bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collect to destroy. The annihilation of German and Polish Jewish research libraries
Authors: Cieślińska-Lobkowicz Nawojka 
Published: July 2023

Jewish research libraries emerged in the wake of the Jewish Enlightenment and the Jewish studies initiated subsequently. They formed the foundation of this new field of knowledge, rapidly developing by Jewish scholars. The subject of this article is the history of three German libraries – one in Breslau and two in Berlin – and four libraries in the Second Polish Republic: one in Warsaw, two in Vilnius, and one in Lublin. After introducing these Jewish research libraries from their foundation to Hitler’s rise to power (1933) and, respectively, to the outbreak of war, the author describes their fate during the years of Nazi rule. Closed, confiscated, destroyed, looted, deported, used in perverse ways – all seven ceased to exist. The subject of the text section of the article is the postwar distribution of the volumes surviving from these Jewish libraries. The article closes with reflections on the study of the provenance of the survived books, dispersed in collections on several continents, as a means of saving the libraries from which they originated from oblivion.
فاعلية اتخاذ القرار لدى مدربي اندية الدوري العراقي الممتاز بالكرة الطائرة من وجهة نظر اللاعبين
Authors: Lect. Ali Shamkhi Jabbar  
Published: July 2023

تكمن اهمية البحث في الحصول على مقياس مقنن لاتخاذ القرار لمعرفة مستويات اتخاذ القرار التي تتمتع بها العينة الامر الذي قد يسهم في اتخاذ القرارات المناسبة والصحيحة اثناء التدريب والمنافسة ووضع نتائج الدراسة امام الباحثون والمدربين من اجل الاستفادة من هذه النتائج وتطبيها على الفرق الرياضية ميدانيا , وتبرز مشكلة البحث الحالي الى تسليط الضوء على طبيعة اتخاذ القرارات ومستوياتها لدى مدربي الدوري العراقي الممتاز بالكرة الطائرة لتحديد نقاط القوة في اتخاذ القرار وتعزيزها ومقاط الضعف ومعالجتها وفق أسس علمية رصينة ووضعها في متناول المدربين لمساعدتهم على اتخاذ قرارات سليمة مبنية على الفهم الايجابي للمواقف المختلفة , ولأهمية هذه المتغيرات وجب دراستها بشكل علمي, ومن الخطوات الرئيسية لذلك هو ايجاد مقياس دقيق
ويهدف البحث الى:
1- بناء مقياس اتخاذ القرار لمدربي الدوري العراقي الممتاز بالكرة الطائرة للموسم الرياضي
2021-2022
2- التعرف على مستوى اتخاذ القرار لمدربي الدوري العراقي الممتاز بالكرة الطائرة للموسم الرياضي 2021-2022
3- التعرف على المستويات المعيارية لاتخاذ القرار لمدربي الدوري العراقي الممتاز بالكرة الطائرة للموسم الرياضي 2021-2022
PENTINGNYA MELAKUKAN PEMANASAN DAN PENDINGINAN PADA SAAT MELAKUKAN AKTIVITAS OLAHRAGA PADA SISWA PONDOK IMBS PEKAJANGAN PEKALONGAN
Authors: Salsabila Marshanda Salsabila 
Published: July 2023

The Importance Of Warning Down When Carrying Out Sports Activities For Student At The Pekajangan Pekalongan Islamic Boarding School.
One of the community service activities is socialization. Providing education on the importance of heating and cooling before and after carrying out sports activities for IMBS Pekajangan Pekalongan Islamic Boarding School students. The students of the IMBS Pekajangan Pekalongan Islamic boarding school were very enthusiastic, this activity was held before the 1st semester long holiday, with high support from the IMBS Islamic boarding school, 6 of us students with provisions from the campus, thank God, socialized it smoothly and with joy.
The socialization of physical fitness education was carried out on Friday 30 December 2022 at 13.00, the place in the IMBS Pekajangan Pekalongan hall. In the student team, which consists of 6 people, each of them has their own duties, including as a presenter about the order of providing heating and cooling, there is a section that organizes student lines and there is also a photo documenter.
In this activity students see and practice carefully how the presenter gives educational material the importance of warming up and cooling down before and after doing sports activities. From this we can conclude that there is very good and conducive communication from the presenters and students which students can understand.

