bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in upper airways microbiota in ventilator-associated pneumonia
Authors: Alagna Laura , Mancabelli Leonardo , Magni Federico , Chatenoud Liliane , Bassi Gabriele , Del Bianco Silvia , Fumagalli Roberto , Turroni Francesca , Mangioni Davide , Migliorino Guglielmo M. , Milani Christian , Muscatello Antonio , Nattino Giovanni , Picetti Edoardo , Pinciroli Riccardo , Rossi Sandra , Tonetti Tommaso , Vargiolu Alessia , Bandera Alessandra , Ventura Marco , Citerio Giuseppe , Gori Andrea 
Published: March 2023

Abstract
Background
The role of upper airways microbiota and its association with ventilator-associated pneumonia (VAP) development in mechanically ventilated (MV) patients is unclear. Taking advantage of data collected in a prospective study aimed to assess the composition and over-time variation of upper airway microbiota in patients MV for non-pulmonary reasons, we describe upper airway microbiota characteristics among VAP and NO-VAP patients.

Methods
Exploratory analysis of data collected in a prospective observational study on patients intubated for non-pulmonary conditions. Microbiota analysis (trough 16S-rRNA gene profiling) was performed on endotracheal aspirates (at intubation, T0, and after 72 h, T3) of patients with VAP (cases cohort) and a subgroup of NO-VAP patients (control cohort, matched according to total intubation time).

Results
Samples from 13 VAP patients and 22 NO-VAP matched controls were analyzed. At intubation (T0), patients with VAP revealed a significantly lower microbial complexity of the microbiota of the upper airways compared to NO-VAP controls (alpha diversity index of 84 ± 37 and 160 ± 102, in VAP and NO_VAP group, respectively, p-value < 0.012). Furthermore, an overall decrease in microbial diversity was observed in both groups at T3 as compared to T0. At T3, a loss of some genera (Prevotella 7, Fusobacterium, Neisseria, Escherichia–Shigella and Haemophilus) was found in VAP patients. In contrast, eight genera belonging to the Bacteroidetes, Firmicutes and Fusobacteria phyla was predominant in this group. However, it is unclear whether VAP caused dysbiosis or dysbiosis caused VAP.

Conclusions
In a small sample size of intubated patients, microbial diversity at intubation was less in patients with VAP compared to patients without VAP.
Near-real-time estimation of fossil fuel CO2 emissions from China based on atmospheric observations on Hateruma and Yonaguni Islands, Japan
Authors: Tohjima Yasunori , Niwa Yosuke , Patra Prabir K. , Mukai Hitoshi , Machida Toshinobu , Sasakawa Motoki , Tsuboi Kazuhiro , Saito Kazuyuki , Ito Akihiko 
Published: March 2023

AbstractWe developed a near-real-time estimation method for temporal changes in fossil fuel CO2(FFCO2) emissions from China for 3 months [January, February, March (JFM)] based on atmospheric CO2and CH4observations on Hateruma Island (HAT, 24.06° N, 123.81° E) and Yonaguni Island (YON, 24.47° N, 123.01° E), Japan. These two remote islands are in the downwind region of continental East Asia during winter because of the East Asian monsoon. Previous studies have revealed that monthly averages of synoptic-scale variability ratios of atmospheric CO2and CH4(ΔCO2/ΔCH4) observed at HAT and YON in JFM are sensitive to changes in continental emissions. From the analysis based on an atmospheric transport model with all components of CO2and CH4fluxes, we found that the ΔCO2/ΔCH4ratio was linearly related to the FFCO2/CH4emission ratio in China because calculating the variability ratio canceled out the transport influences. Using the simulated linear relationship, we converted the observed ΔCO2/ΔCH4ratios into FFCO2/CH4emission ratios in China. The change rates of the emission ratios for 2020–2022 were calculated relative to those for the preceding 9-year period (2011–2019), during which relatively stable ΔCO2/ΔCH4ratios were observed. These changes in the emission ratios can be read as FFCO2emission changes under the assumption of no interannual variations in CH4emissions and biospheric CO2fluxes for JFM. The resulting average changes in the FFCO2emissions in January, February, and March 2020 were 17 ± 8%, − 36 ± 7%, and − 12 ± 8%, respectively, (− 10 ± 9% for JFM overall) relative to 2011–2019. These results were generally consistent with previous estimates. The emission changes for January, February, and March were 18 ± 8%, − 2 ± 10%, and 29 ± 12%, respectively, in 2021 (15 ± 10% for JFM overall) and 20 ± 9%, − 3 ± 10%, and − 10 ± 9%, respectively, in 2022 (2 ± 9% for JFM overall). These results suggest that the FFCO2emissions from China rebounded to the normal level or set a new high record in early 2021 after a reduction during the COVID-19 lockdown. In addition, the estimated reduction in March 2022 might be attributed to the influence of a new wave of COVID-19 infections in Shanghai.
A model-free approach to do long-term volatility forecasting and its variants
Authors: Wu Kejin , Karmakar Sayar 
Published: March 2023

