bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipodistrofia generalizada congênita: uma revisão bibliográfica
Authors: Bispo Mônica Bento , Freitas Ana Carolina Carli de 
Published: February 2023

Introdução: A Lipodistrofia generalizada congênita é uma patologia que apresenta imensa gama de manifestações clínicas, com inúmeros fatores de risco e importante índice de complicações. Objetivo: O objetivo do trabalho consiste em revisar bibliograficamente a Lipodistrofia congênita, apresentando o quadro clínico, diagnóstico e tratamento preconizado, levando em consideração a baixa incidência de casos relatados e a gravidade da patologia. Método: Uma revisão narrativa de literatura foi realizada utilizando as bases de dados: PubMed, Scielo e UpToDate. Os descritores utilizados foram: “Lipodistrofia”; “Lipodistrofia Generalizada Congênita”, “Resistência insulínica” e “Síndrome Metabólica”. Foram selecionados artigos completos, encontrados nos idiomas: português, inglês ou espanhol. 298 artigos foram pré-selecionados e após verificar-se os critérios de inclusão e exclusão, restaram 33 estudos que foram utilizados para compor o trabalho. Resultados e discussão: A fisiopatologia esta associada a mutações em genes que codificam para diferentes proteínas, que estão envolvidas nas várias etapas da formação de gotículas lipídicas em adipócitos. O quadro clínico mais relatado é relacionado a hepatomegalia e hipertrofia muscular, porém as características podem ser variáveis por tratar-se de uma alteração genética importante. Nota-se frequente associação a intolerância a glicose, hiperinsulinismo, diabetes mellitus, hipertrigliceridemia, esteatose hepática, musculatura proeminente, cardiomiopatia hipertrófica e cistos. O diagnóstico é normalmente clínico, mas necessita da confirmação através do teste genético. O tratamento está relacionado com a gravidade e as complicações apresentadas pelo individuo. Conclusão: estudos quanto ao assunto são necessários para garantia de diagnóstico precoce e acompanhamento dos indivíduos desde a fase pediátrica.
Evolution of complex giant seafloor depressions at the northern Argentine continental margin (SW Atlantic Ocean) under the influence of a dynamic bottom current regime
Authors: Warnke Fynn , Schwenk Tilmann , Miramontes Elda , Spiess Volkhard , Wenau Stefan , Bozzano Graziella , Baqués Michele , Kasten Sabine 
Published: February 2023

Seafloor depressions (SD) are features commonly observed on the ocean floor. They often occur as circular, small-sized (up to 10 s of m) incisions caused by fluid expulsion. Larger depressions (100s m to km) are considerably less abundant, and their origin and development have been scarcely studied. This study investigated two giant morphological depressions (&gt;5 km) using recently acquired multibeam bathymetry and backscatter, sediment echosounder, and high-resolution seismic data. An arc-shaped (SD-N) and a sub-circular depression (SD-S) are located on the Ewing Terrace at the Argentine Continental Margin north and south of the Mar del Plata Canyon, respectively. The study area is influenced by the Brazil-Malvinas Confluence, where major counterflowing ocean currents affect sedimentation, and northward flowing currents form a large contourite depositional system. Using an existing seismo-stratigraphy, the onset of SD-N was dated to the middle Miocene (∼15–17 Ma), whereas SD-S started developing at the Miocene/Pliocene boundary (∼6 Ma). Acoustic anomalies indicate the presence of gas and diffuse upward fluid migration, and therefore seafloor seepage is proposed as the initial mechanism for SD-S, whereas we consider a structural control for SD-N to be most likely. Initial depressions were reworked and maintained by strong and variable bottom currents, resulting in prograding clinoform reflection patterns (SD-N) or leading to the build-up of extensive cut-and-fill structures (SD-S). Altogether, this study highlights the evolution of two unique and complex seafloor depressions throughout the geologic past under intense and variable bottom current activity in a highly dynamic oceanographic setting.
Thermodynamic analysis of the difference in adsorption characteristics of CH4 and CO2 on continental shale
Authors: Xue Pei , Liang Quansheng , Gao Chao , Yin Jintao , Hao Shiyan , Zhao Qianping 
Published: February 2023

