bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arterial pressure during first day after intravenous thrombolysis and acute ischemic stroke outcomes: single-center randomized controlled study
Authors: Avidzba A. R. , Saskin V. A. , Nikonov A. M. , Ayyaz H. , Kirov M. Yu. 
Published: January 2025

Introduction. Blood pressure optimization during and after reperfusion in patients with acute ischemic stroke can reduce the risk of hemorrhagic complications and improve functional recovery. Several randomized controlled trials of different target blood pressure values have been published with varying results.The objective was to evaluate the effect of intensive hypotensive therapy in the first day after intravenous thrombolysis on outcomes of acute ischemic stroke and incidence of complications.Materials and methods. A single-center open label randomized controlled trial was conducted. Patients older than 18 years with acute ischemic stroke who underwent reperfusion were included. Patients were randomized into 2 groups: with a target systolic blood pressure of 161–185 mm Hg on the first day (control group) versus < 160 mm Hg (intensive hypotensive therapy group). The primary end points were mortality and modified Rankin Scale score at day 90 from the onset of stroke.Results. The final analysis included 69 patients. In the intensive hypotensive therapy group, mortality rate did not differ from the control group: OR 1.1 [95% CI 0.3 to 4.8] (p = 0.896). The median modified Rankin scale score at day 90 in the control group was 2 (1; 3.8) versus 2 (1; 3.5) in the intensive hypotensive therapy group (p = 0.812).Conclusion. Intensive hypotensive therapy at the first day after intravenous thrombolysis in acute ischemic stroke patients with target values of systolic blood pressure < 160 mm Hg compared to conventional values of 161–185 mm Hg neither improved functional outcome nor decreased mortality and complications rate on day 90 from the onset of stroke.
Septic shock in the intensive care unit of a multidisciplinary hospital
Authors: Plotkin L. L. , Artamonov V. A. 
Published: January 2025

The objective of the study was to assess the prevalence, etiology, and outcomes of intensive care in patients with septic shock in the ICU of a multidisciplinary hospital.Materials and methods. A single-center, retrospective, cohort study was conducted involving 398 patients with septic shock who were hospitalized in the ICU over a one-year period. Diagnosis of septic shock, as well as a complex of intensive care, were carried out according to the criteria proposed by the recommendations of the Surviving sepsis campaign (2021). Antibacterial therapy was prescribed based on the Guidelines «Diagnosis and antimicrobial therapy of infections caused by multidrug-resistant strains of microorganisms» (2022)Results. The proportion of patients with septic shock was 7.4% of the entire population hospitalized in the ICU. The hospital mortality rate was 25%. The dominant loci of infection in patients with septic shock were the abdominal cavity (33%) and lungs (32.4%). The microbial landscape was dominated by gram-negative flora (66%), among which in 35% of cases, Klebsiella pneumoniae was characterized by resistance to the antibacterial drugs used. Combined antibacterial therapy was received by 84% of patients.
Information technologies and key components for ensuring patient safety in anesthesiology and intensive care units with different levels of digitalization (message 3)
Authors: Gorban V. I. 
Published: January 2025

The objective was to assess the relationship between the implementation of information technologies in the work of anesthesiology and intensive care services of multidisciplinary hospitals and the severity of the leading components of patient safety at different levels of digitalization.Materials and methods. Expert assessment of the level of digitalization and the effectiveness of using new medical information technologies in the system of the anesthesiology and intensive care service (department) of 235 multidisciplinary hospitals, including an assessment of the leading components of patient safety at different levels of digitalization. Statistical analysis of data distribution, Student’s t-test for independent samples.Result. It has been established that the majority (47.7%) of anesthesiology and intensive care units (AICU) of multidisciplinary hospitals in the Russian Federation are at the average (sufficient) level of digitalization. Relatively few (19.2%) AICU of multidisciplinary hospitals are at a high and sufficiently high level in terms of digitalization. At the same time, each of the levels of digitalization of the AICU of multidisciplinary hospitals has a close relationship with the severity of the main components of ensuring the safety of patients in the departments.Conclusion. Comparison (correlation) of the level of digitalization and components of patient safety of the AICU of multidisciplinary hospitals showed their fairly close and direct relationship. The study confirms that the effectiveness of ensuring patient safety of the AICU of multidisciplinary hospitals is associated, first of all, with a high level of digitalization as an important integral process for ensuring the quality of specialized medical care.
The role of regional anesthesia techniques in the treatment of lumbosacral plexopathy after aorto-femoral bifurcation prosthetics (clinical case)
Authors: Paromov K. V. , Svirskii D. A. , Neledova L. A. , Kirov M. Yu. 
Published: January 2025

