bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late-fall satellite-based soil moisture observations show clear connections to subsequent spring streamflow
Authors: Koster Randal D. , Liu Qing , Crow Wade T. , Reichle Rolf H. 
Published: June 2023

AbstractBecause runoff production is more efficient over wetter soils, and because soil moisture has an intrinsic memory, soil moisture information can potentially contribute to the accuracy of streamflow predictions at seasonal leads. In this work, we use surface (0–5 cm) soil moisture retrievals obtained with the National Aeronautics and Space Administration’s Soil Moisture Active Passive satellite instrument in conjunction with streamflow measurements taken within 236 intermediate-scale (2000–10,000 km2) unregulated river basins in the conterminous United States to show that late-fall satellite-based surface soil moisture estimates are indeed strongly connected to subsequent springtime streamflow. We thus show that the satellite-based soil moisture retrievals, all by themselves, have the potential to produce skillful seasonal streamflow predictions several months in advance. In poorly instrumented regions, they could perform better than reanalysis soil moisture products in this regard.
SEC-seq: association of molecular signatures with antibody secretion in thousands of single human plasma cells
Authors: Cheng Rene Yu-Hong , de Rutte Joseph , Ito Cade Ellis K. , Ott Andee R. , Bosler Lucie , Kuo Wei-Ying , Liang Jesse , Hall Brian E. , Rawlings David J. , Di Carlo Dino , James Richard G. 
Published: June 2023

Abstract
The secreted products of cells drive many functions in vivo; however, methods to link this functional information to surface markers and transcriptomes have been lacking. By accumulating secretions close to secreting cells held within cavity-containing hydrogel nanovials, we demonstrate workflows to analyze the amount of IgG secreted from single human B cells and link this information to surface markers and transcriptomes from the same cells. Measurements using flow cytometry and imaging flow cytometry corroborate the association between IgG secretion and CD38/CD138. By using oligonucleotide-labeled antibodies we find that upregulation of pathways for protein localization to the endoplasmic reticulum and mitochondrial oxidative phosphorylation are most associated with high IgG secretion, and uncover surrogate plasma cell surface markers (e.g., CD59) defined by the ability to secrete IgG. Altogether, this method links quantity of secretion with single-cell sequencing (SEC-seq) and enables researchers to fully explore the links between genome and function, laying the foundation for discoveries in immunology, stem cell biology, and beyond.
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity
Authors: Fixsen Bethany R. , Han Claudia Z. , Zhou Yi , Spann Nathanael J. , Saisan Payam , Shen Zeyang , Balak Christopher , Sakai Mashito , Cobo Isidoro , Holtman Inge R. , Warden Anna S. , Ramirez Gabriela , Collier Jana G. , Pasillas Martina P. , Yu Miao , Hu Rong , Li Bin , Belhocine Sarah , Gosselin David , Coufal Nicole G. , Ren Bing , Glass Christopher K. 
Published: June 2023

