bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return-to-school effects on suicide attempts in adolescents: a cross-sectional comparison between COVID-19 pre-pandemic and pandemic school semesters.
Authors: Gracia-Liso Rebeca , Portella Maria J , Pujals-Altés Elena , Puntí-Vidal Joaquim , Llorens Marta , Pàmias Montserrat , Fradera-Jiménez Marc , Montalvo-Aguirrezabala Itziar , Palao Diego 
Published: May 2023

Abstract
Background
The COVID-19 pandemic had and still have a major impact on adolescent mental health and consequently on suicidal behavior. However, few studies have investigated whether the pandemic has changed the patterns and the triggers of suicidality peaks in adolescents, e.g., seasonal patterns or family conflicts. We hypothesized that the pandemic modified suicidality rates: an increment of suicide attempts would be observed in the first semester of the academic year during COVID-19 pandemic compared to the same period of previous academic year; and the precipitating factors would be more related to social stressors during the pandemic school year.
Methods
A retrospective cross-sectional study was conducted to assess the precipitating factors, also including school-related factors and cognitive skills, of suicide attempts of adolescents occurred in the first and second semesters of the year before the pandemic lockdown (study periods 1 and 2) and the year after (study periods 3 and 4).
Results
The sample consisted of 85 adolescents aged between 12 and 17 recruited consecutively from March 2019 to March 2021 at emergency ward because of suicide attempt. Forty-eight adolescents (55.3% of the sample) were attended before the lockdown (pre-pandemic group) and 38 (44.7%) the year after. The results showed a higher proportion of suicide attempts in girls in period 4 (Sept 2020-Mar 2021) compared to the rest of periods (p = 0.026). The multinomial regression models showed a significant increase in the frequency of suicide attempts in the first semester of the pandemic academic year compared to the second semester of the pre-pandemic year, with depressive symptoms being a significant contributing factor (p = 0.04). Additionally, social triggers and age were found to be significant risk factors for suicide attempts in the first semester of the pandemic academic year compared to the same semester of the pre-pandemic year (p = 0.006 and p = 0.01, respectively).
Conclusions
During the pandemic, suicide attempts in girls increased more significantly in the first semester than in the previous year, and it was associated with greater severity of depressive symptoms. Social relations in back-to-school after the lockdown was a relevant trigger of suicide attempts in adolescents.
Structural and functional analysis of hyper thermostable ancestral L-amino acid oxidase that can convert Trp derivatives to D-forms by chemo-enzymatic reaction
Authors: Kawamura Yui , Ishida Chiharu , Miyata Ryo , Miyata Azusa , Hayashi Seiichiro , Fujinami Daisuke , Ito Sohei , Nakano Shogo 
Published: May 2023

Abstract
Establishing a reaction system to produce D-amino acids (D-AAs) on a large-scale has been required for now. In this study, we designed a novel L-amino acid oxidase, HTAncLAAO2, by ancestral sequence reconstruction, exhibiting high thermostability and long-term stability. The crystal structure of HTAncLAAO2 was determined at 2.2 Å by X-ray crystallography, revealing that the enzyme has an octameric form like a "ninja-star" feature. Enzymatic property analysis demonstrated that HTAncLAAO2 exhibits three-order larger kcat/Km values towards four L-AAs (L-Phe, L-Leu, L-Met, and L-Ile) than that of L-Trp. Through screening the variants, we obtained the HTAncLAAO2(W220A) variant, which shows >6-fold increase in kcat value toward L-Trp compared to the original enzyme. This variant applies to synthesizing enantio-pure D-Trp derivatives from L- or rac-forms at a preparative scale. Given its excellent properties, HTAncLAAO2 would be a starting point for designing novel oxidases with high activity toward various amines and AAs.
Acute Kidney Injury and Risk Factors in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation
Authors: Avcı Begüm , Bilir Özlem Arman , Özlü Sare Gülfem , Kanbur Şerife Mehtap , Gökçebay Dilek Gürlek , Bozkaya İkbal Ok , Bayrakçı Umut Selda , Özbek Namık Yaşar 
Published: May 2023

