bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of mitral valve haemodynamic parameters obtained by intraprocedural echocardiography in transcatheter edge-to-edge repair
Authors: Shechter Alon , Natanzon Sharon Shalom , Koseki Keita , Kaewkes Danon , Lee Mirae , Koren Ofir , Patel Vivek , Skaf Sabah , Chakravarty Tarun , Makar Moody , Makkar Raj R , Siegel Robert J 
Published: February 2023

Abstract

Aims
To assess whether intraprocedural transesophageal echocardiographic (TEE)-derived haemodynamic parameters predict outcomes in patients undergoing transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR).

Methods and results
This is a single-centre, retrospective analysis encompassing 458 (IQR, 104–1035) days of follow-up after 926 consecutive patients [481 (52%) with functional MR] referred to an isolated mitral TEER between 2013 and 2020. Cases without actual clip deployment, or in whom prior mitral procedures had taken place, were excluded. The primary outcome was the combined rate of all-cause mortality or heart failure (HF) hospitalizations. Secondary endpoints included single components of the primary outcome, as well as MR severity at one month and one year following the procedure. A multivariable analysis identified two intraprocedural echocardiographic observations made after clip deployment as independent predictors of the primary outcome: an above mild MR (HR for whole study period 1.49, 95% CI 1.05–2.13, P = 0.026) and a 100% or more increase from baseline in the transmitral mean pressure gradient (TMPG) (HR for whole study period 1.32, 95% CI 1.01–1.72, P = 0.039). Also, MR grade of above mild and the absence of a normal pulmonary venous flow pattern (PVFP) bilaterally were associated with an increased risk for HF hospitalizations and greater-than-mild 1-month MR. No prognostic role was demonstrated for the change in MR severity, the absolute TMPG, or the mere improvement in PVFP.

Conclusion
Immediate post-TEER MR severity and the relative change in TMPG are predictive of clinical and echocardiographic outcomes following the procedure.
Immunodeficiency is prevalent in congenital heart disease and associated with increased risk of emergency admissions and death
Authors: Diller Gerhard-Paul , Lammers Astrid Elisabeth , Fischer Alicia , Orwat Stefan , Nienhaus Klara , Schmidt Renate , Radke Robert M , De-Torres-Alba Fernando , Kaleschke Gerrit , Marschall Ursula , Bauer Ulrike M , Roth Johannes , Gerß Joachim , Bormann Eike , Baumgartner Helmut 
Published: February 2023

Abstract

Aims
To provide population-based data on the prevalence and clinical significance of immune deficiency syndromes (IDS) associated with congenital heart disease (CHD).

Methods and results
Utilizing administrative German Health System data the prevalence of increased susceptibility to infection (ISI) or confirmed IDS was assessed in CHD patients and compared with an age-matched non-congenital control group. Furthermore, the prognostic significance of IDS was assessed using all-cause mortality and freedom from emergency hospital admission. A total of 54 449 CHD patients were included. Of these 14 998 (27.5%) had ISI and 3034 (5.6%) had a documented IDS (compared with 2.9% of the age-matched general population). During an observation period of 394 289 patient-years, 3824 CHD patients died, and 31 017 patients experienced a combined event of all-cause mortality or emergency admission. On multivariable Cox proportional-hazard analysis, the presence of ISI [hazard ratio (HR): 2.14, P &lt; 0.001] or documented IDS (HR: 1.77, P = 0.035) emerged as independent predictors of all-cause mortality. In addition, ISI and confirmed IDS were associated with a significantly higher risk of emergency hospital admission (P = 0.01 for both on competing risk analysis) during follow-up.

Conclusion
Limited immune competence is common in CHD patients and associated with an increased risk of morbidity and mortality. This highlights the need for structured IDS screening and collaboration with immunology specialists as immunodeficiency may be amenable to specific therapy. Furthermore, studies are required to assess whether IDS patients might benefit from intensified antibiotic shielding or tailored prophylaxis.
A stepwise external cardioversion protocol for atrial fibrillation to maximize acute success rate
Authors: Darrat Yousef , Leung Steve , Elayi Liliane , Parrott Kevin , Ogunbayo Gbolahan , Kotter John , Sorrell Vincent , Gupta Vedant , Anaya Paul , Morales Gustavo , Catanzarro John , Delisle Brian , Elayi Claude S 
Published: February 2023

