bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Antioxidant and Ex Vivo Anticataract Activity of Hydroalcoholic Extract of Cordia obliqua Willd
Authors: Shrivastava Arpit , Jain Harshita , Mishra Shikha , Khare Basant , Jain Prateek Kumar 
Published: January 2023

Cordia obliqua has a long history of use in the treatment of cataract and other eye-related problems in Indian traditional medicine. High oxidative stress is one of the major underlying causes of cataract which results in the precipitation of natural protein present in the lenses with aging. This research has been carried out to determine the anti-cataract activity of Cordia obliqua by performing various antioxidant techniques such as 1,1-diphenyl-2-picrylhydrazyl, hydrogen peroxide, ABTS radical cation and Ferric reducing antioxidant potential studies in oxidative stress–induced ex vivo cataract model. Results of the study conducted in the hydroalcoholic extract of leaves of Cordia obliqua revealed the presence of various phytoconstituents such as alkaloids, phenols, flavonoids, etc. Total phenol and total flavonoid content was found to be 53 ± 3.21and 26.12 ± 2.54% respectively, which revealed that the plant contains a good amount of these compounds and hence possesses good antioxidant activity. Furthermore, IC50 values obtained from all the methods gave strong evidence regarding the antioxidant potential of this plant. Anti-cataract activity was also investigated using goat eye lenses and promising results were obtained which speak voluminously about its anti-cataract potential and support its well-prescribed use. Results obtained with this study clearly supported the significant antioxidant potential and anticataract activity of this plant. Further, this plant demands great attention for the development of suitable novel dosage forms for the effective treatment of cataract.
Keywords: Cordia obliqua, cataract, High oxidative stress
Design, Development and Characterization of Hyaluronic Acid Based pH Sensitive Liposomal In Situ Gel for the Treatment of Keratoconjunctivitis Sicca
Authors: Nagalakshmi S , Teshini Suthahar , Shoba E , Madhavan Shyam , Shilpa Suresh , Sintinya S. 
Published: January 2023

The recent advances in ocular drug delivery have been successful in surpassing conventional therapy, owing to its considerable limitations. This study aims to develop and optimize in-situ liposomal ocular system to design once-daily liquid preparation to treat Keratoconjunctivitis sicca. Liposomes of Hyaluronic acid were prepared using soya lecithin by a thin film hydration method. Eight trial formulations were made by keeping drug as fixed ratio and varying the concentration of cholesterol and soya lecithin. The optimized formulation was selected for the formulation of liposomal in-situ hydrogel. Optimization was carried out by Central Composite Design (CCD) studying the factors, amount of cholesterol and soya lecithin and its effects on the responses, % In- vitro drug release (R1) and Percent Entrapment Efficiency (% EE) (R2). The best predicted model for R1 was the Quadratic model and, for R2 was Two-Factor Interaction model (2FI) without any significant lack of fit. Optimum formulation was found to be at 1:1:4 (drug: cholesterol: soya lecithin) showed sustained drug release of 31.28% in 8 hours with highest %EE of 47.36%. Liposomal in-situ gel preparation retained better stability throughout the study period when stored at refrigerator temperature and displayed prolonged action (76.44%) when compared to liposomal formulation (68.72%).
Keywords: Liposomes, Hyaluronic acid, Optimized formulation, CCD, sustained drug release, in-situ hydrogel.
Traditional Herbal Remedies from Algeria for Treating Digestive Disorders
Authors: Djahra Ali Boutlelis , Lmhanat Iman , Benkaddour Mounia , Benkherara Salah , Laib Ibtissam , Benine Chaima 
Published: January 2023

