bluuebunny/crossref_metadata_2025_split huggingface dataset:
PANoptosis-related prognostic signature predicts overall survival of cutaneous melanoma and provides insights into immune infiltration landscape
Authors: Wang Wei , Zhou Qingde , Lan Lan , Xu Xinchang 
Published: May 2023

AbstractCutaneous melanoma (CM) is a highly malignant tumor originating from melanocytes, and its metastasis and recurrence are the major causes of death in CM patients. PANoptosis is a newly defined inflammatory programmed cell death that crosstalk pyroptosis, apoptosis, and necroptosis. PANoptosis participates in the regulation of tumor progression, especially the expression of PANoptosis related genes (PARGs). Although pyroptosis, apoptosis, and necroptosis have received attention in CM, respectively, the link between them remains elusive. Therefore, this study aimed to investigate the potential regulatory role of PANoptosis and PARGs in CM and the relationship among PANoptosis, PARGs and tumor immunity. We identified 3 PARGs associated with prognosis in CM patients by The Cancer Genome Atlas. Risk model and nomogram were established. Enrichment analysis of differentially expressed genes indicated that CM was immune-related. Subsequent analyses indicated that prognosis-related PARGs were associated with immune scores and infiltration of immune cells in CM patients. In addition, immunotherapy and drug sensitivity results indicated an association between prognosis-related PARGs and drug resistance in CM patients. In conclusion, PARGs play a key role in the progression of tumors in CM patients. PARGs can be used not only for risk assessment and OS prediction in CM patients, but also reflect the immune landscape of CM patients, which can provide a novel reference for individualized tumor treatment.
Investigation of blood flow characteristics saturated by graphene/CuO hybrid nanoparticles under quadratic radiation using VIM: study for expanding/contracting channel
Authors: Kumar Mishra Nidhish , Adnan  , ur Rahman Khaleeq , M. Eldin Sayed , Z. Bani-Fwaz Mutasem 
Published: May 2023

AbstractThe importance of heat transfer in nanoliquids cannot avoided because it playing crucial role in the applied research fields. The potential area of applications included but restricted to applied thermal, biomedical, mechanical and chemical engineering. Therefore, it is the need of time to introduce new efficient way to enhance the heat transport rate in common fluids. The major aim of this research is to develop a new heat transport BHNF (Biohybrid Nanofluid Model) model in a channel having expanding/contracting walls up to Newtonian regimes of blood. The two sort of nanomaterials (Graphene + CuO) along with blood as base solvent are taken for the formation of working fluid. After that, the model analyzed via VIM (Variational Iteration Method) to examine the influence of involved physical parameters on the behavior of bionanofluids. The model results revealed that the bionanofluids velocity rises towards the lower and upper channel end when the expanding/contracting of the walls in the range of 0.1–1.6 (expanding case) and $$- \, 0.1$$

-

0.1

to $$1.6$$

1.6

(contraction case). The working fluid attained high velocity in the neighboring of center portion of the channel. By increasing the walls permeability ($${A}_{1}=\text{0.1,0.2,0.3,0.4}$$

A
1

=
0.1,0.2,0.3,0.4

), the fluid movement can be reduced and optimum decrement observed about $$\eta =0.0$$

η
=
0.0

. Further, inclusion of thermal radiation (Rd) and temperature coefficient ($${\theta }_{r}$$

θ
r

) observed good to enhance thermal mechanism in both hybrid and simple bionanofluids. The present ranges of Rd and $${\theta }_{r}$$

θ
r

considered from $$0.1$$

0.1

to $$0.9$$

0.9

and $$0.1$$

0.1

to $$1.4$$

1.4

, respectively. Thermal boundary layer reduced in the case of simple bionanoliquid keeping $${P}_{r}=21.0$$

P
r

=
21.0

.
Structural evolution of metatitanic acid and iron removal during hydrolysis of industrial TiOSO4 solution
Authors: Tian Congxue , Ma Guangqiang , Ge Hongwei 
Published: May 2023

