bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent progress in apoptosis triggering facilitated by HeLa Studies
Authors: Constantin Maria Teodora , Beleaua Marius Alexandru 
Published: June 2023

Abstract

Objective: Cancer is a leading cause of death globally, prompting numerous efforts to find effective treatments. HeLa cells, derived from Henrietta Lacks’ cancerous squamous cells, have played a crucial role in cancer research due to their origin, resistance, and rapid growth. They are particularly useful for studying ways of cellular death triggering, or apoptosis, without an immune response. Thus, the objective of this paper was to review the latest publications on the subject of HeLa apoptosis so that a brief view to be available on the otherwise so extended subject.

Methodology: To provide a concise review of the extensive research on this topic, a search was conducted using the phrase “HeLa cells apoptosis triggering” on PubMed. The articles that were published in English, in the last 6 years, presenting results sustained by valid morphological and chemical apoptotic changes present in cells, were selected and reviewed. A comprehensive table presenting the apoptotic mechanism exerted by each substance was made to assure a concise presentation of the results.

Results: The reviewed studies have shown that many natural substances exhibit pro-apoptotic activity on malignant cells and can be used as chemotherapeutic agents. Some synthetic molecules were showed to have good results too. Important facts about these substances, their intervention site and metabolic modifications are presented in a concise form. The use of nano-carriers for targeted delivery was shown to increase their specificity towards cancerous cells.

Conclusions: HeLa cells were a groundbreaking discovery that revolutionized scientific research. Although there is ongoing research towards cancer cures using HeLa cells, there are still many trials and considerations that need to be addressed. With the countless existing HeLa cell lines, the scientific possibilities for research are endless.
Medicinal plants: A promising source of anti-diabetic agents in sub-Sahara Africa
Authors: Aloke Chinyere , Egwu Chinedu Ogbonnia , Adelusi Oluwasola Abayomi , Chinaka Nnamdi , Kanu Shedrach Chidiebere , Ogbodo Peace Nzubuchukwu , Akumadu Blessing Oluebube , Achilonu Ikechukwu 
Published: June 2023

Abstract
The rising burden of Diabetes mellitus (DM) globally and particularly in sub-Sahara Africa calls for alternative treatment solutions. This is because the currently available drugs for its management are limited due to undesirable adverse effects and high cost. Thus, this review explores diabetes and summarizes its treatment options, focusing mainly on medicinal plants therapy. Information on twenty-five selected medicinal plants from sub-Sahara Africa having hypoglycemic and anti-diabetic potentials was obtained via electronic search of major databases, such as Pubmed/Medline, Scopus, Google Scholar and web of science. Predominant bioactive compounds found in these plants include tannins, carpaine, terpenoids, hexadecenoic acid, luteolin, saponins, glycosides, rutin, quercetin, vindoline and kaempferol. Robust evidence indicates that these medicinal plants and their bioactive components exert their antidiabetic potentials via different mechanisms, including: regeneration of pancreatic β-cell and insulin secretion; inhibition of α-amylase, inhibition of intestinal glucose absorption and liver glucose production; antioxidative stress; limitation of glycogen degradation and gluconeogenesis; anti-inflammatory, immunoregulatory. DM imposes a tremendous burden in the region, and its prevalence is not abating; thus the rich flora of the region with known hypoglycemic and antidiabetic efficacy could be explored as a complementary therapy in its management.
Healthcare professional’s knowledge and awareness of the medication error reporting systems in the Kuwaiti hospitals
Authors: Saada Mohammad 
Published: June 2023

Abstract

Objective. A survey was conducted to explore healthcare professional’s (HCPs) knowledge and attitude towards medication errors reporting processes and systems used in their local hospitals.

Methods. There were 696 respondents and the observational survey showed the diverse perspectives of HCPs from diverse professions (doctors, pharmacists and nurses) who are at different stages in their career. The survey results highlighted the deficiencies in the medication safety management process, including the follow-up on witnessed or discovered medication errors, the effectiveness of the used reporting systems for medication errors, the standardisation of electronic prescribing software, and the training of HCPs at the six hospitals on medication safety.

