bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation on the structural and optical properties of MSA capped CdTe quantum dots
Authors: Borah Dibya Jyoti , Saikia D. , Das A. , Saikia P. K. , Mostako A.T.T. 
Published: February 2023

Abstract
In this work, a modified sonication induced wet chemical approach is adopted to synthesize highly luminescent and water soluble Cadmium Telluride (CdTe) quantum dots (QDs). Cadmium Chloride and Sodium Tellurite are used as the source of Cadmium and Tellurium. To limit the size of the QDs, Mercaptosuccinic acid is used as a capping agent. The refluxing time dependence on morphology, size, crystal structural, and optical properties of CdTe QDs are investigated. The refluxing time-dependent optical constants viz. band gap energy and Urbach energy of the QDs are estimated from UV-Vis absorption spectra. The fluorescence spectra of the QDs are also investigated by recording the spectra under the excitation wavelength at 320 nm. CdTe QDs are found to uniform in size. The average size of the QDs estimated from the HRTEM image analysis is about 5.8 nm and 8.2 nm for refluxing times 1 and 4 hours, respectively. The growth mechanism of the QDs as a function of refluxing time has also been discussed. Two phases of the CdTe QDs, namely hexagonal and cubic are confirmed from the HRTEM images and SAED patterns analysis. The phase transformation from hexagonal to cubic is successfully achieved by tuning the refluxing time from 1 to 4 hours.
Finite-Time Consensus of Heterogeneous Unmanned Aerial Agents in Network with Fixed and Switching Topology
Authors: Pal Madhumita , Mukherjee Amartya 
Published: February 2023

Abstract

A finite time consensus protocol is presented in this paper for a network of connected heterogeneous agents with fixed and switching topology. In this study, two cases directed networks with fixed topology and directed networks with switching topology are examined. Convergence analysis for both the cases are presented. An independent tracking controller, which assures that an agent follows an ideal trajectory designed by sliding mode based consensus control, is devised. Agents stability are independent of the distributed consensus algorithm. Under the proposed control methodology, the measurement vectors of heterogeneous agents converge to the agreement value in a finite amount of time. The comparison results with the existing works show the proposed algorithm's improved performance in terms of convergence time in presence of disturbances.
Salvage surgery after combination immunotherapy for initially unresectable hepatocellular carcinoma: A retrospective clinical study
Authors: Xue Jun-Shuai , Liu Hui , Li Rui-Zhe , Tan Si-Yu , Yan Yu-Chuan , Dong Zhao-Ru , Hong Jian-Guo , Liu En-Yu , Zhang Qiang-Bo , Chen Zhi-Qiang , Wang Dong-Xu , Li Tao 
Published: February 2023

Abstract
Background: Combination immunotherapy have gradually become the mainstay of systematic therapy for hepatocellular carcinoma (HCC), however, prescribing immunotherapies perioperatively has the potential to reduce tumor activity, while increasing the resection rate and improving prognoses. This study investigated the efficacy and safety of preoperative combined immunotherapies for patients with initially unresectable HCC.
Methods:This retrospective, real-world study involved patients with initially unresectable HCC receiving combined immunotherapies based on PD-1/L1 blockade before surgery. Tumor treatment responses, pathological manifestations in postoperative specimens and overall survival (OS) were evaluated. Treatment related adverse events (AEs) were assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE, version 4.0).
Results: The study consecutively included 54 initially unresectable HCC patients and 34 patients were evaluated the safety, efficacy and possibility of subsequent radical surgery. Among these patients with surgical resection, 57.1% (n=8) receiving combination immunotherapy before surgery achieved a partial response (PR), which highlighted a 30% reduction in tumor size. Pathological evaluation of postoperative specimens confirmed that 21.4% (n=3) achieved complete responses. 78.6% (n=11) achieved partial responses. 28.6% (n=4) encountered grade 3 or 4 AEs out of 14 patients. The main AEs included fatigue (n=11; 78.6%), leukocytopenia (n=8; 57.1%,) and aspartate aminotransferase (AST) elevation (n=6; 42.9%).
Conclusions: After the application of combination immunotherapy, patients should be comprehensively evaluated whether they meet the criteria for surgical resection. This surgical resection following by combination immunotherapy might effectively control tumor progression and could improve the prognosis at least for some patients with initially unresectable HCC.
Limitations of gravity models in predicting fine-scale spatial-temporal urban mobility networks
Authors: Hsu Chia-Wei , Fan Chao , Mostafavi Ali 
Published: February 2023

