bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of polyamide (NYLON) versus polymethyl methacrylate (PMMA) denture base materials regarding water solubility: in vitro research
Authors: Mostafa Marwa Hassan , AlSourori Ali Abdulghani 
Published: May 2023

Abstract
Background
Several denture base materials have evolved over the years. Beginning with metal and ending up with various types of acrylic materials in order to have a biocompatible, antimicrobial denture base. A flexible acrylic resin, such as Polyamides, has been introduced to address the drawbacks of heat-cured PMMA resin. This study was conducted to examine the water solubility and water sorption of flexible thermoplastic polyamides (Valplast) and two types of conventional heat-cured acrylic resin (PMMA) (Acrostone, Vertex).

Methods
Specimens of thermoplastic polyamides and two types of conventional PMMA (Acrostone, Vertex) resin were manufactured and used in the current investigation in accordance with manufacturer instructions. A total of 45 specimens were milled into discs with a diameter of 50.0 mm diameter, 5.0 mm thick. To ascertain conformity with ADA Standard No. 12, water solubility and water sorption were measured.

Results
All items complied with ADA regulations for water solubility and sorption. Flexible thermoplastic polyamide displayed less water solubility, and water sorption than heat-cured PMMA. Acrostone showed the higher water solubility, sorption followed by Vertex heat cure acrylic resin both heat cured showed significant higher water solubility than polyamides Valplast).

Conclusions
Within the limitations of this in vitro experiment, heat cure PMMA resin demonstrated significantly greater water solubility and water sorption when compared to thermoplastic polyamides.
Disclosures for slavery accounting concerning SDG 8 and corporate attributes: a study on the banking industry of Bangladesh
Authors: Saha Trina , Miah Rubel , Rahman Mahfujur , Das Sumon Kumar , Hoque Emranul 
Published: May 2023

AbstractWith the continuous adoption of sustainable development goals by all countries, there is a rising demand for implementing and disclosing related information by companies. This paper aims to find an idea about the nature of reporting practices related to slavery by listed banking companies of Bangladesh and the relationship between reporting practice and organizational attributes. Existing literature provides the foundation of this study. Annual reports from 2016 to 2021 were collected from the company websites, and content analysis was used to determine the nature and extent of slavery reporting; an index was developed based on content analysis. Independent variables were determined based on the current literature review. Statistical tools, including the test of multicollinearity, heteroscedastic, correlation, and linear regression and panel data analyses were used to determine the fitness of the model and the impact of independent variables on the dependent variable. Content analysis showed a clear picture of the consciousness about slavery accounting as all of the companies reported a minimum of three components of selected targets from SDG8. The evidence says that the quality and quantity of slavery reporting are improving yearly. A satisfactory correlation was found among the variables. Some variables, such as ownership nature, Board Size, etc., have a positive impact, and insignificant impact was found for Age and leverage on slavery disclosure. This paper only examines the banking industry, and it assesses only a few targets of SDG 8. Thus the results obtained from the study may not be similar to other companies. Data collection also has limitations; our target was to study till 2022 but some information requirements of few companies were not available on websites. This research paper is the first attempt to determine the nature of slavery accounting in Bangladesh. It will encourage business organizations to extend their reporting on slavery and SDGs.
Single-cell intracellular pH dynamics regulate the cell cycle by timing the G1 exit and G2 transition
Authors: Spear Julia S. , White Katharine A. 
Published: May 2023

ABSTRACT
Transient changes in intracellular pH (pHi) regulate normal cell behaviors, but roles for spatiotemporal pHi dynamics in single-cell behaviors remain unclear. Here, we mapped single-cell spatiotemporal pHi dynamics during mammalian cell cycle progression both with and without cell cycle synchronization. We found that single-cell pHi is dynamic throughout the cell cycle: pHi decreases at G1/S, increases in mid-S, decreases at late S, increases at G2/M and rapidly decreases during mitosis. Importantly, although pHi is highly dynamic in dividing cells, non-dividing cells have attenuated pHi dynamics. Using two independent pHi manipulation methods, we found that low pHi inhibits completion of S phase whereas high pHi promotes both S/G2 and G2/M transitions. Our data also suggest that low pHi cues G1 exit, with decreased pHi shortening G1 and increased pHi elongating G1. Furthermore, dynamic pHi is required for S phase timing, as high pHi elongates S phase and low pHi inhibits S/G2 transition. This work reveals that spatiotemporal pHi dynamics are necessary for cell cycle progression at multiple phase transitions in single human cells.
Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells
Authors: Wint Haymar , Li Jianzhen , Abe Tadashi , Yamada Hiroshi , Higaki Takumi , Nasu Yasutomo , Watanabe Masami , Takei Kohji , Takeda Tetsuya 
Published: May 2023

