bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway
Authors: Xuan Yuan Han-Ning , Kim Hyun Sung , Park Gye Ryeol , Ryu Jae Eun , Kim Ji Eun , Kang In Young , Kim Hye Young , Lee Seung Min , Oh Ju Hee , Yoon Eileen L , Jun Dae Won 
Published: January 2025

BACKGROUND
Mixed lineage kinase domain-like protein (MLKL) serves as a critical mediator in necroptosis, a form of regulated cell death linked to various liver diseases. This study aims to specifically investigate the role of MLKL’s adenosine triphosphate (ATP)-binding pocket in facilitating necroptosis-independent pathways that may contribute to liver disease progression. By focusing on this mechanism, we seek to identify potential therapeutic targets that can modulate MLKL activity, offering new strategies for the prevention and treatment of liver-related pathologies.
AIM
To investigate the possibility of using the ATP-binding pocket-associated, necroptosis-independent MLKL pathway as a target for liver diseases.
METHODS
Cell death following necroptosis stimuli was evaluated using cell proliferation assays, flow cytometry, and electron microscopy in various cells. The human liver organoid system was used to evaluate whether the MLKL ATP pocket-binding inhibitor could attenuate inflammation. Additionally, alcoholic and non-alcoholic fatty liver diseases animal models were used to determine whether MLKL ATP pocket inhibitors could attenuate liver injury.
RESULTS
While an MLKL ATP pocket-binding inhibitor did not prevent necroptosis-induced cell death in RAW 264.7 cells, it did reduce the necroptosis-led expression of CXCL2 , ICAM , and VCAM . Notably, MLKL ATP pocket inhibitor diminishes the expression of CXCL2 , ICAM , and VCAM by inhibiting the IκB kinase and nuclear factor kappa-B pathways without inducing necroptosis-induced cell death in two-dimensional cell culture as well as the human-derived liver organoid system. Although MLKL ATP-binding inhibitor was ineffective in non-alcoholic fatty liver disease animal models, MLKL ATP-binding inhibitor attenuated hepatic inflammation in the alcoholic liver disease model.
CONCLUSION
MLKL ATP pocket-binding inhibitor exerted anti-inflammatory effects through the necroptosis-independent MLKL pathway in an animal model of alcoholic liver disease.
Prognostic roles of the prognostic nutritional index in patients with resectable and advanced biliary tract cancers
Authors: Zeng Di , Wen Ning-Yuan , Wang Yao-Qun , Cheng Nan-Sheng , Li Bei 
Published: January 2025

BACKGROUND
Biliary tract cancer (BTC) is a rare, aggressive malignancy with increasing incidence and poor prognosis. Identifying preoperative prognostic factors is crucial for effective risk-benefit assessments and patient stratification. The prognostic nutritional index (PNI), which reflects immune-inflammatory and nutritional status, has shown prognostic value in various cancers, but its significance in BTC remains unclear.
AIM
To assess the prognostic value of the preoperative PNI in BTC patients, with a focus on overall survival (OS) and disease-free survival (DFS).
METHODS
Comprehensive searches were conducted in the PubMed, EMBASE, and Web of Science databases from inception to April 2024. The primary outcomes of interest focused on the associations between the preoperative PNI and the prognosis of BTC patients, specifically OS and disease-free survival (DFS). Statistical analyses were conducted via STATA 17.0 software.
RESULTS
Seventeen studies encompassing 4645 patients met the inclusion criteria. Meta-analysis revealed that a low PNI was significantly associated with poorer OS [hazard ratio (HR) 1.91, 95%CI: 1.59-2.29; P < 0.001] and DFS (HR 1.93, 95%CI: 1.39-2.67; P < 0.001). Subgroup analyses revealed consistent results across BTC subtypes (cholangiocarcinoma and gallbladder cancer) and stages (resectable and advanced). Sensitivity analyses confirmed the robustness of these findings, and no significant publication bias was detected.
CONCLUSION
This study demonstrated that a low preoperative PNI predicts poor OS and DFS in BTC patients, highlighting its potential as a valuable prognostic tool. Further prospective studies are needed to validate these findings and enhance BTC patient management.
Procalcitonin and presepsin for detecting bacterial infection and spontaneous bacterial peritonitis in cirrhosis: A systematic review and meta-analysis
Authors: Wejnaruemarn Salisa , Susantitaphong Paweena , Komolmit Piyawat , Treeprasertsuk Sombat , Thanapirom Kessarin 
Published: January 2025

