bluuebunny/crossref_metadata_2025_split huggingface dataset:
Washout appearance of hepatocellular carcinomas using standardized contrast-enhanced ultrasound (CEUS) including an extended late phase observation – Real-world data from the prospective multicentre DEGUM study
Authors: Meitner-Schellhaas Barbara , Jesper Daniel , Goertz Rüdiger Stephan , Zundler Sebastian , Strobel Deike 
Published: June 2023

BACKGROUND: Non-invasive diagnosis of hepatocellular carcinoma (HCC) in contrast-enhanced ultrasound (CEUS) is based on the combination of arterial phase hyperenhancement (APHE) and subsequent late (>60 seconds) and mild contrast washout (WO). Whereas APHE is seen in the majority of HCC, wash-out pattern may vary in onset and intensity. In some HCC lesions, even no washout is seen at all. OBJECTIVE: Our prospective multicentre DEGUM HCC CEUS study aimed at identifying typical and atypical washout appearance of HCC in a real-life setting. METHODS: High-risked patients for HCC with focal liver lesions upon B-mode ultrasound were recruited prospectively. In a multicentre real-life setting, a standardised CEUS examination including an extended late phase up to 6 minutes was performed. CEUS patterns of HCC were recorded, and onset and intensity of washout appearance were assessed with respect to patient and tumour characteristics. Histological findings served as reference standard. RESULTS: In 230/316 HCC (72.8%), a CEUS pattern of APHE followed by WO was observed. In 158 cases (68.7%), WO was typical (onset > 60 seconds, mild intensity). 72 cases (31.3%) showed marked and / or early WO, whereas in 41 HCCs (13%), APHE was followed by sustained isoenhancement. Atypical WO upon CEUS was associated with macroinvasion of the liver vessels, portal vein thrombosis and diffuse growth pattern, but not tumour size and histological grading. CONCLUSIONS: In a prospective multicentre real-life setting, APHE is followed by atypical washout appearance or no washout at all in almost half of the HCCs with APHE. The examiner has to bear in mind that in spite of a characteristic APHE in HCCs, washout appearance can be atypical in CEUS, especially in HCCs with macrovascular invasion or diffuse growth pattern.
Long period changes of hippocampal cerebral blood flow and its correlation with anxiety-like behavior and inflammation after incomplete cerebral ischemia reperfusion in rats
Authors: Fu Lan , Guan Lin-Na 
Published: June 2023

OBJECTIVE: This study was designed to summarize the changes of cerebral blood flow (CBF) in the bilateral hippocampal CA1 region of the hemorrhagic shock reperfusion (HSR) model of rats and their correlation with anxiety-like behavior and inflammation. METHODS: Rats were randomly divided into the HSR group and the Sham group. 30 rats in each group were subdivided into 5 time points (1 w, 2 w, 4 w, 8 w, and 12 w) for examination. 3D-arterial spin labeling (3D-ASL) was performed. Long period anxiety-like behaviors were analyzed through the open field test. Histopathology was used to detect astrocytic activation in bilateral hippocampus. The concentrations of pro-inflammatory cytokines were analyzed by ELISA. RESULTS: At 1, 2, 4, and 8 weeks, CBF in bilateral hippocampus CA1 area of the rats in the Sham group was significantly higher than the rats in the HSR group. The rats in the HSR group had significantly shorter total traveled distance, lower velocity, and less rearing counts than those in the Sham group at 1, 2, 4, 8, and 12 weeks after the surgery. The CBF at 1, 2, 4, 8, and 12 weeks after the surgery had positive correlation with the total traveled distance, velocity, and rearing counts in the open field test. The rats in the HSR group had significantly higher GFAP intensity and the concentrations of IL-6, IL-1β, and TNF-α than those in the Sham group at 1, 2, 4, 8, and 12 weeks after the surgery. The CBF at 1, 2, 4, 8 and 12 weeks after the surgery had significantly negative correlation with the GFAP intensity and the concentrations of IL-6, IL-1β, and TNF-α. CONCLUSION: In conclusion, CBF in bilateral hippocampus CA1 area, spatial exploration ability in rats with HSR were decreased while the astrocyte activation was enhanced. During the long period after the induction of HSR, the value of CBF in bilateral hippocampus CA1 area was proved to have significant correlation with anxiety-like behaviors and astrocyte activation.
Isometric hip abduction and adduction strength ratios: A literature review with quantitative synthesis
Authors: Marušič Jan , Kozinc Žiga , Hadžić Vedran , Šarabon Nejc 
Published: June 2023

