bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Study of QoS on Video Meeting Tool Application in 4G LTE Network using Wireshark
Authors: Sirmayanti Sirmayanti , Tain Asriani , Hamzidah Nurul Khaerani 
Published: January 2023

Video meeting is a broadband internet-based service for long-distance communication, both visual and audio, in one room or in different rooms at the same time. Network testing using wireshark software connects to the Telkomsel operator's 4G LTE network. QoS parameters can display network quality such as throughput, packet loss, delay and jitter. The research experiment test used two conditions with different variables in the five types of video meeting tools being compared; zoho meeting, cisco webex meeting, google meet, zoom meeting and microsoft teams. First-condition uses random variables that do not consider the value of the number of participants and camera & microphone conditions to each client. Second-condition uses a fixed variable that the number of each client is 5 participants for each application (camera & microphone is on). The first-condition results showed that only Zoom Meeting which had a QoS value classified as Poor (index 1), especially the jitter value, compared to other applications. This application has an average jitter of 151,871 ms, that compared to TIPHON standard of 125 ms to 255 ms. The second-condition obtained Very Good QoS on throughput, packet loss and delay variables in all applications. Their variable jitter in each application is Zoho Meeting (0.101 ms), Cisco Webex meeting (0.074 ms), Google Meet (0.179 ms), Zoom meeting (0.021 ms), and Microsoft Teams (0.015 ms) which only in the standard 0 ms to/ d 75 ms. However, all applications according to the TIPHON standards are still in the Good category (index 3). The overall index average of all applications shows Good QoS.Keywords: video meeting, wireshark, quality of service, 4G LTE.
Inisiasi menyusu dini (IMD) sebagai upaya awal pemberian ASI eksklusif: scoping review
Authors: Nidaa Izzatun , Hadi Ella Nurlaela 
Published: January 2023

Latar belakang: ASI merupakan makanan terbaik bagi bayi yang dapat mendukung tumbuh kembang dan kesehatan bayi. Terdapat berbagai manfaat dari ASI dan ASI eksklusif bagi bayi dan masa depannya. Salah satu faktor yang mempengaruhi keberhasilan ASI eksklusif adalah inisiasi menyusu dini (IMD). Tujuan penelitian: Tujuan dari tinjauan literatur ini adalah untuk mengidentifikasi bukti-bukti yang tersedia dari literatur terkini terkait hubungan IMD dan ASI eksklusif. Metode: Tinjauan literatur ini menggunakan metode scoping review, dengan tahapan mengidentifikasi pertanyaan penelitian, mengidentifikasi artikel yang relevan, menyeleksi artikel, memetakan data serta menyusun, meringkas, dan melaporkan hasil. Hasil: Dari hasil seleksi akhir, didapatkan 18 artikel yang sesuai. Sebanyak 17 artikel menggunakan desain penelitian kuantitatif dan 1 artikel menggunakan mix method. Lokasi penelitian termasuk beberapa negara yaitu China, Jepang, Indonesia, India, Sri Lanka, Arab Saudi, Ethiopia, Nigeria, dan beberapa negara di Afrika lainnya. Sebagian besar artikel menunjukkan adanya hubungan antara IMD dan ASI eksklusif. Simpulan: IMD merupakan faktor yang mempengaruhi ASI eksklusif. IMD setelah persalinan diperlukan sebagai upaya untuk melanjutkan keberlangsungan pemberian ASI ekslusif hingga enam bulan.
Self efficacy dan dukungan suami terhadap pemeriksaan IVA pada PUS di Desa Sugihan Kabupaten Lamongan
Authors: Utami Aris Puji , Hidayati Nur 
Published: January 2023

