bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract B023: The impact of the promotoras program on knowledge, attitudes, and cervical cancer screening among Hispanic/Latina women: Rapid review
Authors: Gareis Christina E. , Hunter Paul , Leader Amy 
Published: January 2023

Abstract
Cancer is one of the leading causes of death among Hispanics/Latinos adults. Within the Hispanic/Latino population, women have higher rates of infection-related cancers, such as cervical cancer, compared to other racial and ethnic minorities. Women who have a poor education, low socioeconomic status, and do not speak English have a greater incidence of cervical cancer. However, promotoras, who are health promoters, have been shown to be an effective public health intervention because they provide education, address barriers, and increase access to preventive care services. This rapid review identified and examined studies from PubMed and Scopus on the impact that promotoras had on Hispanic/Latina women regarding knowledge, attitudes, and cervical cancer screening uptake. Out of the 490 articles that met the search criteria, 14 met the inclusion criteria. Studies included various types of promotora interventions, varied in sample size, design, location, and in length of study. Several studies suggested that promotoras are effective in increasing knowledge and awareness of cervical cancer, Pap tests, and human papilloma virus (HPV). Additionally, promotoras are effective in positively changing attitudes, increasing self-efficacy, and perceived benefits of routine Pap test screening. Lastly, the promotoras demonstrate that they can change cancer screening behaviors and address financial and capacity barriers of cervical cancer screening. While most studies reported findings, a few studies showed no change in outcomes or mixed results. Overall, promotoras have a positive impact in overcoming challenges to cervical cancer screening in Hispanic/Latino communities.
Citation Format: Christina E. Gareis, Paul Hunter, Amy Leader. The impact of the promotoras program on knowledge, attitudes, and cervical cancer screening among Hispanic/Latina women: Rapid review [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B023.
Abstract B033: Increasing sexual transmitted diseases and promoting condom use among youth: Evaluation of year 2 data from the Proud Teens of Philly (PTOP) program
Authors: Truehart Jade A. , Merceir Ra'Ann , Bhimla Aisha , Tan Yin , Liao Sabrina , Wang Min Qi , Sileo Jane , Allen Maya , Ma Grace X. 
Published: January 2023

Abstract
Background: Rates of sexually transmitted disease (STD) and teen pregnancy are much higher in Philadelphia than the national average. Proud Teens of Philly (PTOP) is a sexual health program aimed at reducing the high teen birth rate and STD cases in Philadelphia. The program provides sexual health education to high-risk youth ages 12-19 in the Greater Philadelphia area. The materials used to implement the PTOP program, “Making Proud Choices”, is an evidence-based curriculum that was reviewed and tailored for its cultural and age appropriateness, and medical accuracy. Methods: During the second year of the program, PTOP was implemented virtually and in-person to 411 youth in Philadelphia schools and community-based organizations. Community-based participatory research (CBPR) strategies and systems thinking approach were used in site and participant recruitment, program implementation, and evaluation. The educational content consisted of 8 modules of the “Making Proud Choices” curriculum. Pre and post surveys were administered to participants at the first and last implementation sessions, respectively. During Year 2, 391 pre-surveys and 208 post-surveys were collected. Results: There were significant increases in knowledge about fluids that transmit HIV (pre=23.47 post=25.07 t=4.65 p=&lt;.0001), behaviors that transmit HIV (pre=10.86 post= 19.05 t=9.37 p=&lt;.0001), condoms preventing pregnancy (pre=59.57 post=76.41 t=2.8 p=0.0057) and condoms preventing HIV (pre=46.29 post=68.92 t=2.98 p=0.0035). There was also significant increase in knowledge about affirmative consent before sexual behaviors (pre=20.05 post= 0.42 t=3.71 p=0.0003) and preparedness to use condoms (pre=39.34 post=59.19 t=2.43 p=0.0169) Conclusion: PTOP, a sexual health program was effective in increasing knowledge of STD and condom use among high-risk teens in Philadelphia. We will discuss the use of CBPR strategies and systems thinking in the design and implementation of this program.
Citation Format: Jade A. Truehart, Ra'Ann Merceir, Aisha Bhimla, Yin Tan, Sabrina Liao, Min Qi Wang, Jane Sileo, Maya Allen, Grace X. Ma. Increasing sexual transmitted diseases and promoting condom use among youth: Evaluation of year 2 data from the Proud Teens of Philly (PTOP) program [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B033.
Abstract B099: Localized implicit and explicit forms of anti-gay prejudice and area-specific chronic disease prevalence
Authors: Garrido Carlos O. 
Published: January 2023

