bluuebunny/crossref_metadata_2025_split huggingface dataset:
The diagnostic value of serum insulin-like growth factor binding protein 7 in gastric cancer
Authors: Liu Can-Tong , Wu Fang-Cai , Zhuang Yi-Xuan , Huang Xin-Yi , Li Xin-Hao , Qu Qi-Qi , Peng Yu-Hui , Xu Yi-Wei , Chen Shu-Lin , Huang Xu-Chun 
Published: June 2023

Backgrounds
Early detection might help in reducing the burden and promoting the survival rate of gastric cancers. Herein, we tried to explore the diagnostic value of insulin-like growth factor binding protein 7 (IGFBP7) in gastric cancers.

Methods
In this study, we first analyzed the expression levels and prognostic value of IGFBP7 mRNA in gastric cancers from The Cancer Genome Atlas (TCGA) database. Then, we recruited 169 gastric cancer patients and 100 normal controls as training cohort, and 55 gastric cancer patients and 55 normal controls as independent validation cohort. Enzyme-linked immunosorbent assay was applied to test the serum levels of IGFBP7. The receiver operating characteristic curve (ROC) and the area under the curve (AUC) were applied to evaluation the diagnostic value.

Results
TCGA showed that IGFBP7 mRNA was dysregulated and associated with prognosis in gastric cancer patients. Then, we examined the expression of serum IGFBP7 and found that serum IGFBP7 expressed lower in gastric cancer patients than normal controls both in training and independent validation cohorts (p < 0.0001). In training cohort, with the cutoff value of 1.515 ng/ml, the AUC for distinguishing gastric cancer patients was 0.774 (95% CI [0.713–0.836]) with sensitivity of 36.7% (95% CI [29.5–44.5]) and specificity of 90.0% (95% CI [82.0–94.8]). As for early-stage EJA, the AUC was 0.773 (95% CI [0.701–0.845]) with the sensitivity of 33.3% (95% CI [14.4–58.8]). In independent validation cohort, with the same cutoff value, the AUC reached to 0.758 (95% CI [0.664–0.852]). Similarly, for early-stage gastric cancer diagnosis in the independent validation cohort, the AUC value was 0.778 (95% CI [0.673–0.882]).

Conclusions
This study indicated that serum IGFBP7 might act as a potential early diagnostic marker for gastric cancers.
Exploring forearm muscle coordination and training applications of various grip positions during maximal isometric finger dead-hangs in rock climbers
Authors: Ferrer-Uris Blai , Arias Denisse , Torrado Priscila , Marina Michel , Busquets Albert 
Published: June 2023

BackgroundMaximal isometric finger dead-hangs are used in rock climbing to strengthen finger flexors. Although various grip positions are often used when performing finger dead-hangs, little is known regarding how these grip positions can affect forearm muscle activity. Understanding how forearm muscles are recruited during dead-hangs could help foreseeing the potential for training of different grip positions. The aim of the present study was to explore the training applications of the various grip positions by comparing the activity of forearm muscles during maximal dead-hangs in rock climbers.Materials & MethodsTwenty-five climbers performed maximal dead-hangs in three climbing-specific grip positions: CRIMP, SLOPE, and SLOPER. We recorded the maximal loads used and the sEMG of the flexor digitorum profundus (FDP), the flexor digitorum superficialis (FDS), the flexor carpi radialis (FCR), and the extensor digitorum communis (EDC). Individual and global (sum of all muscles) root mean square (RMS) and neuromuscular efficiency (NME) values were computed. Repeated measures analysis were performed to assess grip differences (p < 0.05).ResultsSLOPER showed the largest maximal load values among the three grip positions (p < 0.001,d ≥ 2.772). Greater global (p ≤ 0.044,d ≥ 0.268), FDS (p ≤ 0.005,d ≥ 0.277), and FCR (p < 0.001,d ≥ 1.049) activity was observed for the SLOPER compared to CRIMP and SLOPE, while EDC (p ≤ 0.005,d ≥ 0.505) showed lower activity in the SLOPER compared to the other two grip positions. SLOPER presented the highest global (p < 0.001,d ≥ 0.629), FDP (p < 0.001,d≥ 0.777), FDS (only CRIMPvsSLOPER:p< 0.001,d= 0.140), and EDC NME (p< 0.001,d≥ 1.194). The CRIMP showed greater FDS activity (p= 0.001,d= 0.386) and lower NME (p= 0.003,d= 0.125) compared to SLOPE.ConclusionsThese results revealed that, under maximum intensity conditions, SLOPER could stimulate the FDS and FCR better than the other grip positions at the expense of using greater loads. Similarly, maximum CRIMP dead-hang could better stimulate the FDS than the SLOPE, even when using similar loads.
Ferroptosis-associated gene CISD2 suppresses colon cancer development by regulating tumor immune microenvironment
Authors: Xu Yuanyuan , Tang Qingzhu , Ding Ning , Zhang Tao , Luo Hongbiao 
Published: June 2023

Background
Despite the association of ferroptosis with various tumors, the specific mechanism by which it influences colon adenocarcinoma (COAD) microenvironmental equilibrium remains elusive. This study aims to elucidate how ferroptosis affects COAD microenvironmental homeostasis and its potential impact on COAD research.

