bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature
Authors: Liu Linlin , Deng Xianbo , Guo Shuang , Yang Shouhua 
Published: September 2023

Abstract
Background
The locally advanced cervical cancer (LACC) of FIGO stage IB3-IIA2 is characterized by large local mass, poor prognosis and survival rate. Tumor response to neoadjuvant chemotherapy for LACC, utilized as a surrogate endpoint, is urgently needed to improve. Given that the antitumor immune response can be suppressed by programed death-1 axis, the treatment paradigm of neoadjuvant chemotherapy combined with immunotherapy has been explored as one of the prognostic treatments in a variety of solid carcinoma. So far, the application of sintilimab, a domestic immune checkpoint inhibitor, combined with neoadjuvant chemotherapy is still limited in LACC, especially in large lesions.

Case description
We present three postmenopausal women diagnosed with FIGO stage IB3-IIA2 cervical squamous cell carcinoma with lesions larger than 5 cm. Demographic, clinical, histopathological, laboratory and imaging data were record. At the completion of the neoadjuvant therapy with paclitaxel plus carboplatin combined with sintilimab, all patients underwent hysterectomy. After neoadjuvant treatment, a pathologic complete response in case 1 and partial responses in case 2 and case 3 were achieved, and neither patient showed any relapse during the follow-up period of 16 to 22 months.

Conclusions
This report provide evidence to support the combination of sintilimab with neoadjuvant chemotherapy in cervical cancer, which has yet to be validated in prospective studies. More clinical data are needed to verify the effectiveness of the combined regimens. This literature review also collected studies involving potential predictors of response to NACT and immunotherapy, which would be helpful in stratifying patients for future trials.
Vibration therapy to improve pain and function in patients with chronic low back pain: a systematic review and meta-analysis
Authors: Li Qiang , Liu Pan , Wang Zongbao , Li Xin 
Published: September 2023

Abstract
Background
Vibration therapy (VT), a treatment of musculoskeletal disorders, has been developed for clinical applications in the past decade. However, its effect on relieving chronic low back pain (CLBP) and improving lumbar function is still illusive, lacking sufficient evidence-based medical data.

Objective
This systematic review aimed to evaluate the efficacy of vibration therapy on pain and function in people with CLBP.

Methods
PubMed, Cochrane Library, Web of Science, Embase, CNKI, Wanfang Date, VIP, and CBM were applied to search for clinical randomized controlled trials (RCTs) on vibration therapy for people with CLBP. The electronic databases were searched from the establishment of the database until July 1, 2023. Two researchers assessed the quality of the included studies and extracted data. The outcome indicators included the pain intensity index, Oswestry dysfunction index (ODI) score, and Roland–Morris dysfunction questionnaire (RMDQ) score. GRADE was used to evaluate the certainty of evidence of each outcome indicator. The meta-analysis was conducted using RevMan 5.3 software.

Results
Fourteen papers met the inclusion criteria with 860 subjects (VT group n = 432 and control group n = 428). VT for patients with CLBP reduced the pain intensity index [SMD = − 0.71, 95% CI (− 1.02, − 0.39), I2 = 76%, P < 0.0001], the ODI score value [MD = − 4.24, 95% CI (− 8.10, − 0.38), I2 = 88%, P = 0.03], and the RMDQ score value [MD = − 2.21, 95% CI (− 3.41, − 1.01), I2 = 0%, P = 0.0003]. Subgroup analysis displayed that the pain intensity index was lower in the whole-body vibration (WBV) group than in the control group [SMD = − 0.49, 95% CI (− 0.79, − 0.19), I2 = 58%, P = 0.001] and the local vibration (LV) group [SMD = − 1.07, 95% CI (− 1.60, − 0.53), I2 = 76%, P < 0.0001]. The ODI scores in the WBV group were lower than those in the control group [MD = − 3.30, 95% CI (− 5.76, − 0.83), I2 = 36%, P = 0.009]. There was no statistically significant difference in ODI scores between the LV group and the control group [MD = − 5.78, 95% CI (− 16.23, 4.66), I2 = 97%, P = 0.28].

