bluuebunny/crossref_metadata_2025_split huggingface dataset:
Six-month stability following extensive alveolar bone augmentation by sausage technique
Authors: Kim Kang-min , Choi Soo-young , Park Jung-Hyun , Kim Heon-Young , Kim Sun-Jong , Kim Jin-Woo 
Published: April 2023

AbstractBackgroundResorption of alveolar bone is a common sequela of tooth loss and presents a clinical problem, especially in the esthetic zone. When ridge resorption occurs, adequate bone augmentation is essential to obtain satisfactory esthetic results. The purpose of this study was to determine the increase and retention rate of bone height or width in patients who received extensive bone augmentation and to analyze factors affecting its prognosis and stability.MethodsThis study was performed on patients who received extensive bone augmentation by sausage technique at the Department of Oral and Maxillofacial Surgery at Ewha Womans University Mok-dong Hospital from January 1, 2018, to February 28, 2022. CBCT images were taken before and 6 months after surgery to compare the amount of increase in bone height or width at the graft site. They were measured using reliable points such as adjacent implants or cephalometric landmarks, inferior alveolar nerve canals as reference points.ResultsA total of 8 patients underwent extensive bone grafting during the given period (mean age was 53.75 years, 2 males and 6 females). Four patients received horizontal augmentation, and 4 received vertical augmentation. When divided by surgical site, 4 patients are in maxilla and 4 in mandible. The average amount of increase in bone width or bone height was 5.38 mm, and the retention rate was about 79.9% after 6 months. The retention rate of horizontal augmentation was 88.8%, which was higher than that of vertical augmentation, which was 74.5%. The maxillary area accounted for 92.2%, and the amount of bone resorption was lower than that of the mandibular area, which was 72.6%. The average stitch out period was about 2.4 weeks, and postoperative dehiscence was observed about 37.5% of the total, more frequently in the mandible (50.0%) than in the maxilla (25.0%).ConclusionIn conclusion, extensive bone augmentation achieved significant horizontal or vertical bone height or width increase, and the retention rate after 6 months was also high. In addition, surgery in the maxillary region showed a more successful bone augmentation than in the mandible, with a higher maintenance rate and fewer cases of dehiscence.
A holistic view of maritime navigation accidents and risk indicators: examining IMO reports from 2011 to 2021
Authors: Dominguez-Péry Carine , Tassabehji Rana , Corset Franck , Chreim Zainab 
Published: April 2023

AbstractThis paper investigated the risk indicators in maritime accidents and how they are considered within the reporting of maritime accidents, drawing on ten years of International Maritime Organisation (IMO) (2011–2020) accident reports. It highlighted the lack of consistent findings in studies exploring the role of vessel characteristics in maritime accidents, which often result from different methods, databases, techniques and motivations used by each respective study for gathering and analysing data. Furthermore, as human error continues to be highlighted as the top-cited cause of accidents, this study examined the qualitative content of IMO accident reports in-depth to broaden our understanding of maritime accident risk factors. Using a data-driven approach, statistical (ANOVA) and advanced text-mining techniques (using IRAMUTEQ software) were applied to extract meaning from the semi-structured and unstructured narrative descriptions that constitute most of the national administrations’ investigation reports to the IMO. Building on the text analysis of the IMO accident data, we proposed the Accident Maritime Ecosystem framework, which incorporates individuals, the ship organisation (on board), the internal ship ecosystem (on board and onshore), the external ship ecosystem (external factors) and the global maritime ecosystem (policies and regulations); moreover, it identifies these entities as risk factors in maritime accidents. The findings illustrate how accident reporting is largely human-centric and that as maritime transportation is becoming increasingly complex, there is a need for policy and organisational decision-makers to incorporate a broader scope of actors when considering maritime risk factors, which can be achieved by using the AME framework as a guideline.
Neuropsychiatric manifestations and magnetic resonance spectroscopy of the brain in systemic lupus erythematosus patients
Authors: Shahin Dina A. , Hegazy Khaled M. F. , Elsherif Mohammed , Sayed-Ahmed Nagy A. , Elwasify Mohamed , Helmy Eman , Abdel Razek Ahmed Abdel Khalek , Tharwat Samar 
Published: April 2023