BACKGROUND: Measurements of hip abduction (ABD) and adduction (ADD) are important in strength and conditioning as well as in clinical practice. However, there is no clear consensus on how ABD and ADD compare in strength in different populations. OBJECTIVE: The aim was to perform a quantitative synthesis of comparisons between the isometric strength of ABD and ADD in different populations. METHODS: ABD and ADD strength data were collected and pooled mean values for ABD:ADD strength ratio were calculated and expressed as standardized mean differences. Forty studies of healthy adults, 5 studies of healthy older adults and 14 studies of adults with various musculoskeletal injuries were included in the analysis. RESULTS: Healthy (non-athletic) males, healthy older adults, and adults with hip and groin pathologies or osteoarthritis tend to have the same ADD and ABD strength; male athletes tend to have a stronger ADD compared with ABD; healthy females and adults with patellofemoral pain tend to have a stronger ABD compared with ADD. CONCLUSIONS: These results can serve as a database to help compare and interpret measurements of ADD and ABD strength ratio in different populations.
Influence of growing environment and pruning techniques on storage and quality traits of Vaccinium corymbosum L., cv ‘Duke’
Authors: Varaldo Alice , Chiabrando Valentina , Giacalone Giovanna 
Published: June 2023

BACKGROUND: Due to the increasing market demand for blueberries, the amount of land dedicated to their production is expanding. Therefore, cultivation techniques to ensure high quality and a longer shelf life have become key concerns for the blueberry industry and consumers. OBJECTIVE: This study investigated the impact of various growing environments and pruning techniques on the quality and shelf life of highbush blueberry ( Vaccinium corymbosum L. cv. ‘Duke’) during cold storage. METHODS: In this study, six commercial orchards were selected based on the type of pruning (light or hard) and the plot’s altitude (lowland, hill, or mountain). After harvest, the blueberries were stored at 1°C and 90% RH for 21 days. Quality analyses were performed on days 0, 10, and 21 of storage. The data were processed with a factor-designed analysis of variance (one-way ANOVA). RESULTS: Blueberries from the lowland cultivation area with light pruning had a longer shelf life. At harvest, the lowland area had indeed produced firmer blueberries that were sweeter and less acidic, and cold storage positively preserved these characteristics compared to fruit grown at other altitudes. CONCLUSIONS: In summation, the lowland area produced firmer berries that retained their characteristics after 10 days of storage, especially those harvested from hard-pruned plants. Notably, the bioactive compounds were not affected by the pruning method. However, when combined with 10 days of storage, light pruning was associated with better preservation of the total phenol content.
Comparative characterization and expression analysis revealed cinnamyl alcohol dehydrogenase genes differentially responding to Colletotrichum fructicola in woodland and cultivated strawberries
Authors: Li Zi-Yi , Duan Ke , Zhu Jia-Jun , Bin Ling , Wang Xin-Yi , Chen Si-Yu , Li Xue , Geng Chun-Nu , Gao Qing-Hua 
Published: June 2023

