bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication and characterization of multiphase bituminous materials for cold region pavements
Authors: Wang Di , Falchetto Augusto Cannone , Zhang Fan , Riccardi Chiara , Sun Yuxuan 
Published: April 2023

Abstract

In this study, the low temperature creep properties of multiphase bituminous materials (binder, mastic, Fine Aggregate Matrix - FAM, and mixture) were experimentally evaluated, and the impact of size effect on FAM and mixture specimen was also assessed. First, the mix design of mastic and FAM were performed based on the reference mixture AC 22 TS. The mathematical adaptation to the boundary sieve method was applied to calculate FAM gradation and binder content. Next, a preparation method was proposed to produce Fine Aggregate Matrix (FAM) in a laboratory environment, and scale-up slab samples were also fabricated for FAM and mixture specimens to evaluate the size effect phenomenon. Finally, three-point bending (3PB) creep tests were conducted on the multiphase bituminous specimens with different dimensions at -6°C, -12°C, and − 18°C with a modified Bending Beam Rheometer (BBR) device and a dynamic loading machine, depending on the sample size. Results indicate that the creep stiffness of the FAM was close to mixtures and much higher than the one observed in binder and mastic. The proposed fabrication approach provides a satisfactory method for preparing a representative FAM phase in the mixture, while the air voids can be easily adjusted during the slab compaction procedure. This study supports the idea of using FAM to discriminate asphalt mixtures for cold regions. The correlation between up-scaled FAM and mixtures specimens is recommended to be further investigated, including different mixture types and corresponding FAM.
Physical environment features that predict outdoor active play can be measured using Google Street View images
Authors: Boyes Randy , Pickett William , Janssen Ian , Swanlund David , Schuurman Nadine , Masse Louise , Han Christina , Brussoni Mariana 
Published: April 2023

Abstract
Childrens’ outdoor active play is an important part of their development. Play behaviour can be predicted by a variety of physical and social environmental features. Some of these features are difficult to measure with traditional data sources. This study investigated the viability of a machine learning method using Google Street View images for measurement of these environmental features. Models to measure natural features, pedestrian traffic, vehicle traffic, bicycle traffic, traffic signals, and sidewalks were developed in one city and tested in another. These models performed well for features that are time invariant, but poorly for features that change over time, especially when tested outside of the context where they were initially trained. This method provides a potential data source for the development of prediction models for a variety of physical and social environment features using publicly accessible street view images.
Exploring the potential role of diquarks in hadronization using semi-inclusive deep inelastic scattering on nuclear targets
Authors: Brooks William K , Fassi Lamiaa El , Chetry Taya 
Published: April 2023

Abstract
Hadronization, which is the process by which an energetic colored quark evolves into a color-singlet hadron in Quantum Chromodynamics, can be studied both in small nuclei and large nuclei, and the comparison of the differences between those two systems provides information about the hadronization mechanisms on femtometer distance scales. It can be argued that this process is well understood for light meson production on nuclei, but data from HERMES and CLAS for baryon production present puzzling patterns that are not well described by models. Herein we suggest that this might be due to the presence of diquarks in the protons and neutrons making up these nuclei.
Guiding the postoperative radioactive iodine-131 therapy for patients with papillary thyroid carcinoma according to the prognostic risk groups：a SEER-based study
Authors: Yang Yuping , Yi Kun , Han Shanshan , Lin Zijing , Zeng Bin , Shi Yanling , Ming Jia 
Published: April 2023

