bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Liposomal Bupivacaine Injectable Suspension Peripheral Nerve Block Further Aid in Decreasing At-home Narcotic Utilization in Children and Adolescents After Anterior Cruciate Ligament Reconstruction
Authors: Walls Halle R. , Thomas Evelyn S. , Kain Zeev N. , Schlechter John A. 
Published: July 2023

Background:
Opioid misuse and addiction among children and adolescents is an increasingly concerning problem. This study sought to determine whether liposomal bupivacaine injectable suspension admixture administered as a single-shot adductor canal peripheral nerve block (SPNB+BL) would decrease utilization of at-home opioid analgesics after anterior cruciate ligament reconstruction (ACLR) in adolescents compared with single-shot peripheral nerve block with bupivacaine (SPNB+B) alone.

Methods:
Consecutive ACLR patients with or without meniscal surgery by a single surgeon were enrolled. All received a preoperative single-shot adductor canal peripheral nerve block with either admixture of liposomal bupivacaine injectable suspension with 0.25% bupivacaine (SPNB+BL) or 0.25% bupivacaine alone (SPNB+B). Postoperative pain management included cryotherapy, oral acetaminophen, and ibuprofen. A prescription for 10 doses of hydrocodone/acetaminophen (5/325 mg) was provided in a sealed envelope with instructions to only use in the case of uncontrolled pain. Pain using the visual analog scale; number of consumed narcotics, acetaminophen, ibuprofen, and pain treatment satisfaction for the first 3 postoperative days were recorded. Statistical analysis was performed.

Results:
Fifty-eight patients were enrolled, the average age was 15±1.5 years (SPNB+B=32 patients, SPNB+BL=26 patients). Forty-seven patients (81%) did not require home opioids postoperatively. A significantly lower proportion of patients in the SPNB+BL group required opioids compared with control patients (7.7% vs. 28.1%, P=0.048). Average opioid use was 2 morphine milligram equivalents (MME), 0.4 pills (range, 0 to 20 MME). There were no differences in the visual analog scale or pain treatment satisfaction scores, other demographics, or other operative data. Inverse probability of treatment weighting analysis that was performed to account for any potential group differences revealed home opioid use between groups is significantly different (P<0.001).

Conclusions:
Liposomal bupivacaine injectable suspension admixture administered as an adductor canal nerve block in adolescents undergoing ACLR effectively reduces home opioid usage postoperatively compared with bupivacaine alone.

Level of Evidence:
Level II—prospective comparative study.
Relative efficacy and safety of several regional analgesic techniques following thoracic surgery: a network meta-analysis of randomized controlled trials
Authors: Li Jie , Sun Qingchao , Zong Liang , Li Desheng , Jin Xiaoliang , Zhang Liwei 
Published: July 2023

Background:This network meta-analysis was performed to assess the relative efficacy and safety of various regional analgesic techniques used in thoracic surgery.Materialsand methods:Randomized controlled trials evaluating different regional analgesic methods were retrieved from databases, including PubMed, Embase, Web of Science, and the Cochrane Library, from inception to March 2021. The surface under the cumulative ranking curve) was estimated to rank the therapies based on the Bayesian theorem. Moreover, sensitivity and subgroup analyses were performed on the primary outcomes to obtain more reliable conclusions.Results:Fifty-four trials (3360 patients) containing six different methods were included. Thoracic paravertebral block and erector spinae plane block (ESPB) were ranked the highest in reducing postoperative pain. As for total adverse reactions and postoperative nausea and vomiting, postoperative complications, and duration of hospitalization, ESPB was found to be superior to other methods. It should be noted that there were few differences between various methods for all outcomes.Conclusions:Available evidence suggests that ESPB might be the most effective and safest method for relieving pain after thoracic surgery, shortening the length of hospital stay and reducing the incidence of postoperative complications.
Four-Point Impedance and Utricular Dysfunction Is Associated with Postoperative Dizziness after Cochlear Implantation
Authors: Tan Eren , Bester Christofer , Collins Aaron , Razmovski Tayla , O’Leary Stephen 
Published: July 2023

