bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efektifitas Terapi Akupuntur Terhadap Penderita Hipertensi
Authors: Wijayanti Agnes Erida , Setiyawan Doni , Widyaningtyas Regina 
Published: July 2023

Background of Study : Hypertension in elderly caused by many factors that were closely related with aging process. One of the non-pharmacological treatment methods is acupuncture therapy. The needle prick method in acupuncture will stimulate the release and activation of active substances such as Nitric Oxide (NO). Needle prick at the acupuncture will stimulate impulses parasympathetic nervous and pressed sympathetic nervous. The parasympathetic dominant will issue of acetylcholine, Where ties acetylcholine in endothelial cells to induce the formation of local nitrite oxide, Which are then diffuses passing through the smooth muscle blood vessels, and then affect blood flow and local, circulation so there. smooth muscle relaxation of the blood vessels. Research purposes determine the effect of acupuncture on hypertensive patients.Methods : This research was conducted in Klinik pakualaman II Omah Gandok Tajem Sleman. This research is a pre-experimental research design with One-Group Pretest-Posttest Design. The population in this study were patients with hypertension and the sample was taken by purposive sampling method. The data were processed and analyzed using paired t-test with a significance value of p0.05.Results : The results obtained that the value of p = 0.000 in the systole measurement and p = 0.007 in the diastolic measurement (p 0.05) means that there is a significant difference in the respondent's blood pressure before acupuncture is performed with blood pressure after acupuncture is performed.Conclusion : there is a difference in the decrease in blood pressure before and after being given acupuncture therapy
PENGARUH PERTUMBUHAN PENDUDUK, KESEMPATAN KERJA, DAN INVESTASI TERHADAP TINGKAT PENGANGGURAN DI KOTA PEKANBARU
Authors: Agnesia Dini , Ekwarso Hendro , Utami Bunga Chintia 
Published: July 2023

This study aims to determine the effect of population growth, Employment opportunities, and investment on the unemployment rate in Pekanbaru City. The data used is time series data for the period 2006-2021. The research uses multiple linear regression analysis method using SPSS version 25 statistical program. The results showed that partially population growth had a negative and significant effect on the unemployment rate, employment opportunities had a negative and significant effect on the unemployment rate, and invesmant had a negative and significant effect on the unemployment rate in Pekanbaru City. Simultaneously population growth, employment opportunities and investment have a significant effect on the unemployment in Pekanbaru City. The value of Adjusted R-Squared in this study is 0,909, which means that 90,9% of the labor absorption variable can be explained by the independent variables in this study, the remaining 9,1% is explained by other variables outside the research model.
Paragraph-oriented methods for determining the coherence and thematic unity of scientific and technical texts
Authors: Shevchenko Ihor , Andreev Pavlo , Dernova Maiia , Poddubei Olena 
Published: July 2023

The subject of the article is to determine the degree of scientific and technical text connectedness using statistical calculations. The aim of the scientific investigation is to study the possibilities of using the coherence of fluctuations in the relative frequencies of keywords in paragraphs to determine the lexical coherence and thematic unity of scientific and technical texts. The task is to develop a method for determining the thematic unity of a text at the set of paragraphs level; to develop a method for determining the coherence of a text at the set of paragraphs level; and to test the developed methods on a collection of documents. The methods used are statistical analysis and computational experiment methods. The following results were obtained. The study has shown that it is advisable to cluster paragraphs as points in the keyword space to determine the degree of scientific and technical text coherence at the level of paragraphs. This opens up the possibility of calculating the degree of thematic unity within the clusters and in the entire text. The degree of text fragments and the whole text coherence is determined by analyzing the sequence of paragraph numbers in the clusters. This makes it possible to formally determine the quality of the material presented in a scientific and technical article or in a textbook. Conclusions. The scientific novelty of the study is as follows: there was refined on the method for determination of the connectedness degree (coherence and thematic unity) of scientific and technical texts at the level of paragraphs by implementation of paragraphs clustering in the keywords space, using the calculation of thematic unity degree inside the clusters and in the overall text, as well as through analysis of paragraphs numbers sequence in clusters in order to determine the degree of text fragments and the overall text coherence. The methods are language-independent, based on clear hypotheses, and complement each other. The methods have an adjusting element that can be used to adapt it to different thematic and stylistic areas. It has been experimentally proved that the proposed methods for the determination of scientific and technical text connectedness are efficient and can provide the framework for information technology of content analysis of scientific and technical texts. The proposed methods do not use WEB resources for syntactic and semantic analysis, providing the possibility to use them autonomously.
Face recognition-based attendance system with anti-spoofing, system alert, and email automation
Authors: Hosen Md. Apu , Moz Shahadat Hoshen , Khalid Md. Mahamudul Hasan , Kabir Sk. Shalauddin , Galib Dr. Syed Md. 
Published: July 2023

