bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline depressive symptoms as predictors of efficacy and tolerability of the treatment with duloxetine: a network analysis approach
Authors: Maciaszek Julian , Pawłowski Tomasz , Hadryś Tomasz , Misiak Błażej 
Published: June 2023

IntroductionDepression is considered one of the most prevalent and burdensome mental disorders. Only 50–60% of patients respond to first-line treatment. Individuals with depression might benefit from personalized treatment, tailored to the individual needs of the patient. In this study, we aimed to explore the baseline characteristics of depressive symptoms associated with a good response to duloxetine treatment using a network analysis. Additionally, the relationship between baseline psychopathological symptoms and treatment tolerability was assessed.MethodsThe sample of 88 drug–free patients with active depressive episode, who started monotherapy with increasing doses of duloxetine were evaluated. The Hamilton Depression Rating Scale (HAM-D) was used to assess depression severity and the UKU side effect rating scale to monitor adverse drug reactions (ADRs). A network analysis that explored interactions of specific baseline depression symptoms, treatment efficacy and tolerability was performed.ResultsThe node representing duloxetine treatment efficacy was directly connected to the nodes representing the first HAM-D item (“depressed mood”) (edge weight = 0.191) and duloxetine dose (edge weight = 0.144). The node representing ADRs was directly connected to only one node representing the baseline score of the HAM-D anxiety (psychic) item (edge weight = 0.263).DiscussionOur findings indicate that individuals with depression presenting greater levels of depressed mood and lower levels of anxiety symptoms might better respond to the treatment with duloxetine in terms of efficacy and tolerability.
Epidemiology of companion animal AMR in the United States of America: filling a gap in the one health approach
Authors: Sobkowich Kurtis E. , Weese J. Scott , Poljak Zvonimir , Plum Andy , Szlosek Donald , Bernardo Theresa M. 
Published: June 2023

IntroductionAntimicrobial resistance (AMR) is a global health concern that affects all aspects of the One Health Triad, including human, animal, and environmental health. Companion animals, such as cats and dogs, may contribute to the spread of AMR through their close contact with humans and the frequent prescription of antimicrobials. However, research on AMR in companion animals is limited, and there are few surveillance measures in place to monitor the spread of resistant pathogens in the United States.MethodsThis study aims to explore the practicality of using data from commercial laboratory antimicrobial susceptibility testing (AST) services for epidemiological analyses of AMR in companion animals in the United States.ResultsThe study analyzed 25,147,300 individual AST results from cats and dogs submitted to a large commercial diagnostic laboratory in the United States between 2019 and 2021, and found that resistance to certain antimicrobials was common in both E. coli and S. pseudintermedius strains.ConclusionThere has been a paucity of information regarding AMR in companion animals in comparison to human, environmental and other animal species. Commercial AST datasets may prove beneficial in providing more representation to companion animals within the One Health framework for AMR.
Synchronous and metachronous multiple primary cancers in melanoma survivors: a gender perspective
Authors: Guzzinati Stefano , Buja Alessandra , Grotto Giulia , Zorzi Manuel , Manfredi Mariagiovanna , Bovo Eleonora , Del Fiore Paolo , Tropea Saveria , Dall’Olmo Luigi , Rossi Carlo R. , Mocellin Simone , Rugge Massimo 
Published: June 2023

