bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of humoral and cellular immune responses in hematologic diseases following completed vaccination protocol with BBIBP-CorV, or AZD1222, or BNT162b2 vaccines against SARS-CoV-2
Authors: Szabó Enikő , Modok Szabolcs , Rónaszéki Benedek , Faragó Anna , Gémes Nikolett , Nagy Lajos I. , Hackler László , Farkas Katalin , Neuperger Patrícia , Balog József Á. , Balog Attila , Puskás László G. , Szebeni Gabor J. 
Published: July 2023

BackgroundVaccination has proven the potential to control the COVID-19 pandemic worldwide. Although recent evidence suggests a poor humoral response against SARS-CoV-2 in vaccinated hematological disease (HD) patients, data on vaccination in these patients is limited with the comparison of mRNA-based, vector-based or inactivated virus-based vaccines.MethodsForty-nine HD patients and 46 healthy controls (HCs) were enrolled who received two-doses complete vaccination with BNT162b2, or AZD1222, or BBIBP-CorV, respectively. The antibodies reactive to the receptor binding domain of spike protein of SARS-CoV-2 were assayed by Siemens ADVIA Centaur assay. The reactive cellular immunity was assayed by flow cytometry. The PBMCs were reactivated with SARS-CoV-2 antigens and the production of activation-induced markers (TNF-α, IFN-γ, CD40L) was measured in CD4+ or CD8+ T-cells ex vivo.ResultsThe anti-RBD IgG level was the highest upon BNT162b2 vaccination in HDs (1264 BAU/mL) vs. HCs (1325 BAU/mL) among the studied groups. The BBIBP-CorV vaccination in HDs (339.8 BAU/mL ***p &lt; 0.001) and AZD1222 in HDs (669.9 BAU/mL *p &lt; 0.05) resulted in weaker antibody response vs. BNT162b2 in HCs. The response rate of IgG production of HC vs. HD patients above the diagnostic cut-off value was 100% vs. 72% for the mRNA-based BNT162b2 vaccine; 93% vs. 56% for the vector-based AZD1222, or 69% vs. 33% for the inactivated vaccine BBIBP-CorV, respectively. Cases that underwent the anti-CD20 therapy resulted in significantly weaker (**p &lt; 0.01) anti-RBD IgG level (302 BAU/mL) than without CD20 blocking in the HD group (928 BAU/mL). The response rates of CD4+ TNF-α+, CD4+ IFN-γ+, or CD4+ CD40L+ cases were lower in HDs vs. HCs in all vaccine groups. However, the BBIBP-CorV vaccine resulted the highest CD4+ TNF-α and CD4+ IFN-γ+ T-cell mediated immunity in the HD group.ConclusionWe have demonstrated a significant weaker overall response to vaccines in the immunologically impaired HD population vs. HCs regardless of vaccine type. Although, the humoral immune activity against SARS-CoV-2 can be highly evoked by mRNA-based BNT162b2 vaccination compared to vector-based AZD1222 vaccine, or inactivated virus vaccine BBIBP-CorV, whereas the CD4+ T-cell mediated cellular activity was highest in HDs vaccinated with BBIBP-CorV.
Dose–response relationship between multiple trace elements and risk of all-cause mortality: a prospective cohort study
Authors: Zhao Shaohua , Wang Shaohua , Yang Xiaorong , Shen Lin 
Published: July 2023

