bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mültecilerde Sağlık Hizmetlerine Erişim
Authors: ALTINDİŞ Selma , İNCİ Mustafa Baran , ERKORKMAZ Ünal 
Published: January 2023

Amaç: Bu çalışma Sakarya’da yaşayan Suriye ve Irak kökenli göçmenlere sağlık hizmetlerine erişim durumunun ve erişimin önündeki engellerin belirlenmesi amacıyla yapıldı.
Gereç ve Yöntemler: Sakarya’da Ekim 2017-Ekim 2018 arasında yürütüldü. Araştırmanın evrenini Sakarya’da yaşayan Suriyeli ve Iraklı yabancı nüfus oluşturdu. Çalışmanın ilk bölümü için olasılıksız örnekleme yöntemlerinden uygun (convenience) örnekleme yöntemiyle 500 kişi çalışmaya alındı. Göçmenlerin çokça ziyaret ettiği yerlerde Arapça ve Türkçe konuşabilen anketörler görevlendirildi. Veriler yüz yüze görüşme yöntemiyle toplandı. Araştırmanın nitel kısmında Arapça ve Türkçe bilen çevirmenler yüz yüze mülakat tekniğiyle 50 kişiden sağlık kurumlarına erişimde yaşadıkları sorunlarla ilgili deneyimler ve düşünceler elde etti. Ek olarak göçmenlerin hastane/polikliniklerde yaşadıkları sorunlar için gözlem tekniğiyle 50 saatlik gözlem yapıldı ve gözlem formları dolduruldu.
Bulgular: Katılımcıların %51,40’ü Iraklı, %48,60’sı Suriyeliydi. Katılımcıların %50,60’sı kadın; genel yaş ortalaması 35,90±11,30 (17,00-72,00) yıldı. Katılımcıların %65,60’sı sağlık sistemi işleyişini öğrenmekte sorun yaşadığını, %71,40’ü sağlık kuruluşlarındaki bilgilendirme yazılarıyla tabelalarını anlayamadıklarını, %81,20’si randevu alma sorunları olduğunu, %77,80’i hekimle tanı/tedavileri konusunda anlaşamadığını ve %51,40’ü ise eczanede ilaç temini sırasında alınan ilacın kullanımına ilişkin sorun yaşadığını bildirdi. Çalışmanın ikinci bölümünde; katılımcıların çoğunluğu muayene için randevu almakta zorluk yaşadıklarını, bilgilendirme yazılarıyla tabelaları anlamakta zorluk çektiklerini, eczanelerde dil engeli yaşadıklarını belirtti. Araştırmanın üçüncü bölümünde Sakarya Üniversitesi Eğitim ve Araştırma Hastanesinde yapılan gözlemlerde en sık karşılaşılan talepler hastane bölümlerinin yerlerini sorma ve yönlendirme talepleriydi.
Sonuç: Göçmenlerin sağlık hizmeti alımı esnasında yaşadıkları dil kaynaklı iletişim sorunlarının ve bunlardan kaynaklanan olumsuzlukların önüne geçmek için sağlık kuruluşlarında dil bariyerini aşmaya yönelik hem insan gücü yönünden hem de fiziki anlamda düzenlemeler yapılmalıdır.
Peran Kader Juru Pamantau Jentik (Jumantik) Mandiri dalam Upaya Pencegahan Penyakit DBD di Kelurahan Talise Valangguni Kota Palu
Authors: Syam Dedi Mahyudin , Aryanti Ros , Christine Christine 
Published: January 2023

