bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydromorphone hydrochloride preconditioning combined with postconditioning attenuates myocardial ischemia/reperfusion injury in rats by improving mitochondrial function and activating the PI3K/Akt signaling pathway
Authors: Qiu Liuji , Yan Yan , Zhong Guocheng , Hou Zhiqi , Ye Yongcai , Lin Jiaying , Luo Dexing 
Published: September 2023

Abstract
Background Therapeutic methods such as thrombolytic therapy or percutaneous coronary intervention (PCI) can quickly restore blood flow in myocardial ischemic area. Thanks to these therapeutic methods, the death risk of acute myocardial infarction (AMI) has been reduced significantly. However, these therapeutic strategies may also cause myocardial ischemia/reperfusion injury (MIRI) and poor prognosis of patients. Previous studies have revealed protective effect of the opioid drug hydromorphone hydrochloride (HH) on brain ischemia/reperfusion injury (IRI) in rats and mice. However, there are few studies on the effect of HH on MIRI. Therefore, this study was designed to explore the protective effect and potential mechanism of HH on MIRI.
Methods Except Sham group, MIRI models were established by ligating and relaxing the left anterior descending coronary artery, and HH (0.3μmol/L) was injected through the tail vein 10 min before ligation (HH-pre group), 10 min after reperfusion (HH-post group) and twice at the above two time points (HH-pre+post group). After intervention, the cardiac function of rats was evaluated by echocardiography, and the serum of rats was collected for the detection of levels of myocardial injury markers. Next, the area of myocardial infarction was evaluated by 2,3,5-triphenyltetrazolium chloride (TTC) staining, followed by the measurement of levels of malondialdehyde (MDA), superoxide dismutase (SOD), lactate dehydrogenase (LDH), reactive oxygen species (ROS) and adenosine triphosphate (ATP). Besides, the relative content of mitochondrial DNA (mtDNA) was detected by qRT-PCR; mitochondrial biogenesis and phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)signaling pathway were evaluated by western blot.
Results Compared with the I/R group, rats in the HH-pre group, HH-post group and HH-pre+post group exhibited improved cardiac function, decreased myocardial infarction area, reduced serum myocardial injury markers, alleviated oxidative stress, improved mitochondrial function, up-regulated mitochondrial biogenesis and activated PI3K/Akt signaling pathway. Moreover, the HH-pre+post group was superior to the HH-pre group or the HH-post group in the above aspects.
Conclusion: HH has protective effect on MIRI. HH preconditioning combined with postconditioning shows optimal efficacy, and such efficacy may be achieved by promoting mitochondrial biogenesis to improve mitochondrial function and reduce oxidative stress, and activating the PI3K/Akt signaling pathway.
High-grade glioma in infants and very young children: characteristics, treatment, and outcomes
Authors: Arafah Omar , Maher Eslam , Mosaab Amal , Naguib Eman , Mohamed Amal , Ahmed Soha , Taha Hala , El-Beltagy Mohamed , El-Naggar Shahenda , El-Ayadi Moatasem 
Published: September 2023

Abstract
Purpose
High-grade gliomas (HGG) in infants and very young children (less than 3 to 5 years old) pose significant challenges due to the limited scientific literature available and high risks associated with treatments. This study aims to investigate the characteristics, treatment, and outcomes of this cohort.
Methods
A retrospective cohort study was conducted from 2007 to 2022 at Children’s Cancer Hospital, Egypt (CCHE-57357). Cases included children aged < 5 years old with pathologically confirmed CNS glioma grades III-IV. Baseline clinical and radiological characteristics, besides prognostic factors associated with survival, were assessed.
Results
In total, 76 cases were identified, 7 of them (9.2%) were < 1 year old, and 25 (32.9%) were aged 1 to 3 years. Most tumors were cerebral (55.3%). Gross- or near-total resection (GTR/NTR) was achieved in 32.9% of all cases. Of the tested cases, H3K27M-alteration was present in 5 subjects only. The 3-year OS and EFS for all cases were 26.9% and 15.4%, respectively. Extent of resection was the most important prognostic factor, as those achieving GTR/NTR experienced more than double the survival compared to those who do not (1-year EFS = 46.6% vs 21.4%, p=0.05). Age had a “bimodal” effect on EFS, with those aged 1 to 3 years old (1-year EFS = 40%) faring better than younger (EFS = 0%; p=0.02) and older age groups (1-year EFS = 28.1%; p=0.05). Subjects with midline tumors had worse survival compared to non-midline tumors (1-year EFS = 18.5% vs 35%, respectively, p=0.02).
Conclusion
This study in a large cohort of HGG in infants and very young children offers insights into the characteristics and treatment challenges. Extent of resection, age group, and tumor localization are important prognostic factors. Further research with larger sample size is warranted to refine treatment approaches and improve outcomes.
Implementing Community-Maternal and Perinatal Death Surveillance and Response to identify and prevent maternal and perinatal mortality in Kaduna State, Nigeria: Results and lessons from a pilot study
Authors: Tilton Alice , Ejembi Clara Ladi , Salawu Moshood , Aliyu Elkana , Shittu Oladapo , Matawal Punshak Watle , Olumeyan Shade , Abdulkarim Khadijah 
Published: September 2023

