bluuebunny/crossref_metadata_2025_split huggingface dataset:
RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults
Authors: Wen Patrick Y. , van den Bent Martin , Youssef Gilbert , Cloughesy Timothy F. , Ellingson Benjamin M. , Weller Michael , Galanis Evanthia , Barboriak Daniel P. , de Groot John , Gilbert Mark R. , Huang Raymond , Lassman Andrew B. , Mehta Minesh , Molinaro Annette M. , Preusser Matthias , Rahman Rifaquat , Shankar Lalitha K. , Stupp Roger , Villanueva-Meyer Javier E. , Wick Wolfgang , Macdonald David R. , Reardon David A. , Vogelbaum Michael A. , Chang Susan M. 
Published: September 2023

PURPOSE The Response Assessment in Neuro-Oncology (RANO) criteria for high-grade gliomas (RANO-HGG) and low-grade gliomas (RANO-LGG) were developed to improve reliability of response assessment in glioma trials. Over time, some limitations of these criteria were identified, and challenges emerged regarding integrating features of the modified RANO (mRANO) or the immunotherapy RANO (iRANO) criteria. METHODS Informed by data from studies evaluating the different criteria, updates to the RANO criteria are proposed (RANO 2.0). RESULTS We recommend a standard set of criteria for both high- and low-grade gliomas, to be used for all trials regardless of the treatment modalities being evaluated. In the newly diagnosed setting, the postradiotherapy magnetic resonance imaging (MRI), rather than the postsurgical MRI, will be used as the baseline for comparison with subsequent scans. Since the incidence of pseudoprogression is high in the 12 weeks after radiotherapy, continuation of treatment and confirmation of progression during this period with a repeat MRI, or histopathologic evidence of unequivocal recurrent tumor, are required to define tumor progression. However, confirmation scans are not mandatory after this period nor for the evaluation of treatment for recurrent tumors. For treatments with a high likelihood of pseudoprogression, mandatory confirmation of progression with a repeat MRI is highly recommended. The primary measurement remains the maximum cross-sectional area of tumor (two-dimensional) but volumetric measurements are an option. For IDH wild-type glioblastoma, the nonenhancing disease will no longer be evaluated except when assessing response to antiangiogenic agents. In IDH-mutated tumors with a significant nonenhancing component, clinical trials may require evaluating both the enhancing and nonenhancing tumor components for response assessment. CONCLUSION The revised RANO 2.0 criteria refine response assessment in gliomas.
Disentangling COVID-19, Economic Mobility, and Containment Policy Shocks
Authors: Camehl Annika , Rieth Malte 
Published: September 2023

We study the dynamic interaction between COVID-19, economic mobility, and containment policy. We use Bayesian panel structural vector autoregressions with daily data for 44 countries, identified through traditional and narrative sign restrictions. We find that incidence shocks and containment shocks have large and persistent effects on mobility, morbidity, and mortality that last for one to two months. These shocks are the main drivers of the pandemic, explaining between 20 and 60 percent of the average and historical variability in mobility, cases, and deaths worldwide. The policy trade-off associated to nonpharmaceutical interventions is 1 pp less economic mobility per day for 8 percent fewer deaths after 3 months. (JEL C43, H51, I12, I18, O15)
In vitro analysis of quercetin-like compounds from mistletoe Dendrophthoe pentandra (L.) Miq as a potential antiviral agent for Newcastle disease
Authors: Mochamad Lazuardi , Malarvili Selvaraja , Jasmine Khairat , Lim Vuanghao 
Published: September 2023

