bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use or abuse of antibiotics as prophylactic therapy in oral surgery: A systematic review
Authors: Cuevas-Gonzalez María Verónica , Cuevas-Gonzalez Juan Carlos , Espinosa-Cristóbal León Francisco , Donohue-Cornejo Alejandro , Reyes López Simón Yovanny , Saucedo Acuña Rosa Alicia , García Calderón Alma Graciela , Guzmán Gastelum Dalia Abril 
Published: September 2023

Backgroud:
Antibiotics are a type of medication routinely prescribed by dental professionals; however, it is very common that the administration is not justified. Around 15% of dentists admit that they have administered antibiotics unnecessarily more than once a week. The objective of this project is to identify the effectiveness of the use of antibiotics as prophylactic therapy in oral surgery, and to carry out an analysis of the alternatives to pharmacological therapy.

Methods:
The search strategy was carried out in the PubMed, Scopus, and ScienceDirect databases. For study selection, a first filter was carried out by title and abstract, which mentioned the use of prophylactic antibiotics in some type of oral surgery. To establish the risk of bias, the JBI Critical Appraisal Checklist for Randomized Controlled Trials was utilized.

Results:
The type of antibiotics most prescribed as prophylactic therapy were beta-lactams, which were indicated in 100% of the studies. Penicillins predominated, observing amoxicillin as the most indicated drug in 54.1% of the studies (n = 13) followed by the use of amoxicillin in conjunction with clavulanic acid in 33.3% of the studies (n = 8). Of the 21 studies included, 17 mention that there is insufficient evidence to support the use of antibiotics as prophylactic therapy in patients who will undergo some type of oral surgery.

Conclusions:
Without a doubt, the biggest challenge is to develop academic update strategies aimed at dentists with active clinical practice and dental students from educational and government institutions to provide updated information about the correct use of prescription drugs.
Pulmonary mucosa-associated lymphoid tissue lymphoma with Sjögren’s syndrome and literature review: A case report
Authors: Yang Limin , Qu Rongfeng , Liu Fang , Hu Chunmei 
Published: September 2023

Introduction:
A 54-year-old woman was admitted to hospital with chest tightness, shortness of breath, and chest pain on exertion. Her chest computed tomography showed a space-occupying lesion in the right lower lobe of the lung.

Case presentation:
The ultrasound-guided right lung mass biopsy showed mucosa-associated lymphoid tissue (MALT), and the patient was diagnosed with Sjögren’s syndrome (SS). The patient’s symptoms were partially relieved with chemotherapy.

Conclusions:
Autoimmune diseases like SS and systemic lupus erythematosus are recognized risk factors for pulmonary MALT. It is necessary to identify predictors of malignant transformation of SS to pulmonary MALT lymphoma.
Climate change adaptation needs a science of culture
Authors: Pisor Anne , Lansing J. Stephen , Magargal Kate 
Published: September 2023

There is global consensus that we must immediately prioritize climate change adaptation—change in response to or anticipation of risks from climate change. Some researchers and policymakers urge ‘transformative change’, a complete break from past practices, yet report having little data on whether new practices reduce the risks communities face, even over the short term. However, researchers have some leads: human communities have long generated solutions to changing climate, and scientists who study culture have examples of effective and persistent solutions. This theme issue discusses cultural adaptation to climate change, and in this paper, we review how processes of biological adaptation, including innovation, modification, selective retention and transmission, shape the landscapes decision-makers care about—from which solutions emerge in communities, to the spread of effective adaptations, to regional or global collective action. We introduce a comprehensive portal of data and models on cultural adaptation to climate change, and we outline ways forward.This article is part of the theme issue ‘Climate change adaptation needs a science of culture’.
Minority-group incubators and majority-group reservoirs support the diffusion of climate change adaptations
Authors: Turner Matthew A. , Singleton Alyson L. , Harris Mallory J. , Harryman Ian , Lopez Cesar Augusto , Arthur Ronan Forde , Muraida Caroline , Jones James Holland 
Published: September 2023

