bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring support, experiences and needs of older women and health professionals to inform a self-management package for urinary incontinence: a qualitative study
Authors: Fu Yu , Jackson Cath , Nelson Andrea , Iles-Smith Heather , McGowan Linda 
Published: July 2023

ObjectivesMany women attempt to manage urinary incontinence (UI) independently with variable success while health professionals may be unaware of their needs. This study aimed to (1) understand older women’s experiences of UI, their self-management strategies and support needs; (2) explore health professionals’ experiences of supporting women and providing relevant services and (3) combine their experiences contribute to development of a theory-based and evidence-based self-management package for UI.DesignQualitative semi-structured interviews were conducted with 11 older women with UI and 11 specialist health professionals. Data were analysed independently using the framework approach, then synthesised in a triangulation matrix to identify implications for content and delivery of the self-management package.SettingCommunity centres, community continence clinic and urogynaecology centre of a local teaching hospital in northern England.ParticipantsWomen aged 55 years and over who self-reported symptoms of UI and health professionals delivering UI services.ResultsThree overarching themes emerged. Older women see UI as a ‘fact of life’ but many struggle with it: women typically considered UI as part of ageing yet expressed annoyance, distress, embarrassment and had made significant lifestyle changes. Access to information and limited high-quality professional support: health professionals provided specialist UI care and information. Yet less than half of women accessed specialist services, those who had, highly valued these services. ‘Trial and error’ with different self-management strategies: women had tried or were using different strategies (continence pads, pelvic floor exercises, bladder management and training, fluid management and medication), with mixed success. Health professionals provided evidence-based, personalised support and motivation.ConclusionsFindings informed the content of the self-management package that focused on providing facts, acknowledging challenges of living with/self-managing UI, sharing others’ experiences, using motivational strategies and self-management tools. Delivery preferences were independent use by women or working through the package with a health professional.
Combination of cancer vaccine with CD122-biased IL-2/anti-IL-2 Ab complex shapes the stem-like effector NK and CD8+T cells against tumor
Authors: Shimizu Kanako , Ueda Shogo , Kawamura Masami , Aoshima Honoka , Satoh Mikiko , Nakabayashi Jun , Fujii Shin-ichiro 
Published: July 2023

BackgroundA key to success of cancer immunotherapy is the amplification and sustenance of various effector cells. The hallmark of prominent antitumor T cells is their long-term effector function. Although interleukin (IL)-2 is an attractive cytokine, several attempts have been made towards developing IL-2 modalities with improved effectiveness and safety that enhance natural killer (NK) cells or T cells in cancer models. However, whether such IL-2 modalities can simultaneously support long-term innate and adaptive immunity, particularly stem-like memory, has not been shown. To resolve this issue, we compared the antitumor cellular mechanism with two IL-2/anti-IL-2 complexes (IL-2Cxs) administered in combination with a therapeutic cancer vaccine, which we had previously established as an in vivo dendritic cell-targeting therapy.MethodsTwo types of IL-2Cxs, CD25-biased IL-2Cx and CD122-biased IL-2Cx, together with a Wilms’ tumor 1-expressing vaccine, were evaluated in a leukemic model. The immunological response and synergistic antitumor efficacy of these IL-2Cxs were then evaluated.ResultsWhen CD25-biased or CD122-biased IL-2Cxs in combination with the vaccine were assessed in an advanced-leukemia model, the CD122-biased IL-2Cx combination showed 100% survival, but the CD25-biased IL-2Cx did not. We first showed that invariant natural killer T (NKT) 1 cells are predominantly activated by CD122-biased IL-2Cx. In addition, in-depth analysis of immune responses by CD122-biased IL-2Cx in lymphoid tissues and the tumor microenvironment revealed a dramatic increase in the distinct subsets of NK and CD8+T cells with stem-like phenotype (CD27+Sca-1hi, CXCR3hi, CD127+TCF-1+T-bet+Eomes+). Moreover, CD122-biased IL-2Cx combination therapy maintained long-term memory CD8+T cells capable of potent antitumor protection. After the high dimensional profiling analysis of NK and CD8+T cells, principal component analysis revealed that the stem-like-NK cell and stem-like-CD8+T cell state in the combination were integrated in the same group.ConclusionsCD122-biased IL-2Cx combined with the vaccine can induce a series of reactions in the immune cascade, including activation of not only NKT1 cells, but also NK and CD8+T cells with a stem-like memory phenotype. Since it can also lead to a long-term, strong antitumor response, the combination of CD122-biased IL-2Cx with a vaccine may serve as a potential and competent strategy for patients with advanced cancer.
Haemostatic resuscitation in practice: a descriptive analysis of blood products administered during Operation HERRICK, Afghanistan
Authors: Davies Rhys L , Thompson J , McGuire R , Smith J E , Webster S , Woolley T 
Published: July 2023

