bluuebunny/crossref_metadata_2025_split huggingface dataset:
DoE Enabled Development and In-Vitro Optimization of Curcumin-tagged Cilostazol Solid Nano Dispersion
Authors: Rawat Aruna , Jhawat Vikas , Dutt Rohit 
Published: July 2023

Background:
Diabetes is a prevailing disease worldwide and its complications are also hazardous including nephropathy. Drug available to treat Diabetic Nephropathy (DN) faces bioavailability issues related to solubility and absorption of drugs. Cilostazol (CLT) is a BCS class II drug that is poorly water-soluble which affects its therapeutic efficacy. CLT reduces reactive oxy-gen species (ROS) increased in DN. Curcumin (Cur) is also hydrophobic but Cur has many therapeutic efficacies like anti-inflammatory and antioxidant properties that help for the treatment of DN.

Objective:
The objective of the current study was to develop and optimize the Cilostazol Solid Dis-persion Nanoparticle (SDN) to improve the bioavailability of the drug by tagging it with Cur by us-ing PVP VA S 630 as polymer and Poloxamer 407 as surfactant.

Method:
Different formulations were developed using the emulsion solvent evaporation method, PVP VA S 630 as the hydrophilic polymer, and Poloxamer 407 as a surfactant. Two-factor, three-level Box-Behnken Design (BBD) was used for statistical analysis of the selected process variable's main effect and interactive effect on the response. Curcumin tagging was also done for the entire batches. Nanoparticles were characterized by FT-IR spectroscopy, DSC, Particle size, Zeta poten-tial, Drug entrapment efficiency, Solubility, and % CDR studies.

Results:
Among the 17 different formulations (CLT1-CLT 17), with a solubility of 39.5 μg/ml, a % CDR of 99.55, a typical particle size of 219.67 nm with a PDI of 0.258, entrapment efficiency of 73.47%, and a -10.6 mV of Zeta potential, CLT-15 was optimized. To determine CLT and curcu-min, the simultaneous UV calibration method was created. Overall, the DSC study indicated the amorphous nature of the Nano Dispersion, which in turn means the successful entrapment of the CLT in the Nano Dispersion matrix. TEM images also confirmed the spherical nanoparticles. The optimized batch of drugs tagged with curcumin was compared with the plain drug Solid Dispersion Nanoparticles.

Conclusion:
Together with the molecules of curcumin, the solid nano dispersion of CLT was pro-duced, which will add to the benefits of the management of Diabetic Nephropathy. In the current study, we underline the importance of utilising both API and phytochemicals in the treatment of Di-abetic Nephropathy, and we anticipate further basic research or clinical trials to support innovative treatments. It is possible to use these matrix-forming polymers for active ingredients with poor sol-ubility, whether they are natural or synthetic. It has also been demonstrated that these carriers (PVP VA S 630 & Poloxamer) increase the dissolution rate (in-vitro).
SCADA Sistem Pengisian dan Pengepakan Kemasan Multigrain Rice Berisi 2-3 Macam Biji-bijian
Authors: Setiyani Theresia Prima Ari , Kristoforus Adrian , Maretyana Yashinta 
Published: July 2023

The process of packing food products manually raises many problems, including inefficiency, quality of hygiene, changing the composition according to market demand, and monitoring, that are difficult to do remotely in real-time. This research builds SCADA for filling and packing Multi-grain rice packages containing 2-3 kinds of grains.The composition of the grain be filled in the package through the HMI. The conveyor moves to carry the packing bags and stops at each grain container. The rotary vane feeder of the container will rotate so that the packaging bag will be filled with grains and then glued together. The position of the packaging bag is detected by 3 pairs of photosensors. The actuator control uses a Schneider M221 PLC via ethernet port. The communication system between the I/O devices and the PLC uses a cable, while the communication between the PLC and the HMI is via the internet network.The system is capable of filling the material according to the desired composition, sealing, and packing to the number of packages. HMI feeds composition input to the system, displays animations correctly, raises an alarm when the material in the tub is running low, and record production as a daily report.
Development of interactive e-LKPD based on creative thinking skills on the concept of environmental change
Authors: Ricky Ardiansah  , Zulfiani Z. 
Published: July 2023

