bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognosis of Prothrombin Activity in Patients with Heart Failure
Authors: Hu Sutian , Zeng Weijie , Zhang Yitao , Chen Zhichong , Cheng Shiyao , Ouyang Mao , Chen Lin , Xue Jiaojie 
Published: June 2023

Abstract
Background: Patients with heart failure frequently exhibit coagulation dysfunction and abnormal liver function. Prothrombin activity (PTA) serves as a sensitive indicator to assess these irregularities. Thus, our objective was to assess the prognostic significance of PTA in risk assessment for heart failure.
Method: The database is sourced from this paper1. In this retrospective cohort study, it recruited 2008 patients with heart failure admitted to Zigong Fourth People’s Hospital between December 2016 to June 2019. Demographic data, medical history, Charlson score at admission, Glasgow coma score(GCS) and their first blood samples after admission were all collected, including biochemical electrolytes, coagulation function, liver and kidney function, jaundice routine, blood analysis, and blood gas analysis. These patients were followed up for six months. The primary end point of follow-up was all-cause death, and the secondary end point was readmission within six months.
Results: In this retrospective cohort study, the all-cause mortality rate was 2.1% (n=42) at six months. Significant differences were observed between the fatal and non-fatal groups in terms of PTA and the proportion of patients with grade IV cardiac function. PTA demonstrated promising potential as a predictor of all-cause mortality, with an optimal threshold of 60.94 (p<0.001). Kaplan-Meier analysis demonstrated lower survival and higher re-hospitalization rates in patients with PTA≤60.94. Multivariate analyses identified creatinine, D-dimer, AST, GCS, and PTA≤60.94[OR3.990(1.551-10.263), P=0.004] as independent predictors of mortality. For re-hospitalization, PTA≤60.94 [OR1.814(1.436-2.292), P＜0.001] were remain an independent predictor.
Conclusion: Prothrombin activity provides powerful prognostic information for patients with heart failure.
Bond Strength of Zirconia Ceramics to Dentin Using Two Resin Cements: Influence of Dentin Conditioning
Authors: El-Khbeer Ahmed Abd , Ghorab Sayed , Attia Ahmed 
Published: June 2023

Abstract
Background
Dentin adhesion has difficult challenge compared to enamel adhesion. The purpose of the current study was to assess the impact of different dentin conditioning methods and two different resin cements on bond strength of zirconia ceramics to dentin.
Methods
A total of 64 zirconia discs were fabricated using CAD/CAM technology according to the desired dimensions (8mm diameter ×3mm thickness). A total of 64molars mounted in plastic rings with acrylic resin were prepared by exposing flat coronal dentin surfaces by removing the occlusal enamel and superficial dentin. The prepared molars were divided into 4 main groups (n = 16) according to dentin surface treatment; Dentin left as cutted, treated with EDTA, treated with Polyacrylic Acid (PAA), treated with self-etch adhesive. Each main group was subdivided into 2 subgroups (n = 8) according to luting cement used. One of the subgroups, zirconia discs were bonded to conditioned dentin surface using adhesive resin cement (VITA ADIVA® F-CEM). The other subgroup was bonded using self-adhesive resin cement (Calibra®Universal). After bonding, all specimens were stored in water bath at 37⁰C for 6 months followed by 10.000 thermal cycles. After artificial aging, all bonded specimens underwent shear bond strength testing using universal testing machine. The data was parametric and normally distributed. Two-way ANOVA was used to test significant difference in shear stress between cements and between surface treatments followed by post hoc Tukey test for correction of p value resulted from multiple comparisons. P is significant if < 0.05 at confidence interval 95%.
Results
There was a significant difference in shear bond strength between surface treatments. The highest shear bond strength was reported with Self-etch adhesive, followed by PAA, then EDTA surface treatments, and the lowest shear bond strength was reported with as cutted dentin. Also,There was a significant difference between each two surface treatments except between PAA and EDTA for adhesive resin cement group.
Conclusion
Define dentin surface treatment with self etch adhesive is recommended before bonding zirconia restoration overall the conditioning materials, followed by PAA and EDTA. Specially with self-adhesive resin cement (Calibra universal cement).
Fatty liver is associated with significant liver inflammation but does not increase fibrosis burden in Chronic HBV infection
Authors: Dai Yi-Ning , Xu Cheng-Fu , Pan Hong-Ying , Chen Mei-Juan , Yu Chao-Hui 
Published: June 2023

