bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of clinical characteristics of thyroid disorders in patients with chronic hepatitis B treated with pegylated-interferon alpha
Authors: Liu Yisi , Zheng Yanhong , Lin Xiao , Cao Zhenhuan , Lu Junfeng , Ma Lina , Ren Shan , Zheng Sujun , Hu Zhongjie , Xu Bin , Chen Xinyue 
Published: March 2023

Abstract
Background
Thyroid disorders (TD) is a common complication of pegylated-interferon alpha (Peg-IFNα) therapy. Few studies have investigated the relationship between TD and the efficacy of interferon therapy for chronic hepatitis B. Therefore, we analyzed the clinical characteristics of TD in patients with chronic hepatitis B (CHB) treated with Peg-IFNα, and evaluated the correlation between TD and Peg-IFNα treatment efficacy.
Methods
In this retrospective study, the clinical data of 146 patients with CHB receiving Peg-IFNα therapy were collected and analyzed.
Results
During the course of Peg-IFNα therapy, positive conversion of thyroid autoantibodies and TD occurred in 7.3% (85/1158) and 8.8% (105/1187) patients, respectively, and was diagnosed more often in women. The most common thyroid disorder was hyperthyroidism (53.3%), followed by subclinical hypothyroidism (34.3%). We found that thyroid function returned to normal in 78.7% of patients with CHB, and thyroid antibody levels returned to the negative range in approximately 50% of patients after interferon treatment cessation. Only 25% of patients with clinical TD required treatment. Compared with patients with hypothyroidism/subclinical hypothyroidism, patients with hyperthyroidism/subclinical hypothyroidism showed greater reduction and seroclearance of hepatitis B surface antigen (HBsAg) levels.
Conclusions
TD are not an absolute contraindication for interferon therapy; however, patients should be monitored closely during interferon therapy. In pursuit of functional cure, a balance between efficacy and safety must be achieved.
Stigma associated with mental stress and reduced quality of life among HIV-infected women in western China:a cross-sectional study
Authors: Feng Ying , Xia Yan , Guo Rui , Li Yuefei , He Qian , Ni Mingjian 
Published: March 2023

Abstract
Background: Stigma has been identified as a crucial risk factor for mental stress and quality of life among HIV-infected patients. However, little attention has been paid to these factors among Asian populations and women rendered vulnerable by their psychological characteristics. In addition, the relationships between stigma, social capital, mental stress and quality of life remain to be elucidated.
Methods: A total of 553 HIV-infected women were recruited in Xijiang, China from September 2021 to August 2022. Stigma was assessed using the 12-item Short HIV Stigma scale; mental stress (anxiety, depression) was assessed using the 20-item Self-Rating Anxiety scale (SAS) and 10-item Center for Epidemiological Studies Depression (CESD) scale; social capital was assessed using the Personal Social Capital Scale (PSCS-8);quality of lifewas assessed using the WHO QOL-HIV-BREF scale.
A generalized linear model (GLM) and structural equation model (SEM) were used to examine the associations between stigma, social capital, mental stress and quality of life.
Results: The HIV-related stigma scale showed actual discrimination score 6.57±2.56, fear of publicity score 7.31±2.34, public attitude score 6.56±2.52, and negative self-image score 6.74±2.55. Quality of life scores were 11.87±2.33 (physiological domain), 9.91±2.42 (psychological domain), 13.31±3.17 (social relation domain) and 11.19±2.84 (environmental domain). SAS-20 and CESD-10 scores were 81.25±50.11 and 9.02±5.55, respectively. After adjusting for age, education, marital status, employment status, residence and monthly income, each 10-point increase in stigma score was associated with 49.3% (OR=1.493, 95%CI:1.218, 1.840) and 51.5% (OR=1.515, 95%CI:1.235, 1.868) increases in anxiety symptoms and depression risk, respectively. In the SEM, stigma was associated with mental stress (β=0.25, p=0.014), which decreased the quality of life of HIV-positive women (β=0.17, p=0.032). The direct effect of social capital on mental stress was significant (β=0.18, p=0.033).
Conclusion: Stigma and depression play important roles in quality of life among HIV-infected women. Immediate measures should be taken to reduce stigma and provide psychological guidance, which might contribute to decreasing mental stress and improving quality of life among HIV-infected women.
HBsAg ≤ 135 IU/mL or HBcrAg ≤ 3.6 logU/mL was associated with HBsAg loss after nucleos(t)ide analogue cessation
Authors: Xie Yandi , Li Minghui , Ou Xiaojuan , Zheng Sujun , Gao Yinjie , Xu Xiaoyuan , Yang Ying , Ma Anlin , Li Jia , Nan Yuemin , Zheng Huanwei , Liu Juan , Wei Lai , Feng Bo 
Published: March 2023

