bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudo anatômico do Filum Terminalis: dissecção de 31 cadáveres
Authors: Pinto Fernando C. G. , Fontes Ricardo B. de V. , Leonhardt Marcos de Camargo , Amodio Daniel Tasseto , Porro Fabrício Frutos , Machado Jorge 
Published: March 2023

Descrever a anatomia intradural do filum terminalis (FT) e relacionar sua origem, comprimento e inserção com a coluna lombar e sacral em 31 cadáveres de adultos sem patologias da coluna, visando acesso cirúrgico para a porção inferior intradural do FT. Métodos: Foram realizadas 31 dissecções em cadáveres frescos no Sistema de Verificação de Óbitos da Capital de São Paulo no período de março de 2000 a janeiro de 2001. A anatomia do filum terminalis foi estudada através de ampla laminectomia tóraco-lombo-sacral, identificando o nível de origem e inserção (porção superior, média ou inferior da vértebra ou espaço intervertebral em questão), comprimento e diâmetros na sua origem e terço médio. Resultados: Treze (42,0%) FT apresentaram origem em L1, sete (22,5%) em L2, cinco (16,1%) em T12, dois (6,5%) em L1-L2, dois (6,5%) em L2-L3, um (3,2%) em T12-L1 e um (3,2%) em T11. Dezoito (58,1%) FT apresentaram inserção em S2, cinco (16,1%) em S1, cinco (16,1%) em S3, dois (6.5%) em S2-S3 e um (3,2%) S1-S2. A média dos comprimentos aferidos da origem até a inserção do filum terminalis foi 158,86 mm, variando de 112,80 a 211,10 mm. A média dos diâmetros, na sua origem e terço médio, foram 1,36 mm e 0,72 mm, variando de 0,35 a 2,50 mm e 0,10 a 1,55 mm, respectivamente. Conclusões: Em nosso estudo, a maioria dos FT apresentou origem em L1 (42,0%) e inserção dural em S2 (58,1%), 16,1% apresentaram inserção em S1; dessa forma para devida exposição cirúrgica do filum terminalis na sua porção livre não inserida na dura-máter, além de laminectomia de S1, torna-se prudente a realização adicional de laminectomia parcial ou total de L5.
Tratamento cirúrgico funcional da dor
Authors: Teixeira Manoel Jacobsen , Haman Clement , Teixeira William Gemio Jacobsen 
Published: March 2023

Vários são os procedimentos cirúrgicos funcionais destinados ao tratamento da dor resultante de afecções músculoesqueléticas. A descompressão de estruturas nervosas tronculares ou radiculares angustiadas em decorrência de afecções inflamatórias, degenerativas, oncológicas, deformidades ósseas ou fraturas do aparelho locomotor pode proporcionar alívio de dores neuropáticas. Os procedimentos neurocirúrgicos funcionais ablativos são indicados em casos de dor por nocicepção, cuja indicação é restrita a doentes que apresentem perspectivas de sobrevida prolongada. A simpatectomia é pouco eficaz em casos de síndrome complexa de dor regional do tipo II; as neurotomias dos ramos recorrentes posteriores das raízes espinais são úteis no tratamento da cervicalgia, dorsalgia elombalgia de natureza miofascial; a lesão do trato de Lissauer é indicada em casos de dor neruropática e de espasticidade; a mesencefalotomia, as talamotomias e a psicocirurgia são indicadas em casos rebeldes aos tratamentos convencionais. As cordotomias, as rizotomias e as mielopatias não são indicadas em doentes com dor músculo-esquelética. Os procedimentos endocrinológicos incluindo a hipofisectomia são úteis no tratamento da dor decorrente de metástases ósseas especialmente do carcinoma de mama, próstata ou endométrio. A estimulação elétrica do sistema nervoso central geralmente não proporciona alívio nos doentes que apresentam dormúsculo-esquelética, exceto, em casos de síndrome pós-laminectomia. A infusão de fármacos analgésicos no compartimento espinal ou no compartimento ventricular é eficaz no tratamento da maioria dos casos.
Effect on cardiac function among patients with type 2 diabetes following high-dose mineralocorticoid receptor antagonist using echocardiography; data from the MIRAD randomized clinical trial
Authors: H. Brandt-Jacobsen Niels , Johansen Marie Louise , Rasmussen Jon J. , Dalsgaard Morten , Kumler Thomas , Faber Jens , Rossignol Patrick , Schou Morten , Kistorp Caroline 
Published: March 2023

Abstract
Background
Early heart failure prevention is central in patients with type 2 diabetes, and mineralocorticoid receptor antagonists (MRAs) have shown to improve prognosis. We investigated the effect of high-dose MRA, eplerenone, on cardiac function and structure in patients with type 2 diabetes and established or increased risk of cardiovascular disease but without heart failure.

