bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy in postpartum women with breast cancer
Authors: Dou He , Jia Si , Ba Yu , Luo Dan , Yu Ping , Li Fu cheng , Wang You , Chen Xing , Xiao Min 
Published: July 2023

Abstract
Purpose
Breast cancer (BC) is currently the leading cause of death in women worldwide. Studies have confirmed that pregnancy is an independent factor affecting the survival of BC patients. BC found during pregnancy, lactation, or shortly after delivery is what we used to think of as pregnancy-associated breast cancer (PABC). The current expert definition of this concept is not uniform; however, there is growing evidence that postpartum breast cancer (PPBC) differs from other types of BC in terms of both biological features and prognosis, with a slightly different focus on diagnosis and treatment. With the increase of female reproductive age population and changes in fertility policies in China, patients with PPBC are receiving increasing attention. Here, we systematically analyzed the clinicopathological characteristics and chemotherapeutic response of patients with PPBC.
Patients and methods
We retrospectively analyzed the clinicopathological data, molecular subtypes, chemotherapy regimens and pathological complete remission (pCR) rates of 1343 patients with non-metastatic BC at Harbin Medical University Cancer Hospital from January 1, 2012 to May 31, 2023. The categorical data were compared by chi-square test and Fister exact test using logistic regression model. Predictor variables with P < 0.05 in the univariate analysis were included in the multivariate regression analysis to investigate the relationship between different age groups and pCR.
Results
A total of 714 patients were eligible for analysis in this study, and 667 patients had a history of pregnancy, 40 (5.6%) of whom were PPBC patients.
When diagnosed with BC, patients with PPBC were younger, more likely to undergo breast-conserving surgery (BCS), and more likely to achieve pCR (P < 0.05). In molecular typing, human epidermal growth factor receptor 2 (HER-2)-positive and triple-negative breast cancer (TNBC) were more frequent. In the entire cohort, HER-2 expression and delivery status were independent predictors of pCR rates in BC patients after neoadjuvant chemotherapy (NAC).
Conclusion
Our findings suggest that postpartum status is an independent predictor of pCR attainment in BC patients. PPBC is more sensitive to chemotherapy than other patients,We need to pay more attention to this group and achieve individualized treatment, which will help us treat BC better and provide new targets and blueprints for our clinical therapy.
Tuning Photocatalytic Efficiency through Cu Doping in Ni-Zn Ferrite Nanoparticles: Structural and Optical Characteristics
Authors: Bhamare Jyoti D. , Pandit Vishal A. , Chaudhari N.D. 
Published: July 2023

Abstract
In this study, Undoped and Cu-doped Ni0.6-x Zn0.4CuxFe2O4 (x = 0, 0.3) ferrite nanoparticles were synthesized using the sol-gel auto combustion method. The nanoparticles exhibited a single-phase spinel crystal structure as confirmed by XRD analysis. The crystallite sizes were determined to be in the range of 20 to 30 nm. SEM revealed the nanoparticles to have a spherical morphology. EDS confirmed the elemental composition and purity of the nanoparticles. FTIR analysis provided insights into the vibrational modes and bonding characteristics of the nanoparticles. UV-VIS was employed to investigate the optical properties of the nanoparticles, revealing band gap energies ranging from 2.80 to 3.5 eV. The photocatalytic activity of the nanoparticles was evaluated through the degradation of methylene blue under sunlight irradiation, demonstrating their effectiveness as photocatalysts. These findings contribute structural and optical properties of undoped and Cu-doped Ni-Zn ferrite nanoparticles, emphasizing their potential as efficient photocatalysts for environmental applications.
Causal impact of genetically-determined fish and fish oil intake on epigenetic age acceleration and related serum markers
Authors: Fabian Paul , Blander Gil , Deehan Renee , Torkamani Ali , Nogal Bartek 
Published: July 2023

