bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of ATM kinase rescues planarian regeneration after lethal radiation
Authors: Shiroor Divya A , Wang Kuang‐Tse , Sanketi Bhargav D , Tapper Justin K , Adler Carolyn E 
Published: March 2023

AbstractAs stem cells divide, they acquire mutations that can be passed on to daughter cells. To mitigate potentially deleterious outcomes, cells activate the DNA damage response (DDR) network, which governs several cellular outcomes following DNA damage, including repairing DNA or undergoing apoptosis. At the helm of the DDR are three PI3‐like kinases including Ataxia‐Telangiectasia Mutated (ATM). We report here that knockdown of ATM in planarian flatworms enables stem cells to withstand lethal doses of radiation which would otherwise induce cell death. In this context, stem cells circumvent apoptosis, replicate their DNA, and recover function using homologous recombination‐mediated DNA repair. Despite radiation exposure, atm knockdown animals survive long‐term and regenerate new tissues. These effects occur independently of ATM's canonical downstream effector p53. Together, our results demonstrate that in planarians, ATM promotes radiation‐induced apoptosis. This acute, ATM‐dependent apoptosis is a key determinant of long‐term animal survival. Our results suggest that inhibition of ATM in these organisms could, therefore, potentially favor cell survival after radiation without obvious effects on stem cell behavior.
Relapse of Graves' disease in Chinese children: a retrospective cohort study
Authors: Cui Yiyun , Chen Jinlong , Guo Rui , Yang Ruize , Chen Dandan , Gu Wei , Manyori Bigambo Francis , Wang Xu 
Published: March 2023

Background
Graves' disease (GD) among children has attracted wide attention. However, data on long-term follow-up are scarce, especially in China. This study aimed to investigate the prognosis after regular treatments of GD and to identify possible influencing factors.

Methods
A total of 204 newly diagnosed GD children in the Children's Hospital of Nanjing Medical University between 2013 and 2019 were included in this study. The cases involved were divided into remission group, relapse group, and continuing treatment group according to therapy outcomes. Relationships between prognosis and possible influencing factors in remission and relapse groups were analyzed.

Results
All 204 cases were treated with methimazole at presentation with GD. Due to severe complications, 4 (2.0%) cases changed medication to propylthiouracil. Of all the GD children included, 79 (38.7%) had remission, and 40 (50.6%) relapsed after remission. For each additional month before free thyroxine fell into the reference range with treatment, the risk of relapse increased 1.510 times (adjusted odds ratio (OR)=2.510, 95%CI: 1.561–4.034) compared to those in the remission group. On the contrary, the risk of relapse was reduced by 0.548 times for each additional hour of sleep duration per day (adjusted OR=0.452, 95%CI: 0.232–0.879).

Conclusion
GD children have a high relapse rate after remission, and most of them occur within 1 year. Thyroid function should be reexamined regularly after drug withdrawal. The response to medication and lifestyle of GD children may affect the prognosis.
The dogs of Roman Vindolanda, Part II: Time-stratigraphic occurrence, ethnographic comparisons, and biotype reconstruction
Authors: Bennett Deb , Timm Robert M. 
Published: March 2023

El fuerte-poblado romano de Vindolanda en el norte de Inglaterra fue ocupado desde el 50 al 415 A.D. y ha proporcionado una importante colección de restos bien conservados de perro, Canis familiaris. En este trabajo se contesta a las preguntas acerca de si los romanos criaron perros con el propósito de obtener morfotipos específicos o si aquellos perros se cruzaron libremente y de modo aleatorio (panmixis). También, si los perros fueron criados, si tal cría respondía a razones funcionales. Utilizando restos caninos bien contextualizados, respondemos estas preguntas incorporando análisis morfométricos, estadíos de desgaste dentario, patologías óseas, huellas impresas en cerámica (tejas) y registros documentales e iconográficos. Todas las cohortes de perro se encontraban aquí documentadas y no existen evidencias de que los perros fuesen consumidos. Las curvas de supervivencia son las clásicas con forma de U constatadas en poblaciones en equilibrio. Se constatan asímismo perros pequeños, medianos y grandes cuyas frecuencias variaron según el lugar de origen de las guarniciones que se sucedieron en el asentamiento. El cuidado de los canes lo confirma una perrera con forma de colmena y un individuo con heridas cicatrizadas. Los perros fueron usados para la caza y criados con tal fin. Integrando todas las fuentes de datos se han podido reconstruir los biotipos caninos de los romanos, infiriendo con ello su funcionalidad.
Structural brain differences related to compulsive sexual behavior disorder
Authors: Görts Per , Savard Josephine , Görts-Öberg Katarina , Dhejne Cecilia , Arver Stefan , Jokinen Jussi , Ingvar Martin , Abé Christoph 
Published: March 2023

