bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Using Simulation to Predict the Performance of Robot Swarms
Authors: Ligot Antoine , Birattari Mauro 
Published: December 2022

AbstractThe discrepancy between simulation and reality–known as the reality gap–is one of the main challenges associated with using simulations to design control software for robot swarms. Currently, the reality-gap problem necessitates expensive and time consuming tests on physical robots to reliably assess control software. Predicting real-world performance accurately without recurring to physical experiments would be particularly valuable. In this paper, we compare various simulation-based predictors of the performance of robot swarms that have been proposed in the literature but never evaluated empirically. We consider (1) the classical approach adopted to estimate real-world performance, which relies on the evaluation of control software on the simulation model used in the design process, and (2) some so-called pseudo-reality predictors, which rely on simulation models other than the one used in the design process. To evaluate these predictors, we reuse 1021 instances of control software and their real-world performance gathered from seven previous studies. Results show that the pseudo-reality predictors considered yield more accurate estimates of the real-world performance than the classical approach.
The frequency of defective genomes in Omicron differs from that of the Alpha, Beta and Delta variants
Authors: Campos Carolina , Colomer-Castell Sergi , Garcia-Cehic Damir , Gregori Josep , Andrés Cristina , Piñana Maria , González-Sánchez Alejandra , Borràs Blanca , Parés-Badell Oleguer , Adombi Caroline Melanie , Ibañez-Lligoña Marta , Esperalba Juliana , Codina Maria Gema , Rando-Segura Ariadna , Saubí Narcis , Esteban Juan Ignacio , Rodriguez-Frías Francisco , Pumarola Tomàs , Antón Andrés , Quer Josep 
Published: December 2022

AbstractThe SARS-CoV-2 Omicron variant emerged showing higher transmissibility and possibly higher resistance to current COVID-19 vaccines than other variants dominating the global pandemic. In March 2020 we performed a study in clinical samples, where we found that a portion of genomes in the SARS-CoV-2 viral population accumulated deletions immediately before the S1/S2 cleavage site (furin-like cleavage site, PRRAR/S) of the spike gene, generating a frameshift and appearance of a premature stop codon. The main aim of this study was to determine the frequency of defective deletions in prevalent variants from the first to sixth pandemic waves in our setting and discuss whether the differences observed might support epidemiological proposals. The complete SARS-CoV-2 spike gene was deeply studied by next-generation sequencing using the MiSeq platform. More than 90 million reads were obtained from respiratory swab specimens of 78 COVID-19 patients with mild infection caused by the predominant variants circulating in the Barcelona city area during the six pandemic waves: B.1.5, B.1.1, B.1.177, Alpha, Beta, Delta, and Omicron. The frequency of defective genomes found in variants dominating the first and second waves was similar to that seen in Omicron, but differed from the frequencies seen in the Alpha, Beta and Delta variants. The changing pattern of mutations seen in the various SARS-CoV-2 variants driving the pandemic waves over time can affect viral transmission and immune escape. Here we discuss the putative biological effects of defective deletions naturally occurring before the S1/S2 cleavage site during adaption of the virus to human infection.
Identification of potential light deficiency response regulators in endangered species Magnolia sinostellata
Authors: Lu Danying , Xu Bin , Yu Qin , Liu Zhigao , Ren Mingjie , Wang Yaling , Zhang Shouzhou , Wu Chao , Shen Yamei 
Published: December 2022

