bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impairments following COVID-19 infection: Manifestations and investigations of related factors
Authors: Badinlou Farzaneh , Forsström David , Jansson-Fröjmark Markus , Abzhandadze Tamar , Lundgren Tobias 
Published: December 2022

Abstract
The COVID-19 pandemic had a major global impact on the health and wellbeing for many individuals. Even though the infection rates have gone down due to the availability of vaccines, the consequences of the disease are still present due to persistent symptoms among individuals. The aim of the current study was to map long-term impairments in individuals infected with COVID-19 by applying the framework of the World Health Organization’s International Classification of Functioning, Disability and Health (ICF) and also investigate the factors related to the context of an individual’s life influencing the impairments. A web-survey that targeted individuals that had been infected with COVID-19 was used. The survey included a range of measures covering contextual factors and factors related to body functions and structures and post-COVID impairments. A total of 501 individuals were included in the study. Many of the respondents endorsed different impairments due to COVID-19 infection and the most frequent one was fatigue. Severity of COVID-19 infection appeared as the strongest risk factor for post-COVID impairments. Based on the results, interventions can be tailored to help individuals with post-COVID-19 condition. This could be one way lessening the effect of COVID-19 on health care and society as a whole.
WNT pathway in focal cortical dysplasia compared to perilesional nonlesional tissue in refractory epilepsies
Authors: Marinowic Daniel , Zanirati Gabriele , Xavier Fernando , Varelle Fabio , Azevedo Sofia , Ghilardi Isadora , Pereira-Neto Normando , Koff Marco , Paglioli Eliseu , Palmini André , de Abreu José Garcia , Machado Denise , Costa Jaderson Da 
Published: December 2022

Abstract

Background:Focal cortical dysplasia (FCD) is a malformation of cortical development that causes medical refractory seizures, and one of the main treatment may be surgical resection of the affected area of the brain. People affected by FCD may present with seizures of variable severity since childhood. Despite many medical treatments available, only surgery can offer cure. The pathophysiology of the disease is not yet understood;however, it is known that several gene alterations may play a role. The WNT/β-catenin pathway is closely related to the control and balance of cell proliferation and differentiation in the central nervous system. The aim of this study was to explore genes related to the WNT/β-catenin pathway in lesional and perilesional brain tissue in patients with FCD type II.Methods:Dysplastic and perilesional tissue from the primary dysplastic lesion of patients with FCD type IIa were obtained from two patients who underwent surgical treatment. The analysis of the relative expression of genes was performed by a qRT-PCR array (super array) containing 84 genes related to the WNT pathway.Results:Our results suggest the existence of molecular alteration in some genes of the WNT pathway in tissue with dysplastic lesions and of perilesional tissue. We call this tissue of normal-appearing adjacent cortex (NAAC). Of all genes analyzed, a large number of genes showsimilar behavior between injured, perilesional and control tissues. However, some genes have similar characteristics between the perilesional and lesional tissue and are different from the control brain tissue, presenting the perilesional tissue as a molecularly altered material.Conclusion:Our results suggest that the perilesional area after surgical resection of tissue with cortical dysplasia presents molecular changes that may play a role in the recurrence of seizures in these patients. The perilesional tissue should receive expanded attention beyond the somatic mutations described and associated with FCD, such as mTOR, for example, to new signaling pathways that may play a crucial role in seizure recurrence.
Explosive strength and dynamic balance as determinants of the single leg hop test: cross-sectional study among young elite female basketball athletes
Authors: Domínguez-Navarro Fernando , Casaña Jose , Perez-Dominguez Borja , Ricart-Luna Borja , Cotolí-Suárez Pedro , Calatayud Joaquin 
Published: December 2022

