bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction of chiral solitons in a Bose-Einstein Condensate under density-dependent gauge potential
Authors: Gao Rui , Qiao Xin , Ma Yun-E , Jian Yue , Zhang Ai-Xia , Xue Ju-Kui 
Published: February 2023

Abstract
The collision between two chiral solitons in a Bose-Einstein Condensate (BEC) under density-dependent gauge potential is studied. By means of Poincaré-Lighthill-Kuo (PLK) perturbation method, the different kinds of colliding chiral soliton pairs self-consistently excited upon the background of the system are obtained analytically. The coupling of the current nonlinearity induced by the gauge potential and mean-field atomic interaction results in rich collision dynamics of chiral soliton pairs. When the atomic interaction is repulsive, head-on collisions of dark-dark and dark-bright solitons are observed. However, when the atomic interaction is attractive, unidirectional chiral dark soliton pairs are excited, and overtaking collision between two chiral dark solitons takes place. The phase shifts following the collision of soliton pairs are derived analytically and confirmed numerically. Interestingly, due to the contribution of the density-dependent gauge potential, the phase shifts of the two interacting chiral solitons are different from each other. This is distinct from the case without the density-dependent gauge potential, where the phase shifts of the two colliding ordinary solitons are the same. Thus, phase shifts of interacting chiral soliton pairs can be used to identify the chiral properties of solitons in BEC under density-dependent gauge potential. Furthermore, both elastic and inelastic collisions of chiral solitons in the system are presented numerically. The phase diagram for occurrence of elastic and inelastic collisions of chiral soliton is obtained, which strongly depends on the strength of density-dependent gauge potential.
The Influence of Early-Life Health Conditions on Life Course Health
Authors: Flores Manuel , Wolfe Barbara L. 
Published: February 2023

AbstractWe expand on previous studies investigating the links between early health and later health by examining four distinct dimensions of early-life health and multiple life course outcomes, including the age of onset of serious cardiovascular diseases (CVDs) and several job-related health outcomes. The four dimensions of childhood health are mental, physical, self-reported general health, and severe headaches or migraines. The data set we use includes men and women in 21 countries from the Survey of Health, Ageing and Retirement in Europe. We find that the different dimensions of childhood health have unique ties to later outcomes. For men, early mental health problems play a stronger role for life course job-related health outcomes, but early poor/fair general health is more strongly linked to the spike in onset of CVDs in their late 40s. For women, these links between childhood health dimensions and life course outcomes are similar but are less clear-cut than for men. The spike in onset of CVDs in women's late 40s is driven by those with severe headaches or migraines, while those with early poor/fair general health or mental health problems do worse as captured by job-related outcomes. We also delve into and control for possible mediating factors. Exploring the links between several dimensions of childhood health and multiple health-related life course outcomes will enable a better understanding of how health inequalities originate and are shaped over the course of people's lives.
Later, Fewer, None? Recent Trends in Cohort Fertility in South Korea
Authors: Hwang Jisoo 
Published: February 2023

AbstractSouth Korea and other developed regions in East Asia have become forerunners of prolonged lowest-low fertility. South Korea's total fertility rate has been below 1.3 for two decades, the longest duration among OECD countries. Using vital statistics and census data, I study recent trends in the country's cohort fertility covering women born before the 1960s to those born in the 1980s. Analyzing outcomes at both the intensive margin of fertility (i.e., timing and number of children) and the extensive margin of family formation (i.e., marriage and childlessness), I document three novel patterns. First, the driver of low fertility has evolved across birth cohorts, from married women having later and fewer childbirths, to fewer women getting married, and finally to fewer women having children even if married. Second, a decomposition analysis of marriage and fertility changes indicates that the marriage and fertility decline was driven by changes within educational groups rather than by changes in women's educational composition. Third, the relationship between women's educational attainment and marriage or fertility was negative for the 1960s cohort, but an inverted U-shaped education gradient emerged beginning with the 1970s cohort.
Disappearing Rooms
Authors: Castañeda Michelle 
Published: February 2023

