bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Deep Learning–Based Approach for Empirical Modeling of Single-Point Wave Spectra in Open Oceans
Authors: Song Yuhao , Jiang Haoyu 
Published: June 2023

Abstract
Directional wave spectra are of importance for numerous practical applications such as seafaring and ocean engineering. The wave spectral densities at a certain point in the open ocean are significantly correlated to the local wind field and historical remote wind field. This feature can be used to predict the wave spectrum at that point using the wind field. In this study, a convolutional neural network (CNN) model was established to estimate wave spectra at a target point using the wind field from the ERA5 dataset. A geospatial range where the wind could impact the target point was selected, and then the historical wind field data within the range were analyzed to extract the nonlinear quantitative relationships between wind fields and wave spectra. For the spectral densities at a given direction, the wind data along the direction where waves come from were used as the input of the CNN. The model was trained to minimize the mean square error between the CNN-predicted and ERA5 reanalysis spectral density. The data structure of the wind input is reorganized into a polar grid centered on the target point to make the model applicable to different open-ocean locations worldwide. The results show that the model can predict well the wave spectrum shapes and integral wave parameters. The model allows for the prediction of single-point wave spectra in the open ocean with low computational cost and can be helpful for the study of spectral wave climate.

Significance Statement
The directional wave spectra (DWS) describe the distribution of wave energy among different frequencies and directions. They are useful for many marine practical applications. Usually, DWS are modeled using numerical wave models (NWMs) based on wave action balance differential equations. Although contemporary NWMs perform well after years of development, their computational costs are relatively high. The fast-developed artificial intelligence (AI) might provide an alternative solution to this task. In this study, convolutional neural networks are used to model the DWS at some selected points in the open ocean. By “learning” from NWM data, AI can effectively simulate single-point DWS in open oceans with low computational cost, which can serve as a faster data-driven surrogate model in related applications.
Improved Overall Survival of Patients with Pancreatic Cancer through Multiagent Chemotherapy and Increased Rates of Surgical Resection
Authors: Nicolais Laura M. , Mohamed Abdimajid , Macgillivray Dougald , Verdini Nicholas , Inhorn Roger , Dugan Matthew , Hayward Cynthia M. , Fitzgerald Timothy L. 
Published: June 2023

Background Seminal trials have demonstrated improved survival in pancreatic adenocarcinoma with novel multiagent chemotherapy regimens. To understand the clinical ramifications of this paradigm shift, we reviewed our institutional experience. Methods This retrospective cohort study utilized a prospective database at a single institution to study all patients diagnosed with and treated for pancreatic adenocarcinoma between 2000 and 2020. Results 1,572 patients were included of which 36% were diagnosed before (Era 1) and 64% after (Era 2) 2011. Survival improved in Era 2 (Median survival 10 vs 8 months, HR .79; P < .001). The survival advantage for Era 2 was primarily seen in patients with high-risk disease (12 vs10 months, HR .71; P < .001). A similar trend was noted for patients undergoing surgical resection (26 vs 21 months, HR .80; P = .081) and with imminently resectable tumors (19 vs 15 months, HR .88; P = .4); however, this was not statistically significant. There was no survival advantage for patients with stage IV disease (4 vs 4 months). Patients in Era 2 were more likely to undergo surgery (OR 2.78; CI 2.00-3.92, P < .001). This increase was driven primarily by increased surgical resection for those with high-risk disease (42 vs 20%, OR 3.74; P < .001). Discussion/Conclusions This single institutional study showed improved survival after the shift to novel chemotherapy regimens. This was driven by improved survival for patients with high-risk disease and may be due to more effective eradication of microscopic metastatic disease with adjuvant chemotherapy and increased resection rates.
Ongoing Effects of SARS-CoV-2 Infection on Arterial Stiffness in Healthy Adults
Authors: Can Yusuf , Kocayigit Ibrahim , Kocayiğit Havva , Sarıbıyık Çakmak Betul , Şahinöz Mustafa , Akdemir Ramazan 
Published: June 2023

