bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug survival analysis of dupilumab and associated predictors in patients with atopic dermatitis in South Korea: single-center, retrospective study
Authors: Seul Tae Woong , Park Hyun Woo , Kim Hyo Yoon , Shin Jung Jin , Son Sang Wook 
Published: August 2023

Abstract

Long-term data on dupilumab drug survival in Asia patients with atopic dermatitis (AD) are limited. A single-center, retrospective study was performed to assess drug survival between March 2019 and March 2023. Drug survival and associated characteristics were analyzed using Kaplan–Meier survival curves and multivariate Cox regression analysis, respectively. A total of 124 patients with AD (Mean age [standard deviation], 26.0 [8.6] years) with a 4 years-overall dupilumab drug survival rate of 87.9%, were included in this study. During the same period, drug survival in the 479 cyclosporine patients was 0.2%, statistically different from the dupilumab group (p -value < 0.001). Characteristics associated with shorter drug survival were the low eczema area and severity index (EASI) scores at baseline (hazard ratio [HR], 0.84; 95% confidence interval [CI], 0.75–0.94, p-value = 0.003) and non-insurance coverage of dupilumab (HR, 11.87; 95% CI, 3.28–42.99, p-value = 0.001). This retrospective study demonstrated good overall 4-year dupilumab survival (87.9%) in South Korea. Patients with low baseline EASI scores and those who did not have insurance for dupilumab treatment discontinued the therapy frequently. To the best of our knowledge, this is the first long-term dupilumab drug survival study conducted in Asia with predictors.
Cybersecurity Management System of the Czech Republic
Authors: Červený Vlastimil , Hromada Martin , Jašek Roman 
Published: August 2023

Abstract

Today, our lives, work and relationships are interconnected and completely dependent on information technologies and communication networks. Modern society has created cyberspace as an extension of our lives, which has brought us many positive things, but also many new risks that need to be managed. Every organization, whether in the public or private sector, must have a cybersecurity management system in place to survive and prosper in this environment. However, how is the cybersecurity management system established at the state level? Is it possible to consider a state as a certain type of large and complex organization and implement a cybersecurity management system similar to those used by companies and smaller institutions? This article attempts to answer these questions by analyzing the cybersecurity management system at the level of the Czech Republic and by identifying and discussing the specifics of cybersecurity management at the state level.
In-situ growth of SiC w on the surface of C/C composite materials and different influencing factors on the morphology control of SiC w transition layer
Authors: Xie Chen , Jiang Yun , Chen Jingtao , Min Jiahua , Zhang Jijun , Liang Xiaoyan , Hu Pengfei 
Published: August 2023

Abstract
The in-situ growth of SiC whisker (SiCw) buffer layer on the surface of C/C composite material substrates provides an excellent solution to alleviate the thermal stress mismatch with the oxidation-resistant coating. Nevertheless, the growth mechanism of SiCw on the surface of C/C composite materials has been a subject of ongoing debate. This study initially investigates the reduction process of Ni(NO3)2·6H2O as a catalyst precursor and analyzes the morphological impact of Ni nanoparticles on the surface of C/C composite materials with respect to SiCw. Furthermore, it summarizes the V-L-S growth mechanism and V-S mechanism of SiCw, providing a comprehensive analysis of the microstructure and defects associated with SiCw growth under different mechanisms. The catalytic mechanism of Ni particles and the role of twinning and Z-shaped dipoles in whisker growth are elucidated. Finally, the influence of temperature and time on whisker morphology is examined, with particular emphasis on the occurrence of bead-like whiskers. This research extensively elucidates the growth process of SiCw on C/C composite substrate, resolving the previously ambiguous growth mechanism through structural analysis under diverse conditions.
Women mental wellbeing in the adverse context: Evidence from Vietnam
Authors: Nguyen Vy Thi To , Duy Luong Vinh Quoc 
Published: August 2023

