bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-cavity pressure measurements for failure diagnosis in the injection moulding process and correlation with numerical simulation
Authors: Araújo Cátia , Pereira Diogo , Dias Diana , Marques Rita , Cruz Sílvia 
Published: February 2023

AbstractThe pressure profile analysis for monitoring and diagnosis processing failures during an injection moulding process, such as burn marks and short shots, is a useful instrument for process and part quality control and production with zero defects and greater efficiency. Therefore, this work aims to demonstrate the in-cavity pressure monitoring feasibility for failure diagnosis and injection moulding process optimization. The methodology used to analyse the obtained pressure variation is presented. The results were correlated to the typical cavity pressure profile, which enables the acquisition of information about the process and the moulding tool. This way, it was possible to determine the origin of the defects present in the injected parts, focusing not only on the velocity to pressure switchover but also on the initial part of the curve, related to the filling phase. Moreover, the obtained results and the studied processing conditions were correlated with the injection moulding process simulation.
Design and fabrication by selective laser melting of a LIDAR reflective unit using metal matrix composite material
Authors: Boschetto Alberto , Bottini Luana , Macera Luciano 
Published: February 2023

AbstractThe selective laser melting is an additive manufacturing technology able to directly fabricate full dense metal part from a virtual model. The geometrical complexity degree of freedom allows the implementation to several industrial applications such as the laser imaging detection and ranging systems. A key component of this system is the reflective unit produced with traditional technology (surface with ribs) with optimized geometry for lightweight, which must be further lightened while continuing to meet functional requirements. Aim of this work is to reach these goals by using an integrated product/process methodology which considers all the fabrication steps. A complete redesign allowed to exploit the additive manufacturing advantages of a metal matrix composite based on AA 2000 series combined with a high content of ceramic. The increased mechanical properties, such as the tensile strength of 484 MPa and Young modulus of 96GPa, combined with a lattice structure empowered the SLM capability. The component was validated via finite element method simulation focused on the most critical polishing operation. Results on static and dynamic analysis showed the 25% lightened mirror satisfies the requirements. The testing on the physical prototype confirmed the enhanced mechanical properties and the interferometric measurement proved the mirror functionality with a surface front error less than the required wavelength of 1550 nm. The work evidenced that polishing and the assembly configurations must be selected with particular care; otherwise, the final outcome is compromised for this SLMed component.
The Next Generation of Microbial Ecology and Its Importance in Environmental Sustainability
Authors: Lemke Michael , DeSalle Rob 
Published: February 2023

AbstractCollectively, we have been reviewers for microbial ecology, genetics and genomics studies that include environmental DNA (eDNA), microbiome studies, and whole bacterial genome biology forMicrobial Ecologyand other journals for about three decades. Here, we wish to point out trends and point to areas of study that readers, especially those moving into the next generation of microbial ecology research, might learn and consider. In this communication, we arenotsaying the work currently being accomplished in microbial ecology and restoration biology is inadequate. What we are saying is that a significant milestone in microbial ecology has been reached, and approaches that may have been overlooked or were unable to be completed before should be reconsidered in moving forward into a new more ecological era where restoration of the ecological trajectory of systems has become critical. It is our hope that this introduction, along with the papers that make up this special issue, will address the sense of immediacy and focus needed to move into the next generation of microbial ecology study.
How Controlled is the Expansion of VIATORR CX?
Authors: Dell Tatjana , Menne Matthias , Wagenpfeil Julia , Praktiknjo Michael , Jansen Christian , Isaak Alexander , Mesropyan Narine , Steinseifer Ulrich , Attenberger Ulrike , Luetkens Julian , Meyer Carsten , Kuetting Daniel 
Published: February 2023

