bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of Load Frequency Control for Two-Area Modern Power Systems Involving Renewable Energy Sources Using a Novel Cascade Controller
Authors: Duman Serhat , BALCI Yunus 
Published: September 2023

Abstract
Recently, the importance of frequency and voltage stability in interconnected power systems has been raising with increasing energy demand and participation of renewable energy sources (RESs) in electric power systems. In this context, high quality, reliable, continuous and stable electrical power transmission should be made to the consumer in modern power systems. The incongruence between the power generation and load demand in sudden load changes in power systems cause undesirable oscillations in the frequency and tie-line power between generation areas. The controllers used to suppress these oscillations in load frequency control (LFC) must operate satisfactorily in line with the desired system criteria. This study proposed a powerful cascade controller structure based on the combination of the PID and FOPID controllers with fractional derivative filters (PID-FOPIDFF) to meet the desired system criteria. Moreover, the parameters of the proposed controller structure are adjusted using Slime Mold Algorithm (SMA), Gradient-based optimizer (GBO), Hunger games search (HGS), weighted mean of vectors (INFO), and RUNge Kutta optimizer (RUN) algorithms. The SMA method offers a percentile decrease of 48.5399%, 119.0483%, 155.0614%, and 200.5109% in comparison to the outcomes of the HGS, GBO, INFO, and RUN algorithms for the ITAE value utilized as the objective function in the optimization process of the proposed PID-FOPIDFF controller. The performance of the proposed controller was compared with the performances of seven different controllers most used in the literature. The PID-FOPIDFF controller, which can respond quickly and dampen frequency and power oscillations, guarantees that system performance will be improved. Three different test systems including combinations of photovoltaic (PV), fuel cell (FC), electrolyser, thermal, hydropower, gas and wind energy systems, and the TCPS from FACTS devices are used to confirm the effectiveness of the method. The simulation results reveal the advantages of the proposed PID-FOPIDFF controller over the commonly used controllers. The robustness of the proposed controller structure is confirmed by the simulation study findings, which included various load and system parameter changing scenarios.
Light pollution and habitat fragmentation in the grey mouse lemur
Authors: Tallec Thomas Le , Hozer Clara , Perret Martine , Théry Marc 
Published: September 2023

Abstract
Light pollution, by changing organisms’ behavior, affects locomotion, migration and can ultimately fragment the habitat. To investigate the effects of light pollution on habitat fragmentation, we conducted an experimental study on a nocturnal and photosensitive primate, the grey mouse lemur (Microcebus murinus). Twelve males were housed individually in an apparatus with two cages connected by two corridors, opaque and transparent. During 4 nights, the transparent corridor was illuminated by specific light intensities: 0 lux, 0.3 lux, 20 lux and 51.5 lux corresponding respectively to total darkness, full moon, minimal intensity recommended by the European standard EN-13201 on public lighting, and to light pollution recorded in an urban area. Each night, general activity, use of corridors and cage occupancy were recorded using an infrared camera. For the first time in a nocturnal primate, results demonstrate that light pollution changes the preference of use of corridors, modifies the locomotor pattern and limits the ability of animals to efficiently exploit their environment according to a light intensity-dependent relationship. However, results indicate that a dark corridor allows partial compensation partly preserving general activities. This study highlights the necessity to consider light pollution during the implementation of conservation plans and the relevance of nocturnal frames.
Fact-checking in Evidence-Based Medicine in Physiotherapy undergraduate students.
Authors: Perpiñá-Martínez Sara , Álvarez-Comino María José , Quintana-Alonso Raúl 
Published: September 2023

Abstract
Introduction
Fact-checking is an innovative teaching methodology that allows training professionals who are critical of the information they receive, and comparing data to determine its validity by instilling in them an evidence-based work methodology, thus benefiting both their clinical practice and the quality and safety of the care they provide to their patients. The objective was to determine the effect of a training activity based on fact-checking and developed using learning-by-doing methodology in knowledge acquisition, research skills, and comparison of information by physiotherapist students, as well as to determine their satisfaction with the training activity.
Methods
Teaching innovation study carried out through a learning methodology based on learning-by-doing on fact-checking in physiotherapy. Twenty-five students participated, randomly divided into working groups. They selected and analysed the methodological quality of a treatment technique published in a scientific article and reproduced it under the same conditions. Then, they applied critical reasoning to the results obtained. The application and reasoning of the scientific method were assessed quantitatively, and the student’s understanding of the training activity was assessed qualitatively.
Results
The average grade obtained was 8.29. Satisfaction with the activity was 4.16 out of 5, highlighting the application to professional activity with 4.17/5. Finally, students highlighted the learning received on properly conducting scientific research.
Conclusion
A training action based on fact-checking and developed through learning-by-doing allows students to acquire the skills to assess the information they receive on physiotherapy critically and helps them to make better clinical decisions, always based on quality scientific evidence.
Green Credit Policy and Labor Investment Efficiency: Evidence from China
Authors: Liu Ying , Wang Junqiu , Xu Canyu 
Published: September 2023

