bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salting out, non-ideality and Synergism: how the Complex Chemical Composition of Atmospheric Aerosols Enhances Surfactant Efficiency
Authors: Noziere Barbara , Haber Manuella El , Ferronato Corinne , Fendler Anne Giroir , Fine Ludovic 
Published: August 2023

Abstract
In Earth’s atmosphere the efficiency of sub-micron aerosol particles to produce cloud droplets is expected to be affected by their surface tension. But this quantity cannot be measured directly and is inferred from the chemical compounds present in aerosols. Amphiphilic surfactants are present in aerosols but direct experimental information on the impacts of other aerosol components on their surface properties is lacking. This work explores systematically how NaCl, (NH4)2SO4, oxalic, and glutaric acid modify the surface properties of amphiphilic surfactants, SDS, Brij35, TritonX100, TritonX114, and CTAC, by determining the adsorption isotherms for these mixtures. The results reveal that all these water-soluble aerosol components enhance the efficiency of surfactants. The inorganic salts substantially lowered the surface tension (- Δσ > 10 mN m-1) and CMC of the surfactants by salting out while the surface tension of mixtures with organic acids deviated strongly from ideality (- Δσ = 10 - 30 mN m-1) and displayed some synergism. These results suggest that molecular interactions take place at the surface, even with non-ionic surfactants, that need to be further studied and included in models.
Hesperidin relieves irradiation-induced cognitive dysfunction via regulation of HMGB1-mediated neuroinflammation
Authors: Huang Wei , Xie Li , Ma Jun , Lu Hong , Chen Lejun , Yu Dahai , Yao Chang 
Published: August 2023

Abstract
Background: High mobility group box1 (HMGB1)is a chromatin-binding protein that especially regulates inflammatory signaling cascades. Several reports have demonstrated the anti-inflammatory effect of hesperidin. Whether hesperidin attenuates radiation-induced brain injury via inhibiting HMGB1-mediated neuroinflammation remains unclear.
Methods: Morris water maze test and the step-down passive avoidance test were applied to evaluate whether hesperidin could relieve the irradiation-induced cognitive dysfunction. Nissl staining, western blotting and immunofluorescence were performed to uncover the mechanisms.
Results: In this study, we found that radiation reduced the neuronal number and increased the content of the proinflammatory cytokines in the hippocampus, and hesperidin significantly reversed these changes. More importantly, hesperidin significantly improved the learning and memory abilities of X-ray-stimulated mice. We also found that radiation markedly increased Iba-1 expression in the hippocampus and resulted in substantial translocation of HMGB1 from the nucleus to the cytoplasm in the hippocampus and BV-2 cell, and hesperidin reversed the radiation-induced upregulation of Iba-1 and the cytoplasmic translocation of HMGB1. Moreover, hesperidin rescued the radiation-induced the upregulations in the phosphorylation levels of ERK, p38 and p65 in the hippocampus.
Conclusions: This study demonstrated that hesperidin alleviated the radiation-induced cognitive dysfunction via inhibiting HMGB-mediated neuroinflammation, and indicated that hesperidin could be a promising candidate for treatment of radiation- induced brain injury.
U2-Net_S Fire Smoke Segmentation Based on Multiscale Edge Fusion Convolutional Encoder and Edge Supervision
Authors: Zheng Yuanpan , Wang Hui , Gan Xinxin , Niu Liwei 
Published: August 2023

Abstract
The production of smoke is a sign of fire occurrence, and in the monitoring and prevention of disasters, the research value of smoke is higher than that of flames. Segmentation of smoke targets is of great significance for the study of smoke characteristics. However, traditional methods for smoke target segmentation are limited in accuracy and are easily affected by the scene. Existing smoke segmentation models rely on a large-scale classification backbone, which sacrifices high-resolution feature mappings to achieve deeper architectures. These models neglect the relatively important local details and global contrast information that are crucial for smoke segmentation, and their segmentation results for smoke edge details are also not satisfactory. In this paper, the Sobel operator and multi-scale convolutional encoder are fused for feature extraction, and the residual mixing attention mechanism as well as the edge segmentation module are added to the model, and a multi-scale segmentation model for fire smoke edge segmentation is proposed, which improves the segmentation accuracy, segmentation precision and edge segmentation. The test results of the homemade smoke segmentation dataset show that the model's mIoU can reach up to 90.48% and finally stabilized at 90.09%, mPA is up to 96.96%, MAE is reduced to 0.02, and MaxF1 reaches 94.37%, which is superior to the current semantic segmentation model. Compared with the base model U2-Net improves 3.26% (AVG20) and 2.68% (TOP1) in mIoU metrics, and 0.95% and 1.36% in mPA and MaxF1 metrics, respectively. The method proposed in this paper is more suitable for fire smoke segmentation, which is important for smoke characterization and smoke source point identification research.
"Selected fungicides as potential EDC estrogenic micropollutants in the environment"
Authors: Jabłońska-Trypuć Agata , Wydro Urszula , Wołejko Elżbieta , Makuła Marcin , Krętowski Rafał , Naumowicz Monika , Sokołowska Gabriela , Serra-Majem Lluis , Pasko Marzanna Cechowska – , Łozowicka Bożena , Kaczyński Piotr , Wiater Józefa 
Published: August 2023

