bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation into the practice of blended teaching in English courses based on the BOPPPS model
Authors: Guo Yulian 
Published: July 2023

Abstract
With the continuous development of information technology, the blended teaching mode is gradually and widely used in English teaching. Various online education platforms have emerged, most of which are student-oriented, through which teachers push various teaching resources to students in the form of text, audio, video, and other multimodal forms, mobilizing students’ visual, auditory and tactile senses to enhance students’ learning effect. It is an inevitable choice of the times for universities to use online resources, practice new education and teaching reform concepts, and constantly reflect on and reshape teaching modes. Because of the learning situation of English majors, teachers actively explore the blended teaching mode of English majors’ audio-visual courses, which helps students form good independent learning abilities and can effectively improve students’ comprehensive English application ability. However, during the initial practice, the disadvantages of blended teaching in English audio-visual courses are highlighted, which are reflected in the lack of Internet teaching resources, poor teacher and student autonomy, and an imperfect teaching evaluation system. With the help of information technology, the BOPPPS teaching model is rapidly and highly integrated with traditional English audio-visual course teaching. Based on the BOPPPS model, this paper combines the background and meaning of blended teaching in English major audiovisual speaking courses with four aspects of practical investigation: constructing a resource base, teachers’ knowledge management ability, students’ self-learning ability, and teaching evaluation system.
The results of the teaching experiment show that under the improved teaching mode of the BOPPPS model, students’ English IV exam scores improved by 13.85%, and self-learning ability improved by 21.25% compared with the control group after a period of study, which verifies the feasibility of the hybrid teaching of the BOPPPS model and promotes the convergence of English education with the international level.
Synergistic effect of acetic acid and NOXfor objects made of lead and its alloys; indoor corrosive environments in museums and depositories
Authors: Majtás D. , Mácová P. , Adámková I. , Viani A. 
Published: July 2023

AbstractComplex corrosion simulation to evaluate synergistic effect have to cover large number of factors. To do so, environmental and corrosion datasets collected by monitoring sites of interest have been used to tailor complex artificial ageing of lead and lead alloys, using lead, tin and tin-lead coupons. Material composition was based on objects of interest which are tin-lead alloy based although naming lead objects is used widespread for vast of them. To evaluate results corrosion rate based on weight loss, phase composition of corrosion product and colour change of the coupon surface were utilized. For thin corrosion layers formed micro Raman and FTIR did not provide suitable results, and GIXRD have been used.Although limited number of conditions were used for the simulations, synergistic effect was observed for lead under specific conditions. Synergistic effect do occur on lead when exposed to NOX and acetic acid fumes of relatively low concentrations (18 µg·m-3 and 500 ppb respectively).In addition, there is grouping of colourimetric data collected according to test regimes – phase composition of corrosion product respectively. This information albeit preliminary suggests that colourimetric spectroscopy may be suitable as fast and easy corrosion monitoring.
Mean perfusion pressure in cardiopulmonary bypass as a factor of intraoperative acute kidney injury
Authors: Sokolov D. V. , Akmalova R. V. , Molchan N. S. , Bovkun I. V. , Galkina O. V. , Polushin Yu. S. 
Published: July 2023

The OBJECTIVE was to evaluate the role of mean perfusion pressure in the development of acute kidney injury (AKI) in patients operated with CPB.METHODS AND MATERIALS. A retrospective monocenter observational study was conducted among patients CPB (n=97) who underwent planned heart surgery using CPB. Inclusion criteria: age over 18 years, duration of surgery from 90 to 180 minutes, no signs of end-stage renal disease. The group was divided into subgroups according to the level of mean perfusion pressure (MPP): 1st – MPP<60 mmHg, 2nd – MPP equal to and >60 mmHg. Diagnosis of AKI was carried out on the basis of changes in serum creatinine and biomarkers (NGAL, IgG, albumin in urine). The studied parameters were recorded 15 minutes after the start and end of general anesthesia as well as 24 and 48 hours after surgery.RESULTS. In the 1st subgroup, the frequency of AKI was higher: after 24 hours – 48 (78.7 %), in the 2nd subgroup – 10 (27.8 %), and after 48 hours – 21 (34.4 %) and 5 (13.9 %), respectively. In the 1st subgroup, the need for renal replacement therapy was 5 (8.2 %), while in the 2nd subgroup only 1 patient needed renal replacement therapy (2.8 %). Also, in the 1st subgroup, a higher level of lactate was detected at the end of general anesthesia – the median in the 1st subgroup was 4.6 mmol/l (2.5–11.6), in the 2nd – 2.5 mmol/l (1.4–7.2) (p= 0.022). The levels of AKI biomarkers in urine after 24 hours also differed: NGAL in the 1st – 473.1 ng/ml (235.7–749.5) and in the 2nd –111.3 ng/ ml (53.4–152.9) (p=0.003), albumin 174.6 mg/l (151.2–236.9) and 35.8 mg/l (21.3–52.5) respectively (p=0.006), IgG – 61.7 mg/l (24.9–88.5) and 9.7 mg/l (7.1–14.4) (p=0.002).CONCLUSION. Mean perfusion pressure is an important indicator of the adequacy of cardiopulmonary bypass. Lowering it below 60 mmHg leads to hypoperfusion of the kidneys with the risk of acute kidney injury.
Genetic resistance of pear cultivars to fire blight
Authors: Kapytina A. , Turuspekova S. , Kerimbek N. , Kolchenko M. , Pozharskiy A. , Askarova M. , Nizamdinova G. , Kostyukova V. , Korabayeva S. , Gritsenko D. 
Published: July 2023

