bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular health and cognitive outcomes: Findings from a biracial population‐based study in the United States
Authors: Dhana Anisa , DeCarli Charles S. , Dhana Klodian , Desai Pankaja , Holland Thomas M. , Evans Denis A. , Rajan Kumar B. 
Published: August 2023

AbstractINTRODUCTIONThe aim of this study was to evaluate the association of cardiovascular health (CVH) with cognitive outcomes, including incident Alzheimer's dementia, rate of cognitive decline, and measures of brain injury and structure.METHODSThis study consisted of 1702 Black or African American and White participants living in the south side of Chicago, Illinois, and enrolled in the Chicago Health and Aging Project, a population‐based cohort since 1993. CVH was based on seven risk factors, including diet, physical activity, body mass index, smoking, dyslipidemia, hypertension, and diabetes.RESULTSIn a multivariable‐adjusted model, CVH was associated with a lower risk of Alzheimer's dementia. The hazard ratio per 1 additional point in CVH score was 0.84 (95% CI 0.76, 0.94). CVH was also associated with a slower rate of cognitive decline and less volume (injury) in white matter hyperintensities.DISCUSSIONPromoting CVH in communities with Black residents may lower the future risk of Alzheimer's dementia.
Chiroptical Amplification of Induced Circularly Polarized Luminescence in Nucleotide‐Templated Supramolecular Polymer
Authors: Das Angshuman , Ghosh Saikat , George Subi J. 
Published: August 2023

AbstractEfficient circularly polarized luminescence (CPL) from purely organic molecules holds great promise for applications in displays, sensing, and bioimaging. However, achieving high dissymmetry values (glum) from organic chromophores remains a significant challenge. Herein, we present a bioinspired approach using adenosine triphosphate (ATP)‐triggered supramolecular polymerization of a naphthalene diimide‐derived monomer (ANSG) to induce CPL with a remarkable glum value of 1.1×10−2. The ANSG molecules undergo a templated, chiral self‐assembly through a cooperative growth mechanism in the presence of ATP, resulting in scrolled nanotubes with aggregation‐induced enhanced emission (AIEE) and induced CPL. Furthermore, we demonstrate the concept of chiroptical amplification of induced CPL by efficiently amplifying asymmetry using a mixture of chiral ATP and achiral pyrophosphate. This innovative approach opens numerous opportunities in the emerging field of circularly polarized luminescence.
A Single‐Crystal Monomer to Single‐Crystal Polymer Reaction Activated by a Triplet Excimer in a Zipper Mechanism
Authors: Long Lanxin , Medina Rivero Samara , Sun Fanxi , Wang Dongsheng , Chekulaev Dimitri , Tonnelé Claire , Casanova David , Casado Juan , Zheng Yonghao 
Published: August 2023

AbstractA combined experimental and theoretical study focused on the elucidation of the polymerization mechanism of the crystal monomer to crystal polymer reaction of a bisindenedione compound in the solid state. The experimental description and characterization of the polymer product have been reported elsewhere and, in this article, we address the first detailed description of the polymerization process. This reaction pathway consists of the initial formation of a triplet excimer state that relaxes to an intermolecularly bonded triplet state that is the starting point of the propagation step of the polymerization. The overall process can be visualized in the monomer starting state as an open zipper in which a cursor or slider is formed by light absorption and the whole zipper is then closed by propagation of the cursor. To this end, variable‐temperature electron spin resonance (ESR), femtosecond transient absorption spectroscopy, and vibrational Raman spectroscopic data have been implemented in combination with quantum chemical calculations. The presented mechanistic insight is of great value to understand the intricacies of such an important reaction and to envisage and diversify the products produced thereof.
Metal‐Free Directed Site‐Selective Csp3‐H Borylation of Saturated Cyclic Amines
Authors: Kumar Someswara Ashwathappa Puneeth , Higashi Takuya , Desrosiers Vincent , Omaña Alvaro A. , Fontaine Frédéric‐Georges 
Published: August 2023

