bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extractive spectrophotometric detection of Sn(II) using 6-bromo-3-hydroxy-2- (5-methylfuran-2-yl)-4H-chromen-4-one
Authors: Bhatia Pankaj , . Virender , Sharma Harish Kumar , Singh Gurjaspreet , Mohan Brij 
Published: June 2023

Abstract
For the determination of tin(II) traces, an extractive spectrophotometric approach is devised. The applied method serves a powerful tool for determination of tin(II), involves the formation of yellow colored complex among the 6-bromo-3-hydroxy-2-(5-methylfuran-2-yl)-4H-chromen-4-one (BHMF) and tin(II) in 1:2 stiochiometry in a slightly acidic medium (HCl). The complex shows absorbance at 434 nm in respect of the blank reagent. The outcomes of spectral investigation for complexation showed a Beer’s range of 0-1.3 µg Sn mL− 1, molar absorptivity, specific absorptivity and Sandell’s complex sensitivity are 9.291 × 104 L mol− 1cm− 1, 0.490 mL g− 1cm− 1 and 0.002040 µg cm− 2 at 434 nm and stable for up to two days.The interferences studyresults showed that this method is free from interferences, when tested with metal ions including Ag,Be, Bi, Ca,Cd, Ce, Co,Hg, Mo,Re,Pt, Se,Ti,U,V, W and other common cations, anions, and complexing agents. The method is quite simple, highly selective, and sensitive with good re-producibility. The method has been satisfactorily by utilizing the proposed procedure, and its applicability has been tested by analyzing synthetic samples and an alloy sample of gunmetal. The procedure assumes this because of the scarcity of better methods for determining tin(II). The results are in good agreement with the certified value.
Control of Metal Oxides’Electronic Conductivity Through Visual Intercalation Chemical Reactions
Authors: Zhang Yuanyuan , Zhang Xiaohua , Pang Quanquan , Yan Jianhua 
Published: June 2023

Abstract
Cation intercalation is an effective method to optimize the electronic structures of metal oxides, but manipulating the intercalation structure and conductivity is difficult. Here, we report a visual topochemical synthesis strategy to control the intercalation pathways, structures, and conductivity, and realize rapid synthesis of flexible conductive metal oxide films in 1 min at room-temperature. This study uses a flexible topological TiO2 nanofiber film as the prototype and designs three different charge-driven models to intercalate the preset Li+-ions into the TiO2 lattice slowly (µm/s), rapidly (mm/s) or ultrafast (cm/s). The Li+-intercalation causes real-time color changes of the TiO2 films from white to blue and then black, corresponding to the new structures of blue LixTiO2 and black TiO2-δ derived in TiO2, and the enhanced conductivity from 0 to 1 and 40 S/m. This work realizes the rapid synthesis of flexible TiO2 nanofiber films with tunable conductivity on large-scale and has been extended to synthesize other conductive metal oxide films for appealing applications in fast-charge electrodes, electrochromic pattern designs, catalysis and so on.
Early Detection of Heart Disease Based on Medical Check-Up Datasets Using Multilayer Perceptron Classifier
Authors: Rahman Ben , Sabarguna Boy Subirosa , Warnars Hendric Spits , Budiharto Widodo 
Published: June 2023

Abstract

BackgroundHeart disease is a leading cause of mortality worldwide, including in Indonesia. With millions of deaths attributed to heart disease annually, early detection and prevention are essential in reducing its impact. This study aims to address the issue of late diagnosis by focusing on early detection and monitoring of heart disease symptoms. Risk factors such as high blood pressure, high cholesterol, smoking, obesity, and sedentary lifestyle contribute to the development of heart disease.FindingsMany patients with heart disease are diagnosed at advanced stages, indicating a lack of timely detection. To overcome this, the study utilizes Medical Check-Up Datasets and applies the Multilayer Perceptron (MLP) Classifier with back-propagation for early diagnosis. The MLP Classifier employs supervised learning during training and testing, where a value of 1 represents abnormal (presence of heart disease) and 0 represents normal (absence of heart disease). The study achieves an accuracy of 99.2% in early detection.ConclusionThe findings of this study demonstrate the feasibility and significance of early detection in heart disease diagnosis. By using the MLP Classifier, healthcare providers can promptly identify and address heart disease symptoms, enabling appropriate treatment planning and reducing the risk of complications. These results provide valuable insights for healthcare professionals, contributing to improved patient care and outcomes.
Seasonal Drivers of Nutrient Concentration in Lake Ecosystems: Evaluating Climate and Ice Phenology Characteristics in a Shallow Eutrophic Lake
Authors: Julian Paul , Husk Barry , Baulch Helen , Simon Dana F , Tromas Nicolas , Sauve Sébastien 
Published: June 2023

