bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer
Authors: Tang Mingshuang , Wu Xueyao , Zhang Wenqiang , Cui Huijie , Zhang Li , Yan Peijing , Yang Chao , Wang Yutong , Chen Lin , Xiao Chenghan , Liu Yunjie , Zou Yanqiu , Yang Chunxia , Zhang Ling , Yao Yuqin , Liu Zhenmi , Li Jiayuan , Jiang Xia , Zhang Ben 
Published: July 2023

Abstract

Background and Hypothesis
While the phenotypic association between schizophrenia and breast cancer has been observed, the underlying intrinsic link is not adequately understood. We aim to conduct a comprehensive interrogation on both phenotypic and genetic relationships between schizophrenia and breast cancer.

Study Design
We first used data from UK Biobank to evaluate a phenotypic association and performed an updated meta-analysis incorporating existing cohort studies. We then leveraged genomic data to explore the shared genetic architecture through a genome-wide cross-trait design.

Study Results
Incorporating results of our observational analysis, meta-analysis of cohort studies suggested a significantly increased incidence of breast cancer among women with schizophrenia (RR = 1.30, 95% CIs = 1.14–1.48). A positive genomic correlation between schizophrenia and overall breast cancer was observed (rg = 0.12, P = 1.80 × 10−10), consistent across ER+ (rg = 0.10, P = 5.74 × 10−7) and ER– subtypes (rg = 0.09, P = .003). This was further corroborated by four local signals. Cross-trait meta-analysis identified 23 pleiotropic loci between schizophrenia and breast cancer, including five novel loci. Gene-based analysis revealed 27 shared genes. Mendelian randomization demonstrated a significantly increased risk of overall breast cancer (OR = 1.07, P = 4.81 × 10−10) for genetically predisposed schizophrenia, which remained robust in subgroup analysis (ER+: OR = 1.10, P = 7.26 × 10−12; ER–: OR = 1.08, P = 3.50 × 10−6). No mediation effect and reverse causality was found.

Conclusions
Our study demonstrates an intrinsic link underlying schizophrenia and breast cancer, which may inform tailored screening and management of breast cancer in schizophrenia.
Functional outcomes after bilateral refractive lens exchange with a continuous-range-of-vision intraocular lens
Authors: Khoramnia Ramin , Baur Isabella D. , Łabuz Grzegorz , Köppe Maximilian K. , Hallak Mustafa K. , Auffarth Gerd U. 
Published: July 2023

Purpose:
To clinically evaluate a diffractive continuous-range-of-vision intraocular lens (IOL) that combines bifocal and extended depth-of-focus technologies in refractive lens exchange (RLE) patients.

Setting:
University eye clinic.

Design:
Prospective interventional clinical study.

Methods:
Bilateral implantation of the TECNIS Synergy IOL was performed during a RLE procedure in 28 patients. At 3 months postoperatively, uncorrected (UDVA) and corrected (CDVA) distance visual acuities, uncorrected (UIVA) and distance-corrected (DCIVA) intermediate visual acuities at 80 cm, and uncorrected (UNVA) and distance-corrected (DCNVA) near visual acuities at 40 cm were assessed. Defocus curve testing and contrast sensitivity testing were also performed.

Results:
Binocular UDVA and CDVA of 56 eyes (28 patients) were −0.06 ± 0.07 logMAR and −0.13 ± 0.05 logMAR, respectively. UIVA and DCIVA were −0.06 ± 0.05 logMAR and −0.08 ± 0.06 logMAR, and UNVA and DCNVA were −0.01 ± 0.07 logMAR and −0.04 ± 0.07 logMAR. The defocus curve revealed a visual acuity of 0.10 logMAR or better from +0.50 to −3.00 diopters (D). Photopic contrast sensitivity at spatial frequencies 3.0, 6.0, 12.0, and 18.0 was 1.68 ± 0.20, 1.77 ± 0.19, 1.45 ± 0.18, and 1.02 ± 0.19 log units, respectively. Mesopic contrast sensitivity at the same frequencies was 1.56 ± 0.20, 1.44 ± 0.25, 0.92 ± 0.38, and 0.44 ± 0.37, respectively.

