bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential roles of heparanase in cancer therapy: Current trends and future direction
Authors: Yang Yiyuan , Yuan Fengyan , Zhou Huiqin , Quan Jing , Liu Chongyang , Wang Yi , Xiao Fen , Liu Qiao , Liu Jie , Zhang Yujing , Yu Xing 
Published: March 2023

AbstractHeparanase (HPSE; heparanase‐1) is an endo‐β‐glucuronidase capable of degrading the carbohydrate moiety of heparan sulfate proteoglycans, thus modulating and facilitating the remodeling of the extracellular matrix and basement membrane. HPSE activity is strongly associated with major human pathological complications, including but not limited to tumor progress and angiogenesis. Several lines of literature have shown that overexpression of HPSE leads to enhanced tumor growth and metastatic transmission, as well as poor prognosis. Gene silencing of HPSE or treatment of tumor with compounds that block HPSE activity are shown to remarkably attenuate tumor progression. Therefore, targeting HPSE is considered as a potential therapeutical strategy for the treatment of cancer. Intriguingly, recent findings disclose that heparanase‐2 (HPSE‐2), a close homolog of HPSE but lacking enzymatic activity, can also regulate antitumor mechanisms. Given the pleiotropic roles of HPSE, further investigation is in demand to determine the precise mechanism of regulating action of HPSE in different cancer settings. In this review, we first summarize the current understanding of HPSE, such as its structure, subcellular localization, and tissue distribution. Furthermore, we systematically review the pro‐ and antitumorigenic roles and mechanisms of HPSE in cancer progress. In addition, we delineate HPSE inhibitors that have entered clinical trials and their therapeutic potential.
How transparent are aid agencies to their citizens? Introducing the Citizen Aid Transparency Dataset
Authors: Reinsberg Bernhard , Swedlund Haley 
Published: March 2023

AbstractExisting measures of aid transparency overwhelmingly focus on how much information donor agencies are willing to share with the international donor community, overlooking that transparency is about increasing citizens' access to information in order to improve government accountability. In this article, we present the Citizen Aid Transparency Dataset (CATD). Using factor and correlation analysis, we show that the CATD captures a different dimension of transparency than existing transparency measures. We also show that aid agency transparency varies both within and between donor countries and that there are important quality differences between agencies in the timeliness, breadth, depth and accessibility of the data provided.
Tax incentives, private investment and employment: Evidence from an Ecuadorian reform
Authors: Camino‐Mogro Segundo 
Published: March 2023

AbstractThis paper estimates the effect of the Organic Law for Productive Development, Attraction of Investments, Generation of Employment and Stability and Fiscal Balance on new investment and employment applied in August 2018 in Ecuador. Using event study designs and difference‐in‐ differences models, I find that the policy implementation does not have an effect on the attraction of new investments or the creation of new employment for prioritised sectors compared to non‐prioritised sectors. This matters from a policy perspective in a country with few private investments and a high share of people out of formal employment.
The influence of matrix concentration and solvent composition on the results of MALDI MSI, with the aid of wet‐interface matrix deposition
Authors: Mielczarek Przemyslaw , Suder Piotr , Kotsan Igor , Bodzon‐Kulakowska Anna 
Published: March 2023

AbstractImaging mass spectrometry is a powerful technique for the molecular analysis of tissue sections. As in many analytical methods, sample preparation is one of the main and most important steps to obtain results of good quality. Usually, the matrix concentration and solvent composition in different studies are taken for granted without any further consideration. In our studies, we aimed to find how matrix concentration and a type of solvent influence the signal. Moreover, we also aimed to find the relationship between these parameters, how they influence the spectra, and how they influence obtained ion maps. In our experiments, we used SunCollect®, which is a commercially available wet‐interface system for matrix deposition. We decided to choose two matrix concentrations (2,5‐dihydroxybenzoic acid [DHB]: 15 and 25 mg/mL; 9‐aminoacridine [9AA]: 7 and 5 mg/mL) and two different water solutions of solvents in two different percentages for the matrices (DHB: 50% and 70% of methanol [MeOH] and acetonitrile [ACN]; 9AA 70% and 50% of ethanol [EtOH] and MeOH). In the end, the influence of these parameters on obtained spectra and ion maps was assessed.
Topical nonsteroidal anti‐inflammatory drugs for management of osteoarthritis pain: A consensus recommendation
Authors: Lee Joon‐Kiong , Abbas Azlina A. , Cheah Tien‐Eang , Simanjuntak Ruslan Nazaruddin , Sockalingam Sargunan , Roohi Sharifah 
Published: March 2023