AbstractIntroductionPostimplantation dizziness is common, affecting approximately 50% of patients. Theories for dizziness include utricular inflammation, endolymphatic hydrops, and loss of perilymph. Four-point impedance (4PI) is a novel impedance measurement in cochlear implantation that shows potential to predict hearing loss, inflammation, and fibrotic tissue response. Here, we associate 4PI with dizziness after implantation and explore the link with utricular function.MethodsSubjective visual vertical (SVV) as a measure of utricular function was recorded preoperatively as a baseline. 4PI was measured immediately postinsertion. Ongoing follow-up was performed at 1 day, 1 week, and 1 month, postoperatively. At each follow-up, 4PI, SVV, and the patients’ subjective experience of dizziness were assessed.DiscussionThirty-eight adults were recruited. One-day 4PI was significantly higher in patients dizzy within the next week (254 Ω vs 171 Ω,p= 0.015). The optimum threshold on receiver operating characteristic curve was 190 Ω, above which patients had 10 times greater odds of developing dizziness (Fisher exact test, OR = 9.95,p= 0.0092). This suggests that 4PI varies with changes in the intracochlear environment resulting in dizziness, such as inflammation or hydrops. SVV significantly deviated away from the operated ear at 1 day (fixed effect estimate = 2.6°,p≤ 0.0001) and 1 week (fixed effect estimate 2.7°,p≤ 0.001).ConclusionOne-day 4PI is a potentially useful marker for detecting postoperative dizziness after cochlear implantation. Of the current theories for postoperative dizziness, inflammation might explain the findings seen here, as would changes in hydrostatic pressure. Future research should focus on detecting and exploring these labyrinthine changes in further detail.
EEG Signal Processing to Control a Finger Rehabilitation System
Authors: FallahTaherpazir Mahdi , Menhaj Mohammadbagher , Sajedin Atena 
Published: July 2023

AbstractThis study aims to provide a comprehensive comparison for classification of Electroencephalography (EEG) signal based motor imagery, in time domain and time-frequency domain with different classifiers. We used EEG signals recorded while the subjects were imagining the movement of individual fingers, and analyzed the signals in time domain as well as using wavelet transform and Wigner transform. Our main goal is to compare different methods of feature extraction and classification as the important steps in the process of EEG signals for the Brain-Computer Interface (BCI) system. The experimental results indicate that the Support Vector Machine (SVM) method provides a better classification performance compared with other classification methods. Also, Linear Discriminative Analysis (LDA) performs as well as the SVM, after applying PCA for dimension reduction. The proposed scheme can be applied successfully to BCI systems where the amount of large data.
Effect of natural precursors and micro/macroparticles addition on the morphology modulation ofStreptomyces toxytriciniKD18 stimulates lipstatin productivity
Authors:   Khushboo, Dhaka Namrata , Dubey Kashyap Kumar 
Published: July 2023

AbstractThe cellular architecture of filamentous microbes is of great interest because it is frequently associated with secondary metabolite productivity and can be altered by cultivation conditions. Hence, the evaluation of cell morphology is of the utmost significance for better understanding of industrial processes involving filamentous bacteria. In the present study, effect of glass beads and silica particle addition have been seen in the enhancement of lipstatin production along with alterations in the morphology. The addition of glass beads and silica particles directed the morphology ofStreptomyces toxytriciniKD18 towards the formation of small pellets (0.3 to 0.4mm) with dispersed mycelia as compared to the control conditions (0.04 to 2mm). A four-fold increase in lipstatin production was achieved due to mechanical stress caused by glass beads and silica particles. The addition of natural precursors, i.e.,Aloe verapulp,Hibiscus cannabinusleaves and flowers improved the production of lipstatin from 2.06 mg/ml to 6.76 mg/ml, 11.4 mg/ml and 14.09 mg/ml, respectively along with alteration in the pellet morphology in 500 ml shake flask.
Long-read sequencing shows complex structural variants in tumor-stage mycosis fungoides
Authors: Hain Carsten , Stadler Rudolf , Kalinowski Jörn 
Published: July 2023

