bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why supply chain complexity prevails: mapping the complexity capability development process
Authors: Gerschberger Markus , Fawcet Stanley E. , Fawcett Amydee M. , Gerschberger Melanie 
Published: April 2023

PurposeComplexity has been called the 21st-century supply chain (SC) challenge. Most SC managers view it as a necessary evil, ever-present, costly and tough to manage, and few prioritize it. Still, anecdotes suggest some leverage it to drive operational excellence. This study aims to explore how they do it, delving into the development of a complexity management capability, under what circumstances it emerges and its effect on competitiveness.Design/methodology/approachTo better understand why, and how, companies develop (or not) a distinctive SC complexity management capability, this study employed an inductive study of 10 leading European companies, each operating a complex SC.FindingsAlthough SC complexity raises costs, increases disruptions and makes decision-making difficult, few companies have made complexity management a priority. Among those, most focus on reducing or absorbing complexity to improve operational excellence. A few invest to develop a distinctive SC complexity management capability. They manage complexity for market success. The interaction among competitive pressures, managerial attitudes and investments delineate a dynamic capability development process.Research limitations/implicationsDespite extensive research on complexity drivers, the tools used to manage SC complexity and the impact of SC complexity on performance, the interplay among factors that promote, or hinder, the development of an SC complexity capability continues to be poorly understood. By mapping the complexity capability development process, this study explicates a more nuanced approach to managing SC complexity that can yield a competitive edge.Practical implicationsSC complexity prevails because the dynamic, iterative complexity capability development process is overlooked. Managers can use the complexity capability roadmap to assess the cost/benefits of pursuing a distinctive complexity management capability more accurately.Originality/valueThis study demystifies the development of a complexity management capability, showing how some companies develop the capability to distinguish between value-added and value-dissipating complexity and thus become empowered to leverage SC complexity for competitive advantage.
TRIZ inventive principle in healthcare quality and innovation development
Authors: Tonjang Suebsakul , Thawesaengskulthai Natcha 
Published: April 2023

PurposeThis research aimed to create inventive principles in managing quality and innovation systems that can be used as a guide for the development of effective innovation projects in hospitals.Design/methodology/approachTotal quality and innovation management in healthcare (TQIM-H) framework and theory of inventive problem-solving (TRIZ) were integrated with results from in-depth interviews with 30 healthcare experts, resulting in TQIM-H inventive principle. The developed inventive principle was validated using 50 effective innovation projects from one of the largest healthcare conglomerates in Southeast Asia.FindingsThe TQIM-H inventive principle consisted of 7 dimensions and 72 procedures for creating innovation in hospitals under the medical quality framework. The principle effectively helps innovators develop innovative solutions that still strictly comply with medical guidelines.Originality/valueInnovation is recognized as a critical factor that helps organizations adapt to global changes and increases the potential for competition, especially in hospitals. However, creating innovation in hospitals has a lower success rate than in other industries because, in general, ineffective innovation development strategies are used and the created innovation is not aligned with regulations and restrictions regarding healthcare quality in the healthcare system.
Those were the what? Contents of nostalgia, relative deprivation and radical right support
Authors: VERSTEEGEN PETER LUCA 
Published: April 2023

AbstractRecent research suggests that emotions are a central motivation for radical right voting. One emotion that has gained particular interest is nostalgia: Radical right politicians use nostalgic rhetoric, and feeling nostalgic is associated with radical right support. However, while nostalgia is widely and frequently experienced, previous work differentiates personal contents of nostalgia (e.g., childhood) from group‐based contents (e.g., traditions) and suggests that only the latter is related to the radical right. But why does nostalgia, and specifically its group‐based content, matter? In the present paper, I argue that nostalgia evokes implicit comparisons between the past and the present. Using relative deprivation theory, I posit that group‐based nostalgia makes people subjectively evaluate society's present as worse than its past. In turn, this temporal group‐based relative deprivation is associated with attempts to restore the past through radical right voting. Personal nostalgia, instead, does not evoke equivalent experiences of personal relative deprivation and is, therefore, unrelated to radical right support. In preregistered analyses of representative panel data from the Netherlands, I show that group‐based nostalgia is more consistently related to radical right support than personal nostalgia. In subsequent exploratory analyses, I test the relative deprivation argument and find that group‐based relative deprivation does indeed mediate the relationship between group‐based nostalgia and radical right voting: People who long for the group‐based past are more likely to feel dissatisfied with the government and, in turn, consider voting for the radical right. In studying this mechanism, I connect recent work on emotional and relative deprivation explanations to radical right voting.
PSMA‐PET‐guided dose‐escalated volumetric arc therapy for newly diagnosed lymph node‐positive prostate cancer: 5 Year outcomes following the FROGG and EviQ node‐positive guidelines
Authors: Yap Shaun Zheng Liang , Armstrong Shreya , Aherne Noel , Shakespeare Thomas Philip 
Published: April 2023