Abstract

Background: There is low utilisation of antenatal care, health
facility delivery, and post-natal care in Kaduna State, Nigeria,
contributing to high maternal and perinatal mortality. Our research
aimed to determine if community-Maternal and Perinatal Death
Surveillance and Response, inclusive of verbal and social
autopsies, increased antenatal care coverage (ANC), facility
deliveries, and postnatal care coverage (PNC).

Methods: Mixed methods were used to monitor and evaluate the
project. Data sources included health facility summary data from
January 2021 to December 2022, Key Informant Interviews (KIIs), and
Focus Group Discussions (FGDs) with health care workers from local
facilities and men and women from the two communities. Indicators
analysed included ANC coverage, skilled birth attendance rate, PNC
coverage and qualitative indicators linked to trust of healthcare
workers, blame for adverse events, and adoption of remedies to
modifiable causes of maternal and or perinatal deaths. Quantitative
and qualitative analyses were done on Microsoft Excel.

Results: Social autopsies were found to be acceptable and
valued by community members. Actions developed may have had a
lifesaving impact: maternity clinic run by an unskilled attendant
was closed down, 24-hour free transportation for pregnant women
provided by taxi drivers, and pre-emptive blood donations by
community members to support emergency preparedness for childbirth.
Qualitative data suggested that c-MPDSR led to increases in health
facility attendance for antenatal care, improved quality of care,
and increased trust between community members and health facility
staff.

Conclusions: c-MPDSR with verbal and social autopsies supports
communities in Kaduna State to identify and discuss the causes of
maternal and perinatal deaths and design actions that save lives
and improve the health of women and newborns.
Extreme coastal El Niño events are tightly linked to the
development of the Pacific Meridional Modes
Authors: Martinez-Villalobos Cristian , Dewitte Boris , Garreaud René 
Published: September 2023

Abstract

Coastal El Niño events —instances of anomalous ocean warming in the far eastern Tropical Pacific during basin-scale neutral or cold conditions— can have severe societal impacts for countries along the west coast of South America, as exemplified by the 2017 and 2023 Peru-Ecuador floods. Due to brevity of the observational record, it is not well understood whether these events are driven
by local or large-scale processes. Here, to overcome this limitation, we use a data-driven modeling approach to address their return period and forcing mechanisms. It is shown that extreme coastal El Niño events result from the constructive interactions of the Pacific Meridional Modes (PMM). Specifically, the North PMM yields a dipole-like anomaly SST pattern along the equator that favors its development, while the positive phase of the South PMM reinforces it. A smaller group of more moderate coastal events are remotely driven by zonal wind anomalies in
the western Tropical pacific without the PMMs’ influence. The role of PMMs in the development of extreme coastal El Niño suggests that they may be more predictable than previously thought.
Outcome of Chairside CAD/CAM Ceramic Restorations on Endodontically Treated Posterior Teeth: A Prospective Study
Authors: Hu Su-Ning , Li Jing-Wen , Zhang Xi-Xi , Wei Rong , Liang Yu-Hong 
Published: September 2023

