bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of using acalabrutinib therapy in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Piskunova I. S. , Moiseeva T. N. , Al-Radi L. S. , Plastinina L. V. 
Published: December 2022

Introduction. Thanks to scientific advances and discoveries in the study of tumor cell biology, new effective drugs for the treatment of chronic lymphocytic leukemia/ small lymphocytic lymphoma have emerged. Currently, there are drugs with different application points at the molecular level. One such drug is acalabrutinib, which is a selective second-generation inhibitors of Bruton tyrosine kinase and has a more favorable toxicity profile.Objective. To evaluate the efficacy of acalabrutinib in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.Materials and methods. Since February 2020 acalabrutinib (100 mg 2 p/day orally) has been administered to 7 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (mean age 64 years) at the Hematology Research Center. Six patients received acalabrutinib in 1st-line therapy and one patient received acalabrutinib in 2nd-line therapy. The mean comorbidity index (CIRS) of the patients was 10 points (range, 8 to 14). Most patients had at least one of the adverse prognostic factors - IGHV nonmutated gene status, TP53 gene aberration (del17p13 and/or TP53 gene mutation), complex karyotype disorders.Results. All patients achieved partial remission of the disease (overall response 100% in the form of regression of B-symptoms, lymphocytic leukocytosis, splenomegaly) at the control period of treatment with acalabrutinib +12 months. The most frequent adverse events when taking acalabrutinib were the occurrence of headache in the first month of taking the drug, spontaneous subcutaneous hematomas. No hematologic toxicity, infectious complications, or cardiac complications were noted. At a median follow-up of 34 months, no patient showed disease progression.Conclusions. The selective Bruton tyrosine kinase inhibitor acalabrutinib has demonstrated high efficacy in patients with adverse risk factors, good tolerability and minimal toxicity, including in comorbid patients.
İngiliz Siyasi Subay H.C. Luke’un Güney Kafkasya Raporu (4 Kasım 1919)
Authors: TURAN Orhan 
Published: December 2022

Bolşevik İhtilâli, Çarlık Rusyası egemenliğindeki uluslar için yeni bir dönemin habercisi oldu. Rus İmparatorluğu’nun sürüklendiği iç savaş atmosferi bağımsızlık hareketleri için elverişli bir ortam sağladı. Kısa süre içerisinde Güney Kafkasya’da Azerbaycan, Ermenistan ve Gürcistan’ın oluşturduğu federatif bir yapı ortaya çıktı. Daha açık bir ifadeyle 1918 Nisan’ında Transkafkasya Bağımsız Demokratik Federatif Cumhuriyeti kuruldu. Ardından üç devlette bağımsızlıklarını ilan etti. I. Dünya Savaşı’nın sona ermesiyle birlikte Kafkasya’nın da kaderi değişmeye başladı.
İngiltere, Osmanlı Devleti’nin mütareke isteyerek savaştan çekilmesiyle Güney Kafkasya’ya odaklandı. Zira Kafkaslar stratejik ve ekonomik açıdan İngiltere için büyük önem arz etmekteydi. Buradaki yeraltı enerji kaynakları ile Batum, Tiflis ve Bakü güzergâhı imparatorluğun himayesi altında olmalı idi. Bu bağlamda İngiltere mütareke koşullarını kendi çıkarları doğrultusunda olabildiğince zorladı. Öyle ki bölgenin önemli şehir merkezlerinde askeri üsler bile inşa etti.
Çalışmada 4 Kasım 1919 tarihli İstanbul’daki Yüksek Komiser Amiral J. de Robeck’in görevlendirdiği Siyasi Subay H. C. Luke’un hazırladığı Londra’da İngiliz Milli Arşivinden temin edilen “Report on the Situation in Transcaucasia” başlıklı rapor değerlendirilecektir. Mevcut rapor Bolşevik İhtilâli’nden sonra Güney Kafkasya’daki siyasi ve askeri gelişmeleri ortaya koymaktadır. Rapor özellikle Gürcistan, Azerbaycan ve Ermenistan özelinde yaşanan olayları İngiliz bakış açısından ele almaktadır. Yine Türk, Alman, Rus başta olmak üzere diğer ulusların bölgeye olan etkisi de burada dile getirilmiştir.
Çalışma, Mondros Mütarekesi sonrası dönemde Güney Kafkasya’da ortaya çıkan siyasi ve askeri gelişmeler ışığında büyük ve yerel güçler arasında yaşanan rekabeti rapor doğrultusunda ele almaya gayret edecektir. Konunun ana malzemesini, İngiliz Milli Arşivi’nden elde edilen Report on the Situation in Transcaucasia başlıklı rapor temel oluşturacaktır.
Saltanatın Kaldırılması Sürecinde Refet Paşa’nın Siyasal Söylemlerinin İç ve Dış Basında Yansımaları
Authors: AKÇA Seher 
Published: December 2022

