bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Route lifetime in Vehicular Ad Hoc ?Networks Based on Skellam Distribution Model
Authors: Tawfeeq Mohammed Ali 
Published: January 2023

The emergence of smart cities and the need to use intelligent transportation systems has led to an increased reliance on vehicle ad hoc networks (VANET). The topology of VANET is highly dynamic, which results in a short effective routing time. This paper presents a two-stage algorithm to select a route that can sustain communication between vehicles for as long as possible while taking into account the variables that affect the VANET topology. The first stage uses Skellam distribution model to assess the connectivity probability of paths in ?a 2d road network based on traffic-flow and the number of vehicles ?joining and leaving the ?network, accordingly, the path with the highest connectivity is chosen. In the second stage, the control packets sent only to vehicles on the selected path to detect routes between source and destination, thus reducing the overhead of control packets and increasing network stability. ? the algorithm adopts the principle of global evaluation to ?estimate the lifetime ?of the ?detected ?routes within the chosen path. ?the route with the ?best estimated ?lifetime ?is ?chosen to be ?the active route. ?in the event of route failure, the validity of the next route in lifetime is confirmed to be adopted as the alternate route. The proposed algorithm was compared with both on-?demand distance ?vector routing protocol (AODV) protocol and the modified location-aided routing ??(LAR) ?protocol. The proposed algorithm showed greater network stability, higher performance in terms of longer lifetime route detection, less energy consumption and higher throughput.
A study of stress factors during the learning of anatomy in Gaston Berger University of Saint-Louis
Authors: Niang Mouhamadou Moustapha , Manyacka Ma Nyemb Philippe , Yattara Habsatou , Ndiaye Aïnina , Gaye Magaye , Ndiaye Abdoulaye 
Published: January 2023

Among medical students, stress has always been a major problem. Medical studies are known to be long, stressful, and difficult. The dropout rate is high in medical studies; it is often associated with chronic fatigue and a permanent state of stress. The objectives of our work were to determine the different aspects of stress, to assess the intensity of stress, to determine an association between perceived stress and socio-demographic characteristics; and to make recommendations to optimize our student’s performance.This was a cross-sectional and descriptive study aimed at determining the different aspects of stress experienced by license 2 and license 3 medical students at Gaston BERGER University during the teaching of anatomy. We proposed 29 questions with 5-level Likert scale responses.The response rate was 91.5% with a male predominance (sex ratio of 1.17). The minimum, average and maximum stress degrees were 4%, 54.52% and 100% respectively; the intensity was higher among female students (60%) than male students (50%); the youngest between 18 and 21 years old had a stress intensity of 50%; and 60% between 22 and 25 years old.Our study, which focused on the stress experienced by medical students during the “anatomy and organogenesis” teaching unit, highlighted many particularities. It appeared that stress is relatively common among medical students, and that most of them are moderately or highly stressed. We also found that the issue of stress is only rarely discussed with the teacher, or between students. Moreover, the existence of the “stress” factor and its poor management with students are directly correlated to academic performance.
Knowledge, attitude and practices towards plagiarism observed in undergraduate medical students at a teaching school in south east Asia
Authors: Agrawal Divya , Sagar Tamilisetti Vidya , Kachhawa Kamal , Kumar Sanjay 
Published: January 2023

