bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness test of sunscreen cream with raw materials of coconut oil and active ingredients of Soursop (Annona Muricata L) leaf and Bay (Eugenia Polyantha Wight) leaf ethanol extracts
Authors: Widiyati Eni , Ratnawati Devi , Fitriani Dyah , Jayanti Lesta Nurul , Pangestu Nadia Arum 
Published: December 2022

The purpose of this study was to determine the effectiveness of cream made of coconut oil as a raw material and the active ingredients of soursop leaf ethanol extract and bay leaf ethanol extract as sunscreens. The cream was made by mixing the hot (700C) water phase (glycerin, distilled water, methyl paraben, and triethanolamine = TEA) and the hot (700C) oil phase (s tearic acid, coconut oil, cetyl alcohol, propyl paraben, andlanolin). After the cream was formed, the active ingredients of soursop leaf ethanol extract and bay leaf ethanol extract were added. A cream without an active ingredient was also made as a comparison. The produced cream was determined to have ultraviolet (UV) radiation absorption by using a UV spectrophotometer. The resulting absorbance value was used to calculate the value of the sun protection factor (SPF) using the Mansur equation. The results showed that creams without active ingredients had the lowest SPF values. With an SPF of 3.048, the cream with 2% active ingredients and 2.5% bay leaf extract was labeled as a low-performance sunscreen cream
Peningkatan Nilai Limbah Agroindustri Terhadap Uji Kuat Tekan Dan Uji Kuat Lentur Dalam Pembuatan Beton
Authors: Putranto Agus Martono Hadi , Saputra Bima Triza , Saka Brian Tri , Harefa Riduan Asep , Gultom Rahmat Doni Halomoan , Ardiansyah Tomi 
Published: December 2022

Telah dilakukan penelitian tentang peningkatan pemanfaatan limbah agroindustri terhadap kuat tekan dan kuat lentur dalam pembuatan beton. Dalam penelitian ini digunakan sampel dari limbah sekam padi dan cangkang sawit sebagai sumber silikanya, sedangkan untuk sumber kalsium oksidanya digunakan limbah dari kulit telur ayam ras,cangkang kepiting, cangkang udang dan cangkang kerang laut. Komposisi campuran kalsium oksida dan silika berbanding 1:1, sedangkan persentase penggantian pada semen dalam penelitian ini adalah 0%, 4%, 6%, 8%, 10%, dan 12% dari berat semen, dengan umur penyimpanan beton 14 hari, 21 hari, 28 hari dan 35 hari. Hasil penelitian menunjukkan bahwa limbah agroindustri sebagai campuran sumber kalisium oksida dan silika dapat meningkatkan uji kuat tekan dan uji kuat lentur beton pada pesentasi penggantian antara 8% - 12% pada masa simpan beton 28 dan 35 hari.
Monkeypox and its global relevance
Authors: Duarte Marvin Gonçalves , Amaral Lucas de Jesus Santana do , Lyra Zélia Maria Sarmento de Andrade Lima Fischer de , Germano Diogo Acioli Filizola , Rêgo Ana Carolina Bastos do , Lima Letícia Almeida Guedes de , Dantas Fernanda de Oliveira , Santiago Geovanna Esther Pereira , Silva Luciano Barreto , Cunha Rodolfo Scavuzzi Carneiro 
Published: December 2022

Objective: This study aimed to carry out a literature review to describe the clinical characteristics of Monkeypox, explain its means of transmission, and favor its prevention. Methodology: Searches using descriptors in PUBMED Central, BVS/BIREME, Web of Science, Scielo, The Cochrane Library, Google Scholar, and books on the subject, classified as gray literature. Results: During the review process on the therapeutic options available for the treatment and prevention of the disease, it can be concluded that the population's access to efficient health has become essential, so that there is effective control of this disease, through vaccination, prevention programs, and information to the population about the means of transmission.
Pelayanan Pendidikan yang Prima Melalui Learning Management System (LMS) Berbasis Moodle untuk Mewujudkan Sekolah Efekitf pada Masa Pandemi Covid-19 di SMP Negeri 1 Kebumen
Authors: , Martiyono , , Maesaroh , Wasliman HM. Iim , Handajani Sri 
Published: December 2022

