bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurotoxicology of alcohol: a bibliometric and science mapping analysis
Authors: Mendes Paulo Fernando Santos , Baia-da-Silva Daiane Claydes , Melo Wallacy Watson Pereira , Bittencourt Leonardo Oliveira , Souza-Rodrigues Renata Duarte , Fernandes Luanna Melo Pereira , Maia Cristiane do Socorro Ferraz , Lima Rafael Rodrigues 
Published: August 2023

Alcohol consumption is common in many societies and has increased considerably, resulting in many socioeconomic and public health problems. In this sense, studies have been carried out in order to understand the mechanisms involved in alcohol consumption and related harmful effects. This study aimed to identify and map the knowledge and to perform bibliometric analysis of the neurotoxicology of alcohol based on the 100 most cited articles. A search was carried out in the Web of Science Core Collection database and information was extracted regarding the journal, authors, keywords, year of publication, number of citations, country and continent of the corresponding author. For each selected manuscript, the study design, alcohol exposure model, dose, period of exposure, and effect on the central nervous system and research hotspots were mapped. The journal with the highest number of publications was Alcoholism: Clinical and Experimental Research (n = 11 papers), the author who contributed the most was Crews FT (n = 8 papers), the studies had a total of 288 keywords and 75% of the publications were from the United States of America. The experimental studies evaluated the effects of prenatal and postnatal exposure and were conducted in rats and mice using doses ranging from 2.5 to 14 g/kg/day, with administration by subcutaneous, intraperitoneal, intragastric, or inhalation route or with free access through drinking bottles. Among the studies mapped, the oldest one (1989) aimed to understand the systemic damage and mechanisms of action involved, while the most recent focused on understanding the receptors and mechanisms involved in addiction, as well as genetic factors. Our results show the panorama of the most widespread scientific production in the scientific community on the neurotoxicology of ethanol, a high prevalence was observed in studies that addressed fetal alcohol syndrome and/or the effects of ethanol on neurodevelopment.
Comparative analysis of tumor biology and prognosis in mucinous and signet-ring cell colon cancers versus classical adenocarcinoma
Authors: Liu Yang , Yin Wenxin , Li Xiaoxia , Li Bowen , Liu Fang , Kang Pengcheng 
Published: August 2023

Background: Limited information is currently available on the natural history and prognosis of two distinct histological subtypes of adenocarcinoma (AC) in the colon: mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC). Therefore, the aim of this study is to examine the clinicopathological characteristics of colon MAC and SRCC, comparing them to classical AC, using a large cohort of cases from the United States.Methods: Patients diagnosed with colon AC, MAC, or SRCC from the SEER database between 2000 and 2018 were included in our study. Incidence trends, patient demographics, tumor characteristics, treatment, and survival were analyzed.Results: In our study, we analyzed a total of 310,813 patients with colon cancers, including 271,382 cases of classical AC, 34,750 cases of MAC, and 4,681 cases of SRCC. Over the study period, we observed a decline in the age-adjusted incidence rates of colon AC, MAC, and SRCC. Notably, the MAC and SRCC cohorts differed significantly from AC in terms of patient characteristics, tumor locations, and treatment patterns. Patients with MAC and SRCC had poorer survival outcomes compared to those with AC. Factors associated with worse survival included older age, male sex, poorly differentiated tumors, advanced stage, and the presence of MAC or SRCC histology. On the other hand, surgical intervention was associated with improved survival.Conclusion: Our study underscores the significance of recognizing the distinct features and outcomes associated with different histological subtypes of colon cancer. Further research is warranted to delve into the underlying biological traits that contribute to these differences and to develop more tailored treatment strategies.
Breaking the cycle of emotional flooding: the protective role of women’s emotional intelligence in couple’s conflict
Authors: Berenguer-Soler María , García del Castillo-López Álvaro , Pineda David 
Published: August 2023

