bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitigation of paclitaxel-induced peripheral neuropathy in breast cancer patients using limb-cooling apparatus: a study protocol for a randomized controlled trial
Authors: Funasaka Chikako , Hanai Akiko , Zenda Sadamoto , Mori Keita , Fukui Makoto , Hirano Nami , Shinohara Rie , Fuse Nozomu , Wakabayashi Masashi , Itagaki Mai , Tomioka Yutaka , Nishina Michihiko , Arai Yasuaki , Kogawa Takahiro , Ozaki Yukinori , Nishimura Meiko , Kobayashi Takayuki , Hara Fumikata , Takano Toshimi , Mukohara Toru 
Published: July 2023

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) is one of the most common adverse events that can significantly impair the quality of life of patients. Although limb cooling may be beneficial for preventing CIPN, logistical challenges exist in ensuring consistent efficacy and safety. The purpose of this randomized controlled trial is to validate whether limb cooling with strict temperature control can reduce CIPN in patients with breast cancer receiving weekly paclitaxel as a perioperative treatment.MethodsThis study is a multicenter, double-blinded, randomized controlled trial. We plan to enroll patients with breast cancer who are scheduled to receive 12 weekly doses of paclitaxel (60 min 80 mg/m2 intravenous infusion) as perioperative chemotherapy. Patients will be randomly divided into the intervention or control groups and undergo limb cooling therapy maintained at a constant temperature of 13°C and 25°C, respectively. The primary endpoint is the proportion of patients who report Patient Neurotoxicity Questionnaire (PNQ) ≥ D in their limbs by the end of the study treatment or at the time of discontinuation.DiscussionThe results of this trial will contribute to the establishment of new evidence for limb cooling therapy in the mitigation of CIPN and present a safe and stable cooling device that may be suitable for use in the clinic.Clinical trial registrationhttps://jrct.niph.go.jp/en-latest-detail/jRCT2032210115, identifier jRCT2032210115.
Maternal time investment in caregiving activities to promote early childhood development: evidence from rural India
Authors: Batura Neha , Roy Reetabrata , Aziz Sarmad , Sharma Kamalkant , Kumar Divya , Verma Deepali , Correa Ossa Ana , Spinola Paula , Soremekun Seyi , Sikander Siham , Zafar Shamsa , Divan Gauri , Hill Zelee , Avan Bilal Iqbal , Rahman Atif , Kirkwood Betty , Skordis Jolene 
Published: July 2023

IntroductionIntervention strategies that seek to improve early childhood development outcomes are often targeted at the primary caregivers of children, usually mothers. The interventions require mothers to assimilate new information and then act upon it by allocating sufficient physical resources and time to adopt and perform development promoting behaviours. However, women face many competing demands on their resources and time, returning to familiar habits and behaviours. In this study, we explore mothers' allocation of time for caregiving activities for children under the age of 2, nested within a cluster randomised controlled trial of a nutrition and care for development intervention in rural Haryana, India.MethodsWe collected quantitative maternal time use data at two time points in rural Haryana, India, using a bespoke survey instrument. Data were collected from 704 mothers when their child was 12 months old, and 603 mothers when their child was 18 months old. We tested for significant differences in time spent by mothers on different activities when children are 12 months of age vs. 18 months of age between arms as well as over time, using linear regression. As these data were collected within a randomised controlled trial, we adjusted for clusters using random effects when testing for significant differences between the two time points.ResultsAt both time points, no statistically significant difference in maternal time use was found between arms. On average, mothers spent most of their waking time on household chores (over 6 h and 30 min) at both time points. When children were aged 12 months, approximately three and a half hours were spent on childcare activities for children under the age of 2 years. When children were 18 months old, mothers spent more time on income generating activities (30 min) than when the children were 12 years old, and on leisure (approximately 4 h and 30 min). When children were 18 months old, less time was spent on feeding/breastfeeding children (30 min less) and playing with children (15 min). However, mothers spent more time talking or reading to children at 18 months than at 12 months.ConclusionWe find that within a relatively short period of time in early childhood, maternal (or caregiver) time use can change, with time allocation being diverted away from childcare activities to others. This suggests that changing maternal time allocation in resource poor households may be quite challenging, and not allow the uptake of new and/or optimal behaviours.
Higher NICU admissions in infants born at ≥35 weeks gestational age during the COVID-19 pandemic
Authors: Jegatheesan Priya , Narasimhan Sudha Rani , Huang Angela , Nudelman Matthew , Song Dongli 
Published: July 2023

