bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surveillance as information practice
Authors: Newell Bryce Clayton 
Published: January 2023

AbstractSurveillance, as a concept and social practice, is inextricably linked toinformation. It is, at its core, about information extraction and analysis conducted for some regulatory purpose. Yet, information science research only sporadically leverages surveillance studies scholarship, and we see a lack of sustained and focused attention tosurveillanceas an object of research within the domains of information behavior and social informatics. Surveillance, as a range of contextual and culturally based social practices defined by their connections to information seeking and use, should be framed asinformation practice—as that term is used within information behavior scholarship. Similarly, manifestations of surveillance in society are frequently perfect examples of information and communications technologies situated within everyday social and organizational structures—the very focus of social informatics research. The technological infrastructures and material artifacts of surveillance practice—surveillance technologies—can also be viewed asinformation tools. Framing surveillance as information practice and conceptualizing surveillance technologies as socially and contextually situated information tools can provide space for new avenues of research within the information sciences, especially within information disciplines that focus their attention on the social aspects of information and information technologies in society.
Life is either a daring adventure, or it is boring: The impact of COVID‐19 on immoral and nonmoral risk taking behaviors
Authors: Li Heng 
Published: January 2023

AbstractFindings from correlational research suggest that people more likely to take risk during COVID‐19. However, little is known about the causal role of the coronavirus threat in the emergence of risk taking behaviors. Here, we conducted three diverse studies involving questionnaire‐based responses and actual measures of risk‐taking behavior across nonmoral and immoral domains. In support of our theoretical perspective, Experiment 1 revealed that participants who were exposed to the COVID‐19 threat were more prone to take risks than those in the control condition. Experiment 2 aimed to replicate the findings of Experiment 1 using a behavioral measure to capture participants' interest in risk taking. The results showed that the salience of COVID‐19 can increase individuals' willingness to take risks in a nonmoral domain, namely, bungee jumping. Experiment 3 provided a behavioral confirmation of the relationship uncovered in an immoral domain (i.e., bribery). Across three experiments, we found that boredom state mediated the effect of the pandemic influence on risk taking. Together, our research rounds out the picture of contributors to risk taking and underscores the cumulative destructive effect of COVID‐19. We discuss implications for research on COVID‐19 and risk taking, as well as practical significance for society at large.
Green creativity, responsible innovation, and product innovation performance: A study of entrepreneurial firms in an emerging economy
Authors: Adomako Samuel , Nguyen Nguyen Phong 
Published: January 2023

AbstractIn this article, we investigate the effect of green creativity on product innovation performance through the mediating mechanism of responsible innovation. Further, we explore the moderating impact of resource commitment on the relationship between green creativity and responsible innovation. Utilizing a sample of 273 entrepreneurial firms in Vietnam, we find that green creativity positively influences responsible innovation. In addition, the results demonstrate that the effect of green creativity on responsible innovation is moderated by a firm's level of resource commitment to environmental innovation, such that the effect is more pronounced when a firm commits more resources to environmental innovation. Finally, we find the effect of green creativity on product innovation performance is mediated by responsible innovation. The theoretical as well as practical implications of the findings are discussed.
Outcomes associated with allogeneic hematopoietic stem cell transplantation for relapsed and refractory Hodgkin lymphoma in the era of novel agents
Authors: Faisal Muhammad Salman , Hanel Walter , Voorhees Timothy , Li Rui , Huang Ying , Khan Abdullah , Bond David , Sawalha Yazeed , Reneau John , Alinari Lapo , Baiocchi Robert , Christian Beth , Maddocks Kami , Efebera Yvonne , Penza Sam , Saad Ayman , Brammer Jonathan , DeLima Marcos , Jaglowski Samantha , Epperla Narendranath 
Published: January 2023