Due to their efficiency in many treatments, the employment of herbal remedies has retained its importance for leading a human life. Traditional knowledge is passed from one generation to the next, which is protected. This research aimed to analyze traditional herbal remedies used in treating digestive disorders by El-Oued people (Southeastern Algeria). The research was conducted from September 2021 to June 2022. One hundred individuals, including thirty plant vendors, were selected from different regions. Personal interviews and questionnaires were employed to collect the data. SPSS version 20 and Microsoft Office Excel 2007 were used to organize the data and conduct the descriptive statistics analysis. This investigation enabled the discovery of 40 species in 16 families and different genres. Lamiaceae, with 22.5 % plants, were the most used sources for the treatment, and 54 % of herbs were spontaneous species. The use of seeds at 21 %, dry parts at 92 % and infusion method at 48 % was most commonly used in herbal remedies preparations. The participants cited Trigonella tibetana, Juniperus communis, and Punica granatum as sources of digestive disorders treatment. El-Oued region has an extremely high number of herbal remedy species, which suggests that the region's traditional medicine serves as a source of knowledge about medicinal plants for treating digestive disorders and illnesses associated with them.
Keywords: Herbal remedies, Digestive disorders, Medicinal plants, Interviews.
Radioligand therapy with <sup>177</sup>Lu-DOTA-PSMA in metastatic castration-resistant prostate cancer. Pharmacokinetics, safety, antitumour efficacy
Authors: Krylov V. V. , Legkodimova N. S. , Kochetova T. Yu. , Petriev V. M. , Sigov M. A. , Tishchenko V. K. , Pronin A. I. , Shurinov A. Yu. , Petrosyan K. M. , Spichenkova O. N. , Karyakin O. B. , Biryukov V. A. , Stepanenko V. F. , Vlasova O. P. , Shegaj P. V. , Ivanov S. A. , Kaprin A. D. 
Published: January 2023

INTRODUCTION: The results of studies of clinical potential of a new domestic radiopharmaceutical 177Lu-DOTA-PSMA in patients with metastatic castration-resistant prostate cancer are presented in this article.OBJECTIVE: The pharmacokinetics, safety and tolerability of radiopharmaceutical were studied. Tolerability of increasing activities — 5.0, 7.5 and 10.0 GBq was investigated.MATERIALS AND METHODS: The study included 12 patients with metastatic castration-resistant prostate cancer, who progressed after previous treatment. The first 4 patients was treated by 5 GBq of 177Lu DOTA-PSMA, the next 4 patients of the second group was treated by 7.5 GBq, and the 4 patients of the third group was treated by 10 GBq. Radiopharmacokinetics was studied by whole-body scintigraphy, SPECT/CT, blood and urine radiometry. The radiation-absorbed dose (RAD) of metastases and organs at risk was studied by clinical dosimetry. Safety assessment also was studied by hematological status. All patients was taken a complete blood count, a biochemical blood test before course of therapy treatable and during the case study.RESULTS: Study data showed high accumulation of 177Lu-DOTA-PSMA the in pathological focus, the distribution in the body conformed to the previous data of PET/CT study. Blood radiometry showed that 177Lu-DOTA-PSMA rapidly excreted from the bloodstream (during the first hours after injection). Urine radiometry showed that, more than half of the injected dose was excreted during 2 days (from 34.4% to 88.8%).DISCUSSION: During the study was solicited increasing of pain syndrome, dry mouth. Most patients had moderate myelosuppression. Changes in hematological parameters had a transistor character, the adverse event resolved without consequences in 5 week. 4th grade of NCI CTCAE hematological toxicity criteria wasn’t identified. Serious adverse events weren’t identified too.CONCLUSIONS: Radiopharmaceutical demonstrated high affinity for tumor tissue and safety in the clinical use. Data, which demonstrating a high potential anti-tumor efficacy of radiopharmaceutical, were obtained. Dosimetric studies showed radiation safety of work with radiopharmaceutical for the personnel.
Inflammatory Cell Infiltration into Islets without PD-L1 Expression is Associated with the Development of Immune Checkpoint Inhibitor-Related Type 1 Diabetes in Genetically Susceptible Patients
Authors: Kawata Satoshi , Kozawa Junji , Yoneda Sho , Fujita Yukari , Kashiwagi-Takayama Risa , Kimura Takekazu , Hosokawa Yoshiya , Baden Megu Y , Uno Sae , Uenaka Rikako , Namai Kazuyuki , Koh Yoko , Tomimaru Yoshito , Hirata Haruhiko , Uemura Motohide , Nojima Satoshi , Morii Eiichi , Eguchi Hidetoshi , Imagawa Akihisa , Shimomura Iichiro 
Published: January 2023

