bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term risk of reoperation after modular hemiarthroplasty. Any differences between uni- or bipolar design?
Authors: Lind Dennis , Nåtman Jonatan , Mohaddes Maziar , Rogmark Cecilia 
Published: May 2023

Abstract
Background
It is unclear whether unipolar (UHA) or bipolar (BHA) hemiarthroplasty should be the preferred treatment of femoral neck fracture (FNF).
Aim
We investigated the reoperation rate at 13 years post-fracture after BHA and UHA as treatment of FNF, including a subgroup analysis of individuals who survived 5 years or more, and described the reasons for reoperation after BHA and UHA respectively.
Methods
In an observational cohort study on prospectively collected national register data, 16,216 BHA and 22,186 UHA were available for matching. A propensity score for treatment with bipolar HA was estimated using logistic regression. Matching was done using the 1:1 nearest neighbor matching without replacement. Of the 16,216 BHA patients, 12,280 were matched to a UHA control.
A subgroup analysis based on the matched sample excluded individuals who died within 5 years and comprised 3,637 individuals with BHA and 3,537 with UHA. Kaplan-Meier survival analysis was used.
Results
In the Kaplan-Meier analysis, 92% of the BHA group was free from reoperation at 13 years (95% CI 0.91-0.93), compared to 92% in the UHA group (CI 0.89-0.94). BHA was associated with more reoperations until 3 years. Reoperation due to infection was most common after BHA, n=212 (1.7%) compared to n=141 (1.1%) after UHA. Dislocation led to reoperation in 192 of the BHA cases (1.6%) and in 157 of the UHA cases (1.3%). Acetabular erosion/pain occurred in 0.1% and 0.4%.
Amongst those surviving ≥5 years, 93% of the BHA group was free from reoperation (CI 0.92-0.94) at 13 years, 92% after UHA (CI 0.90-0.94). BHA had more reoperations during the 1st year only. The causes for reoperations were similar results except for acetabular erosion/pain. Here the BHA group had 2 cases (0.1%), the UHA had 39 (1.1%).
Conclusion
With a modular hemiarthroplasty relatively few patients need a reoperation. During the first years, there is a higher reoperation rate after BHA compared to UHA. Thereafter, no differences are seen. In patients who survive ≥5 years after the fracture there are more reoperations due to acetabular erosion after UHA, but crude numbers are extremely low and the total reoperation rate is not affected.
Integration of Experimental Methods and Molecular Dynamics Simulations for a Comprehensive Understanding of Enhancement Mechanisms in Graphene Oxide (GO)/Rubber Composites
Authors: Fu Quansheng , Yang Zifan , Jia HongBing , Wen Yanwei , Luo Yanlong , Ding Lifeng 
Published: May 2023

Abstract
Graphene oxide (GO) exhibits great application in rubber industry due to its unique two-dimensional nanosheet structure, significant specific surface area, good barrier property, and high reactivity. However, different rubbers, such as carboxylated nitrile butadiene rubber (XNBR), natural rubber (NR), and styrene butadiene rubber (SBR), have different interactions with GO, which has great influence on the reinforcement effect of GO to the rubber matrix. In this work, the enhancement mechanism of GO on NR, SBR, and XNBR was studied by combining experiments with molecular dynamics (MD) simulation. The results show that GO/XNBR nanocomposites had the smallest potential energy difference (ΔWa), mean square displacement (MSD), and free volume fraction (FFV), resulting in excellent solvent resistance, and dynamic and mechanical properties. This study provides a new way to explore the macroscopic properties of rubber nanocomposites through molecular-level simulation.
A study of Machine Learning Methods Based Affective Disorder Detection using Multi-Class Classification
Authors: C Kishor Kumar Reddy , Tungana Bhavya , Hanafiah Marlia Mohd , Doss Srinath 
Published: May 2023

Abstract
Psychological health issues like stress, anxiety and depression is becoming general due to various factors. Different severity levels of stress, anxiety and depression have varied impacts on people, which can lead to suicidal ideation and suicide attempts. Demographic data consists of gender, age group, marital status, education, type of employment, economic status, and living status, and 21 questions about stress, anxiety, and depression, including scores, were considered for the dataset. The proposed K-nearest neighbor model achieved maximum accuracy with 94.5% for stress and anxiety and 97.7% for depression, compared with Naive Bayes's 81.8%, 81.5%, and 83.5% as minimum accuracy for stress, anxiety, and depression, respectively, as compared with other models.
Moisture Mitigation Using a Vented Liner and a Vented Socket System for Individuals with Transfemoral Amputation
Authors: Gnyawali Surya C. , Denune Jeffrey A. , Hockman Bryce , Kristjánsdóttir Jóna Valgerður , Ragnarsdóttir Margrét Sól , Timsina Lava R. , Ghatak Subhadip , Lechler Knut , Sen Chandan K. , Roy Sashwati 
Published: May 2023

