bluuebunny/crossref_metadata_2025_split huggingface dataset:
A revitalized biopsychosocial model: core theory, research paradigms, and clinical implications
Authors: Bolton Derek 
Published: September 2023

AbstractThe biopsychosocial model (BPSM) was proposed by George Engel in 1977 as an improvement to the biomedical model (BMM), to take account of psychological and social as well as biological factors relevant to health and disease. Since then the BPSM has had a mixed reputation, as the overarching framework for psychiatry, perhaps for medicine generally, while also being criticized for being theoretically and empirically vacuous. Over the past few decades, substantial evidence has accumulated supporting the BPSM but its theory remains less clear. The first part of this paper reviews recent well-known, general theories in the relevant sciences that can provide a theoretical framework of the model, constituting a revitalized BPSM capable of theorizing causal interactions within and between biological, psychological, and social domains. Fundamental concepts in this new framework include causation as regulation and dysfunction as dysregulation. Associated research paradigms are outlined in Part 2. Research in psychological therapies and social epidemiology are major examples of programs that have produced results anomalous for the BMM and consistent with the BPSM. Theorized models of causal mechanisms enrich empirical data and two biopsychosocial examples are models of chronic stress and pain perception. Clinical implications are reviewed in Part 3. The BPSM accommodates psychological and social as well as biological treatment effects evident in the clinical trials literature. Personal, interpersonal, and institutional aspects of clinical care are out of the scope of the BMM, assigned to the art of healthcare rather than the science, but can be accommodated and theorized in the BPSM.
Decrease of left ventricular function measured by speckle-tracking echocardiography based on systemic lupus erythematosus severity in children
Authors: Rustam Masita I. , Ghrahani Reni , Hakim Dzulfikar D.L. , Kuswiyanto Rahmat B. , Dewi Mia M. , Rahayuningsih Sri E. 
Published: September 2023

AbstractIntroduction:Systemic lupus erythematosus in children generally manifests more severely with a more aggressive disease course. Cardiac involvement in systemic lupus erythematosus often does not show specific signs and symptoms, but speckle-tracking echocardiography can detect cardiac dysfunction. This study aimed to determine the differences in left ventricular function as measured by speckle-tracking echocardiography in children with various severity of systemic lupus erythematosus activity.Methods:A cross-sectional study of 49 children diagnosed with systemic lupus erythematosus are currently undergoing outpatient or inpatient care at Dr Hasan Sadikin General Hospital, Bandung, from May 2023 to June 2023. Disease activity was assessed by Mexican Version of the Systemic Lupus Erythematosus Disease Activity Index (MEX-SLEDAI) with a score of 2–5 classified as mild activity, 6–9 as moderate, and ≥10 as severe. Each subject underwent conventional echocardiography and speckle-tracking echocardiography with a Philips EPIQ machine performed by a Pediatric Cardiologist Consultant 10 days after inclusion.Results:Fifteen (30.6%) subjects had mild disease activity, and 34 (69.4%) subjects had moderate disease activity. Most subjects (81.96%) were female with an average age of 15 years. The mean ejection fraction and fractional shortening as well as the median E/A ratio in the mild and moderate disease activity groups were not significantly different (65.76 versus 67.38%, 35.73 versus 37.11%, 1.6 versus 1.5%, respectively, p > 0.005). The global longitudinal strain in the moderate activity group was reduced more significantly than in the mild activity group (−16.58 versus −19.65, p = 0.008).Conclusion:Left ventricular function as measured by speckle-tracking echocardiography was lower in children with moderate systemic lupus erythematosus activity than those with mild disease activity.
Utility of a pharmacist-managed Anticoagulation Program in patients with congenital heart disease
Authors: O’Neil Meredith J. , Garr BreAnn N. , Faircloth Jenna M. , Ciambarella Julie A. , Lubert Adam M. , Nelson Nicole L. , Cooper David S. 
Published: September 2023