AbstractOsteoarthritis (OA) contributes to significant medical and socioeconomic burden in many populations. Its prevalence is expected to rise continuously owing to the combined effects of aging and increase in risk factors, including obesity, physical inactivity, and joint injuries. Pain is a hallmark presentation of OA. Topical nonsteroidal anti‐inflammatory drugs (NSAIDs) are recommended by many international guidelines as an early treatment option of the management of osteoarthritic pain. However, the use of topical NSAIDs remains low in Malaysia and appears not to be a preferred agent in managing OA pain by prescribers. There is also limited guidance from local medical bodies on the use of topical NSAIDs to manage OA pain. This consensus recommendation is intended to serve as a practical guide for healthcare practitioners on the use of topical NSAIDs in the management of OA pain. Eight statements and recommendations were finalized covering the areas of OA burden, topical NSAIDs formulations, safety and efficacy of topical NSAIDs, and patient education. Robust evidence is available to support the efficacy and safety of topical NSAIDs, with its benefits further strengthened by ease of use and access. Taking these into consideration, we recommend that healthcare practitioners advocate for the early use of topical NSAIDs over oral NSAIDs for mild‐to‐moderate OA pain, while engaging in a shared decision‐making process with patients for optimal clinical outcomes.
Minced muscle autografting improves bone healing but not muscle function in a porcine composite injury model
Authors: McKinley Todd O. , Natoli Roman N. , Janakiram Naveena B. , Warden Stuart J. , Fuchs Robyn K. , Gunderson Zachary , Diggins Nichlaus , Sun Seungyup , Kolettis George , Goldman Stephen M. , Dearth Christopher L. , Mendenhall Stephen , Staut Caio , Kacena Melissa A. , Corona Benjamin T. 
Published: March 2023

AbstractComposite tissue injuries (CTIs) in extremities include segmental bone defects (SBDs) and volumetric muscle loss. The objective of this study was to determine if skeletal muscle autografting with minced muscle grafts (MMGs) could improve healing in an SBD and improve muscle function in a porcine CTI model that includes an SBD and adjacent volumetric muscle loss injury. Adult Yucatan Minipigs were stratified into three groups including specimens with an isolated SBD, an SBD with volumetric muscle loss (CTI), and an SBD with volumetric muscle loss treated with MMG (CTI + MMG). Bone healing was quantified with serial x‐rays and postmortem computed tomography scanning. Muscle function was quantified with a custom in vivo force transducer. Muscle tissue content was determined by biochemical analyses and histology. Anterior cortex‐modified Radiographic Union Score for Tibia fractures (mRUSTs) decreased from 2.7 to 1.9 (p = 0.003) in CTI versus SBD animals. MMG improved anterior mRUST scores to 2.5 in CTI + MMG specimens (p = 0.030 compared to CTI specimens) and overall mRUST scores increased from 9.4 in CTI specimens to 11.1 in CTI + MMG specimens (p = 0.049). Residual strength deficits at euthanasia were 42% in SBD (p < 0.001), 44% in CTI (p < 0.001), and 48% in CTI + MMG (p < 0.001) compared to preoperative values. There were no differences in strength deficits between the three groups. Biochemical and histologic analyses demonstrated scattered differences between the three groups compared to contralateral muscle. MMG improved bone healing. However, the primary cause of muscle dysfunction and biochemical changes was the presence of an SBD. Clinical significance: Early mitigation of SBDs may be necessary to prevent muscle damage and weakness in patients sustaining composite extremity trauma.
Preoperative radiographic findings associated with postoperative spinopelvic risk factors for instability following total hip arthroplasty
Authors: Mills Emily S. , Bouz Gabriel J. , Kang Hyunwoo P. , Chung Brian C. , Wang Jennifer C. , Tezuka Taro , Dorr Lawrence D. , Heckmann Nathanael D. 
Published: March 2023

