bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraperitoneal Chemotherapy without Bevacizumab versus Intravenous Chemotherapy plus Bevacizumab as Frontline Therapy in Advanced Ovarian Cancer
Authors: Ting Wan-Hua , Wang Hsiao-Feng , Chen Hui-Hua , Sun Hsu-Dong , Wei Ming-Chow , Lin Ho-Hsiung , Hsiao Sheng-Mou 
Published: March 2023

Abstract
Objectives
To compare the clinical outcomes between intravenous carboplatin/paclitaxel chemotherapy plus bevacizumab versus intraperitoneal cisplatin/paclitaxel chemotherapy without bevacizumab as the frontline treatment in women with advanced ovarian, fallopian tube and primary peritoneal cancer.
Methods
All consecutive women with stage II~IV cancer treated with either frontline intraperitoneal cisplatin/paclitaxel without bevacizumab (IP group) or intravenous carboplatin/paclitaxel with bevacizumab (IVB group) at a tertiary referral center were reviewed.
Results
A total of 59 women (IP group, n=44; IVB group, n=15) were reviewed. There was no significant difference in the progression-free survival (median: 33.6 versus 14.8 months, p=0.13). However, overall survival (OS) was significantly higher in the IP group, compared with the IVB group (median: not reached versus 31.7 months, p=0.02; adjusted hazard ratio (HR)=0.35, 95% confidence interval (CI)=0.10 to 1.07, p=0.065). Additional predictors for OS include cancer stage and the number of chemotherapy cycles. Besides, the standard dose of 100 mg/m2 cisplatin was a predictor for OS, compared with other intraperitoneal regimens (adjusted HR=0.14, 95% CI=0.02 to 0.87, p=0.03).
Conclusions
Intraperitoneal cisplatin/paclitaxel chemotherapy without bevacizumab seems to be better in OS, compared to intravenous carboplatin/paclitaxel chemotherapy with bevacizumab in the frontline treatment of women with advanced ovarian cancer.
A CNN model for predicting soil properties using VIS-NIR spectral data
Authors: Hosseinpour-Zarnaq Mohammad , Omid Mahmoud , Sarmadian Fereydoon , Ghasemi-Mobtaker Hassan 
Published: March 2023

Abstract
This research aims to develop a novel deep learning-based model for predicting soil properties based on visible and near-infrared (VIS-NIR) spectroscopy data. Soil samples were collected from the European topsoil dataset provided by the LUCAS project provides various soil physicochemical properties analyzed within 28 EU countries (including sand, silt, clay, pH, organic carbon, calcium carbonates (CaCO3), and N). In this study, one-dimensional (1D) convolutional neural network (CNN) models were developed using absorbance spectral data. The performance of feature learning from discrete wavelet transform as a powerful preprocessing method was tested. Moreover, the results of the proposed CNN model were compared with partial least squares regression (PLSR) with raw absorbance and optimum classical preprocessing (Savitzky-Golay smoothing with first-order derivative). The ratio of percent deviation (RPD) of CNN with absorbance data for prediction of OC, CaCO3, pH, N, sand, silt, and clay content were 4.02, 3.89, 2.82, 3.02, 1.63, 1.43, and 2.16, respectively. While the RPD of PLSR with optimal preprocessing of absorbance data for predicting the mentioned parameters were 2.89, 3.00, 2.79, 2.50, 1.37, 1.27, and 1.84, respectively. The study demonstrated the feasibility of using deep learning-based models and VIS-NIR spectral data as a rapid nondestructive tool for the assessment of important soil properties.
Responses of Trifolium repens L. root structure and function to shading and phosphorus shortage: limits to adaptative plasticity during establishment?
Authors: Gatti Maria Laura , Cornaglia Patricia Susana , Re Paula 
Published: March 2023

