bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for a randomized study assessing the feasibility of home-based albuminuria screening among the general population: The THOMAS study
Authors: van Mil Dominique , Kieneker Lyanne M. , Evers-Roeten Birgitte , Thelen Marc H. M. , de Vries Hanne , Hemmelder Marc H. , Dorgelo Annemiek , van Etten Ronald W. , Heerspink Hiddo J. L. , Gansevoort Ron T. 
Published: December 2022

Background
Chronic kidney disease (CKD) is a rising public health problem that may progress to kidney failure, requiring kidney replacement therapy. It is also associated with an increased incidence of cardiovascular disease (CVD). Because of its asymptomatic nature, CKD is often detected in a late stage. Population screening for albuminuria could allow early detection of people with CKD who may benefit from preventive treatment. In case such screening is performed in a general practitioner (GP) setting, this will result in relatively high costs. Home-based screening might be an effective and cost-effective alternative.

Aim
The THOMAS study (Towards HOMe-based Albuminuria Screening) is designed to prospectively investigate two methods for home-based population screening for increased albuminuria to detect yet undiagnosed CKD and risk factors for progression and CVD.

Methods
This investigator initiated, randomized population-based study will include 15.000 individuals aged 45–80 years, who will be randomly assigned to be invited for a home-based screening test for albuminuria with a more conventional urine collection device or an innovative smartphone application. If the test result is positive upon confirmation (i.e., elevated albuminuria), participants are invited to a central screening facility for an elaborate screening for CKD and CVD risk factors. Participants are referred to their GP for appropriate treatment, if abnormalities are found. Primary endpoints are the participation rate, yield, and cost-effectiveness of the home-based screening and elaborate screening.

Conclusions
The THOMAS study will evaluate the effectiveness and cost-effectiveness of home-based albuminuria screening in the general population for the early detection of CKD and CVD risk factors. It will provide insight into the willingness to participate in population screening for CKD and into the compliance of the general population to a corresponding screening protocol and compliance to participate. Thus, it may help to develop an attractive novel screening strategy for the early detection of CKD.

Trial registration
ClinicalTrials.gov, registration number NCT04295889, registered 05 March 2020. https://www.google.com/search?client=firefox-b-d&q=NCT04295889.
Prediction of hospital readmission of multimorbid patients using machine learning models
Authors: Le Lay Jules , Alfonso-Lizarazo Edgar , Augusto Vincent , Bongue Bienvenu , Masmoudi Malek , Xie Xiaolan , Gramont Baptiste , Célarier Thomas 
Published: December 2022

Objective
The objective of this study is twofold. First, we seek to understand the characteristics of the multimorbid population that needs hospital care by using all diagnoses information (ICD-10 codes) and two aggregated multimorbidity and frailty scores. Second, we use machine learning prediction models on these multimorbid patients characteristics to predict rehospitalization within 30 and 365 days and their length of stay.

Methods
This study was conducted on 8 882 anonymized patients hospitalized at the University Hospital of Saint-Étienne. A descriptive statistical analysis was performed to better understand the characteristics of the patient population. Multimorbidity was measured using raw diagnoses information and two specific scores based on clusters of diagnoses: the Hospital Frailty Risk Score and the Calderon-Larrañaga index. Based on these variables different machine learning models (Decision Tree, Random forest and k-nearest Neighbors) were used to predict near future rehospitalization and length of stay (LoS).

Results
The use of random forest algorithms yielded better performance to predict both 365 and 30 days rehospitalization and using the diagnoses ICD-10 codes directly was significantly more efficient. However, using the Calderon-Larrañaga’s clusters of diagnoses can be used as an efficient substitute for diagnoses information for predicting readmission. The predictive power of the algorithms is quite low on length of stay indicator.

Conclusion
Using machine learning techniques using patients’ diagnoses information and Calderon-Larrañaga’s score yielded efficient results to predict hospital readmission of multimorbid patients. These methods could help improve the management of care of multimorbid patients in hospitals.
Pattern and perceived changes in quality of life of Vietnamese medical and nursing students during the COVID-19 pandemic
Authors: Minh Le Dai , Phan Hoang Huy , Le Mai Duong Ngoc , Dat Nguyen Tien , Tri Ngo Minh , Ha Nguyen Viet , Tu Nguyen Huu , Foster Kirsty , Giang Kim Bao , Pham Tung Thanh 
Published: December 2022

Background
The COVID-19 pandemic and governments’ response lead to dramatical change in quality of life worldwide. However, the extent of this change in Vietnamese medical and nursing students has not been documented.

