bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left ventricular diastolic dysfunction per the 2016 ASE criteria and mortality after liver transplant in patients with end stage liver disease: a Systematic Review and Metanalysis
Authors: Martinez Carlos Eugenio Gonzalez , Regalado-Ceballos Diego , Medrano-Juárez Samantha B. , Regalado-Ceballos Airam , Padilla Isaí E. Hernández , Azpiri-López José R. , Muñoz-Espinoza Linda E. 
Published: May 2023

Abstract
Left Ventricular Diastolic Dysfunction is a hallmark of cirrhotic cardiomyopathy and has been linked to worse quality of life and outcomes in patients with end-stage liver disease. Its impact on survival after liver transplant is not known, especially using current diagnostic criteria to define LVDD. We performed a systematic review and metanalysis of current published literature on mortality after liver transplant in patients with left ventricular diastolic dysfunction. We searched for articles in PubMed, Scopus, EMBASE, Web of Science, and the COCHRANE Central database. We selected articles with adequate inclusion and exclusion criteria. Our primary outcome of interest was all cause mortality after liver transplant in relation to the presence of left ventricular diastolic dysfunction per the 2016 American Society of Echocardiography criteria. A total of 1029 articles were screened during the selection process. Two studies included in the metanalysis showed no significant difference on mortality, but heterogeneity was high. A narrative review of other studies that classified diastolic function with different criteria was also performed, finding association to worse outcomes in these patients. High quality prospective studies using current criteria are needed to corroborate these findings.
Design of good budgeting model in public division of Iran with total systems interventions (TSI) approach
Authors: Mirzadeh Leila , Azar Adel , Ghavamipour Mohsen 
Published: May 2023

Abstract
Budgeting in the public sector is an issue that numerous researchers in all countries are interested in. Therefore extensive research has been done on budgeting reforms, types, methods and models (such as, Performance-based Budgeting, Participatory Budgeting and, etc.). The present study also seeks to design a model of budgeting that provides a tool for measuring public budgeting in Iran that contain the components of Good Budgeting at each stage of the process (i.e. policy-making and formulation, implementation, approval and monitoring of the budget). Due to the complexity and extent of issues (economic, social and political) related to public budgeting, the use of new analytical methods is required for research in this field. Accordingly, the Total Systems Interventions approach (TSI) helped us to identify and select appropriate methodologies for recognizing and diagnosing the general budgeting system. Based on the results obtained from this approach, a Soft Systems Methodology (SSM) was selected to recognize the desired system. ​Consequently, Critical Systems Heuristic (CSH) and ​​​Viable System Model (VSM) were selected for its diagnosis. The combination of these methodologies in investigating the budgeting system, allowed that each of its subsystems were identified based on the VSM. Then, whit identification of the existing deficiencies, the research model was designed. Finally, this study provided a list of Good Budgeting components that were approved by experts in this field along with, suggestions for reform of the budgeting system and future research.
The statistical population of this research is experts in the field of system and budgeting in the Court of Accounts, the Plan and Budget Organization and members of the Parliament.
Data collection tools are in-depth semi-structured interviews with 16 experts.
Flexoelectricity and surface ferroelectricity in natural ice
Authors: Wen Xin , Ma Qianqian , Shen Shengping , Catalan Gustau 
Published: May 2023

Abstract

The phase diagram of ice is complex and contains many phases, but the most common (frozen water at ambient pressure, also known as 1h ice) is a non-polar material despite individual water molecules being polar themselves1,2. Consequently, ice is not piezoelectric and does not generate electricity under pressure3. On the other hand, flexoelectricity (coupling between polarization and strain gradient) is allowed by symmetry in all materials4,5, and therefore ice may polarize under bending. Here we report the measurement of the flexoelectricity of ice and calculate its repercussions for ice-electrification processes occurring in nature. In addition, the sensitivity of flexoelectricity to surface boundary conditions has revealed the existence of a ferroelectric phase transition around 163 K in the surface “skin layer” of bulk natural ice.
Rbm15 mediated m6A RNA modification participates in the regulation of AKAP2 on chondrogenesis
Authors: Peng Ke , Dai Yuliang , Lv Xin , Li Pengzhi , Lv Guohua , Wang Bing , Li Yawei 
Published: May 2023

