bluuebunny/crossref_metadata_2025_split huggingface dataset:
On ‘Safety’ and EU Externalization of Borders:
Authors: Giuffré Mariagiulia , Denaro Chiara , Raach Fatma 
Published: December 2022

Abstract
This article questions whether Tunisia – a country of departure, transit and destination of migrants and refugees, and a key interlocutor in EU externalization and readmission policies – can be considered a “safe country of origin” for Tunisian nationals and a “safe third country” for foreigners in search of protection. In discussing the rapidly evolving domestic legal and political system and the treatment of minorities, vulnerable groups, and refugees in Tunisia, this article adopts a socio-legal perspective also relying on interviews with key stakeholders.
Finally, it proposes a reflection on the main (conceptual and empirical) elements of continuity between the “safe country of origin” notion and the “safe third country” one, by highlighting their deep relationship, how they may mutually influence each other, and the need to reconnect various perspectives on safety, avoiding reproducing Eurocentric analytic approaches, interpretations, and narratives.
Contemplating the Lundy Model as a Framework for Children’s Participation in Peace Negotiations
Authors: Molloy Sean 
Published: December 2022

Abstract
Peace agreements attempt to do more than end war. Ostensibly, they can also serve as the foundation for a new post-conflict state, one underpinned by fairness, equality and inclusion. Ensuring that children’s issues are included in a peace accord is, therefore, viewed as essential for the realisation of their rights in the post-conflict state. Yet there is scant consideration dedicated to understanding or theorising how and whether the perspectives of children can be heard during peace negotiations. This is despite research demonstrating that who is included in peace talks can impact the content of the subsequent peace agreement. This article considers the potential benefits and challenges associated with applying the Lundy Model of child participation to peace negotiations. It argues that while difficulties are likely to exist, this framework could provide a useful starting point for thinking more seriously about the possibilities and avenues that exist for the inclusion of children’s voices during peace talks.
From Politics of Location to Its De-politicization in One Man’s Bible by Gao Xingjian
Authors: Chishti Farida 
Published: December 2022

Abstract
Drawing on the Deleuzian theory of de-territorialization of the subject from the center of power, this article picks up the controversy regarding Gao Xingjian’s misogyny with reference to his second novel One Man’s Bible and presents an alternative perspective on his gender treatment. With the help of textual analysis, it contends that far from being anti-feminist as is generally assumed in critical circles, Gao is gender neutral, and allows the same subjective agency to woman as man. Both male and female protagonists in the novel tend to hegemonize each other on the basis of their location in the geo-political or socio-cultural scale of power until each dislocates from his/her power base to undergo a qualitative transformation that changes their world view. It is their minority position which helps them surmount their tendency to hegemonize or minoritize the other and thus to become “minortarian.”
Cardiopulmonary bypass parameters improve the prediction of 30-day mortality following cardiac surgery
Authors: Newland Richard F , Baker Robert A 
Published: December 2022

Currently 30-day mortality is commonly used as a quality indicator for cardiac surgery; however, prediction models have not included the role of cardiopulmonary bypass (CPB). We hypothesized that reproducing currently utilised prediction model methods of 30-day mortality using the Australian and New Zealand Collaborative Perfusion Registry (ANZCPR) would identify relevant CPB predictors. Nine centers in Australia and New Zealand collected data using the ANZCPR between 2011–2020. CPB parameter selection was determined by evaluating association with 30-day mortality. Data were divided into model creation ( n = 15,073) and validation sets ( n = 15,072). Bootstrap sampling and automated variable selection methods were used to develop candidate models. The final model was selected using prediction mean square error and Bayesian Information Criteria. The average receiver operating characteristic (ROC), p-value for Hosmer—Lemeshow chi-squared test and MSE were obtained from multifold validation. In total, 30,145 patients were included, of which 735 (2.4%) died within 30 day of surgery. The area under the ROC curve for the model including CPB parameters was significantly greater than preoperative risk factors only (0.829 vs 0.783, p < 0.001). CPB parameters included in the predictive model were CPB time, red blood cell transfusion, mean arterial pressure <50 mmHg, minimum oxygen delivery, cardiac index <1.6 L/min/m2. CPB parameters improve the prediction of 30-day mortality. Randomised trials designed to evaluate modifiable CPB parameters will determine their impact on mortality.
Understanding parent experiences of end-of-life care for children: A systematic review and qualitative evidence synthesis
Authors: Barrett Laura , Fraser Lorna , Noyes Jane , Taylor Jo , Hackett Julia 
Published: December 2022

