bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histological markers, sickle-shaped blood vessels, myxoid area, and infiltrating growth pattern help stratify the prognosis of patients with myxofibrosarcoma/undifferentiated sarcoma
Authors: Washimi Kota , Kasajima Rika , Shimizu Eigo , Sato Shinya , Okubo Yoichiro , Yoshioka Emi , Narimatsu Hiroto , Hiruma Toru , Katayama Kotoe , Yamaguchi Rui , Yamaguchi Kiyoshi , Furukawa Yoichi , Miyano Satoru , Imoto Seiya , Yokose Tomoyuki , Miyagi Yohei 
Published: April 2023

AbstractMyxofibrosarcoma (MFS) and undifferentiated sarcoma (US) have been considered as tumors of the same lineage based on genetic/epigenetic profiling. Although MFS shows a notably better prognosis than US, there are no clear criteria for distinguishing between them. Here, we examined 85 patients with MFS/US and found that tumors with infiltrative growth patterns tended to have more myxoid areas and higher local recurrence rates but fewer distant metastases and better overall survival. Morphologically characteristic sickle-shaped blood vessels, which tended to have fewer αSMA-positive cells, were also observed in these tumors, compared with normal vessels. Based on the incidence of these sickle-shaped blood vessels, we subdivided conventionally diagnosed US into two groups. This stratification was significantly correlated with metastasis and prognosis. RNA sequencing of 24 tumors (9 MFS and 15 US tumors) demonstrated that the proteasome, NF-kB, and VEGF pathways were differentially regulated among these tumors. Expression levels of KDR and NFATC4, which encode a transcription factor responsible for the neuritin-insulin receptor angiogenic signaling, were elevated in the sickle-shaped blood vessel-rich US tumors. These findings indicate that further analyses may help elucidate the malignant potential of MFS/US tumors as well as the development of therapeutic strategies for such tumors.
Multifunctional Zn and Ag co-doped bioactive glass nanoparticles for bone therapeutic and regeneration
Authors: Naruphontjirakul Parichart , Kanchanadumkerng Pimpikar , Ruenraroengsak Pakatip 
Published: April 2023

AbstractBone cancer has traditionally been treated using surgery, radiotherapy, and/or chemotherapy. The nonspecific distribution of chemotherapy and implantable infections are significant risk factors for the failure of the bone to heal. Multifunctional zinc and silver co-doped bioactive glass nanoparticles (yAg–xZn-BGNPs) with a diameter of 150 ± 30 nm were successfully synthesized using modified sol–gel and two-step post-functionalization processes, tailored to provide antibacterial and anticancer activity whilst maintaining osteogenesis ability. Co-doped BGNPs with Zn and Ag did not significantly alter physicochemical properties, including size, morphology, glass network, and amorphous nature. Apatite-like layer was observed on the surface of yAg–xZn-BGNPs and resorbed in the simulated body fluid solution, which could increase their bioactivity. Human fetal osteoblast cell line (hFOB 1.19) treated with particles showed calcified tissue formation and alkaline phosphatase activity in the absence of osteogenic supplements in vitro, especially with 0.5Ag–1Zn-BGNPs. Moreover, these particles preferentially disrupted the metabolic activity of bone cancer cells (MG-63) and had an antibacterial effect against B. subtilis, E. coli, and S. aureus via the disc diffusion method. This novel 0.5Ag–1Zn-BGNP and 1Ag–1Zn-BGNPs, with wide-ranging ability to stimulate bone regeneration, to inhibit bone cancer cell proliferation, and to prevent bacterial growth properties, may provide a feasible strategy for bone cancer treatment. The 0.5Ag–1Zn-BGNPs and 1Ag–1Zn-BGNPs can be applied for the preparation of scaffolds or filler composites using in bone tissue engineering.
Dietary protocatechuic acid redistributes tight junction proteins by targeting Rho-associated protein kinase to improve intestinal barrier function
Authors: So Bo Ram , Kim San , Jang Se Hyeon , Kim Min Jeong , Lee Jeong Jae , Kim Soo Rin , Jung Sung Keun 
Published: April 2023

Proposed molecular mechanism of PCA on redistribution of tight junction proteins, intestinal permeability, and subsequent IBD, both in vitro and in vivo.
Primary Open-Angle Glaucoma Progression in Glaucoma Patients with Unchanged Topical Treatment over 3 Years – Retrospective Observational Cohort Analysis
Authors: Saruhan Yasemin , Hasler Pascal W. , Gugleta Konstantin 
Published: April 2023