Abstract
Background
Since hepatitis B surface antigen (HBsAg) loss is rarely achieved with nucleos(t)ide analogue (NA) treatment, most patients require life-long NA treatment. Previous studies have shown that a proportion of patients remained virological response after NA cessation. Whether NA discontinuation can increase HBsAg loss rate is still under controversial. This study was conducted to assess the cumulative rate of HBsAg loss and identify predictors of HBsAg loss after NA discontinuation
Methods
In this multicenter prospective study, initially HBV e antigen (HBeAg)-positive patients without cirrhosis who met the stopping criteria were included from 12 hospitals in China. Enrolled patients stopped NA and were followed up with clinical and laboratory assessments every 3 months for 24 months after NA cessation or until clinical relapse (CR) occured.
Results
Overall 158 patients were divided into two groups. Group A included patients with HBsAg positive when NA cessation (n=139) and Group B included patients with HBsAg negative when NA cessation (n=19). In Group A, the 12-month and 24-month cumulative rates of HBsAg loss were 4.3% and 9.4%, respectively. End of treatment (EOT) HBsAg (hazard ratio (HR) = 0.152, P < 0.001) and EOT hepatitis B core-related antigen (HBcrAg) (HR = 0.257, P = 0.001) were associated with HBsAg loss. The area under the receiver operating characteristic value of the EOT HBsAg and HBcrAg were 0.952 (P < 0.001) and 0.765 (P< 0.001), respectively. Patients with EOT HBsAg ≤ 135 IU/mL (59.2% vs 1.3%, P < 0.001) or HBcrAg ≤ 3.6 logU/mL (17% vs 5.4%, P = 0.027) had higher 24-month cumulative HBsAg loss rate. In Group B, none of patients had virological relapse after NA cessation. Only 1 (5.3%) patient had HBsAg reversion.
Conclusions
EOT HBsAg ≤ 135 IU/mL or HBcrAg ≤ 3.6 logU/mL can identify patients with more chance to be HBsAg loss after NA cessation. Patients with HBsAg negative when NA cessation have favorable clinical outcomes and HBsAg loss was durable in most cases.
Intelligent analytics algorithms in breach detection systems for securing VANETs and data for smart transportation management
Authors: J Bhuvana , HASHMI HINA , Adhvaryu Rachit , Kashyap Sneha , Kumari Savita , Wadhwa Durgesh 
Published: March 2023

Abstract
In-vehicle communication has developed into a crucial element of today's driving environment as a result of the expanding additions of sensor-centric communication as well as computing devices inside a vehicle for a variety of purposes, consists of vehicle monitoring, physical wiring minimization as well as driving efficiency. The relevant literature on cyber security for in-vehicle communication methods does not, however, currently offer any certain solutions for in-vehicle cyber hazards. The existing solutions, which mostly rely on protocol-specific security approaches, do not provide a comprehensive security framework for in-vehicle communication. This study aims to develop an effective data transmission and intelligent machine learning technique for smart vehicle management in VANET breach detection. In this study, ensemble adversarial Boltzmann CNN architecture is used to detect breaches. The secure short hop opportunistic local routing protocol is then used to send the data. Throughput, QoS, training accuracy, validation accuracy, and network security analysis are all part of the experimental analysis for a variety of security-based datasets. the proposed technique attainedthroughput of 88%, QoS of 77%, training accuracy of 93%, validation accuracy of 96%, network security analysis of 63%, scalability of 75%.
Association between Breakfast Frequency and Metabolic Syndrome among young adults in South Korea
Authors: Kim Hyo Myoung , Kang Hyun Jung , Lee Dong Hoon , Jeong Su-Min , Joh Hee-Kyung 
Published: March 2023

