bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrodeposited Cobalt–Copper mixed oxides for supercapacitor electrodes and investigation of the Co/Cu ratio on the electrochemical performance
Authors: Noormohammadi E. , Sanjabi S. , Soavi F. , Poli F. 
Published: February 2023

AbstractIn this study, different Cobalt–Copper mixed oxides compositions for supercapacitor electrodes have been prepared, by means of electrodeposition and thermal annealing. The chemical–physical and electrochemical characterization of electrodes, as well as the effect of different Co/Cu in the ratios on the crystal lattice, electrode morphologies, and electrochemical performance of the electrodes, were investigated using X-ray diffraction (XRD), scanning electron microscopic (SEM) and cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and galvanostatic charge/discharge (GCD) tests. The results indicated that the electrode prepared from 0.06 M CoSO4·7H2O + 0.04 M CuSO4·5H2O solution (CC4) had a better electrochemical performance. The initial capacity of the CC4 electrode was 28.3 mAh/g at a scan rate of 5 mV/s with a coulombic efficiency of 94%. CC4 electrode featured capacity retention of 79.2% at a constant current density of 1 A/g after 5000 cycles.
Automating surveillance for healthcare-associated infections: Rationale and current realities (Part I/III)
Authors: Shenoy Erica S. , Branch-Elliman Westyn 
Published: February 2023

Abstract
Infection surveillance is one of the cornerstones of infection prevention and control. Measurement of process metrics and clinical outcomes, such as detection of healthcare-associated infections (HAIs), can be used to support continuous quality improvement. HAI metrics are reported as part of the CMS Hospital-Acquired Conditions Program, and they influence facility reputation and financial outcomes.
Construction and applications of proximal maps for typical cocycles
Authors: PARK KIHO 
Published: February 2023

AbstractFor typical cocycles over subshifts of finite type, we show that for any given orbit segment, we can construct a periodic orbit such that it shadows the given orbit segment and that the product of the cocycle along its orbit is a proximal linear map. Using this result, we show that suitable assumptions on the periodic orbits have consequences over the entire subshift.
Now You See Me, Now You Don't: Anticipatory Coalitional Strategies in European Representative Democracies
Authors: Lindahl Jonas 
Published: February 2023

AbstractThis article approaches the puzzle of how parties can strategically anticipate coalition formation and make themselves more attractive coalition partners in their electoral strategies. It argues that parties can strategically adjust the salience of issues that are secondary to them in pursuit of increased ‘coalitionability’. It tests the argument through analysis of the salience of secondary policy dimensions of up to 232 European parties between 1970 and 2019, finding evidence that parties adjust the levels of salience of their secondary dimension in response to the probability of their being included in a coalition government and their distance from the coalition in which they are most likely to be included.
CLASSIC POLICY BENCHMARKS AND INEQUALITY
Authors: Bullard James 
Published: February 2023

AbstractThis note provides a nontechnical summary of a research paper (Bullard and DiCecio [2021, Classical policy benchmarks for economies with substantial inequality, Federal Reserve Bank of St. Louis, unpublished manuscript]) that I presented as the NIESR 2021 Dow Lecture on 9 February 2021. In the paper, we construct a simple benchmark macroeconomic model with substantial heterogeneity among households, enough to generate empirically plausible Gini coefficients for the distributions of consumption, income and financial wealth. The model includes aggregate shocks as well as both permanent and temporary idiosyncratic uncertainties. Four policymakers—implementing monetary, fiscal, labour market and education policies—act in concert to achieve a first-best allocation of resources. We argue that the roles of these policymaker types are ‘classic’ and match up well with observed policymaker roles in OECD countries. We regard this simple economy as a benchmark for the study of other aspects of the interaction between policy and inequality.
Cardiac manifestations of multisystem inflammatory syndrome of children after SARS-CoV-2 infection: a systematic review and meta-analysis
Authors: Carmona Carlos A. , Kuziez Mohamed , Freitas Caio F. , Cyrus John W. , Bain Jesse , Karam Oliver 
Published: February 2023

