bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Severity Model for Pediatric Autosomal Dominant Polycystic Kidney Disease Using 3D Ultrasound Volumetry
Authors: Breysem Luc , De Keyzer Frederik , Schellekens Pieter , Dachy Angélique , De Rechter Stephanie , Janssens Peter , Vennekens Rudi , Bammens Bert , Irazabal Maria V. , Van Ongeval Chantal , Harris Peter C. , Mekahli Djalila ,   in collaboration with the CRISP Consortium
Published: February 2023

Background
Height-adjusted total kidney volume (htTKV) measured by imaging defined as Mayo Imaging Class (MIC) is a validated prognostic measure for autosomal dominant polycystic kidney disease (ADPKD) in adults to predict and stratify disease progression. However, no stratification tool is currently available in pediatric ADPKD. Because magnetic resonance imaging and computed tomography in children are difficult, we propose a novel 3D ultrasound-based pediatric Leuven Imaging Classification to complement the MIC.

Methods
A prospective study cohort of 74 patients with genotyped ADPKD (37 female) was followed longitudinally with ultrasound, including 3D ultrasound, and they underwent in total 247 3D ultrasound assessments, with patients' median age (interquartile range [IQR]) at diagnosis of 3 (IQR, 0–9) years and at first 3D ultrasound evaluation of 10 (IQR, 5–14) years. First, data matching was done to the published MIC classification, followed by subsequent optimization of parameters and model type.

Results
PKD1 was confirmed in 70 patients (95%), PKD2 in three (4%), and glucosidase IIα unit only once (1%). Over these 247 evaluations, the median height was 143 (IQR, 122–166) cm and total kidney volume was 236 (IQR, 144–344) ml, leading to an htTKV of 161 (IQR, 117–208) ml/m. Applying the adult Mayo classification in children younger than 15 years strongly underestimated ADPKD severity, even with correction for height. We therefore optimized the model with our pediatric data and eventually validated it with data of young patients from Mayo Clinic and the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease used to establish the MIC.

Conclusions
We proposed a five-level Leuven Imaging Classification ADPKD pediatric model as a novel classification tool on the basis of patients' age and 3D ultrasound-htTKV for reliable discrimination of childhood ADPKD severity.
Incidence of Statin-Associated Adverse Events in Kidney Transplant Recipients
Authors: Bae Sunjae , Ahn JiYoon B. , Joseph Corey , Whisler Ryan , Schnitzler Mark A. , Lentine Krista L. , Kadosh Bernard S. , Segev Dorry L. , McAdams-DeMarco Mara A. 
Published: February 2023

Background
Statins are the third most prescribed drug class in kidney transplant recipients as cardiovascular disease is the leading cause of death in this population. However, statins' safety profile remains unclear in kidney transplant recipients who are uniquely burdened by concomitant immunosuppression and comorbidities. We conducted a national study to characterize the association of statin use with adverse events in kidney transplant recipients.

Methods
We studied adult (18 years or older) single-organ kidney transplant recipients in 2006–2016 with Medicare as primary payer (n=57,699). We used prescription drug claims to capture statin use and International Classification of Diseases 9/10 diagnosis codes to capture statin-related adverse events (post-transplant diabetes mellitus, hemorrhagic stroke, cataract, liver injury, and rhabdomyolysis). We conducted multivariable Cox regression for each outcome with statin use as a time-varying exposure.

Results
Post-transplant diabetes mellitus was the most common outcome (5-year Kaplan–Meier incidence; 43% in statin users versus 35% in nonusers), followed by cataract (22% versus 12%), liver injury (2% versus 3%), hemorrhagic stroke (1.9% versus 1.4%), and rhabdomyolysis (1.5% versus 0.9%). In our multivariable analysis, statin use was associated with higher hazard of post-transplant diabetes mellitus (adjust hazard ratio [aHR], 1.12; 95% confidence interval [95% CI], 1.07 to 1.18), cataract (aHR, 1.22; 95% CI, 1.14 to 1.31), and rhabdomyolysis (aHR, 1.37; 95% CI, 1.10 to 1.71) but lower hazard of liver injury (aHR, 0.82; 95% CI, 0.71 to 0.95). Statin use was not associated with hemorrhagic stroke (aHR, 1.04; 95% CI, 0.86 to 1.26).

