bluuebunny/crossref_metadata_2025_split huggingface dataset:
An observational study on dapagliflozin as an add-on therapy in type-2 diabetes mellitus patients in a tertiary care teaching hospital
Authors: Reddy M. Venugopal , Sahayaraj Christina , Haseena Begum Shaik , Sonia S. Sharon , Reddy Y. Vijayabhaskar 
Published: February 2023

Background: Diabetes mellitus is one of the prevalent morbid conditions all over the world and no exception for India. Day by day, increase in its prevalence is attributed to lifestyle derangements. To treat this condition many drugs and treatment modalities are developed. Dapagliflozin is an oral antidiabetic drug which acts by sodium-glucose cotransport-2 (SGLT-2) inhibition. Its effectiveness seen in type-2 diabetes mellitus makes it an option for Add-On therapy.
Methods: This study is a retrospective observational study conducted at tertiary care hospital, GGH, Kurnool. The study proposal has been reviewed and approved by institutional ethics committee. All adult diabetic patients who were prescribed Dapagliflozin during the period of January 2021 to February 2022, total 45 were included in the study. FBG, HbA1c collected through hospital records from General Medicine and Endocrinology. Patients who stopped drug before 3 months period were excluded.
Results: Administration of dapagliflozin as an add-on therapy was found 26.63% decrease in base line mean FBG 184 mg/dl to 135 mg/dl after 3mnoths which is significant (p=0.001). Mean HbA1c significantly reduced by 0.96 percentage point after 3 months (p=0.001). Dapagliflozin effectively reduced the FBG and HbA1c when used in combination with other OHAs or insulin within 3 months.
Conclusions: Dapagliflozin as an add-on therapy significantly reduced the HbA1c level and fasting blood glucose of Type-2DM patients, in a 3-month treatment period. Due to the frequency of Genitourinary tract infections, caution is indicated while treating the patients.
Estudo da Transformada Wavelet Contínua para análise de sinais EEG normais e ictais
Authors: Silva Thiago Bastos da , Campos Sílvia Mara da Costa 
Published: February 2023

Neste artigo propomos o uso da transformada wavelet continua para analisar alguns sinais específicos obtidos via eletroencelalograma (EEG). O EEG é um exame muito utilizado para análise da atividade elétrica cerebral e, através dele, é possível detectar, em determinadas bandas de frequência, se essa atividade elétrica está de acordo com as normas estabelecidas. Para atingir este objetivo, primeiramente explicaremos um pouco sobre o funcionamento do EEG e depois utilizaremos a transformada wavelet contínua, por meio de um programa escrito na linguagem python, para analisar o comportamento de sinais de EEG nos domínios do tempo e da frequência. São dois tipos específicos de sinais estudados: de pessoas saudáveis e de pessoas em crise epiléptica, conhecidos como sinais ictais. Foram utilizados sinais de uma base de dados consolidada da Universidade de Bonn. Os principais resultados foram a obtenção dos dados estatísticos obtidos dos sinais e de seus respectivos escalogramas, em que foram comparados a diferença entre os valores máximos, média de valores e outros parâmetros de cada sinal e escalograma.
Modelación de errores de concordancia plural en español LE mediante sistemas dinámicos
Authors: Marafioti Pablo Ezequiel 
Published: February 2023

Propósito: Se modelan los errores de concordancias nominales plurales para un corpus de español de cuatro aprendientes de español como lengua extranjera: SONIA (nivel A1/A2), NATI (nivel B1), JAKO (nivel B2), MIRKA (nivel C1). Metodología: En el marco de los sistemas dinámicos, se postula que las concordancias “correcta” e “incorrecta” constituyen atractores discretos estables a los cuales converge el flujo continuo del sistema en tres modelos simples de simulación: Lokta-Volterra, juego de coordinación (teoría de los juegos evolutiva), ascenso de gradiente. Resultados: En general los modelos aproximan mejor el patrón de error global que el de sesiones. En este último, el modelo basado en Lokta-Volterra ofrece mejor desempeño para SONIA, NATI y JAKO. MIRKA obtiene el peor desempeño en todos los modelos pero su error disminuye con el modelo de ascenso de gradiente. Conclusión: los patrones de aprendizaje se auto-organizan y emergen de la dinámica de micro-sistemas de concordancia.
Filosofía Intercultural y Nuestra Améfrica Profunda
Authors: Mendes de Menezes Magali 
Published: February 2023

