bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hoarseness as the initial presentation of multiple myeloma
Authors: Colebunders Jules , Hellemans Stig , Ahmed Melek , Libbrecht Sasha , de Bruijn Sévérine 
Published: May 2023

Key Clinical MessageMyeloma of the thyroid cartilage is a rare but important differential diagnosis of a laryngeal mass. Although hoarseness as the initial presenting symptom in multiple myeloma is extremely rare, a clinician should always consider it.AbstractMultiple myeloma (MM) is a malignant plasma cell disorder characterized by an uncontrolled proliferation of monoclonal plasma cells. Although the clinical presentation at diagnosis can be quite variable, thyroid cartilage infiltration in MM is rare. Here we discuss a 65‐year‐old Caucasian male presenting to the ENT doctor with continuous hoarseness for 3 months. The initial clinical examination showed a tangible mass at the left lymph node level II–III. Further examination with fiber‐optic laryngoscopy showed a bulging of the aryepiglottic and ventricular fold. Neck and chest CT scan revealed multiple osteolytic bone lesions in addition to the large lesion in the left thyroid cartilage. Laboratory work‐up, PET‐CT scan and biopsy of the thyroid cartilage were performed and eventually all confirmed the presence of a new diagnosis of IgA kappa MM. The patient was referred to the department of hematology to start with chemotherapy.
Platelet‐rich plasma in the treatment of alopecia areata after COVID‐19 vaccination
Authors: Teng Hsiang‐Chiun , Chen Hsin‐Hsu 
Published: May 2023

Key Clinical MessageAlopecia areata may develop in patients after COVID‐19 vaccination. Platelet‐rich plasma (PRP) has an outstanding anti‐inflammatory effect and could be an alternative treatment for alopecia patients who are refractory or intolerant to corticosteroids.AbstractA 34‐year‐old female with no systemic illness presented with non‐scarring hair loss after the second COVID‐19 vaccination shot 4 weeks ago. The hair loss worsened and progressed to severe alopecia areata. We started double‐spin PRP therapy. Her hair recovered completely after six courses of PRP treatment.
Dedicated to Edmund R. Malinowski. Secondary, model‐based examination of model‐free analysis results: Making the most of soft‐modelling outcomes
Authors: Maeder Marcel 
Published: May 2023

AbstractEdmund R. Malinowski is well known for his factor analysis‐based work; he is clearly less well known for his chemical model‐based analyses of chemical data. In this contribution, we discuss the, at the time innovative, idea of subjecting the primary model‐free analysis results to a secondary quantitative model‐based evaluation. Two examples from his research serve as illustrations: the complexation of Cu2+ with cyclodextrin and the dimerisation and trimerisation of methylene blue. In both examples, the spectrophotometric titration data are first analysed by window factor analysis, WFA, resulting in the concentration profiles. These primary, model‐free results allowed Malinowski to gain qualitative insight in the chemical processes. Additional quantitative analyses of the concentration profiles, based on the previously obtained reaction model, resulted in the numerical values of the underlying equilibrium constants. This contribution relates and compares this methodology with alternative ways of analysing the same data.
Smart Temperature‐Gating and Ion Conductivity Control of Grafted Anodic Aluminum Oxide Membranes
Authors: Lee Min‐Jie , Chen Yi‐Fan , Lee Lin‐Ruei , Lin Yu‐Liang , Zheng Sheng , Chang Ming‐Hsuan , Chen Jiun‐Tai 
Published: May 2023

AbstractOver the past few decades, stimuli‐responsive materials have been widely applied to porous surfaces. Permeability and conductivity control of ions confined in nanochannels modified with stimuli‐responsive materials, however, have been less investigated. In this work, the permeability and conductivity control of ions confined in nanochannels of anodic aluminum oxide (AAO) templates modified with thermo‐responsive poly(N‐isopropylacrylamide) (PNIPAM) brushes are demonstrated. By surface‐initiated atom transfer radical polymerization (SI‐ATRP), PNIPAM brushes are successfully grafted onto the hexagonally packed cylindrical nanopores of AAO templates. The surface hydrophilicities of the membranes can be reversibly altered because of the lower critical solution temperature (LCST) behavior of the PNIPAM polymer brushes. From electrochemical impedance spectroscopy (EIS) analysis, the temperature‐gating behaviors of the AAO‐g‐PNIPAM membranes exhibit larger impedance changes than those of the pure AAO membranes at higher temperatures because of the aggregation of the grafted PNIPAM chains. The reversible surface properties caused by the extended and collapsed states of the polymer chains are also demonstrated by dye release tests. The smart thermo‐gated and ion‐controlled nanoporous membranes are suitable for future smart membrane applications.
Synthesis of Tetrathiophosphates from White Phosphorus
Authors: He Jiali , Shi Shanshan , Zhang Yumeng , Zhang Yang , Xu Pengxiang , Tang Guo , Zhao Yufen 
Published: May 2023

