bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatially Resolved Organic Whispering‐Gallery‐Mode Hetero‐Microrings for High‐Security Photonic Barcodes
Authors: Feng Xingwei , Lin Ru , Yang Shuo , Xu Yuyu , Zhang Tongjin , Chen Shunwei , Ji Yingke , Wang Zifei , Chen Shiwei , Zhu Chaofeng , Gao Zhenhua , Zhao Yong Sheng 
Published: August 2023

AbstractWhispering‐gallery‐mode (WGM) microcavities featuring distinguishable sharp peaks in a broadband exhibit enormous advantages in the field of miniaturized photonic barcodes. However, such kind of barcodes developed hitherto are primarily based on microcavities wherein multiple gain medias were blended into a single matrix, thus resulting in the limited and indistinguishable coding elements. Here, a surface tension assisted heterogeneous assembly strategy is proposed to construct the spatially resolved WGM hetero‐microrings with multiple spatial colors along its circular direction. Through precisely regulating the charge‐transfer (CT) strength, full‐color microrings covering the entire visible range were effectively acquired, which exhibit a series of sharp and recognizable peaks and allow for the effective construction of high‐quality photonic barcodes. Notably, the spatially resolved WGM hetero‐microrings with multiple coding elements were finally acquired through heterogeneous nucleation and growth controlled by the directional diffusion between the hetero‐emulsion droplets, thus remarkably promoting the security strength and coding capacity of the barcodes. The results would be useful to fabricate new types of organic hierarchical hybrid WGM heterostructures for optical information recording and security labels.
Nano‐sized Co(II), Ni(II), and Zr(IV) complexes of quinaldine‐based azo dye for promising therapeutic and catalytic applications: Synthesis, characterization, density functional theory studies and molecular docking
Authors: Khedr Abdalla M. , Gaber Mohamed , Elsharkawy Mohsen , Bakr Eman A. , Atlam Faten M. 
Published: August 2023

Novel azo dye containing the heterocyclic quinaldine nucleus, 3‐((2‐methylquinolin‐4‐yl)diazenyl)naphthalen‐2‐ol HL, and its Co(II), Ni(II) and Zr(IV) nano‐sized metal chelates have been synthesized and fully characterized by alternative analytical and spectral techniques. The finding indicated that the ligand coordinated as a monobasic bidentate via azo nitrogen and hydroxyl oxygen atom, resulting in octahedral geometry towards Co(II) and Zr(IV) complexes, and square planer geometry towards Ni(II) metal ion. Theoretical studies by DFT/B3LYP/6‐311+G(d,p)/LANLDZ including energetic parameters, geometrical optimization, dipole moment, and HOMO–LUMO energy gap were applied to support the geometrical arrangement of the complexes. The produced complexes were generated at the nanoscale, as evidenced by the average particle size from TEM. The average particle size calculated from TEM images for Co(II), Ni(II), and Zr(IV) complexes is 6.0, 12.0, and 5.5 nm, respectively. The antibacterial activity of the ligand compared with its metal complexes shows enhanced activity over the metal complexes against different types of bacteria. Antitumor efficacy of the compounds was tested against A‐549 and PANC‐1 cells, compared with the vinblastine standard. The cytotoxic efficiency of both Co(II) and Ni(II) complexes exceeded that of vinblastine. The anticancer activity of the Zr complex was then studied using molecular docking to determine the interactions between this molecule and PANC‐1. Docking studies revealed that the Zr complex produces four hydrogen bond contacts with the active amino acid residues Arg 136 and Asp 140, two hydrophobic interactions with Val 50 and Leu 147, and two electrostatic interactions with Arg 136. Also, the catalytic property of the free ligand and nanocomplexes were tested on the oxidative degradation of methyl violet 2B dye in the presence of H2O2. The following arrangement was observed for the pseudo‐first‐order rate constants: Co(II) complex (0.068 min−1) > Ni(II) complex (0.066 min−1) > Zr(IV) complex (0.061 min−1) > HL (0.037 min−1).
N‐alkylation of benzamides/sulfonamides using alcohols via borrowing hydrogen approach by well‐defined Pd (II) pincer complexes
Authors: Anandaraj Pennamuthiriyan , Ramesh Rengan 
Published: August 2023

