bluuebunny/crossref_metadata_2025_split huggingface dataset:
The maximal contrast-enhanced range of CT for differentiating the WHO pathological subtypes and risk subgroups of thymic epithelial tumors
Authors: Yu Chunhai , Li Ting , Yang Xiaotang , Xin Lei , Zhao Zhikai , Yang Zhao , Zhang Ruiping 
Published: July 2023

Objective:
To explore the value of maximal contrast-enhanced (CEmax) range using contrast-enhanced CT (CECT) imaging in differentiating the pathological subtypes and risk subgroups of thymic epithelial tumors (TETs).

Methods:
The pre-treatment-CECT images of 319 TET patients from May 2012 to November 2021 were analyzed retrospectively. The CEmax was defined as the maximum difference between the CT value of the solid tumor on pre-contrast and contrast-enhanced images. The mean CEmax value was calculated at three different tumor levels.

Results:
There was a significant difference in the CEmax among the eight main pathological subtypes [types A, AB, B1, B2, and B3 thymoma, thymic carcinoma (TC), low-grade neuroendocrine tumor (NET) and high-grade NET] (p &lt; 0.001). Among the eight subtypes, the CEmax values of types A, AB, and low-risk NET were higher than those of the other subtypes (all p &lt; 0.001), and there was no difference among types B1–B3 and high-risk NET (all p &gt; 0.05). There was no difference for CEmax values between NET and TC (p = 0.491). For the risk subgroups, the CEmax of TC (including NET) was 35.35 ± 11.41 HU, which was lower than that of low-risk thymoma (A and AB) (57.73±21.24 HU) (P &lt; 0.001) and was higher than that of high-risk thymoma (B1–B3) (27.37±8.27 HU) (P &lt; 0.001). The CEmax cut-off values were 38.5 HU and 30.5 HU respectively (AUC: 0.829 and 0.712; accuracy, 72.4% and 67.7%).

Conclusion:
The tumor CEmax on CECT helps differentiate the pathological subtypes and risk subgroups of TETs.

Advances in knowledge:
In this study, an improved simplified risk grouping method was proposed based on the traditional (2004 edition) simplified risk grouping method for TETs. If Type B1 thymoma is classified as high-risk, radiologists using this improved method may improve the accuracy in differentiating risk level of TETs compared with the traditional method.
Comparative evaluation of platelet rich fibrin matrix (PRFM) membrane and platelet rich fibrin (PRF) membrane using the vestibular incision subperiosteal tunnel access (VISTA) approach technique for the treatment of multiple gingival recession in humans: A double-blind, parallel-group, randomized controlled clinical trial
Authors: Hassan Safiya , Dhadse Prasad , Bajaj Pavan , Sethiya Kiran , Subhadarsanee Chitrika , Oza Ranu 
Published: July 2023

Background: In this evolutionary era of dentistry, newer techniques have evolved for complete coverage of multiple recession defects (MRDs). Since 2012, MRDs have been treated using the vestibular incision subperiosteal tunnel access (VISTA) approach and a variety of regenerating membranes with varying degrees of success. Platelet‑rich fibrin matrix (PRFM) membrane has shown a robust release of growth factors and was known to enhance the healing process. Thus, in this study we have evaluated the effectiveness of platelet-rich fibrin matrix (PRFM) with that of platelet-rich fibrin (PRF) membrane using the vestibular incision subperiosteal tunnel access (VISTA) technique in Miller Class I and II multiple gingival recession defects. Methods: This randomized, parallel designed, controlled, clinical study was conducted in 20 subjects (10 male and 10 female) having class I/II MGR defects either buccally or labially. The test group was treated with VISTA and PRFM membrane while the control group was treated with VISTA and PRF membrane. The clinical measurements such as plaque index, papillary bleeding index, probing pocket depth, relative attachment level (RAL) and relative gingival marginal level (R-GML), width of keratinized gingiva (WKG), gingival recession (REC) and gingival thickness (GT) were measured at baseline, three and six months. A Student’s paired t-test was utilized to analyse data from the day of surgery to six months. Results: Ten patients in the test group (89.23±15.04) and 10 patients in the control group (85.06±17.71) showed marked root coverage compared to baseline. Conclusions: Both test and control groups showed statistically significant enhancement in root coverage. However, no statistically significant difference was found when a comparison was made between the two groups in terms of PD, relative RAL, R-GML and REC reduction, gain in WKG, and increase in GT. Trial registration: CTRI/2021/07/035240, registered 29 July 2021.
The revitalization of endangered heritage buildings in developing countries: A decision-making framework for investment and determining the highest and best use in Egypt
Authors: Selim Mohanned , Abulnour Adham , Eldeeb Sally 
Published: July 2023

