bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Thermally Chargeable Supercapacitor based on the g‐C3N4‐Doped PAMPS/PAA Hydrogel Solid Electrolyte and 2D MOF@Ti3C2Tx MXene Heterostructure Composite Electrode
Authors: Du Zhijian , Liu Weijia , Liu Jinhai , Chu Zhengyu , Qu Fengyu , Li La , Shen Guozhen 
Published: April 2023

AbstractWith the development of individual wearable electronics, the requirements of self‐energy harvest devices from human skin or motion have increased. A thermal harvest device that receives thermal energy naturally existed in human skin is more attractive than a mechanical energy harvester that needs human motion or walking. Herein, a thermal‐chargeable supercapacitor (TCSC) is proposed, which can convert thermal energy into electrical energy and then store the energy only by occurring the temperature difference between the two ends of the TCSC. The all‐solid‐state g‐C3N4‐modified hydrogel electrolyte in the TCSC provides more free protons and energy for proton migration by the electrostatic interaction and hydrogen bond interaction between g‐C3N4 and the acid group. The 2D MOF@Ti3C2Tx MXene heterojunction electrodes with the advantages of large pore size, adjustable and abundant REDOX sites of MOFs, and high conductivity of Ti3C2Tx MXene also ensure the high performance of the TCSC. As a result, the assembled TCSC exhibits excellent ionic thermal‐voltage (55.68 mV), Seebeck coefficient (18.56 mV K−1), and energy exchange efficiency (3.4%) upon a temperature difference of 3 K, and successfully drives the pressure sensor work.
TBX2‐WNT3A Axis Mediates the Development of Colorectal Cancer In Vitro and In Vivo
Authors: Zhou Yan , Dong Mingjie , Li Xiujuan 
Published: April 2023

AbstractThis study is designed to explore the roles of the T‐Box transcription factor 2 (TBX2)‐Wnt family member 3A (WNT3A) axis in colorectal cancer. Clinical specimens are collected from the colorectal cancer patients and the volunteers. TBX2 overexpression and knockout stable cell lines and WNT3A knockdown cells are constructed. The xenograft animal model is established by using those stable cell lines. Cell proliferation, migration, and invasion are evaluated. Quantitative reverse transcription polymerase chain reaction and Western blotting are used to determine the expression levels of target biomarkers. ChIP analysis is utilized to assess the enrichment of TBX2 on the promoter site of WNT3A. An elevation of TBX2 is observed in colorectal cancer specimens and TBX2 expression is positively correlated to cell proliferation, migration, and invasion. Besides, TBX2 regulates the expressions of biomarkers relevant to epithelial‐mesenchymal transition (EMT) and WNT3A signaling pathways. Interestingly, WNT3A also promotes the HCT116 cell proliferation, migration, invasion by the regulation of EMT‐related biomarkers. The in vivo study shows that the TBX2‐WNT3A axis promotes tumor growth. TBX2‐WNT3A axis promotes the development of colorectal cancer.
METTL3 Mediates Epithelial–Mesenchymal Transition by Modulating FOXO1 mRNA N6‐Methyladenosine‐Dependent YTHDF2 Binding: A Novel Mechanism of Radiation‐Induced Lung Injury
Authors: Feng Yang , Yuan Ping , Guo Hongjuan , Gu Liming , Yang Zhao , Wang Jian , Zhu Wei , Zhang Qi , Cao Jianping , Wang Lili , Jiao Yang 
Published: April 2023

AbstractThe biological roles of epithelial–mesenchymal transition (EMT) in the pathogenesis of radiation‐induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated. N6‐methyladenosine (m6A) modification, the most abundant reversible methylation modification in eukaryotic mRNAs, plays vital roles in multiple biological processes. Whether and how m6A modification participates in ionizing radiation (IR)‐induced EMT and RILI remain unclear. Here, significantly increased m6A levels upon IR‐induced EMT are detected both in vivo and in vitro. Furthermore, upregulated methyltransferase‐like 3 (METTL3) expression and downregulated α‐ketoglutarate‐dependent dioxygenase AlkB homolog 5 (ALKBH5) expression are detected. In addition, blocking METTL3‐mediated m6A modification suppresses IR‐induced EMT both in vivo and in vitro. Mechanistically, forkhead box O1 (FOXO1) is identified as a key target of METTL3 by a methylated RNA immunoprecipitation (MeRIP) assay. FOXO1 expression is downregulated by METTL3‐mediated mRNA m6A modification in a YTH‐domain family 2 (YTHDF2)‐dependent manner, which subsequently activates the AKT and ERK signaling pathways. Overall, the present study shows that IR‐responsive METTL3 is involved in IR‐induced EMT, probably by activating the AKT and ERK signaling pathways via YTHDF2‐dependent FOXO1 m6A modification, which may be a novel mechanism involved in the occurrence and development of RILI.
Integrating multiple soil management practices: A system‐wide approach for restoring degraded soil and improvingBrachiariaproductivity
Authors: Gutema Tekalegn , Kebede Erana , Legesse Hirpa , Fite Tarekegn 
Published: April 2023

