bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transparent and Reusable Nanostencil Lithography for Organic–Inorganic Hybrid Perovskite Nanodevices
Authors: Han Bin , Liu Bo , Wang Guanghui , Qiu Qi , Wang Zhe , Xi Yuying , Cui Yanxia , Ma Shufang , Xu Bingshe , Hsu Hsien‐Yi 
Published: April 2023

AbstractOrganic—inorganic hybrid perovskites have attracted considerable attention for developing novel optoelectronic devices owing to their excellent photoresponses. However, conventional nanolithography of hybrid perovskites remains a challenge because they undergo severe damage in standard lithographic solvents, which prohibits device miniaturization and integration. In this study, a novel transparent stencil nanolithography (t‐SL) technique is developed based on focused ion beam (FIB)‐assisted polyethylene terephthalate (PET) direct patterning. The proposed t‐SL enables ultrahigh lithography resolution down to 100 nm and accurate stencil mask alignment. Moreover, the stencil mask can be reused more than ten times, which is cost‐effective for device fabrication. By applying this lithographic technique to hybrid perovskites, a high‐performance 2D hybrid perovskite heterostructure photodetector is fabricated. The responsivity and detectivity of the proposed heterostructure photodetector can reach up to 28.3 A W−1 and 1.5 × 1013 Jones, respectively. This t‐SL nanolithography technique based on FIB‐assisted PET direct patterning can effectively support the miniaturization and integration of hybrid‐perovskite‐based electronic devices.
Development and Implementation of Microbial Antifreeze Protein Based Coating for Anti‐Icing
Authors: Muganlı Zülal , Saeidiharzand Shaghayegh , Rekuviene Regina , Samaitis Vykintas , Jankauskas Audrius , Koşar Ali , Gharib Ghazaleh , Sadaghiani Abdolali 
Published: April 2023

AbstractIce formation on a solid surface is a major challenge in industrial applications, it causes higher energy consumption and performance deterioration and may lead to catastrophic results. The preparation of anti‐icing surfaces to prohibit ice accumulation on a surface is crucial to reduce operational costs and to extend the surface's lifetime. The utilization of cryoprotectants to obtain anti‐icing surfaces is an effective method and is applicable in multiple fields. Antifreeze proteins (AFPs) are natural cryoprotectants to obtain anti‐icing surfaces, which have the ability to decrease the freezing point and to prevent ice‐crystal growth via thermal hysteresis (TH) and ice recrystallization inhibition (IRI). This study reports the molecular cloning, expression, and production of AFP protein from Escherichia coli (E. Coli). This wok also demonstrates the activity of coated AFP on aluminum surfaces. The expressed AFP is immobilized on aluminum surfaces treated by oxygen plasma. The coated AFP exhibits promising antifreeze activity with a high anti‐icing ability on aluminum surfaces in the size of evaporator fins (40 × 40 cm). The outcome of this study provides new insights into the biotechnological implementation of AFPs to various industrial applications for energy‐saving and higher performance.
The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis
Authors: He Xuyan , Ge Chaodong , Xia Jun , Xia Zhidan , Zhao Lu , Huang Sicong , Wang Rong , Pan Jianwei , Cheng Tao , Xu Peng‐Fei , Wang Fudi , Min Junxia 
Published: April 2023

