bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fiducial markers in adjuvant setting for a patient affected by endometrial cancer: a case report
Authors: Titone Francesca , Restaino Stefano , Moretti Eugenia , Vullo Gianluca , Poli Alice , Arcieri Martina , Paglietti Chiara , Tonetto Fabrizio , Parisi Giuseppe , Barbui Elisa , Trovò Marco , Scambia Giovanni , Driul Lorenza , Vizzielli Giuseppe 
Published: August 2023

IntroductionIntermediate-high and high-risk endometrial cancer often require adjuvant treatments such as radiotherapy (RT) or brachitherapy (BT) to reduce the risk of loco-regional relapse. Inter- and intra-fraction variability of internal pelvic anatomy are possibly the largest source of error affecting pelvic RT. The implantation of Fiducial Makers (FMs) in the vaginal cuff of patients receiving RT or BT could help patient daily setup, image guidance and intra-fraction detection of the radiation targets.Clinical caseWe have evaluated the case of an 80-year-old woman treated with surgery for endometrioid adenocarcinoma G2 (stage pT1b Nx LVSI+) who underwent adjuvant pelvic IMRT after the implantation of vaginal cuff FMs.CT-simulation, Treatment Planning and IGRT strategyPatient underwent planning CT scan 10 days after FMs implantation. RT consisted of 45Gy in 25 daily fractions to pelvic lymph nodes and surgical bed with simultaneous integrated boost up to 52.5Gy to the vaginal cuff and the upper two-thirds of the vagina. Cone beam Computed Tomography (CBCT) was acquired prior to every RT fraction for IGRT. Bladder and rectum were re-contoured on every CBCTs. Bladder and rectal volumes and median shifts were reported on a prospective database to quantify the impact of the pelvic organ variations.ResultsThe patient reported no discomfort during the FMs implantation, and no complications were seen. No evidence of FMs migration was reported. Bladder and rectal volumes planned contours were 245 and 55.3cc. Median bladder volumes for approved and “not acceptable” CBCTs were 222cc (range: 130-398) and 131cc (range: 65-326), respectively. Median rectal volumes for approved and “not acceptable” CBCTs were 75cc (range: 58-117) and 90cc (range: 54-189), respectively. The median values of the anterior-posterior, superior-inferior, lateral direction shifts were 3.4, 1.8 and 2.11 mm, respectively.ConclusionIn our clinical case, the implantation of FMs in the vaginal cuff of a patient who underwent pelvic adjuvant RT was well tolerated and reported no complications. The use of IGRT procedures based on FMs surrogating the vaginal vault may reduce inter-observer variability and pave the way for adaptive strategies or stereotactic treatments as external beam pelvic boost in gynecological field.
A bibliometric analysis of metastatic breast cancer: two-decade report (2002-2022)
Authors: Jiang Siyuan , Meng Qingjie , Ji Fuqing , Yin Yulong , Liu Xianghua , Shi Wenzhen , Lyu Yonggang 
Published: August 2023

BackgroundMBC is a lethal form of breast cancer that arises when cancer cells invade other organs or tissues. The treatment of MBC needs personalized approaches based on the tumor and patient characteristics. The purpose of this paper is to analyze MBC studies from 2002 to 2022 using bibliometrics and to investigate its current situation, main contributors, core journals, highly cited papers, and topic evolution.Materials and methodsWe retrieved data from Web of Science Core Collection (WOSCC). Bibliometric analysis of the included literatures mainly used the following tools: the function of “analyze results” and “citation report” in WoS, Microsoft excel 2021, CiteSpace v.6.1. R6, VOSviewer v.1.6.18, BICOMB v.2.04 and gCLUTO v.1.0.ResultsWe found 12,653 articles on MBC research published in 1, 802 journals by 69, 753 authors from 118 countries. The annual output and citation of MBC articles showed a rising trend over time. The United States was the most influential country in MBC research. The most cited journal in this field was The Journal of Clinical Oncology. And the most cited article was by Slamon DJ. The co-word analysis of keywords divides MBC into six research clusters. The hormone receptor-positive MBC and liquid biopsy of MBC are the frontiers research trends. “CDK4/6 inhibitor” had the highest burst strength.ConclusionOur bibliometric analysis offers a comprehensive overview of MBC research in the past two decades. It shows the current situation, main contributors, core journals, highly cited papers, and topic evolution of this field. Our study can assist researchers and practitioners to comprehend the development and trends of MBC research and to discover potential directions for future research.
Economic evaluations of artificial intelligence-based healthcare interventions: a systematic literature review of best practices in their conduct and reporting
Authors: Vithlani Jai , Hawksworth Claire , Elvidge Jamie , Ayiku Lynda , Dawoud Dalia 
Published: August 2023