AbstractThis systematic review and meta-analysis were conducted to evaluate the prevalence of cardiac manifestations associated with multisystem inflammatory syndrome in children worldwide. We conducted electronic searches in Ovid MEDLINE, Ovid EMBASE, and the World Health Organization COVID-19 Literature Database from the inception of the SARS-CoV-2 pandemic to 1 January, 2022. Three authors independently screened the abstracts to determine eligibility, assessed methodology in the full texts, and extracted the data.We identified 2848 citations; 94 studies (14,932 patients) were included. The prevalence of vasopressors was 48.2% (95% CI 45.1%, 51.3%), left ventricular systolic dysfunction occurred in 37.2% (95% CI 34.1%, 40.3%), myocarditis in 34.1% (95% CI 30.5%, 37.8%), electrocardiographic dysrhythmias and abnormalities detected in 23.1% (95% CI 18.8%, 27.6%), coronary abnormalities identified in 18% (95% CI 16%, 20%), extracorporeal membrane oxygenation deployed in 2.2% (95% CI 1.7%, 2.8%), and mortality rate of 2.2% (95% CI 1.7%, 2.7%). A sensitivity analysis was performed after removing eleven studies with high bias, and the adjusted prevalence was not different than the original evaluation.In this meta-analysis of the largest cohort of multisystem inflammatory syndrome in children patients to date, we established the most accurate prevalence of the most common cardiac manifestations. Providers will subsequently have more precise data to anticipate patient outcomes and approach discussions concerning the frequency of monitoring outside the acute hospital period.
Immigration, skill acquisition, and fiscal redistribution in a search equilibrium model
Authors: Ikhenaode Bright Isaac 
Published: February 2023

AbstractAs recent immigration flows are reshaping the host countries workforce composition, this paper aims to assess whether age composition and skill adjustment dynamics play a relevant role in the welfare impact of immigration. To this end, we build and simulate a search and matching model that allows for endogenous natives’ skill acquisition and intergenerational transfers to analyze the welfare effects of immigration on a selected group of 19 OECD countries. The obtained results are then compared with those obtained under different assumptions on age composition and skill adjustment dynamics. Our comparative statics analysis shows that stronger job creation effects take place when natives adjust their skill in response to immigration. Moreover, taking into account age composition plays a key role in assessing the fiscal impact of immigration, which turns out to be positive when we include intergenerational transfers to retirees and immigration is high-skilled. Finally, we find that our model yields more optimistic welfare effects than standard search models that abstract from skill decision and intergenerational redistribution.
Predicting Covid-19 preventive behaviors based on constructs of health belief model
Authors: Heydari Azadeh , Isfahani Parvaneh , Bagheri Somayeh 
Published: February 2023

Abstract

Introduction and objective:
The prevalence of Covid-19 has become a clinical threat worldwide. However, knowledge about this new virus is limited. Therefore, this study was conducted to determine the preventive behaviors of Covid-19 based on the constructs of health belief model (HBM) in the clients of health centers in Zabol, Iran.

Methods:
This descriptive–analytical (cross-sectional) study was performed on 160 people referring to health centers in Zabol by the available method. A researcher-made questionnaire was used to collect data. Data were analyzed using SPSS20 software and appropriate statistical tests.

Results:
A positive and significant correlation was observed between preventive behaviors of Covid-19 and perceived benefit constructs (r = 0.29, P = 0.0001) and self-efficacy (r = 0.39, P = 0.0001). HBM constructs were able to predict about 36% of the variance of Covid-19 disease preventive behaviors, with self-efficacy (B = 0.134) being the strongest predictor.

Conclusion:
Since no specific and definitive treatment for Corona has been found yet, taking preventive measures can be the best way to prevent the spread of this disease in the community. Therefore, this can be achieved by raising awareness and preventive behaviors through health education.
Experimenting Musically with Democracy in Late Francoist and Post-Francoist Spain
Authors: ZUBILLAGA IGOR CONTRERAS 
Published: February 2023

AbstractThis article examines how musical practices in 1970s Spain formed ways of imagining democracy and how they participated in the wider social struggle to define freedom and equality for the final years of Franco's dictatorship and its immediate aftermath. I shall analyse two case studies: a large-scale experimental art festival held in the streets of Pamplona in 1972 and a grassroots musical collective created in 1973 on the initiative of the composer Llorenç Barber. Drawing on previous studies on the relationship between music and democracy, participatory art and the politics of spectatorship, and the insights of political science and philosophy into democracy, I offer a critical reassessment of the Pamplona festival and explore the relationship between grassroots collaboration and ideas of participatory democracy, and analyse the significance of this relationship in 1970s Spain.
Rethinking Post-Authoritarian Chile through Its Popular Music
Authors: PARTY DANIEL 
Published: February 2023

