bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote care instruction Via the WeChat platform for patients receiving subcutaneous anticoagulation during the COVID-19 pandemic: a retrospective analysis
Authors: Jiang Chao Yun , Li Ci Juan , Zhang Rong , Cai Tian Hong , Zhan Teng Hui 
Published: August 2023

Abstract

Objective
The purpose of this study was to investigate the effect of remote nursing guidance based on WeChat platform for patients receiving subcutaneous anticoagulation during the COVID-19 epidemic.
Methods
Retrospective analysis of clinical data, including demographic data and anticoagulation complications, of 126 patients who received subcutaneous anticoagulation therapy and received remote nursing guidance using WeChat platform in our hospital from January 2022 to December 2022. The Anti-Clot Treatment Scale (ACTS) and the World Health Organization Quality of Life-BREF (WHOQOL-BREF) scale were used to evaluate patients' satisfaction with anticoagulation and quality of life at the beginning of anticoagulation, 2 weeks after anticoagulation, and at the end of anticoagulation.
Results
In total, 126 patients were involved in this study, all of them were female, 115 cases were natural pregnancy, 11 cases were assisted reproduction. This study including 7 cases of lower extremity deep vein thrombosis, 100 cases of hypercoagulable state, 10 cases of antiphospholipid syndrome, and 8 cases of protein S deficiency, 1 case of hyperhomocysteinemia. During the follow-up period, 4 patients (3.17%) had subcutaneous injection complications, including 3 cases of subcutaneous hemorrhage and 1 case of liquid leakage. 123 patients had completed the planned anticoagulation therapy or were receiving anticoagulation therapy as planned, and 3 patients did not receive anticoagulation therapy as planned (0 cases lost contact, 2 cases changed treatment units, and 1 case refused treatment). ACTS score (55.03 ± 1.73) and WHOQOL-BREF score (62.18 ± 3.17) after 3 months of anticoagulation, ACTS score (54.18 ± 1.20) and WHOQOL-BREF score(60.37 ± 2.25) after 2 weeks of anticoagulation was significantly higher than the ACTS score (47.81 ± 1.69) and WHOQOL-BREF score (55.25 ± 1.85) at the beginning of anticoagulation, and the difference was statistically significant (P value<0.01).
Conclusions
During the COVID-19 pandemic, remote nursing instruction via the WeChat platform for patients receiving subcutaneous anticoagulation can increase anticoagulation compliance, satisfaction, and quality of life.
BiGPICC: a graph-based approach to identifying carcinogenic gene combinations from mutation data
Authors: Oles Vladyslav , Dash Sajal , Anandakrishnan Ramu 
Published: August 2023

Abstract
Genome data from cancer patients encapsulates explicit and implicit relationships between the presence of a gene mutation and cancer occurrence in a patient. Different types of cancer in human are thought to be caused by combinations of two to nine gene mutations. Identifying these combinations through traditional exhaustive search requires the amount of computation that scales exponentially with the combination size and in most cases is intractable even for even cutting-edge supercomputers.
We propose a parameter-free heuristic approach that leverages the intrinsic topology of gene-patient mutations to identify carcinogenic combinations. The biological relevance of the identified combinations is measured by using them to predict the presence of tumor in previously unseen samples. The resulting classifiers for 16 cancer types perform on par with exhaustive search results, and score the average of 80.1% sensitivity and 91.6% specificity for the best choice of hit range per cancer type. Our approach is able to find higher-hit carcinogenic combinations targeting which would take years of computations using exhaustive search.
Blow-up and global existence of solutions to degenerate Kirchhoff equation with variable source
Authors: Zhang Jingjing , Li Xiaolei 
Published: August 2023

Abstract

In this paper, we mainly studies the classification of global existence and blow-up of solutions to degenerate Kirchhoff problems for the initial energy at different conditions. Firstly, under subcritical or critical conditions, we find two invariant sets and obtain the threshold results of global existence or blow-up in finite time. Furthermore, we apply $\omega$-limit to prove the existence of blow-up solutions for the supercritical initial energy case. Finally, we give two-sided estimates of asymptotic behavior when the source term is controlled by the diffusion term.
Mathematics Subject Classification (2010). Primary 35K55, 35B40; Secondary 35B44.
How stable are moral judgements? A longitudinal study of context dependency in attitudes towards patient responsibility
Authors: Bringedal Berit H , Rø Karin Isaksson 
Published: August 2023