In order to explain the difference in adsorption characteristics of CH4 and CO2 on continental shale from the perspective of thermodynamics, the isothermal adsorption experiments of CH4 and CO2 adsorbed by shale in Yanchang Formation in Ordos Basin were carried out, and the excess adsorption capacity was corrected to absolute adsorption capacity. Then the Clausius-Clapeyron equation was used to analyze the isosteric heat of adsorption of CH4 and CO2 on shale. The results show that, for calculating the absolute adsorption capacity, Ozawa empirical formula or Van der Waals approximation method should be used to calculate the adsorption phase density. The absolute adsorption capacity should be selected as the basic data for calculating the isosteric heat of adsorption. The reason is that the excess isosteric heat of adsorption has a negative value in the low adsorption capacity stage, which is contradictory to the fact that the adsorption process is exothermic, and is significantly higher than the absolute isosteric heat of adsorption. There is a good linear positive correlation between the isosteric heat of adsorption and the adsorption amount of CH4 and CO2 adsorbed by continental shale, and the isosteric heat of adsorption of CH4 is greater than that of CO2. The absolute initial isosteric heat of adsorption of CH4 and CO2 adsorbed by shale is 52.04 kJ/mol and 27.71 kJ/mol, indicating that the adsorption force of CH4 on Yanchang Formation shale is stronger than that of CO2.
Clinical features, risk factors, diagnosis, and treatment of trimethoprim-sulfamethoxazole-induced hypoglycemia
Authors: Wang Chunjiang , Fang Weijin , Li Zuojun , Sun Linli 
Published: February 2023

ObjectiveHypoglycemia is a sporadic and serious adverse reaction of trimethoprim-sulfamethoxazole (TMP-SMX) due to its sulfonylurea-like effect. This study explored the clinical characteristics, risk factors, treatment, and prognosis of TMP-SMX-induced hypoglycemia.MethodsCase reports and series of TMP-SMX-induced hypoglycemia were systematically searched using Chinese and English databases. Primary patient and clinical information were extracted for analysis.ResultsA total of 34 patients were reported from 31 studies (16 males and 18 females). The patients had a median age of 64 years (range 0.4-91), and 75.8% had renal dysfunction. The median duration of a hypoglycemic episode was six days (range 1-20), and the median minimum glucose was 28.8 mg/dL (range 12-60). Thirty-two patients (97.0%) showed neuroglycopenic symptoms, with consciousness disturbance (30.3%) and seizure (24.2%), sweating (18.2%), confusion (15.2%), asthenia (12.1%) being the most common symptoms. Fifteen patients (44.1%) had elevated serum insulin levels, with a median of 31.8 μU/mL (range 3-115.3). C-peptide increased in 13 patients (38.2%), with a median of 7.7 ng/mL (range 2.2-20). Complete recovery from symptoms occurred in 88.2% of patients without sequelae. The duration of hypoglycemia symptoms was 8 hours to 47 days after the intervention. Interventions included discontinuation of TMP-SMX, intravenous glucose, glucagon, and octreotide.ConclusionHypoglycemia is a rare and serious adverse effect of TMP-SMX. Physicians should be aware of this potential adverse effect, especially in patients with renal insufficiency, increased drug doses, and malnutrition.
Association of blood lead with estradiol and sex hormone-binding globulin in 8-19-year-old children and adolescents
Authors: Pan Kaiyu , Tu Rongliang , Cai Zixiu , Huang Yingdan , Zhang Chengyue 
Published: February 2023

BackgroundMetals can interfere with hormonal functioning through indirect mechanisms and by binding at the receptor site; thus, they may be associated with hormonal changes. However, there have been few studies on the health impact of metal exposure among children and adolescents. Thus, we aimed to examine the associations of blood lead level (BLL) with estradiol (E2) and sex hormone-binding globulin (SHBG) among children and adolescents aged 8–19 years in the National Health and Nutrition Examination Survey (NHANES) database.MethodsThis was a cohort study of 2188 individuals from the NHANES. BLL was taken as independent variables, E2 and SHBG as dependent variable. We conducted weighted multivariate linear regression models and smooth curve fittings to evaluate the association between them.ResultsThe BLL was significantly positively associated with serum SHBG level in females, especially when the LnBLL quartiles are between Q3 and Q4. There was an inverted U-shaped association between BLL and E2 with the point of inflection at 1.86 μg/L and a U-shaped association between BLL and SHBG with the point of inflection at 1.86 μg/L in female adolescents aged 16-19 years. Meanwhile, In males, there was a positive trend of correlation between BLL and E2 in the 8-11 years, and 16-19 years groups.ConclusionsThis study found an inverted U-shaped association of BLL with E2 and a U-shaped association between BLL and SHBG in female adolescents aged 16-19 years. This indicates that adjusting blood lead exposure to mitigate the effects of lead on growth and development is important for adolescents aged 16-19 years. Controlling the BLL below 1.86 μg/L may minimize the damage to E2.
Assessment of readiness of a traffic environment for autonomous delivery robots
Authors: Arntz E. M. , Van Duin J. H. R. , Van Binsbergen A. J. , Tavasszy L. A. , Klein T. 
Published: February 2023

