bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of dwarf galaxies in f(R) gravity
Authors: de Martino Ivan , Diaferio Antonaldo , Ostorero Luisa 
Published: January 2023

ABSTRACT
We use the kinematic data of the stars in eight dwarf spheroidal galaxies to assess whether f(R) gravity can fit the observed profiles of the line-of-sight velocity dispersion of these systems without resorting to dark matter. Our model assumes that each galaxy is spherically symmetric and has a constant velocity anisotropy parameter β and constant mass-to-light ratio consistent with stellar population synthesis models. We solve the spherical Jeans equation that includes the Yukawa-like gravitational potential appearing in the weak field limit of f(R) gravity, and a Plummer density profile for the stellar distribution. The f(R) velocity dispersion profiles depends on two parameters: the scale length ξ−1, below which the Yukawa term is negligible, and the boost of the gravitational field δ &gt; −1. δ and ξ are not universal parameters, but their variation within the same class of objects is expected to be limited. The f(R) velocity dispersion profiles fit the data with a value $\xi ^{-1}= 1.2^{+18.6}_{-0.9}$ Mpc for the entire galaxy sample. On the contrary, the values of δ show a bimodal distribution that picks at $\overline{\delta }=-0.986\pm 0.002$ and $\overline{\delta }=-0.92\pm 0.01$. These two values disagree at 6σ and suggest a severe tension for f(R) gravity. It remains to be seen whether an improved model of the dwarf galaxies or additional constraints provided by the proper motions of stars measured by future astrometric space missions can return consistent δ’s for the entire sample and remove this tension.
ATOMS: ALMA three-millimeter observations of massive star-forming regions – XIII. Ongoing triggered star formation within clump-fed scenario found in the massive (∼1500 M⨀) clump
Authors: Zhang Siju , Wang Ke , Liu Tie , Zavagno Annie , Juvela Mika , Liu Hongli , Tej Anandmayee , Stutz Amelia M , Li Shanghuo , Bronfman Leonardo , Zhang Qizhou , Goldsmith Paul F , Lee Chang Won , Vázquez-Semadeni Enrique , Tatematsu Ken’ichi , Jiao Wenyu , Xu Fengwei , Wang Chao , Zhou Jian-Wen 
Published: January 2023

ABSTRACT
Whether ionization feedback triggers the formation of massive stars is highly debated. Using ALMA 3-mm observations with a spatial resolution of ∼0.05 pc and a mass sensitivity of 1.1 $\rm M_\odot$ per beam at 20 K, we investigate the star formation and gas flow structures within the ionizing feedback-driven structure, a clump-scale massive (≳ 1500 $\rm M_\odot$) bright-rimmed cloud (BRC) associated with IRAS 18290–0924. This BRC is bound only if external compression from ionized gas is considered. A small-scale (≲ 1 pc) age sequence along the direction of ionizing radiation is revealed for the embedded cores and protostars, which suggests triggered star formation via radiation-driven implosion (RDI). Furthermore, filamentary gas structures converge towards the cores located in the BRC’s centre, indicating that these filaments are fueling mass towards cores. The local core-scale mass infall rate derived from H13CO+ J = 1 − 0 blue profile is of the same order of magnitude as the filamentary mass inflow rate, approximately 1 $\rm M_\odot$ kyr−1. A photodissociation region (PDR) covering the irradiated clump surface is detected in several molecules, such as CCH, HCO+, and CS whereas the spatial distribution stratification of these molecules is indistinct. CCH spectra of the PDR possibly indicate a photoevaporation flow leaving the clump surface with a projected velocity of ∼2 km s−1. Our new observations show that RDI accompanied by a clump-fed process is operating in this massive BRC. Whether this combined process works in other massive BRCs is worth exploring with dedicated surveys.
The orbital kinematics of η Carinae over three periastra with a possible detection of the elusive secondary’s motion
Authors: Strawn Emily , Richardson Noel D , Moffat Anthony F J , Ibrahim Nour , Lane Alexis , Pickett Connor , Chené André-Nicolas , Corcoran Michael F , Damineli Augusto , Gull Theodore R , Hillier D John , Morris Patrick , Pablo Herbert , Thomas Joshua D , Stevens Ian R , Teodoro Mairan , Weigelt Gerd 
Published: January 2023