AbstractSpalt-like transcription factor 1 (SALL1) is a critical regulator of organogenesis and microglia identity. Here we demonstrate that disruption of a conserved microglia-specific super-enhancer interacting with theSall1promoter results in complete and specific loss ofSall1expression in microglia. By determining the genomic binding sites of SALL1 and leveragingSall1enhancer knockout mice, we provide evidence for functional interactions between SALL1 and SMAD4 required for microglia-specific gene expression. SMAD4 binds directly to theSall1super-enhancer and is required forSall1expression, consistent with an evolutionarily conserved requirement of the TGFβ and SMAD homologsDppandMadfor cell-specific expression ofSpaltin theDrosophilawing. Unexpectedly, SALL1 in turn promotes binding and function of SMAD4 at microglia-specific enhancers while simultaneously suppressing binding of SMAD4 to enhancers of genes that become inappropriately activated in enhancer knockout microglia, thereby enforcing microglia-specific functions of the TGFβ–SMAD signaling axis.
Effects of urban living environments on mental health in adults
Authors: Xu Jiayuan , Liu Nana , Polemiti Elli , Garcia-Mondragon Liliana , Tang Jie , Liu Xiaoxuan , Lett Tristram , Yu Le , Nöthen Markus M. , Feng Jianfeng , Yu Chunshui , Marquand Andre , Schumann Gunter ,   the environMENTAL Consortium, Walter Henrik , Heinz Andreas , Ralser Markus , Twardziok Sven , Vaidya Nilakshi , Serin Emin , Jentsch Marcel , Hitchen Esther , Eils Roland , Taron Ulrike-Helene , Schütz Tatjana , Schepanski Kerstin , Banks Jamie , Banaschewski Tobias , Jansone Karina , Christmann Nina , Meyer-Lindenberg Andreas , Tost Heike , Holz Nathalie , Schwarz Emanuel , Stringaris Argyris , Neidhart Maja , Nees Frauke , Siehl Sebastian , A. Andreassen Ole , T. Westlye Lars , van der Meer Dennis , Fernandez Sara , Kjelkenes Rikka , Ask Helga , Rapp Michael , Tschorn Mira , Böttger Sarah Jane , Novarino Gaia , Marr Lena , Slater Mel , Viapiana Guillem Feixas , Orosa Francisco Eiroa , Gallego Jaime , Pastor Alvaro , Forstner Andreas , Hoffmann Per , M. Nöthen Markus , J. Forstner Andreas , Claus Isabelle , Miller Abbi , Heilmann-Heimbach Stefanie , Sommer Peter , Boye Mona , Wilbertz Johannes , Schmitt Karen , Jirsa Viktor , Petkoski Spase , Pitel Séverine , Otten Lisa , Athanasiadis Anastasios-Polykarpos , Pearmund Charlie , Spanlang Bernhard , Alvarez Elena , Sanchez Mavi , Giner Arantxa , Hese Sören , Renner Paul , Jia Tianye , Gong Yanting , Xia Yunman , Chang Xiao , Calhoun Vince , Liu Jingyu , Thompson Paul , Clinton Nicholas , Desrivieres Sylvane , H. Young Allan , Stahl Bernd , Ogoh George 
Published: June 2023

AbstractUrban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group (r = 0.22, Pperm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1, explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group (r = 0.10, Pperm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3, explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group (r = 0.03, Pperm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways.
The first comprehensive population size estimations for the highly endangered largest diving beetle Dytiscus latissimus in Europe
Authors: Balalaikins M. , Schmidt G. , Aksjuta K. , Hendrich L. , Kairišs K. , Sokolovskis K. , Valainis U. , Zolovs M. , Nitcis M. 
Published: June 2023

AbstractDytiscus latissimus(Coleoptera Dytiscidae) is an endangered diving beetle throughout its range. It is one of the two species of Dytiscidae listed in Annex II of the Habitats Directive, IUCN red list and in many national level legislations and therefore strictly protected. The conservation of endangered species first of all requires an assessment of their population size. Until now, a method has not been developed for estimating the size ofD.latissimuspopulations. The article summarizes the results of two studies carried out independently in Germany and Latvia. Both studies were carried out in one water body used recapture method but with a different spatial placement of traps, which, according to our data, is an important factor in population estimation. We evaluated Jolly-Seber and Schnabel approaches of estimating aquatic beetle's populations and found that confidence intervals obtained by different methods in our research do not differ significantly, but combination of both models provide the most accurate estimates of population dynamics. As part of the study, we concluded that the populations ofDytiscus latissimusare relatively closed, so we accept that the Schnabel estimate shows more accurate data. By fixing the places of capture of each individual, it was found that females live mainly locally, and males actively move within the water body. This aspect indicates the advantage of the spatial placement of traps compared to the use of transects. The results of our study show a significantly higher number of both captured and recaptured males Such a sex ratio may indicate both a greater activity of males and differences in the sex ratio in the population. The study confirmed that environmental changes, such as the water level in a water body, can also significantly affect the result of a population assessment. In the frame ofD. latissimusmonitoring, to obtain an objective estimation of the species population size we recommend using four traps for each 100 m of water body shoreline with 4–8 censuses, dependently on the recapture rate.
Feasibility, safety and effectiveness of mapping system assisted conduction system pacing: a single-center prospective study
Authors: Wang Liang , Yang Suxia , Tang Baopeng , Wang Feifei , Sang Wanyue , Han Yafan , Wang Lu , Zhou Xianhui , Zhang Jianghua , Xing Qiang , Tuerhong Zukela , Xiaokereti Jiasuoer , Guo Yankai , Li Yaodong 
Published: June 2023

