bluuebunny/crossref_metadata_2025_split huggingface dataset:
Snooping Job Related Organizational Stress of Selected Faculty Members in Higher Education Institutions
Authors: P. Dueñas Mary Joy 
Published: April 2023

This study was conducted to determine the organizational stress of selected faculty members in higher education institutions. Using descriptive research designs, the study involved 256 selected full time regular faculty members in selected private and public colleges and universities in Negros. The survey questionnaire consisted of two parts: the demographic profile of the respondents and the level of stress mechanisms taken form COPE instrument by Carver (2013). Statistical tools included frequency counts, percentage distribution, mean ratings and standard deviation. Most faculty members belonged to age bracket of 39–47 years and were considered as middle adults. These are faculty members who had been in the institution for 1– 8 years. The majority of them were male and married that are caught in the midst of all these responsibilities from work and family and most of them were instructors. Among the organizational stressors, nature of work obtained the highest mean score and interpreted as moderately stressed as experienced by faculty members. Relationship with supervisors ranked second with the mean score of 2.56 interpreted as moderately stressed; co-curricular activities had a mean score of 2.50 interpreted as moderately stressed. Furthermore, time spent in school obtained a mean score of 2.28 interpreted as slightly stressed; relationship with the students got a mean score of 2.26 interpreted as slightly stressed and relationship with peers, ranked lowest with a mean score of 1.80 interpreted as slightly stressed. Taken all together, the survey obtained a mean of 2.36, which is interpreted as slightly stress. Based on the results of the study, the following initiatives to mitigate the effect of stress are proper delegation of work assignment and effective stress management program with the support from school administration to make the faculty members feel that they are valued and taking care of.
SOCIAL MEDIA, ISLAMIC FINANCIAL LITERACY, AND ISLAMIC BANKING PRODUCT OWNERSHIP: A MODERATING MODEL
Authors: Lutfi Lutfi , Prihatiningrum Vita 
Published: April 2023

The role of social media and Islamic financial literacy is critical in influencing the consumer to have Islamic financial products. However, no studies on this topic have been conducted in Indonesia. The use of social media by a millennial is snowballing. This study examines the impact of social media, represented by the attractiveness of influencers and social media engagement, on the intention to own Sharia banking investment products among the millennial generation. This study also examines the role of Islamic financial literacy and income as independent and moderating variables. Data is collected using purposive sampling, followed by convenience sampling through a Google form questionnaire distributed to the social media users of Gen Z in the Surabaya agglomeration area. This study used 216 questionnaires and analyzed them using Partial Least Square - Structural Equation Model (PLS-SEM). The results show that influencer attractiveness, social media engagement, and Sharia financial literacy positively influence millennials' ownership intention of Islamic banking investment products. Islamic financial literacy weakens influencer attractiveness's impact on the ownership intention of Islamic banking investment products, while income does not moderate the relationship. Furthermore, social media engagement is most significant in determining product ownership intentions. The practical implication of the findings suggests the importance of Islamic banks to encourage more engagement of their social media users by providing useful information about bank products. This research provides a theoretical contribution to the theory of consumer behavior and social media that using social media is one of the most effective ways of influencing consumer purchasing decisions.
The Abolition of Sex/Gender Registration in the Age of Gender SelfDetermination: An Interdisciplinary, Queer, Feminist and Human Rights Analysis
Authors: Decoster Ariël , Cannoot Pieter 
Published: April 2023