Abstract
Objectives. Ample evidence suggests that prejudice detrimentally affects individual-level health status, but little is known about associations between anti-gay/lesbian prejudice and prevalence for stress-modulated chronic diseases. Moreover, research examining implicit or “automatic” and explicit or “overt” prejudice in relation to the health status of sexual minorities and non-minorities remain scant. Thus, I examined the influence of dual forms of prejudice on chronic disease disparities among gay male and lesbians in relation to straight-identifying individuals. Methods. Using the Behavioral Risk Factor Surveillance System (BRFSS) survey responses collected in 2020 and localized measures of anti-gay prejudice from an online forum, I examined the association between geographic area-specific levels of implicit and explicit anti-gay/lesbian prejudice and prevalence for the following stress-modulated chronic conditions: heart disease, diabetes, stroke, and cancer. The sample included gay/lesbian and straight male and female adults living in 28 U.S. states. Results. Relative to areas with low prejudice, residents living in areas high in prejudice (both forms) reported higher prevalence for diabetes and COPD among sexual minorities. Both forms of prejudice predicted greater number of reported days of poor physical and mental health for gay male and lesbian residents. Among heterosexual residents, implicit prejudice predicted greater prevalence for all diseases and explicit prejudice predicted prevalence for all diseases but cancer. Conclusions. Findings show that both forms of anti-gay prejudice predict chronic disease diagnoses for gay/lesbian and straight residents. Theoretical insight using the minority-stress model and practical implications are discussed.
Citation Format: Carlos O. Garrido. Localized implicit and explicit forms of anti-gay prejudice and area-specific chronic disease prevalence [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B099.
Abstract B112: Overall satisfaction with cancer care in a lesbian, gay, bisexual, transgender, queer and intersex population
Authors: Burnett Colin , Jesdale William 
Published: January 2023

Abstract
Background: Lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI+) people living with cancer have unique health considerations that must be assessed to provide high quality, individualized patient care. LGBTQI+ health education materials may play a pivotal role in cancer survivors’ (“persons on a cancer journey”) experiences throughout their cancer care continuum. Methods: We identified 2,500 LGBTQI+ persons on a cancer journey who completed the “OUT: National Cancer Survey,” conducted by the National LGBT Cancer Network in 2020-2021, and classified participants by their self-reported level of satisfaction with their overall cancer care. We examined care satisfaction in relation to patient access to LGBTQI+-tailored health education resources and the influence of gender identity and/or sexual orientation on survivors’ experiences before, during, and after cancer treatment. Results: Most persons on a cancer journey reported lacking access to vital health education resources specific to their LGBTQI+ identities in areas of mental health (70%), physical activity (91%), tobacco cessation (89%), and alcohol consumption (86%), regardless of their satisfaction with overall care. Further, the majority of participants believe it would be valuable to receive tailored LGBTQI+ education materials specifically in areas of mental health (80%) and physical activity (67%), while also incorporating information specific to LGBTQI+ individuals into their post-treatment care plans (74%). Conclusion: LGBTQI+ persons on a cancer journey value information and health education materials that are tailored. Increased access to such materials may have large implications for the satisfaction of LGBTQI+ cancer persons on a cnacer journey with their overall cancer care.
Citation Format: Colin Burnett, William Jesdale. Overall satisfaction with cancer care in a lesbian, gay, bisexual, transgender, queer and intersex population [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr B112.
Abstract C021: Fucoxanthin anti-tumor effects on the proliferation, angiogenesis, apoptosis, and migration of triple-negative breast cancer cells
Authors: Ahmed Shade' , Mendonca Patricia , Messeha Samia , Badisa Ramesh , Soliman Karam F. 
Published: January 2023

