bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in grey matter structure linked to frequency-specific cortico-subcortical connectivity in schizophrenia via multimodal data fusion
Authors: Duda Marlena , Faghiri Ashkan , Belger Aysenil , Bustillo Juan R. , Ford Judith M. , Mathalon Daniel H. , Mueller Bryon A. , Pearlson Godfrey D. , Potkin Steven G. , Preda Adrian , Sui Jing , Van Erp Theo G.M. , Calhoun Vince D. 
Published: July 2023

AbstractSchizophrenia (SZ) is a complex psychiatric disorder that is currently defined by symptomatic and behavioral, rather than biological, criteria. Neuroimaging is an appealing avenue for SZ biomarker development, as several neuroimaging-based studies comparing individuals with SZ to healthy controls (HC) have shown measurable group differences in brain structure, as well as functional brain alterations in both static and dynamic functional network connectivity (sFNC and dFNC, respectively). The recently proposed filter-banked connectivity (FBC) method extends the standard dFNC sliding-window approach to estimate FNC within an arbitrary number of distinct frequency bands. The initial implementation used a set of filters spanning the full connectivity spectral range, providing a unified approach to examine both sFNC and dFNC in a single analysis. Initial FBC results found that individuals with SZ spend more time in a less structured, more disconnected low-frequency (i.e., static) FNC state than HC, as well as preferential SZ occupancy in high-frequency connectivity states, suggesting a frequency-specific component underpinning the functional dysconnectivity observed in SZ. Building on these findings, we sought to link such frequency-specific patterns of FNC to covarying data-driven structural brain networks in the context of SZ. Specifically, we employ a multi-set canonical correlation analysis + joint independent components analysis (mCCA + jICA) data fusion framework to study the connection between grey matter volume (GMV) maps and FBC states across the full connectivity frequency spectrum. Our multimodal analysis identified two joint sources that captured co-varying patterns of frequency-specific functional connectivity and alterations in GMV with significant group differences in loading parameters between the SZ group and HC. The first joint source linked frequency-modulated connections between the subcortical and sensorimotor networks and GMV alterations in the frontal and temporal lobes, while the second joint source identified a relationship between low-frequency cerebellar-sensorimotor connectivity and structural changes in both the cerebellum and motor cortex. Together, these results show a strong connection between cortico-subcortical functional connectivity at both high and low frequencies and alterations in cortical GMV that may be relevant to the pathogenesis and pathophysiology of SZ.
Recent emergence of cephalosporin resistantSalmonellaTyphi in India due to the endemic clone acquiring IncFIB(K) plasmid encodingblaCTX-M-15gene
Authors: Priya T Tharani , Jacob Jobin John , Aravind V , Priya T Monisha , Shah Bhavini , Iyer Veena , Maheshwari Geeti , Trivedi Urmi , Shah Anand , Patel Pooja , Gaigawale Anushree , Yesudoss M , Narayanan Pavithra Sathya , Mutreja Ankur , Carey Megan , John Jacob , Kang Gagandeep , Veeraraghavan Balaji 
Published: July 2023

