bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Effects of Travel-resonance Method with Color Soy Source and Clear Water on Substance using Fractal Dimension Analysis of Awareness Outward-form
Authors: Jang Kyung T. , Lee Min H. , Kim Jeong L. 
Published: June 2023

Soy source has a useful effect on the human body and is the important ingredients in various foods and is an important factor of food engineer that tastes food ingredients. The forming model of the soy source was configured asymmetrical on the fractal surface and mixed with water using travel-resonance method to change a certain amount of viscosity into the shape of the surface. Travel mutational-status technology is structured the resonance status for rainbow dot pattern of the glitter awareness rate (GAR) and inequality awareness rate (IAR) on soy source travel awareness outward-form. Awareness rate condition by soy source travel awareness outward-form is structured with the circulate resonance system. Rainbow dot pattern of the happen mutational-status is to check up to structure of soy source travel value with travel layer location by the circulate-down structure. Concept of awareness rate is check up the reference of glitter rate and inequality rate for mutational-status signal by soy source travel resonance outward-form. Happen mutational-status of the GAR-IAR is presented position value of maximum-minimum on soy source travel-resonance outward-form. Far mutational-status of the Tr-aof-FA-?MAX-MIN presented the travel value with 14.67±7.32 units. Convenient mutational-status of Tr-aof-CO-?MAX-MIN presented the travel value with 4.48±0.46 units. Flank mutational-status of the Tr-aof-FL-?MAX-MIN presented the travel value with 1.29±0.32 units. Vicinage mutational-status of the Tr-aof-VI-?MAX-MIN presented the travel value with 0.23±0.07 units. Circulate resonance will be to inquire into at the ability of soy source travel-resonance outward-form for the restrain degree awareness rate on the GAR-IAR that is stick-out the happen glitter and inequality outward-form by the awareness rate system. Awareness outward-form LED will be to inquire into of outward-form by the inequality signal and to figure a travel data of circulate resonance rate by the circulate awareness system. due to the effect of image resolution.
O trabalho: sua centralidade no mundo contemporâneo
Authors: Melo Neto José Francisco De 
Published: June 2023

<p>Este texto insere-se na discussão atual sobre a problemática do trabalho. Procura mostrar que existe, ainda, uma mistura teórica ao identificar-se trabalho com emprego, quando se esquece de que trabalho é uma relação filosófica do humano com a natureza, enquanto que emprego é uma mera relação funcional na vida das pessoas. O trabalho, sendo uma relação humana com a natureza, é caracterizado, dialeticamente, como expressão de humanização da natureza enquanto que, também, se constitui como um processo de naturalização do humano. Finalmente, apresenta uma perspectiva teórica do trabalho como uma questão que se mantém no centro do debate paradigmático, nos dias de hoje.</p>
Sensory dimensions derived from competitive and creative perceptual interactions between fruity ethyl esters and woody odorants in wine-like models
Authors: De la Fuente Blanco Arancha , Sáenz-Navajas María-Pilar , Ballester Jordi , Franco-Luesma Ernesto , Valentin Dominique , Ferreira Vicente 
Published: June 2023

The present study analyses the sensory effects associated with the interactions between different woody aroma compositions and a simple fruity ester vector in red wines. The semi-synthetic wine models contained a fixed aroma composition, the dearomatised non-volatile fraction of red wine and 21 different combinations of ethyl 2-methylbutyrate (fruity vector) plus 1 out of 3 woody aroma compositions (woody vectors) at 3 possible levels of concentration each. Woody vectors imitated a highly toasted American oak (HAO—elevated levels of whiskylactones and furaneol), a highly toasted French oak (HFO—low levels of whiskylactone and vanillin levels, high levels of eugenol and guaiacol) and a medium toasted French oak (MFO—low levels of whiskylactones, eugenol, guaiacol and furaneol and high levels of vanilla). Models were sensorily assessed by a sorting task and by descriptive analysis. The increase in woody notes causes a concomitant decrease in fruity notes by a competitive perceptual interaction. HAO models are richest in coconut and woody notes and poorest in fruity notes, while HFO models keep strawberry and apple notes. At certain specific fruity-woody vector ratios, particularly in the MFO model, blackcurrant notes emerge, which can be considered a creative perceptual interaction.
EVALUATION OF THE EFFECT OF SPATHODEA CAMPANULATA FLOWER BUD EXUDATE ON CATARACTOGENESIS IN RAT LENSES
Authors: Adio Gbemisola I , Faluyi J. O. , Osoniyi Omolaja 
Published: June 2023