Abstract
Background
Whether patients' life-style should involve lower priority for treatment is a controversial question in bioethics. Less is known about clinicians' views.
Methods
Surveys of doctors in Norway in 2008, 2014, 2021. Questionnaires included statements about patients' lifestyle's significance for priority to care, and vignettes of priority cases (only 2014). Focus group with six GPs in 2019. Data analysed by descriptive statistics, linear regression, and text analysis.
Results
Attitudes were fairly stable between 2008 and 2021. 17%/14% agreed that patients' lifestyle should count, while 19%/22% agreed that it should involve lower priority to scarce organs. 42/44% agreed that smokers should have lower priority. Substantially more agreed in 2014. Regression analyses showed that being male, working in hospital, and younger age increased the likelihood of agreeing. The focus group interview demonstrated that "lower priority" was unclear, and that attitudes changed from more to less positive to lowering priority due to lifestyle during discussion.
Conclusion
Many doctors agreed that lifestyle should be a priority criterion, contrary to Norwegian legislation and professional ethics. This might be explained by the unspecified meaning of priority, increased scarcity-awareness, or socio-cultural trends towards individualism. The 2014 results indicate a framing effect; the vignettes may have primed the respondents towards accepting lifestyle as a criterion. The interview demonstrated that moral views are changeable. Three lessons are drawn: Attitudes to normative questions are unstable and depend on context. The practical implication of "lower priority" should be specified. Many doctors are positive to deprioritizing patients allegedly responsible for their illness.
Clinical phenotypic characteristics of heart failure with preserved ejection fraction and its influence on prognosis
Authors: Xu Xia , Wang Yajiao , Li Yumeng , Zhang Bingxuan , song qingqiao 
Published: August 2023

Abstract
Background
Patients with heart failure with preserved ejection fraction are characterized by high morbidity and poor prognosis. Previous studies have shown that there are several different phenotypes of HFpEF, each with distinct clinical features, and we used k-means clustering to determine the clinical phenotypes of patients with HFpEF and to investigate their impact on prognosis.
Methods
We first screened 189 patients with HFpEF who met the inclusion criteria and stratified them using K-mean clustering according to clinical characteristics, routine blood and biochemical parameters, echocardiography, and comorbidities, and determined the optimal number of prime hearts using the error sum of squares. Kaplan-Meier survival curves were then used to assess the impact of each clinical phenotype on all-cause mortality; Cox regression risk models were used to estimate the correlation between each clinical phenotype and long-term prognosis.
Results
Four HFpEF phenotypes were identified: phenotype 1 was a young patient with poor cardiac function but preserved renal function; phenotype 2 was an older male patient with cardiac and renal insufficiency; phenotype 3 had preserved LA morphology and function, and all patients in this group had higher ejection fractions than the other three groups; phenotype 4 was an older female patient with preserved cardiac function but poor renal function. The Kaplan-Meier survival analysis found that patients with phenotype 2 had significantly lower survival rates than the other three groups, and the Cox proportional risk analysis also found that phenotype 2 showed the highest risk of all-cause mortality (HR = 4.6094; 95% CI: 2.0373, 10.4291).
Conclusion
K-means cluster analysis classified HFpEF patients into four clinical phenotypes, and the analysis revealed that old age and renal insufficiency were decisive factors affecting prognosis, so the staging and treatment of HFpEF patients should focus on age and renal function.
Argininosuccinate Lyase (ASL) Deficiency; Outcome of Patients with an Early Presentation at Johns Hopkins Aramco Healthcare (JHAH)
Authors: Alhaidar Atheer , AlSannaa Nouriya 
Published: August 2023