Students' worksheets (Lembar Kerja Peserta Didik/LKPD) are needed as alternative teaching materials in learning. This study aims to produce electronic students' worksheets (e-LKPD) based on creative thinking skills on the concept of environmental change. In addition, this study also aims to determine the level of validity, readability, and practicality of the Interactive e-LKPD developed. The research method used is Developmental Research using the stages of Akker et al which consists of 3 stages, namely: Analysis, Design and Development, and Evaluation Phase. Validity test results obtained an average percentage value of 90.06% with a very valid category. The readability test results obtained an average percentage value of 94.91% with a very positive category. The results of the practical test by biology teachers and students obtained an average percentage of 100% and 81.22%, with both categories being very practical. Based on the test results that have been done, it can be concluded that the Interactive E-LKPD is very feasible to use in learning activities. Therefore, the existence of interactive E-LKPD as a source of alternative teaching materials to develop students creative thinking skills in biology learning is in line with the implementation of Kurikulum Merdeka (Freedom Curriculum).
Nilai Karakter Kepedulian Sosial Tokoh Mohammad Hatta
Authors: Fathoni Ahmad , Purnomo Budi , Indrayani Nelly 
Published: July 2023

Nilai karakter kepedulian sosial tokoh Mohammad Hatta. Di dalam penelitian ini terdapat 2 rumusan masalah yaitu bagaimana kepedulian sosial tokoh Mohammad Hatta, bagaimana nilai-nilai karakter kepedulian sosial Mohammad Hatta sebagai sumber belajar sejarah siswa di SMA. Tujuan bagaimana nilai-nilai karakter tokoh Mohammad Hatta dijadikan sebagai sumber belajar sejarah siswa di SMA. Penelitian ini merupakan penelitian kualitatif dengan jenis penelitian kualitatif dengan pendekatan studi pustaka. Sumber data dalam penelitian ini adalah sumber data sekunder dengan teknik analisis data berupa analisis induksi melalui tahapan pengumpulan data, reduksi data, display data dan pengambilan kesimpulan. Penelitian ini dilakukan di SMAN 11 Kota Jambi, Perpustakaan Universitas Jambi, Perpustakaan wilayah Provinsi Jambi..

Kata Kunci : Karakter, Kepedulian Sosial Mohammad Hatta
PELESTARIAN TRADISI DAN BUDAYA MASYARAKAT TRANSMIGRASI ETNIS JAWA PROPINSI JAMBI (KAJIAN HISTORIS DAN NILAI BUDAYA LOKAL KESENIAN JATILAN UNIT V SUNGAI BAHAR)
Authors: Wahyuni Anny , Nurismawati Dewi , Adi Saputra Muhammad 
Published: July 2023

Penelitian ini membahas tentang perkembangan kesenian Jatilan di Unit V Sungai Bahar Propinsi Jambi 1990-2020. Permasalahan yang di bahas mengenai keberadaan kesenian jatilan di Unit V sungai Bahar yang di tinjau dari sisi historis mulai dari sejarah kedatangan kesenian ini, perkembangannya, dinamika dan pergeseran yang terhadu, peran masyarakat transmigrasi dalam melestarikan dan mengembangkan kesenian ini serta dampak yang ditimbulkan akibat modernisasi dan perkembagan teknologi. Metode yang digunakan dalam penelitian ini adalah metode sejarah yang langkah-langkahnya terdiri dari Heuristik (pengumpulan sumber), kritik sumber, Interpretasi dan Historiografi. Kesenian jatilan adalah sebuah kesenian yang menyatukan antara unsur gerakan tari dengan unsur magis yang dimainkan dengan mengunakan properti berupa kuda tiruan yang dibuat dari anyaman bambu yang di kepang. Kesenian Jatilan yang terdapat di unit V Sungai Bahar Propinsi Jambi dibawa oleh masyarakat transmigrasi yang berasal dari pulau jawa. Kesenian ini sampai sekarang masih memiliki eksistensi walaupun mengalami berbagai perubahan. Kesenian Jatilan dikenal dengan unsur-unsur kesakralan dan nilai-nilai budaya yang melekat didalam setiap gerakannya, sehingga menjadikan kesenian ini unik dan harus dilestariakan. Kesenian Jatilan ini sangat di gemari hamper setiap acara besar kesenian ini dipakai sebagai sarana hiburan masyarakat. Dampak dari kesenian jatilan ini bagi kesenian lain dibuktikan dengan bergabungnya kesenian gedrug. Dampak sosial ekonomi kesenian jatilan ini menambah pendapatan anak-anak muda.
IMPLIKASI BUDAYA TERHADAP KETAKWAAN
Authors: Muslim Ibnu Fiqhan , Priyono Priyono , Ranam Sanudin 
Published: July 2023