ObjectivesWe aimed to prospectively investigate the independent and combined relationship between trace elements concentrations [blood (selenium, manganese), serum (copper, zinc), and urine (cobalt, molybdenum, tin, strontium, iodine)] and all-cause mortality.MethodsThis study included 5,412 individuals with demographical, examination, and laboratory data from the National Health and Nutrition Examination Survey. Three statistical models, including Cox proportional hazards models, restricted cubic spline models, and Bayesian kernel machine regression (BKMR) models, were conducted to estimate the longitudinal relationship between trace elements and all-cause mortality.ResultsThere were 356 deaths documented with a median follow-up time of 70 months. In the single-exposure model, the results showed that compared with the lowest quartile, the adjusted hazard ratios (HRs) of mortality for the highest quartile of selenium, manganese, and strontium were 0.47 (95% CI: 0.28–0.79), 1.57 (95% CI: 1.14–2.14), and 0.47 (95% CI: 0.26–0.86), respectively. A nonlinear relationship between zinc, cobalt and mortality was also observed. Furthermore, a significant overall effect of mixtures of trace elements on all-cause mortality was identified, especially when the mixture was at the 60th percentile or lower.ConclusionThe association of multiple trace elements with all-cause mortality was identified in this study. It is recommended that healthcare providers and relevant public health agencies should strengthen the surveillance and management of trace elements. Emphasis should be placed on monitoring the sources of trace elements such as the body, food, and environment. More population studies and animal experiments should be conducted to identify the underlying mechanisms.
Food insecurity in Piura, Peru, in the context of post-earthquake and the COVID-19 pandemic
Authors: Valladares-Garrido Mario J. , Zapata-Castro Luis E. , García-Vicente Abigaíl , León-Figueroa Darwin A. , Huamani-Colquichagua Yanela , Huaman-Garcia Mariana , Calle-Preciado Raul E. , Valladares-Garrido Danai , Díaz-Vélez Cristian , Failoc-Rojas Virgilio E. , Vera-Ponce Víctor J. , Pereira-Victorio César Johan 
Published: July 2023

IntroductionPiura, located in a seismic zone, faces challenges related to food security. The aim of this study was to analyze aspects related to food insecurity in the region following the 6.1-magnitude earthquake that occurred in 2021, within the context of the COVID-19 pandemic.MethodsA secondary analysis was performed in 177 people exposed to the earthquake in Piura. Food insecurity was assessed with the Household Food Insecurity Access Scale. Its association with insomnia, resilience, anxiety/depressive symptoms, and general variables were determined using generalized linear models.ResultsFood insecurity was observed in 31.1% (95% CI: 24.3–38.4) of participants. This prevalence was higher in people with mild (PR: 1.73, 95% CI: 1.12–2.70) and moderate (PR: 1.55, 95% CI: 1.09–2.22) anxiety symptoms, severe depressive symptoms (PR: 2.74, 95% CI: 1.24–6.03), and previous exposure to the El Niño Phenomenon (PR: 1.72; 95% CI: 1.06–2.81). An income higher than 5000 Peruvian soles (approximately 1300 US dollars) was associated with a lower prevalence of food insecurity (PR: 0.22, 95% CI: 0.13–0.40).ConclusionsOverall, three out of 10 individuals experienced food insecurity after the 2021 earthquake in Piura. Food insecurity may be aggravated by mental disorders, previous exposure to the El Niño phenomenon, and the COVID-19 pandemic. Our study contributes to the field by exploring a range of variables related to food insecurity in a unique context: post-earthquake and during the COVID-19 health emergency in Peru. These findings enhance our understanding of food insecurity at the regional level and highlight the need for preventive food security programs in seismic events.
Cross-country analysis of national mental health investment case studies in sub-Saharan Africa and Central, South and South-East Asia
Authors: Chisholm Dan , Lee Yong Yi , Baral Phanindra Prasad , Bhagwat Sadhana , Dombrovskiy Vladislav , Grafton Daniel , Kontsevaya Anna , Huque Rumana , Kalani Okware Kenneth , Kulikov Alexey , Marahatta Kedar , Mavunganidze Patience , Omar Nasri , Prasai Devi , Putoud Nadia , Tsoyi Elena , Vergara Jasmine 
Published: July 2023

