bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous cryoablation therapy for abdominal wall endometriosis: a systematic review and meta-analysis
Authors: Kaça do Carmo Letícia Helena , Brito Ceolin de Faria Stephanie , da Cruz Fagundes Marília , Costa de Oliveira Lima Laura , Verdan Moreira Sarah , Strieder de Oliveira Guilherme , Vidal Leão Renata , Mendes Junqueira de Barros Emanuela , Mariussi Miriana , Moretti Monsignore Lucas , Giansante Abud Daniel 
Published: January 2025

Abstract

Objectives
Abdominal wall endometriosis (AWE) consists of endometrial tissue between the peritoneum and the abdominal wall. The established treatment involves amenorrheic drugs—not always successful and tolerated—or invasive surgery. In this scenario, minimally invasive techniques such as cryoablation are a potential option. In this study, we primarily aimed to evaluate the efficacy of percutaneous cryoablation in reducing pain scores of AWE patients and analyze their satisfaction with the procedure and its related adverse events.

Materials and Methods
MEDLINE, EMBASE, and Cochrane’s databases were systematically searched for studies that employed percutaneous cryoablation therapy for AWE and reported any of the outcomes of interest. The primary outcome was the reduction in the visual analog scale (VAS) score after treatment. R Software was used for the statistical analysis. Heterogeneity was assessed using I2 statistics. The Risk Of Bias In Non-Randomized Studies—of Interventions framework assessed potential bias in each selected study.

Results
We included 4 studies, containing 126 patients. All articles were retrospective studies. The difference between the VAS scores before and after treatment was on average 5.97 points (95% CI 5.42-6.52; P &lt;.01; I2 = 0%). The pooled satisfaction rate among patients in the selected studies was 93.1% (95% CI 88.66-97.34; P = .51; I2 = 0%). The pooled prevalence of adverse events was only 5.48% (95% CI 1.71-11.20; P = .58; I2 = 0%). Bias analysis showed an overall moderate risk in all included articles.

Conclusion
Our study demonstrated that cryoablation could reduce pain complaints in patients, while presenting a low incidence rate of adverse effects. Randomized clinical trials with a larger number of patients are necessary for greater conclusions.

Advances in knowledge
(1) AWE affects about 3.5% of women. The standard treatment is invasive surgery. (2) This meta-analysis demonstrated that cryoablation can effectively reduce pain scores while presenting a low rate of adverse effects. (3) Cryoablation is a feasible treatment for AWE, furthermore allowing shorter hospital stays and few complications for the patients.
Prognostic relevance of CT-defined body composition in patients with acute bleeding undergoing endovascular embolization
Authors: Riegelbauer Simon , Mehdorn Matthias , Struck Manuel Florian , Tautenhahn Hans-Michael , Scheuermann Uwe , Ebel Sebastian , Denecke Timm , Meyer Hans-Jonas 
Published: January 2025

Abstract

Objectives
Body composition assessment includes the parameter skeletal muscle mass, subcutaneous and visceral adipose tissue (SAT and VAT). The purpose of this study was to elucidate associations of body composition parameters with mortality in patients with acute bleeding undergoing transarterial embolization (TAE).

Methods
A mixed cohort of patients from 2018 to 2022 with acute bleeding requiring treatment with a TAE was retrospectively evaluated. In every case, the triphasic CT to diagnose the source of bleeding was used to calculate the body composition parameters.

Results
A total of 251 patients (93 female, 37.1%) with a mean age of 65.5 ± 14.3 years, 30-d mortality of 40.2%, and 24-h mortality of 7.6% were included in the analysis. In the Cox regression analysis, no statistically significant correlations were found between the body composition parameters and 24-h or 30-day mortality. In the subgroup analysis of patients aged older than 65 years, skeletal muscle index was associated with short-term 24-h mortality HR of 0.95 (95% CI 0.90; 0.99, P = .035).

Conclusions
The present study demonstrated the prognostic impact of clinical, laboratory, aniography-related, and CT-defined body composition in patients with acute haemorrhage undergoing endovascular therapy. Although the overall effect of CT-defined body composition appears to be small, skeletal muscle index was a prognostic factor in the age group over 65 years.

