bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrochemical characteristics and water quality evaluation for irrigation and drinking purposes of Bangong Co Lake Watershed
Authors: Shao Yuxiang , Yan Buqing , Liu-Lu Baiyang , Feng Gang , Zhang Kun , Gong Kang 
Published: March 2023

Abstract
In order to explore the hydrochemical characteristics, influencing factors, and water quality of various water bodies in Bangong Co Lake Watershed, 60 water samples were collected from lake, river, groundwater, glacier water bodies in the watershed. Piper diagram, Gibbs’ diagrams, ion ratio analysis, statistical methods, and principal component analysis were used to study the hydrochemical characteristics and its influencing factors. Drinking water quality index (DWQI) and USSL classification were applied to assess the groundwater quality suitability for agricultural and drinking purposes. The hydrochemical characteristics show the differences among water bodies and their spatial distribution. Analyzed groundwater and surface water samples such as river water and glaciers mainly presented Ca-HCO3 type, and lake water mainly presented Na-Cl type and a small number of Na-HCO3·Cl type. The lake water chemical components are mainly affected by evaporative karst decomposition. The main mineralization process of groundwater and river water was related to the dissolution of reservoir minerals such as dolomite and calcite, and halite. The DWQI indicates that 79% of the groundwater samples in the study area showed a good quality for drinking. For irrigation water quality, the electrical conductivity (EC), calculated Sodium adsorption ratio (SAR), Magnesium hazardous ratio (MHR) showed that more than 13% of the total samples were not suitable for irrigation. USSL classification indicated that glacier and river water are relatively suitable for irrigation. And part of the groundwater and lake water has very high alkalinity or salinity which is alarming when considered for irrigation.
Risk factors and nomogram model of postoperative delirium in children with congenital heart disease: a single center prospective study
Authors: Mao Dou , Fu Lijuan , Zhang Wenlan 
Published: March 2023

Abstract
Objective Delirium is a common postoperative complication in children with congenital heart disease, which affects their postoperative recovery. The purpose of this study is to explore the risk factors of delirium and construct nomogram model to provide reference for the prevention and management of postoperative delirium in children with congenital heart disease.
Methods 470 children after congenital heart surgery treated in the cardiac intensive care unit(CICU) of Shanghai Children's Medical Center were divided into model group and verification group according to the principle of 7:3 distribution, the delirium related influencing factors of 330 children in the model group were analyzed, the nomogram model was established by lasso regression and logistic regression; The data of 140 children in the validation group were used to verify the effect of the model.
esults Multivariate logistic regression analysis showed that age, disease severity, noninvasive ventilation after tracheal intubation extraction, delayed chest closure, phenobarbital dosage, promethazine dosage, mannitol and high fever were independent risk factors for postoperative delirium; The area under the receiver operating characteristic curve(AUC) of the nomogram model was 0.864 and the Brier value was 0.121; Validation of model effect: The results showed that 51 cases were predicted by the model and 34 cases were actually occurred, including 4 cases of false negative and 21 cases of false positive. The positive predictive value was 58.8%, the negative predictive value was 95.5%.
Conclusions The nomogram model constructed in this study showed acceptable performance of predicting postoperative delirium in children with congenital heart disease.
Novel Pedestrian Detection and Suspicious Activity Recognition Using Enhanced YOLOv5 and Motion Feature Map
Authors: Gawande Ujwalla Gawande Ujwalla , Hajari Kamal Hajari Kamal , Golhar Yogesh 
Published: March 2023

Abstract
Pedestrian detection and suspicious activity recognition are notable challenges in vision-based surveillance systems. However, the accuracy of pedestrian detection is influenced by a wide range of factors, including human presence, trajectory, posture, complex background, and object deformation. In this paper, we developed a pedestrian dataset that encompasses student behavior in an institution, such as cheating, stealing lab devices, dispute, and threatening scenarios. It provides uniform and steady identification annotations of pedestrians, making it suitable for pedestrian detection, tracking, and behavior detection. In addition, we also improved detection accuracy using the enhanced YOLOv5 architecture. Next, we proposed an efficient method for detection of global and local unusual behaviors. The proposed method extracts motion features that accurately describe pedestrian motion, speed, and direction, etc. The proposed method is validated on a proposed student behavior database and three additional publicly available benchmark datasets. It gives state-of-the-art detection accuracy of 96.12% and miss rate of 6.68% compared to the existing techniques. The experimental results demonstrate a substantial performance improvement in anomalous activity recognition. The final section summarizes and discusses future research directions.
Comparison of Doppler and oscillometric methods of assessing ankle-brachial index in non-diabetic premenopausal women in Ghana
Authors: Agyekum Jennifer Adjepong , Oblitey Jared Nii , Yeboah Kwame 
Published: March 2023

