bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing contrast agent residuals in hospital wastewater: the GREENWATER study protocol
Authors: Zanardo Moreno , Cozzi Andrea , Cardani Rosanna , Renna Laura Valentina , Pomati Francesco , Asmundo Luigi , Di Leo Giovanni , Sardanelli Francesco 
Published: May 2023

AbstractThe potential enviromental impact of iodinated (ICAs) and gadolinium-based contrast agents (GBCAs) have recently come under scrutiny, considering the current nonselective wastewater treatment. However, their rapid excretion after intravenous administration could allow their potential recovery by targeting hospital sewage. The GREENWATER study aims to appraise the effective quantities of ICAs and GBCAs retrievable from patients’ urine collected after computed tomography (CT) and magnetic resonance imaging (MRI) exams, selecting ICA/GBCA per-patient urinary excretion and patients’ acceptance rate as study endpoints. Within a prospective, observational, single-centre, 1-year framework, we will enrol outpatients aged ≥ 18 years, scheduled to perform contrast-enhanced CT or MRI, willing to collect post-examination urine in dedicated canisters by prolonging their hospital stay to 1 h after injection. Collected urine will be processed and partially stored in the institutional biobank. Patient-based analysis will be performed for the first 100 CT and 100 MRI patients, and then, all analyses will be conducted on the pooled urinary sample. Quantification of urinary iodine and gadolinium will be performed with spectroscopy after oxidative digestion. The evaluation of the acceptance rate will assess the “environmental awareness” of patients and will aid to model how procedures to reduce ICA/GBCA enviromental impact could be adapted in different settings.Key points• Enviromental impact of iodinated and gadolinium-based contrast agents represents a growing point of attention.• Current wastewater treatment is unable to retrieve and recycle contrast agents.• Prolonging hospital stay may allow contrast agents retrieval from patients’ urine.• The GREENWATER study will assess the effectively retrievable contrast agents’ quantities.• The enrolment acceptance rate will allow to evaluate patients’ “green sensitivity”.
Stingless bee propolis: composition, biological activities and its applications in the food industry
Authors: Rocha Vítor Moreira , Portela Ricardo Dias , dos Anjos Jeancarlo Pereira , de Souza Carolina Oliveira , Umsza-Guez Marcelo Andrés 
Published: May 2023

AbstractThe breeding of stingless bees, known as meliponiculture, can be found throughout the world, and is closely linked to the history of the first human communities in the Americas. This activity provides products of industrial interest (food, cosmetics, pharmaceuticals), and among them propolis stands out. This matrix is a resinous material but being difficult to classify and conceptualize due to its variability according to the environment and producing species. The propolis produced by these bees is a source of compounds with nutritional and functional potential, but the main interest is focused on the phenolic compounds. This potential makes propolis a product that can be used in the prospection of new molecules with antimicrobial and antioxidant activity. Thus, the scientific literature describes propolis activity (generally extracts) against bacteria and fungi, but with a higher microbicidal activity against gram-positive bacteria. The high antioxidant activity of this bee product is a consequence of the presence of several phenolic compounds. The use of propolis from SBP (Stingless bee propolis) is still quite limited, generally restricted to its antioxidant potential, but studies with application in other sectors can benefit this productive sector, as with the propolis produced by the bee Apis mellifera. This work presents and discusses the composition of stingless bee propolis and its consequent biological activities, as well as its potential applications in the food industry.
Graphical Abstract
Nitrogen uptake and remobilization from pre- and post-anthesis stages contribute towards grain yield and grain protein concentration in wheat grown in limited nitrogen conditions
Authors: Sharma Sandeep , Kumar Tarun , Foulkes M. John , Orford Simon , Singh Anju Mahendru , Wingen Luzie U. , Karnam Venkatesh , Nair Lekshmy S. , Mandal Pranab Kumar , Griffiths Simon , Hawkesford Malcolm J. , Shewry Peter R. , Bentley Alison R. , Pandey Renu 
Published: May 2023

Abstract
Background
In wheat, nitrogen (N) remobilization from vegetative tissues to developing grains largely depends on genetic and environmental factors. The evaluation of genetic potential of crops under limited resource inputs such as limited N supply would provide an opportunity to identify N-efficient lines with improved N utilisation efficiency and yield potential. We assessed the genetic variation in wheat recombinant inbred lines (RILs) for uptake, partitioning, and remobilization of N towards grain, its association with grain protein concentration (GPC) and grain yield.