AbstractTo assess pacing and electrophysiological parameters, as well as mid-term outcomes, among patients undergoing His bundle pacing (HBP) guided by KODEX-EPD (a novel mapping system). Consecutive patients undergoing conduction system pacing (CSP) for bradycardia indications were evaluated. Procedural and fluoroscopic times and pacing characteristics were compared between conventional fluoroscopy (the standard group, N = 20 cases) and KODEX-EPD mapping system guided group (the KODEX group, N = 20cases) at CSP implantation and all patients were followed at 6-month. HBP was achieved in all patients (the standard group 20/20 and the KODEX group 20/20). There was no difference in the mean procedure time between the two groups (63.7 ± 9.3 vs. 78.2 ± 25.1 min, p = 0.33). Compared with the standard group, the KODEX group significantly reduced the intraoperative X-ray exposure time (3.8 ± 0.5 vs. 19.3 ± 5.1 min, p < 0.05) and X-ray dose (23.6 ± 5.4 vs. 120.2 ± 38.3 mGy, p < 0.05). There were no significant differences in atrial impedance (643.0 ± 98.8 vs. 591.5 ± 92.1 Ω, p = 0.09), atrial sensing (2.9 ± 0.8 vs. 2.5 ± 0.8 mV, p = 0.08), ventricular sensing (12.8 ± 2.4 vs. 13.3 ± 3.3 mV, p = 0.63),atrial pacing threshold (1.0 ± 0.2 vs. 1.0 ± 0.1 V/0.4 ms, p = 0.81) and ventricular pacing threshold (1.0 ± 0.2 vs. 0.9 ± 0.1 V/0.4 ms, p = 0.63) between two groups, There were statistical differences in ventricular impedance (640.0 ± 80.3 vs. 702.0 ± 86.1 Ω, p < 0.05). There was no statistical significance in pacing parameters between the two groups at 6 months after procedure (p > 0.05). During the 6-months follow-up period, no adverse events occurred in the two groups. It can be concluded that KODEX-EPD can safely guide His bundle branch pacing lead implantation with reduced fluoroscopic time and dose without lengthening the procedure time.
Population structure and genetic diversity of the endangered fish black shinner Pseudopungtungia nigra (Cyprinidae) in Korea: a wild and restoration population
Authors: Kim Kang-Rae , Kwak Yeong-Ho , Sung Mu-Sung , Cho Seong-Jang , Bang In-Chul 
Published: June 2023

AbstractThe black shinner Pseudopungtungia nigra Mori, 1935 is an endangered fish endemic to Korea. It lives in the narrow basin of the Geumgang River, Mangyeonggang River, and Ungcheoncheon Stream, which flow into the West Sea of Korea. One population of P. nigra in Ungcheoncheon Stream has been locally exterminated once; it is now inhabiting the upper reaches of the dam through a restoration program. Efforts to identify and understand the genetic structure of these populations are important for conservation planning. Here, we analyzed genetic diversity using 21 microsatellite markers for 9 populations. The mean number of alleles ranged from 4.4 to 8.1, mean allelic richness ranged from 4.6 to 7.8, mean observed heterozygosity ranged from 0.519 to 0.702, and mean expected heterozygosity ranged from 0.540 to 0.763. All groups had recent and historical bottlenecks (P < 0.05, M-ratio < 0.68). Three groups [YD (2019), OC and UC] had significant inbreeding index values, suggesting that they were engaged in inbreeding. We observed a moderate level of genetic differentiation between MG and the rest of the population (FST = 0.135 to 0.168, P < 0.05). The genetic structure exhibited a fitting constant K = 2, along with separation between MG and the remaining populations. With respect to genetic flow, YD (2019), OC, CG, and ND shifted to the UC population (0.263 to 0.278). The genetic flow of each population was transferred only within the population; there was no gene flow among populations, except for the Ungcheoncheon Stream population. This study shows that the Ungcheoncheon Stream population needs conservation efforts to increase its genetic diversity, and the Geumgang River populations needs a conservation plan that considers the possibility of conservation and evolution through gene exchange among the populations.
Extremely high relative growth rate makes the cabbage white, Pieris rapae, a global pest with highly abundant and migratory nature
Authors: Konno Kotaro 
Published: June 2023

