bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Storm Size on Sea Surface Cooling and Tropical Cyclone Intensification in the Western North Pacific
Authors: Liu Yuhao , Guan Shoude , Lin I.-I. , Mei Wei , Jin Fei-Fei , Huang Mengya , Zhang Yihan , Zhao Wei , Tian Jiwei 
Published: August 2023

Abstract
The effect of tropical cyclone (TC) size on TC-induced sea surface temperature (SST) cooling and subsequent TC intensification is an intriguing issue without much exploration. Via compositing satellite-observed SST over the western North Pacific during 2004–19, this study systematically examined the effect of storm size on the magnitude, spatial extension, and temporal evolution of TC-induced SST anomalies (SSTA). Consequential influence on TC intensification is also explored. Among the various TC wind radii, SSTA are found to be most sensitive to the 34-kt wind radius (R34) (1 kt ≈ 0.51 m s−1). Generally, large TCs generate stronger and more widespread SSTA than small TCs (for category 1–2 TCs, R34: ∼270 vs 160 km; SSTA: −1.7° vs −0.9°C). Despite the same effect on prolonging residence time of TC winds, the effect of doubling R34 on SSTA is more profound than halving translation speed, due to more wind energy input into the upper ocean. Also differing from translation speed, storm size has a rather modest effect on the rightward shift and timing of maximum cooling. This study further demonstrates that storm size regulates TC intensification through an oceanic pathway: large TCs tend to induce stronger SST cooling and are exposed to the cooling for a longer time, both of which reduce the ocean’s enthalpy supply and thereby diminish TC intensification. For larger TCs experiencing stronger SST cooling, the probability of rapid intensification is half of smaller TCs. The presented results suggest that accurately specifying storm size should lead to improved cooling effect estimation and TC intensity prediction.

Significance Statement
Storm size has long been speculated to play a crucial role in modulating the TC self-induced sea surface temperature (SST) cooling and thus potentially influence TC intensification through ocean negative feedback. Nevertheless, systematic analysis is lacking. Here we show that larger TCs tend to generate stronger SST cooling and have longer exposure to the cooling effect, both of which enhance the strength of the negative feedback. Consequently, larger TCs undergo weaker intensification and are less likely to experience rapid intensification than smaller TCs. These results demonstrate that storm size can influence TC intensification not only from the atmospheric pathway, but also via the oceanic pathway. Accurate characterization of this oceanic pathway in coupled models is important to accurately forecast TC intensity.
Hypothermic rescue by veno-arterial extracorporeal membrane oxygenation: A case report
Authors: Chen Hao , Yuan Wei , Sun Xiangyou , Sun Yutian , Zhang Jing , Wu Haibo 
Published: August 2023

Introduction Severe hypothermia is a life-threatening condition that often causes hemodynamic instability or cardiac arrest and carries a high risk of mortality. The use of VA-ECMO in this indication has greatly improved the prognosis of patients. Case report We describe an incredible case involving the complete recovery of a 47-year-old man placed on VA-ECMO for cardiogenic shock and protracted ventricular fibrillation caused by hypothermia. The patient was discharged home in 20 days with no neurologic sequelae. Clinical discussion Extracorporeal life support (ECLS) with cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO) has been recommended as the gold standard for the treatment of severe hypothermia due to its rapid availability and the possibility of prolonged support. Our case demonstrates the effectiveness of ECMO in treating patients with hypothermic cardiogenic shock. At the same time, nutritional support and rehabilitation therapy play an integral role in the whole treatment process. Therefore, it is recommended that such patients be managed by an experienced cardiac team that can evaluate the patient’s condition in multiple aspects. Conclusion ECMO may be an effective treatment for hypothermia-induced cardiogenic shock, but further research is needed on the effectiveness of this method of treatment.
Changes of regional cerebral blood flow after repeated transcranial direct current stimulation in healthy participants: a pilot study
Authors: Jeong Hyeonseok , Song In-Uk , Chung Yong-An , Kim Doyu , Na Seunghee , Lee Sang Hoon 
Published: August 2023