AbstractBackground:Concurrent non-alcoholic fatty liver disease (NAFLD) is common in patients with chronic HBV infection. But the impact of fatty liver on the histologic progression of HBV infection remains controversial.Methods:Consecutive HBV-infected patients who underwent liver biopsy between 2016 and 2021 were included. Alcohol consumption and other types of viral hepatitis were excluded. All biopsies were scored for grading and staging by Scheuer’s score, and the steatosis was scored as an estimate of the percentage of liver parenchyma replaced by fat. Logistic regression analyses were applied to assess the associated factors for significant liver inflammation (G≥2) and significant fibrosis (S≥2).Results:Among the871 HBV-infected patients,hepatic steatosis was prevalent in 255 patients (29.28%). Significant liver inflammation was present in 461 patients (52.93%), while significant fibrosis was observed in 527 patients (60.51%). Fatty liver was an independent risk factor for significant liver inflammation (OR: 2.117, 95% CI: 1.500-2.988), but it could not predict significant fibrosis. Especially, in HBV-infected patients with persistent normal ALT (immune tolerant and inactive carrier phase), the presence of significant liver inflammation was higher in NAFLD than those without NAFLD. However, in HBeAg-negative chronic hepatitis B, the presence of significant liver fibrosis was lower in NAFLD group than those with non-NAFLD. We developed a predictive model for significant liver inflammation with the area under receiver operating characteristic curve (AUROC) of 0.825, and a model for significant fibrosis with the AUROC of 0.760.Conclusions:NAFLD is independently associated with significant liver inflammation, but does not increase the fibrosis severity in HBV-infected patients. The influence of NAFLD on the degree of liver inflammation and fibrosis is different in distinct clinical phases of chronic HBV infection.
An Evidence Update to Explore Molecular Targets and Protective Mechanisms of Apigenin against Abdominal Aortic Aneurysms Based on Network Pharmacology and Experimental Validation
Authors: LI DONGYU , WANG LEI , JIANG BO , MIAO YUXI , LI XUAN 
Published: June 2023

AbstractAbdominal aortic aneurysms(AAA) is a life-threatening disease and the incidence of AAA is still on the rise in recent years. Numerous studies suggest dietary moderate consumption of polyphenol exert beneficial effects on cardiovascular disease. Apigenin(API) is a promising dietary polyphenol and possesses potent beneficial effects on our body. Although our previous study revealed protective effects of API on experimental AAA formation, up till now few studies were carried out to further investigate its involved molecular mechanisms. In the present study, network pharmacology combined molecular docking and experimental validation was used to explore API-related therapeutic targets and mechanisms in the treatment of AAA. Firstly, we collected 202 API-related therapeutic targets and 2475 AAA-related pathogenetic targets. After removing duplicates, a total of 68 potential therapeutic targets were obtained. Moreover, 5 targets with high degree including TNF, ACTB, INS, JUN and MMP9 were identified as core targets of API for treating AAA. In addition, functional enrichment analysis indicated API exerted pharmacological effects in AAA by affecting versatile mechanisms, including apoptosis, inflammation, blood fluid dynamics and immune modulation. Molecular docking results further supported that API had strong affinity with the above core targets. Furthermore, protein level of core targets and related pathways were evaluated in a Cacl2-induced AAA model by using western blot and immunohistochemistry. The experimental validation results demonstrated that API significantly attenuated phosphorylation of JUN and protein level of predicted core targets. Taken together, based on network pharmacological and experimental validation, our study systematically explored associated-core targets and potential therapeutic pathways of API for AAA treatment, which could supply valuable insights and theoretical basis for AAA treatment.
Comparison between T-piece or CPAP and pressure support ventilation in spontaneous breathing trials: a systematic review and meta-analysis
Authors: Wang Yiyun , Jia Lu , Wang Pufeng , Cao Min , Liu Siqi , Huo Runbo , Xie Jianfeng 
Published: June 2023

