bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Kebiasaan Menggunakan Las Listrik dengan Penurunan Ketajaman Penglihatan pada Pekerja Bengkel Las di Toraja Utara Tahun 2021
Authors: Maria Sappa Atriani , Sihotang Hotmaulina 
Published: May 2023

Penurunan ketajaman penglihatan adalah ketidakmampuan mata dalam melihat objek secara jelas dan sangat bergantung pada kemampuan akomodasi mata. Tujuan penelitian ini adalah untuk mengetahui Hubungan Kebiasaan Menggunakan Las Listrik dengan Penurunan Ketajaman Penglihatan pada Pekerja Bengkel Las Di Kabupaten Toraja Utara Tahun 2021. Metode penelitian ini adalah deskriptif analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah pekerja bengkel las di Kabupaten Toraja Utara tahun 2021. Besarnya sampel 46 responden dengan menggunakan teknik total sampling. Pengumpulan data dilakukan dengan menggunakan lembaran kuesioner. Analisis data dilakukan dengan bantuan SPSS versi 23 menggunakan uji chi-Square dengan derajat kemaknaan p<0,05. Hasil penelitian, responden yang memiliki kebiasaan menggunakan las listrik yang baik sebanyak 16 responden (34,8%) dan responden dengan kebiasaan menggunakan las listrik yang buruk sebanyak 30 responden (65,2%) dan responden yang memiliki ketajaman penglihatan normal sebanyak 8 responden (17,4%) dan responden penurunan ketajaman penglihatan sebanyak 38 responden (82,6%). Berdasarkan hasil uji statistik SPSS didapat hasil p= 0,859 (?<0,05). Artinya tidak ada hubungan kebiasaan menggunakan las listrik dengan penurunan ketajaman penglihatan pada pekerja bengkel las di Kabupaten Toraja Utara Tahun 2021 atau Ha ditolak dan Ho diterima. Kesimpulan dari penelitian ini adalah tidak ada Hubungan Kebiasaan Menggunakan Las Listrik dengan Penurunan Ketajaman Penglihatan di Kabupaten Toraja Utara Tahun 2021. Di sarankan kepada pihak tenaga kesehatan Kabupaten Toraja Utara untuk memberikan pelayanan yang baik dan penyuluhan kepada pekerja Las dan masyarakat memeriksakan mata 6 bulan sekali.
Pengaruh Tingkat Pendidikan, Tingkat Kesehatan dan Pengangguran Terbuka Terhadap Tingkat Kemiskinan di Provinsi Bali
Authors: Made Ariasih Ni Luh , Yuliarmi Ni Nyoman 
Published: May 2023

Tingkat kemiskinan yang ada di Provinsi Bali terjadi dikarenakan adanya kesenjangan dan belum meratanya proses pembangunan ekonomi. Penelitian dilakukan untuk menganalisa secara simultan dan parsial tingkat pendidikan, tingkat kesehatan, serta tingkat pengangguran terbuka terhadap tingkat kemiskinan. Serta untuk menganalisa variabel bebas yang berpengaruh secara dominan terhadap tingkat kemiskinan. Riset ini diperoleh dari sumber sekunder dalam bentuk panel, yaitu data dalam kurun waktu 2010-2019 serta data individual pada Provinsi Bali di sembilan kabupaten/kota. Metode analisa mempergunakan regresi linear berganda, dengan random effect model. Hasil riset ini menyimpulkan bahwa secara simultan dan parsial tingkat pendidikan, serta pengangguran terbuka berpengaruh terhadap kemiskinan di Bali. Sementara itu, variabel tingkat kesehatan secara parsial berpengaruh negatif dan tidak signifikan terhadap kemiskinan di kabupaten/kota Provinsi Bali. Variabel yang berpengaruh secara dominan terhadap tingkat kemiskinan, yaitu tingkat pendidikan.
Efektivitas Ekstrak Daun Ruku-Ruku (Ocimum Tenuiflorum Linne) Dalam Menghambat Pertumbuhan Bakteri Salmonella Enterica Sevoar Typhi Dan Tinjauan Nya Menurut Pandangan Islam
Authors: Hanif Satria Irsyad , Keumala Dewi Intan , Djannatun Titiek , Arsyad Muhammad 
Published: May 2023