ABSTRACT
The binary η Carinae is the closest example of a very massive star, which may have formed through a merger during its Great Eruption in the mid-19th century. We aimed to confirm and improve the kinematics using a spectroscopic data set taken with the Cerro Tololo Inter-American Observatory 1.5-m telescope over the time period of 2008–2020, covering three periastron passages of the highly eccentric orbit. We measure line variability of H α and H β, where the radial velocity and orbital kinematics of the primary star were measured from the H β emission line using a bisector method. At phases away from periastron, we observed the He ii 4686 emission moving opposite the primary star, consistent with a possible Wolf–Rayet companion, although with a seemingly narrow emission line. This could represent the first detection of emission from the companion.
Dynamics of a relativistic jet through magnetized media
Authors: García-García Leonardo , López-Cámara Diego , Lazzati Davide 
Published: January 2023

ABSTRACT
The merger of two neutron stars (NSs) produces the emission of gravitational waves, the formation of a compact object surrounded by a dense and magnetized environment. If the binary undergoes delayed collapse a collimated and relativistic jet, which will eventually produce a short gamma-ray burst (SGRB), may be launched. The interaction of the jet with the environment has been shown to play a major role in shaping the structure of the outflow that eventually powers the gamma-ray emission. In this paper, we present a set of 2.5D RMHD simulations that follow the evolution of a relativistic non-magnetized jet through a medium with different magnetization levels, as produced after the merger of two NSs. We find that the predominant consequence of a magnetized ambient medium is that of suppressing instabilities within the jet and preventing the formation of a series of collimation shocks. One implication of this is that internal shocks lose efficiency, causing bursts with low-luminosity prompt emission. On the other hand, the jet-head velocity and the induced magnetization within the jet are fairly independent of the magnetization of the ambient medium. Future numerical studies with a larger domain are necessary to obtain light curves and spectra in order to better understand the role of magnetized media.
Noise-Net: determining physical properties of H iiregions reflecting observational uncertainties
Authors: Kang Da Eun , Klessen Ralf S , Ksoll Victor F , Ardizzone Lynton , Koethe Ullrich , Glover Simon C O 
Published: January 2023

ABSTRACTStellar feedback, the energetic interaction between young stars and their birthplace, plays an important role in the star formation history of the Universe and the evolution of the interstellar medium. Correctly interpreting the observations of star-forming regions is essential to understand stellar feedback, but it is a non-trivial task due to the complexity of the feedback processes and degeneracy in observations. In our recent paper, we introduced a conditional invertible neural network (cINN) that predicts seven physical properties of star-forming regions from the luminosity of 12 optical emission lines as a novel method to analyse degenerate observations. We demonstrated that our network, trained on synthetic star-forming region models produced by the warpfield-emission predictor (warpfield-emp), could predict physical properties accurately and precisely. In this paper, we present a new updated version of the cINN that takes into account the observational uncertainties during network training. Our new network named Noise-Net reflects the influence of the uncertainty on the parameter prediction by using both emission-line luminosity and corresponding uncertainties as the necessary input information of the network. We examine the performance of the Noise-Net as a function of the uncertainty and compare it with the previous version of the cINN, which does not learn uncertainties during the training. We confirm that the Noise-Net outperforms the previous network for the typical observational uncertainty range and maintains high accuracy even when subject to large uncertainties.
AGNs in post-mergers from the ultraviolet near infrared optical northern survey
Authors: Bickley Robert W , Ellison Sara L , Patton David R , Wilkinson Scott 
Published: January 2023

