bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental influences on ophthalmic conditions: A scoping review
Authors: Heilenbach Noah , Hu Galen , Lamrani Ryan , Prasad Jaideep , Ogunsola Titilola , Iskander Mina , Elgin Cansu Yuksel , McGowan Richard , Vieira Dorice , Al‐Aswad Lama A. 
Published: June 2023

AbstractBackgroundEnvironmental factors have been implicated in various eye pathologies. The purpose of this review is to synthesise the published research on environmental effects on eye disease.MethodsFour databases were searched for terms relating to environmental exposures and ophthalmic disease. Titles and abstracts were screened followed by full‐text review. Data was extracted from 118 included studies. Quality assessment was conducted for each study.ResultsAir pollutants, including nitrogen dioxide, nitrites, sulphur dioxide, particulate matter, carbon monoxide, ozone and hydrocarbons are associated with ocular conditions ranging from corneal damage to various retinopathies, including central retinal artery occlusion. Certain chemicals and metals, such as cadmium, are associated with increased risk of age‐related macular degeneration. Climate factors, such as sun exposure, have been associated with the development of cataracts. Living in rural areas was associated with various age‐related eye diseases whereas people living in urban settings had higher risk for dry eye disease and uveitis.ConclusionEnvironmental exposures in every domain are associated with various ophthalmic conditions. These findings underscore the importance of continued research on the interplay between the environment and eye health.
Development and validation of a novel nomogram to predict the impact of the polymorphism of the ICAM‐1 gene on the prognosis of ischemic cardiomyopathy
Authors: Naman Tuersunjiang , Abuduhalike Refukaiti , Abudouwayiti Aihaidan , Sun Juan , Mahemuti Ailiman 
Published: June 2023

AbstractThe current study investigated the association between polymorphisms of the ICAM‐1 gene and prognosis of Ischemic cardiomyopathy (ICM), and developed a prognostic nomogram for ICM on the basis of ICAM‐1 gene variants. The current study included totally 252 patients with ICM. In addition, PCR‐RFLP (polymerase chain reaction‐restriction fragment length polymorphism) was used to genotype SNPs in the ICAM‐1 gene in the patients. Later, the nomogram model was built by combining clinical data and ICAM‐1 gene variants. This study used the least absolute shrinkage and selection operator (LASSO) regression model to optimize feature selection into an ICM prognostic model. Furthermore, multivariate Cox‐regression was applied to build the prognostic model, which included clinical and gene features chosen by the LASSO regression model. Following that, the receiver operating characteristic (ROC) curve, C‐index, calibration plot analyses and decision curve analysis (DCA) were carried out to evaluate the discrimination ability, consistency, and clinical utility of the prognostic model, and the bootstrap method was adopted for internal validation. predicting factors rs112872667, treating by PCI or CABG, ventricular arrhythmia, left ventricular end‐diastolic diameter (LVDD), use of β‐blockers, systolic blood pressure (SBP), heart rate (HR), and serum sodium were incorporated into the prognostic nomogram. The constructed nomogram performed well in discrimination ability, as observed by the time‐dependent C‐index. Furthermore, as shown by calibration curves, our nomogram's predicted probabilities were highly consistent with measured values. With threshold probabilities, DCA suggested that our nomogram could be useful in the clinic. mutation of rs112872667 have critical predictive value on the prognosis of ICM, ICM patients with the mutant genotype (CT or TT) have higher survival probability than those with the wild genotype (CC). Mutation of rs112872667 in ICAM‐1 gene have critical predictive value on the prognosis of ICM, ICM patients with the mutant genotype (CT or TT) have higher survival probability than those with the wild genotype (CC).
Influence of obesity on osseointegration of implants with different surface treatments: A preclinical study
Authors: Silva Bruno Luís Graciliano , Sánchez‐Puetate Julio Cesar , Pinotti Felipe Eduardo , Marcantonio Camila Chierici , Pedroso Gabriel Gimenez , Junior Elcio Marcantonio , Marcantonio Rosemary Adriana Chierici 
Published: June 2023