Comprehensive SummaryA transition‐metal‐free one‐pot direct synthesis of tetrathiophosphates (R1S)2P(S)SR2 from white phosphorus (P4), through intermediate sodium alkyltetrathiophosphates (R1S)2P(S)SNa, is presented. In the presence of NaSH, various disulfides such as diaryl disulfidbges and dialkyl disulfides are easily coupled with P4 to give sodium alkyltetrathiophosphates (R1S)2P(S)SNa in almost quantitative yield, which react with alkyl halides in one pot to generate (R1S)2P(S)SR2. Furthermore, S‐(2‐cyanoethyl)‐substituted tetrathiophosphates (R1S)2P(S)SCH2CH2CN are successfully designed as a kind of tetrathiophosphorylation reagent to react with diaryl iodonium salts involving deprotection‐dealkylation process.
Identification of m6A‐related lncRNAs as prognostic signature within colon tumor immune microenvironment
Authors: Cao Lichao , Zhang Shenrui , Ba Ying , Zhang Hezi 
Published: May 2023

AbstractBackgroundThe current study probed prognosis‐related potential for m6A‐related lncRNAs signatures within colon tumor immune microenvironment (TIM).MethodsAfter downloading transcriptomic datasets for colon cancer (CC) patients from The Cancer Genome Atlas (TCGA), they were divided, in a 1:1 ratio, within training or test datasets. m6A‐related lncRNAs were then scrutinized across such dataset using Pearson correlation assessment before generating a m6A‐related lncRNAs prognosis‐related model using the training dataset. The latter was then validated with the test and the whole dataset. In addition, we compared the differences of TIM and the estimated IC50 of drug response between the high‐ and low‐risk groups.ResultsOverall survival (OS) resulted as linked with 11 m6A‐related lncRNAs, while within the developed prognosis‐related model, areas‐under‐curves were as follows: within training dataset, values at 3‐, 4‐, and 5‐years were 0.777, 0.819, and 0.805, accordingly, and for test one, they were 0.697, 0.682, and 0.706, respectively. Finally, the values for the whole dataset were 0.675 (3‐year), 0.682 (4‐years), and 0.679 (5‐years), accordingly. Moreover, CC cases categorized within low‐risk cohort demonstrated enhanced OS (p < .0001), lower metastasis (p = 2e‐06) and lower T stage (p = .0067), more instability for microsatellite status (p = .012), and downregulation for PD‐L1, PD‐1, CTLA‐4, LAG3, and HAVCR2 (p < .05). In addition, risk scorings were significantly linked to the degree of infiltrative intensity for CD8 and CD4 (memory resting) T‐cells, T‐regulatory (Tregs), and Mast cells triggering (p < .05). Patients with low infiltrative propensity for CD4 T‐cells also had better OS (p = .016). Moreover, six representative drugs were found to be sensitive for treating CC patients.ConclusionA robust m6A‐related prognostic model with great performances was developed before exploring the TIM characteristics and its potential therapeutic drugs, which might improve the prognosis and therapeutic efficacy.
Testing methods to estimate spectral reflectance using datasets under different illuminants
Authors: Xu Jinghong , Luo Ming Ronnier , Fan Hui 
Published: May 2023