AbstractMagnolia sinostellata is one of the endangered species in China and largely suffers light deficiency stress in the understory of forest. However, the weak light response molecular mechanism remains unclear. More importantly, hub genes in the molecular network have not been pinpointed. To explore potential regulators in the mechanism, weighted gene co-expression network analysis (WGCNA) was performed to analysis the trancriptome data of M. sinostellata leaves subjected to weak light with different time points. Gene co-expression analysis illustrated that module 1, 2 and 3 were closely associated with light deficiency treatment, which. Gene ontology and KEGG analyses showed that genes in module 1 mainly participated in amino and nucleotide metabolism, module 2 mostly involved in carbon fixation and module 3 mostly regulated photosynthesis related pathways, among which 6, 7 and 8 hub genes were identified, respectively. Hub genes isoform_107196 in module 1 and isoform_55976 in module 2 were unique to M. sinostellata. This study found that light deficiency inhibited photosynthesis and stress tolerance, while improved carbon metabolism and flowering related pathways in M. sinostellata, which can impact its accumulation reserves of growth and reproduction in the next season. In addition, key shade response regulators identified in this study have laid a firm foundation for further investigation of shade response molecular mechanism and protection of other shade sensitive plants.
Biometric recognition of newborns and young children for vaccinations and health care: a non-randomized prospective clinical trial
Authors: Kalisky Tom , Saggese Steven , Zhao Yunting , Johnson Daniel , Azarova Maya , Duarte-Vera Lilia Edith , Almada-Salazar Lucila Alejandra , Perales-Gonzalez Daniel , Chacon-Cruz Enrique , Wang Jiaxing , Graham Rishi , Hubenko Alexandra , Hall Drew A. , Aronoff-Spencer Eliah 
Published: December 2022

AbstractAlthough universal biometrics have been broadly called for, and there are many validated technologies to recognize adults, these technologies have been ineffective in newborns and young children. The present work describes the development and clinical testing of a fingerprint capture system for longitudinal biometric recognition of newborns and young children to support vaccination and clinical follow-up. The reader consists of a high-resolution monochromatic imaging system with an ergonomic industrial design to comfortably support and align infant fingers for imaging without a platen. This imaging approach without a platen, also called free-space imaging, reduces fingerprint distortion and ensures a more consistent finger placement. This system was tested in a newborn ward and immunization clinic at an urban hospital in Baja, California, Mexico, from 2017 to 2019. Nearly five hundred children were enrolled and followed for up to 24 months. With a protocol of imaging all ten fingers, the failure to enroll (FTE) rate was < 1% when acquiring at least two fingers for all ages and < 2% when enrolling at least four fingers. The verification (1:1) true accept rate (TAR) was 77% for newborns enrolled at ≤ 3 days of age and 96% for those enrolled at ≥ 4 days of age, both at a time gap of 15–30 days after enrollment at a false accept rate (FAR) of 0.1%. Using the top-ranked match score, the identification rate (1:many) was 86% for the ≤ 3 days enrollment age and 97% for age ≥ 4 days for a single finger at 15–30 days after enrollment. The enrollment protocol and the frequency of updating will increase for infants compared to adults. However, these data suggest that a high-resolution, free space imaging technique may fill the final gap for universal biometrics across all populations called for by the United Nations Sustainable Development Goal 16.9.
Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy
Authors: Yu Koh Xin , Koh Xiao Hui , Spiegelberg Diana , Jha Preeti , Nestor Marika , Hwang Le-ann , Tan Ban Xiong , Lane David Philip 
Published: December 2022

AbstractThe RON receptor tyrosine kinase is an exceptionally interesting target in oncology and immunology. It is not only overexpressed in a wide variety of tumors but also has been shown to be expressed on myeloid cells associated with tumor infiltration, where it serves to dampen tumour immune responses and reduce the efficacy of anti-CTLA4 therapy. Potent and selective inhibitory antibodies to RON might therefore both inhibit tumor cell growth and stimulate immune rejection of tumors. We derived cloned and sequenced a new panel of exceptionally avid anti-RON antibodies with picomolar binding affinities that inhibit MSP-induced RON signaling and show remarkable potency in antibody dependent cellular cytotoxicity. Antibody specificity was validated by cloning the antibody genes and creating recombinant antibodies and by the use of RON knock out cell lines. When radiolabeled with 89-Zirconium, the new antibodies 3F8 and 10G1 allow effective immuno-positron emission tomography (immunoPET) imaging of RON-expressing tumors and recognize universally exposed RON epitopes at the cell surface. The 10G1 was further developed into a novel bispecific T cell engager with a 15 pM EC50 in cytotoxic T cell killing assays.
Insights from the Niger Delta Region, Nigeria on the impacts of urban pollution on the functional organisation of Afrotropical macroinvertebrates
Authors: Edegbene Augustine Ovie , Akamagwuna Frank Chukwuzuoke 
Published: December 2022

