bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder
Authors: Wong Brendan L. , Kim Bohye , Singh Manpreet K. , Kim Jane P. , McRae-Clark Aimee L. , Sahlem Gregory L. 
Published: January 2025

AbstractBackgroundStudies across multiple addictions have suggested that repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (L-DLPFC) reduces cue-induced-craving (CIC), however there are no studies in treatment seeking participants with cannabis use disorder (CUD). In this secondary analysis of a previously completed trial, we explore whether a multi-session course of rTMS reduces CIC in CUD.MethodsSeventy-one participants with ≥moderate CUD (age=30.2±9.9;37.5% female) were randomized to twenty sessions of active or sham rTMS applied to the left DLPFC (20-sessions, Beam-F3; 10Hz) in a two-site, double-blind, sham-controlled, phase-2 trial where they also received motivational enhancement therapy. Participants rated their craving for cannabis via the short-form of the marijuana craving questionnaire (MCQ-SF) before and after a neutral and cannabis-cue presentation. Participants underwent assessment before (immediate-pre), after (immediate-post), and two-, and four-weeks following the course of rTMS.ResultsThe MCQ-SF scores increased following the presentation of cannabis cues relative to neutral cues at the immediate-pre timepoint in both treatment groups (p<0.0001). Following study treatment, the percent increase in MCQ-SF following cues diverged between the active and sham groups with significantly reduced CIC in the active group at the two-week post time-point (5.8±7.1% sham group, 0.91±4.1% active group;p=0.02). Between-group effect sizes (Cohen’s d) were 0.24, 0.89, and 0.67 at the immediate-post, 2-week, and 4-week follow-up periods respectively.ConclusionsL-DLPFC applied rTMS may reduce CIC in treatment seeking participants with CUD.HighlightsCraving may be separable into tonic and phasic constructsDLPFC applied rTMS did not effect tonic craving in a recent treatment trial for CUDData from that same trial suggests that DLPFC applied rTMS may have reduced phasic craving
Biflavonoids can potentially inhibit amyloid beta internalization to mitigate its cytotoxic events
Authors: Haque Md. Aminul , Hossain Md. Selim , Park Il Seon 
Published: January 2025

AbstractAmyloid-β-42 (Aβ) peptides are key contributors to Alzheimer’s disease (AD), with recent studies highlighting a strong link between Aβ toxicity and its internalization into cells. Targeting the internalization of Aβ using naturally occurring small molecules could represent a promising strategy for developing therapeutic interventions. In this study, we investigated the effects of biflavonoids on inhibiting the internalization of Aβ and its impact on cellular processes that lead to cell death. Various biochemical techniques were employed to assess the ability of biflavonoids to prevent Aβ42 uptake and to elucidate the underlying mechanisms of their inhibitory action. Our findings revealed that biflavonoids exert a dose-dependent inhibitory effect on Aβ toxicity. The cytoprotective effects of biflavonoids were primarily attributed to their ability to block Aβ internalization, as confirmed through confocal microscopy and validated by western blot analysis. By preventing Aβ entry into cells, biflavonoids also inhibited Aβ-induced lamin fragmentation and caspase activation, both of which are critical steps in Aβ-mediated cytotoxicity. Furthermore, we explored the influence of biflavonoids on the aggregation process of Aβ, including fibril, oligomer, and β-sheet formation, and found that biflavonoids effectively inhibited these conformational changes. Based on these results, we propose that biflavonoids suppress Aβ cytotoxicity by blocking its conformational changes and subsequent internalization, thereby highlighting their potential as anti-amyloidogenic therapeutic agents.
The evolution of mutation rates in the light of development and cell-lineage selection
Authors: Majic Paco , Srivastava Malvika , Crocker Justin 
Published: January 2025

AbstractMutation rates drive the pace and potential of evolutionary change. However, to better understand the evolutionary implications of mutation rates, there is a need to uncover the causes of their diversfification. In multicellular organisms, all mutations first arise in a single cell in a developmental context. Whether a mutation enters a population’s gene pool can therefore depend on developmental events that affect the likelihood of mutant cell lineages of producing gametes. For this reason, the evolution of mutation rates in populations is governed not only by changes in the rates at which mutations occur at the molecular level, but also by changes in developmental features of organisms and how mutations impact cellular fitness during development. We present a theoretical framework that, supported by empirical data from mammals and experiments on the fruit fly, demonstrate how generational mutation rates can be shaped by changes in developmental parameters and intraorganismal selective processes even when molecular mutation rates are presumed constant. Our model highlights how the diversity of mutation rates observed across animals may be the byproduct of organismal development rather than the result of direct selection against mutator alleles. As such, development not only introduces phenotypic biases, it also shapes the rates and trajectories of genetic diversity and is thus at the core of evolutionary theory.
Environmental factors drive bacterial degradation of gastrointestinal mucus
Authors: Arias Sandra L. , van Wijngaarden Ellen W. , Balint Diana , Jones Joshua , Crawford Carl C. , Shukla Parul J. , Silberstein Meredith , Brito Ilana L. 
Published: January 2025

