bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplement intravenous iron therapy in cardiac surgery
Authors: Stepin A. V. 
Published: July 2023

Introduction. Preoperative anemia which is present in 25–40 % of cardiac surgery patients increases the risk of adverse postoperative outcomes leading to higher medical expenses. The tendency to restrict allogenic transfusion rate has led to the search for new pharmacological solutions to correct anemia in the perioperative period, nevertheless the usage of intravenous iron preparations in cardiac surgery is still not a generally accepted standard of treatment.Aim — review of the literature about the effects of perioperative intravenous iron therapy on the clinical outcomes in cardiac surgery.Main findings. The use of intravenous iron preparations during the perioperative period in cardiac surgery results in better hemoglobin dynamics, iron repletion and less demand for allogenic transfusions. Anemia correction and lower transfusion rate might improve surgery outcomes such as mortality, intensive care unit length of stay and hospital length of stay. Iron repletion, regardless of presence of anemia, might improve the results of 6-minute walk test and patients’ quality of life after surgery. The optimal time for intravenous iron therapy in cardiac surgery is 10–14 days before surgery or immediately after the intervention. Ferric carboxymaltose can be administered in a single injection/infusion shortly before or after surgery.
Acute lymphoblastic leukemias in twins
Authors: Valiev T. T. , Volkova A. S. , Osipova I. V. 
Published: July 2023

Introduction. Identical twins are a unique model that can be used to assess the concordance of various diseases, including acute leukemia. It should be noted that acute leukemia is characterized with high concordance in cases of monovular twins or placentas adhesion, which confirms the model of development of this disease in the prenatal period.Aim — to present a clinical case of successful diagnosis and treatment of acute lymphoblastic leukemia in identical twins.Main findings. Clinical cases demonstrate the development of common-variant of B-cell precursor acute lymphoblastic leukemia in identical twins with three months interval. The disease course of one of the brothers was characterized by relapses, but treatment with highly effective protocols usage achieved 15-year remission without allogeneic stem cell transplantation. In case of second twin, disease-free life expectancy is 22 years.
Generative Pre-Trained Transformers, Natural Language Processing and Artificial Intelligence and Machine Learning (AI/ML) in Software Vulnerability Management: automations in the Software Bill of Materials (SBOM) and the Vulnerability-Exploitability eXchange (VEX)
Authors: Radanliev Petar 
Published: July 2023

<p>One of the most burning topics in cybersecurity in 2023 will undoubtedly be the compliance with the <strong>Software Bill of Materials.</strong> Since the US president issued the Executive Order 14028 on Improving the Nation’s Cybersecurity, software developers have prepared and bills are transmitted to vendors, customers, and users, but they don’t know what to do with the reports they are getting. In addition, since software developers have identified the values of the <strong>Software Bill of Materials</strong>, they have been using the reports extensively. This article presents an estimate of 270 million requests per month, just from form one popular tool to one vulnerability index. This number is expected to double every year and a half. This simple estimate explains the urgency for automating the process. We propose solutions based on artificial intelligence and machine learning, and we base our tools on the existing FAIR principles (Findable, Accessible, Interoperable, and Reusable). This methodology is supported with a case study research and Grounded theory, for categorising data into axis, and for verifying the values of the tools with experts in the field. We showcase how to create, and share <strong>Vulnerability Exploitability eXchange</strong> data, and automate the <strong>Software Bill of Materials</strong> compliance process with AI models and a unified computational framework combining solutions for the following problems: (1) the data utilisation problem, (2) the automation and scaling problem, (3) the naming problem, (4) the alignment problem, (5) the pedigree, and provenance problem, and many other problems that are on the top of mind for many security engineers at present. The uptake of these findings will depend on collaborations with government and industry, and on the availability and the ease of use of automated tools. </p>
The Transcription Factor RXRα in CD11c+ APCs Regulates Intestinal Immune Homeostasis and Inflammation
Authors: Manoharan Indumathi , Shanmugam Arulkumaran , Ramalingam Malarvizhi , Patel Nikhil , Thangaraju Muthusamy , Ande Satyanarayana , Pacholczyk Rafal , Prasad Puttur D , Manicassamy Santhakumar 
Published: July 2023