Abstract
Background Acute kidney injury (AKI) is common complication of hematopoietic stem cell transplantation (HSCT) with increased mortality and morbidity. Understading the risk factors for AKI is essential. The aim of this study is to identify AKI incidence, risk factors, and prognosis in pediatric post- HSCT patients.Methods We conducted a retrospective case-control study of 278 patients who were divided into two groups: those with AKI and those without AKI (Non-AKI). The groups were compared in terms of characteristics and clinical symptoms of patients, and post-HSCT complications, nephrotoxic drug use. Logistic regression analysis was applied to determine the risk factors for AKI.Results A total of 16.9% of patients had acute kidney injury, with 8.5% requiring kidney replacement therapy. Older age (OR 1.129, 95% CI 1.061-1.200, p < .001), sinusoidal obstruction syndrome (OR 2.562, 95% CI 1.216–5.398, p = .011), hemorrhagic cystitis (OR 2.703, 95% CI 1.178–6.199, p = .016), and nephrotoxic drugs, including calcineurin inhibitors, amikacin, and vancomycin (OR 17.250, 95% CI 2.329-127.742, p < .001), were identified as significant independent risk factors for AKI following HSCT. Mortality rate and mortality due to AKI were higher in stage 3 patients than those in stage 1 and 2 AKI (p = .019, p = .007, respectively). Chronic kidney disease developed in 1 patient (0.4%), who was in stage 1 AKI (2.1%).Conclusion AKI poses a serious threat to children post-HSCT, leading to alarming rates of mortality and morbidity. To enhance outcomes and mitigate these risks, it is vital to identify AKI risk factors, adopt early preventive strategies, and closely monitor this patient group.
Numerical and analytical estimation of rolling force and torque in hot strip rolling
Authors: Attanasio Aldo , Prete Antonio Del , Primo Teresa 
Published: May 2023

Abstract
In this paper, both numerical and analytical method were developed for computing, in strip or plate rolling, the distribution of roll pressure, rolling force and rolling torque (from which also rolling power can be estimated), assuming an homogeneous deformation of the rolled material. Differently to other similar models present in literature, which solve the resulting rolling differential equation for the roll pressure, the model presented in this work solves the problem for the horizontal force. In this way it is possible to avoid the calculation of the derivative of material flow stress curve, which is not always analytically easy and possible (i.e. point material flow stress data). The proposed numerical model is based on the friction law proposed by Chen and Kobayashi while the analytical one is based on simple shear friction model and brings to useful analytical formulas for a quickly calculation of rolling torque and force. Moreover, a relationship between the shear friction factor and Coulomb friction coefficient in rolling was found. The developed models show good agreement with experimental measures, in terms of rolling force and torque, found in literature.
Industrial Symbiosis and Circularization: Optimal Shelf Life of Waste-based Briquettes
Authors: Ossei-Bremang Rejoice Ntiriwaa , Adjei Eunice Akyereko , Kemausour Francis , Gyenin Eric Kwasi 
Published: May 2023

Abstract
The fusion of the circular economy and industrial symbiosis has several advantages from an economic and developmental standpoint. Cooking energy security issues in Africa can partly be solved by the utilization of waste resources in energy technology decisions such as briquetting. However, one of the limitations associated with waste-based briquettes has been identified as a reduction in efficiency when stored for a long period of time under varied storage conditions. The aim of this study was to ascertain the effects of storage time and exposure on the calorific value and mechanical characteristics of a waste-based composite briquette made from oil palm shell and decanter cake after 180 days of storage. The calorific value decreased by 12.99% and 31.40%, respectively, for sealed packaged storage and open-air storage. On the 180th day of the experiment, the packaged storage and the open-air storage registered 1000.48 Kg/m3 and 870 Kg/m3, 72.34% and 100%, 712% and 895%, and 118% and 143% for relaxed densities, shatter indices, resistance to impact, and hygroscopic properties respectively. Manufacturers within West Africa can adopt the findings in this study as a guide for their processes.
Privatization Decisions in a Mixed Duopoly under Endogenous Product Differentiation
Authors: Wang Fangyan , Munoz-Garcia Felix 
Published: May 2023

