bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of metabolic syndrome on postoperative complications and long-term survival of patients with colorectal cancer
Authors: Zhu Ce , Mao Chenchen , Cai Wentao , Zheng Jingwei , Yang Hui , You Tao , Chen Jian , Yu Yaojun , Shen Xian , Li Liyi 
Published: June 2023

BackgroundMetabolic syndrome (MetS) is associated with poor prognosis in many cancers. However, the relationship between metabolic syndrome and overall survival (OS) in patients with colorectal cancer (CRC) remains unclear. We aimed to comprehensively analyze whether MetS could affect postoperative complications and long-term survival in patients with CRC.MethodsWe included patients who underwent CRC resection at our center between January 2016 and December 2018. Bias was reduced through propensity score matching analysis. Patients with CRC were divided into the MetS and non-MetS groups based on whether they had MetS. Univariate and multivariate analyses were used to identify risk factors affecting OS.ResultsWe included 268 patients; among them, 120 were included for further analysis after propensity score matching. There were no significant between-group differences in the clinicopathological features after matching. Compared with the non-MetS group, the MetS group had a shorter OS (P = 0.027); however, there was no significant between-group difference in postoperative complications. Multivariate analysis revealed that MetS (hazard ratio [HR] = 1.997, P = 0.042), tumor-node-metastasis stage (HR = 2.422, P = 0.003), and intestinal obstruction (HR = 2.761, P = 0.010) were independent risk factors for OS.ConclusionsMetS affects the long-term survival of patients with CRC without affecting postoperative complications.
Intraoral scanners in children: evaluation of the patient perception, reliability and reproducibility, and chairside time—A systematic review
Authors: Serrano-Velasco Diego , Martín-Vacas Andrea , Paz-Cortés Marta M. , Giovannini Giovanni , Cintora-López Patricia , Aragoneses Juan Manuel 
Published: June 2023

PurposeThe aim of this systematic review is to evaluate the perception of the patient, the chairside time, and the reliability and/or reproducibility of intraoral scanners for full arch in pediatric patients.MethodsA data search was performed in four databases (Medline-Pubmed, Scopus, ProQuest and Web of Science) in accordance with the PRISMA 2020 statements. Studies were classified in three categories (patient perception, scanning or impression time and reliability and/or reproducibility). The resources, the data extraction and the quality assessment were carried out independently by two operators. The variables recorded were population characteristics, material and methods aspects and included country, study design and main conclusion. A quality assessment of the selected studies was performed with QUADAS-2 tool, and Kappa-Cohen Index was calculated to analyze examiner agreement.ResultsThe initial search obtained 681 publications, and finally four studies matching inclusion criteria were selected. The distribution of the studies in the categories was three for the analysis of the patient's perception and scanning or impression time; and two items to assess the reliability and/or reproducibility of intraoral scans. All included studies have a repeated measures–transversal design. The sample size ranged between 26 and 59 children with a mean age. The intraoral scanners evaluated were Lava C.O.S, Cerec Omnicam, TRIOS Classic, TRIOS 3-Cart and TRIOS Ortho. The quality assessment of the studies using QUADAS-2 tool revealed a low risk of bias while evaluating patient perception, but an unclear risk of bias in the analysis of accuracy or chairside time. In relation to the applicability concerns, the patient selection was of high risk of bias. All studies agreed that the patient perception and comfort is better with intraoral scanners in comparison with the conventional method. The accuracy or reliability of the digital procedure is not clear, being clinically acceptable. In relation with the chairside time, it depends on the intraoral scanner, with contradictory data in the different analyzed studies.ConclusionThe use of intraoral scanners in children is a favorable option, finding a significantly higher patient perception and comfort with intraoral scanners compared to the conventional impression method. The evidence for reliability or reproducibility is not strong to date, however, the differences between the intraoral measurements and the digital models would be clinically acceptable.
Determination of α1-acid glycoprotein (AGP) concentration by HPLC in patients following local infiltration analgesia for primary total hip arthroplasty and its relation to ropivacaine (total and unbound)
Authors: Abbas Muhammad , Alossaimi Manal A. , Altamimi Abdulmalik S. A. , Alajaji Mai , Watson David G. , Shah Sayyed I. , Shah Yasar , Anwar Mohammad S. 
Published: June 2023

