bluuebunny/crossref_metadata_2025_split huggingface dataset:
TheSLC1A1/EAAT3 Dicarboxylic Amino Acid Transporter is an Epigenetically Dysregulated Nutrient Carrier that Sustains Oncogenic Metabolic Programs
Authors: Grubb Treg , Khatun Jesminara , Matar Sayed , Ghandour Fatme , Dubasik Noah , Salem Carleigh , Orlando David A. , Guenther Matthew G. , Martinez Steven R. , Koochaki Pooneh , Coker Jesse A. , Tang Cerise , Reznik Eduard , Kotecha Ritesh R. , Hakimi A. Ari , Abdallah Nour , Weight Christopher J. , Choueiri Toni K. , Asara John M. , Stauffer Shaun R. , Signoretti Sabina , Kaelin William G. , Chakraborty Abhishek A. 
Published: September 2023

ABSTRACTInactivation of pVHL tumor suppressor in clear cell Renal Cell Carcinoma (ccRCC) increases the abundance of Histone H3 lysine 27 acetylation (H3K27ac). We hypothesized that H3K27ac, a marker of transcriptional activation, drives the expression of critical oncogenes in ccRCC. Using H3K27ac ChIP-Seq; RNA-Seq; anin vivopositive selection screen; cell-based functional studies; and clinical validations; here, we report the identification of the SLC1A1/EAAT3 aspartate (Asp) and glutamate (Glu) transporter as a ccRCC oncogene. pVHL loss promotes SLC1A1 expression in a HIF-independent manner. Importantly, SLC1A1 inactivation depletes Asp/Glu-derived metabolites, impedes ccRCC growth bothin vitroandin vivo, and sensitizes ccRCCs to metabolic therapeutics (e.g., glutaminase blockers). Finally, in human ccRCC biospecimens, higher SLC1A1 expression is associated with metastatic disease and clusters with elevated expression of other solute carriers, but not HIF/Hypoxia pathways. Altogether, our studies identify a HIF-independent metabolic hub in ccRCC and credential SLC1A1 as an actionable ccRCC oncogene.STATEMENT OF SIGNIFICANCETargeting chronic HIF activation underlies many therapeutic strategies in ccRCC; but, unfortunately, is not curative. SLC1A1, instead, represents a HIF-independent ccRCC dependency, which is targetable alone and together with other antimetabolites, such as glutaminase inhibitors. These observations identify an actionable metabolic program that functions independent of HIF in ccRCC.
Overexpression ofZmSTOP1-AEnhances Aluminum Tolerance in Arabidopsis by Stimulating Organic Acid Secretion and Reactive Oxygen Species Scavenging
Authors: Liu Chan , Hu Xiaoqi , Zang Lei , Liu Xiaofeng , Wei Yuhui , Wang Xue , Jin Xinwu , Du Chengfeng , Yu Yan , He Wenzhu , Zhang Suzhi 
Published: September 2023

AbstractAluminum (Al) toxicity and low pH are major factors limiting plant growth in acidic soils. Sensitive to Proton Rhizotoxicity 1 (STOP1) transcription factor respond to these stresses by regulating the expression of multiple Al- or low pH-responsive genes. ZmSTOP1-A, a STOP1-like protein from maize (Zea mays), was localized to the nucleus and had transactivation activity.ZmSTOP1-Awas expressed moderately in both roots and shoots of maize seedlings, but was not induced by Al stress or low pH. Overexpression ofZmSTOP1-Ain ArabidopsisAtstop1mutant partially restored Al tolerance and completely low pH tolerance with respect to root growth. Regarding Al tolerance,ZmSTOP1-A/Atstop1plants showed clear upregulation of organic acid transporter genes, and leading to increased organic acid secretion and reduced Al accumulation in roots. Besides, the antioxidant enzyme activity in roots and shoots ofZmSTOP1-A/Atstop1plants was significantly enhanced, ultimately alleviating Al toxicity via scavenging reactive oxygen species. Similarly, ZmSTOP1-A could directly activateZmMATE1expression in maize, positively correlated with the number of Al-responsive GGNVScis-element in theZmMATE1promoter. Our results revealed that ZmSTOP1-A antagonizes Al toxicity by enhancing organic acid secretion and reactive oxygen species scavenging in Arabidopsis, demonstrating that it is an important transcription factor conferring Al tolerance. Our findings help to comprehensively elucidate the role of STOP1-like transcript factor in enabling plants to detoxifying Al.
Creating the baseline: data relations and frictions of UK City of Culture evaluation
Authors: Ashton Daniel , Gowland-Pryde Ronda , Roth Silke , Sturt Fraser 
Published: September 2023

