bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships between drinking habits, psychological resilience, and salivary cortisol responses on the Trier Social Stress Test-Online among Japanese people
Authors: Ueno Masaharu 
Published: August 2023

Abstract
Background
This study aimed to determine whether individual differences in resilience interacted with those in alcohol consumption habits in situations involving exposure to psychosocial stressors (Trier Social Stress Test-Online; TSST-OL). Additionally, we investigated whether individuals exhibiting resilience in their psychological scale scores showed biological responses that could be interpreted as resilience in stressful situations, such as the TSST-OL. We hypothesized that there would be no association between drinking habits and stress responses in the high-resilience group. Furthermore, high drinking habits would be associated with high stress responses in the low-resilience group.

Methods
We recruited 22 and 20 individuals from the high and low-resilience groups, respectively, from among those who completed the online survey comprising the Alcohol Use Disorders Identification Test (AUDIT) and resilience scales; we excluded individuals with AUDIT scores of 15 or higher, and divided them by the median total resilience scale score. During the TSST-OL, self-rated stress measurement and saliva sample collection were performed seven times. Frozen samples were collected at the Tokyo site, and salivary hormonal (cortisol and dehydroepiandrosterone) levels were measured after transport in frozen state. Finally, 36 participants were included in the analysis of self-rated stress and cortisol levels.

Results
We observed the typical subjective stress responses to the TSST-OL. People with higher psychological scale scores for resilience traits showed significantly higher salivary cortisol levels than those with lower scores. Due to deficiencies in the survey and experimental design, the classification criteria were changed and an exploratory analysis was performed to investigate the interaction of individual differences in resilience and drinking habits. In contrast to our expectation, those with low resilience scores showed stress responses, regardless of their drinking habits. Furthermore, those with high resilience and drinking habits showed a specific insensitivity to salivary cortisol levels. Their self-rated stress scores were similar to those of other groups.

Conclusions
Our study showed the applicability of the TSST-OL in the Japanese population, the individual relationship between psychological resilience measures and biological stress responses, and a specific insensitivity in the salivary cortisol response as a result of individual differences in high resilience and drinking habits.
MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value
Authors: Leske Henning , Camenisch Gross Ulrike , Hofer Silvia , Neidert Marian Christoph , Leske Sabine , Weller Michael , Lehnick Dirk , Rushing Elisabeth Jane 
Published: August 2023

AbstractTreatment with the alkylating agent temozolomide is known to be prognostically beneficial in a subset of glioblastoma patients. Response to such chemotherapeutic treatment and the prognostic benefit have been linked to the methylation status of O6-methylguanine-DNA methyltransferase (MGMT). To date, it has not been entirely resolved which methylation pattern of MGMT is most relevant to predict response to temozolomide treatment and outcome. In this retrospective study, we compared the methylation patterns, analyzed by Sanger sequencing, of 27 isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients that survived more than 3 years (long-term survivors) with those of 24 patients who survived less than a year after initial surgery (short-term survivors). Random Forest-, Correlation-, and ROC-curve analyses were performed. The data showed that MGMT is typically methylated in long-term survivors, whereas no prominent methylation is observed in short-term survivors. The methylation status of CpGs, especially in the promoter and exon1/enhancer region correlated highly with outcome. In addition, age and temozolomide treatment were strongly associated with overall survival. Some CpGs in the enhancer region, in particular CpG 86 (bp + 154), demonstrated high values associated with overall survival in the Random Forest analysis. Our data confirm previously published prognostic factors in IDH-wildtype glioblastoma patients, including age and temozolomide treatment as well as the global MGMT methylation status. The area frequently used for decision making to administer temozolomide at the end of exon1 of MGMT, was associated with outcome. However, our data also suggest that the enhancer region, especially CpG 86 (bp + 154) is of strong prognostic value. Therefore, we propose further investigation of the enhancer region in a large prospective study in order to confirm our findings, which might result in an optimized prediction of survival in glioblastoma patients, likely linked to response to temozolomide treatment.
Analyzing protein concentration from intact wheat caryopsis using hyperspectral reflectance
Authors: Zhang Xiaomei , Hou Xiaoxiang , Su Yiming , Yan XiaoBin , Qiao Xingxing , Yang Wude , Feng Meichen , Kong Huihua , Zhang Zhou , Shafiq Fahad , Han Wenjie , Li Guangxin , Chen Ping , Wang Chao 
Published: August 2023

Abstract
Background
Winter wheat grain samples from 185 sites across southern Shanxi region were processed and analyzed using a non-destructive approach. For this purpose, spectral data and protein content of grain and grain powder were obtained. After combining six types of preprocessed spectra and four types of multivariate statistical models, a relationship between hyperspectral datasets and grain protein is presented.

