bluuebunny/crossref_metadata_2025_split huggingface dataset:
X‐Ray‐Activated Long Afterglow Double‐Perovskite Scintillator for Detection and Extension Imaging
Authors: Zhang Nan , Zhang Rui , Xu Xieming , Wang Fang , Sun Zhicheng , Wang Shuaihua , Wu Shaofan 
Published: May 2023

AbstractX‐ray flat‐panel detectors are widely used for nondestructive detection of internal information in medical radiography and industrial applications. However, a persisting challenge is the application of radiography on highly curved 3D objects to realize flexibility and information storage for the fabrication of flexible large‐area X‐ray detectors. This study demonstrates a halide‐based double perovskite Cs2Na0.9Ag0.1LuCl6:Dy3+ by a hydrothermal reaction. The as‐prepared crystals exhibit afterglow features through a co‐doping strategy of Dy3+ and Ag+ ions. The double perovskite material with doping modification exhibits excellent scintillation properties with high sensitivity, low detection limit, and high radiation stability. In addition, flexible scintillator detectors are fabricated with an area of 8.0 × 6.0 cm2 by the blade‐coating strategy, which has a high spatial resolution of 11.2 lp mm−1@MTF = 0.2. Based on the long afterglow properties, the Cs2Na0.9Ag0.1LuCl6:Dy3+ flexible film exhibits thermoluminescence after turning off the X‐ray, thereby having strong potential for X‐ray imaging of nonflat and irregular objects.
Light Delivery, Acoustic Read‐Out, and Optical Thermometry Using Ultrasound‐Induced Mechanoluminescence and the Near‐Infrared Persistent Luminescence of CaZnOS:Nd3+
Authors: Ding Yicong , So Byoungjin , Cao Jiangkun , Langenhorst Falko , Wondraczek Lothar 
Published: May 2023

AbstractLight emission from CaZnOS:Nd3+ by high‐intensity ultrasound excitation is demonstrated. Acoustic power and duty ratio enable simultaneous control of the degree of (local) thermo‐acoustic heating in isothermal or nonisothermal conditions. The Nd‐related photoemission provides direct thermometric feedback at an absolute sensitivity on the order of 10−4 K−1, within the physiological temperature range. From the individual temperature dependence of persistent luminescence and mechanoluminescence, both effects are attributed to a heterologous de‐trapping mechanism. In addition to acoustic heating and optical thermometry, this enables optical information storage and smart labeling with optoacoustic read‐out.
A metagenomic analysis of the virome of inverted papilloma and squamous cell carcinoma
Authors: Tong Charles C. L. , Lin Xiang , Seckar Tyler , Koptyra Mateusz , Kohanski Michael A. , Cohen Noam A. , Kennedy David W. , Adappa Nithin D. , Papagiannopoulos Peter , Kuan Edward C. , Baranov Esther , Jalaly Jalal B. , Feldman Michael D. , Storm Phillip B. , Resnick Adam C. , Palmer James N. , Wei Zhi , Robertson Erle S. 
Published: May 2023

AbstractIntroductionInverted papilloma (IP) is a sinonasal tumor with a well‐known potential for malignant transformation. The role of human papillomavirus (HPV) in its pathogenesis has been controversial. The purpose of this study was to determine the virome associated with IP, with progression to carcinoma in situ (CIS), and invasive carcinoma.MethodsTo determine the HPV‐specific types, a metagenomics assay that contains 62,886 probes targeting viral genomes in a microarray format was used. The platform screens DNA and RNA from fixed tissues from eight controls, 16 IP without dysplasia, five IP with CIS, and 13 IP‐associated squamous cell carcinoma (IPSCC). Paired with next‐generation sequencing, 48 types of HPV with 857 region‐specific probes were interrogated against the tumors.ResultsThe prevalence of HPV‐16 was 14%, 42%, 70%, and 73% in control tissue, IP without dysplasia, IP with CIS, and IPSCC, respectively. The prevalence of HPV‐18 had a similar progressive increase in prevalence, with 14%, 27%, 67%, and 74%, respectively. The assay allowed region‐specific analysis, which identified the only oncogenic HPV‐18 E6 to be statistically significant when compared with control tissue. The prevalence of HPV‐18 E6 was 0% in control tissue, 25% in IP without dysplasia, 60% in IP with CIS, and 77% in IPSCC.ConclusionsThere are over 200 HPV types that infect human epithelial cells, of which only a few are known to be high‐risk. Our study demonstrated a trend of increasing prevalence of HPV‐18 E6 that correlated with histologic severity, which is novel and supports a potential role for HPV in the pathogenesis of IP.
Remediation of lead (II) ions from aqueous solution using composites of iron oxide nanoparticles immobilized on microcrystalline cellulose
Authors: Kumar Bhupender , Dahiya Amarjeet , Babu J. Nagendra , Chowhan L. Raju 
Published: May 2023