In Disappearing Rooms Michelle Castañeda lays bare the criminalization of race enacted every day in US immigration courts and detention centers. She uses a performance studies perspective to show how the theatrical concept of mise-en-scène offers new insights about immigration law and the absurdist dynamics of carceral space. Castañeda draws upon her experiences in immigration trials as an interpreter and courtroom companion to analyze the scenography—lighting, staging, framing, gesture, speech, and choreography—of specific rooms within the immigration enforcement system. Castañeda’s ethnographies of proceedings in a “removal” office in New York City, a detention center courtroom in Texas, and an asylum office in the Northeast reveal the depersonalizing violence enacted in immigration law through its embodied, ritualistic, and affective components. She shows how the creative practices of detained and disappeared people living under acute duress imagine the abolition of detention and borders. Featuring original illustrations by artist-journalist Molly Crabapple, Disappearing Rooms shines a light into otherwise hidden spaces of law within the contemporary deportation regime.
Duke University of Press Scholars of Color First Book Award Recipient
Antimicrobial peptides do not directly contribute to aging in Drosophila, but improve lifespan by preventing dysbiosis
Authors: Hanson Mark A. , Lemaitre Bruno 
Published: February 2023

ABSTRACT
Antimicrobial peptides (AMPs) are innate immune effectors first studied for their role in host defence. Recent studies have implicated these peptides in the clearance of aberrant cells and in neurodegenerative syndromes. In Drosophila, many AMPs are produced downstream of Toll and Imd NF-κB pathways upon infection. Upon aging, AMPs are upregulated, drawing attention to these molecules as possible causes of age-associated inflammatory diseases. However, functional studies overexpressing or silencing these genes have been inconclusive. Using an isogenic set of AMP gene deletions, we investigated the net impact of AMPs on aging. Overall, we found no major effect of individual AMPs on lifespan, with the possible exception of Defensin. However, ΔAMP14 flies lacking seven AMP gene families displayed reduced lifespan. Increased bacterial load in the food of aged ΔAMP14 flies suggested that their lifespan reduction was due to microbiome dysbiosis, consistent with a previous study. Moreover, germ-free conditions extended the lifespan of ΔAMP14 flies. Overall, our results did not point to an overt role of individual AMPs in lifespan. Instead, we found that AMPs collectively impact lifespan by preventing dysbiosis during aging.
Termination of the Chirality Confusion of Peribysins
Authors: Kanehara Ryuhi , Tanaka Kazuaki , Yamada Takeshi , Koshino Hiroyuki , Hashimoto Masaru 
Published: February 2023

Abstract
Peribysins belong to a family of eremophilanes isolated from marine Periconia byssoides OUPS-N133 and terrestrial P. macrospinosa KT3863. Their absolute configurations were determined to be the (4S)-enantiomers based on the modified Mosher’s method, chemical derivatizations, density functional theory (DFT)-based electronic circular dichroism (ECD) spectral analysis, and DFT-based [α]D calculations. Danishefsky’s and Reddy’s total syntheses assigned the (4R)-forms for the marine peribysins despite agreeing with the (4S)-configuration for the terrestrial peribysin Q (5). This paper reports the successful solution of this chirality confusion of peribysins by reproducing the ECD spectrum of peribysin G bis(p-bromobenzoate) prepared from peribysin A (1) isolated from terrestrial P. byssoides TS60. 2β-Hydroxyperibysin A (6), which was isolated by changing the culture conditions of the above fungus, was converted to (4S)-peribysin E MTPA esters. These compounds showed identical 1H NMR spectral properties to those reported in the isolation paper.
Therapeutically applied Minecraft groups with neurodivergent youth
Authors: Kilmer Elizabeth , Spangler Johnny , Kilmer Jared 
Published: February 2023

