bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subliminal Blueprints for Other Dimensions: The Time‐warped Sanatorium of the Quay Brothers
Authors: Carels Edwin 
Published: June 2023

AbstractOver recent decades, the Quay Brothers (identical twins Stephen and Timothy) have developed an aesthetic language that is immediately recognisable and has gained them many admirers – no matter what media they express themselves in. They combine filmmaking, drawing, calligraphy, puppetry and moody chiaroscuro décor and installations. Edwin Carels, former curator of the International Film Festival Rotterdam, guides us through one of their recent installations.
Crack‐Induced Superelastic, Strength‐Tunable Carbon Nanotube Sponges
Authors: Ye Ziming , Zhao Bo , Wang Qi , Chen Kun , Su Man , Xia Zhiyuan , Han Lei , Li Meng , Kong Xiaobing , Shang Yuanyuan , Liang Jiyong , Cao Anyuan 
Published: June 2023

AbstractLightweight strong aerogels have many applications, but they suffer from the trade‐off between key mechanical properties, and it remains challenging to realize superelastic aerogels simultaneously possessing high strength and excellent structural recovery. Herein, a strategy to overcome such a problem by designing a carbon nanotube (CNT)‐based aerogel consisting of flexible‐rigid core‐shell structure, which achieve a combination of excellent properties including superelasticity (complete recovery at 90%), high strength (over 12 MPa at 90%) and wide tunability (from 101 kPa to 4.5 MPa at 50% strain), is presented. It is found that the outer rigid but brittle amorphous carbon shells crosslink the CNT cores and crack into orderly distributed segments during the first compression cycle, while the flexible CNT cores ensure the integrity of the overall skeleton and tolerance to large deformation. This designed CNT composite sponges exhibit overall superior mechanical properties than previously reported foams/aerogels, and due to such unique crack‐induced superelasticity mechanism, potential applications such as pressure sensors with wide‐range tailored sensitivity and high‐performance energy absorbers have been developed. This flexible‐rigid core‐shell synergia may provide further insight for tunable high‐strength aerogel design and innovative applications.
Photocatalyzed Direct α‐Alkylation of Esters Using Styrenes
Authors: Wang Pengzhi , Bay Anna V. , Farnam Emelia J. , Scheidt Karl A. 
Published: June 2023

AbstractA mild photocatalyzed approach to achieve the α‐alkylation of esters via formation of an α ‐radical is disclosed here. Cesium enolates of esters were generated in situ using Cs2CO3 as a base. A subsequent photocatalyzed oxidation at the α‐carbon of these enolates produced an α‐radical that was added into activated alkenes. This is the first example accessing the α‐carbon radical of esters in photoredox catalyed transformations.
Benzodithiazoles‐Sulfoximines: Preparation, Properties and Reactivities as Radical Perfluoroalkylating Agents
Authors: Duhail Thibaut , Messaoudi Samir , Dagousset Guillaume , Marrot Jérôme , André‐Barrès Christiane , Magnier Emmanuel , Anselmi Elsa 
Published: June 2023

AbstractWe describe the preparation of S‐perfluoroalkyl benzodithiazole trioxides as radical perfluoroalkylating reagents. Their syntheses were performed on a multi‐gram scale by an oxidative cyclization connecting the nitrogen of a sulfoximine and a sulfur atom previously introduced in theorthoposition of this group. The structures and properties of these new molecules were carefully examined by X‐Ray diffraction, DFT calculations and cyclic voltammetry. These data clearly highlight the enhanced reactivity of these cyclic sulfoximines compared to their open analogues. This was confirmed by photoredox catalysis experiments that revealed interesting reactivity, most especially for the introduction of di‐ and monofluoroalkyl chains.
Coupling Borophene to Graphene in Air‐Stable Heterostructures
Authors: Jugovac Matteo , Cojocariu Iulia , Brondin Carlo Alberto , Crotti Alessandro , Petrović Marin , Bonetti Stefano , Locatelli Andrea , Menteş Tevfik Onur 
Published: June 2023

