bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging Recommendations for Diagnosis, Staging, and Management of Prostate Cancer
Authors: Sable Nilesh P. , Bakshi Ganesh K. , Raghavan N. , Bakshi Hemang , Sharma Rakesh , Menon Santosh , Kumar Prabhash , Katdare Aparna , Popat Palak 
Published: March 2023

AbstractThe Prostate Carcinoma Guidelines Panel have formulated these guidelines to assist medical professionals in the evidence-based management of prostate cancer. These have been formulated by a panel consisting of Indian multidisciplinary group of radiologists, uro-oncologists, urologists, radiation oncologists, medical oncologists, and pathologists. These recommendations present the best evidence available to the clinicians; however, using these recommendations will not always result in the best outcome. They aid in decision making for individual patients; however, these will never replace clinical expertise when making treatment decisions. Taking personal values and preferences or individual circumstances of patients into account is necessary for final treatment decision. Guidelines are not mandatory and should not to be referred as a legal standard of care.
Imaging Guidelines and Recommendations for Diagnosis, Surveillance, and Management of Pediatric CNS and Spinal Tumors
Authors: Kapadia Tejas , Sahu Arpita , Mahajan Abhishek , Ahuja Ankita , Chatterjee Abhishek , Sahu Amit , Warade Anshu , Padashetty Shubham , Vijan Antariksh , Chidambaranthan Natesan , Dasgupta Archya , Sridhar Epari , Sahay Ayushi , Shetty Prakash , Prasad Maya , Chinnaswamy Girish , Moiyadi Aliasgar , Gupta Tejpal , Gala Foram , Sankhe Shilpa 
Published: March 2023

AbstractCentral nervous system (CNS) tumors are the second most common cause of cancer in children when incidence rates of cancer are estimated according to the Indian population dynamics based on 2011 consensus. As per the estimates, CNS tumors account for 20.1% of cancer burden in children aged between 0 and 14 years and 16.8% when 0 to 19 years age group is considered. The most common pediatric brain tumors are astrocytoma and medulloblastoma followed by other embryonal tumors, craniopharyngioma, and ependymal tumors. The incidence of CNS tumors in children from India is similar to the western high-income countries, other than slightly higher incidence of craniopharyngioma in Indian children.
Nanoscale structure of a hybrid aqueous–nonaqueous electrolyte
Authors: Saboungi Marie-Louise , Borodin Oleg , Price David L. , Farago Bela , González Miguel A. , Kohara Shinji , Mangin-Thro Lucile , Wildes Andrew , Yamamuro Osamu 
Published: March 2023

A new class of electrolytes have been reported, hybridizing aqueous with non-aqueous solvents, which combines non-flammability and non-toxicity characteristics of aqueous electrolytes with the superior electrochemical stability of non-aqueous systems. Here, we report measurements of the structure of an electrolyte composed of an equal-mass mixture of 21 m LiTFSI-water and 9 m LiTFSI-dimethyl carbonate using high-energy x-ray diffraction and polarized neutron diffraction with isotope substitution. Neutron structure factors from partially and fully deuterated samples exhibit peaks at low scattering vector Q that we ascribe to long-range correlations involving both solvent molecules and TFSI− anions. We compare both sets of measurements with results of molecular dynamics simulations based on a polarizable force field. The structures derived from simulations are generally in agreement with those measured, except that neutron structure factors predicted for two partially deuterated samples show very intense scattering increasing up to the low-Q limit of simulation, indicating a partial segregation between the two solvents not observed in experimental measurements.
Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation
Authors: Feehan Joanna M. , Wang Junli , Sun Xinhua , Choi Jihyeon , Ahn Hee-Kyung , Ngou Bruno Pok Man , Parker Jane E. , Jones Jonathan D. G. 
Published: March 2023