AbstractAimsCardioversion is a very commonly performed procedure for persistent atrial fibrillation (AF). However, there is no well-defined protocol to address failed external electrical direct current cardioversion. The aim of the study is to test the efficacy of a pre-defined stepwise cardioversion protocol for patients with persistent AF of ≤12 months. Success was the achievement of sinus rhythm.Methods and resultsThe study population included patients with persistent AF of ≤12 months duration requiring rhythm management. Patients were offered cardioversion using a pre-defined stepwise protocol using different electrode placement locations, applying compression at end of expiration, and higher energy delivered simultaneously through two defibrillators. : A total of 414 patients were included in the study, of which 362 (87.4%) required a single successful cardioversion. The remaining 52 (12.5%) patients required additional cardioversion attempts using the stepwise cardioversion protocol with an overall success rate of 99.3%. Two simultaneous defibrillators were required in 14 patients (3.4%). Patients with multiple cardioversions (13.5%) experienced more local skin irritation and pain compared with patients with single cardioversion (13.5% vs. 3.5%, P = 0.004). The predictor for the need for multiple cardioversion attempts is high body mass index, while high transthoracic impedance is associated with failed cardioversion. No major complications were observed during the study.ConclusionThe stepwise cardioversion protocol has a high success rate of &gt;99% and can be safely performed in outpatient or inpatient settings.
Facilitating Volunteer Engagement Among Older Adults in Social Services: A Case Study of an Innovative Timebank Program in a Chinese Society
Authors: Lu Shiyu , Chui Cheryl , Lum Terry 
Published: February 2023

Abstract

Background and Objectives
Exploring the roles of older adults as volunteers in social care settings has attracted wide attention to facilitate healthy aging and tackle care workforce constraints. However, there is little knowledge of the mechanism of engaging older adults as volunteers in the social care sector.

Research Design and Methods
The study applies a case study to describe the features of an innovative timebank project, Good Hands, and explore the underlying mechanism of engaging older adults as volunteers in the social care sector. Three focus groups were conducted with 12 older adult volunteers and 6 advisory group members. Thematic analysis was applied to code and analyze the content of the focus group interviews.

Results
Three emergent themes were identified as critical components: strong cross-sector collaboration, meaningfulness in voluntary work comprising 4 subthemes (including capacity optimization, care capacity enhancement, cultivating belonging, and value recognition), and a coproducing environment.

Discussion and Implications
Volunteer engagement of older adults in the provision of welfare for community-based care for frail peers is discussed, and practice implications are presented.
Inference of velocity structures of oceanic crust and upper mantle from surface waveform fitting
Authors: Nagai Haruka , Takeuchi Nozomu , Kawakatsu Hitoshi , Shiobara Hajime , Isse Takehi , Sugioka Hiroko , Ito Aki , Utada Hisashi 
Published: February 2023

SUMMARYInversion for seismological structures of the oceanic lithosphere–asthenosphere system is important to understand the mechanisms of plate tectonics. Previous models of the oceanic upper mantle have been primarily obtained via global tomography using surface waveforms. However, besides scarcity of waveform data in the oceanic regions, difficulties in fitting phases for shorter-period components in the previous global tomography have yielded resultant models that possess poor resolutions above $\sim \, 50$ km depth. Recent developments of broad-band ocean-bottom seismometer (BBOBS) arrays provide larger amount of seismic data with epicentral distances of &lt;20°. In this study, we develop an appropriate method to fully utilize the information contained in the shorter-period components of BBOBS arrays. We first fit the envelopes without phase information to analyse the shorter-period components (8–60 s) which are generally unavailable in the conventional phase fitting. We then use the resultant model as our initial model for waveform inversion of the longer periods (12.5–200 s) to fit the phase, which allows us to infer a continuous structure model from the crust to the asthenosphere. We demonstrate the validity of this combined envelope-fitting and waveform inversion method by analysing the waveform data from a BBOBS array that was deployed in the Northwestern Pacific and has recorded events in the vicinity of the Japan Trench to obtain the average velocity structure between the event and station arrays. We independently resolve the crustal compressional and shear wave velocities, and thickness by analysing the envelopes, which minimizes biases in the subsequent waveform inversion. We also find that the waveform inversion improves the resolution in the asthenosphere. Our results suggest that further extension of this method should improve our knowledge of the oceanic lithosphere–asthenosphere system.
Lowering the vertical component seismic noise-floor in the normal-mode band by frequency-dependent air-pressure corrections
Authors: Lepage Thea , Forbriger Thomas , Zürn Walter , Rietbrock Andreas 
Published: February 2023

