bluuebunny/crossref_metadata_2025_split huggingface dataset:
The free superficially-based low abdominal mini (SLAM) flap for oncoplastic breast reconstruction
Authors: Salibian Ara A. , Swerdlow Mark A. , Kondra Katelyn , Patel Ketan M. 
Published: March 2023

SUMMARY:
Volume replacement in oncoplastic breast reconstruction most commonly utilizes pedicled flaps. In thin patients with small breasts, free tissue transfer may be better-suited to preserve breast size. Evidence on microvascular oncoplastic reconstruction is limited and has often required sacrifice of potential future donor sites. The free superficially-based low abdominal mini (SLAM) flap utilizes a narrow strip of lower abdominal tissue based on superficial perfusion of the abdominal wall that is anastomosed to chest wall perforators to preserve the ability to perform future abdominally-based autologous breast reconstruction. Five patients underwent reconstruction with SLAM flaps for immediate oncoplastic reconstruction. Mean age was 49.8 and body mass index was 23.5. Tumor location was most commonly in the lower outer quadrant (40%). Average lumpectomy size was 30 grams. Two flaps were based on the superficial inferior epigastric artery and three on the superficial circumflex iliac artery. Recipient vessels included internal mammary perforators (40%), serratus branch (20%), lateral thoracic vessel branch (20%) and lateral intercostal perforators (20%). All patients underwent radiation therapy without delay and maintained volume, symmetry and contour at an average of 11.7 months after surgery. There were no cases of flap loss, fat necrosis, or delayed wound healing. The free SLAM flap allows for immediate oncoplastic breast reconstruction in thin, small-breasted patients with limited regional tissue without sacrificing future potential donor sites for autologous breast reconstruction.
The Impact of a Liver Transplant Program on the Outcomes of Hepatocellular Carcinoma
Authors: Endo Yutaka , Sasaki Kazunari , Moazzam Zorays , Woldesenbet Selamawit , Yang Jason , Araujo Lima Henrique , Alaimo Laura , Munir Muhammad Musaab , Shaikh Chanza F. , Schenk Austin , Kitago Minoru , Pawlik Timothy M. 
Published: March 2023

Objective:
We sought to evaluate the impact of liver transplantation (LT) programs on the prognosis of hepatocellular carcinoma (HCC) patients who underwent liver resection (LR) and noncurative intent treatment.

Background:
LT programs have an array of resources and services that would positively affect the prognosis of patients with HCC.

Methods:
Patients who underwent LT, LR, radiotherapy (RT), or chemotherapy (CTx) for HCC between 2004 and 2018 were included in the National Cancer Database. Institutions with LT programs were defined as those that performed 1 or more LT for at least 5 years. Centers were stratified by hospital volume. The impact of LT programs was assessed after propensity score matching to achieve covariate balance.

Results:
A total of 71,735 patients were identified, of which 7997 received LT (11.1%), 12,683 LR (17.7%), 15,675 RT (21.9%), and 35,380 CTx (49.3%). Among a total of 1267 distinct institutions, 94 (7.4%) were categorized as LT programs. Designation as an LT program was also associated with a high volume of LR and noncurative intent treatment (both P<0.001). After propensity score matching, LT programs were associated with better survival among LR and noncurative intent treatment patients. Although hospital volume was also associated with improved prognosis, LT programs were associated with additional survival benefits in noncurative intent treatment. On the other hand, no such benefit was noted in patients who underwent LR.

Conclusions:
The presence of an LT program was associated with a higher volume of LR and noncurative intent treatment. Furthermore, designation as an LT program had a “halo effect” on the prognosis of patients undergoing RT/CTx that went beyond the procedure-volume effect.
Surgical Care for Racial and Ethnic Minorities and Interventions to Address Inequities
Authors: Bonner Sidra N. , Powell Chloé A. , Stewart James W. , Dossett Lesly A. 
Published: March 2023

