bluuebunny/crossref_metadata_2025_split huggingface dataset:
6 Free will and criminal responsibility
Authors: Deeley Quinton 
Published: December 2022

Dr Deeley MA, MRCPsych, PhD, is an honorary consultant psychiatrist in the National Autism Unit, Adult ADHD Service, and Behavioural Genetics and Autism Assessment Clinic. He is also senior lecturer in social behaviour and neurodevelopment at the Institute of Psychiatry, Kings College London. He is approved under section 12 (2) of the 1983 Mental Health Act. Dr Deeley has wide experience of general adult and developmental psychiatry, having worked with patients across a range of settings, including secure hospital care, ‘step down’ open rehabilitation wards, supported living, and outpatient services. Dr Deeley specialises in the assessment and management of autistic spectrum disorders, attention deficit hyperactivity disorder, learning disability, and common mental health conditions. Dr Deeley holds a BA in Theology and Religious Studies from the University of Cambridge. He went on to complete medical training at Guys and St Thomas’ Hospitals before training in psychiatry on the Maudsley Hospital training scheme. He has a PhD in the cognitive neuroscience of autism and psychopathy. He is a member of the Royal College of Psychiatrists.AbstractNotions of criminal responsibility presuppose that a person can be held morally and legally accountable for acts which are freely chosen. Philosophical accounts of free will – of intended actions under individual control – provide a framework for analysing the components of freely chosen actions. Philosophers have explored the notion of free will in light of causal determinism, examining whether or how a person ‘could have done otherwise’ in specific circumstances such that they can be considered truly responsible for their actions. In this talk we consider these philosophical analyses and their relevance for neuropsychiatric assessment of offenders. In so doing we will also explore how evolving neuropsychiatric insights into the control of behaviour, and its impairment in specific disorders, has implications both for philosophical accounts of free will and notions of criminal responsibility.
Electronic nicotine delivery systems (ENDS) flavours and devices used by adults before and after the 2020 US FDA ENDS enforcement priority: findings from the 2018 and 2020 US ITC Smoking and Vaping Surveys
Authors: Gravely Shannon , Meng Gang , Hammond David , Reid Jessica L , Seo Young S , Hyland Andrew , Cummings K Michael , Rivard Cheryl , Fong Geoffrey T , Kasza Karin A 
Published: December 2022

BackgroundIn February 2020, the US Food and Drug Administration (FDA) prioritised enforcement efforts against flavoured prefilled cartridge/pod electronic nicotine delivery systems (ENDS), with the exception of tobacco and menthol. This study examined changes between prepriority enforcement (2018) and early postenforcement (February–June 2020) among adults on: ENDS flavours and devices used most often; location of last purchase of fruit/other-flavoured cartridges (covered under the enforcement priority); and smoking and vaping.MethodsPrevalence estimates came from 1608 adult frequent (≥weekly) ENDS users (current smokers (n=1072), ex-smokers (n=536)) who participated in the 2018 and/or 2020 US ITC Smoking and Vaping Surveys. Transitions between flavours/devices and changes in smoking/vaping were assessed among baseline respondents who were followed up in 2020 (n=360). Respondents self-reported the ENDS device (disposable, cartridge/pod or tank) and the flavor that they used most often: (1) tobacco flavors (tobacco/tobacco-menthol mix) or unflavored; (2) menthol/mint; (3) fruit/other flavors.ResultsCompared to 2018, in the first 5 months of the 2020 enforcement priority, there were significant increases in the prevalence of fruit/other-flavoured cartridges (7.9% to 12.4%,p=0.026) and menthol/mint cartridges (7.1% to 13.0%, p<0.01) and decreases in tobacco-flavoured tanks (15.5% to 10.0%,p=0.002) and fruit/other-flavoured tanks (38.7% to 33.6%,p=0.038). Fewer than 10% of adults used disposables in 2018 and 2020. Among the cohort sample, the most pronounced transitions between flavours/devices occurred among those who used flavoured cartridges covered under the enforcement priority (54.6% switched to a flavour and/or device excluded from enforcement). There was an increase in purchasing fruit/other-flavoured cartridges online and a decrease in retail locations except for vape shops. Overall, there were few changes in smoking and vaping behaviours.ConclusionsBetween 2018 and the early phase of the FDA’s 2020 enforcement priority, prevalence of menthol/mint and fruit/other-flavoured cartridges increased among adults. Half of vapers using cartridge flavours covered in the enforcement switched to other flavours and/or devices that were exempt, with the exception of disposables. The extent to which more comprehensive restrictions may be problematic for adults who prefer a range of ENDS flavours remains uncertain.
E-cigarette and tobacco product use among NYS youth before and after a state-wide vaping flavour restriction policy, 2020–2021
Authors: Schneller Liane M , Kasza Karin A , Hammond David , Bansal-Travers Maansi , O'Connor Richard , Hyland Andrew 
Published: December 2022

