bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstruction of Solid Electrolyte Interphase with SrI2 Reactivates Dead Li for Durable Anode‐Free Li‐Metal Batteries
Authors: Dong Liwei , Zhong Shijie , Yuan Botao , Li Yaqiang , Liu Jipeng , Ji Yuanpeng , Chen Dongjiang , Liu Yuanpeng , Yang Chunhui , Han Jiecai , He Weidong 
Published: April 2023

AbstractWithout excess Li, anode‐free Li‐metal batteries (AFLMBs) have been proposed as the most likely solution to realizing highly‐safe and cost‐effective Li‐metal batteries. Nevertheless, short cyclic life puzzles conventional AFLMBs due to anodic dead Li accumulation with a local current concentration induced by irreversible electrolyte depletion, insufficient active Li reservoir and slow Li+ transfer at the solid electrolyte interphase (SEI). Herein, SrI2 is introduced into carbon paper (CP) current collector to effectively suppress dead Li through synergistic mechanisms including reversible I−/I3− redox reaction to reactivate dead Li, dielectric SEI surface with SrF2 and LiF to prevent electrolyte decomposition and highly ionic conductive (3.488 mS cm−1) inner layer of SEI with abundant LiI to enable efficient Li+ transfer inside. With the SrI2‐modified current collector, the NCM532/CP cell delivers unprecedented cyclic performances with a capacity of 129.2 mAh g−1 after 200 cycles.
Palladium‐Catalyzed Inverse and Normal Dehydrogenative Aza‐Morita–Baylis–Hillman Reactions with γ,δ‐Unsaturated Compounds
Authors: Chen Peng , Tan Shun‐Zhong , Zhu Lei , Ouyang Qin , Jia Zhi‐Jun , Du Wei , Chen Ying‐Chun 
Published: April 2023

Abstractσ‐Lewis base‐catalyzed regio‐ and enantioselective aza‐Morita–Baylis–Hillman (MBH) reaction of α,β,γ,δ‐unsaturated systems remains a challenge due to the intrinsic covalent activation mode. Here we demonstrate that a Pd0 complex can mediate the dehydrogenative reaction of γ,δ‐unsaturated compounds to give corresponding electron‐poor dienes, which further undergo δ‐regioselective umpolung Friedel–Crafts‐type addition to imines via auto‐tandem Pd0‐π‐Lewis base catalysis. After β‐H elimination of in situ formed PdII‐complexes, unprecedented and chemically inverse aza‐MBH‐type adducts are finally furnished with fair to outstanding enantioselectivity, and a diversity of functional groups and both ketimine and aldimine acceptors can be well tolerated. Moreover, switchable α‐regioselective normal aza‐MBH‐type reaction also can be realized by tuning catalytic conditions, whereas moderate to good enantioselectivity with low to excellent Z/E‐selectivity is attained.
A Fused [5]Helicene Dimer with a Figure‐Eight Topology: Synthesis, Chiral Resolution, and Electronic Properties
Authors: Zhou Qifeng , Hou Xudong , Wang Jinyi , Ni Yong , Fan Wei , Li Zhengtao , Wei Xiao , Li Ke , Yuan Wei , Xu Zhuofan , Zhu Manzhou , Zhao Yanli , Sun Zhe , Wu Jishan 
Published: April 2023

AbstractChiral shape‐persistent molecular nanocarbons are promising chiroptical materials; their synthesis, however, remains a big challenge. Herein, we report the facile synthesis and chiral resolution of a double‐stranded figure‐eight carbon nanobelt 1 in which two [5]helicene units are fused together. Two synthetic routes were developed, and, in particular, a strategy involving Suzuki coupling‐mediated macrocyclization followed by Bi(OTf)3‐catalyzed cyclization of vinyl ether turned out to be the most efficient. The structure of 1 was confirmed by X‐ray crystallographic analysis. The isolated (P,P)‐ and (M,M)‐ enantiomers show persistent chiroptical properties with relatively large dissymmetric factors (|gabs|=5.4×10−3 and |glum|=1.0×10−2), which can be explained by the effective electron delocalization along the fully conjugated belt and the unique D2 symmetry. 1 exhibits local aromatic character with a dominant structure containing eight Clar's aromatic sextet rings.
Development of thermoplastic polyether ester elastomer microcellular foam with high resilience: Effect of chain extension on foaming behavior and mechanical properties
Authors: Yu Leilei , Yu Zhen , Yang Lijuan , Wen Shibao , Zhang Zhen Xiu 
Published: April 2023