Background: An estimated 21 million children worldwide would benefit from palliative care input and over 7 million die each year. For parents of these children this is an intensely emotional and painful time through which they will need support. There is a lack of synthesised research about how parents experience the care delivered to their child at the end of life. Aim: To systematically identify and synthesise qualitative research on parents’ experiences of end-of-life care of their child. Design: A qualitative evidence synthesis was conducted. The review protocol was registered in PROSPERO (CRD42021242946). Data sources: MEDLINE, EMBASE, CINAHL, PsycINFO and Web of Science databases were searched for qualitative studies published post-2000 to April 2020. Studies were appraised for methodological quality and data richness. Confidence in findings was assessed by GRADE-CERQual. Results: About 95 studies met the eligibility criteria. A purposive sample of 25 studies was taken, of good-quality papers with rich data describing the experience of over 470 parents. There were two overarching themes: parents of children receiving end-of-life care experienced a profound need to fulfil the parental role; and care of the parent. Subthemes included establishing their role, maintaining identity, ultimate responsibility, reconstructing the parental role, and continuing parenting after death. Conclusions: Services delivering end-of-life care for children need to recognise the importance for parents of being able to fulfil their parental role and consider how they enable this. What the parental role consists of, and how it’s expressed, differs for individuals. Guidance should acknowledge the need to enable parents to parent at their child’s end of life.
Deific Figures and Human Bodies: Creating Hierarchies of Difference through the Incarnation of Moral Authority
Authors: Schnabel Elaine 
Published: December 2022

Religious communities have long affirmed the agency of their sacred texts and their God/gods, providing a unique site of study for research on ventriloquizing authority, textual agency, and the power of incorporeal figures like values or principles. This paper uses PraiseMoves, an Evangelical organization selling a “Christian alternative to yoga,” as a case study to develop the concept of deific agency. Deific agency is the agential power of incorporeal projections of moral authority. These projections mediate text-human relationships both in and beyond particular organizational contexts by imbuing visibly-privileged human bodies with moral authority. Deific figures can thus overwhelm textual agency by bonding with visibly-privileged bodies and thereafter organizing perceptions of moral authority in and beyond organizations in ways that disproportionately benefit physically-privileged human beings. This paper concludes by articulating the value of believing bodies for research and suggesting future avenues of inquiry.
Cardiovascular events and risk in patients with systemic lupus erythematosus: Systematic literature review and meta-analysis
Authors: Bello Natalia , Meyers Kristin J , Workman Jennifer , Hartley Louise , McMahon Maureen 
Published: December 2022

Background Systemic lupus erythematosus (SLE) is an autoimmune disease that typically affects women aged 16–55 years. Cardiovascular disease (CVD) is a well-recognized complication of SLE. This systematic literature review and meta-analysis evaluated the relative risk (RR; compared with non-SLE controls), absolute risk (AR; as incidence proportion, n/N), and incidence rate (IR) of CVD events (including stroke, myocardial infarction [MI], and CVD [composite or undefined]) in adult patients with SLE. The RR of CV risk factors (including hypertension, diabetes, and metabolic syndrome [MetS]) was also examined. Methods PubMed and Embase were searched on September 10, 2020. Observational studies published between January 2010 and September 2020 that reported RR, AR, and/or IR of CVD events, or RR of CV risk factors, were eligible. Pooled risk estimates were calculated using a random-effects model. Results Forty-six studies (16 cross-sectional, 15 retrospective cohort, 14 prospective cohort, and 1 case–control) were included in meta-analyses. Most studies were considered high quality (Critical Appraisal Skills Programme checklists). Compared with adults without SLE, patients with SLE had statistically significantly higher RRs (95% CIs) of stroke (2.51 [2.03–3.10]; 12 studies), MI (2.92 [2.45–3.48]; 11 studies), CVD (2.24 [1.94–2.59]; 8 studies), and hypertension (2.70 [1.48–4.92]; 7 studies). RRs of diabetes (1.24 [0.78–1.96]; 3 studies) and MetS (1.49 [0.95–2.33]; 7 studies) were elevated but not significant. RRs of stroke and MI were generally higher in younger versus older patients with SLE. In patients with SLE, the pooled estimate of AR (95% CI) was 0.03 (0.02–0.05), 0.01 (0.00–0.02), and 0.06 (0.03–0.10) for stroke (7 studies), MI (6 studies), and CVD (8 studies), respectively. The pooled estimate of IR per 1000 person-years (95% CI) was 4.72 (3.35–6.32), 2.81 (1.61–4.32), and 11.21 (8.48–14.32) for stroke (10 studies), MI (6 studies), and CVD (8 studies), respectively. Although heterogeneity (based on I2 value) was high in most analyses, sensitivity analyses confirmed the robustness of the pooled estimates. Conclusions This meta-analysis found an increased risk of stroke, MI, CVD, and hypertension in patients with SLE compared with the general population, despite substantial heterogeneity across the included studies.
Cost comparison of filgrastim versus pegfilgrastim and pegfilgrastim biosimilars for inpatient prophylaxis of febrile neutropenia
Authors: Singer Kaeli , Forshay Charlotte M. , Kennerly-Shah Julie 
Published: December 2022

