bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMIKIRAN HUKUM KELUARGA ISLAM KONTEMPORER MUHAMMAD HASBI ASH-SHIDDIEQY DAN KH. M. SAHAL MAHFUD
Authors: Faozan Ahmad 
Published: August 2023

Abstrak
Setiap aktivitas seorang muslim dalam kehidupannya harus sesuai dengan petunjuk syariat. Kehidupan masyarakat yang selalu berubah dari waktu ke waktu, apalagi kini hidup di era kemajuan informasi dan tekhnologi. Hukum Islam yang dihadapkan dengan kondisi dan situasi kekinian harus mampu menjawabnya. Jika ditemukan dalam aktivitas seorang muslim tidak ada dalilnya didalam Al Qur’an dan Al Hadis seorang ulama kontemporer harus secara kreatif dan responsif mencarikan jawabannya. Fatwa sebagai elemen penting dalam hukum Islam menjadi media penghubung untuk menjawab beragam persoalan umat Islam. Sayangnya, banyak jawaban persoalan umat yang dihasilkan masih mengandung problematis dan kurang solutif. Dalam penelitian ini, peneliti menawarkan pemikiran ulama moderat dari Indonesia, Muhammad Hasbi Ash Shidiqy dan KH. M. Sahal Mahfud. Kedua tokoh yang diakui intregritas keilmuannya ini berusaha mengeluarkan kontribusi pemikirannya dalam bidang pemikiran hukum keluarga Islam Indonesia. Mereka menawarkan metodologi yang baru untuk membaca dan memahami teks-teks suci. Serta mendobrak tradisi pemikiran yang mapan yang sudah ada sejak ratusan tahun lalu. Muhammad Hasbi Ash Shidiqy dengan Fiqh Indonesia. Ide dan gagasannya ini merupakan bentuk dari satu keyakinan akan prinsip-prinsip hukum Islam dalam memberikan ruang gerak yang lebar bagi pengembangan atau pembaharuassn ijtihad baru. landasan hukum Islam yang lama dan mapan, seperti ijma’, maslahah mursalah, qiyas, ‘urf, dan prinsip. Terjadinya perubahan hukum karena adanya perubahan masa dan tempat”, justru akan menemui ketidaksesuaian ketika tidak adanya pembaharuan ijtihad baru. Maka haruslah berpegang pada paradigma itu, dalam konteks pembangunan semesta sekarang ini, gerakan penutupan pintu ijtihad (insidad bab al-ijtihad) merupakan isu usang yang harus segera ditinggalkan. Sedangkan KH. M. Sahal Mahfud dengan Fikih Sosialnya mengenalkan sebuah metodologi yang proporsional untuk mencapai kontekstual dan pemahaman yang memenuhi kebutuhan realitas sosial. dengan merumuskan kerangka teoritik berfikih yang lebih produktif dan sesuai dengan perkembangan zaman penting dilakukan.
Kata kunci : Ulama; Fatwa, Ulama, Moderat; Hukum Keluarga Islam Indonesia
Polyyne-producing Burkholderia suppress Globisporangium ultimum damping-off disease of Pisum sativum (pea)
Authors: Webster Gordon , Mullins Alex J. , Petrova Yoana D. , Mahenthiralingam Eshwar 
Published: August 2023

Extensive crop losses are caused by oomycete and fungal damping-off diseases. Agriculture relies heavily on chemical pesticides to control disease, but due to safety concerns multiple agents have been withdrawn. Burkholderia were successfully used as commercial biopesticides because of their fungicidal activity and plant protective traits. However, their potential for opportunistic pathogenicity led to a moratorium on their registration as biopesticides. Subsequently, Burkholderia were shown to produce multiple specialised metabolites including potent antimicrobial polyynes. Cepacin A, a polyyne produced by Burkholderia ambifaria biopesticide strains was shown to be an important metabolite for the protection of germinating peas against Globisporangium ultimum (formerly Pythium) damping-off disease. Recently, there has been an expansion in bacterial polyyne discovery, with the metabolites and their biosynthetic gene pathways found in several bacterial genera including Burkholderia, Collimonas, Trinickia, and Pseudomonas. To define the efficacy of these bacterial polyyne producers as biopesticidal agents, we systematically evaluated metabolite production, in vitro microbial antagonism, and G. ultimum biocontrol across a panel of 30 strains representing four bacterial genera. In vitro polyyne production and antimicrobial activity was demonstrated for most strains, but only Burkholderia polyyne producers were protective within the in vivo G. ultimum damping-off pea protection model. B. ambifaria was the most effective cepacin-expressing biopesticide, and despite their known potential for plant pathogenicity Burkholderia gladioli and Burkholderia plantarii were uniquely shown to be protective as caryoynencin-producing biopesticides. In summary, Burkholderia are effective biopesticides due to their suite of antimicrobials, but the ability to deploy polyyne metabolites, caryoynencin and cepacin, is strain and species dependent.Graphical Abstract
Long-term resting EEG correlates of repetitive mild traumatic brain injury and loss of consciousness: alterations in alpha-beta power
Authors: Franke Laura M. , Perera Robert A. , Sponheim Scott R. 
Published: August 2023

