bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Graduate School Worth It? Harassment and Graduate-Student Satisfaction in Political Science
Authors: El Kurd Dana , Hummel Calla 
Published: March 2023

ABSTRACTThis article investigates the dynamics of discrimination in political science PhD programs with a survey of current political science graduate students in the top 50 departments. The study focuses on mentorship, funding, sexual harassment, racism, homophobia, and labor exploitation: 20% of respondents reported labor exploitation, 19% experienced racial discrimination, 9% reported sexual harassment, and 6% experienced homophobia. Discrimination is uneven across individuals; some groups of graduate students experience widespread discrimination, especially racial discrimination, whereas other groups are largely unaware of these issues. We conducted a survey experiment to gauge the impact of misconduct on formal reporting mechanisms and find that hearing about racial discrimination has a chilling effect on reporting. We find that experiencing discrimination harms how satisfied students are in their program. We find that factors linked to student vulnerability, such as international status and funding, are significantly associated with harassment and that reporting discrimination predicts more discrimination.
COMPACTNESS AND STRUCTURE OF ZERO-STATES FOR UNORIENTED AVILES–GIGA FUNCTIONALS
Authors: Goldman M. , Merlet B. , Pegon M. , Serfaty S. 
Published: March 2023

AbstractMotivated by some models of pattern formation involving an unoriented director field in the plane, we study a family of unoriented counterparts to the Aviles–Giga functional. We introduce a nonlinear
$\operatorname {\mathrm {curl}}$
operator for such unoriented vector fields as well as a family of even entropies which we call ‘trigonometric entropies’. Using these tools, we show two main theorems which parallel some results in the literature on the classical Aviles–Giga energy. The first is a compactness result for sequences of configurations with uniformly bounded energies. The second is a complete characterization of zero-states, that is, the limit configurations when the energies go to 0. These are Lipschitz continuous away from a locally finite set of points, near which they form either a vortex pattern or a disclination with degree 1/2. The proof is based on a combination of regularity theory together with techniques coming from the study of the Ginzburg–Landau energy. Our methods provide alternative proofs in the classical Aviles–Giga context.
Papeles Seductivos: Friars, Intermediaries, and Organizers in the Huánuco Rebellion of 1812
Authors: Cozzens Taylor 
Published: March 2023

AbstractIn February and March of 1812, Indigenous, mestizo, and creole rebels led an uprising in and around the colonial city of Huánuco in the viceroyalty of Peru. The diversity of the insurgent army reflected, to an extent, the vision of bilingual friars who, in the months preceding the uprising, had written, translated, and distributed pasquinades that called on residents to unite and drive out the Spanish. Although the insurgent army had two initial victories, Spanish authorities quickly put down the movement and began an investigation into the motives and leaders of the rebellion. Their interrogations led them to the subversive friars and the “papeles seductivos” (seductive papers) that these men of the cloth had been circulating. Using a collection of digitized documents from the uprising, which includes several examples of these seditious verses, this paper examines the significance of the Huánuco Rebellion in Peruvian and Latin American history. The rebellion demonstrates the potential of friars in their role as mediators of information to destabilize colonial relations. Additionally, the diverse army of insurgents complicates, at least to a degree, historians’ frequent characterization of Peru in the independence era as a bastion of royalism beset by ethnic tension.
Magnetic Properties of Australasian Tektites From South China
Authors: Pan Qing , Xiao Zhiyong , Wu Yunhua , Shi Taiheng , Yin Zongjun , Yan Pan , Li Ye 
Published: March 2023