Abstract
Background:
Women’s health and wellbeing is of great concern to many developing countries. However, the topic on women mental wellbeing in developing countries is not adequately covered by academic studies. Our study is an endeavor amid the pandemic to investigate Vietnam women’s mental wellbeing and its associations.
Methods
A questionnaire survey on women including items on WHO-5 wellbeing, OECD wellbeing, demographics, education, and economic background. There were 519 women located in the city and province as Bac Ninh, Ha Tinh, Gia Lai, Lam Dong and Ho Chi Minh City participated in the survey. Correlational analysis was used to the associations between women’s mental wellbeing and other factors.
Results
Results from our study show statistically significant associations between women mental wellbeing and their marriage status, education, job, wage, age, children, and household appliances.
Conclusions
We suggest that social and economic policies should be well-coordinated to improve women mental wellbeing amid the adverse context.
Advantages of cone beam computed tomography for evaluation of subchondral insufficiency fractures of the knee compared with MRI
Authors: Delsmann Maximilian , Delsmann Julian , Jandl Nico Maximilian , Maas Kai-Jonathan , Beil Frank Timo , Amling Michael , Henes Frank Oliver , Rolvien Tim , Spink Clemens 
Published: August 2023

Abstract

Purpose To determine the diagnostic yield of cone beam computed tomography (CBCT) compared with 3T magnetic resonance imaging (MRI) for the evaluation of subchondral insufficiency fractures of the knee. Methods Consecutive patients with subchondral insufficiency fractures of the knee examined by 3T MRI and CBCT of the femoral condyles were reviewed. Two experienced raters graded the lesion severity on 3T MRI and CBCT images: grade 1: no signs of a subchondral bone lesion; grade 2: subchondral trabecular fracture or cystic changes, but without infraction of the subchondral bone plate; grade 3: collapse of the subchondral bone plate. Ratings were repeated after six weeks to determine reliability. In addition, the bone lesion size was measured as elliptical area (mm2) and compared between CBCT and T1-weighted MRI sequences. Results Among 30 patients included (43.3% women; mean age: 60.9 ± 12.8 years; body mass index (BMI) 29.0 ± 12.8 kg/m2), the medial femoral condyle was affected in 21/30 patients (70%). The grading of subchondral lesions between MRI and CBCT did not match in twelve cases (40%). Based on MRI images, an underestimation (i.e., undergrading) compared with CBCT was observed in nine cases (30%), whereas overgrading occurred in three cases (10%). Compared to CBCT, routine T1-weighted 3T sequences significantly overestimated osseus defect zones in sagittal (84.7 ± 68.9 mm2vs.35.9 ± 38.2 mm2, p < 0.01) and coronal orientation (53.1 ± 24.0 mm2vs.22.0 ± 15.2 mm2, p < 0.01). The reproducibility of the grading determined by intra- and inter-rater agreement was very high in MRI (intra-class correlation coefficient (ICC) 0.78 and 0.90, respectively) and CBCT (ICC 0.96 and 0.96, respectively). Conclusion In patients with subchondral insufficiency fractures of the knee, the use of CBCT revealed discrepancies in lesion grading compared with MRI. These findings are clinically relevant, as precise determination of subchondral bone plate integrity may influence the decision about conservative or surgical treatment. CBCT represents our imaging modality of choice for grading the lesion and assessing subchondral bone plate integrity. MRI remains the gold standard modality to detect especially early stages.
Enhancing postpartum nursing experiences through information technology-enabled services: An integration of systems theory and a patient-centered perspective
Authors: Hung Chih-Lung , Chang Te-Min , Chang Yie-Jie , Huang Pei-Chen , Hsieh Ming-Che , Chen Yi-Cheng , Lin Li-Min , Wu Jen-Her 
Published: August 2023

Abstract
Postpartum nursing care, which is critical to sustaining women’s health and wellness, has undergone a major shift in focus toward patient-centered and coordinated care. However, this shift has been hindered by the persistence of traditional practices in which patients are regarded as passive receivers of health care and by the presence of a fragmented health-care system with dynamic complexity. Implementing modern postpartum nursing care in which information technology (IT) enabled services are utilized can enable health-care organizations to bridge service gaps. The current study proposes an IT-enabled service design methodology (ISDM) that integrates systems theory and a patient-centered perspective to create a design roadmap to meet postpartum mothers’ needs. The usability and feasibility of the ISDM are evaluated through a case study of the E-DA BASSINET postpartum nursing center. The results indicate that implementation of the ISDM can effectively facilitate the transformation of postpartum nursing services into patient-centered services, which can substantially enhance satisfaction among postpartum mothers during their nursing care journey.
What is day programme treatment for Anorexia Nervosa really like? A reflexive thematic analysis of five years of feedback from young people
Authors: Gledhill Lucinda J. , MacInnes Danielle , Chan Sze Chi , Drewery Charlotte , Watson Charlotte , Baudinet Julian 
Published: August 2023