The economic damage accompanying the fire blight is expressed both in the loss of crops and in the costs associated with uprooting of infected trees and restoration of fruit plantations. Pear is characterized the highest rates of susceptibility to fire blight. Development of genetically resistant cultivars is one of the crucial aspects of managing fire blight, which would allow foregoing the current economically or ecologically unsound methods such as removal of infected plants or application of antibiotics on the early stages of development. In this research, a five-year monitoring of the distribution of fire blight was performed among a collection of pear cultivars growing in a pomological garden. The cultivars ‘Ajdana’ and ‘Kirgizskaya zimnyaya’ showed the highest resistance to E. amylovora according to the results of field inspections. The infection occasions for every cultivar were confirmed by direct or indirect PCR. ‘Ajdana’ and ‘Kirgizskaya zimnyaya’ bear alleles of fire blight resistance for the CH02F06 marker, and ‘Kirgizskaya zimnyaya’ additionaly carries the resistance allele for the TsuENH017 marker. ‘Talgarskaya krasavica’ and ‘Lesnaya Krasavitsa’ are susceptible cultivars to fire blight, but at the same time their genomes include the resistance alleles for the CH02F06 marker.
Teff and Wheat Yield Variation With Phosphorus Application In Jamma District, Ethiopia
Authors: Teshome Habtemariam , Sisay Kassa , Degu Adise , Wubu Tesfaye , Hailu Tadesse 
Published: July 2023

Different plant species has different nutrient requirements and utilize nutrients in different ways. Biological activity contributes to P solubilization through mineralization, wheathering, and other physicochemical reactions so that the soil plow layer is the major source of soil availabile P for crops. Ethiopia Ministry of Agriculture and Natural Resource and ATA recommended six types of blended fertilizers (NPSZnB, NPKSB, NPKSZnB, NPSZn, NPSB and NPS) for the Amhara region. Our study was conducted in Jamma districts of eastern Amhara, Ethiopia, during 2018 cropping season to attest the yield of teff (Dega teff) and wheat (Danda’a) due to phosphorus fertilizer application. Fertilizer treatments tested were the recommended dose of N only, recommended dose of NP, 50 kg.ha-1 NPS, 100 kg.ha-1 NPS, and 150kg. ha-1 NPS, set up in a. randomized complete block design with three replication, and conducted on four sites. Our study demonstrated that applications of N and P fertilizers significantly improved grain yield of wheat and teff, and that there was significant yield differences (P < 0.05) between different rates of P fertilizer. Therefore, even though the soil P levels were shown to be sufficient, application of both N and P fertilizer in the Jamma district is essential to increase yield of teff and wheat.
СЕРЕДНЬОВІЧНА НУМІЗМАТИКА В УКРАЇНІ: ІСТОРІЯ ДОСЛІДЖЕННЯ
Authors: Shataylo Mykola 
Published: July 2023