AbstractThe role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in hematopoiesis. The results show that in zebrafish, Slc39a10 is a key regulator of the response to zinc deficiency. Surprisingly, both slc39a10 mutant zebrafish and hematopoietic Slc39a10‐deficient mice develop a more severe form of impaired hematopoiesis than animals lacking transferrin receptor 1, a well‐characterized iron gatekeeper, indicating that zinc plays a larger role than iron in hematopoiesis, at least in early hematopoietic stem cells (HSCs). Furthermore, it is shown that loss of Slc39a10 causes zinc deficiency in fetal HSCs, which in turn leads to DNA damage, apoptosis, and G1 cell cycle arrest. Notably, zinc supplementation largely restores colony formation in HSCs derived from hematopoietic Slc39a10‐deficient mice. In addition, inhibiting necroptosis partially restores hematopoiesis in mouse HSCs, providing mechanistic insights into the requirement for zinc in mediating hematopoiesis. Together, these findings indicate that SLC39A10 safeguards hematopoiesis by protecting against zinc deficiency‐induced necroptosis, thus providing compelling evidence that SLC39A10 and zinc homeostasis promote the development of fetal HSCs. Moreover, these results suggest that SLC39A10 may serve as a novel therapeutic target for treating anemia and zinc deficiency‐related disorders.
Glutathione‐Scavenging Nanoparticle‐Mediated PROTACs Delivery for Targeted Protein Degradation and Amplified Antitumor Effects
Authors: Liu Hai‐Jun , Chen Wei , Wu Gongwei , Zhou Jun , Liu Chuang , Tang Zhongmin , Huang Xiangang , Gao Jingjing , Xiao Yufen , Kong Na , Joshi Nitin , Cao Yihai , Abdi Reza , Tao Wei 
Published: April 2023

AbstractPROteolysis TArgeting Chimeras (PROTACs) are an emerging class of promising therapeutic modalities that selectively degrade intracellular proteins of interest by hijacking the ubiquitin‐proteasome system. However, the lack of techniques to efficiently transport these degraders to targeted cells and consequently the potential toxicity of PROTACs limit their clinical applications. Here, a strategy of nanoengineered PROTACs, that is, Nano‐PROTACs, is reported, which improves the bioavailability of PROTACs and maximizes their capacity to therapeutically degrade intracellular oncogenic proteins for tumor therapy. The Nano‐PROTACs are developed by encapsulating PROTACs in glutathione (GSH)‐responsive poly(disulfide amide) polymeric (PDSA) nanoparticles and show that ARV@PDSA Nano‐PROTAC, nanoengineered BRD4 degrader ARV‐771, improves BRD4 protein degradation and decreases the downstream oncogene c‐Myc expression. Benefiting from the GSH‐scavenging ability to amply the c‐Myc‐related ferroptosis and cell cycle arrest, this ARV@PDSA Nano‐PROTACs strategy shows superior anti‐tumor efficacy with a low dose administration and good biocompatibility in vivo. The findings reveal the potential of the Nano‐PROTACs strategy to treat a broad range of diseases by dismantling associated pathogenic proteins.
F‐Doped Carbon Nanoparticles‐Based Nucleation Assistance for Fast and Uniform Three‐Dimensional Zn Deposition
Authors: Xiong Lingyun , Kim Youjoong , Fu Hao , Han Weiwei , Yang Woochul , Liu Guicheng 
Published: April 2023

AbstractAqueous Zn metal‐based batteries have considerable potential as energy storage system; however, their application is extremely limited by dendrite development and poor reversibility. In this study, to overcome both challenges, F‐doped carbon nanoparticles (FCNPs) are uniformly constructed on substrates (Ti, Zn, Cu, and steel) by a plasma‐assisted surface modification, which endows reversible and uniform deposition of Zn metal. FCNPs with high surface charge density act as nucleation assistors and form numerous homogenous Zn nucleation sites toward Zn 3D growth, which improves Zn plating kinetic and results in uniform Zn deposition. Furthermore, the ZnF2 solid electrolyte interface generated during cycling contributes to rapid mass transfer and enhances Zn reversibility, but also suppresses the side reaction. Accordingly, the half‐cell of P‐Ti coupled with Zn exhibits an average Coulombic efficiency of 99.47% with 500 cycles. The symmetric cell of the P‐Zn anode presents a lifespan of over 1500 h at the current density of 5 mA cm−2. Notably, the cell works for 100 h at 50 mA cm−2. It is believed that this ingenious surface modification broadens revolutionary methods for uniform metallic deposition, as well as the dendrite‐free rechargeable batteries system.
Substrate‐Free Transfer of Large‐Area Ultra‐Thin Electronics
Authors: Oliveira Hugo De Souza , Catania Federica , Lanthaler Albert Heinrich , Carrasco‐Pena Alejandro , Cantarella Giuseppe , Münzenrieder Niko 
Published: April 2023

