bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porphyromonas gingivalis, a periodontal pathogen, Impairs Post-infarcted Myocardium by Inhibiting Autophagosome–Lysosome Fusion
Authors: Shiheido-Watanabe Yuka , Nakagama Shun , Fan Qintao , Tamura Natsuko , Sasano Tetsuo , Maejima Yasuhiro 
Published: June 2023

Abstract

While several previous studies have indicated the link between periodontal disease (PD) and myocardial infarction (MI), the underlying mechanisms remain unclear. Autophagy, a cellular quality control process that is activated in several diseases, including heart failure, can be suppressed by Porphyromonas gingivalis (P.g.). However, it is uncertain whether autophagy impairment by periodontal pathogens stimulates the development of cardiac dysfunction after MI. Thus, this study aimed to investigate the relationship between PD and the development of MI while focusing on the role of autophagy. Neonatal rat cardiomyocytes (NRCMs) and MI model mice were inoculated with wild-type P.g. or gingipain-deficient P.g. to assess the effect of autophagy inhibition by P.g. Wild-type P.g.-inoculated NRCMs had lower cell viability than gingipain-deficient P.g.-inoculated NRCMs. The study also found that gingipain cleaves vesicle-associated membrane protein 8 (VAMP8), a protein involved in lysosomal sensitive factor attachment protein receptors (SNAREs), at the 47th lysine residue, inhibiting autophagy. Wild-type P.g.-inoculated MI model mice were more susceptible to cardiac rupture, with lower survival rates and autophagy activity than gingipain-deficient P.g.-inoculated MI model mice. Genetically modified MI model mice (VAMP8-K47A) were inoculated with wild-type P.g., and they exhibited significantly increased autophagy activation compared to wild-type P.g.-inoculated MI model mice, which suppressed cardiac rupture and enhanced overall survival rates. These findings suggest that gingipains, virulence factors of P.g., impair the infarcted myocardium by cleaving VAMP8 and disrupting autophagy. This study confirms the strong association between PD and MI and provides new insight into the potential role of autophagy in this relationship.
Findings of Cardiovascular Workup of Kidney Transplant Candidates: A Retrospective Study of a Single-Center in Saudi Arabia
Authors: Arabi Ziad , Tawhari Mohammed H. , Rajih Haneen S. Al , Youssouf Talha M. , Abdulgadir Mohamad Y. 
Published: June 2023

Abstract
Background: There are limited data about the prevalence of cardiovascular (CV) risk factors and the findings of CV workup among kidney transplant (KTx) recipients (KTRs) in Saudi Arabia.
Method: A single-center retrospective study of KTRs who underwent KTx from 2017 to 2020. We reviewed the prevalence of CV risk factors and the results of the pre-KTx CV workup which was derived from the American Heart Association guidelines.
Results: We included 254 KTRs. The mean age was 43.1±15.9 years, 55.5% were men and 79.5% were living-donor KTRs. Pre-emptive KTx was 9.8%, peritoneal dialysis: 11.8% and hemodialysis: 78.3% (arteriovenous fistula: 33.1% versus hemodialysis catheter: 66.9%). Mean dialysis vintage was 4.8±3.3 years for deceased-donor KTRs versus 2.4±2.6 years for living-donor KTRs.
CV risk factors were hypertension: 76%, diabetes: 40.6% (type 1: 25.2% versus type 2: 74.7%), hyperlipemia (low-density lipoprotein> 2.6 mmol/L): 40.2%, coronary artery disease (CAD): 12.6%, smoking: 9.1%, peripheral vascular disease: 2.8%, and cerebral vascular disease: 2.4%. The prevalence of obesity stage 1 was 19.7% and obesity stage 2 was 4%.
Left ventricular hypertrophy was present in 38.5%. Ejection fraction was abnormal (<55%) in 22%. Abnormal wall motion was present in 34 patients (13.4%). Cardiac (PET-CT) stress test was indicated in 129 patients (50.8%) and showed abnormal perfusion in 37 patients (28.7%). Out of those who required PET-CT, 18.6% had coronary artery calcium scoring (CACS) more than 400, 41.8 had CACS of zero, 29.4% had CACS of 1-100, and 14.7% had CACS of 100-400.
Coronary angiogram was required in only 41 patients (16.1%), 12 (29.3%) required coronary interventions, 25 (61%) were treated medically, and 4 (9.8%) did not have any CAD.
CT scans of pelvic arteries were performed in 118 patients (46.5%). It showed moderate or severe calcifications in only 7 patients (5.9%), whereas it was normal in 97 patients (82.2%), or it showed only mild calcifications in 14 patients (11.9%).
Conclusion:
This study outlines the prevalence of CV risk factors and the findings of the pretransplant CV workup among KTx candidates who underwent KTx. Multicenter national studies will be helpful to validate the generalizability of these findings.
Relationship of thyroid function with renal hemodynamics and cholesterol metabolism in proteinuric kidney disease: A retrospective pilot study
Authors: Iwazu Yoshitaka , Kotani Kazuhiko , Sugase Taro , Nagata Daisuke , Yamada Toshiyuki 
Published: June 2023