AbstractThe borylation of Csp3−H bonds is a challenging transformation that is typically restricted to transition metal catalysis. Herein, we report the site‐selective metal‐free Csp3−H borylation of saturated cyclic amines. It is possible to selectively borylate piperidine derivatives at the α or β positions according to the reaction conditions. The mechanism was supported by NMR spectroscopy, calorimetry experiments and density functional theory (DFT) computations. It suggests that the piperidine is dehydrogenated by complexation with BBr3 to produce an enamine intermediate, which is in turn borylated at either the α or β position according to the reaction conditions.
Hydrodeoxygenation of Oxygen‐Containing Aromatic Plastic Wastes to Liquid Organic Hydrogen Carriers
Authors: Wei Junde , Zhu Mengmeng , Liu Ben , Wang Nan , Liu Jieyi , Tomishige Keiichi , Liu Sibao , Liu Guozhu 
Published: August 2023

AbstractTo address the global plastic pollution issues and the challenges of hydrogen storage and transportation, we report a system, based on the hydrodeoxygenation (HDO) of oxygen‐containing aromatic plastic wastes, from which organic hydrogen carriers (LOHCs) can be derived. We developed a catalytic system comprised of Ru‐ReOx/SiO2+HZSM‐5 for direct HDO of polycarbonate (PC), polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polyphenylene oxide (PPO), and their mixtures, to cycloalkanes as LOHCs, with high yields up to 99 %, under mild reaction conditions. The theoretical hydrogen storage capacity reaches ca. 5.74 wt%. The reaction pathway involves depolymerization of PC into C15 aromatics and C15 monophenols by direct hydrogenolysis of the C−O bond between the benzene ring and ester group, and subsequent parallel hydrogenation of C15 aromatics and HDO of C15 monophenols. HDO of cyclic alcohol is the rate‐determining step. The active site is Ru metallic nanoparticles with partially covered ReOx species. The excellent performance is attributed to the synergetic effect of oxophilic ReOx species and Ru metallic sites for C−O hydrogenolysis and hydrogenation, and the promotion effect of HZSM‐5 for dehydration of cyclic alcohol. The highly efficient and stable dehydrogenation of cycloalkanes over Pt/γ‐Al2O3 confirms that HDO products can act as LOHCs.
Crossover Sorption of C2H2/CO2 and C2H6/C2H4 in Soft Porous Coordination Networks
Authors: Shivanna Mohana , Otake Ken‐ichi , Hiraide Shotaro , Fujikawa Takao , Wang Ping , Gu Yifan , Ashitani Hirotaka , Kawaguchi Shogo , Kubota Yoshiki , Miyahara Minoru T. , Kitagawa Susumu 
Published: August 2023

AbstractPorous sorbents are materials that are used for various applications, including storage and separation. Typically, the uptake of a single gas by a sorbent decreases with temperature, but the relative affinity for two similar gases does not change. However, in this study, we report a rare example of “crossover sorption,” in which the uptake capacity and apparent affinity for two similar gases reverse at different temperatures. We synthesized two soft porous coordination polymers (PCPs), [Zn2(L1)(L2)2]n (PCP‐1) and [Zn2(L1)(L3)2]n (PCP‐2) (L1= 1,4‐bis(4‐pyridyl)benzene, L2=5‐methyl‐1,3‐di(4‐carboxyphenyl)benzene, and L3=5‐methoxy‐1,3‐di(4‐carboxyphenyl)benzene). These PCPs exhibits structural changes upon gas sorption and show the crossover sorption for both C2H2/CO2 and C2H6/C2H4, in which the apparent affinity reverse with temperature. We used in situ gas‐loading single‐crystal X‐ray diffraction (SCXRD) analysis to reveal the guest inclusion structures of PCP‐1 for C2H2, CO2, C2H6, and C2H4 gases at various temperatures. Interestingly, we observed three‐step single‐crystal to single‐crystal (sc‐sc) transformations with the different loading phases under these gases, providing insight into guest binding positions, nature of host–guest or guest‐guest interactions, and their phase transformations upon exposure to these gases. Combining with theoretical investigation, we have fully elucidated the crossover sorption in the flexible coordination networks, which involves a reversal of apparent affinity and uptake of similar gases at different temperatures. We discovered that this behaviour can be explained by the delicate balance between guest binding and host–guest and guest‐guest interactions.
Mixed‐metal Ionothermal Synthesis of Metallophthalocyanine Covalent Organic Frameworks for CO2 Capture and Conversion
Authors: Seob Song Kyung , Fritz Patrick W. , Abbott Daniel F. , Nga Poon Lok , Caridade Cristiano M. , Gándara Felipe , Mougel Victor , Coskun Ali 
Published: August 2023

