bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall survival with frontline vs subsequent anti-epidermal growth factor receptor therapies in unresectable, RAS/BRAF wild-type, left-sided metastatic colorectal cancer
Authors: Pakvisal Nussara , Goldberg Richard M , Sathitruangsak Chirawadee , Silaphong Witthaya , Faengmon Satawat , Teeyapun Nattaya , Teerapakpinyo Chinachote , Tanasanvimon Suebpong 
Published: January 2025

BACKGROUND
The combination of anti-epidermal growth factor receptor (EGFR) therapy and chemotherapy is currently a preferred first-line treatment for patients with unresectable, RAS and BRAF wild-type, left-sided metastatic colorectal cancer (mCRC). Several studies have also demonstrated the benefit of anti-EGFR therapy in subsequent line settings for this patient population. However, direct evidence comparing the effectiveness of frontline vs subsequent anti-EGFR therapy remains limited, leaving a crucial gap in guiding optimal treatment strategies.
AIM
To compare overall survival (OS) between frontline and subsequent anti-EGFR treatment in patients with unresectable, RAS and BRAF wild-type, left-sided mCRC.
METHODS
We retrospectively reviewed the medical records of mCRC patients treated at The King Chulalongkorn Memorial Hospital and Songklanagarind Hospital, Thailand, between January 2013 and April 2023. Patients were classified into two groups based on the sequence of their anti-EGFR treatment. The primary endpoint was OS.
RESULTS
Among 222 patients with a median follow-up of 29 months, no significant difference in OS was observed between the frontline and subsequent-line groups (HR 1.03, 95%CI: 0.73-1.46, P = 0.878). The median OS was 35.53 months (95%CI: 26.59-44.47) for the frontline group and 31.60 months (95%CI: 27.83-35.37) for the subsequent-line group. In the subsequent-line group, 71 patients (32.4%) who ultimately never received anti-EGFR therapy had a significantly worse median OS of 19.70 months (95%CI: 12.87-26.53).
CONCLUSION
Frontline and subsequent-line anti-EGFR treatments provide comparable OS in unresectable, RAS/BRAF wild-type, left-sided mCRC patients, but early exposure is vital for those unlikely to receive subsequent therapy.
Residual gastric cancer with a mixed small cell neuroendocrine and keratinizing squamous cell carcinoma: A case report
Authors: Wang Tian , Cheng Yang , Hu Fan , Wang Qiang 
Published: January 2025

BACKGROUND
Despite advancements in early detection and treatment, the prognosis and histological types for residual gastric cancer (GC) remains poor.
CASE SUMMARY
This case report presents a rare occurrence of residual GC featuring a combination of small cell neuroendocrine carcinoma (SCNEC) and squamous cell carcinoma (SCC) in a 60-year-old male patient. The patient, with a history of Billroth II gastrectomy for duodenal ulcer bleeding, presented with gastrointestinal bleeding. Preoperative computed tomography and positron emission tomography-computed tomography indicated adenocarcinoma with tumor and abdominal lymph node metastasis. The patient underwent laparoscopic total gastrectomy and lymph node dissection for residual GC. Histological examination of the resected tumor confirmed the presence of both SCNEC and SCC. Postoperatively, the patient underwent adjuvant chemotherapy four times. Two years later, the patient was found to occur esophageal cancer and was performed a small bowel stoma and radical esophagectomy.
CONCLUSION
In this case report, we detail a rare instance of residual GC with mixed SCNEC and SCC, emphasizing the complexity of diagnosis and treatment, and the need for ongoing research.
Efficacy of disitamab vedotin-containing therapy in metastatic colorectal cancer: A case report
Authors: Yan Hu-Cheng , Liu Yan , Feng You , Li Jun-Ming , Sheng Lei-Ming , Chen Xin , Xie Yu-Ping , Li Na 
Published: January 2025