Plant disease resistance involves both detection of microbial molecular patterns by cell-surface pattern recognition receptors and detection of pathogen effectors by intracellular NLR immune receptors. NLRs are classified as sensor NLRs, involved in effector detection, or helper NLRs required for sensor NLR signaling. TIR-domain-containing sensor NLRs (TNLs) require helper NLRs NRG1 and ADR1 for resistance, and helper NLR activation of defense requires the lipase-domain proteins EDS1, SAG101, and PAD4. Previously, we found that NRG1 associates with EDS1 and SAG101 in a TNL activation-dependent manner [X. Sun
et al.
,
Nat. Commun.
12
, 3335 (2021)]. We report here how the helper NLR NRG1 associates with itself and with EDS1 and SAG101 during TNL-initiated immunity. Full immunity requires coactivation and mutual potentiation of cell-surface and intracellular immune receptor-initiated signaling [B. P. M. Ngou, H.-K. Ahn, P. Ding, J. D. G. Jones,
Nature
592
, 110–115 (2021), M. Yuan
et al.
,
Nature
592
, 105–109 (2021)]. We find that while activation of TNLs is sufficient to promote NRG1–EDS1–SAG101 interaction, the formation of an oligomeric NRG1–EDS1–SAG101 resistosome requires the additional coactivation of cell-surface receptor-initiated defense. These data suggest that NRG1–EDS1–SAG101 resistosome formation in vivo is part of the mechanism that links intracellular and cell-surface receptor signaling pathways.
Selective binding and periodic arrangement of magic boron clusters on monolayer borophene
Authors: Lv Haifeng , Chen Caiyun , Li Wenbin , Zhuo Zhiwen , Cheng Peng , Zhang Yi-Qi , Feng Baojie , Wu Kehui , Wu Xiaojun , Chen Lan 
Published: March 2023

The synthesis and characterization of small boron clusters with unique size and regular arrangement are crucial for boron chemistry and two-dimensional borophene materials. In this study, together with theoretical calculations, the joint molecular beam epitaxy and scanning tunneling microscopy experiments achieve the formation of unique B
5
clusters on monolayer borophene (MLB) on a Cu(111) surface. The B
5
clusters tend to selectively bind to specific sites of MLB with covalent boron–boron bonds in the periodic arrangement, which can be ascribed to the charge distribution and electron delocalization character of MLB and also prohibits nearby co-adsorption of B
5
clusters. Furthermore, the close-packed adsorption of B
5
clusters would facilitate the synthesis of bilayer borophene, exhibiting domino effect-like growth mode. The successful growth and characterization of uniform boron clusters on a surface enrich the boron-based nanomaterials and reveal the essential role of small clusters during the growth of borophene.
OBSCN
restoration via
OBSCN-AS1
long-noncoding RNA CRISPR-targeting suppresses metastasis in triple-negative breast cancer
Authors: Guardia Talia , Zhang Yuqi , Thompson Keyata N. , Lee Se Jong , Martin Stuart S. , Konstantopoulos Konstantinos , Kontrogianni-Konstantopoulos Aikaterini 
Published: March 2023

Mounting evidence implicates the giant, cytoskeletal protein obscurin (720 to 870 kDa), encoded by the
OBSCN
gene, in the predisposition and development of breast cancer. Accordingly, prior work has shown that the sole loss of
OBSCN
from normal breast epithelial cells increases survival and chemoresistance, induces cytoskeletal alterations, enhances cell migration and invasion, and promotes metastasis in the presence of oncogenic KRAS. Consistent with these observations, analysis of Kaplan–Meier Plotter datasets reveals that low
OBSCN
levels correlate with significantly reduced overall and relapse-free survival in breast cancer patients. Despite the compelling evidence implicating
OBSCN
loss in breast tumorigenesis and progression, its regulation remains elusive, limiting any efforts to restore its expression, a major challenge given its molecular complexity and gigantic size (~170 kb). Herein, we show that
OBSCN-Antisense RNA 1
(
OBSCN-AS1
), a novel nuclear long-noncoding RNA (lncRNA) gene originating from the minus strand of
OBSCN
, and
OBSCN
display positively correlated expression and are downregulated in breast cancer biopsies.
OBSCN-AS1
regulates
OBSCN
expression through chromatin remodeling involving H3 lysine 4 trimethylation enrichment, associated with open chromatin conformation, and RNA polymerase II recruitment. CRISPR-activation of
OBSCN-AS1
in triple-negative breast cancer cells effectively and specifically restores
OBSCN
expression and markedly suppresses cell migration, invasion, and dissemination from three-dimensional spheroids in vitro and metastasis in vivo. Collectively, these results reveal the previously unknown regulation of
OBSCN
by an antisense lncRNA and the metastasis suppressor function of the
OBSCN-AS1/OBSCN
gene pair, which may be used as prognostic biomarkers and/or therapeutic targets for metastatic breast cancer.
Stability in inverse problem of an elastic plate with a curved middle surface
Authors: Fu Song-Ren , Yao Peng-Fei 
Published: March 2023

