bluuebunny/crossref_metadata_2025_split huggingface dataset:
CO-RADS score and its correlation with clinical and laboratory parameters in patients with COVID-19
Authors: Elnaggar Marwa Elsayed , Rawy Abeer Mohamed , El-Melouk Marwa Seif , Al-Tabbakh Al-Shaimaa Mahmoud , Abdel-Khalik Hamasat Abdel-hafeez , Abdelkhalek Eman Fathy , Elsawy Rehab Elsayed 
Published: January 2023

Abstract
Background
Polymerase chain reaction (PCR) based SARS-CoV-2 RNA detection and serological antibody tests give a proof of Coronavirus Disease 2019 (COVID-19) infection. Several variables can influence the consequences of these tests. Inflammatory markers among mild and severe patients of COVID-19 showed dissimilarity in inflammatory markers while computed tomography (CT) in patients infected with COVID-19 used to evaluate infection severity. The aim of this study is to investigate the application of the COVID-19 Reporting and Data System (CO-RADS) classification in COVID-19 patients and its relation to clinical and laboratory finding.

Results
One hundred patients suspected to have COVID-19 infection were involved. Their age was 49.6 ± 14.7. Fever and cough were the frequent presenting symptoms. Patients with positive PCR were significantly associated with dyspnea and higher inflammatory markers. Lymphopenia had sensitivity of 63.6% and specificity of 91.7%. Combination of PCR and lymphopenia increased both sensitivity and specificity. CT findings in relation to PCR showed sensitivity of 90.5% and specificity of 25%. CO-RADS score showed positive correlation with age and inflammatory biomarkers and negative correlation with absolute lymphocyte count (ALC).

Conclusions
CT finding was more prominent in older patients with COVID-19 and associated with higher inflammatory biomarkers and lower ALC which were correlated with CO-RADS score. Patients with positive PCR had more symptoms and inflammatory marker. Combination of PCR with either lymphopenia or CT finding had more sensitivity, specificity and accuracy in diagnosis
The impact of patient involvement on participant opinions of information sheets
Authors: Hudson Georgie , Jansli Sonja M. , Morris Daniel , Wykes Til , Jilka Sagar 
Published: January 2023

Background
Patient and public involvement (PPI) groups can provide valuable input to create more accessible study documents with less jargon. However, we don't know whether this procedure improves accessibility for potential participants.

Aims
We assessed whether participant information sheets were rated as more accessible after PPI review and which aspects of information sheets and study design were important to mental health patients compared with a control group with no mental health service use.

Method
This was a double-blind quasi-experimental study using a mixed-methods explanatory design. Patients and control participants quantitatively rated pre- and post-review documents. Semi-structured interviews were thematically analysed to gain qualitative feedback on opinions of information sheets and studies. Two-way multivariate analysis of variance was used to detect differences in ratings between pre- and post-review documents.

Results
We found no significant (P < 0.05) improvements in patient (n = 15) or control group (n = 21) ratings after PPI review. Patients and controls both rated PPI as of low importance in studies and considered the study rationale as most important. However, PPI was often misunderstood, with participants believing that it meant lay patients would take over the design and administration of the study. Qualitative findings highlight the importance of clear, friendly and visually appealing information sheets.

Conclusions
Researchers should be aware of what participants want to know about so they can create information sheets addressing these priorities, for example, explaining why the research is necessary. PPI is poorly understood by the wider population and efforts must be made to increase diversity in participation.
Assessment of beliefs and attitudes about electroconvulsive therapy posted on Twitter: An observational study
Authors: de Anta L. , Alvarez-Mon M. A. , Donat-Vargas C. , Lara-Abelanda F. J. , Pereira-Sanchez V. , Gonzalez Rodriguez C. , Mora F. , Ortega M. A. , Quintero J. , Alvarez-Mon M. 
Published: January 2023

Abstract

Background
Electroconvulsive therapy (ECT) is an effective and safe medical procedure that mainly indicated for depression, but is also indicated for patients with other conditions. However, ECT is among the most stigmatized and controversial treatments in medicine. Our objective was to examine social media contents on Twitter related to ECT to identify and evaluate public views on the matter.

