bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the Efficiency of the Individual Case Safety Report (ICSR)
Quality and Compliance through Automation
Authors: Link Shannon , Kammler Adam , Gupta Ritu , Hembade Mahendra , Kumar Retesh , George Vinu 
Published: August 2023

Background:
Over the past few years, major inspection findings have been identified in
the “management of adverse reactions” that may be due to increasing workload in pharmaceutical
organizations impacting the correctness of information in individual case safety reports (ICSRs).
Although retrospective quality check (Retro-QC) and late submission analyses are important steps
in ensuring ICSR quality, their manual application poses several challenges that can be overcome
through automation.

Objective:
To improve the efficiency of the Retro-QC analysis and late submission analysis using a
computer-operated tool called Compliance and Metrics Management (CMM) tool, and to measure
the tool’s effectiveness in terms of productivity, time, and cost savings by comparing against the
manual process.

Methods:
Time savings were calculated by measuring the difference in time taken during the manual
process versus the automated process. Cost savings were measured in terms of hourly remuneration
for the time saved. Productivity was calculated as the difference between the number of cases
handled in the manual versus automated process. Thus, the overall efficiency was measured in
terms of time and cost savings along with increased productivity.

Results:
Automation resulted in time savings of 49% and cost savings of 43% for Retro-QC analysis,
and the productivity level increased by 67%. For late submission analysis, the CMM tool
resulted in time savings of 88% and cost savings of 87%.

Conclusion:
CMM tool enhanced the efficiency of both Retro-QC and late submission analyses by
increasing productivity along with time and cost savings. It also reduced the number of errors,
thereby enhancing the accuracy of the process and overall compliance.
Autophagy Behavior under Local Hypothermia in Myocardiocytes Injury
Authors: Abdullah Marzoog Basheer 
Published: August 2023

Abstract:
Hypothermia and autophagy are critical regulators of cell homeostasis by regulating
intra and intercellular cell communication. Myocardiocyte cryotherapy poses multiple cellular and
subcellular effects on the injured cell, including upregulation of autophagy. Autophagy plays a
crucial role in modifying cell metabolism by regulating downregulation, reducing reactive oxygen
species production, and improving the natural cellular antioxidant defense system. Reduction of
reactive oxygen species production and improving natural cellular antioxidant defense system.
Therapeutic hypothermia ranges from 32-34°C in terms of local myocardiocyte cooling. Hypothermia
induces autophagy by phosphorylating the Akt signaling pathway. Hypothermia has a
more therapeutic effect when applied at the beginning of reperfusion rather than in the beginning
of ischemia. Moderate hypothermia with 33°C poses most therapeutic effect by viability maintaining
and reduction of reactive oxygen species release. Application of local hypothermia to myocardiocytes
can be applied to infarcted myocardiocytes, anginal and to the cardiomyopathies.
Hepatic Ischemia-reperfusion Injury: Protective Approaches and Treatment
Authors: Singh Kuldeep , Gupta Jeetendra Kumar , Kumar Shivendra , Anurag  , Mukherjee Soumyadip , Patel Aman 
Published: August 2023

Abstract:
Ischemia and reperfusion damage to the liver is one of the major causes of hepatic dysfunction and liver failure after a liver transplant. The start of hepatic ischemia-reperfusion damage is linked to metabolic acidosis, Kupffer cells, neutrophils, excessive calcium, and changes in the permeability of the mitochondrial membrane. Hypoxia activates Kupffer cells, resulting in the production of reactive oxygen species (ROS). These ROS when accumulated, causes apoptosis and necrosis, as well as activate immune and inflammatory responses that involve many cells and signalling molecules. Numerous antioxidant compounds have been researched to lessen oxidative stress and thus serve as potential compounds to deal the ischemia-reperfusion damage. This article confers a deep understanding of the protective effects of some effective therapies, including hepatoprotective agents, attenuation of an increase in xanthine oxidase activity, and administration of antioxidants like N-acetylcysteine, superoxide dismutase (SOD), and ornithine.
Are Adolescents Engaged in Violent Radicalization Suicidal?
Authors: Dao Valerie , Oppetit Alice , Pellerin Hugues , Chamboredon Elsa , Aouidad Aveline , Bronsard Guillaume , Campelo Nicolas , Cohen David 
Published: August 2023

Introduction:
Radicalization among adolescents is a rising phenomenon that has
become a public health concern in Europe. According to some authors, violent radicalization by
resorting to self-violence could be a form of suicidal behavior. However, evidence-based studies to
support this assertion are lacking.