Abstract
The climate is shifting across the globe and understanding seasonal drivers of nutrient concentration in lake ecosystems is important to further our understanding of drivers of biotic change. Additionally, the degree to which winter dynamics in lake ecosystems respond to climate and ecosystem level factors and their role in influencing nutrient cycling processes is unclear but important for understanding and managing potential changes. The overall objective of this study was to evaluate seasonal water column nutrient concentrations, climatic conditions, and ice phenology characteristics in a small shallow eutrophic lake. Water column nutrients were sampled from October 2009 to September 2020 at two locations at Petit-lac-Saint-François (Lake Inlet and Lake Outlet) in south-central Quebec, Canada. During this sampling period, ice phenology characteristics and phytoplankton samples were also collected. The degree of correlation with nutrient concentrations varied between climate indices across different time scales and monitoring locations. The timing of lake ice varied during the study period ranging from 102 to 166 days of ice coverage with the duration of ice coverage being significantly correlated with dissolved inorganic nutrient accumulation during the ice-on period. Moreover, phytoplankton composition varied between ice-on/off periods and species richness significantly declined. Studies that evaluate winter limnological characteristics are limited but important to understand the seasonal dynamics of nutrient cycling in these systems, especially given how the climate is shifting. Moreover, the climate is a significant driver of lake biogeochemical with respect to both inputs and internal processes.
How does the clinical practice of Aotearoa New Zealand podiatrists align with international guidelines for the prevention of diabetes-related foot disease? a cross-sectional survey
Authors: Jepson Hannah , Lazzarini Peter A , Garrett Michele , Carroll Matthew 
Published: June 2023

Abstract
Background
Given the importance of preventive care for the lower limb in people with diabetes, and the absence of local guidelines in Aotearoa New Zealand (NZ), the aim of this study was to determine the alignment of assessment and management used in the prevention of diabetes-related foot disease by NZ podiatrists to the international prevention guideline recommendations.
Methods
A 37-item web-based survey was developed using a 5-point Likert scale (0 = always; 5 = never) based on the International Working Group of the Diabetic Foot (IWGDF) 2019 prevention guidelines and included domains on participant demographics, sector, caseloads, guidelines, screening, management, education, and referral. The survey was distributed to NZ podiatrists through the NZ podiatry association and social media. Participants completing > 50% of items were included. The Mann-Whitney U test was used to examine differences between sector subgroups.
Results
Seventy-seven responses (16.3% of the NZ workforce) were received, of which 52 completed > 50% of items and were included. Of those 52 podiatrists, 73% were from the private sector. Public sector podiatrists reported higher weekly caseloads of patients with diabetes (p = 0.03) and foot ulcers (p < 0.001). The NZSSD risk stratification system and IWGDF guidelines were the two most frequently utilised guidance documents. Participants reported median scores of at least “often” (< 2) for all items in the assessment and management, inspection, examination, and education provision domains for people with a high-risk foot. More than 50% of respondents reported screening more frequently than guideline recommendations for people with a very low to moderate risk foot. Structured education program was only used by 4 (5%) participants. Public sector podiatrists reported greater provision of custom-made footwear (p = 0.04) and multi-disciplinary team care (p = 0.03).
Conclusion
NZ podiatrists generally follow international guideline recommendations with respect to screening, self-care education, appropriate footwear, and treatment of risk factors for people at-risk of diabetes-related foot disease. However there may be over-screening of people with very low to medium risk occurring in clinical practice. Increasing access to integrated healthcare, custom-made footwear and structured educational programmes appear to be areas of practice that could be developed in future to help prevent diabetes-related foot disease in NZ.
Alien flora of Nigeria: taxonomy, biogeography, habitats, and ecological impacts
Authors: Borokini Israel , Kortz Alessandra , Anibaba Quadri , Witt Arne , Aigbokhan Emmanuel , Hejda Martin , Pyšek Petr 
Published: June 2023

