bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN ANTARA USIA DAN JENIS KELAMIN DENGAN KEJADIAN NEPHROLITHIASIS DI RUANG RAWAT INAP BEDAH RSUD DR. H. ABDUL MOELOEK PROVINSI LAMPUNG
Authors: Maulana Kiki , Purnanto Eko , Triswanti Nia , Prasetia Toni 
Published: June 2023

Abstrak : Hubungan Antara Usia Dan Jenis Kelamin Dengan KejadianNephrolithiasis Di Ruang Rawat Inap Bedah RSUD DR. H. Abdul MoeloekProvinsi Lampung. Nephrolithiasis (batu ginjal) adalah salah satu penyakit ginjal,dimana terdapatnya batu yang mengandung komponen kristal dan matriks organikyang menjadi penyebab terbanyak kelainan saluran kemih. Menurut Global Burdenof Disease (GDB) bersama Disease and Injury Incidence and Prevalence Collabolatorstahun 2015 mencatat terdapat 22,1 juta kasus nephrolithiasis dan mengakibatkansekitar 16.100 kematian. Penelitian ini bertujuan untuk mengetahui hubungan antarausia dan jenis kelamin dengan nephrolithiasis di Ruang Rawat Inap Bedah RSUD Dr.H. Abdul Moeloek Provinsi Lampung. Penelitian ini menggunakan penelitiankuantitatif dengan desain penelitian cross sectional yang dilaksanakan pada bulanOktober-November 2022 di Ruang Rawat Inap Bedah RSUD Dr. H. Abdul MoeloekProvinsi Lampung. Populasi dalam penelitian ini adalah seluruh pasien urolithiasis diRuang Rawat Inap Bedah RSUD Dr. H. Abdul Moeloek Provinsi Lampung tahun 2021-2022 sedangkan sampel yang diambil yaitu berjumlah 68 responden. Hasil penelitiandengan jumlah 68 responden berdasarkan usia menunjukan bahwa sebanyak 44orang (64,7%) terdiri dari kelompok usia 41-60 tahun, 12 orang (17,6%) terdiri darikelompok usia 21-40 tahun, dan untuk usia ≥ 61 tahun berjumlah 12 orang (17,6%). Sedangkan jika dilihat berdasarkan jenis kelamin didapatkan data paling tinggi terjadi pada jenis kelamin laki-laki yaitu sebanyak 44 orang (64,7%). Terdapat hubungan antara usia dan jenis kelamin dengan kejadian nephrolithiasis di ruang rawat inap bedah RSUD Dr. H. Abdoel Moeloek Provinsi Lampung.
ANALISIS TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN INFORMASI OBAT DI KLINIK UMMI HC KEDATON
Authors: Lestari Aulia Eka , Nofita Nofita , Ardiyansyah Ardiyansyah 
Published: June 2023