AbstractThis article is a study of Chilean popular music produced during the 1990s, the first decade following the end of the Pinochet dictatorship. The return of democracy and a period of strong economic growth contributed to a boom in the Chilean music industry. A wealth of music was recorded and the opportunities for listening to live music multiplied. The article's main objectives are to illuminate the ways in which Chilean popular music addressed democracy's inspiring promises and frustrating limits and to consider how Chileans used popular music to foster new post-authoritarian identities. First, it argues that music was used to reclaim national symbols that had been coopted by the dictatorship. Second, it considers the music of two generations of musicians who returned to the country after living in exile. Finally, it focuses on punk and hip-hop, the styles that produced the most significant examples of protest music in the post-authoritarian period.
Low-profile closely coupled dual-band MIMO antenna using double layer metasurface
Authors: Qiao Dayu , Han Liping , Liu Yufeng , Zhang Wenmei ,   Member, IEEE
Published: February 2023

AbstractA two-element low-profile closely coupled dual-band MIMO antenna is demonstrated for WiMAX applications. Based on the principle of metasurface (MTS) decoupling, a double-layer MTS consisting of pairs of elliptic patches with two different sizes is proposed. The MTS is loaded above a coupled dual-band MIMO antenna, and the mutual coupling in the lower and upper band is reduced by the larger and smaller elliptic patches, respectively. The edge-to-edge distance of antenna elements is only 0.01λ0 (λ0 is the free-space wavelength at 2.6 GHz). The measured results show that the working bandwidths of the MIMO antenna are 2.5–2.69 and 3.4–3.69 GHz. The −10 dB impedance bandwidths in two bands are 8.83% (2.49–2.72 GHz) and 8.50% (3.38–3.68 GHz), and the isolation between antenna elements is enhanced by 13.5 and 18.4 dB in two bands, respectively. Moreover, broadside radiation performances in two bands are obtained.
The Dynamics of Hidden Partisanship and Crossover Voting in Semi-Closed Primaries
Authors: Thornburg Matthew P. 
Published: February 2023

AbstractAmong US states with party registration, many allow the unaffiliated to choose either the Democratic or Republican primary. States with these semi-closed rules thus provide an option to voters with greater choice than registering with a single political party. Using the synthetic control method, I find that the introduction of semi-closed primaries is associated with growth in unaffiliated registration. However, the likelihood of unaffiliated registration is not even across the electorate in semi-closed states. I show that it is most common where a voter’s party is not competitive and the access unaffiliated registration provides to the strong party’s primary is valuable. Consistent with this instrumental motive, unaffiliated voters in semi-closed states use their freedom of choice to vote in the primary of the stronger party in the electorate. This leads to significant crossover voting among unaffiliated voters who do not identify with that party such as Democrats in red states or Republicans in blue states. These findings show the unintended consequences of electoral institutions and find primary crossover voting is more common under some circumstances than others.
Revolutionary Refugee Policy: Salvadorans and Statecraft in Sandinista Nicaragua (1979–1990)
Authors: De La Cruz Rachael 
Published: February 2023

AbstractDuring the 1980s, more than 20,000 Salvadorans fleeing the violence of the Salvadoran Civil War entered the neighboring country of Nicaragua. Their flight was part of a larger multidirectional migration out of El Salvador in which Salvadorans sought refuge across Central and North America. In response to this unprecedented influx of Salvadoran refugee men, women, and children, the Nicaraguan government—newly under the control of the revolutionary Sandinista National Liberation Front (FSLN)—declared that all refugees would be permitted “the opportunity to survive and produce.” This article argues that the timing of the refugees’ arrival proved mutually beneficial for both the Salvadorans and the FSLN by illustrating how Sandinista officials sought to further agrarian reform projects via refugee integration into agricultural cooperatives. As such, Nicaraguan refugee policy functioned as an integral part of Sandinista statecraft. Through an analysis of refugee-produced sources, government and UNHCR documents, and news reports, this article sheds new light on the entwined histories of Salvadoran refugees and the Sandinista state in the transnational context of the late Cold War period in Central America.
Adding pieces to the puzzle of differentiated-to-anaplastic thyroid cancer evolution: the oncogene E2F7
Authors: Gugnoni Mila , Lorenzini Eugenia , Faria do Valle Italo , Remondini Daniel , Castellani Gastone , Torricelli Federica , Sauta Elisabetta , Donati Benedetta , Ragazzi Moira , Ghini Francesco , Piana Simonetta , Ciarrocchi Alessia , Manzotti Gloria 
Published: February 2023

