bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety analysis of pemigatinib leveraging the US Food and Drug administration adverse event reporting system
Authors: Zhang Ying , Ran Li , Liang Yongchao , Zhang Yanqiu , An Zhuoling 
Published: July 2023

Background: Cholangiocarcinoma (CCA) is a highly lethal and aggressive epithelial tumor of the hepatobiliary system. A poor prognosis, propensity for relapse, low chance of cure and survival are some of its hallmarks. Pemigatinib, the first targeted treatment for CCA in the United States, has been demonstrated to have a significant response rate and encouraging survival data in early-phase trials. The adverse events (AEs) of pemigatinib must also be determined.Objective: To understand more deeply the safety of pemigatinib in the real world through data-mining of the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).Methods: Disproportionality analysis was employed in a retrospective pharmacovigilance investigation to identify the AEs linked to pemigatinib use as signals. Data were collected between 1 January 2020 to 30 June 2022. Four data-mining methods (proportional reporting odds ratio; proportional reporting ratio; Bayesian confidence propagation neural networks of information components; empirical Bayes geometric means) were used to calculate disproportionality.Results: A total of 203 cases using pemigatinib as the prime-suspect medication were found in our search, which involved 99 preferred terms (PTs). Thirteen signals of pemigatinib-induced AEs in seven System Organ Classes were detected after confirming the four algorithms simultaneously. Nephrolithiasis was an unexpected significant AE not listed on the drug label found in our data-mining. Comparison of the differences between pemigatinib and platinum drugs in terms of 33 PTs revealed that 13 PTs also met the criteria of the four algorithms. Ten of these PTs were identical to those compared with all other drugs, in which (excluding a reduction in phosphorus in blood) other PT signal values were higher than those of all other drugs tested. However, comparison of the differences between pemigatinib and infigratinib in terms of the 33 PTs revealed no significant signals in each algorithm method.Conclusion: Some significant signals were detected between pemigatinib use and AEs. PTs with apparently strong signals and PTs not mentioned in the label should be taken seriously.
Dissociated coupling between cerebral oxygen metabolism and perfusion in the prefrontal cortex during exercise: a NIRS study
Authors: Hiura Mikio , Funaki Akio , Shibutani Hirohide , Takahashi Katsumi , Katayama Yoichi 
Published: July 2023

Purpose: The present study used near-infrared spectroscopy to investigate the relationships between cerebral oxygen metabolism and perfusion in the prefrontal cortex (PFC) during exercises of different intensities.Methods: A total of 12 recreationally active men (age 24 ± 6 years) were enrolled. They performed 17 min of low-intensity exercise (ExL), followed by 3 min of moderate-intensity exercise (ExM) at constant loads. Exercise intensities for ExL and ExM corresponded to 30% and 45% of the participants’ heart rate reserve, respectively. Cardiovascular and respiratory parameters were measured. We used near-infrared time-resolved spectroscopy (TRS) to measure the cerebral hemoglobin oxygen saturation (ScO2) and total hemoglobin concentration ([HbT]), which can indicate the cerebral blood volume (CBV). As the cerebral metabolic rate for oxygen (CMRO2) is calculated using cerebral blood flow (CBF) and ScO2, we assumed a constant power law relationship between CBF and CBV based on investigations by positron emission tomography (PET). We estimated the relative changes in CMRO2 (rCMRO2) and CBV (rCBV) from the baseline. During ExL and ExM, the rate of perceived exertion was monitored, and alterations in the subjects’ mood induced by exercise were evaluated using the Profile of Moods Scale-Brief.Results: Three minutes after exercise initiation, ScO2 decreased and rCMRO2 surpassed rCBV in the left PFC. When ExL changed to ExM, cardiovascular variables and the sense of effort increased concomitantly with an increase in [HbT] but not in ScO2, and the relationship between rCMRO2 and rCBV was dissociated in both sides of the PFC. Immediately after ExM, [HbT], and ScO2 increased, and the disassociation between rCMRO2 and rCBV was prominent in both sides of the PFC. While blood pressure decreased and a negative mood state was less prominent following ExM compared with that at rest, ScO2 decreased 15 min after exercise and rCMRO2 surpassed rCBV in the left PFC.Conclusion: Dissociated coupling between cerebral oxidative metabolism and perfusion in the PFC was consistent with the effort required for increased exercise intensity and associated with post-exercise hypotension and altered mood status after exercise. Our result demonstrates the first preliminary results dealing with the coupling between cerebral oxidative metabolism and perfusion in the PFC using TRS.
Mindful sharenting: how millennial parents balance between sharing and protecting
Authors: Walrave Michel , Robbé Sofie , Staes Luna , Hallam Lara 
Published: July 2023

