bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution of ABO and Rh blood groups in patients with endometriosis at King Abdulaziz University Hospital: A case control study
Authors: Alhammadi Maisam H. , Alsaif Afnan A. , Alghamdi Dalal A. , AlBasri Samera F. 
Published: March 2023

Abstract
Background: There is no sound evidence for the association of blood groups with the risk of endometriosis, and no studies from Saudi Arabia have examined this association. Therefore, the present aim was to determine whether there is an association between the distribution of ABO and Rh blood groups and the incidence of endometriosis in a cohort from Saudi Arabia.
Methods: Methods: This case-control study included women diagnosed with endometriosis (n = 44) who presented to King Abdulaziz University Hospital Obstetrics and Gynecology Clinic, Jeddah, Saudi Arabia, between 2010 and 2021. Women from the blood donors database of King Abdulaziz University Hospital were included as a control group (n = 184). The total sample size was 228. Demographic data, diagnosis method, ABO blood type, and Rh blood type were obtained from hospital records. In addition, data were collected from self-reported questionnaires, which included family history, dysmenorrhea, age of menarche, age of childbearing, number of children, history of abortion, parity, number of children, use of oral contraceptives for alleviating dysmenorrhea, iron deficiency, duration of menstrual flow, and volume of bleeding during menses. Odds ratio, Pearson chi-squared test (χ2), and independent t-test were used to analyze the associations between variables.
Results: Most of the participants had blood type O (n = 117, 51.3%), which was followed by blood type A (n = 59, 26.0%), and the majority were Rh+ (n = 215, 94.3%). There was no significant difference in the risk of endometriosis according to ABO (P = 0.237) and Rh (P = 0.283) blood types. However, endometriosis was found to have a significant relationship with dysmenorrhea, heavy bleeding during menses, history of abortion, long duration of menstrual flow, lower number of children, late pregnancy, and use of oral contraceptive pills to relieve dysmenorrhea (p ≤ 0.05).
Conclusions: The present results indicate that ABO and Rh blood types are not associated with the risk of endometriosis. However, there was a strong, significant association between endometriosis and other factors.
The dietary fiber and micronutrient composition of traditional foods from Lebanon and their contribution to dietary adequacy: A call for action
Authors: Hoteit Maha , Zoghbi Edwina , Rady Alissar , Shankiti Iman , Sacre Yonna , Hanna-Wakim Lara , Mahfouz Rana , Al-Jawaldeh Ayoub 
Published: March 2023

Abstract
Diet quality is a limiting factor to micronutrients sufficiency. The aim of this work is to evaluate, through chemical analysis, the dietary fibers and micronutrients content for vitamin A, D, E and C and their contributions to daily values in frequently consumed traditional dishes and Arabic sweets in Lebanon. Thirty types of traditional Lebanese dishes were collected from five central kitchens in the main Lebanese governorates and thirty-seven types of Arabic sweets were selected from popular confectionary stores. Among all the traditional dishes and Arabic sweets, 23% and 30% were considered good sources of dietary fibers, respectively. Vitamins A, D, E and C were found in trace levels in almost all traditional dishes and Arabic sweets.Micronutrients and dietary fibers are deficient in the Lebanese traditional dishes and Arabic sweets.
Treating peri-trochanteric hip fractures with intramedullary nail. When a second anti-rotational screw is necessary?
Authors: Tilaveridis Panagiotis , Iliopoulos Efthymios , Georgoulas Paraskevas , Drosos Georgios , Ververidis Athanasios , Tilkeridis Konstantinos 
Published: March 2023

