bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Digital Health Interventions for Cancer Prevention Among People Living With Disabilities in the United States: A Scoping Review
Authors: Ejezie Chinenye Lynette , Sacca Lea , Ayieko Sylvia , Burgoa Sara , Zerrouki Yasmine , Lobaina Diana , Okwaraji Goodness , Markham Christine 
Published: January 2025

ABSTRACTBackgroundThe use of digital health strategies for cancer care increased dramatically in the United States over the past 4 years. However, a dearth of knowledge remains about the use of digital health for cancer prevention for some populations with heath disparities. Therefore, the purpose of the present scoping review was to identify digital health interventions for cancer prevention designed for people with disabilities.MethodsThis scoping review was guided by the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses extension for scoping reviews and the Arksey and O'Malley methodological framework. The Embase, PubMed, Ovid MEDLINE, and CINAHL/EBSCO databases were searched for peer‐reviewed articles published from database inception to February 5, 2024. Reports published in English of studies that employed digital health strategies for cancer prevention, were conducted among people with disabilities regardless of age, and were conducted in the United States were included.FindingsFollowing screening for eligibility, seven articles were identified. The types of disabilities were cancer (n = 4), bipolar I or II disorder (n = 1), obesity (n = 1), and deafness (n = 1). Interventions focused on education (n = 4), screening (n = 3), smoking cessation (n = 3), physical activity (n = 1), and cessation support (n = 1). Digital health strategies consisted of educational content delivered online, text messaging, interactive educational games, and downloadable informational applications. The common outcome of interest across all manuscripts was intervention efficacy.InterpretationOverall, limited research is available to evaluate the use of digital health for cancer prevention among people with disabilities. This review identified gaps in knowledge that, if addressed, may help guide continued innovation in the use of digital health strategies for cancer prevention among people with disabilities.
The Association Between Serum Gamma‐Glutamyl Transferase and Gastrointestinal Cancer Risk: A Systematic Review and Meta‐Analysis
Authors: Ramandi Alireza , George Jacob , Behnoush Amir Hossein , Delavari Alireza , Mohammadi Zahra , Poustchi Hossein , Malekzadeh Reza 
Published: January 2025

ABSTRACTBackgroundGamma‐glutamyl transferase (GGT) has been shown to have associations with several diseases including cancers. Previous studies have investigated the effect of GGT levels on the gastrointestinal (GI) cancer incidence. We aim to systematically investigate these studies to provide better insights into the interrelationship between GGT and GI cancers.MethodsOnline databases were searched to find relevant studies investigating different GGT levels' effects on the incidence of GI cancers including colorectal, esophageal, liver, pancreas, gastric, and biliary duct cancers. Random‐effect meta‐analysis was conducted to pool the hazard ratios (HRs) of GGT quartiles (Qs) effect on cancer incidence.ResultsA total of 26 studies were included in the final review, 12 of which underwent meta‐analysis that investigated 11 million patients. Based on the meta‐analysis, Q4 patients had a 69% higher hazard of GI cancer incidence (HR 1.69, 95% CI 1.41–2.02, p‐value < 0.001). The hazard ratio significance was also similar for Q3 (HR 1.22, 95% CI 1.15–1.30, p‐value < 0.001) and Q2 (HR 1.10, 95% CI 1.05–1.16, p‐value =0.002) of GGT. Colorectal and liver cancers showed a higher hazard ratio among Q2, Q3, and Q4 of GGT compared to Q1. In pancreas and bile duct cancers, only Q4 of GGT had significantly higher HR. Q3 and Q4 of GGT levels had statistically significant associations with gastric cancer incidence.ConclusionHigher GGT levels correlate with higher rates of GI cancer incidence, especially in colorectal and hepatic cancers. Future studies should investigate this biomarker's potential role in risk assessment for digestive cancers.
Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma
Authors: Zhu Changyu , Liu Heshu , Li Zhixin , Shi Yijun , Zhao Jingyang , Bai Yuping , Chen Qian , Li Wei 
Published: January 2025