The aims of this study were (1) to describe and analyze excellent educational services through the Moodle-based Learning Management System (LMS) at SMP Negeri 1 Kebumen and (2) to find out the impact and results for creating an effective school during the Covid-19 pandemic.
The research method used is a qualitative research method. Sources of data used are informants, namely principals, teachers, students, and parents of students as well as documents. Data collection methods used are observation, documentation, and interviews. Data analysis used descriptive qualitative techniques, with the validity of the data using triangulation of data collection techniques and sources.
Excellent educational services through the Moodle-based Learning Management System (LMS) at SMP Negeri 1 Kebumen with steps (1) planning, by forming a work team, preparing Standard Operating Procedures (POS), preparing facilities and infrastructure, and preparing development instruments, (2 ) dissemination and capacity building for teachers and administrators, students, school committees and student guardians, (3) implementation trials, (4) implementation, and (5) monitoring, evaluation and follow-up. The application of the Moodle Learning Management System (LMS) at Kebumen 1 Public Middle School can create an effective school, which is characterized by (1) efficient use of inputs, (2) effectiveness of implementing learning and management of education, both planning, outreach, testing, implementation, and monitoring, evaluation, and follow-up), (3) output productivity, namely learning and management of education that is accountable, and (4) outcome relevance, namely implementation, involvement, and student satisfaction in Learning From Home (BDR).
The Elbrus volcanic center: new features of EPR dating of rockes
Authors: Gurbanov A. G. , Koshchug D. G. , Gazeev V. M. , Leksin A. B. , Vyatkin S. V. , Dokuchaev A. Y. 
Published: December 2022

The restoration of the evolution of the Elbrus Volcanic Center (EVC) is of great importance for predicting possible eruptions. Some stages of its development fall on the time interval, which is difficult to measure by conventional radioisotope techniques. In this regard, in this work, we studied the possibility of using the dating method by radiation centers in quartz the concentration of which was measured with electron paramagnetic resonance (EPR) spectroscopy. When dating lava fl ows with an age of less than 50 thousand years, there is a good convergence of the results obtained by EPR dating, radiocarbon and comparative geomorphological methods. Due to the low thermal stability of radiation centers in quartz, in some cases, the measured values of age refl ect a later thermal impact of overlying lava fl ows or intrusive bodies. The improved technique of EPR dating with intermediate annealing led to the results that have better convergence with the data obtained by 40Ar/39Ar and K-Ar methods for rocks older than 50 thousand years.
Physical modeling of the interaction between the spreading ridge and the large Kerguelen igneous province
Authors: Agranov G. D. , Dubinin E. P. , Grokholsky A. L. 
Published: December 2022

The problem of the interaction of spreading ridges with large igneous provinces is widely discussed in the scientific literature. The most striking and well-preserved example of such interaction in the geological past is the “collision” of the Southeast Indian spreading ridge and the Kerguelen plateau, which occurred about 43 Maago. The consequence of this event was the division of a single Kerguelen plateau into two parts: in fact, the Kerguelen plateau and the Broken ridge. The conditions for the formation of these morphostructures were studied experimentally. The paper presents the results of modeling the interaction of a spreading ridge with a large igneous province. The experimental results correlate well with geological and geophysical data and with the proposed model for the development of this region.
A new sulfamate Cu3(OH)5[SO3(NH2)], a product of the anthropogene alteration of copper sulfides
Authors: Zubkova N. V. , Pekov I. V. , Chukanov N. V. , Ksenofontov D. A. , Yapaskurt V. O. , Britvin S. N. , Pushcharovsky D. Yu. 
Published: December 2022

A new basic copper sulfamate Cu3(OH)5[SO3(NH2)] of the anthropogene origin from the oxidation zone of the Murzinskoe gold deposit (Altai Krai, Russia) has been characterized with XRD and IR spectroscopy. This compound has not natural or synthetic analogue and represents a novel structure type. It is monoclinic, space group P21/c, a = 7.5817(4); b = 5.9823(3); c = 17.0084(8) Å; = 99.140(5)°; V = 761.63(7) Å3 ; Z = 4. The crystal structure of this sulfamate (R = 4.91%) is based on the distorted brucite-type layers built by Cu2+-centred octahedra of three different types: CuO2(OH)4, Cu(OH)6 and CuO(OH)5. Isolated from each other SO3NH2 tetrahedra are linked to the layers from both sides. The neighboring heteropolyhedral layers formed by Cu-centred octahedra and SO3NH2 tetrahedra are connected via the system of hydrogen bonds.
Tectonostratigraphy and history of geological development of North Caspian fold-thrust zone
Authors: Kunitsyna I. V. , Nikishin A. M. , Malyshev N. A. , Verzhbitsky V. E. , Kostenko O. V. 
Published: December 2022

