bluuebunny/crossref_metadata_2025_split huggingface dataset:
GOLD grade-specific characterization of COPD in the COSYCONET multi-center trial: comparison of semiquantitative MRI and quantitative CT
Authors: Konietzke Philip , Weinheimer Oliver , Triphan Simon M. F. , Nauck Sebastian , Wuennemann Felix , Konietzke Marilisa , Jobst Bertram J. , Jörres Rudolf A. , Vogelmeier Claus F. , Heussel Claus P. , Kauczor Hans-Ulrich , Wielpütz Mark O. , Biederer Jürgen ,   on behalf of the COSYCONET study group
Published: January 2025

Abstract
Objectives
We hypothesized that semiquantitative visual scoring of lung MRI is suitable for GOLD-grade specific characterization of parenchymal and airway disease in COPD and that MRI scores correlate with quantitative CT (QCT) and pulmonary function test (PFT) parameters.

Methods
Five hundred ninety-eight subjects from the COSYCONET study (median age = 67 (60–72)) at risk for COPD or with GOLD1-4 underwent PFT, same-day paired inspiratory/expiratory CT, and structural and contrast-enhanced MRI. QCT assessed total lung volume (TLV), emphysema, and air trapping by parametric response mapping (PRMEmph, PRMfSAD) and airway disease by wall percentage (WP). MRI was analyzed using a semiquantitative visual scoring system for parenchymal defects, perfusion defects, and airway abnormalities. Descriptive statistics, Spearman correlations, and ANOVA analyses were performed.

Results
TLV, PRMEmph, and MRI scores for parenchymal and perfusion defects were all higher with each GOLD grade, reflecting the extension of emphysema (all p < 0.001). Airway analysis showed the same trends with higher WP and higher MRI large airway disease scores in GOLD3 and lower WP and MRI scores in GOLD4 (p = 0.236 and p < 0.001). Regional heterogeneity was less evident on MRI, while PRMEmph and MRI perfusion defect scores were higher in the upper lobes, and WP and MRI large airway disease scores were higher in the lower lobes. MRI parenchymal and perfusion scores correlated moderately with PRMEmph (r = 0.61 and r = 0.60) and moderately with FEV1/FVC (r = −0.56).

Conclusion
Multi-center semiquantitative MRI assessments of parenchymal and airway disease in COPD matched GOLD grade-specific imaging features on QCT and detected regional disease heterogeneity. MRI parenchymal disease scores were correlated with QCT and lung function parameters.

Key Points
QuestionDo MRI-based scores correlate with QCT and PFT parameters for GOLD-grade specific disease characterization of COPD?
FindingsMRI can visualize the parenchymal and airway disease features of COPD.
Clinical relevanceLung MRI is suitable for GOLD-grade specific disease characterization of COPD and may serve as a radiation-free imaging modality in scientific and clinical settings, given careful consideration of its potential and limitations.
The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial
Authors: Kregting Lindy , van den Oever Daan , Pennings Lian , Pijnappel Ruud , van Ravesteyn Nicolien , Verschuur Ellen , van Oirsouw Marja , Dunning Loes , ‘t Mannetje Hans , van Engen Ruben , Bluekens Adriana , Smid-Geirnaerdt Maartje , van Landsveld-Verhoeven Cary , Houssami Nehmat , Sechopoulos Ioannis , Broeders Mireille 
Published: January 2025

Abstract
Objectives
It is uncertain what the effects of introducing digital breast tomosynthesis (DBT) in the Dutch breast cancer screening programme would be on detection, recall, and interval cancers (ICs), while reading times are expected to increase. Therefore, an investigation into the efficiency and cost-effectiveness of DBT screening while optimising reading is required.

Materials and methods
The Screening Tomosynthesis trial with advanced REAding Methods (STREAM) aims to include 17,275 women (age 50–72 years) eligible for breast cancer screening in the Netherlands for two biennial DBT screening rounds to determine the short-, medium-, and long-term effects and acceptability of DBT screening and identify an optimised strategy for reading DBT. The control group will consist of 86,400 women selected from the database of the Dutch breast cancer screening programme screened with digital mammography. The intervention group will undergo DBT examinations only. Four different reading strategies will be evaluated on a subset of first-round screening exams. These four strategies will also be evaluated combined with replacing one of the two readers with AI predictions. The Microsimulation Screening Analysis (MISCAN)-Breast model will be used to estimate the long-term outcomes of DBT screening assuming the best-performing reading method.