Abstract

Introduction

Peripheral arterial disease (PAD) is a common cardiovascular disease less commonly diagnosed in female patients. PAD is objectively diagnosed using the ankle-brachial index (ABI), which can be measured using the ‘gold standard’ Doppler method or the oscillometric method. The agreement between these two methods is less investigated in sub-Saharan African poplation. Therefore, we compared the diagnostic characteristics of the oscillometric method of measuring ABI with the Doppler method in premenopausal female patients suspected of PAD in Ghana.

Method

ABI was measured in non-diabetic premenopausal women suspected of PAD using the Doppler method with a 8 MHz handheld Doppler (LifeDop 250, Summit Doppler) and an oscillometric device (Vasera 1500N, Fukuda Denshi) in 160 patients (320 legs). PAD was defined as ABI < 0.9 in at least one leg. Leg pains were assessed using the Edinburgh claudication questionnaire.

Results

Leg pain on exertion was present in 101 patients screened with similar mean ABIs in the right and left legs. The prevalence of PAD as screened by the Doppler method was 25.7% (18.9–33.4%) and that of the oscillometric method was 32.2% (24.9–40.3%). In comparison to the Doppler method, the accuracy of the oscillometric method was 88.2%, with sensitivity, specificity, positive and negative predictive values of 89.7%, 87.6%, 71.4% and 96.1%, respectively. The overall agreement between the Doppler and oscillometric methods was high [\(\kappa\)=0.78 (0.62–0.91), p < 0.001] and intraclass correlation of 0.89 (0.87–0.92, p < 0.001). In ROC curve analysis, the oscillometric method showed an area under curve of 0.925 compared to the Doppler method in the diagnosis of PAD.

Conclusion

In nondiabetic premenopausal women in our study, oscillometric ABI performed acceptably in the diagnosis of PAD when compared with Doppler ABI.
Intraoperative awareness with recall during General Anesthesia in Damascus University Hospitals in Syria (A Cohort Study).
Authors: Rekmani Najwa 
Published: March 2023

Abstract
Background
Awareness with recall during general anesthesia is one of the frightening complications of general anesthesia, which indicates the failure of anesthesia. Awareness is an underestimated complication despite the fact that it sometimes carries devastating psychological risks for patients. To our knowledge this is the first research in Syria that reports the incidence of awareness with recall during general anesthesia.
Aims
to assess the incidence of awareness with recall during general anesthesia in Damascus University teaching hospitals.
Design:
multi-central prospective cohort study.
Setting:
Three main Teaching Hospitals of Damascus University: Al-Assad, Al-Mowassat & Maternity Hospitals during the time period between January and November 2021.
Study Sample:
3500 patients aged ≥ 18 years were included.
Results
the incidence of Awareness with recall during general anesthesia in Damascus University Teaching Hospitals was 0.66% in low risk of awareness surgery and 1.8% in high risk of awareness surgeries. The most frequent manifestations of awareness were auditory perceptions, paralysis and pain (100%, 100% & 97.4% respectively).
Conclusions
Awareness with recall rate was somehow high in Damascus University Teaching Hospitals in comparison to the figures reported by American and European studies, this difference was especially noted in a low risk of awareness surgery. The rates were similar in the high risk of awareness surgeries. Lack of premedication and low concentration of inhalational agent were the main reasons for awareness.
Berlin Sefiri İbrahim Hakkı Paşa’nın I. Dünya Savaşı Hakkında Bilinmeyen İki Raporu (1916)
Authors: KARACAGİL Ö. Kürşad 
Published: March 2023