Milli Mücadelenin cephelerde yürütülen askeri safhası, 1922 yılında zaferle sonuçlandırılmıştır. Batı Cephesinde Sakarya Savaşı’yla ileri harekâta geçen Türk Ordusu, Ağustos 1922’de Büyük Taarruz ve Başkomutan Meydan Muharebesi ile kesin zafere ulaşmıştır. Bundan sonraki süreç, askeri zaferin diplomasi zaferiyle taçlandırılması olacak; bu zafer de, Mudanya Mütarekesi ve Lozan Barış Anlaşması ile kazanılacaktır.
Mudanya Mütarekesi, Türk-Yunan kuvvetleri arasındaki filli savaş durumuna son vermiş ve ileride yapılacak barış anlaşmasına zemin hazırlamıştır. Mütareke hükümleri gereğince en önemli husus ise, Edirne dâhil olmak üzere Doğu Trakya’nın kademeli olarak Yunan kuvvetleri ve müttefikler tarafından boşaltılması, Ankara Hükümetine teslim edilmesi olmuştur. Ankara Hükümeti Refet Paşayı Trakya’yı teslim almakla görevlendirmiş; kendisine, Ankara Hükümetini İstanbul’da temsil etme yetkisini de vermiştir.
Bu çalışmada TBMM tarafından resmi olarak görevlendirilen Refet Paşa’nın İstanbul’da saltanat idaresine yönelik nutukları ve saltanat-hilafet makamları nezdinde takındığı tutum ve davranışları, saltanatın kaldırılma sürecindeki yeri ve bu sürecin iç ve dış basında yansımaları itibariyle değerlendirilecektir.
Cultural Heritage as a Factor of Cooperation between Countries of the Balkan Region
Authors: HAJZERİ Pajazit 
Published: December 2022

Cultural heritage as factors of cooperation and interaction is one of the challenges facing Southeast Europe, more specifically the Western Balkans.
The historical past and cultural diversity of each country in this region is closely related to its past, with monuments of construction heritage, movable, immovable, sacred and secular monuments, of different faiths, with social, religious character etc.
Cultural diversity in heritage is the most complex and challenging area in terms of our past as a region, so regional cooperation is more than necessary to channel the facts and equate historical evidence to mitigate the irritations and territorial claims of neighbors to the detriment. of others.
Kosovo in particular has a number of problems related to the historical past closely linked to cultural heritage as a result of non-recognition by UNESCO leaving room for others to make claims.
Special areas protected by the Ahtisaari Package were erected around some Orthodox cult monuments to usurp the surrounding properties under the pretext of security, while the properties were private (the case is with the Boletin church in Mitrovica district which usurped the lands of Isa's family Bulletin).
All this situation would have ended if UNESCO had recognized the cultural heritage of Kosovo as the heritage of Kosovo regardless of which ethnicity or cult it belongs to, aiming at regional cooperation in the cultural diversity that surrounds us.
Osmanlı Modernleşme Döneminde Sason’da Eğitim
Authors: YILDIZ Hatip 
Published: December 2022