AbstractArtificial 2D van der Waals heterostructures with controllable vertical stacking and rotational orientation exhibit multifaceted electronic properties that are appealing for applications in fields ranging from optoelectronics to energy storage. Along with transition metal dichalcogenides and graphene, borophene has recently emerged as a promising building block for 2D devices due to its conductive nature as well as its exceptional mechanical and electronic properties. Here, it is demonstrated that the combination of the dissolution‐segregation process and chemical vapor deposition allows for the synthesis of graphene/borophene heterostructures of the highest crystalline and chemical quality, in which graphene sits on top of the borophene layer with metallic character. The formation of laterally distinct micron‐sized areas allows a comparative study of borophene, graphene, and the graphene–borophene heterostack in terms of their electronic properties and stability in a reactive environment. Whereas pristine borophene is particularly prone to oxidation, the graphene–borophene heterostack is chemically inert and enables the conservation of borophene's character even after exposure to air. This study opens up new perspectives for the scalable synthesis of graphene–borophene heterostacks with enhanced ability to preserve the metallic character and electronic properties of borophene.
Coupling Benzylamine Oxidation with CO2 Photoconversion to Ethanol over a Black Phosphorus and Bismuth Tungstate S‐Scheme Heterojunction
Authors: Zhang Minghui , Mao Yuyin , Bao Xiaolei , Zhai Guangyao , Xiao Difei , Liu Dong , Wang Peng , Cheng Hefeng , Liu Yuanyuan , Zheng Zhaoke , Dai Ying , Fan Yuchen , Wang Zeyan , Huang Baibiao 
Published: June 2023

AbstractPhotoconversion of CO2 and H2O into ethanol is an ideal strategy to achieve carbon neutrality. However, the production of ethanol with high activity and selectivity is challenging owing to the less efficient reduction half‐reaction involving multi‐step proton‐coupled electron transfer (PCET), a slow C−C coupling process, and sluggish water oxidation half‐reaction. Herein, a two‐dimensional/two‐dimensional (2D/2D) S‐scheme heterojunction consisting of black phosphorus and Bi2WO6 (BP/BWO) was constructed for photocatalytic CO2 reduction coupling with benzylamine (BA) oxidation. The as‐prepared BP/BWO catalyst exhibits a superior photocatalytic performance toward CO2 reduction, with a yield of 61.3 μmol g−1 h−1 for ethanol (selectivity of 91 %).In situ spectroscopic studies and theoretical calculations reveal that S‐scheme heterojunction can effectively promote photogenerated carrier separation via the Bi−O−P bridge to accelerate the PCET process. Meanwhile, electron‐rich BP acts as the active site and plays a vital role in the process of C−C coupling. In addition, the substitution of BA oxidation for H2O oxidation can further enhance the photocatalytic performance of CO2 reduction to C2H5OH. This work opens a new horizon for exploring novel heterogeneous photocatalysts in CO2 photoconversion to C2H5OH based on cooperative photoredox systems.
Role of Extracellular Vesicles in the Propagation of Lung Fibrosis in Systemic Sclerosis
Authors: Mouawad Joe E. , Sanderson Matthew , Sharma Shailza , Helke Kristi L. , Pilewski Joseph M. , Nadig Satish N. , Feghali‐Bostwick Carol 
Published: June 2023

