bluuebunny/crossref_metadata_2025_split huggingface dataset:
DÖRDÜNCÜ ENDÜSTRİ DEVRİMİ VE MODA ENDÜSTRİSİNE ETKİLERİ
Authors: YILDIRAN Mine 
Published: December 2022

Endüstri devriminin başlangıcı olarak kabul edilen 18. yüzyıldan günümüze bilim ve teknolojideki
gelişmeler endüstrileşme sürecini oluşturmuş ve bu süreç belirli dönemlere ayrılmıştır. 20. yüzyıl sonlarından
itibaren bilim ve teknolojideki ilerlemelerle endüstride ortaya çıkan gelişmeler Dördüncü Endüstri Devrimi
olarak tanımlanmaktadır. Dördüncü Endüstri Devrimi robotik, yapay zekâ, özerk taşıtlar, nesnelerin
interneti, üç boyutlu yazıcılar, nano-teknoloji, biyo-teknoloji, malzeme bilimi gibi çok çeşitli alanlarda
yenilikçi teknolojik atılımları kapsamaktadır. Yeniliklerin çok daha hızlı bir biçimde dünyayı şekillendirdiği
21. yüzyılda moda endüstrisi de değişimlerden etkilenmektedir. Çalışma bu süreçte moda endüstrisinde
meydana gelen değişimleri ürün tasarımı, üretimi, satış ve dağıtım başlıkları çerçevesinde incelemektedir.
Süreçte ortaya çıkan durumun betimlenmesi, moda tasarımcıları ve üreticileri için oluşturacağı fırsat ve
güçlüklerin açıklanması amaçlamaktadır. Araştırma süreçte ortaya çıkan bu yenilikleri sınıflandırarak,
daha sonra ortaya çıkabilecek yenilikleri takip etmek isteyen tasarımcı ve araştırmacılar için bir yol haritası
geliştirilmesi hedeflemektedir. Çalışmada Dördüncü Endüstri Devrimi kapsamında genel eğilimlerin moda
endüstrisine yansıması olarak ortaya çıkan yeni uygulamalar açıklanarak, metin betimleyici örneklerle
zenginleştirilmektedir.
Robust Estimation Method Using Successive Approximation Algorithm to Correct Errors
Authors: YE Xiao-ming 
Published: December 2022

Abstract
In measurement practice, the residuals in least squares adjustment usually show various abnormal discrete distributions, including outliers, which is not conducive to the optimization of final measured values. In this paper, according to the physical mechanism of deviation, dispersion and outlier of repeated observations, it can be seen that abnormal distribution and outlier are normal measurement phenomena, and weakening the influence of outlier is an incorrect research direction. Then, by revealing the advantages of functional model processing, this paper puts forward the error correction idea of using the approximate function model to approach the actual function model step by step, and forms a new theoretical method to optimize the final measured values, which greatly improves the quality of measured values. This is a new measurement theory idea that is completely different from mainstream robust estimation research.
Topological reorganization of functional hubs in Parkinson’s disease patients with freezing of gait.
Authors: Sreeniva Karthik , Bayram Ece , Zhuang Xiaowei , Longhurst Jason , Yang Zhengshi , Cordes Dietmar , Ritter Aaron , Caldwell Jessica , Cummings Jeffrey , Mari Zoltan , Litvan Irene , Bluett Brent , Mishra Virendra 
Published: December 2022

Abstract
Resting-state functional MRI (rs-fMRI) studies in Parkinson’s disease (PD) patients with freezing of gait (FOG) have implicated dysfunctional connectivity over multiple resting-state networks. While these findings provided network-specific insights and information related to the aberrant or altered regional functional connectivity, whether these alterations have any effect on topological reorganization in PD-FOG patients is incompletely understood. Understanding higher-order functional organization, which could be derived from the ‘hub’ and the ‘rich-club’ organization of the functional networks could be crucial to identifying the distinct and unique pattern of the network connectivity associated with PD-FOG. In this study, we use rs-fMRI data and graph theoretical approaches to explore the reorganization of resting-state network topology in PD-FOG when compared to those without FOG (PD-nFOG). We also compared the higher-order functional organization derived using the hub and rich-club measures in the functional connectivity networks of these PD-FOG patients to understand whether there is a topological reorganization of these hubs in PD-FOG. We found that the PD-FOG patients showed a noticeable reorganization of ‘hub’ regions. Regions that are part of the prefrontal cortex, primary somatosensory, motor, and visuomotor coordination areas showed were some of the regions exhibiting altered ‘hub’ measures in PD-FOG patients. We also found significantly altered feeder and local connectivity in PD-FOG. Overall our findings demonstrate a widespread topological reorganization and disrupted higher-order functional network topology in PD-FOG which may further assist in improving our understanding of functional network disturbances associated with PD-FOG.
Quantifying Uncertainties in CERES/MODIS Downwelling Radiation Fluxes in the Global Tropical Oceans
Authors: Thandlam Venugopal 
Published: December 2022