Key finding. Only 46% of the surveyed stated that their hospital had a mechanism in place for reporting medication errors and 60.7% of the participants agreed that they would submit reports provided the system is not used for performance management and only those need to know will be able to identify their name. Regarding prescription writing, 51% of surveyed HCPs said they utilise electronic prescribing software; however, the overall usage rate of electronic prescribing systems was 49%, with handwritten prescriptions remaining the option used in the majority of the time. In terms of HCP training, 20% of the survey respondents said they did not receive any instruction or direction in the hospitals on pharmacovigilance and patient safety.

Conclusions. The Kuwaiti MoH should build a national electronic incident reporting system and establish standardised rules and protocols for incident reporting that is to be anonymous and of compulsory use by all government and private hospitals.
The role of the L-arginine-NO-cGMP pathway in the development of tolerance to mephedrone-induced hyperlocomotion in mice
Authors: Bielecka-Papierz Gabriela , Poleszak Ewa , Szopa Aleksandra , Listos Joanna , Orzelska-Gorka Jolanta , Jakobczuk Małgorzata , Baluk Kamila , Talarek Sylwia , Serefko Anna 
Published: June 2023

Abstract
The tendency of a psychostimulant to increase locomotion in rodents is considered to be associated with its addictive properties. Mephedrone, one of the most popular psychoactive substances used recreationally, is known to enhance locomotor activity in mice, but little is known about the potential development of tolerance to its central effects. In the present study, we decided to evaluate the possible involvement of the L-arginine-NO-cGMP pathway in the development of tolerance to mephedrone-induced hyperlocomotion. Experiments were performed on adult male Albino Swiss mice, and the locomotor activity was measured automatically. Our work indicated that a 5-day administration of L-NAME (25 or 50 mg/kg/day), methylene blue (5 or 10 mg/kg/day), and L-arginine hydrochloride (i.e., 250 mg/kg/day) prevented the development of tolerance to mephedrone-induced (5 mg/kg/day) hyperlocomotion, whereas treatment with L-arginine hydrochloride at a dose of 125 mg/kg/day potentiated the development of tolerance to this central effect of mephedrone. Summarizing, our data revealed that the L-arginine-NO-cGMP pathway contributes to the development of tolerance to mephedrone’s central effects since inhibition of this signalling via blocking of NOS or NO-stimulated sGC prevented the development of tolerance to mephedrone-induced hyperlocomotion. As for cGMP-regulated phosphodiesterases, most probably they are not involved in these mechanisms.
Characterization and Evaluation of Vermicomposting Materials
Authors: Filipović Adrijana , Mandić Ana , Hadžiabulić Alisa , Johanis Hana , Stipanović Antonio , Brekalo Helena 
Published: June 2023

Abstract
The agricultural sector and growing food production needs rely on chemical fertilizers. This initially had positive effects on production, but over the last decade, the negative impacts of overuse have resulted in low crop productivity, increased pest and disease infestation, soil degradation, and consequent adverse effects on environmental parameters. As one of the possibilities in organic farming, we found vermicomposting as the most sustainable practice. For the assembly of vermicomposting, mature cattle manure was utilized in three different combinations with organic material and earthworm inoculations (the household waste, the grass clippings, and mixture). The experiment was set up by random block design in three replications. Analyses of qualitative parameters of the final product showed a pH reaction from neutral to slightly alkaline. The nitrogen compound varied between 2.7% and 2.9% and the organic carbon varied between 45.59% and 47.41%, showing a C/N ratio of 16.7‒16.67. The potassium content varied between 1.1% and 1.2% K2O, and the phosphorus content varied from 0.3% to 0.5%. The experiment gave quite good results of vermicomposting of household waste with manure, showing a neutral pH reaction, optimal content of ash and carbon with almost similar and good NPK contents and increased C/N ratio of 16.7, and with satisfying levels of trace elements and the heavy metal content under the limits. This combination of household waste and manure also showed best characterization of humic and fulvic acids in vermicompost, ranging from 1505 to 1778 cm−1 and from 729 to 998 cm−1, respectively. These results indicate that vermicomposting can increase the quality of the final product.
Investigation of Flora, Soil, and Biodiversity of Ecosystems in Arid Eastern Moroccan Rangelands
Authors: Hachmi Azeddine , Zbiri Asmae , El Alaoui-Faris Fatima Ezzahrae 
Published: June 2023

