bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wound healing activity of Salvia huberi ethanolic extract in streptozocin-induced diabetic rats
Authors: Ozay Yusuf , Ozkorkmaz Ebru Gokalp , Kumas-Kulualp Meltem , Kara Sevda Guzel , Yildirim Zuhal , Uzun Cosar , Celik Ayla , Camlica Yusuf , Bozgeyik Ibrahim , Guler Gizem , Erdal Nurten , Yumrutas Onder , Tasdelen Bahar , Kahraman Ahmet 
Published: March 2023

Objective: The aim of this study was to examine the in vivo wound healing potential of Salvia huberi Hedge (endemic to Turkey) on excision and incision wound models in diabetic rats. Method: Male Wistar albino rats, 3-4 months old and weighing 180-240g were used. The animals were randomly divided into five groups including Control, Vehicle and Fito reference, and two different concentrations (0.5% and 1% weight/weight (w/w)) of ethanol extract of Salvia huberi were investigated in both wound models on streptozocin-induced diabetic rats using macroscopic, biomechanical, biochemical, histopathological, genotoxic and gene expression methods over both seven and 14 days. Fito cream (Tripharma Drug Industry and Trade Inc., Turkey) was used as the reference drug. Results: A total of 60 rats were used in this study. Salvia huberi ointments at 0.5% and 1% (w/w) concentrations and Fito cream showed 99.3%, 99.4% and 99.1% contraction for excision wounds, and 99.9%, 97.0% and 99% contraction for incision wounds, respectively. In Salvia huberi ointments and Fito cream groups, re-epithelialisation increased dramatically by both day 7 and day 14 (p<0.05). By day 14, low hydroxyproline and malondialdehyde (MDA) levels, and high glutathione (GSH) levels were observed in the Salvia huberi ointment groups. After two application periods, damaged cell percent and genetic damage index values and micronucleus frequency of Salvia huberi ointment treatment groups were lower than Control and Vehicle groups (p<0.001). A growth factor expression reached a high level by day 7 in the Control group; in Salvia huberi-treated groups it was decreased. Conclusion: The study showed that application of Salvia huberi ointments ameliorated the healing process in diabetic rats with excisional and incisional wounds and may serve as a potent healing agent.
Topical formulation containing chitosan-chamomile microparticles in cutaneous wound healing in rats
Authors: Garbuio Danielle Cristina , Leite Marcel Nani , Figueiredo Sonia Aparecida , de Freitas Luís Alexandre Pedro , de Carvalho Emília Campos , Frade Marco Andrey Cipriani 
Published: March 2023

Objective: The aim of this research was to evaluate the efficacy of a topical formulation containing chitosan-chamomile microparticles in cutaneous healing in rats. Method: Male Wistar rats (n=57) were randomly distributed into three groups: treatment; vehicle; and control. Evaluations were performed on days 2, 7 and 14 after the surgical procedure using skin lesion photography, and histological and biochemical analyses. Results: The results showed that there was no difference in the healing index and in the histological analysis of the inflammatory infiltrate among groups. Fibrogenesis was more significant in the group treated with the test formulation at day 7, and angiogenesis was greater in the vehicle and chamomile groups at day 2. The quantification of hydroxyproline showed a higher amount of collagen in the group treated with chamomile, mainly at day 14, although the histological quantification of collagen showed no difference between the groups. Conclusion: From the results of this study, it can be concluded that the formulation, although it had no effect on the healing time, improved the quality of the cicatricial tissue formed with a greater quantity of fibroblasts and collagen.
Effect of four-layer dressing on the microbiological profile of venous leg ulcer
Authors: Tiwary Satyendra K , Choubey Katyayani K , Nath Gopal , Kumar Puneet , Khanna Ajay K 
Published: March 2023

