bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonsimilar forced convection analysis of maxwell nanofluid flow over an exponentially stretching sheet with convective boundary conditions
Authors: Razzaq Raheela , Farooq Umer , Mirza Hasan Raza 
Published: July 2023

AbstractThis proposed work aims to describe nonsimilar forced convection analysis for the flow of Maxwell nanofluids. The forced flow is commenced due to the stretching surface (SS) at an exponential rate. Heat and mass transmission is tackled with convective and zero mass flux at the surface. The fundamental laws of conservation governing the present flow problem are expressed mathematically in the form of a nonlinear partial differential system. The differential system is then remodeled into a system of nonlinear dimensionless partial differential equations (PDEs) under the implementation of suitable nonsimilar transformations. The resulting nonsimilar system is analytically approximated by applying local nonsimilarity (LNS) and then using the finite‐difference based bvp4c algorithm, it is numerically simulated to ascertain the influences of the various parameters—including the; Deborah number, Biot number, Schmidt number, Brownian diffusion parameter, Prandtl number, and thermophoresis diffusion parameters, on velocity and temperature. The reduced Nusselt numbers and the conduct of velocity and thermal distribution for varying parameters are illustrated graphically. The reduction of the boundary layer (BL) thickness is measured because‐of the Biot number while an increase is observed with an elevation in Deborah number. The velocity configuration is reduced with expanding Deborah number. It is remarked that as the values of the thermophoresis and Brownian motion parameter rise, the thermal BL thickness expands, and at the surface, the temperature gradient demises. An excellent comparison is noticed between present works with the already published article. The novelty of this article is that most of realworld BL flow problems are nonsimilar in nature, while many research have neglected this fact and treated the problem as similar. Therefore, we talked about the Maxwell problem's nonsimilar analysis here. The author's observations indicate that the analysis of the topic under discussion has not yet been declared in published literature.
Applying the HIV Prevention Cascade to an Evaluation of a Large-Scale Combination HIV Prevention Programme for Adolescent Girls and Young Women in South Africa
Authors: Bergh Kate , Toska Elona , Duby Zoe , Govindasamy Darshini , Mathews Catherine , Reddy Tarylee , Jonas Kim 
Published: July 2023

AbstractAdolescent girls and young women (AGYW) in South Africa are at a three times higher risk of acquiring HIV than their male counterparts. The HIV prevention cascade is a tool which can be used to measure coverage of HIV prevention services, although there is limited empirical evidence to demonstrate its application in low-resourced settings. The unifying framework is a conceptualisation of the HIV prevention cascade which theorises that both motivation and access are required for an individual to effectively use an HIV prevention method. We applied this framework to data from a random sample of 127,951 beneficiaries of a combination HIV prevention programme for AGYW aged 15–24 in South Africa to measure the steps to, and identify key barriers to, effective use of male condoms and oral pre-exposure prophylaxis (PrEP) among this vulnerable population. Barriers to each step were analysed using univariate and multivariable logistic regression. Among self-reported HIV-negative AGYW who had sex in the past 6 months, effective use of condoms (15.2%), access to PrEP (39.1%) and use of PrEP (3.8%) were low. AGYW were: less likely to be motivated to use condoms if they believed that they had a faithful partner (aOR 0.44, 95% CI 0.22–0.90) or disliked condoms (aOR 0.26, 95% CI 0.11–0.57), less likely to access condoms if the place where AGYW accessed them was far away (aOR 0.25, 95% CI 0.10–0.64), more likely to effectively use condoms if they received counselling on how to use them (aOR 2.24, 95% CI 1.05–4.76), less likely to be motivated to use PrEP if they did not believe PrEP was efficacious (aOR 0.35, 95% CI 0.17–0.72), more likely to be motivated if they felt confident that they could use PrEP, and more likely to have access to PrEP if they had ever been offered PrEP (aOR 2.94, 95% CI 1.19–7.22). This combination HIV prevention programme and similar programmes should focus on risk-reduction counselling interventions for AGYW and their male partners to improve effective use of condoms and ensure easy access to condoms and PrEP by making them available in youth-friendly spaces. Our findings demonstrate that the application of HIV prevention cascades can inform AGYW HIV prevention programming in low-resourced settings.
Integrative analysis of genes reveals endoplasmic reticulum stress-related immune responses involved in dilated cardiomyopathy with fibrosis
Authors: Li Wanpeng , Liu Peiling , Liu Huilin , Zhang Fuchun , Fu Yicheng 
Published: July 2023