AbstractInnovation in materials and technologies has promoted the fabrication of thin‐film electronics on substrates previously considered incompatible because of their chemical or mechanical properties. Indeed, conventional fabrication processes, typically based on photolithography, involve solvents and acids that might harm fragile or exotic substrates. In this context, transfer techniques define a route to overcome the issues related to the nature of the substrate by using supportive carriers in the electronics stack that mitigate or avoid any damages during the fabrication process. Here, a substrate‐free approach is presented for the transfer of ultra‐thin electronics (<150nm‐thick) where no additional layer besides the electronics one remains on the final substrate. Devices are transferred on several surfaces showing good adhesion and an average performance variation of 27%. Furthermore, a sensor bent to a radius of 15.25µm, shows variation in performance of 5%. The technique can also be sequentially repeated for the fabrication of stacked electronics, enabling the development of ultra‐thin devices, compliant on unconventional surfaces.
Low Leakage in High‐k Perovskite Gate Oxide SrHfO3
Authors: Kim Juhan , Song Dowon , Yun Hwanhui , Lee Jaehyeok , Kim Jae Ha , Kim Jae Hoon , Kim Bongju , Char Kookrin 
Published: April 2023

AbstractReducing the leakage current through the gate oxide is becoming increasingly important for power consumption reduction as well as reliability in integrated circuits as the semiconducting devices continue to scale down. Here, this work reports on the high‐k dielectric SrHfO3(SHO) based devices with ultralow leakage current density via pulsed laser deposition (PLD). The ultralow current density is achieved by optimizing the growth conditions and the associated structural properties. In the optimized conditions, the dielectric properties of the 50‐nm‐thick SHO capacitors are measured: high dielectric constant (κ = 32), low leakage current density (<10−8A cm−2at 2 MV cm−1), and large breakdown field (EBD > 4 MV cm−1). The surprisingly low leakage current density of SHO is ascribed to the large bandgap (≈6 eV), the large conduction band offset (CB offset > 3 eV) with respect to the semiconductor, and the low density of defect states inside the bandgap. The optimized SHO dielectric with high dielectric constant and ultralow leakage current density is proposed for future low‐power consumption devices based on Si as well as perovskite oxide semiconductors.
Role of reduction gastrectomy in patients with gastric cancer with a single non‐curable factor: Supplementary analysis of REGATTA trial
Authors: Terashima Masanori , Fujitani Kazumasa , Yang Han‐Kwang , Mizusawa Junki , Tsujinaka Toshimasa , Nakamura Kenichi , Katayama Hiroshi , Lee Hyuk‐Joon , Lee Jun Ho , An Ji‐Yeong , Takagane Akinori , Park Young‐Kyu , Choi Seung Ho , Song Kyo Young , Ito Seiji , Park Do Joong , Jin Sung‐Ho , Boku Narikazu , Yoshikawa Takaki , Sasako Mitsuru ,   REGATTA study investigators
Published: April 2023