ABSTRACT
The kinematic disturbances associated with major galaxy mergers are known to produce gas inflows, which in turn may trigger accretion onto the supermassive black holes (SMBH) of the participant galaxies. While this effect has been studied in galaxy pairs, the frequency of active galactic nuclei (AGNs) in fully coalesced post-merger systems is poorly constrained due to the limited size or impurity of extant post-merger samples. Previously, we combined convolutional neural network (CNN) predictions with visual classifications to identify a highly pure sample of 699 post-mergers in deep r-band imaging. In the work presented here, we quantify the frequency of AGNs in this sample using three metrics: optical emission lines, mid-infrared (mid-IR) colour, and radio detection of low-excitation radio galaxies (LERGs). We also compare the frequency of AGNs in post-mergers to that in a sample of spectroscopically identified galaxy pairs. We find that AGNs identified by narrow-line optical emission and mid-IR colour have an increased incidence rate in post-mergers, with excesses of ~4 over mass- and redshift-matched controls. The optical and mid-IR AGN excesses in post-mergers exceed the values found for galaxy pairs, indicating that AGN activity in mergers peaks after coalescence. Conversely, we recover no significant excess of LERGs in post-mergers or pairs. Finally, we find that the [O iii] luminosity (a proxy for SMBH accretion rate) in post-mergers that host an optical AGN is ~0.3 dex higher on average than in non-interacting galaxies with an optical AGN, suggesting that mergers generate higher accretion rates than secular triggering mechanisms.
The smallest planetary drivers of white dwarf pollution
Authors: Veras Dimitri , Rosengren Aaron J 
Published: January 2023

ABSTRACT
Many potential mechanisms for delivering planetary debris to within a few Roche radii of white dwarfs rely on gravitational scattering events that feature perturbers which are giant planets or terrestrial planets. However, the population of these planets orbiting white dwarfs is still unknown, and for a substantial fraction of white dwarfs the largest planetary survivors of stellar evolution may be sub-terrestrial mass minor planets. Here, we attempt to identify the smallest mass perturbers that could pollute white dwarfs. Through computationally expensive numerical simulations of both unstable and stable configurations of minor planets, we find that this critical lower bound equals approximately one Luna mass (1M☾ ≈ 10-1 M♂ ≈ 10-2 M⊕ ≈ 102 MCeres). Further, we find that as this mass limit is approached from above, the typical cooling age at which white dwarf pollution occurs increases. Consequently, there is a two order-of-magnitude range of perturber masses between Earth and its moon that has remained largely unexplored in white dwarf pollution studies, despite the potential formation of thousands of such Luna-sized objects in these systems.
Tidal capture of stars by supermassive black holes: implications for periodic nuclear transients and quasi-periodic eruptions
Authors: Cufari M , Nixon C J , Coughlin Eric R 
Published: January 2023

ABSTRACT
Stars that plunge into the centre of a galaxy are tidally perturbed by a supermassive black hole (SMBH), with closer encounters resulting in larger perturbations. Exciting these tides comes at the expense of the star’s orbital energy, which leads to the naive conclusion that a smaller pericentre (i.e. a closer encounter between the star and SMBH) always yields a more tightly bound star to the SMBH. However, once the pericentre distance is small enough that the star is partially disrupted, morphological asymmetries in the mass lost by the star can yield an increase in the orbital energy of the surviving core, resulting in its ejection – not capture – by the SMBH. Using smoothed particle hydrodynamics simulations, we show that the combination of these two effects – tidal excitation and asymmetric mass-loss – results in a maximum amount of energy lost through tides of $\sim 2.5{{\ \rm per\ cent}}$ of the binding energy of the star, which is significantly smaller than the theoretical maximum of the total stellar binding energy. This result implies that stars that are repeatedly partially disrupted by SMBHs many (≳10) times on short-period orbits (≲few years), as has been invoked to explain the periodic nuclear transient ASASSN-14ko and quasi-periodic eruptions, must be bound to the SMBH through a mechanism other than tidal capture, such as a dynamical exchange (i.e. Hills capture).
Reconstruction of Plastid Proteomes of Apicomplexans and Close Relatives Reveals the Major Evolutionary Outcomes of Cryptic Plastids
Authors: Mathur Varsha , Salomaki Eric D , Wakeman Kevin C , Na Ina , Kwong Waldan K , Kolisko Martin , Keeling Patrick J 
Published: January 2023

