bluuebunny/crossref_metadata_2025_split huggingface dataset:
Listing quality: Chinese journal lists in incoherent valuation regimes
Authors: Wang Jing , Halffman Willem , Horbach Serge P J M 
Published: September 2023

Abstract
Lists of endorsed and discouraged scholarly publications recently emerged as an important transition in Chinese journal evaluation. Among the targeted users of these lists are researchers, who are to avoid publishing in discouraged journals and focus efforts on endorsed journals. However, it is unclear how these lists affect researchers’ valuations when choosing publication outlets. This explorative study investigates the reception of such journal lists in Chinese scientists’ research practices. Our findings suggest that three logics interact in respondents’ journal valuations: institutional evaluation regimes, differing epistemic cultures, and the influence of the commercial publishing industry. The reactive effects of both endorsed and discouraged journal lists appear to differ with the ranking status of universities, the seniority of scholars, and research fields. Apart from the new institutional evaluation regimes in this interplay, there appear to be more predominant factors than journal lists that inform publishing choices: quantitative indicators, publishers’ branding, epistemic cultures, and editorial procedures and publishing models.
Rethinking moral hazard: government protection and bank risk-taking
Authors: Pernell Kim , Jung Jiwook 
Published: September 2023

Abstract
Why do firms take excessive risks that result in failure? Moral hazard theorists argue that the answer lies in the risk-boosting effects of the government safety net, which insulates firms from market discipline. We revisit this conventional wisdom by examining how exposure to government protection has contributed to recent trends in bank risk-taking in the USA. Drawing from insights from economic sociology, we highlight an additional way that exposure to government protection can shape organizational behavior: by reducing resource-based profitability pressures that can spur risky behavior. Using panel data analysis of risky US bank behavior between 1994 and 2015, we find that bank exposure to government protection was more often associated with less risk-taking than more of it. This pattern contradicts the predictions of moral hazard theory but aligns with the predictions of our own institutional-resource theory. We discuss implications for economic sociology and financial economics.
A nomogram proposal for early prediction of intensive care unit admission in patients with acute antipsychotic poisoning
Authors: El-Gharbawy Doaa M , Kabbash Ibrahim Ali , Ghonem Mona M 
Published: September 2023

Abstract

Background
Early identification of antipsychotic poisoned patients who may have a potential risk for intensive care unit (ICU) admission is crucial especially when resources are limited. Nomograms were previously used as a practical tool to predict prognosis and planning the treatment of some diseases including some poisoning conditions. However, they were not previously investigated in antipsychotic poisoning.

Aim
The current study aimed to construct a nomogram to predict the need for ICU admission in acute antipsychotic poisoning. Patients and methods: This 2-year study included 140 patients acutely intoxicated with antipsychotics and admitted at Tanta University Poison Control Centre throughout July 2019 to June 2021. Personal and toxicological data, findings of clinical examination and electrocardiography, as well as, results of laboratory investigations at time of admission were recorded. According to the outcome, patients were divided into ICU-admitted and ICU-not admitted groups.

Results
The results of this study provided a proposed nomogram that included five significant independent predictors for ICU admission in acute antipsychotic intoxications; the presence of seizures (OR: 31132.26[108.97-Inf]), corrected QT interval (OR: 1.04[1.01–1.09]), mean arterial blood pressure (OR: 0.83[0.70–0.92]), oxygen saturation (OR: 0.62[0.40 to 0.83)], and Glasgow Coma Scale (OR: 0.25 [0.06–0.56]).

Conclusion
It could be concluded that the developed nomogram is a promising tool for easy and rapid decision making to predict the need for ICU admission in acute antipsychotic poisoning.
Effects of Rosmarinus officinalis L. (Laminaceae) essential oil on adult and larvae of Drosophila melanogaster
Authors: Pedroso Aline Lucca , Schonwald Miryane Knapp , Dalla Corte Cristiane Lenz , Soares Felix Alexandre Antunes , Sperança Adriane , Godoi Benhur , de Carvalho Nélson Rodrigues 
Published: September 2023