Abstract

Shading and low soil phosphorus availability may limit root growth of forage species in humid-temperate silvopastoral systems. However, plants are able to cope with such constraints by modifying root structure to improve the establishment and survival. The aim of this work was to evaluate the plasticity of different types of roots of Trifolium repens L. and its functional impact in the first two years of the species. A pot trial designed in 3 randomized complete block was carried out in sub-subdivided plots: main plot was the shading treatment (4 levels: full sun = 0% and 30%, 60% and 90% of photosynthetically active radiation (PAR) reduction), sub-plots were 2 cultivars of large-leafed (cv. Junín and cv. El Lucero) and sub-sub-plots were 2 phosphorous conditions (without P- and with added P+). Whole plants were harvested and the root system was divided into seminal taproot and fibrous roots: coarse roots (1 to ≤ 2 mm of diameter) and fine roots (≤ 1 mm of diameter). Even under 60% of shading, both cultivars were able to maintain root soil penetration and water and nutrients acquisition, regardless of the level of P. These functions were associated with the length and taproot diameter, specific taproot length and fine root biomass during establishment. Instead 90% of shading was a clear limit to plasticity and survival of the plants during the second year. Under mean PAR radiation > 212 µmol m− 2.s− 1 and P shortage, it is expected that the enrichment with large-leafed cultivars could be successful in these systems.
A novel subclonal rearrangement of the STRN3::PDGFRB genes in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects
Authors: Mi Yingchang , Wang Zhe , Liu Ting , Liu Wenbing , Gao Xin , Wan Li , Qiu Shaowei , Song Yang , Gu Runxia , Tian Zheng , Wang Min , Wang Jianxiang , Wei Shuning 
Published: March 2023

Abstract
Chromosome translocations in the 5q31-33 region are associated with a range of hematologic malignancies, some of which involve the platelet derived growth factor receptor beta (PDGFRB) gene. We report a case of acute myeloid leukemia (AML) with a mutation in the NPM1 gene (NPM1-mut AML) and a subclonal gene rearrangement involving the PDGFRB gene. We identified a novel fusion gene, STRN3::PDGFRB, resulting from t(5;14) (q32;q12) chromosomal rearrangement. Sequential FISH confirmed that approximately 15% of leukemic cells carried the PDGFRB gene rearrangement, which suggests that STRN3::PDGFRB is a previously unreported fusion gene in a subclone. Reverse transcription PCR (RT-PCR) and Sanger sequencing confirmed that the fusion gene consisted of STRN3 exon 7 fused to PDGFRB exon 11, resulting in a chimeric protein containing the coiled-coil domain of striatin-3 and the transmembrane and intracellular tyrosine kinase domains of the PDGFRB. The new protein exhibited distinct cytoplasmic localization and had leukemogenic effects, as demonstrated by its ability to transform Ba/F3 cells to growth factor independence and cause a fatal myelodysplastic/myeloproliferative neoplasms (MDS/MPN)-like disease in mice, which then transformant to T-cell lymphoblastic lymphoma in secondary recipients. Ba/F3 cells expressing STRN3::PDGFRB or ETV6::PDGFRB were sensitive to tyrosine kinase inhibitors (TKIs) and selinexor, but in virto experiments showed that the combination of imatinib and selinexor had a marked synergistic effect, although only the imatinib alone group could prolong the survival of T-cell blast transformation recipient mice. Our findings demonstrate the leukemogenic effects of the novel fusion gene and provide insights into the clone evolution of AML, which can be influenced by therapy selection. Furthermore, our results provide insight into the potential therapeutic options for patients with this type of mutation, as well as the need for careful consideration of treatment selection to prevent undesirable side effects.
The association between environmental cadmium exposure and parathyroid hormone levels
Authors: Tang Hongye , Wang Jiangchuan , Wang Rongzhou , Hu Nandong , Wei Zicheng , Zhu Guoying , Jin Taiyi , Chen Xiao 
Published: March 2023

Abstract
Cadmium exposure is associated with renal dysfunction and bone damage. Chronic kidney disease and bone loss are also related to parathyroid hormone (PTH). However, whether cadmium exposure affect PTH level is not completely understood. In this study, we observed the association between environmental cadmium exposure and parathyroid hormone levels in a Chinese population. A ChinaCd study was performed in China in 1990s which included 790 subjects living in heavily, moderately and low cadmium polluted area. 354 of them (121men and 233 women) also had the data of serum PTH. The cadmium levels in blood (BCd) and urine (UCd) were determined by flame atomic absorption spectrometry. Serum PTH was detected by immunoradiometric assay. Renal function was assessed based on urinary N-acetyl-βd-glucosaminidase (UNAG) and urinary albumin (UALB). The median BCd and UCd levels were 4.69 µg/L and 5.50 µg/g creatinine. The BCd, UCd, UNAG and UALB levels in subjects with low PTH (< 5.0 ng/L) were significantly higher than those with PTH ≥ 5.0 ng/L (p < 0.05 or p < 0.01). Spearman correlation analysis also showed that UCd level was negatively correlated to PTH levels (r = -0.17, p = 0.008). A weak correlation was also observed between BCd and PTH level (r = -0.11, p = 0.09). Univariable and mutivariable logistic regression analysis demonstrated that high BCd (> 10 µg/L) (odds ratio (OR) = 2.26, 95% confidence interval (CI):1.10–4.63; OR = 2.36, 95%CI: 1.11–5.05) and UCd level (> 20 µg/g cr) (OR = 2.84, 95%CI:1.32–6.10; OR = 2.97, 95%CI: 1.25–7.05) were associated with high risk of low PTH. Our data showed that environmental cadmium exposure was associated with low PTH level.
Putting conservation gardening into practice
Authors: Munschek Marius , Witt Reinhard , Kaltofen Katrin , Segar Josiane , Wirth Christian , Weigelt Alexandra , Engelmann Rolf A. , Staude Ingmar R. 
Published: March 2023

