bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chia sprouts and microgreens as a new nutraceutical raw materials and their health-promoting impact in modern dietetics
Authors: Szopa Agnieszka , Motyka Sara , Ekeirt Halina 
Published: May 2023

Abstract
Today, plant sprouts are one of the most important forms of functional foods (FOSHU – Food For Specified Health Use), in nutraceutical diets based on so-called “healthy food”. The health-promoting effects of sprouts are due to their rich chemical composition and high nutritional quality compared to standard crop raw materials. Recently, many scientific studies have pointed to the medicinal and therapeutic effects of chia seeds (Salvia hispanica), but there is still a lack of research on the composition and biological properties of chia sprouts. In addition to chia sprouts, chia microgreens (microleaves) are becoming prominent in the food industry. This paper reviews the literature data on research on chia sprouts and microgreens. In the work, the process of sprouting chia seeds to boost their nutraceutical properties by increasing their content of protein, dietary fiber, vitamins and mineral salts, is revealed. The review underlines the fact that sprouting contributes to the enhancement of antioxidant potential by increasing the production of polyphenolic compounds from the phenolic acid group and flavonoids. What is more, single studies noted in the study indicate the antimicrobial properties of chia sprout extracts against Gram-negative (Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacterial strains. The paper is the first comprehensive review of the latest scientific information on the comparison of chia: dry seeds, sprouted seeds, sprouts and microgreens.
Mephedrone – a synthetic derivative of cathinone
Authors: Bielecka-Papierz Gabriela , Poleszak Ewa , Serafko Anna 
Published: May 2023

Abstract
Novel psychoactive substances (NPS) are a very diverse group of recreational drugs that mimic effects of classic drugs of abuse and, at least at the beginning, are not usually prohibited. Representative of this group is mephedrone – a cathinone derivative. It is widely used as a recreational drug, particularly among club guests. Mephedrone`s effects are compared to effects of cocaine and MDMA but are more short-lived and include: psychostimulation, enhanced empathy, reduced feeling of tiredness, euphoria, hallucinations. This drug also exerts adverse effects, such as: anxiety, delusions, paranoia, psychosis, increased body temperature, elevated blood pressure, sleep disturbances. According to surveys performed on mephedrone users, it may be addictive. Those findings confirms a growing number of behavioural and molecular studies on animals. Mephedrone acts mainly via increasing monoamine transmission through increasing release of dopamine, serotonin and noradrenaline into synaptic cleft, inhibiting their re-uptake and reducing their metabolism. However, participation of other transmitters, modulators and pathways are investigated, including glutamate and nitric oxide. Favorable routes of administering mephedrone is intranasal and per os. Moreover, most often drug users use it in a binge way, e.g. taking repeated doses of a drug in a short period of time. According to animal studies, this pattern of mephedrone use leaves more neural injuries than taking it regularly, but in smaller doses. Our aim was to present a short, but essential, overview of the current knowledge on mephedrone, focusing on its effects, mechanism of action, animal studies evaluating its influence on the brain structures, toxicity and pharmacokinetics.
Innovative Tourism Products as Sustainable Solutions for Emerging Economies
Authors: Gabor Manuela Rozalia , Oltean Flavia Dana , Coca Andrei 
Published: May 2023

Abstract
The current trend in tourism is no longer one of relaxation in the two important seasons but of experiential tourism, developing of new types of tourism, each country identifying (but especially reinventing) its own potential and promoting it below the form of innovative tourist packages and/or products and/or services. Innovation as a concept is setting up the scene for economic growth and is an important tool for economic progress and competitiveness. The aim of this research is to make a bibliometric analysis to find out the most important aspects of innovation linked to tourism as sustainable solutions for tourism in emerging economies. As methods for bibliometric analysis the VOSviewer 1.6.18 software was used on the Web of Science papers to find out the research concepts linked to innovation and tourism. Also, we applied Google Trends search for some of the newest types of tourism to find out the interest of tourists over the last two decades (2010 – 2023) for innovative products from tourism industry (such as: babymoon, adventure, medical, dental, hunting, ecotourism, heritage, museum, etc.). The results emphasis the relation between innovation, tourism, information technology (internet, smart tourism, innovative technology), stakeholders (governments, organizations, municipalities, communities), tourism experience, tourism destination, tourism services, product innovation, competitiveness advantages, economic development, performance, cultural heritage, rural area, ecotourism.
Shepherding the Shepherd in the Midst of a Pandemic
Authors: Abraham Shini 
Published: May 2023

