bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel splicing variation in L1CAM is responsible for recurrent fetal hydrocephalus
Authors: He Tiantian , Yao Qiang , Xu Bocheng , Yang Mei , Jiang Jieni , Xiang Qingqing , Xiao Like , Liu Shanling , Wang He , Zhang Xuemei 
Published: July 2023

AbstractBackgroundThe L1 cell adhesion molecule (L1CAM, OMIM 308840) gene is primarily expressed in the nervous system and encodes the L1 adhesion molecule protein. Variations in L1CAM cause a wide spectrum of X‐linked neurological disorders summarized as the L1 syndrome.MethodsWe report a 29‐year‐old pregnant woman who experienced multiple adverse pregnancy outcomes due to recurrent fetal hydrocephalus with an X‐linked recessive inheritance. Genomic DNA was extracted from the third aborted male fetus and analyzed via trio whole‐exome sequencing (WES). Total RNA was isolated from the pregnant woman to assess splicing variation at the mRNA level, and amniotic fluid was extracted from the woman for prenatal diagnosis on her fourth fetus.ResultsAll four male fetuses were affected by severe hydrocephalus. We identified a maternally derived hemizygous splicing variation NM_000425.5:[c.3046 + 1G > A]; NP_000416.1 p.(Gly1016AspfsTer6) (chrX:153130275) in Intron 22 of the L1CAM. This variation disrupts the donor splice site and causes the retention of Intron 22, which results in frame shift and a premature termination codon at position 1021 with the ability to produce a truncated protein without the fifth fibronectin‐repeat III, transmembrane, and cytoplasmic domains or to induce the degradation of mRNAs by nonsense‐mediated mRNA decay. The same hemizygous variant was also detected in the amniocytes.ConclusionThis report enhances our knowledge of genetic and phenotypic characteristics of X‐linked fetal hydrocephalus, providing a new genetic basis for prenatal diagnosis and pre‐implantation prenatal diagnosis.
Phenothiazine‐based virtual screening, molecular docking, and molecular dynamics of new trypanothione reductase inhibitors of Trypanosoma cruzi
Authors: González‐González Alonzo , Vázquez Citlali , Encalada Rusely , Saavedra Emma , Vázquez‐Jiménez Lenci K. , Ortiz‐Pérez Eyra , Bolognesi María Laura , Rivera Gildardo 
Published: July 2023

AbstractPhenothiazine derivatives can unselectively inhibit the trypanothione‐dependent antioxidant system enzyme trypanothione reductase (TR). A virtual screening of 2163 phenothiazine derivatives from the ZINC15 and PubChem databases docked on the active site of T. cruzi TR showed that 285 compounds have higher affinity than the natural ligand trypanothione disulfide. 244 compounds showed higher affinity toward the parasite's enzyme than to its human homolog glutathione reductase. Protein‐ligand interaction profiling predicted that the main interactions for the top scored compounds were with residues important for trypanothione disulfide binding: Phe396, Pro398, Leu399, His461, Glu466, and Glu467, particularly His461, which participates in catalysis. Two compounds with the desired profiles, ZINC1033681 (Zn_C687) and ZINC10213096 (Zn_C216), decreased parasite growth by 20 % and 50 %, respectively. They behaved as mixed‐type inhibitors of recombinant TR, with Ki values of 59 and 47 μM, respectively. This study provides a further understanding of the potential of phenothiazine derivatives as TR inhibitors.
Optimum design of planar quasi‐Yagi antenna for wearable Internet of Things (IoT) applications
Authors: Dass Ruby , Thirumoorthy Gopalakrishnan , Ananthakrishnan Gayathri , Kannan Anusha , Rajendran Sureshbabu , Narayanan Manikandan , Arputharaj Kannan 
Published: July 2023

AbstractThis paper presents the design of a novel dual‐band quasi‐Yagi antenna for on‐body communications. The proposed antenna is designed on 0.05 mm thin microwave laminate and is designed to cover the 2.45 and 3.5 GHz spectrum to meet the needs of on‐body Internet of Things networks. Microstrip to slot‐line transition is used for the excitation of the feeder element. The conventional feeder of the quai‐Yagi is replaced with F‐shaped radiators to obtain a dual‐band response. In addition, a pair of directors are used to enhance the antenna gain. The proposed quasi‐Yagi antenna is optimized using the spider monkey algorithm. The chosen algorithm is used to synthesize the dimensions of the dual‐band radiator and is preferred to obtain quick convergence, unlike the traditional optimization algorithms. The optimized planar quasi antenna offers 5% bandwidth in both operating bands with a measured gain of 5.7 and 5.8 dBi, respectively. The optimization time is also considerably reduced in comparison with traditional optimization algorithms. The simulated and optimized antenna is fabricated and tested.
Preprocessing for segment routing optimization
Authors: Callebaut Hugo , De Boeck Jérôme , Fortz Bernard 
Published: July 2023

