bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Multimodal Extension of the Balakrishnan Alpha Skew Normal Distribution: Properties and Applications
Authors: SHAH SRICHARAN , Partha Jyoti Hazarika  , Dimpal Pathak  , Subrata Chakraborty  , M. Masoom Ali  
Published: March 2023

This paper introduces a new class of Balakrishnan distribution by extending the multimodal skew-normal distribution proposed by Chakraborty et al. (2015). Statistical properties of the new family of distributions are studied in detail. In particular, explicit expressions of the density and distribution function, moments, skewness, kurtosis and the moments generating function are derived. Furthermore, estimation of the parameters using the maximum likelihood method of the new family of distributions is considered. Finally, the paper ends with an illustration of real-life data sets and then comparing the value of Akaike Information Criterion and Bayesian information criterion of the new distribution with some other known distributions. For the nested models, the Likelihood Ratio Test is carried out.
Coagulación de aguas residuales mediante una mezcla de polvo de Crotalaria longirostrata y sulfato de aluminio
Authors: Pastrana-Pacho Alicia , Solis-Silvan Rudy , Ávila-Lázaro Israel , Laines-Canepa José Ramón , Sánchez-Díaz Baltazar 
Published: March 2023

Los coagulantes naturales a base de plantas se han usado para el tratamiento de aguas desde tiempos remotos y son amigables con el medio ambiente. El objetivo de este trabajo fue evaluar la capacidad de remoción de turbiedad y color de una mezcla coagulante de polvo Crotaloria longirostrata y sulfato de aluminio vs sulfato de aluminio. Se evaluó la dosis optima de sulfato de aluminio comercial y las mezclas coagulantes natural de polvo de C. longirostrata y sulfato de aluminio (tratamientos) que tuvieran la mayor remoción de turbiedad y color (variable respuesta) de un agua residual doméstica. Se utilizó un equipo de prueba de jarras marca PhilesMR para la determinación de las dosis optimas de coagulantes. La turbiedad y color se midieron con un turbidímetro marca LamoteMR. Se usó un diseño simple completamente aleatorizado de un factor y un análisis de varianza seguido de un contraste múltiple de Tukey para encontrar diferencias estadísticas significativas entre los diferentes tratamientos. Las mezclas de polvo de C. longirostrata con sulfato de aluminio (75 mg/L de polvo de C. longirostrata + 175 mg/L de sulfato) removieron una mayor cantidad de turbiedad y color que la dosis optima de sulfato de aluminio (250 mg/L), con remociones de 83.4% de turbiedad y 64.9% de color respectivamente. Los resultados lograron reducir un 30% el uso del sulfato de aluminio. El uso de polvo C. longirostrata como coadyuvante en la remoción de turbiedad y color no tiene efectos tóxicos ya que es un arbusto comestible.
Aktivitas Minyak Atsiri Bunga Lili (Lilium auratum) terhadap Bakteri Pseudomonas aeruginosa
Authors: Aryzki Saftia , Febrianti Dwi Rizki 
Published: March 2023

Infeksi yang disebabkan oleh bakteri Pseudomonas aeruginosa menjadi salah satu penyebab penyakit nosokomial. Potensi bahan alam seperti bunga lili belum banyak digali, komponen minyak atsiri bunga lili memiliki kandungan benzaldehid, linalol, simen, borneol dan osimen yang dapat bereaksi dengan komponen dinding sel bakteri yang menyebabkan kerusakan dinding sel bakteri. Tujuan penelitian ini ialah untuk mengetahui potensi minyak atsiri bunga lili (Lilium auratum) dalam menghambat pertumbuhan bakteri Pseudomonas aeruginosa dengan seri konsentrasi 12 μL, 25 μL, 50 μL menggunakan metode sumuran. Hasil uji didapatkan minyak atsiri bunga lili mampu menghambat bakteri dengan rata-rata zona hambat pada masing-masing minyak atsiri pada 12 µl sebesar 3,025 mm dengan kategori aktivitas rendah pada volume 25 µl sebesar 8,675 mm dengan kategori aktivitas sedang, dan pada volume 50 µl sebesar 13,018 mm dengan kategori kuat. Kata Kunci: Minyak Atsiri, Lilium auratum, Pseudomonas aeruginosa, Zona Hambat, Metode Sumuran Infections caused by the bacterium Pseudomonas aeruginosa are one of the causes of nosocomial diseases. The potential of natural materials such as lilies has not been explored much, the components of lili essential oil contain benzaldehyde, linalol, cement, borneol and osimen which can react with bacterial cell wall components causing damage to bacterial cell walls. The purpose of this study was to determine the potential of lili (Lilium auratum) essential oil in inhibiting the growth of Pseudomonas aeruginosa bacteria with a concentration series of 12 L, 25 L, 50 L using the disc method. The test results showed that lili essential oil was able to inhibit bacteria with an average inhibition zone of each essential oil at 12 l of 3.025 mm with a low activity category at a volume of 25 l of 8.675 mm with a moderate activity category, and a volume of 50 l of 13,018 mm with strong category.
Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
Authors: Zou Weiguo , Suo Jinlong , Shao Rui , Jinghui Wang , Yang Ruici , zhang zhong , Wang Duo , Niu Ningning , Zheng Xianyou 
Published: March 2023

