bluuebunny/crossref_metadata_2025_split huggingface dataset:
COC use and ESR1 genetic variants associated with the risk of stroke
Authors: Huang Xiaoping , Yue Yuanping , Xu Zhenlin , Li Ying 
Published: August 2023

AbstractBackground Estrogen receptor α (ESR1) gene variation has been considered to be related to the development of cardiovascular disease. The aim of the present study is to determine the association ofESR1gene polymorphisms with risk of stroke and stroke subtypes in Chinese women, and further assess the gene-gene and gene-environment interactions betweenESR1gene and combined oral contraceptives (COC) on stroke risk. Methods A population-based case–control study was conducted. Three single nucleotide polymorphisms (SNPs) inESR1were genotyped in 453 first-ever stroke cases and 919 control subjects enrolled from our prospective female cohort, and information of contraceptive use was acquired by a face-to-face interview. Results AA genotype ofESR1rs4870056 compared with GG/GA genotypes was associated with a significantly decreased risk of hemorrhagic stroke (Recessive model:OR, 0.40; 95%CI, 0.20–0.82; qFDR = 0.036), while rs2228480 GA/AA genotype compared with GG genotype was found to be related to a slightly elevated risk of ischemic stroke (Dominant model:OR, 1.42; 95%CI, 1.02–1.97;P = 0.034). In addition, we identified significant gene-environment interactions between rs4870056 and COC use on stroke and ischemic stroke (Pinteraction=0.034 andPinteraction=0.012, respectively), but not on hemorrhagic stroke (Pinteraction=0.590). However, we found that rs4870056 GG/GA genotypes in combination with COC use jointly remarkably increased risk of hemorrhagic stroke (OR, 4.89; 95%CI, 1.82–13.13;P = 0.002). Conclusion Our findings suggested thatESR1rs4870056 polymorphism was significantly associated with hemorrhagic stroke in Chinese women, and the combined effect between GG/GA genotypes of rs4870056 and COC use could greatly increase the risk of hemorrhagic stroke.
What Type of Vehicles Do Households Own? A Joint Model for Vehicle Body, Vintage, Fuel, and Technology Types
Authors: Hossain Md. Shahadat , Fatmi Mahmudur Rahman , Enam Annesha 
Published: August 2023

Abstract
Households’ vehicle fleet composition has important policy implications in the area of transport-related energy consumption and emissions. With the recent development in different alternative fuel vehicles (AFVs) such as hybrid and electric vehicles and advanced technology features in the vehicle, the choice dimensions during vehicle purchase are not just limited to vehicle body and age. Households may also consider fuel and technology types. Therefore, this study focuses to investigate households’ vehicle type choices, specifically vehicle body, vintage, fuel, and technology types utilizing a survey conducted in British Columbia, Canada. A joint multinomial probit model has been developed that accommodates error correlations across alternatives among the different choice dimensions. The model results confirm significant correlations among the unobserved components. For instance, a significant positive correlation exists between alternative fuel vehicles and vehicles with advanced technology. The study also investigates the effects of households’ historical experiences such as historical vehicle fleet composition, and exposure to technology in daily life and vehicles. Historically owning AFVs and advanced technology in vehicles are found to have positive effects on the future preference for vehicles with advanced technology. Transit users and bikers show an inclination towards AFVs, which indicates a need for closer monitoring of the early adopters. The findings of the study provide insights towards targeted marketing to equitably promote the ownership of more sustainable, safer, and fuel-efficient vehicles among diverse age and income groups. Furthermore, the results inform land use and transportation policies to influence vehicle type choices for reducing fuel consumption and emissions.
Leveraging Distributed Storage Systems in Conjunction with Blockchain Solutions to Enhance Data Redundancy and Privacy in Organizations
Authors: STANESCU ANDREI BOGDAN , VAJAIALA CATALIN , COCIRLEA DRAGOS 
Published: August 2023