PurposeSocioeconomic aims and impacts are an explicit part of the UK City of Culture (UKCoC) application, bidding, delivery and evaluation stages. This article engages with existing debates on evaluating cities of culture and introduces perspectives from critical data studies to examine the collection and analysis of different data for the purposes of the CoC application and evaluation processes.Design/methodology/approachThe meta-methodological concept of accompanying researcher is used to analyse the experiences of researchers based within a city bidding for UKCoC 2025 in dialogue with the evaluation reports from past UKCoC host cities.FindingsFindings are analysed under three themes: defining data morsels; local histories and infrastructures of data generation and sharing; and resources, capacities and expertise for data generation and evaluation. The discussion examines data still to be generated and/or brought into relation; tensions around data and measurement; and how constructing an evaluation baseline is generative—creating new organisations, relationships and practices.Practical implicationsThe conceptual and methodological approach and empirical findings will be relevant for academic, policymakers and practitioners engaging with cultural evaluation.Originality/valueIn focussing on the bidding stage in real time through the accompanying researcher position, this article presents original empirical insights into the process of creating a baseline for cities of culture evaluation. The conceptual originality of this article is in using critical data studies to explain strategies of data generation and analyse data relations and frictions.
Resilience strategies to mitigate “extreme” disruptions in sustainable tourism supply chain
Authors: Chowdhury Md Maruf Hossan , Mahmud A.K.M. Shakil , Banik Shanta , Rabbanee Fazlul K. , Quaddus Mohammed , Alamgir Mohammed 
Published: September 2023

PurposeDrawing on the dynamic capability view (DCV), this research determines the suitable configurations of resilience strategies for sustainable tourism supply chain performance amidst “extreme” disruptive events affecting the entire supply chain.Design/methodology/approachThis research applies a multi-study and multi-method approach. Study 1 utilizes in-depth interviews to identify a list of tourism supply chain sustainability risks and resilience strategies. Study 2, using quality function deployment (QFD) technique, determines the most important resilience strategies corresponding to highly significant risks. Study 3, on the other hand, adopts a fuzzy set qualitative comparative analysis (fsQCA) to determine the best recipe of resilience strategies and risks to make the tourism supply chain performance sustainable.FindingsThe findings reveal that sustainable tourism performance during an extreme disruptive event (e.g. COVID-19 health crisis) depends on the combined effect of tourism resilience strategies and risks instead of their individual effect.Practical implicationsThe research findings offer significant managerial implications. Managers may experiment with multiple causal conditions of risks and resilience strategies to engender the expected outcome.Originality/valueThis research extends current knowledge on tourism supply chain and offers insights for managers to mitigate the risks and ensures sustainable performance in the context of extreme disruptive events.
Sustainable Development Goals and the future of architectural education – cultivating SDGs-centred architectural pedagogies
Authors: Burton Lindy Osborne , Salama Ashraf M. 
Published: September 2023

PurposeFollowing the positive call for a special issue on Architectural Pedagogies and Sustainable Development Goals (SDGs), the purpose of this overview article is to contextualise reflections on nine selected articles, within recent efforts made by professional organisations, which aspire to blend sustainable development into the collective psyche of both academics and future professionals.Design/methodology/approachThis article adopts four lines of inquiry by capturing key insights on the place of sustainable design knowledge in architectural education validation and accreditation at both national and global scales; presenting analytical narratives on the recent global efforts that embrace excellence in architectural pedagogy through addressing SDGs; elucidating the two knowledge spaces, centred on pedagogy and sustainability, which are strengthened and supported by Archnet-IJAR, and offering reflections on the nine articles published in this special issue that aims at integration of the two knowledge spaces.FindingsContextualisation and reflective narratives offer insights into current efforts and demonstrate a clear commitment of professional organisations to embed values relevant to SDGs. Efforts of the Education Commission of the International Union of Architects and the UNESCO-UIA Validation Council of Architectural Education appear to have advanced significantly over recent years with a clear prospect for a sustainable future. The nine articles published in this special issue respond clearly to the goal of Quality Education (SDG4), but not all of them have addressed the goals related to Good Health and Well-being (SDG3) and Sustainable Cities and Communities (SDG11), and their place in architectural pedagogy. However, they take a step further to address aspects of climate change, globalisation, sustainable architecture and urbanism, social sustainability, global north/global south dialectics and decolonisation.Practical implicationsThe findings offer opportunities to recognise efforts by professional organisations, map key pedagogical experiments into these efforts, while providing lessons learned from best practices aiming to effectively integrate SDGs into architectural pedagogy.Originality/valueNo serious effort has been made to articulate the integration of SDGs into architectural education at the level of research or design studio pedagogical practice. Addressing architectural pedagogies and sustainable development is predicated on the fact that there is very little written or known on integrating SDGs into architectural education and design pedagogy. Understanding, appreciating, and sharing various efforts and approaches to incorporate SDGs into architectural pedagogy is a key step towards a sustainable future.
Toward a simple topological model of a three-phase transformer including deep saturation conditions
Authors: Zirka Sergey E. , Albert Dennis , Moroz Yuriy I. , Domenig Lukas Daniel , Schürhuber Robert 
Published: September 2023

Purpose
This paper aims to propose a method of parametrizing topological transformer model at high flux densities in the core.