SUMMARY
Contrary to popular belief in seismology, the vertical component seismic background level of Earth’s body in the normal-mode band is lower than current low-noise models would indicate. With a correction of atmospherically induced disturbances the low-noise level of the vertical component of the STS-1 at Black Forest Observatory (BFO) is reduced below the Peterson low noise model (NLNM). We demonstrate this with a moving window analysis (MWA) of 10 yr of data in the normal-mode band between 0.2 and 2 mHz. The 5th percentile low-noise level for the data initially is at the level of the NLNM. We lower this by 8 dB at the frequency of 0S2 (0.31 mHz) by partially correcting the seismometer recording in the time domain for disturbances caused by mass fluctuations in the atmosphere. The disturbances are estimated by the frequency dependent ‘improved Bouguer plate model’ (IBPM, defined by asymptotic admittance αDC and notch-frequency fn) from a recording of local air-pressure. In more than 90 per cent of the time windows of the MWA the signal level is lowered when using a priori set IBPM-parameters ($\alpha _{\text{DC}}= -3.5\, {\rm nm\, s}^{-2}\, {\rm hPa}^{-1}$, $f_{\text{n}}=2.25\, {\rm mHz}$). In 50 per cent of the time windows the background level at the frequency of 0S2 is reduced by at least 6 dB. With a priori set IBPM-parameters the level of the 1st percentile is lowered by up to 16 dB for windows of $1\, {\rm d}$ length and by 13 dB for windows of $7\, {\rm d}$ length. Overall, there is little additional benefit from optimizing the IBPM-parameters per time window. If optimized per time window, the parameters show a slight annual variation which apparently compensates for systematic deviations of the dynamics of the atmosphere from the simple considerations of the IBPM-model. By application of the correction procedure and with seismic sensors of sufficiently low self-noise, the range of observations for signals from Earth’s body can be extended to below current low-noise models at frequencies below 2 mHz.
3-D Bayesian variational full waveform inversion
Authors: Zhang Xin , Lomas Angus , Zhou Muhong , Zheng York , Curtis Andrew 
Published: February 2023

SUMMARYSeismic full-waveform inversion (FWI) provides high resolution images of the subsurface by exploiting information in the recorded seismic waveforms. This is achieved by solving a highly non-linear and non-unique inverse problem. Bayesian inference is therefore used to quantify uncertainties in the solution. Variational inference is a method that provides probabilistic, Bayesian solutions efficiently using optimization. The method has been applied to 2-D FWI problems to produce full Bayesian posterior distributions. However, due to higher dimensionality and more expensive computational cost, the performance of the method in 3-D FWI problems remains unknown. We apply three variational inference methods to 3-D FWI and analyse their performance. Specifically, we apply automatic differential variational inference (ADVI), Stein variational gradient descent (SVGD) and stochastic SVGD (sSVGD), to a 3-D FWI problem and compare their results and computational cost. The results show that ADVI is the most computationally efficient method but systematically underestimates the uncertainty. The method can therefore be used to provide relatively rapid but approximate insights into the subsurface together with a lower bound estimate of the uncertainty. SVGD demands the highest computational cost, and still produces biased results. In contrast, by including a randomized term in the SVGD dynamics, sSVGD becomes a Markov chain Monte Carlo method and provides the most accurate results at intermediate computational cost. We thus conclude that 3-D variational FWI is practically applicable, at least in small problems, and can be used to image the Earth’s interior and to provide reasonable uncertainty estimates on those images.
Schumpeter’s insights for monetary macroeconomics and the theory of financial crises
Authors: Bofinger Peter , Geißendörfer Lisa , Haas Thomas , Mayer Fabian 
Published: February 2023

