bluuebunny/crossref_metadata_2025_split huggingface dataset:
HDAC3‐mediated lncRNA ZFAS1 inhibited IL‐13‐induced secretion of proinflammatory cytokines in nasal epithelial cells by regulating the miR‐7‐5p/SIRT1 pathway
Authors: Zhan Jiabin , Li Rui , Ye Yi , Zheng Jing , Wang Gang , Wu Jinli , Wei Xin , Zeng Min 
Published: September 2023

AbstractAllergic rhinitis (AR) is a disease that is difficult to cure and accompanies the patient's life. Proinflammatory cytokines (GM‑CSF and eotaxin) and MUC5AC are key mediators promoting AR progression. Herein, the function of lncRNA ZFAS1 in AR was investigated. Nasal epithelial cells (NECs) were subjected to 50 ng/mL IL‐13 for 24 h to construct an AR cell model. The mRNA and protein expressions were assessed using qRT‐PCR and western blot. The levels of GM‑CSF, eotaxin, IL‐1β, IL‐6, TNF‐α and MUC5AC in cell supernatant were examined by ELISA. The binding relationships between HDAC3, ZFAS1, miR‐7‐5p and SIRT1 were analysed using dual luciferase reporter or ChIP assays. Herein, our results displayed that ZFAS1 and SIRT1 were lowly expressed in AR, while miR‐7‐5p and HDAC3 were highly expressed. Functional experiments displayed that ZFAS1 overexpression suppressed IL‐13‐induced proinflammatory cytokines and mucin production in NECs. The highly expressed HDAC3 in AR inhibited ZFAS1 expression by binding with ZFAS1 promoter. In addition, our experiments revealed that ZFAS1 targeted miR‐7‐5p, and miR‐7‐5p targeted SIRT1. As expected, miR‐7‐5p overexpression or SIRT1 silencing abrogated ZFAS1 upregulation's repression on IL‐13‐induced proinflammatory cytokines and MUC5AC secretory levels in NECs. ZFAS1 suppressed proinflammatory cytokines, inflammatory cytokines, and MUC5AC secretory levels in AR by regulating the miR‐7‐5p/SIRT1 axis. Thus, our work suggested that ZFAS1 might serve as a novel target for AR treatment and prevention.
Mechanism of oxygen vacancies migration in BaTiO3‐BiMeO3: Experimental investigations and first principles studies
Authors: Liu Wan‐Qi , Wang Qian , Lu Hong‐Ting , Zhao Xian , Wang Chun‐Ming 
Published: September 2023

AbstractBaTiO3‐based compounds are recognized as the most common dielectric material used in multilayer ceramic capacitors (MLCCs), among which, BaTiO3‐BiMeO3 is extensively investigated to improve the thermal stability and extend the service life of MLCCs, which are strongly dependent on the conductivity at high temperatures. Despite numerous efforts have been made, the mechanism of oxygen vacancy conduction, which makes the major contributions to the conduction mechanism of BaTiO3‐based compounds at high temperatures below 450°C, is still unclear. In this paper, BaTiO3, 0.88BaTiO3‐0.12Bi(Zn2/3Nb1/3)O3, 0.88BaTiO3‐0.12Bi(Mg2/3Nb1/3)O3, and 0.88BaTiO3‐0.12Bi(Mg2/3Ta1/3)O3 ceramics have been prepared by solid‐state reaction method, and their electrical and dielectric properties have been studied in detail. Meanwhile, first principles were applied to study the mechanisms of the increase of electrical resistivity and the decrease of dielectric loss. It is found that B‐site dopants (Zn, Mg, Nb, and Ta) are effective in reducing the conductivity by inhibiting the migration of oxygen vacancies, which is a kinetics process with an increase of energy barrier. Notably, the greater ability of Zn to inhibit oxygen vacancies migration is a combination of thermodynamics (a strong ability to trap oxygen vacancies) and kinetics (an effect of block the migrating defects in the lattice). This work reveals a new insight into the mechanism of oxygen vacancies migration in BaTiO3‐based perovskite compounds, which makes BaTiO3‐BiMeO3 prospective in designing efficient and durable medium‐temperature solid oxide capacitor devices.
Screening for depression: Psychometric properties of the German version of the Glasgow depression scale for people with a learning disability (individual and carer version)
Authors: Müller Katrin , Helmes Almut , Kleischmann Annika , Graser Johannes , Bengel Jürgen 
Published: September 2023