BACKGROUND
Diagnosing bacterial infections (BI) in patients with cirrhosis can be challenging because of unclear symptoms, low diagnostic accuracy, and lengthy culture testing times. Various biomarkers have been studied, including serum procalcitonin (PCT) and presepsin. However, the diagnostic performance of these markers remains unclear, requiring further informative studies to ascertain their diagnostic value.
AIM
To evaluate the pooled diagnostic performance of PCT and presepsin in detecting BI among patients with cirrhosis.
METHODS
We performed a systematic search of the MEDLINE, EMBASE, and Scopus databases for studies that evaluated the diagnostic role of PCT and presepsin from inception to June 2024. Sensitivity and specificity values were pooled using a random effects model. BI was diagnosed based on clinical manifestations, physical examination, laboratory data, and radiological findings.
RESULTS
Of the 6639 articles retrieved, 28 met the inclusion criteria and included 4287 patients with 1789 cases of BI (41.7%). The bivariate pooled sensitivity and specificity estimates of PCT for BI diagnosis were 0.73 [95% confidence interval (CI): 0.64-0.81] and 0.83 (95%CI: 0.79-0.87), respectively. The diagnostic odds ratio (DOR) of PCT was 17.21 (95%CI: 9.57-30.95). Presepsin showed a pooled sensitivity of 0.75 (95%CI: 0.60-0.86), specificity of 0.80 (95%CI: 0.68-0.88), and DOR of 12.33 (95%CI: 5.10-29.83) for diagnosing BI. The pooled sensitivity and specificity of PCT for diagnosing spontaneous bacterial peritonitis (SBP) were 0.76 (95%CI: 0.67-0.84) and 0.87 (95%CI: 0.78-0.92), respectively. The positive likelihood ratio of PCT was 5.57 (95%CI: 3.34-9.29), which was sufficiently indicative of SBP. The DOR of PCT was 29.50 (95%CI: 12.30-70.80).
CONCLUSION
PCT and presepsin have high sensitivity and specificity for detecting BI in patients with cirrhosis. Furthermore, PCT has good diagnostic value as a rule-in test for SBP diagnosis.
Индивидуальный подход в хирургическом лечении генитального пролапса у женщин: сравнительный анализ методов и результаты лечения
Authors: Меирманова А.О. , Омарова Г.К. , Бегниязова Ж.С. , Юлдашева А.И. , Уалиева А.Е. , Велиева А.Т. , Диамбекова Л.С. , Хампиева Л.М. , Нашекенова З.М. 
Published: January 2025

Аннотация
Актуальность. Генитальный пролапс представляет собой распространенное заболевание среди женщин пери- и постменопаузального возраста, которое оказывает значительное негативное влияние на качество их жизни. Современные методы хирургического лечения, такие как влагалищная гистерэктомия и лапароскопически ассистированная вагинальная гистерэктомия, доказали свою эффективность. Однако частота рецидивов и осложнений при стандартных подходах подчеркивает необходимость индивидуализации лечения, учитывающей анатомические, возрастные и социальные особенности пациенток.
Цель. Изучить преимущества индивидуального подхода к хирургическому лечению генитального пролапса у женщин пери- и постменопаузального возраста, а также провести сравнительный анализ двух методов хирургической коррекции.
Методы. В исследовании участвовали 195 пациенток с генитальным пролапсом III-IV степени. Проведен сравнительный анализ влагалищной гистерэктомии и лапароскопически ассистированной вагинальной гистерэктомии с пластикой тазового дна. Оценивались такие показатели, как длительность операций, уровень кровопотери, частота осложнений, качество жизни пациенток через 1, 3 и 6 месяцев после лечения, а также частота рецидивов. Статистическая обработка данных выполнена с использованием методов описательной и сравнительной статистики.
Результаты. Лапароскопически ассистированная вагинальная гистерэктомия продемонстрировала более высокую эффективность, чем влагалищная гистерэктомия, включая снижение частоты рецидивов (5% против 10%) и улучшение качества жизни пациенток через 6 месяцев (самооценка 4,0 против 3,5 баллов). Однако метод ЛАВГ характеризуется увеличенной длительностью операций и более высоким уровнем кровопотери. Осложнения отмечены в 5% случаев после ЛАВГ и отсутствовали в группе ВГ.
Заключение. Индивидуализированный подход к лечению генитального пролапса позволяет повысить эффективность хирургических вмешательств, снизить частоту рецидивов и улучшить качество жизни пациенток. Применение лапароскопически ассистированных методов рекомендуется пациенткам с высоким риском осложнений или рецидивов, несмотря на их большую трудоемкость.
Ключевые слова: генитальный пролапс, влагалищная гистерэктомия, лапароскопическая хирургия, качество жизни, индивидуализированный подход, рецидивы, осложнения.
The Concept of Profit Sharing Agreement in Land Management in Segara Kodang, Sesetan Village, South Denpasar District, Denpasar City
Authors: UTAMA Kartika Jaya , SUKANDIA I Nyoman , AGUNG Anak Agung Istri , DEWI Ida Ayu Permata Winditya , YUDHA I Putu Wira Dharma Putra 
Published: January 2025

