bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN DATA MINING UNTUK MENGANALISA POLA PEMBELIAN SAYURAN HIDROPONIK MENGGUNAKAN METODE ALGORITMA APRIORI
Authors: Rahardjo Sugeng Budi , W Wiyanto , Sulistyohati Aprilia , U Umilhuda 
Published: February 2023

Seiring dengan maraknya usaha di bidang sayuran hidroponik, UD. Media Farms menyadari akan munculnya persaingan bisnis yang ketat, sehingga diperlukan strategi untuk menarik konsumen, kurangnya sumber informasi baru menjadi salah satu kendala kemajuan bisnis. Tujuan dari penelitian ini adalah untuk mengetahui informasi mengenai sayuran apa saja yang sering dibeli konsumen secara bersamaan dalam satu kali transaksi guna mengoptimalkan hasil panen sayuran hidroponik dan menentukan strategi bisnis penjualan sayuran hidroponik. Metode data mining yang digunakan dalam penelitian ini adalah metode association rule dengan algoritma apriori. Dari proses pengolahan data menggunakan algoritma aprori dan pengujian dengan alat rapid miner, dengan parameter support minimal 20% dan confidence minimal 60% maka aturan asosiasi yang terbentuk adalah 7 aturan. Dari 7 rule yang terbentuk, ditemukan 3 rule dengan nilai confidence tertinggi yaitu (selada â†’ kangkung) dengan nilai support 50% dan confidence 79%, (selada, bayam merah â†’ kangkung) dengan nilai support 25% dan kepercayaan diri 78%, (selada, pakcoy â†’ kangkung) dengan nilai support 22% dan confidence 76%. Ketiga rule tersebut memiliki nilai lift ratio > 1 yang artinya rule tersebut valid dan dapat digunakan dengan baik.
Anlisa Terpilihnya Tri Rismaharini sebagi Menteri Sosial dengan Pendekatan Algorithma NaÃ¯ve Bayes
Authors: Fatchan Muhamad , Sugeng Hari 
Published: February 2023

Analisis sentimen merupakan penelitian dari suatu pendapat, atau opini dan luapan perasaan yang di ekspresikan dalam bentuk tekstual. Twitter merupakan sosial media yang memiliki jumah pengguna yang banyak khususnya di Indonesia twitter sering digunakan untuk meluapkan perasaan maupun tanggapan opini berupa tanggapan positif maupun negatif. Tujuan dari penelitian ini adalah untuk menentukan sentimen masyarakat terhadap terpilihnya Bu Tri Rismaharini menjadi Menteri Sosial pada twitter serta mengetahui tingkat akurasi metode dalam mengklasifikasikan sentimen positif dan sentimen negatif. Metode yang digunakan dalam penelitian ini yaitu Algoritma NaÃ¯ve Bayes dan pemrosesan data menggunakan aplikasi Rstudio. Hasil dari penelitian ini yaitu mengetahui tingkat akurasi metode NaÃ¯ve Bayes dalam mengklasifikasikan data sentimen positif dan negatif dengan membagi data penelitian menjadi 3 data testing yaitu 30%, 25%, dan 20% dan jumlah akurasi tertinggi yang ada pada penelitian ini adalah data testing 30% dan data training 70% yaitu dengan tingkat akurasi 90,3%. Dari penelitian ini bisa diketahui bahwa menggunakan aplikasi Rstudio dan metode NaÃ¯ve Bayes memiliki tingkat akurasi yang baik dalam menentukan sentiment analisis.
Kata kunci: TNaÃ¯ve Bayes, Analisis sentiment, RStudio, Mensos Risma.
Frequency of Thrombocytopenia in Malaria and its prognostic significance
Authors: Saleh Ahmad  , Saeed-ur-Rehman  , Qazi Ikramullah  , Iqbal Ahmad  
Published: February 2023