Objectives
The study aims to describe the quality of life and changes in quality of life of medical and nursing students during the COVID-19 pandemic and examine the association of quality of life and changes in quality of life with fear of COVID-19 and other socio-economic and demographic factors.

Methods
The study was a cross-sectional study on all students of Hanoi Medical University from 3 majors: General Medicine, Preventive Medicine, Nursing (3672 invited students); from 7th to 29th of April 2020; using an online questionnaire that included demographic and academic information, the Vietnamese version of the SF-36 Quality of Life questionnaire and the Fear of COVID-19 Scale (FCV-19S). Linear and modified Poisson regression was used to examine the association between quality of life, changes in quality of life and other factors.

Results
The number of participants was 1583 (response rate 43%). Among 8 dimensions of the SF-36 (ranged 0–100), Vitality had the lowest score with a median score of 46. The median physical composite score (PCS) of the sample was 40.6 (IQR:20.8–53.2), 33.5% of the sample had an above-population average PCS score. The median mental composite score (MCS) of the sample was 20.3 (IQR:3.8–31.7), and 98.2% had an MCS score below average. 9.9% (95%CI:8.5%–11.4%) of the population reported a significant negative change in the quality of life. Fear of COVID-19 was not associated with significant changes in quality of life, nor MCS while having some association with PCS (Coef:-5.39;95%CI:-3to-7.8). Perceived reduction in quality of life was also associated with: being on clinical rotation COVID-19 (PR:1.5;95%CI:1.05–2.2), difficulties affording health services (PR:1.4;95%CI:1.02–1.95), obesity (PR:2.38;95%CI:1.08–5.25) and chronic disease (PR:1.92;95%CI:1.23–3), typical symptoms (PR:1.85; 95%CI:1.23–2.78) and atypical symptoms of COVID-19 (PR:2.32;95%CI:1.41–3.81).

Conclusion
The majority of medical and nursing students had below average quality of life, with lower vitality and mental composite health score in the settings of COVID-19. Perceived decrease in quality of life was associated with clinical rotation, difficulties affording healthcare services and was not associated with Fear of COVID-19.
Integrasi Pendidikan Karakter melalui Pembudayaan Sekolah di SD Muhammadiyah Wirobrajan 3 Yogyakarta
Authors: Nailasariy Asniyah 
Published: December 2022

The objective of the article is to describe the implementation of character education through school culture, which was exemplified at SD Muhammadiyah Wirobrajan 3 Yogyakarta. The implementation of integrated character education in school culture is one of the alternatives to prevent deviant actions taken by the nation's children today. The method used in this research is descriptive analytic with a qualitative approach. The results showed that the character culture process could be integrated into various elements including; vision and mission of the school, professional leadership management, personnel commitment, utilizing teacher competence, cultivating positive attitudes, exemplary school members, adequate infrastructure, cultivating positive interactions, and building a comfortable atmosphere, and by maximizing school management patterns.
Keywords: Integrative Character Education, School Culture
Powiatowe centrum pomocy rodzinie w perspektywie kryzysów pieczy zastępczej. W stronę transformacji działania
Authors: Rutkowski Jarosław 
Published: December 2022

The article indicates that in the presence of various crises of foster care, there is a confusion of the district family support center, institutions not seeing and not hearing the needs of foster families and orphanages. It is emphasized that the reconstruction of the ability to hear problems and see the complex issues of foster care, for the district aid institution to go beyond the horizon of foster care, crises requires the dialogue and the courage to act in the field of social matters. Then, in the conditions of a local community, where the dialogue is practised, the district family support center regains the ability to see and hear the matters of the wounded world. As a result, the district family support center shapes the capacity of communication activities accompanied with the development of the local community. At the same time, this shift towards district local communities inhabitants’ everyday life is expressed in active care for foster care within the framework of dialogue workshops and educational activities. Such an orientation, in a trialectic perspective, in the weave of three dimensions of space the internal micro-space of the institution, the meso-space of foster care and the macro-social space of the local community – allows the district family support center to transform its activities in the field of social affairs, and experience the recognition of the inhabitants of local communities.
The path planning of collision avoidance for an unmanned ship navigating in waterways based on an artificial neural network
Authors: Wang Renqiang , Miao Keyin , Li Qinrong , Sun Jianming , Deng Hua 
Published: December 2022