It is commonly accepted that gender matters (whether cisgender, transgender/trans*, gender non-binary, genderfluid, gender queer, agender, or other) and many are raising awareness about the fact that gender always seems to matter. That gender matters, and always matters, does not necessarily mean, however, that gender needs to be authenticated or endorsed by the state.
In fact, based on a feminist and queer reading of human rights, this interdisciplinary article asserts that state-sponsored sex/gender assignment through the practice of sex/gender registration must halt. It argues that mandatory (binary) sex/gender registration disproportionately infringes the emerging right to gender identity autonomy and the right to the legal recognition thereof. Most often, our Western heterosexual cultural system of gender, which posits the existence of two oppositional and complementary gender identities, anchored in so-called natural and binary sex, goes hand in hand with material and discursive forms of violence and entails various forms of unequal power dynamics. Hegemonic in nature, the heterosexual cultural system of gender pervasively regulates many (if not every) aspects of all bodies’ lives and being, including by legal means. The law upholds and certifies that specific gender regime, inter alia, by assigning a sex to individuals at birth (through the registration of a claimed evident, objective, natural element to be found on or in the body by inspection). Policies of mandatory (binary) sex/genderregistration therefore constitute the cornerstone of the legalisation of the heterosexual cultural system of gender, which produces not only the conventional feminine and masculine gender identity (i.e. women and men) but also sex (i.e. females and males).
This article suggests that, as long as the law refuses to go beyond the compulsory male/female (or even male/female/other) framework, it will be complicit in upholding the undesired consequences of the heterosexual cultural system of gender, which affect all persons of whatever gender or physical features. Therefore, undoing remaining forms of global gender injustice, as well as respecting, protecting and fulfilling human rights relating to gender identity, requires the abolishment of sex/gender registration instead of expanding the available gender markers. Indeed, this article finds that current state practices do not pursue a legitimate aim, and even if they do, mandatory sex/gender registration does not pass the proportionality test that is required in the assessment of restrictions of fundamental rights. A human rights analysis of official sex/gender in the age of gender self-determination finds mandatory sex/gender registration to be a disproportionate measure and recommends that states change their current practices. Doing so would be beneficial to cisgender and trans* individuals alike.
The Journey To Legal Capability: Challenges for Public Law from Public Legal Education
Authors: Olatokun Abiodun Michael 
Published: April 2023

Citizens whose rights are infringed by a public authority are often unable to attain a court judgment to challenge those adverse decisions. The trite explanation is the most compelling; judicial review is a prohibitively expensive process. This high cost of litigation combined with the fees charged by public lawyers can make fighting for one’s legal rights inaccessible to those without independent means or publicly funded legal representation. There is no question that this is a complete explanation for many instances of unmet legal need, but this paper seeks to raise another important barrier to access to justice that is seldom discussed in the recent literature.
Legal capability is defined as the knowledge, skills and confidence required to participate in legal systems and to deal with one’s legal issues. It is thought to be improved through programmes of Public Legal Education (PLE). Whilst the author reiterates that legal education is no replacement for state-funded legal advice for the poor, PLE is a crucial tool in helping people to challenge public decision making.
The Challenge of Emerging Resistant Gram-Positive Pathogens in Hip and Knee Periprosthetic Joint Infections
Authors: Garvin Kevin L. , Kildow Beau J. , Hewlett Angela L. , Hartman Curtis W. , Fey Paul D. 
Published: April 2023

➤ An increase in resistant bacterial pathogens has occurred over the last 4 decades.➤ Careful patient selection and improving or correcting risk factors for periprosthetic joint infection (PJI) before elective surgical treatment are strongly recommended.➤ Appropriate microbiological methods, including those used to detect and grow Cutibacterium acnes, are recommended.➤ Antimicrobial agents used in the prevention or management of infection should be selected appropriately and the duration of therapy should be carefully considered in order to mitigate the risk of developing bacterial resistance.➤ Molecular methods including rapid polymerase chain reaction (PCR) diagnostics, 16S sequencing, and/or shotgun and/or targeted whole-genome sequencing are recommended in culture-negative cases of PJI.➤ Expert consultation with an infectious diseases specialist (if available) is recommended to assist with the appropriate antimicrobial management and monitoring of patients with PJI.
From we ask to iASK: a self-reflection strategy that enables students to connect assessment and employability
Authors: Spagnoli Dino , Kinash Shelley , Jorre De St Jorre Trina , Male Sally , Mouat Clare M , McDougall Kevin 
Published: April 2023