Methods
We collected Twitter posts in English and Spanish mentioning ECT between January 1, 2019 and October 31, 2020. Identified tweets were subject to a mixed method quantitative–qualitative content and sentiment analysis combining manual and semi-supervised natural language processing machine-learning analyses. Such analyses identified the distribution of tweets, their public interest (retweets and likes per tweet), and sentiment for the observed different categories of Twitter users and contents.

Results
“Healthcare providers” users produced more tweets (25%) than “people with lived experience” and their “relatives” (including family members and close friends or acquaintances) (10% combined), and were the main publishers of “medical” content (mostly related to ECT’s main indications). However, more than half of the total tweets had “joke or trivializing” contents, and such had a higher like and retweet ratio. Among those tweets manifesting personal opinions on ECT, around 75% of them had a negative sentiment.

Conclusions
Mixed method analysis of social media contents on Twitter offers a novel perspective to examine public opinion on ECT, and our results show attitudes more negative than those reflected in studies using surveys and other traditional methods.
Advancing Survivors Knowledge (ASK Study) of Skin Cancer Surveillance After Childhood Cancer: A Randomized Controlled Trial in the Childhood Cancer Survivor Study
Authors: Geller Alan C. , Coroiu Adina , Keske Robyn R. , Haneuse Sebastien , Davine Jessica A. , Emmons Karen M. , Daniel Casey L. , Gibson Todd M. , McDonald Aaron J. , Robison Leslie L. , Mertens Ann C. , Elkin Elena B. , Marghoob Ashfaq , Armstrong Gregory T. 
Published: January 2023

PURPOSETo improve skin cancer screening among survivors of childhood cancer treated with radiotherapy where skin cancers make up 58% of all subsequent neoplasms. Less than 30% of survivors currently complete recommended skin cancer screening.PATIENTS AND METHODSThis randomized controlled comparative effectiveness trial evaluated patient and provider activation (PAE + MD) and patient and provider activation with teledermoscopy (PAE + MD + TD) compared with patient activation alone (PAE), which included print materials, text messaging, and a website on skin cancer risk factors and screening behaviors. Seven hundred twenty-eight participants from the Childhood Cancer Survivor Study (median age at baseline 44 years), age > 18 years, treated with radiotherapy as children, and without previous history of skin cancer were randomly assigned (1:1:1). Primary outcomes included receiving a physician skin examination at 12 months and conducting a skin self-examination at 18 months after intervention.RESULTSRates of physician skin examinations increased significantly from baseline to 12 months in all three intervention groups: PAE, 24%-39%, relative risk [RR], 1.65, 95% CI, 1.32 to 2.08; PAE + MD, 24% to 39%, RR, 1.56, 95% CI, 1.25 to 1.97; PAE + MD + TD, 24% to 46%, RR, 1.89, 95% CI, 1.51 to 2.37. The increase in rates did not differ between groups ( P = .49). Similarly, rates of skin self-examinations increased significantly from baseline to 18 months in all three groups: PAE, 29% to 50%, RR, 1.75, 95% CI, 1.42 to 2.16; PAE + MD, 31% to 58%, RR, 1.85, 95% CI, 1.52 to 2.26; PAE + MD + TD, 29% to 58%, RR, 1.95, 95% CI, 1.59 to 2.40, but the increase in rates did not differ between groups ( P = .43).CONCLUSIONAlthough skin cancer screening rates increased more than 1.5-fold in each of the intervention groups, there were no differences between groups. Any of these interventions, if implemented, could improve skin cancer prevention behaviors among childhood cancer survivors.
Neoadjuvant Pembrolizumab in Localized Microsatellite Instability High/Deficient Mismatch Repair Solid Tumors
Authors: Ludford Kaysia , Ho Won Jin , Thomas Jane V. , Raghav Kanwal P.S. , Murphy Mariela Blum , Fleming Nicole D. , Lee Michael S. , Smaglo Brandon G. , You Y. Nancy , Tillman Matthew M. , Kamiya-Matsuoka Carlos , Thirumurthi Selvi , Messick Craig , Johnson Benny , Vilar Eduardo , Dasari Arvind , Shin Sarah , Hernandez Alexei , Yuan Xuan , Yang Hongqui , Foo Wai Chin , Qiao Wei , Maru Dipen , Kopetz Scott , Overman Michael J. 
Published: January 2023

