bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model‐Based Cyber Security at the Enterprise and Systems Level
Authors: Brooks Mitchell , Hause Matthew 
Published: August 2023

AbstractModel‐Based Engineering (MBE) has transformed the worlds of mechanical, electrical, chemical, software, systems engineering, and now cybersecurity. Model based cybersecurity allows this concern to be addressed as an integrated part of the solution as opposed to being a separate solution. To best take advantage of this, we must examine which modeling practices, languages, and standards are best suited to handle cybersecurity. Currently, UAF is the most effective tool being used to provide Model‐Based Cyber Security at the Enterprise and Systems Level. It achieves this largely through its integrated security viewpoint as well as by facilitating capability‐based engineering. Furthermore, it allows modelers to integrate with other cybersecurity‐focused modeling tools to include cybersecurity in the digital thread. The INCOSE Future of Systems Engineering (FuSE) Initiative defined 12 key concepts including “Capability‐Based Security Engineering” and “Security as a Functional Requirement.” This paper discusses these FuSE concepts and demonstrates how they can be effectively realized via the use of UAF and shows how UAF coupled with complementary tools and standards provides powerful verification and validation capabilities. Note that this paper is derived from INCOSE Insight articles Brooks, Hause (2022) and Hause, Brooks (2022) published in a special issue on FuSE Security. References are included below.
Toward Systems Engineering Meta‐Methodology
Authors: Mordecai Yaniv 
Published: August 2023

AbstractA significant portion of Systems Engineering research deals with building methodologies, methods, frameworks, techniques, and tools for performing various systems engineering activities, which are arguably better than legacy ones. However, there is no clear guidance for systems engineering methodology building. In fact, there is barely any guidance about how to build methodology for anything. Systems researchers must practice what they preach – a systems approach – even in the very process of designing systems engineering systems and methods. This paper is a step toward forming a consolidated body of knowledge on systems methodology building – conception, design, construction, evaluation, and deployment – indeed much like the way we build systems. While some aspects of this methodology may seem intuitive, we introduce several insights that may be useful for informing researchers about the fundamentals of methodological research, as well as about the appropriate justification of such research.
Systems Engineering Approach for the SPHEREx Telescope Mission
Authors: Alibay Farah , Bottom Heather , Hutchinson Leina , Rocca Jennifer 
Published: August 2023

AbstractThe Spectro‐Photometer for the History of the Universe, Epoch of Reionization and Ices Explorer (SPHEREx) was selected in 2019 as a NASA Astrophysics Medium Class Explorer mission to perform the first infrared all‐sky spectral survey. The mission consists of a single wide field of view telescope mounted on top of a Ball Configurable Platform (BCP) spacecraft bus. Over the course of its two‐year mission, the SPHEREx observatory will perform four all‐sky surveys and provide spectroscopic measurements of hundreds of millions of galaxies and a diversity of astronomical phenomena. SPHEREx is currently in phase C, post‐Critical Design Review (CDR) and is in the process of building and testing hardware in preparation for observatory Assembly, Test, and Integration (AI&T) in early 2024. The observatory is expected to launch on a Falcon 9 rocket no earlier than February 2025.Project level systems engineering support is provided by the Jet Propulsion Laboratory (JPL) and oversees the technical development of the observatory and its ground operations. Systems engineers are staffed throughout all the systems and act as a key interface between the mission's many partners. This paper focuses on the systems engineering approach for the SPHEREx mission including its architecture, verification and validation methodology, and its risk and resource management approach.
Linking UAF and SysML Models: Achieving Alignment between Enterprise and System Architectures
Authors: Martin James N , Brookshier Daniel 
Published: August 2023

AbstractThe Unified Architecture Framework (UAF) is designed to facilitate the modeling of a system (at a high level) along with the driving enterprise objectives and strategies, operational activities and mission threads, capability objectives and roadmaps, and a variety of other considerations that apply to the system under development. However, when the system (or a collection of systems) is modeled using UAFML, there is a challenge in linking the UAF model to the corresponding system models created using SysML to ensure proper alignment is established and maintained between the Enterprise and System levels. This paper examines four alternative ways of achieving this alignment and discusses the benefits and drawbacks of each approach.
Effect of dual‐optical pulses with temporal energy distribution on laser ablation performance in in vivo zebrafish model
Authors: Shin Hwarang , Lee Yeachan , Hwang Junghyun , Lim Seonghee , Choi Jongman , Gong Seung Pyo , Kang Hyun Wook 
Published: August 2023

