bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation of electrolyte behaviour of industrial electrochemical machining
Authors: Moro Luca Del , Sneddon Scott , Gomez-Gallegos Ares A , Lanzetta Michelle , De Silva Anjali K M 
Published: August 2023

Abstract
Development of simulation models for electrochemical machining (ECM) is a widely researched challenge to avoid the traditional trial and error process, with potential resulting advantages in terms of time, cost, and sustainability. To this objective, it is crucial to utilise software that can accurately simulate the complex multiphysics aspects of ECM without being too computationally expensive and with a fast set up. This paper investigates an alternative finite element software to model ECM for industrial production. The specific features of this software make it attractive for industrial applications, and in this work, it is validated as suitable to model the electrolyte characteristics of flow rate and pressure. The model developed is the basis for determining local changes to electrolyte conductivity, current density, and efficiency as a function of gap spacing optimisation in order to achieve the desired geometry with dimensional accuracy and assure process repeatability for industrial production. Simulation results are in agreement with the experimental ECM carried out as part of this work.
Mapping the structure of atherosclerosis biomarker research
from 2012-2022
Authors: Lu Fei , Zhao Yue , Hu Jingqing 
Published: August 2023

Abstract
Background
Atherosclerosis（AS）is a common chronic vascular inflammatory condition. Early detection and diagnosis are important for reducing residual risk.Biomarkers can reveal the diagnosis, prognosis and treatment characteristics. In recent years, a number of studies have been carried out to search for biomarkers with high sensitivity and specificity for the diagnosis of AS, but there are still no such studies. This paper systematically reviews studies related to atherosclerosis biomarkers to provide guidance for further research.
Objective
We conducted a bibliometric analysis of the scientific publications in the last 10 years to identify the key progress, hotspots and emerging trends related to atherosclerosis biomarkers.
Methods
Original studies and reviews regarding to atherosclerosis biomarkers were retrieved from the Web of Science core collection(WoSCC) database. Microsoft Excel 2019,CiteSpace6.1,VOSviewer1.6.16 and bibliometrix were used to map the annual publication,major journals and
performed visualization analysis of keyword co-occurrence,cluster,timeline and keyword burst.
Results
A total of 3,381 articles were finally included. The United States (26.09%) and China (18.87%),accounted for nearly half of the world’s publications. Johns Hopkins University, Harvard Medical School and the University of Washington were the most common publication institutions. Ballantyne christie M, Blaha michael J and Budoff matthew J had the most publications in this field. Articles in this area have been widely published in Atherosclerosis, PlOS One, Journal Of The American Heart Association.All the studies calculated by keyword co-occurrence were divided into
four clusters: “atherosclerosis”, “risk”, “coronary heart disease”and“cardiovascular disease”. Hot topics mainly focused on “Pulse wave velocity”, “C-reactive protein”,“intimal media “Non-coding RNAs” ,“extracellular vesicles” and“neutrophil extracellular traps” were identified as the potential trends.
Conclusions
The research trend of atherosclerosis biomarkers is manifested in the gradual deepening of the research content and the development toward a more detailed level. However, there are still some problems, such as a lack of high-quality research and relatively simple methods.
Effects of a pre-conception care program for women diagnosed with inflammatory bowel disease: A mixed-methods study including a randomized controlled trial
Authors: Lee Young Jin , Kim Yeon Hee , Yang Suk Kyun , Kim Hae Won 
Published: August 2023