Abstract
This essay explores two key themes in practical theology. First, I offer an evaluation of how ministers fared through the COVID-19 pandemic and consider its impact on life and ministry via reflection on literature as well as on my own practice as a pastoral care worker who “shepherds the shepherd.” Ministers encountered in my line of work frequently display symptoms of burnout. In exploring whether pandemic-related stresses contributed to this burnout, I found that prepandemic studies consistently identified a higher risk of burnout in ministers than people in the general population. This begged the question, why are ministers more susceptible to burnout? Within the scope of this essay, I explore this question via theological reflection.
Secondly, in exploring the importance of spiritual disciplines, specifically the Judeo-Christian idea of Sabbath in preventing burnout, I propose adding the idea of Sabbath rest to theological reflection models and present my rationale for how this contributes to health and flourishing in life, praxis, and theological reflection.
Path Loss Prediction Accuracy Based On Random Forest Algorithm in Palembang City Area
Authors: Sukemi Sukemi , Ahmad Fali Oklilas  , Muhammad Wahyu Fadli  , Bengawan Alfaresi  
Published: May 2023

Path loss is a mechanism where the signal from the transmitting antenna to the receiver in a wireless network is attenuated during transmission across a medium due to external field conditions. In the telecommunication design, precise and efficient calculations are required. Random forest, as a machine learning-based path loss prediction model, is used in this study. Machine learning-based path loss prediction, random forest, has a low level of complexity and a high level of predictability. The data was collected using the drive test method at the Trans Musi busway area on the 4G network in Palembang, South Sumatra, Indonesia. The data ratio comprised 20% of the testing set and the rest of the training set. As a result, it was obtained that the prediction accuracy of 9.24% of mean absolute percentage error (MAPE) and root mean square error (RMSE) was 13.6 decibels (dB). Using hyperparameter tuning for random forest results in optimizing the model used, resulting in accuracy prediction for 8.00% of MAPE and RMSE was 11.8 dB, which is better than the previous results.
Voltage Stability Analysis of Power System with Photovoltaic Power Plant
Authors: Adrianti Adrianti , Putri Rada Tamara , Nasir Muhammad 
Published: May 2023

Photovoltaic power plants usually do not provide reactive power output; hence the application of large photovoltaics in power systems will decrease the voltage stability level of the power system. Capacitor banks can provide reactive power to compensate the photovoltaic plants; therefore, capacitor banks can overcome the reactive power deficiency of photovoltaic plants. However, the effect of capacitor bank installation on the system’s voltage stability is unknown. Therefore, the research aims to investigate whether installing a capacitors bank can restore the level of system voltage stability. The study employs the method of Voltage Stability Margin and transient stability simulation to the IEEE 9 bus system. The IEEE 9 bus system is modified where one generator of the system is replaced with a photovoltaic plant, and a capacitor bank is also installed. The study results show that the modified system voltage stability level is lower than the original system. When the capacity of the capacitor bank is increased to the maximum allowable value, the voltage stability level rises. However, it is still unable to be restored to its original value.
Inhaled iloprost as an add-on therapy for advanced pulmonary arterial hypertension: An Indian perspective
Authors: BOBHATE PRASHANT , GUPTA RAJAT KUMAR , KARANDE TANUJA , KULKARNI SNEHAL 
Published: May 2023

Background
Pulmonary arterial hypertension (PAH) is a progressive disease with high morbidity and mortality. Risk stratification and initiation of dual or triple combination therapy has a better clinical response, especially in high-risk patients. Unfortunately, prostacyclin analogues are not marketed in India; hence, the use of these medications is limited. We report the benefits and difficulties of using iloprost inhalation in patients with advanced PAH in India.

Methods
In this prospective observational study, we included patients with group 1 PAH. Inhaled iloprost was initiated as an add-on therapy for patients who had clinical, echocardiographic or laboratory deterioration on dual oral medications. Patients with clinical instability were excluded. All patients underwent thorough clinical evaluation, detailed echocardiogram and laboratory investigations. Patients were started on inhaled iloprost 2.5 μg six times daily and closely followed up. The dose was escalated if necessary. On follow-up, clinical echocardiographic and laboratory evaluation was done on all patients.

