bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical coherence tomography angiography parameters in patients taking hydroxychloroquine therapy
Authors: Vasilijević Jelena B , Kovačević Igor M. , Dijana Risimić , Dačić Bojana , Marić Gorica , Stanojlović Svetlana 
Published: September 2023

Purpose:
The aim of this study is to measure retinal vessel density and flow rate area by optical coherence tomography angiography (OCTA) in patients with autoimmune diseases taking hydroxychloroquine (HCQ).

Methods:
The cross-sectional study included 98 patients divided into three groups. Group I included patients with the diagnosis of an autoimmune disease, for whom the introduction of HCQ was planned. Group II implied low-risk patients for retinal toxicity (≤5 years of HCQ use), whereas Group III implied patients that were at high-risk (>5 years of drug use). All patients underwent a computerized visual field, central macular thickness by optical coherence tomography, and OCTA measurements.

Results:
The vascular density was found to be statistically significantly decreased in the high-risk group compared to the control group in the superficial parafoveal zone (P = 0.030), whereas it was decreased compared to the low-risk and control groups in the deep layers whole (P = 0.006, P = 0.010, respectively) and perifoveal zones (P = 0.003, P = 0.010, respectively). The foveal avascular zone was significantly enlarged in the high-risk group compared to the control (P < 0.018). Retinal flow rates did not show statistically significant differences between the groups (P > 0.05).

Conclusion:
Patients treated with HCQ for more than 5 appear have a significant loss of vascular density in the parafoveal and perifoveal regions, and FAZ area is significantly increased compared to low-risk patients and controls. These findings indicate that OCTA may be beneficial for monitoring high-risk patients and may stratify their risk of further retinal damage.
Low-grade appendiceal mucinous neoplasms: Histomorphological spectrum in a tertiary care hospital
Authors: Ahuja Manisha , Mandal Shramana , Mallya Varuna , Singh Meeta , Khurana Nita , Lal Pawanindra 
Published: September 2023

ABSTRACT

Background:
Low-grade appendiceal mucinous neoplasms (LAMNs) are benign non-invasive epithelial proliferations of the appendix. These usually present clinically as mucoceles and these rarely exceed 2 cm in diameter. Lesions confined to the lumen are labelled as LAMN; however those in which mucin spreads outside the peritoneum are labeled as pseudomyxoma peritonei (PMP).

Aims and Objective:
A retrospective study was conducted over a period of three years and all cases of appendectomies were studied. Twelve cases of LAMN were identified, which is a diagnostic dilemma for the pathologists and clinicians.

Results:
LAMN was identified based on the histopathological features. Out of the 12 cases, 9 were classified as LAMN and 3 as appendiceal neoplasm with PMP. There was villous or flat proliferation of epithelial lining, loss lymphoid aggregates, and dissecting mucin within muscularis.

Conclusion:
LAMNs are rare neoplasms of the appendix, with clinical presentation similar to acute appendicitis. Mucinous collections within the appendiceal wall should be extensively searched for mucosal changes and, if found, should prompt a careful search for pushing invasion of LAMNs. A thorough and vigilant gross examination can be of great help. Appendicectomy is the treatment of benign and grossly intact mucinous neoplasm.
Accelerated hypofractionated chemoradiation for locally advanced head and neck cancer during COVID 19 pandemic: A tertiary care experience
Authors: Agarwal Sumit , Jaiswal Isha , Shahi Uday P. , Mandal Abhijit , Aggarwal Lalit M. , Singh Ankita , Jaiswal Anil , Yadawa Nandlal 
Published: September 2023

Purpose:
To assess the role of Accelerated Hypofractionated Chemoradiation for Locally Advanced Head & Neck squamous cell cancer (HNSCC) during COVID 19 pandemic.