AbstractBackgroundRelapsed or refractory Hodgkin lymphoma (R/R HL) is a challenging disease with limited treatment options beyond brentuximab vedotin and checkpoint inhibitors. Herein we present the time‐trend analysis of R/R HL patients who received allogeneic hematopoietic cell transplantation (allo‐HCT) at our center from 2001–2017.MethodsThe patients were divided into two distinct treatment cohorts: era1 (2001–2010), and era2 (2011–2017). The primary endpoint was overall survival (OS). Secondary endpoints included progression‐free survival (PFS), non‐relapse mortality (NRM), and cumulative incidence of acute and chronic graft versus host disease (GVHD).ResultsAmong the 51 patients included in the study, 29 were in era1, and 22 were in era2. There was decreased use of myeloablative conditioning in era2 (18% vs. 31%) compared to era1 and 95% of patients in era2 previously received brentuximab Vedotin (BV). Haploidentical donors were seen exclusively in era2 (0% vs. 14%) and more patients received alternative donor transplants (7% vs. 32%) in era2. The 4‐year OS (34% vs. 83%, p < 0.001) and 4‐year PFS (28% vs. 62%, p = 0.001) were significantly inferior in era1 compared to era2. The incidence of 1‐year NRM was lower in era2 compared to era1 (5% vs. 34%, p = 0.06). The cumulative incidence of acute GVHD at day 100 was similar in both eras (p = 0.50), but the incidence of chronic GVHD at 1 year was higher in era2 compared to era1 (55% vs. 21%, p = 0.03).ConclusionsDespite the advent of novel therapies, allo‐HCT remains an important therapeutic option for patients with R/R HL.
Prediction of surfactin fermentation with Bacillus subtilis DSM10 by response surface methodology optimized artificial neural network
Authors: Czinkóczky Réka , Sakiyo Jesse , Eszterbauer Edina , Németh Áron 
Published: January 2023

AbstractBiosurfactants produced by Bacillus species are an emerging group of surface‐active molecules. They have excellent surface tension reducer and high emulsifier properties. Generally, the biosurfactant fermentation leads to a low product concentration. Therefore, our goal was to investigate Bacillus subtilis DSM10 production and improve the biosurfactant content in the broth by media optimization via response surface methodology. The optimal combinations of the investigated factors were determined as the following: pH = 9, glucose = 20 g/L, and NH4NO3 = 2 g/L. Under the optimized conditions, the formed surfactin strain reduced surface tension in the broth by 48% (from 72 to 37 mN/m) and the isolated product by 63% (from 72 to 27 mN/m). An artificial neural network was built based on the results of response surface methodology to predict the product quality and the harvesting time of broth. Thus, finally, the model can predict the final cell and product amount, and even their time course, with around 90% reliability.
BMI and the mortality paradox in patients undergoing cardiovascular procedures—Causation or Association?
Authors: Sharifeh Tareq Abu , Jneid Hani 
Published: January 2023

Key Points
There is limited evidence on the relationship between body mass index (BMI) and mortality risk in cardiac patients in the contemporary era of invasive cardiology.
In the current observational analysis from the multicenter KARDIO registry (2012–18), BMI was non‐linearly associated with long‐term mortality. After multivariable adjustment, underweight (<18.5 kg/m2) and obesity class III (BMI >40 kg/m2) were associated with increased hazards of all‐cause mortality at a median follow‐up of 4.9 years.
Clinicians should be vigilant about the obesity paradox in patients undergoing invasive cardiology procedures, and factor them in as they deliberate appropriateness and indications of the procedures.
Bilateral non‐contiguous necrotizing fasciitis of the lower extremities
Authors: Bender Sascha T. , Ganz Maximilian , Mertens Peter R. , Gross Christian 
Published: January 2023

AbstractNecrotizing fasciitis (NF) is an uncommon soft tissue infection. Multifocal‐extremity NF is a rarity with high mortality rates. Herein we report a case of bilateral non‐contiguous NF of the lower extremities due to Escherichia coli with a fatal outcome, stressing the necessity of rapid and aggressive intervention in suspected cases.
Diversity‐Oriented Synthesis (DOS) of On‐DNA Peptidomimetics from Acid‐Derived Phosphonium Ylides
Authors: Krishna Sunkari Yashoda , Kumar Siripuram Vijay , Flajolet Marc 
Published: January 2023

