bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Arginase Inhibitor, AZD0011, Demonstrates Immune Cell Stimulation and Antitumor Efficacy with Diverse Combination Partners
Authors: Doshi Aatman S. , Cantin Susan , Hernandez Marylens , Srinivasan Srimathi , Tentarelli Sharon , Griffin Matthew , Wang Yanjun , Pop-Damkov Petar , Prickett Laura B. , Kankkonen Cecilia , Shen Minhui , Martin Maryann San , Wu Song , Castaldi M. Paola , Ghadially Hormas , Varnes Jeffrey , Gales Sonya , Henry David , Hoover Clare , Mele Deanna A. , Simpson Iain , Gangl Eric T. , Mlynarski Scott N. , Finlay M. Raymond V. , Drew Lisa , Fawell Stephen E. , Shao Wenlin , Schuller Alwin G. 
Published: March 2023

Abstract
Antitumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment, including recruitment of arginase (ARG) expressing myeloid cells that deplete l-arginine essential for optimal T-cell and natural killer cell function. Hence, ARG inhibition can reverse immunosuppression enhancing antitumor immunity. We describe AZD0011, a novel peptidic boronic acid prodrug to deliver an orally available, highly potent, ARG inhibitor payload (AZD0011-PL). We demonstrate that AZD0011-PL is unable to permeate cells, suggesting that this compound will only inhibit extracellular ARG. In vivo, AZD0011 monotherapy leads to arginine increases, immune cell activation, and tumor growth inhibition in various syngeneic models. Antitumor responses increase when AZD0011 is combined with anti–PD-L1 treatment, correlating with increases in multiple tumor immune cell populations. We demonstrate a novel triple combination of AZD0011, anti–PD-L1, and anti-NKG2A, and combination benefits with type I IFN inducers, including polyI:C and radiotherapy. Our preclinical data demonstrate AZD0011’s ability to reverse tumor immunosuppression and enhance immune stimulation and antitumor responses with diverse combination partners providing potential strategies to increase immuno-oncology therapies clinically.
Satyr-Play in the Statesman and the Unity of Plato’s Trilogy
Authors: El Murr Dimitri 
Published: March 2023

Abstract
At Statesman (Plt.) 291a–c and 303c–d, Plato compares the so-called statesmen of all existing constitutions to a motley crew of lions, centaurs, satyrs, and other beasts, and the entire section of the Statesman devoted to law and constitutions (291c–303c) to a satyr-play of sorts. This paper argues that these thought-provoking images are best understood as literary devices which, in addition to other dramatic elements in the Theaetetus and Sophist, help to bolster the unity of the Theaetetus-Sophist-Statesman trilogy and its apologetic agenda concerning Socrates.
Essentialism in the Categories
Authors: Shapiro Gabriel 
Published: March 2023

Abstract
According to the Categories, predicates can be ‘said of’ their subjects or they can be ‘present in’ their subjects. The said-of relation has received relatively little scholarly attention, and scholars disagree on the answers to four foundational questions about the relation. (i) What is it? (ii) Is it an essential relation? (iii) How is it related to predication? (iv) Is it primitive? I argue that A is said-of B just in case A is a formal part of B. On this account, said-of is an essential relation and it is definable, but it is not defined in terms of predication.
Keeping treasure safe: Eurasian red squirrels cache valuable food far from the food source with low canopy cover
Authors: Takahata Yu , Uchida Kenta , Shimamoto Tatsuki , Kutsukake Nobuyuki 
Published: March 2023

Abstract
Scatter-hoarding animals decide their food hoarding location by assessing food quality and pilfering risk. Previous studies have proposed two non-mutually exclusive hypotheses; the optimal density model (ODM) and the habitat structure hypothesis (HSH). The ODM proposes that animals utilize low cache density to protect their valuable caches by transporting food far from food sources. The HSH proposes that animals utilize predation risk to protect their valuable caches by hoarding food in open areas. Here, we investigated the hoarding behaviours in Eurasian red squirrels Sciurus vulgaris by experimentally providing high-quality (walnuts) and low-quality (acorns) food, to examine if they follow ODM or HSH. Compared to acorns, squirrels hoarded walnuts in places further from the area where food was provisioned and in areas with low canopy cover. These results agree with both ODM and HSH, providing the first evidence that hoarding behaviour in Eurasian red squirrels is shaped by multiple factors.
Seeking Justice for Women: Potential and Limits of International Solidarity Movements
Authors: Marconi Rachele 
Published: March 2023