Abstract

The Clouds and the Earth's Radiant Energy System (CERES) program, which uses the Moderate Resolution Imaging Spectroradiometer (MODIS) (CM), has been updated with the launch of new satellites and the availability of newly upgraded radiation data. The spatial and temporal variability of daily averaged synoptic 1-degree (SYN1deg) CM version 3 (CMv3) (old) and version 4 (CMv4) (new) downwelling shortwave (QS) and longwave radiation (QL) data in the global tropical oceans spanning 30oS-30oN from 2000 to 2017 is investigated. Daily in situ data from the Global Tropical Moored Buoy Array (GTMBA) were used to validate the CM data from 2000 to 2015. When compared to CMv3, both QS and QL in CMv4 show significant improvements in bias, root-mean-square error, and standard deviations. Furthermore, a long-term trend analysis shows that QS has been increasing by 1 Wm− 2 per year in the Southern Hemisphere. In contrast, the Northern Hemisphere has a -0.7 Wm− 2 annual decreasing trend. QS and QL exhibit similar spatial trend patterns. However, in the Indian Ocean, Indo-Pacific warm pool region, and Southern Hemisphere, QL spatial patterns in CMv3 and CMv4 differ with an opposite trend (0.5 Wm− 2). These annual trends in QS and QL could cause the sea surface temperature (SST) to change by -0.2 to 0.3°C per year in the tropical oceans. These results stress the importance of accurate radiative flux data, and CMv4 can be an alternative to reanalysis or other model-simulated data.
Effectiveness of Lyophilized Growth Factors Injection for Subacromial Impingement Syndrome: A Prospective Randomized Double-Blind Placebo Controlled Study
Authors: El-Sherif Sherine Mahmoud , Moustafa Mowaffak , Ashraf Jailan , Fahmy Hossam , Abdel-Naby Hoda 
Published: December 2022

Abstract
Background
Platelet-derived lyophilized growth factors (L-GF) uses a standardized number of allogenic pathogen-free platelets instead of autologous platelets used in PRP as a source of growth factors. This study aimed to evaluate the efficacy of L-GF injection versus placebo in the treatment of subacromial impingement (SIS).
Methods
The current randomized double-blind placebo-controlled study included sixty patients (40 females and 20 males, aged between 24-75 years) diagnosed with SIS (both clinically and sonographically). Patients were randomly assigned to two equal groups. Group 1 received subacromial saline injection, and group 2 received L-GF injection. Both groups were injected under ultrasound guidance. Clinical examination, Visual analogue scale (VAS) of pain, Shoulder Pain and Disability Index (SPADI), and shoulder ultrasound were performed before and at the 8th week after injection.
Results
Follow-up assessment showed statistically significant improvement in the L-GF group with regard to active flexion, active and passive internal rotation and extension, SPADI-Disability scale, VAS of pain and thickness of the supraspinatus tendon by US. Concerning painful arc, regression analysis showed that the placebo group was approximately 30 times more likely than the L-GF group to experience painful arc at follow-up. Both groups showed statistically significant improvement regarding the SPADI-Pain scale and SPADI-Total as well as passive flexion and abduction (still the mean value of abduction was significantly higher in the L-GF group).
Conclusions
L-GF injection resulted in clinically significant reductions in pain and functional disability outcomes in patients with SIS. An objective significant reduction in the thickness of the supraspinatus tendon, measured by ultrasound, in the L-GF group hopefully encourages proper healing and functioning in SIS.
Trial registration:
The identification number is NCT04330027, date of first registration (01/04/2020).
Unique on 21/11/2019, Protocol ID: 0106178,
Histological Assessment of Cortical Bone Changes in Diabetic Rats
Authors: Minami Masataka , Ikoma Kazuya , Onishi Okihiro , Horii Motoyuki , Itoh Kyoko , Takahashi Kenji 
Published: December 2022

