bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct input of monitoring data into a mechanistic ecological model as a way to identify the phytoplankton growth-rate response to temperature variations
Authors: Medvinsky Alexander B. , Nurieva Nailya I. , Adamovich Boris V. , Radchikova Nataly P. , Rusakov Alexey V. 
Published: June 2023

AbstractWe present an approach (knowledge-and-data-driven, KDD, modeling) that allows us to get closer to understanding the processes that affect the dynamics of plankton communities. This approach, based on the use of time series obtained as a result of ecosystem monitoring, combines the key features of both the knowledge-driven modeling (mechanistic models) and data-driven (DD) modeling. Using a KDD model, we reveal the phytoplankton growth-rate fluctuations in the ecosystem of the Naroch Lakes and determine the degree of phase synchronization between fluctuations in the phytoplankton growth rate and temperature variations. More specifically, we estimate a numerical value of the phase locking index (PLI), which allows us to assess how temperature fluctuations affect the dynamics of phytoplankton growth rates. Since, within the framework of KDD modeling, we directly include the time series obtained as a result of field measurements in the model equations, the dynamics of the phytoplankton growth rate obtained from the KDD model reflect the behavior of the lake ecosystem as a whole, and PLI can be considered as a holistic parameter.
Paying attention to the outcome of others' actions has dissociated effects on observer's peripersonal space representation and exploitation
Authors: Gigliotti Maria Francesca , Bartolo Angela , Coello Yann 
Published: June 2023

AbstractThe representation of peripersonal space (PPS representation) and the selection of motor actions within it (PPS exploitation) are influenced by action outcomes and reward prospects. The present study tested whether observing the outcome of others' actions altered the observer's PPS representation and exploitation. Participants (observers) performed a reachability-judgement task (assessing PPS representation) before and after having observed a confederate (actors) performing a stimuli-selection task on a touch-screen table. In the stimuli-selection task, the stimuli selected could either yield a reward or not, but the probability to select a reward-yielding stimulus was biased in space, being either 50%, 25% or 75% in the actor’s proximal or distal space. After the observation phase, participants performed the stimuli-selection task (assessing PPS exploitation), but with no spatial bias in the distribution of reward-yielding stimuli. Results revealed an effect of actors’ actions outcome on observers’ PPS representation, which changed according to the distribution of reward-yielding stimuli in the actors’ proximal and distal spaces. No significant effect of actors’ actions outcome was found on observers’ PPS exploitation. As a whole, the results suggest dissociated effects of observing the outcome of others’ actions on PPS representation and exploitation.
An exceptionally well-preserved monodominant fossil forest of Wataria from the lower Miocene of Japan
Authors: Nishino Megumi , Terada Kazuo , Uemura Kazuhiko , Ito Yuki , Yamada Toshihiro 
Published: June 2023

AbstractByttneriophyllum tiliifolium is a leaf fossil-species of the family Malvaceae that was distributed widely throughout Eurasia from the Miocene to the Pliocene. An affinity to some Malvadendrina subfamilies has been suggested for Byttneriophyllum-bearing plants, but remains to be clarified due to insufficient information on other organs. Here, we report an exceptional lower Miocene fossil locality in Japan where a monodominant forest of the wood fossil-species Wataria parvipora flourished. Notably, the forest floor was covered by a bed consisting almost exclusively of B. tiliifolium. We observed occurrence modes of B. tiliifolium in this bed that confirmed that these leaves were deposited parautochthonously. These observations imply a biological connection between B. tiliifolium and W. parvipora. The wood and leaf characters together might narrow the affinity of Byttneriophyllum-bearing plants down to Helicterioideae within the Malvadendrina, although it is also possible that Byttneriophyllum-bearing plants constitutes an extinct lineage which is characterized by a combination of morphological traits found in several extant lineages. Our results suggest that Byttneriophyllum-bearing plants started to inhabit swamps no later than the end of the early Miocene when the global temperature was getting warmer.
A randomized controlled trial for evaluating an occupational therapy self management intervention in adults with type 2 diabetes
Authors: Binesh Maryam , Shafaroodi Narges , Mirmohammadkhani Majid , Aghili Rokhsareh , Motaharinezhad Fatemeh , Khanipour Mahnoosh , Mehraban Afsoon Hassani 
Published: June 2023

