bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hesperetin effect on MLH1 and MSH2 expression on breast cancer cells BT-549
Authors: Hasan Assim Khattab , Babaei Esmaeil , Al-Khafaji Ahmed Salim Kadhim 
Published: August 2023

ABSTRACT
Due to its genetic and phenotypic heterogeneity, breast cancer is very difficult to eliminate. The harmful consequences of conventional therapies like radiation and chemotherapy have prompted the search for organic-based alternatives. Hesperetin (HSP), a flavonoid, has been discovered to possess the ability to hinder the proliferation of cell associated with breast cancer by acting as an epigenetic agent and modifying gene expression. In this investigation, breast cancer cells (BT-549) and normal cells (MCF-10a) were subjected to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test and three different doses (200, 400, and 600 μM/mL) of HSP for real-time polymerase chain reaction and flow cytometry to examine its cytotoxic and anti-malignant potential. HSP was shown to be cytotoxic to both normal and breast cancer cells, but had a more pronounced effect on the cancer cell lines. After 48 h of treatment, the half-maximal inhibitory concentration (IC50) for BT-549 was 279.2 μM/mL, whereas the IC50 for MCF-10a was 855.4 μM/mL. At high HSP concentrations, upregulation of the MLH1 and MSH2 genes was observed in both cell lines. The influence of HSP on MLH1 gene expression was concentration dependent. Moreover, HSP had a concentration-dependent effect on MSH2 gene expression in the BT-549 cell line but not in the MCF-10a cell line. Cell death and early apoptosis were shown to be concentration dependent upon the application of HSP, as determined by flow cytometric analysis. HSP’s capacity to cause apoptosis and its stronger impact on the malignant cell line when analyzed with the normal cell line imply that it might be useful as an effective therapeutic approach for combating breast cancer.
Development of a spectrophotometric analytical approach for the measurement of cefdinir in various pharmaceuticals
Authors: Mahmood Ali Khalil , Sallal Takleef Dheyab , Al-Janabi Khalid Waleed S. , Luaibi Hasan Mohammed 
Published: August 2023

ABSTRACT
An accurate and sensitive determination procedure has been established for the quantification of cefdinir in pure and pharmacological formulas. The approach was dependent on derivatizing cefdinir with sodium anthraquinone-2-sulfonate (SAS) in an alkaline medium to produce a magenta-colored derivative with a maximum absorbance at 517 nm against the reagent blank. Different factors affecting the interaction of cefdinir with SAS were studied carefully and optimized, such as the buffer value, medium acidity, the duration of hydrolysis, and the reagent percentage. Under optimized conditions, a linear calibration curve with a correlation coefficient of R
2 = 0.9995 was obtained over the concentration range of cefdinir 0.5–100 μg/mL. The values of the parameters that represented the sensitivity of the method were satisfactory, i.e., the limit of detection, the limit of quantification, as well as Sandell’s sensitivity (л) were 0.1 μg/mL, 0.5 μg/mL, and 0.064 μg/cm2/0.001 Au, respectively. The relative standard deviation was below 1.35%, while the percentage recovery was 99.930%–102.257%. The mole ratio of the colored complex was estimated by following Job’s method of continuous variation, which indicated that the cefdinir-SAS ratio was 1:1. The suggested approach was proven to be adequately accurate, precise, and without interfering with common excipients and additives. Thus, it could be implemented successfully for the standard determination of cefdinir in its pure and pharmaceutical forms.
An educational intervention to improve health and nutrition literacy in hypertensive patients in Greece
Authors: Mourouti Niki , Michou Maria , Lionis Christos , Kalagia Panagiota , Ioannidis Angelos G. , Kaloidas Michalis , Costarelli Vassiliki 
Published: August 2023

BACKGROUND:
Suboptimal control of blood pressure (BP) is a public health challenge in Greece. This educational intervention attempts to improve health literacy (HL) and nutrition literacy (NL) in primary healthcare (PHC) patients with hypertension (HTN).

