bluuebunny/crossref_metadata_2025_split huggingface dataset:
Особенности течения новой коронавирусной инфекции COVID-19 у пациентов с онкогематологическими заболеваниями
Authors: Романенко Николай Александрович , Шилова Е. Р. , Стельмашенко Л. В. , Кайтанджан Е. И. , Кулешова А. В. , Стижак Н. П. , Чеботкевич В. Н. , Сидоркевич С. В. , Грицаев С. В. , Бессмельцев С. С. 
Published: September 2023

Background. The novel coronavirus infection SARS-CoV-2 (COVID-19) is one of high-threat respiratory diseases, characterized by multiple organ disorders with primary respiratory failure and population mortality of 2–5 %. However, the mortality of oncohematological patients treated with chemotherapy is considerably higher.
Aim. To analyze the COVID-19 treatment outcomes in hematological malignancy patients who received drug chemotherapy.
Materials & Methods. The clinical course of COVID-19 was analyzed in 32 hematological malignancy patients aged 31–81 years (median 62 years). The disease onset was the date of the first positive COVID-19 PCR test. These patients were transferred to an infectious hospital specialized in the therapy of the novel coronavirus infection. Pneumonia was confirmed by standard radiography and CT. Blood oxygen saturation, body temperature, ECG, and respiratory rate were monitored. Moderate and severe COVID-19 was observed in 17 (53.1 %) of 32 patients. The condition of 15 (46.9 %) patients was described as good. For comparison, a control group was collected from 32- to 79-year-old (median 63 years) patients (n = 28) having hematological malignancies but no COVID-19.
Results. Nine (28.1 %) of 32 patients under analysis died upon increasing respiratory and multiple organ insufficiency on Day 3–17 (mean 8,6 ± 4,6 days) from the first positive COVID-19 PCR test. Death was predominantly reported in multiple myeloma patients (n = 5) as well as in a patient with Waldenstrom’s macroglobulinemia. In the control group (n = 28) with similar hematological tumors but without COVID-19, three (10.7 %) patients died throughout the 12-month follow-up period. The present paper contains a case report illustrating the clinical features of coronavirus infection in a patient with Waldenstrom’s macroglobulinemia, a monoclonal gammopathy with primary bone marrow lesions.
Conclusion. COVID-19 is a life-threatening viral disease with high mortality in patients with hematological malignancies, especially those with plasma cell dyscrasias.
Хронический гепатит С и онкогематологические заболевания
Authors: Антонова Тамара Васильевна , Ножкин М. С. , Лиознов Д. А. 
Published: September 2023

This review focuses on HCV infection in oncohematological patients. High risk of hepatitis C virus (HCV) infection within this group of patients was proved by a significantly (2.0–2.5 times) higher HCV infection rate in non-Hodgkin’s lymphoma patients compared to population data. Besides, the review demonstrates the importance of HCV in the development and progression of B-cell non-Hodgkin’s lymphomas, which is confirmed by its tumorigenicity. The paper reviews the variant of seronegative (occult) hepatitis С, which is characterized by HCV RNA detected in liver tissue and peripheral blood mononuclear cells by highly sensitive reverse transcription PCR with the absence of serum HCV and HCV RNA antibodies. In this case, patients can present a source of infection. Seronegative hepatitis С is detected in donor blood in 2.2–3.4 % of cases. This infection variant is identified in 20–85 % of oncohematological patients, which needs to be further examined. Comorbid HCV infection is a potential prognostic factor in oncohematological diseases. Oncohematological patients with comorbid chronic hepatitis C (CHC) show considerably worse survival as compared with patients without it. HCV infection is associated with increased complication rates in both chemotherapy and hematopoietic stem cell transplantation (HSCT). Immunochemotherapy, on the other hand, affects CHC exacerbation and progression. High efficacy and good tolerability of direct-acting antiviral agents (DAA) in CHC therapy opened new prospects for their wide use in cases of comorbid diseases. HCV treatment in patients after HSCT still remains an issue. The guidelines for CHC treatment are predominantly formulated with a view to antiviral pre-HSCT therapy which is not always feasible in real-world clinical practice. The review contains examples of effective use of DAA drugs before or after HSCT and a case of antiviral treatment administered simultaneously with HSCT.
Определение соматических мутаций в гене EZH2 и оценка их прогностической значимости при фолликулярной лимфоме 1–3А цитологического типа
Authors: Нестерова Екатерина Сергеевна , Северина Н. А. , Бидерман Б. В. , Судариков А. Б. , Ковригина А. М. , Обухова Т. Н. , Мангасарова Я. К. , Куликов С. М. , Звонков E. E. , Паровичникова Е. Н. , Савченко В. Г. 
Published: September 2023