AbstractBackgroundNeuropsychiatric manifestations of lupus (NPSLE) are considered one of the major and most devastating lupus manifestations. The aim of this study was to assess the neuropsychiatric manifestations in systemic lupus erythematosus (SLE) patients and estimate the effectiveness of brain magnetic resonance spectroscopy (MRS) and anti-ribosomal P antibody test in early detection of NPSLE. This cross-sectional study was carried out on 50 SLE patients. Demographic, clinical, and therapeutic data were assessed. All patients were subjected to thorough rheumatological and neuropsychiatric evaluation. Serologic tests included antinuclear antibodies, anti-double-stranded DNA, and anti-ribosomal P protein antibodies. Radiologic evaluation included brain MRS.ResultsThe mean age was 26.9 ± 98.9 years; the median disease duration was 18 (0–108) months. Headache was the most common neurological symptom (40%). Depression was not detected in 29 patients (58%), mild in 15 patients (30%), and moderate in 6 patients (12%). Anti-ribosomal P antibody titer was significantly elevated in patients with active in comparison with those with inactive lupus disease (p= 0.026). Brain MRS showed a statistically significant reduction in N-acetylaspartate creatine ratio (NAA/Cr) among patients with active lupus disease (p= 0.015) with a statistically significant increase in choline creatine ratio (Cho/Cr) among patients with inactive lupus disease (p= 0.049). There was a statistically significant negative correlation between the level of NAA/Cr and anti-ribosomal P antibody titer among patients with active lupus disease (p< 0.001).ConclusionsHeadache is the most common neurological manifestation among SLE patients. Anti-ribosomal P antibody titer is elevated in active SLE patients. The changes of NAA/Cr and Cho/Cr in brain MRS can be of help to differentiate between the active and inactive SLE.
Clinical profile of duplex kidneys in children and its association with vesicoureteric reflux
Authors: Perveen K Athiya , Mathews Shirbin Joe , Varghese Thomas P 
Published: April 2023

Abstract
Background
Duplex kidney is a relatively common renal anomaly with a wide array of associations. With routine antenatal screening it is increasingly diagnosed these days. With this study, we aim to assess the clinical profile, prevalence of vesicoureteric reflux and highlighting the need for aggressive workup and management in selected cases to prevent further renal damage.

Results
Fifty-three children with duplex kidneys who attended the department of pediatric surgery at our institution from December 2016 to December 2021 were included in the study. The most common mode of presentation was urinary tract infection (58%). Fifty-three percent had an antenatally detected renal anomaly (out of these 46% were asymptomatic, 33% had UTI and 11% had other symptoms like straining, incontinence and abdominal mass). Sixty-one percent of patients were conservatively managed and 19 patients needed surgical intervention. Ureterocele was the most common condition necessitating surgery. Prevalence of vesicoureteric reflux was 60% and was comparable with other studies. Thirty-six percent of patients had renal scarring. Among the patients with scarring, 84% had VUR and 63% had febrile UTI.

Conclusion
Duplex kidney though a common congenital anomaly, requires a systematic evaluation to detect its various associations and a structured management protocol according to the associations. It has a high incidence of VUR which is a potentially hazardous condition which can affect the renal function if not evaluated and managed appropriately. Duplex can also be associated with obstructive conditions like PUJO, ureterocele, and ectopic megaureter which can cause rapid deterioration of renal function if not managed early enough. Though majority of the patients need only follow-up and antibiotic prophylaxis, there may be a certain sub group of patients who develop early scarring and need aggressive management. Our study aims to highlight the need to detect such patients early enough to reduce the morbidity.
In vitro characterization of self-emulsifying drug delivery system-based lipsticks loaded with ketoconazole
Authors: Prajapati Bhupendra G. , Paliwal Himanshu , Shah Parth A. 
Published: April 2023