BACKGROUND & OBJECTIVE: Thrombocytopenia is a common hematological manifestation of malaria, but locally there is limited data on the association of thrombocytopenia degree and malarial species in Pakistan. Therefore, the present study aims to assess the frequency of thrombocytopenia and its severity among patients with malaria.
METHODOLOGY: In this prospective cross-sectional study, a total of 120 patients with smear-positive for malaria on microscopy were included. The patient's complete blood count (CBC) was assessed daily to monitor the platelet counts, and thrombocytopenia was divided into four categories, i.e., mild, moderate, severe, and very severe thrombocytopenia.
RESULTS: Out of the total 120 malaria-positive cases, 78(65%) were positive for P. vivax, 32(26.7%) were affected by P. falciparum, and 10(8.3%) patients had mixed infection. Thrombocytopenia developed among 73% of the total patients with malaria; of these, 35.23% developed mild thrombocytopenia, while 31.82%, 23.86%, and 9.09% developed moderate, severe, and very severe thrombocytopenia, respectively. Among those 30(34.0%) infected with P. falciparum, 8(26.7%) developed mild thrombocytopenia, while 8(26.7%) and 14(46.7%) developed moderate to very severe thrombocytopenia. Similarly, most patients with P. vivax 23(39.7%) had mild to moderate 20(34.5%) thrombocytopenia, 15(25.9%) had severe, and only 5.19% had very severe thrombocytopenia p-value=0.141 shows non-significant association. Furthermore, P. vivax group developed complications, while two of the four patients of the P. falciparum group developed cerebral malaria, one developed renal failure, and the last one had pancytopenia.
CONCLUSION: In conclusion, thrombocytopenia is frequent among patients with malaria. Moreover, the severity of thrombocytopenia and complications are more evident among those infected with P. falciparum than those with P. vivax.
Three-Pronged Approach to Curb Cancer Metastasis
Authors: Jariya Kalsoom  , Sadaf Naeem  
Published: February 2023

BACKGROUND & OBJECTIVE: Extracellular signal-regulated kinases 1 and 2 [ERK1/2] have been reported to promote cancer spread through receptor tyrosine kinase (RTK)/Ras/Raf/MEK/ERK1/2 pathway hyperactivation. The extracellular signal-regulated kinase ERK5 has also been linked to cancer. However, inhibition of ERK1/2 has been reported to cause compensatory hyperactivation of the ERK5 pathway. Therefore, there is a need for simultaneous inhibition of this trio by a common inhibitor. This study aimed to find a novel common inhibitor for ERK1, ERK2 and ERK5, with a special focus on phytochemicals.
METHODOLOGY: All the available co-crystallized inhibitors of MEK1, ERK1/2 and ERK5 were used as references for 2D search across zillions of compounds. One hundred molecules with the best matching pharmacophores were extracted per virtual chemical space. A total of 20,000 new structurally diverse chemical entities with scaffold hopping ability were sifted out from these chemical spaces. Virtual screening of ERK1/2 and ERK5 was performed against these compounds. The successfully docked molecules with estimated affinities less than 500 nm were filtered. These filtered protein-molecule complexes of ERK1/2 and ERK5 were exported as Excel sheets, which were then compared to find any overlapping inhibitors. Four novel common/overlapping potential inhibitors were identified. Their pose views were generated, and binding interactions were analyzed. These novel compounds were compared for their absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) properties.
RESULTS: The molecules m240690bcc215667167368734, rxn109fEMOL37110279EMOL314046334 and LIND027BT1904LN00213276AK0086 showed good binding affinities to the conventional ATP binding pockets of the kinases ERK1/2 and ERK5.
CONCLUSION: These novel compounds may be proposed as potential common inhibitors of ERK1, 2 and 5. Further in silico analysis and in vitro testing of proteins are required to confirm their inhibitory potential.
ANALISIS PENJUALAN BERSIH DAN BIAYA OPERASIONAL DALAM MENINGKATKAN LABA BERSIH PADA PT. INDUSTRI JAMU DAN FARMASI SIDO MUNCUL TBK PERIODE 2016-2020
Authors: Andini Nurkamilah Rahma , Hamid Edison , Rachmawati  
Published: February 2023

