bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Functionalized Pyrimidines from Propargylic alcohols and their Derivatives: Two Decades of Developments
Authors: Mishra Surabhi , Raikwar Sumran , Baire Beeraiah 
Published: May 2023

AbstractPyrimidine is a six‐membered diaza‐heterocycle i. e., 1,3‐diazine. It is found to be present in many biologically and pharmacologically active scaffolds like nucleotides, natural products, and drugs. The bioactivities of pyrimidine include anti‐tubercular, anti‐bacterial, anti‐fungal, anti‐viral, anti‐inflammatory, anti‐malarial, anti‐cancer, anti‐neoplastic and many more. In this review article we have summarized various synthetic approaches that involve the synthesis of these privileged building blocks by employing propargylic alcohols and their derivatives like propargylic esters and propargylic ynones as three carbon‐components. Here, we have confined ourselves to the developments appeared during the period of 23 years i. e., 2000–2022.
Phase‐Controlled Pd‐Sn Nanostructures via Co‐Digestive Ripening: Catalytic Performance for Base‐Free Oxidation of Benzyl Alcohol
Authors: Bhatia Geetanjali , Jagirdar Balaji R. 
Published: May 2023

AbstractDiluting the precious metal to be used for catalysis with an abundant and non‐precious metal to form alloy/intermetallic nanostructures is of great interest owing to the cost‐effectiveness of the catalyst. The physicochemical properties of such bimetallic nanostructures are influenced by the atomic ordering of different atoms in the system, generally enhancing the catalytic activity, selectivity, and durability compared to their monometallic counterparts. To understand the relationship between the structure and the activity of the catalyst, phase‐controlled synthesis of alloy/intermetallic nanostructures is crucial. Easy and scalable synthesis of such nanostructures with phase control presents a true challenge. We exploited a colloidal‐based synthetic route termed ‘co‐digestive ripening’ to prepare Pd−Sn alloy/intermetallic nanostructures. Oleylamine capped Pd and Sn colloids were utilized to obtain network‐like Pd3Sn and grape‐like Pd2Sn nanostructures. Temperature and the stoichiometric ratio between Pd and Sn played significant roles in achieving phase control. The mixture of ligands (oleylamine and trioctylphosphine) in the synthetic procedure resulted in the formation of well‐separated nanoparticles (2.9±0.5 nm) in the case of Pd3Sn and few nm‐sized particles along with aggregates in the case of Pd2Sn. Pd−Sn nanostructures showed enhanced activity and selectivity as compared to their monometallic counterparts for the catalytic performance towards oxidation of benzyl alcohol.
In‐Site Grown NiFeOOH Nanosheets Foam Directly as Robust Electrocatalyst for Efficient Urea Oxidation Application
Authors: Feng Wenshuai , Bu Manman , Zhang Yue , Li Yejun , Gao Xiaohui , Liu Hongtao 
Published: May 2023

AbstractIn this work, a series of morphology‐controlled NiFeOOH nanosheets were directly developed through a one‐step mild in‐situ acid‐etching hydrothermal process. Benefiting from the ultrathin interwoven geometric structure and most favorable electron transport structure, the NiFeOOH nanosheets synthesized under 120 °C (denoted as NiFe_120) exhibited the optimal electrochemical performance for urea oxidation reaction (UOR). An overpotential of merely 1.4 V was required to drive the current density of 100 mA cm−2, and the electrochemical activity remains no change even after 5000 cycles’ accelerated degradation test. Moreover, the assembled urea electrolysis set by using the NiFe_120 as bifunctional catalysts presented a reduced potential of 1.573 V at 10 mA cm−2, which was much lower than that of overall water splitting. We believe this work will lay a foundation for developing high‐performance urea oxidation catalysts for the large‐scale production of hydrogen and purification of urea‐rich sewage.
Improved Gaussian filtering for handling concurrent delayed and missing measurements
Authors: Kumar Guddu , Naik Amit Kumar , Pachori Ram Bilas , R Swaminathan , Singh Abhinoy Kumar 
Published: May 2023

