bluuebunny/crossref_metadata_2025_split huggingface dataset:
Land cover changes with the development of anaerobic digestion for biogas production in France
Authors: Levavasseur Florent , Martin Lucie , Boros Léa , Cadiou Jeanne , Carozzi Marco , Martin Philippe , Houot Sabine 
Published: February 2023

AbstractAnaerobic digestion is developing in various countries worldwide to produce renewable energy. In addition, the resulting digestates provide readily available nutrients when applied to cropping systems as fertilizers. The introduction of a biogas plant on a farm can induce land cover changes, in relation to the production of feedstock for the biogas plant and/or to the modification of the farming system. The aim of this study was therefore to characterize and quantify the land cover changes in farms associated with biogas plants in France. We combined two national spatialized databases: the Land Parcel Identification System (yearly French land cover at the parcel scale with farm identifier per parcel) and the SINOE database (biogas plant location and year of start‐up). We showed that, on average, the changes were limited, with an increase in maize areas (+3.4% of the total farm areas) compensated by a decrease in wheat and rapeseed areas (−1.8% and −1.9%, respectively), but with a certain variability. The French regulation and market limiting the use of dedicated energy crops seems to have limited land cover changes in France compared to other countries. However, we elaborated a typology of land cover changes and characterized five clusters of farms across the country. The main one (67% of the farms) corresponded to unchanged land cover after the introduction of a biogas plant. The four other clusters showed contrasting changes, for example, an increase or a decrease in grassland areas, a strong increase in maize areas, or a replacement of winter wheat by winter barley. The diversity and the driving factors behind these changes deserve to be better studied and understood through further farmer surveys.
Zwischen Konvention und Eigen‐Art: Text in Gerhard Richters Comic Strip
Authors: Ludewig Julia 
Published: February 2023

AbstractDieser Aufsatz geht der Schrift in Gerhard Richters 1962 geschaffenem Werk Comic Strip nach. Auf vielen Seiten des avantgardistischen Comics begegnet uns eine ebenso dominante wie unlesbare Handschrift. Wurden diese Schriftblöcke bislang als provozierendes beziehungsweise ästhetisch ansprechendes Ornament abgetan, biete ich hier eine andere Lesart an. Neben medien‐ und kunstwissenschaftlichen Zugängen zu Schrift lege ich besonderes Augenmerk auf textlinguistische Impulse, die noch wenig Eingang in die Comicanalyse gefunden haben. Aufbauend auf einem close reading führe ich aus, wie Richter weniger Schrift, als vielmehr Text und Textsorten zitiert, die wir dank ihrer graphischen Oberflächensignale erkennen. Mithilfe makrotypographischer Merkmale karikiert Richter so unterschiedliche Gattungen wie Wissenschaftstexte, Briefmanuskripte und buchhalterische Listen. Zudem bespreche ich generisch unterdeterminierte Textblöcke, die Richter als flächiges Gewebe refunktionalisiert, ohne jedoch ihre Herkunft als Text zu leugnen. Damit entwickelt Comic Strip die skripturalen Experimente anderer Comics weiter und stellt uns, wortwörtlich, die Multimodalität aller Texte vor Augen.
EPA's Unprecedented Interim Drinking Water Health Advisories for PFOA and PFOS
Authors: Cotruvo Joseph A. , Goldhaber Susan B. , Cohen Andrew J.B. 
Published: February 2023

AbstractPer‐ and polyfluoroalkyl substances (PFAS) are persistent and widely distributed in the environment from commercial products and waste process residues, including in surface waters usually at low parts per trillion (ppt) levels. Groundwaters near contaminated locations can have higher parts per trillion or parts per billion (ppb) concentrations. Interim EPA Drinking Water Health Advisories (HAs) for perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) that were originally 70 ppt were recently reduced to 0.004 and 0.020 ppt, respectively. Final HAs for perfluorobutane sulfonic acid and its potassium salt (PFBS) and hexafluoropropylene oxide (HFPO) dimer acid and its ammonium salt (“GenX chemicals”) were established at 2000 and 10 ppt, respectively. The minimum reporting levels (MRLs) for PFOA and PFOS are currently 4 ppt. The scientific basis for these very low and unmeasurable HA values for PFOA and PFOS is debatable and up to about five orders of magnitude below many other worldwide national recommendations (e.g., Australia, UK, Canada), which are in the range of 100 ppt and above.
miR‐144‐3p represses hepatocellular carcinoma progression by affecting cell aerobic glycolysis via FOXK1
Authors: Xing Binyu , Shen Cunyi , Yang Qinling , Wang Zheng , Tan Wenjun 
Published: February 2023