Results
It was found that the hyperspectral reflectance of winter wheat grain and powder was positively correlated with the protein contents, which provide the possibility for hyperspectral quantitative assessment. The spectral characteristic bands of protein content in winter wheat extracted based on the SPA algorithm were proved to be around 350–430 nm; 851–1154 nm; 1300–1476 nm; and 1990–2050 nm. In powder samples, SG-BPNN had the best monitoring effect, with the accuracy of Rv2 = 0.814, RMSEv = 0.024 g/g, and RPDv = 2.318. While in case of grain samples, the SG-SVM model exhibited the best monitoring effect, with the accuracy of Rv2 = 0.789, RMSEv = 0.026 g/g, and RPDv = 2.177.

Conclusions
Based on the experimental findings, we propose that a combination of spectral pretreatment and multivariate statistical modeling is helpful for the non-destructive and rapid estimation of protein content in winter wheat.

Graphical Abstract
Effect of mixing at weaning and nutrient density of the weaner diet on growth performance and welfare of pigs to slaughter
Authors: González-Solé Francesc , Camp Montoro Jordi , Solà-Oriol David , Pérez José Francisco , Lawlor Peadar G. , Boyle Laura A. , Garcia Manzanilla Edgar 
Published: August 2023

Abstract
Background
Mixing pigs at weaning can compromise pig welfare and growth. Therefore, grouping littermates together may allow a diet nutrient and energy density reduction during the nursery period to reduce feed cost without affecting slaughter weight. This study investigated the combined effect of mixing and reducing dietary energy and nutrient density on growth performance, body lesions (BL), and behaviour in pigs from weaning to slaughter.

Results
Forty-eight litters [554 pigs, 11–12 pigs/litter; Danish Duroc × (Large White × Landrace)] were included in the trial. At 28 days of age, pigs were weaned and housed in nursery rooms in litter groups (INTACT, n = 24) or mixed with other litters and grouped by weight to reduce within-pen pig weight variation (MIXED, n = 24). A dietary regimen meeting pigs’ nutritional requirements (CON) and a low-density dietary regimen (LOW; -10% energy and protein) completed a 2 × 2 factorial arrangement (Mixing x Diet, n = 12). On day 74 of age, pigs moved to the grower-finisher accommodation without further mixing and all pigs received the CON dietary regimen. Mixing increased FCR by 4.0% during the nursery period (p = 0.003). Nursery pigs fed LOW experienced a growth retardation which was maintained until slaughter (-2.6 kg slaughter weight; p = 0.025). Initial differences in the coefficient of variation (CV) between MIXED (10.4%) and INTACT (17.6%; p < 0.001) pigs were reduced in CON pens but not in LOW pens (interaction p = 0.025) at the end of the nursery period. MIXED pigs had more fights and BL (p < 0.001) at weaning and showed more aggression (p = 0.003) after being moved to the grower-finisher rooms. At the end of the nursery period, MIXED pigs fed LOW showed the highest number of aggressive behaviours around the feeder (interaction; p = 0.003) and pigs fed LOW showed more damaging behaviour (p < 0.001).

Conclusions
Mixing animals at weaning had limited impact on growth performance but impaired welfare which was aggravated by energy and nutrient reduction in the nursery diet. Decreasing dietary nutrient density in the nursery stage retarded growth, which could not be compensated for during the growing-finishing period.
Unilateral neurostimulation-assisted cervical epidural anesthesia for upper limb surgeries—a case series
Authors: Diwan Sandeep , Nair Abhijit , Dongre Himaunshu , Sancheti Parag 
Published: August 2023

Abstract
Background
The role of neurostimulation-aided cervical epidural anesthesia (CEA) in shoulder surgery has been described in the literature. The use of nerve stimulators and the infusion of local anesthetic (LA) in the cervical epidural space has also been mentioned. Epidural needle rotation prior to insertion of the catheter is not described, and it is not clear if general anesthesia was administered in these cases.

Case presentation
In this case series, we performed CEA at the level of C7-T1 in 12 patients undergoing various surgeries on the proximal open shoulder and mid humerus after informed consent. Ipsilateral motor responses elicited by continuous electrical stimulation were used to identify lateralization of the epidural catheter tip. The placement of catheters was confirmed under an intraoperative image intensifier. Using the median approach at the level of C7-T1, an ipsilateral twitch was noted in all patients. Neurostimulation persisted with an advancement of stimulating catheter 3–4 cm in the cervical epidural space in all patients. A cervical radiograph confirmed the placement of an ipsilateral catheter and contrast injection there upon revealing the spread of the LA agent. All patients had successful awake shoulder and mid-humerus surgeries under sole cervical epidural anesthesia as evidenced by the absence of pain response at the surgical incision.

