bluuebunny/crossref_metadata_2025_split huggingface dataset:
An active clamp coupled inductor‐based soft‐switched quadratic boost converter
Authors: Upadhyay Prashant , Sharma Preeti , Khandelwal Subodh , Kumar Rajneesh , Hassanpour Sara 
Published: December 2022

SummaryThis paper proposes a novel active clamp‐based quadratic boost converter to achieve a high gain output voltage. The converter combines a quadratic boost converter with a voltage doubler circuit using a coupled inductor. An active clamp circuit with an auxiliary switch is used to utilize the usually wasted energy of leakage inductance and clamp the voltage to a certain limit. The combination of leakage inductance and parasitic capacitance of the main switch provides the benefit of zero voltage switching (ZVS) in both MOSFETs. Similarly, output diodes operating under zero current switching (ZCS) improve the overall efficiency of the converter. Voltage doubler and active clamp circuitry reduce the voltage stress on solid‐state devices; hence, a low Rds,ondevice is selected. The converter model is simulated using PSIM software and calculated maximum efficiency of ~95% for 200 W and measured maximum efficiency of ~93% for 190 W power level including various parasitic elements.
Design and analysis of single and multi‐input multioutput triple‐band metamaterial inspired antennas for WiMAX, WLAN, and satellite applications
Authors: El Yassini Abdessalam , Ibnyaich Saida , Nguyen Truong Khang , Zeroual Abdelouhab 
Published: December 2022

SummaryThis work proposes an electrical compact triple‐bands antenna founded on a composite left‐/right‐handed approach. This structure contains a rectangular patch combined with two unit cells based on the metamaterial properties that are used to produce wide electrical lengths in miniature physical sizes. Thus, the presented antenna is designed with a lower resonant frequency and miniature physical dimensions compared to conventional antennas. The suggested antenna has been produced on top of the FR4 substrate having tan δ = 0.022, εr = 4.58, and a size of 28 × 16 × 1.6 mm3. This structure provides three bandwidths of (2.391–2.54 GHz), (3.42–3.56 GHz), and (5.02–11.40 GHz). Additionally, a multi‐input multioutput (MIMO) antenna is designed by placing two similar radiating patches in a perpendicular shape. Therefore, this design approach has been used to achieve an important isolation among ports and less than −30 dB at frequency bands. The results of radiation patterns, envelope correlation coefficient, diversity gain, and channel capacity loss are below to 0.06, 10 dB, and 0.4 b/s/Hz respectively, which confirms that the MIMO antenna is compatible with wireless MIMO devices. These antennas have been modeled and experimentally confirmed, and the results have proven that the suggested antennas are useable and can support multi‐standard wireless applications.
Optimizing cCOG, a Web‐based tool, to detect dementia with Lewy Bodies
Authors: van Gils Aniek M. , van de Beek Marleen , van Unnik Annemartijn A. J. M. , Tolonen Antti , Handgraaf Dédé , van Leeuwenstijn Mardou , Lötjönen Jyrki , van der Flier Wiesje M. , Lemstra Afina , Rhodius‐Meester Hanneke F. M. 
Published: December 2022

AbstractIntroductionDistinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease (AD) is challenging due to overlapping presentations. We adapted a Web‐based test tool, cCOG, by adding a visuospatial task and a brief clinical survey and assessed its ability to differentiate between DLB and AD.MethodsWe included 110 patients (n= 30 DLB,n= 32 AD dementia, andn= 48 controls with subjective cognitive decline (SCD)). Full cCOG comprises six cognitive subtasks and a survey addressing self‐reported DLB core and autonomic features. First, we compared cCOG cognitive tasks to traditional neuropsychological tasks for all diagnostic groups and clinical questions to validated assessments of clinical features in DLB only. Then, we studied the performance of cCOG cognitive tasks and clinical questions, separately and combined, in differentiating diagnostic groups.ResultscCOG cognitive tasks and clinical survey had moderate to strong correlations to standard neuropsychological testing (.61≤rs≤ .77) and to validated assessments of clinical features (.41≤rs≤ .65), except for fluctuations and REM‐sleep behavior disorder (RBD) (rs= .32 andrs= .10). Full cCOG, including both cognitive tasks and brief survey had a diagnostic accuracy (acc) of 0.82 [95% CI 0.73–0.89], with good discrimination of DLB versus AD (acc 0.87 [0.76–0.95]) and DLB versus controls (acc 0.94 [0.86–0.98]).ConclusionWe illustrated that cCOG aids in distinguishing DLB and AD patients by using remote assessment of cognition and clinical features. Our findings pave the way to a funneled, harmonized diagnostic process among memory clinics and, eventually, a more timely and accurate diagnosis of DLB and AD.
Phylogeography of the endangered “eyed” turtles (genus Sacalia) and the discovery of a lineage derived from natural interspecific hybridization
Authors: Lin Liu , Chen Huai‐Qing , Gaillard Daniel , Shi Hai‐Tao , Luo Shu‐Jin 
Published: December 2022