Objective:
The aim of this study was to investigate the issue of suicidality among adolescents
engaged in violent radicalization.

Methods:
We compared a group of radicalized adolescents convicted of criminal association to
commit terrorism (AMT) in France (N=15) with hospitalized adolescents who have attempted to
end their lives (N=320). This comparative study is based on two samples from two studies that used
the same instruments to assess psychiatric diagnoses, suicide risk, reasons for living, and coping.

Results:
AMT adolescents were significantly less suicidal and less depressive/ hopeless than
adolescents with suicide attempts (SAs). AMT adolescents showed fewer instances of depressive
and borderline personality disorders but more manic and psychotic episodes than SA adolescents.
They also had much more efficient coping strategies than SA adolescents, especially for the
following strategies: seeking professional help, relational support and spiritual support. All the
subscores of the reasons for the living scale were significantly higher for AMT adolescents than for
SA individuals, apart from the subscore on peer acceptance and support.

Conclusion:
Adolescents engaged in violent radicalization cannot be considered suicidal
adolescents who have found an opportunity to end their lives through the process of radicalization.
Understanding this phenomenon within a social, political and cultural context is necessary.
En el desafío de la predicción de la respuesta a terremotos mediante el enfoque de redes neuronales
Authors: Zavala Toledo Carlos , Diaz Miguel , Honma Claudia 
Published: August 2023

Since the decade of the 1990 the neural networks algorithms have been used for compute approximate solutions for different problems in engineering.
In the building behavior against loads is important to know its response. The behavior during the earthquakes and the estimation of the response is quite difficult to compute due to the nonlinearity of geometry and material properties. Neural networks approach is a powerful tool for computing the response of structures with an appropriate learning process from big data of structural components. Even if some material parameters are unknown, the learning on a neural network will be possible and will provide an estimation using collect information from experience and learning.
To make a learning process in this paper, we present a simple algorithm of back propagation implemented in python programming language where the output shows the decrease of the error and how the response start to learn from the beginning until the end of the process. The results show good agreement between the learning data set and predicted response after the neural network learning.
Managing the Development of Integration Processes in the Innovation Environment of the Region
Authors: Nikitin S. A. , Tronina I. A. , Tatenko G. I. , Grekova A. E. 
Published: August 2023

Relevance. Integration processes form the modern image of the innovative model of the economy through the successful functioning and competent interrelation of the structural elements of the innovation system at the national and regional levels. The control levers of such systems should be effective, and therefore sufficiently diverse and flexible, so as not to limit the system, but to ensure the processes of its functioning and development in the conditions of the singularity of the external environment. A new approach to the study of the problems of innovative development of the region can be offered by the theory of systems with an emphasis on a new understanding of complex self-organizing structures, as well as the concept of open innovation, which allows participants in the innovation process to establish partnerships based on knowledge exchange.The purpose of the study is to find a model solution to the problem of managing the development of integration processes in the innovation environment of the region.The objectives of the study can be formulated as follows: identification of problems of innovative development of the territory; study of theoretical constructions of the development of integration processes in the innovation environment of the region; theoretical justification and development of a model solution for the formation of interaction of stakeholders of the innovation process based on the model of the «Quadruple Innovation Helix».Methodology. The research methodology consists of general scientific methods of cognition, statistical methods, as well as principles and methods of a systematic approach.Results. One of the important problems of the innovative development of the territory is the low level of integration processes that ensure the interaction of regional stakeholders. A model solution to the problem of managing the development of integration processes based on the principles of managing a region as a complex dynamic system and an open innovation model is proposed. This model reveals the problem of balancing the innovative development of the region from the perspective of taking into account the interests of participants in the innovation process.Conclusions. The use of the proposed model allows a comprehensive and systematic approach to the study of the possibilities of effective interaction of participants in the innovation process in the region with the observance of the conditions of balance and synergy as a result for the evaluation of the integration process.
Staffing in the Hospitality Industry of the Kursk Region: Finding a Solution to the Problem
Authors: Abushenkova M. V. 
Published: August 2023