Keywords: Heating, cooling, physical fitness.
PROVIDING EDUCATION TO STUDENTS AT THE DARUL ILMI BATANG Islamic Boarding School THE IMPORTANCE OF SPORT WARMING FOR THE ELDERLY
Authors: Khafis Ahmad khafis 
Published: July 2023

PROVIDING EDUCATION TO STUDENTS AT THE DARUL ILMI BATANG Islamic Boarding School THE IMPORTANCE OF SPORT WARMING FOR THE ELDERLY
One of the community service activities is socialization Providing Education on the Importance of Sport for the Elderly. We created this Sports Movement for the Elderly because we see that many elderly people are experiencing biological decline as visible symptoms of physical decline, one of which is cognitive decline. Cognitive function is related to physical activity that affects its structure and function, every physical movement that is carried out provides stimulation to the brain. Declining physical abilities have resulted in the elderly being a high-risk group in handling health problems. We also socialize this to children, even though they are not yet old, at least they understand and understand that later when they are elderly they still need to exercise. We socialize this activity smoothly and fully excitement.The socialization on Education on the Importance of Sport for Seniors was carried out on Saturday, December 17, 2022 at 13.00 WIB at Pondok Darul Ilmi Batang after rest activities. In the student team, which numbered 4 people, each of them had their respective assignments, including as presenters about the sequence of Warming up, Core Movement, and Cooling down and some as photo documentaries. , it turns out that many children ask about sports at an advanced age, here we can conclude that there is very good and conducive communication from the presenters and students which can be understood by students, although there are some students who still do not understand about participating in sports practices for the elderly

Keywords: Sport, Elderly
Pengembangan Masalah Matematika Berbobot (Rich Mathematical Task) untuk Meningkatkan Level Kemampuan Berpikir Siswa
Authors: Febrilia Baiq Rika Ayu , Juliangkary Eliska 
Published: July 2023

Kualitas pembelajaran matematika di kelas dipengaruhi oleh rancangan pembelajaran yang guru persiapkan jauh hari sebelum pembelajaran tersebut dilaksanakan, termasuk pula rancangan tugas atau permasalahan matematika. Suatu tugas atau permasalahan hendaknya mampu mendorong siswa dalam meningkatkan kemampuan berpikirnya. Salah satu tugas yang dapat mendorong siswa untuk berpikir tingkat tinggi adalah rich mathematical tasks. Pengembangan rich mathematical tasks sangat penting mengingat tugas ini mampu mendorong siswa untuk berpikir logis, kreatif, inovatif, komunikatif, dan evaluatif. Penelitian ini bertujuan untuk mengembangkan rancangan rich mathematical tasks untuk meningkatkan level kemampuan berpikir siswa. Metode yang digunakan adalah metode penelitian pengembangan (development research) yang terdiri dari tiga fase, yaitu fase studi preliminary, fase pengembangan, dan fase final. Akan tetapi, penelitian ini dilaporkan dalam dua fase pertama. Instrumen yang yang digunakan meliputi lembar validasi prototype dan lembar soal rich mathematical task. Hasil penelitian ini adalah dua permasalahan yang dikembangkan yang masing-masing terkonsentrasi pada materi Sistem Persamaan Linier Tiga Variabel (SPLTV) dan Perbandingan. Permasalahan ini kemudian divalidasi dan menghasilkan nilai keseluruhan 89.6% yang artinya permasalahan tersebut valid tanpa perlu direvisi. Uji coba dilaksanakan pada sekolah mitra dengan melibatkan 26 orang siswa pada kelas XI IPA 1. Hasil uji coba menunjukkan bahwa level kemampuan berpikir siswa masih berada pada level mengaplikasikan, meskipun terdapat beberapa siswa yang menunjukkan adanya level menganalisis.
TWO POINT FUZZY BOUNDARY VALUE PROBLEM WITH EXTENSION PRINCIPLE USING HEAVISIDE FUNCTION
Authors: CEYLAN Tahir 
Published: July 2023

In this paper we deal with the fuzzy eigenfunctions of the two point fuzzy
boundary value problem (FBVP) with fuzzy coefficient of the boundary
conditions. The fuzzy solution is obtained from the Zadeh's extension
principle using the Heaviside function. The eigenvalues and the fuzzy
eigenfunctions of the boundary value problem are found using the Wronskian
functions. We present an example in order to compare the proposed solution.
Substrate stiffness can affect the crosstalk between adipose derived mesenchymal stem cells and macrophages in bone tissue engineering
Authors: Liu Zeyang , Liu Jin , Li Jipeng , Li Yinwei , Sun Jing , Deng Yuan , Zhou Huifang 
Published: July 2023