This study aims to determine how Net Sales and Operating Costs increase Net Profit. The research object is PT. Industri Jamu Dan Farmasi Sido Muncul Tbk, Data is taken from the financial statements for the period 2016-2020. This research uses a descriptive qualitative method which consists of three variables, namely net sales and operating costs as independent variables and net income as the dependent variable. The data analysis results show that the average net sales for 5 years are 8.61%. The average operational cost for 5 years is 11.57%. Then from the net sales to increase net profit has an average contribution of 6.25%. And the results of operating costs to increase net profit have a gift of 2.04%. Thus, the results of net sales and operating costs in increasing the total net profit for the last 5 years, namely the 2016-2020 period contributed 8.29% and the rest was contributed by other factors not examined in this study.
ABSTRAK
Penelitian ini bertujuan untuk mengetahui bagaimana Penjualan Bersih dan Biaya Operasi meningkatkan Laba Bersih. Objek penelitian adalah PT. Industri Jamu Dan Farmasi Sido Muncul Tbk, Data diambil dari laporan keuangan periode 2016-2020. Penelitian ini menggunakan metode deskriptif kualitatif yang terdiri dari tiga variabel yaitu penjualan bersih dan biaya operasional sebagai variabel bebas dan laba bersih sebagai variabel terikat. Hasil analisis data menunjukkan bahwa rata-rata penjualan bersih selama 5 tahun adalah 8,61%. Rata-rata biaya operasional selama 5 tahun adalah 11,57%. Kemudian dari penjualan bersih terhadap peningkatan laba bersih memiliki kontribusi rata-rata sebesar 6,25%. Dan hasil biaya operasi untuk meningkatkan laba bersih memiliki hadiah sebesar 2,04%. Dengan demikian hasil penjualan bersih dan biaya operasional dalam meningkatkan total laba bersih selama 5 tahun terakhir yaitu periode 2016-2020 memberikan kontribusi sebesar 8,29% dan sisanya disumbangkan oleh faktor lain yang tidak diteliti dalam penelitian ini.
Cultura organizacional y calidad educativa en las instituciones educativas públicas San Juan Bautista, UGEL Huamanga
Authors: Salcedo Ticlla Marleny , Campana Concha Abelardo Rodolfo , Urbina Graciela 
Published: February 2023

Objetivo: Se consideró como propósito, “analizar la correlación entre la cultura organizacional y la calidad educativa. Materiales y Método: Corresponde a estudio no experimental diseño correlacional, se aplicaron cuestionarios para muestra de 166 profesores. Resultados: Se determinó Rho= 0,687, en las variables estudiadas experimentándose una afirmación mayoritaria entre respuestas a veces adecuado y adecuado, el cual no es lo esperado. De igual manera también se pudo comprobar que las dimensiones de la variable 1 representados por la misión, adaptabilidad, participación y consistencia están relacionadas a la segunda variable, con los siguientes resultados estadísticos Rho = 0.538, 0.468, 0.602, y 0.543, respectivamente. Conclusión: La cultura organizacional se relaciona con la calidad educativa, aunque la primera variable no incide de forma negativa en la segunda variable existe un importante porcentaje que considera lo contrario específicamente en los aspectos que involucra la política.
Variables efectivas; configuración comprensiva y valo-ración de su influencia en la praxis de profesores de excelencia en escuelas públicas de la provincia de Concepción, Chile
Authors: Sanza Vallejos Dra. Gloria , Mendoza Dra. Ana Isabel 
Published: February 2023

