bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained virological response 12 versus sustained virological response 24 as evaluation endpoints in chronic hepatitis C virus Egyptian patients treated with sofosbuvir-based regimens
Authors: Elsabaawy Maha M. , Gameel Khalid , Eldemerdash Heba , Zakareia Talaat , Eltahawy Mahmoud , Albert Marry , Fekry Marwa , Ouda Enas , Elshazly Helmy , Eljaky Ashraf 
Published: September 2023

Abstract
Background
The recommended reliance on 12 weeks posttreatment sustained virological response (SVR12) instead of SVR24 was validated for treatment evaluation.

Aim
Judging claimed concordance between SVR12 and SVR24.

Patients and methods
In a prospective study, 91 patients received sofosbuvir (SOF)+interferon+ribavirin (RV) for 12 weeks; 52 patients received SOF+RV for 24 weeks; and 56 patients received SOF+simeprevir for 12 weeks. Demographic and laboratory data, transient elastography, treatment regimens, hepatitis C virus RNA at week 4, week 12, and SVR12 and were reported. Patients who failed to achieve undetectable hepatitis C virus RNA at the end of therapy were excluded.

Results
Concordance between SVR12 and SVR24 was 96.5%, with a positive predictive value of 96.4%. Regarding treatment groups it was found to be 95.6% for SVR24 in SOF+interferon+RV-treated patients, 94.2% in SOF+RV-treated patients, and 100% concordance in SOF+simeprevir-treated patients with insignificant values (P=0.2). In spite of nonsignificance, the reported seven (3.5%) relapsers were mainly male gender (five cases, P=0.9), naïvely treated (five cases, P=0.6), achieved rapid virological response (five cases, P>0.005), with advanced fibrosis (F4) by fibroscan (five cases, P=0.7). Regression analysis failed to detect any predictors of relapse.

Conclusion
In spite of the high grade of concordance between SVR12 and SVR24, the reported rate of relapsers necessitates the backward commitment to SVR24 as a reliable primary endpoint of treatment response evaluation.
Comparing outcome of formal and informal remediation programs in children with central auditory processing disorder
Authors: Oraky Samah M. , Tawfik Somaia , Salama Mohamed , Mohamed Enass S. 
Published: September 2023

Abstract
Aim
The aim of this study was to compare the outcome of central auditory processing rehabilitation when using two different strategies:
In the first strategy, computer-based remediation program (temporal processing and phonemic awareness training) was used.
In the second strategy, informal remediation program (temporal processing and phonemic awareness training) was used.

Patients and methods
Fifty children with learning disability due to Central Auditory Processing Disorder (CAPD) were selected from primary schools in Assiut city. They were subjected to psychophysical test battery. It comprised dichotic digits, pitch pattern sequence, auditory fusion test and electrophysiological test (cortical P1). They were divided into two equal groups (A and B): group A received the formal auditory training (AT) and group B received the informal AT for a minimum duration of 2 months. Re-evaluation of those children was performed using the same test battery used in the diagnosis.

Results
There was a statistically significant difference in all psychophysical tests and electrophysiological P1. Subjective improvement was noticed also at the level of the questionnaire.

Conclusion
Both formal and informal remediation programs used in this study proved to be effective and promising AT strategies for ameliorating central auditory disorder.
The role of simple office-based surgery in small central tympanic membrane perforation
Authors: El-Rasheedy Abdel-Latif I. , Abdel-Fattah Ayman A. , El-Naga Heba A. Abo , El-Barbary Mustafa M. 
Published: September 2023

Abstract
Objective
The aim of this study was to evaluate the outcome of simple office-based surgery in small central tympanic membrane (TM) perforation.

Background
The purpose of closure of TM perforations is to restore the continuity of the TM in order to improve hearing and decrease the risk of middle ear infections. Rapid and cost-effective procedures like chemical cauterization and fat plug myringoplasty have been found to be effective in healing small central perforations with significant hearing improvement.

Patients and Methods
Our prospective study was carried out on 40 patients aged more than 15 years with dry small central persistent perforation during the period spanning from April 2017 to March 2018, divided in two groups: group A (20 patients underwent fat graft myringoplasty) and group B (20 patients underwent chemical cautery of the edge of perforation).

Results
Our study included 26 male patients and 14 female patients; the mean age was 27.2 ±9.3 years. Our study showed a 70% success rate in the healing of TM perforation in group A while there was a 55% success rate in group B.

