bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-compassion is associated with the superior longitudinal fasciculus in the mirroring network in healthy individuals
Authors: Hwang Yeong-Geon , Pae Chongwon , Song Chae Rim , Kim Hyun-Ju , Bang Minji , Park Chun Il , Choi Tai Kiu , Kim Min-Kyoung , Lee Sang-Hyuk 
Published: July 2023

AbstractSelf-compassion (SC) involves taking an emotionally positive attitude towards oneself when suffering. Although SC has positive effects on mental well-being as well as a protective role in preventing symptoms in healthy individuals, few studies on white matter (WM) microstructures in neuroimaging studies of SC has been studied. Brain imaging data were acquired from 71 healthy participants. WM regions of mirroring network were analyzed using tract-based spatial statistics. After the WM regions associated with SC were extracted, exploratory correlation analysis with the self-forgiveness scale, the coping scale, and the world health organization quality of life scale abbreviated version was performed. We found that self-compassion scale total scores were negatively correlated with the fractional anisotropy (FA) values of the superior longitudinal fasciculus (SLF) in healthy individuals. The self-kindness and mindfulness subscale scores were also negatively correlated with FA values of the same regions. These FA values were negatively correlated with the total scores of self-forgiveness scale, and self-control coping strategy and confrontation coping strategy. Our findings suggest levels of SC may be associated with WM microstructural changes of SLF in healthy individuals. These lower WM microstructures may be associated with positive personal attitudes, such as self-forgiveness, self-control and active confrontational strategies.
Evaluation of hackberry (Celtis australis L.) fruits as sources of bioactive compounds
Authors: Safari Farkhondeh , Hassanpour Hamid , Alijanpour Ahmad 
Published: July 2023

AbstractHackberry (Celtisaustralis L.) is native to the Mediterranean region and is distributed in Europe, Turkey, North Africa, and Iran. To the best of our knowledge, no study has been conducted on C.australis L. in the Arasbaran region, Iran. In the present study, total phenol (TP), flavonoid (TF), antioxidant capacity based on DPPH and FRAP assays and phenolic compounds and sugars profiles were investigated. According to the results, the range of antioxidant capacity based on DPPH and FRAP assays was 14.12–88.24% and 44.35–117.87 mg Fe2+/100 g, respectively. Also, the range of gallic acid, caffeic acid, chlorogenic acid, rutin, p-coumaric acid, rosmaric acid, cinnamic acid, and apigenin content was 2.59–26.32, 2.03–9.32, 0.94–11.35, 1.80–4.857, 2.32–9.52, 4.74–51.38, 0.18–2.10 and 0.27–1.37 mg/g, respectively. The results of factor analysis showed that the C12, C14, C15, C20, C8, C16, C3, and C20 genotypes are positively characterized by the first principal component (PCA1) that have a higher caffeic acid, chlorogenic acid, rutin, p-coumaric acid, rosmaric acid, quercetin, cinnamic acid, and apigenin phenolic compounds. Based on cluster analysis, the twenty genotypes were located in 2 main clusters. In general, the obtained results can be useful for breeding programs and the introduction of cultivars in Celtisaustralis L.
Electrophysiological evidence for sensitization effects elicited by concurrent social threats
Authors: Niedeggen Michael , Fang Xu , Yang Yu-Fang , Kerschreiter Rudolf 
Published: July 2023

AbstractExperiencing a social threat, such as social exclusion, is a painful event. In contrast to previous studies providing insight into the processing of a single short-termed threat, we exposed healthy individuals to the simultaneous onset of different social threats. This approach allowed us to track whether these threats are processed independently—or whether they interact in a common system. Using a virtual ball-throwing game (Cyberball), electrophysiological (event-related brain potentials, ERPs) and behavioral (self-reports) responses were collected. We assigned undergraduates to three experimental groups: single threat exclusion (n = 24), single threat loss of control (n = 26), and joint onset of both threats (dual-threat, n = 25). Self-reports indicated an increase in threats (i.e., in perceived exclusion and loss-of-control) in the latter group. The ERPs disentangled the neural responses to each threat: In the dual-threat group, the amplitudes of the P3 responses to exclusionary and intervention events were enhanced. This indicates that individuals are sensitized to each of the threats when the other threat is present simultaneously. Our findings support the theoretical notion of a common cognitive system responding to violations in subjective expectations.
Exploring the association between selective serotonin reuptake inhibitors and rhabdomyolysis risk based on the FDA pharmacovigilance database
Authors: Wang Yan , Lin Yajing , Lin Qing , Liang Haiming , Cai Weiming , Jiang Dongbo 
Published: July 2023