Objective:Racial and ethnic inequities in surgical care in the United States are well documented. Less is understood about evidence-based interventions that improve surgical care and reduce or eliminate inequities. In this review, we discuss effective patient, surgeon, community, health care system, policy, and multi-level interventions to reduce inequities and identifying gaps in intervention-based research.Background:Evidenced-based interventions to reduce racial and ethnic inequities in surgical care are key to achieving surgical equity. Surgeons, surgical trainees, researchers, and policy makers should be aware of the evidence-based interventions known to reduce racial and ethnic disparities in surgical care for prioritization of resource allocation and implementation. Future research is needed to assess interventions effectiveness in the reduction of disparities and patient-reported measures.Methods:We searched PubMed database for English-language studies published from January 2012 through June 2022 to assess interventions to reduce or eliminate racial and ethnic disparities in surgical care. A narrative review of existing literature was performed identifying interventions that have been associated with reduction in racial and ethnic disparities in surgical care.Results and Conclusions:Achieving surgical equity will require implementing evidenced-based interventions to improve quality for racial and ethnic minorities. Moving beyond description toward elimination of racial and ethnic inequities in surgical care will require prioritizing funding of intervention-based research, utilization of implementation science and community based-participatory research methodology, and principles of learning health systems.
TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning
Authors: de Calbiac Hortense , Montealegre Sebastian , Straube Marjolène , Renault Solène , Debruge Hugo , Chentout Loïc , Ciura Sorana , Imbard Apolline , Le Guillou Edouard , Marian Anca , Goudin Nicolas , Caccavelli Laure , Fabrega Sylvie , Hubas Arnaud , van Endert Peter , Dupont Nicolas , Diana Julien , Kabashi Edor , de Lonlay Pascale 
Published: March 2023

AbstractPatients with pathogenic variants in the TANGO2 gene suffer from severe and recurrent rhabdomyolysis (RM) episodes precipitated by fasting. Since starvation promotes autophagy induction, we wondered whether TANGO2-related muscle symptoms result from autophagy insufficiency to meet cellular demands in stress conditions. Autophagy functioning was analyzedin vitro, in primary skeletal muscle cells from TANGO2 patients in basal and fasting conditions. In addition, we developed a tango2 morphant zebrafish model to assess the effect oftango2knockdown (KD) on locomotor function and autophagy efficiencyin vivo. We report that TANGO2 mutations are associated with decreased LC3-II levels upon starvation in primary muscle cells, but not in fibroblasts. In zebrafish larvae,tango2knockdown induces locomotor defects characterized by reduced evoked movements which are exacerbated by exposure to atorvastatin, a compound known to cause RM. Importantly, RM features oftango2KD are also associated with autophagy and mitophagy defects in zebrafish. Calpeptin treatment, a known activator of autophagy, is sufficient to rescue the locomotor properties, thanks to its beneficial effect on autophagy functioning in zebrafish and independently to its effect on calpain activity. LC3-II levels of primary muscle cells of TANGO2 patients are also improved by calpeptin treatment. Overall, we demonstrate that TANGO2 plays an important role in autophagy, and that autophagy efficiency is critical to prevent RM, thus giving rise to new therapeutic perspectives in the prevention of these life-threatening episodes in TANGO2 pathology.
Input-specific bi-directional regulation of CA3 pyramidal cell excitability: its implications in sequence learning
Authors: Eom Kisang , Kim Yujin , Baek Seungmin , Park Alan J , Ho Won-Kyung , Lee Suk-Ho 
Published: March 2023

