bluuebunny/crossref_metadata_2025_split huggingface dataset:
All‐in‐one whole exome sequencing strategy with simultaneous copy number variant, single nucleotide variant and absence‐of‐heterozygosity analysis in fetuses with structural ultrasound anomalies: A 1‐year experience
Authors: Faas Brigitte H. W. , Westra Dineke , de Munnik Sonja A. , van Rij Maartje , Marcelis Carlo , Joosten Sara , Krapels Ingrid , Vernimmen Vivian , Heijligers Malou , Willemsen Marjolein H. , de Leeuw Nicole , Rinne Tuula , Pfundt Rolph , Smeekens Sanne P. , Stegmann Sander P. A. , Macville Merryn , Sikkel Esther , Coumans Audrey , Wijnberger Lia , Derks Irma , van Lent‐Albrechts Josefa , Hofste Tom , Timmermans Raoul , van den End Janneke , Stevens Servi J. C. , Feenstra Ilse 
Published: January 2023

AbstractObjectiveWe performed a 1‐year evaluation of a novel strategy of simultaneously analyzing single nucleotide variants (SNVs), copy number variants (CNVs) and copy‐number‐neutral Absence‐of‐Heterozygosity from Whole Exome Sequencing (WES) data for prenatal diagnosis of fetuses with ultrasound (US) anomalies and a non‐causative QF‐PCR result.MethodsAfter invasive diagnostics, whole exome parent‐offspring trio‐sequencing with exome‐wide CNV analysis was performed in pregnancies with fetal US anomalies and a non‐causative QF‐PCR result (WES‐CNV). On request, additional SNV‐analysis, restricted to (the) requested gene panel(s) only (with the option of whole exome SNV‐analysis afterward) was performed simultaneously (WES‐CNV/SNV) or as rapid SNV‐re‐analysis, following a normal CNV analysis.ResultsIn total, 415 prenatal samples were included. Following a non‐causative QF‐PCR result, WES‐CNV analysis was initially requested for 74.3% of the chorionic villus (CV) samples and 45% of the amniotic fluid (AF) samples. In case WES‐CNV analysis did not reveal a causative aberration, SNV‐re‐analysis was requested in 41.7% of the CV samples and 17.5% of the AF samples. All initial analyses could be finished within 2 weeks after sampling. For SNV‐re‐analysis during pregnancy, turn‐around‐times (TATs) varied between one and 8 days.ConclusionWe show a highly efficient all‐in‐one WES‐based strategy, with short TATs, and the option of rapid SNV‐re‐analysis after a normal CNV result.
Prediction of quasi‐static elastic modulus for polyethylene‐terephthalate‐glycol prepared from fused deposition modeling
Authors: Cui Xinrui , Jar P.‐Y. Ben 
Published: January 2023

AbstractThis article is concerned about change of elastic modulus as a function of raster angle used in the fused deposition modeling and applicability of laminate theory to prediction of the elastic modulus. Polyethylene terephthalate glycol (PETG) was used for the experimental testing. In view that PETG shows viscous deformation which was not considered in the laminate theory, quasi‐static (QS) component of the elastic modulus was used to examine the applicability of laminate theory, which was achieved by extraction of the QS stress response to deformation through stress relaxation and then finite element modeling of the slope for the load–displacement curve before the relaxation. Two analytical approaches were used to examine the laminate theory. One was known as the mechanics of materials approach that considers matrix properties from the intralayer regions, and the other the elasticity model approach that also considers the interlayer regions. The study found that both approaches provided reasonable estimation of the QS elastic modulus but their values were slightly over the measured values. We provide evidence to suggest that the prediction accuracy could be improved by considering the change of interlayer filament contact with the change of raster angle.
Modeling the risk of acetone emission from a storage tank in summer and winter
Authors: Li Xi , Li Jian , Ji Wenjing , Ou Yangcui , He Ranran , Xu Xiaoguang , Wang Boliang 
Published: January 2023