There are limited data on the arterial stiffness changes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The present study evaluated the changes in arterial stiffness in completely healthy patients who had a SARS-CoV-2 infection using the cardio‐ankle vascular index (CAVI). The study included 70 patients with SARS-CoV-2 infection between December 2020 and June 2021. A cardiac evaluation was carried out, including chest X-ray, electrocardiography (ECG), and echocardiography in all patients. Within the 1st month and 7th month CAVI was measured. Mean age was 37.8 ± 10.0 years, and 41/70 were female. Mean height was 168.6 ± 9.5 cm, mean weight 73.2 ± 15.1 kg, and mean body mass index (BMI) of the group was 25.6 ± 4.2, respectively. CAVI results from the right arm were 6.45 ± .95 at 1-month follow-up and 6.68 ± 1.05 at 7 months follow-up (P = .016) and from the left arm were 6.43 ± 1.0 at 1-month follow-up, 6.70 ± 1.05 at 7-month follow-up (P = .005). Our results showed an ongoing injury in the arterial system after healthy SARS-COV-2 patients during 7 months, as represented by CAVI measurements.
Developing health literacy events: a case study of teachers designing health curricula
Authors: Rumenapp Joseph C , Troiano Beverly , Adams Marcine , Moya Jannette , Lawrence Eva , Razfar Aria 
Published: June 2023

Objective: In response to the question ‘how can teachers develop health literacy events that leverage students’ cultural and linguistic resources’, this study highlights how two teachers developed a culturally and linguistically responsive curriculum that sought to promote health literacy. Design: The study details findings from a larger partnership between an urban university and a bilingual urban school in the USA. Researchers and teachers conducted a year-long project oriented towards co-designing a curriculum that integrated students’ cultural and linguistic repertoires with health literacy. Over one academic year, teachers planned, implemented, studied and modified curricular units that drew on students’ cultural and linguistic resources related to health. Setting: The study focuses on two Spanish-English bilingual teachers working in a third-grade (8–9 year olds) dual-language classroom in a multilingual urban community in the midwestern USA. Method: Data collected included classroom conversations, teacher-researcher and university researcher conversations, classroom work and teacher-derived analytic documents. Data were coded and analysed to understand how teachers made sense of what happened within specific health literacy events to develop a single descriptive case study. Results: Three events are focused on demonstrating how teachers developed health literacy by building on students’ pre-existing cultural and linguistic resources. Teachers moved from using teacher-centred forms of nutrition education to using student-developed health content that articulated with health concerns in the community. Conclusion: Using a funds of knowledge approach to integrating health literacy into the curriculum, teachers helped students draw on cultural and linguistic resources, building self-confidence, and developing an interest in gathering evidence and presenting health-related findings.
School leadership that supports health promotion in schools: A systematic literature review
Authors: Adams Donnie , Lok Tan King , Sandmeier Anita , Skedsmo Guri 
Published: June 2023

Objective: Schools are important settings for health promotion. In schools, children and adolescents can be reached regardless of their social background, which represents a unique opportunity for promoting health. Several studies have demonstrated the importance of school leadership in initiating and sustaining health promotion; however, efforts to systematically review the influence of school leadership on school health promotion are still lacking. Hence, this paper analyses empirical studies published in scientific journals on school leadership and health promotion in schools. Design: Systematic literature review. Method: Informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, a review was conducted using two main databases: Web of Science and Scopus, which retrieved 51 eligible articles. Results: The review of these articles resulted in the identification of seven main themes – school leaders’ health; attitudes, knowledge and behaviour; accountability; support from school leaders; shared leadership approaches; capacity building and parent engagement. Conclusion: This systematic literature review expands the literature by highlighting the school leadership factors that promote school health promotion in Oceania, Europe, North America, South America, Africa and Asia continents. Future systematic literature reviews could explore studies and different aspects of health promotion by teachers, especially in the Asian context.
Impella 5.5 support before, during, and after surgical ventricular septal defect repair: A bridge continuum
Authors: Dimarakis Ioannis , Adcox Mackenzie , Pal Jay D , Khorsandi Maziar 
Published: June 2023