AbstractMycosis fungoides is the most common cutaneous T-cell lymphoma. Recurrent copy-number variations are the main unifying mutations in this disease, but to date, a comprehensive analysis of occurrence and type of structural variants responsible for these copy-number variations remains elusive. In this study, we used Oxford Nanopore Technologies long-read sequencing to elucidate the highly rearranged genomic landscape of five mycosis fungoides samples. We show the occurrence of multiple classes of simple and complex SV and analyze the extend of tumor suppressor gene deletion by complex SVs. Furthermore, leveraging long-read data, we inferred the genomic structure of a chromothripsis event. Our findings highlight the potential of long-read sequencing as a powerful tool for comprehensive genomic analysis in mycosis fungoides.
ANGPTL8 R59W variant influences inflammation through modulating NF-κB pathway under TNFα stimulation
Authors: Abu-Farha Mohamed , Madhu Dhanya , Hebbar Prashantha , Mohammad Anwar , Channanath Arshad , Kavalakatt Sina , Alam-Eldin Nada , Alterki Fatima , Taher Ibrahem , Alsmadi Osama , Shehab Mohammad , Arefanian Hossein , Ahmad Rasheed , Al-Mulla Fahd , Thanaraj Thangavel Alphonse , Abubaker Jehad 
Published: July 2023

AbstractBackgroundANGPTL8 is known to regulate lipid metabolism and inflammation. It interacts with ANGPTL3 and ANGPTL4 to regulate LPL activity, and with IKKα/β to modulate NF-κB activity. Further, a SNP leading to ANGPTL8 R59W variant associates with reduced LDL/HDL and increased FBG in Hispanic and Arab individuals, respectively. In this study, we investigate the impact of R59W variant on the inflammatory activity of ANGPTL8.MethodsANGPTL8 R59W variant was genotyped in a discovery cohort of 867 Arab individuals from Kuwait. Plasma levels of ANGPTL8 and inflammatory markers were measured and tested for associations with the genotype; the associations were tested for replication in an independent cohort of 278 Arab individuals. Impact of the ANGPTL8 R59W variant on NF-κB activity was examined using approaches including overexpression, luciferase assay, and structural modeling of binding dynamics.ResultsThe ANGPTL8 R59W variant was associated with increased circulatory levels of TNFα and IL7. NF-κB activity, as assessed by the increased in the phosphorylation of IKK-α/β protein, IκBα, and NF-κB p-65 in R59W variant compared to wild type, and TNFα stimulation further elevated it. This finding was substantiated by increased luciferase activity of NF-κB p65 with the R59W variant. Modeled structural and binding variation due to R59W change in ANGPTL8 agreed with the observed increase in NF-κB activity.ConclusionANGPTL8 R59W is associated with increased circulatory TNFα, IL7 and NF-κB p65 activity. Weak transient binding of ANGPTL8 R59W variant explains its regulatory role on the NF-κB pathway and inflammation.
Parafoveal vision reveals qualitative differences between FFA and PPA
Authors: Kreichman Olga , Gilaie-Dotan Sharon 
Published: July 2023

