bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification
Authors: Gao Juan , Su Gang , Chen Wei , Wu Qionghui , Liu Junxi , Liu Jifei , Chai Miao , Dong Ying , Wang He , Chen Lixia , Zhang Zhenchang , Wang Manxia 
Published: June 2023

AbstractLigustilide, a natural phthalide mainly derived from chuanxiong rhizomes and Angelica Sinensis roots, possesses anti‐inflammatory activity, particularly in the context of the nervous system. However, its application is limited because of its unstable chemical properties. To overcome this limitation, ligusticum cycloprolactam (LIGc) was synthesized through structural modification of ligustilide. In this study, we combined network pharmacological methods with experimental verification to investigate the anti‐neuroinflammatory effects and mechanisms of ligustilide and LIGc. Based on our network pharmacology analysis, we identified four key targets of ligustilide involved in exerting an anti‐inflammatory effect, with the nuclear factor (NF)‐κB signal pathway suggested as the main signalling pathway. To verify these results, we examined the expression of inflammatory cytokines and inflammation‐related proteins, analysed the phosphorylation level of NF‐κB, inhibitor of κBα (IκBα) and inhibitor of κB kinase α and β (IKKα+β), and evaluated the effect of BV2 cell‐conditioned medium on HT22 cells in vitro. Our results, demonstrate for the first time that LIGc can downregulate the activation of the NF‐κB signal pathway in BV2 cells induced by lipopolysaccharide, suppress the production of inflammatory cytokines and reduce nerve injury in HT22 cells mediated by BV2 cells. These findings suggest that LIGc inhibits the neuroinflammatory response mediated by BV2 cells, providing strong scientific support for the development of anti‐inflammatory drugs based on natural ligustilide or its derivatives. However, there are some limitations to our current study. In the future, further experiments using in vivo models may provide additional evidence to support our findings.
Local House Price Effects of Internal Migration in Queensland: Australia's Interstate Migration Capital
Authors: Erol Isil , Unal Umut 
Published: June 2023

AbstractWe examine the causal impact of internal migration on housing prices across 82 Statistical Areas Level 3 regions in Queensland, Australia from 2014–2019. The primary findings are: (i) an annual increase in the inflow of migrants equal to 1 per cent of a region's initial population leads to a 0.6 to 0.7 per cent annual increase in Queensland's house prices across different empirical specifications; (ii) this effect differs between the Greater Brisbane metropolitan area and Rest of State areas; (iii) migration from New South Wales fails to produce a significant influence on house price growth in Queensland.
Does Day 3 embryo status matter to reproductive outcomes of single blastocyst transfer cycles? A cohort study
Authors: Qiu Jiaxin , Du Tong , Guo Haiyan , Mol Ben W. , Lin Jiaying , Zhao Dong , Wang Yun , Kuang Yanping , Li Wentao 
Published: June 2023

AbstractObjectiveTo investigate whether Day 3 (D3) embryo status matter to reproductive outcomes of blastocyst transfer cycles.DesignRetrospective cohort study.SettingAssisted Reproduction Department of Shanghai Ninth People's Hospital, Shanghai, China.PopulationA total of 6906 vitrified–thawed single blastocyst transfer cycles in 6502 women were included.MethodsGeneralised estimated equation regression models were used to calculate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the associations between embryo status and pregnancy outcomes.Main outcome measuresBiochemical pregnancy, miscarriage, live birth.ResultsHigh‐quality blastocysts derived from poor‐grade D3 embryos had comparable pregnancy outcomes to those derived from high‐grade D3 embryos (40.0% versus 43.2%, aOR 1.00, 95% CI 0.85–1.17 for live birth rate; 8.3% versus 9.5%, aOR 0.82, 95% CI 0.63–1.07 for miscarriage rate). Cycles with low D3 cell number (five cells or fewer) had significantly higher miscarriage rate (9.2% versus 7.6%, aOR 1.33, 95% CI 1.02–1.75) compared with cycles with eight cells on D3.ConclusionsPoor‐quality cleavage embryos should be cultivated to the blastocyst stage because high‐quality blastocysts derived from poor‐grade D3 embryos had acceptable pregnancy outcomes. When the blastocyst grade is identical, choosing embryos with higher D3 cell number (eight or more cells) for transfer could reduce the risk of early miscarriage.
Factors affecting continuous renal replacement therapy duration in critically ill patients: A retrospective study
Authors: Guo Litao , Hu Yandong , Zeng Qinjing , Yang Xinjuan 
Published: June 2023

