bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti‐tumour properties
Authors: Alessio Nicola , Acar Mustafa Burak , Squillaro Tiziana , Aprile Domenico , Ayaz‐Güner Şerife , Di Bernardo Giovanni , Peluso Gianfranco , Özcan Servet , Galderisi Umberto 
Published: March 2023

AbstractGenotoxic injuries converge on senescence‐executive program that promotes production of a senescence‐specific secretome (SASP). The study of SASP is particularly intriguing, since through it a senescence process, triggered in a few cells, can spread to many other cells and produce either beneficial or negative consequences for health. We analysed the SASP of quiescent mesenchymal stromal cells (MSCs) following stress induced premature senescence (SIPS) by ionizing radiation exposure. We performed a proteome analysis of SASP content obtained from early and late senescent cells. The bioinformatics studies evidenced that early and late SASPs, besides some common ontologies and signalling pathways, contain specific factors. In spite of these differences, we evidenced that SASPs can block in vitro proliferation of cancer cells and promote senescence/apoptosis. It is possible to imagine that SASP always contains core components that have an anti‐tumour activity, the progression from early to late senescence enriches the SASP of factors that may promote SASP tumorigenic activity only by interacting and instructing cells of the immune system. Our results on Caco‐2 cancer cells incubated with late SASP in presence of peripheral white blood cells strongly support this hypothesis. We evidenced that quiescent MSCs following SIPS produced SASP that, while progressively changed its composition, preserved the capacity to block cancer growth by inducing senescence and/or apoptosis only in an autonomous manner.
Facing the Future: The Legacies of Post‐Neoliberalism in Latin America
Authors: Grugel Jean , Riggirozzi Pia 
Published: March 2023

ABSTRACTThis virtual issue reviews the post‐neoliberalism literature published in Development and Change between 2012 and 2018. It reflects on recent and ongoing, multiple experiences of resistance to speculative, extractive, inequitable and unsustainable development and the demands for alternatives that emerged in Latin America. The argument is developed through an analysis of the 18 most relevant articles published in this journal, that make a major contribution to three key interrelated debates, namely: the meaning and policies associated with post‐neoliberalism; challenges of citizenship and democracy; and the sustainability agenda. Collectively, the selected articles provide a detailed and much‐needed discussion about the key achievements, limitations and legacies of post‐neoliberalism.
Parenting and White children's prosocial behaviors toward same‐race and other‐race peers: The moderating role of targeted moral emotions
Authors: Xu Jingyi , Spinrad Tracy L. , Xiao Sonya Xinyue , Eisenberg Nancy , Laible Deborah , Berger Rebecca , Carlo Gustavo 
Published: March 2023

AbstractObjectiveWe examined the associations among parenting, children's moral emotions, and children's prosocial behaviors toward Black peers and White peers.BackgroundParenting practices inform children's prosocial behaviors; however, the contextual and individual factors that predict children's differentiated prosocial behaviors have been understudied.MethodParticipants were 190 White children (5.4 to 8.91 years old, 45.8% female) and their primary parents. Parents reported parenting practices. Children's prosocial behaviors were assessed through distribution tasks; children's sympathy and empathic anger were observed in response to films that depicted injustice toward others.ResultsNurturant parenting positively predicted, whereas restrictive parenting negatively predicted, children's prosocial behaviors toward diverse others. Additionally, parenting predicted children's prosocial behaviors toward Black peers only when children expressed low levels of empathic anger toward victimized Black peers.ConclusionsOverall, nurturant parenting is positively related, and restrictive parenting is negatively related, to children's prosocial behaviors toward different targets. Children's target‐specific empathic anger moderated the relation of specific parenting practices to children's prosocial behaviors toward racial outgroup peers.ImplicationsWhite parents should understand the way that restrictive parenting might impede children's generosity toward diverse others and engage in nurturant parenting, especially when children do not naturally feel concerned about distressed outgroup members.
Dyadic coping and sexual well‐being in couples seeking assisted reproductive technology
Authors: El Amiri Sawsane , Rosen Natalie O. , Brassard Audrey , Rossi Meghan A. , Bergeron Sophie , Péloquin Katherine 
Published: March 2023