Results
The primary outcome measure is the IC and advanced cancer rate at the second round (combined endpoint) in the DBT group compared to the control group. Secondary outcome measures are participation, recall and detection rates, positive predictive value, acceptability, reading method with the best case-based area under the curve and reading time, predicted breast cancer mortality, number of cancers overdiagnosed, and cost-effectiveness.

Key Points
Question The short-, medium-, and long-term effects of digital breast tomosynthesis (DBT) imaging in the Dutch breast cancer screening programme are unknown, but essential to decide about implementation.
Findings This protocol paper describes the primary endpoint of the STREAM trial: the combined interval and advanced cancer detection rate at the second DBT round.
Clinical relevance The STREAM trial is a prospective, non-randomised, population-based study in the Dutch breast cancer screening programme, that aims to evaluate the effects and acceptability of two rounds of DBT screening to determine if DBT can enhance the programme’s outcomes.

Graphical Abstract
The tumor distance to the main hepatic vessels is a predictor of recurrence-free survival and overall survival in hepatocellular cancer
Authors: Abdelhadi Schaima , Rink Johann S. , Froelich Matthias F. , Șandra-Petrescu Flavius , El-Ahmar Mohamad , Oweira Hani , Rahbari Nuh N. , Reissfelder Christoph , Birgin Emrullah 
Published: January 2025

Abstract
Introduction
The impact of the distance of the tumor from the main hepatic vessels (DTV), such as the Glissonean pedicle or hepatic veins, on oncological outcomes for Hepatocellular carcinoma (HCC) patients is relatively understudied. Therefore, the objective of this study was to explore the correlation between DTV and survival in patients with HCC after curative hepatic resection.

Methods
Consecutive patients who underwent curative-intent liver surgery for HCC between April 2018 and May 2023 were identified from a prospective database. Univariate and multivariate Cox regression analysis were performed to identify independent predictors of recurrence-free survival (RFS). A ROC-curve was used to find the optimal cut-off value for DTV. According to the estimated cut-off value, patients were divided into 2 subgroups, then using the Kaplan-Meier survival curve, RFS and overall survival (OS) were estimated and compared between the 2 subgroups.

Results
In univariate analysis, DTV, tumor size, resection margins, microvascular invasion (MVI) and tumor grading were associated with RFS. In multivariate analysis, DTV, tumor size, and MVI were confirmed as independent predictors of RFS. In the ROC-analysis the optimal cutoff value of DTV was 20 mm. Patients with a DTV < 20 mm had a larger tumor size and a more advanced histopathological grading. There was no difference in the presence of MVI in both groups, while a significantly more patients experienced recurrence after hepatectomy in the DTV < 20 mm group. Accordingly, patients with a DTV < 20 mm experienced a shorter median RFS and OS.

Conclusion
DTV is a promising predictor of RFS and OS in HCC.
Revolutionizing online shopping with FITMI: a realistic virtual try-on solution
Authors: Samy Tassneam M. , Asham Beshoy I. , Slim Salwa O. , Abohany Amr A. 
Published: January 2025