Objective
By employing genetic screening and single-cell analysis of tumor data, we investigated the role of ferroptosis genes in COAD microenvironmental homeostasis. The genes were correlated with immune cell infiltration in tissue samples and patient outcomes.

Methods
Ferroptosis-associated genes were initially identified through the FerrDb database. Utilizing the tidyverse and Seurat packages, genes with substantial expression differences were extracted, and clustering analysis was performed on the single-cell data. A Venn diagram depicted shared differential genes for ferroptosis and tumors. To screen key ferroptosis genes, further enrichment analysis and immune cell infiltration analysis were conducted. Lastly, human COAD cell lines were employed to overexpress CDGSH iron sulfur domain 2 (CISD2) through cellular assays to validate its function in COAD.

Results
Following screening of The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases, 414 COAD patient samples and 341 normal samples were included. Through the FerrDb database, 259 ferroptosis genes were identified. Clustering the single-cell data revealed 911 tumor marker genes, of which 18 were ferroptosis genes. Analysis of variance (ANOVA) and univariate regression analysis determined that only CISD2 was statistically significantly associated with clinical outcomes. Additionally, CISD2 was found to positively correlate with activated memory T cells and negatively correlate with regulatory T cells (Tregs) and plasma cells in COAD, as well as being significantly associated with several immune-related and cancer-related pathways. CISD2 expression was elevated in most tumors, likely due to cell cycle regulation and immune system activation. Moreover, CISD2 upregulation inhibited COAD cell proliferation and enhanced 5-fluorouracil (5-FU) sensitivity. Our findings indicate, for the first time, that CISD2 governs the cell cycle and stimulates the immune system to impede COAD progression.

Conclusion
By modulating the cell cycle and mediating immune infiltration, CISD2 may inhibit COAD development by influencing tumor immune microenvironment equilibrium, providing valuable insights into the relevance and potential impact of the research results on the COAD research field.
Allelopathic Effects of Conyza canadensis Water Extract on Seed Germination and Seedling Growth
Authors: Wang Xueqin , Chen Jiahui , Li Wendi , Liang Hao , Jiang Lihua , Li Jing 
Published: June 2023

In order to investigate the effects of allelo-pathic substances of Conyza canadensis on seed germination and seedlings, this study was designed to explore the allelopathic effects of Conyza canadensis water extract (CCE) on pakchoi, spinach and lettuce. Germination rates of three crops (pakcholi, spinach, and lettuce) during the seed germination, root length, seedling height, and fresh weight of two crops (pakcholi and lettuce) during the seedling were measured under different concentrations of CCE treatment (20, 40, 60, 80, 100 g/L). The allelopathic effect index was also calculated. The results showed that CCE had a varying degree of inhibitory effect on the germination rate of the seeds of the three crops. Spinach and lettuce have significant allelopathic effects from C. canadensis. At higher concentration of CCE, the germination rate of spinach and lettuce significantly decreased (P<0.01). After germination, the root length, seedling height, and fresh weight of the crop were measured, and the allelopathic effects were also calculated. It was found that the CCE had a significant inhibitory effect on root length, but it showed a promoting effect on seedling height and fresh weight of pakchoi, and CCE had a "low promotion-high inhibition" effect on seedling height and fresh weight of lettuce.
An automatic data quality approach to assess semantic data from cultural heritage institutions
Authors: Candela Gustavo 
Published: June 2023

AbstractIn recent years, cultural heritage institutions have been exploring the benefits of applying Linked Open Data to their catalogs and digital materials. Innovative and creative methods have emerged to publish and reuse digital contents to promote computational access, such as the concepts of Labs and Collections as Data. Data quality has become a requirement for researchers and training methods based on artificial intelligence and machine learning. This article explores how the quality of Linked Open Data made available by cultural heritage institutions can be automatically assessed. The results obtained can be useful for other institutions who wish to publish and assess their collections.
Black hole horizon edge partition functions
Authors: Grewal Manvir , Law Y. T. Albert , Parmentier Klaas 
Published: June 2023