Most students acknowledge shared responsibility, with the university, for their employability development. Many academics use assessments as the main driver for motivating students to learn. At the intersection between employability, assessment and learning, the emergent research question is - what are the mechanisms by which course-based employability is fostered? Prior research reveals that although academics identified course-based assessment as the key employability mechanism, neither students nor employers registered this conceptualisation, and thus purpose of assessment. The aim of this research was to stimulate and communicate the direct connection between assessment and employability to students and interpret their response. Over 100 first-year students, across a metropolitan and regional Australian university, participated. Students were directed to use a simple reflective tool, dubbed iASK by the researchers, that probed employability elements of identity, Attributes, Skills, and Knowledge. The research revealed the resulting student view that regular course-based assessment can develop their employability skills in communication and independence, but not in critical thinking and global citizenship.
Improvement the expression and purification of Loa22: a lipoprotein with OmpA domain from pathogenic Leptospira serovars
Authors: Gharakhani Mehdi , Ghasemi Mohammad Faezi , Khaki Pejvak , Esmaelizad Majid , Tebianian Majid 
Published: April 2023

Abstract
Outer membrane proteins (OMPs) are the main surface antigens of the pathogenic Leptospires. One of the highly conserved outer membrane proteins expressed only by pathogenic Leptospires is Loa22. This study aims is to obtain the optimum conditions for high expression and purification of Loa22 recombinant (rLoa22) protein. Based on evidence of phylogenetic studies, complete coding sequence of loa22 gene was optimized based on codon usage chart and sub-cloned into a pET32a (+) expression vector. BL21 (pLysS) was used as expression host for transformation. The recombinant clones selected on ampicillin plates and subjected to PCR by using pET T7 primers and expression conditions optimized then by adjusting parameters such as culture media, induction time, temperature, and IPTG concentration. SDS-PAGE Analysis showed that the production of rLoa22 protein was at the highest level when post induction incubation, IPTG concentration, and duration of induction were 37ºC, 0.1 M and 5 h in 2xTY medium respectively. Due to the soluble nature of the protein, the purification of the rLoa22 protein under native conditions using Ni-NTA pull-down was optimum in one hour binding process at 37°C, five times washing process and elution buffer with a pH 7.4 and a 0.3 M imidazole concentration. Based on the results of this study, optimizing the expression and purification process for over production of rLoa22 protein resulted in the large quantity of pure recombinant antigen that forms the basis for future investigation on the design of rapid diagnostic tests and more effective subunit vaccine candidates for leptospirosis.
Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation
Authors: Carvalho Gabriela Corrêa , Marena Gabriel Davi , Nascimento André Luiz Carneiro Soares do , Camargo Bruna Almeida Furquim , Sábio Rafael Miguel , Lourenço Felipe Rebello , Santos Hélder A. , Chorilli Marlus 
Published: April 2023

Abstract
Lycopene (LYC), a carotenoid extracted mainly from tomatoes, has several biological properties, making its use desirable as a nutraceutical and pharmaceutical active ingredient. However, the use of LYC in therapy has limitations related to its solubility and stability. In this study, mesoporous silica nanoparticles (MSNs) are used to load and protect LYC from degradation. The exact amount of drug incorporated was determined by analytical techniques, such as high performance liquid chromatography (HPLC) and thermal analysis. For this we developed and validated an HPLC method for LYC quantification and evaluated the LYC impregnated in MSNs, followed by thermogravimetry analysis (TGA) technique analysis. Differential scanning calorimetry (DSC) was also used in order to confirm drug incorporation. Additionally, an in vitrorelease study was also carried out. The HPLC method was duly validated for the range of 26–125 µg/mL and proved to be suitable for LYC quantification. DSC measurements suggest an improvement in the stability of the impregnated drug, which was reinforced by the release assay. Overall, the developed method is suitable to test LYC-loaded porous materials to enable the use in therapeutic applications.
Flavopiridol suppresses cell proliferation and migration and induces apoptotic cell death by inhibiting oncogenic FOXM1 signaling in IDH-wild type and -mutant GBM cells
Authors: Güler Ahsen , Hamurcu Zuhal , Ulutabanca Halil , Cınar Venhar , Nurdinov Nursultan , Erdem Serife , Ozpolat Bulent 
Published: April 2023