Budaya dikaitkan dengan agama tentunya punya hubungan yang erat. Budaya akan kehilangan jika tidak dilandasi ajaran agama. Budaya hasil karya manusia yang bertentangan dengan pesan al-Quran, ada yang akan kehilangan unsur epistimologinya dan ontologinya. Apalagi jika kecenderungangnya menolak ajaran al-Qur’an. Oleh karena itu, akan terbukalah berbagai bentuk kemaksiatan yang mengancam timbulnya kehancuran moral dan ahlak masyarakat. Penelitian ini dilatarbelakangi adanya ancaman mengenai moral yang mulai memudar dan akhlak anak bangsa yang hari demi hari dirasakan semakin memprihatinkan. Penelitian ini digunakan metode ilmiah dengan kajian pustaka atau disebut juga studi pustaka. Dengan metode ini, penulis dapat meyelesaikan permasalahan penelitian yang akan diteliti. Penulis mempunyai tujuan untuk lebih mendalami tentang budaya keterkaitannya dengan tumbuh kembangnya ketakwaan seseorang, dengan mengacu kepada minhaj al-Qur’an. Jika kita mengamati pesan al-Quran, al-Qur’an meletakkan suatu dasar budaya dan tentunya kebudayaan manusia sesuai dengan seluruh potensi yang dimiliki mahkluk insani sejak diciptakannya. Hasil penelitian menunjukkan bahwa implikasi atau keterlibatan budaya untuk mencapai tujuan pendidikan agar anak didik memiliki ketaqwaan kepada Allah SWT sangatlah penting dan harus diperhatikan terus menerus secara berkesinambungan oleh pendidik dan masyarakat pendidikan dengan melihat situasi serta kebutuhan anak didik.
How Entrepreneurship Orientation Influences the Performance of New Product Development in the SME in Bantul?
Authors: Diantoro Aris Kusuno , Ikhsan Foster , Kusmantini Titik , Janah Anisa Wardatul 
Published: July 2023

The prosperity of a company depends heavily on the quality of its new product development. Small and medium-sized enterprises (SMEs) must regularly assess, update, and adapt their product line. It has been argued that entrepreneurial orientation is crucial to improving enterprise-level outcomes like company performance in today's competitive environment where product life cycles are getting shorter. Objectives: This study aims to examine entrepreneurial orientation’s impact on new product development performance with business model innovation serving as a moderating variable. Methodology: The quantitative method is used in this study. The population under study consists of SMEs in Bantul Regency. This research employs a method of sampling known as purposive sampling with certain criteria. Partial Least Square (PLS) Structural Equation Modeling is utilized for analysis (SEM). Finding: This research shows that an entrepreneurial Orientation significantly affects the development of business model innovation. Product development performance is significantly influenced by the degree of innovation introduced into the business model and by the degree to which the entrepreneurial is oriented. Conclusion: Business model innovation is a great system for SMEs to bring their entrepreneurial spirit to innovation and also to improve the latest product development.
Depressive Symptoms Longitudinally Mediate the Effect of Hyperglycemia on Memory Decline in Type 2 Diabetes
Authors: Zarina Kraal A. , Ellingrod Vicki L. , B. Zahodne Laura 
Published: July 2023