AbstractSouth China, the northern part of the Australasian strewn field (AASF) of tektites and microtektites is located at the uprange of the hypothesized source crater that is still unconfirmed. Magnetic properties of impact glasses are an important indicator of their source materials and thermal history. Extensive magnetic investigations have been performed on various AASF tektites sampled from both the Indochina Peninsula and further south, but such information remains sparse for those sampled from South China. Here, we present a detailed rock magnetism study for both Muong Nong‐type and splash‐form AASF tektites from South China, showing that all the tektites have rather weak remanent magnetization, but ferromagnetic information can be extracted from their dominating paramagnetic signal. Signals caused by superparamagnetic particles are elusive, but those of single domain magnetite are detected in the splash‐form tektites, and signals of pseudo‐single domain magnetite are discovered in the Muong Nong‐type tektites. Each morphological type of tektites from a same geographic area exhibits large dispersions in their magnetic properties. Across the entire AASF, the Muong Nong‐type tektites from South China exhibit the lowest average magnetic susceptibility, and the splash‐form tektites exhibit the smallest average natural remanent magnetization and ratio of equivalent magnetization. The observed heterogeneous magnetic properties are mainly caused by the different contents and sizes of magnetic particles, which can be explained by the different shock level and/or cooling history of the tektite melts. Micro‐sized immiscible Fe‐S spherules in the Muong Nong‐type tektites from South China were likely originated from the pre‐impact target.
Drosophila FGFR/Htl signaling shapes embryonic glia to phagocytose apoptotic neurons
Authors: Ayoub Malak , David Li-mor , Shklyar Boris , Hakim-Mishnaevski Ketty , Kurant Estee 
Published: March 2023

AbstractGlial phagocytosis of apoptotic neurons is crucial for development and proper function of the central nervous system. Relying on transmembrane receptors located on their protrusions, phagocytic glia recognize and engulf apoptotic debris. Like vertebrate microglia, Drosophila phagocytic glial cells form an elaborate network in the developing brain to reach and remove apoptotic neurons. However, the mechanisms controlling creation of the branched morphology of these glial cells critical for their phagocytic ability remain unknown. Here, we demonstrate that during early embryogenesis, the Drosophila fibroblast growth factor receptor (FGFR) Heartless (Htl) and its ligand Pyramus are essential in glial cells for the formation of glial extensions, the presence of which strongly affects glial phagocytosis of apoptotic neurons during later stages of embryonic development. Reduction in Htl pathway activity results in shorter lengths and lower complexity of glial branches, thereby disrupting the glial network. Our work thus illuminates the important role Htl signaling plays in glial subcellular morphogenesis and in establishing glial phagocytic ability.
The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei
Authors: Rashpa Ravish , Klages Natacha , Schvartz Domitille , Pasquarello Carla , Brochet Mathieu 
Published: March 2023

AbstractMalaria-causing parasites of the Plasmodium genus undergo multiple developmental phases in the human and the mosquito hosts, regulated by various post-translational modifications. While ubiquitination by multi-component E3 ligases is key to regulate a wide range of cellular processes in eukaryotes, little is known about its role in Plasmodium. Here we show that Plasmodium berghei expresses a conserved SKP1/Cullin1/FBXO1 (SCFFBXO1) complex showing tightly regulated expression and localisation across multiple developmental stages. It is key to cell division for nuclear segregation during schizogony and centrosome partitioning during microgametogenesis. It is additionally required for parasite-specific processes including gamete egress from the host erythrocyte, as well as integrity of the apical and the inner membrane complexes (IMC) in merozoite and ookinete, two structures essential for the dissemination of these motile stages. Ubiquitinomic surveys reveal a large set of proteins ubiquitinated in a FBXO1-dependent manner including proteins important for egress and IMC organisation. We additionally demonstrate an interplay between FBXO1-dependent ubiquitination and phosphorylation via calcium-dependent protein kinase 1. Altogether we show that Plasmodium SCFFBXO1 plays conserved roles in cell division and is also important for parasite-specific processes in the mammalian and mosquito hosts.
Lantern-shaped flexible RNA origami for Smad4 mRNA delivery and growth suppression of colorectal cancer
Authors: Hu Muren , Feng Chang , Yuan Qianqin , Liu Chenbin , Ge Bujun , Sun Fenyong , Zhu Xiaoli 
Published: March 2023