AbstractObjectiveThe aim of the present study was to evaluate the effect of obesity on the osseointegration of implants with hydrophobic and hydrophilic surfaces.Materials and MethodsSixty‐four male rats were distributed among four experimental groups: H‐HB (Healthy/Hydrophobic): healthy animals with hydrophobic implants; H‐HL (Healthy/Hydrophilic): healthy animals with hydrophilic implants; O‐HB (Obese/Hydrophobic): animals with induced obesity and hydrophobic implants; O‐HL (Obese/Hydrophilic): animals with induced obesity and hydrophilic implants. One hundred and twenty‐eight implants were installed in the tibiae of the animals bilaterally (64 on the left tibiae and 64 on the right one) after 75 days of a specific diet (standard or high‐fat diet) and euthanasia was performed in the experimental periods of 15 and 45 days after implant placement. Bone formation was assessed by biomechanical analysis (on the left tibiae of each animal), and microtomographic and histomorphometric analyses (on the right tibiae of each animal). Statistical analysis was performed using the Shapiro–Wilk test for normality and ANOVA followed by Tukey test to observe whether there was a significant difference between groups (p < 0.05); the t‐test was used to compare the animals' body weight.ResultsThe biomechanical analysis showed an increase in the removal torque value of animals after 45 days in comparison to after 15 days, with the exception of O‐HB groups. The microtomographic analysis demonstrated no significant differences in the mineralized bone tissue volume between the groups. In the histomorphometric analysis, the H‐HL/45 day group/period demonstrated higher bone‐implant contact, in comparison to H‐HL/15 days and the O‐HL/45 day group/period showed an increase in bone area between the implant threads, in comparison to O‐HL/15 days.ConclusionIn conclusion, obesity does not interfere with the osseointegration of hydrophobic and hydrophilic implants.
Neurotensin and energy balance
Authors: Gereau Graydon B. , Garrison Sy’Keria D. , McElligott Zoe A. 
Published: June 2023

AbstractThe neurotensin system spans across the central nervous system, to the enteric nervous system (gut), and the periphery to govern behaviors and physiological responses that tune energy balance to maintain homeostasis. Neurotensin transmission is not only modulated by metabolic signals, neurotensin transmission itself can also impact metabolic state by exerting control over consumption, physical activity, and satiety signals. Many responses to sensory experiences and sleep processes are dictated by neurotensinergic activity via mechanisms that allow the organism to balance energy seeking and utilization to thrive in its environment. Given the broad reach neurotensin signaling has across the homeostatic landscape, understanding this system as a whole and examining new ways to target this system for therapeutic efficacy across many different conditions is necessary.image
Maternal cortisol levels in third trimester and early language development: A study of 1093 mother–child pairs from the Odense Child Cohort
Authors: Mumm Hanne , Dreyer Anja Fenger , Bleses Dorthe , Glintborg Dorte , Jensen Tina Kold , Boye Henriette , Trecca Fabio , Andersen Marianne Skovsager 
Published: June 2023

AbstractLanguage development during early childhood is considered an important marker of fetal neurodevelopment. Prenatal cortisol exposure plays a critical role in maturation of the fetal brain; however, the effect on offspring language development needs further investigation. In this prospective observational study we aimed to evaluate the association between maternal third trimester cortisol and early longitudinal offspring language development in the Odense Child Cohort (OCC) and to test whether there were sex differences in the association. The study cohort included 1093 mother–child dyads (570 boys and 523 girls). Fasting morning serum (s‐) cortisol was collected from third trimester (gestational week 26–28) pregnant women and measured by liquid chromatography–tandem mass spectrometry. Offspring receptive and productive vocabulary assessments by MacArthur‐Bates Communicative Development Inventories parent reports were completed every third month from children age 12–37 months. Levels of cortisol were higher in women carrying a girl (858 ± 214 nmol/L) than in women carrying a boy (820 ± 222 nmol/L). Higher third trimester maternal cortisol levels showed a positive association with development of productive vocabulary in boys at age 12–21 months (OR = 1.23, SE = 0.07, p = .005) and age 22–37 months (OR = 1.09, SE = 0.06, p = .967). Higher maternal cortisol levels in the third trimester were positively associated with receptive vocabulary in girls at 12–21 months of age (OR = 1.16, SE = 0.05, p = .002). Maternal third trimester s‐cortisol levels were positively associated with early language development in children at age 12–37 months.
Comparison between ultrasound and magnetic resonance imaging of the temporomandibular joint in juvenile idiopathic arthritis: A systematic review
Authors: Rotolo Rossana Patricia , d'Apuzzo Fabrizia , Femiano Felice , Nucci Ludovica , Minervini Giuseppe , Grassia Vincenzo 
Published: June 2023

