bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arabidopsis T‐DNA mutants affected in TRDMT1/DNMT2 show differential protein synthesis and compromised stress tolerance
Authors: Wadhwa Nikita , Kapoor Sanjay , Kapoor Meenu 
Published: August 2023

TRDMT1/DNMT2 belongs to the conserved family of nucleic acid methyltransferases. Unlike the animal systems, studies on TRDMT1/DNMT2 in land plants have been limited. We show that TRDMT1/DNMT2 is strongly conserved in the green lineage. Studies in mosses have previously shown that TRDMT1/DNMT2 plays a crucial role in modulating molecular networks involved in stress perception and signalling and in transcription/stability of specific tRNAs under stress. To gain deeper insight into its biological roles in a flowering plant, we examined more closely the previously reported Arabidopsis SALK_136635C line deficient in TRDMT1/DNMT2 function [Goll MG et al. (2006) Science 311, 395–398]. RNAs derived from Arabidopsis Dnmt2‐deficient plants lacked m5C38 in tRNAAsp. In this study, by transient expression assays we show that Arabidopsis TRDMT1/DNMT2 is distributed in the nucleus, cytoplasm and RNA‐processing bodies, suggesting a role for TRDMT1/DNMT2 in RNA metabolic processes possibly by shuttling between cellular compartments. Bright‐field and high‐resolution SEM and qPCR analysis reveal roles of TRDMT1/DNMT2 in proper growth and developmental progression. Quantitative proteome analysis by LC–MS/MS coupled with qPCR shows AtTRDMT1/AtDNMT2 function to be crucial for protein synthesis and cellular homeostasis via housekeeping roles and proteins with poly‐Asp stretches and RNA pol II activity on selected genes are affected in attrdmt1/atdnmt2. This shift in metabolic pathways primes the mutant plants to become increasingly sensitive to oxidative and osmotic stress. Taken together, our study sheds light on the mechanistic role of TRDMT1/DNMT2 in a flowering plant.
The collaborative study on the genetics of alcoholism: Sample and clinical data
Authors: Dick Danielle M. , Balcke Emily , McCutcheon Vivia , Francis Meredith , Kuo Sally , Salvatore Jessica , Meyers Jacquelyn , Bierut Laura J. , Schuckit Marc , Hesselbrock Victor , Edenberg Howard J. , Porjesz Bernice ,   COGA Collaborators, Kuperman Samuel , Kramer John , Bucholz Kathleen 
Published: August 2023

AbstractThe collaborative study on the genetics of alcoholism (COGA) is a multi‐site, multidisciplinary project with the goal of identifying how genes are involved in alcohol use disorder and related outcomes, and characterizing how genetic risk unfolds across development and in conjunction with the environment and brain function. COGA is a multi‐generational family‐based study in which probands were recruited through alcohol treatment centers, along with a set of community comparison families. Nearly 18,000 individuals from >2200 families have been assessed over a period of over 30 years with a rich phenotypic battery that includes semi‐structured psychiatric interviews and questionnaire measures, along with DNA collection and electrophysiological data on a large subset. Participants range in age from 7 to 97, with many having longitudinal assessments, providing a valuable opportunity to study alcohol use and problems across the lifespan. Here we provide an overview of data collection methods for the COGA sample, and details about sample characteristics and comorbidity. We also review key research findings that have emerged from analyses of the COGA data. COGA data are available broadly to researchers, and we hope this overview will encourage further collaboration and use of these data to advance the field.
A novel prosthesis presentation test to screen for cognitive and functional decline
Authors: Srinivasan Murali , Duong Stephan , Trombert Veronique , Kalberer Nicole , Zekry Dina , Herrmann François R. , Delavy Joris , Gold Gabriel , Müller Frauke 
Published: August 2023

