bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naringenin improves ovarian health by reducing the serum androgen and eliminating follicular cysts in letrozole‐induced polycystic ovary syndrome in the Sprague Dawley rats
Authors: Rashid Rumaisa , Tripathi Rupal , Singh Akanksha , Sarkar Sudarsan , Kawale Ajaykumar , Bader G. N. , Gupta Satish , Gupta Rakesh Kumar , Jha Rajesh Kumar 
Published: May 2023

AbstractPolycystic ovary syndrome (PCOS) is most common in women of reproductive age, giving rise to androgen excess and anovulation, leading to infertility and non‐reproductive complications. We explored the ameliorating effect of naringenin in PCOS using the Sprague Dawley (SD) rat model and human granulosa cells. Letrozole‐induced PCOS rats were given either naringenin (50 mg/kg/day) alone or in combination with metformin (300 mg/kg/day), followed by the estrous cycle, hormonal analysis, and glucose sensitivity test. To evaluate the effect of naringenin on granulosa cell (hGC) steroidogenesis, we treated cells with naringenin (2.5 μM) alone or in combination with metformin (1 mM) in the presence of forskolin (10 μM). To determine the steroidogenesis of CYP‐17A1, ‐19A1, and 3βHSD2, the protein expression levels were examined. Treatment with naringenin in the PCOS animal groups increased ovulation potential and decreased cystic follicles and levels of androgens. The expression levels of CYP‐17A1, ‐19A1, and 3βHSD2, were seen restored in the ovary of PCOS SD rats' model and in the human ovarian cells in response to the naringenin. We found an increased expression level of phosphorylated‐AKT in the ovary and hGCs by naringenin. Naringenin improves ovulation and suppress androgens and cystic follicles, involving AKT activation.
Local algorithms for maximum cut and minimum bisection on locally treelike regular graphs of large degree
Authors: El Alaoui Ahmed , Montanari Andrea , Sellke Mark 
Published: May 2023

AbstractGiven a graph of degree over vertices, we consider the problem of computing a near maximum cut or a near minimum bisection in polynomial time. For graphs of girth , we develop a local message passing algorithm whose complexity is , and that achieves near optimal cut values among all ‐local algorithms. Focusing on max‐cut, the algorithm constructs a cut of value , where is the value of the Parisi formula from spin glass theory, and (subscripts indicate the asymptotic variables). Our result generalizes to locally treelike graphs, that is, graphs whose girth becomes after removing a small fraction of vertices. Earlier work established that, for random ‐regular graphs, the typical max‐cut value is . Therefore our algorithm is nearly optimal on such graphs. An immediate corollary of this result is that random regular graphs have nearly minimum max‐cut, and nearly maximum min‐bisection among all regular locally treelike graphs. This can be viewed as a combinatorial version of the near‐Ramanujan property of random regular graphs.
Pair Interaction between Two Catalytically Active Colloids
Authors: Sharan Priyanka , Daddi‐Moussa‐Ider Abdallah , Agudo‐Canalejo Jaime , Golestanian Ramin , Simmchen Juliane 
Published: May 2023

AbstractDue to the intrinsically complex non‐equilibrium behavior of the constituents of active matter systems, a comprehensive understanding of their collective properties is a challenge that requires systematic bottom–up characterization of the individual components and their interactions. For self‐propelled particles, intrinsic complexity stems from the fact that the polar nature of the colloids necessitates that the interactions depend on positions and orientations of the particles, leading to a 2d − 1 dimensional configuration space for each particle, in d dimensions. Moreover, the interactions between such non‐equilibrium colloids are generically non‐reciprocal, which makes the characterization even more complex. Therefore, derivation of generic rules that enable us to predict the outcomes of individual encounters as well as the ensuing collective behavior will be an important step forward. While significant advances have been made on the theoretical front, such systematic experimental characterizations using simple artificial systems with measurable parameters are scarce. Here, two different contrasting types of colloidal microswimmers are studied, which move in opposite directions and show distinctly different interactions. To facilitate the extraction of parameters, an experimental platform is introduced in which these parameters are confined on a 1D track. Furthermore, a theoretical model for interparticle interactions near a substrate is developed, including both phoretic and hydrodynamic effects, which reproduces their behavior. For subsequent validation, the degrees of freedom are increased to 2D motion and resulting trajectories are predicted, finding remarkable agreement. These results may prove useful in characterizing the overall alignment behavior of interacting self‐propelling active swimmer and may find direct applications in guiding the design of active‐matter systems involving phoretic and hydrodynamic interactions.
Controlling Hot Charge Carrier Transfer in Monolithic AlSiAl Heterostructures for Plasmonic On‐Chip Energy Harvesting
Authors: Song Zehao , Sistani Masiar , Schwingshandl Fabian , Lugstein Alois 
Published: May 2023