Results
Fourteen patients (11 women) with a median age of 32 years (2–66 years) with group 1 PAH were started on inhaled iloprost as an add-on therapy. Improvement in clinical parameters, WHO functional class, echocardiographic-derived right ventricular function, and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels were observed in 10 of 14 patients. A median increase of 31% (4.2, 106%) in the distance travelled during 6-minute walk test, a median increase of 45% (–20, 120%) in right ventricular fractional area change, a median increase of 27% (–16.7, 60%) in tricuspid annular peak systolic excursion and a median decrease of 36.7% (–69.6, 17.2%) in NT-pro-BNP levels were observed after initiation of medication. Three patients had progression of symptoms and were then referred for lung/heart–lung transplant. One patient developed progression of symptoms after an excellent initial response and transitioned to subcutaneous treprostinil. Improvement in clinical, echocardiographic and laboratory features allowed us to successfully perform surgical Potts shunt in 2 patients. The medications were well tolerated with minimal and transient side-effects. There were no deaths.

Conclusion
Inhaled iloprost can be used with acceptable benefits and minimal side-effects in patients with PAH.
Mapping the distribution and trends of co-circulating dengue virus serotypes in Odisha, India: A retrospective facility-based analysis
Authors: LABALA SALONI , SINHA ABHINAV , PANDA SAILENDRA , TURUK JYOTIRMAYEE , PATI SANGHAMITRA , SAHOO PRAKASH KUMAR 
Published: May 2023

Background
Dengue, caused by mosquito bite, is an emerging disease of international concern. Evidence regarding the prevalent dengue serotypes is scarce, but essential for its management during the outbreaks. Hence, we mapped the distribution and trends of currently prevalent dengue virus (DENV) serotypes in Odisha.

Methods
We conducted a facility-based retrospective study from referral samples sent for the diagnosis/confirmation of dengue in 2018. The samples were serologically tested for enzyme-linked immunosorbent assay (ELISA) IgM antibody and NS1. Only NS1-positive samples were chosen for sero-typing. A pool of 8–10 NS1-positive samples were analysed for district-wise serotypes. Ribonucleic acid extraction and nested polymerase chain reaction (PCR) was done from NS1-positive samples. The PCR products were then subjected to gel electrophoresis.

Results
A total of 2892 samples were screened for dengue virus across various districts of Odisha where 763 samples were found to be NS1-positive. Thirteen of 18 districts covering all topographies of Odisha predominantly had DENV2 serotype. Only few districts such as Balangir, Kalahandi and Rayagada had mixed serotypes.

Conclusion
Although DENV2 is predominantly prevalent, mixed serotypes too exist in Odisha. Evidence based on variations of dengue serotypes across topographies, seasons, gender and age groups may support public health efforts in preventing the disease.
Instructors' perception of the competencies required to teach DS in HEI
Authors: Msweli Nkosikhona 
Published: May 2023

While data science education may be a solution in democratising data science, there are challenges towards achieving this. One of the challenges is the shortage of qualified academic staff members, who are able to deliver a multidisciplinary curriculum.Teaching data science is a developing topic and represents a gap in the literature as we embark on the journey of discovering the knowledge required to teach data science. This study aimed to gain insight into instructors’ perceptions on their skills and competencies in teaching data science
Вплив помилок вимірювань, що повільно змінюються, на помилки оцінок параметрів траєкторії цілі
Authors: Піскунов С. М. , Шевченко А. Ф. , Дергоусов М. Ю. , Самоквіт В. І. 
Published: May 2023