BackgroundLong-term survivors of cutaneous malignant melanoma (CMM) risk subsequent malignancies due to both host-related and environmental risk factors. This retrospective population-based study differentially assesses the risk of synchronous and metachronous cancers in a cohort of CMM survivors stratified by sex.MethodsThe cohort study (1999–2018) included 9,726 CMM survivors (M = 4,873, F = 4,853) recorded by the cancer registry of all 5,000,000 residents in the Italian Veneto Region. By excluding subsequent CMM and non-CMM skin cancers, the incidence of synchronous and metachronous malignancies was calculated according to sex and tumor site, standardizing for age and calendar year. The Standardized Incidence Ratio (SIR) was calculated as the ratio between the number of subsequent cancers among CMM survivors and the expected number of malignancies among the regional population.ResultsIrrespective of the site, the SIR for synchronous cancers increased in both sexes (SIR = 1.90 in males and 1.73 in females). Both sexes also demonstrated an excess risk for synchronous kidney/urinary tract malignancies (SIR = 6.99 in males and 12.11 in females), and women had an increased risk of synchronous breast cancer (SIR = 1.69). CMM male survivors featured a higher risk of metachronous thyroid (SIR = 3.51, 95% CI [1.87, 6.01]), and prostate (SIR = 1.35, 95% CI [1.12, 1.61]) malignancies. Among females, metachronous cancers featured higher SIR values than expected: kidney/urinary tract (SIR = 2.27, 95% CI [1.29, 3.68]), non-Hodgkin’s lymphoma (SIR = 2.06, 95% CI [1.24, 3.21]), and breast (SIR = 1.46, 95% CI [1.22, 1.74]). Females had an overall increased risk of metachronous cancers in the first 5 years after CMM diagnosis (SIR = 1.54 at 6–11 months and 1.37 at 1–5 years).ConclusionAmong CMM survivors, the risk of metachronous non-skin cancers is higher than in the general population and differs significantly by sex. These results encourage sex-tailored interventions for metachronous secondary cancer prevention.
The resilience of short food supply chains during the COVID-19 pandemic: a case study of a direct purchasing network
Authors: Ušča Maija , Tisenkopfs Talis 
Published: June 2023

IntroductionThe COVID-19 pandemic has presented challenges to global food supply chains. Since the beginning of the pandemic researchers have studied various food supply chain issues influenced by the COVID-19 crisis, including impacts on consumer behavior, and logistical and organizational changes to food supply chains. Despite the proliferation of studies on food supply chains during the pandemic, only a few researchers have focused on short food supply chains and their resilience. Therefore, the aim of this study was to explore the resilience of short food supply chains during the COVID-19 pandemic using a direct purchasing (DP) network as a case study. The study considered three research questions. (1) How has the functioning of the DP network changed during the COVID-19 pandemic? (2) What role do resilience elements (i.e., readiness to shocks, responsiveness to disruption, and recovery from the crisis) play in the short food supply chain response to the COVID-19 crisis? (3) Which innovations in the short food supply chain would further the recovery process, and thus resilience, after the crisis?MethodsThis article presents a case study of a direct organic food purchasing network in Latvia. The analysis of economic data regarding the dynamics of organic product demand and supply in the DP network was supplemented with an analysis of qualitative data gathered through semi-structured in-depth interviews with representatives of three groups of DP network participants: consumers, producers, and DP network organizers.Results and discussionFrom the consumer and producer experiences, the DP network was a flexible short food chain that could adapt quickly in a crisis. While the number of DP distribution points and total number of purchases decreased during the pandemic, a statistically significant increase in the number of product units sold compared to the pre-COVID-19 period was observed. From the perspective of food chain resilience elements, the reactive strategies of the DP network as a short food supply chain were highlighted. During the COVID-19 pandemic, the organizational and product innovations introduced in the DP network played a key role in enhancing the resilience of the short supply chain in the context of the wider food system.
Evaluation of Aztreonam and Ceftazidime/Avibactam Synergism against Klebsiella pneumoniae by MALDI-TOF MS
Authors: Wilhelm Camila Mörschbächer , Inamine Everton , Martins Andreza Francisco , Barth Afonso Luís 
Published: June 2023

