bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristic analysis of adverse reactions of five anti-TNFɑ agents: a descriptive analysis from WHO-VigiAccess
Authors: Li Mingming , You Ruxu , Su Yuyong , Zhou Hongbo , Gong Shiwei 
Published: July 2023

Introduction: Tumor necrosis factor (TNF) inhibitors (adalimumab, infliximab, etanercept, golimumab, and certolizumab pegol) have revolutionized the treatment of severe immune-mediated inflammatory diseases, including rheumatoid arthritis, Crohn’s disease, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. This study assessed adverse drug reactions (ADRs) after the use of TNFα inhibitors in VigiAccess of the World Health Organization (WHO) and compared the adverse reaction characteristics of five inhibitors to select the drug with the least risk for individualized patient use.Methods: The study was a retrospective descriptive analysis method in design. We sorted out five marketed anti-TNFα drugs, and their ADR reports were obtained from WHO-VigiAccess. Data collection included data on the age groups, sex, and regions of patients worldwide covered by ADR reports, as well as data on disease systems and symptoms caused by ADRs recorded in annual ADR reports and reports received by the WHO. By calculating the proportion of adverse reactions reported for each drug, we compared the similarities and differences in adverse reactions for the five drugs.Results: Overall, 1,403,273 adverse events (AEs) related to the five anti-TNFα agents had been reported in VigiAccess at the time of the search. The results show that the 10 most commonly reported AE manifestations were rash, arthralgia, rheumatoid arthritis, headache, pneumonia, psoriasis, nausea, diarrhea, pruritus, and dyspnea. The top five commonly reported AE types of anti-TNFα drugs were as follows: infections and infestations (184,909, 23.0%), musculoskeletal and connective tissue disorders (704,657, 28.6%), gastrointestinal disorders (122,373, 15.3%), skin and subcutaneous tissue disorders (108,259, 13.5%), and nervous system disorders (88,498, 11.0%). The preferred terms of myelosuppression and acromegaly were obvious in golimumab. Infliximab showed a significantly higher ADR report ratio in the infusion-related reaction compared to the other four inhibitors. The rate of ADR reports for lower respiratory tract infection and other infections was the highest for golimumab.Conclusion: No causal associations could be established between the TNFα inhibitors and the ADRs. Current comparative observational studies of these inhibitors revealed common and specific adverse reactions in the ADR reports of the WHO received for these drugs. Clinicians should improve the rational use of these high-priced drugs according to the characteristics of ADRs.
Ultrasound-assisted intravesical botulinum toxin A delivery attenuates acetic acid—induced bladder hyperactivity in rats
Authors: Liu Qinggang , Gao Yi , Cong Huiling , Liao Limin 
Published: July 2023