AbstractThe lightweight development of thermoplastic polyether ester elastomer (TPEE) has been limited by its low‐melt strength. In this work, the epoxy chain extender ADR was employed to improve TPEE's melt strength in order to enhance its foamability by supercritical N2 (sc‐N2). The results showed that the melt strength of TPEE increased gradually with the increase of ADR content, which led to the uniformity of the foam cell structure and the improvement of its mechanical properties, that is, a high resilience of 82%. However, when ADR content exceeded 1.6 phr, the viscosity was too high to induce foaming. Remarkably, the maximum stress retention of TPEE foam with 1.6 phr ADR remained at 90% after 50 cycles of compression, while the strain recovery rate was higher than 85%. The prepared TPEE foam has excellent resilience and dynamic mechanical properties, which broadens its application in fields of midsole, sports equipment and transportation.
Some psychoanalytic reflections on the Irish real estate bubble
Authors: Ryan Paul , Taffler Richard J. , Branigan Clare 
Published: April 2023

AbstractWe use the recent destructive Irish residential real estate bubble and its parlous economic and social consequences to explore the role of repressed ancestral suffering in driving institutional and broader societal responses to contemporary events. We demonstrate how a traumatic past can become interwoven in the fabric of the social order, rendering state and parastatal organizations and their leaders powerless. The concept of intergenerational transmission of trauma is key to our analysis. We show how the Irish obsession with owning property and land is a psychic attempt to transcend the traumatic past to “inhabit” an idealized pre‐colonial land leading to emergent feelings of empowerment, euphoria and omnipotence. We also explain why the Irish real estate bubble is being re‐enacted so soon. The potential to enhance interpretation through insights from literature, drama, and poetry is illustrated.
Use of ultrasound in gradient elution of Polycyclic Aromatic Hydrocarbon mixtures by HPLC
Authors: Jeong Young Han , Eun Danbi , Van Kien Nguyen , Seog David Jin Han , Ryoo Jae Jeong 
Published: April 2023

AbstractStainless steel (SS) and polyether ether ketone (PEEK) C18 columns were submerged in an ultrasonic bath operating at a frequency of 36 kHz to separate a mixture of polycyclic aromatic hydrocarbons (PAHs), including naphthalene, anthracene, and pyrene, using high‐performance liquid chromatography (HPLC) with ultrasound radiation applied at intensities ranging from 0% to 100% of the 900 W output power. Sono‐gradient elution was used to ultrasonically irradiate the mixture at specific points during the elution to improve the separation factor by increasing the interval between the target peaks and shorten the analysis time by reducing the retention time of the desired PAH peak.
PROTOCOL: Participation in organised sport to improve and prevent adverse developmental trajectories of at‐risk youth: A systematic review
Authors: Filges Trine , Verner Mette , Ladekjær Else , Bengtsen Elizabeth 
Published: April 2023

AbstractThis is the protocol for a Campbell systematic review. The main objective of this review is to answer the research question: What are the effects of organised sport on risk behaviour, personal, emotional and social skills of young people, who either have experienced or is at‐risk of experiencing an adverse outcome? Further, the review will attempt to answer if the effects differ between participants characteristics such as gender, age and risk indicator or between types of sport (e.g., team/individual, contact/non‐contact, intensity and duration).
Targeting alarmin release reverses Sjogren's syndrome phenotype by revitalizing Ca2+ signalling
Authors: Sun Yuyang , Nascimento Da Conceicao Viviane , Chauhan Arun , Sukumaran Pramod , Chauhan Pooja , Ambrus Julian L. , Vissink Arjan , Kroese Frans G. M. , Muniswamy Madesh , Mishra Bibhuti B. , Singh Brij B. 
Published: April 2023