ABSTRACTThe mucus layer lining the gastrointestinal tract is essential for gut health, providing a protective barrier against pathogens while maintaining symbiosis with the microbiome. Its disruption is a hallmark of gastrointestinal diseases like ulcerative colitis. While glycan foraging by gut bacteria is thought to initiate mucus disruption, its impact on mucus structural properties remains poorly understood, largely due to the lack of physiologically relevant models. To address this gap, we developed a method to collect human-cell-derived mucus that closely mimics the mechanical properties of human colonic mucus. Using this system, we investigated mucus utilization and degradation by a panel of commensal bacteria with distinct metabolic profiles. Glycan utilization by species such asBacteroides thetaiotaomicronandBacteroides fragilisshowed no correlation with changes in mucus rheology. Instead, secreted proteases were identified as the primary driver of mucus degradation. Protease activity byB. fragilisandBifidobacterium longumwas influenced by nutrient availability, whereas inEnterococcus faecalis,it was additionally affected by oxygen exposure. E. faecalisalso adapted to oxidative stress by enhancing carbohydrate metabolism and upregulating several virulence genes. Together, our findings reveal that bacterial mucus degradation is context-dependent and shaped by environmental factors. This study provides key insights into the mechanisms underlying mucus degradation and underscores the value of human cell-derived mucus models for understanding bacteria-mucus interactions in health and disease.
Experience-dependent reorganization of inhibitory neuron synaptic connectivity
Authors: Fink Andrew J.P. , Muscinelli Samuel P. , Wang Shuqi , Hogan Marcus I. , English Daniel F. , Axel Richard , Litwin-Kumar Ashok , Schoonover Carl E. 
Published: January 2025

SummaryOrganisms continually tune their perceptual systems to the features they encounter in their environment1–3. We have studied how ongoing experience reorganizes the synaptic connectivity of neurons in the olfactory (piriform) cortex of the mouse. We developed an approach to measure synaptic connectivityin vivo, training a deep convolutional network to reliably identify monosynaptic connections from the spike-time cross-correlograms of 4.4 million single-unit pairs. This revealed that excitatory piriform neurons with similar odor tuning are more likely to be connected. We asked whether experience enhances this like-to-like connectivity but found that it was unaffected by odor exposure. Experience did, however, alter the logic of interneuron connectivity. Following repeated encounters with a set of odorants, inhibitory neurons that responded differentially to these stimuli exhibited a high degree of both incoming and outgoing synaptic connections within the cortical network. This reorganization depended only on the odor tuning of the inhibitory interneuron and not on the tuning of its pre- or postsynaptic partners. A computational model of this reorganized connectivity predicts that it increases the dimensionality of the entire network’s responses to familiar stimuli, thereby enhancing their discriminability. We confirmed that this network-level property is present in physiological measurements, which showed increased dimensionality and separability of the evoked responses to familiar versus novel odorants. Thus, a simple, non-Hebbian reorganization of interneuron connectivity may selectively enhance an organism’s discrimination of the features of its environment.
Combining Clinical Embeddings with Multi-Omic Features for Improved Patient Classification and Interpretability in Parkinson’s Disease
Authors: Lee Chaeeun , Ryan Barry , Marioni Riccardo E. , Minervini Pasquale , Simpson T. Ian 
Published: January 2025

AbstractThis study demonstrates the integration of Large Language Model (LLM)-derived clinical text embeddings from the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) questionnaire with molecular genomics data to enhance patient classification and interpretability in Parkinson’s disease (PD). By combining genomic modalities encoded using an interpretable biological architecture with a patient similarity network constructed from clinical text embeddings, our approach leverages both clinical and genomic information to provide a robust, interpretable model for disease classification and molecular insights. We benchmarked our approach using the baseline time point from the Parkinson’s Progression Markers Initiative (PPMI) dataset, identifying the Llama-3.2-1B text embedding model on Part III of the MDS-UPDRS as most informative. We further validated the framework at years 1, 2, 3 post baseline, achieving significance in identifying PD associated genes from a random null set by year 2 and replicating the association of MAPK with PD in a heterogenous cohort. Our findings demonstrate that the combination of clinical text embeddings with genomic features is critical for classification and interpretation. LLM text embeddings not only increase classification accuracy but also enable interpretable genomic analysis, revealing molecular signatures associated with PD progression.
Intersectional precarity in academia: a systematic literature review
Authors: Sim Eunbi , Bierema Laura L. 
Published: January 2025

