bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stable three-dimensional (un)charged AdS gravastars in gravity’s rainbow
Authors: Barzegar H. , Bigdeli M. , Bordbar G. H. , Panah B. Eslam 
Published: February 2023

AbstractIn this work, we study the three-dimensional AdS gravitational vacuum stars (gravastars) in the context of gravity’s rainbow theory. Then we extend it by adding the Maxwell electromagnetic field. We compute the physical features of gravastars, such as proper length, energy, entropy, and junction conditions. Our results show that the physical parameters for charged and uncharged states depend significantly on rainbow functions. Besides from charged state, they also depend on the electric field. Finally, we explore the stability of thin shell of three-dimensional (un)charged AdS gravastars in gravity’s rainbow. We show that the structure of thin shell of these gravastars may be stable and is independent of the type of matter.
Confronting the vector leptoquark hypothesis with new low- and high-energy data
Authors: Aebischer Jason , Isidori Gino , Pesut Marko , Stefanek Ben A. , Wilsch Felix 
Published: February 2023

AbstractIn light of new data we present an updated phenomenological analysis of the simplified $$U_1$$

U
1

-leptoquark model addressing charged-current B-meson anomalies. The analysis shows a good compatibility of low-energy data (dominated by the lepton flavor universality ratios $$R_D$$

R
D

and $$R_{D^*}$$

R

D
∗

) with the high-energy constraints posed by $$pp\rightarrow \tau {\bar{\tau }}$$

p
p
→
τ

τ

¯

Drell-Yan data. We also show that present data are well compatible with a framework where the leptoquark couples with similar strength to both left- and right-handed third-generation fermions, a scenario that is well-motivated from a model building perspective. We find that the high-energy implications of this setup will be probed at the 95% confidence level in the high-luminosity phase of the LHC.
Origin and evolution of SARS-CoV-2
Authors: Pagani Isabel , Ghezzi Silvia , Alberti Simone , Poli Guido , Vicenzi Elisa 
Published: February 2023

AbstractSARS-CoV-2 is a novel coronavirus that emerged in China at the end of 2019 causing the severe disease known as coronavirus disease 2019 (COVID-19). SARS-CoV-2, as to the previously highly pathogenic human coronaviruses named SARS-CoV, the etiological agent of severe acute respiratory syndrome (SARS), has a zoonotic origin, although SARS-CoV-2 precise chain of animal-to-human transmission remains undefined. Unlike the 2002–2003 pandemic caused by SARS-CoV whose extinction from the human population was achieved in eight months, SARS-CoV-2 has been spreading globally in an immunologically naïve population in an unprecedented manner. The efficient infection and replication of SARS-CoV-2 has resulted in the emergence of viral variants that have become predominant posing concerns about their containment as they are more infectious with variable pathogenicity in respect to the original virus. Although vaccine availability is limiting severe disease and death caused by SARS-CoV-2 infection, its extinction is far to be close and predictable. In this regard, the emersion of the Omicron viral variant in November 2021 was characterized by humoral immune escape and it has reinforced the importance of the global monitoring of SARS-CoV-2 evolution. Given the importance of the SARS-CoV-2 zoonotic origin, it will also be crucial to monitor the animal-human interface to be better prepared to cope with future infections of pandemic potential.
Addressing challenges in marine conservation with fish otoliths and their death assemblages
Authors: Leonhard Isabella , Agiadi Konstantina 
Published: February 2023

Abstract
Otolith death assemblages provide a valuable source of biological and ecological information that can help address three main problems in marine conservation: (a) the lack of pre-industrial, pre-human-impact baselines for evaluating change; (b) the inefficiency of survey methods for recording small and cryptic fish species; and (c) the absence of long-term data on environmental change impacts on marine ecosystems and fishes. We review here the current knowledge on the formation and preservation of otoliths and their death assemblages, and the methods to obtain, date and analyse them in order to detect changes in the species traits and ecology, the fish population structure and the palaeoceanographic shifts that drove them.
From geodiversity assessment to geosite analysis – a GIS-aided workflow from the Bakony–Balaton UNESCO Global Geopark, Hungary
Authors: Pál Márton , Albert Gáspár 
Published: February 2023

