bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival Status, Length of Stay, and Predictors of Mortality Among Neonates Admitted in the Neonatal Intensive Care Unit of Gurage Zone Public Hospitals
Authors: Chekole Bogale , Terefe Tamene Fetene , Tenaw Shegaw Geze , Zewudie Bitew Tefera , GebreEyesus Fisha Alebel , Kassaw Amare , Gelaw Walle Belete , Aynalem Mewahegn Agerie , Tadesse Betelihem , Mesfin Yibeltal , Argaw Muche , Abebe Haimanot , Tesfa Shegaw , Tamene Zeleke Fentahun 
Published: July 2023

Background Many countries need to accelerate their progress to achieve the sustainable development goal target of neonatal death. It is still high in Ethiopia. Thus, this study aimed to assess the mortality predictors and length of hospital stay among Neonates admitted to the Neonatal Intensive Care Unit of Gurage zone public Hospitals. Method In this study, a facility-based retrospective follow-up study was applied among 375 neonates admitted to the NICU of selected public hospitals in the Gurage zone from June 1, 2019 to June 30, 2021. The researchers used Epi-Data entry 3.1 for the data entry and then exported it to STATA version 14 for analysis. The Kaplan–Meier survival curve and log-rank test were used to estimate and compare the survival time of categorical variables, respectively. Result The researchers observed about 85 (22.7% with 95%CI: 18.7, 27.2) deaths from the 2305 person-days follow-up. The median survival time was 14 days. The overall incidence density rate was 36.9 per 1000 person-days observed (95%CI: 29.8, 45.6). Perinatal asphyxia (AHR: 2.9[CI: 1.8; 4.8]), cesarean section as a mode of delivery (AHR: 1.1[CI; 1.01; 1.15]), maternal age of greater or equal to 35 years (AHR: 1.1[95% CI: 1.01, 1.15]), and twin pregnancy (AHR: 2.3[95% CI: 1.2, 4.3]) were predictors of neonatal mortality. Conclusion The survival rate of neonates was higher compared to other studies. So, to reduce the burden of neonatal mortality, health care providers should give special attention to twin pregnancies, neonates delivered via cesarean section, and neonates with a problem of perinatal asphyxia.
Influence of Family and Friends Level of Social Support on Psychological Symptoms Among the Older Adults in Nigeria
Authors: Olabisi Oluwaseyi Isaiah , Faronbi Joel , Adedeji Peter , Ademuyiwa Grace , Gambari Yusuf , Lasisi Aishat 
Published: July 2023

Introduction Numerous studies have established the importance of social support on psychological symptoms among older adults, however, the distinct contribution of different levels of family and friends’ social support has not been thoroughly assessed. Objectives This study determined the contribution of different levels of friend and family social support (high, moderate, low) on psychological symptoms among the older adults. Methods A cross-sectional study was conducted among 538 older adults attending outpatient clinics at two selected teaching Hospitals in Nigeria from February to July, 2021.The data was collected using the 7-item Generalized Anxiety Disorders Scale, Patient Health Questionnaire (PHQ-9), and the Multidimensional Scale of Perceived Social Support. The data was analyzed with SPSS version 23 and logistic regression was used for the inferential analysis. Results Older adults with moderate social support from family were 3.6 more likely to have depression symptoms than those with high family social support (AOR = 3.623, 95%CI 1.275–2.875, P = .020). Also, those with moderate family social support (AOR = 2.875, 95%CI 2.425–11.875, P = .002), low family social support (AOR = 2.966, 95%CI 1.312–3.875, P = .007), and low friends social support (AOR = 2.966, 95%CI 1.312–3.875, P = .009) were more likely to have anxiety symptoms than those with high social support. Conclusion High social support confers a protective measure against depression and is effective in reducing psychological symptoms among older adults.
Placenta Accreta Spectrum: A Current Literature Review
Authors: Abdelhafez Mohsen M. A. , Ahmed Karim A. M. , Mohd Daud Mohd Nazri Bin , Eldiasty Aya M. , Jeffree Mohammad Saffree , Kadir Fairrul , pg Baharuddin Dg Marshitah , Than Win Win , Hayati Firdaus , bt.Azizan Nornazirah , Sumpat Doreen 
Published: July 2023

