bluuebunny/crossref_metadata_2025_split huggingface dataset:
From gaming to reality: effectiveness of skills transfer from competitive sandbox gaming environment to near and far contexts
Authors: Zhong Yuchun , Fryer Luke Kutszik , Zheng Shiyue , Shum Alex , Chu Samuel Kai Wah 
Published: January 2025

AbstractEsports or competitive video gaming has been increasingly utilized to enhance essential twenty-first century skills. However, there is limited evidence on the extent to which the skills acquired from a gaming environment can be transferred to other settings. This study employed an experimental design to investigate the effectiveness of a competitive sandbox game environment in enabling the transfer of the 4Cs skills to both near and far tasks, in contrast with a non-game environment. A cohort of 110 students from a university were randomly allocated to both conditions for the 4Cs skills training. The skills transferability was measured through self-reports, observations, and interviews. The findings indicated no significant differences in the transfer of creativity, critical thinking, and communication skills in near and far settings following both training environments. Interestingly, a competitive gaming environment significantly facilitated the transfer of collaboration skills to near tasks evidenced by performance-based assessments. Moreover, although the hypotheses 1c and 3c were not statistically supported, the small to medium effect size suggests that there were practical differences between the groups in self-reported collaboration skills in near and far tasks. Additionally, analysis of individual interviews with 41 participants indicated that the successful transference was attributed to an array of scaffolds (i.e., mentorship, collaborative problem-solving environment, autonomy, and guided checklists) while the failure to detect positive effects was explained by various constraints (i.e., unfamiliarity with game rules, limited time, lack of practice, and established cognitive patterns). These findings add new insights into the literature on game-based learning and transfer of learning and inform researchers to further investigate the longitudinal effect of skills transfer and retention in both academic and professional spheres.
Transcatheter closure of multiple ventricular septal ruptures after acute myocardial infarction: a case report highlighting the role of 3D transthoracic echocardiography
Authors: Ardini Tengku Winda , Sarastri Yuke , Purba Joy Wulansari , Taufik Yasdika Imam , Asriri Suci , Nasution Ali Nafiah 
Published: January 2025

Abstract
Background
Post-infarct ventricular septal rupture (PI-VSR) is a rare complication of acute myocardial infarction (AMI) but has very serious implications. Managing PI-VSR using transcatheter closure (TCC) presents varying challenges depending on the patient’s condition. The aim of this study is to present a highly challenging case of multiple VSRs as a complication of AMI.
Case presentation: A 59-year-old male was admitted with symptoms of shortness of breath, dyspnea on exertion, orthopnea, and swelling of the lower extremities. He had typical chest pain related to infarction 2 weeks before his admission. On electrocardiogram (ECG) examination, evidence of an old myocardial infarction in the infero-antero-lateral regions was seen. Echocardiography showed mild mitral and tricuspid regularities. The left ventricular (LV) systolic function was mildly compromised, with a global ejection fraction of 44%. There was also a left-to-right VSR shunt in the apical region of the LV. Multiple defects as outlined by 3D transthoracic echocardiography (TTE)—the largest measuring 17 mm. Given the high risks of open-heart surgery, a percutaneous closure of the VSR was carried out using a 21 mm atrial septal defect (ASD) occluder. The device was satisfactorily placed, and there was an improvement in the clinical condition of the patient. He was discharged after his 8-day stay in the hospital.

Conclusion
Our study emphasizes that echocardiography with 3D imaging provides a more detailed view of the size and shape of the rupture and serves as a valuable modality for guiding the percutaneous transcatheter VSR closure procedure.
Attitudes towards mental health professionals in social media: infodemiology study
Authors: Battle Harriet , Álvarez-Mon Miguel Ángel , Lara-Abelenda Francisco J. , Perez-Araluce Rafael , Pinto da Costa Mariana 
Published: January 2025

Background
Negative perceptions of mental health professionals can deter individuals from seeking mental healthcare. Given the high burden of mental health globally, it is essential to understand attitudes towards mental health professionals. Social media platforms like Twitter/X provide valuable insights into the views of the general population.

Aims
This study aimed to use social media to investigate the (a) public perceptions (positive or negative) of mental health professionals, (b) changes in these perceptions over time and (c) engagement levels with tweets about mental health professionals over time.

