bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of sepsis and prevalence of multidrug‐resistant organisms in pediatric cardiac surgery in tertiary care teaching rural hospital in India: A retrospective observational study
Authors: Bhende Vishal V. , Pathan Sohilkhan R. , Sharma Tanishq S. , Kumar Amit , Majmudar Hardil P. , Patel Vishal A. 
Published: April 2023

AbstractBackground and aimsCardiac surgery and cardiopulmonary bypass result in an immunoparalyzed state in children making them susceptible to sepsis and other hospital‐acquired infections. Therefore, identification of the risk factors of sepsis would lead to appropriate management. The current study seeks to evaluate the prevalence of sepsis and risk factors linked to sepsis in pediatric cardiac surgical patients and the subsequent prevalence of multidrug‐resistant organisms.MethodsA retrospective, single‐center observational study was conducted including 100 pediatric patients admitted to the pediatric intensive care unit (ICU) after cardiac surgery between January 2017 and February 2018. All patient data were obtained from the medical record department of the hospital. Patient case report form comprised demography, surgery details, preoperative and postoperative hematological reports, and clinical details. After collecting the data, chi‐square test and logistic regression analysis were used to determine the risk factors linked to sepsis.ResultsThe prevalence of sepsis in our population was 27% and the mortality rate due to sepsis was 1%. The only statistically significant risk factor for sepsis we discovered in this analysis was prolonged ICU stay for more than 5 days. A total of eight patients had blood cultures positive for bacterial infection. The alarming finding was that all eight were infected with multidrug‐resistant organisms, demanding the last line of antibacterials.ConclusionOur study indicates that special clinical care is required when ICU stay is prolonged to lower the risk of sepsis. These new and upcoming infections not only promote high mortality and morbidity rates but also contribute to increased cost of care due to the use of newer broad‐spectrum antibiotics and longer hospital stay. The high prevalence of multidrug‐resistant organisms is unacceptable in the current scenario and hospital infection and prevention control play a crucial role in minimizing such infections.
Effective training program for antenatal diagnosis of placenta accreta spectrum disorder
Authors: Watcharasin Pattharapa , Pranpanus Savitree , Suwannanon Ruedeekorn , Rajaborirug Songyos 
Published: April 2023

AbstractObjectiveTo develop and evaluate a training program for diagnosing placenta accreta spectrum (PAS) disorder in obstetrics/gynecology and radiology residents.MethodsThis single‐center prospective study was based on 177 ultrasound images of pathologically confirmed PAS extracted from 534 cases of placenta previa suspicious for PAS. First‐ to third‐year residents were evaluated before training to assess experience and ability to diagnose PAS. They attended a principal lecture followed by weekly self‐study exercises over 5 weeks. Post‐course tests evaluated the efficacy of the training program for improving diagnosis of PAS after the program.ResultsTwenty‐three (38.3%) obstetrics/gynecology and 37 (61.7%) radiology residents were trained. Before the training program, 98.3% reported minimal experience and 100% low confidence to correctly diagnose PAS. During the program, the overall accuracy of all participants in diagnosing PAS increased from 71.3% before to 95.2% after training (P < 0.001). Regression analyses showed that ability to diagnose PAS increased 2.52‐fold (P < 0.001) following the program. The retention of knowledge at 1, 3, and 6 months posttest was 84.7%, 87.5%, and 87.7%, respectively.ConclusionAn antenatal diagnosis of PAS training program can be effective as a residency training program, considering the globally rising cesarean delivery rates.
Reflections on the Infant Mental Health Endorsement® process in Virginia
Authors: Dye Kasey , Spence Christine , Brock Jackie Robinson 
Published: April 2023

