bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term support referrals to enhance food security and well-being in older adults: Texas physicians and nurses on what works
Authors: Chaudhuri Nandita , Alvi Laila Hussain , Williams Ashleigh 
Published: January 2023

Abstract
Aim
Senior participation in the congregate meal programs (CMPs) has alarmingly declined over the past decade in Texas as elsewhere in the nation. The purpose of this survey study was to identify the possible reasons for this decline from the viewpoint of the Texas physicians and nurses who are key in coordinating care and ensuring food security for the vulnerable older Texans by referring them to community-based long-term support services (LTSS).

Subject and methods
The methodology adopted was an online panel survey of physicians and nurses from rural and urban Texas counties. Structured multiple-choice and open-ended questions primarily focused on provider referral processes, reasons for connecting older clients to CMPs, perceptions about various aspects of these programs, possible reasons for the decline in participation, suggestions to make the programs an integral part of the community-based LTSS referral system, and how to address the COVID-19 pandemic constraints on the programs.

Results
As a majority of the healthcare providers surveyed were unaware of the CMPs in their communities, the study spotlighted an urgent need for a better-coordinated referral process centered on strategic marketing and awareness-building about the CMPs, including an extensive healthcare provider education component as well as an overall improvement in meal quality and variety.

Conclusion
The study highlights a need for additional research so decision-makers better understand how to best disseminate information to healthcare providers to improve the referral mechanisms, increase the referrals, and enhance the overall CMP program quality to benefit the vulnerable food-insecure older adults.
Reinforcing or Disrupting Gender Affirmation: The Impact of Cancer on Transgender Embodiment and Identity
Authors: Ussher Jane M. , Power Rosalie , Allison Kimberley , Sperring Samantha , Parton Chloe , Perz Janette , Davies Cristyn , Cook Teddy , Hawkey Alexandra J. , Robinson Kerry H. , Hickey Martha , Anazodo Antoinette , Ellis Colin 
Published: January 2023

AbstractThere is a pressing need for greater understanding and focus on cancer survivorship and informal cancer caring of trans people (binary and non-binary), across tumor types, to inform culturally safe trans inclusive cancer information and care. This qualitative study, part of the mixed methods Out with Cancer project, examined experiences of trans embodiment and identity after cancer diagnosis and treatment. We drew on open-ended survey responses from 63 trans cancer survivors and 23 trans cancer carers, as well as interviews and a photo-elicitation activity with a subset of 22 participants (15 cancer survivors, 7 cancer carers). Reflexive thematic analysis identified three themes: Cancer enhances trans embodiment, through experiences of gender euphoria following cancer treatment, and acceleration of decisions about gender affirmation; cancer erases or inhibits gender affirmation; trans embodiment is invisible or pathologized in cancer care. These findings demonstrate that trans embodiment and identity, as well as the process of gender affirmation, may be disrupted by cancer or informal cancer caring. Conversely, cancer and cancer treatment can positively impact the embodied identity and lives of trans people, despite the anxiety and strain of negotiating medical procedures. However, if healthcare professionals operate within a cis-heteronormative framework and do not understand the meaning of embodied change following cancer treatment for trans individuals, these positive benefits may not be realized.
Exploring uplift modeling with high class imbalance
Authors: Nyberg Otto , Klami Arto 
Published: January 2023

AbstractUplift modeling refers to individual level causal inference. Existing research on the topic ignores one prevalent and important aspect: high class imbalance. For instance in online environments uplift modeling is used to optimally target ads and discounts, but very few users ever end up clicking an ad or buying. One common approach to deal with imbalance in classification is by undersampling the dataset. In this work, we show how undersampling can be extended to uplift modeling. We propose four undersampling methods for uplift modeling. We compare the proposed methods empirically and show when some methods have a tendency to break down. One key observation is that accounting for the imbalance is particularly important for uplift random forests, which explains the poor performance of the model in earlier works. Undersampling is also crucial for class-variable transformation based models.
Three Early Formal Approaches to the Verification of Concurrent Programs
Authors: Jones Cliff B. 
Published: January 2023