Conclusions:
The Synergy IOL provided very good distance, intermediate, and near visual outcomes. A visual acuity of 0.10 logMAR or better was achieved from +0.50 to −3.0 D. Contrast sensitivity was within the normal range.
The Impact of an Electronic Best Practice Advisory on Patients' Physical Activity and Cardiovascular Risk Profile
Authors: McCarthy Margaret M. , Szerencsy Adam , Fletcher Jason , Taza-Rocano Leslie , Weintraub Howard , Hopkins Stephanie , Applebaum Robert , Schwartzbard Arthur , Mann Devin , D'Eramo Melkus Gail , Vorderstrasse Allison , Katz Stuart D. 
Published: July 2023

Background
Regular physical activity (PA) is a component of cardiovascular health and is associated with a lower risk of cardiovascular disease (CVD). However, only about half of US adults achieved the current PA recommendations.

Objective
The study purpose was to implement PA counseling using a clinical decision support tool in a preventive cardiology clinic and to assess changes in CVD risk factors in a sample of patients enrolled over 12 weeks of PA monitoring.

Methods
This intervention, piloted for 1 year, had 3 components embedded in the electronic health record: assessment of patients' PA, an electronic prompt for providers to counsel patients reporting low PA, and patient monitoring using a Fitbit. Cardiovascular disease risk factors included PA (self-report and Fitbit), body mass index, blood pressure, lipids, and cardiorespiratory fitness assessed with the 6-minute walk test. Depression and quality of life were also assessed. Paired t tests assessed changes in CVD risk.

Results
The sample who enrolled in the remote patient monitoring (n = 59) were primarily female (51%), White adults (76%) with a mean age of 61.13 ± 11.6 years. Self-reported PA significantly improved over 12 weeks (P = .005), but not Fitbit steps (P = .07). There was a significant improvement in cardiorespiratory fitness (469 ± 108 vs 494 ± 132 m, P = .0034), and 23 participants (42%) improved at least 25 m, signifying a clinically meaningful improvement. Only 4 participants were lost to follow-up over 12 weeks of monitoring.

Conclusions
Patients may need more frequent reminders to be active after an initial counseling session, perhaps getting automated messages based on their step counts syncing to their electronic health record.
The Feasibility of the Three-Dimensional Footswitch-Operated Robotic Arm Exoscope for Cochlear Implant Surgery
Authors: Karinen Eerika , Iso-Mustajärvi Matti , Dietz Aarno 
Published: July 2023

Objective
To compare the three-dimensional (3D) footswitch-operated robotic arm exoscope with the operating microscope (OM) in cochlear implant surgery.

Study design
Matched case–control study.

Patients
Cochlear implantation was performed with the exoscope on unselected patients with normal temporal anatomy. The control group that underwent cochlear implantation with the OM was case matched with respect to age, anatomy, surgical technique, and type of anesthesia.

Interventions
Cochlear implantation performed with the 3D exoscope.

Main Outcome measures
Surgical time, occupation of the operation theater, surgical results, and user experience evaluated by a questionnaire.

Results
Eleven patients (13 ears) were successfully operated on with the exoscope. In the exoscope group, we observed one minor intraoperative complication, where the middle dura was exposed during mastoidectomy. Although no clear preference was evident for either device in the overall rating, the subdomain rating revealed that the exoscope’s image quality was deemed inferior, especially at higher magnifications where pixelation became noticeable. The exoscope received higher scores for usability, particularly excelling in terms of surgeon’s ergonomic and comfortability. There was a statistically significant difference in mean surgical time, 146 and 129 min for the exoscope and OM group, respectively.

Conclusions
Cochlear implant surgery was found to be feasible with a 3D exoscope. However, there is a learning curve to overcome regarding handling and the different quality of the image. The exoscope provides better ergonomics for the surgeon.
Differential Volume Increase of Endolymphatic Compartments in Ménière's Disease Is Inversely Associated With Membrane Thickness
Authors: Büki Béla , Ward Bryan K. , Santos Felipe 
Published: July 2023

Objectives
Our aim in this study was to characterize the morphology of the endolymphatic compartment on histopathology in individuals with Ménière's disease (MD) and to determine why hydrops of the saccule is more pronounced than that of other compartments of the inner ear in MD.