Abstract
Purpose: The effectiveness of iodine-131(131I) therapy in patients with papillary thyroid cancer (PTC) of various stage is controversial. This study aimed to use prognostic risk groups to guide 131I therapy in patients with PTC after radical thyroidectomy.
Methods: Data of 53484 patients with PTC after radical thyroidectomy were collected from the Epidemiology and End Results (SEER) database. Patients were divided into subgroups according to MACIS system and regional lymph node involvement. The prognostic role of 131I therapy was investigated by comparing Kaplan-Meier survival analysis and Cox proportional hazard models in different subgroups.
Results: Sex, age, tumor size, invasion, regional lymph node involvement, and distant metastasis was related to the survival of patients with PTC. If MACIS<7, 131I treatment didn’t affect the cancer-specific survival (CSS) rate. If MACIS ≥7, 131I therapy didn’t work on CSS rate for patients with N0 or N1a<5 status; 131I therapy had improved CSS rate for patients in the N1a≥5 or N1b status. If patients with distant metastasis, invasion, or large tumor, 131I therapy didn’t improve CSS rate for patients in N0 or N1a<5 stage.
Conclusion: After radical thyroidectomy, if MACIS<7, patients with PTC could avoid 131I therapy. If MACIS ≥7, patients in the N0 or N1a<5 could avoid 131I therapy; those in the N1a≥5 or N1b stage should be given 131I therapy. Among them, all patients with distant metastasis should be given 131I therapy.
Epilepsy as the Symptom of a Spinocerebellar Ataxia 13 in a Patient Presenting with a Mutation in the KCNC3 Gene
Authors: Li Shao , Shang Dandan , Du Yanjiao , Li Yan , Liu Ruihua 
Published: April 2023

Abstract
Background:The spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous Group of neurodegenerative diseases, among which SCAl3 is a rare subtype, and its pathogenic gene is the KCNC3 gene. At present, the incidence of SCA13 is still unclear, and only two cases have been reported in the Chinese population. We report a case of SCA13 with ataxia and epilepsy as the clinical manifestations. The diagnosis was confirmed by full-exome testing.
Case presentation:A 17-year-old young patient was unable to carry out many sports activities since childhood, and had repeated episodes of unconsciousness in the past 2 years. Neurologic examination revealed poor coordination of the lower extremities. Magnetic resonance imaging (MRI) of the brain performed cerebellar atrophy. Gene detection indicated that the patient had a heterozygous mutation of c.1268G>A in the KCNC3 gene (chr19:50826942). Urgent treatment with antiepileptic therapy was initiated; her seizures resolved shortly thereafter, and she remains seizure-free.The patient's condition had no obvious progress and aggravation with 1 year follow-up.
Couclusion:This case report suggests that ataxia patients with unknown causes, especially children and young onset patients, it is necessary to actively improve cranial MRI and genetic detection to make a clear diagnosis.Young patients with ataxia initially characterized by epilepsy and extrapyramidal system should first consider the possibility of SCA13.
Pulsed Vacuum Osmotic Dehydration (PVOD) of Fermented Beetroot: Modeling and Optimization by Response Surface Methodology (RSM)
Authors: Staniszewska Izabela , Nowak Konrad W. , Danuta Zielinska , Konopka Iwona , Zielinska Magdalena 
Published: April 2023

Abstract
Fermented beetroots can be osmotically dehydrated and then dried to make a nutritious snack known as fermented beet chips. To ensure the best product quality, it is necessary to determine optimal parameters of osmotic dehydration. Therefore, the aim of this study was to determine the optimal parameters of pulsed vacuum osmotic dehydration (PVOD) of fermented beetroot slices. The response surface methodology (RSM) was employed to optimize PVOD and improve the efficiency of the process. The experimental parameters considered: (T) processing temperature (20 < T < 40°C), (SC) sugar concentration (40 < SC < 60%), (VT) vacuum impregnation time (10 < VT < 50 min) and (ST) slice thickness (2 < ST < 6 mm). PVOD was optimized in terms of properties of beetroot tissue (hardness, HT, redness, a*T, water loss, WL, solid gain, SG) and osmotic solution (dry matter content, DMS, redness, a*S). The optimum qualities of beetroot tissue (HT=202.0 N, a*T=11.8, WL = 55.5%, SG = 7.1%) and osmotic solution (DMS=57.3%, a*S=38.9) were obtained at T = 20°C, SC = 60%, VT = 10 min, ST = 6 mm and T = 40°C, SC = 60%, VT = 50 min, ST = 2 mm, respectively.
Two wavelet multipliers and Landau-Pollak-Slepian operators on locally compact abelian groups associated to right-H-translation invariant functions
Authors: Nayak Santosh Kumar , Paul Swaraj 
Published: April 2023