Abstract
We consider stability in an inverse problem of determining three spatially varying functions including the source term and the mass density for a curved plate by the Riemannian geometrical approach. The stability is derived by the Carleman estimates and observability inequalities. Two kinds of boundary conditions are considered: one is the hinged boundary conditions and the other is the clamped boundary conditions. In particular, the case of the Euler–Bernoulli plate is included.
Effects of oxygen concentration on streamer propagation and ozone production in a single-filament streamer discharge at atmospheric pressure
Authors: Komuro Atsushi , Yoshino Akihiro , Wei Zhenyu , Ono Ryo 
Published: March 2023

Abstract
Limited research has been conducted on the formation mechanism of chemically active species in streamer discharges with respect to the oxygen concentration, which is critical to various applications such as ozone generation, air purification, and plasma-assisted combustion, among others. Herein, the oxygen concentration in an N2/O2 gas atmosphere is varied from 1% to 99% under atmospheric pressure and room temperature to investigate changes in the characteristics of streamer discharge propagation and generation of chemically active species. As the oxygen concentration increases from 10% to 90%, the decay rate of the discharge current, propagation velocity of the primary streamer, and ozone production efficiency increase. These phenomena are qualitatively explained by the electron attachment reaction to oxygen molecules and changes in the electron energy distribution function caused by the change in the oxygen concentration. However, the amount of discharge emission from N2(C) cannot be explained by changes in the fraction of electron energy lost in excitation of N2(C) and its quantum yield, implying that changes in the production of N2(C) in the primary and secondary streamers must be considered in a spatiotemporal manner. This study demonstrates that the ozone and N2(C) production characteristics in streamer discharges vary nonlinearly with respect to the oxygen concentration.
Observation of photoinduced polarons in semimetal 1T-TiSe2
Authors: Huang Yin , Lv Senhao , Liu Heyuan , Cheng Qiuzhen , Biao Yi , Lu Hongliang , Lin Xiao , Wang Zhuan , Yang Haitao , Chen Hailong , Weng Yu-Xiang 
Published: March 2023

Abstract
In this work, ultrafast carrier dynamics of mechanically exfoliated 1T-TiSe2 flakes from the high-quality single crystals with self-intercalated Ti atoms are investigated by femtosecond transient absorption spectroscopy. The observed coherent acoustic and optical phonon oscillations after ultrafast photoexcitation reveal the strong electron–phonon coupling in 1T-TiSe2. The ultrafast carrier dynamics probed in both visible and mid-infrared regions indicate that some photogenerated carriers localize near the intercalated Ti atoms and form small polarons rapidly within several picoseconds after photoexcitation due to the strong and short-range electron–phonon coupling. The formation of polarons leads to a reduction of carrier mobility and a long-time relaxation process of photoexcited carriers for several nanoseconds. The formation and dissociation rates of the photoinduced polarons are dependent on both the pump fluence and the thickness of TiSe2 sample. This work offers new insights into the photogenerated carrier dynamics of 1T-TiSe2, and emphasizes the effects of intercalated atoms on the electron and lattice dynamics after photoexcitation.
Reduced graphene oxide/ionic liquid composites with tunable interlayer spacing for improved charge/discharge kinetics in supercapacitors
Authors: Korkut Ayse Saliha , Uralcan Betul 
Published: March 2023

Abstract
The large specific surface area and high conductivity of reduced graphene oxide (RGO) make it a promising material for supercapacitors. However, aggregation of graphene sheets into graphitic domains upon drying hampers supercapacitor performance by drastically impeding ion transport inside electrodes. Here, we present a facile approach to optimize charge storage performance in RGO-based supercapacitors by systematically tuning their micropore structure. To this end, we combine RGOs with room temperature ionic liquids during electrode processing to impede stacking of sheets into graphitic structures with small interlayer distance. In this process, RGO sheets function as the active electrode material while ionic liquid serves both as a charge carrier and a spacer to control interlayer spacing inside electrodes and form ion transport channels. We show that composite RGO/ionic liquid electrodes with larger interlayer spacing and more ordered structure exhibit improved capacitance and charging kinetics.
Enhanced thermal properties of epoxy composites by constructing thermal conduction networks with low content of three-dimensional graphene
Authors: Li Changzheng , Huang Minjin , Zhang Zhe , Qin Yaoyu , Liang Lizhe , Tian Zhi Qun , Ali Asad , Shen Pei Kang 
Published: March 2023