Methods
In the current randomized, placebo-controlled clinical trial, 140 patients with high-risk type 2 diabetes were randomized to high-dose eplerenone (100–200 mg daily) or placebo as add-on to standard care for 26 weeks. Left ventricular systolic and diastolic function, indexed left ventricular mass (LVMi), and global longitudinal strain (GLS) were assessed using echocardiography at baseline and after 26 weeks of treatment.

Results
Of the included patients, 138 (99%) had an echocardiography performed at least once. Baseline early diastolic in-flow velocity (E-wave) indexed by mitral annulus velocity (e’) was mean (SD) 11.1 (0.5), with 31% of patients reaching above 12. No effect of treatment on diastolic function was observed measured by E/e’ (0.0, 95%CI [-1.2 to 1.2], P = 0.992) or E/A (-0.1, 95%CI [-0.2 to 0.0], P = 0.191). Mean left ventricular ejection fraction (LVEF) at baseline was 59.0% (8.0). No improvement in systolic function was observed when comparing groups after 26 weeks (LVEF: 0.9, 95%CI [-1.1 to 2.8], P = 0.382; GLS: -0.4%, 95%CI [-1.5 to 0.6], P = 0.422), nor in LVMi (-3.8 g/m2 95%CI [-10.2 to 2.7], P = 0.246).

Conclusion
In the present echo sub-study, no change in left ventricular function was observed following high-dose MRA therapy in patients with type 2 diabetes when evaluated by conventional echocardiography.

Trial registration
Date of registration 25/08/2015 (EudraCT number: 2015–002,519-14).
Finite element analysis of a novel anatomical locking plate for scapular neck fracture
Authors: Xiang Feifan , Xiao Yukun , Wei Daiqing , Tan Xiaoqi , He Siyuan , Luo Liang , Yang Yunkang 
Published: March 2023

Abstract
Objectives
Reconstruction plates (RPs) are commonly used in scapular neck fractures (SNFs): however, RPs have many defects. In this study, we evaluated a newly designed scapular neck anatomical locking compression plate (SNALCP).

Methods
An SNF finite element model (Miller-type IIB) was constructed. Plates were subsequently implanted into the scapula and fixed with screws that were grouped according to the plate used: SNALCP (A) and RP (B). Finally, loads were applied to record and analyze performance.

Results
Under lateral, anteroposterior, and vertical compression loads, the maximum von Mises stresses on the scapula and implants of group A were smaller than those of group B. There were some differences in stress distribution between the two groups.

Conclusions
SNALCP can effectively reduce the stress of the scapula and implant, making stress distribution more uniform and continuous, and has mechanical conduction advantages. Compared to RP, it provides improved stability and more reliable fixation.
Maturation state of colonization sites promotes symbiotic resiliency in the Euprymna scolopes-Vibrio fischeri partnership
Authors: Essock-Burns Tara , Lawhorn Susannah , Wu Leo , McClosky Sawyer , Moriano-Gutierrez Silvia , Ruby Edward G. , McFall-Ngai Margaret J. 
Published: March 2023

Abstract
Background
Many animals and plants acquire their coevolved symbiotic partners shortly post-embryonic development. Thus, during embryogenesis, cellular features must be developed that will promote both symbiont colonization of the appropriate tissues, as well as persistence at those sites. While variation in the degree of maturation occurs in newborn tissues, little is unknown about how this variation influences the establishment and persistence of host-microbe associations.

Results
The binary symbiosis model, the squid-vibrio (Euprymna scolopes-Vibrio fischeri) system, offers a way to study how an environmental gram-negative bacterium establishes a beneficial, persistent, extracellular colonization of an animal host. Here, we show that bacterial symbionts occupy six different colonization sites in the light-emitting organ of the host that have both distinct morphologies and responses to antibiotic treatment. Vibrio fischeri was most resilient to antibiotic disturbance when contained within the smallest and least mature colonization sites. We show that this variability in crypt development at the time of hatching allows the immature sites to act as a symbiont reservoir that has the potential to reseed the more mature sites in the host organ when they have been cleared by antibiotic treatment. This strategy may produce an ecologically significant resiliency to the association.

