bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colonization of extended-spectrum β-lactamase-producing Enterobacteriaceae does not affect subsequent infection and liver transplant outcomes: a retrospective observational cohort study
Authors: Shang Chen , Yang Run , Yang Ya , Zhang Haomin , Zhang Jianjun , Xia Qiang , Gao Yuan , Deng Yuxiao 
Published: September 2023

ObjectiveTo investigate the colonization rate of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E), subsequent infections by ESBL-E and ESBL-producing gram-negative bacilli (ESBL-GNB), and the effect of ESBL-E colonization on clinical outcomes in liver transplantation (LT) recipients.MethodsThis is a retrospective cohort study that included patients who underwent LT at Shanghai Renji Hospital between July 2016 and December 2017. Rectal swabs from LT patients at the postoperative ICU enrollment were screened anonymously for ESBL-E carriage. Demographics data, laboratory indexes, operative complications, and clinical course information were also obtained. The extent of ESBL-E colonization, the subsequent infection rates of ESBL-E and ESBL-GNB, and the clinical outcomes were compared between ESBL-E colonized and non-colonized patients.ResultsIn total, 496 liver transplant recipients (387 males) were included in this study. ESBL-E colonization was detected in 240 patients (48.4%). There was no significant difference between the rates of ESBL-E infection (5.8 vs. 3.1%, p = 0.143), Ischemia-reperfusion ≥ 3 (27.9 vs. 24.6%, p = 0.403), acute kidney injury (39.6 vs. 38.7%, p = 0.835), acute rejection (2.1 vs. 1.6%, p = 0.664), graft versus host reaction (1.3 vs. 1.2%, p = 0.937), duration of hospitalization (22 vs. 23 days, p = 0.568), 90-day mortality (7.1 vs. 4.7%, p = 0.262) and 1-year mortality (12.9 vs. 9.3%, p = 0.265) in patients with and without ESBL-E colonization. Though the ESBL-GNB infection rate was higher in ESBL-E colonized patients (12.1 vs. 6.6%, p = 0.037), multivariate analysis showed that ESBL-E colonization did not increase the risk of ESBL-GNB infection (Model 1: aOR 1.755, 95% CI: 0.911–3.380, p = 0.093; Model 2: aOR 1.556, 95% CI: 0.761–3.181, p = 0.226). The ESBL-producing bacteria spectrum of colonization was significantly different from that of infections occurring after LT, with only three colonization events leading to infection by the same pathogen identified.ConclusionESBL-E colonization in liver transplant patients is not associated with ESBL-E infection, nor is it a risk factor for post-transplant ESBL-GNB infection. Additionally, ESBL-E colonization does not lead to worse prognoses when compared with non-colonized patients.Clinical trial registrationChinese Clinical Trial Registry, Identifier [ChiCTR2100043034].
Depression, anxiety and stress among healthcare workers in the context of the COVID-19 pandemic: a cross-sectional study in a tertiary hospital in Northern Vietnam
Authors: Thu Pham Hien , Viet Cao Tung , Bich Le Ngoc , T-T Nguyen Nhung , Thi Ngoc Vuong Bich , Vu Dieu Pham Linh , Thu Hoang Trang , Thi Hanh Pham Trang , Ngoc Nguyen Thuy , Thi Thu Bui Huong , Van Tran Tho , Thuy Vu Linh , Thi Le Phuong 
Published: September 2023

IntroductionThe outbreak of coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) had significant effects on the mental well-being in general, particularly for healthcare professionals. This study examined the prevalence of depression, anxiety, and stress, and identified the associated risk factors amongst healthcare workers during the COVID-19 outbreak in a tertiary hospital located in Vietnam.MethodsWe conducted a cross-sectional study at a tertiary-level hospital, where the Depression Anxiety and Stress Scale 21 (DASS-21) web-based questionnaire was employed. We analyzed the determinant factors by employing multivariate logistic models.ResultsThe prevalence of depression, anxiety, and stress symptoms were 19.2%, 24.7%, and 13.9%, respectively. Factors such as engaging in shift work during the pandemic, taking care of patients with COVID-19, and staff’s health status were associated with mental health issues among health professionals. In addition, having alternate rest periods was likely to reduce the risk of stress.ConclusionThe prevalence of mental health problems in healthcare workers during the COVID-19 pandemic was relatively high. Having resting periods could potentially mitigate the development of stress among health professionals. Our findings could be taken into account for improving mental health of the health professional population.
Effects of underweight and overweight on mortality in patients with pulmonary tuberculosis
Authors: Min Jinsoo , Kim Ju Sang , Kim Hyung Woo , Ko Yousang , Oh Jee Youn , Jeong Yun-Jeong , Lee Eun Hye , Yang Bumhee , Lee Ki Man , Ahn Joong Hyun , Kim Jin Woo , Hwang Yong Il , Lee Sung Soon , Park Jae Seuk , Koo Hyeon-Kyoung 
Published: September 2023