ABSTRACTBackgroundThis study aims to elucidate the expression pattern of SERPINE1, assess its prognostic significance, and explore potential therapeutic drugs targeting this molecule.Methods and ResultsIn this study, we delved into the variations in gene mutation, methylation patterns, and expression levels of SERPINE1 in head and neck squamous cell carcinoma (HNSCC) and normal tissues, leveraging comprehensive analyses of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The connection between the biological function of the gene and prognosis was scrutinized through immune infiltration and enrichment analyses. Concurrently, we assessed the potential therapeutic value of SERPINE1 through drug sensitivity analysis. It was observed that, particularly in human papillomavirus (HPV) negative HNSCC, SERPINE1 exhibited elevated expression levels, correlating with poorer prognosis. The infiltration levels of eight cell types, such as eosinophils, Tgd, and macrophages, showed a positive correlation with SERPINE1 expression, whereas infiltration levels of four cell types, including cytotoxic cells, B cells, and pDCs, displayed a negative correlation. Furthermore, copy number variations of SERPINE1 were primarily characterized by homologous amplification, positively correlating with its expression, while methylation showed an inverse correlation. The outcomes of drug sensitivity analysis underscored the potential of SERPINE1 as a therapeutic target.ConclusionElevated expression of SERPINE1 in HNSCC is intricately linked with adverse prognostic outcomes and has the potential to influence the immune microenvironment. Subsequent investigations are imperative to fully elucidate the prognostic implications of SERPINE1 as a biomarker and to unlock its therapeutic promise as a target for intervention.
Self‐assembled Palmitic Acid‐modified Thymopentin Functions as a Delivery System of Nanovaccine for Cancer Immunotherapy
Authors: Chen Danhong , Ye Xiaoyun , Xu Ran , Li Wanqiong , Xiao Youmei , Niu Xiaoshuang , Yang Xin , Wang Mengfan , Su Ye , Zeng Wenxuan , Luo Feiyu , Gao Yanfeng 
Published: January 2025

AbstractIn clinical practice, thymopentin (TP‐5) is a commonly utilized immunomodulatory peptide drug. The relatively short half‐life of TP‐5, however, significantly limits its applicability in immunotherapy. Inspired by the structure of the TLR2 ligand lipopeptide Pam3CSK4, fatty acid‐modified TP‐5 peptides were designed and synthesized in this study. Utilizing its amphiphilicity, they were sonicated to assemble into nanoparticles with the diameters of approximately 100 nm. Compared with TP‐5, TP‐5 monopalmitate‐modified nanoparticle has immune‐activating properties both in vivo and in vitro. It markedly increased TNF‐α secretion from RAW264.7 cells and aided in the maturation of DCs. The immunogenicity of OVA model antigen was increased in vivo when capsulated by TP‐5 lipopeptide nanoparticle, which considerably slowed the growth of B16‐OVA melanoma. This fatty acid‐modified TP‐5 assembled nanoparticle offers a straightforward and useful delivery system for the design of innovative nanovaccine for cancer immunotherapy.
A Rare Case of Wolfram Syndrome Presenting With Tuberculous Meningitis: A Case Report
Authors: Khan Nabiha , Ashraf Muhammad Usama , Khan Sadia , Khan Allahdad , Shahzad Humna , Habib Mudasira , Kamal Aseel 
Published: January 2025

ABSTRACTWolfram syndrome is an extremely rare condition composed of a tetrad of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. When concurrently presenting with another condition, such as tuberculous meningitis, the widespread range of resulting symptoms delays the establishment of diagnosis and treatment, which results in increased patient morbidity.
Concomitant Pulmonary and Biliary Manifestations of Ulcerative Colitis: A Case Report
Authors: Shrestha Pritee , Shara Philip , Adio Babajide 
Published: January 2025

ABSTRACTUlcerative colitis can present with extra‐intestinal manifestations, including interstitial lung disease and primary sclerosing cholangitis. When pulmonary symptoms precede gastrointestinal, diagnosis can be challenging. Consideration of Ulcerative colitis in patients with unexplained lung and hepatic pathology is crucial, as a failure of timely intervention can lead to multiorgan complications.
Quadruple N‐Methylation of Ethylenediamine with CO2 and H2 over Supported Sulfurized Re Catalysts
Authors: Wang Min , Kanemaru Daigo , Yabushita Mizuho , Okuma Kazuki , Shono Tomohiro , Nakagawa Yoshinao , Tomishige Keiichi 
Published: January 2025