AbstractNeuronal excitability is a key determinant for recruitment of a neuron to an ensemble. High-frequency mossy fiber (MF) inputs induce a prolonged increase in the excitability of a CA3 pyramidal cell (called long-term potentiation of intrinsic excitability, LTP-IE), thereby weak perforant pathway (PP) inputs can induce long-term potentiation at PP synapses (PP-LTP). However, sustained hyperexcitability is detrimental, and a mechanism to reverse this primed state is necessary. Here, we show that burst firings of CA3 pyramidal cells elicited by PP or recurrent synaptic inputs reverse the MF-induced LTP-IE. Moreover, the high-frequency PP inputs to MF-primed CA3 pyramidal cells induced not only PP-LTP but also restored the high excitability state. Labeling a neuronal ensemble using c-fos promoter in animals exposed to a novel context, we found most CA3 ensemble cells exhibited increased excitability, indicative of LTP-IE. Moreover, when the animals experienced novel contexts twice with an interval, a substantial subset of putative twice-activated CA3 ensemble cells exhibited reduced excitability, implying depotentiation of LTP-IE. We developed an in silico model based on these experimental results and found that MF-induced LTP-IE and its depotentiation are critical for association of orthogonal neuronal ensembles representing temporally discontiguous events.HighlightsIt is unknown how non-overlapping ensembles are linked in the hippocampal CA3 area.Mossy fiber inputs prime CA3 pyramidal cells by enhancing dendritic excitability.Perforant pathway (PP) inputs to the primed cells induce synaptic strengthening.At the same time, the high excitability state is restored by PP inputs.This learning rule may play a key role in sequence learning in CA3 network.
Glycosylation differentially affects immune cell-specific tetraspanins CD37 and CD53
Authors: van Deventer Sjoerd , Hoogvliet Ilse A. , van de Voort Merel , Arnold Frank , van Spriel Annemiek B. 
Published: March 2023

AbstractTetraspanin proteins play an important role in many cellular processes as they are key organizers of different receptors on the plasma membrane. Most tetraspanins are highly glycosylated at their large extracellular loop, but the function of this post-translational modification remains largely unstudied. In this study we investigated the effects of glycosylation of CD37 and CD53, two tetraspanins important for cellular and humoral immunity. Broad and cell-specific repertoires of N-glycosylated CD37 and CD53 were observed in human B cells. We generated different glycosylation mutants of CD37 and CD53 and analyzed their localization, nanoscale organization and partner protein interaction capacity. Abrogation of glycosylation in CD37 revealed the importance of this modification for CD37 surface expression, whereas neither surface expression nor nanoscale organization of CD53 was affected by its glycosylation. CD37 interaction with its known partner proteins, CD20 and IL-6Rα, was not affected by glycosylation, other than via its changed subcellular localization. Surprisingly, glycosylation was found to inhibit the interaction between CD53 and its partner proteins CD45 and CD20. Together, our data show that tetraspanin glycosylation affects their function in immune cells, which adds another layer of regulation to tetraspanin-mediated membrane organization.
A novel interaction between the 5’ untranslated region of the Chikungunya virus genome and Musashi RNA binding protein is essential for efficient virus genome replication
Authors: Sun Kaiwen , Appadoo Francesca , Liu Yuqian , Müller Marietta , Macfarlane Catriona , Harris Mark , Tuplin Andrew 
Published: March 2023

AbstractChikungunya virus (CHIKV) is a re-emerging, pathogenic alphavirus that is transmitted to humans byAedes spp. mosquitoes—causing fever and debilitating joint pain, with frequent long-term health implications and high morbidity. The CHIKV replication cycle is poorly understood and specific antiviral therapeutics are lacking. In the current study, we identify host cell Musashi RNA binding protein-2 (MSI-2) as a proviral factor. MSI-2 depletion and small molecule inhibition assays demonstrated that MSI-2 is required for efficient CHIKV genome replication. Depletion of both MSI-2 and MSI-1 homologues was found to synergistically inhibit CHIKV replication, suggesting redundancy in their proviral function. Electromobility shift assay (EMSA) competition studies demonstrated that MSI-2 interacts specifically with an RNA binding motif within the 5’ untranslated region (5’UTR) of CHIKV and reverse genetic analysis showed that mutation of the binding motif inhibited genome replication and blocked rescue of mutant virus. For the first time, this study identifies the proviral role of MSI RNA binding proteins in the replication of the CHIKV genome, providing important new insight into mechanisms controlling replication of this significant human pathogen and the potential of a novel therapeutic target.
The effect of colonic pH on microbial activity and metabolite production using common prebiotics as substrates: anin vitrostudy
Authors: Xie Zhuqing , He Weiwei , Gobbi Alex , Bertram Hanne Christine , Nielsen Dennis Sandris 
Published: March 2023

