bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spectrum of eating environments encountered in free living adults documented using a passive capture food intake wearable device
Authors: Breit Matthew , Padia Jonathan , Marden Tyson , Forjan Dan , Zhaoxing Pan , Zhou Wenru , Ghosh Tonmoy , Thomas Graham , McCrory Megan A. , Sazonov Edward , Higgins Janine 
Published: May 2023

IntroductionThe aim of this feasibility and proof-of-concept study was to examine the use of a novel wearable device for automatic food intake detection to capture the full range of free-living eating environments of adults with overweight and obesity. In this paper, we document eating environments of individuals that have not been thoroughly described previously in nutrition software as current practices rely on participant self-report and methods with limited eating environment options.MethodsData from 25 participants and 116 total days (7 men, 18 women, Mage = 44 ± 12 years, BMI 34.3 ± 5.2 kg/mm2), who wore the passive capture device for at least 7 consecutive days (≥12h waking hours/d) were analyzed. Data were analyzed at the participant level and stratified amongst meal type into breakfast, lunch, dinner, and snack categories. Out of 116 days, 68.1% included breakfast, 71.5% included lunch, 82.8% included dinner, and 86.2% included at least one snack.ResultsThe most prevalent eating environment among all eating occasions was at home and with one or more screens in use (breakfast: 48.1%, lunch: 42.2%, dinner: 50%, and snacks: 55%), eating alone (breakfast: 75.9%, lunch: 89.2%, dinner: 74.3%, snacks: 74.3%), in the dining room (breakfast: 36.7%, lunch: 30.1%, dinner: 45.8%) or living room (snacks: 28.0%), and in multiple locations (breakfast: 44.3%, lunch: 28.8%, dinner: 44.8%, snacks: 41.3%).DiscussionResults suggest a passive capture device can provide accurate detection of food intake in multiple eating environments. To our knowledge, this is the first study to classify eating occasions in multiple eating environments and may be a useful tool for future behavioral research studies to accurately codify eating environments.
Single-nucleus ribonucleic acid-sequencing and spatial transcriptomics reveal the cardioprotection of Shexiang Baoxin Pill (SBP) in mice with myocardial ischemia-reperfusion injury
Authors: Lin Wenyong , Chen Xin , Wang Dongyuan , Lu Ruixia , Zhang Chunling , Niu Zhenchao , Chen Jie , Ruan Xiaofen , Wang Xiaolong 
Published: May 2023

Graphical AbstractSingle-cell landscape of SBP treatments in a mouse model of myocardial I/R injury. A total of 75,546 cells from nine mouse cardiac tissues in 3 different groups are projected by UMAP plot. The four colored tracks (from inside to outside) indicate cluster, origin ID, group and cell type. The axis outside the circular plot depicts the scale of the total cell number for each class. The text in each of the four corners show an overview of the role of SBP on cardiomyocytes, endothelial cells, fibroblasts, and macrophages respectively. Legends denote the origin ID, group, cell type and cluster.
A multinational cross-sectional study on the awareness and concerns of healthcare providers toward monkeypox and the promotion of the monkeypox vaccination
Authors: Swed Sarya , Alibrahim Hidar , Bohsas Haidara , Jawish Nagham , Rais Mohammed Amir , Nasif Mohamad Nour , Hafez Wael , Sawaf Bisher , Abdelrahman Ahmed , Fathey Sherihan , Atef Ismail Ahmed Ibrahim Ismail , Almashaqbeh Sondos Hussein Ahmad , Yousef Aljawarneh Razan Mohammad , Rakab Amine , EL-Shafei Emad Hassan Hassan , Hurlemann Rene , Elsayed Mohamed E. G. ,   Data Collection Group
Published: May 2023

