bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dermatological Findings in Children’s Films
Authors: Momin Fareen , Reese Vail , Wagner Jr. Richard F. 
Published: May 2023

Introduction: Filmmakers use dermatologic findings to help the audiences decipher between ‘good’ and ‘bad’ characters by portraying villains with recognizable skin findings. The objective of this study was to analyze 18 Disney live-action movies in relation to their earlier animated releases to determine whether there were changes or correlation about how the industry portrayed certain characters based on their roles as heroes or villains.
Methods: To better understand how the use of dermatological findings are changing in the film industry, eighteen Disney live-action movies in relation to their earlier animated releases were compared for changes or correlation on how the industry portrays certain characters based on their roles as heroes or villains.
Results: Film antagonists were depicted with significantly more dermatologic findings than protagonists (p<0.0001). In addition, the frequency of periorbital hyperpigmentation (p=0.02) and nasolabial folds (p=0.05) were significantly higher in antagonists verses protagonists.
Conclusion: These findings have important implications about the dermatological content of movies directed toward children. Findings of this study suggest filmmakers are continuing to use common dermatological findings to indirectly portray characters as ‘good’ or ‘bad.’
Five Years Later: Continuing Disparity in the Geographic Density and Distribution of U.S. Dermatologists
Authors: Nguyen Christopher , Nguyen Quoc-Bao , Lauck Kyle , Hebert Adelaide 
Published: May 2023

Objectives: A discrepancy exists in the geographical distribution of dermatologists across the United States (US). The aim of this study was to reexamine the current geographical density of dermatologists to describe any changes compared to date from 5 and 12 years ago.
Methods: Membership data from the 2021 American Academy of Dermatology (AAD) database were retrieved to characterize the distribution of dermatologists in 3-digit zip code areas.
Results: Out of 712 populated zip codes with dermatologists, 510 (71.6%) had less than 4 dermatologists per 100,000, as compared to 515 (72.3%) in 2016 (– 0.19% CAGR). The dermatologist density of the 100 most populated areas (M = 4.5 dermatologists per 100,000, SD = 3.3) and 100 least populated areas (M = 1.6 dermatologists per 100,000, SD = 6.2) were significantly different (P < 0.0001).
Conclusion: This analysis provides continued trends to compare to previous studies performed in 2016 and 2009. The highest and lowest density areas were similar to results from previous studies. The results indicate an enduring and significant maldistribution of dermatologists in the US.
Clinician satisfaction with treatment outcomes among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S in PROSES study: Analysis by concomitant medication use
Authors: Graber Emmy , Baldwin Hilary , Alexis Andrew F. , Del Rosso James , Fried Richard G. , Harper Julie C. , Hebert Adelaide , Kircik Leon , Rieder Evan A. , Stein Gold Linda , Narayanan Siva , Koscielny Volker , Kasujee Ismail 
Published: May 2023

Introduction: The objective of this analysis was to evaluate clinician satisfaction with treatment outcomes, stratified by the use of concomitant acne medications, among AV patients administered sarecycline in community practices across the U.S.
Methods: A single-arm, prospective cohort study (PROSES) was conducted with moderate-to-severe non-nodular AV patients >9 years who were prescribed sarecycline in real-world community practices in the US. Clinician satisfaction with sarecycline treatment outcomes was assessed on a five-point adjectival response scale (1 (very dissatisfied)-5 (very satisfied)). Proportion of patients for whom clinicians reported very satisfied/satisfied was analyzed, stratified by the use of any concomitant AV medication during the study (Yes vs. No (monotherapy)).
Results: A total of 253 AV patients completed the study (adults 60.08% (mean age 26.63); pediatric 39.92% (mean age 14.81); female: 66.40%; white/Caucasian: 68.38%, African American: 8.70%; other races: 22.92%). Per IGA at baseline, 86.56% & 13.44% had moderate and severe AV, respectively. Key concomitant treatments for AV observed during the study included: topical retinoids (24.51%), topical antibiotics (13.44%), benzoyl peroxide (5.93%), topical dapsone (5.14%) and other (17.00%; predominantly adapalene/benzoyl peroxide). Half of the patients (49.80%) were on sarecycline monotherapy (i.e., did not use any concomitant treatments for AV).
In the overall study cohort, at week-12, clinicians reported very satisfied/satisfied with sarecycline treatment outcomes for 88.14% of patients. At week-12, clinician satisfaction (very satisfied/satisfied) was 88.98% among patients using concomitant AV medications, and 87.30% among patients using no concomitant AV medications (i.e., on sarecycline monotherapy).
Conclusion: Within the study cohort administered sarecycline, a narrow-spectrum, tetracycline-derived antibiotic, for 12 weeks, overwhelming majority of clinicians were very satisfied/satisfied with sarecycline treatment outcomes at week-12, and clinician satisfaction was similar among patients on sarecycline monotherapy and those on concomitant AV medications.
Parámetros bioquímicos y sanguíneos de la rata de laboratorio (Rattus norvegicus): revisión de la literatura
Authors: Vargas Mamani Juan José 
Published: May 2023

