bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Ergonomic Posture and Repetition with Low Back Pain Complaints in Bakers
Authors: Khairani Rahmadina , Silaban Gerry , Syahri Isyatun Mardhiyah 
Published: August 2023

Abstrak
Postur tidak ergonomik dan repetisi dalam bekerja meningkatkan resiko mengalami keluhan low back pain. Tujuan penelitian ini ialah menganalisis hubungan postur tidak ergonomik dan repetisi dengan keluhan low back pain pada pembuat kue. Penelitian ini merupakan observational analitik dengan pendekatan cross-sectional. Populasi dalam penelitian ini adalah 69 orang, sementara sampel sebesar 62 orang dipilih dengan purposive sampling dengan mempertimbangkan kriteria inklusi. Keluhan low back pain diukur dengan instrumen Visual Analog Scale serta pemeriksaan fisik sederhana berupa pemeriksaan spasme otot punggung bawah, tungkai atas, tungkai bawah dan dilanjutkan dengan lesegue test. Postur tidak ergonomik dan repetisi diukur menggunakan lembar observasi RULA dan timer. Analisis data yang digunakan adalah uji Pearson. Hasil penelitian menunjukkan bahwa ada hubungan positif yang signifikan antara postur tidak ergonomi dan repetisi dengan keluhan low back pain (p=0.010; p=0.041<0,05). Penelitian ini dapat memberikan informasi sebagai bahan pertimbangan kepada pemilik usaha dalam mengambil kebijakan terkait kesehatan kerja khususnya low back pain serta dapat meningkatkan kesadaran pekerja untuk memperhatikan pola hidup yang sehat serta aktifitas fisik guna meminimalisir risiko nyeri.
Kata kunci: low back pain, postur, repetisi
Abstract
A posture that is not ergonomic and repetitive at work increases the risk of experiencing low back pain complaints. The study aimed to analyze the correlation between non-ergonomic posture and repetition with complaints of low back pain in cake makers. The study was an observational analytic with a cross-sectional approach. The population was 69 people, 62 samples were selected by purposive sampling with the inclusion criteria. Complaints of low back pain were measured using the Visual Analog Scale instrument as well as a simple physical examination in the form of examining the muscle spasms of the lower back, upper limbs, lower legs and followed by a lesegue test. Non-ergonomic postures and repetitions were measured using the RULA observation sheet and a timer. The data analysis used the Pearson test. There was a significant positive correlation between non-ergonomic posture and repetition with complaints of low back pain (p=0.010; p=0.041<0.05). This research can provide information as material for consideration to business owners in making policies related to occupational health, especially low back pain, and can increase worker awareness to pay attention to a healthy lifestyle and physical activity to minimize the risk of pain.
Keywords: low back pain, posture, repetition
Comparison of Effect of Conventional Medical Management and Ivabradine with Conventional Medical Management on Quality of Life in Patients with Chronic Heart Failure
Authors: Ghosh Rita , Ghose Rajesh Kumar , Karim Md Rezaul , Ara Shahin , Haque Md Azizul , Haque Md Nazmul , Joysoual Mita Rani 
Published: August 2023