Abstract
Back ground.
Massive proteinuria and hypothyroidism are respectively reported to influence renal hemodynamic and hypercholesterolemia. However, the relationship of proteinuria-associated thyroid function with renal hemodynamics and cholesterol metabolism has yet to be determined in a simultaneous analysis of thyroid, renal and cholesterol variables. We investigated the hypothesis that the changes in thyroid hormones by proteinuria may contribute to changes in lipid metabolism and renal hemodynamics by proteinuria.
Methods.
Twenty-nine patients (17 men) with proteinuric kidney disease (mean age 46 years) were enrolled in a pilot study. Data for serum free triiodothyronine (FT3), free thyroxine (FT4), total cholesterol, and filtration fraction (FF; assessed by para-aminohippuric acid clearance) were used in variable-adjusted correlation analyses.
Results.
The patients had the following data (mean ± standard deviation): urinary protein 5.18 ± 3.28 g/day, FT3 2.18 ± 0.44 pg/mL, FT4 1.03 ± 0.26 ng/dL, FF 0.27 ± 0.07, and total cholesterol 327 ± 127 mg/dL. There was a significant positive correlation of FT3 with FF (β = 0.58, P = 0.01) and a significant inverse correlation of FT4 with total cholesterol (β = -0.40, P = 0.01).
Conclusions.
The proteinuria associated reduction in serum thyroid hormone levels may be involved in a part of hypercholesterolemia and the impaired glomerular function due to massive proteinruia. Further studies of these relationships are required.
Environmentally-Driven Morphogenesis of Reconfigurable Floating Robots using Markov Models
Authors: Obayashi Nana , Meyer Germain , Junge Kai , Hughes Josie 
Published: June 2023

Abstract
The morphology and structure plays a crucial role in shaping the behavior and functionality of both biological and robotic systems.In this work, we are inspired by morphogenesis, a fundamental biological process which encompasses the emergence of organs and organism morphology. It is driven by both internal and environmental factors and profoundly influences cellular behavior during development. By studying the environmental-driven properties that give rise to specific cellular morphologies, we investigate how control of the environment can be harnessed to trigger structural changes. Furthermore, we explore the potential application of these principles to inspire the development of robots with predefined morphologies. However, this endeavor is inherently stochastic and challenging to simulate accurately. To address this complexity, we propose leveraging a Markov decision process-inspired controller, guided by a Markov model. Using this approach, we can achieve decentralized control instead of localized control and design scalable robotic systems that can reconfigure their morphologies and display different motion characteristics in response to environmental cues.
How to Get your Institution into the Top 200 in NIRF Ranking?
Authors: Naveen Palanichamy 
Published: June 2023

Abstract
Education pays success to individual growth. It expands from an individual to a society. Development of today’s growth across the globe is not possible without education. In this article, we focus on higher education. How the quality of higher equation is evaluated and why it is necessary. The discussion starts with accreditation bodies and then the world university ranking. Finally narrow down to Indian Ranking. In the Indian Ranking, the role of NIRF to improve the quality of education throughout the nation in the past 8 years. In order to elevate the institute to the next level, the focussing areas for the leadership of the institution are tabulated as different metrics. Expected values to be a top 200 institution for the NIRF 2023 are derived. To predict the value, previous four-year results were analyzed and are explained throughout the article. Thus, this article helps in understanding the NIRF process with the predicting values for the upcoming year.
A New Generalized Truncated K–series Fractional Derivative
Authors: LEMNAOUAR Mohamed Reda , LOUARTASSI Younes , ZINE Rabie 
Published: June 2023