AbstractVolatility forecasting is important in financial econometrics and is mainly based on the application of various GARCH-type models. However, it is difficult to choose a specific GARCH model that works uniformly well across datasets, and the traditional methods are unstable when dealing with highly volatile or short-sized datasets. The newly proposed normalizing and variance stabilizing (NoVaS) method is a more robust and accurate prediction technique that can help with such datasets. This model-free method was originally developed by taking advantage of an inverse transformation based on the frame of the ARCH model. In this study, we conduct extensive empirical and simulation analyses to investigate whether it provides higher-quality long-term volatility forecasting than standard GARCH models. Specifically, we found this advantage to be more prominent with short and volatile data. Next, we propose a variant of the NoVaS method that possesses a more complete form and generally outperforms the current state-of-the-art NoVaS method. The uniformly superior performance of NoVaS-type methods encourages their wide application in volatility forecasting. Our analyses also highlight the flexibility of the NoVaS idea that allows the exploration of other model structures to improve existing models or solve specific prediction problems.
Microperimetric analysis of diabetic macular edema after navigated direct photocoagulation with short-pulse laser for microaneurysms
Authors: Ikegami Yasuko , Shiraya Tomoyasu , Araki Fumiyuki , Ueta Takashi , Toyama Taku , Yanagita Tomohiko , Numaga Jiro , Shoji Nobuyuki , Kato Satoshi 
Published: March 2023

Abstract
Background
Focal laser photocoagulation is an important treatment option for diabetic macular edema (DME). This study aimed to examine the retinal sensitivity (RS) and morphological changes at the coagulated site after direct photocoagulation of microaneurysms (MAs) in patients with DME using a navigated laser photocoagulator with a short-pulse duration of 30 ms.

Methods
Images of early-phase fluorescein angiography were merged with images from the optical coherence tomography (OCT) map with 9 Early Treatment Diabetic Retinopathy Study grid circles, and MAs inside the edema area were selected for direct photocoagulation. The best-corrected visual acuity (BCVA), parameters of the OCT map including central retinal thickness and retinal thickness in edema range, central RS, and RS in the edema area were assessed at 1 and 3 months after the laser treatment. The RS points that overlapped with the laser spots were identified by merging the Navilas’ digital treatment reports and the microperimetry images.

Results
Seventeen eyes from 14 patients were studied. The mean retinal thickness in the edema range decreased at 3 months compared with pretreatment (P = 0.042), but the BCVA, central retinal thickness, central RS, and RS in the edema area remained unchanged. Overall, 32 of 400 sensitivity points overlapped with the laser-coagulated spots. The mean RS at these spots were 22.4 ± 5.3 dB at 1 month and 22.5 ± 4.8 dB at 3 months, with no significant change from the baseline of 22.7 ± 3.5 dB.

Conclusions
Retinal thickness improved in the coagulated edema area without a decrease in RS after direct photocoagulation of MAs with a short 30-ms pulse using Navilas. This promising therapeutic strategy for DME is effective and minimally invasive.
Physical activity and sedentary behaviour of male adolescents in Indonesia during the COVID-19 pandemic: a mixed-method case study using accelerometers, automated wearable cameras, diaries, and interviews
Authors: Andriyani Fitria Dwi , De Cocker Katrien , Priambadha Aprida Agung , Biddle Stuart J. H. 
Published: March 2023

Abstract
Background
Previous physical activity and sedentary behaviour studies during the pandemic have largely utilized online surveys, with known limitations including recall bias. Employing both device-based and self-reported measurements may provide a more comprehensive picture of both behaviours. Physical activity and sedentary behaviour research in adolescents is still limited in low- and middle-income countries (LMICs), including Indonesia. Male adolescents had been identified as more active than females but have had a greater decrease in physical activity during the pandemic. The present study aimed to investigate the quantity, temporal patterns, contexts, and biopsychosocial factors of physical activity and sedentary behaviour during the COVID-19 pandemic in a small group of male Indonesian adolescents.