The development of green, sustainable, and atom‐economical procedure for the construction of amides via C‐N bond formation is a high priority in synthetic organic community. In this research article, we demonstrate a simple and an efficient catalytic protocol for N‐alkylation of benzamides/sulfonamides using aromatic primary alcohols as coupling partners through borrowing hydrogen (BH) strategy by employing newly constructed palladium (II) O^N^O pincer complexes. All the palladium complexes are characterized by analytical and spectral methods (FT‐IR, NMR, and HRMS). Further, the solid‐state molecular structures of the complexes have been well authenticated by single‐crystal XRD studies. The present N‐alkylation protocol is facile, worked in low catalyst loading (0.5 mol%), and furnishes the desired N‐alkyl amides with excellent yields up to 92%. In this methodology, the reaction proceeds via the formation of intermediates such as aldehyde and (E)‐N‐benzylidenebenzamide with a release of water as ecological by‐product. The control experiments and plausible mechanistic investigations suggested that the coupling reaction was initially proceeds via dehydrogenation of alcohol and generate the alkylated products through hydrogen auto‐transfer. A large‐scale synthesis of N‐(4‐methoxybenzyl)benzamide proves the effectiveness of the Pd (II) pincer catalysts.
Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts
Authors: Silva Lucas Santos , de Melo Maryanne Trafani , Sponchiado Pedro Augusto Invernizzi , Júnior Fernando Barbosa , Tapia‐Blácido Delia Rita , Ciancaglini Pietro , Ramos Ana Paula , Maniglia Bianca Chieregato 
Published: August 2023

AbstractBone defects and injuries are challenging issues in regenerative medicine. Guided bone regeneration (GBR) techniques use biomaterials as scaffolds to support the healing of damaged bone tissue. In this context, there is growing interest in developing new biomaterials with bioabsorbable and bioactive properties to increase GBR effectiveness. In this study, composite corn starch/hydroxyapatite nanoparticle (HAp) biomembranes were synthesized to achieve bioresorbable and bioactive properties compatible with applications in GBR. Starch is a renewable source and presents suitable rheological properties for membrane preparation; in turn, HAp is well known for its osteogenic properties. The biomembranes were prepared by solvent casting (5 wt% aqueous corn starch suspension containing different amounts of HAp (i.e., 0, 2, 5, and 10% of the corn starch weight), to give the membranes HAp_0%, HAp_2%, HAp_5%, and HAp_10%, respectively). The physicochemical and biological properties of the biomembranes were assessed. The concentrations of up to 10% of HAp were homogeneously dispersed in the composite biomembranes. HAp addition increased the biodegradability and the ability of the biomembranes to release Ca2+. The biomembranes containing HAp were more mechanically resistant and less flexible and were not toxic to osteoblasts. Moreover, compared to pure corn starch biomembranes, osteoblasts adhered better to the composite biomembranes. The higher the HAp content, the greater the mineralization promoted by osteoblasts on the composite biomembranes. HAp addition also resulted in composite biomembranes with better fracture healing efficiency in vitro. Therefore, composite corn starch/HAp biomembranes have excellent characteristics, including biodegradability, bioactivity, mechanical strength, and biocompatibility, for the development of new materials aimed at GBR.
Flame retardancy and mechanical properties of epoxy resin with the phytic acid‐derived flame retardant
Authors: Wang Song , Meng Lingchen , Chen Qi , Li Sanxi , Zhang Ailing 
Published: August 2023

AbstractThe synthesis and application of the bio‐derived flame retardant can meet the current requirements for the high‐efficient and sustainable development of flame retardants. Therefore, using phytic acid (PA), 9,10‐dihydro‐9‐oxa‐10‐phosphaphenanthrene‐10‐oxide (DOPO), and piperazine as raw materials, a PA‐derived flame retardant (PAPDOPO) was prepared. Fourier transform infrared spectroscopy and x‐ray diffraction techniques were applied to characterize the structure of the PAPDOPO. In the prepared flame‐retardant epoxy resin (FEP), PAPDOPO showed high flame retardancy. When 4% PAPDOPO was added into epoxy resin (EP), the prepared FEP (EP‐PAPD‐4) passed the V‐0 level in the UL‐94 test, and the limited oxygen index value of EP‐PAPD‐4 reached 35.3%. Microcombustion calorimetry test was also applied to demonstrate the performance of PAPDOPO. The peak heat release rate of EP‐PAPD‐4 was reduced by 30.4% compared with that of the pure EP. Due to the low addition amount of PAPDOPO in FEP, the mechanical properties of the FEP using PAPDOPO as flame retardant were hardly decreased compared with pure EP.
Movement, ranging patterns and habitat use of Indo‐Pacific humpback dolphins (Sousa chinensis) in the Langkawi Archipelago and adjacent Perlis‐Kedah coastal waters, Malaysia
Authors: Teoh Zhi Yi , Then Amy Yee‐Hui , Ng Jol Ern , Kuit Sui Hyang , Jamal Hisne Fairul Izmal , Ponnampalam Louisa Shobhini 
Published: August 2023