Background: The study aimed to see the effectiveness and role of ivabradine on the quality of life in chronic heart failure suffering patients. This open-label Randomized controlled Trial was conducted to assess the effect of ivabradine plus conventional medical management over conventional medical management on quality-of-life parameters among 100 patients of chronic heart failure from January 2021 to December 2021 in the Department of Pharmacology & Therapeutics in collaboration with the Department of Cardiology & Medicine, Rajshahi Medical College Hospital, Rajshahi.
Materials and methods: According to the drug allocation study population was divided into a control group (50 patients) and an experimental group (50 patients). Minnesota Living with Heart Failure questionnaire (MLWHFQ) was used to assess the quality of life, and the resting heart rate was measured by 12-lead electrocardiography. Baseline demographic and clinical characteristics were recorded, and patients were followed up at four weeks and 12 weeks of treatment.
Results: The comparison of mean differences of MLWHFQ score at first and second follow-up visits between the two study groups was statistically significant [t (100) = 2.43 p < 0.05 & t (100) = 6.60 p < 0.001 respectively]. According to the MLWHFQ cut-point score, it was also observed that poor baseline quality of life gradually shifted to good quality after four weeks and 12 weeks of treatment, and it was proportionately higher in the experimental group. Relations between the respondents of both study groups and their different qualities of life during the first follow-up visit (x2 = 13.69, df = 2, p < 0.05) and second follow-up visit (x2 = 22.79, df = 2, p < 0.001) were statistically significant.The comparison of the mean (±SD) heart rate between the two study groups was statistically significant (p <0.001) only during the second follow-up visit.
Conclusion: This study concluded that adding ivabradine to conventional medical management in treating patients with chronic heart failure improves their symptoms, quality of life, and heart rate and ultimately reduces the morbidity and mortality of such patients.
TAJ 2022; 36: No-1: 1-8
Antimicrobial Susceptibility Patterns of Klebsiella Species Causing Urinary Tract Infections in Pregnant Women
Authors: Haque Quazi Tamanna , Alam Md Shah , Sazzad Jarin , Ali Md Tamjid , Haque Md Ahsanul , Rahman Md Mizanur , Nadi Sumona Raisa 
Published: August 2023

Background: Urinary tract infections (UTIs) are the most prevalent type of infection during pregnancy and are notoriously difficult to treat. Significant maternal and fetal risk is associated with UTI during pregnancy, with the most prevalent clinical manifestations being asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis.
Objectives: To identify Klebsiella species causing urinary tract infection among pregnant women and its antimicrobial susceptibility pattern by modified Kirby Bauer disc diffusion method in Rajshahi Medical College Hospital.
Materials and Method: A descriptive cross-sectional study was conducted between July 2021 to June 2022 in the Microbiology Department of Rajshahi medical college and the Gynecology and Obstetrics Department of RMCH to determine the antimicrobial susceptibility pattern of Klebsiella species causing urinary tract infection in pregnant women. The urine samples were inoculated onto MacConkeys agar, blood agar, nutrient agar, and chromogenic UTI agar media and incubated aerobically at 370 C overnight (18-20 hrs).
Results: In all trimesters, 294 urine samples were obtained from pregnant women with asymptomatic and symptomatic UTIs. Among the 114 (38.77%) culture-positive samples, 111 (97.36%) were single isolates, whereas 3 (2.63%) included multiple isolates. Klebsiella spp. comprised 21 out of 117 culture-positive bacterial isolates (17.94%). Regarding antimicrobial susceptibility testing, Klebsiella spp. demonstrated a significant degree of sensitivity to meropenem and nitrofurantoin. In this investigation, Klebsiella spp. was found to be the cause of bacteriuria among pregnant women.
Conclusion: Doctors should adhere to the antimicrobial susceptibility test results when selecting the appropriate medications to treat pregnant women with UTIs.
TAJ 2022; 36: No-1: 41-46
Determination of Minimum Inhibitory Concentration of Different Antibiotics against Pseudomonas aeruginosa by E- test at a Tertiary Care Hospital
Authors: Khatun Mst Romena , Alam Kh Md Faisal , Nahar Sabera Gul , Begum Nurjahan , Shahrear Md Khaled , Hauqe Quazi Tamanna 
Published: August 2023