Abstract
Background: Diabetes mellitus weakens bone strength due to deterioration of bone quality; however, the histological mechanisms are still unknown. We hypothesized that histological assessment of cortical bone would enable us to determine the cause of the bone strength reduction associated with diabetes mellitus. Our aim was to evaluate the histomorphometric changes of cortical bone associated with deterioration of intrinsic bone properties and bone quality in diabetes mellitus.
Methods: We compared the outcomes of mechanical tests, bone mineral density measured using micro computed tomography, and histological assessments, by applying Villanueva’s bone stain, to the tibial bones of 40-week-old diabetic and control male rats.
Results: With respect to mechanical testing, the maximum load and energy absorption were significantly lower in the diabetic than in the control group, although fracture displacement and stiffness were not significantly different between the two groups. Bone mineral density was significantly higher in the diabetic group than in the control group. Bone histomorphometry revealed that the diabetic rats had fewer osteocytes, greater cortical porosity, and increased mineralization in cortical bone compared with the control group.
Conclusions: Increased mineralization of the cortical bone with greater cortical porosity leads to a weakening of bone strength in diabetes mellitus.
A systematic review of biologically-informed deep learning models for cancer: fundamental trends for encoding and interpreting oncology data
Authors: Wysocka Magdalena , Wysocki Oskar , Zufferey Marie , Landers Donal , Freitas Andre 
Published: December 2022

Abstract
Background There is an increasing interest in the use of Deep Learning (DL) based methods as a supporting analytical framework in oncology. However, most direct applications of DL will deliver models with limited transparency and explainability, which constrain their deployment in biomedical settings.
Methods This systematic review discusses DL models used to support inference in cancer biology with a particular emphasis on multi-omics analysis. It focuses on how existing models address the need for better dialogue with prior knowledge, biological plausibility and interpretability, fundamental properties in the biomedical domain. For this, we retrieved and analyzed 42 studies focusing on emerging architectural and methodological advances, the encoding of biological domain knowledge and the integration of explainability methods.
Results We discuss the recent evolutionary arch of DL models in the direction of integrating prior biological relational and network knowledge to support better generalisation (e.g. pathways or Protein-Protein-Interaction networks) and interpretability. This represents a fundamental functional shift towards models which can integrate mechanistic and statistical inference aspects. We introduce a concept of bio-centric interpretability and according to its taxonomy, we discuss representational methodologies for the integration of domain prior knowledge in such models.
Conclusions The paper provides a critical outlook into contemporary methods for explainability and interpretabiltiy used in DL for cancer. The analysis points in the direction of a convergence between encoding prior knowledge and improved interpretability. We introduce bio-centric interpretability which is an important step towards formalisation of biological interpretability of DL models and developing methods that are less problem- or application-specific.
The longstanding galaxy missing-baryon problem is solved by a large reservoir of hot gas permeating their halos
Authors: Nicastro Fabrizio , Krongold Yair , Fang Taotao , Fraternali Filippo , Mathur Smita , Bianchi Stefano , Bongiorno Angela , De Rosa Alessandra , Piconcelli Enrico , Zappacosta Luca , Bischetti Manuela , Feruglio Chiara , Gupta Anjali 
Published: December 2022

Abstract
The amount of baryons hosted in the disks of galaxies (stars and interstellar gas and dust) is lower than expected based on the mass of their dark-matter halos and the fraction of baryon-to-total matter in the universe[1], giving rise to the so called galaxy missing-baryon problem (e.g. [2]). The presence of cool circum-galactic matter gravitationally bound to its galaxy’s halo up to distances of at least ten times the size of the galaxy’s disk (e.g. [3-13]), mitigates the problem but is far from being sufficient for its solution. It has instead been suggested (e.g. [14]), that the galaxy missing baryons may hide in a much hotter gaseous phase of the circum-galactic medium, possibly at the halo virial temperature and co-existing with the cool phase. Here we exploit the best available X-ray spectroscopic data of known cool circum-galactic absorbers to show that the galaxy missing baryonic mass is indeed found in a hot medium permeating galaxy halos, at temperatures consistent with their virial temperatures. Main tracers of this hot medium are highly ionized light elements that only retain one or two electrons and that are only visible in the X-rays. Our measurements solve the long-standing galaxy missing baryon problem and thus significantly contribute to the understanding of the continuous cycle of baryons in- and-out of galaxies throughout the life of the universe.
Transanal end-to-end rectoanal pullthrough for treatment of rectal atresia: A review of 4 cases
Authors: Shehata Sameh , Elsawaf Mohamed , Kotb Mostafa 
Published: December 2022

