bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity of temperature and precipitation characteristics to land use classification over the Taklimakan Desert and surrounding area
Authors: Li Man , Zhang Zaiyong , Ju Chenxiang , Li Huoqing 
Published: August 2023

AbstractThe Taklimakan Desert (TD) is the largest desert in China, which has a great influence on the weather and climate in the surrounding oases. To further study the impact of the unique underlying surface and artificial green space of TD on the weather and climate of the desert and its surrounding oases, we selected the winter and summer months to carry out a continuous simulation experiment using a high-resolution numerical model. The changes of land use in TD (the land use category denoted as “barren or sparsely vegetated” was modified to “shrub land”) have direct impacts on the surface heat flux, which affect the stability of the lower atmosphere and water vapor conditions, thus affected precipitation. Both sensible heat flux and latent heat flux in the desert increased in winter and summer after changing the land use type, while in areas with unchanged land use around the desert have a slight weakening in the net radiation flux. The daily temperatures increased as a whole, especially in the hinterland and south of the desert, and the warming amplitude in winter and summer was basically same. In the Kunlun Mountains, the western desert, and the oasis area to the west of the desert, the lower atmosphere became warmer and wetter, which led to a significant increase in monthly cumulative precipitation in July, with an increase in some areas greater than 36 mm which is significant for a desert area.
Improving the physicochemical and antioxidative properties of fermented goat milk using carob molasses and some probiotic strains
Authors: El-Sayed Mahmoud Ibrahim , Aly Esmat , El-Deeb Amany Mohammed 
Published: August 2023

AbstractFermented goat milk samples, processed by adding 0, 2, and 4% carob molasses, and Bifidobacterium bifidum DSMZ or Lactobacillus helveticus CH5, were evaluated for their physicochemical, antioxidative, and sensory properties along with probiotic viability during storage. pH and viscosity gradually decreased over the storage period whereas their values increased with the increased amount of carob molasses. Bifidobacterium bifidum DSMZ or Lactobacillus helveticus CH5 kept higher viable numbers. Lactobacillus helveticus CH5 strain recorded higher viability. Increasing the added amount of carob molasses increased the total phenolic content, which in turn is reflected in the increase in antioxidant activity. Adding carob molasses participated in the partial masking of the goaty flavor and had no significant effect on the product’s acceptability, which was strongly influenced by the progress of cold storage. Therefore, fermented goat milk described by its enhanced physicochemical and antioxidative properties could be obtained by adding carob molasses and probiotics.
Raman spectroscopy to discriminate laryngeal squamous cell carcinoma from non-cancerous surrounding tissue
Authors: van Lanschot Cornelia , Schut Tom Bakker , Barroso Elisa , Sewnaik Aniel , Hardillo Jose , Monserez Dominiek , Meeuwis Cees , Keereweer Stijn , de Jong Rob Baatenburg , Puppels Gerwin , Koljenović Senada 
Published: August 2023

AbstractAs for many solid cancers, laryngeal cancer is treated surgically, and adequate resection margins are critical for survival. Raman spectroscopy has the capacity to accurately differentiate between cancer and non-cancerous tissue based on their molecular composition, which has been proven in previous work. The aim of this study is to investigate whether Raman spectroscopy can be used to discriminate laryngeal cancer from surrounding non-cancerous tissue. Patients surgically treated for laryngeal cancer were included. Raman mapping experiments were performed ex vivo on resection specimens and correlated to histopathology. Water concentration analysis and CH-stretching region analysis were performed in the high wavenumber range of 2500–4000 cm−1. Thirty-four mapping experiments on 22 resection specimens were used for analysis. Both laryngeal cancer and all non-cancerous tissue structures showed high water concentrations of around 75%. Discriminative information was only found to be present in the CH-stretching region of the Raman spectra of the larynx (discriminative power of 0.87). High wavenumber region Raman spectroscopy can discriminate laryngeal cancer from non-cancerous tissue structures. Contrary to the findings for oral cavity cancer, water concentration is not a discriminating factor for laryngeal cancer.
Preanalytical variables influencing the interpretation and reporting of biological tests on blood samples of living and deceased donors for human body materials
Authors: Padalko Elizaveta , Colenbie Luc , Delforge Alain , Ectors Nadine , Guns Johan , Imbert Romain , Jansens Hilde , Pirnay Jean-Paul , Rodenbach Marie-Pierre , Van Riet Ivan , Vansteenbrugge Anne , Verbeken Gilbert , Baltes Muriel , Beele Hilde 
Published: August 2023

