bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare case of endo-bronchial lipoma presenting with vague cardiac symptoms
Authors: Asghar Zoha , Irfani Muhammad Mehdi , Fatimi Alizeh , Sohail Abdul Ahad , Fatimi Saulat Hasnain 
Published: January 2025

Abstract
Endobronchial lipoma is an extremely rare benign tumor, accounting for 0.1%–0.5% of all lung tumors. This case report presents a patient diagnosed with endobronchial lipoma, a condition that can lead to significant bronchial obstruction and subsequent parenchymal damage. Patients usually exhibit symptoms including cough, dyspnea, and recurrent respiratory infections, which initially mimic more common pulmonary conditions such as chronic obstructive pulmonary disease. However, in our case patient presented with non-specific cardiac symptoms. Diagnosis was confirmed through bronchoscopy, revealing a well-circumscribed mass obstructing the bronchus. Due to severe parenchymal inflammation, treatment involved left-sided thoracotomy and upper lobectomy which successfully relieved the obstruction and alleviated the patient’s symptoms. Histopathological examination identified the tumor as a lipoma. This case underscores the importance of considering endobronchial lipoma in differential diagnoses for patients with unexplained cardiac or respiratory symptoms, as early detection and treatment can prevent significant complications.
Impersonal experiential constructions in ancient Northwest Semitic languages in a diachronic perspective
Authors: Notarius Tania 
Published: January 2025

Abstract
This paper scrutinizes the impersonal usage of experiential constructions in ancient Northwest Semitic (NWS) languages. A methodological distinction is made between affective and evaluative types of the impersonal experiential usage, where the affective type communicates the physical and emotive condition of the Experiencer (Hebrew ḥam lô ‘he feels warm’), and the evaluative type communicates an attitude towards particular proposition (Hebrew ˀim ˁal PN ṭôḇ ‘if PN would like …’). These types are distributed differently in the ancient NWS languages. The Old Canaanite of El-Amarna demonstrates both usages of the impersonal experiential construction, while Akkadian has only the evaluative usage. Ugaritic avoids the impersonal usage, except for some diagnostic cases in the language of prose. Biblical Hebrew consistently demonstrates both types. Official Aramaic exemplifies the evalua tive type only, while the affective type emerges at the Middle and Late Aramaic stages. In this paper, it is hypothesized that the impersonal experiential construction, and its affective type in particular, may be an areal Canaanite feature. The affective experiential usage appears in Ugaritic and then a thousand years later in Aramaic, as a result of contact with Canaanite languages.
Descriptive complexity for distributed computing with circuits
Authors: Ahvonen Veeti , Heiman Damian , Hella Lauri , Kuusisto Antti 
Published: January 2025

Abstract
We investigate distributed computing with identifiers in the realistic scenario where the local computations in a distributed message passing setting are operated by Boolean circuits. We call this framework the message passing circuit model. We capture the expressive power of the model with a recursive rule-based logic called modal substitution calculus MSC. The result is established via constructing translations that are highly efficient in relation to size and computation time. In particular, the worst size blow-up is quadratic and becomes linear in the bounded-degree scenario. Computation time delays are similarly modest. As a concrete demonstration of how our setting works, we establish that a very fast coloring algorithm based on Cole–Vishkin can be specified by logarithmic size programs (and thus also logarithmic size circuits) in the bounded-degree scenario.
Discovery of 26 new Galactic radio transients by MeerTRAP
Authors: Turner J D , Stappers B W , Tian J , Bezuidenhout M C , Caleb M , Driessen L N , Jankowski F , Pastor-Marazuela I , Rajwade K M , Surnis M , Kramer M , Barr E D , Berezina M 
Published: January 2025

