bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model misspecification and robust analysis for outcome‐dependent sampling designs under generalized linear models
Authors: Maronge Jacob M. , Schildcrout Jonathan S. , Rathouz Paul J. 
Published: February 2023

Outcome‐dependent sampling (ODS) is a commonly used class of sampling designs to increase estimation efficiency in settings where response information (and possibly adjuster covariates) is available, but the exposure is expensive and/or cumbersome to collect. We focus on ODS within the context of a two‐phase study, where in Phase One the response and adjuster covariate information is collected on a large cohort that is representative of the target population, but the expensive exposure variable is not yet measured. In Phase Two, using response information from Phase One, we selectively oversample a subset of informative subjects in whom we collect expensive exposure information. Importantly, the Phase Two sample is no longer representative, and we must use ascertainment‐correcting analysis procedures for valid inferences. In this paper, we focus on likelihood‐based analysis procedures, particularly a conditional‐likelihood approach and a full‐likelihood approach. Whereas the full‐likelihood retains incomplete Phase One data for subjects not selected into Phase Two, the conditional‐likelihood explicitly conditions on Phase Two sample selection (ie, it is a “complete case” analysis procedure). These designs and analysis procedures are typically implemented assuming a known, parametric model for the response distribution. However, in this paper, we approach analyses implementing a novel semi‐parametric extension to generalized linear models (SPGLM) to develop likelihood‐based procedures with improved robustness to misspecification of distributional assumptions. We specifically focus on the common setting where standard GLM distributional assumptions are not satisfied (eg, misspecified mean/variance relationship). We aim to provide practical design guidance and flexible tools for practitioners in these settings.
The Effect of Hydrophobically Modified Iron Catalysts with Hexadecyltrimethoxysilane on Fischer‐Tropsch Synthesis
Authors: Chen Zhiping , Meng Yongle , Lu Jing , Zhou Wenwu , Yang Zhiyuan , Zhou Anning 
Published: February 2023

AbstractHydrophobic modification of Fischer‐Tropsch synthesis catalyst can inhibits water gas shift(WGS) reaction and regulates product distribution. Herein, a series of hydrophobic Fe2O3@SiO2‐xHDTMS (Hexadecyltrimethoxysilane, HDTMS. x represents the amount of HDTMS.) catalysts with various HDTMS content were synthesized for Fischer‐Tropsch synthesis to light hydrocarbons. The Fe2O3@SiO2‐xHDTMS catalysts were characterized by X‐ray diffractometer(XRD), scanning electron microscope(SEM), transmission electron microscope(TEM), fourier transform infrared spectrometer(FT‐IR) and contact angle measuring instrument(CAMI). After HDTMS modification, the hydrophobicity of the catalyst is significantly improved, the selectivity of the catalyst to CO2is significantly reduced due to the inhibition of WGS reaction, and the selectivity of hydrocarbon products is significantly improved. This indicates that HDTMS is very suitable as a silanizer for hydrophobic modification of Fischer‐Tropsch synthesis catalysts. With the increase of HDTMS content, the hydrophobicity of the catalyst always increased, but the selectivity of CO2in Fischer‐Tropsch synthesis products decreased first and then increased, and the selectivity of hydrocarbons increased first and then decreased, indicating that the content of HDTMS has a significant impact on the hydrophobicity and catalytic performance of the catalyst.
Oligomeric Heterogeneous Double Metal Cyanide Catalyst for One‐pot Ring‐Opening Polymerization
Authors: Verma Akash , Sharma Bhawna , Saini Swati , Behera Babita , Saran Sandeep , Ganguly Sudip K. , Kumar Umesh 
Published: February 2023

AbstractA series of efficient oligomeric zinc and cobalt‐based double metal cyanide (DMC) catalysts was prepared using Ethylenediaminetetracetic acid (EDTA) as an organic complexing agent (CA) and tested for ring‐opening polymerization (ROP) of propylene oxide (PO) to synthesize polyether polyols (PPG). The complex formation of EDTA with Zn and cyanide (CN−) with Zn surface and morphology of the DMC catalyst were confirmed by PXRD, FTIR, SEM, and UV‐Vis. Furthermore, the13C‐CP MAS spectroscopy showed an integral ratio of 3.2 : 1 for the bound and free carboxyl group of EDTA in the catalyst, respectively. The maximum yield (>98 %) of PPG with turnover frequency (TOF) of 9625 h−1was obtained with controlled PDI (1.1) in only 1 h with 1330 g mol−1Mw, 0.009 meq g−1unsaturation number, and 8.1 mg‐KOH g−1OH value at optimized reaction condition (Catalyst amount=0.015 g, Time=1 h, Temperature=105 °C, Pressure=5 bar, PO : PEG‐600=40 : 1). The ROP showed first‐order kinetics behavior by1H NMR spectroscopy with proposed coordination mechanism.
Boosting Li–O2 Battery Performance via Coupling of P–N Site‐Rich N, P Co‐Doped Graphene‐Like Carbon Nanosheets with Nano‐CePO4
Authors: Wu Di , Wu Shan , Zhang Genlei , Hui Chenyang , Cao Dongjie , Guo Shiyu , Feng Huajie , Wang Qi , Cheng Sheng , Cui Peng , Yang Zhenzhen 
Published: February 2023