The presented article is devoted to the actual problem of regional geology — the reconstruction of the history of geological development of the Upper Paleozoic-Triassic complex in the southern part of the North Caspian. Understanding of evolution is one of the necessary conditions for improving the reliability of predicting the geological objects characteristics, the structure of which determines the possibilities for the formation of hydrocarbon accumulations. Despite the rather limited data presented mainly by 2D seismic, the authors created a tectonostratigraphic model of the region. It is based on the results of integrated interpretation of geological and geophysical information, carried out using modern methodological approaches.
Analysis of Human Resource Needs for the Government of Tulung Village, Sampung Sub-district, Ponorogo Regency
Authors: Hilman Yusuf Adam , Khoirurrosyidin Khoirurrosyidin , Ridho Irvan Nur 
Published: December 2022

This research aims to map and analyze human resources needs in Tulung Village, Sampung Sub-district, Ponorogo Regency, based on law number (No) 6 of 2014. It uses descriptive and qualitative design to obtain primary and secondary data through interviews and documents, while triangulation obtained validity. The results showed that the average age of the village apparatus was around 33%, below 36-40. The replacement should be prepared because the impact on performance and mastery of technology is limited, and the distribution of education levels from senior high school is 62%. Therefore, skills improvement, educational level, and additional skills are needed to improve village apparatus.
Keywords: Village Apparatus; Good Governance; Human Resources

Abstrak
Kajian ini bertujuan untuk melakukan analisis kebutuhan SDM Pemerintahan di Desa Tulung, Kecamatan Sampung, Kabupaten Ponorogo berdasarkan regulasi atau undang-undang nomor 6 tahun 2014. Penelitian ini berjenis deskriptif kualitatif, dengan sumber data yang diperoleh dari hasil wawancara dan juga dokumen, peneliti melakukan uji triangulasi untuk memperoleh keabsahan data. Hasil penelitian memperlihatkan bahwa perangkat desa yang berusia diatas 36-40 tahun sebanyak 33%, selain itu sebesar 62% perangkat desa lulusan Sekolah Menengah Atas, kemudian dari hasil wawancara dengan perangkat desa mereka menyatakan banyak kesulitan dalam upaya beradaptasi dengan kemutahiran teknologi, yang menggangu kinerja, kondisi ini harus di sikapi dengan melakukan persiapan penggantian perangkat desa yang sudah menginjak purna sesuai amanat undang-undang, sehingga akan memperoleh kandidat perangkat yang sesuai dengan kebutuhan lembaga, selain itu ada beberapa usulan dari pemerintah desa terkait update tambahan keterampilan, supaya dapat meningkatkan kecakapan apparat desa.
Kata kunci: Perangkat Desa; Good Governance; Sumber Daya Manusia
Significance of pleural effusion detected by metagenomic next-generation sequencing in the diagnosis of aspiration pneumonia
Authors: Zhu Ling , Hao Yuqiu , Li Wei , Shi Bingqing , Dong Hongna , Gao Peng 
Published: December 2022

ObjectiveUsing metagenomic next-generation sequencing (mNGS) to profile the bacterial pathogen of pleural infection in aspiration pneumonia for therapeutic decision-making.MethodsCollection and analysis of the clinical and laboratory data of aspiration pneumonia patients who underwent mNGS detection of pleural effusion at the Second Hospital of Jilin University from November 2020 and March 2022.ResultsNine males and one female were included, aged 33 to 69 years. All patients had chest pain, fever, cough, and hypoxemia symptoms; 90% had expectoration. The laboratory tests revealed that all patients had elevated white blood cell, neutrophil, and C-reactive protein (CRP) levels. Furthermore, erythrocyte sedimentation rate (ESR) increased in 8 patients, and procalcitonin increased in only one patient. Chest CT indicated different degrees of lobar pneumonia and pleural effusion in all patients, and biochemical results implied exudative effusion according to Light criteria. Most routine culture results were negative. Among bacteria identified by mNGS, Fusobacterium nucleatum (n=9) was the most common, followed by Parvimonas micra (n=7) and Filifactor alocis (n=6). Three patients underwent surgical treatment after applying targeted antibiotics, thoracic puncture and drainage, and fibrinolytic septum treatment. After the adjusted treatment, the number of white blood cells, neutrophils, and lymphocytes decreased significantly, indicating the eradication of the infection.ConclusionsImproving the vigilance of atypical people suffering from aspiration pneumonia is essential. The mNGS detection of pleural effusion clarified the microbial spectrum of aspiration pneumonia, allowing targeted antibiotic administration.
Temporal, biomechanical evaluation of a novel, transcatheter polymeric aortic valve in ovine aortic banding model
Authors: Kachel Mateusz , Buszman Piotr P. , Milewski Krzysztof P. , Michalak Magdalena , Domaradzki Wojciech , Pruski Maciej , Sobota Michał , Fernandez Carlos , Konopko Marta , Nożyński Jerzy , Kaźmierczak Paweł , Włodarczyk Jakub , Stojko Mateusz , Bochenek Andrzej , Buszman Paweł E. 
Published: December 2022