Abstrak:ANALISIS TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN INFORMASI OBAT DI KLINIK UMMI HC KEDATON. Kepuasan pasien dalam menerima Pelayan Informasi Obat (PIO) adalah hal yang sangat penting karena kepuasan pasien yang tinggi akan menggambarkan baik buruknya PIO yang diberika. Oleh sebab itu dilakukan Analisis Tingkat Kepuasan Pasien Terhadap Pelayanan Informasi Obat di Klinik Ummi HC Kedaton bertujuan untuk mengetahui tingkat kepuasan pasien terhadap Pelayanan Informasi Obat yang diberikan berdasarkan lima dimensi kepuasan yaitu Reliability (Keandalan), Assurance (Jaminan), Tangible (Penampilan), Emphaty (Empati), Responsivensess (Ketanggapan). Penelitian ini merupakan jenis penelitian deskriptif non ekperimental dengan model pendekatan Cross Sectional dengan metode yang paling terkenal untuk mengetahui kepuasan pelanggan yaitu Servqual (Service Quality). Penilaian terhadap kepuasan didapatkan dari hasil penyebaran kuesioner yang memuat 5 dimensi kepuasan. Responden dalam penelitian ini sebanyak 100 pasien yang mendapatkan obat dan menerima PIO. Hasil penelitian menunjukan bahwa tingkat kepuasan berdasarkan jenis kelamin perempuan (88,30%) dan laki-laki (83,43%), berdasarkan usia <18 tahun (96,21%), 18-25 tahun (92,46%), 26-45 tahun (89,96%), 46-65 tahun (91,48%), >65 tahun (81,81%). Berdasarkan pekerjaan swasta (90,24%), wiraswasta (89,81%), PNS (91,77%), dan lain-lain (93,01%). Berdasarkan pendidikan terakhir SMA (92,83%), D3 (88,18%), S1 (89,96%), dan lain-lain (100%). Analisis kuantitatif dengan Skala Likert menunjukan bahwa tingkat kepuasan berdasarkan dimensi Reliability (88,18%), dimensi Assurance (96,81%), dimensi Tangible (99,68%), dimensi Emphaty (97%), dan dimensi Responsiveness (73,75%). Sehingga persentase rata-rata tingkat kepuasan pasien terhadap Pelayanan Informasi Obat (PIO) di Klinik Ummi HC Kedaton secara keseluruhan sebesar (91,08%) dengan kategori sangat puas.
NYERI KEPALA SEKUNDER ET CAUSA RHINOSINUSITIS : LAPORAN KASUS
Authors: Fitriyani Fitriyani , Andhara Kevin 
Published: June 2023

Abstrak: Nyeri Kepala Sekunder ec Rhinosinusitis. Nyeri kepala adalah rasa nyeri atau rasa tidak mengenakkan pada daerah kepala dengan batas bawah dari dagu sampai kedaerah belakang kepala (area oksipital dan sebagian daerah tengkuk) Telah dilaporkan satu kasus di Rumah Sakit Pertamina Bintang Amin dengan keluhan nyeri kepala sekunder ec rhinosinusitis pada seorang perempuan berusia 49 tahun yang ditegakkan diagnosisnya berdasarkan anamnesis didapatkan nyeri kepala dari dahi hingga leher. pemeriksaan fisik nyeri ketuk maskila dan pemeriksaan penunjang CT scan didapatkan Sinusitis maksilaris ringan kiri dan Deviasi septum nasalis ke kanan, diberikan penanganan pemberian obat dengan paracetamol.
Gambaran Tingkat Pengetahuan Remaja Putri tentang Dampak Pernikahan Dini di SMA N 4 Sungai Raya Kabupaten Kubu Raya
Authors: Sofila Sofila , Murtilita Murtilita , Fujiana Fitri 
Published: June 2023