Abstract
Objective
To analyze the impact of balance, lower-limb explosive strength and anthropometric variables on the result of the hop test in young elite female basketball athletes.
Methods
Ninety young elite female basketball athletes (13–17 years), without current or recent lower-limb injury, were assessed in the off-season period of July 2021. Single leg hop test, countermovement jump, Y balance test and anthropometric outcomes were assessed. A correlation study and a regression model were performed to investigate the influence of such outcomes and the value of their participation on the hop test results.
Results
It was found a low-to-moderate correlation effect size for both countermovement jump (distance and power flight) and Y balance test values (except interlimb outcomes) with the single leg hop test results. Anthropometric outcomes did not show significant correlation (p > 0.05). Regression model revealed significant predictive value for countermovement jump outcomes in both right (β = 0.249, p = 0.013; β = 0.301; p = 0.031) and left leg (β = 0.229, p = 0.025; β = 0.365, p = 0.040), as well as certain Y balance outcomes values.
Conclusions
Among young elite female basket athletes, the explosive strength, measured with the countermovement jump, seems to be a relevant functional component for the results of the single leg hop test. Also, dynamic balance, but with a minor influence. Focusing on the elements that compose the hop test helps to improve the understanding and the design of specific interventions to enhance the test's performance.
Afterload Pressure and Left Ventricular Contractility Synergistically Affect Left Atrial Pressure During Veno-Arterial Extra-Corporeal Membrane Oxygenation
Authors: Jiang Jacky , Jain Pankaj , Adji Audrey , Stevens Michael , Vazquez Gabriel Matus , Barua Sumita , Hayward Christopher 
Published: December 2022

Abstract
Background: Veno-arterial extra-corporeal membrane oxygenation (VA-ECMO) may cause adverse effects including increased left ventricular (LV) filling pressure, LV distension and pulmonary oedema. We aimed to quantify the effects of ECMO flow, LV contractility, aortic pressure (AoP) and ECMO configuration on left atrial pressure (LAP) during VA-ECMO for cardiogenic shock in a mock circulatory loop (MCL).
Methods: An MCL simulated a normal state, LV failure, right ventricular failure and biventricular failure. The ECMO return cannula was placed in the femoral artery (retrograde flow) or ascending aorta (antegrade flow). ECMO flow was incrementally increased from 0 to 5L/min. LAP, mean AoP, ECMO flow and total cardiac output were measured at steady state.
Results: During VA-ECMO, LAP increased linearly with AoP, with the slope greater in the presence of LV impairment compared to preserved LV function. When AoP was held constant, as is the goal of therapy in clinical management, ECMO flow had no effect on LAP. In multivariable linear regression, AoP and LV contractility (p<0.001 for each) correlated independently with LAP, but ECMO flow did not. ECMO return flow direction had no effect on LAP.
Conclusion:AoP and LV contractility, but not circuit flow or direction, independently determine LAP under VA-ECMO support. By controlling each of these inputs, vasodilator and inotrope management may combine synergistically to prevent VA-ECMO-related complications.
TMEM88 is a protective gene in HCC and has the function of promotes immune escape
Authors: LIMAN ANDREW , Zhu Qian 
Published: December 2022

AbstractBackground Transmembrane protein 88 (TMEM88) is a cancer-related protein that acts as a cancer-promoting or cancer-inhibiting regulator in multiple tumor types. However, the exact role of TMEM88 in liver cancer is unclear. This study was designed to determine the expression of TMEM88 in liver cancer cells. Results TMEM88 expression was higher in liver cancer tissues than in corresponding normal tissues. TMEM88 expression in HCC (Hepatocellular Carcinoma) tissues correlates with prognosis. Low TMEM88 expression was associated with poorer overall survival, disease-specific survival, progression-free survival, and relapse-free survival in multiple cohorts of patients with HCC, particularly in late disease stages (grades 2 and 3). Furthermore, there was a positive correlation among MCPCOUNTER infiltration, XCELL infiltration and TIDE infiltration of TMEM88 in liver tumor cells. Conclusions These findings demonstrate that TMEM88 is a protective gene in HCC and promotes immune escape.
A novel symmetry analysis methodology for general energy conversion systems
Authors: Guo Huan , Xu Yujie , Li Yifu , Huang Lujing , Chen Haisheng 
Published: December 2022