Conclusion
The data from this study suggest that VT can reduce pain and improve lumbar function in patients with CLBP. However, we still need to carefully interpret the results of this study, as the certainty of evidence was low, and the clinical relevance of the results is questionable. Further RCTs are needed in the future to ascertain this.
Impact of surgically placed radiopaque markers during aortic root surgery on facilitating secondary diagnostic and therapeutic interventions
Authors: Zimmer Emmanuel , Nucera Maria , Pingpoh Clarence , Yildiz Murat , Puiu Paul , Schoenhoff Florian , Czerny Martin , Siepe Matthias 
Published: September 2023

Abstract
Background
Implantation of radiopaque markers during aortic root surgery might possibly facilitate upcoming coronary angiography or transcatheter aortic valve implantation. Aim of this study was to report the impact of surgically placed radiopaque markers on procedural characteristics and on angiographic outcomes.

Methods
We retrospectively analyzed baseline characteristics, preoperative and postoperative data as well as procedural findings. In addition, a subgroup analysis of all patients who underwent coronary angiography after aortic root surgery was performed to report radiation time and contrast media used.

Results
A total of 469 patients underwent aortic root surgery between January 2008 and April 2020. Patients were divided into two groups: group w/ markers (n = 182) and group w/o markers (n = 287). A propensity score matching was performed resulting in a total of 28 patients w/ markers and 28 patients w/o markers. Aortic cross-clamp time did not differ statistically significantly between the group w/o markers and the group w/ markers (124.0 [96.0–150.0] versus 123.0 [110.0–149.0] min, p = 0.09). There was no increased probability for requirement of postoperative angiography in the group w/o markers compared to the group w/ markers (11.8% versus 15.4%, p = 0.27). There was no statistically significant difference in the radiation time 5.5 [3–6.5] versus 5 [2.5–7.5] min, p = 0.62) nor in the amount of contrast media used (85 [77.5–100] versus 80 [60–90] ml, p = 0.07).

Conclusions
Surgically placed radiopaque markers during aortic root surgery do not increase operative risk and have the potential for facilitating secondary diagnostic and therapeutic interventions.
Excellent agreement of Norwegian trauma registry data compared to corresponding data in electronic patient records
Authors: Naberezhneva N , Uleberg Oddvar , Dahlhaug M , Giil-Jensen V , Ringdal K G , Røise O 
Published: September 2023

Abstract
Background
The Norwegian Trauma Registry (NTR) is designed to monitor and improve the quality and outcome of trauma care delivered by Norwegian trauma hospitals. Patient care is evaluated through specific quality indicators, which are constructed of variables reported to the registry by certified registrars. Having high-quality data recorded in the registry is essential for the validity, trust and use of data. This study aims to perform a data quality check of a subset of core data elements in the registry by assessing agreement between data in the NTR and corresponding data in electronic patient records (EPRs).

Methods
We validated 49 of the 118 variables registered in the NTR by comparing those with the corresponding ones in electronic patient records for 180 patients with a trauma diagnosis admitted in 2019 at eight public hospitals. Agreement was quantified by calculating observed agreement, Cohen’s Kappa and Gwet’s first agreement coefficient (AC1) with 95% confidence intervals (CIs) for 27 nominal variables, quadratic weighted Cohen’s Kappa and Gwet’s second agreement coefficient (AC2) for five ordinal variables. For nine continuous, one date and seven time variables, we calculated intraclass correlation coefficient (ICC).

Results
Almost perfect agreement (AC1 /AC2/ ICC > 0.80) was observed for all examined variables. Nominal and ordinal variables showed Gwet’s agreement coefficients ranging from 0.85 (95% CI: 0.79–0.91) to 1.00 (95% CI: 1.00–1.00). For continuous and time variables there were detected high values of intraclass correlation coefficients (ICC) between 0.88 (95% CI: 0.83–0.91) and 1.00 (CI 95%: 1.00–1.00). While missing values in both the NTR and EPRs were in general negligeable, we found a substantial amount of missing registrations for a continuous “Base excess” in the NTR. For some of the time variables missing values both in the NTR and EPRs were high.

