bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggressive behaviour in moray eels versus species identity: Do I oust you, or do I eat you?
Authors: Lim Jia-Yi , Guan Kang-Long , Schönberg Christine Hanna Lydia 
Published: January 2023

Abstract
Observing a fight between two snowflake eels in southern Taiwan, we had difficulties locating scientific information on eel-eel aggressive behaviour and looked further afield. We collected and scored 34 videos posted on social media, to provide more insight into this behaviour. The videos showed 12 different species of moray to fight, with the genus Gymnothorax contributing ~ 71% of the films, Echidna to 24%. 82% of the retrieved videos showed same-species encounters. Fights involved “knotting”, when opponents curl around each other and shove with their bodies, and some biting. Overall, incidence of injury and death of losers, as well as injury of winners, was higher in smaller opponents. Conspecificity created the largest difference in behaviour. Available same-species encounters were interpreted as rivalry, as in our video. This normally included a visible resource the opponents fought over (a den, a food item, a mate). Same-species fights started after gaping mouths at each other, with individuals being roughly equal in size. Conspecific opponents were often injured, but never killed. Available videos with fights between different species showed predator attacks and defence in reaction. Except for one case, different-species encounters ended with one eel being killed and eaten, the winner always a fish-eating Gymnothorax species. Pre-fight, the killer was seen displaying food searching behaviour by checking holes. Both, same- and different-species fights frequently incurred deep, V-shaped wounds that were not apparently life threatening. Old V-shaped scars occurred on the bodies of some eels. Such scars could be used in research studying moray aggressive behaviour.
Cyclic distribution and ordering of occurrence of prime and composite numbers
Authors: Berezowski Marek 
Published: January 2023

Abstract
This paper presents a simple analytical method for identifying prime numbers and determining composite numbers. It has been shown that the primes are ordered and all are placed on 96 half-lines. One linear equation and 8 numbers are enough for all calculations. In addition, the astonishing cyclical nature of the occurrence of composite numbers has been demonstrated.
Rupture processes of the 2021 and 2022 Fukushima-oki earthquakes: Adjacent events on the complex fault system in the subducting slab
Authors: Kobayashi Hiroaki , Watanabe Tetsushi , Koketsu Kazuki 
Published: January 2023

Abstract
The 2021 Mw 7.1 and 2022 Mw 7.4 Fukushima-oki earthquakes ruptured adjacent regions in the subducting slab, which gave us a good opportunity to better understand the rupture process of an intraslab earthquake and the fault system in a subducting slab hosting such large earthquakes. We developed source models of the two earthquakes by constructing fault models based on the distributions of relocated aftershocks and performing joint source inversion using strong motion, teleseismic and geodetic data. The results showed that the 2021 earthquake was initiated by the west-northwest dipping fault and that it then ruptured the east-southeast dipping fault. The rupture propagated to the southwest and up-dip directions. For the 2022 earthquake, the rupture primarily propagated to the north-northeast and up-dip directions on the east-southeast dipping fault, but a delayed rupture occurred around the hypocenter approximately 12 s after the rupture initiation. This was probably due to the complex fault system around the hypocenter. Our source models accurately reproduced observed data for both earthquakes. We found that the source faults of these earthquakes had similarities to faults in the outer-rise region, which suggests that the 2021 and 2022 earthquakes occurred on faults that originally formed in the outer-rise region and reactivated in the subducting slab.
On Transformed Graphs
Authors: Sarkar Ishita , Nanjappa Manjunath , Gutman Ivan 
Published: January 2023

Abstract
The network systems and graphical analysis through the study ofstructural characteristics is a vast field of growing importance inresearch. Topological indices have a significant and crucial role inthe study of structure–property relationships. In this paper, weexamine constructional transformed networks constructed by unique vertex-edge incidence and mutual adjacency associations. Expres-sions for the first and second hyper Zagreb indices and co-indices of these transformed networks and their complements are obtained.
MSC Classification: 05C09 , 05C90 , 05C92
No major difference in perceived quality of care in patients with hip or knee osteoarthritis assessed in a physical therapy-led triage compared with standard care: a randomized controlled trial
Authors: Gustavsson Linnéa , Beischer Susanne , Samsson Karin , Ardebili Maziar Mohaddes 
Published: January 2023

