bluuebunny/crossref_metadata_2025_split huggingface dataset:
How is parental education associated with infant and young child feeding in Bangladesh? A systematic literature review
Authors: Sarkar Plabon , Rifat M. A. , Bakshi Progati , Talukdar Imdadul Haque , Pechtl Sarah M. L. , Battle Tobias Lindström , Saha Sanjib 
Published: December 2022

Abstract
Background
Education is expected to bring about positive behavioral changes that could lead to better health, especially parental education is one of the most important factors for a child’s health and development. However, the role of parental education on optimal infant and young child feeding (IYCF) practices in Bangladesh is inconclusive. The objective of this review is to summarize how parental education is associated with IYCF practices in Bangladesh.
Method
This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. A systematic literature search was conducted in PubMed, Web of Science, Embase, and Google Scholar. Record searching, study selection and data extraction was performed using Endnote online and Covidence software, respectively. The Newcastle-Ottawa scale was used for quality assessment of the included studies.
Results
Out of 414 initial hits, 34 studies were included for this review. Of the included studies, 32 were cross-sectional, one was a randomized controlled trial, and one was a retrospective cohort. Most of the studies (n=24) were nationally representative whereas 10 studies had populations from district and sub-district level. Included studies considered different IYCF related indicators, including breastfeeding (n=22), complementary feeding (n=8), both breastfeeding and complementary feeding (n=2), both breastfeeding and bottle feeding (n=1), and pre-lacteal feeding (n=1). Parental education was found positively associated with complementary feeding practices. However, the role of parental education on breastfeeding, in general, was ambiguous. High parental education was associated with bottle-feeding practices and no initiation of colostrum.
Conclusion
Public health interventions need to focus not only on non- and/or low educated parents regarding complementary feeding but also on educated mothers on initiation of colostrum and proper breastfeeding practices.
Registration
This systematic review is registered to PROSPERO (https://www.crd.york.ac.uk/prospero/) with registration ID: CRD42022355465
Social networks and other forgotten components of the WaSH enabling environment in Fiji
Authors: Love Mark , Beal C. , Pene S. , Rarokolutu Rt. T. , Whippy A. , Taivoce S. , Shrestha S. , Souter R. T. 
Published: December 2022

AbstractPacific Island countries have among the lowest access to improved drinking water sources and sanitation services in the world. Due to geography, climate, the high frequency, and severity of disasters, transportation difficulties and resource constraints, government and private sector support to rural populations are limited and likely to remain so. However, the unique demographic characteristics of the region see considerable support flowing to rural areas from village kin in urban centres and overseas, hinged on strong socio-cultural norms of reciprocity, self-help, and obligation. Focusing on Fiji, this paper examines how select social networks are being used to support improved rural water and sanitation outcomes. Results demonstrate that kinship-orientated urban–rural linkages, select customary norms, relations and practices, common interest associations (such as village development committees), and select social media groups, all constitute critical components of the WaSH enabling environment in Fiji. Given the unique character of the Pacific Islands region, leveraging existing social networks to support improved rural water and sanitation outcomes may constitute a fruitful community water management ‘plus’ strategy for both governments and non-government organisations seeking to strengthen rural water and sanitation service outcomes.
A two-dimensional analytical model for heavy metal contaminants transport in permeable reactive barrier
Authors: Jiang Jie , Luo Hao-Hao , Wang Shu-Fei , Su Jian , Yu Yun-Dong 
Published: December 2022