The subject matter of the article is the design of an attendance system based on face recognition with anti-spoofing, system alarm, and Email Automation to improve accuracy and efficiency, highlighting its potential to revolutionize traditional attendance tracking methods. The administration of attendance might be a tremendous load on the authority if it is done manually. Therefore, the goal of this study is to design a reliable and efficient attendance system that can replace traditional manual approaches while also detecting and preventing spoofing attempts. Without the manual approach, attendance may be collected using many kinds of technologies, including biometric systems, radiofrequency card systems, and facial recognition systems. The face recognition attendance system stands out among the rest as a great alternative to the traditional attendance system used in offices and classrooms. The tasks to be accomplished include selecting appropriate facial detection and recognition technologies, implementing anti-spoofing measures to prevent intruders from exploiting the system, and integrating system alarms and email automation to improve accuracy and efficiency. The methods used include selecting the Haar cascade for facial detection and the LBPH algorithm for facial recognition, using DoG filtering with Haar for anti-spoofing, and implementing a speech system alarm for detecting intruders. The result of the system is a face recognition rate of 87 % and a false positive rate of 15 %. However, since the recognition rate is not 100 %, attendance will also be informed through email automation in case someone is present but is not detected by the system. In conclusion, the designed attendance system offers an effective and efficient alternative to the traditional attendance system used in offices and classrooms, providing accurate attendance records while also preventing spoofing attempts and notifying authorities of any intruders.
ASSESSING THE SUITABILITY OF THE LEE-CARTER MODEL IN MODELLING MORTALITY DATA WITH VARYING bx PARAMETER
Authors: Shelleng A. U. , Dikko H. G. , Garba J. , Alhaji B. B. 
Published: July 2023

The Lee-Carter model, developed by Lee and Carter in 1992 is one of the most influential model among others that is used for mortality projection. Although the model's performance has so far been examined in a variety of situations, its effectiveness in modeling mortality data with varying speeds of change in mortality across ages and the ability to detect trends in mortality index more precisely over time has not been studied. The method traditionally used in the Lee-Carter model shows obvious drawbacks in describing the shape of future mortality. The effectiveness of the Lee-Carter model to model mortality data with varying speeds of change in mortality was investigated. The model was applied to mortality data with both constant and varying speeds of change for female sub population. Results show that the Lee-Carter model is not good for mortality data with varying speeds of change.
Matarumah Parentah Oleh Saniri Negeri Rumahtiga Sebagai Tindakan Administrasi
Authors: Tita Heillen M.Y , Irham Muhammad , Mustamu Julista 
Published: July 2023

Ringkasan
Artikel ini bertujuan untuk menemukan perspektif hukum administrasi negara terkait penetapan Matarumah Parentah di Negeri Rumahtiga Kota Ambon. Seperti diketahui Saniri Negeri Rumahtiga sampai saat ini belum melanjutkan proses pembentukan Peraturan Negeri dalam rangka Penetapan Matarumah Parentah, padahal tahapan penetapan sudah dilalui sesuai dengan aturan yang berlaku. Melalui penelitian yuridis normatif didapatkan hasil bahwa sikap Saniri Negeri Rumahtiga merupakan tindakan administrasi pemerintah yang dapat diuji keabsahannya dan dapat dikategorikan sebagai sikap diam Pemerintah serta sebagai tindakan pemerintah berupa keputusan yang mencakup tindakan faktual sebagaimana dimaksud dalam Undang-Undang Administrasi Pemerintahan.
Kata Kunci: Penetapan, Matarumah Parentah, Hukum Administrasi Negara.
Daily behaviour and home range of adult rehabilitant Javan slow loris (Nycticebus javanicus É. Geoffroy, 1812) in Gunung Sawal Nature Reserve, Ciamis, West Java
Authors: Priatna Dolly , Hidayat Aris , Istiadi Yossa , Nurwati Ammy , Yanuar Ahmad , Susilo Adi 
Published: July 2023

