bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep vein thrombosis revealing a "silent" coeliac disease
Authors: Miranda Sofia , Clara Patrícia , Rua Joana , Cimbron Miriam , Salvador Fernando 
Published: August 2023

Introduction: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at the D2 level compatible with coeliac sprue and HLA typing positive for both DQ-2 and DQ-8. Methods: A gluten free diet was started and apixaban was suspended. Results: No new complications were reported. Discussion: Multiple mechanisms are believed to be behind the association between DVT and coeliac disease. However, to this date, no consensus exists regarding the ideal duration of anticoagulation.
Hip fracture surgery performed by cadaveric simulation-trained versus standard-trained orthopaedic trainees: a preliminary multicentre randomized controlled trial
Authors: James Hannah K. , Pattison Giles T. R. , Griffin James , Fisher Joanne D. , Griffin Damian R. 
Published: August 2023

AimsTo evaluate if, for orthopaedic trainees, additional cadaveric simulation training or standard training alone yields superior radiological and clinical outcomes in patients undergoing dynamic hip screw (DHS) fixation or hemiarthroplasty for hip fracture.MethodsThis was a preliminary, pragmatic, multicentre, parallel group randomized controlled trial in nine secondary and tertiary NHS hospitals in England. Researchers were blinded to group allocation. Overall, 40 trainees in the West Midlands were eligible: 33 agreed to take part and were randomized, five withdrew after randomization, 13 were allocated cadaveric training, and 15 were allocated standard training. The intervention was an additional two-day cadaveric simulation course. The control group received standard on-the-job training. Primary outcome was implant position on the postoperative radiograph: tip-apex distance (mm) (DHS) and leg length discrepancy (mm) (hemiarthroplasty). Secondary clinical outcomes were procedure time, length of hospital stay, acute postoperative complication rate, and 12-month mortality. Procedure-specific secondary outcomes were intraoperative radiation dose (for DHS) and postoperative blood transfusion requirement (hemiarthroplasty).ResultsEight female (29%) and 20 male trainees (71%), mean age 29.4 years, performed 317 DHS operations and 243 hemiarthroplasties during ten months of follow-up. Primary analysis was a random effect model with surgeon-level fixed effects of patient condition, patient age, and surgeon experience, with a random intercept for surgeon. Under the intention-to-treat principle, for hemiarthroplasty there was better implant position in favour of cadaveric training, measured by leg length discrepancy ≤ 10 mm (odds ratio (OR) 4.08 (95% confidence interval (CI) 1.17 to 14.22); p = 0.027). There were significantly fewer postoperative blood transfusions required in patients undergoing hemiarthroplasty by cadaveric-trained compared to standard-trained surgeons (OR 6.00 (95% CI 1.83 to 19.69); p = 0.003). For DHS, there was no significant between-group difference in implant position as measured by tip-apex distance ≤ 25 mm (OR 6.47 (95% CI 0.97 to 43.05); p = 0.053). No between-group differences were observed for any secondary clinical outcomes.ConclusionTrainees randomized to additional cadaveric training performed hip fracture fixation with better implant positioning and fewer postoperative blood transfusions in hemiarthroplasty. This effect, which was previously unknown, may be a consequence of the intervention. Further study is required.Cite this article: Bone Jt Open 2023;4(8):602–611.
Inverse scattering with a parametrized spatial spectral volume integral equation for finite scatterers
Authors: Eijsvogel S. , Dilz R. J. , van Beurden M. C. 
Published: August 2023

In wafer metrology, the knowledge of the photomask together with the deposition process only reveals the approximate geometry and material properties of the structures on a wafer as a priori information. With this prior information and a parametrized description of the scatterers, we demonstrate the performance of the Gauss–Newton method for the precise and noise-robust reconstruction of the actual structures, without further regularization of the inverse problem. The structures are modeled as 3D finite dielectric scatterers with a uniform polygonal cross-section along their height, embedded in a planarly layered medium. A continuous parametrization in terms of the homogeneous permittivity and the vertex coordinates of the polygons is employed. By combining the global Gabor frame in the spatial spectral Maxwell solver with the consistent parametrization of the structures, the underlying linear system of the Maxwell solver inherits all the continuity properties of the parametrization. Two synthetically generated test cases demonstrate the noise-robust reconstruction of the parameters by surpassing the reconstruction capabilities of traditional imaging methods at signal-to-noise ratios up to −3dB with geometrical errors below λ/7, where λ is the illumination wavelength. For signal-to-noise ratios of 10 dB, the geometrical parameters are reconstructed with errors of approximately λ/60, and the material properties are reconstructed with errors of around 0.03%. The continuity properties of the Maxwell solver and the use of prior information are key contributors to these results.
Autoimmunity and autoinflammation — the key to understanding the pathogenesis of osteoarthritis and developing new ways for its prevention and therapy
Authors: Sarvilina I. V. , Lila A. M. , Alekseeva L. I. , Gromova O. A. , Taskina E. A. 
Published: August 2023