AbstractThe ferrous ion content of metatitanic acid affected the whiteness, purity and applications of TiO2, controlled by the hydrolysis conditions and metatitanic acid structure. The structural evolution of metatitanic acid and ferrous ion removal was investigated by hydrolyzing the industrial TiOSO4 solution. The hydrolysis degree was conformed to Boltzmann model with good fitting. TiO2 content of metatitanic acid gradually increased as hydrolysis proceeding due to its stronger compact structure and weaker colloidal property, caused by the aggregation and adjustment of the precipitated particles. At lower TiOSO4 concentration, the crystal size increased significantly, lattice strain decreased, and average particle size constantly adjusted and reduced. The micropores and mesopores were mainly formed by aggregating and stacking of primary agglomerate particles, bonded and filled with sulfate and hydroxyl. The ferrous ion content decreased linearly with the increase of TiO2 content, and reducing moisture content of metatitanic acid was an effective way to reduce Fe content. This would save more water and energy consumption, help to improve the clean production level of TiO2.
Oxytocin normalizes the implicit processing of fearful faces in psychopathy: a randomized crossover study using fMRI
Authors: Tully John , Sethi Arjun , Griem Julia , Paloyelis Yannis , Craig Michael C. , Williams Steven C. R. , Murphy Declan , Blair Robert James , Blackwood Nigel 
Published: May 2023

AbstractAdults with antisocial personality disorder with (ASPD + P) and without (ASPD – P) psychopathy commit the majority of violent crimes. Empathic processing abnormalities are particularly prominent in psychopathy, but effective pharmacological interventions have yet to be identified. Oxytocin modulates neural responses to fearful expressions in healthy populations. The current study investigates its effects in violent antisocial men. In a placebo-controlled, randomized crossover design, 34 violent offenders (19 ASPD + P; 15 ASPD – P) and 24 healthy non-offenders received 40 IU intranasal oxytocin or placebo and then completed an fMRI morphed faces task examining the implicit processing of fearful facial expressions. Increasing intensity of fearful facial expressions failed to appropriately modulate activity in the bilateral mid-cingulate cortex in violent offenders with ASPD + P, compared with those with ASPD – P. Oxytocin abolished these group differences. This represents evidence of neurochemical modulation of the empathic processing of others’ distress in psychopathy.
Kinetic simulations of solar wind plasma irregularities crossing the Hermean magnetopause
Authors: Voitcu G. , Echim M. , Teodorescu E. , Munteanu C. 
Published: May 2023

Context. The physical mechanisms that favor the access of solar wind plasma into the magnetosphere have not been entirely elucidated to date. Studying the transport of finite-sized magnetosheath plasma irregularities across the magnetopause is fundamentally important for characterizing the Hermean environment (of Mercury) as well as for other planetary magnetic and plasma environments.
Aims. We investigate the kinetic effects and their role on the penetration and transport of localized solar wind or magnetosheath plasma irregularities within the Hermean magnetosphere under the northward orientation of the interplanetary magnetic field.
Methods. We used three-dimensional (3D) particle-in-cell (PIC) simulations adapted to the interaction between plasma elements (irregularities or jets) of a finite spatial extent and the typical magnetic field of Mercury’s magnetosphere.
Results. Our simulations reveal the transport of solar wind plasma across the Hermean magnetopause and entry inside the magnetosphere. The 3D plasma elements are braked and deflected in the equatorial plane. The entry process is controlled by the magnetic field gradient at the magnetopause. For reduced jumps of the magnetic field (i.e., for larger values of the interplanetary magnetic field), the magnetospheric penetration is enhanced. The equatorial dynamics of the plasma element is characterized by a dawn-dusk asymmetry generated by first-order guiding center drift effects. More plasma penetrates into the dusk flank and advances deeper inside the magnetosphere than in the dawn flank.
Conclusions. The simulated solar wind or magnetosheath plasma jets can cross the Hermean magnetopause and enter into the magnetosphere, as described by the impulsive penetration mechanism.
MRSA in bulk tank milk of dairy herds in Germany – changes
over time
Authors: Tenhagen Bernd-Alois , Alt Katja , Grobbel Mirjam , Maurischat Sven 
Published: May 2023