Abstract
In the current digital world, ensuring efficient storage capabilities and increased data privacy, as well as high data availability and redundancy, are critical key performance indicators for organizations striving for customer excellence. To achieve these, a modern two-layer technical architecture is proposed in this study. The core layer of the solution is an InterPlanetary File System (IPFS) Cluster that leverages the distributed storage concept, and the second is an Ethereum-based blockchain that leverages privacy and immutability mechanisms. Next, the two-layer architecture is implemented and deployed to enhance data protection, as well as optimize data storage and access for a mid-size organization. The results reveal the enhancement of IPFS to overcome its privacy concerns via role-based access and cryptographic techniques. Moreover, the benefits of utilizing IPFS for data redundancy, efficient storage, and transfer through its distributed nature were reported. Finally, the integration of the IPFS Cluster with the Ethereum-based blockchain, as well as the overall benefits, we described.
Research on automatic recognition of hand-drawn chemical molecular structures based on deep learning
Authors: Ouyang Hengjie , Liu Wei , Tao Jiajun , Luo Yanghong , Zhang Wanjia , Zhou Jiayu , Geng Shuqi , Zhang Chengpeng 
Published: August 2023

Abstract
Chemical molecule structures are important in academic communication because they allow for a more direct and convenient representation of chemical knowledge. Hand-drawn chemical molecular structures are a common task for chemistry students and researchers. If hand-drawn chemical molecular structures, such as SMILES codes, could be converted into machine-readable data forms. Computers would be able to process and analyze these chemical molecular structures, greatly increasing the efficiency of chemical research. Furthermore, with the advancement of information technology in education, automatic marking is becoming increasingly popular. Teachers will benefit greatly from having a machine recognize the chemical molecular structure and then determine whether they are drawn correctly. In this study, we will investigate the chemical molecular formulas consisting of three atoms C, H, O. Because there has been little research on hand-drawn chemical molecular structures, the first major task of this paper is to create a dataset. This paper proposes a synthetic image method for quickly generating synthetic images resembling hand-drawn chemical molecular structures and improving dataset acquisition efficiency. The final recognition accuracy of the hand-drawn chemical structure recognition model designed in this paper is 96.90% in terms of model selection. The model employs the EfficientNet + Transformer encoder-decoder architecture, which outperforms other encoder-decoder combinations.
Hydroxypropyl Methylcellulose Orodispersible Film Containing
Desloratadine for Geriatric Use: Formulation and Evaluation
Authors: Al-Oran Aya Yahya Fayez , Yenilmez Evrim 
Published: August 2023

Background:
Oral strip is very similar to thin strip of postage stamp in shape, size and thickness. The strip is designed to be placed on the tongue or any oral mucosal tissue which imme-diately gets wet and hydrated after being in contact with the saliva. Desloratadine is one of the bet-ter known second generation antihistamines that has been studied for being effective in relieving the allergic nasal and skin symptoms.

Objective:
The aim of this study is to develop desloratadine orodispersible film (ODF) with fast disintegration time and suitable mechanical strength to treat allergic symptoms in geriatric patients in order to increase compliance and convenience.

Methods:
Solvent casting method using hydroxypropyl methylcellulose (HPMC) as the film form-ing polymer was applied. Polyethylene glycol 400 (PEG 400) and glycerol (Gly) were used as the plasticizers and citric acid (CA) was used as saliva stimulating agent. The resultant films were evaluated for disintegration time, folding endurance, surface pH, weight variation, thickness, sur-face morphology using scanning electron microscopy, drug content, content uniformity, moisture loss, moisture uptake, and drug excipient compatibility using DSC and FT IR.

Results:
All the selected films started to disintegrate in less than 14 seconds. Selected optimum films exhibited good mechanical properties with a folding endurance value greater than 100. The uniformity in weight, thickness, and drug content in the selected films was obtained. Surface pH was within the normal range (6.4 6.8). A smooth surface of the films was obtained and drug
excipient compatibility was proved using DSC and FT IR. The dissolution test was done for opti-mum film formulations by simulating the oral cavity physiological conditions using the conven-tional dissolution test apparatus. More than 87% of the drug was released by the 4th minute.

