bluuebunny/crossref_metadata_2025_split huggingface dataset:
The levels of hypoxia- and angiogenesis-related regulators and matrix metalloproteinase 9 activity in tear fluid of patients with non-penetrating ocular traumas
Authors: Gavrylyak I.V. , Greben N.K. , Bilous V.L. , Korsa V.V. , Zhaboiedov D.G. , Ağca C.A. , Tykhomyrov A.O. 
Published: January 2023

This article was focused on the evaluation of protein biomarkers related to thrombosis, hypoxia, angiogenesis, and tissue remodeling in tear fluid of patients with non-penetrating corneal trauma. 32 patients with non-penetrating corneal injures were enrolled in the study, the control group consisted of 15 healthy patients. Samples of tear fluid were collected from the patients and control volunteers with the use of a disposable end micropipette. Protein levels of D-dimer, hypoxia-inducible factor 1α (HIF-1α), angiostatins, and matrix metalloproteinase 9 (MMP-9) in tear fluids were determined by western blot analysis. Proteolytic activity values of MMP-9 were measured by gelatin zymography. Results of western blot and zymography assay were calculated by densitometry analysis and expressed as arbitrary units. Significant increase of D-dimer and HIF-1α levels in tear fluid of patients with injured cornea by 7.3 (p<0.05) and 56 (p<0.001) folds, respectively was shown, compared with control, indicating thrombotic events and hypoxia condition to be involved in pathogenesis of ocular trauma. Dramatically elevated levels/activity of MMP-9 enzyme (by 105 folds vs. control, p<0.001) suggests intense tissue remodeling and degradation of extracellular matrix in the damaged cornea. Up-regulation of angiostatin level, products of proteolytical cleavage of plasminogen, in tear fluid collected from patients with traumatic eye in comparison with healthy volunteers (by 7.3 folds, p<0.05), could represent an adaptive mechanism, which counteracts excessive hypoxia-induced neovascularization of injured cornea. It is summarized that there was a strong association between elevation of D-dimer, HIF-1α, angiostatins, and MMP-9 levels suggesting thrombosis- and hypoxia-mediated mechanisms triggering wound healing of injured cornea. The findings of this study are novel and provide a basis for further investigations of the reparation mechanisms during non-penetrating ocular trauma. Studied proteins of tear fluid can serve as relevant biomarkers of corneal wound healing and are appropriate for diagnostic and prognostic purposes.
Implementation of the principles of the scientific concept “Medicine of borderline states” regarding donosological diagnosis and overcoming the risks of health deterioration in student youth
Authors: Korobchanskyi V.O. , Sarkis-Ivanova V.V. , Bohachova O.S. , Oliinyk Y.O. , Biеleсka S.V. 
Published: January 2023

Today, the methodological basis of disease pre­vention among various categories of the population, including students, is an innovative area of medical science and health care practice, namely medicine of borderline conditions. The development of a system of prenosological diagnosis of pathological conditions in young students and their hygienic correction for disease prevention are important both from a scientific and practical point of view. The study was conducted in the conditions of a natural experiment on the basis of three types of educational institutions, at the place of study of representatives of both sexes aged 14 to 23 years, adolescents and yound adults. In order to achieve the relevant objectives, the study used the following methods: analytic addressed at the study of educational programs, curricula, schedules, profile and regulatory documents; sanitary-hygienic; psychophysiological; psychological, statistic. Set of risk factors related to the educational process among young people studying in three types of educational institutions – secondary educational institutions, higher educational institution, Professional Agrarian Lyceum was analyzed. It is established that unfavorable living conditions affect donosological mental states of asthenic, hypochondriac and depressive nature.
SMART CAMPUS: Ecosistema digital de internet de las cosas (IoT) como factoría de aprendizaje, conocimiento y transferencia.
Authors: Martínez Ruiz Ignacio 
Published: January 2023

La Agenda Europea 2030, para cumplir con los Objetivos de Desarrollo Sostenible (ODS), establece un compromiso de mejorar la eficiencia energética en más del 30% antes de 2030. Ante este reto, la iniciativa Smart Campus de la Universidad de Zaragoza (sensorizar.unizar.es) constituye un ecosistema de Internet de las Cosas (IoT) para “medir – analizar – decidir y actuar” con el que diseñar entornos inteligentes (digital twins) como factoría de formación, concienciación y dinamización de espacios urbanos sostenibles en el ámbito de la educación digital, la eficiencia energética y las energías renovables.
En los últimos 25 años se ha trabajado mucho en simulación pero menos en experimentación y, para entender los campus universitarios como laboratorios de aprendizaje, esta iniciativa Smart Campus permite medir (niveles de CO2, temperatura, humedad, consumos, etc.), aprender de los edificios y sus instalaciones, y analizar todo tipo de información para tomar decisiones basadas en datos que permitan seguir avanzando para reducir el consumo y el impacto ambiental, mejorar el confort y, especialmente en la situación actual de pandemia, aumentar la seguridad para la salud de la personas caminando hacia un concepto innovador de smart campus.
L’éducation sentimentale dans" Le Fugitif" de Nikolaï Doubov
Authors: Chekalov Kirill 
Published: January 2023

