bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphate Adsorption on Cerium/Terephthalic Acid Metal–Organic Frameworks (Ce‐MOF) Driven by Effective Electrostatic Attraction and Ligand Exchange in a Wide pH Range
Authors: Zhou Zhenyu , Li Dexuan , Huang Weiming , Wang Rongyue , Zhong Jiapeng , Zhang Yangyang , Meng Jiazhou , Li Chuanhao 
Published: May 2023

AbstractEutrophication has posed a threat to aquatic ecosystems, so it's urgent to remove excessive phosphate from water. In this study, we developed an adsorbent material, cerium/terephthalic‐acid metal‐organic‐frameworks (Ce‐MOF), to remove phosphate from different water systems. The optimal Ce‐MOF presented a maximum phosphate adsorption capacity of 377.2 mg/g, approximately 3.7 times higher than that of the commercial phosphate adsorbent (Phoslock: 101.6 mg/g). Experimental and computational analysis suggested that pH dominated the adsorption process. The main forces driving the adsorption process changed from the synergistic effect of electrostatic attraction and ligand exchange at lower pH to only ligand exchange at the increased pH values. Hence, the Ce‐MOF is applicable for phosphate adsorption in a wide pH range. Impressively, the adsorbent remained an excellent phosphate adsorption performance in the real water containing various interfering ions and organic matters, indicating the potential of Ce‐MOF for the practical use to solve the water eutrophication issue.
Evaluation of the reboot coaching workshops among urology trainees: A mixed method approach
Authors: Al‐Ghunaim Tmam , Johnson Judith , Biyani Chandra Shekhar , Coleman Rebecca , Simms‐Ellis Ruth , O'Connor Daryl B. 
Published: May 2023

AbstractBackgroundUrology trainees experience high burnout, and there is an urgent need for acceptable and effective interventions. The current study evaluated Reboot coaching workshops (Reboot‐C), a tailored intervention based on cognitive–behavioural principles, with urology trainees.ObjectiveOur primary objective was to evaluate the acceptability of Reboot‐C among urology trainees. In addition, this study aimed to investigate whether there were changes in confidence, resilience, depression and burnout levels.Materials and methodA single‐arm design was used, including pre‐ and post‐online questionnaires and semi‐structured interviews.ResultTwenty‐one urology trainees replied to the survey, attended both Reboot‐C workshops and responded to the post‐intervention questionnaire. Thirteen of 21 (61%) urology trainees participated in the interview. Participating in Reboot‐C was associated with significant improvements in resilience and confidence and a significant reduction in burnout. However, there was no significant reduction in depression. Qualitative data indicated that Reboot was acceptable and helped participants develop useful skills.ConclusionThese findings pave the way for more conclusive studies on the efficacy of Reboot‐C for surgeons.
Implementing a differential reinforcement of low rates schedule to alter vocal stereotypy and task engagement in two adolescents with autism spectrum disorder
Authors: Mantzoros Theoni , Lee David L. , Ajemigbitse Ashley R. , Stover Laura J. 
Published: May 2023

AbstractVocal stereotypy (VS) is often observed in individuals with autism spectrum disorder (ASD) which at high rates can interfere with socialization or functioning in structured settings. There are multiple effective interventions available; yet, many procedures target the complete omission of the behavior or are only assessed at short intervals, making it unclear how they will generalize in applied settings. One intervention yet to be assessed as an individual intervention for automatically reinforced VS is differential reinforcement of low rates of behavior (DRL). In the present study, a functional analysis determined that the VS of two female adolescents with ASD was maintained by automatic reinforcement. A DRL procedure was implemented which incorporated: (a) a specified interval for reinforcement; (b) the behavioral expectations; (c) the permissible instances of VS within the interval; (d) learner feedback; and (e) the reset/non‐reset aspect of the schedule. As the targeted behavior decreased across sessions, the DRL interval was systematically increased in order to thin out the schedule of reinforcement. The intervention reduced VS and increased untargeted task engagement for both participants. Applied and theoretical implications of the study as well as social validity, limitations, and future research are discussed.
Virtual screening of carboxylic acid reductases for biocatalytic synthesis of 6‐aminocaproic acid and 1,6‐hexamethylenediamine
Authors: Shi Kun , Li Ju‐Mou , Zhang Zhi‐Jun , Chen Qi , Xu Jian‐He , Yu Hui‐Lei 
Published: May 2023

