bluuebunny/crossref_metadata_2025_split huggingface dataset:
The magnitude and associated factors of immediate postpartum anemia among women who gave birth in east Gojjam zone hospitals, northwest- Ethiopia, 2020
Authors: Agmassie Getachew Altaseb , Alamneh Genet Degu , Ayicheh Moges Wubie , Getahun Worku Taye , Abneh Aysheshim Asnake 
Published: March 2023

BackgroundGlobally around half a million maternal death occurred annually related to labor and delivery of which twenty percent is contributed by post-partum anemia. Postpartum anemia contributes about two percent of total maternal mortality in Ethiopia. Immediate postpartum anemia is a common public health problem in most parts of the globe, being frequent in low and middle-income countries including in the developed world. The previous studies cut off point for immediate postpartum Anemia is 11mg/dl which is the cutoff point of anemia after one week of postpartum, environmental factors like barefoot were not addressed in the previous studies and the previous studies were conducted in a single facility This study aimed to assess the magnitude and associated factors of immediate post-partum anemia among women who gave birth in East Gojjam zone hospitals, Northwest Ethiopia.MethodsInstitutional based cross-sectional study was conducted from October 20-November 20 2020 on immediate post-partum anemia. During the study 467 study participants were included by using systematic random sampling method Data were collected using a structured interviewer-administered questionnaire and a blood sample was used for hemoglobin determination. Data were checked, coded, and entered into Epi-Data Version 4.2 and then exported to SPSS version 25 for analysis. Binary logistic regressions were done to identify predictors of immediate post-partum anemia and a 95% confidence interval of odds ratio at a p-value less than was taken as a significance level.ResultsThe overall magnitude of immediate postpartum anemia among mothers who gave birth in East Gojjam Zone Hospitals were found to be 21.63% (95% CI:18.12%, 25.11%), not having antenatal care follow-up (Adjusted Odds Ratio (AOR) = 2.92;95% CI:1.20,7.06), assisted instrumental delivery (AOR = 2.72; 95% CI:1.08,6.78),mid-upper arm circumferences less than 23cm (AOR = 5.75;95% CI:3.38, 9.79), antepartum hemorrhage (AOR = 4.51; 95% CI:2.42, 8.37), never wearing shoes (AOR = 2.60; 95% CI:1.10, 6.14) were found to be significantly associated with immediate postpartum anemia.ConclusionThis study indicates that immediate postpartum anemia is a moderate public health problem in the study area. A more careful strategy is ideal to increase antenatal care follow-up that sticks to national guideline contact schedule, safe reduction of instrumental and cesarean deliveries to the minimum, quick and timely linkage and treatment of malnourished pregnant mothers to the center where they get adequate health care services, along with a high index of suspicion in mothers diagnosed with antepartum hemorrhage, wise and vigilant advice on consistent use of the shoe for pregnant mothers are recommended to tackle the burden of immediate post-partum anemia.
Conceptual approaches in combating health inequity: A scoping review protocol
Authors: Amri Michelle , Mohamood Liban , Mansilla Cristián , Barrett Kathryn , Bump Jesse B. 
Published: March 2023

Introduction
What are the different ways in which health equity can be sought through policy and programs? Although there is a central focus on health equity in global and public health, we recognize that stakeholders can understand health equity as taking different approaches and that there is not a single conceptual approach. However, information on conceptual categories of actions to improve health equity and/or reduce health inequity is scarce. Therefore, this study asks the research question: “what conceptual approaches exist in striving for health equity and/or reducing health inequity?” with the aim of presenting a comprehensive overview of approaches.

Methods
A scoping review will be undertaken following the PRISMA guidelines for Scoping Reviews (PRISMA-ScR) and in consultation with a research librarian. Both the peer-reviewed and grey literatures will be searched using: Ovid MEDLINE, Scopus, PAIS Index (ProQuest), JSTOR, Canadian Public Documents Collection, the World Health Organization IRIS (Institutional Repository for Information Sharing), and supplemented by a Google Advanced Search. Screening will be conducted by two independent reviewers and data will be charted, coded, and narratively synthesized.