Abstract
Micro/nano electronic devices heat dissipation depends heavily on the thermal interface materials (TIMs). Despite notable progress, it is hard to efficaciously enhance the thermal properties of the hybrid TIMs with high-load additives due to an absence of effective heat transfer routes. Herein, the low content of three-dimensional (3D) graphene with interconnected networks is adopted as the additive to improve the thermal properties of epoxy composite TIMs. The thermal diffusivity and thermal conductivity of the as-prepared hybrids were dramatically improved by constructing thermal conduction networks after adding 3D graphene as fillers. The 3D graphene/epoxy hybrid’s optimal thermal characteristics were observed at 1.5 wt% of 3D graphene content, corresponding to a maximum enhancement of 683%. Besides, heat transfer experiments were further performed to determine the superb heat dissipation potential of the 3D graphene/epoxy hybrids. Moreover, the 3D graphene/epoxy composite TIM was also applied to high-power LED to improve heat dissipation. It effectively reduced the maximum temperature from 79.8 °C to 74.3 °C. These results are beneficial for the better cooling performance of electronic devices and provide useful guidelines for advancing the next-generation TIMs.
Preparation of an amphiphilic peptide (P13) with proton sponge effect and analysis of its antitumor activity
Authors: Wu Yujia , Jin Weihao , Wang Shanyi , Li Wanzhen , Tao Yugui , Wang Jun , Yang Kai , Zhang Weiwei , Gui Lin , Ge Fei 
Published: March 2023

Abstract
In order to prevent drugs from being captured and degraded by the acidic environment of organelles, such as lysosomes, after entering cells, this study designed and synthesized a novel carrier amphiphilic polypeptide (DGRHHHLLLAAAA), designated P13, for use as a tumor-targeting drug delivery vehicle. The P13 peptide was synthesized by the solid phase synthesis method, and its self-assembly behavior and drug-loading capacity in aqueous solution were studied and characterized in vitro. Doxorubicin (DOX) was loaded by dialysis method, and P13 and DOX were mixed at a mass ratio of 6:1 to form regular rounded globules. The acid–base buffering capacity of P13 was investigated determined by acid–base titration. The results revealed that P13 had excellent acid–base buffering capacity, a critical micelle concentration value of about 0.000 21 g l−1, and the particle size of P13-Dox nanospheres was 167 nm. The drug encapsulation efficiency and drug loading capacity of micelles were 20.40 ± 1.21% and 21.25 ± 2.79%, respectively. At the concentration of 50 μg ml−1 of P13-DOX , the inhibition rate was 73.35%. The results of the in vivo antitumor activity assay in mice showed that P13-DOX also exhibited excellent inhibitory effect on tumor growth, compared with the tumor weight of 1.1 g in the control group, the tumor weight in the P13-DOX-treated group was only 0.26 g. Additionally, the results of hematoxylin and eosin staining of the organs showed that P13-DOX had no damaging effect on normal tissues. The novel amphiphilic peptide P13 with proton sponge effect designed and prepared in this study is expected to be a promising tumor-targeting drug carrier with excellent application potential.
Modeling plasma-induced surface charge effects on CO2 activation by single atom catalysts supported on reducible and irreducible metal oxides
Authors: Doherty Francis , Goldsmith Bryan R 
Published: March 2023