AbstractBackgroundSelf-emulsifying system-based lipstick may prove to have the potential of enhancing moisturizing characteristics and delivering hydrophobic drug antifungal drugs for the management of lip fungal infection, especially candidiasis. In this study, the self-emulsifying drug delivery system (SEDDs) of ketoconazole was obtained using IPM (Oil), Tween 80 (surfactant), and PEG 400 (co-surfactant). The medicinal lipstick was developed from the SEDDs, and the concentration of waxes (beeswax and carnauba wax) and cow ghee (penetration enhancer) was optimized using a Box–Behnken design. The lipstick formulations were assessed based on physicochemical features, such as pH, spreadability, softening point, breaking point, content uniformity, and in vitro drug permeation. Furthermore, the optimal lipstick formulation was tested for stability and antifungal activity.ResultsThe optimized formulation showed exceptional results in physicochemical analysis and ~ 87% release of the drug in 12 h. The formulations displayed adequate stability for 4 weeks at various temperature conditions such as room temperature, 40 °C, and 45 °C. The zone of inhibition produced by lipstick formulation was significantly higher as compared to the reference standard (ketoconazole in ethanol) which shows high antifungal activity.ConclusionIt was concluded from the outcomes that SEDDs-based lipstick formulation showed a lot of promise as a topical antifungal treatment option for Candidiasis.Graphical abstract
Gastro-esophageal and respiratory morbidity in children after esophageal atresia repair: a 23-year review from a single tertiary institution in Asia
Authors: Chiang Jayne , Yap Te-Lu , Arif Shaista , Choo Candy S. C. , Pugalenthi A. K. , Thomas Biju , Jacobsen Anette S. , Ong Lin Yin 
Published: April 2023

Abstract
Background
Improved survival of neonates with esophageal atresia with/without tracheoesophageal fistula (EA/TEF) has resulted in increased prevalence of gastro-esophageal and respiratory-related morbidities. However, long-term outcome data on these patients remains limited, making it difficult to substantiate any guidelines on their chronic care. The purpose of our study is to report on their post-operative outcomes especially the long-term gastro-esophageal and respiratory morbidities.

Methods
This was a retrospective review of 65 patients (39 males, 26 females) who underwent EA/TEF repair from 1996 to 2019 at a single tertiary institution. Follow up data pertaining to clinical characteristics, operative management and long-term gastro-esophageal and respiratory morbidities was analyzed.

Results
Fifty-seven patients (87.7%) had Gross Type-C anatomy, followed by 5(7.7%) patients with Type-A, 1(1.5%) with Type-B and 1 with Type-D. One patient had a late diagnosis of H-type fistula (Type-E). Thirteen (20%) patients had long-gap EA.
Median age at first surgery was day 1 (IQR 1–2) of life. All patients underwent bronchoscopy at their index surgery. All 52 non-long gap EA (LGEA) patients underwent primary anastomosis, while most (76.9%) LGEA patients underwent staged repair. Post-operatively, 4(6.2%) developed anastomotic leak which resolved with conservative management. Three (4.6%) had recurrent TEF, 2 underwent re-do ligation. Twenty (30.8%) patients developed anastomotic strictures, with 15 requiring serial dilatation.
Long-term burden of gastro-esophageal and respiratory morbidity was high (63.1%; 64.6% respectively). The majority (n = 39,60%) of patients required active follow-up for a median duration of 5 years (IQR 1.5–10 years). Predominant conditions were gastroesophageal reflux disease (n = 28, 43.1%), dysphagia (n = 20, 30.8%), recurrent respiratory infections (n = 23, 35.3%), chronic cough (n = 19, 29.2%), and pneumonia (n = 19, 29.2%). Tracheomalacia was diagnosed in 22(33.8%), 2 of whom required tracheostomy for severe disease. Overall mortality rate was 10.8% (n = 7): 5 demised due to chronic respiratory failure, while 2 demised intra-operatively during the index surgery.