Methods
Temporal bones from 9 patients with idiopathic MD and from 10 individuals without MD/endolymphatic hydrops were examined. The inner ear fluid compartments in normal ears, and ears with MD were three-dimensionally reconstructed and their volume was calculated. The thickness of the membranes of the labyrinth was measured, and both ruptures of the membranes and patency of the utriculoendolymphatic (UEV; Bast's) valve were assessed.

Results
In ears with MD, the saccule and the cochlear duct were most frequently hydropic; the utricle was involved approximately half as frequently. In ears without MD, the Reissner's membrane and the membranous wall of the saccule were thinner than that of the utricle and of the lateral semicircular canal (p < 0.01). The lateral semicircular canal did not show signs of hydrops. In all ears with MD in which the utricle exceeded the average volume of normals (6 of 12), the UEV was open or there was a rupture in the utricle.

Conclusion
Increases in endolymphatic pressure may cause a primary swelling of the apical cochlear duct and saccule, both of which have relatively thin membranes. Hydrops in the utricle may occur less frequently because of a thicker wall, because of a functioning UEV, and when the saccule has already occupied most of the vestibular perilymphatic space.
Are “buy X get X free” price promotions effective? An acquisition-transaction value perspective
Authors: Bhatt Siddharth Harshkant , Pai Dinesh Ramdas 
Published: July 2023

Purpose“Buy X Get X Free” promotions are popular across retail settings. Retailers promote a variety of products using this promotional frame. However, past research contains mixed findings about the effectiveness of this promotion compared to the straightforward discount on a single unit of a product. The goal of this research is to employ a theoretical lens to examine the effectiveness of “Buy X Get X Free” promotions.Design/methodology/approachThe theoretical framework was tested in two experiments using different products and samples. The data collected from each experiment were analyzed using both descriptive and inferential techniques to assess support for the theoretical arguments.FindingsFindings reveal that at identical levels of per-unit discount, the “Buy X Get X Free” promotion is perceived less favorably by consumers than a straightforward single-unit discount. Consumers perceive lower transaction value and acquisition value and, thereby, a lower purchase intention, from the “Buy X Get X Free” promotion compared to a single-unit discount.Practical implicationsThis research was conducted keeping in mind the popularity of the “Buy X Get X Free” promotion in the real world. The findings caution retailers against indiscriminately using this promotional frame.Originality/valueUsing a theoretical lens, this research proposes and validates a framework to systematically examine consumers' perceptions of the two popular discount frames. The proposed theoretical framework provides a richer understanding of the underlying consumer psychology that drives the evaluation of these promotions. Further, primary data from lab experiments validates the framework. The research also helps advance the understanding of consumer evaluation of sales promotions in general.
Projecting complex categories: biodynamic wine producers’ online identity
Authors: Fox Kenneth A. , Wilson Grant Alexander 
Published: July 2023

Purpose
This paper aims to investigate how producers of biodynamic and sustainable wine portray their brand identity online.

Design/methodology/approach
The study uses an inductive approach to qualitative content analysis of wine producers’ websites. The authors use a theoretical starting point based on the categorizations literature related to institutional scripts and identity projection.

Findings
Producers adopt identity templates similar to the provenance and glory templates established in extant research. They demonstrate templates of community, quality, spirituality and sustainability, but there is a break in the templates, and they adopt a pseudo-rationalist template, avoiding detailed descriptions of practices and underpinning philosophy, leaving any references to them opaque and ambiguous. This may be due to concerns over scientific skepticism or spiritual suspicion, or anticipation of a lack of consumer knowledge.

Research limitations/implications
The geographical location of the sample poses limitations to the results of the study. However, the study provides an examination of the nuances of self-categorization as it relates to identity projection, prompting further investigation into its positive and negative potential.

