bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equilibrium electron beam parameters of the High Energy Photon Source
Authors: Xu Haisheng , Meng Cai , Peng Yuemei , Tian Saike , Wang Na , Cui Xiaohao , Du Chongchong , Duan Zhe , Guo Yuanyuan , He Ping , Huang Xiyang , Ji Daheng , Ji Hongfei , Jiao Yi , Li Jingyi , Li Nan , Li Xiaoyu , Lu Xiaohan , Liang Pengfei , Pan Weimin , Qu Huamin , Wang Bin , Wang Jiuqing , Wei Yuanyuan , Wan Jinyu , Xu Gang , Yan Fang , Yu Chenghui , Yue Sen , Zhang Xiang , Zhao Yaliang 
Published: January 2023

Abstract
Purpose
The physics design of the High Energy Photon Source (HEPS) was finished after many times of iteration. Hereby, the typical equilibrium electron beam parameters corresponding to the proposed two baseline operation modes in the baseline design of HEPS are presented.

Methods
To compute the equilibrium parameters of the electron beam, the lattice parameters, RF parameters, and the parameters of the insertion devices (IDs) were determined first. Furthermore, it is more precise to use the full-current electron beam parameters in the estimations of the performance of the synchrotron light. Therefore, not only the single-particle dynamics but also the current-dependent collective effects need to be considered in the computations of the full-current, equilibrium parameters of the electron beam. Both analytic computations and multi-particle tracking simulations were carried out.

Results
The full-current, equilibrium parameters of the electron beams in the HEPS storage ring are presented in this paper. Moreover, the main beam parameters in the injector (the booster and the LINAC), corresponding to the two baseline operation modes of the storage ring, are also presented.

Conclusion
The typical electron beam parameters corresponding to the two baseline operation modes are given in detail in this paper.
Phase-controlled van der Waals growth of wafer-scale 2D MoTe2 layers for integrated high-sensitivity broadband infrared photodetection
Authors: Wu Di , Guo Chenguang , Zeng Longhui , Ren Xiaoyan , Shi Zhifeng , Wen Long , Chen Qin , Zhang Meng , Li Xin Jian , Shan Chong-Xin , Jie Jiansheng 
Published: January 2023

AbstractBeing capable of sensing broadband infrared (IR) light is vitally important for wide-ranging applications from fundamental science to industrial purposes. Two-dimensional (2D) topological semimetals are being extensively explored for broadband IR detection due to their gapless electronic structure and the linear energy dispersion relation. However, the low charge separation efficiency, high noise level, and on-chip integration difficulty of these semimetals significantly hinder their further technological applications. Here, we demonstrate a facile thermal-assisted tellurization route for the van der Waals (vdW) growth of wafer-scale phase-controlled 2D MoTe2 layers. Importantly, the type-II Weyl semimetal 1T′-MoTe2 features a unique orthorhombic lattice structure with a broken inversion symmetry, which ensures efficient carrier transportation and thus reduces the carrier recombination. This characteristic is a key merit for the well-designed 1T′-MoTe2/Si vertical Schottky junction photodetector to achieve excellent performance with an ultrabroadband detection range of up to 10.6 µm and a large room temperature specific detectivity of over 108 Jones in the mid-infrared (MIR) range. Moreover, the large-area synthesis of 2D MoTe2 layers enables the demonstration of high-resolution uncooled MIR imaging capability by using an integrated device array. This work provides a new approach to assembling uncooled IR photodetectors based on 2D materials.
Phonon-assisted upconversion in twisted two-dimensional semiconductors
Authors: Dai Yuchen , Qi Pengfei , Tao Guangyi , Yao Guangjie , Shi Beibei , Liu Zhixin , Liu Zhengchang , He Xiao , Peng Pu , Dang Zhibo , Zheng Liheng , Zhang Tianhao , Gong Yongji , Guan Yan , Liu Kaihui , Fang Zheyu 
Published: January 2023

