bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tactical Features of Operation of the Specialized Anti-Epidemic Team of the Rospotrebnadzor on the Territory of the Republic of Crimea under Conditions Characteristic of a Combined Emergency
Authors: Soboleva E. G. , Kuznetsova D. A. , Kruglikov V. D. , Pichurina N. L. , Dobrovol’sky O. P. , Sokirkina E. N. , Tikhonov S. N. , Pen’kovskaya N. A. , Noskov A. K. 
Published: July 2023

The tactics of activities of the specialized anti-epidemic team (SAET) of the Rospotrebnadzor on the territory of the Republic of Crimea has been determined by the conditions of emergency situation of sanitary-epidemiological and natural character. The aim of the work was to analyze the features and effectiveness of the functional response of the Rospotrebnadzor SAET to the dynamics of epidemiological risks caused by emergency of combined nature in the Republic of Crimea in 2020–2021. Materials and methods. We used report materials of the Rospotrebnadzor SAET; information materials of the Interregional Rospotrebnadzor Administration in the Republic of Crimea and the Federal city of Sevastopol; “Coronavirus Monitor” service data. Results and discussion. Tactical decisions on the work of the SAET on the territory of the Republic of Crimea had the stage-by-stage nature. In the event of a complication of the epidemiological situation on the new coronavirus infection, a mobile group of the SAET was involved. Together with specialists from the Plague Control Station of the Republic of Crimea, it conducted 211 148 studies of clinical material to detect SARS-CoV-2 RNA using PCR during the period of 2020–2021. In response to the emergence of additional risks caused by the consequences of a dangerous meteorological phenomenon, the group of SAET specialists was reinforced and mobile complex (MС) of the SAET was deployed. During the entire course of work, a prolonged target rotation of personnel was implemented in order to provide for adequate laboratory support for monitoring upon epidemiological indications in accordance with the nature of emerging risks. That tactics of operation made it possible to conduct 18 591 screening studies of clinical material for acute respiratory viral infections (ARVI), natural-focal and acute intestinal infections (AII), as well as the study of 280 water samples for cholera. Introduction of the sequence of operational procedures adapted for work in emergency situations resulted in isolation of 10 Vibrio cholerae O1 ctxA–</sup tcpA–/em> strains from water bodies. The phased involvement of the mobile group of SAET specialists, and later the MC of the SAET, in combination with the consistent operational target rotation of personnel in order to provide adequate laboratory support for monitoring studies, determined the tactical features of the SAET functioning. Prompt investigation, substantiation of potential and response to realized (actual) epidemiological risks associated with the extraordinary situation made it possible to prevent complications of the epidemiological situation in the territory of the tourist cluster of the Russian Federation.
OPTIMASI KUAT TEKAN DAN PENYERAPAN AIR PAVING BLOCK MENGGUNAKAN AKS ADDITIVE
Authors: Mulyati Mulyati , Nurul Fausi Muhammad 
Published: July 2023

Penelitian ini menggunakan AKS additive sebagai bahan tambah untuk campuran pembuatan paving block. Tujuan dari penelitian ini adalah untuk mengetahui nilai kuat tekan dan penyerapan air paving block optimum dari penambahan AKS additive ke dalam bahan campuran pembuatan paving block. Perbandingan campuran semen dan pasir dalam pembuatan paving block digunakan 1:3, dan penambahan AKS additive 0%, 1,6%, 1,7%, 1,8%, 1,9%, dan 2,0% dari berat semen. Benda uji paving block menggunakan cetakan dengan ukuran 20 cm x 10 cm x 6 cm. Pengujian kuat tekan dan penyerapan air paving block dilakukan pada umur 28 hari. Hasil penelitian menggunakan AKS additive sebagai bahan tambah campuran pembuatan paving block dapat meningkatkan kuat tekan dan menurunkan penyerapan air. Kuat tekan rata-rata tertinggi sebesar 12,67 MPa dan penyerapan air rata-rata terendah sebesar 7,06% diperoleh pada penggunaan 1,9% AKS additive, memenuhi persyaratan paving block mutu C digunakan untuk trotoar atau pejalan kaki.
Analisis Faktor Makro Ekonomi Yang Mempengaruhi Penerimaan Zakat, Infak, dan Shadaqah di Indonesia Tahun 2005-2019
Authors: Yanti Dharma , Parlina Tika 
Published: July 2023