Bakteri Salmonella enterica sevoar typhi bersifat patogen bagi manusia. masuknya bakteri Salmonella enterica sevoar typhi ke dalam tubuh melalui makanan atau minuman yang terkontaminasi dapat mengakibatkan terjadinya demam tifoid, yaitu penyakit infeksi sistemik akut dengan gejala yang bervariasi dari ringan berupa demam, lemas serta batuk ringan hingga gejala berat seperti gangguan gastrointestinal. Penanganan penyakit infeksi saat ini masih menggunakan antibiotika, namun intensitas penggunaan antibiotik yang tinggi dapat menimbulkan resistensi. Ruku-ruku (Ocimum tenuiflorum L.) merupakan salah satu tanaman yang berkhasiat sebagai obat. untuk mengobati berbagai penyakit seperti demam, sariawan, panu, mual hingga muntah-muntah. Penelitian ini dilakukan untuk mengetahui efektivitas ekstrak daun ruku-ruku sebagai antibakteri dalam menghambat pertumbuhan bakteri Salmonella enterica sevoar typhi. Penelitian ini menggunakan desain penelitian eksperimental dengan metode disk diffusion. Populasi penelitian ini adalah bakteri Salmonella Enterica Sevoar typhi dan sampel penelitian ini adalah daun ruku-ruku (Ocimum tenuiflorum Linne). Penelitian ini menggunakan data kuantitatif primer. Teknik analisis data yang digunakan adalah program SPSS 25.0, uji statistik parametrik One-Way ANOVA dan Uji Post hoc Tukey. Hasil penelitian ini menunjukan bahwa DMSO 5% tidak memiliki aktivitas antibakteri terhadap Salmonella enterica sevoar typhi dengan tidak terbentuknya zona hambat pada kontrol negatif. Sehingga penelitian ini menyimpulkan bahwa efek antibakteri dari ekstrak daun Ruku-ruku masih belum bisa menggantikan antibiotik Ciprofloxacin yang memiliki diameter (mm) zona hambat yang cukup besar dengan rata-rata 41,47 mm. Artinya hasil penelitian ini belum dapat membuktikan bahwa ekstrak daun ruku-ruku memiliki daya hambat terhadap pertumbuhan bakteri spesifik Salmonella enterica sevoar typhi.
Analisis Desain Formulir Pengkajian Dokter IGD Di Rumah Sakit Islam Pondok Kopi
Authors: Ihza Ababil Alika 
Published: May 2023

Analisis desain formulir diperlukan agar pengguna bisa mempermudah membaca bentuk susunan item yang jelas dan informatif. karena formulir rekam medis sebagai media komunikasi maka dari itu formulir perlu di tata dan diisi sebaik mungkin agar menjadi suatu informasi yang berguna dan berkualitas karena data rekam medis akan dikumpulkan dan diproses melalui formulir.formulir mempunyai standar dalam pembuatan formulir yaitu terbagi dalam aspek anatomi, aspek fisik, aspek isi, Tujuan penelitian ini adalah mengidentifikasi desain formulir rekam medis formulir pengkajian dokter IGD di Rumah Sakit Islam Pondok Kopi Jakarta Timur metode penelitian dilakukan dengan cara observasi lapangan dengan menggunakan metode penelitian deskriptif dengan pendekatan kuantitatif.Dari hasil penelitian didapatkan bahwa aspek anatomi yang tidak sesuai dengan standar IFHIMA sebesar 75% yaitu terdapat pada bagian heading, instruction, close, aspek fisik yang sesuai sudah 100% yaitu warna, bahan, ukuran, aspek isi yang tidak sesuai sebesar 33,3% terdapat pada butir data yang tidak lengkap. formulir yang digunakan di Rumah Sakit Islam Pondok Kopi perlu dirancang kembali sesuai dengan pedoman IFHIMA dan SPO desain formulir di Rumah Sakit Islam Pondok Kopi belum tersedia, maka dari itu perlu di buat SPO agar tercapai nya standar mutu pelayanan informasi, menetapkan konsistensi pengumpulan data, dan mempercepat proses pelayanan
HALAL MEDIA AND ENTERTAINMENT IN CREATING JOB OPPORTUNITIES IN BRUNEI DARUSSALAM
Authors: Deuraseh Nurdeng , Bte Pg Mohd Anuar Siti Raudhatun Nabilah 
Published: May 2023