Abstract
Radio searches for single pulses provide the opportunity to discover one-off events, fast transients and some pulsars that might otherwise be missed by conventional periodicity searches. The MeerTRAP real-time search pipeline operates commensally to observations with the MeerKAT telescope. Here, we report on 26 new Galactic radio transients, mostly rotating radio transients (RRATs) and also the detection of one RRAT and two pulsars that were independently discovered by other surveys. The dispersion measures of two of the new sources marginally exceed the Galactic contribution depending on the electron density model used. Using a simple method of fitting a Gaussian function to individual pulses, and obtaining positions of arcsecond accuracy from image-based localisations using channelised voltage data from our transient buffer, we have derived timing solutions spanning multiple years for five sources. The timing parameters imply ages of several Myr and low surface magnetic field strengths which is characteristic of RRATs. We were able to measure spin periods for eight more transients, including one source which appears to rotate every 17.5 seconds. A majority of the sources have only been seen in one observation, sometimes despite multiple return visits to the field. Some sources exhibit complex emission features like component switching and periodic microstructure.
The Racialized Sexism of Migration and Asylum Regimes Pregnancy, Migration, and Borders in France
Authors: Freedman Jane , Sahraoui Nina , Tyszler Elsa 
Published: January 2025

Abstract
The gendered implications of migration and asylum regimes require further attention in an era of border militarization and increasingly hostile environments, especially across the Global North, a region in which many countries pride themselves on standing for gender equality, whereas they in fact perpetuate gendered forms of discrimination and violence against irregularized migrant women. This article examines the experiences in France of pregnant women and recent mothers from Global South countries and their encounters with the asylum and migration regimes and the healthcare sector. We argue that the administrative precarity and material destitution that contemporary asylum and migration policies enact need to be analyzed as racialized sexism because of their specifically gendered implications as well as their racist premises. This research stems from fieldwork carried out in France in 2020 and 2021 in the capital, as well as at the “air borders” and at the French–Italian border in the Alps.
Climate friendly MOFs synthesis for drug delivery systems by integrating AI, intelligent manufacturing, and quantum solutions in industry 6.0 sustainable approach
Authors: Akhtar Maryam , Majeed Hammad , Iftikhar Tehreema , Ahmad Khalil 
Published: January 2025

Abstract
Since the Industrial Revolution, ecological damage, ecosystem disruption, and climate change acceleration have frequently resulted from human advancement at the price of the environment. Due to the rise in illnesses, Industry 6.0 calls for a renewed dedication to sustainability with latest technologies. Focused research and creative solutions are needed to achieve the UN Sustainable Development Goals (SDGs), especially 3, 9, 13, 14, 15, 17. A promising sustainable technology for enhancing healthcare while reducing environmental effect is Metal Organic Frameworks (MOFs). MOFs are perfect for drug administration because of their high surface areas, adjustable pore sizes, and remarkable drug-loading capacities. They are created by combining advanced artificial intelligence, intelligent manufacturing, and quantum computing. Researchers can create MOFs with functional groups or ligands that bind selectively to target cells or tissues, minimizing off-target effects, thanks to the distinct benefits that families like MIL, HKUST, UiO, and ZIF etc. offer for targeted drug delivery. Combining MOFs with other nanomaterials results in multipurpose systems that can handle challenging biomedical issues. Despite its promise, there are still issues with MOFs’ possible toxicity and long-term stability in physiological settings. To advance their medicinal applications, these problems must be resolved. Researchers can increase the usefulness of MOFs in medicine by critically analysing these limitations and putting up creative alternatives. The creation of MOFs especially with advanced technologies (additive manufacturing etc.) for drug delivery is a prime example of how scientific advancement and environmental stewardship may coexist to provide healthcare solutions that are advantageous to both people and the environment.
Enhancement of adipose stem cell quality via Cu‐MON: Transcriptome and bioinformatics analysis of normal and diabetic stem cells
Authors: Pang Ruixin , Liu Kaijing , Liu Biou , Yang Jing 
Published: January 2025

