bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I’d like accessibility analysis to help us shape the future”: Transportation practitioners and accessibility measurement
Authors: Rowangould Dana , Levine Kaylyn , Alcorn Louis , Karner Alex 
Published: March 2023

Abstract
Transportation agencies are becoming increasingly interested in measuring accessibility, or the ease with which people can reach desired destinations. In part, the concept is attractive because it reflects the primary purpose of a transportation system—to connect people to the opportunities they value. Academic researchers have identified a wide range of accessibility measures that vary widely in terms of their interpretability, data requirements, parameters, multimodalism, and relevance to different areas of transportation planning and decision-making. At the same time, new data and tools that facilitate and improve accessibility measurement are proliferating. Despite the promise of access measures, the landscape is vast and changing, which can be difficult for practitioners to navigate. In fact, the use of accessibility in practice is relatively limited, with only a small share of U.S. transportation agencies using these measures. In this paper, we draw from 45 interviews with transportation professionals and a follow-up survey to determine how U.S. transportation practitioners currently use accessibility measures, barriers to accessibility measurement, and opportunities to use accessibility measures moving forward. Our results point to a wide range of technical capacities and accessibility applications across agencies, a suite of considerations that influence whether and how accessibility measures are used, a desire among many practitioners to increase their use of accessibility, and barriers to doing so. We close with reflections on opportunities to expand and improve the use of accessibility measurement in practice to strengthen transportation decision making.
Spontaneous middle cerebral artery dissection: A series of six cases and literature review
Authors: Nounaka Yohei , Murai Yasuo , Shirokane Kazutaka , Matano Fumihiro , Koketsu Kenta , Nakae Ryuta , Watanabe Akira , Mizunari Takayuki , Morita Akio 
Published: March 2023

Abstract
Middle cerebral artery (MCA) dissection is rare, and various clinical presentations, including hemorrhage, ischemia, or comorbidities, and the changes in imaging findings over time hinder treatment decisions. The European Stroke Organization guidelines exclude MCA dissection. Few cases have been reported with no review of the relevant literature. Therefore, we reviewed the relevant literature and our own experience with non-traumatic MCA dissection cases to determine appropriate treatment strategies. At our institution and affiliated institutions, we encountered six cases of MCA dissection—five with infarction and one with hemorrhage. Two patients underwent revascularization, and one underwent an aneurysmectomy. We reviewed English and Japanese articles in PubMed and Medical Journal Web and summarized the results based on the relationships among age, sex, location, presence of an aneurysm, presence of angiography, history, treatment, and mode of onset. The clinical course, changes in imaging, treatment strategies, and prognosis were discussed. Eighty cases were included in the review. Cerebral aneurysms were more common distal to the M2 area (p=0.00) and were correlated with hemorrhage (p<0.001). Most hemorrhagic cases with aneurysms were treated surgically, while ischemic cases were treated with antithrombotic agents, and both had a similar neurological prognosis. There were some cases of rebleeding after antithrombotic therapy, especially in older adults.
Surgical treatment is recommended in cases of hemorrhage and confirmed aneurysms, particularly for lesions distal to the M2 area. Patients with aneurysm-associated ischemia should be followed-up, and antithrombotic treatment should be considered with particular care in older adults.
Alterations in the hepatocyte epigenetic landscape in steatosis
Authors: Schulz Marcel H. , Gasparoni Nina , Nordström Karl , Gasparoni Gilles , Laggai Stephan , Yang Xinyi , Sinha Anupam , Ebert Peter , Falk-Paulsen Maren , Kinkley Sarah , Chung Ho-Ryun , Rosenstiel Philip , Hengstler Jan G. , Walter Jörn , Kessler Sonja M. , Kiemer Alexandra K. , Maji Ranjan Kumar , Czepukojc Beate , Scherer Michael , Tierling Sascha 
Published: March 2023