Objectives: Health economic evaluations (HEEs) help healthcare decision makers understand the value of new technologies. Artificial intelligence (AI) is increasingly being used in healthcare interventions. We sought to review the conduct and reporting of published HEEs for AI-based health interventions.Methods: We conducted a systematic literature review with a 15-month search window (April 2021 to June 2022) on 17th June 2022 to identify HEEs of AI health interventions and update a previous review. Records were identified from 3 databases (Medline, Embase, and Cochrane Central). Two reviewers screened papers against predefined study selection criteria. Data were extracted from included studies using prespecified data extraction tables. Included studies were quality assessed using the National Institute for Health and Care Excellence (NICE) checklist. Results were synthesized narratively.Results: A total of 21 studies were included. The most common type of AI intervention was automated image analysis (9/21, 43%) mainly used for screening or diagnosis in general medicine and oncology. Nearly all were cost-utility (10/21, 48%) or cost-effectiveness analyses (8/21, 38%) that took a healthcare system or payer perspective. Decision-analytic models were used in 16/21 (76%) studies, mostly Markov models and decision trees. Three (3/16, 19%) used a short-term decision tree followed by a longer-term Markov component. Thirteen studies (13/21, 62%) reported the AI intervention to be cost effective or dominant. Limitations tended to result from the input data, authorship conflicts of interest, and a lack of transparent reporting, especially regarding the AI nature of the intervention.Conclusion: Published HEEs of AI-based health interventions are rapidly increasing in number. Despite the potentially innovative nature of AI, most have used traditional methods like Markov models or decision trees. Most attempted to assess the impact on quality of life to present the cost per QALY gained. However, studies have not been comprehensively reported. Specific reporting standards for the economic evaluation of AI interventions would help improve transparency and promote their usefulness for decision making. This is fundamental for reimbursement decisions, which in turn will generate the necessary data to develop flexible models better suited to capturing the potentially dynamic nature of AI interventions.
Physical activity and cognitive function in middle-aged adults: a cross-sectional analysis of the PATH through life study
Authors: Quinlan Clare , Rattray Ben , Pryor Disa , Northey Joseph M. , Cherbuin Nicolas 
Published: August 2023

ObjectivesInvestigate the independent associations of objectively measured or self-reported physical activity at different intensities with cognitive performance in middle-aged adults.DesignCross-sectional.Methods156 middle-aged adults (age: 40.6 ± 1.5, 58.3% female) participated in the physical activity sub-study of the Personality and Total Health through life (PATH) project. Physical activity was measured objectively with the SenseWear™ armband (SWA), worn for seven consecutive days, and measured via self-report with a Physical Activity Recall survey (PAR). Cognitive performance was assessed with the Symbol Digit Modalities Test, the Digit Span Backwards, and an Immediate and Delayed Recall task. Associations between physical activity intensity and cognitive function were investigated in general linear models, controlling for age, sex, and education.ResultsNeither objectively measured nor self-reported physical activity were associated with cognitive function at light-, moderate-, vigorous-, or combined moderate-to-vigorous intensity in this cohort of well educated, healthy middle-aged adults. Sensitivity analyses with additional moderators (e.g., body mass index, hypertension, alcohol intake) and the use of composite cognitive measures did not alter the results.ConclusionIn this cohort of middle-aged adults, objectively measured and self-reported physical activity do not appear to be associated with cognitive function. Longitudinal follow-ups utilising objective physical activity measures may be important in determining the impact of mid-life behaviours on the trajectory of cognitive changes into older age.
Development and validation of a scale for streaming dependence (SDS) of online games in a Peruvian population
Authors: Sairitupa-Sanchez Liset Z. , Collantes-Vargas Alejandra , Rivera-Lozada Oriana , Morales-García Wilter C. 
Published: August 2023