AbstractThe emergence and spread ofSalmonellaTyphi (S. Typhi) resistant to third-generation cephalosporins is a serious global health concern. In this study, we genomically characterized 142 cephalosporin-resistantS. Typhi strains isolated from India. Comparative genome analysis revealed the emergence of a new clone of ceftriaxone-resistantS. Typhi harboring three plasmids of the incompatibility groups IncFIB(K), IncX1, and IncFIB(pHCM2). Among these, the IncFIB(K) plasmid confers resistance to third-generation cephalosporins through theblaCTX-M-15gene, along with other resistance determinants such as aph(3“), aph(6’),sul2,dfrA14, qnrS,andtetA. Phylogenetic analysis showed that the isolates from Gujarat (n=140/142) belong to a distinct subclade (genotype 4.3.1.2.2) within genotype 4.3.1.2 (H58 lineage II). SNP-based phylogenetic analysis of the core genes in IncFIB(K) reveals a close genetic relationship between the plasmid backbone and that of IncFIB(K) from other Enterobacterales, suggesting that the H58 lineage II possesses the capability to acquire MDR plasmids from these organisms. This could indicate the potential onset of a new wave of ceftriaxone-resistantS.Typhi in India. The implementation of control measures such as vaccination, and improved water, sanitation, and hygiene (WASH) systems, is crucial in areas where MDR or XDRS. Typhi strains are prevalent to curb the spread and impact of these resistant strains.ImportanceTyphoid fever remains a significant public health problem in many parts of the world, particularly in resource-limited settings with inadequate sanitation and limited access to clean water. The emergence of MDRS. Typhiresistant to first-line antibiotics (chloramphenicol, ampicillin, and cotrimoxazole) and fluoroquinolones marked the initial treatment challenge, leading to reliance on azithromycin and third-generation cephalosporins. Recently, researchers identified the emergence of XDR typhoid in Pakistan that is resistant to five classes of antibiotics including third-generation cephalosporins. In this study, we report a recent emergence ofS. Typhi isolates resistant to third-generation cephalosporins. Genomic characterization and evolutionary analysis of the new strains revealed a recent acquisition ofblaCTX-Mcarrying IncFIB(K) plasmid led to the emergence of ceftriaxone-resistantS.Typhi. Due to the ongoing nature of this outbreak, the data from this study deserves further consideration in order to control its spread in India.
Fus3 interacts with Gal83, revealing the MAPK crosstalk to Snf1/AMPK to regulate secondary metabolic substrates in filamentous fungi
Authors: Ma Longxue , Xing Fuguo , Li Xu , Tai Bowen , Guo Ling 
Published: July 2023

AbstractThe pheromone MAPK is essential for the vital activities of fungi and is widely identified in filamentous fungi of agricultural, medical, and industrial relevance. The targets have rarely been reported and it is difficult to understand the mechanism of pheromone MAPK signaling pathway. Aflatoxins (AFs), highly carcinogenic natural products, are produced by the secondary metabolism of fungi, such asAspergillus flavus. Our previous studies demonstrated that Fus3 regulates AFs by modulating substrate levels inAspergillus flavus, but no mechanism explain that in fungi. Here we show Gal83, a new target of Fus3, and identified the pheromone Fus3-MAPK signaling pathway regulates the Snf1/AMPK energy-sensing pathway to modulate aflatoxins synthesis substrates. In the screening for target proteins of Fus3, the Snf1/AMPK complexes β subunit was identified by using tandem affinity purification and multi-omics, which physically interacted with Fus3 invivoandvitroand received phosphorylation from Fus3. While neither aflatoxin transcript levels were down-regulated ingal83-mutant andfus3-mutant strains, significant decreases in aflatoxin B1, aflatoxin synthetic substrates levels and gene expression levels of primary metabolic enzymes were shown that both the Fus3-MAPK and Snf1/AMPK pathways could response energy signal. In conclusion, all the evidence unlocks a novel pathway of Fus3-MAPK to regulate AFs synthesis substrates by cross-talking to the Snf1/AMPK complexes.ImportanceAflatoxin poses a great threat to human and animal health and the economy, thus the mechanisms regulating aflatoxin synthesis have been of great interest. We have previously demonstrated that MAPK regulates aflatoxin biosynthesis significantly, but the regulatory mechanism of Fus3-MAPK is not clear. Here we found that Pheromone Fus3-MAPK responds to energy and transmits to Snf1/AMPK through phosphorylation, which regulates the level of secondary metabolic substrates inAspergillus flavus, as a novel pathway of Fus3-MAPK. Fus3 interacts stably with Gal83 and colocalizes in the cytoplasm and nucleus, directly regulating the levels of aflatoxin synthetic substrates. These data advance our understanding of the regulation of aflatoxin by pheromone MAPK, and the mechanism of pheromone MAPK and Snf1/AMPK crosstalk regulation is confirmed. Overall, this has a positive effect on both fungal regulatory mechanisms and aflatoxin prevention and control.
A genetic code change in progress: tRNA-Leu(CAG) is conserved in mostSaccharomycopsisyeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation
Authors: Cinnéide Eoin Ó , Scaife Caitriona , Dillon Eugene , Wolfe Kenneth H. 
Published: July 2023

