bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between second-trimester of pregnancy ultrasound measurements of cervical length and the gestational age, weight, and APGAR score at delivery
Authors: Shabani Azade , Jalalvand Dina , Naeji Zahra , Naghdi Elnaz , Moghaddam Amin Momeni , Zargarzadeh Nikan , Shaw Ina 
Published: January 2023

Abstract
Introduction: Infant mortality is highest in preterm births. Cervical length may indicate early preterm delivery, according to studies. We assessed cervical length, gestational age, birth weight, and delivery Apgar scores.
Methods: This research included 100 women bearing 100 live foetuses (mean maternal age: 29.42±6.26 years, mean gestational range 18-20 weeks). Transvaginal ultrasound measured cervical length in all women. Birth weight, gestational age, and Apgar scores were recorded.
Results: 0% had cervical length less than 15 mm, 9% 15-25 mm, 75% 25-35 mm, and 16% >35 mm. ANOVA showed a significant relationship between cervical length classification and gestational age (p=0.031) and birth weight (p=0.001), but not Apgar scores (p=0.35) or gestational age at birth (p=0.29). Birth weight correlated significantly (p=0.04).
Conclusions: Cervical length screening during the second trimester should be regular in selected nations or areas to decrease premature labour.
Utilization of Sexual and Reproductive Health Services and Associated Factors Among the Youth in Lira City West, Northern Uganda: A Cross Sectional Study
Authors: Murungi Tom , Benyumiza Deo , Apio Juliet , Nekesa Catherine , Misuk Ivan , Kumakech Edward 
Published: January 2023

Abstract
Background:
The youth in Uganda, as in much of sub-Saharan Africa, face numerous sexual and reproductive health (SRH) challenges, from HIV infection, unsafe abortions to unwanted pregnancy. This study therefore assessed the utilization of sexual and reproductive health services and associated factors among the youth in Lira City West, Northern Uganda.
Methods:
This was a cross sectional study conducted among 403 young people (15–24 years) in Lira City West division, Lira City. Multi stage cluster sampling technique was used. Data was collected using an interviewer administered questionnaire. Data was analyzed using SPSS version 23.
Results:
Out of 422 youth, 386 participated obtaining a response rate of 91.5%. Less than half, (42.0%)of the youth in Lira City West had utilized SRH services. Family planning, VCT and general counseling services were the most utilized SRH services in the past 12 months. Predictors for the utilization of SRH services were, awareness on SRH (AOR (95% C.I): 0.24(0.08,0.74), being aware of a reproductive health facility (AOR (95% C.I): 4.24(1.62,11.09), discussion of SRH issues with peers/friends (AOR (95% C.I): 3.98(1.53,10.33), having a sexual partner (AOR (95% C.I): 10.00(4.05,24.69), having sexual intercourse (AOR (95% C.I): 4.59(2.18,9.69), access to SRH services (AOR (95% C.I): 2.68(1.12,6.40).
Conclusion:
Utilization of SRH services among the youth was low. Therefore, there is need to develop and strengthen sustainable multisector approaches aimed at increasing awareness as well as linking the young people to youth sexual and reproductive health services.
An example for the non-stability of multi-additive-quadratic-cubic mappings
Authors: Bodaghi Abasalt 
Published: January 2023

Abstract
In this paper, we improve Corollary 1 of [A. Bodaghi and Th. M.Rassias, Functional inequalities for multi-additive-quadratic-cubicmappings, Approximation and Computation in Science and Engineering, Series Springer Optimization and Its Applications (SOIA). Vol. 180, Springer 2022, 103-126.] and then present an example to show that the assertion in the mentioned corollary can not be valid in the singularity case.
2010 Mathematics Subject Classification. 39B52, 39B72, 39B82.
LncRNA ANRIL promotes glucose metabolism and proliferation of colon cancer in a high-glucose environment and associated with worse outcome in diabetic colon cancer patients
Authors: Mosaad Hala , Shalaby Sally , Mahmoud Nevertyty M , Ahmed Mona M , Fayed Alaa , Ashour Hassan R 
Published: January 2023