AbstractAnaplastic Thyroid Cancer (ATC) is the most aggressive and de-differentiated subtype of thyroid cancer. Many studies hypothesized that ATC derives from Differentiated Thyroid Carcinoma (DTC) through a de-differentiation process triggered by specific molecular events still largely unknown. E2F7 is an atypical member of the E2F family. Known as cell cycle inhibitor and keeper of genomic stability, in specific contexts its function is oncogenic, guiding cancer progression. We performed a meta-analysis on 279 gene expression profiles, from 8 Gene Expression Omnibus patient samples datasets, to explore the causal relationship between DTC and ATC. We defined 3 specific gene signatures describing the evolution from normal thyroid tissue to DTC and ATC and validated them in a cohort of human surgically resected ATCs collected in our Institution. We identified E2F7 as a key player in the DTC-ATC transition and showed in vitro that its down-regulation reduced ATC cells’ aggressiveness features. RNA-seq and ChIP-seq profiling allowed the identification of the E2F7 specific gene program, which is mainly related to cell cycle progression and DNA repair ability. Overall, this study identified a signature describing DTC de-differentiation toward ATC subtype and unveiled an E2F7-dependent transcriptional program supporting this process.
A vector-encoded bispecific killer engager to harness virus-activated NK cells as anti-tumor effectors
Authors: Floerchinger Alessia , Klein Jessica E. , Finkbeiner Maximiliane S. C. , Schäfer Theresa E. , Fuchs Gwendolin , Doerner Johannes , Zirngibl Hubert , Ackermann Maximilian , Kvasnicka Hans M. , Chester Kerry A. , Jäger Dirk , Ball Claudia R. , Ungerechts Guy , Engeland Christine E. 
Published: February 2023

AbstractTreatment with oncolytic measles vaccines (MV) elicits activation of immune cells, including natural killer (NK) cells. However, we found that MV-activated NK cells show only modest direct cytotoxic activity against tumor cells. To specifically direct NK cells towards tumor cells, we developed oncolytic measles vaccines encoding bispecific killer engagers (MV-BiKE) targeting CD16A on NK cells and carcinoembryonic antigen (CEA) as a model tumor antigen. MV-BiKE are only slightly attenuated compared to parental MV and mediate secretion of functional BiKE from infected tumor cells. We tested MV-BiKE activity in cocultures of colorectal or pancreatic cancer cells with primary human NK cells. MV-BiKE mediate expression of effector cytokines, degranulation and specific anti-tumor cytotoxicity by NK cells. Experiments with patient-derived pancreatic cancer cultures indicate that efficacy of MV-BiKE may vary between individual tumors with differential virus permissiveness. Remarkably, we confirmed MV-BiKE activity in primaryhuman colorectal carcinoma specimens with autochthonous tumor and NK cells.This study provides proof-of-concept for MV-BiKE as a novel immunovirotherapy to harness virus-activated NK cells as anti-tumor effectors.
Colorectal cancer patient-derived organoids and cell lines harboring ATRX and/or DAXX mutations lack Alternative Lengthening of Telomeres (ALT)
Authors: Falcinelli Marta , Dell’Omo Giulia , Grassi Elena , Mariella Elisa , Leto Simonetta Maria , Scardellato Sharon , Lorenzato Annalisa , Arena Sabrina , Bertotti Andrea , Trusolino Livio , Bardelli Alberto , d’Adda di Fagagna Fabrizio 
Published: February 2023

AbstractTelomere maintenance is necessary to maintain cancer cell unlimited viability. However, the mechanisms maintaining telomere length in colorectal cancer (CRC) have not been extensively investigated. Telomere maintenance mechanisms (TMM) include the re-expression of telomerase or alternative lengthening of telomeres (ALT). ALT is genetically associated with somatic alterations in alpha-thalassemia/mental retardation X-linked (ATRX) and death domain-associated protein (DAXX) genes. Cells displaying ALT present distinctive features including C-circles made of telomeric DNA, long and heterogenous telomeric tracts, and telomeric DNA co-localized with promyelocytic leukemia (PML) bodies forming so-called ALT-associated PML bodies (APBs). Here, we identified mutations in ATRX and/or DAXX genes in an extensive collection of CRC samples including 119 patient-derived organoids (PDOs) and 232 established CRC cell lines. C-circles measured in CRC PDOs and cell lines showed low levels overall. We also observed that CRC PDOs and cell lines did not display a significant accumulation of APBs or long telomeres with no appreciable differences between wild-type and mutated ATRX/DAXX samples. Overall, our extensive analyses indicate that CRC is not prone to engage ALT, even when carrying genetic lesions in ATRX and/or DAXX, and support the notion that ATRX/DAXX genomic footprints are not reliable predictors of ALT.
Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway
Authors: Wei Jing , Huang Xinxin , Zhang Xing , Chen Guanghong , Zhang Cheng , Zhou Xinyang , Qi Jingjing , Zhang Yan , Li Xia 
Published: February 2023