Methods
We used the nested association mapping (NAM) population (195 lines) derived by crossing Paragon (P) with CIMMYT core germplasm (P × Cim), Baj (P × Baj), Watkins (P × Wat), and Wyalkatchem (P × Wya). These lines were evaluated in the field for two seasons under limited N supply. The plant sampling was done at anthesis and physiological maturity stages. Various physiological traits were recorded and total N uptake and other N related indices were calculated. The grain protein deviation (GPD) was calculated from the regression of grain yield on GPC. These lines were grouped into different clusters by hierarchical cluster analysis based on grain yield and N-remobilization efficiency (NRE).

Results
The genetic variation in accumulation of biomass at both pre- and post-anthesis stages were correlated with grain-yield. The NRE significantly correlated with aboveground N uptake at anthesis (AGNa) and grain yield but negatively associated with AGN at post-anthesis (AGNpa) suggesting higher N uptake till anthesis favours high N remobilization during grain filling. Hierarchical cluster analysis of these RILs based on NRE and yield resulted in four clusters, efficient (31), moderately efficient (59), moderately inefficient (58), and inefficient (47). In the N-efficient lines, AGNa contributed to 77% of total N accumulated in grains, while it was 63% in N-inefficient lines. Several N-efficient lines also exhibited positive grain protein deviation (GPD), combining high grain yield and GPC. Among crosses, the P × Cim were superior and N-efficient, while P × Wya responded poorly to low N input.

Conclusions
We propose that traits favouring pre- or post-anthesis biomass accumulation and pre-anthesis N uptake may be targeted for breeding to improve grain-yield under limited N. The lines with positive GPD, a first report of genotype-dependent GPD associated with both AGNpa and AGNa in wheat, may be used as varieties or genetic resources to improve grain yield with high GPC for sustainable development under limited N conditions.
Treatment options and their uptake among women with symptoms of perinatal depression: exploratory study in Norway and Portugal
Authors: Fonseca Ana , Branquinho Mariana , Monteiro Fabiana , Araújo-Pedrosa Anabela , Bjørndal Ludvig D. , Lupattelli Angela 
Published: May 2023

Background
Perinatal depression is the most undertreated clinical condition during the perinatal period. Knowledge about women's decision-making in seeking and receiving treatment is scarce.

Aims
To investigate and compare treatment option uptake in perinatal women with depressive symptoms in Portugal and Norway, and to identify sociodemographic and health-related factors associated with treatment uptake.

Method
Participants were women resident in Portugal or Norway (≥18 years) who were pregnant or had given birth in the past 12 months, who presented with active depressive symptoms (Edinburgh Postnatal Depression Scale score ≥10). In an electronic questionnaire, women reported treatment received and sociodemographic and health-related factors.

Results
The sample included 416 women from Portugal and 169 from Norway, of which 79.8% and 53.9%, respectively, were not receiving any treatment. Most Portuguese women were receiving psychological treatment, either alone (45.2%) or combined with pharmacological treatment (21.4%). Most Norwegian participants were receiving only pharmacological (36.5%) or combined treatment (35.4%). Compared with the Portuguese sample, a higher proportion of Norwegian women started treatment before pregnancy (P < 0.001). In Portugal, lower depressive symptoms and self-reported psychopathology were significantly associated with higher likelihood of receiving treatment.

