bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Continuity Of Care Model Based On Family Empowerment Improves The Family's Ability In Managing Hypertension Among Elderly
Authors: Riasmini Ni Made , Achjar Komang Ayu Henny , Hartini Tien , Khatimah Husnul , C.Gomez Erljohn , Riyanto Riyanto 
Published: September 2023

Family empowerment in the early detection and monitoring of risk factors for hypertension among the elderly is very important because a family is the main support system and the best place and source of happiness for the elderly. Through continuous care (Continuity of Care/CoC), it is hoped that families will be able to assist the elderly in managing hypertension problems, to improve their health status and quality of life among the elderly. This study aims to determine the effect of the CoC model based on family empowerment in increasing family ability (knowledge, attitudes, and behavior) to manage hypertension among the elderly. The research was conducted in Denpasar City with a total sample of 62 people. The research design is a quasi-experiment with a control group design. Data analysis used t-test, Chi-Square, and Multiple Logistic Regression. The results showed that there were significant differences in the ability of families to manage hypertension in the elderly before and after applying the model to the intervention group, namely knowledge (p value=0.019), attitude (p value=0.002), and behavior (p value=0.003). Likewise, significant differences were found in the family's ability to manage hypertension in the elderly after the application of the model between the intervention and control groups, namely knowledge and attitudes (p-value = 0.001) and behavior (p-value = 0.002). The results of the multivariate test found that length of stay had an effect on family attitudes and work on family behavior in managing hypertension in the elderly, apart from the influence of the CoC model. Recommendation: the CoC model intervention based on family empowerment can be used as a form of intervention in empowering family potential so that it can assist the elderly in a community setting.
Writing a Good Research Paper
Authors: Aminat Akintobi  , Muhammad Ridwan  
Published: September 2023

A research paper is a piece of academic writing that provides analysis, interpretation, and arguments based on in-depth independent research. A good research paper solidifies a researcher’s skill in scholarly writing. This paper describes the process it takes to write a good research paper; it highlights the processes necessary to write various sections of a research paper - Abstracts, Introduction, Literature Review, Methodology, Results and Discussion, and Conclusion. Digesting this research paper's content would ensure researchers can document information that would otherwise seep through due to a lack of research writing skills. The aim of this is to ensure that researchers can make original contributions to the scholarly base. An author's career, institution, and nation will be impacted by high-quality publication in indexed journals. Significant rejections could result from poor scientific writing. Therefore, writing a successful scientific publication for a peer-reviewed journal takes considerable time and expertise. A few easy actions and advice are provided to help researchers publish the findings of their work in the right scientific publications with greater expertise. Effective scientific writing frequently adheres to a specific format with important elements. The introduction to a specific issue with relevant background literature and theories to be studied, a list and explanation of the techniques, results, and a discussion that connects the results to the topic's broader information should all be included in a scientific paper's main text. For early researchers aiming to raise the caliber of their submissions for publication, this review piece is essential.
The Impact of Christian Teachings on National Development
Authors: Akinwumi O.S.  
Published: September 2023

National development is about improving a nation to improve the living standards of the people within that nation. This can be achieved when the people are provided with basic livelihood requirements such as employment. It is indeed a process that creates growth, brings in progress and positive changes. Christian teachings refer to the specific teachings of the Bible on various subjects which include: uniqueness of Jesus, one God (trinity), necessity of the cross (salvation), resurrection and second coming of Jesus and inspiration of the scriptures. From time immemorial , christian teachings had made tremendous impact on national development. The objective of this work, therefore, is to elucidate the impact of christian teachings on national development. In view of its historical nature, the work employs historical method in its analysis. The findings of this work, however, reveal that the moral and ethical atrophy being witnessed in the nation can be curbed through christian teachings and adherence to them will enhance rapid national development.
Partnering essential oils with antibiotics: proven therapies against bovine Staphylococcus aureus mastitis
Authors: Abd El-Hamid Marwa I. , El-Tarabili Reham M. , Bahnass Mosa M. , Alshahrani Mohammed Abdulrahman , Saif Ahmed , Alwutayd Khairiah Mubarak , Safhi Fatmah Ahmed , Mansour Abdallah Tageldein , Alblwi Noaf Abdullah N. , Ghoneim Mohammed M. , Elmaaty Ayman Abo , Al-harthi Helal F. , Bendary Mahmoud M. 
Published: September 2023