ABSTRACT The high incidence of early marriage is a problem that occurs in Indonesia today. With the high rate of early marriage, it will have an impact on various aspects both socially, economically, family, psychologically and especially on health, one of the main health problems that occurs is that it will experience reproductive health problems, especially for women. West Kalimantan has entered the third rank with the highest rate of early marriage in Indonesia has early marriage in Indonesia has increased, especially after the pandemic, namely since 2020. To describe the level of knowledge of young women about the impact of early marriage at SMA N 4 Sungai Raya. Quantitative research using descriptive research methods, totaling 133 respondents using proportionate stratified random technique. Data analysis used descriptive statistical analysis. The results of this study indicate that the majority of respondents at SMA N 4 Sungai Raya have sufficient knowledge, as many as 67 people (50,4%), 35 people with less knowledge (26,3%) and 31 people with good knowledge (23,3%). The level of knowledge of young women about the impact of early marriage at Sma n 4 Sungai Raya the most knowledge enough and the least knowledge well. Keywords: Impact of Early Marriage, Early Marriage, Knowledge ABSTRAK Tingginya tingkat kejadian pernikahan dini menjadi permasalahan yang terjadi di Indonesia saat ini. Dengan tingginya tingkat pernikahan dini ini akan berdampak pada berbagai macam aspek baik secara sosial, ekonomi, keluarga, psikologis dan terutama pada kesehatan, salah satu masalah kesehatan utama yang terjadi yaitu akan mengalami gangguan pada kesehatan reproduksi terutama pada wanita. Kalimantan Barat memasuki peringkat ke-3 dengan tingkat pernikahan dini tertinggi di Indonesia, dan pernikahan dini di Indonesia ini mengalami peningkatan terutama setelah terjadinya pandemi yaitu sejak tahun 2020. Mengetahui gambaran tingkat pengetahuan remaja putri tentang dampak pernikahan dini di SMA N 4 Sungai Raya. Penelitian kuantitatif dengan menggunakan metode penelitian deskriptif yang berjumlah 133 responden dengan menggunakan teknik proportionate stratified random. Analisa data menggunakan analisis statistik deskriptif. Hasil penelitian ini menunjukkan bahwa mayoritas responden SMA N 4 Sungai Raya berpengetahuan cukup sebanyak 67 orang (50,4%), berpengetahuan kurang 35 orang (26,3%) dan berpengetahuan baik 31 orang (23,3%). Tingkat pengetahuan remaja putri tentang dampak pernikahan dini di SMA N 4 Sungai Raya paling banyak berpengetahuan cukup dan paling sedikit yang berpengetahuan baik. Kata Kunci: Dampak Pernikahan Dini, Pernikahan Dini, Pengetahuan
Aleitamento materno em crianças portadoras de fenda labiopalatina: Revisão integrativa
Authors: Santos Hyasmym Kaiane Faesser , Moraes Suellen da Rocha Lage , Marques Ana Karolina de Oliveira 
Published: June 2023

Objetivo: é identificar na literatura quais fatores associados à adesão ao aleitamento materno exclusivo em lactantes de 0-6 meses de vida com fissura de lábio e/ou palato. Método: revisão integrativa. A busca foi realizada através da Biblioteca Virtual de Saúde, nas bases de Literatura Latina Americana e do Caribe em Ciências em Saúde (LILACS), Medical Literature Analysis and Retrieval System Online (MedLine) e Base de Dados em Enfermagem (BDENf). A seleção dos artigos foi realizada através da plataforma Rayyan no período de dezembro de 2022 à janeiro 2023. Resultados: Foi identificado através dos artigos, que após os genitores receberem as devidas orientações e o treinamento quanto ao uso de algumas técnicas como educação alimentar no pré-natal, perinatal e pós-natal, o uso de obturador palatino, placa de alimentação, protetor de mamilo, mamadeira especial e colher foi evidenciaram como fatores contribuintes para o sucesso da amamentação. Conclusão: poucos lactantes foram amamentados exclusivamente e por período conforme recomendado pela OMS. Identificado que o recebimento de orientações por profissionais de saúde no pré-natal, perinatal e pós-natal é de extrema importância e instigou de forma favorável, ou seja, o sucesso dessa prática está relacionado diretamente à complexidade da fissura, fator não modificável, mas, também, ao recebimento de orientações indicando ser este um espaço de intervenção a ser explorado. Comprovando também, que com as técnicas e equipamentos adequados é possível o sucesso da prática do aleitamento materno exclusivo em crianças portadoras de fenda lábio e/ou palato.
Lumbar and pelvis movement comparison between cross-court and long-line topspin forehand in table tennis: based on musculoskeletal model
Authors: He Yuqi , Liang Minjun , Fang Yufei , Fekete Gusztáv , Baker Julien S. , Gu Yaodong 
Published: June 2023