Existen variables efectivas que influyen positivamente en la práctica de los profesores y los resultados de aprendizaje (Bruns y Luque, 2014). Este estudio, buscó explorar la configuración comprensiva y la valoración del nivel de influencia de estas variables en la práctica de profesores de excelencia. Estos profesores son reconocidos por sus directivos por sus prácticas en el aula y con la comunidad educativa. Además sobresale la “capacidad de los profesores de asegurarse de que sus alumnos aprendan” (Bruns y Luque, 2014, p.6) obteniendo altos resultados en pruebas estandarizadas en escuelas públicas que albergan estudiantes vulnerables económicamente.
Se seleccionaron 15 docentes de excelencia, trabajando en escuelas públicas de la provincia de Concepción, Chile. Para crear conexión entre la configuración comprensiva de la variables efectivas y la valoración del nivel de influencia de cada una de ellas por parte de los docentes. Se utilizo un método cualitativo mixto de diseño secuencial exploratorio de cuatro fases. Se utilizaron instrumentos cualitativos (entrevista semiestructura, preguntas abiertas y memos analíticos) como cuantitativos (Escala Lickert). Los resultados demostraron que para los docentes de excelencia todas las variables efectivas estudiadas son altamente influyentes en su praxis por su atributo de colaboración directa con el aprendizaje. Teniendo mayor valoración de influencia las variables consideradas internas; ambiente de aula y altas expectativas sobre los estudiantes. Les siguen en nivel de influencia: condiciones laborales, liderazgo directivo, desarrollo profesional, trabajo con apoderados y entre pares. Consideradas variables externas, puesto que en la praxis de éstas también participan e influencian otros actores.
AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KELOR METODE DPPH DAN FRAP SEBAGAI SEDIAAN OBAT DAN MAKANAN
Authors: Suriawati Junie , Siti Rahayu Rachmawati  
Published: February 2023

Daun kelor banyak dibudidayakan oleh masyarakat karena diyakini dapat memberikan banyak manfaat, antara lain bidang farmasi dan makanan. Ekstrak daun kelor (Moringa oleifera L.) mengandung senyawa alkaloid, flavonoid, fenolat, triterpenoida/steroida, dan tanin yang berfungsi sebagai antioksidan. Senyawa zat aktif pada daun kelor dapat diperoleh dengan cara ekstraksi menggunakan pelarut air, karena pelarut air dapat diaplikasikan ke masyarakat sebagai sediaan yang aman untuk dikonsumsi. Umumnya penelitian ekstrak daun kelor menggunakan pelarut air dengan cara infusa atau pelarut organik. Penelitian ekstrak daun kelor yang diperoleh dengan cara pemerasan belum pernah dilakukan, terutama aktivitas antioksidan. Tujuan dari penelitian adalah untuk mengetahui aktivitas antioksidan ekstrak daun kelor dengan metode DPPH dan FRAP sebagai sediaan obat dan makanan. Uji aktivitas antioksidan dilakukan dengan metode 2,2-difenil-I-pikrilhidrazil/DPPH serta metode aktivitas potensial reduksi besi (Ferric Reduction Antioxidant Power/FRAP) yang masing masing memiliki kelebihan pada metodenya. Hasil penelitian ekstrak daun kelor infusa dan pemerasan memiliki kadar fenol total 50,10331±0,005 mg GAE/g dan 47,55012±0,019 mg GAE/g sedangkan kadar flavonoid total 36,56286±0,026 mg QE/g dan 37,76643±0,025 mg QE/g. IC50 ekstrak daun kelor infusa dan pemerasan dengan metode DPPH sebesar 4,12 ppm dan 26,13 ppm serta IC50 ekstrak daun kelor infusa dan pemerasan dengan metode FRAP adalah 11140,06 ppm dan 21529,00 ppm. Berdasarkan hasil tersebut dapat disimpulkan ekstrak daun kelor dengan metode DPPH memiliki aktivitas antioksidan kuat dan metode FRAP memiliki aktivitas antioksidan lemah, sehingga ekstrak daun kelor tersebut dapat digunakan sebagai sediaan obat dan makanan.
Kata kunci : daun kelor, antioksidan, sediaan obat dan makanan
Detecting Exomoons from Radial Velocity Measurements of Self-luminous Planets: Application to Observations of HR 7672 B and Future Prospects
Authors: Ruffio Jean-Baptiste , Horstman Katelyn , Mawet Dimitri , Rosenthal Lee J. , Batygin Konstantin , Wang 王 Jason J. 劲飞 , Millar-Blanchaer Maxwell , Wang 王 Ji 吉 , Fulton Benjamin J. , Konopacky Quinn M. , Agrawal Shubh , Hirsch Lea A. , Howard Andrew W. , Blunt Sarah , Nielsen Eric , Baker Ashley , Bartos Randall , Bond Charlotte Z. , Calvin Benjamin , Cetre Sylvain , Delorme Jacques-Robert , Doppmann Greg , Echeverri Daniel , Finnerty Luke , Fitzgerald Michael P. , Jovanovic Nemanja , López Ronald , Martin Emily C. , Morris Evan , Pezzato Jacklyn , Ruane Garreth , Sappey Ben , Schofield Tobias , Skemer Andrew , Venenciano Taylor , Wallace J. Kent , Wallack Nicole L. , Wizinowich Peter , Xuan Jerry W. 
Published: February 2023