ObjectivesSystemic sclerosis (SSc) has the highest mortality rate among the rheumatic diseases, with lung fibrosis leading as the cause of death. A characteristic of severe SSc‐related lung fibrosis is its progressive nature. Although most research has focused on the pathology of the fibrosis, the mechanism mediating the fibrotic spread remains unclear. We hypothesized that extracellular vesicle (EV) communication drives the propagation of SSc lung fibrosis.MethodsEVs were isolated from normal (NL) or SSc‐derived human lungs and primary lung fibroblasts (pLFs). EVs were also isolated from human fibrotic lungs and pLFs induced experimentally with transforming growth factor‐β (TGFβ). Fibrotic potency of EVs was assessed using functional assays in vitro and in vivo. Transmission electron microscopy, nanoparticle tracking analysis, real‐time quantitative polymerase chain reaction (RT‐qPCR), immunoblotting, and immunofluorescence were used to analyze EVs, their cargo, extracellular matrix (ECM) fractions, and conditioned media.ResultsSSc lungs and pLFs released significantly more EVs than NL lungs, and their EVs showed increased fibrotic content and activity. TGFβ‐stimulated NL lung cores and pLFs increased packaging of fibrotic proteins, including fibronectin, collagens, and TGFβ, into released EVs. The EVs induced a fibrotic phenotype in recipient pLFs and in vivo in mouse lungs. Furthermore, EVs interacted with and contributed to the ECM. Finally, suppressing EV release in vivo reduced severity of murine lung fibrosis.ConclusionsOur findings highlight EV communication as a novel mechanism for propagation of SSc lung fibrosis. Identifying therapies that reduce EV release, activity, and/or fibrotic cargo in SSc patient lungs may be a viable therapeutic strategy to improve fibrosis.
Distributed event‐triggered optimal bipartite consensus control for multiagent systems with input delay via reinforcement learning method
Authors: Zhang Jing , Ma Hui , Zhang Yun , Chen Yang 
Published: June 2023

AbstractIn this article, an optimal bipartite consensus control (OBCC) scheme is proposed for heterogeneous multiagent systems (MASs) with input delay by reinforcement learning (RL) algorithm. A directed signed graph is established to construct MASs with competitive and cooperative relationships, and model reduction method is developed to tackle input delay problem. Then, based on the Hamilton–Jacobi–Bellman (HJB) equation, policy iteration method is utilized to design the bipartite consensus controller, which consists of value function and optimal controller. Further, a distributed event‐triggered function is proposed to increase control efficiency, which only requires information from its own agent and neighboring agents. Based on the input‐to‐state stability (ISS) function and Lyapunov function, sufficient conditions for the stability of MASs can be derived. Apart from that, RL algorithm is employed to solve the event‐triggered OBCC problem in MASs, where critic neural networks (NNs) and actor NNs estimate value function and control policy, respectively. Finally, simulation results are given to validate the feasibility and efficiency of the proposed algorithm.
Survival benefit of anlotinib in T790M‐positive non‐small‐cell lung cancer patients with acquired osimertinib resistance: A multicenter retrospective study and exploratory in vitro study
Authors: Chen Ya , Liu Hongyu , Hu Nana , Wang Yanan , Yang Zhengyu , Zhang Junqiang , Han Baohui 
Published: June 2023

AbstractObjectivesAcquired resistance represents a bottleneck to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in lung cancer. Our study aimed to explore the efficacy of antiangiogenic‐based therapy in osimertinib‐resistant NSCLC patients and assess the efficacy of anlotinib in vitro study.MethodsOur multicenter study retrospectively collected 268 osimertinib‐resistant NSCLC patients with EGFR T790M mutation and explored the efficacy of anlotinib in patients and in vitro.ResultsPFS was significantly longer in the antiangiogenic‐based therapy group than in the immunotherapy group (HR: 0.71, p = 0.050) and the chemotherapy group (HR: 0.28, p = 0.001). Both the ORR and DCR of the antiangiogenic‐based group were higher than the immunotherapy group and the chemotherapy group. Subgroup analysis showed a trend of more benefits from the anlotinib‐based therapy than the bevacizumab‐based therapy in terms of PFS (HR: 0.63, p = 0.087) and OS (HR: 0.52, p = 0.063). In vitro assays verified that anlotinib alone or combined with osimertinib exerted potent cytotoxicity to T790M‐mutant H1975 cell line with acquired osimertinib resistance.ConclusionsOur study suggested that antiangiogenic‐based therapy might improve PFS and OS in EGFR‐mutant NSCLC patients with acquired resistance to osimertinib. Moreover, anlotinib‐based therapy could be a promising effective treatment for this group of patients.
Anti‐Migratory and Cytotoxic Activities of [Ga(8‐hydroxyquinolinato)3]: Roles of Endogenous Cu(II) and Drug‐Induced Phenotypic Changes
Authors: Kuramarohit Serene , Yaourtis Andria M. , Nguyen Annie , Wood Michelle L. , Levina Aviva , Lay Peter A. 
Published: June 2023