AbstractIn this article we introduce a preprocessing technique to solve the Segment Routing Traffic Engineering Problem optimally using significantly fewer computational resources than previously introduced methods. Segment routing is a recently developed interior gateway routing protocol to be used on top of existing protocols that introduces more flexibility in traffic engineering. In practice, segment routing allows to deviate traffic from its original path by specifying a list of intermediate nodes or links, called segments, to visit before going to its destination. The issue we tackle in this article is that the number of segment paths scales exponentially with the maximum number of segments allowed leading to scalability issues in mathematical formulations. This article introduces the notion of dominated segment paths, these are paths that can be eliminated from the solution space when searching for an optimal solution. We propose a dynamic programming algorithm eliminating dominated paths for any number of segments. Numerical results show that respectively 50%, 90%, and 97% of paths are dominated when considering up to 2, 3, and 4 segments on benchmark network topologies.
How does the use of a recycled polypropylene matrix influence the performance of flax/polypropylene composites compared to a virgin matrix?
Authors: Mattlet Agnès , Sicot Olivier , Aivazzadeh Shahram , Catania Florian , van Schoors Laetitia 
Published: July 2023

AbstractWhen manufacturing unidirectional flax/thermoplastic composites by thermocompression, the intrinsic characteristics of the matrix can potentially influence the properties of the composite. The objective of this study is to determine the impact of recycled matrix on the performance of flax/MAPP/PP composite. In this work, three PP matrices, one virgin and two recycled, were used in the manufacture of flax/MAPP/PP composites. By a multi‐scale analysis of the three PP matrices, their characteristics influencing the quality of the composite could be identified. It appears that the length of the polymer chains changes the quality of the interface as a short chain length leads to poor entanglement of PP with MAPP. Additionally, high viscosity lowered dispersion of fiber bundles, however it could be corrected by modifying the process pressure. Finally, the presence of a small amount of PE, as is common in recycled PP, has no significant effect on the mechanical properties of composites.
Co‐crystallization behaviors and thermo‐physical properties of SSPCM consisting of an extra low melt viscosity HDPE and paraffin waxes
Authors: Mu Mulan 
Published: July 2023

AbstractShape stabilized phase change materials (SSPCMs) consisting of an extra low melt viscosity high‐density polyethylene (lv‐HDPE) and paraffin waxes (PW) were fabricated using a twin screw extruder. Thermal and mechanical properties of these composites were assessed. The latent heats (ΔH) of the SSPCMs fabricated were up to 78 J g−1. Co‐crystallization between lv‐HDPE and paraffin waxes increased with increasing wax content. Dynamic mechanical thermal analysis confirmed the paraffin wax having a higher melting point (H‐PW, Tm ranging from 56 to 58°C) plasticized the lv‐HDPE, decreasing both its crystalline content and melting temperature. Static mechanical testing, disregarding the form of deformation (tension, flexural, and compression), showed addition of paraffin waxes resulted in a diminution of all mechanical properties of lv‐HDPE, but the properties of the composites with H‐PW were good in comparison to those with a lower melting point wax (L‐PW, Tm ranging from 18 to 23°C). Evidences from Cole–Cole plots obtained from oscillatory rheology experiments showed there was no interaction between lv‐HDPE and H‐PW, inducing a heterogeneous blend in contrast to the more homogeneous lv‐HDPE/L‐PW composites.
A novel strategy for preparing ethylene‐vinyl acetate composites with high effective flame retardant and smoke suppression performance by incorporating piperazine pyrophosphate and Ce‐MOF
Authors: Jiang Siyu , Li Sheng , Yang Xuhui , Liu Lubin , Li Xiaoli , Xu Miaojun 
Published: July 2023