AbstractBackground:Warfarin remains the preferred anticoagulant for many patients with CHD. The complexity of management led our centre to shift from a nurse-physician-managed model with many providers to a pharmacist-managed model with a centralized anticoagulation team. We aim to describe the patient cohort managed by our Anticoagulation Program and evaluate the impact of implementation of this consistent, pharmacist-managed model on time in therapeutic range, an evidence-based marker for clinical outcomes.Methods:A single-centre retrospective cohort study was conducted to evaluate the impact of the transition to a pharmacist-managed model to improve anticoagulation management at a tertiary pediatric heart centre. The percent time in therapeutic range for a cohort managed by both models was compared using a paired t-test. Patient characteristics and time in therapeutic range of the program were also described.Results:After implementing the pharmacist-managed model, the time in therapeutic range for a cohort of 58 patients increased from 65.7 to 80.2% (p < .001), and our Anticoagulation Program consistently maintained this improvement from 2013 to 2022. The cohort of patients managed by the Anticoagulation Program in 2022 included 119 patients with a median age of 24 years (range 19 months–69 years) with the most common indication for warfarin being mechanical valve replacement (n = 81, 68%).Conclusions:Through a practice change incorporating a collaborative, centralized, pharmacist-managed model, this cohort of CHD patients on warfarin had a fifteen percent increase in time in therapeutic range, which was sustained for nine years.
Rights, Abstraction, and Correlativity
Authors: Jonker Julian David 
Published: September 2023

AbstractI survey several counterexamples (by Raz and MacCormick) to Hohfeld's conjecture that a claim-right is correlative to a directed duty and (by Cornell and Frick) to Bentham's suggestion that a claim-right is correlative to a wronging. We can vindicate these claims of correlativity if we acknowledge that entitlements like claim-rights and directed duties admit of degrees of abstraction: that they may be general rather than specific, unspecified rather than specified, or indefinite rather than definite. I provide an error theory consisting in linguistic and practical reasons for why we articulate normative incidents in ways that threaten correlativity. And I deny that abstraction imposes a heavy metaphysical cost on rights theory, though I leave open whether abstraction excludes certain explanatory accounts of rights such as the interest theory or will theory.
Why Monarchy Should Be Abolished
Authors: Kyriacou Christos 
Published: September 2023

AbstractMonarchy is a form of government that, roughly, dictates that the right to rule is inherited by birth by a single ruler. But monarchy (absolute or constitutional) breaches fundamental moral principles that undergird representative democracy, such as basic moral equality, dignity and desert. Simply put, the monarchs (and their family) are treated as morally superior to ordinary citizens and as a result ordinary citizens are treated in an unfair and undignified manner. For example, monarchs are respected, enjoy dignity, income, opportunity, public office and exalted social status just because of their inherited office, which is due to the mere historical accident of family lineage. Hence, we have good moral reason to abolish monarchy. Finally, I briefly reply to the pragmatic argument for constitutional monarchy, namely, the argument that monarchy can be allowed to play a largely ceremonial role in the context of democracy because it is beneficial for the function of society. As I argue, societies run by presidential democracies can function equally well and, what is more, no matter what the pragmatic reasons for constitutional monarchy are, we still have stronger moral reasons against it. Therefore, it should be abolished.
Jordan Peterson's Confusion over Religious Symbolism: A Lesson from Cain and Abel
Authors: Nickel Ken 
Published: September 2023

AbstractJordan Peterson is a darling among conservatives and religious people alike. In defending religious belief as the only bulwark against a return to the dark ages, it becomes obvious that Peterson himself doesn't believe in what he preaches. People, he insists, should believe in the archetypal symbolism that is only revealed through a close reading of the Bible. If atheists would only read scripture with more sophistication they wouldn't so embarrassingly reject religion, and simultaneously threaten the very foundations of Western Civilization. It turns out that it's Peterson who comprehensively ignores symbolism. A simple Sunday school lesson shows this.
Introducing Derrida
Authors: Salmon Peter 
Published: September 2023

AbstractJacques Derrida is one of the most controversial philosophers of the twentieth century, who is hailed by his followers as a genius, derided by his detractors as a charlatan. His work continues to be a source of often inordinate praise and blame. How does Derrida provoke such violent reactions? What is ‘deconstruction’, his most famous technique? And is there something in his work that can be useful to even the most hostile of his critics?
Selection of inbreds with better combining ability is instrumental in developing CMS-based heterotic hybrids in tropical carrot (Daucus carota L.)
Authors: Janani R. , Sureja Amish K. , Dey Shyam S. , Krishnan S. Gopala , Bhardwaj Rakesh , Rudra Shalini G. , Tomar Bhoopal S. 
Published: September 2023