AbstractThe center-periphery visual field axis guides early visual system organization with enhanced resources devoted to central vision leading to reduced peripheral performance relative to that of central vision (i.e., behavioral eccentricity effect) for most visual functions. The center-periphery organization extends to high-order visual cortex where for example the well-studied face-sensitive fusiform face area (FFA) shows sensitivity to central vision and place-sensitive parahippocampal place area (PPA) shows sensitivity to peripheral vision. As we have recently found that face perception is more sensitive to eccentricity than place perception, here we examined whether these behavioral findings reflect differences in FFA and PPA’s sensitivities to eccentricity. We assumed FFA would show higher sensitivity to eccentricity than PPA would, but that both regions’ modulation by eccentricity would be invariant to the viewed category. We parametrically investigated (fMRI, n=32) how FFA’s and PPA’s activations are modulated by eccentricity (≤8°) and category (upright/inverted faces/houses) while keeping stimulus size constant. As expected, FFA showed an overall higher sensitivity to eccentricity than PPA. However, both regions’ activation modulations by eccentricity were dependent on the viewed category. In FFA a reduction of activation with growing eccentricity (“BOLD eccentricity effect”) was found (with different amplitudes) for all categories. In PPA however, there were qualitative modulations of the BOLD eccentricity effect with mild BOLD eccentricity effect for houses but a reverse BOLD eccentricity effect for faces and no modulation for inverted faces. Our results emphasize that peripheral vision investigations are critical to further our understanding of visual processing both quantitatively and qualitatively.Significance statementVisual perception significantly deteriorates with growing distance from central vision (behavioral eccentricity effect) with varying degrees according to visual function. For some functions (but not others) deterioration follows the reduction of resources devoted to peripheral vision at early visual processing stages. While early stages of visual processing reflect retinal spatial arrangement, here we found that activations in high-order visual areas that are less sensitive to visual field location show a BOLD fMRI activation eccentricity effect that mirrors the behavioral eccentricity effect. Importantly, the BOLD eccentricity effects we found varied across regions and were modulated quantitatively and qualitatively by the viewed visual categories. Our results emphasize that peripheral vision investigations are critical to further our understanding of visual processing.
Unveiling drug tolerant and persister-like cells inLeishmania braziliensislines derived from patients with cutaneous leishmaniasis
Authors: Jara Marlene , Arevalo Jorge , Llanos Alejandro , Van den Broeck Frederik , Domagalska Malgorzata Anna , Dujardin Jean Claude 
Published: July 2023

AbstractIntroductionResistance against anti-Leishmaniadrugs (DR) has been studied for years, giving important insights into long-term adaptations of these parasites to drugs, through genetic modifications. However, microorganisms can also survive lethal drug exposure by entering into temporary quiescence, a phenomenon called drug tolerance (DT), which is rather unexplored inLeishmania.MethodsWe studied a panel of 9Leishmania braziliensisstrains highly susceptible to potassium antimonyl tartrate (PAT), exposed promastigotes to lethal PAT pressure and compared several cellular and molecular parameters distinguishing DT from DR.Results and discussionWe demonstratedin vitrothat a variable proportion of cells remained viable, showing all the criteria of DT and not of DR: (i) signatures of quiescence, under drug pressure: reduced proliferation and significant decrease of rDNA transcription, (ii) reversibility of the phenotype: return to low IC50after removal of drug pressure, (iii) absence of significant genetic differences between exposed and unexposed lineages of each strain and absence of reported markers of DR. We found different levels of quiescence and DT among the differentL. braziliensisstrains. We provide here a newin vitromodel of drug-induced quiescence and DT inLeishmania. Research should be extendedin vivo, but current model could be further exploited to support R&D, for instance, to guide screening of compounds able to overcome quiescence resilience of the parasite, hereby improving therapy of leishmaniasis.
Examining the impact of cultural values on the adoption of big data analytics in healthcare organizations
Authors: Alzaabi Hind Mubarak , Alawadhi Mohamed Abdulla , Ahmad Syed Zamberi 
Published: July 2023

Purpose
This study aims to examine the impact of cultural values [power distance (PD), uncertainty avoidance (UC), individualism vs collectivism (IC) and time orientation] and users’ perceptions on the adoption of big data analytics (BDA) within the context of the United Arab Emirates (UAE) health-care sector. It uses the unified theory of acceptance and use of technology (UTAUT) model as its theoretical foundation.

Design/methodology/approach
A cross-sectional survey involving 256 health-care organization users in major hospitals across the UAE was conducted. Smart partial least squares (PLS) structural equation modeling was used to assess users’ behavioral intentions (BI) to use BDA in the health-care context.

Findings
Results indicate that performance expectancy, social influence, facilitating conditions and perceived trust significantly predicted respondents’ BI to use BDA. However, effort expectancy, perceived security and time orientation were found to have insignificant impacts on BI. Interestingly, the remaining cultural values (PD, UC and IC) did not significantly affect the relationship between social influence and BI in the context of BDA adoption in health care.

Originality/value
This study contributes to the literature by examining the role of cultural dimensions in BDA adoption within health-care organizations, particularly in the underrepresented UAE health-care context. Moreover, it extends the application of the UTAUT model to the BDA adoption in health care, providing insights into the factors affecting users’ BIs to use the technology.
Organizational resistance through organizing principles: the case of gender equality in the military
Authors: Holmberg Arita , Alvinius Aida 
Published: July 2023

Purpose
Previous studies show that the implementation of gender equality encounters resistance in military organizations, but it is often invisible or seen as confined to anonymous structures or troubled individuals. This paper aims to show how the Swedish Armed Forces (SAF) use organizational principles to resist implementing gender equality measures.