AbstractCerium‐containing metal organic framework defined as Ce‐MOF was prepared and then combined with piperazine pyrophosphate (PAPP) for preparing flame retardant ethylene vinyl acetate (EVA) copolymer composites. The samples of EVA/PAPP/Ce‐MOF achieved UL‐94 V‐0 rating with the limiting oxygen index (LOI) value of 31.3% when 17 wt% PAPP/Ce‐MOF with the mass fraction of 97:3 was introduced. Under the same loading amount of PAPP, the EVA/PAPP only obtained UL‐94 V‐1 rating with the LOI value of 26.9%. Cone calorimeter test confirmed that the total heat release and total smoke production of EVA/PAPP/Ce‐MOF significantly reduced from 132.8 MJ m−2 and 11.5 m2 for EVA/PAPP to 98.8 MJ m−2 and 7.3 m2, with a reduction of 25.6% and 36.5%, respectively. Besides, the maximum smoke density decreased from 488.8 and 375.9 for EVA and EVA/PAPP to 177.5 for EVA/PAPP/Ce‐MOF. It indicated that the addition of Ce‐MOF and PAPP effectively exerted synergistic flame retardant and smoke inhibition effect for EVA. Moreover, the addition of Ce‐MOF enhanced the compatibility of PAPP with EVA matrix, and water resistance of EVA/PAPP/Ce‐MOF was higher than that of EVA/PAPP. The x‐ray photoelectron spectroscopy texts of residual char of EVA composites indicated that the cerium ion complexed with phosphoric acid and polyphosphate generated by the thermal decomposition of PAPP and then more phosphorus elements remained in condensed phase. As a result, the sufficient, crosslinking and dense char layer with excellent intensity was formed, and the heat, combustible gas and smoke were efficiently inhibited. Consequently, the EVA materials were endowed excellent fire safety as well as low heat and smoke release.
Macroporous fibers electrospun from dual‐good solvent system
Authors: Chen Fang‐Ting , Chang Kai‐Pin , Liao Yi‐Cheng , Tung Shih‐Huang 
Published: July 2023

AbstractThe polymer/solvent/nonsolvent ternary solutions have been previously used for fabricating electrospun macroporous fibers, in which the nonsolvent was expected to induce a liquid–liquid phase separation that leads to formation of pores after drying. In this study, we demonstrate that the poly(styrene‐co‐acrylonitrile) (SAN)/chlorobenzene (CB)/dimethyl sulfoxide (DMSO) system can be successfully electrospun into highly uniform macroporous fibers with pore size >50 nm at CB/DMSO volume ratio ~7/3 though both CB and DMSO are good solvents to SAN. The results imply that a premixed nonsolvent is not necessary for the formation of macropores. We find that it is the water droplets condensed from the atmosphere that work as the nucleation sites to trigger the phase separation while water‐miscible DMSO plays a supporting role to expand the solvent‐rich phase and the resultant pore size. Instead of solvent quality, the distinct volatilities and water miscibilities of the solvents are the keys. The macropores throughout the fibers provide high surface areas and large openings on surface such that the fibers show a significant improvement in oil adsorption capacity in comparison to the smooth and mesoporous ones.
ConquerFear‐Group: A randomized controlled trial of an online‐delivered group‐based psychological intervention for fear of cancer recurrence in breast cancer survivors
Authors: Tauber Nina M. , O’Toole Mia S. , Jensen Anders B. , Butow Phyllis N. , Thewes Belinda , Elkjær Emma , Knutzen Sofie , von Heymann Annika , Johansen Christoffer , Zachariae Robert 
Published: July 2023

AbstractObjectiveFear of cancer recurrence (FCR) is a distressing concern among cancer survivors. Interventions to address FCR need to be effective but also accessible and low cost. This randomized controlled trial evaluated the efficacy of an online group‐based psychological intervention for FCR (ConquerFear‐Group).MethodsEligible breast cancer (BC) survivors had completed primary treatment 3 months–5 years previously, were ≥18 years, and scored ≥22 on the Fear of Cancer Recurrence Inventory–Short Form (FCRI‐SF). Participants were randomized to online ConquerFear‐Group (focusing on metacognitive strategies, values‐clarification, and education about follow‐up behavior) or online group‐based relaxation training (active control). Questionnaires were completed at baseline (T1), 1 week post‐intervention (T2), three (T3) and six (T4) months later. The primary outcome was FCR (FCRI total). A number of secondary and process outcomes were also collected. Treatment effects were evaluated with mixed linear models.ResultsOf 866 eligible BC survivors, 475 (55%) completed the FCR screening, and 85 (18%) were randomized to ConquerFear‐Group or relaxation training (2 × 6 groups). Compared with control participants, ConquerFear‐Group participants experienced larger reductions in FCR (Cohen's d = 0.47, p = 0.001) and FCR severity (d = 0.57, p < 0.001), as well as mindfulness and decentering from baseline through follow‐up, and improvements in emotion regulation (T2), worry (T2, T3) and rumination (T2) at some time points.ConclusionsThe results demonstrated statistically significant and stable effects of ConquerFear‐Group on FCR that were maintained over a 6‐month period. It is suggested to investigate the program in a real‐life setting, where a pragmatic trial can further demonstrate feasibility and effectiveness.
The brown planthopper NlDHRS11 is involved in the detoxification of rice secondary compounds
Authors: Yang Jun , Yan Shu‐Ying , Li Guo‐Cheng , Guo Hao , Tang Rui , Ma Ruiyan , Cai Qing‐Nian 
Published: July 2023

