bluuebunny/crossref_metadata_2025_split huggingface dataset:
KINERJA KEPALA SEKOLAH, DISIPLIN KERJA GURU DAN EFEKTIVITAS MANAJEMEN MUTU SMA SWASTA
Authors: Awaludin S Muhamad Robie 
Published: June 2023

Efektivitas manajemen mutu merupakan aspek yang sangat penting dan perlu mendapatkan perhatian khusus, karena mutu sekolah yang baik dapat diperoleh apabila manajemen mutu tersebut berjalan secara efektif. Tujuan penelitian ini yaitu mengetahui seberapa besar pengaruh kinerja kepala sekolah dan disiplin kerja guru terhadap efektivitas manajemen mutu SMA swasta se-kota Bandung. Metode penelitian yang digunakan adalah survey dengan pendekatan kuantitatif melalui analisis deskriptif. Sampel penelitian yang diambil sebanyak 30 sekolah. Teknik pengambilan sampel yang digunakan adalah teknik Proportionate Stratified Random Sampling. Hasil penelitian ini menunjukan bahwa kinerja kepala sekolah, disiplin kerja guru dan efektivitas manajemen mutu SMA swasta se-kota Bandung berada pada kategori tinggi. Selain itu, pengaruh kinerja kepala sekolah terhadap efektivitas manajemen mutu pada kategori rendah, pengaruh disiplin kerja guru terhadap efektivitas manajemen mutu pada Kategori sedang dan pengaruh kinerja kepala sekolah dan disiplin kerja guru terhadap efektivitas manajemen mutu pada kategori tinggi. Berdasarkan hasil penelitian, ada beberapa rekomendasi yang diperlukan untuk meningkatkan keefektifan manajemen mutu, diantaranya untuk terus melakukan perbaikan secara terus menerus dan melakukan dengan mengoptimalkan pendekatan total quality management (TQM).The effectiveness of quality management is a very important aspect and it needs special attention, because good quality of school can be obtained if the quality management is working effectively. The purpose of this research is to examine the influence of principal performance and teacher discipline towards effectiveness of quality management of private school throughout Bandung. The research used survey method with quantitative approach through descriptive analysis. A total of 30 schools out of a population of 109 schools were chosen as sample with proportionate stratified random sampling technique. These results revealed that principal performance, teachers discipline and effectiveness of quality management throughout the private high school in Bandung at the high category. Besides that, the the effect of principal performance towards effectiveness of quality management in low category, the effect of teacher discipline towards effectiveness of quality management in medium category, the effect of principal performance, teacher discipline towards effectiveness of quality management in high category. Based on the findings, the following recommendations are needed, for improving the effectiveness of quality management, such as continual improvements by optimizing and performing total quality management (TQM) approach.
IMPLEMENTASI ASPEK “INTELLECTUAL STIMULATION” PIMPINAN PENDIDIKAN TINGGI DALAM PENGEMBANGAN MUTU AKADEMIK
Authors: Ismaya Bambang 
Published: June 2023

Peneltian ini ini memaparkan tentang kepemimpinan tarnsformasional dilihat dari aspek intellektual stimulation dalam pengembangan mutu akademik pendidikan tinggi yang dilakukan di kampus UII Yogyakarta. Penelitian ini hendak menjawab pokok masalah tentang Bagaimana Implementasi aspek ”Intellectual Stimulation” pimpinan pendidikan tinggi dalam upaya menumbuhkan kreativitas dan inovasi di kalangan dosen dan stafnya dengan mengembangkan pemikiran kritis dan pemecahan masalah untuk menjadikan pendidikan tinggi kearah yang lebih baik dalam pengembangan mutu akademik. Bagaimana Pemimpin pendidikan tinggi mampu memberikan kejelasan menerangkan program kegiatan lembaga pendidikan menumbuhkan ide-ide baru dalam pengembangan mutu akademik di UII Yogyakarta. Bagaimana pimpinan pendidikan tinggi dalam kemampuannya memecahkan masalah serta pengambilan keputusan untuk pengembangan mutu akademik di UII Yogyakarta. Dalam penelitian digunakan penelitian kualitatif, dengan metode deskriptif. Pengumpulan data dilakukan dengan observasi, wawancara dan pengamatan yang sudah dituliskan dalam cacatan lapangan, dokumen pribadi, dokumen resmi, gambar dan poto. Berdasarkan hasil temuan penelitian menunjukan bahwa Upaya yang dilakukan oleh UII melakukan perubahan organisasi dengan mempertimbangkan perkembangan yang terjadi baik pada lingkungan internal maupun eksternal merupakan langkah maju dan strategis, dengan prilaku aspek intellektual stimulation dalam kepemimpinaannya.
PENGARUH BEBAN MENGAJAR TERHADAP PRODUKTIVITAS PENELITIAN MELALUI MOTIVASI KERJA
Authors: Dekawati Ipong , Sanjaya Aan Juhana , Tamam Badrud 
Published: June 2023