AbstractTransplanted adipose stem cells (ASC) have a low survival rate in the body, and there are not many ASC that can be effectively used, which weakens their tissue repair function. Based on this status quo, a new type of copper‐based metal–organic network (Cu‐MON) was used to pretreat cells to regulate cell activity in order to improve the efficacy of cell therapy or reduce the number of cells used, thus reducing the cost of clinical treatment. Gene expression changes before and after Cu‐MON treatment of normal donor adipose stem cells (ND‐ASC) and type 2 diabetes mellitus adipose stem cells (T2DM‐ASC) were evaluated through RNA sequencing, KEGG and GO enrichment analysis. The results showed that Cu‐MON improved ASC cell quality by regulating immune response and promoting paracrine secretion. IL‐17 signaling pathway and IL‐6, CXCL8, and MMP‐9 were key pathways and necessary genes that affected the ability of stem cells. In addition, Cu‐MON also improved stem cell antiviral ability through Type I interferon signaling pathway. Our research showed that Cu‐MON had improved the cell quality of ASC by regulating immune response, promoting paracrine secretion, and improving antiviral capabilities. This approach to biomaterial pretreatment is fast, convenient, and relatively safe, and provides new strategies for improving the efficiency of cell therapies.
Sodium tanshinone IIA sulfonate alleviates fetal growth restriction by mediating aquaporin‐3 expression in placental trophoblast cells
Authors: Pan Shuangjia , Xu Anjian , Chen Baoyi , Lu Xinyue , Zou Jieni , Hua Ying 
Published: January 2025

AbstractFetal growth restriction (FGR) is characterized by the inability of the fetus to achieve its growth potential due to pathological factors, most commonly impaired placental trophoblast cell function. Currently, effective prevention and treatment methods of FGR are limited. We aimed to explore the pathogenesis of FGR and provide potential strategies for mitigating its occurrence. The case–control study compared AQP3 expression in placental trophoblast cells of pregnant women with FGR and those with normal pregnancies. Then mouse FGR models were induced via cadmium exposure, and placental trophoblast cells (JEG‐3) were similarly treated. The study assessed the effects of Sodium tanshinone IIA sulfonate (STS) and the role of the PI3K/Akt pathway in improving AQP3 expression and trophoblast cell function. Placental trophoblast cells in FGR cases exhibited significantly reduced AQP3 expression. AQP3‐knockdown cells displayed dysfunction. Cadmium exposure in mice and JEG‐3 cells led to decreased AQP3 expression and trophoblast cell dysfunction, both of which were ameliorated by STS. Fetal mouse weight increased with STS treatment. STS upregulated AQP3 expression and improved trophoblast cell function in AQP3‐knockdown cells. Inhibiting the PI3K/Akt pathway diminished STS's beneficial effects. ThereforeSTS may enhance AQP3 expression in placental trophoblast cells affected by FGR through the activation of the PI3K/Akt pathway, ultimately bolstering placental trophoblast cell function and alleviating FGR. As above, STS appears to be a potential therapeutic agent for alleviating FGR.
Longitudinal T cell repertoire analysis reveals dynamic clonal T cell populations in Ulcerative Colitis
Authors: Briggs Kristi C. , Lin Jessica S. , Chaaban Lara , Parian Alyssa , Lazarev Mark , Selaru Florin , Housseau Franck , Smith Kellie N. , Melia Joanna M. P. 
Published: January 2025

ABSTRACTBackgroundUlcerative Colitis (UC) is characterized by chronic, relapsing and remitting inflammation in the colon and rectum. Pathogenic T cell activity is thought to play a major role in this process. T cell effector function is determined by the T cell receptor (TCR) and the antigen it recognizes. Examining the TCR repertoire can provide key insights into the adaptive immune response.ObjectiveTo characterize the longitudinal TCR repertoire of patients with UC across disease activity to determine if recurrent antigen(s) are responsible for active inflammation.DesignBulk TCR Vβ sequencing was done on colon tissue of 20 patients with UC across multiple time points of disease. Corresponding clinical metadata was also obtained over the same time period for each patient to map their clinical disease course. The top ten most highly abundant clones from each time point were longitudinally tracked and correlated with disease phenotype.ResultsSeventy-five percent of patients did not have overlapping abundant TCR clones across multiple time points of disease. The remaining 25% of patients had one to five TCR clones present in high abundance in their tissue during every time point analyzed.ConclusionThese results demonstrate that most patients with UC do not share a similar TCR repertoire over time, indicating that times of inflammation are associated with unique antigen exposures. A smaller group of patients have persistent, private TCR clones with high abundance, 60% of whom had more unremitting, active disease.
Matrix stiffness modulated release of spheroid-derived extracellular vesicles and discovery of Piezo1 cargo
Authors: Sheth Maulee , Sharma Manju , Kongsomros Supasek , Lehn Maria , Takebe Takanori , Takiar Vinita , Wise-Draper Trisha , Chutipongtanate Somchai , Esfandiari Leyla 
Published: January 2025