The objective was to demonstrate the effectiveness of regional anesthesia techniques in the treatment of ischemic lumbosacral plexopathy after vascular surgery.Introduction. The frequency of ischemic complications after infrarenal aortic surgery is less than 1%. The persistence and severity of neurological symptoms, as well as the low effectiveness of therapy, can negatively affect the result of surgical intervention.Materials and methods. A 66-year-old patient on the first day after an elective simultaneous aorto-femoral bifurcation prosthetics and cholecystectomy due to an aneurysm of the infrarenal aorta and calculous cholecystitis under inhalation anesthesia had symptoms of left-sided lumbosacral plexopathy, manifesting with left-sided inferior monoplegia, mosaic sensitivity disorders and severe pain syndrome.Results. During routine pain therapy (acetaminophen, nonsteroidal anti-inflammatory drugs, opioids), on the second day after surgery, a transverse abdominis plane block (TAP-block) on the right side and pericapsular nerve group block (PENG-block) on the left side were performed, that led to a rapid regression of acute postoperative pain and restoration of patient mobility. On the 7th, 11th and 16th days after surgery, neurotrophic therapy and comprehensive rehabilitation were supplemented with interventional pain therapy techniques, which provided not only effective pain relief, but also rapid improvement of neurological symptoms. On the 22nd day of postoperative period, the patient was discharged from the hospital with slight motor deficit in the left leg.Conclusions. The case describes complicated course of the postoperative period after aorto-femoral bifurcation prosthetics and cholecystectomy and effectiveness of the interventional therapy for lumbosacral plexopathy of ischemic origin. This strategy led to a rapid regression of neurological deficit in parallel with relief of acute postoperative pain and expansion of rehabilitation opportunities.
Evaluation of the efficacy of enteral therapy in a patient with posttraumatic pancreatitis (clinical case)
Authors: Zhigalova M. S. , Kiselev V. V. , Petrikov S. S. , Yartsev P. A. , Ryk A. A. , Teterin Yu. S. , Shavrina N. V. , Selina I. E. , Rogal M. M. , Staleva K. V. 
Published: January 2025

Introduction. In the development of post-traumatic pancreatitis, an important role is played by microcirculatory disorders, developing against the background of inflammation and decreased capillary blood flow not only in the tissues of the pancreas, but also in other organs, including the intestine, which leads to neuroendocrine dysregulation, dysfunction and/or death of intestinal epithelial cells, disruption of the motor and evacuation functions of the intestine, and, as a consequence, the development of intestinal insufficiency syndrome.The objective was to demonstrate the effectiveness of enteral therapy in a patient with a closed abdominal injury, liver injury and posttraumatic pancreatitis.Materials and methods. We analyzed a clinical case of hospitalization of patient K., 38 years old, with the following diagnosis: “Closed abdominal trauma. Liver trauma of the S6 segment. Hemoperitoneum 1000 ml. Complication: right-sided segmental pneumonia. Bilateral hydrothorax. Posttraumatic pancreatitis”. The patient was admitted with complaints of upper abdominal pain and nausea two weeks after blunt abdominal trauma. She was treated as an outpatient. During the last two days she started to notice nausea, increased pain syndrome in the right side and upper parts. She was brought by an ambulance. Hybrid surgical intervention was performed: endovascular celiacography, superselective embolization of the right hepatic artery branch and diagnostic videolaparoscopic sanation and drainage of the abdominal cavity. In the postoperative period, treatment was performed according to the National Clinical Guidelines, supplemented with enteral therapy.Conclusion. This clinical observation demonstrated the effectiveness of including enteral therapy in a complex of therapeutic measures in the patient with closed abdominal trauma, liver trauma, posttraumatic pancreatitis, which was expressed in a decrease in the level of lactate, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, leukocytes on the 3rd day of dynamic observation. At the same time, an increase in the absolute number of lymphocytes, the concentration of total protein and albumin was noted. The proposed scheme contributed to the regression of signs of intestinal insufficiency syndrome, normalization of intra-abdominal pressure by the 7th postoperative day, prevention of the development of purulent-septic complications and multiple organ failure, a successful outcome of hospitalization.
DESIGN, DEVELOPMENT AND CHARACTERIZATION OF EXTENDED RELEASE MULTIUNIT PARTICULATE SYSTEM OF ANTI-INFLAMMATORY DRUG
Authors: Daslaniya Dhiren , Patel Manish , Shah Amarish 
Published: January 2025