IntroductionThere is an urgent need to develop therapeutic options for biofilm-producing Staphylococcus aureus (S. aureus). Therefore, the renewed interest in essential oils (EOs), especially carvacrol, linalool and eugenol, has attracted the attention of our research group.MethodsMultidrug resistance and multivirulence profiles in addition to biofilm production of S. aureus strains isolated from cows with mastitis were evaluated using both phenotypic and genotypic methods. The antimicrobial and antibiofilm activities of EOs were tested using both in vitro and molecular docking studies. Moreover, the interactions between commonly used antibiotics and the tested EOs were detected using the checkerboard method.ResultsWe found that all our isolates (n= 37) were biofilm methicillin resistant S. aureus (MRSA) producers and 40.5% were vancomycin resistant S. aureus (VRSA). Unfortunately, 73 and 43.2% of the recovered MRSA isolates showed multidrug resistant (MDR) and multivirulence patterns, respectively. The antimicrobial activities of the tested EOs matched with the phenotypic evaluation of the antibiofilm activities and molecular docking studies. Linalool showed the highest antimicrobial and antibiofilm activities, followed by carvacrol and eugenol EOs. Fortunately, synergistic interactions between the investigated EOs and methicillin or vancomycin were detected with fractional inhibitory concentration index (FICI) values ≤ 0.5. Moreover, the antimicrobial resistance patterns of 13 isolates changed to sensitive phenotypes after treatment with any of the investigated EOs. Treatment failure of bovine mastitis with resistant S. aureus can be avoided by combining the investigated EOs with available antimicrobial drugs.ConclusionWe hope that our findings can be translated into a formulation of new pharmaceutical dosage forms against biofilm-producing S. aureus pathogens.
Pericardial effusion following percutaneous left atrial appendage closure using the LAmbre device
Authors: Yu Yibo , Chu Huimin , Wang Binhao , He Bin , Fu Guohua 
Published: September 2023

BackgroundPericardial effusion (PE) is an uncommon but serious complication that occurs following percutaneous left atrial appendage closure (LAAC). There are few data regarding PE following implantation of the LAmbre device for LAAC.MethodsPatients with nonvalvular atrial fibrillation (AF) undergoing percutaneous LAAC using the LAmbre device at the Arrhythmia Center of Ningbo First Hospital from October 2017 to March 2021 were retrospectively reviewed (n = 133). PE was defined as acute if diagnosed ≤7 days post LAAC (n = 3, 2.3%) or delayed if diagnosed &gt;7 days post LAAC (n = 3, 2.3%). The clinical characteristics and procedural data were compared between patients with PE (PE group, n = 6) and without PE (non-PE group, n = 127). The predictors of PE were analyzed by logistic regression.ResultsAll patients with PE recovered following treatment by pericardiocentesis. Patients with PE were found to have a higher incidence of congestive heart failure (50.0% vs. 13.4%, P = 0.044) and had larger measured LAA orifice diameters (33.5 mm ± 6.0 mm vs. 28.3 mm ± 5.2 mm, P = 0.018) and landing zone diameters (27.8 mm ± 4.8 mm vs. 23.9 mm ± 4.8 mm, P = 0.054) compared with those without PE. The diameters of the device umbrellas (31.7 mm ± 5.6 mm vs. 26.9 mm ± 5.0 mm, P = 0.026) and covers (36.3 mm ± 4.6 mm vs. 33.4 mm ± 4.0 mm, P = 0.075) implanted were larger in the PE group compared to the non-PE group. Univariate logistic regression revealed that congestive heart failure (OR = 6.47, 95% CI = 1.21–34.71, P = 0.029) and LAA maximal orifice diameter (OR = 1.22, 95% CI = 1.02–1.45, P = 0.027) were both associated with PE following LAmbre device implantation.ConclusionsIn this single-center experience, both acute and delayed PE were uncommon in patients with AF following LAmbre device implantation. Congestive heart failure and a larger LAA orifice were identified as predictors for the occurrence of PE.
Analysing the elevation-distributed hydro-climatic regime of the snow covered and glacierised Hunza Basin in the upper Indus
Authors: Nazeer Aftab , Maskey Shreedhar , Skaugen Thomas , McClain Michael E. 
Published: September 2023