AbstractThis article addresses the Gaussian filtering problem under the environment of jointly occurring delayed and missing measurements. In this work, the former irregularity is incorporated (in the measurement model) using a Bernoulli random variable (BRV) and a geometric random variable, while the latter is subsumed with the help of the BRV; thereby, it enables to take account of large delay extents efficiently. Specifically, a modified measurement model, which incorporates the concerned irregularities, is introduced. Accordingly, the measurement‐related statistical parameters, that is, measurement estimate, covariance, and cross‐covariance, are rederived with respect to the modified measurement model. The rederived parameters replace the corresponding ones in the traditional Gaussian filtering algorithm, resulting in the proposed Gaussian filter. The simulation results conclude the superior performance of the proposed filter over the existing filters in handling the coexisting delay and missing measurement irregularities.
Modeling the evolution of recombination plasticity: A prospective review
Authors: Rybnikov Sviatoslav R. , Frenkel Zeev , Hübner Sariel , Weissman Daniel B. , Korol Abraham B. 
Published: May 2023

AbstractMeiotic recombination is one of the main sources of genetic variation, a fundamental factor in the evolutionary adaptation of sexual eukaryotes. Yet, the role of variation in recombination rate and other recombination features remains underexplored. In this review, we focus on the sensitivity of recombination rates to different extrinsic and intrinsic factors. We briefly present the empirical evidence for recombination plasticity in response to environmental perturbations and/or poor genetic background and discuss theoretical models developed to explain how such plasticity could have evolved and how it can affect important population characteristics. We highlight a gap between the evidence, which comes mostly from experiments with diploids, and theory, which typically assumes haploid selection. Finally, we formulate open questions whose solving would help to outline conditions favoring recombination plasticity. This will contribute to answering the long‐standing question of why sexual recombination exists despite its costs, since plastic recombination may be evolutionary advantageous even in selection regimes rejecting any non‐zero constant recombination.
Psychometric assessment of the Persian version of the protective factors of resilience scale (PFRS)
Authors: Gheisari Zahra , Abdollahi Abbas , Hashemi Zahra 
Published: May 2023

AbstractBackgroundResilience is defined as an individual's ability to recover from difficulties and overcome challenges and adversity. Recognizing and measuring internal and external protective factors have been identified as important processes for building resilience, yet to date, no valid, and reliable scales of resilience in the Persian language have been developed that recognize both internal and external protective factors.MethodsThe present study was to translate the protective factors of resilience scale (PFRS) from English to Persian and analyze its psychometric properties among Iranians. Convenience sampling was used to gather data from January 2021 to February 2021 through digital internet scales, and 6 scales, including PFRS, Ryff's psychological well‐being scale, Rosenberg self‐esteem scale, life orientation test‐revised, positive and negative affect schedule, and short version of resilience scale (RS), were completed by 265 participants aged from 15 to 56. So, the aim of this study is to investigate the psychometric properties of protective factors of resilience scale among Iranians.ResultsThe results of the face, content, and construct validity revealed that the Persian version of the PFRS measure had acceptable validity and reliability. The Cronbach alpha for the whole scale was 0.88, and the value of the content validity index was above 0.7. A confirmatory factor analysis confirmed the three‐factor structure model of the scale (fit indices: CMIN/df = 2.51, p < .01; comparative fit index = 0.94, goodness of fit index = 0.90, root mean squared error of approximation = 0.07).ConclusionIn conclusion, the Persian version of the protective factors of resilience is a reliable and valid measurement to assess the protective factors and internal and external protective factors of resilience in Iranians.
Lived experience of persons with multiple sclerosis: A qualitative interview study
Authors: Persson Sofia , Andersson Ann‐Christine , Gäre Boel Andersson , Lindenfalk Bertil , Lind Jonas 
Published: May 2023

AbstractIntroductionMultiple sclerosis (MS) is a chronic autoimmune disease with a substantial impact on quality of life and functional capability. The prognosis of MS has changed over time due to the development of increasingly effective therapies. As the knowledge and perceptions of persons living with chronic conditions increasingly have been acknowledged, it has become important to understand lived experiences with a focus on everyday events and experiences as a way of knowing and interpreting the world. Exploring context‐specific lived experiences as a source of knowledge about the disease and care may contribute to more precision in designing care services. The aim of this study was to explore the lived experience of persons living with MS in a Swedish context.Materials and methodsA qualitative interview study was conducted with both purposeful and random sampling strategies, resulting in 10 interviews. Data were analyzed using inductive thematic content analysis.ResultsThe analysis generated 4 overarching themes with 12 subthemes, the 4 themes were: perspectives on life and health, influence on everyday life, relations with healthcare, and shared healthcare processes. The themes are concerned with the patients’ own perspectives and context as well as medical and healthcare‐related perspectives. Patterns of shared experiences were found, for example, in the diagnosis confirmation, future perspectives, and planning and coordination. More diverse experiences appeared concerning relations with others, one's individual requirements, symptoms and consequences, and knowledge building.ConclusionThe findings suggest a need for a more diverse and coproduced development of healthcare services to meet diverse needs in the population with greater acknowledgement of the person's lived experience, including consideration of the complexity of the disease, personal integrity, and different ways of knowing. Findings from this study will be further explored together with other quantitative and qualitative data.
Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of Zebrafish
Authors: Vaithiyalingam Mariyappan , Mohan Kumar Ramasamy , Kamaraj Chinnaperumal , Sugumar Vimal , Manivannan Nandhagopal , Kadaikunnan Shine , Ghodake Gajanan 
Published: May 2023