L’article est centré autour de l’oeuvre de Nicolas Doubov, un des plus remarquables écrivains soviétiques pour la jeunesse, dont les romans sont presque méconnus par la génération 2000. Dans son meilleur roman, Le Fugitif , paru en 1966 (déclin du dégel dans la culture soviétique), Doubov brosse un tableau très critique de la vie provinciale peu conforme aux principes du réalisme socialiste (alcoolisme, philistinisme, hypocrisie...). Le protagoniste, Yourka, jette un défi aux philistins qui l’entourent et quitte sa famille – pour la rejoindre (enfant prodige !) lorsque son père a de gros ennuis. Son éducation sentimentale obéit donc à la logique chrétienne, chose tout à fait exceptionnelle pour la littérature soviétique adressée aux enfants.
Mots-clé : dégel, roman, adultère, alcoolisme, l’enfant prodigue, philistinisme.
Le deuil dans les récits animistes
Authors: Katagi Tomotoshi 
Published: January 2023

Le deuil se retrouve au cœur de nombreux récits pour enfants, dont les tentatives d’exprimer ou inhiber la souffrance se mêlent, dans le monde occidental, fréquemment à des réflexions chrétiennes. Dans notre travail, en revanche, on se penchera sur différents contes «animistes», en commençant par plusieurs versions de Cendrillon. Nous étudierons ensuite d’autres contes qui montrent un deuilréciproque partagé entre les vivants et les morts, dévoilant une tension entre homme et nature, afin denous interroger sur le rôle de la sensibilité animiste dans la littérature d’enfance.
Mots clef : deuil, Cendrillon, animisme, homme-nature, écologie.
La quête de la peur : du conte de tradition orale aux albums pour l'enfance
Authors: Charnay Bochra 
Published: January 2023

Cet article tente de cerner les multiples configurations de la peur dans un corpus constitué de contes et de légendes issus du patrimoine oral français et de leurs réécritures à destination d’un jeune lectorat. Il s’agit essentiellement des contes et légendes bretons de François-Marie Luzel et d’Émile Souvestre ainsi que du cycle « Jean sans peur », fréquent dans toutes les régions de France. L’étude met en évidence la dimension mythique de ces récits et analyse leur évolution dans les transpositions pour la jeunesse.
Mots clés : Peur, conte, légende, Luzel, Souvestre, inquiétante étrangeté, lavandière, revenant, Ankou
Məktəbyaşlı uşaqların sağlam həyat tərzinin ümumi xarakteristikası
Authors: Əsgərov M. N. , Yolçuyev S. B. 
Published: January 2023

Aktuallıq: Yetişməkdə olan nəslin hərtərəfli və harmonik inkişafının təmin edilməsi əsasən sağlam həyat tərzinin vasitəsilə həyata keçirilir. Sağlam həyat tərzinin formalaşması hərəkət fəallığının kifayət qədər olması, rasional qidalanma, gün rejiminin əməl olunması, şəxsi gigyena və zərərli vərdişlərdən imtina etmək amillərdən aslıdır.
Biz bu məsələni aktual hesab etdiyimizə görə bu problemlə bağlı tədqiqat aparmaq qərarına gəldik.
Məqsəd: Dərs günü rejimində məktəblilərdə sağlam həyat tərzinə vərdişlərin aşılanması.
Tədqiqatın təşkili vəmetodları: Tədqiqat eksperimental formada təşkil edilmişdir.Tədqiqatda ədəbiyyat mənbələrinin təhlili, sorğu və anketləşmə, pedaqoji müşahidə və eksperiment metodlarından istifadə edilmişdir.
Tədqiqatın nəticələri və müzakirə: Tədqiqat zamanı məktəblilərlə bir neçə anket sorğusu aparmışıq:

İnsan üçün sağlam həyat tərzi vacibdirmi?
Sağlam həyat tərzini hansı amillər təşkil edir?
Sağlam həyat tərzini formalaşdırmaq üçün əsasən hansı metodlardan istifadə edilməlidir?

