bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical impact of a celiac axis stenosis in patients undergoing hepatobiliary surgery
Authors: Bieniek Pawel A. , Katou Shadi , Kraehling Hermann , Masthoff Max , Morgul Haluk , Pascher Andreas , Struecker Benjamin 
Published: July 2023

Abstract
Background
Celiac axis stenosis (CAS) often is an incidental finding in terms of diagnostic for hepatobiliary surgery since most cases remain asymptomatic. It remains unclear whether CAS is a risk factor for postoperative complications after hepatobiliary surgery. Therefore, the aim of this study was to evaluate the impact of an asymptomatic CAS on the postoperative morbidity and survival of patients undergoing hepatobiliary surgery.

Methods
We retrospectively analyzed CT scans and clinicopathological data of 250 consecutive patients undergoing hepatobiliary surgery between 2011 and 2018 in our tertiary center. We compared the postoperative course between patients with and without an incidental CAS as well as their overall survival.

Results
CAS was caused by atherosclerotic stenosis in 16 (64%) patients, by ligamentous stenosis in 4 (16%) and by combined conditions in 5 cases (20%). Mean age of patients in the CAS group was significantly higher in comparison to patients of the non-CAS group (71.0 vs. 59.1 years, p < 0.001). Major hepatectomy was conducted in 40% of the CAS patients and 19.6% of non-CAS patients, respectively (p = 0.036). Interestingly, no statistically significant differences in postoperative morbidity (40 vs. 46.2%, p = 0.673) or in overall survival between the groups (41.3 vs. 51.9 months, p = 0.611) were observed.

Conclusion
Our analysis found no correlation between an asymptomatic celiac axis stenosis and postoperative complications or overall survival after hepatobiliary surgery. Which impact the incidental CAS may have in highly complex cases remains unclear. Further studies are needed to identify patients who benefit from CAS treatment before hepatobiliary surgery.
Prospective phenotyping of CHAMP1 disorder indicates that coding mutations may not act through haploinsufficiency
Authors: Levy Tess , Pichardo Thariana , Silver Hailey , Lerman Bonnie , Zweifach Jessica , Halpern Danielle , Siper Paige M. , Kolevzon Alexander , Buxbaum Joseph D. 
Published: July 2023

AbstractCHAMP1 disorder is a genetic neurodevelopmental condition caused by mutations in the CHAMP1 gene that result in premature termination codons. The disorder is associated with intellectual disability, medical comorbidities, and dysmorphic features. Deletions of the CHAMP1 gene, as part of 13q34 deletion syndrome, have been briefly described with the suggestion of a milder clinical phenotype. To date, no studies have directly assessed differences between individuals with mutations in CHAMP1 to those with deletions of the gene. We completed prospective clinical evaluations of 16 individuals with mutations and eight with deletions in CHAMP1. Analyses revealed significantly lower adaptive functioning across all domains assessed (i.e., communication, daily living skills, socialization, and motor skills) in the mutation group. Developmental milestones and medical features further showed difference between groups. The phenotypes associated with mutations, as compared to deletions, indicate likely difference in pathogenesis between groups, where deletions are acting through CHAMP1 haploinsufficiency and mutations are acting through dominant negative or gain of function mechanisms, leading to a more severe clinical phenotype. Understanding this pathogenesis is important to the future of novel therapies for CHAMP1 disorder and illustrates that mechanistic understanding of mutations must be carefully considered prior to treatment development.
Examining the Outcomes of Project ECHO® as an Interprofessional Community of Practice for Pediatric Feeding Clinicians
Authors: Raatz Madeline , Ward Elizabeth C. , Moss Perrin , Reilly Claire , Frederiksen Nadine , Dickinson Corrine , Clarke Sally , Beak Kelly , Marshall Jeanne 
Published: July 2023

