bluuebunny/crossref_metadata_2025_split huggingface dataset:
RELAWAN DEMOKRASI PADA PEMILU TAHUN 2019 DI DISTRIK HERAM
Authors: Usman Syamsudin , Sahriani Sahriani , Klaru Apner 
Published: February 2023

Tingkat partisipasi pemilih pada setiap Pemilu selalu mengalami pasang surut. Dinamika partisipasi pemilih ini merupakan salah satu indicator dalam mewujudkan demokrasi di sebuah negara. Peneletian ini bertujuan untuk melihat seberapa besar dampak dari dibentuknya relawan demokrasi untuk meningkatkan kesadaran pemilih menyampaikan hak konstitusinya dengan memberikan suaranya di tempat pemungutan suara (TPS).
Metode yang digunakan oleh penulis dalam penelitian ini adalah dengan menentukan responden secara bertujuan sesuai dengan topik yang akan diteliti, merumuskan daftar pertanyaan yang akan digunakan saat wawancara dengan responden. Selain menggunakan Teknik wawancara, penulis juga menggunakan Teknik observasi dan studi literatur/kajian kepustakaan untuk memperkaya tulisan ini. Studi literatur/kajian Pustaka dengan menggunakan tulisan-tulisan sebelumnya yang ada relevansinya dengan topik yang diteliti selain buku-buku teks.
Dari penelitian ini dapat disimpulkan bahwa relawan demokrasi merupakan salah satu upaya yang dilakukan oleh Komisi Pemilihan Umum (KPU) untuk meningkatkan partisipasi pemilih pada pemilu 2019. Namun demikian kelompok ini belum sepenuhnya dikenal oleh masyarakat umum terutama masyarakat yang ada di Distrik Heram. KPU Kota Jayapura belum memaksimalkan peran dari relawan domokrasi. Kecenderungan partisipasi pemilih di Distrik Heram yang meningkat tidak dikarenakan peran relawan demokrasi. untuk meningkatkan partisipasi pemilih pada Pemilu kedepannya maka relawan demokrasi harus di isi oleh sumberdaya manusia yang memahami seluk beluk tentang kepemiluan dan mempunyai kepedulian yang tinggi terhadap Pemilu. Selain relawan demokrasi, harus juga digunakan metode pendekatan melalui tokoh-tokoh pemuda, kaum perempuan, adat, agama, tokoh masyarakat dan lembaga-lembaga pendidikan secara masiv agar dapat meningkatkan partisipasi pemilih dalam Pemilu khusunya di Distrik Heram
Experimenting on the Enactment of Predictive AI: The Quest for a Future Proactive Healthcare Sector
Authors: Henriksen Anne , Olesen Finn 
Published: February 2023

Currently, a large number of AI projects are experimenting with the use of AI and big data for various purposes, especially in the public sector. In this article, we explore one such AI project. Specifically, we study a group of developers in Scandinavia and their efforts to enact predictive AI through the development of a clinical decision support system (CDSS) in pursuit of a future proactive healthcare sector. This yet-to-be system was envisioned to prevent unplanned hospitalizations by ‘turning’ what we term ‘potential patients’, i.e. the effective management of patient trajectories, in pursuit of a proactive healthcare sector. In the article, we investigate this particular project as an ‘experiment’ and conceptualize the developing CDSS as a ‘partially existing object’ with an uncertain ontological status. By studying the gradual enactment and emergence of the CDSS, we illuminate how this fuzzy data-driven object is performed and gradually attributed with solid reality: during its creation process, it advances from being a proactive device imagined to be used in primary healthcare to becoming a triage tool embedded in the prehospital emergency department. Along the way, the project developers are also transformed, learning what ‘moves’ and ‘actions’ to make, and, thereby, becoming skillful CDSS-operators. By using ‘experiment’ as our analytical lens, the article renders visible how persons, locations, and procedures have to be changed, revoked, and suspended in order for the AI project to succeed. Thus, the article contributes to showing how ‘social mangling’ is an essential precondition for predictive AI to succeed as a prolific solution to specific healthcare challenges, along with developers’ learning and transformation.
En styringsteknologi bliver til
Authors: Stilling Olesen Jesper 
Published: February 2023