Abstract
Background
The ideal time to wean off of a ventilator has been predicted using the spontaneous breathing trial (SBT). Which trial ought to be chosen with preference is still debatable. Among critically sick patients receiving mechanical ventilation (MV) our goal was to evaluate typical SBT modalities such as pressure support ventilation (PSV), continuous positive airway pressure (CPAP), and T-piece.
Methods
We searched the PubMed, Cochrane, Embase, Web of Science database for RCTs from inception to the 30th of Nov. 2022. We included RCTs involving adult patients (> 18 years) who underwent at least two different SBT methods. Primary outcome was extubation. Secondary outcomes were reintubation, mechanical ventilation duration, intensive care unit (ICU) mortality, and hospital mortality, intensive care unit (ICU) length of stay and hospital length of stay. Statistical analysis was conducted by using RevMan 5.4 and trial sequence analysis (TSA). Results were expressed as risk ratio (RR) or mean difference (MD) with accompanying 95% confidence interval (CI).
Results
Twenty-one RCTs comprising 4636 patients are included. The results of this meta-analysis showed that there was a significant difference in the successful extubation rate between the T-piece or CPAP group and PSV group (risk ratio [RR] = 0.93; 95% CI, 0.90–0.96; P < 0.00001; Chi2 = 7.86; I2 = 0%). In addition, there was statistically difference in the hospital mortality between 2 groups (risk ratio [RR] = 1.23; 95% CI, 1.01–1.49; P = 0.04; ChI2 = 3.07; I2 = 0%). Compared with the PS group, the T-piece or CPAP group showed no significant difference in other secondary outcomes. Further subgroup analysis found that the duration of mechanical ventilation appeared to be shorter in the PSV group than in the T-piece group in patients with difficult weaning.
Conclusions
The prognostic power of T-piece, CPAP, and PSV as SBTs for effective extubation in critically ill patients is seen as being equivalent. PSV has the potential to increase the success rate of patient extubation when compared to T-piece or CPAP. In addition, the PSV group appeared to have an advantage over the other group in lowering hospital mortality and cutting the time those patients with difficult weaning.
Clinical Impact of Fluoropolymer-Based Drug-eluting Stent Thrombosis in Femoropopliteal Artery Occlusive Lesions
Authors: Shimizu Haruna , Kobayashi Taira , Okazaki Takanobu , Mochizuki Shingo , Sato Tomoyasu , Maeda Kazuki , Emura Shogo , Arai Yasunori , Kato Yuichi , Takahashi Shinya 
Published: June 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Durability and Microstructure Analysis of Cupola Replacement in Fine Aggregate and Reinforced Graphene Oxide
Authors: Patil Ashwini , Kapure Harshada 
Published: June 2023

Abstract

Aiming to compare the microstructure and mechanical characteristics of conventional concrete with graphene-reinforced concrete with 0.05% wt and partially replacing cupola slag as a fine aggregate concrete using a scanning electron microscope and various mechanical methods to identify the effect of GO and copula on concrete. Through extensive experimental testing, the impacts of the GO concentration, the water content ratio, and cupola on the mechanical characteristics of GO and cupola composites made of cement were fully examined. The test findings reveal that concrete's compressive and split tensile strengths are surprisingly increased when compared with convectional concrete while using a consistent w/c ratio and an ideal 30% cupola as replacements of fine aggregate. According to studies on the composition-microstructure-strength connection, adding GO could improve the macroscopic properties of cement-based composites by improving the microstructure of the cement's hydration products, lowering crystal size, and producing a denser and more regular network structure. The filling impact, hydrating effect, and polymerization impact of GO may be maximised with the right combination of the water to carbon proportions and GO concentration..
Maternal satisfaction with shared decision-making among women who underwent caesarean section in Sidama region South Ethiopia: Facility-based cross-sectional study
Authors: Wondimu Melkamu Getu , Sisay Binyam Demisse , Aga Meseret Birhanu , Alemu Belete 
Published: June 2023

