bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of clinical treatment decisions on long-term survival outcomes of locally advanced breast cancer with different molecular subtypes based on the SEER database
Authors: Qian Fang , Shen Haoyuan , Deng Chunyan , Su Tingting , Chen Anli , Hu Chaohua , Liu Chenghao , Xu Yuanbing , Yang Qingqing , Hu Di , Zhu Jiacheng 
Published: July 2023

Abstract
Background: Some patients with breast cancer are diagnosed with locally advanced breast cancer (LABC). At present, there are no obvious reports on LABC radiotherapy, chemotherapy, and breast-conserving benefit population.
Method: The cases of LABC confirmed by pathology from 2010 to 2015 were searched through the Surveillance Epidemiology and End Results (SEER) database. Breast cancer-specific survival (BCSS) and overall survival (OS) were estimated by plotting Kaplan-Meier curves. The log rank test (Mantel-Cox) was used to analyze the difference between the groups, and the benefit population of LABC was determined after for age, TNM stage, grade, treatment methods.
Results: A total of 34474 LABC patients were included, 22477 (65.2%) were Luminal A, 1418 (4.1%) were Luminal B, 4911 (14.3%) were triple-negative breast cancer, 2461 (7.1%) were HER2-enriched, and 3207 (9.3%) were three positive breast cancer. Kaplan-Meier curves of 5-year OS and BCSS were plotted for LABC patients with different molecular types of breast conserving surgery and mastectomy. Overall the LABC with breast conserving and total mastectomy was 77.8%, 84.6% ,68.4% and 77.2%. Luminal A LABC with breast conserving and total mastectomy was 79.9%,87.5%, 72.3% and 81.5%.Luminal B LABC with breast-conserving and total mastectomy were 79.3% , 83.1%, 70.8% and 77.1%. TNBC LABC with breast-conserving and total mastectomy were 61.0% ,68.4%, 47.5% and 56.2%. HER2-enriched LABC with breast-conserving and total mastectomy were 77.7%, 80.5%, 67.2% and 75.2%. TPBC LABC with breast-conserving and total mastectomy were 84.9%, 91.8%, 75.5% and 82.1%, respectively. Except for the Luminal B LABC BCSS surgery method, there was no significant difference (P=0.058), all the others were statistically significant (P<0.05).
Conclusions: This study found that in the selective population, OS and BCSS of patients with LABC undergoing breast conserving surgery were significantly better than those of mastectomy.This study also found that LABC could be considered for highly differentiated, NO stage TPBC without chemotherapy.
Bonding performance of Chinese fir heartwood and sapwood with different coatings under a high voltage electric field
Authors: He Qian , Hou QianQian , Wang Fangxin , Zhang Daiyuan , Yang Yong , Zhan Tianyi , Yang Dingyi , Li shengcai 
Published: July 2023

Abstract

Inadequate adhesion performance has been observed in the heartwood with high extract content, leading to poor wood durability. To address this issue, we employed a high voltage electric field (HVEF) treatment that combines activation and polarization functions to enhance the bonding strength between wood and the coating layer. The heartwood and sapwood samples were prepared from Chinese fir lumber. Two types of coatings were applied urea formaldehyde (UF) and polydimethylsiloxane (PDMS). The results revealed a higher absorptivity of UF and PDMS on the sapwood compared to the heartwood, attributed to the larger diameter of tracheids and lower extract content, resulting in lower contact angles on the sapwood. Following the HVEF treatment, a reduction in absorptivity was observed for UF on the heartwood, while a decrease in absorptivity was observed for PDMS on the sapwood. This disparity can be attributed to the differential activation and polarization effects of the HVEF treatment on the two types of coatings. The changes in absorptivity were corroborated by the mass gain rate of UF- and PDMS-coated wood samples, with a strong positive correlation observed between the mass gain rate and absorptivity, yielding a correlation coefficient ≥ 79%. The HVEF treatment significantly enhanced the bonding strength of UF-coated heartwood under N-P(-) condition and PDMS-coated sapwood under N-P(+), resulting in the highest increments of 71% and 75%, respectively. Additionally, notable variations in chemical bonds were detected in the FTIR spectrum of UF-coated heartwood under N-P(-), indicating an increased cross-linking extent between the heartwood and UF chemical groups.
Simulation research on dynamic process of dissipative soliton in fiber laser under multi-parameter combination
Authors: Liu Yongli , Liu Pingan , Zhang Zhaohui , Zhu Liguo 
Published: July 2023