Conclusions
Statins seem to be generally well tolerated in kidney transplant recipients. However, statin use might be associated with slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
A Pharmacist-Led Practice to Improve Perioperative Glycemic Control in Elective Surgery
Authors: Morin Nathaniel P. 
Published: February 2023

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<p>The South Health Campus (SHC) is a tertiary care hospital located in Calgary, Alberta, Canada. It has ~275 inpatient beds and multiple outpatient clinics serving Calgary and Southern Alberta. SHC has team-based pharmacy services coverage, through which the same pharmacist team will cover an inpatient unit and that unit’s corresponding outpatient clinic. For example, the inpatient cardiology pharmacist team also works in the hospital’s outpatient cardiology clinic and the inpatient neurology pharmacist team also works in the neurology outpatient clinic.</p>
<p>Surgical pharmacist team members split their time between the inpatient surgical unit and the outpatient pre-admission clinic (PAC). In the PAC, people with planned surgery are seen by a team of internists, anesthesiologists, nurses, and pharmacists if they have complex medical conditions (e.g., coronary artery disease, inflammatory bowel disease on biologic drug therapy, active cancer, or an indication for anticoagulation therapy). This pre-surgery process is to ensure that patients are medically optimized before surgery and to provide recommendations for perioperative care to the surgeons.</p>
<p>In the PAC, patients with diabetes are given standardized recommendations based on internal guidelines for which oral antidiabetic medications they should take or hold on the morning of surgery and, if applicable, how to adjust their long-acting insulin the day of or night before surgery.</p>
E-LKPD Berbasis HOTS dengan Liveworksheet Materi Sistem Pernafasan Manusia
Authors: Komang Tri Yoga Pramana  , Ndara Tanggu Renda  , I Nyoman Laba Jayanta  
Published: February 2023

Kegiatan pembelajaran saat ini lebih menekankan penghafalan sehingga siswa cenderung takut dan bingung ketika diberikan pertanyakan berbasis masalah oleh guru. Selain itu penggunaan media yang sangat minim menyebabkan siswa kurang antusias mengikuti pembelajaran. Tujuan dari penelitian ini yaitu mengembangkan E-LKPD Berbasis HOTS dengan liveworksheets untuk siswa kelas V. Jenis penelitian adalah pengembangan model ADDIE. Subjek penelitian yaitu 2 ahli materi dan 2 ahli media pembelajaran. Subjek uji coba produk yaitu 2 guru dan 18 siswa. Metode pengumpulan data dengan non tes berupa kuesioner. Instrument yang digunakan yaitu rating scale. Teknik menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu penilaian yang dilakukan oleh ahli materi pembelajaran yaitu 4,8 (sangat valid). Hasil penilaian yang dilakukan oleh ahli media pembelajaran yaitu 4,7 (sangat valid). Hasil penilaian kepraktisan yang dilakukan oleh guru yaitu 97% (sangat baik) dan siswa yaitu 93% (sangat baik). Disimpulkan bahwa E-LKPD Berbasis HOTS Dengan Liveworksheet layak digunakan. Implikasi pnelitian E-LKPD dapat membantu siswa belajar IPA.
Gifted Students within the Greek Educational Context: Challenges and Perspectives in the Frame of Contemporary Inclusive European Education
Authors: Riga Asimina , Malafantis Konstantinos 
Published: February 2023

Practitioners and researchers in the field of gifted education recognize cognitive and psychosocial variables as determining influences in the successful development of talent. Gifted children seem to manifest both signs of intelligence and strong abilities especially in sectors related to their interests provided that they are identified in time and they are appropriately motivated. The aim of the article is not only to present contemporary inclusive methods or both gifted and talented children’s education in European countries but also to focus on how such students are educated when it comes to the Greek curricula. This review paper further pinpoints the certain conditions under which Greek educational settings of gifted and talented students can become both feasible and effective. Τherefore, it concludes that gifted pupils of all levels in Greece often attend school classes without their individual abilities having been previously recognized in depth, nor their intrinsic needs having been sufficiently met, either. Additionally, the current school system actually fails to take full advantage of gifted students’ potential, a fact that obviously disrupts their motivation and impedes their school performance.
Diversity of Ralstonia solanacearum in the Southeastern United States
Authors: Robertson A.E , Fortnum B.A. , Wood T.C. , Kluepfel D.A. 
Published: February 2023

