bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensory Mapping of UHT Milk with Single-Origin Chocolate
Authors: Hunaefi Dase , Tarigan Sures Setiadi , Dwinawati Elisabeth , Sholehuddin Zen Fauzan , Taqi Fahim Muchammad , Zeller Yves Henri Marie 
Published: June 2023

Like coffee, the popularity of speciality chocolate flavour or single-origin chocolate is growing in the Indonesian market. At the same time, sensory characteristic of the chocolate flavors is becoming more important, affecting both the taste and marketing of food product with chocolate flavor. As such, this study aims to describe UHT milk with single-origin chocolate through a complete sensory attribute mapping. A focus group discussion (FGD) resulted 15 texture attributes, 11 need-state attributes, 15 music attributes, 17 emotion attributes, 11 flavor attributes, and additional 70 color attributes. The complete sensory mapping test was performed using the CATA method based on attributes obtained from the FGD and analyzed using XLSTAT. The resulting product descriptions are as follows: cocoa Flores products were associated with soft and light textures, a need to focus and provide energy, pleasant classical and pop music, relaxed and warm emotions, flavors of ice cream, and light green, purple and brown colors. Cocoa Bali was linked to a smooth but rather hard texture, a need for rest and exercise, a cheerful musical style, happy emotions, a biscuit flavor, and a pink-yellow color. Cocoa Aceh was correlated with smooth and soft textures, state-of-the-art rest, energetic music, relaxed and energetic emotions, creamy flavor, and blue color. Meanwhile, cocoa Java was attributed with a smooth but rather hard texture, a state-of-the-art mood booster, cheerful music, relaxed emotions, ice cream flavor, and red-brown color. Thus, understanding specific sensory characteristics enables the producer to improve the product's development and marketing.
Potensi Ekstrak Kulit Daun Lidah Buaya sebagai Bahan Antibakteri pada Active Film Berbasis Pektin
Authors: Sobarsa Herza Govina , Suyatma Nugraha Edhi , Kusumaningrum Harsi Dewantari 
Published: June 2023

Edible film is a thin layer made of materials that can be consumed, protect from moisture and gas, and extend the shelf life of food products. The criteria for the materials for edible films are able to withstand gas and water permeation, colorless, do not cause changes in the characteristics of the packaged food products, and are safe for consumption. One of the ingredients that can be added to edible film is Aloe vera skin. The study aimed to determine the effect of increasing the aloe vera leaf extract concentration and producing an antibacterial edible film with the appropriate mechanical and antibacterial inhibitory properties. The study used a completely randomized design. Observations of film’s characteristics included mechanical and physical properties i.e., tensile strength, elongation, modulus of elasticity, water vapor transmission rate, thickness, CIE color values, and the inhibition activity of bacterial growth. The obtained data were analyzed using analysis of variance (ANOVA), and if there was a significant difference, Duncan’s Multiple Range Test was applied. The best edible film was obtained by adding aloe vera skin extract at a concentration of 4 times the Minimum Inhibitory Concentration (MIC). This film had a tensile strength of 0.878 MPa, elongation of 75.56%, modulus of elasticity of 1.16 MPa, thickness of 0.153 mm, Water Vapour Transmission Rate (WVTR) of 22.53 g/(m2.day), inhibition activity of 31.85 mm, and color value CIE ∆L* = 18.61, ∆a* = 0.98, ∆b* = 29.57, ∆E* = 38.63, ∆C*= 33.59, and ∆H* = -87.23 with the white plate color of chromameter used as a standard.
Potential drug-drug interactions and their associated factors in hospitalized COVID-19 patients with comorbidities
Authors: Rahmadani Imanda Dyah , Irawati Sylvi , Wibowo Yosi Irawati , Setiadi Adji Prayitno 
Published: June 2023

Background
Hospitalized COVID-19 patients with comorbidities receive more complex drug therapy. This increases the probability of potential drug-drug interactions (pDDIs). Studies on pDDIs in hospitalized patients with COVID-19 in countries with limited resources like Indonesia during the later period of the disease are still limited. This study aims to identify the pattern of pDDIs in hospitalized COVID-19 patients with comorbidities and their associated factors, especially in the second wave of the disease in Indonesia.