AbstractAnthropogenic activities, including urbanisation and industrialisation threaten stream ecological integrity, ecosystem community structure and ecosystem functioning of rivers and streams worldwide. However, developing sustainable monitoring strategies for ecological health remains a critical challenge in Africa. We examined the effects of urban disturbance on macroinvertebrate Functional Feeding Groups in selected streams in the Niger Delta Region of Nigeria. We sampled 11 sites between 2008 and 2012 and grouped into three site groups (Site groups 1 > 2 > 3). The groups represent an increasing gradient of urban pollution. Our result showed that urban-induced disturbances affected physicochemical variables in the study area (PERMANOVA; p < 0.05), with nutrients NO2-N, PO4-P, and electrical conductivity being significantly higher in impacted Site group 3 (ANOVA, p < 0.05). Predators and gatherers were the most dominant Functional Feeding Group recorded in the study area, while shredders were the least abundant macroinvertebrate Functional Feeding Groups. The multivariate RLQ analysis revealed that shredders, predators, and scrapers were tolerant of urban pollution, whereas gatherers were sensitive to increasing urban pollution. Overall, macroinvertebrates Functional Feeding Groups responded differentially to urban pollution in the Niger Delta Region. Identifying pollution indicator Functional Feeding Groups is seen as an important step towards developing a reliable, low-cost tool for riverine monitoring of urban pollution effects in Africa.
Trueness of full-arch dental models obtained by digital and conventional impression techniques: an in vivo study
Authors: Onbasi Yonca , Abu-Hossin Sabrin , Paulig Maria , Berger Lara , Wichmann Manfred , Matta Ragai-Edward 
Published: December 2022

AbstractThe aim of this study was to compare the trueness of complete- and partial-arch impressions obtained using conventional impression materials and intraoral scanners in vivo. Full-arch impressions were taken using polyether and polyvinylsiloxane. Gypsum casts were digitized using a laboratory scanner (IM, AF). Casts obtained from polyether impressions were also scanned using an industrial blue light scanner to construct 3D reference models. Intraoral scanning was performed using CEREC Omnicam (CO) and Trios 3 (TR). Surface matching software (Atos Professional) enabled to determine the mean deviations (mean distances) from the reference casts. Statistically significant discrepancies were calculated using the Wilcoxon signed-rank test. The mean distance for trueness ranged from 0.005 mm (TR) to 0.023 mm (IM) for the full arch, from 0.001 mm (CO) to 0.068 mm (IM) for the anterior segment, and from 0.019 mm (AF) to 0.042 mm (IM) for the posterior segment. Comparing the anterior vs. the posterior segment, significantly less deviations were observed for anterior with CO (p < 0.001) and TR (p < 0.001). Full-arch comparisons revealed significant differences between AF vs. IM (p = 0.014), IM vs. CO (p = 0.002), and IM vs. TR (p = 0.001). Full-arch trueness was comparable when using Affinis and the two intraoral scanners CEREC Omnicam and Trios 3. The digital impression devices yielded higher local deviations within the complete arch. Digital impressions of the complete arch are a suitable and reliable alternative to conventional impressions. However, they should be used with caution in the posterior region.Trial registration: Registration number at the German Clinical Trial Register (04.02.2022): DRKS00027988 (https://trialsearch.who.int/).
Testosterone is associated with abdominal body composition derived from computed tomography: a large cross sectional study
Authors: Han Seungbong , Jeon Young-Jee , Lee Tae Young , Park Gyung-Min , Park Sungchan , Kim Seong Cheol 
Published: December 2022