Materials and Methods:
Previously untreated 20 patients with locally advanced HNSCC (Oral cavity/oropharynx/larynx/hypopharynx) were treated with definitive hypofractionated radiotherapy of 60Gy in 25 fractions with concurrent cisplatin @35 mg/m2 once weekly for 5 weeks from March 2020 to November 2021. The patients were treated on 6MV LINAC with Volumetric modulated arc therapy (VMAT) by the Sequential boost technique and concurrent chemotherapy @35 mg/m2. All the patients received 48Gy in 20 fractions to low-risk volume (CTV LR) in Phase I followed by 12Gy in 5 fractions boost to High-risk volume (CTV HR) in Phase II. The organs at risk (OARs) were contoured and appropriate constraints were given considering the hypofractionated regimen.

Results:
Out of 20 patients, most of the patients were Stage IV (15;75%) & stage III 20%, out of which (55%) 11 were of the oral cavity, (40%) 8 were of the oropharynx, and (5%) 1 of larynx. All patients were treated with 60Gy/25#/5 weeks with the majority of the patients (17;85%) completing their treatment in less than 45 days. The Median follow-up was of 214 days. The locoregional control at 6 Months was 55%. Maximum acute toxicity was grade 3 mucositis which was observed in 18 (90%) patients. Ryle’s tube feeding was needed in 11 (55%) patient. Out of 20 patients, 5 patients did not receive concurrent chemotherapy, and 8 (40%) patients received all 5 cycles of chemotherapy. 7, 35% of the patients could not complete all 5 cycles of concurrent chemotherapy due to grade 3 mucositis.

Conclusion:
During a pandemic crisis with limited manpower & technical resources accelerated hypofractionated radiotherapy with concurrent chemotherapy can be considered a feasible therapeutic option for HNSCC which can significantly reduce the overall Treatment Time (OTT) with comparable local control and manageable toxicities.
Skin appendageal tumors: A 1 year data from a tertiary care institute
Authors: Thakur Mamta , Vijayamohanan Lekshmi , Asotra Sarita 
Published: September 2023

ABSTRACT

Background:
Skin appendageal tumors (SAT) are a rare group of tumors that are classified according to their line of appendageal differentiation along eccrine, apocrine, follicular, and sebaceous lines. However, they are relatively uncommon and create diagnostic difficulties for the pathologist. Recognition of malignant transformation adds to the importance of an accurate diagnosis. A paucity of clinicopathological data from the Himalayan region of India, in particular, prompted the conduct of this study.

Aim:
To study the clinical and histopathological spectrum of SAT during a period of 1 year received at our hospital.

Materials and Methods:
A retrospective study was carried out at the Pathology department of our hospital. All relevant clinical characteristics were noted in addition to the histopathological features. Slides stained with both hematoxylin and eosin and special stains where necessary were used to supplement the diagnoses.

Results:
A total of 17 cases were diagnosed in 1 year (January 2021 to December 2021) at our institute. The predominant age group was 40–59 years. Females outnumbered males, with a male: female ratio of 0.8:1. The most common location of tumors was in the head and neck (90.90%). The majority of cases were benign (90.90%). The majority of tumors were of follicular differentiation (54.55%). We found one malignant tumor of sebaceous differentiation.

Conclusion:
The clinical presentation is remarkably similar to most SAT. In our study, we found that majority of tumors were benign and located in the head and neck. The importance of an accurate histopathological diagnosis is essential in these tumors to diagnose the malignant counterparts and differentiate them from more common skin tumors with different prognoses.
Adipocytokine imbalance and breast cancer in obese women
Authors: Al Qteishat Ahmed , Aringazina Raisa , Ermakov Dmitriy , Demianenko Elena 
Published: September 2023

ABSTRACT

Context:
Breast cancer is the most common diagnosis established in women with malignant tumors.

Aims:
The purpose is to investigate the blood contents of adiponectin and leptin in women with breast cancer and obesity.

Settings and Design:
A total of 140 women aged 40–50 were examined.