AbstractCitral (1a), a bioactive component of Cymbopogon citratus (lemongrass) could be isolated and semi‐synthetic analogs synthesized with improved therapeutic properties. Herein we first report describes citral (1a) as a primary material for the synthesis of benzimidazole derivatives between various o‐phenylenediamines (2a–l) in the presence of Diisopropylethylamine (DIPEA) as a commercially available environmentally benign base, ethanol as a green solvent and the yield of all benzimidazole derivatives (3a–l) was between 68–76 %; The semi‐synthetically prepared benzimidazole derivatives (3a–l) were assessed for their anti‐bacterial and anti‐fungal properties. The benzimidazole compounds (3a–b, and 3g–j) exhibit good anti‐microbial activity. In addition, in silico study was carried out to determine the specific binding affinity of the diamine halogen substituted benzimidazole derivatives to the specific target proteins. In silico analysis revealed a high correlation between docking results and experimental results. Finally, benzimidazole demonstrated significant antibacterial and antifungal activity. Zebrafish embryos were subjected to In vivo toxicological test found that all of the benzimidazole compounds (3a–l) were non‐toxic and had low embryotoxicity after 96 h, with an LC50 of 36.425 μg, which could facilitate the design of novel antimicrobial agents using a cost‐effective method.
New Meroterpenoids and Anti‐Osteoclastogenic Polyketides from the Mangrove‐Derived fungus Arthrinium sp. SCSIO 41306
Authors: Hu Yiwei , Qi Xin , Chen Weihao , Liao Shengrong , Yang Dehua , Wang Mingwei , Liu Yonghong , Tan Yanhui , Wang Junfeng 
Published: May 2023

AbstractTwo new meroterpenoids, arthrinones A and B (1 and 2), along with six known compounds (3–8), were obtained from the fungus Arthrinium sp. SCSIO 41306. Comprehensive methods such as chiral‐phase HPLC analysis and ECD calculations were applied to determine the absolute configurations. Griseofulvin (5), kojic acid (6), and 1H‐indole‐3‐carboxaldehyde (8) showed inhibition of NF‐κB in RAW 264.7 macrophages induced by lipopolysaccharide (LPS) with IC50 values of 22.21, 13.87 and 19.31 μM, respectively. In addition, griseofulvin (5) inhibited receptor activator of NF‐κB ligand (RANKL)‐induced osteoclast differentiation in a dose‐dependent manner without visible evidence of cytotoxicity in bone marrow macrophages (BMMs). This is the first report on the activity of griseofulvin (5) to inhibit osteoclast formation (IC50 10.09±0.21 μM).
Nanoparticles zinc paste bandages for the treatment of Syrian woman diabetic patient with ulcers in the foot: Case images
Authors: Alwis Reham , Alwis Razan , Al‐Raeei Marwan 
Published: May 2023

Key Clinical MessageTreatments of secondary diseases such as the ulcer in the skin and thromboembolic diseases in the venous are significant procedures for lots of patients of main diseases which cause them. Herein, effective nano‐particles are used for the treatment.
The emergence of unique elective identities in the professional identity development research in the counseling profession
Authors: Gibson Donna M. , Dollarhide Colette T. , Brashear Kayleena , Huynh Jenny , Marshall Bowen , Robinson Kristian 
Published: May 2023

AbstractIn this study, a qualitative content analysis of the professional identity development research in counseling was conducted to describe elements of the development of “elective identities” of leader, research, counselor educator, and social justice practitioner. Predisposing, process, and outcome codes reveal experiences and contexts that influence this development in students, educators, and counselors.
Tuning the Polarity of Antibiotic‐Cy5 Conjugates Enables Highly Selective Labeling of Binding Sites
Authors: Graßl Fabian , Konrad Maike M. B. , Krüll Jasmin , Pezerovic Azra , Zähnle Leon , Burkovski Andreas , Heinrich Markus R. 
Published: May 2023