Conclusion
Despite successful surgical repair for EA/TEF, our data demonstrated significant morbidities among EA/TEF survivors, thus highlighting the importance of long-term multi-disciplinary care with collaboration between respiratory, gastroenterology, and otolaryngology specialists.

Level of evidence
Prognostic, Level IV.
Metabolic accompaniment of quantitative-qualitative blood pressure clusters in patients of Truskavets’ spa
Authors: Kozyavkina Nataliya , Vovchyna Yuliya , Voronych-Semchenko Nataliya , Zukow Walery , Popovych Igor 
Published: April 2023

Background. Earlier we studied the neural and endocrine accompaniments of quantitative-qualitative blood pressure (BP) clusters of profile patients of Truskavets’ spa. The purpose of this study is to clarify the metabolic accompaniment in the same contingent. Materials and methods. Under an observations were 44 patients with chronic pyelonephritis and cholecystitis in the phase of remission. Testing was performed twice - on admission and after 7-10 days of standard balneotherapy. The main object of the study was BP (tonometer “Omron M4-I”, Netherlands). The plasma levels of lipids, glucose, nitrogenous metabolites and electrolytes as well as urinary excretion of last two were determined. In addition, electrokinetics and cholecystokinetics indexes were determined. Results. The forward stepwise program identified 21 parameters as characteristic of quantitative-qualitative blood pressure clusters. In addition to BP parameters by default, the most informative among them are sodium and uric acid daily excretion as well as plasma phosphate and magnesium, whose levels are maximal in patients with hypertension, while minimal in patients with low norm BP, on the one hand, and electrokinetics index, the level of which are polar, on the other hand. The accuracy of patient classification is 97,7%. Conclusion. The quantitative-qualitative blood pressure clusters have a characteristic metabolic accompaniment.
Alflutop Russian longitudinal multicentre observational study: preliminary results (message 1)
Authors: Lila A. M. , Alekseeva L. I. , Taskina E. A. , Kashevarova N. G. 
Published: April 2023

Evaluation of the effect of new drugs should be carried out in randomized controlled trials (RCTs), and observational studies (OSs) are carried out to confirm and refine the results obtained in RCTs, for example, to study the effectiveness of drugs in large groups of patients who were not included in RCTs or had comorbidities or older age.Objective: to evaluate the effectiveness of Alflutop (AF) via OS of patients with osteoarthritis (OA) of the knee and/or hip joints and/or low back pain (LBP) with or without comorbid diseases.Material and methods. A multicenter prospective cohort OS was conducted in 163 clinical centers in 58 cities of the Russian Federation and included 22,525 patients with OA and LBP who received AF as a part of a planned treatment prescribed by a doctor, or self-prescribed and purchased in a pharmacy. Pain, satisfaction with therapy, health assessment, need for non-steroidal anti-inflammatory drugs (NSAIDs), and quality of life were recorded using the EQ-5D questionnaire.Results and discussion. After one treatment course with AF, improvement was detected in 98% of cases, there was a rapid positive trend with a significant decrease in pain, the median time to clinical effect was 8 [5; 10] days. Assessment of general health status and satisfaction with therapy improved significantly. In 94.5% of patients, the daily requirement for NSAIDs decreased.Conclusion. The first results from the OS confirm the symptomatic effect of AF.
Modern approaches in the treatment of oncological pain: surgical treatment
Authors: Yarikov A. V. , Kuznetsov S. F. , Dubskikh A. O. , Fraerman A. P. , Perlmutter O. A. , Kabardaev R. M. , Khinovker V. V. 
Published: April 2023