In a student academic learning process, process of plagiarism starts very early from preparation for assessment, followed by seminar presentation. This plagiaristic research practice knowingly or unknowingly gets inculcated in student as habit. Studies published on ethics in research practice until now are from developed nations where ethics in research is taught in undergraduate training itself. Aim of study is to investigate knowledge, attitude and practices towards plagiarism in undergraduate medical students at a teaching school in south East Asia.We adopted cross sectional study design and study was done during February-April 2022 in a sample of 200 undergraduate medical students to assess knowledge, attitude and practices (KAP) towards plagiarism. All undergraduates (from 1 year to final year) of both genders were allowed to participate. Students not willing to be part of study were excluded. Validated questionnaire consisting of three sections addressing knowledge, attitude, and practice of plagiarism was utilized for assessment. Questionnaire consists of (a) Questions related to knowledge (b) Questions related to positive and negative attitudes towards plagiarism and (c) questions related to practice of plagiarism. Students were encouraged to fill all questions. These KAP Questionnaire forms were analysed after taking back from students and percentages were calculated. Data was analyzed by using Microsoft excel and Statistical Package for Social Sciences (SPSS) statistical software, version 16.Out of 200 participants, 52% were females and 48% were males. Mean±SD age of participants is 18.7±2.6 years. Majority of students (80%) know aboutethical principles in research and practices of plagiarism. Half of students (50%) had experience with research and instances of plagiarism and some know problems they should encounter if they do plagiarism. 70% appropriately answered domains which include plagiarism, 65% answered appropriately practices that may be considered as plagiarism and 50% answered appropriately practices that may not be regarded as plagiarism and only 40% appropriately answered republishing one’s own previous works whether to be considered plagiarism or notResponse to practices of plagiarism is around 20 to 40%. Questions like whether self-plagiarism should be considered serious or not has same response.This shows that majority of undergraduate medical students had knowledge regarding principles of ethics in research and problems they should encounter if they practice plagiarism. Majority have negative attitude towards plagiarism.
Meningkatkan Potensi Kewirausahaan dan Inovasi Produk di SMK N 1 Mojosongo
Authors: Gustiana Himmah Sekar Eka Ayu , Mahmudi Ayub , Jayani Syahrul Aji , Yudha Cornelius Satria , Shohih Esa Nur , Putro Firman Asto , Fuady Muhammad Iqbal Al , Paryanto Paryanto , Suci Windhu Griyasti 
Published: January 2023

<p><strong>ABSTRAK.</strong> Kewirausahaan merupakan salah satu tuntutan kompetensi lulusan siswa di SMK Negeri 1 Mojosongo. Kompetensi tersebut menjadi salah satu indikator kualitas sumber daya manusia lulusan SMK. Tim Manajemen sekolah selalu berusaha meningkatkan kualitas sumber daya siswa dan tenaga pengajarnya. Salah satu terobosan yang dilakukan adalah bekerjasama dengan Prodi D3 Teknik Kimia Universitas Sebelas Maret untuk meningkatkan wawasan siswanya. Konsep kerjasama ini berupa transfer keilmuan yang dikemas dalam kegiatan pengabdian masyarakat. Kegiatan ini memiliki beberapa tahapan dimulai dari identifikasi masalah mitra yaitu perlunya pemahaman konsep kewirausahaan, business plan, pemodalan dana hibah, konsep desain dan inovasi produk dan pemasaran usaha. Pada tahap awal kegiatan siswa diminta mengikuti pretest untuk mengetahui tingkat mula pemahaman. Tahap kedua paparan materi kewirausahaan dan diskusi, tahap ketiga demo sekaligus praktik langsung pembuatan inovasi produk pangan dari buah nipah. Kegiatan diakhiri dengan post test dan testimoni hasil kegiatan. Dari kegiatan yang telah dilakukan, menunjukkan hasil bahwa terdapat peningkatan pemahaman peserta tentang kewirausahaan dan inovasi produk menggunakan teknologi sederhana. </p><p> </p><p><strong>ABSTRACT. </strong>Entrepreneurship is one of the required competencies for students' graduation at SMK Negeri 1 Mojosongo. Thus, this competency is one of the indicators to determine the quality of graduates from SMK N 1 Mojosongo. The School management has been trying to improve the quality of students and teaching staff. Collaboration between SMK N 1 Mojosongo and Diploma 3 of the Chemical Engineering Study Program of Universitas Sebelas Maret is one of the breakthroughs to increase students' insight. The concept of this collaboration is in the form of knowledge transfer which is packaged in community service activities. This activity begins with identifying the problems experienced by partners such as the need to understand the concept of entrepreneurship, business plans, grant funding, design concepts, product innovation, and business marketing. Before the main agenda begins, students are asked to take a pretest to determine their initial level of understanding. After a presentation on entrepreneurship, the students practice making food product innovations from Nypa fruticans. Finally, the students took the post-test and gave testimonials on the results of the activities. The results of this activity indicate that there is an increase in participants' understanding of entrepreneurship and product innovation with simple technology.</p>
Status Penyakit Busuk Pucuk dan Penyakit Gugur Buah pada Tanaman Kelapa di Sulawesi Utara
Authors: Nln Rahma , Saka Oscar , Santosa Budi , Hosang Meldy L.A 
Published: January 2023