Conclusion
From our study, we found that the two procedures are easy to perform, reliable with a satisfactory outcome, simple, rapid, risk free, and also lessen the financial burden and morbidity on the patient.
Effect on postoperative pain after topical application of local anesthetics in the tonsillar fossa after tonsillectomy
Authors: El Daly Ahmed , El Naby Moustafa Abd , Emad Pola 
Published: September 2023

Abstract
Background
Tonsillectomy is one of the most commonly performed surgeries in ENT practice. Despite improvements in anesthetic and surgical techniques, post-tonsillectomy morbidities continue to be a significant clinical concern. Pain is the cause of most of the postoperative morbidity after tonsillectomy. An effective pain therapy to block or modify the physiological responses to stress has become an essential component of modern pediatric anesthesia and surgical practice.

Aim
The present study compares the results between the effect of lidocaine 2% infiltration, lidocaine 10 % spray, and bupivacaine 0.5% spray in the tonsillar bed after tonsillectomy on postoperative pain.

Materials and methods
The study included a total of 120 patients aged 5–18 years who were candidates for tonsillectomy at the Otorhinolaryngology Department of Alexandria Main University Hospital. The patients were randomly divided into three groups of 40 patients each. Group A received lidocaine 2% (Xylocaine) peritonsillar infiltration 2ml in one tonsillar bed and posterior pillar; group B received lidocaine 10% (Xylocaine) spray 2 puff in one tonsillar bed; group C received bupivacaine 0.5% (Marcaine) solution 2ml in one tonsillar bed spray by syringe and the other tonsillar bed in each group receives pack with similar amounts of normal saline for 5 min as a control group after tonsillectomy before recovery from anesthesia.

Results
There was no statistical difference between the three studied groups as regards age and sex. There is significant statistical difference according to the frequency of throat pain and ear pain by comparing cases and controls of each group within the first 24 h after surgery. It appears that increased frequency of postoperative throat pain and ear pain is present with the control side (saline).

Conclusion
Topical application of the tonsillar bed with a local anesthetic after tonsillectomy results in significant reduction of postoperative throat pain and referred otalgia and should be used during surgery for tonsillectomy.
Surgical complications and morbidity in cochlear implantation
Authors: Sefein Ihab K. 
Published: September 2023

Abstract
Introduction
Cochlear implantation (CI) has been established worldwide as the surgical treatment for individuals with bilateral severe-to-profound hearing loss. This is a safe and standard procedure in the hands of experienced implant surgeons. Complications due to surgery are minimal and are often encountered in cases of congenital anomalies of the temporal bone and inner ear.

Patients and Methods
All patients receiving CI at our institution between 2014 and 2015 were included in the study.

Aim
The aim of this study was to report the frequency of surgical complications following 112 consecutive CIs in 102 children and 10 adults in the National Hearing and Speech Institute (HIS), Cairo, Egypt. The international consensus on the reporting of CI complications proposed by Hansen and colleagues was used and evaluated.

Results
In all, 112 implantations were performed in 102 pediatric and 10 adult patients. Overall, complications occurred in 21 (18.75%) patients, including minor complications in nine (8.03%) and major complications in 12 (10.71%) cases. Complications were delayed in nine (8.03%) cases. No death was attributed to device implantation. Major complications occurred in 12 cases, which included misplaced electrodes in two cases, cerebrospinal fluid leak (gusher) in four cases, labyrinthitis ossificans in one patient, magnet displacement in one case (chronic suppurative otitis media), central perforation in one case, seroma and hematoma (severe cutaneous infections) in one case, wound infection in one case, and persistent pain/discomfort (migration) in one case.

Conclusion
Complications of CI are more common in children than in adults with trauma as a major factor. Inner ear malformations should prompt specific preventive management. CI in young children did not appear to be a risk factor in this study.
KASTAMONU İLİNDEKİ ÖLÜMLERİN NEDENLERİNE GÖRE DAĞILIMI (2018-2021)
Authors: DURAN Celalettin , DİLER Zühal , YAZAN Suat 
Published: September 2023