AbstractEndoplasmic reticulum (ER) stress has been implicated in the mechanisms underlying the fibrotic process in dilated cardiomyopathy (DCM) and results in disease exacerbation; however, the molecular details of this mechanism remain unclear. Through microarray and bioinformatic analyses, we explored genetic alterations in myocardial fibrosis (MF) and identified potential biomarkers related to ER stress. We integrated two public microarray datasets, including 19 DCM and 16 control samples, and comprehensively analyzed differential expression, biological functions, molecular interactions, and immune infiltration levels. The immune cell signatures suggest that inflammatory immune imbalance may promote MF progression. Both innate and adaptive immunity are involved in MF development, and T-cell subsets account for a considerable proportion of immune infiltration. The immune subtypes were further compared, and 103 differentially expressed ER stress-related genes were identified. These genes were mainly enriched in neuronal apoptosis, protein modification, oxidative stress reaction, glycolysis and gluconeogenesis, and NOD-like receptor signaling pathways. Furthermore, the 15 highest-scoring core genes were identified. Seven hub genes (AK1, ARPC3, GSN, KPNA2, PARP1, PFKL, and PRKC) might participate in immune-related mechanisms. Our results offer a new integrative view of the pathways and interaction networks of ER stress-related genes and provide guidance for developing novel therapeutic strategies for MF.
Spectral Laplace Transform of Signals on Arbitrary Domains
Authors: Patané Giuseppe 
Published: July 2023

AbstractThe Laplace transform is a central mathematical tool for analysing 1D/2D signals and for the solution to PDEs; however, its definition and computation on arbitrary data is still an open research problem. We introduce the Laplace transform on arbitrary domains and focus on thespectral Laplace transform, which is defined by applying a 1D filter to the Laplacian spectrum of the input domain. The spectral Laplace transform satisfies standard properties of the 1D and 2D transforms, such as dilation, translation, scaling, derivation, localisation, and relations with the Fourier transform. The spectral Laplace transform is enough general to be applied to signals defined on different discrete data, such as graphs, 3D surface meshes, and point sets. Working in the spectral domain and applying polynomial and rational polynomial approximations, we achieve a stable computation of the spectral Laplace Transform. As main applications, we discuss the computation of the spectral Laplace Transform of functions defined on arbitrary domains (e.g., 2D and 3D surfaces, graphs), the solution of the heat diffusion equation, and graph signal processing.
The Boundary Problem in Democratic Theory: A Methodological Approach
Authors: Magaña Pablo 
Published: July 2023

AbstractHow should political power and influence be allocated in democratic systems? That is, roughly, the core of the boundary problem in democratic theory. As of late, some authors have begun paying increased attention to the methodological aspects of this dispute. This paper attempts to make a twofold contribution to this ‘methodological turn’. On the one hand, it identifies and analyzes five desiderata of a successful principle of democratic inclusion. Any such principle, I argue, must be grounded in a clearly identifiable set of values, must provide a clear standard of inclusion, must specify the relevant modalities of inclusion, must provide sound bridging principles, and must be extensionally adequate. In the first half of the paper, these desiderata are developed and critically scrutinized. On the other hand, I also extract three lessons from the previous discussion. First, that a unique answer to the boundary problem (i.e. one grounded in one single principle) is unlikely. Second, that a satisfactory answer to the boundary problem need not necessarily appeal, as some have argued, to distinctively democratic values. And third, that intuitions about political exclusion (i.e. those requiring or permitting the exclusion of some individuals) should be treated with special caution.
Youth and Parent Perspectives on Sexual Health Education for People with Intellectual Disabilities
Authors: Colarossi Lisa , Riquelme Marlene O. , Collier Kate L. , Pérez Siana , Dean Randa 
Published: July 2023