Introduction: Autonomous delivery robots are a promising alternative for last-mile delivery. To realise successful implementation of delivery robots in public spaces, it is important to study the interaction between robots and the traffic environment. The traffic environment includes the physical infrastructure and the objects using it like cars and people.Methods: This research proposes an assessment method to determine the readiness of a traffic environment for autonomous delivery robots. A conceptual model is proposed that includes the factors that determine this so-called “roboreadiness”. The two key components of the model are the performance of the robot in the traffic environment and its social acceptance. A real-life experimental test case, expert interviews, and a survey are used to refine and validate the framework.Results: The real-life test case showed for the basic variant a sufficient level both on performance and social acceptance. All other variants such as pillars, road narrowing, and bends did not lead to sufficient performance or social acceptance levels.Discussion: The main outcome of this research is an assessment framework which allows to quantitatively assess traffic performance and social acceptance of sidewalk automated delivery robots. Suggestions for future work include further detailing and elaboration of the approach, scaling up experiments, and researching the possible influence of social acceptance on traffic performance.
Integrated single-cell multiomics reveals novel immune candidate markers for post-traumatic coagulopathy
Authors: Zheng Ping , Zhang Ning , Ren Dabin , Yu Cong , Zhao Bin , Bai Qingke , Zhang Yisong , Sun Wanju 
Published: February 2023

IntroductionPost-traumatic coagulopathy (PTC) is a critical pathology in traumatic brain injury (TBI), however, its potential mechanism is not clear. To explore this in peripheral samples, we integrated single cell RNA-sequencing and T cell repertoire (TCR)-sequencing across a cohort of patients with TBI.MethodsClinical samples from patients with more brain severity demonstrated overexpression of T cell receptor–encoding genes and less TCR diversity.ResultsBy mapping TCR clonality, we found patients with PTC have less TCR clones, and the TCR clones are mainly distributed in cytotoxic effector CD8+T cell. In addition, the counts of CD8+ T cell and natural killer (NK) cells are associated with the coagulation parameter by WGCNA, and the granzyme and lectin-like receptor profiles are also decreased in the peripheral blood from TBI patients, suggesting that reduced peripheral CD8+ clonality and cytotoxic profiles may be involved in PTC after TBI.ConclusionOur work systematically revealed the critical immune status in PTC patients at the single-cell level.
A beacon in the dark: COVID-19 course in CVID patients from two European countries: Different approaches, similar outcomes
Authors: Milito Cinzia , Firinu Davide , Bez Patrick , Villa Annalisa , Punziano Alessandra , Lagnese Gianluca , Costanzo Giulia , van Leeuwen Leanne P. M. , Piazza Beatrice , Deiana Carla Maria , d’Ippolito Giancarlo , Del Giacco Stefano Renato , Rattazzi Marcello , Spadaro Giuseppe , Quinti Isabella , Scarpa Riccardo , Dalm Virgil A. S. H. , Cinetto Francesco 
Published: February 2023

BackgroundCVID patients present an increased risk of prolonged SARS-CoV-2 infection and re-infection and a higher COVID-19-related morbidity and mortality compared to the general population. Since 2021, different therapeutic and prophylactic strategies have been employed in vulnerable groups (vaccination, SARS-CoV-2 monoclonal antibodies and antivirals). The impact of treatments over the last 2 years has not been explored in international studies considering the emergence of viral variants and different management between countries.MethodsA multicenter retrospective/prospective real-life study comparing the prevalence and outcomes of SARS-CoV-2 infection between a CVID cohort from four Italian Centers (IT-C) and one cohort from the Netherlands (NL-C), recruiting 773 patients.Results329 of 773 CVID patients were found positive for SARS-CoV-2 infection between March 1st, 2020 and September 1st 2022. The proportion of CVID patients infected was comparable in both national sub-cohorts. During all waves, chronic lung disease, “complicated” phenotype, chronic immunosuppressive treatment and cardiovascular comorbidities impacted on hospitalization, whereas risk factors for mortality were older age, chronic lung disease, and bacterial superinfections. IT-C patients were significantly more often treated, both with antivirals and mAbs, than NL-C patients. Outpatient treatment, available only in Italy, started from the Delta wave. Despite this, no significant difference was found for COVID-19 severity between the two cohorts. However, pooling together specific SARS-CoV-2 outpatient treatments (mAbs and antivirals), we found a significant effect on the risk of hospitalization starting from Delta wave. Vaccination with ≥ 3 doses shortened RT-PCR positivity, with an additional effect only in patients receiving antivirals.ConclusionsThe two sub-cohorts had similar COVID-19 outcomes despite different treatment approaches. This points out that specific treatment should now be reserved for selected subgroups of CVID patients, based on pre-existing conditions.
Fractionation of toxic metal Pb from truly dissolved and colloidal phases of seaward rivers in a coastal delta
Authors: Ren Peng , Schmidt Bjorn V. , Liu Qun , Wang Shuzhen , Liu Xinyan , Liu Kai , Shi Dalei 
Published: February 2023