AbstractLand degradation has severely affected soil health and agricultural productivity in the Sasiga district of western Oromiya, Ethiopia, demanding urgent and extensive solutions. Integrated soil management in particular is a comprehensive approach that could mitigate the multifaceted effects of land degradation. Hence, a field experiment was conducted on degraded farmers’ land to assess the potential of lime, organic amendments, tillage, and soil–water conservation (SWC) in improving the productivity of soil andBrachiaria(Mulato II). The experiment employed 15 treatments, which were systematically formulated from lime, organic amendments (compost and cattle manure), the SWC method (constructed soil bunds and no soil bunds), and tillage practices (ploughing and no‐ploughing). The study showed that applying lime with tillage or both tillage and SWC and organic amendments alone improved soil pH from very strongly acidic to moderately acidic. The combined application of lime, SWC, and tillage also enhanced the organic carbon, organic matter, total nitrogen, and moisture contents of the soil. Besides, the integrated use of cattle manure, SWC, and tillage practices boosted plant cover, tillering, plant height (PH), and dry biomass ofBrachiaria(Mulato II). Consequently, the physicochemical properties of the degraded soil and the agronomic performance ofBrachiariacan be improved by amending with combinations of lime or cattle manure with SWC and tillage. In general, integrating multiple soil management practices, including lime, organic amendments, SWC, and tillage, offers a whole‐system approach to rehabilitating degraded soil and improving its physicochemical properties and productivity ofBrachiariagrass.
Thirteen‐year stover harvest and tillage effects on soil compaction in Iowa
Authors: Phillips Claire L. , Tekeste Mehari Z. , Ebrahimi Elnaz , Logsdon Sally D. , Malone Robert W. , O'Brien Peter L. , Emmett Bryan D. , Karlen Douglas 
Published: April 2023

AbstractCorn (Zea mays L.) stover is an abundant biomass source with multiple end‐uses including cellulosic biofuel production. However, stover removal may increase soil compaction by reducing organic matter inputs and increasing vehicle loads during harvest. While numerous studies have reported stover removal impacts on soil physical quality, few have assessed the role played by traffic compaction. Our objective was to quantify subsurface soil compaction after 13 years of chisel plow versus no‐till management and no, moderate (3.5 ± 1.1 Mg ha−1 year−1), or high (5.0 ± 1.7 Mg ha−1 year−1) stover harvest rates. Penetration resistance was measured in most‐ and least‐trafficked interrow spaces. Chisel plowed plots with moderate and high levels of stover removal had higher penetration resistance in trafficked areas relative to least‐trafficked areas, whereas there was no evidence of traffic compaction when stover was retained. Traffic compaction did not negatively impact yields, which were greater with high levels of stover removal compared to no removal. The no‐till practice led to very small increases in penetration resistance with wheel traffic and had no evidence of increased compaction with residue removal. This lack of traffic compaction indicated soils under no‐till practice have a higher load‐bearing capacity than soils under chisel plow practice. Overall, there were no yield‐limiting effects of tillage practice or stover removal, and no evidence of soil compaction below the plow layer, suggesting stover removal with both tillage practices can be effectively employed without detrimental effects on plant or soil health.
Caregivers' concerns and supports needed to care for adults with Down syndrome
Authors: De La Garza Erica , Scott Ashley , Hillerstrom Hampus , Hendrix James , Rubenstein Eric 
Published: April 2023

AbstractResearch regarding caregivers for individuals with Down syndrome mainly focuses on outcomes for the pediatric population and not on the experience of caregivers themselves. Our objective was to understand caregiver‐reported experiences and concerns for themselves and the individual they care for through a survey of caregivers of adults with Down syndrome. We conducted a survey of N = 438 caregivers of adults with Down syndrome and asked about the perspectives of the respondents surrounding caregiving and demographics. The most common concerns among caregivers were planning for future needs (72.1%) and what happens when they (the caregiver) are gone (68.3%). Concerns they had for the individual they cared for were employment (63.2%) and friendships/relationships (63.2%). We found no significant difference in responses based on caregiver education level. Our survey identified six themes for the feedback about what clinical and research professionals should know to better serve individuals with Down syndrome, their families, and those who support them. Many caregivers discussed topics including healthcare, coordination, competence, and ability. More efforts for research into the caregiver experience for adults with Down syndrome are needed.
Hybrid Monomer Design Synergizing Property Trade‐offs in Developing Polymers for Circularity and Performance
Authors: Shi Changxia , Reilly Liam T. , Chen Eugene Y.‐X. 
Published: April 2023