Abstract
An increasing level of pesticides exposition is being observed as a result of the consumption of large amounts of fruit, vegetables and grain products, which are key components of the vegetarian diet. Fungicides have been classified as a endocrine-disrupting compounds, but their mechanisms of action have not yet been clarified. The effect of boscalid (B), cyprodinil (C) and iprodione (I) combined with Tamoxifen (T) and 17β-estradiol (E2) on cell viability, cell proliferation, reporter gene expression, ROS content, cell membrane’s function, cell morphology and antioxidant enzymes gene expression on MCF-7 and T47D-KBluc cell lines were investigated. Cell lines were chosen due to their response to 17β -estradiol. Selected fungicides are commonly used in Poland to protect crops against fungi. Our results revealed that studied fungicides caused significant increase in cell viability and proliferation and estrogenic activity was present in all studied compounds depending on their concentrations. Oxidative stress activated uncontrolled cancer cell proliferation by inducing ROS production and by inhibiting antioxidant defense. Our findings verified that studied fungicides could possibly exhibit endocrine disrupting properties and exposure should be avoided.
The impacts of tourist destinations on wildlife in northern Finland
Authors: Huhta Esa 
Published: August 2023

Abstract

The sprawl of tourism to natural areas may have many kinds of effects on wildlife species due to urban development, landscape fragmentation and increased disturbance. I examined potential effects of tourist destinations on four forest grouse and five mammalian species in northern Finland. I used density data coming from the late-summer and mid-winter wildlife counts. The data was collected in 88 wildlife triangles (length of 12 km each) within a radius of 40 km around ten tourist destinations in northern Finland conducted during 1989–2006 by hunters. The densities of the mountain hare (Lepidus timidus) and the mustelid species correlated negatively with the distance to a tourist destination. The density of adult grouse, juvenile grouse, mountain hare, and mustelids were positively correlated with the area of mixed forests surroundings of destinations. The densities of adult and juvenile grouses were positively and the density of pine marten and mustelids were negatively correlated with the area of agricultural land surroundings of destinations. The density of studied wildlife species varied between the destinations and the years. The results of the study suggest that the current recreation pressure has not caused substantial changes in the wildlife fauna in the surroundings of tourist destinations studied. The location of a destination, predator densities, and a landscape structure around destinations affected most the density of wildlife species.
Enhanced delivery of retinoic acid to breast cancer cells by folate receptor- targeted folic acid-conjugated glutenin nanoparticles for promising treatment of breast cancer
Authors: Rajeshkumar Raja Rajeswari , Pavadai Parasuraman , Panneerselvam Theivendren , Pandian Sureshbabu Ram Kumar , Kumar A. Santhana Krishna , Maszczyk Piotr , Babkiewicz Ewa , Kabilan Shanmugampillai Jeyarajaguru , Kunjiappan Selvaraj 
Published: August 2023