Abstract
Fatty liver disease or the buildup of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of fat and alcohol diet towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified 4 relevant protein-protein interaction network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover 4 additional CpG loci and validate that aging related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis.
In silico construction and evaluation of anti-EGFR ScFv and IFN-β fusion protein as a novel immunocytokine for the treatment of HER1 positive breast cancer
Authors: Khan Muhammad Islam , Hassan Muhammad , Sohail Aamir , Ahmad Nadeem , Khan Idrees , Khan Mohsin Ahmad , Khan Muhammad Tahir 
Published: March 2023

Abstract
Context Human epidermal growth factor receptor 1 (HER1) positive breast cancer is characterized by overexpression of the HER1 receptor protein on cancer cells leading to aggressive disease and treatment resistance. Computational design can efficiently create immunocytokine that specifically target cancer cell antigens and modulate the immune response, making them a promising treatment for HER1-positive breast cancer.
Methods The current work involves computational tools to design a novel immunocytokine, including the anti-epidermal growth factor single-chain variable fragment (ScFv) against HER1 receptor with a connection to the functional part of a cytokine INF-β. The amino acid sequences of ScFv region of antibody and IFN-β were retrieved from gene bank (accession no. AFF61391.1) and (ABS89222.1) respectively, and fused together to form a chimeric protein, called ScFv-IFN-β fusion protein. Physicochemical properties and solubility were analyzed using ProtParam and SOLpro, respectively. The ScFv-IFN-β fusion protein was modeled in 3D using alpha-fold and refined with GalaxyRefine and assessed using PROCHECK and RAMPAGE. Allergenicity and mRNA stability were predicted using the AlgPred and RNAfold servers, respectively. Docking and molecular dynamic simulations were performed using HDOCK and iMOD servers, respectively. Our computational analysis predicted that the ScFv-IFN-β fusion protein is anticipated to exhibit solubility, possess a sturdy 3D structure, maintain stable mRNA structure, and effectively bind to both HER1 and IFN receptors, thus making it a suitable candidate for breast cancer treatment. The current findings appear encouraging and hold promise for future experimental investigations.
Asymptomatic Obstructive Ventilatory Defect is common among Rheumatoid Arthritis Patients
Authors: Hassan Asmaa M , Ali Ibrahim Abdelrhim , Osman Asim A 
Published: March 2023

Abstract
Background
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting about 0.5–2% of the population worldwide. Extra-articular involvement in RA is a common condition and can occur in up to 40% of patients. Pulmonary involvement is a common extra-articular manifestation and may affect parenchyma, pleura, airway, and vasculature. It occurs in 20 to 67% of RA patients and it is responsible for about 10–20% of mortality in RA patients. So evaluation of the patients with rheumatoid arthritis for any deterioration in their lung functions is essential to treat appropriately, improve their mobility and quality of life.
Objectives
The study aimed to evaluate the effect of RA on the pulmonary function tests (PFTs) among Sudanese RA patients attending Rheumatology clinics in Omdurman Military hospital.
Methods
This is an analytical cross-sectional hospital -based study conducted among Sudanese RA patients. The study included 32 RA patients who were not known to have any respiratory illnesses or chronic diseases. An interview questionnaire with personal data and brief medical history was filled by the investigator. Height and weight were measured and BMI was calculated. Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and Peak Expiratory flow Rate (PEFR) were measure for each participant by digital spirometer. Matching from control group with similar age and height was performed and the results were compared with normal reference values for Sudanese subjects.. The tested data was analyzed using SPSS version 25, t-test was used to compare the statistical significant (P-value ≤ 0.05 was considered statistical significant).
Results
In this study, all the measured parameters of the PFTs in RA patients were lower than the published reference normal values for Sudanese subjects with significant P values. The mean of FEV1, FVC, FEV1/FVC ratio and PRFR in RA patients was found to be 1.8 ± ,3 L/min, 2,1 ± ,4 L/min, 87.1 ± 12,2% and 223.6 ± 86.2 L/min respectively in compared to 2,4 ± ,1 L/min, 2,7 ± ,1 L/min,90.81 ± 2.6% and 345.4 ± 86.2 L/min respectively in the control group (P Value 0.001, 0.001,0.05, and 0.001 respectively). There was no statistical significance correlation between PFT and duration of age, disease, and BMI. Obstructive ventilatory defect was seen in 78.1% (25) of patients. Restrictive ventilatory defect was seen in only 6.3% (2) of patients and 15.6% (5) showed normal pattern.
Conclusion
Pulmonary function abnormalities are common in asymptomatic rheumatoid patients which were found to be obstructive defect. Different pattern of pulmonary function abnormalities had a manifested in RA patients and the obstructive pattern represents the most common feature. Spirometry is indicated as a baseline assessment and for follow up of RA patient to enhance early detection and management of the pulmonary involvement.
Pharmacokinetics, Pharmacodynamics, and Safety of Ciprofol Injectable in Chinese Subjects with Normal or Impaired Renal Function
Authors: Tao Jun , Liu Shuaibing , Zhao Yingying , Qi Lei , Yan Pangke , Wu Nan , Liu Xiao , Wang Xu , Liu Dongwei , Zhang Xiaojian , Tian Xin 
Published: March 2023