Introduction: This study was performed to determine the levels of α1-acid glycoprotein (AGP) in old-age patients undergoing total hip arthroplasty. AGP is considered an acute phase protein produced during the acute phase reaction in the body to various stimuli; their proper monitoring is thus important.Methods: In order to study how AGP concentrations in old age patients change in response to surgical stress (total hip arthroplasty), a high-performance liquid chromatography assay was performed to measure AGP levels. AGP was isolated from the plasma by adding perchloric acid and was analyzed using PLRP-S 4000°A column. The mobile phase consisted of 1 mL TFA/L of water (Solvent A pH 2) and 1 mL TFA/L of acetonitrile (Solvent B). The gradient used was as follows: 0 min 18% B and 82% A, 15 min 60% B and 40% A, and 17 min 60% B and 40% A followed by column re-equilibration for 7 min before the next injection. AGP peak was obtained between 8.8 and 8.9 min. The method was fully optimised according to established guidelines.Results: The data obtained were analyzed on ChromQuest software. AGP concentrations were determined in all samples, including baseline and samples taken at different timed intervals. The peak for AGP was obtained between 8.8 and 8.9 min for both standard AGP and patient plasma. The graphs indicate that AGP concentration in almost all patient samples increased considerably, especially after 4 h and 24 h—for example, initial concentration in patient 1 was 10.36 mg/100 mL but, after 24 h, increased to 23.50 mg/100 mL. There was thus almost a 13 mg/100 mL increase in 24 h, which is confirmed by AGP concentration increasing after various conditions, including surgery. The increased plasma protein binding was comparatively associated with the unchanged free fraction of the drug.Conclusion: This surgically induced increase in AGP concentration resulted in increased plasma protein binding of the drug (ropivacaine), which in turn kept the free portion of ropivacaine stable during the postoperative period.
Prolonged voluntary wheel running reveals unique adaptations in mdx mice treated with microdystrophin constructs ± the nNOS-binding site
Authors: Hamm S. E. , Yuan C. , McQueen L. F. , Wallace M. A. , Zhang H. , Arora A. , Garafalo A. M. , McMillan R. P. , Lawlor M. W. , Prom M. J. , Ott E. M. , Yan J. , Addington A. K. , Morris C. A. , Gonzalez J. P. , Grange R. W. 
Published: June 2023

We tested the effects of prolonged voluntary wheel running on the muscle function of mdx mice treated with one of two different microdystrophin constructs. At 7 weeks of age mdx mice were injected with a single dose of AAV9-CK8-microdystrophin with (gene therapy 1, GT1) or without (gene therapy 2, GT2) the nNOS-binding domain and were assigned to one of four gene therapy treated groups: mdxRGT1 (run, GT1), mdxGT1 (no run, GT1), or mdxRGT2 (run,GT2), mdxGT2 (no run, GT2). There were two mdx untreated groups injected with excipient: mdxR (run, no gene therapy) and mdx (no run, no gene therapy). A third no treatment group, Wildtype (WT) received no injection and did not run. mdxRGT1, mdxRGT2 and mdxR performed voluntary wheel running for 52 weeks; WT and remaining mdx groups were cage active. Robust expression of microdystrophin occurred in diaphragm, quadriceps, and heart muscles of all treated mice. Dystrophic muscle pathology was high in diaphragms of non-treated mdx and mdxR mice and improved in all treated groups. Endurance capacity was rescued by both voluntary wheel running and gene therapy alone, but their combination was most beneficial. All treated groups increased in vivo plantarflexor torque over both mdx and mdxR mice. mdx and mdxR mice displayed ∼3-fold lower diaphragm force and power compared to WT values. Treated groups demonstrated partial improvements in diaphragm force and power, with mdxRGT2 mice experiencing the greatest improvement at ∼60% of WT values. Evaluation of oxidative red quadriceps fibers revealed the greatest improvements in mitochondrial respiration in mdxRGT1 mice, reaching WT levels. Interestingly, mdxGT2 mice displayed diaphragm mitochondrial respiration values similar to WT but mdxRGT2 animals showed relative decreases compared to the no run group. Collectively, these data demonstrate that either microdystrophin construct combined with voluntary wheel running increased in vivo maximal muscle strength, power, and endurance. However, these data also highlighted important differences between the two microdystrophin constructs. GT1, with the nNOS-binding site, improved more markers of exercise-driven adaptations in metabolic enzyme activity of limb muscles, while GT2, without the nNOS-binding site, demonstrated greater protection of diaphragm strength after chronic voluntary endurance exercise but decreased mitochondrial respiration in the context of running.
Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis
Authors: Luo Qiao , Zhang Jie-Xin , Huang Shuo , Hu Yong-He , Wang Han , Chen Xin 
Published: June 2023