Abstract
Background: Physical therapy-led orthopedic triage is a care model used to optimize pathways for patients with hip or knee osteoarthritis. However, scientific evidence of the effectiveness of this model of care is still limited and only a few studies report patients’ perception of it. The aim of this study was to compare patients’ perceived quality of care after physical therapy-led triage with standard practice in a secondary care setting for patients with primary hip or knee osteoarthritis.
Methods: In this randomized study, patients with hip or knee osteoarthritis referred for an orthopedic consultation received either physical therapy-led triage (n=344) or a standard care assessment by an orthopedic surgeon (n=294). To evaluate the patients’ perceived quality of care, a short version of the Quality from the Patient’s Perspective questionnaire was sent to the patients within a week after their assessment. The primary outcome was the statement “I received the best examination and treatment”.
Results: A total of 348 patients (70%, Physical therapy-led triage: n=249, Standard care: n=199) answered the questionnaire. No significant difference was found in the primary outcome between the groups (p=0.6). Participants in the triage group perceived themselves to have received significantly better information about how to take care of their osteoarthritis (p=0.017) compared with the standard care group. The standard care group reported that they participated in the decision-making process (p=0.005) to a greater extent, that their expectations were met (p=0.013) to a greater degree and that their care depended more on their need for care rather than the caregivers’ routines.
Conclusion: Both groups report high perceived quality of care. Significant differences were found in four of 14 questions, one in favor of the physical therapist and three in favor of the standard care group. The results in the present study suggest that physical therapy-led triage can be implemented for patients with hip or knee osteoarthritis at a secondary care unit.
Trial registration: Clinical Trials NCT04665908, registered 14/12/2020
Inactivation of TRPM7 kinase targets AKT signaling and cyclooxygenase-2 expression in human CML cells
Authors: Hoeger Birgit , Nadolni Wiebke , Hampe Sarah , Hoelting Kilian , Fraticelli Marco , Zaborsky Nadja , Madlmayr Anna , Sperrer Viktoria , Fraticelli Laura , Addington Lynda , Steinritz Dirk , Chubanov Vladimir , Geisberger Roland , Greil Richard , Breit Andreas , Boekhoff Ingrid , Gudermann Thomas , Zierler Susanna 
Published: January 2023

Abstract
Cyclooxygenase-2 (COX-2) is a key regulator of inflammation. High constitutive COX-2 expression enhances survival and proliferation of tumor cells, whereas it adversely impacts anti-tumor immunity. We recently identified the melastatin-like transient-receptor-potential-7 (TRPM7) protein as modulator of immune homeostasis. TRPM7 is essential for leukocyte proliferation and differentiation, and upregulated in several cancer tissues. It combines a cation channel with an α-kinase, which is linked to inflammatory cell responses, and associated with hallmarks of tumor progression. A role in leukemia is not established. Here, we show that inhibiting TRPM7 in CML patient cells results in reduced constitutive COX-2 expression and cell proliferation. Using the CML-derived cell line HAP1 harboring CRISPR/Cas9-mediated TRPM7 knockout or a point mutation inactivating TRPM7 kinase, we could link this defect to reduced AKT activation. Pharmacologic blockade of TRPM7 in wildtype HAP1 cells confirmed the effect on COX-2 via altered AKT signaling. Addition of an AKT activator on TRPM7 kinase-dead cells reconstituted the phenotype. Inhibition of TRPM7 resulted in reduced COX-2 expression in peripheral blood mononuclear cells derived from CML patients, and diminished patient-derived CD34+ cell proliferation. We highlight a role of TRPM7 kinase in AKT-driven COX-2 expression, and suggest a beneficial potential of TRPM7 blockade in COX-2-directed chemotherapy.
Imaging and histologic evaluation of the long head of the biceps tendon in a rotator cuff tear rat model
Authors: Kajiwara Daisuke , Ochiai Nobuyasu , Hashimoto Eiko , Hirosawa Naoya , Akimoto Koji , Nojima Daisuke , Shimada Yohei , Ise Shohei , Ohtori Seiji 
Published: January 2023