AbstractPostoperative spinopelvic changes are associated with increased dislocation risk following total hip arthroplasty (THA). The aim of this study was to identify preoperative patient and radiographic factors associated with high‐risk postoperative spinopelvic parameters. A retrospective review of consecutive THA patients who received preoperative and postoperative sitting and standing lateral lumbar spine‐hip radiographs with minimum radiographic and clinical follow‐up of 10 months was performed. Patient demographics were recorded and preoperative standing and sitting sacral slope (SS), anteinclination, pelvic femoral angle (PFA), and combined sagittal index (CSI) were measured. High‐risk patients were defined by decreased spinopelvic motion (∆SS from sitting to standing of >10°), increased hip motion (∆PFA from sitting to standing of >10°), or decreased CSI of >10° at final follow‐up compared with preoperative measurements. Univariate and multivariate regression analyses were used to identify preoperative demographic and radiographic factors associated with these high‐risk categories. One hundred and fifty‐three patients were included with an average age of 62 years, average body mass index of 27.8 kg/m2, and average follow‐up of 16.2 months. At 1‐year follow‐up, 43 (28.1%) patients demonstrated a decreased ∆SS > 10° and 67 (43.7%) patients demonstrated an increased ∆PFA > 10° compared with preoperative values. Sitting CSI decreased by >10° in 17 (11.1%) patients. Preoperative increased sitting PFA (adjusted odds ratio [aOR] 1.057, p < 0.001) and decreased preoperative hip motion (∆PFA) were associated with decreased sitting CSI of >10° at 10‐month follow‐up. Increased spinopelvic motion (∆SS) and decreased hip motion (∆PFA) preoperatively are associated with postoperative radiographic changes that be associated with increased dislocation risk.
Esters of Cinnamic Acid as Green Plasticizers for Polylactide Formulations with Improved Ductility
Authors: Barandiaran Alejandro , Gomez‐Caturla Jaume , Ivorra‐Martinez Juan , Lascano Diego , Selles Miguel Angel , Moreno Virginia , Fenollar Octavio 
Published: March 2023

AbstractThis study demonstrates the potential of different cinnamate esters, namely methyl trans‐cinnamate (MC), isobutyl cinnamate (IBC), allyl cinnamate (AC), and ethyl cinnamate (EC), as environmentally friendly plasticizers for polylactide (PLA). Plasticized PLA formulations with a constant nominal wt% of 20 of each plasticizer are compounded in a twin‐screw co‐rotating extruder and subsequently processed by injection molding. The results show exceptional plasticization efficiency of AC with an increase in elongation at break from 3.9% (neat PLA), up to 339.4% and a remarkable increase in impact strength, thus showing great potential to overcome the main drawback related to PLA intrinsic brittleness. The incorporation of cinnamates in a PLA matrix leads to a decrease in Tg from 61.7 °C down to 36.1 °C for the plasticized PLA formulation containing 20 wt% AC. Thermogravimetry analysis reveals that a slight plasticizer loss occurs during processing, as it happens with other monomeric plasticizers, but this phenomenon does not limit their plasticization efficiency. Therefore, the results obtained in this study confirm the suitability of a new family of organic compounds derived from the esterification of cinnamic acid as green plasticizers for PLA with improved toughness, with comparable, or even superior, ductile properties of typical plasticizers for PLA.
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development
Authors: He Xuemei , He Cai , Hong Weiqi , Yang Jingyun , Wei Xiawei 
Published: March 2023

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic can hardly end with the emergence of different variants over time. In the past 2 years, several variants of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), such as the Delta and Omicron variants, have emerged with higher transmissibility, immune evasion and drug resistance, leading to higher morbidity and mortality in the population. The prevalent variants of concern (VOCs) share several mutations on the spike that can affect virus characteristics, including transmissibility, antigenicity, and immune evasion. Increasing evidence has demonstrated that the neutralization capacity of sera from COVID‐19 convalescent or vaccinated individuals is decreased against SARS‐CoV‐2 variants. Moreover, the vaccine effectiveness of current COVID‐19 vaccines against SARS‐CoV‐2 VOCs is not as high as that against wild‐type SARS‐CoV‐2. Therefore, more attention might be paid to how the mutations impact vaccine effectiveness. In this review, we summarized the current studies on the mutations of the SARS‐CoV‐2 spike, particularly of the receptor binding domain, to elaborate on how the mutations impact the infectivity, transmissibility and immune evasion of the virus. The effects of mutations in the SARS‐CoV‐2 spike on the current therapeutics were highlighted, and potential strategies for future vaccine development were suggested.
Leveraging the ATP‐P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications
Authors: Yin Yaling , Wei Linyu , Caseley Emily A. , Lopez‐Charcas Osbaldo , Wei Yingjuan , Li Dongliang , Muench Steve P. , Roger Sebastian , Wang Lu , Jiang Lin‐Hua 
Published: March 2023

