bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Womb with Rheum: Providers’ Knowledge and Educational Needs in Caring for Women with Rheumatic Diseases
Authors: He Lauren , Arenas Gabriel , Karani Rachel , Faison Maya , Dade Adrianne , Edens Cuoghi 
Published: June 2023

AbstractBackground Patients with rheumatic diseases have unique reproductive health needs. Recent guidelines have been established by various soceities on this topic. However, the education received by women’s health providers pertaining to the recognition and management of common rheumatic diseases in child-bearing age patients is not well-defined. This study aims to assess knowledge gaps, specify aspects of care with greatest uncertainty, and assess current resources used by women’s health providers in the management of their patients with rheumatic disease. Methods An electronic survey was distributed nationally to physicians and allied health professionals who care for reproductive age women. The survey scored participants on their correct responses and confidence ratings in three sections: 1) patients presenting with a new rheumatic disease, 2) contraception in those with a known rheumatic diagnosis, and 3) preconception/antepartum rheumatology medication management. Participants were also asked about resource utilization. Survey questions and scenarios were based on American College of Obstetrics and Gynecology Committee Opinions and the American College of Rheumatology Guidelines for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. Data were captured using RedCap© and analyzed using descriptive statistics. Results The survey was completed by 200 participants with majority being academic obstetricians and gynecologists. Respondents scored the lowest in recognizing new rheumatic disease presentations in peri-and post-partum periods (28.7%, 95% CI: 25.9–31.6%). Contraception counseling was the area of highest accuracy (57.5%, 95% CI: 54.2–60.8%) and confidence (44.6%, 95% CI: 41.7–47.5%), although areas for contraceptive knowledge expansion exist. Approximately 70% of respondents identified online resources as their main resource used in clinical practice and would prefer more information to be provided as a website, published guidelines, or Smartphone application. Conclusions Women’s health providers lack educational opportunities to improve knowledge and confidence in managing reproductive-aged rheumatic diseases patients. Recognizing new disease presentations and antepartum medication management were identified as topics with the largest knowledge gaps. Collaborative resources are needed to fill educational needs.
HDL suppresses dendritic cell maturation and modulates CD4+ T cell subtypes against inflammatory in a mouse model of rheumatoid arthritis
Authors: Wang Xin , Lu Shulai , Li Dong , Zhang Juan , Dong Qingzhe , Jia Dongmei , Wang Yunlong , Liu Bin 
Published: June 2023

Abstract
Background: To investigate the mechanism of anti-inflammatory effect of High-density lipoprotein (HDL) in collagen-induced arthritis (CIA) mice.
Methods: The CIA animal model was constructed, and the mice were separated into three groups: control, CIA and CIA + HDL. In the CIA + HDL group, HDL was given on day 40, and an additional injection was administered every 3 days for a total of five doses. The levels of mouse HDL were measured by using ELISA kits, and liver, heart, kidney and colon tissue sections were stained with H＆E. Additionally, the splenic CD4+ T cell phenotypes in each group were analyzed. Immature DCs were stimulated with LPS in the presence or absence of HDL, and the expression of surface markers was investigated by FACS.
Results: HDL decreased the ratio of Th1/Th2 cells and increased the Th1/Th17 cell ratio in the CIA + HDL group compared with those of the CIA one (P<0.05). In vitro, the expression of MHC-II, CD86, and CD40 in CD11c+ BMDCs was suppressed by HDL. The level of HDL in the CIA group was significantly reduced compared with that of the control one (P<0.05), and there were no significant pathological changes in the liver, heart, kidney and colon tissues of the mice among the three groups.
Conclusion: HDL exerts anti-inflammatory effect in CIA mice by suppressing DCs maturation and modulating CD4+ T cell subtypes.
Insights on Cloud Computing: a bibliometric analysis
Authors: Nallola Sandhya Rani , Ayyasamy Vadivel 
Published: June 2023

Abstract
The goal of the study is to assess the volume of research on Cloud Computing (CC) and, using bibliometric analysis, to discover study patterns, growth, and evolution in the Scopus database. This study's main goal is to undertake a thorough bibliometric analysis of works that concentrate on the use, identification, network structure, and conceptual framework of CC. With the aid of an electronic search, the most pertinent articles were located. The Scopus database served as the source for the studies that will be reviewed. Between 2009 and 2023, 1,361 articles were discovered and reduced to 1009 papers. With the aid of the R programming language and the VOSviewer software, each composition has been examined in terms of co-authorship, co-citation, conceptual structure, co-word occurrence, trend topics analysis, thematic map, topic dendrogram, three field plot diagram, and visualization analysis. The rise in researchers' multi-authored, interdisciplinary, and collaborative efforts likewise showed an annual growth rate of 18.28%. Overall, this study improved knowledge of the cloud computing phenomena and helped to evaluate a variety of statistics based on publications and citations. This study contributes to our understanding of the networks of collaboration among various scholars and institutions, as well as the advantages and disadvantages of working cross-disciplinarily, globally, or with corporate or industry institutions.
A putatively new ant species from the Cataglyphis cursor group displays low levels of polyandry with standard sexual reproduction
Authors: Doums Claudie , Chifflet-Belle Pascaline , Lenormand Thomas , Boulay Raphael , Villalta Irène 
Published: June 2023

