bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tandem Conversion of Fructose to Bio‐diketones Using a Multifunctional Pd‐POPs‐CF3SO3H Catalyst
Authors: Wang Guoqing , Jiang Miao , Sun Zhao , Qian Leilei , Ji Guangjun , Ma Lei , Li Cunyao , Du Hong , Yan Li , Ding Yunjie 
Published: August 2023

AbstractTandem conversion of biomass to value‐added fine chemicals is a significant challenge. For instance, the production of fine chemicals from fructose involves conversion to 5‐hydroxymethylfurfural (5‐HMF), followed by another reaction and purification. Dual catalyst systems have been used in nearly every study on the tandem conversion of fructose to bio‐diketones. Therefore, a sole multifunctional heterogeneous catalyst was developed in this study for the tandem conversion of fructose to bio‐diketones, which has not been reported previously. Instrument corrosion and the separation or purification of 5‐HMF were avoided using the multifunctional heterogeneous catalyst, which contained integrated active sites of acid, metal, and anions. The multifunctional CF3SO3H‐functionalized porous‐organic‐polymers(POPs)‐supported Pd catalyst (Pd‐POPs‐CF3SO3H) was prepared using a series of modifications. A bio‐diketone yield of 51.0 % was achieved using Pd‐POPs‐CF3SO3H in the tandem conversion of fructose with an excellent TOF of 88.3 h−1 which is much more efficient than catalyst reported in literatures. Pd‐POPs‐CF3SO3H could be reused at least three times with stable performance. Control experiments and characterization results proved that the high specific surface area, hierarchical pore structure, abundance of CF3SO3−1 anions, and proximity of Pd moieties and acid sites (“The closer the better” principle) led to the decent performance for bio‐diketone.
Synergistic Effect Enhancing Baeyer‐Villiger Oxidation Performance of Resin‐Derived‐Carbon Supported FeCe Bimetallic Catalyst
Authors: Liu Mengyang , Gu Bin , Li Jingmei , Wei Huangzhao , Xue Weiyang , Jiang Yukun , Sun Chenglin 
Published: August 2023

AbstractUpgrading cyclohexanone to ϵ‐caprolactone (ϵ‐CL) is of great importance to the synthesis of high value‐added downstream chemicals and the reduction of foam plastic. The catalytic synthesis of ϵ‐CL from cyclohexanone through O2/aldehyde method is an environmentally benign one‐pot tandem reaction without using peroxy acid, balancing the requirements of safety and efficiency. However, due to lack of elaborate design and collaboration of multiple active sites for catalysts, the catalytic efficiency of O2/aldehyde method still remains to be improved. Herein, a pitaya‐like catalyst (CeFe@RDC‐3) with Ce and Fe highly dispersed on resin‐derived‐carbon is synthesized through high temperature self‐assembly. On this bimetallic catalyst, high yield (97 %) of ϵ‐CL is achieved through aerobic oxidation of cyclohexanone with only 1.5 equivalent benzaldehyde. Moreover, considerable yields of ϵ‐CL, 88.3 % and 74.7 %, respectively, are also obtained over CeFe@RDC‐3 with green solvent (EtOAc) or even without solvent. No loss of activity is observed after five successive cycles, demonstrating high stability of CeFe@RDC‐3. The mechanism study reveals that the high performance of CeFe@RDC‐3 is ascribed to the Ce−Fe bimetallic synergy, uniform metal dispersion, abundant active oxygen and stabilizing effect of resin‐derived‐carbon to free radicals. This work provides prospect for a green, safe and low‐cost strategy for Baeyer‐Villiger process.
Slow Magnetization Relaxation in a Family of Triangular {CoIII2LnIII} Clusters: The Effect of Diamagnetic CoIII Ions on the LnIII Magnetic Dynamics
Authors: Armenis Alexandros S. , Vipanchi Vikram , Pantelis Konstantinos N. , Cunha‐Silva Luís , Vignesh Kuduva R. , Alexandropoulos Dimitris I. , Stamatatos Theocharis C. 
Published: August 2023