MATERIALS AND METHODS:
This was a proof-of-concept (PoC) educational intervention. Twenty-four patients with HTN and low or medium levels of HL agreed to participate in this 6-week educational intervention. The program was delivered by a general practitioner (GP) in group A and by a qualified nurse in group B. Group C was the control group. The levels of HL of NL, adherence to the Mediterranean diet, and perceived stress were assessed using the European Health Literacy Survey Questionnaire 16 (HLS_EU_Q16) and part B (reading a medication label) of the High Blood Pressure–Health Literacy Scale (HBP–HLS), the Nutrition Literacy Scale-Greek (NLS-Gr), the Mediterranean Diet Adherence Screener (MEDAS), and the Perceived Stress Scale (PSS-14), respectively, together with certain socioeconomic, dietary, and lifestyle characteristics. The Kruskal–Wallis and Wilcoxon nonparametric, the Chi-square, and the McNemar–Bowker tests were used. The analysis was done with the STATA software, version 14 (MP & Associates, Sparta, Greece).

RESULTS:
No statistically significant differences were found in the total score of HL and NL before and after the intervention; however, the results indicate a slight improvement in HL and NL levels in the two intervention groups, together with small improvements in knowledge and behaviors related to HTN and dietary salt. A trend of improvement in the MEDAS levels in the GP's group and the HBP–HLS levels in the nurse's group was also reported.

CONCLUSION:
A slight improvement in HL and NL levels in the two intervention groups has been reported, and the changes, however, were not statistically significant.
Predictive factors of disordered eating among adolescents in Bosnia and Herzegovina
Authors: Ćorić Martina Krešić , Graovac Mirjana , Pravdić Nikolina , Raguž Ana Boban , Kaštelan Ana 
Published: August 2023

BACKGROUND:
Due to excessive concerns and focus on weight control and body shape, adolescents often resort to inappropriate behaviours and attitudes towards eating, resulting in physical and psychological issues. This study aimed to assess possible relationships and predictor variables between disordered eating and age, BMI, body appreciation, self-esteem, quality of family interactions, psychosocial health and childhood trauma experience in adolescents of both sexes in the city of Mostar (Bosnia and Herzegovina).

MATERIALS AND METHODS:
A cross-sectional study was carried out on a suitable sample of 724 high-school students aged 14-19 years. The following tools have been used: socio-demographic questionnaire, The Eating Attitudes Test (EAT-26), Body Mass Index (BMI), Body Appreciation Scale (BAS), Rosenberg's Self-Esteem Scale, Quality of Family Interaction Scale (KOBI), and Paediatric Quality of Life Inventory, version 4.0 (PedsQLTM) and Childhood trauma Questionnaire (CTQ). Collected data were analyzed in SPSS v. 20.0 software using Pearson's correlation coefficient and multiple regression analysis.

RESULTS:
Body appreciation is the most significant predictor for developing disordered eating across the entire sample of adolescents (β = -0.325, P < 0.05) and individually for male adolescents (β = -0.199, P = 0.010) and female adolescents (β = -0.379, P < 0.001). In addition to this variable, BMI has proved to be a statistically significant predictor in explaining the eating behaviours of female adolescents (β = 0.185, P < 0.001), while this happens to be self-esteem for male adolescents (β = -0.211, P < 0.022).

CONCLUSION:
The most significant risk factors for developing disordered eating in adolescents are body appreciation, BMI and self-esteem. Results of this research can contribute to enhancement of intervention programmes which promote a positive body image and aim to prevent disordered eating in adolescents of both sexes.
A national level survey on knowledge, attitude and practices among Indian nurses on viral hepatitis
Authors: George Mini , Sharma Tarika , Ahwal Sarita , Rastogi Aayushi , Bansal Akanksha 
Published: August 2023

BACKGROUND:
Despite being preventable and treatable, viral hepatitis remains a major public health problem in India. In the line of their duties, nursing professionals are constantly at risk of infection. To combat viral hepatitis, it is essential to ascertain the level of knowledge, attitude, and practices among nursing professionals.

MATERIALS AND METHODS:
A descriptive cross-section study was conducted at a tertiary public hospital, as a nation-wide online survey after ethical clearance and participants' consent. A convenience sampling, from November 2021 to September 2022, yielded a total of 4532 nurses, nursing students and educators. A self-administered 62-item questionnaire on viral hepatitis with four sections: demographic details, knowledge (33-items), attitude (5-items), and practice (24-itmes) was prepared by expert panel and had a content validity and reliability >0.8. The scale was compiled onto the SurveyMonkey app, field tested before administration and widely circulated on email.