AbstractPurposeTo investigate and compare the physical properties of the new generation Gore VIATORR-Controlled Expansion Endoprosthesis (VCX) to those of the predecessor VIATORR stent in an in vitro experimental setup.Materials and MethodsA total of 12 stents (8 VCX; 4 VIATORR; GORE, USA) were examined. Radial resistive force (RRF) and chronic outward force (COF) were assessed using a radial force testing machine (RX-650, Machine Solutions Inc., USA). To assess the radial forces of the VCX above 8 mm, balloon expansion was performed between cycles.ResultsAll VCX stents show an abrupt decrease in COF at an external diameter of 8.3 mm; RRF decreases likewise at an external diameter of 8.5 mm. The predecessor VIATORR stent without the “controlled expansion” feature shows linear radial force reduction until full expansion at a diameter of 10 mm.The physical properties of the VCX can be altered by balloon modulation. Point of COF (RRF) reduction shifts to 8.5 mm (8.6 mm), 8.6 mm (8.8 mm) and 9.3 mm (9.6 mm) following modulation with a 8 mm, 9 mm and 10 mm balloon.ConclusionsThe VCX shows an abrupt and disproportionate decrease in COF and RRF at an external diameter of 8.3 mm, thus passive expansion to its nominal diameter of 10 mm is not to be expected. By means of balloon dilatation the physical properties of the stent can be altered, enabling customized TIPS creation. The previous VIATORR stent shows continuous COF and RRF until total expansion.
Sequential claim games
Authors: Kong Qianqian , Peters Hans 
Published: February 2023

AbstractWe consider the estate division or bankruptcy problem and assume that players sequentially put claims on the estate. Each part of the estate is then divided proportionally with respect to the number of claims on it. We focus on myopic play: players first claim the hitherto least claimed parts, and on subgame perfect equilibria. Our main result is that myopic strategies constitute a subgame perfect equilibrium if punishments for deviators are included.
Resistive switching behavior in ZnO:Ca thin films deposited by a pulsed laser deposition technique
Authors: Mejri I. H. , Omri K. , Ghiloufi I. , Silva J. P. B. , Gomes M. J. M. , El Mir L. 
Published: February 2023

AbstractCalcium-doped ZnO (CZO) nanopowders were synthesized using the sol–gel method. The structural characteristics were investigated by X-ray diffraction (XRD) and the analysis reveals that our samples are crystalized in a wurtzite hexagonal structure. The morphological properties and the chemical composition of the nanoparticles were studied by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX). The obtained powders are stoichiometric with crystallites in a nanometric scale aggregated in micrometric particles. Then, pulsed laser deposition (PLD) technique was used to grow Ca-doped ZnO thin films with different doping concentrations (1, 3, and 5%), on p-type Si substrates. The Ca doping effect on the electrical properties of the CZO films was investigated by current–voltage characteristics. A resistive switching (RS) effect was observed in the ITO/ZnO:Ca/Au structures. The RS behavior is dependent on the Ca doping concentration. The charge transport mechanisms of the devices were studied. In the positive bias voltage region, the transport is dominated by Ohmic and space-charge limited conduction mechanisms under low and high electric fields, respectively.
Everything but the squeal: a guide for head and neck surgery training on the live porcine model
Authors: Alcalá Rueda Ignacio , Sánchez Barrueco Álvaro , Cenjor Español Carlos , Castaño Abel Bogoya , Villacampa Aubá José Miguel 
Published: February 2023

Abstract
Purpose
The porcine model has been demonstrated to be cost-effective for head and neck surgery training. There is no literature describing the porcine head and neck anatomy. The purpose of this study is to provide a porcine surgical guide for training head and neck residents.

Methods
Five head and neck dissections were performed under general anesthesia on the Large White pig model in the animal facilities of the University Hospital Fundación Jiménez. Sessions were photographed, and reference anatomical measurements were taken.

Results
The sternum–chin distance (x = 15.80 cm, σ = 0.44), chin–chin distance (x = 11.10 cm, σ = 2.30), prelaryngeal musculature length (x = 10.30 cm, σ = 1.92) and supraomohyoid triangle area (x = 7.07 cm2, σ = 3.91) were among the measurements obtained. The porcine head and neck anatomy was detailed.