Introduction The Ohio State University Comprehensive Cancer Center (The James) uses daily subcutaneous filgrastim as the inpatient granulocyte colony-stimulating factor of choice. The coordination of care associated with filgrastim can often be a barrier to patient discharge. The purpose of this study was to compare the inpatient cost of daily filgrastim to single dose pegfilgrastim and biosimilars. Methods Adult patients admitted to The James who received at least one dose of filgrastim between June 1, 2021 and August 31, 2021 were retrospectively identified. This study compared the inpatient cost of filgrastim and biosimilars associated with one chemotherapy cycle to the potential inpatient cost of pegfilgrastim and biosimilars based on average sales price (ASP). Additionally, the number and duration of discharge prescriptions for filgrastim was determined. Results Of the 44 unique patient encounters that met inclusion criteria, 19 received 300-mcg doses of filgrastim and 25 received 480-mcg doses. The median number of doses administered per admission was eight. If each of these patients were to instead receive the most inexpensive biosimilar, pegfilgrastim reference product, the cost would be 216% higher than with filgrastim-sndz. At discharge, 15 patients (34%) received a prescription for filgrastim to be continued for a median duration of 6 days. Conclusion Based on ASP, pegfilgrastim was more costly than filgrastim. Potential rebates and negotiation power may alter the financial outlook of adding pegfilgrastim to inpatient formulary. Exploration of delays in discharge due to insurance coordination for filgrastim continuation in the outpatient setting may also impact formulary decisions.
Risk factors associated with corneal endothelial cell density in Posner-Schlossman syndrome
Authors: Wang Qian , Zeng Weijuan , Zeng Wen , Liu Yang , Ke Min 
Published: December 2022

Purpose To investigate the risk factors related to corneal endothelial cell density (ECD) in patients with Posner-Schlossman syndrome (PSS). Patients and methods It was an observational retrospective study. We reviewed the medical records of patients with PSS who attended the ophthalmology department at Wuhan University Zhongnan Hospital from January 2019 to December 2021. 42 eyes of 42 patients with PSS were included in the study. Demographic characteristics and clinical manifestations were recorded. The clinical characteristics of PSS patients with reduced ECD were compared with PSS patients with normal ECD. Simple and multiple linear regression analyses were carried out to identify the risk factors for ECD in PSS. Results The ECD-lowered group had a longer disease duration ( P = 0.000), higher rate of occurrence of corneal edema ( P = 0.039), higher cytomegalovirus (CMV) deoxyribonucleic acid (DNA) copy number ( P = 0.044), higher interleukin-10 (IL-10) level in the aqueous humor ( P = 0.044), and thinner average retinal nerve fiber layer (RNFL) thickness ( P = 0.016) than the control group. The results of multiple linear regression analysis indicated that disease duration (β =  − 0.287, P = 0.024) and level of IL-10 in the aqueous humor (β =  − 0.408, P = 0.001) were significantly negatively associated with ECD, while average RNFL thickness (β = 0.330, P =  0.007) was significantly positively related to ECD in PSS. Conclusion A longer disease duration, higher degree of glaucomatous damage and elevated level of IL-10 in the aqueous humor were associated with reduced ECD in PSS.
An Analysis of the Social Determinants of Health in South Carolina’s I-95 Corridor
Authors: Mandelbaum Jennifer , Almeda Jennifer , Blackwell Shanikque , Hopkins John W. , Myers Kristian , Hicks Shauna , Daguise Virginie G. 
Published: December 2022

