bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Efficacy of Bolus of Six Drugs Including Rehmannia as an Adjunct to Metformin in the Treatment of Senile Type-2 Diabetes Mellitus and its Influence on Insulin Resistance, Inflammatory Factors and Blood Glucose-related Indicators
Authors: Li Ning , Yao Yanru , An Erhui 
Published: July 2023

Objective: To investigate the clinical efficacy of Bolus of Six Drugs Including Rehmannia (Liuwei Dihuang pill) as an adjunct to metformin in the treatment of senile Type-2 diabetes mellitus and its influence on insulin resistance, inflammatory factors and blood glucose-related indexes.
Methods: This is a Retrospective study. Eighty senile Type-2 diabetes mellitus admitted to Baoding Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were enrolled and divided into two groups using the random number method. Patients in the control group were given oral metformin, while those in the observation group were treated with Bolus of six Drugs Including Rehmannia as an adjunct to metformin. The clinical efficacy, blood glucose-related indicators, insulin-related indicators, inflammatory factors-related indicators and adverse drug reactions were compared between the two groups.
Results: The overall response in the observation group was higher than that in the control group(P<0.05). After treatment, the levels of FPG, 2hPG and HbA1 being more significantly lower in the observation group than that in the control group(P<0.05). Moreover, the levels of FINS, HOMA-IR and HOMA-IS were all significantly improved in the observation group than that the control group (P<0.05). HOMA-β levels in the observation group were significantly higher than those in the control group (P<0.05). The levels of TNF-α, IL-6 and IL-8 in the observation group were significantly lower than those in the control group (P<0.05).
Conclusion: Bolus of six Drugs Including Rehmannia as an adjunct to metformin is a regimen with satisfactory safety profile for the treatment of senile Type-2 diabetes mellitus.
doi: https://doi.org/10.12669/pjms.39.5.7262
How to cite this: Li N, Yao Y, An E. Clinical Efficacy of Bolus of Six Drugs Including Rehmannia as an Adjunct to Metformin in the Treatment of Senile Type-2 Diabetes Mellitus and its Influence on Insulin Resistance, Inflammatory Factors and Blood Glucose-related Indicators. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7262
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A comparative study of early functional outcomes in undisplaced neck of femur fracture treated with partially threaded and fully threaded cannulated screw fixation in patients above 60 years age
Authors: Awais Muhammad Zarak , Salik Eman , Bokhari Syed Hassan Raza , Iqbal Muhammad Tahir 
Published: July 2023

Objective: To compare the partially threaded versus fully threaded cannulated screw fixation methods in stable neck of femur fracture in terms of early functional outcomes in patients of age 60 and above.
Methods: A randomized controlled trial was conducted at Orthopedic Unit-II, Mayo Hospital Lahore, Pakistan from July 2021 to July 2022. A total of 82 (41 in each group) patients of both genders, aged 60 or above were included. All patients had garden Type-I or II and were mobile before they fractured the femoral neck were included. In Group-A, cannulated screw fixation (cancellous screws 6 mm) was done using partially threaded screws while fully threaded screws (cancellous screws 6 mm) were used in Group-B. Patients were followed up at six weeks, three months and six months interval for “Radiographic Union Scale for Hip (RUSH)” and “Harris Hip score”.
Results: In a total of 82 (41 in each group) patients, 66 (80.5%) we male. At 6th week (p=0540) and 3rd month (p=0.653) postoperatively, no significant differences were seen between groups for Hip Harris score. However, at 6th month, functional outcome of Group-B patients was significantly better as compared to Group-A (p=0.038). Mean RUSH score in Group-A and in Group-B at 6th month postoperative was 25.45±2.73 and 30.52±2.39 (p<0.001).
Conclusion: Fully threaded cannulated screw fixation is better in treating undisplaced neck of femur fracture as compared to partially threaded cannulated screw fixation in terms of early functional outcomes among the age group of 60 years and above.
RCT Registration number: NCT05587660.
doi: https://doi.org/10.12669/pjms.39.5.7330
How to cite this: Awais MZ, Salik E, Bokhari SHR, Iqbal MT. A comparative study of early functional outcomes in undisplaced neck of femur fracture treated with partially threaded and fully threaded cannulated screw fixation in patients above 60 years age. Pak J Med Sci. 2023;39(5):---------. doi: https://doi.org/10.12669/pjms.39.5.7330
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Childhood life events of women enrolled in the Avon Longitudinal Study of Parents & Children (ALSPAC)
Authors: Gregory Steven , Iles-Caven Yasmin , Northstone Kate , Golding Jean 
Published: July 2023