AbstractAugmented extracellular matrix (ECM) stiffness is a mechanical hallmark of cancer. Mechanotransduction studies have extensively probed the mechanisms by which ECM stiffness regulates intracellular communication. However, the influence of stiffness on intercellular communication aiding tumor progression in three-dimensional microenvironments remains unknown. Small extracellular vesicles (EVs) are communicators of altered biophysical cues to distant sites through EV-ECM interactions and EV-mediated recipient cell-ECM interactions. Here we demonstrate stiffness-mediated modulation of small EVs secretion and cargo from three-dimensional oral squamous cell carcinoma spheroids. Using a spheroid culture platform with varying matrix stiffness properties, we show that small EVs carry parental biomolecular cargo, including mechanosensitive Piezo1 ion channel and adhesion molecule CD44. We comprehensively validate the presence of both markers in our EV populations using proteomic and genetic analysis. Transcriptomic analysis of microRNA and long non-coding RNA cargo of small EVs released from soft and stiff ECM spheroids revealed enrichment of tumorigenic and metastatic profiles in EVs from stiff ECM cultures compared to that of soft ones. Gene set enrichment analysis of a comparative dataset obtained by overlaying spheroid mRNA and EV miRNA profiles identified key oncogenic pathways involved in cell-EV crosstalk in the spheroid model.
The Dark Side of Photosymbiosis: Elaborate Repeats with TEs and Unknown ORFs in Photosymbiotic Bivalves Made Exceptionally Big Metazoan Mitogenomes
Authors: Tan Andy D. Y. , Li Ruiqi , Li Jingchun 
Published: January 2025

ABSTRACTLimited truly “complete”mitogenomes have been published for marine invertebrates, with many being partial and focused on protein-coding genes. Dispelling the traditional myth of “metazoan mitogenomes being highly conserved in size and gene order”, long-read technologies have revealed novel structures and complexities in animal mitogenomes. Our investigation of PacBio-assembled mitogenomes of several marine bivalve species (family Cardiidae), revealed a photosymbiotic bivalve,Fragum sueziense, possesses one of the largest circular metazoan mitogenome (92,770 bp). Additionally, mitogenomes of photosymbiotic bivalves from the generaFragumandTridacnaranged from 22 to 92.8 kb, surpassing the more typical sizes in non-photosymbiotic cardiids (∼14 to 19 kb). Those expansions in mitogenomes are attributed to elaborate, species-specific repetitive sequences in the major non-coding region (NCR) which manifest an inability to assemble “complete” mitogenomes from Illumina short reads (at 150 bp) alone; divergent nature of those NCRs also hinder interspecies alignment. However, we annotated supernumerary tRNAs, transposable element fragments and open reading frames in NCRs despite their hitherto unknown functions. We postulate that NCR inflation in these photosymbiotic species may be associated with elevated reactive oxygen species in their mantle and altered immune states due to host-symbiont interactions involving photosymbionts. More complete mitogenomes are needed to uncover novel genetic elements and their functions otherwise undocumented to science.SIGNIFICANCE STATEMENTMany published animal mitogenomes does not truly span the entirety of the major non-coding region (NCR), often due to the inability of short-read sequencing to confidently cover highly repetitive sequences. In this study, long-read sequencing enabled us to access “more complete” mitogenomes for a comparative analysis focused on the nature of the NCRs between photosymbiotic and non-photosymbiotic bivalves, and the elements within them. We not only uncovered one of the largest circular metazoan mitogenomes (Fragum sueziense), but also found ample genetic elements within the conventionally “non-coding” regions, including extensive elaborate repeat patterns, transposable elements and unknown open reading frames. To our knowledge, this is the first time extensive transposable elements have been reported in animal mitogenomes. Our study revealed extreme mitogenome expansions and complexities as potential costs to bivalve-algal photosymbiosis, and provide insights into metazoan symbiosis evolution.
What is the best brain state to predict autistic traits?
Authors: Horien Corey , Mandino Francesca , Greene Abigail S. , Shen Xilin , Powell Kelly , Vernetti Angelina , O’Connor David , McPartland James C. , Volkmar Fred R. , Chun Marvin , Chawarska Katarzyna , Lake Evelyn M.R. , Rosenberg Monica D. , Satterthwaite Theodore , Scheinost Dustin , Finn Emily , Constable R. Todd 
Published: January 2025