Colloids of natural river water is a key intermediate carrier of lead (Pb). It is important to monitor the transport–transformation behavior of Pb in the colloidal phase of seaward water because this behavior is related to the levels of pollution input and environmental risks posed to the sea, especially in coastal delta areas. In this study, the fractionation behavior and distribution of toxic Pb from the truly dissolved phase and the different colloidal phases in seven seaward rivers in the Yellow River Delta were investigated. The concentrations of total dissolved Pb, truly dissolved Pb, and colloidal Pb were 0.99–40.09 μg L–1, 0.40–8.10 μg L–1, and 0.60–35.88 μg L–1, respectively. In freshwater rivers, the main component of total dissolved Pb (about &gt; 50%) is truly dissolved Pb but the main component of total dissolved Pb in the seawater environment is colloidal Pb (&gt; 80%). A dramatic increase in salinity causes the deposition (about ≈94%) of all forms of Pb to sediment from estuarine water in winter. However, this sedimentation behavior of colloidal Pb gradually decreases (in the Shenxiangou River) when the river salinity approaches seawater salinity (S = ≈29). In the industrial port (Xiaoqinghe River) and mariculture (Yongfenghe River) estuarine areas, which have extensive seawater, the deposition behavior of colloidal Pb (&lt;15%) is less affected by the change in salinity. This suggests that human activity contributes to the spread of Pb in the offshore environment. The concentration of 100 kDa–0.22 μm Pb has a postive correlation with total colloidal Pb. Its variation is minimally affected by salinity compared with other colloidal components. In addition, the correlation between the molecular weight and aromaticity of chromophoric dissolved organic matter (CDOM) and colloidal Pb suggests that macromolecules in seawater will be important transport carriers of Pb. In all, truly dissolved Pb is the main transport form of dissolved Pb in river freshwater; however, in brackish water in estuaries, colloidal matter gradually becomes the main transport carrier. Surging salinity immobilizes truly dissolved Pb in the estuarine region, but colloidal matter inhibits this deposition. Colloidal phase is the important conversion for land–sea transport of Pb by seaward rivers.
Surfactant-Assisted Synthesis of NiO-ZnO and NiO-CuO Nanocomposites for Enhanced Photocatalytic Degradation of Methylene Blue Under UV Light Irradiation
Authors: Weldekirstos Hulugirgesh Degefu , Habtewold Birtukan , Kabtamu Daniel Manaye 
Published: February 2023

The photocatalytic process over semiconducting oxide surfaces has attracted worldwide attention as a potentially efficient, environmentally friendly, and low-cost method for wastewater treatment. This study presents a straightforward, inexpensive, and rapid route for the synthesis of nickel oxide (NiO) and its composites with zinc oxide (NiO/ZnO) and copper oxide (NiO/CuO) nanoparticles through the chemical precipitation method using capping agent-hexadecyltrimethylammonium bromide (CTAB) for photocatalytic degradation of the methylene blue dye. The structure, morphology, and elemental constituents were characterized by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The energy band gap of pure NiO, NiO-ZnO, and NiO-CuO composites was evaluated using the Tauc plot from absorption spectra and resulted as 3.00, 2.90, and 3.25 eV, respectively. The optimum parameters for all photocatalysts were the following: pH 8, irradiation time 175 min, catalyst amount 75 mg, and dye concentration 7 mg/L. At these optimum parameters, the degradation efficiency of the prepared photocatalysts toward the MB dye achieved was 89.8% for NiO, 97% for NiO/ZnO, and 94.2% for NiO/CuO. The highest activity of the p-type/n-type (NiO/ZnO) nanocomposite for MB degradation is possibly due to electron–hole pair recombination inhibition by charge transfer processes. Therefore, semiconducting composite-based nanocatalysts such as NiO/ZnO with high photocatalytic activity are promising for future industrial applications to remove undesirable organic pollutants from the environment.
Sb-doped Tl8.67 Sn1.33-xSbx Te6 nanoparticles improve power factor and electronic charge transport
Authors: Khan Sabir , Shah Wiqar H. , Tufail M. , Ali Akhtar , Eldin Sayed M. , Imran Naveed , Sohail Muhammad 
Published: February 2023