AbstractThe key precursors for nylon synthesis, that is, 6‐aminocaproic acid (6‐ACA) and 1,6‐hexamethylenediamine (HMD), are produced from petroleum‐based feedstocks. A sustainable biocatalytic alternative method from bio‐based adipic acid has been demonstrated recently. However, the low efficiency and specificity of carboxylic acid reductases (CARs) used in the process hampers its further application. Herein, we describe a highly accurate protein structure prediction‐based virtual screening method for the discovery of new CARs, which relies on near attack conformation frequency and the Rosetta Energy Score. Through virtual screening and functional detection, five new CARs were selected, each with a broad substrate scope and the highest activities toward various di‐ and ω‐aminated carboxylic acids. Compared with the reported CARs, KiCAR was highly specific with regard to adipic acid without detectable activity to 6‐ACA, indicating a potential for 6‐ACA biosynthesis. In addition, MabCAR3 had a lower Km with regard to 6‐ACA than the previously validated CAR MAB4714, resulting in twice conversion in the enzymatic cascade synthesis of HMD. The present work highlights the use of structure‐based virtual screening for the rapid discovery of pertinent new biocatalysts.
Preoperative symptoms of depression, anxiety, and cognitive impairment in glioma patients: A cerebral perfusion CT study
Authors: Wang Ke , Fu Wanrui , Li Shenjie , Chen Lizhen , Gan Yajie , Xiang Wei , Chen Ligang , Zhou Jie 
Published: May 2023

AbstractPurposeGlioma patients have varying degrees of psychiatric symptoms, which severely affect the quality of life of patients and their families. The present study investigated the correlation between preoperative psychiatric symptoms and local cerebral perfusion parameters of in glioma patients.Patients and methodsThe depression, anxiety, and cognitive impairment (CI) scores of 39 patients were assessed separately, and all of the patients underwent a preoperative perfusion computed tomography scan.ResultsThis study found that: (1) The incidence of preoperative symptoms of depression, anxiety, and CI was 46.15%, 48.72%, and 25.64%, respectively. (2) Cerebral blood volume (CBV) (lesion‐sided [LS] occipital lobe white matter [WM] and parietal lobe WM and normal‐sided temporal lobe WM), permeability surface (PS) (LS temporal lobe gray matter [GM] and parietal lobe WM) in the depression group were significantly decreased (p < .05). (3) CBV (LS occipital lobe WM), cerebral blood flow (LS parietal lobe GM, centrum ovale and frontal lobe WM and normal‐sided frontal lobe WM, temporal lobe WM and parietal lobe WM), and mean transition time (MTT) (normal‐sided frontal lobe WM and temporal lobe WM) in the anxiety group were significantly increased (p < .05). (4) CBV (LS temporal lobe GM), MTT (LS anterior limb of internal capsule), and PS (LS thalamus) in the CI group were significantly increased (p < .05).ConclusionThis study showed that glioma patients had different levels of psychological distress in glioma patients before surgery, which may be related to the changes in brain perfusion caused by the tumor.
Clinical features of ischemic stroke in patients with nonvalvular atrial fibrillation combined with intracranial atherosclerotic stenosis
Authors: Wu Ning , Wang Xinli , Jia Shuai , Cui Xiaomei , Wang Yaozhen , Li Jian , Zhang Xiaojun , Wang Yanqiang 
Published: May 2023

AbstractBackgroundNonvalvular atrial fibrillation (NVAF) and intracranial atherosclerotic stenosis (ICAS) are major causes of ischemic stroke. Relatively few studies have focused on the risk factors and clinical features of ischemic stroke caused by NVAF combined with ICAS.MethodWe retrospectively evaluated NVAF and/or ICAS in patients with acute ischemic stroke admitted within 72 h after stroke. All patients with acute ischemic stroke underwent diffusion‐weighted magnetic resonance imaging (DWI), magnetic resonance angiography (MRA), computed tomography angiography (CTA), and/or digital subtraction angiography (DSA). NVAF was detected by routine electrocardiogram or 24‐h Holter examination, Doppler echocardiography, and contrast echocardiography of the right heart.ResultsAmong the 635 enrolled patients, NVAF, ICAS, and NVAF+ICAS were diagnosed in 170 (26.77%), 255 (40.16%), and 210 (33.07%) patients, respectively. Patients in the NVAF+ICAS group were older (p < .001), specifically aged ≥75 years (p < .001). The admission time of the NVAF+ICAS group was shorter (p < .001) than that of the ICAS group. The admission NIHSS score of the NVAF group was higher than that of the NVAF+ICAS group (p < .001). HsCRP, NTpro‐BNP, and LEVF levels were significantly different among the three groups (p < .001). NVAF+ICAS ischemic stroke occurred mainly in the right hemisphere (52.4%).ConclusionNVAF with ICAS ischemic stroke is more likely to occur in older patients. Infarctions occurred mainly in the right cerebral hemisphere. Neurological deficits in NVAF are more severe than those in NVAF combined with ICAS and in simple ICAS ischemic strokes. HsCRP, LEVF, andNTpro‐BNP seem to be closely associated with NVAF+ICAS ischemic stroke.
Like a shot‐through manubrium: A rare presentation of skeletal tuberculosis
Authors: Fujiwara Tomohiro , Yanai Hiroyuki , Hagiya Hideharu 
Published: May 2023