Abstract
Osteoarthritis (OA) is an age-related degenerative disease without disease-modifying therapy. The lack of aging-induced osteoarthritis models makes the discovery of therapeutic drugs more challenging. The deficiency of integral membrane zinc metalloprotease ZMPSTE24 could induce Hutchinson-Gilford progeria syndrome (HGPS), a genetic disorder of rapid aging. However, the relationship between HGPS and OA remains unclear. Our results found that the expression of Zmpste24 was decreased in the articular cartilage during the aging process. Zmpste24 knock out mice, Prx1-Cre; Zmpste24fl/fl and Col2a1-CreERT2; Zmpste24fl/fl mice displayed OA phenotype. Loss of Zmpste24 in articular cartilage could exacerbate the occurrence and development of osteoarthritis. Transcriptome sequencing revealed that deletion of Zmpste24 or accumulation of progerin affects chondrocyte metabolism, inhibits cell proliferation and promotes cell aging. Using this animal model, we elucidate the upregulation of H3K27me3 during chondrocyte senescence and discover the molecular mechanism by which laminA mut stabilizes EZH2 expression. The construction of aging-induced osteoarthritis models and the elucidation of the signaling pathways and molecular mechanisms of articular chondrocyte senescence would benefit the discovery and development of new drugs for OA.
Understanding personal behavioral determinants in the decision-making of change agents from local politics and government in planning and implementing community health promotion: A qualitative study
Authors: Paulsen Lisa , Benz Lea , Müller Christina , Wallmann-Sperlich Birgit , Bucksch Jens 
Published: March 2023

Abstract
Background
Implementing environmental changes to promote healthier communities requires initial positive decisions by change agents from local politics and local government. However, there is little research on what influences the change agents' decisions. The aim of this explorative, qualitative study is to identify the personal behavioral determinants that influence the decision-making behavior of local change agents.
Methods
We conducted semi-structured interviews to assess the personal behavioral determinants of decision-making behavior among 22 change agents from local politics and local government. Relevant determinants were identified through a structured content analysis of the interview transcripts using the software MAXQDA 2020.
Results
We found the following seven essential personal behavioral determinants of the decision-making behavior of change agents from local politics and local government: Imprinting, socialization, and biography; experiences and involvement; important issues and aspects; knowledge; emotions; personal benefits; and the perceived influences of others.
Conclusions
The identified personal behavioral determinants might serve as a source of understanding the decision-making behavior of change agents in community decision-making processes. Our findings can contribute to the effective planning and implementation of evidence-based multilevel interventions related to changing environmental conditions in communities and provide important information on which factors should be considered when developing strategies for community health promotion. Future research should examine tailored methods and strategies for changing the personal behavioral determinants of the decision-making of change agents.
Correlation between white matter hyperintensity and delusional symptoms in Alzheimer's disease
Authors: Fan Wei , Ma Shaolun , Wang Ziqi , Han Yuanyuan , Liu Xiaowei , Gu Rui , Cai Qingyan 
Published: March 2023