AbstractDevelopment of efficient and robust cathode catalysts is critical for the commercialization of Li‐O2 batteries (LOBs). Herein, a well‐designed CePO4@N‐P‐CNSs cathode catalyst for LOBs via coupling P‐N site‐rich N, P co‐doped graphene‐like carbon nanosheets (N‐P‐CNSs) with nano‐CePO4 via a novel “in situ derivation” coupling strategy by in situ transforming the P atoms of P‐C sites in N‐P‐CNSs to CePO4 is reported. The CePO4@N‐P‐CNSs exhibit superior bifunctional ORR/OER activity relative to commercial Pt/C‐RuO2 with an overall overpotential of 0.64 V (vs RHE). Moreover, the LOB with CePO4@N‐P‐CNSs as the cathode catalyst delivers a low charge overpotential of 0.67 V (vs Li/Li+), high discharge capacity of 29774 mAh g−1 at 100 mA g−1 and long cycling stability of 415 cycles, respectively. The remarkably enhanced LOB performance is attributable to the in situ derived CePO4 nanoparticles and the P‐N sites in N‐P‐CNSs, which facilitate increased bifunctional ORR/OER activity, promote the rapid and effective decomposition of Li2O2 and inhibit the formation of Li2CO3. This work may provide new inspiration for designing efficient, durable, and cost‐effective cathode catalysts for LOBs.
Gram‐Scale Room‐Temperature Synthesis of Solid‐State Fluorescent Carbon Nanodots for Bright Electroluminescent Light Emitting Diodes
Authors: Zheng Mengyun , Jia Haoran , Zhao Biao , Zhang Chengyang , Dang Qi , Ma Huanyu , Xu Kunxiang , Tan Zhan'ao 
Published: February 2023

AbstractThe reaction conditions of high temperature and high pressure will introduce structural defects, high energy consumption, and security risks, severely hindering the industrial application of organic carbon nanodots (CDs). Moreover, the aggregation caused quenching effect also fundamentally limits the CDs based electroluminescent light emitting diodes (LEDs). Herein, for the first time, a rapid one‐step room temperature synthetic strategy is introduced to prepare highly emissive solid‐state‐fluorescent CDs (RT‐CDs). A strong oxidizing agent, potassium periodate (KIO4), is adopted as a catalyst to facilitate the cyclization of o‐phenylenediamine and 4‐dimethylamino phenol in aqueous solution at room temperature for only 5 min. The resultant organic molecule, 2‐(dimethylamino) phenazine, will self‐assemble kinetically to generate supramolecular‐structure CDs during crystallization. The elaborately arranged supramolecular structure (J aggregates) endows CDs with intense solid‐state‐fluorescence. Density functional theory (DFT) calculation shows that the excited state of RT‐CDs exhibits charge transfer characteristic owing to the unique donor‐Π‐acceptor structure. A high‐performance monochrome RT‐CDs based electroluminescent LEDs (2967 cd m−2 and 1.38 cd A−1) were fabricated via systematic optimizations of device engineering. This work provides a concrete and feasible avenue for the rapid and massive preparation of CDs, advancing the commercialization of CDs based optoelectronic devices.
Rosmarinic Acid‐Crosslinked Supramolecular Nanoassembly with Self‐Regulated Photodynamic and Anti‐Metastasis Properties for Synergistic Photoimmunotherapy
Authors: Zhou Yang , Zhang Yiwei , Jiang Chaoqing , Chen Yuxiu , Tong Fan , Yang Xiaotong , Wang Yazhen , Xia Xue , Gao Huile 
Published: February 2023