AbstractBackground and aimsCompulsive sexual behavior disorder (CSBD) has been included as an impulse control disorder in the International Classification of Diseases (ICD-11). However, the neurobiological mechanisms underlying CSBD remain largely unknown, and given previous indications of addiction-like mechanisms at play, the aim of the present study was to investigate if CSBD is associated with structural brain differences in regions involved in reward processing.MethodsWe analyzed structural MRI data of 22 male CSBD patients (mean = 38.7 years, SD = 11.7) and 20 matched healthy controls (HC; mean = 37.6 years, SD = 8.5). Main outcome measures were regional cortical thickness and surface area. We also tested for case-control differences in subcortical structures and the effects of demographic and clinical variables, such as CSBD symptom severity, on neuroimaging outcomes. Moreover, we explored case-control differences in regions outside our hypothesis including white matter.ResultsCSBD patients had significantly lower cortical surface area in right posterior cingulate cortex than HC. We found negative correlations between right posterior cingulate area and CSBD symptoms scores. There were no group differences in subcortical volume.ConclusionsOur findings suggest that CSBD is associated with structural brain differences, which contributes to a better understanding of CSBD and encourages further clarifications of the neurobiological mechanisms underlying the disorder.
Predictive value of cardiovascular risk factors in the formation of cardiovascular and all-cause mortality: results of a 27-year cohort prospective study
Authors: Dolgalev I. V. , Ivanova A. Yu. , Karpov R. S. 
Published: March 2023

Aim. To study the prognostic significance of cardiovascular risk factors (RFs) in the formation of all-cause and cardiovascular mortality based on the results of a 27-year prospective cohort study of Tomsk population of both sexes aged 20-59 years.Material and methods. The object of study was random house-to-house sample of Tomsk population. In total, 1546 people (630 men and 916 women) aged 20-59 were examined. In 1988-1991, the prevalence of following cardiovascular RFs was studied: hypertension (HTN), overweight, smoking, alcohol consumption, hypercholesterolemia (HCE), low high-density lipoprotein cholesterol levels (hypo-HDL-emia), hypertriglyceridemia (HTG). All examination methods used were strictly standardized. To determine the RF, the criteria generally accepted in epidemiological studies were used. Over 27 years of follow-up, 330 deaths were recorded, including 142 due to cardiovascular disease.Results. In the multivariate Cox proportional hazard model, the following va­riables were studied: HTN, overweight, smoking, alcohol consumption, HCE, hypo-HDL-emia, HTG, coronary artery disease (CAD) (according to epi­demio­logical criteria), and age. The strongest predictor of of all-cause death was frequent alcohol use (relative risk (RR) 2,75). Smoking increased the risk of death by 2,72 times. Among former smokers, the risk of all-cause death was 1,9 times higher compared to non-smokers. HTN increases the death risk by 1,61 times. Each year of life lived increases the death risk by 1,06 times. The most significant risk factor for death from CVD was frequent alcohol consumption (RR 3,01). Smoking increases the cardiovascular death risk by 2,28 times. Among former smokers, the RR of cardiovascular death was 1,91. HTN increases the risk of cardiovascular mortality by 1,84 times compared with people with normal blood pressure. Each year of life lived increases the risk of cardiovascular death by 1,1 times. In multivariate analysis, overweight, HCE, hypo-HDL-emia, HTG did not have a significant independent effect on the all-cause and cardiovascular death risk.Conclusion. In a 27-year cohort prospective study, independent predictors of all-cause and cardiovascular mortality, along with hypertension and age, were lifestyle risk factors, such as smoking and frequent alcohol consumption.
Association of impaired myocardial flow reserve with risk factors for cardiovascular diseases in patients with nonobstructive coronary artery disease
Authors: Maltseva A. N. , Kop’eva K. V. , Mochula A. V. , Gulya M. O. , Dymbrylova O. N. , Grakova E. V. , Boshchenko A. A. , Zavadovsky K. V. 
Published: March 2023