Необхідність вивчення проблем середньовічної нумізматики неодноразово визначалась ученими як актуальний та перспективний напрямок нумізматичних досліжень в Україні. Мета статті – підсумувати стан вивчення середньовічної нумізматики в Україні, визначивши всесторонньо та якісно вивчені періоди й теми, а також виявити «білі плями» – найбільш перспективні для дослідження та маловивчені епізоди. Наукова новизна полягає у тому, що на базі аналізу результатів досліджень середньовічної нумізматики в Україні визначено найменш досліджені її складові, а відповідно, – і найбільш перспективні напрямки нумізматичних досліджень в цьому періоді.Наразі історіографічні дослідження в українській нумізматиці залишаються малочисельними. За останні десятиліття українська нумізматика збагатилася значною кількістю праць, що вимагає переосмислення досягнень вітчизняної нумізматики. В імперський період відбувалося базове накопичення інформації про знахідки монет, публікувалися історіографії монетних та скарбових знахідок. За радянського часу серед нумізматичного доробку з‘явилися тепер уже широковідомі праці із загальним оглядом історії грошового обігу, які в хронологічному порядку торкаються і висвітлюють середньовічний період. Вивчення середньовічної нумізматики в незалежній Україні дослідники здійснюють із застосуванням найрізноманітніших джерел – матеріалів архівів, музейних колекцій, газетних публікацій та Інтернет-ресурсів. Популярним видом публікації серед науковців та колекціонерів стали каталоги різновидів монет. Знахідки окремих монет та скарбових депозитів використовуються як основне джерело в дослідженні торгових та економічних зв'язків окремих регіонів України, а також при написанні підручників з нумізматики та загальних праць з історії грошового обігу.
Дослідниками були опубліковані праці з історії грошового обігу окремих регіонів, зокрема: Волині, Поділля, Подніпров‘я, Півдня та ін. Уведено до наукового обігу численні нумізматичні матеріали з колекцій музеїв, а також матеріали, знайдені під час археологічних досліджень. Значну увагу приділено вивченню проблеми фальшування монет, що здійснювалося з метою завдати збитків грошовому обігові.Висновки. У незалежній Україні набули подальшого розвитку нумізматичні дослідження найрізноманітніших окремих тематик нумізматики доби Середньовіччя. Суттєвих результатів досягнуто у вивченні монет Улусу Джучі, Червоної Руси, Подільського князівства, монет Богемії, монет Володимира Ольгердовича, монет Великого князівства Литовського, князівства Молдавського та Оcманської імперії. На наш погляд, недостатніми залишаються результати дослідження щодо монет Візантії, Давньої Руси, монетно-вагових зливків гривень, монет Венеції та Болгарії, королівства Польського, Кримського ханства, татаро-генуезьких аспрів Кафи і Тани.
Spontaneous improvement in syringomyelia in a patient with Chiari 1 malformation: illustrative case
Authors: Ozturk Oyku , Cındıl Emetullah , Emmez Hakan , Kuzucu Pelin , Celtıkcı Emrah 
Published: July 2023

BACKGROUND
“Chiari malformation” refers to a spectrum of hindbrain abnormalities characterized by impaired cerebrospinal fluid circulation through the foramen magnum. Syringomyelia is frequently found in patients with Chiari malformation type 1. Although many theories have suggested how cerebrospinal fluid enters and makes the cystic cavity in the spinal cord, the pathogenesis of syringomyelia remains controversial. This report documents a case with spontaneous resolution of syringomyelia followed up by 3-year serial magnetic resonance imaging (MRI). These kinds of cases support a more conservative approach.

OBSERVATIONS
A 59-year-old female presented to the authors’ clinic in June 2019 with a history of Chiari malformation type 1. This symptomatic patient has been followed up with serial MRI. When the last MRI was performed in August 2022, compared with previous imaging, resolution of the syringomyelia was recognized.

LESSONS
Because the natural evolution of mildly symptomatic/asymptomatic patients with syringes is unclear, these patients pose a treatment dilemma. Although surgical intervention is a widely accepted therapeutic method, a more conservative approach can be considered in cases with spontaneous resolution. Especially for patients without progressive symptoms, the surgical approach should not be considered as the first step. In view of relapses, follow-up with periodic neurological examinations and radiological imaging is preferrable.
Versatile pressure and temperature controlled cell for neutron reflectometry and small-angle neutron scattering
Authors: Bannenberg Lars J. , van Exter Martin , Verleg Malte N. , Boshuizen Bart , Parnell Steven R. , Thijs Michel , Schreuders Herman 
Published: July 2023

We have designed and realized a temperature and pressure controlled cell for Neutron Reflectometry (NR) and Small Angle Neutron Scattering (SANS) that is compatible with simultaneous optical transmission and resistivity measurements. The cell can accommodate samples up to 102 mm (4 inch) in diameter, can be pressurized from vacuum up to 10 bar gas pressure and the sample temperature can be controlled up to 350°C. The four single crystal quartz windows ensure both a good neutron and optical transmission and hence can be used in combination with in-situ optical transmission measurements. We present the cell and illustrate its performance with a series of neutron reflectometry experiments performed on Ta based thin films under a hydrogen containing atmosphere.
Meta-analysis of the effects of denosumab and romosozumab on bone mineral density and turnover markers in patients with osteoporosis
Authors: Hu Mingwei , Zhang Yifan , Guo Jianjun , Guo Cuicui , Yang Xue , Ma Xue , Xu Hao , Xiang Shuai 
Published: July 2023