AbstractThe P2X7 receptor is an exceptional member of the P2X purinergic receptor family, with its activation requiring high concentrations of extracellular adenosine 5ʹ‐triphosphate (ATP) that are often associated with tissue damage and inflammation. In the central nervous system (CNS), it is highly expressed in glial cells, particularly in microglia. In this review, we discuss the role and mechanisms of the P2X7 receptor in mediating neuroinflammation and other pathogenic events in a variety of traumatic CNS damage conditions, which lead to loss of neurological and cognitive functions. We raise the perspective on the steady progress in developing CNS‐penetrant P2X7 receptor‐specific antagonists that leverage the ATP‐P2X7 receptor signaling axis as a potential therapeutic strategy to alleviate traumatic CNS damage and related complications.
High isolation and high power of 0.13 µm CMOS SPDT switch using deep‐N‐well transistors and floating‐body technique in K‐band
Authors: Wang Zongxiang , Cheng Guoxiao , Kang Wei , Li Zekun , Chen Jixin 
Published: March 2023

AbstractA K‐band high isolation single‐pole double‐throw (SPDT) switch using a 0.13 µm CMOS process is presented. Two on‐state resistors of shunt Deep‐N‐Well (DNW) transistors are used to improve isolation. The floating‐body technique is utilized to enhance the power‐handling capability. The off‐state capacitors of two DNW transistors are employed to construct an impedance‐matching network. The switch achieves a measured insertion loss of 3.0–3.2 dB and an isolation of better than 35 dB from 17 to 27 GHz. A measured input 1 dB compression power (IP1dB) of 11.8 dBm is obtained at 24 GHz. The chip size of the proposed switch is 0.52 × 0.66 mm2with a core area of only 0.33 × 0.27 mm2.
Hyponatremia and lower normal serum sodium levels are associated with an increased risk of all‐cause death in heart failure patients
Authors: Zhao Lang , Zhao Xuemei , Zhuang Xiaofeng , Zhai Mei , Wang Yunhong , Huang Yan , Zhou Qiong , Tian Pengchao , Liang Lin , Huang Boping , Huang Liyan , Feng Jiayu , Zhang Yuhui , Zhang Jian 
Published: March 2023

AbstractAimTo explore the relationship between the serum sodium level on admission and all‐cause mortality in HF patients.DesignA single‐center retrospective cohort study.MethodsPatients hospitalized with HF at the Heart Failure Center, Fuwai Hospital, from November 2008 to November 2018 were enrolled.ResultsA total of 3649 patients were included, and the mean sodium level was 137.19 ± 4.36 mmol/L, with a range from 115.6 to 160.9 mmol/L. During a median follow‐up of 1101 days, mortality occurred in 1413 (38.7%) hospital survivors. After adjustment for age, sex, and other potential confounders, patients with sodium levels <135 mmol/L (hazard ratio [HR]: 1.67; 95% confidence interval [CI]: 1.29–2.16) and 135–137 mmol/L (HR: 1.34; 95% CI: 1.01–1.78) had an increased risk of all‐cause mortality compared to those with sodium levels of 139–141 mmol/L.
Associations of dual use of tobacco cigarettes and e‐cigarettes, sleep duration, physical activity and depressive symptoms among middle‐aged and older Korean adults
Authors: You Mi‐Ae , Choi JiYeon , Son Youn‐Jung 
Published: March 2023

AbstractAimThere is limited evidence of the association between dual tobacco–e‐cigarette use and health‐related variables in Korea. Thus, this study aimed to investigate the associations between types of cigarette smoking, sleep duration, physical activity and depressive symptoms among Korean adults.DesignA cross‐sectional study design using the 2019 Korean Community Health Survey.MethodsThe study subjects consisted of 179,004 adults older than 40 years from a total of 229,099 individuals. Self‐reported general characteristics, smoking history, sleep duration, physical activity and depressive symptoms were analysed.ResultsIn multinomial logistic regression, dual users of tobacco cigarettes and e‐cigarettes were more likely to have sleep duration of less than 7 h per day and to report both mild and moderate‐to‐severe depressive symptoms than non‐smokers. Single use of either cigarettes or e‐cigarettes increased the risk of short sleep duration and moderate‐to‐severe depressive symptoms.
Harms Reporting in Systematic Reviews of the Microvascular Free Flap in Head and Neck Reconstruction
Authors: Wilson Andrew D. , Ernst Zachary , Wise Audrey , Flores Holly , Garrett Morgan , Torgerson Trevor , Hamilton Tom , Vassar Matt 
Published: March 2023

