bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intradialytic resistance training for short daily hemodialysis patients as part of the clinical routine: a quasi-experimental study
Authors: Baião Victor M. , Duarte Marvery P. , Cunha Vinícius A. , Dourado Gustavo Í. , Leal Diogo V. , Viana João L. , Inda-Filho Antônio J. , Nóbrega Otávio T. , Ferreira Aparecido P. , Ribeiro Heitor S. 
Published: June 2023

Background and purpose: Hemodialysis patients have chronic systemic inflammation, musculoskeletal impairments, and body composition changes from several factors and exercise may attenuate. We evaluated the effects of an intradialytic resistance training program on body composition, physical function, and inflammatory markers in patients under short daily hemodialysis treatment.Materials and methods: A quasi-experimental study in clinical routine was conducted over eight months. Measures of physical function (handgrip strength, five-time sit-to-stand, timed-up and go, and gait speed), body composition (by bioelectrical impedance), and inflammatory markers (interleukin [IL]-1 beta, IL-6, IL-8, IL-10, IL-12p70, and tumor necrosis factor-α) were assessed at baseline as well as at four and eight months past continued intervention. Patients underwent two intradialytic resistance training sessions per week supervised by exercise professionals.Results: A total of 18 patients (62 ± 14 years; 55.6% ≥ 60 years; 44% female) were included. Significant increases in body mass index and basal metabolic rate were found at four and eight months compared to baseline. For physical function, timed-up and go performance improved at four and eight months compared to baseline. The other body composition and physical function measures, as well as all inflammatory markers, did not significantly change over time.Conclusion: A supervised intradialytic resistance training program for patients on short daily hemodialysis treatment, as part of the clinical routine, may induce modest changes in body mass index, basal metabolic rate, and timed-up and go performance.
Clinico-pathological initial outcome of a newly adopted novel surgical technique for nodal metastatic thyroid cancer at a large-volume centre in a high-income developing country
Authors: Hassan Iyad , Hassan Lina , Bacha Farooq , Alsalameh Mohammad , Qatee Omran , Hassan Wiam 
Published: June 2023

IntroductionThyroid cancer is the most common tumour in the endocrine system. In the past decade, the incidence of lymph node metastasis has increased, and so has the patient demand for a smaller scar. This research reports the surgical and patho-oncological short-term outcomes of a novel, minimally invasive neck dissection approach for thyroid carcinoma with lymph node metastases at the UAE's leading endocrine surgery centre.MethodsThis study employed a prospectively maintained surgical database to retrospectively analyse relevant parameters such as surgical complications, including bleeding, hypocalcaemia nerve injury and lymphatic fistula, as well as oncological metrics such as the type of tumour and the ratio of lymph node metastasis to the number of harvested lymph nodes in 100 patients that underwent open minimally invasive selective neck dissection.ResultsThe study comprised 50 patients with thyroidectomy, with bilateral central compartment neck dissection (BCCND; 50%); 34 with thyroidectomy, BCCND and selective bilateral lateral compartment neck dissection (BLCND; 34%); and 16 patients with selective unilateral central and lateral compartment neck dissection by recurrent nodal disease (ULCND; 16%). The female-to-male gender ratio was 78:22, with median ages of 36 and 42 years, respectively. Histopathology findings revealed that 92% of patients had papillary thyroid cancer (PTC) and 8% had medullary thyroid cancer. The mean total number of lymph nodes removed was 22 in the BLCND group, 17 in the ULCND group and 8 in the BCCND group (p = 0.001). Furthermore, the average lymph node metastasis was significantly higher in the BLCND group (p = 0.002). The percentage of temporary hypoparathyroidism was 29.8% and it persisted for 1.3%. The lateral compartment dissection morbidity was as follows: Four male patients with tall cell infiltrative PTC presented with pre-existing vocal cord paresis, necessitating nerve resection and anastomosis, and two more developed it after surgery (1.1% of the nerve at risk). Lymphatic fistulas occurred in four patients (4%) who were treated conservatively. Two patients were readmitted due to symptomatic neck collection. Horner syndrome was discovered in just one female patient. Male gender, aggressive histology and lateral compartment dissection independently increased surgical morbidity. In a high-volume endocrine centre, the adoption of minimally invasive selective neck dissections to treat nodal metastatic thyroid cancer did not increase specific cervical surgery complications.
Changes in Quality of Life Following SARS-CoV-2 Infection Among Jewish and Arab Populations in Israel: A Cross-Sectional Study
Authors: Elsinga Jelte , Kuodi Paul , Shibli Haneen , Gorelik Yanay , Zayyad Hiba , Wertheim Ofir , Abu Jabal Kamal , Dror Amiel , Nazzal Saleh , Glikman Daniel , Edelstein Michael 
Published: June 2023