Background: Antimicrobial drug resistance is a matter of worldwide concern. Different microorganisms, including bacteria, are becoming more resistant day by day. So it is of utmost importance to know the antimicrobial susceptibility pattern not only for initiation of treatment but also for prevention of drug resistance. By determining minimum inhibitory concentration (MIC) by Epsilometer-test (E-test), we can determine the exact dose of a particular drug.
Aims: The study is aimed to determine the MIC of different antibiotics against intermediate isolates of P. aeruginosa isolated from clinically suspected patients of chronic suppurative otitis media (CSOM).
Materials and Methods: A cross-sectional type of descriptive study was conducted in the Department of Microbiology, Rajshahi Medical College, Rajshahi, during the period of January 2019 to December 2019 to identify the causative bacteria of CSOM with their antibiotic susceptibility pattern. A total of 96 aural swabs were collected from clinically suspected cases of CSOM, irrespective of age and sex, in the ENT department of Rajshahi Medical College Hospital, Rajshahi. Isolation and identification of bacteria were made as per standard procedure, and then antimicrobial susceptibility testing was performed by the disc diffusion method. At last, E-test was performed on different antibiotics against intermediate isolates of P. aeruginosa.
Results: Among 73 isolates, 37 showed intermediate susceptibility towards selected antibiotics such as beta-lactams (Ceftazidime, Ceftriaxone), aminoglycosides (Gentamicin), and quinolones (Ciprofloxacin) by disc diffusion method. Among 37 intermediate isolates, P. aeruginosa was 14 in number. Regarding MIC breakpoints in terms of susceptibility, out of 14 intermediate isolates of P. aeruginosa, 09(64.28%) isolates were susceptible, 03(21.43%) intermediate, and 2(14.28%) were resistant to different antibiotics by E-test.
Conclusion: In this study, higher susceptibility of different antibiotics against intermediate isolates of P. aeruginosa was observed by E-test than the disc diffusion method.
TAJ 2022; 36: No-1: 47-54
Kualitas Mikrobiologi Udara di Ruang Perawatan Rumah Sakit
Authors: Islam Fahrul , Pala’langan Yusri , Chairani Hairuddin Miftah 
Published: August 2023

Latar Belakang: Rumah sakit mempunyai fungsi menyelenggarakan pelayanan pengobatan dan pemulihan kesehatan sesuai dengan standar pelayanan rumah sakit. Udara sebagai komponen lingkungan yang penting dalam kehidupan perlu dipelihara dan ditingkatkan kualitasnya sehingga memberikan daya dukung bagi makhluk hidup untuk hidup secara optimal. Tujuan: Penelitian ini bertujuan untuk mengetahui kualitas miktobiologi udara di ruang perawatan Rumah Sakit Bhayangkara Mamuju. Metode: Jenis penelitian observasi laboratorik dengan rancangan deskriptif. Sampel pada penelitian ini sebanyak 4 ruangan perawatan yang terdiri dari ruangan kelas I, kelas II, kelas III dan VIP. Pengambilan sampel menggunakan metode purposive sampling. Pengambilan sampel dilakukan sebanyak 2 kali, yaitu pada saat pagi hari dan sore hari. Hasil: Penelitian ini menemukan hasil bahwa angka kuman di pagi hari pada ruangan kelas I, kelas II, kelas III dan VIP, adalah 550 CFU/m3, 955 CFU/m3, 510 CFU/m3,dan 412 CFU/m3. Sedangkan angka kuman di sore hari pada ruangan kelas I, kelas II, kelas III dan VIP, adalah 510 CFU/m3, 770 CFU/m3, 315 CFU/m3, dan 385 CFU/m3. Rata-rata kelembaban pada ruang perawatan yaitu 56,5%. Rata-rata pengukuran suhu pada ruang perawatan sebesar 28⁰C. Rata-rata pencahayaan pada ruang perawatan sebesar 147 lux. Kesimpulan: Kualitas mikrobiologi udara yang tidak memenuhi syarat adalah angka kuman pada ruang perawatan kamar kelas II, yaitu sebesar 955 CFU/m3.
Gambaran Kadar Cholinesterase dalam Darah Petani Sawah di Desa Buraen Kabupaten Kupang
Authors: Tangkelangi Marni , Rantesalu Agnes 
Published: August 2023