AbstractWith the present paper, the Working Group on Cells, Tissues and Organs and other experts of the Superior Health Council of Belgium aimed to provide stakeholders in material of human origin with advice on critical aspects of serological and nucleic acid test (NAT) testing, to improve virological safety of cell- and tissue and organ donation. The current paper focusses on a number of preanalytical variables which can be critical for any medical biology examination: (1) sampling related variables (type of samples, collection of the samples, volume of the sample, choice of specific tubes, identification of tubes), (2) variables related to transport, storage and processing of blood samples (transport, centrifugation and haemolysis, storage before and after centrifugation, use of serum versus plasma), (3) variables related to dilution (haemodilution, pooling of samples), and (4) test dependent variables (available tests and validation). Depending on the type of donor (deceased donor (heart-beating or non-heart beating) versus living donor (allogeneic, related, autologous), and the type of donated human material (cells, tissue or organs) additional factors can play a role: pre- and post-mortem sampling, conditions of sampling (e.g. morgue), haemodilution, possibility of retesting.
Consequences of gaining an extra chromosome
Authors: Torres Eduardo M. 
Published: August 2023

AbstractMistakes in chromosome segregation leading to aneuploidy are the primary cause of miscarriages in humans. Excluding sex chromosomes, viable aneuploidies in humans include trisomies of chromosomes 21, 18, or 13, which cause Down, Edwards, or Patau syndromes, respectively. While individuals with trisomy 18 or 13 die soon after birth, people with Down syndrome live to adulthood but have intellectual disabilities and are prone to multiple diseases. At the cellular level, mistakes in the segregation of a single chromosome leading to a cell losing a chromosome are lethal. In contrast, the cell that gains a chromosome can survive. Several studies support the hypothesis that gaining an extra copy of a chromosome causes gene-specific phenotypes and phenotypes independent of the identity of the genes encoded within that chromosome. The latter, referred to as aneuploidy-associated phenotypes, are the focus of this review. Among the conserved aneuploidy-associated phenotypes observed in yeast and human cells are lower viability, increased gene expression, increased protein synthesis and turnover, abnormal nuclear morphology, and altered metabolism. Notably, abnormal nuclear morphology of aneuploid cells is associated with increased metabolic demand for de novo synthesis of sphingolipids. These findings reveal important insights into the possible pathological role of aneuploidy in Down syndrome. Despite the adverse effects on cell physiology, aneuploidy is a hallmark of cancer cells. Understanding how aneuploidy affects cell physiology can reveal insights into the selective pressure that aneuploid cancer cells must overcome to support unlimited proliferation.
Emergent Phenomena in Nature: A Paradox with Theory?
Authors: van de Ven Christiaan J. F. 
Published: August 2023

AbstractThe existence of various physical phenomena stems from the concept called asymptotic emergence, that is, they seem to be exclusively reserved for certain limiting theories. Important examples are spontaneous symmetry breaking (SSB) and phase transitions: these would only occur in the classical or thermodynamic limit of underlying finite quantum systems, since for finite quantum systems, due to the uniqueness of the relevant states, such phenomena are excluded by Theory. In Nature, however, finite quantum systems describing real materials clearly exhibit such effects. In this paper we discuss these apparently “paradoxical” phenomena and outline various ideas and mechanisms that encompass both theory and reality, from physical and mathematical points of view.
gmXtal: Cooking Crystals with GROMACS
Authors: Buslaev Pavel , Groenhof Gerrit 
Published: August 2023