Abstract
Purpose
The study was designed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD) and safety of ciprofol injection in healthy subjects and patients with mild and moderate renal impairment, to provide a reference for the dosage adjustment in these populations.
Methods
A total of 24 subjects were enrolled in this study. An initial loading dose of ciprofol was 0.4 mg/kg for 1 min, followed by maintenance infusion at a rate of 0.4 mg/kg/h for 30 min were administered to subjects. To evaluate the PK of ciprofol and its metabolite M4, plasma and urine samples were collected. PD was evaluated using a modified observer’s alertness/sedation scale (MOAA/S) in combination with bispectral index (BIS) monitoring. Safety assessments were conducted throughout the trial process.
Results
The area under the curve (AUC) and maximum concentration (Cmax) of ciprofol in plasma for patients with renal impairment were only slightly higher (0.9- to 1.2-fold) than those subjects in with normal renal function. For the metabolite M4, AUC values were 1.3- and 2.1-fold greater in patients with mild and moderate renal impairment, respectively, than healthy controls. However, increased exposure to M4 in participants with renal impairment may not be clinically significant, as this metabolite is pharmacologically inactive. There was no obvious effect of renal impairment on the PD parameters. The study found that ciprofol injection was well-tolerated, with all AEs reported being mild or moderate in severity.
Conclusion
No dosage adjustment of ciprofol is necessary for patients with mild-to-moderate renal impairment who receive the injection.
Clinical trial registration:
NCT04142970(October, 2019).
Recent postoperative radiotherapy for left-sided breast cancer does not increase mortality of heart disease in Asians or Pacific islanders: SEER database analysis
Authors: Jingu Keiichi , Umezawa Rei , Yamamoto Takaya , Takahashi Noriyoshi , Suzuki Yu , Kishida Keita , Omata So , Ogawa Hiroaki , Sato Yuta , Harada Hinako , Seki Yasuhiro 
Published: March 2023

Abstract
Background
Radiation-induced heart damage has recently attracted attention, and serious heart damage due to radiation has been reported in patients with breast cancer. The purpose of this study was to evaluate the impact of radiotherapy on mortality from heart disease in Asians or Pacific islanders with breast cancer using the Surveillance, Epidemiology, and End Results (SEER) database.
Methods
Asians or Pacific islanders with stage 0 or I (AJCC 6th ) breast cancer between 2000 and 2015 were analyzed. The impact of radiotherapy for mortality from heart disease after treatment was evaluated by comparing patients who received radiotherapy for left-sided breast cancer, patients who received radiotherapy for right-sided breast cancer and patients who did not receive radiotherapy
Results
In 25,684 Asians or Pacific islanders, the incidence of cardiac death was higher in patients who did not receive radiotherapy than in patients who received radiotherapy. Among patients who received external beam irradiation, the incidences of cardiac death were 2.00% for patients with left-sided breast cancer and 1.69% for patients with right-sided breast cancer, with no significant difference (chi-square test, p = 0.427). In the period from 2000 to 2008, there was no significant difference between the cumulative heart-related death rates in patients who received radiotherapy and in patients who did not receive radiotherapy (Tarone-Ware test, p = 0.406); however, in 2009–2015, the cumulative heart-related death rate in patients who did not receive radiotherapy was significantly higher than that in patients who received radiotherapy (log-rank test, p < 0.001).
Conclusions
Heart-related death after treatment for breast cancer is relatively rare in Asians or Pacific islanders. Since at least 2000, the cardiac impact of postoperative radiotherapy has not been significant.
Exercise from home improves physical performance：A study conducted specifically for COVID-19
Authors: Wang Hsin-Huan , Tsai Wei-Chi , Tu Jui-Hung , Wu Bo-Han , Chen Chia-Hsiang 
Published: March 2023