Abstract
Background:
A significant proportion of young people do not respond to the NICE recommended treatment for anorexia nervosa: Family Therapy. Whilst historically these young people would be admitted to inpatient services, which are associated with greater treatment cost, greater risk of relapse, and worse outcome, more recently evidence is building for the effectiveness of day programmes. One day programme that has been found to be effective is the Intensive Treatment Programme (ITP) of the Maudsley Centre for Child & Adolescent Eating Disorders in London, UK. However, to-date no studies have investigated how young people experience such a day programme.
Method:
Anonymous feedback was completed via online survey by 51 young people over a 5-year period (2018-2023) on discharge from ITP.
Results:
Four main themes were identified: (1) Support - young people expressed the importance of boundaries but also of feeling validated, and encouraged; (2) Uniqueness: an experience like no other - ITP was described as different to any other treatment received before (both outpatient and inpatient); (3) Relationships – young people valued connecting with others in a similar situation and reflected that relationships at home changed throughout treatment; (4) Self-development – learning skills, developing independence, and exploring an identity outside of the eating disorder was valued.
Conclusions:
It is hoped that the reflections from these young people can help to inform clinicians working in DPs and those hoping to set up novel DPs about key aspects of treatment.
Multicomponent Reaction Based Tolyl-substituted and Pyrene-Pyridine Conjugated Isomeric Ratiometric Fluorescent Probes: A Comparative Investigation of Photophysical and Hg(II)-Sensing Behaviors
Authors: Niranjan Raghvendra , Prasad G. Durga , Achankunju Simi , Arockiaraj Mariyaraj , Velumani Kotteswaran , Nachimuthu Kiruthika , Sundramoorthy Ashok K. , Neogi Ishita , Nallasivam Jothi L. , Rajeshkumar Venkatachalam , Mahadevegowda Surendra H. 
Published: August 2023

Abstract
Herein, the synthesis of pyrene conjugated 2,6-di-ortho-tolylpyridine and 2,6-di-para-tolylpyridine structural isomers were achieved efficiently through multicomponent Chichibabin pyridine synthesis reaction. The DFT, TD-DFT and experimental investigations were carried out to investigate the photophysical behaviors of the synthesized novel pyrene-pyridine based isomeric probes. Our studies revealed that, due to the continuous conjugation of the pyrene, pyridine and tolyl moieties, the dihedral angles of the trisubstituents on the central pyridine moiety significantly influences the photophysical properties of the synthesized novel pyrene based fluorescent probes. Further, we have comparatively investigated the sensing behaviors of the synthesized tolyl-substituted isomeric ratiometric fluorescent probes with metal ions, our studies reveals that both the ortho and para tolyl ratiometric fluorescent probes have distinct photoemissive properties in selectively sensing of Hg2+ ions. Our studies indicates that, the para-tolyl substituted isomer displays more red-shift in wavelength of emission band compared to its ortho isomer analogue during ratiometric fluorescent specific detection of Hg2+ ions.
Vegetation–soil–microbiota dynamics across a 50-year grassland chronosequence: implications for desertified land restoration in the loess hilly region of China
Authors: Ma Yuanyuan , Shen Yan , Jin Ling , Tian Yu , Ma Hongbin , Lan Jian , Fu Bingzhe 
Published: August 2023