Abstract
Targeted delivery via surface receptors can significantly improve the therapeutic efficacy and reduce the adverse drug reactions. The protein nanocarrier system offers many advantages, such as encapsulation in various drugs and molecules and prolonged circulation. Here, the folate receptor-targeted folic acid-conjugated retinoic acid-loaded glutenin nanoparticles (FA-RA-Glu NPs) were successfully synthesised for enhanced delivery of retinoic acid to breast cancer cells (MCF-7). After a complete physico-chemical characterisation of FA-RA-Glu NPs, stability, drug release, release kinetics, cytotoxicity, apoptosis, cell death, and nucleic acid fragmentation were analysed. The results showed that FA-RA-Glu NPs were ⁓185 nm in size, predominantly spherical in shape, crystalline in nature and had a zeta potential of − 3 mV. The RA encapsulation efficiency and loading capacity of Glu NPs were 83.537% ± 3.32% and 9.917 ± 1.68%, respectively. The effects of FA-RA-Glu NPs against MCF-7 cells significantly reduced the number of viable cells and the induction of apoptosis. The cellular uptake study showed that the FA-RA-Glu NPs had facilitated endocytosis and delivered RA into MCF-7 cells. After treatment with FA-RA-Glu NPs, contracted nuclei and deformed membrane bodies were observed as typical apoptotic morphological changes. The released RA also targeted the mitochondria of MCF-7 cells, which significantly increased the levels of reactive oxygen species and contributed to the damage of mitochondrial membrane integrity. These results suggest that FA-RA-Glu NPs with facilitated endocytosis and targeted delivery of RA into MCF-7 cells may have significant therapeutic potential for the treatment of breast cancer.
Controllable synthesis of spherical S@CoMn2O4 battery-type electrode material for hybrid supercapacitors
Authors: Lv Xinrong , Min Xiaoqin , Liu Xuhui , Yang Changgui , Chen Jianyou , Lin Xiaoyun 
Published: August 2023

Abstract
A novel spherical Co-Mn composite -CoMn2O4 was synthesized via a one-step solvothermal method, and S doping CoMn2O4 (S@CoMn2O4) battery-type electrode material was further obtained via a hydrothermal vulcanization. This ion exchange technique is mainly carried out on the surface of the material and will not destroy the morphology of the original oxide-MOF, so the obtained materials generally have a core-shell structure. The S@CoMn2O4 not only remains a spherical character, but also possesses a coarser surface and porous structure, which considerably increases the specific surface areas (SSA) and electrochemical active sites (EAS) for electrode materials, thus facilitating the charge transfer kinetics for ions and electrons. When the current density (CD) is 1 A g-1, the specific capacity (Cs) of S@CoMn2O4 is 812 C g-1. Moreover, S@CoMn2O4 has excellent electrochemical cycling performance, and the retention rate of Cs for the S@CoMn2O4 reach 92.91% after 5000 cycles at 10 A g-1. When the specific power (Ps) is 775 W kg-1, the specific energy (Es) for S@CoMn2O4//AC device reaches 44.36 Wh kg-1.
Residual pattern of the hyperintense area on T2-weighted magnetic resonance imaging after initial treatment predicts the pattern and location of recurrence in patients with newly diagnosed glioblastoma
Authors: Shimoda Yoshiteru , Kanamori Masayuki , Yamashita Shota , Shibahara Ichiyo , Umezawa Rei , Mugikura Shunji , Jingu Keiichi , Saito Ryuta , Sonoda Yukihiko , Kumabe Toshihiro , Endo Hidenori 
Published: August 2023

Abstract
Purpose: This study aimed to investigate the clinical significance of residual hyperintensity on T2-weighted magnetic resonance imaging in patients with glioblastoma (GB) without enhanced lesions at the end of initial treatment with debulking surgery and concomitant radiotherapy and temozolomide.
Methods: Among 185 GB cases, 80 cases without enhanced lesions at the end of initial treatment and without factors modifying the distribution of residual hyperintense area or pattern of recurrence were included. We retrospectively reviewed the relationship of residual hyperintense area after initial treatment with progression-free survival (PFS), overall survival (OS), and pattern of recurrence.
Results: In these 80 cases, the median PFS and OS were 12.0 and 37.5 months, respectively. At the end of initial treatment, 53 (66.3%) cases had residual hyperintense lesions (T2 residual group, T2R), whereas 27 (33.8%) showed no hyperintensity (T2 vanished group, T2V). Based on univariate and multivariate analyses, the residual hyperintense area after initial treatment was not a prognostic factor for PFS or OS. Distant recurrences occurred more frequently in the T2V group than in the T2R group (47.6% vs. 12.8%). In the T2R group, the recurrence site coincided with the residual hyperintense area in 32 (80.0%) of 40 recurrences.
Conclusion: In GB cases without enhanced lesions at the end of initial treatment, the complete disappearance of the residual hyperintense area after initial treatment does not indicate a favorable outcome. Additionally, distant recurrences should be considered in T2V group and local recurrences should be considered in T2R group.
A new look at acute kidney injury in human visceral leishmaniasis: the relationship with circulating immune complexes
Authors: Corrêa-Castro Gabriela , Silva-Freitas Maria Luciana , Paula Ludmila , Soares Leonardo , Dutra Maria Rita Teixeira , Albuquerque Hermano Gomes , Cota Glaucia , Martins Caroline Azevedo , Da-Cruz Alda Maria , Gomes-Silva Adriano , Santos-Oliveira Joanna Reis 
Published: August 2023