BackgroundThe aim of this study was to explore potential healthcare workers' (HCWs) concerns about the monkeypox virus in order to create practical solutions to manage this disease.MethodsOnline cross-sectional research was conducted in 11 Arabic countries (Egypt, Saudi Arabia, Yemen, Syria, Libya, Algeria, Tunisia, Iraq, Palestine, Jordan, and Sudan) from 2 August 2022 to 28 December 2022.ResultsApproximately 82% of respondents felt the need to acquire further information. The acceptability of the vaccine against monkeypox has been indicated by more than half of the participants (54.5%). Furthermore, we state that 45% of the participants are knowledgeable about the monkeypox virus, and 53.1% of the participants have never been affected with COVID-19 before are more worried about COVID-19 than about monkeypox. Participants diagnosed with COVID-19 were 0.63 times less likely to worry about monkeypox than those who were not diagnosed with COVID-19. A greater willingness to get the monkeypox vaccination was seen among the age group 21–30 years (42.4%) compared to the other age groups.ConclusionMost healthcare professionals have a moderate knowledge of the monkeypox virus. Furthermore, they demonstrated a low willingness to get the vaccination against the monkeypox virus.
Factors predicting the active treatment of renal angiomyolipoma: 30 years of experience in two tertiary referral centers
Authors: Daché Arnaud , Fatica Richard , Herts Brian R. , McLennan Gordon , Remer Erick M. , Haber Georges-Pascal , Ouzaid Idir 
Published: May 2023

Introduction and objectiveThis study aimed to identify clinical features representing predictive factors of active treatment (AT) compared to active surveillance (AS) for renal angiomyolipoma (AML).Patients and methodsFrom 1990 to 2020, patients referred to two institutions for a renal mass and diagnosed with an AML based on typical features on CT were included in the analysis. The study population was divided into two groups based on the treatment received: active surveillance (AS) or active treatment (AT). Age, gender, tuberous sclerosis syndrome, tumor size, contralateral kidney disease, renal function, year of diagnosis, and symptoms at presentation were assessed as potential predictive factors of active treatment using a logistic regression model in univariate and multivariate analyses.ResultsIn total, 253 patients (mean age 52.3 ± 15.7 years; 70% women; 70.9% incidentally diagnosed) were included in the analysis. One hundred and nine (43%) received AS, whereas 144 (57%) were actively treated. For univariate analysis, age, tuberous sclerosis complex syndrome, tumor size, symptoms at presentation, and contralateral kidney disease were found to be predictors of AT. Only tumor size (p &lt; 0.001) and the year of diagnosis (p &lt; 0.001) remained significant for multivariable analyses. The likelihood of being managed with AS evolved over the study period and was 50% and 75% when diagnosed before and after 2010, respectively. With respect to size, 4-cm and 6-cm tumors had a probability of 50% and 75% of being treated with AS, respectively.ConclusionThe present analysis from a high-volume institution provides evidence that the management of renal masses with typical radiological features of AML has markedly changed over the last three decades with a trend toward AS over AT. Tumor size and the year of diagnosis were significant factors for the treatment strategies.
Normothermic Ex Vivo Machine Perfusion of Discarded Human Pancreas Allografts: A Feasibility Study
Authors: Parmentier Catherine , Ray Samrat , Mazilescu Laura I. , Kawamura Masataka , Noguchi Yuki , Nogueira Emmanuel , Ganesh Sujani , Arulratnam Bhranavi , Kalimuthu Sangeetha N. , Selzner Markus , Reichman Trevor W. 
Published: May 2023

Pancreas transplantation is the only curative treatment for patients with complicated diabetes, and organ shortage is a common and increasing problem. Strategies to expand the donor pool are needed, and normothermic ex vivo perfusion of the pancreas has the potential to test and repair grafts before implantation. Between January 2021 and April 2022, six human pancreases, declined for transplantation or islet isolation, were perfused using a previously established method by our group. All 6 cases were successfully perfused for 4 h, with minimal edema. The mean age of the donors was 44.16 ± 13.8 years. Five grafts were obtained from neurological death donors, and one was obtained from a donation after cardiac death. The mean glucose and lactate levels decreased throughout perfusion and insulin levels increased. All 6 grafts were metabolically active during perfusion and histopathology showed minimal tissue injury and no edema. Human normothermic ex vivo perfusion of the pancreas is feasible and safe and has the potential to expand the donor pool. Future studies will focus on tests and biomarkers for the assessment of grafts.
The Crystal Structure of Manganotychite, Na6Mn2(CO3)4(SO4), and Structural Relations in the Northupite Group
Authors: Krivovichev Sergey V. , Panikorovskii Taras L. , Bazai Ayya V. , Sidorov Mikhail Yu. 
Published: May 2023

