bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embodying Place
Authors: NESVADERANI NAT 
Published: May 2023

AbstractThis article explores the implications of the Making Home Project, a participatory audio‐visual media project with migrant and refugee youth in Iran. This project does not picture the faces of youth as they express caring relationships and attachments to the people and places within the migrant neighborhoods where they reside—places locally characterized as poor, dangerous, and transient. I examine the audio, the visual and the off‐screen encounters of this participatory production to demonstrate how media outcomes are shaped by Afghan youth's differently situated refugee experiences in Iran. Ultimately, I argue that space and place are actualized through the embodied act of youth expressing and producing audio‐visual media about their homeplace.
HUMAN UNIQUENESS FROM A BIOLOGICAL POINT OF VIEW
Authors: Reich David 
Published: May 2023

AbstractThis article seeks to provide some genetic perspectives on the question “Just How Special Are Humans—Really?” It begins with an introduction to how genetic variation can provide information about the past. It continues by discussing two ways in which genetic analyses has, on multiple occasions, shown that humans are less unique than we thought we are. We have a cognitive bias to toward thinking we are special. Our species has colonized an ecological niche not exploited by any other species on our earth, but how much of our adaptation to that niche is cultural rather than genetic?
Heights on curves and limits of Hodge structures
Authors: Bloch Spencer , de Jong Robin , Sertöz Emre Can 
Published: May 2023

AbstractWe exhibit a precise connection between Néron–Tate heights on smooth curves and biextension heights of limit mixed Hodge structures associated to smoothing deformations of singular quotient curves. Our approach suggests a new way to compute Beilinson–Bloch heights in higher dimensions.
Exploring the role of TRPM4 in calcium‐dependent triggered activity and cardiac arrhythmias
Authors: Pironet Andy , Vandewiele Frone , Vennekens Rudi 
Published: May 2023

AbstractCardiac arrhythmias pose a major threat to a patient's health, yet prove to be often difficult to predict, prevent and treat. A key mechanism in the occurrence of arrhythmias is disturbed Ca2+ homeostasis in cardiac muscle cells. As a Ca2+‐activated non‐selective cation channel, TRPM4 has been linked to Ca2+‐induced arrhythmias, potentially contributing to translating an increase in intracellular Ca2+ concentration into membrane depolarisation and an increase in cellular excitability. Indeed, evidence from genetically modified mice, analysis of mutations in human patients and the identification of a TRPM4 blocking compound that can be applied in vivo further underscore this hypothesis. Here, we provide an overview of these data in the context of our current understanding of Ca2+‐dependent arrhythmias.
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Low-Cost and Rapid Shaping of Nitinol for Medical Device Prototyping
Authors: Yip Mighten C. , Alaie Seyedhamidreza , Romito Eva A. , Doshi Tejas , Amiri Moghadam Amir Ali , Mosadegh Bobak , Dunham Simon 
Published: May 2023

Abstract
This paper describes the methodology for rapid prototyping of nitinol structures by heat setting. Nitinol is a shape memory alloy commonly used in implantable medical devices. The proposed technique, based on 3D printing, can be used to effectively iterate multiple nitinol designs for different types of medical devices. We describe a rapid and low-cost process of ceramic replica molding of standard 3D printed parts to create high-temperature resistant fixtures, suitable for heat setting of nitinol. The technique represents a low cost (&lt;$20 materials per fixture) and rapid (as quickly as 16 h for a volume less than 1.25 × 105 mm3) method for shaping nitinol, a technique that typically is costly, labor intensive, and requires specialized equipment. Our method satisfies a need for cost-effective, rapid prototyping of nitinol for implantable medical devices, and we show an example set of shaped nitinol wires, clips, and stents. This method is straightforward and can be easily applied by researchers to rapidly iterate medical device designs.
Early identification of persistent somatic symptoms in primary care: data-driven and theory-driven predictive modelling based on electronic medical records of Dutch general practices
Authors: Kitselaar Willeke M , Büchner Frederike L , van der Vaart Rosalie , Sutch Stephen P , Bennis Frank C , Evers Andrea WM , Numans Mattijs E 
Published: May 2023