AbstractThe first use of the Schiff base chelate N‐naphthalidene‐o‐aminophenol (naphH2) in Co/Ln chemistry has afforded a family of isostructural [CoIII2LnIII(OMe)2(naph)2(O2CMe)3(MeOH)2] (Ln=Tb, Dy and Er) complexes, revealing a rare {CoIII2Ln(μ3‐OMe)}8+ triangular core composed of two diamagnetic CoIII ions and a 4f‐ion with slightly distorted square antiprismatic geometry. Alternating current (ac) magnetic susceptibility studies revealed that {Co2Dy}, and its magnetic diluted analogue {Co2Dy0.05Y0.95}, behave as mononuclear single‐molecule magnets (SMMs) with similar energy barriers for the magnetization reversal, Ueff, of ~85‐90 K. SMM properties were also detected for {Co2Er}, with the compound exhibiting a Ueff of 18.7 K under an applied magnetic field of 800 Oe. To interpret the experimental magnetic results, ab initio CASSCF/RASSI‐SO and DFT calculations were performed as a means of exploring the single‐ion characteristics of LnIII ions and comprehend the role of the diamagnetic CoIII ions in the magnetization relaxation of the three heterometallic compounds.
Solid‐State [4+4] Cycloaddition and Cycloreversion with Use of Unpaired Hydrogen‐Bond Donors to Achieve Solvatomorphism and Stabilization
Authors: George Gary C. , Hutchins Kristin M. 
Published: August 2023

AbstractThe crystal structure of a commercially available anthracene derivative, anthracene‐9‐thiocarboxamide, is reported here for the first time. The compound undergoes a [4+4] cycloaddition in the solid state to afford facile synthesis of the cycloadduct (CA). The cycloaddition is also reversible in the solid state using heat or mechanical force. Due to the presence of unpaired, strong hydrogen‐bond donor atoms on the CA, significant solvatomorphism is achieved, and components of the solvatomorphs self‐assemble into four different classes of supramolecular structures. The CA readily crystallizes with a variety of structurally‐diverse solvents including those containing oxygen‐, nitrogen‐, or pi‐acceptors. Some of the solvents the CA crystallized with include thiophene, benzene, and the three xylene isomers; thus, the CA was employed in industrially‐relevant solvent separation. However, in competition studies, the CA did not exhibit selectivity. Lastly, it is demonstrated that the CA crystallizes with vinyl‐containing monomers and is currently the only compound that crystallizes with both widely used monomers 4‐vinylpyridine and styrene. Solid‐state complexation of the CA with the monomers affords over a 50 °C increase in the monomer's thermal stabilities. The strategy of designing molecules with unused donors can be applied to achieve separations or volatile liquid stabilization.
Dysregulation of mTOR by tau in Alzheimer's disease
Authors: Bloom George S. , Norambuena Andrés 
Published: August 2023

AbstractTau was discovered in the mid 1970's as a microtubule‐associated protein that stimulates tubulin polymerization, and subsequently was shown to be expressed primarily in neurons, where it is most concentrated in axons. Interest in tau rose by the late 1980's, when it was shown to be the principal subunit of the neurofibrillary tangles (NFTs) that accumulate in Alzheimer's disease (AD) brain, and achieved new heights by the late 1990's, when numerous tau mutations were found to be highly penetrant for AD‐related disorders that also are associated with NFTs and came to be known as non‐Alzheimer's tauopathies. The role of tau in neurodegeneration is far more complex than whatever effects on neurons may be caused by NFTs, however, and here we review our work on dysregulation of mTOR by tau in AD. mTOR is a protein kinase and master regulator of myriad aspects of cellular behavior. We have defined a complex signaling network whereby aberrant tau phosphorylation provoked by amyloid‐β oligomers (AβOs), the building blocks of the amyloid plaques that form in AD brain, cause post‐mitotic neurons to re‐enter the cell cycle, but to die eventually instead of dividing, which may account for most neuron death in AD. Remarkably, we found that this same neuronal signaling network also poisons a fundamental cell biological process that we discovered, nutrient‐induced mitochondrial activation, or NiMA. Tau‐dependent cell cycle re‐entry and NiMA inhibition occur in cultured neurons within a few hours of exposure to AβOs, and thus may represent seminal processes in AD pathogenesis.
Cooperative Sensitization Upconversion in Ytterbium(III)‐Based Eosin Lake Pigments
Authors: Cevallos‐Toledo Rita B. , Bellezza Delia , Ferrera‐González Juan , Giussani Angelo , Ortí Enrique , González‐Béjar María , Pérez‐Prieto Julia 
Published: August 2023