Conclusions
We found that, in both Norway and Portugal, a substantial number of perinatal women with depressive symptoms do not receive any treatment. Differences exist regarding the chosen treatment option and timing of treatment initiation in the two countries. Only mental health-related factors were associated with treatment uptake for perinatal depression in Portugal. Our results highlight the importance of implementing strategies aimed to improve help-seeking behaviours.
Factors Influencing the Experience of Breast and Cervical Cancer Screening Among Women in Low- and Middle-Income Countries: A Systematic Review
Authors: Akoto Edem J. , Allsop Matthew J. 
Published: May 2023

PURPOSE The persistent high morbidity and mortality from breast and cervical cancer in low- and middle-income countries (LMICs) may be influenced by global disparities in the uptake of screening services. This review sought to synthesize existing evidence to determine factors that influence the experience of women relating to breast and cervical screening in LMICs. METHODS A qualitative systematic review of the literature identified through Global Health, Embase, PsycInfo, and MEDLINE. Eligible studies included those outlining primary qualitative research or mixed-method studies with reporting of qualitative findings, detailing women's experiences of involvement with programs for breast or cervical cancer screening. Framework synthesis was used to explore and organize findings from primary qualitative studies and the Critical Appraisal Skills Programme checklist used for quality assessment. RESULTS Database searches yielded 7,264 studies for title and abstract screening and 90 full-text articles for screening, with qualitative data from 17 studies and a total of 722 participants included in this review. Four stages influencing experiences of women were generated across both breast and cervical cancer screening approaches, with individual (eg, knowledge of cancer), social (eg, religion, cultural beliefs), and health system (eg, accessibility) factors identified that influence women's initial and subsequent engagement. CONCLUSION This study synthesizes existing evidence of factors that influence engagement with breast and cervical cancer screening in LMICs. Evidence-informed recommendations are proposed that may improve the experience of cancer screening in LMICs, with further research necessary to explore their operationalization and impact on cancer care delivery.
Glucagon-Like Peptide-1 Is Involved in the Thermic Effects of Dietary Proteins in Male Rodents
Authors: Ochiai Keita , Muto Asuka , Seok Bong Soo , Doi Yuta , Iwasaki Yusaku , Okamatsu-Ogura Yuko , Drucker Daniel J , Hira Tohru 
Published: May 2023

Abstract
Protein intake potently increases body temperature and energy expenditure, but the underlying mechanism thereof remains incompletely understood. Simultaneously, protein intake potently stimulates glucagon-like peptide-1 (GLP-1) secretion. Here, we examined the involvement of GLP-1 in the thermic effects of dietary proteins in rodents by measuring rectal temperature and energy expenditure and modulating GLP-1 signaling. Rectal temperature of rats or mice fasted for 4 or 5 hours were measured using a thermocouple thermometer before and after an oral administration of nutrients. Oxygen consumption after oral protein administration was also measured in rats. Rectal temperature measurements in rats confirmed an increase in core body temperature after refeeding, and the thermic effect of the oral administration of protein was greater than that of a representative carbohydrate or lipid. Among the five dietary proteins examined (casein, whey, rice, egg, and soy), soy protein had the highest thermic effect. The thermic effect of soy protein was also demonstrated by increased oxygen consumption. Studies using a nonselective β-adrenergic receptor antagonist and thermal camera suggested that brown adipose tissue did not contribute to soy protein–induced increase in rectal temperature. Furthermore, the thermic effect of soy protein was completely abolished by antagonism and knockout of the GLP-1 receptor, yet potentiated via augmentation of intact GLP-1 levels through inhibition of dipeptidyl peptidase-4 activity. These results indicate that GLP-1 signaling is essential for the thermic effects of dietary proteins in rats and mice, and extend the metabolic actions of GLP-1 ensuing from nutrient ingestion to encompass the thermic response to ingested protein.
Redefining safety: a narrative review of literature on the underground and open or ‘Dutch’ models of refuge
Authors: Allen Katherine , Adisa Olumide , Hermolle Megan 
Published: May 2023

This article synthesises literature on the evolution of domestic abuse (DA) refuges, with particular attention to the development of two models: the conventional or ‘underground’ refuge (UR) and the open or ‘Dutch’ refuge. The article will detail what the available evidence says about the benefits and drawbacks of these models and explore their implications for the DA sector in England, with reference to extending women’s space for action and meeting the needs of underserved victim-survivors.
The article argues that multiple models of provision are needed to meet the intersecting, complex and at times competing needs of different victim-survivors, and that available evidence provides preliminary support for the viability of the open model as part of a wider suite of responses to DA. Further research is needed to extend the evidence base on the open model, and to develop a whole system approach which can meet the needs of a wider range of victim-survivors.
Experimental development of a gated UV-induced spectroscopic lidar for the daytime study of plant ecology and photosynthesis: multi-modal measurement of fluorescence of trees growing in a field and Mie–Raman–fluorescence of the surrounding atmosphere
Authors: Saito Yasunori , Doi Akira 
Published: May 2023