Розглядаються шляхи отримання чисельної оцінки впливу помилок вимірювань, що повільно змінюються, на оцінки параметрів траєкторії цілі розрахованих за допомогою фільтра Калмана. Помилки вимірювань, що повільно змінюються, зумовлені неточністю юстування РЛС, дефектами її пристроїв та не стаціонарністю середи розповсюдження електромагнітних хвиль, і залежать від координат цілі, що істотно ускладнює розрахунки і не дозволяє отримати практично реалізовані методи їх врахування при фільтрації. Тому на практиці для виключення залежностей, що описують помилки вимірювань, що повільно змінюються, поточних координат цілі, розкладають помилки в ступеневий ряд поблизу середини інтервалу спостереження і обмежуються першими членами розкладання. Отримані співвідношення для оцінок кореляційних матриць помилок фільтрації методом найменших квадратів по фіксованій вибірці вимірювань мають граничний характер. Отримання розрахункових формул при дискретних вимірюваннях викликає значні математичні труднощі. Однак при достатньо малому інтервалі між вимірюваннями, тобто при високій частоті повторення зондування по цілі, ці вирази дозволяють отримати прийнятне наближення до реальних помилок. В роботі показано, що покращення точності характеристик РЛС приводить до покращення її пропускної спроможності. Розрахунок пропускної спроможності РЛС із використанням запропонованої методики показав, що врахування впливу помилки вимірювання, що повільно змінюється, дозволить збільшити її на (6–15) %. Розкид в значеннях збільшення пропускної спроможності пов'язаний зі ступенем знання статистичних характеристик помилки вимірювання, що повільно змінюється. Показано, що покращення характеристик точності РЛС приводить до збільшення ймовірності ураження повітряної цілі. Проведені розрахунки ймовірності ураження цілі показали, що за рахунок врахування впливу помилки вимірювання, що повільно змінюється, її можливо збільшити на (10–25) %.
Kualitas Kinerja Guru Ditinjau dari Pengaruh Inservice Training
Authors: Sari Tri Novita , Ahmad Syarwani , Rohana Rohana 
Published: May 2023

The purpose of this research is to find out and analyze how inservice training has an influence on improving the quality of teacher performance. This research uses quantitative methods and is included in survey research. Data collection techniques in this study were through the dissemination of questionnaires. The sample used in this study was 88 teachers of Madrasah Tsanawiyah in East Prabumulih District. Based on the findings of the study, it shows that inservice training has an influence on improving the quality of teacher performance. Research related to inservice training has never been studied before at the Madrasah Tsanawiyah in Prabumulih City. In addition, the novelty in this study is related to inservice training research conducted after the Covid 19 pandemic. This research contributed to the Head of Madrasah, Islamic Education of the Ministry of Religious Affairs of the Republic of Indonesia, and Teachers.
НЕРІВНОСТІ КОШІ-БУНЯКОВСЬКОГО І ГЕЛДЕРА ТА ЇХНЄ УЗАГАЛЬНЕННЯ
Authors: Бохонов Юрій , Бохонова Тетяна 
Published: May 2023

Формулювання проблеми. Класичним нерівностям присвячена різноманітна математична література. Нерівності Коші-Буняковського та Гелдера лежать в основі геометрії унітарних та нормованих просторів. У статті розглянуто узагальнення цих конструкцій – полілінійні форми і нерівності для них. Зміст узагальнених нерівностей полягає в оцінці полілінійної форми від системи векторів через їхні норми. Сама форма за зовнішнім виглядом є узагальненням скалярного добутку від довільної кількості векторів. Суттєво, що доведення проводяться елементарними методами, без використання засобів математичного аналізу. Відомо, що нерівність Коші-Буняковського є частинним випадком нерівності Гелдера. В роботі показується, що навпаки, другу з цих нерівностей може бути виведено з першої. Застосування доведених нерівностей до конкретних векторів дає одержання відомих результатів, зокрема, нерівності для середніх степеневих і деяких інших, які авторам не зустрічались у математичній літературі. Нерівності можуть бути перенесені на вектори з нескінченновимірних просторів послідовностей. Їх можна застосовувати також для пошуку екстремуму деяких функцій і при підготовці до олімпіад.
Матеріали і методи. Для доведення узагальненої нерівності Коші-Буняковського використано нерівність Коші для невід’ємних чисел, що є координатами векторів багатовимірного простору. При певному виборі таких векторів з цієї нерівності доводиться узагальнена нерівність Гелдера. Вибираючи вектори різноманітними способами, можна одержати різні змістовні нерівності.
Результати. Доведено узагальнені нерівності Коші-Буняковського, Гелдера, нерівність для середніх степеневих та деякі інші.
Висновки. Застосування узагальнених нерівностей Коші-Буняковського і Гелдера до різних систем векторів з невід’ємними координатами дає нерівності – як вже відомі, так і нові і досить змістовні. Їхнє доведення зводиться лише до вибору потрібної системи векторів. На цьому шляху вдається легко доводити нерівності, які можна зустріти на математичних олімпіадах.
NUEVAS DIANAS MOLECULARES EN CÁNCER DE GINECOLÓGICO
Authors: Leiva-Suero Lizette Elena , Salazar-Garcés Luis Fabián , Quishpe-Jara Graciela de las Mercedes , Fernández Gerardo , Villacís Valencia Sandra Elizabetn , Chicaiza Tayupanta Jesús Onorato 
Published: May 2023