Multi unit particulate system has long been employed to improve the bioavailability of drugs. Mesalamine pellets were prepared by Coating drug solution on sugar sphere followed by various functional coating. The influence of rate controlling membrane made up of Eudragit RSPO and Eudragit RLPO in combination with delay release polymer coating with Eudragit L100 in different proportions on drug release kinetics was studied. Pellets were for the various parameter like Physical characteristics, assay and in-vitro dissolution profile. The study confirmed that mesalamine can be delivered by multi unit particulate system into lower part of intestine. Optimized formulations were evaluated for In-vitro release profile. The optimized formula was stable at accelerated storage condition 40°C / 75 % RH. Prepared Pellets can be used in the treatment of the ulcerative colitis.
DESIGNING AND CHARACTERIZATION OF DRUG FREE PATCHES FOR TRANSDERMAL APPLICATION
Authors: Bharkatiya M. , Nema R. K. , Bhatnagar M. 
Published: January 2025

The present investigation was taken up to prepare and evaluate drug free polymeric patches using different polymers and to study the effect of different plasticizers on physicochemical properties of the patches to explore their feasibility for transdermal application. Polyethylene glycol (PEG 400), Dibutylphthalate (DBP) and Propylene glycol (PG) were used as plasticizers at a concentration of 40 % w/w of dry polymer weight. Drug free polymeric patches were prepared by the casting method on mercury surface and evaluated for weight variation, thickness, flatness, tensile strength, folding endurance, surface pH, hardness, swellability, water vapour transmission rate and skin irritation studies. The mercury substrate method was found to give thin uniform patches.
The weight and thickness of the patches was found to be uniform. Tensile strength and folding endurance of the patches prepared with DBP as plasticizer was high compared to patches plasticized with PG and PEG. All the formulations show 100 % flatness. HPMC K4M: PVP patches plasticized with PEG 400 showed higher swellability and water vapour transmission rates. The patches were found to be free of any skin irritation. Based on the above observations, it can be reasonably concluded that plasticizers have a significant influence on the mechanical properties of the transdermal patches.
Identification of Degradation Pathway of Bilastine and Montelukast by LC/MS
Authors: Markanday Deepanshu , Sharma Chandra Shekhar 
Published: January 2025

It is necessary for a dosage form to maintain their chemical, physical, microbiological and toxicological stability during their entire shelf life. Knowing the intrinsic stability of the chemical and the breakdown pathway of the dosage form is crucial for this reason. We have developed a straightforward analytical approach using HPLC-UV/MS for the simultaneous measurement of Bilastine and Montelukast, as well as the identification of their degradants in tablet formulation. This method is specific, linear, accurate, and robust. The narcotic compounds were broken down one by one. The Zorbax XDB C-18 column (150*4.6) mm, 5µ, with a mobile phase of Water:Acetonitrile:Formic acid (50:50:1), was used to achieve the separation. A flow rate of 1 ml/min was used with an injection volume of 20 µl. A UV-Vis Spectrophotometer was used for peak detection, while a mass spectrophotometer was employed for identification. Bilastine had a retention time of 3.22 minutes and Montelukast of 4.80 minutes. Proposed method was stability indicating, specific, linear, accurate and robust. The degradation pathway was established for Bilastine and Montelukast by studying their degradation in various stress conditions. The Bilastine was found stable in Photolytic and thermal degradation while there was degradation observed in Montelukast in all stress conditions.
PENGUJIAN HIPOTESIS PASAR EFISIEN BENTUK LEMAH DAN PERAMALAN INDEKS HARGA SAHAM GABUNGAN MENGGUNAKAN BOX JENKINS MODEL
Authors: Setiawan Abdurrahman , Mahadewi Lufina 
Published: January 2025

