bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical outcomes of a prospective, phase 2 trial of robotic surgery for resectable right‐sided colon cancer (the ROBOCOLO trial)
Authors: Numata Masakatsu , Watanabe Jun , Ishibe Atsushi , Ozawa Mayumi , Suwa Yusuke , Kazama Keisuke , Nakagawa Kazuya , Atsumi Yosuke , Rino Yasushi , Saito Aya , Kunisaki Chikara , Endo Itaru 
Published: July 2023

AbstractAimWe evaluated the safety of robotic surgery for right‐sided colon cancer in Japan.MethodsThis was a prospective, open‐label, single‐arm phase II trial conducted at two institutions. Patients ≥20 years old with stage I–III right‐sided colon cancer and scheduled for radical resection with ≥D2 lymph node dissection were eligible. The criterion for surgeons was experience performing robot‐assisted rectal resection in ≥40 cases. The primary endpoint was the postoperative complication rate ≤30 days after surgery.ResultsFrom August 2021 to February 2023, 42 patients were enrolled; three were excluded, with 39 analyzed as the full analysis set. The median age was 72 years, and the median body mass index was 23.2. The tumor was located in the cecum in 13 cases (33.3%), ascending colon in 20 cases (51.3%), and transverse colon in six cases (15.4%). Ileocolic resection was performed in 17 cases (43.5%) and right hemicolectomy in 22 cases (56.5%), both with D3 lymph node dissection. The median console time was 109 min, and the operative time was 170 min. The mean blood loss was 7.7 mL. Intracorporeal anastomosis was performed in 28 patients (71.8%). There were no conversions and no intraoperative adverse events. The median postoperative stay was 5 days. Postoperative complications occurred in four patients (10.2%; paralytic ileus [n = 3] and pneumonia [n = 1]). All postoperative complications were grade 1 or 2, with no mortalities noted. R0 resection was achieved in all patients.ConclusionsThis study demonstrated the safety and feasibility of robotic surgery for right‐sided colon cancer.
Novel homozygous LAMB1 in‐frame deletion in a pediatric patient with brain anomalies and cerebrovascular event
Authors: Toutouna Louiza , Beck‐Woedl Stefanie , Feige Ursula , Glaeser Birgitta , Komlosi Katalin , Eckenweiler Matthias , Luetzen Niklas , Haack Tobias B. , Fischer Judith , Bader Ingrid , Tzschach Andreas 
Published: July 2023

AbstractBiallelic pathogenic variants in LAMB1 have been associated with autosomal recessive lissencephaly 5 (OMIM 615191), which is characterized by brain malformations (cobblestone lissencephaly, hydrocephalus), developmental delay, and epilepsy. Pathogenic variants in LAMB1 are rare, with only 11 pathogenic variants and 11 patients reported to date. Here, we report on a 6‐year‐old patient from a consanguineous family with profound developmental delay, microcephaly, and a history of a perinatal cerebrovascular event. Brain magnetic resonance imaging (MRI) showed cerebellar cystic defects, signal intensity abnormalities, and a hypoplastic corpus callosum. Trio‐exome analysis revealed a homozygous in‐frame deletion of Exons 23 and 24 of LAMB1 affecting 104 amino acids including the epidermal growth factor (EGF)‐like units 11 and 12 in Domain III. To our knowledge, this is the first reported in‐frame deletion in LAMB1. Our findings broaden the clinical and molecular spectrum of LAMB1‐associated syndromes.
Use of nonsteroidal anti‐inflammatory drugs and poor olfaction in women
Authors: Chamberlin Keran W. , Li Chenxi , Luo Zhehui , D'Aloisio Aimee A. , Pinto Jayant M. , Sandler Dale P. , Chen Honglei 
Published: July 2023