Abstract
The contribution aims at analysing the role of international solidarity movements in seeking justice for international war crimes against women. Through the example of the ‘comfort women’ case, the article examines the ways in which these international solidarity movements have used international law instruments and institutions to promote the idea of an individual right to reparation as a means by which victims can obtain justice. Two specific legal features of this case show the international solidarity movements’ engagement with international law over the last decades: first, the establishment of the Women’s Tokyo Tribunal, and, second, the judicial mobilisation of international civil society actors before national courts. It is argued that the international solidarity movements have informed the legal concepts, paradigms, and language used to legally analyse the ‘comfort women’ case, and, to a certain extent, they have influenced some recent jurisprudential developments, especially in the legal arguments invoked by the national courts that have decided on the claims of ‘comfort women’. Ultimately, the ‘comfort women’ case demonstrates how the solidarity of international civil society actors towards a specific group of victims can be essential in order, first, to achieve post-conflict justice and, second, to progressively develop international law towards the advancement of legal standards of protection for individuals.
Taking Illegal Amnesties Seriously: Threefold Approach to the Admissibility Test before the International Criminal Court
Authors: Ochi Megumi 
Published: March 2023

Abstract
The current oversimplification of the amnesty issue has created a narrative that international law prohibits granting and admitting the effect of amnesties for core crimes. However, even if a domestic amnesty is found illegal under international law, it is still valid at the national level. The International Criminal Court (icc) cannot ignore the existence of and the legal consequences of such ‘illegal’ amnesties in assessing the admissibility of a case. This article categorises amnesties into three types and clarifies the legal and factual effects of internationally illegal domestic amnesties for the icc and the legal logic under which the icc treats such amnesties at the admissibility stage based on the developing applicable laws. This study provides clear guidelines on the conditions that would make a case inadmissible before the icc for both the chambers and the domestic policy makers and legislators who design amnesties.
The sociopragmatics of compliment in the media discourse
Authors: Tang Chihsia 
Published: March 2023

Abstract
This study investigated whether and how the gender of the judges in the TV talent competitions affects the pragmatics of the compliments in their evaluative comments addressed to the contest participants. The explicitness of the compliments, the distribution of positive semantic carriers and intensifiers, the personal focus of the compliments, and the supportive discursive moves in the male and female judges’ complimenting speech events were qualitatively analysed and statistically compared. Results, however, do not support the general belief that women’s complimenting style is more socioemotional than men’s. The function of the compliments that the judges would like to accentuate in the formal institutional setting appears to have a greater impact on their linguistic performances than their gender role. The male and female judges’ complimenting styles seem to be strategic manoeuvres to create their preferred social image in the public media discourse.
The Influence of Mongolian Nomadic Cattle Breeding on Language Use
Authors: Oberfalzerová Alena 
Published: March 2023

Abstract
The Mongolian nomads’ way of life and perception of the outside world is directly reflected in their thinking and use of language. In the following article, I apply an ethnolinguistic approach to the study of the Mongolian language. I find the theoretical basis in the ethnography of communication (Dell Hymes 1962), which allows for the communication behaviour of nomads to be revealed. The given examples of idioms, phrases, sayings, and proverbs relate to cattle breeding, the essence of nomadic life, and reveal the linguistic means of their metaphorical expression. The article builds on my previous ethnolinguistic research on the colloquial language and is based on material collected during long-term field research, which was subsequently consulted in detail with native speakers.
On a Sound Change in Proto-Turkic
Authors: Ünal Orçun 
Published: March 2023