ObjectivesThe aim of the study is to evaluate the functionality, durability, and temporal biocompatibility of a novel, balloon-expandable polymeric transcatheter heart valve (ATHV) system (InFlow, CardValve Consortium, Poland). Along with expanding TAVI indications, the demand for new transcatheter valves is increasing.MethodsA surgical ascending aortic banding model was created in 20 sheep. Two weeks later, 16 sheep were implanted with ATHV systems (15–16F). Three animals were euthanized after a 30-day follow-up, four animals after a 90-day follow-up, and six animals after a 180-day follow-up. A follow-up transthoracic echocardiography (TTE) was performed.ResultsThere was one procedure-related (6,25%) and two model-related deaths (12,5%; banding site calcification with subsequent infection originating externally from banding). TTE revealed the flow gradients (max/average) of 30,75/17,91; 32,57/19,21; and 21,34/10,63 mmHg at 30, 90, and 180 days, respectively. There were two cases of low-degree regurgitation after 180 days with no perivalvular leak observed. Histopathological analysis showed no valve degeneration at terminal follow-up with optimal healing. Small thrombi were present at the aortic wall adjacent to the base of the leaflets, and between the aortic wall and the stent in most of the valves; however, leaflets remained free from thrombi in all cases. Scanty calcifications of leaflets were reported in three animals evaluated 180 days after implantation.ConclusionThis preclinical study in the aortic banding model showed good hemodynamic performance, durability, and biocompatibility of the novel ATHV. Furthermore, regulatory studies with longer follow-ups are warranted.
A decline of protective apolipoprotein J and complement factor H concomitant with increase in C5a 3 months after cardiac surgery—Evidence of long-term complement perturbations
Authors: Laudanski Krzysztof , Liu Da , Gullipalli Damodar , Song Wen-Chao , Okeke Tony , Szeto Wilson Y. 
Published: December 2022

BackgroundHeart surgery results in complement activation with the potential for collateral end-organ damage, especially if the protective elements (complement factor H, Apolipoprotein J) are inadequate. Here, we have investigated if peri-operative stress results in an imbalance between complement activation and its protective mechanisms up to 3 months after heart surgery.Methods101 patients scheduled for non-emergent cardiac surgery donated blood before the procedure (tbaseline), and 24 h (t24h), 7 days (t7d) and 3 months (t3m) after. Complement activation was measured as a serum level of soluble activated component 5 (sC5a) and soluble terminal complement complex (sTCC). Simultaneously, protective complement factor H (CfH), and apolipoprotein J (ApoJ) were measured. Inflammatory responses were quantified using C-reactive protein (CRP) and interleukin-6 (IL-6). Details regarding anesthesia, intensive care unit (ICU) stay, pre-existing conditions, the incidence of postoperative complications, and mortality were collected from medical records.ResultsC5a declined at t24h to rebound at t7d and t3m. sTCC was significantly depressed at t24h and returned to baseline at later time points. In contrast, CfH and ApoJ were depressed at t3m. Milieu of complement factors aligned along two longitudinal patterns:cluster#1 (C5a/sTTC continuously increasing and CfH/ApoJ preserved at tbaseline) and cluster#2 (transient sC5a/sTTC increase and progressive decline of CfH). Most patients belonged to cluster #1 at t24h (68%), t7d (74%) and t3m (72%). sTCC correlated with APACHE1h (r2 =−0.25; p &lt; 0.031) and APACHE24h (r2 = 0.27; p &lt; 0.049). IL-6 correlated with C5a (r2 =−0.28; p &lt; 0.042) and sTTC (r2 =−0.28; p &lt; 0.015). Peri-operative administration of acetaminophen and aspirin altered the complement elements. Prolonged hospital stay correlated with elevated C5a [t (78) = 2.03; p = 0.048] and sTTC serum levels [U (73) = 2.07; p = 0.037]. Patients with stroke had a decreased serum level of C5a at t7d and t3m.ConclusionThere is a significant decrease in complement protective factors 3 months after cardiac surgery, while C5a seems to be slightly elevated, suggesting that cardiac surgery affects complement milieu long into recovery.
Follicle-stimulating hormone and blood lead levels with bone mineral density and the risk of fractures in pre- and postmenopausal women
Authors: Tong Huixin , Su Bo , Liu Zhize , Chen Yongjie 
Published: December 2022

