bluuebunny/crossref_metadata_2025_split huggingface dataset:
Перспективи побудови тестів контролю знань персоналу АЕС з використанням штучного інтелекту
Authors: Samoylov V. , Abramovych R. , Taranowski А. 
Published: September 2023

Як один з ключових факторів у сфері ядерної та радіаційної безпеки, підготовка персоналу вимагає постійного підтримування і підвищення ефективності. Свого часу, поєднання прикладних досягнень педагогіки й комп’ютерних наук дозволило значно покращити ефективність навчання й контролю знань персоналу. Та якщо впровадження комп'ютерної системи підготовки та контролю експлуатаційного персоналу з питань ядерної та радіаційної безпеки у межах спільної програми за підтримки Європейського Союзу дозволило перейти від класичної підготовки за допомогою аудиторних занять до використання комп'ютеризованої системи із поетапним проходженням й засвоєнням матеріалу, тестуванням та реєстрацією результатів на об’єктах атомної енергетики, то проблема автоматизації створення тестових завдань донині лишилася невирішеною, втім тепер сучасний рівень техніки це дозволяє.
У межах вирішення цієї проблеми, розглянуто наявний підхід до створення курсів контролю знань в автоматизованій системі комп’ютерного навчання і контролю знань «АСКО», показано придатність цієї системи до створення тестових завдань із застосуванням технологій штучного інтелекту, наведено доступні й готові до використання для цього технології штучного інтелекту, запропоновано підхід до створення тестових завдань у цій системі з використанням цих технологій штучного інтелекту, без зміни самої системи та додаткових витрат.
Очікується, що через підвищення ступеня автоматизації створення тестових завдань покращиться ефективність підготовки персоналу завдяки охопленню контролем знань додаткових сегментів предметної області та змінюваних за змістом сегментів, забезпеченню локалізації створення курсів і контролю знань на рівні окремих об’єктів атомної енергетики та масштабуванню цих процесів, а також оптимізації використання пов’язаних із цим ресурсів.
Identification of Hub Genes and Typing of Tuberculosis Infections Based on Autophagy-Related Genes
Authors: Sheng Yunfeng , Hua Haibo , Yong Yan , Zhou Lihong 
Published: September 2023

Abstract
Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the leading causes of morbidity and death in humans worldwide. Some autophagy genes associated with TB and some miRNAs regulating TB have been found, but the identification of autophagy-related genes in M. tuberculosis remains to be explored. Forty-seven autophagy-related genes differentially expressed in TB were identified in this study by analysis of TB-related datasets in the Gene Expression Omnibus (GEO) and autophagy-related genes in the Human Autophagy Database. The potential crucial genes affecting TB were found through the protein-protein interaction (PPI) network, and the possible pathways affected by these genes were verified. Analysis of the PPI network of miRNAs associated with M. tuberculosis infection and their target genes revealed that hsa-let-7, hsa-mir-155, hsa-mir-206, hsa-mir-26a, hsa-mir-30a, and hsa-mir-32 may regulate the expression of multiple autophagy-related genes (MAPK8, UVRAG, UKL2, and GABARAPL1) alone or in combination. Subsequently, Cytoscape was utilized to screen the differentially expressed genes related to autophagy. The hub genes (GABARAPL1 and ULK2) affecting TB were identified. Combined with Gene Set Enrichment Analysis (GSEA), the signaling pathways affected by the hub genes were verified. Finally, we divided TB patients into two subgroups based on autophagy-related genes, and the immune microenvironment of patients in different subgroups was significantly different. Our study found two autophagy-related hub genes that could affect TB and divide TB samples into two subgroups. This finding is of great significance for TB treatment and provides new ideas for exploring the pathogenesis of M. tuberculosis.
Kajian Hukum Tanggung Jawab Perusahaan Transportasi Online terhadap Keselamatan Konsumen
Authors: Fachrurozy M , Sidi Redyanto , Zarzani T. Riza 
Published: September 2023

