bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization and Characterization of Flavipin Produced by Aspergillus Terreus
Authors: Qasim Mohammed Jasim 
Published: April 2023

The secondary metabolites of microorganisms serve as defence or signalling molecules in ecological interactions, revealing substantial survival benefits in nature. As a result, many researchers have concentrated on screening and optimizing the production of these molecules from natural sources such as microorganisms with the objective of pharmacological uses, primarily as antibiotics or anticancer agents. In this study, 80 isolates of Aspergillus were investigated for the production of flavipin. These fungi were collected from various locations and laboratories. Flavipin was estimated by using a standard curve, then purified by using silica gel chromatography, followed by identification using thin layer chromatography (TLC), and High Performance liquid chromatography (HPLC). The fermentation conditions were carried out at the Central Health Laboratory/Maysan Health Directorate from April 2021 to August 2022. Out of eighty isolates of Aspergillus, only one isolate was identified as producer of flavipin which was Aspergillus terreus. According to HPLC analysis, the retention times of flavipin and its standard were 7.7 minutes and 7.6 minutes, respectively. By using the TLC technique, the relative flow (Rf) value was 0.55 cm for both standard flavipin and flavipin. The optimization of growth conditions and production of flavipin were studied. It is revealed that optimum conditions were as follows: pH 7 on 16 days, the temperature of 25oC for 12 days, culture volume of 50 ml on the 16th day, shaking speed of 150 rpm on the 12th day, inoculum size of 8 fungal agar disc on the 12th day, the optimal incubation period of 14 days, and Potato Dextrose Broth as the optimal culture media. The aim of the study was to determination of optimal conditions for the flavipin production that produced by Aspergillus terreus. For yielding a profuse amount of flavipin, the incubation and fermentation conditions such as temperature, the culture volume, shaking speed, inoculum size, pH of the medium, incubation period, and the type of culture media should be considered and the optimal one must be chosen.
Isolation, Identification and Antibacterial Activity of Alkaloid Compound N-Methylcytisine from Cyanobacterium Hapalosiphon Aureus
Authors: Al-Mousawi Nida J. M. , Al-Assadi Iqbal J. , Al-Aarajy Moussa J. 
Published: April 2023

In this study, one species of algae, belongated to cyanophyta : Hapalosiphon aureus west and west 1897 were isolated, identified and purified. The extracts of algal isolates were testing to clarify their ability on growth inhibition on each of gram +ve and gram –ve bacteria E.coli & S. aureus, filamentous fungi A. fumigatus, and yeasts C.albican. The extracted alkaloid of species H.aureus showed higher inhibition activity. In our literature survey, the alkaloid compound analog N- methylcytisine was isolated for the first time from the H.aureus . This compound was characterized using Thin Layer Chromatography (TLC), Ultra Violet Spectrum (UV), Infrared Spectrum (IR), Proton Nuclear Magnetic Resonance Spectroscopy (1HNMR), Melting Point and Solubility in organic and inorganic solvents. The biological activity of this alkaloid was determined using the Minimal Inhibitory Concentration (MIC) against six bacterial isolates. The results showed inhibition in 33.3% growth of bacteria on 150 μg/ml concentration level, while the MIC against six fungi isolates showed inhibition of growth 33.3% at 50 μg/ml compared to standard antibiotic. The median lethal dose (LD50) showed no toxicity, no cytotoxicity and no effect on human red blood cells for 18 hours.
Good coverings of proximal Alexandrov spaces. Path cycles in the extension of the Mitsuishi-Yamaguchi good covering and Jordan Curve Theorems
Authors: Peters James Francis , Vergili Tane 
Published: April 2023

This paper introduces proximal path cycles, which lead to the main results in this paper, namely, extensions of the Mitsuishi-Yamaguchi Good Coverning Theorem with different forms of Tanaka good cover of an Alexandrov space equipped with a proximity relation as well as extension of the Jordan curve theorem. In this work, a path cycle is a sequence of maps h1,...,hi,...,hn-1 mod n in which hi : [ 0,1 ] → X and hi(1) = hi+1(0) provide the structure of a path-connected cycle that has no end path. An application of these results is also given for the persistence of proximal video frame shapes that appear in path cycles.
Simulation of Dynamic Processes in the Human Body using Differential Equations with Discontinuous Right-Hand Side
Authors: Горбунов Д. В. , Гавриленко Т. В. 
Published: April 2023