Abstract
Introduction:
Fragility fractures around the proximal end of the femoral bone have been increasing the last years, increasing the pressure at the national health care systems and the hospital expenses. Peri-trochanteric fractures have been treated successfully with anatomic intramedullary nails of the proximal femur, giving a stable fixation in order to allow early mobilisation of these frail patients. Some of these nail allow a second (anti-rotational) screw through the nail in the femoral head. In the present study the use of this additional screw is studied, in terms of quality of reduction, mobilization and complications.
Materials & methods
All patients who were treated in the same hospital for peri-trochanteric fracture between January 2017 and December 2019 were included in the study. The patients were randomly assigned into group A, were the treatment included intramedullary nailing using one femoral hip screw, and group B, were the treatment included a second anti-rotational screw as well. The patients were followed up clinically and radiologically, for at least 3 months post-operatively. Demographic and operation data were collected alongside with radiographic and complication data.
Results
A total of 118 patients aged 82.7 years were included in the study after exclusions. There were no statistically significant differences between the two groups regarding the ASA grade, Nottingham Hip fracture score, Koval score, Mental score, operation time, transfusion and operative radiation dose and time (p > 0.05). In group A more complications were observed (p < 0.05). The radiological measurements were statistically significant different. CART analysis revealed that the use of a single screw in the femoral head for the subgroup of the unstable peri-trochanteric fractures (Jensen Type 4–5 – AO31A2.2 and above), has the tendency of developing more post-operative complications.
Conclusion
The use of an additional anti-rotational screw for the unstable peri-trochanteric fractures (Jensen Type 4–5 and AO 31A2.2 and above) could prevent complications such as varus collapse and cut-out.
Identifying energy model fingerprints in mitigation scenarios
Authors: Dekker Mark , Daioglou Vassilis , Pietzcker Robert , Rodrigues Renato , de Boer Harmen Sytze , Longa Francesco Dalla , Drouet Laurent , Emmerling Johannes , Fattahi Amir , Fotiou Theofano , Fragkos Panagiotis , Fricko Oliver , Gusheva Ema , Harmsen Mathijs , Huppmann Daniel , Kannavou Maria , Krey Volker , Lombardi Francesco , Luderer Gunnar , Pfenninger Stefan , Tsiropoulos Ioannis , Zakeri Behnam , Zwaan Bob van der , Usher Will , Vuuren Detlef van 
Published: March 2023

Abstract
Energy models are used to study mitigation pathways compatible with the Paris Agreement goals. These models vary in structure, objectives, parameterization, and level of detail, which yield differences in the computed mitigation pathways. To interpret model differences, diagnostic indicators are already common practice in many scientific fields, e.g., physical climate science1,2. However, they have not been applied systematically yet in climate mitigation literature, beyond addressing individual model dimensions3,4. We address this gap by quantifying energy model typology along five dimensions: 1) model responsiveness, 2) mitigation strategies, 3) energy supply, 4) energy demand, and 5) mitigation costs and efforts, each expressed in several diagnostic indicators. The framework is applied to a diagnostic experiment with eight leading energy models in which we explore ten scenarios focusing on Europe. Expressing the indicators relative to the full model-scenario ensemble yields a comprehensive “energy model fingerprint” that reveals patterns among models and indicators, and can be used to contextualize model differences in future model intercomparison studies.
Nitrogen deposition further increases Ambrosia trifida root exudates invasiveness under global warming
Authors: Xu Ke , Liu Xinyue , Zhao Changxin , Pan Qingmin , Chen Xiaoxing , Jiang Ning , Du Cuiping , Xu Yufeng , Shao Meini , Qu Bo 
Published: March 2023

Abstract
Invasive plants can change the soil ecological environment in the invasion area to adapt to their growth and reproduction through root exudates. Root exudates are the most direct manifestation of plant responses to external environmental changes, butthere is a lack of studies on root exudates of invasive plants in the context of inevitable global warming and nitrogen deposition. In this report, we used widely targeted metabolomics to investigate Ambrosia trifida root exudates during seedling and maturity under warming and nitrogen deposition to reveal the possible mechanisms of A. trifidaadaptation to climate change. The results showed that the organic acids increased under warming condition but decreased after nitrogen addition in the seedling stage. Phenolic acids increased greatly after nitrogen addition in the mature stage. Most phenolic acids were annotated in the phenylpropane metabolic pathway and tyrosine metabolism. Therefore, nitrogen deposition may increase the adaptability of A. trifida through root exudates, making it more invasive under global warming. The results provide new ideas for preventing and controlling the invasion of A. trifida under climate change.
WITHDRAWN: Physical and Mathematical Consistency of the Janus Cosmological Model
Authors: ZEJLI Hasnae , ZEJLI Hicham 
Published: March 2023

Abstract

The Janus Cosmological Model is based on a system of two coupled field equations. It explains the nature of dark matter and dark energy with negative mass and without the runaway paradox that arises in general relativity. We first recall how this system was built, from a simple Newtonian toy model to a relativistic bimetric theory, that is now improved in order to fulfill mathematical constraints and set up on a Lagrangian derivation.
Association of waist circumference with all-cause and cardiovascular mortality in diabetes from NHANES 2003-2014
Authors: Tian Tian , Geng Yang , Li Xuehui , Sun Xueli , Liu Yan , Pei Changjun , Wang Xin , Cao Ling , Chen Hui , Zhang Hengzhong , Wu Yumei , Song Bin 
Published: March 2023