<p> </p>
<p>Immune checkpoint inhibitors (ICIs) could cause type 1 diabetes (T1D). However, the underlying mechanism remains unclear. We immunohistochemically analyzed pancreatic specimens from 3 cases with ICI-related T1D, and their histopathological data were compared those from 3 patients who had received ICI therapy but did not develop T1D (non-T1D) and 7 normal glucose-tolerant subjects as controls. All ICI-related T1D patients had susceptible HLA haplotypes. In ICI-related T1D, the β‐cell area decreased and the α‐cell area increased compared to non-T1D and controls. The number of CD3-positive cells around islets increased in ICI-related T1D and non-T1D compared with controls, while the number of CD68-positive cells around islets increased in ICI-related T1D compared with non-T1D and controls. The expression ratios of PD-L1 on islets decreased in non-T1D and almost completely disappeared in ICI-related T1D, while PD-L1 expression was observed in most cells of pancreatic islets in controls. This study, therefore, indicates that ICI therapy itself could reduce PD-L1 expression on islets in all subjects, which may be related to β cell vulnerability. In addition, we showed that absence of PD-L1 expression on β cells, genetic susceptibility and infiltration of macrophages as well as T lymphocytes around islets might be responsible for T1D onset.</p>
Биорегуляционная терапия постгерпетической невралгии тройничного нерва
Authors: Мамедова Айгюнь 
Published: January 2023

Невралгия тройничного нерва представляет собой очень болезненное
неврологическое состояние с сильными, кратковременными приступами
колющей боли в области лица, вызванное раздражителями. Приступообразная
боль напоминает удар, в одной или нескольких ветвях тройничного нерва. В
дополнение к приступообразным болям некоторые пациенты также имеют
постоянную боль. Невралгию тройничного нерва подразделяют на классическую
и вторичную.
Основным патофизиологическим механизмом при этой болезни является
демиелинизация первичных сенсорных афферентов тройничного нерва в зоне
входа корня. У значительной части больных демиелинизация обусловлена
сосудисто-нервным поражением с такими морфологическими изменениями, как
сдавление корешка тройничного нерва. Однако существуют и другие
этиологические факторы, так как только у половины больных имеются
морфологические изменения. Важные дифференциальные диагнозы включают
вегетативную цефалгию тройничного нерва, посттравматическую или
постгерпетическую боль и другие лицевые боли [ 1,2,3,4].
Терапией первой линии является профилактическое лечение блокаторами
натриевых каналов. Карбамазепин и окскарбазепин являются препаратами
первого выбора для длительного лечения. Терапией второй линии является
нейрохирургическое вмешательство. Учитывая вышеизложенное, оправдана
разработка более эффективных вариантов лечения. В этом плане весьма
перспективным является использование биорегуляционнй терапии [5]
What Marquis de Sade’s Literary Critique Can Teach Us about Entrepreneurship
Authors: Pelly R. Duncan M. , Fayolle Alain 
Published: January 2023

