bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Sojourn of Polymeric Micelles for Effective Brain Drug Delivery
System
Authors: Kaur Prabhjot , Rajput Ankita , Singh Dilpreet , Singh Gurdeep , Mehra Anshula , Kaur Sarabjit , Bedi Neena , Arora Saroj 
Published: April 2023

Abstract:
The brain is a delicate organ and targeting neurological diseases with conventional approaches
is still a daunting task. This is due to the presence of necessary physiological barriers, mainly the
blood-brain barrier, that blocks the entry of dangerous and poisonous substances from the bloodstream,
thus helping in maintaining homeostasis. Furthermore, the presence of multidrug resistance transporters
which act by prohibiting the entry of drugs across the cell membrane and by channelizing them to the
outside environment is another defense mechanism. Despite the advancements in the understanding of
disease pathology, only a restricted number of drugs and drug therapies can treat and target neurological
diseases. To overcome this shortcoming, the therapeutic approach using amphiphilic block copolymers -
using polymeric micelles has gained momentum because of its wide applications like drug targeting,
delivery, and imaging. Polymeric micelles are nanocarriers that arise when amphiphilic block copolymers
spontaneously assemble in aqueous solutions. The hydrophobic core–hydrophilic shell configuration
of these nanoparticles makes it easier to load hydrophobic drugs into the core and as a result, the
solubility of these medications is improved. Micelle-based drug delivery carriers can target the brain
with reticuloendothelial system uptake and produce a long-circulating effect. PMs can also be combined
with targeting ligands that increase their uptake by specific cells and thus decreasing off-target effects.
In the present review, we primarily focused on polymeric micelles for brain delivery along with the
method of preparation, mechanism of micelle formulation, and the ongoing formulations under clinical
trials for brain delivery.
Reaction Optimization of Strontium Perchlorate Catalyzed Novel Protocol
for Stereoselective Synthesis of Dihydropyrimidinones
Authors: Chauhan Divya , Chopra Harish Kumar , Nayak Surendra Kumar 
Published: April 2023

Background:
Hydrated strontium perchlorate [Sr(ClO4)2.3H2O] acts as a very strong oxidizing and dehydrating agent. Until now, it could not be reported as a catalyst in dehydration mechanism-based organic synthetic reactions. Therefore, it is important to find whether it could be an effective catalyst for one-pot multicomponent reactions (MCRs).

Objective:
The main objective of the present work is the development of a novel process for the synthesis of 1,4-dihydropyrimidinones through the one-pot multicomponent strategy using hydrat-ed Sr(ClO4)2 as a catalyst. Furthermore, it includes process optimization, stereoselectivity, and spectroscopic characterization of the synthesized compounds.

Methods:
Conventional and microwave-supported synthesis of 1,4-dihydropyrimidinones using 20 mol % of hydrated Sr(ClO4)2 catalyst via the one-pot solvent-free reaction was discovered as a new catalytic MCR methodology. The box-Behnken design approach and advanced analytical techniques were used for process optimization and reaction analysis.

Results:
The results confirmed that hydrated Sr(ClO4)2 works as an efficient catalyst for one-pot multicomponent organic synthesis under both conventional and microwave heating. It is an effec-tive catalyst for laboratory synthesis of 1,4-dihydropyrimidinones stereoselectively with moderate to excellent yield without any undesirable effect. Microwave heating provided the desired product within 1-4 minutes. Moreover, this method provides easy isolation of the pure products simply by recrystallization, and without the use of a chromatographic purification method.

Conclusion:
The simplicity and neutrality of reaction conditions, easy post-reaction workup, higher satisfactory to excellent yield, effectiveness, the diversity of substrates, etc. render the hy-drated Sr(ClO4)2 catalyst-based protocol for the stereoselective synthesis of 1,4-dihydropyrimidinones as a highly efficient method. Furthermore, it has been found to be safe un-der laboratory reaction conditions and no undesirable issues have been faced during the process
Microsponges: A Neoteric Approach for the Effective Management of Osteoarthritis
Authors: Sen Shiwani , Sharma Anjali , Kriplani Priyanka , Guarve Kumar 
Published: April 2023