Abstract
Background
In diabetes mellitus (DM), the relationship between waist circumference (WC) and mortality is scarce. Herein, we explored all-cause and cardiovascular mortality relationships with the baseline WC among individuals with DM.
Methods
US adults with DM (2256 women and 2427 men) from NHANES 2003–2014 who had WC measurement at the baseline were included. The national death index was employed to obtain their survival data from the enrollment till 2015. The mortality risk was calculated using multivariable Cox proportional hazards models, smooth curve fitting, and threshold effect analysis.
Results
Among a total of 4683 participants with diabetes, 346 women and 482 men died during the median follow-up of 5.7 and 5.4 years, respectively. With all-cause and cardiovascular mortality, WC exhibited a U-shaped association among females and a J-shaped trend among males. The adjusted hazard ratios (HRs) along with 95% confidence intervals (CIs) for all-cause mortality given WC values below and above 107.0 cm were 0.98 (0.96–0.98) and 1.03 (1.01–1.05), respectively, among women, and those below and above 89.5 cm were 0.91 (0.87–0.96) and 1.04 (1.02–1.05), respectively, among men.
Conclusions
WC presented a U-shaped relationship among women, and a J-shaped relation among men regarding all-cause and cardiovascular mortality among US adults with DM from NHANES.
Prevalence of oral Helicobacter pylori infection in an indigenous community in Southwest Mexico
Authors: Garza-Ramos Myriam Angelica De La , Gonzalez-Brosig Karen Ivonne , Salazar-Garza Alina Abigail , Gomez-Flores Ricardo , Tamez-Guerra Patricia , Urrutia-Baca Victor Hugo 
Published: March 2023

Abstract
Epidemiological studies have been conducted to improve the health and economic quality of life of indigenous communities in Mexico. These studies showed that infections cause frequent health problems. Helicobacter pylori are responsible for conditions ranging from gastritis to stomach cancer. This study determined the prevalence of H. pylori in families from Siltepec, Chiapas, Mexico. Ninety-nine dental plaque samples from 36 families were studied. Real-time PCR was performed to detect H. pylori using previously reported primers. The Mann-Whitney U test was used for the statistical analysis. According to the family role of H. pylori-positive individuals, the VacA s1/m1 genotype and CagA gene correlated. The mother had the highest expression of VacA s1/m1-/cagA- with 19% (8/42), followed by the first child with 14.3% (6/42). The major roles for the vacA s1/m1+/cagA- were the mother and first child with 9.5% (4/42), followed by the remaining children with 4.8% (2/42). The vacA s1/m1-/cagA + genotype was 7.1% (3/42) for the mother and 4.8% (2/42) for the father. Finally, the vacA s1/m1+/cagA + genotype only appeared in the mother, son I, and son III with 2.4% (1/42). The vacA s1/m1/cagA genotypes predominated in the mother, suggesting potential transmission between the mother and child during the first years of life.
Optimizing cancer immunotherapy response prediction by tumor aneuploidy score and fraction of copy number alterations
Authors: Chang Tiangen , Cao Yingying , Shulman Eldad , Schäffer Alejandro , Ben-David Uri , Ruppin Eytan 
Published: March 2023

Abstract
Identifying patients with low tumor mutation burden (TMB) that are likely to respond to cancer immunotherapy is an important, yet highly challenging clinical need. Using 3,139 patients across 17 different cancer types, we comprehensively studied the ability of two common copy number alteration (CNA) scores – the tumor aneuploidy score (AS) and the fraction of genome encompassed by copy number alterations (FGA) – to predict survival following immunotherapy in both pan-cancer and individual cancer types. We propose an elbow-point based method to optimize the cutoff used for calling CNAs. The optimized AS and FGA scores show significantly improved predictive performance compared to the arbitrary cutoffs reported in the literature. However, our data suggests that the use of AS and FGA for predicting immunotherapy response is currently limited to only a few cancer types. Therefore, larger sample sizes are needed to evaluate the clinical utility of these measures for patient stratification in other cancer types.
Multiple factors driving the acquisition efficiency of apple proliferation phytoplasma in Cacopsylla melanoneura
Authors: Corretto Erika , Trenti Massimiliano , Serbina Liliya Štarhová , Howie James Malcolm , Dittmer Jessica , Kerschbamer Christine , Candian Valentina , Tedeschi Rosemarie , Janik Katrin , Schuler Hannes 
Published: March 2023