AbstractThe aim of this study was to evaluate the association between serum testosterone and abdominal body composition based on abdominopelvic computed tomography (APCT) measurements after adjusting for individual metabolic syndrome components. We performed a cross-sectional study using male subjects (age range: 22–84 years) who underwent a general health examination with abdominopelvic computed tomography and testosterone measurements. Body composition was evaluated with APCT. To confirm an association between testosterone and abdominal body composition, we conducted linear regression analysis. The effect of abdominal body composition was adjusted for important clinical factors such as age, albumin, and metabolic components in the multivariable regression analysis. Overall, 1453 subjects were included in the primary analysis. After adjustment for age, individual metabolic components, albumin, hemoglobin A1c, and C-reactive protein, we found that subcutaneous fat area index (β = − 0.042, p < 0.001), total abdominal muscle area index (β = 0.115, p < 0.001), normal attenuation muscle area index (β = 0.070, p < 0.001), and loge-transformed lower attenuation muscle area index (β = 0.140, p = 0.002) had an association with loge-transformed testosterone level. After adjusting for individual metabolic syndrome components, testosterone was associated negatively with subcutaneous fat, but not visceral fat. In addition, testosterone was positively correlated with abdominal muscle regardless of qualitative features such as fat-rich and fat-free.
Histone deacetylase 6 plays an important role in TGF-β-induced murine Treg cell differentiation by regulating cell proliferation
Authors: Lee Ji Hyeon , Kim Hyeong Su , Jang Sung Woong , Lee Gap Ryol 
Published: December 2022

AbstractRegulatory T (Treg) cells maintain immune homeostasis by preventing abnormal or excessive immune responses. Histone deacetylase 6 (HDAC6) regulates expression of Foxp3, and thus, Treg cell differentiation; however, its role in Treg cell differentiation is unclear and somewhat controversial. Here, we investigated the role of HDAC6 in TGF-β-induced murine Treg cells. HDAC6 expression was higher in Treg cells than in other T helper cell subsets. Pharmacological inhibitors of HDAC6 selectively inhibited Treg cell differentiation and suppressive function. A specific HDAC6 inhibitor induced changes in global gene expression by Treg cells. Of these changes, genes related to cell division were prominently affected. In summary, HDAC6 plays an important role in TGF-β-induced murine Treg cell differentiation by regulating cell proliferation.
Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial
Authors: Denkinger Claudia M. , Janssen Maike , Schäkel Ulrike , Gall Julia , Leo Albrecht , Stelmach Patrick , Weber Stefan F. , Krisam Johannes , Baumann Lukas , Stermann Jacek , Merle Uta , Weigand Markus A. , Nusshag Christian , Bullinger Lars , Schrezenmeier Jens-Florian , Bornhäuser Martin , Alakel Nael , Witzke Oliver , Wolf Timo , Vehreschild Maria J. G. T. , Schmiedel Stefan , Addo Marylyn M. , Herth Felix , Kreuter Michael , Tepasse Phil-Robin , Hertenstein Bernd , Hänel Mathias , Morgner Anke , Kiehl Michael , Hopfer Olaf , Wattad Mohammad-Amen , Schimanski Carl C. , Celik Cihan , Pohle Thorsten , Ruhe Matthias , Kern Winfried V. , Schmitt Anita , Lorenz Hanns-Martin , Souto-Carneiro Margarida , Gaeddert Mary , Halama Niels , Meuer Stefan , Kräusslich Hans-Georg , Müller Barbara , Schnitzler Paul , Parthé Sylvia , Bartenschlager Ralf , Gronkowski Martina , Klemmer Jennifer , Schmitt Michael , Dreger Peter , Kriegsmann Katharina , Schlenk Richard F. , Müller-Tidow Carsten 
Published: December 2022

AbstractPatients with cancer are at high risk of severe coronavirus disease 2019 (COVID-19), with high morbidity and mortality. Furthermore, impaired humoral response renders severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines less effective and treatment options are scarce. Randomized trials using convalescent plasma are missing for high-risk patients. Here, we performed a randomized, open-label, multicenter trial (https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001632-10/DE) in hospitalized patients with severe COVID-19 (n = 134) within four risk groups ((1) cancer (n = 56); (2) immunosuppression (n = 16); (3) laboratory-based risk factors (n = 36); and (4) advanced age (n = 26)) randomized to standard of care (control arm) or standard of care plus convalescent/vaccinated anti-SARS-CoV-2 plasma (plasma arm). No serious adverse events were observed related to the plasma treatment. Clinical improvement as the primary outcome was assessed using a seven-point ordinal scale. Secondary outcomes were time to discharge and overall survival. For the four groups combined, those receiving plasma did not improve clinically compared with those in the control arm (hazard ratio (HR) = 1.29; P = 0.205). However, patients with cancer experienced a shortened median time to improvement (HR = 2.50; P = 0.003) and superior survival with plasma treatment versus the control arm (HR = 0.28; P = 0.042). Neutralizing antibody activity increased in the plasma cohort but not in the control cohort of patients with cancer (P = 0.001). Taken together, convalescent/vaccinated plasma may improve COVID-19 outcomes in patients with cancer who are unable to intrinsically generate an adequate immune response.
Social Network Characteristics and Correlations With Cognitive, Psychosocial, and Speech Function and Communication Participation for Adults With Multiple Sclerosis: A Pilot Study
Authors: Feenaughty Lynda 
Published: December 2022