Abstract

Visceral leishmaniasis (VL) is an infectious disease caused by Leishmania infantum. Clinically, VL evolves with systemic impairment, immunosuppression and hyperactivation with hypergammaglobulinemia. Although renal involvement has been recognized, a dearth of understanding about the underlying mechanisms driving acute kidney injury (AKI) in VL remains. We aimed to evaluate the involvement of immunoglobulins (Igs) and immune complexes (CIC) in the occurrence of AKI in VL patients. Fourteen VL patients were evaluated between early treatment and 12 months post-treatment (mpt). Anti-Leishmania Igs, CIC, cystatin C, C3a and C5a were assessed and correlated with AKI markers. Interestingly, high levels of CIC were observed in VL patients up to 6 mpt. Concomitantly, twelve patients met the criteria for AKI, while high levels of cystatin C were observed up to 6 mpt. Plasmatic cystatin C was positively correlated with CIC and Igs. Moreover, C5a was correlated with cystatin C, CIC and Igs. We did not identify any correlation between amphotericin B use and kidney function markers in VL patients, although this association needs to be further explored in subsequent studies. Our data reinforce the presence of an important renal function impairment during VL, suggesting the involvement of Igs, CIC, and C5a in the clinical condition.
Construction of Financial Risk Pre-alarm Index System in Refractory Industry
Authors: Jin Yingying 
Published: August 2023

Abstract
Refractory materials are important basic materials for high-temperature industries such as steel, nonferrous metals, building materials, petrochemicals, environmental protection and electric power. Due to the continuous downturn in the business performance of upstream and downstream industries, the speed of capital return has decreased, and the capital chain of refractory companies may be broken. Therefore, it is imperative to build a financial risk pre-alarm system for refractory companies and strengthen related research on financial risk pre-alarm of refractories. In order to solve the difficulties that the traditional financial risk pre-alarm model is difficult to deal with highly nonlinear models and lacks adaptive ability, this article applies sparse noise reduction self-coding neural network (SDAE-NN) to the financial risk pre-alarm system of refractory industry, and constructs the financial risk pre-alarm model of refractory industry. Due to the serious overcapacity of China iron and steel, and most of them are low-end products, most enterprises are in a state of loss, and they are considering transformation and development, and the refractory enterprises that provide products and services for them have also been greatly impacted. In order to ensure the stability of macro-economy and the healthy and effective operation of enterprises, it is of great practical significance to innovate and construct financial management theory, establish financial risk pre-alarm mechanism and accurately identify crisis signals to predict financial risks of enterprises.
Quercetin protects cadmium-induced renal injury in mice by inhibiting pyroptosis
Authors: wang juyu , Yang Jieyan , Liu Kai , Zhang Limei , Qu Weijie , Wang Kun , Zhao Yu , Zhou Yaxiong , Liu Xiang , Gu xiaolong , Wang Shengkui 
Published: August 2023

Abstract
The heavy metal pollutant cadmium (Cd) is frequently found in the environment and is highly toxic, particularly affecting the kidneys. It remains unclear whether the non-toxic flavonoid quercetin can counteract Cd-induced renal pyroptosis. In this study, we established a model of cadmium poisoning treated with quercetin both in vitro (using mouse renal MES-13 cells at a concentration of 5 µM for 24 h) and in vivo (10 Kunming mice receiving 1 mg/kg body weight via oral gavage for 4 weeks). In vitro experiments revealed that cell viability significantly decreased after exposure to different concentrations of Cd for 12h and 24h, following a concentration-time dependent pattern. Furthermore, treatment with Cd led to a significant increase in cleaved caspase-1, NLRP3, and IL-1β protein levels in MES-13 cells (P < 0.01), which was effectively alleviated by quercetin treatment. In vivo studies demonstrated that Cd significantly elevated blood urea nitrogen levels while reducing GPX and SOD levels. Pathological sections revealed tubular stenosis and renal interstitial congestion as characteristic damage caused by Cd exposure. Notably, Cd-induced renal cell pyroptosis protein cleaved caspase-1 was significantly increased, however, quercetin administration could mitigate these injuries induced by Cd exposure through decreasing caspase-1 protein expression and inhibiting renal cell pyroptosis. Collectively, our findings indicate that kidney cells are susceptible to pyroptotic cell death due to Cd exposure possibly mediated by ROS production leading to oxidative cellular damage followed by activation of caspase-1; meanwhile, quercetin exhibits protective effects against kidney injuries induced by Cd through inhibition of kidney cell pyroptosis.
Octoploids show enhanced salt tolerance through chromosome doubling in Switchgrass (Panicum virgatum L.)
Authors: Fan Yupu , Ye Jiali , Zhang Hui , Yin Lina , Teng Wenjun , Teng Ke , Wu Juying , Fan Xifeng , Wang Shiwen , Yue Yuesen 
Published: August 2023

