bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Audit of External Referrals to the Periodontology Department in an Irish University Dental Hospital
Authors: O'Meara Conor , Duncan Henry F , Harrison Peter 
Published: January 2023

##Statement of Problem: Concerns were raised that referrals to the Dublin Dental University Hospital (DDUH) Periodontology Department often lacked sufficient information for triaging. ##Purpose of the Study: To investigate the quality of periodontal referrals when compared with a local standard and examine if the use of the existing divisional referral proforma was associated with a higher standard of referral. ##Materials and methods: Data was collected by retrospectively auditing 150 external referrals to the DDUH Periodontology Department at representative intervals over a 12-month period. Referrals were assessed to investigate if they included 22 information points as requested by our local standard (referral proforma). Data was input into a Microsoft Excel spreadsheet and analysed. Ten periodontal referrals proforma from similar Dental Institutes across Ireland and the UK were also compared to our proforma to investigate if our institution requests a similar level of information to others. ##Results: Referral analysis indicated that clinicians provided on average 12.9 out of 22 (59%) items of required information in their referral correspondence. Referrers utilised the appropriate referral proforma in 28% of cases. Use of this proforma was associated with a better standard of referral (17.9 out of 22 required information items provided, 80%) when compared with non-proforma referrals (11.2 out of 22 required information items provided, 51%). Analysis of other institutions’ proforma highlighted that DDUH requests referring practitioners to include more information than equivalent peer institutions. ##Conclusion: Periodontal referral letters to DDUH frequently fail to include sufficient information. Practitioners seldom utilise the divisional referral proforma, although its use is associated with improved referral quality. Simplification of the existing referral proforma and dissemination of referral guidelines to practitioners is recommended moving forward.
Dens Invaginatus and the Paediatric Dental Patient: Two Case Reports
Authors: O'Dowling Keane Shane , Lucey Siobhán , Quilligan Graham 
Published: January 2023

##Background Dens Invaginatus (DI) in paediatric patients presents a challenge in treatment planning, patient management and potentially complex endodontic treatment. DI has been reported to be as prevalent as 0.3% to 10% in permanent teeth. Clinicians may be challenged in managing both the patient and the dental anomaly. ##Aims The aim of these case reports is to highlight the presenting features of DI, treatment strategies and to highlight the need for a national clinical care pathway for children affected by dental anomalies such as DI, in addition to complex traumatic dental injuries and developmental defects of enamel and dentine. ##Conclusions Awareness of the clinical features and early identification of teeth affected by DI can allow for prevention, minimally invasive management, and where necessary, appropriate referral for specialist management of these cases. Sealing the palatal surfaces of young permanent incisors can limit the sequelae of pulpal necrosis in teeth with DI. Teeth with DI and complex anatomical presentation are predisposed to pulpal pathology and restorative management can be extremely challenging. Currently there are limited referral options for General Dental Practitioners who identify cases of DI in primary care settings in Ireland. This may lead to delayed treatment, prolonged symptoms and suboptimal outcomes for patients. A national clinical care pathway is recommended.
Burnout, estrés y autoestima sobre el rendimiento académico en universitarios del área de la salud
Authors: Torres-Zapata Ángel Esteban , Torres-Zapata Angela , Acuña-Lara Juana Patricia , Moguel-Ceballos Juan Eduardo , Brito-Cruz Teresa del Jesús 
Published: January 2023

A las instituciones educativas les resulta útil medir el rendimiento académico de los estudiantes para saber el alcance de los objetivos educativos, sin embargo, este puede estar afectado por diversos factores, como el burnout académico, estrés académico y baja autoestima del estudiante. El presente trabajo plantea como objetivo, describir el estado actual del conocimiento sobre el efecto del burnout académico, estrés académico o autoestima deteriorada, sobre el rendimiento académico en estudiantes de pregrado del área de la salud; los resultados permitirán generar estrategias de intervención desde la acción tutorial. Los estudiantes universitarios del área de la salud, deben poseer un adecuado bienestar, incluyendo el aspecto mental, ya que estos individuos precisan brindar servicio a la comunidad; algunas de las características en estas licenciaturas son la seguridad y confianza en sí mismo para tomar decisiones, por esta razón, es fundamental apuntalar en la detección oportuna del estrés, burnout y desarrollo de la autoestima en los estudiantes para evitar en la medida de lo posible la depresión, ansiedad, angustia y adicciones, de lo contrario, los alumnos no podrán sostener la carga académica y profesional o hacer frente de manera adecuada a los obstáculos que se presenten en el camino médico asistencial.
Palabras clave:
Burnout, estrés, autoestima, rendimiento académico.