AbstractPhthalocyanines (PCs) are intriguing building blocks owing to their stability, physicochemical and catalytic properties. Although PC‐based polymers have been reported before, many suffer from relatively low stability, crystallinity, and low surface areas. Utilizing a mixed‐metal salt ionothermal approach, we report the synthesis of a series of metallophthalocyanine‐based covalent organic frameworks (COFs) starting from 1,2,4,5‐tetracyanobenzene and 2,3,6,7‐tetracyanoanthracene to form the corresponding COFs named M‐pPPCs and M‐anPPCs, respectively. The obtained COFs followed the Irving–Williams series in their metal contents, surface areas, and pore volume and featured excellent CO2 uptake capacities up to 7.6 mmol g−1 at 273 K, 1.1 bar. We also investigated the growth of the Co‐pPPC and Co‐anPPC on a highly conductive carbon nanofiber and demonstrated their high catalytic activity in the electrochemical CO2 reduction, which showed Faradaic efficiencies towards CO up to 74 % at −0.64 V vs. RHE.
Effect of GO‐TiO2 to waterborne epoxy resin on microstructure and anti‐corrosion properties
Authors: Wan Tao , Wang Bo , Wei Shicheng , Yu Kailun , Wang Yujiang , Liang Yi , Huang Wei , Chen Hao , Jiao Zhongyuan 
Published: August 2023

AbstractTo enhance the anti‐corrosion of the waterborne epoxy resin coating, we filled GO‐TiO2 into the coating with ultrasound and stirring method. Results show that coatings rendered optimum properties at GO‐TiO2 content of 0.4 wt% with a hardness of 3H and rate of thermal weight loss reduce 8.3 wt%. After immersion for 30 days, coating exhibited water absorption ratio of merely 11.25% and open circuit potential of −0.871 V. After 1000 h of scratch‐neutral salt spray test, no obvious signs of corrosion were observed on surface. Moreover, Electrochemical results demonstrated that maximum impedance modulus of 0.4GO‐TiO2 coating was 2.18 × 106 Ω cm2, corresponding to superior corrosion resistance. What is more, anticorrosion mechanism was discussed. In conclusion, Filling GO‐TiO2 improved mechanical properties, thermal stability and corrosion resistance of waterborne epoxy resin coatings.
Predicting sugar intake using an extended theory of planned behavior in a sample of adolescents: The role of habit and self‐control
Authors: Phipps Daniel J. , Hagger Martin S. , Hamilton Kyra 
Published: August 2023

AbstractIntroductionHigh levels of sugar intake are associated with multiple maladaptive health outcomes in adult and younger populations. Identifying the psychological determinants of sugar intake in adolescents, and the processes involved, may help identify potentially modifiable targets and inform intervention development. We tested the predictions of an extended theoretical model based on the theory of planned behavior (TPB), which specified social cognition constructs, habit, and self‐control as correlates of sugar intake in an adolescent sample.MethodsAdolescents aged 12 to 14 years (N = 88) recruited via a survey panel company and consenting to participate in the study completed online self‐report measures of constructs from the TPB alongside measures of habit and self‐control. One month later, participants completed a follow‐up measure of free‐sugar intake. Hypothesized effects of our proposed extended model were tested using partial least squares structural equation modeling.ResultsWe found statistically significant effects of attitude, subjective norm, and perceived behavioral control on sugar intake intentions. We also found significant effects of habit and self‐control on sugar intake measured at follow‐up, but no effect for intention. Perceived behavioral control moderated the intention–behavior relationship such that intention effects on behavior were larger when perceived behavioral control was high. However, self‐control did not moderate the intention–behavior relationship.ConclusionResults indicate that sugar intake in this sample was a function of habits and self‐control, and the effect of sugar intake intentions was conditional on perceived behavioral control. Results contribute to an evidence base of determinants and associated processes that relate to sugar intake in adolescents and may signal potentially modifiable targets for intervention.
Stemming the tide: Does climate risk affect M&A performance?
Authors: Lodh Suman , Deshmukh Nitin , Rohani Alireza 
Published: August 2023