Objective: Venous leg ulcer (VLU) is a chronic disease and has periods of exacerbation and remission. Various bandage systems—single-layered, double-layered and multiple-layered with elastic and non-elastic components—have been developed. The requirement for sustained pressure brought about the introduction of the four-layer bandage. We studied the bacteriology of VLUs and the effect of four-layer bandages on their healing. Method: Clinical details of all patients, with wound size measurement by gauze piece, wax paper and scale, were recorded. The wounds were initially debrided and photographic records of all patients were maintained. Patients were followed up every week, when the dressings and four-layer bandages were changed. Results: A total of 60 patients were recruited to the study with four patients having bilateral disease and so a total of 64 VLUs were evaluated. Of these, 60 (93.8%) healed completely, one (1.6%) healed partially and three (4.7%) did not heal. After excluding the four VLUs that did not fully heal, 10 (16.7%) had recurrence while 50 (83.3%) had no recurrence in the follow-up period, which lasted for one year. During the first visit (baseline), meticillin-resistant Staphylococcus aureus (MRSA) was isolated in 29 (45.31%) VLUs and Pseudomonas spp. in 20 (31.25%) VLUs. With subsequent dressing, the VLU size decreased and the culture of the VLU was sterile from the third culture onwards in 45 cases. There was a significant correlation (p<0.001) between VLU size and the number of dressings. Conclusion: Compression therapy is the mainstay of treatment of VLU, with rapid healing and improvement in bacteriological profile. Compression in the range of 30–40mmHg is the most effective treatment for uncomplicated VLUs with adequate arterial competency.
Characteristics of COVID-19 patients who developed pressure injuries: a scoping review
Authors: Sandhu Julie , Miller Charne , Kapp Suzanne 
Published: March 2023

Objective: To describe the characteristics of patients with COVID-19 who developed pressure injuries (PIs), the characteristics of PIs experienced, and the incidence and prevalence of PIs among the patients with COVID-19. PIs are associated with increased morbidity, mortality and healthcare expense. PIs have been reported among patients who have contracted COVID-19. Understanding the characteristics of COVID-19 patients, and how PIs are prevented and managed, may inform care and optimise the outcomes for COVID-19-positive patients. Method: A scoping review was conducted. All study designs, including grey literature, published in the English language from December 2019 to March 2021, reporting on patients with COVID-19 and PIs, were included. Results: In total, 27 publications (n=4820 patients) were included in the review. The reported incidence rate of PIs was 7.3–77.0%. The causative factors noted were: prone positioning (28.5%); medical devices (21.4%); and medical devices used during prone positioning (14.2%). The most common PI sites were the cheeks (18.7%). PIs occurred on average at 14.7 days post-acute care admission. Of the PIs where staging information was specified (67.7%), the most common was Stage 2/II (45.2%). PI risk may intensify on account of the intrinsic mechanism of COVID-19-associated intensive care treatment. Conclusion: PI prevention and management should be prioritised for patients with COVID-19, given the reported high prevalence of PIs and exacerbated risk arising from the use of prone position and medical devices. Further research is required to understand the association between COVID-19 and PIs, and to guide effective prevention and treatment approaches.
Clinical courses, impact and prognostic indicators for a persistent course of low back pain: Results from a population-based cohort study
Authors: Gomes Luís Antunes , Rodrigues Ana Maria , Branco Jaime C. , Canhão Helena , Cruz Eduardo Brazete 
Published: March 2023

Background
Low back pain (LBP) is a long-term health condition with distinct clinical courses. Its characterization together with the identification of prognostic factors for a persistent LBP course may trigger the development of personalized interventions. This study aimed to investigate the courses of chronic LBP (CLBP), its cumulative impact, and the indicators for the persistence of pain.

Material and methods
Patients with active CLBP from the EpiDoC, a population-based cohort study of a randomly recruited sample of 10.661 adults with prolonged follow-up, were considered. Pain, disability, and health-related quality of life (HRQoL) were assessed at three time-points over five years. According to their pain symptoms over time, participants were classified as having a persistent (pain at the baseline and at all the subsequent time-points) or a relapsing pain course (pain at the baseline and no pain at least in one of the subsequent time-points). A mixed ANOVA was used to compare mean differences within and between patients of distinct courses. Prognostic indicators for the persistent LBP course were modulated through logistic regression.

Results
Among the 1.201 adults with active CLBP at baseline, 634 (52.8%) completed the three time-points of data collection: 400 (63.1%) had a persistent and 234 (36.9%) a relapsing course. Statistically significant interactions were found between the group and time on disability (F (2,1258) = 23.779, p<0.001) and HRQoL (F (2,1252) = 82.779, p<0.001). In the adjusted model, the persistent course was associated with the disability level (OR 1.86, CI95% 1.40–2.40, p<0.001), depressive symptoms (OR 1.96, CI95% 1.21–3.18, p = 0.007), female gender (OR 1.90, CI95% 1.26–2.87, p = 0.002) and having a manual job (OR 1.46, CI95% 1.02–2.10, p = 0.040).