BACKGROUND: Strawberry ( Fragaria× ananassa) production is hampered by anthracnose caused by Colletotrichum spp. Cinnamyl alcohol dehydrogenase (CAD) catalyzes lignin biosynthesis to fortify plant cell wall upon various stresses, but their involvement in strawberry resistance is elusive. OBJECTIVE: Current work aims to uncover the involvement of CAD genes in both woodland and cultivated strawberry responses to Colletotrichum spp. METHODS: Genome-wide identification of CAD genes was updated in cultivated strawberry. Comparative molecular characterization integrated with pathogenesis phenotyping after C. fructicola inoculation, were followed by RT-qPCR analysis and RNAseq data retrieval. RESULTS: Cultivated strawberry comprises 32 CAD genes of three classes. Thirteen syntenic relationships were observed between cultivated and woodland strawberry, with high homology in protein coding regions while promoters being greatly diversified. F. vesca ‘Hawaii4’ was least susceptible, followed by octoploid cultivar ‘ShenQi’, and ‘Benihoppe’ the most susceptible to C. fructicola. The class I CAD4 and CAD5, preferentially expressed in leaves and crowns, respectively, were up-regulated in susceptible varieties at 72 h post inoculation (hpi). Of class II, CAD8 was up-regulated in three genotypes at distinct timepoints, while CAD12 was quickly down-regulated in ‘ShenQi’ upon inoculation. CAD1 and CAD2 of class III were down-regulated in ‘ShenQi’ and ‘Hawaii4’ at distinct stages. The strong involvement of CAD genes in strawberry response to Colletotrichum spp. sets a basis for future functional study. CONCLUSION: F. vesca is less susceptible to Colletotrichum spp. than cultivated strawberries but the expression of CAD family in F. vesca and F.× ananassa were differentially provoked in timing and magnitude hinting no correlation with strawberry resistance to this pathogen.
Physical Exercise as a Potential Treatment for Fatigue in Parkinson’s Disease? A Systematic Review and Meta-Analysis of Pharmacological and Non-Pharmacological Interventions
Authors: Folkerts Ann-Kristin , Nielsen Jörn , Gollan Romina , Lansu Annika , Solfronk Dominik , Monsef Ina , Ernst Moritz , Skoetz Nicole , Zeuner Kirsten E. , Kalbe Elke 
Published: June 2023

Background: Fatigue is one of the most common and debilitating non-motor symptoms among patients with Parkinson’s disease (PD) and significantly impacts quality of life. Therefore, effective treatment options are needed. Objective: To provide an update on randomized controlled trials (RCTs) including pharmacological and non-pharmacological (but non-surgical) treatments that examine the effects of fatigue on PD patients. Methods: We searched the MEDLINE, EMBASE, PsycINFO, CENTRAL, and CINAHL databases for (cross-over) RCTs on pharmacological and non-pharmacological interventions for treating fatigue in PD patients until May 2021. Meta-analyses for random-effects models were calculated when two or more studies on the same treatment option were available using standardized mean differences (SMDs) with 95% confidence intervals (CIs). Results: Fourteen pharmacological and 16 non-pharmacological intervention RCTs were identified. For pharmacological approaches, a meta-analysis could only be performed for modafinil compared to placebo ( n = 2) revealing a non-significant effect on fatigue (SMD = – 0.21, 95% CI – 0.74–0.31, p = 0.43). Regarding non-pharmacological approaches, physical exercise ( n = 8) following different training approaches versus passive or placebo control groups showed a small significant effect (SMD = – 0.37, 95% CI – 0.69‐ – 0.05, p = 0.02) which could not be demonstrated for acupuncture vs. sham-acupuncture (SMD = 0.16, 95% CI – 0.19–0.50, p = 0.37). Conclusion: Physical exercise may be a promising strategy to treat fatigue in PD patients. Further research is required to examine the efficacy of this treatment strategy and further interventions. Future studies should differentiate treatment effects on physical and mental fatigue as the different underlying mechanisms of these symptoms may lead to different treatment responses. More effort is required to develop, evaluate, and implement holistic fatigue management strategies for PD patients.
Pendidikan Akhlak Peserta Didik Perspektif Syekh Muhammad Syakir dalam Kitab Washoya Al Abaa Lil Abnaa
Authors: Mutiara Sari Auliana Fitri Intam , Wahyudin Undang Ruslan , Mustofa Taufik 
Published: June 2023