Discussion
We anticipate developing a foundational document compiling categories of approaches and discussing the nuances inherent in each conceptualization to promote clarified and united action.
“Stabilise-reduce, stabilise-reduce”: A survey of the common practices of deprescribing services and recommendations for future services
Authors: Cooper Ruth E. , Ashman Michael , Lomani Jo , Moncrieff Joanna , Guy Anne , Davies James , Morant Nicola , Horowitz Mark 
Published: March 2023

Background
Public Health England recently called for the establishment of services to help people to safely stop prescribed drugs associated with dependence and withdrawal, including benzodiazepines, z-drugs, antidepressants, gabapentinoids and opioids. NICE identified a lack of knowledge about the best model for such service delivery. Therefore, we performed a global survey of existing deprescribing services to identify common practices and inform service development.

Methods
We identified existing deprescribing services and interviewed key personnel in these services using an interview co-produced with researchers with lived experience of withdrawal. We summarised the common practices of the services and analysed the interviews using a rapid form of qualitative framework analysis.

Results
Thirteen deprescribing services were included (8 UK, 5 from other countries). The common practices in the services were: gradual tapering of medications often over more than a year, and reductions made in a broadly hyperbolic manner (smaller reductions as total dose became lower). Reductions were individualised so that withdrawal symptoms remained tolerable, with the patient leading this decision-making in most services. Support and reassurance were provided throughout the process, sometimes by means of telephone support lines. Psychosocial support for the management of underlying conditions (e.g. CBT, counselling) were provided by the service or through referral. Lived experience was often embedded in services through founders, hiring criteria, peer support and sources of information to guide tapering.

Conclusion
We found many common practices across existing deprescribing services around the world. We suggest that these ingredients are included in commissioning guidance of future services and suggest directions for further research to clarify best practice.
Patient with adrenal insufficiency due to a de novo mutation in the NR0B1 gene
Authors: Bravo Nieto Daniel , García Fernández Alba S. , Díaz Troyano Noelia , Arnaiz Marina Giralt , Arias García Andrea , Fernández Álvarez Paula , Campos Martorell Ariadna , Ferrer Costa Roser , Clemente León María 
Published: March 2023

Abstract

Objectives
Congenital X-linked adrenal hypoplasia is a rare disease with a known genetic basis characterized by adrenal insufficiency, hypogonadotropic hypogonadism, and a wide variety of clinical manifestations.

Case presentation
We present the case of a 26-day old male newborn with symptoms consistent with adrenal insufficiency, hyponatremia, and hyperkalemia. Following NaCl and fludrocortisone supplementation, the patient remained clinically stable. 17-OH-progesterone testing excluded congenital adrenal hyperplasia. The rest of hormones were within normal limits, except for adrenocorticotropic hormone (ACTH), which was significantly elevated, and aldosterone, which was below the reference value. Further testing included very long chain fatty acids to exclude adrenoleukodystrophy, the CYP11B2 gene (aldosterone synthase), and an MRI to screen for other morphological abnormalities. All tests yielded normal results. Finally, after cortisol deficiency was detected, expanded genetic testing revealed a mutation in the NR0B1 gene, which led to a diagnosis of congenital adrenal hypoplasia.

Conclusions
Diagnosis of congenital adrenal hypoplasia is challenging due to the heterogeneity of both clinical manifestations and laboratory abnormalities. As a result, diagnosis requires close monitoring and genetic testing.
Clinical evidence requirements according to the IVDR 2017/746: practical tools and references for underpinning clinical evidence of IVD-MDs
Authors: Charrière Karine , Pazart Lionel 
Published: March 2023

Abstract
In May 2022, the European Regulation 2017/746 (IVDR) came into force. It changes the approach of in vitro medical devices (IVD-MDs) for industry and institutions. It reinforces the clinical evidence requirements to improve performance, safety and transparency. Despite extended transition periods and existing guides, IVDR remains difficult to interpret and bringing devices into compliance requires efforts. The generation of clinical evidence is essential to demonstrate compliance with IVDR, and encompasses scientific validity, analytical performance and clinical performance. It is required to demonstrate, per intended use in the target population and clinical care pathway, IVD-MDs clinical performance (compared to a predefined clinical performance). Thus, there is a need for IVD-manufacturers and end-users in health care institutions, to obtain guidance on how to generate this clinical evidence. This article aims industrials and clinicians to identify key steps imposed by the IVDR for bringing IVD-MDs to the EU-market. We propose a general view of performance evaluation requirements for IVD-MDs and provide key references, including how to establish study design that will enable to document clinical performance of existing, refined or emerging medical tests. Finally, we propose a roadmap to address the relevant questions and studies in relation to the documents requested in the IVDR.
Mathematical model for conversion of groundwater flow from confined to unconfined aquifers with power law processes
Authors: Morakaladi Makosha Ishmaeline Charlotte , Atangana Abdon 
Published: March 2023

