bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activity-Dependent Nr4a2 Induction Modulates Synaptic Expression of AMPA Receptors and Plasticity via a Ca2+/CRTC1/CREB Pathway
Authors: Català-Solsona Judit , Lituma Pablo J. , Lutzu Stefano , Siedlecki-Wullich Dolores , Fábregas-Ordoñez Cristina , Miñano-Molina Alfredo J. , Saura Carlos A. , Castillo Pablo E. , Rodriguez-Álvarez José 
Published: March 2023

Transcription factors have a pivotal role in synaptic plasticity and the associated modification of neuronal networks required for memory formation and consolidation. The nuclear receptors subfamily 4 group A (Nr4a) have emerged as possible modulators of hippocampal synaptic plasticity and cognitive functions. However, the molecular and cellular mechanisms underlying Nr4a2-mediated hippocampal synaptic plasticity are not completely known. Here, we report that neuronal activity enhances Nr4a2 expression and function in cultured mouse hippocampal neurons (both sexes) by an ionotropic glutamate receptor/Ca2+/cAMP response element-binding protein/CREB-regulated transcription factor 1 (iGluR/Ca2+/CREB/CRTC1) pathway. Nr4a2 activation mediates BDNF production and increases expression of iGluRs, thereby affecting LTD at CA3-CA1 synapses in acute mouse hippocampal slices (both sexes). Together, our results indicate that the iGluR/Ca2+/CREB/CRTC1 pathway mediates activity-dependent expression of Nr4a2, which is involved in glutamatergic synaptic plasticity by increasing BDNF and synaptic GluA1-AMPARs. Therefore, Nr4a2 activation could be a therapeutic approach for brain disorders associated with dysregulated synaptic plasticity.SIGNIFICANCE STATEMENTA major factor that regulates fast excitatory synaptic transmission and plasticity is the modulation of synaptic AMPARs. However, despite decades of research, the underlying mechanisms of this modulation remain poorly understood. Our study identified a molecular pathway that links neuronal activity with AMPAR modulation and hippocampal synaptic plasticity through the activation of Nr4a2, a member of the nuclear receptor subfamily 4. Since several compounds have been described to activate Nr4a2, our study not only provides mechanistic insights into the molecular pathways related to hippocampal synaptic plasticity and learning, but also identifies Nr4a2 as a potential therapeutic target for pathologic conditions associated with dysregulation of glutamatergic synaptic function.
When Response Selection Becomes Gambling: Post-error Slowing and Speeding in Self-paced Colour Discrimination Tasks
Authors: Eben Charlotte , Vermeylen Luc , Chen Zhang , Notebaert Wim , Ivanchei Ivan , Verbruggen Frederick 
Published: March 2023

People tend to slow down after committing an error in many tasks. However, some studies failed to observe such post-error slowing. Furthermore, recent work found speeding after another type of sub-optimal outcomes: people often speed up after losses in gambling situations. What features determine whether people slow down or speed up after sub-optimal outcomes (error vs. loss)? To answer this question, we focused on the role of task characteristics and control over the outcome, by making a task where we previously observed post-error slowing more like tasks where we previously observed post-loss speeding. First, we made a color-discrimination task completely self-paced (Experiment 1A) and added reward/punishment (Experiment 1B). In both experiments, post-error slowing was observed, without modulation by reward/punishment. We then manipulated task difficulty to investigate the influence of control over the outcome. Consistent with our predictions, control over the outcome modulated post-error adjustments, as participants slowed down after controllable errors, but sped up after uncontrollable errors (Experiment 3). Importantly, this effect was global as post-error speeding was observed when controllable and ’uncontrollable’ errors were intermixed (Experiment 2), suggesting an influence of overall task context. Thus, responses to sub-optimal outcomes might depend on the control over the outcome.
Mitochondrial‐derived vesicles retain membrane potential and contain a functional ATP synthase
Authors: Hazan (Ben‐Menachem) Reut , Lintzer Dvora , Ziv Tamar , Das Koyeli , Rosenhek‐Goldian Irit , Porat Ziv , Ben Ami Pilo Hila , Karniely Sharon , Saada Ann , Regev‐Rudzki Neta , Pines Ophry 
Published: March 2023