ObjectiveThe present study aimed to early identify patients with persistent somatic symptoms (PSS) in primary care by exploring routine care data-based approaches.Design/settingA cohort study based on routine primary care data from 76 general practices in the Netherlands was executed for predictive modelling.ParticipantsInclusion of 94 440 adult patients was based on: at least 7-year general practice enrolment, having more than one symptom/disease registration and >10 consultations.MethodsCases were selected based on the first PSS registration in 2017–2018. Candidate predictors were selected 2–5 years prior to PSS and categorised into data-driven approaches: symptoms/diseases, medications, referrals, sequential patterns and changing lab results; and theory-driven approaches: constructed factors based on literature and terminology in free text. Of these, 12 candidate predictor categories were formed and used to develop prediction models by cross-validated least absolute shrinkage and selection operator regression on 80% of the dataset. Derived models were internally validated on the remaining 20% of the dataset.ResultsAll models had comparable predictive values (area under the receiver operating characteristic curves=0.70 to 0.72). Predictors are related to genital complaints, specific symptoms (eg, digestive, fatigue and mood), healthcare utilisation, and number of complaints. Most fruitful predictor categories are literature-based and medications. Predictors often had overlapping constructs, such as digestive symptoms (symptom/disease codes) and drugs for anti-constipation (medication codes), indicating that registration is inconsistent between general practitioners (GPs).ConclusionsThe findings indicate low to moderate diagnostic accuracy for early identification of PSS based on routine primary care data. Nonetheless, simple clinical decision rules based on structured symptom/disease or medication codes could possibly be an efficient way to support GPs in identifying patients at risk of PSS. A full data-based prediction currently appears to be hampered by inconsistent and missing registrations. Future research on predictive modelling of PSS using routine care data should focus on data enrichment or free-text mining to overcome inconsistent registrations and improve predictive accuracy.
Costs, consequences and value for money in non-medical prescribing: a scoping review
Authors: Babashahi Saeideh , Carey Nicola , Jani Yogini , Hart Kath , Hounsome Natalia 
Published: May 2023

ObjectivesNon-medical prescribing (NMP) is a key feature of the UK healthcare system that refers to the legal prescribing rights granted to nurses, pharmacists and other non-medical healthcare professionals who have completed an approved training programme. NMP is deemed to facilitate better patient care and timely access to medicine. The aim of this scoping review is to identify, synthesise and report the evidence on the costs, consequences and value for money of NMP provided by non-medical healthcare professionals.DesignScoping reviewData sourcesMEDLINE, Cochrane Library, Scopus, PubMed, ISI Web of Science and Google Scholar were systematically searched from 1999 to 2021.Eligibility criteriaPeer-reviewed and grey literature written in English were included. The research was limited to original studies evaluating economic values only or both consequences and costs of NMP.Data extraction and synthesisThe identified studies were screened independently by two reviewers for final inclusion. The results were reported in tabular form and descriptively.ResultsA total of 420 records were identified. Of these, nine studies evaluating and comparing NMP with patient group discussions, general practitioner-led usual care or services provided by non-prescribing colleagues were included. All studies evaluated the costs and economic values of prescribing services by non-medical prescribers, and eight assessed patient, health or clinical outcomes. Three studies showed pharmacist prescribing was superior in all outcomes and cost saving at a large scale. Others reported similar results in most health and patient outcomes across other non-medical prescribers and control groups. NMP was deemed resource intensive for both providers and other groups of non-medical prescribers (eg, nurses, physiotherapists, podiatrists).ConclusionsThe review demonstrated the need for quality evidence from more rigorous methodological studies examining all relevant costs and consequences to show value for money in NMP and inform the commissioning of NMP for different groups of healthcare professionals.
Faecal microbiota transplantation to prevent complications after allogeneic stem cell transplantation for haematological malignancies: a study protocol for a randomised controlled phase-II trial (the FMT-allo study)
Authors: Dougé Aurore , Ravinet Aurélie , Corriger Alexandrine , Cabrespine Aurélie , Wasiak Mathieu , Pereira Bruno , Sokol Harry , Nguyen Stéphanie , Bay Jacques-Olivier 
Published: May 2023

