bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of moderate endurance exercise on cardiac telomeres and cardiovascular remodeling in obese rats
Authors: Semeraro Maria Donatella , Beltrami Antonio Paolo , Kharrat Feras , Almer Gunter , Sedej Simon , Renner Wilfried , Gruber Hans-Jürgen , Curcio Francesco , Herrmann Markus 
Published: January 2023

IntroductionHypercaloric nutrition and physical inactivity cause obesity, a potential driver of myocardial apoptosis and senescence that may accelerate cardiac aging. Although physical activity reduces mortality, its impact on myocardial aging is insufficiently understood. Here we investigated the effects of a hypercaloric high-fat diet (HFD) and regular exercise training on cardiac cells telomeres and histomorphometric indices of cardiac aging.MethodsNinety-six 4-months old female Sprague-Dawley rats were fed for 10 months normal (ND) or a HFD diet. Half of the animals in each group performed 30 min treadmill-running sessions on 5 consecutive days per week. At study end, cardiomyocyte cross-sectional area (CSA), interstitial collagen content, vascular density, apoptotic and senescent cells, relative telomere length (RTL), and expression of telomerase-reverse transcriptase (Tert) as marker of telomere-related senescence and apoptosis were analyzed.ResultsCompared to ND, the HFD group developed obesity, higher CSA, lower capillary density and tended to have more apoptotic cardiomyocytes and interstitials cells. Myocardial RTL and the expression of Terf-1 and Terf-2 were comparable in sedentary HFD and ND animals. In the HFD group, regular moderate endurance exercise improved myocardial vascularization, but had no effect on CSA or apoptosis. Notably, the combination of exercise and HFD increased senescence when compared to sedentary ND or HFD, and reduced RTL when compared to exercise ND animals. Exercising HFD animals also showed a trend toward higher Tert expression compared to all other groups. In addition, exercise reduced Terf-1 expression regardless of diet.ConclusionHFD-induced obesity showed no effects on myocardial telomeres and induced only mild morphologic alterations. Summarized, long-term moderate endurance exercise partially reverses HFD-induced effects but may even trigger cardiac remodeling in the context of obesity.
An implantable loop recorder or smartphone based single-lead electrocardiogram to detect arrhythmia in adults with congenital heart disease?
Authors: Koole Maarten A. , Kauw Dirkjan , Kooiman Kirsten M. , de Groot Joris R. , Robbers-Visser Danielle , Tulevski Igor I. , Mulder Barbara J. , Bouma Berto J. , Schuuring Mark J. 
Published: January 2023

BackgroundThe European Society of Cardiology (ESC) guidelines for the management of adult congenital heart disease (ACHD) recommend screening in patients at risk for arrhythmic events. However, the optimal mode of detection is unknown.MethodsBaseline and follow-up data of symptomatic ACHD patients who received an implantable loop recorder (ILR) or who participated in a smartphone based single-lead electrocardiogram study were collected. The primary endpoint was time to first detected arrhythmia.ResultsIn total 116 ACHD patients (mean age 42 years, 44% male) were studied. The ILR group (n = 23) differed from the smartphone based single-lead electrocardiogram group (n = 93) in having a greater part of males and had more severe CHD and (near) syncope as qualifying diagnosis. In the smartphone based single-lead electrocardiogram group history of arrhythmia and palpitations were more frequent (all p &lt; 0.05). Monitoring was performed for 40 and 79 patient-years for the ILR- and smartphone based single-lead electrocardiogram group, respectively. Arrhythmias occurred in 33 patients with an equal median time for both groups to first arrhythmia of 3 months (HR of 0.7, p = 0.81). Furthermore, atrial fibrillation occurred most often (n = 16) and common therapy changes included medication changes (n = 7) and implantation of pacemaker or Implantable Cardioverter Defibrillator (ICD) (N = 4). Symptoms or mode of detection were not a determinant of the first event.ConclusionNon-invasive smartphone based single-lead electrocardiogram monitoring could be an acceptable alternative for ILR implantation in detecting arrhythmia in symptomatic ACHD patients in respect to diagnostic yield, safety and management decisions, especially in those without syncope.
Quantification of gas, ash, and sulphate aerosols in volcanic plumes from open path Fourier transform infrared (OP-FTIR) emission measurements at Stromboli volcano, Italy
Authors: Smekens Jean-François , Mather Tamsin A. , Burton Mike R. , La Spina Alessandro , Kabbabe Khristopher , Esse Benjamin , Varnam Matthew , Grainger Roy G. 
Published: January 2023