Abstract
Positive dispersion ring cavity ultrafast lasers can obtain dissipative soliton output with higher power density. In the process of establishing a stable soliton, it is affected by complex factors such as dispersion, nonlinearity, loss, gain, and key component parameters. Due to the complexity of the parameters involved, the experimental system cannot guarantee the reproduction of the input elements. This means that the experimental research cannot Implement strict variable control. Therefore, establishing a laser simulation model and studying the dynamics of soliton development under complex parameter combinations can help us to understand the feasibility of the scheme conveniently. Through the simulation of complex parameter combinations, it is found that there is a clear optimal working range for obtaining stable mode-locked soliton output, which can be used to guide the design and optimization of laser experiment schemes.
The Relationship between Treatment Suspension Due to the Coronavirus Pandemic and Mental Health of Infertile Patients: A Systematic Review andMeta-Analysis
Authors: Iranifard Elnaz , Yas Atefeh , Ghezelhesari Elahe Mansouri , Taghipour Ali , Mahmoudinia Malihe , Roudsari Robab Latifnejad 
Published: July 2023

Abstract
Background
Access to fertility treatments is considered a reproductive right, but because of the quarantine due to the coronavirus pandemic most infertility treatments were suspended, which might affect the psychological and emotional health of infertile patients. Therefore, this study was conducted to review the relationship between treatment suspension due to the coronavirus pandemic and the mental health of infertile patients.
Methods
This study was conducted based on the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guideline. The ISI, PubMed, Embase, Scopus, and Cochrane library databases were searched by two independent researchers, without time limitation until 31 December 2022. All observational studies regarding the mental health of infertile patients facing treatment suspension including anxiety, depression, and stress were included in the study. Qualitative studies, editorials, brief communications, commentaries, conference papers, guidelines, and studies with no full text were excluded. Quality assessment was carried out using Newcastle-Ottawa Scale by two researchers, independently. The random effects model was used to estimate the pooled prevalence of mental health problems. Meta-regression and subgroup analysis were used to confirm the sources of heterogeneity.
Results
Out of 681 studies, 21 studies with 5901 patients including 5306 female and 504 male infertile patients were systematically reviewed, from which 16 studies were included in the meta-analysis. The results of all pooled studies showed that the prevalence of anxiety, depression, and stress in female patients was 48.4% (95% CI 34.8–62.3), 42% (95% CI 26.7–59.4), and 55% (95% CI 45.4–65), respectively. Additionally, 64.4% (95% CI 50.7–76.1) of patients wished to resume their treatments despite the coronavirus pandemic.
Conclusion
Treatment suspension due to the coronavirus pandemic negatively affected the mental health of infertile patients. It is important to maintain the continuity of fertility care, with special attention paid to mental health of infertile patients, through all the possible measures even during a public health crisis.
Application of cattle manure increased the stability of organic carbon in the subsoil in Mollisols
Authors: Zhang Qilin , Zhou Daowei , Hu Juan 
Published: July 2023

Abstract

Aims: The cattle manure application to subsoil is an efficient and sustainable approach to increase soil fertility. However, the change of soil organic carbon (SOC) chemistry after manure amended in subsoil is remains elusive.
Methods: Here, a pot experiment was used to investigated the SOC chemical structure (13C-NMR and FTIR), as well as microbial community composition (PLFA), with cattle manure amended in topsoil (T1M), and subsoil (T2M) and without manure in topsoil (T1) and subsoil (T2).
Results: The utilization of cattle manure significantly improved SOC, total nitrogen (TN) content and PLFAs biomass, as well as the relative absorption of the band at 2920 cm-1 and 1640 cm-1 of SOC, while decreased the C/N ratio by 15.7-50.5%. T1M increased the proporations of O-alkyl C and Aromatic C by 3.8%-17.6% compared to T1, but decreased the proporations of Alkyl C and Carbonyl C by 9.9%-11.5% and the ratio of Alkyl C/O-Alkyl C (A/OA) by 60.0%. However, T2M showed the opposited trend compared to T2. The fungal to bacterial ratio (F/B) of T2 was lower than that of T1, while it was greater in T2M than that in T1M. Both RDA and MRT analyses demonstrated that the Cyanobacteria, Acidobacteria and Ascomycota were negatively association with O-alkyl C, and the Actinobacteria, Verrucomicrobia and Cyanobacteria were negatively association with Alkyl C.
Conclusions: Our findings reveal application cattle manure in subsoil was more beneficial to decompose SOC owing the transfromation of bacterial to fungal and made the chemical structure of SOC more stabilization.
Study on wear mechanism of milling cutter and hole-making quality in ball helical milling process
Authors: Wang Haiyan , Lu Yao , Tian Gan 
Published: July 2023