AbstractBackgroundIt is unclear whether regular use of nonsteroidal anti‐inflammatory drugs (NSAIDs) is associated with poor olfaction in older adults.MethodsWe selected 4020 participants, aged 50 to 79 years in 2018, from 36,492 eligible participants in the National Institute of Environmental Health Sciences Sister Study, according to their self‐reported olfaction status. Of these, 3406 women completed the 12‐item Brief Smell Identification Test. We defined poor olfaction as a test score ≤9 in the primary analysis. We then estimated odds ratios (ORs) and 95% confidence intervals (CIs) from weighted logistic models, accounting for the study design, missing exposures/outcomes, and covariates.ResultsOverall, NSAID use was not associated with poor olfaction. However, we found evidence for potential multiplicative interactions. Specifically, the OR comparing regular versus never use of aspirin was 1.8 (95% CI, 1.1–3.2) among women who had not regularly used nonaspirin NSAIDs, while the corresponding OR was 0.8 (95% CI, 0.5–1.2) among nonaspirin NSAID users (P for interaction = 0.016). Similar results were seen for ibuprofen alone versus ibuprofen with other NSAID use (P for interaction = 0.010). Among women using either drug alone, associations with poor olfaction increased with increasing duration and cumulative dose. Post hoc analyses showed that the interactions could not be readily explained by potential biases. Other NSAIDs were not associated with olfaction.ConclusionLong‐term regular use of aspirin or ibuprofen was associated with poor olfaction among women who never regularly used other types of NSAIDs. These preliminary findings warrant independent confirmation.
Hydrocortisone metabolism by Staphylococcus: Effects on anti‐inflammatory and antimicrobial action
Authors: Cherian Lisa Mary , Liu Sha , Hon Karen , Ramezanpour Mahnaz , Hu Hua , Javadiyan Shari , Stafford Irene , Wormald Peter‐John , Psaltis Alkis James , Vreugde Sarah 
Published: July 2023

Key Points
Hydrocortisone 21‐hemisuccinate (HCHS) influenced the growth and metabolism of Staphylococcus aureus
S. aureus metabolic activity was high and antibiotic susceptibility low at 1.4 mg/mL HCHS
S. aureus metabolized HCHS to cortisol and reduced poly(I:C)‐induced IL‐6 secretion
Effects of Iron Species on Low Temperature CO2 Electrolyzers
Authors: Staerz Anna F. , van Leeuwen Marieke , Priamushko Tatiana , Saatkamp Torben , Endrődi Balázs , Plankensteiner Nina , Jobbagy Matias , Pahlavan Sohrab , Blom Martijn J. W. , Janáky Csaba , Cherevko Serhiy , Vereecken Philippe M. 
Published: July 2023

AbstractElectrochemical energy conversion devices are considered key in reducing CO2 emissions and significant efforts are being applied to accelerate device development. Unlike other technologies, low temperature electrolyzers have the ability to directly convert CO2 into a range of value‐added chemicals. To make them commercially viable, however, device efficiency and durability must be increased. Although their design is similar to more mature water electrolyzers and fuel cells, new cell concepts and components are needed. Due to the complexity of the system, singular component optimization is common. As a result, the component interplay is often overlooked. The influence of Fe‐species clearly shows that the cell must be considered holistically during optimization, to avoid future issues due to component interference or cross‐contamination. Fe‐impurities are ubiquitous, and their influence on single components is well‐researched. The activity of non‐noble anodes has been increased through the deliberate addition of iron. At the same time, however, Fe‐species accelerate cathode and membrane degradation. Here, we interpret literature on single components to gain an understanding of how Fe‐species influence low temperature CO2 electrolyzers holistically. The role of Fe‐species serves to highlight the need for considerations regarding component interplay in general.
Enhancement of the effective thermal conductivity of iron oxide‐coated hexagonal boron nitride/polyimide composite sheets using samarium–cobalt magnets
Authors: Itaoka Takuro , Matsubayashi Ryohei , Haruki Masashi 
Published: July 2023

AbstractThe orientation and distribution of the filler in hexagonal boron nitride (hBN) coated with iron oxide (Fe3O4@hBN)/polyimide (PI) composite sheets were controlled via magnetic field treatment (MFT) to enhance the effective thermal conductivity (TC) in the out‐of‐plane direction. Filler chain structures gradually formed in the direction of the magnetic field in the precursor solution. The effective TC of the Fe3O4@hBN/PI sheet after MFT was much higher than that of pristine hBN/PI. The effective TC of the composites was preferably improved by placing the sample near a one‐sided magnet instead of in the middle of a pair of magnets. The effective TC of 10, 20, and 30 vol% Fe3O4@hBN/PI composites improved by 59%, 53%, and 35%, respectively, compared to that of pristine hBN/PI for a magnet distance of 10 mm and with the sample placed 2 mm from the bottom magnet. These values are in good agreement with those reported in the literature using MFT. The tensile strengths of the 10, 20, and 30 vol% Fe3O4@hBN/PI composites prepared using MFT were 33%, 33%, and 22% lower, respectively, than those of the composites prepared without MFT.
ReaxFF reactive force field model enables accurate prediction of physiochemical and mechanical properties of crystalline and amorphous shape‐memory polyurethane
Authors: Afroz Mohammad M. , Shin Yun Kyung , van Duin Adri C. T. , Li‐Oakey Katie D. 
Published: July 2023