Introduction Post-infarction ventricular septal defect formation remains a formidable mechanical complication of acute myocardial infarction associated with increased morbidity and mortality. Case presentation We describe the case of a 72-year-old male who was admitted with post-myocardial infarction ventricular septal defect and cardiogenic shock. Discussion Impella 5.5 with SmartAssist as temporary left ventricular assist device provided sufficient support throughout multiple bridging episodes including failed percutaneous repair and subsequent definitive surgical repair. Contemporary management of post-infarction ventricular septal defect is discussed.
MRI-based radiomics model for distinguishing Stage I endometrial carcinoma from endometrial polyp: a multicenter study
Authors: Shen Liting , Du Lixin , Hu Yumin , Chen Xiaojun , Hou Zujun , Yan Zhihan , Wang Xue 
Published: June 2023

Background Patients with early endometrial carcinoma (EC) have a good prognosis, but it is difficult to distinguish from endometrial polyps (EPs). Purpose To develop and assess magnetic resonance imaging (MRI)-based radiomics models for discriminating Stage I EC from EP in a multicenter setting. Material and Methods Patients with Stage I EC (n = 202) and EP (n = 99) who underwent preoperative MRI scans were collected in three centers (seven devices). The images from devices 1–3 were utilized for training and validation, and the images from devices 4–7 were utilized for testing, leading to three models. They were evaluated by the area under the receiver operating characteristic curve (AUC) and metrics including accuracy, sensitivity, and specificity. Two radiologists evaluated the endometrial lesions and compared them with the three models. Results The AUCs of device 1, 2_ada, device 1, 3_ada, and device 2, 3_ada for discriminating Stage I EC from EP were 0.951, 0.912, and 0.896 for the training set, 0.755, 0.928, and 1.000 for the validation set, and 0.883, 0.956, and 0.878 for the external validation set, respectively. The specificity of the three models was higher, but the accuracy and sensitivity were lower than those of radiologists. Conclusion Our MRI-based models showed good potential in differentiating Stage I EC from EP and had been validated in multiple centers. Their specificity was higher than that of radiologists and may be used for computer-aided diagnosis in the future to assist clinical diagnosis.
Oximetry at admission as a predictor of tomographic and functional impairment after 3–6 months in hospitalized patients with COVID-19
Authors: Villar Pedro Maximink Esteves , Mendes Paulo Roberto Araújo , Kiyota Tatiana Alves , Engleitner Henrique Alcântara , Tamesawa Carolina Salem , Morello Mayara Magalhães , Basso Nayara Nobre , Arruda Lucas Fileti , Vian Bruna Scharlack , Ratti Lígia dos Santos Roceto , de Oliveira Laís Bacchin , Lima Ana Lucia Cavallaro Baraúna , Ceccato Hugo Dugolin , Silva Julian Furtado , Villalba Wander de Oliveira , Conterno Lucieni de Oliveira , Resende Mariângela Ribeiro , Pereira Mônica Corso 
Published: June 2023

Objective To investigate characteristics that may be associated with radiologic and functional findings following discharge in patients with severe coronavirus disease 2019 (COVID-19). Methods This single-center, prospective, observational cohort study comprised patients aged >18 years who were hospitalized with COVID-19 pneumonia, between May and October 2020. After 3 to 6 months of discharge, patients were clinically evaluated and underwent spirometry, a 6-minute walk test (6MWT), and chest computed tomography (CT). Statistical analysis was performed using association and correlation tests. Results A total of 134 patients were included (25/114 [22%] were admitted with severe hypoxemia). On the follow-up chest CT, 29/92 (32%) had no abnormalities, regardless of the severity of the initial involvement, and the mean 6MWT distance was 447 m. Patients with desaturation on admission had an increased risk of remaining CT abnormalities: patients with SpO2 between 88 and 92% had a 4.0-fold risk, and those with SpO2 < 88% had a 6.2-fold risk. The group with SpO2 < 88% also walked shorter distances than patients with SpO2 between 88 and 92%. Conclusion Initial hypoxemia was found to be a good predictor of persistent radiological abnormalities in follow-up and was associated with low performance in 6MWT.
Neurological and psychiatric comorbidities of migraine: Concepts and future perspectives
Authors: Pelzer Nadine , de Boer Irene , van den Maagdenberg Arn M.J.M. , Terwindt Gisela M. 
Published: June 2023

