bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals
Authors: Meng Zhijun , Zhang Zhen , Zhao Jianli , Liu Caihong , Yao Peng , Zhang Ling , Xie Dina , Lau Wayne Bond , Tsukuda Jumpei , Christopher Theodore A. , Lopez Bernard , Zhu Di , Liu Demin , Zhang John Ry , Gao Erhe , Ischiropoulos Harry , Koch Walter , Ma Xinliang , Wang Yajing 
Published: March 2023

Background:
Myocardial insulin resistance is a hallmark of diabetic cardiac injury. However, the underlying molecular mechanisms remain unclear. Recent studies demonstrate that the diabetic heart is resistant to other cardioprotective interventions, including adiponectin and preconditioning. The “universal” resistance to multiple therapeutic interventions suggests impairment of the requisite molecule(s) involved in broad prosurvival signaling cascades. Cav (Caveolin) is a scaffolding protein coordinating transmembrane signaling transduction. However, the role of Cav3 in diabetic impairment of cardiac protective signaling and diabetic ischemic heart failure is unknown.

Methods:
Wild-type and gene-manipulated mice were fed a normal diet or high-fat diet for 2 to 12 weeks and subjected to myocardial ischemia and reperfusion. Insulin cardioprotection was determined.

Results:

Compared with the normal diet group, the cardioprotective effect of insulin was significantly blunted as early as 4 weeks of high-fat diet feeding (prediabetes), a time point where expression levels of insulin-signaling molecules remained unchanged. However, Cav3/insulin receptor-β complex formation was significantly reduced. Among multiple posttranslational modifications altering protein/protein interaction, Cav3 (not insulin receptor-β) tyrosine nitration is prominent in the prediabetic heart. Treatment of cardiomyocytes with 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride reduced the signalsome complex and blocked insulin transmembrane signaling. Mass spectrometry identified Tyr
73
as the Cav3 nitration site. Phenylalanine substitution of Tyr
73
(Cav3
Y73F
) abolished 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride–induced Cav3 nitration, restored Cav3/insulin receptor-β complex, and rescued insulin transmembrane signaling. It is most important that adeno-associated virus 9–mediated cardiomyocyte-specific Cav3
Y73F
reexpression blocked high-fat diet–induced Cav3 nitration, preserved Cav3 signalsome integrity, restored transmembrane signaling, and rescued insulin-protective action against ischemic heart failure. Last, diabetic nitrative modification of Cav3 at Tyr
73
also reduced Cav3/AdipoR1 complex formation and blocked adiponectin cardioprotective signaling.

Conclusions:

Nitration of Cav3 at Tyr
73
and resultant signal complex dissociation results in cardiac insulin/adiponectin resistance in the prediabetic heart, contributing to ischemic heart failure progression. Early interventions preserving Cav3-centered signalsome integrity is an effective novel strategy against diabetic exacerbation of ischemic heart failure.
The Coupling Between Tropical Meteorology, Aerosol Lifecycle, Convection, and Radiation during the Cloud, Aerosol and Monsoon Processes Philippines Experiment (CAMP2Ex)
Authors: Reid J. S. , Maring H. B. , Narisma G. T. , van den Heever S. , Di Girolamo L. , Ferrare R. , Lawson P. , Mace G. G. , Simpas J. B. , Tanelli S. , Ziemba L. , van Diedenhoven B. , Bruintjes R. , Bucholtz A. , Cairns B. , Cambaliza M. O. , Chen G. , Diskin G. S. , Flynn J. H. , Hostetler C. A. , Holz R. E. , Lang T. J. , Schmidt K. S. , Smith G. , Sorooshian A. , Thompson E. J. , Thornhill K. L. , Trepte C. , Wang J. , Woods S. , Yoon S. , Alexandrov M. , Alvarez S. , Amiot C. G. , Bennett J. R. , Brooks M. , Burton S. P. , Cayanan E. , Chen H. , Collow A. , Crosbie E. , DaSilva A. , DiGangi J. P. , Flagg D. D. , Freeman S. W. , Fu D. , Fukada E. , Hilario M. R. A. , Hong Y. , Hristova-Veleva S. M. , Kuehn R. , Kowch R. S. , Leung G. R. , Loveridge J. , Meyer K. , Miller R. M. , Montes M. J. , Moum J. N. , Nenes A. , Nesbitt S. W. , Norgren M. , Nowottnick E. P. , Rauber R. M. , Reid E. A. , Rutledge S. , Schlosser J. S. , Sekiyama T. T. , Shook M. A. , Sokolowsky G. A. , Stamnes S. A. , Tanaka T. Y. , Wasilewski A. , Xian P. , Xiao Q. , Xu Zhuocan , Zavaleta J. 
Published: March 2023