AbstractCurrent search for more sustainable plastics seeks to redesign polymers possessing both chemical recyclability to monomer for a circular plastics economy and desirable performance that can rival or even exceed today's non‐recyclable or hard‐to‐recycle petroleum‐based incumbents. However, within a traditional monomer framework it is challenging to optimize, concurrently, contrasting polymerizability/depolymerizability and recyclability/performance properties. Here, we highlight the emerging hybrid monomer design strategy to develop intrinsically circular polymers with tunable performance properties, aiming to unify desired, but otherwise conflicting, properties in a single monomer. Conceptually, this design hybridizes parent monomer pairs of contrasting, mismatching, or matching properties into offspring monomers that not only unify the above‐described conflicting properties but also radically alter the resultant polymer properties far beyond the limits of what either parent homopolymers or their copolymers can achieve.
Spiroligomer‐Based Macrocycles for Atomically Precise Membranes
Authors: Xie Yihui , Luo Danni , Wiener Jesse A. , Koval Alexander B. , Pfeiffer Conrad T. , Schafmeister Christian E. 
Published: April 2023

AbstractHere, we report a new class of peptidomimetic macrocycles with well‐defined three‐dimensional structures and low conformational flexibility. They are assembled from fused‐ring spiro‐ladder oligomers (spiroligomers) by modular solid‐phase synthesis. Two‐dimensional nuclear magnetic resonance confirms their shape persistency. Triangular macrocycles of tunable sizes assemble into membranes with atomically precise pores, which exhibit size and shape‐dependent molecular sieving towards a series of structurally similar compounds. The exceptional structural diversity and stability of spiroligomer‐based macrocycles will be explored for more applications.
Unveiling the CO Oxidation Mechanism over a Molecularly Defined Copper Single‐Atom Catalyst Supported on a Metal–Organic Framework
Authors: Abdel‐Mageed Ali M. , Rungtaweevoranit Bunyarat , Impeng Sarawoot , Bansmann Joachim , Rabeah Jabor , Chen Shilong , Häring Thomas , Namuangrak Supawadee , Faungnawakij Kajornsak , Brückner Angelika , Behm R. Jürgen 
Published: April 2023

AbstractElucidating the reaction mechanism in heterogeneous catalysis is critically important for catalyst development, yet remains challenging because of the often unclear nature of the active sites. Using a molecularly defined copper single‐atom catalyst supported by a UiO‐66 metal–organic framework (Cu/UiO‐66) allows a detailed mechanistic elucidation of the CO oxidation reaction. Based on a combination of in situ/operando spectroscopies, kinetic measurements including kinetic isotope effects, and density‐functional‐theory‐based calculations, we identified the active site, reaction intermediates, and transition states of the dominant reaction cycle as well as the changes in oxidation/spin state during reaction. The reaction involves the continuous reactive dissociation of adsorbed O2, by reaction of O2,ad with COad, leading to the formation of an O atom connecting the Cu center with a neighboring Zr4+ ion as the rate limiting step. This is removed in a second activated step.
Monitoring the Progression of Early Atherosclerosis Using a Fluorescence Nanoprobe for the Detection and Imaging of Phosphorylation and Glucose Levels
Authors: Wen Ning , Li Jin , Zhang Wei , Li Ping , Yin Xia , Zhang Wen , Wang Hui , Tang Bo 
Published: April 2023

AbstractMonitoring the early stage of atherosclerosis (AS) without plaque formation is of great significance. Herein, we developed a metal organic framework (MOF)‐based fluorescence nanoprobe to analyze the progression of AS by assessing the levels of protein phosphorylation and glucose in blood and tissue. The probe was prepared by post‐modification of the MOF with iodine (I3−)‐rhodamine B (RhB) associate, which realizes the specific recognition of target object through the metal joint ZrIV and I3−‐RhB, respectively. We investigated different stages of target object changes in the early non‐plaque stage of AS in blood. It was found that the levels of phosphate and glucose in the blood were higher than those of the normal mice. The results of two‐photon images showed that early AS mice had higher levels of protein phosphorylation and glucose than that of the normal mice. The present study provides a suitable fluorescence tool for further revealing the pathogenesis and progression of AS.
Activatable NIR‐II Photothermal Lipid Nanoparticles for Improved Messenger RNA Delivery
Authors: Li Benhao , Zhao Mengyao , Lai Weiping , Zhang Xuanbo , Yang Bowei , Chen Xiaoyuan , Ni Qianqian 
Published: April 2023