Materials and Methods:
Group 1 included 70 women from classes 1 or 2 obesity. Group 2 included 70 women with stage 1 or 2 breast cancer and classes 1 or 2 obesity. The control group included 30 apparently healthy women, with mean age of 42.5 ± 2.5 years.

Statistical Analysis Used:
Statistical processing of the results obtained was performed using Statistica.

Results:
Groups 1 and 2 were statistically significantly different from each other across all parameters, except for leptin resistance. In group 2, the course of breast cancer with concomitant obesity is characterized by disrupted adipocytokine homeostasis, which manifests as a 1.94-fold decrease in the blood content of adiponectin (P < 0.05), a 4.14-fold increase in the blood content of leptin (P < 0.05), and an 8.00-fold increase in the leptin/adiponectin ratio (P < 0.05). Poorly differentiated breast tumors exhibit a more pronounced imbalance in the blood levels of adipocytokines. Thus, the serum content of leptin in women with poorly differentiated tumors (G3) was 1.79 times (P < 0.05) higher than in women with moderately differentiated tumors (G2).

Conclusions:
The course of breast cancer with concomitant obesity is characterized by disrupted adipocytokine homeostasis and decreased adiponectin concentration in the blood.
Trichilemmal carcinoma masquerading as a sebaceous cyst - A rare case report
Authors: Ingale Yaminy Pradeep , Garg Sakshi , Gurwale Sushama , Gore Charusheela R. 
Published: September 2023

ABSTRACT
Trichilemmal carcinoma (TC) is a rare, malignant, cutaneous adnexal neoplasm derived from the external root sheath of hair follicle, commonly seen in elderly males in the seventh to ninth decade. It commonly affects the sun-exposed areas and has an indolent course. We report a case of TC in which a 67-year-old female presented with a swelling on the scalp, which was misdiagnosed as a case of sebaceous cyst. The patient underwent excision and based on histopathological examination and immunohistochemistry, the diagnosis of TC was obtained.
Distortion of the Self-Expandable Stent and Retained Stent Marker: A Rare Complication during Peripheral Angioplasty
Authors: Subrahmanyasarma R. S. Venkata , Koduru Gopalakrishna , Palaparti Raghuram , Parvathaneni Sarada Srinivas Chowdary , Koduru Purnachandra Rao , Ghanta Somasekhar , Boppana Dasarath , Ramakishore Y. , Paluru Manohar Reddy , Maganti Prasad , Sasidhar Y. 
Published: September 2023

Abstract
Long-segment chronic total occlusion in femoropoplitial segment can be effectively treated with self-expandable stent especially when there are flow-limiting dissections created either while wiring the lesion or while predilating the lesions. Distortion of a self-expandable stent can during the procedure; hence, proper care should be taken in Plaque modification before stent deployment. Distortion can cause retention of the stent markers. Understanding the problem, the hardware we are using can guide us in bailing out the situation and also improving the long-term outcomes of the extremities.
Prognoza: Parkinson’s Disease Prediction Using Classification Algorithms
Authors: Shivakoti Mithun , Medaramatla Sai Charan , Godavarthi Deepthi , Shivakoti Narsaiah 
Published: September 2023

Parkinson's Disease (PD) is a persistent neurological condition that has a global impact on a significant number of individuals. The timely detection of PD is imperative for the efficacious treatment and control of the condition. Machine learning (ML) methods have demonstrated significant potential in forecasting Parkinson's disease (PD) based on diverse data sources in recent times. The present research paper outlines a study that employs machine learning [ML]techniques to predict Parkinson's disease. A dataset comprising clinical and demographic characteristics of both patients diagnosed with PD and healthy individuals was taken from Kaggle. The aforementioned dataset was utilized to train and assess multiple machine learning models. The experimental findings indicate that the CatBoost model exhibited superior performance compared to the other models, achieving an accuracy rate of 95.1% and a root mean squared error of of 0.34.In summary, our research showcases the capabilities of machine learning methodologies in forecasting Parkinson's disease and offers valuable insights into the crucial predictors for PD prognosis. The results of our study could potentially contribute to the advancement of diagnostic methods for the timely identification of PD, with increased precision and efficacy.
Background memory‐assisted zero‐shot video object segmentation for unmanned aerial and ground vehicles
Authors: Yun Kimin , Kim Hyung‐Il , Bae Kangmin , Moon Jinyoung 
Published: September 2023

