bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid digital manufacturing: Capturing the value of digitalization
Authors: Stark Andreas , Ferm Kenneth , Hanson Robin , Johansson Mats , Khajavi Siavash , Medbo Lars , Öhman Mikael , Holmström Jan 
Published: December 2022

AbstractA chasm is growing between the advanced technologies available for improving manufacturing operations and those effectively used in practice. The vision of Industry 4.0 is to mobilize industry to seek out these possibilities for improvement and to close the gap between opportunity and reality. However, when compared with more established improvement opportunities such as lean manufacturing, the digitalization of manufacturing lacks in both paradigmatic examples and an understanding of how to achieve the benefits. This lack is a complication of concern: Without an appropriate operations strategy to capture the value of digitalization, manufacturing companies will be unable to focus on technological investments and operational changes. To address this concern, operations management academics must develop new theory through active engagement in the practice of digitalization in manufacturing. This research presents a paradigmatic example, based on engaged scholarship, focused on effectively combining novel object‐interactive and conventional manufacturing syntax for benefiting from digitalization in internal operations and the wider supply chain. The contribution to literature is a novel operations strategy—hybrid digital manufacturing—for capturing the value of Industry 4.0 technologies.
Modified celluloses improve the proofing performance and quality of bread made with a high content of resistant starch
Authors: Arp Carlos Gabriel , Correa María Jimena , Ferrero Cristina 
Published: December 2022

AbstractBACKGROUNDAdding resistant starch (RS) to bread formulations is a promising way of increasing fiber content of white bread. However, the partial replacement of wheat flour (WF) by RS can lead to a decrease in technological quality. The objective of this study was to analyze the performance of hydroxypropylmethylcellulose and carboxymethylcellulose as improvers of wheat bread with a high level of replacement (30%) with maize RS. The levels of the modified celluloses were 1% and 1.5% (WF + RS basis), and a formulation without modified celluloses was used as control. Proofing time, loaf volume, crumb characteristics (porosity, texture), and bread staling parameters (hardness increase, moisture loss), among other attributes, were analyzed, and principal component analysis was applied to compare samples.RESULTSThe use of both modified celluloses was effective in improving the quality of breads. Specific volume and crumb porosity were enhanced, particularly at the 1.5% level. Breads with modified celluloses also allowed a higher retention of water and a better preservation of mechanical properties during storage. The principal component analysis projection graph for the first two principal components showed that samples with modified celluloses were clustered by the level of hydrocolloid addition rather than by the type of hydrocolloid used, although all the samples with modified celluloses were close to each other and distant from the control sample without hydrocolloids.CONCLUSIONThe quality decrease resulting from the replacement of WF by a high level of RS can be greatly compensated by the use of structuring agents such as hydroxypropylmethylcellulose and carboxymethylcellulose. © 2022 Society of Chemical Industry.
Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide‐treated mice
Authors: Tian Baoming , Liu Renjian , Xu Tianrui , Cai Ming , Mao Rongliang , Huang Liangshui , Yang Kai , Zeng Xiaoxiong , Peilong Sun 
Published: December 2022

AbstractBACKGROUNDThe gut microbiota (GM) is recognized as a significant contributor to the immune system. In the present study, the effects of Hericium erinaceus polysaccharides (HEP) on immunoregulation and GM in cyclophosphamide (CTX)‐treated mice were investigated to elucidate the attenuate of immunosuppression by modulating GM.RESULTSThe results revealed that HEP significantly improved the body weight and immune organ index in immunodeficient mice (P < 0.05). They significantly increased operational taxonomic units (OTUs) (P < 0.05), adjusted the α and β diversity of the GM, and the bacterial community structure was more similar to that of control group. Taxonomic composition analysis found that HEP increased the abundance of Alistipse, uncultured_bacterium_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, uncultured_bacterium_f_Lachnospiracea, uncultured_bacterium_f_Ruminococcaceae and Ruminococcaceae_UCG‐014, and decreased Lactobacillus, Bacteroides, and Alloprevotella, suggesting that HEP can improve the GM structure and inhibit CTX‐induced GM dysregulation. Moreover, HEP increased short‐chain fatty acid (SCFA)‐producing bacteria, recovered SCFA levels, alleviated immunosuppression caused by CTX, enhanced the serum immune cytokine factors, and upregulated TLR4/NF‐κB pathway key proteins (TLR4, NF‐κB p65) at mRNA and protein levels.CONCLUSIONHericium erinaceus polysaccharides effectively regulated GM and enhancement of intestinal immune function, so they have the potential to be developed as functional ingredients or foods to modulate immune responses. © 2022 Society of Chemical Industry.
Microfiber Fabricated via Microfluidic Spinning toward Tissue Engineering Applications
Authors: Tian Lingling , Ma Jingyun , Li Wei , Zhang Xu , Gao Xinghua 
Published: December 2022