AbstractObjectivesThe objectives of this systematic review were to evaluate the correlation between Ultrasound (US) and Magnetic Resonance Imaging (MRI) in patients with JIA and to investigate the association with Temporomandibular Disorders (TMD).Materials and MethodsThe protocol was registered in PROSPERO (CRD42022312734). Databases Medline, Embase, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, Latin American and Caribbean Health Sciences Literature were searched. Eligibility criteria were patients with JIA subjected to diagnostic evaluation using US and MRI. No language restrictions were applied. After duplicate study selection, data extraction and risk of bias assessment according to Cochrane were conducted. Data extraction of patients was conducted by two independent authors.ResultsFive observational studies were included with 217 participants (153 females and 64 males; mean age 11.3 years). The quality of the studies was overall satisfactory. The correlation between US and MRI in children with JIA was ‘moderate’ in acute arthritis while the chronic arthritis correlated positively in two studies.ConclusionsEven if MRI remains the more accurate imaging modality for the detection of TMJ of patients with JIA, US may be useful to early detect pathological conditions and to address the patient with JIA and putative TMJ involvement to a more accurate diagnosis with MRI and consequent appropriate treatment management.Clinical RelevanceMRI should be deemed necessary only secondary to less‐invasive assessments with US just to confirm the diagnosis or to increase sensitivity, accuracy of positive predictive values detected.
Exogenous application of a Burkholderia sp. and jasmonic acid at the postharvest stage for management of anthracnose in dessert banana (Musa acuminata)
Authors: Kumara U. M. Aruna , Costa Devika M. De 
Published: June 2023

AbstractThe present study was conducted to determine the potential of controlling natural (latent) and wound infections of anthracnose using a biological control agent (Burkholderia sp. [BS]) and jasmonic acid (JA). Exogenous application of BS (1 × 108 cfu/mL) and JA (0.2 mM) reduced both types of anthracnose in banana cultivars Kolikuttu and Seenikesel within a range of 67.6%–100%. Due to BS and JA treatments, three selected defence genes (β‐1,3‐glucanase, PR‐1 and chitinase) were up‐regulated in the fruit peels of the two banana cultivars over a period of 144 h after treatment (HAT), indicating the ability to induce host plant resistance by the two treatments. BS treatment resulted in a 1.5‐ to 2.5‐fold increase of the above gene transcripts under natural infection in both cultivars. The findings revealed that induction of the three selected defence genes varies depending on the type of the treatment and infection. JA‐treated fruits with natural infections showed a 1‐day delay of ripening and resulted in the lowest ripening indices till 6th day after treatment in comparison to the BS‐ and untreated banana. BS and JA concentrations used in the study, significantly reduced mycelial growth and spore production of C. musae. Lowering of the ripening index, reduction of mycelial growth and spore production of the fungal pathogen and increased expression of the three selected defence genes by BS and JA treatments reduced the disease progression and lesion development of anthracnose in the two banana cultivars under natural and wound infections of C. musae.
Exploring factors associated with parent‐reported early childhood caries with Alaska's childhood understanding behaviors survey data
Authors: Grage Laura , Wise Frances , Meyer Jennifer 
Published: June 2023