Relevance. The relevance of the study is determined by the rapid development of domestic tourism, which revealed the most important problem of the industry - the shortage of professional personnel. In order not to lose the growing interest of travelers in new areas of domestic tourism, it is necessary to improve the skills of employees of the hospitality industry as soon as possible and more effectively.The purpose of this study is to find a solution to the problem of staffing, which will ensure the quality of customer service of the hospitality industry in the Kursk region.Objectives: assessment of the dynamics of employment in the hospitality sector in the country and in the Kursk region; investigation of the causes of professional staff turnover; search for ways out of the crisis situation; development of proposals aimed at solving the problem of staffing in the hospitality industry of the Kursk region.Methodology. Within the framework of the study, materials of news agencies, standard methods of statistical processing were used; methods of scientific generalization, collection and processing of information, as well as methods of comparative and strategic analysis were applied.Results. The results of the study showed that the problem of staffing the hospitality industry in the Kursk region remains relevant and requires close attention. To solve it, it is necessary to combine the efforts of organizations of higher, secondary and additional education with the needs of employers in the hospitality industry.Conclusions. The dynamic and sustainable functioning and development of the hospitality industry requires solving the problem of staffing, including due to the high level of turnover of specialists. Educational organizations of different levels and professional associations do not ignore the emerging challenges and discuss the development of training programs for specialists in this field of activity.
Prospects for Trade Cooperation between Russian Regions and the Countries of the African Continental Free Trade Area (on the Example of the Kursk Region)
Authors: Khaustova T. V. , Soklakov A. A. 
Published: August 2023

Relevance.In modern conditions, in the interaction of Russia with foreign partners, there are trends towards changing traditional global value chains and changing logistics directions. In this connection, Russia needs to address the issue of expanding trade cooperation with new partners and the formation of more sustainable value chains.The purposeis identifying and evaluating the main foreign trade indicators that affect the cooperation of Russia and its regions with the countries of the African Continental Free Trade Area.Objectives:to analyze the volume and structure of Russia's foreign trade turnover with the countries of the African Continental Free Trade Area; determine the conditions that can contribute to the expansion of Russia's partnership with the countries of the African Continental Free Trade Area; to propose directions for the development of foreign trade relations between the regions of Russia and the countries of the African Continental Free Trade Zone (on the example of the Kursk region).Methodology.The study is based on the statistical collection and analysis of information on the volume, structure and dynamics of foreign trade with the countries of the African Continental Free Trade Area.Results.The analysis of the main indicators characterizing the mutual foreign trade of Russia and its regions with the countries of the African Continental Free Trade Area has been carried out. The main trading partners among African countries and the conditions for expanding partnerships with them have been identified.Conclusions.It is concluded that the countries of the African continental free trade zone are the main market for certain types of domestic agricultural products of the extractive and manufacturing industries, and Russian enterprises receive the raw materials they need from African countries. At the same time, the expansion of Russia's trade relations with African countries will be facilitated by the conclusion of agreements on the creation of free trade zones, primarily with Egypt, as the main trading partner.
Omnichannel Approach to Customer Service in the Digital Economy
Authors: Kazarenkova N. P. , Biktagirova E. V. , Ershov N. Yu. 
Published: August 2023

