bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic Value of Circulating miR-29 Family for Digestive System Malignancies: A Meta-Analysis
Authors: Zou Shuhui , Chen Fei , Zhang Liqin , Liu Cong , Chen Huamin 
Published: May 2023

Abstract

Objective
To evaluate the diagnostic value of circulating microRNA-29 (miR-29) in digestive system malignant neoplasms by meta-analysis.

Methods
We searched the PubMed, Embase, Cochrane Library, and Web of Science to collect studies, published through September 2022, on the diagnostic value of miR-29 in digestive system tumors.

Results
We included 7 studies in this meta-analysis, including colorectal cancer, esophageal squamous cell carcinomas, and cholangiocarcinoma. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 0.64 (95% CI, 0.53–0.74), 0.83 (0.60–0.94), 3.75 (1.42–9.91), 0.44 (0.31–0.61), and 8.63 (2.54–29.26), respectively. The area under the summary receiver operating characteristic curve was 0.75. The sensitivity of miR-29 derived from serum was higher than that of miR-29 derived from plasma for malignant digestive system tumors (0.71 vs 0.54; P = .04).

Conclusion
This meta-analysis suggests that the circulating miR-29 family has good diagnostic performance for digestive system malignant tumors, with moderate sensitivity and good specificity.
Active galactic nucleus jet feedback in hydrostatic haloes
Authors: Weinberger Rainer , Su Kung-Yi , Ehlert Kristian , Pfrommer Christoph , Hernquist Lars , Bryan Greg L , Springel Volker , Li Yuan , Burkhart Blakesley , Choi Ena , Faucher-Giguère Claude-André 
Published: May 2023

ABSTRACT
Feedback driven by jets from active galactic nuclei is believed to be responsible for reducing cooling flows in cool-core galaxy clusters. We use simulations to model feedback from hydrodynamic jets in isolated haloes. While the jet propagation converges only after the diameter of the jet is well resolved, reliable predictions about the effects these jets have on the cooling time distribution function only require resolutions sufficient to keep the jet-inflated cavities stable. Comparing different model variations, as well as an independent jet model using a different hydrodynamics code, we show that the dominant uncertainties are the choices of jet properties within a given model. Independent of implementation, we find that light, thermal jets with low momentum flux tend to delay the onset of a cooling flow more efficiently on a 50 Myr time-scale than heavy, kinetic jets. The delay of the cooling flow originates from a displacement and boost in entropy of the central gas. If the jet kinetic luminosity depends on accretion rate, collimated, light, hydrodynamic jets are able to reduce cooling flows in haloes, without a need for jet precession or wide opening angles. Comparing the jet feedback with a ‘kinetic wind’ implementation shows that equal amounts of star formation rate reduction can be achieved by different interactions with the halo gas: the jet has a larger effect on the hot halo gas while leaving the denser, star-forming phase in place, while the wind acts more locally on the star-forming phase, which manifests itself in different time-variability properties.
The role of the drag force in the gravitational stability of dusty planet-forming disc – II. Numerical simulations
Authors: Longarini Cristiano , Armitage Philip J , Lodato Giuseppe , Price Daniel J , Ceppi Simone 
Published: May 2023

ABSTRACT
Young protostellar discs are likely to be both self-gravitating, and to support grain growth to sizes where the particles decoupled from the gas. This combination could lead to short-wavelength fragmentation of the solid component in otherwise non-fragmenting gas discs, forming Earth-mass solid cores during the Class 0/I stages of young stellar object evolution. We use three-dimensional smoothed particle hydrodynamics simulations of two-fluid discs, in the regime where the Stokes number of the particles St &gt; 1, to study how the formation of solid clumps depends on the disc-to-star mass ratio, the strength of gravitational instability, and the Stokes number. Gravitational instability of the simulated discs is sustained by local cooling. We find that the ability of the spiral structures to concentrate solids increases with the cooling time and decreases with the Stokes number, while the relative dynamical temperature between gas and dust of the particles decreases with the cooling time and the disc-to-star mass ratio and increases with the Stokes number. Dust collapse occurs in a subset of high disc mass simulations, yielding clumps whose mass is close to linear theory estimates, namely 1–10 M⊕. Our results suggest that if planet formation occurs via this mechanism, the best conditions correspond to near the end of the self-gravitating phase, when the cooling time is long and the Stokes number close to unity.
Conservation of the Restricted Expression of Brassicaceae Bsister-Like Genes in Seeds Requires a Transposable Element in Arabidopsis thaliana
Authors: Roessner Clemens , Bhide Amey S , Hoffmeier Andrea , Schenk Julian , Groß Thomas , Gramzow Lydia , Theißen Günter , Becker Annette 
Published: May 2023