Abstract
Skipping breakfast is highly prevalent but it is not clear whether breakfast frequency is associated with metabolic syndrome in young adults. We aimed to assess the association between breakfast frequency and metabolic syndrome in Korean young adults. This cross-sectional study was based on health check-up data of university students aged 18-39 years between 2016 and 2018. Participants were stratified into three groups based on breakfast frequency (non-skipper, skipper for 1-3 days per week, and skipper for 4-7 days per week). Meal patterns were classified into healthy, fair, and unhealthy patterns by combination of breakfast frequency, binge eating frequency, and meal regularity. Multivariable-adjusted logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) of metabolic syndrome. Of the total 12,302 participants, 56.8% skipped breakfast for 3 days or more per week. The prevalence of metabolic syndrome was higher among participants skipping breakfast for 3 days or more per week than non-skipper (3.1% vs. 1.7%). In the age- and sex-adjusted model, individuals skipping breakfast for 4-7 days per week had a higher OR of metabolic syndrome (OR 1.73, 95% CI 1.21-2.49) compared to non-skipper. Although this association became insignificant (OR 1.49, 95% CI 0.99–2.23) after multivariable adjustment, trends of positive association between frequency of breakfast skipping and metabolic syndrome was significant (P for trend = 0.038). Among components of metabolic syndrome, high blood pressure was significantly associated with frequent breakfast skipping (OR 1.34, 95% CI 1.09-1.65). Binge eating and having irregular meals was not significantly associated with metabolic syndrome. Individuals with unhealthy meal patterns had a higher OR of metabolic syndrome compared to those with healthy meal patterns (OR 1.80, 95% CI 1.02-3.19). Frequent skipping breakfast was associated with higher odds of metabolic syndrome in young adults. Unhealthy meal patterns were significantly associated with higher odds of metabolic syndrome (p < 0.001). Further longitudinal studies in the long term are needed to understand the association of meal patterns with metabolic syndrome.
WITHDRAWN: Roughness in L-algebras
Authors: Zhan Qiuyan , Saeid A. Borumand 
Published: March 2023

Abstract
The aim of this paper is to introduce rough approximation on L−algebras. We investigate the relationship between subalgebras, ideals and rough subalgebras, rough ideals of L−algebras, and study homomorphic images of rough ideals on L−algebras. Furthermore, the rough set algebra as an L−algebra is expressed by select the implication operator appropriately. Continue the study of fuzzy set theory on L−algebras, we apply rough fuzzy set theory on L−algebras, we construct a representation theorem that determines when a pair of fuzzy sets is a rough fuzzy set on L−algebras. Finally, uncertainty measures on L−algebras and the relationship between rough operations and uncertainty measures of L−algebras are studied. We verify that there is a bijection between the low approximation and inner measure on L−algebras.
MSC(2010): 03B50, 06A15, 03B47, 03E72.
Does non-farm employment increase rural households’ consumption: Empirical Evidence from West Ethiopia?
Authors: Dufera Wakuma , Bedemo Amsalu , Kebede Temesgen 
Published: March 2023

Abstract
In rural areas where the farmer's livelihood is based on farming, non-farm activity was considered as an additional source of income that plays an important role in improving household consumption. The Hackman results indicate that non-farm participation decision of households has positive significant effect on their level of household consumption. Incomes of the household, education level and family size have positive significant effect on household consumption. Variables such as education, access to credit, membership to iqub, household health status, access to training, and own savings, were identified to be the main factors positively influencing household decision to non-farm with a statistical significant level. The study's recommendation was; provide various pieces of farm and non-farm training provide the infrastructure that is a barrier to rural development and develop the culture of saving in the community.
A systematic literature review of the HPV prevalence in locally-regionally advanced (LA) and recurrent/metastatic (RM) head and neck cancers through the last decade: The ‘ALARM’ study
Authors: Agelaki Sofia , Boukovinas Ioannis , Athanasiadis Ilias , Trimis Georgios , Dimitriadis Ioannis , Poughias Lazaros , Morais Edith , Ugne Sabale , Bencina Goran , Charalampos Athanasopoulos 
Published: March 2023