This study aims to determine the differences in daily behaviour and home range of male and female rehabilitated Javan slow loris (Nycticebus javanicus) in Gunung Sawal Nature Reserve, Ciamis, West Java, Indonesia. The study was conducted on four individuals of Javan slow loris rehabilitates (two adult males and two adult females) during their post-released monitoring period. Those animals were fitted with a radio transmitter and were monitored for their daily behaviour and home range for six months (May - October 2018). The focal animal sampling method was employed for daily behaviour observation. The home range of each individual was estimated by Minimum Convex Polygon (MCP) and Kernel Density Estimation (KDE) methods. Data analysis was descriptively displayed in maps, tables, and figures. According to the statistical analyses of the Mann Whitney U test, there are no significant differences (μ = 1,074,554.5 [p 0.01]; P-Value 0.238 0.01) in the daily behaviour of male and female Javan slow loris rehabilitate. In contrast, the home range (vertically and horizontally) of female and male Javan slow loris rehabilitate are significantly different (μ = 816,286.0 [p 0.01]; P-Value 0.000 0.01). Penelitian ini bertujuan untuk mengetahui perbedaan perilaku harian dan wilayah jelajah kukang jawa (Nycticebus javanicus) jantan dan betina hasil rehabilitasi di Suaka Margasatwa Gunung Sawal, Ciamis, Jawa Barat, Indonesia. Penelitian dilakukan pada empat individu kukang jawa rehabilitan (dua jantan dewasa dan dua betina dewasa) selama masa pemantauan pasca pelepasliaran. Satwa-satwa tersebut dipasangi pemancar radio serta dipantau perilaku harian dan wilayah jelajahnya selama enam bulan (Mei - Oktober 2018). Metode pengambilan sampel "Focal Animal" digunakan untuk pengamatan perilaku harian. Daerah jelajah masing-masing individu diperkirakan dengan metode Minimum Convex Polygon (MCP) dan Kernel Density Estimation (KDE). Analisis data secara deskriptif ditampilkan dalam bentuk peta, tabel, dan gambar. Berdasarkan analisis statistik uji U-Mann Whitney, tidak terdapat perbedaan yang bermakna (μ = 1.074.554,5 [p 0,01]; P-Value 0,238 0,01) pada perilaku harian kukang jawa jantan dan betina yang direhabilitasi. Sebaliknya, wilayah jelajah (vertikal dan horizontal) kukang jawa betina dan jantan yang direhabilitasi berbeda nyata (μ = 816.286,0 [p 0,01]; P-Value 0,000 0,01).
Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations
Authors: Seys François M. , Humphreys Christopher M. , Tomi-Andrino Claudio , Li Qi , Millat Thomas , Yang Sheng , Minton Nigel P. 
Published: July 2023

Base editors are recent multiplex gene editing tools derived from the Cas9 nuclease of Streptomyces pyogenes. They can target and modify a single nucleotide in the genome without inducing double-strand breaks (DSB) of the DNA helix. As such, they hold great potential for the engineering of microbes that lack effective DSB repair pathways such as homologous recombination (HR) or non-homologous end-joining (NHEJ). However, few applications of base editors have been reported in prokaryotes to date, and their advantages and drawbacks have not been systematically reported. Here, we used the base editors Target-AID and Target-AID-NG to introduce nonsense mutations into four different coding sequences of the industrially relevant Gram-positive bacterium Clostridium autoethanogenum. While up to two loci could be edited simultaneously using a variety of multiplexing strategies, most colonies exhibited mixed genotypes and most available protospacers led to undesired mutations within the targeted editing window. Additionally, fifteen off-target mutations were detected by sequencing the genome of the resulting strain, among them seven single-nucleotide polymorphisms (SNP) in or near loci bearing some similarity with the targeted protospacers, one 15 nt duplication, and one 12 kb deletion which removed uracil DNA glycosylase (UDG), a key DNA repair enzyme thought to be an obstacle to base editing mutagenesis. A strategy to process prokaryotic single-guide RNA arrays by exploiting tRNA maturation mechanisms is also illustrated.
Acceptance of smart sensing: a barrier to implementation—results from a randomized controlled trial
Authors: Terhorst Yannik , Weilbacher Nadine , Suda Carolin , Simon Laura , Messner Eva-Maria , Sander Lasse Bosse , Baumeister Harald 
Published: July 2023

