bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multisummability for generalized power series
Authors: Rolin Jean-Philippe , Servi Tamara , Speissegger Patrick 
Published: February 2023

AbstractWe develop multisummability, in the positive real direction, for generalized power series with natural support, and we prove o-minimality of the expansion of the real field by all multisums of these series. This resulting structure expands both
$\mathbb {R}_{\mathcal {G}}$
and the reduct of
$\mathbb {R}_{\text {an}^*}$
generated by all convergent generalized power series with natural support; in particular, its expansion by the exponential function defines both the gamma function on
$(0,\infty )$
and the zeta function on
$(1,\infty )$
.
Hartebeesthoek Radio Astronomy Observatory (HartRAO) antenna axis offset determined by geodetic VLBI analysis and ground survey
Authors: Nickola Marisa , Krásná Hana , Combrinck Ludwig , Böhm Johannes , De Witt Aletha 
Published: February 2023

In the Very Long Baseline Interferometry (VLBI) space geodetic technique, various station-specific error sources corrupt the observable VLBI delay. An antenna axis offset (AO) model is applied in the VLBI data analysis for antennas with non-intersecting rotational axes, such as the 26-m and 15-m antennas for the Hartebeesthoek Radio Astronomy Observatory (HartRAO). The a priori AO values recommended by the International VLBI Service for Geodesy and Astrometry (IVS) for use in geodetic VLBI data analysis are taken, where possible, from values measured in ground surveys. The a priori AO values used for the HartRAO antennas in geodetic VLBI analysis have been identified as possible sources of error. The a priori AO value of 6695.3 mm for the 26-m antenna originates from a 2003 co-locational ground survey, conducted before a major bearing repair in 2008, which could have changed the AO. The a priori AO value of 1495.0 mm for the 15-m antenna was determined in 2007 in only a preliminary GPS survey. In this study, the respective AO values of the HartRAO 26-m and 15-m antennas were estimated from a VLBI analysis using the Vienna VLBI and Satellite Software (VieVS) and compared with measurements from co-locational ground surveys. It was found that the VLBI estimated values do not agree within the formal margins of error with the ground survey values, in that they differ by up to eight millimetres (8 mm) for the 26-m antenna and up to five millimetres (5 mm) for the 15-m antenna. As the ground survey values are considered to be more accurate than the VLBI estimated values, a further investigation of the site-specific error sources that may be contaminating the accuracy of VLBI results is required.
Riccardin D, a drug candidate, inhibits gastric cancer progression by targeting RAD54L
Authors: Pan Qi , Zhu Weimin , Xiang Pei 
Published: February 2023

Purpose: To investigate the beneficial function of RAD54L in gastric cancer.
Methods: Batch correction, metaboanalyst, volcano plot and heatmap were used for analyzing different expression genes. Metascape and strings were used for functional enrichment and protein-protein interaction network analysis, respectively. Expression of RAD54L was analyzed using online platform-timer, ualcan and GEPIA. Correlation between RAD54L and poor prognosis was analyzed using Kaplan-Meier curve. Expression of RAD54L was evaluated by Real Time-quantitative PCR and western blotting, while cell proliferation, cell apoptosis and cell cycle were determined by CCK8 and flow cytometry, respectively.
Results: A total of 57 upregulated DEGs and 33 downregulated DEGs were involved in gastric cancer. Among these, RAD54L was a hub gene which is highly expressed, and is related to poor survival in gastric cancer. Moreover, knockdown of RAD54L inhibited cell viability and facilitated cell apoptosis in gastric cancer cells (p < 0.05). On the other hand, overexpression of RAD54L promoted cell proliferation and reduced cell apoptosis in gastric cancer (p < 0.05). In addition, RAD54L positively regulated cell cycle in gastric cancer cell lines. Furthermore, riccardin D negatively regulated cell cycle in gastric cancer cell lines by targeting RAD54L.
Conclusion: Riccardin DRAD54L is a potential drug for the treatment of gastric cancer. However, developmental work, including in vivo studies, are required to ascertain this.
Toxicological testing of Fuganlin Oral Liquid on young Sprague Dawley rats
Authors: Guo Jianmin , Huang Yuankeng , Lei Xialing , Deng Yinghua , Li Xiaoying , Zhang Wenqiang , Chen Wenpei , Meng Feibiao , Yang Wei 
Published: February 2023

