bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colonization of the gastric juice by Candida spp. promotes surgical site infection after hepatectomy
Authors: Iida Hiroya , Kaibori Masaki , Maehira Hiromitsu , Mori Haruki , Nitta Nobuhito , Maekawa Takeru , Takebayashi Katsushi , Kaida Sachiko , Miyake Toru , Tani Masaji 
Published: March 2023

Abstract
Purpose: Candida spp. cause opportunistic infections in conditions of immunodeficiency. Here, we investigated the relationship between colonization of the gastric juice by Candida spp. and surgical site infection (SSI) in hepatectomy.
Methods: Consecutive hepatectomy cases between November 2019 and April 2021 were enrolled. Gastric juice samples (collected intraoperatively through a nasogastric tube) were cultured. We compared factors related to patient background, blood test findings, surgical findings, and postoperative complications between the Candida+group (positive for colonization of the gastric juice by Candida spp.) and the Candida- group (negative). In addition, we identified the factors that contribute to SSI.
Results: There were 29 and 71 patients in the Candida+ and Candida- groups, respectively. The Candida+ group was significantly older (average age: Candida+ 74 years vs. Candida- 69 years; p=0.02) and contained more patients who were negative for the hepatitis B and C virus (Candida+ 93% vs. Candida- 69%; p=0.02). SSI was significantly more common in the Candida+ group (Candida+ 31% vs. Candida- 9%; p=0.01). Postoperative bile leakage and colonization of the gastric juice by Candida spp. were independent predictors of SSI.
Conclusion: Colonization of the gastric juice by Candida spp. is a risk factor for SSI after hepatectomy.
Effects of Fe doping on preparation of Ti-Si porous membrane via in-situ reactive process
Authors: LIU Zhongjun , SU Yi , ZHAO Hui , JIAO Yanni , LEI Juan , AO Qingbo 
Published: March 2023

Abstract
Asymmetric porous filter element can reach a high filtering accuracy with larger filtration flux, which can enhance the filtration efficiency and reduce the energy consumption when it was applied in separation equipment. A novel porous material of Ti-Si intermetallic compound micro-porous membrane was successfully synthesized with Fe doped Ti mixed powder and SiO2 by the in-situ reactive sintering process. Effects of Fe doping, sintering temperature and the external load pressure on the formation of membrane were systemically studied. The results show that increasing Fe doping amount can celebrate the in-situ reactive process and promote the membrane formation. The synthesized granules on the membrane are well distributed with the size of 1∼3 µm, and the thickness of the membranes is 4∼7 µm. The relative air permeability coefficient of porous membrane reduces raptly with increasing either Fe doping amount, or sintering temperature and the external load pressure. All synthesized membranes show the presence of Ti5Si3 and Ti phases, with a little amount phase of FeTi and FeO. The membrane formation mechanism is due to the large reduction reactivity of Fe doped Ti powder with SiO2, and the asymmetric porous structure of Ti5Si3/Ti was obtained finally.
Analysis of Goldman Applanation Tonometry with and without Fluorescein among glaucomatous and non-glaucomatous patients Attending Mzuzu Central Hospital in Malawi
Authors: Munyapa Tryness , Mzumara Thokozani , Ogbonna Grace , Mvula Augastine 
Published: March 2023