Latar belakang: Pemeriksaan Ispeksi Visual Asam Asetat (IVA) salah satu metode deteksi dini kanker serviks yang efektif di negara berkembang, namun rendahnya keyakinan dan dukungan sumai terhadap pemeriksaan IVA membuat pemeriksaan ini tidak sesuai dengan target program. Tujuan penelitian: Diketahuinya pengaruh self efficacy dan dukungan suami terhadap pemeriksaan IVA Pada PUS di Desa Sugihan Kabupaten Lamongan. Metode : Desain penelitian menggunakan analitik dengan pendekatan cross sectional. Populasi semua Pasangan Usia Subur (PUS) yang berkunjung di Posyandu Tulip Desa Sugihan pada tanggal 08 Juli 2022. Jumlah sampel 37 PUS yang diambil dengan simple random sampling. Data yang digunakan adalah data primer dengan metode wawancara terstruktur. Instrumen menggunakan kuesioner. Data dianalisis dengan menggunakan uji Chi Square dengan tingkat kesalahan (ɑ = 0,05). Hasil: Sebagian besar PUS di di Desa Sugihan Kabupaten Lamongan tidak yakin terhadap pemeriksaan IVA dan tidak mendapat dukungan dari suami untuk melakukan pemeriksaan IVA . Sebagian besar PUS di Desa Sugihan Kabupaten Lamongan tidak melakukan pemeriksaan IVA. Hasil uji chi square menunjukkan nilai signifikan kurang dari α=0,05. Simpulan: Ada pengaruh self efficacy dan dukungan suami terhadap pemeriksaan IVA .
PHSYCHOMETRIC PROPERTIES INDONESIAN STROKE RECOGNITION QUESTIONNAIRE (SRQ) UNTUK PASIEN DENGAN HIPERTENSI, DIABETES MELLITUS, DAN PENYAKIT JANTUNG
Authors: Nursiswati Nursiswati , Maniatunufus Maniatunufus , Kurnia Herliani Yusshy 
Published: January 2023

Pengetahuan dan pengakuan yang dibutuhkan untuk stroke dapat diterapkan dalam pelayanan klinis maupun dalam penelitian. Pengetahuan tentang gejala stroke penting agar individu dapat mengambil tindakan dengan cepat untuk mendapatkan intervensi yang efektif dan mengurangi kecacatan dan kematian akibat stroke. Salah satu instrumen yang sering digunakan untuk mengidentifikasi pengetahuan tentang faktor risiko dan gejala stroke adalah Stroke Recognition Questionnaire (SRQ). Psychometric properties mengacu pada validitas dan reliabilitas sebuah instrument pengukuran. Tujuan Penelitian ini adalah untuk mengidentifikasi validitas dan reliabilitas SRQ versi Indonesia. Sample penelitian adalah klien dengan diabetes melitus, hipertensi dan penyakit jantung sebanyak 30 orang responden di salah satu rumah sakit di Provinsi Banten. SRQ original version diterjemahkan back dan forward, lalu dilakukan uji konten oleh expert, uji face validity oleh responden dan uji contruct validity dan uji reliability. Hasil uji validitas SRQ pada seluruh pernyataan gejala stroke dan bukan gejala stroke serta pada pernyataan faktor risiko dan bukan faktor risiko stroke dinyatakan valid karena seluruh item pernyataan mempunyai nilai r_hitung diatas r_tabel yaitu diatas 0,361. Hasil uji reliabilitas SRQ mempunyai nilai Cronbach’s Alpha pada gejala dan bukan gejala stroke yaitu 0,819 dan 0,755 serta pada faktor risiko dan bukan faktor risiko stroke yaitu 0,719 dan 0,649 yang berarti instrumen dinyatakan reliabel dalam penelitian ini.SRQ versi Indonesia.
Kata Kunci: Stroke, faktor resiko, tanda, gejala, SRQ
HUBUNGAN KUALITAS TIDUR DENGAN KESIAPAN MENGIKUTI PROSES BELAJAR MAHASISWA STIKES PONDOK PESANTREN ASSANADIYAH PALEMBANG TAHUN 2021
Authors: Prautami Erike Septa , Dewi Ratna 
Published: January 2023