Aim. To determine the incidence and prognostic value of mutations in exon 16 of EZH2 as well as those of polymorphism с.1582-21А>G (rs2072407) in EZH2 in patients with follicular lymphoma (FL) grades 1–3А in relation to morphologic and cytogenetic tumor characteristics.
Materials & Methods. The prospective cohort study conducted by the National Research Center for Hematology from January 2017 to April 2021 enrolled 80 patients with newly diagnosed FL grades 1/2 and 3А. The median follow-up was 53 months. Molecular and cytogenetic analyses were based on biopsy samples of lymph nodes obtained before chemotherapy. The mutation status of exon 16 in EZH2 and the presence of intronic polymorphism rs2072407 in EZH2 were examined by Sanger sequencing method. Translocation t(14;18)(q32;q21) was detected by karyotyping or FISH.
Results. Mutations in exon 16 of EZH2 (mutEZH2) were identified in 10/80 (13 %) patients. All patients showed missense mutation in codon 646 of EZH2. Translocation t(14;18) was detected in 45/80 (56 %) cases. Poor outcome in the cohort with no t(14;18) was observed 3 times more often than in the group of patients with t(14;18) (p = 0.0001). The presence of t(14;18) was associated with favorable prognosis irrespective of either the mutation status of exon 16 in EZH2 or the FL grade. The analysis of the polymorphism rs2072407 status yielded the following genotypes: AA in 24 % (n = 19), AG in 42 % (n = 34), and GG in 34 % (n = 27) of cases. The variants АА and AG were associated with higher risk of death (hazard ratio 2.9; 95% confidence interval 1.2–10.6; p = 0.01), whereas the genotype GG was associated with wtEZH2 (10 % vs. 37 %) and favorable prognosis (p = 0.065).
Conclusion. Significant biological markers for favorable prognosis in FL appeared to be the presence of t(14;18)(q32;q21) and GG genotype of polymorphism rs2072407 in EZH2. The previously identified prognostic factors (grade 3А, bulky tumor lesions > 6 cm, Ki-67 > 35 %, and a short interval between symptom onset and chemotherapy start) were incorporated into a new unified personalized predictive (index PPI) FL model by supplementing it with two additional biological markers: the presence of t(14;18)(q32;q21) and GG genotype of polymorphism rs2072407. This approach may increase the prognostic value of the new personalized design which will provide the basis for risk-adapted algorithms for FL treatment.
Субпопуляционный состав T-хелперов у больных острыми лейкозами после трансплантации аллогенных гемопоэтических стволовых клеток
Authors: Давыдова Юлия Олеговна , Капранов Н. М. , Никифорова К. А. , Караваева О. С. , Камельских Д. В. , Дроков М. Ю. , Кузьмина Л. А. , Гапонова Т. В. , Гальцева И. В. , Паровичникова Е. Н. 
Published: September 2023

Aim. To identify the characteristics of T-helper subpopulations in healthy donors and to compare them with those reported in acute leukemia patients 6 months after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Materials & Methods. The study enrolled 41 blood donors and 49 patients after-HSCT. The median age of donors was 36 years (range 20–60 years), 29 of them were men and 12 were women. The median age of patients was 37 years (range 19–62 years), 18 of them were men and 31 were women. Acute myeloid leukemia was diagnosed in 27 (55 %) patients and acute lymphoblastic leukemia/lymphoma in 22 (45 %) patients. Myeloablative conditioning was administered to 4 (8 %) patients and reduced intensity conditioning to 45 (92 %) patients. T-helper subpopulations were studied in the blood of healthy donors vs. acute leukemia patients after allo-HSCT. The flow cytometry analysis was conducted to simultaneously assess the expression of markers CD3, CD4, CD8, CD25, CD45RA, CD197, CD28, CCR4, CCR6, CCR10, CXCR3, and CXCR5 in T-cells.
Results. The study demonstrated that the count of T-helpers at different stages of differentiation (regulatory, naive T-cells, memory cells, and effector cells) comprehensively distinguishes healthy donors from patients. Moreover, the functional structure of each of these populations differ in donors vs. patients even on Month +6 after allo-HSCT. Donors appeared to have more polarized cells among the central memory T-helpers. The proportion of T-helpers type 1 among the effector cells was higher is patients.
Conclusion. The results of the study indicate that the Т-cell parameter set can be analyzed to assess immunity and to describe its disorders in different pathologies or after drug chemotherapy.
Flood simulation using the hydrological model and the hydrological–hydrodynamic coupling model in a small watershed in semi-arid and sub-humid region, North China
Authors: Li Jianzhu , Wang Ziqi , Zhang Ting 
Published: September 2023

