bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between media use and poor sleep quality among senior high school students: a cross-sectional study
Authors: Chaveepojnkamjorn Wisit , Srikaew Jutiporn , Satitvipawee Pratana , Pitikultang Supachai , Khampeng Soontaree 
Published: August 2023

Background: Poor sleep quality (PSQ) is an increasing health problem among adolescents. Mobile phones and portable media devices have become a part of children’s lives and may affect their sleep duration and quality. This study aimed to explore the prevalence of PSQ and identify the association between media use and PSQ among adolescents studying in high school grades 10-12. Methods: This cross-sectional study was conducted in central Thailand. A multi-stage sampling technique was used to enroll 777 adolescents from eight schools from August to October 2016. The research instruments comprised factors of demographics and consumption behaviors and the Pittsburgh Sleep Quality Index questionnaire. Multivariable logistic regression was used to calculate adjusted odds ratios (ORadj) and 95% confidence intervals (CI). Results: Prevalence of PSQ was 56.24%. The study subjects were mostly 16-17 years old (67.82%) and female (70.39%). Multivariable logistic regression, after controlling for possible confounders, revealed an increased odds of PSQ among those who used a social media device (OR=1.34, 95%CI=0.97-1.87), and showed a higher proportion of social media use in the PSQ group. Conclusion: A surveillance system to detect media use and PSQ should be conducted accompanied by knowledge sharing on media use among parents, teachers and adolescents. To determine causal relationships, further longitudinal studies will be required to test the association between media users and PSQ. This study may also provide some implications for health promotion on sleep quality of senior high school students.
Design an efficient method for the synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole
Authors: B Srinivas , Koya Prabhakara Rao 
Published: August 2023

A simple, highly efficient and environmentally friendly method has been developed for the synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole by using Gadolinium(III) trifluoromethanesulfonate catalyst and ethanol reflux reaction conditions By using this method. 12 new 2-(1,3-diphenyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazole derivatives were synthesized under optimized reactions conditions. All these new products structures are confirmed by spectral analysis. By this method, we achieved imidazole derivatives with more operational simplicity, short reaction time and good yields (up to 85%).
How do eating disorders can affect the endocrine system? - literature review
Authors: Iwan Karolina , Bielak Alicja , Gryta Jakub , Janczewska Martyna , Kalicka Maria , Kolasa Agata , Krysa Tomasz , Radziejowska Zuzanna , Szklarz Magdalena 
Published: August 2023

Introduction: Eating disorders (ED) are complex psychological disorders with low rates of detection and early intervention. High rates of morbidity and mortality in eating disorders, especially anorexia nervosa (AN), is still continued. ED mostly refers to adolescent and lead to many significant complications, including many changes in endocrine system. Hormonal disorders in AN occur among sex hormones, thyroid hormones, adrenal hormones, growth hormones, as well as the entire hypothalamic-pituitary axis.
Purpose of the study: The aim of this study is to collect and summarize the latest views on endocrine dysregulation in anorexia nervosa and highlights the complications associated with it.
Material and method: Literature review was performed in English different databases, using keywords: eating disorders, anorexia nervosa, menstruation, menses, irregular menstruation, estrogen, bone mineral density, cortisol, hipercortisolemia, insulin, leptin, ghrelin, growth hormone, thyroid, tyrosine.
Results and conclusions: In our systematic review we would like to present the most significant hormone dysregulation in anorexia nervosa and how they can affect the whole organism, such as gonadal axis disregulation, menstrual disorders, bone mineral density, hipercortisolemia, hypoglycemia and other that anorexia nervosa may cause. The phenomenon of eating disorder is becoming more and more frequent – for this reason it is important to put attention to that and be aware of many complication ED can lead to, including hormonal changes.
Psilocybin's Emerging Role in Combating Depressive Disorder
Authors: Jaremek Anna , Kępa Joanna , Kandefer Norbert , Wyszkowski Michał , Grabarczyk Aleksandra , Pawlak Anna , Grad Sylwia , Gregorek Małgorzata , Gregorek Paweł 
Published: August 2023