The review considers the full spectrum of currently known autoantigens in osteoarthritis (OA) and discusses their role in the development and/or persistence of synovitis and the initiation of subsequent destruction of articular cartilage with the development of an autoimmune response and auto-inflammation. Of great interest are methods of drug prevention of OA considering autoimmunity responses and associated auto-inflammation, including the use of pharmaconutraceuticals.Preclinical and clinical studies of the safety and efficacy of pharmaconutraceuticals containing native type II collagen are presented. A clear relationship between the composition/chemical structure of the collagen components and its mechanism of action and efficacy is discussed. Taking into account the autoimmune pathogenesis of OA, new combined pharmaconutraceuticals aimed at reducing the manifestations of autoinflammation (chondroitin sulfate, glucosamine sulfate) are developed. They have an optimal ratio of active ingredients with a sufficient level of evidence, which allows enhancing their beneficial pharmacological effects.
DNA double-strand breaks in immunoinflammatory rheumatic diseases
Authors: Avdeeva A. S. , Aleksankin A. P. , Verizhnikova Zh. G. , Rybakova V. V. , Diatroptov M. E. , Gorbunova Yu. N. , Mesnyankina A. A. , Paranich D. A. , Lila A. M. , Nasonov E. L. 
Published: August 2023

Objective: To study the frequency of spontaneous foci of DNA double-strand breaks (DSBs) in patients with immune-inflammatory rheumatic diseases (IIRD), their relationship to disease activity, levels of inflammatory markers, and levels of autoantibodies.Material and methods. The analysis included 40 patients with IIRD, including 19 patients with rheumatoid arthritis (RA, including 16 women, median disease duration 60 [20; 103] months, DAS28 was 5.05 [4.06; 5.9]) and 21 patients with systemic lupus erythematosus (SLE, 19 women, median disease duration 96.0 [40.0; 158.0] months, SLEDAI-2K 8.0 [4.0; 12.0]). The control group consisted of 17 healthy donors matched for sex and age.DNA DSBs were identified as discrete foci by immunofluorescence staining of lymphocyte cultures with antibodies against γH2AX and 53BP1 and subsequently analysed using the automated AKLIDES automated platform (Medipan).Results and discussion. There were no significant differences in the number of spontaneous DNA DSBs in patients with RA and healthy donors (p>0.05), a lower number of cells with the 53BP1 focus and a lower percentage of cells damaged in this focus were found in patients with SLE than in controls. There was a positive correlation between the number of γH2AXdamaged cells and CDAI(r=0.45, p=0.035), the number of cells with 53BP1 ruptures and the level of rheumatoid factor IgM (r=0.63, p=0.005) and ESR (r=0.53, p=0.02). In the group of SLE patients, a positive correlation was observed between the number of cells with breaks in the γH2AX focus and the level of antibodies against double-stranded DNA (anti-dsDNA; r=0.56, p=0.007), the average number of breaks in the cell in the γH2AX focus with the level of anti-dsDNA (r=0.57, p=0.004).Conclusion. The number of DNA DSBs may be an additional indicator of IIRD activity. In patients with SLE, DNA repair processes appear to be impaired, which is associated with the high activity of the disease.
Citrullinated histone H3 in systemic lupus erythematosus and antiphospholipid syndrome (preliminary results)
Authors: Nurbaeva K. S. , Reshetnyak T. M. , Cherkasova M. V. , Lila A. M. 
Published: August 2023