At the time of planning ALSPAC there was accumulating evidence that abuse and other childhood traumas were related to psychiatric problems later in life. In addition, the age at which such trauma occurred was likely to be important in influencing its long-term impact. Detailed data was therefore collected from enrolled women on traumatic events occurring during their own childhoods, along with their age at the time. The questionnaire entitled ‘About Yourself’ was sent out to expectant women who had enrolled in the study, which included a page in the form of a grid (an events diary) with one row per year of childhood and columns for recording where she was living at the time, who was looking after her, and any traumatic events that occurred. These free-text responses were then coded, and any events were assigned a score indicating the level of trauma the event was likely to have caused on a scale of 1 (highly traumatic) to 6 (least traumatic). This paper describes the variety of text data collected and how it was coded. The ALSPAC study has a great deal of follow-up data collected on the original respondents, as well as on their parents and grandparents, partners, offspring and their grandchildren, providing huge potential for analyses on the antecedents and outcomes of adverse childhood events across multiple generations.
Recognizing Series-Parallel Matrices in Linear Time
Authors: Walter Matthias 
Published: July 2023

A series-parallel matrix is a binary matrix that can be obtained from an empty matrix by successively adjoining rows or columns that are copies of an existing row/column or have at most one one-entry. Equivalently, series-parallel matrices are representation matrices of graphic matroids of series-parallel graphs, which can be recognized in linear time. We propose an algorithm that, for an m-by-n matrix A with k nonzeros, determines in expected time whether A is series-parallel or returns a minimal non–series-parallel submatrix of A. We complement the developed algorithm by an efficient [Formula: see text]implementation and report about computational results. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms–Discrete. Funding: This work was supported by Nederlandse Organisatie voor Wetenschappelijk Onderzoek [Grant OCENW.M20.151]. Supplemental Material: The software that supports the findings of this study is available at the GitHub software repository ( https://github.com/discopt/cmr-series-parallel ).
10×10  Gbs directly modulated DFB laser array based on the REC technique
Authors: Yuan Wei , Zhao Jie , Wang Yaguang , Sun Zhenxing , Xiao Rulei , Chen Xiangfei 
Published: July 2023

We proposed and experimentally demonstrated a directly modulated distributed feedback (DFB) laser array with a transmission rate of 100 Gbps (10channels×10Gbps). The grating design is based on the reconstruction equivalent chirp (REC) technique, which enables precise control of the channel wavelength spacing to 100 GHz, as specified in the ITU-DWDM standard. DFB laser arrays incorporating the REC technique demonstrate excellent consistency performance, with a side-mode suppression ratio exceeding 48 dB, threshold current of approximately 20 mA, and modulation bandwidth of greater than 13 GHz at a bias current of 100 mA. We evaluated the laser’s performance by loading a 10 Gbps nonreturn-to-zero signal onto the laser using direct modulation and transmitting it over a 10 km single-mode fiber. Based on our experimental results, the proposed DFB laser array is promising to be utilized in the next generation of low-cost, 100 Gbps DWDM communication systems.
Intellectual conflicts of interest among cardiology and pulmonology clinical practice guidelines
Authors: Brems J. Henry , Wagner Taylor , Diamant Julia , Davis Andrea E. , Clayton Ellen Wright 
Published: July 2023

Background
Intellectual conflicts of interest (COI), like financial COI, may threaten the validity and trustworthiness of clinical practice guidelines (CPGs). However, comparatively little is known about intellectual COI in CPGs. This study sought to estimate the prevalence of intellectual COI and corresponding management strategies among cardiology and pulmonology CPGs.