AbstractIn the yeast generaSaccharomycopsisandAscoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral tRNA-Leu gene with the same anticodon. One of these species,Ascoidea asiatica, has been shown to have a stochastic proteome in which proteins contain approximately 50% Ser and 50% Leu at CUG codon sites, whereas previously examinedSaccharomycopsisspecies translate CUG only as Ser. Here, we investigated the presence, conservation, and possible functionality of the tRNA-Leu(CAG) gene in the genusSaccharomycopsis. We analyzed the genomes of 33 strains, including almost all known species ofSaccharomycopsis, and found that most of them contain both tRNA-Ser(CAG) and tRNA-Leu(CAG) genes. The tRNA-Leu(CAG) gene is evolving faster than tRNA-Ser(CAG) and it has been lost in two species,S. microsporaandS. synnaedendra. We deleted the single tRNA-Leu(CAG) gene inS. capsularisand found that it is not essential. Bioinformatic analysis suggested that some CUG codon sites inSaccharomycopsisspecies may be translated as Leu, specifically in genes with functions in meiosis or sporulation, but mass spectrometry of sporulatingS. capsularisandS. fermentanscultures showed only CUG-Ser translation. Cloverleaf structures of tRNA-Leu(CAG) from allSaccharomycopsisspecies contain mutations that are likely to make them non-functional in translation, but the evolutionary conservation of the gene leads us to propose that it has been retained for an unknown non-translational role.
Augmented Super-Resolution Radial Fluctuations (aSRRF) Pushing the Limits of Structured Illumination Microscopy
Authors: Zhang Heng , Wang Jianhang , Jin Luhong , Zhu Yunqi , Guo Yuting , Zhang Meng , Zhang Yuhui , Wang Zhixiong , Su Yisun , Wu Yicong , Ji Baohua , Toomre Derek , Liu Xu , Xu Yingke 
Published: July 2023

AbstractStructured illumination microscopy (SIM) is a versatile super-resolution technique known for its compatibility with a wide range of probes and fast implementation. While 3D SIM is capable of achieving a spatial resolution of ∼120 nm laterally and ∼300 nm axially, attempting to further enhance the resolution through methods such as nonlinear SIM or 4-beam SIM introduces complexities in optical configurations, increased phototoxicity, and reduced temporal resolution.Here, we have developed a novel method that combines SIM with augmented super-resolution radial fluctuations (aSRRF) utilizing a single image through image augmentation. By applying aSRRF reconstruction to SIM images, we can enhance the SIM resolution to ∼50 nm isotopically, without requiring any modifications to the optical system or sample acquisition process. Additionaly, we have incorporated the aSRRF approach into an ImageJ plugin and demonstrated its versatility across various fluorescence microscopy images, showcasing a remarkable two-fold resolution increase.
The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release relies on the integrity of the C-terminal half of the SNARE domain of Syntaxin-1A
Authors: Salazar-Lázaro Andrea , Trimbuch Thorsten , Vardar Gülçin , Rosenmund Christian 
Published: July 2023

AbstractThe SNARE proteins are central in membrane fusion and, at the synapse, neurotransmitter release. However, their involvement in the dual regulation of the synchronous release while maintaining a pool of readily releasable vesicles remains unclear. Using a chimeric approach, we performed a systematic analysis of the SNARE domain of STX1A by exchanging the whole SNARE domain or its N- or C-terminus subdomains with those of STX2. We expressed these chimeric constructs in STX1-null hippocampal mouse neurons. Exchanging the C-terminal half of STX1’s SNARE domain with that of STX2 resulted in a reduced RRP accompanied by an increased release rate, while inserting the C-terminal half of STX1’s SNARE domain into STX2 lead to an enhanced priming and decreased release rate. Additionally, we found that the mechanisms for clamping spontaneous, but not for Ca2+-evoked release, are particularly susceptible to changes in specific residues on the outer surface of the C-terminus of the SNARE domain of STX1A. Particularly, mutations of D231 and R232 affected the fusogenicity of the vesicles. We propose that the C-terminal half of the SNARE domain of STX1A plays a crucial role in the stabilization of the RRP as well as in the clamping of spontaneous synaptic vesicle fusion through the regulation of the energetic landscape for fusion, while it also plays a covert role in the speed and efficacy of Ca2+-evoked release.
Work–life balance in the construction industry: a bibliometric and narrative review
Authors: Adah Christiana Ada , Aghimien Douglas Omoregie , Oshodi Olalekan 
Published: July 2023