IntroductionLife-threatening haemorrhage is the leading cause of potentially survivable injury in battlefield casualties. During Operation HERRICK (Afghanistan), mortality rates improved year on year due to a number of advances in trauma care, including haemostatic resuscitation. Blood transfusion practice has not previously been reported in detail during this period.MethodsA retrospective analysis of blood transfusion at the UK role 3 medical treatment facility (MTF) at Camp Bastion between March 2006 and September 2014 was performed. Data were extracted from two sources: the UK Joint Theatre Trauma Registry (JTTR) and the newly established Deployed Blood Transfusion Database (DBTD).Results3840 casualties were transfused 72 138 units of blood and blood products. 2709 adult casualties (71%) were fully linked with JTTR data and were transfused a total of 59 842 units. Casualties received between 1 unit and 264 units of blood product with a median of 13 units per patient. Casualties wounded by explosion required almost twice the volume of blood product transfusion as those wounded by small arms fire or in a motor vehicle collision (18 units, 9 units, and 10 units, respectively). More than half of blood products were transfused within the first 2 hours following arrival at the MTF. There was a trend towards balanced resuscitation with more equal ratios of blood and blood products being used over time.ConclusionThis study has defined the epidemiology of blood transfusion practice during Operation HERRICK. The DBTD is the largest combined trauma database of its kind. It will ensure that lessons learnt during this period are defined and not forgotten; it should also allow further research questions to be answered in this important area of resuscitation practice.
Abdominal aortic junctional tourniquet (AAJT-S): a systematic review of utility in military practice
Authors: Webster Stacey , Ritson J E , Barnard E B G 
Published: July 2023

IntroductionHaemorrhage is the leading cause of potentially survivable death on the battlefield. Despite overall improvement in battlefield mortality, there has been no improvement in survival following non-compressible torso haemorrhage (NCTH). The abdominal aortic junctional tourniquet-stabilised (AAJT-S) is a potential solution that may address this gap in improving combat mortality. This systematic review examines the evidence base for the safety and utility of the AAJT-S for prehospital haemorrhage control in the combat setting.MethodsA systematic search of MEDLINE, Cumulated Index to Nursing and Allied Health Literature and Embase (inception to February 2022) was performed using exhaustive terms, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. The search was limited to English-language publications in peer-reviewed journals; grey literature was not included. Human, animal and experimental studies were included. Papers were reviewed by all authors to determine inclusion. Each study was assessed for level of evidence and bias.Results14 studies met the inclusion criteria: 7 controlled swine studies (total n=166), 5 healthy human volunteer cases series (total n=251), 1 human case report and 1 mannikin study. The AAJT-S was demonstrated to be effective at cessation of blood flow when tolerated in healthy human and animal studies. It was easy to apply by minimally trained individuals. Complications were observed in animal studies, most frequently ischaemia-reperfusion injury, which was dependent on application duration. There were no randomised controlled trials, and the overall evidence base supporting the AAJT-S was low.ConclusionsThere are limited data of safety and effectiveness of the AAJT-S. However, there is a requirement for a far-forward solution to improve NCTH outcomes, the AAJT-S is an attractive option and high-quality evidence is unlikely to be reported in the near future. Therefore, if this is implemented into clinical practice without a solid evidence base it will need a robust governance and surveillance process, similar to resuscitative endovascular balloon occlusion of the aorta, with regular audit of use.
Effect of spousal military deployment during pregnancy on neonatal birth outcomes: a systematic review
Authors: Morris Kirsten 
Published: July 2023