AbstractBackgroundPrimary Sjogren's syndrome (pSS) is a systemic autoimmune disease that is embodied by the loss of salivary gland function and immune cell infiltration, but the mechanism(s) are still unknown. The aim of this study was to understand the mechanisms and identify key factors that leads to the development and progression of pSS.MethodsImmunohistochemistry staining, FACS analysis and cytokine levels were used to detect immune cells infiltration and activation in salivary glands. RNA sequencing was performed to identify the molecular mechanisms involved in the development of pSS. The function assays include in vivo saliva collection along with calcium imaging and electrophysiology on isolated salivary gland cells in mice models of pSS. Western blotting, real‐time PCR, alarmin release, and immunohistochemistry was performed to identify the channels involved in salivary function in pSS.ResultsWe provide evidence that loss of Ca2+ signaling precedes a decrease in saliva secretion and/or immune cell infiltration in IL14α, a mouse model for pSS. We also showed that Ca2+ homeostasis was mediated by transient receptor potential canonical‐1 (TRPC1) channels and inhibition of TRPC1, resulting in the loss of salivary acinar cells, which promoted alarmin release essential for immune cell infiltration/release of pro‐inflammatory cytokines. In addition, both IL14α and samples from human pSS patients showed a decrease in TRPC1 expression and increased acinar cell death. Finally, paquinimod treatment in IL14α restored Ca2+ homeostasis that inhibited alarmin release thereby reverting the pSS phenotype.ConclusionsThese results indicate that loss of Ca2+ signaling is one of the initial factors, which induces loss of salivary gland function along with immune infiltration that exaggerates pSS. Importantly, restoration of Ca2+ signaling upon paquinimod treatment reversed the pSS phenotype thereby inhibiting the progressive development of pSS.
Transcriptional programing of T cell metabolism by STAT family transcription factors
Authors: Villarino Alejandro V. 
Published: April 2023

AbstractT cells adapt their metabolism to meet the energetic and biosynthetic demands imposed by changes in location, behavior, and/or differentiation state. Many of these adaptations are controlled by cytokines. Traditionally, research on the metabolic properties of cytokines has focused on downstream signaling via the PI3K‐AKT, mTOR, or ERK‐MAPK pathways but recent studies indicate that JAK‐STAT is also crucial. This review synthesizes current thinking on how JAK‐STAT signaling influences T cell metabolism, focusing on adaptations necessary for the naïve, effector, regulatory, memory, and resident‐memory states. The overarching theme is that JAK‐STAT has both direct and indirect effects. Direct regulation involves STATs localizing to and instructing expression of metabolism‐related genes. Indirect regulation involves STATs instructing genes encoding upstream or regulatory factors, including cytokine receptors and other transcription factors, as well as non‐canonical JAK‐STAT activities. Cytokines impact a vast range of metabolic processes. Here, we focus on those that are most prominent in T cells; lipid, amino acid, and nucleotide synthesis for anabolic metabolism, glycolysis, glutaminolysis, oxidative phosphorylation, and fatty acid oxidation for catabolic metabolism. Ultimately, we advocate the idea that JAK‐STAT is a key node in the complex network of signaling inputs and outputs which ensure that T cell metabolism meets lifestyle demands.
A Joint Study of Experimental and Computational Chemistry to Probe the Effect of Coordination Modes on the Luminescence of Uranyl‐Organic Coordination Polymers
Authors: Dai Yu‐Hao , Zhao Zhen , Wang Zi‐Xin , Liu Ning , Li Fei‐Ze , Su Jing 
Published: April 2023

AbstractDespite the potential application of uranyl‐organic coordination polymers (UOCPs) in detecting metal cations and radiation rays, their luminescence properties have not been sufficiently studied at the molecular level. Herein, we synthesized a series of UOCPs (UOCP1–9) with new construction based on bipyridinium salts and diverse auxiliary ligands. The physicochemical properties of the complexes with high purity were systematically characterized, especially the luminescence spectra. A deep theoretical investigation was conducted to illustrate the relation between uranyl coordination and the luminescence spectral property. The results show that the influence of ligand type on the uranyl luminescent spectral properties increases in the order of hydroxide>oxalate>aromatic carboxylate, which can be attributed to the magnitude of orbital interaction between uranyl and ligand. This work helps to profoundly understand uranyl optical properties and electronic structure at the molecular level, providing important hints for recognizing the nature of luminescent spectral features of uranyl‐containing materials, as well as the fundamental chemistry of actinide elements.
The economic impacts of cataract surgery on sustainable vision and quality of life in Katsina state
Authors: Rabiu Mansur M. , Taryam Manal O. , Yusuf Muhammad , Maji Ibrahim Kabiru 
Published: April 2023