AbstractIntroductionThe Royal Australian and New Zealand College of Radiologists (RANZCR) Faculty of Radiation Oncology Genitourinary Group (FROGG) guidelines and online EviQ protocols incorporate prostate‐specific membrane antigen (PSMA) positron emission tomography (PET)‐guided dose‐escalated intensity‐modulated radiation therapy (DE‐IMRT) for newly diagnosed lymph node (LN) positive prostate cancer. We evaluated late toxicity and efficacy outcomes following the FROGG and EviQ approach.MethodsPatients with LN‐positive‐only metastases on PSMA‐PET imaging were offered curative therapy with 3 months neoadjuvant androgen deprivation therapy (ADT) followed by DE‐IMRT and 3 years adjuvant ADT. IMRT was delivered via volumetric arc therapy (VMAT). We aimed to deliver 81 Gy in 45 fractions (Fx) to the prostate and PET‐positive LNs, and 60 Gy in 45 Fx to elective pelvic nodes, contoured using the PIVOTAL guidelines.ResultsForty‐five patients were included. The median number of PET‐positive nodes boosted was 2 (range 1–6) and median boost volume 1.16 cc (range 0.15–4.14). Seventeen (38%) patients had PET‐positive nodes outside of PIVOTAL contouring guidelines. With 60 months median follow‐up, disease‐free, metastasis‐free, prostate cancer‐specific and overall survival were 88.1%, 95.3%, 100% and 91.5%. There were no in‐field nodal failures. Late grade 1, 2 and 3 gastrointestinal toxicities occurred in 4%, 2% and 0% of patients, and genitourinary toxicity in 18%, 18% and 4%. Lower limb grade 2 lymphoedema occurred in three patients (7%).ConclusionOutcomes following FROGG guidelines and EviQ are promising, with high long‐term disease control and low toxicity. Contouring guidelines require modification due to the high rate of PET‐positive nodes demonstrated beyond recommended coverage.
A second unveiling: Haplotig masking of the eastern oyster genome improves population‐level inference
Authors: Puritz Jonathan B. , Guo Ximing , Hare Matthew , He Yan , Hillier LaDeana W. , Jin Shubo , Liu Ming , Lotterhos Katie E. , Minx Pat , Modak Tejashree , Proestou Dina , Rice Edward S. , Tomlinson Chad , Warren Wesley C. , Witkop Erin , Zhao Honggang , Gomez‐Chiarri Marta 
Published: April 2023

AbstractGenome assembly can be challenging for species that are characterized by high amounts of polymorphism, heterozygosity, and large effective population sizes. High levels of heterozygosity can result in genome mis‐assemblies and a larger than expected genome size due to the haplotig versions of a single locus being assembled as separate loci. Here, we describe the first chromosome‐level genome for the eastern oyster, Crassostrea virginica. Publicly released and annotated in 2017, the assembly has a scaffold N50 of 54 mb and is over 97.3% complete based on BUSCO analysis. The genome assembly for the eastern oyster is a critical resource for foundational research into molluscan adaptation to a changing environment and for selective breeding for the aquaculture industry. Subsequent resequencing data suggested the presence of haplotigs in the original assembly, and we developed a post hoc method to break up chimeric contigs and mask haplotigs in published heterozygous genomes and evaluated improvements to the accuracy of downstream analysis. Masking haplotigs had a large impact on SNP discovery and estimates of nucleotide diversity and had more subtle and nuanced effects on estimates of heterozygosity, population structure analysis, and outlier detection. We show that haplotig masking can be a powerful tool for improving genomic inference, and we present an open, reproducible resource for the masking of haplotigs in any published genome.
Epley maneuver for benign paroxysmal positional vertigo: Evidence synthesis for guidelines for reasonable and appropriate care in the emergency department
Authors: Khoujah Danya , Naples James G. , Oliveira J. e Silva Lucas , Edlow Jonathan A. , Gerberi Danielle J. , Carpenter Christopher R. , Bellolio Fernanda 
Published: April 2023