Introduction: Cross-court and the long-line topspin forehand is the common and basic stroke skill in table tennis. The purpose of this study was to investigate the differences in lumbar and pelvis movements between cross-court and long-line topspin forehand strokes in table tennis based on musculoskeletal demands using OpenSim.Materials and Methods: The eight-camera Vicon system and Kistler force platform were used to measure kinematics and kinetics in the lumbar and pelvis movement of sixteen participants (Weight: 69.89 ± 1.58 kg; Height: 1.73 ± 0.03 m; Age: 22.89 ± 2.03 years; BMI: 23.45 ± 0.69 kg/m2; Experience: 8.33 ± 0.71 years) during cross-court and long-line topspin forehand play. The data was imputed into OpenSim providing the establishment of the Giat2392 musculoskeletal model for simulation. One-dimensional statistical parametric mapping and independent samples t-test was performed in MATLAB and SPSS to analyze the kinematics and kinetics.Results: The results show that the range of motion, peak moment, and maximum angle of the lumbar and pelvis movement in cross-court play were significantly higher than in the long-line stroke play. The moment of long-line in the sagittal and frontal plane was significantly higher than cross-court play in the early stroke phase.Conclusion: The lumbar and pelvis embody greater weight transfer and greater energy production mechanisms when players performed cross-court compared to long-line topspin forehand. Beginners could enhance their motor control strategies in forehand topspin skills and master this skill more easily based on the results of this study.
Diffusible signal factor primes plant immunity against Xanthomonas campestris pv. campestris (Xcc) via JA signaling in Arabidopsis and Brassica oleracea
Authors: Zhao Qian , Liu Fang , Song Cong , Zhai Tingting , He Ziwei , Ma Limei , Zhao Xuemeng , Jia Zhenhua , Song Shuishan 
Published: June 2023

BackgroundMany Gram-negative bacteria use quorum sensing (QS) signal molecules to monitor their local population density and to coordinate their collective behaviors. The diffusible signal factor (DSF) family represents an intriguing type of QS signal to mediate intraspecies and interspecies communication. Recently, accumulating evidence demonstrates the role of DSF in mediating inter-kingdom communication between DSF-producing bacteria and plants. However, the regulatory mechanism of DSF during the Xanthomonas-plant interactions remain unclear.MethodsPlants were pretreated with different concentration of DSF and subsequent inoculated with pathogen Xanthomonas campestris pv. campestris (Xcc). Pathogenicity, phynotypic analysis, transcriptome combined with metabolome analysis, genetic analysis and gene expression analysis were used to evaluate the priming effects of DSF on plant disease resistance.ResultsWe found that the low concentration of DSF could prime plant immunity against Xcc in both Brassica oleracea and Arabidopsis thaliana. Pretreatment with DSF and subsequent pathogen invasion triggered an augmented burst of ROS by DCFH-DA and DAB staining. CAT application could attenuate the level of ROS induced by DSF. The expression of RBOHD and RBOHF were up-regulated and the activities of antioxidases POD increased after DSF treatment followed by Xcc inoculation. Transcriptome combined with metabolome analysis showed that plant hormone jasmonic acid (JA) signaling involved in DSF-primed resistance to Xcc in Arabidopsis. The expression of JA synthesis genes (AOC2, AOS, LOX2, OPR3 and JAR1), transportor gene (JAT1), regulator genes (JAZ1 and MYC2) and responsive genes (VSP2, PDF1.2 and Thi2.1) were up-regulated significantly by DSF upon Xcc challenge. The primed effects were not observed in JA relevant mutant coi1-1 and jar1-1.ConclusionThese results indicated that DSF-primed resistance against Xcc was dependent on the JA pathway. Our findings advanced the understanding of QS signal-mediated communication and provide a new strategy for the control of black rot in Brassica oleracea.
Obesity and PCOS radically alters the snRNA composition of follicular fluid extracellular vesicles
Authors: Wyse Brandon A. , Salehi Reza , Russell Stewart J. , Sangaralingam Mugundhine , Jahangiri Sahar , Tsang Benjamin K. , Librach Clifford L. 
Published: June 2023

