bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the challenge of population structure brought by China’s ‘Wu Zi’ culture - Impact of economic growth and housing prices on population ageing
Authors: Chai Kuang-Cheng , Liu Rui-Yang , Zhu Jia-wei , Lan Hao-Ran , Xi Wen-Tao , Chang Ke-Chiun 
Published: December 2022

Abstract
Whether China can avoid falling into the “ageing trap” and find the main causes of the persistent ageing problem are theoretical and practical issues that need to be explored in depth. Based on inter-provincial panel data from 2006–2019, this paper uses stepwise regression to investigate whether economic growth can influence population ageing through housing prices. The study finds that: firstly, economic growth has a positive effect on population ageing. Secondly, economic growth exacerbates population ageing through the mediating effect of housing prices. Thirdly, economic growth causes regional economic disparities, resulting in a higher level of population ageing in economically developed regions than in non-economically developed regions. From the results of the study, it appears that economic growth has resulted in a larger gap between the income of people of the right age and the price of housing, accompanied by a decline in mortality rates and an increase in the burden of old age under higher levels of medical care, a disincentive to have children and an increase in the problem of ageing. It is recommended that the reform of the housing system should be deepened to facilitate the release of fertility intentions and to overcome the “ageing trap”.
JEL: F012.4, F015, F036, F016, F037
Immediate autonomic nervous system activity in skin microcirculation during osteopathic cranial vault hold intervention
Authors: Pelz Holger , Keller Micha , Müller Gero , Mathiak Klaus , Mayer Johannes , Perlitz Volker 
Published: December 2022

Abstract
Effects of osteopathy in the cranial field (OCF) frequently involve changes in skin blood flow (SBF) and autonomic nervous system (ANS) functioning. ANS related frequency markers fell short to adequately explain physiological reactions in general as well as during OCF. An intermediate (IM) frequency band generated by a brainstem pacemaker expanded ANS research in SBF. Studying IM frequencies during OCF may provide new insights on treatment relevant ANS responses. Data from forehead SBF measurements in twenty-five healthy participants were recorded in a blocked design before, during, and following an osteopathic cranial vault hold (CVH) intervention. Analyses included momentary frequencies of highest amplitude (MFHA) from wavelet time-frequency distributions and amplitudes in low (0.05 – 0.12 Hz), intermediate (0.12 – 0.18 Hz), and high (0.18 – 0.4 Hz) frequency bands. During CVH, LF averaged interval durations significantly increased, while IM and HF band durations decreased. Amplitudes significantly increased in LF, IM and HF bands. A cluster analysis found individual response patterns where 77% of the participants exhibited a highly stable, slowed LF oscillation (0.07 Hz) while another group remained in an IM dominated mode. Further explorative analyses suggested that the increase of LF activity duration during CVH may be related to higher self-regulation ability. Rhythmic patterns due to sensory input reduction and CVH in SBF matched previous findings on a central pacemaker induced ‘0.15 Hz rhythm’/IM activity, which may explain physiological reactions during CVH. These findings suggest further investigations of the role of OCF interventions in ANS mediated disorders.
Photothermia at the nanoscale induces ferroptosis via nanoparticle degradation
Authors: Fromain Alexandre , Perez Jose , de Walle Aurore Van , Lalatonne Yoann , Wilhelm Claire 
Published: December 2022

Abstract
The Fe(II)-induced ferroptotic cell death pathway has contrasted the biocompatibility of magnetic nanoparticles while offering an additional asset in cancer therapy. Nevertheless, in magnetic nanoparticles, Fe(II) is sequestered within the crystal structure, and for it to become active the nanoparticles must be degraded, a transition that is not well understood. Here, the chemical environment necessary for nanoparticle degradation and subsequent Fe(II) release is dissected. Importantly, it is evidenced that temperature acts as accelerator of the process and can be triggered remotely by laser-mediated photothermal conversion, as evidenced by the loss of the nanoparticles’ magnetic fingerprint. Remarkably, the local hot-spot temperature generated at the nanoscale could be measured in operando, in the vicinity of each nanoparticle, by comparing the laser-induced nanoparticle degradation patterns with those of global heating. Further, remote laser exposure also acts as a degradation accelerator inside cancer cells in a tumor spheroid model, with efficiency correlating with the endocytosis progression state of the nanoparticles. High-throughput imaging quantification of Fe(II) release and cell death at spheroid level confirmed the synergistic thermo-ferroptotic therapy due to the laser-induced hot-spot-mediated degradation at the nanoparticles level.
Biomarkers in neurodegeneration: A beginner’s guide into curated gene expression analyses using publicly available datasets
Authors: Jan Asad 
Published: December 2022