In this review paper, we delve into the potential applicability of psilocybin - a naturally synthesized psychedelic substance found within select species of fungi, as a prospective avenue for depression treatment. Depression, a widespread psychological malady affecting countless individuals across the globe, often proves stubborn against existing treatment modalities, necessitating exploration into new options. The spotlight has increasingly been cast on psilocybin, thanks to its promising therapeutic capacities for a spectrum of mental health disorders, notably including depression. This article dissects the operational mechanisms of psilocybin, referencing germane clinical trials, and weighing the prospective risks and rewards related to its usage.
Pooled findings from an array of clinical studies hint at the possibility of psilocybin furnishing swift and lasting advantages for managing depression and similar disorders. Trial participants who underwent a combined regimen of psilocybin and psychotherapy recorded enduring alleviation in their anxiety and depressive symptoms. Psilocybin has been observed to trigger modifications in neural activity, predominantly in the brain's default mode network (DMN) and the prefrontal cortex (PFC). These alterations have been correlated with a decrease in self-oriented cognitive processes, an uptick in positive emotional states, and the facilitation of neuroplasticity. When compared with standard antidepressant medications, the symptomatic improvements seen with psilocybin were largely equivalent. Preclinical investigations have also underlined psilocybin's potential in augmenting neural plasticity and neurogenesis, thus hinting at its possible utility in the fields of neurosurgery and neurooncology.
Preliminary evaluation of a multidisciplinary pathway for people who self-harm in acute inpatient mental health care
Authors: Smith Kimberley , Gkika Styliani , Hammond Charlotte , Swift Elaine 
Published: August 2023

Background/aims Inpatient mental health settings are required to provide biopsychosocial interventions to support service users who self-harm. This is important as self-harm has been associated with increased admissions and risk of suicide. A multidisciplinary self-harm pathway was developed in an acute inpatient mental health ward for adult women to help staff support patients who self-harm. The aim of this project was to evaluate the pathway in relation to service user distress, confidence in managing mental health, therapeutic alliances with the ward team and self-harm incidents on the ward. Methods Data were collected from the record-keeping systems and from questionnaires completed before and after the pathway was introduced. Results The pathway was well received by service users and contributed to improvements in distress, confidence and to more effective management of self-harm. Conclusions The self-harm pathway was found to be a useful framework within which to structure psychosocial interventions for self-harm and least restrictive practice.
RADIOLOGICAL CLASSIFICATION OF THE PELVIS: A TOOL FOR TRAUMA SURGERY PLANNING
Authors: Lee K. , Lin J. , Lynch J. , Smith P. 
Published: August 2023

Variations in pelvic anatomy are a major risk factor for misplaced percutaneous sacroiliac screws used to treat unstable posterior pelvic ring injuries. A better understanding of pelvic morphology improves preoperative planning and therefore minimises the risk of malpositioned screws, neurological or vascular injuries, failed fixation or malreduction. Hence a classification system which identifies the clinically important anatomical variations of the sacrum would improve communication among pelvic surgeons and inform treatment strategy.300 Pelvic CT scans from skeletally mature trauma patients that did not have pre-existing posterior pelvic pathology were identified. Axial and coronal transosseous corridor widths at both S1 and S2 were recorded. Additionally, the S1 lateral mass angle were also calculated. Pelvises were classified based upon the sacroiliac joint (SIJ) height using the midpoint of the anterior cortex of L5 as a reference point. Four distinct types could be identified:Type-A – SIJ height is above the midpoint of the anterior cortex of the L5 vertebra.Type-B – SIJ height is between the midpoint and the lowest point of the anterior cortex of the L5 vertebra.Type-C – SIJ height is below the lowest point of the anterior cortex of the L5 vertebra.Type-D – a subgroup for those with a lumbosacral transitional vertebra, in particular a sacralised L5.Differences in transosseous corridor widths and lateral mass angles between classification types were assessed using two-way ANOVAs.Type-B was the most common pelvic type followed by Type-A, Type-C, and Type-D. Significant differences in the axial and coronal corridors was observed for all pelvic types at each level. Lateral mass angles increased from Types-A to C, but were smaller in Type-D.This classification system offers a guide to surgeons navigating variable pelvic anatomy and understanding how it is associated with the differences in transosseous sacral corridors. It can assist surgeons’ preoperative planning of screw position, choice of fixation or the need for technological assistance.
Orthohantavirus infections in humans and rodents in the Yichun region, China, from 2016 to 2021
Authors: Liu Shi-Wen , Li Jian-Xiong , Zou Long , Liu Xiao-Qing , Xu Gang , Xiong Ying , Long Zhong-Er 
Published: August 2023

Background
Rodents are the predominant natural hosts of orthohantavirus and the source of human infection, hemorrhagic fever with renal syndrome (HFRS) caused by orthohantavirus is a severe public health problem in the Yichun region, Jiangxi Province, China. However, little information is known about the infection of orthohantavirus in humans and rodents, and the genetic characteristics of the epidemic orthohantavirus in the region.