Objectives: The long-term impact of COVID-19 on health inequalities is under-researched. We investigated changes in health-related inequalities following SARS-CoV-2 infection between the Jewish majority and the Arab/Druze minority in Israel.Methods: Patients with a positive SARS-CoV-2 RT-PCR test processed from one of the Northern-Israeli government hospitals between 03/2021 and 05/2022 were invited to participate. We collected socio-demographic, COVID-19-related, and health-related quality of life (HRQoL) information using a validated questionnaire. We compared pre- and post COVID-19 HRQoL changes between Jews and Arabs/Druze, up to 12+ months post-infection using an adjusted linear regression model.Results: Among the 881 included participants the average post-COVID HRQoL score was lower among Arabs/Druze than Jews (0.83 vs. 0.88; p = 0.005). Until 12 months post-infection, HRQoL changes were similar for Arabs/Druze and Jews. After 12 months, HRQoL dropped significantly more among Arabs/Druze than among Jews (0.11 points difference between the groups; p = 0.014), despite adjusting for socioeconomic variables.Conclusion: 12 months post-infection, COVID-19 affected the HRQoL of Arabs/Druze more than Jews, with the gap not fully explained by socio-economic differences. The COVID-19 pandemic may widen pre-existing long-term health inequalities.
UBL3 Interacts with Alpha-Synuclein in Cells and the Interaction Is Downregulated by the EGFR Pathway Inhibitor Osimertinib
Authors: Chen Bin , Hasan Md. Mahmudul , Zhang Hengsen , Zhai Qing , Waliullah A. S. M. , Ping Yashuang , Zhang Chi , Oyama Soho , Mimi Mst. Afsana , Tomochika Yuna , Nagashima Yu , Nakamura Tomohiko , Kahyo Tomoaki , Ogawa Kenji , Kaneda Daita , Yoshida Minoru , Setou Mitsutoshi 
Published: June 2023

Ubiquitin-like 3 (UBL3) acts as a post-translational modification (PTM) factor and regulates protein sorting into small extracellular vesicles (sEVs). sEVs have been reported as vectors for the pathology propagation of neurodegenerative diseases, such as α-synucleinopathies. Alpha-synuclein (α-syn) has been widely studied for its involvement in α-synucleinopathies. However, it is still unknown whether UBL3 interacts with α-syn, and is influenced by drugs or compounds. In this study, we investigated the interaction between UBL3 and α-syn, and any ensuing possible functional and pathological implications. We found that UBL3 can interact with α-syn by the Gaussia princeps based split luciferase complementation assay in cells and immunoprecipitation, while cysteine residues at its C-terminal, which are considered important as PTM factors for UBL3, were not essential for the interaction. The interaction was upregulated by 1-methyl-4-phenylpyridinium exposure. In drug screen results, the interaction was significantly downregulated by the treatment of osimertinib. These results suggest that UBL3 interacts with α-syn in cells and is significantly downregulated by epidermal growth factor receptor (EGFR) pathway inhibitor osimertinib. Therefore, the UBL3 pathway may be a new therapeutic target for α-synucleinopathies in the future.
Vulnerabilidades de las cookies en aplicaciones web: Redes Sociales y Streaming
Authors: Zambrano Rendón Aura Dolores , Cedeño-Valarezo Luis Cristóbal , Avellán Vera Diego Alexander , Herrera Molina Jahir Enrique , Cedeño Zambrano Kevin Julio 
Published: June 2023