En la presente revisión se resumen los principales parámetros sanguíneos, bioquímicos e inmunológicos de Rattus norvegicus contrastándolos con el del ser humano, de esta forma el interesado podrá apreciar la diferencia entre los valores normales de dos especies diferentes de mamíferos. La rata de laboratorio comparte con el ser humano muchos valores normales en común, pero hay excepciones que deberán tenerse en cuenta al momento de usar ese animal como modelo de investigación biomédica. Los datos fueron obtenidos pensando en la rata macho y el hombre como géneros elegidos.
Propuesta de compuestos fenólicos presentes en el extracto metanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts “panisara”
Authors: Zelada Mallco Diana J. , Bonilla Rivera Pablo E. 
Published: May 2023

Objetivos. Proponer compuestos fenólicos presentes en el extracto metanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts“panisara”. Materiales y métodos. Se preparó mediante maceración un extracto metanólico de las hojas de Clinopodium pulchellum (Kunth) Govaerts“panisara”, se determinó la solubilidad mediante la disolución de extracto en solventes de polaridad creciente. Se detectó algunos componentes químicos mediante un screening fitoquímico empleando gelatina, tricloruro férrico, reacción de Mayer, reacción de Shinoda, entre otros. Se realizó cromatografía en capa fina, revelándose por aspersión con reactivos cromogénicos y se propone posibles estructuras de componentes mediante espectroscopía UV. Resultados. El extracto metanólico presentó buena solubilidad en solventes de alta y mediana polaridad. El screening fitoquímico dio resultados positivos para la presencia de compuestos fenólicos y compuestos nitrogenados: flavonoides, alcaloides y glicósidos. Conclusión. Se propuso la estructura química de tres flavonoides obtenidos del extracto metanólico de hojas de Clinopodium pulchellum (Kunth) Govaerts “panisara”.
La importancia de la investigación en medicina integrativa
Authors: Equipo editor de la Revista Peruana de Medicina Integrativa  
Published: May 2023

La medicina integrativa propugna la articulación de las alternativas de diagnóstico y tratamiento convencionales con las de la medicina alternativa, tradicional y complementaria; considerando todos los aspectos del paciente y de su estilo de vida desde un enfoque holístico(1). Una visión articuladora es, muchas veces, irremediablemente necesaria para la atención de la salud en un país como el Perú, con un fuerte y rico trasfondo cultural. La población peruana acoge sistemas tradicionales de salud a los que el personal de salud encargado de su atención debe adaptarse para preservar una correcta salud intercultural(2).
Development of Android-Based Learning Media on Operations of Integers
Authors: Afifah Nur , Wintarti Atik 
Published: May 2023

The ongoing digitalizing education makes the use of technology is necessary to develop the learning media. Therefore, this research describes the development process of android-based learning media with the ADDIE model and find out the validity and practicality of it. The material is operations of integers because it’s a prerequisite for many other mathematics material. The research subjects were nine 7th-grade students in SMPN 5 Jombang since they had never been given the kind of math learning media based on Android in that school. They were consist of three categories of low, medium, and high mathematical ability to determine whether all types of students can understand the presence of media to achieve their learning mastery. The data analyzed using qualitative descriptive and quantitative data analysis techniques. The result of this research and development are : 1) The Android-based learning media called Math Moist; 2) The learning media is very valid based on the results of media and material validation with a validity percentage of 83.541%; 3) The media is very practical based on the student's response questionnaire scores, with a percentage of practicality is 88.7301%; 4) Based on the result of learning outcomes test, 8 of the 9 research subjects have completed learning after using media.
Keywords: development, media, android-based, ADDIE, integer.
Penerapan Pembelajaran Daring pada Mata Pelajaran Matematika Materi Barisan dan Deret untuk Kelas XI
Authors: Pratama Farid Aditya , Wintarti Atik 
Published: May 2023