PurposeTo conduct a systematic review and meta-analysis of observational studies of brain MRI, this paper assesses the effects of long-term exposure to high-altitude on brain structures in healthy people.MethodsObservational studies related to high-altitude, brain and MRI were systematically searched based on data retrieved from PubMed, Embase and Cochrane Library. The timescale for collecting literature was from the establishment of the databases to 2023. NoteExpress 3.2 was used to manage the literature. Two investigators performed literature screening and data extraction based on inclusion criteria, exclusion criteria, and literature quality. The quality of the literature was assessed using the NOS Scale. Finally, meta-analysis of included studies was performed using Reviewer Manager 5.3.ResultsInitially, 3,626 articles were retrieved. After screening, 16 articles (n = 756 participants) were included in the systematic review, and meta-analysis was performed on 6 articles (n = 350 participants). The overall quality of the included articles was at medium level, with a mean NOS score of 5.62. The results of meta-analysis showed that the differences between the HA group and LA group were not statistically significant, in total GM volume (MD: −0.60, 95% CI: −16.78 to 15.58, P = 0.94), WM volume (MD: 3.05, 95% CI: −15.72 to 21.81, P = 0.75) and CSF volume (MD: 5.00, 95% CI: −11.10 to 21.09, P = 0.54).The differences between HA and LA in FA values of frontotemporal lobes were not statistically significant: right frontal lobe (MD: −0.02, 95% CI: −0.07 to 0.03, P = 0.38), left frontal lobe (MD: 0.01, 95% CI: −0.02 to 0.04, P = 0.65), right temporal lobe (MD: −0.00, 95% CI: −0.03 to 0.02, P = 0.78) and left temporal lobe (MD: −0.01, 95% CI: −0.04 to 0.02, P = 0.62). However, there were significant differences in GM volume, GM density and FA values in local brain regions between HA group and LA group.ConclusionCompared with LA area, there were no significant differences in total GM, WM and CSF volumes in healthy people living at high-altitude area for long-term, while there were significant differences in GM volume and FA values in local brain regions. Long-term exposure to high-altitude area caused the adaptive structural changes in local brain regions. Since heterogeneity existed between the studies, further studies are needed to uncover the effects of high-altitude on brain of healthy people.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023403491.
Artificially Intelligent? Machine Learning in Healthcare and Why It May Not Be As Advanced As You Think
Authors: Choudhury Avishek , Allen Caitlyn 
Published: June 2023

Machine learning: What exactly is it, and how is it being used in healthcare? Are machines always better than a person? How do we know? Managing editor, Caitlyn Allen, sat down with Dr. Avishek Choudhury, artificial intelligence healthcare researcher, to answer these questions and more.
Precise Planar-Twisted Molecular Engineering to Construct Semiconducting Polymers with Balanced Absorption and Quantum Yield for Efficient Phototheranostics
Authors: Su Xiang , Bao Zhirong , Xie Wei , Wang Deliang , Han Ting , Wang Dong , Tang Ben Zhong 
Published: June 2023