Abstract
Background Lowering intraocular pressure (IOP) is a mainstay of glaucoma therapy. It is, however, still an open question whether a comparable level of long-term IOP lowering achieved
by different medications results in comparable protection for the retinal ganglion cells. The purpose of this study was to retrospectively analyze glaucoma damage progression in two cohorts
of primary open-angle glaucoma patients with different and unchanged therapy over a period of 3 years, and the main objective of this study was to determine possible differences in terms of
structural [retinal nerve fiber layer thickness (RNFL)] and functional [visual field (VF)] outcome.
Patients and Methods The retrospective observational cohort analysis compared two differently treated groups of glaucoma patients with their original, at study entry, topical therapy
unchanged over 3 years. The main endpoint was the time course of RNFL thickness and VF mean defect (MD).
Results Twenty-one eyes were included in each group. The first group (21 eyes) was on a fixed combination of timolol and dorzolamide twice a day and the second group on one drop of
prostaglandin analog, either latanoprost alone (15 eyes) or travoprost alone (6 eyes), in an unchanged regimen over a period of 3 years. IOP in mmHg at baseline and at 36 months was
11.9 ± 2.4 and 13.0 ± 2.1 in the first, and 12.9 ± 3.0 and 14.1 ± 3.2 in the second group, respectively. RNFL thickness values in micrometers were at baseline and at 36 months 77.8 ± 12.3
and 76.6 ± 15.2 in the first, and 77.5 ± 15.2 and 72.8 ± 14.5 in the second group, respectively. VF MD in dB were 1.7 ± 2.5 and 1.2 ± 2.9 in the first, and 0.9 ± 2.3 and 0.7 ± 2.6 in the
second group, respectively.
Conclusion Both groups had comparable baseline, as well as mean overall IOP. However, the course of IOP levels over time was different in the two groups, showing earlier and more
pronounced long-term drift in the prostaglandin analog-treated group. RNFL thickness was comparable at baseline, however, RNFL thinning over time was more pronounced in the prostaglandin
analog-treated group. There were no statistical differences between the groups in terms of VF MD at baseline and over time.
Refraktive Ergebnisse nach der Implantation torischer Intraokularlinsen mithilfe des Zeiss Callisto-Systems
Authors: Raemy Kenji , Scherrer Mark , Stürmer Jörg Peter Egon 
Published: April 2023

Zusammenfassung
Hintergrund Für Kataraktpatienten mit Astigmatismus ist das Einsetzen von torischen Intraokularlinsen eine sichere und effektive Methode, um eine Emmetropie zu erzielen. Dabei ist
die exakte Ausrichtung der Linse entlang der berechneten Achse essenziell für eine effektive Astigmatismuskorrektur. Das Ziel dieser Studie ist die Auswertung der Daten mittels deskriptiver
Statistik. Der primäre Fokus liegt dabei auf den refraktiven Ergebnissen und somit der Überprüfung der Ausrichtungsgenauigkeit von torischen IOL mit dem Zeiss Callisto-System.
Patienten und Methoden Für die Studie wurden insgesamt 106 Augen von 72 Patienten ausgewertet, die zwischen Januar 2019 und Dezember 2020 eine Kataraktoperation mit Implantation
einer torischen Intraokularlinse im Kantonsspital Winterthur erhalten haben. Die präoperative Biometrie und intraoperative Markierung der Implantationsachse wurde mithilfe des Zeiss
Callisto-Systems durchgeführt. Die postoperativen Kontrollen erfolgten nach 1 Tag, nach 1 Woche und nach 4 Wochen im Kantonsspital Winterthur oder beim zuweisenden Augenarzt. Für die
Auswertung wurden nur die Daten der 4-wöchigen Kontrolle verwendet.
Ergebnisse In 64 Augen (60%) wurde eine Zeiss AT Torbi 709 M oder MP sowie in 42 Augen (40%) eine PhysIOL Ankoris toric yellow IOL implantiert. Bei 46 Augen wurde der postoperative
unkorrigierte Visus nicht erfasst. Von den übrigen 60 Augen betrug der durchschnittliche postoperative unkorrigierte Visus 0,07 ± 0,12 logMAR. Dabei konnte bei 48% der Augen ein
postoperativer unkorrigierter Visus ≥ 1,0 (dezimal) und bei 92% ein Visus ≥ 0,6 (dezimal) erzielt werden. Der postoperative Zylinder betrug im Durchschnitt − 0,65 ± 0,53 dpt. Der Zylinder
der Zielrefraktion war durchschnittlich − 0,45 ± 0,39 dpt. Der Mittelwert des Betrags des postoperativen Zylinders abzüglich des Zylinders der Zielrefraktion war 0,42 ± 0,32 dpt.
Schlussfolgerungen Das Zeiss Callisto-System ist eine effektive Methode mit sehr guten klinischen Ergebnissen, um torische Intraokularlinsen entlang der Implantationsachse
auszurichten.
Clinical Heterogeneity in Two Siblings Harbouring a Heterozygous PRPH2 Pathogenic Variant
Authors: Sanlialp Ayse , Escher Pascal , Schaller André , Todorova Margarita 
Published: April 2023

