bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dice of sensation: envisioning the phenomenological dimension of ecology
Authors: de la O Cabrera Manuel Rodrigo 
Published: January 2023

Contemporary ecological discourse in architecture is often built upon an approach based on quantitative parameters, characterised by the use of scientific data for environmentally sound architectural design. This article questions how such an ecological approach relates to the architectural image, experience, and inhabitation.Through two archetypical projects - Siegfried Ebeling’s Wohnkubus (1926) and Cedric Price’s Generator (1976-9) – this article examines a possible theory of ecologically oriented architecture which engages aesthetic values related to the human experience of architectural space. The projects are separated by the same fifty-year gap that separates Generator from present day, and the article therefore tries to reveal if and how both archetypes could suggest the need for an updated model for environmental design. What can we learn from these projects, and how do the Wohnkubus and Generator unveil other modelling practices? Is architecture today capable of (or even entitled to) producing exemplary representations committed to the ethical dimension of the global change?
Explaining candidate turnover. Evidence from a comparative analysis in 10 European established democracies with a list-PR system
Authors: Muyters Gertjan , Maddens Bart 
Published: January 2023

AbstractThis article investigates determinants of candidate turnover in 10 European established democracies with list-PR electoral systems. We identify party and election variables that affect the supply and demand of new candidates on the parties’ lists. In addition, we apply a weighted candidate turnover measure to investigate the dynamic of renewal on high-ranked list positions. We built an original dataset that contains 3344 electoral lists of represented political parties. Hypotheses are tested by means of a multilevel analysis of political party list renewal rates. At the party level, leadership change and larger party size in terms of members are found to coincide with higher general turnover. At the system level, general turnover is higher in elections with closed lists and high electoral volatility. At higher positions on the list, candidate turnover appears not to be affected by the party- and system-level variables identified in the broader literature.
Some Like It Cold: The “Conundrum of Samail” Revisited
Authors: Ring Uwe , Glodny Johannes , Scharf Andreas , Hansman Reuben 
Published: January 2023

AbstractMost tectonic models consider that the “Samail subduction zone” was the only subduction zone at the mid‐Cretaceous convergent Arabian margin. We report four new Rb‐Sr multimineral isochron ages from high‐pressure (HP) rocks and a major shear zone of the uppermost Ruwi‐Yiti Unit of the Saih Hatat window in the Oman Mountains of NE Arabia. These ages demand a reassessment of the intraoceanic suprasubduction‐zone evolution that formed the Samail Ophiolite and its metamorphic sole in the Samail subduction zone. Our new ages constrain waning HP metamorphism of the Ruwi subunit at ∼99‐96 Ma and associated deformation in the Yenkit shear zone between ∼104 and 93 Ma. Our ages for late stages of deformation and HP metamorphism (thermal gradients of ∼8–10°C km−1) overlap with published ages of ∼105‐102 Ma for Samail‐subduction‐zone prograde‐to‐peak metamorphism (thermal gradients of ∼20–25°C km−1), subsequent decompressional partial melting of the metamorphic sole and suprasubduction‐zone crystallization of the Samail Ophiolite (thermal gradients of ∼30°C km−1) between ∼100 and 93 Ma. Thermal considerations demand that two subduction zones existed at the mid‐Cretaceous Arabian margin. High‐pressure metamorphism of the Ruwi‐Yiti rocks occurred in a mature, thermally equilibrated “Ruwi subduction zone” that formed at ∼110 Ma. Initiation of the infant, thermally unequilibrated and, thus, immature, outboard intraoceanic Samail subduction zone occurred at ∼105 Ma. The Samail Ophiolite and its metamorphic sole were then thrust over the exhuming Ruwi‐Yiti HP rocks and onto the Arabian margin after ∼92 Ma, while the bulk of the Saih Hatat HP rocks below the Ruwi‐Yiti Unit started to be underthrust in the Ruwi subduction zone.
Molecular profiling of EBV associated diffuse large B-cell lymphoma
Authors: Frontzek Fabian , Staiger Annette M. , Wullenkord Ramona , Grau Michael , Zapukhlyak Myroslav , Kurz Katrin S. , Horn Heike , Erdmann Tabea , Fend Falko , Richter Julia , Klapper Wolfram , Lenz Peter , Hailfinger Stephan , Tasidou Anna , Trautmann Marcel , Hartmann Wolfgang , Rosenwald Andreas , Quintanilla-Martinez Leticia , Ott German , Anagnostopoulos Ioannis , Lenz Georg 
Published: January 2023