ABSTRACT
Educational institutions find it useful to measure the academic performance of students to know the scope of educational objectives, however, this may be affected by various factors, such as academic burnout, academic stress and low student self-esteem. The objective of this work is to describe the current state of knowledge on the effect of academic burnout, academic stress or impaired self-esteem, on academic performance in undergraduate students in the health area; The results will allow generating intervention strategies from the tutorial action. University students in the area of ​​health must have adequate well-being, including the mental aspect, since these individuals need to provide service to the community; Some of the characteristics in these degrees are security and self-confidence to make decisions, for this reason, it is essential to support the timely detection of stress, burnout and development of self-esteem in students to avoid as far as possible depression, anxiety, anguish and addictions, otherwise, students will not be able to sustain the academic and professional load or adequately face the obstacles that arise in the medical care path.
Keywords:
Burnout, stress, self-esteem, academic performance.
Programa de acondicionamiento físico para la mejorar la fuerza en mujeres de 30 a 39 años en Ciudad del Carmen, México
Authors: Zaleta-Morales Lorena , Ruíz-Campos Verónica B. , Blanco-del Valle Aarón 
Published: January 2023

En la investigación se elabora un programa de acondicionamiento físico mediante el cual se desarrollan las capacidades físicas para una mejora de la calidad de vida en mujeres de 30 a 39 años para ayudar a fortalecer sus capacidades condicionales en especial: la fuerza y la resistencia. Este programa se desarrolló en un periodo de tres meses, siendo un tipo de estudio cuantitativo, descriptivo y preexperimental, con una población de 20 mujeres entre 30 y 39 años de Ciudad del Carmen, Campeche a quienes se les realizó una prueba previa, el programa de intervención y se aplicó un post-test para la recolección y análisis de datos. Todo lo anterior bajo el consentimiento de los participantes.
Palabras clave:
Actividad física, fuerza, resistencia, sistema de ejercicios, mujeres y entrenamiento.

ABSTRACT
In the investigation, a physical conditioning program is developed through which the physical capacities are developed to improve the quality of life in women from 30 to 39 years of age to help strengthen their conditional capacities, especially: strength and resistance. This program will be developed in a period of three months, being a type of quantitative, descriptive and pre-experimental study, with a population of 20 women between 30 and 39 years of age from Ciudad del Carmen, Campeche who underwent a previous test, the program intervention and a post-test was applied for data collection and analysis. All of the above under the consent of the participants.
Keywords:
Physical activity, strength, endurance, exercise system, women and training.
Editorial
Authors: Pino Sera PhD. Yamilka 
Published: January 2023

Enero es el primer mes del año y con él se inicia un número más de la revista Excelencia Educativa (EXCED), encaminada a la sostenibilidad de la ciencia y fin de dar solución a las principales demandas académicas y científicas de los diferentes profesionales que nos asisten. La sociedad, y con ellas las diferentes instituciones que la integran potencian la ciencia de la sostenibilidad, mediante el empleo de nuevas técnicas, métodos científicos, la aplicación herramientas matemáticas, para con ello lograr satisfacer las necesidades sociales, materiales y espirituales.
Las ciencias sociales, como constructo humano, tienen una determinada sostenibilidad y finalidad, ofrecer soluciones a temáticas como las presentada en el presente número de la revista, tales como: “Efectos de las bacterias RR72, RR79 RC138 en el crecimiento de Cucumis sativus L en casa de cultivos protegidos”, o la incorporación de nuevas tecnologías como el: “Diseño del sistema automatizado para la generación y gestión de documentos en la etapa precontractual de compras públicas para instituciones públicas en el Ecuador” y la implementación de un “Programa de acondicionamiento físico para mejorar la fuerza en mujeres de 30 a 39 años en Ciudad del Carmen, México”.
En tal sentido, la revista enriquece la Ciencia de la Sostenibilidad, como una forma más de modificar las ciencias y la sociedad, por lo que les recomendamos leer “Las tecnologías de la información y la comunicación en la práctica docente con alumnos universitarios de nuevo ingreso durante COVID-19”, con una interesante novedad acerca del uso de la tecnología para la aprensión de determinados conceptos “El Proceso de enseñanza-aprendizaje de los conceptos de la matemática superior en las carreras de Ingeniería”; también sobre problemáticas que aquejan a determinados profesionales como el “Burnout, estrés y autoestima sobre el rendimiento académico en universitarios del área de la salud” y por último le sugerimos consultar el “Papel del abogado en la defensa del principio constitucional de presunción de inocencia en Cuba”. Esta interdisciplinariedad enriquece la publicación y comparte saberes científicos y culturales.
Faktor - Faktor yang Berhubungan dengan Kematian Pasien COVID-19 Lansia di Ruang Rawat Inap RSUD Kabupaten Karanganyar
Authors: Hidayati Soraya , Adnan Nurhayati 
Published: January 2023