Abstract
The detection of satellites around extrasolar planets, so called exomoons, remains a largely unexplored territory. In this work, we study the potential of detecting these elusive objects from radial velocity monitoring of self-luminous, directly imaged planets. This technique is now possible thanks to the development of dedicated instruments combining the power of high-resolution spectroscopy and high-contrast imaging. First, we demonstrate a sensitivity to satellites with a mass ratio of 1%–4% at separations similar to the Galilean moons from observations of a brown-dwarf companion (HR 7672 B; K
mag = 13; 0.″7 separation) with the Keck Planet Imager and Characterizer (R ∼ 35,000 in the K band) at the W. M. Keck Observatory. Current instrumentation is therefore already sensitive to large unresolved satellites that could be forming from gravitational instability akin to binary star formation. Using end-to-end simulations, we then estimate that future instruments such as the Multi-Object Diffraction-limited High-resolution Infrared Spectrograph, planned for the Thirty Meter Telescope, should be sensitive to satellites with mass ratios of ∼10−4. Such small moons would likely form in a circumplanetary disk similar to the Jovian satellites in the solar system. Looking for the Rossiter–McLaughlin effect could also be an interesting pathway to detecting the smallest moons on short orbital periods. Future exomoon discoveries will allow precise mass measurements of the substellar companions that they orbit and provide key insight into the formation of exoplanets. They would also help constrain the population of habitable Earth-sized moons orbiting gas giants in the habitable zone of their stars.
AAPOS Adult Strabismus Committee's Report on the Status of Adult Strabismus Telemedicine
Authors: Vagge Aldo , Roda Matilde , Valsecchi Nicola , Capo Hilda , Schiavi Costantino , Velez Federico G. ,   the AAPOS Adult Strabismus Committee
Published: February 2023

Purpose:
To evaluate the utility of telemedicine in the treatment of adult patients with strabismus.

Methods:
A 27-question online survey was sent to ophthalmologists of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) Adult Strabismus Committee. The questionnaire focused on the frequency of telemedicine utilization, the benefits in the diagnosis, follow-up, and treatment of adult strabismus, and barriers of current forms of remote patient visits.

Results:
The survey was completed by 16 of 19 members of the committee. Most respondents (93.8%) reported 0 to 2 years of experience with telemedicine. Telemedicine was found to be useful for initial screening and follow-up of established patients with adult strabismus, mainly to reduce wait time for a subspecialist visit (46.7%). A successful telemedicine visit could be completed with a basic laptop (73.3%) or a camera (26.7%) or could be assisted by an orthoptist. Most participants agreed that common forms of adult strabismus (cranial nerve palsies, sagging eye syndrome, myogenic strabismus, and thyroid ophthalmopathy) could be examined via webcam. It was easier to analyze horizontal than vertical strabismus. Among the paralytic forms, sixth nerve palsy was the easiest one to assess. Latent forms of strabismus can be partially diagnosed and evaluated using telemedicine, but half of the respondents underlined the importance of in-person examinations in these cases. Sixty-nine percent believed that telemedicine could be a low-cost and time-efficient health service solution.