AbstractEpstein-Barr virus (EBV) associated diffuse large B-cell lymphoma (DLBCL) represents a rare aggressive B-cell lymphoma subtype characterized by an adverse clinical outcome. EBV infection of lymphoma cells has been associated with different lymphoma subtypes while the precise role of EBV in lymphomagenesis and specific molecular characteristics of these lymphomas remain elusive. To further unravel the biology of EBV associated DLBCL, we present a comprehensive molecular analysis of overall 60 primary EBV positive (EBV+) DLBCLs using targeted sequencing of cancer candidate genes (CCGs) and genome-wide determination of recurrent somatic copy number alterations (SCNAs) in 46 cases, respectively. Applying the LymphGen classifier 2.0, we found that less than 20% of primary EBV + DLBCLs correspond to one of the established molecular DLBCL subtypes underscoring the unique biology of this entity. We have identified recurrent mutations activating the oncogenic JAK-STAT and NOTCH pathways as well as frequent amplifications of 9p24.1 contributing to immune escape by PD-L1 overexpression. Our findings enable further functional preclinical and clinical studies exploring the therapeutic potential of targeting these aberrations in patients with EBV + DLBCL to improve outcome.
Effects of nanopillars and surface coating on dynamic traction force
Authors: Cheng Yijun , Pang Stella W. 
Published: January 2023

AbstractThe extracellular matrix serves as structural support for cells and provides biophysical and biochemical cues for cell migration. Topography, material, and surface energy can regulate cell migration behaviors. Here, the responses of MC3T3-E1 cells, including migration speed, morphology, and spreading on various platform surfaces, were investigated. Polydimethylsiloxane (PDMS) micropost sensing platforms with nanopillars, silicon oxide, and titanium oxide on top of the microposts were fabricated, and the dynamic cell traction force during migration was monitored. The relationships between various platform surfaces, migration behaviors, and cell traction forces were studied. Compared with the flat PDMS surface, cells on silicon oxide and titanium oxide surfaces showed reduced mobility and less elongation. On the other hand, cells on the nanopillar surface showed more elongation and a higher migration speed than cells on silicon oxide and titanium oxide surfaces. MC3T3-E1 cells on microposts with nanopillars exerted a larger traction force than those on flat PDMS microposts and had more filopodia and long protrusions. Understanding the relationships between platform surface condition, migration behavior, and cell traction force can potentially lead to better control of cell migration in biomaterials capable of promoting tissue repair and regeneration.
Evidence that endosperm turgor pressure both promotes and restricts seed growth and size
Authors: Creff Audrey , Ali Olivier , Bied Camille , Bayle Vincent , Ingram Gwyneth , Landrein Benoit 
Published: January 2023

AbstractIn plants, as in animals, organ growth depends on mechanical interactions between cells and tissues, and is controlled by both biochemical and mechanical cues. Here, we investigate the control of seed size, a key agronomic trait, by mechanical interactions between two compartments: the endosperm and the testa. By combining experiments with computational modelling, we present evidence that endosperm pressure plays two antagonistic roles: directly driving seed growth, but also indirectly inhibiting it through tension it generates in the surrounding testa, which promotes wall stiffening. We show that our model can recapitulate wild type growth patterns, and is consistent with the small seed phenotype of the haiku2 mutant, and the results of osmotic treatments. Our work suggests that a developmental regulation of endosperm pressure is required to prevent a precocious reduction of seed growth rate induced by force-dependent seed coat stiffening.
Molecular versatility during pluripotency progression
Authors: Furlan Giacomo , Huyghe Aurélia , Combémorel Noémie , Lavial Fabrice 
Published: January 2023