Tujuan: Untuk mengetahui Hubungan Kualitas tidur dengan Kesiapan Mengikuti Proses Belajar Mahasiswa STIKES Pondok Pesantren Assanadiyah Palembang.
Metode: Penelitian ini merupakan penelitian survei analitik dengan menggunakan desain cross sectional dengan pendekatan kuantitatif. Teknik sampling adalah Total Sampling yaitu seluruh mahasiswa STIKES Pondok Pesantren Assanadiyah Palembang yang berjumlah 30 orang.
Hasil: dari hasil penelitian didapatkan ada 24 responden yang memiliki kualitas tidur baik dengan hasil 17 responden memiliki kesiapan belajar baik dan 7 responden memiliki kesiapan belajar kurang baik. Sementara itu, ada 6 responden yang memiliki kualitas tidur buruk, 2 responden diantaranya memiliki kesiapan belajar baik dan 4 responden lainnya memiliki kesiapan belajar kurang baik. Berdasarkan uji statistik dengan menggunakan uji Chi Square diperoleh nilai p value = 0,038 (p value ≤ 0,05), artinya diterima.
Simpulan: Terdapat hubungan antara kualitas tidur dengan kesiapan mengikuti proses belajar mahasiswa STIKES Pondok Pesantren Assanadiyah Palembang .
Kata Kunci: kualitas tidur, kesiapan belajar, mahasiswa
Pengembangan Sistem Informasi Manajemen Penginapan & Homestay Pada Palmyra Homestay Malang
Authors: Prasetyo Koko Wahyu , Dewantara Rizky Galuh 
Published: January 2023

Teknologi informasi memiliki kontribusi penting pada peningkatan kinerja di sektor industri pelayanan (hospitality). Faktor-faktor yang mempengaruhi peningkatan kinerja tersebut di antaranya adalah optimasi sumber daya dan peningkatan mutu pengalaman pelanggan. Palmyra Homestay Malang selama ini melakukan aktivitas manajemen ketersediaan kamar secara manual. Efisiensi aktivitas tersebut dapat ditingkatkan lebih lanjut dengan adanya aplikasi system informasi yang mengintegrasikan seluruh pemangku kepentingan yang terkait. Penelitian ini akan mengembangkan sebuah aplikasi sistem informasi berbasis web dan android yang memiliki beberapa fitur fungsional antara lain: pengelolaan data reservasi, manajemen kamar, transaksi keuangan, dan pelaporan status housekeeping. Metode pengembangan apliakasi yang digunakan dalam penelitian ini adalah metode waterfall yang meliputi analisis kebutuhan, perancangan sistem, pengkodean program, uji coba program, dan penerapan program. Metode Blackbox Testing digunakan untuk menguji aplikasi dengan berfokus pada fungsionalitas untuk memastikan input dan ouput aplikasi sesuai dengan yang dibutuhkan. Luaran dari penelitian ini diharapkan dapat mempermudah pihak manajemen hotel dalam melakukan aktivitas bisnisnya.
Ethanolic Extract of Hedysarum Alpinum L Is Rich in Flavonoids and Shows Free Radical Scavenging and Psychological Modulation Activities
Authors: Jalsrai Aldarmaa , Urtnasan Myadagbadam , Hsieh-Li Hsiu Mei 
Published: January 2023

Hedysarum alpinum L (HA) is reported to be able to support the immune and nervous systems. However, there is only a few reports about the pharmacological activity of this plant. In current study, we investigated the phytochemical and pharmacological properties of an extract of HA using in vitro and iv vivo models. An extract of the specimens preserved in 70% ethanol was filtered and vacuum dried. Established conventional methods were used for quantitative determination of total phenolic and flavonoids content. Phytochemical characterization showed gallic acid, rutin, and quercetin are rich in the ethanolic extract of HA. In addition, the extract showed free radical scavenging activity on hydroxyl and lipid radicals with IC50 6.72 and 7.73 mg/ml, respectively. Furthermore, in vivo studies were performed on rats with orally applying the HA extract and then assessed their psychological behaviors in elevated plus maze (EPM) and open-field tasks. The HA extract exhibited psychological modulation activity. Our study suggests the ethanolic extract of HA could be potential to be used in the products of mood soother.
CMAR and extent of compliance with IFRS 101 standard among Malaysian ace market companies
Authors: Lode Nor Asma 
Published: January 2023

