bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trip purpose inference and spatio-temporal characterization based on anonymized trip data - an empirical study from dockless shared bicycle dataset in Xi'an, China
Authors: Wang Jianwei , Cui Mengyan , Yang Hao , Fu Sen , Liu Xuxu , Fu Xin 
Published: May 2023

Abstract
The development of IoT and big data technology has generated massive personal travel data. While most of the data is anonymized, it still provides more possibilities for analyzing individual travel behavior. It is worthwhile to keep exploring how to more accurately infer travel purposes based on trajectory data, smart card fare data, or shared bicycle data. In this paper, an improved research framework is proposed for travel purpose inference by applying the gravity model, Bayesian criterion and spatial clustering method. The gravity model and Bayesian rule are used to calculate the probability of users traveling to nearby POIs, and the clustering algorithm is used to identify the locations regularly visited by users. Through the identification of maximum probability POI and regular trips, different travel purposes represented by POI can be distinguished. The results showed that the identification of regular trips could verify and complement the recognition of trip purposes by POIs. Using Xi'an city of China as an example for the study, the results show that regular trips accounted for 32% of the week's trips. Of these regular trips, 30% of the trips are most likely togo to malls, restaurants, hospitals, or recreational areas. While these POIs often represent trip purposes such as shopping, eating, medical care, and entertainment, the purpose of these trips is more likely to be commuting due to the regularity of the trip. Ultimately, there are 10% of the trips reflect different trip purposes for the same POI. And there is a distance worth noting. 70% of the users have a parking error of fewer than 100 meters when going to the exact location. This distance can provide a reference for the study of bicycle commuting. Finally, we analyzed the different trip purposes' spatial and temporal distribution characteristics. The analysis of the spatial and temporal distribution can provide suggestions for the operation of bike-sharing enterprises and the management of regulators.
Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 in regulating placentation and pregnant maintenance
Authors: Ruan Hongfeng , Zhu Haibin , Luo Huan , Wu Xiaowei , Bao Hangyang , Ji Xing , Fan Xueying , Pan Yibin , Tang Chao , Wu Ximei 
Published: May 2023

Abstract
Vitamin C (VC) is an essential nutrient for anti-oxidation, metabolic reaction, and stem cell differentiation. However, the precise role of VC in placentation and pregnant maintenance remains unknown. Here, we demonstrate that physiological concentration of VC stabilizes the Hand1, a bHLH transcription factor crucial for the development of trophoblast giant cell (TGC) lineage, to promote the differentiation of trophoblast stem cells into TGCs. The role of VC depends on the inactivation of JNK kinase, which directly phosphorylates Hand1 at Ser48 and thereby induces Hand1 proteasomal degradation, whereas loss-of-function mutation of Ser48 on Hand1 robustly decreases not only the basal but also VC-induced Hand1 stabilization. As a result, VC deficiency, lentiviral knockdown of JNK or overexpression of Hand1 mutants in trophectoderm significantly affects the differentiation of primary and secondary TGCs in E8.5 mouse placentas. VC deficiency causes a severe defect in the differentiation of diverse TGCs and the formation of vascular network of labyrinth in mature mouse placentas and thereby fails to maintain the pregnancy. Thus, these results uncover JNK inactivation and subsequent Hand1 stabilization as a hitherto uncharacterized mechanism controlling VC-mediated placentation and perhaps pregnant maintenance.
Adjuvant Lenvatinib in Combination with Transarterial Chemoembolization for Hepatocellular Carcinoma Patients with High-Risk of Postoperative Recurrence (LANCE): A Multicenter Prospective Cohort Study
Authors: Chen Jinhong , Lu Lu , Zhang Xiaoyun , Xiang Bangde , Xu Xiao , Li Xiangcheng , Huang Zhiyong , Wen Tianfu , Luo Liuping , Huang Jing , Zhong Jian-Hong , Liu Zhikun , Li Changxian , Long Xin , Zhu Wenwei , Yang Xing , Wang Chaoqun , Jia Huliang , Zhang Jubo , Zeng Yongyi , Lu Caide , Qin Lun-Xiu 
Published: May 2023

