bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhipicephalus sanguineus sensu lato exposed to a dichloromethane Acmella oleracea extract: Acaricide activity and morphophysiological evaluations
Authors: Oliveira Patrícia Rosa , Monteiro Odair , Rocha Claudia Quintino , Junior Lívio Martins Costa , Camara Marcos Bispo Pinheiro , Souza José Ribamar Lima , Sanches Gustavo Seron , maia José Guilherme 
Published: August 2023

Abstract

The present study verified the efficacy of a dichloromethane Acmella oleracea (L.) R. K. Jansen extract against semi-engorged R. sanguineus s. l. female ticks and the effects of different concentrations on the germ cells and midgut epithelium of these ectoparasites through morphological and histological analyses. In vitro bioassays were performed (adult immersion test). For the cytotoxic evaluations, the semi-engorged females were allocated into five groups. The findings indicate that the dichloromethane A. oleracea extract was highly efficient against semi-engorged R. sanguineus s. l. females at concentrations higher than 10 mg/mL. The best results were obtained at 25 mg/mL, with an efficacy rate of 95%. The cytotoxic tests indicate that assessed the A. oleracea extract caused extensive damages to germ cells and the midgut epithelium of R. sanguineus s. l. ticks. The treatment affected the fertility of these ectoparasites, reducing their capacity to produce viable eggs and form the embryo and, consequently, to develop new individuals. Additionally, the treatment with the extract fraction affected the ectoparasites’ nutrition, which could delay or impair their development, consequently decreasing their mobility to find a suitable host and preventing them from completing their life cycle and moving to the following instar. Thus, the dichloromethane A. oleracea extract is a promising and viable alternative to control R. sanguineus s. l. ticks
Distribution and Soil Transmission of Satsuma Dwarf Virus Strains in Mie Prefecture, Japan
Authors: Nakajima Kaori , Ichinokiyama Hiromichi , Tomimura Kenta , Susaki Noritaka , Iwanami Toru 
Published: August 2023

Abstract

Satsuma dwarf virus (SDV) and its strains including citrus mosaic virus (CiMV), navel orange infectious mottling virus (NIMV), Natsusdaidai dwarf virus (NDV), and Hyuganatsu virus (HV), are known to cause severe damages to citrus trees. The occurrence of SDV strains was investigated in 69 citrus orchards in Mie Prefecture, Japan, in 2010–2012. Forty-three of the orchards contained citrus trees infected with strains of SDV. The CiMV strain occurred most frequently in Mie Prefecture, followed by the SDV strain. An isolate of the NIMV strain was detected at two orchards in Mie Prefecture. This is the second occurrence of NIMV in a field outside of the original field in Wakayama Prefecture, following an occurrence in Ehime Prefecture. This is the first report of combined CiMV and NIMV infection of citrus. Our results reveal that the CiMV strain is widely distributed outside Wakayama Prefecture. Moreover, isolates of the CiMV strain that barely induce mosaic symptoms on the fruit rind were found to be widely distributed. Because CiMV causes milder foliar symptoms than does SDV, it is considered that milder CiMV isolates are widespread in Mie Prefecture. Trifoliate orange seedlings were planted near infected citrus trees growing on trifoliate orange rootstocks, and soil-transmission of the SDV and CiMV strains occurred within 1 year of planting. Because trifoliate orange is widely used as a citrus rootstock, similar infections may occur in citrus plants grafted onto this rootstock in fields containing infected citrus trees.
Analysis of Genetic Biomarkers, Polymorphisms in ADME-Related Genes and their Impact on Pharmacotherapy for Prostate Cancer
Authors: Rehman Khurram , Iqbal Zoya , Zhiqin Deng , Ayub Hina , Saba Naseem , Khan Muzammil Ahamd , Yujie Liang , Duan Li 
Published: August 2023