Abstract
Green finance plays a crucial role in driving green development. By leveraging the implementation of the "Green Credit Guidelines" as a quasi-natural experiment in 2012, our study provides compelling evidence that this green credit policy enhances the efficient investment in labor. Our mechanism analysis indicates that the positive impact primarily stems from the upgrading of human capital and the mitigation of agency conflicts. Moreover, we find that the effect of the green credit policy on the efficient investment in labor by green credit-restricted firms is more pronounced when these firms face robust environmental law enforcement and operate with low labor intensity. Additionally, the enhanced investment in labor demonstrates a significant positive influence on future enterprise value. Overall, our findings underscore the significant improvement in corporate labor investment efficiency resulting from the successful implementation of the “Green Credit Guidelines”.
JEL: G30, G38, J21
Mature intramedullary cystic teratoma in an adult female: a case report and literature review
Authors: Zhang Qinyang , Liu Xuepeng , Zhao Tianyu , Li Rulin , Qian Zhanyang , Li Haijun 
Published: September 2023

Abstract
Background: To describe a rare case of mature intramedullary cystic teratoma.
Case presentation: A 51-year-old female with a 10-year history of progressive low back pain presented with a 9 × 15 mm circular tumor adjacent to L1 on preoperative magnetic resonance imaging (MRI). The lesion was successfully removed by T12–L2 laminectomy and nail–rod fixation, and the diagnosis was subsequently confirmed by histopathological examination. At 6-month follow-up, right lower limb numbness and pain were reduced.
Conclusions: Mature intramedullary cystic teratoma size, morphology, and location relative to peripheral nerves can be revealed by MRI for preoperative planning. Surgical resection with nail–rod fixation is the best treatment for multilevel lesions.
The relationship between cardiovascular diseases and the family history of Alzheimer’s disease: results from NHANES (1999-2004)
Authors: Liu Haiyue , You Mingming , Cao Nannan , Li Feng , Zhu Bo , Ma Xiaobo , Zheng Gangsen , Zheng Yanqing , Wang JiaYi , Yang Wanzhen , Zheng Yixuan , Fang Lili , Huang Chaoyang , Liu Zuheng , Hong Guolin 
Published: September 2023

Abstract
Patients with cardiovascular diseases (CVDs) have a notably high Alzheimer’s disease (AD) risk in the previous finding. Both CVDs and AD are genetic related disorders. While seldom data concerning the risk of CVDs in individuals with AD family history. The present study aimed to examine the relationship between CVDs and family history of AD. A total of 15019 participants were enrolled and analyzed. Logistic regression analysis indicated that individuals with AD family history had 0.173 higher odds of CVDs than those without AD relatives (OR = 1.173 (1.029-1.338), p < 0.05). The odds ratio of CVDs in the adjudged model was 1.184 (95%CI 0.987-1.421) for individuals with maternal line family history of AD after taking into account age, gender, BMI, race, education and family income. AD family history was positively associated with CVDs, while maternal origin AD family history is more likely to be a risk factor for CVDs than paternal origins. Further prospective studies are needed to confirm the relationship between AD family history and CVDs.
Effect of Vanillin on Emotional Stress and Pain-Related Behaviours Induced by Experimental Tooth Movement in Rats
Authors: Wu Tingting , Wu Wenning , Jin Shiyu , Zhang Qunyan , Ding Siqi , Wu Chuan , Zheng Xiuyun , Fu Chunfeng , Han Quancheng , Liu Xiaoyu 
Published: September 2023