AbstractA challenge during development is to ensure lineage segregation while preserving plasticity. Using pluripotency progression as a paradigm, we review how developmental transitions are coordinated by redeployments, rather than global resettings, of cellular components. We highlight how changes in response to extrinsic cues (FGF, WNT, Activin/Nodal, Netrin-1), context- and stoichiometry-dependent action of transcription factors (Oct4, Nanog) and reconfigurations of epigenetic regulators (enhancers, promoters, TrxG, PRC) may confer robustness to naïve to primed pluripotency transition. We propose the notion of Molecular Versatility to regroup mechanisms by which molecules are repurposed to exert different, sometimes opposite, functions in close stem cell configurations.
Terrestrial invasive species alter marine vertebrate behaviour
Authors: Gunn Rachel L. , Benkwitt Cassandra E. , Graham Nicholas A. J. , Hartley Ian R. , Algar Adam C. , Keith Sally A. 
Published: January 2023

AbstractHuman-induced environmental changes, such as the introduction of invasive species, are driving declines in the movement of nutrients across ecosystems with negative consequences for ecosystem function. Declines in nutrient inputs could thus have knock-on effects at higher trophic levels and broader ecological scales, yet these interconnections remain relatively unknown. Here we show that a terrestrial invasive species (black rats, Rattus rattus) disrupts a nutrient pathway provided by seabirds, ultimately altering the territorial behaviour of coral reef fish. In a replicated ecosystem-scale natural experiment, we found that reef fish territories were larger and the time invested in aggression lower on reefs adjacent to rat-infested islands compared with rat-free islands. This response reflected changes in the economic defendability of lower-quality resources, with reef fish obtaining less nutritional gain per unit foraging effort adjacent to rat-infested islands with low seabird populations. These results provide a novel insight into how the disruption of nutrient flows by invasive species can affect variation in territorial behaviour. Rat eradication as a conservation strategy therefore has the potential to restore species interactions via territoriality, which can scale up to influence populations and communities at higher ecological levels.
Detecting macroevolutionary genotype–phenotype associations using error-corrected rates of protein convergence
Authors: Fukushima Kenji , Pollock David D. 
Published: January 2023

AbstractOn macroevolutionary timescales, extensive mutations and phylogenetic uncertainty mask the signals of genotype–phenotype associations underlying convergent evolution. To overcome this problem, we extended the widely used framework of non-synonymous to synonymous substitution rate ratios and developed the novel metric ωC, which measures the error-corrected convergence rate of protein evolution. While ωC distinguishes natural selection from genetic noise and phylogenetic errors in simulation and real examples, its accuracy allows an exploratory genome-wide search of adaptive molecular convergence without phenotypic hypothesis or candidate genes. Using gene expression data, we explored over 20 million branch combinations in vertebrate genes and identified the joint convergence of expression patterns and protein sequences with amino acid substitutions in functionally important sites, providing hypotheses on undiscovered phenotypes. We further extended our method with a heuristic algorithm to detect highly repetitive convergence among computationally non-trivial higher-order phylogenetic combinations. Our approach allows bidirectional searches for genotype–phenotype associations, even in lineages that diverged for hundreds of millions of years.
Low Quantitative Blush Evaluator score predicts larger infarct size and reduced left ventricular systolic function in patients with STEMI regardless of diabetes status
Authors: Nabrdalik Katarzyna , Tomasik Andrzej , Irlik Krzysztof , Hendel Mirela , Kwiendacz Hanna , Radzik Edyta , Pigoń Katarzyna , Młyńczak Tomasz , Gumprecht Janusz , Nowalany-Kozielska Ewa , Lip Gregory Y. H. 
Published: January 2023

