bluuebunny/crossref_metadata_2025_split huggingface dataset:
Procesos de acompañamiento socioeducativo y adaptación a la vida en libertad en mujeres penadas
Authors: Burgos Jiménez Rubén , Amaro Agudo Ana , Añaños Fanny 
Published: January 2023

Desde el campo educativo, el medio penitenciario puede constituir un espacio institucional orientado a la acción socioeducativa para la reeducación e in-reinserción de las personas penadas. El acompañamiento profesional supone un proceso de actuación que fomenta, entre otras, la autonomía y el empoderamiento para la vida en libertad. Esto es desarrollado por distintos profesionales o personal vinculado al medio, distinguiéndose las actuaciones intrapenitenciarias y extrapenitenciarias. Sin embargo, las mujeres penadas experimentan desigualdades institucionales debido a su baja presencia poblacional, características personales específicas, etc., limitando su acompañamiento profesional e in-reinserción. El presente artículo analiza las percepciones de los profesionales penitenciarios y mujeres penadas sobre los procesos de acompañamiento realizados y la adecuación a sus características sociopersonales para la mejor in-reinserción. Se realizó una investigación nacional con una muestra de 756 mujeres penadas y 109 profesionales penitenciarios en el marco de dos proyectos I+D+i. Se aplicaron cuestionarios mixtos a ambos tipos de muestra y entrevistas semiestructuradas a mujeres. Para los datos cuantitativos se realizó un análisis estadístico descriptivo bivariado y para los cualitativos un análisis de contenido. Los resultados mostraron que los procesos de acompañamiento son desarrollados en su mayoría por profesionales extrapenitenciarios en régimen ordinario (84.6%), siendo los que más consideran las necesidades sociopersonales de las mujeres, especialmente los niveles educativos y las drogodependencias. Las mujeres penadas presentaron dificultades para la continuidad de los procesos de acompañamiento en régimen abierto, ya que estas acciones son recibidas solo por el 51.6%, destacando las mujeres adictas (58.3%) y víctimas de violencia de género (63.6%). Asimismo, el 38.7% demandó programas de inserción sociolaboral y el 31.2% intervenciones individualizadas. Con todo, se evidenciaron limitaciones en la acción socioeducativa con perspectiva de género y alcance de las acciones de acompañamiento profesional en régimen abierto, lo que impide una adecuada adaptación de las mujeres a la vida en libertad.
Epidemiological Insights on Medication Concurrency and Polypharmacy in People With Multiple Sclerosis in Greece
Authors: Bakirtzis Christos , Nikolaidis Ioannis , Boziki Marina-Kleopatra , Grigoriadou Eleni , Karakasi Maria-Valeria , Moysiadis Theodoros , Kesidou Evangelia , Papazisis Georgios , Grigoriadis Nikolaos 
Published: January 2023

ABSTRACT

BACKGROUND
Besides disease-modifying therapies, various pharmacologic agents are frequently prescribed to people with multiple sclerosis (MS) for symptom treatment and for comorbid conditions. The present study aims to investigate the types and frequencies of agents prescribed to people with MS in Greece using records from the nationwide digital prescription database.

METHODS
Prescription records for 21,218 people (65.9% women) with MS were included in the study. The criterion for study inclusion was a minimum of 3 months of continuous prescription of an agent. Identified treatments were further examined by age group.

RESULTS
Antispasticity agents (17.5%) and fampridine (14.5%) were the most regularly prescribed symptomatic medications. Antihypertensives (21.1%) and drugs for affective disorders, including antidepressants (36.1%) and anxiolytics (16.2%), were the most frequently prescribed medications for comorbid conditions. Antidepressants were prescribed at almost equally high rates among individuals older than 40 years. Hypertension was one of the leading comorbidities among the study sample, with rates rising significantly after age 40 years and plateauing after age 60 years. Polypharmacy was observed in 22.5% of the study sample, with a higher incidence among people with MS older than 60 years (46.98%).

