bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semantic guidance network for video captioning
Authors: Guo Lan , Zhao Hong , Chen ZhiWen , Han ZeYu 
Published: September 2023

Abstractvideo captioning is a more challenging task that aims to generate abundant natural language descriptions, and it has become a promising direction for artificial intelligence. However, most existing methods are prone to ignore the problems of visual information redundancy and scene information omission due to the limitation of the sampling strategies. To address this problem, a semantic guidance network for video captioning is proposed. More specifically, a novel scene frame sampling strategy is first proposed to select key scene frames. Then, the vision transformer encoder is applied to learn visual and semantic information with a global view, alleviating information loss of modeling long-range dependencies caused in the encoder’s hidden layer. Finally, a non-parametric metric learning module is introduced to calculate the similarity value between the ground truth and the prediction result, and the model is optimized in an end-to-end manner. Experiments on the benchmark MSR-VTT and MSVD datasets show that the proposed method can effectively improve the description accuracy and generalization ability.
First report of Neoscytalidium dimidiatum as the causal agent of leaf blight on Clivia miniata
Authors: Zaeimian Zahra , Fotouhifar Khalil-Berdi 
Published: September 2023

AbstractIn this survey, the symptomatic leaves of Clivia miniata were collected from a greenhouse in Karaj city of Iran. The isolation and morphological investigation showed Scytalidium-like fungus associated with leaf blight symptom. The phylogenetic analysis of the internal transcribed spacer along with partial sequences of rDNA large subunit and translation elongation factor 1-α (tef-1α) genomic regions confirmed the identification of the recovered isolate as Neoscytalidium dimidiatum. The pycnidial morph of the fungus didn’t observe both in vitro and in vivo. The pathogenicity test on C. miniata and C. nobilis was also conducted to fulfill the Koch’s postulates. To our Knowledges, this is the first report of N. dimidiatum causing leaf blight disease on C. miniata and C. nobilis worldwide, as well as these host plants are new for N. dimidiatum in the world.
Pressure overload-induced systolic heart failure is associated with characteristic myocardial microRNA expression signature and post-transcriptional gene regulation in male rats
Authors: Ruppert Mihály , Korkmaz-Icöz Sevil , Benczik Bettina , Ágg Bence , Nagy Dávid , Bálint Tímea , Sayour Alex Ali , Oláh Attila , Barta Bálint András , Benke Kálmán , Ferdinandy Péter , Karck Matthias , Merkely Béla , Radovits Tamás , Szabó Gábor 
Published: September 2023

AbstractAlthough systolic function characteristically shows gradual impairment in pressure overload (PO)-evoked left ventricular (LV) hypertrophy (LVH), rapid progression to congestive heart failure (HF) occurs in distinct cases. The molecular mechanisms for the differences in maladaptation are unknown. Here, we examined microRNA (miRNA) expression and miRNA-driven posttranscriptional gene regulation in the two forms of PO-induced LVH (with/without systolic HF). PO was induced by aortic banding (AB) in male Sprague–Dawley rats. Sham-operated animals were controls. The majority of AB animals demonstrated concentric LVH and slightly decreased systolic function (termed as ABLVH). In contrast, in some AB rats severely reduced ejection fraction, LV dilatation and increased lung weight-to-tibial length ratio was noted (referred to as ABHF). Global LV miRNA sequencing revealed fifty differentially regulated miRNAs in ABHF compared to ABLVH. Network theoretical miRNA-target analysis predicted more than three thousand genes with miRNA-driven dysregulation between the two groups. Seventeen genes with high node strength value were selected for target validation, of which five (Fmr1, Zfpm2, Wasl, Ets1, Atg16l1) showed decreased mRNA expression in ABHF by PCR. PO-evoked systolic HF is associated with unique miRNA alterations, which negatively regulate the mRNA expression of Fmr1, Zfmp2, Wasl, Ets1 and Atg16l1.
The C-terminal transactivation domain of MITF interacts promiscuously with co-activator CBP/p300
Authors: Brown Alexandra D. , Lynch Kyle , Langelaan David N. 
Published: September 2023