Background: Recent evidence suggests that some flavonoid compounds obtained from crude methanol extract of mistletoe leaves (Dendrophthoe pentandra L. Miq), also known as Benalu Duku (BD), have antimicrobial effects. Thus, the plant has the potential to eliminate viruses that may cause outbreaks in chicken farms. This study aimed to prove the in vitro ability of flavonoid compounds, namely quercetin-like compounds (QLCs), to eliminate field viruses, specifically the Newcastle disease virus (NDV). Methods: This research was performed in two stages. An in vitro test was used with a post-test of the control groups designed at a significance of 0.05. BD leaves (5 kg) were extracted using a maceration method with methanol and then separated into hexane, chloroform, ethyl acetate, and methanol fractions. The final extracted products were separated using semi-preparative high-performance liquid chromatography (HPLC) to obtain QLCs. The QLCs were identified and compared with quercetin using HPLC, proton and carbon nuclear magnetic resonance spectrometry, Fourier transform infrared spectrophotometry, and ultra-performance liquid chromatography–mass spectrometry. The activity of QLCs was tested in vitro against the NDV at a virulency titer of 10−5 Tissue Culture Infectious Dose 50% (TCID50) and in chicken kidney cell culture. Results: Solutions of 0.05% (w/v) QLCs were discovered to have antiviral activity against NDVs, with an average cytopathogenic effect antigenicity at a 10−5 dilution (p<0.05). Conclusions: QLCs from flavonoids from the leaves of BD have antiviral bioactivity against NDVs and may have the potential to be developed as medicinal compounds for the treatment of other human or animal viral infections.
Evidencias de validez de una escala para evaluar el ajuste a la vida universitaria
Authors: Mata Salas Adriana , Moreira-Mora Tania , Pizarro-Aguilar Laura 
Published: September 2023

El propósito de la investigación fue desarrollar una escala para medir el constructo de ajuste a la vida universitaria. El modelo teórico del constructo se basó en tres dimensiones: académica, social e institucional y con un diseño correlacional se utilizaron diversas técnicas para recolectar las evidencias de validez. La muestra principal estuvo conformada por 673 estudiantes: 42,1% mujeres, 57,7% hombres y 0,3% otro, con un promedio de 18,29 años. En el primer análisis se encontraron evidencias asociadas al contenido de las dimensiones de la escala denominada AjusteU. En el análisis de validez convergente se encontró una correlación de 0,582 a un nivel de significancia del 0.01 (bilateral) con el instrumento CAVU, otra medida que está teóricamente relacionada con el ajuste a la vida universitaria. En el tercer análisis se validó el planteamiento teórico con los datos empíricos mediante un modelo de ecuaciones estructurales. Finalmente, en el análisis predictivo se comprobó que la puntuación de la escala AjusteU se asoció significativamente con el rendimiento del primer periodo universitario. La principal conclusión es que estas evidencias de validez y confiabilidad permiten un uso adecuado de los resultados, especialmente, en la toma de decisiones oportunas para favorecer el proceso de transición de secundaria a la educación superior.
Digital workflows part 1: applications of digital technology in orthodontics
Authors: Keating Chris , Haworth Jennifer , Ireland Tony , Parvizi Farnaz 
Published: September 2023

This is the first article in a two-part series considering the relevance and clinical uses of digital technologies in relation to orthodontics. The aim is to take a closer look at a ‘point-of-care’ digital service and highlight the key areas in which digital workflows have been employed, along with areas of future development. The second article will document the application of digital workflows in joint orthodontic/orthognathic treatment and present two clinical cases which have undergone treatment by means of a digital workflow. CPD/Clinical relevance: Digital technologies can enhance orthodontic clinical care.
Systematic Literature Review of Therapeutic Use of Autonomous Sensory Meridian Response (ASMR) and Short-Term ASMR Auditory Training Trial
Authors: Cubelo Christine 
Published: September 2023

This thesis consists of 2-parts: a systematic review of current publications on therapeutic use of autonomous sensory meridian response (ASMR), and a within-subjects auditory training trial using ASMR videos. The main intent is to explore ASMR as potentially therapeutically beneficial for those with atypical sensory processing. Many hearing related disorders and mood or anxiety symptoms overlap with symptoms of sensory processing issues. For this reason, inclusion and exclusion criteria of the systematic review were generated in an effort to produce optimal search outcomes, and avoid overly confined criteria that would limit yielded results.
Criteria for inclusion in the review for Part 1 are: (1) adult participants diagnosed with hearing loss or atypical sensory processing, (2) inclusion of measures related to ASMR as a treatment method and (3) published between 2000 and 2022. A total of 1,088 publications were found in preliminary search, and a total of 13 articles met inclusion criteria. A total of 14 participants completed the trial and post-trial questionnaire. Of all responses, 64.29% agreed that the duration of auditory training sessions was reasonable. In addition, 71.43% agreed that the training improved their perception of music. Lastly, 64.29% agreed that the training improved their perception of a primary talker when there are other talkers or background noises present.
Analyzing pellet agglomeration in underwater polymer extrusion pelletizers: a numerical simulation study
Authors: Raj Bebhash S. , Chandy Abhilash J. 
Published: September 2023