Abstract
Background: The purpose of this study was to conduct a pre-conception care education program for women of childbearing age with inflammatory bowel disease (IBD) in Korea and verify its effects on pregnancy knowledge and anxiety, as well as on self-efficacy related to IBD management.
Methods: This was a convergent mixed-methods study, which integrated a randomized controlled trial and interviews. In the quantitative phase, 35 women (17 in the intervention group and 18 in the control group) participated. Those in the intervention group attended a pre-conception care program that included small-group sessions and individual tele-coaching across foursessions. The quantitative research analysis used the generalized estimation equation method to compare changes between the two groups. In the qualitative phase, focus group interviews and tele-coaching were conducted for participants in the intervention group. The qualitative data were analyzed using deductive content analysis.
Results: After the program ended, significant differences were observed between the intervention and control groups for pregnancy knowledge, pregnancy anxiety, and self-efficacy related to IBD management. As a result of qualitative data analysis, the themes derived were “improving IBD awareness related to pregnancy and childbirth,” “relieving anxiety about pregnancy and actively accepting pregnancy,” and “improving confidence in IBD management and awareness related to planned pregnancy.”
Conclusions: It is meaningful that this was the first study to develop a pre-conception care program for women diagnosed with IBD and confirm its effectiveness. The program improved pregnancy-related knowledge, enhanced self-efficacy related to disease management, andreduced anxiety in women with IBD. This program is expected to be suitable for patient counseling and education in clinical practice.
Trial registration: This study was registered on the Korea Clinical Trial Registration (KCT0008022). Retrospectivelyregistered 20/12/2022.
The difference in clinical features of acute acquired concomitant esotropia between adolescents and adults
Authors: Fu Jing , Chen Jiayu , Li Huijian , Hao Jie , Liu Jiawen , Meng Zhaojun , Wang Meixv , Gao Yang 
Published: August 2023

Abstract
Background
To compare the clinical features of acute acquired concomitant esotropia (AACE) between adolescents and adults.
Methods
A monocentric, prospective, and observational cohort study. Clinical features analysis was stratified by age, which was defined as adolescent group (age < 18 years) and an adult group (age ≥ 18 years). Refractive status, the angles of esotropia, angles of deviation at near and far, diplopia, and stereopsis were evaluated between the two groups. P < 0.05 was considered statistically different.
Results
There were 59 patients in the adult group (31 males and 28 females; mean age 29.86 ± 9.64 years), and 42 patients in the adolescent group (29 males and 13 females; mean age 11.57 ± 3.98 years). The age was positively correlated with disease duration (Kendall's tau-b = 0.305), fusional function (Kendall's tau-b = 0.194), and distance stereopsis (Kendall's tau-b = 0.240). The age was negatively correlated with spherical equivalent-right eye(SE-Right) (Kendall's tau-b=-0.305), spherical equivalent-left eye(SE-Left) (Kendall's tau-b=-0.334), the angles of deviation at near (Kendall's tau-b=-0.336) and the angles of deviation at distance (Kendall's tau-b=-0.360). The refractive state of different age groups was significantly different (χ2 = 17.649, p < 0.001). The angles of esotropia in the adolescent group were significantly larger than the adult group (p < 0.001). There were no statistical differences between the two groups for distance stereopsis (χ2 = 2.143, P = 0.143) and near stereopsis (χ2 = 0.671, p = 0. 413).
Conclusions
AACE has diverse clinical features between the adolescent and adult groups. The adult group presented showed more myopia and smaller angles of esotropia compared to the adolescent, which may be related to different pathogenesis and different eye habits.
Decreased telomere length in a subgroup of young individuals with bipolar disorders: replication in the FACE-BD cohort and association with the shelterin component POT1
Authors: Marie-Claire Cynthia , Spano Luana , Godin Ophelia , Lebras Apolline , Courtin Cindie , Laplanche Jean-Louis , Leboyer Marion , Aouizerate Bruno , Lefrere Antoine , Belzeaux Raoul , Courtet Philippe , Olié Emilie , Dubertret Caroline , SCHWAN Raymund , Aubin Valérie , Roux Paul , Polosan Mircea , Samalin Ludovic , haffen emmanuel , Collaborators FondaMental Advanced Centers of Expertise in Bipolar Disorde , Bellivier Frank , Etain Bruno 
Published: August 2023

