bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manajemen Kurikulum Berbasis Pesantren (Studi Kasus di Madrasah Tsanawiyah Darul Huda Mayak Tonatan Ponorogo)
Authors: Mahmudah Nisaul , Thoyib Muhammad , Sugiyar  
Published: July 2023

Kasus kriminal yang dilakukan oleh pelajar bukan lagi menjadi hal yang asing diberitakan. Hal tersebut menjadi salah satu indikasi menurunnya tingkat penghayatan masyarakat terhadap nilai-nilai pendidikan berbasis karakter. Solusinya adalah dengan menerapkan kurikulum pendidikan nasional yang dipadukan dengan nilai dan kultur pesantren. Tujuan penelitian ini adalah untuk menjelaskan, mendeskripsikan dan menganalisis perencanaan dan pengorganisasian, pelaksanaan, dan evaluasi kurikulum berbasis pesantren di Madrasah Tsanawiyah Darul Huda Mayak. Peneliti menggunakan jenis pendekatan kualitatif dengan studi kasus tunggal. Untuk menganalisis data penelitian, model Matthew B.Miles, A.Michael Huberman, dan Saldana merupakan metode analisis yang penulis gunakan sebagai acuan. Hasil penelitian ini menunjukkan bahwa: 1) Perencanaan kurikulum berbasis pesantren di MTs Darul Huda Mayak dilakukan dengan menentukan tujuan pembelajaran, penyesuaian antara kalender pendidikan nasional dengan kalender agenda yayasan. Adapun untuk pengorganisasian kurikulum dilakukan dengan merancang agar materi yang diterima siswa di sekolah relevan dengan materi pesantren. 2) Pelaksanaan kurikulum berbasis pesantren dilakukan dengan menerapkan K-13 dan KMA 183/184 dengan penyesuaian terhadap kurikulum dan kultur pesantren. 3) Evaluasi kurikulum berbasis pesantren dilakukan dengan beberapa tahapan. Pertama yakni evaluasi kegiatan pembelajaran yang dilaksanakan secara berkala, evaluasi materi dan kegiatan pembelajaran pada rapat MGMP, evaluasi sarana dan prasarana, serta evaluasi hasil pembelajaran pada setiap akhir semester.
Fossil Fuel Communities Support Climate Policy Coupled with Compensation
Authors: Gazmararian Alexander F. 
Published: July 2023

Abstract
How does the design of climate policy influence its support in fossil fuel communities? This study conducted survey experiments at Appalachian county fairs to answer this question, overcoming barriers that have limited previous attempts to measure preferences in these crucial regions. Comparing the responses to a new national survey, there is a divergence in preferences for place-based policies, but there is convergence behind support for policies that reduce costs to fossil fuel workers. The study also finds that an intervention to provide information about coal’s decline shifts preferences toward supporting the clean energy transition. Rather than public opinion being an immutable barrier to climate action, a majority (66%) of fossil fuel community residents would endorse climate policy if it were coupled with compensation. Policy design and informational interventions could help to build climate coalitions, even in the places most affected by the energy transition.
Photometric Search for variable stars in the field of two Northern open clusters, DOLIDGE 14 and NGC 1960
Authors: Joshi Gireesh C. 
Published: July 2023

Abstract
The aim of present work is extract and analyses the light curves of the stars in the fields of two clusters, NGC 1960 and DOLIDZE 14. The photometric extraction is performed by comprehensive methodology of SSM via standard transformation and differential photometry using two comparison stars per candidate variable target. The resultant light curves for each possible variable star are displayed and their period analysis are performed via two different methods. The period and classification of 18 discovered short periodic type variable stars of NGC 1960 are discussed, which consist of four known variable stars and fourteen new variable stars. In the case of DOLIDZE 14, four discovered variables consist of one miscellaneous, one rotational, two binary type variable stars. In the case of NGC 1960, the 12 selected comparison stars seems to be possible candidate for long periodic variability and 4 stars may be standard stars. The variation in brightness of other twenty comparison stars is non-pulsating with irregular pattern. Membership analysis of variable stars are performed by using their distance, kinematic probability and location in (U−B) vs (B−V ) TCD. C-M diagrams were constructed to confirm the evolutionary state of the new variable stars.
Data Mining Method in Seismology by Applying Cellular Automaton Equivalence of Ground Vibration Fluctuations Recorded Near the Epicenter of the 2011 Mw 9 East Japan Earthquake
Authors: Kikuchi Hiroyuki 
Published: July 2023