Abstract

Phytoplasmas are bacterial pathogens located in the plant’s phloem that are responsible for several plant diseases and are mainly transmitted by phloem-sucking insects. Apple proliferation (AP) is an economically important disease caused by ‘CandidatusPhytoplasma mali’ which is transmitted by two psyllid species. While Cacopsylla picta is a confirmed vector in different regions, the vector efficiency of Cacopsylla melanoneura varies between different populations. This species is considered the main AP vector in Northwestern Italy but plays a minor role in Northeastern Italy and other European regions. To investigate whether the psyllid and/or the phytoplasma subtype drive the phytoplasma acquisition in C. melanoneura, we set-up a phytoplasma acquisition experiment using single mating couples including different psyllid populations and phytoplasma subtypes. All analyzed insect populations acquired phytoplasma, but with different efficiencies and concentrations. The main factors driving the acquisition were the phytoplasma subtype and its concentration in the leaves of the infected trees together with the psyllid family. The phytoplasma concentration in the psyllids was again influenced by the phytoplasma subtype, the psyllid family and the region of origin, whereas the phytoplasma concentration in the leaves and the psyllid haplotype defined with the cytochrome oxidase I gene had only a minor impact on the phytoplasma concentration. This is the first study evaluating the roles of both the psyllid haplotype and the phytoplasma subtype on the acquisition process shedding new light on the importance of C. melanoneura as AP vector.
Dietary Assessment of Type 2 Diabetic Patients using healthful plant-based diet score in the Eastern Province of Saudi Arabia
Authors: Alali Rudaynah A , Alateeq Suad A. , Almuhanna Afnan F , Eleq Abdulmohsen H Al , Albaker Waleed I , Habara Alawi , Alrubaish Fatima A , babuvatte Chitti , Loza Bao-Li , Al-Muhanna Fahad A , AlAli Amein K. 
Published: March 2023

Abstract
Background
Diabetes mellitus is a chronic disease characterized by a wide range of metabolic problems. The current study sought to assess nutritional habits of Saudi subjects with type 2 diabetes (T2D), in order to propose recommendation to improve these patients' dietary habits and delay possible disease complications.
Methods
Over a period of three years, (2017–2019) 577 patients with T2D attending the outpatient’s diabetic clinics at King Fahd Hospital of the University Al Khobar, Saudi Arabia were invited to participate in this study. Dietary intake data were collected by trained nurses using a pretested structured validated semi quantitative food frequency questionnaire. The dietary data were collected using 7-day dietary recall questionnaire. A modified score system that associates dietary habits with glycemic control and lipid profile was used.
Results
Overall, a high healthful plant-based diet score was associated with a significant (P = 0.018) reduction in TG level (difference, -3.78%; 95% CI, -0.65% to -6.81%) and a near statistically significant (P = 0.06) increase in HDL levels (difference 1.87%; 95% CI -0.06–3.84%) in T2D patients from the Eastern Province, Saudi Arabia. Additionally, in our patient cohort, the prevalence of coronary artery disease, stroke, peripheral artery disease, and chronic kidney disease in T2D patients was 11.3%, 6.2%, 3.3%, and 8.4%, respectively.
Conclusion
The present study showed that adherence to a healthful plant-based diet is associated with a favorable outcome in glycemic control and lipid profile in T2D patients in the Eastern Province of Saudi Arabia. Prior assessment of total diet quality may be beneficial when giving nutritional advice to patients with T2D with the objective of improving glycemic control and lipid profile.
Postoperative vision-related quality of life and functional vision outcomes with the Argus II Retinal Prosthesis
Authors: Bansal Jahnvi , Ghani Nimra , Naidu Abhishek , Chaudhary Khurram M. 
Published: March 2023