Abstract
Sweating and heat buildup at the skin-liner interface is a major challenge for amputees. Liners made of heat-non-conducting materials cause sweating of the residual limb and may result in liners slipping off the skin surface, causing skin breakdown and affecting limb health. To address this, we evaluated the efficacy of the vented liner-socket system (VS, Össur) compared to Seal-In silicone liner and non-vented socket (nVS, Össur) in reducing relative humidity (RH) during increased perspiration. Nine amputees using nVS were randomized to VS or nVS in a 20-minute treadmill walk. RH was significantly attenuated (p < 0.0002) and perceived sweating improved (p < 0.05) with VS, patient-reported CLASS outcomes to determine the suspension, stability, comfort, and appearance were not significantly different between VS and nVS. There are limited rigorous scientific studies that clearly provide evidence-based guidelines to the prosthetist in the selection of liners from numerous available options. The present study is innovative in clearly establishing objective measures for assessing humidity and temperatures at the skin-liner interface while performing activity. This study provided maiden evidence that relative humidity at the skin-liner interface is reduced with the use of a vented liner-socket system when compared to a similar non-vented system.
Coix Seed Oil ameliorates synovial angiogenesis in collagen-induced arthritis rats through inhibiting HIF-1α / VEGF-A pathway via SIRT1
Authors: Xu Qiangqiang , Kong Hongxi , Ren Shuang , Meng Fanyan , Liu Ruoshi , Jin Hongxin , Zhang Jie 
Published: May 2023

Abstract
Background
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by symmetric arthritis. Coix Seed Oil (CSO) has been shown to reduce inflammation in rheumatoid arthritis (RA). However, the CSO impact on synovial angiogenesis in RA remains unclear. Therefore, this study aimed to study the CSO inhibitory impact on RA synovial angiogenesis and elucidate the corresponding mechanisms.
Methods
Collagen-induced arthritis (CIA) rat model was established by male Sprague-Dawley rats and then treated with different doses of CSO for four weeks. Arthritis Index (AI), paw swelling, and weight of rats were recorded to assess their clinical symptoms. Hematoxylin and Eosin (H&E) staining, immunohistochemical, and immunofluorescence staining were performed to observe changes in synovial tissues. The serum HIF-1α and VEGF-A protein were evaluated through enzyme-linked immunosorbent assay (ELISA). The FLS was stimulated with TNF-α for developing an in vitro inflammatory model. Cytotoxicity and cell viability were measured using a CCK8 test. Wound healing and Transwell migration experiments were employed to determine FLS migratory ability, together with Immunofluorescence was utilized to assess HIF-1α nuclear translocation within FLS. The SIRT1, HIF-1α, VEGF-A, together with CD31 expression profiles were assessed through Western blot assays. The isolated aortic rings were extracted to observe the CSO inhibitory impact on angiogenesis.
Results
CSO inhibited angiogenesis, together with HIF-1α and VEGF-A expression within CIA rat synovial tissue. Mechanistically, CSO regulated the HIF-1α / VEGF-A pathway by mediating SIRT1 expression, exerting anti-angiogenic effects in vitro and in vivo.
Conclusions
This study indicated that CSO could ameliorate synovial angiogenesis in CIA rats through inhibiting HIF-1α / VEGF-A pathway via SIRT1.
Uncovering the mechanisms of Yi Qi Tong Qiao Pill in the treatment of allergic rhinitis based on Network target analysis
Authors: Wang Boyang , Zhang DingFan , Zhang Tingyu , Sutcharitchan Chayanis , Hua Dongfang , Zhang Bo , Li Shao 
Published: May 2023

