P1289 Sleep Quality and Associated Factors in Patients with Inflammatory Bowel Disease: A Cross-Sectional Study
Authors: Asgharnezhad M , Maroufizadeh S , Isanazar A , Hedayatzadeh Z , Joukar F , Mansour Ghanaei F 
Published: January 2025

Abstract

Background
Inflammatory bowel disease (IBD), encompassing crohn’s disease (CD) and ulcerative colitis (UC), considerably impacts patients’ quality of life, with sleep disturbances being a prevalent concern. This study aimed to investigate the association between sleep quality and various factors in IBD patients

Methods
A cross-sectional study was conducted involving 307 IBD patients (50 CD and 257 UC) from Guilan province, North of Iran, between 2021 and 2023. Participants were recruited from Razi hospital and the IBD registry of the Gastrointestinal and Liver Diseases Research Center of Guilan University of Medical Sciences. Data were collected using standardized questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9).

Results
The mean age of participants was 45.4 ±13.1 years, most participants (67.1%) were female. The mean global PSQI score was 3.09, indicating that 11.7% of patients experienced poor sleep quality. Notable correlations were found between PSQI scores and GAD-7 (r=0.158, P=0.005) and PHQ-9 scores (r=0.246, P&lt;0.001). Multivariable analysis revealed that each one-point increase in PHQ-9 score was associated with a 0.18-point increase in PSQI score (P&lt;0.001), and patients with comorbidities had PSQI scores 1.32 points higher than those without (P=0.043).

Conclusion
The study highlights a notable prevalence of poor sleep quality among IBD patients, with important associations identified with psychological factors and comorbid conditions. These findings underscore the importance of addressing sleep disturbances in the comprehensive management of IBD, emphasizing the need for targeted interventions to improve sleep quality and overall patient well-being.

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