Abstract
Background: A comparison of changes in the long head of the biceps tendon for different types of rotator cuff tears has not been previously performed. Furthermore, the correlation between the thickening and degeneration of the long head of the biceps tendon and the cause of these changes have not been fully clarified. We evaluated the relationship between degenerative changes in the long head of the biceps tendon and rotator cuff tears in a rat model using imaging and histology.
Methods: Ninety-six 12-week-old Sprague-Dawley rats were divided into anterior (subscapularis tear), anterosuperior (subscapularis, supraspinatus, and infraspinatus tears), superior (supraspinatus and infraspinatus tears), and control groups. The long head of the biceps tendon was harvested at 4 or 12 weeks postoperatively. The cross-sectional areas of the intra- and extra-capsular components of the tendon were measured using micro-computed tomography, and the affected/normal ratio of the cross-sectional area was calculated. Masson’s trichrome staining and Alcian blue staining were performed for histologic analysis, with degenerative changes described using the modified Bonar scale. The correlation between the affected/normal ratio and Bonar scores was evaluated.
Results: The affected/normal ratio was higher for the anterior and anterosuperior groups than for the control group at 4 and 12 weeks. The ratio increased for the intra-articular portion in the superior group and for both the intra- and extra-articular portions in the anterior and anterosuperior groups. Degeneration considerably progressed in the anterior and anterosuperior groups compared with the control group from weeks 4 to 12 and was greater in the intra- than in the extra-articular portion. The ratio correlated with extracellular matrix score.
Conclusions: Subscapularis tears were associated with progressive thickening and degeneration of the long head of the biceps tendon at 4 and 12 weeks postoperatively, which was more significant in the intra- than in the extra-articular portion. Histologic evaluation indicated that the extracellular matrix likely caused these degenerative changes.
Does resection after neoadjuvant chemotherapy of Docetaxel, oxaliplatin, and S-1 (DOS regimen) benefit for gastric cancer patients with single non-curable factor? A multicenter, prospective cohort study (Neo-REGATTA)
Authors: Cui Yuehong , Yu Yiyi , Zheng Song , Ying Jie’er , Du Yi’an , Wang Yan , Wang Xuefei , Shen Zhenbin , Liu Fenglin , Lv Minzhi , Sun Yihong , Liu Tianshu 
Published: January 2023

Abstract
Background
The Neo-REGATTA study evaluated the effectiveness and safety of Docetaxel, oxaliplatin, and S-1 (DOS regimen) followed by radical resection vs. chemotherapy in advanced gastric adenocarcinoma patients with single non-curable factor.
Methods
This cohort study prospectively enrolled advanced gastric adenocarcinoma patients with single non-curable factor between November 2017 and June 2021. Patients without progression after four cycles of DOS were divided into resection group and chemotherapy group. The outcomes included overall survival (OS), progression-free survival (PFS) and safety. Effectiveness analysis was also performed by propensity score matching (PSM).
Results
A total of 73 patients were enrolled and 13 patients were withdrawn due to disease progression after 4 cycles of DOS. Afterwards, 35 and 25 participants were in the resection and chemotherapy groups, respectively. After a median follow-up time of 19.5 months (5–48 months), the median PFS and OS were 9.0 months, and 18.0 months for the chemotherapy group, but not reached in the resection group. After PSM, 19 matched participants were in each group. The OS was longer in resection group than that in chemotherapy group (HR = 0.19, 95% CI: 0.05–0.70, P = 0.013). The PFS was longer in resection group than that in chemotherapy group (HR = 0.22, 95% CI: 0.07–0.68, P = 0.009). The most common grade 3 or 4 adverse events in both groups were neutropenia (5.7%, 8.0%) and leukopenia (5.7%, 8.0%), respectively.
Conclusions
Radical resection might provide survival benefit compared with continuous chemotherapy alone in advanced gastric adenocarcinoma patients who had a disease control after DOS, with a good safety profile.
Trial registration:
The study protocol was registered on ClinicalTrial.gov (NCT03001726, 23/12/2016).
Multifunctional solar water harvester with high transport selectivity and fouling rejection capacity
Authors: Hao Xuanzhang , Yao Houze , Zhang Panpan , Liao Qihua , Zhu Kaixuan , Jian Chang , Cheng Huhu , Yuan Jiayin , Qu Liangti 
Published: January 2023

