bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chat-GPT: Opportunities and Challenges in Child Mental Healthcare
Authors: Imran Nazish , Hashmi Aateqa , Imran Ahad 
Published: June 2023

Mental health in children and young people is a global public health concern. With the increasing prevalence of mental illnesses and a significant treatment gap, Mental Health in children and adolescents is now a global public health concern. The development and extensive research in the field of Artificial Intelligence(AI) for healthcare has been quite promising. The emergence of AI based alternatives could be a viable solution for reducing mental health treatment gap for people belonging to low and middle income countries. Development of Chatbots like ChatGPT which is trained, using large amount of textual data from the internet, can revolutionize child and adolescent mental healthcare by acting as an effective assisting tool but a lot of caution is required for its safe and responsible use in times to come.
doi: https://doi.org/10.12669/pjms.39.4.8118
How to cite this: Imran N, Hashmi A, Imran A. Chat-GPT: Opportunities and Challenges in Child Mental Healthcare. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.8118
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Prevention and Mitigation of Rural Higher Education Dropout in Colombia: A Dynamic Performance Management Approach.
Authors: Guzman Rincón Alfredo , Barragán Sandra , Cosenz Federico , Cala Vitery Favio 
Published: June 2023

Background: Dropout in higher education is a socio-educational phenomenon that has the scope to limit the benefits of education as well as to widen social disparities. For this reason, governments have implemented various public policies for its prevention and mitigation. However, in rural populations, such policies have proven to be ineffective. The aim of this paper is to simulate public policy scenarios for the treatment of school dropout in rural higher education in Colombia from a Dynamic Performance Management approach. Methodology: To achieve the aim, a parameterised simulation model was designed with data from Colombian state entities in rural higher education. Five simulations were carried out. The analysis of the results was carried out using descriptive statistics and comparison of means using the Wilcoxon Sign Rank statistic. Results: The adoption of such an approach based on simulations suggests that policies to expand the coverage of educational credits and financial support, as well as the addition of a family income subsidy, allow for a reduction in the number of dropouts. Conclusions: A dynamic, data-driven approach can be effective in preventing and mitigating dropout in these areas. It also highlights the importance of identifying the key factors contributing to dropout. The results also suggest that government policies can have a significant impact on school retention in rural areas.
The impact of a revision arthroplasty network on patient outcomes
Authors: Bloch Benjamin V. , Matar Hosam E. , Berber Reshid , Gray William K. , Briggs Timothy W. R. , James Peter J. , Manktelow Andrew R. J. 
Published: June 2023

AimsRevision total knee arthroplasty (rTKA) and revision total hip arthroplasty (rTHA) are complex procedures with higher rates of re-revision, complications, and mortality compared to primary TKA and THA. We report the effects of the establishment of a revision arthroplasty network (the East Midlands Specialist Orthopaedic Network; EMSON) on outcomes of rTKA and rTHA.MethodsThe revision arthroplasty network was established in January 2015 and covered five hospitals in the Nottinghamshire and Lincolnshire areas of the East Midlands of England. This comprises a collaborative weekly multidisciplinary meeting where upcoming rTKA and rTHA procedures are discussed, and a plan agreed. Using the Hospital Episode Statistics database, revision procedures carried out between April 2011 and March 2018 (allowing two-year follow-up) from the five network hospitals were compared to all other hospitals in England. Age, sex, and mean Hospital Frailty Risk scores were used as covariates. The primary outcome was re-revision surgery within one year of the index revision. Secondary outcomes were re-revision surgery within two years, any complication within one and two years, and median length of hospital stay.ResultsA total of 57,621 rTHA and 33,828 rTKA procedures were performed across England, of which 1,485 (2.6%) and 1,028 (3.0%), respectively, were conducted within the network. Re-revision rates within one year for rTHA were 7.3% and 6.0%, and for rTKA were 11.6% and 7.4% pre- and postintervention, respectively, within the network. This compares to a pre-to-post change from 7.4% to 6.8% for rTHA and from 11.7% to 9.7% for rTKA for the rest of England. In comparative interrupted time-series analysis for rTKA there was a significant immediate improvement in one-year re-revision rates for the revision network compared to the rest of England (p = 0.024), but no significant change for rTHA (p = 0.504). For the secondary outcomes studied, there was a significant improvement in trend for one- and two-year complication rates for rTHA for the revision network compared to the rest of England.ConclusionRe-revision rates for rTKA and complication rates for rTHA improved significantly at one and two years with the introduction of a revision arthroplasty network, when compared to the rest of England. Most of the outcomes studied improved to a greater extent in the network hospitals compared to the rest of England when comparing the pre- and postintervention periods.Cite this article: Bone Joint J 2023;105-B(6):641–648.
Impact of bisoprolol and amlodipine on cardiopulmonary responses and symptoms during exercise in patients with chronic obstructive pulmonary disease
Authors: Lan Chou-Chin , Hsieh Po-Chun , Tzeng I-Shiang , Yang Mei-Chen , Wu Chih-Wei , Su Wen-Lin , Wu Yao-Kuang 
Published: June 2023

