bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic metastases in patients with neuroendocrine neoplasms: A multi‐centre cohort study
Authors: Tsoli Marina , Daskalakis Kosmas , Wedin Maria , Angelousi Anna , Povlsen Sebastian , Srirajaskanthan Raj , Giovos George , Weickert Martin O. , Kogut Angelika , Kos‐Kudla Beata , Oleinikov Kira , Grozinsky‐Glasberg Simona , Kaltsas Gregory 
Published: March 2023

AbstractPancreatic metastases (PMs) from neuroendocrine neoplasms (NENs) are rare but the increased sensitivity of new diagnostic tools such as 68Ga‐DOTATATE PET/CT has resulted in their increased recognition at initial diagnosis or follow‐up. A retrospective analysis of the data of patients from six tertiary referral centres was performed in order to identify the characteristics and the prognostic significance of PMs in patients with NENs. We used a control group of 69 age‐, sex‐ and primary tumour – matched NEN patients from the same cohort with stage IV disease but no PMs. Overall survival (OS) was assessed using the Kaplan–Meier method log‐rank analysis was used to assess the impact of various clinical and histopathological variables in OS. We identified 25 patients (11 females) with PMs with a median age at diagnosis of 60 years. The small intestine was the most common primary (80%) with a prevalence of 4.2% PMs (21/506). Fourteen patients presented with synchronous PMs whereas 11 developed metachronous PMs after a median time of 28 months (range: 7–168 months). Grading was available in 24 patients; 16 patients had G1 tumours, four G2, two atypical lung carcinoid, one typical and one atypical thymic carcinoid. Most patients had other concomitant metastases (12 hepatic, 4 lung and 6 bone) while five patients exhibited peritoneal carcinomatosis. Median OS in the PMs group was not reached compared with 212 months in the control group (95% CI: 26–398). The univariate analysis identified no prognostic factors statistically significantly associated with the OS. In conclusion, PMs are encountered with a low prevalence among NEN patients mostly developing in patients with advanced metastatic disease. The presence of PMs does not seem to be associated with a negative prognostic impact in OS.
Digital optimization of teeth setup in an edentulous patient with partial glossectomy: A case report
Authors: Carrière Mathieu , Prudentos Jean‐Baptiste , Lecigne Aude , Laran Adrien , Nguyen Caroline T. , Destruhaut Florent , Naveau Adrien 
Published: March 2023

AbstractThe purpose of this clinical report was to describe the use of a piezographic impression associated with computer‐aided design and computer‐aided manufacturing (CAD–CAM) for teeth setup and of digital tools for neuro‐musculo–kinetic analyses. An edentulous patient with hemiglossectomy and heavily resorbed mandible consulted for complete denture rehabilitation to improve their masticatory function and speech. Master casts, wax rims, and piezographic impression were scanned for digital prosthetic work. Two digital try‐ins were performed to respect the neutral zone: try‐in 1 with posterior crossbite and try‐in 2 without crossbite. Muscle activity and mandibular kinetics were performed for each try‐in following the MAC2 protocol (six criteria): muscular tone, contraction synchrony, contraction efficiency, interocclusal rest distance, amplitude of mandibular movement, and velocity. Try‐in 2 showed better data than try‐in 1 in all criteria: muscle tone (respectively 71% vs. 59%), contraction synchrony (79% vs. 75%), contraction efficiency (85% vs. 77%), an increase in range of motion of 3.3 mm, and a better velocity (0.35 ± 0.12 s vs. 0.57 ± 0.14 s, p = 0.008). The piezographic impression, in combination with CAD–CAM, allowed the comparison of two prosthetic designs and the selection of the try‐in with the best neuro‐musculo–kinetic results.
A re‐examination of the plant variety act 2021 from the perspective of pre‐exisiting obligation to protect plant varieties
Authors: Fapetu Oluwaseun S. 
Published: March 2023