CONCLUSIONS
Agents prescribed for the treatment of disease symptoms and other medical conditions are expected to positively affect quality of life in people with MS. However, polypharmacy seems to be particularly high, especially in the aged population. The potential implications of polypharmacy in the disease course should further be explored.
A cross-sectional survey of avian influenza knowledge among poultry farmworkers in Indonesia
Authors: Rehman Saifur , Shehzad Aamir , Andriyani Lisa Dyah , Effendi Mustofa Helmi , Abadeen Zain Ul , Ilyas Khan Muhammad , Bilal Muhammad 
Published: January 2023

Background
Avian influenza (AI) poses a serious threat to global public health, especially the highly pathogenic form. Awareness and protective behavior among the public, particularly the high-risk populations, are essential for prevention and control. This study aimed to ascertain the level of AI knowledge among Indonesia’s poultry farmworkers.

Methods
This was a cross-sectional study conducted online. A predesigned standardized questionnaire, containing six demographic questions and 14 questions on AI knowledge, was used. The questionnaire was distributed via WhatsApp and email platforms. Volunteers (respondents) included 119 men and 81 women, aged 18–50 years, who work on poultry farms in Indonesia. Data were analyzed using the chi-squared and Fisher exact tests.

Results
The study’s findings revealed that more than two-thirds (67.0%) of the respondents had heard about AI. Their primary sources of information were health workers (36.0%) and media, especially television (34.0%). The majority of the participants (91.3%) had good knowledge about AI as a contagious infection, transmissible from birds to other birds, animals, or humans. A total of 76.8% of the respondents believed that poultry workers and veterinarians were at high risk of contracting AI infection.

Conclusions
The study concluded that poultry workers had good knowledge about AI infection, transmission, and risk variables. Health workers and television were the main sources of information on AI. The level of AI knowledge was high among the respondents.
Transcription analyses of differentially expressed mRNAs, lncRNAs, circRNAs, and miRNAs in the growth plate of rats with glucocorticoid-induced growth retardation
Authors: Yin Mingyue , Wang Junqi , Zhang Juanjuan , Wang Wei , Lu Wenli , Xu Fei , Ma Xiaoyu , Lyu Sheng , Chen Lifen , Zhang Lidan , Dong Zhiya , Xiao Yuan 
Published: January 2023

Background
Glucocorticoids (GCs) are commonly used to treat autoimmune diseases and malignancies in children and adolescents. Growth retardation is a common adverse effect of GC treatment in pediatric patients. Accumulating evidence indicates that non-coding RNAs (ncRNAs) are involved in the pathogenesis of glucocorticoid-induced growth retardation (GIGR), but the roles of specific ncRNAs in growth remain largely unknown.

Methods
In this study, 2-week-old male Sprague-Dawley rats had been treated with 2 mg/kg/d of dexamethasone for 7 or 14 days, after which the growth plate tissues were collected for high-throughput RNA sequencing to identify differentially expressed mRNAs, lncRNAs, circRNAs, and miRNAs in GIGR rats.

Results
Transcriptomic analysis identified 1,718 mRNAs, 896 lncRNAs, 60 circRNAs, and 72 miRNAs with different expression levels in the 7d group. In the 14d group, 1,515 mRNAs, 880 lncRNAs, 46 circRNAs, and 55 miRNAs with differential expression were identified. Four mRNAs and four miRNAs that may be closely associated with the development of GIGR were further validated by real-time quantitative fluorescence PCR. Function enrichment analysis indicated that the PI3K-Akt signaling pathway, NF-kappa B signaling pathway, and TGF-β signaling pathway participated in the development of the GIGR. Moreover, the constructed ceRNA networks suggested that several miRNAs (including miR-140-3p and miR-127-3p) might play an important role in the pathogenesis of GIGR.

Conclusions
These results provide new insights and important clues for exploring the molecular mechanisms underlying GIGR.
Inter-rater and intra-rater reliability of isotonic exercise monitoring device for measuring active knee extension
Authors: Limsakul Chonnanid , Sengchuai Kiattisak , Duangsoithong Rakkrit , Jindapetch Nattha , Jaruenpunyasak Jermphiphut 
Published: January 2023

Background
The goal of this study was to assess the reliability of electromyography and range of motion measurements obtained using a knee exercise monitoring system. This device was developed to collect data on knee exercise activities.