Conclusions
The data presented here provide evidence that the evolution of the squid-vibrio association has been selected for a nascent organ with a range of host tissue maturity at the onset of symbiosis. The resulting variation in physical and chemical environments results in a spectrum of host-symbiont interactions, notably, variation in susceptibility to environmental disturbance. This “insurance policy” provides resiliency to the symbiosis during the critical period of its early development. While differences in tissue maturity at birth have been documented in other animals, such as along the infant gut tract of mammals, the impact of this variation on host-microbiome interactions has not been studied. Because a wide variety of symbiosis characters are highly conserved over animal evolution, studies of the squid-vibrio association have the promise of providing insights into basic strategies that ensure successful bacterial passage between hosts in horizontally transmitted symbioses.
Developing a Data and Analytics Platform to Enable a Breast Cancer Learning Health System at a Regional Cancer Center
Authors: Petch Jeremy , Kempainnen Joel , Pettengell Christopher , Aviv Steven , Butler Bill , Pond Greg , Saha Ashirbani , Bogach Jessica , Allard-Coutu Alexandria , Sztur Peter , Ranisau Jonathan , Levine Mark 
Published: March 2023

PURPOSE This study documents the creation of automated, longitudinal, and prospective data and analytics platform for breast cancer at a regional cancer center. This platform combines principles of data warehousing with natural language processing (NLP) to provide the integrated, timely, meaningful, high-quality, and actionable data required to establish a learning health system. METHODS Data from six hospital information systems and one external data source were integrated on a nightly basis by automated extract/transform/load jobs. Free-text clinical documentation was processed using a commercial NLP engine. RESULTS The platform contains 141 data elements of 7,019 patients with newly diagnosed breast cancer who received care at our regional cancer center from January 1, 2014, to June 3, 2022. Daily updating of the database takes an average of 56 minutes. Evaluation of the tuning of NLP jobs found overall high performance, with an F1 of 1.0 for 19 variables, with a further 16 variables with an F1 of > 0.95. CONCLUSION This study describes how data warehousing combined with NLP can be used to create a prospective data and analytics platform to enable a learning health system. Although upfront time investment required to create the platform was considerable, now that it has been developed, daily data processing is completed automatically in less than an hour.
Ethics & Governance of Research: Focus on Research Ethics Committees globally, disparities across regions and the understanding of the structures and systems in place for publicly available information
Authors: Tzermpinou Anthi 
Published: March 2023

This publication presents the findings of the Research submitted for the degree of MRes in Bioeconomy Biotechnology & Law that was conducted in May 2022 at the International Hellenic university in Thessaloniki, Greece. The original research purpose was to gather information on the coherence or disparities that exist in the current environment within the established ethics committees on the country or regional level. Several elements were taken into consideration on their structural systems in place in terms of: governance, standard operating procedures, trainings, and reporting systems (internal but as well as external)] but the outcome of this research serves also as a baseline as “the outcome of a person’s understanding (author) on the current environment based on publicly available information” to reach to the desired result which is to establish a clear understanding on the current procedures of the ethics committees from a person without extensive knowledge or constant exposure to their inner environment. Therefore, there are two elements that were simultaneously under research.
This article presents the results based on the findings of this research but as well the barriers (limitations and restraints) contributing to their understanding. The author provides closing recommendations on the organizational level but as well on a fundamental level to provide alignment but as well as a request for clarity on the existing publicly available information in a manner that is easy to understand to the simple reader which contributes to transparency on research.
StableFees: A Predictable Fee Market for Cryptocurrencies
Authors: Basu Soumya , Easley David , O’Hara Maureen , Sirer Emin Gün 
Published: March 2023