AbstractFibroblast-like synoviocytes (FLS) maintain chronic inflammation leading to joint destruction in rheumatoid arthritis (RA). Fatty acid β-oxidation (FAO) regulates cell function. Here, we aimed to investigate the effect of FAO enhanced by leptin on the characteristics of RA-FLS and elucidate the potential metabolic mechanism. Key enzymes involved in lipid metabolism were detected with qPCR in HSF, MH7A cell line and isolated RA-FLS treated with RA or healthy control (HC) serum. In some experiments, FAO inhibitor, etomoxir (ETO) or anti-leptin antibody were added into serum-treated RA-FLS. In other experiments, RA-FLS were stimulated with leptin together with ETO or AMP-activated protein kinase (AMPK) inhibitor compound C (CC) or silencing liver kinase B1 (LKB1). Cell proliferation, proinflammatory factor production, pro-angiogenesis, chemoattractive potential, FAO-related key enzymes, AMPK and LKB1 in FLS were analyzed. FAO-related key enzymes were evaluated in serum-treated RA-FLS with or without anti-leptin antibody. Related functions of leptin-stimulated RA-FLS were examined in the presence or absence of ETO. AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1) in leptin-stimulated RA-FLS were tested with western blot. Activation of AMPK in leptin-stimulated RA-FLS was detected after silencing LKB1. We found that MH7A cell line and RA serum-treated FLS exhibited upregulated FAO, and ETO could inhibit the proinflammatory phenotypes of RA-FLS. The addition of anti-leptin antibody suppressed the elevation of FAO mediated by RA serum. More importantly, leptin promoted the proinflammatory characteristics of RA-FLS, which was reversed by ETO. Leptin activated AMPK by upregulating LKB1. CC impaired leptin-induced CPT-1A expression in RA-FLS. Our study uncovers that elevated FAO mediated by leptin drives abnormal function of RA-FLS and suggests leptin or FAO inhibition may serve as a promising therapeutic strategy for RA.
Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer
Authors: Sun Lulu , Zhang Yi , Cai Jie , Rimal Bipin , Rocha Edson R. , Coleman James P. , Zhang Chenran , Nichols Robert G. , Luo Yuhong , Kim Bora , Chen Yaozong , Krausz Kristopher W. , Harris Curtis C. , Patterson Andrew D. , Zhang Zhipeng , Takahashi Shogo , Gonzalez Frank J. 
Published: February 2023

AbstractBile salt hydrolase (BSH) in Bacteroides is considered a potential drug target for obesity-related metabolic diseases, but its involvement in colon tumorigenesis has not been explored. BSH-expressing Bacteroides is found at high abundance in the stools of colorectal cancer (CRC) patients with overweight and in the feces of a high-fat diet (HFD)-induced CRC mouse model. Colonization of B. fragilis 638R, a strain with low BSH activity, overexpressing a recombinant bsh gene from B. fragilis NCTC9343 strain, results in increased unconjugated bile acids in the colon and accelerated progression of CRC under HFD treatment. In the presence of high BSH activity, the resultant elevation of unconjugated deoxycholic acid and lithocholic acid activates the G-protein-coupled bile acid receptor, resulting in increased β-catenin-regulated chemokine (C-C motif) ligand 28 (CCL28) expression in colon tumors. Activation of the β-catenin/CCL28 axis leads to elevated intra-tumoral immunosuppressive CD25+FOXP3+ Treg cells. Blockade of the β-catenin/CCL28 axis releases the immunosuppression to enhance the intra-tumoral anti-tumor response, which decreases CRC progression under HFD treatment. Pharmacological inhibition of BSH reduces HFD-accelerated CRC progression, coincident with suppression of the β-catenin/CCL28 pathway. These findings provide insights into the pro-carcinogenetic role of Bacteroides in obesity-related CRC progression and characterize BSH as a potential target for CRC prevention and treatment.