Objectives and backgroundTo validate a novel screening test for cognitive and functional decline in older patients rehabilitated with complete removable dental prostheses (CRDPs).Materials and methodsEdentate old in‐patients rehabilitated with CRDPs were included in this study. Participants were requested to remove their prostheses before their intraoral examinations. The prostheses were then presented in an inverted orientation. Participants had to correct the orientation of the prostheses and insert them in the appropriate jaws. The test was repeated after the intraoral exam. Appropriate statistical models were used (⍺ = .05) to associate the test results with the participants' mini‐mental state examination (MMSE) score, functional independence measure (FIM), age and sex.ResultsAmong the 86 participants (mean‐age: 85.4 ± 6.4 years; mean MMSE: 19.8 ± 5.5; mean FIM: 77.9 ± 20.8), 21 (24.4%) failed to correctly insert the prosthesis. The prosthesis presentation test (PPT) was associated with the FIM but not the MMSE. Regression models further confirmed an association with age (P = .043), but not sex. Additional analyses revealed the PPT test is associated with the FIM's cognitive sub‐sets of memory, problem solving and social interaction.ConclusionThe PPT is a novel, simple and quick screening tool that can help detect functional difficulties in older people. It can easily be performed during an oral examination. Future studies are needed to determine whether the PPT can be used to detect deficits in executive function, as a complement to the MMSE and also as a first assessment of a patient's ability to manage dentures independently.
In family we trust—In good and bad times
Authors: Masset Philippe , Poretti Cédric , Weisskopf Jean‐Philippe 
Published: August 2023

AbstractThis short report investigates the stock market behavior of Swiss companies during the COVID‐19 pandemic. Results suggest that family firms performed better during the outbreak and post‐lockdown periods than widely‐held firms. Family firms also displayed a larger abnormal trading volume drop than widely‐held companies. In size‐sorted subsamples, the volume difference appears more pronounced for smaller firms. We explain these findings by family firms, especially smaller ones, predominantly attracting investors with a long‐term horizon. Such investors are less likely to sell during market turmoil, making family firms not only less liquid but also less sensitive to market fluctuations.
Ultrafast crystallization and sintering of Li1.3Al0.3Ti1.7(PO4)3 glass through flash sinter‐crystallization
Authors: Campos João V. , Lavagnini Isabela R. , Zallocco Vinicius M. , Jesus Lilian M. , Rodrigues Ana C. M. 
Published: August 2023

AbstractFlash sinter‐crystallization (FSC) is a new technique for concurrently crystallizing and sintering glasses, derived from flash sintering. In this study, we explore, for the first time, the use of FSC as a processing method for producing Li1.3Al0.3Ti1.7(PO4)3 (LATP) glass ceramics. Using FSC, LATP with NaSICON structure is produced at a furnace temperature as low as 460°C and a processing time of 5 min. The FSC‐processed samples with different current density limits were compared with those conventionally sinter‐crystallized (CSC) at 950°C for 1 h. We show that FSC can significantly improve the densification of LATP glass ceramics due to the volumetric high heating rate. Furthermore, the LATP samples processed by FSC exhibit superior total ionic conductivity than those processed by CSC, also surpassing the reported results for LATP with similar levels of densification. Therefore, our results suggest that FSC is a promising method for processing glass ceramics, particularly for materials with high crystallization kinetics like LATP, opening up new possibilities for the production of solid electrolytes.
The perception of patients, mothers and healthcare professionals regarding introduction of home visits for adolescents with type 1 diabetes
Authors: Kofoed Poul‐Erik , Lisbjerg Susanne , Thomsen Jane 
Published: August 2023

AbstractBackground and ObjectivesDespite advancements in diabetes management, a subgroup of patients does not achieve an acceptable level of metabolic control. To achieve treatment goals for high‐risk patients, a higher frequency of contact with healthcare professionals is essential. However, socioeconomic challenges often lead to nonattendance at the outpatient clinic. Therefore, home visits were introduced as a supplement/an alternative to consultations at the paediatric diabetes clinic. The aim of this study was to uncover the perception of patients, mothers and healthcare professionals regarding home visits versus consultations at the outpatient clinic in order to being able to improve the services offered.MethodsSemistructured interviews with patients, mothers and healthcare professionals were conducted to explore the experiences and perspectives of the concept at two paediatric diabetes clinics in Denmark. Paired t tests were used to compare the glycated hemoglobin A1c (HbA1c) levels at the start of the intervention with HbA1c 1 year before and HbA1c at the end of the intervention.ResultsBoth patients, mothers and healthcare professionals found consultations in familiar surroundings to result in stronger relationships between healthcare professionals and families, creating greater opportunities to discuss personal issues aimed at improving the outcome of diabetes. Furthermore, home visits facilitated finding alternative methods of helping patients and the families integrating diabetes into everyday life.ConclusionOverall, home visits were found to contribute toward creating a more constructive relationship. However, it was still a challenge to keep the scheduled appointments, and during this short study, no improvement in metabolic control could be observed.
Additively manufactured devices with varying designs and sizes for acquiring initial intraoral implant scans
Authors: Guirao Sergi , Llansana Ferran , Button Heather , Yilmaz Burak , Kois John C. , Revilla‐León Marta 
Published: August 2023

