bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibacterial activity of barbatimão (Stryphnodendron adstringens) against periodontopathogens and cytotoxic effects on fibroblasts
Authors: de Melo Raquel N , de Goes Vivian F F , Canelli Amanda P , de Aro Andrea A , Moreira Bruno O , Correia Jennifer R , Catirse Alma B C E B , dos Reis Andréa C , Costa Sérgio Marques , de Godoi Ana P T 
Published: June 2023

Abstract
This in vitro study aimed to evaluate the growth-inhibitory effects against periodontal disease-causing bacteria and cytotoxic effects against mouse fibroblast cells of the Stryphnodendron adstringens (barbatimão) hydroalcoholic extract. The contents of phenols and tannins in the extract were determined. The growth-inhibitory activity of the barbatimão was evaluated by determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The viability of fibroblast cells was analyzed using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assay at 24 and 48 h post-treatment. The MIC values of the extract against Prevotella intermedia, Porphyromonas gingivalis, and Fusobacterium nucleatum were 0.05, 0.125, and 2 mg mL−1, respectively, while the MBC values were 4, 2, and 2 mg mL−1, respectively. The viability rate of barbatimão (0.25 mg mL−1)-treated L929 cells was higher than that of chlorhexidine (0.12%)-treated L929 cells at 48 h post-treatment. The contents of total phenolics and total tannins in the extract were 837.39 ± 0.10 and 785.82 ± 0.14 mg of tannic acid equivalent per gram of the extract, respectively. These findings indicate that the barbatimão hydroalcoholic extract, which exerted potent growth-inhibitory effects against the test microbial species and low cytotoxic effects on fibroblasts, has potential applications in the development of novel mouthwash products.
A logical framework to model software development by multiple agents following a common specification
Authors: Pitsiladis Georgios V , Stefaneas Petros S 
Published: June 2023

Abstract
In this paper, we address modelling program development by multiple different programmers (or programming teams) who work in different settings (programming languages or reasoning frameworks) but follow a common specification. After consideration of some philosophical issues regarding program development, including its similarities and dissimilarities with scientific theorizing, we extend a logical framework built to describe scientific theorizing in relativist settings: our extensions add the ability of reasoning about programs, the iterative process of their generation and their specifications. We are thus able to use the framework in order to make a first step towards examining at an abstract level the problem of translatability between the programs produced by program generators, by defining a notion of translation between the outputs of program generators and proving that there is such a (trivial) translation when two program generators follow the same specification reliably (in a specific sense of reliability).
Decomposition approaches for scheduling chronic outpatients’ clinical pathways in Answer Set Programming
Authors: Cappanera Paola , Gavanelli Marco , Nonato Maddalena , Roma Marco 
Published: June 2023

Abstract
Chronic patients suffering from non-communicable diseases are often enrolled into a diagnostic and therapeutic care program featuring a personalized care plan. Healthcare is mostly provided at the patient’s home, but those examinations and treatments that must be delivered at the hospital have to be explicitly booked. Booking is not trivial due to, on the one hand, the several time constraints that become particularly tight in the case of comorbidity, on the other hand, the limited availability of both staff and equipment at the hospital care units. This suggests that the scheduling of the clinical pathways for enrolled outpatients should be managed in a centralized manner, taking advantage of the fact that demand for services is known well in advance. The aim is to serve as many requests as possible (unattended requests are supplied by contracted private health facilities) in a timely manner, taking patients priority into account. Booking involves setting a date and a time for each selected health service, which is rather complex. In this work, we provide a declarative approach by encoding the problem in Answer Set Programming (ASP). In order to improve the scalability of the ASP approach, we present and compare two heuristic approaches, respectively based on service demand and time decomposition. All approaches are tested on instances of increasing size to assess scalability with respect to time horizon and number of requests.
Assessing the safety profile of voriconazole use in suspected COVID-19-associated pulmonary aspergillosis–a two-centre observational study
Authors: Costa-Pinto Rahul , Klink Sarah , Rotherham Hannah , Perera Padeepa , Finlay Liam , Urbancic Karen , Vaz Karl , Trubiano Jason , Bellomo Rinaldo 
Published: June 2023

