bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between 72-hour ST segment decline and prognostic outcomes in patients with acute fulminant myocarditis complicated by ST-segment elevation on venoarterial extracorporeal membrane oxygenation support
Authors: He Wenyi , Ye Lin , Deng Guolan 
Published: January 2023

Abstract
Objective
To compare differences in ST-segment decline between surviving and non-surviving patients with acute fulminant myocarditis (AFM) complicated by ST-segment elevation supported by venoarterial extracorporeal membrane oxygenation (VA-ECMO).
Methods
We retrospectively analyzed the clinical data from patients with AFM complicated by ST elevation receiving VA-ECMO support in our hospital between January 2017 and December 2019. Based on survivorship status at discharge, patients were separated into survivor and non-survivor groups. The degree of decrease in the sum of ST-segment elevation amplitudes (∑STE) at 24 h, 48 h, and 72 h was then compared between these groups to assess the prognostic relevance of these parameters as a noninvasive electrophysiological cardiac biomarker.
Results
In total, 19 AFM patients that underwent VA-ECMO support were included in this study cohort. The mean age of these patients was 35, and 14 survived treatment (73.7%), while 5 did not. Following VA-ECMO support, the 72h∑STE in the survivor group was 0.09 ± 0.093 mm, with this value being significantly lower than that observed in the non-survivor group (0.24 ± 0.270 mm). Significant differences in both 48h∆∑STE (0.73 ± 0.298 vs. 0.65 ± 0.112, P < 0.05) and 72h∆∑STE (0.81 ± 0.353 vs. 0.78 ± 0.045, P < 0.01) were observed when comparing the survivor and non-survivor groups, and the decrease was significantly greater in the survivor group relative to the non-survivor group.
Conclusions
VA-ECMO can effectively treat cardiac arrest or cardiogenic shock resulting from AFM. The magnitude of ST-segment retreat may be associated with patient recovery following myocardial injury, potentially predicting prognostic outcomes together with other indicators in a manner that can guide treatment-related decision-making or inform ECG frequency.
Construction and Validation of Nomogram Prognostic Model for Predicting Survival in Hepatoblastoma Patients: A Population-Based Study
Authors: Liu Chunxiang , Wang Song , Liu Yong , Guo Zheng , Li Rui , Wang Yuchao , Sun Wei , Ji Fulong , Sun Daqing 
Published: January 2023

Abstract
Background
For patients with hepatoblastoma (HB), current staging system is not accurate in predicting survival outcomes. The aim of this study was to develop two accurate survival prediction models to guide clinical decision making.
Methods
A retrospective analysis of 424 HB patients was performed from 2004 to 2015 using the Surveillance, Epidemiology and End Results (SEER) database. Univariate and multivariate Cox regression analysis was used to screen for variables. The identified variables were used to build survival prediction model. The performance of the nomogram models was assessed based on the concordance index (C-index), calibration plot, and receiver operating characteristic (ROC) curve.
Results
The Cox regression analysis identified six variables affecting overall survival (OS) in HB patients, including race, tumor size, lymph node involvement, distant metastases, surgery and chemotherapy. And the Cox regression analysis identified five variables including race, lymph node involvement, distant metastases, surgery and chemotherapy that affect cancer-specific survival (CCS) in HB patients. In the training cohort, the C-index of the nomogram in predicting the OS was 0.791[95% confidence intervals (95% CI): 0.717–0.865], CSS was 0.805(95% CI: 0.728–0.882). In the validation cohort, the C-index of the nomogram in predicting the OS was 0.712 (95% CI: 0.511–0.913), the CSS was 0.751 (95% CI: 0.566–0.936). In the training cohort, the area under the receiver operator characteristics curve (AUC) values of the nomogram in prediction of the 1, 3, and 5-year OS were 0.842 (95% CI: 0.739–0.944), 0.759 (95% CI: 0.670–0.849), and 0.770 (95% CI: 0.686–0.852), respectively. In the validation cohort, the AUC values for prediction of the 1, 3, and 5-year OS were 0.920 (95% CI: 0.806–1.034), 0.863 (95% CI: 0.750–0.976), and 0.844 (95% CI: 0.721–0.967), respectively.
Conclusion
Two nomogram models were developed and validated in this study which provided accurate prediction of the OS and CSS in HB patients. The constructed models can be used for predicting survival outcomes and guide treatment for HB patients.
The Effect of Direct Oral Anticoagulant Therapy (DOACs) On Oral Surgical Procedures: A Systematic Review
Authors: Darwish Ghassan 
Published: January 2023