IntroductionStress experienced during pregnancy is associated with adverse birth outcomes including preterm delivery (PTD) and low birth weight (LBW). Pregnant spouses and partners of deployed military personnel can experience heightened stress due to several factors associated with the military lifestyle. This systematic review aims to ascertain whether deployment at the time of delivery increases the risk of PTD and/or LBW in babies born to pregnant spouses or partners of deployed service persons.MethodsA systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses method by searching EMBASE, Medline, PubMed and Global Health databases from inception to March 2021. Keyword searches were used to identify primary research, English language journal articles, that included any military branch and reported a measure of PTD and/or LBW of babies born to spouses/partners of deployed service persons. Risk of bias was assessed with validated tools appropriate for study type and a narrative synthesis was performed.ResultsThree cohort or cross-sectional studies fulfilled the eligibility criteria. All three studies were conducted in the US military, were published between 2005 and 2016 and included a cumulative total of 11 028 participants. Evidence suggests that spousal deployment may be a risk factor for PTD, although strength of evidence is weak. No association between spousal deployment and LBW was found.ConclusionPregnant spouses and partners of deployed military personnel may be at increased risk of PTD. The strength of evidence is limited by a paucity of rigorous research in this area. No studies were identified that included service women in the UK Armed Forces. Further research is required to understand the perinatal needs of pregnant spouses/partners of deployed service persons and to understand if there are unmet clinical or social needs in this population.
Unresectable hepatocellular carcinoma: transarterial chemoembolisation plus Huachansu – a single-center randomised controlled trial
Authors: Gao Huifeng , He Jian , Cheng Chien-shan , Zhuang Liping , Chen Hao , Meng Zhiqiang 
Published: July 2023

ObjectiveHuachansu, a Chinese medicine derived from the dried skin glands of toad venom, has been used in China since the 1970s to treat liver cancer. Transarterial chemoembolisation (TACE) is the standard of care for patients with unresectable hepatocellular carcinoma (HCC). This study evaluated the efficacy and safety of the combination of TACE and Huachansu in unresectable HCC.MethodsFrom September 2012 to September 2016, 120 patients diagnosed with unresectable HCC were prospectively enrolled. Patients were randomised at a 1:1 ratio into the combined treatment group (Huachansu–TACE) and the TACE treatment group. The primary endpoint was progression-free survival (PFS) and secondary endpoints were overall survival (OS) and safety. The exploration outcome serum Na+/K+-ATPase (NKA) α3 at baseline and 3-month follow-ups were compared for a prognostic role. All patients were subjected to 36-month follow-up.ResultsA total of 112 patients who completed the study were included in the analysis. PFS and OS were significantly better in the Huachansu–TACE group than in the TACE group (p=0.029 and p=0.025, respectively), with a median PFS of 6.8 and 5.3; and a median OS of 14.8 months and 10.7 months, respectively. Although no prognostic significance was found between the baseline NKA-low and NKA-high groups in the patients’ OS (p=0.48), its changes after 3-month follow-up showed significant prognostic values, of which, were 8.5 months and 23.8 months, respectively (p<0.001). Treatment-related adverse events were comparable between groups.ConclusionsHuachansu–TACE is effective in prolonging the PFS and OS in patients with unresectable HCC.Trial registration numberNCT01715532.
Searching for anomalous quartic gauge couplings at muon colliders using principal component analysis
Authors: Dong Yi-Fei , Mao Ying-Chen , Yang Ji-Chong 
Published: July 2023

AbstractSearching for new physics (NP) is one of the areas of high-energy physics that requires the most processing of large amounts of data. At the same time, quantum computing has huge potential advantages when dealing with large amounts of data. The principal component analysis (PCA) algorithm may be one of the bridges connecting these two aspects. On the one hand, it can be used for anomaly detection, and on the other hand, there are corresponding quantum algorithms for PCA. In this paper, we investigate how to use PCA to search for NP. Taking the example of anomalous quartic gauge couplings in the tri-photon process at muon colliders, we find that PCA can be used to search for NP. Compared with the traditional event selection strategy, the expected constraints on the operator coefficients obtained by PCA based event selection strategy are even better.
Nematicidal and antioxidant activities of the methanolic extract from Tithonia diversifolia grown in Vietnam
Authors: Nguyen Dang-Minh-Chanh , Luong Thi-Hoan , Nguyen Xuan-Hoa , Jung Woo-Jin 
Published: July 2023