Purpose:
This cross-sectional observational pilot study investigated egocentric social networks for 10 paired sex- and age-matched adults with and without multiple sclerosis (MS). This study also investigated the relationship between social network measures and various disease factors associated with MS. The relationship between social network measures and communication participation restrictions was also examined.

Method:
Participants completed a seven-item social network survey. Social network structure and composition were quantified. The network organization measures (structure analysis) included the total number of members (network size) and extent to which members are connected (network density). The measured characteristics of people around a participant (composition analysis) included the amount of kin relative to network size (proportion of kin), gender variation (gender diversity index), and age variation (standard deviation of age). Standard clinical neuropsychological, psychosocial, and speech metrics quantified processing speed, memory, depression, fatigue, and sentence intelligibility. Measures of communication participation and MS severity were also obtained.

Results:
Matched-pairs tests indicated that the proportion of kin significantly differed between paired participants, whereas all other social network measures were similar. For participants with MS, correlation analyses indicated weak associations between proportion of kin and cognitive, psychosocial, and speech measures. However, strong correlations were found between social network size and processing speed, memory, fatigue, MS severity, and communication participation. Gender diversity index also strongly correlated with depression.

Conclusions:
Results from this pilot study highlight the importance of evaluating egocentric networks in the clinical management of MS, as maintaining nonkin friendships may be difficult for adults with MS making them vulnerable to social isolation. Furthermore, those with small and less diverse networks may experience more severe cognitive and psychosocial problems and limited communication participation.
Characterizing Speech Sound Productions in Bilingual Speakers of Jamaican Creole and English: Application of Durational Acoustic Methods
Authors: León Michelle , Washington Karla N. , McKenna Victoria S. , Crowe Kathryn , Fritz Kristina , Boyce Suzanne 
Published: December 2022

Purpose:
This study examined the speech acoustic characteristics of Jamaican Creole (JC) and English in bilingual preschoolers and adults using acoustic duration measures. The aims were to determine if, for JC and English, (a) child and adult acoustic duration characteristics differ, (b) differences occur in preschoolers' duration patterns based on the language spoken, and (c) relationships exist between the preschoolers' personal contextual factors (i.e., age, sex, and percentage of language [%language] exposure and use) and acoustic duration.

Method:

Data for this cross-sectional study were collected in Kingston, Jamaica, and New York City, New York, United States, during 2013–2019. Participants included typically developing simultaneous bilingual preschoolers (
n
= 120, ages 3;4–5;11 [years;months]) and adults (
n
= 15, ages 19;0–54;4) from the same linguistic community. Audio recordings of single-word productions of JC and English were collected through elicited picture-based tasks and used for acoustic analysis. Durational features (voice onset time [VOT], vowel duration, whole-word duration, and the proportion of vowel to whole-word duration) were measured using Praat, a speech analysis software program.

Results:
JC-English–speaking children demonstrated developing speech motor control through differences in durational patterns compared with adults, including VOT for voiced plosives. Children's VOT, vowel duration, and whole-word duration were produced similarly across JC and English. The contextual factor %language use was predictive of vowel and whole-word duration in English.

Conclusions:
The findings from this study contribute to a foundation of understanding typical bilingual speech characteristics and motor development as well as schema in JC–English speakers. In particular, minimal acoustic duration differences were observed across the post-Creole continuum, a feature that may be attributed to the JC–English bilingual environment.

Supplemental Material:

https://doi.org/10.23641/asha.21760469