bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laughter as Natural Piety: John Dewey, Humor, and the Religious
Authors: Weidenbaum Jonathan 
Published: August 2023

Abstract
One topic frequently explored in the philosophy of humor is the relationship of comedy and laughter with other facets of human existence—including theological insight and religious experience. The aim of this essay is to employ the mature thought of John Dewey not only to illuminate the nature of humor, but also to discern the deep source and connection between the spiritually exalting and the funny from a naturalistic perspective. While a number of passages on comedy and humor from Dewey’s later work are addressed, mostly from Art as Experience, they are synthesized with other ideas from this same text along with a few quotes from John Morreall. The focus is then shifted toward the central themes of A Common Faith, Dewey’s proposal for a de-supernaturalized form of the religious life. It is suggested that the humorous and the religious, understood through Dewey’s refined account of experience, disclose a few very important things about our place within the cosmos as a whole—that greatest of contexts in and through which laughter and the spiritual alike acquire their significance. This Deweyan vision is further clarified by way of comparison with Peter Berger’s theological reflections on humor. The controversies over sin and the place of tragedy in Dewey’s religious naturalism are briefly discussed in the conclusion.
Quantifying Laughter in International Research
Authors: James Christine A. 
Published: August 2023

Abstract
Historical theories of humor rely on a classic distinction in philosophy, the distinction between reason and emotion. Such a distinction lends itself to qualitative rather than quantitative research. In the last 40 years, quantitative scholarship on laughter and comedy has become very popular, and often includes international and indigenous examples of laughter as a healing or teaching tool. This paper addresses the historical research on laughter and mockery, then shows the broad range of quantitative studies that have provided important data on the usefulness of humor in teaching and in memorization of material. While there are a variety of items that one might laugh at, there are also certain commonalities that transcend social groups.
Vowel-internal cues to vowel quality and prominence in speech perception
Authors: Steffman Jeremy 
Published: August 2023

Abstract
This study examines how variation in F0 and intensity impacts the perception of American English vowels. Both properties vary intrinsically as a function of vowel features in the speech production literature, raising the question of the perceptual impact of each. In addition to considering listeners’ interpretation of either cue as an intrinsic property of the vowel, the possible prominence-marking function of each is considered. Two patterns of prominence strengthening in vowels, sonority expansion and hyperarticulation, are tested in light of recent findings that contextual prominence impacts vowel perception in line with these effects (i.e. a prominent vowel is expected by listeners to be realized as if it had undergone prominence strengthening). Across four vowel contrasts with different height and frontness features, listeners categorized phonetic continua with variation in formants, F0 and intensity. Results show that variation in level F0 height is interpreted as an intrinsic cue by listeners. Higher F0 cues a higher vowel, following intrinsic F0 effects in the production literature. In comparison, intensity is interpreted as a prominence-lending cue, for which effect directionality is dependent on vowel height. Higher intensity high vowels undergo perceptual re-calibration in line with (acoustic) hyperarticulation, whereas higher intensity non-high vowels undergo perceptual re-calibration in line with sonority expansion.
A corpus-assisted analysis of indexical signs for (im)politeness in Japanese apology-like behaviour
Authors: Diegoli Eugenia 
Published: August 2023

Abstract
This study provides a corpus-assisted pragmatic investigation of three Japanese expressions: the adverb chotto ‘a little’, the verb-ending form -te shimau, conveying (formulaic) regret, and the conditional clause with -tara. These are deictic forms I refer to as indexical signs for (im)politeness because they can, under certain circumstances, trigger evaluations in terms of (im)politeness, potentially favouring an indirect interpretation of the utterance. They are investigated in co-occurrence with apology-like behaviour based on the assumption that, in this context, interactants are more likely to exploit linguistic strategies for conveying additional layers of pragmatic meaning. The main findings point to a wide range of possible interactional meanings the selected forms can acquire in naturally occurring data, from affecting the illocutionary force of the utterance, to conventionally matching interactants’ expectations, to conveying a potentially face-threatening act. These results support the assumption that seemingly polite speech acts will not necessarily be doing polite work (or not only) and highlight the relevance of the interactional context for retrieving communicative meanings.
Gold nanoparticle-based strategies against SARS-CoV-2: A review
Authors: Rasmi Yousef , Kırboğa Kevser K. , Khan Johra , Gupta Ena , Mostafa Fadia , Yallapu Murali M. , Pilaquinga Fernanda 
Published: August 2023