AbstractObjectiveThis study examined whether perceptions of the partner's dyadic coping (DC) and of how partners cope together (common DC) are associated with sexual well‐being in couples seeking assisted reproductive technology.BackgroundAlthough infertility has been associated with significant sexual concerns, little is known about the relational processes underlying couples' sexual well‐being.MethodA sample of 232 couples with medical infertility completed questionnaires assessing DC and sexual well‐being (infertility‐related sexual concerns, distress, and satisfaction).ResultsIndividuals who perceived that their partner engaged in higher negative DC reported lower sexual well‐being (actor effects). Men who perceived that their partner engaged in higher positive DC reported higher sexual satisfaction, whereas women reported greater infertility‐related sexual concerns (actor effects). Perceptions of higher common DC were associated with higher sexual well‐being for men and women (actor effects). Women whose partners reported perceptions of higher common DC also reported fewer infertility‐related sexual concerns (partner effect). Analyses adjusted for relationship satisfaction.ConclusionThese findings highlight the need for future longitudinal research to gain a better understanding of the associations between dyadic factors and infertile couples' sexual well‐being.ImplicationsThese results suggest that the interpersonal context surrounding infertile couples' sexual well‐being should be routinely discussed and could be facilitated by promoting greater common DC.
Impacts of healthy marriage and relationship education with integrated economic stability services
Authors: Moore Quinn , Wood Robert G. , Wu April Yanyuan 
Published: March 2023

AbstractObjectiveThis study evaluated the effectiveness of Empowering Families, a healthy marriage and relationship education (HMRE) program for low‐income couples with children supplemented with intensive employment and financial education services.BackgroundPrevious research found that programs offering both HMRE and economic stability services improved couples' relationship quality but not their economic outcomes. Those programs did not fully integrate economic stability and relationship education content, and take‐up rates for employment services were low.MethodEight hundred seventy‐nine eligible couples were randomly assigned to either (a) a program group that was offered Empowering Families or (b) a control group that was not offering this program. Key outcomes were measured 1 year after study enrollment through surveys of both members of the couple.ResultsEmpowering Families improved all examined aspects of couples' relationship quality (the effect size of impacts ranges from 0.20 to 0.30); it did not affect relationship status. Empowering Families did not improve employment outcomes, but it did reduce economic hardship (the effect size of the impact is −0.13).ConclusionEmpowering Families achieved its central goal of strengthening couples' relationship quality. The fact that Empowering Families reduced economic hardship points to the potential value of offering financial literacy services in conjunction with relationship education.ImplicationsHMRE programs that offer intensive and integrated economic stability content can improve the outcomes of low‐income couples with children.
Historical geographies of place naming: Colonial practices and beyond
Authors: Williamson Beth 
Published: March 2023

AbstractEuropean colonialism sought to inscribe order and meaning on non‐European landscapes through the process of place naming. Naming or renaming was fundamental to the extension of imperial control over physical and human environments. This article offers a brief overview of the ways critical place name studies has addressed these colonial practices. In particular, the paper examines the power relationships inherent in place naming, asks questions about authority and authenticity in place naming, highlights the importance of sound in the performance of place names, and explores decolonial mapping practices as an opportunity to challenge neocolonial cartographies. I suggest that critical place name studies has been insufficiently attentive to orthography and that addressing the spelling of place names more directly offers important ways to understand how power and authority intersected with authenticity and reproducibility in colonial naming practices. I conclude by identifying the potential benefits to geographers of prioritising decolonial research by collaborating with indigenous peoples and incorporating indigenous practices within research.
Hydrogel bead delivery system encapsulates loaded with phloretin‐loaded nanostructured lipid carrier: microstructure, release and digestive behaviour
Authors: Gu Liyuan , Sun Rui , Wu Bi , Xia Qiang 
Published: March 2023

