bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombectomy with or without Intravenous Thrombolytics in Basilar Artery Occlusion
Authors: Maïer Benjamin , Finitsis Stephanos , Mazighi Mikael , Lapergue Bertrand , Marnat Gaultier , Sibon Igor , Richard Sebastien , Cognard Christophe , Viguier Alain , Olivot Jean‐Marc , Gory Benjamin ,   the ETIS Registry Investigators
Published: June 2023

ObjectiveTwo randomized trials demonstrated the benefit of endovascular therapy (EVT) in patients suffering from a stroke due to a basilar artery occlusion (BAO). However, intravenous thrombolytic (IVT) use before EVT was low in these trials, questioning the added value of this treatment in this setting. We sought to investigate the efficacy and safety of EVT alone compared to IVT + EVT in stroke patients with a BAO.MethodsWe analyzed data from the Endovascular Treatment in Ischemic Stroke registry, a prospective, observational, multicenter study of acute ischemic stroke patients treated with EVT in 21 centers in France between 1 January 2015 and 31 December 2021. We included patients with BAO and/or intracranial vertebral artery occlusion and compared patients treated with EVT alone versus IVT + EVT after propensity score (PS) matching. Variables selected for the PS were pre‐stroke mRS, dyslipidemia, diabetes, anticoagulation, admission mode, baseline NIHSS and ASPECTS, type of anesthesia, and time from symptom onset to puncture. Efficacy outcomes were good functional outcome (modified Rankin Scale [mRS] 0‐3) and functional independence (mRS 0–2) at 90 days. Safety outcomes were symptomatic intracranial hemorrhages and all‐cause mortality at 90 days.ResultsAmong 385 patients, 243 (134 EVT alone and 109 IVT + EVT) were included after PS matching. There was no difference between EVT alone and IVT + EVT regarding good functional outcome (adjusted odd ratio [aOR] labeling = 1.27, 95% confidence interval [CI], 0.68–2.37, p = 0.45) and functional independence (aOR = 1.50, 95% CI, 0.79–2.85, p = 0.21). Symptomatic intracranial hemorrhage and all‐cause mortality were also similar between the two groups (aOR = 0.42, 95% CI, 0.10–1.79, p = 0.24 and aOR = 0.56, 95% CI, 0.29–1.10, p = 0.09, respectively).InterpretationIn this PS matching analysis, EVT alone seemed to lead to similar neurological recovery than IVT + EVT, with comparable safety profile. However, given our sample size and the observational nature of this study, further studies are needed to confirm these findings. ANN NEUROL 2023;94:596–604
Unraveling the Oxidation Behaviors of MXenes in Aqueous Systems by Active‐Learning‐Potential Molecular‐Dynamics Simulation
Authors: Hou Pengfei , Tian Yumiao , Xie Yu , Du Fei , Chen Gang , Vojvodic Aleksandra , Wu Jianzhong , Meng Xing 
Published: June 2023

AbstractMXenes are 2D materials with great potential in various applications. However, the degradation of MXenes in humid environments has become a main obstacle in their practical use. Here we combine deep neural networks and an active learning scheme to develop a neural network potential (NNP) for aqueous MXene systems with ab initio precision but low cost. The oxidation behaviors of super large aqueous MXene systems are investigated systematically at nanosecond timescales for the first time. The oxidation process of MXenes is clearly displayed at the atomic level. Free protons and oxides greatly inhibit subsequent oxidation reactions, leading to the degree of oxidation of MXenes to exponentially decay with time, which is consistent with the oxidation rate of MXenes measured experimentally. Importantly, this computational study represents the first exploration of the kinetic process of oxidation of super‐sized aqueous MXene systems. It opens a promising avenue for the future development of effective protection strategies aimed at controlling the stability of MXenes.
Reprocessible Triketoenamine‐Based Vitrimers with Closed‐Loop Recyclability
Authors: Hu Zeyou , Hu Fan , Deng Lifeng , Yang Yumin , Xie Qiujian , Gao Zhu , Pan Chunyue , Jin Yinghua , Tang Juntao , Yu Guipeng , Zhang Wei 
Published: June 2023

