bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of plasma modified pyrolytic carbon black in improving mechanical properties of natural rubber composite
Authors: Feng Xincong , Dong Hailing , Yang Huiru , Yao Huidan , Hu Shanjun , Zhao Hongying , Zhao Shugao , Sun Chong 
Published: May 2023

AbstractIn this work, the Argon (Ar) plasma technology is adopted for pyrolytic carbon black (CBp) modification and the N330/Modified‐CBp (MCBp) hybrid is then incorporated into the Natural Rubber (NR) matrix. Compared with CBp, the MCBp has smaller particle size, lower ash content, higher specific surface area, and surface activity based on the results of laser diffraction method, transmission electron microscope (TEM), thermogravimetric analysis, gas sorption analysis (Nitrogen), acetone solvent, and X‐ray photoelectron spectroscopy. Among them, Dv (90) is found to have reduced by 20% while the specific surface area increased by 4%. According to the bound rubber content experiments, the equilibrium swelling experiments as well as the temperature and strain sweeps, the bound rubber content, filler‐filler bond strength, and cross‐linking density of NR/N330/MCBp are all superior to those of NR/N330/CBp, resulting in an outstanding comprehensive performance of NR/N330/MCBp composite. In particular, the 300% modulus and the tear strength rise by 43% and 14% respectively, surpassing even the system filled with N330. Finally, the mechanism of mechanical properties improvement in the NR/N330/MCBp composite is proposed: the strong filler‐filler bond is formed between the MCBp and N330 aggregates via molecular chains, and they are anchored on the MCBp and absorbed on the N330 simultaneously.
Double sodium channel mutation, I265T/L1014F, is possibly related to pyrethroid‐resistant in Thrips palmi
Authors: Wu Jiantao , Yuan Linlin , Jin Haifeng , Zhang Kun , Li Fen , Wu Shaoying 
Published: May 2023

AbstractThrips palmi Karny (Thysanoptera: Thripidae) can harm a variety of agricultural crops and transmit plant viruses, causing heavy economic losses. In the Hainan province of China, pyrethroids were sprayed widely to control T. palmi, which leaded to resistance to pyrethroids in T. palmi. The bioassay has shown that the resistance ratio of T. palmi to pyrethroids increases annually. Resistance ratio to λ‐cyhalothrin has increased from 10.711 to 23.321 and to cypermethrin has increased from 5.507 to 23.051 for 3 years, 2020−2022. The double mutation (I265T/L1014F) was identified from the field strain for the first time, which were located in the domains I and II of the voltage‐gated sodium channel of T. palmi, respectively. The double mutation is probably the reason for the higher resistance of T. palmi in Hainan. The frequencies of the double mutation were 53.33% in HN2020, 70.00% in HN2021, and 96.67% in HN2022. Results indicated that T. palmi had developed different degrees of resistance to pyrethroids in Hainan. This study provides theoretical guidance for the use of insecticides in the field control of thrips.
Molecular insights of KMT2D and clinical aspects of Kabuki syndrome type 1
Authors: Golden Carly S. , Williams Saylor , Serrano Maria A. 
Published: May 2023