Aim. To reveal the association between disorders of myocardial blood flow and reserve, according to dynamic single photon emission computed tomography (SPECT), with risk factors for cardiovascular diseases (CVD) in patients with nonobstructive coronary artery disease (CAD).Material and methods. The study included patients with suspected stable nonobstructive (<50%) CAD. Based on the survey data, anamnesis, out- and in-patient medical records, we analyzed main CVD risk factors. All patients underwent dynamic myocardial SPECT and analysis of blood lipid profile in vitro. Depending on myocardial flow reserve (MFR), two groups were formed: 1. With reduced MFR <2,0 (rMFR); 2. With normal MFR ≥2,0 (nMFR).Results. The study included 47 patients divided into 2 following groups: the rMFR group consisted of 24 patients (15 men, age 56,3±9,1 years), the nMFR group — 23 patients (13 men, age 58,4±10,7 years). There was no significant difference in prevalence of CVD risk factors in groups. However, dyslipidemia was detected more often in rMFR patients (p=0,053): 58% vs 30%, respectively. In patients with rMFR, there were significantly higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). Correlation analysis revealed significant negative inverse relationships between MFR values with TC (ρ=-0,36, p=0,01) and LDL-C (ρ=-0,38, p=0,009). According to univariate logistic regression, significant predictors of reduced MFR were TC (odds ratio (OR), 2,32; 95% confidence interval (CI), 1,17-4,59; p=0,01) and LDL-C (OR, 2,16; 95% CI, 1,04-4,51; p=0,04). According to a stepwise multivariate logistic regression analysis, only TC was an independent predictor of a decrease in MFR (OR, 2,32; 95% CI, 1,17-4,59; p=0,02).Conclusion. MFR, determined by dynamic SPECT, is associated with TC and LDL-C levels. TC level is an independent predictor of a decrease in MFR.
"<i>Festina lente</i>" — a multicenter study on the outcomes of carotid endarterectomy, depending on vessel suturing speed
Authors: Sautina M. S. , Sokolova A. S. , Butorina A. S. , Puchnina L. I. , Rylsky R. M. , Shmatov D. V. , Korotkikh A. V. , Lebedev O. V. , Artyukhov S. V. , Mukhtorov O. Sh. , Leader R. Yu. , Wang Sh. , Roshkovskaya L. V. , Khetagurov M. A. , Unguryan V. M. , Chernyavin M. P. , Bagdavadze G. Sh. , Palagin P. D. , Sirotkin A. A. , Kazantsev A. N. 
Published: March 2023

Aim. Analysis of inhospital and long-term outcomes of conventional carotid endarterectomy (CEA) depending on vessel suturing speed.Material and methods. The present prospective multicenter study for the period from March 1, 2017 to October 1, 2020 included 2366 patients who underwent conventional CEA with patch angioplasty. Depending on the time required to apply 1 stitch, 4 groups of patients were formed: group 1 (n=471; 19,9%) — 1 stitch per 2 seconds; group 2 (n=865; 36,5%) — 1 stitch per 3 seconds; group 3 (n=692; 29,2%) — 1 stitch per 4 seconds; group 4 (n=338; 14,3%) — 1 stitch per 5 seconds. The term "stitch" refers to two needle punctures. The follow-up postoperative period was 18,5±11,0 months.Results. There were no deaths and myocardial infarctions (MI) in the inhospital postoperative period. In group 1, anastomotic bleeding (n=93; 19,7%; p<0,0001) and stroke (n=3; 0,63%; p=0,02) due to internal carotid artery (ICA) thrombosis were more common. In the long-term follow-up period, there were no significant differences in mortality and MI rates. However, ICA restenosis requiring repeated CEA (n=37; 7,85%; p<0,0001) and related stroke/transient ischemic attack (n=13; 2,8%; p=0,0001) were more often diagnosed in 1 group of patients. According to Kaplan-Meier curves, restenosis was most often revealed 6 months after CEA in the general sample.Conclusion. 1. Vessel suturing at a speed of 1 stitch per 2 seconds is associated with an increased risk of intraoperative ICA thrombosis, bleeding along the anastomosis, stroke, as well as restenosis and stroke in the long-term follow-up period. 2. Vessel suturing at a speed of 1 stitch per 5 seconds is not accompanied by an increase in inhospital stroke rate, despite the maximum ICA occlusion time relative to other groups of patients. 3. Vessel suturing at a speed of 1 stitch per 3 or 4 seconds characterized by the lowest incidence of all complications at the inhospital and long-term stages of postoperative follow-up.
Clinical, Demographic and Echocardiographic Characteristics Of Pediatric Chest Deformities
Authors: DOĞAN Melih Timuçin , SERT Ahmet 
Published: March 2023