PurposeTo assess the alterations in bone mineral density and bone turnover marker concentrations following the administration of denosumab and romosozumab therapies in patients with osteoporosis.MethodsPubMed was searched for studies published until January 28, 2023, that investigated the clinical efficacy and bone turnover marker changes of denosumab and romosozumab in the treatment of osteoporosis, with a minimum follow-up of 3 months in each study. Studies were screened, and data on changes in bone mineral density (BMD), P1NP, and TRACP-5b levels after treatment were extracted and included in the analysis.ResultsSix studies were analyzed. At 3 months after treatment, the romosozumab group showed greater changes in lumbar BMD and bone turnover markers. BMD of total hip and femoral neck was relatively delayed. Beginning at 6 to 12 months, romosozumab showed greater changes in bone mineral density and markers of bone turnover.ConclusionBoth romosozumab and denosumab have antiosteoporotic effects, with greater effects on BMD and bone turnover markers observed within 12 months of romosozumab treatment.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42023395034.
Multi-session transcutaneous auricular vagus nerve stimulation for Parkinson's disease: evaluating feasibility, safety, and preliminary efficacy
Authors: Lench Daniel H. , Turner Travis H. , McLeod Colin , Boger Heather A. , Lovera Lilia , Heidelberg Lisa , Elm Jordan , Phan Anh , Badran Bashar W. , Hinson Vanessa K. 
Published: July 2023

BackgroundIn pre-clinical animal models of Parkinson's disease (PD), vagus nerve stimulation (VNS) can rescue motor deficits and protect susceptible neuronal populations. Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a non-invasive alternative to traditional invasive cervical VNS. This is the first report summarizing the safety, feasibility, and preliminary efficacy of repeated sessions of taVNS in participants with PD.ObjectivesTo evaluate the feasibility, safety, and possible efficacy of taVNS for motor and non-motor symptoms in mild to moderate PD.MethodsThis is a double-blind, sham controlled RCT (NCT04157621) of taVNS in 30 subjects with mild to moderate PD without cognitive impairment. Participants received 10, 1-h taVNS sessions (25 Hz, 200% of sensory threshold, 500 μs pulse width, 60 s on and 30 s off) over a 2-week period. Primary outcome measures were feasibility and safety of the intervention; secondary outcomes included the MDS-UPDRS, cognitive function and self-reported symptom improvement.ResultstaVNS treatment was feasible, however, daily in-office visits were reported as being burdensome for participants. While five participants in the taVNS group and three in the sham group self-reported one or more minor adverse events, no major adverse events occurred. There were no group differences on blood pressure and heart rate throughout the intervention. There were no group differences in MDS-UPDRS scores or self-reported measures. Although global cognitive scores remained stable across groups, there was a reduction in verbal fluency within the taVNS group.ConclusionstaVNS was safe, and well-tolerated in PD participants. Future studies of taVNS for PD should explore at-home stimulation devices and optimize stimulation parameters to reduce variability and maximize engagement of neural targets.
The use of alteplase, although safe, does not offer clear clinical advantages when mild stroke is non-disabling
Authors: Merlino Giovanni , Nesi Lorenzo , Vergobbi Pietro , Scanni Marco Domenico , Pez Sara , Marziali Alessandro , Tereshko Yan , Sportelli Giuseppe , Lorenzut Simone , Janes Francesco , Gigli Gian Luigi , Valente Mariarosaria 
Published: July 2023

IntroductionIt is unknown whether alteplase is effective and safe in patients with mild acute ischemic stroke (AIS). Determining whether symptoms are “disabling” or not is a crucial factor in the management of these patients. This study aimed to investigate the efficacy and safety of alteplase in patients with mild, non-disabling AIS.MethodsWe included all consecutive patients admitted for AIS at our institution from January 2015 to May 2022 who presented a baseline NIHSS score of 0–5 and fit the criteria to receive intravenous thrombolysis. In order to select only subjects with non-disabling AIS, we excluded patients who scored more than 1 point in the following NIHSS single items: vision, language, neglect, and single limb. Patients who scored at least 1 point in the NIHSS consciousness item were excluded as well. This study is a retrospective analysis of a prospectively collected database.ResultsAfter the application of the exclusion criteria, we included 319 patients, stratified into patients receiving and not receiving alteplase based on non-disabling symptoms. The two groups were comparable regarding demographic and clinical data. Rates of a 3-month favorable outcome, defined as a 3-month mRS score of 0–1, were similar, being 82.3% and 86.1% in the treated and untreated patients, respectively. Hemorrhagic complications and mortality occurred infrequently and were not affected by alteplase treatment.DiscussionThis observational study suggests that the use of alteplase, although safe, is not associated with a better outcome in highly selected patients with non-disabling AIS.
Chromatic pupillometry isolation and evaluation of intrinsically photosensitive retinal ganglion cell-driven pupillary light response in patients with retinitis pigmentosa
Authors: Zhao He , Wang Hao , Zhang Minfang , Weng Chuanhuang , Liu Yong , Yin Zhengqin 
Published: July 2023