AbstractVesicular transport is a means of communication. While cells can communicate with each other via secretion of extracellular vesicles, less is known regarding organelle‐to organelle communication, particularly in the case of mitochondria. Mitochondria are responsible for the production of energy and for essential metabolic pathways in the cell, as well as fundamental processes such as apoptosis and aging. Here, we show that functional mitochondria isolated from Saccharomyces cerevisiae release vesicles, independent of the fission machinery. We isolate these mitochondrial‐derived vesicles (MDVs) and find that they are relatively uniform in size, of about 100 nm, and carry selective protein cargo enriched for ATP synthase subunits. Remarkably, we further find that these MDVs harbor a functional ATP synthase complex. We demonstrate that these vesicles have a membrane potential, produce ATP, and seem to fuse with naive mitochondria. Our findings reveal a possible delivery mechanism of ATP‐producing vesicles, which can potentially regenerate ATP‐deficient mitochondria and may participate in organelle‐to‐organelle communication.
Як стати ученим? (до 75-річчя доктора історичних наук, професора Геннадія Кривчика)
Authors: Іваненко Валентин 
Published: March 2023

У статті з’ясовано й висвітлено основні віхи і окремі фрагменти життєвої та професійної біографії професора Г. Кривчика як представника дніпропетровської історичної школи і одного з відомих дослідників у галузі аграрної історії України новітнього часу. Методи дослідження: історико-хронологічний, історико-біографічний, логічний. Джерела: опубліковані й неопубліковані матеріали епістолярного і мемуарного характеру вченого, його найважливіші наукові, публіцистичні та навчальні праці, деякі публікації, а також особисті згадки і спостереження автора про нього.
Основні результати. Встановлено і стисло описано найбільш примітні біографічні дати, події, факти з розмаїття життєвих картин Г. Кривчика від народження до сьогодення, показано родинні впливи на його виховання як особистості; розкрито витоки його становлення як науковця і педагога у Дніпропетровському державному університеті, простежено динаміку кар’єрного зростання на посадах завідувача кафедри у Дніпропетровському інженерно-будівельному інституті (нині – Придніпровська академія будівництва та архітектури) і Дніпропетровському національному університеті залізничного транспорту ім. академіка В. Лазаряна (нині – Український державний університет науки і технологій), які стали потужним осердям і органічною частиною його професійного життя упродовж кількох десятиліть. Зроблена спроба виявити й позначити певні мотиваційні чинники вибору ним стратегії наукових пошуків, спочатку переважно у площині соціального функціонування українського села у 1960-1980-х рр., а останнім часом – в руслі осмислення актуальних проблем етнополітичної історії України, зокрема, історичних передумов і генези формування української національної ідеї, сучасного розвитку національних відносин в країні, методології історії, філософії, політології, педагогіки вищої школи, державного управління тощо. З’ясовано загальний творчий доробок ученого у вигляді опублікованих праць, захищених дисертацій, підготовлених ним кадрів вищої кваліфікації.
Висновки. Професор Г. Кривчик, розпочавши кар’єрне сходження у часи компартійного всевладдя, з відповідних світоглядних й ціннісних орієнтацій, потім пройшов досить тернистий шлях професійного самовдосконалення й теоретико-методологічного самоочищення, завдяки чому зміг створити співзвучні нашому сьогоденню інтелектуальні продукти й залишити помітний слід у фаховому середовищі Придніпров’я та України. Практичне значення. Матеріал статті може бути використаний у відповідних наукових проєктах з української історії другої половини XX – початку XXI ст., в освітньому процесі з підготовки істориків в університетах. Наукова новизна. Вперше актуалізовано й розкрито деякі найбільш виразні штрихи до інтелектуального портрета самобутнього історика. Тип статті: описова.
English for Food Production Technologists. English for Food Industry Technologists
Authors:   Novosibirsk State Technical University, Russian Federation, Smakotina Natalia A. , Teleguz Anna A. ,   Novosibirsk State Technical University, Russian Federation, Tolstobrova Lyudmila I. ,   Novosibirsk State Technical University, Russian Federation, Gordienko Marina V. ,   Novosibirsk State Technical University, Russian Federation
Published: March 2023