Abstract

Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM) from systematic perspective. Methods: Based on the data collected from TCM-related and disease-related databases, target profiles of compounds in YQTQP were calculated through network-based algorithms and holistic targets of TQTQP was constructed. Network target analysis was performed to explore the potential mechanisms of YQTQP in the treatment of AR and the mechanisms were classified into different modules according to their biological functions. Besides, animal and clinical experiments were conducted to validate our findings inferred from Network target analysis. Results: Network target analysis showed that YQTQP targeted 12 main pathways or biological processes related to AR, represented by those related to IL-4, IFN-γ, TNF-α and IL-13. These results could be classified into 3 biological modules, including regulation of immune and inflammation, epithelial barrier disorder and cell adhesion. Finally, a series of experiments composed of animal and clinical experiments, proved our findings and confirmed that YQTQP could improve related symptoms of AR, like permeability of nasal mucosa epithelium. Conclusion: A combination of Network target analysis and the experimental validation indicated that YQTQP was effective in the treatment of AR and might provide a new insight on revealing the mechanism of TCM against diseases. Details of trial registration: Name of the registry: Chinese Clinical Trial Registry Trial registration number: ChiCTR-TRC-13003137 Date of registration: Registered 29 March 2013 - Retrospectively registered, URL of trial registry record: https://www.chictr.org.cn/showproj.html?proj=6422
Glycyrrhiza Uralensis Polysaccharides Inhibits the cGAS-STING Signaling Pathway and Ameliorates Cecum Ligation and Puncture-induced Sepsis ​
Authors: Hui Siwen , Kan Wen , Qin Shuanglin , He Ping , Zhao Jia , Li Hui , Bai Jun , Wen Jincai , Mou Wenqing , Hou Manting , Wei Ziying , Xiao Xiaohe , Xu Guang , Bai Zhaofang 
Published: May 2023

Abstract
Sepsis is a disease of multiple organ dysfunction caused by infection. It threatens human health and is one of the major human mortality problems. Recent researches have shown that cGAS-STING pathway is involved in the development and progression of sepsis. Here, we report that Glycyrrhiza Uralensis Polysaccharides (GUP), one of the major components of licorice, has a protective effect against cecal ligation and puncture (CLP) sepsis in mice. We found that GUP reduced pathological changes in CLP sepsis-inducing tissues and the expression of genes downstream (IFN-β and TNF-α) of cGAS-STING pathway. Moreover, GUP significantly reduced the expression of IFN-β, IL-6 and TNF-α mediated by a mouse-specific activators of STING (DMXAA) in mice. In vitro studies, GUP inhibited the activation of the cGAS-STING pathway as evidenced by inhibition of the expression of related downstream genes, such as IFN-β, IL-6, TNF-α and interferon-stimulated genes (CXCL10). Mechanistically, GUP inhibited the activation of cGAS-STING pathway by inhibiting the interaction of STING with TBK1 and TBK1 with IRF3. In conclusion, our studies suggest that GUP is an effective inhibitor of the cGAS-STING pathway, which may be a potential medicine for the treatment of inflammatory diseases mediated by the cGAS-STING pathway.
How technical change has boosted Fish Aggregation Device productivity in the Indian Ocean tuna fishery
Authors: Tidd Alex N. , Floch Laurent , Imzilen Taha , Tolotti Mariana , Dagorn Laurent , Capello Manuela , Guillotreau Patrice 
Published: May 2023

Abstract
Excess harvesting power can threaten the long-term sustainability of fisheries. Indicators of excess harvesting power include input-output-based estimates of economic production efficiency. The increasing use of Fish Aggregating Devices (FADs) has boosted fishing productivity in high-seas tuna fisheries, perhaps beyond the biological capacity of the stocks, and is an object of global debate. We carried out a Data Envelopment Analysis of relative changes in production efficiencies of the French purse-seine fleet targeting tropical tuna in the western Indian Ocean using two fishing strategies, 1) on floating objects (FOB) and 2) free swimming schools (FSC) using tuna catch and effort data spanning 1992–2019. We show that FOB fishing evolved dramatically through time via the introduction of new technology with an estimated change of 4.2%yr− 1 (9.2%yr− 1 2007–2019), in contrast to 1.5%yr− 1 for FSC. While the level of efficiency in the use of inputs has barely changed for FOB fishing, a steady increase for FSC is observed. Factors that influence the productive capacity of vessels include the number of fishing sets, vessel power, fuel, and tuna price. Immediate plans to improve input-based management in this region are needed to prevent further risks of overfishing to yellowfin (Thunnus albacares) and skipjack (Katsuwonus pelamis) tunas.
Processing of ego-motion compatible optic flow in the elderly
Authors: Guénot Jade , Trotter Yves , Delaval Angélique , Baurès Robin , Soler Vincent , Cottereau Benoit 
Published: May 2023