в работе рассматривается задача математического моделирования функциональных систем организма человека в рамках исследований динамики изменения параметров подсистем с хаотической, самоорганизующейся структурой. Данная задача является актуальной ввиду необходимости изучения взаимодействия подсистем сложной системы организма человека, в том числе поиска причин возникновения патологических процессов. Разработанные методы математического моделирования на основе дифференциальных уравнений с разрывной правой частью позволяют учитывать процесс самоорганизации динамических подсистем. Задача удержания стационарного состояния базируется на приближении решений к уникальной линии разрыва системы, что позволяет эффективно воспроизводить динамику подсистемы организма человека. В свою очередь, линия разрыва генерируется в процессе моделирования и корректируется в зависимости от текущего состояния подсистемы и стационарного состояния, что существенно приближает к динамике реальной живой системы. Также в работе представлены результаты применения метода математического моделирования на примере работы биомеханической системы человека (частный случай). Апробация показала высокую адекватность метода математического моделирования и эффективность численного решения на основе сравнительного анализа результатов моделирования и данных натурных экспериментов. Результаты расчетов динамики движений биомеханической системы показали устойчивость на серии вычислительных экспериментов.
this study considers the simulation of the human body’s functional systems as part of the research into the parameter variation dynamics in subsystems with a chaotic, self-organizing structure. The problem is significant as we need to study the interaction between the subsystems of a complex system, the human body, and find the causes of pathologies. The proposed simulation method uses differential equations with a discontinuous right-hand side. It enables us to account for self-organization in dynamic subsystems. The stationary state is maintained as the solution approaches a unique discontinuity line in the system, as it correctly reproduces the dynamics of a subsystem in the human body. The discontinuity line is generated during the simulation and adjusted to match the current state of the subsystem and the stationary state, which is a much better representation of the dynamics of a real living system. The paper includes the simulation results of a human biomechanical system (a special case). The tests proved the simulation results are in good agreement with the experiments. The biomechanical system motion simulation results show stability in a series of computational experiments.
Approaches to the Simulation of Personal Income Variations During Epidemics
Authors: Петракова В. С. , Криворотько О. И. 
Published: April 2023

в статье предлагаются две модели, описывающие влияние динамики распространения вируса на такие макроэкономические показатели, как численность рабочей силы и уровень среднедушевого дохода населения. Первая предложенная модель объединяет камерный подход SIR к моделированию распространения эпидемий и урбанистическую модель Лотки-Вольтерры. Вторая обобщает предложенную дифференциальную модель на задачу оптимального управления. Приведено сравнение результатов моделирования между собой и реальными данными на примере Новосибирской области за 2020–2021 гг. Для модели оптимального управления предложено несколько сценариев, которые могут быть использованы при расширении модели для моделирования отличной от рассматриваемой экономико-эпидемиологической ситуации.
this study proposes two models representing the impact of the virus spread on such macroeconomic metrics as the labor force size and per capita income. The first model combines the SIR compartmental epidemics modeling and the Lotka-Volterra model. The second one extends the proposed differential model to the optimal control problem. The simulation results are compared with each other and real-world data for the Novosibirsk Region, 2020–2021. We used several scenarios for the optimal control model to further expand the model to other economic and epidemiological conditions.
Implicit Communities Defined on the Graph for Interacting Objects
Authors: Чеповский А. А. 
Published: April 2023

в работе рассматриваются текущие и перспективные задачи анализа графов, представляющих сложные сети взаимодействующих объектов. Описаны предметные области, для которых актуальны данные модели, рассматриваются практика, проблемы анализа графов социальных сетей и выделения на них неявных сообществ. Обсуждаются основные алгоритмы выделения сообществ на графах и проблема тестирования качества получаемых разбиений. Автором предложены перспективные, на его взгляд, направления развития данной тематики для графов, полученных при импорте данных из реальных социальных сетей. Показана актуальность подходов, предложенных в предыдущих работах автора.
the paper considers the problems of analyzing graphs that represent complex networks of interacting objects. The relevant domains are described, social network graph analysis and implicit community detection are considered. The key graph-based community detection algorithms and the quality assessment of their results are discussed. The author proposed promising development trends using the graphs representing actual social networks. The relevance of the approaches proposed in the author’s previous works is also highlighted.
Spectral Processing of Acoustic Signals for Pipeline Security Systems
Authors: Романовский М. В. , Солдатов А. И. 
Published: April 2023