AbstractRhabdomyolysis is a syndrome potentially fatal and has been associated with selective serotonin reuptake inhibitors (SSRIs) treatment in a few case reports. Herein, we purpose to establish the correlation between SSRIs use and rhabdomyolysis using the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database. We conducted an analysis on reports that were submitted to the FAERS database during the period between January 1, 2004, and December 31, 2022. Four algorithms, including reporting odds ratio (ROR), proportional reporting ratio (PRR), Bayesian confidence propagation neural network (BCPNN), and empirical Bayes geometric mean (EBGM), were employed to quantify the signals of rhabdomyolysis associated with SSRIs. In total, 16,011,277 non-duplicated reports were obtained and analyzed. Among 33,574 reports related to rhabdomyolysis, SSRIs were classified as primary suspected drug in 889 cases. Disproportionality analysis identified a positive signal between rhabdomyolysis and SSRIs (ROR: 2.86, 95% CI 2.67–3.05; PRR: 2.84, χ2: 1037.16; IC0.25 = 1.39; EBGM0.5 = 2.64). Among six SSRIs, fluvoxamine had the strongest signal (ROR: 11.64, 95% CI 8.00–16.93; PRR: 11.38, χ2: 265.51; IC0.25 = 2.41; EBGM0.5 = 8.31), whereas no significant signal of rhabdomyolysis was detected for paroxetine (ROR: 1.83, 95% CI 1.55–2.15; PRR: 1.82, χ2: 53.82; IC0.25 = 0.73; EBGM0.5 = 1.59). After excluding cases co-administered with statins, the signal of rhabdomyolysis associated with SSRIs remains significant. Our analysis reveals that there are differences in safety signals among six SSRIs in respect to the risk of rhabdomyolysis, with fluvoxamine displaying the highest risk signal, while paroxetine did not show a significant signal. Given the potentially lethal nature of rhabdomyolysis, healthcare professionals should inform patients of the potential risk of rhabdomyolysis associated with SSRIs prior to initiating treatment.
5-Aminosalicylic acid alters the gut microbiota and altered microbiota transmitted vertically to offspring have protective effects against colitis
Authors: Wada Haruka , Miyoshi Jun , Kuronuma Satoshi , Nishinarita Yuu , Oguri Noriaki , Hibi Noritaka , Takeuchi Osamu , Akimoto Yoshihiro , Lee Sonny T. M. , Matsuura Minoru , Kobayashi Taku , Hibi Toshifumi , Hisamatsu Tadakazu 
Published: July 2023

AbstractAlthough many therapeutic options are available for inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) is still the key medication, particularly for ulcerative colitis (UC). However, the mechanism of action of 5-ASA remains unclear. The intestinal microbiota plays an important role in the pathophysiology of IBD, and we hypothesized that 5-ASA alters the intestinal microbiota, which promotes the anti-inflammatory effect of 5-ASA. Because intestinal inflammation affects the gut microbiota and 5-ASA can change the severity of inflammation, assessing the impact of inflammation and 5-ASA on the gut microbiota is not feasible in a clinical study of patients with UC. Therefore, we undertook a translational study to demonstrate a causal link between 5-ASA administration and alterations of the intestinal microbiota. Furthermore, by rigorously controlling environmental confounders and excluding the effect of 5-ASA itself with a vertical transmission model, we observed that the gut microbiota altered by 5-ASA affected host mucosal immunity and decreased susceptibility to dextran sulfate sodium-induce colitis. Although the potential intergenerational transmission of epigenetic changes needs to be considered in this study, these findings suggested that alterations in the intestinal microbiota induced by 5-ASA directed the host immune system towards an anti-inflammatory state, which underlies the mechanism of 5-ASA efficacy.
Comparing the signaling and transcriptome profiling landscapes of human iPSC-derived and primary rat neonatal cardiomyocytes
Authors: Bourque Kyla , Jones-Tabah Jace , Pétrin Darlaine , Martin Ryan D. , Tanny Jason C. , Hébert Terence E. 
Published: July 2023