Methods
The clinical data of HFRS cases in 2016–2021 was analyzed. Virus infection in rodents was analyzed by orthohantavirus antigen detection using immunofluorescent assay, and the species of orthohantaviruses in rodents and patients were identified by real-time RT-PCR and gene sequencing. The S and M segments of orthohantaviruses from rodents and patients were recovered and analyzed.

Results
A total of 1,573 HFRS cases were reported in the Yichun region from 2016 to 2021, including 11 death cases. HFRS cases peaked twice each year: in winter from November to January and early summer from May to June. Farmers constituted the predominant population suffering from HFRS. The orthohantavirus antigen was identified in five species of rodents: Apodemus agrarius (A. agrarius), Rattus norvegicus (R. norvegicus), Sorex araneus, Rattus losea (R. losea), and Niviventer confucianus (N. confucianus). The real-time RT-PCR test and genetic analysis results showed that Hantaan orthohantavirus (HTNV), Seoul orthohantavirus (SEOV), and Dabieshan orthohantavirus (DBSV) were circulated in the rodents. HTNV, SEOV, and DBSV from the rodents were distantly related to other known orthohantaviruses and belonged to novel genetic lineages. SEOV and HTNV were found in HFRS patients, but 97.8% (90/92) of the infections were caused by HTNV. Winter and early summer peaks were both caused by HTNV. The HTNV sequences recovered from HFRS cases were closely related to those from A. agrarius.

Conclusions
In the Yichun region, the orthohantaviruses transmitted in rodents include HTNV, SEOV, and DBSV, which have obvious genetic characteristics and high genetic diversity. At the same time, this region is an HFRS mixed epidemic area dominated by HTNV, with two peaks every year, which deserves our high attention.
Developing a comprehensive model of home-based formal care for elderly adults in Iran: A study protocol
Authors: Mobasseri Khorshid , Kousha Ahmad , Allahverdipour Hamid , Matlabi Hossein 
Published: August 2023

Background
Due to the increasing Iran’s aging population, designing a home care model is necessary. However, the data on designing the home care model for elderly adults among developing countries are limited. This study will be carried out to develop a formal home-based care model for elderly adults in Iran.

Methods
This multi-method study will include three phases: First, Mixed-methods sequential explanatory study including two steps: One, survey to determine the prevalence of dependence on formal and informal caregivers among people aged ≥ 60 years living in Tabriz metropolis; and two, content analysis approach includes face-to-face, semi-structured interviews with the older adults receiving formal care at home, their caregivers and relevant key informants on the characteristics of care and caregiver, challenges and expectations of standard care. In phase 2, a scoping review will be used to find out the components of home care in other countries, such as care provider organization, caregivers training, and financing. PubMed, Scopus, Web of Science, EMBASE, Google scholar databases and grey literature will be run to retrieve relevant evidence using proper MeSH terms. In phase3, the triangulation method (using the results of the previous phases, reviewing national upstream documents and the focus group discussion) will be done to reach consensus and design the initial model for the Iranian context. In the following, a Delphi study will be conducted on the validation and feasibility of the developed model.

Discussion
The current health infrastructure in Iran is focused on caring for younger people, despite the near future population aging. Most studies have addressed the challenges of geriatric care, but no study has addressed the various dimensions of home care in Iran and how to provide this service to elderly adults. Providing a comprehensive model of home care for the elderly can improve the quality of life and satisfaction of the elderly and their caregivers.
The impact of expanded access to direct acting antivirals for Hepatitis C virus on patient outcomes in Canada
Authors: Chu Cherry , Gomes Tara , Antoniou Tony , Wong William W. L. , Janjua Naveed , Guertin Jason Robert , Schwartz Kevin L. , Feld Jordan , Kwong Jeff , Tadrous Mina 
Published: August 2023

Background
Hepatitis C virus (HCV) has high global prevalence and can lead to liver complications and death. Access to direct-acting antivirals (DAAs) in Canada increased following several policy changes, however the real-world impact of expanded DAA access and increased use of these drugs is unknown.