AbstractThe DNA‐encoded library (DEL) technology represents a revolutionary drug‐discovery tool with unprecedented screening power originating from the association of combinatorial chemistry and DNA barcoding. The chemical diversity of DELs and its chemical space will be further expanded as new DNA‐compatible reactions are introduced. This work introduces the use of DOS in the context of on‐DNA peptidomimetics. Wittig olefination of aspartic acid‐derived on‐DNA Wittig ylide, combined with a broad substrate scope of aldehydes, led to formation of on‐DNA,‐unsaturated ketones. The synthesis of on‐DNA multi‐peptidyl‐ylides was performed by incorporating sequential amino acids onto a monomeric ylide. Di‐, tri‐ and tetrameric peptidyl‐ylides were validated for Wittig olefination and led to on‐DNA,‐unsaturated‐based peptidomimetics, an important class of intermediates. One on‐DNA aryl Wittig ylide was also developed and applied to Wittig olefination for synthesis of on‐DNA chalcone‐based molecules. Furthermore, DOS was used successfully with electron‐deficient peptidomimetics and led to the development of different heterocyclic cores containing on‐DNA peptidomimetics.
Large‐Area Uniaxially Oriented Sub‐5 nm Line Patterns of Hybrid Liquid Crystals Constructed by Perylene Diimide and Oligo(Dimethylsiloxane)
Authors: Yang Weilu , Liu Dong , Liu Yun , Yang Shichu , Liu Yadi , Shen Zhihao , Yang Huai , Fan Xing‐He , Zhou Qi‐Feng 
Published: January 2023

AbstractConstruction of sub‐5 nm long‐range ordered structures through self‐assembly has received increasing attention. Herein, a series of ODMS‐based thermotropic liquid crystals (LCs) containing perylene diimide (PDI) were designed and synthesized. These LCs can form ordered nanostructures with periodic sizes around 5 nm including smectic J (SmJ), oblique columnar (Colob), and hexagonal columnar (Colh) phases with change in the volume fraction of ODMS, where the layer spacing of the SmJ phase is less than 5 nm. Thin films with parallel oriented nanolines with line width less than 5 nm can be obtained on PDMS‐modified silicon substrates by spin‐casting and simple thermal annealing processes. Moreover, owing to the strong π‐π interaction between PDI cores, these nanolines are long‐range ordered with uniaxial orientation in relatively large areas (1.5×1.5 μm2) with over 300 continuous microdomains without pre‐patterning. These nanostructures provide the possibility of preparing nanotemplates by oxygen plasma etching.
A knockout‐first model of H3f3a gene targeting leads to developmental lethality
Authors: Bush Kelly , Cervantes Vanessa , Yee Jennifer Q. , Klein Rachel H. , Knoepfler Paul S. 
Published: January 2023

SummaryHistone variant H3.3 is encoded by two genes, H3f3a and H3f3b, which can be expressed differentially depending on tissue type. Previous work in our lab has shown that knockout of H3f3b causes some neonatal lethality and infertility in mice, and chromosomal defects in mouse embryonic fibroblasts (MEFs). Studies of H3f3a and H3f3b null mice by others have produced generally similar phenotypes to what we found in our H3f3b nulls, but the relative impacts of the loss of either H3f3a or H3f3b have varied depending on the approach and genetic background. Here we used a knockout‐first approach to target the H3f3a gene for inactivation in C57BL6 mice. Homozygous H3f3a targeting produced a lethal phenotype at or before birth. E13.5 null embryos had some potential morphological differences from WT littermates including smaller size and reduced head size. An E18.5 null embryo was smaller than its control littermates with several potential defects including small head and brain size as well as small lungs, which would be consistent with a late gestation lethal phenotype. Despite a reduction in H3.3 and total H3 protein levels, the only histone H3 post‐translational modification in the small panel assessed that was significantly altered was the unique H3.3 mark phospho‐Serine31, which was consistently increased in null neurospheres. H3f3a null neurospheres also exhibited consistent gene expression changes including in protocadherins. Overall, our findings are consistent with the model that there are differential, cell‐type‐specific contributions of H3f3a and H3f3b to H3.3 functions in epigenetic and developmental processes.
The best colleges for adult learners never stop working to improve
Authors: Sutton Halley 
Published: January 2023

“I'm a farm kid. I grew up in a small town in Nebraska — there were a whopping 1,000 people in my town,” said Jerrid P. Freeman, Ph.D., Vice President for Student Affairs and Enrollment Management at Northeastern State University in Oklahoma. “It was one of those things where college was just not on my radar.” Freeman pursued his undergraduate degree at the University of Nebraska at Kearney while playing sports, and came to love the higher education environment, going on to earn his master's and doctorate.
Follow the science: The European public health community confronts the first wave of the COVID‐19 pandemic
Authors: Kurzer Paulette , Ornston Darius 
Published: January 2023