AbstractA Q‐switched laser system has been used in a single‐pulse mode for skin melasma treatments because of instant heat deposition in the target. Despite the efficient ablation of the melanophores in the skin, the single, high‐fluence pulse often causes undesirable damage to the surrounding tissue, leading to high recurrence rates. This study aims to investigate the feasibility of dual‐optical pulses with a temporal energy distribution on the melasma treatment in in vivo zebrafish models in comparison to that of the single optical pulse. Based on the optical detection, the dual‐optical pulses had a temporal energy distribution ratio of 4:1 and an interval of 61 μs between the two consecutive pulses. According to the histological analysis, the dual pulses removed melanophores and induced a few apoptotic nuclei with minimal recurrence. This study demonstrated that the feasibility of dual‐optical pulses (energy ratio = 4:1) could enhance the laser ablation performance in vivo.
Pumpkin seed oil: a comprehensive review of extraction methods, nutritional constituents, and health benefits
Authors: Hu Zicong , Hu Chaofan , Li Yanpo , Jiang Qiaojun , Li Qunhe , Fang Cuilan 
Published: August 2023

AbstractPumpkin seed oil (PSO), a rich source of nutrients, is extracted from the seeds of different pumpkin varieties for food and medicines. This article aims to provide an evidence‐based review of the literature and to explore the extraction technologies, nutritional properties, and biological activity of PSO. From previous literature, PSO contains a large proportion of unsaturated fatty acids, with linoleic acid as the main component, and an amount of tocopherol, phytosterol, and phenolic acids. Some differences in the yield, composition, and physicochemical properties of PSO can be associated with the pumpkin's cultivars and the extraction methods. Some novel technologies involved in supercritical fluid extraction, enzyme‐assisted aqueous extraction, and ultrasound‐assisted extraction have been replacing the conventional technologies gradually as promising methods for the safe, non‐polluting, and effective recovery of PSO. This healthy vegetable oil was reported by several in vitro and in vivo studies to have potential protective roles in oxidative stress, inflammation, cancer, and cardiovascular diseases. © 2023 Society of Chemical Industry.
Development and validation of high‐performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets
Authors: Mahmoudi Abdelghani , De Francia Silvia , Paul Prasanta 
Published: August 2023

Clarithromycin is a very important macrolide antibiotic used to treat bacterial infections in human and veterinary medicine. This study reports the development and validation of cost‐effective, simple, precise, accurate, and robust high‐performance liquid chromatography (HPLC) for the determination of clarithromycin (CLA) in tablets. Reversed‐phase chromatography was conducted using a standard column at 55°C with ultraviolet detection at 215 nm. A mobile phase consisting of acetonitrile –2‐methyl‐2‐propanol –potassium phosphate buffer was used at a flow rate of 1.0 mL/min. The proposed method displayed good linearity, precision, accuracy, robustness, and specificity. The present HPLC was compared with capillary electrophoresis and bioassay methods and the results indicated that there was no significant difference between these methods. Moreover, the obtained results demonstrated the validity of the isocratic HPLC, which allows reliable quantitation of CLA in pharmaceutical samples. Thus, it can be used as a substitute alternative methodology for the routine quality control of this medicine, in situations where other methods are less accessible in the laboratory.
Sync for Genes Phase 5: Computable artifacts for sharing dynamically annotated FHIR‐formatted genomic variants
Authors: Dolin Robert , Heale Bret S. E. , Gupta Rohan , Alvarez Carla , Aronson Justin , Boxwala Aziz , Gothi Shaileshbhai R. , Husami Ammar , Shalaby James , Babb Lawrence , Wagner Alex , Chamala Srikar 
Published: August 2023