Abstract
No writer has captured the reader’s imagination as vividly as the Marquis de Sade. Per his usual ramblings, he espouses evil via excruciatingly detailed sexual exploits; but, in later writings he is vehemently critical of those who engage in corrosive behavior. In Reflections on the Novel, de Sade provides step-by-step instructions to create repelling, enthralling, and memorable fictional narratives, then stratifies “what not to do” in order to avoid situations that may lead to irreparable physical, mental, and emotional damage in real life. In this same pamphlet, he advocates authenticity in writing and ways to empower the budding Sadist. Moreover, he is unique in this discourse because he deviates from previous writings and speaks directly to the audience. This article deconstructs Reflections on the Novel and it provides unique writing tenets as suggested by de Sade. These precepts are revolutionary because they provide new avenues of research in entrepreneurship.
Ways to neutralize the country-of-origin effect in the emerging market firms international branding1
Authors: Witek-Hajduk Marzanna Katarzyna , Grudecka Anna 
Published: January 2023

Abstract

Paper’s objectives
The purpose of this paper is to examine the ways in which to neutralize the country-of-origin (COO) effect (COE) in the emerging market of firms’ international branding.

Design/methods applied/approach used
A multiple-case study of five companies from European and Asian emerging markets – owners of household appliances brands, with data sourced from in-depth interviews and secondary sources.

Findings
Companies from emerging markets neutralize the genuine COO in their international branding in various ways, for example, by applying brand or sub-brand names that do not refer to the genuine country-of-brand-origin, using slogans in foreign languages or establishing brand alliances with partners from developed countries.

Originality/value
This study offers original insights fostering a better understanding of international branding strategies applied by emerging market companies by identifying the ways they neutralize the COE both at the brand concept level and brand marketing communication tools.
Узкие места в организации рабочих процессов больших суперкомпьютерных центров
Authors: Nikitenko D.A. 
Published: January 2023

Effective output from data centers are determined by many complementary factors. Often, attention is paid to only a few, at first glance, the most significant of them. For example, this is the efficiency of the scheduler, the efficiency of resource utilization by user tasks. At the same time, a more general view of the problem is often missed: the level at which the interconnection of work processes in the HPC center is determined, the organization of effective work as a whole. missions at this stage can negate any subtle optimizations at a low level. This paper provides a scheme for describing workflows in the supercomputer center and analyzes the experience of large HPC facilities in identifying the bottlenecks in this chain. A software implementation option that gives the possibility of optimizing the organization of work at all stages is also proposed in the form of a support system for the functioning of the HPC site.
Эффективная отдача от вычислительных центров определяется множеством взаимодополняющих факторов. Зачастую внимание уделяется только нескольким, на первый взгляд наиболее значимым из них. Например, это эффективность работы планировщика, эффективность использования ресурсов пользовательскими задачами. При этом часто упускается более общий взгляд на проблему: уровень, на котором определяется взаимосвязь рабочих процессов в СКЦ, организация эффективной работы в целом. Упущения на этом этапе способны обесценить любые тонкие оптимизации на низком уровне. В данной работе приводится схема описания рабочих процессов в СКЦ, анализируется опыт крупных СКЦ по выделению наиболее узких мест в этой цепочке, предлагается вариант программной реализации, дающей возможность оптимизации организации работ на всех этапах, в виде системы поддержки функционирования СКЦ.
IMPLEMENTASI MODEL PEMBELAJARAN PROJECT BASED LEARNING (PJBL) UNTUK MENINGKATKAN HASIL BELAJAR MATEMATIKA
Authors: Wahyuddin Wahyuddin , Satriani Sri , Rusdin Nur Qalbi , Nurwidiani Nurwidiani 
Published: January 2023

