bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normative, rational, and relational motives in crosscoalition coordination for a VET refugee programme
Authors: Aerne Annatina , Bonoli Giuliano 
Published: December 2022

AbstractShared beliefs are seen as a basis for policy coordination in the literature. Actors sharing beliefs coordinate their activities in order to translate their beliefs into policies. However, the literature shows that actors also coordinate for policy change across such belief coalitions for diverse reasons. Drawing on the literature on incentives in collective action organisations, we systematise these motives. We argue that rational motivations, such as access to material resources, as well as relational motivations, including power and reputation gains, may convince actors to coordinate. Based on 25 semi-structured expert interviews, we illustrate our propositions with a case study on the motivations that led actors to coordinate and support a vocational education and training (VET) programme for refugees in Switzerland. Coordination between a coalition of VET actors and a coalition of migration actors succeeded despite divergent policy beliefs, mainly due to rational motivations.
Riffing off intellectual property in contemporary dance
Authors: Biagioli-Ravetto Mario , Ravetto-Biagioli Kriss 
Published: December 2022

AbstractDance disappears the moment it becomes visible, the complexity of its ontology matching that of its production and of its intellectual property status. Its creative process is both collaborative and hierarchical, involving the transmission of knowledge from one body to another, remembering steps, recognizing moves, mimicking, and improvising gestures as well as coordinating the roles of dancers, choreographers, and studios. Matthias Sperling’s Riff (2007) directly addresses many of these issues, which inform the specific content of the piece as well as its conceptualization, development, and the copyright licenses that underpin it. Sperling’s performance is clearly conceived as a rite of passage, a dance through which a dancer becomes a choreographer, going from “riffing off” other choreographers’ work to developing dance movements and phrases that, while tied to those of his predecessors, he can claim as his own. As such, Riff makes explicit and rearticulates the rearrangement of professional relations and roles, the difference between reperforming and innovating, between learning from bodies or from media, as well as how the property status of the work intersects with community norms and expectations of attribution.
Making something together: A conversation about creating and sharing dance knowledge
Authors: Davies Siobhan , Leach James 
Published: December 2022

AbstractIn this transcript of an extended interview, Dame Siobhan Davies discusses her biography and oeuvre in the context of an enquiry into aspects of learning, transmission, and claims to ownership over the material that makes modern dance. The creative practice of contemporary dance makers offers an opportunity to describe the “coming into being” of both knowledge and persons in a unique domain, but one also connected to other areas of the arts and collaborative practice. Davies describes an approach to making dance that explicitly rejects two key notions: that the body merely performs what the mind creates and, thus, that the choreographer and the dancer are in a hierarchical relationship of control mirroring the control of mind over matter. She then describes how her creative processes with others have been increasingly shaped to allow non-proprietorial and non-hierarchical outcomes that are substantive to the art works themselves.
Knowing: Dance’s trade literature
Authors: deLahunta Scott 
Published: December 2022

AbstractThis article explores the possibility that dance is a field of expert knowledge that can be studied from the perspective of documents created by dancers and choreographers whose anticipated viewers/readers are mainly other practitioners. These documents include written texts and annotated video recordings created with the aim of sharing processes, techniques and ideas. These documents seek, in a variety of ways, to partially transform experiential knowledge from the tacit/ implicit to the explicit. As such, they suggest a form of trade literature that circulates dance knowledge within its professional network, but with the potential to generate productive exchanges with others outside of this network. By drawing on a number of examples of this trade literature and discussing their methods of circulating dance knowledge, this article makes a link to the theme of this special issue which is dance as a vehicle to discuss and debate ownership and cultural property.
A Trailblazer or a Barrier? Dynastic Politics and Symbolic Representation of the First Female President of South Korea, Park Geun-hye
Authors: Lee Young-Im 
Published: December 2022