AbstractMaterials based on organic chromophores and lanthanides able to transform low‐energy photons, specifically near‐infrared (NIR) photons, into higher energy photons to eventually lead to long‐lived sensitized emission of the dye are highly desirable. Cooperative sensitization (CS) upconversion has only been accomplished for lanthanide‐based clusters. We used here the eosin Y (EOS) dianion and Yb3+ (EOS‐Yb), and demonstrate the efficient CS emission of the dye after NIR excitation. Remarkably, the EOS dianion emission exhibits a nearly linear dependence on the EOS‐Yb concentration and a quadratic dependence on the laser power density. The emission is non‐sensitive to oxygen and its lifetime lasts about 1.76 μs and 12 μs in DMSO and DMSO‐d6, respectively. Moreover, the effect of temperature (293–363 K range) on the EOS‐Yb 1H NMR spectroscopic shifts demonstrates the reversible dynamic nature of the material.
Compare_Genomes: A Comparative Genomics Workflow to Streamline the Analysis of Evolutionary Divergence Across Eukaryotic Genomes
Authors: Paril Jefferson , Zare Tannaz , Fournier‐Level Alexandre 
Published: August 2023

AbstractThe dawn of cost‐effective genome assembly is enabling deep comparative genomics to address fundamental evolutionary questions by comparing the genomes of multiple species. However, comparative genomics analyses frequently deploy multiple, often purpose‐built frameworks, limiting their transferability and replicability. Here, we present compare_genomes, a transferable and extensible comparative genomics workflow package we developed that streamlines the identification of orthologous families within and across eukaryotic genomes and tests for the presence of several mechanisms of evolution (gene family expansion or contraction and substitution rates within protein‐coding sequences). The workflow is available for Linux, written as a Nextflow workflow that calls established genomics and phylogenetics tools to streamline the analysis and visualization of eukaryotic genome divergence. This workflow is freely available at https://github.com/jeffersonfparil/compare_genomes, distributed under the GNU General Public License version 3 (GPLv3). © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol: Comparative genomics with Nextflow and Conda
Amyloid beta plaque accumulation with longitudinal [18F]AZD4694 PET
Authors: Therriault Joseph , Lussier Firoza Z. , Tissot Cécile , Chamoun Mira , Stevenson Jenna , Rahmouni Nesrine , Pallen Vanessa , Bezgin Gleb , Servaes Stijn , Kunach Peter , Wang Yi‐Ting , Fernandez‐Arias Jaime , Vermeiren Marie , Pascoal Tharick A. , Massarweh Gassan , Vitali Paolo , Soucy Jean‐Paul , Saha‐Chaudhuri Paramita , Gauthie Serge , Rosa‐Neto Pedro 
Published: August 2023