AbstractBackgroundThis study investigates the economic impacts of eye care interventions on the quality of life in Katsina state. Eye care intervention is a requirement for equitable and inclusive development in the state.MethodsThe study used a survey method and 5‐point Likert scale questionnaire to collect data. A multistage sampling strategy was employed to select 300 beneficiaries from the existing beneficiaries of Noor Dubai Foundation (NDF) eye care interventions.ResultsThe findings show that cataract surgery interventions improve economic benefits and quality of life of beneficiaries in Katsina state. The results show that productivity, income, employability, dignity and skills of beneficiaries have improved significantly after the cataract surgery. Precisely, 96.2% of the beneficiaries agree that their productivity has improved; 99.6% of the beneficiaries revealed that their income has improved; 99% of respondents evidence that their employability has improved; 90% of beneficiaries have experienced an improvement in their dignity; while 97% agreed that their skills have improved.ConclusionThe implication of these findings is that poor eye health is negatively related to economic benefits and quality of life while good eye health is a vital determinant of standard of living. Without good eye health, it is hard to participate in the labour force, produce goods and earn income. Thus, the Katsina state government should further improve awareness of good eye health to mitigate preventable cases of blindness for equitable and inclusive development.
Refining prognosis in chronic lymphocytic leukemia with normal Fluorescence in situ hybridization results
Authors: Avenarius Matthew R. , Huang Ying , Hyak Jonathan , Byrd John C. , Bhat Seema A. , Grever Michael , Kittai Adam S. , Rogers Kerry A. , Jones Dan , Zhao Weiqiang , Heerema Nyla A. , Abruzzo Lynne V. , Woyach Jennifer , Miller Cecelia R. 
Published: April 2023

AbstractFluorescence in situ hybridization (FISH) to detect the recurrent cytogenetics abnormalities deletion 13q, trisomy 12, deletion 11q, and deletion 17p is important for prognostication in chronic lymphocytic leukemia (CLL). A subset of patients are negative for each of these abnormalities (normal 12/13/11/17 FISH), and outcomes are heterogenous within this group. To elucidate variables important for prognostication in this subgroup we conducted a retrospective analysis of 280 treatment‐naïve CLL patients with normal standard CLL FISH results. In a multivariable model, advanced Rai stage (p = 0.04, hazard ratio [HR] 1.24 (95% confidence interval [CI] 1.01–1.53)), unmutated immunoglobulin heavy chain gene (IGHV) (p < 0.0001, HR 5.59 (95% CI 3.63–8.62)) and IGH rearrangement by FISH (p = 0.02, HR 2.56 (95% CI 1.20–5.48)) were significantly associated with shorter time to first treatment. In a multivariable model for overall survival, increasing age at 5‐year increments (p < 0.0001, HR 1.55 (95% CI 1.25–1.93)), unmutated IGHV (p = 0.01, HR 5.28 (95% CI 1.52–18.35)) and gain of REL (p = 0.01, HR 4.08 (5% CI 1.45–11.49)) were significantly associated with shorter survival. Our study identifies variables important for refining prognosis for CLL patients with normal standard CLL FISH results.
Trichomonas vaginalis infection is associated with increased risk of cervical carcinogenesis: A systematic review and meta‐analysis of 470 000 patients
Authors: Hamar Balázs , Teutsch Brigitta , Hoffmann Eszter , Hegyi Péter , Váradi Alex , Nyirády Péter , Hunka Zsombor , Ács Nándor , Lintner Balázs , Hermánné Réka Juhász , Melczer Zsolt 
Published: April 2023

AbstractBackgroundTrichomonas vaginalis infection is the most prevalent non‐viral sexually transmitted infection (STI) in women and has been suggested as a risk factor for developing cervical cancer.ObjectiveWe aimed to investigate the associations between T. vaginalis infection and cervical carcinogenesis.Search StrategyA comprehensive systematic search was conducted in five databases on 21 October 2021.Selection CriteriaStudies assessing the relationship between T. vaginalis infection, HPV co‐infections, cervical dysplasia, and cervical cancer were found eligible.Data Collection and AnalysisSummary estimates for pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated with a random‐effects model. Statistical heterogeneity was measured with I2 and Cochran's Q tests.Main ResultsThe 29 articles included 473 740 women, of whom 8518 were T. vaginalis‐positive. Our results showed that T. vaginalis‐infected women had 1.79 times higher odds of being diagnosed with HPV co‐infection (95% CI 1.27–2.53; I2 95%). We also found that T. vaginalis infection was associated with high‐grade squamous intraepithelial lesion diagnosis (OR 2.34, 95% CI 1.10–4.95; I2 75%) and cervical cancer (OR 5.23, 95% CI 3.03–9.04; I2 3%).ConclusionsOur results showed an association between T. vaginalis and cervical carcinogenesis in sexually active women.
Ethnobotanical significance of medicinal plants: Beta‐amyloid and tau aggregation inhibitors against Alzheimer's disease
Authors: Ganapathy A. Anand , Haripriya Vijayakumari M. , Acharya Niyati , Somappa Sasidhar B. , Kumaran Alaganandam 
Published: April 2023