Abstract
The NASA Cloud, Aerosol, and Monsoon Processes Philippines Experiment (CAMP2Ex) employed the NASA P-3, Stratton Park Engineering Company (SPEC) Learjet 35, and a host of satellites and surface sensors to characterize the coupling of aerosol processes, cloud physics, and atmospheric radiation within the Maritime Continent’s complex southwest monsoonal environment. Conducted in the late summer of 2019 from Luzon, Philippines, in conjunction with the Office of Naval Research Propagation of Intraseasonal Tropical Oscillations (PISTON) experiment with its R/V Sally Ride stationed in the northwestern tropical Pacific, CAMP2Ex documented diverse biomass burning, industrial and natural aerosol populations, and their interactions with small to congestus convection. The 2019 season exhibited El Niño conditions and associated drought, high biomass burning emissions, and an early monsoon transition allowing for observation of pristine to massively polluted environments as they advected through intricate diurnal mesoscale and radiative environments into the monsoonal trough. CAMP2Ex’s preliminary results indicate 1) increasing aerosol loadings tend to invigorate congestus convection in height and increase liquid water paths; 2) lidar, polarimetry, and geostationary Advanced Himawari Imager remote sensing sensors have skill in quantifying diverse aerosol and cloud properties and their interaction; and 3) high-resolution remote sensing technologies are able to greatly improve our ability to evaluate the radiation budget in complex cloud systems. Through the development of innovative informatics technologies, CAMP2Ex provides a benchmark dataset of an environment of extremes for the study of aerosol, cloud, and radiation processes as well as a crucible for the design of future observing systems.
Verification of Rapid Refresh and High-Resolution Rapid Refresh Model Variables in Tornadic Tropical Cyclones
Authors: MacDonald Leland M. , Nowotarski Christopher J. 
Published: March 2023

Abstract
Tropical cyclone tornadoes (TCTORs) are a hazard to life and property during landfalling tropical cyclones (TCs). The threat is often spread over a wide area within the TC envelope and must be continually evaluated as the TC moves inland and dissipates. To anticipate the risk of TCTORs, forecasters may use high-resolution, rapidly updating model analyses and short-range forecasts such as the Rapid Refresh (RAP) and High-Resolution Rapid Refresh (HRRR), and an ingredients-based approach similar to that used for forecasting continental midlatitude tornadoes. Though RAP and HRRR errors have been identified in typical midlatitude convective environments, this study evaluates the performance of the RAP and the HRRR within the TC envelope, with particular attention given to sounding-derived parameters previously identified as useful for TCTOR forecasting. A sample of 1730 observed upper-air soundings is sourced from 13 TCs that made landfall along the U.S. coastline between 2017 and 2019. The observed soundings are paired with their corresponding model gridpoint soundings from the RAP analysis, RAP 12-h forecast, and HRRR 12-h forecast. Model errors are calculated for both the raw sounding variables of temperature, dewpoint, and wind speed, as well as for the selected sounding-derived parameters. Results show a moist bias that worsens with height across all model runs. There are also statistically significant underpredictions in stability-related parameters such as convective available potential energy (CAPE) and kinematic parameters such as vertical wind shear.
Vulnerability in a Tropical Cyclone Risk Model: Philippines Case Study
Authors: Baldwin Jane W. , Lee Chia-Ying , Walsh Brian J. , Camargo Suzana J. , Sobel Adam H. 
Published: March 2023

Abstract
The authors describe a tropical cyclone risk model for the Philippines using open-source methods that can be straightforwardly generalized to other countries. Wind fields derived from historical observations, as well as those from an environmentally forced tropical cyclone hazard model, are combined with data representing exposed value and vulnerability to determine asset losses. Exposed value is represented by the LitPop dataset, which assumes total asset value is distributed across a country following population density and night-lights data. Vulnerability is assumed to follow a functional form previously proposed by Emanuel, with free parameters chosen by a sensitivity analysis in which simulated and historical reported damages are compared for different parameter values and further constrained by information from household surveys about regional building characteristics. Use of different vulnerability parameters for the region around Manila, Philippines, yields much better agreement between simulated and actually reported losses than does a single set of parameters for the entire country. Despite the improvements from regionally refined vulnerability, the model predicts no losses for a substantial number of destructive historical storms, a difference the authors hypothesize is due to the use of wind speed as the sole metric of tropical cyclone hazard, omitting explicit representation of storm surge and/or rainfall. Bearing these limitations in mind, this model can be used to estimate return levels for tropical cyclone–caused wind hazards and asset losses for regions across the Philippines, relevant to some disaster risk reduction and management tasks; this model also provides a platform for further development of open-source tropical cyclone risk modeling.