AbstractMagnetic iron oxide nanoparticles immobilized on microcrystalline cellulose (MCC) are studied for the adsorption of Pb(II) ions from an aqueous solution. Composites of iron oxide and MCC were synthesized with a 5%–20% loading of iron (w/w%). The effect of pH, concentration, and contact time was studied. The adsorption isotherms were fitted to nonlinear Langmuir, Freundlich, and Dubinin–Radushkevich (D‐R) isotherms, and kinetics were studied for pseudo‐first and second‐order kinetic fit models. Adsorption of Pb(II) ions increased with increasing pH value up to 5. Maximum adsorption of Pb(II) was observed up to 299.91 mg−1 in D‐R equilibrium for onto MCC‐Iron oxide composite for composite with iron loading of 20% at pH 5.
Character hit reaction animations using physics and inverse kinematics
Authors: Liu Pengfei , Zhou Yang , Wei Xilei , Su Qizhong , Song Weipeng , Kou Qilong , Jin Xiaogang 
Published: May 2023

AbstractCharacter hit reaction is an inherent component in game development. Natural hit reactions in games are typically achieved through the use of artist‐created hit animations and motion capture. To improve the realism of impact reactions, game developers combine physics simulation with distinct hit animations based on character statuses. However, there is currently no method that can automatically produce hit reactions based on hit information in game development. To this end, we propose a physics‐driven inverse kinematic method for generating character reaction animations. We postulate that a character's hit reactions are the result of an assault impulse spreading throughout the body and forcing the body to move. Five IK (inverse kinematics) solvers are used to control character poses. Each IK solver is used to control the movement of a different part of the body. The IK solvers, which are used to determine the positions of various bodily parts, are driven by unconstrained physics simulation. Furthermore, physics simulation with constraints is used to fine‐tune the character's movements. Experiment results show that our method outperforms Unreal Engine‐based hit animation and physics simulation.
Quinolyl‐Based PGM Metallarectangles: Antiproliferative Activity, DNA and BSA Protein Interactions, and a Molecular Docking Perspective
Authors: Golding Taryn M. , Omondi Reinner O. , Biswas Supratim , Chakraborty Suparna , Prince Sharon , Smith Gregory S. 
Published: May 2023