Background: Intradetrusor injection of botulinum toxin A (BTX-A) is an effective treatment for overactive bladder (OAB). However, the occurrence of adverse events associated with BTX-A injection therapy hinders its acceptance among patients and its clinical promotion. Intravesical instillation of BTX-A offers a promising alternative to injection therapy for treating OAB. Nevertheless, due to the presence of the bladder permeability barrier (BPB) and the high molecular weight of BTX-A, direct instillation is unable to penetrate the bladder urothelium.Purpose: This study aims to investigate the safety and feasibility of ultrasound-assisted intravesical delivery of BTX-A and its potential benefits in a rat model of bladder hyperactivity induced by acetic acid instillation.Methods: Hengli BTX-A and microbubbles (MB) were mixed and prepared as a novel complex. The size distribution and zeta potentials of the complex were measured. On day 1, rats’ bladders were instilled with 1 mL of saline, BTX-A (20 U in 1 mL), MB, or MB-BTX-A (20 U in 1 mL) complex with or without ultrasound (US) exposure (1 MHz, 1.5 W/cm2, 50% duty cycle, sonication for 10 s with a 10-s pause for a total of 10 min). The instillations were maintained for 30 min. After 7 days, cystometry was performed by filling the bladder with saline and 0.3% acetic acid (AA). Bladders were collected, weighed, and processed for immunoblotting, enzyme-linked immunosorbent assay (ELISA), histologic, and immunofluorescence analyses. Expression and distribution of SNAP-25 and SNAP-23 were assessed using Western blot and immunofluorescence. Calcitonin gene-related peptide (CGRP) in the bladder was detected using ELISA.Results: Intercontraction intervals (ICI) decreased by 72.99%, 76.16%, and 73.96% in rats pretreated with saline, BTX-A, and US + MB, respectively. However, rats treated with US + MB + BTX-A showed a significantly reduced response to AA instillation (57.31% decrease in ICI) without affecting amplitude, baseline pressure, or threshold pressure. Rats treated with US + MB + BTX-A exhibited increased cleavage of SNAP-25 and CGRP expression compared to the control group.Conclusion: Ultrasound-assisted intravesical delivery of BTX-A, with the assistance of MB cavitation, led to cleavage of SNAP-25, inhibition of calcitonin gene-related peptide release from afferent nerve terminals, and amelioration of acetic acid-induced bladder hyperactivity. These results support ultrasound-assisted intravesical delivery as an efficient non-injection method for administering BTX-A.
Effects of acne severity and acne-related quality of life on depressive symptoms among adolescents and young adults: a cross-sectional study in Bangladesh
Authors: Tasneem Takfi , Begum Afroza , Chowdhury Mohammad Rocky Khan , Rahman Syed , Macassa Gloria , Manzoor Jasmin , Rashid Mamunur 
Published: July 2023

IntroductionDepression is a common mental health disorder and one of the major causes of disability. This study aimed at investigating the relationship of acne severity and acne-related quality of life with depressive symptoms, and the mediating effect of acne-related quality of life in a relationship between acne severity and depressive symptoms.MethodsThis is a cross-sectional study. Data were collected from acne patients attending a tertiary-level hospital, using a questionnaire that comprised three validated instruments – Investigator’s Global Assessment (a single item) scale, Cardiff Acne Disability Index, and Beck Depression Inventory for measuring acne severity, acne-related quality of life, and depressive symptoms, respectively. Logistic regression and linear regression were used to examine the association between acne severity and depressive symptoms and a correlation between the acne-related quality of life and depressive symptoms, respectively. A mediation analysis was also performed to see the mediation effects of acne-related quality of life in a relationship between acne severity and depressive symptoms.ResultsA total of 185 acne patients (155 females, 83.8%) with a mean age was 22.55 ± 8.67 years were included in the study. Adolescents and young adults with severe and moderate acne had 6.14-and 2.28 times higher odds of depression compared to their peers with mild acne, respectively. Patients with low levels of acne-related quality of life had a higher level of depressive symptoms (β = 0.42, p &lt; 0.001). The total effect (direct + indirect) was also significant (β = 0.27, 95% CI: 1.29–4.09), implying the effect of acne severity on depression.ConclusionThe present study suggests that acne severity and acne-related quality of life were associated with depressive symptoms among patients with acne vulgaris. The study also indicates that the relationship between acne severity and depressive symptoms might occur through a chain-mediating effect of acne disability in this population.
Characteristics of Sluggish Cognitive Tempo among adults with ADHD: objective neurocognitive measures align with self-report of executive function
Authors: Krone Beth , Adler Lenard A. , Anbarasan Deepti , Leon Terry , Gallagher Richard , Patel Pooja , Faraone Stephen V. , Newcorn Jeffrey H. 
Published: July 2023