Conclusions
Ipsilateral CEA can be offered for unilateral upper limb surgeries. Low volumes of LA can be injected after precise placement of the tip of the catheter corresponding to the level of surgical incision.
Systematic development of a set of implementation strategies for transitional care innovations in long-term care
Authors: Fakha Amal , de Boer Bram , Hamers Jan. P. , Verbeek Hilde , van Achterberg Theo 
Published: August 2023

Abstract
Background
Numerous transitional care innovations (TCIs) are being developed and implemented to optimize care continuity for older persons when transferring between multiple care settings, help meet their care needs, and ultimately improve their quality of life. Although the implementation of TCIs is influenced by contextual factors, the use of effective implementation strategies is largely lacking. Thus, to improve the implementation of TCIs targeting older persons receiving long-term care services, we systematically developed a set of viable strategies selected to address the influencing factors.

Methods
As part of the TRANS-SENIOR research network, a stepwise approach following Implementation Mapping (steps 1 to 3) was applied to select implementation strategies. Building on the findings of previous studies, existing TCIs and factors influencing their implementation were identified. A combination of four taxonomies and overviews of change methods as well as relevant evidence on their effectiveness were used to select the implementation strategies targeting each of the relevant factors. Subsequently, individual consultations with scientific experts were performed for further validation of the process of mapping strategies to implementation factors and for capturing alternative ideas on relevant implementation strategies.

Results
Twenty TCIs were identified and 12 influencing factors (mapped to the Consolidated Framework for Implementation Research) were designated as priority factors to be addressed with implementation strategies. A total of 40 strategies were selected. The majority of these target factors at the organizational level, e.g., by using structural redesign, public commitment, changing staffing models, conducting local consensus discussions, and organizational diagnosis and feedback. Strategies at the level of individuals included active learning, belief selection, and guided practice. Each strategy was operationalized into practical applications.

Conclusions
This project developed a set of theory and evidence-based implementation strategies to address the influencing factors, along further tailoring for each context, and enhance the implementation of TCIs in daily practice settings. Such work is critical to advance the use of implementation science methods to implement innovations in long-term care successfully.
Paraspinal myositis in a patient with COVID-19 infection: a case report
Authors: Pangkanon Watsachon , Leelaviwat Natnicha , Saowapa Sakditad , Liao En-Dien , Payne J. Drew 
Published: August 2023

AbstractMyalgia is one of the most common symptoms of COVID-19 infection. With the progression of the COVID-19 pandemic, emerging cases of COVID-related myositis have been reported. However, COVID-19-related myositis of the paraspinal muscle is uncommon. We present a 66-year-old female who was admitted to the hospital for hemorrhagic shock secondary to gastrointestinal bleeding. She developed COVID-19 respiratory tract infection symptoms on the second day of admission with reported severe lower back pain 3 days later. Serum creatinine kinase level was slightly elevated, and magnetic resonance imaging (MRI) revealed paraspinal myositis.
A call for aflatoxin control in Asia
Authors: Umar Abeera , Bhatti Hamzah Shahbaz , Honey Sabyan Faris 
Published: August 2023

AbstractAflatoxins are secondary metabolites, produced by some fungal species of the genus Aspergillus, posing health and economic implications throughout the world. Developing countries in Asia usually have tropical conditions and grow crops susceptible to aflatoxin proliferation. Aflatoxin proliferation is more frequent in tropical regions due to optimal climate conditions required for their production. In general, the developing countries in Asia lack control and regulation strategies, like poor harvesting practices, improper storage and poor transportation conditions resulting in major losses from farm to fork level. A number of aflatoxin positive cases above safe limits have been reported in Asia in various commodities being consumed by the local population. This not only exposes to health issues like growth impairment, immunosuppression, hepatic disorders etc. but also result in heavy economic losses due to trade restrictions. However, rigorous aflatoxin standards mean that many nations would export their best quality food and keep contaminated food domestically, resulting in higher aflatoxin exposure in low or middle-income nations, where hepatitis prevalence is high. Aflatoxin control is needed to protect the Asian population from the risks of aflatoxins and to ensure good quality safe availability of commodities throughout the world by trade. In recent years a number of bioproducts have been introduced successfully worldwide that are safe, efficient and ecofriendly. Such initiatives may be taken in Asia as well to protect our food and feed commodities from aflatoxin contamination.
Combined use of zoophytophagous mirids for sustainable biological protection of greenhouse tomato crops
Authors: Konan Kouassi A. J. , Jaworski Coline C. , Monticelli Lucie S. , Zuma Mnqobi , Boll Roger , Kouadio Marie-France N. , Martin Thibaud , Gard Benjamin , Souriau Roselyne , Lavoir Anne-Violette , Desneux Nicolas 
Published: August 2023

