bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between perceptions of recurrence risk and depression state among first‐episode ischemic stroke patients in rural areas: The mediating role of coping style
Authors: Liu Xueting , Zhang Zhenxiang , Lin Beilei , Guo Yunfei , Mei Yongxia , Ping Zhiguang , Wang Wenna , Jiang Hu , Wang Shaoyang , Zhang Chunhui , Chen Suyan , Zhang Qiushi 
Published: April 2023

AbstractAimsTo investigate the relationship between stroke survivors' perceptions of recurrence risk, coping styles and depression state, and the role coping styles play in mediating that relationship.DesignA cross‐sectional descriptive study.MethodsFrom one hospital in Huaxian, China, 320 stroke survivors were randomly selected as a convenience sample. In this research, the Simplified Coping Style Questionnaire, the Patient Health Questionnaire‐9 and the Stroke Recurrence Risk Perception Scale were all used. Structural equation modelling and correlation analysis were used to analyse the data. This research followed the EQUATOR and STROBE checklists.ResultsThere were 278 valid survey responses. There were mild to severe depressive symptoms in 84.8% of stroke survivors. In stroke survivors, there was a significant negative relationship (p < 0.01) between the positive coping of perceptions of recurrence risk and their depression state. Recurrence risk perception's impact on depression state was partly mediated, according to mediation studies, by coping style, with the mediation effect accounting for 44.92% of the overall effect.ConclusionsThe connection between perceptions of recurrence risk and depression state was mediated by the coping mechanisms of stroke survivors. A lower degree of depression state among survivors was connected with positive coping to the beliefs of recurrence risk.
Convergence and stability of Galerkin finite element method for hyperbolic partial differential equation with piecewise continuous arguments
Authors: Chen Yongtang , Wang Qi 
Published: April 2023

AbstractIn this paper, the convergence and stability of Galerkin finite element method for a hyperbolic partial differential equations with piecewise continuous arguments are investigated. Firstly, the variation formulation is derived by applying Green's formula and Galerkin finite element method to spatial direction of the original equation. Next, semidiscrete and fully discrete schemes are obtained and the convergence is analyzed in ‐norm rigorously. Moreover, the stability analysis shows that the semidiscrete scheme can achieve unconditionally stability. The sufficient conditions of stability for fully discrete scheme are also obtained under which the analytic solution is asymptotically stable. Finally, some numerical experiments are provided to demonstrate our theoretical results.
Decannulation in congenital central hypoventilation syndrome
Authors: Ghelab Zina , Bokov Plamen , Teissier Natacha , Micaelli Delphine , Patout Maxime , Hayotte Aurélie , Dauger Stéphane , Delclaux Christophe , Dudoignon Benjamin 
Published: April 2023

AbstractRationalePatients with congenital central hypoventilation syndrome (CCHS) require long‐term ventilation to ensure gas exchange and to prevent deleterious consequences for neurocognitive development. Two ventilation modes may be used for these patients depending on their tolerance, one invasive by tracheostomy and the other noninvasive (NIV). For patients who have undergone a tracheostomy, transition to NIV is possible when they meet predefined criteria. Identifying the conditions favorable for weaning from a tracheostomy is critical for the success of the process.ObjectiveThe aim of the study was to share our experience of decannulation in a reference center; we hereby describe the modality of ventilation and its effect on nocturnal gas exchange before and after tracheostomy removal.MethodsRetrospective observational study at Robert Debré Hospital over the past 10 years. The modalities of decannulation and transcutaneous carbon dioxide recordings or polysomnographies before and after decannulation were collected.ResultsSixteen patients underwent decannulation following a specific procedure for transition from invasive to NIV. All decannulations were successful. The median age at decannulation was 12.6 [9.4; 14.1] years. Nocturnal gas exchange was not significantly different before and after decannulation, while expiratory positive airway pressure and inspiratory time increased significantly. An oronasal interface was chosen in two out of three patients. The median duration of hospital stay for decannulation was 4.0 [3.8; 6.0] days.ConclusionOur study underlines that decannulation and transition to NIV are achievable in CCHS children using a well‐defined procedure. Patient preparation is crucial to the success of the process.
The insecticidal activity and mechanism of tebuconazole onNilaparvata lugens(Stål)
Authors: Cai Yongfeng , Ren Zhijie , Li Chengyue , Cai Tingwei , Yu Chang , Zeng Qinghong , He Shun , Li Jianhong , Wan Hu 
Published: April 2023