AbstractDental literature has reported greater intraoral scanning accuracy when implant scan bodies (ISBs) are connected compared with non‐connected methods. Initial intraoral digital implant scans are required for the fabrication of a custom framework to connect implant scan bodies (IOSFix; IOSFix Dental). This calibrated metal framework is used to acquire definitive intraoral implant scans. However, the acquisition of initial intraoral implant scans can be challenging when ISBs are not connected. This article describes a step‐by‐step technique for connecting ISBs by using additively manufactured devices to acquire initial intraoral implant scans. This technique aims to facilitate the recording of initial intraoral implant scans, provide different device designs and sizes to connect ISBs, and reduce chairside time.
Comparison of electronic versus mechanical torque‐limiting devices for dental implants: An in vitro study
Authors: Faraj Mohaad A. , Bidra Avinash S. , Taylor Thomas D. , Kuo Chia‐Ling 
Published: August 2023

AbstractPurposeTo determine the accuracy of new electronic torque‐limiting devices (ET) when compared to new and used conventional‐style beam‐type (BT) mechanical torque‐limiting devices and hand‐piece style (HS) mechanical torque‐limiting devices. The secondary purpose was to compare any difference in accuracy between new and used mechanical torque‐limiting devices, and any difference in accuracy when used on a straight versus an angled screw channel abutment.Materials And MethodsA total of five torque‐limiting devices were used to obtain 2000 readings under standardized conditions. An implant analog was fastened into a digital torque meter, to which an abutment was connected. Pre‐determined torque values of 15 Ncm and 35 Ncm were applied, and actual torque values were recorded. A straight and an angled abutment were used to record 1000 readings each using the five torque‐limiting devices. An overall Kruskal‐Wallis test was applied to compare the median deviation among devices followed by a pairwise comparison ( = 0.05).ResultsFor a target torque value of 15 Ncm on a straight abutment, the electronic device (ET) was statistically more accurate than the beam type (BT) new (p < 0.001) and used (p < 0.048) devices but less accurate than the hand‐piece style (HS) used device (p < 0.001). On an angled abutment for a target value of 15 Ncm, the electronic device (ET) was statistically more accurate than hand‐piece style (HS) new and used devices (p < 0.001). For a target torque value of 35 Ncm on a straight abutment, the ET was statistically more accurate than the HS new device (p < 0.001) but less accurate than the BT new device (p < 0.001). On an angled abutment for a target value of 35 Ncm, the electronic device (ET) was statistically less accurate than the beam‐type (BT) new device (p < 0.001), the beam‐type (BT) used device (p = 0.001), and the hand‐piece style (HS) used device (p < 0.001). The electronic device (ET) was the only device accurate within the ISO standard of accuracy of 6% for each of the target torque value/abutment design combinations. There was no statistically significant difference related to the type of abutment used (angled vs. straight).ConclusionsElectronic torque limiting devices (ET) are an acceptable method for delivering torque for implant restorations for straight and angled abutments at 15 Ncm and 35 Ncm torque values. Conventional style beam‐type (BT) mechanical torque‐limiting devices are a simple, predictable, validated, and inexpensive tool for delivering accurate torque at 15 Ncm and 35 Ncm torque values. The hand‐piece style (HS) mechanical torque‐limiting devices are predictable to deliver 15 Ncm torque values.
Optimal insurance contract design with government disaster relief
Authors: Hinck Sebastian 
Published: August 2023