AbstractA 22‐year‐old Vietnamese woman presented with anterior chest swelling. Computed tomography revealed an osteolytic lesion in the manubrium, whereas MRI showed an extra‐osseous expansion. A needle biopsy showed granuloma formation, whereas a 3‐week mycobacterial culture indicated Mycobacterium tuberculosis infection. Manubrium/sternum involvement in tuberculosis is extremely rare but should be considered.
A rare case of soft tissue sarcoma in the supraclavicular region: A case report
Authors: Kato Ronald , Kibudde Solomon , Mwondha Yusuf , Farah Starlin 
Published: May 2023

AbstractSarcomas of the head and neck account for about 2% of all head and neck malignancies in adults. The median age at diagnosis is 50–54 years with a slight male predominance. The rarity of these sarcomas and lack of prospective trials make it difficult to reach valid conclusions. A 36‐year‐old woman was referred to our hospital because of an expanding non‐pulsatile mass in the right supraclavicular fossa with associated numbness and paresthesia of the right forearm. The patient reported that the mass had gradually enlarged for the past 5 months. She had no history of trauma or any chronic illnesses. A physical examination revealed a mass measuring approximately 7 cm × 5 cm above the right clavicle with no palpable thrill or bruit. Ultrasound‐guided biopsy was done and the histology report revealed soft tissue cells, fatty cells, and skeletal muscle cells; no tumor cells were identified. Magnetic resonance angiogram studies were made and revealed a highly vascularized supraclavicular mass. Under a multidisciplinary approach, the mass was resected. Head and neck sarcomas are relatively rare tumors and those of the head and neck account for about 2% of all head and neck malignancies and 4%–10% of all sarcomas in adults. The main histologic subtypes are rhabdomyosarcoma, osteosarcoma, chondrosarcoma, and angiosarcoma.
Persistent level 1 hypoglycemia due to hypothyroidism and underlying Neurofibromatosis type 1
Authors: Nguyen Hoang , Nguyen Quynh Thu , Thet Zeyar , Hoang Thanh D. 
Published: May 2023

Key Clinical MessageHypoglycemia in non‐diabetic patients is rare and may be due to various etiologies. It is important to recognize hypoglycemia early and appropriately manage hypoglycemia in patients with neurofibromatosis 1 and hypothyroidism.AbstractNon‐diabetic hypoglycemia is not common and can be seen in certain conditions like Neurofibromatosis type 1 (NF1). We report a rare case of 66‐year‐old man with hypothyroidism and NF1 who developed a persistent level 1 hypoglycemia.
A difficult case of Hodgkin lymphoma mimicking tuberculosis in a young female patient: A case report
Authors: Roumi Jamal Bakri , Farho Mohamad Ali , Hariri Mohamad Moafak , Khoury Abdullah 
Published: May 2023

Key Clinical MessageDue to overlapping clinical symptoms, it may be difficult to distinguish between Hodgkin lymphoma and tuberculosis. Repeated investigations, especially biopsy and histopathological examination, may be helpful to establish a correct diagnosis. Herein, we present a case of Hodgkin's lymphoma misdiagnosed as tuberculosis so we always need evidence‐based medicine in our medical life.AbstractDistinguishing between Hodgkin's Lymphoma and tuberculosis is challenging. A 23‐year‐old patient has been diagnosed with tuberculosis; based on clinical and radiological findings. After the therapy, her condition worsened. Cervical lymphadenopathy was detected. A biopsy was performed and the diagnosis was classical Hodgkin lymphoma. After the treatment, the patient improved significantly.
Temporal lobe hemorrhage as a complication of HSV encephalitis: a case report
Authors: Rijal Ashes , Chaudhary Sharmila , Shah Sangam , Itani Asmita , Suryabanshi Anil , Thapa Sangharsha 
Published: May 2023