AbstractBackgroundREGATTA trial failed to demonstrate the survival benefit of reduction gastrectomy in patients with advanced gastric cancer with a single non‐curable factor. However, a significant interaction was found between the treatment effect and tumor location in the subset analysis. Additionally, the treatment effect appeared to be different between Japan and Korea. This supplementary analysis aimed to elucidate the effect of reduction surgery based on tumor location and country.MethodsMultivariable Cox regression analyses in each subgroup were performed to estimate the hazard ratio (HRadj), including the following variables as explanatory variables: country, age, sex, incurable factor, cT, cN, primary tumor, performance status, histological type, and macroscopic type.ResultsPatients (95 in Japan and 80 in Korea) were randomized to chemotherapy alone (86 patients) or gastrectomy plus chemotherapy (89 patients). The subgroup analysis according to the country revealed a worse overall survival in gastrectomy plus chemotherapy arm in Japan (hazard ratio: 1.32, 95% confidence interval: 0.85–2.05), but not in Korea (hazard ratio: 0.85.95% confidence interval: 0.52–1.40). Overall survival was better in distal gastrectomy plus chemotherapy compared with chemotherapy alone (hazard ratio = 0.69, 95% confidence interval: 0.42–1.13), and worse in total gastrectomy plus chemotherapy compared with chemotherapy alone (hazard ratio = 1.34, 95% CI: 0.93–1.94), which was more remarkable in Korea than in Japan.ConclusionsPrimary chemotherapy is a standard of care for advanced gastric cancer; however, the survival benefits from reduction by distal gastrectomy remained controversial.
Overweight and obesity in adulthood, sociodemographic factors, lifestyle, and the early burden of noncommunicable diseases among Americans: NHANES 2007–2018
Authors: dos Santos Pereira Débora Borges , Conde Wolney Lisboa 
Published: April 2023

AbstractObjectivesTo evaluate the association between nutritional status in early adulthood and the burden of noncommunicable diseases (NCDs); To evaluate the influence of sociodemographic factors and lifestyle on the outcomes of BMI kg/m2 ≤24.9, ≥25.0, and ≥30.0; to estimate the population attributable fraction (PAF) to BMI elevated at 25 years old in the burden of NCDs in American adults.MethodsWe used data from 15 721 American adults participating in the National Health and Nutrition Examination Survey from 2007 to 2018. The Hazard Ratio (HR), Incidence Rate Ratio (IRR), and 95% confidence intervals (CI) were estimated in the proportional risk regression models of Cox (entire population) and Poisson (restricted to non‐patients), respectively. The proportionality of the risk between the burden of NCDs and BMI at 25 years old was drawn by the Kaplan–Meier curve, and the PAF was calculated. All analyses were adjusted taking into account the sample weights.ResultsHealth disparities (sex, age, race/ethnicity, education, poverty index, and education level), and lifestyle (physical activity, smoking, and alcohol consumption) influenced the current nutritional status. Cumulative survival in overweight and obese groups decreased considerably over time (p < .0001). Being overweight and obese in adulthood may increase the risk of early NCDs (HR: 1.68, 95% CI: 1.54–1.84 and HR: 2.87, 95% CI: 2.56–3.21, respectively). About 22.72% (95% CI: 19.99–25.36, p < .001) of the burden NCDs could have been avoided if overweight at age 25 had been prevented.ConclusionsMonitoring weight change from young adulthood can provide a sensitive and useful clinical measure for early detection of adverse trends in NCDs risk.
Expanded phenotypic and hematologic abnormalities beyond bone marrow failure in MECOM‐associated syndromes
Authors: Lozano Chinga Michell M. , Bertuch Alison A. , Afify Zeinab , Dollerschell Kaylee , Hsu Joanne I. , John Tami D. , Rao Emily S. , Rowe Robert Grant , Sankaran Vijay G. , Shimamura Akiko , Williams David A. , Nakano Taizo A. 
Published: April 2023