Abstract

Flood disasters occur frequently in semi-arid and sub-humid mountain watersheds, and their formation mechanism is affected by many factors, resulting in low simulation accuracy. The main purpose of this study is to evaluate the impact of adding actual river channel data on the accuracy of flood simulation. In order to obtain higher-resolution terrain data, an unmanned aerial vehicle (UAV) was used to survey the study area. Taking the Liulin Watershed in Xingtai City, Hebei Province as the research area, the HEC-HMS hydrological model and the HEC-HMS and HEC-RAS coupling model were constructed, respectively, to simulate 26 flood events during the period from 1982 to 2016. The results indicate that the coupled model can reflect the evolution process of river floods. When simulating certain major flood events, the percentage of flood peak error and Nash–Sutcliffe efficiency coefficient (NSE) have improved, such as the NSE of No. 160812 floods increasing from 0.9 to 0.95. However, the simulation accuracy of these two models for small floods in the watershed is relatively low. Future research should focus on how to accurately evaluate the parameter curve number (CN) of the watershed before rainfall and obtain more accurate runoff yield.
Pelatihan kebersyukuran untuk meningkatkan sense of school belonging santri di pondok pesantren
Authors: Prasetyaningrum Susanti , Nurhidayati Nurhidayati 
Published: September 2023

Islamic boarding schools are one of the religius beased-educational facilities where the students must follow much more rules than students in regular school. This makes students feel depressed and bored. That’s finally increase misbehavior in school. These are typical of student’s lack of Sense of School Belonging. The aim of this study was to improve student’s sense of school belonging through gratitude training. This study was conducted using a quasi experiment with non-randomizer method and pre-test-post-test control group design with total of 50 subjects which divided into control group and the experimental group. The results of this study indicate that p <0.05, which means that Ho is rejected (p = 0,000).
Pondok pesantren merupakan salah satu sarana pendidikan berbasis keagamaan dimana para santrinya harus lebih banyak mengikuti peraturan dibandingkan santri di sekolah biasa. Hal ini membuat siswa merasa tertekan dan bosan. Hal itulah yang akhirnya meningkatkan perilaku buruk di sekolah. Hal ini merupakan ciri khas dari kurangnya Sense of School Belonging (rasa memiliki sekolah) pada siswa. Tujuan dari penelitian ini adalah untuk meningkatkan rasa kepemilikan sekolah siswa melalui pelatihan rasa syukur. Penelitian ini dilakukan dengan menggunakan metode quasi eksperimen dengan metode non-randomizer dan pre-test-post-test control group design dengan jumlah subjek 50 orang yang dibagi menjadi kelompok kontrol dan kelompok eksperimen. Hasil penelitian ini menunjukkan p<0,05 yang berarti Ho ditolak (p=0,000).
Clinician Acceptability of a Peripheral Intravenous Passive Safety Catheter with Blood Control: Practical Use Article
Authors: Yeh Jesson , Valencia Diana , Ballek Sue , Curtin Christopher R. , Marshall-Hudson Allyson, , Tuley Michael, , Karpf Angela, 
Published: September 2023

Highlights

Abstract

Aim:
Acceptability, usability, and overall ease of use of a safety engineered peripherally inserted intravenous catheter with blood control septum (PIVCBC) were evaluated among clinicians who frequently use peripherally inserted intravenous catheters (PIVCs). This study was conducted in healthy subjects at a Phase 1 facility.