AbstractAs shown by IncuCyte Zoom imaging proliferation assays, invasive triple‐negative human breast MDA‐MB‐231 cancer cells treated with sub‐toxic doses (5.0–20 μM, 72 h) of [GaQ3] (Q=8‐hydroxyquinolinato) caused profound morphological changes and inhibition of cell migration, which were likely due to terminal cell differentiation or similar phenotypical change. This is the first demonstration of potential use of a metal complex in differentiation anti‐cancer therapy. Additionally, a trace amount of Cu(II) (0.20 μM) added to the medium dramatically increased [GaQ3] cytotoxicity (IC50~2 μM, 72 h) due to its partial dissociation and the action of the HQ ligand as a Cu(II) ionophore, as shown with electrospray mass spectrometry and fluorescence spectroscopy assays in the medium. Hence, cytotoxicity of [GaQ3] is strongly linked to ligand binding of essential metal ions in the medium, for example, Cu(II). Appropriate delivery mechanisms of such complexes and their ligands could enable a powerful new triple therapeutic approach for cancer chemotherapy, including cytotoxicity against primary tumour, arrest of metastases, and activation of innate and adaptive immune responses.
Organic‐Inorganic Hybrid Crystal‐Assisted Etching of Nickel Foam for the Collectively Exhaustive Electrochemical Performance of Oxygen Evolution Reaction
Authors: Thangasamy Pitchai , He Rong , Chen Xinqi , Yu Kunpeng , Randriamahazaka Hyacinthe , Chen Zheng , Luo Hongmei , Zhou Xiao‐Dong , Zhou Meng 
Published: June 2023

AbstractIn this work, an organic‐inorganic hybrid crystal, violet‐crystal (VC), was used to etch the nickel foam (NF) to fabricate a self‐standing electrode for the water oxidation reaction. The efficacy of VC‐assisted etching manifests the promising electrochemical performance towards the oxygen evolution reaction (OER), requiring only ~356 and ~376 mV overpotentials to reach 50 and 100 mA cm−2, respectively. The OER activity improvement is attributed to the collectively exhaustive effects arising from the incorporation of various elements in the NF, and the enhancement of active site density. Furthermore, the self‐standing electrode is robust, exhibiting a stable OER activity after 4,000 cyclic voltammetry cycles, and ~50 h. The anodic transfer coefficients (αa) show that the first electron transfer step is the rate‐determining step on the surface of NF‐VCs‐1.0 (NF etched by 1 g of VCs) electrode, while the chemical step involving dissociation following the first electron transfer step is identified as the rate‐limiting step in other electrodes. The lowest Tafel slope value observed in the NF‐VCs‐1.0 electrode indicates the high surface coverage of oxygen intermediates and more favorable OER reaction kinetics, as confirmed by high interfacial chemical capacitance and low charge transport/interfacial resistance. This work demonstrates the importance of VCs‐assisted etching of NF to activate the OER, and the ability to predict reaction kinetics and rate‐limiting step based on αa values, which will open new avenues to identify advanced electrocatalysts for the water oxidation reaction.
Recent Advances in Aerobic Oxidative of C−H Bond by Molecular Oxygen Focus on Heterocycles
Authors: Zhang Lei‐Yang , Wang Nai‐Xing , Lucan Dumitra , Cheung William , Xing Yalan 
Published: June 2023