Abstract
Argininosuccinic aciduria (ASA) is an autosomal recessive inborn error of the urea disorder (UCD) cycle caused by mutation in the gene encoding argininosuccinate lyase (ASL). Here, we describe long-term complications and outcome of twelve Saudi Arab patients originated from four unrelated families diagnosed with ASA from January 1st 1983 to December 31st 2022 within Johns Hopkins Aramco Healthcare (JHAH). The age distribution was from 1 to 29 years with an average of 11.9. All patients manifested the classic severe neonatal phenotype. Despite of an early diagnosis, immediate medical intervention and good metabolic control, all the patients displayed variable degrees of cognitive impairment and neurologic dysfunction. Developmental delay and seizures disorder were seen in all of the affected patients. Other observed neuropsychiatric disorders were attention deficit hyperactivity and sleeping disorders. The previously recognized c.1060C > Tp(Q354X) genotype in Saudi Arab population was found to be associated with intractable seizures and psychomotor regression. This cohort study supports the former reports of high rate of neurologic complication in Argininosuccinate lyase deficiency contrasting with a lower rate of hyperammonemia.
The Impact of Digital Inequities on Esophageal Cancer Disparities in the US
Authors: Fei-Zhang David J. , Edwards Evan R. , Asthana Shravan , Chelius Daniel C , Sheyn Anthony M. , Rastatter Jeffrey C. 
Published: August 2023

Abstract
Objectives: To develop and implement a novel, comprehensive tool called the Digital Inequity Index (DII) that quantifiably measures modern technology access in the US and to assess the impact of digital inequity on esophageal cancer (EC) care nationwide.
Methods: A total of15,656 EC patients from 2013-2017 in SEER were assessed for significant regression trends in long-term follow-up, survival, prognosis, and treatment with increasing overall digital inequity, as measured by the DII. The DII was calculated based on 17 censustract-level variables derived from the American Community Survey and Federal Communications Commission. Variables were categorized as infrastructure-access (i.e., electronic device ownership, type of broadband, internet provider availability, income-broadband subscription ratio) or sociodemographic (i.e.,education, income, disability status), ranked and then averaged into a composite score.
Results: With increasing overall digital inequity, significant decreases in the length of long-term follow-up (p<0.001) and survival (p<0.001) for EC patients were observed. EC patients showed decreased odds of receivingthe indicated surgical resection (OR 0.90, 95% CI 0.84-96; OR 0.97; 95% CI0.95-1.00, respectively) with increasing digital inequity. They also showed increased odds of advanced preliminary staging (OR 1.02, 95% CI 1.00-1.05) and decreased odds of receiving the indicated chemotherapy (OR 0.97; 95% CI 0.95-99).
Conclusions: Digital inequities meaningfully contribute to detrimental trends in EC patient care in the US, allowing discourse for targeted means of alleviating disparities while contextualizing national, sociodemographic trends of the impact of online access on informed care.
Level of Evidence: III
Solid‒liquid separation and its environmental impact on manure treatment in scaled pig farms - Based on life cycle assessment
Authors: Zhang Yijia , Bo Qinqing , Du Yating , Du Xinyi , Xu Liyang , Yang Yadong 
Published: August 2023

Abstract
Recently, there has been a significant focus on the issue of pollution caused by livestock and poultry rearing, which is recognized as a prominent contributor to nonpoint source pollution in the agricultural sector. This study employed the life cycle assessment (LCA) methodology to evaluate the environmental impact of several pig manure processing scenarios, with the aim of determining the appropriate solid‒liquid separation tool for large-scale pig farms. The findings indicate that the utilization of a screw extruder for solid‒liquid separation in scenario 2 has a lower environmental impact. In contrast to scenario 1, scenario 2 exhibits reduced environmental potential in the areas of global warming, human toxicity, acidification, and eutrophication. Specifically, the global warming, human toxicity, acidification, and eutrophication impacts decreased by 56%, 81%, 83%, and 273%, respectively, due to the implementation of solid‒liquid separation. The type of solid‒liquid separation equipment used during the processing of swine manure, as well as the subsequent treatment, have a significant impact on environmental emissions. Compared to scenario 2, scenario 3, which utilizes a centrifugal microfilter for solid‒liquid separation, exhibits a lower environmental impact in terms of human toxicity, resulting in a reduction of 0.736 kg DCB-eq. In general, solid‒liquid separation is a viable environmentally friendly method for the disposal of waste from large-scale pig farms. The adoption of this method is highly recommended. During its implementation, careful consideration should be given to factors such as separation efficiency and pollution emissions. It is crucial to select appropriate equipment for solid‒liquid separation to effectively process the waste.
A Formal validation of an Entropy-based Artificial Intelligence for Ultrasound Data in Breast Tumors
Authors: Huang Zhibin , Yang Keen , Tian Hongtian , Wu Huaiyu , Tang Shuzhen , Cui Chen , Shi Siyuan , Jiang Yitao , Chen Jing , Xu Jinfeng , Dong Fajin 
Published: August 2023