Purpose: To further evaluate the safety of Fuganlin Oral Liquid (FGLOL) for clinical application by conducting toxicological tests in young rats.
Methods: Based on the clinical dose for infants aged less than 1 year, 4-day-old Sprague-Dawley (SD) rats were orally administered FGLOL3.88, 11.64 and 38.75 g crude drug/kg for 18 days, followed by a 3-week withdrawal. This was followed by evaluating the effect of FGLOL on various growth and development indicators, nerve reflex function and spontaneous behavior of the rats. Based on the clinical dose for children aged 1 - 6 years, 15-day-old rats were orally administered FGLOL3.88, 11.64 and 38.75 g crude drug/kg for 31 days, followed by a 3-week withdrawal in order to evaluate the impact of the FGLOL on the development of reproductive organs and nervous systems in young rats. The effects of FGLOL on the safety of young rats were judged based on ophthalmic examination, physical examination, spontaneous behavior and other developmental effects.
Results: FGLOL did not cause animal death, and no significant toxicological changes were observed in the body weight, growth and development, and behavior of the young rats (p < 0.05). No observed adverse effect level (NOAEL) even after administering the higher dose at each stage. However, the results at each stage showed that oral administration of a large amount of FGLOL had a greater effect on normal food consumption of the rats (p < 0.05).
Conclusion: The findings indicate that Fuganlin Oral Liquid, a traditional Chinese medicine formulation, is safe in rats. However, clinical trials are required to acertain its safety in humans.
Efficacy of combined application of traditional Chinese medicine foot bath and mild moxibustion in the treatment o f limb pain in diabetic peripheral neuropathy patients
Authors: Wang Jiawei , Mao Yuanyuan , Jiang Chunyan , He Mengqi , Tan Qingying , Zheng Wei 
Published: February 2023

Purpose: To determine the efficacy of the combination of traditional Chinese medicine (TCM) foot bath and mild moxibustion in the treatment of limb pain in patients with diabetic peripheral neuropathy (DPN).
Methods: A total of 120 patients with symptoms of DPN-induced pain who were hospitalized at the Department of Endocrinology in the 903rd Hospital of PLA, from January 2020 to June 2021, were included in this study. They were randomly assigned to a study group and a control group, with 60 patients in each group. Patients in both groups received conventional treatments and nursing care, while those in study group were additionally treated with a combination of TCM foot bath and mild moxibustion. Treatment efficacy in the patients was evaluated using Short-Form McGill Pain Questionnaire (SF-MPQ), pain rating index (PRI), visual analogue scale (VAS), TCM symptom score (TCMSS), and Toronto Clinical Scoring System (TCSS).
Results: Compared with control group, there were significant improvements in pain-related scores, namely, SF-MPQ, (p ˂ 0.05); PRI, (p < 0.01); VAS, (p < 0.05); as well as overall efficacy (p < 0.05). Similar improvements were also observed with regard to TCMSS (p < 0.001) and TCSS (p < 0.001) in the study group. However, there were no significant changes in Adjusted Diabetes Quality of Life (A-DQOL) score and blood glucose control in both groups.
Conclusion: Relative to the conventional treatment for DPN, limb pain and disease score of patients are significantly reduced by the combination of TCM foot bath and mild moxibustion treatments. Further clinical trials would be required prior to application in clinical practice.
Galangin protects gastric mucosa from indomethacin induced injury via scavenging ROS and inhibition of PKC, Akt, and NF κB protein expressions
Authors: Gong Jingwen , Xie Yu , Tan Yinfen , Li Hailong , Zhang Junqing 
Published: February 2023