Abstract
Objective Methicillin-resistant Staphylococcus aureus (MRSA) have
repeatedly been isolated from dairy herds. It was the purpose of this study to
compare the results of 3 subsequent national scale cross-sectional
investigations in dairy herds in Germany on the prevalence of MRSA in bulk tank
milk and the characteristics of the isolates.
Material and Methods The investigations were carried out in 2010, 2014 and
2019, respectively. MRSA were isolated from 25 ml of bulk tank milk
using a double selective enrichment protocol. Samples were distributed across
the country according to the regional dairy cattle population.
Results The prevalence of MRSA in bulk tank milk samples was lower in 2010
than in 2014 and tended to decrease until 2019. Prevalence was higher in samples
from conventional than from organic herds and increased with herd size. Most
isolates (75/78) were assigned to the clonal complex 398 and the
spa-types t011 and t034. Resistance of the isolates to other
antimicrobials than beta-lactams decreased over time.
Conclusions MRSA remain present in the German dairy population and are
found more frequently in larger vs. smaller herds and in conventional vs.
organic herds.
Clinical relevance MRSA should be considered in biosecurity protocols and
with respect to occupational health of farm staff. Presence of MRSA in raw milk
supports the recommendation not to drink unpasteurized raw milk.
Multizentrisches B-Zell-Lymphom bei einem 8 Wochen alten
Kalb
Authors: Frischkorn Marie , Fortelny Michael , Ciurkiewicz Malgorzata , Krüger Johannes , Jahn-Falk Doris 
Published: May 2023

ZusammenfassungDieser Fallbericht beschreibt den Krankheitsverlauf der sporadischen
Kälberleukose bei einem 8 Wochen alten männlichen Kreuzungskalb
der Rasse Red Holstein×Fleckvieh. Das Kalb wurde initial wegen einer
Bronchopneumonie vorgestellt. Dabei fiel eine für Kälbergrippe
untypische symmetrische hochgradige Vergrößerung der subkutanen
Lymphknoten auf. In Verbindung mit dem massenhaften Vorliegen von Blasten im
peripheren Blut und dem sonografischen Befund der Lymphknoten wurde die
Verdachtsdiagnose sporadische Kälberleukose gestellt. Drei Wochen nach
der Erstvorstellung verstarb das Kalb plötzlich. Die Sektion ergab eine
hochgradige Vergrößerung aller Lymphknoten und eine hochgradige
Infiltration nahezu aller Organe und Gewebe mit einer monomorphen
Rundzellpopulation. Dieser Zelltyp wurde auch in einem Knochenmarkausstrich
zytologisch nachgewiesen. Die immunhistochemische Untersuchung mit den Markern
Pax5 und CD 20 für B-Zellen verlief mit positivem Ergebnis. Die
virologische Untersuchung auf bovine Leukoseviren (BLV) war negativ.Zusammen mit der Diagnose eines multizentrischen B-Zell-Lymphoms sprachen die
Untersuchungsergebnisse für das Vorliegen einer sporadischen
Kälberleukose.
Recommendations for the Pharmacological Treatment of Osteoporosis
– Update 2023 of the German Osteoporosis Guideline
Authors: Schmidmaier Ralf , Hadji Peyman , Kern Peter , Drey Michael , Jakob Franz , Thomasius Friederike 
Published: May 2023

Abstract
Aim The German osteoporosis guideline was updated on the basis of a
systematic literature review and through a structured consensus process by an
interdisciplinary, international (Germany, Austria, Switzerland) expert group
representing the 20 member societies of the Joint Osteological Association (DVO)
and patient advocacy organizations (BfO). This manuscript summarizes the changes
in the German osteoporosis guideline with regard to pharmacological
interventions and offers pragmatic pathways for implementation.
Method Systematic literature search and structured consensus building
according to AWMF regulations.
Results The sclerostin antibody romosozumab was adopted into the
guideline. In addition, the effectiveness of teriparatide was re-evaluated. For
both bone anabolic agents evidence from randomized trials underlined a
superiority over oral bisphosphonates with regard to fracture risk reduction.
Between the antiresorptive treatments, differences regarding
superiority/inferiority could only be shown with respect to surrogate
parameters, not with regard to fractures. Data about the duration of treatment
of all available drugs is limited. All non-bisphosphonate treatments require
follow-up treatment.
Conclusion An individualized treatment concept should be developed in a
shared decision process, including a bone anabolic-first strategy in high-risk
patients. Recommendations on treatment duration, drug holidays and sequential
strategies should be considered.
Computer-assisted semen analysis in large falcons (Falco spp.)
and comparison to results of conventional semen analysis
Authors: Fischer Dominik , Schneider Helena , Meinecke-Tillmann Sabine , Wehrend Axel , Lierz Michael W. 
Published: May 2023