Abstract
This study identifies the limitations and underlying characteristics of urban mobility networks that influence the performance of the gravity model. The gravity model is a widely-used approach for estimating and predicting population flows in urban mobility networks. Prior studies have reported very good performance results for the gravity model as they tested it using origin-destination (O-D) data at certain levels of aggregation. Also, the main premise of the gravity model in urban networks is the existence of the scale-free property. The characteristics of urban mobility networks, such as scale-free properties, network size, the existence of hubs and giant components, however, might vary depending on the spatial and temporal resolutions of data based on which these networks are constructed. Hence, the sensitivity of gravity model performance to variation in the level of aggregation of data and the temporal and spatial scale of urban mobility networks needs to be examined. To address this gap, this study examined the basic gravity model, which captures the flow magnitude between O-D pairs based on three variables (population of the origin, population of the destination, and the distance between them). Accordingly, we constructed the urban mobility networks using fine-grained location-based human mobility data for multiple US metropolitan counties. The constructed urban mobility networks have finer resolution as they capture population flow among census tracts on an hourly and daily scale (as opposed to previous studies which used larger spatial blocks). The results show that the scale-free property does not always exist when urban mobility networks are constructed from data with finer spatial and temporal resolution. By examining the association between macroscopic network characteristics, such as the number of nodes and links, average degree, average clustering coefficient, assortativity coefficient, and predictive performance, we found weak association between performance and certain network structures. The findings suggest that: (1) finer-scale urban mobility networks do not demonstrate a scale-free property; (2) the performance of the basic gravity model decays for predicting population flow in the finer-scale urban mobility networks; (3) the variations in population density distribution and mobility network structure and properties across counties do not significantly influence the performance of gravity models. Hence, gravity models may not be suitable for modeling urban mobility networks with daily or hourly aggregation of census tract to census tract movements. The findings highlight the need for new-generation urban mobility network models or machine learning approaches to better predict fine-scale and high temporal-resolution urban mobility networks.
EMMY: The continued expansion of clinical applications of SGLT2 inhibitors
Authors: Kotit Susy 
Published: February 2023

Study and Results: The EMMY trial was conducted to assess the safety and efficacy of empagliflozin in patients with acute myocardial infarction (AMI). A total of 476 patients with AMI were randomly assigned to empagliflozin (10 mg) or matching placebo once daily within 72 h of percutaneous coronary intervention. The primary outcome was the N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP) change over 26 weeks. Secondary outcomes included changes in echocardiographic parameters. NT-proBNP reduction was significantly greater in the empagliflozin group (-15% after adjusting for baseline NT-proBNP, gender, and diabetes status (P=0.026)). Absolute left-ventricular ejection fraction improvement was 1.5% (P = 0.029) greater, mean E/e′ reduction was 6.8% (P = 0.015) greater, and left-ventricular end-systolic and end-diastolic volumes were lower by 7.5 mL (P = 0.0003) and 9.7 mL (P =0.0015), respectively, in the empagliflozin group, compared with placebo. Seven patients were hospitalized for HF (3 in the empagliflozin group). Other predefined serious adverse events were rare and did not differ significantly between groups.
Molecular autopsy in sudden cardiac death
Authors: Campuzano Oscar , Sarquella-Brugada Georgia 
Published: February 2023