The importance of the meaning of soil for human life is because human life is utterly inseparable from the soil. They live on the land and obtain food by utilizing the land. The amount of land that can be controlled by humans can be reduced due to erosion, while the number of people who wish for land is constantly increasing. In answering legal problems, this research uses an empirical method. The people of Sesetan Village use customary Law passed down from generation to generation, carried out orally based on trust and agreement, and no deed is made from these legal acts. The implementation of the profit-sharing agreement can be carried out well with the existence of a trust system between the customary village institution and the community in maintaining the agreement as well as knowing and implementing their respective rights and obligations agreed upon at the time of making the agreement which aims to improve the economy of the community in the use of village land and especially the customary Village itself.
Detectability of Self-lensing Flares of White Dwarfs with Compact Companions
Authors: Nir Guy , Bloom Joshua S. 
Published: January 2025

Abstract
Binaries containing compact objects, viewed nearly edge on, can produce periodic brightening events under certain conditions on the masses, radii, and binary separation. Such flares are caused by one object gravitationally lensing another, in what is known as self-lensing flares. We present a simulation tool that efficiently reproduces the main features of self-lensing flares and facilitates a detection sensitivity analysis for various sky surveys. We estimate the detection prospects for a handful of representative surveys when searching for systems of either two white dwarfs or a white dwarf with other compact objects, i.e., neutron stars and black holes. We find only a marginal ability to detect such systems in existing surveys. However, we estimate many such systems could be detectable by surveys in the near future, including the Vera Rubin Legacy Survey of Space and Time (LSST). We provide a quantitative analysis of the detectability of double-compact object self-lensing flares across the landscape of system parameters, and a qualitative discussion of survey and follow-up approaches to distinguish such flares from confounding events, such as stellar flares, satellite glints, and cosmic rays. We estimate 0.3, 3 and 247 double white dwarf systems could be detected by Transiting Exoplanet Survey Satellite, Zwicky Transient Facility, and LSST, respectively. A similar number of systems with a neutron star or black hole companion could be detected, but we caution that the number densities of such binaries is model dependent and so are our detection estimates. Such binaries can be used to constrain models of the end states of binary evolution.
The Long-term Evolution of the Solar Transition Region
Authors: Chen W. Q. , Li K. J. , Xu J. C. 
Published: January 2025

Abstract
Long-term evolution characteristics of the solar transition region have been unclear. In this study, daily images of the solar full disk derived from the observations by the Solar Dynamics Observatory/Atmospheric Imaging Assembly at 304 Å wavelength from 2011 January 1 to 2022 December 31 are used to investigate the long-term evolution of the solar transition region. It is found that long-term variation in the transition region of the full disk is in phase with the solar activity cycle, and thus the polar brightening should occur in the maximum epoch of the solar cycle. Long-term variation of the background transition region is found to be likely in antiphase with the solar activity cycle at middle and low latitudes. The entire transition region, especially the active transition region is inferred to be mainly heated by the active-region magnetic fields and the ephemeral-region magnetic fields, while the quieter transition region is believed to be mainly heated by network magnetic fields. Long-term evolution characteristics of various types of the magnetic fields at the solar surface are highly consistent with these findings, and thus provide an explanation for them.
Kinematics of Young Stellar Objects under Various Stellar Feedback
Authors: Yang Longhui , Liu Dejian , Hao Chaojie , Lin Zehao , Li YingJie , Dong Yiwei , Lu Zu-Jia , Liang En-Wei , Xu Y. 
Published: January 2025