Hos Michel Foucault og Nikolas Rose er magt ikke noget, man besid-­‐der, men noget der skal udføres og derfor betinget af handlinger og intentioner hos de, som søges styret. Alligevel fremstilles styringstek-­‐nologier i governmentality litteraturen ofte som mere eller mindre direkte afledt af beskrivelser i policy-­‐papirer. De interesserer sig først og fremmest for at studere, hvordan færdige styringsteknologier gri-­‐ber ind i menneskers liv og medvirker til, at subjekter bliver til på be-­‐stemte måder. En styringsteknologi har en tilblivelseshistorie, der er værd at beskrive. Denne artikel viser gennem en Latourinspireret ana-­‐lyse af en implementeringsproces, hvordan en lov udfoldes som trans-­‐lationer i et netværk. Analysen følger implementeringen af loven om pædagogiske læreplaner i dagtilbud med henblik på at identificere koblinger mellem viden, magt og subjektivitet og andre aktanter, der danner grundlag for, at loven kan fungere som en styringsteknologi for arbejdet i dagtilbud. Analysen bidrager til en nuancering af vores forståelse af policy som flydende og med et element af uforudsigelig-­‐hed, som ikke indfanges af governmentalitystudier, der studerer lov-­‐givningsprocesser ud fra et styringseffektperspektiv.
The Responsive Raid
Authors: Boll Karen 
Published: February 2023

The article investigates an instance of responsive regulation as a team of inspectors conducts an unannounced raid. The raid takes place in Denmark and its aim is to judge and regulate tax compliance in a number of small businesses. The article argues that different ‘logics of generalization’ is at play as inspectors as well as business owners value the state-­of-­affairs in the businesses. Furthermore, the article discusses how the inspectors are responsive in the raid. It argues that they are responsive – not primarily towards the behaviour of the taxpayers – but towards a general public. The article hereby engages in the debate concerning what responsive regulation is and how it is played out in practice as the state regulates citizens and businesses. The overall analytical framework is inspired by Helen Verran’s notion of ‘relational empiricism’, and the analysis is an example of how this analytic can be used as a heuristic to analyze ethnographic data.
Évolution du rapport au savoir dans le parcours d’apprentissage de jeunes adultes en situation de précarité
Authors: Bélisle Rachel , Turmel Hélène , Bourdon Sylvain 
Published: February 2023

Cet article s’intéresse au parcours d’apprentissage de jeunes engagés dans leur passage à la vie adulte alors qu’ils sont exposés à la précarité. Nous mettons à l’épreuve le concept de rapport au savoir comme analyseur de leur parcours d’apprentissage dans un suivi longitudinal de quatre ou cinq ans. Ces jeunes sont rencontrés la première fois alors qu’ils ont entre 18 et 21 ans, qu’ils participent à un programme d’un organisme communautaire et qu’ils sont soutenus par l’aide financière de dernier recours de l’État. L’article montre qu’au fil du parcours les apprentissages lors de transitions sont d’abord réactifs et centrés sur la vie privée et qu’ils deviennent peu à peu plus proactifs orientés vers la vie publique et l’avenir.
Les milieux alternatifs de scolarisation au Québec : des stratégies adaptées aux parcours d’apprentissage des élèves en situation de vulnérabilité à la formation générale des adultes ?
Authors: Vidal Marjorie , Grossmann Sophie , Bourdon Sylvain 
Published: February 2023

Cet article porte sur le rôle joué par les milieux alternatifs de scolarisation (MAS) dans les parcours d’apprentissage des jeunes adultes au Québec. Les MAS sont des établissements qui accueillent et scolarisent des élèves de 16 ans et plus ayant interrompu leur parcours d’enseignement régulier et se trouvant en situation de vulnérabilité. La réflexion s’appuie sur des études de cas dans trois MAS: une école de la rue, une école privée et un organisme de raccrochage scolaire. Elle s’articule autour des stratégies mises en place par les acteurs et actrices des MAS. La trame narrative souligne en quoi certaines pratiques proximales d’accompagnement permettent de s’adapter aux parcours non linéaires des élèves, les distinguant des établissements classiques comme les centres d’éducation des adultes.
Cruise CAGE-17-3
Authors: Bünz Stefan 
Published: February 2023