ObjectiveLong-term changes to EEG spectra after mild traumatic brain injury (mTBI, i.e., concussion) have been reported; however, the role of injury characteristics in long-term EEG changes is unclear. It is also unclear how any chronic EEG changes may underlie either subjective or objective cognitive difficulties, which might help explain the variability in recovery after mTBI.MethodsThis study included resting-state high-density electroencephalography (EEG) and mTBI injury data from 340 service members and veterans collected on average 11 years after injury as well as measures of objective and subjective cognitive functioning. The average absolute power within standard bands was computed across 11 spatial regions of the scalp. To determine how variation in brain function was accounted for by injury characteristics and aspects of cognition, we used regression analyses to investigate how EEG power was predicted by mTBI history characteristics [number, number with post-traumatic amnesia and witnessed loss of consciousness (PTA + LOC), context of injury (combat or non-combat), potentially concussive blast exposures], subjective complaints (TBIQOL General Cognitive and Executive Function Concerns), and cognitive performance (NIH Toolbox Fluid Intelligence and premorbid IQ).ResultsPost-traumatic amnesia (PTA) and loss of consciousness (LOC), poorer cognitive performance, and combat experience were associated with reduced power in beta frequencies. Executive function complaints, lower premorbid IQ, poorer cognitive performance, and higher psychological distress symptoms were associated with greater power of delta frequencies. Multiple regression confirmed the relationship between PTA + LOC, poor cognitive performance, cognitive complaints, and reduced power in beta frequencies and revealed that repetitive mTBI was associated with a higher power in alpha and beta frequencies. By contrast, neither dichotomous classification of the presence and absence of mTBI history nor blast exposures showed a relationship with EEG power variables.ConclusionLong-term alterations in resting EEG spectra measures of brain function do not appear to reflect any lasting effect of a history of mTBI or blast exposures. However, power in higher frequencies reflects both injury characteristics and subjective and objective cognitive difficulties, while power in lower frequencies is related to cognitive functions and psychological distress associated with poor long-term outcomes after mTBI.
Evaluation of deep learning models for quality control of MR spectra
Authors: Vaziri Sana , Liu Huawei , Xie Emily , Ratiney Hélène , Sdika Michaël , Lupo Janine M. , Xu Duan , Li Yan 
Published: August 2023

PurposeWhile 3D MR spectroscopic imaging (MRSI) provides valuable spatial metabolic information, one of the hurdles for clinical translation is its interpretation, with voxel-wise quality control (QC) as an essential and the most time-consuming step. This work evaluates the accuracy of machine learning (ML) models for automated QC filtering of individual spectra from 3D healthy control and patient datasets.MethodsA total of 53 3D MRSI datasets from prior studies (30 neurological diseases, 13 brain tumors, and 10 healthy controls) were included in the study. Three ML models were evaluated: a random forest classifier (RF), a convolutional neural network (CNN), and an inception CNN (ICNN) along with two hybrid models: CNN + RF, ICNN + RF. QC labels used for training were determined manually through consensus of two MRSI experts. Normalized and cropped real-valued spectra was used as input. A cross-validation approach was used to separate datasets into training/validation/testing sets of aggregated voxels.ResultsAll models achieved a minimum AUC of 0.964 and accuracy of 0.910. In datasets from neurological disease and controls, the CNN model produced the highest AUC (0.982), while the RF model achieved the highest AUC in patients with brain tumors (0.976). Within tumor lesions, which typically exhibit abnormal metabolism, the CNN AUC was 0.973 while that of the RF was 0.969. Data quality inference times were on the order of seconds for an entire 3D dataset, offering drastic time reduction compared to manual labeling.ConclusionML methods accurately and rapidly performed automated QC. Results in tumors highlights the applicability to a variety of metabolic conditions.
Barriers associated with pulse and plant-based meat alternative consumption across sociodemographic groups: a Capability, Opportunity, Motivation, Behaviour model approach
Authors: Kuosmanen Sini , Niva Mari , Pajari Anne-Maria , Korhonen Kirsi , Muilu Toivo , Konttinen Hanna 
Published: August 2023