Abstract
APCs such as dendritic cells and macrophages play a pivotal role in mediating immune tolerance and restoring intestinal immune homeostasis by limiting inflammatory responses against commensal bacteria. However, cell-intrinsic molecular regulators critical for programming intestinal APCs to a regulatory state rather than an inflammatory state are unknown. In this study, we report that the transcription factor retinoid X receptor α (RXRα) signaling in CD11c+ APCs is essential for suppressing intestinal inflammation by imparting an anti-inflammatory phenotype. Using a mouse model of ulcerative colitis, we demonstrated that targeted deletion of RXRα in CD11c+ APCs in mice resulted in the loss of T cell homeostasis with enhanced intestinal inflammation and increased histopathological severity of colonic tissue. This was due to the increased production of proinflammatory cytokines that drive Th1/Th17 responses and decreased expression of immune-regulatory factors that promote regulatory T cell differentiation in the colon. Consistent with these findings, pharmacological activation of the RXRα pathway alleviated colitis severity in mice by suppressing the expression of inflammatory cytokines and limiting Th1/Th17 cell differentiation. These findings identify an essential role for RXRα in APCs in regulating intestinal immune homeostasis and inflammation. Thus, manipulating the RXRα pathway could provide novel opportunities for enhancing regulatory responses and dampening colonic inflammation.
Characterisation of a self-sustained, water-based condensation particle counter for aircraft cruising pressure level operation
Authors: Weber Patrick , Bischof Oliver F. , Fischer Benedikt , Berg Marcel , Hering Susanne , Spielman Steven , Lewis Gregory , Petzold Andreas , Bundke Ulrich 
Published: July 2023

Abstract. Aerosol particle number concentration measurements are a
crucial part of aerosol research. Vertical profile measurements and
high-altitude/low-pressure performance of the respective instruments become
more important for remote sensing validation and a vital tool for the
observation of climate variables. This study tests the new, commercially
available water condensation particle counter (MAGIC 210-LP) for the
deployment at aircraft cruising pressure levels that the European research
infrastructure IAGOS (In-service Aircraft for a Global Observing System;
http://www.iagos.org, last access: 2 May 2023) is aiming for by operating measurement instrumentation onboard passenger aircraft. We conducted laboratory experiments for conditions
to simulate passenger aircraft flight altitude at operation pressure. We
demonstrate that this type of water condensation particle counter shows
excellent agreement with a butanol-based instrument used in parallel. A
Faraday cup aerosol electrometer serves as the reference instrument.
Experiments are performed with test aerosol ammonium sulfate and fresh
combustion soot at pressure levels ranging from 700 to 200 hPa. For soluble particles like ammonium sulfate, the 50 % detection efficiency cut-off diameter (D50) is around 5 nm and does not differ significantly for all
performed experiments. For non-soluble fresh soot particles, the D50
cut-off diameter of approximately 10 nm does not vary substantially as a
function of pressure, whereas the 90 % detection efficiency cut-off
diameter D90 increases from 19 nm at 700 hPa to 37 nm at 200 hPa. The overall counting efficiency for particles larger than 40 nm reaches 100 % for working pressures of 200 hPa and higher.
Analysis of Factors Affecting Employee Productivity (Study on the Employee of PT Arkan Teknik Medan)
Authors: Niken Wulandari  
Published: July 2023

The purpose of this study is to determine the effect of compensation on work productivity, to determine the effect of the work environment on work productivity and to determine the effect of compensation and work environment on work productivity at PT. Arkan Field Engineering. The sampling technique in this study used saturated sampling. namely the determination of a sample of 48 respondents who are employees of the production department at PT Arkan Teknik Medan. This research method was collected through questionnaires that were processed and analyzed using data analysis and Multiple Regression. Then conducting a data quality test used is a validity test using Corrected Item Total and a reability test using Cronbach Alpha to test the hypothesis in this study. Researchers use the t test, and the F test and conduct a determination test. The results of this study showed that there was a significant positive influence of compensation variables on work productivity variables indicated by counting (4,520) > ttabel (1.68) with a significance value of 0.000< 0.05, and there was a significant positive influence of work environment variables on work productivity variables shown by counting (3.713) > ttabel (1.68) with a significance value of 0.001< 0.05, and for compensation and a positive work environment and significant work productivity of employees at PT Arkan Teknik Medan with a calculated value (109,040) > Ftabel (3.19) with a signification rate of 0.000. Furthermore, the R Square value obtained was 0.829 indicating about 82.9% significant influence of compensation and working environment.
Comparing the efficiency of technology and innovation of the EU and selected countries: the effects of EU framework programs
Authors: MANAVGAT Gökçe , DEMİRCİ Ayhan 
Published: July 2023