Abstract

Background:The potential involvement of type 2 diabetes mellitus (T2DM) as a risk factor for colon cancer (CC) has been previously reported. Epigenetic changes, such as deregulation of long non-coding RNA (lncRNA) and microRNA (miR), have been linked to the advancement of CC; however, the effects of high glucose levels on their deregulation and, as a result, colon cancer, have yet to be investigated.
Methods: The study comprised 110 colon cancer patients who were separated into two groups: 50 patients with colon cancer and T2DM, and 60 patients with colon cancer but no diabetic mellitus. QRT-PCR was used to examine the expression of lncRNA ANRIL and miR-186-5p in tissue samples. ANRIL, miR-186-5p, and their downstream target genes HIF-1, PFK, HK, Bcl-2, and Bax were also measured in CC cell lines under various glucose conditions. In CC cell lines, glucose uptake, lactate generation, and cell proliferation were measured.
Results: A significant upregulation of ANRIL expression levels (p<0.001) and a significant downregulation of miR-186-5p expression (p<0.001) in diabetic colon cancer specimens compared to those in non-diabetic colon cancer group were shown. MiR-186-5p expression levels were inversely correlated with ANRILexpression levels, blood glucose levels and HbA1c%. Concerning in vitro model, a significant upregulation of ANRIL, downregulation of miR-186-5p, upregulation of HIF-1α, glycolytic enzymes and activation of antiapoptotic pathway was detected in higher glucose concentrations than lower one. There was a significant increase of glucose uptake, lactate accumulation and proliferation of the Caco2 and SW620 cell lines in a dose dependent manner of glucose concentrations. Moreover, a significant positive correlation between glucose uptake and ANRIL expression was shown.
Conclusions: A high-glucose environment can increase the tumor-promoting effect of ANRIL. ANRIL can promote glucose metabolism and colon cancer proliferation by downregulating miR 186-5p with subsequent upregulation of glycolysis enzymes expression and inhibition of apoptosis.
Oral Pulmonary Arterial Hypertension-Targeted Therapy in Patients with Pulmonary Hypertension due to Interstitial Lung Disease
Authors: Selvan Kavitha C , Teerapuncharoen Krittika , Funk Mary , Rich Stuart , Bag Remzi 
Published: January 2023

Abstract
Purpose
Determine whether treatment with oral PAH-targeted therapy is associated with functional or hemodynamic improvement in patients with PH-ILD.
Methods
We conducted a retrospective review of 1507 consented patients with PH from the University of Chicago PH Registry. Exclusion criteria included: use of inhaled treprostinil, use of PAH-targeted therapy prior to registry enrollment, and enrollment in PH-related clinical trials. Data analyzed included demographics, ILD classification, PAH-targeted therapy, functional data, hemodynamics, and NT-proBNP before and after initiation of treatment. Data were analyzed using paired t-test, or related-samples Wilcoxon signed rank test.
Results
Of 37 patientsincluded, 27 (73%) received treatment with one PAH-targeted therapy and 9 (24%) received dual therapy. At baseline, median NT-proBNP was 1,498 ng/dL [675-3,208], mean pulmonary artery pressure (mPAP) was 45 ± 11 mmHg, and pulmonary vascular resistance (PVR) of 9±4 Wood units. In patients with measurements both before and after treatment with PAH-targetedtherapy, there was a decrease in PVR (n=13, 8 vs 5 WU, p<0.001), an increase in cardiac output (n=13, 4 vs 5 L/min, p=0.014), and a decrease in NT-proBNP levels (n=26, 1,421 vs 842 ng/dL, p=0.045).
Conclusions
In this study, use of PAH-targeted therapy in patients with PH-ILD was associated with statistically significant and clinically meaningful improvements in NT-proBNP and pulmonary hemodynamics.
Novel Resource Allocation Technique for DVB-RCS Compliant Satellite Terminals
Authors: Roy Abhishek Kumar , Kumar Satyendra , Dhaka Manoj K. 
Published: January 2023