AbstractBackgroundAdults with intellectual disabilities should participate in the diagnostics of their mental health. The Glasgow Depression Scale for people with a Learning Disability (GDS‐LD) and its Carer Supplement (GDS‐CS) were translated into German and tested.MethodsInternal consistency, criterion validity and inter‐test reliability were tested in 64 adults with borderline, mild or moderate intellectual disabilities and their carers. Convergent validity was analysed in 57 adults without intellectual disabilities.ResultsInternal consistency was good (α = 0.81) for GDS‐LD and acceptable (α = 0.72) for GDS‐CS. The GDS‐LD did not differentiate between groups with and without depression. The GDS‐CS significantly differentiated between these groups. Convergent validity of the GDS‐LD was high. The correlation of GDS‐LD and GDS‐CS was non‐significant.ConclusionsIn its present form the German version of the GDS‐LD does not meet the psychometric properties to be used in clinical practice. This leads to the broader question, how to measure depression in people with learning disabilities with the knowledge of the fallibility of existing measures when utilised with this clinical cohort. Also, future studies need to investigate the role of self‐rating.
Ex‐military CEOs and readability of financial reports
Authors: Jha Anand , Panta Humnath , Sarkar Salil K. 
Published: September 2023

AbstractIn this study, we examine the effect of ex‐military Chief Executive Officers (CEO)s on the readability of 10‐Ks. Using the Bog Index as a measure of readability, we find that firms run by ex‐military CEOs have much more readable financial reports, mainly because of the words used in these financial reports. Ex‐military CEOs also have a moderating effect—we find that their leadership lessens the adverse effects of loss and business complexity on the 10‐K's readability. These results are consistent with the view that ex‐military CEOs resist the temptation to obfuscate negative news and may communicate complexity in operations more clearly. Overall, our findings indicate a possible behavioral explanation for why some firms have more readable annual reports.
Volatiles of the trap crop sunflowers: Effects on the behaviour of adult female Conogethes punctiferalis moths
Authors: Zhou Jia , Chen Li‐Lin , Zhu Yu‐Tong , Siemann Evan , Wan Nian‐Feng 
Published: September 2023

AbstractSunflowers (Helianthus annuus) are potential trap crops to attract the yellow peach moth (Conogethes punctiferalis) in orchards but the volatile compounds released from sunflowers and their effects on C. punctiferalis behaviour are not clear. Here we used solid phase micro‐extraction to collect volatiles released from flower disks of sunflowers, identified them by gas chromatography–mass spectrometry, and examined the attractiveness of some of the compounds to mated female adult C. punctiferalis moths in Y‐tube olfactometer choice tests. We detected nine volatile compounds (α‐Pinene, β‐Phellandrene, Camphene, β‐Pinene, 3‐Carene, D‐Limonene, Eucalyptol, γ‐Terpinen, and Valencene) with consistently large peak areas for α‐Pinene and β‐Phellandrene. Among tested volatiles, both α‐Pinene and β‐Phellandrene were attractive to C. punctiferalis in olfactometer tests but this was only significant for higher concentrations of β‐Phellandrene. This suggests that β‐Phellandrene may promote C. punctiferalis oviposition on sunflower disks. This study provides insights into volatile chemical mediated responses of insect herbivores to trap crops.
Familial critical consciousness socialization: How key family theories can expand racial‐ethnic socialization research among Asian American families
Authors: Saavedra J. Abigail , Matriano Ronae , Yoo Hyung Chol , White Rebecca M. B. 
Published: September 2023

AbstractAs systems of oppression (e.g., racism) become more evident in public consciousness, Asian American families are grappling with critical discussions about social justice and oppression. To define and explore these increasingly common conversations, we propose critical consciousness socialization as an important construct for socialization research among Asian American families. Critical consciousness socialization is the transmission of knowledge about, skills for, and behavioral orientations toward analyzing and challenging systems of oppression in the interest of social justice. This article applies theories in the developmental and family sciences (Phenomenological Variant of Ecological Systems Theory and Family Systems Theory) to demonstrate future research directions for critical consciousness socialization among Asian American families. Given research suggesting that families are purveyors of information about social justice and power, research on critical consciousness socialization is important to explore the role of the family system in advancing—and actively participating in—movements towards social justice.
Copper induces neuron‐sparing, ferredoxin 1‐independent astrocyte toxicity mediated by oxidative stress
Authors: Gale Jenna R. , Hartnett‐Scott Karen , Ross Madeline M. , Rosenberg Paul A. , Aizenman Elias 
Published: September 2023