Abstract
Purpose The aim of the study was to describe the clinical and genetic correlation of a c.469 G>A p.(Asp157Asn) heterozygous pathogenic variant in PRPH2 in two siblings of Italian
origin.
Patients and Methods Both patients underwent ophthalmic examination, electrophysiological testing, autofluorescence imaging, and optical coherence tomography (OCT). Screening for
pathogenic variants of the obtained DNA from the family members was carried out.
Results The 52-year-old (♀, index patient) and 50-year-old (♂) siblings had BCVA (OD and OS) of 20/20 and 20/16 (♀) and 20/25 and 20/40 (♂), respectively, and suffered increased
sensitivity to glare. Yellow irregular macular deposits, numerous small irregular hypo- and hyperreflective spots at the posterior pole, a patchy loss of photoreceptors, and retinal pigment
epithelium (RPE) in the perifoveal region were seen. Electrophysiology showed dysfunction of rods and cones, with more affected cone dysfunction in the index patient, contrary to the
generalised rod dysfunction in the brother of the index patient. The clinical, electrophysiological, and multimodal imaging findings of both siblings pointed towards Stargardt retinopathy
with heterogenic presentation. The DNA analysis identified an autosomal dominant c.469 G>A p.(Asp157Asn) heterozygous pathogenic variant in PRPH2 associated with autosomal dominant
cone-rod dystrophy and rod-cone dystrophy. PRPH2 codes for peripherin-2, a membrane protein that consists of 346 amino acids.
Conclusions Our findings confirm a heterogeneity in clinical presentation associated with pathogenic variants in PRPH2. It may follow either an autosomal dominant or an autosomal
recessive mode of inheritance and show a very heterogeneous clinical manifestation of retinal degeneration, e.g., autosomal dominant retinitis pigmentosa (♂ sibling; II-3) and autosomal
dominant cone-rod dystrophy (index ♀ sibling; II-2), autosomal dominant macular dystrophy, and also autosomal recessive retinitis pigmentosa.
Revisiting the Classification of Moderate and Mild Traumatic Brain Injury Based on the Admission Glasgow Coma Scale Score
Authors: Swaminathan Ganesh , Abraham Ananth P. , Mani Thenmozhi , Joseph Mathew 
Published: April 2023

Abstract
Objective We study the clinical relevance of classifying traumatic brain injury (TBI) into moderate and mild categories based on the Glasgow Coma Scale (GCS) score at admission with respect to the treatment intensity and 6-month mortality and morbidity rates.
Methods Analysis of patients from a prospectively maintained database admitted at a level I trauma center from 2013 to 2019 with an admission GCS score between 9 and 15 and a minimum follow-up of 6 months post-TBI was done to study the treatment intensity and 6-month morbidity and mortality rates for each GCS score from 9 to 15.
Results In all, 2,060 patients met the study criteria, of which 1,684 were males (81.7%). Road traffic accident was the most common cause of TBI (83.7%). There was a significant linear increase in the proportion of patients who had good outcomes with increasing GCS scores from 9 to 15 (p ≤ 0.001). When the variables in each GCS score were compared with a GCS score of 15, there was an increase in the odds ratio of mortality and poor outcome with decreasing GCS scores (p ≤ 0.001). Patients with a lower admission GCS score required more intense treatment in the form of surgery and ventilation (p ≤ 0.00001). There was a higher incidence of pupillary asymmetry in patients with lower GCS scores (p ≤ 0.00001).
Conclusions The classification of TBI patients into moderate and mild based on the GCS score at admission is not of any practical value, and TBI patients may be more usefully classified based on the admission GCS score into severe and not severe groups.
Enhanced extreme ultraviolet free induction decay emission assisted by attosecond pulses
Authors: Tao Wenkai , Wang Li , Song Pan , Xiao Fan , Wang Jiacan , Zheng Zhigang , Zhao Jing , Wang Xiaowei , Zhao Zengxiu 
Published: April 2023