IntroductionThe ovarian follicle consists of the oocyte, somatic cells, and follicular fluid (FF). Proper signalling between these compartments is required for optimal folliculogenesis. The association between polycystic ovarian syndrome (PCOS) and extracellular vesicular small non-coding RNAs (snRNAs) signatures in follicular fluid (FF) and how this relates to adiposity is unknown. The purpose of this study was to determine whether FF extracellular vesicle (FFEV)-derived snRNAs are differentially expressed (DE) between PCOS and non-PCOS subjects; and if these differences are vesicle-specific and/or adiposity-dependent.MethodsFF and granulosa cells (GC) were collected from 35 patients matched by demographic and stimulation parameters. FFEVs were isolated and snRNA libraries were constructed, sequenced, and analyzed.ResultsmiRNAs were the most abundant biotype present, with specific enrichment in exosomes (EX), whereas in GCs long non-coding RNAs were the most abundant biotype. In obese PCOS vs. lean PCOS, pathway analysis revealed target genes involved in cell survival and apoptosis, leukocyte differentiation and migration, JAK/STAT, and MAPK signalling. In obese PCOS FFEVs were selectively enriched (FFEVs vs. GCs) for miRNAs targeting p53 signalling, cell survival and apoptosis, FOXO, Hippo, TNF, and MAPK signalling.DiscussionWe provide comprehensive profiling of snRNAs in FFEVs and GCs of PCOS and non-PCOS patients, highlighting the effect of adiposity on these findings. We hypothesize that the selective packaging and release of miRNAs specifically targeting anti-apoptotic genes into the FF may be an attempt by the follicle to reduce the apoptotic pressure of the GCs and stave off premature apoptosis of the follicle observed in PCOS.
Assessing the impact of deficit irrigation strategies on agronomic and productive parameters of Menara olive cultivar: implications for operational water management
Authors: Ibba Khaoula , Kassout Jalal , Boselli Vladimiro , Er-Raki Salah , Oulbi Sara , Mansouri Loubna El , Bouizgaren Abdelaziz , Sikaoui Lhassane , Hadria Rachid 
Published: June 2023

The olive tree is an iconic tree in the Mediterranean region, traditionally cultivated under rainfed conditions; however, olive cultivars are also found outside the Mediterranean region and are widely used for oil and olive production. However, with the increasing aridity and global changes, olive agroecosystems are facing sustainability challenges. This study aims to evaluate the effect of two deficit irrigation strategies on the agronomic and productive parameters of the Menara, olive cultivar as a tool for operational irrigation water management. For this purpose, an experiment was conducted on an olive orchard for two consecutive years (2021 and 2022), comparing four regulated deficit irrigation (RDI) treatments and two sustained deficit irrigation (SDI) treatments, with fully irrigated trees. The results showed that moderate and controlled water stress under RDI did not significantly affect the yield of the Menara olive cultivar. In addition, by reducing plant water requirement by 20% during sensitive periods and by 40% during normal periods, under RDI, it is possible to save between 25% and 30% of irrigation water and to increase water productivity by 5%–20% with a slight decrease in fruit yield ranging between 10% and 15%. However, the trees subjected to the sustained deficit irrigation strategy exhibited a reduced capacity for shoot growth compared to those under RDI and fully irrigated conditions. Our findings showed that water deprivation during sensitive periods reduced phenological traits and slowed down shoot growth. Furthermore, the water status of the trees was reflected in fruit volume, as a decrease in water supply resulted in a corresponding reduction in fruit volume. Although the study provides important insights into water management strategies for olive cultivation, the short observation period does not allow for long-term plant adaptation evaluation and productivity beyond 2 years. Therefore, it is recommended that future studies extend the observation period to better understand plant adaptation to irrigation regimes.
Assessing uncertainty in genomic offset forecasts from landscape genomic models (and implications for restoration and assisted migration)
Authors: Lachmuth Susanne , Capblancq Thibaut , Keller Stephen R. , Fitzpatrick Matthew C. 
Published: June 2023