Objective: We aimed to retrospectively evaluate the clinical, demographic, clinical and echocardiographic findings of children diagnosed with chest deformity in the pediatric cardiology clinic.
Material and Method: This study enrolled children under the age of 18 years who were referred with chest deformity to our pediatric cardiology unit, over a period of six years (January 2017-December 2022).
Results: The mean age of the patients was 9.9 ± 5.2 years, median 11 years (0-18 years old). 89 patients with abnormal echocardiographic findings: 42 (9.56%) mitral valve prolapse, 18 (4.1%) atrial septal defect, 9 (2%) ventricular septal defect, 8 (1.82%) bicuspid without aortic valve stenosis aortic valve, 5 (1.1%) patent ductus arteriosus, 2 (0.45%) pulmonary stenosis, 2 (0.45%) great artery transposition, 2 (0.45%) hypertrophic cardiomyopathy, subaortic ridge 1 (% 0.27). Cardiac compression was present in 13.4% of the cases with pectus excavatum. 13(%3) patients were operated by a thoracic surgeon. Marfan Syndrome was diagnosed in 7 patients and Noonan Syndrome was diagnosed in 2 patients who applied to our clinic with chest deformity.
Conclusion: We suggest that echocardiographic examination in patients with chest deformity is important in the diagnosis of congenital heart diseases, early diagnosis and treatment of heart compression finding.
QUALIDADE MICROBIOLÓGICA DE ÁGUAS DE POÇOS ESCAVADOS NO INTERIOR DO ESTADO DE RONDÔNIA
Authors: Beltrão Rosa Niltra , Barcelos Valiatti Tiago , Ferreira Leite Pamela , Marques de Freitas Vinícius , De Oliveira Solla Sobral Fabiana , Faria Romão Natália 
Published: March 2023

A água tem significativa importância na vida de todos os seres vivos, sendo este um recurso essencial, contudo, se não estiver dentro dos parâmetros adequados, a mesma pode se tornar um veículo de transmissão de doenças. Diante disso, este estudo teve como objetivo avaliar a qualidade microbiológica de água de poços escavados de dois municípios do interior do estado de Rondônia. Para tanto, 12 amostras de água (seis de cada município), foram coletadas e submetidas a pesquisa de coliformes totais e coliformes termotolerantes por meio da técnica de Número Mais Provável (NMP). Os resultados obtidos após as análises mostraram que 83% das amostras estavam contaminadas por coliformes totais, enquanto que, o índice de contaminação por coliformes termotolerantes foi de 58%, estando essas amostras impróprias para o consumo humano. Conclui-se que maioria das amostras analisas representam risco para saúde humana, visto a contaminação apresentada por bactérias do grupo dos coliformes.
Congenital syphilis evaluated for syphilitic hepatitis - case series
Authors: Dantas Lopes Izailza Matos , Dantas Lopes Gabriel , Calazans Batista Jefferson Felipe , Santos Silva José Rodrigo , Prado Reis Francisco , Oliveira Lima Sonia 
Published: March 2023

Objective: To report case series evaluated for congenital syphilitic hepatitis. Method: Study conducted at Maternity Santa Isabel from December 2021 to May 2022. We evaluated newborns with congenital syphilis using data taken from the pregnant woman’s card, the child’s card, the anamnesis and exams performed in the follow-up consultations of these families. Complete medical records of infants who presented the criteria for the diagnosis of congenital syphilis of the Ministry of Health and the Center for Disease Transmission Control were included. Results: The review was 15 of which were selected that fit all the inclusion criteria. The babies were born with good vitality, term, one had low birth weight, six hepatomegaly, all treated with penicillin, nine had altered liver biochemical tests. At ultrasonography, Doppler was normal for all, one case of hepatosplenomegaly and one with splenomegaly. Two mothers who were diagnosed at the time of delivery had fewer than six consultations, their babies had neurosyphilis and presented developmental alertness. The child who had microcephaly and low birth weight also presented altered neurodevelopment. Of the pregnant women, three were over 30 years old, one was white, five had studied less than 8 years, thirteen were not working, family income of 1 minimum wage or less in twelve families. Eight were inadequately treated. Of the parents, eleven had studied less than 8 years and eleven were inadequately treated. Conclusion: The children with syphilis were born vigorous and had adequate treatment. Nine had altered hepatic biochemical exams, two had ultrasonographic alterations, however, without alterations in the Doppler. The children of untreated mothers had neurosyphilis and neurodevelopmental changes.
A MULHER E A LAVOURA CANAVIERA: UM ESTUDO SOBRE GÊNERO E A SUBJETIVIDADE FEMININA NA LAVOURA DE CANA-DE-AÇÚCAR NO CERRADO GOIANO NA REGIÃO DO VALE DO SÃO PATRÍCIO
Authors: Costa Dario Leopoldino da , Aparecida Leonel Lunas Divina , Aparecida Silva Adriana 
Published: March 2023