AbstractCarrot is an important vegetable crop worldwide valued for its fleshy edible roots of varied colours. Owing to its highly cross-pollinated nature and small flower size, cytoplasmic male sterility (CMS) is being utilized for hybrid development. Among different types of male sterility, petaloid CMS is widely used for hybrid carrot breeding globally. This study aimed to develop selection criteria for parents in developing heterotic F1 hybrids using CMS lines. A large number of agro-morphological traits and Simple Sequence Repeats (genomic-SSRs) were used to assess the diversity among parental lines. We developed 60 F1 hybrids by crossing four petaloid CMS lines and 15 testers in line × tester mating design and evaluated them in replicated randomized block design trial for four vegetative and 11 economic traits. The mean squares of all the traits in line × tester interactions were significant. The estimates of genetic components of variance indicated predominance of non-additive gene action except for root maturity, root length and core diameter. The hybrids with highest per se performance also had significant positive specific combining ability effects. The root yield and root weight showed highest heterosis percentage (33%). The best performing heterotic hybrids were DCatH-5392, DCatH-700 and DCatH-9892. Correlation between genetic distance and relative heterosis of economic traits indicated no significant association and thus genetic distance could not be used to predict heterosis. As most of the yield-related traits were controlled by non-additive gene action, heterosis breeding could be potentially used along with combining ability analysis to reduce time in selection of best parents and crosses in tropical carrot.
A pilot study to examine the association between COX-2 rs5275 polymorphism and the response to repetitive transcranial stimulation in schizophrenia
Authors: Wang Pingping , Guan Xiaoni , Su Xiuru , Wu Fengchun , Xiu Meihong 
Published: September 2023

AbstractHigh frequency (HF)-rTMS has been shown to improve cognitive functions in patients with schizophrenia (SCZ). This study aimed to investigate whether COX-2 rs5275 variants were associated with cognitive improvements following rTMS treatment in patients with SCZ. Forty-eight hospitalized patients with SCZ were assigned to the neuronavigation HF-rTMS group and 28 patients to the sham group over left DLPFC for 1 month. Cognitive function was evaluated using the repeatable battery for the assessment of neuropsychological status (RBANS) at weeks 0 and 4. COX-2 rs5275 polymorphism was genotyped by a technician. At baseline, C allele carriers showed better cognitive performance relative to patients with TT homozygote. Additionally, C allele carriers had greater improvement in memory from the follow-up to baseline following rTMS stimulation, while patients with the TT genotype showed no significant improvement in memory index. More importantly, we found that COX-2 rs5275 was correlated with the response to rTMS after controlling for the covariates. This study data indicate that COX-2 rs5275 was associated with improvements in immediate memory after HF-rTMS treatment in patients with SCZ. rTMS shows an effect on memory only in C allele carriers, but not in those with the TT genotype.
Geo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria
Authors: Pradhan Sayantan , Hore Samrat , Roy Stabak , Manna Simi , Dam Paulami , Mondal Rittick , Ghati Amit , Biswas Trishanjan , Shaw Subhajit , Sharma Supriya , Singh Waikhom Somraj , Maji Suman Kumar , Roy Sankarsan , Basu Aparajita , Pandey Kailash C. , Samanta Soumadri , Vashisht Kapil , Dolai Tuphan Kanti , Kundu Pratip Kumar , Mitra Saptarshi , Biswas Debasish , Sadat Abdul , Shokriyan Masuma , Maity Amit Bikram , Mandal Amit Kumar , İnce İkbal Agah 
Published: September 2023

AbstractMalaria prevalence has become medically important and a socioeconomic impediment for the endemic regions, including Purulia, West Bengal. Geo-environmental variables, humidity, altitude, and land use patterns are responsible for malaria. For surveillance of the endemic nature of Purulia’s blocks, statistical and spatiotemporal factors analysis have been done here. Also, a novel approach for the Pf malaria treatment using methanolic leaf extract of Morus alba S1 has significantly reduced the parasite load. The EC50 value (1.852) of the methanolic extract of M. alba S1 with P. falciparum 3D7 strain is close to the EC50 value (0.998) of the standard drug chloroquine with the same chloroquine-sensitive strain. Further studies with an in-silico model have shown successful interaction between DHFR and the phytochemicals. Both 1-octadecyne and oxirane interacted favourably, which was depicted through GC–MS analysis. The predicted binary logistic regression model will help the policy makers for epidemiological surveillance in malaria-prone areas worldwide when substantial climate variables create a circumstance favourable for malaria. From the in vitro and in silico studies, it can be concluded that the methanolic extract of M. alba S1 leaves were proven to have promising antiplasmodial activity. Thus, there is a scope for policy-driven approach for discovering and developing these lead compounds and undermining the rising resistance to the frontline anti-malarial drugs in the world.
Maternal body mass index is not associated with assisted reproductive technology outcomes
Authors: Kidera Nobuyuki , Ishikawa Tomonori , Kawamura Toshihiro , Miyasaka Naoyuki 
Published: September 2023