Abstract
Permeable reactive barrier (PRB) remediation technology has been widely used in the remediation of groundwater contamination. In numerical simulations, neglecting the non-uniform distribution of heavy metal contamination along the depth may lead to deviations between simulation results and reality. The distribution of heavy metals in the soil layer around a non-ferrous mining area in Hezhou, Guangxi, southern China was investigated, and it was found that the standard Gaussian function could well describe the non-uniform distribution of heavy metals in the soil layer. A two-dimensional analytical model solved by the finite element method was used to simulate the migration process of heavy metal contamination in the aquifer and PRB. The results show that the uniform distribution of contaminants along the depth ignores the dilution effect, which may underestimate the service life of the PRB and lead to an overly conservative design of the PRB. The breakthrough time of the PRB decreases with the increase of the maximum initial concentration (Cin,max) and the high concentration range (σ), and increases almost linearly with the barrier thickness (Lw). An optimal design method for PRB location and thickness is proposed, which can provide a reference for the engineering application of PRB.
Thiabendazole degradation by photo-NaOCl/Fe and photo-Fenton like processes, using copper slag as an iron catalyst, in spiked synthetic and real secondary wastewater treatment plant effluents
Authors: García-Estrada Reyna , Arzate Sandra , Ramírez-Zamora Rosa-María 
Published: December 2022

Abstract
Thiabendazole degradation (TBZD) in diferent types of water matrices was assessed by applying two Advanced Oxidation Processes, both using simulated solar light (SSL), copper slag (CS) as an iron based catalyst, and separately H2O2 or NaOCl as oxidants. First, optimum conditions for TBZD were evaluated in distilled water, TBZD = 90% at 60 min for CS-H2O2-SSL, and 92% of TBZD in a twelfth of the time by the system CS-NaOCl-SSL; minimum TBZ depletion variations were observed between the first and the fifth reuse test: 88 ± 2% for CS-H2O2-SSL (60 min) and 90 ± 1% for CS-NaOCl-SSL (5 min). Those conditions were tested using a synthetic (SE) and a real secondary effluent (RE) from a wastewater treatment plant. The CS-H2O2-SSL system achieved TBZD of 88 and 77% after 90 min for SE and RE, with kinetic constants of 0.024 and 0.016 min−1, respectively, whereas photo-NaOCl/Fe showed values of 0.365 and 0.385 min−1 for SE and RE, achieving a 94% TBZD removal in both types of water at 10 min. That might be related to the formation of Cl· and HO• during the photo-NaOCl/Fe process, highlighting that the CS-NaOCl-SSL is an attractive option that has great possibilities for scaling up by a better knowledge in real aqueous matrices.
A Novel Cu(II)-Iodine Catalyzed Hantzsch Type Synthesis of 2-Aminothiazole Derivatives
Authors: Radhika Sankaran , Yamuna Purushothaman , Anilkumar Gopinathan 
Published: December 2022

Abstract:
Heterocycles having nitrogen and sulphur atoms attract chief attention due to their importance in diverse fields, especially in medicinal chemistry and pharmaceutical industry. Among those, 2-aminothiazole, one of the most flexible and pervasive heterocyclic scaffolds found in many natural and synthetic products, exhibits a wide variety of biological activities. A one-pot method for the synthesis of 2-aminothiazoles through Cu(II)-iodine-catalyzed Hantzsch condensation has been achieved for the first time. This novel green methodology facilitates the formation of a broad range of 2-aminothiazole derivatives utilizing catalytic quantities of Cu(II) salts and iodine, incorporating various methyl aryl ketones and thiourea as substrates. This novel strategy involves a Hantzsch-type condensation between thiourea and in situ generated α-iodoketones, formed from the reaction of methyl aryl ketones and iodine. The present protocol reveals PEG-400 as the best solvent, which furnishes moderate to good yields of the desired 2-aminothiazole derivatives. The addition of a catalytic quantity of copper acetate ensures the continuous availability of iodine for several catalytic cycles, as copper(II) allows the oxidation of iodide to iodine. The feasibility of this novel route is studied with electron-withdrawing, electron-donating, and halo-substituted derivatives of methyl aryl ketones with thiourea to confirm the functional group compatibility of the reaction. Moreover, this efficient strategy evades the direct use of noxious and lachrymatory α–halocarbonyls as reaction substrates and strong oxidants. Using a catalytic quantity of iodine in the reaction makes the separation of the desired products much easier by reducing the amount of unwanted side-products than utilizing a stoichiometric amount of iodine.
Level of Knowledge and Attitudes Towards Palliative Care for People with
Advanced Dementia in Spain: Role of Professional and Academic Factors
Authors: Pérez-Ros Pilar , Cauli Omar , Julián-Rochina Iván , Long Carol O. , Chover-Sierra Elena 
Published: December 2022