Background One in four South Carolinians lives in a county along a nearly 200-mile stretch of Interstate 95 (I-95). Stretching from North Carolina to Georgia, this region is among the most rural, economically depressed, and racially/ethnically diverse in the state. Research is needed to identify social factors contributing to adverse health outcomes along the I-95 corridor, guide interventions, and establish a baseline for measuring progress. This study assessed social determinants of health in counties in South Carolina’s I-95 corridor relative to the rest of the state. Method Data for South Carolina’s 46 counties were extracted from the Centers for Disease Control and Prevention Minority Health Social Vulnerability Index (SVI), which grouped 34 census variables into six themes: socioeconomic status, household composition and disability, minority status and language, housing type and transportation, health care infrastructure, and medical vulnerability. Each theme was ranked from 0 (least vulnerable) to 1 (most vulnerable). Measures between regions were compared using the Wilcoxon–Mann–Whitney test. Results Compared with counties outside the I-95 corridor (n = 29), counties in the corridor (n = 17) scored higher on socioeconomic status vulnerability (.67 and .82, respectively) and medical vulnerability (.65 and .79, respectively). No statistically significant differences were found across other themes. Conclusion Identifying social determinants of health in South Carolina’s I-95 corridor is a crucial first step toward alleviating health disparities in this region. Interventions and policies should be developed in collaboration with local stakeholders to address distal social factors that create and reinforce health disparities.
Association between type of intervention center and outcomes after endovascular treatment for acute ischemic stroke: Results from the MR CLEAN Registry
Authors: Olthuis Susanne GH , Hinsenveld Wouter H , Pinckaers Florentina ME , Amini Marzyeh , Lingsma Hester F , Staals Julie , HCML Schreuder Tobien , Schonewille Wouter J , Yo Lonneke SF , BWEM Roos Yvo , Postma Alida A , Dippel Diederik WJ , van Zwam Wim H , van Oostenbrugge Robert J , de Ridder Inger R 
Published: December 2022

Background: Endovascular treatment (EVT) for acute ischemic stroke (AIS) is performed in intervention centers that provide the full range of neuro(endo)vascular care (level 1) and centers that only perform EVT for AIS (level 2). We compared outcomes between these center types and assessed whether differences in outcomes could be explained by center volume (CV). Patients and methods: We analyzed patients included in the MR CLEAN Registry (2014–2018), a registry of all EVT-treated patients in the Netherlands. Our primary outcome was the shift on the modified Rankin scale (mRS) after 90 days (ordinal regression). Secondary outcomes were the NIHSS 24–48 h post-EVT, door-to-groin time (DTGT), procedure time (linear regression), and recanalization (binary logistic regression). We compared outcomes between level 1 and 2 centers using multilevel regression models, with center as random intercept. We adjusted for relevant baseline factors, and in case of observed differences, we additionally adjusted for CV. Results: Of the 5144 patients 62% were treated in level 1 centers. We observed no significant differences between center types in mRS (adjusted(a)cOR: 0.79, 95% CI: 0.40 to 1.54), NIHSS (aβ: 0.31, 95% CI: −0.52 to 1.14), procedure duration (aβ: 0.88, 95% CI: −5.21 to 6.97), or DTGT (aβ: 4.24, 95% CI: −7.09 to 15.57). The probability for recanalization was higher in level 1 centers compared to level 2 centers (aOR 1.60, 95% CI: 1.10 to 2.33), and this difference probably depended on CV. Conclusions: We found no significant differences, that were independent of CV, in the outcomes of EVT for AIS between level 1 and level 2 intervention centers.
Monitoring metrics over time: Why clinical trialists need to systematically collect site performance metrics
Authors: Yorke-Edwards Victoria , Diaz-Montana Carlos , Murray Macey L , Sydes Matthew R , Love Sharon B 
Published: December 2022