ABSTRACT
Collective cell migration is the coordinated movement of multiple cells connected by cadherin-based adherens junctions and is essential for physiological and pathological processes. Cadherins undergo dynamic intracellular trafficking, and their surface level is determined by a balance between endocytosis, recycling and degradation. However, the regulatory mechanism of cadherin turnover in collective cell migration remains elusive. In this study, we show that the Bin/amphiphysin/Rvs (BAR) domain protein pacsin 2 (protein kinase C and casein kinase substrate in neurons protein 2) plays an essential role in collective cell migration by regulating N-cadherin (also known as CDH2) endocytosis in human cancer cells. Pacsin 2-depleted cells formed cell–cell contacts enriched with N-cadherin and migrated in a directed manner. Furthermore, pacsin 2-depleted cells showed attenuated internalization of N-cadherin from the cell surface. Interestingly, GST pull-down assays demonstrated that the pacsin 2 SH3 domain binds to the cytoplasmic region of N-cadherin, and expression of an N-cadherin mutant defective in binding to pacsin 2 phenocopied pacsin 2 RNAi cells both in cell contact formation and N-cadherin endocytosis. These data support new insights into a novel endocytic route of N-cadherin in collective cell migration, highlighting pacsin 2 as a possible therapeutic target for cancer metastasis.
Adaptive modeling for security vulnerability propagation to predict the impact of business process redesign
Authors: Djunaidy Arif , Hariyanti Eva , Siahaan Daniel 
Published: May 2023

Background: Business process redesign (BPR) is typical in organizations and is followed by adaptive maintenance on supporting applications. However, BPR leads to information security vulnerabilities that can propagate to its supporting applications. Methods: This study proposes a new method called Node Strength-based Vulnerability Modeling (NSVM) for modeling security vulnerability propagation in the business processes and IT service layers. We applied the concept of social network strength to build our propagation model. The propagation model is needed to predict the impact of BPR on application vulnerabilities. We chose e-commerce applications as a case study. We evaluated the vulnerability propagation model by comparing the predicted vulnerability scores from the model with the actual scores of e-commerce applications in the National Vulnerability Database. Results: Our experimentation indicates that the propagation strength between nodes is influenced by Common Weakness Enumerations (CWEs) between them. Thus, the vulnerability propagation model can predict vulnerability scores at module nodes in the IT service layer. In the NSVM, the best prediction scores were obtained by aggregating the adjacency and initial scores using the maximum principle approach. The best evaluation results yield mean absolute error (MAE), root mean squared error (RMSE), and mean squared error (MSE) scores of 0.60, 1.44, and 1.16, respectively. Conclusion: Our study shows that the vulnerability propagation model with an adaptive mechanism based on BPR can be used to predict security vulnerability scores as the impact of business process redesign.
Cookies rich in iron (Fe), folic acid, cobalamin (vitamin B12), and antioxidants: a novel functional food potential for adolescent with anemia
Authors: Bolang Alexander Sam Leonard , Rizal Mochammad , Nurkolis Fahrul , Mayulu Nelly , Taslim Nurpudji Astuti , Radu Son , Samtiya Mrinal , Assa Youla Annatje , Herlambang Hendra Agung , Pondagitan Alpinia Shinta , Vivo Christopherous Diva 
Published: May 2023