IntroductionTo enhance environmental sustainability and food security, there should be a change in dietary protein consumption. It is suggested that meat consumption should be reduced and that the currently low consumption of pulses and other plant-based proteins should increase. We aimed to examine (1) how sociodemographic factors and perceived barriers are associated with self-reported current and perceived future pulse and other plant-based meat alternative (PBMA) consumption and (2) how sociodemographic factors relate to perceived barriers.MethodsParticipants were 18–75 year-old Finnish adults (n = 1,000). Multivariable logistic regression was used as the main analysis technique. The results were interpreted by employing the Capability, Opportunity, Motivation, Behaviour (COM-B) model.ResultsPulses were consumed more often than PBMAs and lower education level and financial strain were associated with more infrequent pulse and PBMA use. The most common perceived barriers for pulse consumption were unfamiliarity, expensive price, and unpleasant taste, which can be interpreted to represent the capability, opportunity and motivation components of the COM-B model, respectively. Women, the young, and financially strained perceived more barriers limiting their pulse consumption than others.DiscussionTo increase plant-based food consumption, it is important that tasty, easy to use and affordable plant-based foods are available for all. Additionally, we suggest that food services should be encouraged to increase the use of pulses in their dishes and that capabilities, opportunities and motivations are taken into account in intervention measures advancing plant protein consumption.
Impact of feeding volumes in the first 24 h of life on neonatal feeding intolerance
Authors: Kumar Navin , Oredein Igbagbosanmi , Al-Nahar Mohammed , Harris Nathalee , Sampath Venkatesh 
Published: August 2023

ObjectiveThis study investigates whether volumes of intake in the first 24 h of life (24 HOL), in relation to birth weight (BW) and gestational age (GA), impact neonatal feeding intolerance (FI).MethodsThis study employed a retrospective chart review of 6,650 infants born at ≥35 weeks. The volumes of each formula feed per kg BW in the first 24 HOL were assessed. FI was defined as evidenced by chart documentation of emesis, abdominal distension, abdominal x-ray, and/or switching to a sensitive formula.ResultsOverall, the maximum volume of formula intake per feed was inversely correlated with GA and was higher in infants with FI (β = −1.39, p &lt; 0.001) compared with infants without FI (β = −1.28, p &lt; 0.001). The odds of emesis in late preterm infants with first feeding of &gt;8 ml/kg [adjusted odds ratio (AOR) = 2.5, 95% confidence interval (CI): 1.4–4.6] and formula switching in the exclusively formula-fed group with volumes &gt;10.5 ml/kg [AOR =  2.2, 95% CI (1.8–2.6)] were high. In the breastfeeding group, the odds of FI increased by 2.8-, 4.6-, and 5.2-fold with 5–10, 10–15, and &gt;15 ml/kg of supplementations, respectively.ConclusionA higher volume of intake in relation to BW often exceeds the physiological stomach capacity of newborns and is associated with early FI. Optimizing early feeding volumes based on infant BW and GA may decrease FI, which may be an issue of volume intolerance.
Dasatinib suppresses particulate-induced pyroptosis and acute lung inflammation
Authors: Pan Yixi , Ikoma Kenta , Matsui Risa , Nakayama Akiyoshi , Takemura Naoki , Saitoh Tatsuya 
Published: August 2023