Efforts to prevent and control dengue fever in Palu City are still inadequate, the results of a survey carried out by officers show that community participation in eradicating mosquito nests (PSN), especially in closing, draining and burying (3M) and plus (plus) activities such as: sprinkling larvacide larvae, keeping larvae-eating fish. This effort involves larva monitoring interpreters (jumantik) but the role of independent jumantik is not yet optimal. This is indicated by the larva free rate which is still below the standard of 85%. The target of this community service activity is the Jumantik Mandiri Cadre at Citra Permai Indah 3 Complex (CPI3) in Talise Valangguni Village, Palu City, totaling 25 people. The method used is lecture and question and answer. Lectures were conducted to disseminate information on dengue prevention, how to monitor larvae and field practice in the form of larva monitoring in the CPI3 housing complex. The activity was carried out from May to June 2022 at the CPI-3 housing complex, Talise Valangguni Village, Palu City. The results of the activity show the role of the independent Jumantik Cadre. After receiving education and guidance from the service team, it increased up to 100% and the larva-free rate (ABJ) in monitoring from the first week-1 to week-3 always increased up to 98%. Providing education can increase the role of independent jumantik cadres and effectively increase the larva free rate.
ABSTRAK
Upaya pencegahan dan pengendalian penyakit DBD di Kota Palu masih belum memadai, hasil survei yang telah dilaksanakan oleh petugas, menunjukkan bahwa partisipasi masyarakat dalam pemberantasan sarang nyamuk (PSN) terutama dalam kegiatan menutup, menguras dan mengubur (3M) dan ditambah (plus) seperti: menaburkan larvasida pembasmi jentik, memelihara ikan pemakan jentik. Upaya ini melibatkan juru pemantau jentik (jumantik) namun peran jumantik mandiri belum optimal. Hal tersebut ditandai dengan Angka Bebas Jentik masih dibawah standar 85%. Sasaran kegiatan pengabdian kepada masyarakat ini adalah Kader Jumantik Mandiri Komplek Citra Permai Indah 3 (CPI3) Di Kelurahan Talise Valangguni Kota palu berjumlah 25 orang. Metode yang digunakan adalah ceramah dan tanya jawab. Ceramah dilakukan untuk mensosialisasikan informasi tentang, Pencegahan DBD, cara melakukan monitoring jentik dan praktek lapangan berupa pemantauan jentik di komplek perumahan CPI3. Kegiatan dilaksanakan Mei – Juni 2022 Di Komplek perumahan CPI-3 Kelurahan Talise Valangguni Kota palu. Hasil kegiatan menunjukkan Peran Kader Jumantik Mandiri Setelah memperoleh edukasi dan bimbingan dari tim pengabdi mengalami peningkatan hingga 100% serta Angka Bebas Jentik (ABJ) dalam pemantauan mulai dari minggu-1 pertama sampai minggu-3 selalu mengalami peningkatan hingga mencapai 98%.Pemberian edukasi dapat meningkatkan peran kader jumantik mandiri serta efektif meningkatkan Angka bebas Jentik.
Pelayanan Informasi dan Edukasi Tentang Cara Kerja Obat Melalui Media Sosial Instagram
Authors: Sianipar Erlia Anggrainy , Arrang Sherly Tandi , Cokro Fonny 
Published: January 2023

The limited knowledge of community regarding drugs is still become a root cause in irrationality treatment. Information and education services about drug action is an important thing that should be known by the community as drug consumers so the rational treatment will be realized and misuse and errors in using drugs can be avoided. The aims of this program are to increase public knowledge about drug action and to find out the most favourite educational topic. Education is provided through the Instagram social media account @pioheal.fkikuaj which is easily accessible by social media users. Knowledge is presented on e-flyer and posted once a week for eight consecutive weeks from May to July 2021. The activities were evaluated through a questionnaire by the e-flyer readers. The results showed that 100% of the readers stated that their knowledge had increased after reading the e-flyer with an average increase ranging from 50-75% and as many as 80% of readers get a score of 70-100 (good). The most favorite educational topic was the drug action on the autonomic nervous system. Based on these results, we concluded that this information and educational services have succeeded in increasing the knowledge of social media users, especially about how drugs work. However, the evaluation of behavioral changes in the community regarding rational drug use needs further investigation.
ABSTRAK
Keterbatasan pengetahuan masyarakat terkait obat masih menjadi akar masalah dalam ketidakrasionalan pengobatan. Pelayanan informasi dan edukasi tentang cara kerja obat merupakan hal penting yang hendaknya diketahui oleh masyarakat sebagai konsumen obat sehingga pengobatan yang rasional dapat terwujud dan penyalahgunaan serta penggunaan yang salah terhadap obat dapat dihindari. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan masyarakat tentang cara kerja obat dan mengetahui topik edukasi yang paling diminati. Pemberian edukasi dilakukan melalui akun media sosial Instagram @pioheal.fkikuaj yang mudah diakses oleh para pengguna media sosial. Pengetahuan disajikan dalam bentuk e-flyer dan diposting setiap satu minggu sekali selama delapan minggu berturut-turut mulai pada bulan Mei hingga bulan Juli 2021. Kegiatan dievaluasi melalui kuesioner oleh pembaca e-flyer. Hasil kuesioner menunjukkan bahwa 100% pembaca menyatakan pengetahuannya meningkat setelah membaca e-flyer dengan rata-rata peningkatan berkisar antara 50-75% dan sebanyak 80% pembaca mendapatkan nilai 70-100 (baik). Topik edukasi yang paling diminati adalah tentang obat-obat yang bekerja pada sistem saraf otonom. Berdasarkan hasil tersebut, kami menyimpulkan bahwa pelayanan informasi dan edukasi ini berhasil meningkatkan pengetahuan pengguna media sosial terutama mengenai cara kerja obat. Namun, evaluasi terhadap perubahan perilaku di masyarakat terkait penggunaan obat yang rasional perlu diteliti lebih lanjut.
Upaya Peningkatan Imunitas Tubuh melalui Edukasi Pangan dan Gizi bagi Pegawai dan Dosen di LLDIKTI Wilayah VIII
Authors: Kusumawati I Gusti Ayu Wita , Nursini Ni Wayan , Yogeswara Ida Bagus Agung , Sulistyadewi Ni Putu Eny , Puspaningrum Dylla Hanggaeni Dyah , Wiradnyani Ni Ketut , Mantra Ida Bagus Ketut , Kusumaningsih Purwaningtyas , Mustika I Gede 
Published: January 2023