AbstractThe effects of body mass index (BMI) on assisted reproductive technology (ART) outcomes such as ovarian dysfunction, poor ovum quality, and endometrial dysfunction have been studied; however, many aspects remain controversial. Therefore, we retrospectively investigated the relationship between BMI and ART outcomes. For 14,605 oocyte retrieval cycles at our hospital between January 2016 and December 2020, BMI was divided into five groups (< 18.5, 18.5–20.0, 20.0–22.5, 22.5–25.0, ≥ 25 kg/m2) and measured before oocyte retrieval. The normal fertilization and high-grade blastocyst rates were compared. In addition, in the 7,122 frozen-thawed embryo transfers (FET) with highest-grade embryos, the clinical pregnancy, miscarriage, and live birth rates were investigated in the five BMI groups. Multiple regression analysis on normal fertilization and high-grade blastocyst rates revealed no statistically significant differences. Furthermore, after propensity score matching on FET, there was no significant difference in clinical pregnancy, miscarriage, and live birth rates in the BMI groups. BMI is a risk factor for complications during pregnancy; however, it does not affect ART outcomes. Therefore, we believe weight guidance should be provided to women with obesity at the start of infertility treatment, but treatment should not be delayed.
Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy
Authors: Drago Gaspare , Ruggieri Silvia , Sprovieri Mario , Rizzo Giulia , Colombo Paolo , Giosuè Cristina , Quinci Enza , Traina Anna , Gastaldelli Amalia , Cibella Fabio , Panunzi Simona 
Published: September 2023

AbstractProtecting the health of pregnant women from environmental stressors is crucial for reducing the burden of non-communicable diseases. In industrially contaminated sites, this action is particularly challenging due to the heterogeneous pollutant mixtures in environmental matrices. The aim of this study was to evaluate distribution patterns of mercury, hexachlorobenzene and polychlorobiphenyls in the serum of 161 pregnant women recruited in the framework of the Neonatal Environment and Health Outcomes (NEHO) cohort and living both inside and outside the National Priority Contaminated Site (NPCS) of Priolo. Food macro-categories were determined, and serum levels of contaminants were used to perform k-means cluster analysis and identify the role of food in pollutant transfer from the environment. Two groups of mothers with high and low measured pollutant levels were distinguished. Concentrations in mothers in the high-exposure cluster were at least twofold for all the evaluated pollutants (p < 0.0001) and included mothers living inside and outside NPCS, with a predominance of individuals from the NPCS (p = 0.045). Fish consumption was higher in the high-exposure cluster (p = 0.019). These findings suggest a link between contamination of environmental matrices such as sediment with maternal exposure, through the intake of local food. Such consideration appears poorly investigated in the context of contaminated sites.
Analysis of cnidarian Gcm suggests a neuronal origin of glial EAAT1 function
Authors: Sheloukhova Larisa , Watanabe Hiroshi 
Published: September 2023