In the high altitude Hindukush Karakoram Himalaya (HKH) mountains, the complex weather system, inaccessible terrain and sparse measurements make the elevation-distributed precipitation and temperature among the most significant unknowns. The elevation-distributed snow and glacier dynamics in the HKH region are also little known, leading to serious concerns about the current and future water availability and management. The Hunza Basin in the HKH region is a scarcely monitored, and snow- and glacier-dominated part of the Upper Indus Basin (UIB). The current study investigates the elevation-distributed hydrological regime in the Hunza Basin. The Distance Distribution Dynamics (DDD) model, with a degree day and an energy balance approach for simulating glacial melt, is forced with precipitation derived from two global datasets (ERA5-Land and JRA-55). The mean annual precipitation for 1997–2010 is estimated as 947 and 1,322 mm by ERA5-Land and JRA-55, respectively. The elevation-distributed precipitation estimates showed that the basin receives more precipitation at lower elevations. The daily river flow is well simulated, with KGE ranging between 0.84 and 0.88 and NSE between 0.80 and 0.82. The flow regime in the basin is dominated by glacier melt (45%–48%), followed by snowmelt (30%–34%) and rainfall (21%–23%). The simulated snow cover area (SCA) is in good agreement with the MODIS satellite-derived SCA. The elevation-distributed glacier melt simulation suggested that the glacial melt is highest at the lower elevations, with a maximum in the elevation 3,218–3,755 masl (14%–21% of total melt). The findings improve the understanding of the local hydrology by providing helpful information about the elevation-distributed meltwater contributions, water balance and hydro-climatic regimes. The simulation showed that the DDD model reproduces the hydrological processes satisfactorily for such a data-scarce basin.
Seasonal dynamics of sediment organic carbon storage for the upper streams of the Yangtze River
Authors: Hou Jianfeng , Li Fei , Wang Zhihui , Li Xuqing , Cao Rui , Yang Wanqin 
Published: September 2023

IntroductionForest streams reserve more than 90% of the organic carbon (OC) in sediments, thus playing crucial roles in the global carbon cycle. Although forest streams are widely distributed across various forest regions, seasonal dynamics of OC in forest sediments have not been fully investigated.MethodsHere, we sampled soils (0–5  cm) in 15 representative forest stream sediments for 5 critical periods (snowmelt season, early growing season, growing season, late growing season, and seasonal snow cover season) during a one-year investigation in a geologically fragile subalpine coniferous forest catchment in the upper reaches of the Yangtze River in Sichuan province and the OC concentrations were measured by potassium dichromate external heating method.ResultsThe OC concentration of stream sediments ranged from 6.39 to 458.93  g kg−1, and the average was 84.56  g kg−1 for 15 streams in 5 critical periods during a 1-year investigation. Correspondingly, their stocks ranged from 2.05 to 310.56  kg m−2, and the average was 46.03  kg m−2. The maximum and minimum OC stocks were consistently observed during the late growing season and the snowmelt season, respectively. Otherwise, the OC stocks ranged from 1.31 to 218.05, 1.29 to 182.64, and 0.99 to 190.38  kg m−2 for the upstream, midstream, and downstream sediments, and the average was 39.36, 36.58, and 37.93  kg m−2, respectively. The average ratios of the OC stocks of the upstream and downstream ranged from 0.10–6.31, with an average of 1.43, during 5 critical periods, which indicated that the forest stream sediments may play crucial roles as carbon sources.DiscussionFurthermore, based on regression analysis, we found that the seasonal dynamics of OC concentrations and stocks were mainly regulated by precipitation, temperature, sediment depth, and litter carbon input to the streams together. These findings demonstrate that forest stream sediments may play crucial roles in the carbon biogeochemical cycle of subalpine forests and adjoining streams.
The functional response of human monocyte-derived macrophages to serum amyloid A and Mycobacterium tuberculosis infection
Authors: Kawka Malwina , Płocińska Renata , Płociński Przemysław , Pawełczyk Jakub , Słomka Marcin , Gatkowska Justyna , Dzitko Katarzyna , Dziadek Bożena , Dziadek Jarosław 
Published: September 2023