AbstractIntroductionThis study aimed to analyze the factors affecting continuous renal replacement therapy (CRRT) duration in critically ill patients and provide a reference for clinical treatment.Material and MethodsWe divided patients into regional citrate anti‐coagulation (RCA) and low‐molecular‐weight‐heparin (LMWH) groups according to the anti‐coagulation method and collected the relevant data, to analyze the factors associated with CRRT time.ResultsCompared with the LMWH group, the RCA group had a longer mean treatment time (55.36 ± 22.57 vs. 37.65 ± 27.09 h, p < 0.001), lower transmembrane pressure, and lower filter pressure, regardless of vascular access site. Multivariable linear regression analysis showed a significant correlation between anti‐coagulation patterns, filter pressure at CRRT discontinuation, nurses' level of intensive care unit experience, pre‐machine fibrinogen level, and CRRT time.ConclusionAnti‐coagulation is the most important factor affecting CRRT duration. Filter pressure, nurses' level of intensive care unit experience, and fibrinogen level also affecting CRRT duration.
Immunogenicity of COVID‐19 vaccines in adult patients with autoimmune inflammatory rheumatic diseases: A systematic review and meta‐analysis
Authors: Al‐Haideri Maysoon , Mohammad Talar Ahmad Merza , Darvishzadehdeldari Shahram , Karbasi Zahra , Alimohammadi Mina , Faramarzi Fatemeh , Khorasani Sahar , Rasouli Ashkan , Tahmasebi Safa , Darvishi Mohammad , Akhavan‐Sigari Reza 
Published: June 2023

AbstractCOVID‐19 vaccines approved by the Food and Drug Administration have been studied mainly in healthy individuals and there is limited information on their immunogenicity in patients with autoimmune diseases. Therefore, the current systematic review and meta‐analysis study, aimed to comprehensively investigate the immunogenicity of these vaccines in patients with autoimmune inflammatory rheumatoid diseases (AIRDs). A comprehensive literature search was performed on various databases, including Google Scholar, PubMed, Web of Science, EMBASE, and Cochrane Library, to select cohort and randomized clinical trial (RCT) studies up to January 2022. Also, the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses checklist protocol and the I2 statistic were used for quality assessment and heterogeneity tests of the selected studies. Fixed and random‐effects models were estimated based on the heterogeneity tests, and pooled data were determined as the ratio of mean (ROM) with a 95% confidence interval (CI). As a result, we found that vaccines can cause favorable immunogenicity and antibody response in vaccinated AIRD patients; however, older age and the concomitant consumption of conventional synthetic disease‐modifying anti‐rheumatic drugs (csDMARDs) and biologic DMARDs (bDMARDs) could significantly reduce the vaccine immunogenicity. Consequently, our findings revealed significant humoral responses (seropositive) in AIRD patients following the administration of COVID‐19 vaccines.
A low‐cost, long‐running, open‐source stereo camera for tracking aquatic species and their behaviours
Authors: Dunkley Katie , Dunkley Andrew , Drewnicki James , Keith Inti , Herbert‐Read James E. 
Published: June 2023

Abstract

Ecologists are now widely utilising video data to quantify the behaviours and interactions of animals in the wild. This process can be facilitated by collecting videos in stereo, which can provide information about animals' positions, movements and behaviours in three‐dimensions (3D). However, there are no published designs that can collect underwater 3D stereo data at high spatial and temporal resolutions for extended periods (days).

Here, we present complete hardware and software solutions for a long‐running, open‐source, underwater stereo camera rig, costing £1337. This stereo camera can continuously record aquatic species and their behaviours/interactions in high resolution (1080 p and 30 fps) and in 3D, over multiple days.

We provide full design guides for the cameras and a travel‐friendly rig, and include guidance and open‐source code for calibrating the cameras in space and time. We also show how these cameras could be used to track animals' body parts and positions, and how their size, posture and behaviour can be inferred.