Dinamika perkembangan yang terjadi pada masyarakat internasional mendorong semua bangsa harus siap untuk bersaing. Terutama bersaing dalam percepatan mencapai kesejahrteraan. Untuk itu negara berikut bangsanya harus maju, agar dapat menyejahterakan warganya. Indikator kemajuan suatu bangsa, salah satunya melalui temuan dan inovasi yang memiliki kebaruan dan kebermanfaatan bagi masyarakat. Temuan baru dan inovasi tersebut dapat diraih melalui penelitian. Setiap institusi besar memiliki bagian yang membidangi penelitian dan pengembangan dengan apa yang disebutn research and development (RD). Dari semua institusi yang melaksanakan penelitian, sangat diharapkan lembaga pendidikan tinggi menjadi pelopornya. Sehingga muncullah salah satu tugas dosen yang telah menjadi beban kerja untuk melaksanakan penelitian dalam tiap semester atau sekurang-kurangnya dalam setiap tahunnya. Pertanyaannya adalah apakah setiap dosen terutama yang sudah dikategorikan profesional telah memenuhi tugas penelitian tersebut? Sangat kuat dugaan bahwa input dosen dengan output penelitiannya belum seimbang. Oleh karenanya, diperlukan penelitian yang seksama untuk mendapatkan alternatif solusinya. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif. Untuk mengungkapkan hubungan antar variabel dan dinyatakan dalam angka serta menjelaskannya dengan membandingkan antara teori-teori yang telah ada. Objek penelitian adalah seluruh perguruan tinggi swasta (PTS) di Kabupaten Indramayu
Bio-medical waste management practices of personal protective equipments pre and post Covid -19: A cross-sectional study
Authors: George James C , Babu Subin , Raj Rejul K , Mathew Deny 
Published: June 2023

: Covid-19 pandemic and the influx of polypropylene Personal Protective Equipments have created a new challenge in segregation and disposal of plastics. The general guidelines for disposal and segregation during the pre-covid period has emphasised recycling.Objective Our aim was to find out whether the PPE kits were adequately recycled during the pandemic and whether any toxic fumes were produced while incinerating them, resulting in any environmental hazard.: We collected the data on Bio-medical waste disposed in the entire Kerala state from 2017 to 2022. It was divided into pre-covid and covid-relaxation period. The amount of biomedical waste recycled and incinerated were measured and compared. The amount of new cases and its correlation to recycling and incineration was done. The stack emission data during pre-covid and covid-relaxation period was collected and compared.Our results showed that during the covid-relaxation years there was a significant increase in incineration as compared to the pre-covid years. The incineration was much more when compared to recycling. Fortunately the stack emission didn’t show any toxic fumes and environmental hazards.: We concluded that recycling of PPE was not adequate during covid-19 pandemic. Health care system should take more steps to be compliant with national guidelines. Awareness has to be made to decrease in the use of these disposable materials and shift to more eco-friendly materials or reusable materials.
Pulmonary Fibrosis in post COVID-19 follow up cases
Authors: Jain Harshit , Singapurwala Mustafa , Sarraf Shivmohan , Julka Arti 
Published: June 2023