Methods
This study was a longitudinal-retrospective study observing hospitalized COVID-19 patients with comorbidities using medical record data in June–August 2021 at a public hospital in a region in Indonesia. pDDIs were identified using the Lexicomp® database. Data were descriptively analyzed. Factors associated with important pDDIs were analyzed in multivariate logistic regression model.

Results
A total of 258 patients with a mean age of 56.99 ± 11.94 years met the inclusion criteria. Diabetes mellitus was the most common comorbidity experienced by 58.14% of the patients. More than 70% of the patients had one comorbidity and the average number of administered drugs was 9.55 ± 2.71 items per patient. Type D pDDIs, which required modification of therapeutic regimens, amounted to 21.55% of the total interactions. Only the number of drugs was significantly and independently associated with type D pDDIs (adjusted odds ratio 1.47 [1.23–1.75], p < 0.01).

Conclusion
The drugs involved in the pDDIs of hospitalized COVID-19 patients with comorbidities may differ depending on the disease periods, hospital settings, or countries. This study was small, single center, and of short duration. However, it may give a glimpse of important pDDIs during the delta variant of COVID-19 in a similar limited-resource setting. Further studies are needed to confirm the clinical significance of these pDDIs.
Herbicide Sales in Groundnut Farming: an Analysis of Farmer and Dealer Buying Behavior in Rajkot District, India
Authors: Kiyada R. G. , Prajapati M. R. 
Published: June 2023

The world population is increasing and to meet the demands of population, a major increase in food production, trade, and agricultural activities will be required. Weeds cause more crop losses than pests and diseases together. It is responsible for more than 45% of all agricultural output losses. To tackle this problem herbicides are substances used to eradicate undesirable plants that could hinder crop growth and productivity. Weed competition reduced groundnut pod yield. So, for this reason, it is required to study buying pattern of farmers for herbicides used, factors affecting farmers during purchase of herbicides and factors affecting dealers with respect to herbicides.
The research design was a descriptive type. Non-probability sampling method and purposive sampling technique were used. To accomplish the objectives of the study primary data were collected from 120 farmers and 80 dealers from Rajkot, Gondal, Jetpur and Jasdan talukas of the Rajkot district. Study reveal that the majority of farmers belong to the thirty-five to fifty years age group, having below SSC level education and one to five lakh annual income. Most of the farmers live in a joint family having three to five members in their family. The majority of farmers belong to the semi-medium size of land holding and four to eight acres of land under groundnut cultivation with more than fifteen years of farming experience used herbicides ten to twenty years and used only post-emergence herbicides. Most farmers used Targa super, Shaked and Patela herbicides. Based on dealer recommendations majorly farmers purchase herbicides and applied two sprays with less than ₹1000 cost per acre. Major factors affecting to the farmers during the purchase of herbicides were a performance of product, brand name and dealer suggestions while major factors affecting to the dealers with respect to herbicides are past experience, brand image and margin.
Laser Resection of a Peripheral Giant Cell Granuloma in a 12 Year Old Boy: A Case Report
Authors: Aboujaoude Samia , Khalaf Roula Dib , Moukarzel Carla , Aoun Georges 
Published: June 2023

Peripheral giant cell granuloma is the most common non-neoplastic lesion that arises from the gingiva or alveolar mucosa. Although its etiology remains unclear, it is believed to be a reactive gingival overgrowth in response to local irritation, chronic trauma, or hormonal imbalance. In this report, we discuss the case of a 12-year-old male patient who presented with complaint of chewing difficulties due to gingival growth. The diagnosis of peripheral giant cell granuloma was made based on clinical and histopathological examinations. The lesion was removed with a diode laser in a chairside procedure.
Improvements in Physical Function and Pain Interference and Changes in Mental Health Among Patients Seeking Musculoskeletal Care
Authors: Zhang Wei , Singh Som P. , Clement Amdiel , Calfee Ryan P. , Bijsterbosch Janine D. , Cheng Abby L. 
Published: June 2023