Abstract
Purpose: To evaluate the efficacy and safety of lenvatinib in combination with transarterial chemoembolization (TACE) as an adjuvant therapy in HCC patients with high-risk of postoperative recurrence.
Methods: This study was a prospective cohort study. Patients who met the eligible criteria were recruited between November 2018 to May 2021 from 8 hepatobiliary centers in China. The primary endpoint was disease-free survival (DFS). The secondary endpoints were overall survival (OS) and safety. The treatment-related adverse events (AEs) were recorded throughout the entire study period.
Results: A total of 297 patients were enrolled, with 147 patients in the TACE + Lenvatinib (Len) group and 150 patients in the TACE group. The baseline characteristics were well balanced between the two groups. Patients in the TACE + Len group achieved significantly better DFS. The median DFS was 19.0 months [95% confidence interval (CI), 14.0-25.0] and 10.0 months [95% CI, 8.0-13.0] in the TACE + Len and TACE group, respectively (log-rank test p= 0.011). The adjusted hazard ratio (HR) of disease recurrence for baseline prognostic variables between the two groups was 0.68 (95% CI, 0.50–0.91, p = 0.009). Lenvatinib treatment-related AEs of grade 3 or 4 occurred in 28.6% of the patients in TACE + Len group.
Conclusions: This study suggested that adjuvantTACE plus lenvatinib a promising approach for HCC patients with high-risk of postoperative recurrence, which could significantly reduce postoperative recurrence and prolong survival with a manageable safety profile.
Micro-manufacturing of Powder Bed Fused stainless steel: Micro-machining and Micro-electrical discharge machining
Authors: Abeni Andrea , Quarto Mariangela , Ginestra Paola Serena 
Published: May 2023

Abstract
Nowadays, additive manufacturing technologies are widely studied for tailoring the final characteristics of the produced parts. In particular, Powder Bed Fusion technologies are widely applied for manufacturing metal components, and they allow the production of near-net shape parts. However, due to the poor surface quality of as-built samples, the application of the micro-machining, in several cases is essential for obtaining the final requirements, both in terms of dimensional accuracy and surface finishing. Therefore, during Micro-Mechanical Machining and Micro-Electrical Discharge Machining operations, it is important to analyse the material removal behaviour of Powder Bed Fusion specimens in order to identify their machinability responses., In this paper, we present comparative research on micro-machining of 17-4 PH stainless steel samples produced by Laser Powder Bed Fusion. Specifically, we performed Micro-Mechanical Machining and Micro-Electrical Discharge Machining operations, analysed the process performances, and compared the machining conditions. Additionally, we investigated the surface roughness and burrs extension as a function of geometry configuration and process parameters.
Effects of General Anesthesia Combined with Epidural Anesthesia and Analgesia on Postoperative Short-term Outcomes after Laparoscopic Gastrectomy in Elderly Patients with Gastric Cancer
Authors: Yu Junjian , Zheng Taohua , Dong Zhensheng , Yuan Antai , Liu Qi , Jia Zhuoyu , Cao Shougen 
Published: May 2023

Abstract
BACKGROUND
Patient-controlled intravenous analgesia (PCIA) and patient-controlled epidural analgesia (PCEA) constitute two major advances in pain management after major abdominal surgery. However, the effect of PCIA or PCEA has not been particularly studied in elderly patients with gastric cancer.
AIM
To compare the effect of PCIA to that of PCEA on short-term outcomes in elderly patients undergoing laparoscopic gastrectomy.
METHODS
This single-center, retrospective study included 254 elderly patients (≥ 70 years) who underwent laparoscopic radical gastrectomy for gastric cancer. Patients received either general anesthesia combined with epidural anesthesia followed by PCEA (PCEA group, n = 123) or general anesthesia alone followed by PCIA (PCIA group, n = 131). The primary endpoint was pain intensity tested using a 100-mm visual analog scale (VAS) on postoperative days 1, 2, and 3. Demographics, comorbidities, perioperative data, postoperative short-term outcomes, and analgesia-related side effects were also assessed.
RESULTS
The VAS scores at rest were lower in the PCEA group compared to the PCIA group on postoperative day 1, 2, and 3 (27.8 ± 13.9 vs 33.1 ± 15.0, P = 0.004; 25.2 ± 11.3 vs 30.1 ± 14.3, P = 0.002; 16.9 ± 7.1 vs 20.9 ± 9.5, P < 0.001; respectively). The postoperative hospital stay was shorter in the PCEA group than in the PCIV group (11 vs 12 days, P = 0.018). The times to postoperative first flatus, semifluid diet, full ambulation, and tracheal extubation after surgery in the PCEA group were significantly shorter than in the PCIA group. Overall morbidity, mortality, hospital readmission rate, and reoperation rate were not significantly different between the two groups. Regarding side-effects related to analgesia, there were no significant differences in terms of the rates of postoperative nausea and vomiting, urinary retention, or oxygen saturation < 90% between the two groups. However, PCEA was associated with a higher incidence of postoperative hypotension compared to PCIA (10.6% vs 3.8%, P = 0.036).
CONCLUSIONS
In elderly patients undergoing laparoscopic radical gastrectomy, epidural anesthesia and analgesia may convey superior pain relief, faster restoration of gastrointestinal motility, and shorter hospitalization.
Critical Analysis of Macular Hole Repair Techniques: A Comprehensive Systematic Review and Meta-analysis Comparing Internal Limiting Membrane Flap and Internal Limiting Membrane Peeling For Any Size of Macular Hole
Authors: Akhtar Syed Muhammad Muneeb , Saleem Syed Zia , Rizvi Syed Ali Asad 
Published: May 2023