BackgroundPoor nutrition increases disease severity and mortality in patients with tuberculosis (TB). There are gaps in our understanding of the effects of being underweight or overweight on TB in relation to sex.MethodsWe generated a nationwide TB registry database and assessed the effects of body mass index (BMI) on mortality in patients with pulmonary TB. The cause of death was further classified as TB-related or non-TB-related deaths. First, logistic regression analysis was performed to assess the association between BMI (a continuous variable) and mortality, and subgroup analyses of the multivariable logistic regression model were performed separately in male and female patients. Second, we categorized BMI into three groups: underweight, normal weight, and overweight, and assessed the impact of being underweight or overweight on mortality with reference to normal weight.ResultsAmong 9,721 patients with pulmonary TB, the mean BMI was 21.3 ± 3.4; 1,927 (19.8%) were underweight, and 2,829 (29.1%) were overweight. In multivariable logistic regression analysis, mortality was significantly increased with the decrement of BMI (adjusted odds ratio [aOR] = 0.893, 95% confidence interval [CI] = 0.875–0.911). In subgroup analyses, underweight patients had significantly higher odds of mortality, especially TB-related deaths (aOR = 2.057, 95% CI = 1.546–2.735). The association with mortality and male patients was higher (aOR = 2.078, 95% CI = 1.717–2.514), compared with female patients (aOR = 1.724, 95% CI = 1.332–2.231). Being overweight had a significant protective effect against TB-related death only in females (aOR = 0.500, 95% CI = 0.268–0.934), whereas its effect on non-TB-related death was observed only in males (aOR = 0.739, 95% CI = 0.587–0.930).ConclusionBeing underweight was linked to high mortality, whereas being overweight had beneficial effects in patients with pulmonary TB.
Sleep disorders and suicide attempts following discharge from residential treatment
Authors: Bishop Todd M. , Youngren Westley A. , Klein John S. , Speed Katrina J. , Pigeon Wilfred R. 
Published: September 2023

IntroductionSuicide is a significant public health concern and its prevention remains a top clinical priority of the Veterans Health Administration. Periods of transition in care (e.g., moving from inpatient to outpatient care) represent a period of increased risk. Sleep disorders are prevalent amongst Veterans and are modifiable risk factor for suicide. The present study examined the relationship of sleep disorders to time to suicide attempt amongst Veterans known to have attempted suicide in the 180 days following discharge from a Mental Health Residential Rehabilitation Treatment Program.MethodThe present sample was comprised of all Veterans enrolled in services with the Veterans Health Administration known to have attempted suicide following discharge from a Mental Health Residential Rehabilitation Treatment Program during Fiscal Years 13 and 14 (N = 1,489). To create this sample, electronic medical record data were extracted from two VHA data sources: the Corporate Data Warehouse and the Suicide Prevention Application Network.ResultsCox regression models revealed that Veterans with a sleep disturbance (N = 1,211) had a shorter time to suicide attempt than those without a sleep disturbance [Hazard Ratio (HR) = 1.16, CI (1.02–1.32)]. A subsequent Cox regression model including age, insomnia, nightmare disorder, and alcohol dependence revealed that sleep-related breathing disorders [HR = 1.19, CI (1.01–1.38)], alcohol dependence [HR = 1.16, CI (1.02–1.33)], and age group were associated with increased risk.ConclusionFindings indicate that sleep disturbance, primarily driven by sleep-related breathing disorders, was associated with time to suicide attempt in this sample of high-risk Veterans known to have attempted suicide in the 180 days following their discharge from a Mental Health Residential Rehabilitation Treatment Program. These findings reveal an opportunity to reduce risk through the screening and treatment of sleep disorders in high-risk populations.
Seasonal patterns of oxidative stress markers in captive Asian elephants in Thailand and relationships to elephant endotheliotropic herpesvirus shedding
Authors: Kosaruk Worapong , Brown Janine L. , Towiboon Patcharapa , Pringproa Kidsadagon , Punyapornwithaya Veerasak , Tankaew Pallop , Kittisirikul Narueporn , Toonrongchang Wachiraporn , Janyamathakul Thittaya , Muanghong Panida , Thitaram Chatchote 
Published: September 2023