Abstract
Changes in transcription factor binding sites (TFBSs) can alter the spatiotemporal expression pattern and transcript abundance of genes. Loss and gain of TFBSs were shown to cause shifts in expression patterns in numerous cases. However, we know little about the evolution of extended regulatory sequences incorporating many TFBSs. We compare, across the crucifers (Brassicaceae, cabbage family), the sequences between the translated regions of Arabidopsis Bsister (ABS)-like MADS-box genes (including paralogous GOA-like genes) and the next gene upstream, as an example of family-wide evolution of putative upstream regulatory regions (PURRs). ABS-like genes are essential for integument development of ovules and endothelium formation in seeds of Arabidopsis thaliana. A combination of motif-based gene ontology enrichment and reporter gene analysis using A. thaliana as common trans-regulatory environment allows analysis of selected Brassicaceae Bsister gene PURRs. Comparison of TFBS of transcriptionally active ABS-like genes with those of transcriptionally largely inactive GOA-like genes shows that the number of in silico predicted TFBS) is similar between paralogs, emphasizing the importance of experimental verification for in silico characterization of TFBS activity and analysis of their evolution. Further, our data show highly conserved expression of Brassicaceae ABS-like genes almost exclusively in the chalazal region of ovules. The Arabidopsis-specific insertion of a transposable element (TE) into the ABS PURRs is required for stabilizing this spatially restricted expression, while other Brassicaceae achieve chalaza-specific expression without TE insertion. We hypothesize that the chalaza-specific expression of ABS is regulated by cis-regulatory elements provided by the TE.
Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction
Authors: Wang Tzu-Fei , Khorana Alok A , Agnelli Giancarlo , Bloomfield Dan , Bonaca Marc P , Büller Harry R , Connors Jean M , Goto Shinya , Jing Zhi-Cheng , Kakkar Ajay K , Khder Yasser , Raskob Gary E , Soff Gerald A , Verhamme Peter , Weitz Jeffrey I , Carrier Marc 
Published: May 2023

Abstract
Cancer-associated thrombosis, with the incidence rising over the years, is associated with significant morbidity and mortality in patients with cancer. Recent advances in the treatment of cancer-associated venous thromboembolism (VTE) include the introduction of direct oral anticoagulants (DOACs), which provide a more convenient and effective option than low-molecular-weight heparin (LMWH). Nonetheless, important unmet needs remain including an increased risk of bleeding in certain patient subgroups such as those with gastroesophageal cancer, concerns about drug-drug interactions, and management of patients with severe renal impairment. Although DOACs are more convenient than LMWH, persistence can decline over time. Factor XI inhibitors have potential safety advantages over DOACs because factor XI appears to be essential for thrombosis but not hemostasis. In phase II trials, some factor XI inhibitors were superior to enoxaparin for the prevention of VTE after knee replacement surgery without increasing the risk of bleeding. Ongoing trials are assessing the efficacy and safety of factor XI inhibitors for the treatment of cancer-associated VTE.
The missing links of research impact
Authors: Budtz Pedersen David , Hvidtfeldt Rolf 
Published: May 2023

Abstract
In this article, we present a conceptual framework for studying research impact focusing on the foundations that need to be in place to accelerate an observable change of policy, practice or behaviour. The article investigates the relationship between micro-impacts and societal change, and how smaller impacts scale into larger cascades of end effects and value creation. We define micro-impacts as interactions and connections where information is exchanged between a researcher or research group and external audiences, stakeholders or co-producers. Micro-impacts are elements in highly complex causal relations between research activities and larger societal macroshifts. We argue that even though these causal relations are complex, micro-impacts are tangible and observable and should be integrated in research evaluations as constitutive elements of causal impact relations leading to larger macroshifts. We suggest a working model for studying micro-impacts and for reflecting on the causality of impacts by drawing on contributions from philosophy of causation. A proper understanding of causation is a prerequisite for eventually understanding and capturing research impact, which itself is a prerequisite for responsible research assessment and planning.
Suicidal Ideation and Non-Suicidal Self-Injury Following Early Childhood Psychotic Experiences in Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder—The Danish High Risk and Resilience Study, VIA 11
Authors: Gregersen Maja , Møllegaard Jepsen Jens Richardt , Marie Brandt Julie , Søndergaard Anne , Birkehøj Rohd Sinnika , Veddum Lotte , Bruun Knudsen Christina , Krogh Andreassen Anna , Klee Burton Birgitte , Hjorthøj Carsten , Falkenberg Krantz Mette , Neergaard Greve Aja , Bliksted Vibeke , Mors Ole , Nordentoft Merete , Elgaard Thorup Anne Amalie , Hemager Nicoline 
Published: May 2023