AbstractIn bilaterian central nervous systems, coordination of neurotransmission by glial cells enables highly sophisticated neural functions. The diversity of transcription factors (TFs) involved in gliogenesis suggests multiple evolutionary origins of various glial cell types of bilaterians. Many of these TFs including the glial cells missing (Gcm) are also present in genomes of Cnidaria, the closest outgroup to Bilateria, but their function remains to be elucidated. In this study, we analyzed the function of Gcm, a multifunctional TF involved in development of glial and non-glial cell types, in the sea anemone, Nematostella vectensis. siRNA-mediated knockdown of Nematostella Gcm altered expression of cell adhesion proteins, glutamate and GABA transporters, ion channels, metabolic enzymes, and zinc finger and Ets-related TFs. NvGcm and mRNAs of downstream genes are expressed in broad neural cell clusters. However, immunostaining of a NvGcm target protein, the glutamate transporter, NvEAAT1, visualized a novel class of cells with flat cell bodies and no clear processes. Together with the finding of unique morphological features of NvEAAT1-functioning cells, these data suggest that extracellular glutamate metabolism, one of major glial functions, is deployed downstream of Gcm in specific neural cell types in Cnidaria.
Future changes in atmospheric synoptic variability slow down ocean circulation and decrease primary productivity in the tropical Pacific Ocean
Authors: Duteil Olaf , Park Wonsun 
Published: September 2023

AbstractThis study investigates the impact of future changes in atmospheric synoptic variability (ASV) on ocean properties and biogeochemical cycles in the tropical Pacific Ocean using coupled and forced atmosphere–ocean model experiments. Future climate projections show an annual mean decrease in ASV in subtropical gyres and an increase in the tropical band. Maintaining ASV to current values lead to a deepening of the mixed layer in subtropical regions and a shalllowing at the equator associated with a sea surface temperature decrease. The changes in ASV impact the large-scale ocean circulation and the strength of the subtropical and tropical cells, which constrain the equatorial water upwelling and the tropical net primary productivity. Ultimately, this study highlights the significance of ASV in understanding the impacts of climate change on ocean dynamics and biogeochemical processes, as half of the primary productivity decline due to climate change is caused by changes of ASV in the tropical Pacific Ocean.
Structural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD nuclease sub-family
Authors: Shaibullah Sofiyah , Shuhaimi Nurshahirah , Ker De-Sheng , Mohd-Sharif Nurhikmah , Ho Kok Lian , Teh Aik-Hong , Waterman Jitka , Tang Thean-Hock , Wong Rui-Rui , Nathan Sheila , Mohamed Rahmah , Ng Min Jia , Fung Shin-Yee , Jonet Mohd Anuar , Firdaus-Raih Mohd , Ng Chyan Leong 
Published: September 2023

AbstractBurkholderia pseudomallei is a highly versatile pathogen with ~25% of its genome annotated to encode hypothetical proteins. One such hypothetical protein, BPSL1038, is conserved across seven bacterial genera and 654 Burkholderia spp. Here, we present a 1.55 Å resolution crystal structure of BPSL1038. The overall structure folded into a modified βαββαβα ferredoxin fold similar to known Cas2 nucleases. The Cas2 equivalent catalytic aspartate (D11) pairs are conserved in BPSL1038 although B. pseudomallei has no known CRISPR associated system. Functional analysis revealed that BPSL1038 is a nuclease with endonuclease activity towards double-stranded DNA. The DNase activity is divalent ion independent and optimum at pH 6. The concentration of monovalent ions (Na+ and K+) is crucial for nuclease activity. An active site with a unique D11(X20)SST motif was identified and proposed for BPSL1038 and its orthologs. Structure modelling indicates the catalytic role of the D11(X20)SST motif and that the arginine residues R10 and R30 may interact with the nucleic acid backbone. The structural similarity of BPSL1038 to Cas2 proteins suggests that BPSL1038 may represent a sub-family of nucleases that share a common ancestor with Cas2.
Dossier « Recherches sur la question animale : entre mobilisations sociétales et innovations technologiques » – La résistible ascension de l’éthique ? Sciences sociales et question animale
Authors: Michalon Jérôme 
Published: September 2023

L’objectif de cet article est d’analyser les rapports entre les sciences sociales et la montée en puissance de la cause animale. Retraçant la manière dont l’objet « relations humains-animaux » s’est constitué dans les contextes anglo-américain et français, je défends l’idée que l’évolution générale de ces recherches participe de la montée du zoocentrisme. Plus spécifiquement, j’analyse la manière dont les théories antispécistes et l’éthique animale, très influentes dans le monde anglo-américain, ont été reçues en France. Les critiques formulées à leur encontre par les universitaires en sciences sociales sont particulièrement étudiées. Je montre comment ces critiques contribuent – paradoxalement – à constituer l’éthique animale en point de passage obligé pour toute réflexion académique sur les rapports aux animaux, en lui offrant un nouvel espace éditorial, celui des sciences sociales.