BACKGROUND
Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. In cases of metastatic CRC (mCRC) that are resistant to conventional chemotherapy-based treatments, the efficacy of available therapeutic options is typically low. CRC exhibiting overexpression or amplification of the human epidermal growth factor receptor 2 (HER2) gene has shown responsiveness to HER2-targeted therapies.
CASE SUMMARY
We present the case of a 69-year-old woman diagnosed with mCRC with an NRAS p.G12V mutation and microsatellite stability, identified through tumor sequencing, along with HER2 overexpression detected by immunohistochemistry. She exhibited an excellent response to disitamab vedotin-containing therapy. To our knowledge, this is the first reported case of mCRC with HER2 overexpression and an NRAS p.G12V mutation achieving a remarkable clinical response to anti-HER2 therapy.
CONCLUSION
Disitamab vedotin demonstrates promising anti-tumor effects in HER2-overexpressing mCRC, offering patients an additional treatment option.
Community Policing: “Atalakpa” (Edo State Security Network) and the Management of Crime and Internal Security in Edo State, Nigeria
Authors: Idowu Olusegun Oladele , Usifoh Destiny Ebatamaehi Usifoh 
Published: January 2025

This study assessed the praxis of community policing in managing internal security in Edo State, Nigeria. It also evaluated the nature of community policing (Atalakpa-Edo State Security Network) in Edo State and its effectiveness. In addition, the study identified the relationship between community policing (Atalakpa-Edo State Security Network) and the public security force in Edo state. The study further Identified the challenges confronting Atalakpa-Edo State Security Network in Edo State. The study employed survey research design, using both quantitative and qualitative research methods. Also, both primary and secondary data were explored. The data collected were analysed using descriptive statistics involving frequency counts, percentages, mean scores and charts. The findings showed that the government falls short of effectively providing security for the citizens; hence, the community opted for Atalakpa community policing, which is focused on fostering greater trust and cooperation between the police and the residents geared towards maximising police resources through community participation in public safety initiatives. The study concluded that the emergence of community policing (Atalakpa-Edo State Security Network) was borne out of the need to reduce crimes and social vices, security of lives and properties, and to complement other security agencies in fighting crime and criminality in rural areas. The study recommends restructuring and overhauling of the Atalakpa- Edo State Security Network to meet its establishment's goals and purpose. Also, there should be better collaboration and partnership between community policing and other security agencies in the area of handing-over/transporting of suspects, conducting investigation, sharing of information, fire alert, armed patrol, joint duty posting, training and re-training; workshops and seminars, with a view to fighting crime and criminality, and entrenching peace in rural areas.
Acheloo nelle monete di Neapolis: un mito moderno?
Authors: Carroccio Benedetto 
Published: January 2025

Nell'ultimo secolo si è diffusa l'idea che, almeno a Neapolis, il toro dalla testa umana - frequentemente raffigurato sulle sue monete - rappresentasse Acheloios, il dio fluviale dell'Acarnania, noto per la sua battaglia con Eracle. Questa interpretazione si è basata su fonti più tarde che suggerivano che Acheloios fosse il padre della sirena Partenope, la dea eponima della città precedente a Neapolis, che secondo molti era raffigurata sul dritto di quelle monete. Tuttavia, è stato recentemente obiettato che la rappresentazione di Partenope come sirena è emersa dopo la coniazione di queste monete e che la figura femminile sulle monete, indipendentemente dal suo nome, mostra le caratteristiche iconografiche di una ninfa, la dea sovrana delle città-stato, senza il corpo alato tipico delle sirene. Inoltre, non ci sono prove di un culto dedicato ad Acheloios nella Neapolis greca. L'identificazione del toro con testa umana sulla monetazione di Neapolis sembra derivare da una modifica temporanea del tipo, avvenuta al tempo di Ermocrate in diverse zecche siciliane. Questa variante presentava una testa giovanile con piccole corna, che compariva anche su due oboli di Neapolis, accompagnata da un'iscrizione che identificava la figura come Sepethos, il fiume della città. Questa è abbinata all'immagine di una dea alata che tiene in mano un'idria, probabilmente una ninfa - forse la dea Sebethis, conosciuta attraverso le fonti letterarie.
Analisis Framing dalam Pemberitaan Penundaan Pemilu 2024 di Tribun-Timur.com
Authors: Nizam Muh Sahrul , Rina Diana , Manggaga Indah Pratiwi 
Published: January 2025