Blockchain-based cryptocurrencies must solve the problem of assigning priorities to competing transactions. The most widely used mechanism involves each transaction offering a fee to be paid once the transaction is processed, but this discriminatory price mechanism fails to yield stable equilibria with predictable prices. We propose an alternate fee setting mechanism, StableFees, that is based on uniform price auctions. We prove that our proposed protocol is free from manipulation by users and miners as the number of users and miners increases and show empirically that gains from manipulation are small in practice. We show that StableFees reduces the fees paid by users and reduces the variance of fee income to miners. Data from December 2017 show that, if implemented, StableFees could have saved Bitcoin users $272,528,000 USD in transaction fees while reducing the variance of miner’s fee income, on average, by a factor of 7.4. We argue that our fee protocol also has important social welfare and environmental benefits. This paper was accepted by Agostino Capponi, Special Section of Management Science: Blockchains and Crypto Economics. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4735 .
Effectiveness of Collaboration in VET: Measuring Skills for Solving Complex Vocational Problems With a Multidimensional Authentic Technology-Based Assessment
Authors: Paeßens Jessica , Ma Beifang , Winther Esther 
Published: March 2023

Context:Collaboration and digitization in work and production process have been of scientific interest in the research field of vocational education and training for decades. So far, there is a lack of empirical evidence on the extent to which the performance of collaborative problem-solving can outperform individual problem-solving. An appropriate instrument for measuring collaborative performance appropriately has been lacking to this point: It is challenging to (1) collect data on interaction in collaboration in a standardized way and (2) to assign the individual performances to the group performance. In a web-based office simulation, this study examined the two-dimensional construct of collaborative problem-solving ability, which consists of cognitive and social components, and explored the effectiveness of collaboration.
Methods:The test settings are systematically varied between individual and collaborative problem-solving in a domain-typical problem scenario in the economic domain. A theory-driven two-dimensional authentic instrument with a complex commercial problem in a web-based office simulation was applied to measure the performance in these two test settings. Multi-Group Confirmatory Factor Analysis was conducted to test for measurement invariance across test settings, the two-dimensional RASCH-Model incorporating between-item multidimensionality with correlated dimensions was used for ability estimation. ANOVA test was conducted to determine if there is a statistically significant difference with respect to the ability between the individual and collaborative test settings.
Findings:The two-dimensional construct of collaborative problem-solving ability with correlated dimensions showed better fit than the unidimensional construct. The scalar measurement invariance was established after excluding three items. ANOVA tests confirmed that the collaborative setting enhances the problem-solving ability of learners significantly in both the cognitive component and social component, and the ability in cognitive component was more fostered.
Conclusion:The findings suggested the validation of this multidimensional authentic instrument to measure the performance in a collaborative work environment in economic domains. The results showed the effectiveness of collaboration with a computer-based agent. In the practice of vocational training and education, teachers can use this instrument for the evaluation of the effectiveness of collaboration.
El corpus ESLORA de español oral: un recurso para la investigación en ELE
Authors: Vázquez Rozas Victoria , Blanco Marta 
Published: March 2023

En esta contribución se presenta el corpus ESLORA (https://eslora.usc.es/) y se describen, mediante ejemplos concretos, algunas de sus posibilidades de explotación como recurso para la investigación en español lengua extranjera (ELE). En primer lugar (§ 1.1), se contextualiza el proyecto y se resumen sus objetivos generales; en el § 1.2 se presentan las características de composición y diseño del corpus, con especial atención a aquellos aspectos directamente relacionados con sus posibilidades de explotación para la investigación lingüística; y en el § 1.3 se exponen las opciones que ofrece la interfaz de consulta para recuperar la información. La segunda parte incluye la descripción de varios casos prácticos de utilización del corpus para el estudio de fenómenos relevantes en la enseñanza y aprendizaje de ELE. El § 2.1 está dedicado a dos mecanismos derivativos, los afijos -ito/a/os/as y super-; el § 2.2 trata aspectos de la combinatoria sintáctica de los verbos ser y estar; el § 2.3 se centra en el uso y valores de las partículas discursivas; por último, en el § 2.4 se recoge un ejemplo de trabajo colaborativo entre docentes e investigadores de acuerdo con la metodología de investigación-acción, que atiende a la expresión del futuro en español.
Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis
Authors: Xiong Yu , Guo Xiumei , Huang Xinyue , Kang Xiaodong , Zhou Jianfeng , Chen Chunhui , Pan Zhigang , Wang Linxing , Goldbrunner Roland , Stavrinou Lampis , Stavrinou Pantelis , Lin Shu , Chen Yuping , Hu Weipeng , Zheng Feng 
Published: March 2023

Background
Although some studies have shown that tranexamic acid is beneficial to patients with intracranial haemorrhage, the efficacy and safety of tranexamic acid for intracranial haemorrhage remain controversial.

