bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, predictors, and impact of acute post-operative pain after cranial neurosurgery: A prospective cohort study
Authors: Sriganesh Kamath , Kramer Boris W. , Wadhwa Archisha , Akash V. S. , Bharadwaj Suparna , Rao G. S. Umamaheswara , Steinbusch Harry W. M. , Konar Subhas K. , Gopalakrishna Kadarapura Nanjundaiah , Sathyaprabha T. N. 
Published: July 2023

Objectives:
Pain is common after craniotomy. Its incidence and predictors in developing nations are not adequately studied. We aimed to assess the incidence, predictors, and impact of acute post-operative pain after intracranial neurosurgeries.

Materials and Methods:
This prospective observational study was conducted in adult patients undergoing intracranial neurosurgeries. After patient consent, ethics committee approval, and study registration, we assessed the incidence of post-operative pain using numerical rating scale (NRS) score. Predictors and impact of pain on patient outcomes were also evaluated.

Results:
A total of 497 patients were recruited during 10-month study period. Significant (4–10 NRS score) post-operative pain at any time-point during the first 3 days after intracranial neurosurgery was reported by 65.5% (307/469) of patients. Incidence of significant pain during the 1st post-operative h, on the 1st, 2nd, and 3rd post-operative days was 20% (78/391), 50% (209/418), 38% (152/401), and 24% (86/360), respectively. Higher pre-operative NRS score and pain during the 1st h post-operatively, predicted the occurrence of pain during the first 3 days after surgery, P = 0.003 and P < 0.001, respectively. Pain was significantly associated with poor sleep quality on the first 2 post-operative nights (P < 0.001). Patient satisfaction score was higher in patients with post-operative pain, P = 0.002.

Conclusion:
Every two in three patients undergoing elective intracranial neurosurgery report significant pain at some point during the first 3 postoperative days. Pre-operative pain and pain during 1st post-operative h predict the occurrence of significant post-operative pain.
Assessment of onset-to-door time in acute ischemic stroke and factors associated with delay at a tertiary care center in South India
Authors: Anees Ashika , Panicker Praveen , Iype Thomas , Sreelekha K. R. 
Published: July 2023

Objectives:
Intravenous thrombolysis is an effective treatment of acute ischemic stroke but has a narrow therapeutic time window of 3–4.5 h. Pre-hospital delay is a major barrier to patients becoming eligible for thrombolysis. This single-center study assessed the factors causing longer onset-to-door (OTD) time to identify measures that will help decrease the delay.

Materials and Methods:
Patients with acute ischemic stroke presenting to the emergency department from August to October 2022 were included in the study. The data were collected using a structured questionnaire and was completed by interviewing the patient or the caregivers. Patients were classified as early and late arrivers with the cutoff being 3.5 h. We then analyzed the relationship between early arrival and demographic factors, clinical factors, patient response factors, and logistic factors.

Results:
Our study consisted of 153 patients. The average OTD time was 674.33 ± 812.713 min (median: 300; interquartile range: 151–885). The pre-hospital delay was present in 66% of patients. 16.9% of patients came beyond 24 h. In the multivariate analysis, the odds of early arrival were higher among patients who perceived their symptoms as serious (odds ratio [OR]: 18.801; confidence interval [CI]: 3.728–94.803) and lower among patients who experienced a delay in reaching due to traffic (OR: 0.085; CI: 0.008–0.873). Lack of knowledge about stroke centers among both patients and health professionals also contributed to longer OTD times. Out of 52 early arrivers, 24 received thrombolytic therapy after excluding wake-up strokes and contraindications.