Abstract
The production of thermoplastic pellets using underwater die-face pelletizers is a widespread process in the thermoplastics compounding industry. One major challenge in this process is pellet agglomeration, which occurs when the polymer is pliable or easily deformed under heat. To tackle this issue, the non-Newtonian flow of a polymer, along with the turbulent flow of heating oil and heat transfer through the die, are modeled using three-dimensional (3D) computational fluid dynamics (CFD) calculations in ANSYS Fluent. The computational model is validated by comparing its predictions of temperature and pressure using two models with and without a slip method, to experimental measurements from an industrial-scale pelletizer, resulting in a maximum error of <3 % for temperature and <16 % for pressure. The efficiency of the underwater die pelletizer is typically evaluated based on the rate at which it produces pellets. Minor variations in operational parameters, such as the inlet mass flow rate and temperature of the polymer, the temperature of the heating oil, and the water temperature, can greatly affect the quality of the final product. Firstly, contours of pressure, velocity and temperature are presented to understand their impact on pellet agglomeration. However, to more specifically link pellet quality, i.e. pellet agglomeration rate, to the input conditions, the study develops a non-dimensional parameter called the pellet agglomeration number (PAN), as a non-linear function of three other non-dimensional numbers: Reynolds number, Euler number, and a non-dimensional temperature. The values of PAN at the exit and inlet are shown to correlate well with the experimentally measured pellet agglomerations, thereby demonstrating the usefulness of PAN in not only differentiating between good and bad pellet quality but also determining apriori the appropriate operating conditions leading to fewer pellet agglomerations in commercial pelletizers.
Application of indocyanine green in the management of oral cancer: a literature review
Authors: Zhou ChuHuan , Nan XinRong 
Published: September 2023

Abstract
Indocyanine green is a cyanine dye that displays fluorescent properties in the near-infrared region. Indocyanine green has good water solubility and can bind to plasma proteins in the body. After binding, it can display green fluorescence when irradiated by near-infrared fluorescence. Owing to its good imaging ability and low side effects, indocyanine green is widely used in the diagnosis and treatment of various tumors. Indocyanine green-assisted sentinel lymph node biopsy helps determine clean tumor boundaries, helps surgeons remove primary tumors completely, assists in microvascular anastomosis in head and neck repair and reconstruction, reduces operation time, evaluates blood perfusion to monitor flap status. In addition, indocyanine green has great potential in photodynamic therapy to specifically kill tumor cells. However, despite the benefits, studies regarding the application of indocyanine green in oral cancer are limited. Therefore, we conducted a literature review to explore the application of indocyanine green in oral cancer to benefit clinicians involved in the diagnosis and treatment of this disease.
Analysis of Cu and Zn contents in aluminum alloys by femtosecond laser-ablation spark-induced breakdown spectroscopy
Authors: Pinjun Li , Zhengye Xiong , Zidong Ma , Jingyuan Guo , Chunxi Wang 
Published: September 2023