Abstract
Background: Goldman Applanation Tonometry (GAT), the gold standard of tonometry, is used without fluorescein in low-resource settings. Nevertheless, corneal biomechanics differ among population groups.
Purpose: The aim of the study is to assess the relationship between GAT findings with and without fluorescein among glaucomatous and non-glaucomatous adults in Malawi.
Methods: This was a cross-sectional quantitative study involving 22 glaucoma patients and 22 non-glaucoma patients at Mzuzu Central Hospital. We used a purposive sampling technique to select participants into the two groups. Next, we measured Intraocular pressure using Goldman Applanation Tonometry with and without fluorescein. Then we entered the data into SPSS version 25. We employed the Wilcoxon test to make comparisons based on age and gender. We considered the value of p<0.05 statistically significant.
Results: There is a statistically significant and strong positive correlation between nfGAT and fGAT among both glaucoma (r = 0.989, p< 0.001) and non-glaucoma (r = 0.955, p<0.001). According to age, there is no significant difference in IOP value measured with nfGAT and fGAT for both glaucomas (p = 0.109) and non-glaucoma subjects (p = 0.076). However, significant differences were observed between nfGAT and fGAT mean IOP according to sex among both glaucomatous and non-glaucomatous subjects (p = 0.017 and p = 0.32 resp.).
Conclusion: The study suggests that the merits of intraocular pressure measured using Goldman Applanation Tonometry without fluorescein are not speculative, therefore the two techniques can be routinely used interchangeably in diagnosing and managing glaucoma.
Online conversion of reconstructed neural morphologies into standardized SWC format
Authors: Ascoli Giorgio , Mehta Ketan , Ljungquist Bengt , Ogden James , Nanda Sumit , Ascoli Ruben , Ng Lydia 
Published: March 2023

Abstract
Digital reconstructions provide an accurate and reliable way to store, share, model, quantify, and analyze neural morphology. Continuous advances in cellular labeling, tissue processing, microscopic imaging, and automated tracing catalyzed a proliferation of software applications to reconstruct neural morphology. These computer programs typically encode the data in custom file formats. The resulting format heterogeneity severely hampers the interoperability and reusability of these valuable data. Among these many alternatives, the SWC file format has emerged as a popular community choice, coalescing a rich ecosystem of related neuroinformatics resources for tracing, visualization, analysis, and simulation. This report presents a standardized specification of the SWC file format. Additionally, we introduce xyz2swc, a free online service that converts all 23 reconstruction formats (and 68 variations) described in the scientific literature into the SWC standard. The xyz2swc service is available open source through a user-friendly browser interface (https://neuromorpho.org/xyz2swc/ui/) and an Application Programming Interface (API).
Artificial Intelligence in Today’s Education Landscape: Understanding and Managing Ethical Issues for Educational Assessment
Authors: Lim Tristan , Gottipati Swapna , Cheong Michelle 
Published: March 2023

Abstract
In a societal institution as fundamental as education, when teaching practitioners or researchers apply artificial intelligence in academic processes such as assessments, it is important to study the divide between what may be ethically permissible and not permissible. This study applied a systematic literature mapping methodology to scour extant research, so as to holistically structure the landscape into explicit topical research clusters. Through topic modelling and network analyses, research mapped ten key ethical principles to five research archetypical domains, and reviewed the contribution and intensity of these ethical principles in each thematic domain. The study extended this review, by mapping out ethics programs and activities that can be applied in practice, alongside their relevant underpinning theories. This study provides a comprehensive treatment of this subject matter to date. We hope the findings of this research can provide researchers and practitioners the insights into the application methods of AI in assessments, and in particular, in terms of their intertwined ethical challenges and how these challenges may be addressed, for follow up studies.
A Novel Adipokine, Asprosin, may be a serum biomarker for breast cancer diagnosis
Authors: YUR Mesut , OZCAN Sibel , YILDIRIM Nilgun , OZDEDE Mehmet Ridvan , OZCAN Mete 
Published: March 2023

Abstract
OBJECTIVE: Breast cancer is the most common type of cancer in women. Diagnosis in early stage is very important for cancer treatment. There is no good biomarker to diagnose breast cancer in T1-2 or N0 stage. The aim of this study was to evaluate the diagnostic efficacy of asprosin as a biomarker within all stages of breast cancer.
PATIENTS AND METHODS: An enzyme-linked immunosorbent assay (ELISA) was used to evaluate serum asprosin levels in 40 patients with breast cancer and 40 healthy women. The Cancer group included T1-4, N1-3, and M0-1 patients.
RESULTS: Asprosin showed good discrimination (Area under curve (AUC) = 0.767, 95% confidence interval (CI):0.657–0.878) between breast cancer and the healthy group and acceptable discriminating ability (sensitivity = 0.825; specificity = 0.750) at the optimal cut-off value of 1.82 ng/mL. Asprosin indicated no difference for T, N, and M stages (p= 0.919, p= 0.859, and p= 0.225 respectively).
CONCLUSIONS: Asprosin may be a good diagnostic biomarker for breast cancer at all stages, regardless of T, N, and M stages. Larger prospective clinical studies are required to validate the utility of this method.
Efficacy and Safety of Concurrent Chemoradiotherapy Combined with
Nimotuzumab in Elderly Patients with Esophageal Squamous Cell Carcinoma:
A Prospective Real-world Pragmatic Study
Authors: Yu Nuo , Cheng Guowei , Li Jiao , Liang Jun , Zhang Tao , Deng Lei , Liu Wenyang , Wang Jianyang , Zhai Yirui , Wang Wenqing , Xiao Zefen , Zhou Zongmei , Chen Dongfu , Feng Qinfu , Bi Nan , Wang Xin 
Published: March 2023