в статье приведен обзор существующих систем физической защиты магистральных трубопроводов от несанкционированного действия. Показано, что наиболее перспективной будет схема охраны с акустическим датчиком и оптико-электронной системой распознавания, действующая по алгоритму: срабатывание акустического датчика — подтверждение по акустическому алгоритму — подтверждение оптико-электронной системой наблюдения — тревога. В основе распознавания акустических сигналов использован метод прямого преобразования Фурье для определения частотного спектра акустических сигналов и сравнения их с эталонными. Вышеупомянутый метод прямого преобразования основан на разложении суммарных акустических сигналов, улавливаемых датчиком, на исходные синусоиды. Данная работа направлена на модернизацию системы физической защиты по отношению к магистральным трубопроводам по доставке нефтепродукта и как следствие — к повышению уровня защищенности таких объектов. Предлагаемый метод модернизации системы физической защиты позволит обеспечить условия для однозначного определения несанкционированных действий путем анализа и сопоставления звукового сигнала с базой сигналов предварительно записанных звуков и решить ряд проблем актуальной темы обеспечения безопасности и сохранности линейных магистральных нефтеи газо-трубопроводов. Также такое решение позволит минимизировать частоту ложных срабатываний технических средств физической защиты.
this paper is an overview of the existing pipeline security systems preventing unauthorized access to the pipe. It is shown that the most suitable solution is an acoustic sensor and optoelectronic recognition system. It operates as follows: the acoustic sensor is activated – the acoustic algorithm confirms the alarm – the optoelectronic system confirms the alarm – the alarm is triggered. The direct Fourier transform is used for acoustic signal recognition to identify the frequency spectrum of acoustic signals and compare it with the reference one. The above-mentioned direct transform includes a decomposition of the total acoustic signal from the sensor into original sinusoids. The purpose of this study is to upgrade the oil pipeline security systems for better efficiency. The proposed upgrade method unambiguously identifies any unauthorized access by analyzing and comparing the audio signal with the reference signal from a database of pre-recorded sounds to protect oil and gas pipelines. The solution also minimizes the false alarm rate.
ANALISIS PEMBERIAN REWARD DAN PUNISHMENT PESERTA DIDIK DALAM PENINGKATAN MUTU PENDIDIKAN
Authors: Sahade Sahade , Rijal Syamsu 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui: 1) pengaruh pemberian reward dan punishment secara parsial dan secara simultan terhadap peningkatan mutu pendidikan dan 2) variabel yang pengaruhnya dominan terhadap peningkatan mutu pendidikan. Variabel dalam penelitian ini adalah reward sebagai variabel bebas pertama (X1), punishment sebagai variabel bebas kedua (X2) dan mutu pendidikan sebagai variabel terikat (Y). Populasi dalam penelitian ini yaitu seluruh peserta didik di SMK Negeri 1 Makassar yang berjumlah 1400 peserta didik yang terdiri atas 415 peserta didik laki-laki dan 985 peserta didik perempuan dengan jumlah rombel sebanyak 40. Teknik pengambilan sampel menggunakan teknik purposive sampling, sampel berdasar kepentingan dan keterbatasan sehingga mengambil 5% dari keseluruhan populasi yaitu 70 peserta didik. Teknik pengumpulan data yang digunakan dengan menggunakan kuesioner dan data dokumen sekolah yang relevan. Teknik analisis data menggunakan analisis deskriptif kuliatatif dengan persentase, uji instrumen, uji asumsi klasik dan uji hipotesis. Uji instrumen terdiri dari uji validitas dan uji reliabilitas. Uji asumsi klasik terdiri dari uji normalitas, uji multikolinieritas, uji autokorelasi dan uji heteroskadastisitas.Uji hipotesis terdiri dari regresi linear berganda, uji simultan (uji F), koefisien determinasi ganda (R2), uji parsial (uji t) dan koefisien determinasi parsial (r2). Hasil penelitian ini menunjukkan bahwa pemberian reward secara parsial berpengaruh signifikan terhadap terhadapa peningkatan mutu pendidikan dengan tingkat signifikan <0,05 dan punishment secara parsial berpengaruh signifikan terhadap mutu pendidikan dengan tingkat signifikan <0,05. Pemberian reward dan punishment secara simultan berpengaruh signifikan terhadap mutu pendidikan dengan tingkat signifikan <0,05, dan koefisien determinasi (R^2) yaitu sebesar 0,547 (54,7%) yang berarti bahwa pengaruh reward dan punishment terhadap mutu pendidikan adalah sebesar 54,7% sedangkan sisanya 45,3 dipengaruhi oleh faktor yang belum diteliti.
PENGARUH MODEL BLENDED PROBLEM BASED LEARNING BERBASIS LMS MOODLE TERHADAP MOTIVASI BELAJAR DAN HASIL BELAJAR MAHASISWA JURUSAN AKUNTANSI
Authors: Fakhri M. Miftach , Wahid Anwar , Fadhilatunisa Della , Surianto Dewi Fatmarani , Fajar B Muhammad , Hidayat Akmal 
Published: April 2023