Background: Anemia is a global public health problem, including Indonesia with 32% of adolescents are anemic. This study aims to process porang flour, moringa leaves, and tempe into cookies that are high in iron (Fe), folic acid, cobalamin (vitamin B12), and antioxidants as potential functional food snacks for adolescents with anemia. Methods: This study is experimental with a completely randomized trial design (CRD) with three treatments and replications. There are three comparison formulations of a combination of porang, moringa leaves, and black soybean-based tempe; respectively F1 (91:3:3:3)%, F2 (85:3:6:6)%, and F3 (77:3:10:10)%. The cookie sample was then analyzed for water content, ash, iron, folic acid, cobalt, and antioxidant activity. The differences between the samples were analyzed based on the activity of antioxidants, iron, folic acid, and vitamin B12 (cobalamin) in data obtained from triplicates using multivariate ANOVA analysis. Results: The results of the ash and water content tests of all three cookie formulations showed values in accordance with the Indonesian National Standard (SNI) for cookie products. F3 has significantly higher iron, folic acid, and cobalt levels than F1 and F2 (p<0.05). Antioxidant activity is highest in F3, but there is no statistical difference between F2 and F3 (p>0.05). Conclusions: The combination of porang's tubers, moringa leaves, and tempe made from black soybeans, especially F3, has the potential to be used as a functional cookie processed product source of iron (Fe), folic acid, cobalamin, and antioxidants for adolescent anemia.
Pilot of a person-centred, interdisciplinary approach to goal setting in Ireland’s National Rehabilitation Hospital: a study protocol
Authors: Christophers Lauren , Torok Zsofia , Cornall Catherine , Carroll Aine 
Published: May 2023

Background: Research has emphasized the value of a person-centered, interdisciplinary approach to structured goal setting in rehabilitation; yet these approaches are not consistently implemented in clinical practice, limiting the effect that goal setting can have on rehabilitation. The introduction of a new interdisciplinary, person-centered goal setting process to Ireland’s national rehabilitation hospital offers an opportunity to gain novel insight into barriers to implementing and normalising IDT goal setting in complex, specialist rehabilitation services. Methods: The goal setting process was collaboratively designed based on iterative rounds of patient and staff feedback. It will be piloted in three different units of the hospital. The outlined study was co-designed by embedded academic researchers and knowledge stakeholders (the quality improvement team responsible for introducing the new process; and two former patients). The aim is to use a mixed methods approach to capture patient and staff experiences and perspectives of the new process. Data will be collected by embedded researchers with a combination of self-report measures and qualitative interviews with both staff and patients. Self-report measures focus on capturing person centeredness of goals, shared decision making, interprofessional socialization and process normalization. Quantitative data will be represented using descriptive and inferential statistics; qualitative data will be analysed using reflexive thematic analysis. Discussion & Conclusion: From this data the researchers aim to present a holistic view of the patient and staff experiences of the goal setting process. This may further illuminate challenges and potential solutions to implementing changes to goal setting within this context. Findings will be used to inform implementation within the hospital and will contribute to knowledge for rehabilitation practice around implementing IDT goal setting. This will add an Irish perspective to existing goal setting rehabilitation literature.
Team based collaborative care model, facilitated by a mHealth enabled and trained nurse, for management of heart failure in India (TIME-HF): design and rationale of a parallel group, open label, multi-centric cluster randomized controlled trial
Authors: Jeemon Panniyammakal , Bahuleyan Charantharalyil Gopalan , Chandgalu Javaregowda Devaraju , Punnoose Eapen , Rajendiran Gopalan , Unni Govindan , Abdullakutty Jabir , Balakrishnan Jayakumar , Joseph Johny , Gnanaraj Justin Paul , Sreedharan Madhu , Pillai Meera R , KR Neenumol , Thomas Paul , Sebastian Placid , Daniel Rachel , Edakutty Rajeev , Ahmad Sajan , Mattummal Shafeeq , Thomas Sunu C , Joseph Stigi , Pisharody Sunil , Chacko Susanna , Syam N , Nair Tiny , Nanjappa Veena , Ganesan Vijayan , George Vijo , Ganapathi Sanjay , Harikrishnan Sivadasanpillai 
Published: May 2023