Field-portable Open Path Fourier Transform Infrared (OP-FTIR) spectrometers can be used to remotely measure the composition of volcanic plumes using absorption spectroscopy, providing invaluable data on total gas emissions. Quantifying the temporal evolution of gas compositions during an eruption helps develop models of volcanic processes and aids in eruption forecasting. Absorption measurements require a viewing geometry which aligns infrared source, plume, and instrument, which can be challenging. Here, we present a fast retrieval algorithm to estimate quantities of gas, ash and sulphate aerosols from thermal emission OP-FTIR measurements, and the results from two pilot campaigns on Stromboli volcano in Italy in 2019 and 2021. We validate the method by comparing time series of SO2 slant column densities retrieved using our method with those obtained from a conventional UV spectrometer, demonstrating that the two methods generally agree to within a factor of 2. The algorithm correctly identifies ash-rich plumes and gas bursts associated with explosions and quantifies the mass column densities and particle sizes of ash and sulphate aerosols (SA) in the plume. We compare the ash sizes retrieved using our method with the particle size distribution (PSD) of an ash sample collected during the period of measurements in 2019 by flying a Remotely Piloted Aircraft System into the path of a drifting ash plume and find that both modes of the bimodal PSD (a fine fraction with diameter around 5–10 μm and a coarse fraction around 65 μm) are identified within our datasets at different times. We measure a decrease in the retrieved ash particle size with distance downwind, consistent with settling of larger particles, which we also observed visually. We measure a decrease in the SO2/SA ratio as the plume travels downwind, coupled with an increase in measured SA particle size (range 2–6 μm), suggesting rapid hygroscopic particle growth and/or SO2 oxidation. We propose that infrared emission spectroscopy can be used to examine physical and chemical changes during plume transport and opens the possibility of remote night-time monitoring of volcanic plume emissions. These ground-based analyses may also aid the refinement of satellite-based aerosol retrievals.
Characteristics of the upper-level outflow and its impact on the rapid intensification of Typhoon Roke (2011)
Authors: Jin Ru , Li Yan , Chen Xianyan , Li Meiying 
Published: January 2023

In this study, we investigate the structural characteristics of the upper-level outflow and its impact on the rapid intensification (RI) of Typhoon Roke (2011), which experienced an evident outflow transformation from equatorward to poleward during its RI period. The simulations by the Weather Research and Forecasting Model suggest that the upper-level outflow extends from 100 hPa to 150 hPa, with an upper-level warm core at around 150 hPa. The upper-level outflow is enhanced ahead of the typhoon intensification, which is closely related to the outflow-environment interaction. Further analyses indicate that at the early stage of Roke (2011) before the RI, the strong equatorward outflow and the updraft south of the typhoon center are enhanced, favoring the onset of RI. During the RI period, the strong divergent flow near the entrance of the southwesterly jet in front of the upper-level trough, induces the poleward outflow. The eddy flux convergence of angular momentum inward propagated to the typhoon center from a 1000-km radius further enhances the poleward outflow and leads to the development of the vertical motion north of the typhoon center. Then Roke (2011) intensifies rapidly. Simultaneously, the shallow weak positive potential vorticity (PV) anomaly south of the southwesterly jet increases the inner-core PV, favoring the sustained intensification of Roke (2011). After Roke (2011) reaches its peak intensity, its intensity decreases due to the increase of vertical wind shear and the approaching of the southwesterly jet. It is indicated that the interaction between the upper-level outflow and the upper-tropospheric trough has significant influence on the RI of TC.
Influence of key parameters of ice accretion model under coexisting rain and fog weather
Authors: Zhou Yue , Wan Rong , Sun Jing , Gao Zhengxu , Yang Jialun 
Published: January 2023