AbstractThe paper examines the newly enacted Plant Variety Act in Nigeria in relation to the obligations of Nigeria to protect plant varieties. The paper views these obligations from different perspectives in the protection of diverse interest related to plant varieties. The paper finds that the Act offers an unbalanced protection of right which strongly protects the intellectual property rights of breeders without recourse to the other interest obligated to be protected by several international agreement which Nigeria is a signatory to especially farmers', communities and biodiversity interests. The paper advocates for an amendment of the Act to ensure a balanced and compliant legal framework for the protection of plant varieties in Nigeria.
Short‐ and Medium‐Term Effects of Parental Separation on Children's Well‐Being: Evidence from Uruguay
Authors: Bucheli Marisa , Vigorito Andrea 
Published: March 2023

AbstractThere is limited quantitative research on the effect of parental union dissolution on children's well‐being in developing countries. We use three waves of an Uruguayan longitudinal study that follows a cohort of first graders at public primary schools in 2004 to study the short‐term (at age 13) and medium‐term (at age 19) effects of parental separation on school attendance, grade repetition, completed years of schooling, socioemotional status, time devoted to a broad range of activities, and labor force participation. We carry out a difference‐in‐difference fixed‐effects estimation comparing children of married or cohabiting couples that remained together versus a similar group of children whose parents separated after 2004. In contrast to studies for developed countries, socioemotional well‐being remains unchanged. However, union dissolution worsens boys' educational outcomes in the short and medium term, whereas girls are only affected in the short term. Since lower educational attainment is difficult to reverse, it can result in reduced earnings during adulthood and in this way contribute to the intergenerational transmission of disadvantages. We also explore a set of potential moderators, including household income, maternal employment, access to durable goods, and public transfers, which suggest that worsened educational outcomes are closely connected to post‐separation economic hardship.
Impact of trained volunteers' services in caring for older persons with dementia: a systematic review
Authors: Handajani Yvonne Suzy , Aryani Astria , Schröder‐Butterfill Elisabeth , Turana Yuda 
Published: March 2023

AbstractDementia causes a great burden of disease globally. Volunteers' contributions in caring for older persons with dementia (OPD) are growing. This review aims to evaluate the impact of trained volunteers' involvement in providing care and support for OPD. PubMed, ProQuest, EBSCOHost, and Cochrane Library databases were searched using specific keywords. Inclusion criteria were studies of OPD who received interventions delivered by trained volunteers, which were published between 2018 and 2023. Seven studies were included in the final systematic review, comprising studies using quantitative and qualitative approaches. A wide range of outcomes was seen in both acute and home/community‐based care settings. Improvements in social interaction, loneliness, mood, ability to recall, and physical activity of OPD were found. Carers and trained volunteers were also found to benefit. Trained volunteers' involvement in OPD care plays a very valuable role for OPD, their caregivers, the volunteers, and in turn to society. This review also emphasizes the importance of person‐centred care for OPD.
Perception of self‐generated and externally‐generated visual stimuli: Evidence from EEG and behavior
Authors: Ody Edward , Straube Benjamin , He Yifei , Kircher Tilo 
Published: March 2023

AbstractEfference copy‐based forward model mechanisms may help us to distinguish between self‐generated and externally‐generated sensory consequences. Previous studies have shown that self‐initiation modulates neural and perceptual responses to identical stimulation. For example, event‐related potentials (ERPs) elicited by tones that follow a button press are reduced in amplitude relative to ERPs elicited by passively attended tones. However, previous EEG studies investigating visual stimuli in this context are rare, provide inconclusive results, and lack adequate control conditions with passive movements. Furthermore, although self‐initiation is known to modulate behavioral responses, it is not known whether differences in the amplitude of ERPs also reflect differences in perception of sensory outcomes. In this study, we presented to participants visual stimuli consisting of gray discs following either active button presses, or passive button presses, in which an electromagnet moved the participant's finger. Two discs presented visually 500–1250 ms apart followed each button press, and participants judged which of the two was more intense. Early components of the primary visual response (N1 and P2) over the occipital electrodes were suppressed in the active condition. Interestingly, suppression in the intensity judgment task was only correlated with suppression of the visual P2 component. These data support the notion of efference copy‐based forward model predictions in the visual sensory modality, but especially later processes (P2) seem to be perceptually relevant. Taken together, the results challenge the assumption that N1 differences reflect perceptual suppression and emphasize the relevance of the P2 ERP component.
Biophysical model of muscle spindle encoding
Authors: Housley Stephen N. , Powers Randal K. , Nardelli Paul , Lee Sebinne , Blum Kyle , Bewick Guy S. , Banks Robert W. , Cope Timothy C. 
Published: March 2023