PurposeThe nature of construction works has a negative impact on physical, mental and emotional well-being and makes it difficult for the construction industry to attack and retain its workforce. The current study seeks to integrate the current knowledge focused on work–life balance (WLB) in the industry into an understandable whole.Design/methodology/approachAn interpretivist philosophical approach was adopted using a bibliometric review and a narrative review of existing studies from both Scopus and Google databases. The Visualisation of Similarities viewer (VOSviewer) was used to prepare co-occurrence maps from the bibliographic data garnered.FindingsThe study reveals that the prominent factors influencing the WLB of the construction workforce are organizational culture, salary earned, heavy workload, long working hours and inflexible working time. The recent WLB discourse is on organisational commitment, job satisfaction and workplace dynamics. While WLB areas for further exploration are job stress, safety performance, employee attrition and an ageing workforce. Meanwhile, Africa and South America are still lagging in WLB research.Practical implicationsThe findings reported here will assist stakeholders in identifying appropriate WLB initiatives that can be used to improve the well-being of the construction workforce. Also, the gaps in knowledge for further research were highlighted.Originality/valueThe findings reveal current trends and a road map for future studies on WLB in construction. It also reveals prominent factors influencing the WLB of workers in the construction industry.
Incorporating counterproductive knowledge behaviour in the higher education context: proposing the potential remedies in explaining the faculty members’ performance
Authors: Zamrudi Zakky , Setiawan Margono , Irawanto Dodi Wirawan , Rahayu Mintarti 
Published: July 2023

Purpose
This study aims to seek to understand counterproductive knowledge behaviour (CKB) in higher education institutions (HEIs) by integrating knowledge hiding (KHi) and lack of knowledge sharing (LKS).

Design/methodology/approach
The current research uses a hybrid conceptual review combining the bibliometric study and conceptual review of 47 articles. The bibliometric analysis aimed to identify research maps, and the conceptual review sought to understand the current development of research fields.

Findings
The bibliometric analysis highlights essential summaries, such as the pioneering authors, seminal papers and conceptual maps. However, knowledge hoarding as a dimension of LKS appears in the niche theme. The conceptual analysis indicates three groups of factors contributing to KHi and LKS. Moreover, the study highlights the causal relation between both KHi as well as LKS and faculty member performance while proposing remedies derived from integrating the social exchange theory (SET) and conservation of resource (COR) theory.

Research limitations/implications
The present study provides an integrated image of KHi and LKS in the HEI context, as well as its potential remedies by integrating SET and COR. The basis of this study is a literature review; thus, future studies are recommended to empirically explore the integration of KHi and LKS within the HEI context.

Practical implications
This research provides an overview for HEI policymakers to re-examine the critical role of institutional research as one of the considerations for evaluating and developing policies. Specifically, policymakers can reflect on all policy directions to determine whether there are any symptoms of CKB in the institutions. Moreover, stakeholders can find out the reason behind the non-optimal performance of faculty members regarding CKB and any mitigating factors.

Originality/value
Understanding CKB is crucial in managing HEI. This research provides a comprehensive image of KHi and LKS within HEI, especially in a collectivist culture.
Does religiosity matter in the workplace? A moderated-mediated examination of abusive supervision, revenge and deviance
Authors: Ahmad Saima , Dar Nasib , Rahman Wali 
Published: July 2023

Purpose
This paper aims to investigate the influence of religiosity on the relationship between abusive supervision and deviant work behavior (DWB). This paper examines whether the desire for revenge mediates the relationship between abusive supervision and DWB and whether the strength of this relationship is moderated by religiosity.

Design/methodology/approach
The proposed relationships were examined by collecting primary data from 350 employees using multistage sampling procedures. Hayes’ Process Macro was used to analyze the proposed moderated-mediation model of abusive supervision, DWB, religiosity and desire for revenge.

Findings
The analytical findings indicate that an employee’s desire for revenge mediates the relationship between abusive supervision and DWB. However, religiosity moderates the indirect effect of abusive supervision (mediated by the desire for revenge) on DWB.

