bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversible Iron Oxyfluoride (FeOF)‐Graphene Composites as Sustainable Cathodes for High Energy Density Lithium Batteries
Authors: Liu Yadong , Yu Yikang , Yang Fan , Zhu Guangqi , Yu Kang , Kou Ronghui , Sun Chengjun , Liu Yuzi , Xu Jiayi , Liu Cong , Li Chenzhao , Liu Tianwei , Ren Yang , Lu Wenquan , Ferreira Rafael , Ferreira Paulo , Zhang Zhengcheng , Xie Jian 
Published: January 2023

AbstractTwo large barriers are impeding the wide implementation of electric vehicles, namely driving‐range and cost, primarily due to the low specific energy and high cost of mono‐valence cathodes used in lithium‐ion batteries. Iron is the ideal element for cathode materials considering its abundance, low cost and toxicity. However, the poor reversibility of (de)lithiation and low electronic conductivity prevent iron‐based high specific energy multi‐valence conversion cathodes from practical applications. In this work, a sustainable FeOF nanocomposite is developed with extraordinary performance. The specific capacity and energy reach 621 mAh g−1 and 1124 Wh kg−1 with more than 100 cycles, which triples the specific capacity, and doubles the specific energy of current mono‐valence intercalation LiCoO2. This is the result of an effective approach, combing the nanostructured FeOF with graphene, realized by making the (de)lithiation reversible by immobilizing FeOF nanoparticles and the discharge products over the graphene surface and providing the interparticle electric conduction. Importantly, it demonstrates that introducing small amount of graphene can create new materials with desired properties, opening a new avenue for altering the (de)lithiation process. Such extraordinary performance represents a significant breakthrough in developing sustainable conversion materials, eventually overcoming the driving range and cost barriers.
Improving consistency of AADL models: A composition approach
Authors: Hamdane Mohamed Elkamel , Harous Saad , Kerkouche Elhillali , Nabil Messaoudi 
Published: January 2023

AbstractAADL—architecture analysis and design language—has proven to be important in developing real‐time embedded systems. However, its formalization capability is still limited, which makes it difficult to produce a consistent model; particularly, in the case where several models are combined together. Therefore, using formal verification is an effective way to meet the consistency requirements of the AADL model. This paper proposes a model‐based engineering approach that uses timed automata (TA) formalism to aggregate multiple AADL models into a single composite model. Based on the set of input AADL models, the proposed approach creates a consistent composed model as well as support model checking verification. The effectiveness of this contribution is evaluated through two case studies; a multicamera surveillance system and a drone system.
Enzymatic Reactions using Ionic Liquids for Green Sustainable Chemical Process; Stabilization and Activation of Lipases
Authors: Itoh Toshiyuki 
Published: January 2023

AbstractThe enzymatic reaction is highly respected from an environmentally‐friendly point‐of‐view. Optimization of the reaction media and supporting materials of enzymes must be investigated in parallel with the effort to develop new enzymes. Lipases are frequently used for organic syntheses as synthetic tools even industry because of their acceptance of having a broad range of substrates, stability, and availability. We have investigated the possibility of ILs as both a solvent and activating or stabilization agent of enzymes, in particular, lipase as a model enzyme. ILs allowed recyclable use of a lipase and significant acceleration of transesterification, and also enhanced the stability and reaction activity of a lipase by immobilization through a lyophilization process. We discuss how we enhanced the enzyme capability using the IL engineering focusing on lipase‐catalyzed reactions, i. e., realization of the recyclable use of an enzyme, how ILs mediated the enhanced reaction rate, and improved the stability of the enzyme.
Advanced nutrient removal and external sludge reduction: Demonstration in a pilot‐scale sequencing batch reactor
Authors: Yang Shenhua , Chang Haibin , Peng Yongzhen , Zhang Shujun , Han Xiaoyu , Sun Shihao , Liu Jinjin , Zhang Liang 
Published: January 2023