Abstract
Purpose: Direct oral anticoagulants (DOACs) were developed to overcome the drawbacks of oral anticoagulants. However, not much has been discussed on the perioperative management of patients on DOACs during oral surgical procedures. Thus, we aim to determine the risk of perioperative and postoperative bleeding during oral surgical procedures in patients on DOACs.
Methodology: A detailed literature search was performed to find potentially relevant studies using Cochrane Library, Clinical Key, ClinicalTrials.gov, Google Scholar, Ovid, ScienceDirect, and Scopus. Every article available for free in the English literature for the past 5 years, between 2018 -2022 was searched.
Results: A total of 1091 abstracts were selected through search strategy across various search engines. Based on inclusion and exclusion criteria, eight clinical studies using DOACs as anticoagulants or studies comparing patients with and without DOACs under oral surgery procedures were found. The results were inconsistent and varied with few studies recommending DOACs administration with bare minimum reported complications and remaining finding no statistically significant difference between discontinuation or continuation of drugs, especially across basic dental procedures.
Conclusion: Within the limitation of the study, it can be concluded that minor oral surgical procedures are safe to perform in patients on DOAC therapy. However, the continuation or discontinuation of DOACs in patients undergoing oral surgical procedures remains controversial and requires further studies to extrapolate the results.
An assessment of the green innovation, environmental regulation, energy consumption, and CO2 emissions dynamic nexus in China: Fresh insights based on the GMM model
Authors: Jiang Hang , Sun TaiPeng 
Published: January 2023

Abstract
Green innovation is a critical support to combat climate change arising from greenhouse gas emissions generated by energy consumption. It is an essential way to achieve resource storage, carbon emissions reduction, and sustainable development goals in China. Based on an environmental framework defined as the Stochastic Impacts by Regression on Population, Affluence, and Technology (STIRPAT) model, this study aimed to empirically check the impact of green innovation (GI), per capita GDP (PGDP), population density (PD), environmental regulations (ER), energy consumption (EC), and industrial structure upgrading (ISU) on CO2 emissions (CO2e). For this purpose, a sample dataset covering the 30 provincial regions in mainland China from 2005 to 2019 was analyzed using the Fixed Effects and System Generalized Method of Moment (SYS-GMM) Methodology. The empirical results showed that CO2e in the current period were further aggravated due to the agglomeration effect of CO2e from the previous period. The data analysis indicated that GI, ER, and ISU all exert a significant inhibitory effect on CO2e, whereas PGDP, PD, and EC had a positive effect on carbon emissions when dynamic relationships were analyzed. In the regional heterogeneity test, the current model also revealed that the impact of GI on diminishing CO2e was more pronounced in the east-central region, but not in the west. It is suggested that policymakers in China not only design differentiated policies in response to regional heterogeneity, but also focus on the decisive role of green technology application, environmental protection, and green transformation of industrial structure in curbing CO2e.
Modeling and analysis of magnetically coupled piezoelectric dual-beam with an annular potential energy function for broadband vibration energy harvesting
Authors: Shao Nan , Chen Zhuo Master , Wang Xian , Zhang Chengxin , Xu Jiawen , Xu Xiaosu , Yan Ruqiang 
Published: January 2023