Key Clinical MessageThis case underlined the importance of having high suspicion for lobar hemorrhage as a rare but deadly complication of herpes simplex virus encephalitis and shone light upon the added complexity it poses on management on an already deadly disease.AbstractHerpes simplex virus (HSV) encephalitis is the most common type of sporadic encephalitis that inflicts high rates of morbidity and mortality. Differentiating a progressing encephalitis syndrome from a lobar hemorrhage as a complication presents a challenge and requires great vigilance and insight on part of the treating physician.
Pembrolizumab induced pericardial tamponade: A case report
Authors: Uczkowski Dariusz , Ashraf Hamza , Sekhri Arunabh , Samad Arbaz 
Published: May 2023

Key Clinical MessageThe occurrence of a large pericardial effusion is not a commonly noted adverse event associated with pembrolizumab and our report demonstrates that a rapid development can be diagnosed with close monitoring and triage to acute medical settings.AbstractPembrolizumab is an immune checkpoint inhibitor used in various types of cancers. Pericardial tamponade is a rare side effect reported in only very few case reports. Early recognition and therapeutic intervention is vital in all cases. We report a case of a 54‐year‐old male with Stage 3 lung adenocarcinoma who developed cardiac tamponade secondary to pembrolizumab and subsequently required pericardial window.
Direct and transfer hydrogenation of furfural over MOF‐derived Pd‐Cu@C catalysts
Authors: Xia Xinxin , Gao Yuxin , Li Pei , Fu Mengyao , Zhu Lingyi , Li Cuiqin , Li Feng 
Published: May 2023

AbstractOwing to the self‐reducing ability of palladium acetate in solutions, an ethanol solution containing Pd0 particles was prepared and coated in‐situ into copper metal–organic framework (Cu‐MOF), forming Pd@Cu‐MOF in a coated structure. The Pd@Cu‐MOF was reduced under N2 or H2 to form carbon‐coated Pd‐Cu@C. The pyrolysis and carbonization of Cu‐MOF and the reduction of Cu2+ were studied. The Cu‐MOF under either N2 or H2 was pyrolyzed and carbonized, but the Cu2+ reduction mechanisms were different. The high‐temperature carbothermic reduction of Cu2+ under N2 produced Cu0, but during low‐temperature reduction under H2, the reducing H2 reduced Cu2+ to Cu0. Furfural hydrogenation experiments showed that compared with H2, the Pd‐Cu@C prepared under N2 reduction displayed higher furfural hydrogenation activity. The catalytic activity of Pd‐Cu@C prepared from in‐situ Pd0 coating was higher than the Pd/Cu@C prepared from the impregnation method. With i‐propanol as the solvent, the catalytic hydrogenation of furfural under H2 consisted of direct catalytic hydrogenation with molecular hydrogen as the hydrogen source and catalytic transfer hydrogenation with i‐propanol as the hydrogen donor. The catalytic activity of direct catalytic hydrogenation is higher than the catalytic transfer hydrogenation.
An Indium Synthetic Etioporphyrin for Organic Electronics: Aggregation and Photoconductivity in Thin Films
Authors: Koifman Oskar I. , Rychikhina Ekaterina D. , Travkin Vlad V. , Sachkov Yury I. , Stuzhin Pavel A. , Somov Nikolay V. , Yunin Pavel A. , Zhabanov Yuriy A. , Pakhomov Georgy L. 
Published: May 2023

AbstractA new complex of indium(III)chloride with etioporphyrin‐I was synthesized and characterized. As with naturally occurring extraligated etioporphyrins, the InCl‐EtioP−I spectrum in solution has a very strong B‐band and a more than an order of magnitude weaker Q‐band, but this difference diminishes in solid films of InCl‐EtioP−I obtained by thermal evaporation in vacuum. In a solid, molecules have a tight convex‐convex arrangement in a 2D double layered structure with interplane distance of 3.066 Å. The conductivity of films can easily be activated by the action of temperature or light. In the cells with symmetrical lateral contacts the photocurrent exceeds the dark current by about three orders of magnitude, with the contribution of photons in the Q‐band range being greater than expected from the experimental or calculated absorption spectrum. The Q‐bands contribute significantly to the photovoltaic effect in the ITO/InCl‐EtioP−I/Al sandwich cells. Such cells show an untypically strong signal in the photodiode regime, which yields the spectral detectivity of 10^12 Jones.
Reducing the generation time in winter wheat cultivars using speed breeding
Authors: Schoen Adam , Wallace Sydney , Holbert Meghan Fisher , Brown‐Guidera Gina , Harrison Stephen , Murphy Paul , Sanantonio Nicholas , Van Sanford David , Boyles Richard , Mergoum Mohamed , Rawat Nidhi , Tiwari Vijay 
Published: May 2023