AbstractThe increased success of small metal‐containing molecules as pharmaceutical agents has prompted investigations into the pharmacological activity of a different class of metal‐based compounds; supramolecular coordination complexes (SCCs). Such complexes have been extensively investigated for their anticancer activity, with many displaying activities comparable or superior to available clinical chemotherapeutic drugs. Here, we evaluated a series of quinoline‐containing binuclear complexes and metallarectangles for theirin vitroanticancer activity in the hormone receptor positive MCF‐7 and triple negative MDA‐MB‐231 breast cancer cell lines. The preliminary cytotoxic screen, in the MCF‐7 cell line, revealed that the ligand (7‐chloro‐4‐(pyridin‐4‐yl)quinoline,L) and metallarectangle [{Ir(μ‐Cl)(Cp*)}4(μ‐L)2](OTf)4display superior activity to cisplatin, while [{Ru(p‐cymene)}4(μ‐η2‐η2‐C2O4)2(μ‐L)2](OTf)4was more potent than cisplatin in the triple‐negative MDA‐MD‐231 cell line. Upon evaluation in a multidose screen, ligandLand metallarectangle [{Ir(μ‐Cl)(Cp*)}4(μ‐L)2](OTf)4displayed antiproliferative activity almost two‐fold greater than cisplatin in the MCF‐7 cell line, while [{Ru(p‐cymene)}4(μ‐η2‐η2‐C2O4)2(μ‐L)2](OTf)4was over two‐times more active than cisplatin in the MDA‐MB‐231 cell line. Additionally, using the non‐tumorigenic MCF‐12 A breast epithelial cell line, the compounds demonstrate increased selectivity toward breast cancer cells over non‐tumorigenic cells. Furthermore, investigations into the interactions of ligandLand selected complexes with calf thymus DNA (CT‐DNA) and bovine serum albumin (BSA) indicate favourable binding.
Discovery and Biosynthesis of Anthrochelin, a Growth‐Promoting Metallophore of the Human PathogenLuteibacter anthropi
Authors: Büttner Hannah , Hörl Johannes , Krabbe Jana , Hertweck Christian 
Published: May 2023

AbstractVarious human pathogens have emerged from environmental strains by adapting to higher growth temperatures and the ability to produce virulence factors. A remarkable example of a pathoadapted bacterium is found in the genusLuteibacter, which typically comprises harmless soil microbes, yetLuteibacter anthropiwas isolated from the blood of a diseased child. Up until now, nothing has been known about the specialized metabolism of this pathogen. By comparative genome analyses we found thatL. anthropihas a markedly higher biosynthetic potential than other bacteria of this genus and uniquely bears an NRPS gene locus tentatively coding for the biosynthesis of a metallophore. By metabolic profiling, stable isotope labeling, and NMR investigation of a gallium complex, we identified a new family of salicylate‐derived nonribosomal peptides named anthrochelins A–D. Surprisingly, anthrochelins feature a C‐terminal homocysteine tag, which might be introduced during peptide termination. Mutational analyses provided insight into the anthrochelin assembly and revealed the unexpected involvement of a cytochrome P450 monooxygenase in oxazole formation. Notably, this heterocycle plays a key role in the binding of metals, especially copper(II). Bioassays showed that anthrochelin significantly promotes the growth ofL. anthropiin the presence of low and high copper concentrations, which occur during infections.
The Unified Redox Scale for All Solvents: Consistency and Gibbs Transfer Energies of Electrolytes from their Constituent Single Ions
Authors: Radtke Valentin , Priester Denis , Heering Agnes , Müller Carina , Koslowski Thorsten , Leito Ivo , Krossing Ingo 
Published: May 2023

AbstractWe have devised the unified redox scale EabsH2O, which is valid for all solvents. The necessary single ion Gibbs transfer energy between two different solvents, which only can be determined with extra‐thermodynamic assumptions so far, must clearly satisfy two essential conditions: First, the sum of the independent cation and anion values must give the Gibbs transfer energy of the salt they form. The latter is an observable and measurable without extra‐thermodynamic assumptions. Second, the values must be consistent for different solvent combinations. With this work, potentiometric measurements on silver ions and on chloride ions show that both conditions are fulfilled using a salt bridge filled with the ionic liquid [N2225][NTf2]: if compared to the values resulting from known pKL values, the silver and chloride single ion magnitudes combine within a uncertainty of 1.5 kJ mol−1 to the directly measurable transfer magnitudes of the salt AgCl from water to the solvents acetonitrile, propylene carbonate, dimethylformamide, ethanol, and methanol. The resulting values are used to further develop the consistent unified redox potential scale EabsH2O that now allows to assess and compare redox potentials in and over six different solvents. We elaborate on its implications.
Effect of Flexible Spacer and Alkyl Tail Length on the Liquid Crystalline Phase Behavior of Fullerene Block Molecules
Authors: Lu Huanjun , Chen Xingwei , Li Xiaohong , Sun Wenxing , Wang Ying , Tu Yingfeng 
Published: May 2023