AbstractThe purpose of this paper is to show that Schumpeter can offer important insights for macroeconomic theory today. This applies especially to his distinction between a “real analysis” and a “monetary analysis,” as he calls it, and its implications for monetary macroeconomics, especially the theories of financial crises at the national and the global levels. The main problem of the “real analysis” is the identity of the financial sphere with the real sphere. The consequence of this narrow view is the inability to understand the dynamics of a monetary economy, which is the main cause for financial crises. The flaws of the real analysis manifest themselves also at the global level. The Feldstein–Horioka puzzle and the Lucas paradox are obvious “anomalies” of this paradigm. Models based on the real analysis are unable to explain the extent and even direction of international capital flows. Thus, the economics profession was unable to see the risks that were accumulating in the international financial system before the outbreak of the Great Financial Crisis.
Botanical Authentication Using One-Class Modeling
Authors: Harnly James 
Published: February 2023

Abstract

Background
Authentication methods are necessary to guarantee the integrity of botanical supplements and their ingredients. In 2012, AOAC International published “Guidelines for Validation of Botanical Identification Methods” however these guidelines proved rather cumbersome.

Objective
Develop a simpler method for validatation based on one-class modeling that only considers authentic materials.

Methods
One-class modeling uses chemometric analysis based on soft independent modeling of class analogy and the specific pre-processing steps of sample vector normalization and autoscaling.

Results
Any unknown sample can be judged authentic or adulterated based on its agreement with the profile of the authentic samples. The sensitivity and accuracy of one-class modeling is improved using sample vector normalization and autoscaling. The limit of detection for any variable is statistically predictable.

Conclusion
One-class modeling offers a simple approach to authentication and is applicable to any non-targeted analytical method. Only the characteristics of the authentic samples are necessary and no specification of an adulterant is necessary.

Highlights
One-class modeling offers a simple approach to authentication and is easily implemented using any chemometrics platform.
Total fishmeal replacement by defattedTenebrio molitorlarvae meal induces alterations in intermediary metabolism of European sea bass (Dicentrarchus labrax)
Authors: Basto Ana , Valente Luisa M P , Sousa Vera , Conde-Sieira Marta , Soengas José L 
Published: February 2023

AbstractThe replacement of fishmeal (FM) by insect meal (IM) in aquafeed formulation has been thoroughly studied lately, but little is known about their impact on nutrient metabolism of fish. This study evaluated the impact not only of partial but also total FM replacement by IM on intermediary metabolism of European sea bass (Dicentrarchus labrax). A fishmeal-based diet was used as a control (CTRL) and two other diets were formulated to include 20% and 40% of defatted Tenebrio molitor larvae meal (dTM), replacing 50% (TM50) and 100% (TM100) of fishmeal (FM), respectively. After a 16-week feeding trial, a multidisciplinary approach including assessment of histological, biochemical, molecular, and enzymatic parameters was adopted to investigate hepatic and plasmatic responses to the different dietary formulations. The results obtained demonstrated that dTM can be successfully used to replace 50% of FM in diets for European sea bass, without adversely affecting liver health or intermediary metabolism of nutrients. As for TM100, although no signs of steatosis were observed in the liver, the activity of glycolytic and lipogenic genes and enzymes increased when compared to CTRL diet (P &lt; 0.05), resulting in higher levels of plasmatic non-esterified fatty acids and triacylglycerides (P &lt; 0.05), which in the long-term may compromise fish health, thus precluding such a high degree of substitution for use in practical diets for European sea bass.
Effect of forage types differing in undigested neutral detergent fiber concentration and forage inclusion rate on reticulo-ruminal motility and fermentation, total tract barrier function, and blood metabolites of finishing beef heifers
Authors: Pereira Murillo Ceola Stefano , Yang Wenzhu Z , Beauchemin Karen A , McAllister Timothy A , Wood Katharine M , Penner Gregory B 
Published: February 2023