Method
We collected all tweets posted in English between 2007 and 2023, containing key terms such as ‘mental health’, ‘psychology’, ‘psychologist’, ‘psychiatry’, ‘psychiatrist’, ‘neurology’ and ‘neurologist’. A total of 1500 tweets were manually classified into categories, which were used in conjunction with semi-supervised machine learning to categorise a large data-set.

Results
For most key terms, there was a higher frequency of positive perceptions compared with negative, with this trend improving over time. However, tweets containing ‘psychiatrist’ exhibited a higher proportion of negative perceptions (n = 4872, 39.52% negative v. n = 1972, 15.99% positive before 2020). After 2020, the gap narrowed, yet negative perceptions continued to dominate (n = 5505, 36.10% negative v. n = 3472, 22.77% positive).

Conclusions
Overall, positive perceptions of mental health and mental health professionals increased over time. However, ‘psychiatrist’ had a consistently higher proportion of negative perceptions. This study underscores the need to improve public perception of psychiatrists, and demonstrates the potential of using Twitter/X to better understand public attitudes and reduce stigma associated with accessing mental health services.
Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice
Authors: Poelman Renée , Le May Marie V , Schéle Erik , Stoltenborg Iris , Dickson Suzanne L 
Published: January 2025

Abstract
Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor (GHSR), promotes food intake and other feeding behaviors, and stimulates growth hormone (GH) release from the pituitary. Growth hormone secretagogues (GHS), such as GHRP-6 and MK-0677, are synthetic GHSR ligands that activate orexigenic neuropeptide Y neurons that coexpress agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus when administered systemically. Systemic GHRP-6 also stimulates GH release in humans and rats. Thus, GHS and ghrelin have therapeutic relevance in patients who could benefit from its orexigenic and/or GH-releasing effects. This study examined whether intranasal delivery of ghrelin, GHRP-6, or MK-0677 engages the brain ghrelin signaling system.
Effective compounds and doses were selected based on increased food intake after intranasal application in mice. Only GHRP-6 (5 mg/kg) increased food intake without adverse effects, prompting detailed analysis of meal patterns, neuronal activation in the arcuate nucleus (via Fos mapping) and neurochemical identification of c-fos messenger RNA (mRNA)-expressing neurons using RNAscope. We also assessed the effect of intranasal GHRP-6 on serum GH levels.
Intranasal GHRP-6 increased food intake by increasing meal frequency and size. Fos expression in the arcuate nucleus was higher in GHRP-6–treated mice than in saline controls. When examining the neurochemical identity of c-fos-mRNA–expressing neurons, we found coexpression with 63.5 ± 1.9% Ghsr mRNA, 79 ± 6.8% Agrp mRNA, and 11.4 ± 2.5% Ghrh mRNA, demonstrating GHRP-6's ability to engage arcuate nucleus neurons involved in food intake and GH release. Additionally, intranasal GHRP-6 elevated GH serum levels. These findings suggest that intranasal GHRP-6, but not ghrelin or MK-0677, can engage the brain ghrelin signaling system.
Medical Therapy Alone for Ommaya Reservoir–Associated Bacterial Meningitis: When It Works and When It Fails
Authors: Tuohy Kyle , Dowd Richard , Ali Ayesha , Badani Aarav , Sichinga Krishana , Zacharia Brad E. , Mansouri Alireza , Aregawi Dawit , Glantz Michael 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Administration of intraventricular chemotherapy through Ommaya reservoir is indicated for certain forms of leptomeningeal disease. However, ventricular reservoirs carry a substantial risk of infection. The conventional approach to managing reservoir-associated infections involves removal of the reservoir and systemic antibiotic therapy, but this strategy necessitates additional procedures to remove and subsequently replace the device. We evaluated the success rate of standardized, multimodal medical therapy alone in treating reservoir-associated meningitis and factors associated with the need for device removal.

METHODS:
We used the International Neoplastic Meningitis Academic Registry Consortium database to identify patients at our institution with reservoir-associated bacterial meningitis. A standardized antibiotic regimen of oral rifampin, intraventricular vancomycin, and another intravenous antibiotic based on the infecting organism was used to treat infections for 10 to 14 days. We evaluated the rate of infection clearance and factors associated with success of therapy without reservoir removal.