Introducción: El cáncer cérvico uterino es la segunda enfermedad oncológica más frecuente en la mujer a nivel mundial, con diagnóstico de más de 83000 casos nuevos anualmente y más de 30000 muertes, se estima un incremento del 45% para el año 2030. Objetivo: caracterizar marcadores genéticos e inmunológicos con valor diagnóstico, pronóstico y terapéutico en el cáncer de cuello uterino. Métodos: Investigación aplicada, un estudio explicativo, longitudinal y prospectivo, que utilizó métodos estadísticos descriptivos e inferenciales. Resultados: Se logró identificar una alta prevalencia de infección por el Virus del Papiloma Humano, así como la disminución de la positividad de las proteínas BAX y Bcl-2 durante la progresión de la enfermedad neoplásica, como expresión de un desequilibrio en los mecanismos reguladores de la cascada apoptótica y alteración de las vías de señalización celular, como base para el desarrollo de inmunoterapias adyuvantes dirigidas a estas dianas moleculares. Conclusiones: La disminución de la la expresión de las proteínas BAX y Bcl-2 durante la progresión del cancer cervico uterino, evidencia un deterioro en los mecanismos de apoptosis y pudieran considerarse como dianas moleculares para el desarrollo de inmunoterapias adyuvantes con impacto en la progresión de la enfermedad oncológica y la supervivencia atribuible.
Palabras clave: neoplasias del cuello uterino, apoptosis, proteína de susceptibilidad a apoptosis celular
ABSTRACT
Introduction: Cervical cancer is the second most frequent oncological disease in women worldwide, with more than 83,000 new cases diagnosed annually and more than 30,000 deaths, an increase of 45% is estimated by 2030. Objective: characterize genetic and immunological markers with diagnostic, prognostic and therapeutic value in cervical cancer. Methods: Applied research, an explanatory, longitudinal and prospective study, which used descriptive and inferential statistical methods. Results: It was possible to identify a high prevalence of infection by the Human Papillomavirus, as well as the decrease in the positivity of BAX and Bcl-2 proteins during the progression of neoplastic disease, as an expression of an imbalance in the regulatory mechanisms of the apoptotic cascade and alteration of cell signaling pathways, as a basis for the development of adjuvant immunotherapies targeting these molecular targets. Conclusions: The decrease in the expression of BAX and Bcl-2 proteins during the progression of cervical cancer evidences a deterioration in the mechanisms of apoptosis and could be considered as molecular targets for the development of adjuvant immunotherapies with impact on the progression of oncological disease and attributable survival.
Keywords: uterine cervical neoplasms, apoptosis, cellular apoptosis susceptibility protein
ENVIRONMENTAL SIGNIFICANCE OF FOULING ON THE CRUDE OIL FLOW. A COMPREHENSIVE REVIEW
Authors: Abdulhussein Zaid , Al-sharify Zainab , Alzuraiji Mohammed , Onyeaka Helen 
Published: May 2023

Investigating important challenges to eliminate crude oil fouling in pipelines needs to be studied thoroughly. According to environmental and economic issues, fouling in pipelines increases the price of crude oil. According to chemical and environmental experts, the loss in heat required additional energy to compensate which meant higher fuel consumption and more carbon emissions into the atmosphere. The increase in fluid flow rate combined with a constant drop in pressure is dangerous for pipelines. In addition, the Iraqi crude oils block refinery preheat trains because they contain very little asphaltene. The fouling of a variety of these crude oils and their blends is examined in this paper. Fouling may be caused by four major processes: solid particles, corrosion, sedimentation, and chemical reaction.