BackgroundAddiction to online video game streaming has become one of the most appealing ways to occupy leisure time and is one of the most popular activities. The satisfaction it provides and the time invested in it are two of the main reasons why it is preferred. However, despite the clear benefits that this activity offers, in some cases, excessive use can lead to personal and/or family problems or abuse.ObjectiveThe objective of the study was to develop and validate a scale to measure potential traits of dependence on online game streaming. The participants were 423 Peruvian adults aged between 18 and 47 years (M = 22.87, SD = 5.02). The Streaming Dependence Scale (SDS) was developed based on a literature review, and exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted.ResultsThe scale showed adequate internal consistency (α, CR, ω, and H &gt; 80). Confirmatory analysis confirmed the one-dimensional structure (χ2 = 10.250, df = 5; p = 0.068; CFI = 0.98, TLI = 0.96, RMSEA = 0.06, SRMR = 0.05).ConclusionThe brief SDS is a valid and reliable measure that can be used as a useful tool to identify and evaluate streaming dependence.
Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
Authors: Vilalta-Lacarra Anna , Vilalta-Franch Joan , Serrano-Sarbosa Domènec , Martí-Lluch Ruth , Marrugat Jaume , Garre-Olmo Josep 
Published: August 2023

ObjectiveThis study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort.MethodsA community-based sample recruited in 1995, 2000, and 2005 aged between 35 and 75 years was examined in two waves and followed for a median of 6.7 years. SDS and C-EDS phenotypes were assessed using the Patient Health Questionnaire-9. Medication used by participants was collected. Deaths and their causes were registered during follow-up. Cox proportional hazard models stratified by sex were performed to determine the association between depressive phenotypes and mortality.ResultsThe cohort consisted of 5,646 individuals (53.9% women) with a mean age of 64 years (SD = 11.89). During the follow-up, 392 deaths were recorded, of which 27.8% were due to cancer. C-EDS phenotype was associated with an increased risk of cancer mortality in both men (HR = 2.23; 95% CI = 1.11–4.44) and women (HR = 3.69; 95% CI = 1.69–8.09), and SDS was significantly associated with non-cancer mortality in men (HR = 2.16; 95 CI % = 1.46–3.18). Selective serotonin reuptake inhibitors (SSRIs) were significantly associated with both cancer (HR = 2.78; 95% CI = 1.10–6.98) and non-cancer mortality (HR = 2.94; 95% CI = 1.76–4.90) only in the male population.ConclusionC-EDS phenotype was related to an increased risk of cancer mortality at 6 years. In addition, the use of SSRIs in the male population was associated with cancer and all-cause mortality.
What happened to parents’ views of school success for autistic children during the COVID-19 pandemic?
Authors: Cheng Sheng-Li , Cheng Sanyin , Liu Shushan , Li Yun 
Published: August 2023

BackgroundThe educational views of parents with autistic children directly impacts their children’s academic success. However, little research has been done on how the COVID-19 pandemic impacted parents’ academic and social views.AimThis study analyzes parents’ views of school success for their autistic children in the context of the COVID-19 pandemic and examines the relationships among pandemic stress, parental involvement, and parents’ views of school success for autistic children in mainland China.MethodsIn this study, 713 parents of autistic children completed measures assessing their pandemic stress, parental involvement, and views of school success; linear regression and structural equation modeling were used to analyze the data.ResultsParents’ views of school success were influenced by factors such as parents’ level of education, household income, parents’ gender, and children’s age. The effects of pandemic stress on views of school success for parents of autistic children are complex: physical and mental reaction has a negative direct effect on views of school success, a positive indirect effect mediated by parental involvement, and a net positive effect; risk perception and concern has a negative indirect effect; and both the direct and indirect effects of pragmatic hopefulness are positive. Education policymakers and practitioners need to seriously and carefully assess these results’ implications for modern, inclusive education.
Sleep, internalizing symptoms, and health-related quality of life in children with neurodevelopmental disorders: a cross-sectional analysis of cohort data from three research programs in Canada
Authors: McPhee Patrick G. , Georgiades Stelios , Andrade Andrea , Corkum Penny V. , Vaccarino Anthony L. , Cheema Heena , Chepesiuk Rachel , Iaboni Alana , Gorter Jan Willem ,   The OBI Cross-integrated Discovery Program Sleep Team
Published: August 2023