Abstract1. Studies on the ranging patterns and habitat use of Indo‐Pacific humpback dolphins (Sousa chinensis) in Southeast Asia are scarce but essential to inform conservation and management of a species known to be susceptible to anthropogenic pressures.2. This study is the first to investigate the long‐term movement, range sizes and habitat use of humpback dolphins in the Langkawi Archipelago and adjacent Perlis‐Kedah mainland coast of Malaysia using boat‐based photo‐identification surveys conducted between 2010 and 2020.3. A total of 669 humpback dolphin individuals were identified, making it one of the largest photo‐ID catalogues within their geographic range. Lagged identification rates suggested that some individuals maintained long‐term site fidelity in the study area.4. Low transition probabilities and 194 photo‐identification matches revealed humpback dolphins moved minimally between Langkawi and the adjacent Perlis‐Kedah mainland; however, most southward dolphin movements did not extend beyond Kuala Jerlun in northern Kedah.5. The mean range sizes estimated for 16 regularly sighted individuals through minimum convex polygon and kernel density estimate 95% utilization distribution were significantly different, at 338.2 ± 183.8 and 75.6 ± 28.6 km2, respectively.6. Most individual and population core areas (i.e. kernel density estimate 50% utilization distribution) overlapped with core feeding and nursery grounds in shallow coastal and estuarine waters (i.e. <10 m deep and <1.3 km from the coastline).7. Dolphin range size and spatial use patterns were probably linked to prey distribution and availability (i.e. influenced by environmental factors such as habitat features) and social groupings and dynamics.8. These findings inform science‐based recommendations for habitat management, including implementing restricted areas from coastal development, vessel speed‐limit zones and boating codes‐of‐conduct, to minimize anthropogenic impacts and support sustainable coastal development in the binational Satun‐Langkawi Important Marine Mammal Area.
Sentence memory recall in adolescents: Effects of motor enactment, keyboarding, and handwriting during encoding
Authors: Söderlund Göran B. W. , Torvanger Silje , Hadjikhani Nouchine , Johnels Jakob Åsberg 
Published: August 2023

AbstractBackgroundPrior research has shown that memory for action sentences is stronger when stimuli are enacted during encoding than simply listened to: the so‐called enactment effect. The goal of the present study was to explore how writing during encoding—through handwriting and through keyboarding—fares compared with enacting, in supporting memory recall.MethodsOne hundred Norwegian high school students (64 girls, 36 boys) aged 16–21 years (M = 17.1) participated in the study. Four lists of verb–noun sentences with 12 sentences in each list were presented in four encoding conditions: (i) motor enactment, (ii) verbal listening, (iii) handwriting, and (iv) keyboarding.ResultsResults revealed a significant main effect of encoding condition, with the best memory gained in the enactment condition. Regarding writing, results showed that handwriting and keyboarding during encoding produced the lowest recall in comparison with the enactment and verbal listening conditions.ConclusionThese results thus provide additional support for the enactment effect. While there has been much discussion on the relative benefits of handwriting versus keyboarding on student performance, both seemed to be equally poor strategies for the particular learning task explored here, potentially through increased cognitive load.
Perspectives on the development of highly active, stable, and cost‐effective OER electrocatalysts in acid
Authors: Yoon Hyunseok , Ju Bobae , Kim Dong‐Wan 
Published: August 2023

AbstractPolymer electrolyte membrane water electrolysis (PEMWE) is an attractive hydrogen energy production technology that offers various advantages such as compact design, high operating pressure, high current densities, and high hydrogen gas purity. However, PEMWE still faces several critical challenges, particularly with respect to the oxygen evolution reaction (OER) at the anode. Highly active, corrosion‐resistant electrocatalytic materials are required for the acidic OER owing to its sluggish kinetics involving four‐electron transfer under harsh anodic potentials. To date, IrO2‐ or RuO2‐based noble metal electrocatalysts have been employed as commercial acidic OER electrocatalysts for PEMWE. However, they remain inadequate in terms of satisfying the industrial activity/stability‐related requirements. Above all, the two noble metals are too rare and expensive, which significantly inhibits widespread commercialization of PEMWE. Therefore, low‐cost, highly active, and highly stable OER electrocatalysts that can operate in acidic media must be urgently developed. This review paper presents various state‐of‐the‐art strategies employed to address the aforementioned issues by classifying them according to objectives such as improving activity, enhancing stability, and reducing cost. Then, finally, we summarize major tasks and strategies to overcome them and put forward a few issues in this field.
Optimization of ionizable lipids for aerosolizable mRNA lipid nanoparticles
Authors: Lewis Mae M. , Soto Melissa R. , Maier Esther Y. , Wulfe Steven D. , Bakheet Sandy , Obregon Hannah , Ghosh Debadyuti 
Published: August 2023