Abstract
Conventional piezoelectric cantilever-based vibration energy harvesters have narrow bandwidth. In this article, we develop a dual-beam piezoelectric energy harvester featuring an annular potential energy function that can harvest vibration energy over a wide spectrum under small amplitude excitations. The proposed harvester contains two conventional piezoelectric cantilevers placed orthogonal to each other which are coupled by repulsive magnetic force. We demonstrate analytically and numerically that a new annular potential energy function can be configurated with proper configuration. In the new annular stable state, the harvester can detour around the potential barrier rather than jump over it, yielding large-amplitude voltage outputs throughout a wide spectrum. Case studies were carried out and it is proved that the proposed annular stable harvester has a bandwidth of 3.9 Hz and a voltage output performance 3.01 times better than that of a conventional bistable one under excitations of 3 m/s2. The nonlinear dynamics of the proposed harvester are analyzed in detail.
Complex Physical Therapy employing self-adjusting garment (Ready Wrap®) in breast cancer-related lymphedema cases in Brazilian women: A protocol for a randomized clinical trial
Authors: Silva Jéssica Malena Pedro da , Araújo Raul Denner Duarte , Santos Francisca Cristina da Silva , Fabro Erica Alves Nogueira , Pinto Marcus Vinicius de Mello , de Aguiar Suzana Sales , Thuler Luiz Claudio Santos , Bergmann Anke 
Published: January 2023

Abstract
Background

Lymphedema is a common complication following breast cancer treatment. The aim of this study is to evaluate the effectiveness of a self-adjusting compression garment (Ready Wrap®) in reducing (phase 1) and maintaining (phase 2) upper limb volume in women presenting breast cancer-related lymphedema.

Methods

This study will comprise a randomized, controlled, single-blind clinical trial concerning women with breast cancer-related lymphedema undergoing treatment at a public cancer treatment reference hospital in the city of Rio de Janeiro, Brazil. The intervention will be carried out by adapting self-dressing versus the standard treatment of compressive bandaging (phase 1), and compressive mesh (phase 2). Both groups will be assessed at the beginning and end of intensive treatment and followed up for up to 12 months to evaluate immediate and late outcomes. Assessments will be carried out by physical upper limb examination (inspection, palpation, volume, dynamometry, and thermography), and a questionnaire application to assess patient quality of life concerning affected upper limb health, functionality and symptoms, adverse effects, adherence and treatment of the. Data will be analyzed descriptively and analytically through univariate and multiple linear regressions. P values < 0.05 will be considered statistically significant.

Discussion

This study will evaluate the effectiveness of a self-adjustable garment (Ready Wrap®) in the treatment of lymphedema secondary to breast cancer in Brazilian women compared to the gold standard treatment for limb volume reduction (phase 1) and maintenance (phase 2) phases comprising, respectively, a compressive bandaging and a compressive mesh. The outcome results will provide data based on both quantitative responses and self-reported participant outcomes. The study will also assess the cost-effectiveness of the Ready Wrap® treatment versus standard care. Finally, we expect to reaffirm one more product/therapy as a treatment for this extremely complex and impactful condition following the data analysis.

Trial registration

NCT04934098 [Clinical trials phase 1] and NCT04881604 [Clinical trials phase 2]
FNH in a Child with Congenital Extrahepatic Portosystemic Shunt (Abernethy Malformation)：A Case Report
Authors: Wang Chi , Yan Yuchun , Yang Yang , Ma Shuai , Tao Ran 
Published: January 2023

Abstract
Background Abernethy malformation, namely congenital extrahepatic portosystemic shunt (CEPS) is a rare congenital anomaly of the splanchnic venous system. Abernethy malformation is often associated with liver tumors. FNH often appears in children with Abernethy Malformation.
Case Presentation we report a focal nodular hyperplasia (FNH) child which finally vanished after blocking the inferior mesenteric vein and restored portal blood flow. Conclusions FNH in children with Abernethy Malformation should not be actively resected. After blood flow reconstruction, FNH may disappear.
Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cells
Authors: Duan Yajian , Wu Wenyi , Cui Jing , Matsubara Joanne Aiko , Kazlauskas Andrius , Li Xiaorong , Lei Hetian 
Published: January 2023