This study aims to determine the macroeconomic factors that affect the acceptance of Zakat, Infaq and Sadaqah in Indonesia. This study uses quantitative research methods with path analysis. The independent variables in this study are the rate of economic growth, number of working population, GDP/capita, provincial minimum wage. While the dependent variable is the amount of zakat, infaq and shadaqah receipts. The results showed that all variables had a significant effect on the acceptance of zakat, infaq, and shadaqah. However, after going through path analysis, it is known that the rate of economic growth (X1) and GDP/capita (X3) has a negative and significant effect on zakat, infaq, and shadaqah receipts, while the number of working population (X2) and the provincial minimum wage (X4) have an influence. positive and significant to the acceptance of Zakat, Infaq, and Sadaqah.
Keywords : Zakat, Infaq, Shadaqah, Economic Growth, GDP.
Pengaruh Lingkungan Kerja dan Budaya Organisasi Terhadap Kinerja Pegawai Pada Universitas Islam Negeri(UIN) Sultan Aji Muhammad Idris Samarinda
Authors: Nurhaedah Nurhaedah , Parno Parno , Tikawati Tikawati , Noni Yovanda 
Published: July 2023

Budaya yang kuat dapat mempengaruhi kinerja bahkan di lingkungan perusahaan atau Lembaga-Lembaga lebih besar pengaruhnya terhadap persaigan, seperti struktur organisasi, alat analisis keuangan, dapat menyesuaikan dengan perubahan jaman yang dapat meningkatkan kinerja. Tujuan penelitian ini untuk mengetahui Pengaruh Lingkungan Kerja dan Budaya Organisasi terhadap Kinerja Pegawai pada Universitas Islam Negeri (UIN) Sultan Aji Muhammad Idris Samarinda. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif. Teknik pengambilan sampel menggunakan sampling jenuh.
Hasil penelitian ini menunjukan bahwa Lingkungan Kerja dan Budaya Organisasi berpengaruh secara signifikan terhadap Kinerja Pegawai pada Universitas Islam Negeri (UIN) Sultan Aji Muhammad Idris Samarinda X1 sebesar 5,029 > ttabel 2,228. Sehingga dapat disimpulkan bahwa H1 diterima dan H0 ditolak. Jadi dapat dikatakan bahwa variabel X1 memiliki konstribusi terhadap Y. Yang berarti Kepemimpinan X1 berpengaruh terhadap Kinerja Pegawai (Y) Budaya Organisasi X2 sebesar 2.465 > ttabel 2,228. Sehingga dapat disimpulkan bahwa H2 diterima dan H0 ditolak. Jadi dapat dikatakan bahwa variabel X2 memiliki konstribusi terhadap Y. Secara Simultan Lingkungn kerja dan Budaya Organisasi berepengaruh terhadap Kinerja Pegawai Berdasarkan pada tabel di atas, dapat disimpulkan dalam pengujian secara simultan variabel lingkungan kerja X1, dan budaya organisasi X2, terhadap kinerja pegawai Y, diperoleh nilai Fhitung sebesar 43,213 untuk mengetahui nilai F tabel, F = (n-k). F (81 - 2) F= (2;79) = 3,110. Dengan nilai probabilitas sig = 0,05. Maka Fhitung 43,213 > Ftabel = 3,110 dan nilai sig lebih kecil dari nilai probabilitas 0,05 atau nilai 0,000 < 0,05. Maka Ho ditolak dan Ha diterima. Sehingga dapat disimpulkan bahwa variabel lingkungan kerja, dan budaya organisasi secara bersama-sama (simultan) berpengaruh signifikan terhadap kinerja pegawai (Y).
Pengaruh Bauran Pemasaran Islami Terhadap Keputusan Pembelian Hijab Di Big Mall Samarinda
Authors: Sarnining Sarnining , Iswadi Muhammad , Yusran Yusran 
Published: July 2023