AbstractMicrofibers, a type of long, thin, and flexible material, can be assembled into functional 3D structures by folding, binding, and weaving. As a novel spinning method, combining microfluidic technology and wet spinning, microfluidic spinning technology can precisely control the size, morphology, structure, and composition of the microfibers. Particularly, the process is mild and rapid, which is suitable for preparing microfibers using biocompatible materials and without affecting the viability of cells encapsulated. Furthermore, owing to the controllability of microfluidic spinning, microfibers with well‐defined structures (such as hollow structures) will contribute to the exchange of nutrients or guide cell orientation. Thus, this method is often used to fabricate microfibers as cell scaffolds for cell encapsulation or adhesion and can be further applied to biomimetic fibrous tissues. In this review, the focus is on different fiber structures prepared by microfluidic spinning technology, including solid, hollow, and heterogeneous structures, generated from three essential elements: spinning platform, fiber composition, and solidification methods. Furthermore, the application of microfibers is described with different structures in tissue engineering, such as blood vessels, skeletal muscle, bone, nerves, and lung bronchi. Finally, the challenges and future development prospects of microfluidic spinning technology in tissue engineering applications are discussed.
Tuning Human Serum Albumin (HSA) Hydrogels through Albumin Glycation
Authors: Volmer Jonas , Arabi S. Hamidreza , Henning Christian , Glomb Marcus A. , Hinderberger Dariush 
Published: December 2022

AbstractThe changes of technological properties of albumin‐based hydrogels induced by increasing degrees of post‐translational modification of the protein are reported. Maillard‐type modification of amino acids arginine and lysine of albumin is achieved through glyoxal as an α‐dicarbonyl compound. The degrees of modification are fine‐tuned using different molar ratios of glyoxal. Hydrogels are thermally induced by heating highly concentrated precursor solutions above the protein's denaturation temperature. While the post‐translational modifications are determined and quantified with mass spectrometry, continuous‐wave (CW) electron paramagnetic resonance (EPR) spectroscopy shed light on the protein fatty acid binding capacity and changes thereof in solution and in the gel state. The viscoelastic behavior is characterized as a measure of the physical strength of the hydrogels. On the nanoscopic level, the modified albumins in low concentration solution reveal lower binding capacities with increasing degrees of modification. On the contrary, in the gel state, the binding capacity remains constant at all degrees of modifications. This indicates that the loss of fatty acid binding capacity for individual albumin molecules is partially compensated by new binding sites in the gel state, potentially formed by modified amino acids. Such, albumin glycation offers a fine‐tuning method of technological and nanoscopic properties of these gels.
Effect of Test Parameters on Tribological and Hardness Properties of UHMWPE/Reduced Graphene Oxide Nanocomposites
Authors: Soares Pedro Henrique Vilela , Amurin Leice Gonçalves , da Silva Aline Bruna 
Published: December 2022

AbstractUltra‐high molecular weight polyethylene (UHMWPE) exhibits high wear resistance, low coefficient of friction (COF), and high impact strength. The operating conditions can influence the performance of the UHMWPE in specific applications. Graphene is applied as reinforcement to the UHMWPE matrix in order to improve the tribological and mechanical properties. In the present work, the effects of the test parameters on the hardness and tribological behavior of nanocomposites are evaluated. The Vickers microhardness of the UHMWPE/rGO nanocomposites increases by up to 25% at 0.50 wt% of rGO, regardless of the indentation applied load. Pin‐on‐disc tests are performed for the polymer at several sliding speeds and applied normal loads to get information about friction responses. Once the most suitable parameters have been defined, the pin‐on‐disc tests of the UHMWPE/rGO nanocomposites are performed, resulting in a decrease of up to 48% of the COF at 0.25 wt% of rGO.
Mechanical Properties of PLA/PCL Blends Compatibilized with PEG‐b‐PCL Multiblock Copolymer
Authors: Staffa Lucas H. , Bettini Sílvia H. P. , Chinelatto Marcelo A. 
Published: December 2022

