bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel, Uniquely Efficacious Type of CFTR Corrector with Complementary Mode of Action
Authors: Marchesin Valentina , Monnier Lucile , Blattmann Peter , Chevillard Florent , Kuntz Christine , Forny Camille , Kamper Judith , Studer Rolf , Bossu Alexandre , Ertel Eric A. , Nayler Oliver , Brotschi Christine , Williams Jodi T. , Gatfield John 
Published: August 2023

ABSTRACTThree distinct pharmacological corrector types (I, II, III) with different binding sites and additive behaviour only partially rescue the F508del-CFTR folding and trafficking defect observed in cystic fibrosis. Here, we describe novel, uniquely effective, macrocyclic CFTR correctors that were additive to the known corrector types, thus exerting a new, complementary “type-IV” corrector mechanism. Macrocycles achieved wildtype-like folding efficiency of F508del-CFTR at the endoplasmic reticulum and normalized CFTR currents in reconstituted patient-derived bronchial epithelium. Using photo-activatable macrocycles, docking studies and site-directed mutagenesis a highly probable binding site and pose for type-IV correctors was identified in a cavity between lasso helix-1 (Lh1) and transmembrane helix-1 of membrane spanning domain-1 (MSD1), distinct from the known corrector binding sites. Since only F508del-CFTR fragments spanning from Lh1 until MSD2 responded to type-IV correctors, these likely promote co-translational assembly of Lh1, MSD1, and MSD2. Remarkably, previously corrector-resistant CFTR folding mutations were also robustly rescued, suggesting substantial therapeutic potential for this novel type-IV corrector mechanism.TeaserA novel type of macrocyclic CFTR corrector with new binding site, complementary mode of action and unique folding / trafficking efficacy is described.
Post-occupancy evaluation of residential properties: a case study on an organizational multistorey apartment building
Authors: Hassanain Mohammad A. , Al-Suwaiti Ibrahim , Ibrahim Ahmed M. 
Published: August 2023

PurposeThis paper aims to provide an exemplary application of an indicative post-occupancy evaluation (POE) on an organizational multistorey residential apartment building.Design/methodology/approachThis research comprises of mixed qualitative and quantitative approaches. The methodology commences with a review of the recent literature, identification of performance elements, conduct of walk-through, distribution and collection of users' surveys and the development of short and long-term recommendations, where an adequate sample of users were approached for conducting a focus group interview session.FindingsThe research identifies 74 performance elements that were clustered into technical, namely (thermal, acoustic and visual comforts, indoor air quality and safety and security), functional, namely (design adequacy, finishing, furnishing, fittings and equipment and building surroundings) dimensions and behavioral, namely (apartment building attributes and managerial and logistical support). The questionnaire survey aimed to solicit users' opinions upon the occupied case study residential facility.Originality/valueThe research identifies areas of occupants' satisfaction and dissatisfaction in a typical multistorey residential building, as a part of a community housings for a mega organization, located in Saudi Arabia. The identification of these areas serves as a lesson learned for future developments, design considerations and implications. Hence, improving the well-being and comfort of its employees.
Methods for calculating aerodynamics inside high-speed railway tunnel lining cracks and predicating stress intensity factors
Authors: Liu Yi-Kang , Liu Xin-Yuan , Deng E. , Ni Yi-Qing , Yue Huan 
Published: August 2023

Purpose
This study aims to propose a series of numerical and surrogate models to investigate the aerodynamic pressure inside cracks in high-speed railway tunnel linings and to predict the stress intensity factors (SIFs) at the crack tip.

Design/methodology/approach
A computational fluid dynamics (CFD) model is used to calculate the aerodynamic pressure exerted on two cracked surfaces. The simulation uses the viscous unsteady κ-ε turbulence model. Using this CFD model, the spatial and temporal distribution of aerodynamic pressure inside longitudinal, oblique and circumferential cracks are analyzed. The mechanism behind the pressure variation in tunnel lining cracks is revealed by the air density field. Furthermore, a response surface model (RSM) is proposed to predict the maximum SIF at the crack tip of circumferential cracks and analyze its influential parameters.