Tujuan penelitian ini adalah untuk meningkatkan hasil belajar matematika siswa melalui implementasi model PjBL. Penelitian ini merupakan Penelitian Tindakan Kelas model Kemmis &amp; McTaggart dengan tahapan: perencanaan, pelaksanaan tindakan, observasi, dan refleksi yang dilaksnakan sebanyak 2 siklus. Prosedur penelitian dengan tahapan: persiapan, pelaksanaan, analisis data menggunakan analisis data deskriptif kualitatif, dan penarikan kesimpulan. Penelitian dilaksanakan pada kelas XI di salah satu satu sekolah di Kota Makassar. Hasil penelitian menyimpulkan bahwa: 1) Penerapan model pembelajaran <em>project based learning</em> (PjBL) dapat meningkatkan hasil belajar siswa dilihat dari peningkatan hasil belajar matematika siswa mengalami peningkatan dari rata-rata 81,50 pada siklus I meningkat menjadi 88,25 pada siklus II, nilai median meningkat dari 82 menjadi 84, standar eror menurun dari 1,12 menjadi 0,84, nilai terendah 70 meningkat menjadi 78, nilai tertinggi dari 92 menjadi 95, dan rentang skor menurun dari 22 menjadi 17; 2) Distribusi frekuensi dan persentase tingkat capain skor hasil belajar dari siklus I ke siklus II diperoleh bahwa terjadi peningkatan kategori hasil belajar siswa pada kategori tinggi meningkat dari 61,11% menjadi 63,88% dan kategori sangat tinggi juga mengalami peningkatan dari 11,11% menjadi 30,56%; dan 3) Hasil pengamatan proses pelaksaan penelitian diuraikan peningkatan aktifitas siswa dari siklus I ke siklus II bahwa dalam hal kehadiran siswa meningkat dari 83,33% menjadi 97,22%, siswa yang memperhatikan penjelasan guru meningkat dari 76,85% menjadi 92,59%, siswa yang berpartisipasi dalam proyek meningkat dari 75% menjadi 97,22%, siswa yang mempersentasikan hasil pekerjaan proyeknya meningkat dari 25,93% menjadi 43,52%, dan siswa yang bertanya/memberi tanggapan sebesar 21,30% pada siklus I meningkat menjadi 29,63% pada siklus II.
PEMBELAJARAN MATEMATIKA BERBASIS LESSON STUDY DENGAN MENGGUNAKAN MODEL NUMBER HEAD TOGETHER (NHT) PADA MATERI BILANGAN BULAT
Authors: Prihatiningtyas Nindy Citroresmi , Kholifasari Rizqi , Astuti Tri Yulianti , Solong Tendri , Fatmawati Fatmawati , Utami Citra 
Published: January 2023

<p>Penelitian ini bertujuan untuk mendeskripsikan pelaksanaan pembelajaran berbasis lesson study dengan menggunakan model pembelajaran Number Head Together (NHT) pada materi bilanagn bulat. Jenis penelitian ini merupakan penelitian deskriptif kualitatif. Subjek dalam penelitian ini adalah siswakelas VII SMP Negeri 3 Singkawang yang berjuklah 34 orang . Analisis penelitian difokuskan pada kegiatan perencanaan (plan), pelaksanaan (do), dan refleksi (see). Hasil penelitian menunjukkan bahwa secara keseluruhan proses pembelajaran matematika berbasis lesson study dengan model pembelajaran NHT dapat diikuti oleh siswa secara efektif. Sebagian besar siswa berpartisipasi aktif dalam proses pembelajaran. Hasil tes individu sebagai uji pemahaman konsep bilanagn bulat mengalami peningkatan dengan perolehan nilai rata-rata kelas sebesar 83,00 pada siklus I dan perolehan nilai rata-rata kelas sebesar 86,50 pada siklus II. Sementara, hasil respon mahasiswa terhadap proses pembelajaran diperoleh skor rata-rata sebesar 3,20 yang berarti respon siswa</p>
Pemanfaatan Hasil Tangkap Ikan melalui Pelatihan Pembuatan Pempek di Kampung Rempang Cate
Authors: Gustin Oktavianto , Roziqin Arif , Irawan Sudra , Sari Luthfiya Ratna , Lubis Muhammad Zainuddin , Anurogo Wenang , Brajawidagda Uuf , Santiputri Metta , Kushardianto Nur Cahyono , Janah Nur Zahrati , Mufida Mir’atul Khusna , Rokhayati Yeni , Wibowo Ari , Aji Satriya Bayu , Neta Fandy , Pratama Rizki Widi , Rahmi Anis , Ditya Dwiki Novri , Nugraha Rivki Ryan 
Published: January 2023