A gated UV-induced spectroscopic lidar operational during daylight was developed to better understand the plant growth status in real time and the influence from the surrounding atmosphere chemical environment. Initial indoor experiments and short-range (100 m) field measurements were very positive. The lidar worked as a vegetation fluorescence lidar, as well as an atmospheric Mie–Raman–fluorescence lidar. A UV (355 nm) laser was effective to induce fluorescence and Raman scattering, and a synchronous detection technique made it possible to detect weak signals, even in daytime. Tree spectra containing chlorophyll fluorescence of tree leaves offered information about the growth status of trees. Atmospheric spectra containing aerosol Mie scattering, N2, O2, H2O Raman scattering, and pollutant fluorescence helped us to learn about atmospheric circumstances surrounding trees. The multi-modal information is useful for comprehensive understanding of plant ecology.
Aneurysmal subarachnoid hemorrhage in pregnancy: National trends of treatment, predictors, and outcomes
Authors: Khatibi Kasra , Saber Hamidreza , Patel Smit , Mejia Lucido Luciano Ponce , Kaneko Naoki , Szeder Viktor , Nour May , Jahan Reza , Tateshima Satoshi , Colby Geoffrey , Duckwiler Gary , Afshar Yalda 
Published: May 2023

Introduction
Aneurysmal subarachnoid hemorrhage (aSAH) is a rare event associated with significant pregnancy-associated maternal and neonatal morbidity and mortality. The optimal treatment strategy and clinical outcome of aSAH in pregnancy remains unclear. We aimed to investigate the treatment utilizations and outcomes of aSAH in pregnant people.

Methods
Using the 2010–2018 National Inpatient Sample, we identified all birth hospitalizations of women between ages of 18 to 45 associated with subarachnoid hemorrhage and aneurysm treatment were included. Multivariate analyses were used to evaluate the effect of pregnancy state, mode of treatment of aneurysms, severity of subarachnoid hemorrhage on mortality and discharge destination of this cohort. Trends in mode of treatment utilized for aneurysmal treatment in this time interval was evaluated.

Results
13,351 aSAH with treatment were identified, of which 440 were associated with pregnancy. There was no significant difference in mortality or rate of discharge to home in pregnancy related hospitalization. Worse aSAH severity, chronic hypertension, and smaller hospital size was associated with significantly higher rate of mortality from aSAH during pregnancy. Worse aSAH severity was associated with lower rate of discharge to home. Like the non-pregnant cohort, the treatment of ruptured aneurysms in pregnancy are increasingly through endovascular approaches. The mode of treatment does not change the mortality or discharge destination.

Conclusions
Pregnancy does not alter mortality or the discharge destination for aSAH. Ruptured aneurysms during pregnancy are increasingly treated endovascularly. Mode of aneurysm treatment does not affect mortality or discharge destination in pregnancy.
Perinatal mortality rate and adverse perinatal outcomes presumably attributable to placental dysfunction in (near) term gestation: A nationwide 5-year cohort study
Authors: Damhuis Stefanie Elisabeth , Kamphof Hester Dorien , Ravelli Anita C. J. , Gordijn Sanne Jehanne , Ganzevoort Wessel J. 
Published: May 2023