Background: Egypt's major cities have been losing heritage and historical buildings due to neglect and misuse, prompting non-governmental organizations, academic institutions, and researchers to advocate for adaptive reuse strategies to preserve the cities' heritage and identity. Adaptive reuse involves changing, modifying, or reusing a space based on community needs, business model, location, and proximity to facilities and services. Heritage buildings offer many tangible and intangible benefits that enhance financial returns, making them challenging but feasible and attractive for investors who value authenticity, uniqueness, and sustainability. Methods: This study examines how market value, acquisition opportunities, target clients, age groups, and socioeconomic status affect decision-making. A comparative analysis of three buildings in the Egyptian cities of Alexandria and Cairo is utilized to establish development guidelines and decision-making parameters that significantly impact project design and building functions to determine the highest and best use. In order to complete this study, AutoCAD by Autodesk was used for 2D drawings, SketchUp by Trimble for 3D models, Adobe Photoshop for diagram presentation, and Microsoft Office for tables and diagrams. Results: The comparative analysis provided valuable insights into the adaptive reuse of heritage buildings in developing countries. Findings highlighted how cultural heritage preservation could foster socioeconomic development. Key success factors included stakeholder and community engagement, financial viability, and architectural compatibility. The decision-making framework provides a practical tool for evaluating heritage building reuse. Conclusions: The analysis illustrates successful reuse strategies and considerations. Decision-making frameworks and tools offer practical guidance for future investments and decisions. These findings affect heritage conservation and urban development policymakers, planners, and investors. Stakeholders can make informed decisions and implement strategies to preserve cultural and environmental value by realizing challenges and opportunities. This study hopes to inspire more research and help preserve and revitalize heritage buildings in developing countries, preserving their cultural and socioeconomic value.
Linking policy and practice in monitoring socially responsible research and innovation (RRI): A conceptual framework to evaluate progress through the UNESCO-led Recommendation on Science and Scientific Researchers
Authors: Jensen Eric Allen 
Published: July 2023

This paper sets out a high-level conceptual framework for monitoring the development of socially responsible research and innovation (RRI) systems linked to the global policy instrument called ‘the Recommendation on Science and Scientific Researchers’ (RSSR). RRI is an umbrella concept, rooted in EU policy and research, that encompasses a range of topics that overlap directly with the RSSR. These topics include social inclusion in scientific research, improved scientific transparency and governance and expanded public engagement with science. The RSSR is an international accord ratified by 195 United Nations Educational Scientific and Cultural Organization (UNESCO) Member States in 2017, updating an earlier version of the instrument. This UNESCO-led initiative offers a globally inclusive and agreed structure for advancing RRI-related principles. A key feature of the RSSR initiative is its permanent structure of quadrennial monitoring to assess implementation of its principles. Here, a conceptual framework is presented to clarify the specific dimensions of RRI embedded in the 10 key priority areas for this quadrennial monitoring process. The paper explicates these dimensions and the underpinning policy language from the 2017 recommendation with the aim of supporting UNESCO Member States and research stakeholders globally to design appropriate evaluation methods. This conceptual framework is intended to support development of globally aligned measurement of RRI policy and practice that allows research and policy stakeholders from each world region to learn from each other. Fostering mutual learning on a global scale will help to enable evidence-based practice in the context of RRI to improve outcomes and mitigate the limitations of well-meaning but ineffective policies and practices.
Towards equality: gender representation at the Royal College of Radiologists’ Annual Scientific Meeting 2014-2021
Authors: Gibson Lorna M. , Wood Kayleigh L. , Wardlaw Joanna M. 
Published: July 2023