IntroductionSluggish Cognitive Tempo (SCT) is a syndrome characterized by cognitive hypo-arousal that often appears as daytime sleepiness or drowsiness, mental fogginess, being easily confused, having difficulty with holding and manipulating information in working memory, and being forgetful. Although it frequently co-travels with attention-deficit/hyperactivity disorder (ADHD) or other conditions and confers significantly greater impairment, there are few studies examining SCT among adults with ADHD. Understanding what features SCT confers in association with ADHD, distinct from other conditions associating with ADHD, is critically important to confirm if SCT is a distinct syndrome that requires special assessment methods and special, distinct treatment efforts to reduce its impact. This study describes the clinical and neuropsychological features of SCT in a sample of adults with well-defined ADHD, and examines the relationship of SCT with other measures of ADHD, neurocognition, executive function (EF), and impairment.MethodsA sample of n = 106 adults with ADHD, ages 18-57 years, was assessed for SCT using the Barkley SCT scale. Adults with (SCT+) and without (SCT-) SCT received a comprehensive clinical assessment battery, and neuropsychological testing. Clinical and neuropsychological variables were examined for their associations with SCT. The variables were treated with Principal Axis Factoring with Promax with Kaiser Normalization to elucidate latent constructs and determine performance profiles associated with SCT among people with ADHD.ResultsEF Deficits and emotional dyscontrol (ED) symptoms significantly differentiated adults with ADHD and SCT whether measured via self or clinician report. Additionally, significantly greater impairment via both clinician and participant report was seen in the SCT + versus SCT - cohorts. SCT was also associated with a significantly distinct profile on the neuropsychological battery, characterized by a pattern of slower latencies and cognitive strategy choices across CANTAB and WAIS subtests, that reveals difficulty with increased cognitive load, which primarily accounted for the higher level of impairment in the SCT group.DiscussionThe convergence of clinical ratings and neurocognitive measures of EF deficits is consistent with the conclusion that SCT represents a distinct subgroup of adults with ADHD.
SUKSESKAN “SEHAT NEGERIKU” PROGRAM BULAN IMUNISASI ANAK NASIONAL 2022 (BIAN) DI WILAYAH KELURAHAN MANGUNHARJO SEMARANG
Authors: Munafiah Durrotun , Mujahidah Sa'adah 
Published: July 2023

Kementerian Kesehatan mencanangkan Bulan Imunisasi Anak Nasional (BIAN) 2022, Kegiatan ini dilakukan untuk meningkatkan kesadaran dan pemahaman kepada seluruh masyarakat akan pentingnya pelaksanaan Bulan Imunisasi Anak Nasional mempertahankan Indonesia Bebas Polio dan mewujudkan Dunia Bebas Polio pada tahun 2026 serta mencegah terjadinya Kejadian Luar Biasa PD3I lainnya. Universitas Karya Husada Semarang salah satu Universitas yang memiliki Fakultas Ilmu Keperawatan dan Kesehatan juga terlibat dalam mensukseskan program pemerintah BIAN 2022 tersebut dengan tridhama perguruan tinggi yaitu pengabdian kepada masyarakat dalam hal ini dosen khususnya yang praktik mandiri dan mahasiswa pada dan bekerjasama PKM Kedungmundu dan posyandu Harapan Sejahtera, kelurahan Mangunharjo. Kegiatan ini dengan harapannya, 100 % anak di Kota Semarang diimunisasi lengkap karena imunisasi merupakan langkah penting melindungi anak-anak dari berbagai penyakit pada usia tertentu sesuai jenis vaksin yang diberikan, sehingga anak anak akan sehat dan ceria. Kegiatan berjalan lancar sesuai dengan target pencapaian.Kata Kunci: anak; imunisasi; suksesTHE SUCCESS OF THE “HEALTHY COUNTRY” 2022 NATIONAL CHILDHOOD IMMUNIZATION MONTH (BIAN) PROGRAM IN THE MANGUNHARJO VILLAGE AREA, SEMARANGAbstract The Ministry of Health has launched the National Child Immunization Month (BIAN) 2022, this activity is carried out to increase awareness and understanding to the entire community of the importance of implementing the National Child Immunization Month to maintain Polio-Free Indonesia and realize a Polio-Free World in 2026 and prevent other PD3I Extraordinary Events. . Karya Husada University Semarang, one of the universities that has the Faculty of Nursing and Health Sciences is also involved in the success of the 2022 BIAN government program with the tridhama of higher education, namely community service, in this case lecturers, especially those who practice independently and students at and in collaboration with PKM Kedungmundu and Posyandu Harapan Sejahtera. , Mangunharjo village. It is hoped that 100% of children in Semarang City will be fully immunized because immunization is an important step to protect children from various diseases at a certain age according to the type of vaccine given, so that children will be healthy and happy. Activities run smoothly in accordance with the achievement targets. Keywords: : child; immunization; success
GERAKAN PENCEGAHAN MENUJU BEBAS HIPERTENSI PADA LANSIA DI KELURAHAN CELLU
Authors: Mandaty Fhandy Aldy , Agusman MM Fery , Megawati Megawati 
Published: July 2023

