bluuebunny/crossref_metadata_2025_split huggingface dataset:
The deserving or undeserving rich? New survey evidence on multimillionaire households in Europe
Authors: Korom Philipp 
Published: December 2022

AbstractThis article addresses two questions. First, when do people consider the rich to be deserving? A literature survey reveals that it is first and foremost the origin of great wealth that determine public attitudes towards the rich. Rich people “deserve” to be rich if their wealth is perceived as having resulted from competence and hard work rather than from inheritance. Second, who are the rich? Drawing on data from the second wave of the European Household Finance and Consumption Survey (HFCS), it is found that multimillionaire households benefit disproportionately from wealth transfers. Large gifts and bequests alone, however, are not good predictors of rich household status. It is rather the highly educated top heir running a (family) business that best represents the rich in Europe. Such entrepreneurs who benefit from earned and unearned financial resources neither fully correspond to nor contradict the existing public beliefs in the “deservingness” of the rich. It is argued that, while still underresearched, it is the “hybrid rich” that dominate in the twenty-first-century capitalism that is marked by historically high levels of wealth inequality alongside inefficiencies in tax systems.
Machine learning can aid in prediction of IDH mutation from H&E-stained histology slides in infiltrating gliomas
Authors: Liechty Benjamin , Xu Zhuoran , Zhang Zhilu , Slocum Cheyanne , Bahadir Cagla D. , Sabuncu Mert R. , Pisapia David J. 
Published: December 2022

AbstractWhile Machine Learning (ML) models have been increasingly applied to a range of histopathology tasks, there has been little emphasis on characterizing these models and contrasting them with human experts. We present a detailed empirical analysis comparing expert neuropathologists and ML models at predicting IDH mutation status in H&E-stained histology slides of infiltrating gliomas, both independently and synergistically. We find that errors made by neuropathologists and ML models trained using the TCGA dataset are distinct, representing modest agreement between predictions (human-vs.-human κ = 0.656; human-vs.-ML model κ = 0.598). While no ML model surpassed human performance on an independent institutional test dataset (human AUC = 0.901, max ML AUC = 0.881), a hybrid model aggregating human and ML predictions demonstrates predictive performance comparable to the consensus of two expert neuropathologists (hybrid classifier AUC = 0.921 vs. two-neuropathologist consensus AUC = 0.920). We also show that models trained at different levels of magnification exhibit different types of errors, supporting the value of aggregation across spatial scales in the ML approach. Finally, we present a detailed interpretation of our multi-scale ML ensemble model which reveals that predictions are driven by human-identifiable features at the patch-level.
Demonstrating the utility of sugar-phosphate phosphatases in coupled enzyme assays: galactose-1-phosphate uridylyltransferase as proof-of-concept
Authors: Thirugnanasambantham Pankajavalli , Bashian Eleanor , Zaleski Rosemary , Gopalan Venkat 
Published: December 2022

AbstractDuring our biochemical characterization of select bacterial phosphatases belonging to the haloacid dehalogenase superfamily of hydrolases, we discovered a strong bias of Salmonella YidA for glucose-1-phosphate (Glc-1-P) over galactose-1-phosphate (Gal-1-P). We sought to exploit this ability of YidA to discriminate these two sugar-phosphate epimers in a simple coupled assay that could be a substitute for current cumbersome alternatives. To this end, we focused on Gal-1-P uridylyltransferase (GalT) that is defective in individuals with classical galactosemia, an inborn disorder. GalT catalyzes the conversion of Gal-1-P and UDP-glucose to Glc-1-P and UDP-galactose. When recombinant YidA was coupled to GalT, the final orthophosphate product (generated from selective hydrolysis of Glc-1-P by YidA) could be easily measured using the inexpensive malachite green reagent. When this new YidA-based colorimetric assay was benchmarked using a recombinant Duarte GalT variant, it yielded kcat/Km values that are ~2.5-fold higher than the standard coupled assay that employs phosphoglucomutase and glucose-6-phosphate dehydrogenase. Although the simpler design of our new GalT coupled assay might find appeal in diagnostics, a testable expectation, we spotlight the GalT example to showcase the untapped potential of sugar-phosphate phosphatases with distinctive substrate-recognition properties for measuring the activity of various metabolic enzymes (e.g. trehalose-6-phosphate synthase, N-acetyl-glucosamine-6-phosphate deacetylase, phosphofructokinase).
A bibliometric analysis and visualization of research trends on surgical hip dislocation
Authors: Peng Peng , Wei Tengfei , Fang Weihua , Xiao Fangjun , He Xiaoming , He Wei , Wei Qiushi , He Mincong 
Published: December 2022