AbstractAlthough mRNA lipid nanoparticles (LNPs) are highly effective as vaccines, their efficacy for pulmonary delivery has not yet fully been established. A major barrier to this therapeutic goal is their instability during aerosolization for local delivery. This imparts a shear force that degrades the mRNA cargo and therefore reduces cell transfection. In addition to remaining stable upon aerosolization, mRNA LNPs must also possess the aerodynamic properties to achieve deposition in clinically relevant areas of the lungs. We addressed these challenges by formulating mRNA LNPs with SM‐102, the clinically approved ionizable lipid in the Spikevax COVID‐19 vaccine. Our lead candidate, B‐1, had the highest mRNA expression in both a physiologically relevant air–liquid interface (ALI) human lung cell model and in healthy mice lungs upon aerosolization. Further, B‐1 showed selective transfection in vivo of lung epithelial cells compared to immune cells and endothelial cells. These results show that the formulation can target therapeutically relevant cells in pulmonary diseases such as cystic fibrosis. Morphological studies of B‐1 revealed differences in the surface structure compared to LNPs with lower transfection efficiency. Importantly, the formulation maintained critical aerodynamic properties in simulated human airways upon next generation impaction. Finally, structure–function analysis of SM‐102 revealed that small changes in the number of carbons can improve upon mRNA delivery in ALI human lung cells. Overall, our study expands the application of SM‐102 and its analogs to aerosolized pulmonary delivery and identifies a potent lead candidate for future therapeutically active mRNA therapies.
Integration of metabolomics and machine learning revealed tryptophan metabolites are sensitive biomarkers of pemetrexed efficacy in non‐small cell lung cancer
Authors: Sun Runbin , Fei Fei , Wang Min , Jiang Junyi , Yang Guangyu , Yang Na , Jin Dandan , Xu Zhi , Cao Bei , Li Juan 
Published: August 2023

AbstractBackgroundAnti‐folate drug pemetrexed is a vital chemotherapy medication for non‐small cell lung cancer (NSCLC). Its response varies widely and often develops resistance to the treatment. Therefore, it is urgent to identify biomarkers and establish models for drug efficacy evaluation and prediction for rational drug use.MethodsA total of 360 subjects were screened and 323 subjects were recruited. Using metabolomics in combination with machine learning methods, we are trying to select potential biomarkers to diagnose NSCLC and evaluate the efficacy of pemetrexed in treating NSCLC. Furtherly, we measured the concentration of eight metabolites in the tryptophan metabolism pathway in the validation set containing 201 subjects using a targeted metabolomics method with UPLC‐MS/MS.ResultsIn the discovery set containing 122 subjects, the metabolic profile of healthy controls (H), newly diagnosed NSCLC patients (ND), patients who responded well to pemetrexed treatment (S) and pemetrexed‐resistant patients (R) differed significantly on the PLS‐DA scores plot. Pathway analysis showed that glycine, serine and threonine metabolism occurred in every two group comparisons. TCA cycle, pyruvate metabolism and glycerolipid metabolism are the most significantly changed pathways between ND and H group, pyruvate metabolism was the most altered pathway between S and ND group, and tryptophan metabolism was the most changed pathway between S and R group. We found Random forest method had the maximum area under the curve (AUC) and can be easily interpreted. The AUC is 0.981 for diagnosing patients with NSCLC and 0.954 for evaluating pemetrexed efficiency.ConclusionWe compared eight mathematical models to evaluate pemetrexed efficiency for treating NSCLC. The Random forest model established with metabolic markers tryptophan, kynurenine and xanthurenic acidcan accurately diagnose NSCLC and evaluate the response of pemetrexed.
Sustainable return to work among breast cancer survivors
Authors: Ruiz de Azua Garazi , Kousignian Isabelle , Vaz‐Luis Ines , Di Meglio Antonio , Caumette Elsa , Havas Julie , Martin Elise , Martin Anne‐Laure , Querel Ophelie , Vanlemmens Laurence , Pistilli Barbara , Coutant Charles , Cottu Paul Henri , Merimeche Asma Dhaini , Lerebours Florence , Tredan Olivier , Jouannaud Christelle , Levy Christelle , Dumas Agnes , Menvielle Gwenn 
Published: August 2023

