bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catechin‐Functionalized Cationic Lipopolymer Based Multicomponent Nanomicelles for Lung‐Targeting Delivery
Authors: Jin Min , Liu Bangheng , Zhang Zhen , Mu Yulei , Ma Liang , Yao Hang , Wang Dong‐An 
Published: August 2023

AbstractCatechins from green tea are one of the most effective natural compounds for cancer chemoprevention and have attracted extensive research. Cancer cell‐selective apoptosis‐inducing properties of catechins depend on efficient intracellular delivery. However, the low bioavailability limits the application of catechins. Herein, a nano‐scaled micellar composite composed of catechin‐functionalized cationic lipopolymer and serum albumin is constructed. Cationic liposomes tend to accumulate in the pulmonary microvasculature due to electrostatic effects and are able to deliver the micellar system intracellularly, thus improving the bioavailability of catechins. Albumin in the system acts as a biocompatible anti‐plasma absorbent, forming complexes with positively charged lipopolymer under electrostatic interactions, contributing to prolonged in vivo retention. The physicochemical properties of the nano‐micellar complexes are characterized, and the antitumor properties of catechin‐functionalized materials are confirmed by reactive oxygen species (ROS), caspase‐3, and cell apoptosis measurements. The role of each functional module, cationic polymeric liposome, and albumin is revealed by cell penetration, in vivo animal assays, etc. This multicomponent micellar nanocomposite has the potential to become an effective vehicle for the treatment of lung diseases such as pneumonia, lung tumors, sepsis‐induced lung injury, etc. This study also demonstrates that it is a great strategy to create a delivery system that is both tissue‐targeted and biologically active by combining cationic liposomes with the native bioactive compound catechins.
Emerging Amorphous to Crystalline Conversion Chemistry in Ca‐Doped VO2 Cathodes for High‐Capacity and Long‐Term Wearable Aqueous Zinc‐Ion Batteries
Authors: Guo Jiabin , He Bing , Gong Wenbin , Xu Shuhong , Xue Pan , Li Chunsheng , Sun Yan , Wang Chunlei , Wei Lei , Zhang Qichong , Li Qingwen 
Published: August 2023

AbstractAmorphous transition metal oxides have attracted significant attention in energy storage devices owing to their potentially desirable electrochemical properties caused by abundant unsaturated dangling bonds. However, the amorphization further amplifies the shortcoming of the poor intrinsic electronic conductivity of the metal oxides, resulting in unsatisfying rate capability and power density. Herein, freestanding amorphous Ca‐doped V2O5 (a‐Ca‐V2O5) cathodes are successfully prepared via in situ electrochemical oxidation of Ca‐doped VO2 nanoarrays for wearable aqueous zinc‐ion batteries. The doping of Ca and construction of freestanding structure effectively uncover the potential of amorphous V2O5, which can make full use of the abundant active sites for high volumetric capacity and simultaneously achieve fast reaction kinetics for excellent rate performance. More importantly, the introduction of Ca can notably reduce the formation energy of VO2 according to theoretical calculation results and realizes amorphous to crystalline reversible conversion chemistry in the charge/discharge procedure, thereby facilitating the reversible capacity of the newly developed a‐Ca‐V2O5. This work provides an innovative design strategy to construct high‐rate capacity amorphous metal oxides as freestanding electrodes for low‐cost and high‐safe wearable energy‐storage technology.
Ultrahigh Permeability at High Frequencies via A Magnetic‐Heterogeneous Nanocrystallization Mechanism in an Iron‐Based Amorphous Alloy
Authors: Zhou Jing , Li Xuesong , Hou Xibei , Ke Haibo , Fan Xingdu , Luan Junhua , Peng Hailong , Zeng Qiaoshi , Lou Hongbo , Wang Jianguo , Liu Chain Tsuan , Shen Baolong , Sun Baoan , Wang Weihua , Bai Haiyang 
Published: August 2023