AbstractAmong the various kinds of copolymers that can be used as compatibilizers in poly (lactic acid) (PLA) and poly(ε‐caprolactone) (PCL) blends, copolymers containing segments of ε‐caprolactone and ethylene glycol (PEG) are an interesting choice because they are also biodegradable and biocompatible. A multiblock copolymer containing PEG and PCL segments, synthesized via one‐step bulk polycondensation, is added into PLA/PCL blend (80/20 wt%) at 1 and 5 wt% from the molten state, using a twin‐screw extruder. The effect of the PEG‐b‐PCL copolymer on the mechanical properties of PLA/PCL blends is investigated by tensile and Izod impact tests. The mixing of PCL with PLA does not promote adequate matrix toughness due to the incompatibility between the phases. The addition of only 1 wt% of the multiblock copolymer little changes the mechanical behavior of the blend. Only the compatibilized PLA/PCL blend with 5 wt% of the multiblock copolymer exhibits a significant increase in strain at break and notches Izod impact resistance in comparison with uncompatibilized PLA/PCL blends or neat PLA. Therefore, the addition of the PEG‐b‐PCL multiblock copolymer results in a marked change in the mechanical behavior, from brittle to ductile at room temperature, and confirms its compatibilization potential for the PLA/PCL immiscible blends.
Effect of Vulcanization System on Damping Properties of Natural Rubber
Authors: Baruel Amanda Faria , de Mello Sandra Aparecida Coelho , Menezes Fernanda , Cassu Silvana Navarro 
Published: December 2022

AbstractNatural rubber (NR) is vulcanized with three different systems, using sulfur, peroxide and a mixed system consisting of peroxide and sulfur. The viscoelastic behavior of rubbers is evaluated by Dynamic Mechanical Analysis (DMA), using constant or multiple frequencies. From both DMA analysis methods, it is possible to verify that the rubbers vulcanized with sulfur or with the mixed system presented superior storage modulus in the rubbery region, and higher Tg values compared to the rubber vulcanized with dicumyl peroxide. These results indicate a higher degree of crosslinking for the NR containing sulfur in its vulcanization system. The master curves show that the rubber vulcanized with sulfur presented relaxation at a lower frequency due to the higher hardness, which is a consequence of the higher degree of crosslinking.
Reduced D2/D3 Receptor Binding and Glucose Metabolism in a Macaque Model of Huntington's Disease
Authors: Weiss Alison R. , Bertoglio Daniele , Liguore William A. , Brandon Kristin , Templon John , Link Jeanne , McBride Jodi L. 
Published: December 2022

AbstractBackgroundDopamine system dysfunction and altered glucose metabolism are implicated in Huntington's disease (HD), a neurological disease caused by mutant huntingtin (mHTT) expression.ObjectiveThe aim was to characterize alterations in cerebral dopamine D2/D3 receptor density and glucose utilization in a newly developed AAV‐mediated NHP model of HD that expresses mHTT throughout numerous brain regions.MethodsPositron emission tomography (PET) imaging was performed using [18F]fallypride to quantify D2/D3 receptor density and 2‐[18F]fluoro‐2‐deoxy‐d‐glucose ([18F]FDG) to measure cerebral glucose utilization in these HD macaques.ResultsCompared to controls, HD macaques showed significantly reduced dopamine D2/D3 receptor densities in basal ganglia (P < 0.05). In addition, HD macaques displayed significant glucose hypometabolism throughout the cortico‐basal ganglia network (P < 0.05).Conclusions[18F]Fallypride and [18F]FDG are PET imaging biomarkers of mHTT‐mediated disease progression that can be used as noninvasive outcome measures in future therapeutic studies with this AAV‐mediated HD macaque model. © 2022 International Parkinson and Movement Disorder Society.
Numerical prediction on the photovoltaic performance of CZTS‐based thin film solar cell
Authors: Abir Ahnaf Tahmid , Joy Arifuzzaman , Mondal Bipanko Kumar , Hossain Jaker 
Published: December 2022