IntroductionOxidative stress refers to an imbalance between oxidant and antioxidant activity and accumulation of reactive oxygen species, which can have detrimental effects on animal health. Annual fluctuations in oxidative stress status can occur, increasing disease susceptibility during certain time periods. However, a full understanding of factors related to oxidative stress in Asian elephants and how to mitigate the negative consequences is lacking.MethodsThis study measured six serum oxidative stress markers [reactive oxygen species (ROS), malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), albumin, glutathione peroxidase (GPx), and catalase] and two stress markers [serum cortisol and fecal glucocorticoid metabolites (fGCM)] in 23 captive Asian elephants in Thailand over a 12 months period to examine relationships with age and season.ResultsSeasonal variations were observed, with several markers exhibiting significantly higher concentrations in the summer (ROS, MDA, 8-OHdG, albumin) and lower values during the rainy/winter seasons (MDA, 8-OHdG, albumin, catalase). By contrast, GPx was the only marker to be highest during the rainy season. For the stress markers, higher fGCM concentrations were noted during the rainy season, which contrasts with earlier studies showing more activity in the winter (tourist season). Positive correlations were found between the temperature-humidity index and ROS, GPx, and fGCM, while a negative correlation was observed with serum albumin. Elephant endotheliotropic herpesvirus (EEHV) shedding events were associated with higher concentrations of ROS and MDA. A moderate negative correlation was observed between 8-OHdG and the PCR threshold cycle of EEHV shedding (Ct), indicating DNA damage may be involved in EEHV shedding in elephants.DiscussionResults revealed significant age and seasonal effects on several oxidative stress markers, indicating those factors should be considered in study design and data interpretation. There also may be physiological adaptations in oxidative stress conditions in relation to environmental changes that could impact health outcomes.
Liver function tests in patients with hypertension in primary care: a prospective cohort study
Authors: Al Harthi Thuraiya , Whiting Penny , Watson Jessica 
Published: September 2023

BackgroundLiver function tests (LFTs) are frequently used to monitor patients with hypertension in UK primary care. Evidence is lacking on whether testing improves outcomes.AimTo estimate the diagnostic accuracy of LFTs in patients with hypertension and determine downstream consequences of testing.Design & settingProspective study using the Clinical Practice Research Datalink (CPRD).MethodIn total, 30 000 patients with hypertension who had LFTs in 2015 were randomly selected from CPRD. The diagnostic accuracy measures for eight LFT analytes and an overall LFT panel were calculated against the reference standard of liver disease. Rates of consultations, blood tests, and referrals within 6 months following testing were measured.ResultsThe 1-year incidence of liver disease in patients with hypertension was 0.5% (95% confidence interval [CI] = 0.4% to 0.6%). Sensitivity and specificity of an LFT panel were modest: 61.3% (95% CI = 53.1% to 69.0%) and 73.8% (95% CI = 73.1% to 74.3%), respectively. The positive predictive value (PPV) of the eight individual LFT analytes were low ranging from 0.2% to 8.9%. Among patients who did not develop liver disease, mean number of consultations, referrals, and tests were higher in the 6 months following false-positives at 10.5, 0.7 and 29.8, respectively, compared with true-negatives: 8.6, 0.6, and 19.8.ConclusionPPVs of LFTs in primary care were low, with high rates of false-positive results and increased rates of subsequent consultations, referrals, and blood testing. Avoiding LFTs for routine monitoring could potentially reduce patients’ anxiety, GP workload, and healthcare costs.
Role of Ki Hajar Dewantara in Instilling Character Education in Students
Authors: Barus Depitaria 
Published: September 2023

