bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volumetric assessment of individual thalamic nuclei in patients with drug-naïve, first-episode major depressive disorder
Authors: Chibaatar Enkhmurun , Watanabe Keita , Okamoto Naomichi , Orkhonselenge Nasanbadrakh , Natsuyama Tomoya , Hayakawa Gaku , Ikenouchi Atsuko , Kakeda Shingo , Yoshimura Reiji 
Published: March 2023

IntroductionDespite the previous inconsistent findings of structural and functional abnormalities of the thalamus in patients with major depressive disorder (MDD), the disruption of the thalamic nuclei in the pathophysiology of this disorder has not yet been adequately studied. Therefore, we investigated the volumetric changes of thalamic subregions and their nuclei in drug-naïve, first-episode MDD patients. We also investigated the association between HAM-D scores, a clinical scale frequently used to evaluate the severity of depression and thalamic nuclei volumes in MDD patients.MethodsThis study included 76 drug-naïve MDD patients and an equal number of healthy subjects. Magnetic resonance imaging (MRI) data were obtained using a 3T MR system and thalamic nuclei volumes were evaluated using FreeSurfer ver.7.11. The volumetric differences were compared by one-way analysis of covariance (ANCOVA) and to ensure that effects were not accounted for by other factors, age, sex, and ETICV variables were included as covariates.ResultsWe observed significant volume reductions of the left whole thalamus (p &lt; 0.003) and several thalamic nuclei mostly on the left side in the MDD group compared with healthy controls (HCs). Furthermore, we have revealed weak negative correlations between several thalamic nuclei volumes and HAM-D total and subscale scores.DiscussionThis is the first research study to investigate alterations of the various thalamic nuclei volumes in MDD patients compared with HCs. Moreover, we first analyzed the association between individual thalamic nuclei volumes and HAM-D subscale scores. Though our study may be restricted at certain levels, especially by the demographic difference between the two groups, they possibly contribute at a preliminary level to understanding the thalamic structural changes at its subregions in patients with drug-naïve, first-episode MDD.
Fungal infections in pediatric patients with acute myeloid leukemia in a tertiary hospital
Authors: Ávila Montiel Diana , Saucedo Campos Alberto , Avilés Robles Martha , Murillo Maldonado Marco Antonio , Jiménez Juárez Rodolfo , Silva Dirzo Marisol , Dorantes Acosta Elisa 
Published: March 2023

IntroductionAcute leukemia accounts for more than 30% of all pediatric cancer cases, and of these, 15–20% are acute myeloid leukemia (AML). Children who super from AML are more likely to develop infections due to the humoral and cellular immune deficits generated by the disease and its treatment. The incidence of fungal infections is underestimated; reports show that up to 75% of fungal infections go undiagnosed until autopsy. In only 30 years, the incidence of invasive candidiasis has increased by 40-fold. Thus, the high morbidity and mortality associated with fungal infections in hematological patients make it necessary to adopt preventive measures.MethodsThis work aimed to retrospectively identify pediatric patients with acute myeloid leukemia and invasive fungal diseases (IFDs) in a Latin American tertiary care hospital. A retrospective analysis of 36 clinical records of pediatric patients diagnosed with AML from 2007 to 2017 was carried out.ResultsOne hundred and twenty-nine hospitalizations were associated with infectious events. Thirteen patients in our study presented 15 infectious events associated with IFDs (11.6%). Two patients died because of complications related to IFDs (15.3%). The most frequent IFD type was aspergillosis, which was observed in 7 cases, followed by Candidemia, which was observed in 4 cases. The most frequent clinical manifestations were fever and respiratory distress.DiscussionMortality due to IFD can be prevented with effective pharmacotherapy. An appropriate antifungal prophylaxis strategy still needs to be developed through larger prospective studies in Latin America.
Workplace aggression against healthcare workers in a Spanish healthcare institution between 2019 and 2021: The impact of the COVID-19 pandemic
Authors: Díaz Aitor , Utzet Mireia , Mirabent Joan , Diaz Pilar , Ramada Jose Maria , Serra Consol , Benavides Fernando G. 
Published: March 2023