Türk-Alman ilişkileri uzun bir tarihi geçmişe sahiptir. İlişkilerde önemli dönüm noktalarından birisi ve belki de en önemlisi, Türk tarihine, Harb-i Umumi ya da Cihan Harbi olarak geçen I. Dünya Savaşına müttefik olarak girilmesidir. Savaş içerisinde de ilişkilerin gelişmesine önem veren iki ülke, en tecrübeli bürokratlarını büyükelçi/ Sefir-i Kebir olarak görevlendirmişlerdir. Bu bağlamda, Osmanlı Devleti, Sadrazamlık dahil olmak üzere birçok üst düzey görevde bulunan, Darülfünunda verdiği dersler ve kitaplarıyla bilinen, batıyı ve batılı fikirleri iyi tanıyan İbrahim Hakkı Paşa’yı 21 Temmuz 1915’te Berlin’e Sefiri Kebir olarak atamıştır. Hakkı Paşa bu görevi Temmuz 1918 tarihine yani vefatına kadar sürdürmüştür.
Makalede, İbrahim Hakkı Paşa’nın bizzat kaleme aldığı iki rapor tartışılacaktır. Raporlar, 3 ve 11 Ocak 1916 tarihlerinde yani I. Dünya Savaşı’nın ortalarında yazılmış; “mahremane” ibaresiyle Osmanlı Hariciye Nezareti yollanmıştır. Raporlar birbirini tamamlar niteliktedir. Raporlarda, I. Dünya Savaşında yaşanan gelişmeler bağlamında, ateşkes, Almanya’nın savaşa bakışı, cepheler ve burada yaşanan gelişmeler, savaşın hangi devlet ya da devletler mağlup edilirse İttifak devletlerince kazanılabileceği tartışması yapılmıştır. Hatta bazı noktalarda Almanya’ya karşı eleştiriler dahi bulunmaktadır. Dönemin Osmanlı yönetimi açısından hayati öneme sahip olan bütün bu bilgiler, bizzat Berlin’de bulunan ve savaşı Almanya’nın başkentinden müşahede etme imkânına sahip olan bir Osmanlı Sefiri gözünden ele alınmıştır.
Anahtar Kelime: Birinci Dünya Savaşı, Almanya, Osmanlı Devleti
Direct Oral Anticoagulants for the Prevention and Treatment of Venous
Thromboembolic Events in Cancer Patients: A Meta-analysis of Randomized
Controlled Trials
Authors: Al-Mansouri Loma , AL-Obaidi Firas R. , Bashir  Altaweel Rafid , Soto-Perez-de-Celis Enrique , Al- Farhan Hasan , A Abdullah Noor , Alrubaiy Laith 
Published: March 2023

Introduction::
Cancer is associated with a higher risk of venous thromboembolic events
compared to the general population. About one-fifth of patients diagnosed with venous thromboembolic
events have underlying cancer. The guidelines recommend both low molecular weight heparin
and direct oral anticoagulants for the prevention and treatment of venous thromboembolic events.
Further evidence is required to adequately characterize the exact role of direct oral anticoagulants.

Methods::
A systematic review of the literature was done by searching the databases of Medline,
Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov. The analysis
included only randomized controlled trials enrolling adult patients with cancer and venous thromboembolic
events comparing low molecular weight heparin versus direct oral anticoagulants. Duration
of follow-up of at least 6 months was considered as a minimum. The studies had to assess the risk of
thromboembolic recurrence rate, all-cause mortality, and risk of bleeding.

Results::
The final search results led to the inclusion of five randomized controlled trials. The analysis
showed a similar risk of recurrence of venous thrombotic events (RR 0.71, 95% CI 0.44-1.17; p =
0.18), mortality risk (RR 1.02, 95% CI 0.88-1.17; p = 0.8), and major bleeding (RR 1.05, 95% CI
0.69-1.62; p = 0.81) between the two treatment groups.

Conclusion::
The use of direct oral anticoagulants is a feasible and practical option in ambulatory
cancer patients with venous thromboembolic events. The efficacy and safety are similar to that of low
molecular weight heparin.
Antheraea proylei J. Sericin Induces Apoptosis in a Caspase-dependent Manner in A549 and HeLa Cells
Authors: Devi Potsangbam Jolly , Singh Asem Robinson , Singh Naorem Tarundas , Singh Laishram Rupachandra , Devi Sanjenbam Kunjeshwori , Singh Lisam Shanjukumar 
Published: March 2023

Background::
In spite of much progress in cancer, the global cancer burden is still significant and increasing.
Sericin, an adhesive protein of silk cocoons, has been shown to be a potential protein in various biomedical applications,
including cancer therapeutics. The present study evaluates the anticancer property of sericin from cocoons of
Antheraea proylei J (SAP) against human lung cancer (A549) and cervical cancer (HeLa) cell lines. This is the first
report of anti-cancer activity of the non-mulberry silkworm A. proylei J.