Virus COVID-19 terus menyebabkan lebih banyak orang menjadi sakit dan meninggal dunia setiap harinya. Selain itu, varian virus COVID-19 baru juga terus ditemukan. Lebih dari 80% kematian karena COVID-19 terjadi pada penderita yang memiliki komorbid dan berusia di atas 65 tahun. Perlu diketahui penyakit komorbid apa saja yang berpengaruh terhadap kematian pasien COVID-19 lansia. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang dapat meningkatkan risiko kematian COVID-19 pada pasien lansia yang melakukan rawat inap di RSUD Karanganyar mulai Januari 2020 - Mei 2021. Sebanyak 322 pasien COVID-19 lansia yang terdata dalam file database rekam medis pasien rawat inap di RSUD Kabupaten Karanganyar digunakan dalam penelitian kuantitatif ini dengan menggunakan desain cross sectional. Analisis data dilakukan dengan menggunakan regresi logistik untuk menguji hubungan jenis kelamin, TBC paru, diabetes mellitus, ginjal kronis, stroke, dan jantung dengan kematian pasien COVID-19 lansia. Dari total sampel yang diteliti, sebanyak 18,9% diantaranya meninggal dunia. Pasien COVID-19 lansia perempuan yang meninggal dunia adalah sebanyak 54,1%. Dari total 61 pasien COVID-19 lansia yang meninggal, penyakit komorbid yang paling banyak diderita adalah DM (21,3%), hipertensi (16,4%), stroke (11,5%), ginjal kronis (8,2%), jantung (8,2%), dan TBC paru (3,3%). Hasil analisis multivariat menunjukkan bahwa hanya riwayat hipertensi yang secara statistik terkait dengan peningkatan risiko kematian pada pasien COVID-19 lansia (OR= 2,647; 95% CI: 1,154 – 6,070), sedangkan variabel yang lainnya tidak berhubungan. Pasien lansia dengan komorbid tersebut perlu diprioritaskan untuk diberikan penanganan medis secara optimal karena lebih rentan terhadap kematian.
Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution
Authors: Ainciburu Marina , Ezponda Teresa , Berastegui Nerea , Alfonso-Pierola Ana , Vilas-Zornoza Amaia , San Martin-Uriz Patxi , Alignani Diego , Lamo-Espinosa Jose , San-Julian Mikel , Jiménez-Solas Tamara , Lopez Felix , Muntion Sandra , Sanchez-Guijo Fermin , Molero Antonieta , Montoro Julia , Serrano Guillermo , Diaz-Mazkiaran Aintzane , Lasaga Miren , Gomez-Cabrero David , Diez-Campelo Maria , Valcarcel David , Hernaez Mikel , Romero Juan P , Prosper Felipe 
Published: January 2023

Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regulation of HSPCs. In this study, we used single-cell RNA sequencing (scRNA-seq) to characterize an enriched population of human HSPCs obtained from young and elderly healthy individuals.Based on their transcriptional profile, we identified changes in the proportions of progenitor compartments during aging, and differences in their functionality, as evidenced by gene set enrichment analysis. Trajectory inference revealed that altered gene expression dynamics accompanied cell differentiation, which could explain aging-associated changes in hematopoiesis. Next, we focused on key regulators of transcription by constructing gene regulatory networks (GRNs) and detected regulons that were specifically active in elderly individuals. Using previous findings in healthy cells as a reference, we analyzed scRNA-seq data obtained from patients with myelodysplastic syndrome (MDS) and detected specific alterations of the expression dynamics of genes involved in erythroid differentiation in all patients with MDS such as TRIB2. In addition, the comparison between transcriptional programs and GRNs regulating normal HSPCs and MDS HSPCs allowed identification of regulons that were specifically active in MDS cases such as SMAD1, HOXA6, POU2F2, and RUNX1 suggesting a role of these transcription factors (TFs) in the pathogenesis of the disease.In summary, we demonstrate that the combination of single-cell technologies with computational analysis tools enable the study of a variety of cellular mechanisms involved in complex biological systems such as early hematopoiesis and can be used to dissect perturbed differentiation trajectories associated with perturbations such as aging and malignant transformation. Furthermore, the identification of abnormal regulatory mechanisms associated with myeloid malignancies could be exploited for personalized therapeutic approaches in individual patients.
Boswellia serrata Roxb. Ex Coleb.: A Threatened Tree
Authors: Warrier Kannan C. S. , Muthupandiyan S. 
Published: January 2023

Boswellia serrata Roxb. ex Coleb. is commonly known as Indian Olibanum or Indian Frankincense tree. It belongs to the family Burseraceae. The tree is confined to Tropical Dry Deciduous Forest of India. It grows at altitudes up to 1,150 m in regions with annual temperatures between 0-45°C and annual rainfall between 500-2,000 mm. B. serrata has been listed in the threatened species of India. The principal threats of this species are slow growth coupled with poor regeneration. However, the population trends and habitat trends are stable. Due to its exudations of volatile oil, resin and gum, the tree has attained commercial significance. The oil obtained from this tree is very similar to turpentine oil and found suitable for paint making, varnish and used as printing ink in textile industries and in making distempers. It is a unique non coniferous source of turpentine employed for the manufacture of paints and varnishes. The resin obtained from this tree is used for preparation of varnishes. The tree exudes of B. serrata resembles Canada balsam in colour and consistency. It is mainly used for medicinal purposes and incense. A detailed review covering its taxonomy and nomenclature, distribution in India, reproductive biology, wood properties, processing and harvesting, genetic resources available, reasons for its deterioration, and its uses is presented in this article.
Dorsal approach for advanced gastric cancer invading the transverse mesocolon
Authors: Okabe Hiroshi , Aoyama Hiroki , Miyahara Yoji , Sunagawa Hideki 
Published: January 2023

AbstractMinimally invasive gastrectomy is increasingly performed for advanced gastric cancer, but the indication for this procedure for a tumor invading adjacent structures is still limited. In cases with tumors invading the transverse mesocolon, a large tumor together with the involved mesocolon blocks the surgical view, which prevents evaluation of the extent of invasion and makes it difficult to ensure oncologically adequate resection. To solve these technical issues, we established a novel method that uses a dorsal approach. By approaching the transverse mesocolon from the dorsal side, tumor penetration and involvement of the colic vessels or pancreas can be evaluated, and margin‐free resection of the tumor becomes easier. In a series of 13 patients with mesocolon invasion, a dorsal approach enabled minimally invasive margin‐free resection in 11 cases by resection of the anterior layer of the mesocolon (n = 6); enucleation of the mesocolon (n = 4); or enucleation plus distal pancreato‐splenectomy (n = 1). Two patients with broad invasion that obstructed the view underwent combined colectomy by open conversion. A major postoperative complication of pancreatic fistula following distal pancreatectomy occurred in one case. These results suggest that a dorsal approach may be useful for minimally invasive combined resection of gastric cancer invading the transverse mesocolon.
Dynamic gas‐diffusion electrodes for oxygen electroreduction to hydrogen peroxide
Authors: Xia Baokai , Huang Qi , Wu Kaijie , Jiang Lili , Li Ming , Yu Licheng , Ding Shan , Nie Zhihao , Hua Dingyang , Duan Jingjing , Chen Sheng 
Published: January 2023