AbstractWe investigate reactive force field (ReaxFF) prediction of physiochemical and mechanical properties, and stimuli response behavior of a shape‐memory polyurethane (SMPU) rigid segment. We used SMPUs as a platform to link the rigid/hard segment domain crystallinity with properties that can also be experimentally measured. Specifically, we developed models for crystalline and amorphous forms of a common rigid segment of SMPUs, for example, 4,4′‐diphenylmethane diisocyanate (MDI) with n‐butanediol (BDO), denoted as MDI‐BDO. ReaxFF molecular dynamics simulations with equilibrium dynamics are performed by controlling mass, temperature, and pressure or volume to predict the structural and physiochemical properties of crystalline and amorphous rigid segments of SMPU systems, followed by simulating their XRD and FTIR patterns, respectively. Non‐equilibrium ReaxFF simulations are implemented by using uniaxial box deformation technique to study response‐behavior of crystalline SMPU under tensile loading and during stress‐relaxation. The model and simulation scheme presented in this study demonstrates a robust theoretical pathway toward application‐dictated, on‐demand design of high‐performance SMPUs in applications such as soft robotics.
Femtosecond Laser‐Induced Periodic Surface Structuring of the Topological Insulator Bismuth Telluride
Authors: Hu Meilin , JJ Nivas Jijil , Salvatore Marcella , Oscurato Stefano L. , Guarino Anita , Fittipaldi Rosalba , Amoruso Salvatore , Vecchione Antonio 
Published: July 2023

AbstractSurface structuring of topological insulator Bi2Te3 single crystals with femtosecond laser by varying pulses N and energy E is reported. Interesting effects related to laser‐induced periodic surface structures formation in this class of materials are evidenced. At low pulse energy, a clear formation of periodic, subwavelength ripples oriented orthogonally to the laser polarization is observed; those are restricted to an annular region surrounding a featureless central disk as the laser energy progressively increases. The structural analysis shows that some degree of crystallinity is preserved in the rippled area, but the central disk is amorphous resembling what is observed for germanium (Ge) and is associated with the hindering of surface structure formation due to a thick melted surface layer. Interestingly, at larger fluence or number of pulses, a transition to suprawavelength grooves occurs within the annular region covered by surface structures. The findings demonstrate a clear incubation behavior, suggesting that the formation of laser‐induced periodic surface structures is coherent with the general features of the process already reported for other materials. However, the disappearance of these structures in the central area, possibly resulting from the influence of the depth of the melt layer, indicates a mixed behavior for Bi2Te3.
Dual‐mode security authentication of SrAl2O4:Eu,Dy phosphor encapsulated in electrospun cellulose acetate nanofibrous films
Authors: El‐Newehy Mohamed , El‐Hamshary Hany , Abdul Hameed Meera Moydeen 
Published: July 2023

AbstractPhotochromic inks have been an attractive authentication strategy to improve the anti‐counterfeiting efficiency of commercial products. However, recent reports have shown significant disadvantages with photochromic inks, including poor durability and high cost. In this context, we developed novel photochromic nanofibres for advanced anti‐counterfeiting applications. Lanthanide‐doped strontium aluminate (LdSA) nanoparticles (NPs) were prepared and immobilized into electrospun cellulose acetate nanofibres (CANF). Authentication materials immobilized with inorganic photochromic agents can warranty durability and photostability. Therefore, the ultraviolet‐stimulated photochromism of LdSA‐encapsulated cellulose acetate nanofibres (LdSA@CANF) demonstrated high reversibility and photostability. A broad range of cellulose acetate nanofibres with unique emission characteristics was developed when applying different ratios of LdSA NPs. LdSA@CANF appeared colourless under visible daylight, whereas a green emission was monitored under ultraviolet‐light illumination. The shape and chemical content of the photochromic fibrous films were examined using various analytical techniques. The mechanical characteristics of LdSA@CANF‐coated paper were investigated. The emission wavelength was detected at 514 nm to designate green colour, whereas the excitation wavelength was detected at 369 nm to indicate transparency. The prepared cellulose acetate nanofibrous film can be described as an efficient strategy for the anti‐counterfeiting of commercialized items.
Induction chemotherapy‐based organ‐preservation protocol improve the function preservation compared with immediate total laryngectomy for locally advanced hypopharyngeal cancer—Results of a matched‐pair analysis
Authors: Yang Yifan , Feng Ling , Zhong Qi , Zhang Yang , Huang Zhigang , Zhang Shurong , Li Shuling , Gao Junmao , Hou Lizhen , Ma Hongzhi , He Shizhi , Shi Qian , Lian Meng , Zhao Yanming , Shen Xixi , Chen Jiaming , Wang Lingwa , Li Haiyang , Chen Shaoshi , Xu Jiaqi , Wang Ru , Fang Jugao 
Published: July 2023