PURPOSE Pembrolizumab significantly improves clinical outcomes in advanced/metastatic microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) solid tumors but is not well studied in the neoadjuvant space. METHODS This is a phase II open-label, single-center trial of localized unresectable or high-risk resectable MSI-H/dMMR tumors. Treatment is pembrolizumab 200 mg once every 3 weeks for 6 months followed by surgical resection with an option to continue therapy for 1 year followed by observation. To continue on study, patients are required to have radiographic or clinical benefit. The coprimary end points are safety and pathologic complete response. Key secondary end points are response rate and organ-sparing at one year for patients who declined surgery. Exploratory analyses include interrogation of the tumor immune microenvironment using imaging mass cytometry. RESULTS A total of 35 patients were enrolled, including 27 patients with colorectal cancer and eight patients with noncolorectal cancer. Among 33 evaluable patients, best overall response rate was 82%. Among 17 (49%) patients who underwent surgery, the pathologic complete response rate was 65%. Ten patients elected to receive one year of pembrolizumab followed by surveillance without surgical resection (median follow-up of 23 weeks [range, 0-54 weeks]). An additional eight did not undergo surgical resection and received less than 1 year of pembrolizumab. During the study course of the trial and subsequent follow-up, progression events were seen in six patients (four of whom underwent salvage surgery). There were no new safety signals. Spatial immune profiling with imaging mass cytometry noted a significantly closer proximity between granulocytic cells and cytotoxic T cells in patients with progressive events compared with those without progression. CONCLUSION Neoadjuvant pembrolizumab in dMMR/MSI-H cancers is safe and resulted in high rates of pathologic, radiographic, and endoscopic response, which has implications for organ-sparing strategies.
Internet-Based Germline Genetic Testing for Men With Metastatic Prostate Cancer
Authors: Cheng Heather H. , Sokolova Alexandra O. , Gulati Roman , Bowen Deborah , Knerr Sarah A. , Klemfuss Nola , Grivas Petros , Hsieh Andrew C. , Lee John K. , Schweizer Michael T. , Yezefski Todd , Zhou Alicia , Yu Evan Y. , Nelson Peter S. , Montgomery Bruce 
Published: January 2023

PURPOSE Germline mutations in DNA repair genes are present in approximately 10% of men with metastatic prostate cancer (mPC), and guidelines recommend genetic germline testing. Notable barriers exist, including access to genetic counseling, insurance coverage, and out-of-pocket costs. The GENTleMEN study was designed to determine the feasibility of an Internet-based, patient-driven germline genetic testing approach for men with mPC. PATIENTS AND METHODS In this prospective cohort study, men with mPC provided informed consent via an Internet-based platform and completed a questionnaire including demographics and family cancer history. Supporting medical data were also collected. Genetic testing was performed using the Color Genomics 30-gene targeted panel of cancer predisposition genes on a mailed saliva sample. Men whose test results identified a germline pathogenic or likely pathogenic variant received results by phone or telehealth genetic counseling; other participants received results by email with an option for phone-based or telehealth genetic counseling. RESULTS As of August 18, 2021, 816 eligible men were consented, of whom 68% (551) completed genetic testing, and 8.7% (48 of 551) were found to carry a pathogenic or likely pathogenic variant in a germline DNA repair gene: CHEK2 (17), BRCA2 (15), ATM (6), NBN1 (3), BRCA1 (2), PALB2 (2), PMS2 (2), and MSH6 (1). Participants were more likely to complete the testing process if they were non-Hispanic White, married, highly educated, or from a higher-income bracket. CONCLUSION Here, we show the feasibility of delivering germline (inherited) genetic testing by a voluntary, patient-driven, Internet-based platform to men with mPC. Preliminary results show rates of germline DNA repair mutations, consistent with other cohorts. Although feasible for some, reduced steps for participation, more dedicated diverse outreach and participant support, and identification and addressing of additional barriers is needed to ensure equitable access and optimization.
Energy Expenditure Under General Anesthesia: An Observational Study Using Indirect Calorimetry in Patients Having Noncardiac Surgery
Authors: Briesenick Luisa , Schaade Annika , Bergholz Alina , Hoppe Phillip , Kouz Karim , Krause Linda , Flick Moritz , Saugel Bernd 
Published: January 2023

BACKGROUND:
Perioperative hemodynamic management aims to optimize organ perfusion pressure and blood flow—assuming this ensures that oxygen delivery meets cellular metabolic needs. Cellular metabolic needs are reflected by energy expenditure. A better understanding of energy expenditure under general anesthesia could help tailor perioperative hemodynamic management to actual demands. We thus sought to assess energy expenditure under general anesthesia. Our primary hypothesis was that energy expenditure under general anesthesia is lower than preoperative awake resting energy expenditure.