Abstract: Moral education has an important role to form students who are intellectually and behaviorally qualified. But what is happening now is the finding of a student's moral crisis which is supported by various immoral between students in schools. This study aims to determine the concept of moral education of students in the book Washoya Al Abaa' Lil Abnaa' by Sheikh Muhammad Syakir. This study uses a qualitative descriptive approach and the type of research used is library research with the data analysis technique used is content analysis. The results of this study indicate that in the book Washoya Al Abaa' Lil Abnaa' by Sheikh Muhammad Syakir there are several concepts of moral education that must be possessed by students including: morals to teachers, morals in making friends, and morals in studying. Keywords: Moral Education, Students, Sheikh Muhammad Syakir Abstrak:. Pendidikan akhlak mempunyai peran penting dalam membentuk peserta didik yang berkualitas secara intelektual dan tingkah laku. Namun yang terjadi sekarang, ditemukannya krisis akhlak seorang peserta didik yang didukung dari berbagai peristiwa amoral di sekolah. Penelitian ini bertujuan untuk mengetahui konsep pendidikan akhlak peserta didik dalam kitab Washoya Al Abaa’ Lil Abnaa’ karya Syekh Muhammad Syakir. Penelitian ini menggunakan pendekatan deskriptif kualitatif dan jenis penelitian yang digunakan adalah penelitian kepustakaan dengan teknik analisis data yang dipakai adalah analisis isi. Hasil penelitian ini menunjukkan bahwa dalam kitab Washoya Al Abaa’ Lil Abnaa’ karya Syekh Muhammad Syakir terdapat beberapa konsep pendidikan akhlak yang harus dimiliki oleh peserta didik di antaranya yaitu: akhlak kepada guru, akhlak dalam berteman, dan akhlak dalam menuntut ilmu. Kata kunci: Pendidikan Akhlak, Peserta Didik, Syekh Muhammad Syakir
Implementasi Pembelajaran Pendidikan Islam Berbasis Literasi Visual dalam Meningkatkan Sikap Spiritual Siswa
Authors: Yudi Wahyudi Wah , Rohma Fit'atur Rohma 
Published: June 2023

Abstract: Lately, there has been a decrease in understanding of the importance of worship caused by the lack of creativity of a teacher in delivering material. In this era of increasingly rapid digital development, it is hoped that a solution can be made to increase students' understanding of the importance of worship for them. The purpose of this study was to analyze a learning method/media in improving spiritual attitudes. and understanding of Islamic religious education materials about prayer procedures with visual literacy-based learning. Visual literacy or audio-visual media is a technology that produces benefits in delivering material using electronics to improve learning outcomes and communicate with students more effectively. The types of this study uses research action. The results of research in the application of visual literacy-based learning methods have a significant impact and can increase students' enthusiasm for learning and make it easier to understand the material taught by the teacher effectively and efficiently. Keyword: visual literacy, spiritual attitude, prayer Abstrak: Akhir-akhir ini terjadi penurunan pemahaman akan pentingnya ibadah yang disebabkan oleh kurangnya kreativitas seorang guru dalam menyampaikan materi. Di era perkembangan digital yang semakin pesat ini diharapkan dapat dibuat suatu solusi untuk meningkatkan pemahaman siswa tentang betapa pentingnya ibadah bagi mereka. Tujuan penelitian ini adalah untuk menganalisis suatu metode/media pembelajaran dalam meningkatkan sikap spiritual. dan pemahaman materi pendidikan agama Islam tentang tata cara shalat dengan pembelajaran berbasis literasi visual. Literasi visual atau media audio visual merupakan teknologi yang menghasilkan manfaat dalam penyampaian materi menggunakan elektronika untuk meningkatkan hasil belajar dan berkomunikasi dengan siswa secara lebih efektif. Penelitian ini menggunakan jenis penelitian tindakan kelas. Hasil penelitian dalam penerapan metode pembelajaran berbasis literasi visual memberikan dampak yang signifikan dan dapat meningkatkan semangat belajar siswa serta memudahkan dalam memahami materi yang diajarkan oleh guru secara efektif dan efisien. Katakunci: literasi visual, sikap spiritual, shalat
METODE HIWAR DALAM PENDIDIKAN ISLAM PERSPEKTIF AL GHAZALI
Authors: Faizin Mohammad , Aziz Yahya , Putri Nurul Hanifah , Albab Azzahra Ulil 
Published: June 2023