AbstractThis article presents an enormously effective Cu2ZnSnS4 (CZTS)‐based n‐ZnS/p‐CZTS/p+‐WSe2 thin film solar cell. The device has been studied by varying the thickness, doping concentration and defect density of each layer utilizing SCAPS‐1D simulation software. The power conversion efficiency (PCE) for n‐ZnS/p‐CZTS single heterojunction is 14.06% with the JSC = 20.26 mA cm−2, VOC = 0.88 V and FF = 78.59%, respectively. This PCE is elevated to 27.31% with the JSC = 33.72 mA cm−2, VOC = 0.97 V and FF = 83.75%, respectively due to insertion of WSe2 back surface field (BSF) layer in the same structure. The significant improvement of PCE mainly depends on short circuit current which is resulted due to WSe2 layer that absorbs sub‐band gap photons through tail‐states‐assisted (TSA) photon upconversion method. These entire results demonstrate the potential of WSe2 as BSF layer in CZTS‐based thin film solar cells.
Multi‐objective optimization‐based robust fault estimation observer design for fuzzy singularly perturbed systems with time‐varying state delays
Authors: Zeng Qiuyuan , Sun Chao , Huang Shengjuan , Yi Suhuan 
Published: December 2022

SummaryIn this paper, the problem of multi‐objective robust fault estimation based on observer is addressed for T‐S fuzzy nonlinear singularly perturbed systems with time‐varying state delay and external disturbance. Under performance constraint, a fuzzy augmented fault estimation observer is introduced to improve the performance of actuator and sensor fault estimation simultaneously. The sufficient conditions for the existence of fault estimator are given in the form of LMIs, where ‐dependent Lyapunov function is considered. The given multi‐objective fault estimator design strategy has a good ability to suppress external disturbance and ensure the estimation accuracy and convergence rate work well for all . Then the largest stability bound and the best attenuation capacity are guaranteed by deriving a modified optimal algorithm. Finally, two examples are given to illustrate the feasibility and correctness of the proposed design method.
Loss of protective anti‐HBs titers and seroconversion to hepatitis B vaccination in children during chemotherapy for acute lymphoblastic leukemia
Authors: Rajendran Prasanth Varikkattu , Thankamony Priyakumari , Rajeswari Binitha , Sojamani Guruprasad Chellapan , Nair Manjusha , Parukuttyamma Kusumakumary , Krishna KM Jagathnath 
Published: December 2022

AbstractBackgroundThis study aimed to evaluate loss of protective anti‐hepatitis B (HBs) titers and seroconversion to hepatitis B vaccine (HBV) during chemotherapy in children with acute lymphoblastic leukemia (ALL).MethodsAnti‐HBs titers were done at diagnosis. Patients were divided into two groups. Group I (protective titers >10 mIU/ml) received single double dose of HBV as booster. Titers were repeated at three time points: end of phase 1b, beginning of re‐induction, and start of maintenance chemotherapy. Group II (nonprotective titers <10 mIU/L) received hepatitis B immunoglobulin (HBIG), prior to start of chemotherapy, followed by three double doses of HBV as booster. Titers were repeated at two time points: prior to first dose, and 4 weeks after third dose of vaccine.ResultsTotal 125 patients were included: 88 in group I; 37 in group II. Among group I patients, 98.7%, 90%, and 84% retained protective titers at the three points, respectively. Subgroup analysis showed that those with initial titers greater than 100 mIU/L retained protective titers better than those with titers between 11 and 100 mIU/L (p = .0001). Among group II patients, 62% and 64% attained protective titers at the two points, respectively.ConclusionsHBV boosters helped maintain protective titers during intensive ALL chemotherapy in immunized children having titers more than 10 mIU/L, and more so if titer was more than 100 mIU/L. Therefore, we propose that cut off for protective anti‐HBs titers be changed to greater than or equal to 100 mIU/L. Titers between 11 and 100 mIU/L may require combined active and passive immunization. Around one‐third of group II patients who fail to attain protective titers may need frequent doses of HBIG.
The varied spectrum of nephroblastomatosis, nephrogenic rests, and Wilms tumors: Review of current definitions and challenges of the field
Authors: Fialkowski Elizabeth , Sudour‐Bonnange Hélène , Vujanic Gordan M. , Shamberger Robert C. , Chowdhury Tanzina , Aldrink Jennifer H. , Davick Jonathan , Sandberg Jesse , Furtwaengler Rhoikos , Mullen Elizabeth 
Published: December 2022

AbstractThe diagnosis of multiple or diffuse renal lesions in a child is challenging by imaging and/or pathology. Optimal management requires distinguishing benign lesions such as nephrogenic rests from cancerous lesions such as Wilms tumor, but this is often difficult or impossible. This difficulty is compounded by the overlapping nature of our current radiologic and pathologic definitions of lesions along the spectrum of nephrogenic rests/nephroblastomatosis. We provide a review of these issues, as a collaborative effort between the Children's Oncology Group Renal Tumor Committee and International Society of Pediatric Oncology Renal Tumor Study Group. Our aim is to discuss current challenges in diagnosis and management of these renal lesions, encouraging future work toward consensus definitions for research and patient care.
Automated Quantification of 3D Wound Morphology by Machine Learning and Optical Coherence Tomography in Type 2 Diabetes
Authors: Wang Yinhai , Freeman Adrian , Ajjan Ramzi , Del Galdo Francesco , Tiganescu Ana 
Published: December 2022