Successful climate change adaptation depends on the spread and maintenance of adaptive behaviours. Current theory suggests that the heterogeneity of metapopulation structure can help adaptations diffuse throughout a population. In this paper, we develop an agent-based model of the spread of adaptations in populations with minority–majority metapopulation structure, where subpopulations learn more or less frequently from their own group compared to the other group. In our simulations, minority–majority-structured populations with moderate degrees of in-group preference better spread and maintained an adaptation compared to populations with more equal-sized groups and weak homophily. Minority groups act as incubators for an adaptation, while majority groups act as reservoirs for an adaptation once it has spread widely. This means that adaptations diffuse throughout populations better when minority groups start out knowing an adaptation, as Indigenous populations often do, while cohesion among majority groups further promotes adaptation diffusion. Our work advances the goal of this theme issue by developing new theoretical insights and demonstrating the utility of cultural evolutionary theory and methods as important tools in the nascent science of culture that climate change adaptation needs.
This article is part of the theme issue ‘Climate change adaptation needs a science of culture’.
Navigating polycrisis: long-run socio-cultural factors shape response to changing climate
Authors: Hoyer Daniel , Bennett James S. , Reddish Jenny , Holder Samantha , Howard Robert , Benam Majid , Levine Jill , Ludlow Francis , Feinman Gary , Turchin Peter 
Published: September 2023

Climate variability and natural hazards like floods and earthquakes can act as environmental shocks or socioecological stressors leading to instability and suffering throughout human history. Yet, societies experience a wide range of outcomes when facing such challenges: some suffer from social unrest, civil violence or complete collapse; others prove more resilient and maintain key social functions. We currently lack a clear, generally agreed-upon conceptual framework and evidentiary base to explore what causes these divergent outcomes. Here, we discuss efforts to develop such a framework through the Crisis Database (CrisisDB) programme. We illustrate that the impact of environmental stressors is mediated through extant cultural, political and economic structures that evolve over extended timescales (decades to centuries). These structures can generate high resilience to major shocks, facilitate positive adaptation, or, alternatively, undermine collective action and lead to unrest, violence and even societal collapse. By exposing the ways that different societies have reacted to crises over their lifetime, this framework can help identify the factors and complex social–ecological interactions that either bolster or undermine resilience to contemporary climate shocks.
This article is part of the theme issue ‘Climate change adaptation needs a science of culture’.
Climate change and long-term human behaviour in the Neotropics: an archaeological view from the Global South
Authors: Scheinsohn Vivian , Muñoz A. Sebastián , Mondini Mariana 
Published: September 2023

In this paper, we argue for the inclusion of archaeology in discussions about how humans have contributed to and dealt with climate change, especially in the long term. We suggest Niche Construction Theory as a suitable framework to that end. In order to take into account both human and environmental variability, we also advocate for a situated perspective that includes the Global South as a source of knowledge production, and the Neotropics as a relevant case study to consider. To illustrate this, we review the mid-Holocene Hypsithermal period in the southern Puna and continental Patagonia, both in southern South America, by assessing the challenges posed by this climate period and the archaeological signatures of the time from a Niche Construction Theory perspective. Finally, we emphasize the importance of these considerations for policymaking.
This article is part of the theme issue ‘Climate change adaptation needs a science of culture’.
Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity
Authors: Rosberg Aylin , Merisaari Harri , Lewis John D. , Hashempour Niloofar , Lukkarinen Minna , Rasmussen Jerod M. , Scheinin Noora M. , Karlsson Linnea , Karlsson Hasse , Tuulari Jetro J. 
Published: September 2023