Abstract
Prostate cancer (PCa) is a non-cutaneous malignancy in males with wide variation in incidence rates across the globe. It is the second most reported cause of cancer death. Its etiology may have been linked to genetic polymorphisms, which are not only dominating cause of malignancy casualties but also exerts significant effects on pharmacotherapy outcomes. Although many therapeutic options are available, but suitable candidates identified by useful biomarkers can exhibit maximum therapeutic efficacy. The single-nucleotide polymorphisms (SNPs) reported in androgen receptor signaling genes influence the effectiveness of androgen receptor pathway inhibitors and androgen deprivation therapy. Furthermore, SNPs located in genes involved in transport, drug metabolism, and efflux pumps also influence the efficacy of pharmacotherapy. Hence, SNPs biomarkers provide the basis for individualized pharmacotherapy. The pharmacotherapeutic options for PCa include hormonal therapy, chemotherapy (Docetaxel, Mitoxantrone, Cabazitaxel, and Estramustine, etc), and radiotherapy. Here, we overview the impact of SNPs reported in various genes on the pharmacotherapy for PCa and evaluate current genetic biomarkers with an emphasis on early diagnosis and individualized treatment strategy in PCa.
Alarming signs detected in the small pelagic fishery on the west coast of Sri Lanka
Authors: Bandaranayake K. H.K. , Gunasekara S. S. , Haputhantri S. S.K. , Jayasinghe R.P.P.K. 
Published: August 2023

Abstract
Small pelagic fishery particularly on the west coast plays a vital role both in terms of livelihood and food security in Sri Lanka. The present study was carried out using the time series data on the west coast representing four fisheries districts; Kalutara, Colombo, Negombo, and Chialw of 2001–2020 extracted from the Small Pelagic Database of the National Aquatic Resources Research and Development Agency, Sri Lanka with an aim of exploring the present status of the fishery. The target fish groups in the fishery include sardines, herrings, anchovies, and mackerels which are mainly caught by outboard engine fiber-reinforced plastic boats with a wide mesh size range of gillnets. The recent five-year landings data indicated that the highest average Catch per Unit Effort (CPUE) occurred during the onset of the southwest monsoon and extended until the end of the northeast monsoon. During the recent decade, the CPUE of fishery exhibited greater inter-annual fluctuation, with an average of 66.7 ± 17.3 kg per trip. Moreover, the Mean Trophic Level (MTL) of the coastal fish landings ranged from 3.13 to 3.62 over the past two decades with the lowest record in 2014. The average MTL value forecast for 2022–2026 will be 3.38. Among the key stocks, Amblygaster sirm showed a diminishing trend in relative contribution and catch rate. Declining catch trends of key target species allied with the same trend in MTL could be considered as alarming signals which are indicating concerning implications for management strategies.
Brewed coffee quality: a novel perspective based on the chemometrics of sensory attributes
Authors: Oliveira Bruno Pereira , Buozzi Mário Trama , Pinto Vinicius Pereira , Yasuoka Fatima Maria Mitsue , Neto Jarbas C. Castro 
Published: August 2023

Abstract
Coffee is consumed by 98% of Brazilian and is considered the second most consumed beverage in the world and one of the most traded on the stock exchange. Brazil is one of the most important coffee producers, both in terms of consumption and exportation of the processed raw bean. There is complexity in the production chain as consumers look, for beverages that evoke memories and good feelings while enjoying a cup of coffee. The facts is, for the maintenance and standardization of the blends sold the SCAA protocol method, which assesses 11 qualitative and quantitative coffee requirements, generating a score. The higher the score, the better the coffee is considered. In this study, we present a statistical correlation analysis of variables that demonstrates that five requirements directly impact the final score of the coffee: aroma, balance, acidity, flavor, body, and sweetness, the latter being presented as neutral requirement. Another statistical analysis conducted compares the samples based on their origin. It was found that coffees from each country exhibit statistically significant variances, meaning that the overall score of the product differs noticeably depending on its structure. Lastly, it was understood that the Brazilian consumer prioritizes aroma as the main quality factor, whereas specialists consider it the fourth most important aspect in professional evaluations.
Factors associated with the risk of the incidence of heart failure in diabetic patients followed in Goma, Democratic Republic of the Congo
Authors: Mukoso Ferdinand Ng’ekieb , Nkodila Aliocha Natuhoyila , Kamuanga Zéphirin Tudienzela , Kapongo Remy Yobo , Mukad-Bamuleka Daniel , Kianu Bernard Phanzu , Situakibanza Hippolyte Nani tuma , Longo-Mbenza Benjamin , Wembomyama Stannislas Okitotsho , Tsongo Zacharie Kibendelwa 
Published: August 2023