AbstractDevelopment of thermosets that can be repeatedly recycled via both chemical route (closed‐loop) and thermo‐mechanical process is attractive and remains an imperative task. In this work, we reported a triketoenamine based dynamic covalent network derived from 2,4,6‐triformylphloroglucinol and secondary amines. The resulting triketoenamine based network does not have intramolecular hydrogen bonds, thus reducing its π‐electron delocalization, lowering the stability of the tautomer structure, and enabling its dynamic feature. By virtue of the highly reversible bond exchange, this novel dynamic covalent bond enables the easy construction of highly crosslinked and chemically reprocessable networks from commercially available monomers. The as‐made polymer monoliths exhibit high mechanical properties (tensile strength of 79.4 MPa and Young's modulus of 571.4 MPa) and can undergo a monomer‐network‐monomer (yields up to 90 %) recycling mediated by an aqueous solution, with the new‐generation polymer capable of restoring the material strength to its original state. In addition, owing to its dynamic nature, a catalyst‐free and low‐temperature reprogrammable covalent adaptable network (vitrimer) was achieved. The design concept reported herein can be applied to the development of other novel vitrimers with high repressibility and recyclability, and sheds light on future design of sustainable polymers with minimal environmental impact.
Discovery of dual inhibitors of pan‐RAF and VEGFR2
Authors: Park Eun Sun , Choi Jihye , Hong Sung Pyo , Kwon Ho‐Seok , Kim Jinho , Ahn Soon Kil 
Published: June 2023

AbstractColorectal cancer is among the most common and lethal malignancies globally, with K‐Ras mutations found in about 45% of colorectal cancer patients. Early‐stage BRAF‐specific inhibitors have been developed to prevent aberrant activation of RAS/RAF/MEK/ERK signaling caused by K‐Ras mutation, however, these BRAF‐specific inhibitors lead to RAF dimer formation and paradoxical CRAF activation. Consequently, there is a need to develop pan‐RAF inhibitors. In addition, it was reported that the inhibition of vascular endothelial growth factor receptor 2 (VEGFR2) is crucial for the treatment of colorectal cancer. In this study, we designed and synthesized 94 N‐(phenyl)‐3‐(9H‐purin‐6‐yl)pyridine‐2‐amine derivatives, and discovered that N‐(5‐(3‐(9H‐purin‐6‐yl)pyridin‐2‐ylamino)‐2‐fluorophenyl)‐3‐(trifluoromethyl)benzamide (15h), 3‐(2‐cyanopropan‐2‐yl)benzamide derivative 16h, and 3,5‐bis(trifluoromethyl) benzamide derivative 17ab are the most potent dual inhibitors against LS513 (GI50 = 0.08, 0.2, and 0.3 μM, respectively) and VEGFR2 (IC50 = 0.01, 0.004, and 0.01 μM, respectively). These compounds are excellent preclinical candidates for the treatment of K‐Ras mutated colorectal cancer.
Systemic management and periodontal treatment of HIV‐necrotizing periodontitis: A case report
Authors: Golob Deeb Janina , Elnakka Lina , Deeb George R 
Published: June 2023

AbstractBackgroundNecrotizing periodontitis (NP) is a rare form of periodontal disease. It can manifest in immunocompromised patients and present as painful and rapidly progressing destruction with necrotic and ulcerated periodontal tissues. This case report describes a rare case of severe NP in human immunodeficiency virus (HIV)‐positive patient including medical management and periodontal treatment.MethodsA 28‐year‐old male presented to the periodontal clinic with chief complaint of severe oral pain leading to loss of chewing ability, spontaneous gingival bleeding, generalized gingival recession, tooth mobility, and dentinal hypersensitivity. Clinical and radiographic examination revealed generalized tissue necrosis with severe periodontal destruction, extensive bleeding, spontaneous suppuration, and heavy biofilm.ResultsMedical history was positive for perinatal HIV infection, which was treated and patient was asymptomatic until he discontinued antiviral medications nine years ago. Following initial examination, patient was referred to the Infectious disease clinic and multidisciplinary management was initiated with comprehensive management of primary disease including systemic antiviral, antibiotic, and antifungal therapy to establish immunocompetence compatible with providing mechanical nonsurgical periodontal treatment.ConclusionsThis case report highlights a severe and generalized form of NP in an HIV patient due to the cessation of antiviral therapy. Favorable course of interdisciplinary medical and periodontal therapy resulted in significant improvement in patient's systemic, oral, and periodontal health.
Green Synthesis of Genistein‐Fortified Zinc Ferrite Nanoparticles as a Potent Hepatic Cancer Inhibitor: Validation through Experimental and Computational Studies
Authors: Otuechere Chiagoziem A. , Neupane Netra P. , Adewuyi Adewale , Pathak Prateek , Novak Jurica , Grishina Maria , Khalilullah Habibullah , Jaremko Mariusz , Verma Amita 
Published: June 2023