Methods
We conducted a retrospective document review of CPGs published by cardiology or pulmonology professional societies from the United States, Canada, or Europe from 2018 to 2019 available via the Emergency Care Research Institute, Guidelines International Network, or Medscape databases. We assessed the percentage of authors with an intellectual COI, defined as i) authorship on a study reviewed by the CPG, ii) authorship of a prior editorial related to a CPG recommendation, or iii) authorship of a prior related CPG. Management strategies assessed included use of GRADE methodology, inclusion of a methodologist, and recusals due to intellectual COI. Outcomes were assessed overall and compared between cardiology and pulmonology CPGs.

Results
Among the 39 CPGs identified (14 cardiology, 25 pulmonology), there were a total of 737 authors, of whom 473 (64%) had at least one intellectual COI. Among all CPGs, a median of 67% (Interquartile Range 50%-76%) of authors had at least one intellectual COI, and COI was more prevalent among cardiology compared with pulmonology CPGs (84% vs 57%, p<0.001). There was variable use of management strategies among the CPGs, including use of GRADE methodology (64% of CPGs), inclusion of a methodologist (49%), and recusals due to intellectual COI (0%).

Conclusion
Intellectual conflicts of interest appear to be highly prevalent and under-reported among cardiology and pulmonology CPGs, which may threaten their validity. Greater attention to and improved management of intellectual COI by CPG-producing organizations is needed.
Identification of a partnership model between a university, for-profit, and not-for-profit organization to address health professions education and health inequality gaps through simulation-based education: A scoping review protocol
Authors: Siraj Samyah , Momand Beheshta , Brunton Ginny , Dubrowski Adam 
Published: July 2023

Introduction
Healthcare providers in rural and remote (R&R) areas of Canada do not have the same access to skills development and maintenance opportunities as those in urban areas. Simulation-based education (SBE) is an optimal technique to allow healthcare providers to develop and maintain skills. However, SBE is currently limited mainly to universities or hospital-based research laboratories in urban areas. The purpose of this scoping review is to identify a model, or components of a model, that outline how a university research laboratory can collaborate with a for profit and not-for-profit organization to facilitate the diffusion of SBE into R&R healthcare provider training.

Methods and analysis
This scoping review will be guided by the methodological framework introduced by Arksey and O’Malley in 2005 and the Methodology for Joanna Briggs Institute Scoping Reviews. Ovid MEDLINE, PsycINFO, Scopus, Web of Science, and CINAHL will be searched for relevant articles published between 2000 and 2022, in addition to grey literature databases and manual reference list searches. Articles describing a partnership model or framework between academic institutions and non-profit organizations with a simulation or technology component will be included. Titles and abstracts will be screened, followed by a full-text screening of articles. Two reviewers will participate in the screening and data extraction process for quality assurance. Data will be extracted, charted, and summarized descriptively to report key findings on potential partnership models.

Conclusion
This scoping review will provide an understanding on the extent of existing literature regarding the diffusion of simulators for healthcare provider training through a multi-institutional partnership. This scoping review will benefit R&R parts of Canada by identifying gaps in knowledge and determining a process to deliver simulators to train healthcare providers. Findings from this scoping review will be submitted for publication in a scientific journal.
Europa 2000
Authors: Siebeck Jürgen E. 
Published: July 2023