SummaryThe research assesses the properties of the phloretin‐loaded nanostructured lipid carriers (NLC) hydrogel bead. Scanning electron microscopy (SEM), dynamic light scattering (DLS) and X‐ray diffraction (XRD) were used to investigate the properties of phloretin NLC hydrogel beads. The in vitro release study indicated that the phloretin NLC hydrogel beads continued to release within 24 h. The simulated digestibility studies showed that the phloretin NLC hydrogel beads could improve digestive behaviour by controlling lipid intake. The results showed that hydrogel beads could be used as an appropriate delivery system for the encapsulation of phloretin. Hence, the NLC hydrogel beads are a potential carrier of phloretin for application in healthy food, which can control lipid intake.
Back for business: The link between foreign experience and entrepreneurship in Latvia
Authors: Vārpiņa Zane , Krūmiņa Marija , Fredheim Kata , Paalzow Anders 
Published: March 2023

AbstractResearch shows that return migrants have a higher propensity to set up an entrepreneurial activity or be self‐employed compared to non‐migrants. We take a multidisciplinary approach and empirically study the case of Latvia as a migration donor country to learn how re‐migrants participate in entrepreneurship back at home. We are interested if return migrants can be seen as a vehicle for entrepreneurship development and if it is worth looking at them as agents of business growth and innovation. Not only we measure the fact of being entrepreneurial but also explore sources that contribute to the higher propensity, attitudes to creating own business venture, level of ambitions and population sentiment towards entrepreneurs. Based on a nationally representative adult population survey of 8000 observations, we find that early‐stage entrepreneurial activity, established business ownership as well as intrapreneurship for return migrants exceed that of the non‐migrant population. The self‐perceived capabilities to start business is higher for those who have lived abroad, and fear of failure is lower. Return migrants also have better business networks and higher growth and export ambitions. Latvian return migrant entrepreneurship is not necessity driven but rather motivated by opportunities. Migration experience, length of stay aboard and capital accumulated abroad are found to be significant predictors of probability to become entrepreneur when controlled for socioeconomic and personal factors.
RETRACTED: A systematic review of social support and related factors among burns patients
Authors: Farzan Ramyar , Ghorbani Vajargah Pooyan , Mollaei Amirabbas , Karkhah Samad , Samidoust Pirouz , Takasi Poorya , Falakdami Atefeh , Firooz Mahbobeh , Hosseini Seyed Javad , Parvizi Arman , Haddadi Soudabeh 
Published: March 2023

AbstractBurn injuries, as a major public health problem, can lead to high morbidity and mortality. Burns is considered as one of the most devastating injuries globally and the fourth most common injury after traffic accidents, falls and interpersonal violence. Burn injuries can affect human life, such as physical and mental health, functional skills, and performance. Changes in appearance, social isolation, stress, anxiety, depression, low self‐esteem, unemployment, financial burden and family problems can occur in these patients. These burn complications can be exacerbated without adequate social support. This systematic review evaluated burn patients' social support and related factors. A systematic search was performed on the international electronic databases such as Scopus, PubMed, Web of Science and Persian electronic databases such as Iranmedex, and Scientific Information Database using keywords extracted from Medical Subject Headings such as ‘Burns’, ‘Social support’, ‘Perceived social support’ and ‘Social care’ from the earliest to 30 April 2022. The quality of the included studies in this review was assessed using the appraisal tool for cross‐sectional studies (AXIS tool). A total of 1677 burn patients were included in this review from 12 studies. Mean score of social support in burn patients based on multidimensional scale of perceived social support, Phillips's social support questionnaire, social support questionnaire, social support scale and Norbeck social support questionnaire were 5.04 (SD = 1.59) of 7, 22.06 (SD = 3.05), 78.20 (SD = 15.00) of 95, 82.24 (SD = 13.70) and 4.14 (SD = 0.99), respectively. Factors such as income, educational attainment, burn surface area, reconstructive surgery, quality of life, self‐esteem, socialisation, posttraumatic growth, spirituality, and ego resilience had a significant positive relationship with social support of burns patients. Social support in patients with burn had a significant negative relationship with factors such as psychological distress, having children, life satisfaction, neuroticism and post‐traumatic stress disorder. Overall, patients with burns had moderate levels of social support. Therefore, it is recommended that health policymakers and managers make it easier for burn patients to adapt to burns by providing psychological intervention programs and the social support needed by burn patients.
RETRACTED: A systematic review of caregivers' knowledge and related factors towards pressure ulcer prevention
Authors: Farzan Ramyar , Yarali Mohsen , Mollaei Amirabbas , Ghaderi Aliasghar , Takasi Poorya , Sarafi Milad , Samidoust Pirouz , Mahdiabadi Morteza Zaboli , Firooz Mahbobeh , Hosseini Seyed Javad , Vajargah Pooyan Ghorbani , Karkhah Samad 
Published: March 2023