AbstractThis study was conducted to gather information to inform key stakeholders in Virginia's Early Childhood Mental Health workforce who are involved in the Infant Mental Health Endorsement®. An “Endorsement® indicates an individual's efforts to specialize in the promotion and practice of infant or early childhood mental health within his/her own chosen discipline” (Virginia Association for Infant Mental Health, 2021). The following research questions guided this study: (1) who is part of the infant mental health endorsed workforce in Virginia; (2) what are the benefits and barriers to the Endorsement® process. A total of 115 individuals who were or are involved in the Endorsement® as endorsees or advisors were participants in the study. Participants cited many benefits of obtaining their Infant Mental Health Endorsement®, including general professional development and connecting to other professionals in the field. Barriers to obtaining the Endorsement® included time and financial restraints related to obtaining reflective supervision from a qualified Reflective Supervisor. Results from the study will be used to inform the Infant Mental Health Endorsement® process, and applied to the Early Childhood Mental Health Endorsement® in 2023.
Janus kinase inhibitor ruxolitinib in combination with nilotinib and prednisone in patients with myelofibrosis (RuNiC study): A phase Ib, multicenter study
Authors: Ayala Rosa , Fernández Rafael Alonso , García‐Gutiérrez Valentín , Alvarez‐Larrán Alberto , Osorio Santiago , Sánchez‐Pina Jose M. , Carreño‐Tarragona Gonzalo , Álvarez Noemi , Gómez‐Casares María Teresa , Duran Antonia , Gorrochategi Julian , Hernández‐Boluda Juan Carlos , Martínez‐López Joaquín 
Published: April 2023

AbstractThis phase Ib, non‐randomized, open‐label study evaluates the safety and tolerability of ruxolitinib in combination with nilotinib and prednisone in patients with naïve or ruxolitinib‐resistant myelofibrosis (MF). A total of 15 patients with primary or secondary MF received the study treatment; 13 patients had received prior ruxolitinib treatment (86.7%). Eight patients completed seven cycles (53.3%) and six patients completed twelve cycles of treatment (40%). All the patients experienced at least one adverse event (AE) during the study (the most common AEs were hyperglycemia, asthenia, and thrombocytopenia), and 14 patients registered at least one treatment‐related AE (the most common treatment‐related AEs were hyperglycemia (22.2%; three grade 3 cases). Five treatment‐related serious AEs (SAEs) were reported in two patients (13.3%). No deaths were registered throughout the study. No dose‐limiting toxicity was observed. Four out of fifteen (27%) patients experienced a 100% spleen size reduction at Cycle 7, and two additional patients achieved a >50% spleen size reduction, representing an overall response rate of 40% at Cycle 7. In conclusion, the tolerability of this combination was acceptable, and hyperglycemia was the most frequent treatment‐related AE. Ruxolitinib in combination with nilotinib and prednisone showed relevant clinical activity in patients with MF. This trial was registered with EudraCT Number 2016‐005214‐21.
Mechanics of leukemic T‐cell
Authors: Bui Van‐Chien , Nguyen Thi‐Huong 
Published: April 2023

AbstractCell mechanics is a factor that determines cell growth, migration, proliferation, or differentiation, as well as trafficking inside the cytoplasm and organization of organelles. Knowledge about cell mechanics is critical to gaining insight into these biological processes. Here, we used atomic force microscopy to examine the elasticity, an important parameter of cell mechanics, of non‐adherent Jurkat leukemic T‐cells in both interphase and mitotic phases. We found that the elasticity of an individual cell does not significantly change at interphase. When a cell starts to divide, its elasticity increases in the transition from metaphase to telophase during normal division while the cell is stiffened right after it enters mitosis during abnormal division. At the end of the division, the cell elasticity gradually returned to the value of the mother cell. These changes may originate from the changes in cell surface tension during modulating actomyosin at the cleavage furrow, redistributing cell organelles, and constricting the contractile ring to sever mother cell to form daughters. The difference in elasticity patterns suggests that there is a discrepancy in the redistribution of the cell organelles during normal and abnormal division.
Characteristics, level of evidence, and impact of clinical studies on peri‐implantitis: 2017 to 2021
Authors: Zhao Yaoyu , Yan Qi , Wu Xinyu , Hua Fang , Shi Bin 
Published: April 2023