AbstractThe inaccessibility of human cardiomyocytes significantly hindered years of cardiovascular research efforts. To overcome these limitations, non-human cell sources were used as proxies to study heart function and associated diseases. Rodent models became increasingly acceptable surrogates to model the human heart either in vivo or through in vitro cultures. More recently, due to concerns regarding animal to human translation, including cross-species differences, the use of human iPSC-derived cardiomyocytes presented a renewed opportunity. Here, we conducted a comparative study, assessing cellular signaling through cardiac G protein-coupled receptors (GPCRs) in rat neonatal cardiomyocytes (RNCMs) and human induced pluripotent stem cell-derived cardiomyocytes. Genetically encoded biosensors were used to explore GPCR-mediated nuclear protein kinase A (PKA) and extracellular signal-regulated kinase 1/ 2 (ERK1/2) activities in both cardiomyocyte populations. To increase data granularity, a single-cell analytical approach was conducted. Using automated high content microscopy, our analyses of nuclear PKA and ERK1/2 signaling revealed distinct response clusters in rat and human cardiomyocytes. In line with this, bulk RNA-seq revealed key differences in the expression patterns of GPCRs, G proteins and downstream effector expression levels. Our study demonstrates that human stem cell-derived models of the cardiomyocyte offer distinct advantages for understanding cellular signaling in the heart.
Photocatalytic properties of BiFeO3 powders synthesized by the mixture of CTAB and Glycine
Authors: Asefi N. , Hasheminiasari M. , Masoudpanah S. M. 
Published: July 2023

AbstractHighly pure BiFeO3 (BFO) powders were prepared by the solution combustion synthesis method using cetyltrimethylammonium bromide (CTAB) and glycine as fuels at various fuel-to-oxidant (φ) ratios. Microstructural characteristics, morphology, optical properties, and thermal analysis were studied by X-ray diffraction (XRD), scanning electron microscopy (SEM), diffuse reflectance spectroscopy (DRS), and differential thermal/thermogravimetry (DTA/TGA), respectively. The combusted powders prepared at different fuel content contained a small amount of impurity phases such as Bi24Fe2O39 and Bi2Fe4O9. During the calcination of BFO powders at 600 °C for 1 h, a nearly pure BFO phase was produced. Combusted powders photodegraded about 80% of methylene blue dye at φ = 2 through 90 min of visible light irradiation.
Six states of Enterococcus hirae V-type ATPase reveals non-uniform rotor rotation during turnover
Authors: Burton-Smith Raymond N. , Song Chihong , Ueno Hiroshi , Murata Takeshi , Iino Ryota , Murata Kazuyoshi 
Published: July 2023

AbstractThe vacuolar-type ATPase from Enterococcus hirae (EhV-ATPase) is a thus-far unique adaptation of V-ATPases, as it performs Na+ transport and demonstrates an off-axis rotor assembly. Recent single molecule studies of the isolated V1 domain have indicated that there are subpauses within the three major states of the pseudo three-fold symmetric rotary enzyme. However, there was no structural evidence for these. Herein we activate the EhV-ATPase complex with ATP and identified multiple structures consisting of a total of six states of this complex by using cryo-electron microscopy. The orientations of the rotor complex during turnover, especially in the intermediates, are not as perfectly uniform as expected. The densities in the nucleotide binding pockets in the V1 domain indicate the different catalytic conditions for the six conformations. The off-axis rotor and its’ interactions with the stator a-subunit during rotation suggests that this non-uniform rotor rotation is performed through the entire complex.
Intermediate states in Andreev bound state fusion
Authors: Jünger Christian , Lehmann Sebastian , Dick Kimberly A. , Thelander Claes , Schönenberger Christian , Baumgartner Andreas 
Published: July 2023