AbstractWhat is the impact on symbolic representation of female leaders who are seen as failures? Do women from political dynasties elicit symbolic representation? I answer these questions by analyzing how Park Geun-hye’s election as the first woman president of South Korea and her subsequent impeachment shaped voters’ perceptions of women’s potential and contribution as political leaders. Utilizing an original survey and focus groups, I argue that South Korean voters overall did not recognize Park’s election as the country’s first female president as a symbol of women’s political empowerment because of her dynastic background and her failure to promote women-friendly policies. Although she received credit for being the historic first, women across the political spectrum were concerned that the epic failure of the first female president would reinforce voters’ reluctance to vote for women. This study emphasizes the importance of adopting an intersectional approach in studying symbolic representation.
Explaining Public Support for Gender Quotas: Sexism, Representational Quality, and State Intervention in Japan
Authors: Miura Mari , McElwain Kenneth Mori , Kaneko Tomoki 
Published: December 2022

AbstractElectoral gender quotas remain contentious among many publics. One hurdle is the “principle-policy puzzle”: those who espouse gender egalitarianism may nevertheless oppose affirmative action measures because of disagreements about their necessity and worries about government overreach. Based on an original survey in Japan, where women’s underrepresentation is particularly pronounced, we identify two dimensions that drive attitudes toward quotas. First, modern sexism matters: those who attribute underrepresentation to women’s disinterest or who think that quotas will increase the number of unqualified women candidates are less likely to support quotas. Second, appropriateness matters: those who oppose government intervention in gender affairs are less likely to support quotas. Crucially, these differences hold even among those who desire more women in parliament. Our results suggest that public acceptance of quotas depends more on correcting misperceptions about structural gender barriers and the benign consequences of quotas (“policy”), rather than encouraging people to prefer more women in parliament (“principle”).
Real‐Time Prediction of Alongshore Near‐Field Tsunami Runup Distribution From Heterogeneous Earthquake Slip Distribution
Authors: Lee Jun‐Whan , Irish Jennifer L. , Weiss Robert 
Published: December 2022

AbstractReal‐time tsunami prediction is necessary for tsunami forecasting. Although tsunami forecasting based on a precomputed tsunami simulation database is fast, it is difficult to respond to earthquakes that are not in the database. As the computation speed increases, various alternatives based on physics‐based models have been proposed. However, physics‐based models still require several minutes to simulate tsunamis and can have numerical stability issues that potentially make them unreliable for use in forecasting—particularly in the case of near‐field tsunamis. This paper presents a data‐driven model called the tsunami runup response function for finite faults (TRRF‐FF) model that can predict alongshore near‐field tsunami runup distribution from heterogeneous earthquake slip distribution in less than a second. Once the TRRF‐FF model is trained and calibrated based on a discrete set of tsunami simulations, the TRRF‐FF model can predict alongshore tsunami runup distribution from any combination of finite fault parameters. The TRRF‐FF model treats the leading‐order contribution and the residual part of the alongshore tsunami runup distribution separately. The interaction between finite faults is modeled based on the leading‐order alongshore tsunami runup distribution. We validated the TRRF‐FF modeling approach with more than 200 synthetic tsunami scenarios in eastern Japan. We further explored the performance of the TRRF‐FF model by applying it to the 2011 Tohoku (Japan) tsunami event. The results show that the TRRF‐FF model is more flexible, occupies much less storage space than a precomputed tsunami simulation database, and is more rapid and reliable than real‐time physics‐based numerical simulation.
In-depth analysis of alternative splicing landscape in multiple myeloma and potential role of dysregulated splicing factors
Authors: Aktas Samur Anil , Fulciniti Mariateresa , Avet-Loiseau Herve , Lopez Michael A. , Derebail Sanika , Corre Jill , Minvielle Stephane , Magrangeas Florence , Moreau Philippe , Anderson Kenneth C. , Parmigiani Giovanni , Samur Mehmet K. , Munshi Nikhil C. 
Published: December 2022