BackgroundAccurate and timely diagnostics are essential for effective mental healthcare. Given a resource- and time-limited mental healthcare system, novel digital and scalable diagnostic approaches such as smart sensing, which utilizes digital markers collected via sensors from digital devices, are explored. While the predictive accuracy of smart sensing is promising, its acceptance remains unclear. Based on the unified theory of acceptance and use of technology, the present study investigated (1) the effectiveness of an acceptance facilitating intervention (AFI), (2) the determinants of acceptance, and (3) the acceptance of adults toward smart sensing.MethodsThe participants (N = 202) were randomly assigned to a control group (CG) or intervention group (IG). The IG received a video AFI on smart sensing, and the CG a video on mindfulness. A reliable online questionnaire was used to assess acceptance, performance expectancy, effort expectancy, facilitating conditions, social influence, and trust. The self-reported interest in using and the installation of a smart sensing app were assessed as behavioral outcomes. The intervention effects were investigated in acceptance using t-tests for observed data and latent structural equation modeling (SEM) with full information maximum likelihood to handle missing data. The behavioral outcomes were analyzed with logistic regression. The determinants of acceptance were analyzed with SEM. The root mean square error of approximation (RMSEA) and standardized root mean square residual (SRMR) were used to evaluate the model fit.ResultsThe intervention did not affect the acceptance (p = 0.357), interest (OR = 0.75, 95% CI: 0.42–1.32, p = 0.314), or installation rate (OR = 0.29, 95% CI: 0.01–2.35, p = 0.294). The performance expectancy (γ = 0.45, p &lt; 0.001), trust (γ = 0.24, p = 0.002), and social influence (γ = 0.32, p = 0.008) were identified as the core determinants of acceptance explaining 68% of its variance. The SEM model fit was excellent (RMSEA = 0.06, SRMR = 0.05). The overall acceptance was M = 10.9 (SD = 3.73), with 35.41% of the participants showing a low, 47.92% a moderate, and 10.41% a high acceptance.DiscussionThe present AFI was not effective. The low to moderate acceptance of smart sensing poses a major barrier to its implementation. The performance expectancy, social influence, and trust should be targeted as the core factors of acceptance. Further studies are needed to identify effective ways to foster the acceptance of smart sensing and to develop successful implementation strategies.Clinical Trial Registrationidentifier 10.17605/OSF.IO/GJTPH.
Villagers’ attitudes and behaviors toward rural solid waste management under environmental authoritarianism in China
Authors: Li Hui , Huang Diejun , Li Hua , Ma Qiuzhuo , Li Juan 
Published: July 2023

Rapid urbanization and industrialization in China, combined with a rural-urban dual structure, have resulted in significant challenges for rural solid waste management (RSWM). Through the issuance of regulations and guidelines, and the allocation of substantial funds, the Chinese government has achieved remarkable success in implementing a top-down, linear, and authoritarian waste system, with the national village-level coverage rate of the rural waste management system growing from zero to over 90% in less than 20 years. This paper provides insights into the factors that influence villagers’ responses (attitudes and behaviors) to authoritarian environmental policy measures. Using primary data from Meizhou County in Guangdong Province (the poorest county in China’s richest province), the study finds that villagers’ attitudes are significantly affected by their satisfaction with the government’s RSWM and their environmental concern, while villagers’ behaviors are significantly influenced by their approval level of the local environment, the availability of solid waste collection (SWC) facilities, and their environmental concern. Thus, villagers’ SWC behaviors are mainly influenced by practical convenience and internal motivation. In general, government-relevant factors do not directly impact villagers’ SWC behaviors but significantly moderate villagers’ behaviors. Surprisingly, the variable of villagers’ education level is a significantly negative factor in affecting both RSWM attitudes and behaviors, implying that future RSWM policy measures should take consider democracy more and value villagers’ participation.
Treatment-free survival after discontinuation of immune checkpoint inhibitors in mNSCLC: a systematic review and meta-analysis
Authors: Hu Yue , Liu Shan , Wang Lixing , Liu Yu , Zhang Duohan , Zhao Yinlong 
Published: July 2023