RESULTS:
Forty-eight infections in 33 patients (5.79% of all patients) were identified. Before infection, reservoirs were accessed a median of 6 (1-14) times. Infections were eradicated without reservoir removal in 39 of 48 patients (81.3%). Cerebrospinal fluid (CSF) leak/local wound infection was the only factor associated with the need for reservoir removal (odds ratio = 18.3 [3.68-141], P < .001) on multivariate analysis, and 98.0% of patients without this characteristic were cured with medical therapy alone. Other characteristics such as age, myelosuppression, tumor histology, number of reservoir accesses, concurrent systemic chemotherapy, or infecting organism were not predictive of reservoir removal. Random forest and gradient boost machine learning models further confirmed CSF leak/local wound infection to be the most important predictor of removal.

CONCLUSION:
Most patients who develop a reservoir-associated infection can be successfully treated with a standardized antibiotic regimen alone, without additional surgery for reservoir removal and subsequent replacement. However, CSF leak/reservoir site infection is strongly associated with failure of medical therapy and warrants early device removal.
Impact of Revascularization Timing on Clinical Outcomes of Symptomatic Moyamoya Disease: A Systematic Review and Multivariate Analysis
Authors: Edelbach Brandon , Lopez-Gonzalez Miguel Angel 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Despite a substantial body of literature describing the efficacy of revascularization compared with conventional management of moyamoya disease (MMD), the impact of the timing of revascularization relative to stroke onset remains inadequately characterized. The aim of this review was to synthesize existing research to guide clinicians in the optimal timing of revascularization in symptomatic MMD.

METHODS:
A comprehensive literature review was performed to identify studies reporting on timing of revascularization. Studies were divided into revascularization within 3 months of stroke, between 3 and 6 months of stroke, or >6 months from stroke event.

RESULTS:
A total of 3049 cases and 3151 treated cerebral hemispheres were included. There were 91 individuals (2.98%) in the 3 months to intervention cohort, 152 (4.92%) individuals in the 3 to 6 months to the intervention cohort, and 2806 (92.0%) individuals in the >6 months to the intervention cohort. The average follow-up time was 43.8 ± 35.19 months. Clinical improvement was reported in 83.4% of cases overall. The 3-to-6-month poststroke preoperative interval has the highest frequency of clinical improvement (90.2%), followed by the >6-month preoperative interval (83.4%). The preoperative interval of <3 months had the lowest frequency of clinical improvement (76.5%). Comparison of average treatment effect in the treated demonstrated reduced frequency of improved clinical outcome (Mean difference: −22.6, SE: 9.15, P = .013) and increased frequency of worse clinical outcome (Mean difference: 20.1, SE: 7.38, P = .006) in the <3 months cohort. The >6 months cohort was found to be associated with a reduced frequency of worse clinical outcome (Mean difference −1.81, SE: 0.349, P = .001).

CONCLUSION:
The findings of this meta-analysis suggest that, in cases where it is clinically feasible to delay revascularization following an acute neurological event in patients with MMD, postponing intervention is warranted.
FGFR2 directs inhibition of WNT signaling to regulate anterior fontanelle closure during skull development
Authors: Bobzin Lauren , Nickle Audrey , Ko Sebastian , Ince Michaela , Huang Aaron , Bhojwani Arshia , Roberts Ryan , Merrill Amy E. 
Published: January 2025

ABSTRACT
The calvarial bones of the infant skull are linked by transient fibrous joints known as sutures and fontanelles, which are essential for skull compression during birth and expansion during postnatal brain growth. Genetic conditions caused by pathogenic variants in FGFR2, such as Apert, Pfeiffer, and Crouzon syndromes, result in calvarial deformities due to premature suture fusion and a persistently open anterior fontanelle (AF). In this study, we investigated how Fgfr2 regulates AF closure by leveraging mouse genetics and single-cell transcriptomics. We find that AF cells, marked by the tendon/ligament factor SCX, are spatially organized into ecto- and endocranial domains that selectively differentiate into ligament, bone, and cartilage to form the posterior frontal suture. We show that AF cell differentiation is non-autonomously regulated by FGFR2 signaling in osteogenic front cells of the frontal bones, which regulate WNT signaling in neighboring AF cells by expressing the secreted WNT inhibitor Wif1. Upon loss of Fgfr2, Wif1 expression is downregulated, and AF cells fail to form the posterior frontal suture. This study identifies an FGF-WNT signaling circuit that that directs suture formation within the AF during postnatal development.
Oral and intestinal manifestations of giant cell arteritis
Authors: Pernet Mathieu , Moi Laura , Serra Fulvia , Garin Nicolas 
Published: January 2025

