bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact on glucometric variables and quality of life of the advanced hybrid closed‐loop system in pediatric and adolescent type 1 diabetes
Authors: Lendínez‐Jurado Alfonso , Gómez‐Perea Ana , Ariza‐Jiménez Ana B. , Tapia‐Ceballos Leopoldo , Becerra‐Paz Icía , Martos‐Lirio María F. , Moreno‐Jabato Fernando , Leiva‐Gea Isabel 
Published: June 2023

AbstractBackgroundIn recent years, technological advances in the field of diabetes have revolutionized the management, prognosis, and quality of life of diabetes patients and their environment. The aim of our study was to evaluate the impact of implementing the MiniMed 780G closed‐loop system in a pediatric and adolescent population previously treated with a continuous subcutaneous insulin infusion pump and intermittent glucose monitoring.MethodsData were collected from 28 patients with type 1 diabetes aged 6 to 17 years, with a follow‐up of 6 months. We included both glucometric and quality of life variables, as well as quality of life in primary caregivers. Metabolic control variables were assessed at baseline (before system change) and at different cutoff points after initiation of the closed‐loop system (48 hours, 7 days, 14 days, 21 days, 1 month, 3 months, 6 months).ResultsTime in range 70–180 mg/dL increased from 59.44% at baseline to 74.29% in the first 48 hours after automation of the new system, and this improvement was maintained at the other cutoff points, as was time in hyperglycemia 180–250 mg/dL (24.44% at baseline to 18.96% at 48 hours) and >250 mg/dL (11.71% at baseline to 3.82% at 48 hours).ConclusionsOur study showed an improvement in time in range and in all time spent in hyperglycemia from the first 48 hours after the automation of the system, which was maintained at 6 months.
High‐resolution peripheral quantitative computed tomography for the evaluation of bone erosions of metatarsophalangeal joints in patients with rheumatoid arthritis
Authors: Meinhardsson Jørgen Martin , Klose‐Jensen Rasmus , Therkildsen Josephine , Langdahl Bente , Hauge Ellen‐Margrethe , Keller Kresten Krarup 
Published: June 2023

AbstractObjectivesTo compare if the 4th and 5th metatarsophalangeal (MTP) joints evaluated by high‐resolution peripheral quantitative computed tomography (HR‐pQCT) could classify more patients with erosive rheumatoid arthritis (RA) compared with conventional radiography (CR) of the hands, wrists, and feet. Furthermore, we characterize and quantify bone erosions in the two MTP joints by HR‐pQCT.MethodsThis single‐center cross‐sectional study included patients with established RA (disease duration ≥5 years). Blinded to patient data, the number and volume of erosions in the 4th and 5th MTP joints were measured by HR‐pQCT, whereas the erosive scores by CR of 44 joints in the hands, wrists, and feet were assessed according to the Sharp/van der Heijde method.ResultsAmong 42 participants, 30 patients were classified with erosive RA and 12 with non‐erosive RA by CR. HR‐pQCT of two MTP joints could classify more patients with erosive RA compared with CR of 44 joints (p = .03). The optimal cut‐off value for the number and volume of erosions per patient in the 4th and 5th MTP joints by HR‐pQCT was 7.5 erosions and 11.7 mm3, respectively, for detecting erosive disease by CR. Erosions in the two MTP joints by HR‐pQCT were found most frequently and were largest at the lateral quadrant of the 5th metatarsal head.ConclusionThe superiority of HR‐pQCT of the 4th and 5th MTP joints compared with CR of 44 joints for classifying erosive RA provides a basis for larger studies evaluating if HR‐pQCT could be used for diagnosing erosive RA in the future.
Cancer development in patients hospitalized with systemic lupus erythematosus: A population‐level data linkage study
Authors: Raymond Warren David , Preen David Brian , Keen Helen Isobel , Inderjeeth Charles Anoopkumar , Nossent Johannes Cornelis 
Published: June 2023