Background
Patients with chronic obstructive pulmonary disease (COPD) often have exercise intolerance. The prevalence of hypertension in COPD patients ranges from 39–51%, and β-blockers and amlodipine are commonly used drugs for these patients.

Objectives
We aimed to study the impact of β-blockers and amlodipine on cardiopulmonary responses during exercise.

Methods
A total 81 patients with COPD were included and the patients underwent spirometry, cardiopulmonary exercise tests, and symptoms questionnaires.

Results
There were 14 patients who took bisoprolol and 67 patients who did not. Patients with COPD taking ß-blockers had lower blood oxygen concentration (SpO2) and more leg fatigue at peak exercise but similar exercise capacity as compared with patients not taking bisoprolol. There were 18 patients treated with amlodipine and 63 patients without amlodipine. Patients taking amlodipine had higher body weight, lower blood pressure at rest, and lower respiratory rates during peak exercise than those not taking amlodipine. Other cardiopulmonary parameters, such as workload, oxygen consumption at peak exercise, tidal volume at rest or exercise, cardiac index at rest or exercise were not significantly different between patients with or without bisoprolol or amlodipine. Smoking status did not differ between patients with or without bisoprolol or amlodipine.

Conclusions
COPD is often accompanied by hypertension, and β-blockers and amlodipine are commonly used antihypertensive drugs for these patients. Patients with COPD taking bisoprolol had lower SpO2 and more leg fatigue during peak exercise. Patients taking amlodipine had lower respiratory rates during exercise than those not taking amlodipine. Exercise capacity, tidal volume, and cardiac index during exercise were similar between patients with and without bisoprolol or amlodipine.
Art that Moves: The Works of Len Lye, Roger Horrocks (2015)
Authors: Wright Andrea 
Published: June 2023

Review of: Art that Moves: The Works of Len Lye, Roger Horrocks (2015)
Auckland: Auckland University Press, 257 pp.,
ISBN 978 1 86940 422 2 (pbk), NZ$79.99

The Long Dream of Waking: New Perspectives on Len Lye, Paul Brobbel, Wystan Curnow and Roger Horrocks (eds) (2017)
Christchurch: Canterbury University Press, 224 pp.,
ISBN 978 1 92714 596 8 (pbk), NZ$49.99
On Line Dispute Resolution na Administração Pública Brasileira: Estudo a partir de um Mapeamento Sistemático
Authors: Silva Filho Antônio Sabino da , Silva João Carlos Sedraz 
Published: June 2023

Diante do advento da Administração Pública Consensual (ou dialógica), percebe-se, no âmbito da Administração Pública Brasileira, uma vertiginosa valorização de técnicas alternativas de resolução de conflitos. Diante da relevância do tema proposto, o presente trabalho tem como objetivo avaliar a utilização da Online Dispute Resolution (ODR) no âmbito da denominada Administração Pública Consensual, para o tratamento de conflitos que envolvam entes e órgãos públicos. Para alcançar esse objetivo, empreendeu-se um estudo de natureza aplicada, seguindo um percurso metodológico envolvendo um mapeamento sistemático sobre experiências da adoção de ODR pela Administração Pública. Observou-se que, mesmo com farta legislação sobre o tema, e em que pesem as plataformas públicas já existentes em em plena funcionalidade, a utilização da ODR pela Administração Pública ainda é incipiente, o que denota a necessidade de investimento público na referida tecnologia. Espera-se, com este trabalho, contribuir para uma maior eficiência da gestão pública.
De-emphasizing Statistical Significance
Authors: Mitton Todd 
Published: June 2023