BackgroundSharenting, parents’ sharing of personal information about children on social media is becoming increasingly controversial. Its potential risks have drawn some parents to engage in mindful sharenting: parents’ application of strategies to reduce the potentially negative effects of sharenting, as they are aware of the impact sharenting can have on the child’s privacy.ObjectiveThis study aims to investigate parents’ motives for engaging in mindful sharenting, the strategies they implement and how relatives and acquaintances react.MethodsIn-depth interviews were conducted with eight mother–father dyads in Belgium. At least one of both respondents had to be born between 1980 and 2000 (i.e., millennial parents), having a child aged between 0 and 6 years. Conversations were transcribed ad verbatim, coded in Nvivo, and were analyzed thematically.ResultsThe reasons leading parents to engage in mindful sharenting were previous negative experiences they encountered or heard of from acquaintances. In addition, parents aimed to safeguard their child’s privacy and prevent any misuse of their identity or any other forms of aggression. Furthermore, certain parents wish to grant their children the freedom to choose which media content about them is shared online at a later stage in life. As parents are aware of potential benefits of sharenting, they employ strategies to ensure their child’s privacy, while still enjoying the benefits sharenting offers them. These strategies include photographing the child from a distance, the child looking away from the camera, focusing only on a body part, covering the face with an emoticon, blurring the face, or cutting recognizable parts from the photo. However, parents engaging in mindful sharenting are also confronted with questions and negative comments from family members and acquaintances. This makes them feel like they must justify their decision. Moreover, they are sometimes confronted with family members posting identifiable pictures of their child, which leads to privacy turbulence, and parents having to clarify and renegotiate the privacy boundaries concerning image sharing.ConclusionParents deciding to engage in mindful sharenting engage in several strategies to balance between the opportunities sharenting can offer them, the social pressure they experience to post child-related updates, and their objective to protect their child’s privacy. However, some parents face criticism, making them feel pressured to justify their decision and having to clearly explain to family members not to make identifiable pictures of their child available online.
Communicative and linguistic factors influencing language development at 30 months of age in preterm and full-term children: a longitudinal study using the CDI
Authors: Ogneva Anastasiia , Pérez-Pereira Miguel 
Published: July 2023

IntroductionPrevious studies showed that very preterm children have a delay in communicative (gestures) and linguistic development as compared to full-term children. Earlier use of gestures, as well as of word comprehension and production, have been found to be predictive of subsequent word production and/or language delay in both very preterm and full-term children. Not many studies on communicative antecedents of language, however, have been carried out with low-risk preterm children in comparison to full-term children.MethodsIn the present study a sample (N = 142) of low-risk preterm children has been followed using the Galician version of the Communicative Development Inventories (CDI) at the ages of 10, 22, and 30 months of age and their results were compared to the results from a sample (N = 49) of full-term children at the same ages. The determinants of language measures (vocabulary and grammar) at 30 months of age have been studied through linear regression analyses.ResultsANOVA results indicate that there were no significant differences between the groups in any of the measures obtained with the CDI at any time, nor were there any differences in lexical or grammatical developmental trajectories between both groups (repeated measures ANOVA). Linear regression analyses showed that the predictors of language at 30 months of age are somewhat different for the full-term than for the preterm group.DiscussionWhile the use of first communicative gestures at 10 months is a predictor of word production at 30 months of age for the full-term group, participation in games and routines seems to play a significant predictive role for preterm children. Word production at 22 months is the factor with a major incidence on word production at the age of 30 months for both groups. Previous specific measures of grammatical development have a clear determinant role in grammar measures at 30 months of age for the full-term children, while in the case of preterm children previous lexical development seems to be more relevant.
Educating to sexuality care: the nurse educator’s experience in a multicenter study
Authors: Gradellini Cinzia , Mecugni Daniela , Castagnaro Elena , Frade Fátima , da Luz Ferreira Barros Maria , Palma Sara , Bocos-Reglero María Jesús , Gomez-Cantarino Sagrario 
Published: July 2023