Abstract
By using a coset of closed subgroup, we define a generalization of directionally sensitive variant Fourier like transform for locally compact abelian (LCA) topological groups. Further we have showed that this transform have some resembles with short time Fourier transform (STFT). For particular choices of LCA group and its closed subgroup, this operator gives directional STFT of function with respect to some windows. That means the present theory extends the theory of directional STFT in LCA groups. We study the interesting properties of two wavelet multipliers on locally compact abelian topological groups associated to this transform, known as generalized two wavelet multipliers, and show that these operators are Lp-bounded for 1 ≤ p ≤ ∞, and are in Schatten-von Neumann classes, Sp. For S1 class we obtain their traces, and finally determine the connection between generalized two wavelet multipliers and generalized Landau-Pollak-Slepian operators.
Mathematics Subject Classification (2010). Primary 47G10, 47G30, Secondary 42C40.
Sunspot Observations at the Eimmart Observatory: Revision and Supplement
Authors: Vokhmyanin Mikhail , Zolotova Nadezhda 
Published: April 2023

Abstract
Digital images of sunspot drawings of the archives of Georg Christoph Eimmart stored at the National Library of Russia are analyzed to obtain sunspot group numbers and sunspot areas as well as heliographic positions. Overall, more than a hundred drawings were processed. The impact of drawing and reproduction uncertainties and of the aims of historical observations are considered. The sunspot positions are compared to those reported by contemporary astronomers of the Maunder minimum. The restored sunspot group numbers and latitudes are compared to those extracted by Hoyt and Schatten as well as Hayakawa et al. The persistence of long-lived sunspots over several solar rotations is discussed.
Identification of novel phytochemicals from Hibiscus rosa sinensis flower as a prospective inhibitor targeting the 3CLpro enzyme of SARS-CoV-2 using computational approaches.
Authors: Das Subhadeep , Satapathy Sagarika , Acharya Diptikanta , Sahu Sushil Kumar 
Published: April 2023

Abstract
Hibiscus rosa sinensis had an infinite resources of phytochemicals, which had emerged as solutions for different health-related issues such as anti-diabetic, anti-microbial and wound healing activity as proved in past clinical studies. Focusing on the current situation, an incessant increase in daily COVID-19 cases and struggled to discover effective treatment measures for SARS-CoV-2 had led to a global health catastrophe. Upsurge in COVID-19 cases had revealed a pattern characterised as a first, second, third wave and beyond, this cycle of new SARS-CoV-2 variant transmission needed to be terminated by selecting a propitious effective target, and the 3CL protease enzyme (3CLpro or Mpro) of SARS-CoV-2 acts as a possible target. The objective of this study is to investigate the phytochemicals identified in Hibiscus rosa sinensis flower for their potential anti-SARS-CoV-2 properties virtually, targeting the 3CLpro or Mpro, which regulates viral pathogenesis. The present research protocol includes molecular docking of 34 phytochemicals identified from the Hibiscus rosa sinensis flower and targeted against the active site of the 3CLpro enzyme. Computational analysis revealed that the top 3 ligands, cyanidin-3-sophoroside-5-glucoside (-10.9 kcal/mol), 1,2-benzenedicarboxylic acid isodecyl octyl ester (-10.1 kcal/mol) and rutin (-9.3 kcal/mol) had better binding affinity as compared to the control inhibitor remdesivir (-8 kcal/mol). Further investigation in terms of ligand-protein interaction, physiochemical, ADMET and drug-likeness parameters showed that cyanidin-3-sophoroside-5-glucoside possessed promising properties and could act as a potentially effective drug candidate. However, our study needs to be supported by in vitro and in vivo evaluation to determine the precise mechanism of inhibitory action.
TP53 or CDKN2A/B covariation in ALK/RET/ROS1-rearranged NSCLC is associated with a high TMB, tumor immunosuppressive microenvironment and poor prognosis
Authors: Jiang Bin , Hu Liwen , Dong Daling , Guo Zixin , Wei Wei , Wang Chao , Shao Weikang , Ma Ting , Chen Yanhui , Li Qingyun , Hu Weidong 
Published: April 2023