ABSTRACT
Surgical hip dislocation (SHD) is a powerful and safe approach used to address pathologic lesions around the hip joint, and therefore, many studies have been conducted in this field. However, no bibliometric studies regarding the global research trend concerning SHD have been studied yet. This study aims to determine the research status in the field of SHD research between 2001 and 2021. The publications related to SHD from 2001 to 2021 were retrieved from the Web of Science Core Collection. Three bibliometric tools were used for this study. The main analyses include publication counts, contributions of countries, institutions, authors, journals and funding agencies, as well as analyses on clustering of references and keywords. In total, 498 articles were identified. The annual publication counts of SHD showed an ascending tendency as a whole. The United States has the most prominent contributions, with the most number of publications and the highest value of H-index. The University of Bern was the organization that produced the most literature. Professors Ganz R, Siebenrock KA, Tannast M, Steppacher SD and Leunig M were the core authors in this field. The most productive journal was Clinical Orthopaedics and Related Research. Burst keyword detection suggested that the following research directions, including ‘surgical hip dislocation’, ‘outcome’, ‘fixation’ and ‘pain’, are considered the research hotspots and deserve more attention. In conclusion, this is the first bibliometric analysis that provides a comprehensive overview of SHD research, which may assist investigators in exploring new directions for this technique.
A novel strand-specific RNA-sequencing protocol using dU-adaptor-assembled Tn5
Authors: Tao Xiaoyuan , Feng Shouli , Li Sujuan , Chen Guang , Wang Jian , Xu Lizhi , Fu Xujun , Yu Jing , Xu Shengchun 
Published: December 2022

AbstractStrand-specific RNA-seq is a powerful tool for the discovery of novel transcripts, annotation of genomes, and profiling of gene expression levels. Tn5 transposase has been successfully applied in massive-scale sequencing projects; in particular, Tn5 adaptor modification is used in epigenetics, genomic structure, and chromatin visualization. We developed a novel dU-adaptor-assembled Tn5-mediated strand-specific RNA-sequencing protocol and compared this method with the leading dUTP method in terms of experimental procedure and multiple quality metrics of the generated libraries. The results showed that the dU-Tn5 method is easy to operate and generates a strand-specific RNA-seq library of comparable quality considering library complexity, strand-specificity, evenness, and continuity of annotated transcript coverage. We also evaluated the performance of the dU-Tn5 method in identifying nitrogen-responsive protein-coding genes and long non-coding RNAs in soybean roots. The results indicated that ~62–70% of differentially expressed genes detected from conventional libraries were also detected in dU-Tn5 libraries, indicating good agreement of our method with the current standard; moreover, their fold-changes were highly correlated (R&gt;0.9). Thus, our method provides a promising ‘do-it-yourself’ stranded RNA-seq procedure for gene expression profiling.
Iatrogenic immunodeficiency-associated lymphoproliferative disorders of the central nervous system: a treatment paradox
Authors: Tadipatri Ramya , Ekhator Chukwuyem , Narayan Ram , Azadi Amir , Yuen Kevin C J , Grewal Jai , Fonkem Ekokobe 
Published: December 2022