AbstractObjectivesEarly Childhood Caries (ECC) can negatively impact the lives of young children, despite being preventable. The purpose of this study was to utilize available data in Alaska to describe changes in parent reports of ECC, and identify factors related to ECC.MethodsThe Childhood Understanding Behaviors Survey (CUBS) is a population‐based survey of parents of 3‐year‐old children and was utilized to describe changes in: parent‐reported ECC among children with a dental visit, access to and or utilization of dental care, and consumption of three or more cups of sweetened beverages between 2009–2011 and 2016–2019. Logistic regression modeling was used to explore factors associated with parent‐reported ECC among children with a dental visit.ResultsOver time, a significantly smaller proportions of parents whose 3‐year‐old child had seen a dental professional reported ECC. Additionally, a smaller proportion of parents reported three or more cups of sweetened beverage consumption by their child, while larger proportions had seen a dental professional by age 3. Factors associated with parent‐reported ECC included consumption of three or more cups of sweetened beverages, and enrollment in Medicaid or Tribal health care insurance, while protective factors included a parent earning a college degree, and military insurance.ConclusionsAlthough at the statewide level, improvements were observed in parent‐reported measures over time, regional disparities were apparent. Social and economic factors as well as excessive consumption of sweetened beverages appear to play important roles in ECC. CUBS data can help identify trends in ECC within Alaska.
Sex chromosome heteromorphism and the Fast‐X effect in poeciliids
Authors: Darolti Iulia , Fong Lydia J. M. , Sandkam Benjamin A. , Metzger David C. H. , Mank Judith E. 
Published: June 2023

AbstractFast‐X evolution has been observed in a range of heteromorphic sex chromosomes. However, it remains unclear how early in the process of sex chromosome differentiation the Fast‐X effect becomes detectible. Recently, we uncovered an extreme variation in sex chromosome heteromorphism across poeciliid fish species. The common guppy, Poecilia reticulata, Endler's guppy, P. wingei, swamp guppy, P. picta and para guppy, P. parae, appear to share the same XY system and exhibit a remarkable range of heteromorphism. Species outside this group lack this sex chromosome system. We combined analyses of sequence divergence and polymorphism data across poeciliids to investigate X chromosome evolution as a function of hemizygosity and reveal the causes for Fast‐X effects. Consistent with the extent of Y degeneration in each species, we detect higher rates of divergence on the X relative to autosomes, a signal of Fast‐X evolution, in P. picta and P. parae, species with high levels of X hemizygosity in males. In P. reticulata, which exhibits largely homomorphic sex chromosomes and little evidence of hemizygosity, we observe no change in the rate of evolution of X‐linked relative to autosomal genes. In P. wingei, the species with intermediate sex chromosome differentiation, we see an increase in the rate of nonsynonymous substitutions on the older stratum of divergence only. We also use our comparative approach to test for the time of origin of the sex chromosomes in this clade. Taken together, our study reveals an important role of hemizygosity in Fast‐X evolution.
Scaffold protein RACK1 regulates BR signaling by modulating the nuclear localization of BZR1
Authors: Li Zhiyong , Fu Yajuan , Wang Yuzhu , Liang Jiansheng 
Published: June 2023

Summary

Brassinosteroids (BRs) are a group of plant‐specific steroid hormones, which induces the rapid nuclear localization of the positive transcriptional factors BRASSINAZOLE RESISTANT1/2 (BZR1/2). However, the mechanisms underlying the regulation of nucleocytoplasmic shuttling of BZR1 remain to be fully elucidated.

In this study, we show that the scaffold protein Receptor for Activated C Kinase 1 (RACK1) from Arabidopsis is involved in BR signaling cascades through mediating the nuclear localization of BZR1, which is tightly retained in the cytosol by the conserved scaffold protein 14‐3‐3s.

RACK1 can interact with BZR1 and competitively decrease the 14‐3‐3 interaction with BZR1 in cytosol, which efficiently enhances the nuclear localization of BZR1. 14‐3‐3 also retains RACK1 in cytosol through their interaction. Conversely, BR treatment enhances the nuclear localization of BZR1 by disrupting the 14‐3‐3 interaction with RACK1 and BZR1.