El objetivo de esta investigación fue analizar la vulnerabilidad de los ataques relacionados con el Id de sesión y el uso de cookies en ataques Cross Site Request Forgery (CSRF) simulando un ciberataque real en un entorno controlado. La metodología empleada fue Pentesting con OWASP, se divide en cuatro fases: Reconocimiento, se enfocó en el análisis de Redes Sociales y plataformas de Streaming con el propósito de recaudar información que pueda ser utilizada para obtener acceso no autorizado al sistema o aplicación. Análisis de vulnerabilidades, se encargó de seleccionar las herramientas para explotar las vulnerabilidades identificadas. Explotación, consistió en realizar acciones para comprometer el sistema auditado utilizando herramientas automatizadas simulando un Rubber Ducky con el Arduino Raspberry Pi Pico. Post explotación, se enfocó en realizar pruebas para comprobar la información que se puede obtener al explotar las debilidades identificadas. Los resultados que se obtuvieron en base de las cookies, Facebook es la red social más vulnerable y expone la mayor cantidad de datos a los atacantes. Twitter detecta y bloquea la actividad sospechosa, mientras que LinkedIn y Reddit son las más seguras, no se pudo acceder a las cuentas utilizando las cookies extraídas. Por otro lado, YouTube es la plataforma de Streaming que brinda más información a los atacantes, mientras que Netflix es una de las más vulnerables debido a la gran cantidad de cookies encontradas.
Associations of Biomarkers of Kidney Tubule Health, Injury, and Inflammation with Left Ventricular Hypertrophy in Children with CKD
Authors: Jiang Kuan , Greenberg Jason H. , Abraham Alison , Xu Yunwen , Schelling Jeffrey R. , Feldman Harold I. , Schrauben Sarah J. , Waikar Sushrut S. , Shlipak Michael G. , Wettersten Nicholas , Coca Steven G. , Vasan Ramachandran S. , Gutierrez Orlando M. , Ix Joachim H. , Warady Bradley A. , Kimmel Paul L. , Bonventre Joseph V. , Parikh Chirag R. , Mitsnefes Mark M. , Denburg Michelle R. , Furth Susan ,   on behalf of the CKD Biomarkers Consortium
Published: June 2023

Key Points

Higher plasma and urine kidney injury molecule-1, urine monocyte chemoattractant protein-1, and lower urine alpha-1-microglobulin were associated with left ventricular hypertrophy, even after adjustment for confounders.Biomarkers of tubular injury, dysfunction, and inflammation may indicate the severity of kidney pathology and are associated with left ventricular hypertrophy.

Background
Left ventricular hypertrophy (LVH) is common in children with CKD and is associated with an increased risk of cardiovascular disease and mortality. We have shown that several plasma and urine biomarkers are associated with increased risk of CKD progression. As CKD is associated with LVH, we sought to investigate the association between the biomarkers and LVH.

Methods
In the CKD in Children Cohort Study, children aged 6 months to 16 years with an eGFR of 30–90 ml/min per 1.73 m2 were enrolled at 54 centers in the United States and Canada. We measured plasma biomarkers kidney injury molecule-1 (KIM-1), tumor necrosis factor receptor-1, tumor necrosis factor receptor-2, soluble urokinase-type plasminogen activator receptor and urine KIM-1, monocyte chemoattractant protein-1 (MCP-1), YKL-40, alpha-1-microglobulin (alpha-1m), and epidermal growth factor in stored plasma and urine collected 5 months after enrollment. Echocardiograms were performed 1 year after enrollment. We assessed the cross-sectional association between the log2 biomarker levels and LVH (left ventricular mass index greater than or equal to the 95th percentile) using a Poisson regression model, adjusted for age, sex, race, body mass index, hypertension, glomerular diagnosis, urine protein-to-creatinine ratio, and eGFR at study entry.

Results
Among the 504 children, LVH prevalence was 12% (n=59) 1 year after enrollment. In a multivariable-adjusted model, higher plasma and urine KIM-1 and urine MCP-1 concentrations were associated with a higher prevalence of LVH (plasma KIM-1 prevalence ratio [PR] per log2: 1.27, 95% confidence interval [CI], 1.02 to 1.58; urine KIM-1 PR: 1.21, 95% CI, 1.11 to 1.48; and urine MCP-1 PR: 1.18, 95% CI, 1.04 to 1.34). After multivariable adjustment for covariates, lower urine alpha-1m was also associated with a higher prevalence of LVH (PR: 0.90, 95% CI, 0.82 to 0.99).

Conclusions
Higher plasma and urine KIM-1, urine MCP-1, and lower urine alpha-1m were each associated with LVH prevalence in children with CKD. These biomarkers may better inform risk and help elucidate the pathophysiology of LVH in pediatric CKD.
Pengaruh Lingkungan Kerja Fisik Dan Pengawasan Terhadap Efektivitas Kerja Pegawai Dinas Pendidikan Kabupaten Kerinci
Authors: Pamungkas Gema Pratama 
Published: June 2023