Conclusion:
Orodispersible film of desloratadine was successfully prepared by solvent casting method in order to improve the disintegration/dissolution of the drug in oral cavity and hence better patient compliance and effective therapy.
Elimination of Herbicides after the Classification of Weeds Using Deep
Learning
Authors: Malik Indu , Singh Baghel Anurag 
Published: August 2023

Introduction:
Herbicides are chemicals that are used to destroy weeds. It is commonly used
in agriculture to kill undesired plants and increase crop yield, even though it has negative effects on
humans and the environment. Pesticides sprayed on crops must be decreased in the real world to protect
humans, animals, and birds from dangerous diseases such as cancer, eyes, and skin infection. Pesticides
are classified as herbicides. Deep learning is being used in this research to minimize chemical
compounds. Scientists seek to limit the amount of pesticide sprayed on crops to protect humans and the
environment from toxic exposure.

Background:
In this research, A neural network classifier is built using Convolutional Neural Network
(CNN), dropout, rectified linear activation unit (ReLU), the Root Mean Squared Propagation
(RMSprop) optimization technique, and stochastic gradient descent (SGD). The algorithms based on
CNN outperformed the others. This study uses generated dataset (unique dataset and processes it rowwise
through the Neural network) to train a categorized neural network, and the dataset was created
with the assistance of the agriculture professor.

Methods:
This study offers a method for classifying weed images and spraying herbicides solely on
weeds/unwanted plants rather than crops. The model should first be trained using the training dataset
before being tested using the testing datasets.

Results:
This model's training accuracy is 96%, while testing accuracy is 89%.

Conclusion:
This model reduced herbicide (it is a type of pesticide/chemical) spray over the crop
(foods, vegetables, sugarcane) to protect humans, animals, birds, and the environment from harmful
chemicals.
MANIFIESTO PARA LA ENFERMERÍA EN CHILE, UN LLAMADO A RESPONDER AL CONTEXTO DE CRISIS
Authors: Schilling Álvarez Marlene , Blanco Yantany Katerine , Castelblanco Sánchez Rocío , Concha Pérez Joselyn , Cruz Hernández Javiera , Grez Etcheverry Camila , Guajardo Sáez Bárbara , Hetz Flores Daniela , Ross Pincheira Tania , Campillay Campillay Maggie , Dubó Araya Pablo 
Published: August 2023

En un mundo cada vez más desigual y siempre en crisis, la profesión de Enfermería ha sido reconocida como clave para contribuir al cumplimiento de los Objetivos de Desarrollo Sostenible (ODS). Desde la perspectiva de las Determinantes Sociales de la Salud (DSS), la profesión enfrenta retos para hacer propuestas que respondan a la mejora de los cuidados de los grupos más vulnerables de la población. La siguiente reflexión intenta responder a la pregunta: ¿Cuáles son los desafíos sociopolíticos de enfermería en el actual contexto de crisis?. Esta se basa en la sistematización de trabajos realizados por una cohorte de enfermeras que cursan el Magíster en Enfermería de la Universidad de la Frontera. El manifiesto resultante propone y analiza nueve ejes temáticos que contribuyen a una visión positiva y esperanzadora del futuro de la profesión.
Efektivitas kombinasi Pistia stratiotes L. dan Salvinia molesta Mitchell dalam fitoremediasi air asam tambang batubara
Authors: Putri Deviana , Juswardi Juswardi 
Published: August 2023