Based on 30 complete wire icing processes lasted longer than 24 h observed from the Enshi, Jinsha, Dacaoping and Shennongding of Shennongjia in mountainous areas of Hubei province during the winter of 2008–2016, the macroscopic effects of rain–fog weather on the ice accretion process were analyzed. Furthermore, the distribution characteristics of key simulation parameters in supercooled fog (SF) and freezing rain (FR) were discussed according to the physical model of icing process. Finally, the evolution characteristics of the simulated ice thickness in rain–fog weather were proposed. Results showed that the duration of ice accretion in mountainous areas is the key factor affecting the maximum ice thickness; the freezing rain is most frequent during the glaze icing process, which leads to the substantial growth of ice thickness. The average growth rates of ice thickness with and without freezing rain are 1.26 mm h−1 and -0.11 mm h−1, respectively. Collision rate is the main parameter for inhibiting ice accretion of SF, with an average value of ∼ 0.1, while freezing rate is the main parameter for inhibiting ice accretion of FR, with an average value of ∼ 0.6. The ice accretion of SF shows the characteristics of periodic growth, while the ice accretion of FR shows the explosive growth of ice thickness, which makes the simulated values of icing closer to the observations. The ice formation efficiency of FR was more than twice that of SF, with a negative feedback mechanism to the ice accumulation of SF.
The intensification of coastal hypoxia off central Chile: Long term and high frequency variability
Authors: De La Maza Lucas , Farías Laura 
Published: January 2023

Hypoxia is a phenomenon where dissolved oxygen (DO) is reduced to levels that are low enough to strongly affect ecological and biogeochemical processes. This occurs within the continental shelf off central Chile (36°S), influenced by seasonal coastal upwelling (Spring-Summer). Monthly measurements of DO and other oceanographic variables in the water column (1997−2021) over the 92 m isobath along with high-resolution and near-surface observations (POSAR buoy), are analyzed to examine incidences of hypoxia and understand the physical and biogeochemical processes modulating DO vertical distribution and its temporal variability. On average, the percentage of the water column with DO levels below 89 (hypoxia) and 22 (severe hypoxia) μmol L−1 reaches 68% (i.e., hypoxic waters are found below 30 m) and 44% (below 50 m depth), respectively, but during the upwelling season, as much as 87% (below 12 m depth) and 81% (below 17 m depth) of the water column exhibits these levels. On the sub-seasonal scale during upwelling season six hypoxic events lasting at least 2 days occur at 10 m depth. There is a strong seasonal correlation between the volume of the seawater presenting hypoxia and upwelling favorable winds. Furthermore, there is a high DO interannual variability partially related to the El Niño Southern Oscillation (ENSO). Over 2 decades, it is estimated that DO concentration in surface and subsurface layers decreases (up to 21 μmol L−1 decade−1) as waters get colder (up to 0.29°C decade−1). Remarkably, the volume of hypoxic and severe hypoxic waters over the shelf has increased more than 2 times since 1997 and shows a significant positive correlation with the upwelling index. These preliminary findings indicate that the increase in local DO consumption is partially associated with upwelling intensification. Given the clear evidence of wind intensification in coastal upwelling ecosystems and thus the increase in hypoxic events, the coastal zone may be highly vulnerable to hypoxia, impacting biological resources and biogeochemical cycles.
The structure of a magnitude-frequency relation for debris flows conditioned by earthquake shock
Authors: Han Mei , Evans Stephen G. , He Kun , Sun Hao , Ma Zhigang 
Published: January 2023

Debris flow is a major secondary geological process associated with the 2008 M7.9 Wenchuan Earthquake area, causing the loss of around 200 lives as well as extensive property damage. Based on data developed over the past 21 years (1998–2018) of continuous monitoring of debris flow events in Sichuan, the temporal and spatial aspects of debris flows have been analyzed, including magnitude and frequency. The 21-year study period is divided into three time-intervals: 1998–2007 (pre-earthquake), 2008–2013 (short-term post-earthquake), and 2014–2018 (long-term post-earthquake). Distribution maps are plotted to compare debris flow distribution density in the three periods and to visualize debris flow development throughout Sichuan Province from 1998 to 2018. Many large-scale debris flows occur in groups immediately following the earthquake (2008–2013). After 2014, the magnitude and frequency of debris flows begin to decrease and gradually returned near to the pre-earthquake level as the damaged landscape recovered. The effect of rainfall is investigated by analyzing a 21-year record of precipitation; Following the earthquake the threshold rainfall values for debris flow triggering decrease only to recover to pre-earthquake levels as the landscape heals. Magnitude-frequency (M-F) relations for debris flows of the three periods were developed, and the distribution can be well fitted by a power-law function. Finally, the work done by debris flow was defined by multiplying the magnitude by frequency. At the regional scale, the work peaks in the three time periods have been determined and it is found that the peaks corresponded with the larger debris flow sizes. The concept of offset is introduced to describe the shift of the work peak in relation to the probability peak and is termed the Wolman-Miller offset. It is concluded that with a greater offset in the short-term post-earthquake period, more work has been done by larger events and that the greater proportion of the volume being mobilized by larger events occurring more frequently is a key process in the landscape returning to a pre-earthquake (equilibrium) state. The recovery of an earthquake-damaged landscape represents a transient period of high hazard that should be considered in any hazard assessment of earthquake-triggered landslides (in addition to co-seismic landslides).
Quaternary caldera-forming eruptions at the Sanzugawa caldera, NE Japan, revealed by zircon U-Pb geochronology
Authors: Ito Hisatoshi 
Published: January 2023