Abstract
Objective Numerous raptor species including some falcon species are facing
continuous population decline in the wild and some are threatened by extinction.
To support these species, captive breeding and reintroduction programs are
attempted. Besides conservation, some large falcon species are commonly used in
falconry and therefore bred commercially. Assisted reproduction is established
in falcon breeding since the 1970s and semen analysis is an integral part to
enable assessment of breeding males, inclusion or exclusion of semen donors and
quality control of semen prior to artificial insemination. Conventional methods
for semen analysis are widely used, but are time consuming and depend on the
investigator’s experience and ability. Computer-assisted semen analysis
(CASA) would offer an objective, fast and reproducible alternative, but as they
have not been established in large falcon species, this was the aim of this
study.
Material and methods To this end, we examined in 3 breeding seasons 109
semen samples of gyr-saker hybrid falcons (n=2) and peregrine falcons
(n=4) in 940 fields of view using the Minitube CASA SpermVision and
compared these results to results of conventional methods of semen analysis. We
used a preprogrammed setting and adapted two settings of CASA according to
specific semen characteristics of falcons.
Results Sperm velocity, motility and viability parameters were recorded
successfully using CASA. Correlation of conventional and computer-assisted
motility analysis improved during the process of adaptation of CASA settings,
but both methods differed significantly due to misinterpretation of round bodies
and semen impurities by CASA. Viability values of conventional and computer
assisted viability analysis using SYBR-PI correlated significantly while sperm
concentration did not at all.
Conclusion CASA failed to replace conventional semen analysis regarding
sperm motility and sperm concentration using 3 different settings, as a reliable
differentiation between spermatozoa, spermatids and round bodies was not
achieved.
Clinical relevance Using CASA, sperm velocity parameters were measured in
spermatozoa of captive-bred large falcons for the first time and may be used as
orientation values.
Behandlungsstrategie beim radiojodrefraktären differenzierten Schilddrüsenkarzinom
Authors: Mantsopoulos Konstantinos , Mueller Sarina K. , Pavel Marianne , Kuwert Torsten , Meidenbauer Norbert , Fietkau Rainer , Sievert Matti , Iro Heinrich 
Published: May 2023

ZusammenfassungTraditionell besteht das multimodale Therapiekonzept bei den differenzierten Schilddrüsenkarzinomen in der Thyreoidektomie mit Neck-Dissection (bei cN+-Halsstatus) und adjuvanten Radiojodablation mit abschließender risikoadaptierter TSH-Suppression. Das Ausmaß der Radiojodaufnahme beim metastasierten Schilddrüsenkarzinom spielt eine signifikante Rolle bei der Einschätzung der Prognose. Das fehlende Jodspeicherungsvermögen einer Läsion in Zusammenschau mit dem fehlenden Abfall des Tumormarkers Thyreoglobulin sowie radiologische Zeichen einer Tumorprogression charakterisieren den Radiojod-refraktären Patienten. Aufgrund des meistens über einen langen Zeitraum indolenten Verlaufs erscheint in den meisten Fällen ein abwartendes Verhalten in Kombination mit lokaler Metastasenbehandlung sowie Symptomlinderung primär sinnvoll zu sein. Der Nachweis einer Veränderung der Tumordynamik ist der Zeitpunkt, um eine Systemtherapie zu evaluieren. Diese beruht auf Multi-Tyrosinkinase-Inhibitoren (Sorafenib, Lenvatinib). Diese Substanzen sind größtenteils mit einem ungünstigen Nebenwirkungsprofil assoziiert (Diarrhö, Hautauschläge, arterielle Hypertonie mit hypertensiver Entgleisung, lokale Wundheilungsstörungen), welches zu einer nicht vernachlässigbaren Rate einer therapieassoziierten Morbidität sowie einer hohen Anzahl an Therapieunterbrechungen führt. Daher sind im Jahr 2020 2 selektive RET-Inhibitoren (Selpercatinib, Pralsetinib) für die differenzierten Schilddrüsenkarzinome von der FDA zugelassen worden. Eine neue Perspektive für die Zukunft wären die unterschiedlichen Redifferenzierungsstrategien, welche auf die Steigerung der Sensitivität der Tumorzellen auf Radiojod abzielen.
Brønsted Acid Catalyzed Asymmetric Silylation of Biaryl Diols
Authors: List Benjamin , Han Jung Tae , Zhou Hui 
Published: May 2023

AbstractWe report a Brønsted acid catalyzed enantioselective silylation of biaryl diols with an allylsilane as a silicon source. This process enables facile access to enantioenriched biaryl silyl ethers with an axial stereogenicity. A control experiment supports a mechanism proceeding by desymmetrization followed by kinetic resolution.
Video Occulography-Assisted Diagnosis of BPPV and Comparison of Pre- and Post-Intervention Dizziness Handicap Inventory Score
Authors: Khan Sidra , Agrawal Richa , Nivsarkar Sameer , Phatak Shrikant , Sikdar Abhik 
Published: May 2023