AbstractThis paper traces a relatively linear sequence of early research approaches to the formal verification of concurrent programs. It does so forwards and then backwards in time. After briefly outlining the context, the key insights from three distinct approaches from the 1970s are identified (Ashcroft/Manna, Ashcroft (solo) and Owicki). The main technical material in the paper focuses on a specific program taken from the last published of the three pieces of research (Susan Owicki’s): her own verification of her Findpos example is outlined followed by attempts at verifying the same example using the earlier approaches. Reconsidering the prior approaches on the basis of Owicki’s useful example illuminates similarities and differences between the proposals. Along the way, observations about interactions between researchers (and some “blind spots”) are noted.
Factors influencing accumulation of Zn, Cu, and Ca in the tissues of spiny-cheek crayfish (Faxonius limosus, Rafinesque, 1817)
Authors: Stanek Magdalena , Chachaj Bogusław , Różański Szymon Ł. 
Published: January 2023

AbstractBoth physicochemical and biological factors affect the degree of metal accumulation in crayfish tissues. The content of metals and correlations between the metal concentrations in different tissues and the total length of crayfish is suitable indicators of contamination of the aquatic environment. The aim of the study was to analyse the effect of age and sex of crayfish on the degree of accumulation of Ca, Cu, and Zn in the muscle and exoskeleton. A total of 100 individuals of the spiny-cheek crayfish (Faxonius limosus, Rafinesque, 1817) were caught from Głowińsk reservoir (Poland) in October 2019 using fyke nets. Metal concentrations were determined in freeze-dried samples of the abdominal muscle, exoskeleton, bottom sediment, and water using atomic absorption spectroscopy (AAS). Here, we show that the highest concentrations of Zn were found in the muscle of 4-year-old females, Cu in 3-year-old males, and Ca in 4-year-old males. Sex was a significant factor affecting the content of Ca in the muscle and Zn in the exoskeleton. Age was a significant factor affecting the content of Zn, Cu, and Ca in the muscle and Zn and Cu in the exoskeleton. The bioconcentration factor (BCF) of Zn and Cu in the muscle and exoskeleton of spiny-cheek crayfish was much higher from water than from sediments, unlike Ca. Furthermore, we found significant correlation for muscle between Zn and total length in 3-year-old females and 4-year-old males and between Cu and TL in 3-year-old males. Analysing the recommended daily intake (RDI) for the investigated minerals confirmed that the consumption of 100 g of spiny-cheek crayfish muscle could meet daily requirement for Zn up to 27.5%, for Ca in 12.4%, and over 100% for Cu. The conducted analyses confirmed that the consumption of crayfish meat was safe for the health of potential consumers in terms of the analysed metal content.
Automated analysis of finger blood pressure recordings provides insight in determinants of baroreflex sensitivity and heart rate variability—the HELIUS study
Authors: Collard D. , Westerhof B. E. , Karemaker J. M. , Stok W. J. , Postema P. G. , Krediet C. T. P. , Vogt L. , van den Born B. J. H. 
Published: January 2023

AbstractSympathovagal balance is important in the pathogenesis of hypertension and independently associated with mortality. We evaluated the value of automated analysis of cross-correlation baroreflex sensitivity (xBRS) and heart rate variability (HRV) and its relationship with clinical covariates in 13,326 participants from the multi-ethnic HELIUS study. Finger blood pressure (BP) was continuously recorded, from which xBRS, standard deviation of normal-to-normal intervals (SDNN), and squared root of mean squared successive difference between normal-to-normal intervals (RMSDD) were determined. A subset of 3356 recordings > 300 s was used to derive the minimally required duration by comparing shortened to complete recordings, defined as intraclass correlation (ICC) > 0.90. For xBRS and SDNN, 120 s and 180 s were required (ICC 0.93); for RMSDD, 60 s (ICC 0.94) was sufficient. We included 10,252 participants (median age 46 years, 54% women) with a recording > 180 s for the regression. xBRS, SDNN, and RMSDD decreased linearly up to 50 years of age. For xBRS, there was a signification interaction with sex, with for every 10 years a decrease of 4.3 ms/mmHg (95%CI 4.0–4.6) for men and 5.9 ms/mmHg (95%CI 5.6–6.1) for women. Using splines, we observed sex-dependent nonlinearities in the relation with BP, waist-to-hip-ratio, and body mass index. Future studies can help unravel the dynamics of these relations and assess their predictive value.
Graphical Abstract
Panel 1 depicts automatic analysis and filtering of finger BP recordings, panel 2 depicts computation of xBRS from interpolated beat to beat data of systolic BP and interbeat interval, and (IBI) SDNN and RMSDD are computed directly from the filtered IBI dataset. Panel 3 depicts the results of large-scale analysis and relation of xBRS with age, sex, blood pressure and body mass index.
Current Phosphorus and Potassium Fertiliser Application Rates Do Not Limit Tuber Yield and Quality in Potato Production Systems in the Netherlands
Authors: Ravensbergen Arie Pieter Paulus , van Ittersum Martin K. , Kempenaar Corné , Reidsma Pytrik 
Published: January 2023