BackgroundRecent research has suggested that patients with metastatic non-small cell lung cancer (mNSCLC) can achieve ongoing response after discontinuation of immune checkpoint inhibitor (ICI), but the best time to discontinue and the factors influencing efficacy remain unknown.MethodA systematic search was performed for prospective clinical trials in patients with mNSCLC treated with ICIs published up to July 10, 2022. Eligible studies reported treatment-free survival (TFS) after discontinuation of ICI in partial objective responders. We calculated objective response rate (ORR) and TFS using random-effects models with respective 95% confidence intervals (Cis), and performed subgroup analyses to discuss the specific associations between ORR and TFS and the associated influencing factors.ResultsAcross the 26 cohorts (3833 patients) included, the weighted mean ORR for all patients was 29.30% (95% CI 24.28% to 34.57%), with ICI plus chemotherapy (48.83%, 95% CI 44.36% to 53.30%) significantly higher than monotherapy (23.40%, 95% CI 18.53% to 28.62%). 395 patients were all patients who were complete or partial responders in the study, 194 discontinued ICI treatment, and nearly 35.5% achieved a durable response. No significant differences in TFS were found between subgroups according to the ICI regimen classification. Four cohorts of patients who completed 35 courses of treatment showed high levels of pooled TFS at 6 (80.18%, 95% CI 53.03% to 97.87%) and 12 months (66.98%, 95% CI 46.90% to 84.47%). Three cohorts of patients discontinued ICI treatment due to treatment-related adverse events (TRAEs) with the TFS rates at 6 (76.98%, 95% CI 65.79% to 86.65%) and 12 months (64.79%, 95% CI 50.20% to 78.19%).ConclusionPatients with mNSCLC were able to achieve ongoing responses after discontinuation of ICI. In conclusion, the results of this meta-analysis indicate that different treatment regimens, different drugs or different treatment durations may have an impact on TFS.
Health-related quality of life and its determinants among patients with psoriasis at a referral hospital in Northwest Ethiopia
Authors: Belachew Eyayaw Ashete , Chanie Gashaw Sisay , Gizachew Eshetie , Sendekie Ashenafi Kibret 
Published: July 2023

ObjectivesThis study assessed health-related quality of life (HRQoL) and its determinants among patients with psoriasis having follow-ups at the University of Gondar Comprehensive Specialized Hospital (UoGCSH).Design, setting, and participantsA cross-sectional institutional-based study was conducted at the dermatologic clinic of UoGCSH from June to August 2022. Four hundred eligible patients with psoriasis were included in the study using a systematic random sampling technique.The main outcome measuredThe Dermatology Life Quality Index (DLQI) measurement scale was used to assess HRQoL. The relationship between HRQoL and independent predictor variables was investigated using bivariable and multivariate logistic regression analyses. Statistical significance was defined as a p-value of &lt;0.05 at the 95% CI.ResultsOf the 422 study subjects approached, 400 respondents with psoriasis were included in the final analysis. The mean (±SD) age was 39.8 (±17.2) years, and 56% were women. The most commonly prescribed medications were topical corticosteroids (68.3 %). The mean (±SD) DLQI was 13.05 (7.82). More than three-fourths (78.5%) of the patients' HRQOL was affected, and its severity ranged from very large to extremely large. Being male (adjusted odd ratio) (AOR) = 0.373, 95% CI (0.171, 0.773), the use of alternative therapy (AOR) = 0.237, 95% CI (0.114, 0.494), duration of diseases (AOR) = 0.184, 95% CI (0.061, 0.557), duration on medication (AOR) =3.75, 95% CI (1.32, 10.73), presence of comorbidity (AOR) = 6.199, 95% CI (1.921, 20.00), and income were found to have a significant association with poor HRQoL.ConclusionPsoriasis patients had reduced HRQoL, which was lower than that of the normal population. The study identified that several variables contributed to this reduced HRQoL. Predictors that take into account interventions were essential for preserving patients' HRQoL.