In this study there are three variables namely physical work environment variable (X1), supervision variable (x2) and work effectiveness variable (y). The analytical tool used is descriptive analysis, multiple linear regression and coefficient of determination by using the help of statistical software version 20. The sample in this study were 52 people, namely the entire employee of the Kerinci district education office. This research is a descriptive causality study. One type of research is to present a complete picture of social settings or intended to explore clarification about social phenomena or reality by describing a number of variables. Causal research examines the causal relationship of two or more variables. the results of this study indicate that t count = 4.746 while t table with df = (n –k) = 52 - 3 is obtained t table = 2.00856 so that t count> from t table (4.746> 2.00958) or sig <α (0,000
<0,05) so that the physical work environment has a significant effect on work effectiveness. t count <t table (-0,100, <-2,008) or sig <α (0, 920 <0.05). f count> f table (11.440> 3.19) or sig <α (0.00 <0.005) so supervision does not have a significant effect on work effectiveness. the influence of the physical work environment (X1) and supervision (X2) on work effectiveness (Y) is 31.8 while the remaining 68.2% (100% -31.8) is influenced by other variables outside the research.
Peran Akuntansi Pertanggungjawaban dalam Penilaian Kinerja Pusat Biaya pada Exxonmobil Oil Indonesia Inc.
Authors: Marwan Setiawan  
Published: June 2023

ExxonMobil Oil Indonesia yang sebelumnya bernama Mobil Oil Indonesia merupakan anak perusahaan Mobil yang beroperasi di Indonesia. Exxon dan Mobil, dua perusahaan besar melakukan merger menjadi ExxonMobil. Mobil Oil Indonesia pun menjadi berubah namanya yaitu ExxonMobil Oil Indonesia Inc. Merger ini tentu saja membawa dampak bagi ExxonMobil Oil Indonesia, yaitu terjadi perubahan struktur organisasi, proses dan prosedur penyusunan anggaran, sistem pencatatan dan pelaporan biaya, pengkodean rekening, penggolongan biaya terkendali dan tak terkendali, dan laporan pertanggungjawaban yang tidak lain merupakan akuntansi pertanggungjawaban.
Penelitian ini bertujuan untuk mengetahui pelaksanaan akuntansi pertanggungjawaban dan penilaian kinerja pusat biaya pada ExxonMobil Oil Indonesia setelah merger dan sejauh mana peran akuntansi pertanggungjawaban dalam menilai kinerja pusat biaya. Metode pengumpulan data adalah observasi, wawancara dan penyebaran kuisioner. Data kuisioner dari responden diolah dengan menggunakan program SPSS 20.0 dan kemudian dilakukan analisis.
Kesimpulan yang didapat adalah akuntansi pertanggungjawaban dan penilaian kinerja pusat biaya telah dilaksanakan dengan baik oleh ExxonMobil Oil Indonesia. Akuntansi pertanggungjawaban yang telah dilaksanakan sangat membantu dalam melakukan penilaian kinerja pusat-pusat biaya.
Usama gate: A State-Preserving Circuit
Authors: Thakur Usama 
Published: June 2023

<p> This research introduces a pioneering approach in quantum computing that harnesses the fundamental principles of the Mobius strip to store and preserve the state of qubits. Leveraging the capabilities of quantum gates and entanglement, a custom quantum circuit is designed and implemented using the Qiskit framework. Through rigorous experimentation, the circuit successfully emulates the behavior of a Mobius strip, ensuring the enduring preservation of stored information. The devised methodology encompasses the creation of a quantum circuit comprising an input qubit and an output qubit. The initial state of the input qubit is determined by user input, setting the foundation for subsequent operations. By skillfully applying specialized gates and entanglement operations, the circuit faithfully represents the unique characteristics of the Mobius strip. Crucially, the output qubit’s state is measured, unveiling the resultant information encoded within. The experimental findings unequivocally establish the circuit’s unrivaled ability to steadfastly preserve information, irrespective of the number of iterations. Each execution yields the desired output, substantiating the efficacy of the bespoke gate arrangement in storing and upholding qubit states. This seminal research not only underscores the immense potential of integrating non-trivial mathematical concepts, exemplified by the Mobius strip, into quantum computing but also opens up unprecedented vistas for information storage and manipulation. The preservation of qubit states within the circuit paves the way for cutting-edge advancements in diverse quantum algorithms and applications. By seamlessly embodying the principles of scientific inquiry, this study serves as a trailblazing foundation for future explorations in the burgeoning field of quantum computing. </p>
Analisis Komunikasi Nirkabel Menggunakan IoT Network Protocols pada Stasiun Cuaca Mini
Authors: Burhani Muhammad Ulum , Novianto Dwi , Yuliantari Risky Via 
Published: June 2023