IntroductionIn the course of tuberculosis (TB), the level of major acute phase protein, namely serum amyloid A (hSAA-1), increases up to a hundredfold in the pleural fluids of infected individuals. Tubercle bacilli infecting the human host can be opsonized by hSAA-1, which affects bacterial entry into human macrophages and their intracellular multiplication.MethodsWe applied global RNA sequencing to evaluate the functional response of human monocyte-derived macrophages (MDMs), isolated from healthy blood donors, under elevated hSAA-1 conditions and during infection with nonopsonized and hSAA-1-opsonized Mycobacterium tuberculosis (Mtb). In the same infection model, we also examined the functional response of mycobacteria to the intracellular environment of macrophages in the presence and absence of hSAA-1. The RNASeq analysis was validated using qPCR. The functional response of MDMs to hSAA-1 and/or tubercle bacilli was also evaluated for selected cytokines at the protein level by applying the Milliplex system.FindingsTranscriptomes of MDMs cultured in the presence of hSAA-1 or infected with Mtb showed a high degree of similarity for both upregulated and downregulated genes involved mainly in processes related to cell division and immune response, respectively. Among the most induced genes, across both hSAA-1 and Mtb infection conditions, CXCL8, CCL15, CCL5, IL-1β, and receptors for IL-7 and IL-2 were identified. We also observed the same pattern of upregulated pro-inflammatory cytokines (TNFα, IL-6, IL-12, IL-18, IL-23, and IL-1) and downregulated anti-inflammatory cytokines (IL-10, TGFβ, and antimicrobial peptide cathelicidin) in the hSAA-1 treated-MDMs or the phagocytes infected with tubercle bacilli. At this early stage of infection, Mtb genes affected by the inside microenvironment of MDMs are strictly involved in iron scavenging, adaptation to hypoxia, low pH, and increasing levels of CO2. The genes for the synthesis and transport of virulence lipids, but not cholesterol/fatty acid degradation, were also upregulated.ConclusionElevated serum hSAA-1 levels in tuberculosis enhance the response of host phagocytes to infection, including macrophages that have not yet been in contact with mycobacteria. SAA induces antigen processing and presentation processes by professional phagocytes reversing the inhibition caused by Mtb infection.
The IL-25/ILC2 axis promotes lung cancer with a concomitant accumulation of immune-suppressive cells in tumors in humans and mice
Authors: Bahhar Ilham , Eş Zeynep , Köse Oğuzhan , Turna Akif , Günlüoğlu Mehmet Zeki , Çakır Aslı , Duralı Deniz , Magnusson Fay C. 
Published: September 2023

BackgroundGroup 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 cells help protect the host against helminth infection while exacerbating allergic-like inflammation and tissue damage in the lung. In the context of cancer, IL-33-activated ILC2 cells were found to bear anti-tumoral functions in lung cancer while IL-25-activated ILC2 cells promoted tumorigenesis in colorectal cancer. The role of IL-25-activated ILC2 cells in lung cancer remains to be addressed.MethodsWe examined the overall survival of human non-small cell lung cancer (NSCLC) patients according to IL25 expression as well as the distribution of ILC2 cells and regulatory T cells (Tregs) in various NSCLC patient tissues and peripheral blood (PB) of healthy donors (HDs). We analyzed the effect of adoptive transfer of IL-25-activated ILC2 cells on tumor growth, metastasis and survival in a heterotopic murine model of lung cancer.ResultsWe report that human NSCLC patients with high IL-25 expression have reduced overall survival. Moreover, NSCLC patients bear increased frequencies of ILC2s compared to HDs. Frequencies of Tregs were also increased in NSCLC patients, concomitantly with ILC2s. In mice bearing heterotopic lung cancer, adoptive transfer of IL-25-activated ILC2s led to increased tumor growth, increased metastasis and reduced survival. The frequencies of monocytic myeloid-derived suppressor cells (M-MDSCs) were found to be increased in the tumors of mice that received ILC2s as compared to controls.ConclusionOverall, our results indicate that the IL-25/ILC2 axis promotes lung cancer potentially by recruiting immune-suppressive cells to the tumors both in humans and in mice, and that it may therefore represent a suitable novel target for NSCLC immunotherapeutic development.
Analysis of the structural response and strengthening performance of prefabricated substation walls under flood loads
Authors: Yao Han , Zhang Liang , Wang Qing , Han Huina , Han Fengkai , Tian Li 
Published: September 2023