Abstract
Conservation gardening (CG) is the widespread planting of urban green spaces with declining native plant species and the transformation of the gardening industry into a socio-ecological conservation tool. However, information on which plants are amenable, what conditions they require, and where they can be purchased remains scarce and not readily available. Using Germany as an example, we demonstrate a workflow that synthesizes such data. We synthesized the Red Lists of all 16 federal states in Germany, and text-mined a comprehensive platform for garden plants, as well as multiple German producers of native plants. We summarize all available data via a user-friendly app (https://conservation-gardening.shinyapps.io/app-en/), allowing gardeners to retrieve region-specific lists of CG plants, as well as corresponding planting and purchasing advice. We found that a median of 845 plant species are red-listed across federal states (ranging from 515 to 1,123), with a median of 41% of species amenable to CG (ranging from 29–53%), totalling in 988 CG species. 650 (66%) of these are already available for purchase. We found that many CG plants are drought-tolerant and require less fertilizer on average, with implications for long-term urban planning and climate adaptation. Together with gardening experts, we present purchasable CG balcony plants for each federal state, highlighting that CG can happen now and also for people without gardens. Our analysis suggests plant extinction risk could potentially be reduced by a median of 29% across Germany if CG were widely implemented. Our study highlights a considerable potential for CG to initiate transformative change to help bend the curve of biodiversity loss.
The Impact of Exports and FDI on Economic Growth : Evidence from Nine European Union Member States
Authors: Yeboah Evans , Baffour Alexander Amo 
Published: March 2023

Abstract

Exports and FDI are part of the macroeconomic variables which some researchers have studied through a cross-country approach to assessing the dynamic in economic growth. This study investigates the significance of exports and FDI in some selected European Union member states including Bulgaria, Czech Republic, Estonia, Hungary, Lithuania, Latvia, Poland, Romania, and Slovakia. The study used data from the World Bank from 1995 to 2021 and analyzed it through a panel model estimation. The econometrics test employed includes the pooled model, stationarity test, panel specification, and Fixed effect model. The stationarity test indicated that the variables(exports, GDP, and FDI) were non-stationarity at a level and integrated with the first-order difference. The panel specification test showed that the fixed effect model was the most adequate over the pooled and random effect models. The results from the fixed effect model indicated that exports and FDI positively stimulate economic growth in these selected countries. The results further show that Poland’s economy enjoyed more impacts from exports and FDI, followed by Romania, whereas Estonia’s economy witnessed the lowest impact. The findings revealed that exports support economic development in these EU countries more than FDI. The study recommends that policymakers implement sound investment policies to attract more FDI inflows.
Development of fishing boat collision models in extreme weather using computer simulation
Authors: Sunardi  , Choiron Moch. Agus , Sugiarto  , Setyarini Putu Hadi 
Published: March 2023