AbstractHere the supramolecular liquid crystalline (LC) phase behavior of a series of fullerene block molecules was investigated regarding spacer length, alkyl tail length and temperature. These compounds exhibit several lamellar LC phases with different packings of self‐organized fullerene two‐dimensional (2D) crystals. With a short hexamethylene spacer, they form sandwich‐like structures with triple or quadruple fullerene layers. By increasing the spacer length to 10 or 12 carbons, a composite layers‐in‐lamella superlattice structure with alternating soft hydrocarbon single layers and fullerene single or double layers was obtained. As the molecular configurational freedom between incompatible moieties was enhanced by the elongated spacer, the required cross‐sectional fullerene‐to‐hydrocarbon ratio for the superlattice could be achieved despite of different volume fractions of the blocks. The superlattice phase range is efficiently widened by the design principle of constructing LC molecules with a long spacer, which also provides a facile way to tailor novel superstructures.
The incidence of oral cavity cancer in Iran: A systematic review and meta‐analysis
Authors: Jokar Mohammad , Namavari Negin , Moshiri Seyed Alireza , Jahromi Hossein Kargar , Rahmanian Vahid 
Published: May 2023

AbstractBackground and AimsOral cancer is now a top priority for non‐communicable illnesses and universal health care plans, according to the WHO. There is no general estimate of the incidence of oral cavity cancer in Iran, despite multiple investigations. The purpose of this study is to evaluate the age‐standardized incidence rate (ASR) of oral cavity cancers in Iran.MethodIn accordance with the MOOSE (Meta‐analyses of Observational Studies in Epidemiology) Checklist recommendations, this systematic review was conducted. PubMed/MEDLINE, Web of Science, ScienceDirect, Embase, Scopus, ProQuest, and Google Scholar were used as the international databases for the systematic literature search, while SID (Scientific Information Database), Magiran and element were used as the Iranian databases. The heterogeneity of the research will be evaluated by means of the inverse variance and Cochran Q tests, along with random‐effect models. It was determined what caused the heterogeneity using a meta‐regression model. By eliminating experiments one at a time, sensitivity analysis was used. The meta‐analysis was corrected utilizing the Trim‐and‐fill method due to the identification of noteworthy publication bias via the Egger's test and asymmetry of the funnel plot.ResultsThis research incorporated a total of 22 journal articles. The pooled ASR of oral cavity cancer for males and females was estimated at 1.96 (95% CI: 1.65–2.26) (Q statistic = 1118.09, df = 25, p < .0001, I2 = 97.8%), and 1.46 (95% CI: 1.14–1.77) (Q statistic = 2576.99, df = 26, p < .0001, I2 = 99.0%), respectively. According to the funnel plots and Egger's test, there is no evidence of publication bias in studies reporting on males (bias = 1.3220, 95% CI: −3.9571, 6.6012, p = .610), but for ASR in females, Egger's test was significant (bias = −7.6366, 95% CI: 2.2141, 13.05904, p = .008). Based on Trim‐and‐fill methods, overall ASR corrected in females was estimated to be 1.36 (95% CI: 1.05%–1.66%).ConclusionIran's oral cavity cancer incidence was lower than the global average, but owing to variables including an aging population, a rise in life expectancy, and exposure to risk factors like smoking, we anticipate an increasing trend.
High‐Efficiency Electroreduction of Nitrite to Ammonia on Ni Nanoparticles Strutted 3D Honeycomb‐Like Porous Carbon Framework
Authors: Li Xiuhong , He Xun , Yao Jie , Dong Kai , Hu Long , Chen Jie , Zhang Longcheng , Fan Xiaoya , Cai Zhengwei , Sun Shengjun , Zheng Dongdong , Hamdy Mohamed S. , Liu Qian , Luo Yonglan , Liao Yunwen , Sun Xuping 
Published: May 2023

