bluuebunny/crossref_metadata_2025_split huggingface dataset:
A finite volume penalty‐based implicit procedure for the treatment of the frictionless contact boundaries
Authors: Batistić Ivan , Cardiff Philip , Ivanković Alojz , Tuković Željko 
Published: June 2023

AbstractThis article presents a new implicit coupling procedure for mechanical contact simulations using an implicit cell‐centred finite volume method. Both contact boundaries are treated as Neumann conditions, where the prescribed contact force is calculated using a penalty law, which is linearised and updated within the iterative solution procedure. Compared to the currently available explicit treatment, the implicit treatment offers better efficiency for the same accuracy. This is achieved with the proposed implicit linearisation, which replaces the explicit under‐relaxation of the contact force. The proposed procedure, intended for frictionless contact of Hookean solids, can handle non‐conformal contact interface discretisations and faces in partial contact. The accuracy and efficiency of the implicit approach are compared with the explicit procedure on four benchmark problems, where it is shown that the proposed method can significantly improve efficiency and robustness.
Teaching student philanthropy—Possibilities for practice within the UK higher education sector
Authors: Body Alison , Lau Emily 
Published: June 2023

AbstractThis practice paper reflects on lessons learnt from an undergraduate philanthropy module introduced across different programmes within the division for the Study of Law, Society, and Social Justice at the University of Kent, United Kingdom. The module applies service‐learning and experiential learning pedagogy to ensure students critically engage with community and societal issues; recognise themselves as philanthropists; and engage in a responsible decision‐making process with their cohort. As one of the first UK Higher Education student philanthropy modules, lessons learnt provide important general reflections for student philanthropy modules internationally, alongside offering a potential ‘blueprint’ within the UK context. Aligning with others (such as McDougle's study) and drawing on critical reflections from students and partners, suggests that experiential learning pedagogy is most successful when carried out in a diverse and multidisciplinary learning space where students reflect on their own moral position alongside others to build consensus.
Effect of nanoclay‐cellulose adhesive bonding and hybrid glass and flax fiber face sheets on flax fiber honeycomb panels
Authors: Govender Sumeshan , Mohan T. P. , Kanny K. 
Published: June 2023

AbstractThis study investigated the feasibility of using natural fiber material to create honeycomb cores, as traditional cores made of aluminum, Nomex, and petroleum‐based materials are not environmentally friendly. The natural fiber honeycomb cores were formed using a 3D printed molding process and were bonded to flax and glass fiber facings to improve the durability of the structures. The addition of cellulose and nanoclay to the adhesive enhanced the flexural strength of the structures by 7.43% and 10.48%, respectively, while also absorbing 8.67% and 8.91% more impact energy than structures bonded with epoxy alone. However, the compressive strength decreased by 10.79% and 13.6% with the addition of cellulose and nanoclay to the adhesive, respectively. Tensile properties were also studied, and the tensile strength of hybrid facings was found to be 69.45% higher than those using solely flax facings. Additionally, hybrid facings effectively reduced moisture uptake, making them hydrophobic and reducing water uptake by 46.89% compared to solely flax facings. Overall, natural fiber honeycomb composite structures showed comparable performance to Nomex and aluminum honeycomb composites, offering favorable properties while being constructed using environmentally friendly materials. The efficient manufacturing process using additive manufacturing makes these structures readily customizable and scalable, leading to their implementation in numerous applications such as aerospace, automotive, and marine industries.
Identification of genes associated with spontaneous regression of neuroblastoma
Authors: Zhang Yunlong , Du Yifei , Wang Min , Li Changchun , Zhao Zhenzhen , Peng Liang , Zhou Jianwu , Wang Shan 
Published: June 2023

