bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudo de impacto de vizinhança e as implicações prejudiciais aos munícipes brasileiros geradas pelo ruído
Authors: Strino Claudio Luiz , Bezerra Marcelo Roberto Ventura Dias de Mattos 
Published: May 2023

A instalação de um empreendimento em um local implica em riscos específicos, sendo por tanto necessário à identificação desses riscos no espaço urbano onde se pretende construir o empreendimento, não esquecendo que durante a construção poderá agregar riscos aos já existentes antes das obras de instalação, assim como geração de tráfego e aumento dos níveis ruído por consequência. Os impactos mais comuns nas instalações de novos empreendimentos estão relacionados à demanda por todos os bens públicos ou privados de utilidade pública destinado à prestação de serviços necessários ao funcionamento das cidades, implantados mediante autorização do poder público em espaços públicos e privados, além da poluição e degradação ambiental, aumento do tráfego, dificuldade da fluidez na cidade e impacto sonoro com incomodo aos munícipes. A implantação do Estudo de Impacto de Vizinhança no Brasil torna-se de fundamental importância por se tratar de um instrumento legal e normativo para o uso do solo urbano, implantado no país ocorrido em 2001, com a promulgação da Lei 10.257, denominado Estatuto da Cidade. A importância específica do Estudo de Impacto de Vizinhança quanto ao tratamento do impacto sonoro na instalação de novos empreendimentos, está destacada e dirigida desde a fase de implantação, sendo necessário um levantamento através de avaliações dos níveis de ruído a fim de conhecer as vulnerabilidades da região onde o estabelecimento será implantado, bem como posteriormente ser periodicamente avaliado para estabelecer medidas de controle das emissões sonoras.
Technology Readiness Index in Adopting the COVID-19 Reporting System at Referral Hospitals in Semarang City, Indonesia
Authors: Ernawati Dyah , Kurniadi Arif , Said Abu , Anjani Sylvia , Isworo Slamet 
Published: May 2023

Background and Objective: As a referral health care facility, the hospital has prepared an Allrecord COVID-19 reporting system, which has been integrated with the Hospital Management Information System. To explain optimism and innovation perceptions. users' perceptions of comfort and security in the covid-19 reporting system application.
Methods: The Mix-Method method was used in this study, with research subjects being Covid-19 data reporting officers at the Semarang COVID-19 referral hospital types C and B. The instrument employed a questionnaire with four dimensions (optimism, innovation, discomfort, and insecurity). Results: The perceived optimism obtained with a score of more than 3 is 86%, and with a score of less than 3 is 14%, indicating that this is consistent with the user's perception of optimism when using the Covid-19 reporting system application. The perception of innovation obtained is greater than a score of three, indicating a balance between agreeing and disagreeing with the perception of innovation from users of the COVID-19 reporting system application. The value of the user's perception of discomfort is greater than 3, with a score of 30%, and less than 3, with a score of 70%, indicating that they disagree with the user's perception of discomfort when using the co-19 reporting system application. Meanwhile, a perceived insecurity score greater than 3 is 0%, and a score less than 3 is 100%, indicating that it disagrees with the user's perception of insecurity when using the covid-19 reporting system application.
Conclusion: The application for the COVID-19 reporting system is satisfactory, and users are eager to begin using it. Continuous socialization of the use of reporting systems is required in referral hospitals.
The Effect of Vitamin E Supplement on Creatine Kinase MB, C-Reactive Protein, Creatinine and Urea Levels of Albino Rats Fed with High Fat Diet
Authors: Anthony Waribo, Helen , Kenneth Nkwazema, Amobi , Ngowari Aleruchi-Didia, Tarila , Ngozi Brisibe, 
Published: May 2023