Güneydoğu Anadolu Bölgesinin Yavuz Selim Dönemi’nde Osmanlı hâkimiyetine girmesiyle, Batman ilinin bugünkü sınırları içinde yer alan Sason kazası ile bağlı nahiye ve köylerin tamamı uzun yıllar Diyarbekir Vilayetinin idari yapısı içerisinde yer almıştır. Fakat 1879 yılında Bitlis Vilayetinin teşekkülüyle Sason kazası Diyarbekir Vilayetinden ayrılarak buraya bağlanmıştır. Bu durum, tespit edilebildiği kadarıyla Osmanlı Devleti’nin sonuna kadar aynı şekilde devam etmiştir.
Osmanlı Devleti’nde Tanzimat Fermanı’nın ilanından sonra daha planlı bir şekilde yürütülen modernleşme çalışmaları, İstanbul’un dışında yani vilayetlerde de peyderpey hayata geçirilmiştir. Bu dönemde merkezde olduğu gibi taşrada da yenilik yapılan alanlardan biri de eğitimdir. Bilhassa 19. yüzyılın ikinci yarısından itibaren vilayetlerde farklı düzeylerde pek çok modern eğitim kurumu açılmaya başlanmıştır. Bu doğrultuda Sason kazasında da Maarif Nezaretine bağlı olarak çok sayıda yeni okul açılmış olup başlıcaları Sason (Hazzo), Bozikan, Kabılcevz, Tızi, Reşnik, Cemalan, Hatni, Asi ve Koskit ibtidaileri ile Hazzo Hamidiye İbtidaisi ve Hazzo Rüşdiyesidir. Bu Müslüman okullarının yanı sıra Hazzo (Kozluk)’da bir Ermeni mektebi de açılmıştır.
Bu çalışmada, söz konusu ibtidai ve rüşdiye mekteplerinin açılışları ile öğretmen, öğrenci, ders, eğitim ve mali durumları ayrıntılı olarak incelenmiştir. Böylece sosyokültürel yapısından dolayı bilhassa Sultan II. Abdülhamid Dönemi’nde eğitim düzeyinin yükseltilmesine oldukça önem verilen Sason kazasının modern eğitim yapısı ve bölgede izlenen eğitim politikaları ana hatlarıyla ortaya konulmuştur.
Çalışmanın hazırlanmasında Maarif Salnameleri, Maarif İstatistikleri, Bitlis Vilayet Salnameleri, Osmanlı Arşivi Maarif Nezareti belgeleri ve konuyla ilgili araştırma eserlerden faydalanılmıştır.
Quantifying the impact of climate change and human activities on the eco-hydrological regimes of the Weihe River Basin, Northwest China
Authors: Jiang Shanhu , Liu Yating , Wang Menghao , Zhu Yongwei , Cui Hao , Du Shuping , Xu Chong-Yu 
Published: December 2022

Abstract
Climate change and anthropogenic interventions have obviously altered the eco-hydrological regimes. A quantitative evaluation and attribution of the eco-hydrological alterations are urgently required. In this study, we evaluated the various attributions of eco-hydrological regimes in the Weihe River Basin (WRB). Firstly, the trends and change-point analysis of hydrological elements were examined, and the natural streamflow was reproduced based on the variable infiltration capacity model. Then, the most ecologically relevant hydrological indicators (ERHIs) were selected and combined with the eco-deficit and eco-surplus indicators to assess the degree of eco-hydrological regime alterations. Finally, the relative contributions to eco-hydrological alterations were quantified using the ‘simulated–observed comparison’ method. The results showed that (1) the streamflow of the WRB exhibited significant decreasing trends (p &lt; 0.01), and a significant change point (p &lt; 0.01) of the streamflow series was identified in 1990. (2) Seven representative indicators of hydrological alteration were selected as ERHIs. (3) During the human-induced period (1991–2017), human activities were the dominant factors in the eco-hydrological alterations as well as the variations of the ERHI indexes and the eco-deficit and eco-surplus metrics. Overall, the proposed framework may improve the understanding of the driving forces of eco-hydrological regime alterations under a changing environment.
Diffusion of point source pollution at the cross joint
Authors: Sun Bin , Peng Qingfeng , Ma Wenjun , Li Zhiwei , Song Zhanqi , Tong An 
Published: December 2022

Abstract
The cross joint is one of the standard connection types for urban water supply pipelines. A pipeline containing cross joints was taken as the research object using NaCl as the tracer. The turbulent mixing characteristics of water and pollutants at the cross joints and pollutant migration and diffusion were studied and analysed by numerical analysis and experimental measurement. The primary purpose is to check the comprehensive influence of the six factors of pipe diameter, inlet flow ratio, outlet flow ratio, location of damage point, flow of brine, and density of brine on the turbulent mixing of water and brine in the pipeline. The coefficient of variation is used as an evaluation index to evaluate the mixing in the pipeline, and the effective mixing length LEML is used to quantify the uniform mixing position of brine in the pipeline. The results show that the inlet flow ratio, outlet flow ratio, and pipe diameter significantly affect LEML in the east outlet of the cross joint. Outlet flow ratio and pipe diameter significantly affect LEML in the cross joint's south outlet direction. In addition, the dimensionless relationship equation representing LEML is fitted through dimensional analysis.
User-Generated-Content and Millennial Moms' Birthplace Decision-Making Process
Authors: Ismail Farah Raihana , Jantan Amer Hamzah , Othman Norashida , Islam Md Asadul 
Published: December 2022