AbstractYouth with intellectual disabilities face barriers to receiving sex education including the lack of educational tools accessible for multiple cognitive and emotional learning styles. We conducted exploratory research to gather input from a diverse group of youth with disabilities and their guardians about needed learning modalities and sexual health content areas. Three focus groups were conducted with youth ages 17–28 years (n = 14) and three with parents (n = 16). An applied thematic analysis of the transcripts resulted in three structural codes related to topics of greatest interest for youth sexuality education, teaching tools and methods, and needs for ancillary parent education and support to help youth access information and health care. We identified a total of ten themes associated with the three structural codes. Next steps will be to create educational resource prototypes that are responsive to focus group input for testing in further research.
The SWAP Filter: A Simple Azimuthally Varying Radial Filter for Wide-Field EUV Solar Images
Authors: Seaton Daniel B. , Berghmans David , Bloomfield D. Shaun , De Groof Anik , D’Huys Elke , Nicula Bogdan , Rachmeler Laurel A. , West Matthew J. 
Published: July 2023

AbstractWe present the SWAP Filter: an azimuthally varying, radial normalizing filter specifically developed for EUV images of the solar corona, named for the Sun Watcher with Active Pixels and Image Processing (SWAP) instrument on the Project for On-Board Autonomy 2 (PROBA2) spacecraft. We discuss the origins of our technique, its implementation and key user-configurable parameters, and highlight its effects on data via a series of examples. We discuss the filter’s strengths in a data environment in which wide field-of-view observations that specifically target the low signal-to-noise middle corona are newly available and expected to grow in the coming years.
Utilisation of a Delphi study to understand effective entrepreneurship education in schools
Authors: Hardie Bethany , Lee Kerry , Highfield Camilla 
Published: July 2023

AbstractResearch into how teachers and leaders successfully implement effective entrepreneurship education is vital to developing student’s entrepreneurial mindsets to navigate opportunities in a post-COVID environment. Identifying professional practice that supports the effective implementation of an engaging entrepreneurial curriculum in schools is critical to the success of programmes. Recent studies have rarely consulted stakeholders, school leaders, or entrepreneurs in determining the characteristics for entrepreneurship education. This study describes the investigation of the literature on the contemporary methodologies of entrepreneurial education research and proposes the use of Delphi techniques to harness the collective knowledge of experts to efficiently define current key indicators of effective entrepreneurship education in primary and secondary schools. We justify the rationale for a Delphi study because, in such unstable economic times across the globe, establishing a localised and contemporary entrepreneurship research framework will support the interrogation and identification of effective school programmes.
Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model
Authors: Park Jung-Eun , Lee Jiyoun , Ok Soonhyuck , Byun Seunghee , Chang Eun-Ju , Yoon Sung-Eun , Kim Young-Joon , Kang Min-Ji 
Published: July 2023

AbstractThe endoplasmic reticulum (ER) is a subcellular organelle essential for cellular homeostasis. Perturbation of ER functions due to various conditions can induce apoptosis. Chronic ER stress has been implicated in a wide range of diseases, including autosomal dominant retinitis pigmentosa (ADRP), which is characterized by age-dependent retinal degeneration caused by mutant rhodopsin alleles. However, the signaling pathways that mediate apoptosis in response to ER stress remain poorly understood. In this study, we performed an unbiased in vivo RNAi screen with a Drosophila ADRP model and found that Wg/Wnt1 mediated apoptosis. Subsequent transcriptome analysis revealed that ER stress-associated serine protease (Erasp), which has been predicted to show serine-type endopeptidase activity, was a downstream target of Wg/Wnt1 during ER stress. Furthermore, knocking down Erasp via RNAi suppressed apoptosis induced by mutant rhodopsin-1 (Rh-1P37H) toxicity, alleviating retinal degeneration in the Drosophila ADRP model. In contrast, overexpression of Erasp resulted in enhanced caspase activity in Drosophila S2 cells treated with apoptotic inducers and the stabilization of the initiator caspase Dronc (Death regulator Nedd2-like caspase) by stimulating DIAP1 (Drosophila inhibitor of apoptosis protein 1) degradation. These findings helped identify a novel cell death signaling pathway involved in retinal degeneration in an autosomal dominant retinitis pigmentosa model.
The contribution of morbidity and unemployment for the reduced labor market participation of individuals with neurofibromatosis 1 in Finland
Authors: Kallionpää Roope A. , Johansson Edvard , Böckerman Petri , Peltonen Juha , Peltonen Sirkku 
Published: July 2023