Objective
We aimed to determine the early change in rates of HCV-related hospitalizations overall and HCV-related hospitalizations with hepatocellular carcinoma (HCC) after expanded DAA access.

Methods
We conducted a population-based time series analysis using national administrative health databases in Canada. Rates of HCV-related hospitalizations and HCV-related hospitalizations with HCC were enumerated monthly between April 2006 and March 2020. We used Autoregressive Integrated Moving Average (ARIMA) models with ramp functions in October 2014 and January 2017 to evaluate the impact of policies to expand DAA access on hospitalization outcomes.

Results
Rates of HCV-related hospitalizations in Canada increased between 2006 and 2014, and gradually declined thereafter. The decrease after October 2014, or the first policy change, was significant (p = 0.0355), but no further change was found after the second policy change in 2017 (p = 0.2567). HCV-related hospitalizations with HCC increased until end of 2013, followed by a plateau, before declining in 2016. No significant shifts were found after the first policy change in 2014 (p = 0.1291) nor the second policy change in 2017 (p = 0.6324). Subgroup analyses revealed that those aged 50–64 and males had observable declines in rates of HCV-related hospitalizations in the year prior to the first policy change.

Conclusions
Expanding DAA access was associated with a drop in HCV-related hospitalizations in the overall Canadian population coinciding with the 2014 policy change. In light of the time required for HCV-related complications to manifest, continued ongoing research examining the real-world effectiveness of DAAs is required.
Nonadherence to anti-tuberculosis treatment, reasons and associated factors among pulmonary tuberculosis patients in the communities in Indonesia
Authors: Lolong Dina Bisara , Aryastami Ni Ketut , Kusrini Ina , Tobing Kristina L. , Tarigan Ingan , Isfandari Siti , Senewe Felly Philipus , Raflizar  , Endah Noer , Sitorus Nikson , Pangaribuan Lamria , Simarmata Oster S. , Ariati Yusniar 
Published: August 2023

Background
Tuberculosis (TB) is the world’s major public health problem. We assessed the proportion, reasons, and associated factors for anti-TB treatment nonadherence in the communities in Indonesia.

Methods
This national coverage cross-sectional survey was conducted from 2013 to 2014 with stratified multi-stage cluster sampling. Based on the region and rural-urban location. The 156 clusters were distributed in 136 districts/cities throughout 33 provinces, divided into three areas. An eligible population of age ≥15 was interviewed to find TB symptoms and screened with a thorax x-ray. Those whose filtered result detected positive followed an assessment of Sputum microscopy, LJ culture, and Xpert MTB/RIF. Census officers asked all participants about their history of TB and their treatment—defined Nonadherence as discontinuation of anti-tuberculosis treatment for <6 months. Data were analyzed using STATA 14.0 (College Station, TX, USA).

Results
Nonadherence to anti-TB treatment proportion was 27.24%. Multivariate analysis identified behavioral factors significantly associated with anti-TB treatment nonadherence, such as smoking (OR = 1.78, 95% CI (1.47–2.16)); place of first treatment received: government hospital (OR = 1.45, 95% CI:1.06–1.99); private hospital (OR = 1.93, 95% CI: 1.38–2.72); private practitioner (OR = 2.24, 95% CI: 1.56–3.23); socio-demographic and TB status included region: Sumatera (OR = 1.44, 95% CI: 1.05–1.98); other areas (OR = 1.84, 95% CI: 1.30–2.61); low level of education (OR = 1.60, 95% CI: 1.27–2.03); and current TB positive status (OR = 2.17, 95% CI: 1.26–3.73).