AbstractThe microphthalmia-associated transcription factor (MITF) is one of four closely related members of the MiT/TFE family (TFEB, TFE3, TFEC) that regulate a wide range of cellular processes. MITF is a key regulator of melanocyte-associated genes, and essential to proper development of the melanocyte cell lineage. Abnormal MITF activity can contribute to the onset of several diseases including melanoma, where MITF is an amplified oncogene. To enhance transcription, MITF recruits the co-activator CREB-binding protein (CBP) and its homolog p300 to gene promoters, however the molecular determinants of their interaction are not yet fully understood. Here, we characterize the interactions between the C-terminal MITF transactivation domain and CBP/p300. Using NMR spectroscopy, protein pulldown assays, and isothermal titration calorimetry we determine the C-terminal region of MITF is intrinsically disordered and binds with high-affinity to both TAZ1 and TAZ2 of CBP/p300. Mutagenesis studies revealed two conserved motifs within MITF that are necessary for TAZ2 binding and critical for MITF-dependent transcription of a reporter gene. Finally, we observe the transactivation potential of the MITF C-terminal region is reliant on the N-terminal transactivation domain for function. Taken together, our study helps elucidate the molecular details of how MITF interacts with CBP/p300 through multiple redundant interactions that lend insight into MITF function in melanocytes and melanoma.
The direction of effects between parenting and adolescent affective well-being in everyday life is family specific
Authors: Boele Savannah , Bülow Anne , Beltz Adriene M. , de Haan Amaranta , Denissen Jaap. J. A. , Keijsers Loes 
Published: September 2023

AbstractNumerous theories and empirical studies have suggested that parents and their adolescent children reciprocally influence each other. As most studies have focused on group-level patterns, however, it remained unclear whether this was true for every family. To investigate potential heterogeneity in directionality, we applied a novel idiographic approach to examine the effects between parenting and adolescent well-being in each family separately. For 100 days, 159 Dutch adolescents (Mage = 13.31, 62% female) reported on affective well-being and four parenting dimensions. The family-specific effects of pre-registered (https://osf.io/7n2jx/) dynamic structural equation models indeed revealed that a reciprocal day-to-day association between parenting and adolescent affective well-being was present only in some families, with the proportion of families displaying a reciprocal association varying across the four parenting dimensions (11–55%). In other families, either parenting predicted the adolescent’s affective well-being (8–43%) or vice versa (10–27%), or no day-to-day associations were found (16–60%). Adolescents with higher trait levels of environmental sensitivity and neuroticism were more strongly affected by parenting. Thus, findings suggest that the ways in which parents and adolescents influence each other in everyday life are unique, stressing the need to move towards an idiographic parenting science.
Polydimethylsiloxane as a more biocompatible alternative to glass in optogenetics
Authors: Andersen Michael Aagaard , Schouenborg Jens 
Published: September 2023

AbstractOptogenetics is highly useful to stimulate or inhibit defined neuronal populations and is often used together with electrophysiological recordings. Due to poor penetration of light in tissue, there is a need for biocompatible wave guides. Glass wave guides are relatively stiff and known to cause glia reaction that likely influence the activity in the remaining neurons. We developed highly flexible micro wave guides for optogenetics that can be used in combination with long-lasting electrophysiological recordings. We designed and evaluated polydimethylsiloxane (PDMS) mono-fibers, which use the tissue as cladding, with a diameter of 71 ± 10 µm and 126 ± 5 µm. We showed that micro PDMS fibers transmitted 9–33 mW/mm2 light energy enough to activate channelrhodopsin. This was confirmed in acute extracellular recordings in vivo in which optogenetic stimulation through the PDMS fibers generated action potentials in rat hippocampus with a short onset latency. PDMS fibers had significantly less microglia and astrocytic activation in the zone nearest to the implant as compared to glass. There was no obvious difference in number of adjacent neurons between size matched wave guides. Micro PDMS wave guide demonstrates in vivo functionality and improved biocompatibility as compared to glass. This enables the delivery of light with less tissue damage.
Deterministic field-free voltage-induced magnetization switching with self-regulated precession for low-power memory
Authors: Sin Stanislav , Oh Saeroonter 
Published: September 2023