The textbook "English for Food Production Technologists" English for food technologists is intended for second-year students specializing in the field of training "Product technology and catering organization (19.03.04 ): Profile: Technology and Organization of Restaurant Service", "Management: Profile: Management in the food industry" (38.03.02).	The purpose of the textbook is to form a foreign language communicative competence based on a given situational professionally – oriented context. The structure of the textbook. The textbook consists of four modules with three sections, blocks of control and measurement and additional materials, and a grammar reference. The content of the modules: Module 1. Fundamentals of Nutrition Science; Module 2. Food Industry; Module 3. Introduction to Food Engineering; Module 4. Food of the Future. Each section of the textbook modules contains specialized text materials devoted to the basics of nutrition science, food processing, automation of food processing and production processes, and focused on the development of language, speech and communication skills. The study of the specialized material is completed by performing tasks of a creative nature in oral or written form. The textbook materials are intended for classroom activity, distance learning, as well as for independent work of students.
Evaluating Spatiotemporal Trends in Infrasound Propagation Using Seismoacoustic Arrivals from Repeating Explosions
Authors: Wynn Nora , Dannemann Dugick Fransiska , Carmichael Joshua D. , Thiel Andrew D. 
Published: March 2023

ABSTRACT
Recent studies have demonstrated the utility of seismic stations for recording acoustic signals from events of interest. Here, we present an analysis of seismoacoustic arrivals originating from weekly controlled munition disposals at the McAlester Army Ammunition Plant (McAAP) in Oklahoma over a period of nine months during 2019. These arrivals were recorded on 121 temporary and permanent seismic stations across Oklahoma and surrounding states. Arrivals were identified by a human analyst team. Because of its consistency and duration, the McAAP dataset provides an opportunity to study the spatial and temporal variability of infrasound propagation because it relates to seasonally variable atmospheric conditions. Recorded arrivals identify an acoustic shadow zone ranging in distance from 50 to 200 km of the source, along with seasonal directional shifts in the stratospheric duct. Acoustic raytracing is used to produce comparisons of predicted and observed arrival dynamics, concluding that current atmospheric specifications do not capture the full complexity of the atmosphere.
The 2022 Delingha, China, Earthquake Sequence and Implication for Seismic Hazard near the Western End of the Qilian–Haiyuan Fault
Authors: Li Wei , He Xiaohui , Zhang Yipeng , Wang Yue , Liu Bin , Ni Sidao , Zhang Peizhen 
Published: March 2023

AbstractAlthough the Qilian–Haiyuan fault is known to be responsible for major earthquakes up to M 8, the potential of damaging earthquakes near its western end is not well understood. Since January 2022, three moderate earthquakes (M 5.8, M 6.0, and M 5.4) occurred around the Halahu region of Delingha, China, near the western end of the Qilian–Haiyuan fault. These earthquakes are unusual M 5+ events in this low-seismicity region, and both the U.S. Geological Survey and Global Centroid Moment Tensor solutions suggest that the focal mechanisms of the three mainshocks are distinct from the activity characteristics of the nearby mapped faults. Thus, determining the precise source parameters and identifying the causative fault of this earthquake sequence are important to analyze its seismogenic settings and seismic hazard in this region. In this article, we determined the point-source parameters of the three moderate events via regional waveform modeling and found that these earthquakes are strike-slip events with the nodal planes striking nearly north–south and east–west directions. We then resolved its seismogenic faults by analyzing the aftershock distribution and the rupture directivity. The results show that both the M 5.8 and M 6.0 events ruptured along the north–south nodal plane and expanded toward the south for ∼4 km and ∼3 km, respectively, and the ruptured fault of the M 5.4 is difficult to distinguish. Furthermore, we constrained the relative location using the Interferometric Synthetic Aperture Radar observation, and the result is consistent with that obtained from seismic waveform data. We proposed that this earthquake sequence ruptured along an unmapped dextral fault, which forms a conjugate fault system with the sinistral strike-slip Qilian–Haiyuan fault. Its deformation mechanism may be controlled by long-term, protracted, nearly north–south-trending, right-lateral simple shear in the Qilian Shan fold-thrust belt. The accumulated static Coulomb stress changes resulted in the northwest of this ruptured fault being closer to failure in the future.
Hypocenter, Fault Plane, and Rupture Characterization of Australian Earthquakes: Application to the September 2021 Mw 5.9 Woods Point Earthquake
Authors: Mousavi Sima , Hejrani Babak , Miller Meghan S. , Salmon Michelle 
Published: March 2023