AbstractAerobic glycolysis is a unique mark of cancer cells, which enables therapeutic intervention in cancer. Forkhead box K1 (FOXK1) is a transcription factor that facilitates the progression of multiple cancers including hepatocellular carcinoma (HCC). Nevertheless, it is unclear whether or not FOXK1 can affect HCC cell glycolysis. This study attempted to study the effect of FOXK1 on HCC cell glycolysis. Expression of mature miRNAs and mRNAs, as well as clinical data, was downloaded from The Cancer Genome Atlas‐Liver hepatocellular carcinoma (TCGA‐LIHC) dataset. FOXK1 and miR‐144‐3p levels were assessed through quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot. Targeting of the relationship between miR‐144‐3p and FOXK1 was verified via a dual‐luciferase assay. Pathway enrichment analysis of FOXK1 was performed by Gene Set Enrichment Analysis (GSEA). Cell function assays revealed the glycolytic ability, cell viability, migration, invasion, cell cycle, and apoptosis of HCC cells in each treatment group. Bioinformatics analysis suggested that FOXK1 was upregulated in tissues of HCC patients, while the upstream miR‐144‐3p was downregulated in tumour tissues. Dual‐luciferase assay implied a targeting relationship between miR‐144‐3p and FOXK1. Cellular experiments implied that silencing FOXK1 repressed HCC cell glycolysis, which in turn inhibited the HCC malignant progression. Rescue assay confirmed that miR‐144‐3p repressed glycolysis in HCC cells by targeting FOXK1, and then repressed HCC malignant progression. miR‐144‐3p/FOXK1 axis repressed malignant progression of HCC via affecting the aerobic glycolytic process of HCC cells. miR‐144‐3p and FOXK1 have the potential to become new therapeutic targets for HCC, which provide new insights for HCC treatment.
Nutritional, functional, and ethno‐medical properties of sweet corn cob: a concurrent review
Authors: Islam Fakhar , Imran Ali , Afzaal Muhammad , Saeed Farhan , Asghar Aasma , Shahid Sumaira , Shams Arooj , Zahra Syeda Mahvish , Biswas Sunanda , Aslam Muhammad Arslan 
Published: February 2023

SummaryThe corn cob is still a significant component of the corn residue. It is estimated that maize cob accounts for 40–50 percent of total corn production. Corn cob is considered an agriculture waste (by‐product of sweet corn). This by‐product causes environmental pollution, which produces health problems. Its phytochemicals and prebiotic potential provide large benefits for humans when it is consumed. Therefore, corn cob has functional properties such as antioxidant, antimicrobial, anticoagulant, anticancer and reduces the blood glucose level. Corn cob may be used as opportunistic raw material in food products and other possible applications. Current review explained the nutritional composition of corn cob and its possible health benefits. In conclusion, corn cobs have the potential for the development of value‐added products, which are gluten free and also contribute to flourish business of food development and nutraceutical manufacturing industries.
Antioxidant and antibacterial activities of indigenous plant leaf ethanolic extracts and their use for extending the shelf‐life of Nile tilapia (Oreochromis niloticus) mince
Authors: Sinlapapanya Pitima , Sumpavapol Punnanee , Aluko Rotimi E. , Nuthong Pornpot , Zhang Bin , Benjakul Soottawat 
Published: February 2023