IntroductionDespite the increasing interest in and political commitment to mental health service development in many regions of the world, there remains a very low level of financial commitment and corresponding investment. Assessment of the projected costs and benefits of scaling up the delivery of effective mental health interventions can help to promote, inform and guide greater investment in public mental health.MethodsA series of national mental health investment case studies were carried out (in Bangladesh, Kenya, Nepal, Philippines, Uganda, Uzbekistan and Zimbabwe), using standardized guidance developed by WHO and UNDP and implemented by a multi-disciplinary team. Intervention costs and the monetized value of improved health and production were computed in national currency units and, for comparison, US dollars. Benefit-cost ratios were derived.FindingsAcross seven countries, the economic burden of mental health conditions was estimated at between 0.5%–1.0% of Gross Domestic Product. Delivery of an evidence-based package of mental health interventions was estimated to cost US$ 0.40–2.40 per capita per year, depending on the country and its scale-up period. For most conditions and country contexts there was a return of &gt;1 for each dollar or unit of local currency invested (range: 0.0–10.6 to 1) when productivity gains alone are included, and &gt;2 (range: 0.4–30.3 to 1) when the intrinsic economic value of health is also considered. There was considerable variation in benefit-cost ratios between intervention areas, with population-based preventive measures and treatment of common mental, neurological and conditions showing the most attractive returns when all assessed benefits are taken into account.Discussion and ConclusionPerforming a mental health investment case can provide national-level decision makers with new and contextualized information on the outlays and returns that can be expected from renewed local efforts to enhance access to quality mental health services. Economic evidence from seven low- and middle-income countries indicates that the economic burden of mental health conditions is high, the investment costs are low and the potential returns are substantial.
HUBUNGAN IBU HAMIL DENGAN ANEMIA TERHADAP KEJADIAN BERAT BADAN LAHIR RENDAH
Authors: Faradilla Euis Wanti 
Published: July 2023

Anemia disorders that generally occur when pregnant women can cause baby abortion, premature birth and low birth weight (LBW), even stillbirth. The World Health Organization explains that around the world, especially in developing countries, cases of low birth weight births are 96.5% or ± 20 million babies. This study aims to see the correlation of pregnancy with anemia on the incidence of low birth weight at Hospital X, Tangerang distric. This research uses observational method analytics through a retrospective approach, with a case control design. The sampling technique uses a purposive sample, the population is all medical records of newborns at Tangerang distric Hospital X between January 2019 to December 2021. Then the data obtained is analyzed using the Che-Square Test. The results showed that there was a significant correlation between pregnancy with anemia and the incidence of low birth weight at Tangerang distric Hospital x with p 0.002 (p <0.005). with the oods ratio value of 0.503. Where mothers with anemia have a 0.503 times higher risk of low birth weight births compared to pregnant women who are not anemic.
PENGARUH UKURAN PERUSAHAAN, PERTUMBUHAN PERUSAHAAN, DAN PERTUMBUHAN PENJUALAN TERHADAP HARGA SAHAM PERUSAHAAN ENERGY DI BURSA EFEK INDONESIA TAHUN 2020-2021
Authors: Halawa Lestari Putri , Nazmi Hendra , Dewi Sri Puspa , Br Tarigan Rosta Elsabina 
Published: July 2023

Penelitian ini bertujuan untuk mengetahui pengaruh variabel ukuran perusahaan, pertumbuhan perusahaan, dan pertumbuhan penjualan terhadap harga saham pada perusahaan Energy di Bursa Efek Indonesia tahun 2020-2021. Penelitian ini di kelola dengan menggunakan SPSS 25. Perusahaan yang diteliti dalam penelitian ini yaitu perusahaan Energy di Bursa Efek Indonesia dengan populasi terdiri dari 80 perusahaan, dan menggunakan 12 perusahaan sebagai sampel yang memenuhi kriteria dalam penelitian. Berdasarkan hasil uji mengungkapkan bahwa secara parsial variabel Ukuran Perusahaan berpengaruh signifikan terhadap Harga saham pada Perusahaan Energy di Bursa Efek Indonesia tahun 2020 -2021, sedangkan variabel Pertumbuhan perusahaan dan variabel Pertumbuhan Penjualan tidak berpengaruh signifikan terhadap harga saham pada perusahaan Energy di Bursa Efek Indonesia tahun 2020 -2021. Berdasarkan dari hasil pengujian simultan variabel Ukuran perusahaan, Pertumbuhan perusahaan, dan Pertumbuhan Penjualan tidak ada pengaruh terhadap Harga Saham pada Perusahaan Energy di Bursa Efek Indonesia tahun 2020 -2021.
Kata Kunci : Ukuran Perusahaan, Pertumbuhan Perusahaan, Pertumbuhan Penjualan, Harga Saham.
Los veteranos de la milicia y de los cuerpos francos: nacionalización de la memoria de las guerras civiles y coloniales (1839-1910)
Authors: Roca Vernet Jordi 
Published: July 2023