AbstractCurrent ware potato yields in the Netherlands are approximately 70% of their potential. It is hypothesised by several stakeholders within the potato value chain that part of the potato yield gap is caused by a lack of phosphorus (P) and potassium (K) application. In this study, we analysed for 46 farmers’ fields if increasing P and K fertiliser application rates led to a higher yield and yield quality. We found that, on average, increased P and K fertiliser application did not result in a significantly higher yield for two currently cropped potato cultivars on two different soil types in the Netherlands (Innovator on clay soils and Fontane on sandy soils) and in two years (2019 and 2020). However, on sandy soils at relatively lower farmer K application rates, our K application led to a small positive yield response up to 5 t ha−1. On clay soils, there was an average positive yield response to our K application at lower yield levels of the control. For P, we did not find any correlation between yield response to P application and the amount of P applied by farmers or any of the measured soil parameters. In terms of yield quality, the K application led to a slight reduction in underwater weight on sandy soils in 2019 and a slight increase in the yield of large tubers in 2020. We conclude that, although in some fields there was a small positive yield effect of increased K application, increasing P and K application rates will not narrow the potato yield gap and improve potato yield quality in the Netherlands. Instead, increasing the P and K application will decrease P and K use efficiency and hence is not recommended from an environmental and economic perspective.
Objective assessment of intraoperative skills for robot-assisted partial nephrectomy (RAPN)
Authors: Farinha Rui , Breda Alberto , Porter James , Mottrie Alexandre , Van Cleynenbreugel Ben , Vander Sloten Jozef , Mottaran Angelo , Gallagher Anthony G. 
Published: January 2023

AbstractRAPN training usually takes place in-vivo and methods vary across countries/institutions. No common system exists to objectively assess trainee capacity to perform RAPN at predetermined performance levels prior to in-vivo practice. The identification of objective performance metrics for RAPN training is a crucial starting point to improve training and surgical outcomes. The authors sought to examine the reliability, construct and discriminative validity of objective intraoperative performance metrics which best characterize the optimal and suboptimal performance of a reference approach for training novice RAPN surgeons. Seven Novice and 9 Experienced RAPN surgeons video recorded one or two independently performed RAPN procedures in the human. The videos were anonymized and two experienced urology surgeons were trained to reliably score RAPN performance, using previously developed metrics. The assessors were blinded to the performing surgeon, hospital and surgeon group. They independently scored surgeon RAPN performance. Novice and Experienced group performance scores were compared for procedure steps completed and errors made. Each group was divided at the median for Total Errors score, and subgroup scores (i.e., Novice HiErrs and LoErrs, Experienced HiErrs and LoErrs) were compared. The mean inter-rater reliability (IRR) for scoring was 0.95 (range 0.84–1). Compared with Novices, Experienced RAPN surgeons made 69% fewer procedural Total Errors. This difference was accentuated when the LoErr Expert RAPN surgeon’s performance was compared with the HiErrs Novice RAPN surgeon’s performance with an observed 170% fewer Total Errors. GEARS showed poor reliability (Mean IRR = 0.44; range 0.0–0.8), for scoring RAPN surgical performance. The RAPN procedure metrics reliably distinguish Novice and Experienced surgeon performances. They further differentiated performance levels within a group with similar experiences. Reliable and valid metrics will underpin quality-assured novice RAPN surgical training.
Lnc_000048 Promotes Histone H3K4 Methylation of MAP2K2 to Reduce Plaque Stability by Recruiting KDM1A in Carotid Atherosclerosis
Authors: Zhang Shuai , Sun Yu , Xiao Qi , Niu Mengying , Pan Xudong , Zhu Xiaoyan 
Published: January 2023