Background Transcranial direct current stimulation (tDCS) can potentially enhance brain function and cognition in healthy individuals as well as in patients with cognitive impairment. However, neural correlates of repeated tDCS remain relatively unexplored in a healthy population. Purpose To assess the effects of repeated tDCS on regional cerebral blood flow (rCBF) in healthy volunteers in a pilot investigation. Material and Methods Five healthy adults received bifrontal tDCS to the dorsolateral prefrontal cortex (F3–F4 montage, 1 mA intensity, 30 minutes/session, five sessions/week) over four weeks. All participants underwent brain single-photon emission computed tomography (SPECT) scans at baseline and one week after the last tDCS session. Changes in rCBF were examined using Statistical Parametric Mapping. Results Resting rCBF was significantly improved in the right superior frontal gyrus at the follow-up ( P < 0.001). Adverse events were not reported and the stimulation was well-tolerated. Conclusion Repeated tDCS may be effective for enhancing brain function in healthy participants. Larger sham-controlled studies should be performed to confirm our preliminary findings.
Pin-assisted retraction technique in unilateral biportal endoscopic discectomy: a retrospective cohort study
Authors: Jiang Xiaozhou 
Published: August 2023

Objective Unilateral biportal endoscopic (UBE) discectomy is a reliable endoscopic technique in the treatment of lumbar disc herniation. However, UBE discectomy involves a single-handed manipulation, which may compromise the utility of the procedure. The present study was performed to examine the efficacy and safety of a novel pin-assisted retraction technique. Methods This single-center retrospective cohort study involved 57 consecutive patients who underwent UBE lumbar discectomy from July 2021 to May 2022. The patients were randomly divided into the pin-assisted UBE discectomy group (P-UBE group) and the traditional UBE discectomy group (T-UBE group). The patients’ perioperative data, clinical outcomes, and radiologic outcomes were collected and compared between the two groups. Results The operative time, intraoperative blood loss, endoscopic irrigation volume, and overall complication rate were significantly lower in the P-UBE group than in the T-UBE group. There were no significant differences in the clinical outcome data between the two groups. Conclusion P-UBE discectomy may have superior safety and efficacy over the traditional technique, and it has the potential to serve as an optional method in UBE lumbar surgery.
Association with controlling nutritional status score and disease activity of ulcerative colitis
Authors: Lian Ziyu , Hu Jingyi , Cheng Cheng , Liu Yajun , Zhu Lei , Shen Hong 
Published: August 2023

Objective To explore the association between the controlling nutritional status (CONUT) score and disease activity in patients with ulcerative colitis (UC). Methods This retrospective study enrolled patients with UC. Demographic, clinical and laboratory data were collected and compared. The CONUT score was obtained for each patient. The association between the CONUT score and laboratory parameters was analysed and the ability of the score to assess disease activity was evaluated. Results A total of 182 patients with UC were enrolled. Patients with active disease showed significantly increased inflammatory biomarkers and decreased nutritional biomarkers compared with patients in remission. Malnourished individuals had significantly elevated inflammatory biomarkers and significantly reduced haemoglobin, prealbumin and retinol-binding protein. The CONUT score was inversely correlated with haemoglobin, prealbumin, retinol-binding protein and was positively correlated with faecal calprotectin, C-reactive protein, erythrocyte sedimentation rate, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. The area under the receiver operating characteristic curve was 0.655 (95% confidence interval, 0.557–0.752). The optimal cut-off value was 1.5 points, with a sensitivity of 75.7% and a specificity of 50.0%. Conclusion The CONUT score may evaluate the inflammatory response and nutritional status of UC patients, so it could be a potential biomarker to assess disease activity in UC.
Dynamics of cerebrospinal fluid pressure alterations and bilateral transverse–sigmoid sinus morphologies in Asian patients with venous pulsatile tinnitus
Authors: Hsieh Yue-Lin , Zuo Bo , Shi Yanhui , Wang Shenjiang , Wang Wuqing 
Published: August 2023