Abstract
Biological invasions remain one of the greatest threats to biodiversity and livelihoods, and this is predicted to increase due to climate change and globalization. In this study, we produced a comprehensive checklist of alien plants in Nigeria from online flora databases, herbarium records, published field surveys, and questionnaires administered to botanical gardens. The resulting alien flora was classified into naturalized, invasive, and cultivated plants. We then fitted a random forest model to identify the attributes which facilitate the naturalization of alien plants in Nigeria. We also used separate chi-squared tests to investigate if the frequency of these attributes is statistically significant between the naturalized and invasive plants. The results include 1,381 alien plant taxa, comprising 238 naturalized, 190 invasive, and 953 cultivated species. The naturalized and invasive plants (428 species) spread across 91 families, with Fabaceae and Poaceae having the highest representations. The random forest model showed that life forms and local economic uses were the most important drivers of alien plant naturalization in Nigeria. Chi-squared tests revealed a non-random distribution of life forms (P < 0.001), higher frequencies of naturalized plants from the Indomalaya (P = 0.006) and the Neotropics (P = 0.04), greater introductions during the British colonial rule, and are used mostly for medicinal, ornamental, food, and fodder. Naturalized and invasive plants were recorded in all regions of Nigeria and are mostly found in urban ruderal and agricultural landscapes. This baseline information can support further ecological studies and conservation actions in Nigeria.
Simulation of urban flood process based on a hybrid LSTM-SWMM model
Authors: zhao chenchen , Liu chengshuai , Li wenzhong , Tang yehai , Yang fan , Xu yingying , Quan liyu , Hu caihong 
Published: June 2023

Abstract
This study proposes a novel hybrid LSTM-SWMM model that integrates the advantages of SWMM model and the LSTM neural network for the first time to predict runoff in urban areas. The aim is to build an efficient and rapid model that takes into account the physical mechanism, so as to better respond to and simulate urban flood. The results show that, in the training period and testing period, the simulated discharge process of LSTM-SWMM model and the observed discharge process are in good agreement, which can reflect the actual rainfall runoff process. The R² of LSTM-SWMM model is 0.969, and the R² of LSTM model is 0.954. Also, when the forecasting period is 1, the NSE value of LSTM-SWMM is 0.967, which is the best forecasting accuracy; when the forecasting period is 6, the NSE value of LSTM-SWMM is 0.939, which is the worst. With the increase of the forecasting period, the NSE values show a downward trend, and the accuracy gradually decreases.
Shuangshen Ningxin Capsule alleviates myocardial ischemia-reperfusion injury in miniature pigs by modulating mitophagy:network pharmacology and experiments in vivo
Authors: Jia Feifan , Chen Yuanyuan , Xin Gaojie , Li Lingmei , Liu Zixin , Xu Sujuan , Gao Jiaming , Meng Hongxu , Shi Yue , Ma Yanlei , Li Lei , Fu Jianhua 
Published: June 2023

Abstract
Background:Myocardial ischemia/reperfusion injury (MI/RI) is a common pathological basis for several cardiovascular diseases, for which no effective treatment exists. Shuangshen Ningxin (SSNX) capsule which is developed by Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine has been demonstrated to alleviate MI/RI, but its mechanism remains to be further elucidated.
Methods: The MI/RI miniature pigs model was constructed to evaluate the pharmacodynamics of SSNX by blocking the proximal blood flow of the left anterior descending branch of the cardiac coronary artery through an interventional balloon. The major chemical compounds and potential targets of SSNX were screened by HPLC-MS and SwissTargetPrediction. The targets of MI/RI were identified based on Online Mendelian Inheritance in Man(OMIM) and GeneCards. Cytoscape 3.9.0 was applied to construct a protein-protein interaction (PPI) network, and Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using metascape. To further validate the mechanism of SSNX, Molecular docking, Transmission electron microscopy, and Western blot analysis were used to test the effectiveness of targets in related pathways.
Results:The result of experiment in vivo confirmed that SSNX significantly improved cardiac function, attenuated myocardial I/R injury. Through network analysis, a total of 15 active components and 201 targets were obtained from SSNX, 75 of which are potential targets for the treatment of MI/RI. KEGG and MCODE analysis showed that SSNX is involved in the mitophagy signaling pathway, and ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Rb2 are key components associated with the mitophagy. Further experimental results proved that SSNX protected mitochondrial structure and function, and significantly reduced the expression of mitophagy-related proteins PINK1, Parkin, FUNDC1 and BNIP3 in MI/RI miniature pigs.
Conclusion:In this study, the integration of network pharmacology and experiments in vivo demonstrated that SSNX interfered with MI/RI by inhibiting mitophagy.
Use of the Perceived Stress Scale in Russian Adolescents: Factor Structure and Psychometric Properties
Authors: Marakshina Julia , Adamovich Timofey , Vasin Georgy , Ismatullina Victoria , Lobaskova Marina , Malykh Artem , Kolyasnikov Pavel , Tabueva Anna , Zakharov Ilia , Malykh Sergey 
Published: June 2023