Abstract
Background: The association between diabetes and heart failure is known in the literature, but data in Sub-Saharan Africa are limited. The objective of this study is to identify the clinical and hemodynamic factors associated with the incidence of heart failure in diabetics followed in Goma.
Methods: Asymptomatic diabetics in the city of Goma were cross-sectionally recruited at the Center of the Association of Diabetics in Congo (ADIC) in Goma, DRC during the period from February 5 to 19, 2023. The risk of insufficiency heart rate at 5 years was determined using BNP. A BNP value ≥50 pg/ml was considered an incidence of heart failure. The association between the incidence of HF and the independent variables was assessed using the logistic regression test, the best performing blood pressure component of the incidence of heart failure was assessed by the ROC curve and the area under the curve.
Results: The incidence frequency of heart failure was 29.98%. Analysis of the ROC curve showed that PP was the most important component of AP associated with a subsequent incidence of HF [AUC = 0.873; 95% CI: 0.829-0.916]. After adjusting for all these variables in a multiple logistic regression, age≥40 years (aOR: 2.02, 95% CI: 1.03-3.04) (p=0.024), female gender (aOR: 2.00, 95% IC: 1.24- 3.25) (p=0.005), PP≥65 mmHg (aOR: 2.63, 95% CI: 1.83-3.99) (p<0.001) and eGFR<60 mmHg (aOR: 1.99, 95% CI: 1.09-3.00) (p =0.037) were the independent risk factors associated with the incidence of HF in diabetics.
Conclusion: The frequency of HF is high in asymptomatic diabetics in Goma. It is associated with gender, age, PP and altered eGFR.
Community Detection in Hypergraphs via Mutual Information Maximization
Authors: Kritschgau Jurgen , Kaiser Daniel , Rodriguez Oliver Alvarado , Amburg Ilya , Bolkema Jessalyn , Grubb Thomas , Lan Fangfei , Maleki Sepideh , Chodrow Phil , Kay Bill 
Published: August 2023

Abstract
The hypergraph community detection problem seeks to identify groups of related nodes in hypergraph data. We propose an information-theoretic hypergraph community detection algorithm which compresses the observed data in terms of community labels and community-edge intersections. This algorithm can also be viewed as maximum-likelihood inference in a degree-corrected microcanonical stochastic blockmodel. We perform the inference/compression step via simulated annealing. Unlike several recent algorithms based on canonical models, our microcanonical algorithm does not require inference of statistical parameters such as node degrees or pairwise group connection rates. Through synthetic experiments, we find that our algorithm succeeds down to recently-conjectured thresholds for sparse random hypergraphs. We also find competitive performance in cluster recovery tasks on several hypergraph data sets.
Anodic oxidation of Esomeprazole in water by carbon coated titanium (C/Ti) electrode: Optimization and degradation analysis
Authors: Farissi Salman , Palasseri Harikrishnan , Gopi Utukuri , Ajith Gara , Muthukumar Anbazhagi , Muthuchamy Muthukumar 
Published: August 2023

Abstract

Esomeprazole (ESO) is a proton pump inhibitor(PPI) widely used to treat gastrointestinal inflammation and intense acidity. Due to high utilization rate, it is presently classified under the category of contaminants of emerging concern (CECs). Current study targets the removal of esomeprazole from water by electrochemical oxidation (EO). EO was applied by carbon coated titanium (C/Ti) anode and Titanium cathode with sodium sulfate electrolyte. Studies of optimization conducted using COD analysis found pH 3, 60 mM sodium sulfate concentration, 300 min treatment time and 115 mA.cm− 2 current density managed to remove 93% ESO from the sample. HPLC-PDA studies found 100% ESO removal while TOC analysis established only 44% mineralization. Degradation mechanism and pathway were proposed utilizing High resolution mass spectrometry (HRMS) studies. The major degradation mechanisms were demethylation, breaking away of sulfinyl benzimidazole group, desulfurization and the formation of thioperoxole group. The anode and cathode materials were reused more than 20 times without considerable decrease in its oxidation efficiency.
Genetic association between ICAM-1 gene variants and susceptibility to ischemic cardiomyopathy
Authors: Naman Tuersunjiang , Abuduhalike Refukaiti , Abudouwayiti Aihaidan , Abudoureyimu Muyassar , Sun Juan , Mahemuti Ailiman 
Published: August 2023