Abstract
Bipolar disorder (BD) has been associated with premature cellular aging with shortened telomere length (TL) as compared to the general population. We recently identified a subgroup of young individuals with prematurely shortened TL. The aims of the present study were to replicate this observation in a larger sample and analyze the expression levels of genes associated with age or TL in a subsample of these individuals. TL was measured on peripheral blood DNA using quantitative polymerase chain reaction in a sample of 542 individuals with BD and clustering analyses were performed. Gene expression level of 29 genes, associated with aging or with telomere maintenance, was analyzed in RNA samples from a subsample of 129 individuals. Clustering analyses identified a group of young individuals (mean age 29.64 years), with shorter TL. None of the tested clinical variables were significantly associated with this subgroup. Gene expression level analyses showed significant downregulation of MYC, POT1 and CD27 in the prematurely aged young individuals compared to the young individuals with longer TL. After adjustment only POT1 remained significantly differentially expressed between the two groups of young individuals. This study confirms the existence of a subgroup of young individuals with BD with shortened TL. The observed decrease of POT1 expression level suggests a newly described cellular mechanism in individuals with BD, that may contribute to telomere shortening.
A cross-sectional study observing the association of psychosocial stress and dietary intake with gut microbiota genera and alpha diversity among a young adult cohort of black and white women in Birmingham, Alabama
Authors: Knight Rachel , Cedillo Yenni , Judd Suzanne , Baker Elizabeth , Fruge Andrew , Moellering Douglas 
Published: August 2023

Abstract
Background
The relationships between psychosocial stress and diet with gut microbiota composition and diversity deserve ongoing investigation. The primary aim of this study was to examine the associations of psychosocial stress measures and dietary variables with gut microbiota genera abundance and alpha diversity among young adult, black and white females. The secondary aim was to explore mediators of psychosocial stress and gut microbiota diversity and abundance.
Methods
Data on 60 females who self-identified as African American (AA; n = 29) or European American (EA; n = 31) aged 21–45 years were included. Cortisol was measured in hair and saliva, and 16S analysis of stool samples were conducted. Discrimination experiences (recent and lifetime), perceived stress, and depression were evaluated based on validated instruments. Spearman correlations were performed to evaluate the influence of psychosocial stressors, cortisol measures, and dietary variables on gut microbiota genus abundance and alpha diversity measured by amplicon sequence variant(ASV) count. Mediation analyses assessed the mediating role of select dietary variables and cortisol measures on the associations between psychosocial stress, Alistipes and Blautia abundance, and ASV count.
Results
AA females were found to have significantly lower ASV count and Blautia abundance. Results for the spearman correlations assessing the influence of psychosocial stress and dietary variables on gut microbiota abundance and ASV count were varied. Finally, diet nor cortisol was found to partially or fully mediate the associations between subjective stress measures, ASV count, and Alistipes and Blautia abundance.
Conclusion
In this cross-sectional study, AA females had lower alpha diversity and Blautia abundance compared to EA females. Some psychosocial stressors and dietary variables were found to be correlated with ASV count and few gut microbiota genera. Larger scale studies are needed to explore the relationships among psychosocial stress, diet and the gut microbiome.
Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
Authors: Eskandari-Sedighi Ghazaleh , Crichton Madeline , Zia Sameera , Gomez Erik , Laurent Chris D. St. , Cortez Leonardo M. , Patel Zain H. , Sidhu Gaurav , Sarkar Susmita , Aghanya Vivian , Sim Valerie L. , Tan Qiumin , Julien Olivier , Plemel Jason R. , Macauley Matthew S 
Published: August 2023

Abstract
Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility through a single nucleotide polymorphism that modulates mRNA splicing, skewing protein expression from a long protein isoform (CD33M) to a short isoform (CD33m). Understanding how human CD33 isoforms differentially impact microglial cell function in vivo has been challenging due to functional divergence of CD33 between mice and humans. We address this challenge by studying transgenic mice expressing either of the human CD33 isoforms crossed with the 5XFAD mouse model of amyloidosis and find that human CD33 isoforms have opposing effects on the response of microglia to amyloid-b (Aβ) deposition. Mice expressing CD33M have increased Aβ levels, more diffuse plaques, fewer disease-associated microglia, and more dystrophic neurites compared to control 5XFAD mice. Conversely, CD33m promotes plaque compaction and microglia-plaque contacts, and minimizes neuritic plaque pathology, highlighting an AD protective role for this isoform. Protective phenotypes driven by CD33m are detected at an earlier timepoint compared to the more aggressive pathology in CD33M mice that appears at a later timepoint, suggesting that CD33m has a more prominent impact on microglia cell function at earlier stages of disease progression. In addition to divergent roles in modulating phagocytosis, scRNAseq and proteomics analyses demonstrate that CD33m+ microglia upregulate nestin, an intermediate filament involved in cell migration, at plaque contact sites. Overall, our work provides new functional insights into how CD33, as a top genetic susceptibility factor for AD, modulates microglial cell function.
Matching with community sports facilities in a national fitness environment based on ant colony algorithm
Authors: Guo Wenbin , Tian Tian 
Published: August 2023