AbstractSulfurized Re clusters supported on carbon black were demonstrated to exhibit high catalytic activity and stability in the quadruple N‐methylation of ethylenediamine (EDA) using CO2 and H2 as a C1 source and reductant, respectively. EDA underwent the step‐by‐step N‐functionalization consisting of N‐formylation and N‐methylation to be the target product N,N,N′,N′‐tetramethylethylenediamine (TetraM‐EDA), whose maximum yield reached 84% under the optimum conditions. In this reaction, N,N′‐dimethylethylenediamine and its N‐formylated compounds were found as the important intermediates. The ReSx species in the clusters consisting of both metallic and sulfurized Re were assumed from various characterizations and control experiments to exhibit the better activity for the hydrogenation of N‐formylated compounds than the clusters composed of metallic and oxidized Re species, enabling the high‐yielding production of TetraM‐EDA. Another plausible role of sulfurized Re species was assumed to offer high resistance against highly basic N‐methylated EDAs in this reaction. The synergy between metallic and sulfurized Re species is the key to the high activity for the quadruple N‐methylation of EDA.
Novel techniques in bio‐oil production through catalytic pyrolysis of waste biomass: Effective parameters, innovations, and techno‐economic analysis
Authors: Rezvani Behnam 
Published: January 2025

AbstractThe increasing demand for sustainable energy sources has driven significant advancements in the field of bio‐oil production. This article scrutinizes catalytic pyrolysis for its ability to improve bio‐oil characteristics through the use of catalysts and optimization of process conditions. Critical parameters such as reaction temperature, heating rate, biomass feedstock, and catalyst type are analyzed for their influence on bio‐oil properties. Innovations in catalyst design, including the development of hierarchical zeolites, metal oxides, and bifunctional catalysts, are explored for their efficacy in deoxygenation, minimizing coke formation, and stabilizing bio‐oil. Additionally, advanced techniques like catalytic plasma pyrolysis and co‐pyrolysis with diverse feedstocks are investigated to further enhance bio‐oil quality. The techno‐economic analysis is conducted to assess the feasibility of these novel techniques, considering fixed and variable costs, and the market potential of the produced bio‐oil. This analysis aims to provide a holistic perspective on the economic viability and scalability of catalytic pyrolysis for bio‐oil production. This research contributes to the very recent advancement of bio‐oil production technologies, offering insights into optimizing process parameters and catalyst innovations. The findings facilitate more efficient and economically viable bio‐oil production methods, supporting the transition to renewable energy sources.
Photoinduced Metal‐/Additive‐Free Difluoromethylation of N‐Heteroaromatics†
Authors: Zhu Congjun , Shen Yangyang , Guo Tao , Yang Qing , Zhao Dongpu , Yang Huiqing , Xie Jin 
Published: January 2025

Comprehensive SummaryHerein, we report a photo‐induced, metal‐/additive‐free protocol for the difluoromethylation of N‐heteroaromatics with [bis(difluoroacetoxy)iodo]benzene as the difluoromethylation reagent. The protocol affords difluoromethylated N‐heteroaromatics in moderate to good yield (up to 91%). The transformation is compatible with a wide range of substrates and has good tolerance towards various functional groups. Moreover, the synthetic value of this method is further demonstrated by applications in gram‐scale synthesis and the late‐stage functionalization of biologically important molecules.
A Phase 1 Randomized Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Escalating Oral Doses of Dordaviprone and the Effects of Food on the Bioavailability of Dordaviprone in Healthy Adult Subjects
Authors: Faison Shamia L. , Batonga Joelle , Arumugham Thangam , Bartkus Angela , Morrison Marion , Mullin Mark J. , Tippin Tim , Naderer Odin 
Published: January 2025

