bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating patient voices into the extraction of social determinants of health from clinical notes: ethical considerations and recommendations
Authors: Hartzler Andrea L , Xie Serena Jinchen , Wedgeworth Patrick , Spice Carolin , Lybarger Kevin , Wood Brian R , Duber Herbert C , Hsieh Gary , Singh Angad P ,   SDoH Community Champion Advisory Board, Cragg Kase , Goomansingh Shoma , Simons Searetha , Wong J J , Yancey-Watson Angeilea’ 
Published: March 2023

Abstract
Identifying patients’ social needs is a first critical step to address social determinants of health (SDoH)—the conditions in which people live, learn, work, and play that affect health. Addressing SDoH can improve health outcomes, population health, and health equity. Emerging SDoH reporting requirements call for health systems to implement efficient ways to identify and act on patients’ social needs. Automatic extraction of SDoH from clinical notes within the electronic health record through natural language processing offers a promising approach. However, such automated SDoH systems could have unintended consequences for patients, related to stigma, privacy, confidentiality, and mistrust. Using Floridi et al’s “AI4People” framework, we describe ethical considerations for system design and implementation that call attention to patient autonomy, beneficence, nonmaleficence, justice, and explicability. Based on our engagement of clinical and community champions in health equity work at University of Washington Medicine, we offer recommendations for integrating patient voices and needs into automated SDoH systems.
Delayed Tracheoesophageal Fistula and Refractory Respiratory Failure Caused by Inhalation Burns and Emergency Venovenous ECMO to Facilitate Its Management: A Case Report
Authors: Dhanani Jayesh , Pincus Jason , Townsend Shane , Pang George , Vujcich Elizabeth , Windsor Morgan , Reade Michael C 
Published: March 2023

Abstract
Acquired tracheoesophageal fistulae are uncommon in burn patients but can occur as a complication of inhalation injury. We report a case of a 30-yr-old male patient presenting after suffering from inhalation and 25% total body surface area burns. On postburns day 14, he developed a massive tracheoesophageal fistula causing refractory acute respiratory failure. Veno-venous extracorporeal membrane (VV ECMO) oxygenation was initiated without systemic anticoagulation via bi-femoral cannulation under transthoracic echocardiography guidance. He underwent successful 5-hr apnoeic ventilation-assisted surgical repair of the fistula via a right posterolateral thoracotomy. ECMO was discontinued after 36 hr, and he was discharged to the ward after 33 d in the intensive care unit. Inhalation burn injury can cause a delayed life-threatening tracheoesophageal fistula. Surgical repair can be successfully performed for this condition. VV- ECMO can be used to facilitate prolonged apnoeic surgery and to manage refractory respiratory failure due to this condition.
Accuracy and ‘Error’ in the Production of John Foxe and John Day’s Acts and Monuments
Authors: Rankin Mark 
Published: March 2023

Abstract
This essay focuses upon John Foxe and John Day’s approach to the correction of error in the production of successive editions of Acts and Monuments, especially through the use of slip-cancels, tiny scraps of paper which are intended for pasting over erroneous text, as well as the use of stop-press correction and the labeling of the book’s well-known woodcut illustrations. The bibliographical nature of successive editions of Foxe’s book overseen by Day emerges as even more complex than previously described. The argument adds to scholarly understanding of the goals and methodologies of both Foxe and Day. Bibliographical fluidity associated with John Day’s approach to error during production points toward the better understanding of textual fluidity within successive editions of Foxe’s work.
The Book Factory of Little Gidding
Authors: Ransome David R 
Published: March 2023

Abstract
This paper brings together for the first time the writings of four Little Gidding authors of the early seventeenth century. What they then saw as a merely auxiliary effort became in the nineteenth century a matter of international bibliographical concern. The three siblings, John and Nicholas Ferrar and their older sister Susanna, and John’s son Nicholas, created at least thirty-eight works, not all now extant. They included a commonplace book, translations, promotional works, memoranda of instruction, and—most famously—biblical concordances. Thirty years of study has extended, though not completed, their provenance.
The Publications of A. J. A. Symons
Authors: Edwards A S G 
Published: March 2023