Abstract
Breast cancer is the most commonly occurring cancer in women worldwide and is the second most common cancer among women in the United States. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer and accounts for about 10-15% of all breast cancers. TNBC is mainly found in Caucasian and African American women. The tumor microenvironment promotes tumor initiation and progression, preceding invasive metastasis, increased cell growth, and angiogenesis. Therefore, the inhibition of these processes may reduce breast cancer development. Several dietary natural products show the ability to ameliorate the aggressiveness of breast cancer, leading to the inhibition of proliferation and angiogenesis, induction of apoptosis, and reduction of breast cancer progression and tumor development. PURPOSE: In the current study, the pharmacological effect of the natural compound fucoxanthin, a xanthophyll subset of carotenoids in brown macroalgae, is investigated in genetically different MDA-MB-231 (Caucasian) and MDA-MB-468 (African American) TNBC cell lines. METHODS: Cytotoxic and cell growth assays, angiogenic arrays, RT-PCR, apoptotic, and migration assays were performed. RESULTS: Fucoxanthin (1.56 - 300 µM) decreased cell viability in a dose and time-response manner in both cell lines, showing a higher potency in MDA-MB-468 cells. Fucoxanthin presented anti-proliferative effects in lower concentrations in MDA-MB-468 compared to MDA-MB-231 cells after 48 h and 72 h. Angiogenesis studies showed that fucoxanthin (6.25 µM) downregulates VEGF-A and VEGF-C expression in TNF-α-stimulated (50 ng/ml) MDA-MB-231 cells, but not in MDA-MB-468 cells in the transcription and protein levels. Fucoxanthin induced apoptosis in MDA-MB-231 cells but did not affect MDA-MB-468 cells. Additionally, fucoxanthin inhibited migration and invasion in both cell lines, showing a higher percentage of the inhibition of migrated cells in MDA-MB-468 cells after 72 h. CONCLUSION: Fucoxanthin may be a promising candidate for breast cancer therapy by targeting VEGF-A, and VEGF-C, decreasing cell proliferation, inducing apoptosis, and inhibiting cell migration and invasion.
Citation Format: Shade' Ahmed, Patricia Mendonca, Samia Messeha, Ramesh Badisa, Karam F. Soliman. Fucoxanthin anti-tumor effects on the proliferation, angiogenesis, apoptosis, and migration of triple-negative breast cancer cells [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C021.
Abstract C087: Neighborhood influences on chronic hepatitis B monitoring behaviors among Asian Americans residing in Philadelphia county
Authors: Bhimla Aisha , Lu Wenyue , Zhu Lin , Tan Yin , Zhu Di , Truehart Jade , Yeh Ming-Chin , Nguyen Minhhuyen , Ma Grace X. 
Published: January 2023

Abstract
The incidence of liver and intrahepatic bile duct cancer for Asian Americans is almost 2 times greater in comparison to Non-Hispanic white women and men. A major factor that contributes to liver cancer is hepatitis b (HBV) infection, which disproportionally affects Asian Americans, who represent 7% of the total US population but makes up around 58% of HBV-linked hepatocellular carcinoma cases. The purpose of this study was to examine the relationship between the neighborhood environment, including neighborhood walkability, Asianicity, and neighborhood disadvantage on HBV monitoring related behavior such as doctors' visits and HBV blood testing among Asian HBV patients. A total of 160 study participants were recruited from March 2019 to March 2020 through combined recruitment approaches, including through medical record review by authorized staff from collaborating health clinics, pharmacies, or community health centers and community-based organizations including racial/ethnic based educational and community centers, religion-based organizations, and senior centers. Study measures included baseline assessment information including sociodemographics, HBV infection history, HBV monitoring behavior, and knowledge about HBV prevention, diagnosis and treatment. Neighborhood level measures included neighborhood disadvantage, Asianicity, and neighborhood walkability using census and online measures. Hierarchical generalized linear models (HGLM) were used to account for individual nested within neighborhoods for predicting factors associated with doctor’s visits and blood test. Greater neighborhood disadvantage (OR=0.97, 95% CI=0.95-0.99, p=0.0041) and Asianicity (OR=0.97, 95% CI=0.95-0.98, p=0.0003), and lower neighborhood walkability (OR=1.06, 95% CI=1.02-1.09, p=0.0039) were associated with a lower likelihood of doctor visits for CHB. Greater Asianicity (OR=0.97, 95% CI=0.96-0.99, p=0.0044) was associated with a lower likelihood of HBV blood testing in the past 6 months. Evident neighborhood environment effects suggest the need to incorporate these factors into interventions to enhance HBV self-monitoring behaviors and slow disease progression of chronic HBV.
Citation Format: Aisha Bhimla, Wenyue Lu, Lin Zhu, Yin Tan, Di Zhu, Jade Truehart, Ming-Chin Yeh, Minhhuyen Nguyen, Grace X. Ma. Neighborhood influences on chronic hepatitis B monitoring behaviors among Asian Americans residing in Philadelphia county [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C087.
Abstract C096: Obese adipose derived secretome stimulates triple negative breast cancer via stimulation of the mTOR pathway
Authors: Miracle Cora E. , Salisbury Travis , McCallister Chelsea 
Published: January 2023