AbstractA primary concern about photodynamic therapy (PDT) is its inability to regulate the generation levels of reactive oxidative species (ROS) based on the complex microenvironment, resulting in the impairment toward normal tissues and immunosuppression. Besides, tumor metastasis also compromises PDT's efficacy and drives mortality. However, it is very challenging to achieve such two goals within one nanosystem. Here, the nanoassembly (CPR) with self‐regulated photodynamic and antimetastasis properties comprises three parts: chlorin e6‐conjugated β‐cyclodextrin (CD‐Ce6) acts as the main PDT agent and ferrocene (Fc)‐terminated phenylboronic acid‐containing conjugates entering into the cavity of CD‐Ce6, as well as rosmarinic acid (RA)–boronic acid crosslinked shell. Compared with non‐crosslinked counterpart, CPR displays better stability and enhanced tumor accumulation. Under laser irradiation, CPR generates plenty of ROS to damage tumor cells and induce immunogenic cell death. Mildly acidic TME partly cleaves the crosslinkers to dissociate antioxidant RAs from micelles, which together with Fc in CPR scavenge PDT‐induced ROS in the TME. By contrast, under acidic lysosomal conditions, Fc catalyzes abundant H2O2 in tumor cells to produce highly cytotoxic •OH, while RA continuously reduces ferroptosis‐generated Fc+ into Fc, both to augment the PDT efficacy in tumor cells. CPR also remarkably hinders the epithelial‐mesenchymal transition to prevent the lung metastasis.
A validated stability‐indicating reversed‐phase liquid chromatography method for the quantification of Ixabepilone (Oncology drug) in the parenteral dosage form
Authors: Nekkalapudi Arjuna Rao , Srinivasu Navuluri , Pippalla Sreenivas , Katari Naresh Kumar , Kumar Cholleti Vijay , Gumudavelli Sridhar 
Published: February 2023

AbstractA quick and simple isocratic stability indicating method has been developed for the quantification of Ixabepilone in active pharmaceutical ingredient and injection dose formulation using reversed phase‐high‐performance liquid chromatography. Based on the response of Ixabepilone and impurities, the method was developed on a Symmetry C18 (150 × 4.6) mm, 5‐micron (Waters) column. An isocratic mobile phase consisted of pH 4.7 acetate buffer (10 mM) and acetonitrile in the composition of 60:40 v/v at 1.0 ml/min flow rate with a run time of 15 min, and Ixabepilone was eluted at about retention time of 5.1 min. The developed method is validated to meet International Conference on Harmonization standards. Linearity of Ixabepilone was established for the concentration range 0.050 to 0.15 mg/ml (r2 > 0.999) with respect to working concentration 0.10 mg/ml. Recovery was established from 50% (0.050 mg/ml) to 150% (0.15 mg/ml) of the target concertation (0.10 mg/ml). Precision and Intermediate precision met the acceptance criteria as per International Conference on Harmonization Q2(R1). It was proved that the stability indicating nature for quantifying Ixabepilone in Ixabepilone active pharmaceutical ingredient and drug product. As a result, the assay of Ixabepilone can be analyzed using this method for pharmaceutical development and quality control.
Listening session with the US Food and Drug Administration, Lewy Body Dementia Association, and an expert panel
Authors: Sabbagh Marwan N. , Taylor Angela , Galasko Douglas , Galvin James E. , Goldman Jennifer G. , Leverenz James B. , Poston Kathleen L. , Boeve Bradley F. , Irwin David J. , Quinn Joseph F. 
Published: February 2023

AbstractThe regulatory path for drug approval is increasingly well defined. Drugs for the treatment of Alzheimer disease (AD) need to show statistically significant benefit over placebo with respect to cognitive and functional measures, with the Clinical Dementia Rating scale and Alzheimer's Disease Assessment Scale–Cognitive Subscale being among the most often used instruments in AD clinical trials. In contrast, there are no validated instruments for use in clinical trials of drugs for the treatment of dementia with Lewy bodies. This poses challenges for drug development because the regulatory pathway to drug approval requires demonstrable efficacy measures. In December 2021, the Lewy Body Dementia Association advisory group met with representatives from the US Food and Drug Administration to discuss the lack of approved drugs and treatments, discernment of efficacy measures, and identification of biomarkers.Highlights
The Lewy Body with Dementia Association convened a listening session with the US Food and Drug Administration on dementia with Lewy bodies (DLB) and clinical trial design.
Gaps include DLB‐specific measures, alpha synuclein biomarkers, and coexisting pathologies.
DLB clinical trial design should focus on clinical value and disease specificity.
Using Superhero Graphic Novels to Foreground Transitions in Our Teaching with Upper Elementary and Middle‐Grade Readers
Authors: Rodríguez‐Astacio René M. , Low David E. 
Published: February 2023