An outbreak of novel coronavirus CoV-19(SARS-CoV-2) was responsible for coronavirus disease-19(COVID-19) and was first reported in Hubei province, Wuhan, China, on November 17, 2019. It had rapidly spread globally with approximately 66.4 crore cases, 64.40 crore recoveries and 67.1 lakh deaths (200,000 death within first four month) till now. In India there were 4.46 crore cases of which 4.41 crore recovered and there were 5.30 lakh deaths till now (JHU CSSE COVID-19 Data). Assessment of pulmonary fibrosis in post COVID-19 follow up cases. The prospective observational study was carried out at R.D. Gardi Medical College, Ujjain in the Department of Respiratory Medicine. All post COVID-19 cases attending post covid care speciality clinic was included in the study with minimum 119 patients. In our study of 119 post covid follow up cases, post covid pulmonary fibrosis was seen in 67(56.3%) patients (fibrotic group) of which only in 3 patients had residual lung fibrosis while other improved. The patients who had lung fibrosis were fewer than expected (&#60;5%). These sequelae were mostly occurring in the elderly patients with comorbidities, longer hospital stay, severity of covid infection and smoking are the other risk factors for its development. Post Covid patients had various symptoms like weakness, cough, breathlessness etc which required symptomatic management.
Improving antitumor targeting via using PL3 homing peptide and cell-penetrating peptide
Authors: Masheta Dhafir , Al-Azzawi Shafq 
Published: June 2023

Introduction: Tumor-homing peptides have gained great attention as tools for the development of non-invasive and targeting drug delivery systems (DDS) to minimize drug systemic toxicity and enhance bioavailability. This study aims to improve antitumor targeting in prostate cancer via uploading a drug to a DDS comprised of a cell penetrating peptide decorated with a tumor-homing peptide, PL3.
Material and Methods: The DDS was constructed via solid-phase peptide synthesis and then characterized via mass spectrum and high performance liquid chromatography. A cell viability assessment to evaluate its cytotoxicity on both tumor (prostate cancer cells) and normal cells was conducted, while a confocal laser scanning microscope and flow-cytometer were employed to investigate internalization. To inspect the effectiveness of the drug-loaded DDS, a biochemical enzyme inhibition assay on the target enzyme dihydrofolate reductase (DHFR) was performed. ‎
Results and Discussion:‏ The findings supported the succeeded synthesis and loading of the drug into this carrier system and demonstrated its high efficacy in cytotoxic effect and inhibiting DHFR with considerable cellular uptake in prostate cancer cells.
Conclusion: The drug was delivered to the target prostate cancer cells by the PL3-functionalized DDS, limiting its localization to tumor cells rather than normal cells. Therefore, the study results highlighted the significance of the DDS in tumor therapy interventions.
Graphical Abstact
CHARACTERIZATION AND CHEMICAL COMPOSITION OF SULFIDE ORES ORIGIN FROM WANGGAMETI VILLAGE, MATAWAI LAPAWU DISTRICT, EAST SUMBA REGENCY
Authors: Landi Pote Lodowik , Nadut Anggelinus 
Published: June 2023