Abstract
This paper proposes a new fractional derivative denoted by K–Fractional Truncated Derivative (K–FTD). K–FTD generalizes several existing fractional derivatives found in the literature including the conformable derivative, the truncated alternating derivative, the truncated M-fractional derivative, and the truncated M- series fractional derivative. Furthermore, it also satisfies the same properties of ordinary derivatives such as linearity, product rule, and chain rule. In this respect, some classical results of the ordinary derivative such as Rolle's theorem and the mean value theorem are extended. Then, the K–fractional Integral is introduced, and the truncated K–fractional derivative, as well as the fractional integral of some orders α ∈ (n; n + 1], are defined. Finally, analytical solutions have been obtained for some differential and partial differential equations of fractional order α ∈ (0;1] to demonstrate the described approach.
Mathematics Subject Classification : 26A06, 26A24, 26A33, 26A39, 26A42.
Joint geometry-semantic 3D point cloud filtering
Authors: Haque Sk. Mohammadul 
Published: June 2023

Abstract

Recently, a significant amount of research in the vision community has been done in the 3D-geometry estimation problems in one hand and semantics segmentation on the other. In this paper, we establish and study a probabilistic framework to refine 3D-geometry and semantics jointly from their noisy estimates obtained independently. Specifically, in our probabilistic framework, we investigate how one can benefit the estimation of the other. We then discuss the implementation details and finally present experimental results that depict the behaviour of the solution under varying conditions.
COVID-19 Coinfection with Malaria and Its Presentation with Bilateral Pleural Effusion: A Case Report and Literature Review
Authors: Solela Gashaw , Aschenek Addis , Dawit Mikale , Wondafrash Getachew 
Published: June 2023

Abstract
Background
There could be misdiagnosis of COVID 19 for malaria and vice versa because of their similar presentation, particularly when clinician relies mainly on symptoms. Coinfection with COVID-19 and malaria is associated with increased all-cause in-hospital mortality compared to isolated infection with SARS-CoV-2. Presentation with pleural effusion adds another challenge in the diagnosis of COVID-19.
Case summary:
This is a 57-year-old woman who presented with symptoms of acute febrile illness associated with shortness of breath and cough. Physical examination was remarkable for fever, hypotension, tachycardia, tachypnea, desaturation, decreased air entry and dullness over bilateral lower 1/3rd of the chest. Upon investigations, she was found to have ring-form trophozoites of plasmodium falciparum and bilateral ground glass opacities, bilateral consolidations and bilateral pleural effusions. She was managed with supportive treatments, antimalarial agents and antibiotics. COVID-19 was diagnosed late due to the initial high diagnostic inertia.
Conclusion
Clinicians should be aware of the possibility of COVID-19 in any patient who presents with acute febrile illness or respiratory complaints like shortness of breath and cough. In patients with symptoms such as fever, fatigue, and headache, both malaria and COVID-19 tests should always be performed. Though pleural effusion is rarely reported in COVID-19 patients, viral etiologies like COVID-19 should be considered if alternative diagnoses are lacking.
Clinical outcomes of Short Rod Technique in posterior lumbar interbody fusion surgery: A Minimum of 2-year follow-up
Authors: Yang Mingyuan , Pu Lianjie , Liu Shu , Hou Canglong , Li Xiaolong , Li Bo , Huang Zebin , Song Yuanjin , Mao NingFang , Bai Yushu , Li Ming 
Published: June 2023

Abstract
Purpose
We first introdue a novel entry point of pedicle screws (Short Rod Technique, SRT), which could avoid violation of superior facet and has been verified as a safe screw placement method. The aim of this study is to detcte the clinical outcomes of SRT in posterior lumbar interbody fusion (PLIF) surgery.
Methods
89 patients who received SRT and 109 patients who received PLIF surgery with regular entry point of pedicle screws were recruited with a minimum of 2-year follow-up. Patientes were further divided into three groups according to the number of fusion segments, and clinical outcomes including surgical variables, radiological parameters and HRQOL were analyzed and compared.
Results
The length of wound and the length of rods was sigificantly shorter in SRT group in both patients fused with single segment, two segments and three segments, respectively. Less intraoperative blood loss was observed in SRT group in patients fused with single segment and two segments, rather than three segments. Less degenerations of upper adjacent segment were observed in SRT group in both patients fused with single segment and three segments. In addition, less postoperative wound pain was observed in PLIF surgery with SRT group in patients fused with two and three segments.
Conclusion
SRT was an effective technique and good clinical outcomes were observed, especially for the reduction of the occurrence of upper ASD in PLIF surgery with single segment and three segments. We hope this article could provide a novel method for spinal surgeons in PLIF surgery.
A greedy randomized adaptive search procedure for scheduling IoT tasks in virtualized fog-cloud computing
Authors: Salimi Rezvan , Azizi Sadoon , Abawajy Jemal 
Published: June 2023