AbstractThe study of target genes for the spontaneous regression phenomenon of neuroblastoma (NB) is still unclear. Common differentially expressed genes (DEGs) were identified by differential expression analysis in both public databases for the stage 4 death group and stage 4S survival group. The DEGs were ranked by constructing protein–protein interaction (PPI) network as well as calculating betweenness centrality (BC) values, and the relationship with NB prognosis was determined by performing univariate analysis, multifactor analysis, and lasso regression analysis on the top 10 genes and possibly correlated with spontaneous regression of NB. We identified a total of 173 DEGs, including 143 upregulated genes and 30 downregulated genes. PPI network showed a rich interaction between DEGs. We ranked the DEGs by calculating BC values and showed the top 10 genes, followed by univariate and multifactorial analyses, which showed that GRIA2, NTRK1, SCN9A, SLC18A2, CNR1, PIK3R1, and DGKB were associated with good prognosis, and CNR1 was the most closely associated with prognosis among them. By lasso regression analysis, we constructed a four‐gene risk score formula. We drew a nomogram to use in clinical work and two newly identified genes associated with good prognosis in NB: CNR1 and GIRA2.
Primary lymphoma of bone in children: Three case reports and literature review
Authors: Zhang Man , Xiao Jianwen , Liu Xing , Zhang Ziyuan , Li Xiang , Shi MingYan , Wang Peikang , Zhang Xinkai , Yao Hailun 
Published: June 2023

AbstractPrimary lymphoma of the bone (PLB) is a rare form of extranodal lymphoma. The clinical features and imaging findings of PLB are not specific. Histological examination and immunophenotyping is the gold standard for diagnosis. We reported three cases, all diagnosed with B‐cell lymphoblastic lymphoma. The first patient is a 4‐year‐old boy with 6 months history of PLB. Lytic permeative areas with soft‐tissue masses showed on imaging. A mutation of the FANCA gene of this patient was detected through whole exome sequencing (WES). The second patient is a 17‐year‐old boy with multiple areas of pain over 2 months. Flurodeoxyglucose positron emission tomography/computed tomography showed that the density of multiple bones was slightly increased. WES revealed a heterozygous splice site variation in the SBDS gene. The third patient is a 3‐year‐old boy with swelling and pain of the left knee joint and fever for 43 days. An oval like lesion area appeared on imaging. The display of case details helps to diagnose and understand PLB. The correlation between the occurrence and progression of the disease and FANCA gene and SBDS gene mutations remains to be studied.
Global research landscape and burden of disease in pediatrics: Identifying the research gaps to set directions for a new general pediatric journal
Authors: Estill Janne , Chen Yaolong 
Published: June 2023

AbstractPediatrics intersects with almost the entire field of medicine, and thus the diversity of suitable publication platforms is particularly broad. We reviewed the current health issues among children and adolescents, the topics and scope of existing pediatric journals, as well as the distribution of a random selection of articles according to different health topics and journal types. Neurological disorders, mental health, and neonatal conditions were major contributors not only to loss of health and life among children and adolescents but also common themes of research articles and pediatric subspecialty journals. On the other hand, in some clinical areas, such as dermatology, the research does not necessarily meet the needs of practice. Methodological studies in pediatrics were rarely published, but they were common among preprints. We call for Pediatric Discovery to promote a research viewpoint that focuses on the child instead of individual conditions, pay particular attention to health concerns associated with the greatest burden and interactions between them, and promote the further standardization of reporting and methodologies that account for the unique characteristics of children and adolescents.
Craniofrontonasal dysplasia: A case report
Authors: Ghosh Kanad , Xu Hope , Roy Mélissa , Yamini Bakhtiar , Reid Russell R. 
Published: June 2023

AbstractCraniofrontonasal dysplasia (CFND) is a rare congenital malformation, which has a wide array of symptoms that can vary drastically between patients. These include coronal synostosis with associated brachycephaly, hypertelorism, cleft lip and palate, and limb malformations, among others. The pleomorphic nature of the disease and numerous clinical decisions required for its management present a unique challenge to craniofacial surgeons when considering indications and timing for surgical intervention. In this report, we present the case of a patient with CFND, their surgical management, and discuss updates in principles of management of CFND.
A green tea extract catechin EGCg: Therapeutic potential for pediatric cardiomyopathies
Authors: Quan Junjun , Gerber Dustin , Li Ang , Huang Xupei , Tian Jie 
Published: June 2023