Abstract

Purpose
COVID-19 has rampaged the world. Nowaday, a lot of people in Taiwan still experiencing working from home, as well as exercising from home (EFH) to maintain their physical health. This study aimed to investigate the difference in training efficacy by joining online workout courses and coach supervision.
Methods
Twenty participants were recruited in this study. The subjects were randomly divided into coach supervision and online training groups. A pre-test was first conducted, followed by a post-test after 8 weeks of training intervention. The tests were to measure the participant’s muscle hypertrophy and sports performance, with the former including InBody body composition analysis, and the latter including the assessment of jumping ability, 20-metre sprint, bench press, and squat performances. The two-way mixed design measures ANOVA was applied for statistical measurement. If the correlation between the two factors was significant, the Bonferroni post hoc test will be applied to determine the main effects. (α = 0.05).
Results
There was no significant difference between the two training groups. However, substantial differences were observed between the jumping ability, bench press performance, and squat performance of the pre- and post-tests in both groups, with the participants generally performing better in the latter case. In terms of body composition and muscle circumference, no significant changes were found between both tests.
Conclusion
Participating online training courses at home is recommended when exercising outdoor is forbidden. Moreover, online training not only reduces the transmission of coronavirus, but also helps improve the immunity in a safe environment.
Image Super-Resolution Based on Gated Residual and Gated Convolution Networks
Authors: Zhang Xiaoang , Peng Yali , Wang Wenan , Liu Shigang 
Published: March 2023

Abstract
Single image super-resolution based on deep neural network has been a hot topic in recent years. In this paper, we propose a gated residual and gated convolution network (GRGCN) to deal with super-resolution reconstruction. Gated residual (GR) and gated convolution (GC) are the products of introducing attention mechanism (AM) into deep neural network. Specifically, GR enables the network to focus on more important residual channel information and GC allows the network to pay attention on more important feature extraction regions. Meanwhile, we propose multi-level residual connection, which includes long connection, secondary connection and short connection. Three different levels of residual connection correspond to three scales of feature extraction module, namely residual cluster, residual group and residual block. By fusing the feature information on different scales, the convolution layer can efficiently extract the feature information. Experiments on benchmark datasets demonstrate that our proposed GRGCN has better performance and visual effects than state-of-the-art methods.
DFT and IQA study of substituent effect on the structure, stability, and bonding properties of CX2 singlet and triplet carbenes
Authors: Emami-meibodi Zahrasadat , Tavakol Hossein , Eskandari Kiamars 
Published: March 2023

Abstract
During this study, 6 carbenes with various substitutions (hydrogen, deuterium, fluorine, chlorine, bromine, and methyl) and 24 carbenoids (Li, Na, Be, and Mg) were designed to obtain extensive and comprehensive information about their structures, stabilities, atomic specifications, and bonding properties using MP2/aug-cc-pVTZ level of theory. Moreover, the PBEPBE DFT method was used for IQA analyses. The calculated molecular parameters showed both electronegativity and size of the ligand are effective on the studied structures, and the electronegativity effect is more intense than the size. Atomic hybridizations results showed the p indexes of carbon in triplet carbenes are also smaller than those in singlet carbenes, but this difference in halogen-containing carbenes is smaller than the other carbenes. In population analyses, except for sodium-based carbenoids, all carbenoids have higher Eg values than the carbenes. By considering the α-elimination as a method of preparation of these carbenes, the order of carbenes’ stabilities was obtained as f>c>b>m>h, which is the same as the order of electronegativities of the connected ligands. IQA analyses was performed to evaluate the relative stability of carbenes. It was found that the classical interaction in C-F is attractive (negative) unlike the other mentioned bonds energy for carbenes. This electrostatic term in C-F is larger in the singlet state than the triplet state, which leads to the singlet state of CF2 being more stable and consequently more favorable than its triplet state.
Metal(loid) pollution of agricultural soils downstream of a lead-zinc mine in southwest China: comprehensive evaluation of risks to food production and human health
Authors: Zhang Peiyu , Wang Wenyong , Li Xinyang , Gao Ting , Liu Benle , Longhua Wu , Tan Changyin , Christie Peter 
Published: March 2023