AbstractIn hepatic cancer, precancerous nodules account for damage and inflammation in liver cells. Studies have proved that phyto‐compounds based on biosynthetic metallic nanoparticles display superior action against hepatic tumors. This study targeted the synthesis of genistein‐fortified zinc ferrite nanoparticles (GENP) trailed by anticancer activity assessment against diethylnitrosamine and N‐acetyl‐2‐aminofluorene induced hepatic cancer. The process of nucleation was confirmed by UV/VIS spectrophotometry, X‐ray beam diffraction, field‐emission scanning electron microscopy, and FT‐IR. An in vitro antioxidant assay illustrated that the leaves of Pterocarpus mildbraedii have strong tendency as a reductant and, in the nanoformulation synthesis, as a natural capping agent. A MTT assay confirmed that GENP have a strong selective cytotoxic potential against HepG2 cancer cells. In silico studies of genistein exemplified the binding tendency towards human matrix metalloproteinase comparative to the standard drug marimastat. An in vivo anticancer evaluation showed that GENP effectively inhibit the growth of hepatic cancer by interfering with hepatic and non‐hepatic biochemical markers.
Oral chemical ulceration due to iatrogenic hydraulic oil leakage from the dental unit of a surgical handpiece: A case report
Authors: AL‐Hamad Khalid A. 
Published: June 2023

Key Clinical MessageOral chemical ulceration is a rare condition. The causes differ from misuse of dental material by dentists and over‐the‐counter drugs (OTC) to the herbal ingredients in our foods. Detailed patient history helps to explore the diagnosis and further management of such a lesion, which extend from no intervention in mild cases to surgical intervention in severe cases. This report represents a case of chemical ulceration of the mouth caused by hydraulic fluid oil leakage inside a dental chair in a 24‐year‐old female, leading to the patient developing multiple painful oral ulceration after surgical extraction. The purpose of the report is to increase awareness among health practitioners of unusual causes that could happen during dental interventions.
The progression of traumatic Stanford type A acute aortic dissection
Authors: Nishiori Hironobu , Fujita Hisanori , Yamaguchi Seiichi 
Published: June 2023

Key Clinical MessageCardiopulmonary bypass for trauma patients carries the risk of bleeding from injured organs, while traumatic aortic dissection can progress rapidly. It is sometimes difficult to determine the optimal time for aortic repair in trauma patients.AbstractAn 85‐year‐old woman was diagnosed with traumatic ascending aortic dissection, right clavicle and left first rib fracture, and abdominal contusions after a vehicle accident. After admission, the aortic dissection progressed, and emergent surgery was performed. Although the risk of hemorrhagic complications needs to be evaluated, prompt aortic repair is required.
Primary scrotal lipoma posing a diagnostic quandary: Experience from northern Tanzania, a case report
Authors: Mbwambo Orgeness Jasper , Pallangyo Angela , Mbwambo Jasper Saidi , Bright Frank , Mteta Alfred K. , Bogdanowicz Jacques , Ngowi Bartholomeo Nicholaus 
Published: June 2023

AbstractPrimary scrotal lipoma is a rare urological diagnosis. It is usually diagnosed incidentally as most of time initial diagnosis may be confused with other common etiology of scrotal masses. A rare case of scrotal lipoma with initial misdiagnosis of hydrocele at primary health facility is presented in this article.
Harlequin syndrome during peripheral cardiopulmonary bypass in a patient with an obstructing tracheal schwannoma: A case report
Authors: Karam Cynthia , Abou Nafeh Nancy , Aouad Marie T. , Siddik‐Sayyid Sahar , Kaddoum Roland , Zeeni Carine , Anka Sandra , Shaya Bashir , Khalili Amro 
Published: June 2023

AbstractSurgical resection of obstructive tracheal tumors can be challenging to cardiothoracic surgeons and anesthesiologists. It is often difficult in these cases to maintain oxygenation by face mask ventilation during induction of general anesthesia. Also, the extent and location of these tracheal tumors can preclude conventional induction of general anesthesia and subsequent successful endotracheal intubation. Peripheral cardiopulmonary bypass (CPB) under local anesthesia and mild intravenous sedation may be safe to support the patient until securing a definitive airway. We describe a case of a 19‐year‐old female with a tracheal schwannoma, who developed differential hypoxemia (Harlequin, or North–South, syndrome) after institution of awake peripheral femorofemoral venoarterial (VA) partial CBP.
Plexiform neurofibromatosis of the bladder leading to cystectomy: A rare complication of von Recklinghausen disease
Authors: Paymannejad Saina , Rafei Dehkordi Pardis , Kazemi Reza 
Published: June 2023