Penundaan pemilu 2024 banyak disoroti media, terutama media online. Tribun-Timur.com merupakan salah satu media online yang banyak memuat berita terkait penundaan pemilu 2024. Pemberitaan penundaan pemilu 2024 gencar dilakukan Tribun-Timur.com pada saat mendekati Pemilu berlangsung hingga pemilihan serentak di Indonesia. Dalam pemberitaannya, Tribun-Timur.com menggambarkan banyak hal tentang penundaan pemilu 2024, di antaranya penundaan pemilu 20224 yang dilakukan Bahlil dan Luhut Binsar Panjaitan dengan statementnya dan tanggapan beberapa pakar politik.
Penelitian ini bertujuan untuk mengetahui bagaimana Tribun-Timur.com membingkai pemberitaan penundaan pemilu 2024 dengan menggunakan analisis Framing model Robert N Entman. Hasil penelitian menunjukkan Tribun-Timur.com lebih informatif dan mencoba menggiring opini publik dengan menampilkan perbedaan hasil tanggapan penundaan pemilu 2024. Beberapa tanggapan yang berbeda bagaimana statement Bahlil dan Luhut Binsar Panjaitan yang ingin melakukan penundaan pemilu 2024 dan mendapatkan penolakan dari masyarakat pakar politik.
Conhecimento de pais e responsáveis sobre manobras de desengasgo no recém-nascido durante a amamentação: uma revisão de escopos
Authors: Santos Juliana Rodrigues dos , Carvalho Elis Frausto , Goldoni Esdra Cristina Pereira , Alberti Gabriela , Oliveira Leticia de , Faria Evellyn Lorenna Garcia Pinheiro de , Costa Sara Eleotério , Bortoloci Jhennifer Galassi , Sanches Rafaely de Cassia Nogueira , Uema Roberta Tognollo Borotta , Ichisato Sueli Mutsumi Tsukuda 
Published: January 2025

Introdução: O engasgo é definido quando ocorre uma obstrução das vias aéreas por algum objeto, ou substância, com maior risco quando penetra nos pulmões. Pode acontecer em qualquer faixa etária, sendo mais frequente na população infantil. Em lactentes é possível transcorrer durante a amamentação e se não for feita uma intervenção rápida pode levar ao óbito. Por isso o conhecimento sobre a manobra de desengasgo é de extrema importância para pais e familiares, cabendo ao enfermeiro esse papel de educação em saúde. Objetivo: explorar na literatura o conhecimento de pais e responsáveis sobre manobras de desengasgo no recém-nascido durante o aleitamento materno. Método: trata-se de uma revisão de escopo. A busca de artigos foi realizada nas bases de dados MEDLINE via PubMed, LILACS via Biblioteca Virtual de Saúde (BVS), IBECS e Google Acadêmico, em um período de 2018 até 2023. Resultados: foram encontrados um total de 142 artigos e após critérios de inclusão e exclusão restou uma amostra final de quatro artigos. Conclusão: é necessário educação preventiva para com os pais e familiares de bebês, lactentes e crianças quanto as manobras de desengasgo, de Heimilich e técnicas de primeiros socorros. A capacitação neste tema deve ser feita tanto para pessoas leigas quanto para os profissionais.
Percepção de mulheres sobre o exame citopatológico na consulta de enfermagem ginecológica
Authors: Timm Ana Paula , Corrêa Claudelí Mistura , Schons Andressa Karine , Damião Ronize Peruzzi , Huppes Betânia 
Published: January 2025