AbstractThis column will focus on several standalone titles offered by Marvel/Graphix and DC Kids/YA and their pedagogical potential for exploring transitions with upper elementary and middle grades readers. Because children's lives are inherently in flux, they should have opportunities to read and discuss empowering stories, in a format and featuring characters they enjoy, that are attuned to the various types of transition they experience and encounter.
Evaluation of heart fatty acid‐binding protein as a biomarker for canine leishmaniosis
Authors: Casamián‐Sorrosal Domingo , Barrera‐Chacón Rafael , Fonfara Sonja , Cristobal‐Verdejo José Ignacio , Talavera‐López Jesús , Belinchón‐Lorenzo Silvia , Miró‐Corrales Guadalupe , Caro‐Vadillo Alicia , Duque Francisco Javier 
Published: February 2023

AbstractBackgroundMyocarditis frequently occurs in canine leishmaniosis (CanL). Heart fatty acid‐binding protein (HFABP) is a biomarker of myocardial damage.MethodsThis study aimed to compare HFABP concentration (HFABPc) in healthy dogs and dogs at different stages of CanL and evaluate the correlation of this biomarker with several clinicopathological and echocardiographic variables. Thirty‐one dogs diagnosed with CanL and 10 healthy dogs were included.ResultsHFABPc was not statistically different (p > 0.05) between groups of dogs at different LeishVet stages of CanL or between groups with high versus low to intermediate serology titres. In 70% of CanL dogs, HFABPc was within the 95% confidence interval limits of the mean of healthy dogs. A moderate negative correlation with globulin (r = −0.519; p = 0.03) and haematocrit (HCT) (r = −0.538; p = 0.02) was observed. No other significant correlation (p > 0.05) was observed with any other variable.LimitationsMany statistical tests were performed, and therefore, type I error cannot be ruled out.ConclusionHFABPc is not consistently elevated in dogs with CanL and is not associated with the severity of the disease, or most echocardiographic or clinicopathological variables studied. The correlation with globulin and HCT was not strong and not considered clinically significant. HFABPc lacks sufficient predictive capacity in dogs with CanL, discouraging further research or clinical use of this biomarker in this disease.
People need freshwater biodiversity
Authors: Lynch Abigail J. , Cooke Steven J. , Arthington Angela H. , Baigun Claudio , Bossenbroek Lisa , Dickens Chris , Harrison Ian , Kimirei Ismael , Langhans Simone D. , Murchie Karen J. , Olden Julian D. , Ormerod Steve J. , Owuor Margaret , Raghavan Rajeev , Samways Michael J. , Schinegger Rafaela , Sharma Subodh , Tachamo‐Shah Ram‐Devi , Tickner David , Tweddle Denis , Young Nathan , Jähnig Sonja C. 
Published: February 2023

AbstractFreshwater biodiversity, from fish to frogs and microbes to macrophytes, provides a vast array of services to people. Mounting concerns focus on the accelerating pace of biodiversity loss and declining ecological function within freshwater ecosystems that continue to threaten these natural benefits. Here, we catalog nine fundamental ecosystem services that the biotic components of indigenous freshwater biodiversity provide to people, organized into three categories: material (food; health and genetic resources; material goods), non‐material (culture; education and science; recreation), and regulating (catchment integrity; climate regulation; water purification and nutrient cycling). If freshwater biodiversity is protected, conserved, and restored in an integrated manner, as well as more broadly appreciated by humanity, it will continue to contribute to human well‐being and our sustainable future via this wide range of services and associated nature‐based solutions to our sustainable future.This article is categorized under:Human Water > Value of WaterWater and Life > Nature of Freshwater EcosystemsScience of Water > Water and Environmental Change
A promising intersection of excited‐state‐specific methods from quantum chemistry and quantum Monte Carlo
Authors: Otis Leon , Neuscamman Eric 
Published: February 2023

AbstractWe present a discussion of recent progress in excited‐state‐specific quantum chemistry and quantum Monte Carlo alongside a demonstration of how a combination of methods from these two fields can offer reliably accurate excited state predictions across singly excited, doubly excited, and charge transfer states. Both of these fields have seen important advances supporting excited state simulation in recent years, including the introduction of more effective excited‐state‐specific optimization methods, improved handling of complicated wave function forms, and ways of explicitly balancing the quality of wave functions for ground and excited states. To emphasize the promise that exists at this intersection, we provide demonstrations using a combination of excited‐state‐specific complete active space self‐consistent field theory, selected configuration interaction, and state‐specific variance minimization. These demonstrations show that combining excited‐state‐specific quantum chemistry and variational Monte Carlo can be more reliably accurate than either equation of motion coupled cluster theory or multi‐reference perturbation theory, and that it can offer new clarity in cases where existing high‐level methods do not agree.This article is categorized under:
Electronic Structure Theory > Ab Initio Electronic Structure Methods
Software > Quantum Chemistry
The Pol III transcriptome: Basic features, recurrent patterns, and emerging roles in cancer
Authors: Zhou Sihang , Van Bortle Kevin 
Published: February 2023