AbstractTuta absoluta and Bemisia tabaci are two key worldwide tomato pests. In response to chemical control limits, the use of zoophytophagous mirid predators as biocontrol agents is being increasingly studied and proposed for the management of these pests. However, the use of some mirid species and in particular Nesidiocoris tenuis, which naturally occurs in European tomato crops, is controversial due to its ability to inflict significant damage on tomato plants (necrotic rings) in parallel of its high predation capacity. Combining other mirid species such as Macrolophus pygmaeus and Dicyphus errans with N. tenuis could reduce the population growth of T. absoluta and of B. tabaci, while maintaining N. tenuis populations below a critical crop damage threshold. In this study, we tested the effect of combining N. tenuis with M. pygmaeus (at two densities: 10 and 15 individuals per plant) and with or without D. errans (five individuals per plant) on the abundance of all insects (predators and pests) for 8 weeks. We also measured leaf damage by T. absoluta and plant and flower damage (necrotic rings, flower abortion rate) by N. tenuis. We found that the combined presence of D. errans, M. pygmaeus and N. tenuis rapidly and significantly reduced the densities of B. tabaci adults, and T. absoluta larvae and damage compared to when M. pygmaeus (with both densities) was only present with N. tenuis. The presence of D. errans was critical to reduce N. tenuis population growth and necrotic rings on tomato plants, while higher densities of M. pygmaeus density reduced the rate of aborted flowers by N. tenuis. The manipulation of M. pygmaeus densities added to the presence of D. errans could provide a sustainable solution to control multiple pests simultaneously while reducing the damaging phytophagous activity of N. tenuis in tomato crops.
Development of an Electronic Health Record–Based Clinical Decision Support Tool for Patients With Lynch Syndrome
Authors: Lau-Min Kelsey S. , Bleznuck Joseph , Wollack Colin , McKenna Danielle B. , Long Jessica M. , Hubert Anna P. , Johnson Mariah , Rochester Shavon E. , Constantino Gillain , Dudzik Christina , Doucette Abigail , Wangensteen Kirk , Domchek Susan M. , Landgraf Jeffrey , Chen Jessica , Nathanson Katherine L. , Katona Bryson W. 
Published: August 2023

PURPOSE To develop an electronic health record (EHR)–based clinical decision support (CDS) tool to promote guideline-recommended cancer risk management among patients with Lynch syndrome (LS), an inherited cancer syndrome that confers an increased risk of colorectal and other cancer types. MATERIALS AND METHODS We conducted a cross-sectional study to determine the baseline prevalence and predictors of guideline-recommended colonic surveillance and annual genetics program visits among patients with LS. Multivariable log-binomial regressions estimated prevalence ratios (PRs) of cancer risk management adherence by baseline sociodemographic and clinical characteristics. These analyses provided rationale for the development of an EHR-based CDS tool to support patients and clinicians with LS-related endoscopic surveillance and annual genetics program visits. The CDS leverages an EHR platform linking discrete genetic data to LS Genomic Indicators, in turn driving downstream clinician- and patient-facing CDS. RESULTS Among 323 patients with LS, cross-sectional adherence to colonic surveillance and annual genetics program visits was 69.3% and 55.4%, respectively. Patients with recent electronic patient portal use were more likely to be adherent to colonic surveillance (PR, 1.67; 95% CI, 1.11 to 2.52). Patients more recently diagnosed with LS were more likely to be adherent to annual genetics program visits (PR, 0.58; 95% CI, 0.44 to 0.76 for 2-4 years; PR, 0.62; 95% CI, 0.51 to 0.75 for ≥4 compared with <2 years). Our EHR-based CDS tool is now active for 421 patients with LS throughout our health system. CONCLUSION We have successfully developed an EHR-based CDS tool to promote guideline-recommended cancer risk management among patients with LS.
Improving rotational energy harvesting performance of DEGs with cam follower mechanism by optimizing cam profile
Authors: Fan Peng , Zhu Zicai , Hu Qiao 
Published: August 2023

Abstract
This letter explores feasible methods for improving the rotational energy harvesting (EH) performance of a dielectric elastomer (DE) generator with a cam follower mechanism by adjusting the time ratio of the rise segment in a cam cycle period. The theoretical analysis model of the DE-based EH device under the rectangle EH scheme is developed by considering material viscosity and leakage current and verified by the existing experimental data. On this basis, the effect of the time ratio of the rise segment in a cam cycle period on the EH performance of the DE-based EH device under the rectangle scheme is also studied for different system parameters, such as the rotational frequency of the cam, and the pre-stretch ratio and the viscoelastic parameter of the DE generator. Results show that at small viscoelastic parameter, reducing the time ratio of the rise segment in a cam cycle period can improve the harvested electrical energy, while at large viscoelastic parameter, the harvested electrical energy can increase with the increase of the time ratio of the rise segment. Conclusions can help provide guidance for the cam design in the DEG with the cam follower mechanism so as to improve the EH performance in harvesting the rotational energy.