RESULT:
The response rate of the survey was 77%. Frequency, percentage, and the odds ratio (at 95% confidence interval) were analyzed on SPSS v22.0. Majority were females (87.1%) aged <30 years (60%) with <5 years' experience (57.8%). Almost equal number worked in public or private sector and was holders of diploma (44.5%) or degree (43.8%). Overall poor knowledge (85.3%), unfavorable attitude (86.2%), and unsafe practices (55.6%) were exhibited by nurses; 42.2% encountered needle stick injury last year and 49.8% had never checked Anti-HBs titer. In the event of needle stick injury, 74.78% cleansed with soap and water; used antiseptics or washes (33.5%), placed finger in mouth (5.10%), forced wound bleed (17.3%), scrub wound (17.54%), or apply bandage (12.58%). Multivariate analysis of factors influencing knowledge of viral hepatitis was educational qualification, designation, and type of health facility.

CONCLUSION:
As nursing professionals are constantly at risk, there is an urgent need to raise awareness about hepatitis, the post-exposure prophylaxis and vaccination status. Every healthcare facility should include training and capacity building for nurses about risk, prevention, transmission, and management of viral hepatitis, as an integral part of orientation and continuing education on-the-job; follow stringent policies; and set-up mechanisms for monitoring and follow up. Further, policymakers and statutory bodies need to ensure the standards of nursing practice and improve the health of nurses and their patients.
Effectiveness of McKenzie approach and segmental spinal stabilization exercises on neck pain in individuals with cervical postural syndrome: An experimental study
Authors: Avaghade Rutuja R. , Shinde Sandeep B. , Dhane Sayalee B. 
Published: August 2023

BACKGROUND:
This study “Effectiveness of Mckenzie approach and segmental spinal stabilization exercises on neck pain in individuals with cervical postural syndrome: an experimental study” was conducted to study and find the effectiveness of Mckenzie approach and segmental spinal stabilization exercises on reduction of pain, correction of rounded shoulder, and disability. Pain, disability, and rounded shoulders are the major limiting factors as it affects the quality of life and reduces efficiency and social participation.

MATERIALS AND METHODS:
The study was conducted among 120 individuals with cervical postural syndrome, and fulfilling the inclusion and exclusion criteria was included. The outcome measures were Visual Analogue Scale (VAS), Neck Disability Index (NDI), and Vernier caliper to evaluate pain, functional disability, and rounded shoulder, respectively. Subjects were randomly divided into two groups, Group A and Group B, by using SPSS software. Interventional training was given for 6 weeks to the patients. Group A subjects were given spinal stabilization exercises. Group B subjects were given Mckenzie approach. The statistical analysis was performed using SPSS; pre-test and post-test were used to calculate the results, followed by data presentation and analysis.

RESULT:
The result showed that at the end of the 6 weeks on comparison between pre- and post-intervention of Group A and Group B, both the techniques were effective, but group B was significantly effective than Group A.

CONCLUSION:
It was noted that McKenzie approach and segmental spinal stabilization exercises were effective on neck pain in individuals with cervical postural syndrome, but on comparing both techniques, Mckenzie protocol is more beneficial than segmental spinal stabilization exercises. The study accepts the alternate hypothesis that there is significant effect of McKenzie approach and segmental spinal stabilization exercises on neck pain in individuals with cervical postural syndrome.
Effect of life skills education on socio-emotional functioning of adolescents in urban Puducherry, India: A mixed-methods study
Authors: Surendran Gayathri , Sarkar Sonali , Kandasamy Preeti , Rehman Tanveer , Eliyas Salin , Sakthivel Manikandanesan 
Published: August 2023

BACKGROUND:
We wanted to assess the effect of life skills education (LSE) and regular curriculum on the self-esteem, self-efficacy, adjustment, and psychosocial functioning of students from co-educational government schools, compared to those receiving only the regular curriculum. The secondary objectives were to study the feasibility of such sessions and identify the factors affecting the effectiveness of the sessions.