Conclusion
All tested variables in the Norwegian Trauma Registry displayed excellent agreement with the corresponding variables in electronic patient records. Variables in the registry that showed missing data need further examination.
Facile synthesis of MOF-derived N doped ZnO/C nanoparticles and its adsorption activity toward dye removal
Authors: Abas Khadiga Mohamed , Al Kiey Sherief A. 
Published: September 2023

AbstractMetal–organic framework (MOF)-derived materials have gained an increasing interest and showed potential adsorption features in numerous applications. Significant attempts have been performed to boost the structure, functionality, surface area and porosity in addition to adsorption performance of MOF-derived carbon nanoparticles. Here, nitrogen-doped ZnO/carbon nanoparticles were synthesized by directly pyrolysis of Zn based metal organic framework (ZIF-8) in a nitrogen atmosphere at two different temperatures (600 and 800 °C), followed by chemical impregnation with ZnCl2 solution with ratio (10:1) wt/wt, and thermal activation at 500 °C for 1 h. SEM, TEM, XPS, nitrogen adsorption–desorption method, and TGA characterization techniques were employed to investigate the morphology and structure characteristics. Then, thorough analysis of N doped ZnO/C-(600 and 800), adsorption capacity to remove Remazol brilliant blue reactive (RBBR) dye from aqueous phase was conducted. At room temperature, the porous N doped ZnO/C with high surface area attained a maximum adsorption capacity about 49.3 mg/g and demonstrated a strong adsorption capacity toward RBBR dye. The insights of kinetic, thermodynamic and adsorption isotherm studies of the as-demonstrated samples open up more discussion for MOFs-derived carbon adsorbents for wastewater treatment.
Conflict of interest and risk of bias in systematic reviews on methylphenidate for attention-deficit hyperactivity disorder: a cross-sectional study
Authors: Snellman Alexandra , Carlberg Stella , Olsson Louise 
Published: September 2023

Abstract
Background
Systematic reviews (SRs) are pivotal to evidence-based medicine, yet there is limited research on conflicts of interest in SRs. Our aim was to investigate financial conflicts of interest and risk of bias (RoB) in SRs of a well-defined clinical topic.

Methods
A librarian searched Medline, Cochrane Library, Embase, and PsycINFO for SRs investigating the effect of methylphenidate on ADHD in December 2020. The selection process adhered to the PRISMA guidelines. Two blinded reviewers independently searched open websites, including other publications, for information on financial conflicts of interest of all authors of the included SRs. A time limit of 3 years before or after the index SR was adopted. Declarations on conflict of interest were extracted from the included SRs for comparison. ROBIS was used for RoB assessment.

Results
Out of 44 SRs included, 15 (34%) declared conflict of interest, 27 (61%) did not, and a declaration of conflict of interest was missing for 2 (5%). On open websites, conflict of interest was found for at least one author of 23 (52%) SRs: disclosed in 15 (34%) and not disclosed in 8 (18%) SRs.
Seven (16%) SRs had low, 36 (82%) had high, and 1 (2%) had unclear RoB. Among SRs with financial conflict of interest found in open sources, 6/22 (27%) had low RoB compared to 1/21 (5%) if no such conflict of interest was identified. Among SRs with financial conflict of interest identified, 1/6 (17%) at low RoB did not disclose their conflict of interest, whereas the corresponding proportion among SRs at high RoB was 7/16 (44%).
Eight (18%) SRs presented conflict of interest disclosed in the included primary studies. Four of them (50%) had low RoB, compared to 3/36 (8%) for SRs not reporting on this aspect.

Conclusion
Financial conflict of interest was underreported in 18% of the SRs using our reference standard, and overall it was present for every second SR. This group embraced both SRs at low RoB disclosing conflict of interest and SRs at high RoB not disclosing their conflict of interest. Further studies to explore this heterogeneity are warranted.
Unplanned admissions after day-case surgery in an Italian third-level pediatric hospital: a retrospective study
Authors: Vittori Alessandro , Tritapepe Luigi , Chiusolo Fabrizio , Rossetti Emanuele , Cascella Marco , Petrucci Emiliano , Pedone Roberto , Marinangeli Franco , Francia Elisa , Mascilini Ilaria , Marchetti Giuliano , Picardo Sergio Giuseppe 
Published: September 2023

Abstract
Background
Increasing procedures in day-case surgery can mitigate the costs of health service, without reducing safety and quality standards. The Ospedale Pediatrico Bambino Gesù has adopted an educational program for healthcare personnel and patients’ families to increase the number of day-case surgery procedures performed without reducing the level of safety. The unplanned admission rate after day-case surgery can be a quality benchmark for pediatric day-case surgery, and in literature, there are no Italian data.

Methods
We made a retrospective analysis of the hospital database and focused on children requiring unplanned admission to the central venue of the hospital for the night. The audit covered the period from September 2012 to April 2018.

