bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simcan2Cloud: a discrete-event-based simulator for modelling and simulating cloud computing infrastructures
Authors: Cañizares Pablo C. , Núñez Alberto , Bernal Adrián , Cambronero M. Emilia , Barker Adam 
Published: September 2023

AbstractCloud computing is an evolving paradigm whose adoption has been increasing over the last few years. This fact has led to the growth of the cloud computing market, together with fierce competition for the leading market share, with an increase in the number of cloud service providers. Novel techniques are continuously being proposed to increase the cloud service provider’s profitability. However, only those techniques that are proven not to hinder the service agreements are considered for production clouds. Analysing the expected behaviour and performance of the cloud infrastructure is challenging, as the repeatability and reproducibility of experiments on these systems are made difficult by the large number of users concurrently accessing the infrastructure. To this, must be added the complications of using different provisioning policies, managing several workloads, and applying different resource configurations. Therefore, in order to alleviate these issues, we present Simcan2Cloud, a discrete-event-based simulator for modelling and simulating cloud computing environments. Simcan2Cloud focuses on modelling and simulating the behaviour of the cloud provider with a high level of detail, where both the cloud infrastructure and the interactions of the users with the cloud are integrated in the simulated scenarios. For this purpose, Simcan2Cloud supports different resource allocation policies, service level agreements (SLAs), and an intuitive and complete API for including new management policies. Finally, a thorough experimental study to measure the suitability and applicability of Simcan2Cloud, using both real-world traces and synthetic workloads, is presented.
Role of dopamine in the pathophysiology of Parkinson’s disease
Authors: Zhou Zhi Dong , Yi Ling Xiao , Wang Dennis Qing , Lim Tit Meng , Tan Eng King 
Published: September 2023

AbstractA pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmitter of dopaminergic neurons. Accumulating evidence suggests that DA interacts with environmental and genetic factors to contribute to PD pathophysiology. Disturbances of DA synthesis, storage, transportation and metabolism have been shown to promote neurodegeneration of dopaminergic neurons in various PD models. DA is unstable and can undergo oxidation and metabolism to produce multiple reactive and toxic by-products, including reactive oxygen species, DA quinones, and 3,4-dihydroxyphenylacetaldehyde. Here we summarize and highlight recent discoveries on DA-linked pathophysiologic pathways, and discuss the potential protective and therapeutic strategies to mitigate the complications associated with DA.
“Good luck, social distance”: rapid decarceration and community care for serious mental illness and substance use disorder during the COVID-19 pandemic
Authors: James Jennifer E. , Dauria Emily F. , Desai Riya , Bell Adelaide , Izenberg Jacob M. 
Published: September 2023

AbstractThe COVID-19 pandemic inspired calls for rapid decarceration of prisons and jails to slow the spread of disease in a high-risk congregate setting. Due to the rarity of intentionally-decarcerative policies, little is known about the effects of rapid decarceration on individuals with serious mental illness (SMI) substance use disorder (SUD), a population who receive many services via the criminal legal system (CLS). We conducted interviews with 13 key informants involved in CLS in San Francisco, CA to better understand the implication of the decarcerative policies put into practice in early 2020. Participants described a tension between the desire to have fewer people incarcerated and the challenges of accessing services and support – especially during the lockdown period of the pandemic – outside of the CLS given the number of services that are only accessible to those who have been arrested, incarcerated, or sentenced. These findings emphasize the need for investing in community social services rather than further expanding the CLS to achieve the goal of supporting individuals with SMI and SUD shrinking the US system of mass incarceration.
A meta-analysis of systematic reviews and meta-analyses to evaluate the psychological consequences of COVID-19
Authors: Sokouti Massoud , Shafiee-Kandjani Ali Reza , Sokouti Mohsen , Sokouti Babak 
Published: September 2023

Abstract
Background
Several meta-analysis studies have been reported in the literature on the incidence of psychopathological conditions resulting from the COVID-19 pandemic. This investigation aims to compile and analyze the findings of previously published meta-analysis research, as shown by the present meta-analysis of previous meta-analysis studies.

Methods
The PubMed and Scopus databases were searched from 1 January 2019 to 30 May 2022. The procedure was carried out according to the PRISMA flow chart and the qualities of the identified studies were analyzed using AMSTAR 2. Heterogeneities and risk of bias were assessed using the Meta-MUMS tool. The corresponding results, forest and funnel plots of the psychological consequences of COVID-19 were synthesized.

