bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Subjective Functional Outcomes of Prostate Cancer: Prostatectomy vs Radiation
Authors: Gaura Kellie , Beatty Bryce , Ohlde Natalie , Spaan Johannie M. , Guenther Elisabeth 
Published: January 2023

Background Long-term subjective outcomes of prostate cancer are relatively unknown. The Oregon Urology Institute (OUI) has been collecting subjective functional outcome data to help determine the long-term subjective outcomes of prostatectomy vs radiation therapy. Methods Patients treated at OUI completed interval post-treatment questionnaires that assessed: urinary, bowel, sexual, and hormonal function, and overall treatment satisfaction. Two cohorts were established: prostatectomy vs radiation. Results from each cohort were compared and analyzed with a linear mixed effect model. Results Our longitudinal dataset includes a prostatectomy cohort of 410 patients and radiation therapy cohort of 416 patients surveyed at the 3-month interval, but the number of patients decreased after each time interval (ie 3, 6, 9, and 12 months and then annually for up till 14 years post-treatment). Urinary and sexual functional scores decreased by 4% and 8% after radiation, whereas prostatectomy had a 5% and 13% increase over time post-treatment, respectively. Over time, patients treated with prostatectomy were found to be more satisfied with the outcome of their treatment than patients receiving radiation therapy. Conclusion Prostatectomy and radiation therapy had impacts on quality of life measurements that emphasize the importance of making the best-informed decision in each unique situation.
Mock-up experimental study on the performance of a combined cooling-domestic hot water-ground source heat pump system
Authors: Zhang Xinwen , Rhee Kyu-Nam , Jung Gun-Joo 
Published: January 2023

A ground source heat pump (GSHP) delivers heat from a condenser to the ground when it operates with cooling mode. However, the ground temperature increases when the GSHP system operates for a long time. The increased ground temperature can deteriorate the GSHP’s coefficient of performance (COP). To maintain the balance between the ground temperature and COP, the condensation heat from the cooling GSHP can be used for other heating systems before it is transferred to the ground. This study proposes a combined GSHP system connecting a three RT cooling GSHP with a 1.5 RT domestic hot water (DHW) heat pump, and the performance of the system was evaluated through mock-up experiments. In the combined GSHP system, the condensation heat of the cooling system was used as the heat source of the DHW system. Therefore, the ground temperature could be reduced, and the performances of both the GSHP cooler and DHW heater pump could be enhanced. Mock-up experiments for performance evaluation were conducted with cooling-only, DHW-only, and cooling-DHW operational modes. The results showed that cooling-DHW operation slowed down the change in heat source temperature. In comparison with those of the cooling-only and DWH-only heat pumps, the COPs of the cooling heat pump and DHW heat pump of the combined system were increased by 12.93% and 15.47%, respectively. Moreover, the total COP of the cooling-DHW combined GSHP system increased by 4.4% and 29.55% in comparison with those of the cooling-only GSHP and DHW-only GSHP systems, respectively. Practical application A combined GSHP system was proposed by connecting a GSHP for space cooling with a heat pump for DHW to mitigate the ground temperature changes due to the long-term operation of the GSHP system. The combined system reuses the condensation heat generated by the cooling heat pump as the heat source of the DHW heat pump for ensuring the system performance and building energy saving. Therefore, this system is suitable for buildings with large energy use and heavy hot water demand, especially in summer, such as hospital and hotel buildings.
Coparenting relationship quality and breastfeeding duration for dual earner new parents
Authors: Yan Jia (Julia) , Berrigan Miranda N. , Wang Jingyi , Kamp Dush Claire M. , Schoppe-Sullivan Sarah J 
Published: January 2023