AbstractIn today’s digital age, consumers increasingly rely on online shopping for convenience and accessibility. However, a significant drawback of online shopping is the inability to physically try on clothing before purchasing. This limitation often leads to uncertainty regarding fit and style, resulting in customer post-purchase dissatisfaction and higher return rates. Research indicates that online items are three times more likely to be returned than in-store ones, especially during the pandemic. To address this challenge, we propose a virtual try-on method called FITMI, an enhanced Latent Diffusion Textual Inversion model for virtual try-on purposes. The proposed architecture aims to bridge the gap between traditional in-store try-ons and online shopping by offering users a realistic and interactive virtual try-on experience. Although virtual try-on solutions already exist, recent advancements in artificial intelligence have significantly enhanced their capabilities, enabling more sophisticated and realistic virtual try-on experiences than ever before. Building on these advancements, FITMI surpasses ordinary virtual try-ons relying on generative adversarial networks, often producing unrealistic outputs. Instead, FITMI utilizes latent diffusion models to generate high-quality images with detailed textures. As a web application, FITMI facilitates virtual try-ons by seamlessly integrating images of users with garments from catalogs, providing a true-to-life representation of how the items would look. This approach differentiates us from competitors. FITMI is validated using two widely recognized benchmarks: the Dress-Code and Viton-HD datasets. Additionally, FITMI acts as a trusted style advisor, enhancing the shopping experience by recommending complementary items to elevate the chosen garment and suggesting similar options based on user preferences.
On covering radii in function fields
Authors: Soffer Aranov Noy 
Published: January 2025

AbstractIn this paper, we shall discuss topics in geometry of numbers in the function field setting, such as covering radii. We find a closed form for covering radii with respect to convex bodies, which will lead to a proof of the function field analogue of Woods’ conjecture in this setting. Then, we will prove a function field analogue of Minkowski’s conjecture about the multiplicative covering radius. To do this, we shall prove a function field analogue of Solan’s result that every diagonal orbit intersects the set of well rounded lattices. This implies that the Gruber–Mordell spectrum in function field is trivial in every dimension.
Digital 3D exoscope is an effective tool for the surgery of falx and parasagittal meningiomas
Authors: Vasankari Ville , Garcia Sergio , Baric Hrvoje , Niemelä Mika , Lehecka Martin 
Published: January 2025

Abstract
Purpose
Digital 3D exoscopes are promising tools for microneurosurgery. The results of exoscope-assisted resection of intracranial meningiomas have only been addressed in few case reports. We retrospectively compared the results of exoscope and microscope-assisted surgery of falx and parasagittal meningiomas.

Methods
We included all consecutive adult patients (n = 36) with falx or parasagittal meningioma who were operated with curative intention during an 8-year period by one senior neurosurgeon. The operations were performed either with a surgical microscope (n = 16; Zeiss Kinevo or Pentero 900) or a digital 3D exoscope (n = 20, Aesculap Aeos). We reviewed the pre- and postoperative radiological images, clinical examinations and surgical reports to assess clinical outcomes and complications. We also analyzed surgical videos.

Results
Gross-total resection (Simpson grade I-II) was achieved in approximately 90% of the patients in both groups (89% in exoscope and 92% in microscope group). The duration of the operation was slightly longer (117 vs. 88 min) in the exoscope group. Surgical outcomes were comparable, despite there being larger tumors (median diameter 53 vs. 38 mm) with higher grades (WHO Grade 2–3: 45% vs. 19%) in the exoscope group. Transient postoperative complications were more frequent in the exoscope group (40 vs. 25%) mainly related to the larger tumor size.

Conclusion
The digital 3D exoscope is an effective tool for performing surgery on falx and parasagittal meningiomas. The extent of removal, clinical results and complications seem to be comparable to surgical microscope even in large tumors. Larger prospective studies are required to confirm this result.
Digital twin and the asset administration shell
Authors: Zhang Jingxi , Ellwein Carsten , Heithoff Malte , Michael Judith , Wortmann Andreas 
Published: January 2025

AbstractEngineering digital twins is a software and systems engineering challenge for which no systematic approach exists. The Asset Administration Shell is becoming a popular foundation for digital twins in Industry 4.0 and it comes in different types that support the engineering of different kinds and parts of digital twins. We investigate how it supports realizing common requirements for digital twins. To this end, we investigate how each of the three Asset Administration Shell types can contribute to the systematic engineering of specific components of digital twins. Therefore, we analyzed popular definitions and conceptual models of digital twins and extracted requirements that at least two of them share. We compare the resulting requirements with Asset Administration Shells of different types and conclude with open challenges in the implementation of digital twins with this technology. This supports practitioners and researchers in identifying the most suitable type of Asset Administration Shell for their specific digital twin engineering needs and identifies gaps worthy of future research toward a systematic engineering of digital twins.
Seasonal patterns in sediment nitrification rates and their linkages to ammonium cycling in three agricultural streams
Authors: Vincent Anna E. S. , Tank Jennifer L. , Mahl Ursula H. 
Published: January 2025