Abstract
This article seeks to record the various writings of A. J. A. Symons (1900–1941). While best known for his biography, The Quest for Corvo (1934) Symons wrote widely on biography and on bibliographical and bibliophilic matters. He also made many contributions to the various publications of the First Edition Club, of which he was Director. In addition, in his later years he wrote extensively on food and wine. The range of his publications indicates the steadily widening extent of his interests in his brief life.
Toward a democratic theory of contagion: virality and performativity with Eve Sedgwick, JL Austin, Hortense Spillers, and Patricia Williams
Authors: Honig Bonnie 
Published: March 2023

Abstract
In Euripides’ Bacchae, the 2015 film The Fits, and John Rawls’ A Theory of Justice (1971), refusal is depicted as worryingly contagious and efforts are made to contain it. But each represents a different model of contagion. In the Bacchae, refusal breaks out all-at-once; in The Fits, a contagion passes through a community in a sequence, mutating as it travels; in A Theory of Justice, refusal is contagious but isolable. In each of these examples, efforts to contain contagion are made via ‘deformatives’, Eve Sedgwick’s term for Austinian performative utterances that shame or stigmatize gender queerness and are themselves, she says, ‘uniquely contagious’. Might their phobic contagion be reworked into a more philic form for democratic theory? Sedgwick might object since she thinks Austin’s exemplary performative is the ‘I do’ of the straight, marrying couple. But How To Do Things with Words shows Austin turning not just to the couple but also to the crowd, which may be gathered or dispersed by another recurring example—that of a bull in the field. This is the first of three counterexamples offered here of the potentially democratic and viral powers of performativity: Austin’s crowd-drawing and-dispersing bull (isolable, yet uncontainable), Hortense Spillers’ viral constitutionalism which may be made to mutate (the sequence model), and Patricia Williams’s alchemy of rights (the all-at-once model of outbreak). In all three, the power and impotence of law is explored: in the comedy of Austin’s memorandum warning about the bull, in Spiller’s constitutionalism, and in Williams’ new rights. In all three contagion is let loose. Efforts to contain it with law, whether by way of property, romance, or whiteness, are mocked, and new consideration of contagion’s democratic possibilities are invited.each virus tells its own story
– J Osmundson, Virology
Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain
Authors: Ao Xiang , Parisien Marc , Zidan Maha , Grant Audrey V. , Martinsen Amy E. , Winsvold Bendik S. , Diatchenko Luda 
Published: March 2023

Abstract
Chronic pain is a prevalent disease with increasing clinical challenges. Genome-wide association studies in chronic pain patients have identified hundreds of common pathogenic variants, yet they only explained a portion of individual variance of chronic pain. With the advances in next-generation sequencing technologies, it is now feasible to conduct rarer variants studies in large-scale databases. Here, we performed gene-based rare variant analyses in 200,000 human subjects in the UK biobank whole-exome sequencing database for investigating 9 different chronic pain states and validated our findings in 3 other large-scale databases. Our analyses identified the SLC13A1 gene coding for sodium/sulfate symporter associated with chronic back pain and multisite pain at the genome-wide level and with chronic headache, knee, and neck and shoulder pain at the nominal level. Seven loss-of-function rare variants were identified within the gene locus potentially contributing to the development of chronic pain, with 2 of them individually associated with back pain and multisite pain. These 2 rare variants were then tested for replication in 3 other biobanks, and the strongest evidence was found for rs28364172 as an individual contributor. Transcriptional analyses of Slc13a1 in rodents showed substantial regulation of its expression in the dorsal root ganglia and the sciatic nerve in neuropathic pain assays. Our results stress the importance of the SLC13A1 gene in sulfate homeostasis in the nervous system and its critical role in preventing pain states, thus suggesting new therapeutic approaches for treating chronic pain in a personalized manner, especially in people with mutations in the SLC13A1 gene.
Comparative genomic analysis identifies great-ape-specific structural variants and their evolutionary significance
Authors: Zhou Bin , He Yaoxi , Chen Yongjie , Su Bing 
Published: March 2023