Abstract
The decision to use voriconazole for suspected COVID-19-associated pulmonary aspergillosis (CAPA) is based on clinical judgement weighed against concerns about its potential toxicity. We assessed the safety profile of voriconazole for patients with suspected CAPA by conducting a retrospective study of patients across two intensive care units. We compared changes in any liver enzymes or bilirubin and any new or increasing corrected QT interval (QTc) prolongation following voriconazole use to patient baseline to indicate possible drug effect.
In total, 48 patients with presumed CAPA treated with voriconazole were identified. Voriconazole therapy was administered for a median of 8 days (interquartile range [IQR] 5–22) and the median level was 1.86 mg/L (IQR 1.22–2.94). At baseline, 2% of patients had a hepatocellular injury profile, 54% had a cholestatic injury profile, and 21% had a mixed injury profile. There were no statistically significant changes in liver function tests over the first 7 days after voriconazole initiation. At day 28, there was a significant increase in alkaline phospahte only (81–122 U/L, P = 0.006), driven by changes in patients with baseline cholestatic injury. In contrast, patients with baseline hepatocellular or mixed injury had a significant decrease in alanine transaminase and aspartate transaminase. Baseline QTc was 437 ms and remained unchanged after 7 days of voriconazole therapy even after sensitivity analysis for concomitantly administered QT prolonging agents.
Therefore, at the doses used in this study, we did not detect evidence of significant liver or cardiac toxicity related to voriconazole use. Such information can be used to assist clinicians in the decision to initiate such treatment.
Evidence of anti-Hcp100 antibodies in COVID-19 critically ill patients with detectable anti-histoplasmin antibodies in a highly endemic area for histoplasmosis
Authors: Toscanini María A , Barberis Fernanda , Benedetti Fernanda , Rodríguez Laboccetta Carolina , Videla Garrido Agustín , Fernández Briceño Víctor , Posse Gladys B , Capece Paula , Nusblat Alejandro D , Cuestas María L 
Published: June 2023

Abstract
Patients with severe COVID-19 are at increased risk for invasive fungal infections, which are underestimated. Histoplasmosis reactivation in endemic areas should not be overlooked in this population. In a previous study, seroconversion to anti-histoplasmin antibodies by ELISA was detected in 6/39 (15.4%) patients with severe COVID-19. In this work, samples were further investigated to detect seroconversion to antibodies against the Histoplasma capsulatum 100-kDa antigen (Hcp100) by ELISA. Seroconversion to anti-Hcp100 antibodies was detected in 7/39 patients, of whom 6 also seroconverted anti-histoplasmin antibodies. These results reinforce previous findings that show histoplasmosis as an underdiagnosed fungal entity complicating COVID-19.
TESS and CHEOPS discover two warm sub-Neptunes transiting the bright K-dwarf HD 15906
Authors: Tuson A , Queloz D , Osborn H P , Wilson T G , Hooton M J , Beck M , Lendl M , Olofsson G , Fortier A , Bonfanti A , Brandeker A , Buchhave L A , Collier Cameron A , Ciardi D R , Collins K A , Gandolfi D , Garai Z , Giacalone S , Gomes da Silva J , Howell S B , Patel J A , Persson C M , Serrano L M , Sousa S G , Ulmer-Moll S , Vanderburg A , Ziegler C , Alibert Y , Alonso R , Anglada G , Bárczy T , Barrado Navascues D , Barros S C C , Baumjohann W , Beck T , Benz W , Billot N , Bonfils X , Borsato L , Broeg C , Cabrera J , Charnoz S , Conti D M , Csizmadia Sz , Cubillos P E , Davies M B , Deleuil M , Delrez L , Demangeon O D S , Demory B-O , Dragomir D , Dressing C D , Ehrenreich D , Erikson A , Essack Z , Farinato J , Fossati L , Fridlund M , Furlan E , Gill H , Gillon M , Gnilka C L , Gonzales E , Güdel M , Günther M N , Hoyer S , Isaak K G , Jenkins J M , Kiss L L , Laskar J , Latham D W , Law N , Lecavelier des Etangs A , Curto G Lo , Lovis C , Luque R , Magrin D , Mann A W , Maxted P F L , Mayor M , McDermott S , Mecina M , Mordasini C , Mortier A , Nascimbeni V , Ottensamer R , Pagano I , Pallé E , Peter G , Piotto G , Pollacco D , Pritchard T , Ragazzoni R , Rando N , Ratti F , Rauer H , Ribas I , Ricker G R , Rieder M , Santos N C , Savel A B , Scandariato G , Schwarz R P , Seager S , Ségransan D , Shporer A , Simon A E , Smith A M S , Steller M , Stockdale C , Szabó Gy M , Thomas N , Torres G , Tronsgaard R , Udry S , Ulmer B , Van Grootel V , Vanderspek R , Venturini J , Walton N A , Winn J N , Wohler B 
Published: June 2023