Results
Eleven meta-analysis studies were included. Random-effects meta-analysis of anxiety and depression showed (ER = 0.318 p-value < 0.001, ER = 0.295 p-value < 0.001) high heterogeneities (I2 = 99.70%, I2 = 99.75) between studies. Random-effects meta-analyses of sleep difficulties and insomnia were shown (ER = 0.347 p-value < 0.001, ER = 0.265, p-value < 0.001) along with heterogeneities (I2 = 99.89, I2 = 99.64). According to the random meta-analysis of post-traumatic stress syndrome (PTSS) and post-traumatic stress disorder (PTSD) (ER = 0.246, p-value = 0.001, ER = 0.223 p-value < 0.001) with heterogeneities (I2 = 99.75, I2 = 99.17). Random-effects meta-analyses of somatic and fear symptoms have been shown (ER = 0.16 p-value < 0.001, ER = 0.41, p-value = 0.089) with high heterogeneities (I2 = 99.62, I2 = 98.63). Random-effects meta-analysis of obsessive–compulsive symptoms and distress (ER = 0.297 p-value = 0.103; ER = 0.428, p-value = 0.013) with high heterogeneity, as I2 = 99.38%. Subgroup analysis of all symptoms and Egger's tests for detecting publication bias were also assessed.

Conclusion
The data from the current meta-analysis showed different psychological disorders of COVID-19 during the pandemic. Clinicians should be aware of the prevalence with which COVID-19-infected patients experience emotional distress, anxiety, fatigue, and PTSD. About half of the included systematic reviews (SRs)/meta-analyses (MAs) suffered from poorer methodological quality and increased risk of bias, reducing confidence in the findings. There must be more SRs/MAs and high-quality clinical trials conducted to confirm these findings.
Seed nano-priming using silica nanoparticles: effects in seed germination and physiological properties of Stevia Rebaudiana Bertoni
Authors: Hasanaklou Nasibeh Tavakoli , Mohagheghi Vahid , Hasanaklou Hourieh Tavakoli , Ma’mani Leila , Malekmohammadi Marjan , Moradi Foad , Dalvand Yadollah 
Published: September 2023

Abstract
Background
This study aimed to assess the effects of different concentrations of silicon (Si) nutrient sources, including bulk silicon dioxide (bSiO2) and two types of silica nanoparticles, nSiO2 (I) and nSiO2 (II) at different concentrations of 1, 5, 10, 25, 50, and 100 ppm in the germination process of stevia. The priming experiment was conducted using a completely randomized design with three replicates to ensure the reliability of the results.

Results
All stevia seedlings subjected to nano-priming significantly improved the germination parameters. The germination percentage increased by 106%, reaching 68% in nano-primed seedlings. Similarly, the germination rate showed a remarkable increase of 128.12% at 7.3 day−1. Additionally, the root, shoot, and seedling dry weight increased by 283%, 168.9%, and 220% and determined 0.092, 0.078, and 0.17 g plant−1, respectively, compared to the control. Furthermore, seed priming with nSiO2 (I) at a concentration of 10 ppm resulted in an increased catalase (CAT) activity (36.15 Umg−1 protein) and peroxidase (POX) activity (approximately 0.057 U.mg−1 protein). Also, the highest sucrose amount was observed in the root (equal to 160.4 μg g−1 DW) and shoot (equal to 247 μg g−1 DW) of seedlings primed with 10 ppm of nSiO2 (I). However, it should be noted that nano-priming at the highest concentration led to oxidative damage indicated by an increase in H2O2 concentration. Conversely, bSiO2 demonstrated a lesser effect on improving germination, seedling growth, antioxidant activities, and biochemical attributes compared to nSiO2 (I), and nSiO2 (II).

Conclusions
This study established that seed priming with nSiO2 (I) at a concentration of 10 ppm was the most effective in enhancing germination percentage and rate, root/shoot/dry weight, biochemical attributes, and enzyme activities (such as α-amylase, CAT, and POX). The results suggested that seed priming with nSiO2 (I) at the optimal concentration could improve the seed germination by enhancing the antioxidant system, starch metabolism, and ultimately protecting plants from oxidative damage.