AbstractReducing generation time is critical to achieving the goals of genetic gain in important crops like wheat (Triticum aestivum). Speed breeding (SB) has been shown to considerably reduce generation times in crop plants. Unlike spring wheat cultivars, winter wheat varieties require typically 6–9 weeks of cold treatment, called vernalization, for flowering which extends the generation time for the development of improved winter wheat cultivars. Here, we optimized the SB method using a set of 48 diverse soft red winter wheat (SRWW) cultivars by testing vernalization duration, light and temperature requirements, and the viability of seeds harvested after different durations post‐anthesis under extended daylight conditions. We have found that using a 22‐h setting (22 h day/2 h night, 25°C/22°C) in high‐density 50‐cell trays results in rapid generation advancement. We used genotypic data for a panel of soft red winter wheat varieties from the regional programs to determine the impact of photoperiod and vernalization alleles on the efficiency of the SB approach. Using a set of 48 SRWW cultivars and germplasm from Maryland and four other public breeding programs, we establish that this protocol can allow for the advancement of four generations per year in controlled conditions for winter wheat varieties, experimental lines, or emerging cultivars. Our work shows the potential to reduce generation time by ∼30 days per generation faster than what had been reported in the SB strategies for winter wheat, thus allowing for a quicker turnaround time from original cross to genetically stable experimental genotypes that can be tested in field settings.
Effect of Temperature and H Flux on the NH3 Synthesis via Electrochemical Hydrogen Permeation
Authors: Ripepi Davide , Schreuders Herman , Mulder Fokko M. 
Published: May 2023

AbstractAmmonia is an indispensable commodity and a potential carbon free energy carrier. The use of H permeable electrodes to synthesize ammonia from N2, water and electricity, provides a promising alternative to the fossil fuel based Haber‐Bosch process. Here, H permeable Ni electrodes are investigated in the operating temperature range 25–120 °C, and varying the rate of electrochemical atomic hydrogen permeation. At 120 °C, a steady reaction is achieved for over 12 h with 10 times higher cumulative NH3 production and almost 40‐fold increase in faradaic efficiency compared to room temperature experiments. NH3 is formed with a cell potential of 1.4 V, corresponding to a minimum electrical energy investment of 6.6 kWh kg−1
. The stable operation is attributed to a balanced control over the population of N, NHx and H species at the catalyst surface. These findings extend the understanding on the mechanisms involved in the nitrogen reduction reaction and may facilitate the development of an efficient green ammonia synthesis process.
High school quality is associated with cognition 58 years later
Authors: Seblova Dominika , Eng Chloe , Avila‐Rieger Justina F. , Dworkin Jordan D. , Peters Kelly , Lapham Susan , Zahodne Laura B. , Chapman Benjamin , Prescott Carol A. , Gruenewald Tara L. , Arpawong Thalida Em. , Gatz Margaret , Jones Rich J. , Glymour Maria M. , Manly Jennifer J. 
Published: May 2023

AbstractWe leveraged a unique school‐based longitudinal cohort—the Project Talent Aging Study—to examine whether attending higher quality schools is associated with cognitive performance among older adults in the United States (mean age = 74.8). Participants (n = 2,289) completed telephone neurocognitive testing. Six indicators of high school quality, reported by principals at the time of schooling, were predictors of respondents’ cognitive function 58 years later. To account for school‐clustering, multilevel linear and logistic models were applied. We found that attending schools with a higher number of teachers with graduate training was the clearest predictor of later‐life cognition, and school quality mattered especially for language abilities. Importantly, Black respondents (n = 239; 10.5 percentage) were disproportionately exposed to low quality high schools. Therefore, increased investment in schools, especially those that serve Black children, could be a powerful strategy to improve later life cognitive health among older adults in the United States.