Abstract
Rosmarinus officinalis (Lamiaceae family), also known as “alecrim,” is a perennial herb, typical of the Mediterranean region and widely distributed in Brazilian territory. Despite having demonstrated several properties of human interest, insecticide/larvicidal effect of essential oil from R. officinalis on insects remains unclear. In this study, we tested the effects of R. officinalis essential oil on biomarkers of oxidative damage in Drosophila melanogaster. Exposure to R. officinalis essential oil increased adult mortality and decreased geotaxis behavior in adult fruit flies. In addition, essential oil increased of larval mortality and impaired the developmental success in D. melanogaster. R. officinalis essential oil showed a significant repellent effect, with duration time of about 6 h. To understand the mechanism underlying the toxicity of essential oil both pro-oxidant effects and biomarkers of oxidative damage were evaluated in exposed flies. Exposure to essential oil caused a significant redox imbalance with impairment of both enzymatic and non-enzymatic antioxidant system and increased the lipid peroxidation levels. These results suggest that R. officinalis essential oil can be used as a bioinsecticide and/or larvicide as well as an alternative insect repellent.
Melatonin treatment prevents carbon-tetrachloride induced rat brain injury
Authors: Stojanović Nikola M , Maslovarić Aleksandra , Mihajlović Ivana , Marković Aleksandar , Randjelović Pavle J , Sokolović Dušan 
Published: September 2023

AbstractIntroductionHerein the neuroprotective properties of melatonin, a highly effective antioxidant, administered in a single dose 50 mg/kg intraperitoneally, were investigated in the brain tissue of Wistar rats acutely exposed to the toxin carbon-tetrachloride (1 mL/kg, intraperitoneally).MethodsTo assess the degree of whole encephalic mass damage, biochemical parameters related to lipid and protein oxidation, antioxidant enzymes (catalase and superoxide dismutase), glutathione and inducible nitric oxide/arginase pathways were determined.ResultsThe results showed that carbon-tetrachloride impaired the function of antioxidant enzymes (reduced catalase and superoxide dismutase activities) and reduced glutathione-metabolizing enzymes (reduced glutathione, glutathione S-transferase and peroxidase activity). Furthermore, carbon-tetrachloride increased lipid peroxidation and protein oxidative damage in the brain tissue, as well as myeloperoxidase and inducible nitric oxide synthase content/activities.ConclusionsThe application of a single dose of melatonin post intoxication has been able to reverse the disturbance in the function of antioxidant enzymes and alleviate the tissue damage caused by oxidative stress, indicating that melatonin could be a potential therapeutic agent in oxidative-damage related neurodegenerative disorders.
Freeze dehydration vs supercooling in tree stems: physical and physiological modelling
Authors: Bozonnet Cyril , Saudreau Marc , Badel Eric , Améglio Thierry , Charrier Guillaume 
Published: September 2023

Abstract
Frost resistance is the major factor affecting the distribution of plant species at high latitude and elevation. The main effects of freeze–thaw cycles are damage to living cells and formation of gas embolism in tree xylem vessels. Lethal intracellular freezing can be prevented in living cells by two mechanisms, such as dehydration and deep supercooling. We developed a multiphysics numerical model coupling water flow, heat transfer and phase change, considering different cell types in plant tissues, to study the dynamics and extent of cell dehydration, xylem pressure changes and stem diameter changes in response to freezing and thawing. Results were validated using experimental data for stem diameter changes of walnut trees (Juglans regia). The effect of cell mechanical properties was found to be negligible as long as the intracellular tension developed during dehydration was sufficiently low compared with the ice-induced cryostatic suction. The model was finally used to explore the coupled effects of relevant physiological parameters (initial water and sugar content) and environmental conditions (air temperature variations) on the dynamics and extent of dehydration. It revealed configurations where cell dehydration could be sufficient to protect cells from intracellular freezing, and situations where supercooling was necessary. This model, freely available with this paper, could easily be extended to explore different anatomical structures, different species and more complex physical processes.
Modeling the response of Norway spruce tree-ring carbon and oxygen isotopes to selection harvest on a drained peatland forest
Authors: Tikkasalo Olli-Pekka , Leppä Kersti , Launiainen Samuli , Peltoniemi Mikko , Mäkipää Raisa , Rinne-Garmston Katja T , Sahlstedt Elina , Young Giles H F , Bokareva Aleksandra , Lohila Annalea , Korkiakoski Mika , Schiestl-Aalto Pauliina , Lehtonen Aleksi 
Published: September 2023

