bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-cadherin expression – Significance in gastric carcinoma
Authors: J Divya , R Prathipaa 
Published: July 2023

Gastric carcinoma is aggressive cancer with poor prognosis. E-cadherin is 120 kD calcium mediated transmembrane glycoprotein that forms the cell adhesion molecule which maintains the integrity of epithelial cells by keeping it cohesive. E-cadherin down regulation in gastric cancer is of great significance in the dissociation of epithelial cells, alteration of tumor microenvironment, invasion, tumor genesis and metastasis. To study the E-cadherin expression in gastric carcinoma and to correlate with the existing clinical and pathological parameters.The study included 100 confirmed cases of adenocarcinoma from gastrectomy specimens. Immunostaining was done with E-cadherin mouse monoclonal antibody and expression studied based on the staining pattern and correlated with various clinico-pathological parameters. Data was statistically analysed by chi square test with calculation of p-value.E-cadherin expression showed aberrant staining in 87% cases. E-cadherin expression showed significant correlation with histological types, tumor grade, tumor depth of invasion, lymphovascular invasion and lymphnode involvement. The expression E-cadherin in gastric cancer was aberrant in 100 % of diffuse type and poorly differentiated tumors. 96.61% of lymph node positive cases showed aberrant expression. The cases with aberrant expression were comparatively more in T3 (100%) and T4 (93.75%) tumors.The study highlights the significance of E-cadherin expression in gastric carcinoma that can be utilised as a potent bio marker for aggressiveness, metastasis and prognosis.
Factors affecting the severity of COVID-19 and the development of complications
Authors: Radygina Lubov V. , Mochalova Larisa V. 
Published: July 2023

ABSTRACT
Due to the prevalence and diversity of both symptoms and outcomes of COVID-19, understanding the factors that determine the risk of the severe course of this disease and its possible complications is of particular importance. In this review, we present the information on the specifics of COVID-19 pathogenesis and give a theoretical justification for the factors that determine the course of this disease in patients of different age groups, patients with chronic pathology, and pregnant women. Particular attention is paid to the post-COVID syndrome.
Visual Inferential Elements in EFL Learning in Mbujimayi
Authors: DIKELELA KAPINGA Désiré , CIBANGU MBAYA Patrice , KABUYI KAHAMBA Patrick 
Published: July 2023

The paper focuses on some inferential elements in EFL learning in Mbujimayi. More specifically, the study points out differences occurring in English sound production of /t/, /dʒ/, /ʒ/, /ð/, /v/, and /θ/ by Ciluba speaking learners. After discussing the findings obtained from observation and questionnaire, it has been discovered that the learners’ prior linguistic knowledge justifies the errors they make in this regard, the linguistic patterns of the target language being unfamiliar to them. To remedy the issue, we suggest three things: (1) attention, implying that the teacher should work to make the learners recognize words so that they can be aware of them as useful language items. (2) Retrieval, standing for the process indicating that a word may be noticed by the learners and understood in the textual input to the task. (3) Generation, which implies requiring of the learners to use the wanted item in new contexts.
UNIVERSITIES – A NEW WAY FOR DEVELOPMENT
Authors: TERZIEV Venelın 
Published: July 2023

This research analyses the role of universities as a driving force of development, as part of a developing high-tech society that sets different standards and focus areas. The reversed top-down direction with the set requirements and criteria for growth gave university education and science a high formalism, which is expressed in self-sufficient academic growth, not particularly effective project funding and untapped potential for society.
European and national policies in the field of education and science are being analyzed, which are expected to generate ideas and new models for development, form new focus areas and positions that will not reflect everyday life in the system, but will look years ahead. Reforming universities has long been on the agenda mainly, but not only, due to changes in the social environment, in the economy, in technologies, in risks and pandemics. Universities are the ones that “produce” human resources for the leadership of the state, for the management and maintenance of each system.
This work attempts to discuss knowledge sharing as part of the Open Science movement. It attempts to briefly analyse its historical development and the options for modern implementation of the open science idea. It discusses the process of knowledge sharing as an element of recognition of scientific works and part of social development. It seeks a solution to the established national and other restrictions for sharing of knowledge, as well as its importance in the situation of limited sharing. The article also discusses the process of changes in the higher education system in Bulgaria related to the consolidation of Bulgarian universities
Kepraktisan Buku Ilmiah Populer Botani Tumbuhan Rawa Dalam Melatihkan Keterampilan Berpikir Kritis Mahasiswa
Authors: Dharmono Dharmono , Utami Nurul Hidayati , Sari Mella Mutika 
Published: July 2023