AbstractAlthough the addition of excess sludge fermentation products to improve nutrient removal from sewage is cost‐effective, its application has rarely been demonstrated. In this study, the external sludge was first collected and fermented under a sludge retention time of 10 days, then introduced into SBR with a 1:15 sewage ratio. The results revealed a gradual increase in the nitrite accumulation ratio to 34.7% in the SBR at the end of the oxic stage after 64 days of adding fermented sludge products. In addition, the average effluent total nitrogen and phosphorous decreased to 7.3 and 0.5 mg/L, corresponding to removal efficiencies of 86.7% and 95.5%, respectively. On the other hand, the use of the fermented sludge products as external organic carbon sources in the SBR increased the external sludge reduction ratio to 42.5%. High‐throughput sequencing demonstrated that the increase in the endogenous denitrifier community, polyphosphate‐accumulating organisms, and fermentation bacteria were the main factors contributing to the increase in nutrient removal and excess sludge reduction. The economic evaluation indicated that the operational cost of the pilot‐scale system saves 0.011$/m3 of sewage treated.Practitioner Points
Fermented sludge addition effectively enhanced nutrient removal in pilot‐scale SBR.
Average effluent TN and PO43−–P decreased to 7.3 and 0.5 mg/L, respectively.
Highest external sludge reduction rate was 42.5% in pilot‐scale reactor.
Sewage treatment cost can save 0.011$/m3 under advanced nutrient removal.
The role of STING signaling in central nervous system infection and neuroinflammatory disease
Authors: Fritsch Lauren E. , Kelly Colin , Pickrell Alicia M. 
Published: January 2023

AbstractThe cyclic guanosine monophosphate–adenosine monophosphate (GMP‐AMP) synthase‐Stimulator of Interferon Genes (cGAS‐STING) pathway is a critical innate immune mechanism for detecting the presence of double‐stranded DNA (dsDNA) and prompting a robust immune response. Canonical cGAS‐STING activation occurs when cGAS, a predominantly cytosolic pattern recognition receptor, binds microbial DNA to promote STING activation. Upon STING activation, transcription factors enter the nucleus to cause the production of Type I interferons, inflammatory cytokines whose primary function is to prime the host for viral infection by producing a number of antiviral interferon‐stimulated genes. While the pathway was originally described in viral infection, more recent studies have implicated cGAS‐STING signaling in a number of different contexts, including autoimmune disease, cancer, injury, and neuroinflammatory disease. This review focuses on how our understanding of the cGAS‐STING pathway has evolved over time with an emphasis on the role of STING‐mediated neuroinflammation and infection in the nervous system. We discuss recent findings on how STING signaling contributes to the pathology of pain, traumatic brain injury, and stroke, as well as how mitochondrial DNA may promote STING activation in common neurodegenerative diseases. We conclude by commenting on the current knowledge gaps that should be filled before STING can be an effective therapeutic target in neuroinflammatory disease.This article is categorized under:
Neurological Diseases > Molecular and Cellular Physiology
Infectious Diseases > Molecular and Cellular Physiology
Immune System Diseases > Molecular and Cellular Physiology
QCD resummation for groomed jet observables at NNLL+NLO
Authors: Dasgupta Mrinal , El-Menoufi Basem Kamal , Helliwell Jack 
Published: January 2023

Abstract
We use a direct QCD approach to carry out the next-to-next-to-leading logarithmic (NNLL) resummation for observables groomed with the modified mass-drop tagger (Soft Drop β = 0). We focus on observables which are additive given an arbitrary number of soft-collinear emissions. For this class of observables, we arrange the structure of the NNLL terms into two distinct categories. The first defines a simplified inclusive tagger, whereby the NNLL collinear structure is directly related to ungroomed observables. The second defines a clustering correction which takes a particularly simple form when the Cambridge-Aachen (C/A) algorithm is used to cluster the jets. We provide, in addition to the QCD resummation of groomed jet mass, the first NNLL resummed predictions, matched to NLO, for a range of groomed jet angularities with mMDT grooming. Moreover, we also include for the first time in the same calculation, finite zcut effects computed at NLL level alongside the small zcut NNLL results which simultaneously improves upon both of the calculations used for groomed jet mass phenomenological studies to date. While for simplicity we focus on e+e− collisions, the essential NNLL resummation we develop is process independent and hence with the appropriate NLO matching our results are also applicable for hadron collider phenomenology.
A Selberg zeta function for warped AdS3 black holes
Authors: Martin Victoria L. , Poddar Rahul , Þórarinsdóttir Agla 
Published: January 2023