We tested the prospective associations between coparenting relationship quality and breastfeeding duration among 164 dual-earner, cisgender, heterosexual couples identifying as mothers and fathers at the transition to parenthood. We hypothesized that mothers who perceived higher quality (more supportive and less undermining) coparenting relationships would breastfeed for a longer duration. At 3 months after childbirth, mothers reported their perceptions of coparenting relationship quality using the Coparenting Relationship Scale. Mothers reported their breastfeeding behaviors at four time points—when their infant was 3, 6, 9 months and 12–36 months old. Survival analysis revealed that higher quality coparenting relationships were associated with longer breastfeeding duration. This association was only observed among families of girls. This study highlights the interactive role of coparenting relationship quality and infant sex as proximal contexts that may shape breastfeeding practices.
Association Between Patient Race and Ethnicity and Outcomes With COVID-19: A Retrospective Analysis From a Large Mid-Atlantic Health System
Authors: Rao Anirudh , Alnababteh Muhtadi H. , Avila-Quintero Victor J. , Flores Jose M. , Laing Nina E. , Boyd David A. , Yu Jennifer , Ahmed Naheed , Groninger Hunter , Zaaqoq Akram M. 
Published: January 2023

Background Members of racial and ethnic minority groups have been disproportionately impacted by coronavirus-2019 (COVID-19). The objective of the study is to describe associations between race and ethnicity on clinical outcomes such as need for mechanical ventilation and mortality. Methods Retrospective cohort study of patients with severe COVID-19 infection admitted within a large, not-for-profit healthcare system in the mid-Atlantic region between March and July, 2020. Patient demographic data and clinical outcomes were abstracted from the electronic health record. Logistic regressions were performed to estimate associations between race and ethnicity and the clinical outcomes. Results The study population (N  =  2931) was stratified into 1 of 3 subgroups: non-Hispanic White (n  =  466), non-Hispanic Black (n  =  1611), and Hispanic (n  =  654). The average age of White, Black, and Hispanic patients was 69  ±  17.06, 64  ±  15.9, and 50  ±  15.53 years old, respectively ( P < .001). Compared to White patients, Black and Hispanic patients were at increased odds of needing mechanical ventilation due to COVID-19 pneumonia (odds ratio [OR] Black  =  1.35, 95% confidence interval [CI]  =  1.04 to 1.75, P < .05; OR Hispanic  =  1.43, 95% CI  =  1.06 to 1.93, P < .05). When compared to White patients, Hispanic patients were at decreased odds of death (OR  =  0.45, 95% CI  =  0.32 to 0.63, P < .001). However, when adjusting for age, there were no statistically significant differences in the odds of death between these groups (adjusted OR [aOR] Black  =  1.05, 95% CI  =  0.80 to 1.38, P  =  .71; aOR Hispanic  =  1.10, 95% CI  =  0.76 to 1.60, P  =  .62). Conclusion Our analysis demonstrated that Hispanic patients were more likely require mechanical ventilation but had lower mortality when compared to White patients, with lower average age likely mediating this association. These findings emphasize the importance of outreach efforts to communities of color to increase prevention measures and vaccination uptake to reduce infection with COVID-19.
Transjugular Intrahepatic Portosystemic Shunt in Liver Transplant Recipients: Outcomes in Six Adult Patients
Authors: Masek Jan , Fejfar Tomas , Frankova Sona , Husova Libuse , Krajina Antonin , Renc Ondrej , Chovanec Vendelin , Raupach Jan 
Published: January 2023

Objectives Transjugular intrahepatic portosystemic shunt (TIPS) is regularly used in treatment of clinically significant portal hypertension. Liver transplant recipients are, however, rarely indicated for the procedure. The study retrospectively examines the results of TIPS placement in 6 patients after OLT. Methods 4 males and 2 females (aged 36 to 62 years), treated with TIPS between 2007 a 2018, were included in the study. 5 patients had previously undergone liver transplantation for liver graft cirrhosis, 1 patient for Budd-Chiari syndrome. The piggyback caval reconstruction technique was selected in 4/6 cases. PH developed after OLT due to the recurrence of underlying liver condition and sinusoidal obstruction syndrome in half of the cases, respectively. Indications for TIPS were refractory ascites in 4 cases and variceal bleeding in 2 cases. Results Standard TIPS technique was used and technical success was achieved in all cases with a procedure-related complication in 1 patient. One patient died shortly after TIPS placement. The remaining patients all reported regression of clinically significant PH. Late complications appeared in 2 patients. Liver retransplantation after TIPS creation was performed in 1 case. Median TIPS patency was 55 months. 2/6 patient continue to thrive with a patent shunt. Conclusions Transjugular intrahepatic portosystemic shunt in OLT recipients is technically feasible. Favorable clinical outcomes were reported particularly in patients treated for sinusoidal obstruction syndrome who were indicated to TIPS for refractory ascites.
Fast treatment of anterior shoulder dislocations with two sedation-free methods: The Davos self-reduction method and Arlt method
Authors: Widmer Lukas Werner , Lerch Till Dominic , Genthner Anna , Pozzi Lara , Geiger James , Frei Hans-Curd 
Published: January 2023