AbstractPurpose:To investigate the function of AKAP2 in the pathogenesis of AIS by regulating the growth of chondrocyteand explore the mechanism involved.Methods:ATDC-5 cells was used as chondrogenic cell model, and the AKAP2 overexpression and knockdown plasmids were transinfected separately. The proliferation of the cells was tested with EdU and CCK-8 experiments, and the apoptosis was examined by flow cytometry. Subsequently, OE-NC and OE-AKAP2 were selected for RNA-seq and MeRIP-seq analyses to find differently expressed genes and RNA methylation peaks. . The expression of m6A methylases in OE-NC and OE-AKAP2 was then analyzed using a t-test. GSEA and KEGG enrichment analyses were performed to find out the concerning biological process and signals. The results of RNA-seq and MeRIP-seq were combined to seek the functional pathway.Results:AKAP2 knockdown significantly decreased the proliferation of ATDC-5 cells and increased the apoptosis rate, while the overexpression of AKAP2 functioned oppositely. A total of 1216 differentially expressed genes and 1193 differentially expressed peak genes were obtained in OE-AKAP2 group compared with OE-NC, and the expression of Rbm15b was significantly upregulated. Joint analysis of RNA-seq and MeRIP-seq showed that Rbm15b was significantly positively correlated with the cartilage-related gene CCN1. Moreover, GSEA and KEGG enrichment analyses showed that the WNT and NF-κB signaling pathways were significantly correlated to the overexpression of AKAP2 in ATDC-5 cells.Conclusion:Our findings suggest that AKAP2 overexpression promotes cartilage growth and development probably through upregulating Rbm15b in ATDC-5 cells and affecting the expression of CCN1, an important transcription factor in the WNT signaling pathway. This may account for the pathogenicity of AKAP2 variants in AIS to a certain degree.
Paludiculture can support biodiversity conservation in rewetted fen peatlands
Authors: Tanneberger Franziska , Martens Hanna , Laage Katha , Eickmanns Markus , Heinsohn Vincent , Wegner Nele , Muster Christoph , Diekmann Martin , Kreyling Juergen , Michalik Peter , Seeber Elke , Drexler Alexander 
Published: May 2023

Abstract
Paludiculture, the productive use of wet or rewetted peatlands, offers an option for continued land use by farmers after rewetting formerly drained peatlands, while reducing the greenhouse gas emissions from peat soils. Biodiversity conservation may benefit, but research on how biodiversity responds to paludiculture is scarce. We conducted a multi-taxon study investigating vegetation, breeding bird and arthropod diversity at six rewetted fen sites dominated by sedges (Carex species) or cattail (Typha species). Sites were either wild, low- or high-intensity managed. Biodiversity was estimated across the range of Hill numbers using the iNEXT package, and species were checked for Red List status. Here we show that paludiculture sites can provide biodiversity value even while not reflecting historic fen conditions; managed sites had high plant diversity and had Red Listed arthropods and breeding birds. Our study demonstrates that paludiculture has the potential to provide valuable habitat for species even while productive management of the land continues.
Evaluating the effect of initial soil moisture content on the infiltration characteristics using Empirical and Hydrus 1D Models
Authors: Ketela Yohannes Smeneh , Tadesse Amare , Dagalo Samuel 
Published: May 2023

Abstract

In irrigation water management, it's critical to understand the infiltration rate and its properties. The study aimed to evaluate the ability of some empirical equations and Hydrus 1D models to predict soil infiltration and evaluate the effect of initial soil moisture content on infiltration characteristics. The experiment was conducted at Arba Minch demonstration farmland using a double-ring infiltrometer, and the performance of the various infiltration models (Horton’s, Philip’s, Kostiakov, and Modified Kostiakov) and Hydrus 1D were evaluated in the study area at five different initial water contents. The results showed that the Horton and Hydrus 1D models were fitted with the observed infiltration for the soil with three initial water contents (0.13, 0.256, 0.31, 0.354, and 0.375), and the goodness of fits was evaluated by R2 and RMSE with a range between 0.9967–0.997, 0.93–0.94 and 0.0054–0.006 and 0.024, respectively. Hence, Horton and Hydrus 1D, models could be used successfully to evaluate the cumulative infiltration of soil for the study area. Therefore, in this study, the Hydrus 1D model well captured the infiltration rates at different initial soil moisture contents.
Leveraging social media to increase lung cancer screening awareness, knowledge and uptake among high-risk populations (The INSPIRE-Lung Study): Study protocol of design and methods of a community-based randomized controlled trial
Authors: Carter-Bawa Lisa , Banerjee Smita C , Ostroff Jamie S , Kale Minal S , King Jennifer C , Leopold Katherine T , Monahan Patrick O , Slaven James E , Wiener Renda Soylemez , Valenzona Francis , Rawl Susan M , Comer Robert Skipworth 
Published: May 2023