AbstractAimTo explore the association between systemic lupus erythematosus (SLE) with the risk of cancer development and subsequent 5‐year mortality in Western Australia (WA).MethodsPopulation‐level, data linkage study of SLE patients (n = 2111) and general population comparators (n = 21 110) hospitalized between 1980 and 2014. SLE patients (identified by ICD‐9‐CM: 695.4, 710.0, and ICD‐10‐AM: L93.0, M32.0) were nearest matched (10:1) for age, sex, Aboriginality, and temporality. Follow up was from time zero (index SLE hospitalization) to cancer development, death or 31 December 2014. We assessed the risk of cancer development and subsequent 5‐year mortality between SLE patients and comparators with univariate and multivariate‐adjusted Cox proportional hazards regression models.ResultsSLE patients had similar multivariate‐adjusted risk (adjusted hazard ratio [aHR] 1.03, 95% confidence interval [CI] 0.93–1.15; p = .583) of cancer development. Cancer development risk was higher in SLE patients <40 years old (aHR 1.58, 95% CI 1.29–1.94; p < .001), and from 1980 to 1999 (aHR 1.16, 95% CI 1.02–1.31; p < .001). SLE patients had higher risk of developing cancer of the oropharynx (aHR 2.13, 95% CI 1.30–3.50), vulvo‐vagina (aHR 3.22, 95% CI 1.34–7.75), skin (aHR 1.20, 95% CI 1.01–1.43), musculoskeletal tissues (aHR 2.26, 95% CI 1.16–4.40), and hematological tissues (aHR 1.78 95% CI 1.25–2.53), all p < .05. After cancer development, SLE patients had increased risk of 5‐year mortality (aHR 1.31, 95% CI 1.06–1.61); highest in patients <50 years old (aHR 2.03, 95% CI 1.03–4.00), and in those with reproductive system and skin cancers.ConclusionsHospitalized SLE patients had increased risk of multiple cancer sub‐types. Following cancer development, SLE patients had increased risk of 5‐year mortality. There is scope to improve cancer prevention and surveillance in SLE patients.Trial registrationNot applicable. This low‐risk risk study used de‐identified administrative linked health data.
Acute myeloid leukemia and myelodysplastic syndrome associated with a combination of immune checkpoint inhibitor and platinum‐based chemotherapy
Authors: Nakatsuru Kousei , Tsubouchi Kazuya , Hirahata Minori , Nakashima Tadayuki , Takahata Yuriko , Okamatsu Yuki , Shiraishi Yoshimasa , Okamoto Isamu , Harada Taishi 
Published: June 2023

AbstractTherapy related‐acute myeloid leukemia (t‐AML) and myelodysplastic syndrome (t‐MDS) are complications of chemotherapy and/or radiation therapy for malignant diseases. In this report, we describe a patient with advanced lung adenocarcinoma who developed autoimmune hemolytic anemia and MDS associated with a combination of atezolizumab and platinum‐based chemotherapy. The patient showed progression from t‐MDS to t‐AML 20 months after the treatment was initiated. A combination of immune checkpoint inhibitor (ICI) and chemotherapy may increase the risk of developing therapy‐related myeloid neoplasms. As the prognosis of t‐AML and t‐MDS is poorer than that of de novo AML and MDS, proper surveillance, follow‐up, and treatment are needed throughout the course of immunotherapy.
The implications of firms' derivative usage on the frequency and usefulness of management earnings forecasts
Authors: Campbell John L. , Cao Sean Shun , Chang Hye Sun , Chiorean Raluca 
Published: June 2023

AbstractWe investigate how firms' use of derivatives impacts voluntary disclosure and offer four main findings. First, we find that when firms begin using derivative instruments, they increase the frequency of management earnings forecasts. Second, using path analysis, we find a direct link between derivative usage and forecast frequency, as well as an indirect link through reduced earnings volatility. Third, we find that CEOs with more pronounced career concerns increase forecast frequency only when derivatives make earnings easier to forecast and find no evidence that investor demand drives the decision to provide a forecast. These results suggest that the primary mechanism for the association between derivative usage and forecast frequency is a reduction in the manager's costs of providing the forecasts. Finally, we find that the majority of derivative‐induced forecasts are uninformative to capital market participants, especially after FAS 161 provided the necessary underlying data to understand how firms use derivatives. Overall, we provide the first empirical evidence that firms that use derivatives issue more management forecasts, but we also find that these incremental forecasts are largely uninformative and appear driven by managerial career concerns.
Multi‐animal‐model study reveals mutations in neural plasticity and nociception genes linked to excessive alcohol drinking
Authors: Muir William M. , Lo Chiao‐Ling , Bell Richard L. , Zhou Feng C. 
Published: June 2023