Malaysia is on the track to achieve full convergence and adoption of the International
Financial Reporting Standards (IFRSs) by 2012. This study seeks to find out the extent
of compliance with IFRS 101 â€˜P
resentation of Financial Statementsâ€™ before the effective
date. Using total disclosure index (TDI), the findings shows that most of Malaysian Ace
Market companies have complied with IFRS 101. The present study also indicates that
the Cumulative Market Adju
sted Return (CMAR) is positive and significant for both
partial and full compliance of IFRS 101 among the Malaysian Ace Market companies.
Multivariate regression analysis further provides a lack of significant association
between CMAR and announcement of e
arnings (i.e. EPS). Nevertheless, the percentage
of independent directors on the board (BDIND) is found to be a positive and a significant
corporate governance variable that associates with CMAR. These findings imply that
policy makers and regulators shoul
d encourage Ace Market companies to have the
most optimal number of independent board of directors for future improvements of
CMAR
Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate
Authors: Efe Jem A. , Botelho Roberto , Emr Scott D. 
Published: January 2023

<p>The lipid kinase Fab1 governs yeast vacuole homeostasis by generating PtdIns(3,5)P(2) on the vacuolar membrane. Recruitment of effector proteins by the phospholipid ensures precise regulation of vacuole morphology and function. Cells lacking the effector Atg18p have enlarged vacuoles and high PtdIns(3,5)P(2) levels. Although Atg18 colocalizes with Fab1p, it likely does not directly interact with Fab1p, as deletion of either kinase activator-VAC7 or VAC14-is epistatic to atg18Delta: atg18Deltavac7Delta cells have no detectable PtdIns(3,5)P(2). Moreover, a 2xAtg18 (tandem fusion) construct localizes to the vacuole membrane in the absence of PtdIns(3,5)P(2), but requires Vac7p for recruitment. Like the endosomal PtdIns(3)P effector EEA1, Atg18 membrane binding may require a protein component. When the lipid requirement is bypassed by fusing Atg18 to ALP, a vacuolar transmembrane protein, vac14Delta vacuoles regain normal morphology. Rescue is independent of PtdIns(3,5)P(2), as mutation of the phospholipid-binding site in Atg18 does not prevent vacuole fission and properly regulates Fab1p activity. Finally, the vacuole-specific type-V myosin adapter Vac17p interacts with Atg18p, perhaps mediating cytoskeletal attachment during retrograde transport. Atg18p is likely a PtdIns(3,5)P(2)"sensor," acting as an effector to remodel membranes as well as regulating its synthesis via feedback that might involve Vac7p.</p>
<p> </p>
PENGEMBANGAN MEDIA CREDIPUP UNTUK PESERTA DIDIK SEKOLAH DASAR
Authors: Elisa Rozzana , Nugroho Arya Setya , Subayani Nataria Wahyuning 
Published: January 2023

Tujuan penelitian ini adalah untuk mengembangkan media Credipup dalam pembelajaran Ilmu Pengetahuan Sosial guna meningkatkan minat belajar peserta didik kelas 6 MI Muhammadiyah 2 Banyuurip. Penelitian pengembangan ini menggunakan model ADDIE (Analysis, Design, Development, Implementation, Evaluation) hasil modifikasi menurut Branch. Instrumen pengumpulan data menggunakan lembar wawancara, lembar validasi, dan angket respon. Dalam penelitian ini menggunakan dua teknik analisis data, yaitu analisis hasil validasi untuk mengetahui kevalidan media dan analisis hasil angket untuk mengetahui keefektifan media dalam meningkatkan minat belajar. Hasil penelitian menunjukkan bahwa hasil validasi media Credipup pada aspek kelayakan isi 88,57% dengan kategori sangat valid, pada aspek kelayakan kebahasaan 73,3% dengan kategori valid, dan aspek kelayakan kegrafikan 77% dengan kategori valid. Hasil angket respon peserta didik kelas 6 pada pembelajaran pertama mencapai 81%, pada pembelajaran kedua 78,8%, dan pada pembelajaran ketiga mencapai 81,66%. Hasil rekapitulasi angket respon diperoleh rata-rata persentase skor yang mencapai 80,49% %, sehingga media Credipup dikategorikan valid dan efektif dalam meningkatkan minat belajar peserta didik.
Case report: Clinical characteristics of two cases of pneumonia caused with different strains of Chlamydia psittaci
Authors: Wang Zheng , Chen Chen , Lu Hu , Wang Li , Gao Lin , Zhang Jing , Zhu Chi , Du Furong , Cui Lunbiao , Tan Yan 
Published: January 2023