Conclusions
Head and neck porcine anatomy was thoroughly described, with emphasis on the similarities with human anatomy. The porcine model is capable of simulating human anatomy for surgery training.
Mechanisms linking bariatric surgery to adipose tissue, glucose metabolism, fatty liver disease and gut microbiota
Authors: Latteri Saverio , Sofia Maria , Puleo Stefano , Di Vincenzo Angelica , Cinti Saverio , Castorina Sergio 
Published: February 2023

Abstract
Purpose
In the last 20 years, bariatric surgery has achieved an important role in translational and clinical research because of obesity comorbidities. Initially, a tool to lose weight, bariatric surgery now has been shown to be involved in several metabolic pathways.

Methods
We conducted a narrative review discussing the underlying mechanisms that could explain the impact of bariatric surgery and the relationship between obesity and adipose tissue, T2D, gut microbiota, and NAFLD.

Results
Bariatric surgery has an impact in the relation between obesity and type 2 diabetes, but in addition it induces the white-to-brown adipocyte trans-differentiation, by enhancing thermogenesis. Another issue is the connection of bariatric surgery with the gut microbiota and its role in the complex mechanism underlying weight gain.

Conclusion
Bariatric surgery modifies gut microbiota, and these modifications influence lipid metabolism, leading to improvement of non-alcoholic fatty liver disease.
Dissecting the inflammatory tumor microenvironment of esophageal adenocarcinoma: mast cells and natural killer cells are favorable prognostic factors and associated with less extensive disease
Authors: dos Santos Cunha Alyne Condurú , Simon Adrian Georg , Zander Thomas , Buettner Reinhard , Bruns Christiane Josephine , Schroeder Wolfgang , Gebauer Florian , Quaas Alexander 
Published: February 2023

Abstract
Purpose
Esophageal adenocarcinoma (EAC) remains a challenging and lethal cancer entity. A promising target for new therapeutic approaches, as demonstrated by the success of immune checkpoint inhibitors, are tumor-associated immune cells and the tumor microenvironment (TME). However, the understanding of the TME in esophageal cancer remains limited and requires further investigation.

Methods
Over 900 EAC samples were included, including patients treated with primary surgery and neoadjuvant (radio-)chemotherapy. The immune cell infiltrates of mast cells (MC), natural killer cells (NK cells), plasma cells (PC), and eosinophilic cells (EC) were assessed semi-quantitatively and correlated with histopathological parameters and overall survival (OS).

Results
A high presence of all four immune cell types significantly correlated with a less extensive tumor stage and a lower frequency of lymph node metastasis, and, in case of NK cells, with less distant metastasis. The presence of MC and NK cells was favorably associated with a prolonged OS in the total cohort (MC: p < 0.001; NK cells: p = 0.004) and patients without neoadjuvant treatment (MC: p < 0.001; NK cells: p = 0.01). NK cells were a favorable prognostic factor in the total cohort (p = 0.007) and in the treatment-naïve subgroup (p = 0.04). Additionally, MC were a favorable prognostic factor in patients with lymph node metastasis (p = 0.009).

Conclusion
Our results indicate a complex and important role of mast cells, NK cells, and the other assessed immune cells in the tumor microenvironment of EAC. Therefore, they are one further step to a better understanding of the immune cell environment and the potential therapeutic implications in this cancer entity.
AI-aided exploration of lunar arch forms under in-plane seismic loading
Authors: Maqdah Jad , Memarzadeh Milad , Kampas Georgios , Málaga-Chuquitaype Christian 
Published: February 2023

AbstractIncreasing computational power has led to the expansion of civil engineering research into using machine learning concepts for developing improved design strategies. These strategies are particularly useful for the design of extra-terrestrial habitats under uncertain environmental conditions. This paper focuses on building an unsupervised machine learning model (convolutional autoencoder) capable of detecting patterns in arch shapes and differentiating between their stress and displacement contours. Foremost, detailed discussions of the model’s architecture and input data are presented. The variation of arch shapes and contours between cluster centroids in the latent space is determined, proving the capability of optimisation by moving towards clusters with optimal contours. Finally, a regression model is built to investigate the relationship between the input geometric variables and the latent space representation. We prove that the autoencoder and regression models produce arch shapes with logical structural contours given a set of input geometric variables. The results presented in this paper provide essential tools for the development of an automated design strategy capable of finding optimal arch shapes for extra-terrestrial habitats.
The effect of surgical repair of hiatal hernia (HH) on pulmonary function: a systematic review and meta-analysis
Authors: Wang Y. , Lv Y. , Liu Y. , Xie C. 
Published: February 2023