AbstractThis study evaluated the efficacy of the Occupational Therapy Diabetes Self-Management intervention (OTDSM) to enhance glycemic stability and self-management skills in people with diabetes type-2. Based on this single-blind randomized trial, 30 subjects with diabetes type-2 were assigned to two groups of intervention and control. The intervention group received a 10-week program, consisting of four group visits and six individualized sessions. The control group received an individual session and three weekly phone calls. The primary study outcome, blood hemoglobin A1C, was measured before and three months after the study. The secondary outcome was assessed in terms of the participants’ self-management behaviors, self-efficacy, diabetes distress, depressive symptoms, and performance and satisfaction with daily activities. These outcomes were evaluated three times: before, one month into, and three months after the study. The study findings demonstrated significant differences between the two groups in the hemoglobin A1C levels, self-management behaviors, self-efficacy, and performance and satisfaction with daily routines after the intervention (P < 0.05). No significant differences existed between the groups for the extent of diabetes distress and depressive symptoms. Inclusion of occupational therapy protocol into the plan of care for people with diabetes can improve health outcomes by promoting their routine participation in self-management activities.
Cyclophilin B serum levels present variations across the menstrual cycle
Authors: Alvariño Rebeca , Gil-Mouce Cristina , Botana Manuel A. , Gegunde Sandra , González-Jartín Jesús , Vieytes Mercedes R. , Alfonso Amparo , Botana Luis M. 
Published: June 2023

AbstractCyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia-induced apoptosis. Previous studies related hormones like estradiol or prolactin to these proteins, however, their blood concentrations across the menstrual cycle have not been determined. In this work, eleven healthy women (BMI: 21.8 kg/m2) were monitored during a single menstrual cycle, making blood extractions at follicular, periovulatory and mid-luteal phases. Hormone and cyclophilin levels were determined in each phase. Statistical differences were determined by repeated measures ANOVA and estimated marginal means tests, or by Friedman and Dunn-Bonferroni tests for parametric and non-parametric variables, respectively. Bivariate correlations were evaluated with the Spearman coefficient. Cyclophilin B concentrations presented significant differences during the menstrual cycle (p = 0.012). The highest levels of this protein were found at follicular extraction, followed by a decrease at periovulatory phase and a slight increase at mid-luteal phase. Cyclophilin D showed the same profile, although statistical significance was not reached. This immunophilin exhibited a positive correlation with luteinizing hormone at periovulatory phase (r = 0.743, p = 0.009) and with follicle stimulating hormone at mid-luteal phase (r = 0.633, p = 0.036). This is the first study describing the changes in cyclophilin B concentrations across the menstrual cycle, as well as the association of luteinizing and follicle stimulating hormones with cyclophilin D. These results suggest a role of these proteins in the cyclic inflammatory events that affect female reproductive system that should be explored.
Multi-orbit lunar GNSS constellation design with distant retrograde orbit and Halo orbit combination
Authors: Wang K , Li Kezhao , Lv Shuaikang , Jiao YingXiang , Shen Yunyan , Yue Zhe , Xu Keke 
Published: June 2023

AbstractThe Moon is the closest natural satellite to mankind, with valuable resources on it, and is an important base station for mankind to enter deep space. How to establish a reasonable lunar Global Navigation Satellite System (GNSS) to provide real-time positioning, navigation, and timing (PNT) services for Moon exploration and development has become a hot topic for many international scholars. Based on the special spatial configuration characteristics of Libration point orbits (LPOs), the coverage capability of Halo orbits and Distant Retrograde Orbit (DRO) in LPOs is discussed and analyzed in detail. It is concluded that the Halo orbit with a period of 8 days has a better coverage effect on the lunar polar regions and the DRO has a more stable coverage effect on the lunar equatorial regions, and the multi-orbital lunar GNSS constellation with the optimized combination of DRO and Halo orbits is proposed by combining the advantages of both. This multi-orbital constellation can make up for the fact that a single type of orbit requires a larger number of satellites to fully cover the Moon, using a smaller number of satellites for the purpose of providing PNT services to the entire lunar surface. We designed simulation experiments to test whether the multi-orbital constellations meet the full lunar surface positioning requirements, and compare the coverage, positioning, and occultation effects of the four constellation designs that pass the test, and finally obtain a set of well-performing lunar GNSS constellations. The results indicate that the multi-orbital lunar GNSS constellation combining DRO and Halo orbits can cover 100% of the Moon surface, provides there are more than 4 visible satellites at any time on the Moon surface, which meets the navigation and positioning requirements, and the Position Dilution of Precision (PDOP) value is stable within 2.0, which can meet the demand for higher precision Moon surface navigation and positioning.
Effects of corn grain processing and protein source on calf performance, rumen fermentation, and blood metabolites
Authors: Jafarpour M. , Alikhani M. , Riasi A. , Omidi-Mirzaei H. , Khorvash M. , Ghaffari M. H. 
Published: June 2023