AbstractBackgroundKabuki syndrome type 1 (KS1), a rare multisystem congenital disorder, presents with characteristic facial features, intellectual disability, persistent fetal fingertip pads, skeletal abnormalities, and postnatal growth delays. KS1 results from pathogenic variants in the KMT2D gene, which encodes a histone methyltransferase protein involved in chromatin remodeling, promoter and enhancer regulation, and scaffold formation during early development. KMT2D also mediates cell signaling pathways, responding to external stimuli and organizing effector protein assembly. Research on KMT2D's molecular mechanisms in KS1 has primarily focused on its histone methyltransferase activity, leaving a gap in understanding the methyltransferase‐independent roles in KS1 clinical manifestations.MethodsThis scoping review examines KMT2D's role in gene expression regulation across various species, cell types, and contexts. We analyzed human pathogenic KMT2D variants using publicly available databases and compared them to research organism models of KS1. We also conducted a systematic search of healthcare and governmental databases for clinical trials, studies, and therapeutic approaches.ResultsOur review highlights KMT2D's critical roles beyond methyltransferase activity in diverse cellular contexts and conditions. We identified six distinct groups of KMT2D as a cell signaling mediator, including evidence of methyltransferase‐dependent and ‐independent activity. A comprehensive search of the literature, clinical databases, and public registries emphasizes the need for basic research on KMT2D's functional complexity and longitudinal studies of KS1 patients to establish objective outcome measurements for therapeutic development.ConclusionWe discuss how KMT2D's role in translating external cellular communication can partly explain the clinical heterogeneity observed in KS1 patients. Additionally, we summarize the current molecular diagnostic approaches and clinical trials targeting KS1. This review is a resource for patient advocacy groups, researchers, and physicians to support KS1 diagnosis and therapeutic development.
Exact sample size determination for a single Poisson random sample
Authors: Gentile Susanna , Sambucini Valeria 
Published: May 2023

AbstractClassical power analysis for sample size determination is typically performed in clinical trials. A “hybrid” classical Bayesian or a “fully Bayesian” approach can be alternatively used in order to add flexibility to the design assumptions needed at the planning stage of the study and to explicitly incorporate prior information in the procedure. In this paper, we exploit and compare these approaches to obtain the optimal sample size of a single‐arm trial based on Poisson data. We adopt exact methods to establish the rejection of the null hypothesis within a frequentist or a Bayesian perspective and suggest the use of a conservative criterion for sample size determination that accounts for the not strictly monotonic behavior of the power function in the presence of discrete data. A Shiny web app in R has been developed to provide a user‐friendly interface to easily compute the optimal sample size according to the proposed criteria and to assure the reproducibility of the results.
HHV8 and EBV‐negative primary effusion‐based lymphoma: A case report of a new provisional entity and review of literature
Authors: Canelo‐Vilaseca Marta , Tapia Gustavo , Orna Elisa , Sorigué Marc , Granada Isabel , Palomar‐Muñoz Azahara , Castillo Ana , Grau Javier , Mesa Alba , Ribera Josep‐Maria , Sancho Juan‐Manuel , Navarro José‐Tomás 
Published: May 2023

Key Clinical MessageHHV8‐ and EBV‐negative primary effusion lymphoma is an extremely rare neoplasm involving body cavities without detectable tumor mass. It usually presents in elderly patients without known immunodeficiency. Compared to primary effusion lymphoma, it has a better prognosis.Primary effusion lymphoma (PEL) is a rare non‐Hodgkin lymphoma confined exclusively to body cavities without detectable tumor masses. The term PEL‐like is an entity similar to PEL in clinical presentation but without relation to human herpesvirus 8 (HHV8). We report a case of HHV8‐ and EBV‐negative primary effusion‐based lymphoma.
Orbital cellulitis complicated with subperiosteal abscess following post‐nasopharyngeal swab for COVID‐19: A case report
Authors: Abdul‐Kadir Mohd‐Asyraaf , Rosli Abdul‐Hadi 
Published: May 2023