AbstractThe MECOM gene encodes multiple protein isoforms that are essential for hematopoietic stem cell self‐renewal and maintenance. Germline MECOM variants have been associated with congenital thrombocytopenia, radioulnar synostosis and bone marrow failure; however, the phenotypic spectrum of MECOM‐associated syndromes continues to expand and novel pathogenic variants continue to be identified. We describe eight unrelated patients who add to the previously known phenotypes and genetic defects of MECOM‐associated syndromes. As each subject presented with unique MECOM variants, the series failed to demonstrate clear genotype‐to‐phenotype correlation but may suggest a role for additional modifiers that affect gene expression and subsequent phenotype. Recognition of the expanded hematologic and non‐hematologic clinical features allows for rapid molecular diagnosis, early identification of life‐threatening complications, and improved genetic counseling for families. A centralized international publicly accessible database to share annotated MECOM variants would advance their clinical interpretation and provide a foundation to perform functional MECOM studies.
KCNT2‐Related Disorders: Phenotypes, Functional, and Pharmacological Properties
Authors: Cioclu Maria Cristina , Mosca Ilaria , Ambrosino Paolo , Puzo Deborah , Bayat Allan , Wortmann Saskia B. , Koch Johannes , Strehlow Vincent , Shirai Kentaro , Matsumoto Naomichi , Sanders Stephan J. , Michaud Vincent , Legendre Marine , Riva Antonella , Striano Pasquale , Muhle Hiltrud , Pendziwiat Manuela , Lesca Gaetan , Mangano Giuseppe Donato , Nardello Rosaria ,   KCNT2‐study group, Lemke Johannes R. , Møller Rikke S. , Soldovieri Maria Virginia , Rubboli Guido , Taglialatela Maurizio 
Published: April 2023

ObjectivePathogenic variants in KCNT2 are rare causes of developmental epileptic encephalopathy (DEE). We herein describe the phenotypic and genetic features of patients with KCNT2‐related DEE, and the in vitro functional and pharmacological properties of KCNT2 channels carrying 14 novel or previously untested variants.MethodsTwenty‐five patients harboring KCNT2 variants were investigated: 12 were identified through an international collaborative network, 13 were retrieved from the literature. Clinical data were collected and included in a standardized phenotyping sheet. Novel variants were detected using exome sequencing and classified using ACMG criteria. Functional and pharmacological studies were performed by whole‐cell electrophysiology in HEK‐293 and SH‐SY5Y cells.ResultsThe phenotypic spectrum encompassed: (a) intellectual disability/developmental delay (21/22 individuals with available information), ranging from mild to severe/profound; (b) epilepsy (15/25); (c) neurological impairment, with altered muscle tone (14/22); (d) dysmorphisms (13/20). Nineteen pathogenic KCNT2 variants were found (9 new, 10 reported previously): 16 missense, 1 in‐frame deletion of a single amino acid, 1 nonsense, and 1 frameshift. Among tested variants, 8 showed gain‐of‐function (GoF), and 6 loss‐of‐function (LoF) features when expressed heterologously in vitro. Quinidine and fluoxetine blocked all GoF variants, whereas loxapine and riluzole activated some LoF variants while blocking others.InterpretationWe expanded the phenotypic and genotypic spectrum of KCNT2‐related disorders, highlighting novel genotype–phenotype associations. Pathogenic KCNT2 variants cause GoF or LoF in vitro phenotypes, and each shows a unique pharmacological profile, suggesting the need for in vitro functional and pharmacological investigation to enable targeted therapies based on the molecular phenotype. ANN NEUROL 2023;94:332–349
Ionic Nickel Embedded in Ceria with High Specific CO2 Methanation Activity
Authors: Barreau Mathias , Salusso Davide , Li Juan , Zhang Jinming , Borfecchia Elisa , Sobczak Kamil , Braglia Luca , Gallet Jean‐Jacques , Torelli Piero , Guo Hua , Lin Sen , Zafeiratos Spyridon 
Published: April 2023

AbstractCO2 hydrogenation to methane is gaining increasing interest as one of the most promising ways to store intermittent renewable energy in the form of chemical fuels. Ni particles supported on CeO2 represent a highly efficient, stable and inexpensive catalyst for this reaction. Herein, Ni‐doped CeO2 nanoparticles were tested for CO2 methanation showing an extremely high Ni mass‐specific activity and CH4 selectivity. Operando characterization reveals that this performance is tightly associated with ionic Νi and Ce3+ surface sites, while formation of metallic Ni does not seem to considerably promote the reaction. Theoretical calculations confirmed the stability of interstitial ionic Ni sites on ceria surfaces and highlighted the role of Ce‐O frustrated Lewis pair (FLP), Ni‐O classical Lewis pair (CLP) and Ni‐Ce pair sites to the activation of H2 and CO2 molecules. To a large extent, the theoretical predictions were validated by in situ spectroscopy under H2 and CO2 : H2 gaseous environments.
Copper(II)/polyimide linked covalent organic framework as a powerful catalyst for the solvent‐free microwave irradiation‐based synthesis of 2,4,5‐trisubstituted imidazoles
Authors: Sedaghat Mahnaz , Moeinpour Farid , Mohseni‐Shahri Fatemeh S. 
Published: April 2023