Citrullinated histone H3 (CitH3) is a specific marker for NETosis; its role in determining the clinical and laboratory manifestations of systemic lupus erythematosus (SLE) remains to be elucidated.Objective: To evaluate the role of CitH3 in the development of clinical and laboratory manifestations in patients with SLE with and without an-tiphospholipid syndrome (APS).Material and methods. The study included 30 patients with SLE and 39 with SLE+APS, including 51 (73.9%) women and 18 (26.1%) men. The median age of the patients was 36 [32; 46.5] years. The control group consisted of 26 healthy individuals.SLE activity was assessed by the SLEDAI-2K index. Patients were divided into two groups: 41 patients with moderate and high SLE activity (SLEDAI-2K ≥6) were included in the first group, and 28 patients with low activity or remission (SLEDAI-2K <6) were included in the second group.CitH3 content in blood serum was determined by enzyme immunoassay using a set of reagents for the assay of CitH3 (BlueGene Biotech, China) according to the manufacturer's instructions.Results and discussion. CitH3 content in blood serum was significantly higher in SLE than in the control group (p=0.048). High blood serum CitH3 content was associated with moderate and high SLE activity (p=0.039). CitH3 concentration was inversely correlated with lymphocyte count but was not related to immunological parameters. Increased CitH3 levels were associated with photosensitivity, while lower levels were associated with a history of serositis. There were no significant differences between blood serum CitH3 levels in patients with SLE and SLE+APS (p=0.39).Conclusion. The concentration of a specific marker for NETosis, CitH3, is increased in patients with SLE, and this increase is associated with moderate and high disease activity.
Clinical and immunologic features of the phenotype of systemic lupus erythematosus combined with Sjögren's syndrome
Authors: Solovyev S. K. , Aseeva E. A. , Baranov A. A. , Lila A. M. , Nikishina N. Yu. , Glukhova S. I. 
Published: August 2023

The problem of clinical and immunological heterogeneity of systemic lupus erythematosus (SLE) is of great interest, especially the combination of SLE and Sjögren's syndrome (SjS) determines a more favorable prognosis and specifics of therapy.Objective: to characterize the clinical and immunological features of SLE combined with SjS.Material and methods. The retrospective study included 44 patients with SLE combined with SjS and 356 patients with SLE without SjS, hospitalized at the V.A. Nasonova Research Institute of Rheumatology between 2013 and 2021. The two groups of patients were compared in terms of life expectancy, clinical manifestations, laboratory parameters and therapy.Results and discussion. The following phenotypic features of the clinical and immunological variant of SLE combined with SjS were found: significantly longer duration of SLE (p<0.01); higher incidence of polyarthritis (p=0.01) and Raynaud's syndrome (p<0.003) at disease onset. Subacute cutaneous lupus erythematosus, Raynaud's syndrome, peripheral nervous system involvement (sensory polyneuropathy and distal sensory-motor polyneuropathy) were found more frequently in SLE combined with SjS than in SLE without SjS, p<0.0001. Among laboratory abnormalities in SLE patients with SjS, leukopenia (p<0.0001), antibodies to SSA/Ro, SSB/La, and rheumatoid factor (p<0.0001) were observed in a greater number of cases. In the group of SLE combined with SjS, the chronic variant of SLE course according to the classification of V.A. Nasonova, and lower activity were observed, which didn't not require therapy with high doses of glucocorticoids; in this group, rituximab (p<0.01), cyclophosphamide and methotrexate were used significantly more often.Conclusion. Thus, significant clinical and laboratory differences were found between SLE with SjS and without SjS. They determine prognosis, approaches to pathogenetic therapy and monitoring.
Comorbid infections in patients with spondyloarthritis: frequency, structure and risk factors
Authors: Baranova M. M. , Muravyeva N. V. , Belov B. S. , Korotaeva T. V. , Glukhova S. I. 
Published: August 2023

Objective: To investigate the frequency, structure, and risk factors of comorbid infections (CI) in patients with spondyloarthritis (SpA).Material and methods. The study included 332 patients with SpA. Patients were interviewed by the investigating physician, and additional information was obtained from medical records.Results and discussion. Respiratory tract (RT) and ear, nose, and throat (ENT) infections ranked first in the structure of CI. Exacerbation of SpA after CI was found in 42% of patients, and more severe CI against the background of SpA was found in 83 patients. 63 cases of severe CI (SCI) were documented, 63.5% of which were infections of the RT and ENT organs. Predictors for the development of lower RT (LRT) and ENT organ infections were the use of biologic disease-modifying antirheumatic drugs (bDMARDs) in general (odds ratio, OR 2.018; 95% confidence interval, CI 1.221-3.335; p=0.006 and OR 1.761; 95% CI 1.1-2.819, respectively; p=0.018) and tumor necrosis factor-α (TNF-α) inhibitors in particular (OR 2.376; 95% CI 1.417-3.983; p=0.001 and OR 1.833; 95% CI 1.123-2.994; p=0.015), and disease duration of more than 5 years (OR 1.774; 95% CI 1.034—3.042; p=0.037 and OR 2.22; 95% CI 1.378-3.576; p=0.001). The risk of developing LRT infection was higher in the presence of chronic lung disease (OR 3.673; 95% CI 1.602-8.425; p=0.002) and Charlesson Comorbidity Index ≥1 (OR 2.381; 95% CI 1.439-3.94; p=0.001), risk of developing ENT organ infections - with the use of >1 bDMARD (OR 2.4; 95% CI 1.199-4.804; p=0.013) and duration of methotrexate therapy over 5 years (OR 2.478; 95% CI 1.053-5.831; p=0.038). Risk factors for the development of SCI were the use of bDMARDs in general (OR 1.941; 95% CI 1.063-3.545; p=0.031) and TNFα in particular (OR 2.246; 95%, CI 1.218-4.139; p=0.01).Conclusion. The problem of CI in SpA is of great importance. The vast majority of patients with SpA should be vaccinated against pneumococcal infection and influenza.
Early diagnosis of coxitis in ankylosing spondylitis
Authors: Erdes Sh. F. , Agafonova E. M. , Dubinina T. V. , Demina A. B. , Smirnov A. V. 
Published: August 2023