AbstractThe prevalence of wide‐bandgap (WBG) semiconductors allows modern electronic devices to operate at much higher frequencies. However, development of soft magnetic materials with high‐frequency properties matching the WBG‐based devices remains challenging. Here, a promising nanocrystalline–amorphous composite alloy with a normal composition Fe75.5Co0.5Mo0.5Cu1Nb1.5Si13B8 in atomic percent is reported, which is producible under industrial conditions, and which shows an exceptionally high permeability at high frequencies up to 36 000 at 100 kHz, an increase of 44% compared with commercial FeSiBCuNb nanocrystalline alloy (25 000 ± 2000 at 100 kHz), outperforming all existing nanocrystalline alloy systems and commercial soft magnetic materials. The alloy is obtained by a unique magnetic‐heterogeneous nanocrystallization mechanism in an iron‐based amorphous alloy, which is different from the traditional strategy of nanocrystallization by doping nonmagnetic elements (e.g., Cu and Nb). The induced magnetic inhomogeneity by adding Co atoms locally promotes the formation of highly ordered structures acting as the nuclei of nanocrystals, and Mo atoms agglomerate around the interfaces of the nanocrystals, inhibiting nanocrystal growth, resulting in an ultrafine nanocrystalline–amorphous dual‐phase structure in the alloy. The exceptional soft magnetic properties are shown to be closely related to the low magnetic anisotropy and the unique spin rotation mechanism under alternating magnetic fields.
Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment
Authors: Xiong Yao , Rao Yan , Hu Jiawei , Luo Zixuan , Chen Chuang 
Published: August 2023

AbstractRapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location and aesthetic significance render breast cancer a particularly pertinent candidate for the clinical application of PTT following melanoma. This review comprehensively explores the research conducted on the various types of nanoparticles employed in PTT for breast cancer and elaborates on their specific roles and mechanisms of action. The integration of PTT with existing clinical therapies for breast cancer is scrutinized, underscoring its potential for synergistic outcomes. Additionally, the mechanisms underlying PTT and consequential modifications to the tumor microenvironment after treatment are elaborated from a medical perspective. Future research directions are suggested, with an emphasis on the development of integrative platforms that combine multiple therapeutic approaches and the optimization of nanoparticle synthesis for enhanced treatment efficacy. The goal is to push the boundaries of PTT toward a comprehensive, clinically applicable treatment for breast cancer.
Advancements in Achieving High Reversibility of Zinc Anode for Alkaline Zinc‐Based Batteries
Authors: Xie Weili , Zhu Kaiyue , Yang Hanmiao , Yang Weishen 
Published: August 2023

AbstractRechargeable alkaline zinc‐based batteries (ZBBs) have attracted extensive research attention due to their advantages of low cost, high specific energy, and high safety. Although the investigation of cathodes for alkaline secondary ZBBs has reached a relatively advanced stage, the exploration of zinc anodes is still in its infancy. Zinc anodes in alkaline electrolytes encounter challenges such as dendrite formation, passivation, corrosion during periods of cell inactivity, and hydrogen evolution during cycling, thereby limiting their rechargeability and storability. Drawing upon the latest research on zinc anodes, six fundamental strategies that encompass a wide range of aspects are identified and categorized, from electrode modifications and electrolytes to charge protocols. Specifically, these strategies include 3D structures, coatings, alloying, additives, separators, and charge protocols. They serve as an insight summary of the current research progress on zinc anodes. Additionally, the complementary nature of these strategies allows for flexible combinations, enabling further enhancement of the overall performance of zinc anodes. Finally, several future directions for the advancement of practical alkaline Zn anode are proposed. This comprehensive review not only consolidates the existing knowledge but also paves the way for broader research opportunities in the pursuit of high‐performance alkaline zinc anodes.
Antioxidant Theranostic Copolymer‐Mediated Reduction in Oxidative Stress Following Traumatic Brain Injury Improves Outcome in a Mouse Model
Authors: Tarudji Aria W. , Gee Connor C. , Miller Hunter A. , Steffen Rylie , Curtis Evan T. , Priester Aaron M. , Convertine Anthony J. , Kievit Forrest M. 
Published: August 2023

AbstractFollowing a traumatic brain injury (TBI), excess reactive oxygen species (ROS) and lipid peroxidation products (LPOx) are generated and lead to secondary injury beyond the primary insult. A major limitation of current treatments is poor target engagement, which has prevented success in clinical trials. Thus, nanoparticle‐based treatments have received recent attention because of their ability to increase accumulation and retention in damaged brain. Theranostic neuroprotective copolymers (NPC3) containing thiol functional groups can neutralize ROS and LPOx. Immediate administration of NPC3 following injury in a controlled cortical impact (CCI) mouse model provides a therapeutic window in reducing ROS levels at 2.08–20.83 mg kg−1 in males and 5.52–27.62 mg kg−1 in females. This NPC3‐mediated reduction in oxidative stress improves spatial learning and memory in males, while females show minimal improvement. Notably, NPC3‐mediated reduction in oxidative stress prevents the bilateral spread of necrosis in male mice, which is not observed in female mice and likely accounts for the sex‐based spatial learning and memory differences. Overall, these findings suggest sex‐based differences to oxidative stress scavenger nanoparticle treatments, and a possible upper threshold of antioxidant activity that provides therapeutic benefit in injured brain since female mice benefit from NPC3 treatment to a lesser extent than male mice.
Neutrophil‐Mediated Tumor‐Targeting Delivery System of Oncolytic Bacteria Combined with ICB for Melanoma Lung Metastasis Therapy
Authors: Liu Lina , Xin Wenjie , Li Qiang , Huang Baolian , Yin Te , Hua Siqi , Yang Chen , Chen Chen , Han Chao , Hua Zichun 
Published: August 2023