Conclusions
Nonadherence to anti-TB drugs was highly related to the personal perception of the respondents, despite smoking, current TB status, a place for the first treatment, education, and region. The position of the first TB treatment at the private practitioner was significantly associated with the risk of Nonadherence to treatment.
Permanência, Êxito e Evasão de Estudantes Idosos no NETI-UNAPI
Authors: Koerich Guilherme Henrique , Forcelini Franciele , Mauerwerk Maria Eduarda , Hack Catapan Araci , Merino Giselle 
Published: August 2023

A evasão escolar é um fenômeno complexo e multifatorial, influenciado por aspectos sociais, econômicos, práticas pedagógicas, dentre outros. Este artigo busca analisar a permanência, êxito e evasão dos estudantes idosos em atividades socioeducativas do NETI, uma Universidade Aberta para as Pessoas Idosas (UNAPI). Para tanto, foram utilizados registros de diários de classe digitais, implementados em 2019, e do acompanhamento pedagógico dos estudantes com frequência irregular. A pesquisa foi dividida em cinco etapas: (1) fundamentação teórica, (2) implementação do diário de classe digital, (3) acompanhamento pedagógico; (4) organização dos dados coletados e (5) análise dos dados coletados. Os resultados demonstram que a implementação do diário de classe digital permitiu à equipe pedagógica acompanhar a frequência do estudante e intervir em caso de irregularidades em tempo real. Com isto, foi observada a redução no percentual de evasões, o aumento do êxito e um efeito positivo na retomada do estudante para atividade em curso após o acompanhamento. O principal motivo de frequência irregular e evasão são de ordem pessoal e de saúde. O estudo ainda
identificou a predominância de estudantes do sexo feminino (82,5%), com faixa etária entre 60-69 anos (47,4%), domiciliados majoritariamente em Florianópolis (93,3%).
Effect of ramp slope on intensity thresholds based on correlation properties of heart rate variability during cycling
Authors: Fleitas‐Paniagua Pablo R. , de Almeida Azevedo Rafael , Trpcic Mackenzie , Murias Juan M. , Rogers Bruce 
Published: August 2023

AbstractAn index of heart rate variability (HRV), detrended fluctuation analysis (DFA a1) has gathered interest as a surrogate marker of exercise intensity boundaries. The aim of this report was to examine heart rate variability threshold (HRVT) behavior across different ramp incremental (RI) slopes. Seventeen participants completed a series of three RI (15, 30, and 45 W · min−1 slopes) with monitoring of gas exchange parameters, heart rate (HR) and HRV. HRVT1 was defined as the V̇O2 or HR at which DFA a1 reached 0.75 and the HRVT2 at which these values reached 0.5. HRVTs were compared by Pearson's r, Bland–Altman analysis, ICC3,1, ANOVA, and paired t‐testing. An excellent degree of reliability was seen across all three ramps, with an ICC3,1 of 0.93 and 0.88 for the HRVT1 V̇O2 and HR, respectively, and 0.90 and 0.92 for the HRVT2 V̇O2 and HR, respectively. Correlations between HRVT1/2 of the individual ramps were high with r values 0.84–0.95 for both HR and V̇O2. Bland–Altman differences ranged between −1.4 and 1.2 mL · kg−1 · min−1 and −2 and +2 bpm. Paired t‐testing showed no mean differences between any HRVT1/2 ramp comparisons. Cycling ramp slope does not appear to affect either HRVT1 or HRVT2 in terms of HR or V̇O2.
Bamboo charcoal affects soil properties and bacterial community in tea plantations
Authors: Zhang Si-Hai , Wang Yue , Hu Jin-Jie , Chen Wei-Jia , Wu Jia-Le , Seah Rachel Wan Xin , Zhu Yang-Chun , Guo Zhi-Ping , Chen Jie 
Published: August 2023

Abstract
Bamboo charcoal, a type of manufactured biochar, is produced by pyrolyzing bamboo residue under anoxic conditions. Its beneficial properties in absorption, catalyst support, and agricultural function have attracted significant attention; however, relatively few studies have examined its effects on the soil microbiota. In this study, we analyzed the effects of bamboo charcoal on soil physicochemical properties, enzymes, and microbial community structure in tea plantations and investigated the optimal amount of bamboo charcoal to be added to organic fertilizer. The results show that bamboo charcoal can further increase soil available nitrogen, total and available phosphorus and potassium, organic carbon content, pH, and urease activity. However, only the combined use of bamboo charcoal and organic fertilizer significantly increased total nitrogen, sucrase, and β-glucosidase activities in the soil. Bamboo charcoal also significantly increased the Chao1 and Shannon indices of microbiota diversity in a concentration-dependent manner. The structure of the bacterial community changed significantly after the bamboo charcoal addition, with Proteobacteria, Actinobacteria, and Firmicutes increasing and Acidobacteria decreasing. This study provides fundamental insights into the suitability of bamboo charcoal application for the ecological remediation of diseased soils.