bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of atmospheric deposition in the territory of the Republic of North Ossetia-Alania by biomonitoring data
Authors: Kamanina I. Z. , Kaplina S. P. , Gustova M. V. , Chigoeva Dz. N. , Vinogradov I. I. 
Published: March 2023

Attention to the tourism potential of the Republic of North Ossetia-Alania is increasing with the attendant need to monitor and control atmospheric air pollution.Aim. The assessment of the possibility of using mosses as biomonitors for determining the content of heavy metals and other trace elements in the atmosphere of the territory of the Republic of North Ossetia-Alania.Material and Methods. The green mosses Hylocomium splendens and Pleurosium schreberi were used as bioindicators. Multi-element chemical analysis of mosses was carried out using X-ray fluorescence and the morphology and composition of dust fallouts on the moss surfaces was studied using a scanning electron microscope equipped with an X-ray energy-dispersive spectrometer.Results. The maximum concentration of Pb, Zn, Cr, As, Sn, Sb, Ba, Cd, Cu, Ti, Ce, As, Fe, Sr is observed in mosses in areas of the territory with a high aerotechnogenic load. The analysis of biomonitor moss in the area of the Fiagdonna tailing dump indicates that recultivation measures had been effective. Toxic elements fall on moss surface in form of fine particles as large as 1 micron and pose a danger to human health.Conclusions. The abnormally high content of Zn, Pb, Cd, Cu, Ce, As, Fe, Sr, Ti, Ba in the composition of biomonitor mosses was registered in the zone of influence of mining and processing enterprises (in the area of the Unal tailings dump) and metallurgical industries in Vladikavkaz (JSC Electrozinc and JSC Pobedit. The base source of toxic elements was determined to be fine aerotechnogenic particles that accumulate on the surface of mosses, thus confirming the high efficiency of their use for monitoring. The territory near the village of Dur Dur can be recommended as a background for ecological and geochemical research.
Transformation of Water Consumption and Sanitation in the Russian Part of the Transboundary Ural River Basin
Authors: Demin A. P. 
Published: March 2023

Aim. Study of the transformation of water consumption and wastewater disposal in the Russian part of the Ural River basin. Ural in 1995-2020 due to changing socio-economic and technological conditions.Materials and Methods. The data of state statistical reporting (form 2-TP (vodkhoz)) for the period 1995-2020 were used. Materials of the AllRussian Agricultural Census of 2016, collections of the Ministry of Agriculture of the Russian Federation, "Agro-industrial Complex of Russia", on the commissioning of irrigated lands, the regional Department of Land Reclamation and reports on the state and environmental protection for the constituent entities of the Russian Federation were consulted. The study was carried out on the basis of a systematic approach using the following methods: (1) analytical (collection and systematization of primary information); (2) special (tables compiled, charts constructed; (3) statistical data processing and comparative analysis.Results. It was revealed that from 1995 to 2020 water intake in the Russian part of the Ural River basin to meet the needs of the population and the economy was reduced by 2.4 times. The average daily specific water consumption per 1 inhabitant has decreased in all regions. The water cycle coefficient in the basin increased from 73 to 88%. In recent years, an increase in the area of irrigated land has begun.Conclusion. There has been a noticeable reduction in water consumption and wastewater disposal in the Russian part of the Ural River basin. This is mainly due to the decline in industrial and agricultural production, as well as the development of circulating water supply in industry and the introduction of water-saving equipment in housing and communal services.
Comparación de las características anatómicas del conducto nasopalatino en pacientes dentados y desdentados mediante tomografía computarizada de haz cónico. Lima 2018-2020
Authors: Chacón de Velasco Sheyla Fiorella , Ruiz García de  Chacon Vilma Elizabeth , Sotelo Chavez Aldo Grimaldo 
Published: March 2023