AbstractBackgroundCanalith repositioning maneuvers (such as the Epley maneuver) are recommended by specialty guidelines for management of benign paroxysmal positional vertigo (BPPV) yet are frequently underutilized in the emergency department (ED).MethodsWe conducted a systematic review (SR) of SRs to summarize the evidence of Epley maneuver for the treatment of posterior canal (pc) BPPV in any setting. We included SRs of randomized controlled trials (RCTs) that compared Epley to control in adult patients with pc‐BPPV. Titles, abstracts, and full texts were screened in duplicate. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) assessment was used to rate certainty of evidence. Odds ratios (ORs) and 95% confidence intervals (CIs) are reported. Meta‐analysis of individual studies was conducted with random and fixed effects.ResultsFrom 2228 titles, seven SRs were selected for quality assessment. One review was of higher methodological quality, included only RCTs, and was the most current and comprehensive. Five of the 11 RCTs of the review, including 312 patients with pc‐BPPV diagnosed by Dix–Hallpike, were relevant to our question. Meta‐analysis of four RCTs (251 patients) showed the use of Epley (compared to control) was associated with higher complete resolution of vertigo at 1 week (OR 7.19, 95% CI 1.52–33.98, moderate certainty). Meta‐analysis of three RCTs (195 patients) showed the use of Epley was associated with higher conversion to negative Dix–Hallpike at 1 week (OR 6.67, 95% CI 1.52–33.98, moderate certainty). The number‐needed‐to‐treat was three. Meta‐analysis of the outcomes at 1 month, and when observational studies were included, showed similar results. No serious adverse effects were reported.ConclusionsSymptoms of pc‐BPPV improve with the Epley maneuver. Emergency clinicians should become familiar with performing the Epley for BPPV. Further studies on ED implementation and clinician education of Epley are needed.
Gender diversity in urology scientific meetings: an analysis of the last nine years
Authors: Graham Vaite , Bray Gerard , Lyon Kate 
Published: April 2023

AbstractBackgroundThe importance of gender diversity is well recognized. Despite promising change in addressing gender disparity, there remains a significant gap in women's representation in urology. Worldwide, a lack of diversity has been observed at scientific meetings. This study analyses the trend in women's representation at the Urological Society of Australia and New Zealand Annual Scientific Meeting (USANZ ASM) over the last nine years.MethodWe retrospectively collected data from eight conference programs between 2014 and 2022, evaluating the trend in the proportion of women represented in various sections. A difference of proportions test was performed to determine whether a significant change was seen from year to year.ResultsA significant increase in women's representation was observed, the most significant increase was evident in the last three years, chairpersons increased from 5.9% to 44.1% (P = 0.003), international speakers from 11.7% to 39.1% (P ≤ 0.001), expert speakers from 19.1% to 42.0% (P = 0.002), and total speakers from 19.5% to 34.7% (P ≤ 0.001).ConclusionOur study shows that a significant increase in the representation of women at the USANZ ASM has been achieved over the last three years. Unfortunately, this increase in representation has not been mirrored in the number of women trainees and training applicants. Additionally, this increase in representation well exceeds the proportion of women who are USANZ members, and is unevenly distributed across topics. A positive change has been observed, the challenge remains in dealing with unconscious bias and balancing the fine line between inclusivity and tokenism.
Dual dialyzer hemodiafiltration: A new extracorporeal dialysis treatment modality for patients with end‐stage kidney disease
Authors: Glancey Gerald 
Published: April 2023