Background:
Concurrent or definitive chemoradiotherapy is the standard treatment of locally
advanced esophageal squamous cell carcinoma (ESCC). Elderly patients could not tolerate the
standard concurrent chemotherapy and were treated with radiotherapy because of weak physical status
and multiple comorbidities.

Objective:
The efficacy and safety profile of concurrent (chemo) radiotherapy combined with
nimotuzumab in elderly patients with ESCC were investigated.

Methods:
Eligible elderly (≥70 years) patients with locally advanced ESCC were enrolled in this prospective,
real-world pragmatic study and received concurrent chemoradiotherapy or radiotherapy
combined with nimotuzumab. The primary endpoint was overall survival (OS). Secondary endpoints
were objective response rate, disease control rate, progression-free survival (PFS), and adverse drug
reactions.

Results:
Fifty-three elderly patients were enrolled. Thirty-two (60.4%) were treated with radiotherapy
combined with nimotuzumab (RT+N), and 21 (39.6%) with concurrent chemoradiotherapy combined
with nimotuzumab (CRT+N). The median age was 75.8 years. Fourteen (56.0%) patients achieved a
partial response, and 11 (44.0%) patients achieved stable disease at 3 months. The median follow-up
duration was 24.4 (95%CI, 21.6-26.7) months. Median OS (mOS) was 27.0 (95%CI, 14.8-48.4)
months. Median PFS (mPFS) was 22.6 (95%CI, 12.4-not reached) months. Higher mPFS (not reached
vs. 12.0 months; p=0.022) and mOS (48.4 vs. 15.3 months; p=0.009) were observed in the CRT+N
group compared with the RT+N group. Most adverse reactions were grade 1-2 (46, 86.8%).

Conclusions:
Concurrent chemoradiotherapy or radiotherapy combined with nimotuzumab was safe
and well-tolerated in elderly patients with locally advanced ESCC. ESCC patients treated with
CRT+N could live longer.
First Synthesis of 2-Bromogentisyl Alcohol from Cultures of Penicillium
Concentricum
Authors: Shan Shaojun , Lian Xiumei , Li Jingxuan , Zhong Wensen 
Published: March 2023

Abstract:
The first synthesis of 2-bromogentisyl alcohol, a halogenated compound cytotoxicity to
breast cancer cell line, was achieved in four steps. Key steps include (i) formylation of aromatic compound,
(ii) bromination, (iii) demethylation and (iv) reduction. Compound 3 was prepared from 4-
methoxyphenol (2) in 92% yield in the presence of MgCl2 and Et3N, then intermediate 4 was obtained
by bromination of 3 in 78% yield. Subsequently, the direct demethylation of 4 with BBr3 afforded the
intermediate 5 in 72% yield. Finally, title compound 1 was prepared by the reduction of 5 using
NaBH4 in 87% yield. The overall yield is 45% from 4-methoxyphenol. This method is simple and the
reaction conditions are mild.
Investigation of Airway Obstruction Severity Based on Plasma Visfatin
Level in Asthmatic Women
Authors: Fekri Mitra Samareh , Bajgani Seyed Mehdi Hashemi , Shafiepour Mohsen , Yazdani Reza , Dalfardi Behnam 
Published: March 2023

Introduction::
Bronchial asthma is a chronic disorder with high prevalence among wom-en. Visfatin as a pro-inflammatory adipokine has been linked to inflammatory lung diseases such as asthma and can be used as a forthcoming biomarker target to diagnose and treat asthmatic patients.