Abstract

Background and Hypothesis
Suicide is a leading cause of death in youth and is often preceded by suicidal ideation (SI) and non-suicidal self-injury (NSSI). Identifying early markers of risk for SI and NSSI could improve timely identification of at-risk individuals.

Study Design
Children (mean age 11.9, SD 0.2) at familial high risk of schizophrenia (N = 171), or bipolar disorder (N = 104), and controls (N = 174) were assessed for psychotic experiences (PE), SI, NSSI, and Axis I mental disorders in face-to-face interviews in early and middle childhood (age 7 and 11).

Study Results
Having 2 types of early childhood PE predicted middle childhood SI after accounting for previous SI, NSSI, and mental disorders (OR 2.8, 95% CI 1.1–6.9; P = .03). Two PE predicted NSSI (OR 3.0, 95% CI 1.2–7.7; P = .02) in excess of previous SI, NSSI, mental disorders, and familial risk. Persistent and incident PE predicted SI (OR 3.2, 95% CI, 1.1–8.8; P = .03; OR 3.8, 95% CI, 1.3–11.5; P = .02) in the fully adjusted model. Nineteen percent of children with persistent PE reported middle childhood SI vs 3.8% of those who never reported PE. In children with early childhood mental disorders, those who reported 2 PE had 4.4-fold increased odds of later SI (95% CI, 1.2–16.7; P = .03) after adjustments. PE were nondifferentially associated with outcomes across familial risk groups.

Conclusions
Early childhood PE index elevated risk for subsequent SI and NSSI beyond what can be attributed to presence of mental disorders. Mental health screenings and clinical assessments should include early childhood PE.
A review of the psychosocial factors that contribute to sexuality, female sexual dysfunction, and sexual pain among Muslim women
Authors: Lamba Arleen , Mohajir Nadiah , Rahman Sameena 
Published: May 2023

AbstractIntroductionSexual pain disorders are complex conditions experienced by women around the world. Muslim women experience sexuality and sexual dysfunction in a distinct manner that is influenced by religious and cultural standards. Muslim women experiencing sexual pain are a unique patient population whose cultural background should be understood by health care professionals to provide culturally competent care.ObjectivesTo identify the psychosocial factors that influence Muslim women’s experience of sexual pain.MethodsA comprehensive review of the literature through PubMed and Google Scholar was conducted to compile information related to sexual dysfunction, sexual pain, and treatment options in the Muslim women population in the United States and internationally.ResultsPainful sex among Muslim women has been associated with female genital cutting, cultural taboos, lack of sex education, absence of language to discuss sex, negative cognitions about sex, expectations to bear the male partner’s inconsiderate sexual performance, and familial interference. Typical treatments for sexual pain in Islamic countries were explored, with new treatments that have recently been tested.ConclusionUnderstanding sexual pain among Muslim women, including the religious and cultural factors that are potentially associated with this pain, is important for health care professionals to care for their Muslim patients in a culturally competent manner and reduce the implicit bias that may affect quality of care. It appears that providing sexual education, with treatment modalities such as psychotherapy and physical therapy, is useful in treating female sexual pain. We suggest that sexual education, as well as a cultural shift that embraces women’s sexual agency, is needed to reduce and prevent sexual pain.
ETS2 promotes cardiomyocyte apoptosis and autophagy in heart failure by regulating lncRNA TUG1/miR‐129‐5p/ATG7 axis
Authors: Tan Li , Xiong Di , Zhang Hui , Xiao Sirou , Yi Ruilan , Wu Jian 
Published: May 2023