Findings
The initial compression wave amplifies and oscillates in cracks in tunnel linings, resulting from an increase in air density at the crack front. The maximum pressure in the circumferential crack is 2.27 and 1.76 times higher than that in the longitudinal and oblique cracks, respectively. The RSM accurately predicts the SIF at the crack tip of circumferential cracks. The SIF at the crack tip is most affected by variations in train velocities, followed by the depth and length of the cracks.

Originality/value
The mechanism behind the variation of aerodynamic pressure in tunnel lining cracks is revealed. In addition, a reliable surrogate model is proposed to predict the mechanical response of the crack tip under aerodynamic pressures.
Riding a bicycle while building its wheels: the process of machine learning-based capability development and IT-business alignment practices
Authors: Mucha Tomasz , Ma Sijia , Abhari Kaveh 
Published: August 2023

PurposeRecent advancements in Artificial Intelligence (AI) and, at its core, Machine Learning (ML) offer opportunities for organizations to develop new or enhance existing capabilities. Despite the endless possibilities, organizations face operational challenges in harvesting the value of ML-based capabilities (MLbC), and current research has yet to explicate these challenges and theorize their remedies. To bridge the gap, this study explored the current practices to propose a systematic way of orchestrating MLbC development, which is an extension of ongoing digitalization of organizations.Design/methodology/approachData were collected from Finland's Artificial Intelligence Accelerator (FAIA) and complemented by follow-up interviews with experts outside FAIA in Europe, China and the United States over four years. Data were analyzed through open coding, thematic analysis and cross-comparison to develop a comprehensive understanding of the MLbC development process.FindingsThe analysis identified the main components of MLbC development, its three phases (development, release and operation) and two major MLbC development challenges: Temporal Complexity and Context Sensitivity. The study then introduced Fostering Temporal Congruence and Cultivating Organizational Meta-learning as strategic practices addressing these challenges.Originality/valueThis study offers a better theoretical explanation for the MLbC development process beyond MLOps (Machine Learning Operations) and its hindrances. It also proposes a practical way to align ML-based applications with business needs while accounting for their structural limitations. Beyond the MLbC context, this study offers a strategic framework that can be adapted for different cases of digital transformation that include automation and augmentation of work.
Rooting for the green: consumers and brand love
Authors: Hamouda Manel , Aissaoui Aroua 
Published: August 2023

Purpose
This study aims to investigate the nature of relationships between consumers and green brands and notably their role in shaping green brand evangelism. More particularly, the study first focuses on the influence of green relational benefits (confidence, self-expression, socialisation and altruistism) on green brand loyalty and subsequently the direct effect of green brand loyalty on green brand evangelism.

Design/methodology/approach
Data were collected using an online survey administered to a sample of 101 graduated female consumers of green personal care and beauty brands. Partial least square structural equation modelling was used to test the hypothesized relationships of the proposed conceptual model.

Findings
The study results demonstrate the existence of a positive and direct impact of confidence, socialization and self-expression benefits on green brand loyalty, with a stronger influence of confidence compared to the other benefits. Green brand loyalty generates a positive green brand evangelism from consumers.

Practical implications
To promote green brand evangelism, managers should invest in actions that enhance consumer loyalty towards green brands through a combination of confidence, socialization and self-expression benefits.

Originality/value
Although previous studies have discussed how relational benefits contribute to the development of brand loyalty, the issue has not been examined from a green brand perspective. In addition, this paper explores the antecedents of green brand evangelism, which have not been sufficiently addressed in the existing literature.
Manual assembly actions segmentation system using temporal-spatial-contact features
Authors: Kang Zengxin , Cui Jing , Chu Zhongyi 
Published: August 2023

Purpose
Accurate segmentation of artificial assembly action is the basis of autonomous industrial assembly robots. This paper aims to study the precise segmentation method of manual assembly action.