Abstract
The present paper argues for two radical consonantal changes in Late Proto-Turkic, which can be formulated as *t₁ > g /V_iVr₁/₂ and *d₁ > g /V_iVr₁. Using this new sound law, some lexemes that have the phonemic shape /°VgVr/ or /°VgVz/ in Common Turkic are etymologised as being derived from verbs ending in °t- or °d-. The reconstructed Turkic forms are also partly supported by Mongolic data.
The variability of diagnosed migraine epidemiology amongst different municipalities in southern Israel
Authors: Peles Ido , Asla Mohnnad , Abayev Mariya , Gordon Michal , Alhoashle Ali , Novack Victor , Ribalov Rinat , Lengil Tamar , Maor Ron , Elizur Mayera , Ifergane Gal 
Published: March 2023

Abstract
Background
Appropriate and timely diagnosis is one of the most important milestones in effective migraine care and is affected by public awareness, access to medical care, health care systems, and physicians’ knowledge. We assessed the variability in migraine diagnosis rates in different communities under universal national health coverage in Israel.

Methods
In this population-based retrospective, observational, cohort study, adult (≥18 years) migraine patients were identified in the computerized database of the southern district of the Clalit Health Services Health Maintenance Organization (HMO) based on recorded diagnosis and/or purchase of specific anti-migraine acute medication (triptans). Migraine prevalence in 2018 was calculated in the entire study population and in different municipalities. We utilized a standardized (age and gender) mortality ratio (SMR) approach for comparison among the municipalities.

Results
In 2018, a total of 29,938 migraine patients were identified out of 391,528 adult HMO members, with an overall prevalence (per 10,000) of migraine of 764.64 (7.65%), 1143.34 (11.43%) for women, and 374.97 (3.75%) for men. Among the municipalities, adjusted prevalence (per 10,000) ranged from 386.15 (3.86%) to 1320.60 (13.21%). The female-to-male ratio ranged from 1.8:1 to 5.1:1. Prevalence rates were positively associated with the socioeconomic status of the municipalities (Spearman rho = 0.472, P = 0.031).

Conclusions
High variability in the prevalence of diagnosed migraine suggests underdiagnosis. Resources for awareness and educational programs should be directed to low diagnosed prevalence communities.

Graphical Abstract
Sleep, physical activity, and sedentary behaviors as factors related to depression and health-related quality of life among older women living alone: a population-based study
Authors: Jang Soyoung , Yang Eunjin 
Published: March 2023

Abstract
Background
Although the number of older women living alone (OWLA) has risen steadily in aging societies, and research has been conducted on depression and health-related quality of life (HRQoL) among older adults, research is scarce on the health behaviors of OWLA, including their sleep, physical activity, and sedentary behaviors. Hence, we aimed to identify factors related to depression and HRQoL among this subset of the population, focusing on their health behaviors, using Andersen’s model as a research framework.

Methods
Data for secondary analysis were from the Korean National Health and Nutritional Examination Survey (2014, 2016, 2018, and 2020). The inclusion criteria were (1) women aged 65 and older and (2) those living alone. We included 794 older South Korean women living alone from 31,051 respondents. We used hierarchical regression analysis, considering sampling weight and a complex sample design, to identify factors related to depression and HRQoL.

Results
Among the health behavior factors of Andersen’s model as a research framework, sleep was associated with depression, whereas physical activity and sedentary behaviors were related to HRQoL. Subjective health status, limited activity, and perceived stress were associated with both depression and HRQoL. Household income, as an enabling factor, was only associated with HRQoL. The final regression model explained 39% of the variance in depression (p < 0.001) and 37% of the variance in HRQoL (p < 0.001).