BackgroundSexuality is an issue inherent in the lives of all human beings. Education for Sexuality takes place informally, through relationships with the environment, with the family as a model, and formally, as a pedagogical practice in Teaching. Education for sexuality is recognized as an instrument of social transformation that leads to changes in behaviors and norms related to sexuality.ObjectivesKnowing the perception of nursing professors about sexuality education in professional training, recognizing attitudes of these professors in relation to sexual education and identifying barriers in education for sexuality.MethodsExploratory and descriptive study, using qualitative methodology. Data collection was carried out from semi-structured interviews and thematic analysis.ResultsThe interviewees consider sexuality education to be very important, being taught in the nursing course, addressing different themes. In general, they reported feeling comfortable teaching these topics. The identified barriers to the level of education students are in, students’ knowledge and reactions to the topic, religious and cultural issues, and the time available to talk about the topic and professional aspects.ConclusionSexuality is a fundamental theme in nursing education and needs to be further explored to overcome the barriers associated with its approach.
Oligosaccharides and diet-related dilated cardiomyopathy in beagles
Authors: Bokshowan Elise , Olver T. Dylan , Costa Matheus de O. , Weber Lynn P. 
Published: July 2023

IntroductionIn 2018 the US Food and Drug Administration reported a potential link between grain-free, legume-containing dog foods and the development of canine dilated cardiomyopathy in atypical breeds. One hypothesis was that high oligosaccharide content in legumes reduced bioavailability of taurine, an amino acid with some previous links to canine dilated cardiomyopathy.MethodsTo address this hypothesis, in the present study, 8 Beagle dogs consumed four diets: a husbandry commercial dental diet, and three test diets formulated with either 30% rice (control), 30% pea (grain-free) or 30% rice with the addition of 1% raffinose (the predominant oligosaccharide found in peas). The study was conducted in a randomized, crossover design with 5 week feeding periods. Measurement of basic health parameters (weight, body condition score, complete blood cell count, chemistry panel), plasma amino acids, cardiac biomarkers (plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac-specific troponin I), fecal bile acids and echocardiographic exams were completed pre-study after feeding the husbandry diet as well as after each test feeding period.ResultsEchocardiography showed 9–11% reduction in ejection fraction and 17– 20% greater left ventricular end systolic volume with the husbandry diet compared to both grain-containing test diets. Concentrations of plasma NT-proBNP were 1.3–2 times greater after the husbandry diet compared to the grain-based diet, with the oligosaccharide and pea-based diets showing intermediate levels. Plasma taurine levels were unchanged across diets, while plasma methionine levels were highest and cysteine/cystine levels were lowest after dogs ate the husbandry diet.DiscussionResults indicate that raffinose in the diet is sufficient, but not required to see an increase NT-proBNP, but did not induce any changes in cardiac function after 5 weeks of feeding. Whether this could progress to reduction in cardiac function with longer term feeding is uncertain. A reduced cardiac function along with the greatest increase in NT-proBNP was observed after feeding the husbandry diet that contained the highest amount of insoluble fiber but did not contain legumes or oligosaccharide. Further research into the impact of insoluble fiber in the dental diet is needed to support these novel observations.
Biocidal effects of a wipe-down procedure using common veterinary cleansers on microbial burden within working canine exterior coats
Authors: Perry Erin B. , Discepolo Dakota R. , Liang Stephen Y. , Scott Maurnice , Williamson Kyleigh , Bender Kelly S. 
Published: July 2023