Abstract
Designing a safe, collision-free navigation route is critical for unmanned ships. This article applies the path planning method to the generation of collision avoidance paths for unmanned ships. Since the path length function is obtained from the distribution points constructed in space, it is necessary to transfer the safe domain of the unmanned ship to the obstacle, treating the unmanned ship as a particle. Then, the constructed artificial neural network (ANN) is applied to compute the collision penalty function for distribution points and obstacles. Furthermore, an evaluation function including the path length function and collision penalty function is designed, and the optimal path is obtained by computing the minimum value of the evaluation function. Meanwhile, the simulated annealing method is introduced to optimize the activation function of the output layer of the ANN to improve its classification performance and suppress the local minima problem. Finally, the application of ANN in ship autonomous dynamic collision avoidance path planning is demonstrated in two types of experiments. Among them, when avoiding static obstacles, the minimum safe passing distance between the two ships reaches 30 m; when avoiding dynamic obstacles (navigating ships), the minimum safe passing distances between the two ships in the head-on situation and the overtaking situation are 378 and 430 m, respectively.
Quantifying Patterns in Mortuary Practices: An Application of Factor Analysis and Cluster Analysis to Data From the Taosi Site, China
Authors: Bai Yang 
Published: December 2022

Abstract
In Chinese mortuary research, too much reliance on traditional qualitative typological analysis renders quantitative attributes of mortuary practice data ignored. Examining the Taosi cemetery one of the famous cemeteries of Neolithic China (2300–1900 BC), this study discusses the advantages and disadvantages of typology and digital methods. Extant qualitative research has classified the Taosi burials into six vertical categories, representing a pyramidal social hierarchy. However, this approach solely relied on the labor expenditure principle, whose outcome was highly subjective and difficult to verify. This study applies a multivariant analysis. Factor analysis is used to investigate the correlations within the mortuary data. The statistical factor scores quantify the differences between the combination of burial objects in different tombs and allow clarification by cluster analysis to investigate their different social meanings. The results reveal two-axial divisions in the Taosi cemetery: vertical stratification based on hierarchy and horizontal differentiation based on social categories/identities. Compared with the simplistic typological description, such a quantitative method reveals the characteristics of each category more clearly, clarifies the classification criteria, and extracts more detailed information about the society and its mortuary practices.
Short-Term and Long-Term Sensitization Differentially Alters the Composition of an Anterograde Transport Complex inAplysia
Authors: Sadhu Abhishek , Badal Kerriann K. , Zhao Yibo , Ali Adia A. , Swarnkar Supriya , Tsaprailis George , Crynen Gogce C. , Puthanveettil Sathyanarayanan V. 
Published: December 2022

AbstractLong-term memory formation requires anterograde transport of proteins from the soma of a neuron to its distal synaptic terminals. This allows new synaptic connections to be grown and existing ones remodeled. However, we do not yet know which proteins are transported to synapses in response to activity and temporal regulation. Here, using quantitative mass spectrometry, we have profiled anterograde protein cargos of a learning-regulated molecular motor protein kinesin [Aplysiakinesin heavy chain 1 (ApKHC1)] following short-term sensitization (STS) and long-term sensitization (LTS) inAplysia californica. Our results reveal enrichment of specific proteins associated with ApKHC1 following both STS and LTS, as well as temporal changes within 1 and 3 h of LTS training. A significant number of proteins enriched in the ApKHC1 complex participate in synaptic function, and, while some are ubiquitously enriched across training conditions, a few are enriched in response to specific training. For instance, factors aiding new synapse formation, such as synaptotagmin-1, dynamin-1, and calmodulin, are differentially enriched in anterograde complexes 1 h after LTS but are depleted 3 h after LTS. Proteins including gelsolin-like protein 2 and sec23A/sec24A, which function in actin filament stabilization and vesicle transport, respectively, are enriched in cargos 3 h after LTS. These results establish that the composition of anterograde transport complexes undergo experience-dependent specific changes and illuminate dynamic changes in the communication between soma and synapse during learning.
Synthesized Socialism: Soviet Modernity and the Politics of Timbre in the Cold War
Authors: Cornish Gabrielle 
Published: December 2022