Abstract
Background: The interplay between diet and healthspan is a topic of great interest in biomedical research. Toward this end, consumption of marine omega-3 fatty acids is of particular significance, as reports suggest that diets focused on seafood can prolong the disease-free portion of the human lifespan. Fish consumption has also been linked to reduced biological aging as measured by epigenetic clocks, but there is no conclusive evidence of a causal relationship. Moreover, fish oils reduce triglycerides, and may affect other lipid profiles, as well as systemic inflammation. To investigate further, we used two-sample Mendelian randomization to infer causality between fish intake and healthspan markers.
Methods: We perform bidirectional Mendelian randomization in the two-sample setting using publicly available GWAS summary statistics repositories. Usingoily fish consumption and fish oil supplementation as the primary exposures, we attempt to elucidate the causal landscape of these interventions on first- and second-generation epigenetic clocks as well as serum proxies of lipidemia and systemic inflammation.
Results: We report that oily fish consumption appears to causally modify PhenoAge (p < 0.0074), whereas it begins to approach causality with respect to GrimAge (p = 0.097). However, fish oil supplements do exhibit a causal relationship with GrimAge (p = 0.037). Both omega-3 exposures modify the epigenetic clocks in the expected negative, or age-decelerating, direction. We also confirm the causal relationship between fish oil consumption and triglyceride reduction (p = 0.004), though HDL and LDL were not significantly modified. Finally, we also detect suggestive causality between oily fish consumption and reduced hsCRP (p = 0.062).
Conclusions: Our analysis shows that consuming fish oil, whether through whole food or as a supplement, can have a rejuvenating impact as measured by PhenoAge and GrimAge acceleration. We have also confirmed the causal link between fish oil intake and lower triglyceride levels. These results, based on robust MR-based analyses, emphasize the effectiveness of dietary choices in influencing healthspan.
Effect of Hesperidin on blood pressure and lipid profile: A systematic review and meta-analysis of randomized controlled trials
Authors: Shylaja Hanumanthappa , Viswanatha Gollapalle L , Venkategowda Sunil , Hussain Shalam M. , Farhana Syeda Ayesha 
Published: July 2023

Abstract

Background
The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta-analysis published on this topic in 2019. However, considering the recently published clinical studies there is a scope for performing a systematic review and meta-analysis on the cardioprotective effect of hesperidin. This systematic review and meta-analysis were performed to determine the beneficial effect of hesperidin in alleviating alterations in cardiovascular parameters based on available clinical studies.
Methods
The literature search was performed using online databases such as PubMed and Google Scholar. The search was mainly focused on the role of hesperidin in various cardiovascular disorders.
Results
Based on the inclusion and exclusion criteria 9 clinical studies involving 2414 subjects were included. The meta-analysis revealed that the hesperidin has significantly reduced the systolic blood pressure (Inverse variance (I.V): -0.86 (-1.53 to -0.18) at 95% CI, p = 0.01, I2 = 100%) and total triglycerides (IV: -0.21 (-0.40 to -0.02) at 95% CI, p = 0.03, I2 = 12%). However, there were no statistically significant changes in the diastolic blood pressure (IV: 0.52 (-1.78 to 2.83) at 95% CI, p = 0.06, I2 = 100%), HDL (IV: 0.04 (-0.25 to 0.34) at 95% CI, p = 0.78, I2 = 56%), LDL (IV: -0.10 (-0.66 to 0.45) at 95% CI, p = 0.72, I2 = 85%), and total cholesterol (TC) (IV: 0.18 (-0.79 to 0.44) at 95% CI, p = 0.57, I2 = 88%) compared with the placebo/control.
Conclusion
The outcomes of the meta-analysis suggest that hesperidin administration could benefit patients with cardiovascular diseases by reducing systolic blood pressure and total triglycerides.
A Real-time and High-Performance MobileNet Accelerator based on adaptive dataflow scheduling for Image Classification
Authors: Sang Xiaoting , Ruan Tao , Li Chunlei , Li Huanyu , Yang Ruimin , Liu Zhoufeng 
Published: July 2023

Abstract
Convolutional neural network (CNN) models equipped with depth separable convolution (DSC) promise a lower spatial complexity while retaining high model accuracy. However, little attention has been paid to their hardware architecture. Previous studies on DSC-based CNN accelerators typically use fixed computational models for various models, leading to an imbalance between power, efficiency, and performance. To address this problem, a novel, real-time DSC-based CNN accelerator that can accommodate field-programmable gate arrays (FPGAs) of different capacities and CNNs of different sizes is proposed in this paper. Attractively, a dynamically reconfigurable computing engine and block-convolution-based adaptive dataflow scheduling mode strike a trade-off between hardware resources and the processing speed in industrial processes. The proposed MobileNet accelerator was implemented and evaluated on the Xilinx XC7020 platform. Compared to previous FPGA-based accelerators, the experimental results showed that our approach can provide a frame rate of 29.4 FPS for full HD RGB images, meeting the needs of real industrial real-time applications.
Reactive Handover Coordination System with Regenerative Blockchain Principles for Swarm Unmanned Aerial Vehicles
Authors: Rajasoundaran S. , Kumar S. V.N. Santhosh , M Selvi , Kannan Arputharaj 
Published: July 2023

