bluuebunny/crossref_metadata_2025_split huggingface dataset:
Piloting “From the Inside Out” - a toolkit addressing tuberculosis-related self-stigma: A feasibility study
Authors: Macdonald Stephen H-F , France Nadine Ferris , Hodgson Ian , Ali Fadhil , Dewi Christa , Abdurrakhman Iman , Runtu Yeremia Mozart , Juan Alva , Sugiharto Jhon , Byrne Elaine , Conroy Ronan 
Published: July 2023

Abstract
Self-stigma among people who have tuberculosis (TB) can contribute to non-adherence to medication and disengagement from care. It can manifest in feelings of worthlessness, shame, and guilt, leading to social withdrawal and disengagement from life opportunities. Self-stigma may also affect families of those who have TB, or healthcare workers who treat them. However, few interventions addressing TB self-stigma exist to-date. We therefore piloted the delivery of a toolkit of psychosocial interventions using a “train the trainers” approach with six staff members of a TB-focused NGO and partner organisations in Jakarta, Indonesia. These trainers could then disseminate the toolkit among community partner organisations. Local staff involvement throughout the study supported translation and adaptation to enhance cultural and language appropriateness. Over a two-day training-of-trainers workshop, the NGO staff were familiarised with the mode of delivery of the toolkit, which they then delivered via a four-day participatory workshop with 22 representatives of partner organisations working among communities affected by TB. The newly-trained NGO staff delivered the toolkit to the participants, who self-reported significant increases in knowledge and efficacy around TB self-stigma post-intervention compared to baseline (Z = 1.991, p = 0.047). The participants' levels of self-compassion were also significantly higher post-workshop (Z = 2.096, p = 0.036), however, this effect was not maintained at three-month timepoint. There was also a significant increase post-workshop in the participants' Ryff dimensions of psychological wellbeing in the dimension of positive relationships with others (Z = 2.509, p = 0.012) and self-acceptance was significantly higher at 3-month follow-up (Z = 2.877, p = 0.004). Environmental mastery was significantly lower at 3-month follow-up (Z = 2.670, p = 0.008). Observed changes in recipients’ self-reported levels of knowledge and efficacy, self-compassion, and psychological wellbeing may warrant further investigation into the best modalities for toolkit delivery (frequency, dose, duration) and support for individuals as they progress through the TB treatment journey.
Nonlocal response of planar plasmonic layers
Authors: Burda Milan , Richter Ivan , Kwiecien Pavel 
Published: July 2023

Abstract
Nonlocal interactions of plasmonic nanostructures are currently beingintensively investigated. It is generally accepted that nonlocal interactionsare most pronounced on structures with nanometer unit sizes andaffect the shape of spectral functions of characterizing quantities in theresonance region. Numerical analysis of nonlocal phenomena is very complicatedand it is advantageous to use it for the analysis of geometricallymore complex structures. For some simple structures it is possible to findanalytical solutions which can then be used, among other purposes, tobuild semi-analytical approaches for the analysis of some more complexstructures. This article is focused on the efficient description of nonlocalmanifestations of a planar metal layer using a hydrodynamic model. Thismodel is further extended to the more general case of two adjacent nonlocallayers (bilayers). The results for both single layer and bilayer case arepresented and discussed in detail. Also, one of the here presented importanttechnical results are the transfer matrices for the nonzero normalcomponent of the current densities at the interfaces of the metal layer.
Efficacy and safety of pyrotinib for patients with HER2-positive advanced breast cancer : a retrospective multicenter real-world study
Authors: Li Yongxia , Li Yong , Li Taolang , He Mingyuan , Chang Jianying , Cao Hui , Luo Daiqin , Lv Junyuan , Zou Yunbi , Zheng Yuyan , Wang Hongxia , Ran Li , Yang Feiyue , Huang Li , Chen Xiaoming 
Published: July 2023