AbstractThe small cabbage white butterfly, Pieris rapae, is an extraordinarily abundant migratory pest of cabbage that causes severe damage worldwide without known reasons. I here show that the average relative growth rate (RGR: the ratio of the daily increase of biomass to total biomass) of herbivore (Gh; an indicator of the growth speed of herbivore) of P. rapae on cabbage during the larval period is larger by far than those of all other insect–plant pairs tested. It exceeds 1.15 (/day),—meaning that the biomass more than doubles each day—compared to 0.1–0.7 for most insect–plant pairs, including that of Pieris melete, a sibling of P. rapae which never becomes a pest of cabbage. My data further showed the RGR in the larval stage (larval Gh), positively correlates with abundance and/or migratoriness of insect herbivores. These results together with my mathematical food web model suggest that the extraordinarily high larval Gh of P. rapae is the primary reason for its ubiquitously severe pest status accompanied with its abundance and migratoriness, and that the RGR of herbivores, Gh, characterizing the plant–herbivore interface at the bottom of the food webs is an important factor affecting whole ecosystems, including animal abundance, fauna size, plant damage levels, competitiveness among herbivorous species, determination of hostplant, invasiveness, and the evolution of animal traits involved in the so-called r/K strategy, such as migratoriness. Knowledge about Gh will be crucial to controlling pests and improving the negative effects of human activity on ecosystems including faunal decline (or defaunation).
Microgravity induces overconfidence in perceptual decision-making
Authors: Loued-Khenissi Leyla , Pfeiffer Christian , Saxena Rupal , Adarsh Shivam , Scaramuzza Davide 
Published: June 2023

AbstractDoes gravity affect decision-making? This question comes into sharp focus as plans for interplanetary human space missions solidify. In the framework of Bayesian brain theories, gravity encapsulates a strong prior, anchoring agents to a reference frame via the vestibular system, informing their decisions and possibly their integration of uncertainty. What happens when such a strong prior is altered? We address this question using a self-motion estimation task in a space analog environment under conditions of altered gravity. Two participants were cast as remote drone operators orbiting Mars in a virtual reality environment on board a parabolic flight, where both hyper- and microgravity conditions were induced. From a first-person perspective, participants viewed a drone exiting a cave and had to first predict a collision and then provide a confidence estimate of their response. We evoked uncertainty in the task by manipulating the motion’s trajectory angle. Post-decision subjective confidence reports were negatively predicted by stimulus uncertainty, as expected. Uncertainty alone did not impact overt behavioral responses (performance, choice) differentially across gravity conditions. However microgravity predicted higher subjective confidence, especially in interaction with stimulus uncertainty. These results suggest that variables relating to uncertainty affect decision-making distinctly in microgravity, highlighting the possible need for automatized, compensatory mechanisms when considering human factors in space research.
Age of the magma chamber and its physicochemical state under Elbrus Greater Caucasus, Russia using zircon petrochronology and modeling insights
Authors: Bindeman I. N. , Melnik O. E. , Guillong M. , Utkin I. S. , Wotzlaw J.-F. , Schmitt A. K. , Stern R. A. 
Published: June 2023

