bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access to Water‐Related Services Strongly Modulates Human Development
Authors: Amorocho‐Daza H. , van der Zaag P. , Sušnik J. 
Published: April 2023

AbstractWater enables health, education, and economic well‐being opportunities for humanity. Access to basic water and sanitation services, freshwater variability, and water storage are some of the dimensions that may impact on human development worldwide. Yet few studies quantitatively explore the relationship between water and human development. This study uses a statistical approach to quantify the Water‐Human Development relation in a global sample, both in terms of correlation and causality between variables. Correlation is established using a multiple linear regression approach, while causality is explored by implementing the multi‐spatial convergent cross mapping technique. Our study finds strong interdependence between water‐related variables and human development globally. Access to water services positively influences the Human Development Index (HDI), seasonal variability of freshwater resources restricts it, and large water storage is not significant. The analysis is robust between 2000 and 2017, and implies that a 1% increment in a country's HDI is associated with a 1.3%–3.2% increment in water and sanitation access. Causal analyses show strong coupling, suggesting positive feedback between access to water services and HDI that could be exploited. Reaching Sustainable Development Goal 6 requires closing the water and sanitation access gaps while addressing freshwater variability challenges. This will result in global human development benefits.
The Role of On‐ and Off‐Axis Faults and Fissures During Eruption Cycles and Crustal Accretion at 9°50′N, East Pacific Rise
Authors: Wu Jyun‐Nai , Parnell‐Turner Ross , Fornari Daniel J. , Berrios‐Rivera Natalia , Barreyre Thibaut , McDermott Jill M. 
Published: April 2023

AbstractFissures and faults provide insight into how plate separation is accommodated by magmatism and brittle deformation during crustal accretion. Although fissure and fault geometry can be used to quantify the spreading process at mid‐ocean ridges, accurate measurements are rare due to insufficiently detailed mapping data. Here, fissures and faults at the fast‐spreading 9°50′N segment of the East Pacific Rise were mapped using bathymetric data collected at 1‐m horizontal resolution by autonomous underwater vehicle Sentry. Fault dip estimates from the bathymetric data were calibrated using co‐registered near‐bottom imagery and depth transects acquired by remotely operated vehicle Jason. Fissures are classified as either eruptive or non‐eruptive (i.e., cracks). Tectonic strain estimated from corrected fault heaves suggests that faulting plays a negligible role in the plate separation on crust younger than 72 kyr (<4 km from the ridge axis). Pre‐ and post‐eruption surveys show that most fissures were reactivated during the eruptions in 2005–2006. Variable eruptive fissure geometry could be explained by the frequency with which each fissure is reactivated and partially infilled. Fissure swarms and lava plateaus in low‐relief areas >2 km from the ridge are spatially associated with off‐axis lower‐crustal magma lenses identified in multichannel seismic data. Deep, closely spaced fissures overlie a relatively shallow portion of the axial magma lens. The width of on‐axis fissures and inferred subsurface dike geometry imply a ∼9‐year long diking recurrence interval to fully accommodate plate spreading, which is broadly consistent with cycle intervals obtained from estimates of melt extraction rates, eruption volumes, and spreading rate.
Volcano Opto‐Acoustics: Mapping the Infrasound Wavefield at Yasur Volcano (Vanuatu)
Authors: Johnson J. B. , Boyer T. , Watson L. M. , Anderson J. F. 
Published: April 2023

AbstractWe explore the capabilities of volcano opto‐acoustics, a promising technique for measuring explosion and infrasound resonance phenomena at open‐vent volcanoes. Joint visual and infrasound study at Yasur Volcano (Vanuatu) demonstrate that even consumer‐grade cameras are capable of recording infrasound with high fidelity. Passage of infrasonic waves, ranging from as low as 5 Pa to hundreds of Pa, from both explosions and persistent tremor, pressurizes and depressurizes ambient plumes inducing visible vaporization and condensation respectively. Optical tracking of these pressure wavefields can be used to identify spectral characteristics, which vary within Yasur's two deep craters and are distinct for explosion and tremor sources. Wavefield maps can illuminate the propagation of blasts as well as the dynamics of persistent infrasonic tremor associated with standing waves in the craters. We propose that opto‐acoustic monitoring is useful for extraction of near‐vent infrasound signal and for tracking volcanic unrest from a remote distance.
Simulating the Upper Hybrid Instability as a Cause for 150 km Echoes
Authors: Green A. , Oppenheim M. , Longley W. 
Published: April 2023