Key Clinical MessageWe report a 20‐year‐old man with neurofibromatosis type 1 presenting with frequent episodes of suprapubic pain. The episodes started 6 months ago, occurred 1 h a day, and were not related to urination. A prostate‐sparing cystectomy with orthotopic diversion was performed. Histopathological assessment of the specimen confirmed bladder plexiform neurofibromatosis.
Upper extremity deep vein thrombosis following BBIBP‐CorV COVID‐19 vaccine (Sinopharm vaccine): A case report
Authors: Riazi Ali , Faghih Dinevari Masood , Abbasian Samaneh , Jabbaripour Sarmadian Amirreza 
Published: June 2023

Key Clinical MessageIn patients with acute symptoms such as pain, swelling, and erythema of the upper extremities shortly after receiving COVID‐19 vaccines, even inactivated virus vaccines, these symptoms may indicate thrombosis, which may be due to the vaccination.AbstractBBIBP‐CorV COVID‐19 vaccine (Sinopharm vaccine) is an inactivated whole virus vaccine to control the COVID‐19 pandemic. Studies concluded that inactivated COVID‐19 vaccines do not increase the risk of thrombosis. This report presents a 23‐year‐old man with the chief complaint of severe pain, swelling, and erythema of the right upper extremity following his second dose of the Sinopharm vaccine. Duplex ultrasound of the right upper extremity revealed upper extremity deep vein thrombosis, and treatment started with oral anticoagulation. It is probably the first upper extremity deep vein thrombosis case following inactivated COVID‐19 vaccines.
Imaging of a case of atrioventricular septal defect: The added value of using the third dimension in echocardiography
Authors: Abdelnabi Mahmoud , Almaghraby Abdallah , Abdelgawad Hoda 
Published: June 2023

Key Clinical MessageThe role of 3D echocardiography has been increasing in the management of patients with congenital heart disease (CHD), particularly in pre‐surgical planning, catheter‐guided interventions, and functional assessment of the heart.
Successful penile reimplantation after 8 h post penile self‐mutilation: A case report
Authors: Salem Mohammed Saleh E. Khalifa , Alherek Abdul , Muangalayi Francis , Tshiala Alain Kabongo , Mukendi Alain Mwamba 
Published: June 2023

Key Clinical MessagePenile self‐mutilation may result from a suicidal attempt during a major depression crisis. The management of this urological emergency should be multidisciplinary. A macroscopic penile reimplantation performed meticulously by a urological surgeon may yield an excellent cosmetic and functional outcome.AbstractPenile self‐mutilation is an infrequent form of self‐harming behavior seen primarily in patients with schizophrenia spectrum disorders and rarely reported in those with major depressive disorders.We herewith present a major depression related case of penile self‐mutilation successfully managed by macroscopic penile reimplantation performed 8 h after the incident.
Addressable DNA Information Processing System with a Fluorescent Readout for Rewritable Memory
Authors: Xi Zirui , Yang Mengyao , Hu Yuqiang , Wu Tongbo 
Published: June 2023

Comprehensive SummaryDNA‐based nanostructure allows the construction of molecular devices useful in biological computing and information processing. Herein, an addressable and editable DNA information processing system established on a fluorescence intensity signal detection platform to save and encrypt information is proposed. The system operates by encoding information into distinct and changeable units of the trigger strands decoding by fluorescence intensity signal detection. Through toehold‐mediated strand displacement reactions, the trigger strand can be precisely added to and removed from the memorizer and reporter to implement the function of editing, encrypting, and decrypting. Our strategy is simple to implement, requiring only two mixing steps at room temperature for each operation and fluorescence intensity signal detection to read the data. And the system can realize accurate retrieval of specific individual information, eliminating all unnecessary redundant readouts. Because of its point‐to‐point accurate readout and programmability, the system is expected to become a powerful tool for the future development of information storage and sensing of biological molecules.
Rhodium(III)‐Catalyzed Atroposelective C—H Indolylization of 1‐Aryl Isoquinolines with 3‐Indolylphenyliodonium Salts†
Authors: Zheng Dong‐Song , Zheng Jun , Wang Qiang , Gu Qing , You Shu‐Li 
Published: June 2023