Abstract
Recently, pastoral ecosystem has been strongly studied by naturalists. However, phytoecological research must focus on species richness and enhance these ecosystems. The main objective of this research is to prove that the Moroccan pastoral ecosystem is very rich in terms of soil biodiversity and plant formations. In such areas, some pastoral plants maintain the physicochemical characteristics of soil. The field experiment was based on Braun-Blanquet sampling method with 90 surveys. The vegetation surveys carried out during the spring of the 2014–2018 period showed that there were 30 families, 23 orders, and 99 plant species (47 perennial species and 52 annual or biennial species). Of the 99 species inventoried, 14 species are very rare (RR) (14% of the total flora), six are rare (R), five are suspected rare (R?), three species are extinct or of doubtful presence (??), two are vulnerable (or seem to be), in decline, and could become rare in the short term (V), and one is a suspected very rare taxon (RR?). Investigation of life forms based on Raunkiaer method showed that there were various plants in different life forms. Among them, terophytes (47%) and 2% phanerophytes had the highest and the lowest plant species, respectively. This work led us to discover six species (Atractylis cancellata, Carduus pycnocephalus, Scorzonera angustifolia, Telephium sphaerospermum, Teucrium luteum, and Androsace maxima) and five types of rangeland in eastern Morocco. Chorology results showed a high proportion of Mediterranean biogeographic species in the study area, with a percentage of 35%. North African species followed the Mediterranean, with 14%. Euro-Mediterranean species constituted the major flora in the arid regions and played a significant role in the Mediterranean rangelands with 8%. The percentage of North African and Eurasian species was 6%, followed by North African and Asian species forming 4% of the total species. Eurasian, Paleo temperate, and Mediterranean Asian species had the same percentage (3%). The remains represented a low percentage, but contributed to the diversity and the richness of phytogeographic potential in the rangelands of eastern Morocco.
Effect of Seed Processing by Flying Foxes and the Patas Monkey on the Germination Success of the African Ebony (Diospyros mespiliformis)
Authors: Toni Hermann Cyr , Djossa Bruno Agossou , Fandohan Adande Belarmain 
Published: June 2023

Abstract
Animals deliver an important ecosystem service by dispersing plant seeds. Seed dispersers have different effects on the germination success of seeds. This study aimed at examining the effect of seed processing by the patas monkey (Erythrocebus patas) and two flying foxes (Micropteropus pusillus and Epomophorus gambianus) on the germination success of African ebony (Diospyros mespiliformis). Flying foxes and patas monkeys were kept in cages and fed ad libitum with African ebony fruits. Seeds processed were collected, measured, and germinated. Seeds processed by monkeys and flying foxes were compared to control seeds which were removed by hand from fruits. Our results showed that the patas monkey and flying foxes preferably processed smaller seeds. Flying foxes improved the germination success from 6.67 to 72.5%. They also reduced the mean germination time up to 5 days. The patas monkey also improved the germination success from 6.67 to 52.5% and reduced the mean germination time up to 4 days. The effect of flying foxes and the patas monkey on the seed germination and its implication for the African ebony plantation dynamic should be explained to communities for their conservation.
Social media platforms in sustainability communication of Polish social enterprises from the IT industry and beyond
Authors: Baran Michał 
Published: June 2023