Background: The flower bud exudates of Spathodea campanulata is commonly used as a local eye drop in Nigeria and is anecdotally claimed to improve vision. This study evaluated the anti-cataract activity of Spathodea campanulata (SPCM) flower bud exudates against cataractogenesis using rat lenses. This was done with a view to providing empirical scientific support for the use of the exudates from SPCM in the treatment and management of certain eye disorders.
Materials and Methods: Fifty (50) rat lenses were used in this study, i.e. five groups of ten (10) lenses per group. Lenses were incubated in artificial aqueous humor (Normal control) with simultaneous incubation in 30 mM galactose (Untreated cataract). Co-incubation with captopril (Captopril treated cataract); 0.1 mg/ml of the exudate (Exudate treated cataract - Low dose) and 0.2 mg/ml of exudate (Exudate treated cataract- High dose) constituted the study groups. After 72 hr of incubation, lenses were observed for cataract and the preventive potential of the exudate against cataractogenesis was evaluated through the determination of the levels of anti-oxidant parameters such as total protein (TP), glutathione (GSH), malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and catalase (CAT) were evaluated in the lens homogenates.
Results: Photographic evaluation of the lenses showed the development of cataract in the untreated cataract group while opacification was retarded in higher dose exudate-treated and captopril treated lenses. Significant decrease in the levels of GSH and total protein, reduction in SOD and CAT activities as well as increase in MDA content were observed in cataractous lenses when compared with the normal control. SPCM displayed a dose-related anti-cataract activity. Captopril showed comparable anti-cataract potential to (0.2 mg/ml) SPCM. GSH, SOD and CAT activity in captopril treated cataract lenses increased to 75.55%, 64.08% and 72.45% of the normal control values respectively. In (0.2 mg/ml) exudate treated cataract lenses; GSH, SOD and CAT activity increased to 57.7%, 76.69% and 80.61% respectively.
Conclusion: The study concluded that exudate of SPCM elicited its anti-cataract potential through its anti-oxidant activities.
Solving Coupled Differential Equation Groups Using PINO-CDE
Authors: Ding Wenhao , He Qing , Tong Hanghang , Wang Ping 
Published: June 2023

Abstract

As a fundamental mathmatical tool in many engineering disciplines, coupled differential equation groups are being widely used to model complex structures containing multiple physical quantities. Engineers constantly adjust structural parameters at the design stage, which requires a highly efficient solver. The rise of deep learning technologies has offered new perspectives on this task. Unfortunately, existing black-box models suffer from poor accuracy and robustness, while the advanced methodologies of single-output operator regression cannot deal with multiple quantities simultaneously. To address these challenges, we propose PINO-CDE, a deep learning framework for solving coupled differential equation groups (CDEs) along with an equation normalization algorithm for performance enhancing. Based on the theory of physics-informed neural operator (PINO), PINO-CDE uses a single network for all quantities in a CDEs, instead of training dozens, or even hundreds of networks as in the existing literature. We demonstrate the flexibility and feasibility of PINO-CDE for one toy example and two engineering applications: vehicle-track coupled dynamics (VTCD) and reliability assessment for a four-storey building (uncertainty propagation). The performance of VTCD indicates that PINO-CDE outperforms existing software and deep learning-based methods in terms of efficiency and precision, respectively. For the uncertainty propagation task, PINO-CDE provides higher-resolution results in less than a quarter of the time incurred when using the probability density evolution method (PDEM). This framework integrates engineering dynamics and deep learning technologies and may reveal a new concept for CDEs solving and uncertainty propagation.
Analysis and Challenges in Detecting the Fake Reviews of Products using Naïve Bayes and Random Forest Techniques
Authors: Sajid Tanveer , Jamshed Wasim , Goyal Navin Kumar , Keswani Bright , Altamirano Gilder Cieza , Goyal Dinesh , Keswani Poonam 
Published: June 2023