Latar Belakang: Paparan pestisida merupakan hal yang tidak dapat dihindarkan dari pekerjaan petani. Penggunaan pestisida sebagai salah satu metode untuk mengendalikan hama pada tanaman padi memiliki resiko terjadinya paparan pada petani yang dapat menimbulkan keracunan yang dapat dideteksi dengan pemeriksaan cholinesterase dari darah petani. Tujuan: Tujuan penelitian ini untuk mengetahui gambaran kadar cholinesterase dari darah petani di Desa Buraen. Metode: Penelitian menggunakan desain analitik observasional dengan pendekatan cross sectional, sampel penelitian yaitu 15 orang petani sawah yang telah menjalankan pekerjaan minimal 10 tahun, dilakukan pengambilan darah vena kemudian serum diperiksa menggunakan instrument Photometer 5010 dengan metode Optikal DGKC dengan nilai rujukan laki-laki: 4.620 U/L – 11.500 U/L dan perempuan: 3.930 U/L – 10.800 U/L. Hasil: Hasil penelitian ditemukan 80% penurunan aktifitas cholinesterase terutama pada petani laki-laki, berusia 51-60 tahun serta masa kerja kurang dari 15 tahun. Kesimpulan: Kesimpulan kadar cholinesterase pada sebagain besar petani sawah di Desa Buraen abnormal.
Dampak Timbulan Sampah Di Tempat Pembuangan Akhir (TPA) Wonorejo Kabupaten Wonosobo Terhadap Lingkungan Tanah
Authors: Annita Anissa Valenia , Lestari Ayu , Adi Nugroho Prasetya 
Published: August 2023

ABSTRAK
Latar Belakang: Pertambahan jumlah penduduk diiringi dengan kegiatan masyarakat menyebabkan banyaknya kuantitas sampah menjadi bertambah, sampah yang melebihi kapasitas jika tidak ditangani dengan baik akan menjadi masalah, tidak hanya berdampak pada masyarakat tetapi berdampak juga pada lingkungan tanah. Tujuan: Penelitian ini bertujuan untuk mengetahui penyebab timbulan sampah yang melebihi kapasitas, bagaimana dampak timbulan sampah di TPA Wonorejo terhadap tanah. Metode: Pada penelitian ini menggunakan jenis penelitian kualitatif deskriptif dengan teknik pengambilan data observasi, mengidentifikasi warna tanah dan struktur tanah yang dialakukan secara langsung sebagai gambaran nyata yang dapat dijadikan sebagai data yang diperoleh saat observasi di TPA Wonorejo. Jenis data yang digunakan berupa data primer dan data sekunder dengan teknik analisis data observasi langsung kepada sasaran observasi dan dampak lingkungan yang terjadi yang bersifat terbuka. Hasil: Hasil observasi menunjukkan bahwa dampak timbulan sampah ini dapat menyebabkan lingkungan tanah yang tercemar yang dilihat dari indikator secara fisik pencemaran tanah yang meliputi tanah gersang dan kering. Kesimpulan: Tanah yang tertutup sampah dapat mengahasilkan gas nitrogen, asam fluida, dan zat merkuri. Selain itu pencemaran tanah dapat menyebabkan gangguan terhadap bio tanah seperti tumbuhan yang tidak bisa hidup di dalam tanah yang tercemar menimbulkan suatu makhluk hidup yang hidup di tanah yang memanfaatkan unsur hara tanah mati hal ini terjadi karena sifat kesuburan tanahnya hilang.
Comparative metabolomic profiling of Cupriavidus necator B-4383 revealed production of cupriachelin siderophores, one with activity against Cryptococcus neoformans
Authors: Ahmed Mohammed M. A. , Tripathi Siddarth K. , Boudreau Paul D. 
Published: August 2023

Cupriavidus necator H16 is known to be a rich source of linear lipopeptide siderophores when grown under iron-depleted conditions; prior literature termed these compounds cupriachelins. These small molecules bear β-hydroxyaspartate moieties that contribute to a photoreduction of iron when bound as ferric cupriachelin. Here, we present structural assignment of cupriachelins from C. necator B-4383 grown under iron limitation. The characterization of B-4383 cupriachelins is based on MS/MS fragmentation analysis, which was confirmed by 1D- and 2D-NMR for the most abundant analog (1). The cupriachelin congeners distinguish these two strains with differences in the preferred lipid tail; however, our rigorous metabolomic investigation also revealed minor analogs with changes in the peptide core, hinting at a potential mechanism by which these siderophores may reduce biologically unavailable ferric iron (4–6). Antifungal screening of the C. necator B-4383 supernatant extract and the isolated cupriachelin analog (1) revealed inhibitory activity against Cryptococcus neoformans, with IC50 values of 16.6 and 3.2 μg/mL, respectively. This antifungal activity could be explained by the critical role of the iron acquisition pathway in the growth and pathogenesis of the C. neoformans fungal pathogen.
Endovascular repair of thoracic aortic disease with isolated left vertebral artery and unfavorable proximal landing zone using fenestrated castor stent-graft
Authors: Wang Zhenhua , Fang Changcun , Song Han , Wei Duoliang , Meng Xiangbin , Bai Xiao , Liu Chunxiao , Zhao Xin 
Published: August 2023