Abstract
Stabilizing and inhibiting plaque formation is a key challenge for preventing and treating ischemic stroke. KDM1A-mediated histone modifications, which involved in the development of training immunity, ultimately exacerbate the outcomes of inflammation. Although lncRNAs can recruit KDM1A to participate in histone methylation modification and regulate inflammation, cell proliferation, and other biological processes, little is known about the role of KDM1A-lncRNA interaction during atherosclerosis. The present study sought to delineate the effect of the interaction between lnc_000048 and KDM1A on plaque rupture in carotid atherosclerosis, as well as the potential mechanism. Our results revealed that lnc_000048 reduced the activity of histone demethylase and activated MAP2K2 expression by interacting with KDM1A. Furthermore, upregulated lnc_000048 indirectly regulated ERK phosphorylation by MAP2K2 and eventually activated the inflammatory response through the MAPK pathway, which was involved in atherosclerosis. Importantly, our study using ApoE-/- mice confirmed the regulatory role of lnc_000048 in promoting inflammation and collagen degradation in atherosclerotic plaques. These results suggest that targeting the lnc_000048 /KDM1A/MAP2K2/ERK axis may be a promising strategy for preventing atherosclerosis.
Comparative Study of Different Acupoints for Treating Acute Myocardial Ischemia in Mice
Authors: Hong Hao , Cao Xin , Meng Xiang-Min , Pang Qiu-Yu , Zhu Li-Juan , Yu Shu-Guang , Zhu Bing-Mei 
Published: January 2023

AbstractAcupuncture point specificity has been recognized as a key scientific issue in traditional Chinese medicine (TCM), but there is limited clinical trial or animal study to verify the characteristics of PC6, BL15, and ST36 in the protection from myocardial injury. We aimed to compare the effects among these three acupoints on the acute myocardial infarction mice model and to explore possible mechanisms for the first time. We found that PC6 is the most appropriate acupoint to deliver efficacy and safety to treat acute MI in mice. BL15 stimulation improved the systolic function, but increased the risk of arrhythmia. ST36 only slightly attenuated systolic function and had no effect on arrhythmia during MI. RNA profiles of skin tissue in local acupoints demonstrated that the most altered DEGs and related pathways may partly support its best effects of PC6 treatment on MI injury, and support the observed phenomenon of the acupoint specificity.Graphical abstract
Adsorbents, mobile phases, and strategies for the chromatographic separation of betulinic, oleanolic, and ursolic acids
Authors: Azenha Ivo S. , Simões Mário M. Q. , Mendes Adélio , Silva Carlos M. 
Published: January 2023

AbstractA critical overview of the separation of three relevant triterpenic acids, namely betulinic, oleanolic, and ursolic acids, by liquid and supercritical fluid chromatography is presented in this review. These triterpenic acids are commonly found in different biomass residues and have raised great research attention in recent years due to their broad and valuable therapeutic properties. Accordingly, fundamental aspects such as solubilities in single and mixed solvents, commercial stationary phases (octadecylsilyl and other bonded phases like triacontylsilyl, as well as porous graphitic columns), custom adsorbents (molecularly imprinted polymers and other polymeric adsorbents), mobile phases (conventional HPLC solvents and super/subcritical fluids), mobile-phase modifiers (acidic, basic, and cyclodextrins), pre-column derivatization strategies, and influence of temperature have been compiled, analyzed and thoroughly discussed in terms of (calculated) separation selectivities, peaks resolution, orders of elution, systems descriptors, etc. The most relevant achievements and gaps in this area of research are highlighted, together with a final comparison of the separation performance of the chromatographic systems reported in the literature.
Lack of Faecalibacterium prausnitzii and Bifidobacterium is associated with a higher risk of metabolic associated fatty liver disease in young-onset type 2 diabetes
Authors: Chen Sijie , Cai Shuting , Xu Jing , Chen Binbin , Chen Xiaoli , Xiong Hongping 
Published: January 2023

Abstract

Background
The incidence of comorbidity between type 2 diabetes mellitus (T2DM) and metabolic-associated fatty liver disease (MAFLD) is high, and patients tend to be younger. When people develop metabolic diseases such as T2DM and MAFLD, the original homeostasis of the gut microbiota in the body is disrupted, and gut flora drift occurs. This study investigated the relationship between the number of gut flora and MAFLD in young-onset T2DM.