ObjectiveThe objectives of this study were to determine rates of sleep disturbances in children with neurodevelopmental disorders (NDDs) within and across disorders and compared to typically developing (TD) children and to describe differences above and below the clinical cut-off for sleep disturbances. In addition, we explored the associations between demographic variables, severity of disorder, sleep disturbances, internalizing symptoms, and health-related quality of life (HRQOL) in children with NDDs.MethodWe conducted cross-sectional data analyses of an existing database with community-dwelling children with NDDs (n = 1438) and TD children (n = 140) aged 4–12 years. Parent-reported measures on sleep disturbances using the Children's Sleep Habits Questionnaire (CSHQ), internalizing symptoms using the Revised Children's Anxiety and Depression Scale, and HRQOL using the KINDL-R were assessed. Hierarchical linear regression examined the associations between demographic variables, severity of disorder, sleep disturbances, internalizing symptoms, and HRQOL in children with NDDs.ResultsChildren with NDDs (8.5 ± 2.1 years, 69.9% M) had significantly greater total sleep disturbance index (TSDI) than TD children [(8.6 ± 2.3 years, 60.0% M) (mean difference = 6.88 [95% CI 5.37, 8.40]; p &lt; 0.001) (n = 838 NDDs (58.3%); n = 120 TD (86.7%)]. Children with severe NDDs reported significantly greater TSDI above the clinical cut-off (i.e., ≥41; CSHQ) than those with less severe NDDs (p &lt; 0.001). Internalizing symptoms (β = −0.082 [95% CI −0.144, −0.019]; p = 0.011) and TSDI (β = −0.226 [95% CI −0.380, −0.073]; p = 0.004) were significantly associated with HRQOL in children with NDDs.ConclusionSurveillance and management of sleep and internalizing symptoms are needed to improve HRQOL in children with NDDs. Commonalities in sleep disturbances for children with NDDs support transdiagnostic interventions to treat sleep.
Prolonged warm ischemia time increases mitogen-activated protein kinase activity and decreases perfusate cytokine levels in ex vivo rat liver machine perfusion
Authors: Kim Joohyun , Hong Seung-Keun , Yang Yongqiang , Lee Alice , Hoffmeister Karin M. , Gantner Benjamin N. , Park Jong-In 
Published: August 2023

IntroductionMachine perfusion is increasingly being utilized in liver transplantation in lieu of traditional cold static organ preservation. Nevertheless, better understanding of the molecular mechanisms underlying the ischemia-reperfusion injury (IRI) during ex vivo perfusion is necessary to improve the viability of liver grafts after transplantation using machine perfusion technology. Since key cellular signaling pathways involved in hepatic IRI may allow a chance for designing a promising approach to improve the clinical outcomes from this technology, we determined how warm ischemia time (WIT) during procurement affects the activity of mitogen-activated protein kinase (MAPK) and perfusate concentration of cytokines in an ex vivo rat liver machine perfusion model.MethodsMale Sprague-Dawley rats underwent in situ hepatic ischemia with varying WIT (0, 10, 20, 30 min, n = 5 each), and subsequently 3 h of cold ischemia time and 2 h of machine perfusion prior to determining the degree of MAPK activation-phosphorylation and cytokine concentration in liver tissue and perfusates, respectively.ResultsOur data revealed a strong correlation between incremental WIT and a series of liver injury markers, and that prolonged WIT increases ERK1/2 and p54 JNK phosphorylation during machine perfusion. Notably, specific cytokine levels (MCP-1, MIP-2, GRO/KC, IL-10, and IL-5) were inversely correlated with the phosphorylation levels of ERK1/2, p38 MAPK, and p46/p54 JNK.DiscussionThese results suggest that MAPK activation, specifically ERK1/2 and p54 JNK phosphorylation, have potential as a biomarker for hepatic IRI pathophysiology during machine perfusion. Elucidation of their functional significance may lead to designing a novel strategy to increase the clinical benefit of machine perfusion.
Age, Growth, and Reproductive Biology of Euchiloglanis davidi in the Middle and Lower Yalong River, China
Authors: Chen Jie , Zhu Xiangyun , Yang Xin , Hu Xianqin , Lin Pengcheng , Xu Bin , Wei Kaijin , Ma Baoshan 
Published: August 2023

In the present study, we investigated the age, growth, and reproductive characteristics of Euchiloglanis davidi, a species of Sisoridae fishes, from the Yalong River, China. Fish samples were collected from the tributaries of the middle and lower Yalong River in May 2013 and December 2015. Their standard length ranged from 67 to 190 mm, and the total weight ranged from 3.42 to 75.06 g. The age and growth pattern of E. davidi were determined using the vertebra. Furthermore, the sampled fish were categorized into 10 age groups (1–10 years old): the maximum age was 10 years and 9 years for male and female fish, respectively. The relationship between the standard length and weight was expressed as W = 6.744 × 10−5 L2.653, and the t-test showed allometric growth. The growth of E. davidi was defined by the von Bertalanffy growth function, described as Lt = 260.8(1−e−0.104(t+1.942)), Wt = 173.5(1−e−0.104(t+1.942))2.653, respectively. The growth inflection point was observed at 7.44 years, with corresponding length and weight values of 162.50 mm and 49.46 g. The fecundity ranged from 105 to 352 eggs, with an average of 205 eggs. The relative fecundity of weight (FW) ranged from 2.90 to 8.98 eggs/g, and the relative fecundity of length (FL) ranged from 0.71 to 2.11 eggs/mm. Altogether, these characteristics of slow growth and low fecundity demonstrated the vulnerability of E. davidi to exploitation in the middle and lower reaches of the Yalong River.
قنوات التنشئة الاجتماعية وأثرها في تشكيل شخصية الطالب الجامعي دراسة ميدانية في جامعة الفرات الاوسط التقنية
Authors: الموسوي الباحث المدرس حارث 
Published: August 2023