Abstract
We examine how endogenous product differentiation affects the behavior of a mixed duopoly market where a private firm competes with a partially privatized public firm under both Cournot and Bertrand competition. We also analytically derive the optimal degree of partial privatization of the public firm. Generally, privatizations increase the likelihood of no firm investing in equilibrium, resulting in markets with more homogenous goods. The public firm is more motivated to invest in product differentiation, particularly when prioritizing social welfare, while the private firm undertakes more investments when investments are not highly effective under Bertrand competition. We also demonstrate that a complete nationalization is not necessarily optimal in all contexts, and whether regulators privatize more or less depends on different market settings. Partial privatizations can enhance welfare when firms compete in quantities and investments in product differentiation are moderately effective. However, complete nationalization is socially optimal when firms compete in prices.
JEL classification: D43, L13, L32, L33
Synergistic Adsorption/Photodegradation of Ciprofloxacin by UV light-driven Nanocomposite Photocatalyst of Cu doped AC/TiO2: Experimental design via RSM-CCD.
Authors: Yaacob N. A. , Khasri A. , Ridzuan M. J.M. , Salleh N. H. M. , Chaijak P. 
Published: May 2023

Abstract
Improving the adsorption ability of titanium dioxide (TiO2) has been considered as a promising strategy to promote its photodegradation of pollutant for the wastewater treatment. Hence, the statistical optimization by using central composite design-response surface methodology for the synthesizing of Cu doped AC/TiO2 nanocomposite photocatalyst via microwave-assisted sol-gel method was prepared, and then applied in adsorption/photodegradation for Ciprofloxacin (CFx) removal. From analysis of variance analysis, the findings show 95 % removal of CFx within 120 min in a batch system at the optimum preparation parameters of AC/TiO2 ratio = 0.50, Cu dosage = 0.32 g, irradiation power = 477 W, and irradiation time = 14 min. Kinetic studies displayed that the kinetic data was well described by Pseudo second-order models. Also, the isotherms data was well fitted by Langmuir model, with maximum adsorption capacity of 200 . Radical quenching test indicated that hydroxyl radical (•OH) was found to be the reactive radical that generally play the primary role in adsorption/photodegradation of CFx removal. The synergetic mechanisms of adsorption/photodegradation of CFx removal by Cu doped AC/TiO2 nanocomposite photocatalyst was mainly done by photogenerated electron-hole pair and hydroxyl radicals. The results of this study indicated that the prepared Cu doped AC/TiO2 nanocomposite photocatalyst is a high potential of sustainable photocatalyst for CFx removal in aqueous solution using adsorption/photodegradation under UV light irradiation.
Online questionnaire based evaluation of knowledge, attitude and practices (KAP) regarding dengue fever among local people of Karachi, Pakistan.
Authors: Ali Muhammad , Khan Quratulain , Nawaz Shoaib , Naz Sharmeen , Bilal Muhammad , Abbas Mahnoor 
Published: May 2023

Abstract
Dengue fever is a very common viral disease in Pakistan. It is a major public health issue whose epidemiology and ecology is strongly related to human lifestyle and activities. Current study aimed at evaluation of Knowledge, attitude and practices regarding dengue fever among people of Karachi, Pakistan. A questionnaire based cross sectional study was conducted between February-April 2022. Questionnaire was prepared and adapted from previous literature available and it was designed on Google forms. This questionnaire was distributed randomly through various social media networks. Questionnaire had four sections which included socio-demographic data of all Participants, questions about knowledge, attitude and practice of dengue fever. Data was evaluated statistically (descriptive statistics) using SPSS software version 25. A total of 140 respondents filled the Google survey form. Out of 140 respondents or participants (42.9%) were male and (57.1%) were female. Majority of participants (80%) were between age group of 15–30 years. Participants have different educational status i.e. undergraduate participants were 57.1% and postgraduate were 32.9%. Majority of participants were single (72.1%) and students (70%). Ninty percent of people reported that they had heard about dengue fever. Dengue as a viral disease was reported by 72.1% but still 50.7% thought that antibiotics are used as treatment of dengue fever. Panadol reduces the intensity of dengue fever was reported by 49.3% respondents. Only 26.4% respondents participated in awareness programs related to dengue fever. Positive perception regarding visit to a physician after getting dengue fever was given by 74.3%. The knowledge about dengue fever was adequate in local community or people of Karachi, Pakistan, while the attitude and practices regarding life style modification requires immediate improvements. Good knowledge doesn't necessarily lead to good practice and positive perception. It is high time that awareness and educational campaigns on dengue fever should be designed by government to improve behavior and practices of prevention and control of dengue fever.
The place of antispasmodic drugs in modern therapy of irritable bowel syndrome
Authors: Khalaidzheva K. N. , Drozdov V. N. , Shikh E. V. , Serebrova S. Yu. 
Published: May 2023