AbstractOne Hundred and Fifty kilometer echoes are a type of strong radar echo observed in the valley region of the equatorial ionosphere, whose origin was long standing mystery. Recently, a new upper hybrid (UH) instability theory, driven by high energy photoelectrons, has been proposed to explain most features of 150 km echoes. However, this instability excites high frequency electron modes, whereas radars observe low frequency ion modes. To explain 150 km echoes, the UH instability must ultimately excite ion acoustic modes. This paper describes a set of particle‐in‐cell simulations used to study how photoelectrons interacting with a cold background plasma generate UH waves, and how these drive ion acoustic waves measured by radars. We implement a new electron‐N2 collision algorithm to better model the bump on tail features of the photoelectron distribution in the valley region. These simulations show that photoelectrons drive unstable UH waves that strongly enhance ion acoustic waves. We also show a strong frequency dependence on power in the ion line, which explains observational differences between radars, most notably the lack of echoes at ALTAIR. The photoelectron driven UH instability successfully reproduces most features of 150 km echoes associated with naturally enhanced incoherent scattering.
Breaking the Ring of Fire: How Ridge Collision, Slab Age, and Convergence Rate Narrowed and Terminated the Antarctic Continental Arc
Authors: Burton‐Johnson Alex , Bastias Joaquin , Kraus Stefan 
Published: April 2023

AbstractThe geometry of the Antarctic‐Phoenix Plate system, with the Antarctic Plate forming both the overriding plate and the conjugate to the subducting oceanic plate, allows quantification of slab age and convergence rate back to the Paleocene and direct comparison with the associated magmatic arc. New Ar‐Ar data from Cape Melville (South Shetland Islands, SSI) and collated geochronology shows Antarctic arc magmatism ceased at ∼19 Ma. Since the Cretaceous, the arc front remained ∼100 km from the trench whilst its rear migrated trenchward at 6 km/Myr. South of the SSI, arc magmatism ceased ∼8–5 Myr prior to each ridge‐trench collision, whilst on the SSI (where no collision occurred) the end of arc magmatism predates the end of subduction by ∼16 Myr. Despite the narrowing and successive cessation of the arc, geochemical and dyke orientation data shows the arc remained in a consistently transitional state of compressional continental arc and extensional backarc tectonics. Numerically relating slab age, convergence rate, and slab dip to the Antarctic‐Phoenix Plate system, we conclude that the narrowing of the arc and the cessation of magmatism south of the SSI was primarily in response to the subduction of progressively younger oceanic crust, and secondarily to the decreasing convergence rate. Increased slab dip beneath the SSI migrated the final magmatism offshore. Comparable changes in the geometry and composition are observed on the Andean arc, suggesting slab age and convergence rate may affect magmatic arc geometry and composition in settings currently attributed to slab dip variation.
Revisiting Biophysical Impacts of Greening on Precipitation Over the Loess Plateau of China Using WRF With Water Vapor Tracers
Authors: Liu Yu , Ge Jun , Guo Weidong , Cao Yipeng , Chen Chaorong , Luo Xing , Yang Limei , Wang Shiyao 
Published: April 2023

AbstractThe Loess Plateau of China has witnessed a remarkable greening trend due to vegetation restoration in recent decades. However, the precipitation response to greening remains unclear, and the hydrological effect of greening is controversial. Here, we revisited biophysical effects of greening on precipitation over the plateau during 2002–2015 using the state‐of‐the‐art water vapor tracer embedded in a regional coupled model. We find that greening can promote the growing season precipitation (0.45 mm·day−1), with 15% and 85% of the precipitation increment resulting from increases in the local evapotranspiration and the water vapor inflow from outside the plateau, respectively. As a consequence, the enhanced precipitation can compensate for the terrestrial water loss driven by the increased evapotranspiration, leading to a slight increase in the water yield. This study highlights the dominant role of the nonlocal effect in precipitation responses to greening in this region.
The Impacts of a Weakened Atlantic Meridional Overturning Circulation on ENSO in a Warmer Climate
Authors: Liu Wei , Duarte Cavalcante Pinto David , Fedorov Alexey , Zhu Jiang 
Published: April 2023