Design/methodology/approach
In this paper, a temporal-spatial-contact features segmentation system (TSCFSS) for manual assembly actions recognition and segmentation is proposed. The system consists of three stages: spatial features extraction, contact force features extraction and action segmentation in the temporal dimension. In the spatial features extraction stage, a vectors assembly graph (VAG) is proposed to precisely describe the motion state of the objects and relative position between objects in an RGB-D video frame. Then graph networks are used to extract the spatial features from the VAG. In the contact features extraction stage, a sliding window is used to cut contact force features between hands and tools/parts corresponding to the video frame. Finally, in the action segmentation stage, the spatial and contact features are concatenated as the input of temporal convolution networks for action recognition and segmentation. The experiments have been conducted on a new manual assembly data set containing RGB-D video and contact force.

Findings
In the experiments, the TSCFSS is used to recognize 11 kinds of assembly actions in demonstrations and outperforms the other comparative action identification methods.

Originality/value
A novel manual assembly actions precisely segmentation system, which fuses temporal features, spatial features and contact force features, has been proposed. The VAG, a symbolic knowledge representation for describing assembly scene state, is proposed, making action segmentation more convenient. A data set with RGB-D video and contact force is specifically tailored for researching manual assembly actions.
XPS™ Jensen lung as a low‐cost, high‐fidelity training adjunct to ex‐vivo lung perfusion
Authors: Gouchoe Doug A. , Shukrallah Basam , Eggeman Chad , Igoe David , Ralston James , Mast David , Ganapathi Asvin M. , Whitson Bryan A. 
Published: August 2023

AbstractBackgroundEx vivo lung perfusion (EVLP) enables lung resuscitation before transplantation, and training is key, particularly in low‐volume settings. To enable technique refinement and continuing education, we sought to demonstrate the value of a low‐cost, high‐fidelity EVLP simulator that would allow reproducible clinical scenarios.MethodsIn partnership with our EVLP manufacturer, we utilized the XPS™ Jensen Lung with our clinical system. The Jensen Lung has two simulated lung bladders and an in‐line polymethylpentene fiber oxygenator. It allows titration of ventilator support which aids in accurate clinical simulation. For simulations, blood gases (BGs) were obtained and compared with integrated in‐line perfusate gas monitors (PGMs). PaO2, PCO2, and pH were measured and compared.ResultsThe PGM and BG values were not significantly different throughout the range of FiO2 and sweep gas flow rates evaluated. The “delta” PaO2 was measured between LA and PA and did not show any change between approaches. The pH measurement between BG and PGM was not significantly different.ConclusionsThe XPS™ Jensen Lung simulator allows for a high‐fidelity simulator of clinical EVLP. The correlation of the PGM and the BG measurement of the PaO2 and pH allow for a low‐cost simulation, as the PGMs are in line in the circuit, and enable real‐time tracking of perfusate gas parameters with the PGM. Implementation of a standardized clinical EVLP training program allows the maintenance of technique and enables clinical simulation training without the need for costly animal perfusions and the use of multiple BG measurements.
Age at treatment initiation predicts response in children with chronic hepatitis B
Authors: Wu Xiaoli , Yao Zhenzhen , Lai Xin , Gu Yingping , Peng Songxu 
Published: August 2023

SummaryBackgroundAccumulating evidence suggests that age has a significant impact on disease progression and outcome of hepatitis B virus (HBV) infection. However, its effect on treatment response has not yet been fully elucidated.AimTo investigate the associations of age at treatment initiation with clinical treatment outcomes in children with chronic hepatitis B (CHB).MethodsThis study included 306 treatment‐naïve children with CHB. Participants were divided into three groups based on the age at which they started antiviral treatment: 1–3 years, 4–6 years and 7–17 years. The primary outcome of this study was HBsAg loss; secondary outcomes included HBeAg clearance and DNA undetectability.ResultsOf the 306 subjects, 200 (65.4%) were male. Median (IQR) duration of follow‐up was 26 (17, 42) months. There were 139 (45.4%), 79 (25.8%) and 88 (28.6%) of participants in the 1–3 years, 4–6 years and 7–17 years groups, respectively. After adjusting for other covariates, age at treatment initiation was negatively associated with the occurrence of HBsAg loss (1–3 years: HR = 5.07, 95% CI = 2.91–8.82; 4–6 years: HR = 2.42, 95% CI = 1.31–4.46) and HBeAg clearance (1–3 years: HR = 1.73, 95% CI = 1.18–2.53). In addition, we observed linear dose–responses relationships between age at treatment initiation and the probability of HBsAg loss and HBeAg clearance.ConclusionsIn children with CHB receiving antiviral treatment, HBsAg loss and HBeAg clearance were frequently observed. Age at treatment initiation can predict treatment response, including HBsAg loss and HBeAg clearance.
Human blood metabolites and risk of severe COVID‐19: A Mendelian randomization study
Authors: Shang Weifeng , Qian Hang , Shen Xuan , Wen Zhenliang , Zhang Sheng , Chen Dechang 
Published: August 2023