Penelitian ini membahas tentang peranan Ki Hajar Dewantara dalam menanamkan pendidikan karakter siswa yang terdapat dalam puisi Teratai karya Sanusi Pane. Kajian yang digunakan pada penelitian ini adalah hermeneutika pada sebuah puisi. Kajian ini digunakan karena kajian hermeneutika yang merupakan titik awal sebuah kajian sastra yang bersifat alternatif untuk memahami makna simbol-simbol dalam karya sastra. Jenis pendekatan yang digunakan pada penelitian ini adalah pendekatan deskriptif kualitatif dan sumber data yang diolah merupakan hasil dari analisis dokumendan telaah pustaka. Kajian hermeneutika pada puisi “Teratai” karya Sanusi Pane ini mengacu pada perkembangan zaman dan kanonisasi sastra yang beraneka ragam. Seorang penyair atau penulis puisi pasti memiliki tujuan khusus dan persembahan dalam tulisan sastra, tidak terkecuali seorang Sanusi Pane yang membuat puisi “Teratai”. Sajak Sanusi Pane “Teratai” menyimbolkan Ki Hajar Dewantara yang menjaga bumi Indonesia dengan ajarannya yang bersifat edukatif dan menyentuh aspek kebangsaan dengan semangat keindonesiaan yang murni. Puisi ini berisi peranan dan sekaligus pujian terhadap Ki Hajar Dewantara sebagai tokoh yang pantas untuk diteladani dalam hal pundidikan untuk kehidupan sepanjang hayat. Ia dibandingkan dengan bunga yang tidak menonjolkan diri namun namanya terkenal di seluruh penjuru dunia.
Kata kunci: kajian, puisi, hermeneutika, pendidikan, karakter.
Comparação da capacidade de mascaramento entre um novo dispositivo de acupuntura placebo e outros tipos de acupuntura simulada: um estudo controlado randomizado
Authors: Caetano Gleide Santos Pádua , De Souza Adnianny Almeida Simão , Santana Érika Thatyana Nascimento , Santana Mylena Maria Salgueiro , De Farias Neto Jader Pereira , Sandes Silvio Santos Lacrose , Maciel Leonardo Yung dos Santos , Da Silva Júnior Walderi Monteiro 
Published: September 2023

Introdução: Estudos têm utilizado a acupuntura placebo como forma de mascaramento para comparar a eficácia do efeito terapêutico da acupuntura. O presente estudo teve como objetivo avaliar e comparar dois métodos de acupuntura placebo como mascaramento em indivíduos saudáveis. Métodos: foram incluídos 125 indivíduos saudáveis, os quais foram divididos aleatoriamente em cinco grupos, Inserção e Retirada E36, acupuntura Real E36, dispositivo Yung Sham E36, grupo Inserção e Retirada IG4 e dispositivo Yung Sham IG4. Foi aplicada acupuntura real em um grupo e dois métodos de acupuntura placebo nos outros quatro grupos. Foi utilizado o algômetro para mensurar o limiar de dor por pressão nos indivíduos antes e após o tratamento de acupuntura. Por meio de questionário foi realizada a pergunta sobre o desconforto sentido durante o tratamento e se o sujeito acreditava se tinha recebido a acupuntura real ou placebo. Resultados: os indivíduos que foram submetidos ao dispositivo real no ponto E36 apresentaram maior crença de ter recebido o tratamento real. Quando comparado o dispositivo Yung Sham no ponto IG4 em relação ao grupo Inserção e Retirada E36, o grupo Yung Sham apresentou maior índice de mascaramento. Já o grupo Yung Sham E36 e Inserção e Retirada IG4 não apresentaram diferenças estatísticas para confirmar o mascaramento destes. Conclusão: o dispositivo Yung Sham apresentou mais eficácia no mascaramento dos sujeitos da pesquisa que foram punturados nos pontos IG4 e E36. Sendo assim o dispositivo apresenta uma certa vantagem em relação aos outros métodos placebo para utilização em futuros estudos.
Matriz de competências em educação médica: um estudo bibliométrico
Authors: Santos-Lobato Edienny Augusta Viana , Sefer Celina Cláudia Israel , De Mendonça Leonardo Teixeira , Domingues Robson José de Souza 
Published: September 2023