Methods
Male adolescents (n = 5; 14–15 years old) from Yogyakarta wore accelerometers and automated wearable cameras for four days, and completed diaries and interviews in November 2020.

Results
Participants’ activity was dominated by light intensity (67% of all physical activity). Sedentary behaviour was high; accelerometer, school days: 456 ± 145 min (78 ± 10% of wear time), non-school days: 344 ± 160 min (79 ± 17% of wear time); camera, school days: 176 ± 101 min (81 ± 46% of wear time), non-school days: 210 ± 165 min (86 ± 67% of wear time). Sedentary behaviour was mainly done during school hours on school days and from late afternoon to evening on non-school days. Screen time was largely for leisure purposes and action games were most favoured. Smartphones were the most used device, mainly used in a solitary context in the bedroom. Non-screen-based sedentary behaviour was consistently low. Interviews suggested that during the pandemic, supporting factors for physical activity are: self-determination, enjoyment, parental support, and physical education; meanwhile, factors influencing screen time are: educational demands, device and internet availability, screen time opportunities, parental control, social facilitators, phone notifications, and emotional state.

Conclusions
Most participants were not able to stay active during the pandemic. Using digital platforms may be beneficial to shift some screen-based sedentary behaviour to ‘screen-based’ or ‘screen-prompted’ physical activity.
“A Vast Bed of Combustible Fuel”
Authors: Shutzer Matthew , Kodiveri Arpitha 
Published: March 2023

AbstractDoes climate change pose a crisis for the concept of nation-state sovereignty? This article explores how contemporary debates about climate and sovereignty are connected to deeper histories of empire and capitalism in the global South. Arguing against recent critical appraisals of sovereignty that emphasize the elision of nature from formal political and legal theory, the article reconstructs a genealogy of sovereign power in the major fossil fuel-producing territories of India spanning the nineteenth century to the present day. It brings to light three historical articulations of sovereignty that undergird contemporary modes of extractive dispossession enforced by the Indian state: the discovery of fossil fuels as subjects of sovereign power during an early colonial project to build prison complexes in Indian coal mines; the juridical remaking of “land” under Benthamite-inspired laws of “real property;” and the politicization of fossil fuels as an underground commons belonging to the abstract entity of the postcolonial nation.
Postoperative Spinal Cerebrospinal Fluid-Venous Fistulas Associated With Dural Tears in Patients With Intracranial Hypotension or Superficial Siderosis—A Digital Subtraction Myelography Study
Authors: Schievink Wouter I. , Maya Marcel M. , Chu Ray M. , Perry Tiffany G. , Moser Franklin G. , Taché Rachelle B. , Wadhwa Vikram S. , Prasad Ravi S. 
Published: March 2023

BACKGROUND:
Postoperative spinal cerebrospinal fluid (CSF) leaks are common but rarely cause extensive CSF collections that require specialized imaging to detect the site of the dural breach.

OBJECTIVE:
To investigate the use of digital subtraction myelography (DSM) for patients with extensive extradural CSF collections after spine surgery.

METHODS:
A retrospective review was performed to identify a consecutive group of patients with extensive postoperative spinal CSF leaks who underwent DSM.

RESULTS:
Twenty-one patients (9 men and 12 women) were identified. The mean age was 46.7 years (range, 17-75 years). The mean duration of the postoperative CSF leak was 3.3 years (range, 3 months to 21 years). MRI showed superficial siderosis in 6 patients. DSM showed the exact location of the CSF leak in 19 (90%) of the 21 patients. These 19 patients all underwent surgery to repair the CSF leak, and the location of the CSF leak could be confirmed intraoperatively in all 19 patients. In 4 (19%) of the 21 patients, DSM also showed a CSF-venous fistula at the same location as the postoperative dural tear.