AbstractMolecular dynamics (MD) simulations are routinely performed of biomolecules in solution, because this is their native environment. However, the structures used in such simulations are often obtained with X-ray crystallography, which provides the atomic coordinates of the biomolecule in a crystal environment. With the advent of free electron lasers and time-resolved techniques, X-ray crystallography can now also access metastable states that are intermediates in a biochemical process. Such experiments provide additional data, which can be used, for example, to optimize MD force fields. Doing so requires that the simulation of the biomolecule is also performed in the crystal environment. However, in contrast to simulations of biomolecules in solution, setting up a crystal is challenging. In particular, because not all solvent molecules are resolved in X-ray crystallography, adding a suitable number of solvent molecules, such that the properties of the crystallographic unit cell are preserved in the simulation, can be difficult and typically is a trial-and-error based procedure requiring manual interventions. Such interventions preclude high throughput applications. To overcome this bottleneck, we introduce gmXtal, a tool for setting up crystal simulations for MD simulations with GROMACS. With the information from the protein data bank (rcsb.org) gmXtal automatically (i) builds the crystallographic unit cell; (ii) sets the protonation of titratable residues; (iii) builds missing residues that were not resolved experimentally; and (iv) adds an appropriate number of solvent molecules to the system. gmXtal is available as a standalone tool https://gitlab.com/pbuslaev/gmxtal.
Graphical Abstract
Activation of Content-Schemata for Scaffolding L2 Writing: Voices from a Turkish Context
Authors: Özgür Küfi Elmaziye 
Published: August 2023

AbstractIt has been observed that Turkish university students suffer in L2 writing when they lack background knowledge about the writing topic. Triggered by this observation, this study intended to explore effectiveness of content-schemata activation for scaffolding Turkish students in their challenging L2 writing practices. Study participants, students studying at an English-medium university in Turkey, were asked to write an essay on a specific topic at the beginning of the week before participating in any activities and then they were asked to write a second essay on the same topic after being engaged in various skills activities designed to activate their content-schemata. The same procedure was repeated for seven weeks with a different topic each week. To gather data, students’ first and second essays were compared and students’ and teachers’ perceptions regarding their experiences in English writing classes were elicited through questionnaires. As study findings reveal that content-schemata activation leads to the production of better essays in terms of content and that both students and teachers are positive about the use of skills activities for idea generation prior to essay writing, integration of activities that would activate students’ content-schemata into the language curriculum in other ESL/EFL educational contexts is highly recommended.
Scaling Family Voices and Engagement to Measure and Improve Systems Performance and Whole Child Health: Progress and Lessons from the Child and Adolescent Health Measurement Initiative
Authors: Bethell Christina D. , Wells Nora , Bergman David , Reuland Colleen , Stumbo Scott P. , Gombojav Narangerel , Simpson Lisa A. 
Published: August 2023

Abstract
Background:
The 1997 legislation authorizing the United States Child Health Insurance Program sparked progress to measure and publicly report on children’s healthcare services quality and system performance. To meet the moment, the national Child and Adolescent Health Measurement Initiative (CAHMI) public-private collaboration was launched to put families at the center of defining, measuring and using healthcare performance information to drive improved services quality and outcomes.

Methods:
Since 1996 the CAHMI followed an intentional path of collaborative action to (1) articulate shared goals for child health and advance a comprehensive, life-course and outcomes-based healthcare performance measurement and reporting framework; (2) collaborate with families, providers, payers and government agencies to specify, validate and support national, state and local use of dozens of framework aligned measures; (3) create novel public-facing digital data query, collection and reporting tools that liberate data findings for use by families, providers, advocates, policymakers, the media and researchers (Data Resource Center, Well Visit Planner); and (4) generate field building research and systems change agendas and frameworks (Prioritizing Possibilities, Engagement In Action) to catalyze prevention, flourishing and healing centered, trauma-informed, whole child and family engaged approaches, integrated systems and supportive financing and policies.