Abstract
Background
Epiretinal membranes in patients with proliferative vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types including retinal pigment epithelial (RPE) cells and fibroblasts, whose contraction causes retinal detachment. In RPE cells depletion of platelet-derived growth factor (PDGF) receptor (PDGFR)β suppresses vitreous-induced Akt activation, whereas in fibroblasts Akt activation through indirect activation of PDGFRα by growth factors outside the PDGF family (non-PDGFs) plays an essential role in experimental PVR. Whether non-PDGFs in the vitreous, however, were also able to activate PDGFRβ in RPE cells remained elusive.
Methods
We showed that expression of a truncated PDGFRβ lacking a PDGF-binding domain in the RPE cells whose PDGFRB gene had been silent using the CRISPR/Cas9 technology restored vitreous-induced Akt activation as well as cell proliferation, epithelial-mesenchymal transition, migration and contraction.
Results
We found that scavenging reactive oxygen species (ROS) with N-acetyl-cysteine and inhibiting Src family kinases (SFKs) with their specific inhibitor SU6656 blunted the vitreous-induced activation of the truncated PDGFRβ and Akt as well as the cellular events related to the PVR pathogenesis.
Conclusions
These discoveries suggest that in RPE cells PDGFRβ can be activated indirectly by non-PDGFs in the vitreous via an intracellular pathway of ROS/SFKs to facilitate the development of PVR, thereby providing novel opportunities for PVR therapeutics.
Genetic detection of two novel LRP5 mutations in patients with familial exudative vitreoretinopathy
Authors: Li Jia-yu , Wang Chan-juan , Zhang Shao-chi , Cai Bo , Pan Bo , Sun Cai-hong , Qi Xiao-long , Ma Chun-mei , Fang Wei , Jin Kang-xin , Bi Xiao-jun , Jin Zi-Bing , Zhuang Wen-juan 
Published: January 2023

Abstract
Objective
To identify causative genetic mutations by targeted exome sequencing in 9 independent pedigrees with familial exudative vitreoretinopathy (FEVR) and characterize the novel pathogenic mutations by molecular dynamics simulation.
Methods
Clinical data were collected from 9 families with FEVR. The causative genes were screened by targeted next-generation sequencing (TGS) and verified by the Sanger sequencing. In silico analyses (SIFT, Polyphen2, Revel, Mutation taster, and GERP++) were carried out to evaluate the pathogenicity of the mutations. Molecular dynamics was simulated to predict the alterations of protein conformation and flexibility transformation on pathogenesis.
Results
A 44% overall detection rate was achieved with four mutations including c.4289delC:p.Pro1431Argfs*8, c.2073G > T:p.Trp691Cys, c.1801G > A:p.Gly601Arg in LRP5 and c.633T > A:p.Tyr211* in TSPAN12 in 4 unrelated probands. Based on in silico analysis and ACMG standard, two of them, c.4289delC:p.Pro1431Argfs*8 and c.2073G > T:p.Trp691Cys of LRP5 were identified as novel pathogenic mutations. According to a molecular dynamics simulation, both mutations altered the secondary structure and spatial conformation, thus compromising its stability and flexibility.
Conclusion
Two novel genetic variants of the LRP5 gene were found to contribute to FEVR in this study, enriching the mutation spectrum of this condition. The impact of these two mutations on protein structure was validated by molecular dynamics simulation, further evidencing their pathogenicity.
Heterogeneous Decentralized Machine Unlearning with Seed Model Distillation
Authors: Ye Guanhua , Chen Tong , Nguyen Quoc Viet Hung , Huang Zi , Zhou Xiaofang , Yin Hongzhi 
Published: January 2023

Abstract
As some recent information security legislation endowed users with unconditional rights to be forgotten by any trained machine learning model, personalized service providers must put unlearning functionality into their consideration. The most straightforward method to unlearn users’ contribution is to retrain the model from the initial state, which is not realistic in high throughput applications with frequent unlearning requests. Though some machine unlearning frameworks have been proposed to speed up the retraining process, they fail to match decentralized learning scenarios. In this paper, we design a decentralized unlearning framework called HDUS, which uses distilled seed models to construct erasable ensembles in all clients. Moreover, the framework is compatible with heterogeneous on-device models, representing stronger scalability in real-world applications. Extensive experiments on three real-world datasets show that our HDUS achieves state-of-the-art performance.
Knowledge, perception and practice of antibiotic use among livestock farmers in the Central Division of Fiji
Authors: Shah Shameel , Charan Harshna , Carlisle Karen , MacLaren David , Palagyi Anna 
Published: January 2023