AbstractType 2 diabetes mellitus (T2DM) and diminished myocardial perfusion increase the risk of heart failure (HF) and/or all-cause mortality during 6-year follow up following primary percutaneous coronary intervention (pPCI) for ST elevation myocardial infarction (STEMI). The aim of the present study was to evaluate the impact of myocardial perfusion on infarct size and left ventricular ejection fraction (LVEF) in patients with T2DM and STEMI treated with pPCI. This is an ancillary analysis of an observational cohort study of T2DM patients with STEMI. We enrolled 406 patients with STEMI, including 104 with T2DM. Myocardial perfusion was assessed with the Quantitative Myocardial Blush Evaluator (QUBE) and infarct size with the creatine kinase myocardial band (CK-MB) maximal activity and troponin area under the curve. LVEF was measured with biplane echocardiography using Simpson’s method at admission and hospital discharge. Analysis of covariance was used for modeling the association between myocardial perfusion, infarct size and left ventricular systolic function. Patients with T2DM and diminished perfusion (QUBE below median) had the highest CK-MB maximal activity (252.7 ± 307.2 IU/L, P < 0.01) along with the lowest LVEF (40.6 ± 10.0, P < 0.001). Older age (p = 0.001), QuBE below median (p = 0.026), and maximal CK-MB activity (p < 0.001) were independent predictors of LVEF. Diminished myocardial perfusion assessed by QuBE predicts significantly larger enzymatic infarct size and lower LVEF among patients with STEMI treated with pPCI, regardless of diabetes status.
A new long-snouted marine reptile from the Middle Triassic of China illuminates pachypleurosauroid evolution
Authors: Xu Guang-Hui , Shang Qing-Hua , Wang Wei , Ren Yi , Lei Hong , Liao Jun‑Ling , Zhao Li‑Jun , Li Chun 
Published: January 2023

AbstractSauropterygia is the largest, most successful group of Mesozoic marine diapsids, spanning from the late Early Triassic to the Late Cretaceous. Plesiomorphic for sauropterygians, pachypleurosauroids are important for our understanding on the early evolution of this group. Here, we present a new pachypleurosaurid,Luopingosaurus imparilisgen. et sp. nov., based on an exceptionally preserved skeleton from the early Middle Triassic Luoping Lagerstätte in Yunnan, China. The discovery documents the first long-snouted pachypleurosaurid with an unexpected hyperphalangy in the manus, providing new insights into the morphological diversification, ecological adaption and biogeographic evolution of this clade. The discovery further indicates that there is a morphological divergence between short-snouted (brevirostrine) keichousaurids and relatively long-snouted (longirostrine) pachypleurosaurids, which was probably driven by ecological specializations related to feeding and foraging. Additionally, an evolutionary trend towards the reduction of the ratio of the hyoid length to mandibular length (HM ratio) is recognized in pachypleurosauroids. This reduction of HM ratio, associated with the increase of the snout length, might implicate a gradual recession of suction feeding in pachypleurosauroid evolution. Phylogenetic studies incorporatingLuopingosaurusrecover European pachypleurosaurids as successive sister groups to Chinese derived pachypleurosaurids, supporting a western Tethyan origin for this family.
Dialects in leaf-clipping and other leaf-modifying gestures between neighbouring communities of East African chimpanzees
Authors: Badihi Gal , Graham Kirsty E. , Fallon Brittany , Safryghin Alexandra , Soldati Adrian , Zuberbühler Klaus , Hobaiter Catherine 
Published: January 2023

AbstractDialects are a cultural property of animal communication previously described in the signals of several animal species. While dialects have predominantly been described in vocal signals, chimpanzee leaf-clipping and other ‘leaf-modifying’ gestures, used across chimpanzee and bonobo communities, have been suggested as a candidate for cultural variation in gestural communication. Here we combine direct observation with archaeological techniques to compare the form and use of leaf-modifying gestures in two neighbouring communities of East African chimpanzees. We found that while both communities used multiple forms, primarily within sexual solicitation, they showed a strong preference for a single, different gesture form. The observed variation in form preference between these neighbouring communities within the same context suggests that these differences are, at least in part, socially derived. Our results highlight an unexplored source of variation and flexibility in gestural communication, opening the door for future research to explore socially derived dialects in non-vocal communication.
Study on shock vibration analysis and foundation reinforcement of large ball mill
Authors: Tie Qu , Biliang Tang , Qiang Bian , Xiangyun Zhang , Ming Chen , Chunjiang Zhao 
Published: January 2023