Abstract
In today’s world, fake review identification and prediction is an importantarea of sentiment analysis of the E-commerce industry. The automatic fake review categorizersidentify and categorize a variety of duplicate, spam, fake and untrustworthy reviews using machine learning techniques. This paper studies various recent existing fake review detection methods using NB and RF classifiers for the Yelp and Flipkart datasets. It provides a detailed study on various fake review predictors and compares their basic and performance-based specifications. It highlights the challenges, threats, and gaps of these existing works. Further, it graphically shows the discrimination for the specifications of year-wise evolution, classifier usage, and dataset usage.
Glucocorticoid reduction induced chorea in pediatric-onset systemic lupus erythematosus patient
Authors: Xu Yanqiu , Wang Miao , Zhang Ying 
Published: June 2023

Abstract
Background
Pediatric-onset systemic lupus erythematosus (SLE) is typically more severe than the adult-onset SLE, with a higher incidence of nervous system involvement. Chorea is a relatively rare neurological complication reported in approximately 1.2%–2% of SLE patients. Especially it is even rarer in chorea induced by glucocorticoid reduction. Herein, we report a case of a girl with SLE, who developed chorea in the process of glucocorticoid therapy reduction.
Case presentation
We describe a 14-year-old girl who was diagnosed with SLE. She was treated with methylprednisolone and rituximab, while the girl’s symptoms improved. On the second day after methylprednisolone was reduced according to the treatment guidelines, the patient developed chorea. Her condition improved after adjusting her glucocorticoid regimen.
Conclusion
The emergence of chorea can be induced by glucocorticoid reduction in patients with pediatric-onset SLE. This case is a reminder to pay extra attention to the chorea of SLE patients during glucocorticoid reduction.
Effects of adding low-dose esketamine to sufentanil and propofol sedation during cervical conization: a prospective, single-center, randomized controlled trial
Authors: Si Jiguo , Tan Mingtao , Li Xiaomin , Wang Yuqi , Feng Nianhai , Cui Min 
Published: June 2023

Abstract
Background
Cervical conization is a brief but painful procedure that can be performed under deep sedation with propofol and opioids. However, this sedation approach comes with a high risk of sedation-related adverse events (SRAEs). Esketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, has the property of less cardiorespiratory depression than opioids. The aim of this study was to assess the efficacy and safety of adding a low-dose esketamine to propofol and sufentanil sedation as an opioid-reduced regimen.
Methods
122 consecutive patients with ASA Ⅰ-Ⅲ, body mass index < 30, STOP-BANG score < 3 who underwent cervical conization were enrolled and randomly divided into group S and group ES. Using a closed-loop target-controlled infusion (TCI) pump with target bispectral index (BIS) value of 60 ± 5, patients in group S were sedated with 0.2µg/kg sufentanil and propofol, while patients in group ES were sedated with 0.15mg/kg esketamine, 0.1µg/kg sufentanil and propofol. The primary endpoint was the composite incidence of SRAEs, while the second endpoints included effectiveness of sedation, awakening time, psychotomimetic side effects, postoperative pain, postoperative nausea and vomiting, and patient and gynecologist satisfaction.
Results
Data of 120 patients were analyzed. The incidence of composite SRAEs was significantly higher in group S compared to group ES (85.0% vs 56.7%, P < 0.05). Furthermore, the severity of SRAEs was higher in group S compared to group ES (P < 0.001). There were no significant differences in the success of sedation, awakening time, psychotomimetic side effects, postoperative nausea and vomiting, postoperative pain, and patient and gynecologist satisfaction between the two groups.
Conclusion
Adding a low-dose esketamine to propofol and sufentanil sedation reduces the incidence and severity of SRAEs in patients undergoing cervical conization, with equal sedation efficacy, recovery quality, and no additional psychomimetic side effects.
Trial registration
ChiCTR2000040457, 28/11/2020
Genetic and Multi-omic Risk Assessment of Alzheimer’s Disease Implicates Core Associated Biological Domains
Authors: Cary Greg A , Wiley Jesse C , Gockley Jake , Keegan Stephen , Ganesh Sruthi , Heath Laura , III Robert R Butler , Mangravite Lara M , Logsdon Ben A , Longo Frank M , Levey Allan I , Greenwood Anna K , Carter Gregory W 
Published: June 2023