Summary
Bacterial (Granville) wilt, caused by Ralstonia solanacearum is a major disease of tobacco in both North and South Carolina. In contrast, Granville wilt rarely occurs on tobacco in Georgia and Florida. This difference was documented over fifty years ago and, today, it is still not understood. Isolates of R. solanacearum from tobacco and tomato were collected from Florida, Georgia, North and South Carolina. All isolates were identified as race 1, biovar 1. The polymerase chain reaction (PCR)-based fingerprinting technique, rep-PCR, was used to generate genomic fingerprints that were used to assess the genetic diversity of the R. solanacearum isolates. Bands were scored as present or absent and converted to band-sharing distances. A similarity matrix was generated and used to produce neighbor-joining trees. A highly branched tree that is indicative of the heterogeneity of the isolates in each of the states was constructed. South Carolina isolates segregated from Georgia, North Carolina and Florida isolates. Additionally, South Carolina isolates clustered as a function of the host from which they were isolated. Two isolates from tobacco and two from tomato, from both Georgia and South Carolina, were evaluated for aggressiveness on the susceptible tobacco cultivar, K 326, under controlled environment conditions. Five aggressiveness groups were defined. The tobacco isolates caused the most severe wilt symptoms, however one tobacco isolate was only weakly virulent. Only two of the four tomato isolates were pathogenic on tobacco. There was no correlation between genotypic and aggressiveness groupings. [Beitr. Tabakforsch. Int. 19 (2001) 323-331]
Perbandingan Profil Eritrosit Kucing yang Diberi Pakan Komersial Kering dan Pakan Tradisional dengan Imbuhan Minyak Magot Black Soldier Fly
Authors: Irawati Silvia , Gunawan I Wayan Nico Fajar , Kendran Anak Agung Sagung 
Published: February 2023

Pemberian pakan komersial kering dan pakan tradisional dengan imbuhan minyak magot black soldier fly memungkinkan terjadinya perubahan fisiologis tubuh hewan. Tujuan penelitian ini untuk mengetahui profil eritrosit kucing. Penelitian ini menggunakan rancangan acak Kelompok (RAK) yang terdiri atas empat perlakuan dan setiap perlakuan terdiri dari enam ekor kucing, dengan total 24 sampel darah. Perlakuan pakan komersial kering sebagai kontrol (P0), perlakuan pakan komersial kering diimbuhi minyak magot black soldier fly (P1), perlakuan pakan tradisional (P2), dan perlakuan pakan tradisional dan imbuhan minyak magot black soldier fly (P3). Data hasil pemeriksaan dianalisis menggunakan uji sidik ragam (ANOVA), untuk melihat pengaruh antar perlakuan dilanjutkan dengan uji Duncan. Hasil penelitian ini menunjukkan bahwa pemberian perlakuan pakan komersial kering dan pakan tradisional diimbuhi minyak magot black soldier fly secara statistika tidak berbeda nyata terhadap total eritrosit, kadar hemoglobin, dan packed-cell volume.
Deteksi Titer Antibodi Newcastle Disease pada Broiler yang Divaksinasi di Pembibitan Umur Satu Hari
Authors: Arnaya Ketut Ari Andhita Badraresta , Suardana Ida Bagus Bagus Kade , Nindhia Tjokorda Sari 
Published: February 2023

Vaksinasi saat antibodi maternal masih tinggi menyebabkan reaksi netralisasi antibodi sehingga respon kekebalan yang dihasilkan tidak optimal. Pengukuran titer antibodi pascavaksinasi merupakan indikator dalam menilai keberhasilan vaksinasi dan dapat diuji dengan serologis Hemagglutination Inhibition. Penelitian ini bertujuan untuk mengetahui hingga umur berapa titer antibodi seropositif pada broiler yang divaksinasi di pembibitan umur satu hari. Data diperoleh dengan cara pengambilan sampel secara acak dari populasi broiler yang diambil sebanyak 4 kali pada hari ke-7, ke-14, ke-21 dan ke-28. Data yang diperoleh di analisis menggunakan metode Analysis of Variance, kemudian dilanjutkan dengan analisis regresi. Hasil penelitian menunjukkan bahwa broiler yang divaksinasi di pembibitan umur satu hari menghasilkan titer seropositif hingga umur 13 hari dengan titer 4,2 HI log 2 dan mulai mengalami penurunan di umur 14 hari yaitu 3,9 HI log 2. Kesimpulan dari penelitian ini yaitu broiler yang divaksinasi di pembibitan umur satu hari menghasilkan titer seropositif hingga umur 13 hari. Saran perlu dilakukan vaksinasi booster di umur 13 hari pada broiler yang divaksinasi di pembibitan umur satu hari.
Perbandingan Profil Leukosit pada Kucing yang Diberi Pakan Tradisional dan Commercial Food Dengan dan Tanpa Ditambahkan Minyak Maggot Black Soldier Fly
Authors: Caroline Grace , Gunawan I Wayan Nico Fajar , Dharmayudha Anak Agung Gde Oka 
Published: February 2023