Conclusions:
Lessons call for a restored, sustainable family and community engaged measurement infrastructure, public activation campaigns, and undeterred federal, state and systems leadership that implement policies to incentivize, resource, measure and remove barriers to integrated systems of care that scale family engagement to equitably promote whole child, youth and family well-being. Population health requires effective family engagement.
Frailty and postoperative outcomes in brain tumor patients: a systematic review subdivided by tumor etiology
Authors: Qureshi Hanya M. , Tabor Joanna K. , Pickens Kiley , Lei Haoyi , Vasandani Sagar , Jalal Muhammad I. , Vetsa Shaurey , Elsamadicy Aladine , Marianayagam Neelan , Theriault Brianna C. , Fulbright Robert K. , Qin Ruihan , Yan Jiarui , Jin Lan , O’Brien Joseph , Morales-Valero Saul F. , Moliterno Jennifer 
Published: August 2023

Abstract
Purpose
Frailty has gained prominence in neurosurgical oncology, with more studies exploring its relationship to postoperative outcomes in brain tumor patients. As this body of literature continues to grow, concisely reviewing recent developments in the field is necessary. Here we provide a systematic review of frailty in brain tumor patients subdivided by tumor type, incorporating both modern frailty indices and traditional Karnofsky Performance Status (KPS) metrics.

Methods
Systematic literature review was performed using PRISMA guidelines. PubMed and Google Scholar were queried for articles related to frailty, KPS, and brain tumor outcomes. Only articles describing novel associations between frailty or KPS and primary intracranial tumors were included.

Results
After exclusion criteria, systematic review yielded 52 publications. Amongst malignant lesions, 16 studies focused on glioblastoma. Amongst benign tumors, 13 focused on meningiomas, and 6 focused on vestibular schwannomas. Seventeen studies grouped all brain tumor patients together. Seven studies incorporated both frailty indices and KPS into their analyses. Studies correlated frailty with various postoperative outcomes, including complications and mortality.

Conclusion
Our review identified several patterns of overall postsurgical outcomes reporting for patients with brain tumors and frailty. To date, reviews of frailty in patients with brain tumors have been largely limited to certain frailty indices, analyzing all patients together regardless of lesion etiology. Although this technique is beneficial in providing a general overview of frailty’s use for brain tumor patients, given each tumor pathology has its own unique etiology, this combined approach potentially neglects key nuances governing frailty’s use and prognostic value.
To Empower or Safeguard? How Novice Rape and Domestic Violence Victim Advocates Render Institutional Complexity Visible
Authors: Weiss Benjamin R. 
Published: August 2023

AbstractOrganizational life is patterned by shared meanings and practices known as “institutional logics.” Often, multiple logics exist within the same organization in a potentially tense state of “institutional complexity.” Extensive research examines how organizational elites and professionals (i.e., “experts”) manage this complexity by replacing, combining, or segregating contradictory logics. However, experts sometimes manage complexity tacitly, which obscures tensions between logics. This paper, drawing on an ethnographic study of an anti-gender-based violence organization, theorizes inexperience as a lens through which tensions become visible. Analysis of the data reveals that novice victim advocates noticed conflicts between directives to both empower and safeguard victims, practices originating from professional social work and bureaucratic state logics, respectively. In contrast, expert volunteers and staff members tacitly combined these competing logics by empowering victims to safeguard themselves. For organizational scholars, these data show how novices bring attention to contradictions that experts take for granted.
Early-stage start-up hiring: the interplay between start-ups’ initial resources and innovation orientation
Authors: Rocha Vera , Grilli Luca 
Published: August 2023

AbstractStart-up firms often operate under high levels of uncertainty and resource constraints, which makes hiring a particularly challenging process. Integrating perspectives from the resource- and competence-based views of the firm and signaling theory, we posit that founders’ start-up experience and the initial presence of corporate or university shareholders can mitigate challenges associated with hiring and facilitate the recruitment of employees in the nascent stages of a firm. Moreover, we propose that early-stage hiring will be more likely in start-ups that combine such a strong set of initial competences and resources with a strategic orientation towards innovation. We find support for our hypotheses with a rich dataset of Italian innovative start-ups.
Penalized model-based clustering of complex functional data
Authors: Pronello Nicola , Ignaccolo Rosaria , Ippoliti Luigi , Fontanella Sara 
Published: August 2023