Abstract
Continuous cover forestry (CCF) has gained interest as an alternative to even-aged management particularly on drained peatland forests. However, relatively little is known about the physiological response of suppressed trees when larger trees are removed as a part of CCF practices. Consequently, studies concentrating on process-level modeling of the response of trees to selection harvesting are also rare. Here, we compared, modeled and measured harvest response of previously suppressed Norway spruce (Picea abies) trees to a selection harvest. We quantified the harvest response by collecting Norway spruce tree-ring samples in a drained peatland forest site and measuring the change in stable carbon and oxygen isotopic ratios of wood formed during 2010–20, including five post-harvest years. The measured isotopic ratios were compared with ecosystem-level process model predictions for ${\kern0em }^{13}$C discrimination and ${\kern0em }^{18}$O leaf water enrichment. We found that the model predicted similar but lower harvest response than the measurements. Furthermore, accounting for mesophyll conductance was important for capturing the variation in ${\kern0em }^{13}$C discrimination. In addition, we performed sensitivity analysis on the model, which suggests that the modeled ${\kern0em }^{13}$C discrimination is sensitive to parameters related to CO2 transport through stomata to the mesophyll.
TGF‐β1 reduces the differentiation of porcine IgA‐producing plasma cells by inducing IgM+ B cells apoptosis via Bax/Bcl2‐Caspase3 pathway
Authors: Wang Caiying , Yang Shanshan , Huang Xin , Lu Yabin , Zhang Yue , Li Maolin , Zhao Jing , Li Shuxian , Savelkoul Huub , Jansen Christine , Liu Guangliang 
Published: September 2023

AbstractTransforming growth factor β1 (TGF‐β1) performs a critical role in maintaining homeostasis of intestinal mucosa regulation and controls the survival, proliferation, and differentiation of many immune cells. In this study, we discovered that the infection of porcine epidemic diarrhea virus (PEDV), a coronavirus, upregulated TGF‐β1 expression via activating Tregs. Besides, recombinant porcine TGF‐β1 decreased the percentage of CD21+ B cells within the lymphocyte population in vitro. We further found that TGF‐β1 reduced the IgA‐secreting B cell numbers and also inhibited plasma cell differentiation. Additional investigations revealed that TGF‐β1 induced the apoptosis of IgM+ B cells in both peyer's patches (PPs) and peripheral blood (PB) through the activation of the Bax/Bcl2‐Caspase3 pathway. Conversely, the application of the TGF‐β1 signaling inhibitor SB431542 significantly antagonized the TGF‐β1‐induced reduction of IgA secretion and B cell apoptosis and restored plasma cell differentiation. Collectively, TGF‐β1 plays an important role in regulating the survival and differentiation of porcine IgA‐secreting B cells through the classical mitochondrial apoptosis pathway. These findings will facilitate future mucosal vaccine designs that target the regulation of TGF‐β1 for the control of enteric pathogens in the pig industry.
Identifying risk factors for osteonecrosis after talar fracture
Authors: Alley Maxwell C. , Vallier Heather A. , Tornetta Paul ,   and the Orthopaedic Trauma Research Consortium
Published: September 2023

Abstract

Objective:
To identify patient, injury, and treatment factors associated with development of avascular necrosis (AVN)
following talar fractures, with particular interest in modifiable factors.

Design:
Retrospective chart review.

Setting:
21 US trauma centers and 1 UK trauma center.

Patients:
2,220 patients with talar neck and/or body fractures.

Intervention:
Open reduction internal fixation of talar neck and body fractures.

Main Outcome Measurements:
Development of AVN. Infection, nonunion, and arthritis were secondary outcomes.

Results:
796 patients (408 M; 388 F; age 18-81, avg 38.6) with 796 (532R; 264L) fractures were included and were classified as Hawkins 1(51), IIA(71), IIB(113), III(158), IV(40), neck plus body (177), body (188). 336/798 developed AVN (42%), more commonly following any neck fracture (47.0%) vs isolated body fracture (26.1%, p<0.001). More severe Hawkins’ classification, combined neck and body fractures, body mass index (BMI), tobacco smoking, right-sided fractures, open fracture, dual anteromedial and anterolateral surgical approaches, and associated medial malleolus fracture were associated with AVN. After multivariate regression, fracture type, tobacco smoking, open fractures, dual approaches, age, and BMI remained significant.Excluding late cases (>7 days), time to joint reduction for Hawkins type IIB-IV neck injuries was no different for those who developed AVN or not. AVN rates for reduction of dislocations within 6 hours of injury vs >6 hours were 48.8% and 57.5%, respectively. Complications included 60 (7.5%) infections and 70 (8.8%) nonunions.