Conclusion:
Pre-hospital delay continues to stand in the way of patients receiving thrombolysis. Comprehensive stroke education, increasing awareness regarding stroke centers, and promoting ambulance services are some of the interventions which could help tackle the issue.
Resective epilepsy surgery in a limited-resource settings: A cohort from a multi-disciplinary epilepsy team in a developing country
Authors: Hamdi Hussein , Kishk Nirmeen , Shamloul Reham , Moawad Mona K. , Baghdadi Micheal , Rizkallah Mina , Nawito Amani , Mohammad Mohammad Edrees , Nazmi Hatem , Nasr Yasser Mohamed , Waly Salwa Hassan , Elshahat Mo’men , Magdy Rehab , Othman Alshimaa S. , Nafea Hesham , Fouad Amro M , Elantably Ismail , Rizk Haytham , Elsayyad Enas , Morsy Ahmed A. 
Published: July 2023

Background:
Multidisciplinary pre-surgical evaluation is vital for epilepsy surgery decision and outcomes. Resective epilepsy surgery with assisted monitoring is currently a standard treatment for focal drug resistant epilepsy (DRE). In resource-limited countries, lack of epilepsy surgery center is a huge challenge. We presented and illustrated how to create a multidisciplinary protocol with resource-limited settings in a developing country and epilepsy surgery outcome using brain mapping and monitoring techniques for ensuring satisfactory resection.

Methods:
We created multicentric incomplete but complementary units covering all epilepsy-related sub-specialties and covering a wide geographical area in our country. Then, we conducted a prospective and multicentric study with low resource settings on patients with focal DRE, who underwent resective epilepsy surgery and were followed up for at least 12 months and were evaluated for postoperative seizure outcome and complications if present. Preoperative comprehensive clinical, neurophysiological, neuropsychological, and radiological evaluations were performed by multidisciplinary epilepsy team. Intraoperative brain mapping including awake craniotomy and direct stimulation techniques, neurophysiological monitoring, and electrocorticography was carried out during surgical resection.

Results:
The study included 47 patients (18 females and 29 males) with mean age 20.4 ± 10.02 years. Twenty-two (46.8%) patients were temporal epilepsy while 25 (53.2%) were extra-temporal epilepsy. The epilepsy surgery outcome at the last follow up was Engel Class I (seizure free) in 35 (74.5%), Class II (almost seizure free) in 8 (17%), Class III (worthwhile improvement) in 3 (6.4%), and Class IV (no worthwhile improvement) in 1 patient (2.1%).

Conclusion:
With low resource settings and lack of single fully equipped epilepsy center, favorable outcomes after resective surgery in patients with focal DRE could be achieved using careful presurgical multidisciplinary selection, especially with using intraoperative brain mapping and electrocorticography techniques.
Visual-evoked potential predicts the efficacy of the optical canal decompression for traumatic optic nerve neuropathy showing blindness: A case report
Authors: Otsu Yusuke , Komaki Satoru , Takeshige Nobuyuki , Sakata Kiyohiko , Morioka Motohiro 
Published: July 2023

Background:
The indication for surgical optic canal decompression (OCD) for traumatic optic neuropathy (TON) remains controversial because there is no reliable predictor of a good outcome. We report the case of a blind patient with TON whose remaining visual-evoked potential (VEP) suggested recovery potential of the injured optic nerve after OCD.

Case Description:
A 48-year-old man had fallen from a height of 7 m, striking his head. He immediately complained of right-eye blindness. He had no light perception and the direct light reflex disappeared from the right pupil, although there was no fracture or traumatic lesion on computed tomography and magnetic resonance imaging. Because the amplitude of the VEP with the right eye stimulation remained unchanged, we performed the right OCD. During surgical OCD, the amplitude and latency of VEP began to improve. Finally, the visual field improved in almost all directions, and eyesight improved to 0.2.

Conclusion:
The retained VEP activity in TON may suggest the recovery potential of the injured optic nerve, even in cases of blindness. It is possible that VEP is an indicator of aggressive treatment for TON such as OCD.
Characteristics, comorbidities, and complications in multiple sclerosis (MS) and non-MS patients undergoing lumbar fusion for deformity
Authors: Sulovari Aron , Kurucan Etka , Bernstein David Nathan , Mesfin Addisu 
Published: July 2023

Background:
We compared the characteristics, comorbidities, and complications in spinal deformity patients with and without multiple sclerosis (MS) undergoing primary lumbar spine fusion.