AbstractCardiomyopathies comprise a group of disorders wherein the primary defect is in cardiac myocytes. The common forms of pediatric cardiomyopathies, classified according to their morphological and functional manifestations, include dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM), hypertrophic cardiomyopathy (HCM), and others. Cardiac gene mutations caused abnormal myofibril Ca2+ sensitivity may be involved in the underlying molecular mechanisms of cardiomyopathies. Thus far, no effective treatment for cardiomyopathies has been developed, especially for HCM and RCM in which diastolic dysfunction occurs early and followed by diastolic heart failure. Our laboratory is among the first in the field to investigate the mechanisms underlying various cardiomyopathies and search for the treatment for these disorders. In the past, we and other researchers have found that (−)‐epigallocatechin‐3‐gallate (EGCg), the major biomedical polyphenol extracted from green tea, possess multiple therapeutic effects on protecting cardiac function and correcting impaired relaxation. Given its therapeutic effects, EGCg might be a potential drug candidate for administration to patients with cardiomyopathy and heart failure. In this review, we will discuss the molecular mechanisms associated with the pathogenesis of diastolic dysfunction and summarize the pharmacological effects of EGCg on experimental animals and pediatric patients with cardiomyopathies and diastolic dysfunction.
Biomarkers in the intensive care setting: A focus on using procalcitonin and C‐reactive protein to optimize antimicrobial duration of therapy
Authors: August Benjamin A. , Kale‐Pradhan Pramodini B. , Giuliano Christopher , Johnson Leonard B. 
Published: June 2023

AbstractManaging the critically ill patient with infection is complex, requiring clinicians to synthesize considerable information relating to antimicrobial efficacy and treatment duration. The use of biomarkers may play an important role in identifying variation in treatment response and providing information about treatment efficacy. Though a vast number of biomarkers for clinical application have been described, procalcitonin and C‐reactive protein (CRP) are the most thoroughly investigated in the critically ill. However, the presence of heterogeneous populations, variable end points, and incongruent methodology in the literature complicates the use of such biomarkers to guide antimicrobial therapy. This review focuses on an appraisal of evidence for use of procalcitonin and CRP to optimize antimicrobial duration of therapy (DOT) in critically ill patients. Procalcitonin‐guided antimicrobial therapy in mixed critically ill populations with varying degrees of sepsis appears to be safe and might assist in reducing antimicrobial DOT. Compared to procalcitonin, fewer studies exist examining the impact of CRP on antimicrobial DOT and clinical outcomes in the critically ill. Procalcitonin and CRP have been insufficiently studied in many key intensive care unit populations, including surgical patients with concomitant trauma, renally insufficient populations, the immunocompromised, and patients with septic shock. We believe the available evidence is not strong enough to warrant routine use of procalcitonin or CRP to guide antimicrobial DOT in critically ill patients with infection. So long as its limitations are recognized, procalcitonin could be considered to tailor antimicrobial DOT on a case‐by‐case basis in the critically ill patient.
The effect of toluene trace admixtures on the plasma‐assisted oxygen trace removal from hydrogen‐rich gas mixtures in a surface dielectric barrier discharge reactor
Authors: Oberste‐Beulmann Christian , Oppotsch Timothy , Muhler Martin 
Published: June 2023

AbstractA surface dielectric barrier discharge reactor was applied in the removal of oxygen traces from coke oven gas (COG), to which toluene was added as a model hydrocarbon contaminant. The adverse effect of toluene on O2 conversion was observed in a H2/N2/O2 mixture, while in synthetic COG consisting of H2, CH4, N2, CO, CO2, and O2, it remained unchanged. Online gas chromatography (GC) showed that the reactivity of toluene is mainly driven by H2/N2/O2. The accumulated residue was dissolved and analyzed by GC coupled with mass spectrometry. The identified reaction products suggest that toluene undergoes ring‐opening and functionalization.
Charged Accelerating BTZ Black Holes
Authors: Eslam Panah B. 
Published: June 2023

AbstractIn this paper, general uncharged accelerating BTZ black hole solutions are extracted and studied some of their properties. The analysis shows that spacetime's asymptotic behavior depends on four parameters: the cosmological constant, mass, acceleration, and topological constant. Then, the temperature of these black holes are studied and it is found that the temperature is always positive for AdS spacetime. Next, the study is extended for extracting charged accelerating BTZ black hole solutions in the presence of a nonlinear electrodynamics field known as conformally invariant Maxwell. The findings indicate a coupling between the electrical charge and other quantities of the accelerating BTZ black holes. The asymptotic behavior of charged accelerating BTZ black holes depends on five parameters: the cosmological constant, the electrical charge, mass, the acceleration parameter, and the topological constant. Then, the effects of charge, acceleration parameters, and the topological constant on the root of these black holes are studied. Finally, the temperature of these black holes in AdS spacetime is investigated. For these black holes, the temperature depends on the electrical charge, accelerating parameter, and the cosmological constant. The analysis indicates that the temperature of charged accelerating BTZ AdS black holes is always positive.
Comparative efficacy trials with alcohol added d‐phenothrin formulations against Aedes aegypti under open‐field condition
Authors: Megat Nabil Mohsin Sumaiyah , Ahmad Norashikin , Yusof Yusrabbil Amiyati 
Published: June 2023