Abstract
Geodiversity and geosite assessments precede geoheritage and geotourism utilization. The process first determines the geodiversity value of an area (based on geoscientific attributions) and then the geotourism potential of the available sites. As a result, significant geosites can be identified, which are the bases for protection and tourism. During geosite assessment, scientific and infrastructural aspects are essential because spectacular sites and landscapes carrying intrinsic or visible values generate interest among tourists and professionals. In this study, a quantitative workflow to determine the geodiversity index over an area, evaluate geosites and monitor significant ones is presented. The study area is the Bakony–Balaton UNESCO Global Geopark, where no quantitative assessment was conducted previously. A GIS-based geodiversity analysis identified the most diverse areas which gave the basis for the geosite assessment done in a ‘geodiverse’ subregion of the geopark. The most important nine of the 75 identified potential geosites were chosen to examine the spatial variance of the assessment. By continuous monitoring, we got an image of what the visitors liked or did not like there. In this way, we were able to monitor the various opinions of geotourists to present unique development strategies for each of them. A connection between the location of geosites and the spatial distribution of geodiversity values was also determined by analysing and visualizing the connection between geodiversity and geosite assessment results.
Spatial decision-making support for geoheritage conservation in the urban and indigenous environment of the Auckland Volcanic Field, New Zealand
Authors: Németh Boglárka , Németh Károly 
Published: February 2023

Abstract

It is imperative today to make geoheritage conservation an essential part of all environmental standards and operational procedures. This is because geoheritage conservation secures the preservation of
in situ
geoheritage elements especially in urban environments such as Auckland. Geoheritage in Auckland is strongly associated with both indigenous culture and textbook geology of monogenetic volcanism, and it can play an important role in hazard forecasting and risk mitigation. To date, there has been a lack of policy or any planning tools based explicitly on the current geopreservation inventory. Here, we present an approach to support policy making informed by a spatial multi-criteria analysis that has long been used in environmental decision-making, supported by multi-layer mapping. A systematic literature review was undertaken to define the most accepted assessment criteria used in geoheritage evaluation. We identified six criteria for the base spatial layers of our analysis, highlighting the most suitable areas for geoheritage conservation. For cultural conservation, we used available archaeological shape files, indigenous land ownership data and elevation data (the volcanic cones had multiple roles in the life of first settlers, the ancestors of the Māori). Geographic Information Systems (GIS) multi-objective land use planning is an effective procedure for achieving complex planning and preservation objectives. It allows for outcomes based on quality data and sound analysis while minimizing compromise and conflict between geoheritage, social and cultural values.
Effects of Dietary Pediococcus acidilactici and Isomaltooligosaccharide on Growth Performance, Immunity, and Antioxidant Defense in Juvenile Common Carp
Authors: Maniat Milad , Salati Amir Parviz , Zanguee Nasim , Mousavi Seyed Mohammad , Hoseinifar Seyed Hossein 
Published: February 2023

The aim of this study was to investigate the synbiotic effects of Pediococcus acidilactici (PA) and isomaltooligosaccharide (IMO) on the performance of juvenile common carp (Cyprinus carpio). A total of 360 fish (

17.22
±
0.19

g) were randomly divided into six groups with three replicates of 20 fish each. The trial continued for 8 weeks. The control group was fed only basal diet; PA was fed basal diet supplemented with 1 g/kg (1010 CFU/kg) PA, IMO5 (5 g/kg IMO), IMO10 (10 g/kg IMO), PA-IMO5 (1 g/kg PA and 5 g/kg IMO), and PA-IMO10 (1 g/kg PA and 10 g/kg IMO). The results indicated that the diet containing 1 g/kg PA and 5 g/kg IMO significantly increased the fish growth performance and decreased the feed conversion ratio (