A post-mortem genetic analysis in the process of investigating a sudden death episode is known as ‘molecular autopsy’. It is usually performed in cases without a conclusive cause of death and after a comprehensive medico-legal autopsy. In these sudden unexplained death cases, an underlying inherited arrhythmogenic cardiac disease is the main suspected cause of death. The objective is to unravel a genetic diagnosis of the victim, but it also enables cascade genetic screening of the victim’s relatives. Early identification of a deleterious genetic alteration associated with an inherited arrhythmogenic disease may help to adopt preventive personalized measures to reduce risk of malignant arrhythmias and sudden death. It is important to remark that the first symptom of an inherited arrhythmogenic cardiac disease may the malignant arrhythmia and even sudden death. Next-generation sequencing allows a rapid and cost-effectives genetic analysis. Close interaction between the forensic scientist, pathologist, cardiologist, pediatric cardiologist and geneticist has allowed a progressive increase of genetic yield in recent years, identifying the pathogenic genetic alteration. However, large numbers of rare genetic alterations remain classified as having an ambiguous role, impeding a proper genetic interpretation and useful translation into both forensic and cardiological arena.
In-situ experiment research on environmental vibration transmission characteristics of air-rail combined airport
Authors: Wu Zaixin , Dai Feng , Yang Jizhong 
Published: February 2023

The rail transit and civil aviation are the important components of the comprehensive transportation system. The development of the air-rail combined transport is an important effective way for China to become a country with strong transportation network. The transportation intersection form of railway under-passing airport transportation hub gradually becomes popular, thus the environmental vibration due to the under-passing railway cannot be ignored. In this paper, a large-scale integrated transportation hub construction project was taken as an example to analyze the transmission rule of environmental vibration due to the high-speed railway at the speed of 350 km/h under-passing airport in terms of the time domain and frequency domain by means of the on-site in-situ wheel-drop test. The research results show that the vertical vibration response of the ground surface along the normal direction of the railway is greater than those of the other two directions within 40 m from the centerline of the track. A vibration amplification zone appears within 5-40 m. The longitudinal vibration response of the ground surface is greater than those of the other two directions within 40-70 m. The local vibration amplification zones appear within 5-20 m and 30-60 m. The lateral vibration level of the ground surface along the normal direction of the railway increase gradually, but attenuates at the distance of 40 m and 10 m with the maximum attenuation rate of 0.67. The vertical vibration level amplifies at the distance of 60 m. The longitudinal vibration level attenuates at the distance of 20 m with the maximum attenuation rate of 0.3, but amplifies at the distance of 40 m with the maximum amplification rate of 1.8.
Folate Pathway Inhibitors, An Underestimated and Underexplored Molecular
Target for New Anti-tuberculosis Agents
Authors: Vassiliades Sandra Valeria , Borges Lara Gimenez , Giarolla Jeanine , Parise-Filho Roberto 
Published: February 2023

Abstract:
The folate metabolic cycle is an important biochemical process for the maintenance of cellular
homeostasis, and is a widely studied pathway of cellular replication control in all organisms. In
microorganisms such as M. tuberculosis (Mtb), for instance, dihydrofolate reductase (MtDHFR) is the
enzyme commonly explored as a molecular target for the development of new antibiotics. In the same
way, dihydropteroate synthase (MtDHPS) was studied extensively until the first multidrug-resistant
strains of mycobacteria that could not be killed by sulfonamides were found. However, the other enzymes
belonging to the metabolic cycle, until recently less explored, have drawn attention as potential
molecular targets for obtaining new antituberculosis agents. Recent structural determinations and
mechanism of action studies of Mtb flavin-dependent thymidylate synthase (MtFDTS) and MtRv2671,
enzymes that acts on alternative metabolic pathways within the folate cycle, have greatly expanded
the scope of potential targets that can be screened in drug design process. Despite the crystallographic
elucidation of most cycle proteins, some enzymes, such as dihydrofolate synthase (MtDHFS) and serine
hydroxylmethyltransferase (MtSHMT), remain underexplored. In this review, we highlight recent
efforts towards the inhibitor design to achieve innovative antituberculosis agents and a brief history of
all enzymes present in the folate metabolic cycle. In the final section of this work, we have presented
the main synthetic strategies used to obtain the most promising inhibitors.
Compliance With the US Food and Drug Administration’s Guidelines for Health Warning Labels and Engagement in Little Cigar and Cigarillo Content: Computer Vision Analysis of Instagram Posts
Authors: Wu Jiaxi , Origgi Juan Manuel , Ranker Lynsie R , Bhatnagar Aruni , Robertson Rose Marie , Xuan Ziming , Wijaya Derry , Hong Traci , Fetterman Jessica L 
Published: February 2023

Background
Health warnings in tobacco advertisements provide health information while also increasing the perceived risks of tobacco use. However, existing federal laws requiring warnings on advertisements for tobacco products do not specify whether the rules apply to social media promotions.

