bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient Preferences for Pain Control After Mohs Micrographic Surgery
Authors: Nugent Shannon T. , Veerabagu Surya A. , Madden Matthew , Yanes Arianna F. , Etzkorn Jeremy R. , Miller Christopher J. , Sobanko Joseph F. , Shin Thuzar M. , Higgins H. William , McMurray Stacy L. , Walker Joanna L. , Zhang Junqian , Giordano Cerrene N. 
Published: July 2023

ImportancePatient preferences for pain medications after Mohs micrographic surgery are important to understand and have not been fully studied.ObjectiveTo evaluate patient preferences for pain management with only over-the-counter medications (OTCs) or OTCs plus opioids after Mohs micrographic surgery given varying levels of theoretical pain and opioid addiction risk.Design, Setting, and ParticipantsThis prospective discrete choice experiment was conducted in a single academic medical center from August 2021 to April 2022 among patients undergoing Mohs surgery and their accompanying support persons (≥18 years). A prospective survey was administered to all participants using the Conjointly platform. Data were analyzed from May 2022 to February 2023.Main outcome and measureThe primary outcome was the pain level at which half of the respondents chose OTCs plus opioids equally to only OTCs for pain management. This pain threshold was determined for varying opioid addiction risk profiles (low, 0%; low-moderate, 2%; moderate-high, 6%; high, 12%) and measured via a discrete choice experiment and linear interpolation of associated parameters (pain levels and risk of addiction).ResultsOf the 295 respondents (mean [SD] age, 64.6 [13.1] years; 174 [59%] were female; race and ethnicity were not considered) who completed the discrete choice experiment, 101 (34%) stated that they would never consider opioids for pain management regardless of the pain level experienced, and 147 (50%) expressed concern regarding possible opioid addiction. Across all scenarios, 224 respondents (76%) preferred only OTCs vs OTCs plus opioids after Mohs surgery for pain control. When the theoretical risk of addiction was low (0%), half of the respondents expressed a preference for OTCs plus opioids given pain levels of 6.5 on a 10-point scale (90% CI, 5.7-7.5). At higher opioid addiction risk profiles (2%, 6%, 12%), an equal preference for OTCs plus opioids and only OTCs was not achieved. In these scenarios, patients favored only OTCs despite experiencing high levels of pain.Conclusion and relevanceThe findings of this prospective discrete choice experiment indicate that the perceived risk of opioid addiction affects the patient’s choice of pain medications after Mohs surgery. It is important to engage patients undergoing Mohs surgery in shared decision-making discussions to determine the optimal pain control plan for each individual. These findings may encourage future research on the risks associated with long-term opioid use after Mohs surgery.
Enhanced Anti‐inflammatory Capacity of the Conditioned Medium Derived from Periodontal Ligament Stem Cells Modified with an Iron‐Based Nanodrug
Authors: Wang Xinyue , Sun Liuxu , Qin Xuan , You Jiayi , Zhang Jing , Xia Yang 
Published: July 2023

AbstractCell‐free therapy using conditioned medium (CM) from mesenchymal stem cells takes full advantage of the bioactive factors secreted by the cells while avoiding disadvantages such as immune rejection and tumor formation due to cell transplantation. In this study, human periodontal ligament stem cells (PDLSCs) are modified with the superparamagnetic iron oxide nanoparticle (SPION)‐based nanodrug ferumoxytol (PDLSC‐SPION). Compared with PDLSCs, PDLSC‐SPION showed good cell viability and better osteogenic differentiation ability. Cell‐free CM is collected and the anti‐inflammatory capacity of PDLSC CM and PDLSC‐SPION CM is assessed by treatment of lipopolysaccharide‐stimulated macrophages and IL‐17‐stimulated human gingival fibroblasts. Both CMs inhibited the expression of proinflammatory cytokines in cells, and the therapeutic effect is more distinct for PDLSC‐SPION CM than PDLSC CM, which may be due to their different proteomic compositions. Therefore, modification of PDLSCs with ferumoxytol enhances the anti‐inflammatory capacity of its CM, making it more potentially useful for the treatment of inflammatory diseases such as periodontitis.
Modes and Mechanisms of Salivary Gland Epithelial Cell Death in Sjogren's Syndrome
Authors: Zhou Jiannan , Pathak Janak Lal , Liu Qianwen , Hu Shilin , Cao Tingting , Watanabe Nobumoto , Huo Yongliang , Li Jiang 
Published: July 2023