Methods
Twenty healthy individuals performed isotonic quadriceps exercises in this study. The vastus medialis surface electromyography (sEMG) and range of motion (ROM) of the knee were recorded during the exercise using the isotonic knee exercise monitoring device, the Mobi6-6b, and a video camera system. Each subject underwent a second measuring session at least 24 h after the first session. To determine reliability, the intraclass correlation coefficients (ICCs) and standard error of measurement (SEM) at the 95% confidence interval were calculated, and a Bland–Altman analysis was performed.

Results
For inter-rater reliability, the ICCs of the mean absolute value (MAV) and root mean square (RMS) of sEMG were 0.73 (0.49, 0.86) and 0.79 (0.61, 0.89), respectively. ROM had an ICC of 0.93 (0.02, 0.98). The intra-rater reliability of the MAV of the sEMG was 0.89 (0.71, 0.96) and the intra-rater reliability of RMS of the sEMG was 0.88 (0.70, 0.95). The ROM between days had an intra-rater reliability of 0.82 (0.54, 0.93). The Bland–Altman analysis demonstrated no systematic bias in the MAV and RMS of sEMG, but revealed a small, systematic bias in ROM (−0.8311 degrees).

Conclusion
For sEMG and range of motion measures, the isotonic knee exercise monitoring equipment revealed moderate to excellent inter- and intra-rater agreement. However, the confidence interval of ROM inter-rater reliability was quite large, indicating a small agreement bias; hence, the isotonic knee exercise monitor may not be suitable for measuring ROM. This isotonic knee exercise monitor could detect and collect information on a patient’s exercise activity for the benefit of healthcare providers.
Lead Ion Sorption Capacity and the Structural Properties of the Humic Acid Extracts from Evergreen Forests of Different Agro-ecological Zones of Kerala Western Ghats
Authors: Ninu J. M. , Sandeep S. 
Published: January 2023

Forest soils are enriched with soil carbon content. The vegetation and precipitation influences it’s chemical structure. The chemical structure directly contributed to its entire properties. Physico-chemical properties play vital role in its soil functioning. The sorption capacity of the humic acid can be applied in the nutrient uptake enhancement and waste water treatment. The study was conducted in the humic acid extract of evergreen forest of different agro-ecological zones of Kerala. Extraction was done by the acidic precipitation method recommended by International Humic Substance Society (IHSS). Determine the chemical structural variations and properties of the humic acid extracts followed by determining the sorption capacity of the material with lead ion. The study revealed the higher percentage of adsorption of lead ion with humic acid extract from evergreen forest of northern high hills –charnockite zone of western ghats of Kerala. This was the combined effect of enhanced cation exchange capacity and –COOH acidity of the material. These chemical structure and the functional properties to the sorption capacity of the humic acid extract to chelate the lead ion was evaluated .The higher cation exchange capacity and the –COOH acidity favoured the lead ion adsorption. Adsorption isotherm modeling was revealed the multilayer and monolayer adsorption of lead ion on humic acid depends with the heterogeneity of the HA surfaces. Maximum amount of lead ion molecule adsorbed on the HA surface was observed for humic acid from SHH-K agro-ecological zone. This method can be considered as economically viable green method for looking forward technology for waste water treatment.
The Effect of Work Environment and Work-life Balance on Job Satisfaction: Work Stress as a Mediator
Authors: Jessica Nathania , Afifah Nur , Daud Ilzar , Sulistiowati . , Pebrianti Wenny 
Published: January 2023

Aims: Employees are one of the crucial factors in a company. Company must be able to pay attention to the physical and mental needs of the employee to obtain good performance. Work environment and work-life balance are the factors that affect the employees’ performance and job satisfaction. This research aims to identify the effect of the work environment and work-life balance on the job satisfaction of the employee’s millennial generation which is mediated by stress.
Study Design: Explanatory Research.
Place and Duration of Study: millennials and have worked in Indonesia, between October 2022 and November 2022.
Methodology: The method of collecting the data is by using a questionnaire through a purposive sampling technique. The use of Structural Equation Modelling (SEM) with the tool of AMOS 26. Sample: We included 206 respondents (80 men, 126 women; age range 20-35 years).
Results: The result of this research indicates that the work environment and work-life balance have a negative and significant effect on work stress but a positive and significant effect on job satisfaction. Meanwhile, work stress has a negative and significant positive relation to job satisfaction when mediated by work stress.
Conclusion: This research reveals that work stress has a direct or indirect relationship to one's job satisfaction. Based on the research that has been done, it is known that the work environment and work-life balance are several factors that make workers feel satisfied with their jobs. They will experience work stress, where job stress is a mediator that will indirectly affect one's job satisfaction.
Cell Development Enhanced Bionic Silk Hydrogel on Remodeling Immune Pathogenesis of Spinal Cord Injury via M2 Polarization of Microglial
Authors: Ling Jue , Huang Tingting , Wu Ronghua , Ma Chao , Lin Ge , Zhou Zhihao , Wang Junpei , Tu Qifeng , Tang Xiaoxuan , Liu Yan , Liu Mei , Yang Liu , Yang Yumin 
Published: January 2023