AbstractOncolytic bacteria are the most promising tumor target vector. Questions also remain regarding finding a balance between the therapeutic efficacy and safety of oncolytic bacteria. The critical measure of how this balance is maintained is the improvement in tumor colonization. Attenuated Salmonella typhimurium (VNP20009) as the only Salmonella strain to be evaluated in a clinical trial is a potential tumor therapeutic bacterium. A delivery system with controlled release of VNP after being loaded into neutrophils, which significantly increases the tumor‐targeting of VNP and enhances its therapeutic efficacy in a melanoma lung metastasis model is constructed. To improve the synergistic therapeutic effect, a PD1 nanobody is applied to this system (NE(PD1nb)). NE(PD1nb) activate dendritic cells (DCs) differentiation and stimulate the M1‐like differentiation of macrophages, and induce CD4+ T‐cells maturity and cytotoxic CD8+ T‐cells activation through DCs tumor antigen presentation.
Large‐Scale N‐Type FET and Homogeneous CMOS Inverter Array Based on Few‐Layer MoTe2
Authors: Cheng Zhixuan , Jia Xionghui , Cheng Xing , Song Yiwen , Ran Yuqia , Li Minglai , Xu Wanjin , Li Yanping , Ye Yu , Dai Lun 
Published: August 2023

Abstract2D MoTe2 is regarded as a favorable candidate for semiconductor nanoelectronics integration. Chemical‐vapor‐deposition‐grown MoTe2 usually presents p‐type characteristics. In order to realize basic electronic units like complementary metal‐oxide‐semiconductor (CMOS) inverter, controllable fabrication of p‐ and n‐type transistors at large scale is of vital importance. Here, large‐scale MoTe2 n‐channel field‐effect transistor (n‐FET) arrays are successfully fabricated with seamless coplanar metallic 1T′‐WTe2 contacts to reduce contact resistance. High‐k HfO2 serves as a gate dielectric and its atomic‐layer‐deposition (ALD) process causes an n‐doping effect on the 2H‐MoTe2 channel. The FETs perform typical n‐type characteristics with average electron density and on/off ratio of ≈1.7 × 1013 cm−2 and 2.1 × 104, respectively. Furthermore, large‐scale homogeneous CMOS inverter arrays are fabricated, showing clear logic swing with low power consumption (≈0.4 nW) and high device yield (≈92%). Notably, their voltage transfer characteristics exhibit small hysteresis, and they work well after being kept in air for 16 months, indicating high device stability. The statistical results show that both the n‐FETs and CMOS inverters have high uniformity and reliability in performance. Significantly, this fabrication method is free from transfer processes and compatible with traditional silicon technology. This work paves the way for the application of few‐layer MoTe2 in semiconductor nanoelectronics integration.
Understanding the Role of Triplet‐Triplet Annihilation in Non‐Fullerene Acceptor Organic Solar Cells
Authors: Hart Lucy J. F. , Grüne Jeannine , Liu Wei , Lau Tsz‐ki , Luke Joel , Chin Yi‐Chun , Jiang Xinyu , Zhang Huotian , Sowood Daniel J. C. , Unson Darcy M. L. , Kim Ji‐Seon , Lu Xinhui , Zou Yingping , Gao Feng , Sperlich Andreas , Dyakonov Vladimir , Yuan Jun , Gillett Alexander J. 
Published: August 2023