Objective
This study aims to examine the current state of influencer promotions of little cigars and cigarillos (LCCs) on Instagram and the use of health warnings in influencer promotions.

Methods
Instagram influencers were identified as those who were tagged by any of the 3 leading LCC brand Instagram pages between 2018 and 2021. Posts from identified influencers, which mentioned one of the three brands were considered LCC influencer promotions. A novel Warning Label Multi-Layer Image Identification computer vision algorithm was developed to measure the presence and properties of health warnings in a sample of 889 influencer posts. Negative binomial regressions were performed to examine the associations of health warning properties with post engagement (number of likes and comments).

Results
The Warning Label Multi-Layer Image Identification algorithm was 99.3% accurate in detecting the presence of health warnings. Only 8.2% (n=73) of LCC influencer posts included a health warning. Influencer posts that contained health warnings received fewer likes (incidence rate ratio 0.59, P<.001, 95% CI 0.48-0.71) and fewer comments (incidence rate ratio 0.46, P<.001, 95% CI 0.31-0.67).

Conclusions
Health warnings are rarely used by influencers tagged by LCC brands’ Instagram accounts. Very few influencer posts met the US Food and Drug Administration’s health warning requirement of size and placement for tobacco advertising. The presence of a health warning was associated with lower social media engagement. Our study provides support for the implementation of comparable health warning requirements to social media tobacco promotions. Using an innovative computer vision approach to detect health warning labels in influencer promotions on social media is a novel strategy for monitoring health warning compliance in social media tobacco promotions.
Penerapan pengadaan bahan makanan di dapur the cakra hotel bali
Authors: Arisuta I Kadek 
Published: February 2023

Pada sebuah hotel yang memiliki restoran, sangat diperlukan adanya supplier pengadaan bahan-bahan makanan untuk department dapur pada sebuah restoran tersebut, seperti pada industri The Cakra Hotel Bali. Namun dari hasil pengamatan yang diperoleh terdapat adanya beberapa indikasi kurangnya penerapan pengadaan bahan-bahan makanan di dapur. Tujuan penelitian ini adalah untuk mengetahui penerapan pengadaan bahan makanan di dapur The Cakra Hotel Bali. Dalam penelitian ini, penulis ingin membandingkan bagaimana penerapan pengadaan bahan makanan yang ada di dapur The Cakra Hotel Bali sesuai Standard Operational Procedure (SOP) dengan kenyataan yang terjadi, apakah sudah sesuai atau tidak. Teknik pengumpulan data dilakukan dengan cara observasi, wawancara, dan dokumentasi. Teknik analisis yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Pada penelitian yang telah dilakukan, penulis menemukan beberapa masalah terkait penerapan pengadaan bahan makanan yang masih terjadi di hotel tersebut. Hasil penelitian menunjukkan bahwa Standard Operational Procedure belum berjalan dengan maksimal. Evaluasi serta pelatihan perlu dilakukan untuk meningkatkan penerapan SOP menjadi lebih baik dari sebelumnya.

In a Hotel that has a restaurant, it is very necessary to have a supplier of procurement food ingredients in the kitchen department at a restaurant, like in industry The Cakra Hotel Bali. But, from the observations obtained there are several indications of the lack application of food procurement in the kitchen. The purpose of this study was to determine the application of food procurement in the kitchen The Cakra Hotel Bali. In this study, the authors want to compare how the implementation of the procurement of food ingredients in the kitchen of The Cakra Hotel Bali, according to Standard Operating Procedures (SOP) with the reality that occurs, whether it is appropriate or not. Data collection techniques are carried out by means of Observation, Interviews and Documentation. The analytical technique used in this research is Descriptive qualitative. In the research that has been done the author found several problems related to the implementation of food procurement ingredients that still occurs in the hotel. The results of the study indicate that the Standard Operating Procedures (SOP), have not running optimally. Evaluation and training need to be carried out to improve the implementation of Standard Operating Procedures (SOP) to be better than before.
Pembuatan sorbet lemon subtitusi daun cincau hijau
Authors: Artawan Kadek Yuda Dwi 
Published: February 2023