Background: Conferences facilitate career advancement, but gender imbalances in public fora may negatively impact both women and men, and society. We aimed to describe the gender distribution of presenters at the UK’s 2014-2021 Royal College of Radiologists’ (RCR) Annual Scientific Meeting. Methods: We extracted data on presenter name, role and session type from meeting programmes. We classified gender as male or female using names, records or personal pronouns, accepting the limitations of these categories. We classified roles by prestige: lead, other (speakers and workshop faculty), proffered paper or poster presenters. We calculated odds ratios (OR) and 95% confidence intervals (CI) for associations between gender and binary outcomes using logistic regression. Results: Women held 1,059 (37.5%) of 2,826 conference roles and presented 9/27 keynotes. Compared to men, women were less likely to hold other roles such as speakers and workshop faculty (OR 0.72 95% CI 0.61-0.83), and more likely to present posters (OR 1.49 95% CI 1.27-1.76). There were 60 male-only and eight women-only multi-presenter sessions. Sessions led by women had higher proportions of women speakers. The odds of roles being held by women increased during online meetings during COVID in 2020 and 2021 (OR 1.61, 95% CI 1.36-1.91) compared to earlier years. Conclusion: The proportion of women presenters and keynote speakers reflects that of RCR membership, but not of wider society. Disadvantage starts from the earliest career stages, prejudicing career opportunities. Efforts to improve inclusion and diversity are needed; focusing on lead roles and hybrid online/in-person formats may accelerate change.
Isolated periodontal pockets: a clinical review
Authors: Ramachandra Srinivas Sulugodu , Gupta Vivek Vijay , Woodford Valerie , Malhotra Neeraj 
Published: July 2023

An isolated periodontal pocket is a perplexing clinical entity that usually poses a diagnostic challenge to the oral health professional. Although periodontal pockets are easy to detect, they can be easily missed during a routine clinical examination. The broad range of aetiological factors that can result in an isolated periodontal pocket makes identifying the cause difficult. The aetiology can be as simple as an overhanging restoration or food impaction due to open interproximal contacts, to more complex and uncommonly occurring presentations, such a palato-radicular groove or cemental tears. Although previous classifications proposed by the American Academy of Periodontology and European Federation of Periodontology have discussed this topic under different headings, an explicit classification on isolated periodontal pockets based on aetiology is currently missing. Isolated periodontal pockets are easily undiagnosed, with associated cases presenting with substantial destruction necessitating complex multidisciplinary treatment. This article highlights the various causes of an isolated periodontal pocket, and provides a systematic and easy clinical aetiology-based classification. The proposed classification categorizes isolated periodontal pockets into those occurring due to: (1) developmental anomalies of the teeth; (2) iatrogenic causes; and (3) pathological conditions. Further studies are essential to validate this classification. CPD/Clinical Relevance: Early detection of easily missed isolated periodontal pockets is of clinical value during initial screening to avoid delayed diagnosis and treatment.
Effect of lycopene and metformin combination on phagocytosis, glycemic control, and oxidative stress in rats with type 2 diabetes
Authors: Sianturi Medina , Susilaningsih Neni , Nugroho Heri , Suci Nyoman , Kristina Tri Nur , Suryani Maria 
Published: July 2023

BACKGROUND Hyperglycemia and oxidative stress cause phagocytosis dysfunction in patients with diabetes. A combination of lycopene and metformin can reduce oxidative stress and blood glucose. This study aimed to determine the effect of combined lycopene and metformin on phagocytosis function, glycated hemoglobin A1c (HbA1c), nitric oxide (NO), reactive oxygen species (ROS), and advanced glycation end products (AGEs).
METHODS A randomized controlled study was conducted in rats at the Center for Food and Nutrition Studies, Universitas Gadjah Mada, Yogyakarta, Indonesia, from August to September 2022. 30 rats were divided into control (n = 5) and type 2 diabetes mellitus (T2DM) (n = 25) groups. Rats in the T2DM group were induced by a high-fat diet combined with streptozotocin-nicotinamide. The 25 rats were then divided into five subgroups: 1 ml coconut oil (DM), 250 mg/kg metformin in 1 ml coconut oil (DMet), 250 mg/kg metformin + 10 mg/kg lycopene in 1 ml coconut oil (DML-10), 250 mg/kg metformin + 20 mg/kg lycopene in 1 ml coconut oil (DML-20), and 250 mg/kg metformin + 40 mg/kg lycopene in 1 ml coconut oil (DML-40). Treatments were administered daily for 4 weeks. The macrophage phagocytosis index (PI), HbA1c levels, ROS, NO, and AGEs serum were evaluated.
RESULTS There was a significant difference in the PI, HbA1c, NO, ROS, and AGEs between the groups (p<0.001). The DML-20 and DML-40 groups had significantly increased PI and decreased NO, ROS, and AGEs levels than metformin alone (p<0.05).
CONCLUSIONS Lycopene combined with metformin could improve phagocytosis function, glycemic control, and oxidative stress.
Spatial predictive risk mapping of lymphatic filariasis residual hotspots in American Samoa using demographic and environmental factors
Authors: Cadavid Restrepo Angela M. , Martin Beatris M. , Fuimaono Saipale , Clements Archie C. A. , Graves Patricia M. , Lau Colleen L. 
Published: July 2023