Abstract: This research aims to describe and clarify clearly how the interaction of the two components of education, namely educators and students, in the form of dialogue in Islamic education from al-Ghazali's perspective. Research results state that Islamic education is very important because it is the main reference for a person's life from birth to death. According to al-Ghazali, a child's success is determined by the strength of his or her parents and teachers. The emphasis on educators' impact on students is due to this. One of his discoveries on the educational side is the concept of educational interaction in teaching activities between educators and students; this is similar to one of the well-known Islamic educational methods, namely hiwar, or dialogue. This discussion of knowledge or education must be conducted with the full understanding that the speaker's goals include both educating and guiding his or her listener toward maturity. Keywords: Al Ghazali, islamic education, hiwar Abstrak: Riset ini ditujukan guna menguraikan dan memaparkan secara jelas interaksi dua komponen pendidikan.yakni pendidik dan anak didik berbentuk dialog dalam edukasi islam perspektif al.Ghazali. Pengerjaan riset dilakukan melalui pencarian data jadi dari penelusuran dengan media internet. Hasil riset menyatakan edukasi Islam teramat penting karena menjadi acuan utama bagi kehidupan seseorang sejak dia lahir hingga wafat. Bagi al.Ghazali, seorang anak itu tergantung atas bagaimana daya orang tua serta pengajarnya. Dimana ini menjadi penyebab penitikberatan pengaruh pendidik atas anak didik. Satu di antara yang ada atas penemuannya di sisi pendidikan ialah konsep educational interaction dalam aktivitas pengajaran antara pendidik dan anak didik, dan ini serupa dengan satu di antara sejumlah metode edukasi Islam terkenal yakni hiwar atau dialog. Dialog berisi ilmu atau edukasi ini mesti dilakukan dengan kesadaran penuh bahwa dia bermaksud mendidik juga membimbing kawan bicaranya pada maturitas. Keywords: Al Ghazali, edukasi Islam, hiwar
Analisa Hasil Pengukuran Gasket Silinder Head Motor E Menggunakan Profile Projector Pada E Tipe
Authors: Asiang Firman Bagus , Rohmat Nur , Sjahmanto M. 
Published: June 2023