Conclusion
In the long-term, patients with CLBP may follow a persistent or relapsing course of pain. Being female, presenting depressive symptoms, having a manual job and higher disability at baseline predicts a persistent course of LBP.
The effects of simple graphical and mental visualization of lung sounds in teaching lung auscultation during clinical clerkship: A preliminary study
Authors: Kuriyama Ayaka , Kasai Hajime , Shikino Kiyoshi , Shiko Yuki , Kawame Chiaki , Takeda Kenichiro , Tajima Hiroshi , Hayama Nami , Suzuki Takuji , Ito Shoichi 
Published: March 2023

IntroductionThe study aimed to evaluate visualization-based training’s effects on lung auscultation during clinical clerkship (CC) in the Department of Respiratory Medicine on student skills and confidence.MethodsThe study period was December 2020–November 2021. Overall, 65 students attended a lecture on lung auscultation featuring a simulator (Mr. Lung™). Among them, 35 (visualization group) received additional training wherein they were asked to mentally visualize lung sounds using a graphical visualized lung sounds diagram as an example. All students answered questions on their self-efficacy regarding lung auscultation before and after four weeks of CC. They also took a lung auscultation test with the simulator at the beginning of CC (pre-test) and on the last day of the third week (post-test) (maximum score: 25). We compared the answers in the questionnaire and the test scores between the visualization group and students who only attended the lecture (control group, n = 30). The Wilcoxon signed-rank test and analysis of covariance were used to compare the answers to the questionnaire about confidence in lung auscultation and the scores of the lung auscultation tests before and after the training.ResultsConfidence in auscultation of lung sounds significantly increased in both groups (five-point Likert scale, visualization group: pre-questionnaire median 1 [Interquartile range 1] to post-questionnaire 3 [1],p<0.001; control group: 2 [1] to 3 [1],p<0.001) and was significantly higher in the visualization than in the control group. Test scores increased in both groups (visualization group: pre-test 11 [2] to post-test 15 [4],p<0.001; control group: 11 [5] to 14 [4],p<0.001). However, there were no differences between both groups’ pre and post-tests scores (p= 0.623).ConclusionVisualizing lung sounds may increase medical students’ confidence in their lung auscultation skills; this may reduce their resistance to lung auscultation and encourage the repeated auscultation necessary to further improve their long-term auscultation abilities.
Concerted and multidisciplinary management of COVID-19 drug therapies during the first two epidemic waves in a tertiary hospital in Marseille, France: Results of the PHARMA-COVID study
Authors: Peretti Matthieu , Rebaudet Stanislas , Chiche Laurent , Pegliasco Hervé , Coquet Emilie 
Published: March 2023

Objectives
To evaluate the impact of local therapeutic recommendation updates made by the COVID multidisciplinary consultation meeting (RCP) at the Hôpital Européen Marseille (HEM) through the description of the drug prescriptions for COVID-19 during the first two waves of the epidemic.

Methods
This retrospective observational study analysed data from the hospital’s pharmaceutical file. We included all patients hospitalized for COVID-19 between February 1, 2020 and January 21, 2021 and extracted specific anti-COVID-19 therapies (ST) from computerized patient record, as well as patients’ demographic characteristics, comorbidities and outcome. The evolution of ST prescriptions during the study period was described and put into perspective with the updates of local recommendations made during the first (V1, from 2/24/2020 to 7/27/2020), and second (V2, from 7/28/2020 to 1/21/2021) epidemic waves.

Results
A total of 607 COVID-19 hospitalized patients, 197 during V1 and 410 during V2. Their mean age was 65 years-old, and they presented frequent comorbidities. In total, 93% of hospitalized patients received ST: anticoagulants (90%), glucocorticoids (39%) mainly during V2 (49% vs 17%, P<0.001), and azithromycin (30%) mainly during V1 (71% vs 10%, P<0.001). Lopinavir/ritonavir and hydroxychloroquine were prescribed to 17 and 7 inpatients, respectively, and only during V1. Remdesivir was never administered. A total of 22 inpatients were enrolled into clinical trials.