AbstractThe RNA polymerase III (Pol III) transcriptome is universally comprised of short, highly structured noncoding RNA (ncRNA). Through RNA–protein interactions, the Pol III transcriptome actuates functional activities ranging from nuclear gene regulation (7SK), splicing (U6, U6atac), and RNA maturation and stability (RMRP, RPPH1, Y RNA), to cytoplasmic protein targeting (7SL) and translation (tRNA, 5S rRNA). In higher eukaryotes, the Pol III transcriptome has expanded to include additional, recently evolved ncRNA species that effectively broaden the footprint of Pol III transcription to additional cellular activities. Newly evolved ncRNAs function as riboregulators of autophagy (vault), immune signaling cascades (nc886), and translation (Alu, BC200, snaR). Notably, upregulation of Pol III transcription is frequently observed in cancer, and multiple ncRNA species are linked to both cancer progression and poor survival outcomes among cancer patients. In this review, we outline the basic features and functions of the Pol III transcriptome, and the evidence for dysregulation and dysfunction for each ncRNA in cancer. When taken together, recurrent patterns emerge, ranging from shared functional motifs that include molecular scaffolding and protein sequestration, overlapping protein interactions, and immunostimulatory activities, to the biogenesis of analogous small RNA fragments and noncanonical miRNAs, augmenting the function of the Pol III transcriptome and further broadening its role in cancer.This article is categorized under:
RNA in Disease and Development > RNA in Disease
RNA Processing > Processing of Small RNAs
RNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications
Effect of imperfect interface on the effective properties of elastic micropolar multilaminated nanostructures
Authors: Espinosa‐Almeyda Yoanh , Yanes Victor , Rodríguez‐Ramos Reinaldo , Otero José A. , Sánchez‐Valdés César F. , Camacho‐Montes Héctor , Longoria Pablo Padilla , Sabina Federico J. 
Published: February 2023

AbstractIn this paper, the problem of a heterogeneous elastic micropolar nanostructure with a periodic structure subject to imperfect contact conditions is analyzed through the two‐scale asymptotic homogenization method (AHM). The imperfect interface is modeled as a generalization of the well‐known spring model; that is, the homogeneous imperfect interface is described by the following conditions: tractions and coupled stress are continuous, but displacements and microrotations are discontinuous across the imperfect interface. The jumps in displacements and microrotations are proportional to the interface traction and coupled stress components, respectively. In particular, micropolar multilaminated nanocomposites with centro‐symmetric isotropic constituents and imperfect contact conditions are studied. From AHM, the solutions for the displacement and microrotation fields are found by means of two‐scale series expansions depending on a local (microscopic) variable and a global (macroscopic) variable. The local problem statements and the corresponding effective properties are explicitly described. The formulation depends on the constituent physical properties, the imperfection parameters, the cell length in the y3‐direction, and the phase's volume fractions. Numerical results are illustrated and discussed. We concluded that the effective moduli are affected by the imperfections and the cell length in the y3‐direction.
Lessons Learned from Refugee Camps: From Fetishizing Design to Researching, Drawing, and Co-Producing
Authors: Dalal Ayham 
Published: February 2023

AbstractThis chapter explores cases when a design-oriented approach can be harmful, especially if it shifts the attention from refugees’ needs and complex realities toward producing “successful” and “innovative” solutions as determined by the expectations of the field of architecture. To illustrate this point, the author discusses examples from workshops and seminars tackling urban and spatial issues regarding refugees. As a successful model and counterpoint, the chapter demonstrates how a successful process includes the active involvement of refugees and a collaborative approach toward fulfilling their needs. Additionally, the chapter illustrates how a research-oriented approach to architectural design can powerfully raise awareness about the complex spatial realities that refugees face in exile, citing examples from studios and design workshops conducted in refugee camps in Jordan and Berlin. Finally, the chapter underscores the last point, by giving further examples from a seminar taught to students in the Urban Studies program at Vassar College.