AbstractProject ECHO® is a virtual, interprofessional, cased-based peer-learning model. To date, no studies have explored ECHO as a model for pediatric feeding education. This study examined the outcomes of establishing a pediatric feeding ECHO network. Using a prospective, mixed-methods design, two cohorts of allied health professionals were recruited. Each cohort participated in eight, 90-min videoconference sessions incorporating a didactic presentation and clinical case presentation. The case was presented by a participant, with questions and recommendations provided by the ECHO network. Participants completed: (1) a learning needs analysis before the ECHO series, (2) a self-reported confidence questionnaire pre, post, and 3-month post, (3) a satisfaction questionnaire after each session, and (4) an overall satisfaction questionnaire post-ECHO series. Time spent by hospital allied health clinicians providing impromptu phone/email feeding support to external clinicians was recorded for 8 weeks prior to and 8 weeks during the ECHO series. Forty-seven participants were included in the study, attending an average of 5.8 sessions. Significant improvements in self-reported confidence were observed across the three time points (p < 0.01) with less experienced participants demonstrating greater improvements. Participants reported high satisfaction with ECHO, with 93% (40/43) wanting continued access to ECHO in future. The multidisciplinary format, interactivity, structure, and case-based nature of ECHO were considered beneficial. A 75% reduction in requests for support from clinicians in the same catchment area was noted during the ECHO series. Results demonstrated that Project ECHO is a viable model for pediatric feeding education for clinicians working in the field. Further research is needed to investigate the long-term effects and impacts on clinical care.
Circulating hormones and risk of gastric cancer by subsite in three cohort studies
Authors: Sanikini Harinakshi , Biessy Carine , Rinaldi Sabina , Navionis Anne-Sophie , Gicquiau Audrey , Keski-Rahkonen Pekka , Kiss Agneta , Weinstein Stephanie J. , Albanes Demetrius , Agudo Antonio , Jenab Mazda , Riboli Elio , Gunter Marc J. , Murphy Gwen , Cross Amanda J. 
Published: July 2023

Abstract
Background
Obesity has been positively associated with gastric cancer. Excess fat impacts hormones, which have been implicated in carcinogenesis. We investigated obesity-related hormones and cardia gastric cancer (CGC) and non-cardia gastric cancer (NCGC) risk.

Methods
Nested case–control studies were conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (61 CGCs, and 172 NCGCs and matched controls) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study (100 CGCs and 65 NCGCs and matched controls); serum hormones were measured. In UK-Biobank (n = 458,713), we included 137 CGCs and 92 NCGCs. Sex-specific analyses were conducted. For EPIC and ATBC, odds ratios (ORs), and for UK-Biobank hazard ratios (HRs), were estimated using conditional logistic regression and Cox regression, respectively.

Results
Insulin-like growth-factor-1 was positively associated with CGC and NCGC in EPIC men (ORper 1-SD increase 1.94, 95% CI 1.03–3.63; ORper 1-SD increase 1.63, 95% CI 1.05–2.53, respectively), with similar findings for CGC in UK-Biobank women (HRper 1-SD increase 1.76, 95% CI 1.08–2.88). Leptin in EPIC men and C-peptide in EPIC women were positively associated with NCGC (ORT3 vs. T1 2.72, 95% CI 1.01–7.34 and ORper 1-SD increase 2.17, 95% CI 1.19–3.97, respectively). Sex hormone-binding globulin was positively associated with CGC in UK-Biobank men (HRper 1-SD increase 1.29, 95% CI 1.02–1.64). Conversely, ghrelin was inversely associated with NCGC among EPIC and ATBC men (ORper 1-SD increase 0.53, 95% CI 0.34–0.84; ORper 1-SD increase 0.22, 95% CI 0.10–0.50, respectively). In addition, dehydroepiandrosterone was inversely associated with CGC in EPIC and ATBC men combined.

Conclusions
Some obesity-related hormones influence CGC and NCGC risk.
Numerical investigation of transmission probability characteristics in the first low-density region of a laser wakefield accelerator
Authors: John Benzi , Middleman Keith , Malyshev Oleg B. , Gu Xiaojun , Symes Daniel R. , Emerson David R. 
Published: July 2023