The Covid 19 pandemic and unhealthy life style may lead to depression and anxiety followed by a decreasing of immune system. A healthy diet affects a person’s health and immune system. Objective: To provide education to the community, especially employees and lecturers in the LLDIKTI region VIII work environment, regarding food consumption and nutrition that can prevent stress and increase endurance during a pandemic. Methods: The activity begins with preparation, implementation and evaluation. Education is carried out using virtual media through zoom meetings, which are in the form of webinar series containing lectures and discussions. At the beginning of the activity, partners are given a pre-test and at the end of the discussion partners are given a post-test. Community service activities are carried out from October 13, 2021, to November 13, 2021. The evaluation was carried out using a knowledge questionnaire based on the material presented by the speaker. The results of the community service activities showed an increase in partner knowledge about food and nutrition consumption that can prevent stress and increase endurance during a pandemic. Suggestion: It is necessary to conduct training and assistance in hygiene food processing to produce processed innovations that can be used to increase body immunity.
Decellularized vascularized bone grafts: A preliminary in vitro porcine model for bioengineered transplantable bone shafts
Authors: Rougier Guillaume , Maistriaux Louis , Fievé Lies , Xhema Daela , Evrard Robin , Manon Julie , Olszewski Raphael , Szmytka Fabien , Thurieau Nicolas , Boisson Jean , Kadlub Natacha , Gianello Pierre , Behets Catherine , Lengelé Benoît 
Published: January 2023

Introduction: Durable reconstruction of critical size bone defects is still a surgical challenge despite the availability of numerous autologous and substitute bone options. In this paper, we have investigated the possibility of creating a living bone allograft, using the perfusion/decellularization/recellularization (PDR) technique, which was applied to an original model of vascularized porcine bone graft.Materials and Methods: 11 porcine bone forelimbs, including radius and ulna, were harvested along with their vasculature including the interosseous artery and then decellularized using a sequential detergent perfusion protocol. Cellular clearance, vasculature, extracellular matrix (ECM), and preservation of biomechanical properties were evaluated. The cytocompatibility and in vitro osteoinductive potential of acellular extracellular matrix were studied by static seeding of NIH-3T3 cells and porcine adipose mesenchymal stem cells (pAMSC), respectively.Results: The vascularized bone grafts were successfully decellularized, with an excellent preservation of the 3D morphology and ECM microarchitecture. Measurements of DNA and ECM components revealed complete cellular clearance and preservation of ECM’s major proteins. Bone mineral density (BMD) acquisitions revealed a slight, yet non-significant, decrease after decellularization, while biomechanical testing was unmodified. Cone beam computed tomography (CBCT) acquisitions after vascular injection of barium sulphate confirmed the preservation of the vascular network throughout the whole graft. The non-toxicity of the scaffold was proven by the very low amount of residual sodium dodecyl sulfate (SDS) in the ECM and confirmed by the high live/dead ratio of fibroblasts seeded on periosteum and bone ECM-grafts after 3, 7, and 16 days of culture. Moreover, cell proliferation tests showed a significant multiplication of seeded cell populations at the same endpoints. Lastly, the differentiation study using pAMSC confirmed the ECM graft’s potential to promote osteogenic differentiation. An osteoid-like deposition occurred when pAMSC were cultured on bone ECM in both proliferative and osteogenic differentiation media.Conclusion: Fully decellularized bone grafts can be obtained by perfusion decellularization, thereby preserving ECM architecture and their vascular network, while promoting cell growth and differentiation. These vascularized decellularized bone shaft allografts thus present a true potential for future in vivo reimplantation. Therefore, they may offer new perspectives for repairing large bone defects and for bone tissue engineering.
Development of a dual-component infection-resistant arterial replacement for small-caliber reconstructions: A proof-of-concept study
Authors: Zia Sonia , Djalali-Cuevas Adrian , Pflaum Michael , Hegermann Jan , Dipresa Daniele , Kalozoumis Panagiotis , Kouvaka Artemis , Burgwitz Karin , Andriopoulou Sofia , Repanas Alexandros , Will Fabian , Grote Karsten , Schrimpf Claudia , Toumpaniari Sotiria , Mueller Marc , Glasmacher Birgit , Haverich Axel , Morticelli Lucrezia , Korossis Sotirios 
Published: January 2023