SignificanceReducing youth e-cigarette use is a New York State (NYS) public health priority. In May 2020, a state-wide restriction on flavoured e-cigarettes, except tobacco flavour, was passed. This study examines changes in nicotine product use behaviour among youth around the time of the state-wide vaping flavour restriction.MethodsNYS data from the US International Tobacco Control Policy Evaluation Project Youth Tobacco and E-cigarette Tobacco and Vaping Survey were analysed cross-sectionally from February 2020 (n=955), August 2020 (n=946), February 2021 (n=1030) and August 2021 (n=753). Online surveys were conducted among youth 16–19 years. Weighted descriptive statistics and regression models were used to describe changes in nicotine product use behaviour. Models were adjusted for age, sex, race/ethnicity and perceived family socioeconomic status.ResultsSignificant decreases in past 30-day e-cigarette use (20%–11%), cigarette (7%-4%), and dual use of e-cigarettes and cigarettes (5%–2%) were observed over the 2-year period in NYS. Over 95% of vapers still reported using a non-tobacco-flavoured e-cigarette following the restriction, with fruit-flavoured being the most popular at each time point.ConclusionsNearly all NYS youth continued to vape flavours that were restricted in NYS. While youth past 30-day vaping prevalence decreased significantly from 2020 to 2021, increased flavour restriction compliance could result in an even greater decrease. Continuous monitoring is important to better understand perceptions, use patterns and access at the individual level, retail level and population level to inform future enforcement and restrictions.
On isospin and flavour of leptons and quarks
Authors: Marsch Eckart , Narita Yasuhito 
Published: December 2022

AbstractIsospin emerges naturally from the Lorentz transformation of spinors, if they are based on the vector representation of the Lorentz group. The resulting extended Dirac equation for a massive spin-one-half fermion has two new additional degrees of freedom associated with the up and down components of isospin. This doublet is interpreted as describing the electron and neutrino. It is adjoined with the SU(2) symmetry group. The extended Dirac equation appears in six versions which are connected by similarity transformations. It is argued that this trait may explain the occurrence of the three families of the leptons and suggested that flavour arises genuinely from the algebraic properties of the extended Dirac equation. Its solutions are discussed and the physical role of isospin is elucidated. Isospin symmetry can be gauged, which leads to a weak-interaction-type theory and is valid for finite initial mass. Breaking the isospin SU(2) symmetry yields the correct electric charges of the particles by means of the electroweak unification procedures of the standard model.
A Coordination Mechanism for Scheduling Game on Parallel-Batch Machines with Deterioration Jobs
Authors: Yu Ganhua 
Published: December 2022

In this study, we consider a parallel-batch machines scheduling game problem with deterioration jobs. The processing time of a job is a simple linear function of its starting time. Each of the parallel-batch machines can process up to

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jobs simultaneously as a batch. The processing time of a batch is the processing time of the job with the longest deteriorating rate in the batch. All jobs in the same batch start and complete at the same time. Each job as an agent and its individual cost is the completion time of the job. We present a coordination mechanism for the scheduling game problem with social cost of minimizing the makespan in this paper, namely fully batch longest deteriorating rate. For this problem, we precisely quantify the inefficiency of Nash equilibrium by the logarithm price of anarchy. It is defined to be the ratio between the logarithm of social cost of the worst Nash equilibrium and the logarithm of social cost of an optimum schedule. In addition, we discuss the existence of Nash equilibrium and present an upper bound and lower bounds on the logarithm price of anarchy of the coordination mechanism. We show that the mechanism has a logarithm price of anarchy at most