AbstractDordaviprone (ONC201) is a novel, small molecule imipridone with antitumor effects in glioma patients. This study evaluated the pharmacokinetics and safety of dordaviprone following single escalating doses (Part A), as a capsule content mixed with applesauce or Gatorade (sports drink) [Part B1]), and with or without food [Part B2]. The most common treatment‐emergent adverse events pooled across study parts (Parts A, B1, and B2) were headache, dizziness, and headache, respectively; all were mild. Systemic dordaviprone exposure increased dose proportionally following administration of 125‐625 mg of dordaviprone. Following dordaviprone capsule contents sprinkled on applesauce or dissolved in sports drink, the geometric mean ratios, and 90% confidence intervals (CIs) of the dordaviprone area under the concentration versus time curve (AUC) fell within the bioequivalence (BE) limits of 80.00%‐125.00%; however, for Cmax the 90% CI lower limit (0.70) fell below BE limits when sprinkled on applesauce. The geometric mean ratios and 90% CIs of dordaviprone administered under fed versus fasted conditions fell within BE limits of 80.00%‐125.00% for the AUC, indicating no food effect on total exposure; however, maximum concentration (Cmax) (90% CI 0.55, 0.67) fell below BE limits.
Integrated Magnetic and Electrical Geophysical Methods for Detecting Concealed Porphyry Copper Deposits in Sedimentary Basins: A Case Study From the Western Liupanshan Basin, Northwest China
Authors: Tao Rui , Qiang Tai , Gong Tingting , Sun Yongliang , Mei Chao , Ren Rui , Yang Ye 
Published: January 2025

ABSTRACTExploration for concealed porphyry copper (Cu) deposits in sedimentary basins is challenging. Integrated geophysical exploration methods, combining electrical and magnetic techniques, have proven to be highly effective in the search for concealed metal deposits. This study focuses on the Yueliangshan area within the western Liupanshan Basin, utilising high‐precision (1: 10,000) ground magnetic surveys and induced polarisation sounding for Cu exploration. The goal is to interpret geophysical anomalies to delineate Cu mineralization zones, providing a reliable theoretical basis for subsequent engineering drilling. High‐precision ground magnetic surveys indicate that magnetic anomalies are primarily caused by Proterozoic to Palaeozoic metamorphosed volcanic‐sedimentary rock series and magmatic intrusions. These magnetic sources are distributed along a northwest‐southeast regional structural uplift zone, with the upper interface buried approximately 400 m deep. The magnetic bodies trend southwest and are steeply inclined. The induced polarisation sounding results reveal that sulphide mineralized alteration zones at the margins of concealed granodiorite bodies are responsible for the high polarizability characteristics observed in exploration sections 2 and 8. Compared to geophysical parameters from ground magnetic surveys, high polarizability obtained from induced polarisation measurements are the most effective indicators for identifying porphyry bodies that have undergone mineralized alteration. It is proposed that engineering drilling at the sites of maximum anomalies caused by mineralized alteration offers a high feasibility for discovering Cu deposits. Finally, this study summarises the comprehensive exploration indicators for concealed porphyry Cu deposits in sedimentary basins and proposes a generalised exploration model.
Association between prophylactic antibiotics for endometrial biopsy and the incidence of pelvic inflammatory disease: A retrospective cohort study
Authors: Ishida Risa , Sasabuchi Yusuke , Koga Kaori , Izumi Gentaro , Shigemi Daisuke , Matsui Hiroki , Yasunaga Hideo , Osuga Yutaka 
Published: January 2025

SynopsisProphylactic antibiotics for endometrial biopsy may not reduce the risk of pelvic inflammatory disease, and their routine use may not be recommended.
MT‐BAAN: Multi‐View Topological Bilinear Aggregation Attention Network Model for Alzheimer's Disease Diagnosis
Authors: Liu Jie , Zeng Weiming , Zhang Wei , Zhang Ru , Luo Sizhe 
Published: January 2025