PurposePrecarious workers in academia represent most employees in higher education institutions (HEIs), and women and historically excluded groups are overrepresented in these positions, oppressed by intersecting inequities, such as sexism and racism. There is a need to comprehensively understand how precarity operates within academia from an intersectional perspective and how it oppresses marginalized and precarious workers.Design/methodology/approachFollowing the PRISMA guidelines, this paper systematically reviewed 22 articles that discuss academic precarity through an intersectional lens.FindingsStudies have shown that (1) the uncertainty and insecurity in modern academia are driven by global forces and ongoing crises; (2) systemic intersectionality entrenched in HEIs influenced the shaping of their academic experiences and positionalities; and (3) intersectionality could be used as a reflexive tool to resist the precarious academy.Originality/valueThis paper is the first systematic review examining the intersectionality in precarious academia. By synthesizing articles highlighting precarity and intersectionality in academia, the paper contributes to theories of academic capitalism and intersectionality and offers comprehensive and critical implications for research and practice in higher education. This study illuminates how neoliberalism, global capitalism and intersecting inequities are deeply rooted in academia and how academic workers could challenge such issues.
Impact of technology-based collaborative learning on students’ competency-based education: insights from the higher education institution of Pakistan
Authors: Asad Muhammad Mujtaba , Qureshi Anum 
Published: January 2025

PurposeTechnology-based collaborative learning (TBCL) is the manner in which students can use technological tools and digital platforms to share knowledge and learn collaboratively. It can help increase students’ participation, motivation and achievement due to the stimulating teaching environment. The study intends to examine the effect of TBCL on students’ competency-based education (CBE).Design/methodology/approachA questionnaire as quantitative data gathering tool is employed in this correlational study. This study used purposive sampling which is done on undergraduate university students (N = 187) in order to accomplish the goal. The data are analyzed using the SPSS software (Statistical Package for Social Sciences) version 27.0.FindingsThe findings of this study indicate the strong positive association between the TBCL and students’ CBE with the correlation coefficient value 0.993. Hence, the null hypothesis is rejected, and alternative hypothesis of this study is accepted.Practical implicationsThe findings will provide valuable insights that will help educators, policymakers, industry partners and researchers better prepare students for the demands of the digital age and improve the quality of education by identifying successful strategies for integrating technology into collaborative learning environments.Originality/valueThis study is unique because it synthesizes and analyzes previous research to look at the particular context of TBCL and how it affects students' CBE in higher education institution in Sindh that was not previously investigated.
Enhancing eWOM effectiveness: the interplay of endorsement styles and emoji in digital persuasion
Authors: Wei Yuzhi , Yan Huili , Shen Chenxin , Xiong Hao 
Published: January 2025

Purpose
The strategic application of electronic word-of-mouth (eWOM) is pivotal in shaping tourist decisions. This study aims to examine the nuanced impacts of endorsement styles and the innovative role of emojis on the persuasiveness of eWOM, highlighting essential insights for digital marketing effectiveness.

Design/methodology/approach
Using a robust experimental design, this research engaged 376 participants through scenario-based experiments on popular platforms Ctrip and Xiaohongshu. This study leveraged the professional online data platform, Credamo, to ensure a diverse and representative sample.

Findings
The analysis demonstrates that implicit endorsements, such as “I like this restaurant,” consistently outperform explicit endorsements like “I recommend this restaurant” regarding persuasiveness. This effect is attributed to the enhanced perceived authenticity and reduced persuasion knowledge activation by implicit endorsements. Remarkably, incorporating emojis within explicit endorsements mitigates their inherent drawbacks, enhancing their persuasive impact. In contrast, emojis do not significantly influence the effectiveness of implicit endorsements.

Practical implications
The findings provide significant insights, demonstrating that endorsement styles and emojis play a crucial role in identifying persuasive eWOM and fostering the creation of compelling eWOM for tourism and hospitality marketers. These elements can help marketers effectively track and enhance the impact of eWOM in their digital strategies.