Dalam kasus pelanggaran hak konsumen, diperlukan kehati-hatian dalam menganalisis siapa yang harus bertanggung jawab dan seberapa jauh tanggung jawab dibebankan kepada pihak-pihak yang bersangkutan. Tanggung jawab pelaku usaha telah diatur dalam Undang-Undang Nomor 08 Tahun 1999 tentang perlindungan konsumen atau UUPK, Pasal 19 sampai dengan 28, yang meliputi prinsip tanggung jawab berdasarkan kesalahan (Liability Based On Fault Principle) dan prinsip tanggung jawab mutlak (absolute liability principle) Rumusan masalah dalam penelitian ini adalah: Bagaimana aturan hukum bagi pengguna transportasi?on line legislasi, Apa peran jalur transportasi pada penggunaan jalur transportasi, Apa tanggung jawab perusahaan transportasi kepada konsumen Gojek jika terjadi kecelakaan. Metode penelitian yang digunakan adalah penelitian kepustakaan (Library Research) dengan sumber berupa Buku, Undang-Undang, Peraturan Pemerintah, dan Penelitian Lapangan (Field Research). Perusahaan Go-jek yang bergerak dalam bisnis jasa transportasi yang menggunakan media internet tunduk pada peraturan di atas, dan melakukan setiap kewajiban dalam pemenuhan jaminan dan/atau garansi yang disepakati dalam perjanjian. Pasal 19 ayat (1) Undang-Undang Nomor 08 Tahun 1999 menjelaskan bahwa pelaku usaha bertanggung jawab memberikan ganti rugi atas kerusakan, pencemaran, dan/atau kerugian konsumen akibat konsumsi barang dan/atau jasa sejenis yang diproduksi atau diperdagangkan.
Implementasi Hak Pelayanan Kesehatan Pasien Tidak Mampu Berdasarkan Undang-Undang Nomor 44 Tahun 2009 Dalam Praktiknya di RSUD KH Daud Arif Kuala Tungkal
Authors: Taufan M , Ibrahim Ibrahim , Fatriansyah Fatriansyah 
Published: September 2023

Berdasarkan Pasal 28H ayat (1) Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 telah ditegaskan bahwa setiap orang berhak memperoleh pelayanan kesehatan, tentu saja apabila kita artikan bahwa setiap orang baik itu mereka yang mampu dalam segi ekonomi ataupun tidak mampu berhak mendapatkan pelayanan kesehatan. Tujuan penelitian ini adalah untuk memahami dan menganalisis implementasi pemberian hak pelayanan kesehatan pasien tidak mampu berdasarkan Undang-Undang Nomor 44 Tahun 2009 di RSUD KH Daud Arif Kuala Tungkal, dan untuk menganalisis kendala apa yang dihadapi dan upaya apa yang dilakukan dalam implementasi pelayanan kesehatan bagi masyarakat tidak mampu atau miskin berdasarkan Undang-Undang Nomor 44 Tahun 2009 di RSUD KH Daud Arif Kuala Tungkal. Metode penelitian bersifat deskriptif yang menggunakan tipe penelitian yuridis empiris. Hasil penelitian diperoleh yaitu bahwa Implementasi pelayanan Kesehatan bagi masyarakat miskin di RSUD KH Daud Arif Kuala Tungkal antara lain adalah; pelayanan administrasi, pelayanan medis, dan pelayanan obat-obatan telah dilaksanakan dengan cukup baik namun masih kurang maksimal. Kendala yang di temukan dalam pelaksanaan pelayanan Kesehatan bagi masyarakat miskin /kurang mampu di RSUD KH Daud Arif Kuala Tungkal antara lain adalah : ketidaktepatan sasaran jaminan kesehatan masyarakat berdasarkan kriteria miskin, pelayanan kesehatan yang masih kurang maksimal dan kurangnya informasi mengenai program bantuan pelayanan kesehatan terhadap masyarakat miskin. Upaya yang dilakukan dalam mengatasi kendala tersebut antara lain melakukan pembaharuan data masyarakat miskin/kurang mampu, pemenuhan sumber daya manusia kesehatan, dan melakukan sosialisasi ke masyarakat. Saran yang dapat penulis berikan Pemerintah Kabupaten Tanjab Barat harus melakukan evaluasi terhadap pelaksanaan program kesehatan untuk masyarakat miskin untuk mengetahui perkembangan program tersebut, melalui evaluasi program ini diharapkan pemerintah mengetahui apa yang dirasakan dan diharapkan masyarakat, selain itu pemerintah harus mendata dan melakukan verifikasi serta validasi secara langsung agar penerima program benar-benar warga miskin yang membutuhkan, dan perlu adanya revitalisasi agen sosialisasi program kepada masyarakat agar sumber informasi mengenai program dapat diterima oleh seluruh masyarakat miskin serta perlu memberikan beasiswa kepada tenaga medis sehingga dapat meningkatkan kompetensi dan tercapainya pelayanan kesehatan yang prima serta terpenuhinya sumber daya manusia kesehatan yang berkualitas
Identifikasi Faktor-Faktor Iklim Keselamatan Kerja terhadap Kinerja Keselamatan Kerja pada Proyek Konstruksi Di Provinsi Jambi
Authors: Kutni Darul , Carlo Nasfryzal , Utama Wayudi P 
Published: September 2023