AbstractCopper(II)/polyimide‐linked covalent organic frameworks under solvent‐free and microwave‐assisted conditions have been used in an efficient one‐pot protocol for the preparation of 2,4,5‐trisubstituted imidazoles via benzil, aromatic aldehydes and ammonium acetate. By applying solvent‐free conditions and microwave irradiation, three‐component condensation provides safe operations, low pollution, quick access to products, and an easy set‐up. As a result of its reusability, the catalyst can also be reutilized for many runs without missing any activity.
Nanoemulsions for increased penetrability and sustained release of leishmanicidal compounds
Authors: García Darlyn J. , Fernández‐Culma Maritza , Upegui Yulieth A. , Ríos‐Vásquez Luz A. , Quiñones Wiston , Ocampo‐Cardona Rogelio , Echeverri Fernando , Vélez Iván D. , Robledo Sara M. 
Published: April 2023

AbstractIn the last decade, the World Health Organization has driven the development of drugs for topical use in patients with cutaneous leishmaniasis (CL), the most prevalent clinical form of leishmaniasis, a neglected tropical disease. The chemicals C6I, TC1, and TC2 were reported as promising antileishmanial drugs. We aimed to develop a topical nanoformulation that enhances the advantageous effect of C6I, TC1, and TC2, guaranteeing higher stability and bioavailability of the pharmacologically active components through the topical route. Nanoemulsions were prepared by ultrasonication based on oleic acid (0.5 g). A relation of Tween®‐80/ethanol (1:3) and water was obtained; physicochemical characterization of all formulations was performed, and the preliminary stability and transdermal penetration of these nanoemulsions were also investigated. Newtonian‐type fluids with high load capacity, 147–273 nm globule size, and −15 to −18 mV zeta potential were obtained with differential permeability rates in the first pig ear skin assay, first‐order kinetics‐release model for C6I, and Weibull for TC1 and TC2. The nanoemulsion showed good stability, high encapsulation efficiency, and higher leishmanicidal activity against Leishmania braziliensis with lower cytotoxicity in U937 macrophages. In conclusion, nanoemulsions of ethanol–oleic acid/Tween®‐80 increase the activity of compounds with leishmanicidal activity by increasing their penetration and sustained release.
Use of macroalgal waste from the carrageenan industry as feedstock for the production of polyhydroxybutyrate
Authors: Romero‐Vargas Agustín , Gallé Ana , Blandino Ana , Romero‐García Luis I 
Published: April 2023

AbstractThe industrial waste generated in the extraction of carrageenan from red seaweed, Eucheuma spinosum, was tested in this study to produce fermentable sugars that could be used for the production of high‐value‐bioproducts with a biorefinery approach. A sequential process was used: thermochemical pretreatment with HCl and enzymatic hydrolysis. Hydrogen chloride concentrations in the range from 0 mol L−1 to 0.5 mol L−1 and pretreatment times from 15 to 100 min were assayed. The best conditions found for pretreatment were HCl 0.3 mol L−1 for 60 min, leading to reducing sugar concentrations of 21.4 g L−1 (274 mg of reducing sugars per gram of algal residue). The hydrolysates coming from the sequential process under the pretreatment conditions of HCl 0.3 mol L−1 for 60 and 80 min have been used successfully for the production of polyhydroxyalkanoates by Cupriavidus necator. The yields of polyhydroxybutyrate were 0.21–0.26 g PHB g−1 reducing sugar consumed and the accumulation of the biopolymer was of the order of 58% dry cell weight. © 2023 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.