bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of oxidative stress and advanced glycation end‐product formation in purified BSA/glucose glycation system by polyphenol extracts of selected nuts from Pakistan
Authors: Atta Asia , Shahid Muhammad , Kanwal Zunaira , Jafri Saghir Ahmad , Riaz Muhammad , Xiao Hang , Abbas Mazhar , Egbuna Chukwuebuka , Simal‐Gandara Jesus 
Published: March 2023

AbstractGlycation generates advanced glycation end products (AGE) and its intermediates, thus increasing the risk of developing various ailments including diabetes mellitus. Current study was planned to explore the antioxidant and antiglycation potential of selected nuts viz, Juglans regia (Walnut), Prunus dulcis (Almond), Pistacia vera (Pistachio), and Arachis hypogaea (Peanut), locally available and readily consumed in Faisalabad, Pakistan, for their health‐promoting properties. The prepared methanolic extracts of selected nuts were tested for biological activities including the antioxidant and antiglycation potential. The effect of these extracts against oxidation and AGE formation was evaluated by in vitro method using bovine serum albumin (BSA)‐glucose system. Juglans regia, Pistacia vera, and Arachis hypogaea were found rich in phenolics and flavonoids contents with increased reducing potential and least IC50 due to the DPPH free radical scavenging inhibition. Dose‐ and time‐dependent inhibition of glucose‐induced advanced glycation end‐product (AGE) was exhibited by fruit extracts through in vitro bovine serum albumin (BSA)‐glucose system. Juglans regia and Pistacia vera were predominantly effective in the inhibition of early and intermediary glycation products at different incubation conditions. The study indicated that the extracts of selected nuts possess significant antioxidant capacity and are rich in phenolics and flavonoids, making them useful supplements as an important part of a balanced diet.
Microglia play beneficial roles in multiple experimental seizure models
Authors: Gibbs‐Shelton Synphane , Benderoth Jordan , Gaykema Ronald P. , Straub Justyna , Okojie Kenneth A. , Uweru Joseph O. , Lentferink Dennis H. , Rajbanshi Binita , Cowan Maureen N. , Patel Brij , Campos‐Salazar Anthony Brayan , Perez‐Reyes Edward , Eyo Ukpong B. 
Published: March 2023

AbstractSeizure disorders are common, affecting both the young and the old. Currently available antiseizure drugs are ineffective in a third of patients and have been developed with a focus on known neurocentric mechanisms, raising the need for investigations into alternative and complementary mechanisms that contribute to seizure generation or its containment. Neuroinflammation, broadly defined as the activation of immune cells and molecules in the central nervous system (CNS), has been proposed to facilitate seizure generation, although the specific cells involved in these processes remain inadequately understood. The role of microglia, the primary inflammation‐competent cells of the brain, is debated since previous studies were conducted using approaches that were less specific to microglia or had inherent confounds. Using a selective approach to target microglia without such side effects, we show a broadly beneficial role for microglia in limiting chemoconvulsive, electrical, and hyperthermic seizures and argue for a further understanding of microglial contributions to contain seizures.
Reconstruction techniques of the orbit after Brown class III maxillectomy: A systematic review
Authors: Dugast Sophie , Longis Julie , Anquetil Marine , Piot Benoit , Corre Pierre , Huon Jean‐François , Bertin Hélios 
Published: March 2023

AbstractThis systematic review aimed to evaluate the surgical techniques used for orbital floor reconstruction after Brown class III maxillectomy for cancer. Three databases were searched from January 1990 to January 2022. Of the 614 studies identified, 20 were retained after eligibility assessment. The surgical techniques were classified into four groups: free bone flaps (A), alloplastic implants (B), bone grafts (C), and soft‐tissue reconstructions (D). Ectropion and diplopia concerned 42.6% and 6.6% of the patients, respectively. Soft tissue reconstruction was more likely to cause ectropion (17/27), followed by the reconstruction techniques of group B (34/79), group C (26/70), and group A (1/7). Postoperative enophthalmos was identified in 18 patients (9.6%), mostly in group D (5/35), followed by groups B (8/68), A (3/33), and C (2/52). Free bone flaps and alloplastic implants represent good reconstructive options in terms of postoperative ocular parameters.
Si‐Tethered Bis‐ and Tris‐Malonates for the Regioselective Preparation of Fullerene Multi‐Adducts
Authors: Schillinger Franck , Hahn Uwe , Guerra Sebastiano , Minh Nguyet Trinh Thi , Sigwalt David , Holler Michel , Nierengarten Iwona , Nierengarten Jean‐François 
Published: March 2023