Purpose: This study aimed to explore the effect of biomaterials with different stiffness on Adipose Derived Mesenchymal Stem Cells (ADSC)–macrophage crosstalk in bone tissue engineering and its role in bone repair.Methods: Biomaterials with Young’s modulus of 64 and 0.2 kPa were selected, and the crosstalk between ADSCs and macrophages was investigated by means of conditioned medium treatment and cell co-culture, respectively. Polymerase chain reaction (PCR) and flow cytometry were used to evaluate the polarization of macrophages. Alkaline phosphatase (ALP) and alizarin red staining (ARS) solutions were used to evaluate the osteogenic differentiation of ADSCs. Transwell assay was used to evaluate the chemotaxis of ADSCs and macrophages. Moreover, mass spectrometry proteomics was used to analyze the secreted protein profile of ADSCs of different substrates and macrophages in different polarization states.Results: On exploring the influence of biomaterials on macrophages from ADSCs on different substrates, we found that CD163 and CD206 expression levels in macrophages were significantly higher in the 64-kPa group than in the 0.2-kPa group in conditioned medium treatment and cell co-culture. Flow cytometry showed that more cells became CD163+ or CD206+ cells in the 64-kPa group under conditioned medium treatment or cell co-culture. The Transwell assay showed that more macrophages migrated to the lower chamber in the 64-kPa group. The proteomic analysis found that ADSCs in the 64-kPa group secreted more immunomodulatory proteins, such as LBP and RBP4, to improve the repair microenvironment. On exploring the influence of biomaterials on ADSCs from macrophages in different polarization states, we found that ALP and ARS levels in ADSCs were significantly higher in the M2 group than in the other three groups (NC, M0, and M1 groups) in both conditioned medium treatment and cell co-culture. The Transwell assay showed that more ADSCs migrated to the lower chamber in the M2 group. The proteomic analysis found that M2 macrophages secreted more extracellular remodeling proteins, such as LRP1, to promote bone repair.Conclusion: In bone tissue engineering, the stiffness of repair biomaterials can affect the crosstalk between ADSCs and macrophages, thereby regulating local repair immunity and affecting bone repair.
Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti-adipogenesis, and potential angiogenesis
Authors: Gong Weimin , Li Molin , Zhao Lizhou , Wang Pengtao , Wang Xiaofang , Wang Bo , Liu Xing , Tu Xiaolin 
Published: July 2023

The safe and effective use of Wnt signaling is a hot topic in developing osteogenic drugs. SB216763 (S33) is a widely used highly specific GSK3β inhibitor. Here, we show that S33 initiates canonical Wnt signaling by inhibiting GSK3β activity in the bone marrow stromal cell line ST2 and increases osteoblast marker alkaline phosphatase activity, osteoblast marker gene expression including Alpl, Col1α1, and Runx2, promoting osteogenic differentiation and mineralization of ST2 cells. In addition, S33 suppressed the expression of adipogenic transcription factors Pparg and Cebpa in ST2 cells to suppress adipogenesis. ICRT-14, a specific transcriptional inhibitor of Wnt signaling, reversed the effects of S33 on the differentiation of ST2 cells. S33 also increased the expression of osteoclast cytokines RANKL and Opg but decreased the RANKL/Opg ratio and had the potential to inhibit osteoclast differentiation. In addition, we printed the PSCI3D (polycaprolactone, S33, cell-integrated 3D) scaffolds using a newly established integrated 3D printing system for hard materials and cells. S33 sustained release in the hydrogel of the scaffold with 25.4% release on day 1% and 81.7% release over 7 days. Cells in the scaffolds had good cell viability. The ratio of live/dead cells remained above 94% for 7 days, while the cells in the scaffolds proliferated linearly, and the proliferative activity of the PSCI3D scaffold group increased 1.4-fold and 1.7-fold on days 4 and 7, respectively. Similarly, in PSCI3D scaffolds, osteogenic differentiation of st2 cells was increased. The alkaline phosphatase activity increased 1.4- and 4.0-fold on days 7 and 14, respectively, and mineralization increased 1.7-fold at 21 days. In addition, PSCI3D conditioned medium promoted migration and tubulogenesis of HUVECs, and S33 upregulated the expression of Vegfa, a key factor in angiogenesis. In conclusion, our study suggests that S33 functions in osteogenesis, anti-adipogenesis, and potential inhibition of osteoclast differentiation. And the sustained release of S33 in PSCI3D scaffolds creates a safe osteogenic niche, which promotes cell proliferation, osteogenesis, and angiogenesis and has application prospects.
Synthesis and antibacterial activities of Ag-TiO2/ZIF-8
Authors: Bao Siqi , Sun Shuanghui , Li Lin , Xu Lei 
Published: July 2023