Abstract
Shortage of clean water continues to grow around the world, and the recent solar-powered interfacial system has emerged as a sustainable, efficient and CO2-neutral strategy to produce clean water. However, complex contaminants in surface water in accompany with environment pollution set huge obstacles for harvesting clean water via using sunlight as the energy input. Inspired by the surface structure of fish-scale, we herein develop a solar-powered graphene/alginate hydrogel (GAH)-based clean water extractor of super resistance to the transport of complex contaminants and ultra-antifouling capacity. This GAH features a high selectivity in water transport by rejecting > 99.5% of volatile organic compounds (VOCs), > 99.3% of ions (Na+, Mg2+, K+, Ca2+), 100% of non-volatile organic compounds (NOCs) and bacteria; meanwhile GAH is capable of rejecting oil adhesion by forming large contact angle >140o under water, deactivating nearly 100% bacteria on surface and preventing salt crystallization. Given such promising adaptability to a wide environment, this GAH can directly convert surface water of complex components into safe water that meets drinking standards.
Incidence of cleft lip and palate, and epidemiology of perinatal deaths related to cleft lip and palate in Hunan Province, China, 2016-2020
Authors: Zhou Xu , Fang Junqun , Wang Hua , Xie Donghua , Kuang Haiyan , Li Ting , Liu Qing , He Jian 
Published: January 2023

Abstract
Background
This study aimed to analyze the incidence of cleft lip and/or palate (CL/P) and the epidemiology of perinatal death related to CL/P.
Methods
We used data from the Birth Defects Surveillance System of Hunan Province, China, from 2016 to 2020. The surveillance data of perinatal infants (for stillbirth, dead fetus, or live birth between 28 weeks of gestation and seven days after birth) were analyzed. We computed the incidences of CL/P and 95% confidence intervals (CI) by Poisson regression. Furthermore, we analyzed the epidemiology of perinatal deaths related to CL/P.
Results
A total of 847755 perinatal infants were registered between 2016–2020. 14459 birth defects were identified, including 685 (4.74%) CL/P. The incidence of CL/P was 0.81‰ (0.75–0.87‰) (per 1000 perinatal infants). And the incidences of the cleft lip only (CL) was 0.20‰ (0.17–0.23‰) (169 cases), of cleft palate only (CP) was 0.30‰ (0.26–0.33‰) (252 cases), and of cleft lip with palate (CLP) was 0.31‰ (0.27–0.35‰) (264 cases). The incidence of CL was higher in males than females (OR = 1.62, 95%CI: 1.18–2.22). The incidence of CP was higher in urban than rural (OR = 1.43, 95%CI: 1.12–1.83) and lower in males than females (OR = 0.59, 95%CI: 0.46–0.75). The incidence of CLP was higher in urban than in rural (OR = 1.36, 95%CI: 1.06–1.74). Compared to maternal aged 25–29 years, maternal aged < 20 years was a risk factor for CLP (OR = 3.62, 95%CI: 2.07–6.33) and CL/P (OR = 1.80, 95%CI: 1.13–2.86), and maternal aged ≥ 35 years was risk factor for CLP (OR = 1.43, 95%CI: 1.01–2.02). CL/P related perinatal deaths accounted for 24.96% (171/685) of all CL/P, of which 90.64% (155/171) were aborted. Rural residents, low income, low maternal age, and early prenatal diagnosis are risk factors for perinatal death.
Conclusion
This study contributes to a better understanding of the incidence and risk factors of CL/P in Hunan Province, China, which is important for public health decision-making and further research.
Implementation of Evidence-Based Multiple Focus Integrated Intensified TB Screening to End TB (EXIT-TB) package in East Africa: A Qualitative study
Authors: Isangula Kahabi , Philbert Doreen , Ngari Florence , Ajeme Tigest , Kimaro Godfather , Yimer Getnet , Mnyambwa Nicholaus P , Muttamba Winters , Najjingo Irene , Wilfred Aman , Mshiu Johnson , Kirenga Bruce , Wandiga Steve , Mmbaga Blandina Theophil , Donard Francis , Okelloh Douglas , Mtesha Benson , Mohammed Hussen , Semvua Hadija , Ngocho James , Mfinanga Sayoki , Ngadaya Esther 
Published: January 2023