Methods:
Participating clinicians were ≥18 years of age, employed in a clinical setting, and performed ≥3 PIVC insertions per week. Each clinician completed 6 PIVCBC procedures on 2 to 4 healthy human subjects. Multiple trained observers documented how many attempts it took for the clinician to get a successful stick and what vein was selected for the procedure. Clinicians responded to yes/no questions and to Likert scale statements, describing their experiences with the PIVCBC after the procedures. Video recordings were used to observe procedures. Questionnaire data was summarized by frequency and percent of responses; analyses were conducted using binomial statistics.

Results:
Clinician agreement ranged from 83% to 97% for: able to observe primary and secondary flashbacks, able to use their regular PIVC insertion technique, found the catheter easy to insert, able to easily remove the needle from the catheter hub, believed the catheter would protect them from blood exposure during insertion, and able to flush the catheter. Overall, 96.7% of the clinicians found the PIVCBC to be acceptable.

Conclusions:
Overall, the PIVCBC was acceptable, easy to use, and allowed clinicians to maintain their usual PIVC insertion technique while they felt protected from blood exposure during insertion of the catheter.
Utviklingen av USAs militære tilstedeværelse på NATOs østre flanke – beroligelse av allierte, avskrekking av Russland og eskaleringskontroll
Authors: Jakobsen Eskil 
Published: September 2023

I takt med økende russisk revansjisme og aggresjon fra 2014 har USAs tilnærming til militær tilstedeværelse på NATOs østre flanke gjennomgått en endring. Overordnet kan utviklingen oppfattes som endring i rasjonale fra beroligelse av allierte til avskrekking av Russland gjennom straff og de seneste år avskrekking gjennom nektelse. Dette har resultert i endrede strukturer for tilstedeværelse, med påfølgende endring i disposisjoner på bakken som har bidratt til å øke troverdigheten til NATOs avskrekkingsdoktrine. Den retoriske offensiviteten i den amerikanske strategiske kommunikasjonen har også blitt mer kraftfull og øvingsaktiviteten oppskalert. Dette indikerer endring i amerikansk oppfatning av hva som oppfattes som eskalerende virksomhet. Det foreligger tverrpolitisk enighet om videreføring av amerikansk deep-engagement i Europa, som også kan spores i det amerikanske militærvesenet. Dette underbygger teorien om en «institusjonalisert praksis» for militær tilstedeværelse og stormaktsbestandighet. Den økte troverdigheten til USAs og NATOs avskrekking på den østre flanken senker sannsynligheten for fait accompli-scenarioer. Dette har sikkerhetspolitiske implikasjoner for land lokalisert andre steder som Russland kan ønske å utfordre, både konvensjonelt og med sammensatte virkemidler.
Abstract in English:The Evolution of US Military Presence on NATO’s Eastern Flank: Reassuring Allies, Deterring Russia, and Managing EscalationConcurrent with increasing Russian revanchism and aggression from 2014, the US approach to military presence on NATO’s Eastern flank has evolved. Overall, the development could be perceived as change in rationale from reassurance of allies to deterrence of Russia by punishment and, in recent years, deterrence by denial. This has resulted in altered structures for presence, resulting in changes of dispositions on the ground that has contributed to increasing the credibility of NATO’s deterrence doctrine. The rhetorical offensiveness of U.S. strategic communication has also become more powerful and exercise activity scaled up. This indicates a change in US perception of escalating activity. There is persistent bipartisan agreement on the continuation of US deep-engagement in Europe, with similar perceptions in the US military-leadership. This underpins the theory of an “institutionalized practice” of military presence and Great Power Persistence. The enhanced credibility of US-NATO deterrence on the Eastern flank lowers the likelihood of fait accompli-scenarios. This has security implications for countries located elsewhere that Russia may wish to challenge, both conventionally and through Hybrid means.
Training and development of employees — a steady trend in the management of human resources in the system of social and labor relations
Authors: Ananchenkova P. I. 
Published: September 2023

Modern social and labor relations necessitate the formation of sustainable and effective systems of training and development of employees initiated by top managers and owners of companies. In the conditions of digital transformations and rapid change of technological approaches to the production process, the problem of reproduction of professional skills most in demand by employers is being actualized.The paper presents data reflecting the position of specialists of analytical and consulting agencies (such as Delloit, BCG, ManpowerGroup, etc.), which identify the following main trends in training and development that determine approaches to the organization and implementation of employee training and development programs: organizational flexibility and continuous training; professional development and retraining for the future; the use of training experience focused on the personal needs of employees; wider use of training platforms — LXP for the purpose of individualization of training; introduction of artificial intelligence (AI) technologies in the workplace.It is concluded that in order to maintain competitiveness, organizations must adapt their employee training and development strategies in a timely manner to the conditions of rapidly changing social reality and trends in human resource management.
The Role of Decentralized Electrode Boiler in Ancillary Services and District Heating: a Feasibility Assessment
Authors: Gicevskis K. , Linkevics O. 
Published: September 2023