Methods
This retrospective study analyzed 44 adolescent T2DM patients who were divided into a non-MAFLD group and a MAFLD group. Anthropometric measurements, clinical and biochemical markers, inflammatory markers, thyroid function assessments, and stool specimens were collected. Real-time PCR was performed to quantify several important gut flora constituents at the genus level. Student’s t-test and the chi-square test were applied for group comparisons, and binary regression models were used to explore the relationship between gut flora and MAFLD in young-onset T2DM.

Results
Among the 44 subjects, 26 (59.1%) were diagnosed with MAFLD, and 18 (40.9%) were not. Compared with the non-MAFLD group, body mass index (BMI), abdominal circumference, and levels of blood uric acid and thyroid stimulating hormone (TSH) in the MAFLD group were significantly increased, and age level and high-density lipoprotein cholesterol (HDL-C) were significantly decreased (p < 0.05). Compared with the non-MAFLD group, the abundance of Faecalibacterium prausnitzii and Bifidobacterium in the MAFLD group was significantly reduced, and the abundance of Enterococcus and Lactobacillus was significantly increased (p < 0.05). In the multivariate regression analysis, Faecalibacterium prausnitzii and Bifidobacterium were independent protective factors for MAFLD in young-onset T2DM, after excluding confounding factors.

Conclusion
In young-onset T2DM, there was a difference in gut flora between patients with MAFLD and those without MAFLD. Faecalibacterium prausnitzii and Bifidobacterium were independent protective factors for MAFLD in young-onset T2DM.
Globalized Religious Aftershock at the Beginning of the Twentieth Century—the Apapocúava-Guaraní Cataclysm and the 1906 San Francisco Earthquake
Authors: van der Hoek Stefan 
Published: January 2023

AbstractThe impact of environmental catastrophes and crises on religion and religious discourses in history and modernity has been described frequently and from different perspectives. However, the interpretations and narratives of scriptless civilizations have remained largely unnoticed. Due to the concrete lack of reliable sources of information, those interpretations and narratives can nowadays only be recorded and processed in the scientific discourse in a fragmentary way. Therefore, this article unfolds along the early work of ethnologist and linguist Curt Unckel (1883–1946), who was called Nimuendajú during his lifetime, the thesis that an indigenous group of the Apapocúava-Guaraní tribe in southeastern Brazil correlated the global information dissemination of the 1906 San Francisco earthquake with cosmological narratives of an impending apocalypse, leading to the decline and cultural degeneration of the group. The article thus demonstrates how cosmologies and world perceptions of an indigenous tribe at the dawn of globalization can be reconstructed and how information about catastrophic events from the news was processed with immediate local changes by a scriptless culture on the Brazilian frontier in the early twentieth century. In doing so, this article examines the role of media and communication in globalized modernity and how media literacy influences religious perception.
Local sourcing embeddedness, manufacturing relocation, and firm attitudes toward the US-China trade war: A survey analysis of China-based MNC subsidiaries
Authors: Zeng Ka , Xu Yingjie , Xie Zhenzhen 
Published: January 2023

AbstractThis paper examines the attitudes of multinational corporations (MNCs) toward the U.S.-China trade war through an original survey of China-based MNC subsidiaries in the manufacturing industry. Our argument is in two parts. First, firms that have relocated production outside of China or are considering such moves should be less likely to oppose the trade war as they possess outside options that reduce their vulnerability to trade restrictions. Second, firms’ tendency toward production relocation can in turn be explained by their local sourcing dependence, as measured by the level of such dependence and the degree to which their operations require supplier certification. This is because firms more heavily embedded in local supplier networks face stronger resource dependence that increases organizational inertia, reducing their ability to switch to alternative suppliers and therefore relocating production to other destinations. Our findings corroborate our hypotheses, highlighting how the heterogeneity in MNCs’ supply chain relationships may influence both their manufacturing relocation decisions and trade policy preferences.