AbstractThis study quantifies the impacts of the Atlantic Meridional Overturning Circulation (AMOC) on the El Niño–Southern Oscillation (ENSO) under anthropogenic warming by comparing climate change model simulations with declining and fixed strengths of the overturning. After the 1980s, a weakened AMOC is shown to reduce the strength of the annual cycle of sea surface temperature (SST) in the eastern equatorial Pacific and induce anomalous cross‐equatorial northerly winds there, which strengthens ENSO variability by about 11%. An analysis of the Bjerknes stability index reveals that this intensification of ENSO results mainly from enhanced Ekman upwelling feedback due to amplified atmospheric wind response to SST anomalies and oceanic upwelling response to equatorial wind stress anomalies. The weakened AMOC also promotes the occurrence of Central Pacific El Niño events and reduces ENSO skewness. These AMOC impacts on ENSO magnitude and complexity throughout the twenty‐first century are however smaller than ENSO variations expected from internal climate variability.
Far-infrared transparent conductors
Authors: Hu Chaoquan , Zhou Zijian , Zhang Xiaoyu , Guo Kaiyu , Cui Can , Li Yuankai , Gu Zhiqing , Zhang Wei , Shen Liang , Zhu Jiaqi 
Published: April 2023

AbstractThe long-standing challenge in designing far-infrared transparent conductors (FIRTC) is the combination of high plasma absorption edge (λp) and high conductivity (σ). These competing requirements are commonly met by tuning carrier concentration or/and effective carrier mass in a metal oxide/oxonate with low optical dielectric constant (εopt = 2–7). However, despite the high σ, the transparent band is limited to mid-infrared (λp < 5 μm). In this paper, we break the trade-off between high σ and λp by increasing the “so-called constant” εopt that has been neglected, and successfully develop the material family of FIRTC with εopt > 15 and λp > 15 μm. These FIRTC crystals are mainly octahedrally-coordinated heavy-metal chalcogenides and their solid solutions with shallow-level defects. Their high εopt relies on the formation of electron-deficiency multicenter bonds resulting in the great electron-polarization effect. The new FIRTC enables us to develop the first “continuous film” type far-infrared electromagnetic shielder that is unattainable using traditional materials. Therefore, this study may inaugurate a new era in far-infrared optoelectronics.
Cuticle supplementation and nitrogen recycling by a dual bacterial symbiosis in a family of xylophagous beetles
Authors: Kiefer Julian Simon Thilo , Bauer Eugen , Okude Genta , Fukatsu Takema , Kaltenpoth Martin , Engl Tobias 
Published: April 2023

Abstract
Many insects engage in stable nutritional symbioses with bacteria that supplement limiting essential nutrients to their host. While several plant sap-feeding Hemipteran lineages are known to be simultaneously associated with two or more endosymbionts with complementary biosynthetic pathways to synthesize amino acids or vitamins, such co-obligate symbioses have not been functionally characterized in other insect orders. Here, we report on the characterization of a dual co-obligate, bacteriome-localized symbiosis in a family of xylophagous beetles using comparative genomics, fluorescence microscopy, and phylogenetic analyses. Across the beetle family Bostrichidae, most investigated species harbored the Bacteroidota symbiont Shikimatogenerans bostrichidophilus that encodes the shikimate pathway to produce tyrosine precursors in its severely reduced genome, likely supplementing the beetles’ cuticle biosynthesis, sclerotisation, and melanisation. One clade of Bostrichid beetles additionally housed the co-obligate symbiont Bostrichicola ureolyticus that is inferred to complement the function of Shikimatogenerans by recycling urea and provisioning the essential amino acid lysine, thereby providing additional benefits on nitrogen-poor diets. Both symbionts represent ancient associations within the Bostrichidae that have subsequently experienced genome erosion and co-speciation with their hosts. While Bostrichicola was repeatedly lost, Shikimatogenerans has been retained throughout the family and exhibits a perfect pattern of co-speciation. Our results reveal that co-obligate symbioses with complementary metabolic capabilities occur beyond the well-known sap-feeding Hemiptera and highlight the importance of symbiont-mediated cuticle supplementation and nitrogen recycling for herbivorous beetles.
Effect of pharmacokinetics and pharmacogenomics in adults with allogeneic hematopoietic cell transplantation conditioned with Busulfan
Authors: Seydoux Claire , Uppugunduri Chakradhara Rao Satyanarayana , Medinger Michael , Nava Tiago , Halter Joerg , Heim Dominik , Chalandon Yves , Schanz Urs , Nair Gayathri , Cantoni Nathan , Passweg Jakob R. , Ansari Marc 
Published: April 2023