AbstractUnmanned aerial vehicles (UAV) and ground vehicles (UGV) require advanced video analytics for various tasks, such as moving object detection and segmentation; this has led to increasing demands for these methods. We propose a zero‐shot video object segmentation method specifically designed for UAV and UGV applications that focuses on the discovery of moving objects in challenging scenarios. This method employs a background memory model that enables training from sparse annotations along the time axis, utilizing temporal modeling of the background to detect moving objects effectively. The proposed method addresses the limitations of the existing state‐of‐the‐art methods for detecting salient objects within images, regardless of their movements. In particular, our method achieved mean and values of 82.7 and 81.2 on the DAVIS'16, respectively. We also conducted extensive ablation studies that highlighted the contributions of various input compositions and combinations of datasets used for training. In future developments, we will integrate the proposed method with additional systems, such as tracking and obstacle avoidance functionalities.
Viability and adaptability of mestizo female cattle from artificial insemination compared with local
Authors: Seme Kpassi , Somenutse Koffi Ganyo , Coulibaly Fatoumata , Bonfoh Bèdibètè , Kotoe Mensah Délako , Koumessi Léopold Komi , Kossoga Kakom Assota , Pitala Wéré 
Published: September 2023

The objective of this study was to determine after 48 months of age, the growth and viability of crossbreds resulting from Artificial Insemination (AI). The methodology used was the follow-up of 39 crossbreds from IA with 40 local sisters whose births coincided. The data collected concerned the weight of calves, mortalities and their causes. The adaptation of mestizos in the environment was evaluated. The results showed that the weights of Mestizos calves from birth 20.65 ± 6.54 kg (Local x MO) and 23.30 ± 5.34 kg (Local x HO) to three months of age 55.12 ± 4 .95 kg (Local x MO) and 56.65 ± 5.08 kg (Local x HO) was higher (p ≤ 0.05) than those of their local counterparts (17.32 ± 3.74 kg and 42. 05±11.89kg). The pre-weaning mortality rate (18.19%) was higher (p ≤ 0.05) than that obtained in the post-weaning period (11.48%) and is mainly due to calf diarrhea (37 ,30%). The Local x MO crossbreds seem better adapted than those resulting from the Locales x HO in the climatic conditions of Togo in terms of consumption skills and sensitivity to heat. In conclusion, the survival of crossbreeds requires permanent health monitoring and good farm management.
Dépistage biologique de la consommation récente de cannabis chez les patients schizophréniques du Centre Notre Dame de l’Espérance de Bobo-Dioulasso, Burkina Faso
Authors: Da Ollo , Zoungrana Tibaut Joseph , Tall Fatou Gueye , Thiombiano Cherileila , Meda Dimitri , Zongo Emmanuel , Dougouri Yacine Saida , Fofana Souleymane , Bamba Sanata , Siranyan Sélouké , Ouedraogo Georges Anicet 
Published: September 2023

La consommation de cannabis peut entraîner la survenue de troubles psychiatriques ou aggraver des troubles psychiatriques préexistants. L’objectif de cette étude était de dépister une consommation récente du cannabis chez les patients schizophréniques. Il s’est agi d’une étude transversale menée du 15 mai au 15 septembre 2021. Les patients schizophréniques du Centre Notre Dame de l’Espérance (CNDE) de BoboDioulasso ont été inclus. Le sérum obtenu à partir du sang total a été utilisé pour la détermination qualitative in vitro des cannabinoïdes. Le principe du test reposait sur l'interaction cinétique de microparticules en solution (KIMS). Au total, 91 patients schizophréniques ont constitué la population d’étude. Les hommes constituaient 62,63% des patients. L’âge médian des patients était de 39 ans [minimum – maximum: 14 – 73 ans]. Le dépistage des cannabinoïdes a été positif chez 18,68% (17/91) des patients. L’absorbance médiane des échantillons positifs était de 9 mabs avec des extrêmes de 0 mabs à 251 mabs. L’intégration d’un dépistage biologique systématique du cannabis permettrait sans doute une meilleure prise en charge des patients atteints de troubles mentaux.