Abstract
This mixed-methods study aimed to: 1) characterise veterinary antimicrobial imports into Fiji over a 12 month period; and 2) evaluate the knowledge, perception and practice of antibiotic use and antimicrobial resistance (AMR) among livestock farmers in the Central Division of Fiji. Out of 15 antibiotic import shipments during November 2016−October 2017, just under half (40%) were initiated by non-government veterinarians, with the broad-spectrum antibiotics amoxicillin and cephalosporin being imported most frequently. 7% of antibiotic imports were initiated by individual (non-veterinary) users. Semi-structured interviews with 10 livestock farmers from Fiji’s Central Division found that, despite the widespread use of antibiotics with livestock, farmers were not aware of AMR or its risk to public and animal health. Educational barriers and social norms may discourage farmers from questioning veterinary personnel about antibiotic administering practices. Veterinarian-delivered education and awareness campaigns may be considered to help improve veterinary−farmer AMR communications and assist Fijian livestock farmers to optimise antibiotic usage.
Audiovisual resource in patients in the preoperative period of myocardial revascularization: a randomized clinical trial
Authors: de Araújo Naryllenne Maciel , Silva Silmara de Oliveira , Silva Louise Constancia de Melo Alves , Mendes Francisco de Cássio de Oliveira , Sarmento Sabrina Daiane Gurgel , Ribeiro Kátia Regina Barros , Dantas Rodrigo Assis Neves , Dantas Daniele Vieira 
Published: January 2023

Abstract
Cardiac surgery involves increased anxiety associated with lack of knowledge about the procedure. Thus, health education can be beneficial as a technological tool in the preoperative period for self-care and control of patient anxiety. The objective was to evaluate the effect of the audiovisual resource in the acquisition of knowledge about the level of anxiety in the preoperative period of myocardial revascularization. Randomized clinical trial with 44 patients in the preoperative period of coronary artery bypass grafting, equally divided into two groups. The control group (CG N = 22) received only verbal instructions and the experimental group (EG N = 22) received intervention from an audiovisual resource. Data were collected through a knowledge questionnaire and the State-Trait Anxiety Inventory. The analysis was performed using Student's t, chi-square and Fisher's exact tests. There was a statistically significant difference in favor of the group that received the intervention with the audiovisual resource, in addition to an increase in positive feelings after preoperative guidance. The effectiveness of the video in nursing guidance in the preoperative period of cardiac surgery was verified, facilitating the surgical process for the patient and offering a tool for the nurses' work process for an evidence-based practice. Trial registration: the Brazilian Clinical Trials Registry (REBEC) platform under number RBR-24c5qwm (27/05/2021).
Fallopian tube abscess caused by Escherichia coli in a 12-year-old adolescent virgin: a case report and review of the literature
Authors: He Xi-Feng , Du Xiu-Ping , Qiao Cui-Feng 
Published: January 2023

Abstract
Background: Fallopian tube abscess in adolescent virgins is very rare，it may lead to long-term or even lifelong complications once it occurred.
Case: A 12-year-old adolescent virgin with no history of sexual intercourse and previous physical fitness who presented with lower abdominal pain with nausea and vomiting for 22 hours. Laparoscopic surgery revealed an abscess in the left fallopian tube，the left fallopian tube was surgically removed and the pus was cultured for E. coli.
Summary and Conclusion: It is important to consider pelvic abscess in the differential diagnosis of adolescent virgins with clinical symptoms of acute abdomen.E. coli may be the causative agent.
Presentation of severe brucellosis in 5-year-old boy - challenges and results
Authors: Dinikina Yulia , Tsoy Uliana , Dyachkov Andrey , Grozov Roman , Mushkin Aleksandr , Zorin Vyacheslav , Nikitina Irina , Grineva Elena 
Published: January 2023

Abstract
Brucellosis is highly contagious zoonotic bacterial disease caused by gram-negative genus. It has a wide spectrum of clinical manifestations and due to variety and nonspecificity of clinical signs the diagnostics can be very complicated. We present a clinical case of severe chronic brucellosis in a 5-years old boy with long-term course of disease and multiorgan involvement. A different complication of brucellosis including severe syndrome of inappropriate ADH secretion (SIADH) are discussed. Despite severe course of disease patient achieved significant clinical improvement due to multidisciplinary approach and optimal etiotropic and pathogenetic treatment.