Aim: This study was designed to assess the effect of vitamin E supplement on Creatine Kinase (CK-MB) C - reactive protein, (C-RP), urea and creatinine of albino rats fed with high fat diet.
Methodology: A total of twenty (20) albino rats of both sexes were used in this study. They were grouped into four (4) groups comprising of five (5) rats each. Group 1 was fed with normal diet; group 2 with normal diet and treated with vitamin E supplement (70 mg/kg); group 3 was fed with high fat diet only, while group 4 was fed with high fat diet and treated with vitamin E supplement (70 mg/kg). The treatments were administered daily using oral gavage method for a period 21 days. After the experimental period, the animals were sacrificed and blood samples collected for the analysis of CK-MB, CRP, urea and creatinine respectively using ELISA and colorimetric method with a spectrophotometer. Data generated were analyzed statistically using SPSS version 20 and P = 0.05 was considered statistically significant.
Results: The results revealed a significance difference in C-RP (mg/l) levels (P < 0.001) amongst the groups with a decreased C-RP levels in group 2 (1.43 ± 0.39) compared to group 1 (1.94 ± 0.53), then in group 4 (2.27 ± 0.53) which is also decreased compared to group 3 (3.31 ± 0.63). For CK-MB there was also a significant difference among the different groups. In group 2, it was 1.94 ± 0.65 ng/ml which was decreased compared to group 1 (2.22 ± 0.55), and group 4 (2.74 ± 0.68) compared to group 3 (3.31 ± 0.62). For the urea and creatinine results, there was no significant difference (p > 0.05) among the groups when the mean levels were compared.
Conclusion: This shows that administration of vitamin E to rats fed normal or high fat diet could significantly reduce the plasma levels of CRP and CK-MB hence having some ameliorative effects on high fat induced inflammatory and cardiovascular risks or conditions.
C-reactive Protein and Immunological Indices of Lectin Extract from Edible Fungus (Pleurotus tuber-regium) on Wounded Rats
Authors: Ejike Igbokwe Gabriel , Christian Ezeigwe Obiajulu , Godwin Nwobodo Valentine Osita 
Published: May 2023

Lectins are proteins/glycoproteins of non-immune origin with wide distribution in nature with the ability to agglutinate erythrocytes and recognize glycoconjugates. The study aimed at determining the healing effect of lectin extract from Pleurotus tuber- regium on acute wounds induced in male albino rats. Ten grams of the powdered edible mushroom of Pleurotus tuber-regium were used to extract lectin via the dialysis method. A total of 45 albino rats randomized into 9 groups of 5 rats each into Category A and B groups, and the blood sample was collected by ocular puncture for the category A after 10 days, while cardiac puncture for the Category B group after 28 days. The collected blood sample was analyzed for the various immunological parameters, using the quantitative ELISA technique for C-reactive protein, and Mindray BC-200 machine for full blood count. At negative control, the WBC levels and the neutrophils were increased for the Category B group to 19.79±1.22/L and 3.26±0.25%. A 2mg/kg lectin oral administration had 4.72±0.14% neutrophils for Category A group, while Category B group topical application, the highest value at 8mg/kg lectin had 4.98±0.52%. Both 36 mg/kg amoxicillin application and oral administration of lectin generated factors as C3b, and Histamine (H1and H2) receptors on eosinophils by chemotaxis attraction. With Category B group, 8 mg/kg lectin topical had the highest value of 21.30±2.17% eosinophils, and the difference in Category B group compared to the normal control at 17.64±1.1 81% was significant p≤ 0.05 and the rats would be showing signs of allergic responses. Both the oral and topical lectin applications to the wounded rats had higher platelet levels than the negative control in both Categories A and B groups indicating that lectin mobilized more platelet factors than the negative control group. With negative control, the CRP levels as a marker of inflammation rose to 3 times its normal folds in Category A group with 7.58±0.85ng/L and 6.06±0.85ng/L for Category B group. On 36 mg/kg amoxicillin administration to the rats from zero week to the 3rd week, there was a decrease in weight at 22.4% compared to the normal control of 31.3%. Both oral and topical administrations showed an increase in weight with 26.4% for 8 mg/kg oral administration and 27.3% for 4 mg/kg topical administration. Both 36 mg/kg amoxicillin and 8 mg/kg lectin oral administration had a two weeks period for the complete healing of the wounded rats. Oral administration of lectin to the wounded rats was nutritional and added weight to the rats.
Automated Assessment of Cardiac Systolic Function From Coronary Angiograms With Video-Based Artificial Intelligence Algorithms
Authors: Avram Robert , Barrios Joshua P. , Abreau Sean , Goh Cheng Yee , Ahmed Zeeshan , Chung Kevin , So Derek Y. , Olgin Jeffrey E. , Tison Geoffrey H. 
Published: May 2023