Objetivo: Comparar las características anatómicas del CNP en pacientes dentados y desdentados mediante Tomografía Computarizada de Haz Cónico (TCHC) del Servicio de Radiología Bucomaxilofacial realizadas en el Centro Dental Docente de la Universidad Peruana Cayetano Heredia. Material y métodos: Se evaluaron todas las TCHC adquiridas entre los años 2018 y 2020, que cumplan con ciertos criterios; donde se comparó las características anatómicas del CNP. Los datos fueron registrados en una base de datos, luego representados en tablas. Resultados: Se evaluaron 216 volúmenes tomográficos (VT), divididos en dos grupos: dentados y desdentados. La forma cilíndrica y la forma de canal único fueron las más encontradas en ambos grupos. La longitud y la distancia fueron mayores en pacientes dentados, no se encontró asociación con relación al diámetro; la inclinación fue mayor en pacientes desdentados, encontrándose asociación con relación a la inclinación entre los grupos comparados. Conclusiones: Se encontraron múltiples diferencias anatómicas del CNP entre los pacientes dentados y desdentados evaluados con TCHC con relación al sexo y la edad.
Tratamiento estético de la sonrisa gingival
Authors: Padilla-Avalos César-Augusto , Marroquín-Soto Consuelo 
Published: March 2023

La exposición gingival excesiva es una condición conocida como sonrisa gingival. Esta alteración genera en muchos casos insatisfacción y solicitud de tratamiento por parte de los pacientes. Este exceso de exposición gingival podría obedecer a diferentes etiologías como un exceso maxilar en sentido vertical, un labio superior corto e hipermóvil, la erupción pasiva alterada, la extrusión dentoalveolar en el sector anterior o la combinación de estas causas. El enfoque de tratamiento va a depender del diagnóstico, de la complejidad del caso y de las expectativas de cada paciente. Por lo tanto, las rutas terapéuticas principales son el alargamiento de corona clínica, el reposicionamiento labial, la cirugía ortognática o la aplicación de toxina botulínica. Para ello, se debe considerar las ventajas y limitaciones de cada tratamiento estético, para garantizar predictibilidad y éxito.
Analysis of Spatial Working Memory Using the Y-Maze on Rodents Treated with High-Calorie Diet and Moderate-Intensity Exercise
Authors: Melbiarta Rezy Ramawan , Kalanjati Viskasari P. , Herawati Lilik , Salim Yusuf , Othman Zulhabri 
Published: March 2023

Highlights:

This article reports the use of the Y-maze as a simple yet effective method to measure spatial working memory in mice.
The Y-maze method can be used safely without exposing the animals to additional stressors, as evidenced by the absence of mortality following the test.

Abstract:
Spatial working memory (SWM) in humans and animal models with impaired cognitive functions has been analyzed through a number of methods. However, this is still understudied in animal models treated with a high-calorie diet (HCD) and moderate-intensity exercise (MIE). The Y-maze was utilized as the assessment method in this study. A 40 x 9 x 9 cm3 Y-maze was employed to observe the animal models’ spontaneous alternation (SA) as the representation of their SWM. This was done by calculating the total alternation percentage divided by total entry minus two. A total of 17 female Mus musculus mice aged 8 weeks were tested in the Y-maze to investigate their SWM using SA calculations. Each mouse was analyzed for eight minutes and recorded in a dark and quiet room to minimize bias due to environmental noise and lighting. Comparing the treatment group’s (HCD+MIE) SA to the control group’s SA revealed no statistically significant difference (p=0.451). Seven mice in the treatment group performed similarly to the mice in the control group in the Y-maze test, with no significant difference in their ability to complete the task. The mice in the treatment group exhibited no motor impairment, as indicated by complete movements of all their extremities while exploring the Y-maze within the allotted time. In conclusion, the Y-maze can be used as a reliable method to analyze SWM in overweight/obese Mus musculus animal models treated with moderate-intensity physical exercise.
Mortality among Heart Failure Patients in the Presence of Cachexia
Authors: Andrianto  , Karman Ula Nur Pramesti , Mudjanarko Sony Wibisono , Ardiana Meity , Hermawan Hanestya Oky 
Published: March 2023

Highlights:

Around 38.8% of heart failure patients with cachexia died during the 180-1,876-day follow-up period.
Cachexia increases the risk of mortality in heart failure patients.