AbstractThe generation of hot carriers by Landau damping or chemical interface damping of plasmons is of particular interest to the fundamental aspects of extreme light‐matter interactions. Hot charge carriers can be transferred to an attached acceptor for photochemical or photovoltaic energy conversion. However, these lose their excess energy and relax to thermal equilibrium within picoseconds and it is difficult to extract useful work thereof with thermodynamic efficiencies that are of interest for practical devices. Without a detailed understanding of the underlying plasmon decay processes and transfer mechanisms, proper material matching and design considerations for novel plasmonic devices are extremely challenging. Here, a multifunctional AlSiAl heterostructure device with tunable Schottky barriers is presented to control plasmon‐induced hot carrier injection at an abrupt metal‐semiconductor interface. Light absorption, surface plasmon generation, and separation of hot carriers arising from the non‐radiative decay of surface plasmons are realized in a monolithic Schottky barrier field effect transistor. Aside from barrier modulation, a virtual p–n junction can be emulated in the semiconductor channel with the distinct merit that carrier concentration and polarity are tunable by electrostatic gating. The investigations are carried out with a view to possible use for CMOS‐compatible plasmonic photovoltaics, with versatile implementations for autonomous nanosystems.
Butyrate Modification Promotes Intestinal Absorption and Hepatic Cancer Cells Targeting of Ferroptosis Inducer Loaded Nanoparticle for Enhanced Hepatocellular Carcinoma Therapy
Authors: Yu Yinglan , Shen Xinran , Xiao Xin , Li Lian , Huang Yuan 
Published: May 2023

AbstractSorafenib is an oral‐administered first‐line drug for hepatocellular carcinoma (HCC) treatment. However, the therapeutic efficacy of sorafenib is relatively low. Here, an oral delivery platform that increases sorafenib uptake by HCC and induces potent ferroptosis is designed. This platform is butyrate‐modified nanoparticles separately encapsulated with sorafenib and salinomycin. The multifunctional ligand butyrate interacts with monocarboxylate transporter 1 (MCT‐1) to facilitate transcytosis. Specifically, MCT‐1 is differentially expressed on the apical and basolateral sides of the intestine, highly expressed on the surface of HCC cells but lowly expressed on normal hepatocytes. After oral administration, this platform is revealed to boost transepithelial transport effectively and continuously in the intestine, drug accumulation in the liver, and HCC cell uptake. Following drug release in cancer cells, sorafenib depletes glutathione peroxidase 4 and glutathione, consequently initiating ferroptosis. Meanwhile, salinomycin enhances intracellular iron and lipid peroxidation, thereby accelerating ferroptosis. In vivo experiments performed on the orthotopic HCC model demonstrate that this combination strategy induces pronounced ferroptosis damage and ignites a robust systemic immune response, leading to the effective elimination of tumors and establishment of systemic immune memory. This work provides a proof‐of‐concept demonstration that an oral delivery strategy for ferroptosis inducers may be beneficial for HCC treatment.
Understanding and Preventing Lubrication Failure at the Carbon Atomic Steps
Authors: Yan Wenmeng , Bhuiyan Fakhrul H. , Tang Chuan , Wei Liang , Jiang Yilong , Jang Seokhoon , Liu Yangqin , Wu Jiang , Wang Wen , Wang Yang , Martini Ashlie , Qian Linmao , Kim Seong H. , Chen Lei 
Published: May 2023