ImportanceUnderstanding left ventricular ejection fraction (LVEF) during coronary angiography can assist in disease management.ObjectiveTo develop an automated approach to predict LVEF from left coronary angiograms.Design, Setting, and ParticipantsThis was a cross-sectional study with external validation using patient data from December 12, 2012, to December 31, 2019, from the University of California, San Francisco (UCSF). Data were randomly split into training, development, and test data sets. External validation data were obtained from the University of Ottawa Heart Institute. Included in the analysis were all patients 18 years or older who received a coronary angiogram and transthoracic echocardiogram (TTE) within 3 months before or 1 month after the angiogram.ExposureA video-based deep neural network (DNN) called CathEF was used to discriminate (binary) reduced LVEF (≤40%) and to predict (continuous) LVEF percentage from standard angiogram videos of the left coronary artery. Guided class-discriminative gradient class activation mapping (GradCAM) was applied to visualize pixels in angiograms that contributed most to DNN LVEF prediction.ResultsA total of 4042 adult angiograms with corresponding TTE LVEF from 3679 UCSF patients were included in the analysis. Mean (SD) patient age was 64.3 (13.3) years, and 2212 patients were male (65%). In the UCSF test data set (n = 813), the video-based DNN discriminated (binary) reduced LVEF (≤40%) with an area under the receiver operating characteristic curve (AUROC) of 0.911 (95% CI, 0.887-0.934); diagnostic odds ratio for reduced LVEF was 22.7 (95% CI, 14.0-37.0). DNN-predicted continuous LVEF had a mean absolute error (MAE) of 8.5% (95% CI, 8.1%-9.0%) compared with TTE LVEF. Although DNN-predicted continuous LVEF differed 5% or less compared with TTE LVEF in 38.0% (309 of 813) of test data set studies, differences greater than 15% were observed in 15.2% (124 of 813). In external validation (n = 776), video-based DNN discriminated (binary) reduced LVEF (≤40%) with an AUROC of 0.906 (95% CI, 0.881-0.931), and DNN-predicted continuous LVEF had an MAE of 7.0% (95% CI, 6.6%-7.4%). Video-based DNN tended to overestimate low LVEFs and underestimate high LVEFs. Video-based DNN performance was consistent across sex, body mass index, low estimated glomerular filtration rate (≤45), presence of acute coronary syndromes, obstructive coronary artery disease, and left ventricular hypertrophy.Conclusion and relevanceThis cross-sectional study represents an early demonstration of estimating LVEF from standard angiogram videos of the left coronary artery using video-based DNNs. Further research can improve accuracy and reduce the variability of DNNs to maximize their clinical utility.
Implantable Zinc–Oxygen Battery for In Situ Electrical Stimulation‐Promoted Neural Regeneration
Authors: Li Luhe , Li Dan , Wang Yuanzhen , Ye Tingting , He Er , Jiao Yiding , Wang Lie , Li Fangyan , Li Yiran , Ding Jianxun , Liu Kai , Ren Junye , Li Qianming , Ji Jianjian , Zhang Ye 
Published: May 2023

AbstractElectrical stimulation is a promising strategy for treating neural diseases. However, current energy suppliers cannot provide effective power for in situ electrical stimulation. Here, an implantable tubular zinc–oxygen battery is reported as the power source for in situ electrical stimulation during the neural repair. The battery exhibited a high volumetric energy density of 231.4 mWh cm−3 based on the entire anode and cathode in vivo. Due to its superior electrochemical properties and biosafety, the battery can be directly wrapped around the nerve to provide in situ electrical stimulation with a minimal size of 0.86 mm3. The cell and animal experiments demonstrated that the zinc–oxygen battery‐based nerve tissue engineering conduit effectively promoted regeneration of the injured long‐segment sciatic nerve, proving its promising applications for powering implantable neural electronics in the future.
Sex‐specific declines in cholinergic‐targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease
Authors: Shulman Dana , Dubnov Serafima , Zorbaz Tamara , Madrer Nimrod , Paldor Iddo , Bennett David A. , Seshadri Sudha , Mufson Elliott J. , Greenberg David S. , Loewenstein Yonatan , Soreq Hermona 
Published: May 2023

AbstractIntroductionFemales with Alzheimer's disease (AD) suffer accelerated dementia and loss of cholinergic neurons compared to males, but the underlying mechanisms are unknown. Seeking causal contributors to both these phenomena, we pursued changes in transfer RNS (tRNA) fragments (tRFs) targeting cholinergic transcripts (CholinotRFs).MethodsWe analyzed small RNA‐sequencing (RNA‐Seq) data from the nucleus accumbens (NAc) brain region which is enriched in cholinergic neurons, compared to hypothalamic or cortical tissues from AD brains; and explored small RNA expression in neuronal cell lines undergoing cholinergic differentiation.ResultsNAc CholinotRFs of mitochondrial genome origin showed reduced levels that correlated with elevations in their predicted cholinergic‐associated mRNA targets. Single‐cell RNA seq from AD temporal cortices showed altered sex‐specific levels of cholinergic transcripts in diverse cell types; inversely, human‐originated neuroblastoma cells under cholinergic differentiation presented sex‐specific CholinotRF elevations.DiscussionOur findings support CholinotRFs contributions to cholinergic regulation, predicting their involvement in AD sex‐specific cholinergic loss and dementia.
Combining Imine Condensation Chemistry with [3,3] Diaza‐Cope Rearrangement for One‐Step Formation of Hydrolytically Stable Chiral Architectures
Authors: Begato Federico , Penasa Roberto , Wurst Klaus , Licini Giulia , Zonta Cristiano 
Published: May 2023