Abstract
Introduction: ALK-rearranged lung adenocarcinomas with TP53 mutations have more unstable genomic features, poorer ALK-TKI efficacy and a worse prognosis than ALK-rearranged lung adenocarcinomas with wild-type TP53. Here, we examine the gene variations that co-occur with ALK/RET/ROS1 rearrangements in NSCLC and the corresponding tumor immune microenvironment, as well as their association with prognosis.
Methods: A total of 155 patients with ALK/RET/ROS1 fusions were included retrospectively. Tumor genome mutation analysis was performed by next-generation sequencing. PD-L1 expression and tumor-infiltrating lymphocytes were assessed by multiplex immunohistochemistry. The correlations among gene covariation, the tumor immune microenvironment, and clinicopathological characteristics were analyzed.
Results: Among the 155 patients, concomitant TP53 mutation appeared most frequently (31%), followed by CDKN2A/B copy number loss (15%). The ALK/RET/ROS1 fusion and TP53 or CDKN2A/B covariation group had more males and patients with stage IV disease (p<0.001, p=0.0066). Patients with TP53 or CDKN2A/B co-occurrence had higher tumor mutation burdens and more neoantigens (p<0.001, p=0.0032). PD-L1 expression was higher in the tumor areas of the TP53 or CDKN2A/B co-occurring group (p=0.00038). However, the levels of CD8+, CD8+PD1-, and CD8+PD-L1- TILs were lower in the tumor areas of this group (p=0.043, p=0.029, p=0.025). In the TCGA NSCLC cohorts, the top 2 mutated genes were CDKN2A/B (24%) and TP53 (16%). The TP53 or CDKN2A/B co-occurring group had higher tumor mutation burdens and shorter OS (p<0.001, p<0.001).
Conclusions: Patients with co-occurring TP53/CDKN2A/B variations and ALK/RET/ROS1 rearrangements are associated with high TMB, more neoantigens, an immunosuppressive microenvironment and a worse prognosis.
Comparison of pharmacokinetics and safety of albuvirtide in healthy subjects after intravenous drip and bolus injection
Authors: Qin Huiling , Yao Cheng , Zhang Wei , Hu Wei , Liu Yuantao , Yu Shuchang , Xie Dong , Hu Min , Ye Jun 
Published: April 2023

Abstract
Purpose. Albuvirtide (ABT) is the first long-acting HIV fusion inhibitor originally developed in China, blocking the invasion of HIV-1 virus into target cells. This study aimed to compare the pharmacokinetics, tolerability, and safety of ABT following a single intravenous (IV) bolus injection or intravenous drip in healthy Chinese subjects.Methods. A single-center, randomized, open-label, single-period, parallel phase I clinical trial was conducted. 30 subjects were randomly divided into 3 groups in a ratio of 1:1:1. After an overnight fast, all subjects received a single dose administration of 320 mg ABT by intravenous drip for 45 min (Group A) or bolus injection for 0.5 min (Group B) or bolus injection for 3 min (Group C). ABT plasma concentrations were analyzed using validated enzyme-linked immunosorbent assay. Noncompartmental analysis was used to evaluate PK parameters.Results. The median value of time to reach maximum concentration was 0.75 h in group A and 0.16 h in both group B and C, elimination half-life, mean residence time, apparent clearance and apparent volume of distribution was similar among three groups. The 90% confidence intervals of geometric mean ratios of PK parameters for group B and C relative to group C are mainly within 85–120%. All AEs in this study were mild, according to the CTCAE guidelines and the study investigator’s judgement.Conclusion. ABT bolus injection for 0.5 min and 3 min are expected well tolerated and to have similar pharmacokinetic characteristics as IV drip for 45 min, thus offering potential clinical benefits.
Finite element modeling of the hydrogen atom distribution on dented pipeline for hydrogen transport under cyclic loading
Authors: Zhao Jian , Cheng Frank 
Published: April 2023

Abstract
Repurposing existing natural gas pipelines for hydrogen transport requires an accurate assessment of the distribution of hydrogen (H) atoms at surface defects such as dents under frequent pressure fluctuations encountered on gas pipelines. In this work, a 3-dimensional finite element-based model was developed to determine the stress/strain and H atom concentrations at an unconstrained dent on an X52 steel pipe experiencing denting, spring-back and cyclic loading processes. As expected, a stress/strain concentration generates at the dent center, while the cyclic loading reduces the stress level and shifts the stress concentration zone from the dent center along the circumferential direction. As the dent depth increases, the maximum H atom concentration is further shifted from the dent center to the side. A coincident relationship between the maximum H atom concentration, von Mises stress, hydrostatic stress and plastic strain does not exist. Pressure fluctuations decrease both the stress and H atom concentrations, providing a beneficial effect on reduced risk of the dented pipelines to hydrogen embrittlement in high-pressure hydrogen gas environments. Further analysis shows that the indenter size has little influence on the H distribution in the dent area.
Cost-effectiveness analysis of robot-assisted gait training in patients with bilateral spastic cerebral palsy
Authors: Klobucká Stanislava , Klobucký Robert , Valovičová Katarína , Šiarnik Pavol , Kollár Branislav 
Published: April 2023