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Effect of Intensive Blood Pressure Control on Troponin and Natriuretic Peptide Levels: Findings From SPRINT
Authors: Berry Jarett D. , Chen Haiying , Nambi Vijay , Ambrosius Walter T. , Ascher Simon B. , Shlipak Michael G. , Ix Joachim H. , Gupta Rajesh , Killeen Anthony , Toto Robert D. , Kitzman Dalane W. , Ballantyne Christie M. , de Lemos James A. 
Published: December 2022

Background:
Given the important role of cardiac injury and neurohormonal activation in the pathways leading from hypertension to heart failure and strong associations observed between hypertension and its sequelae on hs-cTnT (high-sensitivity cardiac troponin T) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels, we hypothesized that intensive systolic blood pressure (SBP) lowering would decrease levels of hs-cTnT and NT-proBNP.

Methods:
hs-cTnT and NT-proBNP were measured at baseline and 1 year from stored specimens in SPRINT (Systolic Blood Pressure Intervention Trial). Changes in biomarkers were evaluated continuously on the log scale and according to categories (≥50% increase, ≥50% decrease, or <50% change). The effect of intensive SBP lowering on continuous and categorical changes in biomarker levels were assessed using linear and multinomial logistic regression models, respectively. The association between changes in biomarkers on heart failure and death was assessed using multivariable-adjusted Cox proportional hazards models.

Results:
Randomization to intensive SBP lowering (versus standard SBP management) resulted in a 3% increase in hs-cTnT levels over 1-year follow-up (geometric mean ratio, 1.03 [95% CI, 1.01–1.04]) and a higher proportion of participants with ≥50% increase (odds ratio, 1.47 [95% CI, 1.13, 1.90]). In contrast, randomization to intensive SBP lowering led to a 10% decrease in NT-proBNP (geometric mean ratio, 0.90 [95% CI, 0.87–0.93]) and a lower probability of ≥50% increase in NT-proBNP (odds ratio, 0.57 [95% CI, 0.46–0.72]). The association of randomized treatment assignment on change in hs-cTnT was completely attenuated after accounting for changes in estimated glomerular filtration rate over follow-up, whereas the association of treatment with NT-proBNP was completely attenuated after adjusting for change in SBP. Increases in hs-cTnT and NT-proBNP from baseline to 1 year were associated with higher risk for heart failure and death, with no significant interactions by treatment assignment.

Conclusions:
Intensive SBP lowering increased hs-cTnT, mediated by the effect of SBP lowering on reduced kidney filtration. In contrast, intensive SBP lowering decreased NT-proBNP, a finding that was explained by the decrease in SBP. These findings highlight the importance of noncardiac factors influencing variation in cardiac biomarkers and raise questions about the potential role of hs-cTnT as a surrogate marker for heart failure or death in SBP-lowering studies.
Service use preceding and following first referral for psychiatric emergency care at a short-stay crisis unit: A cohort study across three cities and one rural area in England
Authors: Goldsmith Lucy Pollyanna , Anderson Katie , Clarke Geraldine , Crowe Chloe , Jarman Heather , Johnson Sonia , Lomani Jo , McDaid David , Park A-La , Smith Jared G , Gillard Steven 
Published: December 2022