AbstractPurposeThis study assessed sustainable return to work (SRTW) of breast cancer survivors (BCS).MethodsWe used data from the prospective French cohort, CANTO. We included 1811 stage I–III BCS who were <57 years old and employed at the moment of diagnosis and working 2 years after diagnosis. Using logistic regression, we investigated the role of clinical, health and socio‐economic factors, and the work environment on SRTW 3 years after diagnosis. We compared having any sick leave with having worked continuously and being unemployed to having worked continuously between 2 and 3 years after diagnosis.ResultsOverall, 77% (n = 1395) worked continuously after return to work (RTW). Out of the other 416 BCS, 66% had any sick leave period, 33% had been unemployed, 4% had an early retirement, 2% a disability and 1% another status (multiple situations possible). Being on sick leave was associated with age > 50 (OR = 0.59; 95%CI = 0.43–0.82), stage III (2.56; 1.70–3.85), tumour subtype HR+/HER2+ (0.61; 0.39–0.95), severe fatigue (1.45; 1.06–1.98), workplace accommodations (1.63; 1.14–2.33) and life priorities (0.71; 0.53–0.95). Unemployment was associated with age > 50 (0.45; 0.29–0.72), working in the public sector (0.31; 0.19–0.51), for a small company (3.00; 1.74–5.20) and having a fixed‐term contract (7.50; 4.74–11.86).ConclusionsA high number of BCS have periods of sick leave or unemployment after RTW. The determinants differ between sick leave and unemployment.Implications for cancer survivorsBCS need to be supported even after RTW, which should be regarded as a process.
Immune checkpoint‐related gene polymorphisms are associated with acute myeloid leukemia
Authors: Wu Yuyan , Li Mingying , Meng Guangqiang , Ma Yuechan , Ye Jingjing , Sun Tao , Ji Chunyan 
Published: August 2023

AbstractBackgroundChemotherapy is still the standard regimen for treating acute myeloid leukemia (AML) and its disappointing efficacy requires the urgent need for new therapeutic targets. It is well known that immune response plays an increasingly significant role in the pathogenesis of AML.MethodsWe detected nine single nucleotide polymorphisms (SNPs) in immune checkpoint‐related genes, including PD1, LAG3, TIM3, and TIGIT in 285 AML inpatients and 324 healthy controls. SNP genotyping was performed on the MassARRAY platform. Furthermore, we analyzed the relationship between the susceptibility and prognosis of AML and the selected SNPs.ResultsOur results showed that rs2227982 and rs10204525 in PD1 were significantly associated with susceptibility to AML after false discovery rate correction. PD1 rs10204525 also showed a significant correlation with the response to chemotherapy and risk stratification of AML. Importantly, the AA genotype of PD1 (rs2227982) under the recessive model showed a negative impact on AML prognosis independently.ConclusionsOur results indicate that PD1 SNPs are important for susceptibility and prognosis in AML, which may provide a new therapeutic target for AML patients.
Progress and Insights on Graphene and MXene‐based Emerging 2‐Dimensional Conductive Nanomaterials for Fabrication of Flexible Gas Sensors
Authors: Wang Fei , Yeap Swee Pin , Cheok Choon Yoong , Ang Chun Kit , Saidur Rahman 
Published: August 2023

AbstractOwing to the unique properties such as pristine interfaces, ultra‐thin and uniform thickness, 2D nanomaterials have attracted the attention from many researchers. Particularly, rGO and MXene 2D nanomaterials have received intense research interest in the application of gas sensors due to their high electrical conductivity. The coating of these 2D nanomaterials onto plastic, paper or textile substrate formed flexible, stretchable and portable gas sensors as an alternative to the conventional rigid gas sensors. To date, numerous research works on flexible gas sensors using either graphene or MXene have been published. However, the reported data is scattered and varied by multiple factors. In this short review, we revisit the advances in the current application of 2D conductive nanomaterials (mainly rGO and MXene) and their nanocomposites with metal oxides on flexible gas sensors. We focus on recent developments regarding the working mechanism, advantages, disadvantages, and performances (including gas response, selectivity, response time, and recovery time) of each type of gas sensor. Finally, this short review sheds light on future directions and prospects in the field of flexible gas sensors using 2D nanomaterials.