Abstract
The advancement of cultural awareness, the pressure of work is getting higher and higher. This living state has buried many hidden dangers to people's physical and mental health. These "hidden dangers" and various diseases caused by modern lifestyles have made modern physical and mental health, and their enthusiasm for participating in sports is also rising. Under the background of national fitness, all localities have actively responded to the call of the state to build civic sports facilities that serve the masses. However, with the advancement of my country's economic level, the national fitness industry has entered a new era. People are no longer satisfied with having an activity venue, but have an all-round experience of social, leisure, sports and other functions and spaces. become a common pursuit of citizens. Outdoor community sports facilities emerge as the times require, and various sports fitness equipment, sports venues, entertainment and health integration facilities are constantly emerging, forming a modern national fitness sports pattern with community sports as the main feature. Based on the above problems ant colony algorithm theory, this paper proposes a design strategy for the coordination of community sports facilities in a national fitness environment, so as to obtain an outdoor community sports fitness venue suitable for mass physical fitness.
Roles of Different Hydroperiod Habitats in Neighboring Rice Paddies and Biotopes in Supporting an Endangered Pond Frog Population in Japan
Authors: Naito Risa S , Sakai Masaru , Natuhara Yosihiro , Morimoto Yukihiro 
Published: August 2023

Abstract
The Nagoya Daruma pond frog Pelophylax porosus brevipodus (formerly Rana porosa brevipoda) requires a wet environment year-round, but such habitats have generally been lost due to improved rice paddy drainage such that the frog populations have been decreasing. There have been attempts to create permanent pools in rice paddy areas to help the populations recover, but the basic life history patterns and population dynamics in both environments have not been well studied. We captured frogs in rice paddies and adjacent biotopes. Using capture–mark–recapture data with 816 marked individuals, we compared frog demographics and population structure using a Jolly–Seber POPAN model. Constructed biotopes had conditions favoring long-term persistence. For example, biotopes had larger frogs of both sexes than rice paddies. The ratio of juveniles to adults was lower in biotopes than rice paddies. By contrast, rice paddies were an important habitat for breeding and producing new frogs.The two habitats complemented each other to support the local frog population. Because P. p. brevipodus is now exclusively distributed in rice paddy areas, the creation of permanent pools is a feasible way to improve habitat quality, especially in modernized rice paddy areas with few permanent lentic habitats.
Exploring the Potential for Bamboo Agroforestry through a Value Chain Approach in Thailand, using Cloud-based Data Management on Google Earth Engine
Authors: Amatyakul Wasita , Orozco Sebastian , Bunschoten Raoul 
Published: August 2023

Abstract
The global construction sector consumes almost half of the world's total material production footprint, implying it is the highest single-category material footprint across the global economy. In the search for nature-based alternatives, bamboo grass can become a mainstream building material in the global tropical belt due to significantly shorter rotation times compared to softwood or hardwood species. To determine bamboo potential within a value-chain work frame, the first step is to evaluate the potential land for cultivation. Technically driven soil selection, with optimal climatic conditions, can generate culms taller than 20 m or, on the contrary, culms of a maximum of 6 to 7 m in height. The correct choice of soil also favors the plantation owner since faster plant development will be observed; the plantation will show a higher number of culms, larger diameters, cheaper production, and shorter times until plant maturity, thus requiring less time to recover the initial investment. This research presents a remote-sensing-based tool for surveying and exploring bamboo agroforestry potential over the entire national territory of Thailand based on climatic conditions, altitude, topography, existing land cover, and soil characteristics (texture and acidity). Through the implementation of the research, a total amount of 345,838 km² with viable growth conditions was discovered. 45,968 km² (13.29%) show basic compatibility levels, 242,198 km² (70.03%) show intermediate levels and 57,672 km² (16.68%) present optimal growth conditions. The corresponding regions were located on an interactive geoportal with a 100 m-per-pixel resolution and the ability to benchmark the individual selection criteria.
Early Parameter to Detect the Resolution of Pediatric Diabetic ketoacidosis
Authors: Su Ya-Ting , Lo Fu-Sung , Hsia Shao-Hsuan , Lin Jainn-Jim , Chan Oi-Wa , Yen Chen-Wei , Chiu Chun-Che , Chang Han-Pi , Lee En-Pei 
Published: August 2023