Abstract

Background: Alzheimer’s disease (AD) is the predominant dementia globally, with heterogeneous presentation and penetrance of clinical symptoms, variable presence of mixed pathologies, potential disease subtypes, and numerous associated endophenotypes. However, there is no methodology to objectively rank endophenotypes for disease risk, nor to enumerate the genes associated with each endophenotype at a genome scale. Consequently, therapeutic development is challenged by the uncertainty of which endophenotypic areas, and specific subordinate targets, to prioritize for further translational research.
Methods: Here we report the development of an informatic pipeline that ranks genes for AD risk genome wide and organizes them into disease associated endophenotypes--which we call AD biological domains. The AD risk ranking draws from genetic association studies, predicted variant impact, and linkage with dementia associated phenotypes to create a genetic risk score. This is paired with a multi-omic risk score utilizing extensive sets of both transcriptomic and proteomic studies to identify systems level changes in expression associated with AD. These two elements combined constitute our target risk score (TRS) that ranks AD risk genome wide. The ranked genes are organized into endophenotypic space through the development of 19 biological domains associated with AD in the described genetics and genomics studies and accompanying literature. The biological domains are constructed from exhaustive gene ontology (GO) term compilations, allowing automated assignment of genes into objectively defined disease-associated biology. This rank and organize approach, performed genome-wide, allows the characterization of aggregations of AD risk across biological domains.
Results: The top AD-risk associated biological domains are Synapse, Immune Response, Lipid Metabolism, Mitochondrial Metabolism, Structural Stabilization, and Proteostasis, with slightly lower levels of risk enrichment present within the other 13 biological domains. Synapse and Mitochondrial Metabolism are the most down-regulated biological domains, with mitochondrial function being the most enriched, while Immune Response is the most up-regulated biological domain.
Conclusions: The TRS ranked genes which are organized into the biological domains provides an objective methodology that can be automated into workflows to localize risk within specific biological endophenotypes, and drill down into the most significantly associated sets of GO-terms and annotated genes for potential therapeutic targets.
How to strengthen societal impact of research and innovation? Lessons learned from assessing participatory knowledge infrastructures funded by the Netherlands Organization for Health Research and Development
Authors: Oortwijn Wija , Reijmerink Wendy , Bussemaker Jet 
Published: June 2023