AbstractIntroduction[18F]AZD4694 is an amyloid beta (Aβ) imaging agent used in several observational studies and clinical trials. However, no studies have yet published data on longitudinal Aβ accumulation measured with [18F]AZD4694.MethodsWe assessed 146 individuals who were evaluated with [18F]AZD4694 at baseline and 2‐year follow‐up. We calculated annual rates of [18F]AZD4694 change for clinically defined and biomarker‐defined groupsResultsCognitively unimpaired (CU) older adults displayed subtle [18F]AZD4694 standardized uptake value ratio (SUVR) accumulation over the follow‐up period. In contrast, Aβ positive CU older adults displayed higher annual [18F]AZD4694 SUVR increases. [18F]AZD4694 SUVR accumulation in Aβ positive mild cognitive impairment (MCI) and dementia was modest across the neocortexDiscussionLarger increases in [18F]AZD4694 SUVR were observed in CU individuals who had abnormal amyloid positron emission tomography levels at baseline. [18F]AZD4694 can be used to monitor Aβ levels in therapeutic trials as well as clinical settings, particularly prior to initiating anti‐amyloid therapies.
Cytopathological differential diagnosis of malignant tumor cells in the cerebrospinal fluid: A retrospective analysis
Authors: Ruotolo Riccardo , Maffei Elisabetta , Sabbatino Francesco , Serio Bianca , Zeppa Pio , Caputo Alessandro 
Published: August 2023

AbstractLeptomeningeal metastasis is the spread of cancer to the leptomeninges and subarachnoid space and represents a dreadful complication of cancer. The most commonly responsible neoplasms are high‐grade lymphomas, leukemias, and some solid tumors, chiefly breast and lung cancer as well as melanoma. Herein we report our ten‐year retrospective experience on 715 cases of cerebrospinal fluid cytology, 21 (2.9%) of which were positive for leptomeningeal metastasis. Sample collection and processing, clinical history, interdisciplinary dialog, and ancillary techniques such as immunocytochemistry and flow cytometry are all fundamental in reaching the correct diagnosis and thus optimally caring for patients with leptomeningeal metastasis.
Prognostic value of three iron deficiency definitions in patients with advanced heart failure
Authors: Papadopoulou Charikleia , Reinhold Johannes , Grüner‐Hegge Nicolai , Kydd Anna , Bhagra Sai , Parameshwar K. Jayan , Lewis Clive , Martinez Luis , Pettit Stephen J. 
Published: August 2023

AbstractAimsThere is uncertainty about the definition of iron deficiency (ID) and the association between ID and prognosis in patients with advanced heart failure. We evaluated three definitions of ID in patients referred for heart transplantation.Methods and resultsConsecutive patients assessed for heart transplantation at a single UK centre between January 2010 and May 2022 were included. ID was defined as (1) serum ferritin concentration of <100 ng/ml, or 100–299 ng/ml with transferrin saturation <20% (guideline definition), (2) serum iron concentration ≤13 μmol/L, or (3) transferrin saturation <20%. The primary outcome measure was a composite of all‐cause mortality, urgent heart transplantation or need for mechanical circulatory support. Overall, 801 patients were included, and the prevalence of ID was 39–55% depending on the definition used. ID, defined by either serum iron or transferrin saturation, was an independent predictor of the primary outcome measure (hazard ratio [HR] 1.532, 95% confidence interval [CI] 1.264–1.944, and HR 1.595, 95% CI 1.323–2.033, respectively), but the same association was not seen with the guideline definition of ID (HR 1.085, 95% CI 0.8827–1.333). These findings were robust in multivariable Cox regression analysis. ID, by all definitions, was associated with lower 6‐min walk distance, lower peak oxygen consumption, higher intra‐cardiac filling pressures and lower cardiac output.ConclusionsIron deficiency, when defined by serum iron concentration or transferrin saturation, was associated with increased frequency of adverse clinical outcomes in patients with advanced heart failure. The same association was not seen with guideline definition of ID.
Ecotoxicity of Lead to a Phytoplankton Community: Effects of pH and Phosphorus Addition and Implications for Risk Assessment
Authors: Nys Charlotte , De Schamphelaere Karel A. C. 
Published: August 2023