AbstractSpintronic devices are regarded as a promising solution for future computing and memory technologies. They are non-volatile, resilient to radiation, and compatible with the CMOS back-end process. However, the major drawbacks of modern current-driven spintronic devices are the long switching delay and relatively high power consumption. Recent progress in magnetoelectronics, particularly in voltage-controlled magnetism reveals a possible solution. Voltage-controlled magnetic anisotropy (VCMA) allows the manipulation of interface-mediated perpendicular anisotropy energy. However, most VCMA-based switching methods require pre-read operation, precise pulse-width control and have high write error rate. This study proposes a novel deterministic self-regulated precessional ferromagnet switching method, which overcomes these issues. In the discussed method, energy symmetry is broken by a dependence of MTJ resistance on the angle between magnetization vectors of free and pinned layers. Hence, the method does not require an external magnetic field and large electric current. The proposed method is verified through micromagnetic simulations and benchmarked with other methods typically reported in the literature. We report the write error rate is significantly improved compared to other VCMA switching methods. Moreover, the mean energy consumption is as low as 38.22 fJ and the mean switching delay is 3.77 ns.
The ratio of mesoscale convective system precipitation to total precipitation increases in future climate change scenarios
Authors: Haberlie Alex M. , Ashley Walker S. , Gensini Victor A. , Michaelis Allison C. 
Published: September 2023

AbstractMesoscale convective systems (MCSs) are a substantial source of precipitation in the eastern U.S. and may be sensitive to regional climatic change. We use a suite of convection-permitting climate simulations to examine possible changes in MCS precipitation. Specifically, annual and regional totals of MCS and non-MCS precipitation generated during a retrospective simulation are compared to end-of-21st-century simulations based on intermediate and extreme climate change scenarios. Both scenarios produce more MCS precipitation and less non-MCS precipitation, thus significantly increasing the proportion of precipitation associated with MCSs across the U.S.
Schistosoma mansoni excretory-secretory products induce protein kinase signalling, hyperkinesia, and stem cell proliferation in the opposite sex
Authors: Shakir Eman M. N. , Rinaldi Gabriel , Kirk Ruth S. , Walker Anthony J. 
Published: September 2023

AbstractAdult male and female schistosomes in copula dwell within human blood vessels and lay eggs that cause the major Neglected Tropical Disease human schistosomiasis. How males and females communicate to each other is poorly understood; however, male-female physical interaction is known to be important. Here, we investigate whether excretory-secretory products (ESPs), released into the external milieu by mature Schistosoma mansoni, might induce responses in the opposite sex. We demonstrate that ESPs adhere to the surface of opposite sex worms inducing the activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38 MAPK) pathways, particularly in the parasite tegument. Furthermore, we show that mature worms stimulated signalling in juvenile worms. Strikingly, we demonstrate that ESPs from the opposite sex promote stem cell proliferation, in an ERK- and p38 MAPK-dependent manner, in the tegument and within the testes of males, and the ovaries and vitellaria of females. Hyperkinesia also occurs following opposite sex ESP exposure. Our findings support the hypothesis that male and female schistosomes may communicate over distance to modulate key processes underlying worm development and disease progression, opening unique avenues for schistosomiasis control.
Single-polyp metabolomics reveals biochemical structuring of the coral holobiont at multiple scales
Authors: Roach Ty N. F. , Matsuda Shayle B. , Martin Christian , Huckeba Gintare , Huckeba Joel , Kahkejian Valerie , Santoro Erika P. , van der Geer Anneke , Drury Crawford , Quinn Robert A. 
Published: September 2023

AbstractAll biology happens in space, and spatial structuring plays an important role in mediating biological processes at all scales from cells to ecosystems. However, the metabolomic structuring of the coral holobiont has yet to be fully explored. Here, we present a method to detect high-quality metabolomic data from individual coral polyps and apply this method to study the patterning of biochemicals across multiple spatial (~1 mm - ~100 m) and organizational scales (polyp to population). The data show a strong signature for individual coral colonies, a weaker signature of branches within colonies, and variation at the polyp level related to the polyps’ location along a branch. Mapping metabolites to either the coral or algal components of the holobiont reveals that polyp-level variation along the length of a branch was largely driven by molecules associated with the cnidarian host as opposed to the algal symbiont, predominantly putative sulfur-containing metabolites. This work yields insights on the spatial structuring of biochemicals in the coral holobiont, which is critical for design, analysis, and interpretation of studies on coral reef biochemistry.
Algorithm for fast evaluation of in-plane fiber orientation in reinforced plastics using light microscopy images
Authors: Wiegel Klara , Schlink André , Eckel Elisabeth , Ayeb Mohamed , Brabetz Ludwig , Hartung Michael , Heim Hans-Peter 
Published: September 2023