Abstract
Purpose
The incidence of breast cancer ranks first among female malignancies that affect women's health. Human epidermal growth factor 2 (HER2) positive breast cancer accounts for 20% − 30% of the invasive breast cancer, which is related to the poor prognosis of the tumor. This study aimed to observe the efficacy and safety of pyrotinib in HER2-positive advanced breast cancer in the real world.
Methods
This multicenter retrospective study was performed on the clinical data of HER2-positive advanced breast cancer patients treated with pyrotinib from March 2019 to April 2022. Progression-free survival (PFS), overall survival (OS), objective response rate (ORR), disease control rate (DCR), clinical benefit rate (CBR) and occurrence of adverse events were observed after treatment, and possible predictors of efficacy were explored.
Results
A total of 91 female patients enrolled, with a median age of 51 years (range, 30–76), a median PFS of 14.3 months (95%CI: 8.8–19.8), and a median OS of 30.0 months (95%CI: 23.8–36.2). Short-term efficacy showed that 4 cases of complete remission (CR), 61 cases of partial remission (PR), 23 cases of stable disease (SD) and 3 cases of progression disease (PD) were identified, and the ORR, DCR and CBR were 71.4%, 96.7% and 74.7%, respectively. The main treatment-related adverse event was diarrhea. Log-rank analysis showed a significant difference in OS between patients with liver metastases and patients with non-liver metastases (15.8 months vs 31.4 months, HR = 2.30, P < 0.05). The results of the Cox regression model indicated that the number of pyrotinib treatment lines was an independent risk factor affecting PFS and OS of patients (HRPFS =1.81, HROS =1.91, P < 0.05).
Conclusions
Pyrotinib-based regimens were safe and effective in the treatment of HER2-positive advanced breast cancer, and the earlier use was better. Pyrotinib-based therapy might have some advantages in patients without liver metastases. This study set the stage for further exploration of the treatment paradigm of pyrotinib.
Quantitative Shaking Evaluation of Bracing-Strengthened and Base Isolated Building using Seismic Intensity Level (SIL)
Authors: Egatama H F , Wariyatno N G , Han A L , Gan B S 
Published: July 2023

Abstract
This paper presents a new and comprehensive design philosophy for evaluating earthquake-induced shaking and vibrations based on Japan Meteorological Agency (JMA) formulas. The goal of determining Seismic Intensity Level (SIL) is to identify measures or actions that can minimize the risk of human casualties during earthquakes. This study aims to assess the application of SIL as an evaluation tool for the seismic aspect of a building. Three categories of building model, which are existing building (a 15x12x18.1 m frame building without strengthening), bracing-strengthened buildings, and Base Isolated buildings, were evaluated. The evaluation criteria are the maximum acceleration of the roof, energy dissipation, and measured Seismic Intensity Level (m-SIL) according to JMA calculation. Models were subjected to the 1940 El Centro seismic wave of the North-South (N-S) orientation as the ground motion. From this study, the evaluation using Seismic Intensity Level (SIL) provides more consistency and is simpler to comprehend. The application of SIL as an evaluation tool for comparing the performance of the two strengthening methods proves that the base isolation (BI) method performs safer shaking of the building than bracing strengthening. An indicative chart is also proposed to help designers generatecost estimation of SIL.
Enhancement in selectivity of trivalent Am over Cm by modulating donor centres of aza- macrocyclic ligands: An implication of their differences in bonding
Authors: Chattaraj Saparya , Bhattacharyya Arunasis 
Published: July 2023

Abstract
Efficient management of the high-level liquid waste (HLW) generated during the reprocessing of nuclear fuel involves mutual separation and transmutation of the minor actinides like Am and Cm, which are chemically very similar. In the present work, an in-silico analysis of the bonding of Am(III) and Cm(III) ions with donor center modulated azacrown based ligand, i.e., a ligand formed by replacing the four ‘O’s of the azacrown macrocycle in N,N’-bis[(6-carboxy-2-pyridyl)-methyl]-1,10-diaza-18-crown-6 (L1) with four ‘S’s (L2) is carried out using relativistic density functional theory to develop a deeper understanding of the impact of both, soft donors as well as the cavity effects on the separation of these metal ions. The subtle differences in the bonding is brought about by the covalent interaction of the metal and the aza-macrocyclic O and S donors. The electron donation from the ligand is mostly accepted in the metal 6d orbitals and minimally to the 5f orbitals. But the f-orbital participation plays the crucial role in bringing about the subtle difference in the bonding between Am(III) and Cm(III) ions with the ligands. The trivalent Cm ion with half-filled initial f7 configuration shows resistance in participating in bonding as was observed from NPA, QTAIM, NBO and DOS analyses. Whereas, the Am(III) ions having f6 configuration are eager to accept f-electrons to achieve the stable half-filled configuration. The energetics elucidated that both L1 and L2 ligands are Am selective. But the extraction capacity and selectivity is higher for the L2 ligand. The Am selectivity can be attributed to the significant covalent interaction of S donors which have better electron donating capacity (than O) to the electron deficient Am(III) ion. This study is anticipated to throw some light on the implication of the bonding features on their separation.
The Utility of Routine MRI Surveillance Screening in Pediatric CNS Tumor Survivors
Authors: Cacciotti Chantel , Lenzen Alicia , Self Chelsea , Pillay-Smiley Natasha 
Published: July 2023