AbstractObjectiveTo evaluate harms reporting in systematic reviews (SRs) of microvascular free flap (MFF) in head and neck reconstruction.Data SourcesThis cross‐sectional analysis included searches from the following major databases from 2012 to June 1, 2022: MEDLINE (Pubmed and Ovid), Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews.Review MethodsIn a masked duplicate manner, screening was performed using Rayyan, and data were extracted using a pilot‐tested Google form. A MeaSurement Tool to Assess systematic Reviews‐2 (AMSTAR‐2) was used to appraise the methodological quality of reviews and the corrected covered area was calculated to detect primary study overlap across all reviews. Reviews were then grouped in pairs of 2, called dyads, and the corrected covered area was calculated again for each individual dyad. Dyads with high overlap (≥50%) were further investigated for the accuracy of harms reporting.ResultsOur initial search yielded 268 records, with 50 SRs meeting the inclusion criteria. A total of 46 (92%) of the included reviews demonstrated 50% or more adherence to the items assessed in our harms checklist. Our corrected covered area tool revealed 0.6% primary study overlap across all reviews, and 1 dyad with high overlap (≥50%). No statistically significant relationship was observed between the completeness of harms reporting and reviews listing harms as a primary outcome, reviews reporting adherence to Preferred Reporting Items of Systematic Reviews and Meta‐Analyses, or a review's AMSTAR rating.ConclusionThis study identifies how harms reporting in SRs of MFF reconstruction of the head and neck can be improved and provides suggestions with the potential to mitigate the paucity in current literature.
The role of alkoxysilanes in propylene polymerization catalysis. A study of model Ti(Oi‐C3H7)4‐Al(C2H5)2Cl/Mg(C4H9)2 catalyst system
Authors: Kissin Yury V , Rishina Laura A , Lalayan Svetlana S , Krasheninnikov Vadim G 
Published: March 2023

AbstractThe article describes the modifying effect of methylcyclohexyldimethoxysilane (CH3)(cyclo‐C6H11)Si(OCH3)2 in propylene polymerization reactions with a pseudo‐homogeneous catalyst system: Ti(Oi‐C3H7)4‐Al(C2H5)2Cl/Mg(C4H9)2. This catalyst system is a convenient model for the analysis of modifier effects (effects of ‘external donors’) in supported Ziegler–Natta polymerization catalysts of the fourth generation. A combination of chromatographic, spectroscopic and calorimetric data for crystalline and amorphous fractions of polypropylene prepared in the presence of the silane shows that it has a dual modification effect: (i) the silane is a potent poison of stereo‐aspecific active centers in the catalyst (the centers producing amorphous polypropylene fraction) and (ii) silane molecules coordinate at isospecific centers in the catalyst and changes their nature: the centers produce isotactic polypropylene of higher molecular weight and a higher isotacticity level. © 2023 Society of Industrial Chemistry.
‘FLLA09015‐U1’: A broadly adapted dual‐purpose oat cultivar for southern USA
Authors: Babar Md Ali , Harrison Stephen A. , Blount Ann , Barnett Ronald D. , Johnson Jerry , Mergoum Mohamed , Mailhot Daniel J , Murphy J. Paul , Mason Richard E. , Ibrahim Amir , Sutton Russell , Simoneaux Bryan , Boyles Richard , Stancil Brad , Marshall David , Fountain Myron , Klos Kathy Esvelt , Khan Naeem , Wallau Marcelo , Jordan Henry G. 
Published: March 2023

Abstract‘FLLA09015‐U1’ (Reg. no. CV‐387, PI 699117) is a new facultative oat (Avena sativa L.) cultivar that was co‐developed by the University of Florida and Louisiana State University Agricultural Center and was released in 2019. This line was derived from a single cross of FL0210‐J1/MN06203. FLLA09015‐U1 has considerable potential for grain and forage yield and for conservation tillage purposes in the southern United States. Exclusive marketing rights for FLLA09015‐U1 has been granted to JoMar Seeds and is currently commercialized under the name of Juggernaut. FLLA09015‐U1 was developed using selected bulk breeding method and was selected as an F5:6 head row. The line was evaluated in advanced, regional, and state grain and forage yield trials from 2015 to 2021. FLLA09015‐U1 was observed to be uniform and stable across environments in the southern United States from 2015 to present. The line possesses a semi‐prostrate growth habit and has large leaves that are dark green in color. It is a mid‐maturing, medium to mid‐tall height with excellent grain yield and good forage yield and test weight. It has excellent crown rust resistance and very good resistance to Barley yellow dwarf virus and stem rust and demonstrated moderate lodging resistance. It has performed very well in both grain and forage trials. FLLA09015‐U1 has broad environmental adaptation and has performed well in Louisiana, Florida, Georgia, Texas, Alabama, and South Carolina. We consider FLLA09015‐U1 to be a good dual‐purpose type of oat because of its high grain yield potential and vigorous growth and high tillering capacity.