The overall goal of cruise CAGE 17-3 is to collect seismic, multibeam and water column data in an area along the northern flank of the Bear island trough and on the W-Svalbard margin. The objectives associated with the overall goal are to better understand the occurrence of gas hydrates and fluid leakage, the source of the gas in these systems, and seafloor expressions of fluid seepage. In order to address these objectives we plan to carry out:
2D and 3D P-Cable seismic and ocean-bottom seismic acquisition over a complex leakage and source-to-sink plumbing system in the Leirdjupet Fault complex in the SW Barents Sea;Recovery of one of CAGE’s ocean floor observatory from the crater area at the northern flank of the Bear Island Trough;Repeat of P-Cable 3D seismic acquisition on the eastern segment of the Vestnesa Ridge for time-lapse seismic studies of fluid flow and gas hydrates dynamics;2D multi-channel seismic for reconnaissance and stratigraphic correlation in the Molloy Ridge area;Multibeam mapping to fill in gaps and improve resolution of existing data using the upgraded EM302 system on R/V Helmer Hanssen
The cruise may be known as: CAGE17_3
Construction and validation of a fatty acid metabolism-related gene signature for predicting prognosis and therapeutic response in patients with prostate cancer
Authors: Zhao Hongjun , Wu Tong , Luo Zehao , Huang Qinyao , Zhu Sihua , Li Chunling , Zhang Zubing , Zhang Jiahao , Zeng Jianwen , Zhang Yuying 
Published: February 2023

Background
Reprogramming of fatty acid metabolism is a newly-identified hallmark of malignancy. However, no studies have systematically investigated the fatty acid metabolism related-gene set in prostate cancer (PCa).

Methods
A cohort of 381 patients with gene expression and clinical data from The Cancer Genome Atlas was used as the training set, while another cohort of 90 patients with PCa from GEO (GSE70769) was used as the validation set. Differentially expressed fatty acid metabolism-related genes were subjected to least absolute shrinkage and selection operator (LASSO)-Cox regression to establish a fatty acid metabolism-related risk score. Associations between the risk score and clinical characteristics, immune cell infiltration, tumor mutation burden (TMB), tumor immune dysfunction and exclusion (TIDE) score, and response to chemotherapy were analyzed. Finally, the expression level of genes included in the model was validated using real-time PCR.

Results
A prognostic risk model based on five fatty acid metabolism related genes (ALDH1A1, CPT1B, CA2, CROT, and NUDT19) were constructed. Tumors with higher risk score were associated with larger tumor size, lymph node involvement, higher Gleason score, and poorer biochemical recurrence (BCR)-free survival. Furthermore, the high- and low-risk tumors exhibited distinct immune cell infiltration features and immune-related pathway activation. High-risk tumors were associated with favorable response to immunotherapy as indicated by high TMB and low TIDE score, but poor response to bicalutamide and docetaxel chemotherapy.

Conclusion
This study established a fatty acid metabolism-related gene signature which was predictive of BCR and response to chemotherapy and immunotherapy, providing a novel therapeutic biomarker for PCa.
Assessment of Two Plant-Based Materials as Alternative Attractant of Honeybees (Apis Mellifera adansonii) for Production of Honey and Other Hive Products in Awka, Nigeria
Authors: Chidi Mr. C. A. , Mogbo T. C. , Akunne C. E. 
Published: February 2023

Aim: Honey is the earliest sweetener human beings have found. The values of honey are too numerous, such as food source, raw material for industries and as symbol employed in therapeutic ceremonies, but it’s availability and supply through traditional honey hunting remain a major constraint to its production and supply. This Field trials assessed the efficacy of Aidan fruit (Tetrapleura tetraptera) extract and Pineapple juice as alternative baits of honeybees (Apis mellifera adansonii) for the production of honey and other hive products.
Study Design: Completely Randomized Design.
Place and Duration of Study: Honeybee Research Centre of the Department of Zoology, Nnamdi Azikiwe University, P.M.B.5025, Awka, Anambra State, Nigeria, between July 2020 and February, 2022.
Methodology: Phytochemical analyses of the two plant-based materials were conducted in the laboratory using standard scientific methods. A total of 9 hives divided into 3 treatment groups: A1-3; P1-3 and H1-3 were used for the study. All the experimental hives were installed at the apiary unit of the HRC and monitored daily until colonization occurred.
Data collected were subjected to Analysis of Variance (ANOVA) while sample means were separated using Duncan’s Multiple Range Test at 5% significant level (P = 0.05).
Results: The results revealed that the trial baits contained moderate (++) presence of terpenoids as phytochemical component responsible for attracting bees. The results revealed also that the hives treated with the trial baits recorded equal rates of colonization of 66.67% as against the control which recorded 100% respectively.
Conclusion: The results suggest that these two plant-based materials can serve as alternative attractants of honeybees in beekeeping for the production of honey and other hive products.
Impact of Optimizing Critical Care Resources in Pediatric Surgery Patients
Authors: Seiam Nora Mohammed , Nofal Ahmed Hassan , Harkan Ahmed Ibrahim , Muhammad Khaled Talaat 
Published: February 2023