Abstract
The purpose of this study is to determine the product, price, place, and promotion partially and simultaneously have a significant effect on purchasing decisions for hijab at Big Mall Samarinda.
This study uses quantitative methods because it emphasizes testing theories through measuring research variables by analyzing data with statistical procedures. In this study, four variables X and Y variables were used, namely the product variable (X1), price (X2), place (X3), promotion (X3), and purchase decision (Y). The types of data used in this study are primary and secondary data. The sampling method used is by using the Cochran formula with a sample of 100 respondents. The method of data collection in this study used observation, questionnaires/questionnaires and documentation. The data analysis technique in this study uses a validity test, reliability test, classical assumption test consisting of (normality test, multicollinearity, heteroscedasticity, linearity, and autocorrelation), and multiple linear regression analysis test consisting of (t test, F test, and test R).
The results of this study indicate that the product variable partially has a significant effect on purchasing decisions with a significant value of 0.043 ≤ 0.05, the price variable partially has no significant effect on purchasing decisions with a significant value of 0.733 ≥ 0.05, the place variable partially has a significant effect on decisions. purchases with a significant value of 0.000 ≤ 0.05, the promotion variable partially has a significant effect on purchasing decisions with a significant value of 0.000 ≤ 0.05. The results of this study indicate that the product, price, place, and promotion variables simultaneously have a significant effect on purchasing decisions with a significant value of 0.000 ≤ 0.05. The effect of all variables in this study was 73.4% while 26.6% was influenced by other variables.
Keywords: Islamic Marketing Mix on Purchase Decision
Inclusion of Definitions in Legislative Drafting: A Necessity or a Luxury?
Authors: Ezzerouali Souad , Chami Yassine 
Published: July 2023

Legislative drafting is a crucial element in the formation of legal norms. The success of these norms depends on the accuracy of the words used and the appropriateness of its tools, as it is subject to a set of rules and mechanisms that the legislator must follow, whether at the level of form or at the level of content. Our study will focus on the rule related to using definitions in the exact way to include them in the legislative drafting. It aims to standardize the terms used by the legislator in the legal text in order to avoid any confusion or ambiguity about these terms, and to distinguish it from other meanings that may come in other texts but in a different concepts. The research problem revolves around the extent to which legislation needs to include definitions in laws, is it a necessity or just a luxury? We will address this problem using the descriptive and comparative approach by dividing the study into two parts, the first part deal with the need to include definitions in laws, and the second part addresses the norms governing the use of definitions in legislative drafting. We conclude, that adding a legal definition to the legislative process, giving it legal meaning, would perpetuate the rigid, ossified concept of law. Contrast that with jurisprudential definitions, which sometimes change the true meaning of jurists' terms. However, each definition will be kept in line with the pace of legislation to keep up with the pace of social development, in case it becomes outdated or needs to be supplemented.
Keywords: legal drafting, definitions, improvement of law, legal security.
Risk factors for osteoporotic hip fracture among community-dwelling older adults: a real-world evidence study
Authors: Azevedo Daniela Castelo , Hoff Leonardo Santos , Kowalski Sergio Candido , de Andrade Carlos Augusto Ferreira , Trevisani Virgínia Fernandes Moça , de Melo Ana Karla Guedes 
Published: July 2023

Abstract
Background
Hip fractures in the older adults lead to increased morbidity and mortality. Although a low bone mineral density is considered the leading risk factor, it is essential to recognize other factors that could affect the risk of hip fractures. This study aims to evaluate the contribution of clinical characteristics, patient-reported outcomes, and muscle and aerobic capacity for hip fractures in community-dwelling older adults.
Methods
This is a retrospective cohort study with real world-data from subjects ≥ 60 years old attending an outpatient clinic in Minas Gerais, Brazil, from May 1, 2019, to August 22, 2022. Data about clinical characteristics (multimorbidity, medications of long-term use, sedative and or tricyclic medications, number of falls), patient-reported outcomes (self-perception of health, self-report of difficulty walking, self-report of vision problems, and self-report of falls) and muscle and aerobic capacity (calf circumference, body mass index, and gait speed) were retrieved from an electronic health record. The association of each potential risk factor and hip fracture was investigated by a multivariable logistic regression analysis adjusted for age and sex.
Results
A total of 7,836 older adults were included with a median age of 80 years (IQR 72–86) and 5,702 (72.7%) were female. Hip fractures occurred in 121 (1.54%) patients. Multimorbidity was associated with an increased risk of hip fracture (OR = 1.12, 95%CI 1.06–1.18) and each episode of fall increased the chance of hip fracture by 1.7-fold (OR = 1.69, 95%CI 1.52–1.80). Patient-reported outcomes associated with increased fracture risk were regular or poor self-perception of health (OR = 1.59, 95%CI 1.06–2.37), self-report of walking difficulty (OR = 3.06, 95%CI 1.93–4.84), and self-report of falls (OR = 2.23, 95%CI 1.47–3.40). Body mass index and calf circumference were inversely associated with hip fractures (OR = 0.91, 95%CI 0.87–0.96 and OR = 0.93, 95%CI 0.88–0.97, respectively), while slow gait speed increased the chance of hip fractures by almost two-fold (OR = 1.80, 95%CI 1.22–2.66).
Conclusion
Our study reinforces the importance of identified risk factors for hip fracture in community-dwelling older adults beyond bone mineral density and available fracture risk assessment tools. Data obtained in primary care can help physicians, other health professionals, and public health policies to identify patients at increased risk of hip fractures.
Novel compound missense variants in MUSK impair LRP4-MUSK-DOK7 complex associated with congenital myasthenic syndrome 9 and insights into genotype-phenotype correlation
Authors: Qian Yanyan , Jiang Yinmo , Zhou Wenhao , Wu Bingbing , Wang Huijun 
Published: July 2023