AbstractNeurofibromatosis 1 (NF1) is a multisystem disorder associated with, for example, a high risk for cancer, a variety of behavioral and cognitive deficits, low educational attainment and decreased income. We now examined the labor market participation of individuals with NF1. We analyzed the numbers of days of work, unemployment, and sickness allowance among 742 Finnish individuals with NF1 aged 20–59 years using nationwide register data from Statistics Finland and the Social Insurance Institution of Finland. The individuals with NF1 were compared with a control cohort of 8716 individuals matched with age, sex, and the area of residence. Individuals with NF1 had a significantly lower number of working days per year than the controls (rate ratio [RR] 0.93, 95% CI 0.91–0.95). Unemployment (RR 1.79, 95% CI 1.58–2.02), and sickness absence (RR 1.44, 95% CI 1.25–1.67) were more frequent in the NF1 than in the control group. The causes of sickness allowances were highly concordant with the previously reported morbidity profile of NF1 including neoplasms, cardiovascular disease, mental and behavioral diseases, and neurological diseases. In conclusion, NF1 significantly interferes with labor market participation via both unemployment and morbidity. Unemployment seems to cause more days of not working than sickness absence.
Retrospective analysis of 261 autopsies of penetrating cardiac injuries with emphasis on sociodemographic factors
Authors: Isaza-Restrepo Andres , Donoso-Samper Andrea , Benitez Elkin , Martin-Saavedra Juan Sebastian , Toro Asdhar , Ariza-Salamanca Daniel Felipe , Arredondo Nora , Molano-Gonzales Nicolas , Pinzon-Rondon Angela Maria 
Published: July 2023

AbstractPenetrating cardiac injuries (PCIs) are highly lethal and several factors are related to its incidence and mortality. While most studies focus on characterizing patients who arrived at a medical facility alive and exploring the relationship between the degree of heart compromise and mortality, our study delved deeper into the topic. This study analyzed 261 autopsy reports from 2017 in Bogotá, Colombia, and characterized the factors surrounding PCI incidence and mortality while emphasizing the role of sociodemographic variables. Of these cases, 247 (94.6%) were males with a mean age of 29.19 ± 9.7 years. Weekends, holidays, and late hours had the highest incidence of PCIs. The victims' deaths occurred at the scene in 66 (25.3%) cases, and 65.1% of the victims died before receiving medical care. Upon admission, patients with vital signs were more likely to have been transported by taxi or a private vehicle. Two or more compromised cardiac chambers, increased time of transportation, trauma occurred in the city outskirts, and gunshot wounds were related to increased mortality. Our data is valuable for surgeons, health system managers, and policy analysts as we conducted a holistic assessment of the anatomical and sociodemographic factors that are closely associated with mortality following a PCI. Surgeons must recognize that PCIs can occur even when the entrance wound is outside the cardiac box. Reinforcing hospital infrastructure in the outskirts and improving the availability, accuracy, and response time of first responders may lead to improved patient mortality rates.
Human blood neutrophils generate ROS through FcγR-signaling to mediate protection against febrile P. falciparum malaria
Authors: Ofori Ebenezer Addo , Garcia-Senosiain Asier , Naghizadeh Mohammad , Kana Ikhlaq Hussain , Dziegiel Morten Hanefeld , Adu Bright , Singh Subhash , Theisen Michael 
Published: July 2023

AbstractBlood phagocytes, such as neutrophils and monocytes, generate reactive oxygen species (ROS) as a part of host defense response against infections. We investigated the mechanism of Fcγ-Receptor (FcγR) mediated ROS production in these cells to understand how they contribute to anti-malarial immunity. Plasmodium falciparum merozoites opsonized with naturally occurring IgG triggered both intracellular and extracellular ROS generation in blood phagocytes, with neutrophils being the main contributors. Using specific inhibitors, we show that both FcγRIIIB and FcγRIIA acted synergistically to induce ROS production in neutrophils, and that NADPH oxidase 2 and the PI3K intracellular signal transduction pathway were involved in this process. High levels of neutrophil ROS were also associated with protection against febrile malaria in two geographically diverse malaria endemic regions from Ghana and India, stressing the importance of the cooperation between anti-malarial IgG and neutrophils in triggering ROS-mediated parasite killing as a mechanism for naturally acquired immunity against malaria.
Roles of inter- and intramolecular tryptophan interactions in membrane-active proteins revealed by racemic protein crystallography
Authors: Lander Alexander J. , Mercado Laura Domínguez , Li Xuefei , Taily Irshad Maajid , Findlay Brandon L. , Jin Yi , Luk Louis Y. P. 
Published: July 2023