Conclusion:
42% of all patients developed AVN, with talar neck fractures, more displaced fractures and open injuries having higher rates. Injury-related factors are most prognostic of AVN risk. Surgical technique to emphasize anatomical reduction, without iatrogenic damage to remaining blood supply is essential.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Intravenous Ketorolac Substantially Reduces Opioid Use and Length of Stay After Lumbar Fusion
Authors: Iyer Sravisht , Steinhaus Michael E. , Kazarian Gregory S. , Zgonis Evangelia M. , Cunningham Matthew E. , Farmer James C. , Kim Han Jo , Lebl Darren R. , Huang Russel C. , Lafage Virginie , Schwab Frank J. , Qureshi Sheeraz , Girardi Federico P. , Rawlins Bernard A. , Beckman James D. , Carrino John A. , Chazen J. Levi , Varghese Jeffrey J. , Muzammil Hamna , Lafage Renaud , Sandhu Harvinder S. 
Published: September 2023

Study Design.
A randomized, double-blinded, placebo-controlled trial.

Objective.
To examine the effect of intravenous ketorolac (IV-K) on hospital opioid use compared with IV-placebo (IV-P) and IV acetaminophen (IV-A).

Summary of Background Data.
Controlling postoperative pain while minimizing opioid use after lumbar spinal fusion is an important area of study.

Patients and Methods.
Patients aged 18 to 75 years undergoing 1 to 2 level lumbar fusions between April 2016 and December 2019 were included. Patients with chronic opioid use, smokers, and those on systemic glucocorticoids or contraindications to study medications were excluded. A block randomization scheme was used, and study personnel, hospital staff, and subjects were blinded to the assignment. Patients were randomized postoperatively. The IV-K group received 15 mg (age > 65) or 30 mg (age < 65) every six hours (q6h) for 48 hours, IV-A received 1000 mg q6h, and IV-P received normal saline q6h for 48 hours. Demographic and surgical details, opioid use in morphine milliequivalents, opioid-related adverse events, and length of stay (LOS) were recorded. The primary outcome was in-hospital opioid use up to 72 hours.

Results.
A total of 171 patients were included (58 IV-K, 55 IV-A, and 58 IV-P) in the intent-to-treat (ITT) analysis, with a mean age of 57.1 years. The IV-K group had lower opioid use at 72 hours (173 ± 157 mg) versus IV-A (255 ± 179 mg) and IV-P (299 ± 179 mg; P = 0.000). In terms of opiate use, IV-K was superior to IV-A (P = 0.025) and IV-P (P = 0.000) on ITT analysis, although on per-protocol analysis, the difference with IV-A did not reach significance (P = 0.063). When compared with IV-P, IV-K patients reported significantly lower worst (P = 0.004), best (P = 0.001), average (P = 0.001), and current pain (P = 0.002) on postoperative day 1, and significantly shorter LOS (P = 0.009) on ITT analysis. There were no differences in opioid-related adverse events, drain output, clinical outcomes, transfusion rates, or fusion rates.

Conclusions.
By reducing opioid use, improving pain control on postoperative day 1, and decreasing LOS without increases in complications or pseudarthrosis, IV-K may be an important component of “enhanced recovery after surgery” protocols.
Usefulness of Ultrasound in Verrucous Venous Malformation: a Series of 103 Cases
Authors: Gong Xia , Chang Shih-Jen , Xiong Ping , Lin Xiaoxi , Wang Lizhen 
Published: September 2023

BACKGROUND
Verrucous venous malformation (VVM), previously called “verrucous hemangioma,” is a rare type of vascular malformation.

OBJECTIVE
Little is known about the ultrasonographic characteristics of VVM. The present study aimed to show the conventional US and elastographic features of a VVM.

MATERIALS AND METHODS
The US findings in 103 patients with VVMs were retrospectively evaluated.

RESULTS
On gray-scale ultrasound images, 98 (95.1%) lesions showed subcutaneous fat infiltration from skin across muscle to deep fascia. The other 5 (4.9%) sat in the subcutaneous layer with no skin involvement. Most (96.1%) lesions were hyperechoic. Furthermore, 71.8% of lesions were heterogeneous, 68.9% of which were with ill-defined margins. Calcifications and visible vessels were present in 5.7% and 10.7% of the VVM cases, respectively. By color Doppler ultrasound, all lesions were found with low vascular density and 4.9% showed enhanced blood flow after compression. Venous spectrum was observed in 67.0% of lesions. The elasticity score was 2.66 ± 0.48.