ABSTRACT
We report the discovery of two warm sub-Neptunes transiting the bright (G = 9.5 mag) K-dwarf HD 15906 (TOI 461, TIC 4646810). This star was observed by the Transiting Exoplanet Survey Satellite (TESS) in sectors 4 and 31, revealing two small transiting planets. The inner planet, HD 15906 b, was detected with an unambiguous period but the outer planet, HD 15906 c, showed only two transits separated by ∼ 734 d, leading to 36 possible values of its period. We performed follow-up observations with the CHaracterising ExOPlanet Satellite (CHEOPS) to confirm the true period of HD 15906 c and improve the radius precision of the two planets. From TESS, CHEOPS, and additional ground-based photometry, we find that HD 15906 b has a radius of 2.24 ± 0.08 R⊕ and a period of 10.924709 ± 0.000032 d, whilst HD 15906 c has a radius of 2.93$^{+0.07}_{-0.06}$ R⊕ and a period of 21.583298$^{+0.000052}_{-0.000055}$ d. Assuming zero bond albedo and full day-night heat redistribution, the inner and outer planet have equilibrium temperatures of 668 ± 13 K and 532 ± 10 K, respectively. The HD 15906 system has become one of only six multiplanet systems with two warm (≲ 700 K) sub-Neptune sized planets transiting a bright star (G ≤ 10 mag). It is an excellent target for detailed characterization studies to constrain the composition of sub-Neptune planets and test theories of planet formation and evolution.
Halting migration in magnetospherically sculpted protoplanetary discs
Authors: Yu Tze Yeung Mathew , Hansen Brad , Hasegawa Yasuhiro 
Published: June 2023

ABSTRACT
We present a physically motivated model for the manner in which a stellar magnetic field sculpts the inner edge of a protoplanetary disc, and examines the consequence for the migration and stopping of sub-Neptune and super-Earth planets. This model incorporates a transition zone exterior to the inner truncation of the disc, where the surface density profile is modified by the diffusion of the stellar magnetic field into the disc. This modification results in a migration trap at the outer edge of the transition zone. We performed simulations of single-planet migration, considering a range of stellar magnetic field strengths and magnetic diffusion profiles. Our simulations show a tight relationship between the final locations of planets and the total magnetic budget available for the disc from their host star. We found that a stellar magnetic field between 67 and 180 G and a power-law index between 3 and 2.75 can reasonably reproduce the location at which the observed occurrence rate of close-in super-Earth and sub-Neptune populations changes slope.
An escaping outflow in a galaxy with an intermediate-mass black hole
Authors: Zheng Zhiyuan , Shi Yong , Bian Fuyan , Yu Xiaoling , Wang Junfeng , Chen Jianhang , Li Xin , Gu Qiusheng 
Published: June 2023

ABSTRACT
While in massive galaxies active galactic nucleus (AGN) feedback plays an important role, the role of AGN feedback is still under debate in dwarf galaxies. With well spatially resolved data obtained from the Multi-Unit Spectroscopic Explorer, we identify a spatially extended ($\rm \sim 3\,\, kpc$) and fast ($V_{80} \sim 471\,\, \rm km\,\,s^{-1}$) AGN-driven outflow in a dwarf galaxy: Sloan Digital Sky Survey J022849.51-090153.8 with $M_{*} \sim 10^{9.6}\,\,{\rm {\rm M}_{\odot }}$ that host an intermediate-mass black hole of $M_{\rm BH} \sim 10^5\,\,{\rm {\rm M}_{\odot }}$ and LAGN/LEdd ∼ 0.15. Through the measurement of the rotation curve, we estimate the escape velocity of the halo and the ratio of the outflow velocity to the halo escape velocity to be 1.09 ± 0.04, indicating that the outflow is capable of escaping not only the galaxy disc but the halo. The outflow size of our AGN is found to be larger than AGN in massive galaxies at the given AGN [O iii] luminosity, while the size of the photoionized narrow-line region is comparable. These results suggest the important role of AGN feedback through outflows in dwarf galaxies when their central intermediate-mass black holes accrete at high-Eddington ratios.
Rapid X-ray variability of the gamma-ray binary LS I +61°303
Authors: López-Miralles J , Motta Sara E , Migliari S , Jaron F 
Published: June 2023