AbstractSplicing changes are common in cancer and are associated with dysregulated splicing factors. Here, we analyzed RNA-seq data from 323 newly diagnosed multiple myeloma (MM) patients and described the alternative splicing (AS) landscape. We observed a large number of splicing pattern changes in MM cells compared to normal plasma cells (NPC). The most common events were alterations of mutually exclusive exons and exon skipping. Most of these events were observed in the absence of overall changes in gene expression and often impacted the coding potential of the alternatively spliced genes. To understand the molecular mechanisms driving frequent aberrant AS, we investigated 115 splicing factors (SFs) and associated them with the AS events in MM. We observed that ~40% of SFs were dysregulated in MM cells compared to NPC and found a significant enrichment of SRSF1, SRSF9, and PCB1 binding motifs around AS events. Importantly, SRSF1 overexpression was linked with shorter survival in two independent MM datasets and was correlated with the number of AS events, impacting tumor cell proliferation. Together with the observation that MM cells are vulnerable to splicing inhibition, our results may lay the foundation for developing new therapeutic strategies for MM. We have developed a web portal that allows custom alternative splicing event queries by using gene symbols and visualizes AS events in MM and subgroups. Our portals can be accessed at http://rconnect.dfci.harvard.edu/mmsplicing/ and https://rconnect.dfci.harvard.edu/mmleafcutter/.
Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AMPK/mTOR signaling to induce autophagy
Authors: Deng Yang , Duan Rui , Ding Wangli , Gu Qiuchen , Liu Manman , Zhou Junshan , Sun Jianguo , Zhu Junrong 
Published: December 2022

AbstractAcute ischemic stroke (AIS) is a global cerebrovascular disease with high disability and mortality, which has no effective therapy. Studies have demonstrated that astrocyte-derived exosomes (ADEXs) provided neuroprotection in experimental stroke models. Nevertheless, the role of exosomes derived from oxygen-glucose-deprivation/reoxygenation-stimulated astrocytes (OGD/R-stimulated astrocytes; OGD/R-ADEXs) in AIS remains largely unknown. Here, we found that OGD/R-ADEXs significantly reduced OGD/R-induced neuronal death and promoted neuronal autophagy. These effects were reversed when astrocytes were pretreated with GW4869, an exosome secretion inhibitor, or when hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) was knocked down. Neuroprotection was also observed during treatment with OGD/R-ADEXs in vivo. Further studies showed that Nampt, played a vital effect in the regulation of autophagy, was significantly increased in OGD/R-ADEXs. Knockdown of Nampt in astrocytes abolished the above-mentioned effects of OGD/R-ADEXs. Mechanistically, Nampt increased autophagy and decreased cell death by modulating AMPK/mTOR signaling, which recognized as a key signaling pathway of autophagy after AIS. Collectively, these results showed that Nampt released by OGD/R-ADEXs ameliorated acute ischemic stroke during neuronal injury by targeting AMPK/mTOR signaling to induce autophagy. Our study revealed a new key factor in the secretion of exosomes by OGD/R astrocytes, which regulated autophagy and induced neuroprotection in a mouse stroke model.
The NBDC-DDBJ imputation server facilitates the use of controlled access reference panel datasets in Japan
Authors: Hachiya Tsuyoshi , Ishii Manabu , Kawai Yosuke , Khor Seik-Soon , Kawashima Minae , Toyo-Oka Licht , Mitsuhashi Nobutaka , Fukuda Asami , Kodama Yuichi , Fujisawa Takatomo , Tokunaga Katsushi , Takagi Toshihisa 
Published: December 2022

AbstractAccurate genotype imputation requires large-scale reference panel datasets. When conducting genotype imputation on the Japanese population, researchers can use such datasets under collaborative studies or controlled access conditions in public databases. We developed the NBDC-DDBJ imputation server, which securely provides users with a web user interface to execute genotype imputation on the server. Our benchmarking analysis showed that the accuracy of genotype imputation was improved by leveraging controlled access datasets to increase the number of haplotypes available for analysis compared to using publicly available reference panels such as the 1000 Genomes Project. The NBDC-DDBJ imputation server facilitates the use of controlled access datasets for accurate genotype imputation.
Self-charging electrostatic face masks leveraging triboelectrification for prolonged air filtration
Authors: Peng Zehua , Shi Jihong , Xiao Xiao , Hong Ying , Li Xuemu , Zhang Weiwei , Cheng Yongliang , Wang Zuankai , Li Wen Jung , Chen Jun , Leung Michael K. H. , Yang Zhengbao 
Published: December 2022

