bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Design Solutions and Procedures for Ensuring Meaningful Human Control and Interaction with Autonomy: Automated Ferries in Profile
Authors: Thieme Christoph A. , Ramos Marilia A. , Holte Even A. , Johnsen Stig O. , Myklebust Thor , Smogeli Øyvind 
Published: March 2023

AbstractThis chapter summarizes the findings concerning the operation of automated ferries. First, a use-case on a planned passenger ferry in Norway is presented. Next, a gap analysis is carried out on the proposed solution against applicable rules. Finally, the outcome of the gap analysis is used as input for operational procedures, including decision criteria for a safety supervisor and the remote supervision center onshore and the information they need to make decisions. The results can be used when setting requirements for the infrastructure and human–machine interfaces for the safety supervisor and the remote supervision center. The outcome of this study is used in the AutoSafe project to further develop safety measures for automated passenger ferries. Additionally, gaps in the current regulations regarding the operation of automated passenger ferries are described
Conformal model for gravitational waves and dark matter: a status update
Authors: Kierkla Maciej , Karam Alexandros , Świeżewska Bogumiła 
Published: March 2023

Abstract
We present an updated analysis of the first-order phase transition associated with symmetry breaking in the early Universe in a classically scale-invariant model extended with a new SU(2) gauge group. Including recent developments in understanding supercooled phase transitions, we compute all of its characteristics and significantly constrain the parameter space. We then predict gravitational wave spectra generated during this phase transition and by computing the signal-to-noise ratio we conclude that this model is well-testable (and falsifiable) with LISA. We also provide predictions for the relic dark matter abundance. It is consistent with observations in a rather narrow part of the parameter space. We strongly constrain the so-called supercool dark matter scenario based on an improved description of percolation and reheating after the phase transition as well as the inclusion of the running of couplings. Finally, we devote attention to the renormalisation-scale dependence of the results. Even though our main results are obtained with the use of renormalisation-group improved effective potential, we also perform a fixed-scale analysis which proves that the dependence on the scale is not only qualitative but also quantitative.
Light lepton portal dark matter meets the LHC
Authors: Iguro Syuhei , Okawa Shohei , Omura Yuji 
Published: March 2023

Abstract
We examine the sensitivity of the Large Hadron Collider (LHC) to light lepton portal dark matter with its mass below 10 GeV. The model features an extra doublet scalar field and singlet Dirac dark matter, which have Yukawa interactions with left-handed leptons. To correctly produce the dark matter abundance via the thermal freeze-out, a large mass splitting among the extra scalars is required, thus providing a light neutral scalar below $$ \mathcal{O}(10)\textrm{GeV} $$
O

10

GeV
and heavy neutral and charged scalars at the electroweak scale. In this paper, we focus on the electroweak pair-production of the extra scalars with subsequent model-specific scalar decays and evaluate the current constraints with the LHC Run 2 data and the discovery potential at the High Luminosity LHC (HL-LHC). It turns out that a large part of the theoretically allowed parameter space can be tested at the HL-LHC by taking into account complementarity between slepton searches and mono-Z plus missing transverse energy search. We also discuss same-sign charged scalar production as a unique prediction of the model, and the implication of the collider searches in the thermal dark matter scenario.
First results on QCD+QED with C* boundary conditions
Authors:   The RCstar collaboration, Bushnaq Lucius , Campos Isabel , Catillo Marco , Cotellucci Alessandro , Dale Madeleine , Fritzsch Patrick , Lücke Jens , Marinković Marina Krstić , Patella Agostino , Tantalo Nazario 
Published: March 2023

Abstract
Accounting for isospin-breaking corrections is critical for achieving subpercent precision in lattice computations of hadronic observables. A way to include QED and strong-isospin-breaking corrections in lattice QCD calculations is to impose C⋆ boundary conditions in space. Here, we demonstrate the computation of a selection of meson and baryon masses on two QCD and five QCD+QED gauge ensembles in this setup, which preserves locality, gauge and translational invariance all through the calculation. The generation of the gauge ensembles is performed for two volumes, and three different values of the renormalized fine-structure constant at the U-symmetric point, corresponding to the SU(3)-symmetric QCD in the two ensembles where the electromagnetic coupling is turned off. We also present our tuning strategy and, to the extent possible, a cost analysis of the simulations with C⋆ boundary conditions.
Smearing and unsmearing KKLT AdS vacua
Authors: Graña Mariana , Kovensky Nicolas , Toulikas Dimitrios 
Published: March 2023