AbstractThe COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 has been an immense threat to global public health and has also had a negative socioeconomic impact worldwide. However, although the pandemic is now under control, it has demonstrated that society is unprepared to use analysis methods that are applicable to various types of viruses nor apply new therapies to prevent infections, considering the extensive time needed for vaccine development. The use of nanomaterial-based diagnostics and therapeutics can provide essential strategies for both virus detection and treatment. Gold nanoparticles (AuNPs) are the nanomaterials most commonly used to enhance virus detection because of their bioconjugation, high plasmon resonance, and excellent electrical, optical, and catalytic properties. The present review outlines the recent advances reported in the literature regarding using AuNPs for their antiviral activities with respiratory viruses, analysis techniques such as AuNP-assisted polymerase chain reaction, biosensors (electrochemical, piezoelectric, and optical), lateral flow analysis, nucleic acid assays, and gene and vaccine therapy. Finally, as a potential antiviral treatment, this review providesin vitroandin vivotoxicity results of AuNPs for respiratory viruses, as well as those related to their toxicity in humans, to evaluate their use as a future antiviral treatment.
Impacts and potential mechanisms of fine particulate matter (PM2.5) on male testosterone biosynthesis disruption
Authors: Zheng Shaokai , Zhao Nannan , Lin Xiaojun , Qiu Lianglin 
Published: August 2023

Abstract
Exposure to PM2.5 is the most significant air pollutant for health risk. The testosterone level in male is vulnerable to environmental toxicants. In the past, researchers focused more attention on the impacts of PM2.5 on respiratory system, cardiovascular system, and nervous system, and few researchers focused attention on the reproductive system. Recent studies have reported that PM2.5 involved in male testosterone biosynthesis disruption, which is closely associated with male reproductive health. However, the underlying mechanisms by which PM2.5 causes testosterone biosynthesis disruption are still not clear. To better understand its potential mechanisms, we based on the existing scientific publications to critically and comprehensively reviewed the role and potential mechanisms of PM2.5 that are participated in testosterone biosynthesis in male. In this review, we summarized the potential mechanisms of PM2.5 triggering the change of testosterone level in male, which involve in oxidative stress, inflammatory response, ferroptosis, pyroptosis, autophagy and mitophagy, microRNAs (miRNAs), endoplasmic reticulum (ER) stress, and N6-methyladenosine (m6A) modification. It will provide new suggestions and ideas for prevention and treatment of testosterone biosynthesis disruption caused by PM2.5 for future research.
Interoperability Between Mobile Money Agents and Choice of Network Operators: The Case of Tanzania
Authors: Grzybowski Lukasz , Lindlacher Valentin , Mothobi Onkokame 
Published: August 2023

Abstract
In this paper, we investigate the effects of non-exclusive agreements between networks of mobile money agents on mobile network operator choices, using survey data from Tanzania conducted in 2017. By combining survey responses with geo-location data and information on agent proximity, we employ discrete choice models to analyze consumers’ decisions in subscribing to mobile network operators and their corresponding mobile money providers. Our findings highlight the significant influence of the distance to mobile money agents on consumers’ subscription choices. To explore the impact of interoperability (non-exclusivity) at the mobile money agent level, where consumers can use the nearest agent from any mobile money provider, we assess its effects on market shares of mobile network operators. Our results indicate that interoperability at the agent level has only a minor impact on market shares. Smaller operators experience marginal gains as their consumers can now utilize agents of larger providers, which are often closer in proximity. In conclusion, we find that interoperability at the agent level does not considerably alter the market structure in the context Tanzania during the period under consideration.
Exploring nanotechnology-based approaches using miRNAs to treat neurodegenerative disorders
Authors: Mushtaq Gohar , Hasani Ibrahim W. , Al-Daoud Fouad , Unnisa Aziz , Mutair Yahya A. , Kabba Samer , Alkanash Yaser 
Published: August 2023