AbstractThe interplay between gut microbiota (GM) and host via degradation of dietary components leading to the production of metabolites such as short-chain fatty acids (SCFAs) is affected by a range of factors including colonic pH and carbohydrate source. Here we investigate how differences in colonic pH influence GM composition and metabolite production using different substrates including inulin, lactose, Galactooligosaccharides (GOS), and Fructooligosaccharide (FOS) in anin vitrocolon setup. We investigated 3 different pH regimes (low, 5.2 increasing to 6.4; medium, 5.6 increasing to 6.8 and high, 6.0 increasing to 7.2) and found thatBacteroidesspp. decreased butBifidobacteriumspp. became abundant under low pH regimes, suggesting complex interactions of the bacterial community in the face of pH fluctuations in the colon. The butyrate producersButyricimonasandChristensenellawere enriched at higher pH conditions, where also butyrate production was increased using inulin as substrate. The relative abundance ofPhascolarctobacterium,Bacteroides, andRikenellaceaewas also increased at higher colonic pH, which was accompanied by increased production of propionate using GOS and FOS as substrate. The gastrointestinal factors are linked in a complex network, where microbial activity leads to the production of SCFAs and other compounds that influence pH, which in turn seems to influence microbial activity. Taken together, our results show that dynamic changes in colonic pH underin vitrosimulated conditions have a strong effect on gut microbial activity with SCFA production being higher at colonic pH conditions close to neutral.
How air pollution affects consumers' local brand choices: explanation from attribution and compensation tendency
Authors: Wang Yong , Meng Meijun , Li Yang , Zhou Qingjie , Cai Bofeng , Chen Shuo , Yang Dandan 
Published: March 2023

PurposeThis research aims to explore how consumers' local brand choices differ between air-polluted days and clean days, and why the difference occurs.Design/methodology/approachTwo studies were conducted. Study 1 used the longitudinal consumption data of various yogurt brands and daily air quality indexes in 2014 and 2015. Study 2 conducted three rounds of surveys on a clean day, a general air-polluted day and a seriously air-polluted day.FindingsThe findings indicate that consumers show less tendency of attribution and compensatory consumption during air-polluted days, which in turn decrease their willingness to choose local brands.Practical implicationsImplications are provided for future research and marketing practice, especially for local companies that rely heavily on local consumers, and retailers in heavy air-polluted areas.Originality/valueThis paper is the first to illustrate the influence of air pollution on consumers' local brand choices, and it extends current understanding on air pollution and consumer choices by discovering psychological process underneath to explain the effect.
Beggars can't be choosers: factors influencing intention to purchase organic food in pandemic with the moderating role of perceived barriers
Authors: Rehman Shafique Ur , Zhang Qingyu , Kubalek Jan , Al-Okaily Manaf 
Published: March 2023

PurposeThe authors examined the impact of environmental concerns, knowledge of organic/novel food, food neophobia, food neophilia, health consciousness and social norms on satisfaction toward organic food leading to the intention to purchase organic food (IPOF). Moreover, perceived barriers are used as a moderator between satisfaction toward organic food and IPOF.Design/methodology/approachPLS-SEM followed and multiple regression analysis followed for hypotheses testing. Convenience sampling is used and 497 questionnaires were used for the final analysis.FindingsEnvironmental concerns, knowledge of organic food, food neophilia, health consciousness, and social norms are positively related to satisfaction toward organic food leading to the IPOF. Food neophobia decreases satisfaction toward organic food. Moreover, perceived barriers are significantly moderate between satisfaction toward organic food and IPOF.Practical implicationsOrganic food organizations can use the findings to increase their IPOF. Moreover, academicians and practitioners can get an advantage from study outcomes.Originality/valueThis is a pioneer study that incorporates environmental concerns, knowledge of organic food, food neophobia, food neophilia, health consciousness, social norms, satisfaction toward organic food and perceived barriers to examine IPOF in light of the theory of planned behavior (TPB).
“Green” practices in the food retail sector: evidence from the Romanian market
Authors: Grosu Raluca Mariana 
Published: March 2023