IntroductionOne of the most damaging aspects, both for people’s well-being and for close relationships, is conflict. Beyond different stressors, the emotions evoked, their regulation and an appropriate conflict resolution strategy will reduce negative consequences. Emotional Intelligence facilitates social relationships, but little applied research has been done on the relationship with couple conflict and emotional flooding, particularly from the perspective of women. Therefore, the present study analyzes the role of Perceived Emotional Intelligence (PEI) and the mediating effect of Positive Conflict Resolution strategies (PCR) in couples’ conflicts from women’s perspective, examining its effect on Emotional Flooding (EF) and Satisfaction.MethodsThrough a cross-sectional design, the relationships between variables were analyzed using group comparisons and means of a structural equation model (SEM) in a sample of 692 women.ResultsSignificant differences were found between the groups by age, length of relationship, and motherhood. The SEM revealed a good fit. PEI predicted 71.8% of the variance in EF and 35% in Satisfaction through PCR and Conflict.
Using iterative random forest to find geospatial environmental and Sociodemographic predictors of suicide attempts
Authors: Pavicic Mirko , Walker Angelica M. , Sullivan Kyle A. , Lagergren John , Cliff Ashley , Romero Jonathon , Streich Jared , Garvin Michael R. , Pestian John , McMahon Benjamin , Oslin David W. , Beckham Jean C. , Kimbrel Nathan A. , Jacobson Daniel A. 
Published: August 2023

IntroductionDespite a recent global decrease in suicide rates, death by suicide has increased in the United States. It is therefore imperative to identify the risk factors associated with suicide attempts to combat this growing epidemic. In this study, we aim to identify potential risk factors of suicide attempt using geospatial features in an Artificial intelligence framework.MethodsWe use iterative Random Forest, an explainable artificial intelligence method, to predict suicide attempts using data from the Million Veteran Program. This cohort incorporated 405,540 patients with 391,409 controls and 14,131 attempts. Our predictive model incorporates multiple climatic features at ZIP-code-level geospatial resolution. We additionally consider demographic features from the American Community Survey as well as the number of firearms and alcohol vendors per 10,000 people to assess the contributions of proximal environment, access to means, and restraint decrease to suicide attempts. In total 1,784 features were included in the predictive model.ResultsOur results show that geographic areas with higher concentrations of married males living with spouses are predictive of lower rates of suicide attempts, whereas geographic areas where males are more likely to live alone and to rent housing are predictive of higher rates of suicide attempts. We also identified climatic features that were associated with suicide attempt risk by age group. Additionally, we observed that firearms and alcohol vendors were associated with increased risk for suicide attempts irrespective of the age group examined, but that their effects were small in comparison to the top features.DiscussionTaken together, our findings highlight the importance of social determinants and environmental factors in understanding suicide risk among veterans.
Social-psychological determinants of hormonal contraceptive use intentions among adolescent girls in the Bono East Region of Ghana
Authors: Boamah-Kaali Ellen Abrafi , Ruiter Robert A. C. , Owusu-Agyei Seth , Asante Kwaku Poku , Mevissen Fraukje E. F. 
Published: August 2023

IntroductionThe correct and consistent use of hormonal contraceptive (HC) methods by sexually active adolescent girls can prevent pregnancy and avert the health and social consequences of unwanted pregnancy for both the mother and her child. Despite these benefits, research shows that HC use is rather low among adolescent girls globally and especially among those in low and middle-income countries. This study was carried out to assess the social-psychological determinants of HC use intentions among adolescent girls and young women.MethodsA cross-sectional survey was conducted among 1,203 young women aged 15–24 years from 70 communities within the Kintampo North Municipality and Kintampo South District in the Bono-East Region of Ghana from April 2021 to September 2021. Multiple linear regression analysis was used to identify factors associated with the intention to use HC among the entire sample of 1,203 respondents and among two sub-samples of young women based on HC use experience.ResultsAttitude toward personal HC use (β = 0.268; p &lt; 0.001), self-efficacy toward access and use of HC (β = 0.341; p &lt; 0.001), and HC use experience (β = 0.647; p &lt; 0.001) were found to be significant and unique correlates of HC use intention among the entire sample of adolescent girls. Attitude toward personal HC use and self-efficacy toward access and use of HC were also associated with HC use intention in the two sub samples significantly (p’s &lt; 0.001). In addition, among participants with no HC experience, being a Christian as opposed to participants that affiliate themselves with Islam, Traditional religion or being non-religious positively predicts future HC use (β = 0.230; p &lt; 0.01).ConclusionOur results demonstrate that different groups of adolescent girls need different interventions, focusing on different determinants for the motivation to use HC. Comprehensive sexuality education, informing all adolescent girls about the personal benefits of HC use and enhancing their skills in accessing and using HCs, can support their HC use intentions to promote their reproductive health and general wellbeing.
The effect of educational intervention based on the PEN-3 model on breast cancer screening behaviors
Authors: Shoushtari-Moghaddam Elaheh , Shahnazi Hossein , Hassanzadeh Akbar 
Published: August 2023