AbstractBackgroundThe basis for familial alcohol use disorder (AUD) remains an enigma due to various biological and societal confounds. The present study used three of the most adopted and documented rat models, combining the alcohol‐preferring/non‐alcohol‐preferring (P/NP) lines and high alcohol‐drinking/low alcohol‐drinking (HAD/LAD) replicated lines, of AUD as examined through the lens of whole genomic analyses.MethodsWe used complete genome sequencing of the P/NP lines and previously published sequences of the HAD/LAD replicates to enhance the discovery of variants associated with AUD and to remove confounding with genetic background and random genetic drift. Specifically, we used high‐order statistical methods to search for genetic variants whose frequency changes in whole sets of gene ontologies corresponded with phenotypic changes in the direction of selection, that is, ethanol‐drinking preference.ResultsOur first finding was that in addition to variants causing translational changes, the principal genetic changes associated with drinking predisposition were silent mutations and mutations in the 3′ untranslated regions (3′UTR) of genes. Neither of these types of mutations alters the amino acid sequence of the translated protein but they influence both the rate and conformation of gene transcription, including its stability and posttranslational events that alter gene efficacy. This finding argues for refocusing human genomic studies on changes in gene efficacy. Among the key ontologies identified were the central genes associated with the Na+ voltage–gated channels of neurons and glia (including the Scn1a, Scn2a, Scn2b, Scn3a, Scn7a, and Scn9a subtypes) and excitatory glutamatergic secretion (including Grm2 and Myo6), both of which are essential in neuroplasticity. In addition, we identified “Nociception or Sensory Perception of Pain,” which contained variants in nociception (Arrb1, Ccl3, Ephb1) and enlist sodium (Scn1a, Scn2a, Scn2b, Scn3a, Scn7a), pain activation (Scn9a), and potassium channel (Kcna1) genes.ConclusionThe multi‐model analyses used herein reduced the confounding effects of random drift and the “founders” genetic background. The most differentiated bidirectionally selected genes across all three animal models were Scn9a, Scn1a, and Kcna, all of which are annotated in the nociception ontology. The complexity of neuroplasticity and nociception adds strength to the hypothesis that neuroplasticity and pain (physical or psychological) are prominent phenotypes genetically linked to the development of AUD.
Risk of suicide attempt and suicide associated with benzodiazepine: A nationwide case crossover study
Authors: Tournier Marie , Bénard‐Laribière Anne , Jollant Fabrice , Hucteau Emilie , Diop Papa‐Yatma , Jarne‐Munoz Ana , Pariente Antoine , Oger Emmanuel , Bezin Julien 
Published: June 2023

AbstractBackgroundPrevious studies that found an association between benzodiazepines and suicidal behaviours were confounded by indication bias.AimsTo limit this bias, a case crossover study (CCO) was conducted to estimate the risk of suicide attempt and suicide associated with benzodiazepines.MethodPatients ≥16 years, with hospitalised suicide attempt or suicide between 2013 and 2016, and at least one benzodiazepine dispensing within the 120 days before their act were selected in the nationwide French reimbursement healthcare system databases (SNDS). For each patient, frequency of benzodiazepine dispensing was compared between a risk period (days −30 to −1 before the event) and two matched reference periods (days −120 to −91, and −90 to −61).ResultsA total of 111,550 individuals who attempted suicide and 12,312 suicide victims were included, of who, respectively, 77,474 and 7958 had recent psychiatric history. Benzodiazepine dispensing appeared higher in the 30‐day risk period than in reference ones. The comparison yielded adjusted odds ratios of 1.74 for hospitalised suicide attempt (95% confidence interval 1.69–1.78) and 1.45 for suicide (1.34–1.57) in individuals with recent psychiatric history, and of 2.77 (2.69–2.86) and 1.80 (1.65–1.97) for individuals without.ConclusionThis nationwide study supports an association between recent benzodiazepine use and both suicide attempt and suicide. These results strengthen the need for screening for suicidal risk carefully before initiation and during treatment when prescribing benzodiazepines. Registration No. EUPAS48070 (http://www.ENCEPP.eu).
Technology transmission in pre‐modern China: Evidence from a Chinese clan, 1400–1800
Authors: Wang Runnan 
Published: June 2023

AbstractThis study examines the intergenerational transmission of technology in historical China by constructing a genealogy dataset of the Huang family from 1400 to 1800. The family specialised in woodblock carving for book production, and their names were documented in these volumes, enabling measurement of technological output. Analysing 902 individuals across 16 generations reveals that carving skills were primarily transmitted from fathers to sons, with little influence from other family members or external artisans. Moreover, the production of books by the Huang family experienced a decline in the early 17th century, potentially attributed to weather shocks and decreased demand for books.
Genetic polymorphism and variability in the Guangdong Hakka, Teochew, and Cantonese groups: A comprehensive analysis of 19 X‐STRs
Authors: Xiao Cheng , Yang Xingyi , Yu Zhonghao , Wu Weibin , Wang Yuan , Xu Quyi , Chen Ling 
Published: June 2023