AbstractWith the rapid development of mobile imaging devices, there is a strong desire for accurate image reconstruction. However, the conventional colorimetry system is often related to environmental illuminations. Spectral reflectance is the fingerprint of color and is invariant with environmental illuminations. Therefore, the goal of the present study is to verify different algorithms to reconstruct the spectral reflectance from the camera red, green, and blue responses. In this research, the weighted local sample selection method was first combined with pseudo inverse matrix method (PI) and Wiener estimation method (WE) to investigate the optimal sample number on the model accuracy. The optimum local sample numbers of the two combination methods were established. The performance of five methods was evaluated, including PI, WE, smoothing constraint method, weighted pseudo inverse matrix method (WPI) and weighted Wiener estimation method (WWE) under lightings varying a wide range of correlated color temperature (CCT) from 3000 to 10 000 K. The best algorithm (WPI) in different lighting environments was established. The metamerism of different materials was revealed, the impact of materials on training and testing samples was reported. Finally, the methods' performance under different CCTs was revealed in terms of root mean square error and CIEDE2000, and the results from the theoretical simulation and real camera capturing were compared.
Strain‐Tunable Photocatalytic Performance in Two‐Dimensional Janus In2S2X (X=Se,Te) Monolayer as Photocatalyst for CO2 Reduction
Authors: Chen Zhengnan , Chi YuHua , Ma Hao , Yuan Saifei , Hao Chunlian , Ren Hao , Zhao Wen , Zhu HouYu , Guo Wenyue 
Published: May 2023

AbstractStrain engineering has been widely used in the study of two‐dimensional semiconductors in recent years, because it can improve catalytic performance by changing the structural characteristics of materials. In this work, we systematically investigate the effects of biaxial strain on the electronic structure, band‐edge positions, and optical absorption of perfect Janus In2S2X (X=Se, Te) particles and vacancy In2S2X (V‐In2S2X). Biaxial strain enables In2S2X to achieve a transition between indirect and direct band gaps. Tensile strain reduces the band‐edge potential of the conduction band minimum (CBM), but compressive strain increases it and then tends to stabilize the material. In V‐In2S2X, the tensile strain makes the top bands of the bandgap overlap with the CBM and moves the bottom band of the bandgap down, reducing the bandgap, which makes the light absorption range redshift. Most importantly, we demonstrate that V‐In2S2X obtains excellent photocatalytic CO2 reduction performance under 4 % tensile strain, broadening its practical applications in many fields.
Analysis of repeated measures data through mixed models: An application in Theobroma grandiflorum breeding
Authors: Chaves Saulo F. S. , Alves Rodrigo S. , Dias Luiz A. S. , Alves Rafael M. , Dias Kaio O. G. , Evangelista Jeniffer S. P. C. 
Published: May 2023

AbstractTheobroma grandiflorum is a perennial fruit tree native to the Amazon region. As a perennial species with continuous production throughout the years, breeders should seek well‐conducted trials, accurate phenotyping and adequate statistical models for genetic evaluation and selection that can leverage the information provided by the repeated measures. We evaluated 13 models with different covariance structures for genetic and residual effects for T. grandiflorum evaluation, using an unbalanced dataset with 34 hybrids from the triple‐crossing of nine parents, planted in a randomized complete block design. For nine consecutive years, the fruit yield of these hybrids was evaluated. Each model had its goodness‐of‐fit tested by the Akaike information criterion. The most adequate model for estimating the variance components and the breeding values were modelled with the first‐order heterogeneous autoregressive for residual effects and third‐order factor analytic for genetic effects. From this model, we used the factor analytic selection tools for selecting the top 10 families, providing a genetic gain of 10.42%. These results are important not only for T. grandiflorum breeding but also to show that in any repeated measures' data from fruit‐bearing perennial species the modelling of genetic and residual effects should not be neglected.
Design and development of dynamic Agri‐ontology for IoT interoperability
Authors: Khatoon P Salma , Ahmed Muqeem 
Published: May 2023

SummaryIn recent years, the usage and applications of Internet of Things (IoT) have increased exponentially. IoT connects multiple heterogeneous devices like sensors, micro controllers, actuators, smart devices like mobiles, watches, etc. IoT contributes the data produced in the context of data collection, including the domains like military, agriculture, healthcare, etc. The diversity of possible applications at the intersection of the IoT and the web semantics has prompted many research teams to work at the interface between these two disciplines. This makes it possible to collect data and control various objects in transparent way. The challenge lies in the use of this data. Ontologies address this challenge to meet specific data needs in the IoT field. This paper presents the implementation of a dynamic agriculture ontology‐building tool that parses the ontology files to extract full data and update it based on the user needs. The technology is used to create the angular library for parsing the OWL files. The proposed ontology framework would accept user‐defined ontologies and provide an interface for an online updating of the owl files to ensure the interoperability in the agriculture IoT.
THIP: A trajectory history‐based indoor positioning algorithm using stress‐free floor plan for patient monitoring
Authors: Jalali Mohammad Reza , Kheirabadi Mohammad Taghi 
Published: May 2023