Abstract
Purpose
Hiatal hernia is renowned for the symptom of reflux, and few physicians associate a hiatal hernia with pulmonary issues. It is widely acknowledged that a hiatal hernia can be treated with surgery. However, less is known about how the surgical procedure would benefit pulmonary function. Thus, the aim of this study was to determine whether surgical repair can improve pulmonary function in patients with hiatal hernias.

Methods
We registered the protocol on the PROSPERO (International Prospective Register of Systematic Reviews) platform (no. CRD42022369949). We searched the PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases for cohort studies that reported on the pulmonary function of patients with hiatal hernias. The quality of each cohort study was evaluated using the Newcastle–Ottawa scale (NOS). We then calculated mean differences (MDs) with 95% confidence intervals for these continuous outcomes. Each study’s consistency was appraised using the I2 statistic. The sensitivity analysis was performed using the trim-and-fill method. Publication bias was confirmed using the funnel plot visually and Egger regression test statistically.

Results
A total of 262 patients from 5 cohorts were included in the meta-analysis. The quality evaluation revealed that, of these 5 papers, 3 received 8 NOS stars out of 9 stars, 1 received 9, and the other received 7, meaning all included cohort studies were of high quality. The results showed that surgical repair for a hiatal hernia significantly improved forced expiratory volume in 1 s (FEV1; weighted mean difference [WMD]:0.200; 95% CI 0.047–0.353; I2 = 71.6%; P = 0.010), forced vital capacity (FVC; WMD: 0.242; 95% CI 0.161–0.323; I2 = 7.1%; P = 0.000), and total lung capacity (TLC; WMD: 0.223; 95% CI 0.098–0.348; I2 = 0.0%; P = 0.000) but had little effect on residual volume (RV; WMD: –0.028; 95% CI –0.096 to 0.039; I2 = 8.7%; P = 0.411) and the diffusing capacity carbon monoxide (DLCO; WMD: 0.234; 95% CI –0.486 to 0.953; I2 = 0.0%; P = 0.524).

Conclusion
For individuals with hiatal hernias, surgical repair is an efficient technique to improve respiratory function as measured by FEV1, FVC, and TLC.
A conserved mechanism determines the activity of two pivotal transcription factors that control epidermal cell differentiation in Arabidopsis thaliana
Authors: Nagata Kenji , Abe Mitsutomo 
Published: February 2023

AbstractThe surface of plants is covered by the epidermis, which protects the plant’s body from the external environment and mediates inter-cell layer signaling to regulate plant development. Therefore, the manifestation of epidermal traits at a precise location is a prerequisite for their normal growth and development. In Arabidopsis thaliana, class IV homeodomain-leucine zipper transcription factors PROTODERMAL FACTOR2 (PDF2) and ARABIDOPSIS THALIANA MERISTEM LAYER1 (ATML1) play redundant roles in epidermal cell differentiation. Nevertheless, several pieces of evidence suggest that the activity and/or function of PDF2 and ATML1 are regulated differently. The role of the steroidogenic acute regulatory protein-related lipid transfer (START) domain of ATML1 in restricting this protein’s activity has been demonstrated; however, whether this lipid-dependent mechanism regulates PDF2 expression is unknown. In this study, we demonstrated that the START domains of PDF2 and ATML1, regulate protein turnover in a position-dependent manner and affect the dimeric proteins. Our results show that a conserved mechanism provides the basis for the functional redundancy of PDF2 and ATML1 in epidermal cell differentiation and that an unidentified regulatory layer specific to PDF2 or ATML1 is responsible for the difference in the activity and/or function of PDF2 and ATML1.
Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia
Authors: Liu Qiuyu , Liu Nasi , van der Noord Vera , van der Stel Wanda , van de Water Bob , Danen Erik H. J. , Le Dévédec Sylvia E. 
Published: February 2023