AbstractThe leakage of acetone from damaged tanks can threaten workers, surrounding facilities, and the environment. The safe storage of acetone is of vital importance for emergency planning and response. This paper focused on the effects and consequences of acetone leaks from a 200 m3 storage tank in the summer and winter seasons by the employment of Areal Locations of Hazardous Atmospheres. The hazard zones classified as red threat zone, orange threat zone, and yellow threat zone were determined and analyzed. Results showed that the risk distribution of the toxic acetone vapor cloud in summer was greater than those in winter. The summer and winter seasons have no significant effect on the thermal radiation intensities from pool fire and the Boiling Liquid Expanding Vapor Explosion (BLEVE) scenario. The maximum distance of toxicity, flammability, and thermal radiation from the pool fire and BLEVE scenario for the acetone leakage were 547, 111, 16, and 1100 m, respectively. The results would provide guidance for decision‐makers in safety management and emergency response to reduce hazards.
A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models
Authors: Yau Estelle , Gertz Michael , Ogungbenro Kayode , Aarons Leon , Olivares‐Morales Andrés 
Published: January 2023

AbstractSimplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to in vivo pharmacokinetic (PK) data. After optimization with preclinical data, the performance of these models for extrapolation of distribution kinetics to human were evaluated to determine the best approach for the prediction of human drug disposition and volume of distribution (Vss) using PBPK modeling. Three lipophilic bases were tested (diazepam, midazolam, and basmisanil) for which intravenous PK data were available in rat, monkey, and human. The models with Kpu scalars using k‐means clustering were generally the best for fitting data in the preclinical species and gave plausible Kpu values. Extrapolations of plasma concentrations for diazepam and midazolam using these models and parameters obtained were consistent with the observed clinical data. For diazepam and midazolam, the human predictions of Vss after optimization in rats and monkeys were better compared with the Vss estimated from the traditional PBPK modeling approach (varying from 1.1 to 3.1 vs. 3.7‐fold error). For basmisanil, the sparse preclinical data available could have affected the model performance for fitting and the subsequent extrapolation to human. Overall, this work provides a rational strategy to predict human drug distribution using preclinical PK data within the PBPK modeling strategy.
Risk assessment validation in patients with pulmonary arterial hypertension: Data from a Southern Brazil registry (RESPHIRAR study)
Authors: Spilimbergo Fernanda Brum , Pirath Rodrigues Roger , Credidio Dias‐Pinto Marcelo , Blanco Daniela Cavalet , Barbieri Gláucia Maria , Andrade‐Lima Marina , Leal Fagundes Ariovaldo , Gazzana Marcelo Basso , Roncato Gabriela , Mello Marcelo Martins , Watte Guilherme , Assmann Taís Silveira , Caurio Cássia Ferreira Braz , Souza Rogerio , Meyer Gisela Martina Bohns 
Published: January 2023

AbstractPulmonary arterial hypertension (PAH) is a severe and progressive disease characterized by increased pulmonary vascular resistance, ultimately leading to right heart failure and death. Registries are a valuable tool in the research of rare conditions such as PAH. Moreover, the risk assessment strategy has been validated in European and North American registries and has been reported to provide an accurate prediction of mortality and the clinical advantage of reaching low‐risk status. However, there is no available data from Brazil. Thus, the aim of the present study was to describe the characteristics of a sample of PAH from Southern Brazil and to retrospectively validate the risk assessment at our population. The RESPHIRAR is a retrospective and multicentric registry on pulmonary hypertension. With a join collaboration from nine centers in Southern Brazil, demographics, clinical presentation, and hemodynamics data of PAH were collected between 2007 and 2017. Moreover, the REVEAL 2.0 and REVEAL 2.0 Lite risk assessments were validated in our population. Overall, 370 PAH patients were included in the present study. Patients were predominantly female (78.5%) and had a mean age of 41.8 ± 18.8 years. Most patients (33.4%) had idiopathic PAH, 30.2% had PAH associated with congenital heart disease, and 23.5% had PAH associated with connective tissue disease. The low‐risk group showed significantly lower mortality than the intermediated‐ or high‐risk group at diagnosis (p < 0.05). In conclusion, our data suggest that REVEAL 2.0 and REVEAL 2.0 Lite risk assessments can predict mortality risk in PAH patients in Southern Brazil.
Replacing cutting guides with an augmented reality‐based navigation system: A feasibility study in the maxillofacial region
Authors: Pietruski Piotr , Majak Marcin , Świątek‐Najwer Ewelina , Żuk Magdalena , Popek Michał , Świecka Marta , Jaworowski Janusz , Mazurek Maciej 
Published: January 2023