Abstract
How social organisation (number of queens and mating partners) and reproductive systems (use of thelytoky vs sex) evolved in ants and how they interplay is still far from clear. The Cataglyphis desert ants represent a fascinating group as it harbours variation in both levels of polyandry and the use of thelytoky, with polyandry and sexual reproduction probably being the ancestral state. In this study, we compared the colony and population genetic structure of two populations of the Cataglyphis cursor group distributed in a remote small geographic area in central Spain with those of their geographically closest species C. piliscapa and C. cursor. Not surprisingly, we found that the two populations are genetically isolated from those of C. piliscapa and C. cursor, both for the mtDNA and microsatellite markers. Interestingly, we observed a lower level of polyandry in the C. cursor from Spain even though the population genetic diversity was like C. piliscapa and C. cursor. Queens did not appear to use frequently thelytoky which supports the hypotheses that low levels of polyandry disfavours the use of thelytoky. Reversion to a lower level of polyandry has rarely been observed in ants, and we discuss multiple hypotheses that could explain this phenomenon. Whether these remote populations belong to a putatively new species requires a careful taxonomic investigation. Our study highlights the lability of the reproductive system in this group and provides an exciting system to investigate the co-evolution of polyandry and thelytoky.
Rocket Nozzle Performance Optimization Using Modified Turbulence
Authors: M Manoj , Farouk Rameez , J Bruce Ralphin Rose , R Jinu G 
Published: June 2023

Abstract
Vortex generators are widely used for enhancing the nozzle thrust output by creating different effects. The Ranque-Hilsh effect is observed in a swirling nozzle flow within a single tube is a spontaneous separation of total temperature. Here the colder stream near the tube centre line and the hotter air near its periphery. Hence the temperature difference due to the presence of disturbed flow can either increase (or) decrease the thrust output. This analysis is made of the velocity, temperature and pressure distribution in a turbulent vortex with radial and axial flow. The controlled flow expansion by modifying the geometry in the downstream of throat region can yield better shock expansion characteristics. The most important factor affecting the total temperature of a fluid element in a compressible vortex is the turbulent shear work done on or by the element. The parameter which is considered for this optimization of the vortex generator is exit nozzle opening area, Efficiency of Energy Separation, Profile of velocity, temperature, Length of the tube. Further the experimental investigation of output mass flow rate by geometry modification also will be studied. Computational Fluid Dynamics (CFD) based optimization procedure using the Parabolized Navier-Strokes (PNS) equation is used to design axisymmetric nozzle. The advantage of this procedure is that it accounts for viscosity during the design process. Remaining process will make an approximated Boundary Layer Correction after the inviscid design is created. The nozzle design begins with concerning control volume and the separation of Aerodynamic and Propulsive forces and moments will be demonstrated. The appropriate control volume can define the propulsive force vector that maximizes cruise efficiency. The different boundary layer thickness must be evaluated at various temperature and pressure conditions. Then the influence of boundary layer thickness in the net output will be evaluated numerically. The nozzle configuration of a truncated perfect nozzle is selected for computations. The starting process of unsteady flow characteristics and flow separation are observed carefully. The reattachment of the flow through nozzle is also visualized using the computational analysis.
No Evidence of Structural Abnormality of the Substantia Nigra in Adult Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Cohort Study
Authors: Friedrich Isabel , von Kuenheim Daniela , Wozniak David , Meyer Patrick , Mauche Nicole , Huang Jue , Classen Joseph , Strauss Maria , Rumpf Jost-Julian 
Published: June 2023