BackgroundThe conclusions on the associations of serum follicle-stimulating hormone (FSH) and blood lead levels with bone mineral density (BMD) were controversial. Furthermore, little was known on the impacts of co-existence of serum FSH and blood lead levels on BMD and the risk of fractures in premenopausal and postmenopausal women. Therefore, the present study aimed to examine the associations of serum FSH and blood lead levels with BMD and the risk of fractures in premenopausal and postmenopausal women.MethodsData were derived from the National Health and Nutrition Examination Survey. FSH is assayed using the Microparticle Enzyme Immunoassay technology. Blood lead levels were measured using atomic absorption spectrometry. BMD was measured using dual energy X-ray absorptiometry. Fractures were defined as subjects with fractures in any site of hip, wrist, and spine.ResultsThis study included 3798 participants. Elevated blood lead levels were associated with increased serum FSH levels (β= 48.22, 95% CI: 40.21~ 56.22). Serum FSH levels were negatively associated with total femur BMD in pre- and postmenopausal women. However, elevated serum FSH levels were associated with a lower lumbar spine BMD and a higher risk of fractures only in postmenopausal women (β= -0.0010, 95% CI: -0.0015~ -0.0006; OR: 1.007, 95% CI: 1.000~1.014, respectively).ConclusionsSerum lead levels were associated with serum FSH levels. Serum FSH levels were associated with a lower BMD and a higher risk of fractures.
Explaining the polarized macrophage pool during murine allergic lung inflammation
Authors: Draijer Christina , Florez-Sampedro Laura , Reker-Smit Catharina , Post Eduard , van Dijk Fransien , Melgert Barbro N. 
Published: December 2022

IntroductionDifferentially polarized macrophages, especially YM1+ and MHCII+ macrophages, play an important role in asthma development. The origin of these polarized macrophages has not been elucidated yet. We therefore aimed to investigate how proliferation, monocyte recruitment, and/or switching of polarization states contribute to this specific pool of polarized interstitial and alveolar macrophages during development of house dust mite (HDM)-induced allergic lung inflammation in mice.MethodsMale and female mice were first treated intranasally with PKH26 to label lung-resident macrophages and were then exposed to either HDM or phosphate-buffered saline (PBS) for two weeks. Different myeloid immune cell types were quantified in lung tissue and blood using flow cytometry.ResultsWe found that macrophage polarization only starts up in the second week of HDM exposures. Before this happened, unpolarized alveolar and interstitial macrophages transiently increased in HDM-exposed mice. This transient increase was mostly local proliferation of alveolar macrophages, while interstitial macrophages also contained unlabeled macrophages suggesting monocyte contribution. After two weeks of exposures, the number of interstitial and alveolar macrophages was similar between HDM and PBS-exposed mice, but the distribution of polarization states was remarkably different. HDM-exposed mice selectively developed YM1+ alveolar macrophages and MHCII-hi interstitial macrophages while nonpolarized macrophages were lost compared to PBS-exposed mice. DiscussionIn this HDM model we have shown that development of a polarized macrophage pool during allergic inflammation is first dependent on proliferation of nonpolarized tissue-resident macrophages with some help of infiltrating unlabeled cells, presumably circulating monocytes. These nonpolarized macrophages then acquire their polarized phenotype by upregulating YM1 on alveolar macrophages and MHCII on interstitial macrophages. This novel information will help us to better understand the role of macrophages in asthma and designing therapeutic strategies targeting macrophage functions.