Design/methodology/approach
The approach proposed is based on terminal voltages and currents measured in a special purpose saturation test whose data are combined with typical saturation curves of grain-oriented electrical steels; the modeling is carried out in the ATPDraw program.

Findings
The authors corroborate experimentally the necessity of dividing the zero sequence impedance between all transformer phases and propose a method of the individual representation of the legs and yokes. This eliminates the use of nonexistent leakage inductances of primary and secondary windings.

Practical implications
The presented modeling approach can be used for predicting inrush current events and in the evaluation of the impact caused by geomagnetically induced currents (GICs).

Originality/value
The proposed approach is completely original and will contribute to a better understanding of the transients occurring in a transformer under abnormal conditions, such as inrush current events and GICs.
Geometry reconstruction based on arc splines with application to wheel-rail contact simulation
Authors: Silva Lucas , Gay Neto Alfredo 
Published: September 2023

PurposeWhen establishing a mathematical model to simulate solid mechanics, considering realistic geometries, special tools are needed to translate measured data, possibly with noise, into idealized geometrical entities. As an engineering application, wheel-rail contact interactions are fundamental in the dynamic modeling of railway vehicles. Many approaches used to solve the contact problem require a continuous parametric description of the geometries involved. However, measured wheel and rail profiles are often available as sets of discrete points. A reconstruction method is needed to transform discrete data into a continuous geometry.Design/methodology/approachThe authors present an approximation method based on optimization to solve the problem of fitting a set of points with an arc spline. It consists of an initial guess based on a curvature function estimated from the data, followed by a least-squares optimization to improve the approximation. The authors also present a segmentation scheme that allows the method to increment the number of segments of the spline, trying to keep it at a minimal value, to satisfy a given error tolerance.FindingsThe paper provides a better understanding of arc splines and how they can be deformed. Examples with parametric curves and slightly noisy data from realistic wheel and rail profiles show that the approach is successful.Originality/valueThe developed methods have theoretical value. Furthermore, they have practical value since the approximation approach is better suited to deal with the reconstruction of wheel/rail profiles than interpolation, which most methods use to some degree.
Influencing factors on building and improving social trust in emergency and disaster relief efforts: a systematic review
Authors: Khankeh HamidReza , Farrokhi Mehrdad , Saatchi Mohammad , Pourebrahimi Mohammad , Roudini Juliet , Rahmatali Khazaee Amin , Jenabi Ghods Mariye , Sepahvand Elham , Ranjbar Maryam , Hosseinabadi-Farahani Mohammadjavad 
Published: September 2023

Purpose
This study aims to review the results of relevant studies to shed light on social trust-building in different contexts and the factors that affect it in disaster risk management.

Design/methodology/approach
This systematic review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses model. The study keywords were searched for in PubMed, Scopus and Web of Science databases on August 2021. The inclusion criteria were English-written articles published in social trust and disaster relief efforts. Exclusion criteria were lack of access to the full text and article types such as nonoriginal articles.

Findings
Out of 1,359 articles found, 17 articles were included in the final analysis using four general categories: six articles on the role of local government in trust-building (local governments), five articles on the role of social media in trust-building (social media), four articles on the role of social capital in trust-building (social capital) and two articles on the importance of community participation in trust-building (community participation).

Originality/value
Understanding the role of social trust and the factors which influence it will help the development of community-based disaster risk management. Therefore, disaster management organizations and other relief agencies should take the findings of this study into account, as they can help guide policymaking and the adoption of strategies to improve public trust and participation in comprehensive disaster risk management. Further studies recommended understanding people’s experiences and perceptions of social trust, relief and disaster preparedness.
European emergency managers on social media: institutional arrangements and guidelines
Authors: Torpan Sten , Hansson Sten , Orru Kati , Rhinard Mark , Savadori Lucia , Jukarainen Pirjo , Nævestad Tor-Olav , Meyer Sunniva Frislid , Schieffelers Abriel , Lovasz Gabriella 
Published: September 2023