AbstractThe objective of this study was to investigate the effects of the interaction between corn grain processing and protein source on feed intake, growth performance, rumen fermentation, and blood metabolites of dairy calves. Seventy-two 3-day-old Holstein calves with an initial weight of 39.1 ± 3.24 kg were randomly assigned (n = 12 calves (6 male and 6 female) per treatment) to a 2 × 3 factorial arrangement of treatments with the factors of physical form of the corn grain [coarsely ground (CG) and steam-flaked (SF)] and protein type [canola meal (CAN), canola meal + soybean meal (CASY), and soybean meal (SOY)] were assigned. The study showed a significant correlation between corn grain processing method and protein source on calf performance, including starter feed intake, total dry matter intake (DMI), body weight, average daily gain (ADG), and feed efficiency (FE). The CG-CAN and SF-SOY treatments resulted in the highest feed intake and DMI in the post-weaning and total period, respectively. Interestingly, corn processing did not affect feed intake, ADG, and FE, but the highest ADG was observed at SF-SOY and CG-CAN. In addition, the interaction between corn processing method and protein source improved FE in calves fed CG-CAN and SF-SOY during the preweaning period and throughout the period. Although skeletal growth parameters were unchanged, calves fed SOY and CASY had greater body length and withers height than calves fed CAN during the preweaning period. Rumen fermentation parameters were also not affected by the treatments, except that calves fed CAN had a higher molar proportion of acetate than calves fed SOY and CASY. Corn grain processing and protein source did not affect glucose, blood urea nitrogen (BUN), or β-hydroxybutyrate (BHB) concentrations, except for the highest blood glucose level observed in the CAN treatment and the highest BUN level observed in the preweaned calves fed SOY. However, a two-way interaction was observed for BHB concentration, suggesting that ground corn grain resulted in higher BHB concentration during the preweaning and postweaning periods than steam-flaked corn. In summary, it is recommended to incorporate canola meal with ground corn or soybean meal with steam-flaked corn in calf starters to enhance calf growth.
Deep-learning approach to detect childhood glaucoma based on periocular photograph
Authors: Kitaguchi Yoshiyuki , Hayakawa Rina , Kawashima Rumi , Matsushita Kenji , Tanaka Hisashi , Kawasaki Ryo , Fujino Takahiro , Usui Shinichi , Shimojyo Hiroshi , Okazaki Tomoyuki , Nishida Kohji 
Published: June 2023

AbstractChildhood glaucoma is one of the major causes of blindness in children, however, its diagnosis is of great challenge. The study aimed to demonstrate and evaluate the performance of a deep-learning (DL) model for detecting childhood glaucoma based on periocular photographs. Primary gaze photographs of children diagnosed with glaucoma with appearance features (corneal opacity, corneal enlargement, and/or globe enlargement) were retrospectively collected from the database of a single referral center. DL framework with the RepVGG architecture was used to automatically recognize childhood glaucoma from photographs. The average receiver operating characteristic curve (AUC) of fivefold cross-validation was 0.91. When the fivefold result was assembled, the DL model achieved an AUC of 0.95 with a sensitivity of 0.85 and specificity of 0.94. The DL model showed comparable accuracy to the pediatric ophthalmologists and glaucoma specialists in diagnosing childhood glaucoma (0.90 vs 0.81, p = 0.22, chi-square test), outperforming the average of human examiners in the detection rate of childhood glaucoma in cases without corneal opacity (72% vs. 34%, p = 0.038, chi-square test), with a bilateral corneal enlargement (100% vs. 67%, p = 0.03), and without skin lesions (87% vs. 64%, p = 0.02). Hence, this DL model is a promising tool for diagnosing missed childhood glaucoma cases.
The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer
Authors: Yeo Xun Hui , Sundararajan Vignesh , Wu Zhengwei , Phua Zi Jin Cheryl , Ho Yin Ying , Peh Kai Lay Esther , Chiu Yi-Chia , Tan Tuan Zea , Kappei Dennis , Ho Ying Swan , Tan David Shao Peng , Tam Wai Leong , Huang Ruby Yun-Ju 
Published: June 2023