Analisa hasil Pengukuran karya ilmiah ini bertujuan untuk mengetahui jarak dan ukuran dari segi dimensi lubang baud gasket silinder head type motor E menggunakan alat uji profile projector . Untuk mengetahui nilai rata-rata dan nilai deviasi gasket silinder head dilakukan proses penelitian dari pengukuran dengan beberapa sample produk atau benda uji (sempel A dengan bahan plat , sempel B dengan bahan logam, dan sempel C dengan bahan kardus pernis), dimana masing masing tipe berjumlah 1 sempel, pengukuran antar lubang baud sebanyak 6 titik. Pada analisis ini telah dihasilkan nilai rata-rata () dan nilai deviasi () yang berbeda – beda meskipun dalam suatu produk yang sama. Untuk gasket sempel A titik pengukuran dengan nilai rata-rata dari 9.92 mm (titik 3) – 9.92 mm (titik 4), gasket tipe B titik pengukuran dengan nilai rata-rata dari 12.68 mm (titik 1) – 12,48 mm (titik 5), sedangkan tipe C titik pengukuran dengan nilai rata-rata dari 12.2 (titik 1) – 12,2 (titik 6). Dari gasket tipe A, tipe B, dan tipe C yang nilai rata-ratanya rendah dengan jumlah titik paling banyak ada pada gasket tipe C ada 4 titik.Nilai rata-ratanya rendah dengan jumlah titik paling sedikit ada pada gasket tipe B 1 titik. Untuk nilai rata-ratanya tinggi dengan jumlah titik paling banyak ada pada tipe gasket tipe A ada 3 titik, sedangkan nilai rata-ratanya tinggi dengan jumlah titik paling sedikit ada pada gasket tipe C ada 1 titik.kemudian mencari nilai deviasi dari 3 sample yang bebeda dimna di emukan dari semple A nili deviasinya 0.006, kemudian nilai deviasi dari sempel B di temukan 0.33, dan dari semple C di tumukan nilai deviasinya 0.07.
Del autoexilio al viaje de vuelta a la isla: la recuperación de la historia y del lugar propio en Los cristales de la sal, de Cristina Bendek
Authors: Rivas Luz Marina 
Published: June 2023

La novela Los cristales de la sal (2019), de Cristina Bendek, parte del tema del exilio, reiterado en la narrativa del Caribe como región más allá de la nación. En ella se proponen dos viajes hacia la isla de San Andrés, en Colombia: uno simbólico hacia la historia familiar y la historia colectiva y otro geográfico para superar el autoexilio de la protagonista y construir una identidad que supere las tensiones de alteridades incomprendidas.
Cinco escenas transcaribeñas
Authors: Fornet Jorge 
Published: June 2023

De Eric Williams a los miembros del grupo Nuevo Mundo, de Andrew Salkey a Aimé Césaire, de C.L.R. James a Stokely Carmichael, las reflexiones producidas desde el Caribe cobraron una dimensión mayor al cruzarse con la Revolución Cubana y con la lucha por los derechos civiles en los Estados Unidos. La propia Cuba –como puede observarse en estas “escenas”– fue un eje clave en el que confluyeron notables intelectuales para potenciar el pensamiento anticolonialista.
Diagnostic accuracy of scales for depression screening in patients with heart failure: systematic review and meta-analysis
Authors: Cassiani-Miranda Carlos Arturo , Rueda Martin , Anthony Camacho Paul 
Published: June 2023

Introduction: despite the existence of recommendations for the screening depressive symptoms in patients with cardiovascular disease and heart failure (HF), there are no comparative data regarding the performance of psychometric scales used in patients with HF. This study compares the psychometric performance of screening scales used for depressive symptoms in such patients. Methods: PRISMA declaration recommendations were used for the systematic review. MEDLINE, EMBASE, Psychology and Behavioral Sciences Collection, SCOPUS, Lilacs, Australasian Medical Index and the African Index from January 2000 to February 2016 were used for the search. The eligible articles were published in any language and they assessed the psychometric properties of screening scales for depressive symptoms in patients with HF. QUADAS-2 criteria was used for quality assessment, and a meta-analysis developed through a hierarchical model obtained the cluster estimations for sensitivity, specificity, likelihood ratio, predictive values, and diagnostic odds ratio (DOR) with 95% confidence intervals. Results: the initial search identified 1238 citations; only three gathered the inclusion criteria for quantitative assessment. The combined sensitivity and specificity was 56% (95% IC: 45-67%; T2=0.05) and 98% (95% IC: 96-99%; T2=0.01) respectively. The area under the curve was 0.92 (95% IC: 0.90-0.94). The variables related with the index test, reference test, Global QUDAS-2 score, and language predicted heterogeneity. Limitations: significant heterogeneity, small number of studies, selective cutoff report, and the lack of a cost-effectiveness analysis. Conclusions: The GDS-15, HADS-D, PHQ-9, CAT-D and PROMIS scales performed similarly with high specificity values.