METHODS:
We conducted an observational study on patients having elective noncardiac surgery at the University Medical Center Hamburg-Eppendorf (Germany) between September 2019 and March 2020. We assessed preoperative awake resting energy expenditure, energy expenditure under general anesthesia, and energy expenditure after surgery using indirect calorimetry. We compared energy expenditure under general anesthesia at incision to preoperative awake resting energy expenditure using a Wilcoxon signed-rank test for paired measurements.

RESULTS:
We analyzed 60 patients. Median (95% confidence interval [CI]) preoperative awake resting energy expenditure was 953 (95% CI, 906–962) kcal d–1 m–2. Median energy expenditure under general anesthesia was 680 (95% CI, 642–711) kcal d–1 m–2—and thus 263 (95% CI, 223–307) kcal d–1 m–2 or 27% (95% CI, 23%–30%) lower than preoperative awake resting energy expenditure (P < .001).

CONCLUSIONS:
Median energy expenditure under general anesthesia is about one-quarter lower than preoperative awake resting energy expenditure in patients having noncardiac surgery.
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells
Authors: Sluimer Lilian M. , Bullock Esme , Rätze Max A. K. , Enserink Lotte , Overbeeke Celine , Hornsveld Marten , Brunton Valerie G. , Derksen Patrick W. B. , Tavares Sandra 
Published: January 2023

ABSTRACT
High expression of the non-receptor tyrosine kinase FER is an independent prognostic factor that correlates with poor survival in breast cancer patients. To investigate whether the kinase activity of FER is essential for its oncogenic properties, we developed an ATP analogue-sensitive knock-in allele (FERASKI). Specific FER kinase inhibition in MDA-MB-231 cells reduces migration and invasion, as well as metastasis when xenografted into a mouse model of breast cancer. Using the FERASKI system, we identified Ski family transcriptional corepressor 1 (SKOR1) as a direct FER kinase substrate. SKOR1 loss phenocopies FER inhibition, leading to impaired proliferation, migration and invasion, and inhibition of breast cancer growth and metastasis formation in mice. We show that SKOR1 Y234, a candidate FER phosphorylation site, is essential for FER-dependent tumor progression. Finally, our work suggests that the SKOR1 Y234 residue promotes Smad2/3 signaling through SKOR1 binding to Smad3. Our study thus identifies SKOR1 as a mediator of FER-dependent progression of high-risk breast cancers.
A dataset about Spanish young people’s digital skills, use of technology and online platforms
Authors: Aranda Daniel , Mohammadi Leila , Blasco Mireia Montaña , Estanyol Elisenda , Fernández-de-Castro Pedro 
Published: January 2023

Background: The datafication scenario of the current communicative ecosystem poses a challenge to media and digital literacy, especially in terms of participation and civic and democratic engagement of youth. Methods: For this purpose, through a survey with a representative sample of 600 young people in Spain, between 16 and 18 years old, we observed their level of digital literacy through three variables: technical competencies, informational competencies, and critical knowledge. This dataset also collects information on the reasons why young people use digital technology such as video games, consoles, computers or mobile phones. On the other hand, we also offer information on the types of social networks or applications and the time and types of uses by youngsters of different digital technologies and social media platforms. The survey includes socio-demographic factors such as gender including (male, female, and others). Conclusions: This survey offers researchers relevant data on the digital skills of Spanish youth and on the perceptions of the use of different digital technologies. This paper also reports the main descriptive data that can be expanded by researchers accessing the database.
Femoral impingement in maximal hip flexion is anterior-inferior distal to the cam deformity in femoroacetabular impingement patients with femoral retroversion
Authors: Boschung Adam , Faulhaber Senta , Kiapour Ata , Kim Young-jo , Novais Eduardo N. , Steppacher Simon D. , Tannast Moritz , Lerch Till D. 
Published: January 2023