Even though the construction sector provides business opportunities for workers, this sector also contributes 30% -40% of accidents and fatalities. For this reason, it is necessary to identify the factors of the work safety climate and their influence on work safety performance. This study aims to identify and measure the work safety factors and safety performance and which dominantly improves safety performance. The third aim to evaluate the relationship model between work safety climate and work safety performance. This research adopts 45 safety climate variables Zahoor, 2017 and uses 275 construction workers in Jambi Province. The data collection techniques with primary (informants) and secondary data (K3 documents and literature studies) utilize observation, direct interviews, and questionnaires. The results study found that the first three factors form the work safety factor (FIK1, FIK 2, FIK3). For named FIK1 to become Management Commitment and OSH resources, Procedures and Awareness of FIK2, FIK3 is named Perception of Accidents. In the second stage, the research found only factor 3 or IK3, namely the Perception of Accidents that affected safety performance. In the third stage, the study found that the safety performance measurement model only had the third factor, namely the Perception of Accidents, which could be used in a structural equation model that affected safety performance. Hopefully that understanding and knowing the observed variables from CI can help the project management team design the right strategy to create a safe project environment.
PENERAPAN ETIKA BISNIS DENGAN PRINSIP MAQASHID SYARIAH PADA USAHA MINUMAN
Authors: Haslinah Haslinah , Arafah Muh. , Desti Desti , Miar Miar 
Published: September 2023

AbstractThe trend of consuming contemporary drinks among today's youth has great potential to increase the amount of contemporary beverage consumption in Indonesia. With the mushrooming of drink outlets in various cities, it is proof that the audience is increasing. This study aims to find out how the application of business ethics with maqashid sharia principles to contemporary beverage businesses. This study uses a descriptive qualitative approach and is a type of field study research. Data collection techniques were carried out by observation and interviews with beverage business owners and employees. The results of the study found that the process and application of business ethics in producing drinks had been carried out well, but in the case of hifdzu al-aql in maintaining reason it had not been carried out properly, prospective employees should have been taught how to produce drinks from the initial stage to the end during the training. properly, as well as in terms of hifdzu an-nasl protecting offspring, we must not lose consumer confidence, especially in terms of good servants. As Muslim business people, in running their business, they should apply business ethics properly and according to the provisions in the Qur'an, hadith and other Islamic sources.Keywords: Business Ethics, Maqashid Sharia, Beverage Business, Production, Consumers Abstrak Tren mengkonsumsi minuman kekinian pada kalangan muda zaman sekarang sangat berpotensi besar guna meningkatkan jumlah konsumsi minuman kekinian di Indonesia. Dengan menjamurnya gerai minuman di berbagai kota menjadi bukti bahwa penikmatnya semakin meningkat. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan etika bisnis dengan prinsip maqashid syariah pada usaha minuman kekinian. Penelitian ini menggunakan pendekatan kualitatif deskriptif dan jenis penelitian studi lapangan, Teknik pengumpulan data dilakukan dengan observasi dan wawancara dengan pemilik dan karyawan usaha minuman. Hasil penelitian didapat bahwa proses dan penerapan etika bisnis dalam memproduksi minuman sudah dijalankan dengan baik, akan tetapi dalam hal hifdzu al-aql dalam menjaga akal belum terlaksana dengan baik, seharusnya pada saat pelatihan calon karyawan sudah diajarkan bagaimana cara memproduksi minuman mulai tahap awal hingga akhir dengan baik, serta dalam hal hifdzu an-nasl menjaga keturunan, kita tidak boleh menghilangkan kepercayaan konsumen terutama dalam hal pelayan yang baik. Sebagai pelaku bisnis muslim dalam menjalankan bisnisnya seharusnya menerapkan etika bisnis dengan baik dan sesuai ketetapan dalam Al-Qur’an, hadis dan sumber Islam lainnya.Kata kunci: Etika Bisnis, Maqashid Syariah, Usaha Minuman, Produksi, Konsumen
Extrusion-based 3D printing of osteoinductive scaffolds with a spongiosa-inspired structure
Authors: Kühl Julie , Gorb Stanislav , Kern Matthias , Klüter Tim , Kühl Sebastian , Seekamp Andreas , Fuchs Sabine 
Published: September 2023