Penelitian ini bertujuan untuk: mengetahui model blended problem-based learning berbasis LMS Moodle yang berpengaruh dalam meningkatkan hasil dan motivasi belajar mahasiswa dan perbedaan hasil dan motivasi belajar mahasiswa yang diberikan pembelajaran model blended problem-based learning berbasis LMS Moodle dengan mahasiswa yang mengikuti model blended learning. Desain penelitian yang dilaksanakan yaitu eksperimental semu (quasi experimental). Sampel penelitian terdiri dari kelas A yakni 34 orang dalam kelas eksperimen dan kelas D yakni 33 orang dalam kelas kontrol. Teknik pengambilan sampel yaitu purposive sampling. Hasil penelitian menjelaskan yaitu hasil análisis inferential dengan uji paired simple t test menjelaskan nilai t-hitung lebih besar dibandingkan t-tabel dengan nilai sig lebih kecil daripada 0.05 yang bermakna yaitu pelaksanaan model blended problem-based learning dapat membantu peningkatan hasil dan motivasi belajar mahasiswa. Selain itu, hasil dari uji independent simple t test menjelaskan yaitu nilai t-hitung lebih besar dibandingkan t-tabel dengan nilai sig lebih kecil daripada 0.05 yang bermakna yaitu hasil dan motivasi belajar mahasiswa kelas eksperimen mempunyai perbedaan secara signifikan dengan mahasiswa kelas kontrol.
Xử lý phế phẩm khóm tắc cậu với rơm bằng phương pháp lên men và tái sử dụng làm thức ăn cho gia súc nhai lại
Authors: Nguyễn Ngọc Trang 
Published: April 2023

Nghiên cứu xử lý phế phẩm khóm Tắc Cậu lên men với rơm làm thức ăn cho gia súc nhai lại và phân tích các yếu tố ảnh hưởng đến nhu cầu thức ăn lên men cho gia súc nhai lại. Thí nghiệm bố trí 4 nghiệm thức và 4 lần lặp lại, các nghiệm thức gồm 30%, 45%, 60% và 75% với mỗi túi 2 kg sản phẩm; đánh giá cảm quan, pH và NH3 vào 0, 7, 14, 21 và 28 ngày. Thực hiện phỏng vấn hộ dân để phân tích yếu tố ảnh hưởng nhu cầu thức ăn lên men.
Kết quả cho thấy sau 28 ngày, nghiệm thức 75% vỏ khóm ủ chua đạt mức chất lượng tốt với giá trị pH là 4,03 và NH3 là 166 (mg/kg vật chất khô). Mô hình hồi quy tuyến tính đa biến được xây dựng nhằm xác định yếu tố ảnh hưởng đến nhu cầu sử dụng thức ăn lên men (P<0,05; R2 điều chỉnh là 0,767). Sự quan tâm đến nguồn gốc thức ăn của các hộ dân là yếu tố quan trọng ảnh hưởng đến nhu cầu thức ăn lên men (Beta = 0,468). Sản phẩm lên men từ phế phẩm khóm và rơm ở nghiệm thức 75% (NT75%) có thể tận dụng làm nguồn thức ăn cho gia súc nhai lại.
Pengaruh Kepemimpinan Transformasional dan Manajemen Tata Usaha terhadap Kinerja Kependidikan di MAN 2 Kota Malang
Authors: Maysaroh Ferliana , Abidin Munirul , Sholeh Lukman , Rohman Ahmad Roisur , Haikal Imam Fikri , Wasilah Nur 
Published: April 2023

Kepemimpinan transformasional dan manajemen TU merupakan sebuah elemen yang saling berhubungan jika dipandukan untuk peningkatan dan kinerja tenaga kependidikan. Sesuai dengan beberapa penemuan penelitian gaya transformasional sangat dibutuhkan untuk kualitas kerja pegawai sehingga pada manajemen TU akan mendukung peningkatan kerja dengan manajemen yang diterapkan di MAN 2 Kota Malang. Tujuan dari penelitian ini untuk mengetahui pengaruh kepemimpinan transformasional dan manajemen TU terhadap kinerja tenaga kependidikan di MAN 2 Kota Malang. Penelitian ini menggunakan metode kuantitatif dengan jenis peenelitian deskriptif dan verifikatif. Dengan sampel penelitian sebanyak 30 responden yang merupakan tenaga kependidikan di MAN 2 Kota Malang. Berdasarkan pengujian secara koefisisen Determinasi (R2) ditemukan hasil 24,9% pada X1 ke Y dan pada X2 ke Y hasilnya 0,03%. Dan untuk Uji t dari H1 0,006 <0,05 dan nilai t hitung 2,990 > t tabel 2,052 yang artinya berpenagruh, dari H2 sebesar 0,808 > 0,05 dan nilai t hitung -0.241 < t tabel 2,052 tidak berpengaruh dan untuk Uji F H3 nilai 4,516 > F tabel 3,34 dikatakan secara simultan berpengaruh.
Law Enforcement Against the Crime of Drinking Alcohol in the Jurisdiction of Labuhanbatu Police Station
Authors: Maisyah Alfiqri , Kusno Kusno , Siregar Ahmad Ansyari 
Published: April 2023