Meningkatnya populasi kucing, menjadikan kebutuhan pakan kucing ikut meningkat. Budidaya maggot BSF sedang tren di Indonesia, adapun produk yang dihasilkan seperti minyak maggot BSF. Minyak maggot BSF dapat dijadikan suplemen tambahan karena kandungan protein yang tinggi. Beberapa penelitian menunjukan bahwa maggot Black Soldier Fly merupakan serangga yang tinggi protein yang dianggap mampu mencukupi kebutuhan protein di dalam tubuh. Penelitian ini bertujuan untuk membandingkan profil leukosit pada kucing yang diberi pakan tradisional dan kucing yang diberi pakan komersial dengan kedua pakan tersebut ditambahkan minyak maggot BSF, serta untuk mengetahui apakah minyak maggot BSF mempengaruhi leukosit pada kucing yang mengkonsumsinya. Penelitian menggunakan 24 sampel darah kucing berusia kurang lebih satu hingga tiga tahun. Selanjutnya dibagi menjadi empat kelompok perlakuan. Kelompok kontrol adalah kucing yang diberi pakan commercial food (P0), kelompok perlakuan yang pertama adalah kucing diberi pakan commercial food dengan tambahan minya maggot BSF (P1), kelompok perlakuan yang kedua adalah kucing yang diberi pakan tradisional berupa ikan tongkol rebus (P2), dan yang terakhir kelompok perlakuan ketiga adalah kucing yang diberi pakan tradisional dengan tambahan minyak maggot BSF (P3). Data hasil pemeriksaan dianalisis menggunakan uji sidik ragam (ANOVA), untuk melihat pengaruh antar perlakuan dilanjutkan dengan uji Duncan. Hasil penelitian ini menunjukkan bahwa pemberian perlakuan pakan komersial kering dan pakan tradisional diimbuhi minyak magot black soldier fly secara statistika ada perbedaan nyata terhadap nilai neutrofil, eosinofil, dan limfosit pada kelompok kucing (P0) dengan (P1) (P<0.05), namun tidak ada perbedaan yang nyata antara kelompok (P2) dengan (P3) (P>0.05).
Outcome measures in neurosurgery: Is a unified approach better? A literature review
Authors: Algburi Hagar A. , Ismail Mustafa , Mallah Saad I. , Alduraibi Linah S. , Albairmani Sama , Abdulameer Aanab O. , Alayyaf Abdulaziz Saad , Aljuboori Zaid , Andaluz Norberto , Hoz Samer S. 
Published: February 2023

Background:
Accurate assessment and evaluation of health interventions are crucial to evidence-based care. The use of outcome measures in neurosurgery grew with the introduction of the Glasgow Coma Scale. Since then, various outcome measures have appeared, some of which are disease-specific and others more generally. This article aims to address the most widely used outcome measures in three major neurosurgery subspecialties, “vascular, traumatic, and oncologic,” focusing on the potential, advantages, and drawbacks of a unified approach to these outcome measures.

Methods:
A literature review search was conducted by using PubMed MEDLINE and Google scholar Databases. Data for the three most common outcome measures, The Modified Rankin Scale (mRS), The Glasgow Outcome Scale (GOS), and The Karnofsky Performance Scale (KPS), were extracted and analyzed.

Results:
The original objective of establishing a standardized, common language for the accurate categorization, quantification, and evaluation of patients’ outcomes has been eroded. The KPS, in particular, may provide a common ground for initiating a unified approach to outcome measures. With clinical testing and modification, it may offer a simple, internationally standardized approach to outcome measures in neurosurgery and elsewhere. Based on our analysis, Karnofsky’s Performance Scale may provide a basis of reaching a unified global outcome measure.