AbstractTryptophan is frequently found on the surface of membrane-associated proteins that interact with the lipid membrane. However, because of their multifaceted interactions, it is difficult to pinpoint the structure-activity relationship of each tryptophan residue. Here, we describe the use of racemic protein crystallography to probe dedicated tryptophan interactions of a model tryptophan-rich bacteriocin aureocin A53 (AucA) by inclusion and/or exclusion of potential ligands. In the presence of tetrahedral anions that are isosteric to the head group of phospholipids, distinct tryptophan H-bond networks were revealed. H-bond donation by W40 was critical for antibacterial activity, as its substitution by 1-methyltryptophan resulted in substantial loss of activity against bacterial clinical isolates. Meanwhile, exclusion of tetrahedral ions revealed that W3 partakes in formation of a dimeric interface, thus suggesting that AucA is dimeric in solution and dissociated to interact with the phosphate head group in the presence of the lipid membrane. Based on these findings, we could predict the tryptophan residue responsible for activity as well as the oligomeric state of a distant homologue lacticin Q (48%).
Reforestation policies around 2000 in southern China led to forest densification and expansion in the 2010s
Authors: Tong Xiaowei , Brandt Martin , Yue Yuemin , Zhang Xiaoxin , Fensholt Rasmus , Ciais Philippe , Wang Kelin , Liu Siyu , Zhang Wenmin , Mao Chen , Jepsen Martin Rudbeck 
Published: July 2023

AbstractForest expansion has been observed in China over the past decades, but the typically applied coarse resolution satellite data does not reveal spatial details about China’s forest transition. By using three decades of satellite observations at a 30-m spatial resolution, we reveal here the complex spatiotemporal patterns of individual forest stands forming the forest return history of southern China. We calculate forest age, forest densification rates, and annual forest fragmentation and show that the observed forest area surge around 2010 is a result of trees planted after 2000 that formed dense forests about a decade later. We document that old forests in the 1980s were mostly fragmented into scattered patches located on mountain tops, but forests rapidly expanded downhill by 729,540 km2 and alleviated the clear-cut and logging pressure from old forests. Our study provides a detailed documentation of forest densification and expansion for a country that had been largely deforested three decades ago.
Combined Endovascular Treatment of Complex Aortic Pathologies
Authors: Mavioglu Levent , Iscan Hakki Zafer , Askin Goktan , Mola Serkan , Tumer Naim Boran , Unal Ertekin Utku 
Published: July 2023

Abstract
Aim Multisegmented aortic pathologies present challenging issues independent of the treatment chosen. Whether open or endovascular, staged, or simultaneous, every treatment modality has its own pros and cons. We revealed our patients retrospectively with early and midterm results who had simultaneous endovascular thoracic and abdominal aortic repair for thoracic aortic pathologies and infrarenal abdominal aortic aneurysm (iAAA) as a single-center experience.
Materials and Methods Between January 2016 and January 2021, 16 patients were diagnosed with thoracic aortic pathology and iAAA was simultaneously repaired in an endovascular manner. All patients were operated on with the same cardiovascular surgeon team.
Results The average age of the patients were 76.9 ± 6.2 (64–86) years. There was no early mortality. The technical success was 100%. In total, 18 thoracic endografts were deployed in 16 patients for thoracic aortic pathologies. Follow-up period was 21.85 ± 8.96 months, and in the follow-up period, two patients had a secondary intervention. One cardiac and one coronavirus disease 2019 mortality was detected in the follow-up period. There was no aneurysm-related mortality. The postoperative first-year survival was 84.6 ± 10.0.
Conclusion Simultaneous endovascular solution for complex multisegmented aortic pathologies provides a rapid, less-invasive approach with successful early and midterm morbidity, mortality with short intensive care unit period, and length of hospital stay. A combination of endovascular aortic aneurysm repair and thoracic endovascular aortic repair where anatomic suitability exists is a strong alternative over staged and hybrid therapies. Contrast-induced nephropathy, postimplantation syndrome, and spinal cord ischemia should be carefully monitored with this strategy.