Abstract
Satellite communication is advantageous for several reasons such as broad coverage, small installation time of remote user sites, and network services in inhospitable terrains, where installing terrestrial infrastructure is costly. With the advent of broadband multimedia satellites such as Ku and Ka band satellites, multimedia services to the satellite terminals are gaining momentum. Digital Video Broadcast Return Channel via Satellite (DVB-RCS) is an open standard developed by ETSI which has further standardized, commercialized and solved the problem of inter-operability of Ku Band satellite terminals. Satellite bandwidth is scarce therefore treated as precious resource. In the present paper, authors aim to develop and realize the resource allocation techniques in return link channel for DVB-RCS compliant satellite terminals. The paper provides method for giving preference to real time application in terms of early processing of allocation request generated against the real time traffic to reduce delay and also provides method to avoid parallel connection arises due to transmission of terminal on more than one frequency at a time. Authors have realised DVB-RCS resource allocation technique and have given simulation results.
Dynamic Load Predicted Failure Resource Allocation In Virtual Machines Using Hybrid cloud
Authors: Sudhakar P. , ANBARASU P. , Singh Pooja , Shankar Achyut , Maple Carsten 
Published: January 2023

Abstract

Hybrid cloud service is a novel phenomenon that is strategized to estimate the failures in network and configure the Virtual Machines (VMs) in a cost-effective and timely manner. Amazon hybrid cloud offers Infrastructure as a Service (IaaS) in which the infrastructure such as servers, storage network, VMs etc can be dynamically accessed by global users either through manual methods or through automated web-based monitoring and management applications or else through console. Hybrid cloud computing model has been developed with an aim to handle big data since the existing algorithms find it challenging to compute the tasks. The novel hybrid cloud computing model is a result of need for an efficient computational asset that can handle huge scale sequencing experiments. In general, failure is an unavoidable phenomenon in large-scale computing systems. However, when hybrid cloud computing servers continuously fail in executing the tasks, it becomes complicated to handle fault tolerance, availability and reliability. This scenario demands the development of a novel approach that can compensate data loss and ensure automated recovery of the lost data. Further, it should also ensure the non-occurrence of such instances in future. The approach proposed, must enhance the availability of the system and performance of the overall network using VMs. This fault tolerance mechanism was tested under different scenarios involving data, application, selection and matching with faults, as per the requirements of the user. The failure detection model should have the capability to reconfigure the VMs in case of a failure. In this study that dealt with hybrid cloud infrastructure, host hypervisor was used to compare and contrast the failed clusters. The proposed prediction-recovery algorithm was able to identify superior components to achieve file delivery. Further, the AWS failure detection method used an estimation algorithm to achieve dynamic allocation of VMs. The occurrence of failure was hypothesized on the basis of failure dynamics. Further, failure prediction outcomes of the proposed model were also investigated.
Astragalus polysaccharide reduces the incidence of postoperative urethral fistula in the rabbit model of hypospadias
Authors: Shu Zhen , Ai Yaya , Liu Xiang , Wang Cao , Yin Jia , Xiao Minchen , Zhao Peng , Liu Bin 
Published: January 2023

Abstract
Background
Hypospadias is a common congenital malformation in pediatric urology. Surgery is the only treatment option for hypospadias, and urinary fistula is the most common complication after hypospadias repair.
Purpose
The purpose of this study was to establish a model of surgical hypospadias in New Zealand rabbits followed by TIP urethroplasty, postoperative administration of Astragalus polysaccharides (APS), and to study the effect and mechanism of APS on the prevention and treatment of urinary fistula after surgery.
Material and Methods
New Zealand male rabbits were randomly divided into 5 groups: Control group, was fed normal feed without surgery; The operation group, TIP was performed after the establishment of a surgical hypospadias model, and normal feed feeding was given after surgery. In the intervention groups, after the establishment of the surgical hypospadias model, TIP was performed, and the low dose of APS (100mg/kg), the medium dose (200mg/kg), and the high dose (300mg/kg) were mixed into feed feeding, and the urinary fistula rate was statistically calculated after 10 consecutive days of feeding.
Results
The incidence of urinary fistula was significantly lower than that in the surgical group after the addition of APS, and with the increase of the intervention dose of APS, the incidence of urinary fistula showed a decreasing trend. After removing penile tissue, HE examination and WB analysis were performed, compared with the control group, the urethral epithelial cells at the incision site of the operation group were loosely arranged, the layers were reduced, and the inflammatory cells were significantly increased. Compared with the operation group, the urethral epithelial cells at the incision site of the APS intervention group were closely arranged, the layers increased, the inflammatory cells were significantly reduced, and the number of new capillaries increased. In addition, compared with the operation group, the expression levels of TNF-a and NF-kb2 proteins in the intervention group were significantly reduced, and the levels of TGF-β1 and FGF-1 were significantly increased.
Conclusion
The intervention of APS can reduce local inflammatory response, enhance local fibrosis, and reduce the incidence of urinary fistula after hypospadias.
A Comparative Study of Generative Adversarial Networks for Generating Car Damaged Images
Authors: Kyu Phyu Mar , Woraratpanya Kuntpong 
Published: January 2023