AbstractBACKGROUNDEvaporation inhibition of water‐based space spray insecticides is necessary to prevent the drifting away of fog droplets and the release of insecticidal actives and to prolong suspension time. To address this problem, hygroscopic alcohols, namely propylene glycol and glycerol, were included as adjuvants in water‐based d‐phenothrin formulations. The performances of glycerol‐added formulation (D1) and propylene glycol‐added formulation (D2) in terms of droplet size and efficacy against larvae, pupae and adult Aedes aegypti in an open‐field environment were examined and compared to the performance of a formulation without adjuvant (negative control).RESULTSNo significant difference in droplet size was observed between the formulations and fogging methods. The efficacy of cold fogs was significantly higher than thermal fogs for all formulations. D2 was found to be most effective against adult Ae. aegypti, followed by D1 and the negative control. D1 and D2 provided complete knockdown and mortality in adult Ae. aegypti at 10 and 25 m for cold and thermal fogging, respectively. However, all d‐phenothrin formulations possessed minimal efficacy on immature Ae. aegypti.CONCLUSIONThe incorporation of non‐toxic alcohols as adjuvants in water‐based space spray insecticides increased efficacy against adult Ae. aegypti, a major vector for dengue. Propylene glycol was discovered to induce higher adulticidal efficacy than glycerol. © 2023 Society of Chemical Industry.
11‐Ethoxyviburtinal improves chronic restraint stress‐induced anxiety‐like behaviors in gender‐specific mice via PI3K/Akt and E2/ERβ signaling pathways
Authors: Lyu Yan , Wei Xiaojia , Yang Xue , Li Jiayuan , Wan Guohui , Wang Yuqing , Hao Zhuangzhuang , Lu Yifan , Guo Jianyou , Shi Jinli 
Published: June 2023

AbstractAnxiety disorder is a chronic and disabling psychiatric disorder that is more prevalent in females than in males. 11‐Ethoxyviburtinal is an iridoid extracted from Valeriana jatamansi Jones, which has anxiolytic potential. The aim of the present work was to study the anxiolytic efficacy and mechanism of 11‐ethoxyviburtinal in gender‐specific mice. We first evaluated the anxiolytic‐like efficacy of 11‐ethoxyviburtinal in chronic restraint stress (CRS) mice of different sexes through behavioral experiments and biochemical indexes. In addition, network pharmacology and molecular docking were used to predict potential targets and important pathways for the treatment of anxiety disorder with 11‐ethoxyviburtinal. Finally, the influence of 11‐ethoxyviburtinal on phosphoinositide‐3‐kinase (PI3K)/protein kinase B (Akt) signaling pathway, estrogen receptor β (ERβ) expression, and anxiety‐like behavior in mice was verified by western blotting, immunohistochemistry staining, antagonist intervention methods, and behavioral experiments. 11‐ethoxyviburtinal alleviated the anxiety‐like behaviors induced by CRS and inhibited neurotransmitter dysregulation and HPA axis hyperactivity. It inhibited the abnormal activation of the PI3K/Akt signaling pathway, modulated estrogen production, and promoted ERβ expression in mice. In addition, the female mice may be more sensitive to the pharmacological effects of 11‐ethoxyviburtinal. 11‐ethoxyviburtinal may exert its anxiolytic‐like effects through PI3K/Akt and E2/ERβ signaling pathways. Meanwhile, by comparing the male and female mice, gender differences may affect the therapy and development of anxiety disorder.
Pulmonary hypertension secondary to interstitial fibrosis with pulmonary venous lesions masquerading pulmonary veno‐occlusive disease
Authors: Nakayama Hiroki , Ishida Masayuki , Nakaoka Hiroshi , Nishimura Yuki , Imai Ryu‐ichirou , Sugane Hiroki , Hosoda Hayato , Nakaoka Yoko , Nishida Koji , Seki Shu‐ichi , Kubokawa Sho‐ichi , Kawai Kazuya , Hamashige Naohisa , Doi Yoshinori 
Published: June 2023