Abstract
Aerial warfare systems in various countries highly expect Swarm Unmanned Aerial Vehicles (UAVs) and Flying Adhoc Networks (FANETs) for defense stability. However, swarm UAVs face many challenges, like security breaches, malfunctions, link failures, and handover failures. UAVs can easily malfunction by external threats to create data loss, theft, signal jamming, misrouting, false handover, and location spoofing. Failures in UAV handover principles make overall gradual downtime in FANET. Against these issues, existing UAV protection mechanisms deliver location monitoring mechanisms (graphs and trees), multi-link handover mechanisms, and distributed authentication principles. Anyhow, the implantation of recent-day techniques may fail against migrating attacker events executed in electronic warfare systems. The methods need improvements in protecting Multi-UAV layers through end-to-end security principles. On the research problem, the proposed Reactive Handover Coordination System with Regenerative Blockchain Principles (RHCRB) takes novel high-security features specially made for swarm UAVs. RHCRB implements more crucial distributed functions in each UAV on demand. The executed operations of RHCRB comprise trusted location monitoring schemes (internal and cooperative UAV movements), dynamic location-based cost magnitude calculations, regenerative blockchain principles (authentication of each UAV and active edges), confidential link management principles, secure handover coordination, and on-demand topology management principles. The technical aspects of RHCRB build lightweight and shielded handover principles against airfield vulnerabilities. The proposed model suggests implementing an entirely protected handover environment from node localization to handover events. The inspired technical aspects of RHCRB contribute to the swarm UAV environment through confidential (Advanced Encryption Standard (AES)) and distributed authentication (blockchain-based node and edge management) principles to engage protected handover practices. The experimental section of this article has the testbed in FlyNetSim tool for implementing RHCRB and notable recent security techniques such as the Internet of Vehicles with Decentralized Blockchains (IoV-DB), Group Handover for Internet of Defense (GH-IoD), and Handover and Optimized Security Principles for UAVs (HOOPOE). The results show RHCRB's 8–14% of betterment than existing techniques through various measures.
Study on the Mechanism of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen in Sedation and tranquilizing mind
Authors: Zhu Chenghao , Zhang Zhengru , Sun Zhirong 
Published: July 2023

Abstract
Method
The chemical constituents and therapeutic targets of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen were acquired from TCMSP, HERB, and ETCM databases. Active components were identified using ADME criteria, while the primary targets associated with sedation and mental tranquility were obtained from GENECARDS, OMIM, and DRUGBANK databases. To investigate potential functional protein modules within the network, a protein-protein interaction (PPI) network analysis was conducted using the STRING platform. The METASCAPE platform was employed for the analysis of the "component-target" and its associated biological processes and pathways. Subsequently, the construction of the "component-target" network was accomplished using Cytoscape 3.9.1 software. Finally, the validation of molecular docking was conducted through AUTODOCK. Results: The findings revealed that Quercetin, Atropine, dauricine, (S)-Coclaurine, and other active ingredients were identified as the core constituents of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen. Additionally, PTGS2, PTGS1, MAOB, GABRA1, SLC6A2, ADRB2, CHRM1, HTR2A, and other targets were identified as the core targets. The results of the molecular docking analysis demonstrated that Quercetin, dauricine, and (S)-Coclaurine exhibited strong binding affinity towards PTGS2. The predominant biological pathways associated with sedation and tranquilization primarily involved neuroactive ligand-receptor interaction and activation of receptors involved in chemical carcinogenesis. This study provides initial findings on the multi-component, multi-target, and multi-pathway mechanism underlying the sedative and tranquilizing effects of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen. These findings have the potential to serve as a foundation for the future development and utilization of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen.
Early outcome of simplified total arch reconstruction under mild hypothermia (30-32°C) with distal aortic perfusion
Authors: Zheng# Hua-Jie , Liu# Xin , He Ping , Li Jun , Zhang Xian-Pu , Cheng Yong-Bo , Lin De-Qing , Yan Chao-Jun , Yu San-Jiu , Cheng Wei 
Published: July 2023