Abstract

In order to deeply understand the wear mechanism of the ball end mill in helical milling process, the TiAlN coated carbide ball end mill is used for the machining of titanium alloy under dry cutting conditions, focusing the influence of tool wear on the cutting process and hole-making quality. Firstly, the geometry of the ball end mill and material removal process during the helical milling process are discussed. Secondly, based on the different zone, tool microscope, electron microscope and energy spectrum were used to detect the tool wear, so as to clarify the tool wear mechanism, and then explore the relationship between axial cutting force, radial cutting force, cutting temperature and tool wear, the influence of the tool wear degree on the cutting process is analyzed. Finally, the changes of hole-making quality with different tool wear degrees are studied from the perspectives of geometry, machining defects and exit burr of the hole-making, respectively. The results show that in order to get better hole-making quality, the magnitude of cutting force and cutting temperature should be controlled to increase the tool life in the normal wear stage.
The role of oxidative burst and cell wall in tomato interaction with various taxonomic groups of Rhizoctonia spp
Authors: Taheri Parissa , Hosseini-Zahani Fatemeh , Tarighi Saeed 
Published: July 2023

Abstract
In this research, interaction of multinucleate Rhizoctonia solani and a binucleate isolate of Rhizoctonia sp. (BNR) was investigated with using tomato as a susceptible host. The highest levels of O2−, H2O2, callose accumulation and superoxide dismutase activity were observed for the isolate of R. solani AG 3, which caused lower disease severity compared to highly pathogenic R. solani isolates belonging to AG 4 HG-I and AG 4 HG-II. Xanthine/xanthine oxidase treatment, which induced O2− production, increased the disease symptoms. Whereas, glucose/glucose oxidase, which increased H2O2, decreased the disease symptoms. Ascorbate, as an inhibitor of H2O2 accumulation, reduced callose deposition and increased the disease severity. Analyzing activity of cell wall degrading enzymes (pectinase and cellulase) produced by different fungi showed higher activity of these enzymes for the isolates with higher pathogenicity. Therefore, defense components of host plant and pathogenicity factors of fungi are both involved in the outcome of plant-fungi interaction.
The analysis of the long-term trend of extreme precipitation and discharge in Burundi
Authors: Gatore Ayse Claire Ignaline , Kim Seon-Ho , Bae Deg-Hyo , Islam Md Feroz , Parisouj Peiman 
Published: July 2023

Abstract
Climate change has become an undeniable global challenge which emphasizes the necessity for a deeper understanding of historical and future climatic trends. This study offers a comprehensive analysis to the reality of the extreme events and their impact in Burundi. This research estimates the annual mean, seasonal and monthly along with six extreme indices for precipitation and four for discharge based on observed dataset of over 30 years. Statistical methods were therefore used: the linear regression, the Mann Kendall test; and the Moran’s I test assessed the spatial correlation. The findings reveal a decreasing annual trend in rainfall particularly in the East with a correlation coefficient of 0.228. Suprisingly, the seasonal pattern did not show consistency in rainy seasons, December and January exhibited significantly positif trends. However, all extreme indices except for the MDRY (0.341) and PX1D (0.411) exhibited low Moran's I values. Regarding discharge, shared yet distinct trends in both the annual mean, the seasonal and monthly variables where observed. The Gisuru station displayed a negatif trend while Mutambara station showed positif trend. Notably, both basins exhibited significant seasonal trends during the FMAM season. For the extreme indices, similar patterns were found except in MAXY and DWF and MAXYF indices. The information in this study contributes to the growing body of knowledge of the impacts of climate change in Burundi and demonstrates the urgency for proactive measures to mitigate and ensure long term resilience and sustainability of this region.
Monolayer and bilayer BP as efficeiant optoelectronic materials in visible and ultraviolet regions
Authors: Behzad Somayeh , Chegel Raad 
Published: July 2023