Bu çalışmada, Kovid-19 pandemi yıllarındaki (2020, 2021) ve öncesi yıllardaki (2018, 2019) ölümlerin Kastamonu ili ilçelerine göre dağılımları incelenmiştir. Çalışma kapsamında, Türkiye İstatistik Kurumunun (TÜİK) ölüm istatistiklerine ilişkin verileri kullanılmıştır. Kaba ölüm hızı, açıklanan ölüm nedenleri, Kovid-19 nedenli ölümler, intihar vakaları, kentsel ve kırsal yörelerdeki ölümlere ilişkin istatistikler, ilçelere ve yıllara (2018-2021) göre karşılaştırılmıştır.
Kastamonu ili, yaşlı nüfus oranının yüksek olduğu illerden biridir. Kaba ölüm hızı, pandemi yıllarında (2020-2021) belirgin olarak artmıştır. Bu artış, Türkiye ortalamasının çok üzerindedir. Kırsal nitelik taşıyan ilçe yerleşimlerindeki kaba ölüm oranları, daha yüksektir. Kaba ölüm oranının en yüksek olduğu ilçe, Pınarbaşı (binde 22,7) ilçesidir. En düşük olduğu ilçe ise, Merkez (binde 7,7) ilçedir. Kovid-19 pandemi yıllarını oluşturan dönem (2020 ve 2021) ile öncesi yılları oluşturan dönem (2018 ve 2019) karşılaştırıldığında; 65 yaş üstü ölümlerin tüm ölümler içindeki oranlarında, cinsiyete bağlı ölüm oranlarında ve yerleşim yerine bağlı ölüm oranlarında belirgin bir farklılık bulunamamıştır. Bununla birlikte, ölümlerin nedenlerine göre gruplandırıldığı ölüm oranlarında, yıllar itibariyle ve ilçeler bazında dikkat çekici farklılıklar vardır.
Tito Brandsma e experiência de Deus em meio ao caos do nazismo
Authors: Vilela da Silva Renê Augusto 
Published: September 2023

O presente artigo apresenta a experiência de Deus diante do Nazismo tendo como referência os escritos de Tito Brandsma, frade carmelita e jornalista. Sabe-se que a busca pelo sagrado e o refúgio na fé nos apresenta diversas experiências que são capazes de fortalecer a humanidade mesmo diante de desafios e atrocidades. O testemunho espiritual e místico de Tito Brandsma é um eco dos tempos modernos que apresenta os sinais de Deus em meio aos novos desafios da humanidade: a busca pelo sentido da vida; a esperança na própria humanidade; defesa da verdade; defesa da fé; entre temas que refletidos pelo jornalista e mártir do Nazismo. Tito Brandsma compreende a importância da humanidade se integrar com a Criação que ofertará a oportunidade de entender os anseios da humanidade e a busca pelo transcendente mesmo diante da dor, das incertezas, da falta de valores. A espiritualidade do frade carmelita nos mostra a importância da vida de oração como uma profunda intimidade com Deus que habita no coração dos humanos e que deve ser transparecida pela esperança e pela caridade. Para o artigo utilizaremos de bibliografia e apresentaremos um caminho que descreve a experiência de fé em meio ao Nazismo e de compreender o verdadeiro sentido de humanidade em meio ao caos. Trata-se de uma experiência e descrição de viver a unidade entre o humano e divino.
Perlindungan Konsumen E-Commerce Dalam Kerangka Masyarakat Ekonomi Asean (MEA)
Authors: Sommaliagustina Desi , Citra Helfira , Wahyuni Sry 
Published: September 2023

The development of information technology with the transformation that occurs has resulted in the development of trading activities. It's not just about what is traded but also the method of trading. The trading method in question is a transaction through electronic media or what is known as electronic commerce or e-commerce. The development of e-commerce is in line with the growth of the internet. This is because e-commerce runs through the internet network. The presence of the ASEAN Economic Community (EAC) is an integration of countries in the Southeast Asian region in particular, which aims to reduce the gap between ASEAN countries in terms of economic growth. In addition to the positive impact of e-commerce trading, there are also problems, including those related to defaults that occur in the future. So that clear regulations are needed regarding dispute resolution between ASEAN member countries.
Pengaruh Perputaran Persediaan Dan Perputaran Piutang Terhadap Likuiditas Pada Perusahaan Sub Sektor Farmasi Yang Terdaftar Di Bursa Efek Indonesia Periode 2015-2019
Authors: Ramadani Sri , Afrianti Rini , Yusnita Irni 
Published: September 2023

This research was conducted to find out how the influence of inventory turnover and accounts receivable turnover on liquidity in pharmaceutical sub sector companies listed on the Indonesian Stock Exchange for the period 2015-2019. The population in the study were all in pharmaceutical sub sector companies listed on the indonesian stock exchange for the period 2015-2019, which numbered 10 companies. Based on the criteria for sampling techniques, the samples studied were 10 companies in pharmaceutical sub sector companies listed on the indonesian stock exchange for the period 2015-2019. Data processing techniques used are multiple regression analysis techniques with a significance level of 0,05. Data processing is done using the SPSS 22 computer program for window. Based on the results of data processing shows that silmutaneously inventory turnover and accounts receivable turnover of the company have a significant effect on firm value with a calculated F value of 12,621 with and a significance value of 0,000. Partially inventory turnover has no significant effect on firm value with a calculated T value of 1,479 and a significance value of 0,146. Partially the accounts receivable turnover has a significant effect on firm value with a calculated T value of 2,696 and a significance value of 0,010. The constribution of inventory turnover and receivable as a whole to liquidity is 34,9% while the remaining 65,1% is influenced by other factors not discused in this study.
KOSMOLOGI DALAM EKSPRESI RITUS SIKLUS HIDUP MUSLIM JAWA BARAT
Authors: Nulhasanah Lisan , Hasan Hidayat , Hidayat Asep Ahmad , Supendi Usman , Tohir Ajid 
Published: September 2023