Penyakit busuk pucuk dan penyakit gugur buah pada tanaman kelapa disebabkan oleh <em>Phytophthora palmivora. </em>Serangan <em>P. palmivora</em> pada bagian pucuk dapat mematikan tanaman kelapa dalam waktu yang singkat. Serangan pada bagian buah, menyebabkan buah gugur, sehingga sangat berpengaruh terhadap penurunan produksi kelapa. Penelitian ini bertujuan untuk mengetahui kerusakan dan dampak serangan penyakit busuk pucuk dan penyakit gugur buah terhadap produksi tanaman kelapa di Sulawesi Utara. Peneltian dilaksanakan sejak bulan Maret sampai Mei 2022 pada tanaman kelapa Genjah Kuning Nias di perkebunan kelapa milik PTPN XIV di Desa Tiniawangko, Kecamatan Tenga, Kabupaten Minahasa Selatan, Provinsi Sulawesi Utara dan di Laboratorium Terpadu Hama dan Penyakit, Balai Penelitian Tanaman Palma di Mapanget, Sulawesi Utara. Hasil penelitian menunjukkan bahwa penyakit busuk pucuk dan penyakit gugur buah dapat menyebabkan kerusakan yang serius pada pertanaman kelapa Genjah Kuning Nias karena kedua penyakit ini secara bersamaan dapat menyerang tanaman kelapa. Persentase tanaman kelapa terinfeksi penyakit busuk pucuk sebesar 31,53% sehingga tanaman tersebut terancam mati. Selain itu juga dapat terjadi penurunan produksi sebesar 25,00 % akibat serangan penyakit gugur buah.
Localized phosphorus promotes nutrient productivity of Brassica chinensis genotype with strong root morphological plasticity
Authors: Gao Wei , Zhang Deshan , Tang Xiaoyan , Ruan Yunze 
Published: January 2023

Abstract
Crops adjust root morphological and/or exudation traits in response to phosphorus (P) availability and localized P, governing crop productivity. However, how the intraspecific plasticity of root P-acquisition strategies influences plant adaptation to localized P fertilization across doses remains obscure. Root P-acquisition traits were assessed in Brassica chinensis L. Xiaqing and Yanchun grown in soil with four mineral P fertilization levels (0, 15, 24, and 30 kg P ha-1) and with broadcasted and localized P across two levels (15 and 24 kg P ha-1) to characterize efficient strategies in relation to large plant P productivity. The Xiaqing genotype stimulated the growth of roots with large specific lengths and increased the exudation of acid phosphatase and carboxylates under 15 kg P ha-1 fertilization compared to those in 24 and 30 kg P ha-1 soil. Conversely, Yanchun only increased root elongation in 15 kg P ha-1 soil compared with crops in soil fertilized with 30 kg P ha-1. Xiaqing and Yanchun stimulated local root growth in P-rich soil with 15 and 24 kg P ha-1, but with longer roots in the former than the latter genotype. Localized P at the 15 kg P ha-1 level, compared with 24 kg P ha-1, increased root length density in the patchy soil zone and promoted P acquisition in Xiaqing and Yanchun. In conclusion, the Xiaqing genotype exhibited strong root plasticity in response to low and localized P application compared with the Yanchun genotype. Nutrient-efficient genotype coupling with localized fertilization is important to increase crop yield and save fertilizer in vegetable cropping systems.
Ozone Decreases CRMP2 Phosphorylation by Inhibiting Sema3A to Ameliorate Chronic REM Sleep Deprivation-Induced Cognitive Deficits in Mice
Authors: jingru tu , Williams John P. , Sun LiNa , Yan YiNing , Liu Yu , An JianXiong 
Published: January 2023