Background This narrative review aims to discuss several common neurological and psychiatric disorders that show comorbidity with migraine. Not only can we gain pathophysiological insights by studying these disorders, comorbidities also have important implications for treating migraine patients in clinical practice. Methods A literature search on PubMed and Embase was conducted with the keywords “comorbidity”, “migraine disorders”, “migraine with aura”, “migraine without aura”, “depression”, “depressive disorders”, “epilepsy”, “stroke”, “patent foramen ovale”, “sleep wake disorders”, “restless legs syndrome”, “genetics”, “therapeutics”. Results Several common neurological and psychiatric disorders show comorbidity with migraine. Major depression and migraine show bidirectional causality and have shared genetic factors. Dysregulation of both hypothalamic and thalamic pathways have been implicated as a possibly cause. The increased risk of ischaemic stroke in migraine likely involves spreading depolarizations. Epilepsy is not only bidirectionally related to migraine, but is also co-occurring in monogenic migraine syndromes. Neuronal hyperexcitability is an important overlapping mechanism between these conditions. Hypothalamic dysfunction is suggested as the underlying mechanism for comorbidity between sleep disorders and migraine and might explain altered circadian timing in migraine. Conclusion These comorbid conditions in migraine with distinct pathophysiological mechanisms have important implications for best treatment choices and may provide clues for future approaches.
Properties of poly (lactic Acid)/ hydroxyapatite biocomposites for 3D printing feedstock material
Authors: Begum Sabana Ara , Krishnan P Santhana Gopala , Kanny Krishnan 
Published: June 2023

In this study, biocomposites as feedstock material for 3D printing were produced by poly (lactic acid) (PLA) as a polymer matrix and Hydroxyapatite (HAP) as reinforcing filler for potential use in biomedical applications. Biocomposites filament from PLA and different HAP content varying from 1–10 wt% were prepared from extrusion and then injection moulding process. The impact of HAP loading on the properties of biocomposites was investigated for crystallinity, density, hardness, tensile, impact, flexural, melt flow index (MFI), thermal properties and biomineralization studies. The formation of PLA/HAP biocomposites was confirmed by fourier transform infrared spectroscopy (FTIR). The hydrophilicity of the biocomposites was studied by contact angle analysis. Dispersion of HAP into PLA matrix was confirmed by scanning electron microscopy (SEM) and optical microscopy. The HAP addition increased the density of the composites. From mechanical analysis PLA/HAP composites containing 1–5 wt% showed an increase in tensile modulus. The Shore D hardness of the composites increased with increase in wt% of HAP content. The maximum hardness was achieved for 10 wt% of HAP content i.e., 87 ± 0.1, which is about 6.1% more than neat PLA. The MFI increased with rise in HAP content that gives a positive opinion of reinforcing PLA composites without deteriorating the processability. The hydrophilicity of the biocomposites was slightly increased after the addition of HAP. From thermal analysis it was concluded that the thermal stability of the biocomposites increased when compared with neat PLA. From the Biomineralization studies formation of apatite layer on PLA composites was confirmed by SEM analysis.
Investigating the effect of rail profile deviation on hunting instability of high-speed railway vehicle under multi-parameter coupling
Authors: Hou Maorui , Yang Guang , Chen Bingzhi , Liu Fengshou , Wang Nashuyuan 
Published: June 2023