AbstractTransmission probability is an important parameter in vacuum science and technology that needs to be accurately characterised for system design. Typically, this is computed using the test particle Monte Carlo method. However, this approach is valid only in the free molecular regime. In this work, we propose a methodology to compute transmission probability using the direct simulation Monte Carlo method, which makes possible the characterisation of vacuum devices for a wider range of operating pressure conditions from viscous to molecular flow regimes. This is applied to study the gas expansion characteristics in the first low-density drift region of a laser wakefield accelerator. Validations are first made by comparing the results against the test particle Monte Carlo method in the free molecular regime. The transmission probability is then characterised for a wide range of operating conditions, revealing interesting insights helpful towards not only a fundamental understanding but also in making design considerations.
Comparing computational algorithms for team formation in the classroom: a classroom experience
Authors: Sanchez-Anguix Victor , Alberola Juan M. , Del Val Elena , Palomares Alberto , Teruel Maria Dolores 
Published: July 2023

AbstractThroughout recent years, several researchers have proposed computational tools and algorithms to support team formation in the classroom. The result is that team formation algorithms have been widely applied in classroom environments to create well-balanced teams. One of the challenges in designing algorithms for automatic team formation is designing an appropriate function to estimate team performance, which is used as part of the optimization algorithm that divides students into teams. This function (referred to as a team evaluation heuristic) serves as an approximation to team performance, which is a complex phenomenon that is difficult to quantitatively assess in many settings and that cannot be accurately calculated prior to the task at hand. Despite showing their relative success compared to traditional and manual team formation strategies (manually employed by lecturers and teachers), there is a lack of research comparing team evaluation heuristics in a real classroom setting. Such a comparison would help teachers, practitioners, and system designers to appropriately select the most suitable team formation algorithms. In this article, we present an experimental evaluation that was carried out in a Bachelor’s Degree Program in Tourism that compares two team evaluation heuristics based on Belbin and Myer-Briggs. The experimental evaluation was carried out by means of an intelligent, extensible team formation tool whose optimization is based on an integer linear model that can be extended to support different team evaluation heuristics.
Running Out of Bank Runs
Authors: Libich Jan , Nguyen Dat Thanh , Kiss Hubert Janos 
Published: July 2023

AbstractThe theoretical literature on bank runs has modeled depositors’ withdrawal decision as a one-off choice, made simultaneously by all depositors. Our game-theoretic framework gives depositors a heterogeneous, stochastic opportunity to change their minds about withdrawing their money. They can run out of (or run into) the crowd in front of the bank based on their observation of what others have done. Depositors’ opportunity to change their decision supports implicit coordination, which in some circumstances reduces the probability that self-fulfilling bank runs will occur.
Trophic ecology of common bottlenose dolphins in a pelagic insular environment inferred by stable isotopes
Authors: Dias Ester , Dromby Morgane , Ferreira Rita , Gil Ágatha , Tejerina Raquel , Castro L. Filipe C. , Rosso Massimiliano , Sousa-Pinto Isabel , Hoffman Joel C. , Teodósio Maria A. , Dinis Ana , Alves Filipe 
Published: July 2023

AbstractThe common bottlenose dolphin (Tursiops truncatus) is a top marine predator widely dispersed in coastal and pelagic habitats and with a generalist feeding behavior. Yet, information on the trophic ecology of animals inhabiting pelagic environments is still scarce. Using carbon (δ13C: 13C/12C) and nitrogen (δ15N: 15N/14N) stable isotope ratios, we identified and quantified the main groups of prey assimilated by bottlenose dolphins inhabiting an oceanic habitat (Madeira Island, East Atlantic). Bottlenose dolphins assimilated pelagic, schooling fish (such as blue jack mackerel, Trachurus picturatus) and mesopelagic and demersal squids, which reinforces the pelagic dietary composition of insular/oceanic dolphins. Also, intra-seasonal differences were found in their stable isotope ratios, which suggest intraspecific variability in the feeding behavior among individuals living in the same area. Sex was not the main factor contributing to these differences, suggesting the lack of trophic niche segregation between adult males and females in this offshore environment. Nonetheless, further studies including different life stages and information on the ecophysiological requirements are necessary to disclose the factors responsible for the observed variability. This study showed that insular dolphins fed primarily on economically important pelagic prey, highlighting the need of developing management strategies that integrate conservation in fisheries plans.
Correlating the Density and Refractive Index of Ternary Liquid Mixtures
Authors: Dzingai Pethile , Focke Walter W. , Ramjee Shatish , Khosa Pretty , Nobunga Ripfumelo A. 
Published: July 2023