AbstractApicomplexans and related lineages comprise many obligate symbionts of animals; some of which cause notorious diseases such as malaria. They evolved from photosynthetic ancestors and transitioned into a symbiotic lifestyle several times, giving rise to species with diverse non-photosynthetic plastids. Here, we sought to reconstruct the evolution of the cryptic plastids in the apicomplexans, chrompodellids, and squirmids (ACS clade) by generating five new single-cell transcriptomes from understudied gregarine lineages, constructing a robust phylogenomic tree incorporating all ACS clade sequencing datasets available, and using these to examine in detail, the evolutionary distribution of all 162 proteins recently shown to be in the apicoplast by spatial proteomics in Toxoplasma. This expanded homology-based reconstruction of plastid proteins found in the ACS clade confirms earlier work showing convergence in the overall metabolic pathways retained once photosynthesis is lost, but also reveals differences in the degrees of plastid reduction in specific lineages. We show that the loss of the plastid genome is common and unexpectedly find many lineage- and species-specific plastid proteins, suggesting the presence of evolutionary innovations and neofunctionalizations that may confer new functional and metabolic capabilities that are yet to be discovered in these enigmatic organelles.
Canalization of Phenotypes—When the Transcriptome is Constantly but Weakly Perturbed
Authors: Lu Guang-An , Zhang Jinning , Zhao Yixin , Chen Qingjian , Lin Pei , Tang Tian , Tang Zhixiong , Wen Haijun , Liufu Zhongqi , Wu Chung-I 
Published: January 2023

Abstract
Recent studies have increasingly pointed to microRNAs (miRNAs) as the agent of gene regulatory network (GRN) stabilization as well as developmental canalization against constant but small environmental perturbations. To analyze mild perturbations, we construct a Dicer-1 knockdown line (dcr-1 KD) in Drosophila that modestly reduces all miRNAs by, on average, ∼20%. The defining characteristic of stabilizers is that, when their capacity is compromised, GRNs do not change their short-term behaviors. Indeed, even with such broad reductions across all miRNAs, the changes in the transcriptome are very modest during development in stable environment. By comparison, broad knockdowns of other regulatory genes (esp. transcription factors) by the same method should lead to drastic changes in the GRNs. The consequence of destabilization may thus be in long-term development as postulated by the theory of canalization. Flies with modest miRNA reductions may gradually deviate from the developmental norm, resulting in late-stage failures such as shortened longevity. In the optimal culture condition, the survival to adulthood is indeed normal in the dcr-1 KD line but, importantly, adult longevity is reduced by ∼90%. When flies are stressed by high temperature, dcr-1 KD induces lethality earlier in late pupation and, as the perturbations are shifted earlier, the affected stages are shifted correspondingly. Hence, in late stages of development with deviations piling up, GRN would be increasingly in need of stabilization. In conclusion, miRNAs appear to be a solution to weak but constant environmental perturbations.
Comprehensive molecular analysis identifies eight novel variants in XY females with disorders of sex development
Authors: Kulkarni Vinayak , Chellasamy Selvaa Kumar , Dhangar Somprakash , Ghatanatti Jagdeeshwar , Vundinti Babu Rao 
Published: January 2023

AbstractDisorders of sex development (DSD) are a group of clinical conditions with variable presentation and genetic background. Females with or without development of secondary sexual characters and presenting with primary amenorrhea (PA) and a 46,XY karyotype are one of the classified groups in DSD. In this study, we aimed to determine the genetic mutations in 25 females with PA and a 46,XY karyotype to show correlations with their phenotypes. Routine Sanger sequencing with candidate genes like SRY, AR, SRD5A2, and SF1, which are mainly responsible for 46,XY DSD in adolescent females, was performed. In a cohort of 25 patients of PA with 46,XY DSD, where routine Sanger sequencing failed to detect the mutations, next-generation sequencing of a targeted gene panel with 81 genes was used for the molecular diagnosis. The targeted sequencing identified a total of 21 mutations including 8 novel variants in 20 out of 25 patients with DSD. The most frequently identified mutations in our series were in AR (36%), followed by SRD5A2 (20%), SF1 (12%), DHX37 (4%), HSD17B3 (4%), and DMRT2 (4%). We could not find any mutation in the DSD-related genes in five (20%) patients due to complex molecular mechanisms in 46,XY DSD, highlighting the possibility of new DSD genes which are yet to be discovered in these disorders. In conclusion, genetic testing, including cytogenetics and molecular genetics, is important for the diagnosis and management of 46,XY DSD cases.
Methods for analyzing the coordination and aggregation of metal–amyloid-β
Authors: Park Seongmin , Na Chanju , Han Jiyeon , Lim Mi Hee 
Published: January 2023