p
<
0.05

). Overall, blood biochemical parameters, serum (lysozyme, complements C3 and C4) and mucosal (protein, total immunoglobulin, and lysozyme) immune responses, and antioxidant defense of fish also improved in the PA-IMO5 group (

p
<
0.05

). Therefore, a combination of 1 g/kg (1010 CFU/kg) PA and 5 g/kg IMO can be recommended as a beneficial synbiotic additive and immunostimulant in juvenile common carp.
Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy
Authors: Cole Alexander J. , Panesso-Gómez Santiago , Shah Jaynish S. , Ebai Tonge , Jiang Qi , Gumusoglu-Acar Ece , Bello Maya G. , Vlad Anda , Modugno Francesmary , Edwards Robert P. , Buckanovich Ronald J. 
Published: February 2023

Abstract

Purpose:
We recently reported that the transcription factor NFATC4, in response to chemotherapy, drives cellular quiescence to increase ovarian cancer chemoresistance. The goal of this work was to better understand the mechanisms of NFATC4-driven ovarian cancer chemoresistance.

Experimental Design:
We used RNA sequencing to identify NFATC4-mediated differential gene expression. CRISPR-Cas9 and FST (follistatin)-neutralizing antibodies were used to assess impact of loss of FST function on cell proliferation and chemoresistance. ELISA was used to quantify FST induction in patient samples and in vitro in response to chemotherapy.

Results:
We found that NFATC4 upregulates FST mRNA and protein expression predominantly in quiescent cells and FST is further upregulated following chemotherapy treatment. FST acts in at least a paracrine manner to induce a p-ATF2–dependent quiescent phenotype and chemoresistance in non-quiescent cells. Consistent with this, CRISPR knockout (KO) of FST in ovarian cancer cells or antibody-mediated neutralization of FST sensitizes ovarian cancer cells to chemotherapy treatment. Similarly, CRISPR KO of FST in tumors increased chemotherapy-mediated tumor eradication in an otherwise chemotherapy-resistant tumor model. Suggesting a role for FST in chemoresistance in patients, FST protein in the abdominal fluid of patients with ovarian cancer significantly increases within 24 hours of chemotherapy exposure. FST levels decline to baseline levels in patients no longer receiving chemotherapy with no evidence of disease. Furthermore, elevated FST expression in patient tumors is correlated with poor progression-free, post–progression-free, and overall survival.

Conclusions:
FST is a novel therapeutic target to improve ovarian cancer response to chemotherapy and potentially reduce recurrence rates.
Efficient Probabilistic Prediction and Uncertainty Quantification of Tropical Cyclone–Driven Storm Tides and Inundation
Authors: Pringle William J. , Burnett Zachary , Sargsyan Khachik , Moghimi Saeed , Myers Edward 
Published: February 2023

Abstract
This study proposes and assesses a methodology to obtain high-quality probabilistic predictions and uncertainty information of near-landfall tropical cyclone–driven (TC-driven) storm tide and inundation with limited time and resources. Forecasts of TC track, intensity, and size are perturbed according to quasi-random Korobov sequences of historical forecast errors with assumed Gaussian and uniform statistical distributions. These perturbations are run in an ensemble of hydrodynamic storm tide model simulations. The resulting set of maximum water surface elevations are dimensionality reduced using Karhunen–Loève expansions and then used as a training set to develop a polynomial chaos (PC) surrogate model from which global sensitivities and probabilistic predictions can be extracted. The maximum water surface elevation is extrapolated over dry points incorporating energy head loss with distance to properly train the surrogate for predicting inundation. We find that the surrogate constructed with third-order PCs using elastic net penalized regression with leave-one-out cross validation provides the most robust fit across training and test sets. Probabilistic predictions of maximum water surface elevation and inundation area by the surrogate model at 48-h lead time for three past U.S. landfalling hurricanes (Irma in 2017, Florence in 2018, and Laura in 2020) are found to be reliable when compared to best track hindcast simulation results, even when trained with as few as 19 samples. The maximum water surface elevation is most sensitive to perpendicular track-offset errors for all three storms. Laura is also highly sensitive to storm size and has the least reliable prediction.