Abstract
In this work, we propose a mathematical model to depict the conversion of groundwater flow from confined to unconfined aquifers. The conversion problem occurs due to the heavy pumping of confined aquifers over time, which later leads to the depletion of an aquifer system. The phenomenon is an interesting one, hence several models have been developed and used to capture the process. However, one can point out that the model has limitations of its own, as it cannot capture the effect of fractures that exist in the aquitard. Therefore, we suggest a mathematical model where the classical differential operator that is based on the rate of change is substituted by a non-conventional one including the differential operator that can represent processes following the power law to capture the memory effect. Moreover, we revise the properties of the aquitard to evaluate and capture the behaviors of flow during the process in a different aquitard setting. Numerical analysis was performed on the new mathematical models and numerical solutions were obtained, as well as simulations for various fractional order values.
An 11-year-old girl with Autoimmune Polyglandular Syndrome (APS) type 2: a case report and review of literature
Authors: Bonataki Myrto , Dikaiakou Eirini , Anastasopoulou Panagiota , Fakiolas Stefanos , Kafetzi Maria , Vlachopapadopoulou Elpis Athina 
Published: March 2023

Abstract

Objectives
Autoimmune polyglandular syndrome type 2 (APS2) is characterized by autoimmune adrenal insufficiency (AI) in conjunction with autoimmune thyroid disease (AITD) and/or type 1 diabetes mellitus (T1DM). The aim is to report an 11-year-old girl with concurrence of Addison disease, celiac disease and thyroid autoimmunity.

Case presentation
She initially presented at the age of 5 with vomiting, dehydration, hyponatremia, hyperkalemia and low glucose. She recovered with intravenous hydration but the diagnosis was not established. She presented again at the age of 11 with hyperpigmentation, weakness and signs of impending adrenal crisis. Diagnosis of autoimmune AI was established together with celiac disease and thyroid autoimmunity. Thus, she met criteria for APS, being the third pediatric case report of APS2 with this combination.

Conclusions
This case is notable for the atypical age of onset, given that APS2 is rare in the pediatric population. Furthermore, it depicts the insidious course of Addison disease with symptoms fluctuating for years before diagnosis.
On the Origin of Transculturalism: A Study Into the Western Academic Context and its Chinese Translation
Authors: Zhang Xiaoying , Sheng Yang , Jiang Duo 
Published: March 2023

Abstract
The concept of transculturalism has often been used to describe the increasingly complicated interactions between different cultures under the circumstances of globalization. It is also widely used in international communication and intercultural studies in China, and is often translated into different Chinese concepts such as “跨文化” “超越文化” “转文化.” How can we better understand the meaning of this concept in different academic contexts? This paper discovered that this concept was developed as criticism of post-colonialism and that of Western cultural studies reflecting a worldview that is centered on Euro-centrism. The Chinese translation of transculturalism should accordingly vary in different academic discourses. The concept is of great significance to promote cultural equality, cultural connection and respect, cultural exchange and mutual learning. However, cultural competition and western-centrism embedded in Welsch’s definition of transculturalism is worthy of attention.
Exosomal miR-93-5p regulated the progression of osteoarthritis by targeting ADAMTS9
Authors: Li Yachen , Duan Junjun , Lin Weicheng , Liu Jie 
Published: March 2023