Abstract
Background: ‘ALARM’ is a systematic review of available literature aiming to provide updated information on the prevalence of Human Papillomavirus (HPV) in locally-regionally advanced (LA) and recurrent/metastatic (RM) head and neck cancer (HNC) worldwide.
Methods: Electronic searches were conducted on clinicaltrials.gov, MEDLINE (via Pubmed), Embase and ASCO/ESMO journals of congresses for interventional studies (IS; phase I-III trials) as well as MEDLINE and Embase for non-interventional studies (NIS) of LA/RM HNC published between 01Jan2010 and 31Dec2020. Criteria for study selection included: availability of HPV prevalence data for patients with LA/RM HNC, patient enrollment from 01Jan2010 onwards, and oropharyngeal cancer (OPC) included among HNC types. HPV prevalence per study was calculated as proportion of HPV-positive (HPV+) over total number of HNC enrolled patients. For overall HPV prevalence across studies, mean of reported HPV prevalence rates across studies and pooled estimate, i.e., sum of all HPV+ patients over sum of all HNC patients enrolled, were assessed.
Results: Eighty-one studies (62 IS; 19 NIS) were included in this evidence synthesis, representing 9607 LA/RM HNC cases, with an overall mean (pooled) HPV prevalence of 32.6% (25.1%). HPV prevalence was 44.7% (44.0%) in LA and 24.3% (18.6%) in RM. Among 2714 LA/RM OPC patients from 52 studies with available data, the mean (pooled) value was 55.8% (50.7%). The majority of published HPV prevalence data were derived from countries in Northern America and Europe, with overall HPV prevalence of 46.0% (42.1%) and 24.7% (25.3%) across studies conducted exclusively in these geographic regions, respectively. Mean (pooled) HPV prevalence in Northern Europe was 31.9% (63.1%), numerically higher than the European average. A “p16-based” assay was the most frequently reported HPV detection methodology (58.0%).
Conclusion: Over the last decade, at least one quarter of LA/RM HNC and half of OPC cases studied in IS and NIS were HPV+, with variation across disease stages and geographic regions. This alarming burden is consistent with a potential implication of HPV in the pathogenesis of at least a subgroup of HNC. The observed rates underscore the relevance of HPV testing and prophylaxis to the prevention and management of these cancers.
PROSPERO Number: CRD42021256876
Identifying pathological differentiation of cervical squamous cell carcinoma with APTw and IVIM
Authors: Xin Zhonghong , Peng Jianhong , Lian Jianxiu , Lu Xiande , Nan Jiang , Zhang Yaping , Chen Zixian , Wang Xiaohui , Zhu Jun , Lei Junqiang 
Published: March 2023

Abstract
Background
Cervix Squamous cell carcinoma(CSCC) is the most common pathological subtypes of cervix carcinoma(CC). CSCC can be divided into poorly differentiated, moderately differentiated and well-differentiated types. The pathological differentiation is essential for the treatment and prognosis of CSCC. Compared with the well-differentiated CSCC patients, poorly differentiated CSCC patients have poor clinical prognosis. The biopsy is the golden standard for identifying pathological differentiation with the disadvantages including invasive. Therefore, an imaging method is needed to determine the degree of tumor differentiation before surgery.
Purpose
The objective is to explore APTw and IVIM values in diagnosing the differentiation degree of cervical squamous cell carcinoma (CSCC).
Methods
APTw was scanned by using 3D Multi-shot TSE for obtaining APT signal intensity (APT SI). IVIM was scanned by using 12 b values (0, 20, 100, 150, 200, 300, 400, 500, 600, 800, 1000 and 1200 s/mm2) to calculate parameters: D, D*, and f. ADC was calculated based on 2 b values (0, 800 s/mm2). The parameters among different groups were compared by t-tests. Diagnostic performance was evaluated with a ROC analysis.
Results
56 patients and 30 healthy volunteers were included in study. Patients were divided into: a well-moderately differentiated group (n = 34) and a poorly differentiated group (n = 22). The parameters (APT SI, ADC, D, f) were statistically significantly different between CSCC and normal cervix. APT SI of the CSCC was higher than that of normal cervix (P < 0.001). The ADC, D, and f of the CSCC were lower than those of normal cervix (P < 0.001). Significant differences were found in APT SI and D between the well-moderately differentiated and poorly differentiated group (P < 0.001). Comparing the well-moderately differentiated and poorly differentiated group, AUC of APT SI, D and f were 0.789, 0.775 ,and 0.670, sensitivity were 72.73%, 68.18%, 77.27%, and specificity were 79.41%, 82.35%, 64.71%, respectively (P < 0.05).
Conclusion
APTw and IVIM can be used to diagnose CSCC and provide accurate quantitative information. Compared with IVIM, APTw has higher diagnostic performance in identifying the differentiation degree of CSCC.
WITHDRAWN: Robust Egyptian Arabic License Plate Character Recognition Approach from Moving Vehicles
Authors: SayedElahl M. A. 
Published: March 2023