AbstractBackground/ObjectivesIt is well-established that parental obesity is a strong risk factor for associates with offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring brain in a manner that confers future obesity risk. Here, we investigated how pre-pregnancy maternal weight status influences the reward-related striatal areas of the offspring brain duringin uterodevelopment.MethodsWe used diffusion tensor imaging to quantify the microstructure of the striatal brain regions of interest in neonates (N = 116 mean gestational weeks at birth 39.88, SD = 1.14; and at scan 43.56, SD = 1.05). Linear regression was used to test the associations between maternal pre-pregnancy body mass index and infant striatal mean diffusivity.ResultsA strong positive association was found between the maternal pre-pregnancy body mass index and newborn left caudate nucleus mean diffusivity. Results remained unchanged after the adjustment for covariates.ConclusionsIn uteroexposure to maternal adiposity might have a growth impairing impact on the mean diffusivity of infant left caudate nucleus. Considering the involvement of caudate nucleus in regulating eating behaviour and food-related reward processing later in life, this finding calls for further investigations to define the prognostic relevance of early life caudate development and weight trajectories of the offspring.
Identification and Establishing Floral calendar in, Jimma zone of Oromia Ethiopia
Authors: Bareke Tura , Roba Kasim , Addi Admassu 
Published: September 2023

AbstractHoneybee colony performance as well as production of honey and other hive products depends on bee forages. The study was designed with objective to identify and establish flowering Calendar of bee plants for multiple honey production. Bee forage inventory was made in a plot size of 20mx20, for woody plants and 2mx2m for herbaceous bee forages. Based on the inventory of bee forages, pollen load collection and honey pollen analysis, 103 plant species were identified as source of nectar and pollen for honeybees. From identified plant species Ageratumconizoides, Guizotia scabra, Cordia africana, Datura arborea, Plantago lanceolatum, Rumex nervosus, andJusticia schimperina, were the major honey source plants in the area.The fresh weight of pollen collected at different months of the year indicated that significant amount of pollen was collected during September, October to November but decline of incoming pollen weight was recorded during, March and July. The major honey flow period of the area occurred during November and extends early December and late February. The minor honey flow also resulted May-June. The pollen analysis of honey samples revealed that three monofloral honey types were identified which include Guizotia,Vernonia and Croton monofloral honey types comprising the pollen frequency ranging from 45% to 100%. The study concluded that floral calendar of bee forages strictly dependent on the seasonal availability of food sources and beekeepers should get awareness on management of honeybee colonies with the flowering calendar in the area to increase frequency of honey production.
Heteroscedastic Personalized Regression Unveils Genetic Basis of Alzheimer’s Disease Stratified by Cognitive Level
Authors: Chen Zhirong , Wang Haohan 
Published: September 2023

AbstractIn contemporary medical research, patient heterogeneity plays a pivotal role in comprehending intricate diseases such as Alzheimer’s disease and various forms of cancer. Specifically, in the genomic analysis of Alzheimer’s disease, individual patients may exhibit unique causal mutations that significantly influence their therapeutic trajectory. Conventional models that share numerous parameters across all individuals struggle to discern this heterogeneity and identify the influential factors for individuals. To tackle this challenge, we propose an innovative approach called Heteroscedastic Personalized Regression (Het-PR) to estimate the heterogeneity across samples and obtain personalized models for each sample. We demonstrate the effectiveness and robustness of Het-PR through both simulation and real data experiments. In the simulation experiment, we show that Het-PR outperforms other state-of-the-art models in capturing inter-sample heterogeneity. In the real data experiment, we apply Het-PR to Alzheimer’s data and show that it can identify persuasive selected genetic factors for each individual patient. Interestingly, our results suggest that there might be different associative SNPs for AD patients stratified by different cognitive levels.Author summaryIn medical research, it has been observed that causes of a disease vary significantly among individuals, especially when looking at complex diseases like Alzheimer’s disease and cancer. For Alzheimer’s disease, obesity, age, gender, and depression may play different roles across different patients. When studying the genes of Alzheimer’s patients, we find that each person might have their own unique genetic changes that can affect their treatment. For example, Alzheimer’s patients with different genetic mutations may respond differently to the same treatment. Traditional research methods often miss these individual differences and can’t always pinpoint important personalized factors for each patient, because they usually use one model for all patients. To better understand these differences, we’ve introduced a new method, Heteroscedastic Personalized Regression (Het-PR), which generates a personalized model for each individual. Our experiments show that Het-PR is more effective than other leading methods in identifying these patient differences and recognizing Alzheimer’s genetic basis for each patient through both simulation and real data experiments. When we used Het-PR on real Alzheimer’s data, it helped us spot key genetic factors for each patient. Additionally, in our study, we excitedly find that different genetic markers in Alzheimer’s patients are possibly based on their cognitive abilities. Software for Heteroscedastic Personalized Regression is available inhttps://github.com/rong-hash/Het-PR.
PERFECT: Personalized Exercise Recommendation Framework and architECTure
Authors: Mehrabadi Milad Asgari , Khatibi Elahe , Jimah Tamara , Labbaf Sina , Borg Holly , Pimentel Pamela , Dutt Nikil , Guo Yuqing , Rahmani Amir M. 
Published: September 2023