Abstract
MicroRNAs (miRNAs) are small non-coding molecules that play a pivotal part in brain development and the processes of establishment and maintenance of dendrites and neurite outgrowth by modulating gene expression. Dysregulation of miRNAs has been linked with neurological disorders. Exogenous miRNAs are unstable in the plasma due to degradation by nucleases; hence, choosing a harmless and effective delivery mode is crucial in the quest for miRNA-based therapeutics to treat neurological disorders. This review aims to shed light on the emerging role of nanotechnology-based approaches using miRNAs to treat neurodegenerative disorders. Nanotechnology encompasses a broad spectrum of applications, one of which is its role in developing nanoscale drug delivery systems. Nanotechnology-based drug delivery systems have attracted the attention of researchers due to the superiority of this mode over conventional treatment systems in terms of their favorable attributes such as bio-compatibility, bio-degradability, extremely small size, and the ability to cross the blood-brain barrier. This review explores nanotechnology-based approaches using miRNAs highlighting the use of viral vectors as well as non-viral vectors (such as exosomes, liposome nanoparticles, gold and magnetic nanoparticles, dendrimer-based nanoparticles, polymeric nanoparticles) to treat neurodegenerative disorders.
Within- and between-subject biological variation of hemostasis parameters in a study of 26 healthy individuals
Authors: Zengi Oguzhan , Uçar Kamil Taha 
Published: August 2023

Abstract

Objectives
The study aimed to estimate the biological variation (BV) of routine coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen, in a healthy population to enhance the accuracy of laboratory results and improve diagnosis and treatment decisions.

Methods
The study included 26 healthy volunteers over 10 weeks; samples were collected weekly. The within-subject BV (CVI) and between-subject BV (CVG) were calculated for each parameter, and the index of individuality (II) and reference change values (RCV) were determined. All tests were performed in duplicate on the Roche Cobas T-711 coagulation analyzer.

Results
Fibrinogen exhibited the highest BV, with a CVI of 11 % and CVG of 17.4 %. The aPTT test had a CVI of 5.8 %, a CVG of 8.4 %, and an II of 0.91. The PT test had a CVI of 3.2 %, a CVG of 5.8 %, and an II of 0.73. The RCV values ranged from −7.5 to 8.1 for PT, −12.7 to 14.6 for aPTT, and −22.7 to 29.4 for fibrinogen.

Conclusions
The study underscores the significant biological variation in routine hemostasis parameters, such as PT, APTT, and fibrinogen, which impacts clinical diagnoses and treatment decisions. Despite certain limitations, the findings offer valuable insights for clinicians and suggest that future research should include more parameters for a comprehensive understanding of biological variations in hemostasis testing.
Impact of temperature asymmetry and small fraction of static positive ions on the relaxed states of a relativistic hot pair plasma
Authors: Shazad Usman , Iqbal M. 
Published: August 2023

Abstract
The relaxed state of a magnetized relativistic hot plasma composed of inertial electrons and positrons having different relativistic temperatures and a fraction of static positive ions is studied. From the steady-state solutions of vortex dynamics equations and the relation for current density, a non-force-free triple Beltrami (TB) relaxed state equation is derived. The TB state is characterized by three scale parameters that consequently provide three different self-organized structures. The analysis of the relaxed state shows that for specific values of generalized helicities, the disparity in relativistic temperature and the existence of a small fraction of static positive ions in pair plasma can transform the nature of scale parameters. Moreover, an analytical solution of the TB state for an axisymmetric cylindrical geometry with an internal conductor configuration demonstrates that due to asymmetries of temperature and density of plasma species, diamagnetic structures can transform into paramagnetic ones and vice versa. The present study will improve our understanding of pair plasmas in trap-based plasma confinement experiments and astrophysical environments.
THERAPEUTIC DWELLING: MENTAL REHABILITATION AND HEALING CENTER WITH BIOPHILIC DESIGN CONCEPT IN WEST JAKARTA
Authors: Dinisara Cyntha 
Published: August 2023