AbstractBackgroundPrimary central nervous system lymphomas (PCNSLs) have historically had dismal survival rates until the advent of high-dose methotrexate (HD-MTX) based chemotherapy regimens. With increasing prevalence of autoimmune disease and development of new immunosuppressants, a genetically distinct entity known as iatrogenic immunodeficiency-associated lymphoproliferative disorder (LPD) has emerged. Many of these cases arise following methotrexate use, challenging feasibility of standard HD-MTX regimens. The aim of this study was to further characterize this disorder and determine the optimal management strategy.MethodsWe describe a case of a 76-year-old female with iatrogenic immunodeficiency-associated PCNSL successfully treated with surgical resection followed by an antiviral and rituximab based regimen. We then performed a systematic literature review and identified 58 cases of non-transplant iatrogenic immunodeficiency-associated LPD involving the CNS. We used a linear probability statistical model to determine correlations with outcome.ResultsNatalizumab was associated with EBV negative tumors (P = .023), and EBV positive tumors were associated with improved outcomes (P = .016). Surgical resection was associated with improved outcomes (P = .032), although limited by potential confounding effect. Antiviral treatment (P = .095), rituximab (P = .111), and stem cell transplant (SCT) (P = .198) showed a trend toward improved outcomes. The remaining treatments including methotrexate showed no improvement.ConclusionWe propose that surgical resection, rituximab, and antiviral treatment may be considered as an alternative to standard HD-MTX based regimens when managing iatrogenic immunodeficiency-associated LPD of the CNS. Further study through prospective cohort studies or randomized clinical trials is warranted.
“What do we want and how do we get there”: A comparative content analysis of First Nations Comprehensive Community Plans in British Columbia
Authors: Kobzik Juraj , Krawchenko Tamara 
Published: December 2022

AbstractFirst Nations are important regional development actors, and yet their development ambitions and goals have often been ignored or poorly understood by settler governments. Since 2004, the Canadian federal government has supported First Nations governments and Tribal Councils to develop Comprehensive Community Plans (CCPs)—community planning documents that are meant to set priorities and guide development in the medium to long term. This study employs a quantitative content analysis of all publicly available CCPs and related strategic planning documents in British Columbia in order to understand development priorities and in doing so, reveals a mismatch between the interests of First Nations and settler governments.
A deep learning model for prognosis prediction after intracranial hemorrhage
Authors: Pérez del Barrio Amaia , Esteve Domínguez Anna Salut , Menéndez Fernández‐Miranda Pablo , Sanz Bellón Pablo , Rodríguez González David , Lloret Iglesias Lara , Marqués Fraguela Enrique , González Mandly Andrés A. , Vega José A. 
Published: December 2022

AbstractBackground and PurposeIntracranial hemorrhage (ICH) is a common life‐threatening condition that must be rapidly diagnosed and treated. However, there is still a lack of consensus regarding treatment, driven to some extent by prognostic uncertainty. While several prediction models for ICH detection have already been published, here we present a deep learning predictive model for ICH prognosis.MethodsWe included patients with ICH (n = 262), and we trained a custom model for the classification of patients into poor prognosis and good prognosis, using a hybrid input consisting of brain CT images and other clinical variables. We compared it with two other models, one trained with images only (I‐model) and the other with tabular data only (D‐model).ResultsOur hybrid model achieved an area under the receiver operating characteristic curve (AUC) of .924 (95% confidence interval [CI]: .831‐.986), and an accuracy of .861 (95% CI: .760‐.960). The I‐ and D‐models achieved an AUC of .763 (95% CI: .622‐.902) and .746 (95% CI: .598‐.876), respectively.ConclusionsThe proposed hybrid model was able to accurately classify patients into good and poor prognosis. To the best of our knowledge, this is the first ICH prognosis prediction deep learning model. We concluded that deep learning can be applied for prognosis prediction in ICH that could have a great impact on clinical decision‐making. Further, hybrid inputs could be a promising technique for deep learning in medical imaging.
Doxycycline‐doped collagen membranes accelerate in vitro osteoblast proliferation and differentiation
Authors: Toledano‐Osorio Manuel , de Luna‐Bertos Elvira , Toledano Manuel , Manzano‐Moreno Francisco Javier , García‐Recio Enrique , Ruiz Concepción , Osorio Raquel , Sanz Mariano 
Published: December 2022