ABSTRACTAlzheimer's disease (AD) and mild cognitive impairment (MCI) are common cognitive disorders. Research has shown that cognitive decline is closely related to abnormal connections between different functional areas of the brain. However, research on brain functional network (BFN) has mainly focused on individual topological structures, seldom considering the sparsity of the BFNs and the complexity of multi‐level interactions among brain regions. To tackle this problem, in this article, we propose a multi‐view topological bilinear aggregation attention network model (MT‐BAAN) for disease diagnosis and brain network analysis. Based on rs‐fMRI data, the model mainly includes a multi‐view graph construction module (MVGC), a feature enhancement module (FEM), a dual‐level attention module (DLAM), and a graph relation convolution network module (GRCN). MVGC module uses two sparse methods to construct high‐view and low‐view graphs and retains fully connected BFN topology as the full‐view, aiming at capturing multi‐scale topological features. FEM and DLAM utilize bilinear aggregation and attention mechanisms, respectively, to learn topological features and obtain weight coefficients that reflect the importance of different network views. The GRCN module employs two convolutional operators to learn the BFN topology information at the node and network levels and completes the classification. The experimental results indicate that the complementary learning of multi‐view topologies can effectively improve model performance. Across binary classification tasks and ternary classification tasks, MT‐BAAN shows superior performance compared to other experimental methods, which is valuable for research and clinical diagnosis of attention deficit disorder AD and MCI.
Promoting Angiogenesis/Osteogenesis by a New Copper/Magnesium Hydroxide Hybrid Nanoparticle: In Vitro and In Vivo Investigation
Authors: Khalkhali Parsa , Omidi Meisam , Masson‐Meyers Daniela S. , Akbari Babak , Dehghan Mohammad Mehdi , Aminianfar Hossein , Farzad‐Mohajeri Saeed , Mansouri Vahid , Nikpasand Amin , Tayebi Lobat 
Published: January 2025

ABSTRACTIn this study, a new hybrid nanoparticle composed of magnesium hydroxide and copper oxide (Mg(OH)2/CuO) with an optimized ratio of magnesium (Mg) to copper (Cu) was designed and incorporated into a 3D‐printed scaffold made of polycaprolactone (PCL) and gelatin. These hybrid nanostructures (MCNs) were prepared using a green, solvent‐free method. Their topography, surface morphology, and structural properties were characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X‐ray diffraction (XRD), and X‐ray photoelectron spectroscopy (XPS). The fabricated 3D‐printed PCL/Gelatin/MCN scaffolds were investigated in vitro and in vivo. Cell viability tests on murine calvarial preosteoblasts (MC3T3‐E1) and human umbilical vein endothelial cells (HUVECs) demonstrated that the scaffolds could induce proper cell proliferation. Additionally, the angiogenic and osteogenic properties of the constructs were evaluated using alkaline phosphatase (ALP) activity, osteogenesis‐related, and angiogenesis‐related gene expression tests. The in vivo study was conducted using a rat calvarial defect model, which confirmed the superior angiogenic and osteogenic properties of the PCL/gelatin/MCN scaffolds compared to PCL/Gelatin and PCL/Gelatin/Mg(OH)2 scaffolds. Overall, the PCL/Gelatin/MCN scaffolds showed promising potential for bone regeneration, particularly for critical‐sized defects where proper angiogenesis is essential for tissue reconstruction.
A nosographic and etiopathogenetic framework for subchondral bone marrow lesions in the knee: A narrative review
Authors: Andriolo Luca , Sangiorgio Alessandro , Galea Anthony , Linder‐Ganz Eran , Orth Patrick , Shabshin Nogah , Yamamoto Takuaki , Filardo Giuseppe 
Published: January 2025

AbstractPurposeSubchondral bone marrow lesions (BMLs) are present in a wide range of pathologies with different prognoses. Thus, a careful diagnosis is mandatory to address them with the proper treatment. The aim of this review was to examine BMLs aetiology and their relationship with biomechanical and biological factors, to identify BMLs and help clinicians to properly recognize and treat each of these common alterations.DiscussionEach pathological pattern is determined by different aetiologic factors, which may act alone or synergically in determining the BML. These factors include major or minor trauma, bone tissue alterations, altered joint load distribution, coagulopathies, and hormonal alterations. This narrative review encompasses these patterns and factors providing a nosographic and etiopathogenetic framework for subchondral BMLs in the knee.ConclusionWhile the field is still heterogeneous in the definition of the nosographic framework of BMLs, there is a trend with the convergence towards a common terminology, which could help to shed more light on the complex and varied field of BMLs. Future studies should focus on better understanding the etiopathogenetic mechanisms, which can concur with the development of BML from one side, and, on the other hand, may represent targets for future treatments to address BMLs and preserve or restore the osteochondral unit.Level of EvidenceExpert Opinion, Level V.