ImportanceAmong patients seeking care for musculoskeletal conditions, there is mixed evidence regarding whether traditional, structure-based care is associated with improvement in patients’ mental health.ObjectiveTo determine whether improvements in physical function and pain interference are associated with meaningful improvements in anxiety and depression symptoms among patients seeking musculoskeletal care.Design, Setting, and ParticipantsThis cohort study included adult patients treated by an orthopedic department of a tertiary care US academic medical center from June 22, 2015, to February 9, 2022. Eligible participants presented between 4 and 6 times during the study period for 1 or more musculoskeletal conditions and completed Patient-Reported Outcomes Measurement Information System (PROMIS) measures as standard care at each visit.ExposurePROMIS Physical Function and Pain Interference scores.Main Outcomes and MeasuresLinear mixed effects models were used to determine whether improvements in PROMIS Anxiety and PROMIS Depression scores were associated with improved PROMIS Physical Function or Pain Interference scores after controlling for age, gender, race, and PROMIS Depression (for the anxiety model) or PROMIS Anxiety (for the depression model). Clinically meaningful improvement was defined as 3.0 points or more for PROMIS Anxiety and 3.2 points or more for PROMIS Depression.ResultsAmong 11 236 patients (mean [SD] age, 57 [16] years), 7218 (64.2%) were women; 120 (1.1%) were Asian, 1288 (11.5%) were Black, and 9706 (86.4%) were White. Improvements in physical function (β = −0.14; 95% CI, −0.15 to −0.13; P &amp;lt; .001) and pain interference (β = 0.26; 95% CI, 0.25 to 0.26; P &amp;lt; .001) were each associated with improved anxiety symptoms. To reach a clinically meaningful improvement in anxiety symptoms, an improvement of 21 PROMIS points or more (95% CI, 20-23 points) on Physical Function or 12 points or more (95% CI, 12-12 points) on Pain Interference would be required. Improvements in physical function (β = −0.05; 95% CI, −0.06 to −0.04; P &amp;lt; .001) and pain interference (β = 0.04; 95% CI, 0.04 to 0.05; P &amp;lt; .001) were not associated with meaningfully improved depression symptoms.Conclusions and RelevanceIn this cohort study, substantial improvements in physical function and pain interference were required for association with any clinically meaningful improvement in anxiety symptoms, and were not associated with any meaningful improvement in depression symptoms. Patients seeking musculoskeletal care clinicians providing treatment cannot assume that addressing physical health will result in improved symptoms of depression or potentially even sufficiently improved symptoms of anxiety.
Self‐Aggregated Nanoscale Metal–Organic Framework for Targeted Pulmonary Decorporation of Uranium
Authors: Chen Lei , Wang Xiaomei , Chen Mengping , Sun Qiwen , Chen Yemeng , Zhang Xiaojie , Hong Rui , Xu Yigong , Guan Jingwen , Hong Sheng , Cao Dehan , Sun Tingfeng , Li Ximeng , Chen Lanhua , Diwu Juan 
Published: June 2023

AbstractThe limited availability of effective agents for removing actinides from the lungs significantly restricts the effectiveness of medical treatments for nuclear emergencies. Inhalation is the primary route of internal contamination in 44.3% of actinide‐related accidents, leading to the accumulation of radionuclides in the lungs and resulting in infections and potential tumor formation (tumorigenesis). This study focuses on the synthesis of a nanometal−organic framework (nMOF) material called ZIF‐71‐COOH, which is achieved by post‐synthetic carboxyl functionalization of ZIF‐71. The material demonstrates high and selective adsorption of uranyl, while also exhibiting increased particle size (≈2100 nm) when it aggregates in the blood, enabling passive targeting of the lungs through mechanical filtration. This unique property facilitates the rapid enrichment and selective recognition of uranyl, making nano ZIF‐71‐COOH highly effective in removing uranyl from the lungs. The findings of this study highlight the potential of self‐aggregated nMOFs as a promising drug delivery system for targeted uranium decorporation in the lungs.
Doxorubicin‐Loaded Microrobots for Targeted Drug Delivery and Anticancer Therapy
Authors: Mallick Sudipta , Abouomar Ramadan , Rivas David , Sokolich Max , Kirmizitas Fatma Ceren , Dutta Aditya , Das Sambeeta 
Published: June 2023