BackgroundBreast cancer is the most important malignancy and the main cause of cancer deaths among women worldwide. Breast cancer screening is an effective way to reduce breast cancer deaths.ObjectivesThe present study aimed to provide breast cancer screening behavior training for female teachers in Isfahan, Iran.Materials and methodsThis randomized controlled trial included 120 teachers who have randomly divided into two groups (60 in the control group and 60 in the intervention group). The data collection tool was a PEN-3 model-based questionnaire. Four 90 min training sessions were held for the intervention group to modify perception and enablers. Breast self-examination (BSE), Clinical breast exam (CBE), and mammography (MMG) were investigated in both groups before and after 6 months after the last training using SPSS20 and appropriate statistical tests.ResultsThe frequency of BSE (p = 0.02), CBE (p = 0.04), and MMG (p = 0.01) in the intervention group was significantly higher than in the control group 6 months after training. The mean scores of perception and enablers were significantly higher in the intervention group than in the control group 3 and 6 months after training (p &lt; 0.001). The logistic regression analysis indicated that perception factors were the strongest predictors of breast cancer screening behavior in teachers.ConclusionResults of the present study indicated that using the PEN-3 model in the educational intervention was effective in improving breast cancer screening behavior.
The feasibility, acceptability, cost and benefits of a “communities of practice” model for improving the quality of childcare centres: a mixed-methods study in the informal settlements in Nairobi
Authors: Nampijja Margaret , Langat Nelson , Oloo Linda , Amboka Patrick , Okelo Kenneth , Muendo Ruth , Habib Sabrina , Kiyeng Martin , Ray Anna , Abboah-Offei Mary , Kitsao-Wekulo Patricia , Kimani-Murage Elizabeth , Li Jinshuo , Elsey Helen 
Published: August 2023

BackgroundInformal childcare centres have mushroomed in the informal settlements of Nairobi, Kenya to meet the increasing demand. However, centre providers are untrained and the facilities are below standard putting children at risk of poor health and development. We aimed to co-design and test the feasibility, acceptability, cost and potential benefits of a communities of practice (CoP) model where trained community health volunteers (CHVs) provide group training sessions to build skills and improve practices in informal childcare centres.MethodsA CoP model was co-designed with sub-county health teams, centre providers and parents with inputs from Kidogo, government nutritionists and ECD experts and implemented in 68 childcare centres by trained CHVs. Its feasibility and potential benefits were measured quantitatively and qualitatively. Centre provider (n = 68) and CHV (n = 20) knowledge and practice scores before and after the intervention were assessed and compared. Intervention benefits were examined using linear regressions adjusting for potential confounding factors. We conducted in-depth interviews with 10 parents, 10 CHVs, 10 centre providers and 20 local government officials, and two focus groups with CHVs and centre providers. Qualitative data were analysed, focusing on feasibility, acceptability, potential benefits, challenges and ideas for improvement. Cost for delivering and accessing the intervention were examined.ResultsThe intervention was acceptable and feasible to deliver within existing government community health systems; 16 CHVs successfully facilitated CoP sessions to 58 centre providers grouped into 13 groups each with 5–6 centre providers, each group receiving four sessions representing the four modules. There were significant improvements in provider knowledge and practice (effect size = 0.40; p &lt; 0.05) and quality of centre environment (effect size = 0.56; p &lt; 0.01) following the intervention. CHVs’ scores showed no significant changes due to pre-existing high knowledge levels. Qualitative interviews also reported improvements in knowledge and practices and the desire among the different participants for the support to be continued. The total explicit costs were USD 22,598 and the total opportunity costs were USD 3,632 (IQR; USD 3,570, USD 4,049).ConclusionA simple model delivered by CHVs was feasible and has potential to improve the quality of informal childcare centres. Leveraging these teams and integration of the intervention into the health system is likely to enable scale-up and sustainability in Kenya and similar contexts.
Prevalence and cost of hospitalized patients with asymptomatic COVID-19 in 2020 in Spain
Authors: Álvarez-del Río Blanca , Sánchez-de Prada Laura , Álvaro-Meca Alejandro , Martín-Fernández Marta , Álvarez F. Javier , Tamayo Eduardo , Gutiérrez-Abejón Eduardo 
Published: August 2023