AbstractMethods for evaluating the orientation of carbon fibers in reinforced plastics vary in complexity and are application specific. Here, we report an algorithm that quickly evaluates in-plane fiber orientation based on determining the correlation coefficient of adjacent regions in microscopy images. The result is not the fiber orientation of individual fibers, but the principal fiber orientation of small image areas. This method is applicable to large areas due to its low computation time and captures varying fiber orientations, making it suitable for the study of injection molded samples with complex geometries. A great advantage is that no information about the fibers or the matrix, or their combination, is needed prior to the analysis. This approach is also suitable for samples with surface defects. Demonstrations of this technique are given for Polyamide 6 and Polypropylene with 30 weight % carbon fibers of different fiber lengths.
Association between cumulative exposure periods of flupentixol or any antipsychotics and risk of lung cancer
Authors: Chai Yi , Chu Rachel Yui Ki , Hu Yuqi , Lam Ivan Chun Hang , Cheng Franco Wing Tak , Luo Hao , Wong Martin Chi Sang , Chan Sandra Sau Man , Chan Esther Wai Yin , Wong Ian Chi Kei , Lai Francisco Tsz Tsun 
Published: September 2023

Abstract
Background
Preclinical evidence suggests that certain antipsychotic medications may inhibit the development of lung cancer. This study aims to investigate the association between incident lung cancer and different cumulative exposure periods of flupentixol or any antipsychotics.

Methods
Using electronic health records from the Hospital Authority in Hong Kong, this nested case-control study included case participants aged 18 years or older with newly diagnosed lung cancer after initiating antipsychotics between January 1, 2003, and August 31, 2022. Each case was matched to up to ten controls of the same sex and age, who were also antipsychotic users. Multivariable conditional logistic regression models were conducted to quantify the association between lung cancer and different cumulative exposure times of flupentixol (0–365 days [ref]; 366–1825 days; 1826+ days) and any antipsychotics (1–365 days [ref]; 366–1825 days; 1826+ days), separately.

Results
Here we show that among 6435 cases and 64,348 matched controls, 64.06% are males, and 52.98% are aged 65–84 years. Compared to patients with less than 365 days of exposure, those with 366–1825 days of exposure to flupentixol (OR = 0.65 [95% CI, 0.47–0.91]) and any antipsychotics (0.42 [0.38–0.45]) have a lower risk of lung cancer. A decreased risk is observed in patients who have 1826+ days of cumulative use of any antipsychotics (0.54 [0.47–0.60]).

Conclusions
A reduced risk of lung cancer is observed in patients with more than one year of exposure to flupentixol or any antipsychotics. Further research on the association between lung cancer and other antipsychotic agents is warranted.
A wideband and high‐gain switched‐beam antenna system using active frequency selective surface
Authors: Chen Zhenzhen , Qiao Huimin , Chen Qiang , Chen Xing 
Published: September 2023

AbstractAntennas using the active frequency selective surface (AFSS) can achieve fast beam‐scanning ability at a low cost. In this study, a switched beam antenna with a high gain and 360° coverage in the horizontal plane is proposed. Twelve columns of AFSS form a cylindrical cavity and are transmissive or reflective to the incident electromagnetic waves under the control of PIN diodes. Benefiting from a coaxial continuous transverse stub array placed at the cavity centre and using 4 units to generate a high gain omnidirectional radiation, the proposed antenna can realise a highly directive switched beam. An antenna prototype is designed, fabricated and measured. Results show that it achieves a |S11| < −10 dB bandwidth of 12.9% and is able to sweep its beam around the azimuth plane with a high gain up to 13.6 dBi at 5.8 GHz working frequency.
Besonderheiten in der Therapie des TTF-1-negativen Adenokarzinoms der Lunge
Authors: Frost Nikolaj , Reck Martin 
Published: September 2023