Abstract
Introduction: Rectal atresia is a rare subtype of anorectal malformations in which the patients are born with a normal anal canal but have complete atresia located few centimeters proximal to the dentate line. We present the transanal end-to-end rectoanal anastomosis as a surgical technique for the management of these patients, highlight the outcomes, and emphasize on some clinical tips.
Methods: Four patients were diagnosed as having rectal atresia on clinical and radiological basis. All of them underwent single loop low sigmoid colostomy in the first 24 hours. After 6 months, transanal end-to-end rectoanal anastomosis was performed followed by closure of the stoma 3 months later.
Results: The 2 cases that are older than 3 years demonstrated normal continence and are clean between bowel movements, while the other two showed good anal tone and passing stools between 1–3 times daily, being dry in between.
Conclusion: Transanal end-to-end rectoanal anastomosis allows a safer route of anatomical reconstruction of the anorectum, therefore avoiding the potential complications associated with the other more invasive approaches.
TRPM2 Regulates Neutrophil Extracellular Traps Formation and Delays Resolution of Neutrophil-driven Sterile Inflammation
Authors: Cao Xue , Li Yanhong , Luo Yubin , Chu Tianshu , Yang Hang , Wen Ji , Liu Yi , Zhao Yi , Herrmann Martin 
Published: December 2022

Abstract
The formation of neutrophil extracellular traps (NETs) is a process releasing into the extracellular space networks of chromatin fibers decorated with granular proteins. It is implicated in infection-related as well as sterile inflammation. Monosodium urate (MSU) crystals serve as damage-associated molecular pattern (DAMP) in various conditions of disease. Formation of NETs or aggregated NETs (aggNETs) orchestrates initiation and resolution of MSU crystals-triggered inflammation, respectively. Elevated intracellular calcium levels and the generation of reactive oxygen species (ROS) are crucial for the formation of MSU crystal-induced NETs. However, the exact signaling pathways involved are still elusive. Herein, we demonstrate that the ROS-sensing, non-selective calcium-permeable channel transient receptor potential cation channel subfamily M member 2 (TRPM2) is required for a full-blown MSU crystal-induced NET formation. Primary neutrophils from TRPM2-/- mice showed reduced calcium influx and ROS production and, consequently a reduced formation of MSU crystal-induced NETs and aggNETs. Furthermore, in TRPM2-/- mice the infiltration of inflammatory cells into infected tissues and their production of inflammatory mediators was suppressed. Taken together these results describe an inflammatory role of TRPM2 for neutrophil-driven inflammation and identify TRPM2 as potential target for therapeutic intervention.
Is Ventricular Lavage a Novel Treatment of Neonatal Posthemorrhagic Hydrocephalus? A Meta analysis
Authors: Parenrengi Muhammad Arifin , Ranuh I. G. M Aswin R. , Suryaningtyas Wihasto 
Published: December 2022

Abstract
Introduction
Intraventricular hemorrhage (IVH) may produce obliterative arachnoiditis, which disrupts the flow and absorption of cerebrospinal fluid (CSF), resulting in posthemorrhagic hydrocephalus (PHH). PHH gives a high risk of neurofunctional impairment.
Ventricular lavage is the treatment of choice for PHH in neonates with IVH for decades. It’s developing with the combination of fibrinolytic therapy also called drainage, irrigation and fibrinolytic therapy (DRIFT), and with the using of neuroendoscopic apparatus also called neuroendoscopic lavage (NEL).
Methods
This review is a meta-analysis using the PRISMA method guideline, including the clinical studies comparing ventricular lavage (VL) with standard treatment of PHH between 2000 and 2021.
Results
VL group reduce the shunt dependency compared to standard treatment (OR = 0.22; 95CI 0.05 to 0.97; p = 0.05). VL group has less infection risk compared to the standard treatment group (RR = 0.20; 95CI 0.07 to 0.59; p < 0.05). The severe neurofunctional outcome is similar between the two groups (OR = 0.99; 95CI 0.13 to 7.23; p = 0.99). The early approach treatment group may give better neurofunctional outcome compared to the late approach (OR = 0.14; 95CI 0.06 to 0.35; p < 0.05).
Conclusion
VL reduce the shunt dependency on the PHH, decreasing the shunt’s related infection rate. The early ventricular lavage may give benefit for the neurocognitive outcome.
Surgery for Pilonidal Sinus Disease in Norway: Training, Attitudes and Preferences. A Survey Among Norwegian Surgeons
Authors: Odlo Mari , Horn Julie , Xanthoulis Athanasios 
Published: December 2022