The crystal structure of manganotychite has been refined using the holotype specimen from the Alluaiv Mountain, Lovozero massif, Kola peninsula, Russia. The mineral is cubic, Fd3¯, a = 14.0015(3) Å, V = 2744.88(18) Å3, Z = 8, R1 = 0.020 for 388 independently observed reflections. Manganotychite is isotypic to tychite and ferrotychite. Its crystal structure is based upon a three-dimensional infinite framework formed by condensation of MnO6 octahedra and CO3 groups by sharing common O atoms. The sulfate groups and Na+ cations reside in the cavities of the octahedral-triangular metal-carbonate framework. In terms of symmetry and basic construction of the octahedral-triangular framework, the crystal structure of manganotychite is identical to that of northupite, Na3Mg(CO3)2Cl. The transition northupite → tychite can be described as a result of the multiatomic 2Cl− → (SO4)2− substitution, where both chlorine and sulfate ions are the extra-framework constituents. However, the positions occupied by sulfate groups and chlorine ions correspond to different octahedral cavities within the skeletons of Na atoms. The crystal structure of northupite can be considered as an interpenetration of two frameworks: anionic [Mg(CO3)2]2− octahedral-triangular framework and cationic [ClNa3]2− framework with the antipyrochlore topology. Both manganotychite and northupite structure types can be described as a modification of the crystal structure of diamond (or the dia net) via the following steps: (i) replacement of a vertex of the dia net by an M4 tetrahedron (no symmetry reduction); (ii) attachment of (CO3) triangles to the triangular faces of the M4 tetrahedra (accompanied by the Fd3¯m → Fd3¯ symmetry reduction); (iii) filling voids of the resulting framework by Na+ cations (no symmetry reduction); and (iv) filling voids of the Na skeleton by either sulfate groups (in tychite-type structures) or chlorine atoms (in northupite). As a result, the information-based structural complexity of manganotychite and northupite exceeds that of the dia net.
Benefits of Polyphenol-Based Synbiotics in Crustacean Diet
Authors: Sateriale Daniela , Facchiano Serena , Kaldre Katrin , Forgione Giuseppina , De Cristofaro Giuseppa Anna , Pagliarulo Caterina , Paolucci Marina 
Published: May 2023

Here, the olive leaf extract (OLE) rich in polyphenols was employed as a prebiotic agent, together with Lactobacillus reuteri and Bacillus clausii, to develop synbiotics. The prebiotic effect of olive leaf extract on the probiotic strains was tested at concentrations of 0, 50, 100, 400, and 1000 μg mL−1, and also 20 and 40 mg mL−1. Olive leaf extract at 40 mg mL−1 showed the best prebiotic activity on L. reuteri and B. clausii. A basal diet and two experimental synbiotic-containing diets were prepared. The synbiotic diets were manufactured by adding to the basal diet 5 × 106 CFU g−1 L. reuteri + 5 × 106 CFU g−1 B. clausii + 0.25 mg g−1 OLE and 1 × 107 CFU g−1 L. reuteri + 1 × 107 CFU g−1 B. clausii + 0.25 mg g−1 OLE. The diets were administered to the freshwater crayfish Astacus astacus (1.35 ± 0.04 g) in an 84-day feeding trial. The diet containing 5 × 106 CFU g−1 L. reuteri + 5 × 106 CFU g−1 B. clausii + 0.25 mg g−1 OLE significantly improved (p < 0.05) final weight, specific growth rate, body condition, and survival rate. A significant growth of Enterobacteriaceae, which include strains with proven beneficial activities for intestinal health and general animal welfare, significantly increased in crayfish fed with synbiotics. The obtained results could be suitable for functional feed development in crayfish farming.
Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed
Authors: Di Paola Rossella , De Ananya , Capasso Anna , Giuliana Sofia , Ranieri Roberta , Ruosi Carolina , Sciarra Antonella , Vitagliano Caterina , Perna Alessandra F. , Capasso Giovambattista , Simeoni Mariadelina 
Published: May 2023