Abstract
We propose a data mining method to extract physical phenomena from the ground vibration velocity fluctuation (GVF) which is a daily observed weak signal and has no specific waveform. Our aim is to detect any traces of the return of ground motion to its normal state after earthquakes, and the evolution of ground motion towards earthquakes in the GVF. We focus on the GVF recorded near the epicenter of the magnitude 9 Great East Japan Earthquake (GEJE). Although the GVF can be discussed in the framework of the master equation which represents the thermodynamics of a stochastically fluctuating non-equilibrium system, the relation between the thermodynamic parameters and seismology-related phenomena is hardly known. So, we introduce cellular automata (CA) to analogically interpret the physical phenomena of interest as thermodynamic parameters, and show the thermodynamic equivalence between GVF and CA. These CA-derived thermodynamic parameters are then expected to deliver physical phenomena similar to those of the target when evaluated on the GVF data. In the demonstrated example of data mining, the stress relaxation signal immediately after GEJE is discovered from the recorded GVF data by deriving the thermodynamic parameters representing the stress relaxation of CA and evaluating these thermodynamic parameters for the recorded GVF data. Furthermore, the elastic rigidity and viscosity of the underground structures are estimated from the stress relaxation signal. The novelty of this study lies in drawing attention to the GVF, and combining standard techniques of CA with GVF through the use of the master equation.
Anatomical and Functional Outcomes after Endoresection and Adjuvant Ruthenium Brachytherapy for Uveal Melanoma: A Single-Center Experience
Authors: Mazzini Cinzia , Vicini Giulio , Leo Laura Di , Massi Daniela , Rizzo Stanislao , Giansanti Fabrizio 
Published: July 2023

Abstract
Purpose: To evaluate the anatomical and functional outcomes of endoresection and adjuvant ruthenium (Ru)-106 brachytherapy for uveal melanoma (UM).
Methods: Retrospective case series of 15 UM patients (15 eyes) treated at our center (Careggi University Hospital, Florence).
Results: Six patients (40%) were male and nine were female (60%). The mean age of patients at the time of treatment was 61.6 years (±18.47). The mean BCVA at baseline was 20/76. In all cases UM originated from the choroid. The mean tumor thickness at baseline was 7.20 mm (±2.01), and the mean largest basal diameter was 11.24 mm (±2.20). A concurrent retinal detachment was diagnosed in 11 patients (73.3%). Two patients (13.3%) showed vitreous seeding at baseline. Eleven patients (73.3%) were treated with primary endoresection, while four patients (26.7%) were treated with a “salvage endoresection” after primary treatment failure (previous radiation treatment). The mean follow-up time was 29.9 months (±10.6). Thirteen out of fifteen patients were alive and showed no evidence of local recurrence or distance metastasis at the last follow-up visit. The treatment achieved local control of the disease in 14 out of 15 cases (93.3%). In one case, the patient underwent enucleation for disease recurrence. The overall survival rate at the end of the follow-up was 93.3%. The mean BCVA at last follow-up visit was 20/70. Treatment was well tolerated, without significant complications.
Conclusions: Endoresection and adjuvant Ru-106 brachytherapy is a valuable conservative option for selected UM patients and can be used both as a primary treatment and as a salvage therapy. It can control melanoma and avoid enucleation, reduce radiation-related complications, and provide tumor tissue for chromosomal analysis and prognostic testing.
Recurrence or progression of neuroblastoma in children with MYCN amplification, 1p deletion or 11q deletion may due to altered immune status
Authors: Wei Zixuan , Gong Baocheng , Li Jie , Jin Yan , Cao Yanna , Yan Jie , Li Xin , Chen Chong , Zhao Qiang 
Published: July 2023