In Brunei, the Halal industry is not just focusing on food and beverages but also attempts to bring forward on other sectors including pharmaceutical, cosmetics, finances, tourism and media and entertainment. The establishment of Halalan Thayyiban Research Centre is an initiative disseminating and developing halal awareness in the society. One of the objectives of this research centre is to offer academic programmes in the field of Halalan Thayyiban. As this programme is still new and Halal industry is still developing in Brunei, this raises concern among the Halal graduates as their career path is still unclear and in need of guidance. In addition, the rate of unemployment in this country especially among youths is quite high. Therefore, this study aims to achieve three main objectives. Firstly, to provide an overview of Halal Media and Entertainment in Brunei. Secondly, to identify the challenges and opportunities in developing Halal Media and Entertainment in Brunei. Thirdly, to explore the job opportunities and career path available for Halal Science graduates specifically in Halal Media and Entertainment industry. To achieve these objectives, a semi-structured interview is conducted to assess employer’s suggestions on potential careers available in this sector. The process of search and data collection was also done by analyzing all the resources and materials related to the topic such as reviewing research paper, book, journal and articles as secondary sources. The finding of this study indicates that Halal Science graduates have higher chances to secure their job and career in private sectors compared to the government sectors. Some of the positions they may apply such as script supervisor, producer, part of censorship board in MOHA, part of Media team in Pusat Dakwah Islamiyah, religious officer, certified Islamic preacher, lecturer and etc.
Keywords: Unemployment, Job opportunity, Halal industry, Challenge, Halal Media and Entertainment.
Elucidating the Barriers to Colorectal Cancer Screening in a Rural Population
Authors: Nesiama Esere , Prakash Sameer , Mansi Tarek , Merza Nooraldin , Trammell Deborah , Balducci Michelle , Obokhare Izi 
Published: May 2023

Background
The incidence of colorectal cancer (CRC) has increased steadily in the last decade in the United States and is one of the leading causes of death. However, screening rates for colorectal cancer continue to remain at an all-time low in the United States and worldwide. Cancer screening programs can effectively reduce the burden of cancer when designed properly to ensure compliance and efficacy. The principal challenges in optimizing the delivery of effective cancer screening services and reducing inappropriate testing are predicated on (1) recognizing the main barriers preventing the delivery of life-preserving cancer screening available to eligible and vulnerable populations; (2) changing the behaviors of health care providers to follow recommended cancer screening guidelines for all patient encounters; and (3) changing the behaviors of individuals to obtain recommended screening education, tests and pursue follow-up.
Methodology
Surveys were distributed at various cancer screening events. The questionnaire was one page long and focused on the question: "What barriers do you experience with cancer screening? Please mark all that apply:" The barriers to cancer screening listed on the questionnaire were: embarrassment, unpleasantness of test, transportation, cost/lack of insurance, fear of results, lack of symptoms, lack of physician recommendations, lack of awareness, language barriers, and other causes. The questionnaire also recorded patient demographics including age, gender, and race.
Results
A total of 194 patients responded to our survey. 122 (62.9%) females, 71 males (36.6 %) and one did not specify. Genders were generally equally represented among all races. The ages ranged from 13 to 86 years with a mean of 51.79 and a standard deviation of 13.5. The overwhelmingly main barrier for screening was lack of funding or insurance (66%).
Conclusion
Given low screening rates for CRC, collaborative efforts should be made to remind more patients and have close follow up with their primary care physicians. Multilevel interventions can help address these barriers in preventing this deadly disease.
Epithelial to mesenchymal transition in mammary gland tissue fibrosis and insights into drug therapeutics
Authors: Syed Mudasir Ahmad , Bhat Basharat , Wali Abiza , Saleem Afnan , Ahmad Dar Lateef , Gugjoo Mudasir Bashir , Bhat Shakil , Saleem Bhat Sahar 
Published: May 2023

Background
The epithelial-mesenchymal transition (EMT) is a multi-step morphogenetic process in which epithelial cells lose their epithelial properties and gain mesenchymal characteristics. The process of EMT has been shown to mediate mammary gland fibrosis. Understanding how mesenchymal cells emerge from an epithelial default state will aid in unravelling the mechanisms that control fibrosis and, ultimately, in identifying therapeutic targets to alleviate fibrosis.