Abstract
Symmetry has attracted extensive attention in the field of mathematics and physics. However, the previous studies of symmetry paid less attention to macroscopic system analysis. In this paper, the symmetry of macroscopic energy conversion systems/cycles is explored, and the symmetry analysis method is established for the first time. We found that general energy conversion systems/cycles show a certain symmetry after parameter transformations. Brayton cycle is analyzed as an example, and the potential-displacement-energy (PDE) diagram for system symmetry analysis is proposed. By establishing the specific C-P diagram (a kind of PDE diagram) to analyze the Brayton cycle, it is found that the ideal Brayton cycle has a regular symmetrical structure. When the rotational symmetry is the strongest, the maximum work is generated; and when the reflection symmetry is the strongest, the system is most efficient with constant specific heat capacity (cp). When the integral of varied cp to temperature can be decomposed into the symmetric structure of temperature along with the constraints met, cp has no effect on the intermediate maximum-work temperature, and this condition for cp is greatly broaden compared with previous literatures. Meanwhile, a more symmetrical cycle with circular-shaped structure is established with π/2 times greater of work output compared to conventional Brayton cycle, and the system efficiency is also improved due to its symmetry. By constructing the symmetrical structure, general energy conversion systems including P-V-T cycles can also be analyzed with the proposed symmetry analysis method.
Effects of Reminiscence Therapy combined with Memory Specificity Training (RT-MeST) on depressive symptoms in older adults: A Randomized Controlled Trial Protocol
Authors: Wu Yuejin , Zhang Xin , Yu Tianzhuo , Sui Xin , Li Yuewei , Xu Haiyan , zeng Ting , Leng Xin , Zhao Lijing , Li Feng 
Published: December 2022

Abstract
Background: Geriatric depression has become a serious public health problem, reduced autobiographical memory and increased over-general memory, as main cognitive markers of depression, are not only associated with current depressive symptoms but also associated with the onset and course of depression, which can lead to a range of harms, economic and effective psychological interventions are urgently needed. The aim of this study was to confirm the effectiveness of reminiscence therapy combined with memory specificity training in improving autobiographical memory and depressive symptoms in older adults.
Methods：In this multicenter, single-blind, three-arm parallel randomized controlled study, we aim to enroll 78 older adults aged 60 years or older with a score of ≥11 on the Geriatric Depression Scale, and participants will be randomly assigned to either the reminiscence therapy group or reminiscence therapy with memory specificity training group or usual care group. Assessments will be conducted at baseline (T0) as well as immediately post-intervention (T1), 1 (T2), 3 (T3) and 6 (T4) months post-intervention. The primary outcome measure is self-reported depressive symptoms, measured using the GDS. Secondary outcome measures included measures of autobiographical memory, rumination, and social engagement.
Discussion: We believe that the intervention has played a positive role in improving autobiographical memory and depressive symptoms in older adults. Poor autobiographical memory is a predictor of depression and a major cognitive marker，improving autobiographical memory is of great significance in alleviating depression symptoms in the elderly. If our program is effective, it will provide a convenient and feasible strategy for further promoting healthy aging.
Trial registration:ChiCTR2200065446
Fully automatic transfer and measurement system for structural superlubric materials
Authors: Chen Li , Lin Cong , Shi Diwei , Zheng Quanshui , Nie Jinhui , Ma Ming 
Published: December 2022