AbstractSome physical properties of ideal solutions, e.g. the molar volume and the molar refraction, vary linearly with composition. Others can be expressed, either as ratios or as products of two other properties which vary with composition in this way. It is postulated that the non-ideal behaviour of real solutions can be adequately modelled by substituting these linear functions with higher order Scheffé polynomials. A suite of such models is presented for which the parameters are fully determined by knowledge of pure component properties and binary behaviour. Their binary data representation ability, and capacity to predict ternary properties, was tested using density and refractive index data for the acetic acid–ethanol-water ternary system as well as fourteen additional ternary data sets. Model performance was ranked on the basis of the Akaike Information criterion. With respect to predicting ternary density and refractive index behaviour from knowledge of binary data, it was found that lower-order models outperformed higher order models.
Model reduction for nonlinearizable dynamics via delay-embedded spectral submanifolds
Authors: Axås Joar , Haller George 
Published: July 2023

AbstractDelay embedding is a commonly employed technique in a wide range of data-driven model reduction methods for dynamical systems, including the dynamic mode decomposition, the Hankel alternative view of the Koopman decomposition (HAVOK), nearest-neighbor predictions and the reduction to spectral submanifolds (SSMs). In developing these applications, multiple authors have observed that delay embedding appears to separate the data into modes, whose orientations depend only on the spectrum of the sampled system. In this work, we make this observation precise by proving that the eigenvectors of the delay-embedded linearized system at a fixed point are determined solely by the corresponding eigenvalues, even for multi-dimensional observables. This implies that the tangent space of a delay-embedded invariant manifold can be predicted a priori using an estimate of the eigenvalues. We apply our results to three datasets to identify multimodal SSMs and analyse their nonlinear modal interactions. While SSMs are the focus of our study, these results generalize to any delay-embedded invariant manifold tangent to a set of eigenvectors at a fixed point. Therefore, we expect this theory to be applicable to a number of data-driven model reduction methods.
Use of the gonadal tissue of the sea urchin Paracentrotus lividus as a target for environmental contamination by trace metals
Authors: Sarly Monique S. , Pedro Carmen A. , Bruno Catarina S. , Raposo Andreia , Quadros Helenita C. , Pombo Ana , Gonçalves Sílvia C. 
Published: July 2023

AbstractMany environmental monitoring works have been carried out using biomarkers as a tool to identify the effects of oil contamination on marine organisms; however, only a few studies have used sea urchin gonadal tissue for this purpose. Within this context, the present work aimed to understand the impact of an oil spill, proposing the use of sea urchin gonadal tissue as a biomarker for environmental contamination by trace metals in the species Paracentrotus lividus. Biometric analysis, quantification analyses of the elements Cd, Pb, Ni, Fe, Mn, Zn, and Cu, as well as histopathological evaluations were performed in gonads of P. lividus collected from an area affected by hydrocarbons, named as impacted shore (IS) and an area not affected, named reference shore (RS). The results showed that carapace diameter (DC), total wet weight (WW), and Cd concentrations in the gonads were significantly influenced by the interaction between the rocky shores of origin, the months of sampling, and by the sex of the individuals. Moreover, from July until September, the levels of Zn and Cd were significantly lower in male than in female gonads. In July (the month of the oil spill), the indexes of histopathological alterations (IHPA) of membrane dilation were significantly higher in individuals from the IS, compared to the individuals from the RS. In addition, there were significant correlations between biometric variables (wet weight, diameter of carapace, gonadal weight, and gonadosomatic index) and the elements Cd, Cu, Ni, and Mn concentrations. Lastly, a delay in the gametogenic cycle of the sea urchins from IS was also observed. Taken together, these findings suggest that direct exposure to trace metals induces histopathological lesions in P. lividus’ gonads and affects its reproductive cycle.
Graphical Abstract
Linking FDI and trade network topology with the COVID-19 pandemic
Authors: Antonietti Roberto , De Masi Giulia , Ricchiuti Giorgio 
Published: July 2023