Background
American Samoa successfully completed seven rounds of mass drug administration (MDA) for lymphatic filariasis (LF) from 2000–2006. The territory passed the school-based transmission assessment surveys in 2011 and 2015 but failed in 2016. One of the key challenges after the implementation of MDA is the identification of any residual hotspots of transmission.

Method
Based on data collected in a 2016 community survey in persons aged ≥8 years, Bayesian geostatistical models were developed for LF antigen (Ag), and Wb123, Bm14, Bm33 antibodies (Abs) to predict spatial variation in infection markers using demographic and environmental factors (including land cover, elevation, rainfall, distance to the coastline and distance to streams).

Results
In the Ag model, females had a 26.8% (95% CrI: 11.0–39.8%) lower risk of being Ag-positive than males. There was a 2.4% (95% CrI: 1.8–3.0%) increase in the odds of Ag positivity for every year of age. Also, the odds of Ag-positivity increased by 0.4% (95% CrI: 0.1–0.7%) for each 1% increase in tree cover. The models for Wb123, Bm14 and Bm33 Abs showed similar significant associations as the Ag model for sex, age and tree coverage. After accounting for the effect of covariates, the radii of the clusters were larger for Bm14 and Bm33 Abs compared to Ag and Wb123 Ab. The predictive maps showed that Ab-positivity was more widespread across the territory, while Ag-positivity was more confined to villages in the north-west of the main island.

Conclusion
The findings may facilitate more specific targeting of post-MDA surveillance activities by prioritising those areas at higher risk of ongoing transmission.
LUPA NH:
Authors: Carneiro Jéssica de , Silva Alan Milhomem da , Eduardo Tiago , Lima Júnior Walter Teixeira 
Published: July 2023

O presente paper visa trazer, como comunicação científica, o case do projeto de Jornalismo Hiperlocal Lupa NH, este tido enquanto relato de experiência na busca do desenvolvimento de tecnologias sociais voltadas a processos comunicacionais de base comunitária. O projeto atua no bairro de Novo Horizonte, em Macapá (AP), com a perspectiva de coletar informações e gerar base de dados a partir da geolocalização, por meio de aplicativo para dispositivos móveis e com a visualização dos dados coletados via portal de transparência. O objetivo é promover autonomia cidadã nos fluxos de comunicação entre moradores(as), estudantes e professores da escola básica e do curso de Jornalismo da Universidade Federal do Amapá (Unifap), bem como abrir possibilidades de diálogo entre a comunidade com o poder público. A iniciativa pretende ainda apresentar soluções e, com isso, empoderar habitantes da região para o enfrentamento de problemas, como os de infraestrutura urbana, recorrentes na localidade, gerando visibilidade às demandas do bairro internamente e também na mídia local.
Hyperglycemia and Glycemic Variability in Hospitalized Patients and its Impacts on Morbidity and Mortality: An Integrative Literature Review
Authors: Maia Larissa Peixoto , Feitosa Pedro Walisson Gomes , Mauriz Patrícia Cristiane Bezerra Tavares , Maia Lorena Peixoto , Silva Melina Maria Batista , Rodrigues Paloma Nóbrega 
Published: July 2023

The constant change in plasma glucose is related to increased mortality, morbidity, length of stay and complications in patients in the hospital context. Dysglycemia increases the risk of infections, thrombosis and leads to slower wound healing. The main objective of this work was to carry out a literature review of the literature regarding the assessment and management of glycemic variability in hospitalized patients. An electronic search was performed for articles published in journals indexed through the PubMed database, using the following combination of descriptors verified in the MESH database: “Glycemic Control” OR “Blood Glucose” AND “Patient Readmission”, AND “Inpatients” OR “Hospitalization”. Studies published between January and September 2022 were admitted. People with diabetes mellitus (DM) are more likely to be hospitalized due to comorbidities and complications specific to their disease. Hyperglycemia in hospitalized patients, even in the absence of a known diagnosis of diabetes, is associated with higher mortality and longer mean length of stay.
A split special Lagrangian calibration associated with frame vorticity
Authors: Salvai Marcos 
Published: July 2023