Summary
This study aimed to evaluate the nematicidal activity of the Tithonia diversifolia leaf extract (TDE) against Meloidogyne incognita under in vitro and pot conditions. In addition, the antioxidant activity of TDE was evaluated using the 2,2-Diphenyl-2-picrylhydrazyl hydrate (DPPH) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The results revealed that TDE possesses antioxidant potential. Nematicidal activity bioassays revealed that the TDE treatment resulted in 3.0, 16.3, 36.6, 52.4 and 64.2% second-stage juvenile (J2) hatch inhibition at MeOH control, 0.125, 0.25, 0.5 and 1.0 mg ml−1, respectively, for a 5-day treatment. The corresponding values for a 10-day treatment were 3.3, 16.0, 30.7, 56.0 and 69.3%, respectively. The TDE treatment resulted in 64.6, 86.4, 95.3 and 100% J2 movement inhibition at 0.125, 0.25, 0.5 and 1.0 mg ml−1, respectively, for a 48 h treatment. In pot experiments, at 60 days after treatment (DAT), the J2 populations in non-treated, 0.25, 0.5, 1.0 mg TDE (g soil)−1, and Tervigo 020SC 1.0 mg (g soil)−1 were 477.1, 277.3, 142.7, 23.9 and 19.7 per 5 g of root, respectively. The corresponding values in 100 g of soil were 33.2, 5.5, 3.6, 1.1 and 4.0, respectively. The relative galling formation on the Robusta coffee plants was 100, 55.3, 39.1, 33.5 and 80.8% in the non-treated, 0.25, 0.5, 1.0 mg TDE (g soil)−1, and Tervigo-treated plants, respectively. These results may provide crucial information for exploring the nematicidal metabolites of TDE against M. incognita. Therefore, the purified active compounds of TDE should be identified in future studies before the commercialisation of TDE for the biocontrol of M. incognita.
Dirty Hands Defended
Authors: Eggert Linda 
Published: July 2023

Abstract
This paper defends the possibility of dirty hands against the longstanding skepticism that an action cannot be simultaneously right and wrong and that dirty hands cases are therefore impossible. While skeptics are right to recognize that prima facie reasons against violating moral duties may be overridden, they are wrong to deny that actions required by necessity may nevertheless remain wrong. Dirty hands cases capture the simultaneous necessity of disregarding moral duties in certain circumstances and the reprehensibility of wronging people even in cases in which this is all-things-considered permissible. Rather than indicating any deficiency in our moral reasoning, the capacity to accommodate the possibility of dirty hands, along with the reality of moral conflict, is a strength of a moral theory.
Jóhann Páll Árnason: A Pražák
Authors: Dunaj Ľubomír 
Published: July 2023

Abstract
The “Czechoslovakian Sixties” can be described as the culmination of an incredible intellectual activity. Jóhann P. Árnason spent this time as a student at Charles University in Prague, deeply immersed in the Czech and Slovak intellectual life. This article claims that his personal experience with “Czechoslovakian (Hi)Story,” as well as with its intellectual reflections, significantly influenced the development of his socio-theoretical point of view. However, this ambitious claim will be confined to only three foci. First, Jóhann Árnason will be placed into the Czechoslovakian context. By this, the intellectual and artistic achievements of the 1960s will be put into contrast with the creative “impotence” of the 1990s, which, inter alia, is a consequence of the dominance of the transitological approach in political and social sciences at that time (i.). This approach is strongly criticized across the paper, especially in the second part, introducing Boris Buden’s critique of it (ii.) Finally, that “intellectual impotence” will be explained by using Árnason’s reading of Jan Patočka’s text Supercivilization and its Inner Conflict (iii.).
Atmospheric Response to a Collapse of the North Atlantic Circulation under a Mid-Range Future Climate Scenario: A Regime Shift in Northern Hemisphere Dynamics
Authors: Orbe Clara , Rind David , Miller Ron L. , Nazarenko Larissa S. , Romanou Anastasia , Jonas Jeffrey , Russell Gary L. , Kelley Maxwell , Schmidt Gavin A. 
Published: July 2023