Abstract
Background: Research on artificial intelligence-assisted breast diagnosis is mainly based on static images or dynamic videos. The acquired images or videos may come from ultrasound probes of different frequencies. It is not clear how frequency-induced image variations affect the diagnosis of artificial intelligence models.
Purpose: To explore the impact of using ultrasound images of variable frequencies on the diagnostic efficacy of artificial intelligence in breast ultrasound screening.
Materials and Methods: Video and entropy-based, using a feature entropy breast network compared the diagnostic performance and average two-dimensional image entropy of the L14-L9 linear array probe and L13-L7 linear array probe.
Results: In testing set 1, the diagnostic efficiency of the L9 dataset is better than L14; In testing set 2, the diagnostic efficiency of the L13 dataset is better than L7; the value of L9, L13 dataset is greater than L14, L7dataset in the average two-dimensional image entropy, respectively.
Conclusion: Ultrasound images obtained with a certain degree of lower frequency probes have a higher average two-dimensional image entropy, which is beneficial for the diagnosis of artificial intelligence models. The higher the average two-dimensional image entropy of the dataset, the superior its diagnostic performance.
Curvature and Chaos in the Defocusing Parameteric Nonlinear Schrödinger System
Authors: Promislow Keith , Ramadan Abba 
Published: August 2023

Abstract
The parametric nonlinear Schrödinger equation models a variety of parametrically forced and damped dispersive waves. For the defocusing regime, we derive a normal velocity for the evolution of curved dark-soliton fronts that represent a π-phase shift across a thin interface. We establish a simple mechanism through which the parametric term transitions the normal velocity evolution from a curvature driven flow to motion against curvature regularized by surface diffusion of curvature. In the former case interfacial length shrinks, while in the later the interface length generically grows until self-intersection followed by a transition to chaotic motion.
Association between the COMMD1 gene polymorphism rs11125908 and rheumatoid arthritis in the Cuban population
Authors: Alvarez Maidel Carpio , Benitez Alberto Cintado , Argudin Tamara Diaz , Cuni Hugo Nodarse , Horta Maria del Carmen Dominguez , Massó Julio Raúl Fernández 
Published: August 2023

Abstract
Introduction: COMMD1 is a pleiotropic protein that is involved in NF-kB regulation. NF-kB signaling is relevant for the evolution and treatment of RA. The minor allele G of the polymorphism rs11125908 in Commd1 has been associated with a higher expression of COMMD1 and a decrease in bone erosions in Japanese patients. Objectives: To evaluate the association of the rs11125908 polymorphism in the Cuban population with RA and its association with important clinical variables. Methods: Allele specific-PCR was used to genotype 150 controls and 161 cases. Association statistical analysis was conducted by adjusting for age and sex using SNPStats. Results: An association of the SNP with the disease was found in overdominant model (P = 0.025; OR = 1.91) for the AG genotype. Our analyses revealed a significant association between rs11125908 and the subgroup of patients with swollen joints < median under codominant model for A/G (P = 0.034; OR = 2.30) and GG genotype (P = 0.034; OR = 0.82) and with the overdominant model (P = 0.01; OR = 2.38). The subgroup of patients with the age of onset lower than the mean, the AG genotype showed association in the overdominant model (P = 0.027; OR = 2.27). DAS28 and Time of disease evolution variables were not associated with the rs11125908 polymorphism. Conclusions: The rs11125908 polymorphism may be associated with RA. In particular, rs11125908 was significantly associated with RA and also in the number of swollen joints and age of onset subgroup analyses. Our study may provide new concepts for individualized treatments of RA based on pharmacological management of COMMD1 expression.
Comprehensive analysis of immunogenic cell death-related gene and construction of prediction model based on WGCNA and multiple machine learning in severe COVID-19
Authors: Li Chunyu , wu ke , yang rui , Liao Minghua , Li Jun , Zhu Qian , Zhang Jiayi , Zhang Xianming 
Published: August 2023