This stereo camera will facilitate the collection of high‐resolution ecological and behavioural data, such as affiliative, agonistic or trophic interactions between species, which can inform us about the health and structure of ecosystems. These data will assist ecologists and conservationists in monitoring and understanding the impacts of current environmental pressures on ecosystem functioning.
The sin of words: Censorship and self‐censorship in China during the Qing dynasty (1644–1911)
Authors: Li Peiyuan 
Published: June 2023

AbstractThis study examines the impact of a large‐scale censorship campaign in Qing China (1644–1911) on intellectuals' writings. Using a Difference‐in‐Difference approach and analysing 23,000 poems, the study reveals a significant decrease in the frequency of censored words in poems written by censored intellectuals. There was no room to circumvent censorship by adopting homophones, split words, and variant characters. The machine learning analyses uncover some indication that the censorship campaign influenced intellectuals' writing styles, with intellectuals shifting away from the censored poetry. The campaign created intense political pressures, leading to self‐censorship, but its long‐term impact on word choices was minimal.
What makes a “good” forensic anthropologist?
Authors: Marten Meredith G. , Winburn Allysha P. , Burgen Benjamin R. , Seymour Spencer K. , Walkup Taylor 
Published: June 2023

AbstractForensic anthropology has recently and publicly grappled with fundamental disciplinary issues—including estimating population affinity, the pursuit of objectivity, and the role of bias in medicolegal contexts—all of which has left the subdiscipline in a state of seeming fracture, with many practitioners worried about its future. Given these concerns, we wondered to what degree polarization exists, if at all, and along what lines. Using the method of cultural consensus analysis, we asked forensic anthropologists: What makes a “good” forensic anthropologist? Our findings suggest that contrary to widespread concern, broad agreement (consensus) exists over the training, experiences, perspectives, and practices forensic anthropologists (n = 103) identified as important for being “good” at what they do. A few points of disagreement emerged—particularly over the issue of neutrality—which dominated the narrative feedback we received. The fault lines of this debate primarily fell along generational lines, with those having earned their degrees earlier believing more strongly in neutrality. This pattern largely maps onto broader (and somewhat routine) disciplinary debates and trends away from positivism, with younger anthropologists more focused on the larger goal of “decolonizing US anthropology” and attending to the antiracist work that figures prominently in anthropology today.
The effects of menstrual cycle phases on immune function and inflammation at rest and after acute exercise: A systematic review and meta‐analysis
Authors: Notbohm H. L. , Moser F. , Goh J. , Feuerbacher J. F. , Bloch W. , Schumann M. 
Published: June 2023

AbstractThe immune system plays an important role in mediating exercise responses and adaptations. However, whether fluctuating hormone concentrations across the menstrual cycle may impact these processes remains unknown. The aim of this systematic review with meta‐analysis was to compare baseline concentrations as well as exercise‐induced changes in immune and inflammatory parameters between menstrual cycle phases. A systematic literature search was conducted according to the PRISMA guidelines using Pubmed/MEDLINE, ISI Web of Science, and SPORTDiscus. Of the 159 studies included in the qualitative synthesis, 110 studies were used for meta‐analysis. Due to the designs of the included studies, only the follicular and luteal phase could be compared. The estimated standardized mean differences based on the random‐effects model revealed higher numbers of leukocytes (−0.48 [−0.73; −0.23], p < 0.001), monocytes (−0.73 [−1.37; −0.10], p = 0.023), granulocytes (−0.85 [−0.1.48; −0.21], p = 0.009), neutrophils (−0.32 [−0.52; −0.12], p = 0.001), and leptin concentrations (−0.37 [−0.5; −0.23], p = 0.003) in the luteal compared to the follicular phase at rest. Other parameters (adaptive immune cells, cytokines, chemokines, and cell adhesion molecules) showed no systematic baseline differences. Seventeen studies investigated the exercise‐induced response of these parameters, providing some indications for a higher pro‐inflammatory response in the luteal phase. In conclusion, parameters of innate immunity showed cycle‐dependent regulation at rest, while little is known on the exercise responses. Due to a large heterogeneity and a lack of cycle phase standardization among the included studies, future research should focus on comparing at least three distinct hormonal profiles to derive more specific recommendations for exercise prescription.
Patterns of suboptimal antipsychotic use and misuse in Australia: What can routinely collected data tell us?
Authors: Brett Jonathan , Gillies Malcolm B. , Buckley Nicholas A. , Pearson Sallie‐Anne , Zoega Helga 
Published: June 2023