AbstractEndosomal escape remains a central issue limiting the high protein expression of mRNA therapeutics. Here, we present second near‐infrared (NIR‐II) lipid nanoparticles (LNPs) containing pH activatable NIR‐II dye conjugated lipid (Cy‐lipid) for potentiating mRNA delivery efficiency via a stimulus‐responsive photothermal‐promoted endosomal escape delivery (SPEED) strategy. In acidic endosomal microenvironment, Cy‐lipid is protonated and turns on NIR‐II absorption for light‐to‐heat transduction mediated by 1064 nm laser irradiation. Then, the heat‐promoted LNPs morphology change triggers rapid escape of NIR‐II LNPs from the endosome, allowing about 3‐fold enhancement of enhanced green fluorescent protein (eGFP) encoding mRNA translation capacity compared to the NIR‐II light free group. In addition, the bioluminescence intensity induced by delivered luciferase encoding mRNA in the mouse liver region shows positive correlation with incremental radiation dose, indicating the validity of the SPEED strategy.
Time‐dependent mixed convection of Prandtl–Eyring hybrid nanofluid flow over a vertical cone: Entropy analysis
Authors: Patil Prabhugouda M , Goudar Bharath 
Published: April 2023

AbstractThe current work is motivated by the rising applications of non‐Newtonian hybrid nanofluids and entropy optimization in large‐scale industries. The Prandtl–Eyring nanofluid model, one of the numerous non‐Newtonian fluid models, is developed using molecular theory rather than empirical formulas. This study investigates the mixed convection flow of Prandtl–Eyring nanofluids from a vertical conical surface. This problem's governing equations are highly nonlinear and linked. Mangler's nonsimilar transformations were used to obtain a nondimensional representation of the governing equations. The obtained equations were linearized and discretized using Quasilinearization and the implicit finite difference method. This study concludes that, compared to Newtonian fluids, Prandtl–Eyring fluids have reduced surface friction
and fluid velocity. When comparing the Prandtl–Eyring hybrid nanofluid to the Newtonian hybrid nanofluid, we find that the latter improves energy transmission
by about 11%. With the Prandtl–Eyring hybrid nanofluid model instead of the standard Newtonian model, entropy generation (EG) can be reduced. Energy transport efficiency is improved by changing the nanoparticles shape from spherical to lamina. Concisely at
, the
and
boosted approximately by 29% and 17%, respectively, when shapes of the nanoparticles are changed from spherical to the lamina. The findings of heat transfer strength and surface friction coefficient are in excellent agreement with previously reported data.
Preparation and performance of natural rubber latex treatment for silica filled natural rubber composites
Authors: Wang Xingyu , Luo Zhu , Xu Yinhan , Zhong Jincheng , Zhang Hao , Liang Jiuming 
Published: April 2023

AbstractNatural rubber latex filled with silica can be used to prepare low‐cost green tires with low rolling resistance. However, low mixing efficiency and reduction of properties have become the major difficulty in the industry, because there are many polar groups on the surface of silica, and it is difficult to produce a strong interaction with a nonpolar rubber. In this paper, natural rubber latex masterbatch with silica was prepared, and easily mixed with natural rubber (NR) to obtain NR/silica composites. The silica after NRL treated in the rubber matrix characterized with well dispersion, good compatibility with rubber, and composites had weaker Payne effect and higher wet‐skid resistance. Meanwhile, the 100% and 300% tensile modulus increased by 8.5% and 14.47%, respectively, notably decreasing heat build‐up by 41.88%, compared to the composite prepared by dry mixing technology. Overall, both the dispersion and interfacial adhesion of silica in the rubber matrix have a significant synergistic effect on the properties of rubber composites. The strategy of preparing NR/silica composites provides new research avenues for the preparation of green tires and other rubber industries in the future.
Molecular Networking Accelerated Discovery of Biflavonoid Alkaloids from Cephalotaxus sinensis
Authors: Zhang Fuxin , Zhou Ruixi , Yang Tao , Yang Kailing , Xin Saisai , Zhang Jingwei , Li Yuqiu , Zhan Guanqun , Guo Zengjun 
Published: April 2023