Open pit mining is a mining system that is commonly applied to coal extraction activities. Environmental problems in coal mining activities are generally related to acid mine drainage (AMD). Efforts to overcome the impact of AMD can be done by phytoremediation in constructed wetlands (CW). Plants that have the potential for AMD phytoremediation include Pistia stratiotes L (water lettuce) and Salvinia molesta Mitchell (giant Salvinia) , so it is necessary to conduct research on the effectiveness of the combination of P. stratiotes and S. molesta to be developed on CW vegetation. The experimental design used was a completely randomized design (CRD), with 3 treatments using P. Stratiotes, S. Molesta, Combination of P. stratiotes and S. molesta each 9 replications. The results showed the effectiveness of phytoremediation using plant vegetation of P. stratiotes and S. molesta in increasing pH by 40.04% and reducing sulfate levels by 41.72%. The effectiveness of the combination of P. stratiotes and S. molesta in reducing levels of Mn and Fe were 101.36% and 93.49%, respectively. The decrease in TSS levels is better done by the combination of P. stratiotes and S. Molesta vegetation compared to P. stratiotes or S. Molesta vegetation alone, but the better growth rate occurred in S. molesta vegetation only.
Experimental Investigation of a Uniaxial Dielectric Elastomer Generator
Authors: Sikora Wojciech 
Published: August 2023

Abstract
The widespread use of battery-powered electronic devices creates the need to develop methods to extend their maximum operating time. This can be achieved by using ambient energy, which would otherwise be dissipated. The conversion of energy, usually mechanical energy, into electric energy takes place in energy harvesters. Energy harvester systems based on a dielectric elastomer (DE) are a relatively new field that is being constantly developed. Due to their features, dielectric elastomer generators (DEGs) may complement the currently dominant piezoelectric harvesters. The major feature of employing a hyperelastic material is that it allows relatively large displacements to be utilised for generating energy, which is impossible in the case of piezoceramics. This article presents a DEG designed to operate under uniaxial tensile loads and which has a multilayer structure, describes the general operating principles of a DEG, explains the construction and assembly process of the investigated design and shows the electric circuit necessary to properly direct current flow during the DEG operation. The experimental part consists of two series of tests based on a central composite design (CCD). The objective of the first part was to map a capacitance response surface of the DEG in the selected range of the cyclic mechanical load. The second part concerned the amount of generated energy for the specific load case as a function of operating voltages. The result of the work is the formulation of regression models that allow the characteristics of the presented DEG design to be identified.
THE LIGHT OF ACEH: IMPLEMENTASI KEBIJAKAN WISATA BERBASIS HALAL TOURISM DI KABUPATEN ACEH BARAT
Authors: Maulida Desi , Lestari Rachmatika , Safrida Safrida , Safrida Nila , Rahma Jumbratu 
Published: August 2023