Abstract
Glioblastoma multiforme (GBM) remains one of the most challenging solid cancers to treat due to its highly aggressive and drug resistant nature. Flavopiridol is synthetic flavone that was recently approved by the FDA for the treatment of acute myeloid leukemia. Flavopiridol exhibits antiproliferative activity in several solid cancer cells and currently evaluated in clinical trials in several solid and hematological cancers. In this study, we investigated the molecular mechanisms underlying antiproliferative effects of Flavopiridol in GBM cell lines with wild type and mutant IDH1 (encoding isocitrate dehydrogenase 1). We found that Flavopiridol inhibits proliferation, colony formation, migration, and induces apoptosis in IDH1-wild type and IDH-mutant cells through inhibition of FOXM1 oncogenic signaling. Furthermore, flavopiridol treatment also inhibits of NF-KB, mediators unfolded protein response (UPR) (GRP78, PERK, IRE1α) and DNA repair enzyme PARP, which have been shown, be potential therapeutic targets by downregulating FOXM1 in GBM cells.
Our findings suggest for the first time that flavopiridol suppresses proliferation, survival and migration and induces apoptosis in IDH1-wild type and mutant GBM cells by targeting FOXM1 oncogenic signaling which also regulates NF-KB, PARP, UPR responsein GBM cells. Flavopiridol may be a potential novel therapeutic strategy in the treatment of patients IDH1-wild type and mutant GBM.
Variability of toe pressures during haemodialysis: Comparison of people with and without diabetes; a pilot study
Authors: Carle Rachel , Tehan Peta , Stewart Sarah , Semple David , Pilmore Andrew , Carroll Matthew 
Published: April 2023

Abstract
Background Diabetes, end stage renal disease (ESRD), and peripheral arterial disease (PAD) are associated with a higher risk of diabetes-related lower limb amputation. Timely identification of PAD with toe systolic blood pressure (TSBP) and toe-brachial pressure index (TBPI) is critical in order to implement foot protection strategies to prevent foot complications in people with ESRD. There is limited evidence describing the effect of haemodialysis on TSBP and TBPI. This study aimed to determine the variability of TSBP and TBPI during haemodialysis in people with ESRD, and to determine whether any observed variability differed between people with and without diabetes.Methods TSBP and TBPI were taken before dialysis (T1), one hour into dialysis (T2) and in the last 15 minutes of dialysis (T3) during a single dialysis session. Linear mixed effects models were undertaken to determine the variability in TSBP and TBPI across the three time points and to determine whether this variability differed between people with and without diabetes.Results Thirty participants were recruited, including 17 (57%) with diabetes and 13 (43%) with no diabetes. A significant overall reduction in TSBP was observed across all participants (P < 0.001). There was a significant reduction in TSBP between T1 and T2 (P < 0.001) and between T1 and T3 (P < 0.001). There was no significant overall change in TBPI over time (P = 0.62). There was no significant overall difference in TSBP between people with diabetes and people with no diabetes (mean difference [95% CI]: -9.28 [-40.20, 21.64], P = 0.54). There was no significant overall difference in TBPI between people with diabetes and people with no diabetes (mean difference [95% CI]: -0.01 [-0.17, 03.16], P = 0.91).Conclusion TSBP and TBPI are an essential part of vascular assessment of the lower limb. TBPI remained stable and TSBP significantly reduced during dialysis. Given the frequency and duration of dialysis, clinicians taking toe pressures to screen for PAD should be aware of this reduction and consider how this may have an impact wound healing capacity and the development of foot related complications.
Zero To Hero? Reducing The Rate of Acute Kidney Injury in Transcatheter Aortic Valve Replacement: The Low Contrast Approach
Authors: Giraldo-Grueso Manuel , Bedi Ryan S. , Tafur-Soto Jose , Spindel Stephen M. 
Published: April 2023