Coxitis is one of the characteristic clinical manifestations of ankylosing spondylitis (AS). Hip joint (HJ) involvement in AS is considered an un-favorable prognostic factor. Early detection of coxitis is of great importance, since with the timely initiation of adequate treatment, the risk of developing irreversible changes in HJ can be reduced.The lecture discusses the issues of clinical and instrumental diagnosis of coxitis in AS and presents an algorithm for its early detection developed by the authors.
Genesa Marmer Daerah Mata Wawatu dan Sanggula, Kecamatan Moramo Utara, Konawe Selatan Berdasarkan Karakteristik Tekstur, Struktur, dan Asosiasi Batuannya
Authors: Azzaman Muhammad Arba , Titisari Anastasia Dewi 
Published: August 2023

Salah satu daerah penghasil marmer di Provinsi Sulawesi Tenggara adalah Desa Mata Wawatu dan Sanggula, Kecamatan Moramo Utara, Kabupaten Konawe Selatan. Penelitian ini dilakukan untuk menginterpretasi genesa marmer yang meliputi tipe dan fasies metarmorfisme berdasarkan karakteristik tekstur, struktur, dan asosiasi batuannya. Ketiga parameter tersebut diketahui dengan melakukan observasi geologi, deskripsi singkapan dan sampel batuan, dan analisis petrografi. Hasilnya menunjukkan bahwa lokasi penelitian tersusun oleh tiga satuan batuan, yaitu Satuan Marmer, Satuan Filit, dan Satuan Konglomerat dengan struktur geologi berupa kekar, sesar geser sinistral, dan sesar geser sinistral diperkirakan yang terbentuk oleh gaya utama berarah relatif utara timur laut – selatan barat daya. Filit memperlihatkan stuktur foliasi tipe filitik dan tekstur hipidioblastik, kristaloblastik, dan lepidoblastik serta tekstur khusus berupa augen dan mortar. Mineralogi filit terdiri dari kuarsa, muskovit, grafit, klorit, dan mineral opak. Sementara itu, marmer di daerah penelitian menunjukkan struktur non foliasi. Namun, di beberapa tempat marmer menunjukkan retakan–retakan intensif dan struktur syn-genetic berupa perlapisan yang diduga merupakan struktur batuan asalnya, dengan variasi tekstur berupa hipidioblastik, xenoblastik, kristaloblastik, nematoblastik, granoblastik, granuloblastik serta tekstur khusus yang terdiri tekstur augen, saccaroidal, dan mortar. Komposisi marmer tersusun oleh mineral kalsit, dolomit, kuarsa, muskovit, klorit dan mineral opak. Karakteristik tekstur dan struktur pada marmer serta asosiasi batuan termasuk himpunan mineralnya mengindikasikan bahwa marmer di lokasi penelitian terbentuk oleh proses metamorfisme regional, bersama dengan filit, pada fasies sekis hijau.
Preparation and performance of homogenous braids-reinforced poly (p-phenylene terephthamide) hollow fiber membranes
Authors: Wang Chun , Yan Dinghe , Song Shubin , Yan Jingjing , Xue Haolong , Xiao Changfa 
Published: August 2023