Background: Humans are constantly exposed to various industrial, environmental, and endogenous particulates that result in inflammatory diseases. After being engulfed by immune cells, viz. Macrophages, such particulates lead to phagolysosomal dysfunction, eventually inducing pyroptosis, a form of cell death accompanied by the release of inflammatory mediators, including members of the interleukin (IL)-1 family. Phagolysosomal dysfunction results in the activation of the nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, an immune complex that induces pyroptosis upon exposure to various external stimuli. However, several particulates induce pyroptosis even if the NLRP3 inflammasome is inhibited; this indicates that such inhibition is not always effective in treating diseases induced by particulates. Therefore, discovery of drugs suppressing particulate-induced NLRP3-independent pyroptosis is warranted.Methods: We screened compounds that inhibit silica particle (SP)-induced cell death and release of IL-1α using RAW264.7 cells, which are incapable of NLRP3 inflammasome formation. The candidates were tested for their ability to suppress particulate-induced pyroptosis and phagolysosomal dysfunction using mouse primary macrophages and alleviate SP-induced NLRP3-independent lung inflammation.Results: Several Src family kinase inhibitors, including dasatinib, effectively suppressed SP-induced cell death and IL-1α release. Furthermore, dasatinib suppressed pyroptosis induced by other particulates but did not suppress that induced by non-particulates, such as adenosine triphosphate. Dasatinib reduced SP-induced phagolysosomal dysfunction without affecting phagocytosis of SPs. Moreover, dasatinib treatment strongly suppressed the increase in IL-1α levels and neutrophil counts in the lungs after intratracheal SP administration.Conclusion: Dasatinib suppresses particulate-induced pyroptosis and can be used to treat relevant inflammatory diseases.
Successful treatment of lung adenocarcinoma complicated with a rare compound EGFR mutation L833V/H835L using aumolertinib: a case report and literature review
Authors: Li Linlin , Huang Siyuan , Qin Liying , Yan Ningning , Shen Shujing , Li Xingya 
Published: August 2023

Background: The deletion of exon 19 and the Leu858Arg mutation of exon 21 are the most frequently observed mutations in the epidermal growth factor receptor (EGFR) gene, and patients with these mutations have shown significant benefits from EGFR-tyrosine kinase inhibitors (TKIs). However, there exists a small subgroup of patients with uncommon/rare mutations of EGFR, including compound mutations, which display a high degree of heterogeneity in terms of clinical features and variable sensitivities to EGFR-TKIs. The understanding of these uncommon mutations and their response to targeted therapy is still unclear and requires further investigation.Case presentation: We presented a case of a never-smoking patient with lung adenocarcinoma and brain metastasis. Initially, she received chemotherapy plus immune checkpoint inhibitor as first-line therapy as no EGFR mutations were detected by amplification-refractory mutation system-polymerase chain reaction. However, disease progressed rapidly. Subsequently, next-generation sequencing was carried out and revealed a rare compound mutation, L833V/H835L, in exon 21 of EGFR. As a result, she was switched to second-line therapy with the third-generation TKI aumolertinib, which demonstrated good efficacy. The patient was evaluated for a remarkable progression-free survival of 18 months and an overall survival of 29 months.Conclusion: The present study supports that aumolertinib might be a good treatment option for advanced NSCLC patients with EGFR L833V/H835L mutation, particularly in patients with brain metastasis. Furthermore, conducting a comprehensive screening for gene mutations is crucial in effectively identifying potential oncogenic driver mutations and guiding mutation-targeted therapy decisions in clinical practice.
The impact of the intensity of media use on potential tourists’ risk perception and travel protective behavioral intentions in COVID-19
Authors: Sun Ruihong , Ye Xinliang , Tang Jianping , Yang Jiexi , Scott Noel 
Published: August 2023