Abstract
Persistent and difficult methodological issues, such as those highlighted in Ohlson (2025. Empirical accounting seminars: Elephants in the room. Accounting, Economics, and Law: A Convivium 15, 1–8), undermine confidence in the results of empirical studies. Many of these issues relate to the efforts of researchers to defend the statistical significance of their results. However, the seemingly endless combination of methodologies that can be employed make statistical significance a somewhat illusory concept. A more productive approach would be to place greater emphasis on the economic significance of empirical results.
Neue Bibliotheken in alten Häusern – Ein Reisebericht zu Bibliotheken in den Niederlanden
Authors: Göring Eva , Momirovski Vlatko , Stenert Felix 
Published: June 2023

Zusammenfassung
Glückliche Niederlande, du hast es besser! – Inspiration, Vorstellungskraft und Partizipation sind die Hauptmerkmale des Bibliothekswesens in den Niederlanden. Dort findet der bibliothekarische Geist eine Heimat in architektonischen Meisterwerken wie einer industriellen Lokomotivfabrik, einem alten Postgebäude oder gar einer Kathedrale. Was die Bibliotheken des Nachbarlandes ausmacht, was dort anders und was manches Mal besser läuft, wird im folgenden subjektiven Reisebericht erläutert.
Two new compounds from leaves of Capparis dongvanensis (Sy, B. H. Quang & D. V. Hai) and inhibition activities
Authors: Van Khang Pham , Hiep Hoang Phu , Trung Tu Quang 
Published: June 2023

Abstract
In continuation of the research, the phytochemical investigation of Capparis dongvanensis (Sy, B. H. Quang & D. V. Hai) (Capparaceae). In this work, we described the isolation and identification of two novel polycyclic compounds Capparisone A (1) and Capparisone B (2). The structures of these compounds were determined based on NMR spectral data and mass spectrometry. Furthermore, we evaluated the inhibitory activities of isolated compounds from C. dongvanensis leaves against five cancer cell lines, the results showed that isolated compounds exhibited good activities on four cancer cell lines. Otherwise, two isolated compounds 1 and 2 and EA extract also exhibited the anti-oxidant activity in the DPPH free radical scavenging assay.
Ptolemaios, Caligula und die fremdeabolla – Neue Überlegungen zum Ende des letzten mauretanischen Königs
Authors: Decker Christopher 
Published: June 2023

ZusammenfassungDer Tod des Ptolemaios von Mauretanien im frühen 1. Jahrhundert n. Chr. erscheint auch heute noch rätselhaft. In dieser Untersuchung soll daher neues Licht auf ein vieldiskutiertes Thema geworfen werden. Dabei wird insbesondere eine Passage in Suetons Schrift über den römischen Kaiser Caligula in den Blick genommen, der für den Tod des Ptolomaios verantwortlich gewesen sein soll. Dort wird berichtet, dass Caligula den mauretanischen König habe ermorden lassen, da dieser in einer purpurnenabollain Rom erschienen sein und somit den Kaiser öffentlich brüskiert haben soll. In der Analyse der schriftlichen Quellen wird deutlich, dass es sich bei derabollaum eine typische Tracht hellenistisch geprägter Herrscher handelte, die von der römischen Gesellschaft als fremd konnotiert wurde. Die prestigeträchtige Farbe des Purpurs stellte eine zusätzliche Komponente einer traditionellen monarchischen Selbstdarstellung dar, die von Ptolemaios als König von Mauretanien auch so zu erwarten gewesen sein muss. Doch zeigt es sich, dass das Auftreten des Ptolemaios von Caligula vor dem Hintergrund der Spannungen der Gaetulicus-Lepidus-Verschwörung und der selbst gewählten Herrschaftskonzeption desprinceps – einer expressiven Repräsentation des eigenen Ranges – missverstanden wurde. Dies führte schließlich zur drastischen Reaktion des Kaisers.
Cassava starch nanocomposite films reinforced with nanocellulose
Authors: Asmawi Nazrin , Ilyas R. A. , Mohd Roslim Muhammad Huzaifah , Rajeshkumar L. , Abotbina W. , Syafri Edi , Jumaidin Ridhwan , Syafiq R. , Rafiqah S. A. , Ridwan R. , Jusoh Suriani Mat , Mohamed Yusoff Mohd Zuhri 
Published: June 2023