Relevance. The current conditions for the development of the customer service system in companies of various business profiles are characterized by the influence of many factors: from uncertainty and increased risks against the background of the consequences of the coronavirus pandemic and sanctions pressure to the digital transformation of business processes. At the same time, generations of potential consumers are changing, which contributes to the transformation of approaches to customer service and their requirements for the quality of products, services and services.In this regard, the relevance of finding new customer service channels, expanding the sphere of promotion of products and services to potential consumers, as well as mastering new methods and technologies of client services is growing. The implementation of these areas is possible on the basis of the development and implementation of an omnichannel service system for a potential and formed client base.The purposeof the study is to identify modern trends and potential for the development of an omnichannel approach to customer service in the context of the digital transformation of the Russian economy.Objectives: highlight the factors of changing the paradigm of customer service; determine the directions of transformation of customer service services; identify the prerequisites for using the omnichannel approach to the implementation of client services and the potential for its development in the modern conditions of the digital economy.Methodology. In the course of the study, general scientific methods were used: scientific abstraction, analysis and synthesis, generalization and extrapolation.Results. The study made it possible to form and highlight the following scientific results: the essence and content of the omnichannel approach to customer service was determined; the classification of channels and customer service services in the aggregate of the omnichannel approach was given, promising directions of omnichannel service systems in the digital economy were identified.Conclusions. The digital transformation of business processes affects the customer service system, primarily in terms of the choice of specific channels and services, as well as an integrated approach to their implementation. Customer focus as a basic trend in the development of modern business contributes to improving the efficiency of the customer service system based on omnichannel services.
The Impact of Tax Benefits and Preferences on the Territorial Development of Russia: a Regional Aspect
Authors: Belousova S. N. , Tatyana T. Yu. 
Published: August 2023

Relevance. The formation of a rational spatial organization of the economy of the country and its regions is the most important function of any state, associated with its self-preservation and sustainable socio-economic development. As tools to stimulate territorial development, the state uses tax and customs benefits and preferences, creates more comfortable conditions for the development and operation of business in certain areas of the country.The introduction of various tax incentives is an effective tool for ensuring the development of the economy and society, however, like most economic categories, tax preferences have a dual nature: if the existence of a tax expense is inefficient, then this reduces the overall well-being due to the appearance of falling budget revenues.Purpose. The main purpose of the work is to evaluate the effectiveness of preferential taxation as a tool for socio-economic stimulation of the country's territories.It is concluded that the established tax and customs benefits in the special territories of the Russian Federation contribute to the growth in the production of goods and services, the growth of investments, the increase in the number of jobs, but at the same time create tax risks.Objectives. The following tasks are solved in the article: measures of tax and customs support for territories with a special status in the Russian Federation are reflected; the performance of the SEZ for 2017-2021 was assessed; tax expenses incurred.Methodology. The methodological base of the study is based on a set of methods of economic research, united by a systematic approach to the study of this problem.Results. The article presents the results of assessing the impact of tax benefits and preferences on the socioeconomic development of special territories of Russia, and identifies the most significant risks for the state from the consequences of preferential taxation.Conclusions. Tax incentives must be considered as the tax costs incurred by the state and possible tax risks. In order to reduce tax risks, in our opinion, it is necessary to establish tighter control by the state over the amounts released as a result of the provision of tax benefits and preferences.
Determinants of the Development of the Regional Market for the Sale of Dairy Products in Large Retail Chains
Authors: Polozhentseva Yu. S. , Logvinov I. O. 
Published: August 2023

Relevance. An analysis of the regional market for the sale of dairy products in large retail chains will make it possible to identify the main players in the market, their shares and strategies, as well as to identify the characteristics of consumer demand and supply in this category of products.The purposeis to conduct a comprehensive study of the regional market for dairy products in large retail chains in order to determine the determinants of development and the main players in the market, their shares and strategies, as well as the size of the share of each manufacturer in this market.Objectives: collect and analyze data on sales of dairy products in large retail chains in the region; identify the main players in the market, their shares and strategies; based on the results obtained, to draw conclusions and determine the determinants of development to improve the position of manufacturers and retailers in the dairy market in the city of Kursk.Methodology.In the course of the study, general scientific methods of logical and statistical analysis, as well as qualitative and quantitative analysis, were used.Results.The share of producers of the Kursk region of the total number of dairy producers represented in the retail chains of the city of Kursk is 17,13%, of which 7,69% is occupied by the production of the city of Kursk. The volume of dairy products sold in large retail chains in the city of Kursk for 2022 for five positions decreased by an average of 20,5%.Conclusions.There is a small amount of imports of goods from local producers to large retail chains of the city, which may indicate a lack of support and priority for the city to work with local producers in these networks. It may also indicate possible limitations in the production capacity of local producers, their lack of competitiveness in comparison with other producers from other regions.