BackgroundIncreasing evidence has shown that the COVID-19 pandemic has had a profound negative impact on vulnerable populations and a significant effect on maternal and neonatal health. We observed an increase in the percentage of infants admitted to NICU from 8% to 10% in the first year of the pandemic. This study aimed to compare the delivery room outcomes, NICU admissions and interventions, and neonatal outcomes two years before and during the pandemic.MethodsThis was a retrospective study in a public hospital between pre-COVID-19 (April 2018–December 2019) and COVID-19 (April 2020–December 2021). Data were obtained from all live births at ≥35 weeks gestation (GA). Maternal and neonatal demographics, delivery room (DR), and NICU neonatal outcomes were compared between the study periods using simple bivariable generalized estimating equations (GEE) regression. Multivariable GEE logistic regression analysis was performed to adjust for the effects of baseline differences in demographics on the outcomes.ResultsA total of 9,632 infants were born ≥35 weeks gestation during the study period (pre-COVID-19 n = 4,967, COVID-19 n = 4,665). During the COVID-19 period, there was a small but significant decrease in birth weight (33 g); increases in maternal diabetes (3.3%), hypertension (4.1%), and Hispanic ethnicity (4.7%). There was a decrease in infants who received three minutes (78.1% vs. 70.3%, p &lt; 0.001) of delayed cord clamping and increases in the exclusive breastfeeding rate (65.9% vs. 70.1%, p &lt; 0.001), metabolic acidosis (0.7% vs. 1.2%, p = 0.02), NICU admission (5.1% vs. 6.4%, p = 0.009), antibiotic (0.7% vs. 1.7%, p &lt; 0.001), and nasal CPAP (1.2% vs. 1.8%, p = 0.02) use. NICU admissions and nasal CPAP were not significantly increased after adjusting for GA, maternal diabetes, and hypertension; however, other differences remained significant. Maternal hypertension was an independent risk factor for all these outcomes.ConclusionDuring the COVID-19 pandemic period, we observed a significant increase in maternal morbidities, exclusive breastfeeding, and NICU admissions in infants born at ≥35 weeks gestation. The increase in NICU admission during the COVID-19 pandemic was explained by maternal hypertension, but other adverse neonatal outcomes were only partly explained by maternal hypertension. Socio-economic factors and other social determinants of health need to be further explored to understand the full impact on neonatal outcomes.
Clinical pharmacy services for tuberculosis management: a systematic review
Authors: Iskandar D. , Suryanegara F. D. A. , van Boven J. F. M. , Postma M. J. 
Published: July 2023

Objective: This study aims to systematically review the content and potential effects of clinical pharmacy services in tuberculosis (TB) care management.Methods: Searches were performed in PubMed, Embase, Cochrane, Scopus, and Web of Science databases following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Study characteristics and outcomes were extracted, and clinical pharmacy service components were characterized using the Descriptive Elements of Pharmacist Intervention Characterization Tool.Results: Twenty articles were included for full-text assessment, of which 10 fulfilled inclusion criteria, comprising 1,168 patients (N = 39 to 258 per study). These articles included five prospective cohort studies, two case–control studies, two quasi-experimental studies, and one cross-sectional study. Intervention foci within clinical pharmacy services were medication adherence (50%), medication safety (40%), education to patients/caregivers regarding needs/beliefs (30%), optimizing medication/therapy effectiveness (30%), emphasizing HRQoL (10%), and drug selections (10%). The three most frequently applied interventions were drug information/patient counseling (80%), adverse drug reaction monitoring (50%), and drug use evaluation (20%). Based on the World Health Organization (WHO) outcome classification, treatment success ranged from 72% to 93%, with higher cure outcomes (53%–86%) than treatment completion (7%–19%). Other outcomes, including isoniazid metabolites, medication counts, sputum conversion, adherence/compliance, knowledge, and quality of life, were better in the intervention group than those in comparator groups, and/or they improved over time. Risk of bias analysis indicated that the included studies were not comparable to a randomized clinical trial.Conclusion: Clinical pharmacy services as single or composite interventions potentially improve TB outcomes, but its evidence is still inconsistent and limited due to the lack of randomized controlled studies using the WHO outcome classification.Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=199028, identifier CRD42020199028.
Absorption, tissue distribution, and excretion of glycycoumarin, a major bioactive coumarin from Chinese licorice (Glycyrrhiza uralensis Fisch)
Authors: Ye Linhu , Cheng Lei , Deng Yan , Wang Sen , Wu Xinyu , Ou Shuiping , Chang Qi , Zhao Xinqian , Zhou Wen , Yu Jinghua , Wu Zuqiang 
Published: July 2023