Abstract
Background:
Macular holes are a leading cause of visual impairment and blindness worldwide defined as a partial or full thickness anatomical defect in the fovea of the retina. Internal limiting membrane (ILM) peeling is a successful surgical procedure to repair the defect. However, it doesn’t have good efficacy with larger macular holes. Internal limiting membrane (ILM) flap is a novel technique and shows promising results.
Objective
This systematic review and meta-analysis aims to compare the effectiveness of these two techniques in treating any size and type of macular hole.
Methods
A comprehensive literature search was conducted in the PubMed, Medline, Cochrane Library and Web of Science databases to identify the relevant articles. The primary outcome measures were MH closure rate and postoperative visual acuity (VA).
The statistical power was ensured by performing heterogeneity, publication bias, sensitivity analysis, and subgroup analysis. Pooled odds ratios (ORs), weighted mean difference (WMD), and 95% confidence intervals (CIs) were calculated.
Results
A total of 8 RCTs and 18 Retrospective studies were included in this meta-analysis, which involved 1052 eyes in the ILM flap group and 1050 eyes in the ILM peeling group.
The overall MH closure rate came out to be in favor of ILM flap technique (OR=2.74, CI=1.62 TO 4.66; P = 0.0002). In overall analysis of postoperative VA, no significant difference was observed between the two surgical methods. However, it favored ILM flap technique on subgroup analysis based on study type and MH size specifically in the RCTS with macular hole size > 400μm (MD = -0.13, 95% CI = -0.16 to -0.09; P < 0.00001) as well as on subgrouping based on follow-up months duration I.e. on all the 3, 6 and 12 months (MD=-0.11, 95% CI = -0.19 to -0.04; P = 0.003), (MD=-0.11, 95% CI = -0.18 to -0.04; P = 0.002) and (MD=-0.12, 95% CI = -0.16 to -0.08; P <0.00001) respectively.
Conclusion
ILM flap technique resulted in better anatomical outcomes as well as better visual outcomes specifically in larger macular holes and at all the follow-up months. Hence, it is recommended that the inverted internal limiting membrane (ILM) flap method should routinely be chosen as the preferred treatment for patients who have macular holes larger than 400 micrometers.
A probiotic formulation protects the dopaminergic neurons via attenuating the intestinal inflammation in mice of Parkinson’s disease
Authors: Zhou Liping , Han Deqiang , Zheng Tianqi , Wang Xingzhe , Xie Hongxiang 
Published: May 2023

Abstract
Objective Targeting the intestinal inflammation becomes a strategy for Parkinson’s disease (PD) treatment. This study investigated the neuroprotective effects of a probiotic formulation, VSL#3® formulation, and the involvement of the anti-inflammation, in particular the intestinal inflammation.Materials and Methods The probiotics was orally administrated to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD for six weeks.Results The striatal content of dopamine and its metabolites, the survival of dopaminergic neurons in the substantia nigra were substantially increased in probiotics treatment mice compared to PD mice. The pro-inflammatory cytokines in the striatum were significantly suppressed while the anti-inflammation mediators were dramatically up-regulated by probiotics. The probiotics attenuated the intestinal inflammation via regulating the gut microbial composition. The mRNA expression of Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β) mRNA significantly decreased in probiotic treatment mice compared to PD mice. Besides, the circulating levels of pro-inflammatory cytokines were notably decreased, indicating the blocked transfer of inflammatory cytokine from gut via blood.Conclusion Probiotics protect dopaminergic neurons in PD mice by attenuating the neuroinflammation via inhibiting the intestinal inflammation, which is acquired by restoring the imbalanced gut microbial composition, providing evidence for the idea of targeting the intestinal inflammation as well as using probiotics for PD treatment.
Evaluation of expression of genes associated with post-thrombotic syndrome
Authors: Barros Ricardo André Viana , Herenio Erika Mota , Maximiano Mariana Rocha , Ribeiro Julia Hellena Mendes , Franco Octávio Luiz , Pogue Robert 
Published: May 2023