AbstractAerobic oxidative cross‐coupling represents one of the most straightforward and atom‐economic methods for construction of C−C and C−X (X=N, O, S, or P) bonds using air as a sustainable external oxidant. The oxidative coupling of C−H bonds in heterocyclic compounds can effectively increase their molecular complexity by introducing new functional groups through C−H bond activation, or by formation of new heterocyclic structures through cascade construction of two or more sequential chemical bonds. This is very useful as it can increase the potential applications of these structures in natural products, pharmaceuticals, agricultural chemicals, and functional materials. This is a representative overview of recent progress since 2010 on green oxidative coupling reactions of C−H bond using O2 or air as internal oxidant focus on Heterocycles. It aims to provide a platform for expanding the scope and utility of air as green oxidant, together with a brief discussion on research into the mechanisms behind it.
Magnetically Stimulated Bio‐ and Electrochemical Systems: State‐of‐the‐Art, Applications, and Future Directions
Authors: Melo Antonio F. A. A. , Singh Salam J. , Chinnamuthu Paulsamy , Crespilho Frank N. , Rydzek Gaulthier 
Published: June 2023

AbstractMagnetically stimulated bio‐and electrochemical systems have gained increasing importance in recent years due to their enhanced sensitivity and selectivity, improved spatial control, and ability to operate in complex environments, offering significant advantages over conventional systems. Essentially, this review provides a comprehensive and informative survey about the state‐of‐art as well as the recent efforts and applications made in the past decade, with a focus on new functional magnetic materials and nano‐architectonic interfaces that have led to promising advances in biosensors, biofuel cells, and their integration into devices. Future directions and perspectives are also discussed.
Cost‐effectiveness of root canal treatment compared with tooth extraction in a Swedish Public Dental Service: A prospective controlled cohort study
Authors: Wigsten Emma , Kvist Thomas , Husberg Magnus ,   EndoReCo, Davidson Thomas 
Published: June 2023

AbstractObjectivesTo evaluate the cost‐effectiveness of root canal treatment (RCT) compared with a tooth extraction in a general dental practice setting, with reference to cost per quality‐adjusted life‐year (QALY) gained over 1 year.Material and MethodsThis is a prospective controlled cohort study based on patients either starting RCT or undergoing extraction at one of six Public Dental Service clinics in the county of Västra Götaland, Sweden. From a total of 65 patients, 2 comparable groups were formed: 37 started RCT and 28 underwent extraction. A societal perspective was used for the cost calculations. QALYs were estimated, based on the EQ‐5D‐5L given to the patients at their first treatment appointment and then after 1, 6, and 12 months.ResultsThe total mean cost of RCT ($689.1) was higher than for extraction ($280.1). For those patients whose extracted tooth was replaced, the costs were even higher ($1245.5). There were no significant intergroup differences in QALYs, but a significant improvement in health state values in the tooth‐preserving group.ConclusionsIn the short term, extraction was cost‐effective compared with preserving a tooth with RCT. However, the potential need for future replacement of the extracted tooth, by an implant, fixed prosthesis, or removable partial dentures, may change the calculation in favor of RCT.
Terpyridine Based Heteroleptic Ruthenium Complexes: Influence of Donor and Acceptor Ligands in Photosensitization
Authors: Jain Nimisha , Mary Angelina , Singh Tanu , Gadiyaram Srushti , Joshi Jyoti , Jose D. Amilan , Naziruddin Abbas Raja 
Published: June 2023