Abstract
Background: Pilonidal sinus disease (PSD) is frequently observed in young adults. There is no wide consensus on optimal treatment in the literature, and various procedures are used in clinical practice. The objective of this study was to assess current practice, experience, training, and attitudes towards PSD surgery among Norwegian surgeons.
Methods: An online survey on PSD surgery was created and sent to all members of the Norwegian Surgical Association. Categorical data were reported as frequencies and percentages.
Results: Most currently practicing Norwegian surgeons used the Bascom’s cleft lift (93.2%) or minimally invasive procedures (55.4%). Midline excisions with primary closure (19.7%) or secondary healing (22.4%) were still used by some surgeons, though. Most surgeons had received training in PSD surgery supervised by a specialist, but only about half of them felt sufficiently trained. The surgeons generally performed few PSD operations per year. Many considered PSD as a condition of low surgical status and this patient group as underprioritized.
Conclusions: Our findings suggest that PSD surgery in Norway has been moving away from midline excisions and towards off-midline flap procedures and minimally invasive techniques. PSD and its treatment have a low status among many Norwegian surgeons. This study calls for attention to this underprioritized group of patients and shows the need for consensus in PSD treatment such as development of national guidelines in Norway. Further investigation on training in PSD and the role of supervision is needed.
A hybrid multi-particle approach to range assessment-based treatment verification in particle therapy
Authors: Meric Ilker , Alagoz Enver , Hysing Liv , Kögler Toni , Lathouwers Danny , Lionheart William , Mattingly John , Obhodas Jasmina , Pausch Guntram , Pettersen Helge , Ratliff Hunter , Rovituso Marta , Schellhammer Sonja , Setterdahl Lena , Skjerdal Kyrre , Sterpin Edmond , Sudac Davorin , Turko Joseph , Ytre-Hauge Kristian 
Published: December 2022

Abstract
Particle therapy (PT) used for cancer treatment can spare healthy tissue and reduce treatment toxicity. However, full exploitation of the dosimetric advantages of PT is not yet possible due to range uncertainties, warranting development of range-monitoring techniques. This study proposes a novel range-monitoring technique introducing the yet unexplored concept of simultaneous detection and imaging of fast neutrons and prompt-gamma rays produced in beam-tissue interactions. A quasi-monolithic organic detector array is proposed, and its feasibility for detecting range shifts in the context of proton therapy is explored through Monte Carlo simulations of realistic patient models. The results indicate that range shifts of 1 mm can be detected at relatively low proton intensities (6 million/spot) when spatial information obtained through imaging of both particle species are used simultaneously. This study lays the foundation for multi-particle detection and imaging systems in the context range verification in PT.
Induction of tissue-specific premature stem cell aging via Lef1 deficiency promotes senescence-like deterioration in remote organs
Authors: Ikuno Yasuaki , Watanabe Koichiro , Kakeya Yumi , Ikeno Shinsuke , Nakabo Toshimasa , Narumoto Ayano , Kande Yukie , Hayashi Tomoki , Minami Kahori , Nobuhiro Kasumi , Mabuchi Yo , Nakamura Shiho , Okano Hideyuki , Ihara Dai , Katsuyama Yu , Naka-Kaneda Hayato 
Published: December 2022

Abstract
Molecular mechanisms of aging specific to each stem cell (SC) are being elucidated. However, the common molecular basis for senescence in various SCs remains largely unexplored. Here, we have shown that the dysregulation of DNA damage response (DDR) modulated by lymphoid enhancer-binding factor 1 (Lef1) and DDR-microRNAs (DDR-miRs) is the common molecular basis for aging in SCs. We identified Lef1as the most repressed transcription factor with aging in common between mesenchymal stem/stromal cells (MSCs) and hematopoietic stem/progenitor cells. Like the expression profiles of aged MSCs, Lef1 knockdown reduced broad microRNAs and loss of induction of DDR-miRs in young MSCs. DDR capacity was also diminished in aged SCs in vivo. Moreover, Lef1 deficiency in intestinal stem cells induced precocious dysregulation of DDR and inflammation and senescence in the remote brain. This study demonstrates that the Lef1/DDR-miR axis is the common molecular basis underlying SC aging.