Abstract
The article aims to identify and compare behaviour patterns of Polish social enterprises, especially those operating in the IT branch and using social media to communicate with their clients. The research consisted of a multidimensional qualitative and quantitative content analysis, including Cramér’s V correlation coefficient based on chi-squared statistic, also suitable for nominal data types. The article focused on client communication content created and placed on social media by Polish social enterprises from the IT and other branches. The research sample comprised 301 entities. According to the adopted assumption, the statistical research (correlation analysis) results showed certain behaviour patterns within the scope of the analysed area and revealed significant circumstances that affect communication. Due to the profile of professional competencies, the IT industry prefers communicating via social media, which aims to formulate a concise and precise message. Social enterprises in the group of the most economically effective entities have a unique way of using social media. They choose the most popular social media and, at the same time, to some extent, expand their communication to more specialised platforms. The applied approach is a new way to analyse social enterprise activities in social media. The analysis findings contribute to a greater understanding of connections between the discussed phenomena. The presented research procedure can be applied to determine the impact of other competencies of the analysed entities on sustainability communication in social media. According to research, IT entities enrich the current trends in social media use by social enterprises. The research results may be useful for banks, investors and public institutions forecasting the success of social enterprises and making support-related decisions. The scale and scope of the use of social media platforms for communication with the market may be a criterion in measuring the chances to commercialise goods and services offered by social enterprises.
Trip planning mobile application: a perspective case study of user experience
Authors: Pawełoszek Ilona , Wieczorkowski Jędrzej 
Published: June 2023

Abstract
Mobile trip planning applications may contribute to popularising public transport, provided they work efficiently and gain high user acceptance. This article aims to take a closer look at the functioning of the JakDojade application, which has been the most popular platform in Poland for several years, supporting travel planning by public transport. In the presented case study, the authors tried to diagnose problems and indicate the directions of application development. At the same time, through this analysis, the authors aimed to demonstrate the usefulness of researching user comments from the viewpoint of managing the development of mobile applications and related services. A case study methodology was used to perform a descriptive study. Data on user feedback on JakDojade mobile application in Poland comes from Google Play Store. Semantic categorisation of user comments and sentiment analysis allowed for identifying user problems and diagnosing emotions related to its use. The presented methodology allowed for diagnosing typical user problems for the JakDojade application, which may help indicate further development directions. The authors attempted to demonstrate the usefulness of researching user comments from the point of view of managing the development of mobile applications and related services. The semi-automatic approach to text analysis presented in the article highlights the problems related to the study of user reviews. The limitations of the proposed methodology and the possibilities for its improvement were indicated.
Analysis of conditions for supporting employee safety during the COVID-19 pandemic in manufacturing companies in Poland
Authors: Wronka Anna 
Published: June 2023

Abstract
The COVID-19 pandemic has significantly and permanently changed modern life in the private and professional dimensions, where numerous consequences of the virus have affected employees and employers. Both groups were forced to implement numerous changes to ensure the work process’s safety. The multi-dimensionality of this concept and, consequently, the multi-directionality of its potential and required actions taken by companies have become the basis for a theoretical and practical analysis of conditions for supporting broadly understood employee safety during the COVID-19 pandemic in selected production companies in Poland. The pilot studies’ results indicated the leading direction and scope of actions taken so far, their main types, stimulating factors and barriers, perceived benefits and future trends. The article’s conclusions may form the basis for universal good practices supporting the safety of employees in the production sector, which, regardless of the duration of the pandemic, may be used as effective and efficient improvement measures in generating measurable benefits for all stakeholders.
Additional records on the occurrence of two alien Leguminosae in Algeria
Authors: Sakhraoui Nora , Verloove Filip , Hadef Azzedine , Rouidi Sonia , Dziri Hamdi 
Published: June 2023