AbstractMuscle spindles encode mechanosensory information by mechanisms that remain only partially understood. Their complexity is expressed in mounting evidence of various molecular mechanisms that play essential roles in muscle mechanics, mechanotransduction and intrinsic modulation of muscle spindle firing behaviour. Biophysical modelling provides a tractable approach to achieve more comprehensive mechanistic understanding of such complex systems that would be difficult/impossible by more traditional, reductionist means. Our objective here was to construct the first integrative biophysical model of muscle spindle firing. We leveraged current knowledge of muscle spindle neuroanatomy and in vivo electrophysiology to develop and validate a biophysical model that reproduces key in vivo muscle spindle encoding characteristics. Crucially, to our knowledge, this is the first computational model of mammalian muscle spindle that integrates the asymmetric distribution of known voltage‐gated ion channels (VGCs) with neuronal architecture to generate realistic firing profiles, both of which seem likely to be of great biophysical importance. Results predict that particular features of neuronal architecture regulate specific characteristics of Ia encoding. Computational simulations also predict that the asymmetric distribution and ratios of VGCs is a complementary and, in some instances, orthogonal means to regulate Ia encoding. These results generate testable hypotheses and highlight the integral role of peripheral neuronal structure and ion channel composition and distribution in somatosensory signalling.
Role of BDNF in Neuroplasticity Associated with Alcohol Dependence
Authors: Peregud Danil I. , Baronets Valeria Yu. , Terebilina Natalia N. , Gulyaeva Natalia V. 
Published: March 2023

Abstract
Chronic alcohol consumption is characterized by disturbances of neuroplasticity. Brain-derived neurotrophic factor (BDNF) is believed to be critically involved in this process. Here we aimed to review actual experimental and clinical data related to BDNF participation in neuroplasticity in the context of alcohol dependence. As has been shown in experiments with rodents, alcohol consumption is accompanied by the brain region-specific changes of BDNF expression and by structural and behavioral impairments. BDNF reverses aberrant neuroplasticity observed during alcohol intoxication. According to the clinical data parameters associated with BDNF demonstrate close correlation with neuroplastic changes accompanying alcohol dependence. In particular, the rs6265 polymorphism within the BDNF gene is associated with macrostructural changes in the brain, while peripheral BDNF concentration may be associated with anxiety, depression, and cognitive impairment. Thus, BDNF is involved in the mechanisms of alcohol-induced changes of neuroplasticity, and polymorphisms within the BDNF gene and peripheral BDNF concentration may serve as biomarkers, diagnostic or prognostic factors in treatment of alcohol abuse.
Semi-Automatic Defect Distinction of PAUT for High Strength Steel Corner Structure
Authors: Wang Qiang , Wang Xinghao , Zhang Lei 
Published: March 2023

Abstract
In this study, A GCN distinction network is proposed to identify the defect status of steel corner structures. In this defect determination method, the detected S-scan data is converted into A-scan by Doppler software to form a two-dimensional detection matrix, and the two dimensions are deflection angle stepping and sampling point on the acoustic distance respectively. GCN needs data node relations for GCN’s adjacent matrix, which concludes the shape of the sample and the reflection information and the structure of acoustic beam direction. The conventional inverse and threshold method are introduced in order to enhance classification performance. According to the node and the adjacency matrix relationship between nodes of affiliation and node sampling value automatically set the node label, The GCN model is constructed. Due to the characteristics of GCN, the beam length in the adjacent matrix cannot be changed again in the application test. Except for the detection model of Beamtool software, all other data processes and distinction are carried out automatically. In this study, the PAUT of low-alloy steel (30CrMnSi) was carried out by the PHASCAN II detector, to verify the effectiveness of the research method through natural wave and defect echo experiments which will be confused to distinguish.
Risk of adverse events from different drugs for SLE: a systematic review and network meta-analysis
Authors: Tian Jingru , Luo Yien , Wu Haijing , Long Hai , Zhao Ming , Lu Qianjin 
Published: March 2023