Nəticə: Məktəbyaşlı uşaqlarda sağlam həyat tərzini formalaşdırmaq üçün ailə və məktəbin birgə fəaliyyət göstərmələri zəruridir. Bu vəzifəni həyata keçirtmək üçün müəllimlərin peşəkar ustalıqları təkmilləşdirilməli və valideynlərlə müvafiq marifləndirici işlər aparılmalıdır.
Azərbaycanda otüstü hokkeyin inkişafi və mövcud problemləri
Authors: Nuriyev Y. Q. 
Published: January 2023

Otüstü hokkeyin yaranma tarixi tam dəqiqləşməyib. Qədim Romada hokkeyə oxşar oyun təsviri, 1330-cu ildə Fransada tapılan oyun haqda yazılar belə deməyə əsas verir ki, otüstü hokkey ən qədim idman növləri sırasına daxildir.
Müasir otüstü hokkey 1908-ci ildə qeyri-rəsmi olaraq Olimpiya Oyunlarında nümayiş etdirilsə də yalnız 1928-ci ildə Amsterdamda keçirilən Oyunların proqramına kişi komandalarının mübarizəsi daxil edilib. Qadın hokkeyçilər isə bu mötəbər kompleks yarışlara yalnız 1980-ci ildə Moskvada qoşula biliblər.
Keçmiş SSRİ məkanında kişilər 1969-cu, qadınlar isə 1977-ci ildən otüstü hokkey idman növü ilə yaxından tanış olublar.
Azərbaycanda bu olimpiya idman növünün inkişafını üç mərhələyə ayırmaq olar: Birincisi - SSRİ dövrü, ikincisi - müstəqillik qazanandan sonra (1991-ci 2000-ci illər) və üçüncüsü isə 2001-ci ilin əvvəlindən 2015-ci ilin axırına kimi.
Metodoloji “Okkama prinsipi” və müasir idman bədən tərbyiəsi terminologiyasının ziddiyətləri
Authors: Ramazanov A. X. , Karasev A. V. 
Published: January 2023

“Okkama ülgücü” fiziki mədəniyyət nəzəriyyəsi və praktikasına1990-cı illərdə daxil edilmişdir. Məqalədə bu metodik prinsip əsasında “texnologiya” termininin əsaslı istifadəsi nəzərdən keçirilir.
Fəlsəfədə “ülgüc” sözü inanılmaz, əsassız şərhləri aradan qaldırmağa, rədd etməyə kömək edən analitik vasitədir.Təraş alətinin ülgüc, bıçaq olduğunu nəzərə alaraq bəzi prinsiplərin adlarına bu tipli təriflər əlavə olunur.
Optimasi Waktu Penyelesaian Kuota Vaksin pada Layanan Vaksinasi di Pusat Perbelanjaan dengan Simulasi Kejadian Diskrit
Authors: Hutomo Ivan Keane , Hosana Khenny , Gunawan Ivan , Hartanti Lusia Permata Sari 
Published: January 2023

Pemerintah Indonesia berjuang mengatasi pandemi COVID-19 ini dengan memberikan vaksin gratis terhadap masyarakat guna menciptakan herd immunity. Tempat penyelenggaraan vaksin yang terbatas dan desakan untuk segera menyelesaikan target vaksinasi memunculkan ide untuk menjadikan pusat perbelanjaan sebagai tempat vaksinasi massal. Pusat perbelanjaan hanya dapat menyediakan waktu yang terbatas untuk menyelenggarakan layanan vaksin. Layanan vaksin harus selesai sebelum pusat perbelanjaan beroperasi agar tidak mengganggu pengunjung pusat perbelanjaan. Studi ini bertujuan menemukan konfigurasi sistem antrean yang optimal untuk menyele­saikan kuota dosis vaksin yang diberikan pemerintah pada setiap penye­lenggaraan vaksinasi massal di pusat perbelanjaan. Studi ini dilakukan pada konfigurasi sistem antrean vaksinasi massal yang diselenggarakan di lobi Galaxy Mall 3 di Surabaya. Model simulasi kejadian diskrit dikembangkan untuk merepresentasikan sistem nyata dan mengevaluasi konfigurasi sistem antrean vaksinasi booster. Tiga usulan skenario perbaikan yang aplikatif telah diuji. Hasilnya, skenario 3 (kombinasi skenario 1 dan skenario 2) yakni meng­gandakan kapasitas booth 4 dan mengurai penumpukan di ruang tunggu luar dengan meningkatkan ukuran kelompok peserta vaksin yang masuk dari 6 menjadi 9 merupakan strategi operasional yang paling efektif untuk mening­katkan performa sistem antrean. Waktu yang dibutuhkan untuk menyelesaikan 250 dosis vaksin turun sebesar 45% dari 2,5350 jam pada kondisi awal menjadi 1,3989 jam pada skenario 3.
Resource-saving technologies for utilization of highly mineralized acidic waste from the ionite part of the combined water treatment plant at the Sterlitamak thermal power plant
Authors: Vlasova A. Y. 
Published: January 2023