ObjectivesDescribe the incidence of first aggressions among healthcare workers (HCWs) before and during the COVID-19 pandemic in a Spanish healthcare institution, according to workers' socio-occupational characteristics and analyze the impact of the pandemic on it.MethodsA cohort involving HCWs who worked in the institution for at least 1 week each year from 1 January 2019 to 31 December 2021. Adjusted relative risks (aRR) were estimated using generalized estimating equations and negative binomial models to calculate the differences in WPA between the different time periods. All analyses were stratified by gender.ResultsAmong women, the incidence was 6.8% (6.0; 7.8) during the pre-COVID-19 period, 6.0% (5.2; 7.0) during the COVID-19 baseline and 5.1% (4.3; 5.9) during the COVID-19 endline; and 4.6% (3.4; 6.1), 5.3% (4.1; 6.8) and 4.4% (3.5; 5.8), respectively, among men. Among men, the incidence of WPA was 4.6 (3.4; 6.1), 5.3 (4.1; 6.8), and 4.4% (3.5; 5.8), respectively. These incidences were significantly higher among male nurses and aides [11.1 (8.0; 15.4), 12.3 (8.9; 16.6), and 9.3% (6.5; 13.3) during each period] and psychiatric center workers [women: 14.7 (11.2; 19.0), 15.4 (11.8; 19.8), and 12.4% (9.2; 16.6); men: 12.3 (7.2; 20.0), 17.8 (11.6; 26.2), and 14.3% (8.8; 22.4)]. Among women, the risk of WPA was 23% lower in the post-COVID-19 period compared to before the pandemic [aRR = 0.77 (0.64; 0.93)], while the risk during the COVID-19 baseline was not significantly different [aRR = 0.89 (0.74; 1.06)].ConclusionsThe COVID-19 pandemic led to an unexpected decrease in first-time WPA against HCWs. However, ~5% of HCWs experienced at least one incidence of aggression in the last follow-up year. Healthcare managers should continue to increase the prevention of aggression against HCWs, especially among vulnerable groups with a higher level of incidence.
The alternate-form reliability study of six variants of the Brief Visual-Spatial Memory Test-Revised and the Hopkins Verbal Learning Test-Revised
Authors: Cai Yumei , Yang Tianlong , Yu Xin , Han Xue , Chen Gong , Shi Chuan 
Published: March 2023

IntroductionThe revised Hopkins Verbal Learning Test-Revised (HVLT-R) and the Brief Visual-Spatial Memory Test-Revised (BVMT-R) are two widely used test involving verbal and visual learning and memory. In the two tests, six different versions are assembled, respectively, to prevent learning effects. Currently, no researchers have compared the six versions of the two tests. Thus, their usefulness in clinical studies requiring multiple follow-ups is limited. In this work, we confirm the equivalence of six HVLT-R and BVMT-R versions.Methods20 people completed all six HVLT-R and BVMT-R versions, while 120 people were randomly assigned to complete one of the six versions of each test. The Intelligence Quotient (IQ) level is measured using the short version of the Wechsler Adult Intelligence test. R4.2.0 is used for statistical analysis. The K-Related sample test (a non-parametric test) is used to observe the differences in test scores among the 20 subjects. The one-way Analysis of Variance (ANOVA) test is utilized to analyze the differences in test scores among the 120 subjects. The scores on different versions are compared using two similar sample tests. The HVLT-R Total Learning, the HVLT-R Delayed Recall, the BVMT-R Total Learning, and the BVMT-R Delayed Recall are indexes for comparison. Version and test scores are used as research factors, while different versions are used as research levels.ResultsThe results suggest that HVLT-R and BVMT-R versions 3, 5 and 6 are equally difficult, and relatively easy compared to versions 1, 2 and 4. HVLT-R versions 3, 5, and 6 show good reliability and can be used interchangeably when testing word learning ability or short-term memory; BVMT-R Versions 3, 5, and 6 show acceptable reliability and can be can be used interchangeably.DiscussionIn the study of multiple follow-ups, it is a must to avoid discrepant versions and choose other equivalent versions. The results from this study could be used as a guide for upcoming studies and clinical applications in China.
Assessing the impact of urban greenspace on physical health: An empirical study from Southwest China
Authors: Seyler Barnabas C. , Luo Han , Wang Xiuli , Zuoqiu Sophia , Xie Yao , Wang Yuan 
Published: March 2023