Sorbet adalah produk buah-buahan yang dibekukan yang biasanya berupa makanan pencuci mulut dessert yang terbuat dari sari pati puree, simple syrup, lemon juice dan dibuat tanpa penambahan produk yang berasal dari hewani. Sorbet pada umumnya terbuat dari berbagai macam buah-buahan. Sehingga membuat penulis tertarik untuk mencoba dan mengetahui hal baru dengan menggunakan daun cincau hijau untuk pembuatan sorbet. Penelitian ini bertujuan untuk mengetahui kualitas organoleptik sorbet lemon subtitusi daun cincau hinjau, ditinjau dari segi rasa, warna, aroma, tekstur, daya tahanserta biaya produksi yang dibutuhkan. Penelitian ini menggunakan jenis data kuantitatif dengan pendekatan penelitian eksperimen. Hasil Uji organoleptik menunjukkan bahwa pembuatan sorbet lemon subtitusi daun cincau hijau merupakan campuran terbaik dengankualitas rasa sangat enak, tekstur lembut, warna menarik, serta aroma yang khas dari daun cincau hijau. Sorbet lemon subtitusi daun cincau hijau mendapat interprestasi baik dari masyarakat serta menambah pengetahuan dan wawasan mereka.

Sorbet is a frozen fruit product which is usually a dessert made from puree starch, simple syrup, lemon juice and made without the addition of products of animal origin. The sorbet is made from a variety of fruits. So that makes the writer interested in trying and knowing new things by using green grass jelly leaf for making sorbet. This study aims to determine the organoleptic quality of lemon sorbet substituted with green grass jelly leaf, in terms of taste, color, aroma, texture, durability and required production costs. This study uses quantitative data types with an experimental research approach. The results of the organoleptic test showed that the manufacture of green grass jelly leaf substituted lemon sorbet was the best mixture with very good taste quality, soft texture, attractive color, and a distinctive aroma from green grass jelly leaves. Lemon sorbet substituted with green grass jelly leaves received good interpretations from the community and increased their knowledge and insight.
The Influence of Saliva and Blood Contamination on Bonding Between Resin-modified Glass Ionomer Cements and Resin Composite
Authors: Mar B , Ekambaram M , Li KC , Zwirner J , Mei ML 
Published: February 2023

SUMMARYObjectiveTo investigate the influence of blood and saliva contamination on the microshear bond strength (μSBS) between resin-modified glass ionomer cement (RMGIC) and resin composite (RC).Methods and MaterialsEighty RMGIC discs were allocated into four groups (n=20). Group 1 received universal dental adhesive application in a self-etch mode followed by a build-up with RC. Group 2 received saliva as a contaminant, Group 3 received blood as a contaminant, Group 4 received a 1:1 blood-saliva mixture as a contaminant. Specimens from Groups 2, 3, and 4 were submerged into their respective contaminants for 15 seconds and dried prior to the adhesive application, followed by the protocol for Group 1. All specimens were stored in distilled water for 24 hours. Subsequently, the bonded specimens were subjected to μSBS testing using a universal testing machine. Failure mode of the debonded RMGIC surfaces was examined using scanning electron microscopy.ResultsThe μSBS from groups 1–4 were 10.76 ± 3.03 MPa, 9.36 ± 2.54 MPa, 6.55 ± 1.67 MPa and 8.42 ± 2.79 MPa, respectively. Contamination by blood and blood-saliva significantly decreased the μSBS (p&lt;0.001, p=0.029). Saliva contamination alone had no statistically significant effect on the μSBS (p=0.524). A statistically significant difference in the mode of failure was detected between the experimental groups (p=0.012).ConclusionSaliva contamination has no influence on μSBS between RMGIC and RC when it is dried thoroughly, while blood and blood-saliva contamination reduced μSBS between RMGIC and RC even when dried thoroughly.