Abstract
Purpose
Surveillance magnetic resonance imaging (MRI) is routinely used to detect recurrence in pediatric central nervous system (CNS) tumors. Frequency of neuroimaging surveillance varies with no standardized approach.
Methods
We sought via a single institution retrospective cohort study to evaluate the frequency of recurrence identified by surveillance neuroimaging versus those detected clinically.
Results
This study included 476 patients; the majority diagnosed with a low-grade glioma (LGG) (n = 138; 29%), high grade glioma (HGG) (n = 77; 16%), ependymoma (n = 70; 15%) or medulloblastoma (n = 61; 13%). Patients with LGG, HGG and ependymoma more commonly had multiply recurrent disease (p = 0.08), with those with ependymoma demonstrating two or more relapses in 49% of cases. Recurrent disease was identified by imaging more often than clinical symptoms (65% vs 32%; p = < 0.01). Mean time to first relapse and subsequent relapse for the entire cohort was 30 months (range 1 day − 24.8 years) and 19.5 months (range 1 week-19.6 years), respectively. Patients diagnosed with meningioma demonstrated the longest mean time to first relapse (74.7 months), whereas those with Atypical Teratoid Rhabdoid Tumor (ATRT) and Choroid plexus papilloma tended to have the shortest time to relapse (8.9 months and 5.5 months, respectively). Overall, 22 patients sustained the first relapse > 10 years from initial diagnosis (9 LGG, 4 medulloblastoma, 3 meningioma, 2 germ cell tumor, 1 pineoblastoma, 1 craniopharyngioma, and 2 other).
Conclusion
With a higher tendency towards detection of tumor recurrence/progression on MRI surveillance in comparison to clinical progression, surveillance imaging should be considered in routine follow up of pediatric CNS tumor survivors. With some relapses > 10 years from initial diagnosis, imaging beyond this time point may be useful in particular tumor types.
Risk of COVID-19 death in adults who received booster COVID-19 vaccinations: national retrospective cohort study on 14.6 million people in England
Authors: Ward Isobel 
Published: July 2023

Abstract
Importance: The emergence of the COVID-19 vaccination has been critical in changing the course of the COVID-19 pandemic, with estimates suggesting vaccinations have prevented millions of deaths worldwide. To ensure protection remains high in vulnerable groups booster vaccinations in the UK have been targeted based on age and clinical vulnerabilities.
Objective: We sought to identify adults who had received a booster vaccination as part of the autumn 2022 campaign in England yet remained at increased risk of postbooster COVID-19 death and compared to non-COVID-19 risk.
Design, Setting, and Participants: We undertook a national retrospective cohort study using data from the 2021 Census linked to electronic health records. We fitted cause-specific Cox models to examine the association between health conditions and the risk of COVID-19 death and all-other-cause death for adults aged 50-100-years in England vaccinated with a booster in autumn 2022. Our total population was 14,644,570 people; there were 6,800 COVID-19 deaths and 150,075 non-COVID-19 deaths.
Exposure: Sociodemographic characteristics (sex, age, ethnic group, region), disability, body mass index, and diagnosis of a health condition defined from QCovid2.
Main Outcomes and Measures: The primary outcome of this study was COVID-19 death. The secondary outcome was all-cause non-COVID-19 deaths.
Results: Having learning disabilities or Down Syndrome (hazard ratio=5.07;95% confidence interval=3.69-6.98), pulmonary hypertension or fibrosis (2.88;2.43-3.40), motor neuron disease, multiple sclerosis, myasthenia or Huntington’s disease (2.94, 1.82-4.74), cancer of blood and bone marrow (3.11;2.72-3.56), Parkinson’s disease (2.74;2.34-3.20), lung or oral cancer (2.57;2.04 to 3.24), dementia (2.64;2.46 to 2.83) or liver cirrhosis (2.65;1.95 to 3.59) was associated with an increased risk of COVID-19 death. Individuals with cancer of the blood or bone marrow, chronic kidney disease, cystic fibrosis, pulmonary hypotension or fibrosis, or rheumatoid arthritis or systemic lupus erythematosus had a significantly higher risk of COVID-19 death relative to other causes of death compared with individuals who did not have diagnoses.
Conclusions, and Relevance: We identify groups who are at increased risk of postbooster COVID-19 death relative to non-COVID-19 deaths. Policy makers should continue to priorities vulnerable groups for subsequent COVID-19 booster doses to minimise the risk of COVID-19 death.
General infectious and neurological manifestations of new coronavirus infection COVID-19
Authors: Ignatieva O. I. , Pavelkina V. F. , Ignatiev V. N. , Erovichenkov A. A. 
Published: July 2023