Abstract
Gaugino condensation on D-branes wrapping internal cycles gives a mechanism to stabilize the associated moduli. According to the effective field theory, this gives rise, when combined with fluxes, to supersymmetric AdS4 solutions. In this paper we provide a ten-dimensional description of these vacua. We first find the supersymmetry equations for type II AdS4 vacua with gaugino condensates on D-branes, in the framework of generalized complex geometry. We then solve them for type IIB compactifications with gaugino condensates on smeared D7-branes. We show that supersymmetry requires a (conformal) Calabi-Yau manifold and imaginary self-dual three-form fluxes with an additional (0,3) component. The latter is proportional to the cosmological constant, whose magnitude is determined by the expectation value of the gaugino condensate and the stabilized volume of the cycle wrapped by the branes. This confirms, qualitatively and quantitatively, the results obtained using effective field theory. We find that exponential separation between the AdS and the KK scales seems possible as long as the three-form fluxes are such that their (0,3) component is exponentially suppressed. As for the localized solution, it requires going beyond SU(3)-structure internal manifolds. Nevertheless, we show that the action can be evaluated on-shell without relying on the details of such complicated configuration. We find that no “perfect square” structure occurs, and the result is divergent. We compute the four-fermion contributions, including a counterterm, needed to cancel these divergences.
Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells
Authors: Eenjes Evelien , Benthem Floor , Boerema-de Munck Anne , Buscop-van Kempen Marjon , Tibboel Dick , Rottier Robbert J. 
Published: March 2023

AbstractPulmonary neuroendocrine (NE) cells represent a small population in the airway epithelium, but despite this, hyperplasia of NE cells is associated with several lung diseases, such as congenital diaphragmatic hernia and bronchopulmonary dysplasia. The molecular mechanisms causing the development of NE cell hyperplasia remains poorly understood. Previously, we showed that the SOX21 modulates the SOX2-initiated differentiation of epithelial cells in the airways. Here, we show that precursor NE cells start to develop in the SOX2 + SOX21 + airway region and that SOX21 suppresses the differentiation of airway progenitors to precursor NE cells. During development, clusters of NE cells start to form and NE cells mature by expressing neuropeptide proteins, such as CGRP. Deficiency in SOX2 resulted in decreased clustering, while deficiency in SOX21 increased both the numbers of NE ASCL1 + precursor cells early in development, and the number of mature cell clusters at E18.5. In addition, at the end of gestation (E18.5), a number of NE cells in Sox2 heterozygous mice, did not yet express CGRP suggesting a delay in maturation. In conclusion, SOX2 and SOX21 function in the initiation, migration and maturation of NE cells.
Patterns of Visual Task-based Functional MRI Activation in Chronic Posterior Cerebral Artery Stroke Patients
Authors: Alkolfat Fatma , Abdel Galeel Aya , Bassiouny Ahmad R. , Eldeeb Hany , Radwan Ahmed , Ashram Yasmine A. 
Published: March 2023

Abstract
Purpose
Stroke is a principal cause of disability worldwide. In motor stroke, the tools for stratification and prognostication are plentiful. Conversely, in stroke causing mainly visual and cognitive problems, there is still no gold standard modality to use. The purpose of this study was to explore the fMRI recruitment pattern in chronic posterior cerebral artery (PCA) stroke patients and to investigate fMRI as a biomarker of disability in these patients.

Methods
The study included 10 chronic PCA stroke patients and another 10 age-matched volunteer controls. The clinical presentation, cognitive state, and performance in visual perceptual skills battery (TVPS-3) were determined for both patients and control groups. Task-based fMRI scans were acquired while performing a passive visual task. Individual and group analyses of the fMRI scans as well as correlation analysis with the clinical and behavioral data were done.

Results
At the level of behavioral assessment there was non-selective global impairment in all visual skills subtests. On visual task-based fMRI, patients recruited more brain areas than controls. These activations were present in the ipsilesional side distributed in the ipsilesional cerebellum, dorsolateral prefrontal cortex mainly Brodmann area (BA) 9, superior parietal lobule (somatosensory associative cortex, BA 7), superior temporal gyrus (BA 22), supramarginal gyrus (BA 40), and contralesional associative visual cortex (BA 19). Spearman’s rank correlation was computed to assess the relationship between the TVPS scores and the numbers of fMRI neuronal clusters in each patient above the main control activations, there was a negative correlation between the two variables, r(10) = −0.85, p ≤ 0.001.