AbstractWe report heteroleptic ruthenium complexes of terpyridine (tpy) ligands with directly linked carboxylic acid anchors. These complexes feature methyl or methoxy‐substituted 4′−Phtpy as donor ligands. We prepared these heteroleptic complexes from the ruthenium (II) precursor via a milder route to preclude the homoleptic complex formation. The donor−acceptor arrangement of tpy ligands in these ruthenium complexes renders visible light absorption giving metal and ligand‐to‐ligand charge transfer excitations at c.a. 490 nm. We evaluate the effect of the tpy donor substituents on the light‐harvesting ability in Dye‐Sensitized Solar Cells (DSSCs) and compare their photosensitizing ability with heteroleptic complexes bearing phenyl spacer at the acceptor end. Further, scrutinizing their photovoltaic performance, we studied their electron transfer kinetics in DSSCs using electrochemical impedance spectroscopy. This paper presents the structure‐photosensitization relationship of these heteroleptic ruthenium complexes through a combined experimental and computational approach.
Clathrochelate Complexes Containing Axial Cymantrene and Tromancenium Moieties
Authors: Thaler Reinhard , Kopacka Holger , Wurst Klaus , Müller Thomas , Neururer Florian R. , Hohloch Stephan , Lippmann Petra , Ott Ingo , Bildstein Benno 
Published: June 2023

AbstractNew clathrochelate complexes of manganese, iron and cobalt containing peripheral organometallic manganese moieties cymantrene or tromancenium were synthesized via self‐assembly from di/tri‐topic dioximes, metal templates and cymantrene/tromancenium boronic acid pinacol esters. These air‐stable, highly colored, oligometallic complexes are composed of various combinations of MnIFeIIMnI, MnICoIIMnI, MnIMnIIMnIIMnI and MnICoIICoIIMnI metal assemblies with corresponding complicated magnetic and electrochemical properties. Full spectroscopic and structural characterization by 1H/11B/13C NMR, HRMS, IR, UV‐vis, single crystal XRD and CV (cyclic voltammetry) is provided. Tetrametallic complexes containing tromanceniumyl substituents with two CoII or MnII central metals exhibit promising anticancer properties against different tumor cell lines.
Vitamin C supplementation lowers advanced glycation end products (AGEs) and malondialdehyde (MDA) in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled clinical trial
Authors: Rabizadeh Soghra , Heidari Firouzeh , Karimi Reza , Rajab Armin , Rahimi‐Dehgolan Shahram , Yadegar Amirhossein , Mohammadi Fatemeh , Mirmiranpour Hossein , Esteghamati Alireza , Nakhjavani Manouchehr 
Published: June 2023

AbstractThis study evaluated how daily vitamin C administration impacts systemic oxidative stress and inflammation and its safety in T2D patients. This randomized, double‐blinded, placebo‐controlled, parallel‐arm clinical trial included 70 patients with T2D. They were allocated to receive either 500 mg/day of vitamin C or a matching placebo for 8 weeks. Of the 70 subjects assigned to the trial, 57 were included in the statistical analysis (vitamin C: n = 32, placebo: n = 25). Inflammatory and oxidative markers, including advanced glycation end products (AGEs), malondialdehyde (MDA), advanced oxidation protein products (AOPP), oxidized low‐density lipoprotein (ox‐LDL), highly sensitive C‐reactive protein (hs‐CRP), tumor necrosis factor‐α (TNF‐α), and ferric reducing ability of plasma (FRAP) were measured at baseline and the end of the trial. In addition, vitamin C tolerance was evaluated. A nutritionist visited all participants for a standard diabetic regimen. Following vitamin C supplementation, the serum levels of MDA (p‐value < .001) and AGEs (p‐value = .002) demonstrated a significant decrease after controlling for multiple confounders, including age, blood pressure, waist circumference, HbA1C, TG, and LDL‐C, while no significant changes were observed for AOPP (p‐value = .234) and ox‐LDL (p‐value = .480). The FRAP showed an increasing trend as an antioxidant marker but was not statistically significant (p‐value = .312). The hs‐CRP and TNF‐α had no significant changes (p‐value: .899 and .454, respectively). Also, no major adverse events were observed. Vitamin C supplementation may be beneficial in reducing AGEs and MDA in patients with T2D.