Critical-sized bone defects resulting from trauma, inflammation, and tumor resections are individual in their size and shape. Implants for the treatment of such defects have to consider biomechanical and biomedical factors, as well as the individual conditions within the implantation site. In this context, 3D printing technologies offer new possibilities to design and produce patient-specific implants reflecting the outer shape and internal structure of the replaced bone tissue. The selection or modification of materials used in 3D printing enables the adaption of the implant, by enhancing the osteoinductive or biomechanical properties. In this study, scaffolds with bone spongiosa-inspired structure for extrusion-based 3D printing were generated. The computer aided design process resulted in an up scaled and simplified version of the bone spongiosa. To enhance the osteoinductive properties of the 3D printed construct, polycaprolactone (PCL) was combined with 20% (wt) calcium phosphate nano powder (CaP). The implants were designed in form of a ring structure and revealed an irregular and interconnected porous structure with a calculated porosity of 35.2% and a compression strength within the range of the natural cancellous bone. The implants were assessed in terms of biocompatibility and osteoinductivity using the osteosarcoma cell line MG63 and patient-derived mesenchymal stem cells in selected experiments. Cell growth and differentiation over 14 days were monitored using confocal laser scanning microscopy, scanning electron microscopy, deoxyribonucleic acid (DNA) quantification, gene expression analysis, and quantitative assessment of calcification. MG63 cells and human mesenchymal stem cells (hMSC) adhered to the printed implants and revealed a typical elongated morphology as indicated by microscopy. Using DNA quantification, no differences for PCL or PCL-CaP in the initial adhesion of MG63 cells were observed, while the PCL-based scaffolds favored cell proliferation in the early phases of culture up to 7 days. In contrast, on PCL-CaP, cell proliferation for MG63 cells was not evident, while data from PCR and the levels of calcification, or alkaline phosphatase activity, indicated osteogenic differentiation within the PCL-CaP constructs over time. For hMSC, the highest levels in the total calcium content were observed for the PCL-CaP constructs, thus underlining the osteoinductive properties.
Human bone marrow stromal cells: the impact of anticoagulants on stem cell properties
Authors: Ferencakova Michaela , Benova Andrea , Raska Ivan , Abaffy Pavel , Sindelka Radek , Dzubanova Martina , Pospisilova Eliska , Kolostova Katarina , Cajka Tomas , Paclik Ales , Zikan Vit , Tencerova Michaela 
Published: September 2023

Background: Bone marrow stromal cells (BMSCs) are the source of multipotent stem cells, which are important for regenerative medicine and diagnostic purposes. The isolation of human BMSCs from the bone marrow (BM) cavity using BM aspiration applies the method with collection into tubes containing anticoagulants. Interactions with anticoagulants may affect the characteristics and composition of isolated BMSCs in the culture. Thus, we investigated how anticoagulants in isolation procedures and cultivation affect BMSC molecular characteristics.Methods: BM donors (age: 48–85 years) were recruited from the hematology clinic. BM aspirates were obtained from the iliac crest and divided into tubes coated with ethylenediaminetetraacetic acid (EDTA) or heparin anticoagulants. Isolated BMSCs were analyzed by flow cytometry and RNA-seq analysis. Further cellular and molecular characterizations of BMSCs including CFU, proliferation and differentiation assays, cytometry, bioenergetic assays, metabolomics, immunostaining, and RT-qPCR were performed.Results: The paired samples of isolated BMSCs obtained from the same patient showed increased cellular yield in heparin vs. EDTA samples, accompanied by the increased number of CFU colonies. However, no significant changes in molecular characteristics were found between heparin- and EDTA-isolated BMSCs. On the other hand, RNA-seq analysis revealed an increased expression of genes involved in nucleotide metabolism and cellular metabolism in cultivated vs. non-cultivated BMSCs regardless of the anticoagulant, while genes involved in inflammation and chromatin remodeling were decreased in cultivated vs. non-cultivated BMSCs.Conclusion: The type of anticoagulant in BMSC isolation did not have a significant impact on molecular characteristics and cellular composition, while in vitro cultivation caused the major change in the transcriptomics of BMSCs, which is important for future protocols using BMSCs in regenerative medicine and clinics.
Quantitative composite testing model based on measurement uncertainty and its application for the detection of phthalate esters
Authors: Huang Lina , Hu Yi , Li Guanwei , Ouyang Caiding , Yi Lezhou , Wu Shanshan , Zhu Zhenhai , Ma Tongmei 
Published: September 2023