AbstractSjogren's syndrome is an autoimmune disease in middle and old‐aged women with a dry mucosal surface, which is caused by the dysfunction of secretory glands, such as the oral cavity, eyeballs, and pharynx. Pathologically, Sjogren's syndrome are characterized by lymphocyte infiltration into the exocrine glands and epithelial cell destruction caused by autoantibodies Ro/SSA and La/SSB. At present, the exact pathogenesis of Sjogren's syndrome is unclear. Evidence suggests epithelial cell death and the subsequent dysfunction of salivary glands as the main causes of xerostomia. This review summarizes the modes of salivary gland epithelial cell death and their role in Sjogren's syndrome progression. The molecular mechanisms involved in salivary gland epithelial cell death during Sjogren's syndrome as potential leads to treating the disease are also discussed.
Continuous‐Spectrum–Polarization Recombinant Optical Encryption with a Dielectric Metasurface
Authors: Wang Jiuxu , Yu Feilong , Chen Jin , Wang Jie , Chen Rongsheng , Zhao Zengyue , Chen Jian , Chen Xiaoshuang , Lu Wei , Li Guanhai 
Published: July 2023

AbstractThe Jones matrix, with eight degrees of freedom (DoFs), provides a general mathematical framework for the multifunctional design of metasurfaces. Theoretically, the maximum eight DoFs can be further extended in the spectrum dimension to endow unique encryption capabilities. However, the topology and intrinsic spectral responses of meta‐atoms constrains the continuous engineering of polarization evolution over wavelength dimension. In this work, a forward evolution strategy to quickly establish the mapping relationships between the solutions of the dispersion Jones matrix and the spectral responses of meta‐atoms is reported. Based on the eigenvector transformation method, arbitrary conjugate polarization channels over the continuous‐spectrum dimension are successfully reconstructed. As a proof‐of‐concept, a silicon metadevice is demonstrated for optical information encryption transmission. Remarkably, the arbitrary combination forms of polarization and wavelength dimension increase the information capacity (210), and the measured polarization contrasts of the conjugate polarization conversion are >94% in the entire wavelength range (3–4 µm). It is believed that the proposed approach will benefit secure optical and quantum information technologies.
Turing Patterns in Forced Open Two‐Side‐Fed‐Reactor
Authors: Grób László Mihály , Lagzi István , Szalai István 
Published: July 2023

AbstractThe mechanism suggested by Turing for reaction‐diffusion systems is widely used to explain pattern formation in biology and in many other areas. The persistence of patterns in altering environments is an important property in many natural cases. The experimental study of these phenomena can be done in chemical systems using appropriately designed reactors, e.g., in two‐side‐fed open gel reactors. This configuration allows for testing the effect of time‐periodic boundary conditions that generate periodic feeding of chemicals on the dynamics of Turing patterns. The numerical approach is based on a chemically realistic mechanism and a 2D description of the reactor that reproduces the feeding from the boundaries and the corresponding concentration gradients. Depending on the amplitude and the frequency of the forcing, two basic regimes are observed, spatiotemporal oscillations and pulsating spot pattern. In between them, a mixed‐mode pattern can also develop. Spot patterns can survive large amplitude forcing. The dynamics of the spot pulsation are analyzed in detail, considering the effect of the tanks and the chemical gradients that localize the patterns. These findings suggest that periodic feeding effectively controls pattern formation in chemical systems.
ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein
Authors: Jiang Yuying , Ma Chunmei , Hu Yingchao , Yang Yongbing , Ma Chanyuan , Wu Chunyan , Liu Lu , Wen Shuang , Moynagh Paul N. , Wang Bingwei , Yang Shuo 
Published: July 2023