Abstract
Background:- Maternal satisfaction with shared decision-making is one of the most important aspects of the healthcare delivery system that aims at providing quality services that meet the expectations of the mothers. In Ethiopia have been limited studies of maternal satisfaction with shared decision-making. Therefore, the study aims to explore maternal satisfaction with involvement in decision-making to identify the key influencing factors.
Methods:- Facility-based cross-sectional study was conducted from June 01/2022-July 01/2022 in Sidama region Public Hospitals, among women who underwent a caesarean section. The total sample size was 416. A simple random sampling technique was used to select the study participant. Bivariate and multivariable binary logistic regression was carried out. The strength of the association of outcome and predictor variables was presented by crude and adjusted odds ratio at a 95% confidence interval. Variables with a p-value of < 0.05 were considered statistically significant.
Result:-In this study, among total study participants, 174 (41.8%) respondents were satisfied with shared decision-making during a caesarean section. Urban residence [AOR 1.7 (95% CI: 1.02, 2.7)], explaining the procedure in the mother tongue [AOR 2.4 (95% CI: 1.5, 3.9)], provision adequate information [AOR 3.2 (95% CI: 1.87, 5.3)] and spent sufficient time with care providers [AOR 1.8(95% CI: 1.08, 2.9)]were positively associated with maternal satisfaction.
Conclusion and recommendation:-Maternal satisfaction with shared decision-making are relatively low. Therefore, healthcare providers need to do more to increase mothers' satisfaction with collaborative decision-making during the procedure.
Influence of The Embedded Participant on Learners’ Performance during High-Fidelity Simulation Sessions in Healthcare
Authors: Koca Ayça , Schlatter Sophie , Delas Quentin , Denoyel Lucas , Lehot Jean-Jacques , Lilot Marc , Rimmelé Thomas 
Published: June 2023

Abstract
Introduction
The embedded participant (EP) plays a key role during a full scale/high-fidelity simulation (HFS) session. He/she is expected to guide the learner towards the achievement of the educational objectives of the scenario. However, his/her influence on learners’ performance stands undetermined and this effect remains briefly addressed in the literature. This study primarily aims to assess whether the EP could influence on the performance of the learner during a HFS scenario. The secondary aim was to establish an inventory of the EP practices in France.
Methods
This retrospective study was conducted in an academic Health Simulation Centre (France). Anaesthesia and critical care residents in postgraduate years 1 to 5 who were scheduled for their HFS sessions during the 2016 to 2021 academic years were included. Two investigators independently evaluated the resident performance regarding both technical and non-technical skills from video recordings. In addition, a nationwide survey was sent out by email through the networks of the Francophone Healthcare Simulation Society (SoFraSimS, Société Francophone de Simulation en Santé) to collect information on EP practices in French-speaking Simulation centres.
Results
From a total of 344 HFS videos analysed, a cohort of 19 experienced EPs was identified. The EPs had an influence on the technical and non-technical performances of the learners. The 147 responses to the survey showed that predefined rules of EP good practice existed in only 36% of the simulation centres and 65% of respondents believed that specific EP training would be justified.
Conclusion
EP can exert an influence on the performance of the learners during HFS. For acting as an EP, a great variability of practices and a lack of training are reported by professionals working in simulation centres. These results suggest that more attention must be paid to EP training and attitudes during simulation, especially if summative simulations are extensively developed.
Beam-steering of Dielectric Flat Lens Nanoantenna with Elliptical Patch based on Antenna Displacement for Optical Wireless Applications
Authors: Helmy Fatma , Ibrahim Ibrahim , Saleh Amany 
Published: June 2023

Abstract
In this paper, the switched-beam nanoantenna (NA) concept is introduced with a theoretical design of an inhomogeneous dielectric flat lens modelled with different materials to steer and enhance the radiation in a particular direction based on shifting the illuminator element. Firstly, the design of hybrid plasmonic NA is introduced and analyzed considering different silicon patch shapes such as rectangular, circular, hexagonal, and elliptical shapes. The elliptical patch NA achieves a gain of up to 10.7 dBi and a return loss of -14.41 dB. Then the design of a gradient-index dielectric flat lens with the NA is introduced to improve the antenna performance by increasing the directivity and consequently decreasing the beam-width. Furthermore, the beam-steering capabilities by displacement of the NA according to different feeding points along the X and Y-direction. By using the gradient-index dielectric flat lens, the gain is increased to 18.4 dBi with an improvement in the return loss reach to -19.15 dB compared with traditional NA. In addition, the beam-steering capabilities were achieved with a range ± 60° × ±55° with acceptable average antenna gain, side-lobe levels, and half power beam-width of 16.5 dBi, -12.3 dB and 13.6° respectively.
Adhesion is a risk factor for postoperative recurrence of spontaneous pneumothorax
Authors: Motono Nozomu , Mizoguchi Takaki , Ishikawa Masahito , Iwai Shun , Iijima Yoshihito , Uramoto Hidetaka 
Published: June 2023