Key Clinical MessageThe nasopharyngeal swab for COVID‐19 is associated with low risks of severe complications, but it is important to consider the patient's medical history and anatomy of the nasal cavity to ensure safety and accuracy of the test. Orbital complications can occur up to 85% secondary to acute sinusitis, and prompt treatments are crucial, particularly in the pediatric group. A conservative approach is effective for subperiosteal abscess if certain criteria are met, and it is not an absolute indication for immediate surgical intervention. However, timely management of orbital cellulitis is essential for better outcomes.AbstractPre‐septal and orbital cellulitis are more commonly seen in children than in adults. The incidence of pediatric orbital cellulitis is 1.6 in 100,000. The impact of COVID‐19 has led to the increasing practice of nasopharyngeal swab surveillance. We presented a case of rare pediatric orbital cellulitis complicated with subperiosteal abscess secondary to severe acute sinusitis following a nasopharyngeal swab. A 4‐year‐old boy was brought in by his mother with increasing painful left eye swelling and redness. Three days prior, the patient developed a fever and mild rhinitis with loss of appetite which raised concerns about COVID‐19. He had a nasopharyngeal swab on that same day and tested negative. Clinically, there was marked erythematous and tender periorbital and facial oedema involving the left nasal bridge, maxilla extended to the left upper lip with a deviation of the left nasal tip contralaterally. Computed tomography confirmed left orbital cellulitis with left eye proptosis, fullness of left maxillary and ethmoidal sinuses and left subperiosteal abscess. The patient received empirical antibiotics and surgical intervention promptly and recovered well with improvements in ocular symptoms. The nasal swabbing techniques may vary among practitioners, and it is associated with extremely low risks of severe complications from 0.001% to 0.16%. Whether the swab had aggravated the underlying rhinitis or traumatized the turbinates leading to sinus drainage obstruction; a nasal swab may impose the risk of severe orbital infection in a susceptible pediatric patient. Any health practitioner conducting the nasal swab should be vigilant about this potential complication.
Fully Conjugated Benzyne‐Derived Three‐Dimensional Porous Organic Polymers
Authors: Ashirov Timur , Fritz Patrick W. , Lauber Yanic , Avalos Claudia E. , Coskun Ali 
Published: May 2023

AbstractPorous organic polymers (POPs) have gained tremendous attention owing to their chemical tunability, stability and high surface areas. Whereas there are several examples of fully conjugated two‐dimensional (2D) POPs, three‐dimensional (3D) ones are rather challenging to realize in the absence of structural templates. Herein, we report the base‐catalyzed direct synthesis of a fully conjugated 3D POPs, named benzyne‐derived polymers (BDPs), containing biphenylene and tetraphenylene moieties starting from a simple bisbenzyne precursor, which undergoes [2+2] and [2+2+2+2] cycloaddition reactions to form BDPs primarily composed of biphenylene and tetraphenylene moieties. The resulting polymers exhibited ultramicroporous structures with surface areas up to 544 m2 g−1 and very high CO2/N2 selectivities.
A Mild Synthesis of Aryl Triflates Enabling the Late‐Stage Modification of Drug Analogs and Complex Peptides
Authors: Schiesser Stefan , Ceklarz Joanna , Kollback Johanna , Borowiec Lucie , Fagerlund Julia , Vahdat Shakiba , Lindhagen Marika , Dwichandra Putra Okky 
Published: May 2023

AbstractWe report the discovery of a straightforward protocol to convert phenols into the corresponding aryl triflates using 1‐methyl‐3‐((trifluoromethyl)sulfonyl)‐1,3‐dihydro‐2H‐benzo[d]imidazol‐2‐one in the presence of a fluoride source. This novel reagent can be handled without any precautions to exclude air or moisture making this method highly convenient. The reactions generally show very clean conversions within only a few minutes at room temperature. The mild conditions allow the so far unprecedented O‐triflation of tyrosine in peptides bearing challenging side chains present for example in arginine and histidine including the late‐stage triflation of complex bioactive peptides. We show how aryl triflates – an interesting but so far underutilized group – can be used to optimize physicochemical and in vitro properties of compound series in medicinal chemistry. We believe that this method is highly attractive for applications in peptide functionalization as well as automated and medicinal chemistry.
Progress in reducing cancer mortality in the United States by congressional district, 1996–2003 to 2012–2020
Authors: Islami Farhad , Wiese Daniel , Marlow Emily C. , Kratzer Tyler B. , Massey Jason , Sung Hyuna , Jemal Ahmedin 
Published: May 2023