Advances in knowledge
This is a large single-centre study to investigate the prognostic relevance of CT-defined body composition in patients undergoing TAE. The effect is overall small but might be further investigated in older patients in further trials.
Integrative taxonomic study of Coccoloba gracilis (Polygonaceae) and C. ruiziana from Amotape–Huancabamba neotropical biodiversity hotspot
Authors: Arnelas Itziar , Pérez-Collazos Ernesto , Armijos-Barros Jorge Luís , Fernanda Moreno-Aguilar María , Cueva-Agila Augusta , Ortiz-Díaz Juan Javier , Cornejo Xavier , Invernón Vanessa R 
Published: January 2025

Abstract
Accurate species delimitation is necessary to estimate species diversity. However, species delimitation remains challenging in the poorly studied Coccoloba genus in the northern Andes. Coccoloba gracilis and C. ruiziana are endemic related species inhabiting dry seasonal tropical forest of the Amotape–Huancabamba zone in Ecuador and Peru. The identity of C. ruiziana is widely recognized. However, some information about C. gracilis is missing and its identity has not been thoroughly checked by previous authors. We used morphological, phylogenetic, and ecological data in a robust methodological approach to investigate species boundaries. We studied 251 specimens from 17 herbaria, representing the entire distribution range of this species. Morphometric analysis suggested significant differentiation of multiple traits. Our phylogeny recovered Coccoloba gracilis related to C. ruiziana but with low statistical support. The results of ecological niche models showed a low levels of niche overlap between them. Our results support the recognition of two distinct species. Coccoloba gracilis Kunth emend. Arnelas mut. char., distributed in semi-deciduous, montane low forest and first rediscovered in Ecuador, and C. ruiziana, distributed at lower altitudes in lowland, dry seasonal tropical forest. Descriptions, photographs, and nomenclature notes are provided. One second-step lectotypification and one epitype for C. gracilis are provided.
Haemodynamic management of septic shock
Authors: Kotani Yuki , Ryan Nicholas , Udy Andrew A , Fujii Tomoko 
Published: January 2025

Abstract
Septic shock is a significant challenge in the management of patients with burns and traumatic injuries when complicated by infection, necessitating prompt and effective haemodynamic support. This review provides a comprehensive overview of current strategies for vasopressor and fluid management in septic shock, with the aim to optimize patient outcomes. With regard to vasopressor management, we elaborate on the pharmacologic profiles and clinical applications of catecholamines, vasopressin derivatives, angiotensin II, and other vasoactive agents. Noradrenaline remains central to septic shock management. The addition of vasopressin, when sequentially added to noradrenaline, offers a non-catecholaminergic vasoactive effect with some clinical benefits and risks of adverse effects. Emerging agents such as angiotensin II and hydroxocobalamin are highlighted for their roles in catecholamine-resistant vasodilatory shock. Next, for fluid management, crystalloids are currently preferred for initial resuscitation, with balanced crystalloids showing benefits over saline. The application of albumin in septic shock warrants further research. High-quality evidence does not support large-volume fluid resuscitation, and an individualized strategy based on haemodynamic parameters, including lactate clearance and capillary refill time, is recommended. The existing knowledge suggests that early vasopressor initiation, particularly noradrenaline, may be critical in cases where fluid resuscitation takes inadequate effect. Management of refractory septic shock remains challenging, with novel agents like angiotensin II and methylene blue showing potential in recent studies. In conclusion, Further research is needed to optimize haemodynamic management of septic shock, particularly in developing novel vasopressor usage and fluid management approaches.
Reactions, Reality, and Resilience in Adults with Crohn’s Disease: A Qualitative Study
Authors: Jones Katherine , Baker Katherine , Tew Garry A , Naisby Jenni 
Published: January 2025

Abstract

Background
Crohn’s disease (CD) is a lifelong condition that poses unique challenges. This study reports findings from a person’s perspective of living with CD to help enhance the understanding of an individual’s specific care and support needs.

Methods
Semi-structured telephone interviews were conducted with a convenience sample of adults with Crohn’s disease recruited from Newcastle Hospitals NHS Foundation Trust. Data were analyzed after data collection using thematic analysis.

Results
Forty-one (68% female) participants aged 49.1 ± 12 years with a disease duration between 1 and 55 years were interviewed. Three overarching themes emerged, along with 12 subthemes: (1) reactions to presenting symptoms, emotions, and challenges at diagnosis; (2) reality of living with the condition, seeking information, decision making, psychological challenges, experiencing symptoms/complications during remission and the impact on social life, education, employment, and relationships; (3) Resilience involving emotional adaptations, strategies on self-management, social comparisons as a means of coping and barriers to resilience.