Abstract
Let M be an oriented three-dimensional Riemannian manifold. We define a
notion of vorticity of local sections of the bundle

SO
⁢

(
M
)

→
M

{\mathrm{SO}(M)\rightarrow M}

of all its positively oriented orthonormal tangent
frames. When M is a space form, we relate the concept to a
suitable invariant split pseudo-Riemannian metric on

Iso
o

⁢

(
M
)

≅

SO
⁢

(
M
)

{\mathrm{Iso}_{o}(M)\cong\mathrm{SO}(M)}

: A local section has positive vorticity if and only
if it determines a space-like submanifold. In the Euclidean case we find
explicit homologically volume maximizing sections using a split special
Lagrangian calibration. We introduce the concept of optimal frame vorticity and
give an optimal screwed global section for the three-sphere. We prove that
it is also homologically volume maximizing (now using a common one-point
split calibration). Besides, we show that no optimal section can exist in
the Euclidean and hyperbolic cases.
Assessment of the impact of γ-irradiation on the piperine content and microbial quality of black pepper
Authors: Bektashi Nora Limani , Mladenoska Irina , Popovska Olga , Dimitrovski Darko , Spasevska Hristina , Reka Arianit A. , Mašić Slobodan 
Published: July 2023

Abstract
The major bioactive component of black pepper (Piper nigrum) is piperine which has demonstrated beneficial therapeutic properties. The purpose of this research was to investigate the effects of different irradiation doses on the content of piperine in black pepper. Samples were irradiated with 60Co γ-rays (at absorbed doses of 0.5, 1, 3, 5, 7, 10, and 12 kGy). Thin-layer chromatography (TLC) and UV–Vis spectrophotometry methods were used for measuring the piperine content in the samples. TLC was performed using three mobile phases (1. toluene:ethyl acetate, 7:3 v/v; 2. acetone:n-hexane, 6:4 v/v; 3. toluene:methanol, 8.5:1.5 v/v) and the retention factor (R
f) value for piperine was equal to 0.66, 0.94, and 0.67, respectively. The content of piperine in γ-irradiated samples of black pepper was found to be between 0.04 and 1.05% w/w from the spectrophotometry analyses. Irradiation slightly decreased the piperine content of black pepper. It was found that piperine crude yield from black pepper was from 1.10 (the unirradiated sample) to 1.69, 1.07, 0.60, 0.90, 0.30, 1.20, 0.80% for irradiated samples, respectively. Microbiological analyses were performed with standard plate count method, which resulted in a decreasing number of the total cell count of microbial cells with increasing the radiation dose. Treatment with irradiation reduced the population of bacteria by 4 logs.
Boundary regularity of minimal graphs in the hyperbolic space
Authors: Han Qing , Jiang Xumin 
Published: July 2023

Abstract
F.-H. Lin (1989) studied minimal graphs of the Dirichlet problem
in the hyperbolic space and proved that any such minimal graph has the same global regularity
as the boundary if
the dimension of the minimal graph is even and that there is an obstacle to the higher regularity
if the dimension is odd. We discuss the odd-dimensional case and study how the higher regularity is
obstructed.
We introduce the logarithmic distance to the boundary as an additional independent self-variable and establish concise boundary regularity for
the minimal graph.
On quadratically enriched excess and residual intersections
Authors: Bachmann Tom , Wickelgren Kirsten 
Published: July 2023

Abstract
We use recent duality results of Eisenbud and Ulrich to give tools to study quadratically enriched residual intersections when there is no excess bundle.
We use this to prove a formula for the Witt-valued Euler number of an almost complete intersection.
We give example computations of quadratically enriched excess and residual intersections.
Collapsing and noncollapsing in convex ancient mean curvature flow
Authors: Bourni Theodora , Langford Mat , Lynch Stephen 
Published: July 2023

Abstract
We provide several characterizations of collapsing and noncollapsing in convex ancient mean curvature flow, establishing in particular that collapsing occurs if and only if the flow is asymptotic to at least one Grim hyperplane. As a consequence, we rule out collapsing singularity models in

(

n
-
1

)

{(n-1)}

-convex mean curvature flow (even when the initial datum is only immersed). Explicit counterexamples show that

(

n
-
1

)

{(n-1)}

-convexity is optimal. We are also able to rule out collapsing singularity models for suitably pinched solutions of higher codimension.