AbstractBackgroundEvidence supports the observational associations of human blood metabolites with the risk of severe COVID‐19. However, little is known about the potential pathological mechanisms and the analysis of blood metabolites may offer a better understanding of the underlying biological processes.MethodsWe applied a two‐sample Mendelian randomization (MR) analysis to evaluate relationships between 486 blood metabolites and the risk of severe COVID‐19. The inverse‐variance weighted (IVW) model was used as the primary two‐sample MR analysis method to estimate the causal relationship of the exposure on the outcome. Sensitivity analyses were implemented with Cochran's Q test, MR‐Egger intercept test, MR‐PRESSO, leave‐one‐out analysis and the funnel plot.ResultsFour hunderd and eighty six metabolites were included for MR analysis following rigorous genetic variants selection. After MR analyses and sensitivity analysis filtration, we found weak evidence of an association between 3‐hydroxybutyrate (odds ratio [OR] = 1.21, 95% CI, 1.07–1.38, p = .0036) and the risk of severe COVID‐19. A series of sensitivity analyses have been carried out to confirm the rigidity of the above results.ConclusionThis study suggested a causal relationship between 3‐hydroxybutyrate and the severity of COVID‐19, thus providing novel insights into biomarkers and pathways for COVID‐19 prevention and clinical interventions.
KOLONIALE GEOGRAFIE BEI DÖBLIN: DIE GRÜNDUNG DES BUNDES DER WAHRHAFT SCHWACHEN IM ZEICHEN DER KOHLE IM CHINESISCHEN ROMAN DIE DREI SPRÜNGE DES WANG‐LUN
Authors: Jiang Ying , Mardaus Frank 
Published: August 2023

ABSTRACTThe article examines Döblin's novelistic treatment of geographical information with regard to China. By means of sketches and choice quotations, proof was found that Döblin not only adopted findings by Ferdinand Baron von Richthofen, but implicitly stressed the German geographer's intention to utilise China's large coal deposits for colonial interests. The example of the Nan‐ku mountains, where in the novel the political/religious movement of the ‘Truly Weak’ alliance first formed itself, serves to examine how Döblin makes use of geological and historical facts from von Richthofen's scientific studies. This reveals itself, for instance, in his only slightly differing description of the Nan‐ku mountain range from what von Richthofen had noted. In its attempted exactitude, the former notion can be considered a typical feat of literary Realism. We also further examine the crucial role this much sought‐after Chinese mineral wealth – coal – plays in the later rebellious upheaval. Our results contradict the current notion that Döblin depicted a historically divested, contrapuntal view of China as compared to the Western Hemisphere. Instead, the novel markedly deals with real geographical, social and political facts about China in the colonial era. A merely expressionist view on Döblin's novel does not seem to hold.
Effects of a mobile application on improving self‐management of adult patients receiving peritoneal dialysis: A randomized controlled trial
Authors: Chae Yoon Jung , Kim Hee Sun 
Published: August 2023