Background Various reduction techniques exist to treat traumatic shoulder dislocation, but best management remains unclear. Aims To investigate the reduction rate of traumatic anteroinferior shoulder dislocations using two sedation-free techniques and success rates of subgroups. Methods A single-center study was performed analysing shoulder dislocations in a two-year period. Adult patients with anteroinferior shoulder dislocation were included. Two sedation-free reduction techniques were used: the Davos self-reduction technique and the Arlt-chair technique. Two attempts were performed before sedation. All patients gave informed consent to study participation. Results The investigated 106 patients (106 shoulder dislocations) had a mean age of 48 ± 18 years (74% male patients). The majority occurred during winter sports (76%). The overall success rate for both sedation-free reduction techniques was 82% (87 reduced shoulders, two attempts). A significantly increased success rate was found in patients without greater tuberosity fracture (86% without vs. 68% with fracture, p = 0.002) and for patients with repeated dislocation (93% vs. 80% for primary dislocation, p = 0.004). Time for reduction was 5 minutes (Davos technique) and 1 minute (Arlt-chair-technique). Associated injuries were mostly Hill Sachs lesions (78%). There was no major complication and no new-onset sensory deficit. Conclusion Davos and Arlt reduction techniques allowed sedation-free and fast treatment for anteroinferior shoulder dislocation during winter sports.
Telemedicine as bridge to the offline world for person affected with problematic internet use or internet use disorder and concerned significant others
Authors: Bottel Laura , te Wildt Bert Theodor , Brand Matthias , Pape Magdalena , Herpertz Stephan , Dieris-Hirche Jan 
Published: January 2023

Introduction Internet use disorder is a disorder of the digital age and presents a growing problem worldwide . It appears that due to structural and personal barriers, many persons affected (PA) and Concerned Significant Others (CSO) do not reach the health care system so far and thus a chronification of the pathology can proceed. Methods A telemedicine counseling service for PA and CSO of PA unwilling to enter treatment with two webcam-based sessions of 60 minutes for each group was created with the aim of reaching out to PA and CSO to provide a low-threshold support and refer the participants to the local health care system. Motivational interviewing for PA and CRAFT (Community Reinforcement and Family Training) for CSO were used as methods. Participants answered questions about their Internet use and sociodemographic data and six months after participation, participants were asked via email if they entered the local health care system. CSO answered the questions for themselves and in a third-party rating for PA unwilling to enter treatment. Results 107 PA (34 years ( SD = 13.64), 86% male) and 38 CSO (53 years ( SD = 6.11), 28.9% male) participated in the two telemedicine sessions. After participation, 43.9% of the PA and 42.1% of the CSO reached the health care system. When there was consistency between the location of telemedicine consultation and treatment locally, over 90% of participants arrived (PA: 92.3%, CSO: 100%). Conclusion The results from this study reveal that telemedicine services could be a promising approach to address PA and CSO and build a bridge to the local health care system. Future studies should verify if these results can be replicated in randomized controlled trials.
Impact of a digital health literacy intervention and risk predictors for multimorbidity among poor women of reproductive years: Results of a randomized-controlled trial
Authors: Jafree Sara Rizvi , Muzammil Anam , Burhan Syeda Khadija , Bukhari Nadia , Fischer Florian 
Published: January 2023