Background:
Providing quality end-of-life care to individuals with advanced dementia is crucial. To date, little attention has been paid to palliative care knowledge and attitudes toward palliative care for people with advanced dementia in Spain

Objectives:
To investigate the knowledge of and attitudes toward palliative care for advanced dementia among registered nurses and physicians in Spain.

Design and Methods:
A descriptive, cross-sectional survey design was used. This study included a convenience sample of 402 nurses (n = 290) and physicians (n = 112). Two instruments were administered: demographic characteristics and Spanish version of the Questionnaire of Palliative Care for Advanced Dementia (qPAD-SV). Descriptive statistics and multiple regression were used for data analysis.

Results:
Overall, the nurses and physicians had moderate mean scores for both knowledge of and attitudes regarding palliative care for advanced dementia. Physicians had a higher level of knowledge (p<0.05) compared to nurses. Additionally, physicians and nursing staff who had professional experience/education in geriatrics and those who had received palliative care and hospice training had greater (p<0.01) knowledge of palliative care. In addition, healthcare professionals who had received dementia care training and who had worked in nursing homes had higher levels (p<0.05) of knowledge and attitudes toward palliative care.

Conclusion:
This study indicates the need to provide nurses and physicians with more education for select groups of professionals who have had limited education and experience in caring for older adults with advanced dementia.
MicroRNAs as Potential Biomarkers in Coronary Artery Disease
Authors: Bergami Maria , Fabin Natalia , Cenko Edina , Bugiardini Raffaele , Manfrini Olivia 
Published: December 2022

Abstract:Coronary artery disease (CAD) is the leading cause of mortality globally. Although sub-stantial advances have been made in the diagnosis, management, and risk stratification of CAD, there is still a need for novel diagnostic biomarkers and new therapeutic targets to prevent the epi-demic of the disease. Recently, growing evidence has linked dysregulated microRNAs (miRNAs) to cardiovascular diseases, including CAD. miRNAs are endogenous, stable, single-stranded, short, non-coding RNAs, and may have utility as diagnostic and prognostic biomarkers for CAD. Dysreg-ulated miRNAs are involved in regulating lipid and glucose homeostasis pathways, renin-angiotensin-aldosterone pathways, inflammation, endothelial and vascular smooth cell phenotypes promoting atherosclerotic plaque development, progression, and instability. Additionally, miRNAs are stable and easily accessible in the extracellular space, may reside in microvesicles, and are de-tectable in serum or plasma, making them attractive biomarkers for the diagnosis and prognosis of cardiovascular disease. Accumulating studies suggest that miRNAs could be useful biomarkers for early discrimination of patients presenting with myocarditis or Takotsubo syndrome from those with a diagnosis of acute myocardial infarction, early prognostication of patients presenting with acute coronary syndromes, and accurate detection of left ventricular remodeling after a chronic or acute ischemic event. Moreover, miRNAs represent potential novel therapeutic targets for CAD or other cardiovascular diseases. This review provides an overview of the effects of the entire spec-trum of CAD, its major risk factors, and complications on levels of circulating miRNAs, as well as the limitations and challenges of their potential clinical applications.
Implication of Hippocampal Neurogenesis in Autism Spectrum Disorder:
Pathogenesis and Therapeutic Implications
Authors: Liu Chuanqi , Liu Jiayin , Gong Hong , Liu Tianyao , Li Xin , Fan Xiaotang 
Published: December 2022