Abstract
It is very important to quantify accurately the risks from potentially toxic metal(loid)s to soils, the environment and human health in agricultural areas impacted by metal mining activities. Here, a total of 2184 surface soil samples (0-20 cm depth), 211 soil profile samples (0-100 cm depth) and samples of 11 plant species were collected from five agricultural areas downstream of a typical lead-zinc mine. The concentrations of Cd, Cr, Cu, Ni, Pb and Zn and As were determined. Amethod based on soil-plant and human health risks was used to evaluate the contamination. The result shows that there was significant soil contamination with Cd, Pb, Zn, Cu and As which exceeded the Risk Screening Values (RSV) in surface soil samples. Metal(loid) concentrations decreased with increasing distance from the water source of the irrigation area. Metal(loid) contents decreased with increasing soil depth and the contents of Cd, Pb, Zn, Cu and As exceeded the RSV values in the soils from depths 0 to 100 cm. The result of the evaluation indicated that there was no pollution with Cr or Ni, but there was contamination with Cd, Pb, Zn, As and Cu. And Cd should be the priority control element followed by Pb and As, and Cu and Zn should also be strictly regulated elements in future pollution remediation and policy development in the region studied. It is necessary to strengthen the supervision of pollutant outputs from mining areas, especially in contaminated surface water run-off.
Impact of presarcopenic dysphagia on 1-year mortality after videofluoroscopic swallowing study in patients with cancer
Authors: Moriyama Toshiyuki , Hachisuka Akiko , Matushima Yasuyuki , Tokunaga Mizuki , Hori Ryoko , Tashima Hiroyuki , Onishi Atuto , Inoue Sumire , Ito Hideaki , Ochi Mituhiro , Saeki Satoru 
Published: March 2023

Abstract

Purpose
Sarcopenic dysphagia is dysphagia due to low skeletal muscle mass and leads to increased pharyngeal residues. Presarcopenia is typified by low muscle mass without decreased muscle strength and physical function, unlike sarcopenia, and can also develop into dysphagia due to low skeletal muscle mass. This retrospective study aimed to investigate the impact of presarcopenic dysphagia on one-year mortality in patients with cancer who underwent a videofluoroscopic swallowing study because of dysphagia.
Methods
An operational definition of presarcopenic dysphagia based on presarcopenia and pharyngeal residues was adopted. The psoas muscle mass index (cm2/height2 (m2)), calculated by the psoas muscle area at the L3 vertebra via abdominal computed tomography and related to height, was used to assess presarcopenia with cut-off levels of 4.62 for males and 2.66 for females. Pharyngeal residues were assessed using a videofluoroscopic swallowing study. Patients' medical charts were analyzed to investigate one-year mortality after a videofluoroscopic swallowing study.
Results
Out of 111 consecutive cancer patients, 53 (47.7%) were defined as having presarcopenic dysphagia. In a forward-stepwise Cox proportional regression analysis, presarcopenic dysphagia (HR 2.599; 95% CI 1.158–5.834) was significantly associated with one-year mortality after a videofluoroscopic swallowing study, even after adjusting for the factors of operation, Functional Oral Intake Scale at discharge, and modified Barthel Index scores at discharge.
Conclusion
Presarcopenic dysphagia, defined as computed tomography-based presarcopenia and pharyngeal residues observed during a videofluoroscopic swallowing study, is associated with increased one-year mortality in patients with cancer and dysphagia.