Semiconducting polymers (SPs) have shown great feasibility as candidates for near-infrared-II (NIR-II) fluorescence imaging-navigated photothermal therapy due to their strong light-harvesting ability and flexible tunability. However, the fluorescence signal of traditional SPs tends to quench in their aggregate states owing to the strong π–π stacking, which can lead to the radiative decay pathway shutting down. To address this issue, aggregation-induced emission effect has been used as a rational tactic to boost the aggregate-state fluorescence of NIR-II emitters. In this contribution, we developed a precise molecular engineering tactic based on the block copolymerizations that integrate planar and twisted segments into one conjugated polymer backbone, providing great flexibility in tuning the photophysical properties and photothermal conversion capacity of SPs. Two monomers featured with twisted and planar architectures, respectively, were tactfully incorporated via a ternary copolymerization approach to produce a series of new SPs. The optimal copolymer (SP2) synchronously shows desirable absorption ability and good NIR-II quantum yield on the premise of maintaining typical aggregation-induced emission characteristics, resulting in balanced NIR-II fluorescence brightness and photothermal property. Water-dispersible nanoparticles fabricated from the optimal SP2 show efficient photothermal therapeutic effects both in vitro and in vivo. The in vivo investigation reveals the distinguished NIR-II fluorescence imaging performance of SP2 nanoparticles and their photothermal ablation toward tumor with prominent tumor accumulation ability and excellent biocompatibility.
Counter Hegemony of Matriarchy in The Black Family Race
Authors: Kharisma Sechan Rafayan 
Published: June 2023

The phenomenon of the black race in a world that is always depicted as a people who are cornered on the edge by short animated films. Hair Love is an American animated short film written and directed by Matthew A. Cherry. This animated short film was used by Matthew A. Cherry to respond to the discrimination and ugly stereotypes that occur in a black racial family, especially an African-American father. This research was conducted to determine how the counter hegemony matriarchy is depicted in the film Hair Love. The method used in this research is John Fiske's semiotics which is divided into 3 levels, namely; reality level consisting of code appearance, behavior, movement and expression; representation level consisting of camera code and characters; the ideological level found by the counter hegemony ideology against the matriarchy. The approach applied in this research is descriptive qualitative. From the results of this study, it is found that there is a counter hegemony and matriarchal ideology behind this short animated film. The practical matriarchal hegemony counter was launched in the film scene produced by Sony Animation. Show that the rejection of matriarchal domination is created to support black fathers / husbands to educate and nurture their children.

Keywords: Cons of Hegemony; Matriarchy; Black Race; Semiotics; Film
SISTEM PENGEMBANGAN MINAT BELAJAR SISWA DALAM PROSES PEMBELAJARAN DI SEKOLAH DASAR
Authors: Rahim Abdul , Yusnan Muhammad , Kamasiah Kamasiah 
Published: June 2023

Guru sebagai pengajar dalam proses pembelajaran yang dilaksanakan di sekolah bertujuan untuk dapat mewujudkan lahirnya siswa yang berkualitas dan salah satu faktor yang dapat mempengaruhi siswa berkualitas dalam proses pembelajaran adalah minat belajar siswa dimana bila tinggi minat belajar siswa pada suatu materi pelajaran yang diajarkan guru maka siswa dapat berprestasi maksimal dalam proses pembelajaran tetapi bila minat belajar siswa rendah maka hal itu akan mempengaruhi pada rendahnya prestasi Belajar siswa pada materi pelajaran yang diajarkan oleh guru. Untuk itu guru harus mampu mengoptimalkan kegiatan pembelajaran dengan baik sehingga minat belajar siswa menjadi tinggi pada materi pelajaran yang diajarkan dimana langkah yang harus dilakukan guru berupa guru harus mengelola metode mengajar secara optimal, guru harus menguasai dengan baik setiap materi pelajaran yang diajarkan, guru membekali dirinya dengan berbagai pengetahuan terkait bidang tugas dan guru harus mampu memahami dengan baik semua karakteristik siswanya
ANALISIS PELAKSANAAN PEMBELAJARAN DARING PADA MASA PANDEMI COVID 19 DI SD NEGERI TANOWALI KECAMATAN TOMIA KABUPATEN WAKATOBI
Authors: Ode Muhamad Nur Intan , Sari Amlia 
Published: June 2023