In den politischen Schlußfolgerungen des Dokuments “Europa 2000 – Perspektiven der künftigen Raumordnung der Gemeinschaft” schlägt die EG-Kommission im wesentlichen folgende Aktivitäten vor:– Maßnahmen zur Informationsverbesserung über Daten und Vorgänge mit Relevanz für Raumordnungsfragen auf europäischer Ebene;– die Einrichtung eines Ausschusses zur Raumentwicklung, um die gegenseitige Konsultation zu erleichtern;– die Sammlung sozioökonomischer Informationen über die Regionen;– die bessere Information der Planungsverantwortlichen über die Absichten ihrer Kollegen bezüglich größerer Infrastrukturmaßnahmen;– ein System zur Beobachtung und Aktualisierung raumrelevanter Informationen in Zusammenarbeit mit den Forschungsinstitutionen in den Mitgliedstaaten;– die weitere Entwicklung eines Geographischen Informationssystems (GIS);– spezifische Bereiche für Gemeinschaftsinterventionen■ in Grenzregionen (Binnengrenzen und externe Grenzen),■ zur Förderung von Kooperation zwischen Regionen und Städten,■ zur Schließung von fehlenden Verbindungsstücken in den transeuropäischen Netzen (vor allem zwischen der Peripherie und dem Zentrum),■ in innerstädtischen Problemfeldern (soziale Integration und Umwelt).Die für Regionalpolitik und Raumordnung zuständigen Minister haben auf ihrer informellen Sitzung am 18./19. November 1991 in Den Haag nicht nur das von der Kommission vorgelegte Dokument begrüßt, sondern auch den dort enthaltenen Vorschlägen weitgehend zugestimmt.
Oxygen excess ratio control of PEM fuel cell: fractional order modeling and fractional filter IMC-PID control
Authors: Siva Mullapudi , Puttapati Sampath Kumar , Araga Ramya , Sharma Shubhanshu , Patle Dipesh S. , Uday Bhaskar Babu Gara 
Published: July 2023

Abstract
Concerning global warming, an energy-efficient power source must produce low or no pollutant emissions and provide an unlimited fuel supply. Proton Exchange Membrane fuel cell (PEMFC) is an electrochemical device that transforms chemical energy into electrical energy. The performance and durability of PEM fuel cells are affected by voltage reversals and fuel starvation. Oxygen Excess Ratio (OER) is a crucial factor in controlling the fuel starvation of the PEMFC system. First, this work identified the PEMFC as an integer order and fractional-order first order plus time delay models using the predictor error method and Grunwald–Letnikov simulation method based on a trust-region-reflect algorithm, respectively. Fractional order models more accurately represented the PEM fuel cell system dynamics. Then, robust fractional filters cascaded with PID controllers based on the Internal Model Control scheme (IMC) are designed for identified integer and fractional order models to regulate the OER by compressor voltage manipulation. The genetic Algorithm (GA) optimization technique is used to find the optimal fractional filter tuning parameters. The proposed controller’s performance regarding Integral Absolute Error (IAE) and Total Variance (TV) is analyzed. Furthermore, the robustness of a perturbed plant and fragility with perturbed controllers are elucidated. The results show that a fractional filter cascaded with fractional order PID controller improves the performance compared to a fractional filter cascaded with integer order PID controllers.
Choosing opponents in skiing sprint elimination tournaments
Authors: Lunander Anders , Karlsson Niklas 
Published: July 2023

Abstract
In this study we analyse data from world cup cross-country skiing sprint elimination tournaments for men and women in 2015–2020. Instead of being assigned a quarterfinal according to a seeding scheme, prequalified athletes choose themselves in sequential order in which of the five quarterfinals to compete. Due to a time constraint on the day the competition is held, the recovery time between the elimination heats varies. This implies a clear advantage for the athlete to race in an early rather than in a late quarterfinal to maximize the probability of reaching the podium. The purpose of the paper is to analyse the athletes’ choices facing the trade-off between recovery time and expected degree of competition when choosing in which quarterfinal to compete. We find empirical support for the prediction that higher ranked athletes from the qualification round prefer to compete in early quarterfinals, despite facing expected harder competition. Nevertheless, our results also suggest that athletes underestimate the value of choosing an early quarterfinal. In addition, we propose a seeding scheme capturing the fundamental disparity across quarterfinals using the estimates from alogistic regression model.
Mechanical performance of date palm fiber-reinforced concrete modified with nano-activated carbon
Authors: Adamu Musa , Ibrahim Yasser E. , Ahmed Omar Shabbir , Drmosh Qasem A. 
Published: July 2023