Abstract
In this article, I show that contrary to enduring Cold War binaries between Western experimentalism and Soviet socialist realism, the Soviet government strategically deployed electronic music to bolster its image as a modern, forward-looking nation during the early Cold War. Drawing on previously unseen archival sources, oral history interviews, and organological methods, I argue that the Soviet government cultivated a specific politics of timbre through the creation of state-sponsored electronic musical instruments and ensembles. I begin by examining a 1955 order from the Ministry of Culture, by which engineers and inventors were tasked with building electronic instruments that sounded “modern.” I then follow the development of the Ekvodin, a multivoice synthesizer with a keyboard for easy performance, which the Ministry of Culture heralded as the future of Soviet music. Using the Ekvodin as a case study reveals both the sonic and the ideological values at play in the design of electronic musical instruments. I also explore two “misfires” in Soviet electronic music: the invention of the Il’ston synthesizer and Alfred Schnittke’s Poem about Space. Finally, I analyze the reception of the Ekvodin and the All-Union Radio and Television’s Ensemble of Electromusical Instruments to highlight the ideological debates over how best to “sound modern” in global networks of musical creation. In doing so, the article invites a broad reconsideration of musical aesthetics and politics in the Cold War.
Brassinosteroid signals cooperate with katanin‐mediated microtubule severing to control stamen filament elongation
Authors: Wang Jie , Wang Guangda , Liu Weiwei , Yang Huanhuan , Wang Chaofeng , Chen Weiyue , Zhang Xiaxia , Tian Juan , Yu Yanjun , Li Jia , Xue Yongbiao , Kong Zhaosheng 
Published: December 2022

AbstractProper stamen filament elongation is essential for pollination and plant reproduction. Plant hormones are extensively involved in every stage of stamen development; however, the cellular mechanisms by which phytohormone signals couple with microtubule dynamics to control filament elongation remain unclear. Here, we screened a series of Arabidopsis thaliana mutants showing different microtubule defects and revealed that only those unable to sever microtubules, lue1 and ktn80.1234, displayed differential floral organ elongation with less elongated stamen filaments. Prompted by short stamen filaments and severe decrease in KTN1 and KTN80s expression in qui‐2 lacking five BZR1‐family transcription factors (BFTFs), we investigated the crosstalk between microtubule severing and brassinosteroid (BR) signaling. The BFTFs transcriptionally activate katanin‐encoding genes, and the microtubule‐severing frequency was severely reduced in qui‐2. Taken together, our findings reveal how BRs can regulate cytoskeletal dynamics to coordinate the proper development of reproductive organs.
Systematic identification and characterization of repressive domains in Drosophila transcription factors
Authors: Klaus Loni , de Almeida Bernardo P , Vlasova Anna , Nemčko Filip , Schleiffer Alexander , Bergauer Katharina , Hofbauer Lorena , Rath Martina , Stark Alexander 
Published: December 2022

AbstractAll multicellular life relies on differential gene expression, determined by regulatory DNA elements and DNA‐binding transcription factors that mediate activation and repression via cofactor recruitment. While activators have been extensively characterized, repressors are less well studied: the identities and properties of their repressive domains (RDs) are typically unknown and the specific co‐repressors (CoRs) they recruit have not been determined. Here, we develop a high‐throughput, next‐generation sequencing‐based screening method, repressive‐domain (RD)‐seq, to systematically identify RDs in complex DNA‐fragment libraries. Screening more than 200,000 fragments covering the coding sequences of all transcription‐related proteins in Drosophila melanogaster, we identify 195 RDs in known repressors and in proteins not previously associated with repression. Many RDs contain recurrent short peptide motifs, which are conserved between fly and human and are required for RD function, as demonstrated by motif mutagenesis. Moreover, we show that RDs that contain one of five distinct repressive motifs interact with and depend on different CoRs, such as Groucho, CtBP, Sin3A, or Smrter. These findings advance our understanding of repressors, their sequences, and the functional impact of sequence‐altering mutations and should provide a valuable resource for further studies.
Rowan Hillson Inpatient Safety Award 2022
Authors: Dashora Umesh , Kempegowda Punith , Li Adrian , Harris Sophie , Castro Erwin , Hillson Rowan , Jones Christine , Dhatariya Ketan 
Published: December 2022