Researches on the development of teaching materials in universities in the learning process to Improving higher-order thinking in plant Botany courses based on local materials are currently very necessary. Various forms of teaching materials were developed to Improving critical thinking skills. One of them is a popular scientific book. This study aims to test the practicality of the popular scientific book (BIP) Botany of Swamp Plants in improving students' critical thinking skills in studying Higher Plant Botany. The type of research was Research and Development (R&D). The research subjects were 13 students of the Biology Education Study Program at Lambung Mangkurat University, with the object of research being BIP Botany of Swamp Plants. Practicality data was obtained based on the readability tests of three students, and 10 students. The research data were analyzed descriptively. The results showed that the BIP Botany of Swamp Plants which was developed practically (very practical category) was used to improve students' critical thinking skills.
HUBUNGAN PERSEPSI TERHADAP PERILAKU PENCEGAHAN AKNE VULGARIS PADA SISWA SMA
Authors: Sihombing Anggeta Daniella , Djamahar Refirman , Sartono Nurmasari 
Published: July 2023

Abstrak
Akne vulgaris merupakan sebuah kelainan multifaktorial pada unit pilosebasea yang dengan tingkat keparahan terjadi pada saat usia 15-18 tahun dengan persentase 85-100% selama hidup. Pencegahan akne vulgaris sangat dibutuhkan guna meminimalkan terbentuknya akne vulgaris. Perilaku pencegahan dapat muncul dari sebuah persepsi. Persepsi ialah sebuat stimulus yang berasal dari luar dan diinterpretasikan untuk memberikan arti bagi lingkungannya. Tujuan penelitian ini ialah guna mengetahui hubungan persepsi terhadap perilaku pencegahan akne vulgaris pada siswa SMA. Penelitian dilaksanakan di SMAN 36 Jakarta pada semester genap bulan Januari-Februari 2021. Metode penelitian yang diterapkan ialah metode deskriptif dengan studi korelasional menggunakan regresi korelasi sederhana. Hasil penelitian mengungkapkan bahwa terdapat hubungan positif dan signifikan persepsi terhadap perilaku pencegahan akne vulgaris, dimana 0,292% variabel persepsi memberikan kontribusi terhadap perilaku pencegahan akne vulgaris.
Kara kunci: Persepsi, Perilaku pencegahan, Akne vulgaris
Abstract
Acne vulgaris is a multifactorial disorder in pilosebaceous units that with severity occurs at the age of 15-18 years with a percentage of 85-100% during life. Prevention of acne vulgaris is needed to minimize the formation of acne vulgaris. Preventive behavior can arise from perception. Perception is a stimulus that comes from the outside and is interpreted to give meaning to the environment. Therefore, this study aims to determine the relationship of perception to the prevention behavior of acne vulgaris in high school students. This research was conducted at SMAN 36 Jakarta on the 2nd semester, from January until February 2021. The method of this research was the descriptive method with correlational studies using simple correlation regression analysis. The results revealed that there was a positive and significant relationship of perception to the prevention behavior of acne vulgaris, where 0.292% of perception variables contributed to the prevention behavior of acne vulgaris.
Keywords: Perception, Preventive behavior, Acne vulgaris
Pengembangan Handout Biologi Berbasis Pendekatan Kontekstual Pada Materi Biologi: Studi Literatur
Authors: Ramadhani Rosi , Rahmi Yosi Laila , Fitri Rahmadhani , Selaras Ganda Hijrah 
Published: July 2023