AbstractMicro‐sized magnetic particles (also known as microrobots [MRs]) have recently been shown to have potential applications for numerous biomedical applications like drug delivery, microengineering, and single cell manipulation. Interdisciplinary studies have demonstrated the ability of these tiny particles to actuate under the action of a controlled magnetic field that not only drive MRs in a desired trajectory but also precisely deliver therapeutic payload to the target site. Additionally, optimal concentrations of therapeutic molecules can also be delivered to the desired site which is cost‐effective and safe especially in scenarios where drug dose‐related side effects are a concern. In this study, MRs are used to deliver anticancer drugs (doxorubicin) to cancer cells and subsequent cell death is evaluated in different cell lines (liver, prostate, and ovarian cancer cells). Cytocompatibility studies show that MRs are well‐tolerated and internalized by cancer cells. Doxorubicin (DOX) is chemically conjugated with MRs (DOX‐MRs) and magnetically steered toward cancer cells using the magnetic controller. Time‐lapsed video shows that cells shrink and eventually die when MRs are internalized by cells. Taken together, this study confirms that microrobots are promising couriers for targeted delivery of therapeutic biomolecules for cancer therapy and other non‐invasive procedures that require precise control.
Dual‐Responsive Turn‐On T1 Imaging‐Guided Mild Photothermia for Precise Apoptotic Cancer Therapy
Authors: Song Sijie , Wang Qi , Xie Jiangao , Dai Junduan , Ouyang Dilan , Huang Guoming , Guo Yuheng , Chen Chen , Wu Mengnan , Huang Tingjing , Ruan Jingwen , Cheng Xiaofeng , Lin Xucong , He Yu , Rozhkova Elena A. , Chen Zhaowei , Yang Huanghao 
Published: June 2023

AbstractApoptosis has gained increasing attention in cancer therapy as an intrinsic signaling pathway, which leads to minimal leakage of waste products from a dying cell to neighboring normal cells. Among various stimuli to trigger apoptosis, mild hyperthermia is attractive but confronts limitations of non‐specific heating and acquired resistance from elevated expression of heat shock proteins. Here, a dual‐stimulation activated turn‐on T1 imaging‐based nanoparticulate system (DAS) is developed for mild photothermia (≈43 °C)‐mediated precise apoptotic cancer therapy. In the DAS, a superparamagnetic quencher (ferroferric oxide nanoparticles, Fe3O4 NPs) and a paramagnetic enhancer (Gd‐DOTA complexes) are connected via the N6‐methyladenine (m6A)‐caged, Zn2+‐dependent DNAzyme molecular device. The substrate strand of the DNAzyme contains one segment of Gd‐DOTA complex‐labeled sequence and another one of HSP70 antisense oligonucleotide. When the DAS is taken up by cancer cells, overexpressed fat mass and obesity‐associated protein (FTO) specifically demethylates the m6A group, thereby activating DNAzymes to cleave the substrate strand and simultaneously releasing Gd‐DOTA complex‐labeled oligonucleotides. The restored T1 signal from the liberated Gd‐DOTA complexes lights up the tumor to guide the location and time of deploying 808 nm laser irradiation. Afterward, locally generated mild photothermia works in concert with HSP70 antisense oligonucleotides to promote apoptosis of tumor cells. This highly integrated design provides an alternative strategy for mild hyperthermia‐mediated precise apoptotic cancer therapy.
Closed‐Loop Error‐Correction Learning Accelerates Experimental Discovery of Thermoelectric Materials
Authors: Choubisa Hitarth , Haque Md Azimul , Zhu Tong , Zeng Lewei , Vafaie Maral , Baran Derya , Sargent Edward H. 
Published: June 2023

AbstractThe exploration of thermoelectric materials is challenging considering the large materials space, combined with added exponential degrees of freedom coming from doping and the diversity of synthetic pathways. Here, historical data is incorporated, and is updated using experimental feedback by employing error‐correction learning (ECL). This is achieved by learning from prior datasets and then adapting the model to differences in synthesis and characterization that are otherwise difficult to parameterize. This strategy is thus applied to discovering thermoelectric materials, where synthesis is prioritized at temperatures <300 °C. A previously unexplored chemical family of thermoelectric materials, PbSe:SnSb, is documented, finding that the best candidate in this chemical family, 2 wt% SnSb doped PbSe, exhibits a power factor more than 2× that of PbSe. The investigations herein reveal that a closed‐loop experimentation strategy reduces the required number of experiments to find an optimized material by a factor as high as 3× compared to high‐throughput searches powered by state‐of‐the‐art machine‐learning (ML) models. It is also observed that this improvement is dependent on the accuracy of the ML model in a manner that exhibits diminishing returns: once a certain accuracy is reached, factors that are instead associated with experimental pathways begin to dominate trends.
Suppressing Structural Relaxation in Nanoscale Antimony to Enable Ultralow‐Drift Phase‐Change Memory Applications
Authors: Chen Bin , Wang Xue‐Peng , Jiao Fangying , Ning Long , Huang Jiaen , Xie Jiatao , Zhang Shengbai , Li Xian‐Bin , Rao Feng 
Published: June 2023