Background: Prediction scores could help to timely identify patients at risk. More intense care monitoring outside the pediatric intensive care unit (PICU) could improve outcomes. These concepts of critical care without borders could be implemented shortly with local resources and improve patient safety. Predict more, do less in PICUs, and more in the ward. The aim of this work was to evaluate the impact of prediction scores for identification of postoperative high risk surgical patients and their need for pediatric intensive care unit admission.
Methods: This prospective study was carried out on 40 pediatric patients. The studied patients were divided into three groups. LR Group: 14 cases with ASA = 1, 2 PEWS ≤ 2, pSOFA ≤ 7, LqSOFA < 2. IR Group: 10 cases with PEWS = 3, 4 pSOFA = 8 -11 HiR Group: 16 cases with ASA = 3 -5, PEWS ≥ 5, pSOFA ≥ 12, LqSOFA ≥ 2. American Society of Anaesthesiologists (ASA) scoring was obtained from each patient preop. The Pediatric Early Warning (PEWS) Scoring was obtained from each patient immediately postop. The Pediatric Sequential Organ Failure Assessment (pSOFA) Scoring was obtained from patients admitted to PICU on day 1 and day 7. Liverpool quick Sequential Organ Failure Assessment (LqSOFA) scoring was obtained from all patients on admission.
Results: Regarding prognostic performance of different scores to predict mortality. For ASA score: it was statistically significant with AUC = .882, cut off values > 3, sensitivity = 75%, specificity = 88.89%, PPV = 42.9% and NPV = 97%. -For PEW score: it was statistically significant with AUC = .892, cut off values > 5, sensitivity = 79%, specificity = 80.56%, PPV =30% and NPV = 96.7%. -For pSOFA score: it was statistically significant with AUC = .931, cut off values > 14, sensitivity = 85%, specificity = 86.11%, PPV =37.5%, and NPV = 96.9%. All ASA, PEW, and pSOFA were statistically significant as univariate but none was significant as multivariate.
Conclusions: ASA score, pSOFA score and PEWS score were significant predictor to length of stay (>21 days). ASA score, PEW score and pSOFA score were significant as predictor to mortality. ASA score and PEWS score were highly significant as to predict PICU Admission postop. PEWS score was highly significant as to predict PICU Admission postop. ASA, PEWs, and pSOFA were predictors for LOS for more than 21 days, predictors of mortality and predictors for PICU admission Postop. Decreased platelets and increased WBCs, urea, creatinine, AST, and RBG were significant with HiR. LqSOFA is a simple variable bedside tool for identifying septic patients at high risk for poor outcomes.
Controlled Cascade‐Release and High Selective Sterilization by Core–Shell Nanogels for Microenvironment Regulation of Aerobic Vaginitis
Authors: Wang Xinxin , Wang Yiting , Tang Mengteng , Wang Xiaoyi , Xue Wei , Zhang Xiao , Wang Yuxia , Lee Wen‐Hui , Wang Yingshuai , Sun Tong‐Yi , Gao Yuanyuan , Li Li‐Li 
Published: February 2023

AbstractAerobic vaginitis (AV) is a gynecological disease associated with vaginal flora imbalance. The nonselective bactericidal nature of antibiotics and low customization rate of probiotic supplementation in existing treatments lead to AV recurrence. Here, a drug delivery strategy is proposed that works with the changing dynamics of the bacterial flora. In particular, a core–shell nanogel (CSNG) is designed to encapsulate prebiotic inulin and antimicrobial peptide Cath 30. The proposed strategy allows for the sequential release of both drugs using gelatinase produced by AV pathogenic bacteria, initially selectively killing pathogenic bacteria and subsequently promoting the proliferation of beneficial bacteria in the vagina. In a simulated infection environment in vitro, the outer layer of CSNGs, Cath 30 is rapidly degraded and potently killed the pathogenic bacterium Staphylococcus aureus at 2–6 h. CSNGs enhances proliferation of the beneficial bacterium Lactobacillus crispatus by more than 50% at 24 h. In a rat AV model, the drug delivery strategy precisely regulated the bacterial microenvironment while controlling the inflammatory response of the vaginal microenvironment. This new treatment approach, configured on demand and precisely controlled, offers a new strategy for the treatment of vaginal diseases.
Enhancing the Management of Metastatic Tumors by Robust Co‐Delivery of 5‐Fluorouracil/MicroRNA‐10b Inhibitor Using EGFR‐Targeted Nanovehicles
Authors: Wang Di , Wang Liwei , Zheng Liming , Chen Jiaxin , Zhang Wei , Zhou Wei , Yang Xiaobo , Jiang Lifeng , Jin Xiaoqiang , Yu Xiaohua , Liu Xin , Chen Heng , Xu Jianbin 
Published: February 2023