AbstractBackgroundThe level of evidence (LOE) is an important tool in current evidence‐based practice and clinical research. However, in clinical studies on peri‐implantitis, the present status of the LOE and its association with research impact remains to be determined. The present study aimed to gather the characteristics and LOE of clinical studies on peri‐implantitis conducted from 2017 to 2021 and assess the association of the LOE with social and scientific impact.MethodsThe PubMed database was searched to retrieve clinical studies that evaluated peri‐implantitis‐related healthcare interventions and were published between 2017 and 2021. A 4‐level modified Oxford 2011 LOE tool was used to determine the LOE of these studies. Citation count and Altmetric Attention Scores (AAS) were derived from the Web of Science and Altmetric Explorer, respectively. Multivariate generalized estimation equation (GEE) analysis was conducted to explore relationships between the LOE and citation count, and between the LOE and AAS; the publication year was considered the grouping factor for adjusting for potential clustering effects.ResultsTwo hundred and thirty‐five studies were considered eligible. The percentages by level from Level‐1 to Level‐4 were 9.8%, 35.7%, 28.9%, and 25.5%. Multivariable GEE analyses revealed that studies with higher LOE ratings had significantly greater citation counts (p = 0.008). However, no significant association (p = 0.872) was observed between the LOE and AAS.ConclusionsFrom 2017 to 2021, more than 40% of studies published on peri‐implantitis each year had high‐LOE ratings. High‐LOE studies showed a tendency to have greater scientific impact.
Chemical, biochemical and volatile profiles of saffron (Crocus sativus L.) from different growing areas of Morocco
Authors: Naim Nadia , Guirrou Ibtissame , Fauconnier Marie‐Laure , Hafida Hanine , Tahiri Abdessalem , Madani Ilham , Lahlali Rachid , Ennahli Said 
Published: April 2023

AbstractBackgroundThe saffron (Crocus sativus L.) planted area and production increased in the past decade in Morocco. This crop has been extended to new regions beyond its original main area due to the shift in climate conditions. Therefore, this study aimed to investigate the chemical characterization and the quality of saffron stigma samples collected from 11 different localities.ResultsAccording to the ISO3632 standard method, all samples were within the ISO36‐32.2010 categorization range (category I and II) Contents of crocin responsible for color, picrocrocin responsible for taste, and safranal responsible for the aroma, showed significant differences between samples from different areas. The biochemical analysis revealed that samples from Boulmane (Serghina and El Mers) are rich in polyphenols (5.70 ± 0.34; 5.31 ± 0.004 mg GAE/g DW, respectively) and have an important antioxidant power (IC50 for the DPPH: 231.12 ± 1.065; 236.77 ± 2109 respectively) compared to those from Taznakht and Taliouine known for their higher organoleptic quality. Interestingly, volatile profiling by gas chromatography–mass spectrometry identified the safranal, isophorone, ketoisophorone, ß‐isophorone, and 1‐4‐cyclohexanedione, 2,2,6‐trimethyl as the main volatile compounds in saffron samples from different regions.ConclusionThis study is the first to be conducted in Morocco on saffron newly cultivated in new regions (Boulmane, Azilal, and Ain Leuh) and showed the higher potential for growing saffron, thus promoting the adoption of saffron as a substitute crop for the socio‐economic development in these new areas.
Role of bran particles in the formation of dark spots on fresh wet noodle sheets: what are the dark spots?
Authors: Zhao Yang , Huang Ze‐Hua , Zhou Hui‐Ming , Ma Liang , An Yan‐Xia , Abddollahi Mehdi , Zhang Jian , Yin Gui‐Hong 
Published: April 2023

AbstractBackgroundDark spots may affect the appearance of fresh noodles during storage, even when made from flour with low ash content. The effect of flour bran content on the degree of dark spot formation in fresh wet noodle sheets (FWNS) is investigated to explain this phenomenon.ResultsConfocal laser scanning microscopy (CLSM) observation revealed that the wheat bran particles were responsible for the formation of dark spots on FWNS, with each bran particle core generating a single dark spot. In wheat flours with low ash content, the number of wheat bran particles causing dark spot formation on FWNS was limited, and these particles were not visible to the naked eye until their size exceeded approximately 50 μm. Tropolone, a polyphenol oxidase inhibitor (PubChem CID: 24900578) and dry heating treatment, which inactivates polyphenol oxidase, was found to inhibit or reduce the formation of dark spots.ConclusionBased on these findings, it can be concluded that bran particles, rich in polyphenol oxidase, play a key role in dark spot formation. © 2023 Society of Chemical Industry.
In‐office KTP laser treatment for laryngeal pathologies: 5‐years outcomes
Authors: Lahav Yonatan , Pinhas Sapir , Shapira‐Galitz Yael , Warman Meir , Cohen Oded , Shoffel‐Havakuk Hagit , Tessler Idit 
Published: April 2023