SummaryLong pepper (LP), soursop (SS), green vein kratom (GK), and red vein kratom (RK) leaf ethanolic extracts were prepared using an ultrasonic device, followed by dechlorophyllization by the sedimentation process. Antioxidant and antimicrobial activities of the extracts were studied. Highest yield and total phenolic content were found in RK extract (P < 0.05). In general, RK extract showed the lowest minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) towards four bacteria (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Shewanella sp.), when compared with other extracts. Addition of GK extract at 600 mg kg−1 retarded chemical changes and lowered microbiological growth in Nile tilapia mince within 12 days at 4 °C. Lipid oxidation was also impeded with the aid of GK extract. Therefore, GK extract inhibited both spoilage and pathogenic bacteria, and prevented lipid oxidation, thus extending the shelf‐life of tilapia mince.
Green synthesis of copper nanoparticles fromNigella sativaseed extract and evaluation of their antibacterial and antiobesity activity
Authors: Kumar Mukul , Kaushik Deepika , Kumar Ashwani , Gupta Prerna , Proestos Charalampos , Oz Emel , Orhan Elif , Kaur Jasjit , Khan Mohammad Rizwan , Elobeid Tahra , Bordiga Matteo , Oz Fatih 
Published: February 2023

SummaryIn this study, the copper nanoparticles were synthesized using various concentrations (5%, 6 %, 8%, and 10%) ofNigella sativaseed extracts, and their antibacterial and antiobesity effect was evaluated. The optimum particle size (98.23 nm) of nanoparticles was obtained at an extract concentration of 8%. FTIR results confirmed the functional groups responsible for copper ion reduction, The synthesized nanoparticles exhibited high antibacterial activity againstPseudomonas aeruginosaandEscherichia colihaving inhibition zone of 25 mm and 24 mm, respectively. Significantly (P< 0.005) percent lipase and amylase inhibition assay of copper nanoparticles confirmed their antiobesity activities.
Migration and livelihood constellations: Assessing common themes in the face of environmental change in Somalia and amongAgro‐Pastoralpeoples
Authors: Griffith David , Muneepeerakul Rachata , Guerry Genevieve , Cabrero Alvaro Carmona , Johnson Jeffrey C. , Munoz‐Carpena Rafael , Puma Michael , Lall Upmanu , Homayounfar Mehran 
Published: February 2023

AbstractResearch on migration has become more challenging due to at least four factors: (1) more complex migration traditions; (2) the development of migration economies that engage many types of migrants from ever more social and cultural backgrounds; (3) increasing likelihood of climate change‐driven environmental migration; and (4) increasing likelihood of conflict‐based migration in some contexts. These developments have shaken economic theories of migration and have encouraged interdisciplinary, methodologically mixed, qualitative and quantitative research and analysis. From a review of the literature, we have gleaned 11 common themes about environmental, economic and conflict migration that we differentiate by process (migration behaviours that are still evolving) and patterns (migration behaviours that have become customary). We then consider how positive and negative dimensions of migration can be captured and represented with close attention to livelihood constellations (multiple economic activities combined by individuals, households and families). Finally, focusing on Somalia and agro‐pastoral peoples generally, where recent environmental and conflict migration have been added to decades of economic migration and centuries of seasonal, environmental migration associated with pastoralism, we combine historical and qualitative work to demonstrate the value of a livelihood constellation perspective.
Effectiveness of telehealth interventions on psychological outcomes and quality of life in community adults during the COVID‐19 pandemic: A systematic review and meta‐analysis
Authors: Hao Xiaonan , Qin Yuan , Lv Miaohua , Zhao Xuetong , Wu Shuang , Li Kun 
Published: February 2023

AbstractPhysical distancing and contact restrictions have been implemented in most countries and territories due to the rapid spread of SARS‐CoV‐2. This has caused physical, emotional, and psychological distress for adults living in the community. Diversified telehealth interventions have been widely applied in health care and have proven to be cost‐effective and well accepted by patients and health professionals. Currently, the effectiveness of telehealth interventions on psychological outcomes and quality of life among community adults during the COVID‐19 pandemic remains unclear. A literature search was conducted using PubMed, PsycINFO, CINAHL, EMBASE, MEDLINE, and the Cochrane Library from 2019 to October 2022. Twenty‐five randomized controlled trials with 3228 subjects were finally included in this review. Two independent reviewers performed the screening, extraction of key data points, and appraisal of the methodological quality. There were positive effects of telehealth interventions on anxiety, stress, loneliness, and well‐being among community adults. Participants who were women or older adults were more likely to recover from negative emotions, increase well‐being, and improve quality of life. The real‐time and interactive interventions and remote cognitive‐behavioural therapy (CBT) may be better choices during the COVID‐19 pandemic. Based on the findings of this review, health professionals have more options and alternatives for delivering telehealth interventions in the future. Rigorously designed randomized controlled trials (RCTs) with higher statistical power and long‐term follow‐up should be conducted in the future to strengthen the currently weak evidence.
Microstructures and physical properties of sol–gel derived Ba2FeMnO6 double perovskite
Authors: Wu Zhiwei , Yi Kang , Tang Qingkai , Gu Jiayuan , Ding Jie , Chen Liangdong , Zhu Xinhua 
Published: February 2023