ABSTRACT
The gamma-ray binary LS I +61°303 has been widely monitored at different wavelengths since its discovery more than 60 yr ago. However, the nature of the compact object and the peculiar behaviour of the system are still largely debated. Aimed at investigating the rapid X-ray variability of LS I +61°303, we have analysed all the archival Rossi X-ray Timing Explorer/Proportional Counter Array (RXTE/PCA) data of the source, taken between 1996 and 2011. The timing analysis yields a periodicity of P ∼ 26.6 ± 0.3 d, which is statistically compatible with several periodicities reported in the literature for LS I +61°303. Using this period, we performed a data phase-resolved analysis to produce a set of phase-bin-averaged energy spectra and power density spectra. These power density spectra are dominated by weak red noise below 0.1 Hz, and show no signal above this frequency. The amplitude of the red noise varies mildly with the phase, and shows a maximum that coincides with a dip of the X-ray flux and a softer photon index. Aside from low-frequency noise, this analysis does not provide any statistically significant periodic or quasi-periodic timing feature in the RXTE/PCA data of LS I +61°303.
On the stability of relativistic two-component AGN jets
Authors: Sinnis Charalampos , Millas Dimitrios , Vlahakis Nektarios 
Published: June 2023

ABSTRACT
A number of observations of astrophysical jets, at different scales, have shown that jets are often non-uniform outflows in their cross-section. Their structure is believed to play an important role in their overall stability. In this work, we combine analytical methods and numerical simulations to investigate the stability of non-uniform jets originating from active galactic nuclei. We adopt a standard ‘spine and sheath’ model, using a fast, light inner spine and a heavier, slower outer sheath. In the first part of this work, we conduct a linear stability analysis, finding the time-scales for the growth of the instabilities and the corresponding eigenfunctions. We focus on the nature of the physical processes that dominate and drive the destabilization of configurations. In the second part, we examine the evolution of the perturbed jets through relativistic 3D numerical simulations using the pluto code. Starting with the eigenfunctions found in the first part as initial conditions, we derive instability growth times and evolution which are in good agreement with the linear analysis.
Environments of red nuggets at z ∼ 0.7 from the VIPERS survey
Authors: Siudek M , Lisiecki K , Krywult J , Donevski D , Haines C P , Karska A , Małek K , Moutard T , Pollo A 
Published: June 2023

ABSTRACT
Red ultra-compact massive galaxies, called red nuggets were formed at high redshifts (z ∼ 2–3). Survivors of red nuggets, known as relics, observed at lower redshifts (z &lt; 2) are believed to remain almost unchanged since their formation. For the first time, we verify the environmental properties of red nuggets at intermediate redshift (0.5 &lt; z &lt; 0.9) using 42 red, massive (log(Mstar/M⊙) ≥ 10.9), and ultra compact (Re &lt; 1.5 kpc) from the VIMOS Public Extragalactic Redshift Survey (VIPERS). We found that the increasing fraction of red galaxies, when moving to denser environments, is driven by the red massive normal-size galaxies. Red nuggets, similarly to red intermediate-mass (10.4 ≲ log (Mstar/M⊙) &lt; 10.9) ultra-compact galaxies, are found in various types of environments, with consistent (within 1σ) fractions across all local densities. Analysis of red nugget stellar ages suggests that relics are preferably found in high-density regions while quiescent red nuggets are overabundant in low-density environments. We speculate that red nuggets have survived to lower redshifts via two channels: i) in low-density environments, where the fraction of red nuggets decreases as time passes due to (very) limited merger activity, ii) in high-density environments, where the number of red nuggets drops at higher redshift due to merger activity and is preserved at lower redshift as the high velocities of clusters prevent them from being cannibalized. Even more, the fraction of red nuggets in clusters may increase due to the addition of red massive normal-size galaxies deprived of their envelopes with cosmic time.
Probing quasar viewing angle with the variability structure function
Authors: Tang Ji-Jia , Wolf Christian , Tonry John , Lai Samuel , Yong Suk Yee , Steyn Zachary 
Published: June 2023