AbstractmRNA delivery has shown high application value in the treatment of various diseases, but its effective delivery is still a major challenge at present. Herein, we propose a lantern-shaped flexible RNA origami for mRNA delivery. The origami is composed of a target mRNA scaffold and only two customized RGD-modified circular RNA staples, which can compress the mRNA into nanoscale and facilitate its endocytosis by cells. In parallel, the flexible structure of the lantern-shaped origami allows large regions of the mRNA to be exposed and translated, exhibiting a good balance between endocytosis and translation efficiency. The application of lantern-shaped flexible RNA origami in the context of the tumor suppressor gene, Smad4 in colorectal cancer models demonstrates promising potential for accurate manipulation of protein levels in in vitro and in vivo settings. This flexible origami strategy provides a competitive delivery method for mRNA-based therapies.
Remnant of the late Permian superplume that generated the Siberian Traps inferred from geomagnetic data
Authors: Li Shiwen , Li Yabin , Zhang Yanhui , Zhou Zikun , Guo Junhao , Weng Aihua 
Published: March 2023

AbstractMantle plumes have played a key role in tectonic events such as continental break-up and large magmatic events since at least the formation of Gondwana. However, as their signatures on Earth’s surface, many of large igneous provinces have disappeared into the mantle during Earth’s long-term evolution, meaning that plume remnants in the mantle are crucial in advancing mantle plume theory and accurately reconstructing Earth history. Here we present an electrical conductivity model for North Asia constructed from geomagnetic data. The model shows a large high-electrical-conductivity anomaly in the mantle transition zone beneath the Siberian Traps at the time of their eruption that we interpret to be a thermal anomaly with trace amounts of melt. This anomaly lies almost directly over an isolated low-seismic-wave-velocity anomaly known as the Perm anomaly. The spatial correlation of our anomaly with the Siberian Traps suggests that it represents a remnant of a superplume that was generated from the Perm anomaly. This plume was responsible for the late Permian Siberian large igneous province. The model strengthens the validity of the mantle plume hypothesis.
FAIRification of health-related data using semantic web technologies in the Swiss Personalized Health Network
Authors: Touré Vasundra , Krauss Philip , Gnodtke Kristin , Buchhorn Jascha , Unni Deepak , Horki Petar , Raisaro Jean Louis , Kalt Katie , Teixeira Daniel , Crameri Katrin , Österle Sabine 
Published: March 2023

AbstractThe Swiss Personalized Health Network (SPHN) is a government-funded initiative developing federated infrastructures for a responsible and efficient secondary use of health data for research purposes in compliance with the FAIR principles (Findable, Accessible, Interoperable and Reusable). We built a common standard infrastructure with a fit-for-purpose strategy to bring together health-related data and ease the work of both data providers to supply data in a standard manner and researchers by enhancing the quality of the collected data. As a result, the SPHN Resource Description Framework (RDF) schema was implemented together with a data ecosystem that encompasses data integration, validation tools, analysis helpers, training and documentation for representing health metadata and data in a consistent manner and reaching nationwide data interoperability goals. Data providers can now efficiently deliver several types of health data in a standardised and interoperable way while a high degree of flexibility is granted for the various demands of individual research projects. Researchers in Switzerland have access to FAIR health data for further use in RDF triplestores.
Ageing in Saudi Arabia: new dimensions and intervention strategies
Authors: Salam Asharaf Abdul 
Published: March 2023