Abstract
Background
Pain is a common symptom of orthodontic treatment. Therefore, this study aimed to determine the effect of vanillin on emotional stress and pain-related behaviours induced during tooth movement by observing the behaviours of orthodontic rats and to provide a therapeutic basis for the discomfort caused by orthodontic treatment.
Methods
A 75 g orthodontic force was applied via an orthodontic appliance to the left maxillary incisors and first molars of 200–250 g male Sprague-Dawley rats. The rats were then administered vanillin in three different ways on days 1, 2, 3, 5, and 7 (via gavage, sniffing, or coating around the gingiva of the orthodontic teeth). Behaviour was evaluated at each time point in an open field based on the number of lines crossed in the first 30 s and 5 min, the number of lines crossed to the centre, the rearing time, the facial grooming time, and the Resistance-to-Capture scores.
Results
In the experimental orthodontic stimulation, the rats showed anxious, pain-related behaviours such as nervousness, rearing, decreased interest in exploring their surroundings, and reduced mobility. Conversely, in orthodontic rats administered vanillin, anxiety and pain-related behaviours were alleviated, and their mobility was restored. Furthermore, each administration method has the advantages of reducing pain and increasing activity.
Conclusion
This study revealed that three vanillin administration methods have advantages in alleviating anxiety and pain during experimental tooth movement, which can serve as a reference for clinicians to treat patients with orthodontic pain.
Theoretical Basis Validation and Oxidative Stress Markers for Cancer Prevention Clinical Trials of Aspirin
Authors: Mutoh Michihiro , Hamoya Takahiro , Tomono Susumu , Miyamoto Shingo , Fujii Gen , Wakabayashi Keiji 
Published: September 2023

Abstract
Aspirin, a nonsteroidal anti-inflammatory drug, has been proven effective in a clinical trial of carcinogenesis blockade. However, various modes of action have been reported for these effects. Thus, in this study, we aimed to present reasonable mode of actions as a proof of concept for human trials, especially trials for patients with familial adenomatous polyposis (FAP). Aspirin treatment at 1,000 ppm inhibited intestinal tumorigenesis in FAP model Min mice. As a mode of action, aspirin regulated β-catenin signaling, inflammation, and oxidative stress both in vivo and in vitro. Furthermore, we examined novel markers predictive of cancer prevention based on liquid biopsy. Here, we demonstrated that aspirin reduced the levels of reactive carbonyl species in the serum of Min mice. These data are expected to be of use for proof of concept of aspirin human trials and for the prediction of aspirin efficacy.
Assessment of hospital arrival time and associated factors of patients with acute myocardial infarction (STEMI) to introduce thrombolytic therapy at Jimma Medical Center, Jimma, Ethiopia
Authors: Tukeni Kedir Negesso , Bejiga Yonas Damtew , Abera Eyob Girma , Asefa Elsah Tegene 
Published: September 2023

Abstract
Background
Acute cardiovascular emergencies, including ST-segment elevation myocardial infarction (STEMI) and acute ischemic stroke, are common conditions requiring timely medical intervention. Thrombolytic therapy is an important treatment option for these conditions, although its effectiveness depends on prompt hospital arrival. This study aimed to assess the arrival time and associated factors in patients with ACS-STEMI at the Jimma Medical Center, with the objective of determining the need and applicability of thrombolytic therapy.
Methodology
: This hospital-based cross-sectional study was conducted at the Jimma Medical Center between September 1st and January 30, 2023. All patients diagnosed with ACS-STEMI during the study period were included. Data were collected using structured questionnaires and were entered into Epi-data version 3.1 for analysis. Chi-square tests and logistic regression models were used to examine the relationships between the variables.
Results
Among 63 patients admitted with ACS-STEMI, males accounted for 57.1%, and 42,9% of all admissions were in the 55—64 age group. More than two-thirds of the participants did not attend formal education, and hence could not read and write, and most (68%) used public transport to reach the medical center. Most participants had a very low monthly income of less than 50 USD. Approximately 62% of the study participants arrived at the Medical Center 12 h after the onset of chest pain (average time of arrival was approximately 33 h and 21 min). The sudden onset of symptoms and proximity to the Medical Center (within 5 km) were related to a shorter time of arrival, while those with diabetes mellitus had a longer time of arrival.
Conclusion
The time of arrival was longer in the patients with ACS-STEMI. Level of education, misinterpretation of symptoms, and lack of public health insurance were the major correlates of prehospital delays. This emphasizes the need to improve public health literacy, health insurance coverage, and the availability of standby emergency public ambulances, which shortens the time-to-needle and leads to early medical intervention that reduces morbidity and mortality, while improving survival and quality of life.
The yield of early-pregnancy HOMA-IR index for predicting gestational diabetes mellitus in different BMI and age groups
Authors: Hashemipour Sima , Zohal Mahnaz , Modarresnia Leila , Kolaji Sepideh , Panahi Hamidreza , Badri Milad , Chopani Sarah Mirzaeei , Kelishomi Sara Esmaeili , ghassemi Amirabbas , Ghafelehbashi Seyyed Hamidreza 
Published: September 2023