Penelitian ini bertujuan untuk menguji hipotesis pasar efisien bentuk lemah pada indeks harga saham gabungan periode September 2019 sampai Mei 2023 dan meramalkan indeks harga saham gabungan untuk 15 hari kedepan dengan model yang terbaik. Variabel dalam penelitian menggunakan Indeks Harga Saham Gabungan periode September 2019 sampai Mei 2023. Metode pengujian yang digunakan ada dua, yang pertama metode peramalan menggunakan box jenkins model. Proses peramalan dimulai dari identifikasi model (tingkat stasioneritas data, menentukan nilai AR dan MA), estimasi parameter dari model yang terpilih, diagnostic checking, lalu forecasting menggunakan model yang terbaik. Untuk menguji hipotesis pasar efisien menggunakan uji autokorelasi atau durbin watson test. Terkait pengujian hipotesis pasar efisien bentuk lemah terbukti ada di indeks harga saham gabungan dan metode peramalan yang cocok adalah ARIMA (3,1,15) dengan tingkat akurasi 95.23% serta hasil peramalan tidak jauh berbeda dengan data aktual 15 hari kedepan. Implikasi manajerial dari penelitian ini adalah harus berhati-hati dalam proses pengambilan keputusan investasi dan pendanaan di pasar efisien bentuk lemah, karena informasi publik sudah tercermin dalam harga saham. Selain itu, perlu menerapkan strategi manajemen risiko untuk melindungi nilai dari fluktuasi pasar.
E2F1-mediated ESPL1 transcriptional activation predicts poor prognosis and promotes the proliferation of leiomyosarcoma
Authors: Yang Xiaojuan , Miao Guihua , Wang Qin , Yu Qin , Hu Qinsheng , Tan Gang 
Published: January 2025

Objective:
Soft tissue and bone cancers, collectively known as sarcomas, constitute a diverse array of uncommon tumors originating from connective tissues. Among sarcomas, leiomyosarcoma (LMS) is one of the most frequently encountered subtypes. This study aims to investigate the expression, clinical significance, biological regulation, and dysregulation mechanisms of extra spindle pole bodies like 1 (ESPL1), a gene critical for cell cycle regulation in LMS.

Material and Methods:
Bioinformatics analysis was performed using the data from The Cancer Genome Atlas-Sarcoma and Genotype-Tissue Expression datasets. Functional experiments to assess cell proliferation and the cell cycle were performed in LMS cells (SK-LMS-1) after ESPL1 knockdown. Bioinformatics analyses were conducted to identify the potential transcriptional regulators of ESPL1. The regulatory relationship between ESPL1 and the E2F transcription factor 1 (E2F1) was validated through the various molecular assays.

Results:
ESPL1 is significantly overexpressed in LMS compared with normal muscle tissue. High ESPL1 expression is associated with a shorter progression-free interval (PFI) in sarcoma patients, particularly in the LMS subset. ESPL1 expression might be an independent prognostic factor for poor overall survival and PFI in LMS patients. Functional studies in the LMS cell line SK-LMS-1 demonstrated that ESPL1 knockdown slowed cell proliferation and increased G2/M cell cycle arrest, suggesting its crucial role in maintaining LMS cell viability and genomic integrity. Further bioinformatics analysis identified the E2F1 transcription factor as a key regulator of ESPL1 expression in LMS. Mechanistic investigations demonstrated that E2F1 interacts with the ESPL1 promoter, leading to transcriptional activation.

Conclusion:
These findings highlight the ESPL1-E2F1 axis as a potential prognostic biomarker and therapeutic target in LMS.
PENGEMBANGAN INDUSTRI EMPING MELINJO SEBAGAI UPAYA PEMBERDAYAAN MASYARAKAT DI DESA KARANG SARI, KECAMATAN GUNUNG MALIGAS, KABUPATEN SIMALUNGUN, SUMATERA UTARA
Authors: Siregar Hidayati , Tamara Halwa , Pane Mahfuzha , Fatimah Siti , Khairunnisa Lola , Azzahra Lyna Luthfiyyah 
Published: January 2025