Abstract
We extend a formula for 1-loop black hole determinants by Denef, Hartnoll, and Sachdev (DHS) to spinning fields on any (d + 1)-dimensional static spherically symmetric black hole. By carefully analyzing the regularity condition imposed on the Euclidean eigenfunctions, we reveal an unambiguous bulk-edge split in the 1-loop Euclidean partition function for tensor fields of arbitrary integer spin: the bulk part captures the “renormalized” thermal canonical partition function recently discussed in [1]; the edge part is related to quasinormal modes (QNMs) that fail to analytically continue to a subset of Euclidean modes with enhanced fall-offs near the origin. Since the edge part takes the form of a path integral on Sd−1, this suggests that these are associated with degrees of freedom living on the bifurcation surface in the Lorentzian two-sided black hole geometry. For massive higher spin on static BTZ and massive vector on Nariai black holes, we find that the edge partition function is related to the QNMs with lowest overtone numbers.
Radiotherapy concepts for spinal metastases—results from an online survey among radiation oncologists of the German Society for Radiation Oncology
Authors: Waltenberger Maria , Vogel Marco M. E. , Bernhardt Denise , Münch Stefan , Dobiasch Sophie , Redmond Kristin J. , Lo Simon S. , Acker Güliz , Fehlings Michael G. , Ringel Florian , Vajkoczy Peter , Meyer Bernhard , Combs Stephanie E. 
Published: June 2023

Abstract
Purpose
Spinal metastases (SM) are a common radiotherapy (RT) indication. There is limited level I data to drive decision making regarding dose regimen (DR) and target volume definition (TVD). We aim to depict the patterns of care for RT of SM among German Society for Radiation Oncology (DEGRO) members.

Methods
An online survey on conventional RT and Stereotactic Body Radiation Therapy (SBRT) for SM, distributed via e‑mail to all DEGRO members, was completed by 80 radiation oncologists between February 24 and April 29, 2022. Participation was voluntary and anonymous.

Results
A variety of DR was frequently used for conventional RT (primary: n = 15, adjuvant: n = 14). 30 Gy/10 fractions was reported most frequently. TVD in adjuvant RT was heterogenous, with a trend towards larger volumes. SBRT was offered in 65% (primary) and 21% (adjuvant) of participants’ institutions. A variety of DR was reported (primary: n = 40, adjuvant: n = 27), most commonly 27 Gy/3 fractions and 30 Gy/5 fractions. 59% followed International Consensus Guidelines (ICG) for TVD.

Conclusion
We provide a representative depiction of RT practice for SM among DEGRO members. DR and TVD are heterogeneous. SBRT is not comprehensively practiced, especially in the adjuvant setting. Further research is needed to provide a solid data basis for detailed recommendations.
Besonderheiten und Probleme der Psychopharmakologie im Kindes- und Jugendalter
Authors: Gerlach Manfred , Renner Tobias , Romanos Marcel 
Published: June 2023

ZusammenfassungDie medikamentöse Behandlung von psychischen Erkrankungen im Kindes- und Jugendalter stellt eine besondere klinische und rechtliche Herausforderung dar. Gründe hierfür sind u. a. die häufig notwendigen Off-Label-Anwendungen und bestehende Wissenslücken in Bezug auf die Langzeitwirkungen der verwendeten Neuro‑/Psychopharmaka. In diesem Beitrag werden besondere Voraussetzungen der Therapie mit Neuro‑/Psychopharmaka, wie z. B. die Notwendigkeit der altersgerechten Einbeziehung der Kinder und Jugendlichen in den Entscheidungs- und Aufklärungsprozess sowie der Evaluation der Medikation, die Berücksichtigung biologischer alters- und reifungsabhängiger Faktoren und die besonderen Maßnahmen bei einer Off-Label-Anwendung besprochen. Weiterhin werden allgemeine Probleme bei der Entwicklung und Anwendung von Neuro‑/Psychopharmaka, wie etwa Schwierigkeiten in Bezug auf Wirknachweis, erstattungs- und haftungsrechtliche Fragen bei der Off-Label-Anwendung und die Problematik der Durchführung klinischer Studien im Kindes- und Jugendalter, diskutiert.
Eine seltene Ursache für akute Herzinsuffizienz?
Authors: Marahrens Benedikt , Petrus Dominique Sebastian 
Published: June 2023

Zusammenfassung
Hintergrund
Akute Herzinsuffizienz mit Symptomen wie Dyspnoe und Ödemen kann diverse Ursachen haben, in seltenen Fällen auch kardiale Fisteln. Wir präsentieren einen Fall von subakuter Herzinsuffizienz verursacht durch eine erworbene Fistel zwischen Aorta und rechtem Vorhof.