AbstractBACKGROUNDThe brown planthopper (Nilaparvata lugens, BPH) is the most destructive serious pest in rice production. Resistant varieties are effective means to defend against BPH, but the impact of the ingestion of resistant rice on BPH transcriptional regulation is still unclear. Here, we explore the molecular basis of the regulation by BPH feeding on resistant rice.RESULTSBPH nymphs preferentially selected susceptible rice TN1 at 24 h after release in a choice test. Feeding on resistant rice IR56 under nonselective conditions increased mortality, decreased growth rate, and prolonged the molting time of BPH. Transcriptomic sequencing revealed 38 dysregulated genes, including 31 down‐regulated and seven up‐regulated genes in BPH feeding on resistant rice for 7 days compared with feeding on susceptible rice TN1. These genes were mainly involved in the pathways of growth and development, metabolism, energy synthesis, and transport. Finally, we showed that the toxicities of rice defensive compounds to BPH were dose‐dependent, and silencing of the BPH gene dehydrogenase/reductase SDR family member 11 (NlDHRS11) increased sensibility to the rice secondary compounds ferulic acid and resorcinol.CONCLUSIONThe adaption of BPH feeding on resistant rice is orchestrated by dynamically regulating gene expressions, and NlDHRS11 is a gene involved in the detoxification of plant defensive chemicals. The current work provides new insights into the interaction between insects and plants, and will help to develop novel BPH control strategies. © 2023 Society of Chemical Industry.
Effect of soil organic matter on sorption of water vapor and associated hysteresis
Authors: Song Xue , Chen Chong , Arthur Emmanuel , Tuller Markus , Zhou Hu , Shang Jianying , Hu Kelin 
Published: July 2023

AbstractIn‐depth knowledge about the impact of organic matter (OM) on soil water vapor sorption (SWVS) and associated hysteresis related to various water activity (aw) levels is limited. The objective of this study was to elucidate the effect of OM on SWVS and sorption hysteresis for different aw levels. We measured water sorption isotherms and physicochemical properties of eight soils with varying clay (6%–47%) and OM (2.0%–7.8%) contents before and after OM removal. In general, OM increased SWVS, but the effect of OM on SWVS varied for different aw ranges. The presence of OM generally increased water vapor sorption during the adsorption process. For soils with OM content above 4.6%, the presence of OM decreased water vapor sorption during the condensation process. The local hysteresis (Hw) of soils with OM was higher than that of soils without OM for soils with OM contents above 3.4%. For aw < ∼0.75, the water vapor sorption hysteresis of soils with and without OM showed a significant correlation with cation exchange capacity (CEC), and the Hw values of soils with OM were lower than that of soils without OM for the same CEC. The OM can affect water vapor sorption and the associated hysteresis at low aw levels through adsorbed cations and organic functional groups, and at high aw levels through the structures of pores and OM.
Community resilience implications for institutional response under uncertainty: Cases of the floods in Wayanad, India and the earthquake in Port‐au‐Prince, Haiti
Authors: Koshy Mrudhula , Smith David 
Published: July 2023