Este artículo analiza las organizaciones de veteranos de la milicia y de las unidades irregulares de voluntarios del ejército, así como su participación en las fiestas y conmemoraciones, con objeto de observar cómo se transformó el relato de la construcción del Estado Liberal. Paulatinamente, con la incorporación de los colectivos de veteranos a la cultura militar, se otorgó agencia política al ejército en la fundamentación del régimen de la Restauración, basándose en las victorias de los militares, y olvidándose de la Revolución Liberal. Durante la década final del siglo XIX y la primera del XX, las organizaciones de veteranos serán utilizadas por distintas prácticas nacionalizadoras en competencia. El caso de los veteranos de la Guerra de África permite demostrar cómo estos pasarán de representar el liberalismo progresista e incluso revolucionario, a encarnar el conservadurismo, católico y anticatalanista.
représentations de l'identité culturelle en classe de fle
Authors: BENABADJI Sarra 
Published: July 2023

Notre réflexion s’inscrit dans un cadre de recherche qui s’intéresse a la représentation de l’identité culturelle, prise en considération dans les textes du manuel scolaire de français de la 3ème année secondaire. L'identité culturelle est un aspect essentiel de l'apprentissage d'une langue étrangère, notamment en classe de français langue étrangère (FLE). Intégrer la dimension culturelle dans l'enseignement du français permet aux apprenants de mieux comprendre et apprécier la langue, ainsi que les contextes sociaux et culturels dans lesquels elle est utilisée. Notre étude s’est penchée sur une analyse descriptive et interprétative des textes qui rend pertinent le rôle de la représentation de l’identité culturelle.
STUDY OF PERSONAL PROFESSIONAL BURNOUT AND MOTIVATION IN THE CONDITIONS OF REMOTE PROFESSIONAL ACTIVITY
Authors: Zurabyan Albert 
Published: July 2023

The years of the COVID-19 pandemic have changed the way we live. In this regard, many companies have switched to the remote format of work, which has put new problems and challenges in front of them. One of those challenges is ensuring professional security in IT usage. Today, the security of the professional person remains a priority for all organizations, and the use of IT, in this context, becomes more important. In the framework of the work, we referred to the psychological aspects of professional security, which have become more significant in terms of the ready implementation of IT under the conditions of the COVID-19 epidemic.
We attempted to study the motives for the deployment of activities of the subjects who were forced to change the classical model of mental activity in the pandemic and post-pandemic conditions of COVID-19, observing its effect on the formation of psychological burnout.
Accordingly, the purpose of the study is to study the influence of motivation in the implementation of professional activities on the formation of psychological burnout among teachers and IT specialists working in an online format:
To achieve the research goal, we have set and solved the following tasks․

identify and justify possible psychological factors affecting the safety of the subject of professional activity
to clarify the impact of the implementation of the IT solution on the security of the subject of professional activity
to clarify the effects of motivations on the formation of psychological burnout of online educators and IT specialists