Irritable bowel syndrome (IBS) is a common functional disease of the gastrointestinal tract, affecting a large number of adults worldwide, and leads to a significant decrease in the quality of life. IBS places a heavy burden on patients, most of whom are able-bodied population, as well as doctors and the healthcare system. The pathogenesis of this disease is multifactorial and includes the brain-intestine axis, disorders of the immune function of the mucous membrane, visceral hypersensitivity, changes in the motility of the gastrointestinal tract, changes in the microbial composition of the intestine. Based on the fact that changes in intestinal motility and visceral hypersensitivity are among the key factors in the pathogenesis of the disease, he use of antispasmodic drugs as part of complex therapy is justified. Mebeverin is a myotropic antispasmodic drug recommended for use in patients with IBS according to Rome IV Criteria, as well as clinical recommendations of the Russian Gastroenterological Association and the Association of Coloproctologists of Russia. According to available data, mebeverin has proven to be an effective and safe antispasmodic used to treat patients with IBS. The article presents a clinical case demonstrating the experience of effective use of the drug Mebespalin®. A patient with a diagnosis of IBS with a predominance of constipation is recommended to take an antispasmodic, as well as lifestyle modification – the addition of fiber-rich foods, sufficient drinking regime and increased physical activity. A week after the start of treatment, the patient noted an improvement in her condition – abdominal pain did not bother, the stool normalized.
The influence of structural and functional albumin properties on the life quality in patients with decompensated liver cirrhosis
Authors: Turkina A. A. , Maevskaya M. V. , Zharkova M. S. , Ivashkin V. T. 
Published: May 2023

Introduction. The gradual progression of liver cirrhosis with the development of complications has a negative impact on the life quality of patients with this disease. Modern therapeutic strategies are aimed not only at disease compensating, but much attention is paid to improving the quality of life. No data exists on the effect of serum albumin levels, their structural and functional activity, on the quality of life of patients with cirrhosis. Aim. To evaluate the relationship between serum albumin concentration, its structural configuration (DR), functional properties (BE, RTQ, DTE) and life quality in patients with decompensated liver cirrhosis. Materials and methods. The severity of the structural and functional properties of albumin was evaluated in decompensated patients (n = 50) using electron paramagnetic resonance spectroscopy (EPR spectroscopy). Patients’ quality of life was examined using a standardised SF-36 questionnaire.Results. Pathological changes in DR were observed in 100% of patients, a decrease in BE – in 90%, a violation of RTQ – in 82% of cases, a decrease in DTE was recorded in 76% of patients. The correlation between the level of serum albumin and indicators of physical functioning (PF), role functioning due to emotional state (RE) was ρ = 0,294. Structural and functional albumin properties were related to low indicators of the physical component of health (p < 0,05). Conclusions. А decline in serum albumin levels, a violation of its conformation and functional properties has a negative impact on the quality of life of patients with decompensated liver cirrhosis.
Antacids in real clinical practice
Authors: Trukhan D. I. , Degovtsov E. N. , Novikov A. Yu. 
Published: May 2023

Currently, proton pump inhibitors (PPIs), H2-histamine receptor blockers (H2-blockers), antacids, and anticholinergics are used to treat acid-dependent diseases of the gastrointestinal tract. PPIs are considered the most effective drugs for the treatment of acid-dependent diseases of the gastrointestinal tract. However, in real clinical practice, interest remains in the use of antacids in acid-dependent diseases. This is due to the fact that antacids not only adsorb hydrochloric acid in the gastric lumen (by buffering the HCl present in the stomach, without a significant effect on its production) and reduce the proteolytic activity of gastric juice (reducing/ neutralizing the activity of pepsin), but also have a number of other pharmacotherapeutic properties demanded by the gastroenterological patient. Antacids in addition to antisecretory action have: 1) cytoprotective, primarily gastroprotective, action, which is mediated by: a) stimulation of the synthesis of bicarbonates and prostaglandins; b) mucoprotection – an increase in the production of protective mucus by epithelial cells; c) switching of the epithelial growth factor and its concentration in the area of erosive and ulcerative defects, which in turn activates angiogenesis, cell proliferation and local reparative and regenerative processes; 2) enveloping and adsorbing action, through chelation of lysolecithin and bile acids, which have an aggressive damaging effect on the upper gastrointestinal tract; 3) regulate gastroduodenal motility due to: a) antispasmodic action and streamlining gastroduodenal evacuation; b) decrease in intracavitary pressure in the stomach and duodenum; b) obstacles to the formation of duodenogastric reflux. To date, combined preparations, the basic composition of which includes magnesium hydroxide and aluminum hydroxide, meet the basic requirements for non-absorbable antacids. In conclusion, the authors present a number of clinical situations, indicating that today rationally prescribed antacid drugs successfully and significantly solve the main tasks of symptomatic therapy of acid-dependent and other diseases of the gastrointestinal tract, significantly improving the quality of life of patients.
Microplastic pollution of drinking water in a metropolis
Authors: Buyukunal Serkan Kemal , Koluman Ahmet , Muratoglu Karlo 
Published: May 2023