IntroductionCOVID-19 transmission has been characterized by the presence of asymptomatic patients. Additionally, most studies evaluating costs focus on symptomatic COVID-19 cases.ObjectiveTo describe the prevalence, characteristics, and costs of asymptomatic COVID-19 cases at admission in Spanish hospitals in 2020.MethodsA nationwide study was performed, and data of hospitalized patients were collected of the Minimum Basic Data Set in Spain during 2020. Patients with COVID-19 codes as a primary and as a secondary diagnosis at admission were selected. Variables collected included age, sex, length of stay, in-hospital death, admission, length of stay and death in intensive care unit, mechanical ventilation and ventilatory assistance. COVID-19 related hospital costs were calculated using diagnosis-related groups from the Minimum Basic Data Set. Patients and costs were disaggregated by sex, age group, intensive care unit admission and epidemic wave (first or second) and main diagnosis.ResultsA total of 14,742 patients were admitted with asymptomatic COVID-19 in Spanish hospitals representing 6.35% of all COVID-19 admitted patients. The total cost of admissions with asymptomatic COVID-19 was €105,933,677.6 with a mean cost per patient of €7,185.8 with higher mean cost in the first wave despite only 2.7% of cases were found during that time. Based on primary diagnosis, the higher number of cases of asymptomatic COVID-19 were found in “Pregnancy, childbirth and the puerperium” followed by “diseases of the circulatory system”.ConclusionsThere was a high prevalence of asymptomatic cases during screening at admission process in Spanish hospitals in 2020. The highest number of cases was found among the group of “pregnancy, childbirth, and puerperium” followed by “diseases of the circulatory system.” The higher costs might be due not only to the main pathology at admission but to the associated healthcare provisions needed in case of positive COVID-19 testing.
Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies
Authors: Ouologuem Dinkorma T. , Dara Antoine , Kone Aminatou , Ouattara Amed , Djimde Abdoulaye A. 
Published: August 2023

Malaria elimination may never succeed without the implementation of transmission-blocking strategies. The transmission of Plasmodium spp. parasites from the human host to the mosquito vector depends on circulating gametocytes in the peripheral blood of the vertebrate host. Once ingested by the mosquito during blood meals, these sexual forms undergo a series of radical morphological and metabolic changes to survive and progress from the gut to the salivary glands, where they will be waiting to be injected into the vertebrate host. The design of effective transmission-blocking strategies requires a thorough understanding of all the mechanisms that drive the development of gametocytes, gametes, sexual reproduction, and subsequent differentiation within the mosquito. The drastic changes in Plasmodium falciparum shape and function throughout its life cycle rely on the tight regulation of stage-specific gene expression. This review outlines the mechanisms involved in Plasmodium falciparum sexual stage development in both the human and mosquito vector, and zygote to oocyst differentiation. Functional studies unravel mechanisms employed by P. falciparum to orchestrate the expression of stage-specific functional products required to succeed in its complex life cycle, thus providing us with potential targets for developing new therapeutics. These mechanisms are based on studies conducted with various Plasmodium species, including predominantly P. falciparum and the rodent malaria parasites P. berghei. However, the great potential of epigenetics, genomics, transcriptomics, proteomics, and functional genetic studies to improve the understanding of malaria as a disease remains partly untapped because of limitations in studies using human malaria parasites and field isolates.
September 2020-Printed Issue
Authors:   Patient Safety Authority
Published: August 2023