Introduction: Resistance to carbapenems due to the co-production of NDM and ESBL or NDM and KPC is increasing. Therefore, combined therapy with aztreonam (ATM) plus ceftazidime/avibactam (CZA) has been recommended. Then, it is necessary to develop and evaluate fast and simple methods to determine synergism in vitro in microbiology laboratories. Objective: To develop a method to determine the synergism of ATM and CZA by MALDI-TOF MS (SynMALDI). Method: Klebsiella pneumoniae (n = 22) isolates with blaNDM and/or blaKPC genes were tested. The time–kill curve assay was performed for four isolates (three positives for blaNDM and blaKPC and one positive for blaNDM only). For SynMALDI, each isolate was incubated for 3 h in 4 tubes containing brain–heart infusion broth with the following: (1) no antibiotic; (2) ATM at 64 mg/L; (3) CZA at 10/4 mg/L; and (4) ATM at 64 mg/L plus CZA at 10/4 mg/L. After incubation, the bacterial protein extract was analyzed by MALDI-TOF MS, and the relative growth (RG) was determined for each isolate, considering intensities of the peaks of the bacterium incubated with antibiotic (tubes 2, 3, and 4) to the same bacterium incubated without antibiotic (tube 1), as follows: RG = IntensityWith antibiotic/IntensityWithout antibiotic. The combination was determined as synergistic when there was an RG decrease of 0.3 in the antibiotic combination in relation to the RG of the most active antibiotic alone. Results: The combination of ATM plus CZA proved to be synergic by time–kill curve assay. All isolates tested with the SynMALDI method also presented synergism. Conclusions: Detection of synergism for ATM plus CZA combination can be determined by MALDI-TOF MS, providing fast results in order to improve patient treatment.
A Comprehensive Review of the Hermite–Hadamard Inequality Pertaining to Quantum Calculus
Authors: Tariq Muhammad , Ntouyas Sotiris K. , Shaikh Asif Ali 
Published: June 2023

A review of results on Hermite–Hadamard (H-H) type inequalities in quantum calculus, associated with a variety of classes of convexities, is presented. In the various classes of convexities this includes classical convex functions, quasi-convex functions, p-convex functions, (p,s)-convex functions, modified (p,s)-convex functions, (p,h)-convex functions, tgs-convex functions, η-quasi-convex functions, ϕ-convex functions, (α,m)-convex functions, ϕ-quasi-convex functions, and coordinated convex functions. Quantum H-H type inequalities via preinvex functions and Green functions are also presented. Finally, H-H type inequalities for (p,q)-calculus, h-calculus, and (q−h)-calculus are also included.
The Effect of Radiotherapy-Related Anxiety and Depression on Quality of Life in Cancer Patients
Authors: ARIKAN Fatma , ÖZTÜRK Nazli , YERLİ Nuran , AKSU Melek Gamze 
Published: June 2023

Objective: This study aimed to investigate anxiety and depression levels and quality of life in cancer patients before and after radiotherapy.
Materials and Methods: This study is a prospective descriptive study. Data were collected via patient information form, Hospital Anxiety Depression Scale (HADS) and European Organization for Research and Treatment (EORTC QLQ-C30) before and after radiotherapy. Data were analyzed by chi-squared test, t-test, and multivariate regression analysis.
Results: There was a statistically significant difference between the mean scores for the subdimensions of the QOL scale before and after radiotherapy. Anxiety and depression before radiotherapy were found to affect the emotional function subdimension by 52% and anxiety after radiotherapy by 67%.
Conclusion: The findings of this study emphasise the significant effect of age, chemotherapy, presence of metastasis, anxiety and depression on quality of life in cancer patients receiving radiotherapy. We recommend that oncology nurses should evaluate anxiety and depression and provide training in cancer patients receiving radiotherapy
A very rare disease of lymphatic malformation 6: five new patients and review of the literatur
Authors: GERİK CELEBİ Hamıde Betul , AKBAS Murat , YÜCE Tuncay , CEYLANER Serdar , ÇAM Sırrı 
Published: June 2023

Objective: Lymphatic Malformation 6 (MIM no:616843) is characterized by generalized edema, bilateral pleural effusions, ascites and non-immune hydrops fetalis. PIEZO1 gene has been associated with the LMPHM6 disorder. Here, we aimed to evaluate five patients from two different families, with various clinical presentations of generalized lymphatic dysplasia.
Materials and Methods: Between January 2015 and January 2021, 5 cases with were evaluated with a pre-diagnosis of congenital lymphatic malformation. Whole exome sequencing was performed on the probands, and family segregation analysis was performed by Sanger sequencing.
Results: We identified a novel compound heterozygous PIEZO1 gene: NM_001142864.4: c.4030_4032delGAG (E1344del)/ c.5455_5456delAA (K1819Efs*46) variants in the first family and a novel homozygous PIEZO1 gene: c.5876A>G (D1959G) variant in the second family.
Conclusion: This study, which presents the clinical features and variations of five patients with long-term follow-up, contributed to the phenotypic and mutation spectrum of Lymphatic Malformation 6. The novel compound heterozygous E1344del/K1819Efs*46 variation leads to a premature stop codon that caused a shorter protein product. It was thought that two compound nonsense variations might be associated with the poor prognosis of family 1. Also, the second novel c.5876A>G (D1959G) biallelic homozygous mutation was thought to be associated with impaired PIEZO1 by causing loss of function. This study was the first LMPHM6 report from the Turkish population.
Keywords: Neurofibromatosis type 1, Next generation DNA sequencing, NF1 gene, novel variants
Ідентифікація сейсмічних подій природнього та військового характеру з використанням цифрових лазерних сейсмометрів
Authors: Петров Вячеслав Васильович , Бріцький Олександр Ігорович , Крючин Андрій Андрійович , Щербина Сергій Валентинович 
Published: June 2023