AbstractElectrostatic adsorption is an important complement to the mechanical filtration for high-efficiency air filtering. However, the electrostatic charge decays with time, especially in humid conditions. In this work, a self-charging air filter is presented to capture airborne particles in an efficient and long-lasting manner without the need of external power sources. Leveraging the triboelectric effect between the electrospun poly(vinylidene fluoride) nanofiber film and nylon fabric, the self-charging air filter-based mask excited by breathing can continuously replenish electrostatic charges. As a result, its effective lifespan is up to 60 hours (including 30 hours of wearing), with a minimum filtration efficiency of 95.8% for 0.3-μm particles. The filtration efficiency and lifespan are significantly higher than those of a commercial surgical mask. Furthermore, we uncover the quantitative relation between filtration efficiency and surface electrostatic potential. This work provides an effective strategy to significantly prolong the electrostatic adsorption efficacy for high-performance air-filtering masks.
Histology-based survival outcomes in hormone receptor-positive metastatic breast cancer treated with targeted therapies
Authors: Mouabbi Jason A. , Raghavendra Akshara Singareeka , Bassett Roland L. , Hassan Amy , Tripathy Debu , Layman Rachel M. 
Published: December 2022

AbstractThe addition of targeted therapies (TT) to endocrine therapy (ET) has improved the outcomes of patients with HR-positive, HER2-negative metastatic breast cancer (mBC). However, it is unknown whether patients with invasive lobular carcinoma (ILC) or mixed invasive ductal and lobular carcinoma (mixed) histologies experience the same magnitude of benefit from this therapy as those with invasive ductal carcinoma (IDC). We aim to determine whether patients with IDC, ILC, and mixed HR+/HER2− mBC derive similar benefit from the addition of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6is), mammalian target of rapamycin inhibitor (mTORi), and phosphoinositide 3-kinase inhibitor (PI3Ki) to ET in HR+/HER2− mBC. We conducted an observational, population-based investigation using data from the MD Anderson prospectively collected database. We conducted a histology-based analysis of progression-free survival (PFS) and overall survival (OS) durations in 3784 patients with HR+/HER2− mBC who were treated with TT plus ET between January 1, 2010, and December 31, 2021. Out of the 3784 patients, 2975 were included in the final analysis. Of these, 2249 received CDK4/6is (81% IDC, 15% ILC, and 4% mixed), 1027 received everolimus (82% IDC, 14% ILC, and 4% mixed) and 49 received alpelisib (81% IDC and 19% ILC). The addition of targeted therapy to ET did not result in statistically significant differences in PFS or OS duration among patients with IDC, ILC, and mixed HR+/HER2− mBC. We concluded that for patients with HR+/HER2− mBC, the addition of TT to ET leads to a similar magnitude of benefit, irrespective of histology.
Fluxomics reveals cellular and molecular basis of increased renal ammoniagenesis
Authors: Mpabanzi Liliane , Wainwright Jessica , Boonen Bas , van Eijk Hans , Dhar Dipok , Karssemeijer Esther , Dejong Cees H. C. , Jalan Rajiv , Schwartz Jean-Marc , Olde Damink Steven W. M. , Soons Zita 
Published: December 2022

AbstractThe kidney plays a critical role in excreting ammonia during metabolic acidosis and liver failure. The mechanisms behind this process have been poorly explored. The present study combines results of in vivo experiments of increased total ammoniagenesis with systems biology modeling, in which eight rats were fed an amino acid-rich diet (HD group) and eight a normal chow diet (AL group). We developed a method based on elementary mode analysis to study changes in amino acid flux occurring across the kidney in increased ammoniagenesis. Elementary modes represent minimal feasible metabolic paths in steady state. The model was used to predict amino acid fluxes in healthy and pre-hyperammonemic conditions, which were compared to experimental fluxes in rats. First, we found that total renal ammoniagenesis increased from 264 ± 68 to 612 ± 87 nmol (100 g body weight)−1 min−1 in the HD group (P = 0.021) and a concomitated upregulation of NKCC2 ammonia and other transporters in the kidney. In the kidney metabolic model, the best predictions were obtained with ammonia transport as an objective. Other objectives resulting in a fair correlation with the measured fluxes (correlation coefficient >0.5) were growth, protein uptake, urea excretion, and lysine and phenylalanine transport. These predictions were improved when specific gene expression data were considered in HD conditions, suggesting a role for the mitochondrial glycine pathway. Further studies are needed to determine if regulation through the mitochondrial glycine pathway and ammonia transporters can be modulated and how to use the kidney as a therapeutic target in hyperammonemia.
Game theoretical trajectory planning enhances social acceptability of robots by humans
Authors: Galati Giada , Primatesta Stefano , Grammatico Sergio , Macrì Simone , Rizzo Alessandro 
Published: December 2022