AbstractBACKGROUNDPrevious studies have shown that fungicides have insecticidal activity that can potentially be used as an insecticide resistance management strategy in the brown planthopperNilaparvata lugens(Stål). However, the mechanism that induces mortality ofN. lugensremains elusive.RESULTSIn the present study, the insecticidal activities of 14 fungicides againstN. lugenswere determined, of which tebuconazole had the highest insecticidal activity compared with the other fungicides. Furthermore, tebuconazole significantly inhibited the expression of the chitin synthase geneNlCHS1; the chitinase genesNlCht1,NlCht5,NlCht7,NlCht9, andNlCht10; and theβ‐N‐acetylhexosaminidase genesNlHex3,NlHex4,NlHex5andNlHex6; it significantly suppressed the expression of ecdysteroid biosynthetic genes as well, includingSDR,CYP307A2,CYP307B1,CYP306A2,CYP302A1,CYP315A1andCYP314A1ofN. lugens. Additionally, tebuconazole affected the diversity, structure, composition, and function of the symbiotic fungi ofN. lugens, as well as the relative abundance of saprophytes and pathogens, suggesting that tebuconazole reshapes the diversity and function of symbiotic fungi ofN. lugens.CONCLUSIONOur findings illustrate the insecticidal mechanism of tebuconazole, possibly by inhibiting normal molting or disrupting microbial homeostasis inN. lugens, and provide an important rationale for developing novel insect management strategies to delay escalating insecticide resistance. © 2023 Society of Chemical Industry.
Population pharmacokinetics of tenofovir given as either tenofovir disoproxil fumarate or tenofovir alafenamide in an African population
Authors: Kawuma Aida N. , Wasmann Roeland E. , Sinxadi Phumla , Sokhela Simiso M. , Chandiwana Nomathemba , Venter Willem D. F. , Wiesner Lubbe , Maartens Gary , Denti Paolo 
Published: April 2023

AbstractTenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF) are prodrugs of the nucleotide analogue tenofovir, which acts intracellularly to inhibit HIV replication. Whereas TDF converts to tenofovir in plasma and may cause kidney and bone toxicity, TAF mostly converts to tenofovir intracellularly, so it can be administered at lower doses. TAF leads to lower tenofovir plasma concentrations and lower toxicity, but there are limited data on its use in Africa. We used data from 41 South African adults living with HIV from the ADVANCE trial and described, with a joint model, the population pharmacokinetics of tenofovir given as TAF or TDF. The TDF was modeled to appear in plasma as tenofovir with a simple first‐order process. Instead, two parallel pathways were used for a TAF dose: an estimated 32.4% quickly appeared as tenofovir into the systemic circulation with first‐order absorption, whereas the rest was sequestered intracellularly and released into the systemic circulation as tenofovir slowly. Once in plasma (from either TAF or TDF), tenofovir disposition followed two‐compartment kinetics and had a clearance of 44.7 L/h (40.2–49.5), for a typical 70‐kg individual. This semimechanistic model describes the population pharmacokinetics of tenofovir when dosed as either TDF or TAF in an African population living with HIV and can be used as a tool for exposure prediction in patients, and to simulate alternative regimes to inform further clinical trials.
Analysis of histidine‐tagged recombinant proteins from nickel and copper coated surfaces by direct electrospray ionization and desorption electrospray ionization mass spectrometry
Authors: Javanshad Roshan , Taylor Christopher James , Delavari Niusha , Barkman Todd J. , Stull Frederick , Venter Andre R. 
Published: April 2023