AbstractDuring the origin of great apes about 14 million years ago, a series of phenotypic innovations emerged, such as the increased body size, the enlarged brain volume, the improved cognitive skill and the diversified diet. Yet, the genomic basis of these evolutionary changes remains unclear. Utilizing the high-quality genome assemblies of great apes (including human), gibbon and macaque, we conducted comparative genome analyses, and identified 15,885 great-ape-specific structural variants (GSSVs), including 8 coding GSSVs resulting in the creation of novel proteins (e.g.ACANandCMYA5). Functional annotations of the GSSV-related genes revealed the enrichment of genes involved development and morphogenesis, especially neurogenesis and neural network formation, suggesting the potential role of GSSVs in shaping the great-ape-shared traits. Further dissection of the brain-related GSSVs show great-ape-specific changes of enhancer activities and gene expression in the brain, involving a group of GSSV-regulated genes (such asNOL3) that potentially contribute to the altered brain development and function in great apes. The presented data highlights the evolutionary role of structural variants in the phenotypic innovations during the origin of the great lineage.
Genomic insights into greater yam tuber quality traits
Authors: Mota Ana Zotta , Dossa Komivi , Lechaudel Mathieu , Cornet Denis , Mournet Pierre , Lopez David , Chaïr Hana 
Published: March 2023

ABSTRACTYams are important tubers widely consumed in developing countries in various forms, mainly boiled, pounded and fried. Tuber quality is a key criterion for acceptance by the various actors in the value chain. However, the genetics of yam tuber quality has not yet been comprehensively investigated. Given this lack of knowledge, we used population genomics and candidate gene association approaches to unravel the genetic basis of the three main quality attributes of boiled yam, namely texture, starch content and colour indices. We re-sequenced the whole genome of 127 yam genotypes with different quality attributes, and performed an enrichment of the already available functional genome annotation using comparative genomics. Population genomics analysis highlighted three main genetic groups and 1,053 genes under selection. We focused this work on three known quality trait-related pathways: pectin, starch content and flavonoid biosynthesis, and inventoried in the genome all the structural genes related to those pathways by comparative genomics. We improved the functional annotation of the three pathways with 48% more genes. A total of 18 candidate genes containing genetic variants significantly associated with the target traits were detected, including eight genes that were also found under selection. The texture-related candidate genes were distributed between the pectin and starch pathways. Overall, the use of comparative genomics has allowed the generation of an unprecedented genomic resource. The improved functional annotation of the yam genome is a promising predictive tool for identifying other core genes associated with any trait of interest to meet the growing need and diversified demands for yams.
Abnormal weather drives disease outbreaks in wild and agricultural plants
Authors: Kirk Devin , Cohen Jeremy M. , Nguyen Vianda , Childs Marissa L. , Farner Johannah E. , Davies T. Jonathan , Flory S. Luke , Rohr Jason R. , O’Connor Mary I. , Mordecai Erin A. 
Published: March 2023

SUMMARYPredicting effects of climate change on plant disease is critical for protecting ecosystems and food production. Climate change could exacerbate plant disease because parasites may be quicker to acclimate and adapt to novel climatic conditions than their hosts due to their smaller body sizes and faster generation times. Here we show how disease pressure responds to the anomalous weather that will increasingly occur with climate change by compiling a global database (5380 plant populations; 437 unique plant–disease combinations; 2,858,795 individual plant–disease samples) of disease incidence in both agricultural and wild plant systems. Because wild plant populations are assumed to be adapted to local climates, we hypothesized that large deviations from historical conditions would increase disease incidence. By contrast, since agricultural plants have been transported globally, we did not expect the historical climate where they are currently grown to be as predictive of disease incidence. Supporting these hypotheses, we found that disease outbreaks tended to occur during periods of warm temperatures in agricultural and cool-climate wild plant systems, but also occurred in warm-adapted wild (but not agricultural) plant systems experiencing anomalously cool weather. Outbreaks were additionally associated with higher rainfall in wild systems, especially those with historically wet climates. Our results suggest that historical climate affects susceptibility to disease for wild plant–disease systems, while warming drives risks for agricultural plant disease outbreaks regardless of historical climate.
Orthogonal inducible control of Cas13 circuits enables programmable RNA regulation in mammalian cells
Authors: Ding Yage , Tous Cristina , Choi Jaehoon , Chen Jingyao , Wong Wilson W. 
Published: March 2023