Thyroid cancers require complex and heterogeneous therapies with different impacts on renal function. In our systematic literature review, we analyzed several aspects: renal function assessment, the impact of radiotherapy and thyroid surgery on kidney functioning, and mechanisms of nephrotoxicity of different chemotherapy, targeted and immunologic drugs. Our study revealed that the renal impact of thyroid cancer therapy can be a limiting factor in all radiotherapy, surgery, and pharmacological approaches. It is advisable to conduct a careful nephrological follow-up imposing the application of body surface based estimated Glomerular Filtration Rate (eGFR) formulas for the purpose of an early diagnosis and treatment of renal failure, guaranteeing the therapy continuation to thyroid cancer patients.
THE BULLS BREED DIFFERENCES IMPACT ON THE CHEMICAL COMPOSITION AND BIOLOGICAL VALUE OF BEEF OBTAINED FROM THEM
Authors: ГОРЛОВ И.Ф. , СЛОЖЕНКИНА М.И. , НИКОЛАЕВ Д.В. , МИРОШНИК А.С. , МОСОЛОВА Д.А. , ЧЕРНИКОВ Е.В. 
Published: May 2023

В статье представлены результаты анализа морфологического состава и биологической ценности белков мышечной ткани бычков русской комолой и калмыцкой пород типа Айта. Опыт проводили в условиях племенного хозяйства, расположенного на территории Нижнего Поволжья. Кормление животных осуществляли из расчета на получение среднесуточных приростов живой массы 1000—1100 г. Бычков содержали на свободновыгульных кормовых площадках. Контрольный убой 5 особей из каждой опытной группы показал превосходство молодняка русской комолой породы по выходу туши на 1,03% и убойному выходу — на 0,93% по сравнению со сверстниками калмыцкой породы. По результатам обвалки правых полутуш было установлено превышение массы мякоти и снижение выхода мякоти II сорта на 3,13 и 1,44% соответственно у бычков русской комолой породы. Длиннейшая мышца спины этих животных отличалась повышенным значением белково-качественного показателя на 2,64%, более низкими массовыми долями сухого вещества — на 0,4% и жира — на 0,1% по сравнению с их сверстниками калмыцкой породы. В ней зафиксировано превышение доли полноценных саркоплазматических белков на 0,36% (P≤0,01). Микроструктура мышцы отличалась более выраженной «мраморностью»: прослеживались четкие границы жировых прослоек и волокон с липидными включениями. Полученные данные следует использовать для выработки практических рекомендаций по производству конкурентоспособной говядины в условиях Нижнего Поволжья.
The article presents the morphological composition and biological value of muscle tissue of Russian Hornless and Kalmyk Aita-type bulls analysis results. The experiment was conducted in a breeding farm located in the Lower Volga region. Feeding of animals was performed to ensure the average daily live weight gain were 1000—1100 g. The bulls were kept on free-range feedlots. The control slaughter of 5 animals from each experimental group showed the superiority of Russian Hornless breed of young cattle in carcass yield by 1.03% and slaughter yield by 0.93% compared to their peers of Kalmyk breed. According to the right half-carcasses deboning results, an excess of flesh weight and a decrease in grade II flesh yield in the Russian Hornless breed bulls by 3.13 and 1.44%, respectively, were determined. The longissimus dorsi muscle of these animals had an increased protein-quality index by 2.64%, a reduced mass fractions of dry matter — by 0.4% and fat — by 0.10% compared to their peers of the Kalmyk breed. It recorded a sarcoplasmic complete proteins share excess by 0,36% (P≤0.01). The muscle microstructure was characterized by a more pronounced "marbling": clear outlines of fat layers and fibers with lipid inclusions were observed. The data obtained should be used in practical recommendations development for competitive beef production in conditions of the Lower Volga region.
RANCANG BANGUN PENDETEKSI PELANGGARAN LAMPU LALU LINTAS BERBASIS MIKROKONTROLER DAN SMS GATEWAY
Authors: Siregar Ryan Sihopong Parlindungan , Kurniabudi Kurniabudi , Pahlevi M. Riza 
Published: May 2023