ZusammenfassungDie Identifikation Biomarker-stratifizierter Behandlungen hat das Überleben eines relevanten Anteils an Patient*innen mit metastasiertem Lungenkrebs in den letzten Jahren teils erheblich verbessert. Hierzu zählen Treibermutationen und bei Treiber-negativen Tumoren die Expression des „programmed death ligand 1“ (PD-L1) hinsichtlich des Ansprechens auf eine Therapie mit Checkpoint-Inhibitoren. Aufgrund der beim Lungenkarzinom bestehenden Korrelation zwischen PD-L1-Expression und Behandlungseffektivität kommt insbesondere bei geringer oder fehlender Expression der zusätzlich applizierten Chemotherapie eine wichtige Rolle zu. Derzeitig erhalten Patient*innen im Stadium IV mit einer PD-L1-Expression <50% auf den Tumorzellen eine Chemoimmuntherapie zur Erstlinienbehandlung. Hierzu stehen Pemetrexed- und Taxan-basierte Regime zur Auswahl. In retrospektiven Analysen zeigte sich bei für den thyroidalen Transkriptionsfaktor 1 (TTF-1)-negativen Patient*in ein im Vergleich zu Pemetrexed-basierter Therapie verbessertes Überleben bei Verwendung Taxan-haltiger Regime. Diese Beobachtung wird aktuell prospektiv randomisiert untersucht.
Endoscopic Submucosal Dissection of a Giant Rectal Adenoma Manifesting as McKittrick-Wheelock Syndrome
Authors: Kouladouros Konstantinos , Schneider Klaus , Kubicka Stefan , Hoerner Christian , Hirth Michael 
Published: September 2023

AbstractMcKittrick–Wheelock syndrome (MKWS) is an uncommon clinical manifestation of large, villous, epithelial lesions of the distal colon and rectum. Excessive secretion of electrolyte-rich mucus from these lesions leads to secretory diarrhea, electrolyte disorders and acute renal failure. Several cases of MKWS have been reported since its initial description in 1954. The definitive treatment for the great majority of MKWS cases has consisted of surgical resection of the affected part of the colorectum, usually in the form of a low anterior resection or an abdominoperineal resection with the formation of an ostomy. Recent developments in endoscopic resection techniques now offer new, minimally invasive treatment alternatives for MKWS patients. We present the first reported case in the Western world of MKWS caused by a rectal adenoma with a size of 19 × 10 cm, treated through endoscopic submucosal dissection. Through the lessons learned by this case, as well as by a thorough review of the literature, we discuss this uncommon syndrome, focusing on treatment alternatives.
Lipedema associated with Skin Hypoperfusion and Ulceration: Soft Tissue Debulking Improving Skin Perfusion
Authors: Alshomer Feras , Lee Seok Joon , Kim Yeongsong , Hong Dae Won , Pak Changsik John , Suh Hyunsuk Peter , Hong Joon Pio 
Published: September 2023

AbstractLipedema is a progressive connective tissue disease with enlargement of adipose tissue, fibrosis, fluid collection, and dermal thickening. Herein, we present a case of lipedema associated with skin hypoperfusion and ulceration in which soft tissue debulking with liposuction improved patients' symptoms. A 39-year-old female presented with asymmetric progressive initially unilateral lower limb swelling with severe pain with subsequent skin ulceration. Conservative management failed to improve her condition. After excluding other causes and detailed radiologic investigation, lipedema was diagnosed with an associated impaired skin perfusion. Trial of local wound care and compression therapy failed to improve the condition. Subsequent soft tissue debulking with circumferential liposuction and ulcer debridement and immediate compression showed dramatic improvement of the symptoms and skin perfusion. The unique nature of this case sheds light on lipedema as a loose connective tissue disease. Inflammation and microangiopathies explain the associated pain with hypoperfusion and ulceration being quite atypical and in part might be related to the large buildups of matrix proteins and sodium contents leading to fragility in microvessels with frequent petechiae and hematoma and subsequent tissue ischemia. Conservative measures like compression therapy plays a significant role in disease course. Surgical debulking with liposuction was shown to be efficacious in reducing the soft tissue load with improvement in limb pain, edema, circumference, and skin perfusion that was seen in our patient. Lipedema is a frequently misdiagnosed condition with disabling features. Skin involvement in lipedema with potential hypoperfusion was shown and it requires further investigation.