Originality/value
To the best of the authors’ knowledge, this is the first study that explores the role of individual-level religiosity in mitigating the harmful effects of abusive supervision on deviant behavior and revenge in the workplace.
Forecasting law enforcement frequency of internet+ coal mine safety supervision
Authors: Long Yuzhen , Yang Chunli , Li Xiangchun , Lu Weidong , Zhang Qi , Gao Jiaxing 
Published: July 2023

PurposeCoal is the basic energy and essential resource in China, which is crucial to the economic lifeline and energy security of the country. Coal mining has been ever exposed to potential safety risks owing to the complex geologic environment. Effective safety supervision is a vital guarantee for safe production in coal mines. This paper aims to explore the impacts of the internet+ coal mine safety supervision (CMSS) mode that is being emerged in China.Design/methodology/approachIn this study, the key factors influencing CMSS are identified by social network analysis. They are used to develop a multiple linear regression model of law enforcement frequency for conventional CMSS mode, which is then modified by an analytical hierarchy process to predict the law enforcement frequency of internet+ CMSS mode.FindingsThe regression model demonstrated high accuracy and reliability in predicting law enforcement frequency. Comparative analysis revealed that the law enforcement frequency in the internet+ mode was approximately 40% lower than the conventional mode. This reduction suggests a potential improvement in cost-efficiency, and the difference is expected to become even more significant with an increase in law enforcement frequency.Originality/valueTo the best of the authors’ knowledge, this is one of the few available pieces of research which explore the cost-efficiency of CMSS by forecasting law enforcement frequency. The study results provide a theoretical basis for promoting the internet+ CMSS mode to realize the healthy and sustainable development of the coal mining industry.
Agricultural resources and practices in the circular bioeconomy adoption: evidence from a rural region of Greece
Authors: Papadopoulou Christina-Ioanna , Loizou Efstratios , Chatzitheodoridis Fotios , Karelakis Christos 
Published: July 2023

PurposeThis study aims to assess the factors influencing the adoption of circular bioeconomy practices by crop farmers.Design/methodology/approachData collected from 303 farmers in the region of Western Macedonia (WM) were used to identify the adoption factors of the circular bioeconomy. Principal component analysis (PCA) and exploratory factor analysis (EFA) techniques were applied through a custom-designed and specially structured questionnaire.FindingsThe results reveal four main motivations that lead farmers to adopt circular bioeconomy practices in their farming activities: interest in physical-economic resources and factors related to production and consumption; technology and renewable energy and the environment.Research limitations/implicationsThis study is based solely on farmers in WM. Furthermore, this study assumes that there will be a strategy to promote a circular bioeconomy under the auspices of the government.Originality/valueFew studies have focused on the perspectives of crop farmers and what encourages them to adopt circular bioeconomy practices in their crops. Existing barriers are related to economic incentives and constraints. The more circular bioeconomy practices farmers adopt, the greater the positive impact on the environment and rural development, and the factors influencing the adoption of these practices are investigated here.
The data-driven leader: developing a big data analytics leadership competency framework
Authors: Schmidt David Holger , van Dierendonck Dirk , Weber Ulrike 
Published: July 2023

PurposeThis study focuses on leadership in organizations where big data analytics (BDA) is an essential component of corporate strategy. While leadership researchers have conducted promising studies in the field of digital transformation, the impact of BDA on leadership is still unexplored.Design/methodology/approachThis study is based on semi-structured interviews with 33 organizational leaders and subject-matter experts from various industries. Using a grounded theory approach, a framework is provided for the emergent field of BDA in leadership research.FindingsThe authors present a conceptual model comprising foundational competencies and higher order roles that are data analytical skills, data self-efficacy, problem spotter, influencer, knowledge facilitator, visionary and team leader.Research limitations/implicationsThis study focuses on BDA competency research emerging as an intersection between leadership research and information systems research. The authors encourage a longitudinal study to validate the findings.Practical implicationsThe authors provide a competency framework for organizational leaders. It serves as a guideline for leaders to best support the BDA initiatives of the organization. The competency framework can support recruiting, selection and leader promotion.Originality/valueThis study provides a novel BDA leadership competency framework with a unique combination of competencies and higher order roles.