AbstractWe report microstructures and physical (dielectric, magnetic, and optical) properties of sol–gel derived Ba2FeMnO6 (BFMO) double perovskite powders. The BFMO powders belong to hexagonal crystal structure with P‐6m2 space group. SEM images reveal the powders are nearly homogeneous distribution with spherical morphology and average particle size of 300 nm. Energy‐dispersive spectra gave out the molar ratio of the Ba:Fe:Mn elements equal to 2.16:1.00:1.00. FTIR spectrum verified the [FeO6] and [MnO6] octahedra present in the powders. X‐ray photoelectron spectroscopy spectra identified the chemical valence states of the constituent elements. The BFMO ceramics displayed a strong frequency dispersion dielectric behavior. A relaxor‐like dielectric behavior appeared around ∼475 K due to the contributions of oxygen vacancies of and the  defect dipoles. A ferrimagnetic behavior was observed in the powders at 5 K with MS = 0.14 μB/f.u. and HC = 1.51 kOe. The magnetic Curie temperature (TC) was 381 K, whereas the Neel temperature (TN) was 31 K. The ferrimagnetic behavior is governed by the Mn3+–Fe4+ double‐exchange interaction via the mediated oxygen between them. The BFMO powders have a direct optical bandgap of 1.65 eV, which originates from the electron transferring from O 2p to Mn 3d (and/or Fe 3d) levels. The unique combination of high temperature ferrimagnetism and semiconductivity in the BFMO powders makes them particularly appealing for magnetic spintronics and photovoltaics.
The UK psychiatrists' experience of rationalising antipsychotics in adults with intellectual disabilities: A qualitative data analysis of free‐text questionnaire responses
Authors: (Shoumi) Deb Shoumitro , Limbu Bharati , Nancarrow Tom , Gerrard David , Shankar Rohit 
Published: February 2023

AbstractBackgroundOverprescribing of off‐licence psychotropic medications, particularly antipsychotics, for challenging behaviours in people with intellectual disabilities without a psychiatric disorder is a significant public health concern. In the United Kingdom, the National Health Service England launched an initiative in 2016, ‘STopping Over‐Medication of People with learning disabilities, autism or both (STOMP)’, to address this concern. STOMP is supposed to encourage psychiatrists in the United Kingdom and elsewhere to rationalise psychotropic medication use in people with intellectual disabilities. The current study aims to gather UK psychiatrists' views and experience of implementing the STOMP initiative.MethodsAn online questionnaire was sent to all UK psychiatrists working in the field of intellectual disabilities (estimated 225). Two open‐ended questions allowed participants to write comments in response to these questions in the free text boxes. One question asked about the challenges psychiatrists faced locally to implement STOMP, and the other asked for examples of successes and positive experiences from the process. The free text data were analysed using a qualitative method with the help of the NVivo 12 plus software.ResultsEighty‐eight (estimated 39%) psychiatrists returned the completed questionnaire. The qualitative analysis of free‐text data has shown variation within services in the experience and views of the psychiatrists. In areas with good support for STOMP implementation provided through adequate resources, psychiatrists reported satisfaction in the process with successful antipsychotic rationalisation, better local multi‐disciplinary and multi‐agency working, and increased awareness of STOMP issues among the stakeholders such as people with intellectual disabilities and their caregivers and multidisciplinary teams, and improved quality of life caused by reduced medication‐related adverse events in people with intellectual disabilities. However, where resource utilisation is not optimum, psychiatrists seemed dissatisfied with the process with little success in medication rationalisation.ConclusionsWhereas some psychiatrists are successful and enthusiastic about rationalising antipsychotics, others still face barriers and challenges. Much work is needed to achieve a uniformly positive outcome throughout the United Kingdom.
The range of uses of virtual reality for intensive care unit staff training: A narrative synthesis scoping review
Authors: Hill James , Hamer Oliver , Breed Hetty , Ford Jordan , Twamley Jacqueline , Kenyon Roger , Twamley Huw , Casey Rob , Zhang Jennifer , Clegg Andrew 
Published: February 2023