Our study uncovers a new mechanism that integrates two kinds of conserved scaffold proteins (RACK1 and 14‐3‐3) coordinating BR signaling event.
Attachment representations in 7‐year‐old children at familial high risk of schizophrenia or bipolar disorder: Associations with mental disorders and daily functioning
Authors: Gregersen Maja , Ellersgaard Ditte , Søndergaard Anne , Christiani Camilla , Hemager Nicoline , Spang Katrine Søborg , Burton Birgitte Klee , Uddin Md Jamal , Ohland Jessica , Gantriis Ditte , Greve Aja , Hjorthøj Carsten , Mors Ole , Plessen Kerstin Jessica , Nordentoft Merete , Clemmensen Lars , Jepsen Jens Richardt Møllegaard , Thorup Anne Amalie Elgaard 
Published: June 2023

BackgroundAttachment quality may affect psychological functioning. However, evidence on attachment representations and their correlates in children born to parents with schizophrenia and bipolar disorder is sparse.MethodsWe compared attachment representations in a Danish sample of 482 children aged 7 years at familial high risk of schizophrenia, bipolar disorder, and population‐based controls and examined associations between attachment and mental disorders and daily functioning. Attachment representations were examined with the Story Stem Assessment Profile (SSAP). Mental disorders were ascertained in diagnostic interviews. Daily functioning was assessed with the Children's Global Assessment Scale.ResultsWe found no between‐group differences in attachment. Higher levels of secure attachment were associated with decreased risk of concurrent mental disorders in the schizophrenia high‐risk group. Higher levels of insecure and disorganized attachment were associated with increased risk of mental disorders across the cohort. Higher levels of secure and insecure attachment were associated with better and poorer daily functioning, respectively. In the current study, results regarding defensive avoidance could not be reported due to methodological limitations.ConclusionFamilial high risk of schizophrenia (FHR‐SZ) or bipolar disorder is not associated with less secure or more insecure attachment at age 7. Insecure and disorganized attachment representations index risk of mental disorders and poorer functioning. Secure attachment may be a protective factor against mental disorders in children at FHR‐SZ. Validation of the SSAP is needed.
Determining soil quality indicators for alluvial plains in the semi‐arid tropics
Authors: Lalitha M. , Kalaiselvi B. , Dharumarajan S. , Anil Kumar K. S. , Ramesh Kumar S. C. , Srinivasan R. , Ramamurthy V. , Hegde Rajendra 
Published: June 2023

AbstractEvaluating soil quality in the alluvial plains of the semi‐arid tropics is vital to understand the impact of existing land management practices, thus facilitating the adoption of more sustainable agricultural methods. We analysed soil profiles using 146 horizon‐specific samples from 24 pedons, representing seven soil series from the sub‐tropical to semi‐arid River Cauvery Delta basin, Tamil Nadu, India. Using principal component analysis (PCA), we identified minimum datasets (MDS) from 30 different soil properties. The plough layer's MDS were clay content, exchangeable sodium percentage (ESP), very coarse sand content, soil pH and soil organic carbon (SOC). For the subsurface layer, sand content, ESP, SOC, diethylene‐triamine‐pentaacetic acid extractable zinc (DTPA‐Zn), and very coarse sand content were identified as the MDS. Soil quality index (SQI) values were 0.47–0.72 for the plough layer and 0.46–0.56 for the subsurface soil, suggesting limited soil function support in subsurface soils. Surface soil‐site suitability criteria displayed a moderate correlation with SQI values derived via PCA, with additive (R2 = .545) and weighted additive indices (R2 = .659). Both simple additive index and weighted derived SQIs demonstrated a moderate association with rice yield (R2 = .50 and .55, respectively). This research indicates the potential to identify soil quality indicators in alluvial plains of semi‐arid tropics.
Exploring the spatiotemporal relationships between search flows and travel flows
Authors: Chen Yuzhou , Gong Zhaoya , Ma Qiwei , Tao Ran 
Published: June 2023

AbstractNumerous studies attempted to associate search engine data with travel behaviors. However, most existing studies focus on the destinations of search and travel, while ignoring the origins, which embed critical information of where the search requests were initiated and where the travelers came from. In this study, we explore the relationships between two types of intercity origin–destination flow data, namely travel flows and search flows, which, respectively, record the number of travelers and search requests from one city towards another. By comparing the two flows during holiday and non‐holiday, we examine their complex spatiotemporal relationships from multiple perspectives, including time‐lag effect, distance decay effect, spatial autocorrelation, network community, cities' rankings, and important factors of search and travel activities. The findings can deepen our understanding of search and travel behaviors, hence they can help decision makers to develop targeted strategies to enhance city's attractiveness, improve transportation infrastructure, and promote tourism.