IntroductionAllogeneic haematopoietic stem-cell transplantation (allo-HSCT) is a major treatment for many haematological malignancies. The procedure has a good success rate but high transplant-related toxicity (TRM). TRM is mostly related to graft-versus-host disease (GvHD) and infectious complications. Alterations of the intestinal microbiota plays a major role in the development of allo-HSCT complications. The gut microbiota could be restored by faecal microbiota transplantation (FMT). However, there are no published randomised studies assessing the efficacy of FMT for GvHD prophylaxis.Methods and analysisThis prospective, open-label, multi-centre, parallel-group, randomised phase-II clinical trial has been designed to assess the effect of FMT on toxicity in patients treated with myeloablative allo-HSCT for haematological malignancy. Based on Fleming’s single-stage sample size estimation procedure, the design plans to include 60 male and female patients aged 18 or over per arm, to be randomly assigned to two groups, one with and one without (control group) FMT. The primary endpoint is GvHD-free relapse-free survival rate at 1 year after allo-HSCT. Secondary endpoints are outcome measures of the impact of FMT on allo-HSCT-related morbidity and mortality (overall survival and progression-free survival at 1 and 2 years, haematological parameters, infectious complications, tolerance and safety of FMT). The primary endpoint will be evaluated according to assumptions of the single-stage Fleming design, compared between groups by a log-rank test and further investigated in a multivariate marginal structural Cox model taking into account centre effect. The proportional-hazard hypothesis will be verified using Schoenfeld’s test and by plotting residuals.Ethics and disseminationThe local institutional review board (CPP Sud-Est II, France) issued approval on 27 January 2021. The French national authorities issued approval on 15 April 2021. The outcome of the study will be disseminated via peer-reviewed publications and at congresses.Trial registration numberNCT04935684.
Examining spousal and family support as predictors of long-term weight loss and remission of type 2 diabetes following bariatric surgery in Singapore: a retrospective cohort study
Authors: Tan Edina Yi-Qin , Lee Phong Ching , Tham Kwang Wei , Ganguly Sonali , Lim Chin Hong , Liu Jean C J 
Published: May 2023

ObjectivesPostoperative outcomes vary considerably across bariatric patients and may be related to psychosocial factors. In this study, we examined whether a patient’s family support predicts postsurgical weight loss and the remission of type 2 diabetes mellitus (T2DM).DesignRetrospective cohort study in Singapore.SettingParticipants were recruited from a public hospital in Singapore.ParticipantsBetween 2008 and 2018, 359 patients completed a presurgical questionnaire before undergoing gastric bypass or sleeve gastrectomy.Outcome measuresAs part of the questionnaire, patients described their family support in terms of structure (marital status, number of family members in the household) and function (marriage satisfaction, family emotional support, family practical support). Linear mixed-effects and Cox proportional-hazard models were used to examine whether these family support variables predicted percent total weight loss or T2DM remission up to 5 years postsurgery. T2DM remission was defined as glycated haemoglobin (HbA1c) <6.0% without medications.ResultsParticipants had a mean preoperative body mass index of 42.6±7.7 kg/m2and HbA1c (%) of 6.82±1.67. Marital satisfaction was found to be a significant predictor of postsurgical weight trajectories. Namely, patients who reported higher marital satisfaction were more likely to sustain weight loss than patients who reported lower marital satisfaction (β=0.92, SE=0.37, p=0.02). Family support did not significantly predict T2DM remission.ConclusionsGiven the link between marital support and long-term weight outcomes, providers could consider asking patients about their spousal relationships during presurgical counselling.Trial registration numberNCT04303611.
Validation of a rapid SARS-CoV-2 antibody test in general practice
Authors: Domen Julie , Verbakel Jan Yvan Jos , Adriaenssens Niels , Scholtes Beatrice , Peeters Bart , Bruyndonckx Robin , De Sutter An , Heytens Stefan , Van den Bruel Ann , Desombere Isabelle , Van Damme Pierre , Goossens Herman , Buret Laetitia , Duysburgh Els , Coenen Samuel 
Published: May 2023