Significance Statement
The purpose of this study is to develop and evaluate a methodology that can be used to provide high-quality probabilistic predictions of hurricane-induced storm tide and inundation with limited time and resources. This is important for emergency management purposes during or after the landfall of hurricanes. Our results show that sampling forecast errors using quasi-random sequences combined with machine learning techniques that fit polynomial functions to the data are well suited to this task. The polynomial functions also have the benefit of producing exact sensitivity indices of storm tide and inundation to the forecasted hurricane properties such as path, intensity, and size, which can be used for uncertainty estimation. The code implementing the presented methodology is publicly available on GitHub.
Observational Constraints on the Submesoscale Sea Surface Height Variance of Balanced Motion
Authors: de Marez Charly , Callies Jörn , Haines Bruce , Rodriguez-Chavez Daniela , Wang Jinbo 
Published: February 2023

Abstract
A combination of in situ and remotely sensed observations are used to constrain the imprint of submesoscale turbulence in the sea surface height (SSH) field. The distribution of SSH variance across frequencies and wavenumbers is estimated by comparing an empirical model spectrum to two sets of observations. First, submesoscale SSH variance is constrained using a pair of GPS buoys spaced at about 10 km. From these data, one can estimate frequency spectra not only of SSH variance but also of the variance in the SSH difference between the buoys. The ratio between these two spectral estimates is sensitive to how much SSH variance is present in the submesoscale range and thus constrains the spectral roll-off of SSH variance in wavenumber space. Second, a combination of moored current meters and nadir altimetry is used to obtain an independent constraint. This constraint is enabled by geostrophy and the nonseparability of the wavenumber–frequency spectrum of SSH variance revealed by the GPS data. The frequency spectra of kinetic energy and SSH variance follow different power laws, and the difference constrains the spectral content in wavenumber space, allowing for a constraint without the need to actually resolve the submesoscales in space. In all four locations studied, spanning the midlatitude and subtropical ocean, these constraints indicate that the wavenumber spectral roll-off of submesoscale SSH variance is between about k−4 and k−5, where k is the wavenumber. These estimates are consistent with previous observations, model results, and theoretical predictions. They provide for a strong prior for the interpretation of upcoming high-resolution satellite data.
Energy Conversion Rate from Subinertial Surface Tides to Internal Tides
Authors: Tanaka Yuki 
Published: February 2023

Abstract
Subinertial, topographically trapped diurnal internal tides are an important energy source for turbulent mixing in the subarctic oceans. However, their generation may not be estimated by the conventional barotropic-to-baroclinic conversion because their vertical structure is sometimes barotropic, unlike superinertial internal tides that are always baroclinic. Here, a new energy diagram is presented, in which the barotropic mode is decomposed into the surface and topographic modes, with the latter being classified as part of the internal modes together with the baroclinic mode. The energy equation for the newly defined topographic mode is then derived, providing an appropriate formulation of the energy conversion rate from the subinertial surface tides to the topographically trapped internal tides. A series of numerical experiments confirm that the formulation successfully predicts the energy conversion rate for various cases, with the relative contribution of the baroclinic and topographic modes varying significantly depending on the bottom topography and stratification. Furthermore, this surface-to-internal conversion is demonstrated to give a significantly larger estimate than the barotropic-to-baroclinic conversion for subinertial tides. Applying the formulation to the results of a realistic numerical simulation in the Kuril Straits, an area with the strongest mixing due to subinertial diurnal tides, shows that the surface mode is converted into the baroclinic and topographic modes with comparable magnitudes, responsible for most of the energy dissipation in this area. These results indicate the need to reestimate the global distribution of the generation rate of the subinertial internal tides using our new formulation and to clarify their dissipation mechanisms.