Abstract
Background: Gestational diabetes (GDM) is a highly prevalent disorder with maternal and neonatal complications. Early prediction of GDM can be beneficial for lifestyle modifications to prevent GDM.
Method: This study is part of the Qazvin Maternal and Neonatal Metabolic Study (QMNMS) in Iran in which pregnant women with gestational age ≤14 weeks were enrolled and followed until delivery to investigate the risk factors for maternal and neonatal complications. The predictive value and best cut-off of early-pregnancy Homeostasis of Model Assessment -Insulin Resistance (HOMA-IR) to predict GDM in BMI and age categories were evaluated using logistic regression analysis and receiver operating characteristic analysis, respectively.
Results: GDM was developed in 16.7% of 772 participants who completed the study. In the logistic regression analysis, the third HOMA-IR tertile was independently associated with 3.7 times higher GDM development (95% CI:1.9-7.3, P<0.001). Despite the high prevalence of GDM in advanced maternal age (GDM rate=30.9%), HOMA-IR had no association with GDM occurrence in this high-risk group. In both normal BMI and overweight/obese groups, HOMA-IR was a moderate predictor of GDM development (AUC=0.638, P=0.005 and AUC=0.622, P=0.008, respectively). However, the best cut-off for predicting GDM was 2.06 (sensitivity 67.5%, specificity 61.1%) in normal BMI and 3.13 (sensitivity 64.6%, specificity61.8%) in overweight/obese BMI.
Conclusion: The present study revealed the necessity of considering the baseline GDM risk group when using the HOMA-IR index to predict GDM. Using lower cut-offs is more accurate for women with a normal BMI. In the advanced maternal age, there is no yield of HOMA-IR for predicting GDM.
Effect of body fat mass loss on prognosis of radical resection for pancreatic ductal adenocarcinoma based on bioelectrical impedance analysis
Authors: Shibata Yoshiyuki , Sudo Takeshi , Tazuma Sho , Sada Haruki , Tanimine Naoki , Shimada Norimitsu , Tazawa Hirofumi , Suzuki Takahisa , Onoe Takashi , Shimizu Yosuke , Tashiro Hirotaka , Yamaguchi Atsushi , Takahashi Shinya 
Published: September 2023

Abstract
Background
Few reports have performed a prognostic analysis based on bioelectrical impedance analysis in patients with radical resection of pancreatic ductal adenocarcinoma (PDAC), and its usefulness in prognostic analysis remains unclear. This study aimed to evaluate body composition changes in patients undergoing radical resection for PDAC and analyze its impact on prognosis.
Methods
The medical records of radical resection for patients with PDAC were retrospectively reviewed, and the parameters of body composition, including body weight, skeletal muscle mass, body fat mass (BFM), and extracellular water-total body water ratio, from preoperatively to 12 months postoperatively, for each surgical procedure were measured based on direct segmental multifrequency bioelectrical impedance analysis with an InBody 770 (InBody Inc., Tokyo, Japan) device. The clinicopathological and prognostic factors were analyzed.
Results
Among 79 patients who underwent radical resection for PDAC, 36 (46%), 7 (8%), and 36 (46%) underwent pancreatoduodenectomy, total pancreatectomy, and distal pancreatectomy, respectively. The multivariate overall survival analysis demonstrated that BFM loss percentage at 1 month postoperatively ≧ 14% (p = 0.021), lymph node metastasis (p = 0.014), and non-adjuvant chemotherapy (p < 0.001) were independent poor prognostic factors. Multivariate analysis revealed that preoperative BFM < 12 kg and preoperative albumin < 3.5 g/dL were independently associated with BFM loss percentage at 1 month postoperatively ≧ 14% (p = 0.016 and p = 0.047, respectively).
Conclusions
Loss of BFM in the early postoperative period may have a poor prognosis in radical resection of PDAC.
Comparing MMSE and RUDAS in detecting cognitive impairment: A population-based study from Punjab, North India
Authors: Yadav Neha , Chaudhary Vineet , saraswathy Kallur Nava , Dhamija Rajinder Kumar , Devi Naorem Kiranmala 
Published: September 2023