Abstract
Objective: The aim of this study was to evaluate the outcome and risk factors for chairside CAD/CAM full cusp coverage restorations on endodontically treated posterior teeth after 3 years offollow-up.
Methods: A total of 246 endodontically treated posterior teeth of 226 patients were included and restored with CAD/CAM full cusp coverage all-ceramic restorations according to a standardized protocol. Patients were recalled after treatments 1 to 3 years and underwent clinical and radiological examinations. At recall, modified FDI criteria were used to determine treatment outcomes by 2 evaluators. Success was determined when FDI scores were 1-2, and failure was indicated when FDI scores were 5. Logistic regression analysis was performed to evaluate potential risk factors.
Results: 183 patients presented at recall, and the clinical outcomes of 201 teeth were analyzed with a recall rate of 82.0%for teeth and 81.7% for patients after 1-3 years offollow-up.187 of 201 teeth were found to have FDI scores of 1-2, and the success rate was 92%. No teeth were extracted during the follow-up period. Fourteenfailed cases with an FDI score of 5 presented restoration dislocation, fracture of restoration or/and tooth. Logistic regression analysis revealed that oral parafunction (OR 2.281, 95% CI 2.2~47.5, P value 0.01) was a risk factor for success rate.
Conclusion: Chairside CAD/CAM all-ceramic full cusp coverage restoration was (could be) a promising alternative for restoring endodontically treated posterior teeth.
COVID 19 vaccination as a trigger of acute genital ulcers in an autoimmune predisposed adolescent - a case report and literature review
Authors: Pokora Karolina , Kowalczyk Karolina , Cwynar Marlena , Peterek Robert , Stojko Rafał , Madej Paweł , Drosdzol-Cop Agnieszka 
Published: September 2023

Abstract
Acute genital ulcers (AGU) can affect girls and women of all ages. In children, they
often appear as an emergency and remain a diagnostic challenge for pediatricians,
gynecologists, and dermatologists. Prompt diagnosis and identification of disease-
related factors help to implement appropriate treatment. Firstly, it is crucial to properly
compile the medical background of the patient. Infectious, autoimmune, malignant,
traumatic, or vaccines are the possible conditions. Also, new infectious agents, such
as SARS-CoV-2 and vaccinations against it - COVID-19, may play a significant role
in the development of atypical clinical symptoms. We present a case of a 12-years-
old girl with acute genital ulcers and history of autoimmune diseases. She had
periodic fever - aphthous stomatitis - pharyngitis - adenopathy (PFAPA) syndrome
and Henoch-Schönlein purpura in the past. Additionally, she was vaccinated against
SARS-CoV-2 shortly before the lesions appeared. Review of literature is focused on
the possible causal link between appearance of AGU, autoimmunity, and COVID-19
vaccination.
SUMO1 mediated salubrinal-treated the abnormal remodeling of the subchondral bone in osteoarthritis
Authors: Li Xinle , Li Jie , Wu Qiu , Liu Daquan , Yokota Hiroki , Yang Lei , Zhang Ping 
Published: September 2023

Abstract
Background: Osteoarthritis (OA) is the most common joint disorder characterized by cartilage degradation and abnormal subchondral bone remodeling. As a post-translational modification, small ubiquitin-like modifiers (SUMOs) are involved in the pathogenesis of many diseases including arthritis. However, their role in OA remains to be elucidated. Furthermore, although salubrinal is reported to inhibit bone resorption and stimulate bone formation in osteoporosis, its effect on OA is not well understood.
Methods: To elucidate the role of salubrinal in OA and any linkage to SUMOylation, 54 mice were employed in 3 randomly assigned groups (n = 18), including the sham control (control), osteoarthritis (OA), and salubrinal-treated OA (OAS). OA was induced by transecting the medial collateral ligament and removing the medial meniscus. Salubrinal was administered subcutaneously at a dose of 2mg/kg daily for 2 weeks.
Results: Salubrinal reduced the osteoclast surface and elevated the osteoblast number in the trabecular subchondral bone. It also suppressed osteoclast activities and promoted osteoblast differentiation from bone marrow-derived cells. HE staining and CT imaging revealed that salubrinal improved the microstructure of the subchondral bone, and it reduced OARSI scores and CC/TAC. Silencing SUMO1 attenuated salubrinal’s beneficial effects on osteoclastogenesis and osteoblastogenesis.
Conclusions: Salubrinal improved the abnormal remodeling of the subchondral bone in OA, and its beneficial effects were partly mediated by SUMO1.
Bird detection Algorithm Incorporating Attention Mechanism
Authors: Liang Yuanqing , Wang Bin , Huang Houxin , Pang Hai , Yue Xiang 
Published: September 2023