AbstractTwo‐dimensional (2D) lamellar materials are normally capable of rendering super‐low friction, wear protection, and adhesion reduction in nanoscale due to their ultralow shear strength between two basal plane surfaces. However, high friction at step edges prevents the 2D materials from achieving super‐low friction in macroscale applications and eventually leads to failure of lubrication performance. Here, taking graphene as an example, the authors report that not all step edges are detrimental. The armchair (AC) step edges are found to have only a minor topographic effect on friction, while the zigzag (ZZ) edges cause friction two orders of magnitude larger than the basal plane. The AC step edge is less reactive and thus more durable. However, the ZZ structure prevails when step edges are produced mechanically, for example, through mechanical exfoliation or grinding of graphite. The authors found a way to make the high‐friction ZZ edge superlubricious by reconstructing the (6,6) hexagon structure to the (5,7) azulene‐like structure through thermal annealing in an inert gas environment. This will facilitate the realization of graphene‐based superlubricity over a wide range of industrial applications in which avoiding the involvement of step edges is difficult.
Liquid Crystalline Elastomer for Separate or Collective Sensing and Actuation Functions
Authors: Jiang Jie , Zhao Yue 
Published: May 2023

AbstractA porous liquid crystalline elastomer actuator filled with an ionic liquid (PLCE‐IL) is shown to exhibit the functions of two classes of materials: electrically responsive, deformable materials for sensing and soft active materials for stimuli‐triggered actuation. On one hand, upon the order–disorder phase transition of aligned mesogens, PLCE‐IL behaves like a typical actuator capable of reversible shape change and can be used to assemble light‐fuelled soft robot. On the other hand, at temperatures below the phase transition, PLCE‐IL is an elastomer that can sustain and sense large deformations of various modes as well as environmental condition changes by reporting the corresponding electrical resistance variation. The two distinguished functions can also be used collectively with PLCE‐IL integrated in one device. This intelligent feature is demonstrated with an artificial arm. When the arm is manually powered to fold and unfold, the PLCE‐IL strip serves as a deformation sensor; while when the manual power is not available, the role of the PLCE‐IL strip is switched to an actuator that enables light‐driven folding and unfolding of the arm. This study shows that electrically responsive LCEs are a potential materials platform that offers possibilities for merging deformable electronic and actuation applications.
Linker Independent Regioselective Protonation Triggered Detoxification of Sulfur Mustards with Smart Porous Organic Photopolymer
Authors: Paul Ratul , Kalita Priyanka , Dao Duy Quang , Mondal Indranil , Boro Bishal , Mondal John 
Published: May 2023

AbstractThe development of efficient metal‐free photocatalysts for the generation of reactive oxygen species (ROS) for sulfur mustard (HD) decontamination can play a vital role against the stockpiling of chemical warfare agents (CWAs). Herein, one novel concept is conceived by smartly choosing a specific ionic monomer and a donor tritopic aldehyde, which can trigger linker‐independent regioselective protonation/deprotonation in the polymeric backbone. In this context, the newly developed vinylene‐linked ionic polymers (TPA/TPD‐Ionic) are further explored for visible‐light‐assisted detoxification of HD simulants. Time‐resolved‐photoluminescence (TRPL) study reveals the protonation effect in the polymeric backbone by significantly enhancing the life span of photoexcited electrons. In terms of catalytic performance, TPA‐Ionic outperformed TPD‐Ionic because of its enhanced excitons formation and charge carrier abilities caused by the donor‐acceptor (D‐A) backbone and protonation effects. Moreover, the formation of singlet oxygen (1O2) species is confirmed via in‐situ Electron Spin Resonance (ESR) spectroscopy and density functional theory (DFT) analysis, which explained the crucial role of solvents in the reaction medium to regulate the (1O2) formation. This study creates a new avenue for developing novel porous photocatalysts and highlights the crucial roles of sacrificial electron donors and solvents in the reaction medium to establish the structure‐activity relationship.
Halogen Interaction Effects on Chiral Self‐Assemblies on Cyclodipeptide Scaffolds Across Hierarchy
Authors: Wang Zhuoer , Hao Aiyou , Xing Pengyao 
Published: May 2023