Hipertensi merupakan masalah kesehatan global pada lansia dengan angka kejadian yang tinggi. Umumnya penatalaksanaan lansia hipertensi hanya berorientasi pada metode farmakologi yaitu pemberian obat-obatan anti hipertensi. Tujuan pengabdian masyarakat ini yaitu mencegah kejadian hipertensi pada lansia. Pelaksanaan pengabdian masyarakat berupa pemberian pendidikan kesehatan tentang hipertensi dan pemeriksaan kesehatan. Kegiatan ini berientasi dengan menggunakan metode pendekatan pada lansia. Kegiatan ini juga didukung oleh peran aktif Kader Posyandu Lansia setempat dan petugas kesehatan dari Puskesmas Bajoe. Kegiatan dilakukan di Balai Pertemuan Puskesmas Bajoe pada tanggal 22 November 2022 dan diikuti oleh 30 lansia dengan variatif masalah kesehatan, dimana sebagian besar (60%) peserta kegiatan merupakan kategori lansia akhir. Pengukuran selama kegiatan ditemukan sebagian besar lansia memiliki IMT kategori normal dan gemuk (67,34%), memiliki pengetahuan cukup (43,33%) dan memiliki motivasi baik (63,33%). Rencana tindak lanjut dan evaluasi telah disampaikan kepada kader Posyandu Lansia dan Petugas Kesehatan dari Puskesmas Bajoe untuk melakukan controling terhadap status hipertensi lansia. Kata Kunci: hipertensi; lansia; pencegahanPREVENTION MOVEMENT TOWARDS FREE OF HYPERTENSION IN ELDERLY IN CELLU VILLAGEAbstract Hypertension is a global health problem in the elderly with a high incidence. Generally, the management of elderly hypertension is only oriented towards pharmacological methods such as give anti-hypertensive drugs. The purpose of this community service is to prevent the incidence of hypertension in the elderly. Implementation of community service in the form of providing health education about hypertension and health checks. This activity is oriented by using an approach to the elderly. This activity was also supported by the active role of the local Posyandu Cadres and health workers from the Bajoe Health Center. The activity was carried out at the Bajoe Health Center Meeting Hall on November 22 2022 and was attended by 30 elderly people with various health problems, where most (60%) of the activity participants were in the late elderly category. Measurements during the activity found that most of the elderly had normal and obese BMI categories (67.34%), had sufficient knowledge (43.33%) and had good motivation (63.33%). Follow-up and evaluation plans have been submitted to the cadres of the Elderly Posyandu and health workers from the Bajoe Health Center to control the hypertension status of the elderly. Keywords: elderly; hypertension; prevention
A Comparative Study of in Vitro Lipoxygenase Inhibition and DPPH (1, 1-Diphenyl-2-Picrylhydrazyl) Free Radical Scavenging Activity of Silybum marianum and [Notobasis syriaca (L.) Cass.] Fruits and Linum usitatisimum Seeds
Authors: Alshieka M. , Jandali R. , Agha Mohammad Isam Hasan 
Published: July 2023

