bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of social distance on the processing of social evaluation: evidence from brain potentials and neural oscillations
Authors: Hu Xinmu , Zhang Yinling , Mai Xiaoqin 
Published: March 2023

Abstract
Previous research indicates that social distance can influence people’s social evaluations of others. Individuals tend to evaluate intimate others more positively than distant others. The present study investigates the modulating effect of social distance on the time course underlying individuals’ evaluation processes of others using adequate electroencephalography methods. The results reveal that in the initial processing stage, the P2 component is larger when friends are negatively evaluated, whereas this pattern is the opposite for strangers. In the second stage, medial frontal negativity and early mid-frontal theta band activity is enhanced for negative evaluations of friends, whereas this effect is absent in social evaluations of strangers. At the late stage, the P3 is larger for positive evaluations of friends but insensitive to social evaluations of strangers, and the late mid-frontal theta is also modulated by social distance. These findings provide direct and powerful evidence that social distance modulates individuals’ evaluations of others with different levels of intimacy throughout all processing stages.
Evidence of Mpox Virus Infection Among Persons Without Characteristic Lesions or Rash Presenting for First Dose of JYNNEOS Vaccine—District of Columbia, August 2022
Authors: Ogale Yasmin P , Baird Nicolle , Townsend Michael B , Berry Isha , Griffin Isabel , Lee Michelle , Ashley Patrick , Rhodes Trevor , Notigan Tiffany , Wynn Nhien , Kling Chantal , Smith Todd , Priyamvada Lalita , Carson William C , Navarra Terese , Dawson Patrick , Weidle Paul J , Willut Christina , Mangla Anil T , Satheshkumar Panayampalli S , Hutson Christina L , Jackson David A , Waltenburg Michelle A ,   for the DC Mpox Response Project Team, Ahmad Ausaf , Armstrong Jaia , Brake Marie , Bunkley Paige , Callaway Perri , Chakrabarti Ayan K , Folster Jennifer , Forero Catalina , Furness Bruce (Bryce) , Godino Claire , Greenberg Lauren , Guagliardo Sarah Anne J , Jadhao Samadhan , Jordan Teskisha , Kamitani Emiko , Keino Barbara , Kopping Erik , Lee Joo , Lopez Leah , Lowe David , Metz John , Miko Shanna , Mrotz Victoria , Noiman Adi , Partin James , Pearce Melissa Brykailo , Pettus Kevin , Rodriguez Sergio , Sabin Susanna , Santo Loredana , Schrodt Caroline A , Sharma Pankaj , Shelus Victoria , Shi Dallas , Sodeke Olutomi , Springstubb Nora , Stager Christan Halverson , Stewart Roxana Rodriguez , Tang Xiaoling , Tertuliano Moukaram , Timm Logan , Vantucci Casey , Vaughan Gilberto , Wondmeneh Sarah , Yang Yong , Anthony Eric , Argyriou Marie , Ayuk-Takor Leslie , Bryant Miriam , Cherrix Angela , Coleman David , Cunningham Carole , Dastidar Ronit , Dato Olivia , Elnour Azam , Gillani Sarah , Hartley Tracie , Israel Dionnie , Lee Michelle , McCullam Susan , Meh Ie , Notigan Tiffany , Rajamohan Saumya , Rhodes Trevor , Rosado Blanca , Rowse Julia , Shapiro Brandon , Smart Kristen , Staff Michael , Taylor Jaketia , Webb Ricardo , White Rajanique , Widatalla Saria , Wilson Shanice 
Published: March 2023

Abstract
We assessed mpox virus prevalence in blood, pharyngeal, and rectal specimens among persons without characteristic rash presenting for JYNNEOS vaccine. Our data indicate that the utility of risk-based screening for mpox in persons without skin lesions or rash via pharyngeal swabs, rectal swabs, and/or blood is likely limited.
Endovascular repair in type A aortic dissection: Anatomical candidacy for currently manufactured stent grafts and conceptual valve-carrying devices for an Endo-Bentall procedure
Authors: Kern Maximilian , Hauck Sven R , Dachs Theresa-Marie , Haider Lukas , Stelzmüller Marie-Elisabeth , Ehrlich Marek , Loewe Christian , Funovics Martin A 
Published: March 2023

Abstract

OBJECTIVES
Endovascular treatment has been suggested as an alternative for open surgery for type A aortic dissection, but current devices have severe anatomical limitations. This study assesses the computed tomography-based anatomical suitability of currently manufactured stent grafts as well as 2 embodiments of valve-carrying devices.