AbstractPhonon-assisted photon upconversion (UPC) is an anti-Stokes process in which incident photons achieve higher energy emission by absorbing phonons. This letter studies phonon-assisted UPC in twisted 2D semiconductors, in which an inverted contrast between UPC and conventional photoluminescence (PL) of WSe2 twisted bilayer is emergent. A 4-fold UPC enhancement is achieved in 5.5° twisted bilayer while PL weakens by half. Reduced interlayer exciton conversion efficiency driven by lattice relaxation, along with enhanced pump efficiency resulting from spectral redshift, lead to the rotation-angle-dependent UPC enhancement. The counterintuitive phenomenon provides a novel insight into a unique way that twisted angle affects UPC and light-matter interactions in 2D semiconductors. Furthermore, the UPC enhancement platform with various superimposable means offers an effective method for lighting bilayers and expanding the application prospect of 2D stacked van der Waals devices.
Tetra-color superresolution microscopy based on excitation spectral demixing
Authors: Wu Wanyan , Luo Shihang , Fan Chunyan , Yang Tianjie , Zhang Shuwen , Meng Wenxiang , Xu Tao , Ji Wei , Gu Lusheng 
Published: January 2023

AbstractMulticolor imaging allows protein colocalizations and organelle interactions to be studied in biological research, which is especially important for single-molecule localization microscopy (SMLM). Here, we propose a multicolor method called excitation-resolved stochastic optical reconstruction microscopy (ExR-STORM). The method, which is based on the excitation spectrum of fluorescent dyes, successfully separated four spectrally very close far-red organic fluorophores utilizing three excitation lasers with cross-talk of less than 3%. Dyes that are only 5 nm apart in the emission spectrum were resolved, resulting in negligible chromatic aberrations. This method was extended to three-dimensional (3D) imaging by combining the astigmatic method, providing a powerful tool for resolving 3D morphologies at the nanoscale.
AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer
Authors: Fu Yongming , Cao Tuoyu , Zou Xiaorui , Ye Yubing , Liu Youhong , Peng Yuchong , Deng Tanggang , Yin Linglong , Li Xiong 
Published: January 2023

AbstractOncogenic activation of PI3K/AKT signaling pathway, together with epigenetic aberrations are the characters of castration-resistant prostate cancer (CRPC). UHRF1 as a key epigenetic regulator, plays a critical role in prostate cancer (PCa) development, and its expression is positively correlated with the degree of malignancy. In this present study we investigated the potential regulatory mechanism of AKT1 on UHRF1, and further validated the in vitro and in vivo anticancer efficacy of AKT phosphorylation inhibitor MK2206 in combination with abiraterone. Both UHRF1 and p-AKT aberrantly overexpressed in the abiraterone-resistant PCa cells. Further studies revealed that AKT1 protein interacts with UHRF1, and AKT1 directly phosphorylates UHRF1 via the site Thr-210. MK2206 induced UHRF1 protein degradation by inhibiting AKT1-induced UHRF1 phosphorylation, and then reduced the interaction between UHRF1 and deubiquitinase USP7, while promoted the interaction between UHRF1 and E3 ubiquitin protein ligase BTRC. MK2206 significantly promoted the sensitivity of abiraterone-refractory PCa cells and xenografts to abiraterone by decreasing UHRF1 protein level, and reversed the phenotype of NEPC, evently induced cellular senescence and cell apoptosis. Altogether, our present study for the first time revealed a novel molecular mechanism of abiraterone resistance through PI3K/AKT-UHRF1 pathway, and provided a novel therapeutic modality by targeting PI3K/AKT1 to promote the drug sensitivity of abiraterone in PCa patients.
Transitional circulation and hemodynamic monitoring in newborn infants
Authors: Chakkarapani Aravanan Anbu , Roehr Charles C. , Hooper Stuart B. , te Pas Arjan B. , Gupta Samir ,   On behalf of the ESPR Neonatal Resuscitation section writing group
Published: January 2023