<p>The fall 2020 issue of <em>Patient Safety</em> is available to read and download at no charge.</p> <p>Each issue features the latest evidence-based research, thoughtful commentaries and editorials, interviews with healthcare leaders and safety advocates, and powerful patient stories.</p> <ul> <li>An interview with Dr. Tejal Gandhi and Dr. Jeff Brady about the recently released <a title=“https://patientsafetyj.com/index.php/patientsaf/article/view/national-action-plan” href=“https://patientsafetyj.com/index.php/patientsaf/article/view/national-action-plan”>National Action Plan for Patient Safety</a> in the United States</li> <li>A global look at <a title=“https://patientsafetyj.com/index.php/patientsaf/article/view/global-fall-prevention” href=“https://patientsafetyj.com/index.php/patientsaf/article/view/global-fall-prevention”>innovative solutions to patient safety falls</a> </li> <li>A timely <a title=“https://patientsafetyj.com/index.php/patientsaf/article/view/process-failures” href=“https://patientsafetyj.com/index.php/patientsaf/article/view/process-failures”>examination of how process breakdowns</a> contribute to delays in recognizing, treating, and preventing the spread of respiratory infections, like the flu and COVID-19</li> <li>A social worker raises awareness of <a title=“https://patientsafetyj.com/index.php/patientsaf/article/view/intimate-partner-violence-pandemic” href=“https://patientsafetyj.com/index.php/patientsaf/article/view/intimate-partner-violence-pandemic”>intimate partner violence</a>, a serious problem that gets worse during periods of isolation</li> <li>A <a title=“https://patientsafetyj.com/index.php/patientsaf/article/view/surviving-covid-sidrane” href=“https://patientsafetyj.com/index.php/patientsaf/article/view/surviving-covid-sidrane”>survivor of COVID-19 shares his hospital experience</a> and recovery from the disease</li> <li>A researcher takes a close look at <a title=“https://patientsafetyj.com/index.php/patientsaf/article/view/nonsuicidal-self-injury” href=“https://patientsafetyj.com/index.php/patientsaf/article/view/nonsuicidal-self-injury”>nonsuicidal self-injury</a> among children and adolescents</li> </ul> <p>Thank you to our authors, peer reviewers, editorial board members, and Patient Safety Authority staff, who all play a part in the success of our journal and in advancing patient safety everywhere. <em>Patient Safety</em> is fully open access (no subscription fees or author fees), so please consider sending us your next original manuscript and sharing our journal with your colleagues, students, families, friends, and patients. <strong>Together we save lives.</strong></p>
Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2−/−Mice and Human Intrahepatic Cholangiocyte Organoid Models
Authors: Yao Qigu , Chen Wenyi , Yu Yingduo , Gao Feiqiong , Zhou Jiahang , Wu Jian , Pan Qiaoling , Yang Jinfeng , Zhou Lingling , Yu Jiong , Cao Hongcui , Li Lanjuan 
Published: August 2023

Primary sclerosing cholangitis (PSC) is a biliary disease accompanied by chronic inflammation of the liver and biliary stricture. Mesenchymal stem cells (MSCs) are used to treat liver diseases because of their immune regulation and regeneration-promoting functions. This study was performed to explore the therapeutic potential of human placental MSCs (hP-MSCs) in PSC through the Takeda G protein-coupled receptor 5 (TGR5) receptor pathway. Liver tissues were collected from patients with PSC and healthy donors (n = 4) for RNA sequencing and intrahepatic cholangiocyte organoid construction. hP-MSCs were injected via the tail vein into Mdr2−/−, bile duct ligation (BDL), and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) mouse models or co-cultured with organoids to confirm their therapeutic effect on biliary cholangitis. Changes in bile acid metabolic profile were analyzed by liquid chromatography/tandem mass spectrometry (LC-MS/MS). Compared with healthy controls, liver tissues and intrahepatic cholangiocyte organoids from PSC patients were characterized by inflammation and cholestasis, and marked downregulation of bile acid receptor TGR5 expression. hP-MSC treatment apparently reduced the inflammation, cholestasis, and fibrosis in Mdr2−/−, BDL, and DDC model mice. By activating the phosphatidylinositol 3 kinase/extracellular signal-regulated protein kinase pathway, hP-MSC treatment promoted the proliferation of cholangiocytes, and affected the transcription of downstream nuclear factor κB through regulation of the binding of TGR5 and Pellino3, thereby affecting the cholangiocyte inflammatory phenotype.