AbstractBackgroundThe introduction of high flux (HF) hemodialyzers and their application in single dialyzer hemodiafiltration (sdHDF) for patients on extracorporeal dialysis (ECD) therapy has improved the extraction of uremic toxins, including the low molecular weight protein (LMWP) beta 2 microglobulin (β2M, 11.6 kDa). Similar increases in the extraction of protein‐bound uremic toxins (PBUT) and larger LMWP (15‐50 kDa) remain elusive. High concomitant losses of albumin prohibit the use of medium cutoff (MCO) or protein‐losing hemodialyzers for sdHDF to increase the extraction of these molecules by convective transfer.MethodsA new extracorporeal dialysis treatment modality, dual dialyzer hemodiafiltration (ddHDF), has been designed together with a mathematical model to compare its predicted performance to that of sdHDF in the extraction of solute. The extra process that distinguishes ddHDF from sdHDF is the secondary ultrafiltration and partial reinfusion of the effluent hemodiafiltrate from the primary hemodialyzer. This allows MCO and protein‐losing hemodialyzers to be used to increase the extraction of both LMWP and PBUT without excessive concomitant loss of albumin.ResultsData from the mathematical model show that ddHDF could increase the extraction of smaller and larger LMWP by an extra 102% and 220%, respectively, compared to standard HF sdHDF, while restricting the loss of albumin to 0.83 g per hour of treatment. In using albumin as a recyclable carrier molecule for the extraction of PBUT from plasma ddHDF has the potential to increase PBUT reduction ratios (RR's) to 49% by convection alone. Even higher RR's are possible if the dialysate volume flow rate can be increased beyond 600 mL/min.ConclusionddHDF provides an opportunity for a step change increase in the level of extraction of both larger LMWP and PBUT in patients with end‐stage kidney disease.
SARM1 promotes the neuroinflammation and demyelination through IGFBP2/NF‐κB pathway in experimental autoimmune encephalomyelitis mice
Authors: Zhang Jingjing , Jin Lingting , Hua Xin , Wang Mianxian , Wang Jiaojiao , Xu Xingxing , Liu Huitao , Qiu Haoyu , Sun Huankun , Dong Tianyingying , Yang Danlu , Zhang Xu , Wang Ying , Huang Zhihui 
Published: April 2023

AbstractAimMultiple sclerosis (MS) is an autoimmune disease, and its typical characteristics are neuroinflammation and the demyelination of neurons in the central nervous system (CNS). Sterile alpha and TIR motif containing 1 (SARM1) is an essential factor mediating axonal degeneration and SARM1 deletion reduces the neuroinflammation in spinal cord injury. This study aimed to explore the roles of SARM1 and its underlying mechanisms in MS.MethodsExperimental autoimmune encephalomyelitis (EAE, a model of MS) model was established. Immunostaining, western blot, electron microscope, and HE staining were used to examine the pathological manifestations such as inflammation, demyelination, and neuronal death in SARM1f/f EAE mice and SARM1Nestin‐CKO EAE mice. In addition, RNA‐seq, real‐time PCR and double‐immunostaining were used to examine the underlying mechanism of SARM1 in EAE mice.ResultsSARM1 was upregulated in neurons of the spinal cords of EAE mice. SARM1 knockout in CNS ameliorated EAE with less neuroinflammation, demyelination, and dead neurons. Mechanically, SARM1 knockout resulted in the reduction of insulin‐like growth factor (IGF)‐binding protein 2 (IGFBP2) in neurons of EAE mice, which might inhibit the neuroinflammation through inhibiting NF‐κB signaling. Finally, activation of NF‐κB partially aggravated the neuroinflammation and demyelination deficits of SARM1Nestin‐CKO EAE mice.ConclusionsThese results identified the unknown role of SARM1 in the promotion of neuroinflammation and demyelination and revealed a novel drug target pathway of SARM1/IGFBP2/NF‐κB for MS.
Notes on the female reproductive system of the red‐and‐black froghopper, Cercopis vulnerata Rossi, 1807 (Hemiptera: Cercopidae)‐light and electron microscopy studies
Authors: Özyurt Koçakoğlu Nurcan , Candan Selami , Arslan Hicret 
Published: April 2023