AbstractAgeing process of population passing through demographic dividend in many of the Arab countries, including Saudi Arabia, where the demographic transition process entered a progressive stage. This process has been accelerated with rapid reductions in fertility caused by various changes in the socio-economic and life style dimensions. Researches on population ageing in the country are rare and thus this analytic research aims at exploring population ageing trends at the backdrop of demographic transition to help build up demanded strategies and policies. This analysis explains a rapid native population ageing especially on absolute size: an increase in line with theoretical demographic transition process. Consequently, structural changes in age distribution accompanied a change in age pyramid from an expansive shape of the late 1990s to a constrictive shape in 2010 and further shrinking by 2016. Obviously, various age related indices—age dependency, index of ageing, and median age—exemplify this trend. Still, the old aged population remain static in terms of percentages or indices, exemplifying that the movement of age cohorts continue in the early ages shall reach old age, soon, in this decade: hence, characterizes retirement boom and multiple pathologies compressed to last years of life. Thus, this is an ideal time to prepare for challenges of ageing, learning from the experiences of nations confronted with similar demographic trends. Old aged population deserves care, concern and compassion to ‘add life to years’ with dignity and independence. Informal care mechanisms, especially families, play a vital role on this behalf, and so, deserve to be strengthened and empowered through welfare measures, rather than turning to improving formal care system.
Euryhaline fish larvae ingest more microplastic particles in seawater than in freshwater
Authors: Pratiwi Hilda Mardiana , Takagi Toshiyuki , Rusni Suhaila , Inoue Koji 
Published: March 2023

AbstractMicroplastic (MP) pollution is a major concern in aquatic environments. Many studies have detected MPs in fishes; however, little is known about differences of microplastic uptake by fish in freshwater (FW) and those in seawater (SW), although physiological conditions of fish differ significantly in the two media. In this study, we exposed larvae (21 days post-hatching) ofOryzias javanicus(euryhaline SW) andOryzias latipes(euryhaline FW), to 1-µm polystyrene microspheres in SW and FW for 1, 3, or 7 days, after which, microscopic observation was conducted. MPs were detected in the gastrointestinal tracts in both FW and SW groups, and MP numbers were higher in the SW group in both species. Vertical distribution of MPs in the water, and body sizes of both species exhibited no significant difference between SW and FW. Detection of water containing a fluorescent dye revealed thatO. javanicuslarvae swallowed more water in SW than in FW, as has also been reported forO. latipes. Therefore, MPs are thought to be ingested with water for osmoregulation. These results imply that SW fish ingest more MPs than FW fish when exposed to the same concentration of MPs.
Predicting the eyebrow from the orbit using three-dimensional CT imaging in the application of forensic facial reconstruction and identification
Authors: Kim Yi-Suk , Lee Won-Joon , Yun Ji-Su , Kim Dong-Ho , Lozanoff Scott , Lee U-Young 
Published: March 2023

AbstractEyebrows are the most important facial feature in facial recognition with its shape rated to be more helpful than color or density for facial reconstruction or approximation. However, little extant research has estimated the position and morphological territory of the eyebrow from the orbit. Three-dimensional craniofacial models, produced from CT scans of 180 Koreans autopsied at the National Forensic Service Seoul Institute, were used to conduct metric analyses of subjects (125 males and 55 females) between 19 and 49 (mean 35.1) years. We employed 18 craniofacial landmarks to examine the morphometry of the eyebrow and orbit with 35 pairs of distances per subject measured between landmark and reference planes. Additionally, we used linear regression analyses to predict eyebrow shape from the orbit for every possible combination of variables. The morphology of the orbit has more influence on the position of the superior margin of the eyebrow. In addition, the middle part of the eyebrow was more predictable. The highest point of the eyebrow in female was located more medially than the male. Based on our findings, the equations for estimating the position of the eyebrow from the shape of the orbit is useful information for face reconstruction or approximation.
Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT
Authors: Chen Gefei , Lu Zhonglin , Jiang Han , Lin Ko-Han , Mok Greta S. P. 
Published: March 2023