AbstractWe present a 41‐year‐old man with idiopathic interstitial pneumonia and pulmonary hypertension (PH) in the setting of a non‐autoimmune background whose clinical presentation masqueraded pulmonary veno‐occlusive disease (PVOD). Because of no histological evidence of venous occlusion in his previous lung biopsy, phosphodiesterase type‐5 inhibitor was given, resulting in sudden onset of pulmonary edema. At autopsy, there were histological features of interstitial fibrosis with occlusion of the lobular septal veins and venules. Clinical presentations of PH due to interstitial fibrosis with pulmonary venous lesions may simulate those of PVOD and careful diagnostic and therapeutic approaches are required.
A new finite time control method to nonlinear systems with uncertain dynamics and time‐varying powers
Authors: Xue Lingrong , Liu Zhen‐Guo , Zhang Weihai 
Published: June 2023

AbstractThe existing researches mainly focused on control issues of systems with constant powers. In practical engineering, it shows that some dynamic systems have time‐varying powers, which result in the inapplicability of many reported methods. Besides, nonlinear systems constantly suffer from uncertain dynamics. This article discusses the control issue of systems which possess uncertain dynamics and time‐varying powers. By introducing a new Lyapunov function which contains quadratic components and high‐order components and raising a novel recursive design strategy, we successfully design a semi‐global practical finite time controller which allows uncertain dynamics and larger range of system powers. Numerical and practical examples show that the presented strategy is valid.
Neural‐network‐based event‐triggered adaptive security path following control of autonomous ground vehicles subject to abnormal actuator signal
Authors: Sun Hong‐Tao , Zhang Pengfei , Peng Chen , Zhang Yajian 
Published: June 2023

AbstractThe malicious physical attacks from both sensor and actuator sides make real threats to the security and safety of autonomous ground vehicles (AGVs). This paper focuses on the problem of neural‐network‐based event‐triggered adaptive security control (ET‐ASC) scheme for path following of AGVs subject to arbitrary abnormal actuator signal. First, we assume that an arbitrary abnormal signal is caused by arbitrary malicious attacks or disturbances from actuators. Then, radial basis function neural network (RBF‐NN) is used to reconstruct such abnormal actuator signal. Second, modelling issues on security path following control of AGVs with Sigmoid‐like ETC scheme are shown when the AGV is suffering from abnormal actuator signal. In what follows, an ET‐ASC scheme is developed to mitigate the adverse effects of abnormal actuator signal with the reconstructed abnormal signal based on a novel Sigmoid‐like event‐triggered communication scheme. By using the proposed RBF‐NN‐based ET‐ASC scheme, control performance can be guaranteed under arbitrary malicious actuator signal rather than such attacks following a specific probability distribution. Final, some simulation experiments are provided to verify the effectiveness of proposed ET‐ASC scheme.
MOF‐Derived Mn2O3 Nanocage with Oxygen Vacancies as Efficient Cathode Catalysts for Li–O2 Batteries
Authors: Zhao Lingwen , Feng Juanjuan , Abbas Adeel , Wang Chunlei , Wang Hongchao 
Published: June 2023

AbstractDesigning efficient and cost‐effective electrocatalysts is the primary imperative for addressing the pivotal concerns confronting lithium–oxygen batteries (LOBs). The microstructure of the catalyst is one of the key factors that influence the catalytic performance. This study proceeds to the advantage of metal‐organic frameworks (MOFs) derivatives by annealing manganese 1,2,3‐triazolate (MET‐2) at different temperatures to optimize Mn2O3 crystals for special microstructures. It is found that at 350 °C annealing temperature, the derived Mn2O3 nanocage maintains the structure of MOF, the inherited high porosity and large specific surface area provide more channels for Li+ and O2 diffusion, beside the oxygen vacancies on the surface of Mn2O3 nanocages enhance the electrocatalytic activity. With the synergy of unique structure and rich oxygen vacancies, the Mn2O3 nanocage exhibits ultrahigh discharge capacity (21 070.6 mAh g−1 at 500 mA g−1) and excellent cycling stability (180 cycles at the limited capacity of 600 mAh g−1 with a current of 500 mA g−1). This study demonstrates that the Mn2O3 nanocage structure containing oxygen vacancies can significantly enhance catalytic performance for LOBs, which provide a simple method for structurally designed transition metal oxide electrocatalysts.