Abstract
Osteoarthritis (OA) is a type of common degenerative joint disorder, in which adipose mesenchymal stem cells (ADSCs) and the secreted exosomes play an important role. The purpose of this study was to investigate the role and mechanism of exosomes derived from ADSCs (ADSC-exos) in OA. The gradient of IL-1β concentration was designed to construct the articular chondrocyte model of arthritic mice. The expression of miR-93-5p and ADAMTS9 in articular chondrocytes was detected by reverse transcription quantitative polymerase chain reaction. Dual luciferase reporter gene assay was performed to verify the interaction between them. Monodansylcadaverine staining was used to visualize the autophagosome formation and cell apoptosis was analyzed by flow cytometry. ADSC-exos were authenticated by transmission electron microscope and western blot assay. miR-93-5p was found to be downregulated in IL-1β-treated articular chondrocytes compared with OA cartilage while ADAMTS9 was upregulated, which was identified as a direct target gene of miR-93-5p. Silencing of ADAMTS9 attenuated the effects of miR-93-5p. Exosomal miR-93-5p can reduce the release of inflammatory factors in mouse arthritis cell models. This study first described the mechanism under that ADSC-exos inhibited inflammation and alleviated OA through the innovative targets miR-93-5p/ADAMTS9 signal axis. This provided a new method for the treatment of OA.
Narrowband photoblinking InP/ZnSe/ZnS quantum dots for super-resolution multifocal structured illumination microscopy enhanced by optical fluctuation
Authors: Zhou Liangliang , Cao Huiqun , Huang Lilin , Jing Yingying , Wang Meiqin , Lin Danying , Yu Bin , Qu Junle 
Published: March 2023

Abstract
Cadmium-free quantum-dot (QD) fluorophores can bridge the gap between the macroscopic and microscopic domains in fluorescence super-resolution bioimaging. InP/ZnSe/ZnS QD photoblinking fluorescent probes can improve the performance of reactive super-resolution imaging techniques and spontaneously switch fluorophores between at least two states (open and close) without depending on intense laser light and specialized buffers for bioimaging. Multifocal structured illumination microscopy (MSIM) provides a two-fold resolution enhancement in sub-diffraction imaging, but higher resolutions are limited by the pattern frequency and signal-to-noise ratio. We exploit the synergy between MSIM and spontaneously switching InP/ZnSe/ZnS QD fluorophores to further increase the imaging resolution. We demonstrate the experimental combination of optical-fluctuation-enhanced super-resolution MSIM using ultrasonic-oscillation-assisted organic solvothermal synthesis of narrowband photoblinking InP/ZnSe/ZnS QDs. The InP/ZnSe/ZnS QDs show a monodisperse grain size of approximately 9 nm, fluorescence quantum yields close to 100%, and full width at half maximum below 30 nm. The structural, electronic, and optical properties are characterized through experiments and first-principles calculations. The enhanced MSIM imaging achieves an approximate fourfold improvement in resolution for fixed cells compared with widefield imaging. The proposed InP/ZnSe/ZnS QD fluorescent probes seem promising for super-resolution imaging using MSIM.
Growth promotion potential ofBacillusspp. isolates on two tomato (Solanum lycopersicumL.) varieties in the West region of Cameroon
Authors: Kouam Idriss Djoko , Mabah Joseline , Germain Ntsoli Pierre , Tchamani Laverdure , Yaouba Aoudou , Katte Bridget , Bitom Dieudonné 
Published: March 2023

AbstractInoculation of plants with plant growth-promoting bacteria (PGPB) is an ecological approach to improve plants growth and yield. The objective of this study was to screen native PGPBs in tomato root rhizosphere and evaluate their performance in germination and growth of seedlings in the greenhouse in the western region of Cameroon. Isolates were selected based on their ability to solubilize phosphate, produce indole-3-acetic acid, and improve seed germination and seedling growth under laboratory conditions. Following this screening, eight bacteria were selected (S1, S4, S13, S14, S16, B9, B11, and B15) to assess their performance on seedling growth in greenhouse. Seeds of two tomato varieties (one improved, Raja, and the local one, Foolewouh) were used in this study. The experiment was performed in sterilized and non-sterilized soils. Phylogenetic analysis of the 16S rRNA sequence showed that these bacteria belong to the genusBacillus, includingB. thuringiensis,B. cereus,B. pacificus, andB. aerius. The bacterial performance depended on the variety and conditions of soil treatment. Isolates improved seed germination (up to 31.93%) and seeding strength (up to 78.59%)in vitro. In greenhouse, inoculation with PGPB significantly increased stem height, root length, and weight of fresh and dry stems and roots. Raja variety was more sensitive to bacteria and performed better than the Foolewouh variety. Bacterial isolates on sterilized soil allowed to better seedling growth compared to non-sterilized soil. The study showed thatB. thuringiensis(strain B9),B. pacificus(strain B11), andBacillussp. (strain B15) can be used as inoculant formulations to improve seedling growth of tomato plant.
Analysis of the metaphorical meanings of symbols in Milan Kundera’s novels
Authors: Zhao Qian 
Published: March 2023