AbstractInvasion and metastasis are the leading causes of death of patients with CRC. 5‐Fluorouracil is widely used in clinic practice as the basic chemotherapy drug for CRC. However, it is inefficient in inhibiting tumor metastasis. MicroRNA‐10b is uninvolved in regulating the growth of primary tumors; however, it could induce early tumor metastases and is a key regulator of chemotherapeutic resistance to 5‐FU. A multifunctional nanovehicle that can carry small molecule drugs not only through the hydrophobic pockets of conjugated β‐cyclodextrin but also through electrostatic interaction between the conjugated peptides and siRNA to target functional genes is previously developed. In this study, a nanovehicle, named GCD, with epithelium growth factor receptor (EGFR)‐targeted characteristics to simultaneously deliver chemotherapeutic and nucleotide drugs to distinct targets in CRC, is employed. These data show that co‐delivery of 5‐FU and anti‐miR‐10b can be effectively applied to targeted therapy of EGFR‐overexpressed CRC, particularly inhibiting the metastasis of CRC. Furthermore, the therapeutic effect of this combination on tumor xenograft models derived from patients with CRC is evaluated. Taken together, this study may provide insights into the inhibition of tumor growth and metastasis simultaneously.
Tumor‐Targeting Near‐Infrared Dimeric Heptamethine Cyanine Photosensitizers with an Aromatic Diphenol Linker for Imaging‐Guided Cancer Phototherapy
Authors: Xu Yang , Yu Jiaying , Hu Jinzhong , Sun Kai , Lu Wenjun , Zeng Fenglian , chen Jian , liu Min , Cai Zhuoer , He Xiaofan , Wei Wanying , Sun Baiwang 
Published: February 2023

AbstractPhototherapy is considered a promising alternative to conventional tumor treatments due to its noninvasive modality and effective therapeutic effect. However, designing a photosensitizer with satisfactory therapeutic effect and high security remains a considerable challenge. Herein, a series of dimeric heptamethine cyanine photosensitizers with an aromatic diphenol linker at the meso position is developed to improve the photothermal conversion efficiency (PCE). Thanks to the extended conjugate system and high steric hindrance, the screened 26NA‐NIR and 44BP‐NIR exhibit high PCE (≈35%), bright near‐infrared (NIR) fluorescence, excellent reactive oxygen species (ROS) generation capability, and improved photostability. Furthermore, their outstanding performance on imaging‐guided PDT–PTT synergistic therapy is demonstrated by in vivo and in vitro experiments. In conclusion, this study designs a series of dimeric heptamethine cyanine photosensitizers and presents two compounds for potential clinical applications. The strategy provides a new method to design NIR photosensitizers for imaging‐guided cancer treatment.
Reversible Perspiring Artificial “Fingertips”
Authors: Zhang Dongyu , Peixoto Jacques , Zhan Yuanyuan , Astam Mert O. , Bus Tom , van der Tol Joost J. B. , Broer Dirk J. , Liu Danqing 
Published: February 2023

AbstractFingertip perspiration is a vital process within human predation, to which the species owes its survival and its biological success. In this paper, the unique human ability of extensive perspiration and controlled friction in self‐assembled cholesteric liquid crystals is recreated, mimicking the natural processes that occur in the dermis and epidermis of human skin. This is achieved by inducing porosity in responsive, liquid‐bearing material through the controlled‐polymerization phase‐separation process. The unique topography of human fingerprints is further emulated in the materials by balancing the parallel chirality‐induced force and the perpendicular substrate‐anchoring force during synthesis. As a result, artificial fingertips are capable of secreting and re‐absorbing liquid upon light illumination. By demonstrating the function of the soft material in a tribological aspect, it exhibits a controllable anti‐sliding property comparable to human fingertips and subsequently attains a higher degree of biomimicry. This biomimetic fingertip is envisioned being applied in a multitude of fields, ranging from biomedical instruments to interactive, human‐like soft robotic devices.