AbstractBis‐ and tris‐malonates constructed around a silicon atom have been prepared by reaction of malonate derivatives bearing an alcohol function with di‐tert‐butylsilyl bis(trifluoromethanesulfonate) andtert‐butyl(trichloro)silane, respectively. These compounds have been used for the regioselective bis‐ and tris‐functionalization of C60underBingelconditions. By changing the nature of the linker between the central Si atom and the reactive malonate groups, the malonate precursors have been optimized to produce specific bis‐ and tris‐adducts with excellent regioselectivity. A complete understanding of the electronic and stereochemical factors governing the regioselectivity has been obtained by combining computational studies with a complete analysis of the by‐products formed during the reactions of the Si‐tethered tris‐malonates with C60. Finally, desilylation reactions of the resulting fullerene bis‐ and tris‐adducts have been carried out to generate the corresponding acyclic fullerene bis‐ and tris‐adducts bearing alcohol functions.
Burden of COVID‐19 disease in Kurdistan province in west of Iran using disability‐adjusted life years
Authors: Alinia Cyrus , Bolbanabad Amjad M. , Moradi Ghobad , Shokri Azad , Ghaderi Ebrahim , Adabi Jalil , Rezaei Satar , Piroozi Bakhtiar 
Published: March 2023

AbstractBackground and AimsDuring the coronavirus disease 2019 (COVID‐19) pandemic, about seven million people were infected with the disease, of which more than 133,000 died. Health policymakers need to know the extent and magnitude of the disease burden to decide on how much to allocate resources for disease control. The results of this investigation could be helpful in this field.MethodsWe used the secondary data released by the Kurdistan University of Medical Sciences between February 2020 to October 2021 to estimate the age‐sex standardized disability‐adjusted life years (DALY) by the sum of the years of life lived with disability (YLD) and the years of life lost (YLL). We also applied the local and specific values of the disease utility in the calculations.ResultsThe total DALY was estimated at 23316.5 and 1385.5 per 100,000 populations The YLD and YLL constituted 1% and 99% of the total DALY, respectively. The DALY per 100,000 populations was highest in the men and people aged more than 65 years, but the prevalence was the highest in people under the age of 40.ConclusionsCompared to the findings of the “burden of disease study 2019,” the burden of COVID‐19 in Iran is ranked first and eighth among communicable and noncommunicable diseases, respectively. Although the disease affects all groups, the elderly suffer the most from it. Given the very high YLL of COVID‐19, the best strategy to reduce the burden of COVID‐19 in subsequent waves should be to focus on preventing infection in the elderly population and reducing mortality.
Type A aortic dissection during delivery
Authors: Berberovic Behija Hukeljic , Granov Nermir , Haxhibeqiri‐Karabdic Ilirijana , Hadzimehmedagic Amel , Berberovic Edina 
Published: March 2023

SynopsisThis brief communication describes a rare case of type A aortic dissection successfully managed with aortic replacement following cesarean section.
Clinical use and implementation of the diagnostic classification of mental health and developmental disorders of infancy and early childhood
Authors: Williams Marian E. , Rediker Ashley M. , Mulrooney Kathleen 
Published: March 2023