AbstractFlow‐type electrolytic cell is a viable system for many electrochemical processes, in which gas‐diffusion electrode (GDE) plays a vital role in providing optimal reacting interfaces for improved performances. Different from traditional GDEs with fixed porosity, here we propose a new type of GDE that features flexible diffusion channels. Particularly, the GDE has been assembled by pairing PTFE substrate with Ag‐TCNQ/graphene hydrogels that can be further manipulated through capillary compression. With dynamic adjustment, the average pore size inside GDE ranges from 1750 to 125 nm, and the packing density varies from 56.81 to 446.07 mg cm−3. As a consequence, the as‐assembled flow‐type electrolytic cell can display excellent performances, with a yield rate of 5572 mmol gcat−1 h−1 and Faradic efficiency of 86.4% at 0.267 V (vs. RHE). In addition, a photovoltaic (PV)‐driven flow‐electrolytic system has been assembled that achieves a record solar‐to‐hydrogen peroxide efficiency of 14.8%.
Amide group enhanced self‐assembly and adsorption of thioether‐containing hydroxamic acid on cassiterite surface
Authors: Sun Qing , Dong Yan , Wang Shuai , Cao Zhanfang , Ma Xin , Zhong Hong 
Published: January 2023

AbstractModified surfactants can regulate their adsorption at the target surface and are essential for various separation applications such as froth flotation. Thioether‐containing hydroxamic acid (BTHA) is an excellent oxidized‐ore collector with poor dispersibility. Herein, acylamino, which possesses the ability to improve the surfactants' self‐assembly and dispersion, was introduced to synthesize N‐[6‐(hydroxyamino)‐6‐oxohexyl] benzylthioacetamide (BTAHA); thus, applying it to cassiterite flotation. Surface tension, adsorption capacity, in situ AFM, and surface energy results reveal BTAHA displays strong bubble stability and readily adsorbs onto the mineral's surface, promoting hydrophobic flotation. BTAHA is an effective cassiterite collector and has good separation effects on cassiterite against calcite. It can form Van der Waals forces and five‐membered hydroxamate‐(O,O)‐Sn rings with Sn atoms on cassiterite surfaces via thioether and hydroxamate groups. Meanwhile, the presence of intermolecular hydrogen bond between the amide groups facilitates the self‐assembly of the collectors on the cassiterite surface, and has broad industrial application prospects in various separation processes.
Disease Activity and Health‐Related Quality of Life Among Patients With Rheumatoid Arthritis With Different Alcohol Consumption Habits
Authors: Alfredsson Lars , Klareskog Lars , Hedström Anna Karin 
Published: January 2023

ObjectiveMultiple studies have found a relationship between alcohol consumption and disease activity in rheumatoid arthritis (RA), although reverse causation has been suggested to explain the association. We aimed to study the relationship between alcohol consumption and disease activity, disease progression, and health‐related quality of life in patients with RA.MethodsWe followed up 1,228 patients with newly diagnosed RA from a population‐based case–control study, Epidemiological Investigation of Rheumatoid Arthritis (EIRA). Drinkers and non‐drinkers were compared to evaluate risk of unfavorable outcomes regarding disease activity and health‐related quality of life. Odds ratios with 95% confidence intervals were calculated using logistic regression models.ResultsNon‐drinkers at baseline had higher disease activity and estimated their pain as more severe compared to drinkers. At 1 year of follow‐up, non‐drinkers reported higher swollen and tender joint counts and experienced more pain and fatigue, lower global health scores, and lower health‐related quality of life. The inverse relationship between alcohol consumption and RA‐specific outcomes was also observed when comparing drinkers and non‐drinkers who had not changed their alcohol consumption habits at or after the year of disease onset. Those who stopped drinking postbaseline experienced higher disease activity, more pain, and lower health‐related quality of life at 1 year of follow‐up, compared to drinkers, although there was no difference in disease activity at baseline between drinkers who continued versus discontinued drinking. Our findings argue against bias due to reverse causation.ConclusionAlcohol consumption was associated with lower disease activity and higher health‐related quality of life in RA patients in a dose‐dependent manner.