Abstract
The misfolding and aggregation of amyloid-β (Aβ) peptides are histopathological features found in the brains of Alzheimer's disease (AD). To discover effective therapeutics for AD, numerous efforts have been made to control the aggregation of Aβ species and their interactions with other pathological factors, including metal ions. Metal ions, such as Cu(II) and Zn(II), can bind to Aβ peptides forming metal-bound Aβ (metal–Aβ) complexes and, subsequently, alter their aggregation pathways. In particular, redox-active metal ions bound to Aβ species can produce reactive oxygen species leading to oxidative stress. In this review, we briefly illustrate some experimental approaches for characterizing the coordination and aggregation properties of metal–Aβ complexes.
A novel active transposon creates allelic variation through altered translation rate to influence protein abundance
Authors: Chen Guo , Wang Ruilin , Jiang Yizhe , Dong Xiaoxiao , Xu Jing , Xu Qiang , Kan Qiuxin , Luo Zhixiang , Springer Nathan M , Li Qing 
Published: January 2023

Abstract
Protein translation is tightly and precisely controlled by multiple mechanisms including upstream open reading frames (uORFs), but the origins of uORFs and their role in maize are largely unexplored. In this study, an active transposition event was identified during the propagation of maize inbred line B73. The transposon, which was named BTA for ‘B73 active transposable element hAT’, creates a novel dosage-dependent hypomorphic allele of the hexose transporter gene ZmSWEET4c through insertion within the coding sequence in the first exon, and results in reduced kernel size. The BTA insertion does not affect transcript abundance but reduces protein abundance of ZmSWEET4c, probably through the introduction of a uORF. Furthermore, the introduction of BTA sequence in the exon of other genes can regulate translation efficiency without affecting their mRNA levels. A transposon capture assay revealed 79 novel insertions for BTA and BTA-like elements. These insertion sites have typical euchromatin features, including low levels of DNA methylation and high levels of H3K27ac. A putative autonomous element that mobilizes BTA and BTA-like elements was identified. Together, our results suggest a transposon-based origin of uORFs and document a new role for transposable elements to influence protein abundance and phenotypic diversity by affecting the translation rate.
Structure-based investigations of the NAD+-II riboswitch
Authors: Xu Xiaochen , Egger Michaela , Li Chunyan , Chen Hao , Micura Ronald , Ren Aiming 
Published: January 2023

Abstract
Riboswitches are conserved non-coding domains in bacterial mRNA with gene regulation function that are essential for maintaining enzyme co-factor metabolism. Recently, the pnuC RNA motif was reported to selectively bind nicotinamide adenine dinucleotide (NAD+), defining a novel class of NAD+ riboswitches (NAD+-II) according to phylogenetic analysis. To reveal the three-dimensional architecture and the ligand-binding mode of this riboswitch, we solved the crystal structure of NAD+-II riboswitch in complex with NAD+. Strikingly and in contrast to class-I riboswitches that form a tight recognition pocket for the adenosine diphosphate (ADP) moiety of NAD+, the class-II riboswitches form a binding pocket for the nicotinamide mononucleotide (NMN) portion of NAD+ and display only unspecific interactions with the adenosine. We support this finding by an additional structure of the class-II RNA in complex with NMN alone. The structures define a novel RNA tertiary fold that was further confirmed by mutational analysis in combination with isothermal titration calorimetry (ITC), and 2-aminopurine-based fluorescence spectroscopic folding studies. Furthermore, we truncated the pnuC RNA motif to a short RNA helical scaffold with binding affinity comparable to the wild-type motif to allude to the potential of engineering the NAD+-II motif for biotechnological applications.