Abstract
Aging impacts human observer’s performance in a wide range of visual tasks and notably in motion discrimination. Despite numerous studies, we still poorly understand how optic flow processing is impacted in the elderly. Here, we estimated motion coherence thresholds in two groups of young (age: 18–30, n = 42) and old (70–90, n = 42) adult participants for the three components of optic flow (translational, radial and rotational patterns). Stimuli were dynamic random-dot kinematograms (RDKs) projected on a large screen. Participants had to report their perceived direction of motion (leftward versus rightward for translational, inward versus outward for radial and clockwise versus anti-clockwise for rotational patterns). Stimuli had an average speed of 7°/s (additional recordings were performed at 14°/s) and were either presented full-field or with an artificial scotoma masking central vision. Statistical analyses showed that if thresholds in older adults were similar to those measured in younger participants for translational patterns, thresholds for radial patterns were significantly increased in our slowest condition and thresholds for rotational patterns were significantly decreased. Altogether, these findings support the idea that aging does not lead to a general decline in visual perception but rather has specific effects on the processing of each optic flow component.
CSMD1 mutation is associated with prognosis, tumor mutation burden, and immunophenotype in non-metastatic colorectal cancer
Authors: Liu Yi , Guo Yue , Yuan Quanliang , Zhang Qingdong , Cao Dongsheng , Wu Yijuan , Cheng Long , Han Ke 
Published: May 2023

Abstract
Colorectal cancer (CRC) is the leading cause of cancer-related death worldwide. Comprehensive clinical management and precise treatment for CRC patients are very important, which can significantly improve the survival rates of patients, especially those who have not developed distant metastases. The study is aimed to explore the relationship of somatic mutations with immune response and prognosis in non-metastatic CRC (non-mCRC) patients. We collected gene expression data, clinical information, and somatic mutation data from The Cancer Genome Atlas and the International Cancer Genome Consortium databases. We identified 16 mutated genes associated with non-mCRC that were common to both databases and calculated the tumor mutation burden (TMB). Kaplan-Meier survival analysis indicated that of the 16 mutant genes, CUB and Sushi multiple domains 1 (CSMD1) mutations are related to CRC prognosis, and this was confirmed by univariable and multivariable Cox regression analyses. Finally, we used gene set enrichment analysis (GSEA) to explore the association of CSMD1 mutations with immune response pathways, and also measured the tumor-infiltrating immune cell fractions and the key immune checkpoints expression. The results indicated that the CSMD1 mutation might activate the non-mCRC immune response. Thus, CSMD1 might be regarded as a promising biomarker to predict immune response in non-mCRC.
Factors affecting the use of dental services among Arab children in Israel: A qualitative study
Authors: Khatib Mohammad , Ashkenazi Yael , Loeff Yoav , Zusman Shlomo Paul , Natapov Lena 
Published: May 2023

Abstract
Background In 2010, Israel reformed its hitherto dominantly privately financed dental services and included preventative and restorative dental care for children in the publicly-funded basket of healthcare services. A survey conducted by Brookdale Institute, found that only 67% of low-income Israeli-Arab children were using the new service (compared to 85% of Jewish children) while the majority of others continue using privately funded services. The aim of this study is to explore and explain Israeli-Arab children's low utilization of publicly-funded preventive and restorative dental care.Methods A qualitative study designed to describe and understand the parents’ motivations and choices. As a preliminary stage, eight semi-structured interviews were conducted with directors of HMO dental departments and Israeli-Arab dentists. In the main part of the study, ten one-on-one interviews with parents, and five focus group discussions with 55 parents held February-March 2017. The parents were recruited through community settings. All discussions in the focus groups were conducted in Arabic and each group was moderated by one of the research team accompanied by another person who documented and recorded the discussion. All interviews and focus groups were recorded, transcribed in full and translated into Hebrew. A content analysis was done to explore key themes.Results The prevalent attitude is that one goes to the dentist only when there is a serious problem. The importance of preventive care is not appreciated. A childhood fear of the drill is very remembered and passed onto the children. Social and cultural factors such as kinship with service providers (GPs and dentists) influence the choice and utilization of health services. Economic barriers are still existing since even the small co-payment is daunting to low-income parents of large families. Provision of the public service is inadequate in some Arab villages.Conclusions The extension of Israel's National Health Insurance Law’s basket of services to include dental care for children, while important, is not sufficiently embraced by Israeli Arab children. The remaining barriers include poor living conditions, low educational level that requires very clear sharing of information about the new service, and the resistance of cultural and social traditions.
Recrystallization of triple superphosphate derived from waste mollusk shells to produce mono- and di- calcium phosphates in green and low-cost way
Authors: Seesanong Somkiat , Seangarun Chaowared , Boonchom Banjong , Sron Chuchai , Thompho Somphob , Rungrojchaipon Pesak , Boonmee Wimonmat , Laohavisuti Nongnuch 
Published: May 2023