Objective: This literature review was designed to highlight the most up-to-date and evidence-based interventions, whenever available, regarding diagnostic imaging modalities and management strategies for patients, with the placenta accreta spectrum. Materials and Methods: A comprehensive review of the literature was conducted using database searches in Science Direct, Google Scholar, and PubMed to locate the most up-to-date information, related to this topic. Results: The placenta accreta spectrum has an unclear etiology, with cesarean delivery and placenta previa being the most implicated factors. Conclusion: There is a growing global consensus that the two main risk factors for placenta accreta are placenta previa and prior cesarean delivery. Up-to-date, grayscale sonography combined with Doppler interrogation is thought to be the best first-line assistance, for the identification of abnormal placental invasion. Cesarean hysterectomy, with placenta left in situ, is the classical surgical treatment.
Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
Authors: Yoshida Kazuhiro , Muramatsu Masamichi , Shimizu Hiroyuki 
Published: July 2023

Abstract
Background
Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelitis.

Methods
In this study, we measured neutralizing antibody titers against six clinical EV-D68 isolates in nine intravenous immune globulin (IVIG) products commercially available in Japan to assess their potential as therapeutic options for severe EV-D68 infection.

Results
Seven IVIG products manufactured from Japanese donors contained high neutralizing antibody titers (IC50 = 0.22–85.01 µg/mL) against all six EV-D68 strains. Apparent differences in neutralizing titers among the six EV-D68 strains were observed for all IVIG products derived from Japanese and non-Japanese blood donors.

Conclusions
High levels of EV-D68–neutralizing antibodies in IVIG products manufactured from Japanese donors suggest that anti-EV-D68 antibodies are maintained in the Japanese donor population similarly as found in foreign blood donors. Apparent differences in neutralizing antibody titers against the six EV-D68 strains suggest distinct antigenicity among the strains used in this study regardless of the genetic similarity of EV-D68.
Prevalence and predictors of depressive and anxiety symptoms in a sample of women who use drugs in Tanzania: the key role of drug use stigma
Authors: Saleem Haneefa T. , West Nora S. , Likindikoki Samuel 
Published: July 2023

AbstractBackgroundGlobally, women who use drugs face multiple health vulnerabilities, including poor mental health. Little is known about the mental health burden among women who use drugs in sub-Saharan Africa. This cross-sectional study examined the prevalence and predictors of depressive and anxiety symptoms among a sample of women who use drugs in Dar es Salaam, Tanzania.MethodsWe administered a cross-sectional survey to a non-random sample of 200 women who use drugs in Dar es Salaam between November 2018 and March 2019. We used descriptive statistics to characterize the study sample and fitted separate logistic regression models to assess depressive and anxiety symptoms and their predictors.ResultsThe percentages of women reporting depressive and anxiety symptoms were 67.5% and 43.7%, respectively. Internalized drug use stigma (AOR = 1.34, 95% CI: 1.03–1.75) and prior attempts to stop heroin use (AOR = 2.99, 95% CI: 1.28-7.00) were associated with depressive symptoms. Enacted drug use stigma from health workers (AOR = 2.02, 95% CI: 1.34–3.04) and anticipated drug use stigma from family (AOR = 1.49, 95% CI: 1.02–2.16) were associated with anxiety symptoms.ConclusionsDepressive and anxiety symptoms were high among our study sample, with higher reports of symptoms of depression than anxiety. Drug use stigma was a key factor that contributed to elevated symptoms of depression and anxiety.
Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/ JAK-STAT signaling pathway
Authors: Long Yujun , Wang Ying , Shen Yidong , Huang Jing , Li Yamin , Wu Renrong , Zhao Jingping 
Published: July 2023

Abstract
Background
Abnormal activation of microglia is involved in the pathogenesis of schizophrenia. Minocycline and antipsychotics have been reported to be effective in inhibiting the activation of microglia and thus alleviating the negative symptoms of patients with schizophrenia. However, the specific molecular mechanism by which minocycline and antipsychotics inhibit microglial activation is not clear. In this study, we aimed to explore the molecular mechanism of treatment effect of minocycline and antipsychotics on schizophrenia.