Abstract
The Selberg zeta function and trace formula are powerful tools used to calculate kinetic operator spectra and quasinormal modes on hyperbolic quotient spacetimes. In this article, we extend this formalism to non-hyperbolic quotients by constructing a Selberg zeta function for warped AdS3 black holes. We also consider the so-called self-dual solutions, which are of interest in connection to near-horizon extremal Kerr. We establish a map between the zeta function zeroes and the quasinormal modes on warped AdS3 black hole backgrounds. In the process, we use a method involving conformal coordinates and the symmetry structure of the scalar Laplacian to construct a warped version of the hyperbolic half-space metric, which to our knowledge is new and may have interesting applications of its own, which we describe. We end by discussing several future directions for this work, such as computing 1-loop determinants (which govern quantum corrections) on the quotient spacetimes we consider, as well as adapting the formalism presented here to more generic orbifolds.
TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance
Authors: Zhao Juanjuan , Jia Li , Tao YiJing , Zhao Xu , Yang Jing , Lu Yanxin , Yan Yaping , Mao Ling , Hu Lin , Lu Jia , Guo MengMeng , Chen Chao , Zhou Ya , Wen Zhenke , He Zhixu , Xu Lin 
Published: January 2023

Abstract
Background
Endotoxin tolerance (ET) is a protective mechanism in the process of sepsis, septic shock, and their sequelae including uncontrolled inflammation. Accumulating evidence has shown that peripheral T cells contribute to the induction of ET. However, what and how T-cell development contributes to ET inductions remain unclear.

Methods
Mice were intraperitoneally injected with LPS at a concentration of 5 mg/kg to establish an LPS tolerance model and were divided into two groups: a group examined 72 h after LPS injection (72-h group) and a group examined 8 days after LPS injection (8-day group). Injection of PBS was used as a control. We performed high-throughput sequencing to analyze the characteristics and changes of CD4+SP TCRβ CDR3 repertoires with respect to V direct to J rearrangement during the ET induction. Moreover, the proportion and proliferation, as well as surface molecules such as CD80 and CD86, of F4/80+ macrophages were analyzed using FCM. Furthermore, ACT assay was designed and administered by the tail vein into murine LPS-induced mouse model to evaluate the role of F4/80+ macrophages on the development of CD4+SP thymocytes in ET condition.

Results
We found that the frequency and characteristics of the TCRβ chain CDR3 changed obviously under condition of ET, indicating the occurrence of TCR rearrangement and thymocyte diversification. Moreover, the absolute numbers of F4/80+ macrophages, but not other APCs, were increased in thymic medulla at 72-h group, accompanied by the elevated function-related molecules of F4/80+ macrophages. Furthermore, adoptively transferred OVA332-339 peptide-loaded macrophages into Rag-1−/− mice induced the clone deletion of OVA-specific CD4+SP, thereby ameliorating the pathology in lung tissue in LPS challenge.

Conclusions
These data reveal that the frequency and characteristics of the TCRβ chain CDR3 undergo dynamic programming under conditions of LPS tolerance. Furthermore, the peripheral macrophages may be a key factor which carry peripheral antigen to thymic medulla and affect the negative selection of T-cell population, thereby contributing to the formation of ET. These results suggest that the clone selection in thymus in ET may confer protection against microbial sepsis.
Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer
Authors: Zou Hailin , Luo Juan , Guo Yibo , Tong Tongyu , Liu Yuchen , Chen Yun , Xiao Yunjun , Ye Liping , Zhu Chengming , Deng Liang , Wang Bo , Pan Yihang , Li Peng 
Published: January 2023

AbstractSRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying regulatory mechanism are still elusive. Here, we identified a YAP1 tyrosine phosphorylation-dependent YAP1-KLF5 oncogenic module, as the key downstream mediator of SRC kinase regulating cancer stemness and metastasis in triple-negative breast cancer (TNBC). SRC was overexpressed in TNBC patient tissues and its expression level was highly correlated with the tumor malignancy. SRC activation induced, while inhibition of SRC kinase reduced the cancer stemness, tumor cell growth and metastasis in vitro and in vivo. Transcriptomic and proteomic analysis revealed that SRC-mediated YAP1 tyrosine phosphorylation induced its interaction with Kruppel-like factor 5 (KLF5) to form a YAP1/TEAD-KLF5 complex in TNBC cells. YAP1-KLF5 association further promoted TEAD-mediated transcriptional program independently of canonical Hippo kinases, which eventually gave rise to the enhanced cancer stemness and metastasis. Disruption of YAP1-KLF5 module in TNBC cells dramatically attenuated the SRC-induced cancer stemness and metastasis in vitro and in vivo. Accordingly, co-upregulations of SRC and YAP1-KLF5 module in TNBC tissues were significantly positively correlated with the tumor malignance. Altogether, our work presents a novel tyrosine phosphorylation-dependent YAP1-KLF5 oncogenic module governing SRC-induced cancer stemness and metastasis in TNBC. Therefore, targeting YAP1/KLF5-mediated transcription may provide a promising strategy for TNBC treatment with SRC aberrantly activation.
A nationwide analysis on the interaction between frailty and beta-blocker therapy in hip fracture patients
Authors: Forssten Maximilian Peter , Mohammad Ismail Ahmad , Ioannidis Ioannis , Wretenberg Per , Borg Tomas , Cao Yang , Ribeiro Marcelo A. F. , Mohseni Shahin 
Published: January 2023

Abstract
Introduction
Hip fracture patients, who are often frail, continue to be a challenge for healthcare systems with a high postoperative mortality rate. While beta-blocker therapy (BBt) has shown a strong association with reduced postoperative mortality, its effect in frail patients has yet to be determined. This study’s aim is to investigate how frailty, measured using the Orthopedic Hip Frailty Score (OFS), modifies the effect of preadmission beta-blocker therapy on mortality in hip fracture patients.

Methods
This retrospective register-based study included all adult patients in Sweden who suffered a traumatic hip fracture and subsequently underwent surgery between 2008 and 2017. Treatment effect was evaluated using the absolute risk reduction (ARR) in 30-day postoperative mortality when comparing patients with (BBt+) and without (BBt-) ongoing BBt. Inverse probability of treatment weighting (IPTW) was used to reduce potential confounding when examining the treatment effect. Patients were stratified based on their OFS (0, 1, 2, 3, 4 and 5) and the treatment effect was also assessed within each stratum.

Results
A total of 127,305 patients were included, of whom 39% had BBt. When IPTW was performed, there were no residual differences in observed baseline characteristics between the BBt+ and BBt- groups, across all strata. This analysis found that there was a stepwise increase in the ARRs for each additional point on the OFS. Non-frail BBt+ patients (OFS 0) exhibited an ARR of 2.2% [95% confidence interval (CI) 2.0–2.4%, p < 0.001], while the most frail BBt+ patients (OFS 5) had an ARR of 24% [95% CI 18–30%, p < 0.001], compared to BBt- patients within the same stratum.

Conclusion
Beta-blocker therapy is associated with a reduced risk of 30-day postoperative mortality in frail hip fracture patients, with a greater effect being observed with higher Orthopedic Hip Frailty Scores.
Particle tracking velocimetry as a method for chip ejection studies during groove milling of particleboard
Authors: Hausmann Julius , Hafemann Thomas E. , Rüdiger Frank , Herzberg Marcus , Gottlöber Christian 
Published: January 2023