BackgroundWith the development of metagenomic sequencing technologies, more and more cases of pneumonia caused with Chlamydia psittaci (C. psittaci) have been reported. However, it remains unknown about the characteristics of patients with pneumonia caused by different strains of C. psittaci. Here, we shared the clinical characteristics of two cases of pneumonia caused with C. psittaci strains SZ18-2 and SZ15 which were rarely identified in humans.Case presentationCase 1: A 69-year-old male farmer who fed ducks presented to hospital for cough, diarrhea and lethargy with the temperature of 39.8°C. Case 2: A 48-year-old male worker who slaughtered ducks was transferred to hospital for high fever, cough, myalgia, diarrhea and loss of appetite. Both patients did not take any protective measures (wearing face masks or gloves) while processing ducks. C. psittaci pneumonia was diagnosed by metagenomic next-generation sequencing and polymerase chain reaction. After treatment with doxycycline and azithromycin individually, they recovered well and discharged from hospital. Through OmpA sequencing, two different strains of SZ18-2 and SZ15 were identified in case 1 and case 2, respectively.ConclusionsPatients infected with different strains of C. psittaci may own different clinical manifestations. C. psittaci infection should be suspected when pneumonia appears, accompanied by digestive symptoms and multiple organ dysfunction, especially under the exposure of specific birds.
Identification of hub genes and pathways of ferroptosis in Fusarium keratitis by bioinformatics methods
Authors: Teng Xingbo , Xiong Xuewei , Sha Xiaoyuan , Lei Yahui , Diao Yuyao , Liu Jiayan , Tian Yuan , Liu Lian , Zhong Jingxiang 
Published: January 2023

BackgroundFungal keratitis is a common blinding eye disease, and Fusarium is one of the main species that cause fungal keratitis. As is well known, oxidative stress plays an important role in Fusarium keratitis and it is also a significant initiating factor of ferroptosis. But the relationship between Fusarium keratitis and ferroptosis is currently unclear. This study aimed to speculate and validate potential ferroptosis-related genes in Fusarium keratitis using bioinformatics analysis, which provided ideas for further research on its specific mechanism and new targets for its treatment. MethodsThe microarray expression profiling dataset (GSE58291) came from Gene Expression Omnibus (GEO). The differentially expressed genes (DEGs) were obtained by the limma package of the R software. The DEGs were performed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Then, the DEGs were intersected with the genes in the ferroptosis database. The top 5 hub genes were obtained by the protein-protein interaction (PPI) network analysis and the cytoHubba plug-in of Cytoscape software. The hub genes were subjected to GSEA analysis. Then we analyzed the immune infiltration of the samples by CIBERSORT and ssGSEA algorithm. Finally, we validated the mRNA of hub genes by qPCR.ResultsA total of 1,368 DEGs were identified and 26 ferroptosis-related DEGs were obtained. At the same time, ferroptosis-related pathways were enriched by GO and KEGG using DEGs. HMOX1, CYBB, GPX2, ALOX5 and SRC were obtained by the PPI network analysis and the cytoHubba plug-in of Cytoscape software. The iron metabolism and immune response related pathways were enriched using GSEA. They included hematopoietic cell lineage, lysosome and FC gamma R mediated phagocytosis. T cells follicular helper, monocytes, macrophages and mast cells might play an important role in Fusarium keratitis using analysis of immune infiltration. Finally, qPCR confirmed that the expression of HMOX1, CYBB, ALOX5 mRNA in the DON group was significantly elevated, while the expression of GPX2 were significantly decreased.ConclusionsFerroptosis may play an important role in Fusarium keratitis. HMOX1, CYBB, ALOX5 and GPX2 may be key ferroptosis-related genes in the pathogenesis of Fusarium keratitis.
Water deprivation induces hypoactivity in rats independently of oxytocin receptor signaling at the central amygdala
Authors: Felintro Viviane , Trujillo Verónica , dos-Santos Raoni C. , da Silva-Almeida Claudio , Reis Luís C. , Rocha Fábio F. , Mecawi André S. 
Published: January 2023