AbstractBackgroundWe performed a paired analysis to compare the therapeutic effect between the induction chemotherapy‐based organ‐preservation approach and immediate total laryngectomy in hypopharyngeal squamous cell carcinoma patients requiring total laryngectomy.Methods351 patients who were treated with organ‐preservation approach were compared with 110 patients who were treated with total laryngectomy. The main measures and outcomes were progression‐free survival (PFS), overall survival (OS), and larynx function preservation survival (LFPS).ResultsNo statistical difference was observed for 3‐, 5‐, and 10‐year PFS and OS in two groups. In the organ‐preservation group, the 3‐, 5‐, and 10‐year LFPS was 30.7%, 23.3%, and 16.6%, respectively. The LFPS of Stage III > Stage IV, N0 > N1 > N2 > N3, T2 > T3 > T4, CR > PR > SD > PD patients (all p values <0.05).ConclusionsSurvival outcomes did not significantly differ between the two groups. The organ‐preservation approach allowed more than 70% of the survivors to retain their larynx function.
An unusual no‐reflow phenomenon due to neointimal tissue embolization during drug eluting balloon intervention in stent restenosis: A case report
Authors: Kim Sung Eun , Choi Ki Hong , Song Young Bin 
Published: July 2023

AbstractAcute coronary syndrome is one of the leading causes of death worldwide. Percutaneous coronary intervention (PCI), along with various devices, have been technically developed to dramatically improve mortality risk in patients with acute myocardial infarction. However, no‐reflow phenomenon still remains a problematic complication during a PCI, even in the era of drug eluting stents. There are various hypotheses and mechanisms for no‐reflow phenomenon, but none have been confirmed. Treatment for no‐reflow phenomenon also depends on various underlying conditions, but have not yet shown effective improvement. We presented a case of no‐reflow phenomenon caused by an unusual cause.
Substrate Selectivity Imparted by Self‐Assembled Molecular Containers and Catalysts
Authors: Lorenzetto Tommaso , Bordignon Francesca , Munarin Luca , Mancin Fabrizio , Fabris Fabrizio , Scarso Alessandro 
Published: July 2023

AbstractRecent trends in catalysis are devoted to mimicking some peculiar features of enzymes like site selectivity, through functional group recognition, and substrate selectivity, through recognition of the entire surface of the substrate. The latter is a specific feature of enzymes that is seldomly present in homogeneous catalysis. Supramolecular catalysis, thanks to the self‐assembly of simple subunits, enables the creation of cavities and surfaces whose confinement effects drive the preferential binding of a substrate among others with consequent substrate selectivity. The topic is an emerging field that exploits recognition phenomena to discriminate the reagents based on their size and shape. This review deals this cutting‐edge field of research covering examples of supramolecular self‐assembled molecular containers and catalysts operating in organic as well as aqueous media, with special emphasis for catalytic systems dealing with direct competitive experiments involving two or more substrates.
Cobalt‐Catalyzed Decarboxylative Allylations: Development and Mechanistic Studies
Authors: Joseph Ebbin , Hernandez Rafael D. , Tunge Jon A. 
Published: July 2023

AbstractIn recent years, there has been a concerted drive to develop methods that are greener and more sustainable. Being an earth‐abundant transition metal, cobalt offers an attractive substitute for commonly employed precious metal catalysts, though reactions engaging cobalt are still less developed. Herein, we report a method to achieve the decarboxylative allylation of nitrophenyl alkanes, nitroalkanes, and ketones employing cobalt. The reaction allows for the formation of various substituted allylated products in moderate‐excellent yields with a broad scope. Additionally, the synthetic potential of the methodology is demonstrated by the transformation of products into versatile heterocyclic motifs. Mechanistic studies revealed an in situ activation of the Co(II)/dppBz precatalyst by the carboxylate salt to generate a Co(I)‐species, which is presumed to be the active catalyst.
Synthesis and Structure of the Inclusion Compound COF300‐ALA
Authors: Hong Yuexian , Zhang Mingxuan , Zhou Zhipeng , Zhu Zhenyu , Lu Jiaxing , Sun Junliang , Zheng Zhikun 
Published: July 2023