Abstract

Purpose
Alfalfa (Medicago sativa L.) establishment is an effective strategy for restoring degraded grasslands. However, the mechanisms underlying ecological restoration in reconstructed grasslands following alfalfa establishment are still poorly understood. This study investigated vegetation community, soil quality and rhizosphere microbiota dynamics across a reconstructed grassland chronosequence in the loess region of Northwest China.
Methods
A space-for-time substitution method was used to evaluate vegetation coverage and alfalfa production performance in grassland stands with different ages (1–50 years old). High-throughput sequencing was conducted to characterise microbial communities in rhizosphere soils.
Results
The plant heights, yields and stem-to-leaf ratios of alfalfa all peaked in the seven-year-old stand and then decreased in older stands, with Stipa bungeana replacing alfalfa as the dominant species in the 50-year-old stand. Soil bulk density and major nutrient contents were highest in the artificial grassland (1–10 years). Soil enzyme activities (e.g., urease and sucrase) were enhanced in the transitional grassland (10–30 years), accompanied by enrichment of potentially beneficial microorganisms (e.g., Actinobacteria and Mortierella) and functional fungi (e.g., saprotrophs and symbiotrophs). Soil water content, total porosity and microbial diversity reached their maximum levels in the natural grassland (> 30 years).
Conclusions
The results indicated that alfalfa establishment altered soil structure and nutrient status over the short term, subsequently creating an optimal rhizosphere micro-environment. The improved soil conditions and rhizosphere microbiota were favourable for establishment of native grass species, leading to the formation of a stable natural ecosystem.
The safety and efficacy of intra-arterial low dose tirofiban administration during endovascular therapy in patients with large ischemic core volume
Authors: Cho Kwang-Chun , Son Nak-Hoon , Gwon So Hyeon , Choi Jin Wook , Jung Woo Sang 
Published: August 2023

Abstract

This study aimed to evaluate the safety and efficacy of intra-arterial (IA) administration of low dose tirofiban during endovascular therapy in patients with large ischemic volumes on initial brain CT. Patients were divided into two groups based on the use of IA tirofiban. We identified 87 patients (16 and 71 patients in the tirofiban and no-tirofiban groups, respectively) with acute ischemic stroke due to intracranial artery occlusion who underwent endovascular therapy with a low Alberta Stroke Program Early CT scores (2–5). Multivariate logistic regression analysis revealed no association between IA tirofiban administration and serious postprocedural haemorrhagic complications (adjusted odds ratio (aOR), 0.720; 95% confidence interval (CI), 0.099–5.219; p = 0.960), any radiologic haemorrhage (aOR 0.076; 95% CI, 0.003–2.323; p = 0.139), or 3-month mortality (aOR, 0.087; 95% CI, 0.005–1.501; p = 0.093). However, IA tirofiban was associated with a lower 90-day mRS score (aOR, 0.197; 95% CI, 0.015–1.306; p = 0.017) and change in NIHSS score from baseline (aOR, 0.698; 95% CI, 0.531–0.917; p = 0.010). IA tirofiban administration during endovascular therapy in patients with large ischemic volumes may be effective and safe.
Crossing Boundaries and Time: An Exploration of Time Allocation and Emotional Well-Being of Immigrants in the United States *
Authors: Coniglio Nicola Daniele , Hoxhaj Rezart , lagravinese raffaele 
Published: August 2023

Abstract

This study investigates the emotional experiences of immigrants and native-born individuals in the United States, exploring the relationship between daily activities and feelings of happiness, stress, and meaningfulness. We analyze the entire range of daily activities and their durations, utilizing data from the American Time-Use Survey (ATUS) Well-Being modules. The results reveal that when viewed through the evaluation lenses of the general US population, immigrants engage in less happy, more stressful, and less meaningful activities compared to natives. However, when considering subjective emotional assessments, immigrants are more optimistic and perceive these activities as associated with higher levels of happiness and meaningfulness. The study also finds evidence of emotional assimilation over time, with happiness disparities between immigrants and natives diminishing. In particular, this process appears incomplete for second-generation immigrants. The findings highlight the importance of recognizing the different perspectives of immigrants to formulate inclusive policies that facilitate integration.
JEL codes: J15, J22, I31, Z13
Denoising of Blasting Vibration Signals Based on CEEMDAN- ICA Algorithm
Authors: Bai Wenjun , Chang Yingjie 
Published: August 2023

Abstract

Monitoring of blasting vibration signals can make the collected blasting signals noisy due to various factors such as on-site actual construction conditions, equipment, and instruments. Thus, the acquired signals should be preprocessed before analyzing the blasting vibration signals. The current study proposes a blasting vibration denoising method based on CEEMDAN-ICA to alleviate the noise component in the blasting signals effectively. The collected signal is first decomposed through the CEMMDAN algorithm to extract the IMF components of different frequency bands. Next, the collected signal is estimated using the ICA algorithm to attain corresponding ICA components. Finally, the arrangement entropy of the ICA components is calculated for signal reconstruction to attain a noise-free blasting vibration signal. Simulations are performed to evaluate the feasibility of the presented algorithm and compare its efficiency with the traditional algorithms. The results demonstrate that this algorithm has specific advantages over other algorithms, which can more accurately denoise the original signal and retain the effective signals, providing a new denoising method for subsequent signal analysis.
Genetic Association between Obesity, Arm Fat Percentage, Leg Fat Percentage, and Risk of Migraine: A Two-Sample Mendelian Randomization Study
Authors: Tian Dachen , Wang Mengen , Ning Zhaoteng , Wu Jincheng , Wang Xianjun 
Published: August 2023