Abstract

Background
Driven by increased prevalence of type 2 diabetes and ageing populations, wounds affect millions of people each year, but monitoring and treatment remain limited. Glucocorticoid (stress hormones) activation by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) also impairs healing. We recently reported that 11β-HSD1 inhibition with oral AZD4017 improves acute wound healing by manual 2D optical coherence tomography (OCT), although this method is subjective and labour-intensive.

Objectives
Here, we aimed to develop an automated method of 3D OCT for rapid identification and quantification of multiple wound morphologies.

Methods
We analysed 204 3D OCT scans of 3 mm punch biopsies representing 24 480 2D wound image frames. A u-net method was used for image segmentation into 4 key wound morphologies: early granulation tissue, late granulation tissue, neo-epidermis, and blood clot. U-net training was conducted with 0.2% of available frames, with a mini-batch accuracy of 86%. The trained model was applied to compare segment area (per frame) and volume (per scan) at days 2 and 7 post-wounding and in AZD4017 compared to placebo.

Results
Automated OCT distinguished wound tissue morphologies, quantifying their volumetric transition during healing, and correlating with corresponding manual measurements. Further, AZD4017 improved epidermal re-epithelialisation (by manual OCT) with a corresponding trend towards increased neo-epidermis volume (by automated OCT).

Conclusion
Machine learning and OCT can quantify wound healing for automated, non-invasive monitoring in real-time. This sensitive and reproducible new approach offers a step-change in wound healing research, paving the way for further development in chronic wounds.
Effect of Hollow Glass Microspheres with Different Contents and Types on Properties of Polypropylene Composites
Authors: Zhu Zhaolin , Wang Jinxiang , Liu Yin , Xian Guiyang , Wang Yan , Wu Chongmei , Peng Xiaobo , Fang Yongwei , Kong Ling Bing 
Published: December 2022

AbstractIn this paper, hollow glass microspheres (HGM) reinforced polypropylene (PP) composites were prepared. The effects of the type and content of HGM on the mechanical properties of the composite materials were investigated. It is found that the introduction of HGM leads to a decrease in the density of the composites, where the smallest density is 0.85 g cm−3. The tensile, bending, and impact strengths of the HGM/PP composites are slightly lower than those of pure PP resin. For a given type of HGM, as the filler content increases, the tensile properties of the HGM/PP composite decrease. A similar trend is observed in the impact strength, however, it is not observed in the bending performance. The mechanical properties of the HGM/PP composites are not only affected by the density of HGM fillers, but also by its content. The maximum bending modulus of the composites could be 24 % higher than that of the pure PP resins. In addition, the PP sample with HGM modified with γ‐aminopropyl triethoxysilane (KH550) showed promising interfacial bonding strength.
Three‐Dimensional Graphene Network Decorated with Bimetallic Cerium/Copper Oxide Nanoparticles for Non‐Enzymatic Diagnosis of Phenylketonuria
Authors: Rezaie Maryam , Nemati Fatemeh , Firoozbakhtian Ali , Tabesh Hadi , Ganjali Mohammad Reza , Hosseini Morteza 
Published: December 2022

AbstractExceptional sensitivity and user‐friendly operation of electrochemical sensors have made them a potential promise in diagnosing, monitoring, and treating Phenylketonuria (PKU). A three‐dimensional graphene matrix decorated with cerium and copper oxide particles was synthesized by a one‐pot hydrothermal technique. Because of several functional groups and active sites on the graphene composite, the fabricated sensor is able to detect PKU based on the non‐enzymatic sensing strategy. The bimetallic composite with excellent electrocatalyst activity accelerates the electrooxidation of phenylalanine. The as‐fabricated enzyme‐free sensor exhibited a wide linearity toward concentration of L‐phenylalanine (L‐Phe), from 50 to 8000 μm with R2=0.9935 and a detection limit of 12 μm (S/N=3). The experiments have been completed towards determining the L‐Phe concentrations in human serum with the recovery of 96 % and 105 %.