AbstractBackgroundUnited States cancer death rates have been steadily declining since the early 1990s, but information on disparities in progress against cancer mortality across congressional districts is lacking. This study examined trends in cancer death rates, overall and for lung, colorectal, female breast, and prostate cancer by congressional district.MethodsCounty level cancer death counts and population data from the National Center for Health Statistics were used to estimate relative change in age‐standardized cancer death rates from 1996–2003 to 2012–2020 by sex and congressional district.ResultsFrom 1996–2003 to 2012–2020, overall cancer death rates declined in every congressional district, with most congressional districts showing a 20%–45% decline among males and a 10%–40% decline among females. In general, the smallest percent of relative declines were found in the Midwest and Appalachia, whereas the largest declines were found in the South along the East Coast and the southern border. As a result, the highest cancer death rates generally shifted from congressional districts across the South in 1996–2003 to districts in the Midwest and central divisions of the South (including Appalachia) in 2012–2020. Death rates for lung, colorectal, female breast, and prostate cancers also declined in almost all congressional districts, although with some variation in relative changes and geographical patterns.ConclusionsProgress in reducing cancer death rates during the past 25 years considerably vary by congressional district, underscoring the need for strengthening existing and implementing new public health policies for broad and equitable application of proven interventions such as raising tax on tobacco and Medicaid expansion.
Gas Flow Sputtering of Pt/C Films and their Performance in Electrocatalytic Hydrogen Evolution Reaction
Authors: Bernsmeier Denis , Selve Sören , Nissen Jörg , Maticiuc Natalia , Ibaceta‐Jaña Josefa , Szyszka Bernd , Muydinov Ruslan 
Published: May 2023

AbstractA single step deposition technique of Pt/C films for electrocatalytic applications is presented. The hollow cathode gas flow sputtering (GFS) method allows a catalyst production within few minutes without further steps. The herein presented films consist of small Pt nanocrystals (2–5 nm) deposited in a matrix of nanocrystalline carbon. The films show a low and stable overpotential under acidic conditions in the hydrogen evolution reaction (HER). Relatively low Pt‐mass activity (<1 mA/μgPt) is attributed to the yet too high Pt‐content in the films. Another issue discovered in this work is a non‐graphitic state of carbon resulting in its high resistivity. Still, the GFS deposition technique providing by nature high deposition rates and a substance‐to‐material yield of 80–90 % is advantageous than other sputtering techniques and especially chemical methods in that sense. This technique is scalable to areas in the range of square meters and thus represents an attractive way to efficiently produce large‐scale cathode coatings for industrial electrolysers.
Soft Carbon as Cathode with High Rate Performance for Dual‐Ion Batteries via Fast PF6− Intercalation Improved by Surface Effect
Authors: Shen Yong‐Feng , Zhang Meng‐Meng , Yan Dong , Lv Jia‐He , Wu Tao , He Bin , Li Wen‐Cui 
Published: May 2023

AbstractDual‐ion battery is a new type of battery in which both anions and cations participate in the energy storage process. However, this unique battery configuration imposes high requirements on the cathode, which typically presents a poor rate performance due to the sluggish diffusion dynamics and intercalation reaction kinetics of anions. Herein, we report petroleum coke‐based soft carbon as the cathode for dual‐ion batteries, exhibiting a superior rate performance with a specific capacity of 96 mAh g−1 at a rate of 2 C and 72 mAh g−1 remained even at 50 C. In situ XRD and Raman demonstrate that the anions can directly form lower‐stage graphite intercalation compounds during the charge process owing to the surface effect, skipping the long evolutionary process from higher to lower stage, thus significantly improving the rate performance. This study highlights the impact of the surface effect and provides a promising perspective for dual‐ion batteries.
Indirect biomarkers of blood doping: A systematic review
Authors: Krumm Bastien , Saugy Jonas J. , Botrè Francesco , Donati Francesco , Faiss Raphael 
Published: May 2023