AbstractStudies on chip ejection from tools provide important information for the design of tools and effective chip collection elements used in woodworking machines. Among the chip properties, chip motion and its distribution are of particular interest for the design process. Until now, chip velocities have only been measured by manual tracking over a high-speed image sequence, which allows only a small scope of inspection. Here, we present the use of high-speed imaging in combination with particle tracking velocimetry as a new method for the semi-automatic evaluation of the magnitudes and directions of chip velocities. The methodology was tested in groove milling of particleboard. It was found that state-of-the-art particle tracking algorithms are suitable for quantitative analysis of chip motion in high-speed images. Therefore, spatial and temporal analysis of the chip velocity along the tool circumference are feasible and are presented here. In addition to chip velocity, chip collisions with the tool or other chips can be observed. This research also shows that image evaluation of chip sizes and shapes is potentially possible. In summary, the presented work provides methods that can quantitatively describe chip motion after chip formation. The experiments indicate that with each tooth engagement, new chips are formed, which initially move into the chip space at a median velocity higher than the cutting speed. After collisions with the tool and interparticle collisions, the particles leave the chip space of the tool at lower speeds. The machining tests performed with different process settings showed differences in the analysis results of chip movement. In the future, the presented methodology offers the possibility of investigating the relationships between tooth and chip space geometries, as well as different materials and the chip ejection of tools. Thus, the presented methodology provides a basis for creating a more general understanding of chip motion from machining operations, which can lead to innovations and improvements in chip collection.
A house is not a home: a network model perspective on the dynamics between subjective quality of living conditions, social support, and mental health of refugees and asylum seekers
Authors: Schilz Laura , Kemna Solveig , Karnouk Carine , Böge Kerem , Lindheimer Nico , Walther Lena , Mohamad Sara , Suboh Amani , Hasan Alkomiet , Höhne Edgar , Banaschewski Tobias , Plener Paul , Strupf Michael , Hahn Erik , Bajbouj Malek 
Published: January 2023

Abstract
Background:
Providing adequate living conditions for forcibly displaced people represents a significant challenge for host countries such as Germany. This study explores refugee mental health’s reciprocal, dynamic relationship with post-migration living conditions and social support.

Methods:
The study sample included 325 Arabic- or Farsi-speaking asylum seekers and refugees residing in Germany since 2014 and seeking mental health treatment. Associations between reported symptoms of post-traumatic stress and depression and the subjective quality of living conditions and perceived social support were analyzed using a two-level approach including multiple linear regression and network analyses.

Results:
Post-migration quality of living conditions and perceived social support were significantly associated with negative mental health outcomes on both levels. In the network, both post-migration factors were negatively connected with overlapping symptoms of psychiatric disorders, representing potential target symptoms for psychological treatment.

Conclusion:
Post-migration quality of living conditions and social support are important factors for refugee mental health and should be targeted by various actors fostering mental well-being and integration.
Algorithmic counting of nonequivalent compact Huffman codes
Authors: Elsholtz Christian , Heuberger Clemens , Krenn Daniel 
Published: January 2023

AbstractIt is known that the following five counting problems lead to the same integer sequence $${f_t}({n})$$

f
t

(
n
)

:

the number of nonequivalent compact Huffman codes of length n over an alphabet of t letters,

the number of “nonequivalent” complete rooted t-ary trees (level-greedy trees) with n leaves,

the number of “proper” words (in the sense of Even and Lempel),

the number of bounded degree sequences (in the sense of Komlós, Moser, and Nemetz), and

the number of ways of writing $$\begin{aligned} 1= \frac{1}{t^{x_1}}+ \dots + \frac{1}{t^{x_n}} \end{aligned}$$

1
=

1

t

x
1

+
⋯
+

1

t

x
n

with integers $$0 \le x_1 \le x_2 \le \dots \le x_n$$

0
≤

x
1

≤

x
2

≤
⋯
≤

x
n

.

In this work, we show that one can compute this sequence for all$$n<N$$

n
<
N

with essentially one power series division. In total we need at most $$N^{1+\varepsilon }$$

N

1
+
ε

additions and multiplications of integers of cN bits (for a positive constant $$c<1$$

c
<
1

depending on t only) or $$N^{2+\varepsilon }$$

N

2
+
ε

bit operations, respectively, for any $$\varepsilon >0$$

ε
>
0

. This improves an earlier bound by Even and Lempel who needed $${O}({{N^3}})$$

O
(

N
3

)

operations in the integer ring or $$O({N^4})$$

O
(

N
4

)

bit operations, respectively.