Objective This study was performed to investigate the dynamics of intracranial pressure (ICP) alterations and bilateral transverse–sigmoid sinus morphologies in patients with venous pulsatile tinnitus (PT). Methods This retrospective study involved 27 patients with venous PT associated with sigmoid sinus wall anomalies. ICP and ICP metrics were measured by cerebrospinal fluid manometry and internal jugular vein compression tests. Correlation analysis was performed to determine the statistical correlation between ICP and the morphological metrics. Results The mean ICP was 212.5 ± 47.3 mmH2O. The median [Formula: see text] was 130 (range, 55–150) mmH2O. The [Formula: see text] was linearly correlated with the open lumbar pressure, and a significant difference was found between patients with normal and elevated cerebrospinal fluid pressure. The [Formula: see text] was linearly correlated with the [Formula: see text] and [Formula: see text]. [Formula: see text] was linearly correlated with [Formula: see text] Conclusions Complete obstruction of flow patency should be avoided in patients with low ICP and large volumetric/patency differences in the bilateral transverse–sigmoid sinus systems.
Ligamentum teres hepatis wrapping of the gastroduodenal artery stump for protection in total laparoscopic pancreaticoduodenectomy: a single-center experience
Authors: Yu Zongdong , Wu Xiang , Zhou Xinhua , Hu Xiaodong , Lu Jun , Fang Shenzhe , Wang Luoluo , Ruan Yi , Lu Yeting , Li Hong 
Published: August 2023

Objective Hemorrhage from the stump of the gastroduodenal artery (GDA) is a significant postoperative risk with pancreaticoduodenectomy (PD). Studies have shown that wrapping the GDA stump using the omentum or the falciform ligament can help prevent bleeding. We aimed to determine whether wrapping the GDA stump with the ligamentum teres hepatis (LTH) would reduce postoperative PD hemorrhage. Methods We retrospectively reviewed data for 148 patients who underwent laparoscopic pancreatoduodenectomy (LPD) at our hospital from November 2015 to September 2021. We compared perioperative data from 63 LPD patients without wrapping of the GDA (unwrapped group) and 85 whose GDA stumps were wrapped (wrapped group). Results There were no significant differences in the groups’ baseline characteristics. The postoperative GDA stump bleeding incidence was significantly lower in the wrapped group than that in the unwrapped group (7.9% vs. 0, respectively). There was also no significant difference in the incidence of other complications (intra-abdominal infection, postoperative pancreatic fistula (POPF), biliary fistula, and gastrointestinal bleeding). Conclusion Using the LTH to wrap the GDA stump during LPD can reduce bleeding from the GDA stump but not the incidence of other complications.
Orofacial pain for clinicians: A review of constant and attack-like facial pain syndromes
Authors: May Arne , Benoliel Rafael , Imamura Yoshiki , Pigg Maria , Baad-Hansen Lene , Svensson Peter , Hoffmann Jan 
Published: August 2023

BackgroundPrimary headache syndromes such as migraine are among the most common neurological syndromes. Chronic facial pain syndromes of non-odontogenic cause are less well known to neurologists despite being highly disabling. Given the pain localization, these patients often consult dentists first who may conduct unnecessary dental interventions even if a dental cause is not identified. Once it becomes clear that dental modalities have no effect on the pain, patients may be referred to another dentist or orofacial pain specialist, and later to a neurologist. Unfortunately, neurologists are also often not familiar with chronic orofacial pain syndromes although they share the neural system, i.e., trigeminal nerve and central processing areas for headache disorders.ConclusionIn essence, three broad groups of orofacial pain patients are important for clinicians: (i) Attack-like orofacial pain conditions, which encompass neuralgias of the cranial nerves and less well-known facial variants of primary headache syndromes; (ii) persistent orofacial pain disorders, including neuropathic pain and persistent idiopathic facial/dentoalveolar pain; and (iii) other differential diagnostically relevant orofacial pain conditions encountered by clinicians such as painful temporomandibular disorders, bruxism, sinus pain, dental pain, and others which may interfere (trigger) and overlap with headache. It is rewarding to know and recognize the clinical picture of these facial pain syndromes, given that, just like for headache, an internationally accepted classification system has been published and many of these syndromes can be treated with medications generally used by neurologists for other pain syndromes.
Student Loan Debt Response to Tuition Changes
Authors: Dowdy Zachary Jacob , Dacass Tennecia 
Published: August 2023