Abstract
Background
Neuropsychiatric symptoms (NPSs) are exhibited in most patients with Alzheimer’s disease (AD), especially the delusional symptoms are commonly seen. Previous studies suggest that vascular changes such as white matter hyperintensities (WMH) have a significant association with specific NPS.The current study comparing the WMH volume in delusional and non-delusional Alzheimer's to explore the relationship between WMH and delusional symptoms in AD patients.
Methods
In total,80 AD patients divided into delusional group (n = 36) and non-delusional group (n = 44) according to the Neuropsychiatric Inventory(NPI) scale.The WMH volume of these 80 patients was quantitatively calculated.Include the whole Brain WMH volume, Periventricular WMH(PVWMH) volume, Deep WMH volume, bilateral frontal WMH volume, bilateral temporal WMH volume, bilateral parietal WMH volume and bilateral occipital WMH volume. Firstily,Compared the WMH volume between the delusional group and the non-delusional group.Sencondly,The delusional patients were divided into mild, moderate and severe groups according to the NPI. We Compared the different severity of delusional group to explore the role of WMH volume in delusional symptoms.
Results
There was a significant difference in WMH volume in the left occipital lobe (P < 0.05).In the delusional group, there were significant differences in the total volume of WMH and PVWMH volume (P < 0.05).Posthoc test showed that WMH volume were significantly different between mild and severe delusional symptoms (P < 0.05).
Conclusion
Left occipital WMH volume may affect the development of delusional symptoms.In AD patients, WMH promote the serious of delusional symptoms.
Circadian reprogramming of adipose progenitor cells regulates intermittent fasting-mediated adipose tissue remodeling and metabolic improvement
Authors: Lee Ju Hee , Patel Yash , Yeung Joanna , Pickel Lauren , Ealey Kafi , Togo Jacques , Kim Yun Hye , Kim Kyoung-Han , Park Jin-Gyoon , Jackson Timothy , Okrainec Allan , Kim Jae-Ryong , Park So-Young , Dash Satya , Sung Hoon-Ki 
Published: March 2023

Abstract
White adipose tissue (WAT) fibrosis is a hallmark of dysfunctional WAT that is directly linked to metabolic abnormalities. Recent studies have highlighted the role of dysfunctional adipose progenitor cells (APCs) in WAT fibrosis and impaired adaptive tissue plasticity, leading to systemic insulin resistance. However, therapeutic options for WAT fibrosis are limited. Intermittent fasting (IF) is an effective dietary regimen for weight control and metabolic improvement through various mechanisms, including healthy remodeling of WAT. However, whether IF is effective in improving age-associated WAT fibrosis and metabolic homeostasis is unknown. Here, we show that IF confers therapeutic benefits in aged and obese mice through reduction of WAT fibrosis. Single-cell analyses revealed that IF significantly reduces pro-fibrotic signatures within APCs along with upregulation of the circadian pathways, suggesting that the circadian clock of APCs mediates IF-induced WAT remodeling. Importantly, mice lacking core circadian gene exhibited increased fibrotic signatures in WAT and diminished beneficial response to IF, further supporting the importance of circadian rhythm in IF-mediated metabolic benefits. Lastly, insulin resistance in humans also presented with dysregulated circadian rhythm signatures in APC populations. Collectively, our findings highlight the novel role of the APC circadian rhythm in plasticity of WAT and metabolic response to IF.
Keys determinants of food insecurity in Sub-Saharan Africa
Authors: TCHIMEUTCHEU Fabrice Belmondo , NGONO Jean Marie ABEGA 
Published: March 2023

Abstract
This paper identifies the factors that contributed to the persistence of food insecurity (FI) in sub-saharan Africa (SSA) between 1990 and 2019. The sample consists of 29 countries with data obtained from the Food and Agricultural Organisation 2021, World Development Indicators 2021, International Country Risk Guide 2021 and Polity IV 2021 databases. We use the principal component analysis (PCA) to construct the composite food insecurity index. We then employ the average bayesian model (ABM) and the general to specific (GETS) approach for robustness to identify the main determinants of food insecurity in SSA. The PCA result reveals that FI in SSA results from the dimensions of food availability, food utilization and food stability. As for the ABM, results confirmed by the robustness of the GETS approach, indicated that income level, Arable land, demography and lack of democracy are the main determinants that favour FI in SSA. In contrast, rural population and education reduce FI. There is an urgent need in strengthening agricultural strategies and an inclusive distribution of national wealth followed by political accountability in other to fight against FI.
JEL: C11 C38 Q18
The Relationship between Longer Leukocyte Telomeres and dNCR in Non-Cardiac Surgery Patients: A Retrospective Analysis
Authors: Liu Chen , Abdul Mannan , Ding Ke , Sun Qing-Chun , Zhang Zhen-Feng , Dong Meng-Meng , Han Liu , Dai Ming-Sheng , Guan Hui-Lian , Han Yuan , Liu He , Chen Xue-Fen , Cao Jun-Li 
Published: March 2023