AbstractThe vibration of the ball mill foundation will seriously affect the operation stability of the ball mill. According to the connection relationship between the ball mill and the foundation, the mill-foundation transient shock model is established. The effects of shock force, concrete grade and shock angle on the transient response of the foundation were studied. And based on the problem of the mill foundation, the reinforcement scheme of the foundation was put forward. The following conclusions are drawn: with the increase of shock force and shock angle, the displacement of foundation joints increases, and the maximum stress also increases; concrete grade has little effect on foundation stability; after the foundation reinforcement scheme is used, the vibration caused by the shock of the ball mill is effectively reduced, and the stability of the foundation is increased. Finally, the correctness of the model and the scheme is verified through the comparison with the test data. The calculation results provide a reference for the improvement of the ball mill foundation.
Characterisation of N-linked protein glycosylation in the bacterial pathogen Campylobacter hepaticus
Authors: McDonald Jamieson B. , Scott Nichollas E. , Underwood Greg J. , Andrews Daniel M. , Van Thi Thu Hao , Moore Robert J. 
Published: January 2023

AbstractCampylobacter hepaticus is an important pathogen which causes Spotty Liver Disease (SLD) in layer chickens. SLD results in an increase in mortality and a significant decrease in egg production and therefore is an important economic concern of the global poultry industry. The human pathogen Campylobacter jejuni encodes an N-linked glycosylation system that plays fundamental roles in host colonization and pathogenicity. While N-linked glycosylation has been extensively studied in C. jejuni and is now known to occur in a range of Campylobacter species, little is known about C. hepaticus glycosylation. In this study glycoproteomic analysis was used to confirm the functionality of the C. hepaticus N-glycosylation system. It was shown that C. hepaticus HV10T modifies > 35 proteins with an N-linked heptasaccharide glycan. C. hepaticus shares highly conserved glycoproteins with C. jejuni that are involved in host colonisation and also possesses unique glycoproteins which may contribute to its ability to survive in challenging host environments. C. hepaticus N-glycosylation may function as an important virulence factor, providing an opportunity to investigate and develop a better understanding the system’s role in poultry infection.
Identifying metabolic shifts in Crohn's disease using 'omics-driven contextualized computational metabolic network models
Authors: Fernandes Philip , Sharma Yash , Zulqarnain Fatima , McGrew Brooklyn , Shrivastava Aman , Ehsan Lubaina , Payne Dawson , Dillard Lillian , Powers Deborah , Aldridge Isabelle , Matthews Jason , Kugathasan Subra , Fernández Facundo M. , Gaul David , Papin Jason A. , Syed Sana 
Published: January 2023

AbstractCrohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract. A clear gap in our existing CD diagnostics and current disease management approaches is the lack of highly specific biomarkers that can be used to streamline or personalize disease management. Comprehensive profiling of metabolites holds promise; however, these high-dimensional profiles need to be reduced to have relevance in the context of CD. Machine learning approaches are optimally suited to bridge this gap in knowledge by contextualizing the metabolic alterations in CD using genome-scale metabolic network reconstructions. Our work presents a framework for studying altered metabolic reactions between patients with CD and controls using publicly available transcriptomic data and existing gene-driven metabolic network reconstructions. Additionally, we apply the same methods to patient-derived ileal enteroids to explore the utility of using this experimental in vitro platform for studying CD. Furthermore, we have piloted an untargeted metabolomics approach as a proof-of-concept validation strategy in human ileal mucosal tissue. These findings suggest that in silico metabolic modeling can potentially identify pathways of clinical relevance in CD, paving the way for the future discovery of novel diagnostic biomarkers and therapeutic targets.