To improve the quantitative detection efficiency of chemical analysis and reduce the detection cost, the sample pass rate was estimated and mathematical statistics were used to calculate the optimal group size (Kopt) of the composite testing to save on the maximum workload. A quantitative composite testing model was developed based on chemical analysis measurement uncertainty. Using this model, the maximum allowable number of composited samples (Kmax) is first calculated using parameters of regulated limits (L), limit of quantification (LOQ), and method measured uncertainty (Urel) to ensure that the sensitivity of the composite testing can meet the limit requirements. Finally, the appropriate composite group size (Ka) can be obtained by creating a balance between Kopt, Kmax, and the practical information used for that particular test. Furthermore, based on a constructed model, a practical quantitative composite testing method of 3–10 samples was established for the routine detection of toy phthalates (PAEs). The experimental results showed that the quantitative limits of 7 PAEs were 9.1–41.8 mg/kg, the relative expansion uncertainties were 16.6%–23.2%, and the recovery rates were 91.0%–112.3%, with a relative deviation of less than 10%. All these meet international PAEs standards. Compared with the traditional individual and qualitative composite testing, this model will not decrease the detection sensitivity, but can save up to 17.9%–80.4% of the workload when it is employed in toy PAEs testing with the pass rate of 80%–99%. This quantitative composite testing method will be implemented in the coming revision of ISO 8124-6 toy PAEs standards.
Diagnostic workup of endocrine dysfunction in recurrent pregnancy loss: a cross-sectional study in Northeast China
Authors: Zhang Liyang , Du Yushu , Zhou Jingshuang , Li Jiapo , Shen Hongfei , Liu Yilin , Liu Chuanyang , Qiao Chong 
Published: September 2023

ObjectiveTo evaluate the prevalence of abnormal endocrine dysfunction for recurrent pregnancy loss (RPL) amongst patients with two versus three or more pregnancy losses.MethodsThis cross-sectional study retrospectively collected pre-pregnancy data of 537 women diagnosed with RPL in Shengjing Hospital of China Medical University from 2017 to 2022, including the baseline data of patients and the test results of endocrine factors. Several endocrine dysfunction included in this study were: thyroid dysfunction, obesity, hyperprolactinemia, polycystic ovary syndrome and blood glucose abnormality. Furthermore, vitamin D level were collected to study its relationship with endocrine dysfunction. Finally, we subdivided the patients according to the number of previous pregnancy loss and compared the prevalence of endocrine dysfunction between subgroups.ResultsAmong 537 RPL patients, 278 (51.8%) patients had abnormal endocrine test results. The highest incidence of endocrine dysfunction was thyroid dysfunction (24.39%, 131/537), followed by hyperprolactinemia (17.34%, 85/490), obesity (10.8%, 58/537), polycystic ovary syndrome (10.50%, 56/533), and abnormal blood glucose (5.29%, 27/510). Only 2.47%(13/527) of patients have vitamin D level that reach the standard. After subdividing the population according to the number of pregnancy loss, we did not find that the incidence of endocrine dysfunction (P=0.813), thyroid dysfunction (P=0.905), hyperprolactinemia (P=0.265), polycystic ovary syndrome (P=0.638), blood glucose abnormality (P=0.616) and vitamin D deficiency (P=0.908) were different among patients with two versus three or more pregnancy losses. However, obesity (P=0.003) was found more frequently observed in patients with more times of pregnancy loss.ConclusionThe prevalence of endocrine dysfunction in RPL population is high. There is no difference in the prevalence of endocrine dysfunction, except for obesity, among patients with two or more pregnancy losses, which may suggest investigations of endocrine dysfunction when patients have two pregnancy losses.