Referring to Aceh Qanun Number 8 of 2013 concerning Tourism, the implementation of Aceh tourism is based on faith and Islam or known as halal tourism. Regency/city governments are given the authority to regulate the implementation and management of tourism in their respective regions, including West Aceh district. This study aims to analyze the implementation of halal tourism policies in West Aceh district. The research method used is qualitative with a case study approach. Data collection was carried out through interviews, observation and documentation studies. There were 9 informants in this study who came from the Tourism, Youth and Sports Office of West Aceh Regency, Tourism Awareness Groups, Tourists and West Aceh Tourism Ambassadors in 2021. The results of the study show that the implementation of the halal tourism policy has been running quite optimally. Communications is carried out by building coordination with related agencies. Resources are still relatively minimal, both Human Resources and Financial Resources. Furthermore, there has been an attitude from the government in pursuing halal tourism practices. This can be seen from the provision of halal tourism facilities and infrastructure and the sanctions given to violators (Disposition). Regarding the bureaucratic structure, the policy is still guided by the Aceh Qanun Number 8 of 2013 concerning TourismMerujuk pada Qanun Aceh Nomor 8 Tahun 2013 tentang Kepariwisataan, penyelenggaraan pariwisata Aceh didasarkan pada akidah dan Islam atau dikenal dengan istilah wisata halal. Pemerintah kabupaten/kota diberi kewenangan untuk mengatur penyelenggaraan dan pengelolaan kepariwisataan di daerahnya masing-masing termasuk kabupaten Aceh Barat. Penelitian ini bertujuan untuk menganalisis implementasi kebijakan wisata halal di kabupaten Aceh Barat. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan studi kasus. Pengumpulan data dilakukan melalui wawancara, observasi dan studi dokumentasi. Informan dalam penelitian ini berjumlah 9 orang yang berasal dari Dinas Pariwisata, Pemuda dan Olahraga Kabupaten Aceh Barat, Kelompok Sadar Wisata, Wisatawan dan Duta Wisata Aceh Barat tahun 2021. Hasil penelitian menunjukkan bahwa implementasi kebijakan wisata halal sudah berjalan dengan cukup maksimal. Communications dilakukan dengan membangun koordinasi bersama dinas-dinas terkait. Resources yang tersedia masih tergolong minim, baik itu Sumber Daya Manusia maupun Sumber Daya Finansial. Selanjutnya sudah adanya sikap dari pemerintah dalam mengupayakan praktik wisata halal. Hal tersebut terlihat dari penyediaan sarana dan prasarana wisata halal serta adanya sanksi yang diberikan kepada pelanggar (Disposition). Terkait dengan bureaucratic structure, kebijakan masih berpedoman pada Qanun Aceh Nomor 8 Tahun 2013 tentang Kepariwisataan.
ANIMISME DAN DINAMISME MASYARAKAT JAWA DALAM RUBRIK ALAMING LELEMBUT MAJALAH PANJEBAR SEMANGAT EDISI JANUARI-JUNI 2022
Authors: Widihastuti Rahma Ari 
Published: August 2023

Javanese people adhered to animism and dynamism long before they knew religion. Even after embracing religion, the practice of animism and dynamism is still firmly attached. The genre of stories that smell mystical, horror, and related to animism and dynamism is still very sustainable in mass media and is still in great demand. This study aims to identify the types of animism and dynamism beliefs that are still inherent in Javanese life, describe their meaning and function. The approach used is qualitative with descriptive methods, data collection techniques in the form of literature study techniques and data analysis techniques in the form of data reduction, data presentation, and conclusions. The source of the research data comes from 25 stories in the Alaming Lelembut rubric of Panjebar Semangat magazine, January-June 2022 edition. The results of the study were several types of animist beliefs: 1) spirits (genderuwo, wewe) waiting for old places; 2) haunted place waiters who get angry when harassed; 3) Sacrifice of wealth; 4) The spirits of the deceased are still wandering because there are unresolved things in the world. While dynamism is in the form of belief in sacred places that can bring wealth (ngalap berkah). The meaning and function of the belief is that there are still many mystical things that are believed and feared by the Javanese people, the existence of the belief to provide understanding and remind that there are other forces that coexist with humans. Javanese people agreed to continue to build this culture as a manifestation of the awareness of the need to remind themselves not to be greedy people and always remember that there are other entities that need to be respected in this world.
Keywords: animism, dynamism, alaming lelembut
CUMHURİYETİN İLANININ AKBABA GAZETESİNE YANSIMALARI
Authors: ÜÇÜNCÜ Uğur 
Published: August 2023