AbstractNon‐fullerene acceptors (NFAs) have enabled power conversion efficiencies exceeding 19% in organic solar cells (OSCs). However, the open‐circuit voltage of OSCs remains low relative to their optical gap due to excessive non‐radiative recombination, and this now limits performance. Here, an important aspect of OSC design is considered, namely management of the triplet exciton population formed after non‐geminate charge recombination. By comparing the blends PM6:Y11 and PM6:Y6, it is shown that the greater crystallinity of the NFA domains in PM6:Y11 leads to a higher rate of triplet‐triplet annihilation (TTA). This is attributed to the four times larger ground state dipole moment of Y11 versus Y6, which improves the long range NFA out‐of‐plane ordering. Since TTA converts a fraction of the non‐emissive triplet states into bright singlet states, it has the potential to reduce non‐radiative voltage losses. Through a kinetic analysis of the recombination processes under 1‐Sun illumination, a framework is provided for determining the conditions under which TTA may improve OSC performance. If these could be satisfied, TTA has the potential to reduce non‐radiative voltage losses by up to several tens of millivolts.
Highly Reversible Zinc Metal Anodes Enabled by Solvation Structure and Interface Chemistry Modulation
Authors: Wang Xiao , Feng Kaiqiang , Sang Bingyan , Li Guijin , Zhang Zhengchunyu , Zhou Guowei , Xi Baojuan , An Xuguang , Xiong Shenglin 
Published: August 2023

AbstractAqueous Zn−ion batteries (AZIBs) promise appealing advantages including safety, affordability, and high volumetric energy density. However, rampant parasitic reactions and dendrite growth result in inadequate Zn reversibility. Here, a biocompatible additive, L‐asparagine (Asp), in a low‐cost aqueous electrolyte, is introduced to address these concerns. Combining substantive verification tests and theoretical calculations, it is demonstrated that an Asp‐containing ZnSO4 electrolyte can create a robust nanostructured solid‐electrolyte interface (SEI) by simultaneously modulating the Zn2+ solvation structure and optimizing the metal‐molecule interface, which enables dense Zn deposition. The optimized electrolyte supports excellent Zn reversibility by achieving dendrite‐free Zn plating/stripping over 240 h at a high Zn utilization of 85.5% in the symmetrical cell and an average 99.6% Coulombic efficiency for over 1600 cycles in the asymmetrical cell. Adequate full‐cell performance is demonstrated with a poly(3,4‐ethylenedioxythiophene) intercalated vanadium oxide (PEDOT‐V2O5) cathode, which delivers a high areal capacity of 4.62 mAh cm−2 and holds 84.4% capacity retention over 200 cycles under practical conditions with an ultrathin Zn anode (20 µm) and a low negative/positive capacity ratio (≈2.4). This electrolyte engineering strategy provides new insights into regulating the anode/electrolyte interfacial chemistries toward high‐performance AZIBs.
Sulfur–Carbon Electrode with PEO‐LiFSI‐PVDF Composite Coating for High‐Rate and Long‐Life Lithium–Sulfur Batteries
Authors: Li Ling , Nam Jong Seok , Kim Min Soo , Wang Yifan , Jiang Shaohua , Hou Haoqing , Kim Il‐Doo 
Published: August 2023

AbstractTo address the problem of the serious capacity fading in lithium–sulfur batteries, a multi‐functional PEO(polyethylene oxide)/LiFSI (lithium bis(fluorosulfonyl)imide)/PVDF (polyvinylidene fluoride) (PLP) gel polymer electrolyte is exploited by coating PLP on a carbon nanotubes (CNTs) based sulfur cathode (PLP‐S/CNTs) with a controlled thermal annealing process. The annealing process leads to the conformal infusion of PLP through the matrix of S/CNTs with retaining the amorphous phase of the PLP, which enhance the rate performance compared to the bare S/CNTs. The PLP coating drives the transformation of more elemental sulfur to Li2S2/Li2S without forming intermediary product by restraining soluble‐polysulfides formation. Furthermore, the PLP coating successfully inhibits the dissolution of Li2Sx (x > 4) in PEO and prevents the loss of active material in the cathode, which is confirmed by density functional theory calculations. Comprehensively, the PLP coating applied to the surface of the S/CNTs cathode exhibit significantly suppressed shuttle effect and greatly improve long‐term cycle stability of the lithium–sulfur battery. The synthesized PLP‐coated S/CNTs composite cathode demonstrates a high specific capacity of 573.6 mAh g−1 at a current density of 0.5 C after 1 000 cycles, even achieving 318.1 mAh g−1 at an extremely high C‐rate (6 C). which is unprecedented performance among the reported studies on coating technology.
A Hyb‐Seq phylogeny of Boechera and related genera using a combination of Angiosperms353 and Brassicaceae‐specific bait sets
Authors: Hay Nikolai M. , Windham Michael D. , Mandáková Terezie , Lysak Martin A. , Hendriks Kasper P. , Mummenhoff Klaus , Lens Frederic , Pryer Kathleen M. , Bailey C. Donovan 
Published: August 2023