O presente texto pretende refletir sobre a interculturalidade e sua necesidade histórica, através de dois autores centrais, Raúl Fornet-Betancourt e LéliaGonzalez. O conhecimento dos porvos indígenas e negros foi apagado e nem sequer reconhecido como conhecimento filosófico. Qusndo se reconhece a filosofia amerindia, se faz em comparação com a filosofia ocidental e com tudo que esta produziu. Neste sentido, la Filosofia Intercultural coloca o desafio de repensar la filosofia desde outras experiências de pensamento. O epistemicidio expõe o racismo em que vivimos. O encontro do filósofo cubano com a filósofa brasileira, uma mulher negra, dará força a uma categoria de pensamento que pretendo desenvolver, Améfrica Profunda, para melhor compreender este país chamado Brasil e a forma em que as resistências dos povos indígenas e negros se constituiram, también a partir de profundas experiencias interculturais.
PERAN KELUARGA PADA PENATALAKSANAAN JENAZAH COVID 19 DALAM PERSPEKTIF PERUBAHAN SOSIAL (KAJIAN SOSIOLOGI HUKUM)
Authors: Emi La Ode 
Published: February 2023

<p><span lang="EN-US">Pandemi covid-19 yang terus meluas sejak tahun 2020 ini menyebabkan Kepanikan masyarakat yang berlebihan terhadap pandemi global ini, dikeluarkannya Keppres No. 12 Tahun 2020 tentang penetapan bencana non alam penyebaran Corona Covid disease 2019. Kemudian berdasarkan Pasal 152 Undang-Undang No. 36 tahun 2009 tentang kesehatan menyatakan bahwa Pemerintah, pemerintah daerah dan masyarakat bertanggung jawab melakukan upaya pencegahan, pengendalian, dan pemberantasan penyakit menular serta akibat yang ditimbulkannya, dengan demikian dikarenakan covid-19 termasuk penyakit yang proses penularnnya cepat maka dalam upaya pemerintah melakukan pengendalian dan pemberantaran covid-19. Munculnya berbagai persepsi di masyarakat terkait dengan protokol penangangan jenazah Covid-19 membuat terjadinya penolakan pemakaman jenazah tersebut di area pemakaman yang dekat dengan permukiman penduduk. Persepsi masyarakat adalah pada proses jenazah tidak dimandikan dan langsung dikafani bagi yang beragama Islam. Penelitian ini bertujuan untuk membahas peran keluarga dalam penatalaksanaan jenazah covid 19 agar tidak terjadi lagi penolakan di dalam masyarakat. Penelitian menggunakan metode penelitian normatif. Efektif atau tidaknya usaha pemerintah dalam penatalaksanaan Jenazah Covid 19 berkorelasi dengan faktor-faktor di atas dan ketegasan dari para pemimpin serta kesadaran masyarakat. Roscoe Pound menyatakan bahwa hukum yang sebenarnya adalah hukum yang dijalankan. Hukum bukan hanya yang tertulis dalam undang-undang, melainkan apa yang dilakukan oleh aparat penyelenggara hukum dan atau siapa saja yang melaksanakan fungsi pelaksanaan hukum dengan konsep hukumnya, yaitu hukum dapat berperan sebagai sarana perubahan masyarakat (law as a tool of social engineering).</span></p><p> </p>
KOMPARASI PENDEKATAN RESTORATIVE JUSTICE DALAM PENANGANAN PERKARA PIDANA ANTARA KEPOLISIAN DAN KEJAKSAAN
Authors: Rante Ubleeuw Agustinus Gabriel 
Published: February 2023