Thallium telluride Tl8.67 Sn1.33-xSbxTe6 nano compound doped with different concentration ratios of Sb (x = 0.63, 0.65, 0.66, 0.68, 0.70, or 0.72) was prepared using solid-state techniques, and the compound was heated up to 550 K in vacuum silica tubes. The structure of the nano system was studied using XRD and EDX. It was confirmed that, without any other impurities, the nano system had a single-phase tetragonal crystal structure. The measured Seebeck coefficient (S) of all nano compounds showed that S increased with increase in temperature from 300 to 550 K. S was positive at all temperatures, showing characteristics of a p-type semiconductor. The complex behaviour of S in an Sb-doped nano system showed that at low temperature (room temperature), S first decreased with an increase in Sb concentration up to x = 0.65 and then increased with an increase in the Sb dopant up to x = 0.72. Similarly, electrical conductivity (σ) decreased with an increase in temperature, and the power factor showed complex behaviour relative to Sb concentration. The power factor observed for Tl8.67 Sn1.33-xSbx Te6 nano compound increased with an increase in temperature, within a temperature range of 300–550 K. Tellurides are semiconductors of very narrow band-gap, with component elements in common oxidation states, according to (Tl+9) (Sb3+) (Te2-)6. The phase range was also assessed, and results demonstrated that different Sb dopant ratios were associated with differences in properties (e.g., electrical, thermal, and Seebeck effect) and hence variation in power factor. These results indicate a route through which the thermoelectric characteristics of Tl8.67 Sn1.33-xSbxTe6-based nano materials were harnessed for the development of thermoelectric and electronic applications.
Multimodal Imaging-Based Phenotyping of a Singaporean Hospital-Based Cohort of High Myopia Patients
Authors: Tey Kai Yuan , Hoang Quan V. , Loh Isabella Q. , Dan Yee Shan , Wong Qiu Ying , Yu Daryle Jason G. , Yandri Vivi R. , Ang Marcus , Cheung Gemmy C. M. , Lee Shu Yen , Wong Tien Yin ,   SNEC Retina Group, Chong Rachel S. , Wong Chee Wai 
Published: February 2023

Purpose: To assess the effect of axial length (AL) on the prevalence of pathologic myopia (PM) and associated myopic features in a Singaporean hospital-based cohort of patient with high myopia (HM).Methods: In total, 923 HM eyes from 495 individuals were recruited from the Myopic and Pathologic Eyes in Singapore (MyoPES) cohort and underwent ocular biometry, fundus photography, fundus autofluorescence, and swept-source optical coherence tomography (SS-OCT). Images were analyzed for the presence of myopic macular degeneration (MMD), myopic choroidal neovascularization (mCNV), myopic traction maculopathy (MTM), peripapillary atrophy (PPA), myopic tilted disc, posterior staphyloma (PS), dome-shaped macula (DSM), vitremacular adhesions (VMA), and the epiretinal membrane (ERM). Eyes were stratified into quartiles based on ALs to determine cut-off values to perform comparisons between shorter-length and longer-length groups. A χ2-test was done to determine the difference in the prevalence of pathologies between groups.Results: Overall, mean AL was 29.2 ± 2.2 mm (range 25.0–36.7 mm). Myopic macular degeneration, PPA, myopic tilted disc, and ERM have AL threshold of ≥27.5 mm, whereas MTM has an AL threshold of ≥29.0 mm. We found that there was a significantly higher prevalence of MMD (88.2 vs. 49.4%; p &lt; 0.001), PPA (98.1 vs. 80.1%; p &lt; 0.001), myopic tilted disc (72.7 vs. 50.2%; p &lt; 0.001), and ERM (81.4 vs. 17.3%; p = 0.003) in eyes with AL ≥ 27.5 mm vs. eyes without AL &lt;27.5 mm. Prevalence of MTM (34.7 vs. 32.1%; p &lt; 0.001), mCNV (17.4 vs. 12.1%; p = 0.03), PS (43.4 vs. 34.7%; p = 0.012), DSM (21.3 vs. 13.2%; p = 0.002), and VMA (5.9 vs. 2.6%; p = 0.014) in eyes with AL ≥ 29.0 mm compared with AL &lt; 29.0 mm.Conclusion: Our study describes the overall prevalence of PM and related pathologies among patients with HM in our hospital-based cohort. Longer eyes even among HM eyes had a significantly higher prevalence of PM-associated pathologies studied. This supports the premise that eyes with longer AL, even among HM eyes may be at greater risk of vision-threatening changes and therefore merit regular follow-up.