Abstract
Severe Acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease with a high mortality rate. The death of coronavirus disease 2019 (COVID-19) is primarily due to from critically ill patients, especially from ARDS complications caused by SARS-CoV-2. Therefore, it is essential to contribute an in-depth understanding of the pathogenesis of the disease and to identify biomarkers for predicting critically ill patients at the molecular level, and thereby reduce COVID-19 mortality. Immunogenic cell death (ICD), as a specific variant of regulatory cell death driven by stress, can induce adaptive immune responses against cell death antigens in the host. Studies have confirmed that both innate and adaptive immune pathways are involved in the pathogenesis of SARS-CoV-2 infection. In severe COVID-19 patients, a large number of inflammatory mediators are released and cell death occurs, which leads to immune disorders. However, the role of ICD in the pathogenesis of severe COVID-19 has rarely been explored. In this study, we systematically evaluated the role of ICD-related genes in COVID-19. The differential expression of ICD-related genes in COVID-19 samples and healthy control samples, as well in ICU samples and Non-ICU samples were respectively explored. We conducted consensus clustering, immune infiltration analysis, and functional enrichment analysis based on ICD differentially expressed genes. The results showed that immune infiltration characteristics were altered in severe and non-severe COVID-19. In addition, we used multiple machine learning methods to screen for five risk genes (KLF5, BICDL1, APH1B, GRB10, and OLAH), which are used to predict COVID-19 severity. Finally, we constructed a nomogram to predict the risk of severe COVID-19 based on the classification and recognition model, and validated the model with external data sets. This study provides a valuable direction for the exploration of the pathogenesis and progress of COVID-19, and helps in the early identification of severe cases of COVID-19 to reduce mortality.
The causal effect of hypertension, intraocular pressure, and diabetic retinopathy: A Mendelian Randomization study
Authors: wang xiaofang , zhang xiaowen , liu yajun , zheng xinyu , su mengru , sun xinghong , jiang feng , liu zhinan 
Published: August 2023

Abstract
Background: Previous research has indicated a vital association between hypertension, intraocular pressure (IOP), and diabetic retinopathy (DR), however, the relationship has not been elucidated. In this study we aim to investigate the causal association of hypertension, intraocular pressure, and diabetic retinopathy.
Methods: The Genome-wide association study (GWAS) IDs for DR and hypertension and IOP were identified from the Integrative Epidemiology Unit (IEU) Open GWAS database. There were 33,519,037 SNPs and a sample size of 1,030,836 for DR. There were 16,380,466 single nucleotide polymorphisms (SNPs) and 218,754 participants in the hypertension experiment. There were 9,851,867 SNPs and a sample size of 97,465 for IOP. Univariable and multivariable Mendelian randomization (MR) study was conducted to estimate the risk of hypertension and IOP in DR. Moreover, causality was examined using the inverse variance weighted method, and MR results were verified by numerous sensitivity analyses.
Results: A total of 62 SNPs at the genome-wide significance level were selected as instrumental variables (IVs) for hypertension-DR. The results of univariable MR analysis suggested a causal relationship between hypertension and DR and regarded hypertension as a risk factor for DR (P=0.006, odds ratio (OR) =1.081). A total of 94 SNPs at the genome-wide significance level were selected as IVs for hypertension-DR. Similarly, IOP was causally associated with DR and was a risk factor for DR (P=0.0292, OR=1.0922). The results of multivariate MR analysis revealed that hypertension and IOP were risk factors for DR, which exhibited higher risk scores (P=0.001, OR=1.121 and P=0.030, OR=1.124, respectively) than those in univariable MR analysis. Therefore, hypertension remained a risk factor for DR after excluding the interference of IOP, and IOP was still a risk factor for DR after excluding the interference of hypertension.
Conclusion: This study validated the potential causal relationship between hypertension, IOP, and DR using MR analysis, providing a reference for the targeted prevention of DR.