AbstractAXL is a receptor tyrosine kinase that is often overexpressed in cancers. It contributes to pathophysiology in cancer progression and therapeutic resistance, making it an emerging therapeutic target. The first-in-class AXL inhibitor bemcentinib (R428/BGB324) has been granted fast track designation by the U.S. Food and Drug Administration (FDA) in STK11-mutated advanced metastatic non-small cell lung cancer and was also reported to show selective sensitivity towards ovarian cancers (OC) with a Mesenchymal molecular subtype. In this study, we further explored AXL’s role in mediating DNA damage responses by using OC as a disease model. AXL inhibition using R428 resulted in the increase of DNA damage with the concurrent upregulation of DNA damage response signalling molecules. Furthermore, AXL inhibition rendered cells more sensitive to the inhibition of ATR, a crucial mediator for replication stress. Combinatory use of AXL and ATR inhibitors showed additive effects in OC. Through SILAC co-immunoprecipitation mass spectrometry, we identified a novel binding partner of AXL, SAM68, whose loss in OC cells harboured phenotypes in DNA damage responses similar to AXL inhibition. In addition, AXL- and SAM68-deficiency or R428 treatment induced elevated levels of cholesterol and upregulated genes in the cholesterol biosynthesis pathway. There might be a protective role of cholesterol in shielding cancer cells against DNA damage induced by AXL inhibition or SMA68 deficiency.
Endothelin-1 is associated with mortality that can be attenuated with high intensity statin therapy in patients with stable coronary artery disease
Authors: Lin Ruizhu , Junttila Juhani , Piuhola Jarkko , Lepojärvi E. Samuli , Magga Johanna , Kiviniemi Antti M. , Perkiömäki Juha , Huikuri Heikki , Ukkola Olavi , Tulppo Mikko , Kerkelä Risto 
Published: June 2023

Abstract
Background
All coronary artery disease (CAD) patients do not benefit equally of secondary prevention. Individualized intensity of drug therapy is currently implemented in guidelines for CAD and diabetes. Novel biomarkers are needed to identify patient subgroups potentially benefitting from individual therapy. This study aimed to investigate endothelin-1 (ET-1) as a biomarker for increased risk of adverse events and to evaluate if medication could alleviate the risks in patients with high ET-1.

Methods
A prospective observational cohort study ARTEMIS included 1946 patients with angiographically documented CAD. Blood samples and baseline data were collected at enrollment and the patients were followed for 11 years. Multivariable Cox regression was used to assess the association between circulating ET-1 level and all-cause mortality, cardiovascular (CV) death, non-CV death and sudden cardiac death (SCD).

Results
Here we show an association of circulating ET-1 level with higher risk for all-cause mortality (HR: 2.06; 95% CI 1.5–2.83), CV death, non-CV death and SCD in patients with CAD. Importantly, high intensity statin therapy reduces the risk for all-cause mortality (adjusted HR: 0.05; 95% CI 0.01–0.38) and CV death (adjusted HR: 0.06; 95% CI 0.01–0.44) in patients with high ET-1, but not in patients with low ET-1. High intensity statin therapy does not associate with reduction of risk for non-CV death or SCD.

Conclusions
Our data suggests a prognostic value for high circulating ET-1 in patients with stable CAD. High intensity statin therapy associates with reduction of risk for all-cause mortality and CV death in CAD patients with high ET-1.
Similar levels of deuteration in the pre-stellar core L1544 and the protostellar core HH211
Authors: Giers K. , Spezzano S. , Caselli P. , Wirström E. , Sipilä O. , Pineda J. E. , Redaelli E. , Bop C. T. , Lique F. 
Published: June 2023