Methods
The effects of EGF and high glucose (HG) on EMT in mammary epithelial cells, MCF10A and GMECs, as well as their pathogenic role, were studied. In-silico analysis was used to find interacting partners and protein-chemical/drug molecule interactions.

Results
On treatment with EGF and/or HG, qPCR analysis showed a significant increase in the gene expression of EMT markers and downstream signalling genes. The expression of these genes was reduced on treatment with EGF+HG combination in both cell lines. The protein expression of COL1A1 increased as compared to the control in cells treated with EGF or HG alone, but when the cells were treated with EGF and HG together, the protein expression of COL1A1 decreased. ROS levels and cell death increased in cells treated with EGF and HG alone, whereas cells treated with EGF and HG together showed a decrease in ROS production and apoptosis. In-silico analysis of protein-protein interactions suggest the possible role of MAPK1, actin alpha 2 (ACTA2), COL1A1, and NFκB1 in regulating TGFβ1, ubiquitin C (UBC), specificity protein 1 (SP1) and E1A binding protein P300 (EP300). Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment suggests advanced glycation end products-receptor for advanced glycation end products (AGE-RAGE) signalling pathway, relaxin signalling pathway and extra cellular matrix (ECM) receptor interactions underlying fibrosis mechanism.

Conclusion
This study demonstrates that EGF and HG induce EMT in mammary epithelial cells and may also have a role in fibrosis.
Prognostic significance of SH2D5 expression in lung adenocarcinoma and its relation to immune cell infiltration
Authors: Zhou Hao , Li Shengjun , Lin Yuansheng 
Published: May 2023

Objective
Through analyzing the SH2D5 expression profiles, clinical features, and immune infiltration in lung adenocarcinoma (LUAD), the study was intended to discuss the correlations of SH2D5 with prognosis and immune infiltration in LUAD.

Methods
We downloaded transcriptome and clinical data of LUAD patients from TCGA, GEO, and CCLE databases. Sangerbox, R language, GEPIA, UALCAN, and Kaplan-Meier Plotter were adopted to analyze the SH2D5 expression patterns, prognosis, and clinical features. Spearman correlation analysis was performed to determine the association between SH2D5 expression and immune cell infiltration and immune checkpoint genes. The miRNA-SH2D5 relations were predicted by miRDB and starbase. Lastly, quantitative PCR, IHC and Western blot were implemented for validation.

Results
A prominent up-regulation of SH2D5 was noted in the LUAD group relative to the normal group, which was validated by quantitative PCR, IHC and Western blot. SH2D5 expression was inversely related to overall survival (OS) of LUAD patients as well as B cell immune infiltration. Additionally, SH2D5 expression was negatively correlated with dendritic cells resting (p < 0.001), plasma cells (p < 0.001), mast cells resting (p = 0.031) and T cells CD4 memory resting (p = 0.036) in LUAD patients with abundant SH2D5 expression correlated with poor prognosis. Furthermore, enrichment analysis suggested that SH2D5 was associated with lung cancer and immunity. Lastly, we investigated the relationship between the expression of SH2D5 and the use of antitumor drugs.