Abstract
Recent researchers are keen on developing alternative bioplastic materials from renewable and eco-friendly sources to replace the materials obtained from crude oil and other petroleum-based sources. The measures for these replacements have been made continuously to create a sustainable future for the forthcoming generations. Researchers are focusing on bio-based alternatives due to their numerous benefits, including biodegradability, biocompatibility, nontoxicity, and structural flexibility. The main problem on the current bio-based material such as poly lactic acid, poly butylene succinate and poly L lactide, polyhydroxybuturate, and polyhydroxyalkalonates is the cost of production. Compare with cassava starch, the cost is much cheaper around 0.32 $/kg compare with other bio-based will cost around 1.2–2.4 $/kg. Conversion of biomass into useful materials has been the order of the day, as it reduces the cost of inventory and aims to develop a nature-derived material. The development of nanocomposites from biological sources has progressively experimented with the researchers and the deriving of polysaccharides such as starch, cellulose, and glycogen has aided the development of nanobiocomposites. Corn starch has been the dominant bioplastic material derived out of corn which can handle a variety of reinforcements and render a biocomposite material with better and enhanced properties. Cassava starch is the most economic and cheap polysaccharide derived from the cassava plant and has a greater potential to act as biopolymer material for the development of biocomposites. The development of cassava starch-based biocomposite film was widely used for a wide range of applications mainly for food packaging applications. This review focuses on the extraction, preparation, and properties of cassava starch from cassava plants. The properties of the cassava starch and its composites were also comprehensively dealt with. The development of biocomposite films based on cassava starch for food packaging applications has been reviewed along with the challenges associated with it.
Is particle size reduction linked to drug efficacy: an overview into nano initiatives in pharmaceuticals
Authors: Sher Mujahid , Zahoor Muhammad , Shah Syed Waqas Ali , Khan Farhat Ali 
Published: June 2023

Abstract
Poor aqueous solubility results in ineffective drug dissolution and a reduced bioavailability. The poor bioavailability may render even effective medications therapeutically ineffective. Therefore, improving water solubility is necessary in order to enhance drug dissolution and availability at the action site. Drug solubility has been increased using conventional methods, but these methods have many drawbacks, including inconsistent particle size and difficulty in reproducing. Nanotechnology can enable drug targeting and can also offer protection to drugs against degradation. Phytochemicals have some unbelievable benefits when it comes to disease treatment. The integration of phytotherapy and nanotechnology at clinical level will boost pharmacological response and favorable clinical results for the ailing population. The given review is an overview of what may be the consequences, if a drug is poor water soluble and current approaches that further improve these drugs solubility. While such process of solubilization of drugs is also explained. It explains how nanoparticles of drugs, nanocarriers, and lipid-based nano-systems, can be utilized to meet the challenges and which of these methods do already prevail in the market. Finally, it is drawing a line of demarcation and making comparisons between the crude drug formulations and those with enhanced solubility.
Measurement of Pavement 3D Texture Using the Binocular Reconstruction Algorithm Improved by Moving Laser Line Constraint
Authors: Wang Yuanyuan , Ren Xiaofeng , Huang Zhongwen , Liu Yanyan 
Published: June 2023

Abstract
For such a specific object as asphalt pavement with inconspicuous feature points, the traditional image vision algorithm has limited effect on its texture measurement. In order to realize the high-resolution, high-precision, and convenient detection of three-dimensional (3D) pavement texture while better serving traffic safety, the traditional binocular reconstruction technology was improved in this study threefold. First, the improved binocular reconstruction test system and the measurement accuracy evaluation device were manufactured to realize the reconstruction of the 3D texture and the true point-to-point evaluation of measurement accuracy. Second, the global scanning constraint posed by a moving laser line was introduced to shoot video images, which formed numerous mandatory constraints and improved the matching accuracy. Last, the centroid enhanced subregion segmentation algorithm was proposed to complete stereo matching under global scanning constraint. Results show that the binocular reconstruction algorithm improved by moving a laser line constraint under a centroid enhanced subregion segmentation matching mode can significantly improve the accuracy in the measurement of asphalt pavement 3D texture. Ultimately, the test results can meet the precision requirement of micro-texture.
Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer
Authors: Couto Joana Pinto , Vulin Milica , Jehanno Charly , Coissieux Marie‐May , Hamelin Baptiste , Schmidt Alexander , Ivanek Robert , Sethi Atul , Bräutigam Konstantin , Frei Anja L , Hager Carolina , Manivannan Madhuri , Gómez‐Miragaya Jorge , Obradović Milan MS , Varga Zsuzsanna , Koelzer Viktor H , Mertz Kirsten D , Bentires‐Alj Mohamed 
Published: June 2023