Purpose: To investigate the mechanism of action of galangin (GAL) against indomethacin (Indo)-induced gastric injury.
Methods: Ten micromolar GAL with 2 mM Indo or 0.5 mM L-NAME or 2 mM propargylglycine were co-administered to human gastric mucosal epithelial cells GES-1 for 24 h. Cell viability assay and reactive oxygen species (ROS) test were conducted with commercial kits. Protein expressions of constitutive and inducible nitric oxide synthase (cNOS and iNOS, respectively), and cystathionine-γ-lyase (CSE) in GSE-1 cells were investigated by western blot. After 100 - 300 mg/kg, GAL was daily administered to rats for 5 days, and 30 mg/kg Indo was administered to induce gastric injury. Protein expressions of endothelial NOS (eNOS), iNOS, CSE, nuclear factor (NF)-κB, PKC, Akt, phospho-eNOS (Ser-1177), and phospho-eNOS (Thr-495) were investigated by western blot.
Results: Galangin ameliorated the proliferative inhibitions of Indo, propargylglycine, and L-NAME on GSE-1 cells (p < 0.05), rapidly scavenged ROS, and increased cNOS protein expressions (p < 0.05). Galangin (300 mg/kg) inhibited protein expressions of iNOS (p < 0.01), NF-κB, Akt, and PKC (p < 0.05), inhibited the Ser-1177 and Thr 495 phosphorylation of eNOS, elevated eNOS and CSE protein expressions (p < 0.001).
Conclusion: Galangin protects gastric mucosa from Indo by scavenging ROS and inhibiting protein expressions of Akt and PKC. The inhibition leads to Ser-1177 and Thr 495 dephosphorylation of eNOS, thereby prolonging eNOS activity. Besides, GAL inhibits iNOS-produced NO by inhibiting NF-κB to ameliorate the inflammatory reaction induced by Indo.
TRIM8 regulates contrast induced renal cell injury via the TLR4/MyD88/ NF kB pathway
Authors: Li Weigang , Su Lili , Zhang Jian 
Published: February 2023

Purpose: To investigate the effect of tripartite motif-containing protein 8 (TRIM8) on contrast media-induced injury on kidneys in mice and on human renal tubular epithelial cells.
Methods: Contrast media-induced nephropathy (CIN) model was constructed by injecting meglumine diatrizoate in mice. Small interference technology was used to knock down the expression of TRIM8 in HK-2 cells, while quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) were used to determine the expression levels of the inflammatory factors: TNF-α, TGF-β1, IL-1β, and IL-4. Cell counting kit-8 (CCK-8) assay was employed to determine the cell viability of each group, and TUNEL staining applied to detect apoptosis morphology using a fluorescence microscope. Flow-type Annexin V-FITC/PI double staining and Caspase-3 activity colorimetry were used to observe the changes in apoptosis. Expression of apoptosis factors, including Bax, Caspase3, Caspase9, and anti-apoptotic factor Bcl-2, was determined by qRT-PCR, while expressions of the TLR4/MyD88/NF-kB pathway were determined using Western blot and qRT-PCR.
Results: In CIN group, the kidney tissues significantly expressed IL-1β and Caspase3, while the contents of BUN, SCr, and UP all increased (p < 0.05). At the same time, expression of TRIM8 in the kidney tissues was up-regulated. After knocking down TRIM8, HK-2 cells inhibited the contrast agent-induced apoptosis and inflammation and as well as TLR4/MyD88/NF-kB pathway (p < 0.05).
Conclusion: TRIM8 regulates contrast-induced renal cell damage via TLR4/MyD88/NF-KB pathway. The results of the current study may provide new insights for the development of new treatment strategies for CIN.
MiR 378a/FSCN1 regulatory axis inhibits tumor stemness and increases the cytotoxicity of chemotherapeutic drugs in colorectal cancer cells
Authors: Zhang Taizhe , Du Jie , Li Sandang , Zheng Chuanming , Wang Zhenjie , Xie Fuchen 
Published: February 2023

Purpose: To evaluate the effect of miR-378a/FSCN1 axis on tumor stemness and aerobic glycolysis in colorectal cancer cells (CRC).
Methods: Abnormal expressions of miR-378a and FSCN1 in CRC tissues were analyzed through TCGA database. Cell viability and apoptosis were determined using 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT) assay and flow cytometry, respectively, while expression of miR-378a was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Furthermore, Western blotting assay was used to assess protein expressions. The miR-378a target was evaluated using ENCORI and confirmed by luciferase assay. Aerobic glycolysis was evaluated by determining glucose uptake, lactate production and lactate dehydrogenase (LDH) activity.
Results: Downregulation of miR-378a and upregulation of FSCN1 were observed in both CRC tissues and cell lines (p < 0.05). Overexpression of miR-378a and repression of FSCN1 reduced cell viability and tumor sphere formation, and induced cell apoptosis. Protein expression of SOX2, KLF4, Bmi1 and Oct-4 were downregulated by either the overexpression of miR-378a or repression of FSCN1 (p < 0.01). Glucose uptake, lactate production and LDH activity were inhibited by either overexpression of miR-378a or repression of FSCN1, while cytotoxicity of Dox and 5-Fu was increased by upregulation of miR-378a or downregulation of FSCN1 (p < 0.05). The predictive results of ENCORI demonstrated that FSCN1 was the direct target of miR-378a, and this was confirmed by luciferase assay results (p < 0.005). All the effects of miR-378a in CRC were reversed by overexpression of FSCN1 (p < 0.05).
Conclusion: This study has shown that miR-378a suppresses tumor stemness and increases the cytotoxicity of chemotherapeutic drugs by directly targeting FSCN1, resulting in the prevention of CRC tumorigenesis. Thus, these findings suggest a new approach to the chemotherapeutic management of CRC.
Knockdown of PLAGL2 in hibits oral squamous cell carcinoma cell growth and cisplatin resistance via ZEB1/PD L1 pathway
Authors: Zhang Changqing , Ye Fei 
Published: February 2023