Pembelajaran daring merupakan salah satu bentuk pemanfaatan teknologi dalam pembelajaran. Pembelajaran daring memanfaatkan internet untuk memudahkan penyampaian materi oleh guru dan memberikan ruang lebih untuk siswa dalam belajar. Penggunaan sumber belajar yang relatif mudah untuk diakses dan terdapat berbagai media pembelajaran yang menarik dan inovatif merupakan kelebihan dari pembelajaran daring. Dalam pembelajaran daring, sumber belajar dan media pembelajaran dapat diintegrasikan dalam satu tempat yang dikenal dengan Learning Management System (LMS). Terdapat berbagai macam LMS yang tersedia, salah satu contoh LMS tersebut adalah Google Classroom. Penelitian ini bertujuan untuk mendeskripsikan penerapan pembelajaran daring pada mata pelajaran matematika materi barisan dan deret ditinjau dari hasil belajar siswa. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kuantitatif yang dilaksanakan di kelas XI B SMA Plus Ar Rahmat Bojonegoro yang terdiri dari 25 siswa. Instrumen penelitian yang digunakan terdiri atas LMS, angket pengelolaan pembelajaran, angket respon siswa, RPP, LKPD, dan ujian yang berupa tes untuk mengukur tingkat pemahaman siswa terkait materi yang diajarkan. LMS yang digunakan dalam penelitian ini adalah Google Classroom dengan alamat situs https://classroom.google.com/c/NTUwNTkyNTU5NDEy?cjc=ywcuuqp. LMS divalidasi oleh ahli media dan mendapatkan kriteria sangat baik dengan persentase 87,5%. Hasil pada penelitian ini menunjukkan kemampuan pengelolaan pembelajaran masuk pada kriteria sangat baik dengan persentase 89,5%. Respon siswa terhadap pembelajaran daring masuk pada kriteria baik dengan persentase 73,94%. Hasil belajar siswa dengan jumlah siswa sebanyak 25 siswa dinyatakan tuntas dengan persentase ketuntasan belajar 84%.
Kata Kunci: pembelajaran daring, Learning Management System, barisan dan deret.
Development of Student Worksheets Electronic (E-LKPD) for Geometry Transformation Materials
Authors: CHOFIFAH NOR , Wintarti Atik 
Published: May 2023

The purpose of this study is to develop an e-LKPD using a Live Worksheets with GeoGebra-assisted for geometric transformations, especially translation. The translation sub-topic was chosen because many students still need help finding translation concept. The type of research carried out in development research to produce e-LKPD using the ADDIE method consists of stages Analysis, Design, Development, Implementation, and Evaluation. The test subjects in this study were 15 students with high, medium, and low math ability categories. Subjects are divided into three categories to determine students' understanding of the e-LKPD so that they are able to achieve learning mastery. Students from junior high school (SMP Negeri 39 Surabaya) were selected as subjects because they had never used GeoGebra-assisted e-LKPD. The data collection instruments in the study consisted of validation sheets, learning outcomes tests (THB) and student response questionnaires. The results of this study indicate that the validation results with an average score of 3.73, which means that the e-LKPD on translation is included in the very valid criteria and is feasible to use. The analysis of the use of e-LKPD shows that the average student response is 3.39, which means e-LKPD is positive and practical. Based on the test scores for learning outcomes, 14 of the 15 research subjects scored pass the KKM, so using e-LKPD can help students learn about translation materials. Thus the translational e-LKPD using a GeoGebra-assisted Live Worksheets are valid, practical and effective.
Keywords: e-LKPD, Geometry Transformation, Translation, Geogebra, Live Worksheets.
Legal Protection against Patent and Intellectual Property Rights Violations Amidst COVID-19
Authors: Poungjinda Wachiraporn , Pathak Shubham , Bimbilovski Ivan 
Published: May 2023