Consumer reviews and experiences on UGC platforms are interoperable decision-making sources. Revolutionized UGC communication platform has changed millennial moms' birthplace decision-making process. They are rising concerns that UGC may lead to unsafe birth practices and risk the safety of the mother and baby. This preliminary qualitative study objective focused on exploring how other birth experiences shared over the UGC platform influence millennial moms' birthplace decisions. Preliminary findings identified two themes: verification and ratification and visibility and trustworthiness. The study provides in-depth information that aids policymakers, service providers, and marketers in understanding the millennial birthplace decision-making process from the consumers' perspective.
Keywords: user-generated-content; decision-making process; experience; information search
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i22.4151
Factors Influencing Adoption and Use of Telemedicine Services in Rural Areas of China: Mixed Methods Study
Authors: Du Yumeng , Zhou Qiru , Cheng Weibin , Zhang Zhang , Hoelzer Samantha , Liang Yizhi , Xue Hao , Ma Xiaochen , Sylvia Sean , Tian Junzhang , Tang Weiming 
Published: December 2022

Background
The shortage of medical resources in rural China reflects the health inequity in resource-limited settings, whereas telemedicine could provide opportunities to fill this gap. However, evidence of patient acceptance of telemedicine services from low- and middle-income countries is still lacking.

Objective
We aimed to understand the profile of patient end-user telemedicine use and identify factors influencing telemedicine service use in rural China.

Methods
Our study followed a mixed methods approach, with a quantitative cross-sectional survey followed by in-depth semistructured interviews to describe telemedicine use and its associated factors among rural residents in Guangdong Province, China. In the quantitative analysis, explanatory variables included environmental and context factors, household-level factors, individual sociodemographic factors, access to digital health care, and health needs and demand factors. We conducted univariate and multivariate analyses using Firth logistic regression to examine the correlations of telemedicine uptake. A thematic approach was used, guided by the Social Cognitive Theory for the qualitative analysis.

Results
A total of 2101 households were recruited for the quantitative survey. With a mean age of 61.4 (SD 14.41) years, >70% (1364/2101, 72.94%) of the household respondents were male. Less than 1% (14/2101, 0.67%) of the respondents reported experience of using telemedicine. The quantitative results supported that villagers living with family members who had a fever in the past 2 weeks (adjusted odds ratio 6.96, 95% CI 2.20-21.98; P=.001) or having smartphones or computers (adjusted odds ratio 3.71, 95% CI 0.64-21.32; P=.14) had marginally higher telemedicine uptake, whereas the qualitative results endorse these findings. The results of qualitative interviews (n=27) also supplemented the potential barriers to telemedicine use from the lack of knowledge, trust, demand, low self-efficacy, and sufficient physical and social support.

Conclusions
This study found extremely low use of telemedicine in rural China and identified potential factors affecting telemedicine uptake. The main barriers to telemedicine adoption among rural residents were found, including lack of knowledge, trust, demand as well as low self-efficacy, and insufficient physical and social support. Our study also suggests strategies to facilitate telemedicine engagement in low-resource settings: improving digital literacy and self-efficacy, building trust, and strengthening telemedicine infrastructure support.
Growth and phytochemical properties in differences weight of porang bulbil (Amorphophallus muelleri B.) var. Madiun 1
Authors: Putri Widya Kristiyanti , Restanto Didik Pudji , Rusdiana Riza Yuli , Kriswanto Budi 
Published: December 2022

The increase of Indonesian’s porang export has led into a new opportunity for better prosperity of local farmers. Thus, the demand for porang’s bulbil/ katak has risen due to its function for vegetative propagation. This study aimed to observe the growing and phytochemicals properties of porang tubers from bulbil with 10 bulbil weight categories samples, which were 0.5 g, 1 g, 1.5 g, 2 g, 2.5 g, 3 g, 3.5 g, 4 g, 4.5 g, and 5 g. The parameters observed were statistically analyzed in PAST 4.03. This study was conducted for three months and the results showed that samples from bulbil weighing 5 g had significant higher value than the others for the plant height, crown diameter, and stem diameter, but bulbil samples with other weights did not show any significant difference in porang tuber growth. Phytochemical’s analysis for dissolved protein resulting in 0.5 g weight sample was the best of all but random results for carbohydrate, antioxidants, polyphenol, and saponin.
Improvement on yield of onion (Allium cepa L.) using different rates of organic manure and sowing seasons in South Eastern Nigeria
Authors: Ishieze Patience Ukamaka , Onah Felicity Chidiebere , Dauda Nathaniel 
Published: December 2022