Abstract

Background.Lung cancer is the leading cause of cancer death for both men and women in the United States. The National Lung Screening Trial (NLST) demonstrated that low-dose computed tomography (LDCT) screening can reduce lung cancer mortality among high-risk individuals, but uptake of lung screening remains low. Social media platforms have the potential to reach a large number of people, including those who are at high risk for lung cancer but who may not be aware of or have access to lung screening.Methods.This paper discusses the protocol for a randomized controlled trial (RCT) that leverages FBTA to reach screening-eligible individuals in the community at large and intervene with a public-facing, tailored health communication intervention (LungTalk)to increase awareness of, and knowledge about, lung screening.Discussion.This study will provide important information to inform the ability to refine implementation processes for national population efforts to scale a public-facing health communication focused intervention using social media to increase screening uptake of appropriate, high-risk individuals.Trial Registration: The trial is registered at clinicaltrials.gov (#NCT05824273).
Functional annotation of genes associated with colonization and establishment of endophytes in Emilia sonchifolia (LINN.) DC
Authors: Urumbil Sithara K , NAIR ANILKUMAR MADHAVAN 
Published: May 2023

Abstract
Purpose The entry of rhizosheric bacteria into a plant requires efficient genomic machinery that favours its internalization into the host tissues. We hypothesize that the screening of microbial colonization genes can give an insight into the selection process where some of the soil microbes transform into endophytes in their respective host plants.Methods Total DNA was isolated from Emilia sonchifolia, PCR amplified and sequenced using Illumina Miseq method. Then metagenome assembly and gene prediction were done followed by gene functional annotation using Nr, KEGG, eggnog and CAZy databases.Results Gene functional annotations revealed the presence of genes coding for proteins involved in chemotactic movements such as cheW, cheY, che and CheR, flagellar and pilin assembly genes, genes associated with biofilm formation viz. Wza, Wzb, Wzc and WcaM, quorum sensing genes, genes associated with osmoprotectants, host defense etc.Conclusions The establishment of endophytes is a complex process and still many lacunae exist in our understanding of the process of internalization and formation of endophytes. This study confirms the presence of genes associated with colonization, internalization and penetration of endophytes in the medicinally important plant Emilia sonchifolia and thus adds to our current knowledge in plant-microbe interaction.
A rare case of Cushing’s syndrome presenting with dilated cardiomyopathy
Authors: Erdogan Beril Turan , Helvacı Burçak Cavnar , Houssein Mehdi , Postacı Nadide Aysun , Kafes Habibe , Seyrek Fatma Neslihan Çuhacı , Aydın Cevdet , Ersoy Reyhan , Topaloğlu Oya , Çakır Bekir 
Published: May 2023