Significance Statement
Landfalling tropical cyclones are devastating disasters for which the Philippines is particularly at risk. Here we develop a model for tropical cyclone risk, quantified as property losses, over the Philippines and demonstrate its effectiveness by comparing to historical damages. We find that capturing the difference in vulnerability between the largest city in the Philippines (Manila) and more rural areas is important to accurately represent this risk. Using this model, we can more accurately constrain the risk of very extreme tropical cyclone events in the Philippines. The model can also be straightforwardly adapted for emergency planning in other countries and for climate change scenarios using openly available information.
Validation and Comparison of the Prognosis Predicting Ability of Inflammation-Based Scores Following Endovascular Treatment for Peripheral Artery Disease
Authors: Itagaki Tadashi , Ebisawa Soichiro , Kato Tamon , Miura Takashi , Oyama Yushi , Hashizume Naoto , Yokota Daisuke , Taki Minami , Senda Keisuke , Okina Yoshiteru , Wakabayashi Tadamasa , Fujimori Kouki , Karube Kenichi , Sakai Takahiro , Nomoto Fumika , Takamatsu Toshifumi , Tanaka Kiu , Mochidome Tomoaki , Saigusa Tatsuya , Motoki Hirohiko , Kasai Toshio , Ikeda Uichi , Kuwahara Koichiro 
Published: March 2023

We assessed the prognostic ability of several inflammation-based scores and compared their long-term outcomes in patients with peripheral artery disease (PAD) following endovascular treatment (EVT). We included 278 patients with PAD who underwent EVT and classified them according to their inflammation-based scores (Glasgow prognostic score [GPS], modified GPS [mGPS], platelet to lymphocyte ratio [PLR], prognostic index [PI], and prognostic nutritional index [PNI]). Major adverse cardiovascular events (MACE) at 5 years were examined, and C-statistics in each measure were calculated to compare their MACE predictive ability. During the follow-up period, 96 patients experienced MACE. Kaplan–Meier analysis showed that higher scores of all measures were associated with a higher MACE incidence. Multivariate Cox proportional hazard analysis showed that GPS 2, mGPS 2, PLR 1, and PNI 1, compared with GPS 0, mGPS 0, PLR 0, and PNI 0, were associated with an increased risk of MACE. C-statistics for MACE for PNI (.683) were greater than those for GPS (.635, P = .021), mGPS (.580, P = .019), PLR (.604, P = .024), and PI (.553, P < .001). PNI is associated with MACE risk and has a better prognosis-predicting ability than other inflammation-scoring models for patients with PAD following EVT.
Nasal Presentations of Rosai–Dorfman Disease: Clinical Manifestation and Treatment Outcomes
Authors: Xu Haoyuan , Zhang Huankang , Li Wanpeng , Zhang Chen , Wang Huan , Wang Dehui 
Published: March 2023

Purpose There has been a lack of evidence-based management strategies on the nasal presentations of Rosai–Dorfman disease (RDD). We aim to investigate the clinical manifestation, treatment, and outcomes in patients with nasal RDD. Methods We retrospectively reviewed available medical records of patients diagnosed with nasal RDD from 2014 to 2021 at our department. Results A total of 26 patients were included with a marked female preponderance (2.25:1). The most common symptom and affected sites were nasal congestion (31%) and nasal cavity (73%), respectively. The average times of biopsies was 1.5 times (range: 1–3). The histiocytes were positive about S100 and CD68 and negative for CD1a with common emperipolesis. The mean duration of follow-up was 34 months (range, 3–87). One patient with concomitant nasal small B-cell lymphoma achieved complete remission after chemoradiotherapy. Recommended treatments were endoscopic resection (92%) and oral corticosteroids (21%). Surgery was performed to remove the resectable lesion as completely as possible. Corticosteroids induced almost 100% overall remission. Of the relapses, two patients achieved an overall response and one remained in progressive stage after subsequent excision. Two patients only received dissection biopsy that responded to oral corticosteroid administration and combined therapies of lenalidomide and dexamethasone, respectively. Conclusions Diffuse lesions in nasal cavity and sinuses, and even widely affected nasal skull base, laryngopharynx, orbit, and cavernous sinus, should be considered the possibility of Rosai–Dorfman disease. Characteristic immunohistochemical staining is helpful for the diagnosis. Endoscopic surgical therapy remains the mainstream treatment for patients enduring an unbearable course. Oral corticosteroid administration serves as an adjuvant therapy for first-line treatments.
Hidden Structures: How Knowledge of New Practices Moves Among Educators in One Rural School District
Authors: Karnopp Jennifer R. 
Published: March 2023

