bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics of drugs used to treat drug sensitive-tuberculosis in breastfeeding mother-infant pairs: An observational pharmacokinetic study
Authors: Nakijoba Ritah , Nakayiwa Kawuma Aida , Ojara Francis Williams , Tabwenda Jovia C. , Kyeyune Jacqueline , Turyamureba Christine , Peter Asiimwe Simon , Magoola Johnson , Castelnuovo Barbara , Buzibye Allan , Waitt Catriona 
Published: May 2023

Background Globally, more than half of women take medicines whilst breastfeeding. Data concerning the exposure of the breastfed infant to drugs and any related risks are sparce. Lactation studies are only rarely performed close to licensing for medicines anticipated to be widely used in women of childbearing age. Medicines taken by breastfeeding mothers on tuberculosis (TB) treatment can be transferred to the breastfed infant. Potential effects of anti-tuberculosis medicines on nursing infants are not well understood. Potential risks are the development of adverse drug effects in the breastfed infant and selection for resistance, whereas potential benefits might include exposure to potentially prophylactic concentrations of the drug. Pharmacokinetic studies are therefore necessary to understand this situation fully. Methods This study will enroll 20 mothers receiving first-line anti-tuberculosis medicines, together with their breastfed infants, with the aim of characterizing the breastmilk transfer of the medicines from the mother to the infants. Samples of maternal blood, breastmilk and breastfeeding infant’s blood will be obtained at specific time points for bioanalysis of drug concentrations. Pharmacokinetic data will be analyzed using a population pharmacokinetic approach. Additionally, the study will assess the psychological status of breastfeeding women and the well-being of their infants. Maternal depression is linked to long-term negative consequences for the infant’s physiological regulation, poor growth-promoting setting for the infants, and inappropriate interactive conduct, characterized by low compassion, constrained range of emotional expression, and varying provision of the infant’s budding engagement. Conclusions This study will provide the first systematic characterization of mother-to-infant transfer of first-line anti-tuberculosis medicines through breast milk. A mathematical pharmacokinetics model characterizing plasma-to-breastmilk transfer of rifampicin, isoniazid, ethambutol, and pyrazinamide will be developed and used to characterize infant exposure through breast milk. Our findings will contribute towards treatment optimization in breastfeeding and provide a framework to foster other lactation pharmacokinetic studies.
Learning for Spatial Branching: An Algorithm Selection Approach
Authors: Ghaddar Bissan , Gómez-Casares Ignacio , González-Díaz Julio , González-Rodríguez Brais , Pateiro-López Beatriz , Rodríguez-Ballesteros Sofía 
Published: May 2023

The use of machine learning techniques to improve the performance of branch-and-bound optimization algorithms is a very active area in the context of mixed integer linear problems, but little has been done for nonlinear optimization. To bridge this gap, we develop a learning framework for spatial branching and show its efficacy in the context of the Reformulation-Linearization Technique for polynomial optimization problems. The proposed learning is performed offline, based on instance-specific features and with no computational overhead when solving new instances. Novel graph-based features are introduced, which turn out to play an important role for the learning. Experiments on different benchmark instances from the literature show that the learning-based branching rule significantly outperforms the standard rules. History: Accepted by Andrea Lodi, Area Editor/Design & Analysis of Algorithms – Discrete. Funding: This work was supported by Ivey Business School (David G. Burgoyne Faculty Fellowship); FEDER [MTM2014-60191-JIN]; Spanish Ministry of Education [FPU Grant 17/02643, FPU Grant 20/01555]; Conselleria de Cultura, Educacion e Universidade [ED431C 2021/24]; Natural Sciences and Engineering Research Council of Canada [Discovery Grant 2017-04185]; Spanish Ministry of Science and Technology [MTM2017-87197-C3] and Spanish Ministry of Science and Innovation [PID2021-124030NB-C32].
Impact of ocean noise on mammalian life (case study: Samarinda waters)
Authors: Deswati Sri Ratih , Syahrir Muhammad , Mujiyanto Mujiyanto 
Published: May 2023