AbstractBackground:Congenital myasthenic syndromes are a group of rare neuromuscular transmission disorders. The muscle-specific kinase gene MUSK is one of the disease-causing genes.Method:Trio whole exome sequencing was performed in a patient family with congenital laryngeal achondroplasia. In vitro experiments in HEK293T cells were performed to evaluate the mutant proteins' subcellular distribution and the interactions with LRP4 and DOK7. Furthermore, we reviewed the genotype-phenotype correlations of MUSK variants from the reported literature and our patient.Result:Two novel missense variants, c.1043A>C(p.Gln348Pro) and c.2360C>T(p.Ala787Val) of MUSK, were detected in an 11-month-old girl. The variants were inherited from maternal and paternal, respectively. Compared with the wild-type MUSK protein, the two variants overexpressed in HEK293T cells localized in cytoplasmic rather than the cell membrane. The Gln348Pro was detected to impair the interaction with LRP4 and DOK7 partly. The Ala787Val variant was detected to impair the interaction with DOK7 completely. The genotype-phenotype analysis demonstrated that patients with biallelic truncation variants had earlier onset age than those with biallelic missense variants or missense variants with truncation variants. While considering biallelic missense variants, we found that the patients with variants localized in the tyrosine kinase domain had earlier onset age than those carrying variants in the Ig-like domain and had a higher mortality rate.Conclusion:In this study, we identified two novel MUSK variants cause severe fatal CMSs, expanding the spectrum of MUSK variants. In addition, our data suggest that the null variants or missense variants localized in tyrosine kinase might lead to more severe outcomes, which could give some reminders in prognostication.
Optimization Method of The Clamping Force for Large Cabin Parts
Authors: Yao Shuangji , Luan Yijv , Ceccarelli Marco , Carbone Giuseppe 
Published: July 2023

Abstract
In order to realize a stable clamping of the large cabin part, this paper studied the optimization of the clamping force for the clamping mechanism of the large-mass and large-size cabin part. Firstly, three kinds of contact models are introduced. Then a clamping matrix is constructed for a particular clamping configuration and the nonlinear friction cone constraint at the contact point is transformed into a linear affine constraint in a smooth Riemannian manifold by using the special structure of the positive definite symmetric matrix. Finally, a large cabin part in the aerospace field is used as an example for calculation and simulation of the clamping force optimization. Different optimization algorithms are used to calculate the initial value which will be put into the gradient flow optimization method of the clamping force for optimization calculation. The numerical results and curves show that the gradient flow optimization method of the clamping force can quickly complete the clamping force optimization of the large-mass and large-size cabin part. The distribution of the normal force of the clamping mechanisms and the convergence value of the clamping force for each clamping mechanism can provide some references for determining the output clamping force of the clamping mechanism and confirming a reasonable distribution of the clamping mechanism. It also proved the feasibility and effectiveness of this method applied in the clamping force optimization for the large axial part.
Epigenetic Reshaping through Damage: Promoting Cell Fate Transition by BrdU and IdU Incorporation
Authors: Liu Jing , Li Chuang , Chen Shuyan , Xu Xiaoduo , Guan Tongxing , Xu Anchun , li chen , yu shengyong , Wu Haokaifeng , Pei Duanqing 
Published: July 2023

Abstract
Thymidine analogs have long been recognized for their ability to randomly incorporate into DNA. However, their significance in the chemical induction of pluripotency (CIP) remains unclear. Here, we investigated the impact of BrdU/IdU incorporation on the transition of cell fate through DNA damage repair (DDR). Our findings reveal a substaintial upregulation of reprogramming mediator gene H3K27ac and H3K9ac, as well as global DNA demethylation in response to DDR. This process creates a hypomethylated environment that promotes cell fate transition. We term this mechanism as Epigenetic Reshaping through Damage (ERD). Overall, our study sheds light on the dynamic interplay between thymidine analogs, DDR, and epigenetic modifications, providing valuable insights into the mechanisms underlying cell fate transition.
Oceanic Anoxic Event 2 triggered by Kerguelen Plateau volcanism
Authors: Walker-Trivett Chloe , Kender Sev , Bogus Kara , Littler Kate , Edvardsen Trine , Leng Melanie , Lacey Jack 
Published: July 2023