AbstractObjectiveThe aim of the study was to evaluate the effect of doxycycline‐ and dexamethasone‐doped collagen membranes on the proliferation and differentiation of osteoblasts.BackgroundCollagen barrier membranes are frequently used to promote bone regeneration and to boost this biological activity their functionalization with antibacterial and immunomodulatory substances has been suggested.MethodsThe design included commercially available collagen membranes doped with doxycycline (Dox‐Col‐M) or dexamethasone (Dex‐Col‐M), as well as undoped membranes (Col‐M) as controls, which were placed in contact with cultured MG63 osteoblast‐like cells (ATCC). Cell proliferation was assessed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium (MTT) assay and differentiation by measuring the alkaline phosphatase (ALP) activity using spectrophotometry. Real‐time quantitative polymerase chain reaction was used to study the expression of the genes: Runx‐2, OSX, ALP, OSC, OPG, RANKL, Col‐I, BMP‐2, BMP‐7, TGF‐β1, VEGF, TGF‐βR1, TGF‐βR2, and TGF‐βR3. Scanning electron microscopy was used to study osteoblast morphology. Data were assessed using one‐way analysis of variance or Kruskal–Wallis tests, once their distribution normality was assessed by Kolmogorov–Smirnov tests (p > .05). Bonferroni for multiple comparisons were carried out (p < .05).ResultsOsteoblast proliferation was significantly enhanced in the functionalized membranes as follows: (Col‐M < Dex‐Col‐M < Dox‐Col‐M). ALP activity was significantly higher on cultured osteoblasts on Dox‐Col‐M. Runx‐2, OSX, ALP, OSC, BMP‐2, BMP‐7, TGF‐β1, VEGF, TGF‐βR1, TGF‐βR2, and TGF‐βR3 were overexpressed, and RANKL was down‐regulated in osteoblasts cultured on Dox‐Col‐M. The osteoblasts cultured in contact with the functionalized membranes demonstrated an elongated spindle‐shaped morphology.ConclusionThe functionalization of collagen membranes with Dox promoted an increase in the proliferation and differentiation of osteoblasts.
The effect of three different sets method used in resistance training on hypertrophy and maximal strength changes
Authors: Demirtaş Barbaros , Çetin Onat , Çakır Ergün , Beyleroğlu Malik 
Published: December 2022

Background and Study Aim. To compare the effects of three different sets method, which is frequently used in resistance training, on strength and hypertrophy values.
Materials and Methods. Thirty-three young male athletes with similar daily activities and nutrient intakes at the Fitlife fitness center in Sakarya were included in the study. Participants were randomly divided into three different groups as Modified German Volume Training (MGVT) (n=11, 21.5 ± 2.4 years), Super Set (SS) (n=11, 22.4 ± 2.9) and Giant Set (GS) (n=11, 23.0 ± 4.3 years). The study was started with a total of thirty-three people, but two participants in the Giant set group were excluded from the measurements because they left the study due to personal reasons. Strength, muscle thickness and cross-sectional area (CSA) measurements were made in the upper extremity muscles before and after the six-week training period.
Results. After six weeks of training, significant increases were observed in the cross-sectional area and thickness (p<0.05) of pectoralis major, deltoid, and latissimus dorsi muscle groups in all three groups, and in the strength parameter (p<0.05) in bench press, barbell row and shoulder press exercises. There was no difference in strength, muscle cross-sectional area and thickness parameters between the groups (p>0,05).
Conclusions. Modified German Volume Training (MGVT), Super Set (SS) and Giant Set (GS) methods reveal that there is no difference between the set methods in the 1 Repetition Maximum (1RM) strength and hypertrophy development of young male individuals who do not have a history of resistance exercise but have completed the adaptation period, and that there is an improvement in all set methods.
The State of Loneliness among Migrating Students: The Effect of Psychological Well-Being and Religiosity
Authors: Laksmidara Mahadewi , Nashori Fuad 
Published: December 2022