Sulphide ore is one of the most abundant minerals in nature. Indonesia has a very diverse potential for minerals, ranging from iron ore, laterite iron ore, iron sand to iron sulphide ore. Sulphide ore is one of the minerals that has the potential to become the parent mineral for gold. One area that has sulfide ore is Wanggameti Village, Matawai Lapawu District, East Sumba Regency. This condition encourages research to be carried out with the aim of knowing the types of minerals in sulfide ores by XRD analysis and to identify the content of elements in sulfide ores by XRF analysis. The results showed that the results of XRD analysis of sulfide ore samples taken from Wanggameti Village, Matawai Lapawu District, East Sumba Regency contained minerals of the types Quartz (SiO2), Calsite (CaCO3), Corundum (Al2O3), Iron Aluminum Silicon (Fe3Al2Si3) and Muscovite 2M1 ( KAl2Si3AlO10(OH)2). And the results of the analysis of the content of elements in the sulfide ore with XRF is 36.6% Si; S 1.2%; K 5.0%; Ca 27.8%; Ti 1.98%; V 0.23%; Cr 0.09%; Mn 0.77%; Fe 19.3%; Ni 2.99%; Cu 0.43%; Zn 0.1%; Mo 2.8%; Ba 0.2%; Eu 0.2% and Re 0.3%.
Keywords:sulfide ore, mineral type and chemical composition
A Ketogenic Diet in Combination With Gemcitabine Mitigates Pancreatic Cancer Associated Cachexia in Male and Female KPC Mice
Authors: Cortez Natalia E , Pathak Suraj , Rodriguez Lanzi Cecilia , Hong Brian , Sule Rasheed O , Crone Ryman , Wang Fangyi , Chen Shuai , Gomes Aldrin , Baar Keith , Mackenzie Gerardo Guillermo 
Published: June 2023

Cancer associated cachexia (CAC) is a critical contributor to pancreatic ductal adenocarcinoma (PDAC) mortality. Thus, there is an urgent need for new strategies to mitigate PDAC-associated cachexia; and the exploration of dietary interventions is a critical component. We previously observed that a ketogenic diet (KD) combined with gemcitabine enhances overall survival in the autochthonous LSL-KrasG12D/+; LSL-Trp53 R172H/+; Pdx1-Cre (KPC) mouse model. In this study, we investigated the effect and cellular mechanisms of a KD in combination with gemcitabine on the maintenance of skeletal muscle mass in KPC mice. For this purpose, male and female pancreatic tumor-bearing KPC mice were allocated to a control diet (CD), a KD, a CD + gemcitabine (CG), or a KD + gemcitabine (KG) group. We observed that a KD or a KG mitigated muscle strength decline over time and presented higher gastrocnemius weights compared CD-fed mice. Mechanistically, we observed sex-dependent effects of KG treatment, including the inhibition of autophagy, and increased phosphorylation levels of eIF2α in KG-treated KPC mice when compared to CG-treated mice. Our data suggests that a KG results in preservation of skeletal muscle mass. Additional research is warranted to explore whether this diet-treatment combination can be clinically effective in combating CAC in PDAC patients.
PENGUATAN PERAN PEREMPUAN DALAM PENDIDIKAN: PEMBERDAYAAN PARA USTADZAH PESANTREN MUHAMMADIYAH KABUPATEN MADIUN DALAM MENGAKSES KITAB BERBAHASA ARAB GUNDUL
Authors: Cahyo Agus Tri 
Published: June 2023

Banyak peran yang dimainkan para perempuan (baca: para ustadzah) di Pesantren Muhammadiyah kabupaten Madiun. Hal ini tentunya tidak lepas dari dua misi besar yang dikembangkan oleh Muhammadiyah, yaitu tajrîd dan tajdîd. Tajrîd artinya pemurnian, yaitu melakukan proses pembersihan dari sinkretisme yang ada pada cara beribadah warganya. Sedangkan tajdîd berarti adanya upaya pembaharuan dalam memahami Islam, khususnya dalam hal-hal yang terkait dengan ranah peradaban. Para perempuan di pesantren Muhammadiyah berupaya untuk bisa melaksanakan dua misi besar tersebut. Hal ini terlihat dengan banyaknya peran yang dimainkan di pesantren, sejak dari bergabungnya dalam pengelolaan lembaga Darul Qur’an yang melakukan pembelajaran al-Qur’an metode ummi, kegiatan pesantren Sabtu Ahad, pembinaan seni beladiri Tapak Suci Putra Muhammadiyah, penanganan anak asuh dan pelibatan pada penanganan kelompok bermain. Namun hal yang masih mengganjal adalah minimnya peran perempuan dalam pembelajaran kepesantrenan, khususnya dalam pembelajaran kitab berbahasa Arab. Pengabdian ini dilakukan dalam rangka pemberdayaan problem dimaksud.
PENINGKATAN KETERAMPILAN MENGAJAR MATERI IPA DAN MATEMATIKA BERBASIS LABORATORIUM BAGI GURU KELAS MADRASAH IBTIDAIYAH DI KECAMATAN MLARAK, PONOROGO
Authors: Hidayati Kurnia , Wathoni Kharisul , Widayanti Esti Yuli 
Published: June 2023