The concept of legal principles for intellectual property (IP) protection is related to the adequate marketing of drug patents to protect patent rights. The objective of this research is to understand and analyze the factors affecting the market concerning international law, treaties, acts, and declarations, leading to encouraging creativity, production, increased investment, especially amidst the COVID-19 pandemic. The qualitative methodology provided for an in-depth understanding and analysis of primary and secondary research data gathered from key informant interviews and published literature. The collected data were analyzed with Strength, Weakness, Opportunity, and Threats (SWOT), a Delphi panel, and Correct, Adapt, Maintain, and Explore (CAME) analysis. The results found legal problems concerning the lack of rules to protect the rights and freedoms damaged by the monopoly on drug patents, complexities in the process of importing medicinal compounds, and how to access information with limited accessibility during COVID-19. Therefore, it is advisable to amend the law to curtail monopolies and to enact a law that prescribes rules for importing medicinal compounds to produce generic drugs in the country, including identifying the status of the patent holders. The research further paves the way for utilizing micro level research to be conducted in the development of intellectual property rights. Doi: 10.28991/ESJ-2023-SPER-016 Full Text: PDF
Identification and Characterization of Carnitine Palmitoyltransferase 1A (CPT1A) Gene in European Sea Bass (Dicentrarchus labrax)
Authors: ÖZCAN GÖKÇEK Emel , IŞIK Raziye 
Published: May 2023

Objective: CPT1A intervenes in the access of the long-chain fatty acyl-CoA to the mitochondrial matrix. In this study, we conducted the genetic polymorphisms of the partial sequence of the CPT1A gene in European sea bass (Dicentrarchus labrax) that were cage cultured in the Aegean Sea.
Material and Methods: Genomic DNA was isolated from 100 European sea bass individuals. After amplifying a partial region of the CPT1A gene by thermal cycler, PCR products were sequenced via Sanger method.
Results: We detected two SNPs in partial sequence of the CPT1A gene in European sea bass. TT, TA and AA genotypes were observed for CPT1A g.2080T>A locus with frequencies of 27.04, 49.92 and 23.04%, respectively. The frequencies of the g.2216A>G locus as AA, AG and GG were found to be 1.2, 19.58 and 79.21%, respectively. The CPT1A g.2080T>A locus was in HWE, whereas the g.2216A>G locus was not in HWE.
Conclusion: European sea bass has a high commercial value. These findings suggest that two SNPs in the CPT1A gene could be used for genomic selection programs related to fatty acid composition in European sea bass.
Keywords: Fatty acid, SNP, sea bass, variation
Correlation processing of incoherent scattering signal using multichannel device
Authors: Emelyanov L.Ya. , Pulayev V.А. , Rogozhkin E.V. 
Published: May 2023

A method of correlation processing and the appropriate structure of the updated correlator operating as a part of the incoherent scatter radar in real time are proposed. The use of additional correlation channels makes it possible to reduce the error in determining the autocorrelation functions of the incoherently scattered signal and, as a consequence, to improve the accuracy of ionosphere parameters measurement without degrading height and temporal resolutions.
Transformation of the airy pulse at temporary jump of the dielectric permittivity of the medium
Authors: Nerukh A.G. , Kuryzheva O.V. 
Published: May 2023

The spatio-temporal problem of interaction of the Airy electromagnetic pulse and a plane dielectric layer is solved in the case of a permittivity sharp change in a layer at zero moment of time. Expressions for the field inside the layer are obtained and the influence of the starting parameter on the position of the pulse inside the layer is shown. The evolution of the pulse in media with different refractive index is analyzed. A comparative analysis of the interaction of the Airy pulse with a plane layer between two dielectric media with a dielectric layer is carried out. The influence of pulse reflections from the layer boundaries on its shape and location is analyzed. From the analysis of the obtained results it follows that the choice of the initial space-time parameter affects the location of the pulse in the layer, and the transition of the signal to a medium with a larger (lower) permittivity results in the amplitude increase of oscillations and the main lobe shape change.
Investigation of cross-platform realizations of stream symmetric ciphers
Authors: Kuznetsov A.A. , Frolenko V.O. , Eremin E.S. , Ivanenko D.V. 
Published: May 2023