Comprehensive SummaryFinding a new multimolecular lattice inclusion host is still challenging. We report the synthesis and the crystal structure of the first example of an inclusion compound COF300‐ALA by using three‐dimensional covalent organic frameworks (3D‐COFs) as the multimolecular host lattice. The guest‐host dynamics upon inclusion and exclusion of the gust molecule are uncovered in a 3D covalent organic framework.
Patients hospitalized with acute heart failure, worsening renal function, and persistent congestion are at high risk for adverse outcomes despite current medical therapy
Authors: Cooper Lauren , DeVore Adam , Cowger Jennifer , Pinney Sean , Baran David , DeWald Tracy A. , Burt Tara , Pietzsch Jan B. , Walton Antony , Aaronson Keith , Shah Palak 
Published: July 2023

AbstractIntroductionApproximately 1/3 of patients with acute decompensated heart failure (ADHF) are discharged with persistent congestion. Worsening renal function (WRF) occurs in approximately 50% of patients hospitalized for ADHF and the combination of WRF and persistent congestion are associated with higher risk of mortality and HF readmissions.MethodsWe designed a multicenter, prospective registry to describe current treatments and outcomes for patients hospitalized with ADHF complicated by WRF (defined as a creatinine increase ≥0.3 mg/dL) and persistent congestion at 96 h. Study participants were followed during the hospitalization and through 90‐day post‐discharge. Hospitalization costs were analyzed in an economic substudy.ResultsWe enrolled 237 patients hospitalized with ADHF, who also had WRF and persistent congestion. Among these, the average age was 66 ± 13 years and 61% had a left ventricular ejection fraction (LVEF) ≤ 40%. Mean baseline creatinine was 1.7 ± 0.7 mg/dL. Patients with persistent congestion had a high burden of clinical events during the index hospitalization (7.6% intensive care unit transfer, 2.1% intubation, 1.7% left ventricular assist device implantation, and 0.8% dialysis). At 90‐day follow‐up, 33% of patients were readmitted for ADHF or died. Outcomes and costs were similar between patients with reduced and preserved LVEF.ConclusionsMany patients admitted with ADHF have WRF and persistent congestion despite diuresis and are at high risk for adverse events during hospitalization and early follow‐up. Novel treatment strategies are urgently needed for this high‐risk population.
Angiotensin I‐converting enzyme type 2 expression is increased in pancreatic islets of type 2 diabetic donors
Authors: Fignani Daniela , Pedace Erika , Licata Giada , Grieco Giuseppina Emanuela , Aiello Elena , de Luca Carmela , Marselli Lorella , Marchetti Piero , Sebastiani Guido , Dotta Francesco 
Published: July 2023

AbstractAimsAngiotensin I‐converting enzyme type 2 (ACE2), a pivotal SARS‐CoV‐2 receptor, has been shown to be expressed in multiple cells, including human pancreatic beta‐cells. A putative bidirectional relationship between SARS‐CoV‐2 infection and diabetes has been suggested, confirming the hypothesis that viral infection in beta‐cells may lead to new‐onset diabetes or worse glycometabolic control in diabetic patients. However, whether ACE2 expression levels are altered in beta‐cells of diabetic patients has not yet been investigated. Here, we aimed to elucidate the in situ expression pattern of ACE2 in Type 2 diabetes (T2D) with respect to non‐diabetic donors which may account for a higher susceptibility to SARS‐CoV‐2 infection in beta‐cells.Material and MethodsAngiotensin I‐converting enzyme type 2 immunofluorescence analysis using two antibodies alongside insulin staining was performed on formalin‐fixed paraffin embedded pancreatic sections obtained from n = 20 T2D and n = 20 non‐diabetic (ND) multiorgan donors. Intensity and colocalisation analyses were performed on a total of 1082 pancreatic islets. Macrophage detection was performed using anti‐CD68 immunohistochemistry on serial sections from the same donors.ResultsUsing two different antibodies, ACE2 expression was confirmed in beta‐cells and in pancreas microvasculature. Angiotensin I‐converting enzyme type 2 expression was increased in pancreatic islets of T2D donors in comparison to ND controls alongside with a higher colocalisation rate between ACE2 and insulin using both anti‐ACE2 antibodies. CD68+ cells tended to be increased in T2D pancreata, in line with higher ACE2 expression observed in serial sections.ConclusionsHigher ACE2 expression in T2D islets might increase their susceptibility to SARS‐CoV‐2 infection during COVID‐19 in T2D patients, thus worsening glycometabolic outcomes and disease severity.