<p>Industri emping melinjo merupakan salah satu potensi ekonomi lokal yang dapat dijadikan sebagai upaya pemberdayaan masyarakat di daerah pedesaan. Penelitian ini bertujuan untuk mengkaji pengembangan industri emping melinjo sebagai strategi pemberdayaan masyarakat di Desa Karang Sari, Kecamatan Gunung Maligas, Kabupaten Simalungun, Sumatera Utara. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif melalui studi kasus, dengan fokus pada proses pengembangan industri emping melinjo, dampaknya terhadap ekonomi masyarakat setempat, serta faktor-faktor yang mempengaruhi keberhasilan pengembangan industri tersebut. Metode penelitian melibatkan pengumpulan data melalui observasi partisipatif, wawancara mendalam dengan para petani melinjo dan pelaku industri emping, serta analisis dokumen terkait kebijakan dan program pemberdayaan masyarakat. Hasil penelitian menunjukkan bahwa pengembangan industri emping melinjo di Desa Karang Sari telah memberikan dampak yang positif terhadap pemberdayaan masyarakat setempat. Industri ini telah mampu menciptakan lapangan kerja baru, meningkatkan pendapatan masyarakat, serta memberikan kontribusi terhadap pengembangan ekonomi lokal. Faktor-faktor yang berkontribusi terhadap keberhasilan pengembangan industri emping melinjo meliputi dukungan dari pemerintah daerah dalam bentuk pelatihan dan pendampingan, akses terhadap modal usaha, pengembangan jaringan kerjasama dengan pihak-pihak terkait, serta upaya diversifikasi produk untuk menghadapi fluktuasi pasar. Namun, penelitian juga mengidentifikasi beberapa kendala seperti kurangnya akses terhadap pasar yang luas, keterbatasan teknologi pengolahan yang modern, serta permasalahan dalam manajemen usaha. Dalam konteks pemberdayaan masyarakat, pengembangan industri emping melinjo memberikan gambaran tentang bagaimana potensi lokal dapat dikembangkan secara berkelanjutan untuk meningkatkan kesejahteraan masyarakat pedesaan. </p>
Total Phenolics and Flavonoids Content of Pemphis acidula Leaves Extract, In Vitro Antioxidant and Antidiabetic Activity, and Characterization of The Extract Towards Standardized Antidiabetic Herbal Medicine
Authors: Mardianawati Nurlita , Sulastri Lilik , Sinaga Ernawati 
Published: January 2025

Diabetes mellitus is a prevalent metabolic disorder that still remains a threat to public health all over the world. Oxidative stress is a critical factor in the pathogenesis and progression of diabetes mellitus and its associated complications. Plants contain many antioxidant compounds that can provide protection against free radical-related diseases. The present study aims to evaluate the potential of ethanol extract of Pemphis acidula leaves as antidiabetic agent by measuring its total phenolics and flavonoids content, and its antioxidant and α-amylase inhibitor activity as well. The total phenols content was determined using Follin-Ciocalteu method and total flavonoids content was determined using the AlCl3 colorimetric method, while in vitro antioxidant activity was evaluated using DPPH method. Results of the study showed that ethanol extract of Pemphis acidula leaves contains total phenolics and total flavonoids equivalent to 5390mg GAE/100 grams of extract and 581.66mg QE/100 grams of extract respectively, and it had also been proven that the extract has strong antioxidant and α-amylase inhibitor activity with IC50 of 57.71 ppm and IC50 of 70.05 ppm respectively. From these results, it can be concluded that ethanol extract of Pemphis acidula leaves has the potential as an anti-diabetic agent.
El protocolo como figura para preservar las tradiciones universitarias
Authors: Rubín Ruiz Silvia 
Published: January 2025

Introducción: En una instancia universitaria ocurren un sinfín de actividades que se enmarcan en el quehacer de la comunidad que la compone: estudiantes, profesores, investigadores, administrativos, directivos, funcionarios y hasta egresados. Metodología: Estudio de caso que parte de un análisis del protocolo universitario salmantino a través de pares, de una reflexión posterior y su adaptación cultural al redactar el manual que contempla tanto la división de los actos, su naturaleza y su ejecución presencial o en línea. Resultados: La generación de un manual y la implementación de una estrategia de comunicación para su socialización, conocimiento y uso nos ha permitido cuidar la imagen de nuestros actos, consiguiendo a través de su organización, aquello que deseamos comunicar desde la excelencia. Discusión: En la fase de ejecución, contar un protocolo bien definido con criterios y estrategias ha permitido establecer el orden y la forma de comunicación, tanto para quienes los organizan como para quienes participan de ellos. Se logra un mejor desempeño respecto a los que no cuentan con ello. Conclusiones: El protocolo y el ceremonial, al establecer correctamente las precedencias de autoridades y al conocer y acercar las herramientas necesarias para la organización de cualquier acto, permiten comunicar la identidad UPAEP tanto interna como externamente.