PURPOSE. Development of technological solutions to reduce the amount of wastewater and reuse them in the cycle of the modernized water treatment plant at the Sterlitamak thermal power plant.METHODS. To achieve this goal, the methods of system analysis of the chemicaltechnological system were used, the sources and transformation of pollutants were determined.RESULTS. To date, Russia has experience in the disposal of wastewater from water treatment plants of energy enterprises. Basically, this method is based on neutralization with the use of various additional chemical reagents. As a result of the analysis, variants of technological schemes of a modernized water treatment plant were presented, where the concentrate after the reverse osmosis installation undergoes additional purification with the use of H- and Nacationite filters with joint or local use. The variant of the technological scheme will directly depend on the qualitative and quantitative composition of wastewater. A gypsum reactor is provided for the disposal of acidic waste regeneration solution, where gypsum is obtained as a product. These technological schemes make it possible to purify the wastewater of the installation and reuse it. These schemes are low-cost and are promising directions for the development of stations. conclusion. The developed technological solutions do not require the purchase of expensive chemicals and equipment, but only require the re-binding of equipment and the presence of a contact tank. These technologies are resource-saving, as a result, the consumption of raw water is reduced due to the reuse of waste, i.e. the cycle is low-flow. In recent decades, many industries have switched to a low-waste policy, since wastewater carries a large amount of valuable substances that can be recycled and reused.
Comparison of Psychological Well-Being of Surgical and Non-Surgical Specialty Physicians Working in a Hospital using the General Health Questionnaire-28 (GHQ-28)
Authors: EROĞLU Tolga , ALTUĞ Defne , ERDEM Alagül , YERLİKAYA İlkim Nira , BAKIRCI Nadi 
Published: January 2023

Purpose: Psychological well-being of a physician affects the physician’s mental and physical health, even the patient-physician relationship. This article aims to evaluate and compare the psychological well-being of surgeons and internists in a hospital and to investigate the relationship with relevant variables.
Method: Full-time physicians working in a private hospital in Istanbul between 15-30 April 2019 participated in this study. With General Health Questionnaire-28 (GHQ-28), the frequency of Probable Psychiatric Cases (PPCs) was determined. The GHQ-28 results were compared with the physician’s specialty, demographic information, and answers to the job satisfaction questions that we prepared. Moreover, the relationship between these answers and the physician’s specialty was evaluated.
Results: 84 (37.3%) of 225 physicians (Confidence Level= 95%, Margin of Error= 8%) participated in the study. 19 (22.6%) physicians were found a PPC with a GHQ-28 score of ≥5. Of these 19 people, 11 were surgeons and 8 were internists. The frequency of PPCs was found as 25.6% in surgeons and 19.5% in internists (p>0.05). While 90.8% of non-PPCs were satisfied with their working environment, this rate was 68.4% in PPCs (p=0.038). There was no significant difference in the answers to job satisfaction questions between the surgeons and internists (p>0.05).
Conclusion: There was no relationship between the physician’s specialty and being a PPC. A relationship was found between not being a PPC and being satisfied with the physician’s working environment and it should be considered in the evaluation of the mental health of the physicians.
Research Capacity for Prevention and Control of Non-communicable Diseases and their Risk Factors in Nepal: Findings of a Needs Assessment Study
Authors: Oli N. , Pradhan P. M. S. , Sagtani R. A. , Shrestha A. , Jaacks L. M. , Karmacharya B. M. , Danaei G. , Vaidya A. 
Published: January 2023