Abstract
Background: Postsurgical cognitive decline is a common complaint among older adults. While the mechanisms that contribute to this outcome are incompletely understood, leukocyte telomere length (LTL) can be measured as a form of a biological clock associated with individual lifespan. As such, LTL offers potential utility as an aging-associated biomarker that can be used to evaluate delayed neurocognitive recovery (dNCR) and related conditions.
Methods: For this study, 196 adults over 60 years of age scheduled to undergo major non-cardiac surgical procedures underwent neuropsychological testing pre-one day and the post-one week following surgery. The finding of dNCR was based on a measured Z-score ≤ -1.96 on two or more separate tests. The frequency of dNCR was presented as the primary outcome of the study. Secondly, we evaluated the association between dNCR and preoperative LTL.
Results: Overall, 20.4% [40/196; 95% confidence interval (CI), 14.7-26.1%] of patients exhibited dNCR at 1-week post-surgery. Longer LTL was identified as a predictor for the onset of early cognitive impairment resulting in post-operative cognitive decline [odds ratio (OR), 14.82; 95% CI, 4.01-54.84; P < 0.001], following adjustment of age (OR, 12.33; 95% CI, 3.29-46.24; P< 0.001). The dNCR incidence based on LTL values of these patients, the area under the receiver operating characteristic (ROC) curve was 0.79 (95% CI, 0.722-0.859; P <0.001). At an optimal cut-off value of 0.959, LTL values offered respective specificity and sensitivity values of 64.7% and 87.5%.
Conclusions: The incidence of dNCR was substantially correlated with the longer LTL. This biomarker may help identify patients at higher risk and clarify the etiology of dNCR.
Biomarkers associated with early onset of large submacular hemorrhage secondary to neovascular age-related macular degeneration after anti-VEGF intravitreal injection
Authors: Zegrari Samira , Cohen Salomon Yves , Colantuono Donato , Jung Camille , Souied Eric , Miere Alexandra 
Published: March 2023

Abstract
Objectives: To identify clinical and morphological biomarkers associated with early onset of large submacular hemorrhage (SMH) secondary to neovascular age-related degeneration (nAMD) after anti-vascular endothelial endothelial growth factor (anti-VEGF) intravitreal injection (IVI).
Methods: We retrospectively included patients presenting large SMH secondary to treated nAMD, for which at least 2 examinations, including spectral-domain optical coherence tomography (SD-OCT), were available prior to the onset of the SMH. Clinical characteristics, cardiovascular risk factors and treatment, as well as SD-OCT qualitative and quantitative variables were extracted at the 2 last examinations before SMH onset. History of previous SMH on the fellow eye was also documented. Early SMH onset at defined as <45 days versus > 45 days since last IVI were compared.
Results: Forty-six eyes of 46 patients were included in this study, of which 93% were undergoing pro-re-nata regimen with a monthly follow-up. Onion sign, persistence of exudative signs and increasing height of PED between the two last SD-OCT were associated with early SMH onset following last IVI. SMH was bilateral for 41% patients (19/46). In case of history of SMH on the fellow eye, the pre-existence of a RPE-tear before second SMH was significantly higher (p=0.029) in comparison to unilateral SMH.
Conclusion: Persistence of exudative signs,, onion sign and increasing PED height despite anti-VEGF intravitreal injections between the two last examination, as well presence of RPE tear in case of history of an SMH on the fellow eye, should be considered as warning signs for SMH.
Effect of fiber type and volume fraction on the mechanical properties of structural concrete
Authors: wang xianpeng , Wei Mingkun , S.N Kovshar , S.N Leonovich 
Published: March 2023