AbstractNitrification, or the microbial transformation of ammonium (NH4+–N) to nitrate, is influenced by NH4+–N and dissolved oxygen availability, water temperature, and carbon-to-nitrogen ratios. Open-canopy agricultural streams receive excess inorganic nitrogen (N) from the surrounding landscape and the mineralization of organic-rich sediments, and the form and timing of these N inputs varies throughout the year. Compared to forested streams, the seasonality of nitrification rates in agricultural streams are not well documented. We conducted nitrification assays on stream sediments to estimate seasonal rates in three agricultural streams from summer 2020 to spring 2021. We documented seasonal variation in nitrification rates and identified changes in environmental controls [e.g., stream temperature, NH4+–N and dissolved organic carbon (DOC) availability, chlorophyll-a]. Nitrification rates were highest in spring (54.4 ± 12.7 mg N m−2 d−1; p = 0.02), coinciding with elevated NH4+–N and higher stream temperatures relative to winter (p < 0.001). Rates were lowest in autumn (19.9 ± 3.5 mg N m−2 d−1) when organic carbon concentrations peaked (17.2 ± 10.3 mg C L−1; p = 0.01). Algal senescence in autumn may allow heterotrophs to outcompete nitrifiers for NH4+–N. However, partial least square regression analyses indicated that sediment organic matter (as %OM) is an important positive predictor of nitrification, suggesting carbon can be an indirect positive control on nitrification. In the context of previous studies, agricultural streams had elevated NH4+–N concentrations, but nitrification rates were comparable to those in less impacted systems. Although complex interactions exist among rates and drivers, rates from this study help expand documentation of nitrification in agricultural streams, and provide insight into temporal variation and dominant controls.
The effect of exploiting the public good on climate cooperation: evidence from a collective-social risk dilemma experiment
Authors: Cloos Janis , Greiff Matthias , Kempa Karol 
Published: January 2025

AbstractReaching ambitious climate targets is challenging, due the individual incentives of countries to free ride and to continue contributing to climate change. This issue of climate change has been analyzed in collective-risk social dilemma (CRSD) experiments, where participants interact in groups and can invest money in a group account over a fixed number of rounds. If the group account is below a threshold after the last round, the group members lose a large proportion of their assets. In the real world, however, agents can not only invest in public goods, but also exploit them. We argue that this possibility reduces the likelihood to reach the threshold. To test this prediction, we introduce the option to also exploit the public good in a CRSD experiment. The results reveal that a take option negatively affects the likelihood of reaching the threshold. Overall, the effect of the existence of a take option is rather small and not statistically significant. However, if participants exert their option to exploit the public good at the beginning, the success rate drops significantly. Consistent with the results of previous studies without the option of exploiting the public good, we find that a lower loss rate makes cooperation less likely, but the effect of heterogeneity is less clear. Our findings indicate that CRSD experiments that do not consider exploitation are likely to overestimate the likelihood of successful cooperation. The key implication for policy is to focus on reducing the incentives of the take option.
A cyber-physical architecture to monitor human-centric reconfigurable manufacturing systems
Authors: Sbaragli Andrea , Ghafoorpoor Poorya Yazdi , Thiede Sebastian , Pilati Francesco 
Published: January 2025