Conclusions
The results highlight the complex health journey and challenges faced by people living with Crohn’s disease and provide health care professionals with a greater insight into the psychological challenges and emotional complexities of the condition to facilitate a more holistic approach to planning care.
Ischaemia with non-obstructive coronary arteries in the 2024 European Society of Cardiology guidelines for the management of chronic coronary syndromes
Authors: Reynolds Harmony R , Smilowitz Nathaniel R 
Published: January 2025

Abstract

Aims
Chronic coronary syndromes (CCS) occur commonly in the absence of flow-limiting epicardial coronary stenosis. Ischaemia or angina with non-obstructive coronary arteries (INOCA/ANOCA) may be caused by coronary microvascular disease, coronary artery spasm, myocardial bridging, diffuse atherosclerosis, or a combination of disorders.

Methods and results
We highlight the new recommendations in the 2024 European Society of Cardiology (ESC) guidelines on CCS relevant to the diagnosis and management of INOCA/ANOCA. The guidelines place a new emphasis on consideration of INOCA/ANOCA early during cardiovascular risk stratification and the initial diagnostic workup for chest pain. There is a new Class I recommendation for the availability of invasive coronary function testing (CFT) at the time of initial coronary angiography, when the mechanisms of chest pain are uncertain after non-invasive testing, and in patients with established INOCA/ANOCA who have persistent symptoms and poor quality of life despite medical therapy. Once underlying disorders have been identified based on the results of invasive CFT, the ESC guidelines emphasize a patient-centred, mechanism-based approach to medical treatment of INOCA/ANOCA to improve the symptoms and quality of life.

Conclusion
The 2024 ESC CCS guidelines provide a new vision for the diagnosis and management of ANOCA/INOCA, with an expanded role for invasive CFT and targeted medical therapy to improve symptoms and quality of life in patients with angina.
Risk profile and prognostic implications of premature advanced coronary atherosclerotic disease among young to early middle-aged adults: the coronary artery calcium consortium
Authors: Boakye Ellen , Dehesh Mohammadmoein , Dardari Zeina , Obisesan Olufunmilayo H , Osei Albert D , Dzaye Omar , Jha Kunal , Rozanski Alan , Berman Daniel S , Budoff Matthew J , Miedema Michael D , Nasir Khurram , Rumberger John A , Shaw Leslee J , Blaha Michael J 
Published: January 2025

Abstract

Aims
Premature advanced subclinical coronary atherosclerosis among young adults is an under-recognized and unique disease phenotype that has not been well characterized.

Methods and results
We used data from 44 047 participants with no prior CVD history (59.8% male) from the Coronary Artery Calcium (CAC) Consortium. We defined advanced disease as CAC ≥ 90th percentile for age, sex, and race and compared the risk factor profile of persons with advanced disease to those without CAC and those with CAC &lt; 90th percentile. Using multivariable-adjusted Cox proportional hazard and competing risks regression, we assessed the association of premature advanced disease with all-cause, cardiovascular, and coronary heart disease (CHD) mortality. Of 44 047 participants, 18 561 (42.2%) had CAC. Among those with CAC, 6680 (36.0%) had CAC ≥ 90th percentile. Notably, 76.4% of those with CAC ≥ 90th percentile had multivessel CAC compared with 40.6% of those with CAC &lt; 90th percentile. After a mean follow-up of 12.5 ± 3.6 years, the incidence per 1000 person-years of all-cause (2.93 vs. 1.85 vs. 1.11), cardiovascular (1.11 vs. 0.39 vs. 0.21), and CHD mortality (0.65 vs. 0.19 vs. 0.08) was highest in the advanced disease group compared with CAC &lt; 90th percentile and the no CAC group. Persons with CAC ≥ 90th percentile had a higher multivariable-adjusted risk of all-cause [HR: 2.17 (1.83–2.57)], cardiovascular [sub-distribution hazard ratios (SHR): 3.89 (2.78–5.44)], and CHD mortality [SHR: 5.45 (3.38–8.78)], compared with those without CAC. In the subgroup analysis, there was no difference in mortality between men and women with advanced CAC.