Abstract
The accumulation of negative surface charge on catalytic surfaces in the presence of low-temperature plasma (LTP) could influence catalytic performance. However, it is difficult to disentangle the role of surface charging and other LTP catalytic effects in experiment. Herein, we use density functional theory (DFT) modeling to understand the effect of plasma-induced surface charging on CO2 activation by atomically dispersed single atom (SA) catalysts on both reducible and irreducible metal oxide supports. We model CO2 adsorption strength and CO2 dissociation barriers for Co1, Ni1, Cu1, Rh1, Pd1, and Ag1 SAs on both reducible and irreducible supports, namely, CeO2(100), TiO2(101), and γ-Al2O3(110), to elucidate trends. We find that accumulated surface charge on the SA increases the CO2 adsorption strength and decreases the CO2 dissociation barrier for all studied SA/support combinations. For both charged and uncharged (neutral) systems, SAs on the reducible CeO2(100) support generally adsorb CO2 more weakly compared to when on irreducible supports like γ-Al2O3(110). SAs on γ-Al2O3(110) typically have larger barriers for CO2 dissociation for both charged and uncharged systems compared to TiO2(101) and CeO2(100). The magnitude of surface charging effects on CO2 binding energies and dissociation barriers depends sensitively on both the SA and the support. In some cases, the CO2 activation trends qualitatively change between neutral and charged systems for a fixed SA across different supports. This DFT modeling study demonstrates that surface charging should be considered in strong electric fields because it can have a large effect on molecule adsorption and bond-breaking on catalytic surfaces.
Effect of nano-size on magnetostriction of BiFeO3 and exceptional magnetoelectric coupling properties of BiFeO3_P(VDF-TrFE) polymer composite films for magnetic field sensor application
Authors: Pradhan Sonali , Deshmukh Pratik , Kambale Rahul C , Darvade Tulshidas C , Satapathy S , Majumder Shovan K 
Published: March 2023

Abstract
The existence of magnetostriction in bulk BiFeO3 is still a matter of investigation and it is also an issue to investigate the magnetostriction effect in nano BiFeO3. Present work demonstrates the existence of magnetostrictive strain in superparamagnetic (SPM) BiFeO3 nanoparticles at room temperature and the magnetoelectric (ME) coupling properties in composite form with P(VDF-TrFE). Despite few reports on the magnetostriction effect in bulk BiFeO3 evidenced by the indirect method, the direct method (strain gauge) was employed in this work to examine the magnetostriction of SPM BiFeO3. In addition, a high ME coupling coefficient was observed by the lock-in technique for optimized BiFeO3_P(VDF-TrFE) nanocomposite film. These nanocomposite films also exhibit room-temperature multiferroic properties. These results provide aspects of material with immense potential for practical applications in spintronics and magneto-electronics applications. We report a ME sensor using SPM BiFeO3_P(VDF-TrFE) nanocomposite film for detection of ac magnetic field.
First-principles calculations of electron-phonon coupling in NaSnSb: buckling and pressurization
Authors: Mace (徐文轩) George 
Published: March 2023

Abstract
In this paper, the electron-phonon coupling (EPC) properties of topological material NaSnSb has been explored, whose low phonon branch dominates the EPC constant λ. NaSnSb can remain the strength of its EPC with a slight compression of the distance of the Na and Sb atoms along the z-axis (z
Na–Sb), while further compression or stretching would destroy the strength of its EPC. By pressing, in the pressure range of 2 GPa, the superconducting transition temperature (T
c) of NaSnSb behaves similar to that of FeSe in the same pressure range, with a local minimum at 1 GPa and a maximum at 1.5 GPa. Both compressing z
Na–Sb and pressure lead to phonon softening of NaSnSb. The phonon softening induced by compressing z
Na–Sb is three-dimensional, whereas the phonon softening induced by compression is two-dimensional.
Record field in a 10 mm-period bulk high-temperature superconducting undulator
Authors: Zhang Kai , Pirotta Andrew , Liang Xiaoyang , Hellmann Sebastian , Bartkowiak Marek , Schmidt Thomas , Dennis Anthony , Ainslie Mark , Durrell John , Calvi Marco 
Published: March 2023

Abstract
A 10 mm-period, high-temperature superconducting (HTS) undulator consisting of 20 staggered-array GdBa2Cu3O7−x
(GdBCO) bulk superconductors has been fabricated and tested successfully. Each GdBCO disk was machined into a half-moon shape with micro-meter accuracy and shrink-fitted into a slotted oxygen-free copper disk which provided pre-stress and effective conduction-cooling. The HTS undulator prototype, consisting of GdBCO disks, copper disks, and CoFe poles fitted in a long copper shell, was field-cooled magnetized in fields of up to 10 T at 10 K. An undulator field of 2.1 T in a 4 mm magnetic gap was obtained. This field is the largest reported yet for the same gap and period length and exceeds the target value of 2 T for the meter-long HTS undulator scheduled for the hard x-ray I-TOMCAT beamline in the Swiss Light Source 2.0. We have demonstrated that bulk superconductor based undulators can provide significantly improved performance over alternative technologies.