CONCLUSION:
In this study, DSM had a 90% detection rate of visualizing the exact site of the dural breach in patients with extensive postoperative spinal CSF leaks. The coexistence of a CSF-venous fistula in addition to the primary dural tear was present in about one-fifth of patients. The presence of a CSF-venous fistula should be considered if CSF leak symptoms persist in spite of successful repair of a durotomy.
New onset asthma during pregnancy: two case reports
Authors: Schriek Paula S. , Bendien Saar A. , Feitsma Hanneke A. , van Exsel Jeroen 
Published: March 2023

Introduction: Asthma is the most common chronic respiratory disease during pregnancy. However, reports of new onset asthma during pregnancy are lacking. We report two cases of new onset asthma during pregnancy following respiratory tract infection, subsequently one case with M. pneumoniae infection and the other case with a combined infection with respiratory syncytial virus and rhinovirus. Case presentation: Both patients presented with the clinical features of an acute asthma exacerbation during pregnancy without a medical history of asthma. During follow up the diagnosis of asthma was supported by spirometry showing significant reversibility and elevated fractional exhaled nitric oxide (FeNO). Patients were hospitalized and received supplemental oxygen, treatment for an acute asthma exacerbation with systemic corticosteroids, high dose inhalation therapy. These therapeutic interventions subsequently led to a good outcome for the mother and newborn in both cases. Conclusions: New onset asthma should be part of the differential diagnosis in pregnant patients with respiratory symptoms, particularly in case of mycoplasma infection. Diagnosing asthma during pregnancy can be challenging. In these circumstances, additional diagnostic tests (like inflammatory biomarkers FeNO and blood eosinophils) can be helpful to support the diagnosis.
Sexual dimorphism in relationships between of plasma uric acid and some psycho-neuro-endocrine parameters
Authors: Bombushkar Igor , Korda Mykhaylo , Żukow Xawery , Popovychi. Igor 
Published: March 2023

Background. Earlier we found that effects of plasma nitrogenous metabolites as urea, creatinine, and bilirubin on neuro-endocrine parameters, as well as anxiety, are significantly different in men and women of different ages. The purpose of this study is to analyze the relationships between the plasma uric acid level and some psycho-neuro-endocrine parameters in the same cohort. Materials and Methods. The object of observation were almost healthy volunteers: 31 males (24÷69 y) and 30 females, from among them 18 postmenopausal (48÷76 y) and 12 of reproductive age (30÷45 y). In basal conditions we determined plasma levels of uric acid and adaptation hormones, estimated the severity of the trait and reactive anxiety, recorded the ongoing HRV and EEG. After 4 or 7 days, repeated testing was performed. Results. By uric acid regression models with stepwise exclusion, it was found that in men plasma uric acid downregulates the PSD of β-rhythm in P4 and δ-rhythm in others 4 loci, but upregulates the Asymmetry of δ-rhythm, variability of α-rhythm, PSD of θ-rhythm in P3 and O1 loci, Entropy of EEG in T4 as well as Testosterone plasma level. The measure of determination is 54,5%. In postmenopausal women, uricemia downregulates the Amplitude of β-rhythm and its PSD in 8 loci as well as sympathetic tone, but upregulates the PSD of HF and VLF bands HRV, Testosterone plasma level, PSD of θ-rhythm in F3 and O2 loci as well as the Laterality of δ-rhythm. The degree of determination of neuro-endocrine parameters is 94,4%. In women of reproductive age uricemia upregulates the Asymmetry and Amplitude of β-rhythm and its PSD in 6 loci, the Amplitude and Laterality of θ-rhythm and its PSD in F8 locus, as well as the PSD of α-rhythm in F8 locus. The degree of positive determination of EEGs parameters is 95,5%. Conclusion. Plasma uric acid has a modulating effect on neuro-endocrine parameters, but this effect is significantly different in men and women of different ages, which is due, apparently, to the influence of sex hormones on the expression of adenosine receptors in neurons.
Diagnosing acute bone and joint infection in children
Authors: Theologis Tim , Brady Mariea A. , Hartshorn Stuart , Faust Saul N. , Offiah Amaka C. 
Published: March 2023