Abstract

Virtualized fog-cloud computing (VFCC) has become an ideal platform for processing the growing number of emerging Internet of Things (IoT) applications. VFCC resources are provided to IoT applications as a set of virtual machines (VMs). How VMs may be used efficiently for performing IoT tasks with various requirements is a primary challenge considering that they are heterogeneous in terms of processing power, communication delay, and energy consumption. In order to deal with this problem, we initially present a system model for scheduling IoT tasks in VFCCs, that considers not only each task's deadline but also the system's energy consumption. Then, a greedy randomized adaptive search process (GRASP) is utilized to determine the optimal assignment of IoT tasks among VMs. GRASP is a metaheuristic-based technique that provides several appealing characteristics, such as simplicity and ease of implementation, a limited number of tuning parameters, and the capability of parallel implementation. We conducted comprehensive experiments to evaluate the efficacy of the proposed method and compared its performance to that of the most advanced algorithms. Extensive experiments show that the proposed technique is superior to the baseline method in terms of deadline satisfaction ratio, average response time, energy consumption, and makespan.
A Fuzzy Ontology-based Context-aware Encryption approach in IoT through Device and Information Classification
Authors: Dar Zainab , Ahmad Adnan , Zeshan Furkh , Malik Tariq 
Published: June 2023

Abstract

IoT devices produce a vast amount of data ranging from personal to sensitive information. Usually, these devices remain connected to the internet so protecting the information produced by them is crucial. Since most of the IoT devices are resource-constrained, they must be supported with light-weight encryption standards to protect information. Recent research has used the concept of context awareness to select the most suitable data encryption standard based on the device resources along with the required information confidentiality level. However, to effectively use the context information, it is required to be organized explicitly while considering the dynamic nature of IoT systems. In this regard, ontology-based systems effectively reduce the volume of manual work while recommending solutions. Currently, these systems cannot work with precision due to multiple uncertain factors of IoT sensory data,. To overcome this challenge, this research proposes a fuzzy ontology-based context-aware system to protect IoT device information with the help of an encryption algorithm that considers device capabilities and user priorities regarding the data confidentiality. In-order to automate the recommendation process, Semantic Web Rule Language (SWRL) rules and fuzzy logic are used, whereas, Description Logic and RDF Query Language is used to evaluate the results. The evaluation results confirm that the proposed method can produce results according to human perception by significantly increasing the accuracy of prediction.
Analysis of Steel Electrical-Resistance Kinetics during High-Temperature Experiments using an Embedded System
Authors: Chávez-Campos Gerardo Marx , Campos Yason Yair Chávez , Vergara-Hernández Héctor Javier , Vazquez-Gómez Octavio , Campos Pascual Neftali Chávez , Arreola-Villa Sixtos Antonio 
Published: June 2023

Abstract
Metals’ properties can be enhanced through high-temperature treatments. These treatments can also enhance the mechanical properties of metals, such as strength, hardness, and ductility. This is achieved by altering the microstructure of the metal, which can improve its ability to withstand stress and deformation. To ensure the effectiveness of the processes, samples undergo mechanical and optical characterization. During high-temperature treatments, oxidation kinetics is often studied through controlled experiments. However, traditional methods involve a complicated, time-consuming, and iterative process to track oxidation changes at different intervals, leading to limited data. This paper proposes the use of metals’ electrical resistance as a method to monitor oxidation kinetics during high-temperature experiments with AISI-304. An embedded system has been developed to control and record pertinent experimental data. The four-point method, backed by the Ordinary Least-Square Estimator, is employed to measure electrical resistance. Data analysis shows an increase in resistance value, which is attributed to the loss of mass/area caused by high-temperature oxidation.
POLITIK DAN “TEATER RITUAL” DI BALI
Authors: Suryawan I Ngurah 
Published: June 2023