Small changes to wheel-rail profiles can have a significant impact on the equivalent conicity and vehicle dynamics. Previous research has focused mostly on worn wheels, however, with little attention to different types of rail profile deviation and their influences on vehicle dynamics. Therefore, the specific objective of this paper is to investigate the individual and combined influences of various rail profiles and multi-parameter couplings on the hunting instability of railway vehicles. This paper first obtains the distribution law of rail profile deviation from a statistical analysis of several rail profiles with long-term measurements. Then, the equivalent conicity of rail profiles that match the studied wheel profiles, gauges and wheelback distances is compared. The dynamic model for the vehicle has been established. Finally, the measured rail profiles and wheel profiles, as well as the combinations of the gauges, wheelback distances, friction coefficients and key suspension characteristics are integrated into the simulation model to analyze the atypical phenomenon of the carbody hunting and the bogie hunting. According to the findings, rail profile deviation has a significant impact on equivalent conicity and the evaluation of vehicle stability when subjected to multi-parameter coupling, particularly for worn wheels. Therefore, strict limits of rail profile deviation have to be considered in track maintenance for vehicles running at speeds of 300 km/h or higher.
Withania somnifera Alter BCL2/Bax signaling and trigger apoptosis of MCF-7 and MDA-MB231 breast cancer cells exposed to γ-radiation
Authors: Maarouf Rokaya E , Azab Khaled Shaaban , El Fatih Neama M , Helal Hamed , Rashed Laila 
Published: June 2023

Treatment strategies encompass synchronization of more than one therapy with specific dependence on zeroing side effects of natural products that might represent a niche in the continuous struggle against cancer. Thus, this study aimed at assessing the role of Withania somnifera; WS (Ashwagandha) in forcing MCF7 or MDA-MB 231 irradiated breast cancer cells to outweigh the route of programmed cell death. We check to what extent SIRT1-BCL2/Bax signaling pathway was interrelated to form apoptotic cancer cells. MDA or MCF7 cells are categorized into four groups: gp1, Control (C): MDA-MB-231 or MCF7 cells not treated with WS or exposed to γ-rays, gp2 (WS): cells challenged with WS for MDA-MB-231 or MCF7 cells respectively, gp3: irradiated (R) MDA-MB-231 or MCF7 cells exposed to γ-rays (4 Gy; one shot) and gp4 WS and irradiated (WS + R): cells challenged with WS as in gp2 and exposed to gamma rays as in gp3. The results revealed that, WS established IC50 equivalent to 4897.8 μg/ml in MDA-MB-231 cells or equivalent to 3801.9 μg/ml in MCF7 cells. The flowcytometric analysis (Annexin V and cell cycle) showed that WS induces apoptosis at pre-G phase and induces cell arrest at G2/M and preG1 phases for MDA-MB-231 and at the preG1 for MCF7 cells. Furthermore, the WS + R group of cells (MDA-MB-231 and MCF7) showed significant increases in the expression of SIRT1, and BCL2 and a decrease in BAX compared with WS or R group. It could be concluded that WS has an anti-proliferative action on MDA-MB-231 and MCF7 cells because of its capability to enhance apoptosis.
Serum Zinc Levels in Preterm Newborns and its Relation with Retinopathy of Prematurity
Authors: Mishra Sukriti , Shrivastava Neha , Agrawal Amit , Shrivastava Jyotsna 
Published: June 2023

Background With the increased survival of preterm babies, retinopathy of prematurity (ROP) has become the leading cause of preventable childhood blindness. It is caused by oxidative damage to the immature retina and zinc may help in the prevention of ROP owing to its antioxidant properties. Objective To measure serum zinc levels in preterm neonates and study its association with the development of ROP. Methods A total of 360 preterm neonates of gestational age between 28 completed weeks to <37 weeks were included in this observational cross-sectional study. Serum zinc levels of the neonates aging <24 hours of life were measured at the time of admission in NICU by spectrophotometry. Taking the reference range of serum zinc levels between 70 to 150 mcg/dL babies were arbitrarily divided into 2 groups (<70 and >70 mcg/dL). ROP screening was done at appropriate postnatal age by indirect ophthalmoscopy. The results were analyzed by the SPSS software version. Results The mean serum zinc level was 114.99±54.47 mcg/dL. The overall prevalence of ROP was 26%; of which, 10% of neonates had severe ROP (≥stage 3). A significant association was found between gestational age and birth weight with ROP. Oxygen supplementation, respiratory distress syndrome, surfactant use, antibiotic use >7 days, and low serum zinc levels (<70 mcg/dL) were significant risk factors on univariate analysis and after multivariate analysis, gestational age, surfactant use, and low serum zinc levels (<70 mcg/dL) came out to be independent risk factors for ROP. Conclusion There was a statistically significant association of low serum zinc levels with the development of ROP and it was independent of other risk factors associated with ROP.