AbstractElectroreduction of nitrite (NO2−) to ammonia (NH3) provides a sustainable approach to yield NH3, whilst eliminating NO2− contaminants. In this study, Ni nanoparticles strutted 3D honeycomb‐like porous carbon framework (Ni@HPCF) is fabricated as a high‐efficiency electrocatalyst for selective reduction of NO2− to NH3. In 0.1 M NaOH with NO2−, such Ni@HPCF electrode obtains a significant NH3 yield of 12.04 mg h−1 mgcat.−1 and a Faradaic efficiency of 95.1 %. Furthermore, it exhibits good long‐term electrolysis stability.
Operationalizing the centiloid scale for [18F]florbetapir PET studies on PET/MRI
Authors: Coath William , Modat Marc , Cardoso M. Jorge , Markiewicz Pawel J. , Lane Christopher A. , Parker Thomas D. , Keshavan Ashvini , Buchanan Sarah M. , Keuss Sarah E. , Harris Matthew J. , Burgos Ninon , Dickson John , Barnes Anna , Thomas David L. , Beasley Daniel , Malone Ian B. , Wong Andrew , Erlandsson Kjell , Thomas Benjamin A. , Schöll Michael , Ourselin Sebastien , Richards Marcus , Fox Nick C. , Schott Jonathan M. , Cash David M. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: May 2023

AbstractINTRODUCTIONThe Centiloid scale aims to harmonize amyloid beta (Aβ) positron emission tomography (PET) measures across different analysis methods. As Centiloids were created using PET/computerized tomography (CT) data and are influenced by scanner differences, we investigated the Centiloid transformation with data from Insight 46 acquired with PET/magnetic resonanceimaging (MRI).METHODSWe transformed standardized uptake value ratios (SUVRs) from 432 florbetapir PET/MRI scans processed using whole cerebellum (WC) and white matter (WM) references, with and without partial volume correction. Gaussian‐mixture‐modelling–derived cutpoints for Aβ PET positivity were converted.RESULTSThe Centiloid cutpoint was 14.2 for WC SUVRs. The relationship between WM and WC uptake differed between the calibration and testing datasets, producing implausibly low WM‐based Centiloids. Linear adjustment produced a WM‐based cutpoint of 18.1.DISCUSSIONTransformation of PET/MRI florbetapir data to Centiloids is valid. However, further understanding of the effects of acquisition or biological factors on the transformation using a WM reference is needed.HIGHLIGHTS
Centiloid conversion of amyloid beta positron emission tomography (PET) data aims to standardize results.
Centiloid values can be influenced by differences in acquisition.
We converted florbetapir PET/magnetic resonance imaging data from a large birth cohort.
Whole cerebellum referenced values could be reliably transformed to Centiloids.
White matter referenced values may be less generalizable between datasets.
Sex‐specific analysis of the rapid up‐titration of guideline‐directed medical therapies after a hospitalization for acute heart failure: Insights from the STRONG‐HF trial
Authors: Čerlinskaitė‐Bajorė Kamilė , Lam Carolyn S.P. , Sliwa Karen , Adamo Marianna , Ter Maaten Jozine M. , Léopold Valentine , Mebazaa Alexandre , Davison Beth , Edwards Christopher , Arrigo Mattia , Barros Marianela , Biegus Jan , Chioncel Ovidiu , Cohen‐Solal Alain , Damasceno Albertino , Diaz Rafael , Filippatos Gerasimos , Gayat Etienne , Kimmoun Antoine , Metra Marco , Novosadova Maria , Pagnesi Matteo , Pang Peter S. , Ponikowski Piotr , Saidu Hadiza , Takagi Koji , Tomasoni Daniela , Voors Adriaan A. , Cotter Gad , Čelutkienė Jelena 
Published: May 2023