AbstractBenign paroxysmal positional vertigo (BPPV) is a commonly recognized vestibular disorder which is characterized by brief periods of vertigo and a characteristic nystagmus. The nystagmus is often difficult to appreciate with naked eyes and hence video oculography is a helpful tool. Dizziness Handicap Inventory is an objective way to assess the impact of vertigo on quality of life.
Objective Our study here aims at diagnosing undiagnosed, difficult and missed cases of BPPV using video-oculography and managing it with repositioning manoeuvre. This study also aims at measuring Dizziness Handicap Inventory Scores pre and post repositioning manoeuvre. We also observed the association between Vitamin D levels and the occurrence of BPPV.
Methods and Materials One hundred and twenty-six patients were enrolled in the age group of 18-70 years. After recognizing patients with BPPV, vertigo evaluation was performed. Those patients with suggestive history and suspicion of multiple canal involvement were taken for video-oculography.
Results Forty-four patients were in age group of 50-60 years, having female predominance. 35.71% cases which were missed on clinical examination were correctly diagnosed using video-oculography. The mean pre-intervention DHI was 41.29 ± 15.90 which lowered down to 14.84 ± 11.52 in post-intervention period. The highest DHI scores were seen in multi-canal BPPV involving lateral and posterior semi-circular canals.
Conclusion With the help of vide-oculography we could diagnose more cases of anterior and multi canal BPPV which are often missed. Maximum number of participants had insufficient levels of Vitamin-D and in our opinion correcting it would reduce the occurrence and recurrence rate..
A Systematic Review of Vestibular Evoked Myogenic Potential in Individuals with Motion Sickness
Authors: Furtal Silvestina Winston , Thomas Amith , Yerraguntla Krishna 
Published: May 2023

AbstractThe otolith of vestibular system in the human body helps in maintaining the static balance. Travelling can cause defect in static balance that may lead to motion sickness. The evidence showing the relation between vestibular evoked myogenic potential (VEMP) that assesses otolith function and motion sickness is contrasting. The current systematic review is aimed to understand outcomes of published articles in reporting association between vestibular evoked myogenic in individuals with motion sickness. For this study, the database used is PubMed, Scopus, ProQuest, CINHAL, and Web of Science. The data is extracted from the final articles where VEMP is done on individuals with and without motion sickness. The total articles included are 125 out of which five articles used for the systematic review. In this study, motion sickness susceptibility questionnaire is used to assess individuals with and without motion sickness. The latency and amplitude of both cervical VEMP (cVEMP) and ocular (oVEMP) of individuals with and without motion sickness are normal. However, the review indicates a significant change in the interaural asymmetry ratio of both cVEMP and oVEMP results in individuals with motion sickness. This shows that there might be a variation in the functional asymmetry in the otoliths. From the review, it is clear that there might be otolith changes due to motion sickness that can have a smaller impact on the interaural asymmetry ratio in VEMP. These findings can be further applied for the diagnostic purpose in individuals with motion sickness.
Awareness and Experience of Tinnitus in Nepalese Young Adult Population
Authors: Aryal Sajana , Bhatarai Prabuddha , Prabhu Prashant 
Published: May 2023

Abstract
Introduction The prevalence of tinnitus is increasing in younger adult rapidly. It is increasing mainly because of increased daily noise levels due to the unrestrained usage of recreational devices like mobile phones, MP3s, iPods, and other personal stereos. The aim of this study is to describe awareness and experience of tinnitus among younger adult with respect to the existence, cause, effects, and management.
Methods A descriptive cross-sectional study was conducted in 205 young adult Nepalese population between the age ranges between 20 and 40 years through online survey mode. Statistical analyses were carried out using SPSS 25.0 software. Data were analyzed using the descriptive statistics.
Results Result showed more than half of the participants (59.2%) were aware about the existence of tinnitus; however, only 16.1% of participants were aware about the effect of tinnitus. The incidence of tinnitus was found to be high (11.71%) in Nepalese population.
Conclusion Even though most of the participants were found to be aware about existence of tinnitus, most of them were not aware about the effect of tinnitus and its cause. This result has implications for audiologist who are involved in hearing health care program across the various age groups. As per this study, since most of the participants pointed to the Internet as their source of awareness, that could be further tapped on to provide awareness in these age groups.