Abstract
Structural superlubricity (SSL), a state of nearly zero friction and no wear between two contact surfaces under relative sliding, holds immense potential for research and application prospects in the fields of MEMS devices, mechanical engineering, and energy resources. A critical step towards the practical application of SSL is the massive transfer and high throughput performance evaluation. As SSL systems are heterogeneous, existing automated systems, such as roll printing or massive stamping, are inadequate for this task. In this paper, a machine learning-assisted system is proposed to realize fully automated selective transfer and mechanical performance measurement for SSL materials. Specifically, the system has a judgment accuracy of over 98% for the selection of micro-scale graphite flakes with SSL properties. It can also complete the self-retraction force measurement of an individual graphite flake within 30 s, which is five times faster than manual operation. For fabrication, the system can complete the 10×10 graphite flakes assembly array and form various pre-designed patterns within 100 mins without manual intervention, which is 15 times faster than manual operation. The high accuracy, efficiency, robustness, and scalability of this automated system open up new possibilities in micron-scale experiments and manufacturing, and they pave the way for the construction of a database for the genetic engineering of micron materials.
Using inverse Mie calculations to extract size and refractive index of the non-absorbing particles from their polarized light back-scattering intensity measurements
Authors: kerma El-yazid , Ayadi Khaled , Ferria Kouider 
Published: December 2022

Abstract
In this paper, we presented the optical technical to extract size and refractive index of the non-absorbing particles. It is based on the inverse Mie for calculating the Mie scattering amplitudes S1 (θ) and S2 (θ) from their measurement of the electromagnetic backscattering linear polarized plane. In this case, we realized a simple experimental setup placed in our laboratory and it focused on three parameters: the incident angle (α), the polarizer (P) and the sample of sands. This optical technical showed the incident light interact with the irregular surface of sample, the polarized light is scattered in the serval backward directions in the space and the backward received signal is measured by a focusing onto a CCD capture in the two backward directions scanning with a 5° scattering setup angle. The experimental data of the polarized scattering intensities i1 (θ) and i2 (θ) was measured by our experimental setup, and they converted to the Mie scattering amplitudes S1 (θ) and S2 (θ). Hence, when those amplitudes are known the Mie coefficients an and bn can be obtained. Then we can extract the refractive index and the radius of the non-absorbing particles at the same time from the Mie coefficients. Then, the physico-chemical properties of the non-absorbing particles calculated and shown to be nearly identical to that of original particles compared with the old instruments. The presented technique is suggested for employing in optical instruments to characterize the nature of surfaces.
A 0.7-2.7 GHz Low Power LNA with Noise Cancellation and Current-Reused Technique
Authors: Baghini Sajjad Shojaei , TaheriNasab SeyedAli Samareh , Sheikhaei Samad 
Published: December 2022

Abstract
In this work, a low-power wideband low noise amplifier (LNA) is presented. The proposed LNA is designed based on CG-CS topology which is used for broadband applications. In addition, by adjusting the gm values of the CS stage transistors properly, an attempt has been made to cancel the noise of the CG stage. Moreover, by using the current-reused technique and placing an inductor in the middle node of cascode transistors in the CS stage, it is possible to reduce the impedance caused by the parasitic capacitors of the transistors, which enhance the power gain (S21). In addition, a gm-boosting technique is adopted to achieve better input impedance matching and reducing the current which pass through the CG stage. And finally, for better linearity results, sweet spot technique has been used to determine the bias voltage of transistors. The LNA has the maximum power gain (S21) of 18.6dB with a bandwidth of 0.7-2.7GHz, and noise figure of 2.95-3.4dB. It consumes 3.97mW of power from a 1.8V supply excluding testing buffer.
Sub-cell scale features govern the placement of new cells by honeybees during comb construction
Authors: Gallo Vincent , Bridges Alice D. , Woodgate Joseph L. , Chittka Lars 
Published: December 2022