Abstract
Background
Neuroblastoma (NB) is a childhood malignancy originating from the sympathetic nervous system and is the most common extracranial malignant solid tumor in children. This study explored the prognosis of neuroblastoma patients with different genetic alterations, as well as altered peripheral blood immune status.
Methods
We screened 31 samples of neuroblastoma for MYCN amplification status and loss of heterozygosity at chromosome bands 1p36 and 11q23. Peripheral blood samples from these NB patients were tested for immune cells and cytokines by flow cytometry. Tests of association were performed with the use of Fisher’s exact test. Significant differences were analyzed using independent samples T-test. Survival curves were constructed according to the methods of Kaplan and Meier.
Results
According to FISH of pathological specimens, there were 6 patients with amplification of MYCN, 9 patients with chromosome 1p deletion, and 14 patients with chromosome 11q deletion. The event-free survival (EFS) was found to be worse in patients with MYCN amplification or 1p deletion than in the corresponding normal group by Kaplan-Meier analysis, whereas 11q deletion was a prognostic factor affecting EFS only in patients with unamplified MYCN. Changes in peripheral blood immune cells and cytokines detected by flow cytometry revealed a decrease in the proportion of tumor-infiltrating T cells (CD4 + and CD8 + T cells), an increase in regulatory T cells (Tregs), and an increase in immunosuppression-related factors interleukin (IL)-6 and IL-10.
Conclusions
In our analysis, NB with these genetic characteristics may have some regulatory network/signaling pathway to downregulate tumor-infiltrating T cells, upregulate suppressor cells such as Tregs, and promote the secretion of immunosuppressive cytokines IL-6 and IL-10, creating an immunosuppressive microenvironment that affects the immune response of patients and ultimately leads to a worse prognosis.
Effects of drought stress on seed germination and early seeding growth in Ferula ferulaeoides (Steud.) Korov.
Authors: Ma Ying , Liao Kai , Zhu Yun , Liu Shuang shuang , Zhao Yuan yuan , Lu Xin , Wang Kuan 
Published: July 2023

Abstract
Ferula ferulaeoides (Steud.) Korov. is a well-known perennial herb whose growth and distribution are negatively affected by drought. However, the seed germination stage and early seedling growth stage, which may be more sensitive to drought, have not been studied in detail. To reveal the effects of drought on seeds and seedlings of F. ferulaeoides, five water stress conditions induced by PEG-6000 treatment at five different concentrations (0, 5%, 10%, 15%, and 20%) were developed, in a completely randomized order for seeds and seedlings. The results revealed that drought stress significantly reduced seed germination percentage, and that no seeds germinated at a PEG-6000 concentration of 20%. In histomorphology, it was noted that the chloroplast of seedling leaf cells was deformed and vacuolized. The mitochondria structure was damaged in the leaf and root cells. By further analyzing part of the physiological and biochemical parameters of seedlings under drought stress, we showed that antioxidant enzymes such as catalase, peroxidase, and superoxide dismutase responded rapidly under drought stress. The seedlings accumulated a large amount of malondialdehyde under high drought stress. Additionally, drought stress affected the accumulation of proline and photosynthetic pigments. To summarize, drought stress affects seed germination and seedling growth in F. ferulaeoides; heavy drought should be avoided during the germination stage; and seedlings should not be exposed to long-term drought or severe drought. Our results provide information that may be useful for future artificial cultivation.
From Data to Insight: Predicting Interstitial Glucose in Healthy Cohort with Non-invasive Sensor Technology and Machine Learning
Authors: Huang Xinyu , Schmelter Franziska , Seitzer Christian , Martensen Lars , Otzen Hans , Piet Artur , Witt Oliver , Schröder Torsten , Günther Ulrich , Grzegorzek Marcin , Sina Christian 
Published: July 2023