Significance Statement
Diurnal internal tides in mid- to high-latitude oceans are very different from semidiurnal internal tides, in that they are trapped by topographic features and characterized by uniform rotation throughout the water column rather than by vertical oscillations within the water column. Focusing on this character, we formulate for the first time the generation rate of diurnal internal tides trapped over variable bottom topography. A series of idealized numerical experiments and application to the Kuril Straits show the validity and usefulness of this formulation, which provides a significantly larger generation estimate than previous studies. The results of this study are important for accurate global mapping of turbulent mixing induced by the breaking of internal tides.
Incidental Findings Protocol Implementation at a Level-I Trauma Center: A Review of Patient Follow-Up
Authors: Martin Sarah , LoPolito Andrew , Whitney Larissa D. , Fenninger Ashley , Bonneville Kelly , Ward Ryan , Graeff Shelby , Saint Fort Launick , Brown Catherine T. , Miller Virginia , Perea Lindsey L. 
Published: February 2023

Objectives Pan scanning in trauma patients has become routine, resulting in increased identification of incidental findings (IF), findings unrelated to the reason for the scan. This has posed a conundrum of ensuring patients have appropriate follow-up for these findings. We sought to evaluate our compliance and follow-up for patients after implementation of an IF protocol at our level-I trauma center. Methods We performed a retrospective review from 9/2020 to 4/2021, to encompass before and after protocol implementation. Patients were separated into PRE and POST groups. Charts were reviewed evaluating several factors including three- and six-month follow-ups on IF. Data were analyzed comparing PRE and POST groups. Results A total of 1989 patients were identified, 31.22% (n = 621) with an IF. 612 patients were included in our study. Compared to PRE, POST showed a significant increase in PCP notification (35% vs 22%, P < .001) and patient notification (82% vs 65%, P < .001). As a result, patient follow-up regarding IF at six months was significantly higher in POST (44%) v. PRE (29%), ( P < .001). There was no difference in follow-up based on insurance carrier. There was no difference in patient age for PRE (63 y) and POST (66 y) overall, ( P = .089); nor in age of patients who followed up; 68.8 PRE vs 68.2 years POST ( P = .819). Conclusion Implementation of an IF protocol with patient and PCP notification was significantly improved in overall patient follow-up for category one and two IF. Utilizing the results of this study, the protocol will be further revised to improve patient follow-up.
Exercise referral scheme participant characteristics, referral mode and completion status
Authors: Portman Robert M , Levy Andrew R , Allen Sarah F , Fairclough Stuart J 
Published: February 2023

Objective: There is recent evidence that exercise referral schemes (ERSs) are beginning to permit self-referral access. Notwithstanding this, to date it is unknown whether key referral characteristics, such as age, gender and socioeconomic status are associated with a greater likelihood of self-referring to an ERS, and whether self-referral participants are more or less likely to complete schemes, than traditional healthcare referrals. Design/Setting: This study presents an evaluation and cross-sectional exploration of key participant referral characteristics of those ( n = 647) who signed up to ‘Active West Lancs’; a 12-week ERS in the northwest of England. Methods: Chi-square analysis, tests of difference and binary logistic regression were conducted to explore associations between key referral characteristics and (1) the likelihood of accessing Active West Lancs via a self- or healthcare-referral and (2) the likelihood of completion. Results: About 56% of participants accessed the scheme via self-referral. These participants were more likely to be women, to report a musculoskeletal primary health condition, to access a specific site and to do so during spring. The scheme had an overall completion rate of 42.2%. Participants who were older, resided in less socioeconomically deprived neighbourhoods, and accessed a specific site were more likely to complete. Self-referral participants were not more or less likely to complete than those who enrolled via healthcare-referral. Conclusion: These data do not directly identify a clear benefit or detriment to Active West Lancs’ incorporation of self-referral participants. Notwithstanding this, enabling self-referral ERS access may widen scheme participation opportunities among those reluctant to seek referral from a healthcare provider and reduce the administrative burden for healthcare providers themselves.