Abstract
Introduction:
Cushing's syndrome (CS) is characterized by excessive cortisol production. Notably, 50% of deaths were due to cardiovascular disease. CS may associate with cardiomyopathies (CMPs), whose pathophysiology is poorly understood. We describe a patient presenting with acute heart failure and recently diagnosed with CMP who was found to have hypercortisolism secondary to an adrenal adenoma.
Case:
A 31-year-old male patient was admitted to the cardiology department due to dyspnea. He had a weight gain of 25 in the last year. His blood pressure was 135/85 mmHg, and his pulse rate was 102bpm. He had central obesity (body mass index: 31 kg/m2), buffalo hump, and abdominal purple-blue wide striae. Transthoracic echocardiography revealed global hypokinesia [left ventricle end-diastolic diameter of 6 cm/m2 (normal range < 3.2 cm/m2) on M-mode], and 20%of LVEF (standard: 50–70%). Laboratory evaluation revealed increased plasma cortisol levels with an absence of circadian rhythm. Serum cortisol levels were not suppressed after the overnight 1 mg and two-day low-dose dexamethasone suppression test (LDDST). The hormonal evaluation indicated ACTH-independent CS (Table-1). Magnetic-resonance imaging of the adrenal gland revealed a 37x28mm adenoma in the lateral limb of the left adrenal gland. The patient was diagnosed with CS. Metyrapone was used to reduce cortisol levels before the surgery. The plasma cortisol level decreased to 14.8 µg/dL on the 20th day of metyrapone treatment. Although the ejection fraction of the left ventricle was still 40% on echocardiography (Table-2), improvement of heart failure symptoms was achieved (New York Heart Association (NYHA) class II). After reducing plasma cortisol levels and improving the EF, he underwent a successful left adrenalectomy procedure. Clinical and laboratory findings improved significantly soon after surgery. The pathology result was reported as diffuse nodular hyperplasia. The patient's LVEF was 50% at the 6th month follow-up and > 60% at the 1st year follow-up.
Conclusion:
CS CMP is a reversible entity induced by hypercortisolism. It is characterized by cell hypertrophy, myofibrillolysis, and myocardial fibrosis that revert after adrenalectomy. In addition, preoperative anesthesia risk may increase due to low LVEF because of the CMP. Therefore, patients may need to be treated preoperatively with rapid-acting adrenolytic drugs.
Complex spatiotemporal dynamics in a network of locally and magnetically coupled VDPCL oscillators
Authors: TEGNITSAP Joakim Vianney NGAMSA , KENGNE Romanic , NKENGFACK Laurent Chanel DJOUFACK , FOTSIN Hilaire Bertrand 
Published: May 2023

AbstractNowadays, we are witnessing a dramatic advance in wireless technology-based magnetic induction. It is used both for wireless power transfer and data transfer between systems. In addition, it is widely shown that a network of coupled identical oscillators exhibits complex collective behavior characterized by the coexistence of coherent and incoherent domains and termed as chimera state. In this paper, we consider a network of (N≥10) locally and magnetically coupled Van der Pol oscillators coupled to a linear circuit (VDPCL oscillators). We then investigate the different arrangements of their interactions in terms of the magnetic coupling coefficients, taken as the bifurcation parameters. Statistical measure namely the strength of incoherence is used to classify the synchronized states in the network. Another algorithm described in the text is used for the classification and is consistent with the strength of incoherence. Numerical simulation reveals that the emerging spatiotemporal behaviors depend on the choice of initial conditions revealing the presence of multistability in the network. This network configuration also reveals a rich repertoire of spatiotemporal dynamics such as coherence/global synchronization, decoherence, chimera state, cluster synchronization, and solitary states as the magnetic coupling coefficients vary. Some other interesting behaviors such as traveling clustered wave, double and multicluster chimera state, and clustered solitary state for a specific set of initial conditions are also obtained. Furthermore, Pspice-based simulations carried out for a network of (N=10) oscillators are consistent with the numerical simulations based on the mathematical model.
Synthesis, characterization and non-isothermal degradation kinetics of rosebengal end capped Poly(aniline)/Cr2O3 nanocomposite
Authors: Ramasamy Anbarasan , Mary M. Kenet Nancy , Jancirani A. , Baskaran R. 
Published: May 2023

Abstract

Solution polymerization of aniline was carried out in the presence of peroxydisulphate as a radical initiator under N2atmosphere at 0-5oC for 2 hours both in the presence and absence of Cr2O3(bulk)material under vigorous stirring condition. During the polymerization reaction the rosebengal (RB) dye was added as an end capping agent. The above synthesized polymers were characterized by FT-IR, UV-visible, fluorescence emission, XPS, XRD, DSC, TGA, SEM, HR-TEM, viscosity and conductivity measurements. The added Cr2O3(bulk)controlled the structure of Poly(aniline) (PANI) and the same can be confirmed by FT-IR spectroscopy. The Tgof Cr2O3medicated poly(aniline) showed somewhat higher value than the pristine PANI. The XPS showed the presence of Cr3d2p3/2and Cr3d2p1/2peaks and this confirmed the nano-sized crystalline Cr2O3. Further, its thermal degradation was studied by non-isothermal degradation kinetics and their thermodynamic parameters were determined. The experimental data was compared with the available literature data.
Mesh-Container Plasty in advanced painful osteolytic vertebral metastases with posterior wall defect：a retrospective observational study
Authors: Liu Qingshan , Li Dingding , He Yuanliang , Lei Xi , Yan Jun , Feng Wei , He Chengchui , Huang Xuemei , Cao Dan , Dong Yingchun 
Published: May 2023