IntroductionPlacental dysfunction can lead to perinatal hypoxic events including stillbirth. Unless there is overt severe fetal growth restriction, placental dysfunction is frequently not identified in (near) term pregnancy, particularly because fetal size is not necessarily small. This study aimed to evaluate, among (near) term births, the burden of hypoxia-related adverse perinatal outcomes reflected in an association with birth weight centiles as a proxy for placental function.Material and methodA nationwide 5-year cohort of the Dutch national birth registry (PeriNed) including 684,938 singleton pregnancies between 36+0and 41+6weeks of gestation. Diabetes, congenital anomalies, chromosomal abnormalities and non-cephalic presentations at delivery were excluded. The main outcome was antenatal mortality rate according to birthweight centiles and gestational age. Secondary outcomes included perinatal hypoxia-related outcomes, including perinatal death and neonatal morbidity, analyzed according to birthweight centiles.ResultsBetween 2015 and 2019, 1,074 perinatal deaths (0.16%) occurred in the study population (n = 684,938), of which 727 (0.10%) antenatally. Of all antenatal- and perinatal deaths, 29.4% and 27.9% occurred in birthweights below the 10thcentile. The incidence of perinatal hypoxia-related outcomes was highest in fetuses with lowest birthweight centiles (18.0%), falling gradually up to the 50thand 90thcentile where the lowest rates of hypoxia-related outcomes (5.4%) were observed.ConclusionPerinatal hypoxia-related events have the highest incidence in the lowest birthweight centiles but are identifiable throughout the entire spectrum. In fact, the majority of the adverse outcome burden in absolute numbers occurs in the group with a birthweight above the 10thcentile. We hypothesize that in most cases these events are attributable to reduced placental function. Additional diagnostic modalities that indicate placental dysfunction at (near) term gestation throughout all birth weight centiles are eagerly wanted.
Tree of Pearls: The Extraordinary Architectural Patronage of the 13th-Century Egyptian Slave-Queen Shajar Al-Durr, D. Fairchild Ruggles (2020)
Authors: Mulder Stephennie 
Published: May 2023

Review of: Tree of Pearls: The Extraordinary Architectural Patronage of the 13th-Century Egyptian Slave-Queen Shajar Al-Durr, D. Fairchild Ruggles (2020)
Oxford: Oxford University Press, 188 pp., 54 b&w and 50 colour illus.,
ISBN: 9780190873202, $35 (cloth)
Mobility and Forced Displacement in the Middle East, Ed. Zahra Babar (2020)
Authors: Hammond Timur 
Published: May 2023

Review of: Mobility and Forced Displacement in the Middle East, Ed. Zahra Babar (2020)
London: C. Hurst & Company, 320 pp., 8 b&w illus.,
ISBN: 9781787383203, £25.00 (paperback)
La Cova de les Dones (Millares, València): el agua subterránea en las prácticas rituales ibéricas
Authors: Machause López Sonia , Falcó Alcázar Joan 
Published: May 2023

El agua jugó un papel vital en las prácticas rituales ibéricas (como origen de vida, purificadora y/o regeneradora). Sin embargo, su implicación en estas prácticas no suele dejar huella en el registro arqueológico. En el caso de las cuevas rituales, su relación es constante, aunque indirecta. En otros contextos mediterráneos se ha valorado este elemento en sus diversos estados (agua en movimiento, estática o solidificada) como un captador simbólico, conocida como “abnormal/unnatural water”. La Cova de les Dones (Millares, València) ha sido objeto de diversas prospecciones arqueológicas y espeleológicas desde los años 60. Estas intervenciones han aportado una gran cantidad de materiales ibéricos, aunque con muy pocas referencias sobre la ubicación y las características generales de los hallazgos. En mayo de 2022, realizamos una prospección que ha permitido ubicar nuevos materiales de cronología ibérica, principalmente caliciformes, en diversos puntos de sus casi 500 metros de recorrido, localizándose generalmente en contacto con formaciones kársticas de diversa índole. Esta cueva es un ejemplo excepcional donde se hallaron casi 200 caliciformes, además de otros recipientes cerámicos, elementos metálicos y restos de fauna, depositados la mayoría de ellos en el interior de gours (actualmente desecados). Dichas evidencias demuestran la relación entre el agua y las ofrendas en este espacio subterráneo frecuentado entre los siglos V-III a. C. Si bien la Cova de les Dones siempre se ha asociado con la esfera ritual, presentamos, por primera vez, un análisis completo de la cueva en época ibérica aproximándonos a su contexto físico y material. Además, valoramos otro tipo de elementos inmateriales que, aunque son complejos de analizar arqueológicamente, nos ayudan a avanzar en la interpretación de estos espacios subterráneos.