AbstractBackgroundThere are indisputable health benefits to physical activity (PA). By collecting and displaying individual exercise behaviors via wearable trackers, the Internet of Things (IoT) and mobile health (mHealth) have made it possible to correlate users’ physiological data and daily activity information with their fitness requirements.ObjectiveThis study aimed to recommend personalized exercise to non-pregnant subjects to increase their physical activity level.MethodsWe developed smartphone and smartwatch applications to collect, monitor, and recommend exercises using a contextual multi-arm bandit framework. Twenty female college students were recruited to test this mHealth exercise program.ResultsOur findings indicated an increase in daily exercise duration (P< .001), with average satisfaction scores for the walking and recommendation system components of 4.31 (0.60) and 3.69 (0.95), respectively, on a scale of 1 to 5. In addition, participants’ confidence in their capacity to complete the suggested walking exercises safely and the study’s ability to satisfy their needs for physical activity both received average scores of over 4.ConclusionsA new era of mHealth systems has been ushered in by developments in the Internet of Things and wearable devices. Personalization of physical activity recommendations using such wearables has the potential to improve user engagement and performance. In this paper, we presented an exercise recommendation system based on reinforcement learning that uses biomarkers and the user’s context to recommend a unique walking exercise that enhances the user’s aerobic capacity.
Sequentially activated death complexes regulate pyroptosis and IL-1β release in response toYersiniablockade of immune signaling
Authors: Wertman Ronit Schwartz , Go Christina K. , Saller Benedikt S. , Groß Olaf , Scott Phillip , Brodsky Igor E. 
Published: September 2023

AbstractTheYersiniavirulence factor YopJ potently inhibits immune signaling in macrophages by blocking activation of the signaling kinases TAK1 and IKK. In response, macrophages trigger a backup pathway of host defense that mediates cell death via the apoptotic enzyme caspase-8 and pyroptotic enzyme caspase-1. While caspase-1 is normally activated within multiprotein inflammasome complexes that contain the adaptor ASC and NLRs, which act as sensors of pathogen virulence, caspase-1 activation followingYersiniablockade of TAK1/IKK surprisingly requires caspase-8 and is independent of all known inflammasome components. Here, we report that caspase-1 activation by caspase-8 requires both caspase-8 catalytic and auto-processing activity. Intriguingly, while caspase-8 serves as an essential initiator of caspase-1 activation, caspase-1 amplifies its own activation through a feed-forward loop involving auto-processing, caspase-1-dependent cleavage of the pore-forming protein GSDMD, and subsequent activation of the canonical NLRP3 inflammasome. Notably, while caspase-1 activation and cell death are independent of inflammasomes duringYersiniainfection, IL-1β release requires the canonical NLPR3 inflammasome. Critically, activation of caspase-8 and activation of the canonical inflammasome are kinetically and spatially separable events, as rapid capase-8 activation occurs within multiple foci throughout the cell, followed by delayed subsequent assembly of a single canonical inflammasome. Importantly, caspase-8 auto-processing normally serves to prevent RIPK3/MLKL-mediated necroptosis, and in caspase-8’s absence, MLKL triggers NLPR3 inflammasome activation and IL-1β release. Altogether, our findings reveal that functionally interconnected but temporally and spatially distinct death complexes differentially mediate pyroptosis and IL-1β release to ensure robust host defense against pathogen blockade of TAK1 and IKK.One Sentence SummaryYersinia-induced cell death and IL-1β release are driven by spatially and temporally distinct but functionally connected death complexes.
Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation
Authors: Hovhannisyan Yeranuhi , Li Zhenlin , Callon Domitille , Suspène Rodolphe , Batoumeni Vivien , Canette Alexis , Blanc Jocelyne , Hocini Hakim , Lefebvre Cécile , El-Jahrani Nora , L’honoré Aurore , Kordeli Ekaterini , Fornes Paul , Concordet Jean-Paul , Tachdjian Gérard , Rodriguez Anne-Marie , Vartanian Jean-Pierre , Béhin Anthony , Wahbi Karim , Joanne Pierre , Agbulut Onnik 
Published: September 2023