AimsThere are increasing concerns about harms related to suboptimal antipsychotic use. Here we describe recent population‐based trends in antipsychotic use and harms in Australia and identify population groups exhibiting patterns of use likely to contribute to these harms.MethodsUsing population‐based data from the Australian Pharmaceutical Benefits Scheme (2015‐2020), poisoning calls to the New South Wales (NSW) Poisons Information Centre (2015‐2020) and poisoning deaths in all coronial records (2005‐2018) in Australia, we measured trends in the prevalence of antipsychotic use and related deaths and poisonings. We applied latent class analyses to identify patterns of antipsychotic use that may contribute to harms.ResultsQuetiapine and olanzapine had the highest prevalence of use between 2015 and 2020. Noteworthy trends included increases of 9.1% and 30.8% in quetiapine use and poisonings, while olanzapine use decreased by 4.5% but poisonings increased by 32.7%. Quetiapine and olanzapine poisonings and related deaths had the highest rates of co‐ingestion of opioids, benzodiazepines and pregabalin compared to other antipsychotics. We identified six distinct population groups using antipsychotics: (i) ongoing high‐dose use with sedatives (8%), (ii) ongoing use (42%), (iii) ongoing use with analgesics and sedatives (11%), (iv) long‐term low‐dose use (9%), (v) sporadic use (20%) and (vi) sporadic use with analgesics (10%).ConclusionOngoing potentially suboptimal antipsychotic use and associated harms highlight the need to monitor such patterns of use, for example through prescription monitoring systems.
Radiographic outcomes of ridge reconstruction with autogenous bone block versus collagenated xenogeneic bone block: A randomized clinical trial
Authors: Romito Giuseppe Alexandre , Soares Herbert Horiuti , do Amaral Guilherme Castro Lima Silva , Fonseca Marcelo Augusto , Sapata Vitor Marques , Conde Marina Clemente , Hammerle Christoph Hans Franz , Schwarz Frank , Villar Cristina Cunha 
Published: June 2023

AbstractAimTo compare, at different levels from the alveolar crest, the radiographic outcomes of equine‐derived collagenated xenogeneic bone blocks (CXBB) and autogenous bone blocks (ABB) used for lateral alveolar ridge augmentation.Materials and MethodsSixty‐four patients with tooth gaps in atrophic alveolar ridges with ≤4 mm were randomly assigned to lateral augmentation using CXBB or ABB. The lateral bone thickness (LBT) was measured 2, 4, 6, 8, and 10 mm below the alveolar crest using CBCT scans obtained before augmentation surgery and at 30 weeks, prior to implant placement. Statistical analysis was performed using Shapiro–Wilk, Fisher's exact, Mann–Whitney, and Wilcoxon signed‐rank tests.ResultsBoth CXBB and ABB resulted in significant total and buccal LBT gains at 2, 4, 6, 8, and 10 mm. LBT gains were similar between CXBB‐ and ABB‐augmented sites, except for greater buccal LBT gains at 8 mm at CXBB‐augmented sites. While ABB‐augmented sites gained vertical bone height, CXBB‐treated sites suffered vertical bone loss (CXBB: −0.16 mm; ABB: 0.38 mm, p < .0009).ConclusionsCXBB and ABB were both associated with significant and similar LBT gains at 30 weeks.
HOXD‐AS2‐STAT3 feedback loop attenuates sensitivity to temozolomide in glioblastoma
Authors: Zhang Zuo‐Xin , Ren Peng , Cao Yong‐Yong , Wang Ting‐Ting , Huang Guo‐Hao , Li Yao , Zhou Shuo , Yang Wei , Yang Lin , Liu Guo‐Long , Xiang Yan , Pei Yu‐Chun , Chen Qiu‐Zi , Chen Ju‐Xiang , Lv Sheng‐Qing 
Published: June 2023

AbstractAimsGlioblastoma multiforme (GBM) is the deadliest glioma and its resistance to temozolomide (TMZ) remains intractable. Long non‐coding RNAs (lncRNAs) play crucial roles in that and this study aimed to investigate underlying mechanism of HOXD‐AS2‐affected temozolomide sensitivity in glioblastoma.MethodsWe analyzed and validated the aberrant HOXD‐AS2 expression in glioma specimens. Then we explored the function of HOXD‐AS2 in vivo and in vitro and a clinical case was also reviewed to examine our findings. We further performed mechanistic experiments to investigate the mechanism of HOXD‐AS2 in regulating TMZ sensitivity.ResultsElevated HOXD‐AS2 expression promoted progression and negatively correlated with prognosis of glioma; HOXD‐AS2 attenuated temozolomide sensitivity in vitro and in vivo; The clinical case also showed that lower HOXD‐AS2 sensitized glioblastoma to temozolomide; STAT3‐induced HOXD‐AS2 could interact with IGF2BP2 protein to form a complex and sequentially upregulate STAT3 signaling, thus forming a positive feedback loop regulating TMZ sensitivity in glioblastoma.ConclusionOur study elucidated the crucial role of the HOXD‐AS2‐STAT3 positive feedback loop in regulating TMZ sensitivity, suggesting that this could be provided as a potential therapeutic candidate of glioblastoma.
Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis
Authors: Gao Yuan , Liu Ning , Chen Juan , Zheng Ping , Niu Jianguo , Tang Shengsong , Peng Xiaodong , Wu Jing , Yu Jianqiang , Ma Lin 
Published: June 2023