Abstract
We demonstrate that the extreme ultraviolet free induction decay emission can be significantly enhanced by employing isolated attosecond pulses. In this work, the near infrared pulses are applied to excite the neon atoms into Rydberg states coherently, and isolated attosecond pulses are used to manipulate the populations of the Rydberg states and the subsequent free induction decay process. The time resolved experimental measurement of the dependence of the resonance emission yield would help to understand the buildup dynamics of population of excited states. The enhancement assisted by attosecod pulses can serve as a mechanism to develop high-flux extreme ultraviolet light sources.
Representation Theory of Geigle-Lenzing Complete Intersections
Authors: Herschend Martin , Iyama Osamu , Minamoto Hiroyuki , Oppermann Steffen 
Published: April 2023

Weighted projective lines, introduced by Geigle and Lenzing in 1987, are important objects in representation theory. They have tilting bundles, whose endomorphism algebras are the canonical algebras introduced by Ringel. The aim of this paper is to study their higher dimensional analogs. First, we introduce a certain class of commutative Gorenstein rings

R
R

graded by abelian groups

L

\mathbb {L}

of rank

1
1

, which we call Geigle-Lenzing complete intersections. We study the stable category

C
M

_

L

R

\underline {\mathsf {CM}}^{\mathbb {L}}R

of Cohen-Macaulay representations, which coincides with the singularity category

D

s
g

L

(
R
)

\mathsf {D}^{\mathbb {L}}_{\mathrm {sg}}(R)

. We show that

C
M

_

L

R

\underline {\mathsf {CM}}^{\mathbb {L}}R

is triangle equivalent to

D

b

(

m
o
d

A

C
M

)

\mathsf {D}^{\mathrm {b}}(\mathsf {mod} A^{\mathrm {CM}})

for a finite dimensional algebra

A

C
M

A^{\mathrm {CM}}

, which we call the CM-canonical algebra. As an application, we classify the

(
R
,

L

)

(R,\mathbb {L})

that are Cohen-Macaulay finite. We also give sufficient conditions for

(
R
,

L

)

(R,\mathbb {L})

to be

d
d

-Cohen-Macaulay finite in the sense of higher Auslander-Reiten theory. Secondly, we study a new class of non-commutative projective schemes in the sense of Artin-Zhang, i.e. the category

c
o
h

X

=

m
o
d

L

R

/

m
o
d

0

L

R

\mathsf {coh}\mathbb {X}=\mathsf {mod}^{\mathbb {L}}R/\mathsf {mod}^{\mathbb {L}}_0R

of coherent sheaves on the Geigle-Lenzing projective space

X

\mathbb {X}

. Geometrically this is the quotient stack

X

=
[
X

/

G
]

\mathbb {X}=[X/G]

for

X
=

S
p
e
c

R
∖
{

R
+

}

X={\mathrm {Spec}}\,R\setminus \{R_+\}

and

G
=

S
p
e
c

k
[

L

]

G={\mathrm {Spec}}\,k[\mathbb {L}]

. We show that

D

b

(

c
o
h

X

)

\mathsf {D}^{\mathrm {b}}(\mathsf {coh}\mathbb {X})

is triangle equivalent to

D

b

(

m
o
d

A

c
a

)

\mathsf {D}^{\mathrm {b}}(\mathsf {mod} A^{ca})

for a finite dimensional algebra

A

c
a

A^{\mathrm {ca}}

, which we call a

d
d

-canonical algebra. We study when

X

\mathbb {X}

is

d
d

-vector bundle finite, and when

X

\mathbb {X}

is derived equivale’nt to a

d
d

-representation infinite algebra in the sense of higher Auslander-Reiten theory. Our

d
d

-canonical algebras provide a rich source of

d
d

-Fano and

d
d

-anti-Fano algebras in non-commutative algebraic geometry. We also observe Orlov-type semiorthogonal decompositions of

D

s
g

L

(
R
)

\mathsf {D}_{\mathrm {sg}}^{\mathbb {L}}(R)

and

D

b

(

c
o
h

X

)

\mathsf {D}^{b}(\mathsf {coh}\mathbb {X})

.
Chronic kidney disease in children: an update
Authors: Cirillo Luigi , De Chiara Letizia , Innocenti Samantha , Errichiello Carmela , Romagnani Paola , Becherucci Francesca 
Published: April 2023