Kegiatan ini merupakan program Pengabdian kepada Masyarakat dari dosen di lingkup Institut Agama Islam Negeri Ponorogo pada tahun 2021. Dengan mengacu pada kluster pengabdian peningkatan program studi maka pengabdian ini memilih sasaran madrasah ibdidaiyah di lingkup kabupaten Ponorogo. Sasaran dari Pengabdian adalah guru kelas madrasah ibtidaiyah di kecamatan Mlarak sebanyak 25 orang guru. Tujuan dari program pengabdian adalah meningkatkan keterampilan guru kelas dalam pembelajaran berbasis laboratorium untuk pembelajaran materi IPA dan matematika. Metode pengabdian yang digunakan adalah dengan pendekatan edukatif dalam bentuk pelatihan atau workshop. Workshop dilaksanakan dengan strategi pembelajaran langsung menggunakan teknik ceramah, diskusi, demonstrasi, dan praktik. Output atau luaran dari kegiatan pengabdian ini adalah guru kelas yang terampil dalam melaksanakan langkah- langkah pengajaran matematika dan IPA berbasis laboratorium serta guru yang terampil dalam penggunaan alat laboratorium untuk pembelajaran materi IPA dan matematika.
SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response
Authors: Dziembowski Andrzej , Krawczyk Pawel , Mroczek Seweryn , Gewartowska Olga , Mazur Michał , Orzeł Wiktoria , Matylla-Kulińska Katarzyna , Jeleń Sebastian , Turowski Paweł , Śpiewla Tomasz , Tarkowski Bartosz , Tudek Agnieszka , Brouze Aleksandra , Wesołowska Aleksandra , Nowis Dominika , Gołąb Jakub , Kowalska Joanna , Jemielity Jacek 
Published: June 2023

Abstract
Though mRNA vaccines against COVID-19 have revolutionized vaccinology and have been administered in billions of doses, we know incredibly little about how mRNA vaccines are metabolized in vivo. Here we implemented enhanced nanopore Direct RNA sequencing (eDRS), to enable the analysis of single Moderna’s mRNA-1273 molecules, giving in vivo information about the sequence and poly(A) tails.

We show that mRNA-1273, with all uridines replaced by N1-methylpseudouridine (mΨ), is terminated by a long poly(A) tail (~100 nucleotides) followed by an mΨCmΨAG sequence. In model cell lines, mRNA-1273 is swiftly degraded in a process initiated by the removal of mΨCmΨAG, followed by CCR4-NOT-mediated deadenylation. In contrast, intramuscularly inoculated mRNA-1273 undergoes more complex modifications. Notably, mRNA-1273 molecules are re-adenylated after mΨCmΨAG removal. Detailed analysis of immune cells involved in antigen production revealed that in macrophages, after mΨCmΨAG removal, vaccine mRNA is very efficiently re-adenylated, and poly(A) tails can reach up to 200A. In contrast, in dendritic cells, vaccine mRNA undergoes slow deadenylation-dependent decay. We further demonstrate that enhancement of mRNA stability in macrophages is mediated by TENT5 poly(A) polymerases, whose expression is induced by the vaccine itself. Lack of TENT5-mediated re-adenylation results in lower antigen production and severely compromises specific immunoglobulin production following vaccination.