AbstractObjective:The current work was aimed at exploring the association between single nucleotide polymorphisms(SNPs) in the ICAM-1 gene, along with the identification of additional haplotypes and their potential role in susceptibility to Ischemic Cardiomyopathy（ICM）.Methods:The control group underwent a Hardy-Weinberg equilibrium test. The associations of genotypes and alleles with susceptibility to ischemic cardiomyopathy were then analyzed using logistic regression. Subsequently odds ratios(ORs) along with 95% confidence intervals (95% CI) were calculated. Interaction analysis was conducted between these SNPs. Furthermore, linkage disequilibrium analysis and haplotype analysis were performed on SNPs that showed interactions with each other.Results:The incidence of ICM was significantly higher among individuals carrying the T allele of rs3093032 (OR = 2.032, 95%CI = 1.275–3.241,P= 0.003)in relative to those with the C allele. Additionally, CT genotype carriers had a higher susceptibility to ICM than CC genotype carriers(OR = 2.490, 95%CI = 1.445–4.29,P= 0.001). Furthermore, three SNPs(rs3093032, rs923366, rs3093030) exhibited a strong interaction with each other, while rs281437 showed no interaction with the other three SNPs. Individuals carrying the Crs3093032-Trs923366-Crs3093030haplotype had an elevated risk of ICM compared with those carrying the Crs3093032-Crs923366-Crs3093030haplotype(OR:2.280, 95%CI:1.568–3.315,P<0.001). Moreover, individuals carrying the Trs3093032-Crs923366-Crs3093030haplotype were more susceptible to ICM than those carrying the Crs3093032-Crs923366-Crs3093030haplotype (OR:2.388,95%CI:1.469–3.880,P<0.001).Conclusion:Regarding rs3093032, individuals carrying the T allele exhibited a higher risk of ICM than those with the C allele. Moreover, CT genotype carriers were more susceptible to ICM than CC genotype carriers. Furthermore, individuals carrying the Crs3093032-Trs923366-Crs3093030and Trs3093032-Crs923366-Crs3093030haplotypes presented an elevated risk of developing ICM compared to carriers of the Crs3093032-Crs923366-Crs3093030haplotype. These findings provide valuable insights into the effects of ICAM-1 gene variants on the intricate pathogenic mechanisms underlying ICM.
Association between portal vein thrombosis after umbilical vein catheterization and neonatal asphyxia
Authors: Collela Marina , Zanin Anna , Toumazi Artemis , Bourmaud Aurélie , Boizeau Priscilla , Guilmin-Crepon Sophie , Leick Noémie , Khat Sophea , Alison Marianne , Baud Olivier , Biran Valérie 
Published: August 2023

Abstract

Background
Neonatal portal vein thrombosis (PVT) is frequently related to umbilical venous catheterisation (UVC) but risk factors remain unclear.
Objective
To analyse the variables associated to PVT in near to full term newborns with UVC, with a focus on newborns exposed to controlled therapeutic hypothermia (CTH) for hypoxic ischemic encephalopathy (HIE).
Methods
Retrospective cohort study of infants delivered at or after 36 weeks and with a birthweight over 1500g. All infants were assessed for UVC location and PVT using ultrasonography performed between day 5 and day 10 after catheterisation.
Results
Among 213 eligible patients, PVT was diagnosed in 57 (27%), among them 54 (95%) were localized in the left portal vein branch and 28 (49%) were of grade 1. With all significant factors in univariate analysis considered, higher gestational age at birth (adjusted OR 1.35; 95%CI: 1.12–1.64, P = .002) and duration of UVC placement (adjusted OR 1.36; 95%CI: 1.11–1.67, P = .004) were the main risk factors of PVT. Among 87 infants who were cooled for HIE, 31 (36%) had PVT compared to 26 (21%) in infants without CTH. Using a multivariate model including variables linked to treatment procedures only, an increased PVT incidence was statistically associated with UVC duration (adjusted OR 1.33; 95%CI: 1.08; 1.63, P = .01) and CTH (adjusted OR 1.94; 95%CI: 1.04–3.65, P = .04).
Conclusion
Left PVT was frequently observed in near to full term neonates with UVC. Among factors linked to treatment procedures, both duration of UVC and CTH exposure for HIE were found to be independent risk factors of PVT.
Estimating the impact of label design on reducing the risk of medication errors by applying HEART in drug administration
Authors: Aceves-Gonzalez Carlos , Caro-Rojas Angela , Rey-Galindo John A. , Aristizabal-Ruiz Luz , Hernández-Cruz Karen 
Published: August 2023