AbstractHypoxia is linked to disease progression and poor prognosis in several cancers, including breast cancer. Cancer cells can encounter acute, chronic, and/or intermittent periods of oxygen deprivation and it is poorly understood how the different breast cancer subtypes respond to such hypoxia regimes. Here, we assessed the response of representative cell lines for the luminal and basal A subtype to acute (24 h) and chronic hypoxia (5 days). High throughput targeted transcriptomics analysis showed that HIF-related pathways are significantly activated in both subtypes. Indeed, HIF1⍺ nuclear accumulation and activation of the HIF1⍺ target gene CA9 were comparable. Based on the number of differentially expressed genes: (i) 5 days of exposure to hypoxia induced a more profound transcriptional reprogramming than 24 h, and (ii) basal A cells were less affected by acute and chronic hypoxia as compared to luminal cells. Hypoxia-regulated gene networks were identified of which hub genes were associated with worse survival in breast cancer patients. Notably, while chronic hypoxia altered the regulation of the cell cycle in both cell lines, it induced two distinct adaptation programs in these subtypes. Mainly genes controlling central carbon metabolism were affected in the luminal cells whereas genes controlling the cytoskeleton were affected in the basal A cells. In agreement, in response to chronic hypoxia, lactate secretion was more prominently increased in the luminal cell lines which were associated with the upregulation of the GAPDH glycolytic enzyme. This was not observed in the basal A cell lines. In contrast, basal A cells displayed enhanced cell migration associated with more F-actin stress fibers whereas luminal cells did not. Altogether, these data show distinct responses to acute and chronic hypoxia that differ considerably between luminal and basal A cells. This differential adaptation is expected to play a role in the progression of these different breast cancer subtypes.
Exploring the Efficacy of an Online Training Programme to Introduce Mental Health Recovery to Carers
Authors: Fox Joanna , Griffith Joannah , Smith Anne Marie 
Published: February 2023

AbstractFamily carers often support people with mental ill-health, however, there is a dearth of research on the importance of recovery to mental health carers. This article describes the delivery and qualitative evaluation of an online training programme on recovery to a group of eleven carers. The participants considered their understanding of the meaning of recovery, differentiating between its personal and clinical nature. They highlighted the importance of carer involvement in the service users’ professional support, alongside the need for carers to participate more widely in service development. Finally, the participants found the training useful in enabling them to recognise their own needs in a caring journey, particularly valuing its delivery by a service user and carer trainer. This study is limited by the small number of participants in this programme; however, this series of connected studies suggests its potential to be rolled out more widely, possibly embedded in Recovery Colleges.
A Realist Membership Account of Political Obligation
Authors: Szűcs Zoltán Gábor 
Published: February 2023

AbstractThe paper offers a realist account of political obligation. More precisely, it offers an account that belongs to the Williamsian liberal strain of contemporary realist theory (as opposed to a Geussian radical realist strain) and draws on and expands some ideas familiar from Bernard Williams’s oeuvre (thick/thin ethical concepts, political realism/moralism, a minimal normative threshold for distinctively political rule). Accordingly, the paper will claim that the fact of membership in a polity provides people with sufficient reason for complying with those political authority claims whose source is that particular polity. The paper will explain that membership in a polity is constituted not by communitarian identification (Horton), nationhood (Tamir), joined commitment/plural subjectivity (Gilbert), but by the fact that people are stably exposed to political authority claims associated with a particular polity which they find making sense as passing the minimal normative threshold for a distinctively political form of rule (as opposed to the rule of terror or sheer coercion). This political-ethical phenomenon is widely known as political obligation but the paper will argue that the label is in fact a misnomer because it does not refer to a generic obligation. The implications of this account are manifold but two seem especially important: first, the notion of political obligation makes sense even beyond the realm of moralist political theory and, second, realist political theory should pay more attention to the problem of compliance than it used to do.