Abstract
Background：
Percutaneous vertebroplasty for deficient posterior wall of metastatic vertebrae lead to high rate of bone cement leakage. In order to improve the safety, MCP, a new technique improved based on PVP, has been developed to control the dispersion of bone cement.
Objective:
To evaluate the efficacy and safety of Mesh-Container Plasty (MCP) in patients suffering advanced vertebral metastases with deficient posterior wall.
Patients and methods:
111 patients were retrospectively included from January 2014 to January 2018 in our hospital. These patients were divided into two groups, group MCP (n=51) and group PVP (n=60). According to the percentage of the area of posterior wall defect as the total area of posterior wall, the patients of both groups were originally classified into four grades, grade I≤25%, grade II 26%-50%, grade III 51%-75%, grade IV 76%-100%. Visual analog scale (VAS) and Oswestry disability index (ODI) were applied to compare the efficacy before and after MCP and PVP. Minor and major complications were systematically recorded to measure the safety.
Results：
Both groups experienced significant pain relief and improvement of motor function after MCP and PVP. Pre-op and post-op VAS and ODI at any time point during follow-up did not present significant difference between MCP and PVP (P > 0.05). In MCP, 13 cases presented bone cement leakage, with the leakage rate of 25.49%. None of the patients developed any clinical or neurological symptoms. In PVP, 50% of the patients occurred bone cement leakage. Six patients developed neurological symptoms. major complications between two groups presented significant difference for bone cement leakage (P=0.03).
Conclusion:
In conclusion, MCP is able to significantly relieve pain and improve the safety in treating vertebral metastases with deficient posterior wall. It provides a better option for spinal surgeon to treat vertebral metastases with posterior wall deficiency.
Features &amp; Data Graphs of Hospitalisation Fever: A Case in Teaching Medical Centres
Authors: H Frank (D.C.) 
Published: May 2023

Abstract
I. BACKGROUND
The understanding of hospitalization fever remains limited. Improving care could be facilitated by considering specific diseases associated with fevers, as indicated by ICD9 codes in admission or discharge notes.
II. METHODS
We conducted an analysis using data from Taipei Medical University Hospital, examining 59,772 inpatient admissions and 425,488 nights of stay annually between 2007 and 2009. Decision tree and rule induction techniques were employed to characterize fever-related diseases during hospitalization. Association rules were generated to suggest and validate comorbidities beyond those related to fever.
III. CONCLUSIONS
Throughout the three-year period, fever consistently ranked as the most frequent ICD9 code in inpatient health records, including admission and discharge notes, accounting for over 25% of the top six most common codes. Our study illustrated the diseases associated with fever and their comorbidities. Notably, 81.193% of fever-related ICD9 codes occurred fewer than 14 times, and the association rules for fever-related comorbidities improved care with a 48.077% coverage rate through appropriate CPOE implementation.
A DFT-Based Investigation of the properties of gold nanoclusters up to Au20
Authors: Kargar Ali , Mohammadnejad Sima 
Published: May 2023

AbstractThe structures and stabilities of gold clusters with up to 20 atoms have been studied by Density Functional Theory (DFT) and compared in two vacuum and COSMO environment here for the first time. The structure optimizations and frequency analysis are performed with the Generalized Gradient Approximation (GGA) BLYP (Becke, 1988; Lee et al., 1988) functional in Dmol3combined with the all-electron relativistic core treatment and corresponding Double Numerical plus Polarization (DNP) basis set. The transition point from two-dimensional to three-dimensional geometry for gold clusters occurs at Au17in both the vacuum and COSMO environment. The structural, energetic, and electronic properties of the small gold clusters strongly depend on sizes and structures, which are in good agreement with other theoretical and experimental calculations. It was also found that the effect of relativistic properties has a great influence on the properties of gold clusters. The even-odd oscillation (saw-tooth patterns) observed in the different properties of the clusters predicts the stability of the clusters and their electronic properties. The result shows that the clusters with even numbers of atoms were more stable than the neighboring clusters with odd numbers of atoms due to their closed-shell orbital structure. Also, the properties of gold nanoclusters in COSMO seem to be different from the vacuum environment.