Context. In the centre of pre-stellar cores, deuterium fractionation is enhanced due to low temperatures and high densities. Therefore, the chemistry of deuterated molecules can be used to probe the evolution and the kinematics in the earliest stages of star formation.
Aims. We analyse the deuterium fractionation of simple molecules, comparing the level of deuteration in the envelopes of the prototypical pre-stellar core L1544 in Taurus and the young protostellar core HH211 in Perseus.
Methods. We used single-dish observations of CCH, HCN, HNC, and HCO+ and their 13C-, 18O-, and D-bearing isotopologues, detected with the 20 m telescope at the Onsala Space Observatory. We derived the column densities, and subsequently the carbon isotopic ratios and deuterium fractions of the molecules. Additionally, we used radiative transfer simulations and results from chemical modelling to reproduce the observed molecular lines. We used new collisional rate coefficients for HNC, HN13C DNC, and DCN that consider the hyperfine structure of these molecules.
Results. For CCH, we find high levels of deuteration (10%) in both sources, consistent with other carbon chains. We find moderate deuteration of HCN (5–7%), with a slight enhancement towards the protostellar core. Equal levels of deuteration for HNC towards both cores (~8%) indicate that HNC is tracing slightly different layers compared to HCN. We find that the deuterium fraction of HCO+ is enhanced towards HH211, most likely caused by isotope-selective photodissociation of C18O. With radiative transfer, we were able to reproduce the observed lines of CCH, HCN, H13CN HNC, HN13C and DNC towards L1544 as well as CCH, H13CN HN13C DNC, H13CO+ HC18O+ and DCO+ towards HH211.
Conclusions. Similar levels of deuteration show that the deuterium fractionation is most probably equally efficient towards both cores, suggesting that the protostellar envelope still retains the chemical composition of the original pre-stellar core. The fact that the two cores are embedded in different molecular clouds also suggests that environmental conditions do not have a significant effect on the deuterium fractionation within dense cores. Our results highlight the uncertainties when dealing with 13C isotopologues and the influence of the applied carbon isotopic ratio. Radiative transfer modelling shows that it is crucial to include the effects of the hyperfine structure to reproduce the observed line shapes. In addition, to correctly model emission lines from pre-stellar cores, it is necessary to include the outer layers of the core to consider the effects of extended structures. In addition to HCO+ observations, HCN observations towards L1544 also require the presence of an outer diffuse layer where the molecules are relatively abundant.
How have music emotions been described in Google books? Historical trends and corpus differences
Authors: Xu Liang , Xu Min , Jiang Zehua , Wen Xin , Liu Yishan , Sun Zaoyi , Li Hongting , Qian Xiuying 
Published: June 2023

AbstractHuman records can assist us in understanding real descriptions and expected ideals of music. The present work examined how have music emotions been described in millions of Google books. In general, positive adjectives were more regularly used to describe music than negative adjectives, demonstrating a positivity bias in music. The emotional depiction of music has shifted over time, including a decrease in the frequency of emotional adjectives used in English books over the past two centuries, and a sudden surge in the usage of positive adjectives in simplified Chinese books during China’s Cultural Revolution. Negative adjectives were substantially less employed to describe music in simplified Chinese books than in English books, reflecting cultural differences. Finally, a comparison of different corpora showed that emotion-related adjectives were more frequently used to describe music in fictional literature.
All-magneto-optical grating bio-sensors based on enhanced transverse magneto-optical Kerr effect
Authors: Amanollahi Mansoureh , Zamani Mehdi 
Published: June 2023

Abstract
Herein, a novel structure composed of an all-magneto-optical periodic grating, without using noble metals, is presented to enhance the transverse magneto-optical Kerr effect (TMOKE). This is done by calculating the relative changes in the reflection amplitudes for the p-polarized wave using the finite element method (FEM) with COMSOL Multiphysics. Bio-sensing applications of the proposed structure can be possible by detecting alternation in the refractive index of the analyte medium through monitoring of the TMOKE. The simultaneous operation of the magneto-optic layer as a sensing layer is the advantage of our idea, where direct interaction with the analyte happens, leading to the suppression of the wave reflection amplitudes, and finally leading to extreme TMOKE in a magneto-optical (MO) grating (the TMOKE amplitudes are near 0.8 in this work). And since TMOKE shows a Fano-like shape, we calculate sensitivity and figure of merit (FoM) by fitting them together. This results in high sensitivity, and the value of the FoM is remarkable (between 2×103 and 3×103 refractive index unit) at resonance angles for different refractive indices, which makes our proposed structure able to be utilized for bio-sensing applications.