Abstract:
Autism spectrum disorder (ASD) is a cluster of heterogeneous neurodevelopmental conditions
with atypical social communication and repetitive sensory-motor behaviors. The formation of
new neurons from neural precursors in the hippocampus has been unequivocally demonstrated in the
dentate gyrus of rodents and non-human primates. Accumulating evidence sheds light on how the deficits
in the hippocampal neurogenesis may underlie some of the abnormal behavioral phenotypes in
ASD. In this review, we describe the current evidence concerning pre-clinical and clinical studies supporting
the significant role of hippocampal neurogenesis in ASD pathogenesis, discuss the possibility
of improving hippocampal neurogenesis as a new strategy for treating ASD, and highlight the prospect
of emerging pro‐neurogenic therapies for ASD.
The Anemic Newborn at Birth: From Diagnosis to Treatment
Authors: Perrone Serafina , Petrolini Chiara , Chiara Lembo , Chiara Brugnoli , Mario Staccioni , Buonocore Giuseppe 
Published: December 2022

Abstract:
Neonatal anaemia is a very frequent clinical condition that may be due to apparent or not evident blood loss, decreased red blood cells (RBCs) production, or increased destruction of RBCs. RBCs transfusion criteria are clearly defined by several national and locally agreed guidelines. However, it is not possible to define a unique cut-off to guide clinicians' transfusion practice, which needs a multiparametric analysis of demographic variables (gestational age, postnatal age, birth weight), clinical evaluation, conventional and new generation monitoring (such as echocardiog-raphy and near-infrared spectroscopy). Unfortunately, few tools are available in the delivery room to help neonatologists in the management of newborn with acute anaemia. Early volume replace-ment with cristalloids and RBCs transfusion could be life-saving in the delivery room when a hypovolaemic shock is suspected, but the use of un-crossmatched whole is not risk-free nor easily available in clinical practice. Placental transfusion could be an extremely effective and inexpensive method to increase haemoglobin (Hb), to improve oxygen delivery, and to increase cardiac output with a reduced need for RBCs transfusions, a reduced risk of intraventricular haemorrhages, and an improved survival of the newborn.
Effects and Mechanisms of Ban-Xia Xie-Xin Decoction on Type 2 Diabetes
Mellitus: Network Pharmacology Analysis and Experimental Evidence
Authors: Hu Zhipeng , Yang Maoyi , Zhang Lili , Yue Rensong 
Published: December 2022

Background:
Studies have indicated that Ban-Xia Xie-Xin Decoction (BXXXD) has
therapeutic effects on type 2 diabetes mellitus (T2DM). However, due to the complexity of components
and diversity of targets, the mechanisms are still not fully elucidated.

Objective:
In this research, we systematically analysed the targets of BXXXD through the method
of network pharmacology and further validated them through experiments.

Methods:
The active components and therapeutic targets were identified, and these targets were
analysed by the methods of gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes
(KEGG), and protein-protein interaction (PPI) analysis. Then, based on these network pharmacology
analyses, we validated the main targets through animal experiments.

Results:
A total of 169 active components and 159 targets were identified. KEGG analysis showed
that the mitogen-activated protein kinase (MAPK) signalling pathway, tumour necrosis factor
(TNF) signalling pathway, the phosphatidylinositol 3' -kinase (PI3K), Akt signalling pathway, and
other pathways were related to the treatment of T2DM by BXXXD. PPI network analysis showed
that the key genes included signal transducers and activators of transcription 3 (STAT3), JUN,
TNF, Recombinant V-Rel Reticuloendotheliosis Viral Oncogene Homolog A (RELA), Akt/PKB-
1 (Protein kinase B), TP53, mitogen-activated protein kinase-1 (MAPK-1), mitogen-activated protein
kinase-3 (MAPK-3), interleukin- 6 (IL6), and mitogen-activated protein kinase-14 (MAPK-
14), respectively. Animal experiments showed that BXXXD could reduce blood glucose and improve
insulin resistance, which may be related to the mechanisms of inhibiting TNF, interleukin-1
(IL-1), IL-6, and interleukin-17 (IL-17) and promoting Akt phosphorylation.