Abstract
Background Polyploid plants often exhibit enhanced stress tolerance. Switchgrass is a perennial rhizomatous bunchgrass that is considered ideal for cultivation in marginal lands, including sites with saline soil. In this study, we investigated the physiological responses and transcriptome changes of octoploid and tetraploid of switchgrass (Panicum virgatum L. ‘Alamo’) under salt stress.Results We found that autoploid 8× switchgrass had enhanced salt tolerance compared with the amphidiploid 4× precursor as indicated by physiological and phenotypic traits. Octoploids had increased salt tolerance by significantly changes to the osmoregulatory and antioxidant systems. The salt-treated 8× Alamo plants showed greater K+ accumulation and an increase in the K+/Na+ ratio. Root transcriptome analysis for octoploid and tetraploid plants with or without salt stress revealed that 302 upregulated and 546 downregulated differentially expressed genes were enriched in genes involved in plant hormone signal transduction pathways, and were specifically associated with the auxin, cytokinin, abscisic acid, and ethylene pathways. Weighted gene co-expression network analysis detected four significant salt stress-related modules.Conclusions This study explored the changes in the osmoregulatory system, inorganic ions, antioxidant enzyme system, and the root transcriptome in response to salt stress in 8× and 4× Alamo switchgrass. The results enhance knowledge of the salt tolerance of artificially induced homologous polyploid plants, and provide experimental and sequencing data to aid research on the short-term adaptability and breeding of salt-tolerant biofuel plants.
Shunt Resistance Optimized Indoor Photovoltaic System for Powering Internet of Things
Authors: Xue Shujian , Yang Guangan , Zhao Xing , Wu Jianfei , Li Run , Li Binhong , Xu Yong 
Published: August 2023

Abstract
This article proposes a photovoltaic system of ultrathin silicon solar cell by using indoor lighting through enhanced shunt resistance, nanostructure of light-trapping, and tubular daylight system for powering the internet of things (IoT) devices. Simulation results show that, by increasing the shunt resistance from 100 Ω.cm2 to 104 Ω.cm2, the efficiency of indoor solar cell can be improved from less than 0.5% to be over 14%. Moreover, with the help of ultrathin wafer and nanostructure of light-trapping to improve the near-infrared light absorption and open circuit voltage, the efficiency of the indoor amorphous silicon (a-Si) heterojunction solar cell can be further improved to be 17.09%. The tubular daylight system is an excellent supplement to the light indoor intensity and thus can increase the power production.
Green synthesis of novel pyrazole carbonitrile and aryl methylene-pyrazole derivatives using 2-aminopyridine-Functionalized Silica-Coated Fe3O4 Nanoparticles as a highly-efficient and magnetically Separable Catalyst (Fe3O4@SiO2/NH/CC/2APy/CuII)
Authors: liwal abdulqader , Akbarpour Tahereh , khazaei adeshir , Ghanbarpour Amir 
Published: August 2023

Abstract
A novel catalyst namely, Fe3O4@SiO2/Si(OEt)(CH2)3NH/CC/2-aminopyridine/Cu(OAc)2, abbreviated (Fe3O4/SiO2/NH/CC/2APy/CuII) was designed and prepared. In this study, we show that Copper(II) acetate complex-based 2-amino pyridine coated on Fe3O4 magnetic nanoparticles as an effective and Magnetically Separable nanocatalyst by a low-cost and simple procedure. The morphology and structure of Fe3O4/SiO2/NH/CC/2APy/CuII were studied and characterized using several techniques. Nanocatalysts synthesized (Fe3O4/SiO2/NH/CC/2APy/CuII) in very simple ways are separated by an external magnet for five runs, according to the results, no significant reduction in reaction yields was observed. Catalytic studies revealed that the Fe3O4/SiO2/NH/CC/2APy/CuII catalyst is a highly efficient and green nanocatalyst for the synthesis of pyrazole carbonitrile and aryl methylene-pyrazol. The use of synthetic catalyst in this method has many advantages, including high efficiency, simple method, short reaction time, and easy recovery of the catalyst.