RationalePurification of recombinant proteins is a necessary step for functional or structural studies and other applications. Immobilized metal affinity chromatography is a common recombinant protein purification method. Mass spectrometry (MS) allows for confirmation of identity of expressed proteins and unambiguous detection of enzymatic substrates and reaction products. We demonstrate the detection of enzymes purified on immobilized metal affinity surfaces by direct or ambient ionization MS, and follow their enzymatic reactions by direct electrospray ionization (ESI) or desorption electrospray ionization (DESI).MethodsA protein standard, His‐Ubq, and two recombinant proteins, His‐SHAN and His‐CS, expressed in Escherichia coli were immobilized on two immobilized metal affinity systems, Cu–nitriloacetic acid (Cu‐NTA) and Ni‐NTA. The proteins were purified on surface, and released in the ESI spray solvent for direct infusion, when using the 96‐well plate form factor, or analyzed directly from immobilized metal affinity‐coated microscope slides by DESI‐MS. Enzyme activity was followed by incubating the substrates in wells or by depositing substrate on immobilized protein on coated slides for analysis.ResultsSmall proteins (His‐Ubq) and medium proteins (His‐SAHN) could readily be detected from 96‐well plates by direct infusion ESI, or from microscope slides by DESI‐MS after purification on surface from clarified E. coli cell lysate. Protein oxidation was observed for immobilized proteins on both Cu‐NTA and Ni‐NTA; however, this did not hamper the enzymatic reactions of these proteins. Both the nucleosidase reaction products for His‐SAHN and the methylation product of His‐CS (theobromine to caffeine) were detected.ConclusionsThe immobilization, purification, release and detection of His‐tagged recombinant proteins using immobilized metal affinity surfaces for direct infusion ESI‐MS or ambient DESI‐MS analyses were successfully demonstrated. Recombinant proteins were purified to allow identification directly out of clarified cell lysate. Biological activities of the recombinant proteins were preserved allowing the investigation of enzymatic activity via MS.
Distributed finite‐time optimization algorithms for multi‐agent systems under directed graphs
Authors: Zhu Wenbo , Sun Changyin , Wang Qingling 
Published: April 2023

AbstractExisting distributed finite‐time optimization algorithms for continuous‐time multi‐agent systems require either undirected graphs or weight balanced digraphs, and distributed finite‐time optimization problems for weight unbalanced digraphs are still great challenging. Thus, the distributed finite‐time optimization problems for continuous‐time multi‐agent systems with strongly convex local cost functions are investigated under directed graphs in this article. First, a distributed finite‐time gradient estimator is constructed by using non‐smooth analysis and algebraic graph theory, then distributed finite‐time optimization algorithms and piecewise distributed finite‐time optimization algorithms are proposed based on the designed gradient estimator. The new proposed distributed finite‐time optimization algorithms which only require strongly connected graphs relax the balanced requirement. Furthermore, the communication bandwidth of systems could be saved by deploying the proposed piecewise distributed finite‐time optimization algorithms since the information exchange in the optimization process is reduced. Finally, simulation examples are given to verify the effectiveness of proposed distributed optimization algorithms.
Control Lyapunov function method for robust stabilization of multistable affine nonlinear systems
Authors: Barroso Nelson F. , Ushirobira Rosane , Efimov Denis 
Published: April 2023

AbstractIn this paper, we study the problem of robust stabilization of affine nonlinear multistable systems in the presence of exogenous disturbances. The results are based on the theory of input‐to‐state stability (ISS) and integral input‐to‐state stability (iISS) for systems with multiple invariant sets. The notions of ISS and iISS control Lyapunov functions (CLFs) and the small control property are extended within the multistability framework. Such properties are also complemented by the concept of a weak iISS CLF and corresponding small control property. It is verified that the universal control formula can be applied to yield the ISS (iISS) property for the closed‐loop system. The efficiency of the extended CLF framework in the multistable sense is illustrated for a Duffing system and in application to a noise‐induced transition in a semiconductor‐gas‐discharge gap system.
Historical development and the present status of Japanese dams
Authors: Itsukushima Rei 
Published: April 2023