AbstractReconfigurable manufacturing systems represent the most adequate production paradigm due to their ability to meet mass customized needs while ensuring cost-effective flexibilities and performances. However, digital solutions are required to manage these dynamic environments over working shifts and processes’ reconfiguration. In this scenario, this work proposes a layout and task-insensitive cyber-physical architecture to monitor human-centric reconfigurable manufacturing systems. Workers’ motion patterns and industrial resources’ positions are acquired through a radio-frequency-based real-time locating system. These data streams are fed into a machine-learning cyber layer to segment operators’ activities during production cycles into two steps. The first computational stream assigns workers’ motion patterns to industrial resources regardless of the system configuration. The following step distinguishes workers’ operations into value-added and non-value-added. These outputs are stored in a decision support system where customized callback functions develop key performing indicators to monitor the performance of such reconfigurable human-centric environments. The validity of the cyber-physical architecture is demonstrated in an industrial-related pilot environment, involving 40 workers and 8 production set-ups.
On the resiliency of post-crisis decoupling in higher-order economy-energy-environment nexus in high-inflation developing economies
Authors: Basu Soumya , Ishihara Keiichi 
Published: January 2025

AbstractMacroeconomic pathways of enabling decoupling of emissions from economic growth in a post-crisis period is analyzed in this study for the high-inflation developing economy of India. A novel control system internalizing the inherent stochasticity of economy-energy-environment (3E) nexus extends the interpretation of Environmental Kuznets Curve hypothesis, where this study finds that decoupling is an emergent phenomenon of a 3E system. Using Zivot-Andrews unit root test, adaptive error correction modelling and robustness analysis through information theory-based approximate entropy method, the stochastic model is found to reproduce real-world higher order phenomena more accurately than previously theorized systems. With high entropy (information content) in long-run and short-run coefficients, the stochastic model can replicate the resiliency speed in a post-crisis period, without new information input. Some key findings of policy/macroeconomic linkages include: (a) decoupling progress lies in capital building and inhibited by inflationary growth; (b) fossil fuel imports, inflation and energy-use have a whiplash effect on carbon emissions in post-crisis periods; (c) electricity and non-electric-energy have differential effect on trade, with decoupling prevalent in electricity sector only; (d) inflation opposes GDP-emission causality during business cycle movements; (e) decoupling policies should be discretized to growth and recession phases of business cycle, with inflationary fossil fuel rebounds actively disincentivized in recession periods.
Wronging in believing
Authors: Crawford Lindsay 
Published: January 2025

AbstractWhat is it for a belief to wrong someone? Views that have largely shaped the recent literature on doxastic wronging maintain that beliefs that wrong do so in virtue of what is believed. This paper offers some criticisms of these views, as well as a contractualist alternative. On the view I defend here, beliefs can wrong when they stem from inferences licensed by principles to which others would have sufficiently weighty objections. Doxastic wronging, on this account, is not (or is not entirely) a matter of having beliefs with certain kinds of objectionable representational content, but rather a matter of our being unable to morally justify our beliefs to others.
LEA-RPL: lightweight energy-aware RPL protocol for internet of things based on particle swarm optimization
Authors: Mokrani Sabrina , Belkadi Malika , Sadoun Tassadit , Lloret Jaime , Aoudjit Rachida 
Published: January 2025

AbstractThis paper addresses the issue of quality of service routing optimization within the Internet of Things networks. We particularly focus on the energy-aware and the lightweight aspects. By recognizing the relationship between lightweight and energy-aware routing, we set out to study their combined benefits. This study aims to enhance the Routing Protocol for Low Power and Lossy Networks by integrating energy-awareness and lightweight characteristics based on the Particle Swarm Optimization algorithm. Our approach addresses energy consumption, routing overhead and decision complexity in route establishment. The principal contributions include the introduction of an objective function that considers Expected Life Time, Delay and a new proposed metric Energy Aware-Expected Transmission Count. The improvement of the Long Short Term Memory predicting inertia weight based PSO with Online Gradient Descent that is used to optimize both the parent selection process and Trickle Timer mechanism. The controlled parent switching process to solve unnecessary and frequent changes. Our approach is validated through simulations in Contiki COOJA, with thorough comparisons with some existing protocols based on packet delivery ratio, average energy consumption, convergence time, control overhead, average end-to-end delay and average parent switching as performance metrics. The results reveal that our approach performs better. Depending on the protocol used for comparison, our approach reduced parent switching by 42.59–61.73%, convergence time by 20.31–66.06%, control overhead by 14.4–23.64%, energy consumption by 29.86–49.6%, end-to-end delay by 7.66–40.81% and increased packet delivery ratio by 2–42.92%.