SUMMARYRNA plays an indispensable role in mammalian cell functions. Cas13, a class of RNA-guided ribonuclease, is a flexible tool for modifying and regulating coding and non-coding RNAs, with enormous potential for creating new cell functions. However, the lack of control over Cas13 activity has limited its cell engineering capability. Here, we present the CRISTAL (Control ofRNA with InducibleSpliTCAs13 Orthologs and ExogenousLigands) platform. CRISTAL is powered by a collection (10 total) of orthogonal split inducible Cas13s that can be turned ON or OFF via small molecules in multiple cell types, providing precise temporal control. Also, we engineered Cas13 logic circuits that can respond to endogenous signaling and exogenous small molecule inputs. Furthermore, the orthogonality, low leakiness, and high dynamic range of our inducible Cas13d and Cas13b enable the design and construction of a robust incoherent feedforward loop, leading to near-perfect and tunable adaptation response. Finally, using our inducible Cas13s, we achieve simultaneous multiplexed control of multiple genesin vitroand in mice. Together, our CRISTAL design represents a powerful platform for precisely regulating RNA dynamics to advance cell engineering and elucidate RNA biology.
Dynamic perceived quality analysis using social media data at macro- and micro-levels
Authors: Yang Tong , Dang Yanzhong , Wu Jiangning 
Published: March 2023

PurposeThis paper aims to propose a method for dynamic product perceived quality analysis using social media data and to achieve a macro–micro combination analysis. The method enables the prioritization of perceived quality attributes and provides perception causes.Design/methodology/approachTo rationalize the macro–micro combination, ANOVA and multiple linear regression were used to identify the main factors affecting perceived quality which served as the combination basis; by using the combination basis for consumer segmentation, macro-knowledge (i.e. attribute importance and quality category of the attribute) is achieved by term frequency-inverse document frequency (TF-IDF)-based attribute importance calculation and KANO-based attribute classification, which is combined with micro-quality diagnostic information (i.e. perceived quality, perception causes and quality parameters). Further, dynamic perception Importance-Performance Analysis (IPA) is built to present the attribute priority and perception causes.FindingsThe framework was validated by the new energy vehicle (NEV) data of Autohome. The results show that price and purchase purpose are the most influential factors of perceived quality and that dynamic perception IPA can effectively prioritize attributes and mine perception causes.Originality/valueThis is one of the first studies to analyze dynamic perceived quality using social media data, which contributes to the research on perceived quality. The paper also contributes by achieving a combined macro–micro analysis of perceived quality. The method rationalizes the macro–micro combination by identifying the factors influencing perceived quality, which provides ideas for other studies using social media data.
Mapping tourism strategy patterns on tourism area life cycle
Authors: Gore Surabhi , Borde Nilesh , Hegde Desai Purva 
Published: March 2023