AbstractBackgroundX chromosomeshort tandem repeat (X‐STR) loci are playing an increasingly important role inforensic work, identifying female traces in male contamination and explainingcomplex kinship analyses.MethodsIn this study, we analyzed thegenetic polymorphism of 19 X‐STR loci in the Guangdong Hakka, Teochew and Cantonese groups, respectively, aswell as in the Guangdong Hakka, Teochew andCantonese pooled Han. The genetic diversity and forensic characteristics of the19 X‐STRs and 7 linkage groups were investigated, respectively.ResultsThe experiments showed that the genetic diversity (GD) and polymorphism information content (PIC) in the pooledGuangdong Han ranged from 0.5320 to 0.9234 and 0.4369 to 0.9171, respectively, and the cumulative power of discrimination for males (PDM), power of discrimination for females (PDF) and mean paternity exclusion chance (MEC) were higher than 0.9999999, indicating that the 19 X‐STRs had high geneticpolymorphism and discriminatory power. Genetic differences among Chinese Hansubgroups and among different Chinese populations were investigated byphylogenetic reconstruction and principal component analysis (PCA), respectively. Genetic analyses based on neighbor‐joining (NJ) tree and principal component analysis plot showed that Cantonese, Teochew and Hakka were closely genetically related, and different populations with closer linguistic components had more genetic affinity.ConclusionsThis study adds to the forensic X‐STR database and demonstrates the forensic efficiency of 19 X‐STRs for the Hakka, Teochewand Cantonese populations in Guangdong, and the pooled Han of Hakka, Teochewand Cantonese people in Guangdong.
Promoter region variant C‐824T in the TH gene modulates the subjective effects of cocaine
Authors: Bolin Peter K. , Nielsen Ellen M. , Nielsen David A. , De La Garza Richard 
Published: June 2023

AbstractBackground and ObjectivesThis study examined how a promoter variant of TH (rs10770141) affects subjective effects of cocaine in 65 nontreatment‐seeking individuals with cocaine dependence.MethodsParticipants received cocaine/saline intravenously, and TH genotypes were evaluated.ResultsHomozygous individuals for the minor T allele reported greater “good” and “bad” subjective effects to cocaine than those with the major C allele.Discussion and ConclusionsTH rs10770141 modulates subjective effects of cocaine in participants with cocaine dependence.Scientific SignificanceThese results are among the first to indicate that homozygosity of the T allele of rs10770141 modulates greater sensitivity to cocaine.
Timing of elective surgery and risk assessment after SARS‐CoV‐2 infection: 2023 update
Authors: El‐Boghdadly K. , Cook T. M. , Goodacre T. , Kua J. , Denmark S. , Mercer N. , Moonesinghe S. R. , Summerton D. J. 
Published: June 2023

SummaryGuidance for the timing of surgery following SARS‐CoV‐2 infection needed reassessment given widespread vaccination, less virulent variants, contemporary evidence and a need to increase access to safe surgery. We, therefore, updated previous recommendations to assist policymakers, administrative staff, clinicians and, most importantly, patients. Patients who develop symptoms of SARS‐CoV‐2 infection within 7 weeks of planned surgery, including on the day of surgery, should be screened for SARS‐CoV‐2. Elective surgery should not usually be undertaken within 2 weeks of diagnosis of SARS‐CoV‐2 infection. For patients who have recovered from SARS‐CoV‐2 infection and who are low risk or having low‐risk surgery, most elective surgery can proceed 2 weeks following a SARS‐CoV‐2 positive test. For patients who are not low risk or having anything other than low‐risk surgery between 2 and 7 weeks following infection, an individual risk assessment must be performed. This should consider: patient factors (age; comorbid and functional status); infection factors (severity; ongoing symptoms; vaccination); and surgical factors (clinical priority; risk of disease progression; grade of surgery). This assessment should include the use of an objective and validated risk prediction tool and shared decision‐making, taking into account the patient's own attitude to risk. In most circumstances, surgery should proceed unless risk assessment indicates that the risk of proceeding exceeds the risk of delay. There is currently no evidence to support delaying surgery beyond 7 weeks for patients who have fully recovered from or have had mild SARS‐CoV‐2 infection.
Flame thrower
Authors: Vidali Debra 
Published: June 2023