تضمن البحث الموسوم قنوات التنشئة الاجتماعية واثرها في تشكيل شخصية الطالب الجامعي دراسة ميدانية في جامعة الفرات الاوسط التقنية خمسة مباحث اساسية ثلاثة منها نظرية واثنان منها ميدانية او عملية فبعد كتابة آية من الذكر الحكيم ثم الاهداء الذي ذهب الى شهداء العراق كان هناك اطار البحث العام الذي تضمن مستخلص البحث والمقدمة ثم اهداف البحث واهمية البحث ومشكلة البحث في حين كان هناك المبحث الاول والذي اهتم بدراسة وتعريف المفاهيم الاساسية الخاصة بالبحث وكانت على النحو الاتي .
قنوات التنشئة الاجتماعية الشخصية ثم عملية التأثير واخيرا الطالب الجامعي وكان هناك ايضا المبحث الثاني والذي وضع نظره عامة على بعض قنوات التنشئة الاجتماعية كما قدم موجز عن النظام التربوي في العراق , اما المبحث الثالث فقد اهتم بدراسة تشكيل شخصية الطالب الجامعي بفعل بعض قنوات التنشئة الاجتماعية والتي هي الاسرة ووسائل الاتصال والاعلام ( الموبايل , والتلفزيون ) واخيرا المؤسسة الدينية بعدها بدأ الجانب الميداني والذي هو المبحث الرابع وضع اولا منهج وفرضيات البحث ثم مجالات البحث الزمانية والمكانية والبشرية ثم تصميم العينة ثم وسائل جمع البيانات وفي مقدمتها الاستبيان الذي تم توزيعه على المعهد التقني الكوفة والكلية التقنية الهندسية في النجف والمعهد التقني نجف بعدها المبحث الخامس الذي تضمن استعراض بعض النتائج والتوصيات الخاصة بالبحث وأخيرا كانت الخاتمة والذي تمثل رؤية الباحث لهذا الموضوع وكانت النهاية مع المصادر والمراجع التي استخدمها الباحث في كتابة بحثه المتقدم .
Health Economic Analysis of Two-Layer Bandage System for Treatment of Chronic Venous Insufficiency
Authors: Mallow Peter J. 
Published: August 2023

Background: Compression therapy is the gold standard for the treatment of chronic venous insufficiency (CVI). Two-layer bandage (2LB) systems have been shown to be a safe and effective treatment option. Objective: To estimate the total cost per response (CPR) for the resolution of edema and wounds in patients with CVI treated with a 2LB system as part of their overall wound healing regimen. Methods: A probabilistic decision tree model was developed to estimate the incremental CPR for a 2LB system. The model simulated 10 000 patients to estimate the CPR for the resolution of edema and wound healing. The analysis was performed using clinical data from a published single-arm, multicenter prospective study of CVI indicated for compression therapy. The response outcomes of interest were resolution of edema and rate of wound healing. The follow-up time was a maximum of 6 weeks, and the perspective of the study was a US outpatient treatment center. Economic data for compression therapy were based on the public prices of a 2LB system. Dressing changes occurred per manufacturer instructions for use. Results: The study comprised 702 patients (56% female), with a total of 414 wounds. The median duration of the wounds was 42 days, and the median size at the initial visit was 3.5 cm2. The average pain reduction fell by 67% using a visual analog score. Bandages were typically changed once or twice a week (51.7%). Wound healing occurred in 128 of the 414 wounds (30.9%). The expected incremental CPR of a 2LB system for the resolution of edema was $65.67 (range, $16.67-$124.32). The expected incremental CPR of a 2LB system for the healing of a wound was $138.71 (range, $35.71-$273.53). Conclusion: This economic evaluation complements previous clinical effectiveness and safety studies of 2LB systems for the treatment of CVI. The results demonstrate that the costs of incorporating 2LB into standard wound-healing protocols are negligible compared with overall treatment costs. Two-layer bandages may be considered a cost-effective first-line system for the treatment of wounds caused by CVI.