AbstractHeart failure (HF) is a chronic disease in which the heart is unable to provide enough blood and oxygen to the peripheral tissues. Cardiomyocyte apoptosis and autophagy have been linked to HF progression. However, the underlying mechanism of HF is unknown. In this study, H2O2‐treated AC16 cells were used as a cell model of HF. The mRNA and protein levels of related genes were examined using RT‐qPCR and western blot. Cell viability and apoptosis were assessed using CCK‐8 and flow cytometry, respectively. The interactions between ETS2, TUG1, miR‐129‐5p, and ATG7 were validated by luciferase activity, ChIP, and RNA‐Binding protein Immunoprecipitation assays. According to our findings, H2O2stimulation increased the expression of ETS2, TUG1, and ATG7 while decreasing the expression of miR‐129‐5p in AC16 cells. Furthermore, H2O2stimulation induced cardiomyocyte apoptosis and autophagy, which were reversed by ETS2 depletion, TUG1 silencing, or miR‐129‐5p upregulation. Mechanistically, ETS2 promoted TUG1 expression by binding to the TUG1 promoter, and TUG1 sponged miR‐129‐5p to increase ATG7 expression. Furthermore, TUG1 overexpression reversed ETS2 knockdown‐mediated inhibition of cardiomyocyte apoptosis and autophagy and miR‐129‐5p inhibition abolished TUG1 depletion‐mediated suppression of cardiomyocyte apoptosis and autophagy in H2O2‐induced AC16 cells. As presumed, ATG7 overexpression reversed miR‐129‐5p mimics‐mediated repression of cardiomyocyte apoptosis and autophagy in H2O2‐induced AC16 cells. Finally, ETS2 silencing reduced cardiomyocyte apoptosis and autophagy to slow HF progression by targeting the ETS2/TUG1/miR‐129‐5p/ATG7 axis, which may provide new therapeutic targets for HF treatment.
USP25 contributes to defective neurogenesis and cognitive impairments
Authors: Cai Fang , Song Beibei , Yang Yi , Liao Haikang , Li Ran , Wang Zhao , Cao Ruixue , Chen Huaqiu , Wang Juelu , Wu Yili , Zhang Yun , Song Weihong 
Published: May 2023

AbstractBoth Down syndrome (DS) individuals and animal models exhibit hypo‐cellularity in hippocampus and neocortex indicated by enhanced neuronal death and compromised neurogenesis. Ubiquitin‐specific peptidase 25 (USP25), a human chromosome 21 (HSA21) gene, encodes for a deubiquitinating enzyme overexpressed in DS patients. Dysregulation of USP25 has been associated with Alzheimer's phenotypes in DS, but its role in defective neurogenesis in DS has not been defined. In this study, we found that USP25 upregulation impaired cell cycle regulation during embryonic neurogenesis and cortical development. Overexpression of USP25 in hippocampus promoted the neural stem cells to glial cell fates and suppressed neuronal cell fate by altering the balance between cyclin D1 and cyclin D2, thus reducing neurogenesis in the hippocampus. USP25‐Tg mice showed increased anxiety/depression‐like behaviors and learning and memory deficits. These results suggested that USP25 overexpression resulted in defective neurogenesis and cognitive impairments, which could contribute to the pathogenesis of DS. USP25 may be a potential pharmaceutical target for DS.
The Protective Effectiveness of 2-Dose Varicella Vaccination in Children in Korea: A Case-control Study
Authors: Lee Young Hwa , Choe Young June , Hong Kwan , Yoon Yoonsun , Kim Yun-Kyung 
Published: May 2023

Background:
A 2-dose vaccination against varicella has been adopted in many places; however, it has not been widely introduced in Korea. This study aimed to assess 1-dose and 2-+dose vaccine effectiveness (VE) against laboratory-confirmed varicella in Korea to provide a scientific basis for developing an immunization strategy.

Methods:
We constructed a national cohort using national surveillance data and the national immunization registry. From the cohort, we conducted a 1:2 matched nested case-control study to estimate and compare the VE of the 1-dose and 2-dose of varicella vaccination using exact conditional logistic regression. VE was calculated as [1 − matched odds ratio (OR) × 100%].

Results:
From January 1, 2011 to December 31, 2020, a total of 205,173 varicella cases were reported to the notifiable diseases surveillance system. Of these, we included 4,387 laboratory-confirmed varicella cases and 8,774 controls for the analyses. The VE of 1-dose vaccination was 16.8% (95% CI: −9.0% to 36.5%), whereas the VE of 2-doses of the vaccination was 98.6% (95% CI: 96.0%–99.5%).