ObjectiveThe comparative safety of immunosuppressive drugs, biologicals and glucocorticoids (GC) for patients with SLE remains controversial. We aimed to investigate the specific side effects of the available SLE drugs in this population of patients.MethodsElectronic databases were systematically searched through September 2017 for randomised trials in patients with SLE. The primary outcomes were all-cause mortality and withdrawal related to adverse events (AEs). We performed a random-effects network meta-analysis to obtain estimates for primary and secondary outcomes and presented these estimates as ORs with 95% CIs.ResultsForty-four studies comprising 9898 participants were included in the network meta-analysis. No drug regimen was considered to be safer for reducing all-cause mortality. However, compared with cyclophosphamide, azathioprine (OR 3.04, 95% CI (1.44 to 6.42)) and cyclosporine (OR 3.28, 95% CI (1.04 to 10.35)) were significantly less safety in AE-related withdrawals, and GC was ranked lowest and led to higher withdrawal rates. Tacrolimus (TAC) was ranked high and showed a benefit in many outcomes. Biologicals and chloroquine also showed good safety in all of the available outcomes, while the beneficial effects of other immunosuppressive drugs were not substantial in different types of serious adverse events.ConclusionsTAC is the safest strategy for patients with SLE. Biologicals and chloroquine are also fairly safe for patients with SLE. The use of other immunosuppressive drugs and GC needs to be balanced against the potential harms of different types of AEs, and the practical safety of drug combinations still requires further trials to evaluate.
Patients’ characteristics and mortality in urgent/emergent/salvage transcatheter aortic valve replacement: insight from the OCEAN-TAVI registry
Authors: Enta Yusuke , Miyasaka Masaki , Taguri Masataka , Tada Norio , Hata Masaki , Watanabe Yusuke , Naganuma Toru , Yamawaki Masahiro , Yamanaka Futoshi , Shirai Shinichi , Ueno Hiroshi , Mizutani Kazuki , Tabata Minoru , Takagi Kensuke , Yamamoto Masanori , Hayashida Kentaro 
Published: March 2023

ObjectivesPatients’ backgrounds and clinical outcomes in urgent/emergent/salvage transcatheter aortic valve replacement (Em-TAVR) remain unclear. We investigated patient characteristics and the mortality in Em-TAVR and the predictors for the need for Em-TAVR.MethodsWe consecutively enrolled 1613 patients undergoing TAVR for severe aortic stenosis between October 2013 and July 2016 from the Optimised transCathEter vAlvular interventioN (OCEAN)-transcatheter aortic valve implantation (TAVI) registry. The urgency was based on the European System for Cardiac Operative Risk Evaluation II. Urgent, emergent or salvage were included with the Em-TAVR group and elective with the El-TAVR group.ResultsEm-TAVR was observed in 87 (5.4%) patients. A higher Clinical Frailty Scale (CFS), peripheral artery disease (PAD), hypoalbuminaemia, reduced left ventricular ejection fraction (LVEF) and preoperative at least moderate mitral regurgitation (MR) predicted the need for the Em-TAVR by the multivariate logistic regression analysis. The Em-TAVR group had the higher Society of Thoracic Surgeons Score (13.7 (IQR 8.2–21.0) vs 6.5 (IQR 4.6–9.2); p<0.001) and higher 30-day mortality (9.2% vs 1.3%; p<0.001) than the El-TAVR group. Accordingly, Kaplan-Meier analysis showed that the cumulative mortality was higher in the Em-TAVR group than that in the El-TAVR group (log-rank; p<0.001). However, Em-TAVR did not predict mortality in the multivariate Cox regression analysis.ConclusionsEm-TAVR was performed in 5.4% of patients. Higher CFS, PAD, hypoalbuminaemia, reduced LVEF and preprocedural MR predicted the need for Em-TAVR. Em-TAVR was not a predictor for mortality in the multivariate analysis, suggesting that it is a reasonable treatment option.
Diastolic index as a short-term prognostic factor in heart failure with preserved ejection fraction
Authors: Hoshida Shiro , Hikoso Shungo , Shinoda Yukinori , Tachibana Koichi , Minamisaka Tomoko , Tamaki Shunsuke , Yano Masamichi , Hayashi Takaharu , Nakagawa Akito , Nakagawa Yusuke , Yamada Takahisa , Yasumura Yoshio , Nakatani Daisaku , Sakata Yasushi 
Published: March 2023