Introduction: Synthetic vascular grafts perform poorly in small-caliber (&lt;6mm) anastomoses, due to intimal hyperplasia and thrombosis, whereas homografts are associated with limited availability and immunogenicity, and bioprostheses are prone to aneurysmal degeneration and calcification. Infection is another important limitation with vascular grafting. This study developed a dual-component graft for small-caliber reconstructions, comprising a decellularized tibial artery scaffold and an antibiotic-releasing, electrospun polycaprolactone (PCL)/polyethylene glycol (PEG) blend sleeve.Methods: The study investigated the effect of nucleases, as part of the decellularization technique, and two sterilization methods (peracetic acid and γ-irradiation), on the scaffold’s biological and biomechanical integrity. It also investigated the effect of different PCL/PEG ratios on the antimicrobial, biological and biomechanical properties of the sleeves. Tibial arteries were decellularized using Triton X-100 and sodium-dodecyl-sulfate.Results: The scaffolds retained the general native histoarchitecture and biomechanics but were depleted of glycosaminoglycans. Sterilization with peracetic acid depleted collagen IV and produced ultrastructural changes in the collagen and elastic fibers. The two PCL/PEG ratios used (150:50 and 100:50) demonstrated differences in the structural, biomechanical and antimicrobial properties of the sleeves. Differences in the antimicrobial activity were also found between sleeves fabricated with antibiotics supplemented in the electrospinning solution, and sleeves soaked in antibiotics.Discussion: The study demonstrated the feasibility of fabricating a dual-component small-caliber graft, comprising a scaffold with sufficient biological and biomechanical functionality, and an electrospun PCL/PEG sleeve with tailored biomechanics and antibiotic release.
A bibliometric analysis of the application of stem cells in glaucoma research from 1999 to 2022
Authors: Tao Yuanyuan , Zhang Qian , Meng Ming , Huang Jufang 
Published: January 2023

Background: Glaucoma, a neurodegenerative disease of the retina, is the leading cause of irreversible blindness. Stem cells have therapeutic potential for glaucoma. However, few bibliometric studies have been published in this field. Concerning a visual map, this article aims to characterize the research context, cooperation relationship, hotspots, and trends concerning the application of stem cells in glaucoma research.Methods: Publications focusing on stem cell research and glaucoma were retrieved from the Web of Science Core Collection. VOSviewer, CiteSpace, Microsoft Excel, and Scimago Graphica were used to map the contributions of countries or regions, authors, organizations, and journals. Journal Impact Factor data were obtained from the Web of Science Core Collection. We analyzed the tendencies, hotspots, and knowledge networks using VOSviewer, and CiteSpace.Results: We analyzed 518 articles published from 1999 through 2022. In the first decade, the number of articles in this field increased slowly, and there was a marked acceleration in publication frequency after 2010. The United States, China, and England were the main contributors. Yiqin Du was the most prolific author, and among the top 10 prolific writers, Keith R. Martin’s work was cited most frequently. Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Cornea published the most articles in this domain. The three most commonly co-cited journals were Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Proceedings of the National Academy of Sciences of the United States of America. The Central South University, the University of Pittsburgh, and the National Institutes of Health National Eye Institute were highly prolific institutions in this research area. Our keywords analysis with VOSviewer suggested directions of future research and yielded the following recent key themes, extracellular vesicles, exosomes, mitochondria, growth factors, oxidative stress, and ocular diseases. Four co-cited references had a citation burst duration until 2022.Conclusion: With improvements in overall quality of life and demographic transitions toward population aging, research and clinical focus on eye care has increased, with glaucoma as a key area of emphasis. This study added to our understanding of the global landscape and Frontier hotspots in this field.
The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD
Authors: Darand Mina , Salehi-Abargouei Amin , Vahidi Mehrjardi Mohammad Yahya , Feizi Awat , Seyedhossaini Seyed Mustafa , Askari Gholamreza 
Published: January 2023