Abstract
Background
Several risk factors for postoperative recurrence of spontaneous pneumothorax have been reported, but the identified risk factors differed among studies.
Methods
A total of 272 spontaneous pneumothorax patients were enrolled in this retrospective study, and the risk factors for postoperative recurrence were evaluated.
Results
Among the patients, more than 80% with ipsilateral postoperative recurrence relapsed within 3 years and more than 80% with contralateral postoperative recurrence relapsed within 4 years. Univariate analyses showed that age < 25 years (p < 0.01), Brinkman index = 0 (p = 0.03), intraoperative adhesion (p = 0.04), and upward lung volume > 75.8% (p = 0.03) were significant risk factors for ipsilateral postoperative recurrence. Age < 25 years (odds ratio: 10.41; 95% confidence interval: 1.42–76.15; p = 0.02) and intraoperative adhesion (odds ratio: 10.18; 95% confidence interval: 2.39–43.22; p < 0.01) were identified as risk factors for ipsilateral postoperative recurrence in a multivariate analysis.
Conclusions
The present findings suggest that young age and intraoperative adhesion are risk factors for postoperative recurrence of spontaneous pneumothorax. For such patients, additional intraoperative procedures, such as covering with polyglycolic acid sheet for primary spontaneous pneumothorax and covering with absorbable oxidized cellulose with 50% glucose solution, may be required to reduce postoperative recurrence.
Trial registration:
The Institutional Review Board of Kanazawa Medical University approved the protocol of this retrospective study (approval number: I800), and written informed consent was obtained from all patients
Gendered Pathways to Socioemotional Competencies in Very Young Children
Authors: Liu Qin , Huang Jing , Caldwell Melissa Pearl , Cheung Sum Kwing , Cheung Him , Siu Carrey 
Published: June 2023

Abstract
Parent-child and teacher-child relationships are important correlates of children’s socioemotional competencies. However, less is known about whether these relationship qualities play a role in shaping the early development of socioemotional competencies in very young children attending childcare group settings. The current study aims to address this gap and to explore how child gender may moderate these associations. The participants included 395 children (203 girls; Mage = 21.18 months, SD = 10.26 months) enrolled in childcare centres, along with their parents and teachers. Parents reported on children’s socioemotional competencies as well as their relationship quality with children, and teachers reported on their relationship quality with children. Multiple group structural equation modelling (SEM) was used to analyse the results. The findings showed that both parent-child and teacher-child closeness were positively associated with children’s social competence, whereas teacher-child closeness was negatively associated with children’s anxiety behaviour. Furthermore, gender differences were observed in these associations. Teacher-child closeness was a significant predictor of social competence exclusively among girls, while parent-child closeness was a significant predictor of anxiety behaviours solely among boys. Findings suggested that parents and teachers may consider implementing tailored strategies when interacting with boys and girls who experience socioemotional difficulties in group settings in the early years.
Use of an AMCA-modified specific DNA aptamer for rapid detection of Vibrio vulnificus
Authors: Cai Shumei , Lian Xia , Liu Yichu , Wang Shuiliang , Huang Aiwen , Zhao Meng , zhang shenghang 
Published: June 2023

Abstract
Vibrio vulnificus (V.V) can cause serious infections in humans. The traditional method to culture this pathogen is time-consuming and has a high failure rate. Common pathogenic microorganisms present in the seawater of the Fujian Sea area were collected, cultured, and identified. The samples were found to contain mainly Staphylococcus aureus (S.A), Escherichia coli (E. Coli), Pseudomonas aeruginosa (P.A), V.V, Vibrio alginolyticus (V.A), Vibrio parahaemolyticus (V.P). A DNA aptamer was constructed with an aminomethylcoumarin acetate (AMCA) modification on the 5’ ends, to target V.V and generate a fluorescent signal upon contact. Using this custom aptamer, we were able to detect the presence of V.V through fluorescence microscopy. Based on the pathogenic microorganisms we identified in our samples, the aptamer was screened and optimized for rapid detection of V.V infections. We used modified aptamers to detect V.V from 50 bacteria. In this experiment, the sensitivity, specificity, positive predictive value and negative predictive value of the modified aptamer to detect V.V were 100%[95%CI(0.39,1)], 93.4%[95%CI(0.81,0.98)], 57%[95%CI(0.20,0.88), 100%[95%CI(0.89,1) respectively. We are able to rapidly detect V.V specimens via a fluorescence reaction within 30 minutes. Our results showed that this modified DNA aptamer have potential diagnosis of V.V infection. We need more research to explore the application of aptamers in pathogen infection.