Abstract

Background:
Migraine, a prevalent neurological disorder, has attracted considerable attention due to its complex etiology and potential links with traits related to obesity. This study utilizes a robust two-sample Mendelian randomization (MR) framework to explore potential genetic connections between obesity, arm fat percentage (AFP, left), leg fat percentage (LFP, right), and migraine risk.
Methods:
This study conducted a rigorous two-sample Mendelian randomization (MR) analysis using comprehensive summary-level data from genome-wide association studies (GWAS) involving obesity, AFP (left), LFP (right), and migraine. Genetic instruments were carefully chosen based on firmly established connections with the corresponding traits. The MR analysis employed various methods, including inverse variance weighted (IVW), weighted median, and MR-Egger, to evaluate causal relationships and potential pleiotropy.
Results:
The findings offer strong evidence indicating a possible causal link between obesity and a decreased migraine risk (IVW: odds ratio [OR] = 0.91, 95% confidence interval [CI] = 0.85–0.97). Moreover, the MR analysis indicates a comparable potential causal connection between arm fat percentage (left) and a reduced risk of migraine (IVW: OR = 0.85, 95% CI = 0.75–0.98). However, no substantial causal link was found between leg fat percentage (right) and migraine risk in this study (IVW: OR = 0.99, 95% CI = 0.85–1.16).
Conclusion:
This two-sample Mendelian randomization investigation illuminates the complex interplay between obesity-related traits and migraine risk. The findings imply a potential protective effect of obesity and arm fat percentage (left) against migraine risk, suggesting a novel approach for investigating preventive strategies. In contrast, there was no substantial causal connection observed between leg fat percentage (right) and migraine risk. These findings emphasize the significance of additional research to clarify the underlying mechanisms and clinical implications of these associations.
The rehabilitation workforce in Brazil
Authors: Sixel Taciana Rocha dos Santos , Bernardo Debora , Medeiros Arthur de Almeida , Bousquat Aylene , Mota Paulo Henrique dos Santos , Schmitt Ana Carolina Basso 
Published: August 2023

Abstract
Background: Demand for rehabilitation services has been increasing due to the increase of individuals with functional impairment. It is essential to know the supply of the rehabilitation workforce to better plan the health system to meet the health needs of the population.
Objective: To investigate the spatial and temporal distribution of physical therapists, speech therapists, psychologists and occupational therapists across the levels of care within the Brazilian Unified Health System and its regions.
Method: This is an ecological time series study on the supply of rehabilitation professionals. Data were obtained from the National Register of Health Establishments from 2007 to 2020. The density of professionals was calculated per 10,000 inhabitants per year for Brazil and its five regions. The Joinpoint regression model was used to analyze the temporal trends of the density of professionals, considering the 95% confidence interval.
Results: In 2020, the most notable concentrations of psychologists, speech therapists, and occupational therapists in Brazil were observed in the domain of Specialized Health Care, with densities of 0.60, 0.20, and 0.16 professionals per 10,000 inhabitants, respectively. Conversely, the highest density of physical therapists was found in the context of Hospital Health Care, with a density of 1.19 professionals per 10,000 inhabitants. Notably, variations in professional distribution across different regions were apparent. Primary Health Care exhibited the highest density of professionals in the Northeast region, while the Southern region accounted for the highest densities in all professional categories within Specialized Health Care. The southeast region demonstrated the largest workforce within Hospital Health Care. A considerable increase in the availability of professionals was observed across all categories, with the most substantial growth seen in the occupational therapy sector within hospital care (AAPC: 30.8), despite its low density.
Conclusion: The implementation of public health policies has played a significant role in the expansion of the rehabilitation workforce at all three levels of care in Brazil and its various regions from 2007 to 2020. Consequently, regional disparities and densities of professionals have emerged, resembling patterns observed in low-income countries.