Abstract
Based on the Gaia Data Release 3 and APOGEE data sets, we investigate the kinematic differences between young stellar objects (YSOs) and their parent clouds in five nearby star-forming regions. Overall, the one-dimensional velocity differences between Class II YSOs and their parent molecular cloud range from [0, 1.4] km s−1. In feedback environments dominated by outflows, massive stars, and supernova feedback, the corresponding velocity differences range from [0, 1.4], [0.1, 0.4], and [0.1, 1] km s−1, respectively. These results indicate that YSO kinematics are not significantly affected by these different types of feedback environments. Additionally, compared to the Class II YSOs, Class III YSOs have slightly larger velocities and dispersions.
Polarization Reconstruction Study of Wide Field-of-view Photoelectric Polarimeter for POLAR-2/LPD
Authors: Feng 冯 Zu-Ke 祖科 , Liu 刘 Hong-Bang 宏邦 , Yi Di-Fan , Xie Li-Rong , Dai Cong , Feng Huan-Bo , Sun Jian-Chao , He Jiang , Wang Yuan-Hao , Ma Rui-Ting , Wang Bin-Long , Mai Qian-Nan , Tuo Jiang-Chuan , Zhong Qian , Tang Zhen-Yu , Liu Qian , Xie Fei , Zhang Shuang-Nan , Liang En-Wei 
Published: January 2025

Abstract
The Low-Energy X-ray Polarization Detector (LPD) is one of the payloads in the POLAR-2 experiment, which is planned as an external payload for deployment on the China Space Station in 2026. The LPD is specifically designed to observe the polarization of gamma-ray burst prompt emissions in the energy range of 2–10 keV, with a preliminary design featuring a wide field-of-view (FOV) of ±45°. This observation is achieved using an array of X-ray photoelectric polarimeters. Because of the wide FOV design of the detector, nearly all photons impinge on the detector off-axis. This paper investigates the polarization reconstruction of a photoelectric polarimeter for off-axis photons. It was found that the reconstruction of the emission azimuthal angles of photoelectron tracks is the main factor affecting the shape of the modulation function for off-axis radiation. Therefore, a modulation function correction method based on Monte Carlo (MC) simulation is proposed. This MC simulation-based method is applied to both simulated and experimental data to correct the modulation function for off-axis radiation. The reconstruction results demonstrate that this method can accurately determine the polarization degree and polarization angle of photons under different conditions. While we tested up to 45° off-axis angles due to our ±45° FOV, the method is theoretically applicable to off-axis angles up to ∼90°.
Effective Resistivity in Relativistic Reconnection: A Prescription Based on Fully Kinetic Simulations
Authors: Moran Abigail , Sironi Lorenzo , Levis Aviad , Ripperda Bart , Most Elias R. , Selvi Sebastiaan 
Published: January 2025

Abstract
A variety of high-energy astrophysical phenomena are powered by the release—via magnetic reconnection—of the energy stored in oppositely directed fields. Single-fluid resistive magnetohydrodynamic (MHD) simulations with uniform resistivity yield dissipation rates that are much lower (by nearly 1 order of magnitude) than equivalent kinetic calculations. Reconnection-driven phenomena could be accordingly modeled in resistive MHD employing a nonuniform, “effective” resistivity informed by kinetic calculations. In this work, we analyze a suite of fully kinetic particle-in-cell (PIC) simulations of relativistic pair-plasma reconnection—where the magnetic energy is greater than the rest mass energy—for different strengths of the guide field orthogonal to the alternating component. We extract an empirical prescription for the effective resistivity,

η
eff

=
α

B
0

∣
J

∣
p

/

∣
J

∣

p
+
1

+

e

n
t

c

p
+
1

, where B
0 is the reconnecting magnetic field strength,
J
is the current density, n

t
is the lab-frame total number density, e is the elementary charge, and c is the speed of light. The guide field dependence is encoded in α and p, which we fit to PIC data. This resistivity formulation—which relies only on single-fluid MHD quantities—successfully reproduces the spatial structure and strength of nonideal electric fields and thus provides a promising strategy for enhancing the reconnection rate in resistive MHD simulations.
Going Dutch: Invasion pathways and current European distribution of non-native land flatworm species belonging to Geoplaninae and Bipaliinae with focus on the Netherlands
Authors: de Waart Sytske , Vanhove Maarten , Kmentová Nikol , Justine Jean-Lou 
Published: January 2025