ABSTRACT
Chronic kidney disease (CKD) is a major healthcare issue worldwide. However, the prevalence of pediatric CKD has never been systematically assessed and consistent information is lacking in this population. The current definition of CKD is based on glomerular filtration rate (GFR) and the extent of albuminuria. Given the physiological age-related modification of GFR in the first years of life, the definition of CKD is challenging per se in the pediatric population, resulting in high risk of underdiagnosis in this population, treatment delays and untailored clinical management. The advent and spreading of massive-parallel sequencing technology has prompted a profound revision of the epidemiology and the causes of CKD in children, supporting the hypothesis that CKD is much more frequent than currently reported in children and adolescents. This acquired knowledge will eventually converge in the identification of the molecular pathways and cellular response to damage, with new specific therapeutic targets to control disease progression and clinical features of children with CKD. In this review, we will focus on recent innovations in the field of pediatric CKD and in particular those where advances in knowledge have become available in the last years, with the aim of providing a new perspective on CKD in children and adolescents.
Ride-Sharing and the Geography of Consumption Industries
Authors: Norris Jordan J , Xiong Heyu 
Published: April 2023

Abstract
Cities are centres of the consumption industries—establishments offering nightlife, food, recreation and retail. However, the city’s associated consumer value is inseparable from its geography because residents must travel to consume. By exploiting both the staggered entry across cities and the precise geographic boundary of Uber services for credible identification, we show that the introduction of ride-share technology into a city caused large and significant growth in the consumption industries. We provide evidence that the results are driven by an increase in consumer mobility, due to Uber causing a reduction in the economic cost of travel.
Invoking the Paris Agreement in Investor-State Arbitration
Authors: Sarvarian Arman 
Published: April 2023

Abstract
In recent years, there has been mounting interest in the possibility of the Paris Agreement 2015 featuring in investor-State arbitration.2 This applies particularly to investments connected to greenhouse gas emissions mitigation, insured emissions and other financial investments to be made under the internationally supervised emission-offsetting mechanism to be activated in accordance with the Glasgow Climate Pact 2021.3 While modernisation reforms to the Energy Charter Treaty (ECT) are anticipated to include direct reference to the Paris Agreement, their effect has been thrown into doubt by recent withdrawals of EU Member States. Although the past two years have seen increasingly successful efforts to enforce the Paris Agreement before national courts, a disputing party has yet to invoke it in an investor-State arbitration. Whereas environmental exception clauses, direct references to the Paris Agreement and substantive obligations on environmental protection remain rare in international investment agreements, this situation is likely to change as ‘green investment’ expands and high-emission investors react to intensification of host State efforts to mitigate emissions. In analysing recent arbitral jurisprudence on the right of regulation, it is suggested that the most significant effect of the Paris Agreement on international investment law may be in defining the investment relationship of the disputing parties with respect to the liability of the host State for alleged breaches of the substantive protections for the investment under investment treaties, contracts and laws.
February 2023 Updates of the Advisory Committee on Immunization Practices
Authors: Gaviria-Agudelo Claudia , Yonts Alexandra B , Kimberlin David W , O’Leary Sean T , Paulsen Grant C 
Published: April 2023

Abstract
The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts who provides expert advice to the Centers for Disease Control and Prevention, normally meets three times per year to develop U.S. vaccine recommendations. The ACIP met on February 22–24, 2023, to discuss mpox vaccine, influenza vaccines, pneumococcus vaccines, meningococci vaccines, polio vaccines, respiratory syncytial virus (RSV) vaccine, chikungunya vaccines, dengue vaccines, and COVID-19 vaccines.
Novel Approach for Umbilical Hernia Repair Using Mesh Strips
Authors: Moradian Simon , Klosowiak Julian L. , Boctor Michael J. , Issa Tariq , Park Seong , Dumanian Gregory A. 
Published: April 2023

Background:
Umbilical hernia repair is a common surgical procedure without a universally accepted means of repair. We introduce a novel surgical technique for open primary umbilical hernia repair, using strips of polypropylene mesh as sutures to achieve a repair.

Methods:
Two-centimeter-wide strips of macroporous polypropylene mesh were passed through the abdominal wall and tied as simple interrupted sutures to achieve umbilical hernia repair. A retrospective review of all elective umbilical hernia repairs performed by a single surgeon using the mesh strip technique between 2016 and 2021 was conducted, and patient-reported outcomes were assessed via a telephonic survey.

Results:
Thirty-three patients underwent an elective, open mesh strip repair of a primary umbilical hernia and met criteria for inclusion in the study. Of these patients, 60% responded to a patient-reported outcomes telephone survey. Ninety percent of survey responders reported a pain score of 0 of 10. Additionally, 90% reported being unable to feel or palpate the knot, and 80% reported an improvement in quality of life. Mean follow-up at 3 years revealed one recurrence in the setting of ascites, yielding a recurrence rate of 3%.

Conclusion:
Primary mesh strip repair of umbilical hernias combines the simplicity of suture repair with the advantageous force distribution properties of mesh, and constitutes a safe, efficient, and effective method of repair with a low recurrence rate at long-term follow-up that is comparable to planar mesh repair.