MATERIALS AND METHODS:
We conducted a mixed-methods study in government schools of urban Puducherry, India in 2018–2019. The quantitative component was a cluster-randomized trial with activity-based learning methods delivered over 10 sessions in the intervention arm (IA). Differences in outcome variables (self-esteem, self-efficacy, adjustment, psychosocial behavior) between baseline and after intervention in each of the groups were calculated, and the difference-in-differences (DID) technique was applied to account for any natural change in scores over time. Qualitative data were collected through focused group discussions (FGDs) among students and teachers. Analysis was founded on a positivist paradigm with inducto-deductive methodology.

RESULTS:
The mean (SD) age of 258 participants was 13 (1) years in both arms. The mean (SD) difference between baseline and end-line for IA and control arm (CA) was 0.3 (4.4) and − 0.1 (4.0), for self-esteem (P = 0.38), 0.03 (6.0) and − 1.1 (6.1) for self-efficacy (P = 0.12), and − 0.04 (3.5) and − 0.05 (4.3) for adjustment (P = 0.73), respectively. Similarly, the median (interquartile range [IQR]) difference in the conduct problems scale of the Strengths and Difficulties Questionnaire was − 1 (−2, 1) and 0 (−1, 1) (P < 0.01). Five FGDs revealed multiple positive effects on anger management, conduct, self-awareness, and responsible behavior. All 10 teachers viewed life skills education (LSE) positively.

CONCLUSIONS:
LSE positively affects adolescents' socio-emotional functioning, but more extended periods of exposure are needed to demonstrate discernible change. The feasibility of implementation depends on the syllabus and based on health policies.
A comparative study: Accreditation of universities' disaster risk management for health promotion
Authors: Miresmaeeli Seyedeh Samaneh , Zavareh Davoud Khorasani , Seyedin Hesam 
Published: August 2023

BACKGROUND:
Risk management processes accreditation in emergencies and disasters can determine the effectiveness and efficiency of these processes. Universities, as the highest level of education, should provide a safe environment for educational services and activities of these people.

AIMS:
The present study aimed to review and compare different accreditation models for emergencies and disaster risk management in selected countries. Reaching other accreditation models together and identifying their similarities and differences, along with considering the implementation of each model, can significantly help the countries which aim to design and develop a risk management accreditation model or upgrade their models.

MATERIALS AND METHODS:
In this qualitative comparative study, the US, UK, Canada, Australia, Japan, and South Africa were selected based on research criteria. A literature review compared university emergency and disaster risk management accreditation models. The obtained data were collected in a researcher-made matrix, and a content analysis method was used for data analysis. Differences and similarities of selected countries in the fields of accreditation program(s), accreditation institute, start year, obligation, accredited organizations, number of criteria, criteria titles, accreditation focus, accreditation stages, number of stages, scoring method, and ranking method were compared.

RESULT:
Designing a local model for the accreditation of disaster risk management in universities based on the crisis management system in each country can lead to improving the level of responsiveness and quality of services in emergency situations and health promotion.
Comparing the self-awareness and problem-solving skills training on sexual desire of newly married women: A field trial study
Authors: Moodi Saba , Mehrbakhsh Zahra , Amtaeh Fatemeh , Moghasemi Sedigheh 
Published: August 2023

BACKGROUND:
Sexual desire of women is one of the most important factors affecting marital and sexual satisfaction. Regarding the association of life skills level with sexual dissatisfaction and sexual desire, the present study aims to compare the effect of self-awareness and problem-solving skills training on the sexual desire of newly married women.

MATERIALS AND METHODS:
This was an experimental field trial study conducted since October 2019 to September 2020. The participants included 105 married women with a history of up to 5 years of cohabitation assigned randomly to either of the two intervention or control groups. The data collection tools include a demographic form, Hulbert index of sexual desire (HISD), and ENRICH couple scale that were completed by the participants before (T1), immediately (T2), and one month after the intervention (T3). The first intervention group received self-awareness skills training, whereas the second one received problem-solving skills training (four sessions of 90 min) weekly. On the other hand, the control group received no training. Statistical analyses were performed using SPSS 16 software and descriptive-analytical statistical tests including one-way ANOVA, Kruskal–Wallis, Bonferroni test, tests of within-subjects effects, and analysis test with repeated measures. P value < 0.05 was considered significant.