Objective The objective of this study was to deliver an intervention to improve health awareness for infection prevention, hygiene, and sanitation to assess its impact. Furthermore, it aimed to identify the risk of multimorbidity in women of reproductive years from low socio-economic background. Methods A randomized control trial was conducted in Pakistan among women aged 15–45 years. Overall, 820 women participated in the baseline survey; 388 women were part of the control group and 360 of the intervention group. A digital health literacy intervention was delivered by 91 trained community health workers. Data were analyzed using descriptive statistics and multivariate logistic regression. Results About 35.9% of women suffered from multimorbidity. The intervention group showed higher odds of confidence in managing health with respect to skill and technique acquisition (AOR = 2.21; 95% CI 1.01–4.84), self-monitoring and insight (AOR = 2.97; 95% CI 1.29–6.80) as well as sanitation and hygiene (AOR = 1.42; 95% CI 1.07–1.93). Two primary outcomes related to hand hygiene and protective behavior against infection did not show any significant improvement. The secondary outcomes of the study related to impact on overall health-related quality of life, social integration and support, and emotional well-being also did not show any significant improvement. Conclusions Digital health literacy interventions and multimorbidity management for women of reproductive years at the primary level are a way forward to alleviate communicable and non-communicable disease burden in developing countries like Pakistan. These efforts are also critical to improve maternal and child health in developing regions.
Midterm Clinical and Radiographic Outcomes of the Calcaneal Z-Osteotomy for the Correction of Cavovarus Foot
Authors: Chen Jie , Ramanathan Deepak , Sharma Akhil , Adams Samuel B. , DeOrio James K. 
Published: January 2023

Background: The Malerba calcaneal Z-osteotomy is an operative procedure to treat the hindfoot varus component of adult cavovarus deformity. Basic science studies support the corrective ability of this osteotomy. However, there have been no published midterm clinical and radiographic results. The purpose of this article is to describe the radiographic and clinical improvement in a series of patients treated with this osteotomy. Methods: A retrospective chart review identified 14 feet in 12 patients from January 2013 to August 2018 who met minimal follow-up criteria. Preoperative visual analog scale (VAS) scores, Foot Function Index (FFI) scores, and American Orthopaedic Foot & Ankle Society (AOFAS) scores were compared with postoperative scores. Preoperative Meary angle, calcaneal pitch, and hindfoot alignment were also compared with postoperative measurements. Complications and radiographic union were recorded. Results: At a mean of 80 months, VAS, FFI, and AOFAS scores improved from 7.86 to 1.64, 57.78% to 18.11%, and 39.57 to 80.71, respectively (all P < .001). At a mean of 15 months, Meary angle, calcaneal pitch, and hindfoot alignment improved from 11.14 to 6.64 degrees ( P < .001), 30.93 to 27.43 degrees ( P = .005), and 19.83 degrees varus to 8.50 degrees varus ( P < .001). There was 1 nonunion and 1 postoperative sural nerve neuralgia, but both patients ultimately did well clinically. There were no instances of postoperative tarsal tunnel syndrome. All patients stated that they would have the procedure done again. Conclusion: The calcaneal Z-osteotomy is an effective method to treat adult hindfoot cavovarus deformity. All patients had good clinical outcomes with minimal complications. Level of Evidence: Level IV, case series.
“We Operate as an Organ”: Parent Experiences of Having a Child With Type 1 Diabetes in a Rural Area
Authors: Lewis Laura Foran , Brower Paige MacDonald , Narkewicz Sarah 
Published: January 2023

Purpose: The purpose of this study is to explore the experiences of parents of children with type 1 diabetes mellitus (T1DM) who are living in rural areas. Individuals living in rural areas face barriers to accessing health care that lead to significant health disparities with increased morbidity and mortality. There is a need to understand the unique experiences of those living in rural communities to support their health needs. Methods: In this qualitative study, a convenience sample of 11 parents of children who were diagnosed with T1DM in the last 10 years living in Vermont were recruited through connections with local health professionals and family support networks and interviewed about their experiences. Interviews were transcribed verbatim and analyzed using Braun and Clarke’s 6-step approach to reflexive thematic analysis. Results: Five themes were identified to capture the experience of parenting a child with T1DM in a rural community, including enduring emotional traumas, living life on call, adapting to everyday challenges, lacking a safety net for support, and finding a rhythm. Conclusions: Although findings echo many themes found in previous studies on experiences of parents of children with T1DM, participants also identified unique barriers such as physical distance from formal and informal support systems, unreliable and/or insufficient technological resources, and lack of understanding of T1DM by their communities, including among child care and schools. Diabetes care and education specialists working with families living in rural areas must explore ways to educate key supports to these families to minimize isolation, stigma, and burnout among parents.
Proteome alterations in erythrocytes with PIEZO1 gain-of-function mutations
Authors: Andolfo Immacolata , Monaco Vittoria , Cozzolino Flora , Rosato Barbara Eleni , Marra Roberta , Cerbone Vincenza , Pinto Valeria Maria , Forni Gian Luca , Unal Sule , Iolascon Achille , Monti Maria , Russo Roberta 
Published: January 2023