AbstractThe Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood (DC: 0–5) was developed to provide a framework for diagnosis of infants and young children, and a training curriculum supports implementation of the manual in clinical practice. This study surveyed 100 mental health clinicians (93% female and 53% Latinx/Hispanic) who had completed training in the DC: 0–5 classification system and worked with infants/young children and their families primarily in urban, public insurance‐funded, community mental health settings in the United States. The survey explored their use of the diagnostic manual in clinical practice as well as supports and barriers to implementation. Survey results indicated a high level of adoption of the manual in clinical practice, although all five axes and the cultural formulation were used less often than the Axis I Clinical Disorders section. Barriers to implementation included systemic issues such as agency and billing requirements necessitating simultaneous use of other diagnostic manuals, lack of supports and expertise within their agency, and difficulty making time to fully utilize the manual. The findings suggest that policy and systems changes may be needed to enable clinicians to fully integrate the DC: 0–5 into their case conceptualizations.
Adolescent and young adult research across the HIV prevention and care continua: an international programme analysis and targeted review
Authors: Calabrese Samantha , Perkins Matt , Lee Sonia , Allison Susannah , Brown Gina , Jean‐Philippe Patrick , Chakhtoura Nahida , Moye Jack , Kapogiannis Bill G. 
Published: March 2023

AbstractIntroductionHuman immunodeficiency virus (HIV) continues to rise in young people among low‐ and middle‐income countries (LMIC). The US National Institutes of Health (NIH) supports the largest public investment in HIV research globally. Despite advancements in the last decade, adolescents and young adults (AYA) remain underrepresented in research to improve HIV prevention and care. We undertook a programme analysis of NIH grants and conducted a targeted review of linked publications on international AYA research across the HIV prevention and care continuum (HPCC) to inform new initiatives to address the needs of AYA in these settings.MethodsNIH‐funded grants from 2012 to 2017, pertaining to AYA in LMIC, and evaluating areas of HIV prevention, care and/or treatment were identified. A systematic review of publications limited to funded grants was performed in two waves: 2012–2017 and 2018–2021. The review included a landscape assessment and an evaluation of NIH‐defined clinical trials, respectively. Data on outcomes across the HPCC were abstracted and analysed.ResultsAmong grant applications, 14% were funded and linked to 103 publications for the analytic database, 76 and 27 from the first and second waves, respectively. Fifteen (15%) wave 1 and 27 (26%) wave 2 publications included an NIH‐defined clinical trial. Among these, 36 (86%) did not target a key population (men who have sex with men, drug users and sex workers) and 37 (88%) were exclusively focused on sub‐Saharan Africa. Thirty (71%) publications addressed at least one HPCC milestone. Specific focus was on milestones in HIV prevention, care or both, for 12 (29%), 13 (31%) and five (12%) of publications, respectively. However, few addressed access to and retention in HIV care (4 [14%]) and none included microbicides or treatment as prevention. More focus is needed in crucial early steps of the HIV care continuum and on biomedical HIV prevention interventions.Discussion and ConclusionsResearch gaps remain in this portfolio across the AYA HPCC. To address these, NIH launched an initiative entitled Prevention and Treatment through a Comprehensive Care Continuum for HIV‐affected Adolescents in Resource Constrained Settings (PATC3H) to generate needed scientific innovation for effective public health interventions for AYA affected by HIV in LMIC.
The impact of human papilloma virus on human reproductive health and the effect on male infertility: An updated review
Authors: Das Soumik , Doss C George Priya , Fletcher John , Kannangai Rajesh , Abraham Priya , Ramanathan Gnanasambandan 
Published: March 2023

AbstractIt is believed that human papilloma virus infection (HPV), which is caused by the DNA virus, is the most prominent factor contributing to sexually transmitted disease (STD) in the world, with males having a prevalence rate of 3.5%–45% while that women are 2%–44%. Infertility is a rising problem on a global basis, affecting anywhere from 10% to 30% of couples who have reached reproductive age. This study aims to investigate the existing research on HPV, its connection to male infertility, and how it could be a helpful tool for medical professionals managing HPV in the context of reproductive health care. Infection with HPV has been identified as a risk factor for several spontaneous abortions; however, there is a lack of evidence on how HPV influences individuals undergoing assisted reproductive technology (ART) in terms of live births. The significance of the immune response to HPV‐infected male reproductive system cells and its effect on embryos, as well as the oxidative stress generated by high‐risk HPV DNA damage and genomic instability, is discussed in this review. Further, the association between male individuals infected with HPV and asthenozoospermia should provide a compelling case for vaccinating young people against HPV.
Mpox in the New York metropolitan area, Summer 2022
Authors: Gnanaprakasam Rachel , Keller Marina , Glassman Rebecca , El‐Khoury Marc Y. , Chen Donald S. , Feola Nicholas , Feldman Jared , Chaturvedi Vishnu 
Published: March 2023