ABSTRACT
Given the anisotropic emission from quasar accretion discs, their viewing angle affects estimates of the quasar luminosity, black hole mass, and Eddington ratio. Discs appear overluminous when viewed pole-on and underluminous when viewed at high inclination. In radio-quiet quasars, the viewing angle is usually unknown, although spectroscopic indicators have been proposed. Here, we use a recently discovered universality in the variability structure function (SF) of quasar light curves (LCs), where all quasars show the same SF when clocks run in units of orbital time-scale. As an offset from the mean relation can be caused by incorrect orbital time-scales and thus incorrect luminosities, we correlate these offsets with suggested inclination indicators. We derive SFs from NASA/Asteroid Terrestrial-impact Last Alert System (ATLAS) LCs spanning ∼6 yr of observation, using a sample of 183 luminous quasars with measured H β lines as well as 753 quasars with C iv and Mg ii lines. Starting from the proposed orientation indicators, we expect quasars with narrower H β lines and with more blueshifted C iv lines to be viewed more pole-on and thus appear overluminous. In contrast, our SF analysis finds that presumed pole-on discs appear underluminous, consistently for both line indicators. We discuss possible explanations for the behaviour of quasars with highly blueshifted C iv lines irrespective of inclination angle, including dusty outflows that might render the accretion disc underluminous and flatter disc temperature profiles with longer orbital time-scales than in thin-disc models but reach no satisfying conclusion.
Flaring latitudes in ensembles of low-mass stars
Authors: Ilin Ekaterina , Angus Ruth , Luger Rodrigo , Morris Brett M , Jehn Florian U 
Published: June 2023

ABSTRACT
The distribution of small-scale magnetic fields in stellar photospheres is an important ingredient in our understanding of the magnetism of low-mass stars. Their spatial distribution connects the field generated in the stellar interior with the outer corona and the large scale field, and thereby affects the space weather of planets. Unfortunately, we lack techniques that can locate them on most low-mass stars. One strategy is to localize field concentrations using the flares that occur in their vicinity. We explore a new method that adapts the spot simulation software fleck to study the modulation of flaring times as a function of active latitude. We use empirical relations to construct flare light curves similar to those available from Kepler and the Transiting Exoplanet Survey Satellite (TESS), search them for flares, and use the waiting times between flares to determine the location of active latitudes. We find that the mean and standard deviations of the waiting time distribution provide a unique diagnostic of flaring latitudes as a function of the number of active regions. Latitudes are best recovered when stars have three or less active regions that flare repeatedly, and active latitude widths below 20 deg; when either increases, the information about the active latitude location is gradually lost. We demonstrate our technique on a sample of flaring G dwarfs observed with the Kepler satellite, and furthermore suggest that combining ensemble methods for spots and flares could overcome the limitations of each individual technique for the localization of surface magnetic fields.
How the dynamical properties of globular clusters impact their γ-ray and X-ray emission
Authors: de Menezes Raniere , Di Pierro Federico , Chiavassa Andrea 
Published: June 2023

ABSTRACT
The X-ray and γ-ray emission of globular clusters (GCs) is attributed to their large fraction of compact binary systems, especially those with millisecond pulsars (MSPs). We analyse a population of 124 Galactic GCs to investigate how their dynamical properties affect the formation and evolution of compact binary systems and how this can be translated into the clusters’ observed X-ray and γ-ray emission. We use mainly Chandra X-ray Observatory and Fermi Large Area Telescope observations to achieve our goals and start by detecting 39 GCs in γ rays, seven of which are not listed in previous Fermi-LAT catalogs. Additionally, we find that the total number of X-ray sources within a GC and its γ-ray luminosity are linearly correlated with the stellar encounter rate, indicating that compact binary systems are mainly formed via close stellar encounters. We also find an unexpected rise in the number of X-ray sources for GCs with low rates of stellar encounters, suggesting that there is a dynamical threshold where the formation of X-ray sources is dominated by stellar encounters. Furthermore, we use the Heggie-Hills law to find that subsequent stellar encounters in these compact binaries will, on average, make the binaries even harder, with basically no possibility of binary ionization. Finally, we find that all GCs are point-like sources in γ rays, indicating that the MSPs are concentrated in the clusters’ cores, likely due to dynamical friction.