Abstract
Gain-of-function mutations in PIEZO1 cause dehydrated hereditary stomatocytosis (DHS) or hereditary xerocytosis, an autosomal dominant hemolytic anemia characterized by high reticulocyte count, a tendency to macrocytosis, and mild jaundice, as well as by other variably penetrant clinical features, such as perinatal edema, severe thromboembolic complications after splenectomy, and hepatic iron overload. PIEZO1 mutations in DHS lead to slowed inactivation kinetics of the ion channel and/or facilitation of channel opening in response to physiological stimuli.
To characterize the alterations of red blood cell proteome in patients with mutated PIEZO1, we used a differential approach to compare the proteome of patients with DHS (16 patients from 13 unrelated ancestries) vs healthy individuals. We identified new components in the regulation of the complex landscape of erythrocytes ion and volume balance mediated by PIEZO1. Specifically, the main impaired processes in patients with DHS were ion homeostasis, transmembrane transport, regulation of vesicle-mediated transport, and the proteasomal catabolic process. Functional assays demonstrated coexpression of PIEZO1 and band 3 when PIEZO1 was activated. Moreover, the alteration of the vesicle-mediated transport was functionally demonstrated by an increased vesiculation rate in patients with DHS compared with healthy controls. This finding also provides an explanation of the pathogenetic mechanism underlying the increased thrombotic rate observed in these patients.
Finally, the newly identified proteins, involved in the intracellular signaling pathways altered by PIEZO1 mutations, could be used in the future as potential druggable targets in DHS.
Sphenopalatine ganglion volumetry in episodic cluster headache: from symptom laterality to cranial autonomic symptoms
Authors: Wu Jr-Wei , Chen Shu-Ting , Wang Yen-Feng , Lai Kuan-Lin , Chen Ting-Yi , Chen Shih-Pin , Chen Wei-Ta , Wang Shuu-Jiun 
Published: January 2023

Abstract
Background
Sphenopalatine ganglion (SPG) is a peripheral structure that plays an important role in cluster headache (CH). Hence, a reliable method to measure the volume of SPG is crucial for studying the peripheral mechanism of CH. Additionally, the association between the clinical profiles and the morphology of the SPG in CH remains undetermined. This study aims to use the manual measurement of SPG volume to investigate its associations with CH, including headache laterality, cranial autonomic symptoms (CASs), presence of restlessness or agitation, and other clinical profiles.

Methods
We prospectively recruited consecutive CH patients at a tertiary medical center between April 2020 and April 2022. A total of eighty side-locked, in-bout, episodic CH patients and 40 non-headache healthy controls received 1.5 T brain MRI focusing on structural neuroimaging of the SPG. The manual measurement process for SPG was under axial and sagittal FIESTA imaging, with reference T2 weight images (sagittal and axial) for localization. The inter-observer agreement of the SPG volume (both sides of the SPG from CH patients and controls) between the two observers was calculated. In CH patients, clinical profiles and the number of CASs (range 0–5) were recorded to analyze their association with SPG volume.

Results
The inter-observer agreement between the two raters was excellent for the new SPG volumetry method at 0.88 (95% CI: 0.84–0.90, p < 0.001). The mean [SD] SPG volume was larger in CH patients than in non-headache controls (35.89 [12.94] vs. 26.13 [8.62] μL, p < 0.001). In CH patients, the SPG volume was larger on the pain side than on the non-pain side (38.87 [14.71] vs. 32.91 [12.70] μL, p < 0.001). The number of CASs was positively moderately correlated with the pain-side SPG volume (Pearson r = 0.320, p = 0.004) but not the non-pain side SPG volume (Pearson r = 0.207, p = 0.066).

Conclusions
This proof-of-concept study successfully measured the SPG volume and demonstrated its associations with symptomatology in patients with episodic CH. The direct measurement of SPG provide insights into studies on peripheral mechanism of CH.