Design/methodology/approach
The study is a qualitative analysis of discursive strategies in the SAF’s 2013–2018 annual reports to government.

Findings
The organizing principles of instrumentality and distance, while existing in parallel with gender equality efforts, actually pursue logics that prevents the SAF from implementing gender equality. The principle of instrumentality in this context means that gender equality in the SAF is of secondary interest to organizational members. The principle of distancing from the problem includes strategies that alienate female from male officers.

Originality/value
The contribution of this paper is the finding that the use of organizing principles represents conscious organizational resistance to gender equality efforts. This kind of use needs to be revealed and criticized to change military organizations.
Thinking styles of Australasian paramedics and paramedicine students
Authors: Keene Toby , Pammer Kristen , Newman Eryn , Lord Bill 
Published: July 2023

Purpose Paramedics play important roles in healthcare, yet little is known about their decision-making. There is evidence that thinking style is associated with individual preference for intuitive or deliberative decision-making.Design/methodology/approach Australian and New Zealand paramedics (n = 103; mean age: 38.7; mean 12 years’ experience; 44% female) and paramedic students (n = 101; mean age: 25.7; 59% female) completed a thinking style survey measuring active open-mindedness (AOT), close mindedness (CMT), preference for intuitive thinking (PIT) and preference for effortful thinking (PET). Participants also completed the 7-item Cognitive Reflection Test (CRT) to assess ability to override an attractive but incorrect intuition.Findings With prior exposure to the CRT controlled, regression analysis found increasing AOT and decreasing age predicted cognitive reflection across all participants (R2/R2 adjusted: 0.198/0.157; F(10, 192) = 4.752, p < 0.001). There were moderate correlations between CMT, age and paramedic experience. There was no difference between paramedics and student performance on the CRT, though more students reported prior exposure to the items (33.7 vs 16.5%; Chi-square (2) = 8.02, p = 0.02). Those who reported prior exposure to the CRT scored significantly higher than those who had not (5.08 [1.44] vs 3.87 [1.70]; F(2, 201) = 14.34, p < 0.001).Originality/value Self-reported AOT was associated with cognitive reflection and indicates a role for open-mindedness in paramedics to support decision-making.
Incorporating user behavior flow for user risk assessment
Authors: Shan Yuxiang , Ren Qin , Yu Gang , Li Tiantian , Cao Bin 
Published: July 2023

Purpose
Internet marketing underground industry users refer to people who use technology means to simulate a large number of real consumer behaviors to obtain marketing activities rewards illegally, which leads to increased cost of enterprises and reduced effect of marketing. Therefore, this paper aims to construct a user risk assessment model to identify potential underground industry users to protect the interests of real consumers and reduce the marketing costs of enterprises.

Design/methodology/approach
Method feature extraction is based on two aspects. The first aspect is based on traditional statistical characteristics, using density-based spatial clustering of applications with noise clustering method to obtain user-dense regions. According to the total number of users in the region, the corresponding risk level of the receiving address is assigned. So that high-quality address information can be extracted. The second aspect is based on the time period during which users participate in activities, using frequent item set mining to find multiple users with similar operations within the same time period. Extract the behavior flow chart according to the user participation, so that the model can mine the deep relationship between the participating behavior and the underground industry users.

Findings
Based on the real underground industry user data set, the features of the data set are extracted by the proposed method. The features are experimentally verified by different models such as random forest, fully-connected layer network, SVM and XGBOST, and the proposed method is comprehensively evaluated. Experimental results show that in the best case, our method can improve the F1-score of traditional models by 55.37%.

Originality/value
This paper investigates the relative importance of static information and dynamic behavior characteristics of users in predicting underground industry users, and whether the absence of features of these categories affects the prediction results. This investigation can go a long way in aiding further research on this subject and found the features which improved the accuracy of predicting underground industry users.