Non-native land flatworms can have a negative impact on local ecosystems, due to their ferociousness in hunting earthworms or snails. Accurate knowledge on the distribution of non-native populations of land flatworms is necessary to design effective policy to control their spread across Europe. The aim of this study is to address the spatiotemportal distribution of selected species of non-native land flatworms (Geoplaninae and Bipaliinae) in the Netherlands, and provide their current distribution and introduction pathways in a pan-European perspective.
Specimens of Obama spp., Bipalium kewense and Diversibipalium multilineatum were reported across selected Dutch gardens, greenhouses, plant nurseries or garden centers. European distribution of these planarians species was reconstructed using previously published datasets and from records available on GBIF. Morphological species identification was supported by DNA barcoding using a portion of the 28S rDNA marker. Introduction pathways were addressed via haplotype networks based on COX1 mtDNA.
In total, 27 specimens of non-native land flatworms were collected in the Netherlands. Their different spatiotemporal distribution pattern indicates differences in tolerance to environmental conditions in Northern Europe between B. kewense restricted to greenhouses and D. multilineatum found in gardens. Generally, an increasing trend in the number of total records of O. nungara is observed in the Netherlands and in Europe, with the highest number of records per country reported in France (1.428) followed by the Netherlands (150) and Italy (64). The high numbers of France are however artificial and originate from communication towards the public, which has not been as pronounced in other European countries. Genetic analyses suggest multiple introductions of O. nungara in Europe. Combination of morphological and molecular species identification revealed the presence of Obama anthropophila being the first record of this species outside its native range in Brazil. Our results further support the established status of these species in Europe and highlight the importance of citizen scientists in invasive species research.
Mode protégé
Authors: Kittler Friedrich 
Published: January 2025

Sommes-nous encore maîtres de nos machines d’écriture ? Que se joue-t-il derrière la distinction entre le hardware et le software ? Dans les deux conférences Le logiciel n’existe pas (1991) et Mode protégé (1993), publiées ici pour la première fois en français, un des pères fondateurs de la théorie des médias allemande Friedrich Kittler (1943-2011), interroge la mainmise de l’industrie du logiciel sur nos usages des ordinateurs et nous invite à une stimulante relecture du matérialisme.
L’Art contre le peuple ? Sociohistoire d’une rupture : l’exemple du théâtre public en France depuis 1945
Authors: Glas Marjorie 
Published: January 2025

Cet article traite de l’évolution de la croyance dans le rôle social attribué au théâtre entre 1945 et aujourd’hui. L’intervention publique en matière théâtrale s’est historiquement fondée sur deux antiennes : la défense de la liberté de création et la vocation émancipatrice du théâtre. L’histoire du théâtre public recoupe celle de l’articulation de ces deux piliers, s’articulant dans une tension constante entre souci apporté à l’élargissement des publics et innovation esthétique. Le système de croyance qui fonde le théâtre public a ainsi évolué au gré des contextes politiques, du profil socioprofessionnel des acteurs qui structurent le champ, de son institutionnalisation, de son degré de professionnalisation, de la composition du public comme de l’évolution plus générale du champ intellectuel. Cet article retrace cette évolution de manière chronologique.
Acute Stroke Management and Outcome: An Experience from One Private Tertiary Care Center in Eastern India
Authors: Chakraborty Debabrata , Biswas Devarati , Puri Sakshi , Malik Abdul , Eqbal Shagufta , Aleena Insha , Ghosh Ritwika , Dey Sadanand , Sen Priyanjita , Paul Sucharita 
Published: January 2025

Abstract

Background:
Stroke is already an epidemic, and the awareness about stroke, prevalence of risk factors, presentations, response to treatment, and outcome are variable in different parts of a country. We aimed to study the details of acute stroke patients who presented to a tertiary care private hospital in eastern India. We wanted to know how the patient’s family members, as well as private doctors in the community, responded to the acute stroke.

Methodology:
In this prospective and retrospective study for 2 years, from September 2021 to August 2023, we included patients over 18 years of age who presented with acute stroke symptoms within 24 h and were admitted to our hospital. In relation to an acute stroke, we noted patient demographics, clinical, radiological, and hematological details, treatment, and outcome (in hospital and after 3 months).

Results:
We included 366 patients and found that 74% were hypertensives and 50% were diabetics. We thrombolyzed 24 patients and performed mechanical thrombectomy on eight of them. In a significant number of cases, patients arrived late (only 45 out of 366 were candidates for acute stroke intervention), and attendants were not immediately ready with their consent for 15 of these 45 patients.

Conclusion:
We urgently need more public awareness programs to educate everyone about the “acute stroke pathway” and help them confidently accept the benefits and drawbacks of acute stroke intervention. We need to institute more stroke prevention clinics at the earliest to address the modifiable risk factors of stroke.