Background: Giant cell arteritis (GCA) is the most common primary vasculitis in individuals over 50 years of age. GCA typically affects large- and medium-sized arteries and is classically associated with cranial manifestations of ischaemia, such as headaches (notably in the temporal region), jaw claudication and visual symptoms that can lead to blindness. Extracranial symptoms are less frequently reported and are related to involvement of the thoracic and abdominal aorta and its main branches. Classic diagnostic tools (such as temporal artery ultrasonography and temporal artery biopsy) can be negative in extracranial GCA. Case description: We report a difficult diagnosis of GCA in a 75-year-old woman who developed painful tongue ulcers that responded to prednisone treatment. However, a comprehensive diagnostic work-up did not lead to a certain diagnosis of GCA and corticosteroids were stopped after one month. A few months later, the patient suffered from mechanical ileus secondary to ischaemic stenosis of the small bowel. Pathological examination of the small bowel resection, and a second FDG-PET/CT, led to the diagnosis of extracranial GCA. Conclusions: We present a case of CGA which sequentially affected cranial and extracranial arteries and illustrate pitfalls in the diagnosis of this polymorph condition.
Ascensão E Queda Da Unasul: Ideologia, Política Externa E Integração Regional A Partir Dos Casos Da Argentina E Brasil | Rise And Fall Of Unasur: Ideology, Foreign Policy And Regional Integration Based On The Cases Of Argentina And Brazil
Authors: Corrêa Tammy Eduarda 
Published: January 2025

RESUMO
Este artigo tem como objetivo analisar e identificar sob uma perspectiva histórico-comparada o que explica a ascensão e declínio da Unasul. O estudo examina o período de 2008 a 2022 e caracteriza-o através das particularidades políticas e ideológicas na América do Sul, especialmente no que tange à consonância de políticas externas, abrangidas pela alternância dos fenômenos da onda rosa e da onda conservadora. A principal hipótese é que a convergência e a divergência ideológica influenciam o contexto sul-americano nas tendências e nos tipos de cooperação regional. Duas nações determinantes para a análise são a Argentina e o Brasil que, através das transições de governo e ideologias no poder, influenciam em mudanças quanto ao tipo de interação e integração regional através de suas políticas externas. Em consequência, é percebido um processo de esvaziamento da Unasul sob críticas de viés político-ideológico.
Palavras-chave: Unasul; Política Externa; Ideologia.

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ABSTRACT
This article aims to analyze and identify, through a historical-comparative perspective, what explains the rise and decline of Unasur. The study examines the period from 2008 to 2022 and characterizes it through the political and ideological particularities of South America, especially regarding the consonance of foreign policies, encompassed by the alternation of the pink tide and conservative wave phenomena. The main hypothesis is that ideological convergence and divergence influence the South American context in terms of trends and types of regional cooperation. Two decisive nations for the analysis are Argentina and Brazil, which, through government transitions and ideologies in power, influence changes in the type of interaction and regional integration through their foreign policies. As a result, a process of emptying of Unasur is perceived under criticism of political-ideological bias.
Keywords: Unasur; Foreign Policy; Ideology.
Globalização, Regionalismo E Espacialização Nas Relações Internacionais | Globalization, Regionalism, And Spatialization In Contemporary International Relations
Authors: Lattanzi Eduarda , Tostes Ana Paula 
Published: January 2025

RESUMO
O artigo visa traçar uma história transversal sobre o desenvolvimento do regionalismo, desde uma abordagem conceitual e analítica institucionalista, ao priorizar o papel de organizações internacionais e regionais no processo de normatização internacional. Partimos do pressuposto de que processos de regionalização se ajustaram a demandas da política e da economia no século XXI, de forma a provocarem novas abordagens teóricas sobre regionalismos comparados e inter-regionalismo (Börzel e Risse, 2016; Acharya, 2009; Hänggi, 2006; Robles, 2008, por exemplo). Nesse contexto, entretanto, o papel dos espaços regionais institucionalizados passa a revelar novas ambições de exportação de projetos regionais consolidados (Middell e Marung, 2019) para outros espaços internacionais. O artigo visa contribuir para o debate sobre o papel de organizações regionais e de que forma o tema do regionalismo passa a revelar novas ambições de exportação de projetos regionais consolidados (Middell e Marung, 2019) para outros espaços internacionais.
Palavras-chave: Organizações Regionais; Cooperação Internacional; Instituições Internacionais.