AbstractHow halogenation affects protein or peptide folding and self‐assembly hierarchically? This study tries to answer this question by using the halogen bonding mediated self‐assemblies on cyclodipeptide scaffolds. Single‐functionalized cyclodipeptides (Cyclo‐GX) based on para‐halogenated phenylalanine in the solid state form homochiral helical nanotubes via consecutive X···O bonds (X = Cl, Br, and I) independent of halogen kinds. In contrast, double‐functionalized cyclodipeptides (Cyclo‐XX) feature versatile self‐assembly architectures depending on the para‐substituents (X = H, F, Cl, Br, and I), affording nanotubular, lamellar, and triple helical nanotubular architectures. Cyclo‐BrBr exclusively adopts intramolecular Type‐IV X···X interaction that alters the molecular folding and packing, which also gives rise to opposite chirality at molecular folding (secondary structure), stacking (tertiary structure), and self‐assembled nanohelices (quarternary structure) at macroscopic scale. It unveils how halogenation impacts on the self‐assembly and chirality at hierarchical levels in specific peptides. Clusteroluminescence is found for the cyclodipeptides, achieving high quantum yield up to 71%, whereby circularly polarized luminescence is realized with tunable handedness by controlling halogen substituents.
Metallaphotocatalytic Amination of Aryl Chlorides Enabled by Highly Crystalline Acetylene‐Based Hydrazone‐Linked Covalent Organic Frameworks
Authors: Yusran Yusran , Xing Jiabin , Lin Qihan , Wu Gang , Peng Wen‐Chang , Wu Yan , Su Tianhui , Yang Lingyi , Zhang Liming , Li Qiaowei , Wang Hui , Li Zhan‐Ting , Zhang Dan‐Wei 
Published: May 2023

AbstractAmination of aryl chlorides by metallaphotocatalysis is highly desired but remains practically challenging. Meanwhile, relying on soluble noble‐metal photocatalysts suffers from resource scarcity and structural instability which limit their practical application. Here in, a highly crystalline acetylene‐based hydrazone‐linked covalent organic framewok‐1 (AC‐COF‐1) is reported that enables metallaphotocatalytic amination of aryl chlorides. The non‐planar effect of hydrazone linkage and weak interlayer attraction of acetylene bond are minimized by intralayer hydrogen‐bonding. As a result, the COF shows not only improved crystallinity and porosity, but also enhanced optical and electronic properties compared to a COF analog without hydrogen‐bonding. Notably, dual AC‐COF‐1/Ni system affords CN coupling products from broad aryl chloride substrates in excellent yields (up to 99%) and good functional tolerance. Furthermore, AC‐COF‐1 is recoverable and reusable for seven times photocatalysis cycles. This report demonstrates simple approach to tune the structure‐activity relationship in COFs at molecular level.
Characterization and Comparison of Wet Milling Fractions of Export Commodity Corn Originating from Different International Geographical Locations
Authors: Singh Shuchi , Bekal Sadia , Duan Jingxin , Singh Vijay 
Published: May 2023

AbstractSoft endosperm corn has evident characteristics suitable for wet milling but is susceptible to breakage and fracture during transportation. In this study the millability of commodity corn samples with different endosperm hardness originating from different international locations is compared, and its economic impact on corn importers for wet milling is discussed. The broken corn and foreign material (BCFM) for the soft endosperm US commodity corn ranges from 1.13% to 5.57% which is higher than other commodity corn from other international locations exported to the same country. US corn exported to different international markets shows higher starch yield in a range of 5–8% compared to the corn from different geographical locations exported to the same market. The excess starch from US corn directly translates to an additional revenue of 8.13–13 million USD per year for a 2540 MT day−1 wet mill plant. Therefore, it can be concluded that the soft endosperm US commodity corn, despite higher breakage, has superior millability and gives higher starch yields compared to the hard endosperm corn from other international locations which has comparatively lower BCFM. There are technologies that can be used to process broken corn separately after the initial cleaning process.
Study on design, preparation, and performance of low‐temperature rising concrete with energy storage aggregate
Authors: Wang Liguo , Wang Lanxin , Ju Siyi , Miao Yanchun , Wang Yuncheng , Wang Fengjuan , Sui Shiyu , Jiang Jinyang 
Published: May 2023

AbstractAlleviating cracks induced by the temperature rise in mass concrete has always been a research hotspot and engineering problem. In this study, a type of energy storage phase change low‐temperature rising concrete was designed and prepared to reduce the cracking risk of mass concrete. First, a type of energy storage coarse aggregate (ESA) was prepared using a semi‐dry method with cement and fly ash as matrix materials, mixed with carbon black (CB), carbon fiber (CF), and phase change material (PCM). Furthermore, the influence of these materials on the mechanical properties, microstructure, and pore structure of the ESA was studied. Subsequently, ESA was used to prepare phase change low‐temperature rising concrete, and its mechanical properties, thermal conductivity (TC), and internal temperature rise were investigated. The research results show that, except for the compressive strength of PCM‐15‐ESA, which is only 7% lower than that of the control, PC‐P0, other samples have no mechanical property deterioration. The double‐layer protection measures can effectively avoid the mechanical property deterioration of concrete induced by PCM leakage. The maximum internal temperature rise of concrete is reduced by 9.8°C, which greatly reduces the risk of cracking of concrete.
Pragmatic verification and validation of industrial executable SysML models
Authors: Horváth Benedek , Molnár Vince , Graics Bence , Hajdu Ákos , Ráth István , Horváth Ákos , Karban Robert , Trancho Gelys , Micskei Zoltán 
Published: May 2023