Abstract

The safety of the substation is related to the stability of social order and people's daily lives, and the habitat and reproduction of birds can cause serious safety accidents in the power system. In this paper, to solve the problem of low accuracy rate when the YOLOv5l model is applied to the bird-repelling robot in the substation for detection, a C3ECA-YOLOv5l algorithm is proposed to accurately detect the four common bird species near the substation in real time: pigeon, magpie, sparrow and swallow. Four attention modules—Squeeze-and-Excitation (SE), Convolutional Block Attention Module (CBAM), an efficient channel attention module (ECA), and Coordinate Attention (CA)—were added to the backbone network at different times—after the C3-3 network layer, before the SPPF network layer, and in the C3 network layer (C3-3, C3-6, C3-9, and C3-3)—to determine the best network detection performance option. After comparing the network mean average precision rates (mAP@0.5), we incorporated the ECA attention module into the C3 network layer (C3-3, C3-6, C3-9, and C3-3) as the final test method. In the validation set, the mAP@0.5of the C3ECA-YOLOv5l network was 94.7%, which, after incorporating the SE, CBAM, ECA, and CA attention modules before the SPPF network layer following the C3-3 network layer of the backbone, resulted in mean average precisions of 92.9%, 92.0%, 91.8%, and 93.1%, respectively, indicating a decrease of 1.8%, 2.7%, 2.9%, and 1.6%, respectively. Incorporating the SE, CBAM, and CA attention modules into the C3 network layer (C3-3, C3-6, C3-9, and C3-3) resulted in mean average precision rates of 93.5%, 94.1%, and 93.4%, respectively, which were 1.2%, 0.6%, and 1.3% lower than that obtained for the C3ECA-YOLOv5l model.
An improved gray wolf optimizer for minimizing drilling deformation and residual stress in AA2024 sheet
Authors: Wu Rui , Huang Shiyao , Zhang Wenqian , Zhu Min , Zheng Zhong , Li Tao , Xue Huan 
Published: September 2023

Abstract

Aiming at the problem of large deformation and residual stress after drilling of aircraft skin Aluminum Alloy 2024 (AA2024) sheet, an Improved Gray Wolf Optimizer (IGWO) is proposed to optimize its fixture layout to make the deformation and residual stress smaller. A layout coding scheme is designed to obtain the maximum deformation and residual stress under different fixture layouts. Then a kriging prediction model is developed with a prediction error of 3.7% for deformation and 2.2% for residual stress. The model is integrated with the IGWO to provide a comprehensive set of optimal solutions. The specific improvements of IGWO included initializing the population with good point set to increase population diversity, incorporation of Lévy flight to prevent local optimum, adjustable distance control parameter tuning for balance the global and local searches, and optimizing the population by non-dominated sort and crowding distance. Ultimately, experimental studies and algorithmic comparisons are carried out to verify the efficacy of both the proposed model and the algorithm.
Life Activities of Elderly Patients With Operated Nonfunctional Pituitary Adenoma
Authors: kara zehra , Avcı Suna , Melikoglu Seçil Erden , Sulu Cem , Demir Ahmet Numan , Uysal Serhat , Özkaya Hande Mefkure , Kadıoğlu Pınar 
Published: September 2023

Abstract
Aim
To evaluate the clinical findings of nonfunctional pituitary adenomas (NFA) in the geriatric population, functional status, cognitive function, quality of life and frailty.
Material-Method
We evaluated operated NFA cases aged 65 years and older followed up in our clinic between 2010 and 2022. Patients seen in the geriatric outpatient clinic with a diagnosis of hypertension and diabetes mellitus were included in the study as a control group. Bioimpedance was used to assess muscle strength, walking speed, and muscle to fat ratio in patients. In addition, quality of life, anxiety, depression, cognitive function, and frailty were assessed.
Results
The study included 43 patients with NFA and 60 patients with hypertension (HT) and type 2 diabetes mellitus (DM) diagnoses. The mean age, sex ratios and body mass index (BMI) of the patients with NFA and the control group diagnosed with HT and type 2 DM were similar (age: 70.9±0.66; 73.1±0.8 (p=0,6), FM /M: 24/19, 35/25 (p=0.1) and BMI:28.3±3.9/28.5±4.8 (p=0.9), respectively). Cognition status (MMT: 28;29, p=0.002), frailty scores (2[2-3]; 1[1-2], M[IQR], p<0.001), sarcopenia rates (62%; 30%, p=0.007) was worse in patients with NFA.
Conclusion
In the study comparing patients diagnosed with surgical pituitary NFA with patients of similar age and comorbidity, the frailty score and rate of sarcopenia were higher and their cognition was worse.
Complications arising from surgical and postoperative treatment of patients with pituitary NFA make geriatric patients more frail. We emphasize that patients with NFA in this age group should be examined more carefully.
Forecasting of Daily Pan Evaporation Rate using Deep Learning Techniques for Three Different Agro-Climatic Regions of Chhattisgarh State
Authors: Majhi Babita , Naik Rupesh , Dash Sujata , Mallik Saurav , Al-Rasheed Amal , Abbas Mohamed , Soufiene Ben Othman 
Published: September 2023