Amid rising concerns regarding student loan debt, we examine the effect of Washington State’s College Affordability Program introduced in 2015 on undergraduate student loan debt to provide policy-makers with additional tools to help prevent another student loan debt crisis. The program reduced tuition for resident full-time undergraduate students at public colleges and universities for two consecutive academic years. This policy adoption created a natural experiment that we exploit to identify a causal link between tuition and loans. Using college-level data for the 2009–2010 through 2021–2022 academic years and employing a difference-in-differences model in conjunction with nearest-neighbor matching, we show that a decrease in college tuition following the adoption of the College Affordability Program caused a $637.96 (9 percentage-point) decline in average loans among first-time, full-time undergraduates in Washington State relative to undergraduates from matched U.S. schools. JEL Codes: G28, I22
HEI employer-engagement – a practitioner's reflections using institutional logics lenses
Authors: McAllister Katie 
Published: August 2023

Higher Education Institutions (HEIs) are increasingly engaging with businesses to provide opportunities for their students whilst also promoting their own relevance and impact in society. However, this engagement often involves navigating multiple internal processes and practices. This paper presents an employer-engagement practitioner's reflections on HEI employer-engagement, using the lens of two institutional logics – professional and corporate logics. This paper considers how these logics are shaping HEI employer-engagement, the challenges for employer engagement middle managers (EE-MM), and tensions with senior leadership teams (SLT). This paper is framed and located from the point of view of a middle manager working within employer engagement, reflecting the challenges being faced by myself and seven other EE-MM across five English HEIs as part of my doctoral research. It explores the tensions between EE-MM and HEI-wide SLT; highlighting the competing demands between day-to-day management and strategic overview.
Heterogeneity in practitioner-reported barriers to use, cost considerations and priorities for point of care sexually transmitted infection tests on surveys across seven years
Authors: Tuddenham Susan , Hsieh Yu-Hsiang , Manabe Yukari C , Gaydos Charlotte Ann , Rompalo Anne 
Published: August 2023

Background Point of care diagnostic tests (POCTs) for sexually transmitted infections (STIs) have the potential to improve STI care worldwide. However, barriers to adoption, cost considerations and practitioner priorities may not be uniform globally and over time. We conducted two surveys, 7 years apart, among members of the International Union Against Sexually Transmitted Infections (IUSTI), and compare results here. Methods Surveys were given to members attending two IUSTI conferences in 2012 (Australia) and 2019 (Estonia). Descriptive analyses were performed and chi-square or Fisher’s exact tests conducted. Results Amongst N = 190 participants in 2012 and N = 166 in 2019, 61% in 2012 and 77% in 2019 were from high-income countries (HICs). In 2012, 84% of respondents from low- and middle-income countries (LMICs) and 70% from HICs thought cost of test was more important than amount of reimbursement. Trends were similar in 2019. In 2012, unreliability was considered the most important barrier to POCT use by all groups, followed by being laboratory-driven and complexity. In 2019, time frame was considered most important, followed by unreliability and being laboratory-driven. In 2012, the top priority for POCT development among LMIC respondents was early HIV seroconversion (31%), versus chlamydia (57%) for HICs. In 2019, chlamydia remained top priority for HICs (40%), followed by early HIV seroconversion (19%) and gonorrhea (17%); top priorities for LMICs were chlamydia (26%), HPV (24%), and early HIV seroconversion (21%). Conclusions Practitioner priorities for STI POCTs may be shifting. Cost may be critical to adoption in all settings. Larger studies are needed to verify findings.
Corilagin Induces ROS-mediated Apoptosis and Triggers Cell-Cycle Arrest at G0/G1 Stage in Osteosarcoma Cells
Authors: Liu Jichao , Yang Dong , Liu Jianyu 
Published: August 2023