Graphical Abstract
Prediction of p53 mutation status in rectal cancer patients based on magnetic resonance imaging-based nomogram: a study of machine learning
Authors: Zhong Xia , Peng Jiaxuan , Shu Zhenyu , Song Qiaowei , Li Dongxue 
Published: September 2023

Abstract
Background
The current study aimed to construct and validate a magnetic resonance imaging (MRI)-based radiomics nomogram to predict tumor protein p53 gene status in rectal cancer patients using machine learning.

Methods
Clinical and imaging data from 300 rectal cancer patients who underwent radical resections were included in this study, and a total of 166 patients with p53 mutations according to pathology reports were included in these patients. These patients were allocated to the training (n = 210) or validation (n = 90) cohorts (7:3 ratio) according to the examination time. Using the training data set, the radiomic features of primary tumor lesions from T2-weighted images (T2WI) of each patient were analyzed by dimensionality reduction. Multivariate logistic regression was used to screen predictive features, which were combined with a radiomics model to construct a nomogram to predict p53 gene status. The accuracy and reliability of the nomograms were assessed in both training and validation data sets using receiver operating characteristic (ROC) curves.

Results
Using the radiomics model with the training and validation cohorts, the diagnostic efficacies were 0.828 and 0.795, the sensitivities were 0.825 and 0.891, and the specificities were 0.722 and 0.659, respectively. Using the nomogram with the training and validation data sets, the diagnostic efficacies were 0.86 and 0.847, the sensitivities were 0.758 and 0.869, and the specificities were 0.833 and 0.75, respectively.

Conclusions
The radiomics nomogram based on machine learning was able to predict p53 gene status and facilitate preoperative molecular-based pathological diagnoses.
Intrahepatic cholangiocarcinoma with extensive intraductal extension of high-grade biliary intraepithelial neoplasia: a case report
Authors: Kubota Haruna , Hashimoto Yasushi , Toyota Kazuhiro , Yano Raita , Kobayashi Hironori , Yokoyama Yujiro , Sakashita Yoshihiro , Taniyama Kiyomi , Miyamoto Katsunari , Murakami Yoshiaki 
Published: September 2023

Abstract
Background
Intrahepatic cholangiocarcinoma (ICC) is frequently associated with precursor lesions, and biliary intraepithelial neoplasia (BilIN) may play a significant role in the development of ICC. However, the exact sequence and progression of these lesions remain to be elucidated. We report a rare case of ICC that exhibited extensive longitudinal intraductal extension of high-grade BilIN in the posterior bile ducts and involved the hepatic hilum and the peripheral hepatic parenchyma.

Case presentation
A 70-year-old female presented with anorexia. Computed tomography (CT) revealed a 15 mm enhancing intrahepatic tumor extending to the right intrahepatic secondary confluence. This was associated with a 7 mm diameter cystic dilatation of the segment 6 bile duct (B6). Endoscopic retrograde cholangiopancreatography (ERCP) revealed stenosis at the bifurcation of the posterior bile duct branch. Bile cytology confirmed the diagnosis of adenocarcinoma cells. Therefore, the patient was diagnosed with an ICC involving the right glissonean pedicle and underwent a right hepatectomy and lymph node dissection. Histologic examination revealed the tumor consisted of moderately differentiated adenocarcinoma. In connection with this lesion, diffuse intraductal atypical epithelial cells, which were diagnosed as high-grade BilIN, was observed not only in the dilated B6 but in the entire posterior bile ducts, which measured approximately 120 mm in diameter. Furthermore, two distinct foci of adenocarcinomas were identified in the peripheral hepatic parenchyma. A lymph node metastasis was also present. The pathological diagnosis was ICC pT4N1M0 stage IVA. The patient underwent adjuvant chemotherapy and has shown no recurrence 5 years after surgery. Imaging modalities were unable to accurately assess the extent of the intraductal neoplastic lesions due to their low papillary or sessile intraductal tubular growth. No risk factors for BilIN development, which has the potential to predispose to cholangiocarcinoma, were identified in the present case.