Noise pollution, or unwanted sounds in the ocean, can have a negative impact on marine mammals, especially on their biological behaviour when hunting for prey and changes in diving habits when leaving their habitat. This noise study was carried out in the waters of Samarinda with the help of a passive system acoustic instrument, which captures the range of sound intensity in the water column and supporting data in the form of sound range and activity above sea level. The sound range of 38.10-78.60 dB (A) above the water surface is safe for both everyday activities and as a habitat for mammals. Similarly, the underwater sound intensity between 0.84 and 138.47 dB re 1 Pa falls within this range. The noise condition in the study area is still expected. It can be used as an initial reference for the tolerance of sound intensity that applies to living things around the research location. The noise of the sea in Samarinda's waters has no effect on the lives of animals.Keywords:NoiseSound intensityMarine mammalHydrophoneSmartNoise
DORA-compliant measures of research quality and impact to assess the performance of researchers in biomedical institutions: Review of published research, international best practice and Delphi survey
Authors: Gagliardi Anna R. , Chen Rob H. C. , Boury Himani , Albert Mathieu , Chow James , DaCosta Ralph S. , Hoffman Michael , Keshavarz Behrang , Kontos Pia , Liu Jenny , McAndrews Mary Pat , Protze Stephanie 
Published: May 2023

Objective
The San Francisco Declaration on Research Assessment (DORA) advocates for assessing biomedical research quality and impact, yet academic organizations continue to employ traditional measures such as Journal Impact Factor. We aimed to identify and prioritize measures for assessing research quality and impact.

Methods
We conducted a review of published and grey literature to identify measures of research quality and impact, which we included in an online survey. We assembled a panel of researchers and research leaders, and conducted a two-round Delphi survey to prioritize measures rated as high (rated 6 or 7 by ≥ 80% of respondents) or moderate (rated 6 or 7 by ≥ 50% of respondents) importance.

Results
We identified 50 measures organized in 8 domains: relevance of the research program, challenges to research program, or productivity, team/open science, funding, innovations, publications, other dissemination, and impact. Rating of measures by 44 panelists (60%) in Round One and 24 (55%) in Round Two of a Delphi survey resulted in consensus on the high importance of 5 measures: research advances existing knowledge, research plan is innovative, an independent body of research (or fundamental role) supported by peer-reviewed research funding, research outputs relevant to discipline, and quality of the content of publications. Five measures achieved consensus on moderate importance: challenges to research productivity, potential to improve health or healthcare, team science, collaboration, and recognition by professional societies or academic bodies. There was high congruence between researchers and research leaders across disciplines.

Conclusions
Our work contributes to the field by identifying 10 DORA-compliant measures of research quality and impact, a more comprehensive and explicit set of measures than prior efforts. Research is needed to identify strategies to overcome barriers of use of DORA-compliant measures, and to “de-implement” traditional measures that do not uphold DORA principles yet are still in use.
RARE (ORPHAN) DISEASES: SOCIO–LEGAL ASPECT
Authors: Zubkova Vera S. , Ignatovskaya Irina I. , Mogrobyan Marine G. 
Published: May 2023

The article is devoted to the problem of ensuring the right to health protection and medical care, the organization and provision of medical care to children with rare (orphan) diseases are of great relevance today, due to increased attention to it not only in Russia, but throughout the world. This is mainly due to the high level of economic and social burden of rare diseases. Orphan diseases include congenital (hereditary) or acquired diseases, the frequency of which in the country and the world does not exceed a certain number established by the laws of various countries.
The low incidence of rare (orphan) diseases leads to difficulties in obtaining useful, reliable and timely information about the pathology; the correctness of the diagnosis; lack of adequate dispensary observation; limiting budgetary allocations for the development of orphan drugs and, as a result, the timely receipt of timely and appropriate treatment by people suffering from rare (orphan) diseases.
Minahasa: Islamisasi dan Warisan Peradaban Islam di Sulawesi
Authors: Azis Muhammad Nur Ichsan 
Published: May 2023

Abstract: In studies on Islamization, the Minahasa region is often overlooked because it is considered one of the regions that successfully underwent Christianization. However, upon closer examination, Islam in the Minahasa region is believed to have had contact with carriers of Islamic teachings from various regions in the Nusantara archipelago. Traces of Islamization can be found through the ongoing relationships and interactions between the community. This article uses a historical method with a descriptive-analytical social science approach. Minahasa is one of the regions with a unique legacy of Islamic civilization compared to other regions in the Nusantara. The meeting of Islam and Christianity has become a separate forum for the Minahasa community in fostering a sense of tolerance, plurality, and multiethnicity to the present day.Abstrak: Kawasan Minahasa, dalam kajian Islamisasi, seringkali dilewatkan karena dianggap sebagai salah satu kawasan yang mengalami kesuksesan dalam kristenisasi. Padahal apabila kita melihat lebih jeli, justru Islam di kawasan Minahasa dianggap lebih dahulu mengalami kontak dengan para pembawa ajaran Islam dari berbagai daerah di Nusantara. Jejak Islamisasi dapat ditemukan melalui hubungan dan interaksi masyarakat yang terus berkembang. Artikel ini merupakan tulisan yang menggunakan metode sejarah dengan pendekatan ilmu sosial yang bersifat deskriptif-analisis. Minahasa menjadi salah satu kawasan dengan warisan peradaban Islam yang cukup unik dibandingkan dengan kawasan lainnya di Nusantara. Pertemuan Islam dan Kristen menjadi wadah tersendiri bagi masyarakat Minahasa dalam menumbuhkan rasa toleransi, pluralitas, dan multietnis hingga masa sekarang ini.
Effect of sand-influence on the morphology of Mazzaella laminarioides (Rhodophyta, Gigartinales) on rocky intertidal shores
Authors: Polanco Yugreisy , Otaíza Ricardo D. , Tellier Florence , Pérez-Araneda Karla 
Published: May 2023