Analisis Pelaksanaan Pembelajaran Daring Pada Masa Pandemi Covid 19 di SD Negeri Tanowali Kecamatan Tomia Kabupaten Wakatobi. Tujuan penelitian ini adalah untuk mendeskripsikan pelaksanaan pembelajaran daring dan faktor pendukung dan penghambat pelaksanaan pembelajaran daring pada masa pandemi covid-19 di SD Negeri Tanowali. Penelitian ini menggunakan metode deskriptif kualitatif, dengan jenis penelitian fenomenologis. Hasil penelitian menggambarkan bahwa pelaksanaan pembelajaran daring pada masa pandemi covid-19 di SD Negeri Tanowali baik dilihat dari perencanaan, proses dan evaluasi hasil pembelajaran daring sudah terlaksana dengan cukup baik, Namun demikian pelaksanaan pembelajaran daring pada dasarnya belum mampu memberikan hasil pembelajaran yang maksimal. Hal ini dipengaruhi oleh faktor pendukung dan penghambat dalam pelaksanaan pembelajaran daring pada masa pandemi covid-19 di SD Negeri Tanowali yaitu kemampuan sumber daya manusia baik guru maupun siswa, jaringan internet, kecepatan, fleksibilitas, dukungan keluarga yang semuanya memiliki pengaruh terhadap pelaksanaan pembelajaran
HUBUNGAN PEMBERIAN REWARD (HADIAH) TERHADAP MINAT BELAJAR PADA SISWA SEKOLAH DASAR
Authors: Matje Irman 
Published: June 2023

Pembelajaran akan meninggalkan kesan baik pada saat siswa dapat mingkatkan minat belajarnya, salah satunya adalah keinginan untuk belajar dari siswa itu sendiri. Pemberian reward (hadiah) kepada siswa yang tidak hanya berupa barang berwujud, tetapi juga dalam bentuk pujian, acungan jempol, senyum bahagia, tepuk tangan, dan ungkapan persetujuan lainnya. Untuk meningkatkan minat belajar siswa di kelas, guru harus memberikan umpan balik, seperti hadiah, dengan cara yang sesuai dan efektif. Penelitian ini menggunakan metodologi penelitian kuantitatif yang meliputi pengumpulan data dengan menggunakan instrumen penelitian dan pengolahan data kuantitatif. Adapun instrument yang digunakan dalam penelitian ini adalah angket (kusioner). Sebanyak 50 siswa kelas V SD Negeri 3 Baubau yang menjadi subjek penelitian ini. Hasil penelitian ini menunjukan bahwa pemberian reward terhadap minat belajar siswa diketahui bahwa Ho diterima jika nilai signifikan deviation from linearity > 0.5 atau Ho ditolak jika nilai signifikan deviation from linearity > 0.5. Artinya terdapat hubungan pemberian reward terhadap minat belajar siswa kelas V SD Negeri 3 Baubau.
IMPLEMENTASI KARAKTER RELIGIUS PADA SISWA SEKOLAH DASAR ISLAM TERPADU INSAN CENDEKIA KOTA BAUBAU
Authors: Yahya Safaruddin 
Published: June 2023