ABSTRAK
Pelanggaran lalu lintas hingga saat ini menjadi kebiasaan masyarakat di sebagian besar kota-kota di Indonesia. Jenis-jenis pelanggaran yang dilakukan yaitu tidak memakai sabuk pengaman saat berada di mobil, melawan arus, tidak membawa kelengkapan surat kendaraan, menerobos lampu lalu lintas di persimpangan lampu lalu lintas dan lain-lain. Menurut WHO, kecelakaan lalu lintas telah memakan korban jiwa sekitar 2,4 juta jiwa manusia setiap tahunnya. Jumlah angka kematian yang diakibatkan kecelakaan lalu lintas ini menduduki peringkat ketiga sebagai penyebab kematian setelah HIV/AIDS dan TBC. Oleh karena itu dirancang alat Pendetek Pelanggaran Lampu Lalu Lintas Berbasis Mikrokontroller dan SMS Gateway. Alat ini menggunakan Arduino Uno sebagai librari dari sensor jarak (HC-SR04), hasil dari proses mikrokontroler ini akan mengaktifkan sensor Ultrasonik yang mana mendeteksi Pelanggaran yang terjadi ketika lampu sedang berwarna merah sebagai tanda bahwa sensor berkerja sesuai dengan rancangan. Alat yang dirancang dapat berkerja dengan baik dan memberikan kemudahan kepada pihak kepolisian dalam mentertibkan lalu lintas dan juga mengetahui siapa saja yang telah melakukan pelanggaran menerobos lampu merah.
Kata Kunci : Pendeteksi Pelanggaran, Lampu Lalu Lintas, Arduino Uno, SMS Gateway, Sensor Ultrasonik
PELATIHAN PEMBUATAN BAHAN AJAR INTERAKTIF MENGGUNAKAN QUIZIZZ UNTUK GURU - GURU SD NEGERI 108 / IV KOTA JAMBI
Authors: Amroni  , Irawan Beni , Riyadi Willy , Harris Abdul 
Published: May 2023

Perkembangan Teknologi Informasi dan komunikasi mendorong pendidik (guru) agar dapat memanfaatkan aplikasi penunjang pembelajaran bahan ajar interaktif sehingga para siswa/i lebih tetarik dalam belajar. Quizizz adalah salah satu alternatif aplikasi media pembelajaran interaktif yang berbasis web serta dapat dimanfaatkan oleh para pendidik (guru) untuk membentuk kuis yang dapat dikerjakan secara online. SD Negeri 108 / IV Kota Jambi yang berada di Jl. Marsda Iswahyudi, Pasir Putih, Kec. Jambi Sel., Kota Jambi, 36139. Permasalahan utama yang dihadapi guru – guru di sekolah ini yaitu kurangnya pemahaman tentang pembuatan media belajar interaktif agar siswa/i tertarik dalam belajar serta mengasah kemampuan siswa/i di SD Negeri 108 / IV Kota Jambi. Sehingga diperlukan penyuluhan dalam bentuk Pengabdian Kepada Masyarakat (PKM) kepada guru – guru di SD Negeri 108 / IV Kota Jambi dengan tema “Pelatihan Pembuatan Pembuatan Bahan Ajar Interaktif Menggunakan Quizizz Untuk Guru – Guru SD Negeri 108 / IV Kota Jambi” agar para guru – guru mampu membuat media belajar interaktif dengan Ms. Office dan Quizizz.
Single-Nephron GFR in Different Glomerular Basement Membrane Stages of Membranous Nephropathy
Authors: Okabayashi Yusuke , Tsuboi Nobuo , Marumoto Hirokazu , Sasaki Takaya , Haruhara Kotaro , Kanzaki Go , Koike Kentaro , Ueda Hiroyuki , Shimizu Akira , Puelles Victor G. , D'Agati Vivette , Yokoo Takashi 
Published: May 2023

Key Points

The first study that estimated single-nephron GFR (SNGFR) in patients with membranous nephropathy (MN).Associations of SNGFR with MN staging by electron microscopy and clinicopathologic findings were cross-sectionally investigated.This study illustrates a role for disease-specific GBM structural lesions as determinants of SNGFR in patients with MN.