AbstractHybridization is one of the most fundamental quantum mechanical phenomena, with the text book example of binding two hydrogen atoms in a hydrogen molecule. Here we report tunnel spectroscopy experiments illustrating the hybridization of another type of discrete quantum states, namely of superconducting subgap states that form in segments of a semiconducting nanowire in contact with superconducting reservoirs. We discuss a collection of intermediate states with unique (tunnel) spectroscopic fingerprints in the process of merging well-known individual bound states, hybridized by a central quantum dot and eventually coherently linking the reservoirs, carrying a Josephson current. These coupled and fused Andreev bound states can be seen as superconducting analogues to atomic and molecular single electron states in nature, and explain a variety of recent bound state spectra, with specific fingerprints that will have to be winnowed in future Majorana fusion experiments.
Recast Therapy for Treating Syntax in Bilingual Children With Developmental Language Disorder: A Feasibility and Early Efficacy Study Examining the Role of Language of Intervention on Outcomes
Authors: Castilla-Earls Anny , Owen Van Horne Amanda 
Published: July 2023

Purpose:
The purpose of this study is to examine the feasibility of the delivery of complex syntax recast therapy via telepractice to Spanish–English bilingual children and provide preliminary evidence of the efficacy of this approach.

Method:

Fifteen bilingual children with developmental language disorders were stratified based on language proficiency and randomized to one of three treatment conditions: Spanish only (
n
= 5), English only (
n
= 6), or Spanish + English (
n
= 4). Using a within-subject design, we hypothesized that we could document treatment efficacy based on change in the treated structure in the absence of change in an untreated comparison structure. All 15 children completed ~16 hr of treatment via telepractice and participated in pre- and posttesting of their production of conditional adverbs (treated structure) and subject relative clauses (untreated structure) carried out by a masked assessor.

Results:
Analyses included all participants. Treatment fidelity was high, and participant attendance was remarkable, indicating feasibility. Regarding efficacy, recast therapy led to group-level gains on treated syntactic structures that exceeded those observed for the untreated comparison structure. For the 11 children who received therapy in only one language, approximately equal gains were observed in both the treated and untreated languages for conditional adverbials.

Conclusions:
Preliminary evidence suggests that for highly overlapping structures like conditional adverbials, recast therapy is effective and leads to change in both of the child's languages. Larger studies are required to understand how language of administration and proficiency may affect outcomes.

Supplemental Material:

https://doi.org/10.23641/asha.23739996
An improved discrete Fourier transformation channel estimation algorithm with low complexity for orthogonal frequency division multiplexing‐based power line carrier communication systems
Authors: Fan Gao , Yu Zhou , Shuangshuang Zhao , Yue Li , Xiao Chen , Chao Zhou , Xiang Wang , Zhen Zhang 
Published: July 2023

AbstractOrthogonal frequency division multiplexing (OFDM) technology has been increasingly applied to power line carrier communication (PLC). Discrete Fourier Transformation (DFT)‐based channel estimation algorithm is suitable for OFDM‐based PLC due to its low complexity. In view of the problem that the traditional DFT channel estimation does not consider the influence of noise inside cyclic prefix (CP), an improved DFT channel estimation based on signal‐to‐noise ratio (SNR) estimation is proposed. First, least‐square (LS) algorithm is performed and the frequency domain channel estimation is converted to the time domain through inverse DFT, and the average SNR of the system is estimated according to the pilot sequence. Second, the substitute SNR for each sample point inside CP is defined and used to filter impulse noise inside CP. Third, the average SNR is converted into the threshold of the useful signal energy inside CP, and the widespread background noise inside CP is filtered. The simulation results show that the proposed algorithm can obtain more accurate channel estimation than other DFT channel estimation algorithms because it can effectively filter out noise inside CP. In addition, compared with other similar algorithms, the proposed algorithm dose not result in a significant increase in complexity.
Towards the application of renewable energy technologies in green ports: Technical and economic perspectives
Authors: Parhamfar Mohammad , Sadeghkhani Iman , Adeli Amir Mohammad 
Published: July 2023