AbstractDams have contributed to population growth and technological innovation by reducing the risk of flooding and allowing humans to cultivate productive alluvial soils on river floodplains. However, in countries where many dams have already been constructed, many problems have been observed, such as river environment degradation, aging of the embankments, and inadequate dam performance. As the social and natural environment surrounding dams is becoming more complex and diverse, it is necessary to understand the current overall status of dams and the history of their construction such that we may consider how social capital and dams are related to human society and the natural environment. In this study, the relationship of basic information of dams and the social background in which the dams exist was examined for Japan, where dam construction began in earnest in the late 1800s and became a driving force for economic development. The situations surrounding dams are drastically changing, as maintenance and management costs increase due to the aging of dams and water demand varies due to changes in the industrial structure of a region. Simultaneously, there are instances where dams are expected to reduce damage, such as in the presence of more severe and frequent droughts and floods caused by climate change. It is therefore necessary to remove or restructure dams while considering numerous complex and diverse factors, such as the local social conditions, potential future changes, and environmental impact of rivers.
Highly Crystalline Prussian Blue for Kinetics Enhanced Potassium Storage
Authors: Shu Wenli , Huang Meng , Geng Lishan , Qiao Fan , Wang Xuanpeng 
Published: April 2023

AbstractPrussian blue analogs (PBAs) are promising cathode materials for potassium‐ion batteries (KIBs) owing to their large open framework structure. As the K+ migration rate and storage sites rely highly on the periodic lattice arrangement, it is rather important to guarantee the high crystallinity of PBAs. Herein, highly crystalline K2Fe[Fe(CN)6] (KFeHCF‐E) is synthesized by coprecipitation, adopting the ethylenediaminetetraacetic acid dipotassium salt as a chelating agent. As a result, an excellent rate capability and ultra‐long lifespan (5000 cycles at 100 mA g−1 with 61.3% capacity maintenance) are achieved when tested in KIBs. The highest K+ migration rate of 10−9 cm2 s−1 in the bulk phase is determined by the galvanostatic intermittent titration technique. Remarkably, the robust lattice structure and reversible solid‐phase K+ storage mechanism of KFeHCF‐E are proved by in situ XRD. This work offers a simple crystallinity optimization method for developing high‐performance PBAs cathode materials in advanced KIBs.
Detection of Anaplasma phagocytophilum in fetal and placental tissue of bovine abortions and perinatal mortalities
Authors: Van Loo Hans , Pascottini Osvaldo Bogado , Hooyberghs Jozef , De Bleecker Koen , Ribbens Stefaan , Opsomer Geert , Pardon Bart 
Published: April 2023

AbstractBackgroundAnaplasma phagocytophilum is a tick‐borne zoonotic bacterium that is the aetiologic pathogen of tick‐borne fever (TBF) in ruminants. In clinical bovine cases of TBF, abortion and stillbirth may be observed. However, in this regard, the pathophysiology of TBF has not yet been completely elucidated, and no clear guidelines to diagnose A. phagocytophilum‐related abortions and perinatal mortalities (APM) are available.MethodsThis exploratory study aimed to investigate the presence of A. phagocytophilum in bovine cases of APM and determine whether placental or fetal spleen tissue has the greatest sensitivity for A. phagocytophilum identification. The placenta and fetal spleen of 150 late‐term bovine APM cases were analysed using real‐time PCR to detect A. phagocytophilum.ResultsA total of 2.7% of sampled placentas were positive for A. phagocytophilum, while none of the fetal spleen samples was.LimitationsNo histopathology to detect associated lesions was performed. Consequently, no evidence of causality between the detection of A. phagocytophilum and APM events could be achieved.ConclusionThe detection of A. phagocytophilum suggests a potential role of this pathogen in bovine APM, and placental tissue seems to be the most suitable tissue for its identification.
Convergence in floodplain pond communities indicates different pathways to community assembly
Authors: Chanut P. C. M. , Burdon F. J. , Datry T. , Robinson C. T. 
Published: April 2023