Results
We performed general anesthesia for 8826 procedures (urology 33.60%, plastic surgery 30.87%, general surgery 17.44%, dermatology 11.66%, dentistry 3.16%, orthopedics 1.64%, digestive endoscopy 1.63%). Unplanned admission for anesthetic reasons resulted in two cases: one case of syncope and one case of vomit (0.023% rate). No one major complication.

Conclusions
Good quality of patient selection, the safety of the structure, family education, and an efficient organizational model combined with an educational program for anesthesiologists can improve the safety of anesthesia for day-case surgery.
TCAP gene is not a common cause of cardiomyopathy in Iranian patients
Authors: Alaei Zahra , Zamani Nasrin , Rabbani Bahareh , Mahdieh Nejat 
Published: September 2023

Abstract
Background
Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are the most frequent cardiomyopathies that cause acute heart failure and sudden cardiac death. Previous genetic reports have shown that pathogenic variants of genes encoding Z-disc components such as telethonin protein (TCAP) are the primary cause of DCM and HCM.

Methods
This study was the first investigation on the TCAP gene among the Iranian cardiomyopathies population wherein the TCAP gene was analyzed in 40 unrelated patients (17 females and 23 males) who were clinically diagnosed with HCM and DCM. In addition, we conducted a thorough review of all published articles and the databases that were the first to report novel pathogenic or likely pathogenic variants the in TCAP gene.

Results
In the cohort of this study, we identified only one intronic variant c.111-42G > A in one of the HCM patients that were predicted as polymorphism by in-silico analysis. Moreover, a total of 44 variants were reported for the TCAP gene in the literature where a majority of mutations were found to be missense. Pathogenic mutations in TCAP may cause diseases including limb-girdle muscular dystrophy 2G (LGMD-2G), DCM, HCM, intestinal pseudo-obstruction, and telethonin deficiency. However, a large number of affected patients were clinically diagnosed with limb-girdle 2G compared to other presenting phenotypes.

Discussion
These findings suggest that the TCAP gene pathogenic mutations might not be a common cause of cardiomyopathies among Iranian patients. These gene disease-causing mutations may cause various manifestations, but it has a high prevalence among LGMD-2G, HCM, and DCM patients.
Lineage-specific symbionts mediate differential coral responses to thermal stress
Authors: Wang Chenying , Zheng Xinqing , Kvitt Hagit , Sheng Huaxia , Sun Danye , Niu Gaofeng , Tchernov Dan , Shi Tuo 
Published: September 2023

Abstract
Background
Ocean warming is a leading cause of increasing episodes of coral bleaching, the dissociation between coral hosts and their dinoflagellate algal symbionts in the family Symbiodiniaceae. While the diversity and flexibility of Symbiodiniaceae is presumably responsible for variations in coral response to physical stressors such as elevated temperature, there is little data directly comparing physiological performance that accounts for symbiont identity associated with the same coral host species. Here, using Pocillopora damicornis harboring genotypically distinct Symbiodiniaceae strains, we examined the physiological responses of the coral holobiont and the dynamics of symbiont community change under thermal stress in a laboratory-controlled experiment.

Results
We found that P. damicornis dominated with symbionts of metahaplotype D1-D4-D6 in the genus Durusdinium (i.e., PdD holobiont) was more robust to thermal stress than its counterpart with symbionts of metahaplotype C42-C1-C1b-C1c in the genus Cladocopium (i.e., PdC holobiont). Under ambient temperature, however, the thermally sensitive Cladocopium spp. exhibited higher photosynthetic efficiency and translocated more fixed carbon to the host, likely facilitating faster coral growth and calcification. Moreover, we observed a thermally induced increase in Durusdinium proportion in the PdC holobiont; however, this “symbiont shuffling” in the background was overwhelmed by the overall Cladocopium dominance, which coincided with faster coral bleaching and reduced calcification.