AbstractThis paper argues that “following the science” is not always the best strategy. It does so by examining the first phase of the coronavirus disease 2019 (COVID‐19) pandemic in three countries: Denmark, the Netherlands, and Sweden. All three countries possessed highly respected infectious disease agencies with wide stakeholder involvement. Despite this, Danish, Dutch, and Swedish public health agencies underplayed the threat of the COVID‐19 virus, discouraged intrusive mitigation measures, and were slow to admit their mistakes. Countries that trusted their national agencies, specifically the Netherlands and Sweden, witnessed higher mortality. By contrast, the Danish government marginalized its epidemiologists and suppressed the spread of the virus. The paper thus demonstrates the limits of trusting national scientific expertise, even when properly embedded within social networks, during periods of heightened uncertainty.
PINK1 siRNA‐loaded poly(lactic‐co‐glycolic acid) nanoparticles provide neuroprotection in a mouse model of photothrombosis‐induced ischemic stroke
Authors: Choi Seung Gyu , Shin Juhee , Lee Ka Young , Park Hyewon , Kim Song I. , Yi Yoon Young , Kim Dong Woon , Song Hee‐Jung , Shin Hyo Jung 
Published: January 2023

AbstractPTEN‐induced kinase 1 (PINK1) is a well‐known critical marker in the pathway for mitophagy regulation as well as mitochondrial dysfunction. Evidence suggests that mitochondrial dynamics and mitophagy flux play an important role in the development of brain damage from stroke pathogenesis. In this study, we propose a treatment strategy using nanoparticles that can control PINK1. We used a murine photothrombotic ischemic stroke (PTS) model in which clogging of blood vessels is induced with Rose Bengal (RB) to cause brain damage. We targeted PINK1 with poly(lactic‐co‐glycolic acid) (PLGA)‐based nanoparticles loaded with PINK1 siRNA (PINK1 NPs). After characterizing siRNA loading in the nanoparticles, we assessed the efficacy of PINK1 NPs in mice with PTS using immunohistochemistry, 1% 2,3,5‐triphenyltetrazolium chloride staining, measurement of motor dysfunction, and Western blot. PINK1 was highly expressed in microglia 24 h after PTS induction. PINK1 siRNA treatment increased phagocytic activity, migration, and expression of an anti‐inflammatory state in microglia. In addition, the PLGA nanoparticles were selectively taken up by microglia and specifically regulated PINK1 expression in those cells. Treatment with PINK1 NPs prior to stroke induction reduced expression of mitophagy‐inducing factors, infarct volume, and motor dysfunction in mice with photothrombotic ischemia. Experiments with PINK1‐knockout mice and microglia depletion with PLX3397 confirmed a decrease in stroke‐induced infarct volume and behavioral dysfunction. Application of nanoparticles for PINK1 inhibition attenuates RB‐induced photothrombotic ischemic injury by inhibiting microglia responses, suggesting that a nanomedical approach targeting the PINK1 pathway may provide a therapeutic avenue for stroke treatment.
Driving following a diagnosis of dementia: Exploring the views and experiences of people with dementia—A UK survey
Authors: Gouldsborough Victoria , Fairmichael Fergus , Davison Christopher , Hetherington Victoria , Barber Robert 
Published: January 2023

AbstractBackgroundDriving cessation can be one of the adjustments made following a diagnosis of dementia. Little is known about the views and opinions of people living with dementia about this. The study aimed to gather a broad idea of the expectations, impacts and the process of driving cessation from the perspective of those living with dementia.Methods138 people with dementia and 91 relatives/friends (on behalf of an individual with dementia) took part in an online questionnaire.ResultsPeople living with dementia reported stopping driving following diagnosis can have negative psychological impacts particularly in relation to; feelings of isolation, depression, loss of freedom and feeling life isn’t worth living. Age, gender and choice in the driving cessation process were related to the degree of negative experiences.ConclusionsThe difficulties reported by people with dementia suggest a need to provide more structured post diagnostic support to aid decision making of driving continuation or cessation; with the view to reducing associated distress and enabling people with dementia to continue to live a meaningful life.
Activity‐Based Protein Profiling of Oxidases and Reductases
Authors: Krammer Leo , Breinbauer Rolf 
Published: January 2023