Methods:
We used the Nationwide Inpatient Sample (NIS) from 2003 to 2014, International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis and procedure codes to create experimental MS (842 patients) and non-MS control (165,726 patients) cohorts undergoing primary lumbar spine fusion. Characteristics, comorbidities, and complications in spinal deformity patients with and without MS were evaluated using univariate and bivariate analysis.

Results:
MS spinal deformity patients undergoing primary lumbar spine fusion were younger, more likely to be female and more likely to undergo surgery at urban teaching hospitals. They also exhibited higher rates of depression and lower rates of diabetes without chronic complications, hypertension, and renal failure. However, no significant differences were found in mortality or total perioperative complication rates between MS and nonMS patients.

Conclusion:
We found that MS versus non-MS patients undergoing primary lumbar fusion for spinal deformity were younger, more likely to be female and had higher rates of depression but lower rates of diabetes, hypertension, and renal failure. Notably, both groups experienced comparable mortality and perioperative complication rates.
LOBACHEVSKY GEOMETRY – THE FIRST NON-CLASSICAL SCIENTIFIC THEORY
Authors: Коськов С.Н. 
Published: July 2023

Обычно появление неклассической науки относят к началу XX в. Прежде всего имеют в виду теорию относительности, квантовую механику, излучение энергии, генетику, что совершенно справедливо. Но автор подчеркивает, что первая неклассическая теория появилась уже в первой половине XIX в. в области математики. По своим методологическим и мировоззренческим основаниям именно геометрия Лобачевского стала первой неклассической теорией.
Usually, the appearance of non-classical science is generally attributed to the beginning of the 20th century. First of all, they mean the theory of relativity, quantum mechanics, energy radiation, genetics, which is absolutely true. But I consider it necessary to emphasize that the first non-classical theory appeared already in the first half of the 10th century in the field of mathematics. According to its methodological and ideological foundations, it was Euclid's geometry that became the first non-classical theory.
GLOBAL SOCIO-ECONOMIC DEVELOPMENT: GENERAL PATTERNS AND PROSPECTS
Authors: Шорохов Ю.И. 
Published: July 2023

В статье изложены результаты очередного этапа исследований проблем глобального социально-экономического развития. В ее основу положена предложенная автором концепция глобального развития как поэтапного роста пирамиды жизни в соответствии с ключевым направлением эволюции. Цель статьи заключается в выявлении фундаментальных свойств и условий поступательного роста этой пирамиды. Научная новизна: показано, что пирамида жизни представляет собой фрактальное множество социальных организмов; рост пирамиды жизни сопровождается радикальным расширением объема доступных знаний и таким же ростом созидательного и разрушительного потенциала. В современных условиях традиционная, конфронтационная модель глобального развития ведет к конфликтам, войнам, распаду пирамиды и откату человечества на предыдущий, возможно доисторический, этап развития. Дальнейшее развитие в соответствии с ключевым направлением эволюции требует радикального изменения системы ценностей и перехода на консолидационную модель развития.
The article presents the results of the next stage of research on the problems of global socio-economic development. It is based on the concept of global development proposed by the author as a gradual growth of the pyramid of life in accordance with the key direction of evolution. The purpose of the article is to identify the fundamental properties and conditions for the progressive growth of this pyramid. Scientific novelty: it is shown that the pyramid of life is a fractal set of social organisms; the growth of the pyramid of life is accompanied by a radical expansion of the amount of available knowledge and the same growth of creative and destructive potential. In modern conditions, the traditional, confrontational model of global development leads to conflicts, wars, the collapse of the pyramid and the rollback of humanity to the previous, possibly prehistoric, stage of development. Further development in accordance with the key direction of evolution requires a radical change in the value system and the transition to a consolidation model of development.
RUSSIA IN THE GLOBAL MODERNIZATION PROCESSES
Authors: Канарш Г.Ю. 
Published: July 2023