AbstractPurposeThe work presents outcomes of simulated maxillofacial skeleton osteotomies supported with cutting guides or one of two AR‐based intraoperative navigation systems.Material and MethodsThe series of osteotomies supported with a cutting guide, simple AR (sAR) or navigated AR (nAR) module were carried out on 15 (five per each method) skull models according to the virtual surgical plan (VSP). Each method was used to support 40 osteotomies involving the upper jaw and 40 involving the orbital region (16 osteotomies on each model). Postoperative computed tomography scans were fused with the VSP to analyse angular deviations from the planned cutting trajectory (°) and the deviations of labelled control points (mm).ResultsGuides provided the highest accuracy, with a mean osteotomy angular deviation of 3.73 ± 2.94° and a mean control point deviation of 1.30 ± 0.73 mm. Mean angular deviations for the sAR‐ and nAR‐assisted osteotomies were 5.93 ± 5.12° and 6.75 ± 5.33°, and mean control point deviations amounted to 1.86 ± 0.88 mm and 1.97 ± 0.70 mm.
The role of renewable energy investment in tackling climate change concerns: Environmental policies for achieving SDG‐13
Authors: He Xiuzhi , Khan Samiha , Ozturk Ilhan , Murshed Muntasir 
Published: January 2023

AbstractIn the contemporary era, tackling climate change‐related problems has become a vital environmental policy agenda, especially for realizing the targets related to SDG‐13. Therefore, this study aims to check the efficacy of scaling public investments in research and development for renewable energy development in countering the causes and effects of climate change in leading renewable energy‐investing countries. Overall, the findings verify the climate change‐inhibiting impact of such investments. By contrast, consumption of natural resources and urbanization are identified as factors responsible for piling up climate change‐related concerns in the long run while no impact of net exports, in this regard, is evidenced. Moreover, the long‐run results affirm that public investment in renewable energy development projects also exerts moderating effects for partially neutralizing the adverse climate change concerns associated with natural resource consumption and urbanization. Furthermore, such investments are also evidenced to mediate the repercussions of net exports on the causes and effects of climate change in the long run. Based on these key findings, it is recommended to scale budgetary allocations for financing renewable energy technology development‐oriented initiatives, enhancing the efficiency rate of natural resource utilization, and deploying environmentally sustainable urbanization policies for achieving the targets concerning objectives of SDG‐13.
Tourism poverty alleviation hotspots in China: Topic evolution and sustainable development
Authors: Wang Jinli , Lv Wanqing 
Published: January 2023

AbstractUnderstanding the hotspots and patterns of tourism poverty alleviation is of great significance to stakeholders. This study aims to comprehensively and scientifically understand the research hotspots, characteristics, trends, and future research directions in the field of tourism poverty alleviation, provide decision support for tourism stakeholders, improve the level of management and service quality of tourism, balance the distribution of tourism resources and interests, and promote high‐quality and sustainable development of tourism. First, we propose a dynamic nonnegative matrix factorization (DNMF) method to analyze the tourism poverty alleviation literature from 2012 to 2021, extract hot topics and topic words. Then, we propose a topic evaluation criteria to evaluate the effect of the extracted topics. Third, we propose a topic intensity model to calculate the intensity of hot topics that can track the evolution trend of hot topics in the past 10 years, and explore the future development trends of the tourism poverty alleviation. Finally, we put forward the countermeasures and suggestions for sustainable tourism poverty alleviation under the guidance of sustainable development theory. The experimental results show that DNMF has a good effect in topic extraction. The evolution process based on topic intensity reflects the evolution trend of China's tourism poverty alleviation. This study provides a theoretical foundations and technical support for the sustainable development of China's tourism poverty alleviation.
Sulfur polymerization strategy based on the intrinsic properties of polymers for advanced binder‐free and high‐sulfur‐content Li–S batteries
Authors: Song Zihui , Zhang Tianpeng , Liu Siyang , Shao Wenlong , Jiang Wanyuan , Mao Runyue , Jian Xigao , Hu Fangyuan 
Published: January 2023