Methods
Microglia cells were activated by lipopolysaccharide (LPS) and further treated with minocycline, haloperidol, and risperidone. Then cell morphology, specific marker, cytokines, and nitric oxide production process, and the proteins in related molecular signaling pathways in LPS-activated microglia were compared among groups.

Results
The study found that minocycline, risperidone, and haloperidol significantly inhibited morphological changes and reduced the expression of OX-42 protein induced by LPS. Minocycline significantly decreased the production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-1beta (IL-1β). Risperidone also showed significant decrease in the production of IL-6 and TNF-α, while haloperidol only showed significant decrease in the production of IL-6. Minocycline, risperidone, and haloperidol were found to significantly inhibit nitric oxide (NO) expression, but had no effect on inducible nitric oxide synthase (iNOS) expression. Both minocycline and risperidone were effective in decreasing the activity of c‑Jun N‑terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in the mitogen-activated protein kinases (MAPKs) signal pathway. Additionally, minocycline and risperidone were found to increase the activity of phosphorylated-p38. In contrast, haloperidol only suppressed the activity of ERK. Minocycline also suppressed the activation of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), while risperidone and haloperidol only suppressed the activation of STAT3.

Conclusions
The results demonstrated that minocycline and risperidone exert stronger anti-inflammatory and neuroprotective effects stronger than haloperidol, through MAPKs and Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathways in BV2 cells stimulated with LPS, revealing the underlying mechanisms of minocycline and atypical antipsychotics in the treatment of negative schizophrenia symptoms.
Identification of high-risk patterns of myopia in Chinese students based on four major behavioral risk factors: a latent class analysis
Authors: Li Dan-Lin , Yin Zhi-Jian , Li Yue-Zu , Zheng Ya-Jie , Qin Yu , Liang Gang , Pan Chen-Wei 
Published: July 2023

Abstract
Background
Myopia is prevalent in children and adolescents. Understanding the effect of multiple behaviors and their latent patterns on ocular biometric parameters may help clinicians and public health practitioners understand the behavioral risk pattern of myopia from a person-centered perspective. The purpose of this study was to identify the patterns of four major behavioral risk factors associated with myopia, including time spent outdoors, digital screen time, sleep duration, and performance of Chinese eye exercises. The study also examined the relationships between these behavioral patterns and myopia as well as ocular biometric parameters in a sample of Chinese college students.

Methods
This study included 2014 students from the Dali University Students Eye Health Study. The average age of the subjects was 19.0 ± 0.9 years old, ranging from 15.7 to 25.1 years old. Each participant’s refractive status was measured using an autorefractor without cycloplegia and ocular biometric parameters were measured using an IOL Master. Behavioral risk factors were collected using a pre-designed self-administered questionnaire. Latent class analysis (LCA) was performed to identify cluster patterns of various behaviors.

Results
The prevalence of myopia was 91.8% in this population. The 2-class model was selected for the LCA based on goodness-of-fit evaluation metrics. Among the overall study sample, 41.1% and 58.9% were assigned into the high-risk and low-risk class, respectively. The risk of myopia [odds ratio (OR) = 2.12, 95% confidence interval (CI) = 1.52–3.14], high myopia (OR = 1.43, 95% CI = 1.14–1.78) and axial length/corneal radius (AL/CR) ratio of more than 3.0 (OR = 1.82, 95% CI = 1.22–2.72) were significantly higher in the high-risk compared with low-risk class.

Conclusions
Chinese university students showed differential risks of myopia and could be subdivided into high- and low-risk clusters based on four behavioral variables.
The impact of assisted reproductive technology treatment coverage on marriage, pregnancy, and childbirth in women of childbearing age: an interrupted time-series analysis
Authors: Yun Il , Cha Wontae , Nam Chung-Mo , Nam Jin Young , Park Eun-Cheol 
Published: July 2023

Abstract
Background
Korea is encountering major challenges related to its declining birth rate and aging population. Various policies have been introduced to prevent further population decrease and boost the birth rate, but their effectiveness has not been verified. Therefore, this study examined the effects of assisted reproductive technology (ART) insurance coverage on marriage, pregnancy, and childbirth in women of childbearing age.