ObjectiveThe main purpose of this study was to evaluate the safety and efficacy of Castor single-branched stent-graft combined with fenestrated technique in treatment of thoracic aortic disease (TAD) with unfavorable proximal landing area (PLZ) and isolated left vertebral artery (ILVA).MethodsFrom January 2018 to March 2022, 8 patients with TAD (6 patients with type B aortic dissections, 1 patient with type B intramural hematomas, and 1 patient with thoracic aortic aneurysm) underwent thoracic endovascular aortic repair with fenestrated Castor stent-graft due to the existence of ILVA and unfavorable PLZ. Demographic characteristics, surgical details, postoperative complications, follow-up and postoperative CTA imaging results were collected and analyzed.ResultsThe primary technical success rate was 100%. The mean operation time was 115 min (range, 70–180 min). All the left subclavian arteries (LSAs) and ILVAs of the eight patients were revascularized by fenestrated Castor stent-grafts. During the follow-up period, no deaths and complications were observed. No internal leakage, aortic rupture, retrograde type A dissection were found on computed tomography angiography. All of the LSAs and ILVAs maintained patency without stenosis.ConclusionCastor single-branched stent-graft implantation combined with fenestration technique may be safe and feasible for TAD patients with ILVA and unfavorable PLZ.
Four-section approach of fetal congenital heart disease at 11–13+6 weeks
Authors: Ling Wen , Wu Qiumei , Guo Shan , Li Shangqing , Ma Hong , Huang Biying , Zeng Liqin , Dang Tingting , Liu Min , Qiu Xiuqing , Weng Zongjie 
Published: August 2023

ObjectiveThe objective of the study is to explore the value of the four-section approach in detecting fetal heart defects in the first trimester (11–13+6 weeks), analyze the reasons for the inconsistency between the results of ultrasound examination in the first trimester and subsequent verification, and describe the most common abnormal flow patterns of four sections.Materials and methodsBetween June 2019 and June 2021, a prenatal four-section approach (upper abdominal transverse section, four-chamber section, three vessel–trachea section, and bilateral subclavian artery section) with verification results in early pregnancy was analyzed.ResultsIn total, 9,533 fetuses were included. Finally, 176 fetuses with congenital heart disease (CHD), containing 34 types, were identified. The total detection rate of cardiac abnormalities was 1.85%. 102 cases were accurately diagnosed by ultrasonography during early pregnancy. A total of 74 fetuses who had inconsistent results between fetal cardiac ultrasound and verification in early pregnancy were reported, of which the cases of 22 fetuses were inconsistent due to disease evolution and progression and the cases of 52 fetuses were inconsistent due to missed diagnosis and misdiagnosis. The sensitivity, specificity, positive predictive value, and negative predictive value of the four-section approach were 67.05%, 99.96%, 96.58%, and 99.33%, respectively. In this study, a total of 30 abnormal ultrasonic imaging patterns in four sections were summarized.ConclusionWe confirmed that the four-section approach in early pregnancy has a good diagnostic efficacy for fetal CHD. Intrauterine evolution of the fetal heart, missed diagnosis, and misdiagnosis are the reasons for the inconsistency between the results of early pregnancy ultrasound and subsequent verification. This study also presents the abnormal imaging patterns of four scan sections of CHD in early pregnancy, which are instructive for the rapid identification and diagnosis of CHD in the first trimester.
Influence and risk factors of postoperative infection after surgery for ischemic cardiomyopathy
Authors: Wen Bing , Lu Yang , Huang Xiaofan , Du Xinling , Sun Fuqiang , Xie Fei , Liu Chao , Wang Dashuai 
Published: August 2023