AimsThe aim of this study was to evaluate efficacy and safety of rapid up‐titration of guideline‐directed medical therapies (GDMT) in men and women hospitalized for acute heart failure (AHF).Methods and resultsIn STRONG‐HF, AHF patients were randomized just prior to discharge to either usual care (UC) or a high‐intensity care (HIC) strategy of GDMT up‐titration. In these analyses, we compared the implementation, efficacy, and safety of the HIC strategy between men and women. In the randomized AHF population, 416/1078 (39%) were women. By day 90, a higher proportion of both sexes in the HIC group had been up‐titrated to full doses of GDMT compared to UC. Overall, there were no differences in the primary endpoint between the sexes. The primary endpoint, 180‐day heart failure readmission or death, occurred in 15.8% HIC women versus 23.5% women in the UC group (adjusted hazard ratio [HR] 0.67, 95% confidence interval [CI] 0.40–1.13) and in 14.9% HIC men versus 23.5% UC men (adjusted HR 0.57, 95% CI 0.38–0.88) (adjusted interaction p = 0.65). There was no significant treatment‐by‐sex interaction in quality‐of‐life improvement or in adverse events, including serious or fatal adverse events.ConclusionThe results of the current analyses suggest that a rapid up‐titration of GDMT immediately after an AHF hospitalization can and should be implemented similarly in men and women, as it results in reduction of 180‐day all‐cause death or heart failure readmission, quality‐of‐life improvement in both men and women with a similar safety profile.
Considering uncertainty in the collapse fragility of New Zealand buildings for risk‐targeted seismic design
Authors: Hulsey Anne M. , Horspool Nick , Gerstenberger Matthew C. , Sullivan Timothy J. , Elwood Kenneth J. 
Published: May 2023

AbstractThe risk‐targeted seismic design framework is used to set design intensities, based on achieving a target risk level (e.g., collapse or fatality risk) with respect to an assumed building collapse response. This paper assesses the distribution of fatality risk associated with the risk‐targeted design intensity, considering uncertainty in both the hazard and the variety of buildings that can satisfy the minimum design requirement. The randomness among buildings and their response is due to other design decisions (aleatory variability with respect to the design intensity) and can be represented by a distribution of fragility curves that quantify the collapse probabilities of as‐built, code‐conforming buildings. First, a single design intensity is calculated based on a “design fragility,” the mean hazard curve, and a risk target. The design fragility is taken as a conservative estimate from the distribution of collapse fragilities and the selected risk target approximates the risk associated with New Zealand's previous (non‐risk‐targeted) criteria for design intensities. Then the risk distribution is assessed, considering the aleatory variability in as‐built fragilities and the epistemic uncertainty in the new National Seismic Hazard Model. Accounting for variability in design decisions and uncertainty in the hazard model produces a risk distribution that more fully represents the potential risk associated with a given design intensity. This distribution can be compared to guidance on tolerable risk ranges, which suggest that risk can be variable among buildings but should fall within acceptable bounds. Sensitivity studies consider epistemic uncertainty in the assumed model for the distribution of as‐built fragilities. This inclusion of uncertainty to assess the risk distribution offers a powerful extension to the risk‐targeted framework. While this extension would not affect engineering practice (as the output is still a single design intensity), it allows building code developers to better understand and consider the risk implications associated with the selected design intensity.
Family forest landowner preferences for managing invasive species: Control methods, ecosystem services, and neighborhood effects
Authors: Atallah Shady S. , Huang Ju‐Chin , Leahy Jessica , Bennett Karen P. 
Published: May 2023

AbstractFamily forest landowners own and manage much of the world's forests, but we know little about their willingness to control biological invasions on their properties. Using a choice experiment, we find that landowners prefer mechanical methods and strongly oppose chemical methods when controlling the spread of an invasive shrub. Their choices are heterogeneously affected by ecosystem service outcomes resulting from control, namely timber production, trail recreation, and wildlife viewing. Landowners view their decision to control the invasive species on their land as a complement to the control by neighbors, offering further support for the areawide management of forest invasive species.