Silybum marianum and Notobasis Syriaca belong to the most widespread thorny plants in the Middle East, the Mediterranean, and large areas of Asia. Both plants are derived from the Asteraceae family, while Flax seed (Linum usitatissmum L.) is belong to the family of Linaceae.
The aim of this study was to compare the scavenging activity of free radicals, and to evaluate the anti-inflammatory activity of the fruit in vitro compared with flax seed. Methanol and ethanol extracts were prepared and the activity of scavenging free radicals was studied using DPPH, and the anti-inflammatory activity was investigated in-vitro using soybean lipoxygenase, in comparison with quercetin and Lignin as standards.
The fruit extract from Notobasis Syriaca has the highest capacity to scavenge free radical DPPH (IC50=22.1 μg/ml), and it has higher ability to inhibit soybean lipoxygenase in-vitro (IC50= 2.7 μg/ml) than fruit extract from Silybum marianum (IC50= 9.8 μg/ml). This study showed that Silybum marianum and Notobasis Syriaca have a high ability to scavenge free radicals; and that both plants possess anti-inflammatory properties, while the scavenging potential of free radicals expressed in terms of IC50 (μg/ml) of flax seed showed extraction with a mixture of equal volumes of diethyl ether and ethyl acetate after direct acid hydrolysis exhibited higher antioxidant capacity (IC50=22.257±0.095 μg/ml). The median inhibitory concentration (IC50) was calculated according to the LOX enzyme inhibitory method. The IC50 value of a mixture of equal volumes of diethyl ether and ethyl acetate after direct acid hydrolysis extract of flaxseeds is 73.689±0.585 μg/ml.
As final conclusion it was found that flax seed extract has the highest anti-inflammatory activity.
Identification and Separation of the Degradation Products of Vildagliptin Tablets and Raw Material using LC-MS and NMR, and then Exploration of the Corresponding Degradation Pathways
Authors: Alqudah Enas , Abbadi Malak , Alqadoomi Sawsan , Abo Hameda Ibtihal , Arar Sharif , Sweidan Kamal 
Published: July 2023

A gradient high performance liquid chromatography (HPLC) method has been developed for the qualitative and quantitative analyses of vildagliptin related substances. This method is based on using of RP-C18 (250 × 4.6 mm×5µm) and gradient elution with phosphate buffer and methanol as mobile phase. Various forced degradation studies were conducted to establish an impurity profile for vildagliptin in the tablet formula. Three degradation products were produced upon exposing vildagliptin to different degradation conditions (acidic, basic, oxidative, photolytic, aqueous and thermal); their structures were characterized using LC-MS and NMR (1H NMR, 13C NMR and DEPT) techniques. Some excipient components, examined in this study, had major effect towards producing any extra new degradation products.
Cationic nitrogen-doped graphene coated silver as low-work function electrode for inverted perovskite solar cells
Authors: Yokoyama Kento , Lin Hao-Sheng , Shui Qing-Jun , Wang Xiaoyang , Saito Nagahiro , Matsuo Yutaka 
Published: July 2023