Abstract
Morphological variability is common among macroalgae. In central Chile, Mazzaella laminarioides extends throughout the intertidal rocky zones, where blades are reported to grow up to 20 cm in length. Nevertheless, in low rocky intertidal zones with sand-influence, blades are noticeably larger than in other shores without sand effect. The aim of this study was to compare the morphology of M. laminarioides blades from two different conditions. Blades collected from four sites with, and four without, sand-influence were evaluated with traditional morphometry. Results showed that blades were longer and wider in sand-influenced sites. Sand abrasion was not directly evaluated, but indirect effects such as the abundance of bare rock and of sand tolerant species were higher in areas with sand-influence. Also, long blades were restricted to sand-influenced sites, supporting the relation between these two variables. Molecular analyses using the COI marker confirmed large-bladed individuals as M. laminarioides. Results indicated that life cycle phase, seasonality and vertical height were not related to large blades. We suggest that restriction of large blades to sand-influenced sites may be related to the healing processes of basal holdfasts after suffering sand abrasion.
m-Isometric tensor products
Authors: Duggal Bhagawati Prashad , Kim In Hyoun 
Published: May 2023

Abstract
Given Banach space operators

S

i

{S}_{i}

and

T

i

{T}_{i}

,

i
=
1
,
2

i=1,2

, we use elementary properties of the left and right multiplication operators to prove, that if the tensor products pair

(

S

1

⊗

S

2

,

T

1

⊗

T

2

)

\left({S}_{1}\otimes {S}_{2},{T}_{1}\otimes {T}_{2})

is strictly

m

m

-isometric, i.e.,

Δ

S

1

⊗

S

2

,

T

1

⊗

T

2

m

(

I
⊗
I

)

=

∑

j
=
0

m

(

−
1

)

j

m

j

(

S

1

⊗

S

2

)

m
−
j

(

T

1

⊗

T

2

)

m
−
j

=
0

{\Delta }_{{S}_{1}\otimes {S}_{2},{T}_{1}\otimes {T}_{2}}^{m}\left(I\otimes I)={\sum }_{j=0}^{m}{\left(-1)}^{j}\left(\begin{array}{c}m\\ j\end{array}\right){\left({S}_{1}\otimes {S}_{2})}^{m-j}{\left({T}_{1}\otimes {T}_{2})}^{m-j}=0

, then there exist a non-zero scalar

c

c

and positive integers

m

1

,

m

2

≤
m

{m}_{1},{m}_{2}\le m

such that

m
=

m

1

+

m

2

−
1

m={m}_{1}+{m}_{2}-1

,

(

S

1

,
c

T

1

)

\left({S}_{1},c{T}_{1})

is strict-

m

1

{m}_{1}

-isometric and

S

2

,

1

c

T

2

\left({S}_{2},\frac{1}{c}{T}_{2}\right)

is strict

m

2

{m}_{2}

-isometric.
Una interpretación ontológica de Pedro Páramo de Juan Rulfo guiada por Rilke y Heidegger: La descripción poética del “ser” como una serie de paradojas
Authors: Weber Herwig 
Published: May 2023