The research aims to understand cosmological relationships both in the context of space and time, such as apamali or taboos in the life cycle which includes cultural customs, rituals: birth, circumcision and marriage in the West Javanese Sundanese community, both in the northern coastal communities (Cirebonan) and inlad. (mountains) like in Tatar Priangan (West Java settlement). The research methode used in thiss research in an antrhropological research method woth alibrary study approach with a content analysis method (Symbolic interpretation) of data from the anthropological method. The research resultas show that the life cycle of the people of West Java both in Sunda-Priangan and Cirebon, which represents the people of the North Coast of Java (West), implies the existence of four importans stages, namely pregnancy, birth, circumcision and marriage. Each of these stages has an important symbolic meaning in building identity and social ralations in West Java society which contains the meaning of the slametan cultural tradition in these cycles related to the subtsnce of belief or religion (Islam). Keywords: Cosmology; Pregnancy; Birth; Circumcision; Marriage
PENGARUH STORE ATMOSPHERE DAN VARIASI PRODUK TERHADAP KEPUASAN KONSUMEN DI TOKO TEKSTIL MULIA TEX BEUREUNUEN KABUPATEN PIDIE
Authors: Sapitri Adinda , Zulkifli Zulkifli , Yusnidar Cut 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui “Pengaruh Store Atmosphere dan Variasi Produk terhadap Kepuasan Konsumen di Toko Tekstil Mulya Tex Beureunuen Kabupaten Pidie”. Dimana variabel independen yaitu Store Atmosphere (X1) dan Variasi Produk (X2), dan Kepuasan Konsumen (Y) sebagai variabel dependennya. Populasi dalam penelitian ini adalah konsumen yang membeli pada Pelanggan Toko Tekstil Mulya Tex Beureunuen Kabupaten Pidie. Kemudian digunakan metode Simple Random Sampling, yaitu pengambilan sampel anggota populasi dilakukan secara acak tanpa memperhatikan strata yang ada dalam populasi itu. Sampel dalam penilitian ini adalah 100 responden. Data dikumpulkan dengan menggunakan metode survey melalui kuesioner yang diisi oleh responden. Kemudian data yang diperoleh dianalisis dengan menggunakan analisis regresi berganda. Analisis ini meliputi Uji Validitas, Uji Reliabilitas, Analisis Regresi berganda Uji Asumsi Klasik, Uji Hipotesis melalui Uji f dan Uji t, serta analisis Koefisien Determinasi (R²). Berdasarkan hasil penelitian, diperoleh persamaan regresi: Y = 10,473 + 0,329 X1 + 0,264 X2 . Berdasarkan hasil analisis di atas dapat disimpulkan bahwa dari ketiga variabel yang diteliti, ternyata variabel Store Atmosphere (X1), mempunyai pengaruh yang paling dominan sebesar 32.9% terhadap Kepuasan Konsumen (Y) di Toko Tekstil Mulya Tex Beureunuen Kabupaten Pidie. Pengaruh antara variabel dependen dan independen yaitu masing-masing variabel Store Atmosphere (X1) dan Variasi Produk (X2), terhadap Kepuasan Konsumen (Y) di Toko Tekstil Mulya Tex Beureunuen Kabupaten Pidie dengan indeks korelasi sebesar 46,3% Ini berarti hubungan tersebut sangat kuat. Kemudian indeks determinasi masing-masing Store Atmosphere (X1) dan Variasi Produk (X2) sebesar 0,214 atau 21,4%, ini berarti berpengaruh secara signifikan terhadap Kepuasan Konsumen (Y) di Toko Tekstil Mulya Tex Beureunuen Kabupaten Pidie yaitu sebesar 78,6% yang dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini. Kata kunci : Store Atmosphere, Variasi Produk dan Kepuasan Konsumen.
PENGARUH PERILAKU ORGANISASI DAN KEPUASAN KERJA TERHADAP EFESIENSI PELAYANAN PUBLIK PADA DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN PIDIE
Authors: Nita Agus , Abdullah Husaini , Umar Nyak 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui “Pengaruh Perilaku organisasi dan Kepuasan kerja Terhadap Efesiensi pelayanan publik Pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pidie”. Dimana variabel independen yaitu Perilaku organisasi (X1) dan Kepuasan kerja (X2), dan Efesiensi pelayanan publik (Y) sebagai variabel dependennya. Pegawai yang bekerja pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pidie baik pegawai tetap maupun pegawai kontrak yang mana jumlahnya 72 Pegawai. Seluruh populasi dalam penelitian ini diambil sebagai Sampel dengan menggunakan teknik Convinience Sampling. Data dikumpulkan dengan menggunakan metode survey melalui kuesioner yang diisi oleh responden. Kemudian data yang diperoleh dianalisis dengan menggunakan analisis regresi berganda. Analisis ini meliputi Uji Validitas, Uji Reliabilitas, Analisis Regresi berganda Uji Asumsi Klasik, Uji Hipotesis melalui Uji F dan Uji t, serta analisis Koefisien Determinasi (R²). Y = 3.111 + 0.489 X1+ 0.394 X2. Hubungan antara variabel dependen dan independen yaitu masing-masing variabel perilaku organisasi (X1), Kepuasan kerja (X2) terhadap efesiensi pelayanan publik pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pidie dengan indeks korelasi sebesar 84.4% Ini berarti hubungan tersebut sangat kuat. Kemudian indeks determinasi masing-masing variabel perilaku organisasi (X1), kepuasan kerja (X2) sebesar 71.32%, ini berarti kedua variabel berpengaruh secara signifikan terhadap efesiensi pelayanan publik pada Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pidie, dan sebesar 28.7% yang dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini. Kata kunci : Perilaku organisasi, Kepuasan kerja, Efesiensi pelayanan publik
Pengaruh Kompetensi Auditor, Workload, dan Time Budget Pressure, Terhadap Kualitas Audit Dengan Etika Audit Sebagai Variabel Pemoderasi
Authors: Rizky Muhammad Alfa , Dwi Astuti Christina 
Published: September 2023