Background:A microsponge delivery system (MDS) is a cutting-edge and distinctive method of structured medication delivery. Regulated drug distribution is now possible with the use of microsponge technology. Techniques for drug release are created specifically to distribute medi-cations to the body's various locations. As a result, pharmacological therapy becomes more effec-tive, and patient compliance significantly affects the health care system.Main Body:MDS consists of porous microspheres with a substantially porous structure and a very small spherical shape, ranging in size from 5 to 300 microns. MDS is typically used to administer medications through topical channels, but new research has demonstrated the promise of this tech-nique for parenteral, oral, and ocular drug delivery. Topical formulations are an attempt to manage diseases like osteoarthritis, rheumatoid arthritis, psoriasis, etc. While reducing the drug's side ef-fects, MDS can readily change the pharmaceutical release shape and enhance formulation stability. Reaching the highest peak plasma concentration in the blood is the main goal of microsponge medi-cation delivery. The ability of MDS to self-sterilize is by far the most notable quality.Conclusion:In countless studies, MDS is employed as an anti-allergic, anti-mutagenic, and non-irritant. This review covers the overview of microsponges along with their release mechanism. The article focuses on the marketed formulation of microsponges and patent data of the same. This re-view will be helpful for researchers working in MDS technology.
Diagnostic Performance of Deep Learning in Screened Mammogram:
Systematic Review
Authors: Omega Boro Lal , Nandi Gypsy 
Published: April 2023

Background:
The usage of artificial intelligence in medical image analysis has significantly surpassed that of earlier related technologies. This paper aimed to
investigate the diagnostic accuracy of Artificial Intelligence (AI) based-deep learning models for breast cancer detection.

Methods:
We used the PICO (Patient/Population/Problem, Intervention, Comparison, Outcome) scheme to formulate the research question and construct our
search terms. Studies were systematically examined from the available literature using the constructed search terms from PubMed, and
ScienceDirect according to the PRISMA guidelines. The quality of the included studies was assessed using the QUADAS-2 checklist. The
characteristics of each included study such as the study design, population, index test, and reference standard, were extracted. The sensitivity,
specificity, and AUC for each study were also reported.

Results:
In this systematic review, 14 studies were analyzed. Eight studies showed that AI was more accurate than radiologists in evaluating mammographic
images, while one comprehensive study found AI to be less precise. Studies that reported sensitivity and specificity without radiologist intervention
showed performance scores ranging from 16.0% to 89.71%. With radiologist intervention, sensitivity was between 62% to 86%. Only three studies
reported a specificity of 73.5% to 79%. The AUC of the studies was between 0.79 and 0.95. Thirteen studies were retrospective, and one was
prospective.

Conclusion:
There's inadequate evidence on the effectiveness of AI-based deep learning for breast cancer screening in clinical settings. More research is
needed, including studies evaluating accuracy, RCTs, and large-scale cohort studies. This systematic review found that AI-based deep learning
improves radiologists' accuracy, especially for novice radiologists. Younger, tech-savvy clinicians may be more accepting of AI. Although it can't
replace radiologists, the encouraging results suggest it will play a significant role in identifying breast cancer in the future.
Tit Structure-activity Relationship Study and Design of Novel 1, 8-
Naphthimide Derivatives as Potential DNA-targeting Chemotherapeutic
Agents for Osteosarcoma
Authors: Lian Zheng , Si Hongzong , Xia Huanling , Zhai Honglin 
Published: April 2023

Background:
1, 8-naphthimide is a novel tumor inhibitor targeting nuclear DNA, which makes it applicable to the design and development of anti-osteosarcoma drugs.

Objective:
The aim of this study is to establish a satisfactory model based on 1, 8-naphthimide derivatives that makes reliable prediction as DNA-targeted chemotherapy agents for osteosarcoma.

Methods:
All compounds are constructed using ChemDraw software and subsequently optimized using Sybyl software. COMSIA method is used to construct QSAR model with the optimized compound in Sybyl software package. A series of new 1, 8-naphthalimide derivatives are designed and their IC50 values are predicted using the QSAR model. Finally, the newly designed compounds are screened according to IC50 values, and molecular docking experiments are conducted on the top ten compounds of IC50.

Results:
The COMSIA model shows that q2 is 0.529 and the optimum number of components is 6. The model has a high r2 value of 0.993 and a low SEE of 0.033, with the F value and the r2 predicted to be 495.841 and 0.996 respectively. The statistical results and verification results of the model are satisfactory. In addition, analyzing the contour maps is conducive to finding the structural requirements.