Abstract
Background Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder that has recently been associated with an increased risk of developing movement disorders such as Parkinson's disease (PD), particularly in individuals treated with psychostimulants. Abnormal expansion of the echogenic area of the substantia nigra (SN), a trait marker for PD, is also commonly found in children with ADHD, in whom this feature was attributed to maturational delay of the dopaminergic system. Here, we investigated the structural integrity of the SN in adults with ADHD and its relationship to symptomatic treatment with psychostimulants.Methods In this cross-sectional cohort study, we performed transcranial sonography of the SN in 30 adults (mean age 33.3 ± 7.6 years, 11 females) diagnosed with ADHD according to DSM-V criteria. The cumulative dose of methylphenidate was extrapolated based on the treating physicians’ documentation and patient’s reports.Results The mean echogenic SN area in our cohort amounted to 0.17 ± 0.04 cm² (mean ± standard deviation), which is well within the normal range of echogenic SN area according to consensus criteria and did not significantly differ from the mean echogenic SN area observed in two independent control groups previously collected at our site (all p ≥ 0.297). Importantly, we observed no significant treatment-associated changes of SN echogenicity with respect to the extrapolated cumulative dose of methylphenidate derivates (r=-0.261, p = 0.163).Conclusions Our results indicate that expansion of the echogenic SN area is, unlike evidence in children with ADHD, not useful as an ADHD biomarker in adults. The current results, furthermore, challenge the view that abnormal expansion of the echogenic SN in ADHD may reflect maturational delay of the dopaminergic system, at least it does not persist into adulthood. Therefore, if there is an intrinsic link between ADHD and PD, it is not reflected by structural alterations of SN echogenicity. Importantly, we found no evidence of treatment-associated changes in structural SN integrity mitigating concerns about a possible causal relationship between therapeutic psychostimulant use in ADHD and an increased risk of PD.
Dynamics of Belief: Abduction, Horn Knowledge Base And Database Updates
Authors: Delhibabu Radhakrishnan 
Published: June 2023

Abstract
The dynamics of belief and knowledge is one of the major components of any autonomous system that should be able to incorporate new pieces of information. In order to apply the rationality result of belief dynamics theory to various practical problems, it should be generalized in two respects: first it should allow a certain part of belief to be declared as immutable; and second, the belief state need not be de-ductively closed. Such a generalization of belief dynamics, referred to as base dynamics, is presented in this paper, along with the concept of a generalized revision algorithm for knowledge bases (Horn or Horn logic with stratified negation). We show that knowledge base dynamics has an interesting connection with kernel change via hitting set and abduction. In this paper, we show how techniques from disjunctive logic programming can be used for efficient (deductive) database updates. The key idea is to transform the given database together with the update request into a disjunctive (datalog) logic program and apply disjunctive techniques (such as minimal model reasoning) to solve the original update problem. The approach extends and integrates standard techniques for efficient query answering and integrity checking. The generation of a hitting set is carried out through a hyper tableaux calculus and magic set that is focused on the goal of minimality. The present paper provides a comparative study of view update algorithms in rational approach. For, understand the basic concepts with abduction, we provide an abductive framework for knowledge base dynamics. Finally, we demonstrate how belief base dynamics can provide an axiomatic characterization for insertion a view atom to the database. We give a quick overview of the main operators for belief change, in particular, belief updates versus database updates.
High-temperature measurements on viscosity and surface tension of the ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][NTf2]) up to 473 K
Authors: Zhai Ziwen , Koller Thomas M. 
Published: June 2023

Abstract
In the present study, the viscosity and surface tension of the commercial low-viscosity ionic liquid (IL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([EMIM][NTf2]) were determined by a combination of surface light scattering (SLS) and the pendant-drop (PD) method between (303 and 473) K. Both methods operating at thermodynamic equilibrium were applied inside the same measurement cell at identical experimental conditions under an argon atmosphere at 0.1 MPa. For SLS measurements performed in the temperature range from (303 to 323) K, the overdamped behavior of the surface fluctuations allowed access to the viscosity with an expanded uncertainty of 2.3% by using the surface tensions determined via the PD method with an uncertainty of 2% as input quantities. Above 323 K up to 473 K, the oscillatory behavior of the probed surface fluctuations by SLS enabled a simultaneous determination of viscosity and surface tension with average expanded uncertainties of (4 and 3) %, respectively. Multiple repetition measurements by both methods have been conducted at 323 K after experiments at larger temperatures up to 473 K, and the consistency of their results could indicate a sound thermal stability of the IL sample. The mutual agreement of the surface tension results from SLS and the PD method between (353 and 473) K demonstrates that both techniques analyze the very same IL surface. For both properties, the results from this work agree well with the majority of experimental data reported in the literature typically up to 353 K. In summary, the viscosity and surface tension results presented in this study contribute to an improved data landscape for this particular IL and ILs in general at elevated temperatures.
Cancer Stem Cells Remodel the Tumor Microenvironment and Influence Immunotherapy Response in Hepatocellular Carcinoma
Authors: Zhang Xianzhou , Yang Nanmu , Zhuang Hao , Han Feng , Meng Bo 
Published: June 2023