Conclusion
Premature advanced atherosclerosis is a distinct clinical phenotype that strongly predicts all-cause and cause-specific mortality. Among persons with CAC at young age, those with scores ≥90th percentile have the highest risk of early death and should be identified in future guidelines as a focus for aggressive clinical prevention.
Descriptive analysis of protein expression variations during pupal development of Chrysomya megacephala (Diptera: Calliphoridae) using label-free proteomic techniques
Authors: Long Ren , Luo Chengyong , Zhang Peng , Zou Xing , Song Tao 
Published: January 2025

Abstract
Age estimation is a critical aspect of forensic entomology, especially in the examination of pupae. The use of proteins as a means for age identification shows great promise. In this study, proteomic techniques were employed to investigate differentially expressed proteins (DEPs) during the intrapuparial stage of Chrysomya megacephala. Specimens were sampled at four distinct time points: 0 h (Group A), 24 h (Group B), 48 h (Group C), and 72 h (Group D). Our analysis uncovered 56 DEPs between Groups B and A, 116 DEPs between Groups C and A, and a total of 152 DEPs between Groups D and A. These DEPs were categorized into nine clusters based on their expression patterns. Cluster 1 exhibited an increasing trend in protein expression, while Cluster 4 displayed the opposite pattern. Clusters 2, 6, and 9 showed an initial rise followed by a decline, whereas Cluster 3 demonstrated the reverse trend. Cluster 8 indicated an initial rise, a subsequent drop, and another rise, while Cluster 7 showed an initial decrease, followed by an increase and a minor decrease. Notably, the C-type lectin domain-containing (CTLD) protein and Failed axon connections (Fax) protein consistently displayed an upward trend. These two DEPs were selected for validation using the parallel reaction monitoring technique (PRM)-targeted proteomics, confirming the trends observed in the initial analysis. In summary, this study highlights the potential of using proteins as reliable biomarkers for estimating pupal age.
Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites
Authors: Faquih Tariq O , van Hylckama Vlieg Astrid , Surendran Praveen , Butterworth Adam S , Li-Gao Ruifang , de Mutsert Renée , Rosendaal Frits R , Noordam Raymond , van Heemst Diana , Willems van Dijk Ko , Mook-Kanamori Dennis O 
Published: January 2025

Abstract
Chronological age is a major risk factor for numerous diseases. However, chronological age does not capture the complex biological aging process. The difference between chronological age and biologically driven aging could be more informative in reflecting health status. Here, we set out to develop a metabolomic age prediction model by applying ridge regression and bootstrapping with 826 metabolites (678 endogenous and 148 xenobiotics) measured by an untargeted platform in relatively healthy blood donors aged 18–75 years from the INTERVAL study (N = 11 977; 50.2% men). After bootstrapping internal validation, the metabolomic age prediction models demonstrated high performance with an adjusted R2 of 0.83 using all metabolites and 0.82 using only endogenous metabolites. The former was significantly associated with obesity and cardiovascular disease in the Netherlands Epidemiology of Obesity study (N = 599; 47.0% men; age range = 45–65) due to the contribution of medication-derived metabolites—namely salicylate and ibuprofen—and environmental exposures such as cotinine. Additional metabolomic age prediction models using all metabolites were developed for men and women separately. The models had high performance (R² = 0.85 and 0.86) but shared a moderate correlation of 0.72. Furthermore, we observed 163 sex-dimorphic metabolites, including threonine, glycine, cholesterol, and androgenic and progesterone-related metabolites. Our strongest predictors across all models were novel and included hydroxyasparagine (Model Endo + Xeno β = 4.74), vanillylmandelate (β = 4.07), and 5,6-dihydrouridine (β = −4.2). Our study presents a robust metabolomic age model that reveals distinct sex-based age-related metabolic patterns and illustrates the value of including xenobiotic to enhance metabolomic prediction accuracy.
Estimation of the landslide source for the 1929 Grand Banks event using a deep-sea landslide tsunami simulation
Authors: Nakagaki Tatsuya , Tanioka Yuichiro 
Published: January 2025