Background/Context: Rural districts often struggle to provide organizational structures that support knowledge-building and sharing among educators, contributing to the challenge of change implementation in rural contexts. Although prior scholarship identifies social relationships centered on trust as important for fostering educator learning, we know little about how knowledge regarding a change initiative moves through a district lacking formal organizational learning supports and the role that informal relationships may play in fostering educator knowledge-building for organizational learning in an under-resourced rural context. Purpose/Objective/Research Question/Focus of Study: This article explores the network of knowledge related to a recent change initiative in a rural district striving to implement new instructional practices. Of particular interest is how knowledge is created and shared among educators and the role that organizational structures and informal relationships play in educators’ knowledge-building and sharing processes. Research Design: I present a conceptual model that brings together knowledge-creation and structuration theories. Using a sequential mixed methods design, I examine the information and advice interactions and knowledge-building experiences of educators in one rural school district. Analytical methods include social network analysis of survey data and thematic analysis of interview data. Conclusions/Recommendations: Findings suggest that informal relationships were consequential to organizational learning in this district with few formally designated learning supports, though friendship relationships were not consequential. Instead, knowledge-building interactions occurred when individual educators had a positive prior relationship; when mundane organizational structures, such as the master schedule and the assignment of informal or extracurricular roles, facilitated informal interactions; and when educators were motivated to engage in such interactions. This article makes three important contributions to our understandings of organizational learning in this under-resourced rural district context: (1) through mundane organizational structures, principals influence informal knowledge interactions; (2) educator agency is critical for change implementation; and (3) recursive educator interactions may constitute an informal organizational learning structure. This informal structure supporting organizational learning that was invisible to school leadership—fed by recursive informal interactions and supported by mundane organizational structures—represents a fertile area for future research.
Subacromial Balloon Spacer Implantation for Massive Irreparable Rotator Cuff Tears Is Associated With Restoration of the Acromiohumeral Interval and Glenohumeral Center of Pressure: A Systematic Review and Meta-Analysis of Controlled Laboratory Studies
Authors: Kunze Kyle N. , Moran Jay , Taylor Samuel A. , Fu Michael C. , Rodeo Scott A. , Warren Russell F. , Dines David M. , Gulotta Lawrence V. , Dines Joshua S. 
Published: March 2023