Introduction. The most important problems of clinical characterization and timely diagnosis of a new coronavirus infection COVID- 19 have been identified. The detection and treatment of patients with COVID-1 9 in the domestic health care system are carried out according to the Provisional Methodical Recommendations “Prevention, Diagnostics and Treatment of New Coronavirus Infection”. Its basic clinical manifestations are characterized by typical symptoms of acute respiratory viral disease: fever, dry cough, stuffy nose, headache, etc.Objective. To study the nature of clinical manifestations of new coronavirus infection COVID-1 9, associated with delta strain of SARS-CoV-2 coronavirus with moderate and severe course.Materials and methods. We analyzed the course of the disease in 50 patients treated as inpatients at Saransk Covid Hospital. Questionnaires to analyze complaints and anamnesis of diseases, data of medical records of in-patients were used. We used visual analog scale (VAS) to estimate the intensity of non-specific neurological disturbances, decreased sense of smell, taste and hearing, where 0 point means no neurological disturbance, 10 points – expressed disturbance. The presented data allowed to analyze the general, nonspecific and specific neurological manifestations of the new coronavirus infection COVID- 19 in the acute period in patients with moderate and severe course and to reveal their peculiarities.Results. At a moderately severe course of the disease, the characteristic symptoms of respiratory infection in combination with depressed mood and anxiety predominated. Of nonspecific neurological disorders, sleep disturbances, dizziness, and of specific manifestations, impaired sense of smell and taste prevailed. At a severe course the above symptoms were joined by myalgia, headache, dyspnea and shortness of breath, gastrointestinal disorders.Conclusions. The severity of the course of COVID-1 9 coronavirus infection, associated with the delta strain of SARS-CoV-2 coronavirus, is determined by the severity of the generalized manifestations, involvement of the lower respiratory tract, gastrointestinal disorders.
Experience of effective correction of the main manifestations of postcovid syndrome
Authors: Shishkova V. N. , Shishkov V. A. , Ustarbekova D. B. , Mashkovtseva E. V. , Nartsissov Ya R. 
Published: July 2023

Introduction. Postcovid syndrome is an urgent problem, due to its high frequency regardless of the severity of the infection and the age of the patient.Aim. To evaluate the efficacy and safety of the use of a dietary supplement Metabovit® Healthy Sleep with Glycine and Zinc in patients with postcovid syndrome.Materials and methods. 50 patients with postcovid syndrome were included in the study, after randomization, Metabovit® Healthy Sleep was added to therapy in group 1 (2 tablets 3 times a day), in group 2 patients received basic therapy for chronic diseases. The duration of observation was 21 days. Before and after the end of the study all patients underwent clinical and neuropsychological examination, which included: complaint analysis, the “Schulte tables” test, a verbal association test, a Trail Making Test, an MFI-20 self-questionnaire, a Reader test, a questionnaire on the level of life exhaustion, a hospital scale of anxiety and depression (HADS).Results. In the group of patients receiving Metabovit® Healthy Sleep 2 tablets 3 times a day, in comparison with the control group, the overall MFI-20 self-questionnaire score sugnificantly (p < 0.001) decreased by 16 [-19, -8] to 59 [52; 63] points performance time of "Schulte tables" test decreased by more than 13 seconds; performance time of the Trail Making Test was 26 seconds faster in part A and 40 seconds faster in part B, in the verbal association test, the results reached normative values for most participants; stress levels decreased by almost 25% in men and 11% in women; the indicator of life exhaustion decreased by 22%; the level of anxiety (HADS score) decreased by 5 [-7; -3] points which led to the normalization of this indicator in almost all participants of the group. By the end of the study, no significant changes in the studied parameters were detected in patients of the control group.Conclusion. In the group of patients who received the Metabovit® Healthy Sleep dietary supplement, there was a significant positive dynamics and regression of most of the symptoms of postcovid syndrome, in comparison with the control group.
Pasajes del proceso científico develados
Authors: Hernández Coló María del Rosario , Romero Ruiz Rubén 
Published: July 2023