AbstractBackgroundThe use of virtual reality (VR) in medical education allows learners to make mistakes safely without risk to patients and to refine a range of clinical skills by repetition. However, there is still wide variability both between, and within countries regarding the amount of training delivered using VR, particularly in relation to intensive care medicineObjectivesTo identify the range of uses, phase of development and effectiveness of VR for intensive care unit (ICU) staff training.MethodsThe review followed the scoping review framework set out by Levac et al. (2010). A multi‐database search was undertaken. All study types were included if they explored the use of VR for intensive care staff (ICU) staff training. Full paper screening, data extraction and assessment of bias was carried out by a single reviewer with verification by a second reviewer. A narrative synthesis was chosen to summarize the data.ResultsThe search strategy identified 647 records. Following the removal of duplicates, screening of titles, abstracts and full texts, five studies were included. VR for ICU training has primarily focused on skill acquisition for surgical procedures. The majority of studies in this area were classified to be at an early stage of assessing acceptability, tolerability and efficacy. There was very low‐quality evidence that VR for ICU training is effective.ConclusionsStudies have explored the use of VR for a small number of surgical procedures and emergency patient scenarios. VR for ICU training demonstrates some potential, however further development and high‐quality research is required. Research relating to virtual reality for ICU staff training is currently of weak methodological quality and as such, no recommendations to clinical practise can be made. Wherever possible when using VR for ICU staff training it should be utilized as part of a high‐quality study.
Primordial and primary prevention of peri‐implant diseases: A systematic review and meta‐analysis
Authors: Carra Maria Clotilde , Blanc‐Sylvestre Nicolas , Courtet Alexandre , Bouchard Philippe 
Published: February 2023

AbstractAimThis systematic review and meta‐analysis aims to assess the efficacy of risk factor control to prevent the occurrence of peri‐implant diseases (PIDs) in adult patients awaiting dental implant rehabilitation (primordial prevention) or in patients with dental implants surrounded by healthy peri‐implant tissues (primary prevention).Materials and MethodsA literature search was performed without any time limit on different databases up to August 2022. Interventional and observational studies with at least 6 months of follow‐up were considered. The occurrence of peri‐implant mucositis and/or peri‐implantitis was the primary outcome. Pooled data analyses were performed using random effect models according to the type of risk factor and outcome.ResultsOverall, 48 studies were selected. None assessed the efficacy of primordial preventive interventions for PIDs. Indirect evidence on the primary prevention of PID indicated that diabetic patients with dental implants and good glycaemic control have a significantly lower risk of peri‐implantitis (odds ratio [OR] = 0.16; 95% confidence interval [CI]: 0.03–0.96; I2: 0%), and lower marginal bone level (MBL) changes (OR = –0.36 mm; 95% CI: −0.65 to −0.07; I2: 95%) compared to diabetic patients with poor glycaemic control. Patients attending supportive periodontal/peri‐implant care (SPC) regularly have a lower risk of overall PIDs (OR = 0.42; 95% CI: 0.24–0.75; I2: 57%) and peri‐implantitis compared to irregular attendees. The risk of dental implant failure (OR = 3.76; 95% CI: 1.50–9.45; I2: 0%) appears to be greater under irregular or no SPC than regular SPC. Implants sites with augmented peri‐implant keratinized mucosa (PIKM) show lower peri‐implant inflammation (SMD = –1.18; 95% CI: −1.85 to −0.51; I2: 69%) and lower MBL changes (MD = –0.25; 95% CI: −0.45 to −0.05; I2: 62%) compared to dental implants with PIKM deficiency. Studies on smoking cessation and oral hygiene behaviors were inconclusive.ConclusionsWithin the limitations of available evidence, the present findings indicate that in patients with diabetes, glycaemic control should be promoted to avoid peri‐implantitis development. The primary prevention of peri‐implantitis should involve regular SPC. PIKM augmentation procedures, where a PIKM deficiency exists, may favour the control of peri‐implant inflammation and the stability of MBL. Further studies are needed to assess the impact of smoking cessation and oral hygiene behaviours, as well as the implementation of standardized primordial and primary prevention protocols for PIDs.