<p>Tujuan dari penelitian ini adalah untuk mengetahui perbedaan dan persamaan antara kewenangan lembaga kepolisian dan lembaga Kejaksaan dalam menangani perkara pidana dengan pendekatan restorative Justice. Dewasa ini memang kedua lembaga tersebut memiliki kewenangan yang sama dalam restorative justice tetapi metode yang digunakan berbeda karena mereka memiliki payung hukum masing-masing dalam menerapkan pendekatan restorative Justice. Sedangkan metode yang digunakan dalam penelitian ini yaitu menggunakan metode yuridis normatif di mana peraturan Kepolisian Republik Indonesia dikomparasi dengan peraturan kejaksaan Republik Indonesia untuk menemukan titik temu perbedaan dan persamaan penanganan perkara pidan dengan pendekatan restorative justice. Ruang lingkup dalam penelitian ini yaitu dalam wilayah yuridis penegakan hukum lembaga kepolisian dan ruang lingkup yuridis penegak hukum lembaga kejaksaan. Hasil dari penelitian ini memiliki persamaan dan perbedaan mulai dari persamaan kewenangan dalam pendekatan perkara pidana dengan menggunakan restorative Justice, tetapi mereka memiliki perbedaan dalam hal penyelidikan dan penyidikan. Sedangkan lembaga Kejaksaan memiliki kewenangan untuk melakukan penuntutan. Kesimpulan yang dapat diambil dari penelitian ini yaitu perbandingan antara persamaan dan perbedaan penanganan perkara pidana di kepolisian dan Kejaksaan dengan pendekatan restorative Justice. Kedua lembaga memiliki kewenangan yang sama dalam restorative justice sehingga seringkali terjadi tumpang tindih dalam melakukan penegakan hukum karena kedudukan atau payung hukum yang mereka miliki memiliki kedudukan yang sama secara hierarki, Oleh sebab itu perlunya dilakukan perubahan hukum untuk menyesuaikan dengan keadaan di masyarakat.</p><p> </p>
PROBLEMATIKA HUKUM PEER TO PEER LENDING SYARIAH DI INDONESIA
Authors: Mukminati Andan Hafsari 
Published: February 2023

<p align="justify">Ekonomi syariah dan industri <em>financial technology</em> (<em>fintech</em>) di Indonesia mengalami pertumbuhan pesat. <em>Fintech</em> berperan penting dalam industri keuangan islam, seperti perbankan, pasar modal, dan Industri Keuangan Non-Bank. Salah satu fintech syariah yang tumbuh di Indonesia adalah <em>peer to peer lending</em> (pinjaman online) syariah. Namun, industri <em>fintech</em> syariah di Indonesia masih menghadapi tantangan dan problematika hukum. Hal ini tampak pada <em>market size</em> fintech syariah Indonesia yang masih berada di bawah Arab Saudi, Iran, UAE dan Malaysia. Berkaitan dengan latar belakang tersebut, diperlukan penelitian lebih lanjut mengenai problematika hukum P2P Lending Syariah di Indonesia. Jenis penelitian ini adalah penelitian hukum, Metode pendekatan yang digunakan adalah pendekatan perundang-undangan <em>statute approach</em>. <em> </em>Bahan hukum yang digunakan adalah bahan hukum primer dan bahan hukum sekunder yang terkait dengan P2P <em>Lending syariah</em> dan ekonomi digital. Teknik pengumpulan data dilakukan dengan studi pustaka. Hasil penelitian ditemukan bahwa P2P <em>Lending syariah </em>di Indonesia masih menghadapi berbagai problematika hukum, diantaranya: peraturan perundang-undangan yang belum memadai, kepatuhan syariah yang masih lemah, dan isu penyalahgunaan <em>fintech</em> syariah<em> </em>untuk pendanaan terorisme. </p>
Femoral-Sided Avulsion Fracture of the Anterior Cruciate Ligament in a Skeletally Immature Patient
Authors: Czer Eric , Menzer Heather , Vij Neeraj , Metzger Charles 
Published: February 2023

Case:
A 10-year-old boy presented to the clinic with sharp left knee pain after sustaining an injury while hiking. The patient was unable to bear weight. Physical examination demonstrated a moderate effusion and lateral joint line tenderness. Imaging studies revealed a femoral-sided avulsion of the anterior cruciate ligament. Arthroscopic suture fixation of the avulsed fragment resulted in good radiographic and clinical results at the 13-month follow-up.