AbstractBackgroundPosttraumatic epilepsy (PTE) is one of the most critical complications of traumatic brain injury (TBI), significantly increasing TBI patients' neuropsychiatric symptoms and mortality. The abnormal accumulation of glutamate caused by TBI and its secondary excitotoxicity are essential reasons for neural network reorganization and functional neural plasticity changes, contributing to the occurrence and development of PTE. Restoring glutamate balance in the early stage of TBI is expected to play a neuroprotective role and reduce the risk of PTE.AimsTo provide a neuropharmacological insight for drug development to prevent PTE based on regulating glutamate homeostasis.MethodsWe discussed how TBI affects glutamate homeostasis and its relationship with PTE. Furthermore, we also summarized the research progress of molecular pathways for regulating glutamate homeostasis after TBI and pharmacological studies aim to prevent PTE by restoring glutamate balance.ResultsTBI can lead to the accumulation of glutamate in the brain, which increases the risk of PTE. Targeting the molecular pathways affecting glutamate homeostasis helps restore normal glutamate levels and is neuroprotective.DiscussionTaking glutamate homeostasis regulation as a means for new drug development can avoid the side effects caused by direct inhibition of glutamate receptors, expecting to alleviate the diseases related to abnormal glutamate levels in the brain, such as PTE, Parkinson's disease, depression, and cognitive impairment.ConclusionIt is a promising strategy to regulate glutamate homeostasis through pharmacological methods after TBI, thereby decreasing nerve injury and preventing PTE.
Excitatory‐inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex
Authors: Zhang Tingting , Guo Bingqi , Zuo Zhentao , Long Xiaojing , Hu Shimin , Li Siran , Su Xin , Wang Yuping , Liu Chunyan 
Published: June 2023

AbstractAimsTranscranial focus ultrasound stimulation (tFUS) is a promising non‐invasive neuromodulation technology. This study aimed to evaluate the modulatory effects of tFUS on human motor cortex (M1) excitability and explore the mechanism of neurotransmitter‐related intracortical circuitry and plasticity.MethodsSingle pulse transcranial magnetic stimulation (TMS)‐eliciting motor‐evoked potentials (MEPs) were used to assessed M1 excitability in 10 subjects. Paired‐pulse TMS was used to measure the effects of tFUS on GABA‐ and glutamate‐related intracortical excitability and 1H‐MRS was used to assess the effects of repetitive tFUS on GABA and Glx (glutamine + glutamate) neurometabolic concentrations in the targeting region in nine subjects.ResultsThe etFUS significantly increased M1 excitability, decreased short interval intracortical inhibition (SICI) and long interval intracortical inhibition (LICI). The itFUS significantly suppressed M1 excitability, increased SICI, LICI, and decreased intracortical facilitation (ICF). Seven times of etFUS decreased the GABA concentration (6.32%), increased the Glx concentration (12.40%), and decreased the GABA/Glx ratio measured by MRS, while itFUS increased the GABA concentration (18.59%), decreased Glx concentration (0.35%), and significantly increased GABA/Glx ratio.ConclusionThe findings support that tFUS with different parameters can exert excitatory and inhibitory neuromodulatory effects on the human motor cortex. We provide novel insights that tFUS change cortical excitability and plasticity by regulating excitatory‐inhibition balance related to the GABAergic and glutamatergic receptor function and neurotransmitter metabolic level.
Officials' Foreign Experience and Firms' Exports: Evidence from China
Authors: Xu Yekun , Ma Guangyuan , Cui Lijuan 
Published: June 2023

AbstractThis study examines how the foreign experience of local officials affects firms' exports in China. Using a matched sample from 2000 to 2012, we found that the foreign experience of municipal Party secretaries had a significant impact on the promotion of firms' exports, especially for private firms. This positive impact was more pronounced when officials went abroad at a younger age, stayed abroad for a longer period, returned to China for a longer time, and had greater promotion incentives. We found that officials' foreign experience helped to mitigate the negative impact of institutional distance and provided firms with better access to export subsidies, both of which could promote exporting. There was also a complementary effect when officials and executives both had foreign experience. Overall, our study provides some insights into the economic outcomes of officials' foreign experience and sheds light on the export performance of Chinese firms.