Pengaruh cuaca sangat berpengaruh terhadap berbagai kegiatan manusia seperti pada sektor pertanian, kesehatan, transportasi. Informasi tentang iklim berpengaruh untuk menentukan pola tanam, penyiraman, pemetaan agroekologi. Pengembangan sistem mini weather station secara nirkabel dapat menjadi solusi dalam pembacaan parameter cuaca dalam wilayah tertentu. Dalam perkembangannya komunikasi nirkabel menggunakan jaringan internet disebut dengan IoT (Internet of Things) dengan beberapa protokol diantaranya adalah CoAP (Constrained Application Protocol), HTTP (Hypertext Transfer Protocol ), dan MQTT (Message Queuing Telemetry Transport). Tujuan dari penelitian ini adalah menganalisis QoS (Quality of Service) dari protokol komunikasi yang digunakan pada stasiun cuaca mini dengan parameter sensor arah mata angin, sensor intensitas cahaya, sensor tekanan undara, sensor kecepatan angin, sensor curah hujan, sensor suhu, sensor kelembaban. Berdasarkan penelitian yang telah dilakukan diperoleh rerata nilai error dari sensor yang digunakaan adalah 5,69% dengan 3,06% error pada sensor intensitas cahaya;12,5% error pada sensor arah angin; 0,88% error pada sensor tekanan udara; 10,33% error pada sensor kecepatan angin; 6,5% error pada sensor curah hujan; 1,7% error pada sensor suhu dan 4,9% pada sensor kelembaban. Metode pengukuran QoS digunakan untuk mengidentifikasi kualitas pengiriman protokol yang digunakan sehingga memperoleh data throughput sebesar 463,01 bps (bit per secon) dengan kategori sangat baik, delay sebesar 48,767 ms dengan kategori sangat baik, packet loss sebesar 0,0015% dengan kategori sangat baik, serta jitter sebesar 0,02ms dengan kategori baik.
Kajian Implementasi Program Corporate Social Responsibility (CSR) Oleh Perusahaan Pertambangan (Studi Kasus PT.Antam Tbk)
Authors: Dara Kospa Herda Sabriyah 
Published: June 2023

Corporate Sosial Responsibility (CSR) itu sendiri merupakan suatu bentuk tanggung jawab sosial yang harus dilaksanakan oleh sebuah perusahaan terhadap daerah dan masyarakat sekitar perusahaan yang terkena dampak dari aktivitas perusahaan, baik secara langsung maupun tidak langsung Pihak perusahaan dituntut memiliki kepedulian terhadap masyarakat dengan mengedepankan kepentingan jangka panjang dan keberlanjutan daripada kepentingan kepentingan sesaat melalui program CSR. Corporate Social Responsibility (CSR) bukan lagi sekadar kewajiban perusahaan, tetapi menjadi sebuah strategi yang dikembangkan oleh perusahaan. Implementasi CSR yang dilakukan PT Antam Tbk terdiri dari tiga bentuk, yaitu Program Pengembangan Kemasyarakatan, Program Kemitraan dan Program Bina Lingkungan. Semua desa yang ada di sekitar PT Antam Tbk menerima ketiga program tersebut, antara lain berbentuk pembangunan infrastruktur desa, pengembangan pendidikan, perbaikan kesehatan, bantuan modal, dan pelatihan untuk pengembangan usaha.. Selain itu, ada ketiga program yang ditangani oleh PT Antam yang bermuatan pengembangan masyarakat, yaitu : pengembangan program kemitraan (PK), Bina Lingkungan (BL), dan pengembangan masyarakat, disambut positif oleh masyarakat. Masyarakat berharap bantuan ini akan diperbesar dari tahun ke tahun. Diharapkan perusahaan-perusahaan yang melakukan CSR mempertahankan dan meningkatkan kepeduliannya pada lingkungan dan masyarakat agar tercipta lingkungan yang bersih dan masyarakat yang lebih baik, Kedua, upayakan program CSR dapat membangun kemandirian masyarakat dan sustainable (berlanjut) hingga saat PT Antam TbkÂ tidak beroperasi kembali di wilayah tersebut dan Ketiga, bagi semua perusahaan untuk tidak menganggap CSR sebagai kegiatan menghambur-hamburkan uang, tapi dijadikan sarana investasi. Kegiatan CSR tersebut harus dirancang dengan baik dan penuh perencanaan, bukan semata-mata hanya untuk menjaga eksistensi sebuah perusahaan, sehingga program dapat tepat sasaran dan masyarakat mendapat manfaat secara penuh dari adanya program-program CSR tersebut.Kata Kunci : CSR, Pemberdayaan Masyarakat, Keberlanjutan