Conclusion:
Our research revealed the mechanisms of BXXXD in the treatment of diabetes, which
laid a solid foundation for further studies on the molecular mechanisms of BXXXD in the treatment
of T2DM.
Application of a Genetic Algorithm for the Optimal Calibration of Hysteretic Models
Authors: Di Benedetto Sabatino , Latour Massimo , Rizzano Gianvittorio 
Published: December 2022

Background:
Recent computing improvements have allowed a considerable use of numerical models to predict phenomena concerning various topics. In particular, considering the field of civil engineering, the possibility of having greater computational capabilities has guaranteed to explore both the global and local behaviour of buildings with greater attention and precision so that currently, many software programs allow modelling different structural components with high accuracy.

Objective:
One of the aspects of interest concerns the calibration of phenomenological laws to model the mechanical behaviour of specific structural members, devices or connections. With this in mind, many efforts have recently been dedicated to solving this problem by implementing computational codes called “Genetic Algorithms”, which provide optimal configurations of parameters following procedures that emulate Darwin’s theory of evolution. However, generally, these algorithms are encoded in C++ formats, which are difficult to be modified basing on the needs of the users.
With this in mind, the present work's novelty consists of implementing a Genetic Algorithm that, starting from the knowledge of assigned hysteretic curves, allows their modelling through an appropriate calibration of the parameters of the “hysteretic” uniaxialmaterial element of the OpenSees software. In particular, the originality of the code proposed in this paper is its development in the Matlab environment, which is more easily editable and more flexible to customers' specific needs than traditional C++ compilers, such as MultiCal, a calibration software already available in research.

Methods:
Genetic Algorithms are instructions through which it is possible to reach the optimal calibration of mathematical models according to a procedure that conceptually refers to the evolutionary process of living species.

Results:
The proposed GA has been validated against MultiCal tool by calibrating 44 force-displacement hysteretic curves obtained from finite element simulations relating to the cyclic behaviour of connections between circular hollow section profiles and passing-through plates subjected to displacement histories in the axial direction.

Conclusion:
The results have shown that the proposed algorithm calibrates the known responses with acceptable accuracy, in line with or even better than the outcomes provided by MultiCal.
Article 9 - EU FTAs and divided sovereignty: Transformative shifts in trade authority
Authors: Guimarães Maria Helena 
Published: December 2022

EU trade policy has evolved on the scope of its remit through what can be framed as “creeping competence” (Pollack 1994, 2000). Since the Treaty of Rome to the Lisbon Treaty the EU has consolidated its sovereignty over trade by broadening its competences. However, the enlarged scope of EU FTAs has pushed subnational units to demand shared sovereignty over trade issues to protect the status quo on their regulatory competences. In turn, the 2017 Court of Justice ruling that the EU-Singapore Agreement could only be concluded with the consent of the EU and its Member States has led the Commission to propose the splitting of trade deals into EU-only and “mixed” agreements. While the EU holds to its exclusive competences in the former, mixed agreements require divided sovereignty with the member states. Both the engagement of subnational entities in trade policy and the impact of the Court decision represent transformative shifts in the locus of trade policymaking from centralized competences to divided sovereignty with national and subnational entities. The ensuing difficulties in ratifying EU trade agreements have prompted stop-gap solutions that raise questions as to where the pattern of “creeping competence” is applicable. These political and legal challenges highlight that “creeping competence” may have unintended consequences unleashed by the dynamics of the policy itself. In trade policy the notion of “creeping competence” has to capture the legal challenges, the efforts to claw back centralization, as well as the pushback by subnational entities to protect their regulatory sovereignty.