AbstractMultidrug‐resistant bacteria pose a major threat to global health, even as newly introduced antibiotics continue to lose their therapeutic value. Against this background, deeper insights into bacterial interaction with antibiotic drugs are urgently required, whereas fluorescently labeled drug conjugates can serve as highly valuable tools. Herein, the preparation and biological evaluation of 13 new fluorescent antibiotic‐Cy5 dye conjugates is described, in which the tuning of the polarity of the Cy5 dye proved to be a key element to achieve highly favorable properties for various fields of application.
An editorial on a comparison of care quality metrics between Black and White men with advanced prostate cancer in the IRONMAN registry
Authors: Murphy Adam B. 
Published: May 2023

Plain Language Summary

This editorial highlights key findings from the manuscript entitled “Experience with the US health care system for Black and White patients with advanced prostate cancer” in the Cancer journal. Namely, the Black men and White men recruited in US sites for the International Registry for Men with Advanced Prostate Cancer (IRONMAN) registry reported similar and mainly affirmative responses for health care quality metrics on a survey.
In non–National Cancer Institute–designated centers, the care was actually worse for the White participants than for the Black participants. The study's results suggest that clinical trial enrollment may be a way to improve health care quality and eliminate disparities for Black men.
Whether this healthcare quality benefit extends beyond the few IRONMAN recruitment sites where Black men were recruited or beyond a few measures of healthcare quality remains to be seen.
A phase 2 multicenter study of docetaxel‐PM and trastuzumab‐pkrb combination therapy in recurrent or metastatic salivary gland carcinomas
Authors: Lee Jiyun , Park Sehhoon , Jung Hyun Ae , Lee Se‐Hoon , Seo Seyoung , Kim Sung‐Bae , Kim Ji‐Won , Lee Keun‐Wook , Kang Eun Joo , Kim Ju Won , Choi Yoon Ji , Shim Byoung‐Yong , An Ho‐Jung , Park Lee Chun , Shin Seong Hoon , Kim Jae‐Joon , Oh So Yeon , Kim Min Kyoung , Ahn Myung‐Ju 
Published: May 2023

AbstractBackgroundSalivary duct carcinoma (SDC) is uncommon but is the most aggressive subtype of salivary gland carcinomas. The high positivity rate for human epidermal growth factor receptor 2 (HER2) led to an investigation of the efficacy of HER2‐targeted agents. Docetaxel‐PM (polymeric micelle) is a low‐molecular‐weight, nontoxic, biodegradable, and docetaxel‐loaded micellar formulation. Trastuzumab‐pkrb is a biosimilar to trastuzumab.MethodsThis was a multicenter, single‐arm, open‐label phase 2 study. Patients with HER2‐positive (immunohistochemistry [IHC] score of ≥2+ and/or HER2/chromosome enumeration probe 17 [CEP17] ratio of ≥2.0) advanced SDCs were enrolled. Patients received docetaxel‐PM (75 mg/m2) and trastuzumab‐pkrb (8 mg/kg in the first cycle and 6 mg/kg in subsequent cycles) every 3 weeks. Primary end point was objective response rate (ORR).ResultsA total of 43 patients were enrolled. The best objective responses were partial response in 30 (69.8%) patients and stable disease in 10 (23.3%) patients, leading to an ORR of 69.8% (95% confidence interval [CI], 53.9–82.8) and a disease control rate of 93.0% (80.9–98.5). Median progression‐free survival, duration of response, and overall survival were 7.9 (6.3–9.5), 6.7 (5.1–8.4), and 23.3 (19.9–26.7) months, respectively. Patients with HER2 IHC score of 3+ or HER2/CEP17 ratio ≥2.0 demonstrated better efficacies compared to those with HER2 IHC score of 2+. Thirty‐eight (88.4%) patients experienced treatment‐related adverse events (TRAE). Because of TRAE, nine (20.9%), 14 (32.6%), and 19 (44.2%) patients required temporary discontinuation, permanent discontinuation, or dose reduction, respectively.ConclusionsThe combination of docetaxel‐PM and trastuzumab‐pkrb demonstrated promising antitumor activity with a manageable toxicity profile in HER2‐positive advanced SDC.Plain Language Summary

Salivary duct carcinoma (SDC) is uncommon but is the most aggressive subtype of salivary gland carcinomas.