AbstractPartition model (PM) for Y-90 microsphere radioembolization is limited in providing 3D dosimetrics. Voxel-S-Values (VSV) method has good agreement with Monte Carlo (MC) simulations for 3D absorbed dose conversion. We propose a new VSV method and compare its performance along with PM, MC and other VSV methods for Y-90 RE treatment planning based on Tc-99m MAA SPECT/CT. Twenty Tc-99m-MAA SPECT/CT patient data are retrospectively analyzed. Seven VSV methods are implemented: (1) local energy deposition; (2) liver kernel; (3) liver kernel and lung kernel; (4) liver kernel with density correction (LiKD); (5) liver kernel with center voxel scaling (LiCK); (6) liver kernel and lung kernel with density correction (LiLuKD); (7) proposed liver kernel with center voxel scaling and lung kernel with density correction (LiCKLuKD). Mean absorbed dose and maximum injected activity (MIA) obtained by PM and VSV are evaluated against MC results, and 3D dosimetrics generated by VSV are compared with MC. LiKD, LiCK, LiLuKD and LiCKLuKD have the smallest deviation in normal liver and tumors. LiLuKD and LiCKLuKD have the best performance in lungs. MIAs are similar by all methods. LiCKLuKD could provide MIA consistent with PM, and precise 3D dosimetrics for Y-90 RE treatment planning.
Impact of high altitude on composition and functional profiling of oral microbiome in Indian male population
Authors: Kumari Manisha , Bhushan Brij , Eslavath Malleswara Rao , Srivastava Ashish Kumar , Meena Ramesh Chand , Varshney Rajeev , Ganju Lilly 
Published: March 2023

AbstractThe oral cavity of human contains bacteria that are critical for maintaining the homeostasis of the body. External stressors such as high altitude (HA) and low oxygen affect the human gut, skin and oral microbiome. However, compared to the human gut and skin microbiome, studies demonstrating the impact of altitude on human oral microbiota are currently scarce. Alterations in the oral microbiome have been reported to be associated with various periodontal diseases. In light of the increased occurrence of HA oral health related problems, the effect of HA on the oral salivary microbiome was investigated. We conducted a pilot study in 16 male subjects at two different heights i.e., H1 (210 m) and H2 (4420 m). Total of 31 saliva samples,16 at H1 and 15 at H2 were analyzed by utilizing the 16S rRNA high-throughput sequencing, to explore the relationship between the HA environment and salivary microbiota. The preliminary results suggesting that, the most abundant microbiome at the phylum level are: Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria. Interestingly, 11 genera were identified at the both heights with different relative abundances. In addition, the salivary microbiome was more diverse at H1 compared to H2 as demonstrated by decreased alpha diversity. Further, predicted functional results indicate that microbial metabolic profiles significantly decreased at H2 as compared to H1, including two major metabolic pathways involving carbohydrates, and amino acids. Our findings show that HA induces shifts in the composition and structure of human oral microbiota which can affect host health homeostasis.
Highly reconfigurable oscillator-based Ising Machine through quasiperiodic modulation of coupling strength
Authors: Albertsson Dagur I. , Rusu Ana 
Published: March 2023

AbstractIsing Machines (IMs) have the potential to outperform conventional Von-Neuman architectures in notoriously difficult optimization problems. Various IM implementations have been proposed based on quantum, optical, digital and analog CMOS, as well as emerging technologies. Networks of coupled electronic oscillators have recently been shown to exhibit characteristics required for implementing IMs. However, for this approach to successfully solve complex optimization problems, a highly reconfigurable implementation is needed. In this work, the possibility of implementing highly reconfigurable oscillator-based IMs is explored. An implementation based on quasiperiodically modulated coupling strength through a common medium is proposed and its potential is demonstrated through numerical simulations. Moreover, a proof-of-concept implementation based on CMOS coupled ring oscillators is proposed and its functionality is demonstrated. Simulation results show that our proposed architecture can consistently find the Max-Cut solution and demonstrate the potential to greatly simplify the physical implementation of highly reconfigurable oscillator-based IMs.