Abstract
The deeper the deep learning (DL) models are, the more computational complexity in need of the vast amount of data training requires to get better performance with accurate results. Generative adversarial networks (GANs) have obtained tremendous attention from many researchers with their impressive generation of synthetic instance data via a few source data by alleviating the problems of data scarcity, insufficient data diversity, and producing only limited plausible alternative data using standard data augmentation techniques conforming to the art of low-data-driven DL training in both scratch models, and pre-trained model in a variety of image classification tasks. That is why to defeat the above-referred problems and a lack of publicly available high-quality car-damaged datasets in car damage analysis, we created a custom data with a framework including three different evaluation assessments to generate a synthesized car-damaged dataset as the comparative study of Cycle-Consistent Adversarial Networks (CycleGAN), and Attention-Guided Generative Adversarial Network (AttentionGAN) by transforming one domain to another with our custom car damaged-undamaged dataset. In addition to this, we evaluated our generated car-damaged images based on three different evaluation assessments: firstly using three quantitative GANs metrics such as Inception Score (IS), Fréchet Inception Distance (FID), and Kernel Inception Distance (KID); secondly creating a convolutional neural networks (CNNs) classifier to identify them into real or fake; and finally building a vision-transformer (ViT) classifier to analyze them into damaged or undamaged. After accomplishing our comparative analysis, we can prove that AttentionGAN is better performance than CycleGAN according to all our experimental results.
Association of FOXO3A with Right Ventricular Myocardial Fibrosis and its Speckle-tracking Echocardiographic Detecting in Pulmonary Hypertension： An animal study
Authors: Song Rui , Wang Ping , Yang Lianji , Liu Juan , Chen Zhuo , Ding Yunchuan 
Published: January 2023

Abstract
Background
Myocardial fibrosis may lead to right ventricular (RV) dysfunction, which is a key determinant to poor clinical prognosis and high mortality in patients with pulmonary hypertension (PH). Reduced right ventricular myocardial strain rate was reported in PH patients. The expression of FOXO3A may have an essential role in myocardial fibrosis. However, the relationship between myocardial fibrosis and speckle-tracking echocardiography (STE) or transcription factor FOXO3A is unclear. Therefore, we aimed to exploring the relationship between the molecular mechanism of myocardial fibrosis and the noninvasive ultrasound evaluation index in order to provide a reliable molecular basis for the early diagnosis of right heart dysfunction in clinic.
Methods
Progressive right heart failure (RHF) rat model was established by subcutaneous injection of monocrotaline. Rats divided into baseline, 2-week, 4-week and 6-week according to the course of disease. Right ventricular structure, function and myocardial strain were determined via echocardiography. The degree of myocardial fibrosis was determined by PSR staining. The correlation of myocardial strain to RV myocardial fibrosis was analyzed. The expression of FOXO3A, collagen I, collagen III and BNP were test via western blotting.
Results
As the disease progresses, the right ventricle significantly expands, RV fractional area change (FAC), RV global longitudinal strain (RVLS global) and RV free wall longitudinal strain (RVLS FW) gradually decreases. While the reduction of RVLS global, RVLS FW appeared earlier than that of RVFAC. Significant correlations were observed between RVLS global, RVLS FW and collagen deposition. FOXO3A expression gradually decreased with the disease progression, while the expression of BNP, collagen I, collagen III gradually increased.
Conclusions
Decreased of RVLS global, RVLS FW in RHF rats are happened earlier than RVFAC, and have associated with RV myocardial fibrosis. While, FOXO3A may plays a protective role in the process of RV myocardial fibrosis.
Computed tomography defined femoral artery plaque composition predicts vascular complications during transcatheter aortic valve implantation
Authors: Carande Elliott J , Salim Tarik S , Chase Alexander , Sekar Basker , Aldalati Omar , Hailan Ahmed , Khurana Ayush , Smith Dave , Obaid Daniel R 
Published: January 2023