IntroductionAs the world becomes increasingly urbanized and human-nature contact declines, urban greenspace's impact on human health has garnered growing interest across academic disciplines. Various definitions and multiple indicators of greenspace have been utilized, with most studies finding an overall positive association between greenspace and health. Nevertheless, studies directly comparing how different greenspace indicators impact different disease types have been limited. Moreover, to verify the robustness of conclusions drawn, studies should compare multiple measures of greenspace across various spatial scales. Thus, a more comprehensive analysis is necessary to help inform future study design, especially in determining which greenspace indicators would be most useful in data-limited areas.MethodsChengdu, the capital city of Sichuan Province, is West China's largest and most urban city, being typical of other large cities in lower to middle-income countries (LMICs). With twenty county-level jurisdictions spanning various degrees of urbanization, Chengdu's landscape heterogeneity and large population make it ideal for studying greenspace's impact on public health. This study took Chengdu as a case study to assess the association and potential impact of three traditional measures of greenspace (Normalized Difference Vegetation Index, Enhanced Vegetation Index, and Fractional Vegetation Cover) and urban ratio (% of population being urban) on hospitalization rates and medical expenses paid for three major disease categories (circulatory system diseases, neoplasms, and respiratory system diseases).Results and discussionWe found greenspace did have a significant impact on public health, but this relationship differed by disease type. Greenspace exhibited significant positive association with respiratory diseases, but insignificant negative associations with the other disease categories. Urban ratio showed significant negative association with greenspace abundance. The higher the urban ratio (e.g., less greenspace), the more money was paid on medical expenses. This relationship was found not only in terms of urban ratio being positively correlated with medical expenses, but also in that all three greenspace indicators were negatively correlated with medical expenses. Consequently, in future health outcome studies, urban ratio could be an acceptable negative indicator of greenness in LMICs where urban ratio is likely to imply less greenness.
Hand rehabilitation based on the RobHand exoskeleton in stroke patients: A case series study
Authors: Barria Patricio , Riquelme Matías , Reppich Hannah , Cisnal Ana , Fraile Juan-Carlos , Pérez-Turiel Javier , Sierra David , Aguilar Rolando , Andrade Asterio , Nuñez-Espinosa Cristian 
Published: March 2023

Introduction: The RobHand (Robot for Hand Rehabilitation) is a robotic neuromotor rehabilitation exoskeleton that assists in performing flexion and extension movements of the fingers. The present case study assesses changes in manual function and hand muscle strength of four selected stroke patients after completion of an established training program. In addition, safety and user satisfaction are also evaluated.Methods: The training program consisted of 16 sessions; two 60-minute training sessions per week for eight consecutive weeks. During each session, patients moved through six consecutive rehabilitation stages using the RobHand. Manual function assessments were applied before and after the training program and safety tests were carried out after each session. A user evaluation questionnaire was filled out after each patient completed the program.Results: The safety test showed the absence of significant adverse events, such as skin lesions or fatigue. An average score of 4 out of 5 was obtained on the Quebec User Evaluation of Satisfaction with Assistive Technology 2.0 Scale. Users were very satisfied with the weight, comfort, and quality of professional services. A Kruskal-Wallis test revealed that there were not statistically significant changes in the manual function tests between the beginning and the end of the training program.Discussion: It can be concluded that the RobHand is a safe rehabilitation technology and users were satisfied with the system. No statistically significant differences in manual function were found. This could be due to the high influence of the stroke stage on motor recovery since the study was performed with chronic patients. Hence, future studies should evaluate the rehabilitation effectiveness of the repetitive use of the RobHand exoskeleton on subacute patients.Clinical Trial Registration:https://clinicaltrials.gov/ct2/show/NCT05598892?id=NCT05598892&amp;draw=2&amp;rank=1, identifier NCT05598892.
An Accurate Activate Screw Detection Method for Automatic Electric Vehicle Battery Disassembly
Authors: Li Huaicheng , Zhang Hengwei , Zhang Yisheng , Zhang Shengmin , Peng Yanlong , Wang Zhigang , Song Huawei , Chen Ming 
Published: March 2023