Abstract
To enhance the sensitivity of detecting Cu and Zn in aluminum alloys, we incorporated a spark discharge unit into the femtosecond laser-induced breakdown spectroscopy (fs-LIBS) system, forming a femtosecond laser ablation spark-induced breakdown spectroscopy (fs-LA-SIBS) system. We utilized both fs-LA-SIBS and fs-LIBS techniques to detect Cu and Zn in various aluminum alloy samples with different contents. Our results reveal that the spark discharge extends the duration of laser-induced plasma atomic radiation and amplifies the peak intensity of atomic radiation, thereby significantly increasing the time-integrated signal intensity of laser-induced plasma. Under the present experimental conditions, the limits of detection (LoDs) of Cu and Zn in aluminum alloy by fs-LA-SIBS are 16 and 12 ppm, respectively. In contrast, the LoDs of Cu and Zn by fs-LIBS technique under the same laser pulse energy are 96 and 84 ppm, respectively. Hence, for Cu, the LoDs by the fs-LA-SIBS technique are 1/6 of those by the fs-LIBS technique, and for Zn, the LoDs by the fs-LA-SIBS technique are 1/7 of those by the fs-LIBS technique. Our findings demonstrate that the fs-LA-SIBS technique is more sensitive than the fs-LIBS technique in the quantitative analysis of elements and may be a practical approach for elemental analysis in alloys.
Darío Villamizar Herrera. Crónica de una guerrilla perdida. La historia inédita de la columna del M-19 que desapareció en la selva del Chocó. Bogotá: Debate, 2022. 800 páginas.
Authors: Atehortúa Cruz Adolfo León 
Published: September 2023

El libro consta de dos partes. En la primera de ellas, titulada “El preludio de las armas”, Darío retoma, en cierta forma, la historia del M-19 desde su surgimiento, en enero de 1974, hasta las fallidas propuestas de amnistía formuladas por el gobierno de Turbay Ayala. Este periplo resulta absolutamente necesario para quienes vivimos de alguna manera este devenir e intimamos recordarlo, para quienes no lo siguieron al dedillo y requieren aclarar dudas o completar sus horizontes, para nuevos lectores de la realidad nacional y para una población joven que surge recién a la vida política y ciudadana con la necesidad de conocer este importante trozo de la historia de Colombia y, en particular, el trasegar de la lucha armada revolucionaria, que hace rato conoció su ocaso. La segunda parte del libro describe el escenario al que arribó la guerrilla en el Chocó; la travesía de la columna de la que hacían parte Jorge Iván Rojas, Carmenza Cardona (“La Chiqui”), Édgar Arturo Valencia y Orlando Díaz Otero, participantes en la toma de la Embajada, entre otros; bajo el mando de Hélmer Marín, destacado miembro de la dirección nacional del M-19. Paralelamente, el texto refiere la toma de Mistrató, con sus ventajas y desventajas para la columna que ingresaba y, por último, el desafiante, a veces animado y valiente, pero las más de las veces difícil, desconcertante y desolador itinerario de la que tuvo como nombre “Columna Calarcá” del M-19. En forma consecutiva, el libro de Darío se ocupa igualmente del destino seguido por la columna comandada por Carlos Toledo Plata que penetró al país por Nariño con el propósito de reforzar el Frente Sur del M-19, en donde Jaime Bateman acababa de dirigir la toma de Mocoa. Entre sus consecuencias, señala Darío la ruptura de las relaciones internacionales con Cuba por parte de Colombia y la salida de Gabriel García Márquez del país.
Study of the operating parameters of vibrations of a vibrosieve of the washing liquid purification unit
Authors: Surzhko Tetiana , Knysh Maksym , Kuzub Yurij , Kruchkov Oleksandr , Rubel Vyacheslav 
Published: September 2023

The object of the research is elastic plates located across the movement of the solution on the vibrosieve. The problem of uniform distribution of material on the surface of the sieve is considered, which is solved with the help of the design proposed in the work.
Tensometry was used as a research method with subsequent processing of the results on an elector computer. In the course of the research, an analog-to-digital converter developed and manufactured at the Department of Mechanization of Construction Processes of the National University «Yuri Kondratyuk Poltava Polytechnic» (Ukraine) was used. As well as a computer with a free COM-1 port, «PROGRAM.EXE» software and a spreadsheet editor, strain gauges in the form of strain gauges with two pasted tensor resistors connected by a half-bridge circuit.
The paper proposes a fundamentally new scheme of a vibrosieve with additional working bodies in the form of elastic plates located across the movement of the solution on the sieve. The elasticity and mass of the plates are selected in such a way that their oscillations during the operation of the vibrosieve exciter are close to resonance. At the same time, the mode of vibration of the vibrosieve itself is far beyond resonance. As a result, a higher-quality and energy-efficient cleaning of the washing liquid will be obtained. This is due to the fact that the proposed cleaning method has a number of features, in particular, dispersion of drilling fluid over the entire surface of the vibrosieve and maximum loading of the entire working surface of the sieve to avoid dead zones. Thanks to this, it is possible to obtain resonant oscillations. In comparison with known analogs that work in a resonant mode, this provides advantages in the cleaning of drilling mud. The amplitude of oscillations of elastic plates reaches 1.2–1.5 mm, which is significantly greater than the amplitude of oscillations of a vibrating table.
In practice, it will be possible to use the proposed fundamentally new scheme of a vibrosieve with additional working bodies in the form of elastic plates that work in a resonant mode, as a way of supplementing vibrosieves that are in use or new when manufactured at manufacturers' factories.
Comparative study of the antioxidant properties of organic and inorganic melissa
Authors: Tkachenko Alina 
Published: September 2023