AbstractPremiseAlthough Boechera (Boechereae, Brassicaceae) has become a plant model system for both ecological genomics and evolutionary biology, all previous phylogenetic studies have had limited success in resolving species relationships within the genus. The recent effective application of sequence data from target enrichment approaches to resolve the evolutionary relationships of several other challenging plant groups prompted us to investigate their usefulness in Boechera and Boechereae.MethodsTo resolve the phylogeny of Boechera and closely related genera, we utilized the Hybpiper pipeline to analyze two combined bait sets: Angiosperms353, with broad applicability across flowering plants; and a Brassicaceae‐specific bait set designed for use in the mustard family. Relationships for 101 samples representing 81 currently recognized species were inferred from a total of 1114 low‐copy nuclear genes using both supermatrix and species coalescence methods.ResultsOur analyses resulted in a well‐resolved and highly supported phylogeny of the tribe Boechereae. Boechereae is divided into two major clades, one comprising all western North American species of Boechera, the other encompassing the eight other genera of the tribe. Our understanding of relationships within Boechera is enhanced by the recognition of three core clades that are further subdivided into robust regional species complexes.ConclusionsThis study presents the first broadly sampled, well‐resolved phylogeny for most known sexual diploid Boechera. This effort provides the foundation for a new phylogenetically informed taxonomy of Boechera that is crucial for its continued use as a model system.
Impact of extraction conditions and seed variety on the characteristics of pennycress (Thlaspi arvense) protein: a structure and function approach
Authors: Mitacek Rachel , Marks M. David , Kerr Nicole , Gallaher Daniel , Ismail Baraem P. 
Published: August 2023

AbstractAs the consumer demand for plant proteins continues to grow, the food industry is seeking novel and sustainable protein sources to incorporate in various food products. Pennycress (Thlaspi arvense), a sustainable cover crop, produces oilseeds high in protein, warranting investigation. Accordingly, protein extraction from pennycress was evaluated under various extraction conditions, using alkaline extraction and salt solubilization coupled with ultrafiltration. Given the superior color and functionality of the salt extracted pennycress protein isolate (PcPI), its production was scaled‐up about two hundred folds in a pilot plant. Furthermore, a new pennycress accession bred to have zero erucic acid (0EA) was evaluated to determine the impact of seed variety on protein characteristics. Structural and functional characterization was performed on PcPI and compared to native (nSPI) and commercial (cSPI) soy protein isolates. Salt extracted PcPI had comparable gel strength to cSPI, three times higher solubility under acidic conditions, and ~1.5 times better emulsification capacity. PcPI extracted from 0EA was mildly different in structure and functionality from that extracted from wildtype pennycress, with the slight variation attributed to genetic variance. Finally, the protein digestibility‐corrected amino acid score (PDCAAS) of the salt extracted PcPI, calculated in vivo (0.72) and in vitro (0.87), was superior or comparable to other plant protein sources. This research provided, for the first time, a comprehensive evaluation of different protein extraction protocols to produce a functional PcPI that can compete with soy protein for various food applications, such as acidic beverages, meat and dairy products, and emulsified systems.
Thermal conductivity aging and mechanical properties of polyisocyanurate (PIR) foams produced with different contents of HFO
Authors: Torres‐Regalado Patricia , Santiago‐Calvo Mercedes , Gimeno Josep , Rodríguez‐Pérez Miguel Angel 
Published: August 2023

AbstractPolyisocyanurate (PIR) foam is a thermal insulating material widely used in many industries such as construction, refrigeration, piping/tubing among others. In this research the production, characterization and modeling of the thermal conductivity of PIR foams synthesized with a hydrofluorolefin (HFO 1233zd (E)) as physical foaming agent have been studied. The results have shown that increasing the amount of HFO reduces the density, but the cellular structure is not modified. The relative mechanical properties are the same for the concentrations of HFO considered. In addition, the aging of thermal conductivity as a function of time has been studied in detail. The experimental results have been deeply analyzed using a theoretical model to predict the thermal conductivity The results show that the thermal conductivity and the rate of aging at early stages are reduced for the higher concentrations of HFO. This result has been related to the lower temperature reached during the foaming reaction for higher contents of the physical blowing agent.