AbstractAimThis study aimed to develop a mobile application for improving self‐management and to evaluate its effects in adult patients on peritoneal dialysis (PD).MethodsThis randomized controlled trial was registered with the Korean Clinical Research Information Service Registry (KCT0007267) and conducted at a tertiary hospital. A self‐management mobile application (SMA) was developed based on social cognitive theory and the ADDIE (analysis, design, development, implementation, and evaluation) model. The SMA includes information about disease management; self‐recording of data on diet, exercise, medication, and health behavior; and healthcare providers' support and feedback. Participants aged 19–65 years were randomly allocated to the intervention group (n = 27) using the SMA for 10 weeks, and the control group (n = 26) receiving usual care. PD‐related knowledge and self‐efficacy, PD‐related health behavior, biomarkers, and health‐related quality of life (HRQoL) were surveyed pretest/posttest and analyzed using SPSS 23.0.ResultsCompared to the controls, the intervention group showed significant improvement in PD‐related knowledge and health behavior, albumin, and hemoglobin. HRQoL domains of symptoms/problems of kidney disease and disease impact on daily activity were improved in the intervention group.ConclusionThe SMA is an effective intervention for enhancing health behaviors as well as improving the HRQoL of patients with PD. Without any limitations on time or location, patients with PD can easily use the SMA to monitor their health conditions, efficiently manage their disease, and perform PD‐related behaviors. Nurses can implement high‐quality tailored healthcare by using patients’ lifelog data from the SMA.
Confused subcutaneous nodules in children: Differential diagnosis of pilomatricoma in children
Authors: Sun Juan , Fu Li Bing , Xu Jiao Sheng , Han Xiao Feng , Wei Li 
Published: August 2023

AbstractBackgroundPilomatricoma is a common but easily misdiagnosed tumor in children.AimsTo differentiate pilomatricoma from other common subcutaneous nodules in children.Patients/MethodsMisdiagnosed subcutaneous nodules in four children were recorded.ResultsA red mass on a 7‐year‐old boy's head which had been misdiagnosed pyogenic granuloma was proved to be pilomatricoma. A red mass on an 8‐month‐old boy's face which had been misdiagnosed infantile hemangioma also turned to be pilomotricoma. A red mass on a 21‐month‐old girl's breast, which had been misdiagnosed pilomatricoma, was proved to be infantile myofibroma. A subcutaneous nodule under a 13‐month‐old girl's armpit, which had been misdiagnosed pilomatricoma, turned to be BCG‐associated lymphadenitis.ConclusionsWhen a child with a subcutaneous nodule attends, pilomatricoma, vascular tumors, fibrous tumors, and BCG‐associated lymphadenitis should be considered.
Mega‐events and human rights violations: Empirical evidence from the long‐term perspective
Authors: Ashyrov Gaygysyz , Ivanov Denis 
Published: August 2023

AbstractAs developing countries have started to host the mega‐events (e.g., FIFA, Olympics), the focus has shifted toward the human rights conditions in the host country rather than the competition itself. Up to now, far too little attention has been paid to the impact of mega‐events on human rights. This study aims to fill that gap by examining the relationship between mega‐events and human rights violations in hosting countries. By applying panel data techniques to a rich dataset, we find that hosting mega‐events has a positive impact on human rights. These findings remain statistically significant after several different specifications.
Socializing Influences in the Careers of South Korean Female Physical Educators
Authors: Lee Okseon , Richards Kevin Andrew , Hong Yeri , Kim Youngjoon 
Published: August 2023

Purpose: Grounded in the occupational socialization theory, this study explored how gender interacted with and influenced socialization experiences in the careers of South Korean female physical educators. Specific attention was directed toward the gendered experiences that female teachers experienced and the coping strategies to navigate them. Methods: The study adopted a qualitative case study design, and the participants were 15 female secondary school physical educators. Data were collected through life story timelines, critical incident writings, and individual interviews. Results: Four themes emerged: (a) unwelcomed and invisible; (b) experiencing a physicality-driven hierarchy; (c) dual marginalization as female physical educators; and (d) retreating, masking, redefining, or leaving to cope with challenges. Discussion/Conclusions: The findings indicated that female physical educators experienced being dual-marginalized due to the interplay between gender and subject matter. In response to the challenges, some conformed to their gender role to be safe; however, other teachers employed various strategies to overcome the status quo.