PurposeThe pupil light response (PLR) is driven by rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). We aimed to isolate ipRGC-driven pupil responses using chromatic pupillometry and to determine the effect of advanced retinitis pigmentosa (RP) on ipRGC function.MethodsA total of 100 eyes from 67 patients with advanced RP and 18 healthy controls (HCs) were included. Patients were divided into groups according to severity of visual impairment: no light perception (NLP, 9 eyes), light perception (LP, 19 eyes), faint form perception (FFP, 34 eyes), or form perception (FP, 38 eyes). Pupil responses to rod-weighted (487 nm, −1 log cd/m2, 1 s), cone-weighted (630 nm, 2 log cd/m2, 1 s), and ipRGC-weighted (487 nm, 2 log cd/m2, 1 s) stimuli were recorded. ipRGC function was evaluated by the postillumination pupil response (PIPR) and three metrics of pupil kinetics: maximal contraction velocity (MCV), contraction duration, and maximum dilation velocity (MDV).ResultsWe found a slow, sustained PLR response to the ipRGC-weighted stimulus in most patients with NLP (8/9), but these patients had no detectable rod- or cone-driven PLR. The ipRGC-driven PLR had an MCV of 0.269 ± 0.150%/s and contraction duration of 2.562 ± 0.902 s, both of which were significantly lower than those of the rod and cone responses. The PIPRs of the RP groups did not decrease compared with those of the HCs group and were even enhanced in the LP group. At advanced stages, ipRGC responses gradually became the main component of the PLR.ConclusionChromatic pupillometry successfully isolated an ipRGC-driven PLR in patients with advanced RP. This PLR remained stable and gradually became the main driver of pupil contraction in more advanced cases of RP. Here, we present baseline data on ipRGC function; we expect these findings to contribute to evaluating and screening candidates for novel therapies.
Post-activation performance enhancement of flywheel training on lower limb explosive power performance
Authors: Fu Keqi , Chen Lingying , Poon Eric Tsz-Chun , Wang Rou , Li Qian , Liu Haochong , Ho Indy Man Kit 
Published: July 2023

The study aimed to investigate the post-activation performance enhancement (PAPE) of flywheel training (FT) on lower limb explosive power performance. Using a randomized crossover design, 20 trained men (age = 21.5 ± 1.4 years; training experience 5.5 ± 1.2 years) completed seven main conditions after three familiarization sessions. The first three conditions tested the PAPE of the FT on the counter movement jump (CMJ) under three different inertial loads (0.041 kg·m2 as L; 0.057 kg·m2 as ML; and 0.122 kg·m2 as P), whereas the following four conditions tested the PAPE of FT on the 30 m sprint, which consisted of three inertial loads (L, ML, and P) and a control condition. Participants were required to perform the CMJ or 30 m sprint at baseline (Tb) and immediately (T0), 4 min (T4), 8 min (T8), 12 min (T12), and 16 min (T16) after exercise, respectively. The results of the CMJ conditions showed that PAPE peaked at T4 (p &lt; 0.01) and almost subsided at T12 (p &gt; 0.05) in ML and P conditions. Meanwhile, PAPE appeared earlier in the P condition, and the effect was more significant (P:ES = 1.09; ML:ES = 0.79). 30 m sprint results showed significant improvement only in the ML condition. The PAPE peaked at T4 (p &lt; 0.05, ES = −0.47) and almost subsided at T8 (p &gt; 0.05). It was mainly due to the significant enhancement of the 10–30 m segmental timing performance at T4 (p &lt; 0.05, ES = −0.49). This study indicates that the size of the inertial load could influence the magnitude of the PAPE produced by the explosive force of the lower limb. The PAPE of the vertical explosive force increased with increasing inertial load, but the PAPE of the horizontal explosive force did not appear at the maximum inertial load. The most effective elicitation of the PAPE was at 4–8 min after the FT.