Esta pesquisa tem como objetivo conhecer a percepção de mulheres sobre a realização do exame citopatológico (CP) na consulta de enfermagem ginecológica. Trata-se de uma pesquisa descritiva, de abordagem qualitativa, realizada em uma Unidade Básica de Saúde de um município do Rio Grande do Sul, Brasil, com a participação de 11 mulheres com idade entre 26 e 61 anos, as quais realizaram o CP na consulta de enfermagem ginecológica. A coleta dos dados ocorreu por meio de entrevistas semiestruturadas com questões abertas, submetidas à Análise de Conteúdo modalidade Temática. A partir da análise dos dados emergiram duas categorias temáticas, sendo elas: A representatividade da consulta de enfermagem ginecológica e a percepção do CP para as mulheres; e As dificuldades vivenciadas pelas mulheres para realizar o CP. A percepção das mulheres em relação à consulta de enfermagem ginecológica foi caracterizada pela realização do CP, exame clínico das mamas, testes rápidos de infecções sexualmente transmissíveis, acolhimento e escuta qualificada do profissional enfermeiro. Identificaram-se aspectos dificultadores para a adesão e realização do exame, tais como: a dor, a vergonha e o desconforto. Conclui-se sobre a necessidade de ações de educação em saúde com as mulheres, com finalidade de fortalecer o empoderamento, fomentar o autocuidado feminino, com ênfase na saúde sexual e reprodutiva, e o reconhecimento dos afazeres do profissional enfermeiro.
ESTRATÉGIAS PARA GESTÃO DOS CONFLITOS ENTRE PROFISSIONAIS DA SAÚDE E SEU IMPACTO NA QUALIDADE DO ATENDIMENTO: REVISÃO INTEGRATIVA
Authors: Ferreira Sonia Maria Isabel Lopes , Ferreira Maria do Rosário Andrade Barreto , Souza Karine Andrade Britto de , Oliveira Noelia Silva , Oliveira Sharon Shyrley Weyll 
Published: January 2025

Quando duas ou mais pessoas apresentam diferentes opiniões, que resultam em discordâncias externas ou internas, há ocorrência de conflitos. É impossível evitar sua ocorrência, contudo, estes precisam ser adequadamente gerenciados para que não atrapalhem o processo de trabalho. Este estudo consiste em uma Revisão Integrativa da Literatura, com busca realizada no portal da Biblioteca Virtual em Saúde, Pubmed, Scielo e Scopus. A partir dos estudos encontrados, foi realizada análise qualitativa dos mesmos por meio da Análise de Conteúdo de Bardin. Foram incluídos 13 estudos de variados países, e, após análise, foram estabelecidas três categorias temáticas: “Os tipos de conflitos e seus fatores causais”, “Estratégias para Gestão de Conflitos” e “Consequências dos Conflitos”. Concluiu-se que a ocorrência de conflitos é esperada em qualquer local em que existam duas ou mais pessoas e, nos serviços de saúde, a complexidade do ambiente é um fator que predispõe ao seu aparecimento. A escolha da estratégia para gestão de conflitos varia de acordo com a personalidade e experiência do profissional.
Self-medication practice among dental students: associated factors and risks
Authors: Sandoval Zenzano Solange , Fuentecilla Nancy Lidia , Grandinetti José Alberto 
Published: January 2025

Introduction: Self-medication, defined as the use of medications without medical prescription, is a widespread practice in the general population and particularly among students of health-related careers, such as Dentistry. This phenomenon is associated with factors such as the perceived mildness of symptoms, recommendations from family or friends, and easy access to medications. The study analyzed the prevalence, the most commonly used drugs and the consequences of this practice among students of the Universidad Abierta Interamericana (UAI). Development: It was identified that the drugs most commonly used in self-medication were nonsteroidal anti-inflammatory analgesics (NSAIDs) and antibiotics. NSAIDs, used for the management of pain and inflammation, presented associated risks, such as renal and gastrointestinal damage. Antibiotics, on the other hand, were the most worrying due to the development of microbial resistance, a growing problem that affects the effectiveness of medical treatments. In addition, self-medication was linked to the lack of medical supervision, the influence of advertising, and insufficient knowledge of the risks associated with the irrational use of drugs. Conclusions: Self-medication turned out to be a prevalent and worrying practice among dental students of the UAI, generating risks at the individual and collective level. It was concluded that it is necessary to implement educational and regulatory interventions that promote the rational use of drugs and raise awareness of their possible consequences. The strengthening of vigilance in the distribution and prescription of drugs was highlighted as a fundamental strategy to mitigate the adverse effects of this behavior
Exploring the limits: reproductive rights and biotechnology in the modern era
Authors: Bohórquez Rivera Danny Stuart , Almagro Córdova Stephanie Alejandra , Suaste Pazmiño Denisse Isabel 
Published: January 2025