Abstract
Ecological risk assessment and water quality criteria for lead (Pb) are increasingly making use of bioavailability-based approaches to account for the impact of toxicity-modifying factors, such as pH and dissolved organic carbon. For phytoplankton, which are among the most Pb-sensitive freshwater species, a Pb bioavailability model has previously been developed based on standard single-species exposures at a high phosphorus (P) concentration and pH range of 6.0 to 8.0. It is well known that P can affect metal toxicity to phytoplankton and that the pH of many surface waters can be above 8.0. We aimed to test whether the single-species bioavailability model for Pb could predict the influence of pH on Pb toxicity to a phytoplankton community at both low and high P supply. A 10-species phytoplankton community was exposed to Pb for 28 days at two different pH levels (7.2 and 8.4) and two different P supply levels (low and high, i.e., total P input 10 and 100 µg/L, respectively) in a full factorial 2 × 2 test design. We found that the effects of total Pb on three community-level endpoints (biodiversity, community functioning, and community structure) were highly dependent on both pH and P supply. Consistent lowest-observed-effect concentrations (LOECs) ranged between 21 and &gt;196 µg total Pb/L and between 10 and &gt;69 µg filtered Pb/L. Long-term LOECs were generally higher, that is, 69 µg total Pb/L (42 µg filtered Pb/L) or greater, across all endpoints and conditions, indicating recovery near the end of the exposure period, and suggesting the occurrence of acclimation to Pb and/or functional redundancy. The highest toxicity of Pb for all endpoints was observed in the pH 7.2 × low P treatment, whereas the pH 8.4 × low P and pH 8.4 × high P treatment were the least sensitive treatments. At the pH 7.2 × high P treatment, the algal community showed an intermediate Pb sensitivity. The effect of pH on the toxicity of filtered Pb could not be precisely quantified because for many endpoints no effect was observed at the highest Pb concentration tested. However, the long-term LOECs (filtered Pb) at low P supply suggest a decrease in Pb toxicity of at least 1.6-fold from pH 7.2 to 8.4, whereas the single-species algal bioavailability model predicted a 2.5-fold increase. This finding suggests that bioavailability effects of pH on Pb toxicity cannot be extrapolated as such from the single species to the community level. Overall, our data indicate that, although the single-species algal Pb bioavailability model may not capture pH effects on Pb ecotoxicity in multispecies systems, the bioavailability-based hazardous concentration for 5% of the species was protective of long-term Pb effects on the structure, function, and diversity of a phytoplankton community in a relevant range of pH and P conditions. Environ Toxicol Chem 2023;42:2684–2700. © 2023 SETAC
Socioeconomic disparities in treatment and survival in patients with hypopharyngeal malignancy
Authors: Agarwal Pratima , Bloom Jacob , Zhou Yinfeng , Zhao Runqi , Huang Simu , Yajima Masanao , Devaiah Anand K. 
Published: August 2023

AbstractBackgroundThis retrospective study utilizes The Surveillance, Epidemiology, and End Results database to investigate socioeconomic factors leading to treatment disparities in hypopharyngeal malignancy.MethodsTreatment was compared to National Cancer Care Network guidelines. Novel analyses, including logistic modeling, allowed survival analysis and identification of socioeconomic variables not previously considered in staging and management guidelines.ResultsBlack and older patients, and residence in low‐income areas predict lower likelihood of standard therapy (p < 0.05). Early‐stage disease and standard therapy correlate with improved survival (p < 0.001). Medicaid, advanced age, advanced disease, and treatment outside of consensus guidelines correlated with lower survival (p < 0.0001).ConclusionsThere are clear socioeconomic factors impacting treatment and survival in hypopharyngeal malignancies. Standard therapy affords superior survival rate. Black, low socioeconomic status, and older patients are less likely to receive standard therapy. Education and language isolation do not predict treatment or survival. Understanding these discrepancies is paramount to palliating disparities in healthcare.
Synthesis, characterization, and biological properties of novel Schiff bases containing pentafluorophenyl hydrazine
Authors: Hamurcu Fatma 
Published: August 2023