Abstract
Objective
We designed a simplified total arch reconstruction (s-TAR) technique which could be performed under mild hypothermia (30–32°C) with distal aortic perfusion. This study aimed to compare its efficacy of organ protection with the conventional total arch reconstruction (c-TAR).
Methods
We reviewed the clinical data of 195 patients who had ascending aortic aneurysm with extended aortic arch dilation and underwent simultaneous ascending aorta replacement and TAR procedure between January 2018 and December 2022 in our center. 105 received c-TAR under moderate hypothermia (25–28°C) with circulatory arrest (c-TAR group); rest 90 received s-TAR under mild hypothermia (30–32°C) with distal aortic perfusion (s-TAR group).
Results
The s-TAR group demonstrated shorter CPB time, cross-clamp time and lower body circulatory arrest time compared with the c-TAR group. The 30-day mortality was 2.9% for the c-TAR group and 1.1% for the s-TAR group (P = 0.043). The mean duration of mechanical ventilation was shorter in the s-TAR group. Paraplegia was observed in 4 of 105 patients (3.8%) in the c-TAR group, while no such events were observed in the s-TAR group. The incidence of temporary neurologic dysfunction was significantly higher in the c-TAR group. The incidence of permanent neurologic dysfunction also showed a tendency to be higher in the c-TAR group, without statistical significance. Furthermore, the incidence of reoperation for bleeding were significantly lower in the s-TAR group. The rate of postoperative hepatic dysfunction and all grades of AKI was remarkably lower in the s-TAR group. The 3-year survival rate was 95.6% in the s-TAR group and 91.4% in the c-TAR group.
Conclusions
s-TAR under mild hypothermia (30–32℃) with distal aortic perfusion is associated with lower mortality and morbidity, offering better neurological and visceral organ protection compared with c-TAR.
Structural and mechanical properties of Turkish delight production using fruit and vegetable paste
Authors: Babaiev Serhii , Kasabova Kateryna , Samokhvalova Olga , Shydakova-Kameniuka Olena , Zagorulko Aleksey , Zahorulko Andrii , Budnyk Nina , Shkliaiev Oleksii 
Published: July 2023

The purpose of the study is to determine the structural and mechanical properties of Turkish delight based on the fruit and vegetable paste made from pumpkin, quince and apples, made according to the developed technology. The developed method of production of Turkish delight with fruit and vegetable paste allows to achieve a double effect of the introduction of technology, namely to increase the content of functional ingredients in Turkish delight, as well as to achieve a technological one. Which consists in improved structural and mechanical properties of the locum mass and the finished product, and also allows to achieve original sensory characteristics without the use of dyes and flavorings. The significant content of pectin substances (4.31 % per 100 g) in the fruit and vegetable paste made it possible to achieve a reduction in the recipe content of starch in the technology of Turkish delight. This was confirmed by determining the structural and mechanical properties of the mass and the finished product. Thus, the rational content of starch is set at the level of 80 % of its prescription amount. According to the nature of the curves of the dependence of viscosity on the shear rate and the presence of the ultimate shear stress, locum mass belongs to non-ideally plastic solids. The viscosity index of the locum mass sample with paste and reduced starch content by 20 % has a value similar to the control. Also positive is the shortening of the process of cooking the locum mass in a vacuum-evaporator by 15...20 minutes due to its higher initial dry matter content compared to the control sample. The determination by an expert group of scientists of the indicators of quality in terms of structure and appearance according to a five-point rating showed that the obtained Turkish delight with paste has better indicators. The developed Turkish delight technology can be recommended for healthy nutrition
Engaging the health sector in climate-resilient WASH development
Authors: Marcus Hannah 
Published: July 2023