SDC shares morphological and histological similarities with invasive ductal carcinoma of breast, which led to an investigation of hormonal receptor and human epidermal growth factor receptor 2 (HER2)/neu expression status in SDC.

In this study, patients with HER2‐positive SDC were enrolled and treated with combination of docetaxel‐polymeric micelle and trastuzumab‐pkrb.

Promising antitumor activities were shown with objective response rate of 69.8%, disease control rate of 93.0%, median progression‐free survival of 7.9 months, median duration of response of 6.7 months, and median overall survival of 23.3 months.
Atypical urothelial cells classified according to the Paris System for Reporting Urinary Cytology: A 2‐year experience with histological correlation from a Finnish tertiary care center—low rate and high risk of malignancy
Authors: Pöyry Emilia , Nykänen Veera , Pulkkinen Johanna , Viljanen Eliisa , Laurila Marita , Kholová Ivana 
Published: May 2023

AbstractBackgroundThe Paris System for Reporting Urinary Cytology (TPS) was issued to shift the focus of urine cytology to high‐grade lesions to increase the diagnostic accuracy of urine cytology. The aim of this study was to evaluate the power of TPS in the atypical urothelial cells (AUC) category with histological correlation and follow‐up.MethodsThe data cohort consisted of 3741 voided urine samples collected during a 2‐year period between January 2017 and December 2018. All samples were prospectively classified using TPS. This study focuses on the subset of 205 samples (5.5%) classified as AUC. All cytological and histological follow‐up data were analyzed until 2019, and the time between each sampling was documented.ResultsOf the 205 AUC cases, cytohistological correlation was possible in 97 (47.3%) cases. Of these, 36 (12.7%) were benign in histology, 27 (13.2%) were low‐grade urothelial carcinomas, and 34 (16.6%) were high‐grade urothelial carcinomas. Overall, the risk of malignancy was 29.8% for all cases in the AUC category, and 62.9% in the histologically confirmed cases. The risk of high‐grade malignancy was 16.6% in all the AUC category samples and 35.1% in the histological follow‐up group.ConclusionsThe performance of 5.5% AUC cases is considered good and within the limits proposed by TPS. TPS is widely accepted by cytotechnologists, cytopathologists, and clinicians; it improves communication and patient management.
In‐situ technical study of contemporary painting from the heritage collection of the Universitat de València, Spain. Canvases and colorful landscapes by Manuel Moreno Gimeno
Authors: Vázquez de Ágredos Pascual Ma. Luisa , Solbes García Álvaro , Ramacciotti Mirco , Gallello Gianni , Sala Susana Herreras , Iranzo Lucía Rojo , Nuno María Andrieux , Garay Juan Carlos Izquierdo , Nieto Villena Alejandra 
Published: May 2023

AbstractThe Universitat de València brings together artistic collections of great value that embrace more than five centuries of history (1499–2022). Among them, the collection of contemporary painting stands out for its diversity of artists, artistic techniques and themes. One of the aims of the Vice‐rectorate for Culture and Society of the Universitat de València is the study, conservation and dissemination of its art collection, implementing innovative methodologies that will place these artworks at the research and transfer frontline. To achieve this, the Laboratory for Analysis and Diagnosis of Works of Art of the Universitat de València: Conservation, Legacy, InnOvation has recently optimized a multi‐analytical artistic diagnosis approach that combines the use of multiband technical photography (MTP) with digital radiography, infrared reflectography (IRR) and hyperspectral camera. The noninvasive methodology developed for the studied paintings, belonging to different historical periods, is completed by using a portable X‐ray fluorescence. The final goal is to obtain useful information on the composition and execution technique, issues of great interest for developing preventive conservation plans for the collections and for the design of innovative exhibition proposals of an immersive and accessible nature. This article presents the results obtained for three paintings that were made by one of the most unknown Valencian painters of the early 20th century, despite the great quality of his work: Manuel Moreno Gimeno (1900–1982). These paintings are part of the aforementioned art collection of the Universitat de València, and are housed at the Faculty of Medicine. In this study, the use of MTP, IRR and hyperspectral imaging techniques were combined with the analysis of the pictorial surface using a portable optical microscope and a portable X‐ray fluorescence. The results obtained indicate that Manuel Moreno Gimeno developed a landscape painting technique that was very close to that of other Valencian painters of the early 20th century. The handling of light and color was achieved using a rich color palette that included numerous contemporary innovative pigment such as chrome or cadmium.