Abstract
The prediction of post-thrombotic syndrome (PTS) development among patients with deep venous thrombosis (DVT) is currently based on clinical characteristics alone; reliable biomarkers are unavailable. In this study, the expression of myeloperoxidase (MPO), Fms-related tyrosine kinase 4 (FLT4), and coagulation Factor XIII A chain (F13A1) was evaluated to identify novel biomarkers of PTS. F13A1 of the clotting cascade stabilizes the thrombus; MPO interacts with the endothelium; and FLT4 encodes a vascular endothelium-derived growth factor receptor that participates in angiogenesis. This study evaluated nine patients stratified into three different groups. The control group included three healthy patients; the second group included three patients with DVT without PTS (group II); and the third group included three patients with PTS (group III). The expression of MPO, FLT4, and F13A1 was evaluated in the three groups. A significant decrease in FLT4 expression (ΔCt -2.71; gene expression 0.03, p=0.11 in group II; ΔCt -2.44; gene expression 0.01, p=0.05 in group III) and a non-significant difference in MPO gene expression were found among the three groups; however, there was a notable progressive increase in F13A1 expression (ΔCt 6.54; gene expression 3.5, p=0.02). Despite the low sampling rate in the present study, the decreased FLT4expression and increased of F13A1 expression may represent biomarkers of PTS.
Learning from an Experience, Challenges and Approaches in the Workplace during COVID-19 Pandemic: A Content Analysis of International Documents
Authors: Ghayen Masoud Motalebi , Faghihi Mitra , Ezati Elahe , Khosravi Yahya , Almasi Ali , Farshad Ali Asghar , Hassanzadeh-Rangi Narmin , Shirzadi Shayesteh 
Published: May 2023

AbstractBackground The present study aims to investigate international measures of pandemic control at the workplace based on the guidelines of international organizations and learn from them and their experiences. Methods We conducted the qualitative study through the content analysis method. The search method included the guidelines published regarding the prevention and response in dealing with the COVID-19 pandemic in workplaces. Results We extracted eleven categories, consisting of legal requirements and duties of employees and employers, structure and program changes, risk assessment, risk communication, information and training, internal and external consultation and cooperation, provision of facilities and tools and workplace hygiene, special conditions, special groups, closing and reopening workplaces, reducing contact and exposure and mental health. Conclusions Protecting employees during a pandemic requires a multifaceted approach and strong advocacy. The operational plan of pandemic control should be developed according to the level of risk, and the support should be appropriate to the conditions of the employees and adapted to their needs.
Wire-EDM performance and surface integrity of Inconel 718 with unique microstructural features fabricated by laser powder bed fusion
Authors: Gokcekaya Ozkan , Günen Ali , Ceritbinmez Ferhat , Bahador Abdollah , Nakano Takayoshi , Çetin Melik 
Published: May 2023