Abstract
Continuous glucose monitoring (CGM) has transformed the care of diabetes mellitus patients. It is increasingly used to support nutritional management in various pathophysiologic conditions, including obesity and migraine, where avoiding postprandial hyperglycemia is critical to prevent hyperinsulinemia and low glucose levels after meal intake. However, the current CGM devices have significant limitations, such as invasiveness, availability, high cost, and limited shelf life, which must be overcome for broader use, specifically in disease prevention and obesity management. Therefore, we collected over 15,500 interstitial glucose measurements by CGM with a large amount of corresponding multimodal non-invasive wearable sensor data for healthy cohorts and used the machine learning (ML) approach to discover their correlations and accurately predict the postprandial glucose response (PPGR) in real-time over ten days, with an average Root Mean Squared Error (RMSE) of 18.49 ± 0.1 mg/dL and an average Mean Absolute Percentage Error (MAPE) of 15.58 ± 0.09%. It demonstrated that ML could facilitate non-invasive blood glucose measurements and opened new opportunities for efficient and objective nutritional-based disease prevention.
Is Telomeric Length in Cell Subtypes Related to Frailty Syndrome in Community-dwelling Older Adults?
Authors: Pereira Fabiana Souza Máximo , Thomasini Ronaldo Luis , Pereira Daniele Sirineu , Silva Thyago José , Leite Cleyde Amaral , Reis Luis Guilherme Oliveira , Camara Vitor Amorim Andrade , Costa Matheus Brum Rodrigues , Bakir João Víctor Santos , Xavier Laise Santos , Parentoni Adriana Netto , Pereira Leani Souza Maximo , Lacerda Ana Cristina 
Published: July 2023

Abstract
Leukocyte telomere length in the older adults has been associated with cell aging and the relationship with frailty syndrome is unclear. Factors that interfere with telomere shortening could be similar to those linked to frailty. The aims of this study were to compare the relative telomeric length (RTL) in DNA extracted from whole blood leukocytes, mononuclear cells and granulocytes of the community-dwelling older adults classified as frail, non-frail, and pre-frail, and to evaluate if there is a relationship between telomeric length in subpopulations of cells classified in frailty subgroups in community-dwelling older adults. This is an observational, cross-sectional, multicentric study conducted with older Brazilian adults. Sample characterization was performed using a sociodemographic clinical questionnaire. Telomere length was evaluated by quantitative polymerase chain reaction and frailty was classified by phenotypic criteria proposed by Fried et al. 2001. A total of 111 older adults (age 70.4 ± 5.4 years) were enrolled in this study. The mononuclear cell RTLs were shorter than granulocytes RTL and whole blood leukocyte RTL. No significant differences were found between whole blood leukocyte RTL and granulocyte RTL. Also, no significant association was found between frailty classification groups and any cell population. Although telomere shortening was not directly attributed to frailty syndrome, the shorter mononuclear cell RTL may be linked to the immunosenescent status which is one of the components of frailty syndrome. The lack of relationship between mononuclear cell RTL and frailty syndrome could be explained by the physical phenotypic feature of the classification in frailty subgroups. This study may contribute to clarifying the telomere length of cell subtypes and its association with immunosenescence and frailty syndrome, enabling the advancement of knowledge about aging process.
The outcome of buccal mucosal graft anterior urethroplasty techniques in men with urethral stricture
Authors: Gupta Radheshyam , Wang Honglei , An Wenxin , Xu Tao , Gupta Suman , Xu Wanhai , Lal Nand 
Published: July 2023