Based on the analysis of modern literature, surgical approaches to the treatment of chronic pain syndrome in cancer patients are presented. The definition and classification of chronic pain syndrome is given, its pathophysiology is described. The frequency of occurrence in the population and its dependence on the stage and localization of malignant neoplasm is shown. For practical use, an algorithm for the diagnosis of chronic pain syndrome and the basic principles of its therapy are presented. As the 4th step of the World Health Organization pain relief ladder, surgical methods for the treatment of chronic pain syndrome are separately considered. Three main types of surgical interventions (neuromodulating, neurodestructive and anatomical) are described, indications and contraindications to their use are indicated.
Regional lymphadenectomy in the treatment of patients with melanoma skin with metastases in the sentinel lymph nodes
Authors: Abramova O. E. , Kudryavtsev D. V. , Kurilchik A. A. , Ivanov S. A. 
Published: April 2023

Regional recurrences are one of the most common first manifestations of progression of clinically localized cutaneous melanoma. They are caused by subclinical metastases in the lymph nodes. Biopsy of the sentinel lymph nodes is the most effective method of detection of hidden regional metastases. It allows to appropriately increase the volume of surgical treatment prior to dissection of the affected lymph collector and perform adjuvant therapy with the most effective drugs. This, in its turn, allows for significant improvement of regional and systemic control of the disease and long-term treatment outcomes.Data obtained in several randomized trials on the effectiveness of lymph node dissection in patients with sentinel lymph node metastasis showed that this procedure significantly improves regional control of the disease but does not affect long-term treatment outcomes. Additionally, some studies showed that assignment of responsibility for regional control to adjuvant therapy does not meet the expectations. Therefore, the most effective method of regional control of cutaneous melanoma is surgery. All of these studies show that it is necessary to develop criteria for identification of patients with high risk of metastases in the non-sentinel lymph nodes who require lymph node dissection for regional disease control and creation of the best conditions for adjuvant systemic therapy. This requires identification of predictors of multiple involvement of regional lymph nodes justifying indications for radical lymph node dissection. Studies in this area are being performed but their results are ambiguous and sometimes contradictory.Aim. To evaluate the effectiveness of lymph node biopsy and radical lymph node dissection in patients with cutaneous melanoma and subclinical involvement of the sentinel lymph node.
Long-term results of isolated limb perfusion with hyperthermia in patients with limb melanoma
Authors: Petrochenko N. S. , Kharatishvili T. K. , Valiev A. K. , Buydenok Yu. V. , Kaspshik S. M. , Gribkova E. I. , Salkov A. G. 
Published: April 2023

Introduction. In patients with local recurrences of melanoma or with transit metastases of this tumor located distal to the axilla and inguinal region, the use of isolated regional limb perfusion is considered as one of the effective treatment options.Aim. To evaluate the long-term results of treatment extremities melanoma using the method of isolated regional perfusion of the extremities.Materials and methods. An analysis of the treatment and observation results of 72 patients (12 men and 60 women) with melanoma of the extremities was carried out, the median age was 56.7 years (from 25 to 78 years). All patients underwent isolated regional perfusion with hyperthermia using melphalan at doses of 10 mg/l volume for the lower limb and 13 mg/l volume for the upper limb. Patient survival for 5 years, the incidence of relapses and metastases of melanoma, as well as the frequency of limb amputation were assessed.Results. The rate of complete response to treatment was 13.9 %, in the vast majority of cases there was a partial regression – in 72.2 % of cases. There was no response to treatment in only 13.9 % of patients.Recurrence of transit metastases within 5 years developed in 52 (72.2 %) patients. Amputation was performed only in 11.1 % of cases. The 1-year survival rate was 91.7 %, the 5-year survival rate for melanoma patients who underwent isolated regional perfusion was 55.6 %.Сonclusion. Isolated regional perfusion under conditions of hyperthermia with melphalan is an effective and safe method of treatment in terms of long-term results of melanoma treatment, providing a 5-year patient survival rate of 55.6 %, a low rate of amputations and metastasis.