Abstract
The availability of bioassays for the discovery of surrogate biomarkers reflecting neuronal dysfunction in neurodegenerative diseases remains a significant challenge. With the advent of next generation sequencing technologies and refinements in genomic analyses, a substantial number of insightful datasets have recently been made available in the public domain. However, without sufficient background in programming or statistical analyses, many researchers find it a daunting task to parse such datasets. It is also likely that several researchers, especially younger researchers, are not sufficiently aware of these resources. The purpose of this brief Method/Resource article is to demonstrate the usability of publicly available datasets for probing disease relevance of candidate markers in common neurodegenerative diseases, using the microarray datasets accessible in the Gene Expression Omnibus (GEO) repository of the National Center for Biotechnology Information (NCBI). Without adopting any a priori hypothetical bias, the method presents new curated analyses, interrogating glutathione biogenesis, calcium signaling and autophagy related gene expression across the brain regions of 4 cohorts of PD patients and in a cohort of other neurodegenerative diseases. Using a step-by-step approach, the readers are familiarized with these datasets, and also guided to additional open-access online resources, with the anticipation that the method will be of great benefit to the research community in neurodegenerative diseases.
Influence of drying and pretreatment methods on certain parameters of yellow mealworm larvae (Tenebrio molitor)
Authors: Trukhanova K. A. , Mechtaeva E. V. , Novikova M. V. , Sorokoumov P. N. , Ryabukhin D. S. 
Published: December 2022

Nowadays alternative protein sources like edible insects are becoming widely used as human food. One of the most popular insect is yellow mealworm (Tenebrio molitor) due to its high nutrition value. However, pretreatment and drying are necessary to increase the food shelf life and the efficiency of its use. Due to this, the purpose of the present work was the determination of influence of pretreatment methods (freezing of larvae for 1 month, freezing for 2 hours, freezing for 1 month followed by defrosting for 2 hours at room temperature, blanching) and drying methods (convection drying at 40 °C and 60 °C, microwave drying) of yellow mealworm on its color (determination of L*, а*, b*, ΔElab, Ch, H, BI), moisture content (gravimetric method), fatty acid composition (determined by gas chromatography with mass spectroscopy) and time of drying (time required to reach constant weight). It was found that all used pretreatment and drying methods had no effect on the fatty acid composition of the larvae. In terms of drying rate and color retention, microwave drying showed better results than convection drying at 40 °C and 60 °C. Meanwhile, convection drying at 40 °C leads to the higher final moisture content of the samples. Among the pretreatment methods, only blanching the larvae samples before drying retained their color better and also accelerated the rate of the convection drying.
Estimation of wastewater flowrate in a gravitational sewer line based on a low-cost distance sensor
Authors: Tomperi Jani , Rossi Pekka M. , Ruusunen Mika 
Published: December 2022

Abstract
Wastewater flowrate exhibits valuable information on the conditions in a sewer line. However, existing hardware flowrate sensors are rather expensive, vulnerable to fouling and breakages, and require frequent and laborious maintenance. Therefore, they are typically only mounted in a few key locations of a sewer system, leading to a lack of important information in a major part of the network. Utilizing more cost-effective sensors and a soft sensor approach is advisable for estimating the flowrate at locations where hardware sensors are lacking. Here, the development and testing of a data-driven soft sensor for estimating the wastewater flowrate based on the water level information obtained from a low-cost ultrasonic distance sensor are presented. The research included a long-term functionality testing period of the sensor in a cold region. The soft sensor-based flowrate was applied to estimate inflow and infiltration, indicating the conditions of the sewer line. The harsh conditions inside the sewer manhole caused challenges for the reliability of the distance measurement based on an ultrasonic principle. With the developed model-based soft sensor, it seems possible to accurately estimate the wastewater flowrate. Together with additional information, it might also enable accurate monitoring of inflows and infiltrations.
Sugarcane bagasse ash for fipronil removal
Authors: Barbosa Larissa M. S. , Baêta Bruno E. L. , de Barros André Luis Corrêa , Almeida Marys L. Braga , Libânio Marcelo 
Published: December 2022