Background Despite a high burden, there are limited trainings in non-communicable disease research in Nepal.
Objective We conducted a needs assessment to assess existing research training capacity in academic health institutions of Nepal for the prevention and control of noncommunicable diseases, identify gaps in research, and explore the feasibility of developing research training program in Nepal targeting non-communicable diseases.
Method We did mixed-method research and reviewed academic institution curricula and scientific articles authored by Nepali researchers. We conducted 14 Focus Group Discussions with bachelor and masters level students of public health and community medicine; 25 In-depth Interviews with department heads and faculties, and government stakeholders. We surveyed medical and public health students on their research knowledge and skills development.
Result Research methodology component was addressed differently across academic programs. One-third (33.7%) of students expressed lack of skills for analysis and interpretation of data. They felt that there is a wide scope and career-interest in non-communicable diseases research in Nepal. However, specific objectives in the curriculum and practical aspects regarding non-communicable diseases were lacking. Most of the non-communicable diseases research in Nepal are prevalence studies. Lack of funding, conflicting priorities with curative services, and inadequate training for advanced research tools were reported as major barriers.
Conclusion Nepal must strengthen the whole spectrum of research capacity: epidemiological skills, research management, and fund development. Generation of a critical mass of non-communicable disease researchers must go together with improved funding from the government, non-governmental, and external funding organizations.
Awareness and Knowledge of Glaucoma and their Associated Factors among Staffs in a Tertiary-level Hospital in Central Nepal
Authors: Shrestha A. , Shrestha P. , Shrestha T. , Shrestha R. M. , Sujakhu D. , Dhakal K. , Thapa G. , Adhikari S. , Karki S. , Poudel L. 
Published: January 2023

Background Since glaucoma-related blindness may only be prevented with early identification and treatment, finding asymptomatic individuals in the target population is critical. It is thus important to determine the awareness and knowledge on glaucoma.
Objective To determine the knowledge and awareness on glaucoma among the staff of a tertiary level hospital in central Nepal.
Method This was a cross sectional study among the staffs of Dhulikhel Hospital who participated voluntarily in the study. The data was collected through the administration of semi-structured questionnaires. R version 4.0.3 (2020-10-10) was used for the data analysis. Categorical variables are presented as frequency (percentages) and the numerical ones are presented as mean (standard deviation). Adjusted odds ratio (AOR) with 95% confidence interval were estimated through logistic regression analysis for determining factors associated with awareness and knowledge of glaucoma.
Result A total of 107 (89.2%) participants had heard about glaucoma of which 93 (86.9%) had good knowledge and 14(13.1%) had poor knowledge on glaucoma. The mean score of knowledge was 64.1±16.9. Only 47.7% of the participants said that glaucoma also has an asymptomatic course. We could not find an association of awareness and knowledge of glaucoma with any of the selected sociodemographic variables.
Conclusion Although there was a fairly good glaucoma related awareness and knowledge among hospital staff, we found lack of understanding on some critical issues on glaucoma, mainly related to its asymptomatic nature. There is thus room for improvement in educating about glaucoma even in healthcare settings. Given the necessity of expanding glaucoma awareness in the public, hospital staff might potentially serve as messengers to the communities
Ultrasonographic Evaluation of Inferior Vena Cava: Aorta Index with a Cut-off Value of 1.0 as a Predictor for Hypotension after Induction of General Anesthesia; An observational study
Authors: Shakya S. , Sharma B. , Singh J. , Ranjit S. 
Published: January 2023

Background Hypotension after induction of general anesthesia (GA) is common due to pre-existing hypovolemia and has adverse effects on organ function. Out of several methods to predict post-induction hypotension, nowadays Inferior Vena Cava: Aorta (IVC: Ao) index has been studied with different cut-off values. However, limited studies have been performed in our part of the world.
Objective To evaluate the efficacy of pre-induction Inferior Vena Cava: Aorta index with a cutoff value of 1.0 for predicting the occurrence of post-induction hypotension after general anesthesia in the Nepalese population.
Method A total of 100 patients of ASA I and II, aged more than 18 years posted for elective surgeries under general anesthesia were enrolled in this cross-sectional, observational study. Ultrasonographic guided Inferior Vena Cava: Aorta index was calculated and based on a cut-off value of 1.0, two groups were formed. Seventy patients in group A with Inferior Vena Cava: Aorta index less than 1.0 and 30 patients in group B with Inferior Vena Cava: Aorta index more than 1.0 were enrolled. Vitals parameters were recorded every minute for five minutes after induction of general anesthesia. Incidence of hypotension was the primary outcome. Statistical analysis was done using student t-test, ANOVA test and Chi-square test.
Result Inferior Vena Cava: Aorta index with cut-off value of 1.0 predicted post-induction hypotension with excellent efficacy. Total 65 patients developed post-induction hypotension, out of which 63 patients had Inferior Vena Cava: Aorta index less than 1.0.
Conclusion We concluded that pre-induction Inferior Vena Cava: Aorta index with cut-off value of 1.0 have high diagnostic accuracy with high degree of sensitivity and specificity to predict hypotension after induction of general anesthesia.