Abstract

Objective
Since only a few studies have analyzed the incidence of hyperchloremia in pediatric diabetic ketoacidosis (DKA) after treatment and analyzed the time it takes for different parameters to reach DKA resolution, the present study aimed to analyze the incidence of hyperchloremia and compare the time required to reach DKA resolution with different parameters.
Methods
A chart review of patients diagnosed with DKA and aged < 18 years was conducted. DKA was defined as serum glucose ≧ 200 mg/dL, venous pH (vpH) < 7.30, serum bicarbonate < 15 mmol/L, and presence of ketonemia, or ketonuria. Electrolytes and blood gases were recorded at 6-h intervals after treatment initiation.
Results
Overall, 84 patients were admitted because of DKA. The initial biomedical parameters in the emergency department were as follows: median glucose, 497 mg/dL; vpH, 7.1; serum HCO3, 6.6 mmol/L; anion gap (AG), 24.7 mmol/L; and ketone, 5.7 mmol/L. After treatment, the incidence of hyperchloremia increased progressively from 15.4% at treatment initiation to 80% at 18 h. The median time to resolution defined by AG ≦ 12 mmol/L was 12 h, which was significantly faster than the recovery of vpH > 7.3 (median time, 17 h) and HCO3 > 15 mmol/L (median time, 18 h). Approximately 63 (75%) patients reached the endpoints of AG ≦ 12 mmol/L prior, 14 (16.6%) patients reached the endpoints of vpH ≧ 7.3 prior, 7 (8.4%) patients reached the endpoints of HCO3 > 15 mmol/L prior.
Conclusions
Hyperchloremic metabolic acidosis (HMA) was a common entity in pediatric DKA following treatment. The median time of AG closure was approximately 12 h and was the parameter that can detect DKA resolution at a faster rate, i.e., approximately 5, and 6 h faster than the normalization of vpH and HCO3, respectively. Future studies were warranted to use AG ≦ 12 mmol/L as the endpoint of DKA treatment and check if the treatment course and incidence of HMA could be reduced.
Establishment and validation of a risk-score prognostic model based on immunogenic cell death related genes for hepatocellular carcinoma in the Asian population
Authors: Feng Zhengyang , Wang Yanjie , Liang Yong , Gu Xuhao , Yang Yinyin , Zhang Yusong , Peng Qiliang 
Published: August 2023

Abstract
Background:Hepatocellular carcinoma (HCC) is the most common form of liver cancer, which is known to be characterized by poor therapeutic effects and prognosis. The etiology of HCC is regionally variable, with hepatitis B virus (HBV) being the leading cause in most of Asia. Immunogenic cell death (ICD) is a form of cell death. Many studies have shown that ICD-related processes are closely associated with the treatment of HCC. Through this study, we tried to investigate the significance of ICD-related genes in the Asian HCC population and expected to provide new ideas for the treatment of HCC.
Methods: We first downloaded transcriptomic data and clinical data related to HCC in Asian population from TCGA database. Then, we divided the samples into different subgroups based on the expression of ICD-related genes and performed tumor microenvironment differential analysis and enrichment analysis. In addition, we randomly divided the samples into train as well as test groups, and then constructed and validated an ICD gene-based risk-prognosis model for the Asian HCC population.
Results: We divided the Asian HCC samples into two subgroups, including the ICD high expression and ICD low expression groups. We found that in the ICD low expression group, there was less immune cell and stromal cell infiltration, higher tumor purity, and better prognosis. We then also constructed a 5-gene risk-score prognostic model, including BAX, CASP8, HMGB1, HSP90AA1 and IL6, which was effective in predicting the prognosis of the Asian HCC population.
Conclusion: Our study provides new insights into the role of ICDs in Asian HCC populations. The risk-score prognostic model based on five ICDs can assess the prognosis of Asian HCC populations, which also has the potential to be new targets for HCC treatment.