Conclusion:
Physeal-sparing suture-fixation of femoral-sided anterior cruciate ligament avulsion injuries can be performed using an all-arthroscopic approach and may be a viable treatment option.
Osseous Ilio-Trochanteric Bars as an Etiology of Hip Contracture in a Child with Congenital Contractures
Authors: Cetik Riza Mert , Aksoy Taha , Yilmaz Guney 
Published: February 2023

Case:
A 5-month-old female patient presented with bilateral lower-limb deformities. Hips were fixed at 100° abduction, 15° flexion and 45° external rotation, flexion contracture in the knees, and bilateral teratologic equinovarus deformities. Radiographs revealed ilio-trochanteric osseous bars as the etiology of hip contractures. Staged surgeries were undertaken. At 4 years of age, she could stand upright with orthoses and sit without support.

Conclusion:
This is the first study to report bilateral congenital ilio-trochanteric osseous bars, which were resected without recurrence. Even with a very low potential of walking, release of the contractures allows for better function and possible wheelchair-dependent mobility in the future.
Resolution of Psoriatic Plaques of the Leg After Nailing of an Ipsilateral Tibial Shaft Fracture
Authors: Esper Garrett W. , Meltzer-Bruhn Ariana T. , Furgiuele David L. , Scher Jose U. , Egol Kenneth A. 
Published: February 2023

Case:
This case describes a 45-year-old man with documented history of untreated bilateral lower extremity psoriasis of equal severity who sustained a closed left tibial-fibular shaft fracture. After operative fixation with an intramedullary nail under a regional nerve block, the left lower extremity circumferential psoriatic plaque resolved throughout 1 year of follow-up with persistence of the contralateral limb disease.

Conclusion:
This case describes a rare outcome for a patient with bilateral leg psoriasis who experienced resolution of psoriatic plaques on the operated leg only after surgery. It is unknown which process: injury, anesthetic, surgery, or fracture healing mediated this unique finding.
Iatrogenic Vertebral Fracture During Intramedullary Nailing for Femoral Fracture
Authors: Joo Yong-Bum , Lee Woo-Yong , Kim Young- Mo , Ahn Byung-Kuk 
Published: February 2023

Case:
A 73-year-old woman with advanced ankylosing spondylitis (AS) underwent closed reduction and internal fixation using antegrade intramedullary nailing because of midshaft fracture of her right femur. After the surgery had been performed, a fracture and dislocation at T12–L1 was detected. Therefore, emergency spinal decompression and posterior instrumentation placement from T11 to L5 were then performed.

Conclusion:
Patients with advanced AS have a high risk of vertebral fracture, so special care must be taken not to transmit excessive stress on the spine for surgical reduction and manipulation of the lower extremity.
Fungal Arthritis of a Lumbar Facet Joint Because of Candida albicans
Authors: Tanabe Tsuyoshi , Takasaki Minoru , Kaneumi Kousuke , Hara Masamitsu 
Published: February 2023

Case:
A 73-year-old man who was treated in our hospital for pyelonephritis because of left ureteral stones and fungemia was referred to our orthopaedic department for persistent right lower-back pain. Magnetic resonance imaging and computed tomography findings showed pyogenic arthritis of the right L4/5 facet joint with a paraspinal muscle abscess. Based on cultures of samples aspirated from the lesions, we diagnosed the patient with fungal arthritis of the lumbar facet joint. We treated him conservatively with an antifungal agent for a year, and the infection resolved.