AbstractSince humans and robots are increasingly sharing portions of their operational spaces, experimental evidence is needed to ascertain the safety and social acceptability of robots in human-populated environments. Although several studies have aimed at devising strategies for robot trajectory planning to performsafemotion in populated environments, a few efforts havemeasuredto what extent a robot trajectory isacceptedby humans. Here, we present a navigation system for autonomous robots that ensures safety and social acceptability of robotic trajectories. We overcome the typical reactive nature of state-of-the-art trajectory planners by leveraging non-cooperative game theory to design a planner that encapsulates human-like features of preservation of a personal space, recognition of groups, sequential and strategized decision making, and smooth obstacle avoidance. Social acceptability is measured through a variation of the Turing test administered in the form of a survey questionnaire to a pool of 691 participants. Comparison terms for our tests are a state-of-the-art navigation algorithm (Enhanced Vector Field Histogram, VFH) and purely human trajectories. While all participants easily recognized the non-human nature of VFH-generated trajectories, the distinction between game-theoretical trajectories and human ones were hardly revealed. Our results mark a strong milestone toward the full integration of robots in social environments.
Variability in surveillance practice for patients with diagnosis of bicuspid aortic valve syndrome
Authors: Kahler-Quesada Arianna M. , Vallabhajosyula Ishani , Yousef Sameh , Mori Makoto , Amabile Andrea , Assi Roland , Geirsson Arnar , Vallabhajosyula Prashanth 
Published: December 2022

AbstractIn patients with bicuspid aortic valves, guidelines call for regular follow-up to monitor disease progression and guide intervention. We aimed to evaluate how closely these recommendations are followed at a tertiary care center. Among 48,504 patients who received echocardiograms (2013–2018) at a tertiary care center, 245 patients were identified to have bicuspid aortic valve. Bivariate analyses compared characteristics between patients who did and did not receive follow-up by a cardiovascular specialist. During a median follow-up of 3.5 ± 2.2 years (mean age 55.2 ± 15.6 years, 30.2% female), 72.7% of patients had at least one visit with a cardiovascular specialist after diagnosis of bicuspid aortic valve. These patients had a higher proportion of surveillance by echocardiogram (78.7% vs. 34.3%, p < .0001), CT or MRI (41.0% vs. 3.0%, p < .0001), and were more likely to undergo surgery. Patients with moderate-severe valvular or aortic pathology were not more likely to be followed by a specialist or receive follow-up echocardiograms. Follow-up care for patients with bicuspid aortic valve was highly variable, and surveillance imaging was sparse despite guidelines. There is an urgent need for mechanisms to monitor this population with increased risk of progressive valvulopathy and aortopathy.
Soil fertility analysis in the Republic of Bashkortostan
Authors: Mirsayapov Ramil , Asylbaev Ilgiz , Kiseleva Anna , Minkina Tatiana , Kurmasheva Nadezhda 
Published: December 2022

AbstractThe manuscript presents the materials of soil fertility analysis of agricultural lands in the north-eastern forest-steppe of the Republic of Bashkortostan in the conditions of the Salavatskiy district of the republic (Russian Federation). Agrochemical analysis of the humus accumulation, mobile phosphorus, exchangeable potassium was carried out, morphological properties were studied, the thickness of the humus horizon, granulometric composition and soil erosion were determined. During the 49-year period of agricultural land use, it was revealed some of the medium-humus soils passed into the category of high-humus, caused by the fact that the arable lands were not used for cultivating crops and they were withdrawn from circulation and sown with many-year-old grasses. As to the thickness of the humus horizon, low-yielding soils predominate, which occupy 60.11%, average 32.9%. The main land area belongs to slightly washed soils of 67,445.2 ha (58.2%) and unwashed 36,985.5 ha (31.9%). Agricultural lands are mainly characterized as medium-humus (80.3%) and obese (12.1%) ones. Based on the results of the research, an adjustment, digitization and a new soil map of the Salavatskiy district was made with the allocation of the main types and subtypes of soils with the indication of varieties on a scale of 1:25,000.