AbstractWhile trajectories of community resourcefulness, solidarity, and mutual trust during and following environmental crises are abound in the literature, how these trajectories are taken into consideration and influences spatial planners, humanitarians and decision makers working under uncertainty remains under documented. Our article explores the concept of community resilience in action to illustrate where community resilience in action is supported, hindered or ignored by the state and non‐state organizations. Through an inductive epistemological approach, it draws examples from the exploratory fieldwork of two case studies and interviews in settlements in developmental contexts where the inhabitants, built environments and livelihoods have been severely affected following a hazardous event. Using observations and testimonies from Wayanad, a hill district in India affected by heavy monsoon floods in 2018 and 2019, and from marketplaces in Port‐au‐Prince, Haiti, following the 2010 earthquake, the article discusses how understandings of community resilience in action in post‐disaster developmental contexts could contribute to enhancing institutional responses under uncertainty.
A first principles study on the catalytic performance of methylcyclohexane dehydrogenation on a monoatomic catalyst
Authors: Zulaehah Siti , Saputra Eqwar , Jonuarti Riri , Cahyanto Wahyu Tri 
Published: July 2023

SummaryThis research explores how methylcyclohexane (MCH) interacts with individual metal atoms M (M= Pt, Pd, and Cu) based on density functional theory (DFT) total energy calculations. We analyzed the adsorption energies of MCH on these metal atoms to understand their stability and reactivity. The results show that MCH prefers to attach to single Pt atoms, which exhibited the strongest adsorption energy. Compared with Pt(111) surfaces, the adsorption energies on Pt atoms were slightly higher, indicating enhanced stability at the nanoscale. Adsorption on Pd and Cu atoms resulted in lower adsorption energies than on Pt. We also focused on the initial step of dehydrogenation, where we studied the removal of one hydrogen atom (H1) from MCH. The presence of a single metal atom significantly lowered the energy required for breaking the C1–H1 bond, with Pt showing the lowest energy barrier compared with Pd and Cu due to the excessive of charge transfer. We analyzed the electronic properties and charge transfer during dehydrogenation, revealing the influence of the metal atom's electronic structure on catalytic behavior. Overall, this research provides valuable insights into how MCH interacts with monoatomic metal catalysts, emphasizing the role of the metal atom's electronic configuration in determining reactivity.
Boron Dopant Modulated Electron Localization of Tin Oxide for Efficient Electrochemical CO2 Reduction to Formate
Authors: Zhong Xiaohui , Yang Tingting , Liang Shujie , Zhong Zuqi , Deng Hong 
Published: July 2023

AbstractSn‐based electrocatalysts have great economic potential in the reduction of CO2 to HCOOH, while they still suffer from low current density, dissatisfactory selectivity, and poor stability. Inspired by electronic modification engineering, boron‐doped SnO2 nanospheres (B‐SnO2) are successfully synthesized to achieve high‐efficiency CO2 reduction reaction (CO2RR). It is found that the introduction of boron dopants can increase the number of active sites and facilitate the formation of the electron‐rich Sn sites in its structure, thus enhancing the activation of CO2 molecules and reducing the energy barrier of *OCHO intermediates on the SnO2 surface. Thus, the B‐doped SnO2 electrocatalyst exhibits a remarkable FEHCOOH above 90% within a broad potential window of −0.7 to −1.3 V versus reversible hydrogen electrode (RHE) (600 mV) and obtains the maximum value of 95.1% (the partial current density of HCOOH is 42.35 mA cm−2) at −1 V versus RHE. In conclusion, this work provides a novel strategy for optimizing the intrinsic properties of electrocatalysts for CO2RR by the method of tuning the electronic structure.
Trapping Halogen Anions in Cationic Viologen Porous Organic Polymers for Highly Cycling‐Stable Cathode Materials
Authors: Wang Zhaolei , Qi Qiaoyan , Jin Weize , Zhao Xin , Huang Xiaoyu , Li Yongjun 
Published: July 2023

AbstractHalogens, especially Br2 and I2, as cathode materials for lithium‐ion batteries exhibit high energy density with low cost, but poor cycling performance due to their high solubility in electrolyte solution. Herein, viologen‐based cationic porous organic polymers (TpVXs, X = Cl, Br, or I) with abundant pores and ionic redox‐active moieties are designed to immobilize halogen anions stoichiometrically. TpVBr and TpVI electrodes exhibit high initial specific capacity (116 and 132 mAh g−1 at 0.2 C) and high average discharge voltage (≈3.0 V) without any host materials. Notably, benefiting from the porous and ionic structure, TpVBr and TpVI present excellent long‐term cycling stability (86% and 98% capacity retention after 600 cycles at 0.5 C), which are far superior to those of the state‐of‐the‐art halogen electrodes. In addition, the charge storage mechanism is investigated by in situ Raman and ex situ X‐ray photoelectron spectroscopy.