Abstract
Background: Acute kidney injury is a complication after transcatheter aortic valve replacement (TAVR) that increases hospital stay, morbidity, and mortality; moreover, the amount of contrast has been linked to acute kidney injury. Reducing the contrast during TAVR is hypothesized to decrease acute kidney injury without compromising outcomes.
Methods: A single-institution retrospective analysis was performed on patients undergoing TAVR from 2017 to 2019. Patients with 20 mL or less of contrast were labeled as group I, and patients with more than 20mL of contrast were labeled as group II. Primary endpoints were 30-day mortality, acute kidney injury, and early aortic regurgitation.
Results: Between 2017 and 2019, 597 patients underwent TAVR, of which 594 met the inclusion and exclusion criteria. Four hundred twenty-nine (71%) patients were included in group I, and 165 (29%) were included in group II. Two hundred eight patients (51%) and 41 patients (24.6%) from group I and group II had chronic kidney disease stage III or IV. The mean contrast volume was 8.5mL (± 6) for group I and 33mL (± 16) for group II (p<0.001).Thirteen patients (3%) from group I had acute kidney injury; six (1.5%) required hemodialysis. In group II, nine (5.5%) patients had acute kidney injury (p=0.146); one required hemodialysis (p=0.435). Of all, 579 (97%) had less than moderate aortic regurgitation in the postoperative echocardiogram.
Conclusion: Low contrast TAVR is safe and effective and can reduce the incidence of acute kidney injury without affecting outcomes such as death, aortic regurgitation, and the need for a permanent pacemaker.
Profiling virulence genes in Palestinian strains of community- acquired methicillin-resistant Staphylococcus aureus, exposing those encoding exfoliative toxin
Authors: Azmi Kifaya , Qrei Walaa , Abdeen Ziad 
Published: April 2023

Abstract
The genes of Staphylococcus aureus encode several toxins causing or strongly suspected of causing specific diseases and adverse symptoms. The distribution of genes encoding superantigens and the gene profiles and genetic background of Palestinian strains of methicillin-resistant Staphylococcus aureus (MRSA) were determined. Strains separated into 12 clonal complexes (CCs) and 41 spa types, and possessed at least one of the studied enterotoxin genes: seo being most prevalent in 69.7% of the strains: followed by seh in 53.3% of the strains. Many (42.6%) of the strains possessed the genes for the classic staphylococcal enterotoxin (SE) sea, seb, sec, sed, and see, whereas 69.2% of the strains possessed the genes of the enterotoxin gene cluster, (egc), seg, seo, seh, sei, sem, seq, sej, sen, sek, sep, seu, sel, ser. Of the strains of S. aureus possessing the genes for Panton-Valentine leucocidin (PVL, n=105) among the strains of CA-MRSA, 16.2% (17/105) belonged to CC8-t008 and 18.1% (19/105) to CC80-t044. All four accessory gene regulator (agr) groups were present with agr group 1 being predominant in 44.1% of the strains. Forty-nine (25%) strains were multidrug resistant (MDR). This study provides information on the molecular markers of strains of S. aureus in clinical samples taken from Palestinian patients, including the characteristics of toxin genes possessed by Palestinian strains of CA-MRSA.
Evaluation of the influence of flame retardant additives on the creep behavior of ABS
Authors: Silva Thiago Moreira da , d’Almeida José Roberto Moraes , Cardoso Daniel Carlos Taissum 
Published: April 2023

Abstract
In this work, the effect of flame redardant additives on the creep behavior of ABS polymer was studied. Three ABS/flame redardant systems were compared with the bare ABS samples, namely: a commercial additive system based on bromine (Br-ABS), which served as a basis for comparison, and two systems recently developed, using tannic acid (TA) and ammonium polyphosphate (APP) bio-retardants. The results obtained in the creep tests showed that the commercial additive did not change the creep behavior in relation to ABS without additive. On the other hand, the results indicated that creep behavior was reduced when APP was incorporated into ABS and increased when TA was added. Experimental data from creep tests were used to evaluate the viscoelastic behavior of the four groups of materials. ABS had its behavior adequately represented by the Stretched Burgers model, as well as ABS with bromine-based additive, although with a low correlation coefficient. The model that best described the behavior of ABS with ammonium polyphosphate (APP) was also the modified Burgers model (Streched Burgers model). For ABS with tannic acid (TA), the model that best described the behavior was the standard linear solid.