IntroductionRecent work demonstrating reduction of aerosolized contamination via a wipe-down procedure using common veterinary antiseptics offers promise regarding health concerns associated with cross-contamination from working canines to humans. While mechanical reduction can be achieved via a wipe-down procedure, the biocidal impact on flora within the exterior coat is unknown.MethodologyThis study assessed the biocidal impact of antiseptics on the exterior bacterial community of the canine. Lint-free towels were saturated with 2% chlorhexidine gluconate scrub, or 7.5% povidone-iodine scrub diluted at a 1:4 ratio. Treatments were rotated across the dorsal aspect of kennel housed Foxhounds (n = 30). Sterile swabs were collected in triplicate prior to, and following wipe down, stored in Amies solution at 4°C, plated onto nutrient agar and reduction in colony forming units (CFU) was measured across both treatments. Statistical analysis utilizing PROC GLM examined effects of treatment (p ≤ 0.05). Molecular analysis of the 16S rRNA gene was completed for 3 hounds.ResultsReduction in CFU was measured (p &lt; 0.001) for both antiseptics. Qualitative molecular data indicated that both antiseptics had a biocidal effect on the dominant microbial community on the exterior coat with gram-positive, spore-forming taxa predominating post-treatment.ConclusionEffective wipe-down strategies using common veterinary cleansers should be further investigated and incorporated to safeguard working canine health and prevent cross-contamination of human personnel.
UPAYA PENINGKATAN KESEHATAN PADA BALITA DENGAN PROGRAM BIAN TAHUN 2022
Authors: Dewi Mariza Mustika , Rochkmana Meika Jaya , Astuti Lestari Puji 
Published: July 2023

Pandemi Covid-19 menyebabkan masyarakat dibatasi untuk keluar rumah sehingga menyebabkan ibu yang memiliki balita tidak mengimunisasikan bayinya. Prosentase imunisasi balita semakin menurun semenjak Pandemi Covid-19 dari 99% pada tahun 2020 menjadi 98% di tahun 2021. Kegiatan BIAN yang dilaksanakan di Posyandu Sambiroto dibawah wilayah kerja Puskesmas diharapkan dapat membuat target imunisasi menjadi 100%. Metode yang digunakan dalam kegiatan ini adalah pemberian Imunisasi pada Balita dengan usia 9-59 bulan sesuai dengan jadwal. Hasil yang didapatkan dari kegiatan ini adalah target capaian BIAN di Desa Sambiroto sebesar 100% dengan jumlah balita yang mengikuti imunisasi adalah 75 balita. Kegiatan ini berlangsung lancar dan tertib. Kegiatan ini merupakan upaya peningkatan kesehatan balita dari Penyakit yang Dapat Dicegah Dengan Imunisasi (PD3I) dan membantu melengkapi cakupan imunisasi bayi dan balita di Posyandu Sambiroto Binaan Puskesmas Kedungmundu, Kota SemarangKata Kunci: balita; kesehatan; program bianHEALTH IMPROVEMENT EFFORTS IN TODDLERS WITH THE 2022 BIAN PROGRAMAbstract The Covid-19 pandemic has restricted people from leaving their homes, causing mothers with toddlers to not immunize their babies. The percentage of immunization under five has decreased since the Covid-19 Pandemic from 99% in 2020 to 98% in 2021. The BIAN activities carried out at Sambiroto Posyandu under the Puskesmas work area are expected to make the immunization target 100%. The method used in this activity is immunization for toddlers aged 9-59 months according to the schedule. The results obtained from this activity are the achievement target of BIAN in Sambiroto Village of 100% with the number of children under five taking immunizations is 75 under five. This activity took place smoothly and orderly. This activity is an effort to improve the health of toddlers from Immunization Preventable Diseases (PD3I) and helps complete the coverage of infant and toddler immunizations at the Sambiroto Posyandu Assisted by the Kedungmundu Health Center, Semarang City Keywords: toddler; health; bian program
Children Growth And Development Of 18 Months-Aged Babies: Nutritional Status Overview For Early Stunting Screening
Authors: Apriliyanti Retno , Kustriyanti Dwi 
Published: July 2023