Conclusions
These findings support that lineage-specific symbiont dominance is a driver of distinct coral responses to thermal stress. In addition, we found that “symbiont shuffling” may begin with stress-forced, subtle changes in the rare biosphere to eventually trade off growth for increased resilience. Furthermore, the flexibility in corals’ association with thermally tolerant symbiont lineages to adapt or acclimatize to future warming oceans should be viewed with conservative optimism as the current rate of environmental changes may outpace the evolutionary capabilities of corals.
Cochran’s Q test for analyzing categorical data under uncertainty
Authors: Aslam Muhammad 
Published: September 2023

Abstract
Motivation
The Cochran test, also known as Cochran’s Q test, is a statistical procedure used to assess the consistency of proportions across multiple groups in a dichotomous dataset

Description
This paper introduces a modified version of Cochran’s Q test using neutrosophic statistics to handle uncertainty in practical situations. The neutrosophic Cochran’s Q test determines whether the proportions of a specific outcome are consistent across different groups, considering both determinate and indeterminate parts.

Results
An application of the proposed test is presented using production data to assess the capabilities of machines during different days of the week. The comparative study demonstrates the advantages of the proposed test over the classical Cochran’s Q test, providing insights into the degree of indeterminacy and enhancing decision-making in uncertain scenarios.

Conclusion
This study introduces a modified version of the Cochran test, utilizing neutrosophic statistics to address uncertainty in practical scenarios. The neutrosophic Cochran’s Q test effectively assesses the consistency of outcome proportions across various groups, accounting for both determinate and indeterminate factors. The application of this novel approach to machine capabilities assessment, based on production data collected over different days of the week, unveils its superiority over the traditional Cochran’s Q test. This superiority is reflected in the insights it offers into the degree of indeterminacy, thereby enhancing decision-making in contexts marked by uncertainty. The simulation study further underscores the critical role of indeterminacy in affecting test statistics and decision outcomes, highlighting the significance of the proposed method in capturing real-world complexities. In essence, the neutrosophic Cochran’s Q test presents a refined and pragmatic tool for addressing the uncertainties inherent in diverse datasets, rendering it invaluable in practical decision-making scenarios.
Contrastive self-supervised representation learning framework for metal surface defect detection
Authors: Zabin Mahe , Kabir Anika Nahian Binte , Kabir Muhammad Khubayeeb , Choi Ho-Jin , Uddin Jia 
Published: September 2023

AbstractAutomated detection of defects on metal surfaces is crucial for ensuring quality control. However, the scarcity of labeled datasets for emerging target defects poses a significant obstacle. This study proposes a self-supervised representation-learning model that effectively addresses this limitation by leveraging both labeled and unlabeled data. The proposed model was developed based on a contrastive learning framework, supported by an augmentation pipeline and a lightweight convolutional encoder. The effectiveness of the proposed approach for representation learning was evaluated using an unlabeled pretraining dataset created from three benchmark datasets. Furthermore, the performance of the proposed model was validated using the NEU metal surface-defect dataset. The results revealed that the proposed method achieved a classification accuracy of 97.78%, even with fewer trainable parameters than the benchmark models. Overall, the proposed model effectively extracted meaningful representations from unlabeled image data and can be employed in downstream tasks for steel defect classification to improve quality control and reduce inspection costs.
Deep learning-based lung sound analysis for intelligent stethoscope
Authors: Huang Dong-Min , Huang Jia , Qiao Kun , Zhong Nan-Shan , Lu Hong-Zhou , Wang Wen-Jin 
Published: September 2023

AbstractAuscultation is crucial for the diagnosis of respiratory system diseases. However, traditional stethoscopes have inherent limitations, such as inter-listener variability and subjectivity, and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in telemedicine. The emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and education. On this basis, machine learning, particularly deep learning, enables the fully-automatic analysis of lung sounds that may pave the way for intelligent stethoscopes. This review thus aims to provide a comprehensive overview of deep learning algorithms used for lung sound analysis to emphasize the significance of artificial intelligence (AI) in this field. We focus on each component of deep learning-based lung sound analysis systems, including the task categories, public datasets, denoising methods, and, most importantly, existing deep learning methods, i.e., the state-of-the-art approaches to convert lung sounds into two-dimensional (2D) spectrograms and use convolutional neural networks for the end-to-end recognition of respiratory diseases or abnormal lung sounds. Additionally, this review highlights current challenges in this field, including the variety of devices, noise sensitivity, and poor interpretability of deep models. To address the poor reproducibility and variety of deep learning in this field, this review also provides a scalable and flexible open-source framework that aims to standardize the algorithmic workflow and provide a solid basis for replication and future extension:https://github.com/contactless-healthcare/Deep-Learning-for-Lung-Sound-Analysis.