Наводяться результати досліджень сейсмічних подій природнього та військового характеру з використанням цифрових лазерних сейсмометрів. Дослідження спрямовані на ідентифікацію сейсмічних подій шляхом використання прецизійних лазерних сейсмометрів і методів кореляційного аналізу. Актуальність таких досліджень підтверджується підвищенням сейсмічної активності зі значними руйнівними наслідками (Туреччина, Сирія) та агресивними діями Російської Федерації щодо України. Події останніх років свідчать про необхідність моніторингу переміщення важкої техніки та її використання поблизу державного кордону України. Сутність проблеми посилюється широкомасштабним маскуванням таких подій з погляду повітряного, космічного та радіолокаційного спостереження і створенням завад засобам зв’язку. Подібне маскування важко виконати у сейсмічному фізичному полі, але для моніторингу переміщення важкої військової техніки потрібно використовувати надчутливі сейсмометри. Такі сейсмометри розроблені в Інституті проблем реєстрації інформації НАН України. Їхньою особливістю є застосування цифрових лазерних інтерферометрів як вимірювальних елементів переміщень земної поверхні з точністю до 2 нм. Ідентифікація виконується шляхом обчислення взаємно кореляційних функцій попередньо записаних сейсмічних портретів важливих подій і поточних сейсмічних записів. При експериментальних дослідженнях використовувалися сейсмічні портрети вантажних і пасажирських залізничних потягів. При цьому виявлялися потяги за портретами п’ятирічної давнини. Очевидно, що з використанням запропонованого підходу можна ідентифікувати рух важкої військової техніки. Це можуть бути танки, самохідні артилерійські установки, бойові машини піхоти. Окремо досліджувалася сейсмічна реакція на дії ствольної артилерії.
L’échographie : le nouveau couteau suisse pour l’évaluation de l’âge osseux, de la puberté, et de la thyroïde chez l’enfant et l’adolescent
Authors: Deladoey Johnny , Spörri Diego , Vuissoz Jean-Marc 
Published: June 2023

L’échographie « au lit du patient » (point-of-care ultrasonography, POCUS, terme pris au sens large dans cet article) devient un outil de plus en plus pertinent lors de l’évaluation des enfants et adolescents en clinique d’endocrinologie pédiatrique. En effet, au cours de la dernière décennie, le coût des appareils échographiques a diminué, leur taille s’est réduite alors que la qualité des images s’est améliorée. Ceci permet aux pédiatres d’utiliser l’échographie lors de l’évaluation de la croissance (âge osseux), de la puberté (échographie testiculaire ou pelvienne) et de la thyroïde, notamment. Son usage permet un triage rapide entre cas bénins et cas pathologiques qui nécessiteront des investigations supplémentaires.
ПОНЯТТЯ «МУЗЕЙНИЙ ПРЕДМЕТ» НА ПЕРЕТИНІ З ДОКУМЕНТОЗНАВСТВОМ ТА МУЗЕЄЗНАВСТВОМ
Authors: Шатрова Марина 
Published: June 2023