The relation between ritual and socio-political environment should become a deep reflection. Rituals which take place in order for salvation, harmony, and natural balance instead generate the ambigue and ironic situation. Rituals had been going on amazingly but the social as well as natural disasters seems go on continually. In Bali, religious rituals that formerly guarded by mantra-mantra (spiritual wordings) recently enstead by a group of Pecalang (tradition guardian in Bali) and metal detector (at the time of Pamarisudha Karipubhaya Bali Blast of 2002 and 2005). Nowadays Balinese are eager to perform rituals spectacularly. But instead, Bali now is struck by continous disaster, not only the disaster came from external sources but also the internal ones.***Hubungan antara ritual dengan lingkungan sosial politik harus menjadi bahan renungan yang dalam. Ritual yang dilaku­kan untuk tujuan keselamatan, harmoni, dan ke­seimbang­an alam bahkan menimbulkan kondisi ambigue dan ironis. Ritual berjalan secara mengesankan namun bencana sosial maupun bencana alam terus menerus terjadi. Di Bali, ritual agama yang sebelumnya diwarnai mantra-mantra kini diisi oleh Pecalang (pengawal tradisi Bali) dan metal detector (pada saat Pamarisudha Kariphaya Bom Bali 2002 dan 2005). Kini orang Bali cenderung melaksanakan ritual secara spektakuler. Akan tetapi Bali seringkali didera ben­cana, baik bencana yang berasal dari dalam maupun luar.
SUFI HEALING: TERAPI DALAM LITERATUR TASAWUF
Authors: Syukur Muhammad Amin 
Published: June 2023

This study reveals the Sufi healing, a therapy in the literature of Sufism. This study focuses on behaviors associated with the Sufi healing or prevention of disease, both physically and mentally, and then determines the aspects that support a system of rational and empirical therapy. The result achieved through this research is the discovery of an alternative treatment or prevention of appropriate disease in accordance with the tendency of society in the current era, the digital age. After investigation, it is revealed that Sufi healing is a form of alternative therapy that is done by taking the values of Sufism as a means of treatment or prevention. This model has been known in the community since Islam and Sufism itself evolved. Scientific references about the work system of medicine or healing in this manner, was found in a variety of transpersonal psychology theories, in which consciousness become one focus of the study. Medically, it is also known by the term psycho-neurons- endocrine-immunology, where the conclusion states that there is a relationship between mind and body in the health problems for everyone. In other word, the mind influences health.***Kajian ini mengungkap tentang sufi healing, yaitu terapi di dalam literatur tentang sifisme. Kajian ini memfokuskan pada perilaku yang berasosiasi dengan sufi healing atau pencegahan penyakit, baik secara fisik maupun mental, dan kemudian menentukan aspek-aspek yang mendukung sistem terapi rasional dan empirik. Hasil yang diperoleh dari kajian ini adalah penemuan treatment alternatif atau preventif terhadap penyakit secara tepat yang sesuai dengan tuntutan masyarakat saat ini. Ditemukan bahwa sufi healing merupakan bentuk terapi alternatif yang dilakukan dengan menggunakan nilai-nilai sufisme se­bagai cara treatment atau pencegahan. Model ini telah dikenal dalam ma­syarakat sejak Islam dan sufisme berkembang. Rujukan ilmiah dari mengenai sistem kerja peng­obatan­nya dapat ditemukan dalam berbagai teori psikologi transpersonal, di mana kesadaran menjadi fokus kajian. Secara medis, pengobatan ini juga disebut psycho-neurons-endocrine-immunology, yang kesimpulannya adalah adanya hubungan antara fikiran dan tubuh dalam kesehatan manusia,
TEO-DEMOKRASI BERBASIS PERTANGGUNGJAWABAN: STUDI KOMPARATIF ATAS RESPONS S.M. ZAFAR DAN MEHDI BAZARGAN TENTANG SISTEM PEMERINTAHAN ISLAM
Authors: Suharto Toto 
Published: June 2023

This article seeks to examine and analyze how the response of two contemporary Islamic thinkers of democracy. Both thinkers are S.M. Zafar and Mehdi Bazargan. They have typical thinking about the system of government. Zafar offers a system of government based on the Theo-democracy parliamentary, because of his opposition to the military system in Pakistan. Whiles Bazargan offers the system of government based on Theo-democracy, because of his opposition to the ‘ulamā’ system of Khomeini’s government. They are looked theo-democracy governance as a system that needs to be implemented in an Islamic state.