METHODS
In a retrospective single-centre cohort of 200 consecutive ascending/arch operations between 2009 and 2018, a total of 112 patients with type A aortic dissections were identified and evaluated for endovascular candidacy based on the locations of the entries, the landing zone diameters/lengths and the supra-aortic vessel origins according to the anatomical instructions for use criteria of 6 commercially available (tubular, branched or fenestrated) stent grafts. Two suggested valve-carrying devices with inner branches or fenestrations for the coronary arteries and branches for the supra-aortic vessels were also evaluated.

RESULTS
The anatomical feasibility for commercial stent grafts ranged from 4% to 21%. The main limitations were proximal landing zone diameter (considering oversizing &lt;15%), length due to dilatation and an entry too close to the sinotubular junction. For the valve-carrying conduits, anatomical feasibility was between 31% and 80%, with the main limiting factors being the diameter of the aortic annulus and its distance to the coronary arteries.

CONCLUSIONS
The anatomical applicability of currently manufactured stent grafts for the treatment of type A aortic dissection is limited mainly by the absence of a suitable proximal landing zone in the ascending aorta and might substantially be improved by anchoring in the aortic annulus using a valve-carrying device that uses either fenestrations or branches for the coronary arteries.
Conduction system pacing, a European survey: insights from clinical practice
Authors: Keene Daniel , Anselme Frédéric , Burri Haran , Pérez Óscar Cano , Čurila Karol , Derndorfer Michael , Foley Paul , Gellér László , Glikson Michael , Huybrechts Wim , Jastrzebski Marek , Kaczmarek Krzysztof , Katsouras Grigorios , Lyne Jonathan , Verdú Pablo Peñafiel , Restle Christian , Richter Sergio , Timmer Stefan , Vernooy Kevin , Whinnett Zachary 
Published: March 2023

Abstract

Aims
The field of conduction system pacing (CSP) is evolving, and our aim was to obtain a contemporary picture of European CSP practice.

Methods and results
A survey was devised by a European CSP Expert Group and sent electronically to cardiologists utilizing CSP. A total of 284 physicians were invited to contribute of which 171 physicians (60.2%; 85% electrophysiologists) responded. Most (77%) had experience with both His-bundle pacing (HBP) and left bundle branch area pacing (LBBAP). Pacing indications ranked highest for CSP were atrioventricular block (irrespective of left ventricular ejection fraction) and when coronary sinus lead implantation failed. For patients with left bundle branch block (LBBB) and heart failure (HF), conventional biventricular pacing remained first-line treatment. For most indications, operators preferred LBBAP over HBP as a first-line approach. When HBP was attempted as an initial approach, reasons reported for transitioning to utilizing LBBAP were: (i) high threshold (reported as &gt;2 V at 1 ms), (ii) failure to reverse bundle branch block, or (iii) &gt; 30 min attempting to implant at His-bundle sites. Backup right ventricular lead use for HBP was low (median 20%) and predominated in pace-and-ablate scenarios. Twelve-lead electrocardiogram assessment was deemed highly important during follow-up. This, coupled with limitations from current capture management algorithms, limits remote monitoring for CSP patients.

Conclusions
This survey provides a snapshot of CSP implementation in Europe. Currently, CSP is predominantly used for bradycardia indications. For HF patients with LBBB, most operators reserve CSP for biventricular implant failures. Left bundle branch area pacing ostensibly has practical advantages over HBP and is therefore preferred by many operators. Practical limitations remain, and large randomized clinical trial data are currently lacking.
Hospitalization Rates for Inflammatory Bowel Disease Are Decreasing Over Time: A Population-based Cohort Study
Authors: Buie Michael J , Coward Stephanie , Shaheen Abdel-Aziz , Holroyd-Leduc Jayna , Hracs Lindsay , Ma Christopher , Panaccione Remo , Benchimol Eric I , Bernstein Charles N , Bitton Alain , Otley Anthony R , Jones Jennifer L , Murthy Sanjay K , Ellen Kuenzig M , Peña-Sánchez Juan-Nicolás , Targownik Laura E , Singh Harminder , Avina-Zubieta Antonio , Kaplan Gilaad G 
Published: March 2023

Abstract

Background
Recent advances in the management of inflammatory bowel disease (IBD) striving for new treatment targets may have decreased rates of hospitalization for flares. We compared all-cause, IBD-related, and non-IBD-related hospitalizations while accounting for the rising prevalence of IBD.

Methods
Population-based, administrative health care databases identified all individuals living with IBD in Alberta between fiscal year 2002 and 2018. Hospitalization rates (all-cause, IBD-related, and non-IBD-related) were calculated using the prevalent Alberta IBD population. Hospitalizations were stratified by disease type, age, sex, and metropolitan status. Data were age and sex standardized to the 2019 Canadian population. Log-linear models calculated Average Annual Percentage Change (AAPC) in hospitalization rates with associated 95% confidence intervals (CIs).