Conclusions:
Most members of the AAPOS Adult Strabismus Committee consider telemedicine to be a useful supplement to the current adult strabismus practice.

[
J Pediatr Ophthalmol Strabismus
. 2023;60(6):386–389.]
Evaluation of Voice Handicap and Emotional Status among Dysphonic and Non-Dysphonic Individuals
Authors: Adamu Auwal , Jibril Yasir Nuhu , Kolo Emmanuel Sara , Aluko AbdulAkeem Adebayo , Bello-Muhammad Nafisatu , Ajiya Abdulrazak , Shuaibu Iliyasu Yunusa 
Published: February 2023

Background:
Dysphonia impairs verbal communication of the sufferer, which can lead to social isolation, depression, and reduced quality of life. Evaluation of voice handicap and emotional impact of dysphonia are not routinely consider in our laryngology and voice clinics, despite the fact that about 50% to 60% of patients with dysphonia have social and psychological problems.

Aims:
The aim of this study is to investigate the voice handicap and emotional status among dysphonic and non-dysphonic individuals in our environment.

Materials and Methods:
It was a cross-sectional study that included dysphonic patients and non-dysphonic individuals matched for age and gender. A detailed clinical history was obtained, and the Voice Handicap Index (VHI) questionnaire was used to assess the voice handicap and emotional status of the participants. The mean VHI score of dysphonic and non-dysphonic participants was compared.

Results:
Ninety dysphonic patients and equal number of non-dysphonic controls completed the study. The mean VHI score dysphonic patients was higher (46.8 ± 17.7) than that of the controls (5.2 ± 3.9), and there was a statistical significant difference between the two groups (P = 0.000). Most of the dysphonic patients 69(77.8%) had poor emotional status, while most of the controls had good emotional status 83(92.3%).

Conclusion:
This study found high Voice Handicap Index and poor emotional status among dysphonic patients compared to controls. Therefore, patients with dysphonia should be reviewed by a psychologist in order to address the emotional aspect of their problem.
Orthopedic implant hypersensitivity: Characterization of clinical presentation and effects of photobiomodulation therapy
Authors: Wu Ro-Wei , Chang Chung-Hsing 
Published: February 2023

ABSTRACT

Objectives:
Orthopedic implants have improved the quality of life in aging society but also induces several kinds of tissue reactions, referred to as orthopedic implant hypersensitivity (OIH). The aim of our study is to report the clinical characteristics of OIH and the effects of photobiomodulation therapy (PBMT) on these groups of patients.

Materials and Methods:
We collected cases that complained of skin rashes with pruritus after orthopedic implants from January 2017 to June 2022 at the Dermatology clinic in Hualien Tzu Chi Hospital. We recorded the sites and material of orthopedic implants, skin lesions onset time, symptoms, location after implantation, and the disease duration. Laboratory tests were measured, including complete blood count, differential count, serum immunoglobulin E (IgE) level, as well as inflammatory and autoimmune markers. PBMT, including UVB311 nm or low-level laser therapy 808 nm, was performed. Dose, duration, and response were documented.

Results:
Fourteen patients were diagnosed with OIH; twelve presented with localized eczema at the implant sites, and two with generalized eczema. Eleven patients (78.6%) had either elevated eosinophils percentage (>6%) or IgE level (>200 U/mL) or both. Seven patients (50%) had favorable outcome after PBMT and successfully withdrew from systemic steroid.

Conclusion:
In our case series, localized eczema at implant sites was a common cutaneous presentation in OIH. Hence, a surgical scar at the eczema site or long-term waxing and waning generalized eczema should prompt physicians on the possibility of OIH. Blood eosinophils percentage and serum IgE level can be reference biomarkers for OIH. PBMT provides a noninvasive and effective treatment strategy for immune regulation and tissue regeneration.