AbstractAmong the various neurodegenerative disorders, Alzheimer's disease (AD) is identified as one of primary causes of dementia in the elderly, which progresses slowly leading to cognitive decline and ability to function independently. Although various pathological mechanisms have been proposed, the exact mechanism is not yet elucidated. Numerous processes such as old age, mitochondrial dysfunction, and genetics lead to the aggregation of beta‐amyloid (Aβ) as amyloid plaques and tau proteins as neurofibrillary tangles in the neurons leading to their death and destruction, finally leading to AD. The current treatment measures can only temporarily improve the symptoms, slowing cognitive decline without any effect on AD pathology for better therapeutic effect. Furthermore, the high failure rates of a number of drugs during clinical trials due to their side effects has led the researchers to focus on alternative sources for drug development. As natural ingredients were considered the primary line of treatment in the olden days, and as several medicinal plant products are also proven as effective AD targets, it will be wise to investigate those with significant ethnobotanical value as potential neuroprotectives, nootropics or memory boosters. Throughout the study, propanoids, glycosides, iridoids, carotenoids and flavonoids that show potential anti‐inflammatory, antioxidant, and anti‐cholinesterase were also found to be inhibitors of Aβ and tau aggregation, where Saikosaponin C, Fisetin, and Morin can act as dual inhibitors. The review provides an insight in the need for proper and complete scientific evaluation of these ethnobotanically useful medicinal plants to be identified as potential leads in AD therapy.
Ameliorative effect of resveratrol against cymoxanil‐mancozeb induced toxicity in rats
Authors: Mohamed Wafaa H. , El‐Amir Yasmin O. , Yahia Doha 
Published: April 2023

AbstractThis study was conducted to evaluate the cymoxanil‐mancozeb (CM) toxicity and investigate the ameliorative effect of resveratrol (Res) against cymoxanil‐mancozeb toxicity. Forty rats were divided into four groups; the first group was used as a control group, the second group was exposed to Res only at a dose of 20 mg/kg body weight for 4 weeks, and the third group was administered CM only at a dose of 799 mg/kg body weight for 4 weeks, The fourth group was co‐treated with Res+CM for 4 weeks. Blood samples were analyzed for hematological and biochemical parameters. The comet assay was done on liver and blood specimens and histopathological examinations of the liver and intestine. The results demonstrated that CM exposure caused a significant increase in WBCs, lymphocytes, granulocytes, monocytes ALT, AST, ALP, and GGT, and total cholesterol and triglycerides levels accompanied by a decrease in HGB, HCT, RBCs and MCV, MCH, MCHC, HDL and glucose levels with no significant DNA damage in liver and blood. CM mixture induced severe pathological changes in small intestine and liver. Co‐treatment of Res with CM improved hematological picture, lipid and glucose profiles also liver enzymes and decreased changes in the architecture of the liver and intestine.
Molecular mechanisms of oxidative stress‐related neonatal jaundice
Authors: Perrone Serafina , Lembo Chiara , Giordano Maurizio , Petrolini Chiara , Cannavò Laura , Gitto Eloisa 
Published: April 2023

AbstractOxidative stress is a pathological condition characterized by an overload of oxidant products, named free radicals, which are not well counteracted by antioxidant systems. Free radicals induce oxidative damage to many body organs and systems. In neonatal red blood cells, free‐radical mediated‐oxidative stress leads to eryptosis, a suicidal death process of erythrocytes consequent to alteration of cell integrity. Neonatal red blood cells are targets and at the same time generators of free radicals through the Fenton and Haber‐Weiss reactions. Enhanced eryptosis in case of oxidative stress damage may cause anemia if the increased loss of erythrocytes is not enough compensated by enhanced new erythrocytes synthesis. The oxidative disruption of the red cells may cause unconjugated idiopathic hyperbilirubinemia in neonates. High levels of bilirubin are recognized to be dangerous for the central nervous system in newborns, however, many studies have highlighted the antioxidant function of bilirubin. Recently, it has been suggested that physiologic concentration of bilirubin correlates with higher antioxidant status while high pathological bilirubin levels are associated with pro‐oxidants effects. The aim of this educational review is to provide an updated understanding of the molecular mechanisms underlying erythrocyte oxidant injury and its reversal in neonatal idiopathic hyperbilirubinemia.