In recent years, massive bacterial infections have led to human illness and death, reminding us of the urgent need to develop effective and long-lasting antimicrobial materials. In this paper, Ag-TiO2/ZIF-8 with good environmental friendliness and biological antibacterial activity was prepared by solvothermal method. The structure and morphology of the synthesized materials were characterized by XRD, FT-IR, SEM-EDS, TEM, XPS, and BET. To investigate the antibacterial activity of the synthesized samples, Escherichia coli and Bacillus subtilis were used as target bacteria for experimental studies of zone of inhibition, bacterial growth curves, minimum bactericidal concentration and antibacterial durability. The results demonstrated that 20 wt.%Ag-TiO2/ZIF-8 had the best bacteriostatic effect on E. coli and B. subtilis under dark and UV conditions compared to TiO2 and ZIF-8. Under the same conditions, the diameter of the inhibition circle of 20 wt% Ag-TiO2/ZIF-8 is 8.5–11.5 mm larger than that of its constituent material 4 wt% Ag-TiO2, with more obvious antibacterial effect and better antibacterial performance. It is also proposed that the excellent antibacterial activity of Ag-TiO2/ZIF-8 is due to the synergistic effect of Ag-TiO2 and ZIF-8 under UV light. In addition, the prepared material has good stability and durability with effective antimicrobial activity for more than 5 months.
Structure of gut microbiota and characteristics of fecal metabolites in patients with lung cancer
Authors: Lu Xingbing , Xiong Li , Zheng Xi , Yu Qiuju , Xiao Yuling , Xie Yi 
Published: July 2023

ObjectiveThe gut micro-biome plays a pivotal role in the progression of lung cancer. However, the specific mechanisms by which the intestinal microbiota and its metabolites are involved in the lung cancer process remain unclear.MethodStool samples from 52 patients with lung cancer and 29 healthy control individuals were collected and subjected to 16S rRNA gene amplification sequencing and non-targeted gas/liquid chromatography-mass spectrometry metabolomics analysis. Then microbiota, metabolites and potential signaling pathways that may play an important role in the disease were filtered.ResultsFirmicutes, Clostridia, Bacteroidacea, Bacteroides, and Lachnospira showed a greater abundance in healthy controls. In contrast, the Ruminococcus gnavus(R.gnavus) was significantly upregulated in lung cancer patients. In this respect, the micro-biome of the squamous cell carcinoma(SCC)group demonstrated a relatively higher abundance of Proteobacteria, Gammaproteobacteria, Bacteroides,and Enterobacteriaceae, as well as higher abundances of Fusicatenibacter and Roseburia in adenocarcinoma(ADC) group. Metabolomic analysis showed significant alterations in fecal metabolites including including quinic acid, 3-hydroxybenzoic acid,1-methylhydantoin,3,4-dihydroxydrocinnamic acid and 3,4-dihydroxybenzeneacetic acid were significantly altered in lung cancer patients. Additionally, the R.gnavus and Fusicatenibacter of lung cancer were associated with multiple metabolite levels.ConclusionOur study provides essential guidance for a fundamental systematic and multilevel assessment of the contribution of gut micro-biome and their metabolites in lung cancer,which has great potential for understanding the pathogenesis of lung cancer and for better early prevention and targeted interventions.
External validation of the REMEMBER score
Authors: Peivandi Armin Darius , Welp Henryk , Kintrup Sebastian , Wagner Nana Maria , Dell’Aquila Angelo Maria 
Published: July 2023

BackgroundThe use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) after coronary artery bypass grafting (CABG) is associated with high in-hospital mortality rates. The pRedicting mortality in patients undergoing venoarterial Extracorporeal MEMBrane oxygenation after coronary artEry bypass gRafting (REMEMBER) score has been created to predict in-hospital mortality in this subgroup of patients. The aim of this study is to externally validate the REMEMBER score.MethodsAll CABG patients who received VA-ECMO during or after the operation at our center between 01/2012 and 12/2021 were included in the analysis. Discrimination was assessed using concordance statistics, visualized by ROC curve analysis. Calibration-in-the-large and Calibration slope were tested separately.ResultsA total of 107 patients (male: n = 78, 72.9%) were included in this study. The in-hospital mortality rate in our cohort was 45.8% compared with 55% in the original study. The REMEMBER score median predicted mortality rate was 52% (76.9–36%). However, the REMEMBER score showed low discriminative ability [AUC: 0.623 (p = 0.0244; 95% CI = 0.524–0.715)] and inaccurate calibration (intercept = 0.25074; p = 0.0195; slope = 0.39504; p = 0.0303), indicating poor performance.ConclusionsThe REMEMBER score did not predict in-hospital mortality and was therefore not applicable in our cohort of patients. Additional external validation studies in a multicenter setting are therefore advisable.
Using machine learning to identify patient characteristics to predict mortality of in-patients with COVID-19 in South Florida
Authors: Datta Debarshi , George Dalmida Safiya , Martinez Laurie , Newman David , Hashemi Javad , Khoshgoftaar Taghi M. , Shorten Connor , Sareli Candice , Eckardt Paula 
Published: July 2023