Abstract

In this paper, the mechanical and mechanical properties of two plant non-metallic fibers and one metallic fiber in concrete were analyzed. Design tests were conducted using two variable indicators of normal stress (σu/ MPa) and gradient fiber admixture (r/%). The flexural and compressive properties of reed fiber concrete, coconut fiber concrete, steel fiber concrete and plain concrete specimens were compared by the tests. It was concluded that both non-metallic fibers and metallic fibers can effectively improve the mechanical properties of structural concrete. According to the analysis of the experimental parameter diagram, the optimal dosing ratio of reed fiber and coconut shell fiber is 2%, and the optimal dosing ratio of steel fiber is 1.5%. In contrast, the impact toughness of metal fibers prompted the compressive performance of metal fibers is much stronger than non-metallic fibers, while the bending of non-metallic plant fibers can well improve the flexural strength of concrete prompted the flexural performance of non-metallic fibers is much higher than that of metal fibers. Therefore, the relationship between the mechanical stress of fiber concrete is: steel fiber concrete > reed fiber concrete > coconut fiber concrete.
Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis.
Authors: Ji Baowei , Liu Junchao , Yin Ye , Xu Hong , Shen Qian , Yu Jian 
Published: March 2023

Abstract
Minimal change disease (MCD) is a common type of nephrotic syndrome (NS) in children. Currently, there is an urgent need to explore the new treatments because of the significant side effects of long-term use of glucocorticoids and immunosuppressive drugs and the failure to reduce proteinuria in some patients. Angiopoietin-like protein 3 (Angptl3) is an essential target of NS, and anti-ANGPTL3-FLD monoclonal antibody (mAb) significantly reduces proteinuria in mice with AN. However, some proteinuria is persistent. Minnelide, a water-soluble prodrug of triptolide, has been used in China for the treatment of glomerular disease for > 40 years. Therefore, the present study aimed to investigate whether minnelide combined with mAb could further protect mice with AN and the underlying mechanisms. 8-week-old C57BL/6 female mice were injected with 25 mg/kg of Adriamycin (ADR) by tail vein to establish the AN model. A dose of 200 mg/kg of minnelide or 20 mg/kg of mAb was administered intraperitoneally for the treatment. In vitro, the podocytes were treated with 0.4 mg/mL of ADR for 24 h to induce podocyte injury, and pretreatment with 10 ng/mL of triptolide for 30 min or 100 ng/mL of mAb for 1 h before ADR exposure was used to treat. The results showed that minnelide combined with mAb almost completely ameliorates proteinuria and restores the ultrastructure of the podocytes in mice with AN. In addition, minnelide combined with mAb restores the distribution of Nephrin, Podocin, and CD2AP and reduces the level of inflammatory factors [tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β] in mice with AN. Mechanistically, minnelide combined with mAb alleviates apoptosis and promotes autophagy in mice with AN by inhibiting the mTOR signaling pathway. In vitro, triptolide combined with mAb increases the expression of Nephrin, Podocin, and CD2AP, alleviates apoptosis, and promotes autophagy by inhibiting the mTOR signaling pathway in ADR-induced podocyte injury. Overall, minnelide combined with mAb completely protects the mice with AN by promoting autophagy and inhibiting apoptosis.
Implementation research for mortality statistics development: Findings from Indonesia
Authors: Musadad Dede Anwar , Angkasawati Tri Juni , Usman Yuslely , Kelly Matthew James , Rao Chalapati 
Published: March 2023

Abstract
Civil Registration and Vital Statistics (CRVS) systems are the optimal source for data on births, deaths and causes of death for health policy, program evaluation, and research. In Indonesia, indicators such as life expectancy at birth, infant and maternal mortality rates, and cause-specific death rates need to be routinely monitored for national health policy. However, the CRVS system has not yet been fully established, which creates a challenge for evidence-based health action. In 2019, the Indonesian government released a national strategy for accelerating the CRVS system, with targets for improved coverage and data quality by 2024. This article describes findings from a program of formative and implementation research to guide the application of the national strategy. At first, a detailed CRVS assessment and gap analysis was undertaken using an international framework. The assessment findings were used to develop a revised business process model for reporting deaths and their causes at village, sub district and district level. In addition, a field instruction manual was also developed to guide personnel in implementation. Two field sites in Java – Malang District and Kudus Regency were selected for pilot testing the reporting procedures, and relevant site preparation and training was carried out. Data compilations for Malang in 2019 and Kudus in 2020 were analyzed to derive mortality indicators. High levels of death reporting completeness (83 to 89%) were reported from both districts, along with plausible cause-specific mortality profiles, although the latter need further validation. The study findings establish the feasibility of implementing revised death reporting procedures at the local level, as well as demonstrate sustainability through institutionalization and capacity building, and can be used to accelerate further development of the CRVS system in Indonesia.