AbstractThis systematic review aimed to examine the knowledge of caregivers regarding pressure ulcer (PU) prevention. A thorough, methodical search was conducted from the earliest date to February 1, 2023 using keywords extracted from Medical Subject Headings such as “Caregivers”, “Knowledge”, and “Pressure ulcer” in various international electronic databases such as Scopus, PubMed, Web of Science, and Persian electronic databases such as Iranmedex and Scientific Information Database. The quality of the studies included in this systematic review was evaluated using an appraisal tool for cross‐sectional studies (AXIS tool). In total, 927 caregivers participated in the eight studies. The average age of the participants was 40.50 (SD = 12.67). Among the participants, 61.87% were women. The average caregiver's knowledge of PU prevention was 53.70 (SD = 14.09) out of 100, which suggests a moderate level of knowledge. Factors such as level of education, age, occupation, information about PUs, attitude, and practice had a significant positive relationship with caregivers' knowledge related to the prevention of PUs. Knowledge had a significantly negative relationship with age. In addition, marital status, type of relationship, age, gender, occupation, level of education, and inpatient wards had a significant relationship with caregivers' knowledge regarding PUs prevention. Therefore, managers and policymakers in the medical field can help increase caregivers' knowledge by providing an online or in‐person educational platform relevant to PU prevention.
‘Different things at different times’: Wellbeing strategies and processes identified by parents of children who have an intellectual disability or who are autistic, or both
Authors: Griffin Joanna , Gore Nick 
Published: March 2023

AbstractBackgroundMost parents of children with an intellectual disability or who are autistic identify positives in their family life and their own wellbeing, in addition to reported mental health challenges. Several models and interventions have been developed in relation to parent carer wellbeing. Few studies have asked parent carers how they support their own wellbeing.MethodAdopting an interpretive phenomenological approach this study utilised semi‐structured interviews. Seventeen parent carers were asked what supported their emotional wellbeing. Template Analysis was applied to develop themes.ResultsAll participants identified factors that supported their wellbeing. Themes included strategies that countered stress (time for themselves, relaxation, ‘parking’ difficulties) and broader wellbeing strategies (finding meaningful life direction, greater understanding of child). An ongoing process of supporting wellbeing by ‘Reorienting and Finding Balance’ appeared central.ConclusionsSelf‐identified, multi‐dimensional strategies benefit parents' emotional wellbeing and should be considered in the context of support provided to families.
NR3C2 inhibits the proliferation of colorectal cancer via regulating glucose metabolism and phosphorylating AMPK
Authors: Liu Hui , Lei Wenqi , Li Zhigui , Wang Xiaodong , Zhou Liming 
Published: March 2023