Abstract
High consumption of mollusk shells generates many waste mollusk shells. To reduce and utilize these wastes, they can be cleaned and milled to produce calcium carbonate (CaCO3) powders, which can be further used as raw material for producing valuable products. This research presents a simple, cheap, and environmentally friendly preparation of calcium phosphates by using waste mollusk shells as a renewable source. All synthesized calcium phosphate samples were characterized and confirmed by X-ray fluorescence, X-ray diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, and thermal analysis. The addition of phosphoric acid to mollusk-derived CaCO3 generated triple superphosphate (TSP), which consisted of two or more calcium phosphate compounds. After the TSP powder was dissolved in water, non-soluble powders were obtained and found to be dicalcium phosphate dihydrate (DCPD, CaHPO4·2H2O). After removing non-soluble compounds and then the self-evaporating process of the solution fraction to dryness, the recrystallized product was investigated and confirmed as monocalcium phosphate monohydrate (MCPM, Ca(H2PO4)2·H2O). This recrystallization process produced highly purified Ca(H2PO4)2·H2O with high solubility and phosphorus content that can be used as an effective fertilizer. The green and low-cost preparation of calcium phosphates proposed in this research will be valuable to reduce waste mollusk shells by reforming them into value-added products. This information points out the viewpoint of a zero-waste operation for obtaining sustainable development, which could be selected as an effective technique for waste management and recycling.
Production, Statistical Evaluation and Characterization of Chitosanase from Fusarium oxysporum D18
Authors: Abedin Rania Mohamed Ahmed , Elwaly Doha R. M. Abd , El-Salam Ayat E. Abd 
Published: May 2023

Abstract
Purpose The present research work focuses on the extraction of chitosanase enzyme from soil fungi. Chitosan hydrolysis by chitosanase is one of the most effective methods to produce chitosan oligosaccharides which are new biomaterials that have many biological activities such as antitumor, antioxidant, antidiabetic and antimicrobial.
Method: A strain producing chitosanase was screened and identified as Fusarium oxysporum D18 with an accession number OL343607. Various physiological parameters (incubation type, carbon source, additive nitrogen source, statistical evaluation, solid state fermentation) were assessed to increase chitosanase production.
Results: Fusarium oxysporum D18 produced a considerable value of chitosanase, (1.220 U/ml). after 7 days of incubation, the best carbon source was lactose, and the best nitrogen source was ammonium chloride. Statistical evaluation was carried out by using Plackett-Burman and Box-Behnken designs. The highest chitosanase production, (1.994 U/ml) was induced by the medium composition g/L: KH2PO4 (1.5), MgSO4 (0.269), lactose (18), NH4Cl (1.26), pH (6.68), using a 5-day old inoculum and chitosanase activity was 1.63 folds that of the original medium. The production of chitosanase by Fusarium oxysporum D18 in solid state cultures using different solid substrates was studied and the best solid substrate for higher chitosanase activity (2.246 U/ml) was raw shrimp heads and shells and chitosanase activity was 1.13 folds that of the optimized liquid cultures. An extracellular chitosanase was isolated and partially purified by using 75 % saturation of ammonium sulphate. The highest chitosanase activity (3.667 U/ml) was obtained at enzyme protein concentration, (9.391 mg/ml), substrate concentration, (1.20%), Vmax of the enzyme was approximately (4.04 U/ml), km was (0.26%), at pH, (5.6) and reaction temperature, (50°C). The activity of the purified and characterized chitosanase increased by 3 times than that the original isolate activity. The enzyme was thermostable and retained about 55% of its original activity after heating at 70°C for 15 min. The enzyme preparations were activated by Ca2+ ions and inactivated by Zn+2, Cu+2 ions, and EDTA.
Conclusion: An antitumor activity of chitooligosaccharides produced by the chitosanase was applied to the MCF-7 (breast carcinoma cells) and they had a cytotoxicity inhibitory effect against them about IC50 = (448 μg/ml).