SummaryThis poem is part of a special section in honor of Kathleen Stewart. Imagined as a staccato spoken word piece, the short lines with visual semantic and sonic parallelisms flow like an urgent, nonstop process of throwing flames, barbs, disruptions, and unexpected care into anthropological spaces. As such, the poetic layout pays tribute with an itemized list of Katie's interventions: surgical strikes, sharp, powerful presences, and gentle lyric clarity.
Rationality of FIGO 2018 IIIC restaging of cervical cancer according to local tumor size: A cohort study
Authors: Duan Hui , Li Huimin , Kang Shan , Zhao Hongwei , Chen Biliang , Wang Li , Li Pengfei , Wang Yahong , Wang Wei , Lang Jinghe , Liu Ping , Chen Chunlin 
Published: June 2023

AbstractIntroductionFIGO 2018 IIIC remains controversial for the heterogeneity of its prognoses. To ensure a better management of cervical cancer patients in Stage IIIC, a revision of the FIGO IIIC version classification is required according to local tumor size.Material and methodsWe retrospectively enrolled cervical cancer patients of FIGO 2018 Stages I–IIIC who had undergone radical surgery or chemoradiotherapy. Based on the tumor factors from the Tumor Node Metastasis staging system, IIIC cases were divided into IIIC‐T1, IIIC‐T2a, IIIC‐T2b, and IIIC‐(T3a+T3b). Oncologcial outcomes of all stages were compared.ResultsA total of 63 926 cervical cancer cases were identified, among which 9452 fulfilled the inclusion criteria and were included in this study. Kaplan–Meier pairwise analysis showed that: the oncology outcomes of I and IIA were significantly better than of IIB, IIIA+IIIB, and IIIC; the oncology outcome of IIIC‐(T1‐T2b) was significantly better than of IIIA+IIIB and IIIC‐(T3a+T3b); no significant difference was noted between IIB and IIIC‐(T1‐T2b), or IIIC‐(T3a+T3b) and IIIA+IIIB. Multivariate analysis indicated that, compared with IIIC‐T1, Stages T2a, T2b, IIIA+IIIB and IIIC‐(T3a+T3b) were associated with a higher risk of death and recurrence/death. There was no significant difference in the risk of death or recurrence/death between patients with IIIC‐(T1‐T2b) and IIB. Also, compared with IIB, IIIC‐(T3a+T3b) was associated with a higher risk of death and recurrence/death. No significant differences in the risk of death and recurrence/death were noted between IIIC‐(T3a+T3b) and IIIA+IIIB.ConclusionsIn terms of oncology outcomes of the study, FIGO 2018 Stage IIIC of cervical cancer is unreasonable. Stages IIIC‐T1, T2a, and T2b may be integrated as IIC, and it might be unnecessary for T3a/T3b cases to be subdivided by lymph node status.
Symptoms mediate the relationship between childhood trauma and non‐suicidal self‐injury: A hospital‐based study of adolescents with mood disorder
Authors: Zhou Rui , Ji Ting , Zhang Ji‐Jie , Liu Yin‐Du , Wang Fei , Jia Fu‐Jun , Hou Cai‐Lan 
Published: June 2023

AbstractBackgroundChildhood trauma has a significant impact on the development of adolescents, which may lead to interpersonal and psychological problems. Determining the incidence and consequences of childhood trauma in psychiatric clinical practice is of great significance.MethodsA survey was conducted among adolescents with mood disorders. Childhood Trauma Questionnaire (CTQ), the Adolescent Non‐Suicidal‐Self‐Injury Behavior Function Assessment Scale (ANBFAS) and a series of psychological scales were filled face to face. Path analysis was used to examine the causation structure of childhood trauma‐related symptoms.ResultsA total of 117 participants (74.5%) had experienced at least one type of trauma. Interpersonal and psychological features of adolescent patients with childhood trauma were detailed in this study. The path analysis model showed that the relationships between childhood trauma and NSSI were mediated by depressive symptoms and thinking disorders, respectively, whereas depressive symptoms individually mediated the correlation between childhood trauma and sleep disturbances in adolescent patients with psychiatric disorders (χ2/df = 1.23).ConclusionFor adolescent patients with childhood trauma, psychological counseling for interpersonal relationships should start with families and peers. It is important to treat their depressive symptoms and thinking disorders and alleviate NSSI behavior and sleep disorders.