AbstractIntroductionIn the past two decades, laser systems were introduced into the office setting for laryngeal pathologies, offering the advantages of a shorter procedure and recovery. To date, long‐term data on outcomes is limited. This study aims to evaluate the efficacy and safety of the office‐based potassium‐titanyl‐phosphate (KTP) laser procedure for laryngeal pathologies.MethodsA retrospective cohort of in‐office KTP laser procedures for two main vocal folds lesions groups: (i) benign and pre‐malignant; and (ii) intraepithelial lesions in a prior invasive cancer field between 2010 and 2020. Data were collected from electronic medical records, telephone interviews, and video documentation of the procedure, including treatment completion, disease control, and whether additional interventions were required.ResultsA total of 81 patients underwent 153 in‐office KTP laser procedures for benign (36, 44.4%), pre‐malignant (15, 18.5%), and lesions in a prior malignancy field (30, 37.1%) with a mean of 1.89 ± 1.81 procedures per patient. One hundred and thirty‐eight (90.2%) procedures were well tolerated and completed successfully. During the 5‐years of follow‐up, 63% of the patients with previous malignancy were managed exclusively in the office. In the pre‐malignant group, 76% required no additional type of intervention. Patients with papilloma required significantly more procedures per patient compared with other pathologies (3.6 ± 4 vs. 1.61 ± 1, p‐value = 0.02). Surgery was required only in 18.2% of the papilloma patients. Three (1.9%) patients had short‐term complications, all resolved within 6 months. Failure to complete the procedure was significantly associated with active smoking (p‐value < 0.001) and, in most cases (90%), was related to patient intolerance.ConclusionOffice‐based KTP laser laryngeal procedures have shown promising results for both benign and selected cases of lesions in a prior malignancy field with a high compliance and a very low complication rate, suggesting its use as an effective and safe treatment modality for selected patients.
A prospective pilot study to assess for histologic changes on vulvar biopsies in postmenopausal women with lichen sclerosus treated with fractionated CO2 laser therapy
Authors: Dieter Alexis A. , Iglesia Cheryl B. , Lee Jennifer H. , Etcheverry Maria J. , Gonzales Melissa K. , Sokol Andrew I. , Tefera Eshetu , Cardis Michael A. 
Published: April 2023

AbstractObjectivesTo investigate the histologic characteristics of vulvar tissues before and after completion of fractionated carbon dioxide (CO2) laser therapy (FxCO2) for vulvar lichen sclerosus (LS). The secondary objective was to assess subjective improvement in symptoms via the Skindex‐16 questionnaire.MethodsThis prospective single‐arm study was conducted from April 2021 to August 2022 at one academic medical center. Ten postmenopausal women with biopsy‐proven LS planning FxCO2 laser treatment were enrolled. Exclusion criteria included prior transvaginal mesh for prolapse, topical corticosteroid use within 8 weeks, prior pelvic radiation, malignancy, active genital infection, or pregnancy. The vulvovaginal SmartXide2‐V2‐LR laser system fractionated CO2 laser (DEKA) was utilized to treat visually affected areas of vulvar and perianal LS with a single pass. Subjects underwent three treatments 4–6 weeks apart. Subjects completed the Skindex‐16 questionnaire and had vulvar biopsy at baseline and at 4 weeks after completion of fractionated CO2 laser therapy. Blinded histologic slides were scored by one dermatopathologist (Michael A. Cardis) rating from 1 to 5 the degree of dermal sclerosis, inflammation, and epidermal atrophy. Change scores were calculated as the difference between pre‐ and post‐treatment scores for each subject.ResultsThe 10 subjects enrolled had a mean age of 61 and most were white, privately insured, and had a college/graduate‐level education. Post‐fractionated CO2 laser treatment vulvar biopsies showed significant improvement in sclerosis and epidermal atrophy compared with pretreatment baseline biopsy specimens (p < 0.05) with no statistically significant change found in inflammation score. Skindex‐16 and FSFI scores showed a trend towards improvement (p > 0.05 for both). A statistically significant correlation was found between change in sclerosis and Skindex‐16 symptoms scores with an average change of 21.4 units in Skindex‐16 symptoms score for every one‐point change in histologic sclerosis score (p = 0.03).ConclusionsIn postmenopausal women with vulvar LS undergoing fractionated CO2 laser, symptomatic improvements correlated with histologic change in degree of sclerosis on vulvar biopsy. These results demonstrate FxCO2 laser therapy as a promising option for the treatment of LS and suggest that further studies should assess degree of sclerosis on histopathology.
Inside‐Out Surgical Anatomy of Superior Laryngeal Artery Endoscopic Dissection and Proposal for Nomenclature of Branches
Authors: Saleh Hazem M.A. , Jöns Thomas , Mürbe Dirk , Nawka Tadeus 
Published: April 2023