Objective: This study has two purposes. The first is to determine the relatively impact of EU framework programs (Lisbon Strategy to Horizon 2020) on the level of technological efficiency by comparing them with EU members and non-EU members selected countries. This paper also to compare technology efficiency of the EU member countries separately and as a union. The second is purpose to evaluate technological efficiency scores and the economic growth rates of the EU and the selected countries.Originality/Relevance: The relative efficiency of the technology and innovation of the EU was compared with other selected countries for 2000, 2005, 2010, 2015 and 2018 and evaluated. In previous studies, we could not find a study evaluating the long-term impact of the European Union's framework programs and its efficiency of innovation.Methodology/approach: For measuring efficiency, DEA method was used with two inputs and four outputs which is represented the technology and innovations.Main results: The evidence shows that the efficiency of the technology and innovation of the EU was quite low in 2000, and it has reached an increasing trend over the years and reached the full efficient in 2015 and 2018. The analyses which were done separately for 26 EU countries, the efficiency scores are relatively low among EU countries. It reveals that the EU provides a strong platform for R&D collaborations for creative destruction.Social/management contributions: The EU should continue to design promoting cooperation networks, frameworks programs to support stable economic growth patterns and long-term technology-based growth targets, considering the distinctive features of its economic system.
Decolonizing Evaluation: Truth, Power, and the Global Evaluation Knowledge Base
Authors: Hassnain Hur 
Published: July 2023

Evaluations play a critical role in shaping the way international development interventions are designed and managed. This contributes to the fact that there are intrinsic power dynamics at play during the production of evaluation knowledge. In the wake of growing commitments to deal with the repercussions of a colonial past and a prolonged history of white supremacy, there has been growing recognition of the need to decolonize evaluation theory and practice to help foster equality and ensure that evaluation knowledge is generated, shared, and understood universally. Increased efforts are being made to understand the risks involved if evaluations fail to utilize decolonized evaluation methods and approaches. We are faced with questions such as: How can we decolonize evaluation and disrupt unequal power relations? How can the evaluation process itself be transformative and an opportunity for co-liberation? What practical tools and steps facilitate power sharing? How can evaluation be used to advance decolonization and social justice?
This paper describes the connection between truth and power and how that relates to the evaluation and decolonization debates. It provides potential starting points for decolonizing evaluation practice, including some examples where this has already been tested. To conclude it focuses on the universalisation of evaluation knowledge and the need to ensure that evaluation knowledge is translated and disseminated via inclusive forms of communication to ensure that learning can be better understood and hence translated into action orientated practice from grassroot to government level.
The aim of this paper is to advance the discussion on decolonizing evaluation practice and provide some potential ways forward in terms of transforming evaluation theory and practice.
Keywords
Decolonizing evaluation, development, results, learning, accountability
Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection
Authors: Chen Hong , Zhang Hui , Li Jiayi , Wei Xianmei , Yu Chenjie , Zhao Yuanjin , Duan Maoli , Qian Xiaoyun , Gao Xia 
Published: January 2025

AbstractCisplatin‐induced ototoxicity is attributed to the aberrant accumulation of reactive oxygen species (ROS) within the inner ear. Antioxidants represented by α‐lipoic acid (ALA) have been demonstrated to scavenge ROS in the cochlea, while effective delivery of these agents in vivo remains a major challenge. Here, a novel polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for controllable is presented ALA delivery and deafness prevention. As the composite microcarriers exhibit excellent bioadhesion and responsive hierarchical capabilities, this can result in a prolonged retention time in vivo and allow for precise ALA delivery under light stimulation, which significantly enhances the therapeutic efficacy of ALA. Based on these features, both in vitro and in vivo experiments are demonstrated that the composite microcarriers combined with near‐infrared light irradiation can effectively attenuate cisplatin‐induced ototoxicity. These findings suggest that composite microcarriers are a viable approach for both inner ear medication delivery and the prevention of deafness.
Nanosize Non‐Viral Gene Therapy Reverses Senescence Reprograming Driven by PBRM1 Deficiency to Suppress iCCA Progression
Authors: Wu Xiwen , Zhang Yi , Ding Yuan , Yang Jiali , Song Zimin , Lin Shuirong , Zhang Ruhe , Wu Jun , Shen Shunli 
Published: January 2025