Akbaba, Türk Milli Mücadelesi yıllarından 1977’lere kadar dönemine ayna tutmayı başarabilmiş bir mizah gazetesidir. Gazetenin uzun yıllar varlığını sürdürebilmesinin en önemli sırrı yetenekli ve tecrübeli yayın kadrosu ile sahibi Yusuf Ziya Bey’in farklı dönemlerde siyasal erklerle iyi ilişkiler kurabilmesi ve onlardan destek bulmayı başarabilmesidir.
Akbaba, Türkiye’de cumhuriyetin ilanı sürecini yakından takip etmiştir. Başyazılar, köşe yazıları, kurgu diyalogları, mülakatlar ve şiirler ile mizahi perspektiften cumhuriyetin ilanı sürecini kamuoyuna taşımıştır. Akbaba, cumhuriyetin ilanını desteklemiştir ve cumhuriyetin o an için uygulanacak en iyi rejim olduğunu ve içselleştirilmesi gerektiği fikrini savunmuştur. Cumhuriyetin ilan usulüne karşı çıkanları başlangıçta önemsememişse de bir süre sonra eleştirmiştir. Cumhuriyeti hararetle destekleyen İttihatçıları ise samimi bulmamış, onları kendi çıkarları için cumhuriyeti kullanmaya çalışmakla suçlamıştır. Meşrutiyet denemesinin İttihatçıların keyfi uygulamalarıyla başarısız olduğunu sıklıkla vurgulayarak aynı hataların tekrar edilmemesi gerektiğine dikkat çekmiştir. Cumhuriyet’in en güçlü dayanağının Mustafa Kemal Paşa önderliğinde, vatan ve millet olduğu ve yeni rejimin güçlendirilerek, yaşatılarak geleceğe taşınması halinde Türkiye Cumhuriyeti’nin istikbalinden herkesin emin olabileceği düşüncesini savunmuştur.
Bu çalışmada öncelikle Akbaba gazetesinin kuruluşundan kapanışına kadarki gelişim evresi ortaya konmuştur. Ardından cumhuriyetin ilanının Akbaba’daki yansımaları dönemin genel ruhu etrafında incelenmiştir.
नेपालको मौलिक संस्कृति : भीमसेन
Authors: जोशी Joshi राजनलाल Rajanlal 
Published: August 2023

काठमाडौं उपत्यकालाई थातथलोको रूपमा लिंदै आएका नेवारहरू नेपाल भित्र र बाहिर विभिन्न स्थानमा बसोबास गर्दै आइरहेका छन् । धार्मिक, सांस्कृतिक रूपमा विविधता रहेको यो समुदायले आफू बसेको स्थानमा मौलिक संस्कृतिको विकास गर्ने गरेका छन् । यो समुदायले आफू जहाँ बसेपनि भीमसेनलाई आफ्नो इष्टदेवताको रूपमा पूज्ने गर्छन् । विशेषगरी व्यापारी वर्गले भीमसेनलाई पूजा आराधना नगरी दिनचर्या नै शुरु गर्दैनन् । फलस्वरूप यो समुदायले आफू जहाँ बसेपनि साना–ठुला भीमसेनको मन्दिर बनाउने गर्छन् । आस्था विश्वासका साथ पूजिंदै आएको भीमसेनलाई नेवार समुदायले मात्र व्यापारका देवताको रूपमा मात्र नरही आफ्नो पीडा कष्ट हटाउने देवताको रूपमा पनि लिने गरिन्छ । बलका देवताको रूपमा चिनिएका भीमसेनलाई कृषि र यौनका देवताको रूपमा समेत पूजिन्छ । फलस्वरूप नेवारहरूकोजीवनको अंगको रूपमा विकास गरेको भीमसेन पूजनलाई संस्कृतिको रूपमा नै विकास गरेको पाइन्छ ।
Penerapan Manajemen Network Router on Stick (RoS) Pada PT. Bank Rakyat Indonesia
Authors: Maulana Andry , Novarian Fahreza , Fauzi Ahmad 
Published: August 2023

kebutuhan jaringan internet pada generasi tiap zaman semakin meningkat disetiap tempat contohnya pada Kantor, Sekolah, Universitas dan lainnya. Namun seiring banyaknya kebutuhan muncul masalah yang dialami dalam penerapan jaringan komputer, beberapa permasalahan antara lain manajemen user yang terlalu banyak, tidak adanya konfigursi pembagian segmen, dan terbatasnya akses jaringan dibeberapa ruangan, hal ini dapat berakibat rentannya keamanan jaringan komputer. Penerapan interVLAN routing dengan metode Router On Stick (ROS) dapat memberikan solusi yang baik untuk penerapan segmen jaringan Metropolitan Area Nework (MAN) pada cakupan bank BRI (antar cabang). Hasil pengujian