Introduction: The study focuses on evaluating the reliability of prefabricated perimeter walls in substations during flood events. It employs a sophisticated numerical model based on actual engineering data to assess their load-bearing capabilities. The research investigates the impact of crucial flood parameters on the structural behavior of these walls, examines the force transmission mechanisms, and suggests “W-shaped” reinforcement techniques to mitigate stress-related issues.Methods: To meet our research goals, we developed an extensive numerical model for prefabricated perimeter walls, incorporating real-world engineering data. This model enabled us to analyze critical flood parameters, such as flood depth, flow velocity, and flood erosion. Furthermore, we investigated the force transmission mechanisms within the walls and introduced “W-shaped” reinforcement strategies to improve their load-bearing capacity.Results: Our results indicate that flood depth and flow velocity have a substantial impact on the performance of prefabricated perimeter walls, while flood erosion has a minor effect. Safety concerns become prominent when flood depth exceeds 1.0 m or flow velocity surpasses 3 m per second. Analysis of force transmission mechanisms reveals greater displacements at higher water levels. Critical areas, including wall panel-column and wall panel-foundation connections, experience heightened stress levels.Discussion: Our study highlights the significant role of flood depth and flow velocity in evaluating the load-bearing capacity of prefabricated perimeter walls in substation environments. To address potential structural weaknesses, we recommend implementing “W-shaped” wall reinforcement methods, which efficiently decrease both displacement and stress. These findings carry implications for substation design and flood resilience, underscoring the importance of comprehensive flood risk management strategies to protect internal facilities during floods.
N2-fixing bacteria are more sensitive to microtopography than nitrogen addition in degraded grassland
Authors: Li Chengyi , Valencia Enrique , Shi Yan , Zhou Guiyao , Li Xilai 
Published: September 2023

IntroductionSoil bacteria play a crucial role in the terrestrial nitrogen (N) cycle by fixing atmospheric N2, and this process is influenced by both biotic and abiotic factors. The diversity of N2-fixing bacteria (NFB) directly reflects the efficiency of soil N fixation, and the diversity of NFB in degraded alpine meadow soil may change with different N fertilizing levels and varied slopes. However, how N addition affects the diversity of NFB in degraded alpine meadows, and whether this influence varies with slope, remain poorly understood.MethodsWe conducted an N addition field experiment at three levels (2, 5, and 10 g N·m−2·a−1) to study the effects of N addition on soil NFB diversity on two different slopes in a degraded meadow on the Tibetan Plateau.ResultsThere were significant differences in the dominant bacterial species between the two slopes. The Chao1 index, species richness, and beta diversity of NFB did not differ significantly between slopes, but the Shannon index did. Interestingly, N addition had no effect on the diversity of NFB or the abundance of dominant bacteria. However, we did observe a significant change in some low-abundance NFB. The community composition and diversity of NFB were significantly positively correlated with slope and soil physicochemical properties (e.g., total potassium, pH, and total nitrogen).ConclusionsOur study highlights the variation in NFB communities among different slopes in degraded alpine meadows and their resilience to exogenous N addition. Our results also underscore the importance of considering the effects of micro-topography on soil microbial communities in future studies of alpine ecosystems.