Conclusions
Our study highlights the importance of strategies to improve specific healthy behaviors that affect depression and HRQoL in OWLA. Appropriate interventions that target increasing physical activity and quality of sleep, and decreasing sedentary behaviors, will be effective to enhance the well-being of OWLA. Healthcare providers should comprehensively understand the characteristics of OWLA and pay more attention to enabling, need, and health behavior factors.
Synthesis and luminescence properties of Mn-doped Cs2KBiCl6 double perovskite phosphors
Authors: Zhong Qinghua , Yu Shuai , Zheng Quanwei , Zhang Leilei , Zhang Xiaowen 
Published: March 2023

AbstractNovel lead-free double perovskite phosphors of Mn-doped Cs2KBiCl6 (Cs2KBiCl6:Mn2+) have been facilely synthesized by using typical hydrothermal method. X-ray diffraction, scanning electron microscope, X-ray photoelectron spectroscopy, electron paramagnetic resonance, and photoluminescence measurements confirm that the synthesized Cs2KBiCl6:Mn2+ phosphors behave double perovskite structure, good morphology, excellent stability, and superior optical properties. An optimal doping concentration of Mn/Bi = 0.4 is achieved in Cs2KBiCl6:Mn2+ phosphors, showing maximum photoluminescence quantum yield of 87.2%, lifetime of 0.98 ms, and orange-red fluorescence with the emission peak at 595 nm under UV light excitation. The probable luminescence mechanism could be ascribed to excitation energy transferring from Cs2KBiCl6 to Mn, and accordingly contributing to the 4T1–6A1 transition of the Mn d electron. Superb optical properties provide much room for in-depth fluorescence researches and potential applications of Cs2KBiCl6:Mn2+ phosphors.
Shattering and yield expression of sesame (Sesamum indicum L) genotypes influenced by paclobutrazol concentration under rainfed conditions of Pothwar
Authors: Ahmed Jahangir , Qadir Ghulam , Ansar Muhammad , Wattoo Fahad Masoud , Javed Talha , Ali Baber , Marc Romina Alina , Rahimi Mehdi 
Published: March 2023

AbstractSeed shattering is a critical challenge that significantly reduces sesame production by 50%. These shattering losses can be reduced by selecting shattering resistant genotypes or by incorporating modern agronomic management such as paclobutrazol, which can boost productivity and prevent seed shattering in sesame. Two-years of field trials were conducted to examine the effect of sesame genotypes, environment, and paclobutrazol (PBZ) concentrations. Twelve sesame genotypes were used in a four-way factorial RCBD with three replications and five PBZ concentrations (T0 = Control; T1 = 150; T2 = 300; T3 = 450; and T4 = 600 mg L− 1) under rainfed conditions of Pothwar. The findings revealed significant variations in the major effects of all examined variables (genotypes, locations, years, and PBZ levels). Sesame genotypes PI-154304 and PI-175907 had the highest plant height, number of capsule plant− 1, seed capsule− 1, 1000 seed weight, biological yield, and seed yield, while also having the lowest seed losses and shattering percentage. Regarding environments, NARC-Islamabad generated the highest plant height, number of capsule plant− 1, shattering percentage, and biological yield; however, the URF-Koont produced the highest seed yield with the lowest shattering percentage. Additionally, plant height, capsules plant− 1, and biological yield were higher in 2021, while seed capsule− 1, 1000 seed weight, seed losses, shattering percentage, and seed yield were higher in 2020. PBZ concentration affected all measured parameters; plant height and number of seed capsule− 1 decreased with increasing PBZ concentrations. 450 mg L− 1 PBZ concentration generated the highest biomass, number of capsules plant− 1, and seed yield. At the same time, PBZ concentration 600 mg L− 1 generated the smallest plant, the lowest seed capsules− 1, the greatest thousand seed weight, and the lowest shattering percentage. The study concluded that paclobutrazol could dramatically reduce shattering percentage and shattering losses while increasing economic returns through better productivity. Based on the findings, the genotypes PI-154304 and PI-175907 with paclobutrazol level 450 mgL− 1 may be suggested for cultivation in Pothwar farming community under rainfed conditions, as they showed promising shattering resistance as well as enhanced growth and yield.
Correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery
Authors: Liu Qing , Li Liheng , Wei Jingwen , Xie Yubo 
Published: March 2023

Abstract
Background
The correlation and influencing factors of preoperative anxiety, postoperative pain, and delirium in elderly patients undergoing gastrointestinal cancer surgery were explored with the Beck Anxiety Inventory (BAI) scale, 10-point Visual Analogue Scale (VAS), and Confusion Assessment Method Chinese Reversion (CAM-CR) scale.