AbstractFour undescribed biflavonoid alkaloids, sinenbiflavones A–D, were isolated from Cephalotaxus sinensis using a MS/MS‐based molecular networking guided strategy. Their structures were elucidated by series of spectroscopic methods (HR‐ESI‐MS, UV, IR, 1D, and 2D NMR). Sinenbiflavones A–D are the first examples of amentoflavone‐type (C‐3’–C‐8’’) biflavonoid alkaloids. Meanwhile, sinenbiflavones B and D are the unique C‐6‐methylated amentoflavone‐type biflavonoid alkaloids. Sinenbiflavone D showed weak SARS‐CoV‐2 3CLpro inhibitory activity with 43 % inhibition rate at 40 μM.
Synthesis of Muramyl‐δ‐Lactam in Spore Peptidoglycan of Clostridioides difficile
Authors: Kim Choon , Lee Mijoon , Birhanu Biruk T. , Hesek Dusan , Chang Mayland , Mobashery Shahriar 
Published: April 2023

AbstractClostridioides difficile is a spore‐forming human pathogen responsible for significant morbidity and mortality. Infections by this pathogen ensue dysbiosis of the intestinal tract, which leads to germination of the spores. The process of spore formation requires a transition for the cell‐wall peptidoglycan of the vegetative C. difficile to that of spores, which entails the formation of muramyl‐δ‐lactam. We describe a set of reactions for three recombinant C. difficile proteins, GerS, CwlD, and PdaA1, with the use of four synthetic peptidoglycan analogs. CwlD and PdaA1 excise the peptidoglycan stem peptide and the acetyl moiety of N‐acetyl muramate, respectively. The reaction of CwlD is accelerated in the presence of GerS. With the use of a suitable substrate, we document that PdaA1 catalyzes a novel zinc‐dependent transamidation/transpeptidation reaction, an unusual reaction that requires excision of the stem peptide as a pre‐requisite.
Deoxygenative Radical Boration of Inert Amides via a Combination of Relay and Cooperative Catalysis
Authors: Jiang Feng , Li Jing'an , Wang Xiaoming 
Published: April 2023

AbstractOne of the most challenging tasks in organic synthesis is to develop novel methodologies for rapid construction of complex molecules starting from easily available yet inert raw materials. In this context, multi‐catalysis strategies have attracted great attention in the discovery of new reactivity profiles that may allow access to many difficult or unattainable transformations. So far the deoxygenative functionalization of ubiquitous amides is usually achieved by nucleophilic attack on the imine or iminium ion intermediate formed via activation of the C=O bond, and these functionalization reagents were often confined to C‐based nucleophiles, which largely limited the diversity of the resultant amines. Herein, we disclose a combined strategy of relay and cooperative catalysis with a triple iridium‐photoredox‐organocatalysis system to achieve an unprecedented reductive boration of amides, affording valuable α‐amino boron products which are viable building blocks. In this transformation, the Ir‐catalyzed semi‐reduction of amides is successfully incorporated with photo‐organic catalyzed nucleophilic boryl radical addition, thus delivering the corresponding α‐boryl amines in high efficiency.
Experimental study on energy consumption characteristics of rotational–perforated static mixers
Authors: Meng Lichang , Gao Xuefang , Wang Dewu , Liu Yan , Wang Ruojin , Hu Baisong , Tang Meng , Zhang Shaofeng 
Published: April 2023

AbstractAn ideal static mixer can achieve efficient mixing at low pressure drops. Owing to the excellent performance of the tridimensional rotational flow sieve tray (TRST) in a gas–liquid two‐phase system, the TRST structure was modified into a rotational–perforated static mixer (RPSM) to enhance mixing in multicomponent liquid systems. The energy consumption characteristics of the RPSM were experimentally studied based on Reynolds numbers in the range of 986–7892, gap L = 0–80 mm, and relative angle γ = 0–45°. The effects of the element installation method, number, gap, relative angle, fluid Reynolds number, fluid properties, and other parameters on the RPSM pressure drop were also investigated. An interaction analysis of each factor was performed using the factorial design method and an empirical model of the RPSM Z‐factor was established. Additionally, pressure drop in the RPSM was compared with those of other commonly used static mixers. Results show that, when the element is backward‐installed, the pressure drop is higher than that in the forward direction because the fluid is constantly twisted. Moreover, the pressure drop increases with increasing element gap, and the average increase is 43.64% and 19.28% for the forward and backward installations, respectively. The influence of the relative angle on the pressure drop is mainly reflected when the gap L = 0. Subsequently, the degree of influence of each factor was determined, and the Z‐factor was calculated and found to be consistent with the experimental values (relative error of less than 15%).