Background: Over the last decade, there has been an increasing interest in risk-based monitoring (RBM) in clinical trials, resulting in a number of guidelines from regulators and its inclusion in ICH GCP. However, there is a lack of detail on how to approach RBM from a practical perspective, and insufficient understanding of best practice. Purpose: We present a method for clinical trials units to track their metrics within clinical trials using descriptive statistics and visualisations. Research Design: We suggest descriptive statistics and visualisations within a SWAT methodology. Study Sample: We illustrate this method using the metrics from TEMPER, a monitoring study carried out in three trials at the MRC Clinical Trials Unit at UCL. Data Collection: The data collection for TEMPER is described in DOI: 10.1177/1740774518793379. Results: We show the results and discuss a protocol for a Study-Within-A-Trial (SWAT 167) for those wishing to use the method. Conclusions: The potential benefits metric tracking brings to clinical trials include enhanced assessment of sites for potential corrective action, improved evaluation and contextualisation of the influence of metrics and their thresholds, and the establishment of best practice in RBM. The standardisation of the collection of such monitoring data would benefit both individual trials and the clinical trials community.
Dupilumab increases aspirin tolerance in NSAID-exacerbated respiratory disease
Authors: Schneider Sven , Poglitsch Katharina , Morgenstern Christina , Quint Tamara , Gangl Katharina , Sinz Christoph , Bartosik Tina , Campion Nicholas James , Liu David Tianxiang , Landegger Lukas David , Tu Aldine , Stanek Victoria , Rocha-Hasler Marianne , Bangert Christine , Eckl-Dorna Julia 
Published: December 2022

BackgroundNonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (N-ERD) comprises the triad of chronic rhinosinusitis with nasal polyps, asthma and intolerance to NSAIDs. Dupilumab treatment, targeting the interleukin-4 (IL-4) receptor α, significantly reduces polyp burden as well as asthma symptoms. Here we aimed to investigate the effect of dupilumab on aspirin intolerance, burden of disease and nasal cytokine profiles in patients with N-ERD.MethodsIn this open-label trial, adult patients with confirmed N-ERD were treated with dupilumab for 6 months. Clinical parameters (e.g.total polyp scores, quality of life questionnaires, smell test, spirometry), oral aspirin provocation testing and blood, nasal and urine sampling were monitored at regular intervals for up to 6 months after starting dupilumab therapy.ResultsOf the 31 patients included in the study, 30 completed both aspirin provocation tests. After 6 months of treatment with dupilumab, 23% of patients (n=7 of 30) developed complete aspirin tolerance and an additional 33% of patients (n=10 of 30) tolerated higher doses. Polyp burden was significantly reduced (total polyp score: −2.68±1.84, p<0.001), while pulmonary symptoms (asthma control test: +2.34±3.67, p<0.001) and olfactory performance improved (University of Pennsylvania Smell Identification Test: +11.16±9.54, p<0.001) in all patients after therapy. Patients with increased aspirin tolerance showed a significant decrease in urinary leukotriene E4 levels and their improvement in clinical parameters was associated with a reduction of eotaxin-1, C-C motif chemokine ligand 17, IL-5, IL-17A and IL-6.ConclusionIn this study, 57% of N-ERD patients tolerated higher doses of aspirin under dupilumab therapy.
Construction and validation of a fatty acid metabolism risk signature for predicting prognosis in acute myeloid leukemia
Authors: Chen Miao , Tao Yuan , Yue Pengjie , Guo Feng , Yan Xiaojing 
Published: December 2022

Abstract
Background
Fatty acid metabolism has been reported to play important roles in the development of acute myeloid leukemia (AML), but there are no prognostic signatures composed of fatty acid metabolism-related genes. As the current prognostic evaluation system has limitations due to the heterogeneity of AML patients, it is necessary to develop a new signature based on fatty acid metabolism to better guide prognosis prediction and treatment selection.

Methods
We analyzed the RNA sequencing and clinical data of The Cancer Genome Atlas (TCGA) and Vizome cohorts. The analyses were performed with GraphPad 7, the R language and SPSS.

Results
We selected nine significant genes in the fatty acid metabolism gene set through univariate Cox analysis and the log-rank test. Then, a fatty acid metabolism signature was established based on these genes. We found that the signature was as an independent unfavourable prognostic factor and increased the precision of prediction when combined with classic factors in a nomogram. Gene Ontology (GO) and gene set enrichment analysis (GSEA) showed that the risk signature was closely associated with mitochondrial metabolism and that the high-risk group had an enhanced immune response.

Conclusion
The fatty acid metabolism signature is a new independent factor for predicting the clinical outcomes of AML patients.