Mental health is one of the most important issues in the world, including Indonesia. Indonesia is the second-ranked country with the highest total cases of mental disorders in Southeast Asia, which reached 9,162,886 (Estimates Global Health, 2017). According to Asia's Least and Most Stressful Cities (2017), the city of Jakarta is ranked 6th as the most stressful city in Indonesia. This mental health problem is triggered by a fast-paced lifestyle which makes it difficult for the people of Jakarta to adapt to one another so that people feel stressed or depressed. Unfortunately, society's paradigm of mental health disorders creates a stigma that can hinder the healing and recovery of sufferers. From a psychological point of view, environmental factors play an important role in the healing process for people with mental disorders. This is commonly referred to as a healing environment which is carried out by managing the relationship between nature, humans, and buildings that can support healing. The purpose of writing this design report is to plan a Mental Rehabilitation and Healing Center with a Biophilic Architecture approach in the City of Jakarta which is capable of providing therapy for sufferers of mental disorders with details including (1) planning and designing a Mental Rehabilitation and Healing Center that can accommodate therapy activities and healing with the Healing Environment method; (2) planning and designing a Mental Rehabilitation and Healing Center with a Biophilic Architecture Approach in the City of Jakarta. The method of discussion in this report uses descriptive methods, with factual data collection through literature studies, observational studies, analysis, and conclusions.
Key Word: Mental Rehabilitation Center in West Jakarta City, Biophilic Architecture.
Exhibition, Marketplace, and Handicraft Development Building in Jepara Regency with Neo- Vernacular Approach
Authors: Dzikrillah Khirza Faiz 
Published: August 2023

Jepara is known as the city of woodcarving. This reputation is attributed to the success of Jepara's carved furniture products in entering the international and global markets. In addition to woodcarving crafts, Jepara also produces various other crafts. The types of crafts in Jepara are diverse, including pottery, calligraphy, furniture, metalwork, sculptures, rattan weaving, batik, and woven textiles. These various crafts are concentrated in different areas within Jepara Regency. However, in its development, the number of craft practitioners in Jepara has decreased due to the development of several industrial areas in the regency, leading people to prefer working as factory employees rather than craftsmen. Therefore, efforts need to be made to preserve the crafts in Jepara as cultural heritage and potential for improving the community's economy in the creative industry sector. In this regard, the proposed solution is to establish an Exhibition, Marketplace, and Handicraft Development Building to preserve the crafts in Jepara as cultural heritage and economic potential in the creative industry sector.
The Exhibition, Marketplace, and Handicraft Development Building can serve as educational facilities
and economic activities related to crafts in Jepara Regency
Emodin improves glucose metabolism and ovarian function in PCOS mice via the HMGB1/TLR4/NF-κB molecular pathway
Authors: Otoo Antonia , Czika Armin , Lamptey Jones , Yang Jun-Pu , Feng Qian , Wang Mei-Jiao , Wang Ying-Xiong , Ding Yu-Bin 
Published: August 2023

In brief
Obese PCOS mice display metabolic and endocrine disorders that manifest as abnormal metabolism of glucose and dysfunctions in the reproductive system. This study demonstrates that emodin alleviates most of these conditions possibly via the HMGB1/TLR4/NF-kB pathway.

Abstract
PCOS is a reproductive disorder with an unclear etiology. It affects 5–10% of women worldwide and is largely associated with impaired glucose metabolism and obesity. HMGB1 is a nuclear protein associated with impaired glucose metabolism and PCOS. We sought to investigate the potential therapeutic effects of emodin on glucose metabolism and ovarian functions in PCOS mice via the HMGB1 molecular pathway. A high-fat diet (HFD) and dehydroepiandrosterone (DHEA)- induced PCOS mouse model comprising four experimental groups was established: control, PCOS, PCOS plus emodin, and PCOS plus vehicle groups. Emodin administration attenuated obesity, elevated fasting glucose levels, impaired glucose tolerance, and insulin resistance, and improved the polycystic ovarian morphology of PCOS mice. Additionally, it lowered elevated serum HMGB1, LH, and testosterone levels in PCOS mice. Elevated ovarian protein and mRNA levels of HMGB1 and TLR4 in PCOS mice were also lowered following emodin treatment. Furthermore, emodin lowered high NF-ĸB/65 protein levels in the ovaries of PCOS mice. Immunohistochemical staining of the ovaries revealed strong HMGB1, TLR4, and AR expressions in PCOS mice, which were lowered by emodin treatment. Moreover, emodin significantly increased GLUT4, IRS2, and INSR levels that were lowered by PCOS. Overall, our study showed that emodin alleviated the impaired glucose metabolism and improved ovarian function in PCOS mice, possibly via the HMGB1/TLR4/NF-ĸB signaling pathway. Thus, emodin could be considered a potential therapeutic agent in the management of PCOS.
Back to Basics: Reporting National Drug Codes
Authors:   American Academy of Pediatrics
Published: August 2023