<p> </p>
<p><strong>OBJECTIVE:</strong> We sought to examine the mediating role of changes in depressive symptoms in the association between chronic hyperglycemia and longitudinal cognition in a sample of older adults with type 2 diabetes (T2D).</p>
<p><strong>RESEARCH DESIGN AND METHODS: </strong>We conducted a longitudinal mediation analysis using structural equation modeling of observational data collected over six years from 2155 participants with T2D (ages 51+) in the U.S.-wide Health and Retirement Study. T2D was defined using self-reported diagnosis, and HbA1c was assessed at study baseline. Self-reported depressive symptoms were assessed at two time points, four years apart. Episodic memory was measured using a list-learning test administered at three time points over six years. We adjusted for socio-demographics, chronic health comorbidities, medication adherence, study enrollment year, and prior years’ depressive symptoms and memory scores.</p>
<p><strong>RESULTS:</strong> At baseline, mean age was 69.4 ± 9.1, mean HbA1c was 7.2% ± 1.4%, 55.0% were women, 19.3% were non-Latinx Black, and 14.0% were Latinx. Higher baseline levels of HbA1c were associated with increases in depressive symptoms over four years, which in turn, were associated with lower memory two years later. Depressive symptoms accounted for 19% of the longitudinal effect of HbA1c on memory over the six-year period. Sensitivity analyses ruled out alternative directions of associations.</p>
<p><strong>CONCLUSIONS:</strong> Incident elevations in depressive symptoms mediated the longitudinal association between hyperglycemia and six-year episodic memory scores. For older adults with T2D, interventions to prevent HbA1c-related incident depressive symptoms may be beneficial in reducing the neurotoxic effects of chronic hyperglycemia on cognition.</p>
La cultura y el engagement organizacional: el caso de una institución de educación superior
Authors: Gómez-Romero José Gerardo Ignacio , Rojero Jiménez Roberto , Villarreal-Solís Francisco Martín 
Published: July 2023

La cultura organizacional ha determinado el comportamiento de los individuos en las empresas y ha forjado una personalidad colectiva que, según numerosos estudios, influye en la conducta y la productividad de los trabajadores. Por ello, las ciencias administrativas han puesto especial interés en su estudio con la finalidad de determinar su impacto en tópicos como el liderazgo, trabajo en equipo, cohesión social, entre otros. Por tanto, en la presente investigación —sustentada en un enfoque cuantitativo, con un alcance correlacional y un diseño no experimental transversal— se procura explicar la influencia de la cultura organizacional en el engagement de los trabajadores del Tecnológico Nacional de México, según los modelos de Cameron y Quinn (2006), y Salanova et al. (2000), respectivamente. Para esto, se aplicó un cuestionario a una muestra estadística de 297 trabajadores con 96 % de nivel de confianza y 4 % de margen de error.
Con la información recopilada se construyeron 45 modelos de regresión lineal, y se encontró evidencia estadísticamente significativa de la influencia de la variable predictora sobre la variable dependiente, con valores de correlación r2 entre 0.251 y 0.319. En concreto, se destaca la dimensión de dedicación del engagement como la de mayor influencia por parte de la variable independiente. Además, se observa que la cultura de tipo clan influye de manera más significativa sobre las tres dimensiones de la variable dependiente.
PENGARUH FINANCIAL DISTRESS, TATA KELOLA PERUSAHAAN, DAN PROFITABILITAS TERHADAP PENGHINDARAN PAJAK
Authors: Yantine Melony Nurjul , Rahayuningsih Deasy Ariyanti 
Published: July 2023