Na educação médica as competências oferecem uma linguagem universal compartilhada com o objetivo de definir o mínimo que se espera de um profissional de saúde para um trabalho adequado e satisfatório. Dessa forma, objetivou-se verificar e comparar os índices de publicação de artigos com elaboração de matriz de competências para a educação médica entre 2010 e 2021. Foi realizado um estudo documental bibliométrico, no qual a busca pelos trabalhos foi realizada nos bancos de dados Lilacs, Medline e repositórios digitais. O mapeamento considerou o perfil das produções, finalidade da pesquisa, área ou especialidade, se houve validação incluindo a técnica utilizada. Como resultados, obteve-se 35 artigos para análise completa, sendo a maioria publicada a partir de 2016 e na região nordeste do país, com as especialidades de medicina da família e comunidade e cardiologia com maior número de publicações. O processo de validação ocorreu predominantemente com o uso de juízes-especialistas (74%). A técnica seguindo o método de Delphi foi a mais utilizada (62%), seguida por oficinas (27,6%) e entrevistas (10,4%). A análise qualitativa do corpus textual das publicações resultou nos achados dos termos competências, medicina, matriz, residência e currículo como os mais utilizados. Desse modo, concluiu-se que a validação da matriz de competências na educação médica brasileira tornou-se uma prioridade que objetiva evitar a sobrecarga e fragmentação do ensino.
NONLINEAR DEMODULATION ALGORITHM FOR A SYSTEM BASED ON NOMA AND SPATIAL MULTIPLEXING
Authors: Крейнделин В.Б. , Варукина Л.А. 
Published: September 2023

Рассматривается задача демодуляции сигналов в системе подвижной связи, использующей комбинацию двух передовых технологий уплотнения сигналов в радиоканале — неортогональный многостанционный доступ и пространственное мультиплексирование. Предлагается новый нелинейный алгоритм демодуляции сигналов, который позволяет достичь характеристик, лучших, чем известный алгоритм с последовательным исключением помех, и приблизиться к характеристикам алгоритма максимального правдоподобия при меньшей вычислительной сложности.
A demodulation problem is a subject of this article, it refers to a mobile system implementing advanced technologies like nonorthogonal multiple access and spatial multiplexing. A proposed nonlinear demodulation algorithm is more efficient than known successive interference cancellation algorithm and gets closer to maximum likelihood efficiency at a lower complexity.
PROBLEMS OF IDENTIFICATION OF SUBSCRIBERS INITIATING VOICE CONNECTIONS IN A DATA TRANSMISSION NETWORK
Authors: Пальцин Д.А. , Фень А.С. , Горчаков А.П. , Гусев В.М. , Деарт И.Д. , Цым А.Ю. 
Published: September 2023

Сложившееся отставание нормативной базы от ряда новых сетевых сервисов обусловило необходимость безотлагательного принятия адекватных мер для обеспечения их прогрессивного развития. При этом изменения должны последовательно затронуть целый ряд действующих нормативно-технических документов. Анализируются наиболее актуальные проблемы нормативного регулирования, связанные с идентификацией абонентов, инициирующих голосовые вызовы в сети передачи данных. Это особенно важно для обеспечения безопасности функционирования сетей связи в условиях интенсивного роста телекоммуникационного трафика.
The current backlog of the regulatory framework from several new network services has necessitated an urgent and adequate solution to ensure their progressive development. At the same time, the changes should consistently affect some existing regulatory and technical documents. The most urgent problems of regulatory regulation related to the identification of subscribers initiating voice call in the data transmission network are analyzed. This is especially important for ensuring the safety of communication networks in conditions of intensive growth of telecommunication traffic.
Research on Obtaining Sintered Materials From 410 Stainless Steel Powder
Authors: BOICIUC Simona 
Published: September 2023

Ferritic steels are used in applications that require good thermal conductivity and/or durability in operation involving heat cycles. They are easy to process due to their high ductility and have magnetic properties.
The paper presents a series of experimental research on the manufacture of sintered products obtained from 410 stainless steel powder and their characterization from the microstructural and wear resistance point of view.
FACTOR ANALYSIS ON PET LOVERS INTENTION TO UTILIZE TELEMEDICINE APPLICATION FOR PETS THROUGH INTEGRATION MODEL UTAUT2 AND TPB
Authors: Margaret Fredlina , Alamsjah Firdaus , Perwira Redi Anak Agung Ngurah Perwira Redi 
Published: September 2023

The purpose of this study were to determine the factors that influence pet owners' intentions to use telemedicine applications for their pets. Based on the Unified Theory of Acceptance and Use of Technology (UTAUT2) and the Theory of Planned Behavior (TPB), in order to gather information, a survey of pet owners in Indonesia a random sampling method was used. Respondents filled out a total of 400 questionnaires, which were gathered. Using Smart Partial Least Squares (PLS) version 3.0, an analysis was done on the data that was collected. Positive factors included performance and effort expectations, attitude toward use, facilitating conditions, subjective norm, and intention to use. According to the findings, future development strategies should prioritize factors that positively influence pet owners' intentions to use telemedicine apps for pets.