Conclusions
The effective dissemination of evidence-based and concerted recommendations seems to have allowed an optimized management of COVID-19 drug therapies in the context of this emerging infection with rapidly evolving therapeutic questions.
Factors associated with prevalent Mycobacterium tuberculosis infection and disease among adolescents and adults exposed to rifampin-resistant tuberculosis in the household
Authors: Kim Soyeon , Hesseling Anneke C. , Wu Xingye , Hughes Michael D. , Shah N. Sarita , Gaikwad Sanjay , Kumarasamy Nishi , Mitchell Erika , Leon Mey , Gonzales Pedro , Badal-Faesen Sharlaa , Lourens Madeleine , Nerette Sandy , Shenje Justin , de Koker Petra , Nedsuwan Supalert , Mohapi Lerato , Chakalisa Unoda A. , Mngqbisa Rosie , Escada Rodrigo Otávio da Silva , Ouma Samuel , Heckman Barbara , Naini Linda , Gupta Amita , Swindells Susan , Churchyard Gavin ,   on behalf of the ACTG A5300/IMPAACT 2003 PHOENIx Feasibility Study Team
Published: March 2023

Background
Understanding factors associated with prevalent Mycobacterium tuberculosis infection and prevalent TB disease in household contacts of patients with drug-resistant tuberculosis (TB) may be useful for TB program staff conducting contact investigations.

Methods
Using data from a cross-sectional study that enrolled index participants with rifampin-resistant pulmonary TB and their household contacts (HHCs), we evaluated HHCs age ≥15 years for factors associated with two outcomes: Mycobacterium tuberculosis infection and TB disease. Among HHCs who were not already diagnosed with current active TB disease by the TB program, Mycobacterium tuberculosis infection was determined by interferon-gamma release assay (IGRA). TB disease was adjudicated centrally. We fitted logistic regression models using generalized estimating equations.

Results
Seven hundred twelve HHCs age ≥15 years enrolled from 279 households in eight high-TB burden countries were a median age of 34 years, 63% female, 22% current smokers and 8% previous smokers, 8% HIV-positive, and 11% previously treated for TB. Of 686 with determinate IGRA results, 471 tested IGRA positive (prevalence 68.8% (95% Confidence Interval: 64.6%, 72.8%)). Multivariable modeling showed IGRA positivity was more common in HHCs aged 25–49 years; reporting prior TB treatment; reporting incarceration, substance use, and/or a period of daily alcohol use in the past 12 months; sharing a sleeping room or more evenings spent with the index participant; living with smokers; or living in a home of materials typical of low socioeconomic status.
Forty-six (6.5% (95% Confidence Interval: 4.6%, 9.0%)) HHCs age ≥15 years had prevalent TB disease. Multivariable modeling showed higher prevalence of TB disease among HHCs aged ≥50 years; reporting current or previous smoking; reporting a period of daily alcohol use in the past 12 months; and reporting prior TB treatment.

Conclusion
We identified overlapping and distinct characteristics associated with Mycobacterium tuberculosis infection and TB disease that may be useful for those conducting household TB investigations.
Estimation of population structure, growth and condition of Parastromateus niger in the Bay of Bengal
Authors: Husna Asmaul , Mondol Md. Rashedul Kabir , Hasan Md Rabiul , Hossain Md. Yeamin 
Published: March 2023

Black pomfret (Parastromateus niger) is one of the major commercial species of pomfret fishery in Bangladesh. This study illustrates the population structure (Length Frequency Distribution, LFD), relationship between length and weight (LWR), relationships between length and length (LLRs), Fulton’s condition factor (KF) and relative weight (WR) of P. niger in the Bay of Bengal (BoB). A total of 225 P. niger were collected from the four locations during January to December 2020. LFD analysis indicates three length classes 21-27 cm, 30-32 cm and 35-37 cm, respectively. This species showed isometric growth pattern (b = 2.981) that indicates that the size and weight increases proportionally and the surrounding habitat provides favourable environment for the growth. LWR between TL and BW were highly correlated (r² = 0.951). LLRs also showed significant correlation between TL and SL (r² = 0.845) and TL and FL (r² = 0.861). The mean value of KF was found as 1.60 which indicates that the BoB provides healthy environment for this species. The mean value of WR (101.09) indicates that the relationship between prey and predator was in balanced condition. This study suggests optimum catchable length for P. niger at 27 cm. Therefore, these findings could provide important information to design effective conservation and management planning for this species.
Authenticating the administrative contract in electronic form and its legal force in Jordanian law
Authors: AlOmran Nayel , Al-Qassaymeh Maen 
Published: March 2023