Abstract
Background: Cancer stem cells are the important factors that lead to drug resistance, recurrence and metastasis of tumor. Immunotherapy has become the first-line treatment for advanced Hepatocellular Carcinoma(HCC), however, the importance of cancer stem cells in the immunotherapy of HCC has not been well elucidated.
Methods: We identified a subset of cells with stemness characteristics by analyzing single-cell sequencing data from tumor tissue samples from 10 patients with HCC. We screened these cell populations for overexpressed genes, defined as cancer stem cell-related genes. Subsequently, we comprehensively analyzed the bulk RNA sequencing data of 365 HCC patients to construct a cancer stem cell-related genes prognostic signature(CSGPS). According to the CSGPS, 365 patients with HCC were divided into high-risk and low-risk groups. Multiple independent external cohorts were used to assess the predictive value of the CSGPS. T cell receptor (TCR) richness, Cancer Testicular Antigens (CTA) scores, Microsatellite instability (MSI), expression of immune checkpoint-related genes, and Tumour Immune Dysfunction and Exclusion (TIDE) scores were used to assess the intensity of response to immunotherapy in different risk groups. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to verify the mRNA expression levels of cancer stem cell-related genes in HCC tissues.
Results: CSGPS is an independent risk factor for the prognosis of HCC patients, and it is significantly superior to other clinical features in predicting the prognosis and immunotherapy response of HCC patients. Multiple independent external cohorts validated the validity and robustness of the CSGPS. Immune infiltration analysis showed that cancer stem cell-related genes can recruit immune cells with immunosuppressive functions, such as Treg, macrophages infiltration. The CSGPS was correlated with the TCR, CTA score, MSI score, expression of immune checkpoint-related genes, and TIDE score. Patients in the high-risk group identified by the CSGPS may respond more strongly to immunotherapy and be more suitable to immunotherapy. The results of qRT-PCR confirmed that 8 cancer stem cell-related genes were overexpressed in HCC tissues.
Conclusion: Cancer stem cell-related genes are overexpressed in HCC and contribute to the formation of an immunosuppressive microenvironment. Targeting cancer stem cells may become a new target for immunotherapy of HCC. Our novel prognostic signatureof cancer stem cell-related genes can effectively predict the prognosis and immunotherapy response of HCC patients. In the future, the prognostic signature will help clinicians to select the appropriate population for immunotherapy and improve the response rate of immunotherapy.
Signalling Pathway Associated to Discharge of Cnidocyst Induced by Reduced Glutathione in Hydra
Authors: GAVAZZI María Victoria , RONDEROS JORGE RAFAEL , Alzugaray María Eugenia 
Published: June 2023

Abstract
In the present work we study the effect of different stimuli (living preys, its homogenate, and reduced glutathione (GSH)) on the discharge of desmonemes in the freshwater cnidarian, Hydra plagiodesmica. Once confirmed their stimulatory effect, we choose GSH in order to analyse the relevance of Ca2+, the probable identity of the sensory receptor molecule, and the specific signalling pathway driving the discharge mechanism. Our results show that not only mechanical, but also chemical stimuli by itself may stimulate the discharge of desmonemes. Using calcium chelators, we verify that the discharge mechanism triggered by GSH, is dependent on calcium. By mean of drugs that inhibit proteins pertaining to canonical signalling pathways, including GPCRs, we show that GSH causes the influx of Ca2+ via L-type VGCC, and its release by mean of endoplasmic reticulum calcium channels. Moreover, our results suggest that the putative receptor for GSH is a GPCR coupled to Gq, which produces IP3 and Ca2+ as second messengers. Finally, we show that the genome of Hydra predicts the existence of the different subunits of L-type VGCC, showing a high level of conservation when compared with other groups of Metazoa.
Assisting In-Silico Drug Discovery Through Protein-Ligand Binding Affinity Prediction By Convolutional Neural Networks
Authors: Rayka Milad , Latifi Ali Mohammad , Mirzaei Morteza 
Published: June 2023

Abstract
Context:
In this paper, we present a new feature-generating method based on distance-weighted atomic contact to predict the binding affinity between ligands and proteins in structure-based drug design, which can distinguish between weak and strong interactions. We discuss the significance and challenges of predicting binding affinity and how recent advances in hardware and deep learning algorithms have led to the surge of applying these techniques in drug design.
Methods:
We utilize the PDBbind 2016 dataset for training our model. Our approach involves using a convolutional neural network architecture to predict the binding affinity between ligands and proteins. We investigate the impact of choosing the architecture on the performance of the model. Our best model, the Sequential Model, produces Pearson's correlation of 0.79 on the independent core set. Our results suggest that a vanilla and shallow convolutional network has more acceptable performance than a more complicated architecture specifically for this problem.
Transapical Transcatheter Aortic Valve Replacement for Severe Aortic Regurgitation in Dextrocardia: A case report
Authors: Yu Junjian , Yu Wenbo , Xiong Jianxian 
Published: June 2023

Abstract
Dextrocardia is a rare congenital cardiovascular malformation in which the heart is located on the right side of the thoracic cavity, with an occurrence of approximately 2/100,000. The clinical understanding of such lesions is also increasing with the continuous development of cardiovascular diagnosis and treatment technologies, and dextrocardia combined with aortic regurgitation is rare, so the treatment of such patients is usually complicated.