AbstractBusulfan (Bu) combined with cyclophosphamide (Cy) is commonly used as a myeloablative conditioning regimen for allogeneic hematopoietic cell transplantation (allo-HCT). There is inter-individual variability of Bu pharmacokinetics (PK) and hence in toxicity and efficacy. The introduction of therapeutic drug monitoring (TDM) of Bu has decreased toxicity of the regimen. Hepatic metabolism of Bu is mediated through Glutathione-S-Transferases (GSTs), mainly GSTA1. Patients with GSTA1*A variants are considered normal metabolizers and GSTA1*B corresponds to poor metabolism, defined by nucleotide changes at −52 or −69 locus in GSTA1 promoter region. The aim of the study was to explore the correlation between GSTA1 polymorphisms and Bu-PK in 60 adult patients receiving an allo-HCT in the BuCyBu clinical study (ClinicalTrials.gov I, ID NCT01779882) comparing the sequence BuCy to CyBu. DNA samples prior to conditioning were genotyped for candidate variants at −52 (rs3957356) and −69 (rs3957357) loci in the GSTA1 promoter. Thirty-three % of patients were GSTA1*A*A, 49% GSTA1*A*B and 18% GSTA1*B*B. In GSTA1*A*A patients, median Bu-AUC was 3.6 ± 0.7 mg*h/L, in GSTA1*A*B 4.5 ± 1.6 and in GSTA1*B*B 4.9 ± 1.4 (AUC 35% higher than GSTA1*A*A, p = 0.03), with a similar significant correlation with Bu-clearance (p = 0.04). The correlation between GSTA1 polymorphism and AUC remained significant in multivariate linear regression analysis. There was a trend for lower non-relapse mortality (NRM) in patients with low AUC. We could not demonstrate a correlation between GSTA1 polymorphisms and NRM, acute graft-versus-host disease (aGvHD) in this small cohort, but there is a trend of higher aGvHD incidence in GSTA1*B*B patients.
Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells
Authors: Lee Eun Jung , Lee Kyoung Jin , Jung Seungpil , Park Kyong Hwa , Park Serk In 
Published: April 2023

AbstractMyeloid-derived suppressor cells (MDSCs) are bone marrow (BM)-derived immunosuppressive cells in the tumor microenvironment, but the mechanism of MDSC mobilization from the BM remains unclear. We investigated how BM stromal cell activation by PTH1R contributes to MDSC mobilization. PTH1R activation by parathyroid hormone (PTH) or PTH-related peptide (PTHrP), a tumor-derived counterpart, mobilized monocytic (M-) MDSCs from murine BM without increasing immunosuppressive activity. In vitro cell-binding assays demonstrated that α4β1 integrin and vascular cell adhesion molecule (VCAM)-1, expressed on M-MDSCs and osteoblasts, respectively, are key to M-MDSC binding to osteoblasts. Upon PTH1R activation, osteoblasts express VEGF-A and IL6, leading to Src family kinase phosphorylation in M-MDSCs. Src inhibitors suppressed PTHrP-induced MDSC mobilization, and Src activation in M-MDSCs upregulated two proteases, ADAM-17 and MMP7, leading to VCAM1 shedding and subsequent disruption of M-MDSC tethering to osteoblasts. Collectively, our data provide the molecular mechanism of M-MDSC mobilization in the bones of tumor hosts.
Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like molecules
Authors: Xavier da Silva Thamara Nishida , Schulte Clemens , Alves Ariane Nunes , Maric Hans Michael , Friedmann Angeli José Pedro 
Published: April 2023

AbstractFerroptosis is a form of cell death characterized by phospholipid peroxidation, where numerous studies have suggested that the induction of ferroptosis is a therapeutic strategy to target therapy refractory cancer entities. Ferroptosis suppressor protein 1 (FSP1), an NAD(P)H-ubiquinone reductase, is a key determinant of ferroptosis vulnerability, and its pharmacological inhibition was shown to strongly sensitize cancer cells to ferroptosis. A first generation of FSP1 inhibitors, exemplified by the small molecule iFSP1, has been reported; however, the molecular mechanisms underlying inhibition have not been characterized in detail. In this study, we explore the species-specific inhibition of iFSP1 on the human isoform to gain insights into its mechanism of action. Using a combination of cellular, biochemical, and computational methods, we establish a critical contribution of a species-specific aromatic architecture that is essential for target engagement. The results described here provide valuable insights for the rational development of second-generation FSP1 inhibitors combined with a tracer for screening the druggable pocket. In addition, we pose a cautionary notice for using iFSP1 in animal models, specifically murine models.
Two assembly modes for SIN3 histone deacetylase complexes
Authors: Wang Chengcheng , Guo Zhouyan , Chu Chen , Lu Yichen , Zhang Xiaofeng , Zhan Xiechao 
Published: April 2023