Conclusion:
The results of this study can provide guidance for medical chemists and other related workers to develop targeted chemotherapy drugs for osteosarcoma
Nanotechnology-based Drug Delivery Systems for the Treatment of Cervical Cancer: A Comprehensive Review
Authors: Singhai Manu , Das Gupta Ghanshyam , Khurana Bharat , Arora Daisy , Ashique Sumel , Mishra Neeraj 
Published: April 2023

Background:
Cancer is a global public health issue; in the United States, it is the second
leading cause of death. Furthermore, cancer, which consists of distinct subtypes of cancer cells and
variable components, may cause a continuum of carcinogenesis. It can be categorized according to
the part where it begins in the body, such as breast cancer or cervix cancer. Cervical cancer attacks
cervix cells, most commonly in the transition area, when the endocervix's glandular cells transform
into the exocervix's squamous cells. Cervical cancer is treated in several methods depending on the
degree and size of the tumour and frequently entails surgery, radiotherapy, and chemotherapy.

Methods:
It is vital to have an effective drug delivery system that may increase the treatment effectiveness
to overcome the limits of traditional therapy and achieve higher cancer therapeutic efficacy
that is successful in treating cervical cancer.
Additionally, these therapies are safer than traditional therapy. Although many nanocarriers have
been created, only a few numbers have received clinical approval to deliver anticancer medications
to the targeted areas where their predicted activity is to be seen.

Conclusion:
Along with the patents released, various research reports illustrating the value of
nanocarriers are addressed in this review. Some recent publications, clinical evidence, and patent
records on nanocarrier architectures have been given, strengthening the understanding of tumor
management.
A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor
Effect on Liver Cancer Cells and Protect against Hepatic Injury
Authors: Ren Juan , Yan Jun , Raza Faisal , Zafar Hajra , Wan Haopeng , Chen Xue , Cui Qingrong , Li Haiyang , Wang Xiangqi 
Published: April 2023

Background:
As a pentacyclic triterpenoid, OA (oleanolic acid) has exhibited antiinflammatory,
immunomodulatory and antitumor effects. VEGFR-2 (vascular endothelial cells
receptor-2) tyrosine kinase activity could be inhibited by apatinib, a small-molecule antiangiogenic
agent.

Objective:
Thus, this study sought to investigate the mechanism underlying the synergistic antitumor
activity of combined OA and apatinib patent.

Methods:
Through CCK8 (Cell counting kit 8 assay), flow cytometric and western blotting techniques,
we conducted in vitro studies on apatinib and OA effects on cell proliferation and apoptosis
in H22 cell line. H22 tumor-burdened mice model was established in vivo, while the related
signaling pathways were studied via pathological examination, western blotting and qPCR (quantitative
polymerase chain reaction).

Results:
Growth of H22 cells in vitro and in vivo could be inhibited effectively by apatinib and
OA. Thus, OA repaired liver function and inhibited oxidative stress induced by apatinib.

Conclusion:
OA can treat apatinib induced liver injury in H22 Tumor-burdened mice by enhancing
the suppresssive effect of apatinib on the growth of tumor.
Study of the Reliability for the Leakage Mitigation Methods using FinFETs
Authors: Kajal  , Sharma Vijay Kumar 
Published: April 2023

Introduction:
In the very large-scale integration (VLSI) industry, scaling plays an
important role in providing compact size and high-speed digital circuits. The major drawbacks
faced by logic circuits are power dissipation and process, voltage, and temperature (PVT)
variations. In the VLSI industry, the prediction of variability tolerance capability is mandatory
to know the future performance of the circuits. The impact of PVT variation is large in
nanoscale logic circuits and it has the power to alter the output characteristics of any logic
circuit. The reasons that cause PVT variations are manufacturing defects, environmental
conditions, and mishandling issues.

Aims and Objective:
This paper aims to discuss the process variations and briefly describe the
previous work related to variability and various factors involved in PVT simulations. It also
provides the idea of Monte-Carlo simulation in the Cadence Virtuoso tool.