AbstractLithium–sulfur (Li–S) batteries are the promising next‐generation secondary energy storage systems, because of their advantages of high energy density and environmental friendliness. Among numerous cathode materials, organosulfur polymer materials have received extensive attentions because of their controllable structure and uniform sulfur distribution. However, the sulfur content of most organosulfur polymer cathodes is limited (S content <60%) due to the addition of large amounts of conductive agents and binders, which adversely affects the energy density of Li–S batteries. Herein, a hyperbranched sulfur‐rich polymer based on modified polyethyleneimine (Ath‐PEI) named carbon nanotube‐entangled poly (allyl‐terminated hyperbranched ethyleneimine‐random‐sulfur) (CNT/Ath‐PEI@S) was prepared by sulfur polymerization and used as a Li–S battery cathode. The high intrinsic viscosity of Ath‐PEI provided considerable adhesion and avoided the addition of PVDF binder, thereby increasing the sulfur content of cathodes to 75%. Moreover, considering the uniform distribution of elemental sulfur by the polymer, the utilization of sulfur was successfully improved, thus improving the rate capability and discharge capacity of the battery. The binder‐free, sulfur‐rich polymer cathode exhibited ultra‐high initial discharge capacity (1520.7 mAh g−1 at 0.1 C), and high rate capability (804 mAh g−1 at 2.0 C). And cell‐level calculations show that the electrode exhibits an initial capacity of 942.3 mAh g−1electrode, which is much higher than those of conventional sulfur‐polymer electrodes reported in the literature.
Prevalence of adenomyosis in women with subfertility: systematic review and meta‐analysis
Authors: Mishra I. , Melo P. , Easter C. , Sephton V. , Dhillon‐Smith R. , Coomarasamy A. 
Published: January 2023

ABSTRACTObjectiveTo determine the prevalence of adenomyosis in women with subfertility.MethodsA systematic search was conducted in MEDLINE, EMBASE, CINAHL Plus, Google Scholar, PsycINFO and Web of Science Core Collection from database inception to October 2022. The included studies evaluated the prevalence of adenomyosis in women with subfertility, with or without endometriosis and/or uterine fibroids. Secondary analyses were conducted to identify variation in the prevalence of isolated adenomyosis according to geographical location, diagnostic modality, diagnostic criteria, type of ultrasound, ultrasound features of adenomyosis and the use of assisted reproductive technology.ResultsAmong 21 longitudinal studies evaluating 25 600 women, the overall pooled prevalence of isolated adenomyosis was 10% (95% CI, 6–15%) (I2 = 99.1%; tau2 = 0.12). The pooled prevalence was 1% (95% CI, 0–4%) for adenomyosis with concurrent fibroids (eight studies; I2 = 95.8%; tau2 = 0.03), 6% (95% CI, 3–11%) for adenomyosis with concurrent endometriosis (18 studies; I2 = 98.6%; tau2 = 0.12) and 7% (95% CI, 2–13%) for adenomyosis with concurrent endometriosis and/or fibroids (nine studies; I2 = 98.3%; tau2 = 0.09). The prevalence of isolated adenomyosis varied substantially according to geographical location, with Australia exhibiting the highest pooled prevalence of adenomyosis (19% (95% CI, 12–27%)), which was significantly higher compared with that in Asia (5% (95% CI, 1–12%)). The pooled prevalence of isolated adenomyosis diagnosed using a combination of direct and indirect ultrasound features was 11% (95% CI, 7–16%), whereas it was 0.45% (95% CI, 0–1%) in the study in which only an indirect feature was used as the diagnostic criterion.ConclusionOne in 10 women with subfertility have a diagnosis of isolated adenomyosis. The prevalence of adenomyosis varies according to the presence of concurrent endometriosis and/or fibroids. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Predicting spontaneous preterm birth in asymptomatic high‐risk women with cervical cerclage
Authors: Ridout A. E. , Ross G. , Seed P. T. , Hezelgrave N. L. , Tribe R. M. , Shennan A. H. 
Published: January 2023