Basically, a legal norm is part of the legal system, to apply an article in the Criminal Code (KUHPidana). This study aims to find out and analyze law enforcement against criminal offenders of explosive and circulating liquor. As well as knowing and analyzing the modus operandi of criminal offenders of exploiting and distributing liquor. This research belongs to the normative type of research. So it can be known that the modus operandi of the perpetrator of bootleg liquor is put in plastic wrap and sold secretly. Another motive of the perpetrator is due to economic factors and cultural factors. Based on the explanation above, it can be concluded that the modus operandi of the bootleg liquor perpetrator is put in plastic wrap and sold secretly. Another motive of the perpetrator is due to economic factors and cultural factors.
The Juridical Review on the Misappropriation of Foundation Funds is Reviewed Based on Law of the Republic of Indonesia Number 8 of 2010 Concerning the Prevention and Eradication of Money Laundering
Authors: Siregar Ahmad Bukhori , Kusno Kusno , Siregar Ahmad Ansyari 
Published: April 2023

This study aims to find out and analyze the criminal act of embezzlement in educational foundations. As well as knowing and analyzing the factors of embezzlement in the foundation. This research belongs to the normative type of research. So it can be seen that it can be concluded that the Criminal Linkage can clearly be seen in Article 2 paragraph (1) of Law Number 8 of 2010 concerning the Prevention and Eradication of Money Laundering. Predicate crime is a crime that triggers (source) the occurrence of money laundering crimes, so the handling of money laundering cases has an important meaning for the return of state assets related to the eradication of corruption.
The Authority to Manage Goods Confiscated by the State is Reviewed According to Government Regulation Number 27 of 2014 Concerning Management of State/Regional Property
Authors: Sihombing Donald Adrian , Sriono Sriono , Kusno Kusno 
Published: April 2023

This study aims to know and analyze, know and analyze the scope of management of State property. As well as knowing and analyzing the provisions of legislation related to the Indra Kenz case. This research belongs to the normative type of research. So it can be seen that in article 1 paragraphs (1) and (2) it is said in one pointnyes that other legitimate acquisitions can be based on court decisions that have obtained permanent legal force, for example is State Booty/Confiscation. In addition, the implementation of criminal law functions in the Indra Kenz case has been implemented properly and in accordance with what was expected in the Preamble to the 1945 Constitution.
HUBUNGAN PENDIDIKAN KESEHATAN, DUKUNGAN SUAMI DAN PERAN PLKB TERHADAP MINAT PENUNDAAN KEHAMILAN PADA WANITA USIA DIBAWAH 20 TAHUN DI KECAMATAN TOBOALI BANGKA SELATAN TAHUN 2022
Authors: Hanun Lutfia Caesar , Hayatullah Madinah Munawaroh , Hodijah Siti 
Published: April 2023

Pendahuluan: Minat penundaan kehamilan didefinisikan sebagai suatu keinginan terorganisir yang mendorong serangkaian usaha yang dilakukan secara sengaja oleh pasangan perkawinan yang dapat mengakibatkan tertundanya kehamilan. Di Indonesia pada tahun 2018 satu dari sembilan anak perempuan menikah.. Metode : deskriptif analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini ialah 36 jiwa dengan teknik random sampling untuk pengambilan sampel sehingga didapati sampel sebanyak 33 jiwa. Hasil dan Pembahasan : Menunjukkan ada hubungan signifikan antara pendidikan kesehatan dengan minat penundaan usia kehamilan diperoleh nilai p value 0,032, dukungan suami dengan minat penundaan usia kehamilan diperoleh nilai p value 0,042 dan peran PLKB dengan minat penundaan usia kehamilan diperoleh nilai p value 0,034.. Kesimpulan : Diharapkan untuk wanita usia < 20 tahun yang sudah menikah dan belum hamil untuk dapat terlibat dalam penyuluhan guna meningkatkan pengetahuan dan mengikuti program KB hingga berada di umur yang siap untuk hamil.