ObjectiveDuring follow-up time, the value of prognostic factors may change, especially in the elderly patients, and the altered extent may affect the prognosis. We aimed to clarify the significance of the ratio of diastolic elastance (Ed) to arterial elastance (Ea), (Ed/Ea=(E/e’)/(0.9×systolic blood pressure)), an afterload-integrated diastolic index, in relation to follow-up periods and other laboratory factors, on the prognosis of elderly patients with heart failure with preserved ejection fraction (HFpEF).MethodsWe studied 552 HFpEF patients hospitalised for acute decompensated heart failure (men/women: 255/297). Blood testing and transthoracic echocardiography were performed before discharge. The primary endpoint was all-cause mortality.ResultsDuring a median follow-up of 508 days, 88 patients (men/women: 39/49) had all-cause mortality. During the first year after discharge, Ed/Ea (p=0.045) was an independent prognostic factor in association with albumin (p<0.001) and N-terminal pro-brain natriuretic peptide (NT-proBNP, p=0.005) levels after adjusting for age and sex in the multivariate Cox hazard analysis. However, at 1 to 3 years after discharge, no other significant prognostic factors, except for albumin level (p=0.046), were detected. In the subgroup analysis, albumin, but not NT-proBNP level, showed a significant interaction with Ed/Ea for prognosis (p=0.047).ConclusionThe prognostic significance of a haemodynamic parameter such as Ed/Ea may be valid only during a short-term period, but that of albumin was persisting during the entire follow-up period in the elderly patients. The clinical significance of prognostic factors in HFpEF patients may differ according to the follow-up period.
Role of peripheral sensory neuron mu-opioid receptors in nociceptive, inflammatory, and neuropathic pain
Authors: Barpujari Awinita , Ford Neil , He Shao-Qiu , Huang Qian , Gaveriaux-Ruff Claire , Dong Xinzhong , Guan Yun , Raja Srinivasa 
Published: March 2023

Background and objectiveThe role of peripheral mu-opioid receptors (MOPs) in chronic pain conditions is not well understood. Here, we used a combination of mouse genetics, behavioral assays, and pharmacologic interventions to investigate the contribution of primary afferent MOPs to nociceptive, inflammatory, and neuropathic pain, as well as to opioid analgesia.MethodsWe generated conditional knockout mice in which MOPs were selectively deleted in primary sensory neurons. Inflammatory and neuropathic pain states were induced in mutant and control wild-type mice and their behavioral responses to noxious stimuli were compared. Gross motor function was also evaluated. Immunohistochemistry was used to assess MOP expression in the dorsal root ganglia, periaqueductal gray, and small intestine. The effects of MOP agonists DALDA (dermorphin [D-Arg2, Lys4] (1–4) amide) and morphine were evaluated in pain behavior assays, and their effects on neuronal physiology in the dorsal root ganglia were evaluated in whole-cell patch-clamp recordings.ResultsConditional MOP knockouts and control mice exhibited similar behavioral responses to acute nociceptive stimuli and developed similar inflammation-induced hypersensitivity. Unilateral nerve injury in animals lacking peripheral MOPs induced enhanced, bilateral mechanical allodynia. Subcutaneously administered DALDA was unable to decrease the hypersensitivity induced by inflammation and nerve injury in MOP knockout animals, and morphine’s antinociceptive effects were significantly attenuated in the absence of peripheral MOPs.ConclusionMOPs in primary sensory neurons contribute to the modulation of neuropathic pain behavior and opioid analgesia. Our observations highlight the clinical potential of peripherally acting opioid agonists in the management of inflammatory and neuropathic pain.