IntroductionVasopressin (AVP) and oxytocin (OXT) are neuropeptides produced by magnocellular neurons (MCNs) of the hypothalamus and secreted through neurohypophysis to defend mammals against dehydration. It was recently demonstrated that MCNs also project to limbic structures, modulating several behavioral responses.Methods and ResultsWe found that 24 h of water deprivation (WD) or salt loading (SL) did not change exploration or anxiety-like behaviors in the elevated plus maze (EPM) test. However, rats deprived of water for 48 h showed reduced exploration of open field and the closed arms of EPM, indicating hypoactivity during night time. We evaluated mRNA expression of glutamate decarboxylase 1 (Gad1), vesicular glutamate transporter 2 (Slc17a6), AVP (Avpr1a) and OXT (Oxtr) receptors in the lateral habenula (LHb), basolateral (BLA) and central (CeA) amygdala after 48 h of WD or SL. WD, but not SL, increased Oxtr mRNA expression in the CeA. Bilateral pharmacological inhibition of OXTR function in the CeA with the OXTR antagonist L-371,257 was performed to evaluate its possible role in regulating the EPM exploration or water intake induced by WD. The blockade of OXTR in the CeA did not reverse the hypoactivity response in the EPM, nor did it change water intake induced in 48-h water-deprived rats.DiscussionWe found that WD modulates exploratory activity in rats, but this response is not mediated by oxytocin receptor signaling to the CeA, despite the upregulated Oxtr mRNA expression in that structure after WD for 48 h.
Predicting the risk of autoimmune thyroid disease in patients with vitiligo: Development and assessment of a new predictive nomogram
Authors: Ma Ze , Cai Menghan , Yang Kang , Liu Junru , Guo Tao , Liu Xiaojie , Zhang Junling 
Published: January 2023

BackgroundThis study aimed to develop an autoimmune thyroid disease (AITD) risk prediction model for patients with vitiligo based on readily available characteristics.MethodsA retrospective analysis was conducted on the clinical characteristics, demographics, skin lesions, and laboratory test results of patients with vitiligo. To develop a model to predict the risk of AITD, the Least Absolute Shrinkage and Selection Operator (LASSO) method was used to optimize feature selection, and logistic regression analysis was used to select further features. The C-index, Hosmer–Lemeshow test, and decision curve analysis were used to evaluate the calibration, discrimination ability and clinical utility of the model. Internally, the model was verified using bootstrapping; externally, two independent cohorts were used to confirm model accuracy.ResultsSex, vitiligo type, family history of AITD, family history of other autoimmune disease, thyroid nodules or tumors, negative emotions, skin involvement exceeding 5% of body surface area, and positive immune serology (IgA, IgG, IgM, C3, and C4) were predictors of AITD in the prediction nomogram. The model showed good calibration and discrimination (C-index: 0.746; 95% confidence interval: 0.701–0.792). The accuracy of this predictive model was 74.6%.In both internal validation (a C-index of 1000 times) and external validation, the C-index outperformed (0.732, 0.869, and 0.777). The decision curve showed that the AITD nomogram had a good guiding role in clinical practice.ConclusionThe novel AITD nomogram effectively evaluated the risk of AITD in patients with vitiligo.