AbstractCopper is an essential enzyme cofactor in oxidative metabolism, anti‐oxidant defenses, and neurotransmitter synthesis. However, intracellular copper, when improperly buffered, can also lead to cell death. Given the growing interest in the use of copper in the presence of the ionophore elesclomol (CuES) for the treatment of gliomas, we investigated the effect of this compound on the surround parenchyma—namely neurons and astrocytes in vitro. Here, we show that astrocytes were highly sensitive to CuES toxicity while neurons were surprisingly resistant, a vulnerability profile that is opposite of what has been described for zinc and other toxins. Bolstering these findings, a human astrocytic cell line was similarly sensitive to CuES. Modifications of cellular metabolic pathways implicated in cuproptosis, a form of copper‐regulated cell death, such as inhibition of mitochondrial respiration or knock‐down of ferredoxin 1 (FDX1), did not block CuES toxicity to astrocytes. CuES toxicity was also unaffected by inhibitors of apoptosis, necrosis or ferroptosis. However, we did detect the presence of lipid peroxidation products in CuES‐treated astrocytes, indicating that oxidative stress is a mediator of CuES‐induced glial toxicity. Indeed, treatment with anti‐oxidants mitigated CuES‐induced cell death in astrocytes indicating that oxidative stress is a mediator of CuES‐induced glial toxicity. Lastly, prior induction of metallothioneins 1 and 2 in astrocytes with zinc plus pyrithione was strikingly protective against CuES toxicity. As neurons express high levels of metallothioneins basally, these results may partially account for their resistance to CuES toxicity. These results demonstrate a unique toxic response to copper in glial cells which contrasts with the cell selectivity profile of zinc, another biologically relevant metal.image
Blaming the victim or structural conditioning? COVID‐19, obesity and the neoliberal diet
Authors: Otero Gerardo 
Published: September 2023

AbstractThe energy‐dense part of the neoliberal diet and obesity made for an explosive combination upon the arrival of the COVID‐19 pandemic. Energy‐dense foods lie at the root of comorbidities associated with complications of the COVID‐19 pandemic: overweight, obesity, diabetes, hypertension and so forth. Multiple medical studies have demonstrated the causal impact of overweight and obesity on more severe or lethal infections. Focusing on the case of Mexico, I will show that inequality strongly conditions what people can eat, so the issue is not simply a matter of personal choice or responsibility. My argument is twofold: (1) Mexico enjoyed its own ‘traditional’ diets through the mid‐1980s, which included widely accessible fruits and vegetables. But (2) the neoliberal turn in the form of trade liberalization and deepening inequality caused a substantial reshaping of the diet in favour of energy‐dense foods with lower nutritional value. The energy‐dense segment of ‘the neoliberal diet’ has turned a large portion of Mexicans into a vulnerable population. But this is a class‐differentiated diet with its healthy and nutritious components increasingly less accessible to the working classes. Recovering healthy diets in Mexico will require the recuperation of food sovereignty through the regeneration of its countryside and its peasantry. Agroecological methods of food production will also be needed to alleviate the climate change emergency.
Emerging functions and applications of exosomes in oral squamous cell carcinoma
Authors: Qie Yingchun , Sun Xia , Yang Yongqiang , Yan Tao 
Published: September 2023

AbstractOral squamous cell carcinoma is the most common phenotype in pathology, which accounts for 80% of all oral cancers. The therapeutic methods of oral squamous cell carcinoma include surgical excision, chemotherapy, and radiotherapy. Whereas, the high recurrence rate and poor prognosis lead to a 5‐year survival rate less than 50%. In order to explore more therapeutic strategies of oral squamous cell carcinoma, the relevant risk factors, mechanisms, and diagnostics are widely detected. The various exosome‐mediated biological effects on the development of oral squamous cell carcinoma have drawn lots of attention. Exosomes, a kind of extracellular vesicles secreted from host cells and transferred to other cells, show great potential in the regulations of tumorigenesis, progression, and metastasis on oral squamous cell carcinoma. Moreover, some studies reported that the exosomes could interact with tumor microenvironment and be applied to diagnosis or therapy of oral squamous cell carcinoma. In this work, we will summarize the frontier studies of exosomes in the tumor growth, tumor‐associated angiogenesis, invasion, and metastasis of oral squamous cell carcinoma, and then probe the current biological functions and applications of exosomes and exosome‐derived materials for the therapeutic strategies of oral squamous cell carcinoma, which would help us to update the understanding of exosomes in oral squamous cell carcinoma.
Performance of the caries diagnosis feature of intraoral scanners and near‐infrared imaging technology—A narrative review
Authors: Lin Wei‐Shao , Alfaraj Amal , Lippert Frank , Yang Chao‐Chieh 
Published: September 2023