PurposeTourist destinations are constantly changing products, evolving as per the controls exerted by the stakeholders. The study aims to map the pattern of tourism development and identify the strategies formed at the destination over a seven-decade period for a state as a unit of analysis.Design/methodology/approachThe paper evaluates tourism development through the tourism area life cycle (TALC) model and uses Mintzberg's strategy analysis process to identify strategies. The study involves time series analysis, pattern matching and explanation-building techniques. The TALC is plotted for the number of tourist arrivals from 1947 to 2019, and strategies are mapped for each stage.FindingsThe TALC shows a cycle-recycle pattern of tourism development. The research revealed several strategies at different stages. Both the central and state governments and entrepreneurs, distinctively and in conjunction, have formed strategies. The pattern shows the period of piecemeal and global strategic changes contributing to tourism development.Research limitations/implicationsThe research unearths the strategies that drive the development curves of TALC, emphasising the integration of TALC with other theories. The research also assesses the strategy formed in the pre-tourism stage.Practical implicationsThe research brings to light the use of TALC as a strategic road-mapping tool. In addition, the study emphasises the significance of global and piecemeal strategic periods and stakeholder's regulatory and operational roles.Originality/valueThe research uses a unique methodology that maps the strategies, periods of strategic changes and incremental strategies for each stage of TALC, along with identifying the stakeholders.
Seeking thrills during a crisis? A TSR and hierarchy of effects perspective of the transformative potential of travel
Authors: Mulcahy Rory , Pourfakhimi Shahab , Prayag Girish , Falatoonitoosi Elham , Scott Noel 
Published: March 2023

Purpose
This study aims to theorise and empirically test a model based on the hierarchy of effects behavioural learning approach (“do-think-feel”) to explain how travel during a crisis assists consumer well-being. The paper also examines whether the effect travel has on well-being is serially mediated by perceived risk and resilience and moderated by the personality trait of sensation-seeking.

Design/methodology/approach
This research uses a quasi-experimental design involving Australian consumers based on a sample of n = 307 who had travelled and n = 277 who had not during the COVID-19 pandemic (N = 584). A replication study (N = 290) is also undertaken to assess the robustness of the hierarchy of effects uncovered in the main study. Data were analysed using structural equation modelling (SEM) and Hayes PROCESS macro.

Findings
The results reveal travellers have significantly higher levels of both hedonic and eudaimonic well-being than non-travellers, suggesting the transformative potential of travel experiences during a crisis. The transformative potential of travel is driven by perceived risk and psychological resilience, which mediate the relationship between travel frequency and well-being. Further, spotlight moderation analysis demonstrates that the effect of travel on well-being is most profound for those with lower levels of sensation-seeking. These relationships are also confirmed in the replication study.

Originality/value
This research is among the first in transformative service research (TSR) to test the mediators of perceived risk and resilience together in a singular study, showing how experiences such as travel are potentially transformative. It also evaluates personality traits such as sensation-seeking as a moderating factor, which is uncommon in TSR. Further, this study empirically validates a do–think–feel behavioural learning approach, as opposed to other hierarchy of effects sequences that are dominant in TSR and the wider services marketing literature.
The relationship between extreme contexts, organizational change capacity, and firm product and process innovation
Authors: Akgün Ali E. , Cemberci Murat , Kircovali Selim 
Published: March 2023

PurposeThis study investigates the mediating role of organizational change capacity (OCC) in the relationship between the perception of extreme contexts and firm product and process innovation, which was not empirically investigated in the literature. In addition, this study explores the moderating role of the perception of extreme contexts-related variables, which were not operationalized in ordinary firms, on the relationship between OCC and firm product and process innovation.Design/methodology/approachA questionnaire-based research was conducted to test the suggested hypotheses. The data were gathered from 90 firms during the peak period of COVID-19.FindingsThis study shows that OCC, which covers contexts, process and learning dimensions, fully mediates the relationship between the perception of extreme contexts and firm product and process innovation. Also, this study discovers that the perception of extreme contexts, including temporal ordering of extremity, the magnitude of consequences, proximity among people and operational deficiencies, positively moderate the relationship between OCC and firm product innovation.Research limitations/implicationsThis study has constraints inherited in survey design, primarily sampling and country context.Originality/valueThis study identifies, conceptualizes and operationalizes the term extreme context, conceptually argued for particular organizations/units in ordinary/mundane organization settings so far. In addition, this study extends the current understanding of how the perception of extreme contexts interacts with a firm's capability to increase innovation efforts. Further, this study shows how OCC mediates the relationship between extreme contexts and firm product and process innovation.