Conclusion
In chronic PCA stroke patients with residual visual impairments, the brain attempts to recruit more neighboring and distant functional areas for executing the impaired visual skill. This intense recruitment pattern in poorly recovering patients appears to be a sign of failed compensation. Consequently, fMRI has the potential for clinically relevant prognostic assessment in patients surviving PCA stroke; however, as this study included no longitudinal data, this potential should be further investigated in longitudinal imaging studies, with a larger cohort, and multiple time points.
RETRACTED ARTICLE: Vitamin D alleviates cognitive dysfunction and brain damage induced by copper sulfate intake in experimental rats: focus on its combination with donepezil
Authors: Elseweidy Mohamed M. , Mahrous Mohamed , Ali Sousou I. , Shaheen Mohamed A. , Younis Nahla N. 
Published: March 2023

Abstract
This study aimed to demonstrate the potential benefits of donepezil (DPZ) and vitamin D (Vit D) in combination to counteract the neurodegenerative disorders induced by CuSO4 intake in experimental rats. Neurodegeneration (Alzheimer-like) was induced in twenty-four male Wistar albino rats by CuSO4 supplement to drinking water (10 mg/L) for 14 weeks. AD rats were divided into four groups: untreated AD group (Cu-AD) and three treated AD groups; orally treated for 4 weeks with either DPZ (10 mg/kg/day), Vit D (500 IU/kg/day), or DPZ + Vit D starting from the 10th week of CuSO4 intake. Another six rats were used as normal control (NC) group. The hippocampal tissue content of β-amyloid precursor protein cleaving enzyme 1 (BACE1), phosphorylated Tau (p-tau), clusterin (CLU), tumor necrosis factor-α (TNF-α), caspase-9 (CAS-9), Bax, and Bcl-2 and the cortical content of acetylcholine (Ach), acetylcholinesterase (AChE), total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured. Cognitive function tests (Y-maze) and histopathology studies (hematoxylin and eosin and Congo red stains) and immunohistochemistry for neurofilament. Vit D supplementation alleviated CuSO4-induced memory deficits including significant reduction hippocampal BACE1, p-tau, CLU, CAS-9, Bax, and TNF-α and cortical AChE and MDA. Vit D remarkably increased cortical Ach, TAC, and hippocampal Bcl-2. It also improved neurobehavioral and histological abnormalities. The effects attained by Vit D treatment were better than those attained by DPZ. Furthermore, Vit D boosted the therapeutic potential of DPZ in almost all AD associated behavioral and pathological changes. Vit D is suggested as a potential therapy to retard neurodegeneration.
Toward the future of OECD/ISO biodegradability testing-new approaches and developments
Authors: Strotmann Uwe , Thouand Gerald , Pagga Udo , Gartiser Stefan , Heipieper Hermann J. 
Published: March 2023

Abstract
In the past decades, industrial and scientific communities have developed a complex standardized system (e.g., OECD, ISO, CEN) to evaluate the biodegradability of chemical substances. This system includes for OECD three levels of testing (ready and inherent biodegradability tests, simulation tests). It was adopted by many countries and is completely integrated into European legislation (registration, evaluation, authorization, and restriction of chemicals, REACH). Nevertheless, the different tests have certain deficiencies, and the question arises of how accurately these tests display the situation in the real environment and how the results can be used for predictions. This review will focus on the technical advantages and weaknesses of current tests concerning the technical setup, the inoculum characterization, and its biodegradation potential as well as the use of adequate reference compounds. A special focus of the article will be on combined test systems offering enhanced possibilities to predict biodegradation. The properties of microbial inocula are critically discussed, and a new concept concerning the biodegradation adaptation potential (BAP) of inocula is proposed. Furthermore, a probability model and different in silico QSAR (quantitative structure-activity relationships) models to predict biodegradation from chemical structures are reviewed. Another focus lies on the biodegradation of difficult single compounds and mixtures of chemicals like UVCBs (unknown or variable composition, complex reaction products, or biological materials) which will be an important challenge for the forthcoming decades.

Key points
• There are many technical points to be improved in OECD/ISO biodegradation tests
• The proper characterization of inocula is a crucial point in biodegradation tests
• Combined biodegradation test systems offer extended possibilities for biodegradation tests
The role of adjuvant pharmacotherapy with liraglutide for patients with inadequate weight loss following bariatric surgery
Authors: Colbourne James R. M. , Fisher Oliver M. , Mo Shirley , Rigas Georgia S. , Talbot Michael L. 
Published: March 2023

Abstract
Purpose
Despite the benefits of bariatric surgery for many patients, there are a proportion of patients who do not achieve adequate weight loss. We evaluate the role of liraglutide as adjuvant pharmacotherapy in those who respond poorly to weight loss surgery.

Materials and Methods
A non-controlled, prospective, open-label cohort study in which participants are prescribed liraglutide following inadequate response to weight loss surgery. The efficacy and tolerability of liraglutide was measured through measurement of BMI and monitoring of side effect profile.

Results
A total of 68 partial responders to bariatric surgery were included in the study, 2 participants were lost to follow-up. Overall 89.7% lost weight on liraglutide, with 22.1% showing a good response (>10% total body weight loss). There were 41 patients who discontinued liraglutide mainly due to cost.