IntroductionThe SARS-CoV-2 (COVID-19) pandemic has created substantial health and economic burdens in the US and worldwide. As new variants continuously emerge, predicting critical clinical events in the context of relevant individual risks is a promising option for reducing the overall burden of COVID-19. This study aims to train an AI-driven decision support system that helps build a model to understand the most important features that predict the “mortality” of patients hospitalized with COVID-19.MethodsWe conducted a retrospective analysis of “5,371” patients hospitalized for COVID-19-related symptoms from the South Florida Memorial Health Care System between March 14th, 2020, and January 16th, 2021. A data set comprising patients’ sociodemographic characteristics, pre-existing health information, and medication was analyzed. We trained Random Forest classifier to predict “mortality” for patients hospitalized with COVID-19.ResultsBased on the interpretability of the model, age emerged as the primary predictor of “mortality”, followed by diarrhea, diabetes, hypertension, BMI, early stages of kidney disease, smoking status, sex, pneumonia, and race in descending order of importance. Notably, individuals aged over 65 years (referred to as “older adults”), males, Whites, Hispanics, and current smokers were identified as being at higher risk of death. Additionally, BMI, specifically in the overweight and obese categories, significantly predicted “mortality”. These findings indicated that the model effectively learned from various categories, such as patients' sociodemographic characteristics, pre-hospital comorbidities, and medications, with a predominant focus on characterizing pre-hospital comorbidities. Consequently, the model demonstrated the ability to predict “mortality” with transparency and reliability.ConclusionAI can potentially provide healthcare workers with the ability to stratify patients and streamline optimal care solutions when time is of the essence and resources are limited. This work sets the platform for future work that forecasts patient responses to treatments at various levels of disease severity and assesses health disparities and patient conditions that promote improved health care in a broader context. This study contributed to one of the first predictive analyses applying AI/ML techniques to COVID-19 data using a vast sample from South Florida.
The dynamic expression of SOX17 in germ cells from human female foetus and adult ovaries after specification
Authors: Luo Ying-Yi , Jie Hui-Ying , Huang Ke-Jun , Cai Bing , Zhou Xiu , Liang Ming-Yi , Zhou Can-Quan , Mai Qing-Yun 
Published: July 2023

BackgroundSOX17 has been identified as a critical factor in specification of human primordial germ cells, but whether SOX17 regulates development of germ cells after sex differentiation is poorly understood. MethodsWe collected specimens of gonadal ridge from an embryo (n=1), and ovaries of foetuses (n=23) and adults (n=3). Germ cells were labelled with SOX17, VASA (classic germ cells marker), phosphohistone H3 (PHH3, mitosis marker) and synaptonemal complex protein 3 (SCP3, meiosis marker). ResultsSOX17 was detected in both cytoplasm and nucleus of oogonia and oocytes of primordial and primary follicles from 15 to 28 gestational weeks (GW). However, it was exclusively expressed in cytoplasm of oogonia at 7 GW, and in nucleus of oocytes in secondary follicles. Co-expression rates of SOX17 in VASA+ germ cells ranged from 81.29% to 97.81% in foetuses. Co-staining rates of SOX17 and PHH3 or SCP3 were 0%-34% and 0%-57%, respectively. Interestingly, we distinguished a subpopulation of SOX17+VASA- germ cells in fetal ovaries. These cells clustered in the cortex and could be co-stained with the mitosis marker PHH3 but not the meiosis marker SCP3.ConclusionsThe dynamic expression of SOX17 was detected in human female germ cells. We discovered a population of SOX17+ VASA- germ cells clustering at the cortex of ovaries. We could not find a relationship between mitosis or meiosis and SOX17 or VASA staining in germ cells. Our findings provide insight into the potential role of SOX17 involving germ cells maturation after specification, although the mechanism is unclear and needs further investigation.