AbstractThe switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play essential roles in regulating chromatin accessibility and gene expression. There are two major types of SIN3/HDAC complexes (named SIN3L and SIN3S) targeting different chromatin regions. Here we present the cryo-electron microscopy structures of the SIN3L and SIN3S complexes from Schizosaccharomyces pombe (S. pombe), revealing two distinct assembly modes. In the structure of SIN3L, each Sin3 isoform (Pst1 and Pst3) interacts with one histone deacetylase Clr6, and one WD40-containing protein Prw1, forming two lobes. These two lobes are bridged by two vertical coiled-coil domains from Sds3/Dep1 and Rxt2/Png2, respectively. In the structure of SIN3S, there is only one lobe organized by another Sin3 isoform Pst2; each of the Cph1 and Cph2 binds to an Eaf3 molecule, providing two modules for histone recognition and binding. Notably, the Pst1 Lobe in SIN3L and the Pst2 Lobe in SIN3S adopt similar conformation with their deacetylase active sites exposed to the space; however, the Pst3 Lobe in SIN3L is in a compact state with its active center buried inside and blocked. Our work reveals two classical organization mechanisms for the SIN3/HDAC complexes to achieve specific targeting and provides a framework for studying the histone deacetylase complexes.
Highly variable hearing loss due to POU4F3 (c.37del) is revealed by longitudinal, frequency specific analyses
Authors: Singh Sushma , Penney Cindy , Griffin Anne , Woodland Geoffrey , Werdyani Salem , Benteau Tammy A. , Abdelfatah Nelly , Squires Jessica , King Beverly , Houston Jim , Dyer Matthew J. , Roslin Nicole M. , Vincent Daniel , Marquis Pascale , O’Rielly Darren D. , Hodgkinson Kathy , Burt Taylor , Baker Ashley , Stanton Susan G. , Young Terry-Lynn 
Published: April 2023

AbstractGenotype-phenotype correlations add value to the management of families with hereditary hearing loss (HL), where age-related typical audiograms (ARTAs) are generated from cross-sectional regression equations and used to predict the audiogram phenotype across the lifespan. A seven-generation kindred with autosomal dominant sensorineural HL (ADSNHL) was recruited and a novel pathogenic variant in POU4F3 (c.37del) was identified by combining linkage analysis with whole exome sequencing (WES). POU4F3 is noted for large intrafamilial variation including the age of onset of HL, audiogram configuration and presence of vestibular impairment. Sequential audiograms and longitudinal analyses reveal highly variable audiogram features among POU4F3 (c.37del) carriers, limiting the utility of ARTAs for clinical prognosis and management of HL. Furthermore, a comparison of ARTAs against three previously published families (1 Israeli Jewish, 2 Dutch) reveals significant interfamilial differences, with earlier onset and slower deterioration. This is the first published report of a North American family with ADSNHL due to POU4F3, the first report of the pathogenic c.37del variant, and the first study to conduct longitudinal analysis, extending the phenotypic spectrum of DFNA15.
Anterior eye parameters and lens thickness measured by an intraoperative OCT and a swept-source OCT: comparison of hyperopic, emmetropic and myopic eyes
Authors: Müller Michael , Wortmann Charlotte , Paul Julia , Pawlowicz Katarzyna , Hemkeppler Eva , Kohnen Thomas , Böhm Myriam 
Published: April 2023

Abstract
Purpose
To evaluate if anterior chamber depth (ACD) and lens thickness (LT) measured by two different devices are affected by different eye lengths.

Methods
ACD and LT of 251 eyes (44 hyperopic, 60 myopic, 147 emmetropic) of 173 patients received with an iOCT-guided femtosecond laser-assisted lens surgery (FLACS) and the IOL Master 700 were compared.

Results
ACD measured with the IOL Master 700 was −0.026 ± 0.125 mm smaller (p = 0.001) than that with the iOCT for all eye-groups (hyperopic: p = 0.601, emmetropic: p = 0.003; myopic: p = 0.094). However, differences in all groups were not clinically relevant. LT measurements (all eyes: −0.0642 ± 0.0504 mm) shows a statistically significant difference in all evaluated groups (p < 0.001). Only myopic eyes showed a clinically relevant difference in LT.

Conclusion
The two devices show no clinically relevant differences in the eye-length groups (myopic, emmetropic, and hyperopic) for all ACD measurements. LT data shows a clinically relevant difference only for the group of myopic eyes.