AbstractI examine the design of optimal insurance contracts considering the possibility of government disaster relief payments. This work focuses on the impact of (risky and ambiguous) government disaster relief on the shape of optimal private insurance contracts. I demonstrate that the optimal insurance contract is a straight deductible contract in the case of a fixed probability of government relief. This result is robust to ambiguity in the probability of relief payments, even for ambiguity‐averse decision makers. If government disaster relief becomes more likely for larger losses, then the optimal insurance contract features coinsurance above a deductible. I also extend this analysis to more general stochastic dominance relationships between disaster relief and loss magnitude.
Form Shear Stress Correction in Bulk Flow Analysis of Grooved Seals Based on Effective Film Thickness
Authors: Gibbons Nathaniel , Goyne Christopher 
Published: August 2023

Abstract
Bulk flow models for grooved annular seals provide computationally efficient static and dynamic response predictions, though heavy reliance on empirical relationships often leads to undesirable levels of uncertainty. The flow complexity caused by the grooves adds difficulty to shear stress modeling for these seals. This study seeks to improve shear stress modeling for grooved seals through the identification and quantification of the additional bulk flow shear stress contributions within the groove region. Through single groove computational fluid dynamics (CFD) simulations and an effective film thickness analysis framework, the additional groove shear stress component is identified as a form shear stress (FSS) due to its clear relationship to the effective film thickness behavior. The FSS is quantified as a correction to traditional shear stress definitions. Predictive models for the FSS are developed as functions of the ratio of circumferential to axial Reynolds number and the total resultant Reynolds number. Implementation of the FSS models into a simplified bulk flow method delivers leakage predictions for three seal cases within 10% of the experimental results and qualitative agreement in predicted circumferential velocity profiles while eliminating the need for an assumed groove loss coefficient. This is the first paper to utilize an effective film thickness-based procedure to quantify and model the FSS component in grooved seal bulk flow analysis. The demonstrated predictive capability and widespread applicability of the models and approach presented in this paper provide an avenue for significant improvements in grooved seal bulk flow prediction accuracy through improved shear stress modeling.
Experimental Tribological Study on Additive Manufactured Inconel 718 Features Against the Hard Carbide Counter Bodies
Authors: Basha M. M. , Sankar M. R. 
Published: August 2023

Abstract
In past years, machining processes have been required when fabricating the complex Inconel 718 parts, and these processes cause undesired tensile residual stresses. Inconel 718 also exhibits extreme work hardening throughout the machining process. To avoid these issues, recently, Inconel 718 parts with high geometric complexity and dimensional accuracy, the laser powder bed fusion (LPBF) process, which belongs to additive manufacturing, has been extensively used. These Inconel 718 parts with LPBF processing are frequently utilized in various industries, including aerospace, automotive, pharmaceutical, and food processing, because of their high strength, biocompatibility, and corrosion resistance. Wear resistance is essential in addition to these properties for designing and crushing applications. In this paper, tribological tests were conducted on the LPBF-processed Inconel 718 parts and compared to casted Inconel 718 parts against the four types of counter bodies, namely boron carbide, silicon carbide, tungsten carbide, and titanium carbide. The studies were carried out for 30 min with a constant load of 5 N, frequency of 10 Hz, and stroke length of 1 mm. In comparison to casted samples, LPBF-processed samples showed low coefficient of friction (COF) values. The highest COF was observed on the cast Inconel 718 against the tungsten carbide counter body. The wear mechanisms were studied using scanning electron microscopy.
Reinforcing Cold-Sprayed Al Coatings With Boron Nitride Nanotubes and Micro-Boron Carbide and Their Effect on Surface Mechanical and Dry Sliding Behavior
Authors: Kulkarni Achyuth , Tauber David , Ansell Troy Y. 
Published: August 2023