Method
The PubMed, EMBASE, and Cochrane Library databases were systematically searched. The review followed PRISMA guidelines. Data were analyzed using the random-effects model.

Results
Twenty-five randomized controlled trials were included. Tranexamic acid significantly inhibited hematoma growth in intracranial hemorrhage (ICH) and traumatic brain injury (TBI) patients. (ICH: mean difference -1.76, 95%CI -2.78 to -0.79, I2 = 0%, P < .001; TBI: MD -4.82, 95%CI -8.06 to -1.58, I2 = 0%, P = .004). For subarachnoid hemorrhage (SAH) patients, it significantly decreased the risk of hydrocephalus (OR 1.23, 95%CI 1.01 to 1.50, I2 = 0%, P = .04) and rebleeding (OR, 0.52, 95%CI 0.35 to 0.79, I2 = 56% P = .002). There was no significance in modified Rankin Scale, Glasgow Outcome Scale 3–5, mortality, deep vein thrombosis, pulmonary embolism, or ischemic stroke/transient ischemic.

Conclusion
Tranexamic acid can significantly reduce the risk of intracranial haemorrhage growth in patients with ICH and TBI. Tranexamic acid can reduce the incidence of complications (hydrocephalus, rebleeding) in patients with SAH, which can indirectly improve the quality of life of patients with intracranial haemorrhage.
Endomarketing as a tool for excellence: A case study of a hotel in João Pessoa – PB
Authors: Brambilla Adriana , Santos Emily Alana Lourenço dos 
Published: March 2023

Endomarketing is a valuable management tool in many enterprises, including the hotel industry. This article presents the results of a case study whose goal was to analyze Endomarketing in a hotel located in João Pessoa-PB. The research design was exploratory and descriptive, with quantitative and qualitative approaches, through the application of a questionnaire to the employees in the reception, food and beverage, governance, and maintenance sectors who have direct contact with the services provided to the final consumer, and an interview with the general manager responsible for the equipment studied, to find out his perception of Endomarketing. To protect the respondents’ confidentiality, the enterprise studied was given the fictitious name of Maré Hotels. This accommodation establishment was chosen because it carries out marketing and is commercially recognized work in area of hotel management. The results show that even though the company is stable and well-known, some aspects can be improved; it was also understood the employees are satisfied in terms of corporate communication and professional recognition.
City Alta Walking Trail: An analysis in light of the cultural heritage of the city of João Pessoa/PB
Authors: Guilherme Francinete da Silva , Melo Alessandra Souza Queiroz 
Published: March 2023

The City Alta Walking Trail was first launched in 2008, to commemorate the first year of listed status of the historic center of the city of João Pessoa/Paraíba. The walking trail took in key points marking the history of the city, but over time, it fell into disuse. In view of the importance of the walking trail for preserving the material and immaterial cultural heritage of João Pessoa/PB, this work describes the historical heritage that can be seen along the trail, and assesses the feasibility of reestablishing the trail project. This work was developed based on documentary and bibliographic research. It is qualitative, and exploratory in character, and involved field research. Analyzing the landmarks along the trail, it was seen that these points were drastically decreased in number. But the material heritage of the city is of historical importance, with the potential to develop tourism in this segment. In order to reestablish the walking trail, improvements must be made to the attractions, understanding the benefits for the city and the population.
Development of AHP-embedded Deng’s hybrid MCDM model in micro-EDM using carbon-coated electrode
Authors: Pham Van Dong , Huu Phan Nguyen , Minh Nguyen Duc 
Published: March 2023

Abstract
The use of thin film-coated micro-tool electrode introduced a new technical solution to bring the best technical–economic efficiency in the field of non-conventional machining processes. Multi-objective optimization of process parameters in micro-electrical discharge machining (EDM) is very limited with the help of thin film-coated micro-tool, which brought benefits for the industry. In this research work, the technological parameters such as voltage (V), spindle rotation, and capacitance (C) in micro-EDM using carbon-coated electrode were optimized, and Z-coordinate depth of cut and tool wear rate were selected as response variables. Taguchi is combined with Deng’s method to solve this multi-objective decision problem. The results showed that Taguchi–Deng’s method is the right solution for multi-target decision in micro-EDM using the coated electrode. C is the strongest influence on optimal efficiency, and it is the smallest with V. The machining quality under optimal conditions is improved.