Abstract
Adsorbents were studied for removing fipronil, a pesticide, from water. The study included sugarcane bagasse fly ash (SBFA) and traditional activated carbon. SBFA was characterized by X-ray fluorescence, specific mass determination, electron microscopy, particle size analysis and zeta potential. The results showed that, without prior treatment, its removal efficiency for fipronil was 80% with 2 h contact time, which is much higher than reported in other studies. SBFA's zeta potential was 8.02. In low pH systems, fipronil adsorption is expected to be even more efficient, as the molecule presents both the amino group (NH) and Cl, which may favor adsorbent surface interactions by giving rise to polar electrostatic forces. The Freundlich model (R2 = 0.9290) describes the adsorption data better than the Langmuir model (R2 = 0.8870). The method developed for fipronil adsorption is low-cost and enables the reuse of sugarcane industry waste.
Using machine learning architecture to optimize and model the treatment process for saline water level analysis
Authors: Rajput Sarvesh P. S. , Webber Julian L. , Bostani Ali , Mehbodniya Abolfazl , Arumugam Mahendran , Nanjundan Preethi , Wendimagegen Adimas 
Published: December 2022

AbstractWater is a vital resource that makes it possible for human life forms to exist. The need for freshwater consumption has significantly increased in recent years. Seawater treatment facilities are less dependable and efficient. Deep learning systems have the potential to increase the efficiency as well as the accuracy of salt particle analysis in saltwater, which will benefit water treatment plant performance. This research proposed a novel method for optimization and modelling of the treatment process for saline water based on water level data analysis using machine learning (ML) techniques. Here, the optimization and modelling are carried out using molecular separation-based reverse osmosis Bayesian optimization. Then the modelled water saline particle analysis has been carried out using back propagation with Kernelized support swarm machine. Experimental analysis is carried out based on water salinity data in terms of accuracy, precision, recall, and specificity, computational cost, and Kappa coefficient. The proposed technique attained an accuracy of 92%, precision of 83%, recall of 78%, specificity of 81%, computational cost of 59%, and Kappa coefficient of 78%.
A Review on Green Synthesis and Biological Activities of Medicinally Important Nitrogen and Oxygen Containing Heterocycles
Authors: Gulati Susheel , Singh Rajvir , Sangwan Suman 
Published: December 2022

Abstract:
Recently, the application of green chemistry for the formation of potential bioactive heterocyclic moieties has turned out to be the key area of research for organic chemists due to the growing concern over environmental issues. Therefore, the development of nonhazardous synthetic protocols gained the particular attention of synthetic chemists as a frontier task in the present scenario. Nowadays, microbial infections have been haunting human civilization since prehistoric times, resulting in many deaths worldwide. Cancer is a fatal and dreadful disease without any appropriate cure, thus threatening humanity in both the developing and developed worlds. Therefore, there is a critical requirement for the design and synthesis of new classes of compounds to circumvent these diseases. Heterocycles are unique precursors for the synthesis of various pharmaceuticals and agrochemicals, particularly those possessing N- or O- moieties. The methods to prepare heterocycles are of great importance in synthesizing organic compounds, especially the heterocycles found in natural products. The synthesis of nitrogen and oxygen-containing heterocycles viz. Coumarins, dihydropyrimidinones, imidazoles, isoxazoles, and benzimidazoles represent attractive and demanding work for chemists as these molecules have found extensive applications in several fields, such as materials science, analytical chemistry and most importantly in, medicinal chemistry. In this review paper, we focus on the synthetic strategy to prepare these types of heterocyclic compounds by green methods and discuss their various biological applications.
Nanocarriers and Diabetes: New Vistas and the Way Ahead
Authors: Mishra Dinesh K. , Gautam Rupesh K. , Dixit Pankaj V. , Sharma Sanjay 
Published: December 2022