AbstractDue to the complex spatial‐temporal pathophysiology of spinal cord injury (SCI), effective modulation of SCI‐specific inflammatory pathogenesis to achieve desirable therapeutic effects on functional recovery still remains challenging. Herein, cell‐enhanced photocrosslinked silk fibroin hydrogels with extracellular matrix‐mimicking cues of mechanical properties and RGD (Arg‐Gly‐Asp) signals are gelled in situ to fill the lesion site to modulate injury‐induced neuroinflammation and promote neurite regrowth after SCI. The bionic hydrogel system provides biomimetic mechanical cues to promote neuronal differentiation of neural stem/progenitor cells (NPCs) and neurite growth by activating YAP nuclear expression. Importantly, favored by the strong capacity of silk fibroin hydrogels on macrophage/microglia recruitment, NPCs encapsulated hydrogel (NPCs@SFRGD0.1) effectively promotes recruited macrophages/microglia to M2 polarization in the lesion site by releasing S100A4 and thereby remodels the inflammatory microenvironment after SCI. Moreover, NPCs@SFRGD0.1 successfully reduces glial scar formation and accelerates corticospinal tract axon regrowth to improve locomotor recovery. Overall, this work contributes to illustrating the therapeutic mechanism of NPCs development based biomaterial therapies on modulating inflammatory microenvironment and this NPCs enhanced silk fibroin hydrogel provides a promising therapeutic strategy for SCI.
Recent Progress on the Development of Magnetically‐Responsive Micropillars: Actuation, Fabrication, and Applications
Authors: Ni Ke , Wang Zhengzhi 
Published: January 2023

AbstractStimuli‐responsive micro‐pillared structures can perform complex and precise tasks at the microscale through dynamic and reversible deformation of the pillars in response to external triggers. Magnetic field is one of the most common actuation strategies due to its incomparable advantages such as instantaneous response, remote and nondestructive control, and superior biocompatibility. Over the past decade, many researches are attempted to design and optimize magnetically‐responsive micropillars for a wide range of applications and great progresses are accomplished. In this review, the most important aspects of recent progress of magnetically‐responsive micropillars are covered to give a comprehensive and systematical introduction to this new field, from the actuation mechanisms, fabrication methods, and deformation patterns to the practical applications. The increasingly maturing fabrication techniques can provide low‐cost and large‐scale magnetic micropillars with homogeneous responses. Some advanced techniques are developed to fabricate micropillars with programmable and reprogrammable responses for site‐specific and reconfigurable actuations. On the other hand, practical applications for particle/droplet/light manipulation, flow generation, miniature swimming/climbing/carrying microrobots, tunable adhesion, cellular probe, fog collector, and anti‐ice surfaces are also summarized. Finally, current challenges that limit the industrial implementation are discussed and the authors’ perspectives on the future directions of magnetically‐responsive micropillars are stated.
Cell‐Sized Lipid Vesicles as Artificial Antigen‐Presenting Cells for Antigen‐Specific T Cell Activation
Authors: Chen Jui‐Yi , Agrawal Sudhanshu , Yi Hsiu‐Ping , Vallejo Derek , Agrawal Anshu , Lee Abraham P. 
Published: January 2023