Background Osteosarcoma (OS) is an extremely aggressive primary bone cancer (BC) malignancy. A variety of malignancies can develop in the bones, including BC. Primary BCs are tumors that start in the bone. Bones can also become affected by tumors that start in the body’s organs or other tissues. Objectives Several reports suggested that corilagin (CL) exerts anticancer properties on various kinds of tumor cells; however, its molecular action on OS cells remains undefined. Materials and Methods The CL activity of OS cells’ cytotoxicity, intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), apoptosis, and cell-cycle distribution was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, dichloro-dihydro-fluorescein diacetate (DCFH-DA), Rh-123, acridine orange and ethidium bromide (AO/EB), 4′,6-diamidino-2-phenylindole (DAPI), and flow cytometry analysis. Results Results revealed that CL could suppress OS cell proliferation via enhanced intracellular ROS, and MMP loss, and triggered apoptosis in a dose-dependent has an inferior manner. Our findings demonstrated that CL alleviates U2OS and MG-63 cell proliferation by the ROS-mediated apoptosis, which triggers G0/G1 cell-cycle arrest. Conclusion Thus, CL might be a protective therapeutic agent against BC.
Dr. ChatGPT: Utilizing Artificial Intelligence in Surgical Education
Authors: Lebhar Michael S. , Velazquez Alexander , Goza Shelby , Hoppe Ian C. 
Published: August 2023

Objective This study sought to explore the unexamined capabilities of ChatGPT in describing the surgical steps of a specialized operation, the Fisher cleft lip repair. Design A chat log within ChatGPT was created to generate the procedural steps of a cleft lip repair utilizing the Fisher technique. A board certified craniomaxillofacial (CMF) surgeon then wrote the Fisher repair in his own words blinded to the ChatGPT response. Using both responses, a voluntary survey questionnaire was distributed to residents of plastic and reconstructive surgery (PRS), general surgery (GS), internal medicine (IM), and medical students at our institution in a blinded study. Setting Authors collected information from residents (PRS, GS, IM) and medical students at one institution. Main Outcome Measures Primary outcome measures included understanding, preference, and author identification of the procedural prompts. Results Results show PRS residents were able to detect more inaccuracies of the ChatGPT response as well as prefer the CMF surgeon's prompt in performing the surgery. Residents with less expertise in the procedure not only failed to detect who wrote what procedure, but preferred the ChatGPT response in explaining the concept and chose it to perform the surgery. Conclusions In applications to surgical education, ChatGPT was found to be effective in generating easy to understand procedural steps that can be followed by medical personnel of all specialties. However, it does not have expert capabilities to provide the minute detail of measurements and specific anatomy required to perform medical procedures.
Quantification and severity grading of femoral vessel compression by adverse reactions to metal debris in metal-on-metal total hip arthroplasty
Authors: Al-Khatib Yousef , Tyas Ben , Kalson Nicholas S , Agni Nickil , Bhutani Priyesh , Petheram Timothy , Carluke Ian , Partington Paul 
Published: August 2023

Introduction: Metal-on-metal (MoM) total hip arthroplasty (THA) may cause adverse reactions to metal debris (ARMD). ARMD causing femoral vessel compression with serious complications has been described in case reports, but the rate of compression by ARMD is not known. This study aims to investigate the rate, and quantify the severity, of femoral vessel compression in MoM hips with ARMD lesions. Methods: Patients under surveillance for MoM THA investigated with MRI were studied. In patients with confirmed ARMD, femoral artery (FA) and vein (FV) diameters were measured at the point of maximal compression and compared to contralateral vessels. The primary outcome measure was presence or absence of compression. Cases were then classified by compression ratios. Secondary outcome measures were rates of deep vein thrombosis, revision surgery and time to ARMD from index procedure. Results: MRI scans for 436 patients with MoM THA were screened. Of these, 211/436 (48.4%) showed evidence of ARMD. Measurements were obtained on 133/211 (63.0%) patients. The FV was compressed in 102/133 (76.7%) and FA in 58/133 (43.6%), while 31/133 (23.3%) patients had no compression. In FVs, 42 demonstrated mild compression, 39 moderate and 21 severe. In FAs, none were severely compressed, 6 were moderate and 52 showed mild compression. There were 3 DVT cases, 2 in patients with moderate FV compression and 1 in patients without FV compression. Revision rates were highest in patients with severe FV compression (14/21, 66.7%). The mean time for MRI-diagnosed ARMD from index procedure was 8 years and 1 month (range 11 months–14.5 years). Conclusions: Extra-luminal compression of the femoral vessels was found in >75% of patients with ARMD. Although it is not clear whether revision for femoral vessel compression is required, quantification of FV compression may be useful for surgeons and radiologists considering revision for ARMD.