IntroductionEcological genomic models are increasingly used to guide climate-conscious restoration and conservation practices in the light of accelerating environmental change. Genomic offsets that quantify the disruption of existing genotype–environment associations under environmental change are a promising model-based tool to inform such measures. With recent advances, potential applications of genomic offset predictions include but are not restricted to: (1) assessing in situ climate risks, (2) mapping future habitat suitability while accounting for local adaptations, or (3) selecting donor populations and recipient areas that maximize genomic diversity and minimize maladaptation to future environments in assisted migration planning. As for any model-based approach, it is crucial to understand how arbitrary decisions made during the modeling process affect predictions and induce uncertainty.MethodsHere, we present a sensitivity analysis of how various modeling components influence forecasts of genomic offset-based metrics, using red spruce (Picea rubens), a cool-temperate tree species endemic to eastern North America, as a case study. We assess the effects of genomic marker set, climatic predictor set, climate change scenario, and “not-to-exceed” offset threshold and evaluate how uncertainty in predictions varies across space.ResultsClimate change scenario induced by far the largest uncertainty to our forecasts; however, the choice of predictor set was also important in regions of the Southern and Central Appalachians that are of high relevance for conservation and restoration efforts. While much effort is often expended in identifying candidate loci, we found that genomic marker set was of minor importance. The choice of a maximum offset threshold to limit transfers between potential donor and recipient locations in assisted migration programs has mostly affected the magnitude rather than geographic variation in our predictions.DiscussionOverall, our model forecasts suggest high climate change risks across the entire distributional range of red spruce and strongly underscore the potential for assisted migration to help ameliorate these risks. In that regard, populations in the Southern and Central Appalachians as well as along the US and Canadian east coast seem the best candidates for both in situ conservation and relocation.
Major depressive disorder plays a vital role in the pathway from gastroesophageal reflux disease to chronic obstructive pulmonary disease: a Mendelian randomization study
Authors: Zou Menglong , Zhang Wei , Shen Lele , Xu Yin , Zhu Ying 
Published: June 2023

Background: Observational studies have shown a bidirectional association between chronic obstructive pulmonary disease (COPD) and gastroesophageal reflux disease (GERD), but it is not clear whether this association is causal. In our previous study, we found that depression was a hot topic of research in the association between COPD and GERD. Is major depressive disorder (MDD) a mediator of the association between COPD and GERD? Here, we evaluated the causal association between COPD, MDD, and GERD using Mendelian randomization (MR) study.Methods: Based on the FinnGen, United Kingdom Biobank, and Psychiatric Genomics Consortium (PGC) databases, we obtained genome-wide association study (GWAS) summary statistics for the three phenotypes from 315,123 European participants (22,867 GERD cases and 292,256 controls), 462,933 European participants (1,605 COPD cases and 461,328 controls), and 173,005 European participants (59,851 MDD cases and 113,154 controls), respectively. To obtain more instrumental variables to reduce bias, we extracted relevant single-nucleotide polymorphisms (SNPs) for the three phenotypes from published meta-analysis studies. Bidirectional MR and expression quantitative trait loci (eQTL)-MR were performed using the inverse variance weighting method to assess the causal association between GERD, MDD, and COPD.Results: There was no evidence of a causal effect between GERD and COPD in the bidirectional MR analysis [forward MR for GERD on COPD: odds ratios (OR) = 1.001, p = 0.270; reverse MR for COPD on GERD: OR = 1.021, p = 0.303]. The causal effect between GERD and MDD appeared to be bidirectional (forward MR for GERD on MDD: OR = 1.309, p = 0.006; reverse MR for MDD on GERD: OR = 1.530, p &lt; 0.001), while the causal effect between MDD and COPD was unidirectional (forward MR for MDD on COPD: OR = 1.004, p &lt; 0.001; reverse MR for COPD on MDD: OR = 1.002, p = 0.925). MDD mediated the effect of GERD on COPD in a unidirectional manner (OR = 1.001). The results of the eQTL-MR were consistent with those of the bidirectional MR.Conclusion: MDD appears to play a vital role in the effect of GERD on COPD. However, we have no evidence of a direct causal association between GERD and COPD. There is a bidirectional causal association between MDD and GERD, which may accelerate the progression from GERD to COPD.