SUMMARY
The 1929 Grand Banks earthquake (Mw 7.1) generated a large landslide that broke submarine cables near the source area. A large tsunami was generated by the large landslide that killed 28 people on the southern coast of the Burin Peninsula, Canada. The tsunami was also observed at a tide gauge in Halifax, Canada. In this study, the initial landslide mass distribution was estimated by fitting the first pulse of the tsunami waveform observed at Halifax and the timings of the submarine cable break with those computed values. A deep-sea landslide tsunami computation method was developed by modifying a previously developed Tsunami Squares method with a different friction term and an effect of deep water. The results showed that the tsunami waveform and timing of the cable break were well explained by the tsunami computed from the initial landslide mass volume of about 450 $\mathrm{km^3}$ located along the continental slope near the source area. The method developed to compute deep-sea landslide tsunamis should be useful for studying other types of landslide tsunamis.
Coding intensity variation in Medicare Advantage
Authors: Curto Vilsa E , Politzer Eran , Anderson Timothy S , Ayanian John Z , Souza Jeffrey , Zaslavsky Alan M , Landon Bruce E 
Published: January 2025

Abstract
Enrollment in Medicare Advantage (MA) plans rose to over 50% of eligible Medicare patients in 2023. Payments to MA plans incorporate risk scores that are largely based on patient diagnoses from the prior year, which incentivizes MA plans to code diagnoses more intensively. We estimated coding inflation rates for individual MA contracts using a method that allows for differential selection into contracts based on patient health. We illustrate the method using data on MA risk scores and health conditions from the most recent year available, 2014. This approach could also be used beginning in 2022, when Medicare transitioned to MA risk scores based on MA Encounter records. Several existing methods assess coding intensity, but this study's approach is novel in its use of plan-level mortality rates to infer plan-level coding intensity. We found an enrollment-weighted mean coding inflation rate of 8.4%, with rates ranging from 3.4% to 12.7% for the largest 8 MA insurers and from 1.1% to 22.2% for the largest 20 MA contracts in 2014. We found higher coding intensity for health plans that were HMOs, provider-owned, large, older, or had high star ratings. Approximately 68.1% of MA enrollees were in contracts with coding inflation rates larger than Medicare's coding intensity adjustment.
Modulation of morphogenesis and metabolism by plant cell biomechanics: From model plants to traditional herbs
Authors: Wang Zhengpeng , Ye Xiaoming , Huang Luqi , Yuan Yuan 
Published: January 2025

Abstract
The quality of traditional herbs depends on organ morphogenesis and the accumulation of active pharmaceutical ingredients. While recent research highlights the significance of cell mechanobiology in model plant morphogenesis, our understanding of mechanical signal initiation and transduction in traditional herbs remains incomplete. Recent studies reveal a close correlation between cell wall (CW) biosynthesis and active ingredient production, yet the role of cell mechanics in balancing morphogenesis and secondary metabolism is often overlooked. This review explores how the cell wall, plasma membrane, cytoskeleton, and vacuole collaborate to regulate cell mechanics and respond to mechanical changes. We propose CW biosynthesis as a hub in connecting cell mechanics with secondary metabolism and emphasize that understanding the relationship between mechanical remodeling and secondary metabolism could provide new insights into plant cell mechanobiology and the breeding of high-quality herbs.
Social life cycle assessment of industrial gold mining in Mali
Authors: Konaré Zan Mary , Ajayi Dickson Dare , Ba Sidy , Aremu Ademola Kabiru 
Published: January 2025

Abstract
Gold mining in Mali contributes significantly to the country's socioeconomic growth, employing hundreds of people and generating considerable export revenues and income. At the same time, gold mining still has a bad reputation in public opinion due to the environmental and socioeconomic challenges it poses. It is therefore important to integrate Mali's gold mining sector into a framework of social responsibility, using the social life cycle assessment (S-LCA) approach to identify and understand social opportunities and challenges. This study focuses on an application of the S-LCA approach to assess the social performance of industrial gold mining in Mali. Primary data were collected from company representatives, workers, and local communities. The results of the study show that in 85.2% of ratings, the company has at least good performance and poor performance in 14.8% of ratings. The results show also that excessive working hours, corruption, sexual harassment, and discrimination are identified as social hotspots in the gold mines in Mali. This article provides a useful addition to the literature on the application of S-LCA and for political and administrative decision-makers in the sector to promote fact-driven policies for socially profitable gold mining. Further research would be useful to address the hotspots identified, particularly with regard to the effective management of labor and the prevention of corruption and sexual harassment.