Background: Biodegradable subacromial balloon spacers (SBSs) have become increasingly used for the treatment of massive irreparable rotator cuff tears given their theorized clinical benefits; however, the relationship between biomechanical functions of the balloon spacer and clinical benefits remains unclear. Purpose: To perform a systematic review and meta-analysis of controlled laboratory studies investigating the use of SBSs for massive irreparable rotator cuff tears. Study Design: Systematic review and meta-analysis; Level of evidence, 4. Methods: PubMed, OVID/Medline, and Cochrane databases were queried in July 2022 for biomechanical data pertaining to SBS implantation in cadaveric models of irreparable rotator cuff tears. Random-effects meta-analysis of continuous outcomes using the DerSimonian-Laird method was performed to estimate pooled-treatment effect sizes between the irreparable rotator cuff tear state and the state in which an SBS was implanted. Data reported variably or in formats not amenable to analysis were presented descriptively. Results: Five studies involving 44 cadaveric specimens were included. At 0° of shoulder abduction, SBS implantation resulted in a mean inferior humeral head translation of 4.80 mm (95% CI, 3.20-6.40; P < .001) relative to the irreparable rotator cuff tear state. This decreased to 4.39 mm and 4.35 mm at 30° and 60° of abduction, respectively. At 0° of abduction, implantation of an SBS was associated with a 5.01-mm (95% CI, 3.56-6.46, P < .001) anterior translation of the glenohumeral center of contact pressure relative to the irreparable tear state. This translation changed to 5.11 mm and 5.49 mm at 30° and 60° of abduction. In 2 studies, SBS implantation restored the glenohumeral contact pressure to that of the intact state and significantly reduced subacromial pressure distribution over a rotator cuff repair state. In 1 study, a high balloon fill volume (40 mL) resulted in a significant 10.3 ± 1.4–mm more anterior humeral head position relative to the intact cuff state. Conclusion: SBS implantation in cadaveric models of irreparable rotator cuff tears results in significant improvements in humeral head position at 0°, 30°, and 60° of shoulder abduction. Balloon spacers may also improve glenohumeral and subacromial contact pressures, although insufficient evidence currently exists to corroborate these findings. High balloon fill volumes (40 mL) may confer supraphysiologic anteroinferior translation of the humeral head.
Vitamin D Insufficiency is Associated with Higher Incidence of Dementia, a Large Community-Based Retrospective Cohort Study
Authors: Kiderman David , Ben-Shabat Niv , Tsur Avishai M. , Anis Saar , Watad Abdulla , Cohen Arnon D. , Paz Ziv , Amital Howard 
Published: March 2023

Introduction Active metabolite of vitamin D has neuro-immunomodulatory and neuroprotective properties. However, there is still a debate about the potential association between low serum levels of hydroxy-vitamin D and increased risk for dementia. Objectives To determine an association between hypovitaminosis D and dementia for different 25-hydroxyvitamin-D (25(OH)D) serum level cutoffs. Methods Patients were identified utilizing the database of Clalit Health Services (CHS), the largest healthcare provider in Israel. For each subject, all available values of 25(OH)D during the study period, which lasted from 2002 to 2019, were obtained. Rates of dementia were compared across different cutoffs of 25(OH)D levels. Results Cohort included 4278 patients, of whom 2454 (57%) were women. The mean age at the beginning of follow-up was 53 (±17). During the 17-year study period, a total of 133 patients (3%) were diagnosed with dementia. In a fully adjusted multivariate analysis, the risk for dementia was almost 2-fold higher in patients with an average of vitamin D insufficiency (<75 nmol/l) measurements (OR = 1.8, 95% C.I. = 1.0-3.2) compared to reference values (≥75 nmol/l). Patients with vitamin D deficiency (<50 nmol/l) demonstrated higher rates of dementia (OR = 2.6, 95% C.I. = 1.4-4.8). In our cohort, patients were diagnosed with dementia at a younger age in the deficiency (77 vs. 81 P-value = 0.05) and the insufficiency groups (77 vs. 81 P-value = 0.05) compared to the reference values (≥75 nmol/l). Conclusion Insufficient levels of vitamin D are associated with dementia. Dementia is diagnosed at a younger age in patients with insufficient and deficient vitamin D levels.
Finnish Translation and Linguistic Validation of the CLEFT-Q Questionnaire
Authors: Westerlund Mikael , Heliövaara Arja , Leikola Junnu , Homsy Pauliina 
Published: March 2023

Objective Cleft lip and/or palate (CL/P) can have long-lasting effects on the appearance, function, and psychosocial wellbeing of patients. The CLEFT-Q questionnaire is a patient-reported outcomes instrument specifically designed to assess the health-related quality of life of patients with CL/P. The aim of this study was to produce and linguistically validate a Finnish version of the CLEFT-Q questionnaire. Design The CLEFT-Q questionnaire was translated into Finnish following guidelines of the International Society for Pharmacoeconomics and Outcomes Research. Pilot testing with cognitive debriefing interviews was conducted on patients of the target age range of the questionnaire, 8–29, and with various cleft types. Results The CLEFT-Q questionnaire translated readily into Finnish. A review of the backward translation led to two words being changed. Thirteen patients – ten females and three males – with a median age of 14 years, participated in the cognitive debriefing interviews. The interviews led to further nine word changes. The pilot study data suggested that the performance of the Finnish version of the instrument is in line with the original CLEFT-Q questionnaire. Conclusions The Finnish version of CLEFT-Q produced here is linguistically valid and ready for use in the evaluation of the health-related quality of life of patients with CL/P. However, future work is needed to further assess the validity and the reliability of the CLEFT-Q in the Finnish patient population.