AbstractThe herpetofauna of the Indomalayan bioregion of Asia suffers from severe habitat loss, unsustainable harvesting, and lack of research and conservation. Here, we investigated the range‐wide phylogeography of the endangered “eyed” turtles (genus Sacalia, including the Beale's Eyed Turtle S. bealei and the Four‐eyed Turtle S. quadriocellata) and discovered a natural interspecific hybrid turtle population in China. Based on phylogeny of the mitochondrial Cytochrome b gene of 101 samples in this study and public data, three major clades and six subclades were identified: S. bealei (SBE) in eastern‐southern China, east S. quadriocellata in South China (northern east [SQUen] and southern east [SQUes] subclades), and west S. quadriocellata mainly in Vietnam (northern west [SQUwn], central west [SQUwc], and southern west [SQUws] subclades). We sequenced 16 nuclear DNA loci of 87 samples from SBE, SQUen, SQUes, and SQUwn subclades. Population genetic clustering analysis suggested a structure similar to the mitochondrial phylogeny, where most samples were classified into four genetic clusters corresponding to the four mtDNA subclades. However, a proportion of samples carrying SQUen mtDNA haplotypes formed an additional distinct cluster SHY. Those samples are found in the contact zone of the two species bearing mosaic and intermediate morphological characteristics. We detected an admixed ancestry in SHY from SBE and SQUen that conformed to an intrapopulation breeding scenario for at least hundreds of generations after the initial hybrid event, leading to a conclusion that SHY is a distinct and near‐panmictic population derived from natural interspecific hybridization. In addition, SQUes (Hainan Island endemic) is of special concern due to significant isolation and low genetic diversity. We suggest that seven evolutionarily significant units should be recognized to facilitate appropriate conservation actions. These findings also highlight the urgent need for further herpetological research and conservation in this region.
Species assemblage networks identify regional connectivity pathways among hydrothermal vents in the Northwest Pacific
Authors: Brunner Otis , Chen Chong , Giguère Thomas , Kawagucci Shinsuke , Tunnicliffe Verena , Watanabe Hiromi Kayama , Mitarai Satoshi 
Published: December 2022

AbstractThe distribution of species among spatially isolated habitat patches supports regional biodiversity and stability, so understanding the underlying processes and structure is a key target of conservation. Although multivariate statistics can infer the connectivity processes driving species distribution, such as dispersal and habitat suitability, they rarely explore the structure. Methods from graph theory, applied to distribution data, give insights into both connectivity pathways and processes by intuitively formatting the data as a network of habitat patches. We apply these methods to empirical data from the hydrothermal vent habitats of the Northwest Pacific. Hydrothermal vents are “oases” of biological productivity and endemicity on the seafloor that are imminently threatened by anthropogenic disturbances with unknown consequences to biodiversity. Here, we describe the structure of species assemblage networks at hydrothermal vents, how local and regional parameters affect their structure, and the implications for conservation. Two complementary networks were formed from an extensive species assemblage dataset: a similarity network of vent site nodes linked by weighted edges based on their pairwise assemblage similarity and a bipartite network of species nodes linked to vent site nodes at which they are present. Using these networks, we assessed the role of individual vent sites in maintaining network connectivity and identified biogeographic sub‐regions. The three sub‐regions and two outlying sites are separated by their spatial arrangement and local environmental filters. Both networks detected vent sites that play a disproportionately important role in regional pathways, while the bipartite network also identified key vent sites maintaining the distinct species assemblages of their sub‐regions. These regional connectivity pathways provide insights into historical colonization routes, while sub‐regional connectivity pathways are of value when selecting sites for conservation and/or estimating the multivent impacts from proposed deep‐sea mining.
Teaching the process of science with primary literature: Using the CREATE pedagogy in ecological courses
Authors: Smith Kevin G. , Paradise Christopher J. 
Published: December 2022