Acute bone and joint infections in children are serious, and misdiagnosis can threaten limb and life. Most young children who present acutely with pain, limping, and/or loss of function have transient synovitis, which will resolve spontaneously within a few days. A minority will have a bone or joint infection. Clinicians are faced with a diagnostic challenge: children with transient synovitis can safely be sent home, but children with bone and joint infection require urgent treatment to avoid complications. Clinicians often respond to this challenge by using a series of rudimentary decision support tools, based on clinical, haematological, and biochemical parameters, to differentiate childhood osteoarticular infection from other diagnoses. However, these tools were developed without methodological expertise in diagnostic accuracy and do not consider the importance of imaging (ultrasound scan and MRI). There is wide variation in clinical practice with regard to the indications, choice, sequence, and timing of imaging. This variation is most likely due to the lack of evidence concerning the role of imaging in acute bone and joint infection in children. We describe the first steps of a large UK multicentre study, funded by the National Institute for Health Research, which seeks to integrate definitively the role of imaging into a decision support tool, developed with the assistance of individuals with expertise in the development of clinical prediction tools.Cite this article: Bone Joint J 2023;105-B(3):227–229.
Inverse design of a Si-based high-performance vertical-emitting meta-grating coupler on a 220 nm silicon-on-insulator platform
Authors: Yoon Jinhyeong , Kim Jae-Yong , Kim Junhyeong , Yoon Hyeonho , Neşeli Berkay , Park Hyo-Hoon , Kurt Hamza 
Published: March 2023

Efficient extraction of light from a high refractive index silicon waveguide out of a chip is difficult to achieve. An inverse design approach was employed using the particle swarm optimization method to attain a vertical emitting meta-grating coupler with high coupling efficiency in a 220-nm-thick silicon-on-insulator platform. By carefully selecting the figure of merit and appropriately defining parameter space, unique L-shape and U-shape grating elements that boosted the out-of-plane radiation of light were obtained. In addition, a 65.7% (−1.82  dB) outcoupling efficiency and a 60.2% (−2.2  dB) fiber-to-chip vertical coupling efficiency with an 88 nm 3 dB bandwidth were demonstrated by numerical simulation. Considering fabrication constraints, the optimized complex meta-grating coupler was modified to correspond to two etching steps and was then fabricated with a complementary metal-oxide-semiconductor-compatible process. The modified meta-grating coupler exhibited a simulated coupling efficiency of 57.5% (−2.4  dB) with a 74 nm 3-dB bandwidth in the C-band and an experimentally measured coupling efficiency of 38% (−4.2  dB).
Influencing factors of depressive symptoms among undergraduates: A systematic review and meta-analysis
Authors: Yang Le , Yuan Jiarong , Sun Huan , Zhao Yidan , Yu Jiajie , Li Youping 
Published: March 2023

Objective
This systematic review aims to examine the influencing factors of undergraduates’ depressive symptoms by summarizing the categories and intensity of the factors, to lay a foundation for subsequent research.

Methods
Two authors independently searched in Medline (Ovid), Embase (Ovid), Scopu, PsycINFO, PsycARTICLES, the Chinese Scientific Journal Database (VIP Database), China National Knowledge database (CNKI), and the WanFang database for cohort studies related to the influencing factors affecting depressive symptoms among undergraduates published prior to September 12, 2022. Adjusted Newcastle-Ottawa scale (NOS) was used to assess the risk of bias. Meta-analyses of regression coefficient estimates were performed to calculate pooled estimates with R 4.0.3 software.

Results
A total of 73 cohort studies were included, involving 46362 participants from 11 countries. Factors affecting depressive symptoms were classified into relational, psychological, predictors of response to trauma, occupational, sociodemographic and lifestyle factors. In Meta-analysis, 4 of 7 influencing factors were revealed to be statistically significant: negative coping (B = 0.98, 95%CI: 0.22–1.74), rumination (B = 0.06, 95%CI: 0.01–0.11), stress (OR = 0.22, 95%CI: 0.16–0.28) and childhood abuse (B = 0.42, 95%CI:0.13–0.71). No significant association was found in positive coping, gender and ethnicity.

Limitations
The current studies have the problems of inconsistent use of scales and large heterogeneity of research design, making it difficult to summarize, which is expected to be further improved in future research.

Conclusion
This review evidences the importance of several influencing factors of depressive symptoms among undergraduates. We advocate for more high-quality studies with more coherent and appropriate study designs and outcome measurement approaches in this field.

Trial registration
Systematic review registration: PROSPERO registration CRD42021267841.