SummaryThe Internet of Things (IoT) is a novel paradigm that consists of a wide network of machines and intelligent devices with the capability of communication and interaction with each other. One of the significant issues for the IoT is its healthcare applications. The positioning systems based on their environment can be classified into two main categories: Indoor and outdoor. Recently, IoT indoor positioning attracts too much attention among researchers for patient monitoring. Hence, in this paper, a stress‐free floor plan indoor positioning algorithm for patient monitoring is proposed, called THIP. The history of the patient's movement is stored in a trajectory history, and this information is employed to estimate the patient's more accurate position. The proposed THIP algorithm is simulated in MATLAB software. Several experiments are conducted to evaluate the performance of the proposed algorithm. Simulation results show that the proposed THIP algorithm raises patient positioning accuracy and declines the distance error cumulative compared to LiFS by about 4.68% and 60.6 m, respectively. Moreover, it can identify the floor level of the moving user.
The use of nitrous oxide whippets as a recreational drug: Hidden health risks
Authors: Desmedt Bart , Verleysen Eveline , Demaegdt Heidi , van Campenhout Peter , van Miert Erik , Deconinck Eric 
Published: May 2023

AbstractWhipped cream canisters, also known as nitrous oxide whippets, are traditionally used in the culinary arts to prepare food foams. In recent years, however, these gas canisters have been cracked open and inhaled to produce a “legal” high. Users of these whippets have reported the presence of an oily residue containing metallic particles. This contamination was investigated using liquid chromatography‐, gas chromatography‐ and inductively coupled plasma‐mass spectrometry (ICP‐MS) and optical emission spectrometry (ICP‐OES). The particulate matter was also analyzed by scanning transmission electron microscopy (STEM) combined with energy‐dispersive X‐ray spectroscopy (EDX). The presence of cyclohexyl isothiocyanate was confirmed at a maximum concentration of 67 μg per whippet. ICP‐MS and ICP‐OES analysis revealed the presence of mainly iron and zinc, but also, traces of aluminum, chromium, cobalt, nickel, and lead were found. STEM‐EDX analysis confirmed the presence of nano‐sized particles containing iron and zinc. When simulating inhalation, using the multiple path particle dosimetry model, it was confirmed that these nano‐sized particles can reach the deeper parts of the lungs. Most users assume that inhaling a food‐grade nitrous oxide whippet for a “legal” high poses no risks. However, this research shows that users are exposed to cyclohexyl isothiocyanate, a substance classified as a respiratory sensitizer. The presence of zinc in the particulate matter could potentially be linked to lung lesions.
Association between mean arterial pressure and clinical outcomes among patients with heart failure
Authors: Gao Qi , Lin Yuxin , Xu Ruqi , Zhang Yuping , Luo Fan , Chen Ruixuan , Li Pingping , Nie Sheng , Li Yanqin , Su Licong 
Published: May 2023