AbstractEarly in the 2022 Mpox (MPX) global outbreak, caseloads in the New York Metropolitan area climbed rapidly before other US urban areas. This case series summarizes the authors' clinical experience detecting and treating MPX, during a quickly evolving outbreak. Clinical outcomes were recorded with a focus on varied clinical presentation and outcomes such as complications and response to experimental tecovirimat therapy. A focal or multifocal rash was the most common presenting symptom in 91% of patients. Almost two‐thirds (62%) of patients had anogenital involvement. Proctitis was one of the most painful presentations with 75% requiring antiviral treatment and three patients needing hospitalization for pain management. Most patients responded promptly to antiviral treatment with tecovirimat. Five out of 10 patients treated with tecovirimat reported symptom resolution within 48–72 h of therapy and another three saw resolution within first 96 h. Two patients had poor response to tecovirimat. This series includes the only reported case of an HIV positive, immunocompetent patient who experienced recurrent anal ulcers due to Mpox and required a second course of tecovirimat. Other unique presentations included urethritis, abscess formation and MPX infection postvaccination. Control of this current Mpox outbreak was possible due to timely diagnosis and the availability of both a licensed vaccine and an investigational drug.
Performance assessment and validation of a plaque reduction neutralization test (PRNT) in support to yellow fever diagnostic and vaccine clinical trials
Authors: Dia Moussa , Bob Ndeye Sakha , Talla Cheikh , Dupressoir Anne , Escadafal Camille , Thiam Mareme Seye , Diallo Amadou , Ndiaye Oumar , Heraud Jean Michel , Faye Oumar , Sall Amadou Alpha , Faye Ousmane , Fall Gamou 
Published: March 2023

AbstractYellow fever (YF) virus is a mosquito‐borne virus belonging to the Flaviviridae family that circulates in tropical and subtropical areas of Africa and South America. Despite the availability of an effective vaccine, YF remains a threat to travelers, residents of endemic areas, and unvaccinated populations. YF vaccination and natural infection both induce the production of neutralizing antibodies. Serological diagnostic methods detecting YF virus‐specific antibodies demonstrate high levels of cross‐reactivities with other flaviviruses. To date, the plaque reduction neutralization test (PRNT) is the most specific serological test for the differentiation of flavivirus infections and is considered the reference method for detecting YF neutralizing antibodies and assessing the protective immune response following vaccination. In this study, we developed and validated a YF PRNT. We optimized different parameters including cell concentration and virus‐serum neutralization time period and then assessed the intra‐ and inter‐assay precisions, dilutability, specificity, and lower limit of quantification (LLOQ) using international standard YF serum, sera from vaccinees and human specimens collected through YF surveillance. The YF PRNT has shown good robustness and 100% of intra‐assay precision, 95.6% of inter‐assay precision, 100% of specificity, 100% of LLOQ, and 95.3% of dilutability. The test is, therefore, suitable for use in the YF diagnostic as well as evaluation of the YF vaccine neutralizing antibody response and risk assessment studies.
Financial literacy in individuals trained in economics, management, finance, and accounting
Authors: Tavares Fernando , Santos Eulália , Tavares Vasco 
Published: March 2023