During the implementation of the research, the method of canceling the syndrome of psychological burnout was applied, developed by A.A. Rukavishnikov and K. Zamfir's "Professional Motivation Study" methodology modified by A. Reana.
The results of the study made it possible to clearly note that teachers and IT specialists, regardless of the nature of the available motives, have high rates of emotional burnout; however, IT specialists with external positive or internal motives have these indicators mildly expressed.
INTERVENSI GIZI DALAM RANGKA PENINGKATAN PENGETAHUAN IBU BALITA TERKAIT STUNTING DI WILAYAH KERJA PUSKESMAS PENGASINAN
Authors: Stefanny Arfenda Laurentine , Noerfitri Noerfitri , Syafidawati Fakhria , Aulia Fitriani Haldin Bizlhi , Rahmawati Dewi , Diahtantri Devina , Fakhirah Hasan Hafizhah , Andini Wening Mahanani Lady 
Published: July 2023

Secara global, ada sebanyak 165 juta anak balita mengalami stunting. Dari angka tersebut sebanyak 90% lebih anak pendek berada di wilayah Afrika dan Asia. Pada tahun 2025 ditargetkan prevalensi stunting turun menjadi 40% secara global. Berdasarkan data SSGBI tahun 2019, prevalensi status gizi balita stunting sebanyak 27,7% dan pada tahun 2021 sebanyak 24,4%. Pemerintah Indonesia menargetkan pada tahun 2024 prevalensi stunting di Indonesia menjadi 14%. Prevalensi stunting di Puskesmas Pengasinan masih sangat tinggi. Ada sebanyak 17,1% balita dalam kondisi pendek dan 31,4% balita dalam kondisi sangat pendek. Dalam rangka menurunkan angka stunting, dilakukan pemberian edukasi gizi tentang stunting pada ibu balita. Kegiatan pengabdian kepada masyarakat ini dilaksanakan pada tanggal 26 Desember 2022 – 20 Januari 2023. Evaluasi kegiatan melalui pengukuran pengetahuang ibu balita terkait stunting pada sebelum dan sesudah mengikuti penyuluhan. Uji statistik yang digunakan adalah uji Wilcoxon-sign rank test. Hasil uji stattistik mendapatkan nilai median skor pengetahuan ibu sebelum penyuluhan sebesar 60,0 dan sesudah penyuluhan sebesar 73,3 dengan p-value sebesar 0,00005. Dapat disimpulkan bahwa terjadi peningkatan pengetahuan ibu balita mengenai stunting.
Investing in Social Capital
Authors: Pumihic Moraya Caclini 
Published: July 2023

Social capital is akin to actual capital in that people with more money are typically better off and have easier access to investment opportunities. The purpose of the study is to determine how and why communities in Ifugao continue to invest in social capital in their cultural practices. Ethnography as a qualitative design, is the inquiry used in this study. Participant’s observation, along with interviews and coupled with focus group discussion are the tools used in collecting data. The data gathered were analyzed using thematic analysis. Findings revealed that majority of the performers and participants are above 55 years old, male, married, college graduates, government employees, and have a monthly salary of over 40,000 Php. Most of the attendees to Ifugao birthdays, engagements, weddings, and death wakes perceived that non-monetary benefits were achieved such as strengthening bonds between families and close friends, bridging links with faraway friends, and connecting relationships with other participants. In terms of investment, the wedding has a high cost, high return, and high return monetary value, while death has a low cost and high return monetary value. Ifugao (Tuwali) cultural community invest in social capital strengthen their families, friends, and communities’ bonds, connections, trust, and reciprocity.
ANALISIS ASPEK EKONOMI LAHAN PEKARANGAN (Studi Kasus di Desa Pandanwangi Kecamatan Diwek Kabupaten Jombang)
Authors: Hamidah Emmy 
Published: July 2023