Background
Alterations in single-nephron dynamics have been demonstrated in animal models of membranous nephropathy (MN). This study applied a recently developed technique to estimate single-nephron parameters in human MN.

Methods
Single-nephron GFR (SNGFR) and single-nephron urinary protein excretion (SNUPE) were calculated by dividing total GFR and UPE by the total estimated number of nonglobally sclerotic glomeruli (NSG). The NSG number per kidney was estimated using cortical volume assessment and biopsy-based stereology. MN staging by electron microscopy was performed using Ehrenreich-Churg (EC) criteria. Single-nephron parameters were analyzed in relation to clinicopathological factors known to associate with disease outcomes.

Results
The study included 109 patients with MN (mean age 65 years; 73% male; eGFR 62 ml/min, 36% on renin-angiotensin-aldosterone system inhibitors prebiopsy). EC stages were I, 19%; II, 49%; III, 26%; and IV, 6%. There was no difference in glomerular volume among EC stage groups. With advancing EC stage, SNGFR and SNUPE decreased from mean 56–42 nl/min and 5.1–3.8 µg/d, respectively. In multivariable models, EC stage was associated with SNGFR even after adjustment for key clinicopathological factors, such as reduced GFR, serum albumin, UPE, segmental glomerulosclerosis, chronic tubulointerstitial damage, and prebiopsy use of renin-angiotensin-aldosterone system inhibitors. By contrast, EC stage was not associated with glomerular volume and SNUPE after multivariable adjustment.

Conclusions
These results provide the first clinical evidence of alterations in single-nephron dynamics with advancing EC stage of human MN and support a role for disease-specific glomerular basement membrane structural lesions as determinants of SNGFR.
High Albumin Clearance Predicts the Minimal Change Nephrotic Syndrome Relapse
Authors: Kuno Hideaki , Kanzaki Go , Sasaki Takaya , Haruhara Kotaro , Okabe Masahiro , Yokote Shinya , Koike Kentaro , Tsuboi Nobuo , Yokoo Takashi 
Published: May 2023

Key Points

Albumin kinetics not only reflected the pathophysiology of minimal change nephrotic syndrome but was also a predictor of relapse.The high estimated 24-hour albumin clearance predicts the minimal change nephrotic syndrome relapse.The 24-hour albumin clearance can easily be calculated from only serum albumin and urinary protein excretion, which are routine laboratory measurements.

Background
Although albuminuria leakage that occurs in minimal change nephrotic syndrome (MCNS) may be related to the disease state, albumin kinetics in MCNS has never been evaluated. In this study, we investigated albumin kinetics in adult Japanese patients with MCNS by the estimated 24-hour albumin clearance (eCALB) and examined the association between eCALB and relapse.

Methods
We retrospectively identified 103 adult patients with a histological diagnosis of MCNS from four hospitals in Japan (2010–2020). The primary outcome is the first relapse in 2 years after complete remission after corticosteroid therapy. The eCALB [µl/min] was defined as (2.71828(0.0445+0.9488×log(urinary protein) [g/24 hours])/(serum albumin [g/dl]×1440 [min/24 hours]) for women and (2.71828(-0.1522+0.9742×log(urinary protein) [g/24 hours])/(serum albumin [g/dl]×1440 [min/24 hours]) for men.

Results
Relapse was observed in 44 patients (103 kidney biopsy samples; 42.7%). The mean patient age was 41.0 years. Patients had an eGFR of 71.0 ml/min per 1.73 m2, urinary protein excretion of 6.8 g/d, serum albumin of 1.4 g/dl, and eCALB of 2.27 μl/min. eCALB was strongly associated with hypoalbuminemia, severe proteinuria, lipid abnormalities, and coagulopathy. In the multivariable analysis, a high eCALB was significantly associated with relapse after adjusting for age, eGFR, time to complete remission, and urinary protein excretion (adjusted hazard ratio, 5.027; 95% confidence interval, 1.88 to 13.47; P = 0.001).

Conclusions
This study revealed that eCALB, which could substitute albumin kinetics, reflected the severity of MCNS, and a high eCALB was associated with recurrence.