Conclusions
We present a case of ICC involving the right hepatic hilum, accompanied by extensive longitudinal extensions of high-grade BilIN and multifocal microscopic invasions in peripheral hepatic parenchyma. Notably, the intraductal lesions involved the entire posterior intrahepatic bile ducts. The presence of biliary neoplasia with extensive intraductal extension, in conjunction with ICC, should be considered as a variant of BilIN.
Nanoarchitectured conjugates targeting angiogenesis: investigating heparin-taurocholate acid conjugates (LHT7) as an advanced anti-angiogenic therapy for brain tumor treatment
Authors: Kim Hyung Shik , Seol Jae Hak , Hwang Hae Hyun , Lee Dong Yun 
Published: September 2023

Abstract

Background
Glioblastoma is a highly malignant brain tumor associated with poor prognosis. Conventional therapeutic approaches have limitations due to their toxic effects on normal tissue and the development of tumor cell resistance. This study aimed to explore alternative mechanisms for glioblastoma treatment by targeting angiogenesis.

Methods
The study investigated the anti-angiogenic properties of heparin in glioblastoma treatment. To overcome the limitations of heparin, a heparin-taurocholate conjugate (LHT7) was synthesized by conjugating heparin to taurocholic acid. The study utilized the U87MG human glioblastoma cell line and human umbilical vein endothelial cells (HUVEC) as experimental models. Cell viability assays and sprouting assays were performed to assess the effects of LHT7. Additionally, phosphorylation of angiogenesis-related proteins, such as phospho-ERK and phospho-VEGFR2, was measured. The anti-angiogenic effects of LHT7 were further evaluated using a glioblastoma orthotopic mouse model.

Results
Treatment with LHT7 resulted in a dose-dependent reduction in cell viability in U87MG human glioblastoma cells. The sprouting of HUVEC cells was significantly decreased upon LHT7 treatment. Furthermore, LHT7 treatment led to a decrease in the phosphorylation of angiogenesis-related proteins, including phospho-ERK and phospho-VEGFR2. In the glioblastoma orthotopic mouse model, LHT7 exhibited anti-angiogenic effects, supporting its potential as a therapeutic agent.

Conclusions
The conjugation of heparin and taurocholic acid to create LHT7 offers several advantages over conventional therapeutic approaches for glioblastoma. LHT7 demonstrated anti-angiogenic properties, as evidenced by the reduction in cell viability and inhibition of endothelial cell sprouting. Moreover, LHT7 modulated the phosphorylation of angiogenesis-related proteins. These findings suggest that LHT7 holds promise as a medication for glioblastoma treatment, offering potential implications for improving patient outcomes.

Graphical Abstract
Evaluation of freshwater heavy metals accumulation effect on oxidative stress, Metallothionein biosynthesis and histopathology of Procambarus clarkii (Girard,1985) collected from three locations in the Delta region, Egypt
Authors: Mona Mahy M. , Younis Mai L. , Atlam Aalaa I. 
Published: September 2023

Abstract
Background
In this study, the effect of heavy metals accumulation influence was evaluated on adult crayfish Procambarus clarkii (Decapoda, Astacidea) collected from three different Governmental locations (Kafr El-Shaikh, El-Menofya, and El-Gharbiya) of the Egyptian Delta. The activity of super oxidase dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) of gills, hepatopancreas, and muscle tissue were measured. SDS Polyacrylamide gel electrophoresis (SDS-PAGE) and West blotting technique were performed to detect MT Protein expression.

Results
The results revealed that Kafr El-Shaikh reflected the highest Superoxide dismutase (SOD), Catalase, and Glutathione S-transferase (GST) activity levels (97.2 u/100 mg, 28.5 u/100 mg, and 8.3 nmol mg (-1) protein min (-1) respectively. Superior protein polymorphism % (30%) remarked collected Freshwater crayfish P. clarkii from Kafr El-Shaikh location. Varied protein polymorphism % was shown between collected crayfish from El-Menofya, and El-Gharbiya locations (5.5 and 6.2 respectively) Increasing Metallothioneins intensity (15.4%) for collected Freshwater crayfish Procambarus clarkii from Kafr El-Shaikh Location.

Conclusion
Heavy metal stress influences antioxidant status and also induces increasing Metallothioneins intensity, especially samples that were collected from the Kafr El-Shaikh area.
Effect of cognitive retraining treatment in mild to moderate depressive disorders
Authors: Gupta Aarzoo , Kumari Santha 
Published: September 2023

Abstract

Background
Cognitive retraining or remediation approaches dispense high levels of stimulation and new learning tasks, leading to an increased neural connections, which facilitate rapid recovery in patients with neurological as well as psychiatric conditions.