This paper explores the intersection between reproductive rights and biotechnology in the context of the modern era. Objective: To determine the bioethical dilemmas associated with reproductive rights in biotechnology-driven procedures Methodology: This is a literature review using a PRISMA diagram in which 12 articles were analyzed. Results: Significant benefits were identified in the use of assisted human reproduction techniques (AHR), especially in couples with sterility or infertility problems. In addition, the need to establish a solid ethical and legal framework to protect the rights and dignity of all persons involved in reproductive biotechnological processes was identified. Conclusion: While there are potential benefits to expanded access to assisted reproductive technologies and genetic manipulation, there are also significant ethical and social concerns that require careful and deliberate attention
REFLEKSI FILOSOFIS TRANSFORMASI MENUJU MASYARAKAT TERBUKA: WAWASAN LIBERALISME INDONESIA PERSPEKTIF FRANCIS FUKUYAMA
Authors: Marianus Elki Semit  , Pius Pandor  
Published: January 2025

Fokus tulisan ini membahas transformasi menuju masyarakat terbuka di Indonesia melalui perspektif liberalisme menurut Francis Fukuyama. Kajian ini bertujuan untuk mengeksplorasi sejauh mana pemikiran Fukuyama dapat menjadi landasan teoretis bagi perubahan masyarakat Indonesia. Perihal gagasan Fukuyama diharapkan memberikan pandangan kritis terhadap relevansi dan kontribusinya terhadap proses transformasi tersebut. Implementasi liberalisme di Indonesia menghadapi tantangan signifikan, termasuk kekuasaan pemerintah yang cenderung otoriter dan membatasi kebebasan masyarakat. Kondisi ini memperlambat pergerakan menuju kesejahteraan individu maupun kolektif. Fukuyama menawarkan potensi dampak positif bagi Indonesia, meski harus melalui proses panjang dan menghadapi berbagai hambatan. Transformasi ini menuntut tindakan nyata untuk membangun negara yang lebih terbuka dan menjunjung tinggi nilai-nilai deliberatif. Tulisan ini menggunakan metode tinjauan kepustakaan untuk menganalisis relevansi dan implikasi gagasan Fukuyama dalam konteks Indonesia. Pemetaan analisis transformasi menuju masyarakat terbuka serta memberikan rekomendasi untuk mengoptimalkan potensi perubahan tersebut demi masa depan Indonesia yang lebih baik.
EKSISTENSI MORI KRAENG PADA MASYARAKAT MANGGARAI DALAM PERSPEKTIF TRANSENDENSI KARL JASPERS
Authors: Fransiskus Bala Kleden  , Silfanus Jemadin  , Yohanes Baptista Angelino Galus  , Bernardus Subang Hayong  
Published: January 2025

Artikel ini bertujuan membahas eksistensi Mori Kraeng dalam perspektif filsafat Karl Jaspers. Dalam tradisi dan kepercayaan masyarakat Manggarai, Mori Kraeng dianggap sebagai entitas transenden, wujud tertinggi dan pengatur kehidupan. Tujuan dari penulisan artikel ini ialah menjelaskan eksistensi Mori Kraeng dengan mengacu pada pemikiran Jasppers tentang Transendensi. Untuk mencapai tujuan ini, penelitian kualitatif dengan metode studi kepustakaan digunakan untuk menelusuri buku-buku dan artikel-artikel jurnal sebagai sumber primer dan sumber sekunder. Hasil yang ditemukan dalam penulisan artikel ini ialah pemikiran Jaspers tentang Transendensi, yang menyatakan bahwa pengalaman Transendensi terjadi dalam situasi batas dan tidak dapat dijelaskan sepenuhnya oleh akal, sejalan dengan cara masyarakat Manggarai berhubungan dengan Mori Kraeng. Dalam pandangan ini, kepercayaan terhadap Mori Kraeng bukan hanya menyentuh aspek budaya, melainkan juga berkenaan dengan sebuah pencarian eksistensial yang memberi makna dan arah hidup, terutama dalam menghadapi keterbatasan hidup, seperti penderitaan dan kematian. Simbolisme adat, seperti ritual syukur dan persembahan, menjadi jembatan untuk menghubungkan manusia dengan Mori Kraeng, yang merupakan realitas yang melampaui dunia imanen.
MENINGKATKAN PARTISIPASI ORANG MUDA KATOLIK DALAM BERKATEKESE MENGGUNAKAN MEDIA AUDIO VISUAL
Authors: Anastasia Fautina Pale  , Alfonsus Mudi Aran  , Yosep Belen Keban  
Published: January 2025