Abstract:
Despite the fact that obesity has long been recognized as a risk factor for cardiovascular disease, the mortality rate of heart failure (HF) patients with cachexia is still high. Several studies have been conducted to investigate the association between cachexia and mortality in HF patients. However, the research results vary, as do the diagnostic criteria employed to assess cachexia. This meta-analysis aimed to conclusively summarize the association between cachexia and mortality in HF patients. The data were obtained from prospective or retrospective cohort studies with full texts in English or Indonesian and keywords related to "cachexia," "heart failure," and/ or "mortality". Studies that did not assess mortality in HF patients with cachexia and had no full text accessible were omitted. A literature search was conducted through four databases (PubMed, Web of Science, Scopus, and SAGE Journals) using keywords, reference searches, and/ or other methods on April 2022 in accordance with the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data from the selected studies were presented and analyzed using qualitative and quantitative synthesis methods. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias in the selected cohort studies. The qualitative synthesis contained nine studies, whereas the quantitative synthesis (meta-analysis) included six studies. Cachexia was found in 16.0% of the 4,697 patients studied. During the 180-1,876-day follow-up period, 33.0% of the patients died, with a mortality rate of 38.8% among the patients with cachexia. The pooled analysis revealed cachexia to be a significant predictor of mortality in HF patients (hazard ratio (HR)=3.84; 95% CI=2.28-6.45; p<0.00001), but with significant heterogeneity (p<0.00001; I2=88%). In conclusion, cachexia worsens HF prognosis.
Disfunções olfativas e gustativas provocadas por COVID-19: revisão integrativa da literatura
Authors: Costa Nicolas Gustavo Souza , Silva Raiza Lima , Vale Mariana Lima 
Published: March 2023

Objetivo: Apresentar uma revisão integrativa da literatura acerca dos mecanismos fisiopatológicos que promovem distúrbios neurológicos na COVID-19, em especial anosmia e disgeusia. Metodologia: Uma revisão integrativa foi realizada a partir de uma busca nas bases de dados Pubmed e Scopus utilizando os descritores “Dysgeusia”, “Olfaction Disorders” e “Coronavirus Infections”, integrados pelo operador booleano “AND”. Além disso, efetuou-se uma busca manual nas referências de estudos relevantes. Resultados: Analisou-se um total de 41 artigos na íntegra, dos quais 20 foram incluídos no trabalho. Percebeu-se hipóteses de associação de anosmia e disgeusia com lesão direta ao neuroepitélio olfatório e na mucosa oral, vias neurotrópicas de danos ao sistema nervoso central, processos inflamatórios neurogênicos e prejuízos na atividade de neurotransmissores envolvidos na transdução do paladar. Conclusão: Distúrbios no paladar e no olfato são sintomas que devem ser considerados relevantes na patogênese da COVID-19 e ainda demandam estudos subsequentes, visto a importância dos diferentes mecanismos e vias fisiopatológicas.
Palavras-chave: Coronavírus. Disgeusia. Anosmia. Neurologia.
Developing the Islamic Reading Center Through Fostering the Village Youth Organization to Improve Children’s Literacy
Authors: Wardhani Irma Yuniar , Fakhri Auliya Nanang Nabhar , Fuadah Laily 
Published: March 2023

The study of literacy always becomes the main issue in education, because this skill is a benchmark for the progress and development of a nation. Indonesia is a large country with a large area, however with its wide area it turns out to be an obstacle in terms of equalizing education in Indonesia. In fact, some rural villages have not had adequate access to education and it causes the paradigm about education among rural villages is less open. Moreover, Indonesia is a country which majority of the population are Muslims, so the literacy skills improvement program which is being pursued should have an Islamic value. . Unfortunately, there have not been many reviews about increasing literacy skills based on Islamic education. Therefore, it needs an effort that can develop literacy skills for children especially for the nation's next generation. The fostering of villages youth organizations through the Islamic Reading Center (IRC) which aims to increase children's literacy is a literacy collaborative (LC) program starting from rural villages’ level, local government and central government which involves youth organization from the rural villages’ level, sub-district, regency, education and culture agency, social agency, regional and national libraries, and the directorate general of Islamic education of religious ministry of Republic of Indonesia. The Islamic reading center provides Islamic books and media that can be managed by the youth organizations in a rural village. So, through Islamic reading centers and literacy activities, it can increase literacy skills in rural villages which need more attention in education.
Study on performance Evaluation of CMOS Inverter using Surrounded channel Junctionless Field Effect Transistor
Authors: Das Namita , Sarma Kaushik Chandra Deva 
Published: March 2023