Purpose: To investigate the effects of pleomorphic adenoma gene like-2 (PLAGL2) on oral squamous cell carcinoma (OSCC).
Methods: The effects of PLAGL2 on OSCC (CAL-27 and HSC-3) were conducted with loss- and gain-functional assays. Cell proliferation was determined by Cell Counting Kit-8 (CCK8) and colony formation assays. Cell metastasis was assessed by Transwell and wound healing assays. Cell apoptosis of cisplatin-resistant OSCC was evaluated by flow cytometry.
Results: PLAGL2 expression was significantly elevated in OSCC (p < 0.001), while silencing of PLAGL2 significantly reduced cell proliferation and metastasis of OSCC (p < 0.001). However, overexpression of PLAGL2 promoted OSCC progression through increase in cell proliferation, invasion, and migration. Knockdown of PLAGL2 promoted cell apoptosis of -resistant OSCC, but significantly downregulated protein expression of programmed cell death ligand 1(PD-L1) and zinc finger E-box-binding homeobox 1 (ZEB1) in OSCC (p < 0.01). Moreover, loss of ZEB1 attenuated the PLAGL2 overexpression-induced increase in ZEB1 and PD-L1. Loss of PLAGL2 also reduced in vivo tumor growth of OSCC via regulation of cluster of differentiation 4 protein (CD4) and CD8.
Conclusion: Knockdown of PLAGL2 exerts anti-tumor effects, improves cisplatin resistance, and enhances anti-tumor immunity in OSCC through suppression of ZEB1/PD-L1 pathway. Thus, PLAGL2 might be a potential therapeutic target for the treatment of OSCC.
Relationship between Press Mentions and Brand Awareness
Authors: Babich Nikolay S. , Senchilo Bogdan S. 
Published: February 2023

The article is devoted to the study of the process of brand awareness formation under the influence of mass media. Knowing the parameters of this process allows us to answer the question of how many times a person must meet a brand in the media environment in order to remember it, and what extent of brand mentioning in the media must be achieved in order to get a certain level of its popularity. Two aspects of awareness are singled out: recall (knowledge without prompting) and recognition (knowledge with prompting). An empirical study was carried out, which made it possible to isolate and measure, on a sufficient level of accuracy, the influence of the Russian central press on the brand awareness of more than 20 sociological companies in Russia over a period of 15 years. It showed that the presence of a brand in the press is significant, and it affects linearly both forms of awareness – recall and recognition. A strong linear relationship allows us to calculate the effective frequency of introductions and to build a predictive model for the formation of brand awareness under the influence of the media, as well as, using plausible assumptions, to estimate the effective frequency of contacts.
Videogames as a Digital Attempt to Touch the Mythological
Authors: Rezvushkina Sofya A. 
Published: February 2023

The article deals with the analysis of video games and the use of VR technologies in the gaming sphere. The trend towards increasing gamification of modern man's being is examined and problematized. The main question raised by the author is what is the actual status of video games in the existence of modern man.
The aim of the research is to study the ontoanthropology of video games, and VR games in particular, and search for their correlates with archaic practices. This, in turn, led to the consideration of the ontoanthropology of the virtual and the ontoanthropology of the game as its variety.
The author comes to a conclusion that video games are a substitute for initiation which is most fully and safely performed by means of immersive equipment and taking rite-ritual activity into virtual reality. The results of the study can be used for an expert assessment of video games, identifying the prospects for their implementation in pedagogical, psychological or other consulting activities aimed at achieving a sense of inner transformation of the person in the direction of greater completeness and authenticity of existential experience. The findings can form the basis for philosophical conceptualization of modern mechanisms of digital identity formation and contribute to the growth of socio-humanitarian reflection on the problem of human self-identification and methods of achieving a sense of ontological fundamentality and wholeness of being in a virtual reality.
Performance Analysis of Road and Bridge Planning Consultants in Highway Work in Banjarbakula
Authors: Ramadani Wahid , Prasetia Irfan 
Published: February 2023