Aim::
The aim of this study is to evaluate plasma visfatin level and its correlation with pulmonary function of female asthmatic patients.

Methods:
This cross-sectional study was conducted on all female asthmatic patients referred to the Be'sat Pulmonary Clinic of Kerman from 1 November 2019 to 20 February 2020. Patients with con-firmed diagnosis of asthma were included. The data were collected through a checklist and the cor-responding author conducted all face-to-face interviews in the physician’s office of the pulmonary clinic. Then, blood samples (5 cc) were taken from the patients to determine the plasma level of visfatin. Data was analyzed by SPSS Software.

Results:
113 women with asthma were studied. The mean ± SD age of patients was 46.71 ± 13.91 years (range: 13 to 75). The mean ± SD of visfatin plasma levels was 26.30 ± 6.98 mg/dl (range: 8.50 to 46.88). The forced expiratory volume in the first second (FEV1) had a significant and negative correlation with plasma visfatin concentrations (P-value = 0.03).

Conclusion:
The results of this study indicated that plasma visfatin levels were correlated inversely with FEV1 among asthmatic women. Further studies with large samples are recommended to evaluate the role of visfatin in asthma pathogenesis.
Clinical and Radiographic Evaluation of Combined Acemannan and Periodontal Surgery Induced-Periodontal Regeneration: 5-Year Follow-up Case Report
Authors: Chansamart Rutchanoo , Sangvanich Polkit , Thunyakitpisal Pasutha 
Published: March 2023

Background and Objective:
Acemannan, a polysaccharide extracted from aloe vera gel, accelerates oral wound healing, reparative dentin formation, and bone formation in extraction sockets. In this report, we evaluated the efficacy of combined acemannan and periodontal surgery on periodontal regeneration in severe periodontitis cases requiring periodontal surgery.

Case Presentation and Discussion:
Three chronic periodontitis patients with probing pocket depths of at least 6 mm and two- or three-walled vertical bone defects after initial periodontal therapy were included. The patients underwent minimally invasive periodontal surgery with acemannan sponges placed in the defect. Maintenance recall was scheduled every 6 months for 5 years. Clinical and radiographic evaluations were performed to assess the effects of the combined acemannan and periodontal surgery on periodontal regeneration. The patients demonstrated improved clinical parameters and increased radiographic bone fill at the 5-year follow-ups. The percentage bone fill in the three-walled defect, combined two- and three-walled defect, and two-walled defect cases were 70%, 60%, and 20%, respectively. The underlying mechanism of action of acemannan in periodontal regeneration was also discussed.

Conclusion:
Acemannan sponges can be used as an adjunct to periodontal surgery for periodontal regeneration.
Pengaruh Model Value Clarification Technique (VCT) dalam Pembelajaran Sejarah untuk Meningkatkan Karakter Siswa SMA Negeri 1 Sungai Penuh
Authors: Ofianto Ofianto , Ningsih Tri Zahra 
Published: March 2023