AbstractIn this study, efficient T cell activation is demonstrated using cell‐sized artificial antigen‐presenting cells (aAPCs) with protein‐conjugated bilayer lipid membranes that mimic biological cell membranes. The highly uniform aAPCs are generated by a facile method based on standard droplet microfluidic devices. These aAPCs are able to activate the T cells in peripheral blood mononuclear cells, showing a 28‐fold increase in interferon gamma (IFNγ) secretion, a 233‐fold increase in antigen‐specific CD8 T cells expansion, and a 16‐fold increase of CD4 T cell expansion. The aAPCs do not require repetitive boosting or additional stimulants and can function at a relatively low aAPC‐to‐T cell ratio (1:17). The research presents strong evidence that the surface fluidity and size of the aAPCs are critical to the effective formation of immune synapses essential for T cell activation. The findings demonstrate that the microfluidic‐generated aAPCs can be instrumental in investigating the physiological conditions and mechanisms for T cell activation. Finally, this method demonstrates the feasibility of customizable aAPCs for a cost‐effective off‐the‐shelf approach to immunotherapy.
Nuclear Fructose‐1,6‐Bisphosphate Inhibits Tumor Growth and Sensitizes Chemotherapy by Targeting HMGB1
Authors: Li Yeyi , Fu Yuan , Zhang Yan , Duan Bilian , Zhao Yanli , Shang Man , Cheng Ying , Zhang Kai , Yu Qiujing , Wang Ting 
Published: January 2023

AbstractMetabolites are important for cell fate determination. Fructose‐1,6‐bisphosphate (F1,6P) is the rate‐limiting product in glycolysis and the rate‐limiting substrate in gluconeogenesis. Here, it is discovered that the nuclear‐accumulated F1,6P impairs cancer cell viability by directly binding to high mobility group box 1 (HMGB1), the most abundant non‐histone chromosome structural protein with paradoxical roles in tumor development. F1,6P disrupts the association between the HMGB1 A‐box and C‐tail by targeting K43/K44 residues, inhibits HMGB1 oligomerization, and stabilizes P53 protein by increasing P53–HMGB1 interaction. Moreover, F1,6P lowers the affinity of HMGB1 for DNA and DNA adducts, which sensitizes cancer cells to chemotherapeutic drug(s)‐induced DNA replication stress and DNA damage. Concordantly, F1,6P resensitizes cancer cells with chemotherapy resistance, impairs tumor growth and enhances chemosensitivity in mice, and impedes the growth of human tumor organoids. These findings reveal a novel role for nuclear‐accumulated F1,6P and underscore the potential utility of F1,6P as a drug for cancer therapy.
Changes in self‐ and study partner–perceived cognitive functioning in relation to amyloid status and future clinical progression: Findings from the SCIENCe project
Authors: Dubbelman Mark A. , Sikkes Sietske A. M. , Ebenau Jarith L. , van Leeuwenstijn Mardou S. S. A. , Kroeze Lior A. , Trieu Calvin , van Berckel Bart N. M. , Teunissen Charlotte E. , van Harten Argonde C. , van der Flier Wiesje M. 
Published: January 2023

AbstractIntroductionWe investigated changes in self‐ and study partner–reported self‐perceived cognitive decline in relation to amyloid pathology and clinical progression, in a sample of cognitively normal individuals.MethodsA total of 404 participants (63 ± 9 years, 44% female) and their study partners completed the Cognitive Change Index (CCI) yearly (0.7–6.8 follow‐up years; n visits = 1436). Baseline and longitudinal associations between (change in) CCI scores, amyloid, and clinical progression were modeled in linear mixed models and Cox regressions.ResultsCCI–study partner scores of amyloid‐positive individuals increased over time (B = 1.79, 95% confidence interval [CI] = [0.51, 3.06]), while CCI–self scores remained stable (B = −0.45, 95% CI = [−1.77, 0.87]). Ten‐point higher baseline CCI–study partner (hazard ratio [HR] = 1.75, 95% CI = [1.30, 2.36]) and CCI–self scores (HR = 1.90, 95% CI = [1.40, 2.58]) were associated with an approximately 2‐fold increased risk of progression to mild cognitive impairment or dementia.DiscussionStudy partner–reported but not self‐perceived complaints increase over time in amyloid‐positive individuals, supporting the value of longitudinal study partner report, even in initially cognitively normal individuals.