With the increasing popularity of electric vehicles, the number of end-of-life (EOF) electric vehicle batteries (EVBs) is also increasing day by day. Efficient dismantling and recycling of EVBs are essential to ensure environmental protection. There are many types of EVBs with complex structures, and the current automatic dismantling line is immature and lacks corresponding dismantling equipment. This makes it difficult for some small parts to be disassembled precisely. Screws are used extensively in batteries to fix or connect modules in EVBs. However, due to the small size of screws and differences in installation angles, screw detection is a very challenging task and a significant obstacle to automatic EVBs disassembly. This research proposes a systematic method to complete screw detection called “Active Screw Detection”. The experimental results show that with the YOLOX-s model, the improved YOLOX model achieves 95.92% and 92.14% accuracy for both mAP50 and mAP75 positioning after autonomous adjustment of the robotic arm attitude. Compared to the method without autonomous adjustment of the robotic arm, mAP50 and mAP75 improved by 62.81% and 57.67%, respectively. In addition, the improved YOLOX model improves mAP50 and mAP75 by 0.19% and 3.59%, respectively, compared to the original YOLOX model.
Three-Dimensional Sulfated Bacterial Cellulose/Gelatin Composite Scaffolds for Culturing Hepatocytes
Authors: Li Xinmeng , Ding Weixiao , Wang Shujun , Yang Luyu , Yu Qingqing , Xiao Changji , Chen Guangbo , Zhang Lei , Guan Shanyue , Sun Dongping 
Published: March 2023

The liver is the hub of human metabolism and involves many diseases. To better work on the mechanism and treatment of liver diseases, it is of particular interest to design 3-dimensional scaffolds suitable for culturing hepatocytes in vitro to simulate their metabolic and regenerative abilities. In this study, sulfated bacterial cellulose (SBC) was prepared as the building block of cell scaffolds, motivated by the anionic nature and 3-dimensional structure of hepatic extracellular matrix, and its reaction condition for sulfate esterification was optimized by changing the reaction time. The analysis and study of the microscopic morphology, structure, and cytocompatibility of SBCs showed that they possess good biocompatibility and meet the requirements for tissue engineering. Next, SBC was mixed with gelatin for composite scaffolds (SBC/Gel) for culturing hepatocytes by homogenization and freeze-drying methods, whose physical properties such as pore size, porosity, and compression properties were compared with gelatin (Gel) scaffolds as the control group, and the cytological activity and hemocompatibility of the composite scaffolds were investigated. The results showed that the SBC/Gel composite has better porosity and compression properties, as well as good cytocompatibility and hemocompatibility, and could be applied to 3-dimensional culture of hepatocytes for drug screening or liver tissue engineering.
Targeting ASIC1a Promotes Neural Progenitor Cell Migration and Neurogenesis in Ischemic Stroke
Authors: Ge Hongfei , Zhou Tengyuan , Zhang Chao , Cun Yupeng , Chen Weixiang , Yang Yang , Zhang Qian , Li Huanhuan , Zhong Jun , Zhang Xuyang , Feng Hua , Hu Rong 
Published: March 2023

Cell replacement therapy using neural progenitor cells (NPCs) has been shown to be an effective treatment for ischemic stroke. However, the therapeutic effect is unsatisfactory due to the imbalanced homeostasis of the local microenvironment after ischemia. Microenvironmental acidosis is a common imbalanced homeostasis in the penumbra and could activate acid-sensing ion channels 1a (ASIC1a), a subunit of proton-gated cation channels following ischemic stroke. However, the role of ASIC1a in NPCs post-ischemia remains elusive. Here, our results indicated that ASIC1a was expressed in NPCs with channel functionality, which could be activated by extracellular acidification. Further evidence revealed that ASIC1a activation inhibited NPC migration and neurogenesis through RhoA signaling-mediated reorganization of filopodia formation, which could be primarily reversed by pharmacological or genetic disruption of ASIC1a. In vivo data showed that the knockout of the ASIC1a gene facilitated NPC migration and neurogenesis in the penumbra to improve behavioral recovery after stroke. Subsequently, ASIC1a gain of function partially abrogated this effect. Moreover, the administration of ASIC1a antagonists (amiloride or Psalmotoxin 1) promoted functional recovery by enhancing NPC migration and neurogenesis. Together, these results demonstrate targeting ASIC1a is a novel strategy potentiating NPC migration toward penumbra to repair lesions following ischemic stroke and even for other neurological diseases with the presence of niche acidosis.
Periodical evaluation of photovoltaic modules and diode parameter extraction method using multiple linear regression models
Authors: Farias-Basulto G. A. , Ulbrich C. , Schlatmann R. , Klenk R. 
Published: March 2023