Abstract
Date palm fiber (DPF) is an easily processed, low cost, and accessible natural fiber. It has mostly been used in composites for non-structural applications. For DPF to be utilized in cementitious composites for structural applications, ways to reduce its harmful effect on compressive strength must be devised. Therefore, in this study, nano-activated carbon (NAC), due to its filler effects, was used as an additive to produce the DPF-reinforced concrete (DPFRC). To produce the DPFRC, 0, 1, 2, and 3% by cement weight of DPF and NAC were added. The fresh properties, strength, and microstructure of the concrete were examined. The findings revealed that DPF decreased the consistency, density, and compressive strength. Additionally, it increases the porosity in the concrete microstructure. The addition of up to 1% NAC significantly improved the compressive, flexural, and split tensile strengths of the concrete, while it decreased the harmful impact of up to 2% DPF on the DPFRC’s strength. The split tensile and flexural strengths of the concrete were enhanced with the addition of up to 2% DPF without any NAC. The addition of up to 2% NAC densified the DPFRC’s microstructure by refining and filling the pores generated by the DPF. The multivariable statistical models developed to estimate the mechanical properties of the DPFRC containing DPF and NAC were very significant with a very high degree of precision.
Factors determining cassava farmers’ accessibility to loan sources: Evidence from Lampung, Indonesia
Authors: Suryani Ani , Masyhuri  , Rahayu Waluyati Lestari 
Published: July 2023

Abstract
Credit accessibility is crucial for sustainable agricultural development. However, the difficulty in accessing credit has caused farmers to take many considerations when taking a loan. This research aims to determine the factors determining access and credit sources for cassava farmers in Lampung Province, Indonesia. Central Lampung was chosen as the research location because it had a total cassava production share of 36%. This study used Isaac’s and Michael’s formulae to determine the total samples. The data were collected by interviewing 263 respondents. Of 263 farmers, only 109 (41.4%) had access to loans. Data were analysed using the Multinomial Logit Regression Model to examine the factors determining access and credit sources for cassava farmers. Marginal effect analysis was also used to determine the probability of changes in independent variables. Regression results showed that the type of credit sources chosen by the farmers was determined by age, income, agribusiness experience, land size, education, organisation membership, and credit experience (R
2 = 89.1%). Partially, age, income, land size, education, credit experience, and business experience significantly influence the funding source. The results indicate that age, agribusiness experience, and land size are the main factors in choosing the types of credit. Land size has the biggest positive influence on farmers’ access to formal banks (11.49%).
Gut microbiota regulates blood‐cerebrospinal fluid barrier function and Aβ pathology
Authors: Xie Junhua , Bruggeman Arnout , De Nolf Clint , Vandendriessche Charysse , Van Imschoot Griet , Van Wonterghem Elien , Vereecke Lars , Vandenbroucke Roosmarijn E 
Published: July 2023

AbstractAccumulating evidence indicates that gut microbiota dysbiosis is associated with increased blood–brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) pathogenesis. In contrast, the influence of gut microbiota on the blood‐cerebrospinal fluid (CSF) barrier has not yet been studied. Here, we report that mice lacking gut microbiota display increased blood‐CSF barrier permeability associated with disorganized tight junctions (TJs), which can be rescued by recolonization with gut microbiota or supplementation with short‐chain fatty acids (SCFAs). Our data reveal that gut microbiota is important not only for the establishment but also for the maintenance of a tight barrier. Also, we report that the vagus nerve plays an important role in this process and that SCFAs can independently tighten the barrier. Administration of SCFAs in AppNL‐G‐F mice improved the subcellular localization of TJs at the blood‐CSF barrier, reduced the β‐amyloid (Aβ) burden, and affected microglial phenotype. Altogether, our results suggest that modulating the microbiota and administering SCFAs might have therapeutic potential in AD via blood‐CSF barrier tightening and maintaining microglial activity and Aβ clearance.