Together, our findings provide an unexpected principle for the high efficacy of mRNA vaccines and open new possibilities for their improvement. They also emphasize that, in addition to targeting a protein of interest, the design of mRNA therapeutics should be customized to its cellular destination.
Effects of spirulina (Spirulina platensis) supplementation in feed on reproductive performance in rabbit (Oryctolagus cuniculus) does
Authors: Momo Chongsi Margaret Mary Mary , Adam Mahamat Tahir Markhous , Hervé Tchoffo , Magloire Bend Emma Fortune , Narcisse Vemo Bertin , Bertine Noumbissi Marie Noel , Ferdinand Ngoula , Joseph Tchoumboue 
Published: June 2023

Abstract
The aim of this study was to evaluate the effect of dietary supplementation with spirulina powder on the reproductive characteristics in female rabbits. Twenty-one nulliparous and sexually mature rabbits (8 months old) were divided into 3 groups of 7 animals each, comparable in terms of body weight. After one week of feeding with the experimental diet, rabbits in each group were mated. During the experiment, does in group 1 (control group) received ad libitum a diet without spirulina (control diet), while does of groups 2 and 3 received diets supplemented with spirulina powder at 0.6% and 1.2% respectively. compared to control group, the live weights of animals treated with spirulina increased, while there was no significant difference (P > 0.05). The male acceptance and kids viability rates were insignificantly (P > 0.05) higher and the delay of male acceptance was lower in females fed diet containing spirulina as compared to control females. The rate of fertility, the sex ratio males/females of the young and duration of gestation were comparable in all the groups (P > 0.05). The number of young rabbits post-partum was insignificantly (P > 0.05) greater in does receiving spirulina-supplemented feed than control animals. Therefore, the results from this work show that supplementation of diet with spirulina powder could ameliorate reproductive performances in female rabbits, especially at 1.2%, as better performances were recorded at this percentage.
Interpretable scRNA-seq Analysis with Intelligent Gene Selection
Authors: Zhang Xinyu , Jin Kaixiu , Ni Tianhao , Pei Guanxiong , Xue Nan , Yan Guanao , Li Taihao , Li Bingjie 
Published: June 2023

Abstract
Single-cell RNA sequencing (scRNA-seq) data analysis is confronted with multiple challenges, including high dimensionality, substantial noise, and information loss. To effectively address these issues, we introduce scAIG, a robust and transparent single-cell analysis framework. scAIG utilizes an intelligent gene selection method, which systematically identifies the most informative genes for clustering based on the Normalized Mutual Information (NMI) between the pre-learned pseudo-labels and quantified genes. Furthermore, scAIG incorporates a scale-invariant distance for assessing cell-to-cell similarity, which enhances connection between homologous cells and ensures more accurate and robust results. Through comprehensive comparisons with existing state-of-the-art techniques, scAIG demonstrates superior performance in both clustering accuracy and visualization quality. Our in-depth analysis of the clustering results further reveals that scAIG can uncover intricate stage-specific gene expression patterns during the same period of cell development.
Accurate and Generalizable Soil Liquefaction Prediction Model Based on the CatBoost Algorithm
Authors: He Jiazhi , Feng Xianda , Lu  
Published: June 2023

Abstract
Accurate prediction of soil liquefaction is important for preventing geological disasters. Soil liquefaction prediction models based on machine learning algorithms are efficient and accurate; however, the generalizability of some models is weak and they fail to achieve highly precise soil liquefaction predictions in certain areas, which limits the applicability of these models. Thus, a soil liquefaction prediction model was constructed using the CatBoost (CB) algorithm to support categorical features. The model was trained using standard liquefaction datasets from domestic and foreign sources and was optimized with Optuna hyperparameters. Additionally, the model was evaluated using five evaluation metrics and its performance was compared to that of other models that use multi-layer perceptron and support vector machine algorithms. Finally, the prediction capability of the model was verified by a case study. The experimental results demonstrated that the CB-based model generated more accurate soil liquefaction predictions than other comparison models and maintained their performance. Hence, the proposed model accurately predicts soil liquefaction and offers strong generalizability, demonstrating potential to contribute toward the prevention and control of soil liquefaction in engineering projects, and toward ensuring the safety and stability of structures built on or near liquefiable soils.