AbstractDynamic covalent chemistry (DCC) has, in recent years, provided valuable tools to synthesize molecular architectures of increasing complexity. We have also taken advantage of imine DCC chemistry to prepare TPMA‐based supramolecular cages for molecular recognition applications. However, the versatility of this approach has as a major drawback the intrinsic hydrolytic lability of imines, which hampers some applications. We present herein a synthetic strategy that combines the advantages of a thermodynamic‐driven formation of a supramolecular structure using imine chemistry, together with the possibility to synthetize chiral hydrolytically stable structures through a [3,3]‐sigmatropic rearrangement. A preliminary mechanistic analysis of this one‐pot synthesis and the scope of the reaction are also discussed.
Sequence Control in Asymmetric Terpolymerizations of meso‐Epoxides, CO2, and Phthalic Anhydride: Unprecedented Statistical Ester–Carbonate Distributions
Authors: He Guang‐Hui , Ren Bai‐Hao , Wang Shang , Liu Ye , Lu Xiao‐Bing 
Published: May 2023

AbstractThe statistical terpolymerization of epoxides, CO2 and cyclic anhydrides remains challenging, mainly because epoxide/CO2 and epoxide/anhydride copolymerizations typically proceed at considerably different rates. Herein, we report the syntheses of novel chiral terpolymers with unprecedented statistical distributions of carbonate and ester units (up to 50 % junction units) via the one‐pot reaction of cyclohexene oxide, phthalic anhydride, and CO2 under mild conditions using enantiopure bimetallic aluminum‐complex‐based catalyst systems. Notably, all resulting terpolymers exhibited excellent enantioselectivities (≥96 % ee) that were independent of the carbonate–ester distribution. The statistical compositions of the carbonate and ester units in the resulting terpolymers were determined via 1H and 13C NMR spectroscopies. Furthermore, thermal properties were tuned by altering the ester content of the chiral terpolymer without influencing the enantioselective ring‐opening step involving the meso‐epoxide. This asymmetric terpolymerization methodology is also compatible with a variety of meso‐epoxides to afford the corresponding terpolymers with 17 %–25 % junction units and excellent enantioselectivities (94 %–99 % ee). The present study is expected to provide new guidelines for preparing a broad range of biodegradable polymers with excellent enantioselectivities and adjustable properties.
Superprotonic Conductivity of MOFs Confining Zwitterionic Sulfamic Acid as Proton Source and Conducting Medium
Authors: Sharma Amitosh , Lim Jaewoong , Lee Seonghwan , Han Seungwan , Seong Junmo , Bin Baek Seung , Soo Lah Myoung 
Published: May 2023

AbstractA few metal–organic frameworks (MOFs), which typically use strong acids as proton sources, display superprotonic conductivity (≈10−1 S cm−1); however, they are rare due to the instability of MOFs in highly acidic conditions. For the first time, we report superprotonic conductivity using a moderately acidic guest, zwitterionic sulfamic acid (HSA), which is encapsulated in MOF‐808 and MIL‐101. HSA acts not only as a proton source but also as a proton‐conducting medium due to its extensive hydrogen bonding ability and zwitterion effect. A new sustained concentration gradient method results in higher HSA encapsulation compared to conventional methods, producing 10HSA@MOF‐808‐(bSA)2 and 8HSA@MIL‐101. These MOFs show impressive superprotonic conductivity of 2.47×10−1 and 3.06×10−1 S cm−1, respectively, at 85 °C and 98 % relative humidity, and maintain stability for 7 days.
Spectroscopic Signatures of Internal Hydrogen Bonds of Brønsted‐Acid Sites in the Zeolite H‐MFI
Authors: Windeck Henning , Berger Fabian , Sauer Joachim 
Published: May 2023