Methods:
In this paper, the impact of PVT variations on different fin-shaped field effect
transistor (FinFET) circuits was evaluated using the Cadence Virtuoso tool. Monte-Carlo
simulation was performed on various leakage reduction techniques for the domino logic with the
help of a multi-gate predictive technology model (PTM) FinFET at a 16nm technology node.

Results:
The footer-less domino logic (FLDL) circuit is designed and simulated using different
leakage reduction techniques for reliability analysis.

Conclusion:
Cascaded leakage control transistor (CLCT) approach shows 81.75%, 67.83%, and
51.25% less statistical mean value for power dissipation as compared to conventional, on-off
logic (ONOFIC), and alternative ONOFIC approaches in the case of FLDL OR2 logic circuit,
respectively.
Dakwah era disrupsi: Mengurai ambivalensi menuju dakwah partisipatoris
Authors: Dermawan Andy 
Published: April 2023

Setiap manusia muslim adalah “marketing” Tuhan. Menyampaikan nilai Islam di era disrupsi bukanlah perkara mudah, selain dibutuhkan kemampuan beradaptasi dengan perkembangan zaman yang sedang terjadi juga dibutuhkan kesatuan visi dan misi atau kata dan tindakan yang integratif agar maksud dan tujuan dakwah tersampaikan dengan baik. Nilai-nilai mulia itu mesti terintegrasi dengan nilai-nilai sosial di masyarakat agar mereka memahami bahwa nilai Islam “sejalan” dengan nilai kemanusiaan. Hadirnya agama merupakan solusi yang dinantikan oleh zaman di dalam membantu pemecahan masalah yang berarti. Penafsiran ulang narasi agama menjadi niscaya agar maksud yang terkandung dari misi agama tersampaikan. Masalah muncul manakala ada ambivalensi di antara keduanya. Narasi agama dan maksudnya seolah semacam “jauh panggang dari api”. Tulisan ini bertujuan untuk menemukan ambivalensi dakwah sehingga potret dakwah ke depan lebih partisipatoris. Melalui pendekatan hermeneutis-historis-fenomenologis, yakni mengurai problematika dakwah secara tektual-kontekstual berdasarkan dinamika yang terjadi, maka diharapkan terurainya ambivalensi itu dapat membantu diformulasikannya model dakwah partisipatoris yang humanistik. Adapun implikasi dari kajian ini adalah membangun tatanan suatu masyarakat di dalam memahami narasi agama yang kontekstual dan memiliki kesadaran beragama yang humanis. Every Muslim human being is God's "marketing". Conveying Islamic values in an era of disruption is a challenging matter, apart from requiring the ability to adapt to the current developments, it also requires a unified vision and mission, or integrative words and actions, so that the aims and objectives of da'wah are conveyed properly. These noble values must be integrated with social values in society so that people understand that Islamic values are "in line" with human values. The presence of religion is a solution that has been long awaited in helping to solve significant problems. Reinterpretation of religious narratives is necessary so that the intentions contained in the religious mission are conveyed. Problems arise when there is ambivalence between the two. Religious narratives and their intentions seem to fall short of their purpose. This paper aimed to find the ambivalence of da'wah so that the future portrait of da'wah is more participatory. Through a hermeneutical-historical-phenomenological approach, namely analyzing the problems of da'wah textually-contextually based on the existing dynamics, it is hoped that dissolving this ambivalence can help formulate a humanistic participatory da'wah model. The implications of this study are to build the order of a society by understanding contextual religious narratives and having a humanist religious awareness.
Career reorientation during the Covid-19 pandemic: Evidence from fresh graduates of Indonesian colleges
Authors: Sa’adah Nurus , Fitria Vita , Widiastuti Rr Siti Kurnia 
Published: April 2023