Abstract
Background: Breast cancer remains the most common cancer amoung women with multipe risk factors including smoking, genetics, environmental factors, and obesity. Smoking and obesity are the top two risk factors for development of breast cancer, with smoking increasing the risk of development by 21% and obesity by 20-40%. Obesity increases the risk for all breast cancer subtypes, including triple negative breast cancer (TNBC) that is null for estrogen and progesterone receptors and the tyrosine kinase receptor, HER2. To this end, recent retrospective patient studies have shown that the majority of patients with TNBC were obese at the time of diagnosis. In addition, obese patients had a higher TNBC tumor grade and a higher staging. However, the signaling mechanisms that promote the progression of TNBC in obesity are not well understood. We published that adipose tissue (AT) derived secretome (ADS) in obesity promotes the invasiveness of estrogen receptor positive breast cancer cells. Based on these prior findings, we hypothesize ADS in obesity acts on TNBC cells to induce mTOR activity and in turn stimulates TNBC cell migration and invasiveness. Methods: De-identified peritumor (PT) breast AT samples were obtained with patient consent at the time of surgery for breast cancer treatment. Breast AT samples were cultured in serum free culture medium for 24 hours. After the incubation, the AT conditioned media was clarified by centrifugation. For this study, considered BMI less than 30 as lean-ADS (LADS) and BMI of 30 or greater as obese-ADS (OADS). ADS diluted 1:10 in serum free culture medium was applied to human MDA-MB-231 and MDA-MB-436 TNBC cells. Cell migration was assayed by the scratch assay. Images were taken at time 0, and 24 hours. Analysis was performed using image J. Western blot studies were performed to assay the levels of total and/or phosphorylated proteins. Results: OADS stimulated a statistically significant increase (1.5 fold) in TNBC cell migration compared with LADS. The increase in TNBC cell migration was associated with a significant increase (1.5 fold) in phosphorylated S6 in TNBC cells treated with OADS relative to LADS. Conclusion: Increases in mTOR activity in TNBC cells in response to OADS is associated with increased TNBC cell migration.
Citation Format: Cora E. Miracle, Travis Salisbury, Chelsea McCallister. Obese adipose derived secretome stimulates triple negative breast cancer via stimulation of the mTOR pathway [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C096.
Abstract C121: Epidemiological characteristics and patterns of recurrence of renal cell carcinoma in Hispanics: A single US center cohort study
Authors: Melo Abner Antonio Murray , Gallegos Jesus Antonio Ocejo , Merchan Jaime Rafael 
Published: January 2023

Abstract
Renal cell carcinoma (RCC) is amongst the ten most prevalent malignancies in the United States, with 76,000 new cases each year and almost 14,000 deaths. Over the past half-century, RCC has more than doubled in incidence. RCC seems to have a greater incidence among Hispanics with a nearly three-fold increase. The epidemiology of RCC has been studied. However, there is a gap in knowledge on disparities in RCC within minority populations. We aimed to analyze epidemiologic patterns of RCC within our community, where Hispanics alone make up 70% of the population. We conducted a retrospective study to describe characteristics and calculate rates of recurrence of RCC among patients treated at Sylvester Comprehensive Cancer Center in Miami, FL, from June 2010 to April 2020. The patients were aged 18 and older and had a pathologic diagnosis of RCC. We identified ethnicity as Hispanic/Latino (HL) or non-Hispanic/Latino (NHL). Clinical presentation was classified based on information from the last encounter as either local RCC without recurrence, metastatic RCC after nephrectomy, or metastatic RCC at diagnosis/de novo. We analyzed a total of 1168 patients, from which 661 patients (55.7%) were identified as NHL and 507 (42.7%) as HL. A subtotal of 333 patients (28.5%) had metastatic RCC at diagnosis/de novo, from which 199 (59.7%) were NHL, and 134 (40.2%) were HL. A subtotal of 835 patients (71.5%) were diagnosed with local RCC and underwent nephrectomy, from which 462 (55.3%) were identified as NHL and 373 (44.7%) as HL. From the NHL group that underwent nephrectomy, 189 patients (40.9%) had recurrent disease and 273 (59%) did not. From the HL group, 121 patients (32.4%) had recurrent disease and 252 (67.5%) did not. Overall, 310 patients had metastasis after nephrectomy, from which 121 (39%) were HL and 189 (60.9%) were NHL. In this cohort of patients with RCC, four out of every ten patients with metastasis at diagnosis were HL. NHL appeared to have more recurrence of disease after nephrectomy compared to Hispanics. Further histopathologic, clinical, and genomic characteristics will be presented, along with treatment outcomes and clinical trial participation in the NHL and HL cohorts.
Citation Format: Abner Antonio Murray Melo, Jesus Antonio Ocejo Gallegos, Jaime Rafael Merchan. Epidemiological characteristics and patterns of recurrence of renal cell carcinoma in Hispanics: A single US center cohort study [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C121.