Background: Therapeutically applied Minecraft groups are an intervention designed to support social engagement and growth in youth. The flexible interaction format and use of a popular digital game support the fit of this intervention for use with neurodivergent youth. Minecraft is leveraged to support opportunities to build authentic relationships and social confidence in an engaging, low-stakes environment with peers. The group format allows for real-world social practice with peers, while the game environment can create motivation to interact with others, and provides multiple modes for such interaction (i.e., chat, building/movement with the avatar). Methods: This article outlines the theoretical foundations of therapeutically applied Minecraft groups as well as practical considerations for implementation. The method outlined includes the justification for this method, process of creating support groups, check-in and check-out processes, and in-game activity examples for different situations. Results: Use cases are included to illustrate how the methods have been used in the past to support social growth with neurodivergent youth. Use cases include examples of different Minecraft servers, such as the habitat, and identifying stresses of social growth such as school anxiety and how the use of therapeutically applied Minecraft helped. Conclusions: Therapeutically applied Minecraft can provide opportunities for peer connection and social practice in a facilitated environment. Though the use of Minecraft and other games to support learning and social connection is prevalent in the media, the academic research in this area is sparse. This article provides general guidelines for therapeutically applied Minecraft groups as well as calls for more formal research in this area.
The impact of COVID-19 severity on pregnancy outcomes among Iraqi women: a retrospective observational study
Authors: Sami Salih Othman , Khalid Abdulridha Manal 
Published: February 2023

Background: COVID-19-infected pregnant women may be asymptomatic or symptomatic. Symptomatic tend to have a severe infection and could be at increased risk of complications such as preterm birth, NICU, and stillbirth. This study aimed to identify the most common signs and symptoms and assess the pre-existing risk of COVID-19 infection during pregnancy: length of hospital stay, premature labor, and complications according to the severity of COVID-19 illness. Methods: This retrospective study was conducted in the obstetric and gynecological wards of 359 pregnant women. After reviewing medical records, patient and disease data were collected. Results: Most patients were asymptomatic and mild. The most common signs and symptoms were fever, cough, and dyspnea. COVID-19 infected pregnant with a medical history of hypertension, or diabetes had more severe COVID-19 infection. COVID-19-infected pregnant women with severe illness or aged ≥ 40 years had a prolonged hospital stay. Severe COVID-19 disease was significantly associated with preterm birth, stillbirth, and the need for a neonatal intensive care unit. Conclusion: Severe COVID-19 infection in pregnancy is linked to pregnancy and birth complications, mainly among pregnant women with a positive medical history.
Temporal distribution and clinical characteristics of the Alpha, Delta and Omicron SARS-CoV-2 variants of concern in Laikipia, Kenya: institutional and community-based genomic surveillance
Authors: W. Lambisia Arnold , H. Mudhune Godfrey , M. Morobe John , Said Mohammed Khadija , O. Makori Timothy , Ndwiga Leonard , W. Mburu Maureen , O. Moraa Edidah , Musyoki Jeniffer , Murunga Nickson , N. Waliaula Isaac , K. Mumelo Arthur , Bejon Philip , Isabella Ochola-Oyier Lynette , Githinji George , Nokes James , Agoti Charles 
Published: February 2023

Background: Understanding the molecular epidemiology and clinical presentation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) in rural-urban populations in Kenya is important for informing future public health responses and clinical care. Methods: We undertook a retrospective analysis of the clinical presentation and phylogenetic relatedness of specimens from 97 SARS-CoV-2 cases collected between 24th April and 31st December 2021 in Laikipia county, Kenya. VOC were related to observed symptoms. Phylogenetic analyses included contemporaneous sequences from across Kenya and the globe, to contextualise local transmission dynamics. Results: These sequences fell into three VOC; Alpha (n=8), Delta (n=52) and Omicron (n=37). We estimated 75 independent SARS-CoV-2 introductions into the county. The Alpha and Delta VOC were commonly detected in persons aged 31 to 45 years, 50.0% and 30.8%, respectively. The Omicron VOC was mostly detected in 16 to 30-year-olds (51.4%). Whereas relative to the other VOCs, Omicron was associated with mild upper-respiratory tract symptoms (cough, OR 3.78; 95% CI 1.1 – 16.74, p= 0.026) and sore throat, OR 22.42; 95% CI 7.11 – 81.40, p<0.001), Delta was associated with moderate to severe lower-respiratory tract symptoms (shortness of breath, OR 26.8; 95% CI 3.89 – 1158.14, p<0.001) and fever (OR 6.11; 95% CI 1.57 – 35.35, p= 0.004). Post-acute phase neurological complications were suspected in four Delta infected cases (neuralgia, neuritis, peripheral neuropathy, numbness of hand and tinnitus). Conclusion: We highlight the distinctive clinical characteristics of SARS-CoV-2 VOCs, as observed in Laikipia, Kenya, to support evidence-based clinical decisions. Multiple introductions of the VOCs were recorded despite the public health measures that were in place questioning their effectiveness during the study period.
The New Stakeholder Theory on Organizational Purpose
Authors: McGahan Anita M. 
Published: February 2023