AbstractIn the present study, new Schiff bases derived from pentafluorophenyl‐hydrazine (L1, L2, L3, L4) were synthesized and their structures were characterized by 1H nuclear magnetic resonance spectroscopy (NMR), 13C NMR, 19F NMR, fourier transform infrared spectroscopy, and elemental analysis methods. Then, the anticancer activities of the obtained compounds were investigated using three human cancer cell lines (A2780, over; Caco‐2, colon; and HT‐29 colon carcinoma cell lines). According to the obtained cytotoxicity results, compound number L4 was found to have the highest anticancer activity in A2780 (over) and Caco‐2 (colon) cell lines. Furthermore, in silico, ADMET properties, where studies play an important role in the development and prediction of drug compounds, were calculated using web‐based platforms. In addition, molecular docking studies were performed to evaluate the binding interactions between the synthesized pentafluorophenyl‐hydrazone compounds and the MDM2 protein (4JSC). Both in vitro and in silico results showed that the synthesized compounds could act as potent anticancer agents.
Aldehyde dehydrogenase 2 deficiency reinforces formaldehyde‐potentiated pro‐inflammatory responses and glycolysis in macrophages
Authors: Ma Huijuan , Lou Kaiyan , Shu Qi , Song Xiaodong , Xu Huan 
Published: August 2023

AbstractAldehyde dehydrogenase 2 (ALDH2) deficiency caused by genetic variant is present in more than 560 million people of East Asian descent, which can be identified by apparent facial flushing from acetaldehyde accumulation after consuming alcohol. Recent findings indicated that ALDH2 also played a critical role in detoxification of formaldehyde (FA). Our previous studies showed that FA could enhance macrophagic inflammatory responses through the induction of HIF‐1α‐dependent glycolysis. In the present study, pro‐inflammatory responses and glycolysis promoted by 0.5 mg/m3 FA were found in mice with Aldh2 gene knockout, which was confirmed in the primary macrophages isolated from Aldh2 gene knockout mice treated with 50 μM FA. FA at 50 and 100 μM also induced stronger dose‐dependent increases of pro‐inflammatory responses and glycolysis in RAW264.7 murine macrophages with knock‐down of ALDH2, and the enhanced effects induced by 50 μM FA was alleviated by inhibition of HIF‐1α in RAW264.7 macrophages with ALDH2 knock‐down. Collectively, these results clearly demonstrated that ALDH2 deficiency reinforced pro‐inflammatory responses and glycolysis in macrophages potentiated by environmentally relevant concentration of FA, which may increase the susceptibility to inflammation and immunotoxicity induced by environmental FA exposure.
The pre‐ and postembryonic development of Artemia franciscana (Anostraca: Artemiidae)
Authors: Thirunavukkarasu Subramani , Shadrin Nickolai , Munuswamy Natesan 
Published: August 2023

AbstractArtemia franciscana is a universal live feed in aquaculture, and it has been reported as an invasive species in many Asian hypersaline ecosystems. The present observations illustrated the pre‐ and postembryonic development stages of the A. franciscana population confined to the Indian saltern of Kelambakkam. We observed their growth patterns during various hydration periods with specific time intervals. Results showed differences in the development stages with respect to unique identity. Interestingly, a period of hydration showed notable cellular movement toward clockwise positions in the hydrating cysts. After 10 h of hydration, blastocoel appeared, accelerating the dynamic route of nuclei movement. At the end of the invagination, the embryo burst out of the cyst, and a sequence of emerging stages was noted. With reference to light microscopic observations, a series of developmental stages were observed, and each instar was documented by developing limb buds of nauplii. Excitingly, the 10th and 11th instar stages reveal sexual differentiation between male and female individuals. Thus, the laboratory culture study clearly documented the different developmental stages with their specific characteristic features. However, further molecular study would provide a cellular basis for understanding the early development of A. franciscana.