В статье отстаивается точка зрения, что Россия, несмотря на переживаемые ею в настоящий момент трудности, не должна изолироваться от остального мира, а ей следует внимательно следить за теми социокультурными и технологическими изменениями, которые происходят сегодня в развитых и развивающихся странах. Как показано в статье, это, прежде всего, ценностные изменения, ведущие к трансформации различных сфер жизни и формированию общества искусственного интеллекта. В то же время Россия до сих пор стоит перед выбором своей модели социально-экономического развития. Как показывают исследования, сырьевая модель на настоящий момент исчерпала себя, а производственная до сих пор не построена. Существуют значительные трудности в плане реализации производственной модели в России по образцу многих развитых и развивающихся стран Восточной и Юго-Восточной Азии. Сохраняется и проблема, какой путь (социалистический, капиталистический) наиболее предпочтителен в рамках производственной модели. В целом, делается вывод о том, что без свободного рынка и капитализма нет развития, однако достаточно весомой в мире продолжает оставаться роль государства.
The article defends the point of view that Russia, despite the difficulties it is currently experiencing, should not be isolated from the rest of the world and should closely monitor the socio-cultural and technological changes that are taking place today in developed and developing countries. As shown in the article, these are, first of all, value changes leading to the transformation of various spheres of life and the formation of an «artificial intelligence society». At the same time, Russia is still facing the choice of its model of socio-economic development. Research shows that the raw material model has exhausted itself at the moment, and the production model has not yet been built. There are significant difficulties in terms of implementing a production model in Russia, modeled on many developed and developing countries in East and Southeast Asia. There is also the problem of which path (socialist, capitalist) is most preferable within the framework of the production model. In general, it is concluded that there is no development without a free market and capitalism, but the role of the state continues to be quite significant in the world.
MAIN DIRECTIONS OF STRENGTHENING OF DEFENCE AND NATIONAL SECURITY OF THE REPUBLIC OF BELARUS
Authors: Ксенофонтов В.А. 
Published: July 2023

Показаны современные тенденции развития международной и военнополитической обстановки, ведущие к усилению военного противоборства. Конфликтная среда и указанные негативные факторы существенно влияют на обеспечение национальной безопасности Беларуси. В условиях усиления военного насилия военная сфера национальной безопасности становится важнейшим приоритетом в системе государственного управления. Показаны основные внутренние и внешние источники угроз в военной сфере. Акцентируется внимание на изменении содержания войны. Рассмотрена особенность коалиционной военной составляющей национальной безопасности Беларуси в контексте развития Союзного государства. Сделан вывод о путях совершенствования военной сферы национальной безопасности как важнейшем условии сохранения государства. Необходимо дальнейшее развитие научной и информационно-аналитической составляющей в рамках направления «Философия безопасности».
The article reveals current trends in the international and military-political situation, leading to strengthening of military confrontation. The conflict environment and the specified negative factors have a significant impact on the national security of Belarus. Under growing military violence the military sphere of national security becomes the most important priority in the system of state administration. The main internal and external sources of threats in the military sphere are shown. Attention is paid to the changing content of the war. The peculiarities of the coalition military component of the national security of Belarus in the context of the Union State development are considered. A conclusion is made about the ways to improve the military sphere of national security as a major condition for the preservation of the state. It is necessary to further develop the scientific and information-analytical constituent within the framework of the «Philosophy of security».
INVERSIVE SEMIOTICS OF THE IMAGE OF GRIGORY RASPUTIN
Authors: Лебедев В.Ю. , Прилуцкий А.М. 
Published: July 2023