Masalah utama dalam penelitian ini adalah bagaimana partisipasi OMK dalam berkatekese dengan menggunakan media audio visual. Tujuan dari penelitian adalah untuk mengetahui partisipasi OMK dalam berkatekese menggunakan media audio visual. Penelitian ini menggunakan pendekatan deskriptif. Lokasi dan waktu penelitian ini terjadi di Kuasi Paroki Santo Simon Petrus Anaranda pada bulan Februari 2024 sampai Juni 2024. Obeservasi, wawancara dan studi dokumentasi sebagai teknik pengumpulan data. Subyek penelitian ini berjumlah 20 orang dan data tersebut diperoleh dari 7 informan. Teknik analisis data dalam peneitian yaitu data-data yang dilakukan ditemukan di lapangan akan dikaji dan dijelaskan secara terperinci sehingga dapat dimenciptakan suatu konsep atau penarikan kesimpulan tentang Meningkatkan Partisipasi Orang Muda Katolik Dalam Berkatekese Malalui Media Audio Visual di Kuasi Santo Simon Petrus Anaranda. Pengolahan dan analisis dilakukan dengan menggunakan reduksi data, penyajian data dan kesimpulan. Hasil penelitian menunjukan bahwa partisipasi Orang Muda Katolik dalam berkatekese menggunakan media audio visual di Kuasi Paroki Santo Simon Petrus Anaranda dalam hal shering pengalaman, menyampaikan pendapat, menjawab pertanyaan, semangat serta melakukan aksi nyata semakin baik dan meningkat. Dengan demikian Orang Muda Katolik dapat memanfaatkan media audio visual sebagai alat bantu dalam berkatekese, dan dapat meningkatkan partisipasi mereka.
PERWUJUDAN KOINONIA DALAM MEMBANGUN MODERASI BERAGAMA BAGI KAUM MUDA KATOLIK
Authors: Yovita Ina Peni B. Y.  , Benedikta Yosefina Kebingin  , Alfonsus Mudi Aran  
Published: January 2025

Moderasi dewasa ini menjadi perbincangan yang serius untuk mewujudkan kedamaian dalam hidup bersama di tengah umat yang memilik perbedaan satu dengan yang lainya. Dengan adanya perbedaan maka perwujudan semangat koinonia dapat membangun moderasi beragama bagi Orang Muda Katolik di Paroki St. Kornelius Pohon Bao, Keuskupan Larantuka. Tujuan dari penelitian ini adalah untuk mengetahui Pemahaman OMK Paroki St. Kornelius Pohon Bao, Keuskupan Larantuka tentang Koinonia dan moderasi beragama dan dampak dari perwujudan Koinonia untuk membangun moderasi beragama di Paroki St. Kornelius Pohon Bao, Keuskupan Larantuka. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Lokasi penelitian di Paroki St. Kornelius Pohon Bao, Keuskupan Larantuka. Penelitian ini dilaksanakan pada bulan Ferbuari sampai dengan bulan Mei 2023. Subjek yang diambil dalam penelitian ini sebanyak 7 orang. Teknik pengumpulan data dalam penelitian ini yakni teknik wawancara, observasi, dan dokumentasi. Teknik analisa data dalam penelitian ini adalah reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian mengatakan bahwa Orang Muda Katolik di Paroki St. Kornelius Pohon Bao, Keuskupan Larantuka sudah memahami secara baik tentang koinonia dan moderasi beragama. Pemahaman yang baik ini diwujudkan dalam sikap membangun kebersamaan, persaudaraan, solidaritas, kerjasama, partisipasi dalam kegiatan bersama dan memberikan kontribusi dalam upaya membangun moderasi beragama. Kesadaran ini membuat mereka melibatkan diri atau dilibatkan dalam berbagai kegiatan keagamaan dan kegiatan sosial kemasyarakatan lainnya.