Conclusion
Liraglutide is efficacious in achieving weight loss and reasonably well tolerated in patients who have inadequate weight loss post-bariatric surgery.
Differential–algebraic systems with dissipative Hamiltonian structure
Authors: Mehrmann Volker , van der Schaft Arjan 
Published: March 2023

AbstractDifferent representations of linear dissipative Hamiltonian and port-Hamiltonian differential–algebraic equations (DAE) systems are presented and compared. Using global geometric and algebraic points of view, translations between different representations are presented. Characterizations are also derived when a general DAE system can be transformed into one of these structured representations. Approaches for computing the structural information and the described transformations are derived that can be directly implemented as numerical methods. The results are demonstrated with a large number of examples.
Rendering massive indoor point clouds in virtual reality
Authors: Casado-Coscolla Alvaro , Sanchez-Belenguer Carlos , Wolfart Erik , Sequeira Vitor 
Published: March 2023

AbstractThis paper addresses the challenges of rendering massive indoor point clouds in Virtual Reality. In these kind of visualizations the point of view is never static, imposing the need of a one-shot (i.e. non-iterative) rendering strategy, in contrast with progressive refinement approaches that assume that the camera position does not change between most consecutive frames. Our approach benefits from the static nature of indoor environments to pre-compute a visibility map that enables us to boost real-time rendering performance. The key idea behind our visibility map is to exploit the cluttered topology of buildings in order to effectively cull the regions of the space that are occluded by structural elements such as walls. This does not only improve performance but also the visual quality of the final render, allowing us to display in full detail the space and preventing the user to see the contiguous spaces through the walls. Additionally, we introduce a novel hierarchical data structure that enables us to display the point cloud with a continuous level of detail with a minimal impact on performance. Experimental results show that our approach outperforms state-of-the-art techniques in complex indoor environments and achieves comparable results in outdoor ones, proving the generality of our method.
Association between periodontal diseases and COVID-19 infection: a case–control study with a longitudinal arm
Authors: Sari Aysegul , Dikmen Nursel Kaya , Nibali Luigi 
Published: March 2023

AbstractSome studies have suggested potential relationships between periodontal disease and COVID-19, explained by many possible pathological pathways. The aim of this case–control study with a longitudinal arm was to investigate this association. 80 systemically healthy individuals (apart from COVID-19) were involved in this study, divided into 40 patients who had recently had COVID-19 (test, divided into severe and mild/moderate cases) and 40 who had not had COVID-19 (control). Clinical periodontal parameters and laboratory data were recorded. Mann–Whitney U test, Wilcoxon test, and chi-square test were performed to compare variables. Multiple binary logistic regression method was used to estimate adjusted ORs and 95% confidence interval. Hs-CRP-1 and 2, Ferritin-1 and 2, lymphocyte count-1 values, and neutrophil/lymphocyte ratio-1 were higher in patients with severe COVID-19 than patients with mild/moderate COVID-19 (p < 0.05). All of these laboratory values significantly decreased after COVID-19 treatment (p < 0.05) in the test group. Presence of periodontitis (p = 0.015) was higher and periodontal health was lower (p = 0.002) in the test group than in the control group. All clinical periodontal parameters were significantly higher in the test group than in the control group (p < 0.05), except plaque index. Prevalence of periodontitis was associated with increased odds of having COVID-19 infection (PR = 1.34; 95% CI 0.23–2.45) in the multiple binary logistic regression. COVID-19 is associated with periodontitis prevalence, through a series of possible mechanisms including local and systemic inflammatory responses. Further studies should investigate whether the maintenance of periodontal health may be a factor in the reduction of the severity of COVID-19 infections.
Heuristics Facilitates the Evolution of Transitive Inference and Social Hierarchy in a Large Group
Authors: Doi Kazuto , Nakamaru Mayuko 
Published: March 2023

AbstractTransitive inference (TI) refers to social cognition that facilitates the discernment of unknown relationships between individuals using known relationships. It is extensively reported that TI evolves in animals living in a large group because TI could assess relative rank without deducing all dyadic relationships, which averts costly fights. The relationships in a large group become so complex that social cognition may not be developed adequately to handle such complexity. If members apply TI to all possible members in the group, TI requires extremely highly developed cognitive abilities especially in a large group. Instead of developing cognitive abilities significantly, animals may apply simplified TI we call reference TI in this study as heuristic approaches. The reference TI allows members to recognize and remember social interactions only among a set of reference members rather than all potential members. Our study assumes that information processes in the reference TI comprises (1) the number of reference members based on which individuals infer transitively, (2) the number of reference members shared by the same strategists, and (3) memory capacity. We examined how information processes evolve in a large group using evolutionary simulations in the hawk–dove game. Information processes with almost any numbers of reference members could evolve in a large group as long as the numbers of shared reference member are high because information from the others’ experiences is shared. TI dominates immediate inference, which assesses relative rank on direct interactions, because TI could establish social hierarchy more rapidly applying information from others’ experiences.