AbstractMilan Kundera is one of the most influential writers in contemporary world literature. In his novels, there are many symbolic metaphors related to numbers, dreams, and animals. Combing through the plots of Kundera’s novels, we can discover that among all the numbers, seven and twenty are used most frequently. These two numbers have rich metaphorical meanings. Besides, there are many other digital metaphors in Kundera’s novels, including 6, 4, etc. Apart from number symbols, Kundera has also inserted various kinds of dream symbols in his artistic creation. For Kundera, dreams are not just an individual’s physical and psychological activities, but also a continuation and supplement of real life. It can be concluded that dream narration is a perfect medium for the author to express his philosophical ideology. In addition, dream symbols also serve as an important medium for Kundera to demonstrate narrative skills and present important themes. In Kundera’s novels, animal symbols are integrated with the plots, revealing the personal traits of the relevant characters, and mirroring their spiritual world at the same time. Besides, Kundera also expressed his ecological ethics through the narration of animals’ death. In conclusion, the metaphorical meanings of different symbols in Kundera’s novels play an active role in highlighting the themes, revealing the inner thoughts of the characters, showing the special features of the characters, and expressing the author’s philosophical thoughts. These symbols help Kundera to break the limitations of time and space, which has become an important part of his polyphonic art. What’s more, Kundera has also tried to expand the original metaphorical meanings of these symbols to create some new poetic meanings.
How many resources can be saved by changing consumers’ automatic dishwashing behaviour?
Authors: Alt Thomas , Boivin Dorothée , Altan Mario , Kessler Arnd , Schmitz Angelika , Stamminger Rainer 
Published: March 2023

Abstract
Automatic dishwashers combine capital, energy, and water to provide a relevant household service, namely dishwashing. Consumer behaviour in using the automatic dishwasher influences to a great extend the environmental impact of such a device. But what simple and intuitive recommendation can be given to consumers to save energy and water while maintaining the cleaning performance? This task is investigated by modelling the resource consumption for automatic dishwashers in six European countries by considering the installed base of automatic dishwashers and recently surveyed consumer programme selection behavior. Using this model, a simulation is performed on how three simple recommendations on the programme selection would affect the overall consumption. As a result, more than 20% of the consumed energy can be saved by following these simple recommendations. To facilitate consumers’ actual adoption of the recommendations, this publication presents effective communication measures based on the science of consumer behaviour.
Identifying Texture and Friction of Asphalt Pavement Surface with Optimized Close-Range Photogrammetry Method
Authors: Chen Jun , Yuan Xiaowen , Liu Quan , Zhao Cheng , Zhou Ruoyu , Huang Jiale 
Published: March 2023

Abstract
An adequate pavement texture that provides sufficient brake friction is critical for drive safety. Thus, it is essential to quantify the pavement texture and friction efficiently and accurately. So far, the close-range photogrammetry (CRP) method has been manifested as a promising one. Nonetheless, related measurement parameters have not been well optimized toward its extensive promotion. For this reason, varying measurement parameters of CRP method were thoroughly discussed and optimized in this study. Additionally, the optimized CRP method was further validated using the sand patch test and X-ray computed tomography scan method. Based on this, the estimation of friction coefficients for asphalt concrete (AC-13), stone mastic asphalt (SMA-13), and open graded friction course (OGFC-13) were carried out. The results indicate the following: (1) the optimized CRP method was able to adequately feature the pavement macrotexture; (2) the mean texture depth derived from the CRP method was equivalent to the texture depth measured from sand patch method; in addition, (3) the OGFC asphalt mixture was superior to the SMA and AC asphalt mixtures in terms of the friction coefficients. The optimized CRP method could bring bright prospects for future measurements of pavement texture.