Abstract
Using Direct Visualisation Internal Urethrotomy (DVIU) and surgical evacuation of the stricture using a reconstructive buccal mucosal graft, urethral stricture is a condition that can be treated. This research aims to assess the success rate and risk factors for complications following buccal mucosal graft (BMG) urethroplasty for anterior urethral stricture in patients referred to a high-volume referral centre. Method: Between 2012 and 2019, 130 patients who underwent various types of BMG urethroplasty under a retrospective research by our team. Patient demographics, stricture aetiology, and anatomy, as well as adverse stricture outcomes like issues, erectile dysfunction (ED) lasting longer than 12 months, and post-micturition dribbling (PMD), were shown in order to identify success rate, risk factors for recurrent stricture, complications, and failure in terms of stricture recurrence. Results: There were 130 patients in all. The overall number of recurring strictures was 15.3% (20 males), whereas the success rate was reported to be 84.6% (n = 110). An ED occurred in 11% (n = 14) and PMD in 14% (n = 18). All of the Ed was not organic and was given a PDE5 inhibitor orally. Twenty patients (15.3%) experienced postoperative problems. Urinary fistula (n = 4, 3.0%), graft contracture (n = 3, 2.3%), graft failure (n = 5, 3.8%), UTI (n = 4, 3.0%), and wound infection (n = 3, 2.3%) were the most common complications following penile urethroplasty. Age at surgery, aetiology, stricture length, and location were all significant variables for stricture recurrence in the univariate analysis. In the multivariate analysis, the penile location was the only significant independent variable for restricture. Conclusion: The remarkable results of BMG urethroplasty as a therapy for anterior urethral stricture with a success rate of 84.6% represent improvements in the quality of care in resource-constrained nations like Nepal.
Early HIV-1 Gag Assembly on Lipid Membrane with vRNA
Authors: Williamson James , Zhou Anne , Hammond John , Sheng Kai , Millar David 
Published: July 2023

Abstract
HIV-1 capsid assembly is an essential process in the virus infection cycle. Initiation of capsid assembly involves viral proteins, genomic RNA, and the inner leaflet of the plasma membrane, facilitated by a number of cellular factors1. The viral structural protein Gag plays a 10 number of central roles in this process, including association with the membrane, selective binding of genomic RNA, and oligomerization and packaging to ultimately produce an immature budded pro-viral particle2. While there have been intensive studies regarding the early stages of Gag assembly, there is a lack of consensus on the mechanism for nucleation and growth of Gag complexes3-7. Here we show that myristoylated Gag forms a trimer nucleus in a model 15 membrane that can selectively bind a dimeric RNA containing the packaging signal. Subsequent growth of myristoyl-Gag oligomers requires vRNA, and occurs by addition of 1 or 2 Gag monomers at a time from solution. These data support a model where the immature capsid lattice formation occurs by a gradual lattice edge expansion, following a trimeric nucleation event. The dynamic single molecule data that support this model were recorded using mass photometry, 20 involving full length myristoylated protein, RNA, and lipid together. These data are the first to support a lattice edge expansion model of Gag during early stages of assembly in a biological-relevant setting, providing insights to the fundamental models of virus structural protein assembly process.
Stemness Landscape and Its Clinical Implications in Hepatocellular Carcinoma
Authors: Gong Xuankun , Bao Ling , Chen Yuanrong , Qu Kanglin , Zhou Shuai , Chen Xiao , Pang Qing 
Published: July 2023

Abstract
Background: It is generally accepted that hepatocarcinoma(HCC) originates from cancer stem cells (CSCs), which are responsible for HCC progression, metastasis and therapy resistance. The high heterogeneity of CSCs has precluded clinical application of CSC-targeting therapy. Here, we aimed to characterize the stemness landscapes and screen for certain patients more responsive to immunotherapy.
Methods: Our study characterized two stemness-related subtypes with different prognosis and TME patterns in HCC patients, and constructed a 4-gene stemness-risk model through extensive bioinformatics analysis. We believe that our stem cell model has prospective clinical implications for prognostic assessment and may help physicians select prospective responders to prioritize the use of current immune checkpoint inhibitors.
Results: Based on single-sample gene set enrichment analysis (ssGSEA) enrichments scores, HCC patients were classified into two subtypes (C1 and C2). The KM survival curve showed that C2 cluster had longer survival and better prognosis than C1 cluster. C2 had more significant Mast cell infiltration than C1. However, the infiltration of T cells CD4 memory resting\Dendritic cells\T cell regulatory (Tregs) was more pronounced in C1 than in C2. Patients in C2 had higher response rates to immunotherapy and were more likely to benefit from immunotherapy. C1 has a higher probability of immune escape than C2.
Conclusion: Our study highlights the importance of precise molecular subtyping of stemness in HCC. The identification of two distinct stem cell subtypes, C1 and C2, provides valuable insights into the clinical heterogeneity of HCC and its correlation with prognosis, TME characteristics, and immunotherapy response rates.