Methods
All information on marriage, pregnancy, childbirth of women of childbearing age was obtained from Statistics Korea and Korean National Health Insurance Service database. During a total follow-up period of 54 months (July 2015 to December 2019), an average of 12,524,214 women of childbearing age per month, and 29,701 live births per month were included in the analysis. An interrupted time series with segmented regression was performed to analyze the time trend and changes in outcomes.

Results
The implementation of ART coverage policies had no significant impact on marriage or pregnancy rates. However, it did affect multiple pregnancy and multiple birth rates, which increased by 1.0% (Exp(β3) = 1.010, P-value = 0.0001) and 1.4% (Exp(β3) = 1.014, P-value = < 0.0001), respectively, compared to the pre-intervention period. Although the effect of covering ART treatment on total birth rates were not confirmed, a slightly slower decline was observed after the intervention (Exp(β1) = 0.993, P-value = < 0.0001, Exp(β1 + β3) = 0.996 P-value = 0.012).

Conclusion
This study identified the effects of ART health insurance coverage policy on the rates of multiple pregnancies and births. After the policy implementation, the downward trend in the total birth rate reduced slightly. Our findings suggest that interventions to support infertile couples should be expanded to solve the problem of low fertility rates.

Plain english summary
To address the intricate problems related to low birth rates, the Korean government introduced a policy that provides financial support and health insurance coverage for assisted reproductive technology (ART) treatment for infertile couples. As a result of evaluating the effectiveness of the ART coverage policy, it led to higher rates of pregnancies and births. In addition, although the total birth rate has been continuously decreasing over time, the decline may have been slowed down slightly by this policy.
Patient-reported measures outcomes: modern evaluation of oral health
Authors: Douglas-de-Oliveira Dhelfeson Willya , Chen Kitty Jieyi 
Published: July 2023

AbstractPatient reported outcomes have become important, with instruments (patient reported outcomes measures - PROMs) being used to assess treatment success and patient satisfaction. In this editorial, the dental PROM context is presented, and submissions are invited for a special collection from BMC Oral Health entitled ‘Patient-reported outcomes in dentistry’.
Patient-shared knowledge and information in clinical decision-making: an international survey of the perspectives and experiences of naturopathic practitioners
Authors: Steel Amie , Brand Sarah , Leach Matthew , Lloyd Iva , Ward Vicky 
Published: July 2023

Abstract
Introduction
Most knowledge translation models pay relatively little attention to patient-held knowledge and are largely based on the premise that researchers and clinicians hold all valuable knowledge, and patients are passive recipients of such knowledge. Counter to this clinician- and researcher-centred lens is a growing interest and awareness of patients as experts in their health. While naturopathic medicine is described and experienced as a patient-centred system of traditional medicine, the position of patient-held knowledge is unclear particularly when considered alongside their use of other more objective forms of knowledge such as research evidence.

Methods
This international online cross-sectional survey aimed to explore naturopathic practitioners’ perceptions of the value and contribution of patient-shared knowledge and information within the context of naturopathic clinical consultations.

Results
The survey was completed by 453 naturopathic practitioners (response rate: 74.3%). Approximately two-thirds (68.2%) of respondents reported using information shared by the patient. Most rated ‘information provided by the patient’ as either ‘extremely important’ (60.7%) or ‘very important’ (31.4%) to patients. Highest levels of trust were reported for information provided by the patient (‘completely’: 9.9%; ‘a lot’: 53.6%). Most practitioners indicated they trusted knowledge and information derived from the patient’s personal health history ‘completely’ (n = 79; 21.8%) or ‘a lot’ (n = 226; 62.4%) from the patient’s perspective of living with a health condition (‘completely’ [n = 63, 17.4%]; ‘a lot’ [n = 224, 61.9%]). Patients were the highest ranked stakeholder group (mean: 1.5) perceived to influence NP use of patient experience of living with a health condition to inform clinical decision-making.