Modern symmetric stream ciphers Enocoro, Decim, Grain, HC, MUGI, Mickey, Rabbit, RC-4, Salsa20, SNOW2.0, Sosemanuk, Strumok, Trivium, and a block cipher AES, which can be used in streaming encryption modes, are being researched. The main results of testing the rate of formation of a key stream with cross-platform implementation of encryption algorithms in the Java programming language on operating systems Windows 10 (x64), Debian (Kali) and Android (x64) are presented. Testing was conducted on the portable personal computer (Intel Pentium 3550m 2.3GHz, RAM 4GB (1600МHz)) and on the mobile device, in particular, on the smartphone (Samsung galaxy S7).
Fractal study of the mechanical properties of hardened hydraulic hammer parts
Authors: Hlushkova Diana , Volchuk Volodymyr , Saenko Vladislav , Efimenko Andrey 
Published: May 2023

Abstract. Problem. Intensive abrasive wear of hydraulic hammer parts during operation leads to a decrease in their residual life. Since the existing methods of volumetric and surface strengthening of parts do not give a significant effect, the involvement of the ion-plasma chrome plating method has become relevant. Methodology. High-quality chrome coatings are obtained at a substrate temperature of at least 80–100°C. On the basis of experimental studies, the effect of ion-plasma chromium plating on the wear resistance and mechanical properties of hydraulic hammer parts was established, and structural changes in the material were also analyzed. The technology of ion-plasma chrome plating ensures the operation of hardened parts without chipping and crushing and increases their wear resistance by 1.75 times. Zones of structural transformations, characteristic of secondary hardening phenomena, are noted in the areas of damage to the parts. Results. Fractal theory, in particular, multifractal analysis using the Rényi equation, was used to analyze the non-homogeneous surface of hydraulic hammer parts (hammers, picks). The sorbitol structure of the bran and peaks was considered at ´ 100. Models describing the relationship between mechanical properties and multifractal characteristics of the structure were obtained: homogeneity of D600, orderliness (hidden periodicity D = D1-D600 , regularity K = D-600-D600. Adequacy of the models is confirmed by Durbin-Watson statistics at the level of 2.62 and 3.12. The sensitivity of the studied multifractal statistical characteristics of cementite to the strength properties sB (0.80) and s0.2 (0.96), as well as ferrite to plastic properties d (0.97) and y (0.97) was established. Practical value. The obtained results allow us to use this approach as an express method of non-destructive control when predicting the mechanical properties of the relevant parts of the hydraulic hammer after ion-plasma chrome plating.
Method of generating ORM models software code based on relational database schemes
Authors: Dolhopolov Kyrylo , Imanhulova Zulfiia 
Published: May 2023

Abstract. Problem. Databases and data stores are an important part of any system, regardless of the field of application. It is at this level that all system information is stored, such as a list of online store products, user personal data, system configuration parameters, etc. In addition, they allow to structure information in the desired format. Although the use of databases is associated with obvious advantages, it has some disadvantages, in particular the process of designing them and integrating their software code is labor-intensive and time-consuming. This problem is usually attempted to be circumvented by using ORM libraries, which provide a convenient programming interface for performing basic queries. But the process of setting up an ORM library including developing ORM models still takes a lot of time. Goal. The purpose of the work is to develop an algorithm for the automatic generation of software code for ORM models based on the selected ORM library and the data scheme presented in the form of a configuration file. To achieve the goal, it is necessary to establish the optimal representation of the data scheme in text format, to determine the structure of the data configuration scheme and to describe all stages of the generation of software code for ORM models. Methodology. System approach, analysis of existing methods of visual design, formats of text representation of configuration data and methods of configuration data storing. Results. The developed method for software code generation for the selected ORM library based on the scheme of the relational database provides the user with the opportunity to obtain a qualitatively designed software code with minimal time expenditure. Originality. The developed method implements a unique approach which allows to create program code for various ORM libraries, supports the syntax and features of a specific programming language, and provides work with data schemas from various relational databases. Practical value. Developed generation algorithm can be used as part of the software in which the automated process of preparing the data schema in the appropriate text formatted form will be implemented. As a result, such a web-application will represent a platform for working with the data layer for IT professionals.