AbstractGlobalization has considerably increased the movement of people and goods around the world, which constitutes a key channel of viral infection. Increasingly close economic links between countries speeds up the transfer of goods and information, and the knock-on effect of economic crises, but also the transmission of diseases. Foreign direct investment (FDI) and trade establish clear ties between countries of origin and destination, and it is along these chains that contagious phenomena can unfold. In this paper, we investigate whether countries’ centrality in both global production and trade network corresponds to higher COVID-19 infection and mortality rates. Merging data on EU-27 greenfield FDI and international trade with data on COVID-19 infections and deaths, we find that countries mostly exposed to the COVID-19 outbreak are those characterized by a higher eigenvector centrality. This result is robust to the use of an alternative measure of network centrality and to the inclusion of other possible confounding factors.
Accuracy of on-site teleoperated milling with haptic assistance
Authors: Drobinsky Sergey , de la Fuente Matías , Puladi Behrus , Radermacher Klaus 
Published: July 2023

Abstract
Purpose
In bone surgery specialties, like orthopedics, neurosurgery, and oral and maxillofacial surgery patient safety and treatment success depends on the accurate implementation of computer-based surgical plans. Unintentional plan deviations can result in long-term functional damage to the patient. With on-site teleoperation, the surgeon operates a slave robot with a physically-decoupled master device, while being directly present at the operation site. This allows the surgeon to perform surgical tasks with robotic accuracy, while always remaining in the control loop.

Methods
In this study the master- and slave-side accuracy of an on-site teleoperated miniature cooperative robot (minaroHD) is evaluated. Master-side accuracy is investigated in a user study regarding scale factor, target feed rate, movement direction and haptic guidance stiffness. Scale factors are chosen to correspond to primarily finger, hand, and arm movements. Slave-side accuracy is investigated in autonomous milling trials regarding stepover, feed rate, movement direction, and material density.

Results
Master-side user input errors increase with increasing target feed rate and scale factor, and decrease with increasing haptic guidance stiffness. Resulting slave-side errors decrease with increasing scale factor and are < 0.07 mm for optimal guidance parameters. Slave-side robot position errors correlate with the feed rate but show little correlation with stepover distance. For optimal milling parameters, the 95th percentile of tracked slave-side position error is 0.086 mm with a maximal error of 0.16 mm.

Conclusion
For optimal guidance and milling parameters, the combined error of 0.23 mm is in the range of the dura mater thickness (< 0.27 mm) or mandibular canal wall (~ 0.85 mm). This corresponds to safety margins in high-demand surgical procedures like craniotomies, laminectomies, or decortication of the jaw. However, for further clinical translation, the performance and usability of on-site teleoperated milling must be further evaluated for real-life clinical application examples with consideration of all error sources in a computer-assisted surgery workflow.
Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations
Authors: Portincasa Piero , Di Ciaula Agostino , Bonfrate Leonilde , Stella Alessandro , Garruti Gabriella , Lamont John Thomas 
Published: July 2023

AbstractAbout 20% of adults worldwide have gallstones which are solid conglomerates in the biliary tree made of cholesterol monohydrate crystals, mucin, calcium bilirubinate, and protein aggregates. About 20% of gallstone patients will definitively develop gallstone disease, a condition which consists of gallstone-related symptoms and/or complications requiring medical therapy, endoscopic procedures, and/or cholecystectomy. Gallstones represent one of the most prevalent digestive disorders in Western countries and patients with gallstone disease are one of the largest categories admitted to European hospitals. About 80% of gallstones in Western countries are made of cholesterol due to disturbed cholesterol homeostasis which involves the liver, the gallbladder and the intestine on a genetic background. The incidence of cholesterol gallstones is dramatically increasing in parallel with the global epidemic of insulin resistance, type 2 diabetes, expansion of visceral adiposity, obesity, and metabolic syndrome. In this context, gallstones can be largely considered a metabolic dysfunction-associated gallstone disease, a condition prone to specific and systemic preventive measures. In this review we discuss the key pathogenic and clinical aspects of gallstones, as the main clinical consequences of metabolic dysfunction-associated disease.