Conclusion:
This is the first report of hematogenous fungal arthritis of a lumbar facet joint.
RSA Measurements of Implant Instability in a Paprosky III Pelvic Defect with Discontinuity
Authors: Ramasamy Boopalan , Abrahams John Matthew , Clothier Robyn Janice , Solomon Lucian Bogdan , Callary Stuart Adam 
Published: February 2023

Case:
We report a case of acetabular reconstruction for a large defect with pelvic discontinuity that underwent 4 revisions for dislocations over a 3-year period. This allowed assessment of implant stability both on imaging, using measurements on plain radiographs and radiostereometric analysis (RSA) against both ilium and ischium, and direct assessment during each surgery. Only implant stability measured with RSA correlated with intraoperative revision findings.

Conclusion:
This case underlines the role of RSA in assessing early acetabular implant stability in pelvic discontinuity and the importance of assessing the stability of the implant against both ilium and ischium.
Surgical Treatment of Chondrodysplasia Punctata Tibial-Metacarpal Type Until Skeletal Maturity
Authors: Fujimoto Yoh , Takikawa Kazuharu , Takeshita Yujiro 
Published: February 2023

Case:
An infant boy with chondrodysplasia punctata tibial-metacarpal type (CDP-TM) was followed up till skeletal maturity. The patient underwent surgeries for bilateral patellar dislocations at the age of 9 years of age, left leg length discrepancy at 12 years, and atlantoaxial subluxation at 14 years. At the final follow-up at 18 years, he had no complaints or limitation of his daily life activities.

Conclusion:
CDP-TM may require multiple orthopedic surgeries such as patellofemoral instability, limb length discrepancy, and upper cervical dysplasia until skeletal maturity, and should be followed in order to identify them early.
Transient Exertional Compressive Radial Neuropathy in a Collegiate Baseball Pitcher
Authors: Wellington Ian J. , Garvin Patrick M. , Stelzer John W. , Morgan Courtney , Alessi Anthony , Hall Matthew , Rodner Craig , Edgar Cory 
Published: February 2023

Case:
A 21-year-old collegiate baseball pitcher presented with transient lateral arm pain and wrist extension weakness after pitching more than 1 inning. Physical examination was unremarkable at rest. Ultrasound-guided injection of the radial nerve at the level of the lateral intramuscular septum improved his symptoms. After decompression of the radial nerve, the patient noted resolution of his symptoms while pitching.

Conclusion:
Atraumatic radial neuropathy is a rare but documented phenomenon. As far as we know, this is the first reported case of a transient exertional radial neuropathy in an athlete at the level of the lateral intermuscular septum.
Median Nerve Compression in the Distal Forearm by a Reversed Palmaris Longus Muscle in a Pediatric Patient
Authors: Moreira Flávia Pinto , Ferreira Filomena , Vieira Luis , Negrão Pedro 
Published: February 2023

Case:
A 9-year-old girl presented with a 1-year history of volar wrist and hand pain accompanied by hand paresthesia. Magnetic resonance imaging described a superficial muscle belly in the distal forearm, compatible with a reversed palmaris longus (RPL). An initial trial of conservative treatment was unsuccessful, so the median nerve was explored in the distal forearm, with the release of the flexor retinaculum and resection of the RPL muscle belly. One year after surgery, the child had no symptoms.