Penggunaan bahan ajar dalam proses pembelajaran yang tepat dapat meningkatkan pemahaman, minat, serta motivasi pesera didik untuk belajar. Banyak hal yang bisa dilakukan oleh guru membantu peserta didik dalam mencapai hasil belajar yang lebih baik, salah satunya adalah pengembangan materi pendidikan seperti handout. Handout yang berdasarkan pendekatan kontekstual merupakan salah satu bahan ajar yang dapat mengaktifkan peserta didik memahami materi biologi. Penelitian ini bertujuan untuk menghasilkan handout valid yang berbasis pendekatan kontekstual pada materi biologi. Penelitian ini merupakan pengembangan dengan model pengembangan 4-D yang terdiri dari langkah-langkah mendefinisikan, merancang, mengembangkan, dan menyebarluaskan. Metode yang digunakan dalam penelitian ini adalah meta analisis dari studi literatur. Hasil dari pengembangan ini adalah menghasilkan handout berdasarkan kriteria sangat valid dan sangat praktis.
Decreasing incidence of CKD/CKDu in North Central Province of Sri Lanka: is it related to provision of drinking water reverse osmosis plants?
Authors: Ranasinghe Asanga , Somatunga Lakshmi , Kumara Priyantha , Karunarathna Ranamuka , De Silva Pubudu , Gunawardena Chathurika , Kumari Champika , Sarjana Fathima , De Silva Chandu 
Published: July 2023

Abstract
Background
We assess the impact of provision of reverse osmosis (RO) water on the incidence of CKD/CKDu in North Central Province (NCP) of Sri Lanka.
Methods
A cross sectional survey was conducted on data from 2010–2020 on the incidence of CKD/CKDu, CKD/CKDu screening and provision of drinking water reverse osmosis (RO) plants in NCP. Analysis was conducted using descriptive statistics, ANOVA and chi-square test.
Results
The incidence of CKD/CKDu (per 100 000 population) in 2010–2013, 2014–2016 and 2017–2020 periods in Anuradhapura district were 129.07, 331.06 and 185.57 (p = 0.002) while in Polonnaruwa district these were 149.29, 326.12 and 296.73 (p = 0.04) respectively. In NCP provision of Reverse Osmosis (RO) plants commenced after 2011 and the decline in the incidence of CKD/CKDu occurred in 25 of the 29 Divisional Secretary Divisions when more than 20% of the families received access to drinking RO water projects. In both districts mean time taken to reduce the incidence rate of CKD/CKDu after reaching 20% of family coverage is 0.8 years.
Conclusions
CKD/CKDu incidence increased in NCP from 2010 to 2016 and continuously decreased thereafter. Continuous declining of CKD/CKDu incidence was observed after more than 20% of the families received access to drinking water RO plants.
The mediating effects of coping styles in the relationship between dyadic adjustment and maternal postpartum depression: a cross-sectional study
Authors: Deng Jing , Chen Jing , Guo Xiujing , Liu Fan 
Published: July 2023

Abstract
Background: Postpartum depression (PPD) is a major psychological matter following childbirth and may be correlated to detrimental effect for the mother, spouse, infants, and children. The risk factors for PPD among postpartum women have been studied, and yet the mechanisms of these factors are still imprecise. This study aimed to examine the direct and mediating effects of different coping styles in the relationship between the dyadic adjustment and PPD among postpartum women.
Methods: A cross-sectional study was administered to 626 delivery women who have been given birth in a tertiary hospital. Sociodemographic and obstetric data were measured by a self-developed questionnaire. The Dyadic Adjustment Scale (DAS), Simplified Coping Style Questionnaire (SCSQ), and Edinburgh Postnatal Depression Scale (EPDS) were performed to measure the marital adaptation status, coping styles, and depressive symptoms of postpartum women, respectively. Furthermore, the direct and mediating effects analysis was conducted using structural equation modeling.
Results: The prevalence of PPD was 22.6% in this study. The standardized path coefficients from the dimensions of dyadic adjustment to PPD (Dyadic consensus: β=﹣0.16, P﹤0.01, Affectional expression: β=﹣0.14, P﹤0.01, Dyadic cohesion: β=﹣0.10, P﹤0.05) achieved significance but Dyadic satisfaction (β=﹣0.06, P=0.19). Positive coping styles played a mediating role in the effect of Dyadic consensus and Dyadic satisfaction on EPDS (95% CI: − 0.036, −0.001, P﹤0.05; 95% CI: − 0.081, −0.008, P﹤0.05, respectively), negative coping style played a mediating role in the effect of Dyadic satisfaction and Dyadic cohesion on EPDS (95% CI: −0.111, −0.025, P﹤0.05; 95% CI: −0.139, −0.044, P=0.001, respectively).
Conclusion: Higher level of marital quality diluted the likelihood of PPD directly as well as indirectly through the mediating roles of coping styles. Thusly, ameliorating the quality and adjustment status of marital, employing positive coping style at once could assist to improve maternalpsychological health.
Cohort Profile: Iranian Electronic Physiology Registry (IEPR)
Authors: Nikoo Mohammad Hossein , Jorat Mohammad Vahid , Heydari Seyed Taghi , Mostafavi Sara , Fatemian Hossein , Zamani Mohammad Mohsen , Aghabozorgi Mahan , Jafari Mohammad Bagher , Karami Mohammad , Mahmoudi Masoud , Mohammadi Sina , Rahimi Maede , Yazdanpanah Reza , Kalantari Mohammad , Falahi Mohammad Reza , Jafary Ida , Namazee Mehrad , Arjangzade Alireza , Emkanjoo Zahra , Nikoo Amir Ali 
Published: July 2023