Resumen
El presente trabajo es una interpretación ontológica de Pedro Páramo de Juan Rulfo a partir de conceptos interconectados de la poesía de Rainer Maria Rilke y de la filosofía de Martin Heidegger. Una de las influencias más importantes de la novela mexicana fueron algunos textos de Rilke, sobre todo las Elegías de Duino. Asimismo, entre las lecturas predilectas de Heidegger se encuentra la poesía del praguense. Se interpretará Pedro Páramo, sobre todo, mediante tres concepciones desarrolladas por los dos intelectuales europeos: el espacio universal interno (Weltinnenraum), la muerte (existencia) propia (eigentliche Existenz) y la relación entre ser y tiempo. Se demostrará que la novela de Rulfo es un acercamiento literario a la verdad del ser de los entes en un sentido rilkeano y heideggeriano.
Suicidal ideation, plan and attempt among adolescents in Houston Texas: a trend and cross-sectional analysis of the youth risk behavior survey 2011–2019 in the United States
Authors: Tundealao Samuel , Titiloye Tolulope , Sajja Anusha , Egab Iman 
Published: May 2023

Abstract

Objectives
We evaluated the trends in the prevalence of suicidal ideation, plan, and attempts among adolescents in Houston, Texas, USA, from 2011 to 2019. Furthermore, we assessed the risk factors associated with suicidal ideation, plan, and attempt among adolescents in Houston in 2019.

Methods
A cross-sectional analysis of Houston district’s Youth Risk Behavior Survey (YRBS) from 2011 to 2019. It included 11,178 adolescents aged 11–15 years in Houston middle schools. The overall and stratified (by gender, race, and ethnicity) prevalence rates were evaluated between 2011 and 2019. Factors associated with suicidal ideation, plan, and attempts in 2019 were assessed using multiple logistic regression.

Results
Suicidal ideation among adolescents increased by 2.74 % from 23.14 % in 2011–25.88 % in 2019. In 2019, we observed a 4.40 % increase in the prevalence of suicidal ideation from 2017 (21.48 %). The prevalence of suicidal plan increased by 3.76 % in 2019 (17.69 %) from 2011 (13.93 %) and by 3.99 % from 2017 (13.70 %). Suicide attempts among adolescents in Houston fluctuated from 2011 to 2019. However, there was a 1.19 % increase in prevalence in 2019 (11.62 %) compared to 2017 (10.43 %). Suicidal ideation, plan, and attempt were significantly associated with being female, Black, or African American, having ever carried a weapon, being bullied on school property, being bullied online, having ever had a cigarette, having ever had alcohol, having taken cocaine, and having used prescription pain medicine illegally/inappropriately.

Conclusions
This study found increasing rates of suicide ideation, plan, and attempts among Houston adolescents in middle schools between 2011 and 2019.
Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis
Authors: Kashani Zahra Atarodi , Pakzad Reza , Fakari Farzaneh Rashidi , Haghparast Mohammad Sadegh , Abdi Fatemeh , Kiani Zohreh , Talebi Afsaneh , Haghgoo Somaieh Moradi 
Published: May 2023

Abstract
Today, in the modern world, people are often exposed to electromagnetic waves, which can have undesirable effects on cell components that lead to differentiation and abnormalities in cell proliferation, deoxyribonucleic acid (DNA) damage, chromosomal abnormalities, cancers, and birth defects. This study aimed to investigate the effect of electromagnetic waves on fetal and childhood abnormalities. PubMed, Scopus, Web of Science, ProQuest, Cochrane Library, and Google Scholar were searched on 1 January 2023. The Cochran’s Q-test and I
2 statistics were applied to assess heterogeneity, a random-effects model was used to estimate the pooled odds ratio (OR), standardized mean difference (SMD), and mean difference for different outcomes, and a meta-regression method was utilized to investigate the factors affecting heterogeneity between studies. A total of 14 studies were included in the analysis, and the outcomes investigated were: change in gene expression, oxidant parameters, antioxidant parameters, and DNA damage parameters in the umbilical cord blood of the fetus and fetal developmental disorders, cancers, and childhood development disorders. Totally, the events of fetal and childhood abnormalities were more common in parents who have been exposed to EMFs compared to those who have not (SMD and 95% confidence interval [CI], 0.25 [0.15–0.35]; I
2, 91%). Moreover, fetal developmental disorders (OR, 1.34; CI, 1.17–1.52; I
2, 0%); cancer (OR, 1.14; CI, 1.05–1.23; I
2, 60.1%); childhood development disorders (OR, 2.10; CI, 1.00–3.21; I
2, 0%); changes in gene expression (mean difference [MD], 1.02; CI, 0.67–1.37; I
2, 93%); oxidant parameters (MD, 0.94; CI, 0.70–1.18; I
2, 61.3%); and DNA damage parameters (MD, 1.01; CI, 0.17–1.86; I
2, 91.6%) in parents who have been exposed to EMFs were more than those in parents who have not. According to meta-regression, publication year has a significant effect on heterogeneity (coefficient: 0.033; 0.009–0.057). Maternal exposure to electromagnetic fields, especially in the first trimester of pregnancy, due to the high level of stem cells and their high sensitivity to this radiation, the biochemical parameters of the umbilical cord blood examined was shown increased oxidative stress reactions, changes in protein gene expression, DNA damage, and increased embryonic abnormalities. In addition, parental exposure to ionizing and non-ionizing radiation can lead to the enhancement of different cell-based cancers and developmental disorders such as speech problems in childhood.
Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
Authors: Li Yanping , Kumar Suresh , Zhang Lihu , Wu Hongjie , Wu Hongyan 
Published: May 2023