Abstract

Accurate measurement or computation of evaporation loss is crucial for developing and successfully implementing water resource management strategies, irrigation planning, reservoir management, hydropower generation, drought and flood mitigation, urban planning and increasing agricultural productivity, especially in drought-prone areas. Evaporation can be measured directly using evaporimeters or forecasted using empirical models based on climatic variables such as temperature, humidity, wind speed, sunlight, and solar radiation, that influence the evaporation process. Modeling evaporation using climatic factors is difficult, especially when accounting for the wide range of agro-climatic conditions as it is an exceedingly nonlinear process. This paper uses different machine learning (ML) and deep learning algorithms to estimate pan evaporation (EP) for three distinct agro-climatic zones in the Indian state of Chhattisgarh. In this research, the performance of three machine learning models (Support Vector Machine, AdaBoost, and XGBoost) and four deep learning models (Deep Neural Network, Recurrent Neural Network, Long Short-Term Memory, and Bidirectional Long Short Term Memory) are evaluated and outcomes from each location are compared. Simulation results demonstrated that across all three regions, deep-Learning models outperform machine-learning and conventional models. Out of all deep learning models DRNN perform the best. As the results exhibit that the (EP) loss per day is less than 1 mm, the proposed model can be used for irrigation scheduling, water resource management which is very important for agriculture and its related activities.
Improved bioprocess for enhanced xylitol synthesis by newly isolate Meyerozyma caribbica (CP02)
Authors: Singh Saumya , Arya Shailendra Kumar , Krishania Meena 
Published: September 2023

Abstract

The present work models the fermentation process parameters of the newly isolated, Meyerozyma caribbica CP02 for enhanced xylitol production and its fermentability study on rice straw hydrolysate. The impact of process variables was initially studied one at a time each followed by statistical validation. Temperature 32°C, pH 3.5, 200 rpm, 1.5% (v/v) inoculum, 80 gL− 1 initial xylose was optimized and a sequential two-stage agitation in fermentation process was adopted. At optimized conditions, xylitol yield of 0.77 gg− 1 and 0.64 gg− 1 was actualized using media containing commercial and rice straw derived xylose, respectively. For scale up, in 3L batch bioreactor, the highest xylitol yield (0.63 gg− 1) was attained at 72 h with media containing rice straw derived xylose (59.22 gL− 1) along with inhibitors (1.82 gL− 1 aliphatic acids, 0.141 gL− 1 furans, 0.95 gL− 1 total phenols). This implies, M. caribbica CP02 demonstrated good hydrolysate fermentability even at high initial xylose concentration. Therefore, isolate CP02 has potential commercial feasibility in bio-refineries for high yield xylitol production with minimal hydrolysate processing.
Thermal evaluation of geometrical innovations in concentric and eccentric evacuated single and double solar collectors
Authors: Teles Mavd Paula , Lino Fatima A.M. , Silva Janayna Rocha , Nóbrega Claudia Rosa do Espirito Santo , Ismail Kamal A.R. 
Published: September 2023

Abstract
In this study, an experimental and numerical investigation of eight geometrical configurations of evacuated tube solar collectors was conducted. The configurations were tested simultaneously in outdoor installation under the same test conditions. The parameters such as collector eccentricity, solar concentration, vacuum, collector absorber, and cover tube materials were investigated. The numerical model developed in MATLAB was validated with experimental results. The results show that the eccentricity and the absorptivity of the material of the absorber are the parameters that have the highest influence on the collector performance. The use of reflective film in the eccentric solar collectors’ configurations can increase efficiency by 33%. The vacuum presented an efficiency increase variation between 1% and 4% in the eccentric tube collectors. For the concentric collectors configurations, the use of the vacuum between the tubes can reach an increase of 9% in its performance. The eccentricity of the collector using reflective film and vacuum allows an effective solar concentration in the collector absorber presenting a 26% higher efficiency when compared with the concentric collector.