Paddy fields in urban areas are gradually being used as settlements so that paddy fields are becoming increasingly narrow, as well as dry land. The only hope left for the farm was the homestead. Referring to this problem, it is necessary to examine the Analysis of Economic Aspects of Yard Land. Yard land is the land around the residence where various types of plants are planted, livestock cultivated in the yard needs to be identified and when viewed from an additional income it is necessary to use financial analysis. The aim of the research is to find out what farming is cultivated in the yard of Pandanwangi Village, Diwek District, Jombang Regency, besides that it is also to find out to what extent the yard can increase their income.
The hypothesis in this study is that the yard in Pandanwangi Village, Diwek District, Jombang Regency does not have much influence on increasing the amount of income. The research method uses a descriptive method using a survey. The determination of the area was determined deliberately in Pandanwangi Village, Diwek District, Jombang Regency. How to collect primary and secondary data by using a prepared questionnaire. Determination of respondents using a simple random way as many as 20 respondents. Data analysis used tabulation, income, R/C ratio, BC ratio and t test.
The results showed that the average age of the respondents was 54 years old, including those with a lot of experience and education level, most of them graduated from high school. Yard land ownership 0.123 Ha Yard land in Pandanwangi Village is widely planted with mangoes, bananas, oranges, guava and cassava. The type of fish kept in the yard in Pandanwangi Village is catfish. Most of the livestock kept are poultry, goats and buffaloes. The income received by respondents is quite large, namely IDR 1,688,690 per respondent. The largest income is obtained from crops, livestock and fisheries. The value of the R/C ratio of yard farming in Pandanwangi Village, Diwek District, Jombang Regency = 1.92, statistically the R/C ratio > 1 or yard farming in Pandanwangi Village is very profitable.
МОДЕЛИРОВАНИЕ РАБОТЫ ТРАНСПОРТНО-ЛОГИТИЧЕСКИХ КОМПАНИЙ В КАЗАХСТАНЕ
Authors: Кегенбеков Жандос , Жұманов Азат , Алипова Алима , Есжанова Гульчат 
Published: July 2023

Логистика в Казахстане появилась относительно недавно, но, несмотря на это, развивается огромными темпами. Клиенты требуют все большего и большего от логистов и предоставляемых им продуктов. Логистический подход к объекту управления, инструменты и методы логистики применяются в самых различных областях менеджмента. Изучаются общие вопросы транспортно-экспедиционного обслуживания, классификации транспортно-экспедиционных услуг и основных направлений ее развития, контрактных и договорных отношений между транспортно-экспедиционной компанией и ее клиентурой, принципов транспортно-экспедиторской деятельности на различных видах транспорта, основных положений таможенного обслуживания внешнеэкономической деятельности. В статье рассматриваются технологический процесс оказания услуги транспортно-логистическими компаниями и предложен модель их работы. Описание модели работы логистических компаний достаточно важный процесс для рынка транспортных услуг Казахстана, как для начинающих, так и для практикующих специалистов, которые, смогут подробно ознакомиться с деятельностью экспедитора, основываясь на модели работы логистических компаний.
МАШИНИСТСЫЗ ПОЙЫЗДАРМЕН АВТОМАТТАНДЫРЫЛҒАН МЕТРО ЖЕЛІСІН ЕНГІЗУ МӘСЕЛЕСІНЕ
Authors: Мусаев Жанат , Туркебаев Мукангали , Утепова Акерке , Касымова Акмаржан , Курмашев Бауржан 
Published: July 2023

Теміржолдағы пилотсыз технологиялардың дамуы ұзақ уақыт бойы, 1957 жылы қала маңындағы пойыздарға арналған алғашқы эксперименттік автотану кешені құрылған кезде басталды. Технологиялық дамыған елдерде пойыздарды пилотсыз режимде басқаруға мүмкіндік беретін зияткерлік жүйелермен және техникалық көру жүйелерімен жабдықтау бойынша белсенді жұмыс жүргізілуде. Құзыретті мамандардың пікірінше, болашақта техникалық көру жүйелері кедергілерді анықтаған кезде адамның көру қабілетіне қарағанда жақсы жұмыс істейді, демек, жаяу жүргіншілер мен жолаушылардың қауіпсіздігі жақсарады. Мақалада Қазақстанда автоматтандырылған метро жүйелерін дамыту және енгізу перспективалары қарастырылған. Пилотсыз МЕТРО пойыз жүйелерін пайдаланудың артықшылықтары көрсетілген. Пилотсыз технологиялар негізінде автоматтандырылған метро желісін енгізу жобасы ұсынылды.