Recent application of zircon U-Pb geochronology has contributed to deciphering the evolution of caldera systems worldwide. However, in the Tohoku region, NE Japan, this is not the case, although it is well studied as a typical island arc subduction system. Here, U-Pb dating of zircon suggests that the Sanzugawa caldera, the largest caldera in Tohoku since late Miocene, initiated its caldera-forming volcanic activity at ∼7 Ma and culminated its activity in late Pliocene to Quaternary (3.0–1.5 Ma). This is contrary to a previous notion that the caldera developed in late Miocene to Pliocene (6–3 Ma) based on mainly whole-rock K-Ar dating results. This finding may also question a current hypothesis of relatively subdued volcanism at 3.5–1.5 Ma in NE Japan and thus shows the need to date other calderas in the Tohoku region with zircon U-Pb and/or Ar-Ar methods to better understand the magmatic history of this region.
Pore structure and fractal characteristics of Wufeng–Longmaxi formation shale in northern Yunnan–Guizhou, China
Authors: Wang Tao , Tian Fenghua , Deng Ze , Hu Haiyan 
Published: January 2023

In this study, the microscopic pore characteristics of shale in marine strata are evaluated. Based on field emission scanning electron microscopy (FE-SEM), low-temperature N2 adsorption (LT-N2GA), low-pressure CO2 adsorption (LP-CO2GA) and high-pressure methane adsorption (HPMA) experiments, the pore characteristics of 12 shales from the Wufeng–Longmaxi Formations in northern Yunnan and Guizhou are characterized qualitatively and quantitatively. Fractal Frenkel–Halsey–Hill (FHH) theory is used to analyse the fractal characteristics, and the adsorption pore characteristics of shale are discussed. The correlation between the fractal dimension and pore structure and adsorption performance is determined. The results show that the total organic carbon (TOC) contents of the 12 shales are in the middle–low level, ranging from 0.43% to 5.42%, and the shales are generally in the highly mature to overmaturity stage (vitrinite reflectance (Ro) values between 1.80% and 2.51%). The mineral composition is mainly quartz and clay minerals. The average clay mineral content is 40.98% (ranging from 24.7% to 63.3%), and the average quartz content is 29.03% (ranging from 16.8% to 39.6%), which are consistent with those of marine shale in the Sichuan Basin. FE-SEM and LT-N2GA isotherms reveal a complex shale pore structure and open pore style, mainly ink bottle-shaped and parallel plate-like pores. The total pore volumes (PVs) range from 0.012–0.052 cm3/g, and the specific surface area (SSA) values range from 18.112–38.466 m2/g. All shale samples have abundant micropores and mesopores, accounting for &gt;90% of the total SSA. The fractal dimensions, D1 and D2, were obtained from N2 adsorption data, with different adsorption characteristics at 0–0.5 and 0.5–1.0 relative pressures. The fractal dimensions increase with increasing BJH PV and BET SSA and decrease with decreasing average pore diameter (APD). The fractal dimensions are positively correlated with the TOC and clay mineral contents and negatively correlated with the quartz content. The fractal dimension can be used to evaluate the methane adsorption capacity; the larger the fractal dimension is, the larger the methane adsorption capacity is. Fractal analysis is helpful to better understand the pore structure and adsorption capacity of shale gas reservoirs.
The reference intervals for thyroid hormones: A four year investigation in Chinese population
Authors: Xie Tiancheng , Su Mingchuan , Feng Jie , Pan Xiaoying , Wang Chuan , Tang Tian 
Published: January 2023