The results of planning often find errors in road handling methods and volume inaccuracies between planning and field conditions. This study aims to analyze the performance of planning consultants on indicators of planning documents, indicators of planning performance, and indicators of understanding of planning references. To determine the level of performance satisfaction used CSI method. As for knowing the performance that must be improved or less satisfactory, the IPA method is used.
From the research results obtained based on the CSI method, Planning Document Indicators got 61.51% (Quite Satisfied), Planning Performance Indicators got 70.01% (Satisfied), and Indicators of Understanding of Planning References got 62.63% (Quite Satisfied). This study succeeded in identifying five factors that affect the performance of the planning consultant and need to be improved, namely 1) Conformity between the drawing documents, RKS, and Engineer Estimate, 2) The suitability of the type of personnel costs with project needs, 3) The suitability of the types of non-personnel costs with project needs, 4) Accuracy of data collection, and 5) The suitability of the method of calculating personnel costs with planning guidelines.
The first strategy of the consultant is to commit to using competent personnel according to the qualifications listed. The second strategy of the consultant is to review the planned site carefully. Moreover, the last strategy is for consultants to work more optimally and effectively in construction projects.
Organized Corporate Crimes using UNCITRAL Arbitration Framework Development for EPC Disclosure concerning Epistemic Corruption and Pharmaceutical Fraud of Off-label Medicines as Health Regulation and Policy
Authors: Llarena Zharama 
Published: February 2023

Purpose: Corporate Governance is a conceptual framework of business designs intended to illustrate the various activities of a company towards fulfilling its profit goals as private stakeholder and contributing to public interests for social obligation of sustainable development. Disclosure of corporate social responsibility is the central mechanism of corporate governance.
Methodology: Based on stakeholder theory, corporate governance strongly influences corporate social responsibility disclosure to enhance the relationship of stakeholders and its business community.
Findings: Tax aggressiveness is utilized by board director and its members to lessen tax contribution which is contrary to the government sector goals of maximizing tax impositions for public welfare and safety. Unlawful behavior on tax aggressiveness is known as tax evasion while tax avoidance is not a violation and serves as a loophole to the taxation system, although corporate fraud is apparent in off-label medicines. UNCITRAL model law is a legal arbitration concept of making “commercial” expand to other comparable jurisdiction of international trade. The European Patent Commission is the legal authority that delineates medical policies from patented products.
Unique Contribution to Theory, Practice and Policy: This paper aims to develop arbitration framework based on stakeholder theory of corporate governance to separate tax evasion from tax avoidance as organized crime sourcing treatment of policies and engineer tax planning to divide intellectual property of product design with corporate fraud concerning off-label medicines. Therefore, tax evasion and corporate fraud are business crimes in pharmaceutical industries needed to be clearly managed by institutional healthcare companies for promoting economic success.
Entre dentes, cartas e afeto, a correspondência de Otto para Josué
Authors: Rettenmaier Miguel , Santin Bruna 
Published: February 2023

A divulgação de correspondência entre escritores possui as suas justificativas afiançadas, na grande maioria dos casos, pela amizade que duas personalidades de um mesmo círculo literário cultivaram. Sendo regado por tal sentimento, a quantidade de testemunhos sobre o cotidiano, vida e obra renasce através da leitura das cartas particulares e afetivas de autores. Para tanto, este trabalho pretende averiguar discursos no íntimo epistolar de dois importantes escritores – Josué Guimarães e Otto Lara Resende – os quais trocaram correspondências, algumas das quais estão sob guarda do ALJOG/UPF, na Universidade de Passo Fundo. Com o objetivo da verificação da memória no diálogo íntimo missivista dos dois autores, algumas cartas serão remontadas neste trabalho com o intuito de evidenciar a amizade entre ambos, a qual deixa transparecer processos importantes de leitura e apoio, principalmente pela voz de Otto. Amparado por Santiago (2006), Diaz (2016) e Bouzinac (2016), este trabalho resgatará a voz privada e desconhecida até então na epistolografia daqueles cuja importância literária jamais será esquecida.