Abstract
BACKGROUND To date, there have been no published studies evaluating the cost-effectiveness of robot-assisted gait training (RAGT) in adolescent and adult patients with cerebral palsy (CP). The study´s aim was to analyse the cost-effectiveness of RAGT versus conventional kinesiotherapy (CON) from the health care provider’s perspective.METHODS We expressed the cost-effectiveness of RAGT in the Lokomat® system after analysing the costs and effects of RAGT and conventional therapy through the Incremental Cost-Effectiveness Ratio (ICER) based on a bicentric randomised controlled study, in which we demonstrated that the intensive RAGT regimen is more effective than conventional therapy in terms of improvements in gross motor functions in adolescent and adult patients with bilateral spastic CP.RESULTS According to the calculated ICER ratio for Lokomat®, an additional improvement per unit of effect (1% in GMFM), compared to conventional therapy, results in an average cost increase of EUR70.38 per patient in a therapeutic block consisting of 20 TUs (Therapeutic Units).CONCLUSION However, from the comprehensive analysis of the results and evaluation of the long-term effects, it follows that RAGT applied in adolescent and adult patients with bilateral spastic CP is not only more effective in terms of evaluation of monitored clinical parameters, but in the long term it is also more cost-effective compared to conventional therapy.
Assessment of Formaldehyde as a Larvicidal Agent against the Red Palm Weevil, Rhynchophorus ferrugineus (Curculionidae: Coleoptera)
Authors: Mohamed Hussein Farid , Ahmed Ahmed Waheed , Abdel-Hameid Naglaa Fekry 
Published: April 2023

Abstract

Red Palm Weevil (RPW), Rhynchophorus ferrugineus is widely regarded as the most serious pest of the date palm in worldwide, causing massive losses in palm crop and related industries. To prevent re-infestation, a promising chemical injection for effective control treatment at particularly high invested levels is required. Five different concentrations solution of formaldehyde in water were used to investigate the formaldehyde- RPW response. Results revealed that the concentration of 16% exhibited a remarkable effect on newly hatching and 2nd instar larvae of R. ferrugineus among all concentrations after 10 days exposure to poisoned medium. Data showed that there was significant increase in larval mortality by increasing the duration of exposure to formaldehyde. Data revealed that formaldehyde is potent against the larvae, thus, it could break down the life - cycle of R. ferrugineus and might be involved in the control programs of R. ferrugineus as a protective or curative material. In terms of LC50, the toxicity of formaldehyde on newly hatched larvae was the most effective. The time needed to cause mortality was decreased with increasing the concentration of the formaldehyde. Also, exposure of RPW to ascending concentrations of formaldehyde had significant effect between tested concentrations when applied on 4th instar larvae. The total lipids and total carbohydrates content decreased in all concentration treatments, while, no or slight decrease occurred in total protein, compared with those recorded in the control.
Characterizing Soil Permeability based on Response of Groundwater Level to River Stage using Regional Database
Authors: Kim Bokyung , Lee Jiyeong , Park Keunbo , Lee Junhwan 
Published: April 2023

Abstract
The coefficient of permeability (k) is an important soil property for various flow-related problems and site characterization. In this study, a new method for estimating kis proposed based on the response of groundwater level (GWL) to changes in river stage (RS). Focus was given on establishing a method to characterize regional permeability using local database without additional experimental testing procedure. For this purpose, the GWL-RS correlation model was introduced and adopted to establish a k correlation model based on the time response of GWL to RS. The effect of time delay between GWL response and RS was introduced into the process of characterizing k. The proposed method was calibrated using measured datasets of GWL and RS obtained from 17 different regions. Based on the results of comparison and calibration with measured datasets, a modification factor was established and introduced to achieve better match between estimated and measured values. To check the applicability of the proposed method, datasets from five different regions in US were collected and adopted into the comparison. It was confirmed that measured and predicted soil permeabilities were in reasonably close agreement.