PurposeWithin a Europe highly concerned about becoming a zero net greenhouse gas emission continent, and where the circular economy is strongly promoted as a proper lever in this sense, the present paper aims to raise awareness regarding best practices towards a “green” food retail sector in Romania. In a more specific regard, the “green” practices implemented by the main food retailers acting on the Romanian market are analysed, focusing on what these practices are, how they are measured and how transparent they are.Design/methodology/approachThe paper is based on desk research consisting in the identification and content analysis of the “green”-related information outlined on the food retailers' websites and in their published sustainability reports.FindingsFood retailers are concerned about becoming carbon neutral, implementing the “green” measures outlined in the paper through the lenses of waste management, minimising/eradicating plastic, reducing/eliminating food waste, energy efficiency/saving, water consumption efficiency, protecting biodiversity, transportation efficiency and compliance with standards/obtained certifications/adherence to pacts. In addition to actions, food retailers are concerned about their proper, continuous monitorization, tackling key indicators in four directions: overall impact on the environment, impact on resources, waste impact and transportation impact.Originality/valueThe paper provides a novel, exhaustive best practices guide to encourage the transition to a “greener” activity in the Romanian food retail sector, highlighting both action measures and key assessment indicators.
Development of optimal placement and sizing of FACTS devices in power system integrated with wind power using modified krill herd algorithm
Authors: Neelamkavil Pappachan Sebi 
Published: March 2023

Purpose
This study aims to intend and implement the optimal power flow, where tuning the production cost is done with the inclusion of stochastic wind power and different kinds of flexible AC transmission systems (FACTS) devices. Here, the speed with fitness-based krill herd algorithm (SF-KHA) is adopted for deciding the FACTS devices’ optimal sizing and placement integrated with wind power. Here, the modified SF-KHA optimizes the sizing and location of FACTS devices for attaining the minimum average production cost and real power depletions of the system. Especially, the objective includes reserve cost for overestimation, cost of thermal generation of the wind power, direct cost of scheduled wind power and penalty cost for underestimation. The efficiency of the offered method over several popular optimization algorithms has been done, and the comparison over different algorithms establishes proposed KHA algorithm attains the accurate optimal efficiency for all other algorithms.

Design/methodology/approach
The proposed FACTS devices-based power system with the integration of wind generators is based on the accurate placement and sizing of FACTS devices for decreasing the actual power loss and total production cost of the power system.

Findings
Through the cost function evaluation of the offered SF-KHA, it was noted that the proposed SF-KHA-based power system had secured 13.04% superior to success history-based adaptive differential evolution, 9.09% enhanced than differential evolution, 11.5% better than artificial bee colony algorithm, 15.2% superior to particle swarm optimization and 9.09% improved than flower pollination algorithm.

Originality/value
The proposed power system with the accurate placement and sizing of FACTS devices and wind generator using the suggested SF-KHA was effective when compared with the conventional algorithm-based power systems.
A cross-platform recommendation system from Facebook to Instagram
Authors: Chang Chia-Ling , Chen Yen-Liang , Li Jia-Shin 
Published: March 2023

PurposeThe purpose of this paper is to provide a cross-platform recommendation system that recommends the most suitable public Instagram accounts to Facebook users.Design/methodology/approachWe collect data from both Facebook and Instagram and then propose a similarity matching mechanism for recommending the most appropriate Instagram accounts to Facebook users. By removing the data disparity between the two heterogeneous platforms and integrating them, the system is able to make more accurate recommendations.FindingsThe results show that the method proposed in this paper can recommend suitable public Instagram accounts to Facebook users with very high accuracy.Originality/valueTo the best of the authors’ knowledge, this is the first study to propose a recommender system to recommend Instagram public accounts to Facebook users. Second, our proposed method can integrate heterogeneous data from two different platforms to generate collaborative recommendations. Furthermore, our cross-platform system reveals an innovative concept of how multiple platforms can promote their respective platforms in a unified, cooperative and collaborative manner.