AbstractThere have been numerous calls for improved pedagogical practices in biological education, and there is a clear need for such improvements in ecology and related curricula. Most ecology‐related texts lack pedagogy and are designed to be content‐rich. National initiatives, such asVision & Change,provide guidance on undergraduate biology education, including increasing use of evidence‐based active learning, and taking a more conceptual and science practice skills approach. Biology education research is rich with evidence‐based teaching practices, which reveal that active learning approaches implemented in thoughtful ways lead to strong learning gains relative to lecture‐based course delivery. CREATE (Consider, Read, Elucidate the hypothesis, Analyze and interpret data, Think of the next Experiment) integrates evidence‐based active pedagogical practices into one approach to STEM education that focuses heavily on the process of science and science practice skills rather than content delivery by replacing the textbook with selected journal articles. The approach focuses on deep reading and analysis of primary literature; immersing students in the literature is an advantage of the pedagogy. CREATE was developed and tested in other biological disciplines (genetics and molecular biology) that have long been at the forefront of pedagogical best practices in biology. We transformed two upper‐level undergraduate ecological courses (Conservation Biology, and Biodiversity and Ecology) into CREATE courses. We provide examples of assignments, student work, and assessments of the approach, illustrating the various ways CREATE can be successfully implemented. The approach can be adopted in part, to ease into it and test it out, or in whole. We recommend that ecology teachers consider making their courses more active, if they have not already done so; adopting pedagogical practices embedded within CREATE can be a way to achieve active learning. The CREATE approach and other evidence‐based pedagogical best practices lead to strong learning gains and more inclusive learning environments.
Heart failure: an update from the last years and a look at the near future
Authors: Riccardi Mauro , Sammartino Antonio Maria , Piepoli Massimo , Adamo Marianna , Pagnesi Matteo , Rosano Giuseppe , Metra Marco , von Haehling Stephan , Tomasoni Daniela 
Published: December 2022

AbstractIn the last years, major progress occurred in heart failure (HF) management. Quadruple therapy is now mandatory for all the patients with HF with reduced ejection fraction. Whilst verciguat is becoming available across several countries, omecamtiv mecarbil is waiting to be released for clinical use. Concurrent use of potassium‐lowering agents may counteract hyperkalaemia and facilitate renin–angiotensin–aldosterone system inhibitor implementations. The results of the EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR‐Preserved) trial were confirmed by the Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (DELIVER) trial, and we now have, for the first time, evidence for treatment of also patients with HF with preserved ejection fraction. In a pre‐specified meta‐analysis of major randomized controlled trials, sodium–glucose co‐transporter‐2 inhibitors reduced all‐cause mortality, cardiovascular (CV) mortality, and HF hospitalization in the patients with HF regardless of left ventricular ejection fraction. Other steps forward have occurred in the treatment of decompensated HF. Acetazolamide in Acute Decompensated Heart Failure with Volume Overload (ADVOR) trial showed that the addition of intravenous acetazolamide to loop diuretics leads to greater decongestion vs. placebo. The addition of hydrochlorothiazide to loop diuretics was evaluated in the CLOROTIC trial. Torasemide did not change outcomes, compared with furosemide, in TRANSFORM‐HF. Ferric derisomaltose had an effect on the primary outcome of CV mortality or HF rehospitalizations in IRONMAN (rate ratio 0.82; 95% confidence interval 0.66–1.02; P = 0.070). Further options for the treatment of HF, including device therapies, cardiac contractility modulation, and percutaneous treatment of valvulopathies, are summarized in this article.
Spontaneous coronary hematoma concomitant with myocarditis: the first report of double cardiac complication of dengue
Authors: Corré Jérôme , Vally Shamir , Boiron Philippe , Bouillaud Yoann , Travers Jean‐Yves 
Published: December 2022