Abstract
A novel homogenous braid-reinforced (HBR) poly (p-phenylene terephthamide) (PPTA) hollow fiber membrane was prepared in this study. The effects of PPTA concentration on the morphologies and properties of the membranes were further investigated. The results showed that when the PPTA concentration was 2.0 wt%, the cross-sectional morphology of satisfactory interfacial bonding was achieved and the permeation was still maintained at about 200 (L·m−2·h−1) after ultrasonic vibration. In addition, the tensile force exceeded 600 N, which indicated that the homogeneous effect effectively improved the poor mechanical properties and interfacial bonding. In addition, the HBR PPTA hollow fiber membranes were applied to simulate the membrane bioreactor system to explore the control factors of membrane fouling. The results demonstrated that the average removal of total phosphorus and NH4
+–N was above 49% and 96%, respectively; meanwhile, the operating time was up to 120 days. Furthermore, it was easier to nearly remove the pollutants by chemical cleaning.
The intersection of technology and mental health: enhancing access and care
Authors: Altaf Dar Mohd , Maqbool Mudasir , Ara Irfat , Zehravi Mehrukh 
Published: August 2023

Abstract
In recent times, technology has increasingly become a central force in shaping the landscape of mental health care. The integration of various technological advancements, such as teletherapy, virtual care platforms, mental health apps, and wearable devices, holds great promise in improving access to mental health services and enhancing overall care. Technology’s impact on mental health care is multi-faceted. Teletherapy and virtual care have brought about a revolution in service delivery, eliminating geographical barriers and offering individuals convenient and flexible access to therapy. Mobile mental health apps empower users to monitor their emotional well-being, practice mindfulness, and access self-help resources on the move. Furthermore, wearable devices equipped with biometric data can provide valuable insights into stress levels and sleep patterns, potentially serving as valuable indicators of mental health status. However, integrating technology into mental health care comes with several challenges and ethical considerations. Bridging the digital divide is a concern, as not everyone has equal access to technology or the necessary digital literacy. Ensuring privacy and data security is crucial to safeguard sensitive client information. The rapid proliferation of mental health apps calls for careful assessment and regulation to promote evidence-based practices and ensure the delivery of quality interventions. Looking ahead, it is vital to consider future implications and adopt relevant recommendations to fully harness technology’s potential in mental health care. Continuous research is essential to evaluate the efficacy and safety of digital interventions, fostering collaboration between researchers, mental health professionals, and technology developers. Proper training on ethical technology utilization is necessary for mental health practitioners to maintain therapeutic boundaries while leveraging technological advancements responsibly.
Prehabilitation in elective surgical interventions – what must the general and abdominal surgeon know
Authors: Meißner Carl , Meyer Frank , Ridwelski Karsten 
Published: August 2023

Abstract

Objectives
For years, many efforts have been invested to prepare patients, in particular, those with reduced physical and psychic status, much better to provide and finally achieve better outocme if there is time available to provide several beneficial measures.

Methods
Therefore, the objective was to illustrate the concept and various single elements of a complex prehabilitation concept based on (i) selective references from the medical literature and (ii) own clinical experiences from clinical practice in general and abdominal surgery.

Results
Prehabiliation can be considered the solution of the efforts to improve preoperative status for patients in a disadvantageous status for almost all types of surgery and all other operative and/or interventional procedures. It is the targeted process to improve individual functionality and organ function before a planned (elective) surgical intervention; P. comprises basically nutritional, physical and psychological measures; P. focusses especially onto the elderly, frail and malnourished patients before a planned surgical intervention; the overall aim is to significantly improve final outcome characterized by shorter length of stay, lower complication rate and mortality as well as cost efficiency; P. is especially important in cancer surgery, in which the beneficial effects can be particularly implemented; P. programs and/or “Standard Operating Protocols“ (SOP) may help to establish and materialize its single aspects and enhanced recovery after surgery (ERAS). There is still further potential to reliably establish and to utilize the options of prehabilitation measures as listed above.

Conclusions
Prehabiliation is an indispensable aspect in today’s preparation for elective surgery, which needs to become obligatory part of the preparation measures to planned surgical interventions, which can further contribute to a better final outcome and ERAS as well as, in addtion, needs to be further developed and accomplished.
Crystal structure of poly[diaqua-(bis(μ2-1,4-bis(imidazol-1-ylmethyl)benzene)-κ2
N,N′] cobalt(II)-tetraqua-bis(1,4-bis(imidazol-1-ylmethyl)benzene)-κ1N)-cobalt(II) di(2,5-thiophenedicarboxylate) dihydrate, C68H76Co2N16O16S2
Authors: Chen Jie , Liu Yang 
Published: August 2023

Abstract
C68H76Co2N16O16S2, monoclinic, P21/c (no. 14), a = 14.097(10) Å, b = 19.208(15) Å, c = 18.998(10) Å, β = 130.71(3)°, V = 3899(5) Å3, Z = 4, R
gt(F) = 0.0361, wR
ref(F
2) = 0.0850, T = 296.15 K.