Licorice (Glycyrrhiza uralensis Fisch) is a natural plant resource widely used as a food and herbal medication in China. Glycycoumarin (GCM) is a major coumarin in licorice that possesses several biological activities. However, little is known about its pharmacokinetic profile. The present study aimed to describe the oral absorption, tissue distribution, and excretion of GCM in rats. Free (parent drug) and/or total (parent drug plus the glucuronidated metabolite) GCM in biological samples was quantified before and after the hydrolysis reaction with β-glucuronidase using a reliable LC-MS/MS method. The results indicated that GCM was rapidly absorbed and transformed into its conjugated metabolites after administration. Free GCM plasma concentrations after i. v. (10 mg/kg) administration quickly decreased with an average t1/2,λz of 0.71 h, whereas the total GCM concentration reduced slowly with a t1/2, λz of 2.46 h. The area under the curve of glucuronidated metabolites was approximately four-times higher than that of free GCM. Presumably, because of hepatic and/or intestinal tract first-pass metabolism, GCM exhibited a poor bioavailability of 9.22%, as estimated from its total plasma concentration. Additionally, GCM was distributed rapidly and widely in various tissues except the brain. The liver had the highest concentration; further, GCM was promptly eliminated from test tissues after intraperitoneal (20 mg/kg) administration, but only a small amount of GCM was excreted via bile and urine. Overall, GCM is absorbed and rapidly transformed into its conjugated metabolites with low bioavailability; further, it is distributed in various tissues, except the brain. These pharmacokinetic results are helpful for better understanding the characteristics and pharmacological effects of GCM.
Subcellular positioning during cell division and cell plate formation in maize
Authors: Allsman Lindy A. , Bellinger Marschal A. , Huang Vivian , Duong Matthew , Contreras Alondra , Romero Andrea N. , Verboonen Benjamin , Sidhu Sukhmani , Zhang Xiaoguo , Steinkraus Holly , Uyehara Aimee N. , Martinez Stephanie E. , Sinclair Rosalie M. , Soriano Gabriela Salazar , Diep Beatrice , Byrd V. Dawson , Noriega Alexander , Drakakaki Georgia , Sylvester Anne W. , Rasmussen Carolyn G. 
Published: July 2023

IntroductionDuring proliferative plant cell division, the new cell wall, called the cell plate, is first built in the middle of the cell and then expands outward to complete cytokinesis. This dynamic process requires coordinated movement and arrangement of the cytoskeleton and organelles.MethodsHere we use live-cell markers to track the dynamic reorganization of microtubules, nuclei, endoplasmic reticulum, and endomembrane compartments during division and the formation of the cell plate in maize leaf epidermal cells.ResultsThe microtubule plus-end localized protein END BINDING1 (EB1) highlighted increasing microtubule dynamicity during mitosis to support rapid changes in microtubule structures. The localization of the cell-plate specific syntaxin KNOLLE, several RAB-GTPases, as well as two plasma membrane localized proteins was assessed after treatment with the cytokinesis-specific callose-deposition inhibitor Endosidin7 (ES7) and the microtubule-disrupting herbicide chlorpropham (CIPC). While ES7 caused cell plate defects in Arabidopsis thaliana, it did not alter callose accumulation, or disrupt cell plate formation in maize. In contrast, CIPC treatment of maize epidermal cells occasionally produced irregular cell plates that split or fragmented, but did not otherwise disrupt the accumulation of cell-plate localized proteins.DiscussionTogether, these markers provide a robust suite of tools to examine subcellular trafficking and organellar organization during mitosis and cell plate formation in maize.
Pain-related and psychological factors mediate the effect of personality on health-related quality of life. A study in breast cancer survivors with persistent pain
Authors: Aho Tommi , Harno Hanna , Lipsanen Jari , Kalso Eija , Sipilä Reetta 
Published: July 2023