Abstract
Objective: Cardiac Implantable Electronic Devices have emerged as an important treatment modality in the field of electrophysiology. The use of cardiac devices including pacemakers, implantable cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy (CRT), has increased significantly over the past few decades. The long-term outcomes of these devices need to be investigated.
Data description: The Iranian Electronic Physiology Registry (IEPR) will identify factors that may predispose patients to complications, long-term outcomes of cardiac devices, hospitalizations, and mortality rates.
FLEX PUF: A Flexible Physical Unclonable Function Design Using Configurable Templates
Authors: Vega Christopher , SLPSK Patanjali , Chatterjee Atri , Bhunia Swarup 
Published: July 2023

Abstract

Field Programmable Gate Array (FPGA) has been seen as the intersection between cost and design time when compared to ASIC and DSP. Many of the security risks present in the supply chain apply to FPGA devices, and as such, there exists a need for FPGA-based security measures. Physically Unclonable Functions (PUFs) have shown to be a promising method for authenticating and validating devices. Current works have utilized FPGAs as a method for testing ASIC PUFs or do not utilize the FPGA architecture to the benefit of the PUF, limiting its potential application.
In this work, we propose an FPGA-based PUF that takes advantage of the FPGA architecture to increase entropy. We propose a PUF that utilizes different design templates to switch out the method of entropy used to generate the PUF response. We also propose using the routing and placement constraints to further increase the entropy generated. By doing so, we can create a hybrid, strong memory-based PUF, where the placement, routing, and templates act as input challenges.
To evaluate our PUF, we analyze the responses provided by a set of different templates to evaluate their uniqueness, robustness, and uniformity. Additionally, we evaluate the entropy provided by the templates and compare it to other templates and when mapped to different areas of the FPGA. We also evaluate the security benefits of our system and provide techniques for better leveraging the performance of our PUF.
Dithiine-linked Metalphthalocyanine Framework with Undulated Layers for Highly Efficient and Stable H2O2 Electroproduction
Authors: Jiang Jianzhuang , zhi qianjun , Jiang Rong , Yang Xiya , Jin Yucheng , Qi Dongdong , Wang Kang 
Published: July 2023

Abstract
Realization of stable and industrial-level H2O2 electroproduction still faces great challenge due large partly to the easy decomposition of H2O2. Herein, a two-dimensional dithiine-linked phthalocyaninato cobalt (CoPc)-based covalent organic framework (COF), CoPc-S-COF, was afforded from the reaction of hexadecafluorophthalocyaninato cobalt (II) with 1,2,4,5-benzenetetrathiol. Introduction of the sulfur atoms with large atomic radius and two lone-pairs of electrons in the C-S-C linking unit leads to an undulated layered structure and an increased electron density of the Co center for CoPc-S-COF according to a series of experiments in combination with theoretical calculations. The former structural effect allows the exposition of more Co sites to enhance the COF catalytic performance, while the latter electronic effect activates the 2e- oxygen reduction reaction (2e- ORR) but deactivates the H2O2 decomposition capability of the same Co center, as a total result enabling CoPc-S-COF to display outstanding electrocatalytic H2O2 production performance with a remarkable H2O2 selectivity of 95% and a stable H2O2 production with a concentration of 0.48 wt% under a high current density of 125 mA cm-2 at an overpotential of ca. 190 mV for 20 h in a flow cell, representing the thus far reported best H2O2 synthesis COFs electrocatalysts.
Evaluation of Adenosine Deaminase as a Diagnostic Marker in
Tuberculous Pleural Effusion
Authors: Abdelaziz Ali O. , Hassan Rofaida N. , Elghany Elham A. Abd , Abdelfattah Rasha A. , Abdelaziz Nada A. , Hasan Ali A. 
Published: July 2023

Abstract:
Tuberculous pleural effusion (TPE) is a common medical condition more frequently encountered
in poor countries. It is the second most common form of extra-pulmonary tuberculosis.
The diagnosis of TPE is problematic because the clinical features are non-specific, and most laboratory
tests are not diagnostic. An accurate diagnosis requires the detection of TB bacilli in the pleural
fluid or tissue sample from the pleura, which is not an easy task due to the scarcity of bacilli in the
pleural fluid and the need for invasive maneuvers to get pleural tissue for histopathological, bacteriological
or molecular confirmation for the TB bacilli.