Conclusion:
To the best of our knowledge, there are only 12 reported cases of RPL, and none at such a young age or symptomatic in daily routine activities such as the case presented.
Obsequies of My Lady Mary (II): A Fragmentary Syriac Palimpsest Manuscript from Deir al-Suryan (BL, Add 14.665, no. 2)
Authors: Kessler Christa 
Published: February 2023

This Syriac palimpsest manuscript with four remaining folios bound with others into one volume runs under the shelf mark Add 14.665, no. 2 in the British Library. It displays a well-executed 5th century Estrangela. William Wright in his Contributions to the Apocryphal Literature of 1865 offered only readings of some scanty passages. The text has been neglected ever since. Preserved in it are sections of an early witness for the Obsequies of My Lady Mary in Syriac (S1) covering the final part of the second book, the beginning of book three, and central sections of book five with the apocryphal History of Peter and Paul according to the Ethiopic five-book cycle. The textual diversity is at times considerable in comparison to the other early transmissions in Greek and Christian Palestinian Aramaic, and the much later Ethiopic one. It has been the first Syriac source to attest the central term for the palm tradition ܬܘܠܣܐ ‘palm-shoot’. The new and additional readings intend to fill some lacunae in the only partially preserved transmission of the early Syriac translation of the Dormition of Mary from Upper Mesopotamia.
Device-to-Device (D2D) Discovery Simulator for 3GPP and Public Safety Network (PSN)
Authors: Marttin Vedat , Yüzgeç Uğur , Bayılmış Cüneyt , Küçük Kerem 
Published: February 2023

Abstract

The Public Safety Network (PSN) is important for providing communication after a possible disaster. It provides a communication opportunity between the victims under the wreckage and the rescue team in the case of base stations do not function. Device-to-device (D2D) discovery and communication provides communication services in such difficult situations without the requirement of network infrastructure and by reducing call traffic in cellular communication networks. Therefore, device discovery according to different parameter values in the simulator environment for 3GPP and PSN provides great convenience to users in the application phase. In this study, we presented a device-to-device (D2D) discovery simulator based on the Matlab Graphical User Interface (GUI) for the students and researchers related to the wireless communication area. In this simulator, there are different pathloss models for D2D communication along with the parameters suggested by 3GPP and PSN for educational and research purposes. D2D discovery results are given in visual graphics with the parameter settings in the simulator’s interface. Thanks to the D2D discovery simulator, the students and researchers can easily understand how the user mobile devices discover each other which is necessary for D2D communication in the disaster area. They can also compare device discovery algorithms with different parameters and models. Six different scenario examples and an evaluation questionnaire about the D2D discovery simulator were proposed to students and researchers at a University in Turkey. The users (students and researchers) can easily test D2D discovery algorithms with different simulation parameters with a user-friendly interface thanks to the developed simulator.
Mechanism of MEK1-MAPK Pathway-based MiR520a-5p in Fetal Growth Restriction
Authors: Xiang Meng , Jha Rajiv Kumar 
Published: February 2023

Abstractthis research was developed to investigate the expression level of miR520a-5p in serum of fetal growth restriction (FGR) and the role of its target genes, mitogen-activated protein kinase (MAPK) and mitogen-activated protein kinase 1 (MEK1), in the pathogenesis of FGR. Thirty cases in the FGR group and 30 cases in the normal birth weight group (control group) were selected. MiR520a-5p expression and its target genes MEK1 and MAPK mRNA in the two groups were detected by RT‒PCR. The protein levels of the target genes MEK1 and MAPK of miR520a-5p were determined by Western blotting. The Spearman grade correlation was used to analyze the correlation between the expression levels of miR520a-5p and MEK1 in serum of FGR group and the correlation between MEK1 and MAPK expression. Compared with the control group, the expression of miR520a-5p in the FGR group was significantly increased (P < 0.05). MEK1 and MAPK mRNA levels of miR520a-5p target genes in the FGR group were drastically reduced (P < 0.05), while their protein levels were decreased (P < 0.05). Spearman rank correlation analysis suggested a negative correlation between miR-520a-5p and MEK1 (r = − 0.667;P < 0.05) and a positive correlation between MEK1 and MAPK (r = 0.46;P < 0.05). MEK1 and MAPK mRNA expressions in fetal growth and development were detected, and the decreased expression of MEK1 and MAPK mRNA was correlated with the pathogenesis of FGR. MiR520a-5p may participate in the pathogenesis of FGR through the MIRR520A-5P-MEK1-MAPK signaling pathway.