The incidence of fishing boat accidents in Indonesia is very worrying, with 342 people dying during 2018–2020. Based on this, it is crucial to investigate the construction strength of fishing vessels against the possibility of a collision. In this study, the fishing boat due to the impact load was investigated in extreme weather conditions using Finite Element Method (FEM) analysis. Traditional fishing boat was constructed by measuring the thickness of the hull, deck, keel, frames, and longitudinal structure of the fishing boat. The collision model is carried out with an impactor in the form of a mooring pole during extreme weather with a wave height of 6 meters and wind speeds 30 knots. Variations in velocity and frame spacing as in actual conditions are modeled to obtain differences in deformation, absorption energy values, and plasticity of boat construction due to collisions. The collision speed of 30 and 20 knots are set on the extreme weather conditions, while the collision speed of 7 knots is set on operating speed. Frame spacing of 0.5 and 0.6 meters is built according to the boat's frame spacing in the field. Computer simulation is carried out using application software ANSYS Research License. The fishing boat material used is mahogany wood with tested by using impact test with a toughness value of 39.1 kJ/m2. Based on the simulations results, the impact velocity has an effect deformation wider crash area and hull stress value. The speed of the ship collision was 7 knots, the collision did not damage the hull, but the construction failed at speeds of 20 and 30 knots. The closer of frame spacing, the higher collision performance of structure to withstand impact are indicated by the higher energy absorption. At a ship collision speed of 30 knots, the absorption energy of the construction at 0.5-meter frame spacing is 49.8 kJ, greater than 0.6-meter frame spacing with a value of 29.6 kJ
Development of simple kits (SK) refraction of light using photodiode sensors for student understanding
Authors: Wibowo Firmanul Catur , Maemunah Ade Nur , Nasbey Hadi , Costu Bayram , Prahani Binar Kurnia , Permana Niki Dian , Darman Dina Rahmi , Samsudin Achmad 
Published: March 2023

Students' understanding to learn science on the concept of light refraction is experiencing serious problems because of the unobservable of light particles. The research object to be resolved in this study is to improve the concept of light refraction using a photodiode sensor. The problem to be solved in this research is to develop a Simple Kit (SK) Refraction of Light (RoL) using a photodiode sensor for students' understanding of concepts. The research method for making SK RoL using photodiode sensors using ADDIE, which consists of the first stage, analysis by analyzing the needs of SK RoL products using photodiode sensors to be developed. Second, the SK RoL design uses a photodiode sensor. Third, Development is developing SK RoL Using Photodiode Sensors. Implementation of the Fourth RoL Decree Using Photodiode Sensors to see student understanding of 74 students from tertiary institutions in one of the provinces in Indonesia. Fifth, Evaluation by revising the product at each stage of SK RoL development. SK RoL product research results include Green Laser, Photodiode sensor, Angle Arc, Display Module and Displayed Data, Arduino Uno R3 Atmega 328, Medium Container and Programs Using Arduino Software. The characteristics of the SK ROL results show that the SK RoL based on the Photodiode Sensor developed can be used as a physics learning medium because it can visualize the unobservable concept of light refraction and increase students' understanding of the concept of light refraction because of the nature of the particles which are difficult to understand by using a green laser which is passed through a photodiode sensor medium and Arduino can be visualized in a real way. SK RoL can work optimally in a room where the light is not too bright or requires a room that is a bit dark so it is possible to observe the laser beam. SK RoL, as a physics learning medium, can be used to increase students' understanding of the concept of light refraction. The implications of developing SK RoL can be used as a learning medium to attract students' interest in learning, support the learning process, and help make it easier for students to understand abstract physics concepts
Development of mesoporous activated carbons derived from brewed coffee waste for CO2 adsorption
Authors: Putra Negara Dewa Ngakan Ketut , Widiyarta I Made , Suriadi I Gusti Agung Kade , Dwijana I Gusti Komang , Budiana Penindra I Made Dwi , Tenaya I Gusti Ngurah Putu , Sukadana I Gusti Ketut , Ferdinand Anton Saladin 
Published: March 2023

The primary cause of rising CO2 concentrations in the atmosphere is the use of fossil fuels in motor vehicles and factory activities in industry. CO2 levels in the atmosphere can be controlled and reduced by using low-carbon energy and capturing and storing CO2. One widely used way for CO2 capture and storage is adsorption method. This method necessitates the use of an adsorbent, one of which is activated carbon. In this study, brewed coffee waste was converted into activated carbons, characterized, and tested for carbon dioxide adsorption. Brewed coffee waste was dehydrated at 105 ºC for an hour before being carbonized at 550 °C and activated at 670, 700, and 730 °C, with a 200-ml/min nitrogen injection during activation. Activated carbons with activation temperatures of 670, 700, and 730 °C were denoted as AC-670, AC-700, and AC-730, respectively. A series of TGA, SEM, and adsorption isotherm tests were used to determine the proximate components, surface morphology, and surface structure of the activated carbons produced. To assess the adsorption capacities of activated carbon on CO2, the gravimetric CO2 adsorption isotherm method was used. According to the findings of the study, increasing activation temperatures cause variable properties in activated carbon. When using an activation temperature of 700 °C, the most appropriate properties of activated carbon can be obtained. It has 425.843 m2/g specific surface area, 0.345 cm3/g pore volume, 3.423 nm pore diameter, 235.628 cm3/g nitrogen adsorption capacity, and 4.183 mmol/g CO2 adsorption performance. This study provided a simple way converting brewed coffee waste into activated carbon with excellent performance for CO2 adsorption
Evidence for abundant organic matter in a Neoarchean banded iron formation
Authors: Peng Zidong , Nan Jingbo , Zhang Lianchang , Poulton Simon W. , Zhou Junlie , Yuan Yuan , Ta Kaiwen , Wang Changle , Zhai Mingguo 
Published: March 2023