AbstractWe reported the case of a 33‐year‐old male who presented a dengue infection complicated by spontaneous coronary artery intramural hematoma associated with acute myocarditis. The initial presentation was a typical acute coronary syndrome with ST‐segment elevation. Coronary angiography and endocoronary optical coherence tomography confirmed the diagnosis of left anterior descending artery intramural hematoma. Cardiac magnetic resonance imaging revealed not only typical ischaemic injury but also lesions of acute myocarditis confirmed by native T1‐ and T2‐mapping, sub‐epicardial late gadolinium enhancement and pericardial effusion. This case highlights the multiple cardiac damages caused by dengue virus, their possible association (coincidental or linked?), and the impact of multimodal imaging on diagnosis and management.
An improved blockchain based encryption scheme for secure routing in wireless sensor network using machine learning technique
Authors: Meena Uma , Sharma Promila 
Published: December 2022

AbstractA secure routing scheme plays an integral role in ensuring the secure routing and efficiency of wireless sensor networks (WSNs). Recently, many studies have been undertaken to improve the data aggregation process, data security, and routing security. However, these approaches are highly suffered due to major limitations like time complexity, malicious attacks, and data insecurity. This research aims to develop an improved blockchain based encryption scheme for secure routing in wireless sensor networks using machine learning techniques. An improved artificial quantum beetle swarm neural network approach is proposed to perform the data aggregation among the sensor nodes. The cosine equivalent function and packet density correlation degree approach is emphasized to perform clustering in sensor nodes. The cluster head (CH) is selected based on the similarity of each sensor node. The Kalman filtering technique is introduced to filter out the data from unwanted malicious. This technique helps to filter the data before it is sent to the CH. Blockchain‐based encryption scheme is emphasized for data security by preventing malicious attacks during data transmission. The enhanced differential evaluation based firefly routing protocol is presented to maintain secure routing by choosing the optimal routing for the protected data transmission. Performance metrics such as latency, throughput, routing performance, energy consumption, FPR, blockchain (BC) computational performance, dead sensor count and average hop count are analyzed and compared with existing techniques. In an experimental scenario, the proposed approach achieves a maximum packet delay of 500 slots, throughput of 581 times/s, a latency of 0.31 ms, a computation complexity of 0.6, and a routing complexity of 2081 ms with a BC computation time of 95 ms. The performance of the proposed approach shows a better result than other existing approaches.
Bendamustine and rituximab is well‐tolerated and efficient in the treatment of indolent non‐Hodgkin's lymphoma and mantle cell lymphoma in elderly: A single center observational study
Authors: Kotchetkov Rouslan , Drennan Ian R. , Susman David , DiMaria Erica , Gerard Lauren , Nay Derek , Prica Anca 
Published: December 2022

AbstractBendamustine and rituximab (BR) is a preferred first‐line therapy for indolent non‐Hodgkin's lymphoma (iNHL) and mantle cell lymphoma (MCL); however, few reports on BR performance in elderly patients are available to date. We compared safety and efficacy of BR in patients ≥70 years (elderly) vs <70 years (younger) treated at our institution. Among 201 patients, 113 were elderly (median age: 77 years), including 38 patients ≥80 years, and 88 were younger (median age: 62 years). Elderly patients had more bone marrow involvement by lymphoma, anemia, ECOG status 3 and high‐risk disease follicular lymphoma (P < .05 for all). Fifty‐four percent of elderly received full dose of bendamustine vs 79.5% of younger patients. More elderly patients (54%) vs younger (43.2%) experienced treatment delay. Less elderly proceeded to rituximab maintenance. Overall, the number of adverse events per patient and transformed B‐Cell lymphoma/secondary malignancies were similar between groups. Elderly patients had less febrile neutropenia, rituximab‐associated infusion reactions, but more herpes zoster reactivation. There were more deaths in the elderly (37.2%) vs younger (10.2%) groups (P < .001), mainly due to non‐lymphoma‐related causes. With median follow‐up of 42 months [4.0‐97.0] disease‐free survival for the elderly was similar to younger patients. There was no difference between patients <80 and ≥80 years (P = .274). In conclusion, the real‐world elderly patients have more advanced disease and higher ECOG status. BR is well‐tolerated; elderly patients had lower incidence of febrile neutropenia. Dose reduction and treatment delays are common, but BR efficacy was not affected even in very old patients (≥80 years).
Front Cover
Authors: Guezzi Nizar , Lee Changho , Le Thanh Dat , Seong Hyojin , Choi Kang‐Ho , Min Jung‐Joon , Yu Jaesok 
Published: December 2022