Abstract
During field surveys, carried out between 2021 and 2022 in northeastern Algeria, two populations of Tipuana tipu (Benth.) Kuntze were discovered. One population was located in the middle of a quite natural habitat in the Filfilla region (wilaya of Skikda). This population seems more or less established and can be considered to be at the beginning of the naturalization process, a degree of naturalization not previously reported in Algeria and mainland North Africa. The surveys also revealed several populations of Paraserianthes lophantha (Vent.) I.C. Nielsen, a species that was recently reported as naturalized in Algeria but for which details on its naturalization were lacking. Details about the localities in which the two species were observed are given, including a present map of their distribution and field photographs. A key for the identification of both genera is also provided.
Diversity of Epipactis palustris (L.) Crantz (Orchidaceae) pollinators and visitors in conditions of Kyiv city (Ukraine)
Authors: Gnatiuk Alla M. , Gaponenko Mykola B. , Honchar Hanna Y. , Gaponenko Andrii M. 
Published: June 2023

Abstract

Epipactis palustris (L.) Crantz is a protected species in Ukraine. In order to organize optimal protection measures comprehensive studies of various aspects of its biology are necessary. The aim of this study was to determine the pollinators and visitors of E. palustris. The study was conducted in Kyiv city (Ukraine) between 2020 and 2022. The research focused on arthropod visitors in two human-made populations. Specimens of 31 families and 48 genera from 9 arthropod orders were identified and established. The greatest number of species represented Hymenoptera, Coleoptera and Diptera. Evaluation of visitor activity show that Hymenoptera were the most frequent visitors. E. palustris in the conditions of Kyiv is mainly characterized by entomophily. Halictidae, Apidae and Coccinellidae played an important role in E. palustris pollination. It was found that populations of E. palustris in the conditions of the Kyiv city form a unique self-regulating biocenosis that provides shelter and food for 53 identified species of arthropods.
Compliance and its Contributions to Safety at Work
Authors: Barbosa Paula Andrea Ramirez 
Published: June 2023

Abstract
Labour compliance is essential to protect workers’ rights and promote sustainable, responsible and effective business development. It necessitates continuous preparation of preventive compliance reports on occupational risks, usually requiring studies and their timely updates, risk analysis, training-oriented resource management, and training of workers and managers. Greater self-regulation, such as compliance, can help mitigate risk of penal sanctions for individuals who fail to comply with risk prevention regulations, seriously endangering health and safety at work. A robust and effective compliance programme in this area aims to ensure legal and contractual obligations are met, particularly with respect to protecting the life and health of workers. Compliance can also bolster company success, minimise reputational damage for corporations, avoid payment of hefty fines and suspension of permits and licenses that would halt operations, among others.
Amendment to the Rights and Obligations of a Journalist in Act: Press Law from the Perspective of Conscience Clause
Authors: Sobczak Jacek , Gołda-Sobczak Maria 
Published: June 2023

Abstract
The conscience clause, sometimes also referred to as the right to conscientious objection, is based on the possibility of refusing to comply with a binding legal norm due to its non-conformity with the indications of conscience of the person who invokes its content. Commonly derived, especially in Poland, from Article 53 of the Constitution of the Republic of Poland, this clause initially applied to physicians’ actions. It was also suggested that this clause could form the basis for conscientious objection to an abortion procedure. Drawing on Article 10(2) of the Charter of Fundamental Rights of the European Union, and emphasising the differences in the wording of this provision in different language versions, the article argues that such interpretation of the conscience clause is too narrow and poor. Attention is drawn to the amendments made to the wording of Article 10(2) of the Press Law, where the legislator replaced the journalist’s obligation to follow the editorial policy with the right to refuse to carry out an official order if the journalist believed that they were expected to publish a material that would violate the principles of reliability, objectivity and professional diligence. This solution undoubtedly constitutes the approval of the broadly understood conscience clause explicitly formulated in the Charter of Fundamental Rights of the European Union. The content of Article 10(2) of the EU Charter of Fundamental Rights allows for conscientious objection to apply to actions of the representatives across all professions.