AbstractWe aim to investigate the roles and mechanisms of NR3C2 in colorectal cancer (CRC). The expression of NR3C2 in CRC tumours and paired paracancerous tissues of 71 CRC patients and five CRC cell lines was detected by western blotting, immunohistochemistry and real‐time reverse‐transcription PCR. Moreover, NR3C2 was overexpressed or knocked down in CRC cells by lentiviral vector transfection. The proliferation of cells was measured by MTT, colony formation assay and flow cytometry. Glucose metabolism was assessed by detecting lactate production, glucose consumption and ATP production. Western blotting and real‐time reverse‐transcription PCR were used to detect the expression of AMPK, LDHA and HK2. The expression of NR3C2 was significantly decreased in CRC tumours compared to paracancerous tissues, which was correlated with distant metastasis, poor prognosis and advanced stages of CRC patients. Overexpressing NR3C2 suppressed the proliferation and promoted the G2/M cell cycle arrest of CRC cells. Furthermore, NR3C2 inhibited glucose metabolism by decreasing the expression of HK2 and LDHA. The phosphorylation of AMPK was also downregulated in CRC cells overexpressing NR3C2. This study demonstrated that NR3C2 inhibited the proliferation of CRC by inhibiting glucose metabolism and phosphorylation of AMPK which may serve as a therapeutic target for CRC.
Cross‐sectional quantitative validation of the paediatric Localized Scleroderma Quality of Life Instrument (LoSQI): A disease‐specific patient‐reported outcome measure
Authors: Zigler C. K. , Lin L. , Ardalan K. , Jacobe H. , Lane S. , Li S. C. , Luca N. J. C. , Prajapati V. H. , Schollaert K. , Teske N. , Torok K. 
Published: March 2023

AbstractBackgroundThe Localized Scleroderma Quality of Life Instrument (LoSQI) is a disease‐specific patient‐reported outcome (PRO) measure designed for children and adolescents with localized scleroderma (LS; morphea). This tool was developed using rigorous PRO methods and previously cognitively tested in a sample of paediatric patients with LS.ObjectiveThe purpose of this study was to evaluate the psychometric properties of the LoSQI in a clinical setting.MethodsCross‐sectional data from four specialized clinics in the US and Canada were included in the analysis. Evaluation included reliability of scores, internal structure of the survey, evidence of convergent and divergent validity, and test–retest reliability.ResultsOne hundred and ten patients with LS (age: 8–20 years) completed the LoSQI. Both exploratory and confirmatory factor analysis supported the use of two sub‐scores: Pain and Physical Functioning, and Body Image and Social Support. Correlations with other PRO measures were consistent with pre‐specified hypotheses.LimitationsThis study did not evaluate longitudinal validity or responsiveness of scores.ConclusionResults from a representative sample of children and adolescents with LS continue to support the validity of the LoSQI when used in a clinical setting. Future work to evaluate the responsiveness is ongoing.
Inferno: A guide to field experiments in online display advertising
Authors: Johnson Garrett A. 
Published: March 2023

AbstractOnline display advertising is a hostile medium for field experiments. Display‐ad effects are tiny and necessitate large‐scale experiments. The experimenter has limited control because ad exposure is jointly determined by advertisers, users, algorithms, and market competition. As such, online display ads provide useful lessons for experimenters at the frontier of digital research more generally. Display‐ad experiments place renewed focus on old topics like statistical power and compliance as well as on newer issues like identity fragmentation, experimental spillovers, and incrementality optimization. In this guide, I review these challenges, best practices, and new developments.
Beyond the LTV Ratio: Lending Standards, Regulatory Arbitrage, and Mortgage Default
Authors: GALÁN JORGE E. , LAMAS MATÍAS 
Published: March 2023

AbstractBooming house prices are historically correlated with loose lending standards. Nonetheless, in Spain the loan‐to‐value (LTV) ratio failed to capture imbalances during the last housing boom. Using loan‐level data from millions of mortgages we show that inflated collateral valuations, used by banks as a mechanism to circumvent regulation, distorted the informative value of LTV, and masked the accumulation of risk. We identify that regulation relying upon a single measure is more prone to suffer from regulatory arbitrage, and that the optimal policy mix varies over the financial cycle. Overall, our study provides useful insights for the implementation of borrower‐based measures.