AbstractThe Australian Seismometers in Schools (AuSIS) network operates 50 broadband seismic stations across Australia that are hosted at schools. The instruments augment the Australian National Seismograph Network providing valuable data from urban and regional Australia. The network coverage is quite sparse, but these vital records of rare, moderate Australian earthquakes can improve our understanding of the deformation within the stable continental region of Australia, especially for events with no surface rupture. In this study, we present the feasibility of identifying the fault plane of moderate earthquakes on the Australian continent, using data from the AuSIS network. We examine the fault plane of the September 2021 Mw 5.9 Woods Point earthquake that occurred about 130 km northeast of the Melbourne metropolitan area. We estimate the hypocenter and the centroid moment tensor (CMT) to identify the fault plane from the auxiliary plane in the focal mechanism. We explore a range of 1D models and a 3D Earth model to simulate seismic arrivals and full waveform data. The hypocenter is resolved using P- and S-wave arrivals in a probabilistic framework and the CMT is derived from full waveform modeling through grid search over a set of trial points around the hypocenter. Our solution suggests the mainshock ruptured the depth of 15 ± 4 km, with a strike-slip mechanism striking 348° north on a nearly vertical plane. The high double-couple percentage of this event indicates a simple rupture that propagated from the south (hypocenter) toward the north (centroid) and remained subsurface. This indicates that the causative fault had a deeper structure than the previously known shallow, northwest–southeast-striking faults of the region. The P and T axes deduced from our fault model are notably aligned with the maximum horizontal crustal stress in the region.
Anomalous Crustal Stress in the Eastern Tennessee Seismic Zone
Authors: Levandowski Will , Powell Christine , Chapman Martin , Wu Qimin 
Published: March 2023

AbstractThe eastern Tennessee seismic zone (ETSZ) experiences the second highest rates of natural seismicity in the central and eastern United States (CEUS), following the New Madrid area, yet the cause of elevated earthquake rates is unknown. We probe the origin of ETSZ seismicity using geomechanically constrained stress inversions of earthquake focal mechanisms from 57 earthquakes, including 24 newly derived here and five from the recent events not used in the previous stress studies. Highly oblique northwest–southeast (NW–SE) extension that is unique in the CEUS dominates the ETSZ—central Alabama to southeastern Kentucky—and preferentially reactivates normal to strike-slip faults in the northeast (NE) and southwest (SW) quadrants (strikes 018°–086° or 196°–272° and dips 55°–90°). This extension cannot be explained by the compressive tectonic plate-boundary tractions that cause oblique NE–SW contraction elsewhere in the CEUS. Although our analyses do not uniquely determine the origin of the anomalous stress, we favor isostatic disequilibrium, due to anything from surface processes to crust–mantle interactions, as the possible cause. Increased long-term seismic hazard in the ETSZ may be controlled by and confined to the spatial extent of this anomalous seismotectonic state.
Védett törpecsigafajok (Vertigo angustior és V. moulinsiana), egy faunára új kagyló (Pisidium pulchellum) és más puhatestűek előfordulása a szőcei tőzegmohás láprétek területén
Authors: Herényi Márton , Majoros Gábor , Csonka Anna Cseperke , Fehér Zoltán 
Published: March 2023