This study aimed at determining how different rates of poultry manure affected the growth and production of onions (Allium cepa L.) in wet and dry seasons. The experiment was conducted from July to October 2019 and from January to April 2020 at the Department of Crop Science teaching and research farm, University of Nigeria Nsukka, South Eastern Nigeria. The experiment applied a randomized complete block design with nine replications spread over three blocks. The treatments were four doses of poultry manure (0, 10, 20 and 30 t.ha-1) tried in two seasons (wet and dry season). Prior to the investigations, soil analysis of the experimental site and poultry manure nutrient content were carried out. The growth pattern and yield was higher during the wet season. Poultry manure at amount of 30 t.ha-1 gave the best growth attributes (number of leaves, leaf length, and leaf diameter) 14.22, 53.67 cm and 0.88 cm respectively while the 20 t.ha-1 had the highest plant height and bulb fresh weight, 60.86 cm and 2 kg/plant respectively. The trend was not the same as in dry season planting because 20 t.ha-1 poultry manure differs significantly from other rates of poultry manure considered. Plant height, leaf length, leaf diameter and bulb fresh weight (57.64 cm, 55.28 cm, 0.84 cm and 0.63 kg/plant respectively) were statistically significantly (p < 0.05) different at 5% probability level. Utilization of 20 t.ha-1 of poultry manure and planting in wet season gave the best growth and yield of onion vegetable.
CORRELAÇÃO ENTRE COMPORTAMENTOS DE CIDADANIA ORGANIZACIONAL, ESPIRITUALIDADE E SATISFAÇÃO: ESTUDO EM UMA PREFEITURA DO RS
Authors: Malheiros Michel Barboza , De Andrade Taís , Flores Ferreira Thais , Loureiro de Ávila Costa Gabrielle 
Published: December 2022

Objetivo: Identificar a relação entre os Comportamentos de Cidadania Organizacional (CCO), Espiritualidade e Satisfação no Ambiente de Trabalho (EAT e ST).
Método/abordagem: Este estudo é de abordagem quantitativa e descritiva, com a utilização de uma estratégia survey. Para a coleta de dados foi utilizado um questionário contendo 53 perguntas, aplicados a todos os 233 trabalhadores de uma prefeitura do RS. Para os resultados foram utilizados as análises descritivas e Correlação de Pearson.
Principais resultados: Os resultados revelam a existência de uma relação direta e positiva entre os construtos CCO, EAT e ST. O que sinaliza a existência dos CCO, vivência da espiritualidade e índices de satisfação na prefeitura de acordo com a perspectiva dos trabalhadores do referido setor.
Contribuições metodológicas/sociais/gerenciais: Este estudo contribui para que os gestores de organizações públicas possam compreender a importância das temáticas trabalhadas e como elas se relacionam com o trabalho. Além disso, os resultados revelam que os CCO podem contribuir para o bom funcionamento das organizações, principalmente, considerando a dimensão espiritual e a satisfação.
Originalidade/relevância: O estudo se revela como o primeiro realizado com a proposta de identificar as relações entre os construtos no setor público. Considerando os construtos, este estudo visa contribuir para uma maior compreensão e seu impacto no ambiente laboral. Ainda, este estudo contribui para o desenvolvimento teórico das temáticas em âmbito nacional e internacional.
The effect of Glucagon-Like Peptide-1 Receptor Blockade on glucagon-induced stimulation of insulin secretion
Authors: Farahani Rahele A. , Egan Aoife M. , Welch Andrew A. , Laurenti Marcello C. , Cobelli Claudio , Man Chiara Dalla , Vella Adrian 
Published: December 2022

<p>Data from transgenic rodent models suggest that glucagon acts as an insulin secretagogue by signalling through the Glucagon-Like Peptide-1 Receptor (GLP1R) present on β-cells. However, its net contribution to physiologic insulin secretion in humans is unknown. To address this question, we studied non-diabetic individuals in 2 separate experiments. Each subject was studied on 2 occasions in random order. In the first experiment, during a hyperglycemic clamp, glucagon was infused at 0.4ng/kg/min, increasing by 0.2ng/kg/min every hour for 5 hours. On one day exendin-9,39 (300pmol/kg/min) was infused to block GLP1R, while on the other saline was infused. The insulin secretion rate (ISR) was calculated by nonparametric deconvolution from plasma concentrations of C-peptide. Endogenous glucose production (EGP) and glucose disappearance (Rd) were measured using the tracer-dilution technique. Glucagon concentrations, by design, did not differ between study days. Integrated ISR was lower during exendin-9,39 infusion (213 ± 26 vs. 191 ± 22 nmol per 5 hr, saline vs. exendin-9,39 respectively, <em>p</em> = 0.02). In the separate experiment, exendin-9,39 infusion, compared to saline infusion, also decreased the β-cell secretory response to a 1mg glucagon bolus. These data show that in non-diabetic humans, glucagon partially stimulates the β-cell through GLP1R. </p>