Este artigo está pautado na pesquisa bibliográfica, com base em algumas teorias de vários autores, sítios da rede mundial de computadores, artigos, livros, revistas, dissertações e teses que discutem o tema. Neste sentido, o objeto desta pesquisa está pautado na condição de gênero, em especial, com as transformações políticas de inclusão da mulher como parte integrante de direitos e deveres permeados pela igualdade entre homens e mulheres definidos na Constituição da República Federativa do Brasil de 1988 e demais legislações infraconstitucionais, partindo da premissa que o gênero é fator preponderante para estudo diante de tantas desigualdades vivenciadas pela mulher para o desenvolvimento do núcleo familiar atual. Conclui-se que o trabalho feminino no agronegócio da cana-de-açúcar, em especial no Cerrado goiano na Região do Vale do São Patrício, mudou o panorama vigente, o qual era tido como absolutamente masculino.
Palavras-chave: Gênero. Desigualdades. Mulher. Homem. Políticas.
Актуальные подходы к определению феномена «научная репутация» современного исследователя
Authors: Лыжин А.И. , Коновалов А.А. 
Published: March 2023

Предпринята попытка привлечь внимание научного сообщества к обсуждению феномена «репутация современного исследователя». На основе анализа различных точек зрения отечественных и зарубежных ученых, органов исполнительной власти, регулирующих деятельность системы образования, сформулировано определение данного понятия для его дальнейшего использования в процессе управления научно-исследовательской деятельностью. Определены факторы, влияющие на формирование научной репутации, предложена система государственных и локальных мер по повышению статуса исследователя в Российской Федерации.
An attempt was made to draw the attention of the scientifi c community to the discussion of the phenomenon of “the reputation of a modern researcher”. Based on the analysis of various points of view of domestic and foreign scientists, executive authorities that regulate the activities of the education system, the defi nition of this concept is formulated for its further use in the process of managing research activities. The factors infl uencing the formation of a scientifi c reputation are determined, a system of state and local measures to improve the status of a researcher in the Russian Federation is proposed.
Актуальные задачи развития и оценки сформированности субъектной позиции будущего врача в медицинском вузе
Authors: Гаранина Р.М. 
Published: March 2023

Рассматриваются вопросы значимости процесса образования, предполагающего активизацию внутренних механизмов мотивации студентов к обучению. Приводится авторское определение субъектной активности студента в учебно-профессиональной деятельности. Посредством эмпирического изучения личностных качеств студентов, реально проявляемых в образовательном пространстве вуза, выявлены и обоснованы три уровня развития субъектной активности и мотивации, тесно связанные с уровнями сформированности субъектной позиции обучающегося. Изучена динамика изменения личностных показателей: уровень мотивации и сформированности субъектной позиции. Представлены данные экспериментального исследования по определению уровней сформированности субъектной позиции студентов медицинского вуза на основе диагностики личности на наличие субъектной активности и мотивации к успешной деятельности на этапе обучения в вузе.
The issues of the signifi cance of the educational process, which involves the activation of internal mechanisms of students’ motivation for learning, are considered. The author’s defi nition of the student’s subjective activity in educational and professional activities is given. Through an empirical study of the personal qualities of students that are actually manifested in the educational space of the university, three levels of development of subjective activity and motivation are identifi ed and substantiated, closely related to the levels of formation of the student’s subjective position. The dynamics of changes in personal indicators has been studied: the level of motivation and the formation of the subjective position. The data of an experimental study to determine the levels of formation of the subject position of students of a medical university based on personality diagnostics for the presence of subjective activity and motivation for successful activity at the stage of training at a university are presented.