AbstractPolybromo‐1 (PBRM1) serves as a crucial regulator of gene transcription in various tumors, including intrahepatic cholangiocarcinoma (iCCA). However, the exact role of PBRM1 in iCCA and the mechanism by which it regulates downstream target genes remain unclear. This research has revealed that PBRM1 is significantly downregulated in iCCA tissues, and this reduced expression is linked to aggressive clinicopathological features and a poor prognosis. Furthermore, it is demonstrated that PBRM1 can impede iCCA progression, and a gene therapy nanomedicine is developed to treat iCCA in vivo by modulating PBRM1 expression. The heightened expression of PBRM1 induces by the nanomedicine substantially inhibited tumor growth in iCCA. Conversely, the decrease in PBRM1 results in the abnormal activation of the ERK1/2 signaling pathway, a reduction in p16, p53/p21, and cellular senescence, thereby promoting iCCA advancement. Treatment with U0126, an ERK1/2 inhibitor, effectively halted iCCA progression by regulating the PBRM1‐ERK1/2‐cellular senescence pathway. These findings underscore the significant role of PBRM1 in controlling iCCA progression and predicting prognosis. Targeting the PBRM1‐ERK1/2‐cellular senescence pathway with U0126 shows promise for clinical applications in treating iCCA.
Morphological Evolution of Sn‐Metal‐Based Anodes for Lithium‐Ion Batteries Using Operando X‐Ray Imaging
Authors: Bouabadi Bouchra , Hilger André , Kamm Paul H. , Neu Tillmann R. , Kardjilov Nikolay , Sintschuk Michael , Markötter Henning , Schedel‐Niedrig Thomas , Abou‐Ras Daniel , García‐Moreno Francisco , Risse Sebastian 
Published: January 2025

AbstractSn‐based electrodes are promising candidates for next‐generation lithium‐ion batteries. However, it suffers from deleterious micro‐structural deformation as it undergoes drastic volume changes upon lithium insertion and extraction. Progress in designing these materials is limited to complex structures. There is a significant need to develop an alloy‐based anode that can be industrially manufactured and offers high reversible capacity. This necessitates a profound understanding of the interplay between structural changes and electrochemical performance. Here, operando X‐ray imaging is used to correlate the morphological evolution to electrochemical performance in foil and foam systems. The 3D Sn‐foam‐like structure electrode is fabricated in‐house as a practical approach to accommodate the volume expansion and alleviate the mechanical stress experienced upon alloying/dealloying. Results show that generating pores in Sn electrodes can help manage the volume expansion and mitigate the severe mechanical stress in thick electrodes during alloying/dealloying processes. The foam electrode demonstrates superior electrochemical performance compared to non‐porous Sn foil with an equivalent absolute capacity. This work advances the understanding of the real‐time morphological evolution of Sn bulky electrodes.
Inadvertent insertion of dialysis catheter into subclavian artery treated with a covered stent: A case report
Authors: Takenobu Yohei , Furuta Akihiro , Haga Sumire , Yukawa Hiroshi , Nomura Noriko , Toyama Mizuha , Okada Akihiro , Kawauchi Takeshi , Terada Yukinori , Inoue Manabu , Hashimoto Kenji 
Published: January 2025

AbstractBackgroundWhen inserting central venous catheters, inadvertent injury of major vessels is a rare yet critical complication. Direct surgery is sometimes overly invasive. This report describes a subclavian artery injury caused by inadvertent cannulation of a dialysis catheter, successfully treated with a covered stent.Case PresentationAn 82‐year‐old woman with acute renal failure due to sepsis required emergency dialysis. During the insertion of a 12‐Fr dialysis catheter into the right jugular vein, pulsatile reflux was noted. Computed tomography revealed catheter misplacement in the subclavian artery. Considering the patient's fragility, endovascular repair was performed. After embolization of side branches, a GORE VIABAHN stentgraft was delivered using a pull‐through technique and deployed to seal the injury site. The patient was discharged without neurological or vascular complications.ConclusionCovered stents offer an effective solution for major vessel injuries requiring immediate hemostasis, particularly when direct surgery is complicated by underlying medical or anatomical conditions.
‘They have somewhere to turn to’: Wellbeing support for newly arrived refugee and migrant adolescents in English secondary schools
Authors: Kelley Aimee , Verelst An , Derluyn Ilse 
Published: January 2025

AbstractChildren continue to comprise a significant portion of refugees and migrants worldwide and may be impacted by challenges or trauma prior to or during their journey, or after arrival in the host country. School serves as a constant place in the lives of many of these newly arrived children, and a potential setting for wellbeing support. However, there is a gap in understanding how young newcomers are supported at school and by whom; this is especially unclear in an education system like England's, which has a default policy of directly mainstreaming non‐English‐speaking students, which many young newcomers are. We interviewed 29 school staff members at eight secondary schools to gather their perspectives on who provides wellbeing support to young newcomers and the nature of such support. Using thematic analysis, we found that the majority of wellbeing support for young newcomers is performed by English as an additional language (EAL) staff and that the main form of support provided is through individualised relationship building, which in turn mutually fosters other types of support. Using Gholami's framework of moral care and caring pedagogy as central to teachers' praxis, we discuss how care is at the core of EAL staff actions in supporting newcomer wellbeing and how these staff members at times prioritise care over learning. Our findings have important implications for both school staff and newcomer students, for which we provide several recommendations.