AbstractPurposeTo describe and discuss the benefits and drawbacks of various dental caries diagnostic techniques, including the use of intraoral scanners for caries diagnosis based on near‐infrared imaging (NIR) technology.Material and MethodsA MEDLINE search from 1980–2023 focused on dental caries diagnostic techniques, emphasizing intraoral scanners using NIR technology. Alternative caries detection methods were also evaluated for their advantages and limitations, enabling a comparison with NIR. The review included traditional caries tools, the latest detection methods, and NIR's role in intraoral scanners, drawing from case reports and both in vivo and in vitro studies. Keywords like “caries detection,” “intraoral scanners,” and “Near Infrared Imaging (NIRI)” guided the search. After screening titles and abstracts for relevance, full texts with valuable insights were thoroughly analyzed. The data was grouped into three: traditional diagnostics, advanced digital methods, and intraoral scanner‐based detection.ResultsThis comprehensive narrative review described and discussed the current state of dental caries diagnostic methods, given the insufficient number of clinical investigations suitable for a systematic review. Traditional caries diagnosis techniques have shown variable accuracy dependent on a dentist's experience and the potential over‐removal of healthy tooth structures. Intraoral scanners have emerged as a novel caries detection method, because of their integration of NIR technology. Various studies have confirmed the efficacy of NIR in detecting interproximal caries and in the early diagnosis of non‐cavitated caries. Specifically, intraoral scanners have demonstrated promising results, proving comparable to established diagnostic methods like bitewing radiography. Nevertheless, while the integration of NIR into intraoral scanners seems promising, the technology still faces challenges, notably its accuracy in detecting secondary and subgingival cavities. However, with anticipated integrations of AI, NIR in intraoral scanners could revolutionize early caries detection.ConclusionsIntraoral scanners with NIR technology offer non‐destructive imaging, real‐time lesion visuals, and enhanced patient communication. Although comparable to bitewing radiography in some studies, a universally accepted diagnostic tool is lacking. Future research should compare them with existing methods, focusing on clinical outcomes, cost‐effectiveness, and patient acceptance.
Use of serum osmolality to identify heart disease stage in dogs and relationship to mathematical chloride correction
Authors: Daly Edward J. , Harris Autumn N. , Adin Darcy B. 
Published: September 2023

AbstractBackgroundHeart failure‐associated hypochloremia can be depletional from diuretics or dilutional from water retention. Serum osmolality reflects water balance but has not been evaluated in dogs with heart disease.HypothesisTo determine if serum osmolality is related to heart disease stage and amount of mathematical correction of serum chloride (Cl−) concentrations in healthy dogs and dogs with myxomatous mitral valve degeneration (MMVD).AnimalsSeventy‐seven dogs (20 healthy, 25 Stage B MMVD, 32 Stage C/D MMVD).MethodsSerum Cl− concentrations were mathematically corrected. Osmolality was calculated (calOsm) and directly measured by freezing point depression (dmOsm) and compared by Bland‐Altman analysis. Biochemical variables and osmolality were compared among healthy, Stage B, and Stage C/D dogs. Correlations were explored between osmolality and biochemical variables. Median and range are presented. P < .05 was considered significant.ResultsThe calOsm was different among groups (P = .003), with Stage B (310 mOsm/kg; 306, 316) and C/D dogs (312 mOsm/kg; 308, 319) having higher calOsm than healthy dogs (305 mOsm/kg; 302, 308). Osmolality methods were moderately correlated (P < .0001, rs = .46) but with proportional bias and poor agreement. The amount of Cl− correction was negatively correlated with calOsm (P < .0001, rs = −.78) and dmOsm (P = .004, rs = −.33). Serum bicarbonate concentration was negatively correlated with Cl− (P < .0001, rs = −.67).Conclusions and Clinical ImportanceDogs with Stage B and Stage C/D heart disease had higher calOsm than healthy dogs. Osmolality was inversely related to the amount of Cl− correction, which supports its use in assessing relative body water content. Poor agreement between calOsm and dmOsm prevents methodological interchange.
Number of patients with interstitial cystitis/bladder pain syndrome seen before versus during the COVID‐19 pandemic at an academic, urban, multisite urogynecology practice
Authors: Markert Tahireh , Courtepatte Alexa , Farah Subrina , Miranne Jeannine M. 
Published: September 2023