AbstractHigh dimensional data, large-scale data, imaging and manifold data are all fostering new frontiers of statistics. These type of data are commonly considered in Functional Data Analysis where they are viewed as infinite-dimensional random vectors in a functional space. The rapid development of new technologies has generated a flow of complex data that have led to the development of new modeling strategies by scientists. In this paper, we basically deal with the problem of clustering a set of complex functional data into homogeneous groups. Working in a mixture model-based framework, we develop a flexible clustering technique achieving dimensionality reduction schemes through an$$L_1$$L1penalization. The proposed procedure results in an integrated modelling approach where shrinkage techniques are applied to enable sparse solutions in both the means and the covariance matrices of the mixture components, while preserving the underlying clustering structure. This leads to an entirely data-driven methodology suitable for simultaneous dimensionality reduction and clustering. The proposed methodology is evaluated through a Monte Carlo simulation study and an empirical analysis of real-world datasets showing different degrees of complexity.
The autumn low milk yield syndrome in Brown Swiss cows in continental climates: hypotheses and facts
Authors: Mylostyvyi Roman , Lacetera Nicola , Amadori Massimo , Sejian Veerasamy , Souza-Junior João Batista Freire , Hoffmann Gundula 
Published: August 2023

AbstractExtensive research has been conducted globally on the impact of heat stress (HS) on animal health and milk production in dairy cows. In this article, we examine the possible reasons for the decrease in milk production in Brown Swiss (BS) cows during the autumn season, known as the autumn low milk yield syndrome (ALMYS). This condition has been extensively studied in high-yielding Holstein Friesian (HF) cattle and has also been observed in BS cows with a daily milk yield of around 30 kg. Our hypothesis is that the drop in milk yield and the increased prevalence of mastitis in autumn, as found in our recent studies, may be a long-term consequence of summer HS. We re-evaluate our previous findings in light of the possible manifestation of an HS-related form of ALMYS in BS cows. As milk yield, mastitis spread, and reproductive function of cows are interrelated and have seasonal dependence, we examine the consistency of our hypothesis with existing data. The significant drop in milk yield in BS cows in autumn (by 2.0–3.2 kg), as well as the threshold of milk yield decrease (temperature-humidity index of 70.7), may point in favour of the manifestation of ALMYS in BS cows, similar to HF cows. Only the percentage effect of seasonal factor (59.4%; p < 0.05) on milk yield of BS cows was significant. HS-related ALMYS provides a robust conceptual framework for diverse sets of productive and animal health data in BS cows, similar to observations in high-yielding HF cattle. However, the limitations associated with the lack of additional data (e.g. immunological indicators) suggest the need for further research to confirm ALMYS in BS breed.
Evolutionary genomics of white spot syndrome virus
Authors: Kawato Satoshi , Omine Risako , Teruya Shinnosuke , Kubo Hirofumi , Yasumoto Shinya , Kondo Masakazu , Takahashi Yukinori , Nozaki Reiko , Kondo Hidehiro , Hirono Ikuo 
Published: August 2023

AbstractWhite spot syndrome virus (WSSV) has been one of the most devastating pathogens affecting the global shrimp industry since its initial outbreaks in Asia in the early 1990s. In this study, we recovered 13 complete metagenome-assembled genomes (MAGs) of Japanese WSSV isolates and 30 draft WSSV MAGs recovered from publicly available sequencing data, to investigate the genomic evolution of WSSV. Phylogenetic analysis revealed two major phylotypes, designated phylotypes I and II. Bayesian divergence time estimates placed the divergence time of the two phylotypes between 1970 and the early 1980s, with an estimated substitution rate of 1.1 × 10–5 substitutions per site per year, implying the existence of pre-pandemic genetic diversity of WSSV in Asia. Based on this scenario, phylotype I was responsible for the 1990s pandemic and spread worldwide, whereas phylotype II was localized in Asia and infiltrated Australia. Two cross-phylotype recombinant lineages were identified, which demonstrate the role of genomic recombination in generating the genetic diversity of WSSV. These results provide important insights into the evolution of WSSV and may help uncover the ultimate origins of this devastating pathogen.