Abstract

INTRODUCTION Tuberculosis (TB) remains a major cause of morbidity and mortality, especially in sub-Saharan Africa. We qualitatively evaluated the implementation of an Evidence-Based Multiple Focus Integrated Intensified TB Screening package (EXIT-TB) in the East African region, aimed at increasing TB case detection and number of patients receiving care. OBJECTIVE We present the accounts of participants from Tanzania, Kenya, Uganda, and Ethiopia regarding the implementation of EXIT-TB, and suggestions for scaling up. METHODS A qualitative descriptive design was used to gather insights from purposefully selected healthcare workers, community health workers, and other stakeholders. A total of 27, 13, 14, and 19 in-depth interviews were conducted in Tanzania, Kenya, Uganda, and Ethiopia respectively. Data were transcribed and translated simultaneously and then thematically analysed. RESULTS The EXIT-TB project was described to contribute to increased TB case detection, improved detection of Multidrug-resistant TB patients, reduced delays and waiting time for diagnosis, raised the index of TB suspicion, and improved decision-making among HCWs. The attributes of TB case detection were: (i) free X-ray screening services; (ii) integrating TB case-finding activities in other clinics such as Reproductive and Child Health clinics (RCH), and diabetic clinics; (iii), engagement of CHWs, policymakers, and ministry level program managers; (iv) enhanced community awareness and linkage of clients; (v) cooperation between HCWs and CHWs, (vi) improved screening infrastructure, (vii) the adoption of the new simplified screening criteria and (viii) training of implementers. The supply-side challenges encountered ranged from disorganized care, limited space, the COVID-19 pandemic, inadequate human resources, inadequate knowledge and expertise, stock out of supplies, delayed maintenance of equipment, to absence of X-ray and GeneXpert machines in some facilities. The demand side challenges ranged from delayed care seeking, inadequate awareness, negative beliefs, fears towards screening, to financial challenges. Suggestions for scaling up ranged from improving service delivery, access to diagnostic equipment and supplies, and infrastructure, to addressing client fears and stigma. CONCLUSION The EXIT-TB package appears to have contributed towards increasing TB case detection and reducing delays in TB treatment in the study settings. Addressing the challenges identified is needed to maximize the impact of the EXIT-TB intervention.
The mediatory role of sense of coherence for mindfulness and stress response among nursing students in Japan: A cross-sectional survey
Authors: Ando Yukako , Ohara Ryoko , Yamauchi Kanako , MacIntyre Richard , Kobayashi Toshio 
Published: January 2023

Abstract

Background
Nursing students experience high levels of stress. Previous studies on nursing students have explored the relationship between mindfulness and stress response, sense of coherence (SOC) and stress response, and mindfulness and SOC. However, whether SOC affects the relationship between mindfulness and stress response is yet to be explored. This study aimed to clarify how SOC affects the relationship between mindfulness and stress response in Japanese nursing students. The results of this study will be useful in considering appropriate mental health interventions for nursing students in the future.
Methods
An anonymous self-administered questionnaire survey using the Mindful Attention Awareness Scale, SOC Scale, and Perceived Stress Scale was conducted, which yielded 130 (74.7%) valid responses. Subsequently, a mediation analysis was performed with stress response as the dependent variable, mindfulness as the independent variable, and SOC as the mediator.
Results
Spearman’s correlation analysis was used to analyze the data and revealed a statistically significant correlation between mindfulness and SOC, mindfulness and stress response, and SOC and stress response. Mediation analysis showed that: the direct effect of mindfulness on stress responses was significant (β = − .40; p < .001). However, the direct effect of mindfulness on stress responses was not significant when SOC was included as a mediator. The bootstrap method was conducted, and the results revealed that the indirect effect of mindfulness on SOC-mediated stress responses was significant (β = − .38; 95% CI = − .47 to − .29, p = .01).
Conclusions
SOC mediated the relationship between mindfulness and stress responses. Improving SOC is necessary to reduce stress responses in nursing students. Additionally, mindfulness should be increased to improve SOC. Future studies should explore enhancing the nursing curricula with mindfulness and SOC training.