Abstract
Inconel 718 alloy is difficult to machine using conventional methods due to its physical properties. Thereby, additive manufacturing (AM) of IN718 components with near-net shapes has been excessively studied. Even though AM processes provide shape and size accuracy, there is still the need for the machining of the AM-processed components. Laser powder bed fusion (LPBF) has been successfully utilized to fabricate near-net shape IN718 components, moreover, the microstructure of LPBF-IN718 was unique owing to the AM processing, resulting in differences in grain size, grain boundary characteristics, and grain orientations. Furthermore, these microstructural characteristics are expected to alter the machining performance of IN718. Therefore, this study investigated the wire electro-discharge machining (WEDM) performance of LPBF-718 samples compared to wrought IN718 while focusing on the unique microstructure characteristics of LPBF-IN718 samples (lamella, single-crystal, ploy-crystal). Three different cutting strategies (rough, semi-finish, and finish) were implemented to understand the performance of the multi-pass cutting phenomenon and its effect on the surface of IN718. For all samples, rough (single pass) cutting displayed high roughness while finish (three passes) cutting exhibited good surface quality. Compositional analyses on the machined surface showed debris formation including Zn and Cu-containing recast material, indicating wire erosion. The surface of single-crystal LPBF-IN718 after the WEDM process was smooth owing to its big grain size and less amount of grain boundary, resulting in slow cutting speed but a good surface finish. Thus, this study, for the first time, investigated the effect of unique microstructural characteristics of LPBF-fabricated IN718 on WEDM performance and machined surface quality.
Identification of Age-Related Characteristic Genes Involved in Severe COVID-19 Infection Among Elderly Patients using Machine Learning and Immune Cell Infiltration Analysis
Authors: Li Huan , Zhao Jin , Xing Yan , Chen Jia , Wen Ziying , Ma Rui , Han Fengxia , Huang Boyong , Wang Hao , Li Cui , Chen Yang , Ning Xiaoxuan 
Published: May 2023

Abstract

Background Elderly patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are at higher risk of severe clinical manifestation, extended hospitalization, and increased mortality. Those patients are more likely to experience persistent symptoms and exacerbate the condition of basic diseases with long COVID-19 syndrome. However, the molecular mechanisms underlying severe COVID-19 in the elderly patients remain unclear. Our study aims to investigate the function of the interaction between disease-characteristic genes and immune cell infiltration in patients with severe COVID-19 infection.Methods COVID-19 datasets (GSE164805 and GSE180594) and aging dataset (GSE69832) were obtained from the Gene Expression Omnibus (GEO) database. The combined different expression genes (DEGs) were subjected to Gene Ontology (GO) functional enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Diseases Ontology (DO) functional enrichment analysis, Gene Set Enrichment Analysis (GSEA), machine learning, and immune cell infiltration analysis.Results GO and KEGG enrichment analysis revealed that the eight DEGs (IL23A, PTGER4, PLCB1, IL1B, CXCR1, C1QB, MX2, ALOX12) were mainly involved in inflammatory mediator regulation of TRP channels, coronavirus disease-COVID-19, and cytokine activity signaling pathways. Two-degree algorithm (LASSO and SVM-RFE) and correlation analysis showed that the seven DEGs upregulated the immune cells of macrophages M0/M1, memory B cells, gramma delta T cell, dendritic cell resting and master cell resisting.Conclusion Our study identified seven hallmark genes that can serve as disease-characteristic genes and target immune cells infiltrated in severe COVID-19 patients among the elderly population, which may contribute to the study of pathogenesis and the evaluation of diagnosis and prognosis in aging patients infected with severe COVID-19.
Adsorption equilibria and kinetics of CO2, CH4, and N2 on activated carbon and carbon molecular sieve
Authors: chen Si'ang , Wu Wenling , Niu Zhaoyang , Kong Deqi , Li Wenbin , Tang Zhongli , Zhang Donghui 
Published: May 2023

Abstract
Flue gas and coal bed methane are two important sources of greenhouse gases. Pressure swing adsorption process has a wide range of application in the field of gas separation, and the selection of adsorbent is crucial. In this regard, in order to assess the better adsorbent for separating CO2 from flue gas and CH4 from coal bed methane, adsorption isotherms of CO2, CH4 and N2 on activated carbon and carbon molecular sieve are measured at 303.15, 318.15, and 333.15 K, and up to 250 kPa. The experimental data fits better with Langmuir 2 compared to Langmuir 3 and Langmuir-Freundlich models, and Clausius-Clapeyron equation was used to calculate the isosteric heat. Both the order of the adsorbed amount and the adsorption heat on the two adsorbents are CO2 > CH4 > N2. The adsorption kinetics are calculated by the pseudo-first kinetic model, and the order of adsorption rates on activated carbon is N2 ≥ CH4 > CO2, while on carbon molecular sieve it is CO2 ≥ N2 > CH4. It is shown that relative molecular mass and adsorption heat are the primary effect on kinetics for activated carbon, while kinetic diameter is the main resistance factor for carbon molecular sieve. Moreover, the adsorption selectivity of CH4/N2 and CO2/N2 were estimated with the ideal adsorption solution theory, and carbon molecular sieve performed best at 318.15 K for both CO2 and CH4 separation. Overall, the study suggested that carbon molecular sieve is a better option for separating flue gas and coal bed methane.