Abstract
Utilizing first-principles calculations, the effects of interlayer interaction and biaxial strain on the phonon dispersion and optical properties of BP sheet are investigated. The calculated phonon spectra shows that the monolayer and bilayer structures are dynamically stable. The phonon bandgap of monolayer BP decreases under tensile strain and increases under the compressive strain. The LO and TO modes harden under compressive strain and soften under tensile strain. The interlayer coupling in bilayer BP causes the splitting of out-of-plane ZA and ZO modes at the Γ point and the phonon band gap decreases with increasing the tensile strain. The absorption edge of bilayer BP is located around 0.6 eV, and it is at a lower energy with respect to the monolayer BP. The results indicate that the optical absorption may be enhanced by applying the compressive strain. These results demonstrate that the phonon dispersion and optical properties of BP sheet could as well be tuned with both interlayer interaction and biaxial strain that are promising for optoelectronic and thermoelectric applications.
Research on the infection status of and factors influencing COVID- 19 based on a questionnaire survey
Authors: Zengfeng SU , 翟 羽佳 , 崔 璨 
Published: July 2023

Abstract
Purpose
To investigate the infection situation of coronavirus disease 2019 (COVID-19) in the population after the lifting of epidemic prevention and control measures and to study and analyze its related influencing factors.
Methods
From March 11 to March 20, 2023, questionnaires on COVID-19 infection were distributed on the Questionnaire Star platform, and SPSS 19.0 software was used for statistical processing.
Results
The results showed that the infection rate of COVID-19 among the respondents reached 72.24%. Fever, fatigue, cough were the main symptoms during infection, among which 58.81% of infected people reported post COVID-19 symptoms. An unconditional logistic regression model showed that age (P = 0.002), area of residence (P༜0.001), vaccine doses (P = 0.025) were statistically significant.The infection risk was the lowest (OR = 0.40; 95% CI = 0.14–1.11) in the ≤ 17 age group and the highest (OR = 1.40; 95% CI = 0.63–3.10) in the 18–44 age group.The risk of infection was higher in urban areas (OR = 2.28; 95% CI = 1.69 ~ 3.35). The risk of infection among one dose of vaccine was the highest (OR = 1.77; 95% CI = 0.43 ~ 7.28).
Conclusions
COVID-19 had a high infection rate, children had a lower risk of COVID-19.People who lived in cities were more susceptible to COVID-19 and it is necessary to increase the number of vaccine doses.
TCDD and kynurenine induce Parkin expression in SH-SY5Y neuroblastoma cells through different signaling pathways mediated by the aryl hydrocarbon receptor
Authors: Murillo-González F. E. , García-Aguilar M. R. , Limón-Pacheco J. , Cabañas-Cortés M. , Elizondo G 
Published: July 2023

Abstract
Parkin plays an important role in regulating protein degradation and mitophagy in dopaminergic neurons. Deficiencies in Parkin expression or function result in cellular stress, degeneration, and eventual death of dopaminergic neurons, contributing to the development of Parkinson's disease. Conversely, overexpression of Parkin enhances neuronal survival. Therefore, understanding the mechanisms of Parkin regulation is gaining importance. In this study, we described, for the first time, the molecular mechanism by which the aryl hydrocarbon receptor (AHR) mediates the upregulation of Parkin in human SH-SY5Y neuroblastoma cells.
Specifically, we demonstrate that the human Parkin gene (PRKN) is transcriptionally upregulated by AHR through two distinct pathways depending on the nature of the AHR ligand. The stress-inducing AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) indirectly promotes Parkin transcription by inducing the expression of activating transcription factor 4 (ATF4). This mechanism involves TCDD-mediated endoplasmic reticulum (ER) stress. On the other hand, kynurenine, a nontoxic AHR agonist, induces Parkin transcription by promoting AHR binding to the PRKN gene promoter without activating ER stress.
Our findings demonstrate that AHR activation represents a potential pharmacological pathway to induce human Parkin. However, attention must be exercised regarding the nature of the AHR ligand to mitigate potential neurotoxic side effects.
From Classroom Learning to Clinical Practicum: Qualitative and Quantitative Evaluation of Undergraduate Students’ Learning in Adult Nursing
Authors: Chen Li-Chin , Lin Chun-Chih , Han Chin- Yen , Huang Ya-Ling 
Published: July 2023