Penelitian ini bertujuan mengetahui sejauh mana implementasi Karakter Religius di SD Islam Terpadu Insan Cendekia Kota Baubau. Dengan fokus penelitian mencakup : (1) Bagaimana Implementasi Karakter Religius pada Sekolah Dasar (2) Nilai-Nilai Karakter apa saja yang ditanamkan kepada siswa di sekolah, (3) Bagaimana Implikasi terhadap penanaman Karakter Religius pada siswa Sekolah Dasar. Penelitian ini merupakan penelitian kualitatif deskriptif. Pengumpulan data dilaksanakan dengan cara observasi, wawancara, dan dokumentasi. Analisis data dilakukan dengan cara memberi makna terhadap data yang telah berhasil dikumpulkan, dan dari pemaknaan data ini selanjutnya ditarik kesimpulan. Hasil penelitian ini menunjukkan bahwa: (1) Implementasi karakter religius terhadap siswa dilakukan secara bertahap mulai dari memadukan nilai-nilai Islam dalam setiap pembelajaran, membiasakan siswa mengikuti kegiatan keagamaan, melakukan pembinaan melalui kegiatan ekstrakurikuler. (2) nilai-nilai religius yang diimplementasikan kepada peserta didik di lingkungan sekolah diantaranya ialah nilai ketaatan menjalankan ibadah, menghormati guru, kejujuran, dan gemar berinfaq. (3) implikasi dari penanaman karakter religius berdampak pada pembentukan perilaku peserta didik yang tampak dalam kebiasaannya sehari-hari dalam hal berpikir secara positif, bertutur kata yang sopan serta bertindak sesuai dengan etika Islami
PENERAPAN MODEL PEMBELAJARAN SAVI (SOMATIC AUDITORI VISUAL INTELECTUAL) DALAM MENINGKATAN HASIL BELAJAR IPA MATERI PERKEMBANGBIAKAN TUMBUHAN PADA SISWA SEKOLAH DASAR
Authors: Sulistia Nadia Eka 
Published: June 2023

Penelitian ini adalah jenis Penelitian Tindakan Kelas yang dilakukan dengan dua siklus. Prosedur yang dipakai ialah tahap perencanaan tindakan, pelaksanaan tindakan, observasi, dan refleksi. Berdasarkan hasil observasi yang telah dilaksanakan oleh peneliti di SDN Socah 3, ditemukan bahwa ketika pembelajaran di kelas VI masih bersigat terintegritas, sehingga mengakibatkan cara berpikir dan kreatifitas siswa kurang berkembang. Pada saat pembelajaran IPA di kelas VI, guru ketika mengajar seringkali hanya menerapakan model pembelajaran diskusi ataupun ceramah. IPA merupakan ilmu yang mengkaji tentang peristiwa alam dengan melakukan sebuah penelitian, pengamatan, serta penggolongan teori supaya siswa memiliki pengetahuan. Oleh sebab itu, penelitian ini bertujuan guna meningkatkan hasil belajar siswa kelas VI pada mata pelajaran IPA dengan menerapkan model pembelajaran SAVI (Somatic, Auditory, Visual, Intellectual). Model pembelajaran SAVI adalah model pembelajaran melibatkan psikomotoriknya serta aktivitas berpikir menggunakan segala panca inderanya saat proses pembelajaran berlangsung. Teknik pengumpulan data yang dipakai ialah observasi, tes, dan dokumentasi. Sedangkan instrumen datanya ialah lembar observasi dan lembar soal. Berdasarkan uraian data menyatakan bahwa ada peningkatan mengenai hasil belajar siswa yang memperoleh persentase rata-rata 76% pada siklus I yang berarti bahwa terdapat 19 dari 25 orang siswa yang tuntas. Kemudian, mengalami peningkatan sebesar 96% pada siklus II yang artinya terdapat 24 dari 25 orang siswa yang tuntas secara klasikal. Berdasarkan uraian penelitian, bisa disimpulkan model pembelajaran SAVI ini bisa mengakibatkan adanya peningkatan terhadap hasil belajar siswa kelas VI khususnya di mata pelajaran IPA.