AbstractObjectivesTo describe the inside out surgical anatomy of the superior laryngeal artery and to resolve the ambiguities in the nomenclature of its main branches.Study DesignEndoscopic dissection of the superior laryngeal artery in the paraglottic space of larynges of fresh frozen cadavers and a review of the literature.SettingA center for anatomy encompassing facilities for latex injection into the cervical arteries of human donor bodies and a laryngeal dissection station equipped with a video‐guided endoscope and a 3‐dimensional camera.MethodsVideo‐guided endoscopic dissection of 12 hemilarynges in fresh frozen cadavers whose cervical arteries were injected with red latex. Description of the inside‐out surgical anatomy of the superior laryngeal artery and its main branches. Review of the previous reports describing the anatomy of the superior laryngeal artery.ResultsFrom inside the larynx, the artery was exposed upon its entry through the thyrohyoid membrane or through the foramen thyroideum. It was traced ventrocaudally in the paraglottic space exposing its branches to the epiglottis, the arytenoid, and the laryngeal muscles and mucosa. Its terminal branch was followed until it left the larynx through the cricothyroid membrane. Branches of the artery, previously described under different names, appeared to supply the same anatomical domains.ConclusionMastering the inside out anatomy of the superior laryngeal artery is mandatory to control any intraoperative or postoperative hemorrhage during transoral laryngeal microsurgery or during transoral robotic surgery. Naming the artery's main branches according to their domain of supply would resolve the ambiguities resulting from various nomenclatures.
Thermal protection materials based on epoxy‐containing and phenyl‐containing polyhedral oligomeric silsesquioxane modified phenolic resin and phenolic resin/carbon fiber composites
Authors: Yang Fan , Li Jian , Zhang Wenchao , He Jiyu , Yang Rongjie , Huang Jianfeng , Zhang Xin , Zhang Wenyuan 
Published: April 2023

AbstractEpoxy‐containing and phenyl‐containing polyhedral oligomeric silsesquioxane (EP‐POSS) and EP‐POSS modified phenolic resin (PR) was prepared, and its mechanical, thermodynamic and ablative properties were characterized. The results show that EP‐POSS can effectively improve the mechanical properties, thermal stability and ablative performance of PR. In the process of ablative, EP‐POSS decomposition forms a protective layer of silica, which covers the surface of the material, slows down the erosion of the internal material by high temperature heat flow, and effectively reduces the ablative rate of the material. EP‐POSS modified PR/CF (carbon fiber) composite was prepared and its ablative performance was studied. The results show that the modified material has excellent ablative resistance, and its linear ablative rate is close to 0.
Gamma generalized linear model‐based control charts for high‐purity processes
Authors: Rizzo Caterina , Bucchianico Alessandro Di 
Published: April 2023

AbstractStatistical process monitoring of high‐purity manufacturing processes becomes challenging if the defect rate depends on the fluctuations of a set of covariates (e.g., inspected weight, volume, temperature). This paper applies the generalized linear model framework to statistical process control for detecting contextual anomalies in high‐purity processes. Different types of predictive residuals (i.e., Pearson, deviance, and quantile) and recursive residuals are considered, and the performance of these schemes is compared via a simulation study.
Reliability study of generalized exponential distribution based on inverse power law using artificial neural network with Bayesian regularization
Authors: Sindhu Tabassum Naz , Çolak Andaç Batur , Lone Showkat Ahmad , Shafiq Anum 
Published: April 2023

AbstractThe investigation of lifetime reliability analysis is vital for confirming the quality of devices, equipment, electronic tube flops, and so forth. Statistical investigators have become more interested in lifetime model exploration in recent years, particularly in the last decade, without considering the issue of modeling the metrics of model reliability using artificial neural networks (ANNs). This study addresses this vacuum by discussing the multilayer ANN with Bayesian regularization modeling for reliability metrics of generalized exponential model based on inverse power law (IPL). The numerical findings of the reliability investigations and the values obtained from the ANN have been examined and analyzed carefully. The findings show that ANNs are a powerful and useful mathematical tool for analyzing the reliability of lifetime model based on IPL. Finally, a real life framework is implemented that support the theory of a research study.