AbstractAimsMean arterial pressure (MAP) is widely used for evaluating organ perfusion, but its impact on clinical outcomes in patients with heart failure (HF) remains poorly understood. The aim of this study is to investigate the relationship between MAP and all‐cause mortality and readmission in patients with HF.Methods and resultsWe retrospectively analysed data from PhysioNet, involving 2005 patients with HF admitted to Zigong Fourth People's Hospital between 2016 and 2019. The primary outcomes were composite outcomes of all‐cause mortality and readmission at 3 and 6 months. The secondary outcomes were readmission at 3 and 6 months. Multivariate‐adjusted Cox regression models, restricted cubic spline curves (RCS), and propensity score matching (PSM) were used to explore the relationship between MAP and clinical outcomes. Among 2005 patients with HF [≥70 years, 1460 (72.8%); male, 843 (42.0%)], the incidence of primary outcome at 3 months was 33.4% (223/668), 24.4% (163/668), and 22.7% (152/669), and at 6 months, it was 47.5% (317/668), 38.5% (257/668), and 38.0% (254/669) across MAP tertiles [from Tertile 1 (T1) to Tertile 3 (T3)], respectively. The RCS showed an ‘L‐shaped’ relationship between MAP and primary or secondary endpoints. Multivariate‐adjusted Cox models showed that a higher MAP was significantly associated with a lower risk of composite endpoints at 3 months [adjusted hazard ratio (aHR) 0.75, 95% confidence interval (CI) 0.61–0.92, P = 0.006, Tertile 2 (T2); aHR 0.69, 95% CI 0.56–0.86, P = 0.001, T3] and 6 months (aHR 0.79, 95% CI 0.67–0.93, P = 0.005, T2; aHR 0.77, 95% CI 0.64–0.91, P = 0.003, T3) compared with T1. After 1:1 PSM, the effect of maintaining a relatively higher MAP was slightly attenuated. Threshold analyses indicated that per 10 mmHg increase in MAP, there was a 21% and 14% decrease in composite endpoints at 3 and 6 months, respectively (aHR 0.79, 95% CI 0.69–0.91, P = 0.001), and 6 months (aHR 0.86, 95% CI 0.77–0.97, P = 0.013) in patients with MAP ≤ 93 mmHg. The associations were consistent in readmission (secondary outcomes), various subgroups, and sensitivity analysis.ConclusionsA higher MAP was associated with a lower risk of a composite of all‐cause mortality and readmission. Maintaining a relatively higher MAP could potentially improve the clinical prognosis for patients with HF.
Isoform‐specific functions of Ras in T‐cell development and differentiation
Authors: Bodhale Neelam , Nair Arathi , Saha Bhaskar 
Published: May 2023

AbstractRas GTPases, well characterized for their role in oncogenesis, are the cells’ molecular switches that signal to maintain immune homeostasis through cellular development, proliferation, differentiation, survival, and apoptosis. In the immune system, T cells are the central players that cause autoimmunity if dysregulated. Antigen‐specific T‐cell receptor (TCR) stimulation activates Ras‐isoforms, which exhibit isoform‐specific activator and effector requirements, functional specificities, and a selective role in T‐cell development and differentiation. Recent studies show the role of Ras in T‐cell‐mediated autoimmune diseases; however, there is a scarcity of knowledge about the role of Ras in T‐cell development and differentiation. To date, limited studies have demonstrated Ras activation in response to positive and negative selection signals and Ras isoform‐specific signaling, including subcellular signaling, in immune cells. The knowledge of isoform‐specific functions of Ras in T cells is essential, but still inadequate to develop the T‐cell‐targeted Ras isoform‐specific treatment strategies for the diseases caused by altered Ras‐isoform expression and activation in T cells. In this review, we discuss the role of Ras in T‐cell development and differentiation, critically analyzing the isoform‐specific functions.
A novel strategy for fabrication, activation and cleaning of fully 3D printed flexible planar electrochemical platforms
Authors: Grazioli Cristian , Svigelj Rossella , Dossi Nicolò 
Published: May 2023

AbstractIn recent years, 3D printing of carbon‐based conductive filaments has received growing attention for assembling electrodes to be used in a wide variety of electroanalytical devices and applications. Despite the large amount of work present in literature concerning the development of three‐dimensional (3D) conductive structures, its potential as dry deposition method for assembling two‐dimensional (2D) electrodes to be used in planar configuration is still largely unexplored. In fact, the possibility to rapidly change the geometry of the electrochemical circuits, associated with the reduction of waste and the absence of solvents, which are instead important components of ink and paste formulations, makes this strategy a valid green and efficient alternative to other deposition approaches such as screen‐printing technology. We report here a rapid and solvent‐free method for assembling fully 3D printed flexible planar electroanalytical platforms (3DEPs) to be used with microliters of liquid. At the same time, a novel protocol for the surface pre‐treatment of 3D printed electrodes based on ultrasonication in aqueous NaOH solution followed by electrochemical activation using the same medium, is presented. In addition, the same procedure has proved to be efficient for cleaning the electrode surface after electrochemical passivation, thus confirming the validity of both time‐efficient and environmentally‐friendly assembling and activation/cleaning procedures developed which allow efficient and reusable electrodes to be produced. Finally, 3DEPs were tested by a proof‐of‐concept quantification of a commonly used food dye (Brilliant Blue, E‐133) in commercial solutions used for homemade food coloring.