AbstractObjectivesLittle is known about the impact of the COVID‐19 pandemic on interstitial cystitis/bladder pain syndrome (IC/BPS). We aim to compare the number of newly diagnosed IC/BPS cases and number of patients with flares prior to and during the pandemic.MethodsWe conducted a retrospective cohort study of women ≥18 years who were diagnosed with or treated for IC/BPS between March 2019 and March 2021 at an academic, urban, multisite urogynecology practice. The primary outcome was the number of IC/BPS cases from March 1, 2019 to February 29, 2020 (pre‐pandemic) compared with March 1, 2020 to February 28, 2021 (during pandemic). The secondary outcome was the number of patients with flares during those same two time periods. Demographic and clinical characteristics were compared using nonparametric tests and interrupted time series (ITS) was used to evaluate our outcomes of interest. p‐Value <.05 was considered significant.ResultsFifty‐four women (4.87% of new patients) were diagnosed with IC/BPS during the pandemic compared with 40 women pre‐pandemic (4.05% of new patients). The median age was 35.0. Seventy‐two percent were premenopausal, 75% sexually active, and 31% had anxiety, and there were no significant differences between groups. Although the number of patients newly diagnosed with IC/BPS was higher during the pandemic, the diagnosis rates between time periods were not statistically different. Thirty‐five patients experienced flares during the pandemic compared with 49 patients the year prior (p = .43). This difference was also not statistically significant on ITS analysis.ConclusionsAlthough more patients were diagnosed with IC/BPS during versus before the pandemic, the difference in diagnosis rates was not different between these periods.
Patterns of genetic differentiation imply distinct phylogeographic history of the mosquito species Anopheles messeae and Anopheles daciae in Eurasia
Authors: Brusentsov Ilya I. , Gordeev Mikhail I. , Yurchenko Andrey A. , Karagodin Dimitriy A. , Moskaev Anton V. , Hodge James M. , Burlak Vladimir A. , Artemov Gleb N. , Sibataev Anuarbek K. , Becker Norbert , Sharakhov Igor V. , Baricheva Elina M. , Sharakhova Maria V. 
Published: September 2023

AbstractDetailed knowledge of phylogeography is important for control of mosquito species involved in the transmission of human infectious diseases. Anopheles messeae is a geographically widespread and genetically diverse dominant vector of malaria in Eurasia. A closely related species, An. daciae, was originally distinguished from An. messeae based on five nucleotide substitutions in its ribosomal DNA (rDNA). However, the patterns of phylogeographic history of these species in Eurasia remain poorly understood. Here, using internal transcribed spacer 2 (ITS2) of rDNA and karyotyping for the species identification we determined the composition of five Anopheles species in 28 locations in Eurasia. Based on the frequencies of 11 polymorphic chromosomal inversions used as genetic markers, a large‐scale population genetics analysis was performed of 1932 mosquitoes identified as An. messeae, An. daciae and their hybrids. The largest genetic differences between the species were detected in the X sex chromosome suggesting a potential involvement of this chromosome in speciation. The frequencies of autosomal inversions in the same locations differed by 13%–45% between the species demonstrating a restricted gene flow between the species. Overall, An. messeae was identified as a diverse species with a more complex population structure than An. daciae. The clinal gradients in frequencies of chromosomal inversions were determined in both species implicating their possible involvement in climate adaptations. The frequencies of hybrids were low ~1% in northern Europe but high up to 50% in south‐eastern populations. Thus, our study revealed critical differences in patterns of phylogeographic history between An. messeae and An. daciae in Eurasia. This knowledge will help to predict the potential of the malaria transmission in the northern territories of the continent.