AbstractThe detection of blood doping represents a current major issue in sports and an ongoing challenge for antidoping research. Initially focusing on direct detection methods to identify a banned substance or its metabolites, the antidoping effort has been progressively complemented by indirect approaches. The longitudinal and individual monitoring of specific biomarkers aims to identify nonphysiological variations that may be related to doping practices. From this perspective, the identification of markers sensitive to erythropoiesis alteration is key in the screening of blood doping. The current Athlete Biological Passport implemented since 2009 is composed of 14 variables (including two primary markers, i.e., hemoglobin concentration and OFF score) for the hematological module to be used for indirect detection of blood doping. Nevertheless, research has continually proposed and investigated new markers sensitive to an alteration of the erythropoietic cascade and specific to blood doping. If multiple early markers have been identified (at the transcriptomic level) or developed directly in a diagnostics' kit (at a proteomic level), other target variables at the end of the erythropoietic process (linked with the red blood cell functions) may strengthen the hematological module in the future. Therefore, this review aims to provide a global systematic overview of the biomarkers considered to date in the indirect investigation of blood doping.
Ag/K2S2O8‐Mediated Direct Thiolation and Selenylation of Carbazoles
Authors: Yin Jin , Chen Peng , Miao Le‐Wei , Wang Jie , Jiang Yi‐Jun 
Published: May 2023

AbstractThe first direct and selective 3,6‐di‐thiolation and 3,6‐di‐selenylation of carbazoles using diaryl disulfides/diselenide as the sulfur/selenium source were demonstrated. This simple, general, and efficient method could deliver a wide range of 3,6‐di‐sulfenyl‐carbazoles and 3,6‐di‐selenyl‐carbazoles from readily available starting materials with high regioselectivity in an easily‐operated one‐step reaction via a Ag/K2S2O8‐mediated protocol.
Single cell metabolic phenome and genome via the ramanome technology platform: Precision medicine of infectious diseases at the ultimate precision?
Authors: Xu Jian , Zhang Jianzhong , Xu Yingchun , Tang Yi‐Wei , Ma Bo , Wu Yuzhang 
Published: May 2023

AbstractDue to the limitations of existing approaches, a rapid, sensitive, accurate, comprehensive, and generally applicable strategy to diagnose and treat bacterial and fungal infections remains a major challenge. Here, based on the ramanome technology platform, we propose a culture‐free, one cell resolution, phenome‐genome‐combined strategy called single‐cell identification, viability and vitality tests and source tracking (SCIVVS). For each cell directly extracted from a clinical specimen, the fingerprint region of the D2O‐probed single cell Raman spectrum (SCRS) enables species‐level identification based on a reference SCRS database of pathogen species, whereas the C‐D band accurately quantifies viability, metabolic vitality, phenotypic susceptibility to antimicrobials, and their intercellular heterogeneity. Moreover, to source track a cell, Raman‐activated cell sorting followed by sequencing or cultivation proceeds, producinging an indexed, high coverage genome assembly or a pure culture from precisely one pathogenic cell. Finally, an integrated SCIVVS workflow that features automated profiling and sorting of metabolic and morphological phenomes can complete the entire process in only a few hours. Because it resolves heterogeneity for both the metabolic phenome and genome, targets functions, can be automated, and is orders‐of‐magnitude faster while cost‐effective, SCIVVS is a new technological and data framework to diagnose and treat bacterial and fungal infections in various clinical and disease control settings.
Antiracist school counseling: A consensual qualitative study
Authors: Leigh‐Osroosh Katheryne T. , Clemons Krystal , Robertson Adrianne , Placeres Vanessa , Gay Jan , Lopez‐Perry Caroline , Mason Erin C. , Ieva Kara P. , Lane Erin M. D. , Saunders Rachel 
Published: May 2023

AbstractSchool counselors have a unique role as frontline advocates and change agents who work toward addressing systemic inequities within K‐12 education (Placeres et al., 2022). Racism is the systemic prioritization of Whiteness as the standard of humanness, success, and well‐being. School counselors are responsible for resisting racism in the support of the wellness of all students. This consensual qualitative study examined the question, what is antiracist school counseling? Four focus groups (N = 17) were conducted within the School Counseling Interest Network (SCIN), a subgroup of the Association for Counselor Education and Supervision (ACES). The resulting four domains, such as anti‐Blackness, knowledge, action, and responsibility, describe antiracist school counseling. Implications for counselor education, research, and practice are discussed.