AbstractThe intestinal epithelium is the fastest renewing tissue in mammals and its regenerative process must be tightly controlled to minimize the risk of dysfunction and tumorigenesis. The orderly expression and activation of Yes‐associated protein (YAP) are the key steps in driving intestinal regeneration and crucial for intestinal homeostasis. However, the regulatory mechanisms controlling this process remain largely unknown. Here, it is discovered that evolutionarily conserved signaling intermediate in Toll pathways (ECSIT), a multi‐functional protein, is enriched along the crypt–villus axis. Intestinal cell‐specific ablation of ECSIT results in the dysregulation of intestinal differentiation unexpectedly accompanied with enhanced YAP protein dependent on translation, thus transforming intestinal cells to early proliferative stem “‐like” cells and augmenting intestinal tumorigenesis. Loss of ECSIT leads to metabolic reprogramming in favor of amino acid–based metabolism, which results in demethylation of genes encoding the eukaryotic initiation factor 4F pathway and their increased expression that further promotes YAP translation initiation culminating in intestinal homeostasis imbalance and tumorigenesis. It is also shown that the expression of ECSIT is positively correlated with the survival of patients with colorectal cancer. Together, these results demonstrate the important role of ECSIT in regulating YAP protein translation to control intestinal homeostasis and tumorigenesis.
Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis
Authors: Li Yu , Zhang Yankang , Zhang Ting , Ping Xiaodan , Wang Dongmei , Chen Yanru , Yu Jian , Liu Caizhi , Liu Ziqi , Zheng Yuhan , Yang Yongfeng , Ruan Chengchao , Li Dali , Du Zhenyu , Wang Jiqiu , Xu Lingyan , Ma Xinran 
Published: July 2023

AbstractN6‐methyladenosine (m6A) modification has been implicated in the progression of obesity and metabolic diseases. However, its impact on beige fat biology is not well understood. Here, via m6A‐sequencing and RNA‐sequencing, this work reports that upon beige adipocytes activation, glycolytic genes undergo major events of m6A modification and transcriptional activation. Genetic ablation of m6A writer Mettl3 in fat tissues reveals that Mettl3 deficiency in mature beige adipocytes leads to suppressed glycolytic capability and thermogenesis, as well as reduced preadipocytes proliferation via glycolytic product lactate. In addition, specific modulation of Mettl3 in beige fat via AAV delivery demonstrates consistently Mettl3's role in glucose metabolism, thermogenesis, and beige fat hyperplasia. Mechanistically, Mettl3 and m6A reader Igf2bp2 control mRNA stability of key glycolytic genes in beige adipocytes. Overall, these findings highlight the significance of m6A on fat biology and systemic energy homeostasis.
Solvent‐derived Fluorinated Secondary Interphase for Reversible Zn‐graphite Dual‐ion Batteries
Authors: Tao Shiwei , Demir Baris , Baktash Ardeshir , Zhu Yutong , Xia Qingbing , Jiao Yalong , Zhao Yuying , Lin Tongen , Li Ming , Lyu Miaoqiang , Gentle Ian , Wang Lianzhou , Knibbe Ruth 
Published: July 2023

AbstractThe irreversibility of anion intercalation‐deintercalation is a fundamental issue in determining the cycling stability of a dual‐ion battery (DIB). In this work, we demonstrate that using a partially fluorinated carbonate solvent can drive a beneficial fluorinated secondary interphase layer formation. Such layer facilitates reversible anion (de−)intercalation processes by impeding solvent molecule co‐intercalation and the associated graphite exfoliation. The enhanced reversibility of anion transport contributes to the overall cycling stability for a Zn‐graphite DIB—a high Coulombic efficiency of 98.5 % after 800 cycles, with an attractive discharge capacity of 156 mAh g−1 and a mid‐point discharge voltage of ≈1.7 V (at 0.1 A g−1). In addition, the formed fluorinated secondary interphase suppresses the self‐discharge behavior, preserving 29 times of the capacity retention rate compared to the battery with a commonly used carbonate solvent, after standing for 24 hours. This work provides a simple and effective strategy for addressing the critical challenges in graphite‐based DIBs and contributes to fundamental understanding to help accelerate their practical application.
Cobalt‐Catalyzed Wagner–Meerwein Rearrangements with Concomitant Nucleophilic Hydrofluorination
Authors: Hoogesteger Reece H. , Murdoch Nicola , Cordes David B. , Johnston Craig P. 
Published: July 2023

AbstractWe report a cobalt‐catalyzed Wagner–Meerwein rearrangement of gem‐disubstituted allylarenes that generates fluoroalkane products with isolated yields up to 84 %. Modification of the counteranion of the N‐fluoropyridinium oxidant suggests the substrates undergo nucleophilic fluorination during the reaction. Subjecting the substrates to other known metal‐mediated hydrofluorination procedures did not lead to observable 1,2‐aryl migration. Thus, indicating the unique ability of these cobalt‐catalyzed conditions to generate a sufficiently reactive electrophilic intermediate capable of promoting this Wagner–Meerwein rearrangement.
Tetraazacoronene und ihre Dimere, Trimere und Tetramere
Authors: Eichelmann Robert , Ballmann Joachim , Gade Lutz H. 
Published: July 2023