AbstractWith growing concerns over environmental degradation and climate change, the shipping industry is under increasing pressure to reduce its environmental impact. This has led to the development of green port initiatives in the field of maritime transport and logistics, which aim to promote sustainable practices and reduce the environmental footprint of ports and their operations. One of the key strategies for achieving this goal is the use of renewable energy technologies (RETs). This paper summarizes the potentials, challenges, and economic analysis of RETs applications in green ports, emphasizing those that require aquatic environments for operation, including floating photovoltaic systems, offshore wind turbines, and ocean energy. The paper investigates the concept of green ports and explores the feasibility of integrating RETs into these facilities. Also, the potential of the various RETs is presented in terms of technical and economic aspects and installed capacity. Additionally, due to high flexibility in electrical systems and compatibility with maritime transportation, the use of fuel cells in green ports has been discussed as a feasible solution for supplying power to ports (either as the primary or backup source). The findings of this study show that RETs can significantly contribute to achieving sustainable goals in the maritime industry and pave the way for the creation of more efficient and environmentally friendly ports.
Variability of the slow solar wind: New insights from modelling and PSP-WISPR observations
Authors: Poirier Nicolas , Réville Victor , Rouillard Alexis P. , Kouloumvakos Athanasios , Valette Emeline 
Published: July 2023

Aims. We analyse the signature and origin of transient structures embedded in the slow solar wind, and observed by the Wide-Field Imager for Parker Solar Probe (WISPR) during its first ten passages close to the Sun. WISPR provides a new in-depth vision on these structures, which have long been speculated to be a remnant of the pinch-off magnetic reconnection occurring at the tip of helmet streamers.
Methods. We pursued the previous modelling works of Réville et al. (2020, ApJ, 895, L20; 2022, A&A, 659, A110) that simulate the dynamic release of quasi-periodic density structures into the slow wind through a tearing-induced magnetic reconnection at the tip of helmet streamers. Synthetic WISPR white-light (WL) images are produced using a newly developed advanced forward modelling algorithm that includes an adaptive grid refinement to resolve the smallest transient structures in the simulations. We analysed the aspect and properties of the simulated WL signatures in several case studies that are typical of solar minimum and near-maximum configurations.
Results. Quasi-periodic density structures associated with small-scale magnetic flux ropes are formed by tearing-induced magnetic reconnection at the heliospheric current sheet and within 3 − 7 R⊙. Their appearance in WL images is greatly affected by the shape of the streamer belt and the presence of pseudo-streamers. The simulations show periodicities on ≃90 − 180 min, ≃7 − 10 h, and ≃25 − 50 h timescales, which are compatible with WISPR and past observations.
Conclusions. This work shows strong evidence for a tearing-induced magnetic reconnection contributing to the long-observed high variability of the slow solar wind.
The Early Postoperative Course of Cognitive Function and Preoperative Cerebrovascular Reserve
Authors: Ikota Masashi , Ishikawa Mami , Kusaka Gen 
Published: July 2023

Abstract
Background Patients with severe steno-occlusive disease of a main cerebral artery without causative lesions on magnetic resonance imaging (MRI) often develop cognitive impairment. However, the effects of revascularization surgery and the source of the cognitive impairment remain unclear. Therefore, we investigated the early postoperative course of cognitive function and its association with cerebral blood flow (CBF), cerebrovascular reserve (CVR), white matter disease (WMD), lacunar infarction, and cerebrovascular risk factors.
Methods Cognitive function was examined using neurobehavioral cognitive status examination (COGNISTAT) in 52 patients with steno-occlusive disease of a main cerebral artery before and at 6 months after superficial temporal artery–middle cerebral artery (STA–MCA) anastomosis. We examined how cognition changed before and at 1, 3, and 6 months after STA–MCA anastomosis in 27 of 52 patients. CVR and CBF were calculated from 123I-N-isopropyl-p-iodoamphetamine single photon emission computed tomography, in addition to other cerebrovascular risk factors in 34 of 52 patients. Cerebral infarction and WMD (periventricular hyperintensity [PVH] and deep subcortical white matter hyperintensity) were also evaluated preoperatively by MRI.
Results COGNISTAT scores improved at 1 month after STA–MCA anastomosis in patients with severe steno-occlusive disease of a main cerebral artery. Multiple stepwise regression analysis revealed that CVR (regression coefficient = –2.237, p = 0.0020) and PVH (regression coefficient = 2.364, p = 0.0029) were the best predictors of postoperative improvement in COGNISTAT scores (R
2 = 0.415; p = 0.0017).
Conclusion Cognitive function improves in relation to preoperative CVR and PVH early after STA–MCA anastomosis in patients with steno-occlusive disease of a main cerebral artery.