Tujuan dari penelitian ini adalah untuk menguji signifikansi pengaruh masing-masing variabel independen. Variabel independen dalam penelitian ini adalah financial distress, kepemilikan manajerial, ukuran dewan direksi, ukuran dewan komisaris independen, komite audit, kepemilikan institusional, dan profitabilitas. Variabel dependen dalam penelitian ini adalah penghindaran pajak. Objek penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2019-2021. Sampel dipilih dengan mempertimbangkan beberapa kriteria dari perusahaan manufaktur periode 2019-2021 yang terdaftar di Bursa Efek Indonesia (BEI), dimana 42 perusahaan memenuhi kriteria dan menghasilkan 126 data sebagai sampel. Hipotesis dalam penelitian menggunakan analisis regresi berganda. Hasil penelitian ini menunjukkan bahwa financial distress memiliki nilai signifikansi sebesar 0,040 dengan koefisien -0,023 dan profitabilitas memiliki nilai signifikansi sebesar 0,012 dengan koefisien -0,507, dimana keduanya memiliki pengaruh positif terhadap penghindaran pajak. Variabel kepemilikan manajerial memiliki nilai signifikansi sebesar 0,297, ukuran dewan direksi memiliki nilai signifikansi sebesar 0,972, ukuran dewan komisaris independen memiliki nilai signifikansi sebesar 0,102, komite audit memiliki nilai signifikansi sebesar 0,153, dan kepemilikan institusional memiliki nilai signifikansi sebesar 0,245, di mana artinya kelima variabel independen tersebut tidak memiliki pengaruh terhadap penghindaran pajak. Penghindaran pajak cenderung dilakukan ketika perusahaan sedang mengalami keterpurukan atau peningkatan dalam hal ekonomi dengan tujuan mengoptimalkan posisi keuangan perusahaan.
Pengaruh Kualitas Produk, Harga dan Kesadaran Merek Terhadap Kepuasan Konsumen
Authors: Suci Suci , Hayati Annur Fitri 
Published: July 2023

The purpose of this study was to determine the effect of product quality, price and brand awareness on consumer satisfaction at Makjus Cake shop consumers in Padang City. The number of research samples was determined based on the William Cochran formula, as many as 97 people and selected using the Purposive Sampling technique. The data used is the type of primary data obtained through the distribution of questionnaires to the people of Padang City with predetermined criteria. The analytical method used is multiple linear regression using SPSS version 21. The results of this study indicate that (1) product quality, price and brand awareness have a significant effect on consumer satisfaction at Makjus Cake shop consumers in Padang City, (2) product quality has a significant effect on consumer satisfaction. consumer satisfaction at Makjus Cake shop consumers in Padang City, (3) price has a significant effect on consumer satisfaction at Makjus Cake shop consumers in Padang City, (4) brand awareness has a significant effect on consumer satisfaction at Makjus Cake shop consumers in Padang City.
Cristianização de escravizados no Brasil do século XVIII e a questão da língua
Authors: Severo Cristine Gorski 
Published: July 2023

Este artigo aborda o lugar das línguas – e da língua portuguesa, mais especificamente – no processo de cristianização de escravizados africanos no Brasil colonial, com enfoque no século XVIII. O texto engloba: (i) uma apresentação panorâmica de instrumentos linguísticos e evangelizadores produzidos pelos missionários católicos, especialmente os jesuítas, caracterizando uma linguística colonial no século XVIII; (ii) uma apresentação das representações e regulamentações da Igreja no Brasil colonial a respeito da cristianização de escravizados africanos. Trata-se de evidenciar o lugar epistemológico e teológico conferido à língua no processo de evangelização, especialmente em um contexto no qual a Igreja católica defendia e buscava justificar a escravização de sujeitos africanos. O artigo contribui para a história social e política das práticas de linguagem no Brasil colonial, com enfoque no contexto católico direcionado à evangelização de sujeitos escravizados. Além disso, o texto contribui para inscrever a dimensão teológica como elemento importante e relevante para a linguística colonial e a historicidade das práticas de linguagem.
Faktor Keperilakuan Yang Memengaruhi Kinerja Keuangan Di BAPPPEDA Provinsi Gorontalo
Authors: Sipatu Intan Sudarniati , Mohamad Roni , Ismail Juniaty 
Published: July 2023