Abstract
This investigation explores the reinforcement effects of both boron nitride nanotubes (BNNTs) and micro-boron carbide (μB4C) on the tribological and mechanical properties of aluminum matrix composite (MMC) cold-sprayed coatings. The synthesis process involved high-energy ball milling (HEBM) and cold spraying with helium to create four distinct Al-MMC coatings on a magnesium (AZ31) substrate. These coatings consisted of pure aluminum, a composition containing 4 vol% B4C, a composition with 4 vol% BNNTs, and a composition with 2 vol% B4C and 2 vol% BNNTs. Successful dispersion of nanoparticles within the aluminum matrix was achieved. The hardness of the coatings exhibited significant improvements compared to the pure aluminum coating. Specifically, the Al-BNNT coating showed a hardness increase of 14.1%, the Al-B4C-BNNT coating displayed a hardness increase of 20.8%, and the Al-B4C coating demonstrated the highest increase of 33.3% over the pure aluminum coating. Furthermore, the Al-B4C coating exhibited remarkable reductions in wear volume loss and wear track depth, amounting to eight and two orders of magnitude, respectively. Adhesion testing revealed that the Al-B4C-BNNT coating failed cohesively, while the pure aluminum coating failed adhesively at approximately the same force. The Al-B4C coating experienced a combination of the two failure modes at a 31.2% increase in force compared to the pure aluminum coating. Tensile testing stress versus strain curves indicated that the load was partially supported by the cold spray coating until the coating ruptured.
Analysis of Displacement-Controlled Fretting Between Crossed Parabolic Cylinders in Elasto-Plastic Contacts
Authors: Guo Tieneng , Shi Hao , Ji Ruguo , Li Bo , Wang Chenhang 
Published: August 2023

Abstract
In practice, it is difficult to avoid the axis angle deviation when some regular surfaces are in micro-sliding, such as gears and machined surfaces. In order to better investigate the micro-motion contact characteristics, a crossed paraboloidal contact model under frictional condition is proposed to simulate both tangential displacement-controlled fretting and the evolution of the energy dissipation in a load cycle. By deriving the theoretical of the normal and tangential contact course of the model, the load–displacement curves during initial loading, unloading, and reloading stage are presented. On this basis, the hysteresis curve is then obtained by integrating the closed area surrounded by load–displacement during unloading and reloading, which also means that the empirical formulation for microslip in a load cycle is constructed. This study also reveals the plastic yield phenomenon under pure normal loading and plastic shakedown behavior caused by cyclic reciprocating displacement loads. In addition, the research on the junction growth, the evolution of tangential load, and hysteresis curve with different COFs under multiple-cycle load is also carried out. The implications of involved parameters, such as friction coefficient, axis intersection angle, normal load, and so on, are discussed with respect to hysteresis curve shape and energy dissipation. The difference in hysteresis and energy dissipation curves between the paraboloidal contact model and other classic contact models is then presented. It is discovered by comparison with other models that the paraboloidal contact model presents a relatively high energy dissipation in a load cycle.
Nonlinear Energy Transfer of a Spar-Floater System Using the Inerter Pendulum Vibration Absorber
Authors: Gupta Aakash , Kiet Duong Van Tuan , Tai Wei-Che 
Published: August 2023

Abstract
The inerter pendulum vibration absorber (IPVA) is integrated between a spar and an annulus floater using a ball-screw mechanism to study its wave energy conversion potential. Hydrodynamic stiffness, added mass, and radiation damping effects on the spar-floater system are characterized using the boundary element method. It is found that a 1:2 internal resonance via a period-doubling bifurcation in the system is responsible for nonlinear energy transfer between the spar-floater system and the pendulum vibration absorber. This nonlinear energy transfer occurs when the primary harmonic solution of the system becomes unstable due to the 1:2 internal resonance phenomenon. The focus of this paper is to analyze this 1:2 internal resonance phenomenon near the first natural frequency of the system. The IPVA system when integrated with the spar-floater system is shown to outperform a linear coupling between the spar and the floater both in terms of the response amplitude operator (RAO) of the spar and one measure of the energy conversion potential of the system. Finally, experiments are performed on the IPVA system integrated with single-degree-of-freedom system (without any hydrodynamic effects) to observe the 1:2 internal resonance phenomenon and the nonlinear energy transfer between the primary mass and the pendulum vibration absorber. It is shown experimentally that the IPVA system outperforms a linear benchmark in terms of vibration suppression due to the energy transfer phenomenon.