Abstract:
World Health Organization has reported an estimated 1.5 million deaths directly due to
diabetes in 2019. Center for Disease Control and Prevention, in its National Diabetes Statistics Report,
2020, says that 1 in 10 United States residents has diabetes. This rapid progression of diabetes
is noteworthy despite significant advances in the field of antidiabetic medicine. The critical challenges
in treatment are dyslipidemia, hyperinsulinemia, and hyperglycemia. The latest research has
also linked diabetes to carcinogenesis. The diabetic condition accelerates cell growth, proliferation,
migration, inflammation, angiogenesis, metastasis, and inhibition of apoptosis in cancer cells. In
addition, diabetic complications of nephropathy, retinopathy, neuropathy, cardiomyopathy, peripheral
arterial disease, coronary artery disease, and stroke increase morbidity. Amidst all these challenges,
a ray of hope is the advent of nanocarriers. The nano size helps in the targeted and controlled
delivery of drugs. In addition, nanocarrier formulation helps in the delivery of acid-labile and enzyme-
labile molecules and plant-based macromolecules via the oral route. Its use in the form of
dendrimers, ethosomes, niosomes, transfersomes, and polymeric nanoparticles is established. In
addition, different polymers used to formulate nanocarriers are also established for targeting diabetes.
Thus, this review aims to compile approaches involving the use of nanocarriers for the betterment
of pharmacotherapy of diabetes and to provide a way ahead for researchers in the field.
Protective Roles and Mechanism of Action of Plant Flavonoids against
Hepatic Impairment: Recent Developments
Authors: Boniface Pone Kamdem , Fabrice Fekam Boyom , Paumo Hugues Kamdem , Katata-Seru Lebogang Maureen 
Published: December 2022

Background:
The liver is one of the crucial organs in humans and is responsible for the
regulation of diverse processes, including metabolism, secretion, and detoxification. Ingestion of alcohol
and drugs, environmental pollutants, and irradiation are among the risk factors accountable
for oxidative stress in the liver. Plant flavonoids have the potential to protect the liver from damage
caused by a variety of chemicals.

Objective:
The present study aims to summarize up-to-date information on the protective roles of
plant flavonoids against liver damage.

Methodology:
The literature information on the hepatoprotective plant flavonoids was assessed
through various databases, which were searched from their respective inception until March 2022.

Results:
More than 70 flavonoids with hepatoprotective activity against a variety of models of liver
toxicity have been reported across the literature. Among these are flavones (19), flavonols (30),
flavanones (9), isoflavonoids (5), and biflavonoids (2). Several hepatoprotective mechanisms of action
were reported in various classes of flavonoids, including flavones and flavonols (upregulation
of the pro-survival ERK1/2 pathway; downregulation of apoptotic proteins, including Bax, Bcl-2,
Bax, BH3, caspase-3, 8, 9, etc.), flavanones (downregulation of NF-κB, TNF-α, IL-1 β, IL-6, iNOS,
etc.), isoflavonoids (downregulation of lipogenesis genes, such as SREBP-1c, LXRα, RXRα,
PPARγ and ACC2, with concomitant upregulation of genes involved in β-oxidation, including
AMPK and PPARα; inhibition of CYPs, such as CYP1A1, CYP1A2, CYP2B1, CYP2D6, CYP2E1
and CYP3A1/2).

Conclusion:
The present work demonstrated the effectiveness of plant flavonoids against hepatic
damage. However, more studies need to be performed regarding the cytotoxicity, pharmacokinetics,
and mechanisms of action of these very important cytoprotective flavonoids.
Enzyme-indole Pyrazole-capped SeNPs based Electrochemical Biosensor
for Sensitive Detection of Adenosine Triphosphate
Authors: Majola Senzekile , Sabela Myalowenkosi , Gengan Robert Moonsamy , Makhanya Talent Raymond 
Published: December 2022