RESULTS:
The effect of time (statistic test: 51.24, P-value < 0.001) and the interaction effects of Time and Group on sexual desire (statistic test: 2.87, P-value: 0.03) were statistically significant. The mean score of sexual desire both in interventions and control groups showed statistically significant improvement. The mean score of sexual desire in the self-awareness group was 44.31 ± 9.08 (T1), 51.34 ± 10.92 (T2), and 59.48 ± 13.76 (T3) (P < 0.001); in the problem-solving group was 48.74 ± 10.21 (T1), 52.08 ± 10.59 (T2), and 57.40 ± 12.40 (T3) (P < 0.001); and in the control group was 47.74 ± 11.60 (T1), 50.08 ± 10.04 (T2), and 54.94 ± 12.15 (T3) (P = 0.02).

CONCLUSION:
The present study showed the effectiveness of both self-awareness and problem-solving skills training on newly married women's sexual desire. Moreover, this study showed simply participating in a study related to sexual desire as a control group could be effective on women's sexual desire.
A comparative study of interagency communications and information exchange in disaster response among selected countries
Authors: Abdolahzadeh Fayegh , Bagherian Hossein , Peyravi Mahmoudreza , Kolivand Pirhossein , Tavakoli Nahid 
Published: August 2023

BACKGROUND:
Effective communications and secure information exchange platforms during disasters and emergencies are among the significant factors in inclusive disaster management and can radically contribute to better preparedness, efficient and timely responsiveness, and, finally, maximal reduction of damages and fatalities. The present study was to compare communications and information exchange among disaster response organizations in selected countries.

MATERIALS AND METHOD:
This applied research, carried out in 2022, was a qualitative descriptive-comparative study pursuing a content analysis approach. Australia, Turkey, India, America, Japan, and Iran constituted the statistical population of the study. The sampling was based on the countries' disaster histories and response experiences. The note-taking tool was used to extract and collect data during the review of texts, documents, and articles, and the qualitative content analysis method was employed for data analysis.

RESULTS:
The outcomes of the descriptive-comparative analysis fell into four main comparative axes of the selected countries, including comparing reference, authority, and coordinator organizations in the response phase, comparing planning records and histories in disaster and emergency management comparing the contribution or non-contribution of government, military institutions, and non-governmental organizations to disaster and emergency management, the commonalities of the selected countries' disaster and emergency management and dependence on government.

CONCLUSION:
The results revealed that all selected countries depended on the government in managing disasters and emergencies, and the four communication platforms, i.e., landline telephone, mobile phone, radio communications systems, and couriers, were the common communication and information acquisition sources.
Coronavirus disease 2019 and distance learning in King Abdulaziz University
Authors: Karami Mohammed Matoog 
Published: August 2023

Background:
The shuttering of educational institutions in the Kingdom of Saudi Arabia due to the coronavirus disease 2019 (COVID-19) pandemic triggered an unforeseen abrupt transition from traditional in-person learning to an online learning environment.

Aims:
The aim of the present study is to assess how these changes impacted students at the College of Pharmacy (COP) of King Abdulaziz University (KAU) in Jeddah, Saudi Arabia.

Settings and Design:
The data for this study came from student performance measures and feedback on student experiences as they completed their required physiology course online through the COP at KAU during the COVID-19 lockdown.

Materials and Methods:
We E-mailed a questionnaire to all 1st year COP students (n = 137) registered in the 2019–2020 academic year. The questionnaire was available in both English and Arabic and included questions aimed at assessing student challenges and perception of the distance learning experience.

Statistical Analysis Used:
All statistical analyses were performed using GraphPad Prism 5 (GraphPad Software, CA, USA).

Results:
We obtained 118 responses. Among those, 77.8% preferred either face-to-face instruction or blended learning. The challenges to distance learning reported by the respondents' included issues related to the use of technology tools (61%). However, although only 39.8% felt that the COVID-19 pandemic raised their confidence in the efficacy of online education, the overall success rate was higher than before the pandemic.

Conclusion:
The pandemic-induced mandatory move to distance learning underscored the need to restructure and modify the curriculum to support virtual education, as well as the need for better facilities and telecommunication infrastructure to support online education.