Conclusion
Researchers and policy makers are increasingly focused on the value of the ‘expert patient’ in clinical decision-making, yet health professionals’ report challenges and, in some cases, resistance to meaningfully engaging with patient-shared knowledge in practice. However, our study has found patient-shared knowledge – inclusive of patient experience of their health condition – is among the knowledge used and trusted by naturopathic practitioners to inform their clinical decision-making. This study both offers insights into the knowledge translation behaviours of an under-researched health profession and provides a novel contribution to the wider aim of adopting patient-shared knowledge into clinical care more generally.
An evaluation of truncated birth histories for the rapid measurement of fertility and child survival
Authors: Masquelier Bruno , Menashe-Oren Ashira , Reniers Georges 
Published: July 2023

Abstract
Background
Full birth histories (FBHs) are a key tool for estimating fertility and child mortality in low- and middle-income countries, but they are lengthy to collect. This is not desirable, especially for rapid turnaround surveys that ought to be short (e.g., mobile phone surveys). To reduce the length of the interview, some surveys resort to truncated birth histories (TBHs), where questions are asked only on recent births.

Methods
We used 32 Malaria Indicator Surveys that included TBHs from 18 countries in sub-Saharan Africa. Each set of TBHs was paired and compared to an overlapping set of FBHs (typically from a standard Demographic and Health Survey). We conducted a variety of data checks, including a comparison of the proportion of children reported in the reference period and a comparison of the fertility and mortality estimates.

Results
Fertility and mortality estimates from TBHs are lower than those based on FBHs. These differences are driven by the omission of events and the displacement of births backward and out of the reference period.

Conclusions
TBHs are prone to misreporting errors that will bias both fertility and mortality estimates. While we find a few significant associations between outcomes measured and interviewer’s characteristics, data quality markers correlate more consistently with respondent attributes, suggesting that truncation creates confusion among mothers being interviewed. Rigorous data quality checks should be put in place when collecting data through this instrument in future surveys.
‘The tabloid test’: a qualitative interview study on the function and purpose of termination of pregnancy review committees in Victoria, Australia
Authors: Bowman-Smart Hilary , Keogh Louise , Haining Casey M. , O’Rourke Anne , de Crespigny Lachlan , Savulescu Julian 
Published: July 2023

AbstractBackgroundTermination of pregnancy (TOP) is not an uncommon procedure. Availability varies greatly between jurisdictions; however, additional institutional processes beyond legislation can also impact care and service delivery. This study serves to examine the role institutional processes can play in the delivery of TOP services, in a jurisdiction where TOP is lawful at all gestations (Victoria, Australia). As per theAbortion Law Reform Act 2008, TOPs post-24 weeks require the approval of two medical practitioners. However, in Victoria, hospitals that offer post-24 week TOPs generally require these cases to additionally go before a termination review committee for assessment prior to the service being provided. These committees are not stipulated in legislation. Information about these committees and how they operate is scarce and there is minimal information available to the public.MethodsTo trace the history, function, and decision-making processes of these committees, we conducted a qualitative interview study. We interviewed 27 healthcare professionals involved with these committees. We used purposive sampling to gain perspectives from a range of professions across 10 hospitals. Interviews were transcribed verbatim, identifying details removed and inductive thematic analysis was performed.ResultsHere, we report the three main functions of the committees as described by participants. The functions were to protect: (1) outward appearances; (2) inward functionality; and/or, (3) service users. Function (1) could mean protecting the hospital’s reputation, with the “Herald Sun test”—whether the TOP would be acceptable to readers of the Herald Sun, a tabloid newspaper—used as a heuristic. Function (2) related to logistics within the hospital and protecting the psychological wellbeing and personal reputation of healthcare professionals. The final function (3) related to ensuring patients received a high standard of care.ConclusionsThe primary functions of these committees appear to be about protecting hospitals and clinicians within a context where these procedures are controversial and stigmatized. The results of this study provide further clarity on the processes involved in the provision of TOPs at later gestations from the perspectives of the healthcare professionals involved. Institutional processes beyond those required by legislation are put in place by hospitals. These findings highlight the additional challenges faced by patients and their providers when seeking TOP at later gestations.