Results
From 2002-2003 to 2018-2019, all-cause hospitalization rates decreased from 36.57 to 16.72 per 100 IBD patients (AAPC, −4.18%; 95% CI, −4.69 to −3.66). Inflammatory bowel disease–related hospitalization rate decreased from 26.44 to 9.24 per 100 IBD patients (AAPC, −5.54%; 95% CI, −6.19 to −4.88). Non-IBD-related hospitalization rate decreased from 10.13 to 7.48 per 100 IBD patients (AAPC, −1.82%; 95% CI, −2.14 to −1.49). Those over 80 years old had the greatest all-cause and non-IBD-related hospitalization rates. Temporal trends showing decreasing hospitalization rates were observed across age, sex, IBD type, and metropolitan status.

Conclusions
Hospitalization rates are decreasing for all-cause, IBD-related, and non-IBD-related hospitalizations. Over the past 20 years, the care of IBD has transitioned from hospital-based care to ambulatory-centric IBD management.
Proton pump Inhibitors and Risk of Enteric Infection in Inflammatory Bowel Disease: A Self-controlled Case Series
Authors: Varma Sanskriti , Trudeau Stephen J , Li Jianhua , Freedberg Daniel E 
Published: March 2023

Abstract

Background
We tested whether proton pump inhibitors (PPIs) are associated with enteric infections among those with inflammatory bowel disease (IBD), after adequately accounting for baseline differences between PPI users and nonusers.

Methods
This was a self-controlled case series, with each patient serving as their own control. Ambulatory patients with IBD were included if they were tested for enteric infection by multiplex polymerase chain reaction testing panel (GIPCR) and/or Clostridoides difficile toxin PCR from 2015 to 2019 and received PPIs for some but not all of this period. Rates of enteric infections were compared between the PPI-exposed period vs pre- and post-PPI periods identical in duration to the exposed period. Conditional Poisson regression was used to adjust for time-varying factors.

Results
Two hundred twenty-one IBD patients were included (49% ulcerative colitis, 46% Crohn’s disease, and 5% indeterminate colitis). The median PPI duration was 7 months (interquartile range 4 to 11 months). A total of 25 (11%) patients had a positive GIPCR or C. difficile test in the PPI period, 9 (4%) in the pre-PPI period, and 8 (4%) in the post-PPI period. Observed incidence rates for enteric infections were 2.5, 7.4, and 2.2 per 100 person years for the pre-PPI, PPI, and post-PPI periods, respectively (adjusted incidence rate ratios, 2.8; 95% confidence interval [CI] 1.3-6.0) for PPI vs pre-PPI and 2.9 (95% CI, 1.3-6.4) for PPI vs post-PPI). The adjusted absolute excess risk associated with PPIs was 4.9 infections per 100 person years.

Conclusions
Proton pump inhibitors were associated with a 3-fold increased risk for enteric infection among those with IBD but had a modest absolute risk.
Enhancing the nation’s public health information infrastructure: a report from the ACMI symposium
Authors: Dixon Brian E , Staes Catherine , Acharya Jessica , Allen Katie S , Hartsell Joel , Cullen Theresa , Lenert Leslie , Rucker Donald W , Lehmann Harold 
Published: March 2023

Abstract
The COVID-19 pandemic exposed multiple weaknesses in the nation’s public health system. Therefore, the American College of Medical Informatics selected “Rebuilding the Nation's Public Health Informatics Infrastructure” as the theme for its annual symposium. Experts in biomedical informatics and public health discussed strategies to strengthen the US public health information infrastructure through policy, education, research, and development. This article summarizes policy recommendations for the biomedical informatics community postpandemic. First, the nation must perceive the health data infrastructure to be a matter of national security. The nation must further invest significantly more in its health data infrastructure. Investments should include the education and training of the public health workforce as informaticians in this domain are currently limited. Finally, investments should strengthen and expand health data utilities that increasingly play a critical role in exchanging information across public health and healthcare organizations.
Common Cents: Bank Account Structure and Couples’ Relationship Dynamics
Authors: Olson Jenny G , Rick Scott I , Small Deborah A , Finkel Eli J 
Published: March 2023