Tujuan dari penelitian ini adalah menemukan informasi dari kompetensi Auditor, workload, dan time budget pressure, apakah bisa mempengaruhi terhadap kualitas audit yang mana disertai dengan variabel pemoderasi yaitu etika audit. Jenis dan metode dalam observasi ini yaitu kuantitatif dan kuesioner yang mana populasi dalam observasi ini yaitu auditor yang tentunya masih bekerja di Kantor Akuntan Publik di Jakarta. Dalam memilih sampel yang akan diambil pada observasi ini tentunya menggunakan purposive dan snowball sampling dimana sampling yang didapatkan berjumlah 216 responden. Kesimpulannya hasil yang didapatkan dalam observasi ini yaitu kompetensi auditor berpengaruh positif terhadap kualitas audit. Sementara time budget pressure terbukti berpengaruh negative, workload tidak berpengaruh negatif terhadap kualitas audit. Selain itu, etika audit tidak mampu memperkuat pengaruh kompetensi auditor terhadap kualitas audit dan etika audit tidak mampu memperlemah pengaruh dari workload, time budget pressure terhadap kualitas audit.
Record Management Practices and the Performance of Produce Dealers in Lira City
Authors: Odongo Douglas Daniel , Mwesigwa David 
Published: September 2023

Purpose: The study aimed to determine the effect of record management practices on the performance of produce dealers in lira city, Uganda. Specifically, the examined record filling, record retention and record retrieval on performance of produce dealers.
Methodology: The study adopted a cross-sectional study design, which employed a mixed methods approach of both quantitative and qualitative methods. The study population consisted of 195 respondents, which comprised of produce dealers in Lira City. Both the Simple random sampling technique and purposive sampling technique were used to select a sample of 103 participants. The researcher adopted Self-Administered Questionnaires to collect quantitative data and an interview guide to collect qualitative data. Both descriptive statistics (mean, and standard deviation), and inferential statistics (correlation and regression) were used to analyse numerical data. Content analysis was used to analyse qualitative data.
Findings: The findings revealed a statistically significant positive relationship between record filling, record retrieval and performance while insignificant relationship was realised between record retention and performance. Further, it was revealed that record filling and record retrieval yields a significant effect on performance while record retention yields insignificant effect on performance.
Unique contribution to theory, policy and practice: The study concluded that record management significantly affects performance of produce dealers in Lira City. It is encouraged that, for good performance of produce dealers, the authorities of Lira City should enhance that capacity of business people in record management by training them in record management. This study is very instrumental in unveiling the pertaining issues in the field of produce dealers, which has become a very lucrative business in Uganda in terms of how record keeping is a central aspect in their day-to-day operations.