Abstract

Background
The Mini Mental State Examination (MMSE) and Rowland Universal Dementia Assessment Scale (RUDAS) are commonly used tools for screening cognitive impairment (CI) in epidemiological research globally. However, discrepancies have been noted in their ability to detect CI. Hence, present study was carried out to understand the test performance of MMSE and RUDAS among adults of a homogeneous group of rural Punjab, North India.
Methods
A total of 956 adults aged 18–75 years of both sexes, were recruited from the Jat Sikh community in rural Punjab. Sociodemographic (age, sex, marital status, employment status, annual income, family size) and lifestyle variables (smoking behavior, alcohol intake, and diet pattern) were collected using pretested and modified interview schedules. CI screening was performed using MMSE and RUDAS tools. Statistical analysis was conducted using SPSS software version 22.
Results
The overall prevalence of CI was found to be 40.3% and 27.8% using MMSE & RUDAS respectively. MMSE and RUDAS demonstrated a moderate correlation (Spearman correlation coefficient = 0.43) and a moderate agreement (Kappa value = 0.42). The highest concordance (79.1%) between the two tools in detecting CI was observed among elderly participants ( > = 60 years). Furthermore, in sociodemographic and lifestyle categories, both tools showed relatively higher concordance, with no discrepancies among the elderly group.
Conclusions
MMSE and RUDAS have shown a moderate correlation and agreement among the studied group. However, relatively higher concordance was observed among elderly individuals. Hence, both the screening tools should primarily be used for the elderly group. Whereas, modifications maybe needed to administer them on the younger group.
Differentially Expressed Genes and Pathways between Reversible and Irreversible Pulmonary Arterial Hypertension Associated with Congenital Heart Disease Investigated by Bioinformatics Analysis in Rat Model
Authors: Zeng Haowei , Lan Beidi , Liu Xiaoqin , Xie Hang , Zhang Yushun 
Published: September 2023

Abstract
Background
Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is one of the common types of PAH. Although the treatments of PAH–CHD are greatly advanced, it is still characterized by a poor prognosis, especially in its irreversible stage. The molecular mechanism underpinning the transition from the reversible stage to the irreversible stage is not well established.
Methods and results
GSE149899 was downloaded from Gene Expression Omnibus database, which is a dataset harvested from rat PH model induced by monocrotaline together with aortocaval shunt ((control (n = 5), reversible (n = 12), irreversible (n = 6)). R software was used to determine 252, 445, and 880 differentially expressed genes (DEGs) between the control group and the reversible PAH-CHD, the control group and the irreversible PAH-CHD, the reversible and irreversible PAH-CHD, respectively. Furthermore, we analyzed the biological functions of these DEGs. We concluded that common DEGs between reversible and irreversible PAH-CHD mainly enriched in the cell cycle, the p53 signaling pathway. The unique DEGs of reversible PAH-CHD involved in cell cycle, base excision repair. DEGs exclusively found in irreversible PAH-CHD were associated with complement and coagulation cascades, ECM-receptor interaction, focal adhesion, PI3K-Akt signaling pathway. Additionally, The P53 signaling pathway, ferroptosis, PI3K-Akt signaling pathway, IL-17 signaling pathway, cell cycle, complement and coagulation cascades were up-regulated both in reversible and irreversible groups, but up-regulation of the PI3K-Akt signaling pathway, cell cycle were more pronounced in the reversible group, whereas ferroptosis and complement and coagulation cascades was more pronounced in the irreversible group. The TNF signaling pathway, cellular senescence, and the AGE-RAGE signaling pathway were exclusively up-regulated in the reversible group, while the renin-angiotensin system was up-regulated and the AMPK signaling pathway was down-regulated exclusively in the irreversible groups.
Conclusions
The distinguishing pathways and hub genes between reversible and irreversible PAH-CHD may be attributable to the loss of reversibility of PAH-CHD in the end stages, and may cast new light on future research.