AbstractThe morphology of the female reproductive system in Cercopis vulnerata, an economically important species, was examined with light and scanning electron microscopy techniques. The female reproductive system of C. vulnerata has two ovaries, each containing 14 telotrophic meroistic ovarioles joined by two lateral oviducts that open in a common oviduct. In this type of ovarioles, the trophocytes within the germarium are transferred to the developing oocytes in the vitellarium via the nutritive cords. The oocytes in the vitellarium have three different development stages: previtello, vitello and choriogenesis. The ovarioles open in the lateral oviduct with a thin canal‐shaped pedicel. A pair of lateral oviducts opens distally into the common oviduct. The oviducts are surrounded by a monolayer cubical epithelium with deep folds toward the lumen and a thick muscle layer. A pair of spermatheca and a bursa copulatrix are seen near the common oviduct. Spermatheca has an elongated shape. The bursa copulatrix has an ovoid tube‐like structure. No work has been done on the female reproductive system of Cercopidae to date. This study was conducted to fill this gap and forms part of the female reproductive system morphology of this economically important insect.
Triptolide alleviates collagen‐induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN‐STAT3 pathway
Authors: Huang Yao , Ba Xin , Wang Hui , Shen Pan , Han Liang , Lin Weiji , Yan Jiahui , Chen Zhe , Tu Shenghao 
Published: April 2023

AbstractBackgroundThis study aimed to investigate the effects of triptolide (TP) on collagen‐induced arthritis (CIA) mice and the related mechanisms.MethodsCIA mice were administered TP for 35 days. Mouse ankle joints and serum antibodies and cytokines were examined to assess the therapeutic effects of TP. The ratios of Treg, Th1 and Th17 cells were measured by flow cytometry and RT‐qPCR. Reverse docking was used to characterize the binding modes of TP against target proteins. The expression of the STAT3 pathway in CIA mice was evaluated by western blotting and immunofluorescence staining. Mouse spleen lymphocytes were extracted, and the expression of the STAT3 pathway after IL‐6 stimulation was analysed.ResultsTP could significantly alleviate joint swelling, reduce bone destruction and downregulate serum inflammation levels. TP improved the imbalance of Treg/Th17 cells in CIA mice. TP could form stable complexes with target proteins. TP significantly inhibited the activation of the JAK/PTEN‐STAT3 pathway in mice. Moreover, TP regulated the activation of the JAK1/2‐STAT3 signalling pathway in mouse spleen lymphocytes under inflammatory stimulation.ConclusionTP can inhibit inflammation and alleviate bone destruction in CIA mice. The underlying mechanism is related to the regulation of the imbalance of Treg/Th17 cells through the JAK/PTEN‐STAT3 pathway.
Factors associated with preemptive conservation under the U.S. Endangered Species Act
Authors: Treakle Tyler , Epanchin‐Niell Rebecca , Iacona Gwenllian D. 
Published: April 2023

AbstractIn recent decades, there has been an increasing emphasis on proactive efforts to conserve species being considered for listing under the U.S. Endangered Species Act (ESA) before they are listed (i.e., preemptive conservation). These efforts, which depend on voluntary actions by public and private land managers across the species’ range, aim to conserve species while avoiding regulatory costs associated with ESA listing. We collected data for a set of social, economic, environmental, and institutional factors that we hypothesized would influence voluntary decisions to promote or inhibit preemptive conservation of species under consideration for ESA listing. We used logistic regression to estimate the association of these factors with preemptive conservation outcomes based on data for a set of species that entered the ESA listing process and were either officially listed (n = 314) or preemptively conserved (n = 73) from 1996 to 2018. Factors significantly associated with precluded listing due to preemptive conservation included high baseline conservation status, low proportion of private land across the species’ range, small total range size, exposure to specific types of threats, and species’ range extending over several states. These results highlight strategies that can help improve conservation outcomes, such as allocating resources for imperiled species earlier in the listing process, addressing specific threats, and expanding incentives and coordination mechanisms for conservation on private lands.
Predictive Sentence Processing at Speed: Evidence from Online Mouse Cursor Tracking
Authors: Kukona Anuenue 
Published: April 2023

AbstractThree online mouse cursor‐tracking experiments investigated predictive sentence processing at speed. Participants viewed visual arrays with objects like a bike and kite while hearing predictive sentences like, “What the man will ride, which is shown on this page, is the bike,” or non‐predictive sentences like, “What the man will spot, which is shown on this page, is the bike.” Based on the selectional restrictions of “ride” (i.e., vs. “spot”), participants made mouse cursor movements to the bike before hearing the noun “bike.” Compellingly, this effect was observed at speech rates of ∼3 (Experiment 1), ∼6 (Experiment 2), and ∼9 (Experiment 3) syllables/s. While prior research suggests striking limits on prediction, these results highlight temporal dynamics that may impact comprehenders’ ability to preactivate information when hearing impressively rapid speech. Implications for theories of sentence processing are discussed.