The new stakeholder theory (NST) grapples with two canonical questions: Which stakeholders are enfranchised in organizations? How is the value created through stakeholder collaboration distributed and experienced by stakeholders? This paper first describes how the NST builds on original stakeholder theory to ask these two specific questions. The defining features of the NST are (i) a broad range of dependent variables, (ii) descriptiveness, (iii) formalized analysis, (iv) boundaries on stakeholder enfranchisement, and (v) analytic links to other established theories. The paper then assesses the assumptions and implications of this theory for understanding organizational purpose. A primary idea is that the NST conceptualizes purpose as originating in the goals, needs, and interests of stakeholders as complex, nuanced actors. Under the NST, the organization is conceived of as a tool—a functionalized construction—through which enfranchised stakeholders pursue a shared purpose that leads to experiences of stakeholder value in terms that are defined by the relevant stakeholders themselves. The survival and profitability of an organization depends on its effectiveness and efficiency as a tool for accomplishing mutual stakeholder aims, which are what define organizational purpose.History: This paper has been accepted for the Strategy Science Special Issue on Corporate Purpose.Funding: Funded by Social Sciences and Research Council of Canada.
Referral to the NHS Diabetes Prevention Programme and conversion from nondiabetic hyperglycaemia to type 2 diabetes mellitus in England: A matched cohort analysis
Authors: Ravindrarajah Rathi , Sutton Matt , Reeves David , Cotterill Sarah , Mcmanus Emma , Meacock Rachel , Whittaker William , Soiland-Reyes Claudia , Heller Simon , Bower Peter , Kontopantelis Evangelos 
Published: February 2023

Background
The NHS Diabetes Prevention Programme (NDPP) is a behaviour change programme for adults who are at risk of developing type 2 diabetes mellitus (T2DM): people with raised blood glucose levels, but not in the diabetic range, diagnosed with nondiabetic hyperglycaemia (NDH). We examined the association between referral to the programme and reducing conversion of NDH to T2DM.

Methods and findings
Cohort study of patients attending primary care in England using clinical Practice Research Datalink data from 1 April 2016 (NDPP introduction) to 31 March 2020 was used. To minimise confounding, we matched patients referred to the programme in referring practices to patients in nonreferring practices. Patients were matched based on age (≥3 years), sex, and ≥365 days of NDH diagnosis. Random-effects parametric survival models evaluated the intervention, controlling for numerous covariates. Our primary analysis was selected a priori: complete case analysis, 1-to-1 practice matching, up to 5 controls sampled with replacement. Various sensitivity analyses were conducted, including multiple imputation approaches. Analysis was adjusted for age (at index date), sex, time from NDH diagnosis to index date, BMI, HbA1c, total serum cholesterol, systolic blood pressure, diastolic blood pressure, prescription of metformin, smoking status, socioeconomic status, a diagnosis of depression, and comorbidities.
A total of 18,470 patients referred to NDPP were matched to 51,331 patients not referred to NDPP in the main analysis. Mean follow-up from referral was 482.0 (SD = 317.3) and 472.4 (SD = 309.1) days, for referred to NDPP and not referred to NDPP, respectively. Baseline characteristics in the 2 groups were similar, except referred to NDPP were more likely to have higher BMI and be ever-smokers. The adjusted HR for referred to NDPP, compared to not referred to NDPP, was 0.80 (95% CI: 0.73 to 0.87) (p < 0.001). The probability of not converting to T2DM at 36 months since referral was 87.3% (95% CI: 86.5% to 88.2%) for referred to NDPP and 84.6% (95% CI: 83.9% to 85.4%) for not referred to NDPP. Associations were broadly consistent in the sensitivity analyses, but often smaller in magnitude. As this is an observational study, we cannot conclusively address causality. Other limitations include the inclusion of controls from the other 3 UK countries, data not allowing the evaluation of the association between attendance (rather than referral) and conversion.