AbstractTetraazacoronene wurden ausgehend von in bay‐Position funktionalisierten Tetraazaperylenen durch Zr‐vermittelte Zyklisierung und vierfache Suzuki–Miyaura Kreuzkupplung synthetisiert. Ein η4‐Cyclobutadien‐Zirconium(IV)‐Komplex wurde im Zr‐vermittelten Ansatz als Zwischenstufe zu Cyclobuten‐anellierten Derivaten isoliert. Verwendung von Bis(pinacolatoboryl)vinyltrimethylsilan als C2‐Baustein lieferte die Tetraazacoronen‐Zielverbindung zusammen mit ihrem kondensierten Azacoronen‐Dimer und den entsprechenden höheren Oligomeren. Die Serie verknüpfter Azacoronene zeigt hochaufgelöste UV/Vis Absorptionsbanden mit steigenden Extinktionskoeffizienten, die mit der π‐Erweiterung der aromatischen Kerne einhergeht und Emissionsquantenausbeuten von bis zu 80 % bei 659 nm.
Data‐driven approach for estimating longitudinal aerodynamic parameters using neural artificial bee colony fusion algorithm
Authors: Kumar Prashant , Sonkar Sarvesh Kumar , George Riya Catherine , Philip Deepu , Ghosh Ajoy Kanti 
Published: July 2023

AbstractAerodynamic parameter estimation involves modeling both force and moment coefficients along with the computation of stability and control derivatives from recorded flight data. Classical methods like output, filter, and equation errors apply extensively to this problem. Machine learning approaches like artificial neural networks (ANNs) provide an alternative to model‐based methods. This work presents a novel aerodynamic parameters estimation technique involving the fusion of two of the most popular machine learning methods. The process uses biologically inspired optimization techniques, the artificial bee colony (ABC) optimization with the widely used ANN for simulated data contaminated with the noise of varying intensity (5%, 10%) and for real aircraft while considering system and measurement uncertainty. Combining ABC and ANN results in a novel and promising method that can address the sensor noise challenges of system identification and parameter estimation. Comparing the proposed approach's results with other benchmark estimation techniques like Least Square and Filter Error Methods established its efficacy. Furthermore, the feasibility of the proposed hybrid method in extracting the stability and control variables from the stable aircraft kinematics is shown even with insufficient information in its data history.
Impact of ultrasound‐assisted extraction of polyphenols and caffeine from green tea leaves using high‐performance thin‐layer chromatography
Authors: Ashraf Gouhar Jahan , Das Priya , Sahu Ranabir , Nandi Gouranga , Paul Paramita , Dua Tarun Kumar 
Published: July 2023

AbstractTea is the most popular daily drink consumed globally, with a high concentration of caffeine and polyphenols. In this study, the effects of ultrasonic‐assisted extraction and quantification of caffeine and polyphenols from green tea were investigated and optimized using 23‐full factorial design and high‐performance thin‐layer chromatography. Three parameters were optimized to maximize the concentration of caffeine and polyphenols extracted using ultrasound: crude drug‐to‐solvent ratio (1:10–1:5), temperature (20–40°C), and ultrasonication time (10–30 min). The optimal conditions achieved from the model for tea extraction were as follows: crude drug‐to‐solvent ratio, 0.199 g/ml; temperature, 39.9°C; and time, 29.9 min; the extractive value was found to be 16.8%. Images from scanning electron microscopy showed that the matrix underwent a physical alteration and cell wall disintegration, which intensified and accelerated the extraction. This process might be simplified using sonication, which results in a higher extractive yield and a significant concentration of caffeine and polyphenols than the traditional approach, with a smaller quantity of solvent and faster analytical times. The result of high‐performance thin‐layer chromatography analysis proves a significant positive correlation between extractive value and caffeine and polyphenol concentrations.
The effect of task specific aids on students' performance and minimization of cognitive load in a virtual reality chemistry laboratory
Authors: Ali Numan , Ullah Sehat , Raees Muhammad 
Published: July 2023