AbstractThe location of Brønsted‐acid sites (bridging OH groups, b‐OH) at different crystallographic positions of zeolite catalysts influences their reactivity due to varying confinement. Selecting the most stable b‐OH conformers at each of the 12 T‐sites (T=Si/Al) of H‐MFI, a representative set of 26 conformers is obtained which includes free b‐OH groups pointing into the empty pore space and b‐OH groups forming H‐bonds across five‐ or six‐membered rings of TO4 tetrahedra. Chemically accurate coupled‐cluster‐quality calculations for periodic models show that the strength of internal H‐bonds and, hence, the OH bond length vary substantially with the framework position. For 11 of the 19 H‐bonded b‐OH groups examined, our predictions fall into the full width at half maximum range of the experimental signals at 3250±175 cm−1 and 7.0±1.4 ppm which supports previously debated assignments of these signals to H‐bonded b‐OH sites.
Passive‐cooling mica‐TiO2/thermoplastic polyurethane films with enhanced gas‐barrier property
Authors: Zhang Zhenyu , Liu Xiangdong , Zhou Yan , Tian Xinxin , Sun Yinglu , Shi Biru , Zhong Jiahui , Yang Yuming 
Published: May 2023

AbstractPassive cooling technology is currently a hot research topic because it can achieve cooling without external energy input, significantly reduce cooling costs and mitigate global warming. At present, passive cooling technology is mainly used in construction, transportation, electronic equipment, and other fields, but most passive cooling materials do not have gas barrier performance, which limits the application of passive cooling technology in inflatable structures such as gas film buildings, blimp bladders and other fields, so a material that has both passive cooling and gas barrier performance is needed. In this paper, PXTPU composites were prepared by melt blending mica‐TiO2 with thermoplastic polyurethane (TPU). PXTPU not only achieves passive cooling above 10°C with the excellent reflectivity of TiO2 in mica‐TiO2, but also achieves 61.1% or even 74.5% enhancement of gas barrier capacity with the high orientation of lamellar mica in mica‐TiO2. In addition, PXTPU also exhibited good thermal stability and mechanical properties exceeding 31.2 MPa breaking strength and 210.6% breaking elongation. Therefore, PXTPU composites show great potential in inflatable structures for outdoor work, expanding the application field of passive cooling technology.
Effect of multidimensional filler hybridization on the mechanical properties of thermoplastic polyurethane composites prepared by selective laser sintering
Authors: Zhang Cheng , Wu Wei , Hu Huanbo , Rui Zhengguo , Ye Junjian , Shen Hui 
Published: May 2023

AbstractThis paper aims to improve the tensile strength and thermal stability performance of selective laser sintered thermoplastic polyurethane elastomer/spherical alumina/graphene oxide/silicon nitride whisker (TPU/Al2O3/GO/Si3N4ws) composites by investigating the synergistic enhancement of fillers with different dimensions, and solving the problem of excessive porosity, material delamination, and low tensile strength during sintering of semi‐crystalline polymer TPU problems. The results show that the synergistic effect of multidimensional fillers leads to the tensile strength of TPU composites up to 12.1 MPa at 8.9 wt% Al2O3, 0.1 wt% GO and 1.0 wt% Si3N4ws hybrid fillers, which is 38.9% higher than that of pure TPU. In addition, the elongation at break of TPU/Al2O3/GO/Si3N4ws composites was maintained at 254%, which still has good toughness. The effect of fillers on the selective laser sintering (SLS) process, thermal stability, melting, and crystallization behaviors of the composites was also investigated in this work. In general, the multidimensional filler compounding synergistically constructing a three‐dimensional network structure has some improvement on the thermomechanical behavior of TPU composites with a fixed mass component addition.
Fabrication of molecularly imprinted cotton fibers for quantification of streptomycin in honey samples
Authors: Zengin Adem , Badak M. Utku , Bilici Mustafa , Aktaş Nahit 
Published: May 2023

AbstractStreptomycin is a type of aminoglycoside used in treatment of several infections and with serious side effects in humans and animals, such as ototoxicity and nephrotoxicity. In the present study, we focused on the preparation of streptomycin‐imprinted cotton fiber for rapid, sensitive and selective quantification of streptomycin in honey samples. The imprinted cotton fibers were characterized by attenuated total reflectance‐Fourier transform spectroscopy, scanning electron microscopy, and x‐ray photoelectron spectroscopy. In addition, the imprinted cotton fibers showed high adsorption capacity (95.4 mg/g) with an imprinting factor of 3.69 and had satisfactory regeneration ability of up to 10 regenerations without significant change in adsorption capacity. The imprinted cotton fibers showed good linearity with a correlation coefficient of 0.9989 and limit of detection was determined to be 0.29 ng/mL for streptomycin in honey samples. The proposed method showed acceptable recovery ranges (98.0%–100.3%) with lower inter‐day and intra‐day precisions. Moreover, the performance of the proposed method was compared to the ELISA method. The results showed that the present method is as sensitive and selective as ELISA. It is concluded that the imprinted cotton fibers could be a potential alternative to antibiotic quantification based on traditional immunoassays or chromatographic techniques.