Abstract
This article evaluates the feasibility of using electrode boiler in grid ancillary services and district heating scenarios. Electrode boilers in the context of electricity grid management can be considered as a relatively new technology. This study assesses the technical and economic viability of electrode boiler by considering various factors such as energy demand, technical feasibility, economic viability, and regulatory market conditions. The simplified mathematical model has been developed for simulation of electrode boiler use for grid services and heat production. The results have shown that electrode boiler have the potential to be a cost-effective solution for heating and grid balancing services in certain scenarios. However, it may not be applicable or economically viable in all situations or regions; thus, further research and development is needed to fully realize their potential.
Surgical outcome and prognostic factors for 39 recurrent spinal hydatid cysts
Authors: Obame Fresnel Lutèce Ontsi , Dokponou Yao Christian Hugues , Mohcine Salami , Elmi Saad Moussa , Imbunhe Napoleao , El Kacemi Inas , Mouhssani Mohamed , Sahri Imad-Eddine , Abderrahmane Housni , Laaguili Jawad , El Asri Abad Chérif , Gazzaz Miloudi 
Published: September 2023

Background:
Cystic bone echinococcosis accounts for 0.5–4% of all reported cases, and 45% occur in the spine. Our aim was to review the clinical and radiological features, surgery, and outcomes for 39 patients with recurrent spinal hydatidosis.

Methods:
Thirty-nine reports of patients with recurrent spinal hydatidosis (2011–2020) were followed for an average of 9.28 ± 5.60 months.

Results:
Lesions occurred in descending order in the; lumbar (48.7%), thoracic (43.6%), and cervical spine (7.7%). Total cyst resection was achieved in 28 of 39 patients (71.8%). Intraoperative cyst rupture occurred in 13 patients (33.3%). The postoperative American Spinal Injury Association (ASIA) score was “good” in 82% of patients. Those with “poor” postoperative ASIA scores had a 41% incidence of recurrent thoracic hydatid cysts; further, they demonstrated significantly higher recurrence rates if cysts had ruptured intraoperatively (P = 0.001). In addition, laminectomy, subtotal original cyst resection (P < 0.007), and a thoracic location were all significantly associated with higher recurrence rates (P < 0.04).

Conclusion:
The majority of patients demonstrated improvement following surgery for cervical hydatid cysts. Notably, those with poor outcomes typically experienced intraoperative ruptures of their thoracic hydatid cysts, contributing to high cyst recurrence rates.
Observation on the effect of interventional devascularization in the treatment of liver cirrhosis with portal hypertension
Authors: Bo Chen  , Donghong Shi  , Min Ai  , Longjiang Zhang  
Published: September 2023

Abstract: Objective: To analyze the clinical effect of interventional devascularization in the treatment of liver cirrhosis with portal hypertension. Methods: 80 patients with liver cirrhosis and portal hypertension admitted between January 2020 and January 2023 were selected as research subjects. They were divided into a control group (surgical devascularization) and an experimental group (interventional devascularization) through the computer grouping method, and the effect of the treatment received by both groups were compared. Results: (i) The efficacy of the treatment received in the experimental group was 94.87%, which was significantly higher than that of the control group, which was 76.92% (P < 0.05). (ii) There was no difference in the levels of alanine transaminase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) between the control group and the experimental group before treatment (P > 0.05); after treatment, the levels of ALT, AST, and ALP in the experimental group were statistically significantly lower than those in the control group (P < 0.05). (iii) Compared with the total complication rate of 28.21% in the control group, the total complication rate of the experimental group was lower at 10.25%, and the statistical significance was established (P < 0.05). Conclusion: Interventional devascularization has demonstrated positive outcomes in treating liver cirrhosis and portal hypertension. This is evident in the enhancement of liver function and its high safety profile. Consequently, it merits wider adoption and utilization in clinical practice.