Being separated from their parents causes many migrating students to experience loneliness, not to mention their age range is prone to it. Therefore, this study aims to determine the effect of psychological well-being and religiosity on loneliness and isolation in migrating students using ex post facto quantitative research methods. Respondents to this study were active 213 migrating students in several universities in Yogyakarta Special Religion, Indonesia. Their ages ranged from 18 to 24 years old. The measuring instruments used were UCLA Loneliness version 3 (α 0.942), the Psychological Well-being Scale (α 0.776), and The Centrality of Religiosity Scale (α) 0.876). The data analysis technique used was multiple regression. The results indicated a significant negative effect of psychological well-being on loneliness and no significant negative impact of religiosity on loneliness in migrating students. Psychological well-being and religiosity contributed 58.2% to influencing the loneliness variable. The main conclusion this study is psychological well-being makes migrating students experience less loneliness when they are far away from their hometowns.
The Effect of a Training Package on Self-Efficacy and Mental Health of Female High School Students regarding the Healthy Human Theory
Authors: Asadi Anita , Aghaei Asghar 
Published: December 2022

Introduction: The aim of this study is to investigate the effect of educational package of healthy human theory on self-efficacy and mental health of female high school students in Fooladshahr.
Methods: The research method was quasi-experimental and included a pretest, posttest and a one-month follow-up. The statistical population included all the female high school students (1,200 students) in Fooladshahr in the academic year 2020-2021. Convenience sampling method was used ,and a secondary school in Fooladshahr was selected. Then, mental health screening and self-efficacy questionnaires were distributed among the students. In the second stage, 30 students were selected from those who had lower mental health and self-efficacy and were willing to participate in the study. They were randomly assigned to experimental (n = 15) and control (n = 15) groups. The experimental group received thirteen sessions of a revised version of training based on the healthy human theory (Aghaei, Asadi, 2021). The control group remained on the waiting list. Data collection tools in the pretest, posttest and follow-up stages included the Morris Children and Adolescents Self-Efficacy Questionnaire (2001) and the Keys Mental Health Scale (2002). In order analyze data, the analysis of variance with repeated measures was used.
Results: The results showed that the training package regarding the healthy human theory had a significant effect on improving self-efficacy and mental health of students in the posttest stage (p <0.001). The effect continued to the follow-up stage (p <0.001).
Conclusion: According to the findings of this study, it can be said that the training package regarding the healthy human theory has been a suitable method for improving self-efficacy and mental health of female students from senior high school.
«Authority» as a factor in evaluating the activity of Odesa city mayors within the period from the second half of the 19th century to the beginning of the 20th century by contemporaries
Authors: Herasymenko Viktoriia 
Published: December 2022

The article examines the importance of one of the factors in evaluating the activity of city mayors as authority (position, status, etc.). In the second half of the 19th – at the beginning of the 20th century. the self-government of Odesa was headed by Semen Vorontsov, Mykola Novoselskyi, Grigory Marazli (Grigorios Maraslis), Valerian Ligin, Petro Kryzhanovskyi and Pavlo Zelenyi. On the basis of the collected sources (notes from the press and memories of contemporaries) and due to the activity and position of the city mayor the establishment of the authority of the above-mentioned personalities was analyzed.
The authority is based on professionalism, knowledge, moral principles, social status, experience or myths. Due to authority, human can exercise control over people's actions. There are also different authorities of a person's quality (scientific, business, moral, religious, etc.) and his status (respect for the position). The effectiveness of government largely depends on its authority.
The main sources for determining the assessment of the authority factor of the Odesa city mayors of 1863-1905 are the press (the newspapers «Odesa Herald», «Odesa News», «Odesa Leaf», etc.), diaries and memories of contemporaries (E. Andreevskii, K. Skalkovskyi, M. Lents, etc.).
As a result of studying a number of personalities, it became clear that the group of Odesa mayors was diverse. Taking the position of mayor during the elected term, S. Vorontsov, M. Novoselskyi, G. Marazli, V. Ligin, P. Kryzhanovskyi and P. Zelenyі acquired status authority (respect for the position of the head of the city self-government). However, not all of the above-mentioned persons could use it qualitatively.