This research aims to examine the impact of the COVID-19 pandemic on the career reorientation of fresh graduates at Indonesian universities. This study is necessary to determine the changes in attitudes and perceptions of recent graduates as they seek employment, as measured by indicators of psychological quality, gender, and spiritual level. Three Focus Group Discussion meetings were held to achieve the best results, and questionnaires were distributed to 85 resource people. Furthermore, an interpretive analysis model was used to describe the differences in job attainment experienced by respondents before, during, and after the COVID-19 pandemic. According to the study's findings, several changes occurred in the career orientation of fresh graduates from various universities in Indonesia before, during, and after COVID-19. Before the COVID-19 pandemic, fresh graduates had a strong career orientation, as evidenced by their high absorption of job opportunities. Unlike the results of the COVID-19 pandemic, the impact of COVID-19 on new graduates' careers is significant, affecting mental and physical health as well as social interactions.Keywords: Career reorientation; Fresh Graduates; Higher Education; Human Resources; COVID-19
The analysis of Bokoharjo digital marketing communication media in promoting its potential
Authors: Saputro Eko Prasetyo Nugroho , Widiarti Pratiwi Wahyu , Hidayati Ulfah , Disyacitta Fikri 
Published: April 2023

Bokoharjo village is located at a strategic tourist destination including Boko Temple, Banyunibo Temple, Barong Temple, Ijo Temple, Breksi Hills, and Obelix Hills which requires to be developed. The development of Bokoharjo Village as a tourist village can be realized through digital marketing communication to introduce its potential products and attractions to the wider community so that the economic sector in Bokoharjo Village can grow. This research aims to: (1) identify the existing digital marketing communication media in Bokoharjo Village (2) analyze the need for digital marketing communication media in Bokoharjo Village, and (3) identify the potential and attractions of Bokoharjo village to be promoted. This research was conducted at Bokoharjo employing descriptive-qualitative methods. This initial research provided useful insight for the development of digital marketing communication media which comform to the needs and potential of Bokoharjo Village to advance Bokoharjo as a tourism village. The research results show that the digital marketing communication media in Bokoharjo include website, Instagram, Facebook, Twitter, WhatsApp which are not well managed. The media needed by Bokoharjo is an integrated media platform which contains the typical potential of Bokoharjo. The Bokoharjo potentials that can be promoted consist of Banyunibo Temple, Banyunibo Cliff, and Shibori Batik, Agricultural Commodity, and Orchid.Keywords: Media, Communication, Marketing, Digital, Bokoharjo.
Pengaruh Liputan Media, Sensitivitas Lingkungan, Environmental Management System, dan Kedekatan Konsumen terhadap Pengungkapan Lingkungan
Authors: Zakaria Dinda Karunia Putri , Hastuti Sri , Widiastuti Sri Wahyuni 
Published: April 2023

ABSTRACTThis study aims to investigate empirical proof of the effect of media coverage, environmental sensitivity, environmental management system, and customer closeness on the environmental disclosure of companies listed on the Indonesia Stock Exchange in 2018-2020. The population in this study is all environmental disclosure on the company’s sustainability report listed on the Indonesia Stock Exchange in 2018-2020. This study sampling method is purposive sampling, with 15 companies meeting the criteria as the sample with 45 firm-years. This study was tested using multiple linear regression. The results of this study show that environmental sensitivity and customer closeness effect on company’s environmental disclosure. In contrast, media coverage and environmental management system do not affect the company’s environmental disclosure.Keywords: Environmental Disclosure, Media Coverage, Environment Sensitivity, Environmental Management System, Customer ClosenessABSTRAKPenelitian ini bertujuan untuk menemukan bukti empiris mengenai pengaruh liputan media, sensitivitas lingkungan, Environmental Management System (EMS), dan kedekatan konsumen terhadap pengungkapan lingkungan perusahaan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2018-2020. Populasi penelitian ini adalah seluruh pengungkapan lingkungan yang dilakukan perusahaan dalam laporan keberlanjutan oleh perusahaan yang terdaftar di Bursa Efek Indonesia (BEI) dalam periode 2018-2020. Metode pengambilan sampel dipilih menggunakan metode purposive sampling sehingga perusahaan yang memenuhi kriteria sebagai sampel sebanyak 15 perusahaan dengan total observasi sebanyak 45 perusahaan-tahun. Penelitian ini diuji dengan regresi linier berganda. Hasil penelitian ini menunjukkan bahwa sensitivitas lingkungan dan kedekatan konsumen berpengaruh terhadap pengungkapan lingkungan perusahaan sedangkan liputan media dan Environment Management System (EMS) tidak berpengaruh terhadap pengungkapan lingkungan perusahaan.Kata Kunci: Pengungkapan Lingkungan, Liputan Media, Sensitivitas Lingkungan, Environmental Management System, Kedekatan Konsumen