Objective::
Establish the antiproliferative potential of SAP. 2. Identify the molecular mechanism of cell death induced
by SAP on two different cell lines

Aims::
To investigate the anticancer activity of sericin preparation from cocoons of A. proylei.

Methods::
SAP was prepared from cocoons of A. proylei J. by the process of the degumming method. Cytotoxic activity
was assessed by MTT assay, and genotoxicity was assessed by comet assay. Cleavage of caspase and PARP proteins
and phosphorylation of MAPK pathway members were analysed by Western blotting. Cell cycle analysis was done by
flow cytometer.

Results::
SAP causes cytotoxicity to A549 and HeLa cell lines with the IC50 values 3.8 and 3.9 μg/μl respectively. SAP
induces apoptosis in a dose-dependent manner through caspase-3 and p38, MAPK pathways in A549 and HeLa cells.
Moreover, in A549 and HeLa cells, SAP induces cell cycle arrest at the S phase in a dose-dependent manner.

Conclusion::
The difference in the molecular mechanisms of apoptosis induced by SAP in A549 and HeLa cell lines
may be due to the difference in the genotypes of the cancer cell lines. However, further investigation is warranted. The
overall results of the present study envisage the possibility of using SAP as an anti-tumorigenic agent.
Moisturizer and COVID-19: Are We Missing a Trick?
Authors: Galiveti Chenna R. , Tantravahi Srinivasan 
Published: March 2023

Abstract:
Corona Virus Disease 2019 (COVID-19) is reported to be transmitted predominantly by respiratory
droplets and fomites. The regular use of a mask can mitigate the airborne transmission of the Severe
Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), but comprehensive prevention of the virus
is possible only when the contact spread of the virus is also addressed. The recommended use of soap and
hand sanitizer (alcoholic hand rub) is effective only until subsequent contact with the virus. Furthermore,
regular and repeated application of these disinfectants is impractical and harmful to the skin. The damage
to the outermost epidermal layers of the skin exposes the Angiotensin-converting enzyme 2 (ACE2) receptor
rich keratinocytes, enhancing the scope for percutaneous transmission of virus. Moisturizers, composed
of fatty acids, fatty alcohols, mineral oils, petrolatum, etc., are generally considered cosmetics used
to maintain and enhance skin condition. At very low concentrations, several of these components are
found to neutralize enveloped viruses, indicating their potential antiviral activity. Soaps also generally
contain many of these constituents, making them effective against viruses. Petrolatum, a key component
of occlusive moisturizers, is also said to enhance innate immunity. Additionally, moisturizers also alleviate
inflammation and prevent skin dryness and damage. The periodic and regular application of an appropriate
moisturizer on hand and palm can play a significant role in curtailing the transmission of infectious
agents, including (SARS-CoV-2), and could act as an extra line of defense against microbial infections.
Visões de educadoras de educação ambiental para o desenvolvimento sustentável: Entre o empoderamento e a orientação de crianças e jovens
Authors: Menezes Isabel , Rios Clementina , Neilson Alison 
Published: March 2023

Esta investigação visa desocultar as visões de educadoras sobre a educação ambiental para o desenvolvimento sustentável (EADS), relacionando práticas e o papel das crianças na promoção da cidadania ambiental, por forma a caraterizar a implementação da EADS em escolas com diferentes programas e pedagogias ambientais. Foi realizado um estudo de casos múltiplos, em eco-escolas, escolas da floresta, Krishnamurti e Waldorf. As entrevistas foram realizadas a educadoras de EADS no pré-escolar e no ensino básico. Os resultados apontam diferenças não só pelas pedagogias e programas que orientam a EADS, mas também pela influência do contexto geográfico e sociocultural. A sustentabilidade ambiental é um dos aspetos mais trabalhados pelas educadoras, embora umas foquem mais as condutas pró-ambiente e outras uma preocupação com formas de vida autossustentáveis. Outro resultado importante é o amor incondicional de humanos e não humanos, como relação que permite a conexão com a natureza.
Technology-Assisted Cognitive Motor Dual-Task Rehabilitation in Chronic Age-Related Conditions: Systematic Review
Authors: Tuena Cosimo , Borghesi Francesca , Bruni Francesca , Cavedoni Silvia , Maestri Sara , Riva Giuseppe , Tettamanti Mauro , Liperoti Rosa , Rossi Lorena , Ferrarin Maurizio , Stramba-Badiale Marco 
Published: March 2023

Background
Cognitive-motor dual-task (CMDT) is defined as the parallel processing of motor (eg, gait) and cognitive (eg, executive functions) activities and is an essential ability in daily life. Older adults living with frailty, chronic conditions (eg, neurodegenerative diseases), or multimorbidity pay high costs during CMDT. This can have serious consequences on the health and safety of older adults with chronic age-related conditions. However, CMDT rehabilitation can provide useful and effective therapies for these patients, particularly if delivered through technological devices.