AbstractWe examine the effect of climate change risks (CCR) on firms' decision of engaging in mergers and acquisitions (M&A) and M&A performance. In this study we use the responses by firms on ‘climate change‐related risks and opportunities’ of the Carbon Disclosure Project (CDP) survey and 1372 deals of US listed firms during 2010–2020. Consistent with risk vulnerability theory, our evidence indicates that firms with higher CCR have a lower probability of engaging in M&As. After controlling for possible endogeneity, our results also indicate that if acquirers with higher climate change risks choose to engage in M&A, it significantly reduces the announcement returns. These findings suggest that extant measures of climate change risks should be rethought when evaluating M&A efficiency. More broadly, our paper provides causal evidence that managers need to integrate CCR into their formal risk management systems to avoid unsuccessful M&As.
The Phytochemical Tactics for Battling Antibiotic Resistance in Microbes: Secondary Metabolites and Nano Antibiotics Methods
Authors: Habib Adam Mujahid , Tandon Nitin , Singh Iqubal , Tandon Runjhun 
Published: August 2023

AbstractOne of the most serious threats to human health is antibiotic resistance, which has left the world without effective antibiotics. While continuous research and inventions for new antibiotics are going on, especially those with new modes of action, it is unlikely that this alone would be sufficient to win the battle. Furthermore, it is also important to investigate additional approaches. One such strategy for improving the efficacy of existing antibiotics is the discovery of adjuvants. This review has collected data from various studies on the current crisis and approaches for combating multi‐drug resistance in microbial pathogens using phytochemicals. In addition, the nano antibiotic approaches, are discussed, highlighting the high potentials of essential oils, alkaloids, phenolic compounds, and nano antibiotics in combating antibiotic resistance.
Comparative Chemical Composition and Acetylcholinesterase (AChE) Inhibitory Potential of Cinnamomum camphora and Cinnamomum tamala
Authors: Rawat Avneesh , Bhatt Divya , Kholiya Sushma , Chauhan Amit , Bawankule Dnyaneshwar Umrao , Chanotiya Chandan Singh , Padalia Rajendra Chandra 
Published: August 2023

AbstractCinnamomum species have applications in the pharmaceutical and fragrance industry for wide biological and pharmaceutical activities. The present study investigates the chemical composition of the essential oils extracted from two species of Cinnamomum namely C. tamala and C. camphora. Chemical analysis showed E‐cinnamyl acetate (56.14 %), E‐cinnamaldehyde (20.15 %), and linalool (11.77 %) contributed as the major compounds of the 95.22 % of C. tamala leaves essential oil found rich in phenylpropanoids (76.96 %). C. camphora essential oil accounting for 93.57 % of the total oil composition was rich in 1,8‐cineole (55.84 %), sabinene (14.37 %), and α‐terpineol (10.49 %) making the oil abundant in oxygenated monoterpenes (70.63 %). Furthermore, the acetylcholinesterase inhibitory activity for both the essential oils was carried out using Ellman's colorimetric method. The acetylcholinesterase inhibitory potential at highest studied concentration of 1 mg/mL was observed to be 46.12±1.52 % for C. tamala and 53.61±2.66 % for C. camphora compared to the standard drug physostigmine (97.53±0.63 %) at 100 ng/ml. These multiple natural aromatic and fragrant characteristics with distinct chemical compositions offered by Cinnamon species provide varied benefits in the development of formulations that could be advantageous for the flavor and fragrance industry.
Linking perceived social support, career adaptability, and innovative behavior: A two‐wave study
Authors: Rençber İbrahim , Paşaoğlu Baş Didem 
Published: August 2023