ABSTRACTObjectiveTo determine the performance of the predictive markers of spontaneous preterm birth, cervicovaginal quantitative fetal fibronectin (fFN) and cervical length, in asymptomatic high‐risk women with transabdominal, history‐indicated or ultrasound‐indicated cervical cerclage.MethodsThis was a secondary analysis of a prospective cohort of asymptomatic high‐risk women with cervical cerclage and no other prophylactic intervention (including progesterone), who attended the preterm birth clinic at a central London teaching hospital between October 2010 and September 2016. Women had either transabdominal cerclage, placed prior to conception, history‐indicated cerclage, placed before 14 weeks' gestation, or ultrasound‐indicated cerclage for a short cervix (< 25 mm), placed before 24 weeks. All women underwent serial cervical length assessment on transvaginal ultrasound in the second trimester (16–28 weeks), and quantitative fFN testing from 18 weeks onward. Test performance was analyzed for the prediction of spontaneous preterm birth before 30 weeks (cerclage failure), 34 weeks and 37 weeks, using receiver‐operating‐characteristics (ROC)‐curve analysis.ResultsOverall, 181 women were included in the analysis. Cervical length and fFN were strong predictors of spontaneous preterm birth before 30 weeks in women with cerclage, with areas under the ROC curve (AUC) of 0.86 (95% CI, 0.79–0.94) and 0.84 (95% CI, 0.75–0.92), respectively. Cervical length was a better predictor of preterm birth before 30 weeks in women with history‐indicated compared to those with ultrasound‐indicated cerclage, although both showed clinical utility (AUC, 0.96 (95% CI, 0.91–1.00) vs 0.79 (95% CI, 0.66–0.91); P = 0.01). Quantitative fFN was a strong predictor of spontaneous preterm birth before 30 weeks in women with history‐indicated cerclage (AUC, 0.91 (95% CI, 0.75–1.00)) and retained clinical utility in those with ultrasound‐indicated cerclage (AUC, 0.76 (95% CI, 0.64–0.89)). There were no spontaneous deliveries before 34 weeks in women with a transabdominal cerclage, so AUC was not calculated. Delivery was delayed significantly in this group (P < 0.01).ConclusionsCervical length and quantitative fFN retain clinical utility for the prediction of spontaneous preterm birth in women with cervical cerclage, and prediction is best in women with a history‐indicated stitch. These tests can be relied upon to discriminate risk and have utility when planning clinical management with regard to treatment failure. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Algorithms for Large-Scale Network Analysis and the NetworKit Toolkit
Authors: Angriman Eugenio , van der Grinten Alexander , Hamann Michael , Meyerhenke Henning , Penschuck Manuel 
Published: January 2023

AbstractThe abundance of massive network data in a plethora of applications makes scalable analysis algorithms and software tools necessary to generate knowledge from such data in reasonable time. Addressing scalability as well as other requirements such as good usability and a rich feature set, the open-source software NetworKit has established itself as a popular tool for large-scale network analysis. This chapter provides a brief overview of the contributions to NetworKit made by the SPP 1736. Algorithmic contributions in the areas of centrality computations, community detection, and sparsification are in the focus, but we also mention several other aspects – such as current software engineering principles of the project and ways to visualize network data within a NetworKit-based workflow.
Algorithms for Big Data Problems in de Novo Genome Assembly
Authors: Srivastav Anand , Wedemeyer Axel , Schielke Christian , Schiemann Jan 
Published: January 2023

AbstractDe novo genome assembly is a fundamental task in life sciences. It is mostly a typical big data problem with sometimes billions of reads, a big puzzle in which the genome is hidden. Memory and time efficient algorithms are sought, preferably to run even on desktops in labs. In this chapter we address some algorithmic problems related to genome assembly. We first present an algorithm which heavily reduces the size of input data, but with no essential compromize on the assembly quality. In such and many other algorithms in bioinformatics the counting of k-mers is a botleneck. We discuss counting in external memory. The construction of large parts of the genome, called contigs, can be modelled as the longest path problem or the Euler tour problem in some graphs build on reads or k-mers. We present a linear time streaming algorithm for constructing long paths in undirected graphs, and a streaming algorithm for the Euler tour problem with optimal one-pass complexity.
Kinetically stabilized inflation
Authors: Li Changhong , Gong Hao , Cheung Yeuk-kwan Edna 
Published: January 2023

Abstract
In this work, we propose a string-inspired two fields inflation model to address the fine-tuning problem that the standard inflation model suffers. The fast-rolling tachyon $$ \mathcal{T} $$
T
originated from the D-brane and anti-D-brane pair annihilation locks the inflaton φ slowly rolling on a Higgs-like potential $$ V\left(\varphi \right)=-{m}_{\varphi}^2{\varphi}^2+\lambda {\varphi}^4 $$
V

φ

=
−

m
φ
2

φ
2

+
λ

φ
4

and drives a kinetically stabilized (KS) inflation. Our numerical simulation confirms such a solution is a dynamic attractor. In particular, for λ < 0.8 × 10−3, the e-folding number contributed by the KS inflation phase can be larger than 62 to solve the horizon and flatness problems of Big Bang theory. Notably, this KS inflation generates a nearly scale-invariant primordial curvature perturbations spectrum consistent with current cosmic microwave background (CMB) observations. It predicts a low tensor-to-scalar ratio, which the current primordial gravitational wave background (the B-modes in CMB) searches favor.