Abstract
Sleep is essential for proper cognitive functioning. Ozone can delay both the aging process as well as the associated neurodegeneration. An untested hypothesis is that ozone may play a role in reducing the cognitive impairment associated with sleep deprivation. This study was designed to elucidate the mechanism of ozone’s effect on chronic REM sleep deprivation induced cognitive dysfunction in mice. Ozone ameliorated cognitive dysfunction in chronic REM sleep deprived mice, increased the number of dendritic spines in the hippocampus region and decreased neuronal loss. Administration of ozone may protect against chronic REM sleep deprivation induced cognitive dysfunction by enhancing the expression ofSema3A and PlexinA1 concentrations as well as P-CRMP2/CRMP2 in the hippocampus. Moreover, ozone was associated with acetylation of α-tubulin, which, in turn, is associated with microtubule network dynamics and modulates ATP synthase activity. In conclusion, ozone may play a neuroprotective role and improve chronic REM sleep deprivation induced spatial recognition and learning memory dysfunction in mice.
Using Semi-Automatically Annotation System on Medical Entity Recognition
Authors: TUNG CHIAMING , HUANG JINGRUNG , CAI JIACHUN , LU WENHSIANG 
Published: January 2023

Abstract
It is more and more common that people ask questions on the web and seek suggestion before visiting medical institutions. These corpus resources may be valuable for further research on natural languages processing for Medicine. Amazon provided a service called “Amazon Comprehend Medical” that could help medical experts to extract six kinds of the important terms from the articles. In this research, we proposed a medical entity recognition model to identify ten medical entity terms. A semi-auto annotation system was also developed to extract medical entity terms from the questions. The expected result shows that the annotation system could reduce 40% labeling time and provides a tagging interface to add medical entity terms manually.
Did the COVID-19 pandemic impact the dietary intake of individuals living with and beyond breast, prostate, and colorectal cancer and who was most likely to experience change?
Authors: Taylor Katie S , Beeken Rebecca J , Fisher Abigail , Lally Phillippa 
Published: January 2023

Abstract
Purpose
The present work investigated dietary changes among individuals living with and beyond cancer (LWBC) from before to during the pandemic. To identify those at greatest risk of unhealthy changes, it was further examined whether patterns varied with sociodemographic, health-related, and COVID-19-related characteristics.
Methods
This longitudinal cohort study analysed data from 716 individuals LWBC participating in the Advancing Survivorship Cancer Outcomes Trial (ASCOT). Using data provided before and during the pandemic, changes in fruit and vegetable, snack, and alcohol intake were tested using mixed-effect regression models.
Results
Fruit and vegetable (95%CI:-0.30;-0.04), and alcohol consumption (95%CI:-1.25;-0.31) decreased, whilst snacking increased (95%CI:0.19;0.53). Women and individuals with limited social contact were more likely to reduce fruit and vegetable intake during the pandemic. Women and individuals with poorer sleep quality, limited social contact, shielding requirements, and without higher education were more likely to increase snacking during the pandemic. Individuals with poorer sleep quality, greater anxiety and depression levels, and regular social contact were more likely to decrease alcohol consumption during the pandemic.
Conclusions
Findings suggest unhealthy dietary changes for fruit, vegetable, and snack intake but healthy changes for alcohol consumption in response to the pandemic. These changes appear to differ across various characteristics, suggesting the pandemic has not equally impacted everyone. Findings highlight the need for targeted post-COVID strategies to support individuals LWBC most adversely affected by the pandemic, including women and socially isolated individuals. This encourages resources to be prioritised amongst these at-risk groups to prevent further negative impact of the pandemic.
Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study
Authors: Lilja-Lund Otto , Maripuu Martin , Kockum Karin , Andersson Johanna , Lindam Anna , Nyberg Lars , Laurell Katarina 
Published: January 2023

Abstract
Background: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce.
Aim: To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material.
Method: A sample of 104 participants (median [IQR] 75 [72–80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p <0.05 were used.
Results: Median (IQR) time to follow-up was 25 (23–26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045).
Conclusion: Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH.
Advanced Stage, High-Grade Primary Tumor Ovarian Cancer: A Multi-Omics Dissection and Biomarker Prediction Process
Authors: Honar Yousof Saeedi , Javaher Saleh , Soleimani Marziye , Zarebkohan Amir , Farhadihosseinabadi Behrouz , Tohidfar Masoud , Abdollahpour-Alitappeh Meghdad 
Published: January 2023