Abstract
Interfacial layers (ILs) located between the cathode and electron transport layer (ETL) in inverted perovskite solar cells are commonly required to achieve high-performance devices. Therefore, it is essential to develop excellent IL materials to improve efficiency and stability. This paper introduces the graphene-based IL material, namely cationic nitrogen-doped graphene (CNG), and evaluates its performance on a methylammonium lead iodide (MAPbI3)-type inverted perovskite solar cells. The device with a CNG IL achieved a power conversion efficiency of 13.5%, which is higher than a state-of-the-art reference using bathocuproine IL. Mechanistic studies demonstrated that the CNG IL can (1) efficiently collect electrons from the lowest unoccupied molecular orbital of ETL by lowering the work function of the silver cathode, (2) improve the conductivity of the silver electrode for better electron transfer, and (3) smooth out the interface contact between ETL and cathode to reduce defects in the device. As a result, the CNG IL enhanced the inverted perovskite solar cells performance by simultaneously increasing the open-circuit voltage, short-circuit current density, and fill factor. Moreover, the unencapsulated CNG IL-applied device demonstrated good long-term stability, with 96% efficiency retained over 1000 h in nitrogen atmosphere at room temperature.
Multi-active region AlGaN UV LEDs with transparent tunnel junctions
Authors: Dominic Merwin Xavier Agnes Maneesha , Ghosh Arnob , Rahman Sheikh Ifatur , Allerman Andrew , Verma Darpan , Myers Roberto C. , Arafin Shamsul , Rajan Siddharth 
Published: July 2023

Abstract
In this work, we demonstrate two-junction UV LEDs enabled by transparent tunnel junctions. Low voltage-drop tunnel junctions were realized in Al0.3Ga0.7N layers through a combination of high doping and compositional grading. Capacitance and current–voltage measurements confirmed the operation of two junctions in series. The voltage drop of the two-junction LED was 2.1 times that of an equivalent single-junction LED, and the two-junction LED had higher external quantum efficiency (147%) than the single junction.
Pregnancy-related anxiety level and associated factors in expectant fathers: case-control study in Turkey
Authors: KUŞ Celal , SUCAKLI Mustafa Haki , KOŞAR Yasar , ÇELIK Mustafa 
Published: July 2023

Introduction. In the prenatal period, fathers have a significant influence on the well-being of their children. Perinatal behavior and involvement of fathers during pregnancy are known to affect maternal health, fetal outcomes, and the emotions and behavior of the infant after birth. The aim of this study is to reveal the effects of pregnancy on the anxiety level of expectant fathers (EF) and the factors affecting the anxiety level.
Material and methods. This present paper is a case-control study conducted with the spouses of pregnant women who were followed up in healthcare institutions in Turkey between March and June 2016. This study was performed on 232 men with pregnant wives (expectant fathers) with no known chronic or psychiatric illnesses and 316 with non-pregnant wives. This study included men whose informed consent was obtained before being enrolled in the study. Two questionnaires (STAI forms (State-Trait Anxiety Inventory 1-2) and a questionnaire developed by the researcher) were applied to the participants.
Results. The mean age of EF was 33.7±6.0 (min=23, max=51). The mean age of men with non-pregnant wives (control group) was 36.5±7.1 (min=23, max=57). The frequency of anxiety in the EF was 9.9% for the STAI-1 and 10.7% for STAI-2. The frequency of anxiety in the control groups was 5.3% for the STAI-1 form and 2.5% for the STAI-2 form. In our study, the mean STAI-1 score of the EFs was 41.2±7.5, the mean STAI-1 score of the controls was 38.0±7.3, and there was a statistically significant difference between each other (p<0.001). The mean STAI-2 score of the EFs was 41.2±7.5, the mean STAI-2 score of the controls was 38.2±6.8, and there was a statistically significant difference between the two groups (p<0.001). The mean STAI-2 score of the EF group was 43.8±7.3 in the first trimester, 41.6±7.7 in the second trimester, and 39.6±7.0 in the third trimester. It was determined that spouses in the 1st trimester had higher anxiety levels than those in the second and third trimesters, according to the STAI-2 form (p=0.008). EF who had a postnatal babysitter, good sleep quality, did not experience a bad event, and were compatible with wives had a significantly lower level of anxiety (respectively p=0.008, p=0.019, p<0.001, p=0.01).
Conclusions. Particularly in first pregnancies and the first trimester of pregnancy, father candidates may experience anxiety disorders more frequently and intensely. EF may need psychological support during pregnancy. Physicians should evaluate the mother and the father-to-be from a psychological perspective.