Abstract
Background
Scientific research and innovation can generate societal impact via different pathways. Productive interactions, such as collaboration between researchers and relevant stakeholders, play an important role and have increasingly gained interest of health funders around the globe. What works, how and why in research partnerships to generate societal impact in terms of knowledge utilisation is still not well-known. To explore these issues, the Netherlands Organization for Health Research and Development (ZonMw) initiated a research-on-research study with a focus on participatory knowledge infrastructures (PKIs) that they fund in the field of public health and healthcare. PKIs are sustainable infrastructures in which knowledge production, dissemination and utilisation takes place via committed collaboration between researchers and stakeholders from policy, practice and/or education. Examples are learning networks, academic collaborative centres, care networks and living labs. The aim of the study was twofold: to gain insights in what constitutes effective collaboration in PKIs; and to learn and improve the research governance, particularly of ZonMw as part of their dissemination and implementation activities.
Methods
During 2020-2022, we conducted a literature review on long-term research partnerships, analysed available documentation of twenty ZonMw-funded PKIs, surveyed participants of the 2021 European Implementation Event, interviewed steering committee members, organized a Group Decision Room with lecturers, and validated the findings with key experts.
Results
We identified eight mechanisms (‘how and why’) that are conditional for effective collaboration in PKIs: transdisciplinary collaboration; defining a shared ambition; doing justice to everyone's interests; investing in personal relationships; a professional organisation or structure; a meaningful collaborative process; mutual trust, sufficient time for and continuity of collaboration. Several factors (‘what’) may hinder (e.g., lack of ownership or structural funding) or facilitate (e.g., stakeholder commitment, embeddedness in an organisation or policy) effective collaboration in research partnerships.
Conclusion
To use the study results in policy, practice, education, and/or (further) research, cultural and behavioural change of all stakeholders is needed. To facilitate this, we provide recommendations for funding organisations, particularly ZonMw and its partners within the relevant knowledge ecosystem. It is meant as a roadmap towards the realisation and demonstration of societal impact of (health) research and innovation in the upcoming years.
Functional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis
Authors: zhong jie , Wang Chaodong , zhang dan , Yao Xiaoli , Zhao Quanzhen , Huang Xusheng , Lin Feng , Xue Chun , Wang Yaqing , He Ruojie , Li Xu-Ying , Li Qibin , Wang Mingbang , Zhao Shaoli , Afridi Shabbir , Zhou Wenhao , Wang Zhanjun , Xu Yanming , Xu Zhiheng 
Published: June 2023

Abstract
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify additional genetic contributors to ALS, we analyzed exome sequences in a large cohort of Chinese ALS patients. We found a homozygous variant (p.L700P) in PCDHA9 in three unrelated patients but not in publicly available genomic databases. We generated Pcdhα9 mutant mice harboring either orthologous point mutation or deletion mutation. These mice developed progressive spinal motor loss, muscle atrophy, and structural/functional abnormalities of the neuromuscular junction, leading to paralysis and early lethality. Importantly, TDP-43 pathology was observed in the ventral spinal motor neurons of aged point mutant mice. Mechanistically, we demonstrate that Pcdha9 mutation causes aberrant activation of FAK and PYK2 in the aged spinal cord. Furthermore, we uncovered a novel PCDHA9-interacting protein, Na+/K+ ATPase-α1, and its dramatically reduced expression in mutant motor neurons. Accordingly, single nucleus multi-omics analysis revealed disturbed networks or signaling involved in cell/cell-cell adhesion, ion transport, synapse organization, and neuronal survival in aged mutant mice. Together, our results present PCDHA9 as a new candidate ALS gene and provide insights into its pathogenesis.
Species Distribution Modeling of Variable Tawny Rajah (Charaxes bernardus hierax) in some unusual habitats of West Bengal, India: implications for conservation
Authors: Mukherjeeq Subha Shankar , Purohit Saurabh , Bag Soumyadip , Aditya Gautam , Hossain Asif 
Published: June 2023

Abstract

Lepidopteran species serve as one of the most important pollinators in ecosystem and this species also coevolved with their nectaring plants. They regarded as one of the good indicators of ecosystem health due to their high sensitivity to the changes in environmental variables. There are numerous butterfly and moth species are found in India whose possible distribution in the geographic areas yet to be known. In our present study we try to find out the predicted distribution area of Variable Tawny Rajah (Charaxes bernardus hierax) in West Bengal by the use MaxEnt 3.4.4 program. It was observed that northern part of West Bengal consists of greater areas that contain suitable environmental conditions (maximum and moderate) than southern part of West Bengal. The regions with > 304 mm and > 105 mm precipitation (bio 13 and bio 15) are considered to suitable for sustaining this species. This type of study may helps to provide an idea about predicted distribution of Charaxes bernardus hierax in West Bengal and selection of conservation strategies for this butterfly species in particular geographical region.