The object of research is organic and inorganic lemon balm. The subject of research is the antioxidant properties of these plants. One of the most problematic areas is that organic products have a slightly different chemical composition, which is due to the lack of fertilizers during their cultivation. The research hypothesis is that organic plants naturally release more phenols and polyphenols, which are needed to fight pests. At the same time, polyphenol compounds have antioxidant properties.
The work investigated the total content of polyphenols in organic and inorganic lemon balm. The content of polyphenols in terms of gallic acid was determined by the spectrophotometric method by reaction with the Folin-Chocalteu reagent. In order to determine the antioxidant properties, the content of the peroxide number and the acid number of the fatty base during storage were determined. As a fat base, a mixture of organic butter and organic rye oil was chosen in a ratio of 75:25. Dried lemon balm was added in the amount of 4 % to the mass of fat. Changes in the fat base were determined in three samples: without the addition of lemon balm, with the addition of dried inorganic and organic lemon balm. The samples were stored in a thermostat at a temperature of 50 °C for 10 days. Studies were conducted every 2 days. The amount of peroxides was determined by the iodometric method. The acid number content was determined every 5 days by the titration method. It has been established that organic lemon balm has better antioxidant properties. This is due to the content of polyphenolic substances. So, the content of polyphenols in ordinary lemon balm is 14.1 mg/g, and in organic – 26.5 mg/g. Research has established that the value of the peroxide number after 10 days of storage was 17 ½O for the sample with the addition of organic lemon balm and 22 ½O for the sample with the addition of ordinary lemon balm. The sample without the addition of lemon balm had a value of 25 ½O. The value of acid number of fat on the tenth day of storage was 1.4 for the sample with the addition of inorganic lemon balm and 1.1 for the sample with the addition of organic lemon balm. Further research is planned to be devoted to the effect of plant organic antioxidants on the lipid fraction of food products.
Doctor Crucis. The Criteria for Conferral of the Title of Doctor of the Church and their Application to the Case of Edith Stein. Part II
Authors: Guerrero van der Meijden Jadwiga 
Published: September 2023

Edith Stein is widely recognised as a saint, a martyr, a victim of the Holocaust and a female philosopher – but can she be a Doctor of the Church? So far, thirty-seven figures, including four women, carry the title due to their so-called ‘eminent doctrines’, eminentes doctrinae. For centuries, a procedural difficulty existed in awarding the titles to martyrs, however, in the second decade of the 21st century, the Congregation for the Causes of Saints reached a conclusion that martyrdom is not, in principle, an obstacle in awarding the title. A question, therefore, can be posed: does the legacy of someone among the Christian martyrs fulfill the criteria of the Church’s Doctorate?
The aim of this article is to investigate the criteria for conferral of the title of the Doctor of the Church, prime among which is a criterion called eminens doctrina, and apply them to one example, that of Edith Stein. In doing so, I consider the question purely historically and philosophically, starting out with definitions of the Father of the Church and the Doctor of the Church in part one (published in June 2023, no 1, p. 131–149). In the second part of the article (available below), I ask what aspects of the female martyr’s theology, philosophy and spirituality fulfill the criteria of an eminent doctrine, as formulated in the Church’s documents, and which are insufficient or lacking. In order to highlight the nature of a particular criterion, I contrast Stein’s case with other recently debated cases, such as those of Irenaeus of Lyons and John Paul II.