<p><strong>Abstrak </strong><strong></strong></p><p class="abstrak">Penelitian ini bertujuan untuk melihat pengaruh penggunaan model <em>Value Clarification Technique</em> (VCT) dalam pembelajaran sejarah untuk meningkatkan karakter siswa SMA Negeri 1 Sungai Penuh. Metode penelitian yang digunakan adalah metode eksperimen dengan desain <em>posttest only control design.</em> Subjek penelitian adalah siswa X SMA Negeri 1 Sungai Penuh tahun pelajaran 2019/2020. Teknik pengumpulan data dilakukan dengan menggunakan lembar observasi, wawancara dan lembar kuisioner. Analisis data dilakukan dengan menggunakan <em>Statistical Package for the Social Sciences</em> (SPSS) 25.0. Temuan utama penelitian menunjukkan bahwa ada pengaruh yang signifikan penggunaan model <em>Value Clarification Technique </em>(VCT) terhadap Karaketer siswa SMA Negeri 1 Sungai Penuh. Hal ini ditunjukkan oleh nilai t -3,888 dengan signifikansi (<em>Sig)</em> sebesar 0,000 lebih kecil dari 0,05. Sehingga disimpulkan bahwa penggunaan model pembelajaran <em>Value Clarification Technique </em>(VCT) dalam pembelajaran sejarah memberikan pengaruh yang signifikan terhadap karakter peserta didik.</p><p class="abstrak"> </p><p class="abstrak"><strong>Kata Kunci: </strong><em>Value Clarification Technique </em>(VCT), Pembelajaran Sejarah, Pendidikan Karakter</p><p class="abstrak"> </p><p class="StyleAuthorBold" align="left">Abstract</p><p class="AbstractText"><em>This study aims to see the effect of using the Value Clarification Technique (VCT) model in history learning to improve the character of students of SMA Negeri 1 Sungai Penuh. The research method used was an experimental method with a posttest only control design. The research subjects were student X SMA Negeri 1 Sungai Penuh school year 2019/2020. The data collection technique is done by using observation sheets, interviews, and questionnaire sheets. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) 25.0. The main findings of the study indicate that there is a significant effect of using the Value Clarification Technique (VCT) model on the characteristics of students of SMA Negeri 1 Sungai Penuh. This is indicated by the t value of -3,888 with a significance (Sig) of 0,000, less than 0.05. So that it is concluded that the use of the Value Clarification Technique (VCT) learning model in history learning has a significant effect on the character of students.</em><em></em></p><p class="abstrak" align="left"><strong>Keywords:</strong> <em>Value Clarification Technique, History Learning, Character Building</em></p>
Penerapan Nilai-nilai Pendidikan Islam Bagi Anak (Analisis Psikologi Perkembangan Anak)
Authors: Tuti Tri Widyas , Hairiyah Hairiyah 
Published: March 2023

<strong>Abstrak: </strong>Penerapan Nilai-Nilai Pendidikan Islam Bagi Anak (Analisis Psikologi Perkembangan Anak). Penelitian ini mencoba membahas lebih dalam lagi tentang hadits yang berisi perintah shalat bagi anak HR Abu Daud, dengan analisis Psikologi Perkembangan Anak. Yakni pembahasan tentang nilai-nilai pendidikan Islam apa saja yang terkandung didalamnya, sekaligus bagaimana implikasinya bagi pendidikan anak dalam Islam.<strong> </strong>Jenis penelitian kepustakaan (<em>library research</em>) yang digunakan dalam penelitian, yakni mengumpulkan data dan informasi bermacam-macam dari perpustakaan. <em>Deskriptif-analisis</em> yang menjadi sifat penelitian<em>. </em>Pemaparan apa adanya apa yang dimaksud dalam teks dengan cara memfrasekan. Sedangkan data diolah dengan <em>content analysis. </em>Adapun nilai-nilai pendidikan Islam yang dapat diambil kemudian diterapkan ialah, Nilai Pendidikan Keimanan, Nilai Pendidikan Ibadah., Metode Mendidik Anak dengan <em>Tarhib </em>dan Nilai Pendidikan Seks Bagi Anak. Penerapannya adalah<strong> </strong>ke empat nilai tersebut dapat menjadi alat pengubah anak melalui proses pendidikan, Pedoman pengabdian seorang hamba kepada Tuhannya, membentuk manusia yang bertaqwa melalui ibadah mahdhah dan ghairu mahdhah. Selain itu dilibatkan dalam proses pendidikan di lingkungan keluarga, sekolah dan masyarakat.<strong></strong><p><strong><em>Kata kunci</em></strong><em> : Nilai, Pendidikan Islam, Anak, Psikologi Perkembangan</em></p>
Penerapan Model Pembelajaran Kooperatif Tipe Numbered Head Together (NHT) Untuk Meningkatkan Hasil Belajar Matematika Kelas VII Siswa MTS Amalul Ikhlas T.A. 2019/2020
Authors: Adawiya Robiatul 
Published: March 2023