Abstract

Large Igneous Province (LIP) volcanism is thought to have been the main cause of global warming, ocean anoxia and carbon cycle perturbations associated with Cretaceous Oceanic Anoxic Event 2 (OAE2, ~94 Ma). However, there is still no consensus on the timing and role volcanism played in triggering carbon cycle changes, or the source of the volcanism that has been previously ascribed to either the Caribbean LIP or High Arctic LIP. Here, we refine the stratigraphic position of OAE2 and the Mid-Cenomanian Event (MCE, ~96.5 Ma) at two sites in the Mentelle Basin (offshore southwestern Australia), and use sedimentary mercury (Hg) abundance to determine the timing of volcanism. Contrary to many Northern Hemisphere records, we report elevated levels of Hg and Hg/total organic carbon (TOC), suggesting OAE2 was initiated by a volcanic source proximal to the Mentelle Basin, such as the Kerguelen LIP. Distinct Hg/TOC pulses preceding the onset of OAE2, and in conjunction with its main phase, suggest volcanic emissions played a central role in triggering and controlling climatic and carbon cycle changes within OAE2. By contrast, we find little evidence to suggest a Southern Hemisphere volcanic episode initiated the MCE. Benthic foraminiferal assemblages and bulk sediment isotopes indicate volcanism caused elevated productivity and probable upwelling in the Southern Hemisphere Mentelle Basin for the duration of OAE2, similar to Northern Hemisphere records.
MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling
Authors: Lin Yea-Lih , Técher Hervé , Gopaul Diyavarshini , Heuzé Jonathan , Leray Baptiste , Vernet Audrey , Mettling Clément , Moreaux Jérôme , Pasero Philippe 
Published: July 2023

Abstract

Oncogene-induced senescence (OIS) arrests cell proliferation in response to replication stress (RS) induced by oncogenes. OIS depends on the DNA damage response (DDR), but also on the cGAS-STING pathway, which detects cytosolic DNA and induces type I interferons (IFNs). Whether and how RS and IFN responses cooperate to promote OIS remains unknown. Here, we show that the induction of OIS by the H-RASV12 oncogene in immortalized human fibroblasts depends on the MRE11 nuclease. Indeed, treatment with the MRE11 inhibitor Mirin prevented RS, micronuclei formation and IFN response induced by RASV12. Overexpression of the cytosolic nuclease TREX1 also prevented OIS. Conversely, overexpression of a dominant negative mutant of TREX1 or treatment with IFN-β was sufficient to induce RS and DNA damage, independent of RASV12 induction. These data suggest that the IFN response acts as a positive feedback loop to amplify DDR in OIS through a process regulated by MRE11 and TREX1.
Original research; Evaluation of isolation support packages for young people in Lancaster District
Authors: Robin Charlotte , Taylor Jo , Inston Fiona 
Published: July 2023

Abstract
Objective
To evaluate if offering incentives to young people testing positive for Covid-19 impacts on their adherence with self-isolation and associated impact on their health and wellbeing through isolation
Design:
Non-randomised controlled trial
Setting:
Lancaster district area
Participants:
450 young people (aged 10–16 years) who were Covid positive from 17th January 2022 to 24th February 2022 divided into four groups based on their postcode. A mixed method approach with data collected via survey and focus groups.
Intervention:
Four groups: Group one received an activity pack and thank you gift for self-isolating (enhanced package); Group two received a thank you gift only; Group three received an activity pack only; Group four received no intervention (control group).
Results
The participants from the survey (n = 141) and the focus groups (n = 17) described the adverse impact of self-isolation of feeling lonely, isolated and missing friends and family and going out. The participants reported the best part of self-isolation was missing school, staying in bed and having more time to themselves. Participants who received the interventions reported it had a positive impact on their health and wellbeing.
Conclusions
This research highlights the importance of offering support to young people during isolation to reduce the negative impact on health and wellbeing and to motivate adherence by providing incentives. The research contributes to the learning on how to support young people to self-isolate with other infectious diseases and any future public health emergencies.