Background: Internationally, hospital-based short-stay crisis units have been introduced to provide a safe space for stabilisation and further assessment for those in psychiatric crisis. The units typically aim to reduce inpatient admissions and psychiatric presentations to emergency departments. Aims: To assess changes to service use following a service user’s first visit to a unit, characterise the population accessing these units and examine equality of access to the units. Methods: A prospective cohort study design (ISCTRN registered; 53431343) compared service use for the 9 months preceding and following a first visit to a short-stay crisis unit at three cities and one rural area in England. Included individuals first visited a unit in the 6 months between 01/September/2020 and 28/February/2021. Results: The prospective cohort included 1189 individuals aged 36 years on average, significantly younger (by 5–13 years) than the population of local service users (<.001). Seventy percent were White British and most were without a psychiatric diagnosis (55%–82% across sites). The emergency department provided the largest single source of referrals to the unit (42%), followed by the Crisis and Home Treatment Team (20%). The use of most mental health services, including all types of admission and community mental health services was increased post discharge. Social-distancing measures due to the COVID-19 pandemic were in place for slightly over 50% of the follow-up period. Comparison to a pre-COVID cohort of 934 individuals suggested that the pandemic had no effect on the majority of service use variables. Conclusions: Short-stay crisis units are typically accessed by a young population, including those who previously were unknown to mental health services, who proceed to access a broader range of mental health services following discharge.
Antibiotic prophylaxis prior to transrectal prostate biopsy in Croatia: A national survey
Authors: Neretljak Ivan , Jurinčić Mario , Smojver Hrvoje , Jurenec Franjo , Vuković Jurica , Orešković Janko , Šanjek-Muren Tvrtko , Sučić Mario 
Published: December 2022

Objectives: Transrectal ultrasound guided prostate biopsy (TRUSPB) is the standard of care for diagnosis of prostate cancer. Increased antibiotic resistance has led to the suspension of indication for fluoroquinolones use in prostate biopsy prophylaxis. Several classes of antibiotics have been recommended for routine use. Unequivocal consensus regarding antibiotic prophylaxis has not been made to date. The objective of the study was to assess the diversity of antimicrobial prophylaxis among Croatian urologists. Materials and methods: An online questionnaire was designed using Google Forms® and distributed to 19 urology public hospital’s departments. Answers regarding infection risk assessment, type and duration of antimicrobial prophylaxis were accumulated. Descriptive statistical analysis was preformed using Statistica 10.0® analytics software. Results: Twelve urology departments answered the questionnaire, representing 63% of urology departments in Croatia. Six different antibiotic protocols have been reported. Fluoroquinolones were the most commonly prescribed class of antibiotics (84%). Antibiotic prophylaxis started 1 day before the procedure (92%). Average duration of antibiotic prophylaxis was 5 days (75%). In case of increased risk of urinary tract infection, 42% of departments changed the type, and 8% changed the duration of antibiotic prophylaxis. Neither department performed a rectal swab prior to prostate biopsy. Conclusions: Various antimicrobial prophylaxis protocols are currently being used among Croatian urology departments. Lack of uniform guidelines contributes to protocol diverseness that inevitably leads to further increase in antibiotic resistance. New high quality studies are needed to reverse this trend and to facilitate the establishment of a uniform antimicrobial stewardship strategy.
Enriching single-arm clinical trials with external controls: possibilities and pitfalls
Authors: Lambert Jérôme , Lengliné Etienne , Porcher Raphaël , Thiébaut Rodolphe , Zohar Sarah , Chevret Sylvie 
Published: December 2022

Abstract
For the past decade, it has become commonplace to provide rapid answers and early patient access to innovative treatments in the absence of randomized clinical trials (RCT), with benefits estimated from single-arm trials. This trend is important in oncology, notably when assessing new targeted therapies. Some of those uncontrolled trials further include an external/synthetic control group as an innovative way to provide an indirect comparison with a pertinent control group. We aimed to provide some guidelines as a comprehensive tool for (1) the critical appraisal of those comparisons or (2) for performing a single-arm trial. We used the example of ciltacabtagene autoleucel for the treatment of adult patients with relapsed or refractory multiple myeloma after 3 or more treatment lines as an illustrative example. We propose a 3-step guidance. The first step includes the definition of an estimand, which encompasses the treatment effect and the targeted population (whole population or restricted to single-arm trial or external controls), reflecting a clinical question. The second step relies on the adequate selection of external controls from previous RCTs or real-world data from patient cohorts, registries, or electronic patient files. The third step consists of choosing the statistical approach targeting the treatment effect defined above and depends on the available data (individual-level data or aggregated external data). The validity of the treatment effect derived from indirect comparisons heavily depends on careful methodological considerations included in the proposed 3-step procedure. Because the level of evidence of a well-conducted RCT cannot be guaranteed, the evaluation is more important than in standard settings.
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Authors: Jia Yan , Zhao Jianing , Yu Tao , Zhang Xue , Qi Xiaozhen , Hao Tongxin , Jin Zeyuan , Zhao Xiaoqing 
Published: December 2022