AbstractMount Elbrus, Europe's tallest and largely glaciated volcano, is made of silicic lavas and is known for Holocene eruptions, but the size and state of its magma chamber remain poorly constrained. We report high spatial resolution U–Th–Pb zircon ages, co-registered with oxygen and hafnium isotopic values, span ~ 0.6 Ma in each lava, documenting magmatic initiation that forms the current edifice. The best-fit thermochemical modeling constrains magmatic fluxes at 1.2 km3/1000 year by hot (900 °C), initially zircon-undersaturated dacite into a vertically extensive magma body since ~ 0.6 Ma, whereas a volcanic episode with eruptible magma only extends over the past 0.2 Ma, matching the age of oldest lavas. Simulations explain the total magma volume of ~ 180 km3, temporally oscillating δ18O and εHf values, and a wide range of zircon age distributions in each sample. These data provide insights into the current state (~ 200 km3 of melt in a vertically extensive system) and the potential for future activity of Elbrus calling for much-needed seismic imaging. Similar zircon records worldwide require continuous intrusive activity by magmatic accretion of silicic magmas generated at depths, and that zircon ages do not reflect eruption ages but predate them by ~ 103 to 105 years reflecting protracted dissolution–crystallization histories.
Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits
Authors: Janky Kristen , Steyger Peter S. 
Published: June 2023

Purpose:
Acquired vestibulotoxicity from hospital-prescribed medications such as aminoglycoside antibiotics affects as many as 40,000 people each year in North America. However, there are no current federally approved drugs to prevent or treat the debilitating and permanent loss of vestibular function caused by bactericidal aminoglycoside antibiotics. This review will cover our current understanding of the impact of, and mechanisms underlying, aminoglycoside-induced vestibulotoxicity and highlight the gaps in our knowledge that remain.

Conclusions:
Aminoglycoside-induced vestibular deficits have long-term impacts on patients across the lifespan. Additionally, the prevalence of aminoglycoside-induced vestibulotoxicity appears to be greater than cochleotoxicity. Thus, monitoring for vestibulotoxicity should be independent of auditory monitoring and encompass patients of all ages from young children to older adults before, during, and after aminoglycoside therapy.
Frequency analysis of the hybrid δ Sct-γ Dor star CoRoT-102314644
Authors: Sánchez Arias J. P. , Creevey O. L. , Chapellier E. , Pichon B. 
Published: June 2023

Context. Observations from space missions allowed significant progress due to the absence of atmospheric noise contributions and having uninterrupted data sets. This has been extremely beneficial in asteroseismology because many oscillation frequencies, not observable from the ground, can be detected. One example of this success is the large number of hybrid δ Sct-γ Dor stars discovered. These stars have radial and non-radial p and g modes simultaneously excited, allowing us to probe both the external and near-to-core layers.
Aims. We aim to analyse the light curve of the hybrid δ Sct-γ Dor star CoRoT ID 102314644 and characterise its frequency spectrum. Using the detected frequencies, we intend to perform an initial interpretation developing stellar models.
Methods. The frequency analysis was obtained with a classical Fourier analysis. A detailed analysis of the individual frequencies is performed using phase diagrams and other light curve characteristics. Initial stellar modelling was performed using the Cesam2k and the GYRE code.
Results. We detected 29 γ Dor type frequencies in the [0.32 − 3.66] c/d range and a series of six equidistant periods with a mean period spacing of ΔΠ = 1612 s. In the δ Sct domain, we found 38 frequencies in the [8.63 − 24.73] c/d range and a quintuplet centred on the frequency p1 = 11.39 c/d, which suggests a rotational period of 3.06 d. The frequency analysis suggests the presence of spots. Nevertheless, we could not dismiss the possibility of a binary system. The initial modelling of the frequency data allowed us to refine its astrophysical parameters.
Conclusions. The observed period spacing, a p-mode quintuplet, the possible rotation period, and the analysis of the individual frequencies impose significant constraints on our understanding of differential rotation and magnetic fields operating in A–F-type stars. Nevertheless, it is fundamental to accompany photometric data with spectroscopic measurements to distinguish variations between surface activity from a companion.