Abstract
Honeybee comb architecture and the manner of its construction has long been the subject of scientific curiosity. Comb is characterised by an even hexagonal layout and the sharing of cell bases and side walls, which provides maximised storage volume while requiring minimal wax. The efficiency of this structure relies on a regular layout and the correct positioning of cells relative to each other, with each new cell placed at the junction of two previously constructed cells. This task is complicated by the incomplete nature of cells at the edge of comb, where new cells are to be built. We presented bees with wax stimuli comprising shallow depressions and protuberances in simulation of features found within partially formed comb, and demonstrated that construction work by honeybee builders was directed by these stimuli. The building of new cells was aligned to concave stimuli that simulated the clefts that naturally appear between two partially formed cells, revealing how new cells may be aligned to ensure proper tessellation within comb. We also found that bees built cell walls in response to edges formed by our stimuli, suggesting that cell and wall construction was specifically directed towards the locations necessary for continuation of hexagonal comb.
Soil moisture affects soil microbial community diversity, structure and phenotypic characteristics on the south shore of Hulun Lake in Inner Mongolia of China
Authors: Chen Xin , Wang Yujue , Shen Yuting , Sang Weiguo , Xiao Chunwang 
Published: December 2022

Abstract
Soil moisture is one important factor affecting ecosystem function, controlling the diffusion and transport of soil nutrients, maintaining soil microbial activities, and altering soil microbial diversity. To explore the response of soil microbial to soil moisture in the grassland ecosystem along the south shore of Hulun Lake in Inner Mongolia, China, we established a study area covering a natural soil moisture gradient which was subdivided into high (HW), medium (MW) and low water content (LW). Aboveground and belowground properties were measured by field investigation and laboratory analyses, respectively. Soil prokaryotic community composition was determined by high-throughput sequencing techniques. Soil moisture content as a dominant controlling factor, and soil organic nutrients as a secondary controlling factor, significantly affected the diversity of prokaryotic communities. The relative abundance and diversity of prokaryotic microbial were highest under MW, indicating a high heterogeneity of prokaryotes. However, the number of differential ASVs decreased, indicating that the structure and composition of the community stabilized under MW. Therefore, the prokaryotic community was more suitable to survive under MW. Although the relative abundance and diversity of microorganisms were lower under HW and LW than MW, phenotypic predictions showed that the prokaryotic community was more tolerant. We believe that either too high or too low soil water content will reduce the relative abundance and diversity of prokaryotic communities, and the communities will gradually become resistant to stress. Soil microbial community characteristics of the south shore of Hulun Lake in Inner Mongolia, China, respond significantly to soil moisture.
Genetic composition of high-quality strong gluten wheat varieties ‘Xinmai 26’ and ‘Xinmai 45’
Authors: Yang Li-Juan , Ma Jian , Zhang Da-Le , Yang Hai-Feng , Dong Yan-Qi , Qi Zeng-Jun , Wang Ze , Jiang Zhi-Kai , Ma Hua-Ping 
Published: December 2022

Abstract
The high quility has become an important goal of wheat breeding. Several super-strong gluten wheat varieties, e.g. ‘Xinmai 26’ and ‘Xinmai 45’, have been bred to meet consumer market. However, the genetic composition, transmission frequency and genetic contribution of them and their progeny are not clear. To analyze the genetic composition of the high-quality strong gluten wheat varieties ‘Xinmai 26’ and ‘Xinmai 45’, the genetic contribution rates of male and female parents to the varieties were analyzed using 6056 SNP markers detected by a widely used high-throughput wheat array (15K chip). Additionally, the chromosome polymorphisms of five related wheat varieties were determined by fluorescence in situ hybridization (FISH) using four oligonucleotide probe sets. The results showed that the genetic contribution rate of ‘Jinan 17’ against ‘Xinmai 26’ was 55.97%, much higher than the 15.81% of ‘Xinmai 18’. ‘Jimai 20’ showed a genetic contribution rate of 57.53% against ‘Xinmai 45’, which was slightly higher than that of ‘Xinmai 26’ at 40.21%. The specific fragment differences from male and female parents were identified in both breeding varieties, and ‘Xinmai 26’ had more specific fragments that differed from male and female parents than ‘Xinmai 45’. The chromosomes of group A and group B of the five varieties were significantly polymorphic, but no chromosomes translocations or inversions were found. The promising results would be helpful to explore the genetic pattern of high-quality varieties, promote breeding efficiency, and utilize the superior traits of backbone parents for wheat quality improvement.