IntroductionThe present study aimed to investigate the association of the paraoxonase 1 (PON1) Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD.MethodsThis cross-sectional study was conducted on 428 patients undergoing angiography. The data related to demographic information and physical activity were collected by valid and reliable questionnaires. The PON-1 genotypes were detected by the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) technique. The Gensini and SYNTAX score, anthropometric measurements, and biochemical and clinical parameters were measured by standard protocols.Results and discussionFindings indicated that the odds of obesity was significantly higher in people with the RR genotype compared to the QQ genotype carriers (OR: 2.95 CI: 1.25–6.93, P = 0.014) and also odds of low high-density lipoprotein cholesterol (HDL-C) was marginally higher (OR: 2.31 CI: 0.97–5.49, P = 0.056). There was no significant association between other CAD risk factors with PON1 Q192R polymorphism (P &gt; 0.05). Further analysis showed a significant interaction between sex and 192QR (P = 0.019) and 192 RR (P = 0.007) genotypes on body mass index (BMI). More specifically, the risk of obesity in men carrying the RR genotype was 3.38 times (OR: 3.38 CI: 1.08–10.58, P = 0.036). Also, a significant joint effect of the RR genotype and sex on HDL-C was seen (P = 0.003). The stratification based on sex showed that the risk of low HDL-C is significantly higher in women carrying the RR genotype (OR: 6.18 CI: 1.21–31.46, P = 0.028). A marginal sex-genotype interaction was also found in the risk of elevated alanine aminotransferase (ALT) (P = 0.057). In summary, the findings showed that the risk of obesity and low HDL-C was higher in people carrying the RR genotype. On the other hand, a Q192R polymorphism-sex interaction was observed on the risk of obesity, elevated ALT, and low HDL-C.
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan
Authors: Winicki Nolan M. , Nanavati Alay P. , Morrell Christopher H. , Moen Jack M. , Axsom Jessie E. , Krawczyk Melissa , Petrashevskaya Natalia N. , Beyman Max G. , Ramirez Christopher , Alfaras Irene , Mitchell Sarah J. , Juhaszova Magdalena , Riordon Daniel R. , Wang Mingyi , Zhang Jing , Cerami Anthony , Brines Michael , Sollott Steven J. , de Cabo Rafael , Lakatta Edward G. 
Published: January 2023

BackgroundAging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic peptide sequence within the cardioprotective domain of erythropoietin, mediates tissue protection by reducing inflammation and fibrosis. Age-associated cardiac inflammation is linked to structural and functional changes in the heart, including mitochondrial dysfunction, impaired proteostasis, hypertrophic cardiac remodeling, and contractile dysfunction. Can ARA290 ameliorate these age-associated cardiac changes and the severity of frailty in advanced age?MethodsWe conducted an integrated longitudinal (n = 48) and cross-sectional (n = 144) 15 months randomized controlled trial in which 18-month-old Fischer 344 x Brown Norway rats were randomly assigned to either receive chronic ARA290 treatment or saline. Serial echocardiography, tail blood pressure and body weight were evaluated repeatedly at 4-month intervals. A frailty index was calculated at the final timepoint (33 months of age). Tissues were harvested at 4-month intervals to define inflammatory markers and left ventricular tissue remodeling. Mitochondrial and myocardial cell health was assessed in isolated left ventricular myocytes. Kaplan–Meier survival curves were established. Mixed ANOVA tests and linear mixed regression analysis were employed to determine the effects of age, treatment, and age-treatment interactions.ResultsChronic ARA290 treatment mitigated age-related increases in the cardiac non-myocyte to myocyte ratio, infiltrating leukocytes and monocytes, pro-inflammatory cytokines, total NF-κB, and p-NF-κB. Additionally, ARA290 treatment enhanced cardiomyocyte autophagy flux and reduced cellular accumulation of lipofuscin. The cardiomyocyte mitochondrial permeability transition pore response to oxidant stress was desensitized following chronic ARA290 treatment. Concurrently, ARA290 significantly blunted the age-associated elevation in blood pressure and preserved the LV ejection fraction. Finally, ARA290 preserved body weight and significantly reduced other markers of organism-wide frailty at the end of life.ConclusionAdministration of ARA290 reduces cell and tissue inflammation, mitigates structural and functional changes within the cardiovascular system leading to amelioration of frailty and preserved healthspan.