Abstract
Climate models project a future weakening of the Atlantic meridional overturning circulation (AMOC), but the impacts of this weakening on climate remain highly uncertain. A key challenge in quantifying the impact of an AMOC decline is in isolating its influence on climate, relative to other changes associated with increased greenhouse gases. Here we isolate the climate impacts of a weakened AMOC in the broader context of a warming climate using a unique ensemble of Shared Socioeconomic Pathway (SSP) 2–4.5 integrations that was performed using the Climate Model Intercomparison Project phase 6 (CMIP6) version of the NASA Goddard Institute for Space Studies ModelE (E2.1). In these runs internal variability alone results in a spontaneous bifurcation of the ocean flow, wherein 2 out of 10 ensemble members exhibit an entire AMOC collapse, while the other 8 members recover at various stages despite identical forcing of each ensemble member and with no externally prescribed freshwater perturbation. We show that an AMOC collapse results in an abrupt northward shift and strengthening of the Northern Hemisphere (NH) Hadley cell (HC) and intensification of the northern midlatitude eddy-driven jet. We then use a set of coupled atmosphere–ocean abrupt CO2 experiments spanning the range 1 times to 5 times CO2 (1x to 5xCO2) to show that this response to an AMOC collapse results in a nonlinear shift in the NH circulation moving from 2xCO2 to 3xCO2. Slab-ocean versions of these experiments, by comparison, do not capture this nonlinear behavior. Our results suggest that changes in ocean heat flux convergences associated with an AMOC collapse—while highly uncertain—can result in profound changes in the NH circulation and continued efforts to constrain the AMOC response to future climate change are needed.
Old dog, new tricks? Exploring the potential functionalities of ChatGPT in supporting educational methods in social psychiatry
Authors: Smith Alexander , Hachen Stefanie , Schleifer Roman , Bhugra Dinesh , Buadze Anna , Liebrenz Michael 
Published: July 2023

Background: Artificial Intelligence is ever-expanding and large-language models are increasingly shaping teaching and learning experiences. ChatGPT is a prominent recent example of this technology and has generated much debate around the benefits and disadvantages of chatbots in educational domains. Aim: This study seeks to demonstrate the possible use-cases of ChatGPT in supporting educational methods specific to social psychiatry. Methods: Through interactions with ChatGPT 3.5, we asked this technology to list six ways in which it could aid social psychiatry teaching. Subsequently, we requested that ChatGPT perform one of the tasks it identified in its responses. Findings: ChatGPT highlighted several roles it could fulfil in educational settings, including as an information provider, a tool for debates and discussions, a facilitator of self-directed learning and a content-creator for course materials. For the latter scenario, based on another prompt, ChatGPT generated a hypothetical case vignette for a topic relevant to social psychiatry. Conclusions: Based on our experiences, ChatGPT can be an effective teaching tool, offering opportunities for active and case-based learning for students and instructors in social psychiatry. However, in their current form, chatbots have several limitations that must be considered, including misinformation and inherent biases, although these may only be temporary in nature as these technologies continue to advance. Accordingly, we argue that large-language models can support social psychiatry education with appropriate caution and encourage educators to become attuned to their potential through further detailed research in this area.
Investigation of Phenylbutazone in Synovial Fluid
Authors: Farr Margaret , Willis J V 
Published: July 2023

1. Phenylbutazone was measured in the synovial fluid of 15 patients and found to be present in appreciable amounts which were related to plasma levels. 2. 80% of fluid levels were between 55% and 80% of those in plasma. 3. There was some evidence that in very actively inflamed joints phenylbutazone levels were lower. 4. There was no relationship to plasma or synovial fluid protein levels. 5. Phenylbutazone was found in one patient's synovial fluid three weeks after stopping the drug.
Effects of Anti-Inflammatory Drugs on Serum Chemistry
Authors: Kendall M J 
Published: July 2023

1. Biochemical abnormalities are frequently observed when the sera of rheumatoid patients are analyzed. 2. The serum cholesterol, bilirubin, glucose and proteins are significantly related to the activity of the disease. 3. The possible effects of drug therapy are discussed and described. It seems that the way in which drugs modify a patient's serum chemistry may be used to assess the efficacy with which they control the inflammatory process.