Abstract
Background: Because the nursing field is both theoretical and practical, it is crucial that the connection between the two is reflected in the curriculum.
Objective: This study investigated educators’ perspectives on the contribution of Adult Nursing classrooms to clinical learning.
Methods: Data were gathered from 153 retrospective records of undergraduate nursing students, 32 clinical facilitator feedback reports on students' practicum, and 12 in-depth interviews. The study was conducted in Taiwan between February and September 2019. Quantitative results were analyzed using appropriate descriptive and inferential statistics, while qualitative data were analyzed using content analysis following the COREQ guidelines.
Results: Research findings indicate a positive relationship between classroom learning and practical application in Adult Nursing. Specifically, the study revealed that theoretical (β=.246; t=3.03; p <.005) and laboratory (β=.201; t=2.25; p = .014) components of Adult Nursing are strong predictors of success in the practicum. This highlights the importance of gaining theoretical knowledge and clinical experience.
The teaching and learning experience in the Adult Nursing practicum can be categorized into three stages: struggling to adapt, improving care abilities, and revising guidance plans. There were several phases throughout the internship, including orientation, assessment, implementation, evaluation, and independent work, which lasted several weeks.
Conclusion: The quantitative results indicated that the scoring system was consistent and reliable. The predictors highlight the accumulation of theoretical knowledge, laboratory skills, and clinical experience. Students struggled to adapt to the Adult Nursing practicum due to the unfamiliar work environment and care roles. Positive feedback from clinical instructors encouraged and motivated students to improve their clinical performance, which enabled them to work independently in the third week. The results offer valuable insights into the facilitators’ perspectives on students' clinical learning. The study found a positive correlation between academic performance and practical application, contributing to the overall organization of the Adult Nursing course.
Tree-Invent: A novel molecular generative model constrained with topological tree
Authors: Xu Mingyuan , Chen Hongming 
Published: July 2023

Abstract
De novo molecular design plays an important role in drug discovery. Here a novel generative model, Tree-Invent, was proposed to integrate topological constraints in the generation of molecular graph. In this model, a molecular graph is represented as a topological tree in which ring system, non-ring atom and chemical bond are regarded as ring node, single node and edge respectively. The molecule generation is driven by three independent sub-models for carrying out operations of node addition, ring generation and node connection. One unique feature of the generative model is that topological tree structure can be specified as constraint for structure generation, which provides more precise control on structure generation. Additionally, the quality of ring structure is also improved by reducing the occurrence of macrocycle during structure generation. Combining with reinforcement learning, Tree-Invent model could efficiently explore targeted chemical space. Moreover, Tree-Invent model is flexible enough to be used in versatile molecule design settings such as scaffold decoration, scaffold hopping and linker generation.
Quantifying the health impact of PM 2.5 using the AirQ model in the metropolitan Isfahan, Iran, in 2018-2019
Authors: Leili Mostafa , Asl Farshad Bahrami , Dehdar Ali , Jamshidi Reza 
Published: July 2023

Abstract
Purpose
The Middle East Dust Storms (MEDS) phenomenon has been causing issues in many Iranian cities including Isfahan, as a result, the air quality in those cities has deteriorated over the recent years. The purpose of this study is to quantify the health impacts of PM2.5 on human health by applying the AirQ model approach in the metropolis of Isfahan during 2017–2018.
Methods
This study used AirQ 2.2.3 model software to evaluate the human health effects of PM2.5 for residents of Isfahan.
Results
The average annual concentration of PM2.5 was 31 µg/m3 and 26 µg/m3 during 2018 and 2019 years. The attributable proportion (AP) of total mortality attributable to PM2.5 was predicted to be 3.11% and 2.37% (95% confidence interval (CI)) of the total mortality, and the cases of excessive deaths were estimated to be 339.7 and 264.4 persons, respectively. These estimates were based on the resolved baseline incidence (BI) and relative risk (RR) rate.
Conclusion
This study offers extra information for decision-making in the formulation of plans to diminish indoor air pollution, which will enhance the quality of the air.