Originality/value
This research maps the effects of endorsement styles and highlights the strategic role of emojis in eWOM, offering practical insights for maximizing persuasion and enhancing digital marketing strategies in tourism and hospitality.
Leader STARA competence and green competitiveness in tourism and hotel enterprises: leveraging green creativity and human capital
Authors: Khairy Hazem Ahmed , Lee Yee Ming , Al-Romeedy Bassam Samir 
Published: January 2025

PurposeThis study aimed to investigate the impact of leader STARA competence (LSC) – managing and implementing smart technologies, artificial intelligence, robotics and algorithms– on green competitiveness (GC) in the tourism and hospitality sectors. It also investigated the role of employee green creativity (EGC) as a mediator between LSC and GC and the mediating role of green human capital (GHC) in the relationship between EGC and GC.Design/methodology/approachThe study utilized PLS-SEM to analyze 320 responses obtained from middle-level management at five-star hotels and travel agencies in Egypt, using WarpPLS statistical software 7.0.FindingsLeader STARA competence positively affects employee green creativity and green competitiveness. Employee green creativity positively affects green competitiveness and green human capital. Green human capital positively affects green competitiveness. In addition, the study demonstrated significant mediation roles of green human capital in the employee green creativity and green competitiveness relationship and employee green creativity in the leader STARA competence and green competitiveness relationship.Practical implicationsThe study offers several practical implications for tourism and hospitality enterprises. It underscores the significance of leader STARA’s competence in advancing green competitiveness.Originality/valueThe study provides new insights into how emerging concepts like leader STARA competence, green human capital and employee green creativity simultaneously predict green competitiveness within tourism and hospitality enterprises. It also contributes significantly to enriching the social exchange theory.
Price premiums for geographical indication under the coexistence of self‐claims and certification
Authors: Wang Meng , Ge Jihong , Fan Xuesen , Hu Wuyang 
Published: January 2025

AbstractAs the popularity of geographical indication (GI) grows in developing countries, the coexistence of GI self‐claims and certification has become widespread. This study focusses on the Chinese rice market and explores the market performance of GI self‐claims and certification. The findings indicate that while GI self‐claims can generate price premiums, these are lower than those generated by GI certification. In the mid‐to‐high‐end rice market, GI self‐claims barely succeed to generate any price premium, whereas GI certification maintains its competitiveness. Notably, there is heterogeneity in the price premiums of different types of GI self‐claims and certification. On the one hand, only indirect self‐claims, which utilise origin information denoted by a GI label, can generate a price premium. On the other hand, GI certification promoted in earlier years or with more stringent certification standards generates higher price premiums. There is no clear evidence suggesting that a higher number of GI certificates corresponds to higher price premiums.
Formation of the Central Tibet Watershed Mountains in the Late Jurassic: Evidence From Provenance Mapping of the Source‐to‐Sink System in the Qiangtang Basin
Authors: Zhang Jiawei , Li Yalin , Tu Jiarun , Han Zhongpeng , Dai Jingen , Zhang Huiping , Kang Huan 
Published: January 2025

ABSTRACTThe Central Tibet Watershed Mountains (CTWMs) are located in the hinterland of the Tibetan Plateau, extending over 1000 km from west to east. These mountains currently function as a drainage divide, separating Tibet's rivers into eastward‐ and southward‐flowing systems to the north and the south of the mountains, respectively. The timing of watershed formation remains contentious, which hinders a comprehensive understanding of the geomorphic evolution of the Tibetan Plateau. The Qiangtang basin, where the CTWMs are situated, preserves critical geological records essential for deciphering landscape evolution. The age distributions of new detrital zircon U–Pb data from the Middle and Upper Jurassic sandstones in the northern Qiangtang sub‐basin are consistent with a published data set, with age clusters at 200–300, 500–700, 800–1000, 1800–2000 and 2400–2600 Ma. Qualitative provenance analysis identifies the major source rocks as the Palaeozoic and Upper Triassic strata in the CTWMs, as well as the Triassic turbidites in the Hoh Xil‐Songpan Ganze terrane (HSG), which bound the northern Qiangtang sub‐basin to the south and north, respectively. Minor contributions come from Late Triassic intrusive and volcanic rocks, as well as Jurassic granitoids. The abundant detrital zircon data from the Qiangtang basin offers an opportunity to investigate the formation of the CTWMs through a quantified interpretation of the source‐to‐sink system. The combination of inverse and forward modelling of large detrital data sets facilitates the creation of provenance maps and avoids laborious descriptions of individual age modes. Integrated with sandstone petrographic analysis and paleocurrent data, the provenance of the Jurassic sediments can be quantitatively constrained. The CTWMs within the Qiangtang basin consistently served as significant sources throughout the Jurassic, while younger zircon grains were contributed by local sources, including the Triassic and Jurassic magmatic rocks. The proportion of the HSG source in the north increased throughout the basin in the Middle Jurassic but decreased dramatically in the southern Qiangtang sub‐basin during the Late Jurassic. We interpret that the embryonic stage of the CTWMs, which did not fully prevent sediment transport from the HSG to the southern Qiangtang sub‐basin, persisted from the Early to Middle Jurassic. The formation of a well‐defined watershed occurred in central Tibet in the Late Jurassic, probably triggered by the trench‐parallel mid‐ocean ridge subduction of the Bangong‐Nujing oceanic lithosphere.