This study presents a simple, but robust and efficient denoising technique for fast optical resolution photoacoustic microscopy system (OR‐PAM). Impulsive noise and background noise in photoacoustic images are common issues of OR‐PAM system when laser power is limited. Our developed multi‐stage adaptive noise reduction technique efficiently and robustly removes the noises under noisy data acquisition conditions, providing a strong foundation for photoacoustic microscopy with limited laser power.Further details can be found in the article by Nizar Guezzi, Changho Lee, Thanh Dat Le, Hyojin Seong, Kang‐Ho Choi, Jung‐Joon Min, and Jaesok Yu (e202200164).
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Induced expression of miR‐1250‐5p exerts tumor suppressive role in triple‐negative breast cancer cells
Authors: Shuaib Mohd , Kumar Shashank 
Published: December 2022

AbstractTriple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and it has a prevalence rate of 15%–20% among all breast cancer cases in younger women. Still, the underlying molecular mechanisms of its pathogenesis are not entirely understood. In the previous study, we identified that microRNA (miR)‐1250‐5p is significantly down‐expressed in TNBC cells. Thus, in the present study, we explore the functional anticancer role of miR‑1250‑5p in the transient mimic transfected TNBC cells. 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay was used to examine the effect of miR‐1250‐5p on cell viability of TNBC (MDA‐MB‐231 and MDA‐MB‐453) cells. The confocal microscopy, quantitative real‐time polymerase chain reaction, and western blot analysis techniques were used to assess the effect of miR‐1250‐5p on cancer hallmarks in test cells. Induced miR‑1250‐5p expression in MDA‐MB‐231 and MDA‐MB‐453 cells decreased cell viability in a time‐dependent manner. Increased miR‑1250‐5p expression levels significantly decreased cell cycle G1/S phase transition markers (Cyclin D1 and CDK4) at messenger RNA (mRNA) and protein levels in TNBC cells compared to scrambled sequence transfected cells. Transient transfection of TNBC cells with miR‐1250‐5p mimic increased apoptosis in TNBC cells by increasing the level of active caspase (Caspase 8 and Caspase 3) of the intrinsic pathway. Apoptosis‐related morphological changes were also observed in the test cells. Further, the induced expression of miR‐1250‐5p significantly decreased epithelial‐mesenchymal transition (EMT) by altering the mRNA and protein levels of E‐cadherin and Vimentin. Moreover, results of confocal microscopy revealed increased reactive oxygen species generation, and decreased mitochondria membrane potential in miR‐1250‐5p mimic transient transfected TNBC cells. In conclusion, miR‑1250‐5p acts as tumor suppressor in TNBC cells and its induction by therapeutics might be a novel strategy for the disease treatment.
Comparison of Maintenance Dose Predictions by Warfarin Dosing Algorithms Based on Chinese and Western Patients
Authors: Deng Jiexin , Wang Yi , An Xiaokang 
Published: December 2022

AbstractWarfarin has a long record of safe and effective clinical use, and it remains one of the most commonly prescribed drugs for the prevention and treatment of thromboembolic conditions even in the era of direct oral anticoagulants. To address its large interindividual variability and narrow therapeutic window, the Clinical Pharmacogenetics Implementation Consortium has recommended using pharmacogenetic dosing algorithms, such as the ones developed by the International Warfarin Pharmacogenetics Consortium (IWPC) and by Gage et al, to dose warfarin when genotype information is available. In China, dosing algorithms based on local patient populations have been developed and evaluated for predictive accuracy of warfarin maintenance doses. In this study, percentage deviations of doses predicted by 15 Chinese dosing algorithms from that by IWPC and Gage algorithms were systematically evaluated to understand the differences between Chinese and Western algorithms. In general, dose predictions by Chinese dosing algorithms tended to be lower than those predicted by IWPC or Gage algorithms for the most prevalent VKORC1 and CYP2C9 genotypes in the Chinese population. The extent of negative prediction deviation appeared to be largest in the younger age group with smaller body weight. Our findings are consistent with previous reports that Asians have a higher sensitivity to warfarin and require lower doses than Western populations.