English title: Biological screening of recent cannabis use among schizophrenic patients at the Centre Notre Dame de l'Espérance in Bobo-Dioulasso, Burkina Faso
Cannabis abuse may lead to the onset of psychiatric disorders or exacerbate pre-existing psychiatric disorders. The objective of this study was to screen for recent cannabis use in patients with schizophrenia. This was a cross-sectional study performed from 15 May to 15 September 2021. Schizophrenic patients at the Centre Notre Dame de l'Espérance (CNDE) in Bobo-Dioulasso were included. Serum obtained from whole blood was used for the in vitro qualitative determination of cannabinoids based on the kinetic interaction of microparticles in solution (KIMS). A total of 91 schizophrenic patients were included in the study population. Men constituted 62.63% of the patients. The Median age of the patients was 39 years [minimum – maximum: 14 – 73 years]. Cannabinoid screening was positive in 18.68% (17/91) patients. Median absorbance of positive samples was 9 mabs with extremes from 0 mabs to 251 mabs. Systematic biological screening for canabinoid would allow a better management of patients with mental disorders.
Potentiel thérapeutique et nutritionnel de quelques échantillons de thé vert consommé dans la région de Dakar au Sénégal
Authors: Naco Mohamed El Bechir , Tirera Harouna , Tangara Benoit Yaranga , Sarr Serigne Omar , Fall Djibril , Diop Yerim Mbagnick , Ndiaye Bara , Diop Amadou 
Published: September 2023

Le thé vert (Camellia sinensis) est une boisson largement consommée au Sénégal en de multiples occasions comme les rencontres religieuses ou politiques, les cérémonies familiales (mariage, baptême, funérailles…). Ainsi l’objectif général de cette étude était de contribuer à une meilleure connaissance de la qualité nutritionnelle et du potentiel thérapeutique du thé vert vendu dans le marché dakarois. Les teneurs en éléments minéraux, en alcaloïdes, en composés phénoliques et en flavonoïdes de huit échantillons de thé vert ont été déterminées par Spectrophotométrie. La méthode AOAC (Association of Official Analytical Chemists) (1990) a également été utilisée. Par ailleurs, une évaluation du pouvoir antioxydant d’extraits d’échantillons de thé a été faite selon la méthode au DDPH. Les résultats des analyses a montré que dans tous les échantillons le potassium était l’élément minéral majoritaire avec une teneur de 1351,34 ± 0,052 mg/100 g tandis que la plus faible valeur a été obtenue avec le cuivre (0,17 ± 0,004 mg/100 g). Les teneurs en alcaloïdes totaux variaient entre 0,71 ± 0,0010 g et 0,32 ± 0,0020 g tandis que celles en polyphénols totaux étaient comprises entre 103,18 mg et 67,14mg. La teneur en flavonoïdes totaux la plus élevée dans le thé vert était de 49,31 mg et la plus faible était de 33,68 mg. Les extraits de thé ont montré une activité antioxydante modérée avec une CI₅₀ minimal de 3,1 ± 0,016 mg/mL comparativement à l’acide ascorbique (CI₅₀ = 0,09 ± 0,002 mg/mL) utilisé comme standard. Cette étude nous a permis de montrer que nos échantillons de thé vert sont riches en éléments minéraux (potassium, sodium, calcium, magnésium, fer, zinc, et cuivre) et en composés phytochimiques (alcaloïdes, flavonoïdes, polyphénols totaux). Ce qui pourrait expliquer leur large consommation dans la région dakaroise et forte qualité antioxydante.
Etude ethnobotanique des plantes utilisées dans le traitement des troubles du système nerveux dans la médecine traditionnelle au Togo
Authors: Doumongue Tibanguebé , Koula Fo-doh Clefasse , Bledu Koffi Mawufemo , Gbekley Efui Holaly , Effoe Stéphane , Hoekou Yao Patrick , Donyoh Kossi , Batawila Komlan , Karou Damintoti Simplice , Tchacondo Tchadjobo 
Published: September 2023