Fallbericht
Ein 48-jähriger Patient stellte sich mit zunehmender Belastungsdyspnoe und Ödemen der unteren Extremitäten seit circa 4 Wochen in der Klinik vor. Echokardiographisch konnte eine Fistel zwischen Aorta und rechtem Atrium nachgewiesen werden. Zum Verschluss wurde er an ein thoraxchirurgisches Zentrum überwiesen.
Magneto-convective flows around two differentially heated cylinders
Authors: Mistrangelo C. , Bühler L. , Brinkmann H-J. , Courtessole C. , Klüber V. , Koehly C. 
Published: June 2023

AbstractNumerical simulations have been carried out in support of an experimental campaign conducted in the MEKKA laboratory at KIT. The aim is investigating liquid metal heat transfer with an imposed magnetic field in a model geometry relevant for the study of water cooled lead lithium blankets for fusion reactors. In the breeding zone of this blanket concept, cooling pipes are immersed in the liquid metal in which convective motion occurs due to significant temperature gradients. The test-section features a rectangular box containing two horizontal cylinders kept at constant differential temperatures in order to establish a temperature gradient that drives the buoyant flow. A magnetic field$${\textbf{B}}$$Bis applied parallel to gravity. The magneto-convective flow, which results from the presence of electromagnetic forces and temperature gradients in the fluid, is relatively complex, since the liquid metal has to move around the cylinders. For weak magnetic fields, a convective recirculation is fed by a jet-like flow formed by the boundary layers that detach from the pipe walls and recombine behind the obstacles. For sufficiently strong$$\textbf{B}$$B, the thermal field resembles that of a conductive regime with vertical isotherms and the fluid is nearly stagnant in most of the cavity except in layers parallel to magnetic field lines and tangent to the cylinders. The rate of convective heat transfer decreases with an increase of the magnetic field. Numerical simulations complement experimental results and give insight into phenomena that cannot be directly analyzed by means of measured quantities.
Developmental, physiologic and phylogenetic perspectives on the expression and regulation of myosin heavy chains in mammalian skeletal muscles
Authors: Hoh Joseph Foon Yoong 
Published: June 2023

AbstractThe kinetics of myosin controls the speed and power of muscle contraction. Mammalian skeletal muscles express twelve kinetically different myosin heavy chain (MyHC) genes which provides a wide range of muscle speeds to meet different functional demands. Myogenic progenitors from diverse craniofacial and somitic mesoderm specify muscle allotypes with different repertoires for MyHC expression. This review provides a brief synopsis on the historical and current views on how cell lineage, neural impulse patterns, and thyroid hormone influence MyHC gene expression in muscles of the limb allotype during development and in adult life and the molecular mechanisms thereof. During somitic myogenesis, embryonic and foetal myoblast lineages form slow and fast primary and secondary myotube ontotypes which respond differently to postnatal neural and thyroidal influences to generate fully differentiated fibre phenotypes. Fibres of a given phenotype may arise from myotubes of different ontotypes which retain their capacity to respond differently to neural and thyroidal influences during postnatal life. This gives muscles physiological plasticity to adapt to fluctuations in thyroid hormone levels and patterns of use. The kinetics of MyHC isoforms vary inversely with animal body mass. Fast 2b fibres are specifically absent in muscles involved in elastic energy saving in hopping marsupials and generally absent in large eutherian mammals. Changes in MyHC expression are viewed in the context of the physiology of the whole animal. The roles of myoblast lineage and thyroid hormone in regulating MyHC gene expression are phylogenetically the most ancient while that of neural impulse patterns the most recent.
Growth in Sumsets of Higher Convex Functions
Authors: Bradshaw Peter J. 
Published: June 2023

AbstractThe main results of this paper concern growth in sums of a k-convex function f. Firstly, we streamline the proof (from Hanson et al. (Combinatorica 42:71–85, 2020)) of a growth result for f(A) where A has small additive doubling, and improve the bound by removing logarithmic factors. The result yields an optimal bound for $$\begin{aligned} |2^k f(A) - (2^k-1)f(A)|. \end{aligned}$$

|

2
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k

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)

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.