Conclusions
The NDPP was associated with reduced conversion rates from NDH to T2DM. Although we observed smaller associations with risk reduction, compared to what has been observed in RCTs, this is unsurprising since we examined the impact of referral, rather than attendance or completion of the intervention.
MiR-942-5p inhibits tumor migration and invasion through targeting CST1 in esophageal squamous cell carcinoma
Authors: Zhang Liangming , Yu Sunxing , Yin Xiaoqing , Tu Mingshu , Cai Liqing , Zhang Yi , Yu Lili , Zhang Songgao , Pan Xiaojie , Huang Yi 
Published: February 2023

IntroductionCysteine Protease Inhibitor 1 (CST1), a cystatin superfamily protein with the effect on the inhibition of cysteine protease activity, is reported to be involved in the development of many malignancies. MiR-942-5p has been demonstrated its regulatory effects on some malignancies. However, the roles of CST1 and miR-942-5p on esophageal squamous cell carcinoma (ESCC) are still unknown up to now.MethodsThe expression of CST1 in ESCC tissues was analyzed by TCGA database, immunohistochemistry, and RT-qPCR, respectively. Matrigel-uncoated or-coated transwell assay was used to determine the effect of CST1 on migration and invasion of ESCC cells. Regulatory effect of miR-942-5p on CST1 was detected by dual luciferase assay.ResultsCST1 was ectopically highly expressed in ESCC tissues, and had the effect on promoting the migration and invasion of ESCC cells by upregulating phosphorylated levels of key effectors including MEK1/2, ERK1/2, and CREB in MEK/ERK/CREB pathway. Dual-luciferase assay results showed that miR-942-5p had a regulatory effect on targeting CST1.ConclusionsCST1 plays a carcinogenic role on ESCC, and miR-942-5p can regulate the migration and invasion of ESCC cells by targeting CST1 to downregulate MEK/ERK/CREB signaling pathway, suggesting that miR-942-5p/CST1 axis might be a promising target for diagnosis and treatment of ESCC.
Patients’ preferences in dental care: A discrete-choice experiment and an analysis of willingness-to-pay
Authors: Felgner Susanne , Henschke Cornelia 
Published: February 2023

Introduction
Dental diseases are a major problem worldwide. Costs are a burden on healthcare systems and patients. Missed treatments can have health and financial consequences. Compared to other health services, dental treatments are only covered in parts by statutory health insurance (SHI). Using the example of dental crowns for a cost-intensive treatment, our study aims to investigate whether (1) certain treatment attributes determine patients’ treatment choice, and (2) out-of-pocket payments represent a barrier to access dental care.

Methods
We conducted a discrete-choice-experiment by mailing questionnaires to 10,752 people in Germany. In presented scenarios the participants could choose between treatment options (A, B, or none) composed of treatment attribute levels (e.g., color of teeth) for posterior (PT) and anterior teeth (AT). Considering interaction effects, we used a D-efficient fractional factorial design. Choice analysis was performed using different models. Furthermore, we analyzed willingness-to-pay (WTP), preference of choosing no and SHI standard care treatment, and influence of socioeconomic characteristics on individual WTP.

Results
Out of n = 762 returned questionnaires (response rate of r = 7.1), n = 380 were included in the analysis. Most of the participants are in age group "50 to 59 years" (n = 103, 27.1%) and female (n = 249, 65.5%). The participants’ benefit allocations varied across treatment attributes. Aesthetics and durability of dental crowns play most important roles in decision-making. WTP regarding natural color teeth is higher than standard SHI out-of-pocket payment. Estimations for AT dominate. For both tooth areas, "no treatment" was a frequent choice (PT: 25.7%, AT: 37.2%). Especially for AT, treatment beyond SHI standard care was often chosen (49.8%, PT: 31.3%). Age, gender, and incentive measures (bonus booklet) influenced WTP per participant.

Conclusion
This study provides important insights into patient preferences for dental crown treatment in Germany. For our participants, aesthetic for AT and PT as well as out-of-pocket payments for PT play an important role in decision-making. Overall, they are willing to pay more than the current out-of-pockt payments for what they consider to be better crown treatments. Findings may be valuable for policy makers in developing measures that better match patient preferences.