Abstract
Microbial Fe(II) oxidation has been proposed as a major source of Fe minerals during deposition of banded iron formations (BIFs) in the Archean and Proterozoic Eons. The conspicuous absence of organic matter or graphitic carbon from BIFs, however, has given rise to divergent views on the importance of such a biologically mediated iron cycle. Here, we present mineral associations, major element concentrations, total carbon contents and carbon isotope compositions for a set of lower amphibolite-facies BIF samples from the Neoarchean Zhalanzhangzi BIF in the Qinglonghe supracrustal sequence, Eastern Hebei, China. Graphite grains with crystallization temperatures (~470 °C) that are comparable to that predicted for the regional metamorphic grade are widely distributed, despite highly variable iron (12.9 to 54.0 wt%) and total organic carbon (0.19 to 1.10 wt%) contents. The crystalline graphite is interpreted to represent the metamorphosed product of syngenetic bio-mass, based on its co-occurrence with apatite rosettes and negative bulk rock δ13Corganic values (–23.8 to –15.4‰). Moreover, the crystalline graphite is unevenly distributed between iron- and silica-rich bands. In the iron-rich bands, abundant graphite relicts are closely associated with magnetite and/or are preserved within carbonate minerals (i.e., siderite, ankerite, and calcite) with highly negative bulk rock δ13Ccarb values (–16.73 to –6.33‰), indicating incomplete reduction of primary ferric (oxyhydr) oxides by organic matter. By comparison, only minor graphite grains are observed in the silica-rich bands. Normally, these grains are preserved within quartz or silicate minerals and thus did not undergo oxidation by Fe(III). In addition, the close association of graphite with iron-bearing phases indicates that ferric (oxyhydr)oxides may have exerted a first order control on the abundance of organic matter. Combined, the biological oxidation of Fe(II) in the oceanic photic zone and subsequent burial of ferric (oxyhydr)oxides and biomass in sediments to form BIFs, suggests that a BIF-dependent carbon cycle was important in the Archean Eon. Although significant re-adsorption of phosphorus to ferric (oxyhydr)oxides and the formation of authigenic phosphate minerals at the sediment-water interface would be expected, oxidation of biomass in BIFs may have recycled at least a portion of the P (and other nutrients) released from reactions between organic matter and ferric (oxyhydr)oxides to the overlying water column, potentially promoting further primary productivity.
Assessment of a hybrid technology for liquid fuel dimethyl aminoethyl azide wastewater treatment
Authors: Aqaei Mohadeseh , Pakdehi Shahram G. 
Published: March 2023

Abstract
Dimethyl aminoethyl azide (DMAZ) is a liquid fuel in the space industry. Although this fuel is non-carcinogenic, its wastewater suffers from some hazardous pollutants, such as sodium azide (NaN3). A hybrid process of coagulation–flocculation and chemical reaction with nitrous acid was applied for the wastewater treatment. The Taguchi method was used for the process optimization. Coagulant concentration, rapid mixing intensity, duration time, CAMP number and settlement time were found to be effective parameters for the efficiency of the former process. Turbidity and total suspended solids (TSS) of the wastewater were used to track the removal efficiency in the first stage. The complete removal efficiency was achieved. In the latter process, NaN3 was removed using a reaction with nitrous acid. pH of the wastewater was optimized as the controlling factor in the second process. Biochemical oxygen demand (BOD), chemical oxygen demand (COD) and NaN3 removals of 98.9, 98.2 and 96.3% were obtained under the optimum conditions, respectively. As a result, a reduction of 91.9% in turbidity, 98.5% in TSS, 98.5% in BOD, 98.1% in COD and 96.7% in NaN3 concentration were observed in the output of the wastewater.