ObjectivesTo validate a rapid serological test (RST) for SARS-CoV-2 antibodies used in seroprevalence studies in healthcare providers, including primary healthcare providers (PHCPs) in Belgium.DesignA phase III validation study of the RST (OrientGene) within a prospective cohort study.SettingPrimary care in Belgium.ParticipantsAny general practitioner (GP) working in primary care in Belgium and any other PHCP from the same GP practice who physically manages patients were eligible in the seroprevalence study. For the validation study, all participants who tested positive (376) on the RST at the first testing timepoint (T1) and a random sample of those who tested negative (790) and unclear (24) were included.InterventionAt T2, 4 weeks later, PHCPs performed the RST with fingerprick blood (index test) immediately after providing a serum sample to be analysed for the presence of SARS-CoV-2 immunoglobulin G antibodies using a two-out-of-three assay (reference test).Primary and secondary outcome measuresThe RST accuracy was estimated using inverse probability weighting to correct for missing reference test data, and considering unclear RST results as negative for the sensitivity and positive for the specificity. Using these conservative estimates, the true seroprevalence was estimated both for T2 and RST-based prevalence values found in a cohort study with PHCPs in Belgium.Results1073 paired tests (403 positive on the reference test) were included. A sensitivity of 73% (a specificity of 92%) was found considering unclear RST results as negative (positive). For an RST-based prevalence at T1 (13.9), T2 (24.9) and T7 (70.21), the true prevalence was estimated to be 9.1%, 25.9% and 95.7%, respectively.ConclusionThe RST sensitivity (73%) and specificity (92%) make an RST-based seroprevalence below (above) 23% overestimate (underestimate) the true seroprevalence.Trial registration numberNCT04779424.
Exploration of the unmet needs of patients diagnosed with idiopathic pulmonary fibrosis: a scoping review protocol
Authors: Bramhill Carita , Langan Donna , Mulryan Helen , Eustace-Cook Jessica , Russell Anne-Marie , Brady Anne-Marie 
Published: May 2023

IntroductionInterstitial lung diseases consist of a range of lung disorders, the most prevalent being idiopathic pulmonary fibrosis (IPF). IPF is a chronic, progressive disease, resulting in loss of lung function and potentially significant impacts on quality of life. There is an increasing need to address unmet needs in this population as there is evidence that unmet needs may impact quality of life and health outcomes. The key objective of this scoping review is to define the unmet needs of patients living with a diagnosis of IPF and to identify gaps in the literature relating to unmet needs. Findings will inform the development of services and the introduction of patient-centred clinical care guidelines for IPF.Methods and analysisThis scoping review is guided by the methodological framework for conducting scoping reviews developed by the Joanna Briggs Institute. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist is used for guidance. The following databases will be searched: CINAHL, MEDLINE, PsycINFO, Web of Science, Embase and ASSIA and include a comprehensive grey literature search. The review will report on adult patients >18 with a diagnosis of IPF or pulmonary fibrosis and be limited to publications from 2011 onwards, with no language restrictions applied. Two independent reviewers will screen articles in consecutive stages for relevance against the inclusion and exclusion criteria. Data will be extracted using a predefined data extraction form and analysed using descriptive and thematic analysis. Findings will be presented in tabular form, coupled with a narrative summary of the evidence.Ethics and disseminationEthics approval is not required for this scoping review protocol. We will disseminate our findings using traditional approaches that include open access peer-reviewed publications and scientific presentations.
Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitudinal Study
Authors: Liu Peijia , Liang Ying , Cui Sini , Hu Kaiyuan , Lin Liu , Shao Xinning , Lei Ming 
Published: May 2023