Practical implications
Research on the connection between quality perceptions and experience and credence attributes suggests producers should do more to emphasize the philosophy underpinning biodynamics.

Originality/value
The study contributes to research on marketing for inherently sustainable producers who may suffer potential negative reactions in general and biodynamic wine producers in particular. This study provides nuance to the understanding of negative reactions to novel and innovative wine production practices.
Reverse compassion: value-in-use and value-in-context of healthcare services during crisis
Authors: De Rosis Sabina , Jamieson Gilmore Kendall , Nuti Sabina 
Published: July 2023

PurposeUsing data from a continuous and ongoing cross-sectional web survey on hospitalisation service experiences in two Italian regions, the authors used multilevel and multivariate logistic regression models to identify factors related to users' demographics, emotional and informative support, technical and physical aspects of the provision, influencing satisfaction and willingness-to-recommend, before and during a crisis.Design/methodology/approachThe value-in-use, defined in terms of a positive or negative value given by the experience with services, can be evaluated by users and influenced by the context of provision. The authors tested whether and how the value-in-use of services changed in a context of crisis. This study is applied to the healthcare sector during the coronavirus disease 2019 (COVID-19) epidemic, by evaluating the impact of the pandemic on hospitalisation experience.FindingsOverall, analyses of 8,712 questionnaires found a greater value after the pandemic spread. In a time of crisis, technical and informative aspects of care were found to be most valued by patients that may recognise the extraordinary professionalism of workers during the crisis.Research limitations/implicationsThis study empirically suggests that context can affect the evaluation of value-in-use by patients during unprecedented circumstances, producing additional value-in-context.Practical implicationsThese findings imply that during critical periods where there is less scope for expressions of gratitude and appreciation towards front-line workers, user-reported data can be used for motivating professionals and increase resilience. These results reiterate the need to continue collecting and reporting the service users' voices, including as activity within plans for managing challenging situations.Social implicationsThe level of healthcare system distress, due to the COVID-19 epidemic, positively affects patients' propensity to recommend, which the authors suggest is driven by healthcare services' feelings of reverse compassion. These findings imply that during critical periods where there is less scope for expressions of gratitude and appreciation towards front-line workers, user-reported data can be used for motivating professionals and increase resilience, which can have positive social implications. These results reiterate the need to continue collecting and reporting the service users' voices, including as activity within plans for managing challenging situations.Originality/valueResearch based on the intersection of theoretical and empirical research regarding value-in-use, value-in-context and service quality measured through user experience is scarce, in particular in the healthcare sector. The authors' findings set the direction for future research on the influence of context on value creation and value creation's perception by users, on the concept of reverse compassion and on reverse compassion's impact on organisational well-being, particularly in times of crisis.
Inter‐municipal cooperation and local government perspectives on community health and wellbeing
Authors: Morgan Michelle J. , Stratford Elaine , Harpur Siobhan , Rowbotham Samantha , Chamberlain Dan 
Published: July 2023

AbstractGlobally, local governments face increasing service delivery demands and citizen expectations, including in relation to community health and wellbeing. Inter‐municipal cooperation is one strategy to respond to those demands. In Australia, however, there is limited empirical research about the types of inter‐municipal cooperation local governments engage in and about their perspectives on community health and wellbeing. Without such knowledge, limits are placed on strategies the sector can develop and deploy to collectively tackle complex issues that extend beyond municipal boundaries. Responding to that gap in research and those consequential challenges for strategy, we surveyed municipal personnel in all 29 local governments in the state of Tasmania and included questions to quantify inter‐municipal cooperation using social network analysis. Results show the extent to which local governments cooperate across seven domains and reveal that participants prioritised community health and wellbeing and described funding, collaboration, legislation, and systems thinking as ways to advance their contributions to that priority. We found social network analysis to be a useful method to measure inter‐municipal cooperation; however, further research into how and why local governments collaborate across diverse service types would help inform how those services can be enhanced, including for community health and wellbeing.Points for practitioners
Inter‐municipal cooperation is important for local governments to manage resources with increasing service delivery demands and citizen expectations.
This Australian study shows how inter‐municipal cooperation can be quantified and articulated visually using social network analysis—a method that could measure changes over time and enable cross‐jurisdiction comparisons.
In Tasmania:

inter‐municipal cooperation occurs in distinct regional networks and more research about how and why these networks function across diverse service types could inform service enhancement; and
those in local government want to advance their contributions to community health and wellbeing and need support in the form of funding, collaboration, legislation, and systems thinking capacity.
Merging two eDNA metabarcoding approaches and citizen‐science‐based sampling to facilitate fish community monitoring along vast Sub‐Saharan coastlines
Authors: Burian Alfred , Bruce Kat , Tovela Erica , Bakker Judith , Balcells Laura , Bennett Rhett , Chordekar Sarah , Costa Hugo M. , Crampton‐Platt Alex , de Boer Hugo , Ross‐Gillespie Vere , de Sacramento Antonio , Sidat Naseeba , Simbine Luisa , Ready Jonathan , Tang Cuong , Mauvisseau Quentin 
Published: July 2023

AbstractThe coastline of Sub‐Saharan Africa hosts highly diverse fish communities of great conservation value, which are also key resources for local livelihoods. However, many costal ecosystems are threatened by overexploitation and their conservation state is frequently unknown due to their vast spatial extent and limited monitoring budgets. Here, we evaluated the potential of citizen science‐based eDNA surveys to alleviate such chronic data deficiencies and assessed fish communities in Mozambique using two 12S metabarcoding primer sets. Samples were either collected by scientific personnel or trained community members and results from the two metabarcoding primers were combined using a new data merging approach. Irrespective of the background of sampling personnel, a high average fish species richness was recorded (38 ± 20 OTUs per sample). Individual sections of the coastline largely differed in the occurrence of threatened and commercially important species, highlighting the need for regionally differentiated management strategies. A detailed comparison of the two applied primer sets revealed an important trade‐off in primer choice with MiFish primers amplifying a higher number of species but Riaz primers performing better in the detection of threatened fish species. This trade‐off could be partly resolved by applying our new data‐merging approach, which was especially designed to increase the robustness of multiprimer assessments in regions with poor reference libraries. Overall, our study provides encouraging results but also highlights that eDNA‐based monitoring will require further improvements of, for example, reference databases and local analytical infrastructure to facilitate routine applications in Sub‐Saharan Africa.
An update on the seizures beget seizures theory
Authors: Jiruska Premysl , Freestone Dean , Gnatkovsky Vadym , Wang Yujiang 
Published: July 2023

AbstractSeizures beget seizures is a longstanding theory that proposed that seizure activity can impact the structural and functional properties of the brain circuits in ways that contribute to epilepsy progression and the future occurrence of seizures. Originally proposed by Gowers, this theory continues to be quoted in the pathophysiology of epilepsy. We critically review the existing data and observations on the consequences of recurrent seizures on brain networks and highlight a range of factors that speak for and against the theory. The existing literature demonstrates clearly that ictal activity, especially if recurrent, induces molecular, structural, and functional changes including cell loss, connectivity reorganization, changes in neuronal behavior, and metabolic alterations. These changes have the potential to modify the seizure threshold, contribute to disease progression, and recruit wider areas of the epileptic network into epileptic activity. Repeated seizure activity may, thus, act as a pathological positive‐feedback mechanism that increases seizure likelihood. On the other hand, the time course of self‐limited epilepsies and the presence of seizure remission in two thirds of epilepsy cases and various chronic epilepsy models oppose the theory. Experimental work showed that seizures could induce neural changes that increase the seizure threshold and decrease the risk of a subsequent seizure. Due to the complex nature of epilepsies, it is wrong to consider only seizures as the key factor responsible for disease progression. Epilepsy worsening can be attributed to the various forms of interictal epileptiform activity or underlying disease mechanisms. Although seizure activity can negatively impact brain structure and function, the “seizures beget seizures” theory should not be used dogmatically but with extreme caution.