IntroductionIn light of the COVID-19 pandemic, there is an increased need for potential travelers to gather information about their trips to mitigate perceived risks. This study aims to understand the relationship between the intensity of media use (both new and traditional), epidemic risk perception, and tourism protection behavior intention among potential tourists.MethodsA total of 491 valid questionnaires were collected in Shanghai, China. Factor analysis, path analysis, and effect analysis were conducted using SPSS and AMOS to examine the impact of different media types on epidemic risk perception and tourism protection behavior.ResultsThe findings indicate a positive association between new media use intensity and epidemic risk perception, as well as an intention to adopt safety-conscious tourism behaviors. In contrast, traditional media usage is inversely associated with risk perception but has no significant influence on protective behavior. The results also highlight the role of demographic factors, such as age, education level, occupation, and income, in modulating the relationship between media usage and risk perception.DiscussionThe contrasting effects of new and traditional media suggest the need for a tailored approach in epidemic communication strategies. Public health officials should leverage new media to enhance risk perception and safety-oriented behaviors, while recognizing the role of traditional media in managing lower risk perceptions and assuaging panic. The study emphasizes the importance of personalized messaging based on demographic disparities in media usage and perception. The mediating role of risk perception in shaping protective behaviors offers insights for promoting adherence to safety protocols.ConclusionThis study contributes to a comprehensive understanding of media influences during health crises, emphasizing the responsibility of media platforms in transmitting accurate information. The findings call for a nuanced approach to epidemic communication, considering the strengths and weaknesses of different media types. Segmented and personalized messaging strategies can cater to demographic variations in media usage and perception. Enhancing risk perception through tailored messaging can promote protective behaviors and effectively manage public sentiment during health crises.
Trends in bio-behavioural risk factors of non-communicable diseases among adults in Sao Tome and Principe
Authors: Pengpid Supa , Peltzer Karl 
Published: August 2023

BackgroundUnderstanding national trends in risk factors of noncommunicable diseases (NCDs) may have health policy implications. The aim of the study was to assess the prevalence and social and demographic factors associated with risk factors of NCDs in adults from 2008 to 2019 in Sao Tome and Principe.MethodsIn repeat cross-sectional national STEPS surveys 2,457 adults (median age 37 years) in 2008 and 1,893 adults (median age 38 years) in 2019 in Sao Tome and Principe responded to structured interviews, physical and biochemical measures. Logistic regressions were applied to estimate predictors of NCD risk factors.ResultsHaving three to seven NCD risk factors significantly decreased among men but not women from 36.6% in 2008 to 26.8% in 2019. The proportion of specific risk factors of NCD increased significantly for low physical activity from 17.4% in 2008 to 30.9% in 2019, and overweight/obesity from 37.3% in 2008 to 51.0% in 2019. Insufficient fruit/vegetable consumption decreased from 83.1% in 2008 to 53.3% in 2019, frequent alcohol use from 32.6% in 2008 to 24.8% in 2019, and diabetes from 3.1% in 2008 to 1.2% in 2019, while the proportion of current tobacco use and hypertension remained unchanged from 2008 to 2019. Men engaged more often than women in current tobacco use and frequent alcohol use, and women had higher rates of low physical activity and overweight/obesity than men. Higher educational levels were positively associated with overweight/obesity, and inversely associated with frequent alcohol use and inadequate fruit/vegetable intake.ConclusionBetween 2008 and 2019, the prevalence of seven risk factors for NCDs in Sao Tome and Principe declined among men, but not among women. Several associated variables have been identified for each individual risk factor of NCD that may help guide interventions.
Paucity of Health Data in Africa: An Obstacle to Digital Health Implementation and Evidence-Based Practice
Authors: Musa Sulaiman Muhammad , Haruna Usman Abubakar , Manirambona Emery , Eshun Gilbert , Ahmad Dalhatu Muhammad , Dada David Adelekan , Gololo Ahmed Adamu , Musa Shuaibu Saidu , Abdulkadir Abdulafeez Katibi , Lucero-Prisno III Don Eliseo 
Published: August 2023

Background: Among the numerous challenges that Africa faces in improving its healthcare systems, the paucity of health data stands out as paramount. This study aims to examine the challenges related to the paucity of health data in Africa and its impact on the implementation of digital health and evidence-based practice. The findings of the study reveal that health data availability in Africa is both limited and frequently of poor quality. Several factors contribute to this concerning situation, encompassing inadequate infrastructure, a shortage of resources, and cultural barriers. Furthermore, the available data, despite its limitations, is often underutilized due to a lack of capacity and expertise in data analysis and interpretation.Policy Options and Recommendations: To improve healthcare delivery in Africa, we recommend implementing novel strategies for data collection. It’s important to recognize that effective information technology service is crucial for enhancing healthcare delivery, and a holistic approach is necessary to achieve this.Conclusion: This brief presents information to help policymakers develop long-term solutions to Africa’s health data poverty. Taking action based on this evidence can assist in addressing the problem.