Abstract
This study involved a psychometric analysis of the 10-item Perceived Stress Scale (PSS-10). To investigate the Russian version of the PSS-10 for adolescents, 3530 adolescents aged 13 to 17 years were recruited. Confirmatory factor analysis revealed that the data corresponded to the expected two-factor configuration. Psychometric properties and factor structure were evaluated. As expected, the PSS-10 included two factors: perceived helplessness and perceived self-efficacy. Internal consistency demonstrated acceptable values (Cronbach’s alpha was 0.82 for perceived distress, 0.77 for perceived self-efficacy, and 0.80 for the overall PSS score). Measurement invariance across sexes was assessed, and configural and metric invariance were confirmed. The developed diagnostic tool can be used both in the school system to alleviate the negative consequences of academic stress in adolescents and, in the future, in other areas, particularly in clinical practice.
Non-Invasive Microwave Sensor Design for Real-Time Continuous Dehydration Monitoring
Authors: Baghelani Masoud , Abbasi Zahra , Daneshmand Mojgan , Light Peter E. 
Published: June 2023

Abstract
The accurate assessment of dehydration is crucial in many diverse clinical applications. Currently used methods for assessing dehydration rely on either skin pinch tests or analysis of urine. Therefore, therefore is a need for wearable non-invasive devices for continuous dehydration monitoring. This paper presents a novel sensor design for the monitoring of dehydration levels by the use of chipless microwave resonators. The sensor design incorporates a metallic layer beyond the tag sensor itself, resulting in an isolation of the dehydration sensing system from conflicting ambient signals that provides a targeted sensing system to the tissue itself with reduced interference. The sensitivity of the sensor is high, with a ~100 KHz shift for a 1% change in dehydration).
De novo biosynthesis of 2-hydroxyterephthalic acid, the monomer for high-performance hydroxyl modified PBO fiber, by enzymatic Kolbe- Schmitt reaction with CO2 fixation
Authors: Zhou Yali , Zhang Shiding , Huang Shiming , Fan Xuanhe , Su Haijia , Tan Tianwei 
Published: June 2023

Abstract
Background
High-performance poly(p-phenylenebenzobisoxazole) (PBO) fiber, with excellent mechanical properties (stiffness, strength, and toughness), high thermal stability combined and light weight, are widely employed in automotive and aerospace composites, body armor and sports goods. Hydroxyl modified PBO (HPBO) fiber shows better photostability and interfacial shear strength. 2-Hydroxyterephthalic acid (2-HTA), the monomer for the HPBO fiber, is usually synthesized by chemical method, which has poor space selectivity and high energy consumption. The enzymatic Kolbe-Schmitt reaction, which carboxylates phenolic substrates to generate hydroxybenzoic acids with bicarbonate/CO2, was applied in de novo biosynthesis of 2-HTA with CO2 fixation.
Results
The biosynthesis of 2-HTA was achieved by the innovative application of hydroxybenzoic acid (de)carboxylases to carboxylation of 3-hydroxybenzoic acid (3-HBA) at the para-position of the benzene carboxyl group, known as enzymatic Kolbe-Schmitt reaction. Three hydroxybenzoic acid (de)carboxylases from diverse microorganisms were expressed in recombinant E. coli. 2,3-Dihydroxybenzoic acid decarboxylase from Aspergillus oryzae (2,3-DHBD_Ao) showed highest activity. In addition, two amino acid substitutions, F27G and T62A, proved to be of great help in improving 2,3-DHBD activity. The double site mutation F27G/T62A increased the production of 2-HTA by 28-fold up to 5.87 ± 0.06 mg/L in vitro. Moreover, de novo biosynthetic pathway of 2-HTA was constructed by co-expression of 2,3-DHBD_Ao and 3-hydroxybenzoate synthase Hyg5 in S. cerevisiae S288C with Ura3, Aro7 and Trp3 knockout. The engineered strain synthesized 45.4 ± 0.2 µg/L 2-HTA at 36 h in the CO2 environment.
Conclusion
De novo synthesis of 2-HTA has been achieved, which uses glucose as a raw material to generate shikimic acid, chorismic acid, and 3-HBA, and finally obtains 2-HTA. We demonstrate the strong potential of hydroxybenzoate (de)carboxylase to produce terephthalic acid and its derivatives with CO2 fixation.
Novel frameshift Variant c.3056delA of the DHX38 Gene in a Chinese Family With Retinitis Pigmentosa
Authors: Zhang Sinan , Xu Yulei , Zhu Haonan , Liu Xuling , Hong Xutao , Qi Ming , Jin Xin , Liang Jie 
Published: June 2023