ObjectiveWhether uric acid (UA) has an effect on renal function remains controversial. We aimed to investigate the association between serum UA with the decline in estimated glomerular filtration rate (eGFR) in middle-aged and elderly populations in the China Health and Retirement Longitudinal Study (CHARLS).DesignLongitudinal cohort study.SettingThis was a second analysis of a public dataset (CHARLS).ParticipantsIn this study, 4538 middle-aged and elderly individuals were screened after removing individuals younger than 45 years old, with kidney disease, malignant tumour and missing values.Outcome measuresBlood tests were performed both in 2011 and 2015. Decline in eGFR was defined as an eGFR decrease of more than 25% or deterioration of the eGFR stage during the 4-year follow-up period. Logistic models corrected for multiple covariables were used to analyse the association of UA with the decline in eGFR.ResultsThe median (IQR) concentrations of serum UA grouped by quartiles were 3.1 (0.6), 3.9 (0.3), 4.6 (0.4) and 5.7 (1.0) mg/dL, respectively. After multivariable adjustment, the OR of the decline in eGFR was higher for quartile 2 (3.5–<4.2 mg/dL: OR 1.44; 95% CI 1.07 to 1.64; p<0.01), quartile 3 (4.2–<5.0 mg/dL: OR 1.72; 95% CI 1.36 to 2.18; p<0.001) and quartile 4 (≥5.0 mg/dL: OR 2.04; 95% CI 1.58 to 2.63; p<0.001) when compared with quartile 1 (<3.5 mg/dL), and the p value for the trend was <0.001.ConclusionsOver a 4-year follow-up period, we found that elevated UA was associated with a decline in eGFR in the middle-aged and elderly individuals with normal renal function.
The VEBAS score: a practical scoring system for intracranial dural arteriovenous fistula obliteration
Authors: Becerril-Gaitan Andrea , Ding Dale , Ironside Natasha , Buell Thomas J , Kansagra Akash P , Lanzino Giuseppe , Brinjikji Waleed , Kim Louis , Levitt Michael R , Abecassis Isaac Josh , Bulters Diederik , Durnford Andrew , Fox W Christopher , Blackburn Spiros , Chen Peng Roc , Polifka Adam J , Laurent Dimitri , Gross Bradley , Hayakawa Minako , Derdeyn Colin , Amin-Hanjani Sepideh , Alaraj Ali , van Dijk J Marc C , Potgieser Adriaan R E , Starke Robert M , Peterson Eric C , Satomi Junichiro , Tada Yoshiteru , Abla Adib A , Winkler Ethan A , Du Rose , Lai Pui Man Rosalind , Zipfel Gregory J , Chen Ching-Jen , Sheehan Jason P 
Published: May 2023

Background
Tools predicting intracranial dural arteriovenous fistulas (dAVFs) treatment outcomes remain scarce. This study aimed to use a multicenter database comprising more than 1000 dAVFs to develop a practical scoring system that predicts treatment outcomes.

Methods
Patients with angiographically confirmed dAVFs who underwent treatment within the Consortium for Dural Arteriovenous Fistula Outcomes Research-participating institutions were retrospectively reviewed. A subset comprising 80% of patients was randomly selected as training dataset, and the remaining 20% was used for validation. Univariable predictors of complete dAVF obliteration were entered into a stepwise multivariable regression model. The components of the proposed score (VEBAS) were weighted based on their ORs. Model performance was assessed using receiver operating curves (ROC) and areas under the ROC.

Results
A total of 880 dAVF patients were included. Venous stenosis (presence vs absence), elderly age (<75 vs ≥75 years), Borden classification (I vs II-III), arterial feeders (single vs multiple), and past cranial surgery (presence vs absence) were independent predictors of obliteration and used to derive the VEBAS score. A significant increase in the likelihood of complete obliteration (OR=1.37 (1.27–1.48)) with each additional point in the overall patient score (range 0–12) was demonstrated. Within the validation dataset, the predicted probability of complete dAVF obliteration increased from 0% with a 0–3 score to 72–89% for patients scoring ≥8.

Conclusion
The VEBAS score is a practical grading system that can guide patient counseling when considering dAVF intervention by predicting the likelihood of treatment success, with higher scores portending a greater likelihood of complete obliteration.