IntroductionThe reference intervals (RIs) are of great importance for physicans to determine whether or not an individual is healthy. However, many clinical laboratories in China still adopted the default RI provided by the manufacturers; and these “uncalibrated” RIs might lead to the misdiagnosis of diseases. In the present study, we enroll reference people with the purpose of determining the RIs of serum triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH) in Chinese population, and explore the possible roles of age and sex on the levels of biomarkers.MethodsSerum samples from 66,609 individuals who met the inclusion criteria were analyzed using an Roche Cobas E 601 hormone analyzer. The dynamic trends of biomarker were visually assessed by their concentrations over age and sex. Specific partitions were determined by the method of Harris and Boyd. RIs, corresponding to the 2.5th and 97.5th percentiles, as well as the 0.5th, 25th, 50th, 75th and 99.5th percentiles were calculated for each reference partition using a non-parametric rank approach.ResultsThe serum level of T3, T4, FT4 or TSH showed a right-skewed distribution in both males and females while FT3 presented an approximate normal distribution. Females had a higher mode value of serum T3 or T4, but a lower mode value of serum TSH, FT3 or FT4. All five biomarkers did not need age partitioning according to the approach of harris and boyd, while T3 and FT3 need sex partitioning.ConclusionsThe present study not only determined the age- and sex-specific trends of the five thyroid hormones, but provided sex-stratified RIs for T3 and FT3, valuably contributing to the current literature and timely evaluation of thyroid health and disease.
Sequential algorithm to stratify liver fibrosis risk in overweight/obese metabolic dysfunction-associated fatty liver disease
Authors: Lee Chi-Ho , Lui David Tak-Wai , Li Raymond Hang-Wun , Yuen Michele Mae-Ann , Fong Carol Ho-Yi , Leung Ambrose Pak-Wah , Chu Justin Chiu-Man , Mak Loey Lung-Yi , Lam Tai-Hing , Woo Jean , Woo Yu-Cho , Xu Aimin , Tse Hung-Fat , Tan Kathryn Choon-Beng , Cheung Bernard Man-Yung , Yuen Man-Fung , Lam Karen Siu-Ling 
Published: January 2023

BackgroundNon-diabetic overweight/obese metabolic dysfunction-associated fatty liver disease (MAFLD) represents the largest subgroup with heterogeneous liver fibrosis risk. Metabolic dysfunction promotes liver fibrosis. Here, we investigated whether incorporating additional metabolic risk factors into clinical evaluation improved liver fibrosis risk stratification among individuals with non-diabetic overweight/obese MAFLD.Materials and methodsComprehensive metabolic evaluation including 75-gram oral glucose tolerance test was performed in over 1000 participants from the New Hong Kong Cardiovascular Risk Factor Prevalence Study (HK-NCRISPS), a contemporary population-based study of HK Chinese. Hepatic steatosis and fibrosis were evaluated based on controlled attenuation parameter and liver stiffness (LS) measured using vibration-controlled transient elastography, respectively. Clinically significant liver fibrosis was defined as LS ≥8.0 kPa. Our findings were validated in an independent pooled cohort comprising individuals with obesity and/or polycystic ovarian syndrome.ResultsOf the 1020 recruited community-dwelling individuals, 312 (30.6%) had non-diabetic overweight/obese MAFLD. Among them, 6.4% had LS ≥8.0 kPa. In multivariable stepwise logistic regression analysis, abnormal serum aspartate aminotransferase (AST) (OR 7.95, p&lt;0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) ≥2.5 (OR 5.01, p=0.008) were independently associated with LS ≥8.0 kPa, in a model also consisting of other metabolic risk factors including central adiposity, hypertension, dyslipidaemia and prediabetes. A sequential screening algorithm using abnormal AST, followed by elevated HOMA-IR, was developed to identify individuals with LS ≥8.0 kPa, and externally validated with satisfactory sensitivity (&gt;80%) and negative predictive value (&gt;90%).ConclusionA sequential algorithm incorporating AST and HOMA-IR levels improves fibrosis risk stratification among non-diabetic overweight/obese MAFLD individuals.