We also generalise a recent result from Hanson et al. (J Lond Math Soc, 2021), proving that for any finite $$A\subset \mathbb {R}$$

A
⊂
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$$\begin{aligned} | 2^k f(sA-sA) - (2^k-1) f(sA-sA)| \gg _s |A|^{2s} \end{aligned}$$

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k

f

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s
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≫
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where $$s = \frac{k+1}{2}$$

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=

k
+
1

2

. This allows us to prove that, given any natural number $$s \in \mathbb {N}$$

s
∈
N

, there exists $$m = m(s)$$

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=
m
(
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such that if $$A \subset \mathbb {R}$$

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⊂
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, then $$\begin{aligned} |(sA-sA)^{(m)}| \gg _s |A|^{s}. \end{aligned}$$

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This is progress towards a conjecture (Balog et al. in Electron J Comb 24(3):Paper No. 3.14, 17, 2017) which states that (1) can be replaced with $$\begin{aligned} |(A-A)^{(m)}| \gg _s |A|^{s}. \end{aligned}$$

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Developing methods of Solymosi, and Bloom and Jones, and using an idea from Bradshaw et al. (Electron J Comb 29, 2021), we present some new sum-product type results in the complex numbers $$\mathbb {C}$$
C
and in the function field $$\mathbb {F}_q((t^{-1}))$$

F
q

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t

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1

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.
Care needs of Japanese men for sexual dysfunction associated with prostate cancer treatment
Authors: Hayashi Saeko , Sato Kazuki , Oishi Fumiko , Fukuda Hiromi , Hayama Yuka , Ando Shoko 
Published: June 2023

Abstract
Purpose
Prostate cancer (PC) treatment causes sexual dysfunction (SD) and alters fertility, male identity, and intimate relationships with partners. In Japan, little attention has been paid to the importance of providing care for SD associated with PC treatment. This study is aimed at clarifying the care needs of Japanese men regarding SD associated with PC treatment.

Methods
One-to-one semi-structured interviews were conducted with 44 PC patients to identify their care needs. Data were analyzed using thematic analysis.

Results
Four core categories emerged from the analysis. (1) “Need for empathy from medical staff regarding fear of SD”: patients had difficulty confiding in others about their sexual problems, and medical staff involvement in their SD issues was lacking. (2) “Need for information that provides an accurate understanding of SD and coping strategies before deciding on treatment”: lack of information about SD in daily life and difficulty understanding information from medical institutions, caused men to regret their treatment. (3) “Need for professional care for individuals and couples affected by SD”: men faced loss of intimacy because of their partners’ unwillingness to understand their SD issues or tolerate non-sexual relationships. (4) “Need for an environment that facilitates interaction among men to resolve SD issues”: men felt lonely and wanted to interact with other patients about their SD concerns.

Conclusion
These findings may help form care strategies tailored to these needs and applicable to other societies with strong traditional gender norms.
Meningiomas of the rolandic region: risk factors for motor deficit and role of intra-operative monitoring
Authors: Maiuri Francesco , Corvino Sergio 
Published: June 2023

Abstract

Objective
Meningiomas of the rolandic region are associated to high risk of postoperative motor deficits. This study discusses the factors affecting motor outcome and recurrences from the analysis of a monoinstitutional case series and eight studies from a literature review.

Methods
Data of 75 patients who underwent surgery for meningioma of the rolandic region were retrospectively reviewed. The analyzed factors included tumor location and size, clinical presentation, magnetic resonance imaging (MRI) and surgical findings, brain-tumor interface, extent of resection, postoperative outcome and recurrence. Eight studies from literature on rolandic meningiomas treated with or without intraoperative monitoring (IOM) were reviewed with the aim to define the impact of IOM on the extent of resection and motor outcome.

Results
Among the 75 patients of the personal series, the meningioma was on the brain convexity in 34 (46%), at the parasagittal region in 28 (37%) and at the falx in 13 (17%). The brain-tumor interface was preserved in 53 cases (71%) at MRI and in 56 (75%) at surgical exploration. Simpson grade I resection was obtained in 43% of patients, grade II in 33%, grade III in 15% and grade IV in 9%. The motor function worsened postoperatively in 9 among 32 cases with preoperative deficit (28%) and in 5 among 43 with no preoperative deficit (11.5%); definitive motor deficit was evidenced in overall series at follow-up in 7 (9.3%). Patients with meningioma with lost arachnoid interface had significant higher rates of worsened postoperative motor deficit (p = 0.01) and seizures (p = 0.033). Recurrence occurred in 8 patients (11%). The analysis of the 8 reviewed studies (4 with and 4 without IOM) shows in the group without IOM higher rates of Simpson grades I and II resection (p = 0.02) and lower rates of grades IV resection (p = 0.002); no significant differences in postoperative immediate and long-term motor deficits were evidenced between the two groups.

Conclusions
Data from literature review show that the use of IOM does not affect the postoperative motor deficit Therefore, its role in rolandic meningiomas resection remains to be determined and will be defined in further studies.