Abstract
Background
The Argus II Retinal Prosthesis (Second Sight Medical Products, California) was developed to enhance visual outcomes in patients with degenerative retinal diseases. The primary objective of this study was to describe changes in vision-related quality of life based on patient responses to the National Eye Institutes Visual Function Questionnaire (NEI VFQ-25) over a two-year postoperative period. The secondary objective was to assess a relationship between subjective NEI VFQ-25 scores and objective functional vision outcomes.
Methods
Five patients who were fitted with the Argus II Retinal Prosthesis due to profound retinal dystrophy were assessed in this study. The NEI VFQ-25 was given to patients prior to implantation, at month 12, and month 24 post-implantation. Functional vision data and images from each visit were extracted from the Argus II Retinal Prosthesis Post-Approval Study. Data analysis was completed on IBM SPSS.
Results
Between Month 0 and Month 24, there was a significant increase in VFQ score in the ‘Social Functioning’ subscale (p < 0.05), and there were other subscale trends towards increase over time. Spearman’s rank-order tests revealed significant positive correlations between various VFQ subscales and functional vision measures. ‘Dependency’ correlated with direction of motion (DOM) (rs = 0.745, p < 0.05) and with electrode array-retina gap distance (rs = 0.778, p < 0.05). ‘General Vision’ correlated with DOM (rs = 0.541, p < 0.05) and with electrode array-gap distance (rs = 0.581, p < 0.05). ‘Role Difficulties’ correlated with DOM (rs = 0.527, p < 0.05). No VFQ subscale correlated significantly with ‘square localization (SL).’
Conclusions
In patients with the Argus II Retinal Prosthesis, there may be change in vision-related quality of life over time, as postoperative changes in NEI-VFQ subscales were demonstrated. There may also be a relationship between vision-related quality of life and functional vision outcomes postoperatively, as exhibited by several significant correlations found between NEI-VFQ subscales and both direction of motion and electrode array-retina gap distance. It is essential to assess the role of patient-reported outcome measures and functional vision outcomes in helping clinicians guide long-term postoperative management and in helping innovators develop enhanced retinal implant technology.
Transgender Attitudes and Beliefs Scale-Greek (TABS-Gr) Version: Translation and Initial Evaluation of Psychometric Properties among Medical Students.
Authors: Voultsos Polychronis , Papana Angeliki , Alexandri Stella , Zymvragou Christina-Erato 
Published: March 2023

Abstract
Aim: Transgender people face significantly greater health inequities than cisgender people and experience discrimination in health care settings. The role of education in eliminating this discrimination and health disparities has been increasingly recognized by many medical schools. However, transgender-health content lacks or is sparse and considerably varying across different medical curricula in many countries. In Greece, there is limited research on medical students’ attitudes towards transgender people. This study aims to contribute to filling this knowledge gap.
Method: The study adopted a cross-sectional, comparative-descriptive research design. Purposive non-probability sampling was used to recruit the study participants (N=203). The study was designed to validate the Transgender Attitudes and Beliefs Scale (TABS)-Greek version scale and examine medical students’ attitudes towards transgender people. The data was collected between December and February 2023.
Results: The overall reliability of the TABS questionnaire is high (Cronbach's α = 0.961, Sig. from Hotelling’s T-Squared Test < 0.000). High Cronbach’s alpha values were estimated on the three subscales with α = 0.958 for Interpersonal Comfort, α = 0.906 for Gender Beliefs, and α = 0.952 for Human Value. Hotelling’s T-Squared Test confirmed that all items on the scale have the same mean (Sig. < 0.001 for all subgroups). Confirmatory factor analysis (CFA) demonstrated adequate fit. Its convergent and discriminant validity was validated based on the estimated correlations. The three-factor structure of Greek TABS Version has been confirmed. The mean total score was 155.95 (SD. = 30.63) indicating that medical students had a moderately positive attitude towards transgender people. Participants showed significantly less biased (more tolerant, positive) attitudes towards transgender people on the Interpersonal Comfort (IC) and Human Value (HV) subscales than on the Sex/Gender Beliefs (SGB) subscale. Overall psychometric findings provide support for further use of the TABS-Gr in Greek medical schools. A demographic comparison was conducted and demonstrated correlation between scores and socio-demographics, except for sexual orientation and place of origin. A statistically significant increase in total mean score was estimated for females compared to males.
Conclusion: This study provide support for further use of the TABS in Greece and can contribute to providing the evidence required to persuade universities to make changes to their curriculum to ensure that future physicians are in the position to provide high quality health care for transgender patients.