Methods
A total of 120 patients aged 65 years old who receiving gastrointestinal cancer surgery were enrolled in the study. Perioperative anxiety, pain, and delirium were assessed by the BAI scale, VAS scale, and CAM-CR scale, respectively. The correlation and influencing factors of preoperative high anxiety, postoperative high pain, and postoperative delirium were analyzed.

Results
Preoperative high anxiety had a moderate positive correlation with postoperative high pain (P < 0.001, r = 0.410), and had a weak positive correlation with postoperative delirium (P = 0.005, r = 0.281). postoperative high pain had a weak positive correlation with postoperative delirium (P = 0.017, r = 0.236). Type of cancer and surgical approach were considered to be independent risk factors of preoperative high anxiety (P = 0.006 and P = 0.021). Preoperative high anxiety was considered to be an independent risk factor of postoperative high pain (P< 0.001). Age and preoperative high anxiety were considered to be independent risk factors of postoperative delirium (P< 0.001 and P = 0.010).

Conclusions
Elderly patients undergoing gastrointestinal cancer surgery had a higher incidence of preoperative anxiety, as well as first-day postoperative pain and first-day postoperative delirium. Factors such as type of cancer, surgical approach and preoperative anxiety had been identified as influencing preoperative anxiety levels; preoperative anxiety had been linked to postoperative pain; and age and preoperative anxiety have been identified as influencing factors of postoperative delirium.

Trial registration
hiCTR2000032008, 17/04/2020, Title: “Effects of different analgesic methods on postoperative recovery of elderly patients with digestive tract tumor”. Website: https://www.chictr.ogr.cn.
Fragment length profiles of cancer mutations enhance detection of circulating tumor DNA in patients with early-stage hepatocellular carcinoma
Authors: Nguyen Van-Chu , Nguyen Trong Hieu , Phan Thanh Hai , Tran Thanh-Huong Thi , Pham Thu Thuy Thi , Ho Tan Dat , Nguyen Hue Hanh Thi , Duong Minh-Long , Nguyen Cao Minh , Nguyen Que-Tran Bui , Bach Hoai-Phuong Thi , Kim Van-Vu , Pham The-Anh , Nguyen Bao Toan , Nguyen Thanh Nhan Vo , Huynh Le Anh Khoa , Tran Vu Uyen , Tran Thuy Thi Thu , Nguyen Thanh Dang , Phu Dung Thai Bieu , Phan Boi Hoan Huu , Nguyen Quynh-Tho Thi , Truong Dinh-Kiet , Do Thanh-Thuy Thi , Nguyen Hoai-Nghia , Phan Minh-Duy , Giang Hoa , Tran Le Son 
Published: March 2023

Abstract
Background
Late detection of hepatocellular carcinoma (HCC) results in an overall 5-year survival rate of less than 16%. Liquid biopsy (LB) assays based on detecting circulating tumor DNA (ctDNA) might provide an opportunity to detect HCC early noninvasively. Increasing evidence indicates that ctDNA detection using mutation-based assays is significantly challenged by the abundance of white blood cell-derived mutations, non-tumor tissue-derived somatic mutations in plasma, and the mutational tumor heterogeneity.

Methods
Here, we employed concurrent analysis of cancer-related mutations, and their fragment length profiles to differentiate mutations from different sources. To distinguish persons with HCC (PwHCC) from healthy participants, we built a classification model using three fragmentomic features of ctDNA through deep sequencing of thirteen genes associated with HCC.

Results
Our model achieved an area under the curve (AUC) of 0.88, a sensitivity of 89%, and a specificity of 82% in the discovery cohort consisting of 55 PwHCC and 55 healthy participants. In an independent validation cohort of 54 PwHCC and 53 healthy participants, the established model achieved comparable classification performance with an AUC of 0.86 and yielded a sensitivity and specificity of 81%.

Conclusions
Our study provides a rationale for subsequent clinical evaluation of our assay performance in a large-scale prospective study.