Abstract
The paper present here analyses the modeling and performance of CMOS inverters using surrounded channel Junction less field effect transistor (SCJLFET). A mathematical model for different parameters like low input voltage and high input voltage, low output voltage and high output voltage, power dissipation, noise margin, rise time, fall time, propagation delay of the CMOS inverter circuit has been established. To design the model for various parameters, potential models at the channel source boundary and the potential at the channel drain boundary are considered. The variations in the voltage transfer characteristics, output current and the power dissipation with respect to the input voltage for steady-state conditions and transient states were evaluated for different gate dielectrics, gap lengths and gate oxide thicknesses. The models were compared with technology computer aided design (TCAD) simulation results for validation. The noise margin, rise time, fall time and propagation delay of the SCJLFET based Complementary metal oxide semiconductor (CMOS) inverter is evaluated and compared with those of a conventional junction less transistor. It has been observed that the SCJLFET exhibits an improvement in the noise margin and propagation delay compared with conventional junction less transistors.
Point and interval prediction of carbon price: A novel hybrid model considering the severe volatility and the complexity
Authors: Ding Lili , Zhao Haoran , LI Hui 
Published: March 2023

Abstract
The development of global economic suffers from the serious problem of carbon emission. Accurate carbon price prediction is of great significance for carbon emission reduction. However, it is difficult for the existing carbon price prediction model to simultaneously solve the severe volatility and the complexity of carbon price. Therefore, this paper proposes a novel hybrid model composed of econometric model, machine learning model and optimization algorithm to realize point and interval prediction of carbon price. In the proposed model, an adaptive variational mode decomposition algorithm is proposed to explore the characteristics of carbon price sub-series. In point prediction, different from previous studies, this paper uses unsupervised clustering to distinguish the different complexity of the intrinsic modal functions. The high complexity components are predicted by BP neural network based on war strategy optimization algorithm, and the low complexity components are predicted by econometric model, which improves the prediction accuracy and the interpretability of the model. In interval prediction, the paper uses kernel density estimation and nonparametric bootstrap to obtain the probability distribution of the predicted value, and makes interval prediction according to different significance levels, which can provide more reliable information for decision-making. According to the empirical results of China’s Shenzhen carbon trading market and Beijing carbon trading market, our proposed model is superior to the other 23 benchmark models in point prediction and can perform effective interval prediction.
Statistical mining of triple-negative breast cancer-specific nanobodies among huge libraries from immunized alpacas
Authors: Maeda Ryota , Yamazaki Hiroyuki , Kobayashi Ryoga , Yamamoto Seishiro , Kasai Kazuki , Imura Akihiro 
Published: March 2023

Abstract
Breast cancer can be classified into several types according to the expression patterns of human epidermal growth factor receptor 2 (Her2), oestrogen receptor (ER), and progesterone receptor (PgR) proteins. The prognosis of patients with tumors showing low Her2 expression and no ER and PgR expression—categorized as triple-negative breast cancer (TNBC)—is worst among these groups. Due to the lack of specific antibodies for TNBC, curative treatments for TNBC remain limited. Antibodies targeting TNBC have potential as diagnostic and therapeutic tools. Here, we generate a panel of nanobodies targeting TNBC cell lines by immunizing alpacas and subsequently panning the resulting phage libraries with TNBC cell lines. We show that several clones exclusively stain Her2-negative cells in tissues of breast cancer patients, and a few clones stain both Her2-positive and Her2-negative regions in these tissues. These clones can be applied to patient-specific therapies using drug-conjugated antibodies, radiolabelled antibodies, chimaera antigen receptor T cells, or drug delivery components, as well as to TNBC diagnosis.
Exploration of the mechanisms of Cyperi Rhizoma in the treatment of endometriosis through GEO datasets, network pharmacology, and molecular docking studies
Authors: Fang Xingyi , Gong Yi , Li Jinjing , Jin Yanbin , Limeng Yongwei , Ma Yanlin , Huang Yuanhua 
Published: March 2023