Abstract
Background Retinitis pigmentosa (RP) is the most common inherited retinal degeneration. Our purpose was to describe disease-causing variants in a Chinese patient with RP. We described the clinical features and identify a novel (p.Lys1019fs) variant in DHX38.Case presentation A 47-year-old Chinese man complained of persistent visual impairment. To clarify the diagnosis, the clinical symptoms were observed and analysed in combination with comprehensive ophthalmologic examinations and genetic analysis. Abnormal fundus manifestations were found, including thinning of retinal arteriovenous vessels, obscure reflection in macular fovea, and scattered osteocyte-like pigment in the retina. We identified two mutations of USH2A gene (c.2802T > G and c.8559-2A > G ) and one novel mutation of DHX38 gene (c.3056delA) in the proband. The parents with visual loss were heterozygous carriers. The compound heterozygous mutations in USH2A are the underlying cause of this case. And the novel variant results in the mutation of amino acid 1019 from lysine to arginine and bring a new reading frame, the 37th codon followed by the mutation site turn to be a stop codon, resulting in a premature protein truncation.Conclusions The study identified two compound heterozygous USH2A variants (c.2802T > G and c.8559-2A > G) and one novel DHX38 variants (c.3056delA) in an RP patient. It is conducive to a clearer understanding of genotype-phenotype correlation in the non-syndromic RP patients. Our study expands the spectrum of DHX38 variants in RP as well.
Resilience, Sense of Danger and Reporting for Work in Wartime in Healthcare Personnel in a General Hospital
Authors: Cohen Sarah Sberro , Amit Inbal , Barenboim Erez , Roitman Alona 
Published: June 2023

Abstract
Background & Aims: During wartime, front line hospitals must not only continue to maintain their range of services and high standards of care, including during missile attacks, but also ensure that their healthcare personnel (HCP) maintain their attendance.
This study was designed to identify the factors affecting the percentage of HCPs reporting for work during periods of security escalations and wartime. Specifically, it explored the relationships between resilience, sense of danger and HCP absenteeism. The results can contribute to designing an intervention to decrease HCP absenteeism during security escalations, wartime and emergencies.
Methods: A cross-sectional study was conducted from December 2021 to January 2022. An online questionnaire was sent to the HCP of a southern Israeli general hospital located on the front lines of a longstanding conflict. Resilience was measured on the Conor-Davidson scale (CD-RISC). Sense of danger was evaluated on the Solomon & Prager inventory.
Results: In total, 390 employees completed the survey. Of this sample, 77.4% reported fully to work during the last security escalations in May 2021. Most of the sample (84.1%) felt insecure on the way to work. The HCP who reported fully to work had a higher level of resilience than employees who reported partially or did not come to work at all (p = 0.03). A higher sense of danger in the workplace correlated with a 73% increase in absenteeism (p < 0.01). Absenteeism (partial or full) was higher among HCP with children who require supervision (p < 0.01). Hospital preparedness for emergencies increased HCP attendance at work (p = 0.03).
Conclusions: Hospital management should design programs to strengthen the level of resilience and the sense of security of hospital personnel to encourage greater attendance at work in wartime, crises, or emergencies.