PurposeThis paper offers an empirical overview of European emergency managers' institutional arrangements and guidelines for using social media in risk and crisis communication.Design/methodology/approachThe authors collected and analysed material including publicly accessible relevant legal acts, policy documents, official guidelines, and press reports in eight European countries – Germany, Italy, Belgium, Sweden, Hungary, Finland, Norway, and Estonia. Additionally, the authors carried out 95 interviews with emergency managers in the eight countries between September 2019 and February 2020.FindingsThe authors found that emergency management institutions' social media usage is rarely centrally controlled and social media crisis communication was regulated with the same guidelines as crisis communication on traditional media. Considering this study's findings against the backdrop of existing research and practice, the authors find support for a “mixed arrangement” model by which centralised policies work in tandem with decentralised practices on an ad hoc basis.Practical implicationsComparative insights about institutional arrangements and procedural guidelines on social media crisis communication in the studied countries could inform the future policies concerning social media use in other emergency management systems.Originality/valueThis study includes novel, cross-national comparative data on the institutional arrangements and guidelines for using social media in emergency management in the context of Europe.
A reliability-based design and optimization strategy using a novel MPP searching method for maritime engineering structures
Authors: Yang Shiyuan , Meng Debiao , Guo Yipeng , Nie Peng , Jesus Abilio M.P. de 
Published: September 2023

PurposeIn order to solve the problems faced by First Order Reliability Method (FORM) and First Order Saddlepoint Approximation (FOSA) in structural reliability optimization, this paper aims to propose a new Reliability-based Design Optimization (RBDO) strategy for offshore engineering structures based on Original Probabilistic Model (OPM) decoupling strategy. The application of this innovative technique to other maritime structures has the potential to substantially improve their design process by optimizing cost and enhancing structural reliability.Design/methodology/approachIn the strategy proposed by this paper, sequential optimization and reliability assessment method and surrogate model are used to improve the efficiency for solving RBDO. The strategy is applied to the analysis of two marine engineering structure cases of ship cargo hold structure and frame ring of underwater skirt pile gripper. The effectiveness of the method is proved by comparing the original design and the optimized results.FindingsIn this paper, the proposed new RBDO strategy is used to optimize the design of the ship cargo hold structure and the frame ring of the underwater skirt pile gripper. According to the results obtained, compared with the original design, the structure of optimization design has better reliability and stability, and reduces the risk of failure. This optimization can also better balance the relationship between performance and cost. Therefore, it is recommended for related RBDO problems in the field of marine engineering.Originality/valueIn view of the limitations of FORM and FOSA that may produce multiple MPPs for a single performance function, the new RBDO strategy proposed in this study provides valuable insights and robust methods for the optimization design of offshore engineering structures. It emphasizes the importance of combining advanced MPP search technology and integrating SORA and surrogate models to achieve more economical and reliable design.
External knowledge and eco-innovation: evidence from small and medium-sized enterprises
Authors: Edeh Jude , Vinces Jesús-Peña 
Published: September 2023

Purpose
Firms are engaging in eco-innovation as a response to environmental concerns. Due to its complexity, firms are searching, absorbing and using externally acquired knowledge toward implementing eco-innovation. Thus, this study aims to examine how different external knowledge sources affect the eco-innovation of small and medium-sized enterprises (SMEs) in developing economies.

Design/methodology/approach
The study uses an Ordered Probit regression analysis for 318 developing economy SMEs to examine the impact of vertical flows (suppliers and customers) and horizontal flows (competitors and scientific organisations) on eco-innovations.

Findings
On the vertical dimension, the results show that external knowledge from suppliers is positively associated with eco-product and eco-process innovations. However, external knowledge from customers is positively associated with eco-product innovation, but not eco-process innovation. On the horizontal dimension, external knowledge from competitors contributes to eco-process innovation, but not to eco-product innovation. Finally, external knowledge from scientific organizations is positively related to eco-product and eco-process innovations.

Originality/value
First, the study contributes to the external knowledge literature by focusing on developing country SMEs. Second, the methodology used in this study constitutes a novelty as it provides a tool that categorizes firms according to the extent of emphasis they placed on both eco-product and eco-process innovations. Finally, it offers new evidence by revealing that the effects of external knowledge on eco-innovations are differentiated and not equally beneficial to firms.
Forecasting expenditure components in Nigeria
Authors: Salisu Afees , Omotor Douglason Godwin 
Published: September 2023

PurposeThis study forecasts the government expenditure components in Nigeria, including recurrent and capital expenditures for 2021 and 2022, based on data from 1981 to 2020.Design/methodology/approachThe study employs statistical/econometric problems using the Feasible Quasi Generalized Least Squares approach. Expenditure forecasts involve three simulation scenarios: (1) do nothing where the economy follows its natural path; (2) an optimistic scenario, where the economy grows by specific percentages and (3) a pessimistic scenario that defines specific economic contractions.FindingsThe estimation model is informed by Wagner's law specifying a positive link between economic activities and public spending. Model estimation affirms the expected positive relationship and is relevant for generating forecasts. The out-of-sample results show that a higher proportion of the total government expenditure (7.6% in 2021 and 15.6% in 2022) is required to achieve a predefined growth target (5%).Originality/valueThis study offers empirical evidence that specifically requires Nigeria to invest a ratio of 3 to 1 or more in capital expenditure to recurrent expenditure for the economy to be guided on growth.