AbstractIntroductionVariant annotation is a critical component in next‐generation sequencing, enabling a sequencing lab to comb through a sea of variants in order to hone in on those likely to be most significant, and providing clinicians with necessary context for decision‐making. But with the rapid evolution of genomics knowledge, reported annotations can quickly become out‐of‐date. Under the ONC Sync for Genes program, our team sought to standardize the sharing of dynamically annotated variants (e.g., variants annotated on demand, based on current knowledge). The computable biomedical knowledge artifacts that were developed enable a clinical decision support (CDS) application to surface up‐to‐date annotations to clinicians.MethodsThe work reported in this article relies on the Health Level 7 Fast Healthcare Interoperability Resources (FHIR) Genomics and Global Alliance for Genomics and Health (GA4GH) Variant Annotation (VA) standards. We developed a CDS pipeline that dynamically annotates patient's variants through an intersection with current knowledge and serves up the FHIR‐encoded variants and annotations (diagnostic and therapeutic implications, molecular consequences, population allele frequencies) via FHIR Genomics Operations. ClinVar, CIViC, and PharmGKB were used as knowledge sources, encoded as per the GA4GH VA specification.ResultsPrimary public artifacts from this project include a GitHub repository with all source code, a Swagger interface that allows anyone to visualize and interact with the code using only a web browser, and a backend database where all (synthetic and anonymized) patient data and knowledge are housed.ConclusionsWe found that variant annotation varies in complexity based on the variant type, and that various bioinformatics strategies can greatly improve automated annotation fidelity. More importantly, we demonstrated the feasibility of an ecosystem where genomic knowledge bases have standardized knowledge (e.g., based on the GA4GH VA spec), and CDS applications can dynamically leverage that knowledge to provide real‐time decision support, based on current knowledge, to clinicians at the point of care.
Therapeutic Benefit of Sensory Trick in Cervical Dystonia
Authors: Mahajan Abhimanyu , Gonzalez David A. , Stebbins Glenn T. , Comella Cynthia 
Published: August 2023

AbstractBackgroundSensory tricks (STs) are voluntary maneuvers that dampen the abnormal movement in cervical dystonia (CD).ObjectivesTo investigate the effect of ST on CD severity and treatment.MethodsData on 1039 individuals with a modified Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score were extracted from the CD Patient Registry for Observation of OnabotulinumtoxinA (onabotA) Efficacy study. Univariate and multivariate models evaluated the direct and indirect impact of ST on CD severity and treatment, while controlling for confounds.ResultsComplete ST was associated with a 10% lower mean onabotA dose. Absence of complete ST was associated with a higher onabotA dose after controlling for dystonia severity (OR = 1.37, P = 0.04). ST moderated the relationship between dystonia severity and toxin dose (β = −0.16, P = 0.02).ConclusionsST is related to lower CD severity and toxin dose. It may have a direct effect on lowering toxin dose, independent of CD severity.
Familial gigantiform cementoma with recurrent ANO5 p.Cys356Tyr mutations: Clinicopathological and genetic study with literature review
Authors: Zhou Zheng , Zhang Ye , Zhu Lijing , Cui Yajuan , Gao Yan , Zhou Chuan‐Xiang 
Published: August 2023

AbstractBackgroundFamilial gigantiform cementoma (FGC) is a rare tumor characterized by the early onset of multi‐quadrant fibro‐osseous lesions in the jaws, causing severe maxillofacial deformities. Its clinicopathological features overlap with those of other benign fibro‐osseous lesions. FGC eventually exhibits progressively rapid growth, but no suspected causative gene has been identified.MethodsIn this study, three patients with FGC were recruited, and genomic DNA from the tumor tissue and peripheral blood was extracted for whole‐exome sequencing.ResultsResults showed that all three patients harbored the heterozygous mutation c.1067G > A (p.Cys356Tyr) in the ANO5 gene. Furthermore, autosomal dominant mutations in ANO5 at this locus have been identified in patients with gnathodiaphyseal dysplasia (GDD) and are considered a potential causative agent, suggesting a genetic association between FGC and GDD. In addition, multifocal fibrous bone lesions with similar clinical presentations were detected, including five cases of florid cemento‐osseous dysplasia, five cases of polyostotic fibrous dysplasia, and eight cases of juvenile ossifying fibromas; however, none of them harbored mutations in the ANO5 gene.ConclusionOur findings indicate that FGC may be an atypical variant of GDD, providing evidence for the feasibility of ANO5 gene testing as an auxiliary diagnostic method for complex cases with multiple quadrants.
A low‐profile dual‐wideband magnetoelectric dipole antenna with stable gain
Authors: Ye Da Gui , Jiang Huan , Ye Liang Hua , Zhang Yong Ping , Tian Xinxin , Li Jian‐Feng , Wu Duo‐Long 
Published: August 2023