AbstractBased on the career construction model of adaptation, this study examined the relationships of career adaptability with measures of adaptivity, and adaptation results. Specifically, we investigated the link among perceived social support, career adaptability, and innovative behavior in the Turkish context. Data were collected from 171 employees. Results indicated that perceived social support positively affected career adaptability, as expected. Contrary to expected, there was no significant relationship between innovative behavior and career adaptability and social support. In addition, career adaptability did not act as a mediator in the association of social support and innovative behavior. Implications and directions for future research were discussed.
Dearomatization of C6 Aromatic Hydrocarbons by Main Group Complexes
Authors: Zhu Huaiyuan , Fujimori Shiori , Kostenko Arseni , Inoue Shigeyoshi 
Published: August 2023

AbstractThe dearomatization reaction is a powerful method for transformation of simple aromatic compounds to unique chemical architectures rapidly in synthetic chemistry. Over the past decades, the chemistry in this field has evolved significantly and various important organic compounds such as crucial bioactive molecules have been synthesized through dearomatization. In general, photochemical conditions or assistance by transition metals are required for dearomatization of rigid arenes. Recently, main‐group elements, especially naturally abundant elements in the Earth's crust, have attracted attention as they have low toxicity and are cost‐effective compared to the late transition metals. In recent decades, a variety of low‐valent main‐group molecules, which enable the activation of stable aromatic compounds under mild conditions, have been developed. This minireview highlights the developments in the chemistry of dearomatization of C6 aromatic hydrocarbons by main‐group compounds leading to the formation of seven‐membered EC6 (E=main‐group elements) ring or cycloaddition products.
Copper Nitrate‐Mediated Selective Bond Cleavage of Alkynes: Diverse Synthesis of Isoxazoles†
Authors: Liu Jianan , Zhou Kaijing , Sun Shaobo , Gao Mingchun , Xu Bin 
Published: August 2023

Comprehensive SummaryAn unprecedented copper nitrate‐mediated bond cleavage of alkynes was developed for the modular synthesis of isoxazoles, where either C—S bond or C≡C triple bond was cleaved selectively. Substituents attached to the C≡C triple bonds could differentiate the chemical bonds cleavage and reaction pathways disparately. Various transformations of products illustrate promising applications of the given protocols.
Evaluating cancer cell line and patient‐derived xenograft recapitulation of tumor and non‐diseased tissue gene expression profiles in silico
Authors: Williams Avery S. , Wilk Elizabeth J. , Fisher Jennifer L. , Lasseigne Brittany N. 
Published: August 2023

AbstractBackgroundPreclinical models like cancer cell lines and patient‐derived xenografts (PDXs) are vital for studying disease mechanisms and evaluating treatment options. It is essential that they accurately recapitulate the disease state of interest to generate results that will translate in the clinic. Prior studies have demonstrated that preclinical models do not recapitulate all biological aspects of human tissues, particularly with respect to the tissue of origin gene expression signatures. Therefore, it is critical to assess how well preclinical model gene expression profiles correlate with human cancer tissues to inform preclinical model selection and data analysis decisions.AimsHere we evaluated how well preclinical models recapitulate human cancer and non‐diseased tissue gene expression patterns in silico with respect to the full gene expression profile as well as subsetting by the most variable genes, genes significantly correlated with tumor purity, and tissue‐specific genes.MethodsBy using publicly available gene expression profiles across multiple sources, we evaluated cancer cell line and patient‐derived xenograft recapitulation of tumor and non‐diseased tissue gene expression profiles in silico.ResultsWe found that using the full gene set improves correlations between preclinical model and tissue global gene expression profiles, confirmed that glioblastoma (GBM) PDX global gene expression correlation to GBM tumor global gene expression outperforms GBM cell line to GBM tumor global gene expression correlations, and demonstrated that preclinical models in our study often failed to reproduce tissue‐specific expression. While including additional genes for global gene expression comparison between cell lines and tissues decreases the overall correlation, it improves the relative rank between a cell line and its tissue of origin compared to other tissues. Our findings underscore the importance of using the full gene expression set measured when comparing preclinical models and tissues and confirm that tissue‐specific patterns are better preserved in GBM PDX models than in GBM cell lines.ConclusionFuture studies can build on these findings to determine the specific pathways and gene sets recapitulated by particular preclinical models to facilitate model selection for a given study design or goal.