Abstract
Background
Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key component of RNA interference (RNAi) pathway. Here we performed a yeast two-hybrid screen using the human Argonaute 2 PIWI domain as bait to screen for new AGO2-interacting proteins and explored the specific mechanism through a series of molecular biology and biochemistry experiments.

Methods
The yeast two-hybrid system was used to screen for AGO2-interacting proteins. Co-immunoprecipitation and immunofluorescence assays were used to further determine interactions and co-localization. Truncated plasmids were constructed to clarify the interaction domain. EGFP fluorescence assay was performed to determine the effect of PSMC3 on RNAi. Regulation of AGO2 protein expression and ubiquitination by PSMC3 and USP14 was examined by western blotting. RT-qPCR assays were applied to assess the level of AGO2 mRNA. Rescue assays were also performed.

Results
We identified PSMC3 (proteasome 26S subunit, ATPase, 3) as a novel AGO2 binding partner. Biochemical and bioinformatic analysis demonstrates that this interaction is performed in an RNA-independent manner and the N-terminal coiled-coil motif of PSMC3 is required. Depletion of PSMC3 impairs the activity of the targeted cleavage mediated by small RNAs. Further studies showed that depletion of PSMC3 decreased AGO2 protein amount, whereas PSMC3 overexpression increased the expression of AGO2 at a post-translational level. Cycloheximide treatment indicated that PSMC3 depletion resulted in a decrease in cytoplasmic AGO2 amount due to an increase in AGO2 protein turnover. The absence of PSMC3 promoted ubiquitination of AGO2, resulting in its degradation by the 26S proteasome. Mechanistically, PSMC3 assists in the interaction of AGO2 with the deubiquitylase USP14(ubiquitin specific peptidase 14) and facilitates USP14-mediated deubiquitination of AGO2. As a result, AGO2 is stabilized, which then promotes RNAi.

Conclusion
Our findings demonstrate that PSMC3 plays an essential role in regulating the stability of AGO2 and thus in maintaining effective RNAi.
Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion
Authors: Sun Xiaohe , Jin Jiamin , Zhang Yin-Li , Ma Yerong , Zhang Songying , Tong Xiaomei 
Published: December 2022

Abstract
Background
Recurrent spontaneous abortion (RSA) is a common and complicated pregnancy-related disease that lacks a suitable biomarker to predict its recrudescence.

Methods
Tandem mass tag (TMT) analysis was conducted to obtain quantitative proteomic profiles in follicular fluid from patients with a history of RSA and from control group. ELISA validation of candidate differentially expressed proteins was conducted in a larger group of patients.

Results
A total of 836 proteins were identified by TMT analysis; 51 were upregulated and 47 were downregulated in follicular fluid from cases of RSA versus control group. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis revealed several important pathways were enriched, involving a dysregulated immunoglobulin Fc receptor signaling pathway and overactivated complement cascade pathways. ELISA validated the differential expression of two proteins, histidine-rich globulin (HRG) and complement C4-B (C4B), which were downregulated and upregulated, respectively, in follicular fluid of patients with RSA. We performed receiver operating characteristic curve analysis of the ELISA results with the outcomes of current IVF cycles as classification variables. The area under the curve results for HRG alone, C4B alone and HRG-C4B combined were 0.785, 0.710 and 0.895, respectively.

Conclusions
TMT analysis identified 98 differentially expressed proteins in follicular fluid from patients with RSA, indicating follicle factors that act as early warning factors for the occurrence of RSA. Among them, HRG and C4B provide candidate markers to predict the clinical outcomes of IVF/ICSI cycles, and the potential for modeling an early detection system for RSA.