Conclusion
High SH2D5 expression shares an association with unfavorable prognosis in LUAD, and SH2D5 may also provide new ideas for immunotherapy as a potential therapeutic target.
Oral Morphine versus Rectal Ketamine in Pain Management during Burn Wound Dressing: An Open Label Randomized Clinical Trial
Authors: Atai Alice Gertrude , Andrew Kwikiriza , Okobi Okelue Edwards , Ekpa Queen Lutina-Oloom , Ekrebe Oghenekevwe , Koroyin Mercy Oyeinbrakemi , Dick Anthony I. , Bolaji Kafayat Oluwatoyin , Adedoye Enoobong Aderonke , Abubakar Aisha M. T. , Okobi Emeka Kenneth , Evbayekha Endurance O. 
Published: May 2023

Background: Oral morphine has been widely used to manage children’s pain during burn wound dressing. Rectal ketamine may also be safely administered to children.
Objective: To evaluate and compare the efficacy of oral morphine vs. rectal racemic ketamine in management of pain during burn wound dressing in a pediatric population in a rural study population.
Methods: This was a randomized open-label clinical trial done in a rural hospital in Uganda. Study participants were randomly assigned to one of the treatment groups, either oral morphine or rectal ketamine, with a ratio of 1:1. Overall, we enrolled 44 participants, with 22 in each treatment arm.
Assessment of baseline vital signs, including pulse rate, blood pressure, respiratory rate, temperature, oxygen saturation (SPO2), pain assessment (using Face Legs Activity Cry Consolability [FLACC]), and sedation scores (using Richmond’s agitation and sedation scale [RASS]) among others was done. Study participants were followed up hourly for 8 hours for outcomes of interest: adequate pain management/adverse events.
Results: The mean age of the study participants was 2.56 (±1.59) years. The overall mean intra-procedural pain difference score for children who received oral morphine was 2.7 (SD±2.2) compared to 0 (SD±0) among those who received rectal ketamine, and the mean difference of 2.7 was statistically significant (p < 0.0001). Sialorrhea (hyper-salivation) was the only significant adverse event, with more occurrence in the rectal Ketamine treatment arm (n= 8, 36.3%) compared to 1 (5%) in the oral Morphine treatment arm, p = 0.009. There were no significant adverse effects noted in either treatment arm.
Conclusion: The study showed the non-inferiority of rectal ketamine over oral morphine and concluded that administration of rectal ketamine was better at pain management and safety compared to oral morphine. Rectal ketamine is associated with an increased incidence of sialorrhea compared to oral morphine.
Workplace Psychosocial Resources and Risk of Sleep Disturbances Among Employees
Authors: Xu Tianwei , Rugulies Reiner , Vahtera Jussi , Stenholm Sari , Pentti Jaana , Magnusson Hanson Linda L. , Kecklund Göran , Mathisen Jimmi , Nordentoft Mads , Kivimäki Mika , Rod Naja Hulvej 
Published: May 2023

ImportanceWorkplace psychosocial resources naturally tend to cluster in some work teams. To inform work-related sleep health promotion interventions, it is important to determine the associations between clustering of workplace resources and sleep disturbances when some resources are high while others are low and to mimic an actual intervention using observational data.ObjectiveTo examine whether clustering of and changes in workplace psychosocial resources are associated with sleep disturbances among workers.Design, Setting, and ParticipantsThis population-based cohort study used data from the Swedish Longitudinal Occupational Survey of Health (2012-2018), the Work Environment and Health in Denmark study (2012-2018), and the Finnish Public Sector Study (2008-2014), collected biennially. Statistical analysis was conducted from November 2020 to June 2022.ExposureQuestionnaires were distributed measuring leadership quality and procedural justice (ie, vertical resources) as well as collaboration culture and coworker support (ie, horizontal resources). Resources were divided into clusters of general low, intermediate vertical and low horizontal, low vertical and high horizontal, intermediate vertical and high horizontal, and general high.Main Outcomes and MeasuresOdds ratios (ORs) and 95% CIs were reported from logistic regression models for the associations between the clustering of resources and concurrent and long-term sleep disturbances. Sleep disturbances were measured by self-administered questionnaires.ResultsThe study identified 114 971 participants with 219 982 participant-observations (151 021 [69%] women; mean [SD] age, 48 [10] years). Compared with participants with general low resources, other groups showed a lower prevalence of sleep disturbances, with the lowest observed in the general high group concurrently (OR, 0.38; 95% CI, 0.37-0.40) and longitudinally after 6 years (OR, 0.52; 95% CI, 0.48-0.57). Approximately half of the participants (27 167 participants [53%]) experienced changes in resource clusters within 2 years. Improvements in vertical or horizontal dimensions were associated with reduced odds of persistent sleep disturbances, and the lowest odds of sleep disturbances was found in the group with improvements in both vertical and horizontal dimensions (OR, 0.53; 95% CI, 0.46-0.62). A corresponding dose-response association with sleep disturbances was observed for decline in resources (eg, decline in both dimensions: OR, 1.74; 95% CI, 1.54-1.97).Conclusions and RelevanceIn this cohort study of workplace psychosocial resources and sleep disturbances, clustering of favorable resources was associated with a lower risk of sleep disturbances.
Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity
Authors: Galuppo Brittany , Umano Giuseppina Rosaria , Li Zhongyao , Van Name Michelle , Samuels Stephanie L. , Kien C. Lawrence , Cline Gary W. , Wagner David A. , Barbieri Emiliano , Tricò Domenico , Santoro Nicola 
Published: May 2023