Здійснено теоретичне обґрунтування поняття «образотворчий документ» як частини поняття «музейний предмет». Досліджено, що поняття оригінальний «образотворчий документ» є складовою часиною поняття «музейний предмет». Здійснено дослідження оригінальних образотворчих документів, класифіковано і виокремлено проблеми їх функціонування та реєстрації. Проаналізовано низку публікацій в яких частково розглядаються теоретичні аспекти дослідження окремих образотворчих документів працівниками Національної бібліотеки України імені В. І. Вернадського НАН України.
Odd Harmonious Labeling of the Zinnia Flower Graphs
Authors: Firmansah Fery , Tasari Tasari , Yuwono Muhammad Ridlo 
Published: June 2023

An odd harmonious graph is a graph that satisfies the odd harmonious labeling properties. In this study, a new graph class construction is presented, namely zinnia flower graphs and variations of the zinnia flower graphs. The research method used is qualitative and includes several phases, namely data collection, data processing and analysis, and verification of the results. The purpose of this research is to find a new class of graphs that is a family of odd harmonious graphs. We will prove that prove that the zinnia flower graph and its variations satisfy odd harmonious labeling properties. The result of this research is that the zinnia flower graph and its variations are odd harmonious graphs.
Keywords: Flower graph; odd harmonious graph; odd harmonious labelling; zinnia flower graph
Pelabelan Harmonis Ganjil dari Graf Bunga Zinnia
ABSTRAK
Graf yang memiliki sifat pelabelan harmonis ganjil adalah graf harmonis ganjil. Pada penelitian ini akan didapatkan konstruksi graf bunga zinnia dan variasi graf bunga zinnia. Metode penelitian yang digunakan adalah penelitian kualitatif yang terdiri beberapa tahapan yaitu pengumpulan data, pengolahan dan analisis data, serta verifikasi hasil. Tujuan penelitian ini adalah menemukan kelas graf baru yang merupakan keluarga dari graf harmonis ganjil. Hasil penelitian ini diperoleh bahwa graf bunga zinnia dan variasi graf bunga zinnia merupakan graf harmonis ganjil.
Kata kunci: Graf bunga; graf bunga zinnia; graf harmonis ganjil; pelabelan harmonis ganjil
Отечественные разработки белковых систем типа «Коллаген» для решения задач отраслевого импортозамещения
Authors: Соколов Александр Юрьевич 
Published: June 2023

Введение. В контексте решения проблемы белка, представлены технологические решения для рационального использования белковых ресурсов животного происхождения в пищевой промышленности, общественном питании, отрасли первичной обработки сырья животного происхождения, крайне актуальные для АПК РФ в условиях турбулентного рынка и новых геополитических реалий. Давно назрела необходимость отраслевого импортозамещения в отраслях, перерабатывающих сырье животного происхождения, в мясной промышленности и т.д. Отечественные научные разработки могут найти применение для замещения импортных БАДов, белковых добавок, продуктов с торговой маркой «Коллаген» и т.д.Отдельные разработки автора, связанные со способами получения белковых продуктов запатентованы и подробно в рамках статьи не представлены.Цель настоящей работы: изучить структуру и свойства белковых систем на основе сложных биополимеров и сформировать рекомендации для внедрения отечественных наработок, активно развиваемых в вузах и НИИ на протяжении 30-40 лет.Материалы исследований: белковые системы на основе волокнистых белков, биологически активные белковые добавки. «Коллагены».Методы исследований: вискозиметрия ротационная, оптическая микроскопия, растровая электронная микроскопия (Coxem), элементный микроанализ, математическая обработка данных с расчетом стандартных отклонений, графическая аппроксимация данных испытаний стандартными программными средствами.Результаты: получены отдельные новые данные о структуре, физических, в т.ч. реологических и химических свойствах белковых систем. В частности, реограммы свидетельствовали о нелинейном поведении систем, что позволяет их отнести к псевдопластичным коллоидам. Выполнен анализ элементного состава отдельных белковых систем, что выявило наличие микроэлементов (вследствие влияния сырьевого фактора), функции in vivo не полностью выяснены.Выводы: обоснованы пути решения проблемы сложных, волокнообразующих биополимеров, получены новые данные о структуре и свойствах сырья и продуктов животного происхождения, освещены практические рекомендации по скорейшему применению (по программе импортозамещения) в биотехнологии, пищевых производствах, мясной промышленности, предприятиях по переработке животного сырья.