<p>Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar Matematika siswa pada materi Himpunan di kelas VII MTs Amalul Ikhlas dengan menerapkan metode pembelajaran Model Pembelajaran Kooperatif Tipe <em>Numbered Head Together</em> (NHT). Penelitian tindakan kelas ini dilakukan 2 Siklus yang meliputi kegiatan perencanaan, pelaksanaan, observasi, wawancara dan refleksi. Sedangkan untuk mengetahui kemampuan siswa, peneliti menggunakan tes hasil belajar siswa secara individu.</p><p> Yang menjadi subjek dalam penelitian ini adalah siswa kelas VII MTs Amalul Ikhlas yang berjumlah 25 orang siswa yang terdiri dari 8 siswa laki- laki dan 17 siswi perempuan. Dari hasil penelitian dapat dilihat hasil tes awal (pre-tes) persentase kelulusan klasikalnya diperoleh 16.00% (4 siswa). Setelah pemberian tindakan pengajaran melalui metode pembelajaran Kooperatif Tipe <em>Numbered Head Together</em> (NHT), tes hasil belajar siswa pada Siklus I persentase ketuntasan klasikal diperoleh 44.00% (11 siswa). Sedangkan setelah dilakukan perbaikan pada Siklus II diperoleh tes hasil belajar II persentase ketuntasan klasikal sebesar 88.00% (22 siswa).</p><p> Dari hasil penelitian tindakan kelas ini maka peneliti menyimpulkan adanya peningkatan hasil belajar Matematika siswa pada materi Himpunan sebesar 44.00%.dengan menerapkan metode pembelajaran Kooperatif Tipe <em>Numbered Head Together</em> (NHT) dan merekomendasi pada pelaksana pembelajaran untuk mengajarkan materi dengan mengembangkan metode pembelajaran Kooperatif Tipe <em>Numbered Head Together</em> (NHT).</p><p> </p><p><strong>Kata kunci</strong> :</p><p>Hasil Belajar Materi Himpunan, Model Pembelajaran Kooperatif Tipe <em>Numbered Head Together</em> (NHT).</p>
Optimal injection rate and catheter size for brain perfusion computed tomography using non-ionic contrast medium in clinically normal Beagles
Authors: Choi Wonyoung , Ko Jaeun , Kim Jayon , Cho Chang-hyeon , Kim Jaehwan , Eom Kidong 
Published: March 2023

Abstract

OBJECTIVE
To evaluate the effects of contrast medium injection rates and intravenous injection catheter sizes on the time-density curve (TDC) of brain perfusion computed tomography (PCT) images in clinically normal Beagles and provide a reference range for the perfusion parameters for clinical application of PCT in veterinary medicine.

ANIMALS
5 healthy, sexually intact male Beagles.

PROCEDURES
All dogs underwent general anesthesia for PCT. Contrast medium (350 mg I/kg) was injected at 3 different injection rates (2, 3, and 4 mL/second) and with 2 sizes of an intravenous catheter (20-gauge and 24-gauge). The rostral cerebral artery and dorsal sagittal sinus were selected as the regions of interest of the TDC. Initiation time of arterial inflow (ta), venous outflow (tv), peak time of arterial enhancement (Tap), and the peak time of venous enhancement (Tvp), were measured, and the difference between Tap and tv (Tap-tv) and between Tap and ta (Tap-ta) was calculated.

RESULTS
Both Tap-tv and Tap-ta were significantly (P < .05) shorter at the rate of 3 mL/second than at 2 mL/second with the 24-gauge catheter. However, there was no significant difference according to catheter sizes. Particularly, a 4 mL/second injection rate using a 24-gauge catheter mostly resulted in contrast medium leakage and catheter rupture.

CLINICAL RELEVANCE: CONTRAST MEDIUM INJECTION
At a rate of 3 mL/second and with a 24-gauge catheter ensures optimal image acquisition and stable contrast medium injection in brain PCT for small dogs. PCT may be useful for diagnosing cerebrovascular events and hemodynamic changes in small dogs.