Abstract

This study was conducted to identify microplastics (MPs) in drinking water from various sources in İstanbul that are known to pose potential health risks. One hundred drinking water samples were analysed. Samples were filtered with a glass filter (Ø: 1.0 μm). After filtration, microscopy was used, followed by SEM-EDS and ATR-FTIR identification to characterise MPs. Two shapes (fibers and fragments) and eight polymer types of MPs (ethylene propylene, neoprene, polyethylene, polyethylene terephthalate, polypropylene, polyvinyl chloride, polytetrafluoroethylene, vinyl chloride vinyl acetate copolymer) with sizes of 12–4892 µm (548 ± 777 µm) were detected. These MPs abundances ranged from 10 to 390 MP L−1 (134 ± 93 MP L−1). In the identification of MPs detected in filters by FTIR spectroscopy, bisphenol A, which is used in the production of various plastics and described as an important public health problem, was detected in 9.74% of MPs. Within the scope of the Sustainable Development Goals, UNEP has a specific objective of ensuring access to safe, affordable drinking water (SDG 6). With a clear statement, it should be emphasised that MPs are a significant barrier to the provision of safe drinking water, and a comprehensive plan for overcoming this barrier should be developed.
Effectiveness of the Neuroimaging Techniques in the Recognition of Psychiatric
Disorders: A Systematic Review and Meta-analysis of RCTs
Authors: Wu Jun , Xiao Jian 
Published: May 2023

Background:
Neuroimaging has helped us learn about the stages of brain development from infancy to maturity. Neuroimaging helps physicians diagnose mental illnesses and find novel treatments for them. It can distinguish depression from neurodegenerative diseases or brain tumors, and it can reveal structural defects that cause psychosis. Psychosis has been linked to lesions in the frontal or temporal lobes of the brain, as well as the thalamus and hypothalamus, which can be detected using a brain scan for mental illnesses. Neuroimaging uses quantitative and computational methods to explore the central nervous system. It can detect brain injuries and psychological illnesses. Thus, a systematic review and meta-analysis of randomized controlled trials using neuroimaging to detect psychiatric disorders assessed their efficacy and benefits.

Materials and Methods:
Appropriate articles were searched from PubMed, MEDLINE, and CENTRAL databases using the appropriate keywords as per the PRISMA guidelines. Randomized controlled trials and open-label studies were included as per the predefined PICOS criteria. Meta-analysis was performed using the RevMan software, and statistical parameters like odds ratio and risk difference were calculated.

Results:
Twelve randomized controlled clinical trials with a total of 655 psychiatric patients were included following the criteria from the year 2000 to
2022. We included studies that use different neuroimaging techniques for the detection of organic brain lesions that would help diagnose
psychiatric disorders. The primary outcome was detecting brain abnormalities in diverse psychiatric illnesses with neuroimaging versus
conventional methods. We found the odds ratio value of 2.29 (95% CI 1.49-3.51). The results were heterogeneous with a Tau2 value of 0.38, chi2
value of 35.48, df value of 11, I2 value of 69%, the z value of 3.78, and p-value less than 0.05. The risk difference is 0.20 (95% CI 0.09 -0.31) with
heterogeneity of Tau2 value of 0.03, chi2 value of 50, df value of 11, I2 value of 78%, the z value of 3.49, and p-value less than 0.05.

Conclusion:
The present meta-analysis strongly recommends the use of neuroimaging techniques for the detection of psychiatric disorders.