AbstractActivity‐based protein profiling (ABPP) as a proteomic tool allows measuring the activity of enzyme classes or distinct proteins in their cellular context, annotating the function of uncharacterized proteins, and investigating the target profile of small molecule inhibitors. While hydrolases and other enzyme classes, which exhibit a characteristic nucleophilic residue, can be addressed by electrophilic activity‐based probes, the large enzyme class of oxidoreductases has received much less attention in ABPP. In this review the state of the art of ABPP of oxidases is presented. The most frequent principle in ABPP for oxidases is the oxidative activation of the ABPP probe leading to an electrophilic group as exemplified for alkyne or amine based warheads. Alternatively, in rare cases ABPP probes can address characteristic electrophilic or nucleophilic residues of certain oxidases. Most recently, with NQO2 the first example of ABPP for a reductase has been reported.
DNMT3b affects colorectal cancer development by regulating FLI1 through DNA hypermethylation
Authors: Zhou Lei , Pan Li‐Zhen , Fan Yue‐Juan 
Published: January 2023

AbstractFriend leukemia integration 1 (FLI1) is an ETS transcription factor family member. Here, we identified cg11017065 as the most hyper‐methylated cytosine and guanine (CpG) in colorectal cancer (CRC), which belongs to the FLI1 gene. Moreover, integrated bioinformatics prediction and analysis of our cohort showed that FLI1 expression was downregulated and DNA methylation was elevated in CRC. Bioinformatics prediction also indicated that patients overexpressing FLI1 had higher survival rates than those with low FLI1 expression. CRC cells with ectopic expression of FLI1 had reduced invasion, migration, cloning ability and increased apoptosis. Furthermore, DNA‐methyltransferase 3b (DNMT3b) was found to be significantly overexpressed in CRC, and low DNMT3b expression predicted a prolonged survival. DNMT3b bound to the FLI1 promoter. Inhibition of DNMT3b increased FLI1 expression and inhibited the malignant phenotype of CRC cells. Inhibition of FLI1 reversed the phenotypic modulation by DNMT3b depletion in vitro and in vivo. In conclusion, our data indicate that DNMT3b potentiates CRC cell proliferation, migration, and invasion through downregulating FLI1.
Sinonasal complications of severe acute respiratory syndrome coronavirus‐2: A single center case series
Authors: Lee Saangyoung E. , Ghodke Ameer N. , Stepp Wesley H. , Kong Keonho A. , Chaskes Mark , Quinsey Carolyn S. , Ebert Charles S. , Thorp Brian D. , Senior Brent A. , Kimple Adam J. 
Published: January 2023

AbstractBackgroundThe emergence of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has resulted in an unprecedented global pandemic. Most infected patients are either asymptomatic or have mild upper respiratory infection symptoms. However, life‐threatening sequelae have been observed. In this report, we reviewed nine cases of patients with severe complications from sinonasal disease in the setting of acute SARS‐CoV‐2 infection.MethodsIRB approval was obtained prior to study initiation. A retrospective chart review was performed of patients admitted to a tertiary hospital with complex sinonasal symptoms that required otolaryngologic evaluation and management in the setting of concomitant SARS‐CoV‐2 infection.ResultsNine patients, ranging from ages 3 to 71 years, with sinonasal disease and simultaneous SARS‐CoV‐2 infection were identified. Initial presentations ranged from asymptomatic infection to mild/moderate disease (nasal obstruction, cough) or more severe sequelae including epistaxis, proptosis, or neurologic changes. SARS‐CoV‐2 tests were positive from one to 12 days after symptom onset, with three patients receiving SARS‐CoV‐2‐directed treatment. Complex disease presentations included bilateral orbital abscesses, suppurative intracranial infection, cavernous sinus thrombosis with epidural abscess, systemic hematogenous spread with abscess development in four distinct anatomic locations, and hemorrhagic benign adenoidal tissue. Eight of nine patients (88.8%) required operative intervention. Patients with abscesses also required prolonged, culture‐directed antibiotic courses.ConclusionThough most SARS‐CoV‐2 infections are asymptomatic and/or self‐limited, there is significant morbidity and mortality in patients with severe disease sequela as outlined in our reported cases. This suggests early identification and treatment of sinonasal disease in this patient population is critical to minimizing poor outcomes. Further research on the pathophysiology of these atypical presentations is needed.Level of Evidence4 (Case Series).