Objectives
The current study aimed to investigate the effect of cognitive retraining (CR) in depressive disorders. We assigned 40 patients with mild to moderate depression to two sample groups, with 20 participants each: CR alone and CR with medicine. A 6-week CR module was delivered, and participants’ scores on measures such as the Beck Depression Inventory-II, Metacognition Questionnaire 30, World Health Organization Quality of Life- Brief, and Global Assessment of Functioning were compared.

Results
Analysis using Stata/IC version 16 included descriptive statistics, paired and independent t-tests, analysis of covariance, and propensity score matching. Cohen's d was computed to determine the effect size. Within-group analysis revealed statistically significant differences in pre-post scores of the outcome measures (p < .05) and large effect size (d = 3.41; d = 3.60) in both groups. The difference in scores of outcome measures between the groups was not significant (p > .05) even when covariates were controlled, or nearest neighbor match analysis was carried out. CR is effective in alleviating symptoms and dysfunctional metacognitive beliefs in addition to enhancing functioning and quality of life.

Conclusions
CR-based interventions may be essential mental health services owing to growing research in psychotherapy via virtual modes such as tele- and video-conferencing. These interventions can substantiate both prevention and remedy.
Viscoelastic properties of small bowel mesentery at MR elastography in Crohn’s disease: a prospective cross-sectional exploratory study
Authors: van Schelt Anne-Sophie , Beek Kim Johanna , Wassenaar Nienke Petronella Maria , Schrauben Eric M. , Runge Jurgen H. , Gecse Krisztina Barbara , van der Bilt Jarmila D. W. , Neefjes-Borst E. Andra , Buskens Christianne Johanna , Nederveen Aart J. , Stoker Jaap 
Published: September 2023

Abstract
Background
Creeping fat is a pathological feature of small bowel Crohn’s disease (CD), with literature suggesting that bowel resection with extended mesenteric resection is related to less postoperative recurrences. Conventional imaging is unable to accurately quantify the disease involvement (i.e., fibrosis) of creeping fat. Quantification of disease involvement could be useful in decision-making for additional extended mesenteric resection. We investigated the feasibility of magnetic resonance elastography (MRE) of the mesentery and if MRE is capable to detect fibrotic disease involvement of mesentery in active CD.

Methods
Multifrequency MRE yielded spatial stiffness (shear wave speed, SWS, |G*|) and fluidity maps (φ). Viscoelastic properties of seven CD patients’ mesentery were compared to age- and sex-matched healthy volunteers (HV) (Mann–Whitney U-test). Within CD patients, the affected and “presumably” unaffected mesentery were compared (Wilcoxon-signed rank test). Repeatability was tested in 15 HVs (Bland–Altman analysis, coefficient of variation [CoV]). Spearman rank correlations were used to investigate the relation between microscopically scored amount of mesenteric fibrosis and viscoelastic parameters.

Results
SWS, |G*|, and φ of affected mesentery in CD were higher compared to HV (p = 0.017, p = 0.001, p = 0.017). Strong correlations were found between percentage of area of mesenteric fibrosis and SWS and |G*| (p < 0.010). No differences were found within CD between affected and presumably unaffected mesentery. Repeatability of SWS showed 95% limits of agreement of (-0.09, 0.13 m/s) and within-subject CoV of 5.3%.

Conclusion
MRE may have the potential to measure fibrotic disease involvement of the mesentery in CD, possibly guiding clinical decision-making with respect to extended mesenteric resection.

Trial registration
Dutch trial register, NL9105, registered 7 December 2020.

Relevance statement
MRE may have the potential to measure the amount of mesenteric fibrosis of the affected mesenteric fat in active Crohn’s disease, giving more insight into disease progression and could potentially play a role in clinical decision-making for extended mesenteric resection.

Key points
• MRE of the mesentery in patients with active CD is feasible.
• Fluidity and stiffness of the mesentery increase in active CD, while stiffness correlates with the histopathological amount of mesenteric fibrosis.
• MRE provides biomarkers to quantify mesenteric disease activity in active CD.

Graphical Abstract