La médecine traditionnelle prend en charge diverses maladies, dont celles affectant le système nerveux, en faisant habituellement recours aux espèces végétales. L’objectif de cette étude était de recenser les plantes utilisées en médecine traditionnelle pour le traitement des troubles neuropsychiatriques. Une enquête ethnobotanique dans les régions Maritime et Savanes (Togo) basée sur des entretiens semi-structurés avait enrôlée 103 professionnels des plantes. Les données de l’enquête avaient permis d’identifier 21 espèces végétales regroupées en 17 familles. La famille des Bignoniaceae était la mieux représentée avec trois espèces. On note une forte utilisation de Rauvolfia vomitoria (55,34%). Les racines (55%), les écorces de racines (18%) et les feuilles (17%) étaient les plus sollicitées. La principale méthode de préparation est la décoction (48%). Les professionnels des plantes des régions maritimes et des savanes du Togo ont des connaissances diversifiées sur la biodiversité et ses vertus thérapeutiques.

Englsih title: Ethnobotanical survey of plants used in the treatment of nervous system disorders in traditional medicine in Togo
Traditional medicine treats various diseases, including those affecting the nervous system, usually using plant species. The objective of this study was to identify the plants used in traditional medicine for the treatment of neuropsychiatric disorders. An ethnobotanical survey in the Maritime and Savanes regions (Togo) based on semi-structured interviews enrolled 103 plant professionals. The survey data identified 21 plant species grouped into 17 families. The Bignoniaceae family was the best represented with three species. There was a strong use of Rauvolfia vomitoria (55.34%). Roots (55%), root bark (18%) and leaves (17%) were the most stressed. The main method of preparation was decoction (48%). The plant professionals of Togo have diversified knowledge on biodiversity and its therapeutic virtues.
Activité analgésique et phytochimie des extraits aqueux du fruit de <i>Dacryodes edulis</i> (G. Don) H. J. Lam. (Burseraceae) chez la souris
Authors: Ossibi G.J. Etou , Ossibi A.W. Etou , Mpika J. , Lingomo B.S. Wossolo , Attibayeba  
Published: September 2023

Le safoutier (Dacryodes edulis (G. Don) H.J. Lam est un arbre fruitier oléifère de la famille des Burseraceae et ses fruits comestibles sont appelés safous. L’évaluation des teneurs en flavonoïdes totaux, en polyphénols totaux et en tanins totaux dans les mésocarpes et dans les graines de fruits à maturité gustative a été faite à partir des dosages au spectrophotomètre. L’activité antalgique des extraits aqueux de la pulpe et des graines de fruits Dacryodes edulis à maturité gustative a été évaluée chez la souris sur la douleur induite par l’acide acétique 0,6%. Les résultats obtenus ont révélé la richesse de des fruits de safoutier en ces composés qui s’accumulent dans la graine et dans le mésocarpe. L’extrait aqueux de la graine est plus riche en composés phénoliques que celui du mésocarpe contre 1456 à 862 mg EG/gE pour les flavonoides totaux, 698 à 238 mg EQ/gE en polyphénols totaux et 701 à 578 mg EQ/gE en tanins totaux. Concernant l’activité antalgique, il ressort que les extraits aqueux des deux parties du fruit de safoutier réduisent significativement le nombre de crampes abdominales chez la souris. L’activité analgésique est due à la présence dans les fruits de D. edulis des composés phénoliques