Aims Femoroacetabular impingement (FAI) patients report exacerbation of hip pain in deep flexion. However, the exact impingement location in deep flexion is unknown. The aim was to investigate impingement-free maximal flexion, impingement location, and if cam deformity causes hip impingement in flexion in FAI patients. Methods A retrospective study involving 24 patients (37 hips) with FAI and femoral retroversion (femoral version (FV) < 5° per Murphy method) was performed. All patients were symptomatic (mean age 28 years (SD 9)) and had anterior hip/groin pain and a positive anterior impingement test. Cam- and pincer-type subgroups were analyzed. Patients were compared to an asymptomatic control group (26 hips). All patients underwent pelvic CT scans to generate personalized CT-based 3D models and validated software for patient-specific impingement simulation (equidistant method). Results Mean impingement-free flexion of patients with mixed-type FAI (110° (SD 8°)) and patients with pincer-type FAI (112° (SD 8°)) was significantly (p < 0.001) lower compared to the control group (125° (SD 13°)). The frequency of extra-articular subspine impingement was significantly (p < 0.001) increased in patients with pincer-type FAI (57%) compared to cam-type FAI (22%) in 125° flexion. Bony impingement in maximal flexion was located anterior-inferior at femoral four and five o’clock position in patients with cam-type FAI (63% (10 of 16 hips) and 37% (6 of 10 hips)), and did not involve the cam deformity. The cam deformity did not cause impingement in maximal flexion. Conclusion Femoral impingement in maximal flexion was located anterior-inferior distal to the cam deformity. This differs to previous studies, a finding which could be important for FAI patients in order to avoid exacerbation of hip pain in deep flexion (e.g. during squats) and for hip arthroscopy (hip-preservation surgery) for planning of bone resection. Hip impingement in flexion has implications for daily activities (e.g. putting on shoes), sports, and sex. Cite this article: Bone Joint Res 2023;12(1):22–32.
Ethnobotanical study of medicinal plants used by local communities of Damot Woyde District, Wolaita Zone, Southern Ethiopia
Authors: MEGERSA MOA , WOLDETSADIK SAMUEL 
Published: January 2023

Abstract. Megersa M, Woldetsadik S. 2022. Ethnobotanical study of medicinal plants used by local communities of Damot Woyde District, Wolaita Zone, Southern Ethiopia. Nusantara Bioscience 14: 10-24. Humans have used traditional medicines mainly of plant origins to treat diseases. Early humans faced a tremendous challenge when searching for natural products used as medicines. This study reports on an ethnobotanical study that focused on the traditional medicinal plants used by local communities to treat human and livestock diseases. An ethnobotanical study on medicinal plants was conducted from February 2020 to October 2020. This involved semi-structured interviews, field observations, market surveys and group discussions with informants to document information on the use and management of medicinal plants by the people of Damot Woyde District. Fifty-seven medicinal plant species belonging to 31 families were collected, which are used by the study area inhabitants to treat various diseases in humans and livestock. The leading family was Asteraceae which was represented by 7 species (12.3%), followed by Rutaceae (6 species, 10.5%) and Solanaceae (5 species, 9%). Of the 57 medicinal plants collected, 36 (63.2%) were used to treat human ailments only, while 6 (10.5%) plant species were used to treat livestock ailments only and 15 (26.31%) were used to treat both human and livestock ailments. Herbs constituted the largest number of 22 species (38.6%), followed by shrubs 18 species (31.6%), trees 15 species (26.3%) and climbers 2 species (3.51%). Leaves (31.3%) were the most commonly used plant parts of preparing traditional remedies in the study area. Oral administration was the predominant mode of administration accounting for 71%. Preference ranking analysis revealed that Allium sativum L. was the most preferred plant species for treating the common cold. When the direct matrix ranking was analyzed, Croton macrostachyus Hochst. ex. Del. was the most commonly used medicinal plant for various purposes. Our finding revealed that plant species' use plays a vital role in treating human and animal diseases in Damot Woyde District. Phytochemical and pharmacological tests are recommended mainly on frequently used medicinal plants.