Abstract:
In this study, an electrochemical biosensor for the indirect detection of Adenosine triphosphate
(ATP) was developed, which was based on the immobilization of the multiwalled carbon nanotubes
(MWCNTs) decorated with pyrazole-capped selenium nanoparticles (TRPIDC-CH3 SeNPs) and dual
enzyme reaction (hexokinase and glucose oxidase) onto the surface of a bare glassy carbon electrode
(GCE) as a working electrode. As confirmed byUltraviolet–visible spectroscopy (UV-Vis), Fourier transform
infrared (FTIR) and High-resolution electron microscope (HRTEM), the TRPIDC-CH3 SeNPs successfully
green synthesised using Allium sativum cloves and indole pyrazole ligand. The electrochemical
study of ATP was performed using cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques
on a modified electrode for indirect detection of ATP where the required strong electroactive was
[Fe(CN)6]3-/4-. The phosphate buffer solution (PBS; 0.1 M) was used as a supporting electrolyte at pH 7
containing 1 mM K4[Fe(CN)6]/K3[Fe(CN)6] as the redox probe operated at an average potential of 0.23
V. The electrochemical enzymic biosensor showed outstanding sensitivity, good stability, and satisfactory
reproducibility with an average RSD of 2.30%. The ATP was quantifiable in spiked tablets with a limit of
detection (LOD) of 0.015 mM and a limit of quantification (LOQ) of 0,050 mM.
Silymarin: A Phytoconstituent with Significant Therapeutic Potential - A Narrative Review
Authors: Kumar Pravin , Sharma Sahil , Ashawat Mahendra Singh , Pandit Vinay , Verma Chandrapal Singh , Sharma Dinesh Kumar 
Published: December 2022

Abstract:Silymarin, is a phytoactive constituent isolated from the fruits and seeds of Silybum marianum L Gaetn.), also called milk thistle belonging to the family of Asteracease. The phytoactive has been used to treat several physiological disorders. The objective of this manuscript was to review the therapeutic prospective of silymarin due to its ability to treat several physiological disorders. The databases such as Pubmed, Elsevier, and Google Scholar were reviewed for the investigations or reviews published related to the title. The discussion is focused on the immunomodulatory, chemopreventive, and anti-inflammatory mechanisms of silymarin in various metabolic and dermatological disorders. In addition, the review discusses the different therapeutic potentials of silymarin such as the management of the liver disorder, skin carcinogenesis, cardiovascular disorders, diabetes mellitus, neurodegenerative disorders, and several dermatological disorders such as melasma, anti-aging, acne, rosacea, atopic dermatitis, and psoriasis. Silymarin is safe even with a dose higher than the therapeutic dose. Silymarin had good potential for the safe and effective treatment of numerous metabolic and dermatological disorders.
COVID-19 and Brain Aging: What are the Implications of Immunosenescence?
Authors: Keller Gabriela Serafim , Medeiros Eduarda Behenck , dos Santos Maria Laura Cecconi , Lidio Adrielly Vargas , Kucharska Ewa , Budni Josiane 
Published: December 2022

Abstract:
The human lifespan is increasing, and mankind is aging. It is estimated that, until the
year 2050, this population worldwide will reach 22% of the total world population. Along with aging,
the human immunologic system changes, a process called immunosenescence or even inflammaging.
The aging immune system increases mortality and morbidity in the elderly mainly because
it loses its capacity to react against internal and external aggressions. There is a decrease in B and T
lymphocytes and CD4+ lymphocytes lose the CD28 protein expression that is needed for costimulation,
leading to reduced response to viral infections. This could be responsible for more deleterious
consequences of coronavirus disease infection in the elderly. Besides that, the human brain
ages, being more susceptible to damage and viral infections, such as COVID-19 infection. There
are several pathways that could explain the susceptibility to the COVID-19 infection in the elderly
brain, one of them is binding to ACE 2 receptors in cerebral cells through the spike protein. It has
been reported that glial cells and neurons, in addition to endothelial and arterial smooth muscle
cells in the brain, express the ACE 2 receptor, which would justify the neurological symptoms and
consequences of the disease. This infection can have several clinical manifestations such as hemorrhagic
stroke, delirium and long-term cognitive complaints, such as brain fog, polyneuropathies,
short time memory complaints and insomnia. Although none of the studies could prove that there is
a long-term neuronal damage, there are clinical sequelae that should be taken into account and
more studies are necessary to know the consequences of the infection in the elderly brain.