When reporting vaccines and medications supplied in a physician practice, it is typically necessary to report an 11-digit National Drug Code (NDC). This article reviews how to appropriately report NDCs, including the following key points:
Selection of the appropriate NDC Conversion of a 10-digit NDC to include the required 11 digits Selecting the NDC unit of measure Entering NDC information into the claim
HUBUNGAN KEPRIBADIAN BIG FIVE DENGAN PERILAKU BERKENDARA BERISIKO PENGENDARA MOTOR SISWA SMA
Authors: Fatmawiyati Jati , Al Farizi Reza Hanif , Chusniyah Tutut 
Published: August 2023

Abstract: This research aims to determine the role of personality on risky driving behavior of high school students. This study is important to do, because the attitude of the motorbike rider causes a lot of traffic accidents. Data collection using the risky driving behavior scale from Iversen (2004) which has been adapted into Indonesian by Alfazi (2018) consists of 24 items. All items are valid with a validity value of 0.309–0.778 and a reliability of 0.688. Personality instrument uses Extra-Short Big Five Iventory-2 by Soto and John (2017) which has been adapted by Tresnawaty and Izdihar (2020) which consists of 15 items. The validity shows a value of 0.318–0.47 with a reliability of 0.611. The sample is 119 students of SMAN 1 Ngunut Tulungagung, grades 10-12 who rode motorbikes and distributed questionnaires using google form. Data analysis using multiple regression, previously tested for normality, linearity, and heteroscedasticity. The results of hypothesis testing show that personality is a predictor of risky driving behavior. However, when viewed pertrait, only agreeableness and neuroticism significantly affect risky driving behavior. Meanwhile, openness to experience, conscientiousness and extraversion are not significant.
Abstrak: Tujuan pelaksanaan penelitiaan ini yakni untuk mengetahui peran kepribadian terhadap perilaku berkendara yang beresiko siswa SMAN. Penelitian ini penting untuk dilakukan, karena sikap pengemudi motor mengakibatkan banyak terjadi kecelakaan lalu lintas. Pengambilan data menggunakan skala risk driving behavior dari Iversen (2004) yang telah diadaptasi kedalam bahhasa Indonesia oleh Alfazi (2018) terdiri dari 24 aitem. Semua aitem valid dengan nilai validitas 0.309–0.778 dan reliabilitas 0.688. Instrumen kepribadian menggunakan Extra-Short Big Five Iventory-2 oleh Soto dan John (2017) yang telah diadaptasi oleh Tresnawaty dan Izdihar (2020) yang terdiri dari 15 aitem. Uji validitas menunjukkan nilai 0.318–0.47 dengan reliabilitas sebasar 0.611. Sampel 119 siswa SMAN 1 Ngunut Tulungagung, kelas 10-12 yang mengendarai sepeda motor dan penyebaran kuesioner menggunakan google form. Analisis data menggunakan Spearman Brown, karena saat dilakukan uji normalitas data tidak normasl. Hasil uji hipotesis menunjukkan tingkat signifikansi dibawah 0.05 (0.04<0.05), maka ada hubungan positif antara perilaku berkendara beresiko dengan neuroticism dan agreeableness, sedangkan hubungan opennes to experience, conscientiousness dan extraversion dengan perilaku berkendara beresiko tidak signifikan