Abstract
The stability and performance of photovoltaic (PV) modules can be assessed by outdoor testing where external conditions such as illumination and module temperature are measured at regular time intervals along with the jV-curve of the module. However, the fluctuation and seasonal variation of external conditions can make it difficult to trace changes such as degradation in PV-module properties (at e.g. standard test conditions). This contribution demonstrates the use of multiple linear regressions (MLR) to overcome these difficulties. The data gathered over large periods is condensed into a set of few predictors, that reproduce the jV parameters at infrequently encountered conditions that are required for comparison. Furthermore, the parameters of a physical device model are calculated directly from MLR-predictors, validating our procedure two-fold, by applying the MLR-method to simulated data, replicating the original input parameters, and comparing monthly parameter averages between the MLR-method and a known parameter extraction method.
COMPARISON OF TWO WAYS OF CONSTRUCTING A CROSS-SECTION KERNEL: DISCRETE AND CONTINUOUS
Authors: Викулов С.В. , Пахомова Л.В. , Инкижинов Н.С. 
Published: March 2023

В данной работе приводятся два способа построения ядра сечения для цилиндрических стержней, имеющих различные формы поперечного сечения. Дается название этих способов. Один из способов, общеизвестный в сопротивлении материалов, назван дискретным в соответствии с конечным числом угловых шагов нейтральных прямых, касающихся контура поперечного сечения. Ядро сечения, построенное дискретным способом, имеет форму выпуклого многоугольника с числом сторон, равным числу угловых шагов при окатывании касательной вокруг контура поперечного сечения на 360º. Второй способ построения ядра сечения назван непрерывным в соответствии с непрерывным поворотом касательной по криволинейному контуру поперечного сечения. Ядро сечения или его часть, соответствующая этому криволинейному контуру, имеет вид гладкой непрерывной линии. Эта гладкая кривая строится по выведенному уравнению ядра сечения. Формулы координат ядра сечения, соответствующие этим двум способам, сопоставляются между собой. Доказывается тождественность этих формул координат сечения. Приведена формула углового коэффициента касательной к контуру ядра сечения, которая является справедливой для обоих способов.
In this paper, two methods are given for constructing a cross-section core for cylindrical rods having different cross-sectional shapes. The name of these methods is given. One of the methods commonly known in the "Resistance of materials" is called discrete in accordance with a finite number of angular steps of neutral lines touching the contour of the cross section. The cross-section core, constructed in a discrete way, has the shape of a convex polygon with the number of sides equal to the number of angular steps when the tangent is rolled around the contour of the cross-section by 360 °. The second method of constructing the cross-section core is called continuous in accordance with the continuous rotation of the tangent along the curved contour of the cross-section. The core of the section or its part corresponding to this curved contour has the form of a smooth continuous line. This smooth curve is constructed according to the derived equation of the cross-section kernel. The formulas of the coordinates of the core of the section corresponding to these two methods are compared with each other. The identity of these formulas of the section coordinates is proved. The formula of the angular coefficient of the tangent to the contour of the core of the section is given. This formula is valid for both ways.
Pengaruh Metode Jigsaw Terhadap Hasil Belajar Siswa Kelas VII A Pada Materi Operasi Hitung Bentuk Aljabar SMP Negeri 8 Kota Bima
Authors: Sriaryaningsyih  
Published: March 2023

Tujuan dari penelitian ini adala untuk mengetahui hasil belajar siswa sebelum dilakukannya metode jigsaw kelas VII di SMP Negeri 8 kota bima dan mengetahui pengaruh metode jigsaw terhadap hasil belajar matematika siswa kelas VII di. SMP Negeri 8 kota bima.Penelitian ini menggunakan jenis penelitian kuasi eksperimen (quasi experimental). Berdasarkan analisis data dan pembahasan hasil penelitian yang telah diuraikan pada bab IV, maka peneliti dapat memberikan kesimpulan bahwa: ada pengaruh signifikan pada metode jigsaw terhadap hasil belajar siswa kelas VII terkait materi operasi hitung bentuk aljabar di SMPN 8 kota bima. Hal ini sesuai dengan pengujian hipotesis menggunakan uji t pada taraf 5% untuk hasil belajar dengan menggunakan metode jigsaw dengan nilai thitung = 4,478 > ttabel = 1,66426, dengan taraf signifikasi = 0,001 < 0,05 yang mempunyai arti Ho ditolak dan Ha diterima