CONCLUSION
Diagnosis of a VVM is challenging in the clinic. However, we found that most VVM lesions present distinctive ultrasound imaging characteristics. These ultrasound findings may well contribute to the accuracy of VVM diagnosis, especially in those with the absence of epidermal changes and the lack of dermal involvement.
Low-density lipoprotein subclasses over the menopausal transition and risk of coronary calcification and carotid atherosclerosis: the SWAN Heart and HDL ancillary studies
Authors: El Khoudary Samar R. , Chen Xirun , Wang Ziyuan , Brooks Maria M. , Orchard Trevor , Crawford Sybil , Janssen Imke , Everson-Rose Susan A. , McConnell Daniel , Matthews Karen 
Published: September 2023

Abstract

Objective
Perimenopausal women experience a steep increase in low-density lipoprotein cholesterol (LDL-C) that is related to a higher risk of carotid plaque later in life. Low-density lipoprotein subclasses have been linked to cardiovascular diseases beyond LDL-C, promising a better risk stratification. We aim to characterize changes in LDL subclasses and assess their associations with presence of coronary artery calcium (CAC score ≥10) and carotid intima-media thickness (cIMT) over the menopausal transition (MT) and by menopause stage.

Methods
Nuclear magnetic resonance spectroscopy LDL subclasses were measured for a maximum of five time points. Coronary artery calcification and cIMT were measured for a maximum of two time points. LOESS (locally weighted regression with scatter smoothing) plots, linear mixed-effects models, and generalized estimating equations were used for analyses.

Results
The study included 471 women (baseline: age, 50.2 ± 2.7 years; 79.0% premenopausal/early perimenopausal), of whom 221 had data on CAC or cIMT. Low-density lipoprotein subclasses increased over the MT, whereas intermediate density-lipoprotein particles declined. In adjusted models, higher total LDL particles (LDL-P) and apolipoprotein B were associated with greater CAC prevalence and greater cIMT. Although none of the associations were modified by menopause stage, higher LDL-C, apolipoprotein B, and total LDL-P were associated with greater cIMT during the perimenopause or postmenopause stages, whereas higher LDL-C and small LDL-P were associated with greater CAC prevalence, mainly during perimenopause.

Conclusions
During the MT, women experience significant increases in LDL subclasses found to be related to greater cIMT levels and CAC prevalence. Whether these changes could better predict future risk of hard cardiovascular disease events beyond LDL-C remains a research question to address.
Correlation between Indocyanine Green Fluorescence Angiography and Laser Speckle Contrast Imaging in a Flap Model
Authors: Zötterman Johan , Tesselaar Erik , Elawa Sherif , Farnebo Simon 
Published: September 2023

Background:
Indocyanine green fluorescence angiography (ICG-FA) is used to assess tissue intraoperatively in reconstructive surgery. This requires an intra-venous dye injection for each assessment. This is not necessary in laser speckle contrast imaging (LSCI); therefore, this method may be better suited for tissue evaluation. To determine this, we compared the two methods in a porcine flap model.

Methods:
One random and one pedicled flap were raised on each buttock of six animals. They were assessed with LSCI at baseline, when raised (T0), at 30 minutes (T30) and with ICG-FA at T0 and T30. Regions of interest (ROI) were chosen along the flap axis. Perfusion, measured as perfusion units (PU) in the LSCI assessment and pixel-intensity for the ICG-FA video uptake, was calculated in the ROI. Correlation was calculated between PU and pixel-intensity measured as time to peak (TTP) and area under curve for 60 seconds (AUC60).

Results:
Correlation between LSCI and AUC60 for the ICG-FA in corresponding ROI could be seen in all flaps at all time points. The correlation was higher for T0 (r=0.7 for random flap and r=0.6 for pedicled flap) than for T30 (r=0.57 for random flap and r=0.59 for pedicled flap). Even higher correlation could be seen PU and TTP (T0: random flap r=-0.8 and pedicled flap r=0.76. T30: random flap r=-0.8 and pedicled flap r=0.71)

Conclusion:
There is a correlation between PU from LSCI and TTP and AUC60 for ICG-FA, indicating that LSCI could be considered for intraoperative tissue assessment.