The administrative contract is one of the transactions that may be concluded electronically. For this reason, it is important that it is legally regulated. The electronic contract is created by special procedures via electronic certification bodies. This article considers the authentication of the electronic administrative contract in Jordan. It also examines the legal value of the contract before the Jordanian judiciary.
Index words: Jordan; Electronic Transactions Law No 15 of 2015; Jordanian Evidence Law; electronic administrative contract; electronic journals; electronic signature; electronic certification
Universitätsbibliotheken im Jahre 2040
Authors: Mumenthaler Rudolf 
Published: March 2023

Zusammenfassung
Im Beitrag wird die Vision einer Universitätsbibliothek im Jahre 2040 entworfen. Die Aufgaben und Rollen von Bibliotheken in einer Gesellschaft, die zum einen stark digitalisiert unterwegs ist, zum anderen aber auch einen großen Bedarf an sozialen Kontakten hat, werden skizziert. Die Art, wie Medien und Information genutzt wird, hat sich radikal verändert. Kernstück ist eine Informationsplattform, auf der aufbereitete Inhalte mittels KI bedarfsgerecht bereitgestellt werden – von verlinkten Datenwolken über durch KI generierte Abstracts bis hin zu den zugrunde liegenden Daten. Durch die Rationalisierung der menschlichen Arbeit erhalten sinnvolle Freizeitbeschäftigungen und ständige Weiterbildung eine hohe Bedeutung – und die Bibliotheken spielen dabei eine wichtige Rolle.
The effects of heating rate and sintering time on the biaxial flexural strength of monolithic zirconia ceramics
Authors: Oyar Perihan , Durkan Rukiye 
Published: March 2023

Abstract
The strength of zirconia ceramic materials used in restorations is dependent upon sintering. Varying sintering protocols may affect the biaxial flexural strength of zirconia materials. This in vitro study was conducted to investigate the effects of sintering parameters on the biaxial flexural strength of monolithic zirconia. Two different monoblock zirconia ceramics were used. Following coloration, samples of both types of ceramics were divided into groups according to whether or not biaxial flexural strength testing was performed directly after sintering or following thermocycling. Biaxial flexural strength data was analysed with a Shapiro Wilk normality test, followed by 1-way ANOVA, Tukey post hoc tests for inter-group comparisons, and paired samples t-tests for intra-group comparisons. A significant difference was found between the biaxial flexural strengths of Zircon X and Upcera ceramics before thermocycling (p<0.05). In both Zircon X and Upcera ceramic groups, the thermocycling process created a significant difference in the biaxial flexural strength values of the ceramic samples in Group 6 (p<0.05) which had the slowest heating rate and longest holding time. The zirconia ceramics have higher BFS at higher heating rates either before or after thermocycling. The holding time has significant effects on thermocycling and flexural strength. The zirconia achieved its optimum strength when it sintered at longer time regardless of heating rates.
The Application of Emergency Management Principles to Violent Crime Response and Urban Resilience
Authors: Taylor David W. , Wood Erik , Frazier Tim 
Published: March 2023

Abstract
Violent crime is on the rise in many American cities and the annual cost to police and the community increases proportionally. Violent crime scenes are similar to the calamity experienced with natural or human-made disasters. Understanding how it could have been prevented, what services were needed, and what remaining gaps still exist in services and resources is critical. The narrative can be shifted by treating violent crime like naturally occurring disasters and applying comprehensive emergency management strategies to prepare, mitigate, respond, and recover from this whole community hazard. This dynamic emergency management-based approach outlines coordination across key agencies and stakeholders, and has the potential to mitigate the impact of violent crime in major urban cities in the United States (US). Using the District of Columbia (DC) as a sample study area, this policy proposal is supported by a qualitative analyses of available data, including from the limited existing literature and from related DC agencies. Findings demonstrate how the DC Homeland Security and Emergency Management Agency (DCHSEMA), can coordinate response and hold agencies accountable within its current capacity while supporting the interoperability of all related violent crime agencies involved. These findings have both national and international implications.