Background: Heart failure (HF) is a debilitating condition associated with enormous public health burden. Management of HF is complex as it requires care and coordination with different cadres of health care providers. In resource poor settings, physician driven initiatives to improve HF management is difficult due to multiple barriers. We propose to develop a team based collaborative care model (CCM), facilitated by a trained nurse, for management of HF with the support of mHealth and evaluate their acceptability and effectiveness in Indian setting. Methods: The proposed study will use mixed-methods research for assessment. A formative qualitative research will identify barriers and facilitators for implementing CCM for the management of HF and develop components of the intervention. Subsequently, a cluster randomised controlled trial (RCT) involving 22 centres (tertiary hospitals) with more than 1500 HF patients will be conducted to assess the effectiveness of the CCM in improving the overall survival as well as days alive and out of hospital (DAOH) at two-years (CTRI/2021/11/037797). The DAOH will be calculated by subtracting days in hospital and days from death until end of study follow-up from the total follow-up time. Poisson regression with a robust variance estimate and an offset term to account for clustering will be employed in the analyses of DAOH. A rate ratio and its 95% confidence interval (CI) will be estimated. The scalability of the proposed intervention model will be assessed through economic analyses (cost-effectiveness) and the acceptability of the intervention at both the provider and patient level will be understood through process evaluation. Potential Impact: The TIME-HF trial will provide evidence on whether a nurse-led team based CCM with mHealth support is effective in improving the clinical outcomes of HF in India. The findings may change the practice of management of HF in financially constrained low and middle-income countries.
Similar results after five years with the use of the Fitmore or the CLS femoral components
Authors: Rilby Karin , Mohaddes Maziar , Kärrholm Johan 
Published: May 2023

AimsAlthough the Fitmore Hip Stem has been on the market for almost 15 years, it is still not well documented in randomized controlled trials. This study compares the Fitmore stem with the CementLeSs (CLS) in several different clinical and radiological aspects. The hypothesis is that there will be no difference in outcome between stems.MethodsIn total, 44 patients with bilateral hip osteoarthritis were recruited from the outpatient clinic at a single tertiary orthopaedic centre. The patients were operated with bilateral one-stage total hip arthroplasty. The most painful hip was randomized to either Fitmore or CLS femoral component; the second hip was operated with the femoral component not used on the first side. Patients were evaluated at three and six months and at one, two, and five years postoperatively with patient-reported outcome measures, radiostereometric analysis, dual-energy X-ray absorptiometry, and conventional radiography. A total of 39 patients attended the follow-up visit at two years (primary outcome) and 35 patients at five years. The primary outcome was which hip the patient considered to have the best function at two years.ResultsAt two and five years, more patients considered the hip with the CLS femoral component as superior but without a statistically significant difference. There were no differences in clinical outcome, magnitude of femoral component migration, or change of bone mineral density at five years. At three months, the Fitmore femoral component had subsided a median -0.71 mm (interquartile range (IQR) -1.67 to -0.20) and the CLS femoral component -0.70 mm (IQR -1.53 to -0.17; p = 0.742). In both groups the femoral head centre had migrated posteriorly (Fitmore -0.17 mm (IQR -0.98 to -0.04) and CLS -0.23 mm (IQR -0.87 to 0.07; p = 0.936)). After three months neither of the femoral components showed much further migration. During the first postoperative year, one Fitmore femoral component was revised due to aseptic loosening.ConclusionUp to five years, we found no statistically significant difference in outcomes between the Fitmore and the CLS femoral components. The slightly worse outcomes, including one revised hip because of loosening, speaks against the hypothesis that the Fitmore femoral component should be advantageous compared to the CLS if more patients had been recruited to this study.Cite this article: Bone Jt Open 2023;4(5):306–314.
Prognostic factors for intraoperative detection of necrotizing fasciitis in severe soft tissue infections
Authors: Abdalla Thaer S. A. , Grotelüschen Rainer , Abdalla Ahmed S. A. , Melling Nathaniel , Izbicki Jakob R. , Bachmann Kai 
Published: May 2023

Background
Necrotizing fasciitis (NF) is a rare but lethal soft-tissue infection. There is still a paucity of information regarding the diagnostic tools and therapeutic strategies for the treatment of this devastating disease. This study aims to identify important perioperative parameters related to necrotizing fasciitis and to assess their relevance in terms of identifying NF.