IntroductionPersonality characteristics affect the long-term well-being and health-related quality of life (HrQoL) of breast cancer (BC) survivors. Persistent pain significantly affects psychosocial well-being and HrQoL in this patient group. We studied the effects of temperament and character via pain-related and psychological factors on dimensions of HrQoL in BC survivors.MethodsWe studied 273 patients who had been treated for BC and who reported persistent pain at any site of the body in Brief Pain Inventory. The patients were recruited from a longitudinal cohort of patients 4–9 years after surgery for BC. Short-Form-36 inventory was used to assess physical and mental dimensions of HrQoL and Temperament and Character Inventory to assess dimensions of temperament and character. We used parallel mediation modeling for studying effects of temperament and character on physical and mental HrQoL.ResultsA significant total effect was found for harm avoidance (HA) temperament (βtotal = −0.665, p &lt; 0.001) and character dimensions self-directedness (SD) (βtotal = 0.609, p = 0.001) and cooperativeness (CO) (βtotal = 0.584, p = 0.028) on physical and mental HrQoL. Additionally, different combinations of pain-related and psychological variables fully mediated the indirect effects of HA, SD, and CO on physical and mental HrQoL.DiscussionHA temperament is a potential emotional vulnerability factor for psychological burden and impaired HrQoL in BC survivors. Character dimensions SD and CO may protect from the negative effect of mood on HrQoL. The results provide new insights about the risk-and target-factors for clinical interventions and effective pain management to improve psychosocial well-being and HrQoL in BC survivors.
Perceptions of the double value coupon program in southern Illinois
Authors: Rose Dominique M. , Donahoo Saran , McDaniel Justin T. , Null Dawn , McLernon Michelle , Kruse-Diehr Aaron J. 
Published: July 2023

IntroductionPurchasing produce at farmers markets represents one method by which individuals can purchase and have access to healthful and seasonal fruits. Despite the extension of nutrition assistance programs to local farmers markets, fruit and vegetables consumption has remained below the recommended guidelines, specifically in rural geographical locations.Statement of purposeThe purpose of the study was to explore the aspects of the Link Up Illinois Double Value SNAP Nutrition Incentives Program (DVCP) and its effects on food selection at rural farmers markets for individuals enrolled in nutrition assistance programs.Methods/approachThe current study uses a qualitative methodology in order to uncover barriers local health departments and farmers markets face to implementing the DVCP in their communities and to discover the perspectives of low-income individuals who utilize the DVCP. This paper explores the organizational and community member perceptions of the DVCP and its administration. Semi-structured interviews and one focus group were conducted with health educators from county health departments, DVCP stakeholders, farmers market managers, local farmers, and residents who used the DVCP. A purposeful sampling method was used, intentionally selecting individuals with lived experiences of the research objective. Data were analyzed using a three-cycle coding process, then categorized into overarching themes until thematic saturation was reached.ResultsThere were a total of 19 individuals who participated in the study. Five themes and four subthemes emerged from data analysis, including organizational capacity, exposure to the DVCP, purchasing power, DVCP advancements, and values.Conclusion/implicationsThese findings contextualize the facilitators and barriers of multiple stakeholders when implementing nutrition assistance programs at farmers markets. Other similar “double value” programs can utilize these lessons when seeking to increase participation of underrepresented populations at local farmers markets.
How and why pharmaceutical reforms contribute to universal health coverage through improving equitable access to medicines: a case of Ghana
Authors: Koduah Augustina 
Published: July 2023