:
Different markers in pleural fluid have been evaluated to aid in diagnosing TPE. Among those biomarkers,
Adenosine deaminase (ADA) was the most studied marker. It is an enzyme predominantly
produced by T-lymphocytes and catalyzes the conversion of adenosine to inosine and deoxyadenosine.
It is a hallmark of active cellular immunity. A high level of ADA can be found in exudative
effusion of different etiologies such as parapneumonic, tuberculous and malignant effusions.

:
Although there is still a debate over the diagnostic accuracy of ADA as a marker for TPE, many
studies recommend its use. A correct diagnosis is crucial for the start of treatment for TPE. Therefore,
it is crucial to assess the diagnostic value of adenosine deaminase in diagnosing tuberculous
pleural effusion. The ADA optimal cutoff value is still under investigation.
Mini Review on Polymer-based Nano Enable System for Targeted Delivery
of Chalcone Derivatives against Cancerous Tissues: An Effective Treatment
Approach
Authors: Mukherjee Swarupananda , Karati Dipanjan 
Published: July 2023

Abstract:
Nanotechnology augmentation have enabled the creation of innovative colloidal preparations
that can modify the pharmacological characteristics of medications. Numerous effective applications
in the treatment of cancer have been made possible by the distinctive physicochemical and
technological characteristics of therapies based on nanomaterials. To facilitate and maximize the
interaction between cells and tissues, it is necessary to examine and modify the size, shape, charge,
and patterning of nanoscale therapeutic molecules. The flavonoids chalcones and their natural scaffolds
provide a variety of biological effects crucial for creating medicines. Plant-based anticancer
medicines represent a promising scientific and business opportunity that should be investigated. By
using traditional Chinese medicine (TCM) therapies, diseases can be avoided, and healthcare can be
enhanced. Traditional Chinese medicine is safe, straightforward, and reasonably priced. There are
numerous treatments for chronic, geriatric, and incurable diseases. Heterocyclic equivalents of chalcones
have a variety of biological properties. One of them is its anti-cancer properties, and as a result
Chalcones have drawn a huge interest in the study of malignancy. Licorice is an essential primary
ingredient in many traditional folk medicines, including Chinese and Mongolian medicine. Research
on chalcone scaffolds with strong growth-inhibitory activity in tumor cell lines was influenced
by the rising interest in this medicinal molecule, and numerous papers on these scaffolds are
now accessible. It is necessary to do a thorough examination before chalcone congeners can be developed
as a prodrug or primary chemical to treat cancer. To create a focused and efficient drug delivery
system for cancer treatment, we shall discuss chalcone derivatives and their nano-enabled
drug delivery systems in this article. It has been discussed how polymeric nanoparticles might effectively
localize in particular tumor tissues and act as drug delivery vehicles for anticancer drugs due
to their physicochemical characteristics. A promising strategy to increase the effectiveness of various
tumor treatments is the nanoencapsulation of anticancer active substances in polymeric systems.
Hydroponic Fodders for Livestock Production – a Review
Authors: Pastorelli Grazia , Serra Valentina , Turin Lauretta , Attard Everaldo 
Published: July 2023

Abstract
The human population is expected to reach 9.7 billion by 2050. One of the main challenges will be the demand for food and food security. With time farmland is being lost especially due to environmental change and anthropogenic activities. There is huge competition for the utilization of farmland for human food production, animal feed production, energy production and other sectors that are utilizing the farmland. To minimize the competition between human food and animal feed production, in terms of land use, alternative growing systems, such as hydroponics, may serve to address this problem. Hydroponics is a technology of sprouting grains or growing plants in a soilless environment, with only water or nutrient-rich solution. The present review aims to provide an evaluation of hydroponicallysprouted maize and barley in food producing animals, underlining benefits and limitations in its application.