Abstract
Ovarian cancer (OC) incidence and mortality rates are estimated to increase globally in the years to come. Early diagnosis of OC is still one of the most significant challenges facing researchers due to extensive metastases and the lack of recognition of biomarkers in advanced stages of high-grade primary tumors (HGPTs). In this study, OC cell lines were analyzed using bioinformatics study and gene expression screening, utilizing Gene Expression Omnibus (GEO) the microarray dataset with 53 HGPTs and 10 normal samples were analyzed by using GEO2r to figure out differently-expressed genes (DEGs). Subsequently, Gene set enrichment analysis (GSEA), ChIP enrichment analysis (ChEA), eXpression2Kinases (X2K), and Human Protein Atlas (HPA) were used to analyze signaling pathways, transcription factors (TFs), kinases, and proteome analysis, respectively. Protein-protein interaction (PPI) networks were made by using STRING and Cytoscape Software. Co-expression and hub genes were determined via STRING database and cytoHubba plug-in, and DEGs were confirmed by using gene expression profiling interactive analysis (GEPIA). KIAA0101, RAD51AP1, FAM83D, CEP55, PRC1, CKS2, CDCA5, NUSAP1, ECT2 and TRIP13 were found to be the top 10 hub genes. At the same time, SIN3A, VDR, TCF7L2, NFYA, and FOXM1 were identified as the top 5 TFs in HGPT. Ultimately, the clustering of hub genes was carried out using the available tools in the protein atlas server, based on which 5 out of 10 candidate genes, including CEP55, PRC1, CKS2, CDCA5 and NUSAP1, were chosen as markers. miRNAs analysis showed that hsa-miR-215-5p, hsa-miR-193b-3p, hsa-miR-192-5p and could target the largest number of HGPT genes. Collectively, HGPT-related genes, especially hub genes, TFs, miRNAs and pathways seem to have a great potential as novel biomarkers for HGPT as well as diagnosis and treatment strategies in OC.
Beyond Lights: The Changing Impact of Rural Electrification on Indian Agriculture
Authors: Ray Sudatta , Pullabhotla Hemant 
Published: January 2023

Abstract
Rural electrification (RE) policies in the developing world primarily focus on household power, often at the cost of electricity supply to other productive sectors of the economy. We examine the consequences of this imbalance in RE policy priority on agricultural development in India. Electric pumping of groundwater for irrigation is a major driver of India's agricultural growth. However, the government of India shifted its RE focus towards universal household electrification starting early 2000s. Using a newly constructed panel-dataset spanning three decades, we find that districts electrifying after the policy shift (“late-electrifiers”) experience much lower gains in electrified groundwater irrigation. On average, electrifying 100 additional rural households is associated with an increase of two additional electrified wells among late-electrifiers -- eight times lower compared to 16 electrified wells per 100 electrified households among early-electrifying districts. Our estimates imply that late-electrifiers would have witnessed nearly 20% more irrigated cropland in the dry season if RE policy priorities had not shifted away from agriculture. These results highlight the need to complement household electrification with powering income-generating sectors of the rural economy.
Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism
Authors: Nakashima Yu , Kawakami Atsushi , Ogasawara Yasushi , Maeki Masatoshi , Tokeshi Manabu , Dairi Tohru , Morita Hiroyuki 
Published: January 2023

AbstractThe lasso peptide MS-271 is a ribosomally synthesized and post-translationally modified peptide (RiPP) consisting of 21 amino acids with D-tryptophan at theC-terminus, and is derived from the precursor peptide MslA. MslH, encoded in the MS-271 biosynthetic gene cluster (msl), catalyzes the epimerization at the Cα center of the MslAC-terminal Trp, leading toepi-MslA. The detailed catalytic process, including the catalytic site and cofactors, has remained enigmatic. Herein, based on X-ray crystallographic studies in association with the MslA core peptide, we show that MslH is a mechanistically unprecedented epimerase with a unique calcineurin-like fold. The crystal structure analysis followed by site-directed mutagenesis, docking simulation, and ICP-MS studies demonstrated that MslH employs acid/base chemistry to facilitate the reversible epimerization of theC-terminal Trp21 of MslA, by utilizing two pairs of His/Asp catalytic residues that are electrostatically tethered to a six-coordination motif with a Ca(II) ion via water molecules.