AbstractA dual‐wideband magnetoelectric dipole antenna is proposed. The magnetoelectric dipole is fed by a hook‐shaped metal sheet. To increase the gain at the upper band, the radiation arm of the electric dipole is designed in stepped shape. To widen the impedance bandwidth of the lower band, stepped‐shaped metal walls are employed and placed along the edges of the ground plane. To further improve and stabilize the higher band gain, four parasitic umbrella‐shaped metals are utilized. By using this novel scheme, a magnetoelectric dipole antenna with dual‐wideband operation is designed. It introduces two wide bandwidths of 35.3% (0.698–1 GHz) for the lower band and 63% (1.52–2.9 GHz) for the upper band. The lower‐band gain is stabilized within 7.3 ± 0.6 dBi, while the upper‐band gain is stabilized within 9.2 ± 0.8 dBi. The antenna dimension is only 0.41λL × 0.41λL × 0.1λL (λL denotes the wavelength at 0.698 GHz in vacuum).
Efficient optical fiber communication in the metro access domain based on an optical multicarrier source
Authors: Ullah Rahat , Ullah Sibghat , Khan Jahangir , Al‐Atawi Abdullah A. , Alwageed Hathal S. 
Published: August 2023

AbstractThis paper proposes an efficient optical fiber communication scheme for an optical metro access network (OMAN) based on an optical multicarrier (OMC) generator. The central office (CO)'s foundation is a novel, cost‐effective OMC‐generating technique. The OMC is designed from a pulsed laser source and three cascaded electro‐optic modulators (EOMs) driven by an amplified RF source of 20 GHz signal that has generated more than 60 frequencies with excellent tone‐to‐noise ratio (TNR) ~ 40 dB and amplitude excursions from zero to 3 dB. The conventional CO is replaced with a cost‐effective OMC‐based source with an effective switching mechanism, which is necessary and equally important to be handled reliably. The downstream data of 20 Gbps per carrier is transmitted using a duo‐binary coding scheme. Six remote nodes (RNs) supported by the suggested OMC source, at each RN 10 optical network units (ONUs), can be deployed having distance laps of 5 km between the RNs, the distance between the RNs and the ONUs is kept at 2 km, the ONUs were tested w.r.t the bit error rate (BER) and the power penalties for the proposed transmissions. The BER for different fiber lengths from 5 to 25 km at various RNs and ONUs ranges were calculated and demonstrated from 1e−3 to 1e−13, showing the feasibility of the proposed OMAN.
A shared aperture antenna with reconfigurable pattern by common and differential modes
Authors: Chen Menglong , Hu Haoquan , Lei Shiwen , Sun Kai , Tian Jing , Chen Bo 
Published: August 2023

AbstractIn this letter, a compact pattern‐reconfigurable (PR) antenna for indoor communication is proposed, which can provide one conical, one broadside, and two tilted patterns. The proposed antenna comprises a shared radiation patch with two highly isolated ports and a reconfigurable feeding network. By activating each port independently, a dipole mode with broadside pattern and a monopole mode with conical pattern are acquired, respectively. Meanwhile, inspired by the theory of common and differential modes, two tilted patterns toward and are realized by combining dipole and monopole modes. As a result, four‐type reconfigurable patterns can be obtained. To realize reconfigurability, a functional reconfigurable feeding network is designed with innovation. The proposed antenna is fabricated and measured. The measured overlapped −10 dB impedance bandwidth is 3.28–3.71 GHz (12.3%), and the peak radiation efficiency is superior to 82.7%. The experimental results indicate that the proposed PR antenna has a wide bandwidth and stable radiation patterns, which exhibits attractive potential for fifth‐generation indoor communication in sub‐6 GHz.
Kritische Rohstoffe: Weder selten noch alternativlos
Authors: Ehrensberger Christian 
Published: August 2023

AbstractViel Lärm um Seltene Erden für grüne und digitale Technologien, etwa für Elektroautos und Windräder – aber am Ende braucht man sie dafür gar nicht. Denn schon deuten sich Alternativen an.
Trendbericht Biochemie 2023 (3/3): Ein Neutron extra: deuterierte Moleküle in der chemischen Biologie
Authors: Broichhagen Johannes , Roßmann Kilian 
Published: August 2023