Abstract

Medication errors are one of the biggest problems in healthcare. The medicines ' poor labelling design (i.e., Look-Alike labels) is a well-recognised risk for potential confusion, wrong administration, and patient damage. Human Factors and Ergonomics (HFE) encourages the human-centred design of system elements, which might reduce medication errors and improve people's well-being and system performance.
Objective: The aim of the present study is twofold: (i) to use a human reliability analysis technique to evaluate a medication administration task within a simulated scenario of a Neonatal Intensive Care Unit (NICU); (ii) to estimate the impact of a Human-Centred Design (HCD) label in medication administration compared to a Look-Alike (LA) label.
Method: This paper used a modified Human Error Assessment and Reduction Technique (HEART) version to analyse a medication administration task in a simulated NICU scenario. The modified technique involved expert nurses quantifying the likelihood of unreliability of a task and rating the conditions, including medicine labels, which most affect the successful completion of the task.
Results: Findings suggest that Error Producing Conditions (EPCs), such as a shortage of time available for error detection and correction, no independent checking of output, and distractions, might increase Human Error Probability (HEP) in administering medications. Results also showed that the assessed HEP and the relative percentage of contribution to unreliability reduced by more than 40% when the HCD label was assessed compared to the LA label.
Conclusion: Including labelling design based on HFE might help increase human reliability when administering medications under critical conditions.
Photo-driven Interfacial Electron Transfer Reduction of cis-[Co(phen) 2 Cl 2 ]Cl Complex by Heterojunctioned CeO 2 /SnO 2 Nanocomposite with Insight on the Role of Supercapacitance
Authors: Silambarasan R. , Pavalamalar S. , Siva Uttej , Anbalagan K 
Published: August 2023

Abstract
Nano CeO2/SnO2 composite was successfully synthesised using the hydrothermal method. Nano-CeO2/SnO2 is one of the most widely used photocatalysts in metal oxide-semiconductors and has good photocatalytic activity. Experimental and spectroscopic approaches confirmed the structure and shape of the nanocomposite according to X-ray diffraction, transmission electron microscopy and scanning electron microscopy results. Spectral peaks are shown to migrate with the CeO2/SnO2 composite in experiments using Raman and opacity (PL). The magnetic properties of SnO2 (20.54 emu/g) are higher than CeO2 (6.875 emu/g) nanoparticles and nanocomposite (4.822 emu/g). The different oxidation states of Ce and Sn, which act as active sites in the electrocatalytic activity of this nanocomposite material, were observed using X-ray photoelectron spectroscopy (XPS). The capability of the CeO2/SnO2 composite was demonstrated by additional galvanic charge-discharge experiments at various current densities, cyclic voltammetry measurements at various scan rates (the maximum capacitance value of 718 Fg− 1 from CV and 721 Ag− 1 from GCD). Surface absorption of cis-[Co(phen)2Cl2]Cl curve with binary solvent catalysis, measured the rate (k = 0.0032 sec− 1). Reduction of cis-[Co(phen)2Cl2]Cl by nano-CeO2/SnO2 was traced to the production of Co(II) ion, which was shown to be catalytically efficient by UV-Vis response curves. Lattice analysis showed that the catalytic activity was very effective in binary solvent solution (H2O/PriOH) (254 nm and 365 nm lamp, k = 0.0625 sec− 1 and k = 0.0305 sec− 1) and then in pure water (k = 0.0018 sec− 1). Thus, the enhanced photocatalytic activity of the nano-CeO2/SnO2 material can be attributed to the excellent charge separation and electron transport for reduction efficiency of the photogenerated charge carriers.
A mild and eco-friendly, one-pot synthesis of 2-hydroxy-N-arylacetamides from 2-chloro-N-arylacetamides
Authors: Radhakrishna Vamshikrishna Y. , Khatik Gopal L. , Vijaya Bhuvaneshwari S. , Nair Vipin A. 
Published: August 2023

Abstract
A mild and eco-friendly one-pot two-step procedure was developed for the synthesis of 2-hydroxy-N-arylacetamides from 2-chloro-N-arylacetamides. The procedure overcomes the cleavage of the amide linkage in 2-chloroacetamides which is usually observed under reflux condition with the hydroxide when the nucleophilic substitution of the halide is attempted. The reactions were performed by refluxing 2-chloro-N-arylacetamides with Cu(OAc)2 and DIPEA in ethanol medium to facilitate an acetate exchange with the halogen. Subsequently by the addition of ethanolic KOH solution to the same reaction flask the ester linkage was selectively cleaved in the presence of the amide taking advantage of the difference in electrophilicity. The procedure affords good yields of the desired products which are valuable intermediates for several biologically active molecules, in short reaction time with ease of isolation The experimental conditions employed are simple and offers the possibility of scale up to higher quantities.