Abstract

Cyperi rhizoma (CR) has traditionally been used to treat endometriosis (EMS), but its molecular mechanism remains unclear. To address this, we used a multi-faceted approach that included analysis of GEO datasets, network pharmacology, molecular docking and in vitro experiments.CR components and their potential targets were identified using TCMSP and PubChem, while GEO datasets, GeneCards, and DisGeNET were used to retrieve EMS-related targets. Compound-target and protein-protein interaction networks were constructed using Cytoscape and STRING, respectively, and hub genes were identified using CytoHubba. Enrichment analysis and molecular docking were performed, and RT-qPCR and Western blotting were used to assess protein expression levels. According to our research, there are 18 active CR components and 34 possible anti-EMS targets. Network analysis identified quercetin and kaempferol as potential key chemicals and revealed IL6, MMP9, CCL2, CXCL8, ICAM1, L10, VCAM1, IL18, SELE and TIMP1 as central hub genes in the network. GO, KEGG and GSEA analyses showed that ICAM1 and VCAM1 are involved in "positive regulation of cell adhesion", TNF signalling pathway, NF-kappa B signalling pathway and "GO_INFLAMMATORY_RESPONSE". Analysis of the GEO datasets revealed that ICAM1 and VCAM1 were upregulated in endometriosis compared to controls. Molecular docking showed that quercetin and kaempferol have strong binding affinities for these proteins. RT-qPCR and Western blotting analyses showed that CR treatment suppressed ICAM1 and VCAM1 expression, leading to reduced inflammation and adhesion in endometriosis-associated symptoms. Thus, these results provide a novel rationale for the potential of CR in the treatment of EMS.
Influence of radiotherapy on the physical-mechanical properties of different pit and fissure sealants
Authors: Marubayashi Lucas Masaru , Galo Rodrigo , Barbosa Paulla Iáddia Zarpellon , Oliveira Harley Francisco de Oliveira , Tores Carolina Paes , de Queiroz Alexandra Mussolino , Borsatto Maria Cristina 
Published: March 2023

Abstract
Objectives: This study was to evaluate whether ionizing radiation used in the treatment of Head and Neck Cancer interferes with the adhesion of pit and fissure sealants applied to tooth enamel.
Materials and Methods: A total of 105 healthy human teeth were randomly allocated between the control group (non-irradiated teeth) and irradiated groups subdivided into pre-radiotherapy and post-radiotherapy. The teeth were treated using a resin sealant (Fluoroshield®) or a cement of conventional glass ionomer (Ketac Molar Easymix®). The conventional radiotherapy protocol consisted of applying an irradiation dose of 2Gy per day, over a period of 35 days, totaling a cumulative dose of 70Gy. Marginal microleakage test (n=60 teeth) and shear test (n=45 teeth) were performed. Data statistical analysis considered a significance value of 5%.
Results: Both in the shear test and the microleakage test, the resin sealant presented the best results. Also, there was no statistically significant difference in any of the tests between the non-irradiated groups and groups that received radiotherapy.
Conclusions: Thus, radiotherapy does not influence the adhesion of pit and fissure sealants of the different materials used, and the resin sealant presented better performance when compared to the conventional glass ionomer. Clinical relevance: of this study lies in the fact that patients undergoing radiotherapy treatment can undergo preventive treatment with sealants before or after radiotherapy, with resinous materials being the most suitable for this condition.
Transvaginal Posterior Levatorplasty and Perineoplasty for female Primary Stress Urinary Incontinence: 12-month follow-up and technical presentation
Authors: Xu Yansheng , Wei Lan , Liu Meichen , Jia Zhuomin , Li Yilin , Li Fengyong 
Published: March 2023

Abstract
The levator ani (LA) plays key roles in maintaining continence during sudden increase of intraabodominal pressure. To date, there has been no reports on the treatment of female stress urinary incontinence (SUI) by repairing the LA. We aimed to investigate the feasibility of transvaginal posterior levatorplasty combined with perineoplasty (TPLP) for women with primary stress urinary incontinence and demonstrate the surgical technique with step-by-step procedures. A total of 47 patients were prospectively enrolled in this study with a mean age of 43.6 years. Mean operative time was 78.7minites. Median estimated intraoperative blood loss was 80.2 ml. Objective cure and subjective cure rates were 87.2% and 91.5%, respectively. Compared with baseline, scores of quality of life，symptom severity and sexual function improved after surgery. Meanwhile, mobility of the urethra and bladder neck and areas of levator hiatus were decreased after surgery. There was no major adverse event, except mild coitus pain was reported in 15.4% (6/39) patients at the initial several times of intercourse after resuming sexual activity. In conclusions，this study shows that TPLP appears to be an effective surgical method for selected women with primary stress urinary incontinence.