Abstract
The impact of climate change on water, sanitation, and hygiene (WASH) has driven an increased focus on climate-resilient WASH development. Evidence suggests that adaptation in the WASH sector is underway, but the progress is limited in certain domains and the participation of the public health community may be lacking. Using the Lake Victoria Basin (LVB) as a climate vulnerability setting for this analysis, this study aimed to identify factors that impede full engagement of the health sector in climate-resilient WASH development. In-depth semi-structured interviews were conducted with 13 WASH sector stakeholders across lakeside urban centers in Kenya, Uganda, and Tanzania. Several barriers to health sector engagement were identified including factors related to donor-driven financing and priority setting, a relative neglect of climate vulnerabilities associated with sanitation and hygiene, ministerial siloes, and broader systems of adaptation governance which compromise health sector leadership in climate adaptation. These results suggest room for expansion of interdisciplinary collaborations and deepened involvement of the health sector in WASH-related climate adaptation, which starts with addressing these and other barriers to full health sector engagement.
Percepção dos estudantes dos cursos de ciências sociais aplicadas quanto ao impacto da pandemia Covid-19 durante sua formação
Authors: Broietti Cleber , Valério Heloise Augusto , Michilim Leonardo Montanari , Santos Edom Ferreira dos 
Published: July 2023

Objetivo: Identificar a percepção dos estudantes dos cursos de Ciências Sociais Aplicadas quanto ao impacto da pandemia Covid-19 durante sua formação em universidades do estado Paraná.
Metodologia: A coleta de dados ocorreu por meio de questionário aplicado de maneira online e contou com participação de 115 estudantes de duas universidades paranaenses. O questionário contou com questões abertas e fechadas e estava dividido em seções com informações demográficas, socioeconômicas e percepção do estudante quanto ao impacto da pandemia, para análise das questões fechadas fez-se o uso da estatística descritiva, para as questões abertas utilizou a análise de conteúdo.
Resultados: Quanto ao ensino remoto, aproximadamente 72% dos respondentes relataram dificuldades em se concentrar durante as aulas, 80% dos estudantes pensaram em desistir do curso ao longo da pandemia e cerca de 81% dos respondentes afirmaram que seus estudos foram afetados negativamente pela pandemia, alguns fatores apontados pelos alunos foram o acúmulo de atividades acadêmicas, despreparo desses estudantes para o auto estudo e a falta de ambiente adequado para a aprendizagem.
Contribuições do Estudo: O trabalho contribuiu para a sociedade acadêmica ao identificar a percepção negativa que os estudantes tiveram durante o ensino remoto, também contribui para a literatura dos impactos da pandemia no ensino superior, pois pela percepção dos alunos a pandemia trouxe impactos negativos ao aprendizado em seus respectivos cursos, além disso, o resultado aponta que os alunos de Ciências Sociais Aplicadas, em sua maioria, não dispõe de uma renda familiar muito alta e assim surgiram problemas estruturais para acompanhar as aulas no ensino remoto, nesse sentido, os órgãos públicos precisam se atentar a esse tipo de necessidade e adaptar o ensino as condições desses alunos.
Relationships between the aspects of target costing and business size: a study in the clothing industrial hub of Santa Cruz do Capibaribe-PE
Authors: Sá Célio Beserra de , Callado Antônio André Cunha 
Published: July 2023

Purpose: This article aimed to investigate the relationship between aspects of the target costing process and business size, in the context of companies in the clothing sector in the industrial hub of Santa Cruz do Capibaribe-PE.
Methodology: The study was carried out through an exploratory, descriptive and quantitative research, with the sending of a structured questionnaire to the 110 clothing industries registered in the database of the Federation of Industries of the State of Pernambuco (FIEPE), achieving a rate of response of 21.82%. To analyze the relationships, the Kruskall-Wallis non-parametric statistical test was used, considering a significance level in the order of 95% (p=0.05).
Results: Based on the methodological aspects used, the main results of the research allowed us to conclude that the use of aspects related to the planning phase of the target costing process is influenced by the size of the analyzed companies. On the other hand, the use of aspects of the design phase and the production phase was not influenced by business size.
Contributions of the Study: This study contributes to the specialized literature on management accounting, especially in the Brazilian context, since target costing is still an artifact little explored in national publications. Another contribution to the literature concerns the method used, which permeated a quantitative approach, whereas most research that addresses target costing is developed through case studies. Furthermore, the research also contributes to the analyzed companies, presenting them with a useful management artifact in competitive environments, which can influence their adoption.