AbstractThis study evaluated the effects of forages (BarS vs. STR) that differ in the uNDF concentration and FI rate on ruminal fermentation, total tract barrier function, reticulo-ruminal motility, and blood metabolites of beef heifers. Six ruminally cannulated Hereford × Simmental heifers (699 ± 69.1 kg BW) were used in a 6 × 6 Latin square (26 d periods) with a 2 × 3 factorial treatment arrangement. However, 1 heifer was removed from the study after period 2 due to health problems unrelated to treatment, resulting in an incomplete 6 × 6 Latin square design. Barley grain-based diets were formulated using BarS or wheat STR to alter uNDF (7.1% vs. 8.5% DM) with FI rates of 5%, 10%, or 15% of DM. There were limited interactions between the forage type and FI. DM intake was not affected (P ≥ 0.10) by forage type or FI. Use of STR vs. BarS increased uNDF intake (P &lt; 0.001). Increasing FI increased (P &lt; 0.001) uNDF intake for those fed 15% forage. Ruminal pH was not affected (P ≥ 0.10) by forage type; however, cattle fed 5% FI had lesser (P = 0.017) mean ruminal pH and maximum pH (P = 0.018) than those fed 10% and 15% of forage. The total SCFA concentration was not affected by forage type (P = 0.84) but cattle fed the 5% FI rate had lesser (P &lt; 0.001) molar proportion of acetate when compared with cattle fed 10% and 15% forage. Increasing the FI rate decreased the molar proportion of propionate (P &lt; 0.001). Feeding STR relative to BarS decreased (P = 0.041) the reticulo-ruminal contraction duration. In contrast, cattle fed the 10% and 15% FI rates had a greater (P = 0.028) contraction frequency with lower (P = 0.048) contraction area than those fed 5% forage. Plasma glucose, serum insulin, and serum amyloid A were not affected by forage type or FI rate (P ≥ 0.10). Cattle fed 15% forage had lesser (P = 0.040) concentration of serum haptoglobin when compared with cattle fed 5% or 10% forage. In conclusion, forage type used to affect the dietary uNDF concentration, and FI rate act independently suggesting that the provision of STR to increase uNDF reduces reticulo-ruminal contraction duration and total tract permeability but may not affect ruminal pH. Increasing the FI increased dietary uNDF, stabilized ruminal pH, stimulated more frequent reticulo-ruminal contractions, and may decrease the permeability of the gastrointestinal tract and systemic inflammation.
An Exploratory Study of Health-related Quality of Life and Care Experiences in Older Adults with Inflammatory Bowel Disease
Authors: Rohatinsky Noelle , Cave Janelle , Fowler Sharyle , Risling Tracie , Peña-Sánchez Juan Nicolás 
Published: February 2023

Abstract
Canada has one of the highest rates of inflammatory bowel disease (IBD), with older adults as the fastest-growing group of individuals affected. This exploratory mixed methods study aimed to understand perceived health-related quality of life and care experiences in older adults with IBD. Participants greater than 60 years of age, who were diagnosed with IBD, and who lived in Saskatchewan, Canada were invited to participate in both an online survey and telephone interview. Seventy-three respondents completed the survey, and 18 participants were interviewed. Most individuals were diagnosed before age 60, believed their IBD was well controlled, believed their current treatment was useful, and were satisfied with their care. Individuals also reported a moderate health-related quality of life. However, collaborative management of IBD care between providers and older adults with IBD was identified as an area with room for improvement. Strategies to enhance disease self-management and engaged chronic illness care are critical.
Equivalent Colony Growth of Hybrids of Two Invasive Coptotermes Species Can Threaten Urban Areas
Authors: Patel Jayshree S , Lee Sang-Bin , Chouvenc Thomas , Su Nan-Yao 
Published: February 2023

Abstract
Coptotermes formosanus Shiraki and C. gestroi (Wasmann) are economically important structural pests in urban areas. Due to anthropogenic activity, both species have been introduced into the United States, with their respective invasive ranges now overlapping in Florida, and the two species have the capability to hybridize. The potential for structural damage from subterranean termite colonies primarily depends on colony size. However, long-term colony growth and wood consumption capabilities of hybrid Coptotermes colonies remain to be investigated, to determine the potential pest status of field-established hybrid colonies. In this study, we investigated long-term colony development over four years to determine if aging hybrid colonies display vigor in terms of colony growth. In addition, we compared wood consumption rate of hybrid colonies to compare their potential impact as structural pests with the two parental species. In aging colonies (four-year-old), both hybrid mating types displayed a colony growth equivalent to C. formosanus. However, the wood consumption rates of four-year-old colonies of the two parental Coptotermes species and their hybrids were similar, indicating equal damaging potential. We also found multiple secondary reproductives in hybrid colonies, even in the presence of primary reproductives, which may favor their potential establishment and spread. Although hybrid colonies or hybrid alates have yet to be detected in the field, our results suggest that such hybrid colonies would be an additional termite threat in the future if they were established in the field.