AbstractIn recent years, Model‐Based Systems Engineering (MBSE) practices have been applied in various industries to design, simulate and verify complex systems. The verification and validation (V&V) of such systems engineering models are crucial to develop high‐quality systems. However, this is a challenging problem due to the complexity of the models and semantic differences in how different tools interpret the models, which can undermine the validity of the obtained results if they go undiscovered. To address these issues, we propose (i) a subset of the SysML language for which the practical semantic integrity of tools can be achieved and (ii) a cloud‐based V&V framework for this subset, lifting verification to an industrial scale. We demonstrate the feasibility of our approach on an industrial‐scale model from the aerospace domain and summarize the lessons learned during transitioning formal verification tools to an industrial context.
Budding uninhibited by benzimidazoles 1 might be a poor prognosis biomarker promoting the progression of papillary thyroid cancer
Authors: Jiang Wenjie , Yu Yan , Bhandari Adheesh , Hirachan Suzita , Dong Xubin , Huang Xiaoli , Qu Jinmiao , Chen Chengze 
Published: May 2023

AbstractBackgroundPapillary thyroid carcinoma (PTC) is one of the most widespread malignant tumors of the endocrine system, with a high incidence. Budding uninhibited by benzimidazoles 1 (BUB1), one of the spindle assembly checkpoint (SAC) genes, is a multitask protein kinase required for eukaryotic chromosome segregation. Although BUB1 has been explored in several types of cancer, its biological role and molecular mechanisms in PTC remain unclear.MethodsIn this study, we performed an examination of four public datasets along with local PTC cohorts and discovered that BUB1 was elevated in PTC compared to non‐cancer tissues. High BUB1 expression was linked with the status of BRAFV600E, RAS, and TERT after statistical analysis.ResultsClinically, BUB1 is associated with a variety of clinicopathological features in PTC patients. Interestingly, analysis of the TCGA database showed that BUB1 was closely associated with poor prognosis of PTC and significantly correlated with PFS. As determined by regression analysis, BUB1, and T stage were independent predictors of PTC and were related to BRAFV600E and lymph node metastatic status. By RT‐qPCR, BUB1 was considerably overexpressed in PTC cell lines in comparison with normal thyroid epithelial cells.ConclusionWe confirmed that the knockdown of BUB1 in BCPAP and TPC1 cell lines significantly inhibited cell proliferation, cloning, and migration in vitro experiments. These results imply that BUB1 may be a significant oncogenic gene that is directly associated with the prognosis of PTC and may represent a future target for therapeutic intervention.
Diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy
Authors: Chen Sheng‐Yuan , Chiu Chien‐Chih , Hung Chun‐Tzu , Pan Wen‐Hsiung , Chen Yen‐Chun , Bow Yung‐Ding , Li Wan‐Ju , Hsu Sheng‐Kai , Lin I‐Ling , Wen Zhi‐Hong , Wu Chang‐Yi 
Published: May 2023

AbstractBreast cancer is a leading cause of cancer‐related death worldwide, and chemoresistance often leads to poor patient outcomes. In this study, we investigated the anticancer activity of synthetic diphenyl disulfide (DPDS) in breast cancer cell lines. DPDS inhibited cellular proliferation and viability in a dose‐dependent manner and reduced colony formation, an index of clonogenicity. Annexin‐V and 7‐AAD double staining showed that DPDS could induce the apoptosis of breast cancer cells. Western blotting of the expression of Bax p21 and its cleaved form p18 suggested the activation of p18 Bax‐induced apoptosis. Furthermore, the increased expression of the autophagy marker LC3B‐II indicated autophagic lysosome accumulation induced by DPDS. Our findings suggest that DPDS has potential as a candidate for treating breast cancer, and further modifications and optimizations are warranted.