AbstractBeyond the observed alterations in cellular structure and mitochondria, the cellular mechanisms linking genetic mutations to the development of heart failure in patients affected by desmin defects remain unclear due, in part, to the lack of relevant human cardiomyocyte models. We investigated the role of mitochondria using cardiomyocytes derived from human induced pluripotent stem cells carrying the heterozygousDESE439Kdesmin mutation, that were either isolated from a patient or generated by gene editing. To increase physiological relevance, cells were either cultured on an anisotropic surface to obtain elongated and aligned cardiomyocytes, or as spheroids to create a micro- tissue. When applicable, results were confirmed with heart biopsies from the family harboringDESE439Kmutation. We show that mutant cardiomyocytes reproduce critical defects in mitochondrial architecture, respiratory capacity and metabolic activity as observed in patient’s heart tissue. To challenge the pathological mechanism, normal mitochondria were transferred inside the mutant cardiomyocytes. This treatment restored mitochondrial and contractile functions. This work demonstrates the crucial role of mitochondrial abnormalities in the pathophysiology of desmin-related cardiomyopathy, and opens-up new potential therapeutic perspectives.
Protein-Folding Chaperones Predict Structure-Function Relationships and Cancer Risk inBRCA1Mutation Carriers
Authors: Gracia Brant , Montes Patricia , Gutierrez Angelica Maria , Arun Banu , Karras Georgios Ioannis 
Published: September 2023

ABSTRACTIdentifying pathogenic mutations and predicting their impact on protein structure, function and phenotype remain major challenges in genome sciences. Protein-folding chaperones participate in structure-function relationships by facilitating the folding of protein variants encoded by mutant genes. Here, we utilize a high-throughput protein-protein interaction assay to test HSP70 and HSP90 chaperone interactions as predictors of pathogenicity for variants in the tumor suppressor BRCA1. Chaperones bind 77% of pathogenic BRCA1-BRCT variants, most of which engaged HSP70 more than HSP90. Remarkably, the magnitude of chaperone binding to variants is proportional to the degree of structural and phenotypic defect induced byBRCA1mutation. Quantitative chaperone interactions identified BRCA1-BRCT separation-of-function variants and hypomorphic alleles missed by pathogenicity prediction algorithms. Furthermore, increased chaperone binding signified greater cancer risk in humanBRCA1carriers. Altogether, our study showcases the utility of chaperones as quantitative cellular biosensors of variant folding and phenotypic severity.HIGHLIGHTSChaperones detect an abundance of pathogenic folding variants of BRCA1-BRCT.Degree of chaperone binding reflects severity of structural and phenotypic defect.Chaperones identify separation-of-function and hypomorphic variants.Chaperone interactions indicate penetrance and expressivity ofBRCA1alleles.