung von Menschen mit Seltenen Erkrankungen zu entwickeln.

Methoden
Es wurden mittels quantitativer und qualitativer Befragungen die Perspektiven der Zentren für Seltene Erkrankungen (ZSE), der Primärversorgung und der Betroffenen (Patient:innen, Eltern) erfragt sowie 2 Expert:innen-Workshops durchgeführt.

Ergebnisse
Es wurden insgesamt 28 Empfehlungen in den folgenden 5 Bereichen formuliert: 1) Vernetzung zwischen Primärversorgung und Zentren für Seltene Erkrankungen (ZSE), 2) Schnittstellen innerhalb der ZSE, 3) Bekanntheit von Seltenen Erkrankungen, ZSE-Strukturen und Zuständigkeiten, 4) Schnittstellen zwischen ZSE und Patient:innen sowie 5) weiterführende Empfehlungen.

Diskussion
Die Empfehlungen sollen zukünftig zu einem funktionierenden Schnittstellenmanagement bei der Versorgung von Menschen mit Seltenen Erkrankungen beitragen. Da die Erfahrungswerte von Primärversorgenden, ZSE und Betroffenen in die Entwicklung der Empfehlungen eingeflossen sind, können die externe Validität und damit die Umsetzbarkeit im Alltag angenommen werden. Es ist zu bedenken, dass zeitliche und personelle Ressourcen sowie organisationale Strukturen die Schnittstellenarbeit im Einzelfall beeinflussen können. Die Empfehlungen können an örtliche Gegebenheiten adaptiert werden.
Unbounded Predicate Inner Product Functional Encryption from Pairings
Authors: Dowerah Uddipana , Dutta Subhranil , Mitrokotsa Aikaterini , Mukherjee Sayantan , Pal Tapas 
Published: June 2023

AbstractPredicate inner product functional encryption (P-IPFE) is essentially attribute-based IPFE (AB-IPFE) which additionally hides attributes associated to ciphertexts. In a P-IPFE, a message $${\textbf {x}}$$
x
is encrypted under an attribute $${\textbf {w}}$$
w
and a secret key is generated for a pair $$({\textbf {y}}, {\textbf {v}})$$

(
y
,
v
)

such that recovery of $$\langle {{\textbf {x}}}, {{\textbf {y}}}\rangle $$

⟨
x
,
y
⟩

requires the vectors $${\textbf {w}}, {\textbf {v}}$$

w
,
v

to satisfy a linear relation. We call a P-IPFE unbounded if it can encrypt unbounded length attributes and message vectors. $$\bullet $$
∙
zero predicate IPFE. We construct the first unbounded zero predicate IPFE (UZP-IPFE) which recovers $$\langle {{\textbf {x}}}, {{\textbf {y}}}\rangle $$

⟨
x
,
y
⟩

if $$\langle {{\textbf {w}}}, {{\textbf {v}}}\rangle =0$$

⟨
w
,
v
⟩
=
0

. This construction is inspired by the unbounded IPFE of Tomida and Takashima (ASIACRYPT 2018) and the unbounded zero inner product encryption of Okamoto and Takashima (ASIACRYPT 2012). The UZP-IPFE stands secure against general attackers capable of decrypting the challenge ciphertext. Concretely, it provides full attribute-hiding security in the indistinguishability-based semi-adaptive model under the standard symmetric external Diffie–Hellman assumption. $$\bullet $$
∙
non-zero predicate IPFE. We present the first unbounded non-zero predicate IPFE (UNP-IPFE) that successfully recovers $$\langle {{\textbf {x}}}, {{\textbf {y}}}\rangle $$

⟨
x
,
y
⟩

if $$\langle {{\textbf {w}}}, {{\textbf {v}}}\rangle \ne 0$$

⟨
w
,
v
⟩
≠
0

. We generically transform an unbounded quadratic FE (UQFE) scheme to weak attribute-hiding UNP-IPFE in both public and secret key setting. Interestingly, our secret key simulation secure UNP-IPFE has succinct secret keys and is constructed from a novel succinct UQFE that we build in the random oracle model. We leave the problem of constructing a succinct public key UNP-IPFE or UQFE in the standard model as an important open problem.
Intersection theory on moduli of smooth complete intersections
Authors: Di Lorenzo Andrea 
Published: June 2023

AbstractWe provide a general method for computing rational Chow rings of moduli of smooth complete intersections. We specialize this result in different ways: to compute the integral Picard group of the associated stack; to obtain an explicit presentation of rational Chow rings of moduli of smooth complete intersections of codimension two; to prove old and new results on moduli of smooth curves of genus $$\le 5$$

≤
5

and polarized K3 surfaces of degree $$\le 8$$

≤
8

.