Blood Culture Use in Medical and Surgical Intensive Care Units and Wards
Authors: Fabre Valeria , Hsu Yea-Jen , Carroll Karen C. , Salinas Alejandra B. , Gadala Avinash , Bower Chris , Boyd Sarah , Degnan Kathleen O. , Dhaubhadel Pragya , Diekema Daniel J. , Drees Marci , Feeser Baevin , Fisher Mark A. , Flynn Cynthia , Ford Bradley , Gettler Erin B. , Glaser Laurel J. , Howard-Anderson Jessica , Johnson J. Kristie , Kim Justin J. , Martinez Marvin , Mathers Amy J. , Mermel Leonard A. , Moehring Rebekah W. , Nelson George E. , O’Horo John C. , Pepe Dana E. , Robinson Evan D. , Rodríguez-Nava Guillermo , Ryder Jonathan H. , Salinas Jorge L. , Schrank Gregory M. , Shah Aditya , Shelly Mark , Spivak Emily S. , Stewart Kathleen O. , Talbot Thomas R. , Van Schooneveld Trevor C. , Wasylyshyn Anastasia , Cosgrove Sara E. ,   Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program
Published: January 2025

ImportanceBlood culture (BC) use benchmarks in US hospitals have not been defined.ObjectiveTo characterize BC use in adult intensive care units (ICUs) and wards in US hospitals.Design, Setting, and ParticipantsA retrospective cross-sectional study of BC use in adult medical ICUs, medical-surgical ICUs, medical wards, and medical-surgical wards from acute care hospitals from the 4 US geographic regions was conducted. Critical access hospitals, less than 6 months of BC data, and non-US hospitals were excluded. The study included BC use data from September 1, 2019, to August 31, 2021. Data were analyzed from February 23 to July 14, 2024.Main Outcomes and MeasuresThe primary outcome was BC use per 1000 patient-days. Adjusted means with 95% CIs were calculated using mixed-effects negative binomial regression models adjusted for unit type, hospital bed size, geographic region, seasonality, and state COVID-19 case load, with random intercepts accounting for clustering at unit and hospital levels. Secondary outcomes included blood culture positivity, single BCs, BC contamination, and minimum threshold for BC use where blood culture positivity would be optimized.ResultsA total of 362 327 blood cultures were analyzed from 27 medical ICUs, 35 medical-surgical ICUs, 121 medical wards, and 109 medical-surgical wards from 48 hospitals in 19 states and the District of Columbia. The adjusted mean BC use per 1000 patient-days was 273.1 (95% CI, 270.2-275.9) for medical ICUs, 146.0 (95% CI, 144.5-147.5) for medical-surgical ICUs, 80.3 (95% CI, 79.8-80.7) for medical wards, and 65.1 for medical-surgical wards. Blood culture use was significantly higher across all 4 unit types in hospitals with more than 500 beds compared with 500 or less beds and in the West-Midwest compared with other regions. Single blood culture and positive blood culture rates were below 10% across all 4 unit types. Of the 292 units, 97% had a mean BC contamination rate within 3% of the recommended threshold, and 51% were within 1%. The minimum BC use thresholds (ie, BC use below this number may represent undertesting) were 120 BCs per 1000 patient-days for medical ICUs, 80 BCs per 1000 patient-days for medical-surgical ICUs, and 30 BCs per 1000 patient-days for medical-surgical wards.Conclusions and RelevanceThe findings of this study suggest that blood culture positivity may help determine appropriate BC use for individual unit types.