AbstractAutism is a heterogeneous condition, and functional magnetic resonance imaging-based studies have advanced understanding of neurobiological correlates of autistic features. Nevertheless, little work has focused on the optimal brain states to reveal brain-phenotype relationships. In addition, there is a need to better understand the relevance of attentional abilities in mediating autistic features. Using connectome-based predictive modelling, we interrogate three datasets to determine scanning conditions that can boost prediction of clinically relevant phenotypes and assess generalizability. In dataset one, a sample of youth with autism and neurotypical participants, we find that a sustained attention task (the gradual onset continuous performance task) results in high prediction performance of autistic traits compared to a free-viewing social attention task and a resting-state condition. In dataset two, we observe the predictive network model of autistic traits generated from the sustained attention task generalizes to predict measures of attention in neurotypical adults. In dataset three, we show the same predictive network model of autistic traits from dataset one further generalizes to predict measures of social responsiveness in data from the Autism Brain Imaging Data Exchange. In sum, our data suggest that an in-scanner sustained attention challenge can help delineate robust markers of autistic traits and support the continued investigation of the optimal brain states under which to predict phenotypes in psychiatric conditions.
Rehabilitation your way: A randomized trial comparing home-based and self-managed web versus paper programs to improve arm and hand function after stroke
Authors: Westlake Kelly P. , Waller Sandy McCombe , Magdar Lawrence , Akinsolotu Ruth , Udo Jean , Burridge Jane , Whitall Jill 
Published: January 2025

ABSTRACTBackgroundHome-based, self-managed stroke rehabilitation can complement limited healthcare resources. Computer-based programs offer a potential for rehabilitation without the need for complex technology or direct therapist supervision.ObjectiveTo compare effectiveness of a home-based web rehabilitation program (STRONG) versus a paper exercise program (PEP) for stroke-related upper extremity disability.MethodsIn this single-blind randomized controlled trial 43 participants with stroke were stratified by motor ability and motivation, then randomly assigned to either STRONG (n=22) or PEP (n=21). Training consisted of a 6-week intervention phase (at least 1 hour daily, 5 days weekly), followed by a 6-week follow-up phase with optional training. Primary outcomes were Fugl-Meyer Upper Extremity Assessment (FMA) and the streamlined timed Wolf Motor Function Test (WMFT-T). Secondary outcomes Motor Activity Log (MAL), WMFT-Function (WMFT-F), Stroke Motivation Scale, and Self-Efficacy Scale.ResultsNeither program showed superiority in FMA or WMFT-T. Within-group FMA improvements were similar (Strong: 1.8 points vs PEP: 2.1 points at post-training; 3.3 vs 1.9 at follow-up). However, STRONG participants reported better arm and hand use in daily activities (MAL) at post-training and follow-up. Additionally, STRONG participants showed higher self-efficacy at post-training, though this difference was not maintained at follow-up.ConclusionBoth programs led to modest motor improvements. While STRONG did not outperform PEP in the primary outcomes, participants reported using their affected arm and hand more in daily activities and higher program continuation after the intervention period. Results suggest that home-based, self-managed rehabilitation combining exercises with daily tasks appears beneficial for stroke survivors post-standard rehabilitation.Clinicaltrials.govidentifier:NCT03484182