BackgroundExamining how and why a country prioritizes and implements pharmaceutical reforms tends to show complex processes and myriad efforts made toward improving access to medicines. This study examines factors that enabled the prioritization and implementation of selected pharmaceutical reform items and how these factors contributed to improving equitable access to medicines and universal health coverage in Ghana.MethodsAn analytical framework was developed to identify variables to explore in answering the study questions and frame the analysis and presentation of findings. Documents analyzed included the National Medicines Policies, Health Sector Program of Work, and other health policies. Quantitative data were sourced from databases maintained by World Health Organization and the Institute for Health Metrics and Evaluation.ResultsThe three main factors, evidence, financial and technical support, and alignment to national and global policies, influenced the prioritization and implementation of access to medicines reforms. The reforms targeted rational selection and use of medicines, medicine pricing, sustainable medicine financing, and regulatory and supply chain systems. Although there were limited quantitative data to quantify access to medicine policies” impact on universal health coverage, it can be reasonably assumed that, in Ghana, access to medicine policies has contributed to financial protection and improved access to quality health services.ConclusionAccess to medicine policies targeted at promoting rational medicine selection and use, regulating medicine pricing and improving sustainable financing for medicines as well as the regulatory and supply chain systems arguably contributed to the attainment of UHC and must be sustained. Therefore, data collection and reporting indicators for access to medicines must be prioritized.
ASSOCIAÇÃO DA OZONIOTERAPIA COM INTRACONAZOL PARA TRATAMENTO DAS LESÕES DE ESPOROTRICOSE FELINA: RELATO DE CASO.
Authors: Sampaio Calheiros André , De Moraes Calheiros Luís Gustavo , Moreira dos Santos Carnaúba Rayane Thayse , Medeiros Caldas Júnior Neusvaldo , Cecílio de Souza Filho Nilton , Domingos Sales Lima Álvaro 
Published: July 2023

A esporotricose é uma micose de difícil tratamento e tem os gatos como um dos principais hospedeiros. Suas manifestações clínicas são caracterizadas, principalmente por lesões de continuidade ulcerativas na pele e subcutâneo, linfocutânea, disseminada, com presença de sinais extracutâneo e sistêmica fatal. Seu tratamento baseia-se na administração de antifúngicos sistêmicos e tópicos, porém causam danos expressivos ao organismo e ao ambiemte. Com poucas opções de tratamento, a ozonioterapia pode ser indicada para o tratamento de afecções infecciosas para esporotricose, devido a ação fungicida, analgésica e anti-inflamatória. Objetivou-se em descrever o caso clínico de um felino, macho, castrado de 1 ano e 8 meses, que apresentava lesões ulcerativas no membro pélvico esquerdo e coxim plantar, diagnosticado com esporotricose. Uma vez que não havia a regressão das lesões com o tratamento convencional, foi instituído a ozonioterapia pela técnica de insuflação de bag’s. Após 12 sessões, as feridas estavam parcialmente cicatrizadas, manteve-se o tratamento convencional com a adição do uso de óleo de girassol ozonizado até a regressão total das lesões.
Tecnologias digitais da informação e comunicação: produção e implementação de materiais didáticos em escolas da rede pública do estado do Rio Grande do Sul
Authors: Dos Santos Guidotti Charles , Arrieche Fazio Anahy , Pires Ruas Franciele , Mumbach Simone 
Published: July 2023

O artigo apresenta parte do estudo que objetivou diagnosticar as condições de acesso, produção, implementação e avaliação de atividades pedagógicas no contexto online de professores de Matemática, Física, Química, Biologia e Ciências atuantes em escolas localizadas no estado do Rio Grande do Sul. O diagnóstico não se restringiu ao período pandêmico, apesar de compreendermos que durante esse período, recursos digitais foram implementados com maior intensidade. Neste artigo focamos na apresentação e análise das informações referentes aos desafios da produção e implementação de materiais didáticos com o uso das tecnologias digitais. A coleta de informações foi realizada através de um formulário virtual, constituído de 27 questões, sendo que participaram da pesquisa 29 professores. A análise dos resultados revelou que o período pandêmico oportunizou o aperfeiçoamento de práticas pedagógicas dos professores a partir e com as tecnologias digitais. Além disso, as respostas sinalizaram que os professores se mostram receptivos à utilização desses recursos no (re)criar desenhos didáticos, mesmo em período pós-pandemia, com vistas à superação da fragmentação e da reprodução linearizada de conhecimentos. Porém, ainda indicam a necessidade de melhorias na infraestrutura tecnológica das escolas e da criação de espaços formativos que alinhem a formação técnica e pedagógica.
Palavras-chave: Tecnologias digitais de informação e comunicação. Diagnóstico. Educação em Ciências e Matemática.