Abstract
When a romantic relationship becomes serious, partners often confront a foundational decision about how to organize their personal finances: pool money together or keep things separate? In a six-wave longitudinal experiment, we investigated whether randomly assigning engaged or newlywed couples to merge their money in a joint bank account increases relationship quality over time. Whereas couples assigned to keep their money in separate accounts or to a no-intervention condition exhibited the normative decline in relationship quality across the first 2 years of marriage, couples assigned to merge money in a joint account sustained strong relationship quality throughout. The effect of bank account structure on relationship quality is multiply determined. We examine—and find support for—three potential mechanisms using both experimental and correlational methods: merging finances (1) improves how partners feel about how they handle money, (2) promotes financial goal alignment, and (3) sustains communal norm adherence (e.g., responding to each other’s needs without expectations of reciprocity). While prior research has documented a correlation between financial interdependence and relationship quality, our research offers the first experimental evidence that increasing financial interdependence helps newlyweds preserve stronger relationship quality throughout the newlywed period and potentially beyond.
Effects of midgut bacteria inHyphantria cunea(Lepidoptera: Erebidae) on nuclear polyhedrosis virus andBacillus thuringiensis(Bacillales: Bacillaceae)
Authors: Chen Hongjian , Hao Dejun , Chen Changyu , Sun Yuhang , Yu Xiaohang 
Published: March 2023

AbstractHyphantria cunea Drury (Lepidoptera: Erebidae) is a quarantine pest in China that can cause damage to hundreds of plants. As biological control agents, Nuclear Polyhedrosis Virus (NPV) and Bacillus thuringiensis Berliner (Bacillales: Bacillaceae) (Bt) are commonly used to inhibit the prevalence of H. cunea. To investigate the role of midgut bacteria in the infection of NPV and Bt in H. cunea, we performed a series of tests, including isolating the dominant culturable bacteria in the midgut, eliminating intestinal bacteria, and respectively inoculating the dominant strains with NPV and Bt for bioassay. Two dominant bacteria, Klebsiella oxytoca Lautrop (Enterobacterales: Enterobacteriaceae) and Enterococcus mundtii Collins (Lactobacillales: Enterococcaceae), in the midgut of H. cunea were identified, and a strain of H. cunea larvae without intestinal bacteria was successfully established. In the bioassays of entomopathogen infection, K. oxytoca showed significant synergistic effects with both NPV and Bt on the death of H. cunea. In contrast, E. mundtii played antagonistic effects. This phenomenon may be attributed to the differences in the physico-chemical properties of the two gut bacteria and the alkaline environment required for NPV and Bt to infect the host. It is worth noting that the enhanced insecticidal activity of K. oxytoca on NPV and Bt provides a reference for future biological control of H. cunea by intestinal bacteria.
Estimating the efficiency gain of covariate-adjusted analyses in future clinical trials using external data
Authors: Li Xiudi , Li Sijia , Luedtke Alex 
Published: March 2023

Abstract
We present a framework for using existing external data to identify and estimate the relative efficiency of a covariate-adjusted estimator compared to an unadjusted estimator in a future randomized trial. Under conditions, these relative efficiencies approximate the ratio of sample sizes needed to achieve a desired power. We develop semiparametrically efficient estimators of the relative efficiencies for several treatment effect estimands of interest with either fully or partially observed outcomes, allowing for the application of flexible statistical learning tools to estimate the nuisance functions. We propose an analytic Wald-type confidence interval and a double bootstrap scheme for statistical inference. We demonstrate the performance of the proposed methods through simulation studies and apply these methods to estimate the efficiency gain of covariate adjustment in Covid-19 therapeutic trials.
The LMC impact on the kinematics of the Milky Way satellites: clues from the running solar apex
Authors: Makarov Dmitry , Khoperskov Sergey , Makarov Danila , Makarova Lidia , Libeskind Noam , Salomon Jean-Baptiste 
Published: March 2023

ABSTRACT
Dwarf galaxies provide a unique opportunity for studying the evolution of the Milky Way (MW) and the Local Group as a whole. Analysing the running solar apex based on the kinematics of the MW satellites, we discovered an unexpected behaviour of the dipole term of the radial velocity distribution as a function of the Galactocentric distance. The nearby satellites (&lt;100 kpc) have a bulk motion with an amplitude of 140–230 km s−1, while the more distant ones show an isotropic distribution of the radial velocities. Such strong solar apex variations cannot be explained by the net rotation of the satellites, as it would require an enormously high rotation rate (≈970 km s−1). If we exclude the Large and Magellanic Clouds (LMC) and its most closely related members from our sample, this does not suppress the bulk motion of the nearby satellites strongly enough. Nevertheless, we have demonstrated that the observed peculiar kinematics of the MW satellites can be explained by a perturbation caused by the first infall of the LMC. First, we ‘undone’ the effect of the perturbation by integrating the orbits of the MW satellites backwards (forwards) with (without) massive LMC. It appears that the present-day peculiar enhancement of the solar apex in the inner halo is diminished the most in the case of 2 × 1011 M⊙ LMC. Next, in self-consistent high-resolution N-body simulations of the MW–LMC interaction, we found that the solar apex shows the observed behaviour only for the halo particles with substantial angular momentum, comparable to that of the MW satellites.
The mass of our observable Universe
Authors: Gaztañaga Enrique 
Published: March 2023