Introduction: The annual National Diabetes Inpatient Audit (NaDIA and NaDIA-Harms) in the UK continues to show signiﬁcant problems with patient care. During the COVID pandemic patient care has been even more difﬁcult. New initiatives are urgently required to improve inpatient safety for people with diabetes.
Method: The Joint British Diabetes Societies for Inpatient Care (JBDS-IP) organised the seventh national Rowan Hillson Inpatient Safety Award on the theme of “the best interventions: redesigning, rebuilding and maintaining safe inpatient diabetes care during COVID”.
Result: The winner was the DEKODE team, led by Dr Punith Kempegowda from University Hospitals Birmingham NHS Foundation Trust, for their innovative quality improvement project across hospitals during COVID to improve diabetes-related ketoacidosis (DKA) management and study DKA in people with COVID. Adherence to national guidance improved in some hospitals, with falls in hypoglycaemia, and overall there was a signiﬁcant improvement in awareness about DKA amongst junior doctors.
The King’s College NHS Foundation Trust team, led by Adrian Li and colleagues, received the highly commended award for their innovative project of remote blood glucose (BG) monitoring across healthcare boundaries. This improved diabetes control and tackled health inequalities.
Summary and conclusion: These and similar schemes need to be developed, promoted and shared to improve safety for people with diabetes admitted in hospital during COVID times.
ФІЗИЧНЕ МОДЕЛЮВАННЯ ПРОЦЕСУ ВИДАЛЕННЯ ВОЛОГИ В МІКРОХВИЛЬОВИХ СТРІЧКОВИХ СУШИЛЬНИХ АПАРАТАХ
Authors: Яровий Ігор Іванович , Алі Віта Петрівна 
Published: December 2022

Стаття відображає завершений етап наукового дослідження. Загальним напрямом наукової роботи є впровадження технологій адресної доставки енергії у процеси сушіння, стерилізації та теплової обробки харчових продуктів і сировини.
В роботі приведено короткий аналіз актуальності наукової тематики за тегом «мікрохвильове сушіння». Описано типову конструкцію сушильних установок стрічкового типу. Для більшості мікрохвильових апаратів відсутня систематизована інформація про доцільні режими обробки вологих матеріалів та типові параметри процесів вологовидалення, що ускладнює можливість їх інтеграції в існуючі технологічні процеси. Одним з факторів прискорення розвитку технологій мікрохвильового сушіння може стати накопичення та систематизація інформації про доцільні режими та обмеження процесів МХ сушіння для типової рослинної сировини.
Експериментальне моделювання процесу видалення вологи в МХ установках розглядається як доцільний шлях дослідження даного типу процесів. Пропонується дослідити типові режими для обробки рослинної сировини з наступною систематизацією отриманих залежностей.
Типові умови взаємодії мікрохвильового електромагнітного поля та рухомого шару вологого матеріалу в таких установках доцільно змоделювати за допомогою спеціального стенду та відповідної методики. Основним завданням стенду є створення умов для точного і зручного моделювання впливу МХ випромінювання сушильної камери на зразок вологого матеріалу з заданими характеристиками шару. Режим обробки матеріалу в багатозонній сушарці моделюється шляхом повторів проходження зразка через сушильну камеру.
Приведено опис конструкції розробленого дослідного стенду. Описано методику проведення експерименту. Описано сировину, що використовувалась для проведення дослідження. Приведено результуючі залежності отримані в ході експериментів. Приведено порівняльну оцінку отриманих результатів з попередніми дослідженнями. Визначено напрям та задачі наступного етапу дослідження.