Abstract
The recognition of Arabic license plates from moving vehicles is a highly demanding task in the field of computer vision. This problem is relevant to various applications such as cross-border security, law enforcement, and intelligent transportation systems. The goal of this task is to accurately identify the characters on the license plate, despite the challenges posed by different lighting conditions, font styles, and aspect ratios of characters. This paper proposes a new and robust method for recognizing Arabic license plates from moving vehicles. The method utilizes an enhanced expert system that combines the power of deep learning and domain-specific knowledge to address the challenges posed by variations in lighting conditions, font styles, and aspect ratios. The system localizes the license plate in an image using an object detection model, followed by the segmentation and recognition of individual characters using a character recognition model trained with deep neural networks. The results of experiments in various outdoor settings demonstrate the superiority of the proposed method over existing methods in terms of recognition accuracy and robustness. This study represents an important step towards the development of practical license plate recognition systems and has potential applications in cross-border security, law enforcement, and intelligent transportation systems.
A ‘golden’ alternative for prevention of cisplatin nephrotoxicity in bladder cancer
Authors: Sharon Yoray , Motiei Menachem , Tzror-Azankot Chen , Sadan Tamar , Popovtzer Rachela , Rosenbaum Eli 
Published: March 2023

Abstract
Cisplatin (CP) is the first-line standard of care for bladder cancer. However, a significant percentage of advanced bladder cancer patients are ineligible to receive standard CP treatment, due to the drug’s toxicity, and in particular its nephrotoxicity. These patients currently face suboptimal therapeutic options with lower efficacy. To overcome this limitation, here we designed CP-conjugated gold nanoparticles (GNPs) with specific properties that prevent renal toxicity, and concurrently preserve the therapeutic efficacy of CP. Safety and efficacy of the particles were studied in bladder tumor-bearing mice, using clinically-relevant fractionated or non-fractionated dosing regimens. A non-fractionated high dose of CP-GNP showed long-term intratumoral accumulation, blocked tumor growth, and nullified the lethal effect of CP. Treatment with fractionated lower doses of CP-GNP was also superior to an equivalent treatment with free CP, demonstrating both anti-tumor efficacy and prolonged mouse survival. Moreover, as opposed to free drug, CP-conjugated GNPs did not cause fibrosis or necrosis in kidney. These results indicate that conjugating CP to GNPs can serve as an effective, combined anti-cancer and renoprotective approach, and thus has potential to widen the range of patients eligible for CP-based therapy.
Bovine milk derived exosomes affect gut microbiota of DSS-induced colitis mouse
Authors: Li Tonghao , Chen Xiaolin , Liu Yuhang , Hua Rong , Qi Qien , Feng Xin 
Published: March 2023

Abstract
We hypothesized that oral administration of bovine milk derived exosomes (MDEs) can positively regulate the gut microbiota thus may alleviate the Dextran sodium sulfate (DSS)-induced colitis in mice. Total of 42 specific pathogen free (SPF) male BALB/c mice (3 weeks old) were randomly assigned to three groups including control/blank group (Blnk), DSS group (DSS) and Exosome group (Exo), with 7 replicates/cages per treatment and two mice in one cage. 16S rRNA gene sequencing of cecal digesta samples was conducted. DSS significantly decreased the average daily feed intake of mice in DSS and Exo groups (P = 0.03). Shannon index of the DSS group was significantly lower than the Blnk group (P < 0.05) whereas no difference between the Blnk group and Exo group were observed. Administration of MDEs tended to increase the relative abundance of Campylobaterota. The relative abundance of Roseburia was significantly decreased in the DSS group compared to the Blnk group (P < 0.05) whereas no difference was observed between the Exo group and Blnk group. Oral gavage of MDEs also tended to increase the relative abundance of Lachnospiraceae_UCG_006. In conclusion, oral gavage of 10 µL MDEs (1 mg/ml) affected gut microbiota of DSS-induced colitis mouse but the effects were limited.
A Novel Approximation Method for the Solution of Coupled Nonlinear Systems
Authors: Johnston Daniel , Cartmell Matthew 
Published: March 2023

Abstract
In this paper, we describe and illustrate the application of a novel approximation technique for coupled, nonlinear dynamic systems. The technique begins by obtaining the analytical (or approximate analytical) solutions to the uncoupled system. Then, these solutions are used to approximate particular terms in the fully-coupled, nonlinear system in such a way that the target system is amenable to (approximate) analytical solution algorithms. This work forms part of a larger effort to develop robust control systems for large-scale industrial manipulators. To this end, the final example examined in this work considers the FutureForge manipulator: a state-of-the-art manipulator which forms part of a next-generation forging platform under development at the Advanced Forming Research Centre in Glasgow. To show the breadth of applications of our approach, we also apply it to more widely-recognised models like the Rayleigh and Van der Pol oscillators. In both of these cases, we consider a system of two oscillators each having dynamic behaviour described by Rayleigh/Van der Pol oscillators and coupled together through the resulting damping matrices.