Conclusion:
These findings suggest that the 2-dose vaccination strategy can be an effective strategy to prevent varicella.
Association Between Heavy Metals Exposure and Height in Chinese Preschoolers
Authors: Li Mingzhu , Ji Hongxian , Liu Yanli , Fu Ye , Lin Wei , Zhu Meiqin , Xie Duoshuang , Ding Hongcheng , Wang Jing 
Published: May 2023

Objectives
This study aimed to explore the association between multiple metals' exposure and children's height.

Methods
We collected urine samples and physical measurement data of 1477 preschoolers in China. Children's actual height was measured, and whether reached target height was also assessed. Logistic regression analysis was performed to explore the association between heavy metals and height. The least absolute shrinkage and selection operator regression was used to select the urinary metals, which were highly correlated.

Results
In the single-metal model after adjusting for potential confounders, urinary iron, aluminum, nickel, chrome, titanium, vanadium, selenium, rubidium, and thallium levels were negatively associated with actual height. Urinary iron, aluminum, nickel, and chrome concentrations were also negatively associated with target height.

Conclusions
The findings suggested that some urinary metal exposure might be associated with height in preschoolers.
Human descending aorta injury caused by brucellosis: A case report
Authors: Li Xiao , Sun Xiwei , Zhang Yang , Luo Sean X. , Yin Hang , Zhang Hua , Wang Zhongying , Cheng Zhihua 
Published: May 2023

Background:
Brucellosis is one of the most common zoonotic diseases in the world. Although cardiovascular complications of human brucellosis account for only 3% of morbidity, they are the leading cause of death. Peripheral vascular disease due to brucellosis is rare and under-reported in the literature.

Case presentation:
Two patients with previous brucellosis, both of whom had been treated with anti-brucellosis, were admitted to vascular surgery for thoracic aortic ulcer and abdominal aortic pseudoaneurysm, respectively, with positive IgG antibody to brucellosis and negative IgM antibody to brucellosis, tube agglutination test, and blood culture. These 2 patients were successfully treated with aortic stent-graft implantation and followed up for 8 and 10 weeks without complications.

Conclusions:
Chronic damage to human blood vessels by brucellosis may not disappear with brucellosis treatment, and peripheral blood vessels should be examined annually in people previously diagnosed with brucellosis. Clinicians in related departments should pay attention to peripheral vascular complications of brucellosis.
Clinical study of rhGM-CSF for the treatment of pulmonary exogenous acute respiratory distress syndrome by modulating alveolar macrophage subtypes: A randomized controlled trial
Authors: Sun Jie , Zhang Xiaokun , Ma Liliang , Yang Yong , Li Xia 
Published: May 2023

Background:
By modulating the oxygen partial pressure of alveolar epithelial cells, the granulocyte-macrophage colony-stimulating factor (GM-CSF) can stimulate and enhance the innate immune response in the lungs. This study aimed to investigate the therapeutic efficacy of rhGM-CSF in patients suffering from extrapulmonary-induced acute respiratory distress syndrome (ARDS).

Methods:
A randomized, double-blind, placebo-controlled clinical trial was conducted between February 2018 to July 2019, in which 66 sepsis patients with ARDS were recruited. The study randomly allocated the patients into 2 groups: an experimental group (34 cases receiving rhGM-CSF) and a control group (32 cases receiving placebo). The changes in lung function were assessed using the scores of PaO2/FIO2 ratio, acute physiology and chronic health evaluation II, sequential organ failure assessment, and lung injury. Additionally, the study analyzed the levels of inflammatory cells, HLA-DR (%), high mobility group protein B1 (HMGB-1) (ng/mL), tumor necrosis factor-alpha (pg/mL), IL-6 (pg/mL), and GM-CSF (pg/mL) in both blood and bronchoalveolar lavage fluid.

Results:
The study results revealed that the experimental group significantly enhanced their pulmonary function compared to the control group. Moreover, the experimental group demonstrated higher levels of inflammatory cells and HLA-DR, whereas levels of HMGB-1 and tumor necrosis factor-alpha were lower in blood (P < .05, respectively). In addition, the experimental group displayed a higher alternatively activated cell ratio and GM-CSF levels in bronchoalveolar lavage fluid (both P < .05); while HMGB-1 levels were significantly reduced (P < .05). However, no notable difference observed in mortality between the 2 groups (P > .05).

Conclusions:
Administering rhGM-CSF to ARDS patients improves lung function and decreases blood inflammation. Nonetheless, while this treatment demonstrates efficacy in reducing these parameters, it does not significantly impact the incidence of ventilator-associated pneumonia or 28-day mortality in ARDS patients.