AbstractFortschritte bei der Analyse epigenetischer Basen helfen unter anderem dabei, Krankheiten früher zu diagnostizieren. In Inneren von Encapsulinen, das sind proteinbasierte Nanocapside, laufen (bio)chemische Reaktionen geschützt ab, sie können daher für die Katalyse genutzt werden. Deuterierung von Fluoreszenzfarbstoffen erhöht deren Extinktion, Fluoreszenzlebensdauer und Helligkeit, sodass sich die deuterierten Farbstoffe besser für hochauflösende Mikroskopiemethoden eignen.
Associations of residential greenness and ambient air pollution with overweight and obesity in older adults
Authors: Ye Lihong , Zhou Jinhui , Tian Yanlin , Cui Jia , Chen Chen , Wang Jun , Wang Yueqing , Wei Yuan , Ye Jiaming , Li Chenfeng , Chai Xin , Sun Chris , Li Fangyu , Wang Jiaonan , Guo Yanbo , Jaakkola Jouni J. K. , Lv Yuebin , Zhang Juan , Shi Xiaoming 
Published: August 2023

AbstractObjectiveThis study aimed to examine the impact of greenness and fine particulate matter <2.5 μm (PM2.5) on overweight/obesity among older adults in China.MethodsA total of 21,355 participants aged ≥65 years were included from the Chinese Longitudinal Healthy Longevity Survey between 2000 and 2018. Normalized difference vegetation index (NDVI) with a radius of 250 m and PM2.5 in a 1 × 1‐km grid resolution were calculated around each participant's residence. Cox proportional hazards models were used to estimate the effects of NDVI and PM2.5 on overweight/obesity. Interaction and mediation analyses were conducted to explore combined effects.ResultsThe study observed 1895 incident cases of overweight/obesity over 109,566 person‐years. For every 0.1‐unit increase in NDVI the hazard ratio of overweight/obesity was 0.91 (95% CI: 0.88–0.95), and for every 10‐μg/m3 increase in PM2.5 the hazard ratio was 1.11 (95% CI: 1.07–1.14). The effect of NDVI on overweight/obesity was partially mediated by PM2.5, with a relative mediation proportion of 20.10% (95% CI: 1.63%‐38.57%).ConclusionsGreenness exposure appears to lower the risk of overweight/obesity in older adults in China, whereas PM2.5, acting as a mediator, partly mediated this protective effect.
Inventory of real‐world data sources in Japan: Annual survey conducted by the Japanese Society for Pharmacoepidemiology Task Force
Authors: Kumamaru Hiraku , Togo Kanae , Kimura Tomomi , Koide Daisuke , Iihara Naomi , Tokumasu Hironobu , Imai Shinobu 
Published: August 2023

AbstractPurposeThe Database Task Force of the Japan Society for Pharmacoepidemiology began its annual surveys of databases available for clinico and pharmacoepidemiological studies in 2010. In this report, we summarize the characteristics of the databases available in Japan based on the results of our 2021 survey to illustrate the recent developments in the infrastructure for database research in Japan.MethodsWe included 20 major databases from the academia, government, or industry that were accessible to third parties. We used a web‐based questionnaire to ask the database providers about their characteristics, such as their organization, data source(s), numbers of individuals enrolled, age distribution, code(s) used, and average follow‐up periods.ResultsWe received responses from all 20 databases approached: eight hospital‐based databases, six insurer‐based databases, four pharmacy‐based databases, and two in the “other” category. Among them, 17 contained information from medical claims, pharmacy claims, and/or Diagnosis Procedure Combination data. Most insurer databases contained health check‐up data that could be attached to the claims component. Some hospital‐based databases had data from electronic medical records. Most insurer‐based databases collected data from the insurers of working‐age employees and therefore had limited coverage of older people. Most databases coded their medication data using the Japanese reimbursement codes, and many provided Anatomical Therapeutic Chemical Classification codes.ConclusionsThe number of databases available for clinico and pharmacoepidemiological research and the proportion of the population they cover are increasing in Japan. The differences in their characteristics mean that the appropriate database must be selected for a particular study purpose.