Resumen
Esta reseña presenta los contenidos del libro Delimitación del problema y la pregunta de investigación y resalta aquellos que le dan su propio carácter. Por ejemplo, se señala que las explicaciones teóricas que se proporcionan sobre los temas principales siempre vienen acompañadas de explicaciones didácticas, recomendaciones prácticas y un gran número de ejemplos referentes a distintas disciplinas. Estos elementos se expresan con un lenguaje directo y sencillo que facilita la comprensión de las ideas expuestas. En conjunto, el esfuerzo de las autoras por integrar una obra de esta naturaleza dio como resultado un material de estudio actualizado que motiva a investigar.
Formación docente en contextos de educación intercultural de México y Brasil
Authors: Silva Banda Rosario Berenice 
Published: July 2023

El presente artículo muestra los avances de una investigación, cuyo objetivo fue analizar y contrastar la formación docente que se desarrolla en dos contextos de educación intercultural: el primero en México, en la Escuela Normal Bilingüe e Intercultural de Oaxaca (ENBIO); el segundo en Brasil, en el Núcleo Takinahaky de Formación Superior Indígena de la Universidad Federal de Goiás (NTFSI - UFG). Se realizó un estudio con enfoque cualitativo, mediante el método de la etnografía virtual, para dar seguimiento online a la cultura escolar que prevalece en ambas instituciones y a las prácticas de formación docente que se fomentan. Con ese fin, algunas técnicas tradicionales de la investigación etnográfica, como la observación participante y la entrevista, se adaptaron e implementaron a la modalidad virtual; además, se recurrió a distintos materiales consultados y obtenidos de Internet. Los primeros resultados revelan que en ambas instituciones se forma para la docencia pluriétnica y plurilingüe de los pueblos originarios de la entidad oaxaqueña, así como de los pueblos nativos del centro, noreste y sureste de la nación brasileña, respectivamente, con una notable labor en el compromiso social para preservar la identidad cultural y lingüística de los pueblos originarios.
Development Of Teaching Materials Using A Scientific And Contextual Approach To Improve Mathematic Connection Ability
Authors: Malinda Pamila , Rohaeti Euis Eti , Sugandi Asep Ikin 
Published: July 2023

For students learning mathematics, mastery of concepts is important, one of which relates one concept to another. One of the abilities that students must have is the ability to connect mathematically, but it turns out that the facts in the field are still relatively low. In order to improve the learning process, a combination of scientific and contextual approaches can be used by developing teaching materials. This study aims to develop teaching materials using a combination of scientific and contextual approaches to improve the mathematical connection skills of junior high school students, the method used is Research and Development (R&D) ADDIE model. The results obtained from the limited and wider trial validity are valid and feasible to be used at the product testing stage, at the limited trial stage the practicality of lesson plans and worksheets by teachers is in the practical category and at the wider trial stage it is in the very practical category, the practicality ofÂ Student WorksheetsÂ by students at the limited trial stage and more broadly is in the practical category, The effectiveness was in the quite effective category in the limited trial stage, and it was in the effective category in the wider trial stage, then the implementation in the limited trial stage obtained a percentage of 81.2% and in the wider trial stage a percentage of 89.7% was obtained and for increasing mathematical connection ability, the N-Gain was 0.58 which was included in the medium category.