ImportancePediatric obesity is a growing health care burden. Understanding how the metabolic phenotype of youth with obesity may modify the effect of intestinal fermentation on human metabolism is key to designing early intervention.ObjectiveTo assess whether adiposity and insulin resistance in youth may be associated with colonic fermentation of dietary fibers and its production of acetate, gut-derived hormone secretion, and adipose tissue lipolysis.Design, Setting, and ParticipantsCross-sectional study of youths aged 15 to 22 years with body mass index in the 25th to 75th percentile or higher than the 85th percentile for age and sex throughout the New Haven County community in Connecticut. Recruitment, studies, and data collection occurred from June 2018 to September 2021. Youths were assigned to a lean, obese insulin sensitive (OIS), or obese insulin resistant (OIR) group. Data were analyzed from April 2022 to September 2022.ExposureParticipants consumed 20 g of lactulose during a continuous 10-hour sodium d3-acetate intravenous infusion to measure the rate of appearance of acetate in plasma.Main Outcomes and MeasuresPlasma was obtained hourly to measure acetate turnover, peptide tyrosine tyrosine (PYY), ghrelin, active glucagon-like peptide 1 (GLP-1), and free fatty acids (FFA).ResultsA total of 44 youths participated in the study (median [IQR] age, 17.5 [16.0-19.3] years; 25 [56.8%] were female; 23 [52.3%] were White). Consequent to lactulose ingestion, there was a reduction of plasma FFA, an improvement of adipose tissue insulin sensitivity index, an increase in colonic acetate synthesis, and an anorexigenic response characterized by an increased plasma concentration of PYY and active GLP-1 and a reduction of ghrelin in the subgroups. Compared with the lean and OIS groups, the OIR group showed a less marked median (IQR) rate of acetate appearance (OIR: 2.00 [−0.86 to 2.69] μmol × kg−1 × min−1; lean: 5.69 [3.04 to 9.77] μmol × kg−1 × min−1; lean vs OIR P = .004; OIS: 2.63 [1.22 to 4.52] μmol × kg−1 × min−1; OIS vs OIR P = .09), a blunted median (IQR) improvement of adipose insulin sensitivity index (OIR: 0.043 [ 0.006 to 0.155]; lean: 0.277 [0.220 to 0.446]; lean vs OIR P = .002; OIS: 0.340 [0.048 to 0.491]; OIS vs OIR P = .08), and a reduced median (IQR) PYY response (OIR: 25.4 [14.8 to 36.4] pg/mL; lean: 51.3 [31.6 to 83.3] pg/mL; lean vs OIR P = .002; OIS: 54.3 [39.3 to 77.2] pg/mL; OIS vs OIR P = .011).Conclusions and RelevanceIn this cross-sectional study, lean, OIS, and OIR youth demonstrated different associations between colonic fermentation of indigestible dietary carbohydrates and the metabolic response, with OIR youth showing minimal metabolic modifications as compared with the other 2 groups.Trial RegistrationClinicalTrials.gov Identifier: NCT03454828