Abstract
Purpose
Vascular and bleeding complications after transcatheter aortic valve implantation (TAVI) are common and lead to increased morbidity and mortality. Analysis of plaque at the arterial access site may improve prediction of complications.
Methods
We investigated the association between demographic and procedural risk factors for Valve Academic Research Consortium (VARC) vascular complications, as well as a novel method of quantifying plaque composition of the common femoral artery using computed tomography angiography plaque maps created with patient specific x-ray attenuation cut-offs. The relationship between time to haemostasis after TAVI with demographic and procedural risk factors was also investigated.
Results
Twenty-three vascular complications occurred in the 299 patients in the study group (7.7%). There were no demographic risk factors associated with vascular complications and no statistical difference between use of closure device (ProGlide® vs MANTA®) and vascular complications. Vascular complications after TAVI were significantly associated with sheath size (OR 1.36, 95% CI 1.08–1.76, P 0.01) and strongly associated with necrotic core volume in the common femoral artery of the procedural side (OR 17.49, 95% CI 1.21–226.60, P 0.03). The use of the ProGlide® closure device (T 2.99, P 0.004) rather than MANTA® was significantly associated with an increased time to haemostasis after TAVI.
Conclusion
Plaque map analysis of plaque composition of the common femoral artery by CT angiography reveals patients with greater necrotic core are at increased risk of VARC vascular complications.
Problem of Electron-Nuclear Scattering as Inverse Task of Coulomb Interaction
Authors: Ivantsov Mikhail 
Published: January 2023

Abstract
The known quantum-mechanical task of hydrogen-like atom may have a non-probabilistic interpretation as a task of the electrostatics type. In that case, it is possible approach to the electron-nuclear scattering at the necessary solution of fine structure constant. In particular, the Lamb shift opposite the quantum electrodynamics is considered here. From this representation of nuclear structure, the subatomic particles, such as the Higgs boson, beyond the Standard Model can be predict. Perhaps these findings will be relevant in the topic of cosmology.
Dynamic neural stages of proportional gesture-speech integration characterized by cross-modal fragment priming
Authors: Zhao Wanying , Liu Jieyi , Jiang Xintong , Zhou Xiaoqian , Du Yi 
Published: January 2023

Abstract
Background
In natural communications, messages can be expressed through multimodalities and processed predictively. As extra-linguistic information, gesture has frequently been observed to accompany language. Question arises as how the spatial-motoric gesture from auditory interact with the visually linear-analytic speech. Adopting a cross-modal fragment priming paradigm, two experiments were conducted to investigate cortical involvement of gesture-speech integration as lexical representation of speech is proportionally activated and primed by gesture. Proportional presentation of gesture and speech were realized by segmenting gesture and speech fragments into five lengths relative to the gesture discrimination point (DP) and speech identification point (IP), i.e., 0.5, 0.75, 1, 1.25, and 1.5 DP/IP. Experiment 1 quantitively depicted the informativeness of the five lengths of gesture and speech fragments with nameability. Experiment 2 aimed to track the neural processes with event-related potentials (ERPs) when three of the five levels of fragments were chosen and named before, at and after gesture_DP/speech_IP.
Results
Experiment 1 (N = 60) revealed proportional lexical activation relative to the processing time, given the positive correlations between gesture/speech lengths and nameabilities. In Experiment 2 (N = 35), three ERP components were detected to be influenced by distinct gesture-speech information processing stages: an N1 component (0–100 ms of speech onset) modulated solely by gestures; the N400 effect (300-500 ms) found in before_DP/before_IP, DP/IP, after_DP/IP and after_DP/after_IP conditions and inversely correlated to the amount of presented information; followed immediately by the late positive component (LPC) (500-800 ms).
Conclusion
Our results suggest proportionally activated representation of gesture and speech that is inherently distributionally graded. Furthermore, our results uncovered dynamic neural stages when the lexical representations are progressively activated during gesture-speech integration. Thus, this study provides new insights into multimodal semantic processing.