BackgroundStudies on postoperative infection (POI) after surgery for ischemic cardiomyopathy are still lacking. This study aimed to investigate the risk factors of POI and its influence on clinical outcomes in patients undergoing ischemic cardiomyopathy surgery.MethodsThe Surgical Treatment for Ischemic Heart Failure (STICH) trial randomized patients with ischemic cardiomyopathy [coronary artery disease (CAD) with left ventricular ejection fraction ≤35%] to surgical and medical therapy. In this study, a post hoc analysis of the STICH trial was performed to assess the risk factors and clinical outcomes of POI in those undergoing coronary artery bypass graft (CABG). Patients were divided according to whether POI developed during hospitalization or within 30 days from operation.ResultsOf the 2,136 patients randomized, 1,460 patients undergoing CABG per-protocol was included, with a POI rate of 10.2% (149/1,460). By multivariable analysis, POI was significantly related to patients' age, body mass index, depression, chronic renal insufficiency, Duke CAD Index, and mitral valve procedure. Compared to patients without POI, patients with POI had significantly longer durations of intubation, CCU/ICU and hospital stay, and higher rates of re-operation, in-hospital death and failed discharge within 30 days postoperatively. In addition, these patients had significantly higher risks of all-cause death, cardiovascular death, heart failure death, and all-cause hospitalization during long-term follow-up. However, the influence of POI on all-cause death was mainly found during the first year after operation, and the influence was not significant for patients surviving for more than 1 year.ConclusionsPOI was prevalent after surgery for ischemic cardiomyopathy and was closely related to short-term and long-term clinical outcomes, and the effect of POI mainly occurred within the first postoperative year. This study first reported and clarified the relationship between POI and long-term prognosis and the predictors for POI after surgery for ischemic cardiomyopathy worldwide, which may have certain guiding significance for clinical practice.Clinical Trial Registrationhttps://www.clinicaltrials.gov, identifier (NCT00023595).
Genetic polymorphisms are associated with individual susceptibility to dexmedetomidine
Authors: Ding Yuanyuan , Liu Aiqing , Wang Yafeng , Zhao Shuai , Huang Shiqian , Zhu Hongyu , Ma Lulin , Han Linlin , Shu Shaofang , Zheng Lidong , Chen Xiangdong 
Published: August 2023

Introduction: Dexmedetomidine (DXM) is widely used as an adjuvant to anesthesia or a sedative medicine, and differences in individual sensitivity to the drug exist. This study aimed to investigate the effect of genetic polymorphisms on these differences.Methods: A total of 112 patients undergoing hand surgery were recruited. DXM 0.5 μg/kg was administered within 10 min and then continuously injected (0.4 μg/kg/h). Narcotrend index, effective dose and onset time of sedation, MAP, and HR were measured. Forty-five single nucleotide polymorphisms (SNPs) were selected for genotype.Results: We observed individual differences in the sedation and hemodynamics induced by DXM. ABCG2 rs2231142, CYP2D6 rs16947, WBP2NL rs5758550, KATP rs141294036, KCNMB1 rs11739136, KCNMA1 rs16934182, ABCC9 rs11046209, ADRA2A rs1800544, and ADRB2 rs1042713 were shown to cause statistically significant (p &lt; 0.05) influence on the individual variation of DXM on sedation and hemodynamics. Moreover, the multiple linear regression analysis indicated sex, BMI, and ADRA2A rs1800544 are statistically related to the effective dose of DXM sedation.Discussion: The evidence suggests that the nine SNPs involved in transport proteins, metabolic enzymes, and target proteins of DXM could explain the individual variability in the sedative and hemodynamic effects of DXM. Therefore, with SNP genotyping, these results could guide personalized medication and promote clinical and surgical management.