AbstractThis study aims to analyse and compare the perception and the knowledge of financial literacy of the Portuguese with training in Economics, Management, Finance, and/or Accounting. It is used a quantitative methodology based on a questionnaire that studies the perception of financial literacy and assesses financial literacy knowledge. The sample is formed by 395 Portuguese individuals with training in Economics, Management, Finance, and/or Accounting. The obtained results show that the scale of financial literacy perception presents a structure with three factors: 1–2 year financial goals and planning, long‐term saving, and taste for numerical calculations. The results also show that the Portuguese individuals present greater levels of financial literacy perception compared to their actual knowledge of financial literacy. The originality of this study shows that the utilized instrument was adequate to measure the financial literacy perception of the Portuguese individuals with training in the areas of Economics, Management, Finance, and Accounting. The difference between the perception and the actual knowledge of financial literacy among people trained in these areas should encourage a revision of the curriculums of these degrees, to shorten that gap.
Severe lichenoid eruption due to concomitant medications following nivolumab administration
Authors: Kakuta Risa , Tanese Keiji , Hirata Kenro , Emoto Katsura , Takeuchi Sakiko , Shiiya Chihiro , Amagai Masayuki , Kubo Akiharu 
Published: March 2023

AbstractRecently, immune checkpoint inhibitors have been administered for several cancers and have shown great efficacy. However, they are associated with various immune‐related adverse events. Here, we report a case with severe lichenoid eruption following nivolumab administration that improved after the withdrawal of concomitant medications and the patient could continue nivolumab therapy. While nivolumab has been reported to cause severe skin reactions, the current case suggests that severe cutaneous manifestations after nivolumab administration could also be caused by the acquisition of immunogenicity of concomitant medications, including the one that was safely administered before nivolumab treatment and discontinuation of them may enable the patient to continue nivolumab therapy.
Self‐Referenced Subcycle Metrology of Quantum Fields
Authors: Gündoğdu Sinan , Virally Stéphane , Scaglia Marco , Seletskiy Denis V. , Moskalenko Andrey S. 
Published: March 2023

AbstractA new time‐domain method for subcycle metrology of quantum electric fields using a combination of a third order nonlinear optical process and homodyne detection with a local oscillator (LO) field is proposed and analyzed. The new method enables isolation of intrinsically weak quantum noise contribution by subtraction of the shot noise of the LO on a pulse‐by‐pulse basis. Together with the centro‐symmetric character of the nonlinearity, this method unlocks novel opportunities toward terahertz and mid‐infrared quantum field metrologies.
LITTLE INNOVATIONS THAT MAKE A BIG IMPACT
Authors: Murray Jill , Barone Pricci Erica , Decker Stephanie 
Published: March 2023

AbstractThe authors, including Murray, the President of Lackawanna College in Scranton, Pennsylvania; write about innovation initiatives at the school, and their relevance to other organizations. They focus on what they call “Little Innovations,” described in their words as innovation born from necessity as an organization considers how to solve a central, pressing problem. They delineate five steps to little innovations, which in their words are: (1) Wild Questions: Why Can’t We? (2) Practical Questions: How Can We? (3) Build a Team of Great Thinkers (4) Successful Failures (5) Follow Through. Step one has sub‐questions, such as “What if we re‐imagine the basic assumptions of our business?” In step two, “Think about how to break a big idea into its component parts and try it, taking care to create a timeline and assessment plan to figure out if the initiative is worth continuing or taking to a larger scale.” In step three, “Without a culture of trust and a genuine belief in each other’s brain power, free‐flowing conversations can’t happen.” In step four, “Share your failures and how they helped you pivot to the winning idea.” And in step five, “An idea itself isn’t an innovation until a leader or team can make it come to life and create tangible outcomes.”
Microfoundations of innovation: A dynamic CEO capabilities perspective
Authors: Heubeck Tim , Meckl Reinhard 
Published: March 2023

AbstractAlthough sustainable competitive advantages in today's hypercompetitive economy call for strong management skills, the literature lacks a holistic understanding of the specific capabilities chief executive officers (CEOs) utilize to drive innovation. This article derives the dynamic CEO capabilities (DCCs) concept to examine whether CEOs' individual‐level DCCs facilitate firm‐level innovation and proposes that CEO power moderates this relationship. Results from a longitudinal sample of S&P 900 manufacturing firms confirm that strong DCCs drive innovation. Further, powerful CEOs can exert a more significant influence on firms' innovativeness through their DCCs, yet this effect is contingent on the type of CEO power.