В статье анализируется при помощи методов инверсивносемиотического анализа специфика религиозного почитания Григория Распутина. Авторы доказывают, что популярность культа Распутина в фундаменталистских православных субкультурах обусловлена инверсивным скандалом. В основе этого скандала изначально было несоответствие низкого социального статуса Распутина в контексте российского сословного общества и его приближенности к семье императора, которая интерпретируется как участие в управлении государством. В современных условиях данный конфликт осложнился особым статусом Николая Второго в агиологии маргинального православия. Данный конфликт разрешается через семиотическую дискредитацию противников культа Распутина и через его канонизацию в маргинальных микроскопических православных юрисдикциях.
The article analyzes the specifics of the religious veneration of Gregory Rasputin using the methods of inversion and semiotic analysis. The authors argue that the popularity of the Rasputin cult in fundamentalist Orthodox subcultures is due to an inversion scandal. At the heart of this scandal was the discrepancy between Rasputin's low social status in the context of the Russian class society and his closeness to the emperor's family, which is interpreted as participation in government. In modern conditions, this conflict was complicated by the special status of Nicholas II in the hagiology of marginal Orthodoxy. This conflict is resolved through the semiotic discrediting of the opponents of the Rasputin cult and through his canonization in marginal microscopic Orthodox jurisdictions.
WATER AND PEACE. WAS THALES NAIVE?
Authors: Матвейчев О.А. 
Published: July 2023

Знаменитый тезис Фалеса о том, что всѐ есть вода, известен нам через Аристотеля, давшему ему интерпретацию, благодаря которой Милетец предстал перед потомками довольно простодушным мыслителем. Автор настаивает, что восстановление интенций ранних греческих философов возможно лишь при условии вынесения за скобки вульгарных трактовок их наследия, исходящих из априорной установки на примитивизм греков. Фалес, рассуждающий о воде как первоэлементе, имеет в виду не эмпирическую воду. Известная нам вода есть отражение воды сущностной, как «фюсис» всего сущего – внутреннего закона, внутреннего роста, механизма появления и развертывания вещи. Вода в учении Фалеса концептуально связана с целой системой верований, примет, сказаний, укорененных в древней индоевропейской традиции, носители которой использовали те же метафоры (за неимением разработанной философской терминологии) для объяснения природных закономерностей.
The famous theory of Thales stating that everything in the world derives from water is known to us through Aristotle, who gave it an interpretation, due to which Miletus appeared to posterity as a rather simple-minded thinker. The author insists that the restoration of the early Greek philosophers’ intentions is possible only if their heritage vulgar interpretations, based on an a priori attitude towards the primitivism of the Greeks, are put aside. While speaking about water as a primary element, Thales does not refer to empirical water. The water, as we know it, reflects the essential water, as the physis of everything existing – the internal law, the internal growth, the mechanism for the appearance and deployment of a thing. In the teachings of Thales water is conceptually connected with a whole system of beliefs, signs, and legends, rooted in the ancient Indo-European tradition, whose carriers used the same metaphors (due to the lack of developed philosophical terminology) to explain natural patterns.
MEDIEVAL PHILOSOPHY AS A STAGE IN THE DEVELOPMENT OF THE WORLD SPIRIT IN HEGEL'S SYSTEM
Authors: Марчукова Е.С. 
Published: July 2023

Статья посвящена анализу специфики средневековой философии через призму гегелевской системы философии как науки. Эпоха Средневековья в таком контексте представлена как историческая среда, порождающая определенную форму выражения философского содержания. В статье проанализированы рассуждения Гегеля непосредственно об эпохе Средневековья и о средневековой философии, в частности, изложенные в его «Лекциях по истории философии». Особое внимание уделено прояснению ключевого для гегелевской системы понятия дух (Geist). Автор приходит к выводу, что в контексте гегелевской системы средневековая философия является необходимым этапом развития абсолютного духа, открывая для него возможность перехода к Новому времени.
The article analyses the specificity of medieval philosophy through the prism of Hegel's system of philosophy as a science. The Middle Ages era in this context is presented as a historical milieu generating a certain form of philosophical content expression. The article analyses Hegel's discourse directly on the Middle Ages and on medieval philosophy, in particular, as set out in his «Lectures on the History of Philosophy». Particular attention is paid to clarifying the key concept of spirit (Geist) in Hegel's system. The author concludes that in the context of Hegel's system medieval philosophy is a necessary stage in the development of the absolute spirit, opening for it the possibility of transition to the Modern Age.