Methods and material
We retrospectively analyzed patients who underwent surgical exploration for suspected necrotizing fasciitis at a tertiary referral center, to explore the clinical features and factors related to the presence of necrotizing fasciitis and mortality.

Results
Between 2010 and 2017, 88 patients underwent surgical exploration for suspected NF. The infection occurred in the lower extremities in 48 patients, in the thoracocervical region in 18 patients, and the perineum and abdomen in 22 patients. Histological evidence of NF was present in 59 of 88 patients. NF was associated with a longer hospital stay and ICU stay (p = 0.05 and 0.019 respectively) compared to patients without NF. ROC analysis showed that only macroscopic fascial appearance could discriminate patients with histological evidence of NF. Moreover, multivariate logistic regression revealed, that liver failure (p = 0.019), sepsis (p = 0.011), positive Gram stain (p = 0.032), and macroscopic fascial appearance (p <0.001) were independent prognostic parameters for histological evidence of NF.

Conclusion
Intraoperative tissue evaluation by an experienced surgeon is the most important diagnostic tool in identifying necrotizing fasciitis. An intraoperative Gram stain is an independent prognostic tool and therefore its use can be recommended especially in case of clinical uncertainty.
Community engagement initiatives in primary health care to achieve universal health coverage: A realist synthesis of scoping review
Authors: Erku Daniel , Khatri Resham , Endalamaw Aklilu , Wolka Eskinder , Nigatu Frehiwot , Zewdie Anteneh , Assefa Yibeltal 
Published: May 2023

Background
Community engagement (CE) is an essential component in a primary health care (PHC) and there have been growing calls for service providers to seek greater CE in the planning, design, delivery and evaluation of PHC services. This scoping review aimed to explore the underlying attributes, contexts and mechanisms in which community engagement initiatives contribute to improved PHC service delivery and the realisation of UHC.

Methods
PubMed, PsycINFO, CINAHL, Cochrane Library, EMBASE and Google Scholar were searched from the inception of each database until May 2022 for studies that described the structure, process, and outcomes of CE interventions implemented in PHC settings. We included qualitative and quantitative studies, process evaluations and systematic or scoping reviews. Data were extracted using a predefined extraction sheet, and the quality of reporting of included studies was assessed using the Mixed Methods Appraisal Tool. The Donabedian’s model for quality of healthcare was used to categorise attributes of CE into “structure”, “process” and “outcome”.

Results
Themes related to the structural aspects of CE initiatives included the methodological approaches (i.e., format and composition), levels of CE (i.e., extent, time, and timing of engagement) and the support processes and strategies (i.e., skills and capacity) that are put in place to enable both communities and service providers to undertake successful CE. Process aspects of CE initiatives discussed in the literature included: i) the role of the community in defining priorities and setting objectives for CE, ii) types and dynamics of the broad range of engagement approaches and activities, and iii) presence of an on-going communication and two-way information sharing. Key CE components and contextual factors that affected the impact of CE initiatives included the wider socio-economic context, power dynamics and representation of communities and their voices, and cultural and organisational issues.

Conclusions
Our review highlighted the potential role of CE initiatives in improving decision making process and improving overall health outcomes, and identified several organisational, cultural, political, and contextual factors that affect the success of CE initiatives in PHC settings. Awareness of and responding to the contextual factors will increase the chances of successful CE initiatives.
„Überwachen und Strafen“ – Tracking und Kontrolle des Forschungszyklus
Authors: Siems Renke 
Published: May 2023

Zusammenfassung
Seit dem Informationspapier der Deutschen Forschungsgemeinschaft aus dem Jahr 2021 wird das Thema Datentracking in der Wissenschaft viel diskutiert. Jedoch sind bislang weder umfassende Konzepte sichtbar, wie der damit einhergehenden Gefährdung der wissenschaftlichen Autonomie und Integrität beispielsweise durch die Stärkung digitaler Souveränität abgeholfen werden könnte, noch kommt der Griff der maßgeblichen wirtschaftlichen Akteure nach dem gesamten Forschungszyklus angemessen in den Blick. Dieser Aufsatz betrachtet die wissenschaftlichen Workflows und deren Unterminierung durch datenbasierte Geschäftsmodelle.