Abstract

Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen that can cause a range of infections in hospitalized patients. With the growing use of antibiotics, MDR K. pneumoniae is more prevalent, posing additional difficulties and obstacles in clinical therapy. To provide a valuable reference to deeply understand K. pneumoniae, and also to provide the theoretical basis for clinical prevention of such bacteria infections, the antibiotic resistance and mechanism of K. pneumoniae are discussed in this article. We conducted a literature review on antibiotic resistance of K. pneumoniae. We ran a thorough literature search of PubMed, Web of Science, and Scopus, among other databases. We also thoroughly searched the literature listed in the papers. We searched all antibiotic resistance mechanisms and genes of seven important antibiotics used to treat K. pneumoniae infections. Antibiotics such as β-lactams, aminoglycosides, and quinolones are used in the treatment of K. pneumoniae infection. With both chromosomal and plasmid-encoded ARGs, this pathogen has diverse resistance genes. Carbapenem resistance genes, enlarged-spectrum β-lactamase genes, and AmpC genes are the most often β-lactamase resistance genes. K. pneumoniae is a major contributor to antibiotic resistance worldwide. Understanding K. pneumoniae antibiotic resistance mechanisms and molecular characteristics will be important for the design of targeted prevention and novel control strategies against this pathogen.
Finite element method analysis of a linear friction welded Ti6Al4V alloy
Authors: Ünal Engin , Yalçın Harun 
Published: May 2023

Abstract
Linear friction welding (LFW), which is generally used in blisk construction in aviation and space industries, is especially used to reduce costs, extend the life of materials working in hot environments, lighten engine weight, etc. The method, which is a solid state welding, achieves a high welding structure in metal and alloy materials. It can also be applied to different material combinations such as titanium alloys, superalloys, steel, aluminum, nickel, and copper. This study, which was carried out in order to provide lower cost and less raw material consumption in the welding of titanium alloys, reveals the necessity of the LFW method. In this study, the temperature change, oscillation amplitude, and oscillation frequency of the Ti6Al4V couple were investigated using the LFW method using finite elements. In the transient thermal analysis, it was observed that the temperature produced by applying Ti6Al4V welding parameters exceeded the glass transition temperature of the material.
Feed preference, body condition scoring, and growth performance of Dohne Merino ram fed varying levels of fossil shell flour
Authors: Ikusika Olusegun O. , Mpendulo Conference T. 
Published: May 2023

Abstract
Acceptability of a diet is one factor that determines an animal’s growth performance. Some feed additives in the category of dietary clay, including fossil shell flour (FSF), have been identified to enhance performance of livestock. Therefore, the influence of varying inclusion levels of FSF supplementation on feed acceptability, body condition scores, and growth performance of Dohne Merino sheep was evaluated. Twenty-four Dohne Merino rams were completely randomised and individually housed in pens for 90 days. Four different supplementation levels of FSF (0, 20, 40, and 60g/kg) were considered treatments for the rams. The average daily feed intake, body condition score, average daily weight gain (g), and coefficient of preference were significantly higher in rams supplemented with 60 g FSF/kg than the other treatments (P < 0.05). The experimental diet colour was brown for 0 g FSF/kg, while in 20, 40, and 60 g FSF/kg, it ranged from light brown to slightly deep brown. The texture of diets with 0 g FSF/kg was moderately firm, while diets with 20, 40, and 60 g FSF/kg had a firm texture. The order of preference of diets supplemented with FSF in feed intake by Dohne Merino rams was: 60 g FSF/kg > 40 g FSF/kg > 20 g FSF/kg > 0 g FSF/kg. Therefore, FSF at a minimum inclusion level of 40 g FSF/kg can improve feed intake, body condition score, and feeding behaviour of Dohne Merino rams by increasing the acceptability of the diet.