Comprehensive SummaryRhodium(III)‐catalyzed enantioselective C—H indolylization of isoquinolines was developed. The C—H coupling reactions between 1‐aryl isoquinoline derivatives and 3‐indolylphenyliodonium salts proceeded smoothly in the presence of a modified chiral cyclopentadienyl‐Rh(III) complex, affording a series of axially chiral indolylated biaryl products in excellent yields and enantioselectivity (up to 98% yield and 95% ee).
Hemimegalencephaly and intractable focal seizures related to NPRL3 mutation with variable familial expressivity treated with anatomic hemispherectomy
Authors: Carozza Richard B. , Naftel Robert P. , Sarma Asha , Carter Emma G. 
Published: June 2023

AbstractIntroductionHemimegalencephaly is a syndrome of dysplastic cortical formation, with hamartomatous overgrowth of a cerebral hemisphere, classically associated with intractable focal epilepsy, hemiparesis, and hemianopia. While often cryptogenic, associations with various proliferative syndromes have been implicated, such as in our patients.Patient DescriptionWe present a newborn with intractable focal epilepsy due to hemimegalencephaly caused by an inherited mutation in nitrogen permease regulator‐like 3 (NPRL3). He underwent anatomic hemispherectomy. His phenotype was more severe than that of other family member, which is consistent with recent studies suggesting that NPRL3 and other genes implicated in familial focal epilepsy with variable foci (FFEVF) produce a phenotypic range.ConclusionsHemimegalencephaly can produce intractable focal epilepsy and has been associated with various genetic causes, including NPRL3 mutations. We describe the fifth patient with hemimegalencephaly secondary to NPRL3 and the only one to undergo anatomic hemispherectomy. Given the small number of documented patients, more research is needed to elucidate the role of interventions such as sirolimus and palliative surgical procedures such as hemispherectomy.
A novel two‐staged network for skin disease detection using atrous residual convolutional networks
Authors: Ramamurthy Karthik , Muthuswamy Anirudh , Mathimariappan Nagharjun , Kathiresan Gugan S. 
Published: June 2023

SummaryThe preferred modality for the identification of skin disease has predominantly been dermoscopy. Skin lesion identification is the primary diagnostic basis for the dermatologist to evaluate the severity and impact of the disease. Current diagnostic procedures for the identification of skin lesions may be subjected to misdiagnosis among observers. Also, these procedures are conventionally labour‐intensive and prone to delays in treatment. Deep learning has proven to be beneficial for automated computer‐aided diagnosis in the medical field. This research presents a two‐stage approach involving segmentation and classification architectures for the effective detection of skin disease. The proposed approach aims to combine the architectural benefits of residual learning with the contextual retention of atrous convolutions. The classification is performed on seven different classes of skin lesions namely, melanoma (MEL), melanocytic nevus (NV), basal cell carcinoma (BCC), actinic keratosis/Bowen's disease (AKIEC), benign keratosis (BKL), dermatofibroma (DF), and vascular lesion (VASC). To the best of our knowledge, this is the first research that reports the impact of a two‐staged detection network using atrous residual convolutions for these seven classes. Experimental observations indicate that the proposed model is characteristically balanced in terms of inter‐class performance, with precise segmentation. The proposed network was trained with the HAM10000 dataset and reported a classification accuracy and precision of 89.27% and 89.06%, respectively.
Genetic diversity of North American popcorn germplasm and the effect of population structure on nicosulfuron response
Authors: Sullivan Madsen , Williams Martin M. , Studer Anthony J. 
Published: June 2023

AbstractPopcorn (Zea mays) is an important crop in the United States; however, genetic analyses of popcorn are limited and tend to utilize relatively few markers that cannot capture the total genomic variation. To improve the genomic resources in popcorn, a panel of 320 popcorn accessions was evaluated using 308,811 single nucleotide polymorphisms (SNPs) generated using a genotyping‐by‐sequencing approach. Using this genomic data, several model‐based clustering analyses identified two major groups. The first comprised North American Yellow Pearl Popcorns and accessions of the Chilean Curagua landrace, separated into three subgroups. The second, the Pointed and Latin American Popcorns, included all remaining North American, Latin American, and global accessions. These groups exhibited differences in population structure and genetic diversity. The North American Yellow Pearl Popcorns contain limited genetic diversity compared to the Pointed and Latin American Popcorns. Additionally, phenotypic differences between the two groups were observed in kernel color and nicosulfuron sensitivity. A filtered set of SNPs was curated and used for genome‐wide association studies and popcorn‐specific candidate genes for nicosulfuron tolerance were identified. The genomic characterization described here can be used by breeding programs to accelerate the rate of genetic gain and incorporate genetic diversity into elite popcorn germplasm.