ABSTRACT
The standard cosmological model Lambda Cold Dark Matter (LCDM) assumes a global expanding space–time of infinite extent around us. But such idea is inconsistent with the observed cosmic acceleration unless we advocate for the existence of a mysterious dark energy (DE) or a cosmological constant (Λ). Here, we argue instead that our Universe has a very large but finite regular mass M, without the need to invoke DE or Λ. A system with a finite mass M has a finite gravitational radius rS = 2GM. When M is contained within rS, this is a black hole (BH). Nothing from inside can escape outside rS, which becomes a boundary for the inside dynamics. In the limit where there is nothing else outside, the inside corresponds then to a local isolated universe. Such boundary condition is equivalent to a Λ term: $\Lambda =3/r_\mathrm{ S}^2$. We can therefore interpret cosmic acceleration as a measurement of the gravitational radius of our Universe, rS, with a mass M ≃ 6 × 1022 M⊙. Such BH Universe is observationally very similar to the LCDM, except for the lack of the largest scale perturbations, which are bounded by rS.
The association of urinary epidermal growth factors with ADPKD disease severity and progression
Authors: Harskamp Laura R , Perez-Gomez Maria Vanessa , Heida Judith E , Engels Gerwin E , van Goor Harry , van den Heuvel Marius C , Streets Andrew J , Ong Albert C M , Ortiz Alberto , Gansevoort Ron T ,   the DIPAK Consortium, Drenth J P H , de Fijter J W , van Gastel M D A , Meijer E , Losekoot M , Peters D J M , Visser F W , Wetzels J , Zietse R 
Published: March 2023

ABSTRACT

Background
The epidermal growth factor receptor (EGFR) pathway is involved in kidney tissue repair and growth. Preclinical interventional data and scarce human data have suggested a role for this pathway in the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD), while other data have suggested that its activation is causally linked to repair of damaged kidney tissue. We hypothesize that urinary EGFR ligands, as a reflection of EGFR activity, are associated with kidney function decline in ADPKD in the context of tissue repair following injury, and as the disease progresses as a sign of insufficient repair.

Methods
In the present study, we measured the EGFR ligands, EGF and heparin binding-EGF (HB-EGF), in 24-h urine samples of 301 ADPKD patients and 72 age- and sex-matched living kidney donors to dissect the role of the EGFR pathway in ADPKD. During a median follow-up of 2.5 years, the association of urinary EGFR ligand excretion with annual change in estimated glomerular filtration rate (eGFR) and height-adjusted total kidney volume in ADPKD patients was analyzed using mixed-models methods, and the expression of three closely related EGFR family receptors in ADPKD kidney tissue was investigated by immunohistochemistry. Additionally, the effect of reducing renal mass (after kidney donation), was assessed to investigate whether urinary EGF matches this reduction and thus reflects the amount of remaining healthy kidney tissue.

Results
At baseline, urinary HB-EGF did not differ between ADPKD patients and healthy controls (P = .6), whereas a lower urinary EGF excretion was observed in ADPKD patients [18.6 (11.8–27.8)] compared with healthy controls [51.0 (34.9–65.4) μg/24 h, P &lt; .001]. Urinary EGF was positively associated with baseline eGFR (R = 0.54, P &lt; .001) and a lower EGF was strongly associated with a more rapid GFR decline, even when adjusted for ADPKD severity markers (β = 1.96, P &lt; .001), whereas HB-EGF was not. Expression of the EGFR, but not other EGFR-related receptors, was observed in renal cysts but was absent in non-ADPKD kidney tissue. Finally, unilateral nephrectomy resulted in a decrease of 46.4 (–63.3 to –17.6) % in urinary EGF excretion, alongside a decrease of 35.2 ± 7.2% in eGFR and 36.8 ± 6.9% in measured GFR (mGFR), whereas maximal mGFR (measured after dopamine induced hyperperfusion) decreased by 46.1 ± 7.8% (all P &lt; .001).

Conclusions
Our data suggest that lower urinary EGF excretion may be a valuable novel predictor for kidney function decline in patients with ADPKD.