Purpose: This study aims to determine the influence of training factors, clarity of objectives, superior support and the use of information technology on the usefulness of the regional financial accounting system.Design/methodology/approach: The data collection method used in this study is a data collection technique with a questionnaire. Data analysis using multiple linear regression This study used a data analysis method using statistical procedures with SPSS 25.Research Findings: The results showed that there was an effect of training on the usefulness of the regional financial accounting system with a significant value of 0.005 and tcount of 3.021, clarity of objectives had an effect on the use of the regional financial accounting system with a significant value of 0.011 and tcount of 2.694, there was no influence of superior support on the use of the accounting system regional finance with a significant value of 0.133, and there is no effect of the use of information technology on the usefulness of the regional financial accounting system with a significant value of 0.327. Contribution/Originality/Novelty: The results of this study can be used by BAPPEDA in particular and SKPD in Gorontalo Province in general to be used as evaluation material in improving their financial performance by paying attention to aspects of behavior and the use of information technology.
Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui pengaruh faktor pelatihan, kejelasan tujuan, dukungan atasan dan pemanfaatan teknologi informasi terhadap kegunaan sistem akuntansi keuangan daerah.Desain/metodologi/pendekatan: Metode pengumpulan data yang dipergunakan pada penelitian ini ialah teknik pengumpulan data dengan angket atau kuesioner. Analisis data menggunakan regresi linear berganda. Penelitian ini menggunakan metode analisis data mengunakan prosedur statistik dengan bantuan program SPSS 25.Temuan Penelitian: Hasil penelitian menunjukkan terdapat pengaruh pelatihan terhadap kegunaan sistem akuntansi keuangan daerah dengan nilai signifikan 0,005 dan t hitung sebesar 3,021, kejelasan tujuan berpengaruh terhadap kegunaan sistem akuntansi keuangan daerah dengan nilai signifikan 0,011 dan t hitung sebesar 2,694, tidak terdapat pengaruh dukungan atasan terhadap kegunaan sistem akuntansi keuangan daerah dengan nilai signifikan 0,133, serta tidak terdapat pengaruh pemanfaatan teknologi informasi terhadap kegunaan sistem akuntansi keuangan daerah dengan nilai signifikan 0,327.Kontribusi / Orisinalitas / Kebaruan: Hasil penelitian ini dapat digunakan oleh BAPPEDA khususnya dan SKPD di Provinsi Gorontalo pada umumnya untuk dijadikan bahan evaluasi dalam meningkatkan kinerja keuangannya dengan memperhatikan aspek-aspek keperilakuan serta pemanfaatan teknologi informasi.
Study of surface thermodynamic properties of some boron compounds by inverse gas chromatography at infinite dilution
Authors: Hamieh Tayssir 
Published: July 2023

This paper is devoted to the determination of the dispersive component of the surface energy of two boron materials such as h-BN and BPO4 surfaces by using the inverse gas chromatography (IGC) at infinite dilution. The specific interactions and Lewis’s acid-base parameters of these materials were calculated on the light of the new thermal model concerning the dependency of the surface area of organic molecules on the temperature, and by using also the classical methods of the inverse gas chromatography as well as the different molecular models such as Van der Waals, Redlich-Kwong, Kiselev, geometric, Gray, spherical, cylindrical and Hamieh models. It was proved that h-BN surface exhibits higher dispersive surface energy than BPO4 material.The specific properties of interaction of the two boron materials were determined. The results obtained by using the new thermal model taking into account the effect of the temperature on the surface area of molecules, proved that the classical IGC methods, gave inaccurate values of the specific parameters and Lewis’s acid base constants of the solid surfaces. The use of the thermal model allowed to conclude that h-BN surface has a Lewis basicity twice stronger than its acidity, whereas, BPO4 surface presents an amphoteric character.