AbstractDisturbance can strongly influence ecosystems, yet much remains unknown about the relative importance of key processes (selection, drift, and dispersal) in the recovery of ecological communities following disturbance. We combined field surveys with a field experiment to elucidate mechanisms governing the recovery of aquatic macroinvertebrates in habitats of an alluvial floodplain following flood disturbance. We monitored macroinvertebrates in 24 natural parafluvial habitats over 60 days after a major flood, as well as the colonization of 24 newly-built ponds by macroinvertebrates over 45 days in the same floodplain. We examined the sources of environmental variation and their relative effects on aquatic assemblages using a combination of null models and Mantel tests. We also used a joint species distribution model to investigate the importance of primary metacommunity structuring processes during recovery: selection, dispersal, and drift. Contrary to expectations, we found that beta diversity actually decreased among natural habitats over time after the flood or the creation of the ponds, instead of increasing. This result was despite environmental predictors showing contrasting patterns for explaining community variation over time in the natural habitats compared with the experimental ponds. Flood heterogeneity across the floodplain and spatial scale differences between the experimental ponds and the natural habitats seemingly constrained the balance between deterministic and stochastic processes driving the ecological convergence of assemblages over time. While environmental selection was the dominant structuring process in both groups, biotic interactions also had a prominent influence on community assembly. These findings have profound implications towards understanding metacommunity structuring in riverscapes that includes common linkages between disturbance heterogeneity, spatial scale properties, and community composition.
Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes
Authors: McNeilly Alison D. , Gallagher Jennifer R. , Evans Mark L. , de Galan Bastiaan E. , Pedersen-Bjergaard Ulrik , Thorens Bernard , Dinkova-Kostova Albena T. , Huang Jeffrey-T. , Ashford Michael L. J. , McCrimmon Rory J. ,   on behalf of the Hypo-RESOLVE Consortium
Published: April 2023

Abstract
Aims/hypothesis
Chronic hyperglycaemia and recurrent hypoglycaemia are independently associated with accelerated cognitive decline in type 1 diabetes. Recurrent hypoglycaemia in rodent models of chemically induced (streptozotocin [STZ]) diabetes leads to cognitive impairment in memory-related tasks associated with hippocampal oxidative damage. This study examined the hypothesis that post-hypoglycaemic hyperglycaemia in STZ-diabetes exacerbates hippocampal oxidative stress and explored potential contributory mechanisms.

Methods
The hyperinsulinaemic glucose clamp technique was used to induce equivalent hypoglycaemia and to control post-hypoglycaemic glucose levels in mice with and without STZ-diabetes and Nrf2−/− mice (lacking Nrf2 [also known as Nfe2l2]). Subsequently, quantitative proteomics based on stable isotope labelling by amino acids in cell culture and biochemical approaches were used to assess oxidative damage and explore contributory pathways.

Results
Evidence of hippocampal oxidative damage was most marked in mice with STZ-diabetes exposed to post-hypoglycaemic hyperglycaemia; these mice also showed induction of Nrf2 and the Nrf2 transcriptional targets Sod2 and Hmox-1. In this group, hypoglycaemia induced a significant upregulation of proteins involved in alternative fuel provision, reductive biosynthesis and degradation of damaged proteins, and a significant downregulation of proteins mediating the stress response. Key differences emerged between mice with and without STZ-diabetes following recovery from hypoglycaemia in proteins mediating the stress response and reductive biosynthesis.

Conclusions/interpretation
There is a disruption of the cellular response to a hypoglycaemic challenge in mice with STZ-induced diabetes that is not seen in wild-type non-diabetic animals. The chronic hyperglycaemia of diabetes and post-hypoglycaemic hyperglycaemia act synergistically to induce oxidative stress and damage in the hippocampus, possibly leading to irreversible damage/modification to proteins or synapses between cells. In conclusion, recurrent hypoglycaemia in sub-optimally controlled diabetes may contribute, at least in part, to accelerated cognitive decline through amplifying oxidative damage in key brain regions, such as the hippocampus.

Data availability
The datasets generated during and/or analysed during the current study are available in ProteomeXchange, accession no. 1-20220824-173727 (www.proteomexchange.org). Additional datasets generated during and/or analysed during the present study are available from the corresponding author upon reasonable request.

Graphical abstract