Az Őrségi Nemzeti Park keleti szélén elterülő szőcei tőzegmohás láprétek számos ritka növény- és állatfajnak adnak otthont. Bár már számtalan, különböző témájú publikáció jelent meg a területről, a puhatestű-faunával kapcsolatban eddig egyetlen közlemény sem látott napvilágot. Vizsgálatunk célja egyrészt a réteken és környezetükben élő puhatestűfajok jobb megismerése volt, másrészt arra a kérdésre kerestük a választ, előfordulnak-e itt a védett, közösségi jelentőségű törpecsigafajaink (Vertigo angustior és Vertigo moulinsiana), valamint hogy ezek mely területeken és milyen élőhelyi viszonyok mellett találhatók meg. A 2020. és 2022. közötti gyűjtések során 33 puhatestűfajt mutattunk ki a területről, amelyek közül 16 fajnak még nem volt adata Szőcéről. Különösen érdekes a Pisidium pulchellum kagylófaj előkerülése, amelynek ez az első bizonyítottan recens magyarországi előfordulása. Mindkét védett törpecsigát több mintavételi ponton is megtaláltuk. Előfordultak különböző nedvességű, kitettségű, illetve különböző gyakorisággal kaszált részeken is. Egyedsűrűségük más hazai előfordulási helyeikkel összevetve nem mondható alacsonynak, amely ellentmond annak a tapasztalatnak, miszerint e fajok mészben szegény, savanyú talajú élőhelyeken nem, vagy csak kis számban lelhetők fel. A réteken alkalmazott különböző intenzitású kaszálás látszólag nem befolyásolja a Vertigo-fajok előfordulását, de ahol nagyobb egyedszámban vannak jelen, ott az igényeiket előtérbe helyező, a növényborítást meghagyó kezelés lehet indokolt.
Hubungan Tingkat Pendidikan dan Pekerjaan dengan Kejadian Covid-19 di Puskemas Pemurus Dalam Kota Banjarmasin
Authors: Rahman Fajar Satria , Heriyani Farida , Nurrasyidah Ira , Noor Meitria Syahdatina , Washilah Siti 
Published: March 2023

Abstract: The incidence of COVID-19 continues to increase, especially in the city of Banjarmasin. The increasing number of cases of COVID-19 is caused by several factors, including sociodemographic risk factors such as level of education and occupation. This study aims to analyze the relationship between education and employment levels with the incidence of COVID-19 at the Pemurus Dalam Health Center in Banjarmasin City. The research method is analytic observational with a case control approach. Sampling using simple random sampling technique with a total sample of 64 patients Pemurus Dalam City Health Center Banjarmasin who have met the inclusion and exclusion criteria, then analyzed using the chi-square test. The results showed that there was a relationship between education level and the incidence of COVID-19 which had a p value of 0.026, and the relationship between work and the incidence of COVID-19 which had a p value of 0.035. The two results show that there is a significant relationship (p value < 0.05) between education and occupation levels with the incidence of COVID-19. Keywords: Incidence, Education, Occupation, COVID-19 Abstrak: Kejadian COVID-19 hingga saat ini terus meningkat terutama di Kota Banjarmasin. Meningkatanya kasus kejadian COVID-19 disebabkan oleh beberapa faktor, antara lain faktor risiko sosiodemografik seperti tingkat pendidikan dan pekerjaan. Penelitian ini bertujuan untuk menganalisis hubungan tingkat pendidikan dan pekerjaan dengan kejadian COVID-19 di Puskesmas Pemurus Dalam Kota Banjarmasin. Metode penelitian adalah observasional analitik dengan pendekatan case control. Pengambilan sampel menggunakan teknik simple random sampling dengan jumlah sampel sebanyak 64 pasien Puskesmas Pemurus Dalam Kota Banjarmasin yang telah memenuhi kriteria inklusi dan eksklusi, selanjutnya dianalisis menggunakan uji chisquare. Hasil penelitian menunjukan terdapat hubungan antara tingkat pendidikan dengan kejadian COVID-19 yang memiliki p value sebesar 0,026, dan hubungan antara pekerjaan dengan kejadian COVID-19 yang memiliki p value sebesar 0,035. Kedua hasil tersebut menunjukkan bahwa terdapat hubungan yang bermakna (p value < 0,05) antara tingkat pendidikan dan pekerjaan dengan kejadian COVID-19. Kata-kata kunci: kejadian, tingkat pendidikan, pekerjaan, COVID-19