AbstractPhase‐change random‐access memory (PCRAM) devices suffer from pronounced resistance drift originating from considerable structural relaxation of phase‐change materials (PCMs), which hinders current developments of high‐capacity memory and high‐parallelism computing that both need reliable multibit programming. This work realizes that compositional simplification and geometrical miniaturization of traditional GeSbTe‐like PCMs are feasible routes to suppress relaxation. While to date, the aging mechanisms of the simplest PCM, Sb, at nanoscale, have not yet been unveiled. Here, this work demonstrates that in an optimal thickness of only 4 nm, the thin Sb film can enable a precise multilevel programming with ultralow resistance drift coefficients, in a regime of ≈10−4–10−3. This advancement is mainly owed to the slightly changed Peierls distortion in Sb and the less‐distorted octahedral‐like atomic configurations across the Sb/SiO2 interfaces. This work highlights a new indispensable approach, interfacial regulation of nanoscale PCMs, for pursuing ultimately reliable resistance control in aggressively‐miniaturized PCRAM devices, to boost the storage and computing efficiencies substantially.
Bifunctional MXene‐Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration
Authors: Tang Zhimin , Liu Yan , Xiang Huijing , Dai Xinyue , Huang Xiaolin , Ju Yahan , Ni Ni , Huang Rui , Gao Huiqin , Zhang Jing , Fan Xianqun , Su Yun , Chen Yu , Gu Ping 
Published: June 2023

AbstractRetinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this process is compromised by the imprecise neurogenic differentiation of RPCs and undermining function of transplanted cells surrounded by severely oxidative retinal lesions. Here, it is shown that ultrathin niobium carbide (Nb2C) MXene enables performance enhancement of RPCs for retinal regeneration. Nb2C MXene with moderate photothermal effect markedly improves retinal neuronal differentiation of RPCs by activating intracellular signaling, in addition to the highly effective RPC protection by scavenging free radicals concurrently, which has been solidly evidenced by the comprehensive biomedical assessments and theoretical calculations. A dramatically increased neuronal differentiation is observed upon subretinal transplantation of MXene‐assisted RPCs into the typical retinal degeneration 10 (rd10) mice, thereby contributing to the efficient restoration of retinal architecture and visual function. The dual‐intrinsic function of MXene synergistically aids RPC transplantation, which represents an intriguing paradigm in vision‐restoration research filed, and will broaden the multifunctionality horizon of nanomedicine.
Janus Functionalized Boron‐Nitride Nanosystems as a Potential Application for Absorber Layer in Solar Cells
Authors: Roondhe Basant , Roondhe Vaishali , Shukla Alok , Shukla Shobha , Luo Wei , Ahuja Rajeev , Saxena Sumit 
Published: June 2023

AbstractJanus nanosystems enable one to achieve complementary properties in a single entity. In the current study, the fundamental properties like structural, electronic, and dynamical of Janus hexagonal boron nitride (h‐BN) by selectively hydrogenating and fluorinating a h‐BN surface are systematically examined, using density functional theory. Functionalization of h‐BN introduces partial sp3 (buckled) character in the predicted materials as compared to planar sp2 h‐BNs. Fully fluorinated and hydrogenated h‐BN have a direct bandgap of 3.42 and 3.37 eV, respectively. All the investigated configurations are predicted to be dynamically stable. Furthermore, optical properties including dielectric function, absorption spectra, refractive index, and reflectivity are evaluated to realize the optical and photocatalytic behavior of considered systems. The dielectric function ɛ2(ω) shows fundamental absorption edge arising at 3.2, 3.9, 2.8, and 3.4 eV for hydrogen on boron and nitrogen, hydrogen on boron and fluorine on nitrogen, fluorine on boron and hydrogen on nitrogen (FBNH) and fluorine on boron and nitrogen which is comparable to the bandgap of respective monolayers. Solar cell parameters of all considered BN structures are calculated using the Shockley–Queisser (SQ) limit. The highest short‐circuit current density (Jsc
) for FBNH is found to be 2.1 mA cm−2 providing the efficiency of 8.27% making FBNH a potential candidate for absorber layer in solar cells.