Jumlah wisatawan dan kemahsyuran pantai pasir panjang hingga saat ini masih dirasa kurang, oleh karena itu perlu di kenalkan ke masyarakat luas tentang keindahan dan hasil laut yang dimiliki di pantai pasir panjang. Pengabdian ini dilakukan untuk sosialisasi manfaat hasil laut melalui Pelatihan pembuatan Pempek di Kampung Pesisir Pasir Panjang.
Pengabdian ini telah kami laksanakan dengan Mitra RW 03 Pasir Panjang Kelurahan Pasir Panjang Kecamatan Rempang Cate pada Hari Jumat tanggal 27 Juli 2018. Hasil Kuesioner Pemateri dengan pengukuran Skala Likert, Peralatan dan Ruangan didapatkan bahwa interpretasi skor hasil pengamatan semuanya bernilai 100% dan masuk dalam kategori interval Sangat Baik yang berarti dinilai sangat Baik oleh 18 Responden. Sedangkan untuk kuesioner konsumsi interpretasi skor hasil pengamatan bernilai 95,556% dan masuk dalam kategori interval Sangat Baik yang berarti dinilai sangat Baik oleh 18 Responden. Hasil monitoring pada tanggal 22 Oktober 2018 didapatkan informasi bahwa terdapat warga yang telah membuat pempek dan berjualan di lingkungan pasir panjang, sedangkan produksi dan penjualan sempat berhenti karena terkendala Hasil tangkap ikan yang terbatas. Hasil kuesioner didapatkan saran terbanyak untuk selanjutnya agar diadakan pelatihan adalah Kerajinan tangan, masukan lainnya agar kegiatan pelatihan berlanjut.
Pembangunan Bilik Pelindung Mesin Pembangkit Listrik di Kelurahan Rempang Cate
Authors: Prasetyo Naufal A , Maskarai Abulija , Wibowo Ari , Asrafi Asrafi , Restu Fedia , Saputra Ihsan , Siregar James , Ismail Muhammad , Arifin Nurul Laili , Pamungkas Nurman , Yogantara Yogantara , Widodo Widodo 
Published: January 2023

Peningkatan pertumbuhan penduduk, berkaitan erat dengan terjadinya kepadatan penduduk yang mempengaruhi aktifitas, perkembangan dalam segi ekonomi, sosial, dan pengembangan fasilitas umum, sehingga tingkat kebutuhan air bersih akan meningkat pula. Namun pada kenyataannya kualitas dan kuantitas sumber air berbanding terbalik dengan peningkatan pertumbuhan penduduk, khususnya di daerah pedesaan.
Keadaan di lapangan telah menunjukkan bahwa ada banyak daerah di pedesaan yang mengalami kesulitan penyediaan air, baik untuk kebutuhan rumah tangga maupun untuk kegiatan umum. Solusi untuk mengatasi keadaan tersebut dapat memanfaatkan pemakaian pompa air baik yang digerakkan oleh tenaga listrik maupun oleh tenaga surya telah lama dikenal oleh masyarakat desa, tetapi masih banyak masyarakat pedesaan yang belum memilikinya. Salah satu penyebabnya adalah terbatas aliran listrik seperti di Kelurahan Rempang Cate, Kecamatan Galang, Kota Batam. Sebagai solusi untuk hal tersebut, dapat digunakan pompa berbasis teknologi water lifting dengan tenaga listrik dari mesin pembangkit portabel.
Pada sisi lain, komponen mesin perlu adanya perlindungan dari cuaca. Kegiatan ini menghasilkan luaran berupa rumah mesin berbahan sheet metal yang dapat melindungan mesin sehingga dapat bekerja dengan baik.