Problems in toddlers include nutrition that can cause malnutrition and stunting. The prevalence of stunting in Indonesia based on the results of the Nutrition Status Monitoring reached 27.5%, while undernourished was 16.29% and underweight babies reached 7.44%. The privilege case in Rowosari, there are 28 children with stunting in 2022. The purpose of this study was to figure out the description of children growth and development at the Rowosari Health Center Semarang for early stunting detection. This type of research was descriptive with a cross-sectional approach. 35 infants under 18 months of age were assessed for nutritional status and stunting by calculating the Z-score and the education and occupation factors of the mother were also analyzed using the chi-square test. The results showed that 5.7% of infants were malnourished and 20% over-nourished, and 17.1% were short and 2.9% were very short. There is a relationship between nutritional status on stunting with p-value <0.05.Keywords: growth; nutritional status; stuntingPertumbuhan Dan Perkembangan Anak Bayi Umur 18 Bulan: Gambaran Status Gizi Untuk Skrining Stunting DiniABSTRAKMasalah pada balita antara lain gizi yang dapat menyebabkan gizi buruk dan stunting. Prevalensi stunting di Indonesia berdasarkan hasil Pemantauan Status Gizi mencapai 27,5%, sedangkan gizi kurang 16,29% dan bayi kurus mencapai 7,44%. Kasus keistimewaan di Rowosari, terdapat 28 anak stunting pada tahun 2022. Tujuan penelitian ini adalah untuk mengetahui gambaran tumbuh kembang anak di Puskesmas Rowosari Semarang untuk deteksi dini stunting. Jenis penelitian ini adalah deskriptif dengan pendekatan cross sectional. 35 bayi berusia di bawah 18 bulan dinilai status gizi dan stuntingnya dengan menghitung Z-score serta faktor pendidikan dan pekerjaan ibu juga dianalisis menggunakan uji chi-square. Hasil penelitian menunjukkan bahwa 5,7% bayi mengalami gizi buruk dan 20% gizi lebih, serta 17,1% bayi pendek dan 2,9% bayi sangat pendek. Ada hubungan antara status gizi dengan stunting dengan p-value < 0,05.Kata kunci: pertumbuhan; status gizi; stunting
Yophytta Exercise to Reduce Hypertension in Pregnant Women
Authors: Wijayanti Heni , Wulandari Dyah Ayu , Brianita Kenri 
Published: July 2023

ABSTRACT Hypertension or high blood pressure due to pregnancy, namely hypertension that occurs due to or during pregnancy, usually occurs at the age of 20 weeks of gestation, which results in morbidity and mortality. Efforts to reduce blood pressure through complementary therapy in pregnant women with hypertension are Yophytta exercise. this study was intended to determine the effect of Yophytta exercise on reducing blood pressure in pregnant women with hypertension int the Paduraksa Health Center area. Methods : research is a quantitative study with a Quasi Experiment method with one group pre test and post test. A sample of 18 respondents using a purposive sampling technique in accordance with the inclusion criteria. The instrument used was Yophytta exercise SOP and the blood pressure observation sheet. Results : of the observations were analyzed using the Wilcoxon Signed Ranks Test. The results of the analysis showed a p value of 0.000 with 0.05, which means that there is a difference in the average blood pressure before and after being given Yophytta exercise. There is an effect of Yophytta exercise on reducing blood pressure in pregnant women with hypertension in the Paduraksa Health Center area. Yophytta exercise can reduce blood pressure in pregnant women with hypertension. Keywords: Yophytta exercise; blood pressure; pregnant women ABSTRAK Hipertensi atau tekanan darah tinggi akibat kehamilan, yaitu hipertensi yang terjadi karena atau selama kehamilan, biasanya terjadi pada usia kehamilan 20 minggu, yang mengakibatkan morbiditas dan mortalitas. Upaya penurunan tekanan darah melalui terapi komplementer pada ibu hamil hipertensi adalah senam Yophytta . Tujuan : untuk mengetahui pengaruh senam Yophytta terhadap penurunan tekanan darah pada ibu hamil dengan hipertensi di wilayah Puskesmas Paduraksa. Metode : penelitian ini merupakan penelitian kuantitatif dengan metode Quasi Experiment dengan one group pre test dan post test. Sampel sebanyak 18 responden dengan menggunakan teknik purposive sampling sesuai dengan kriteria inklusi. Instrumen yang digunakan adalah SOP senam Yophytta dan lembar observasi tekanan darah. Hasil : Hasil observasi dianalisis dengan Wilcoxon Signed Ranks Test. Hasil analisis menunjukkan nilai p sebesar 0,000 dengan 0,05 yang berarti ada perbedaan rata-rata tekanan darah sebelum dan sesudah diberikan senam Yophytta . Ada pengaruh senam Yophytta terhadap penurunan tekanan darah pada ibu hamil hipertensi di wilayah Puskesmas Paduraksa. Senam Yophytta dapat menurunkan tekanan darah pada ibu hamil dengan hipertensi. Kata Kunci: senam Yophytta ; tekanan darah; ibu hamil