AbstractDifferent cognitive aids (such as arrows, audio, etc.) are used in virtual laboratories for the enhancement of students' performance during their experimental tasks. However, excessive use of aids in virtual laboratories can lead to increased cognitive load, which affects task performance. In this article, we first conducted a subjective study with field experts to investigate about the practical implementation of our existing virtual chemistry laboratory. To consider the suggestions of the field experts, we propose task specific aids based virtual reality chemistry laboratory (TSA‐VRCL) to minimize students' cognitive load and enhance their performance. The task specific aids consist of an arrow, animation, and audio aids that are separately rendered with each step of the experimental tasks. During evaluations, eighty students performed the experiments in four different groups using four different experimental conditions. Evaluations revealed that the proposed TSA‐VRCL minimizes students' cognitive load and enhances their performance.
Catalytic Biomass Gasification in Supercritical Water and Product Gas Upgrading
Authors: Vadarlis Athanasios A. , Angeli Sofia D. , Lemonidou Angeliki A. , Boukis Nikolaos , Sauer Jörg 
Published: July 2023

AbstractThe gasification of biomass with supercritical water, also known as SCWG, is a sustainable method of hydrogen production. The process produces a mixture of hydrogen, carbon oxides, and hydrocarbons. Upgrading this mixture through steam or dry reforming of hydrocarbons to create synthesis gas and then extra hydrogen is a viable way to increase hydrogen production from biomass. This literature review discusses combining these two processes and recent experimental work on catalytic SCWG of biomass and its model compounds and steam/dry reforming of produced hydrocarbons. It focuses on catalysts used in these processes and their key criteria, such as activity, selectivity towards hydrogen and methane, and ability to inhibit carbon formation and deposition. A new criterion is proposed to evaluate catalyst performance in biomass SCWG and the need for further upgrading via reforming, based on the ratio of hydrogen bound in hydrocarbons to total hydrogen produced during SCWG. The review concludes that most catalysts used in biomass SCWG trap a large proportion of hydrogen in hydrocarbons, necessitating further processing of the product stream.
Favorable outcome of PML‐RARα short isoform and FLT3‐ITD mutation in a patient with several adverse prognostic markers: A case report
Authors: Bafail Mohammed A. , AlTahan Rahaf , Samman Manar A. , Tashkandi Suha A. , Motabi Ibraheem H. , Peer‐Zada Abdul Ali 
Published: July 2023

Key Clinical MessageComplete molecular remission in a “variant APL” patient with short isoform of PML‐RARα and FLT3‐ITD mutation was achieved in response to ATRA and ATO plus IDA instead of standard treatment protocol. The use of FLT3 inhibitor in APL induction management is implicated to prevent differentiation syndrome and coagulopathy experienced in in patients with FLT3‐ITD.AbstractFLT3‐ITD mutations are the most common activating mutations in FLT3 gene, occurring in about 12 to 38% of acute promyelocytic leukemia cases, and are mainly associated with high white blood cell counts and poor clinical outcomes. Here, we present a case of APL variant with adverse prognostic features who showed short isoform [bcr3] of PML‐RARα and FLT3‐ITD mutation at diagnosis. The patient received all‐trans retinoic acid (ATRA) and arsenic trioxide (ATO) plus idarubicin (IDA) instead of standard treatment protocol, and achieved a complete morphological, cytogenetic and molecular response. However, the patient experienced differentiation syndrome, and coagulopathy that was subsequently resolved by continuous oxygen therapy, dexamethasone, and enoxaparin. The use of FLT3 inhibitor in APL induction management is implicated to prevent differentiation syndrome and coagulopathy in patients with FLT3‐ITD mutation.
Shining a Light on the Advances, Challenges and Realisation of Utilising Photoredox Catalysis in Pharmaceutical Development
Authors: Callard‐Langdon Emily E. , Steven Alan , Kahan Rachel J. 
Published: July 2023

AbstractPhotoredox catalysis has advanced significantly over the last fifteen years, with improvements in technology facilitating implementation in both academic and industrial settings. Despite these advances, the uptake of photoredox catalysis in pharmaceutical development and manufacture has been slow, in part due to the challenge of developing a robust, transferable process. This perspective provides insight on the successes and difficulties encountered when applying photoredox catalysis to pharmaceutical development. It is hoped greater understanding of the challenges faced by the pharmaceutical industry will inform future research and encourage collaboration.