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ABSTRACT
This article aims to outline a cross-sectional history of the development of regionalism, using a conceptual and institutionalist analytical approach that prioritizes the role of international and regional organizations in the process of international norm-setting. We start from the assumption that processes of regionalization have adapted to the demands of politics and economics in the 21st century, provoking new theoretical approaches to comparative regionalisms and inter-regionalism (Börzel and Risse, 2016; Acharya, 2009; Hänggi, 2006; Robles, 2008, for example). In this context, however, the role of institutionalized regional spaces reveals new ambitions for exporting established regional projects (Middell and Marung, 2019) to other international spaces. This article aims to contribute to the debate on the role of regional organizations and how the theme of regionalism unveils new ambitions for exporting established regional projects (Middell and Marung, 2019) to other international spaces.
Keywords: Regional Organizations, International Cooperation; International Institutions.
INSPIRAÇÃO NOS ENCONTROU TRABALHANDO
Authors: Barbosa Edja Souza , De Albuquerque Tereza Cristina Cavalcanti 
Published: January 2025

A preparação de professores e professoras para o ensino de Arte nos Anos Iniciais ainda é fragilizada. Refletir sobre esta formação possibilita aos futuros professores/as ressignificar esta jornada educativa, ao mesmo tempo que se projeta que uma nova maneira de ensinar Arte é possível e necessária. Há um aumento da utilização da narrativa, tanto como método de pesquisa quanto como oportunidade formativa, principalmente no campo da formação de professores/as. Este artigo tem por objetivo analisar as narrativas produzidas por estudantes de Pedagogia de uma universidade pública federal do estado de Alagoas sobre suas experiências na disciplina Saberes e Metodologias para o Ensino de Arte. Foi utilizada a metodologia da Pesquisa Narrativa e como aporte teórico autores como Benjamin (1994), Oliveira (2017), Ventura (2020), Barbosa (2012), Ferraz e Fussari (2010), Iavelberg (2003), dentre outros. Como resultado, observou-se que o ato de narrar, tendo como foco a autoavaliação, constitui oportunidade de aprendizado.

A INSPIRAÇÃO NOS ENCONTROU TRABALHANDO: NARRATIVAS SOBRE A FORMAÇÃO DOCENTE PARA O ENSINO DE ARTE NOS ANOS INICIAIS
A RELEVÂNCIA DA PRÁTICA DA LEITURA NO PROCESSO DE ALFABETIZAÇÃO
Authors: Alonso Ana Claudia Ortega , Costa Erika Karla Barros da , OLIVEIRA ARÃO DAVI , Oliveira Vanessa Janaína viana de 
Published: January 2025

A alfabetização e a leitura são processos que são desenvolvidos de forma indissociável na prática pedagógica. No bojo desse objeto, visou-se responder se há efetividade da prática da leitura como elemento que auxilia o processo de alfabetização? Por isso, traçamos como objetivo: discutir como a prática da leitura pode contribuir no desenvolvimento do processo de alfabetização. Desenvolveu-se uma pesquisa bibliográfica e documental, com abordagem qualitativa, na qual utilizou-se pressupostos de Soares (2011, 2018, 2020); Ferreiro e Teberosky (1985); e Freire (1982, 1987, 1994 ,1996) para analisar o dados coletados. Os resultados indicam que a leitura no processo de alfabetização torna-se uma ferramenta indispensável, pois colabora na formação do leitor, inserindo-o na sociedade letrada de forma adequada. Para tanto, é necessário que possibilitem condições favoráveis para a prática da leitura, despertando leitores críticos. A prática de leitura precisa ser estimulada para que possa ser introduzida na experiência da criança como uma atividade que promova mudança de hábito e comportamento.