Objective
This review aims to describe the current technological applications, CMDT rehabilitative procedures, target populations, condition assessment, and efficacy and effectiveness of technology-assisted CMDT rehabilitation in chronic age-related conditions.

Methods
We performed this systematic review, following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, on 3 databases (Web of Science, Embase, and PubMed). Original articles that were published in English; involved older adults (>65 years) with ≥1 chronic condition and/or frailty; and tested, with a clinical trial, a technology-assisted CMDT rehabilitation against a control condition were included. Risk of bias (Cochrane tool) and the RITES (Rating of Included Trials on the Efficacy-Effectiveness Spectrum) tool were used to evaluate the included studies.

Results
A total of 1097 papers were screened, and 8 (0.73%) studies met the predefined inclusion criteria for this review. The target conditions for technology-assisted CMDT rehabilitation included Parkinson disease and dementia. However, little information regarding multimorbidity, chronicity, or frailty status is available. The primary outcomes included falls, balance, gait parameters, dual-task performance, and executive functions and attention. CMDT technology mainly consists of a motion-tracking system combined with virtual reality. CMDT rehabilitation involves different types of tasks (eg, obstacle negotiation and CMDT exercises). Compared with control conditions, CMDT training was found to be pleasant, safe, and effective particularly for dual-task performances, falls, gait, and cognition, and the effects were maintained at midterm follow-up.

Conclusions
Despite further research being mandatory, technology-assisted CMDT rehabilitation is a promising method to enhance motor-cognitive functions in older adults with chronic conditions.
Mobile Assessments of Mood, Cognition, Smartphone-Based Sensor Activity, and Variability in Craving and Substance Use in Patients With Substance Use Disorders in Norway: Prospective Observational Feasibility Study
Authors: Lauvsnes Anders Dahlen Forsmo , Hansen Tor Ivar , Ankill Sebastian Øiungen , Bae Sang Won , Gråwe Rolf W , Braund Taylor A , Larsen Mark , Langaas Mette 
Published: March 2023

Background
Patients with substance use disorders (SUDs) are at increased risk for symptom deterioration following treatment, with up to 60% resuming substance use within the first year posttreatment. Substance use craving together with cognitive and mental health variables play important roles in the understanding of the trajectories from abstinence to substance use.

Objective
This prospective observational feasibility study aims to improve our understanding of specific profiles of variables explaining SUD symptom deterioration, in particular, how individual variability in mental health, cognitive functioning, and smartphone use is associated with craving and substance use in a young adult clinical population.

Methods
In this pilot study, 26 patients with SUDs were included at about 2 weeks prior to discharge from inpatient SUD treatment from 3 different treatment facilities in Norway. Patients underwent baseline neuropsychological and mental health assessments; they were equipped with smartwatches and they downloaded an app for mobile sensor data collection in their smartphones. Every 2 days for up to 8 weeks, the patients were administered mobile ecological momentary assessments (EMAs) to evaluate substance use, craving, mental health, cognition, and a mobile Go/NoGo performance task. Repeated EMAs as well as the smartphone’s battery use data were averaged across all days per individual and used as candidate input variables together with the baseline measures in models of craving intensity and the occurrence of any substance use episodes.

Results
A total of 455 momentary assessments were completed out of a potential maximum of 728 assessments. Using EMA and baseline data as candidate input variables and craving and substance use as responses, model selection identified mean craving intensity as the most important predictor of having one or more substance use episodes and with variabilities in self-reported impulsivity, mental health, and battery use as significant explanatory variables of craving intensity.

Conclusions
This prospective observational feasibility study adds novelty by collecting high-intensity data for a considerable period of time, including mental health data, mobile cognitive assessments, and mobile sensor data. Our study also contributes to our knowledge about a clinical population with the most severe SUD presentations in a vulnerable period during and after discharge from inpatient treatment. We confirmed the importance of variability in cognitive function and mood in explaining variability in craving and that smartphone usage may possibly add to this understanding. Further, we found that craving intensity is an important explanatory variable in understanding substance use episodes.