AbstractMetastatic colonization of distant organs accounts for over 90% of deaths related to solid cancers, yet the molecular determinants of metastasis remain poorly understood. Here, we unveil a mechanism of colonization in the aggressive basal‐like subtype of breast cancer that is driven by the NAD+ metabolic enzyme nicotinamide N‐methyltransferase (NNMT). We demonstrate that NNMT imprints a basal genetic program into cancer cells, enhancing their plasticity. In line, NNMT expression is associated with poor clinical outcomes in patients with breast cancer. Accordingly, ablation of NNMT dramatically suppresses metastasis formation in pre‐clinical mouse models. Mechanistically, NNMT depletion results in a methyl overflow that increases histone H3K9 trimethylation (H3K9me3) and DNA methylation at the promoters of PR/SET Domain‐5 (PRDM5) and extracellular matrix‐related genes. PRDM5 emerged in this study as a pro‐metastatic gene acting via induction of cancer‐cell intrinsic transcription of collagens. Depletion of PRDM5 in tumor cells decreases COL1A1 deposition and impairs metastatic colonization of the lungs. These findings reveal a critical activity of the NNMT‐PRDM5‐COL1A1 axis for cancer cell plasticity and metastasis in basal‐like breast cancer.
ДОСЛІДЖЕННЯ ВПЛИВУ ОБЛАДНАННЯ НА РІВЕНЬ ТРАВМАТИЗМУ ТА ПРОФЕСІЙНИХ ЗАХВОРЮВАНЬ
Authors: Перетяка Сергій Миколайович , Палагута Віталій Михайлович , Котенко Олег Васильович , Васильченко Олександра Євгенівна 
Published: June 2023

В роботі проаналізовано статистику і причини нещасних випадків на підприємствах України. Визначено, які недоліки обладнання викликають професійні захворювання. Сформульовані напрями удосконалення обладнання, які потрібно враховувати при розробці і модернізації обладнання.
Встановлено, що головними причинами нещасних випадків на вітчизняних виробництвах є організаційні. Усунення цих причин не потребує проведення «промислової революції» та значних фінансових витрат. Достатньо розуміння роботодавцем і керівниками підрозділів, що не створення безпечних і комфортних умов для працівників призведе до неочікуваних збитків. Тому потрібна мотивація для керуючої ланки сумлінно дотримуватися існуючого законодавства з охорони праці. Найбільш «болючими» причинами для українських реалій є ігнорування інструкцій з безпеки праці, неналежне здійснення посадових обов’язків, невідповідність знань і вмінь працівників та керівників посадам, які вони займають.
Вчасні і ретельні інструктажі, навчання безпечним методам роботи (які не потребують фінансових витрат) дають можливість підвищити рівень знань працівників. Це дозволить знизити ймовірність травматизму на виробництві, а також забезпечить впевненість співробітників у своїх діях, що відобразиться на продуктивності їх праці. Працівник, який задоволений умовами праці завжди зацікавлений у конкурентоздатності підприємства. На підприємствах, де створені безпечні та комфортні умови праці відсутня плинність кадрів. Зменшення контролю зі сторони держави призвело до того, що обов’язкові вимоги вітчизняного законодавства з охорони праці не виконуються роботодавцями.
Після пандемії і війни вітчизняні підприємства відчують справжній «голод» на працівників в результаті демографічної ситуації та трудової міграції. Роботодавці, які не зрозуміють, що заходи з охорони праці є необхідністю – будуть нести втрати, які безпосередньо вплинуть на їх прибутки. Дисципліна «Охорона праці» поступово зникає з навчальних планів бакалаврів, що неминуче ще більше погіршить ситуацію з умовами праці на українських підприємствах у майбутньому.