Conclusion:
Outcome measures in neurosurgery, including mRS, GOS, and KPS, are widely utilized assessment tools for patients’ outcomes in various neurosurgical specialties. A unified global measure may offer solutions with ease of use and application; however, there are limitations.
PHASE DIAGRAM OF THE Na, K//CL, CO3, WO4 SYSTEM
Authors: Кочкаров Ж.А. , Байсангурова А.А. , Хасбулатова З.С. 
Published: February 2023

Дифференциальным термическим анализом изучена фазовая диаграмма четырехкомпонентной взаимной системы Na, K//Cl, CO3, WO4. Определены фазовые равновесные состояния и координаты четверных нонвариантных точек Показана возможность химического синтеза оксидных вольфрамовых бронз щелочных металлов.
The phase diagram of the four-component reciprocal system Na, K//Cl, CO3, WO4 was studied by differential thermal analysis. Phase equilibrium states and coordinates of quadruple invariant points are determined. Possibility of chemical synthesis of oxide tungsten bronzes of alkali metals is shown.
PROSPECTS FOR THE DEVELOPMENT OF RURAL TOURISM IN THE MOSCOW REGION
Authors: Воробьева Т.А. , Клишина А.А. 
Published: February 2023

В связи с социально-экономическими вызовами, которые возникли в результате пандемии, возросла потребность населения в качественном отдыхе на территории России. В стране при поддержке государства стал активно развиваться внутренний туризм. Одним из перспективных его видов является сельский туризм, имеющий большое социально-экономическое значение и необходимые предпосылки для развития. В статье рассматривается современное состояние сельского туризма на примере одного из перспективных районов Московской области – городского округа Коломна.
Due to the socio-economic challenges that have arisen as a result of the pandemic and the complication of the political situation, the population’s need for quality rest in Russia has increased. Domestic tourism has been actively developing in the country with the support of the state. One of its promising types is rural tourism. The article discusses the current state and further development of agricultural tourism on the example of one of the developing areas Moscow region – Kolomna city district.
STABLE OXYGEN ANALYSIS PRE-TREATMENT TECHNIQUE FOR OSTRACODS IN THE CASPIAN REGION
Authors: Бердникова А.А. , Джавадова А. 
Published: February 2023

В статье экспериментальным путем подобрана оптимальная методика пробоподготовки раковин остракод для измерения соотношения стабильных изотопов кислорода. Благодаря проведенной работе удалось установить, что легкого физического воздействия –механического удаления налипшего загрязняющего материала тонкой щеткой-кисточкой, намоченной в дистиллированной воде или этаноле, достаточно. В применении кипячения, ультразвуковой очистки, использовании деионизированной воды или перекиси водорода необходимость существует исключительно в случае крайне высокой степени загрязнения раковины. Работа по такой системе имеет значительные преимущества: во-первых, исключается потеря проб и повторное загрязнение на этапе предварительной обработки; во-вторых, снижается рабочая нагрузка и значительно упрощается подготовка проб.
The article shows the optimal technique for ostracod shells sample preparation to measure the stable oxygen ratio selected experimentally. Slight physical impact – mechanical removal of adhering polluting material with a thin brush soaked in distilled water or ethanol – is sufficient. Boiling, ultrasonic cleaning, the use of deionized water or hydrogen peroxide is only in case of high contamination of the ostracod shell. Such work system has significant advantages: firstly, sample loss and re-contamination at the pre-treatment stage are eliminated; secondly, the workload is reduced and sample preparation is greatly simplified.
CULTIVATION OF CLOVER PLANT IN GRASS-PODZOL SOILS
Authors: Гусейнова А.К. , Гумбатов Г.С. 
Published: February 2023

Клевер (Medicago) растение относится к группе многолетних бобовых растений. Это одно из самых распространенных многолетних бобовых растений в нашей стране. Клевер используют как траву, растительную белково-витаминную муку, сено, силос, кормовые брикеты, зеленую подкормку. Такое разнообразие использования обусловлено тем, что клевер богат растительными белками с высоким содержанием незаменимых аминокислот. Он также характеризуется высоким содержанием зольных элементов, особенно кальция и магния, микроэлементов и бета-каротина. По содержанию основных аминокислот и микроэлементов клевер превосходит зерно, кукурузу и овес. Среди микроэлементов клевер содержит медь, марганец, молибден, бор и кобальт – элементы, необходимые для нормального развития организма животных.
Clover (Medicago) plant belongs to the group of perennial legumes. It is one of the most common perennial legumes in our country. Clover is used as grass, vegetable protein-vitamin flour, hay, silage, fodder briquettes, and green top dressing. Such diversity of use is determined by the fact that clover is rich in plant proteins with a high content of essential amino acids. It is also characterized by a high content of ash elements, especially calcium and magnesium, microelements and beta-carotene. Clover is superior to grain, corn and oats in terms of the content of basic amino acids and trace elements. Among microelements, clover contains copper, manganese, molybdenum, boron and cobalt – elements necessary for the normal development of the animal organism [1].