Abstract
Transitional circulation is normally transient after birth but can vary markedly between infants. It is actually in a state of transition between fetal (in utero) and neonatal (postnatal) circulation. In the absence of definitive clinical trials, information from applied physiological studies can be used to facilitate clinical decision making in the presence of hemodynamic compromise. This review summarizes the peculiar physiological features of the circulation as it transitions from one phenotype into another in term and preterm infants. The common causes of hemodynamic compromise during transition, intact umbilical cord resuscitation, and advanced hemodynamic monitoring are discussed.

Impact

Transitional circulation can vary markedly between infants.

There are alterations in preload, contractility, and afterload during the transition of circulation after birth in term and preterm infants.

Hemodynamic monitoring tools and technology during neonatal transition and utilization of bedside echocardiography during the neonatal transition are increasingly recognized.

Understanding the cardiovascular physiology of transition can help clinicians in making better decisions while managing infants with hemodynamic compromise.

The objective assessment of cardio-respiratory transition and understanding of physiology in normal and disease states have the potential of improving short- and long-term health outcomes.
The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains
Authors: Lacey Samuel E. , Foster Helen E. , Pigino Gaia 
Published: January 2023

AbstractAnterograde intraflagellar transport (IFT) trains are essential for cilia assembly and maintenance. These trains are formed of 22 IFT-A and IFT-B proteins that link structural and signaling cargos to microtubule motors for import into cilia. It remains unknown how the IFT-A/-B proteins are arranged into complexes and how these complexes polymerize into functional trains. Here we use in situ cryo-electron tomography ofChlamydomonas reinhardtiicilia and AlphaFold2 protein structure predictions to generate a molecular model of the entire anterograde train. We show how the conformations of both IFT-A and IFT-B are dependent on lateral interactions with neighboring repeats, suggesting that polymerization is required to cooperatively stabilize the complexes. Following three-dimensional classification, we reveal how IFT-B extends two flexible tethers to maintain a connection with IFT-A that can withstand the mechanical stresses present in actively beating cilia. Overall, our findings provide a framework for understanding the fundamental processes that govern cilia assembly.
Insecticidal activities of Streptomyces sp. KSF103 ethyl acetate extract against medically important mosquitoes and non-target organisms
Authors: Amelia-Yap Zheng Hua , Low Van Lun , Saeung Atiporn , Ng Fong Lee , Chen Chee Dhang , Hassandarvish Pouya , Tan Geok Yuan Annie , AbuBakar Sazaly , Azman Adzzie Shazleen 
Published: January 2023

AbstractA potentially novel actinobacterium isolated from forest soil, Streptomyces sp. KSF103 was evaluated for its insecticidal effect against several mosquito species namely Aedes aegypti, Aedes albopictus, Anopheles cracens and Culex quinquefasciatus. Mosquito larvae and adults were exposed to various concentrations of the ethyl acetate (EA) extract for 24 h. Considerable mortality was evident after the EA extract treatment for all four important vector mosquitoes. Larvicidal activity of the EA extract resulted in LC50 at 0.045 mg/mL and LC90 at 0.080 mg/mL for Ae. aegypti; LC50 at 0.060 mg/mL and LC90 at 0.247 mg/mL for Ae. albopictus; LC50 at 2.141 mg/mL and LC90 at 6.345 mg/mL for An. cracens; and LC50 at 0.272 mg/mL and LC90 at 0.980 mg/mL for Cx. quinquefasciatus. In adulticidal tests, the EA extract was the most toxic to Ae. albopictus adults (LD50 = 2.445 mg/mL; LD90 = 20.004 mg/mL), followed by An. cracens (LD50 = 5.121 mg/mL; LD90 = 147.854 mg/mL) and then Ae. aegypti (LD50 = 28.873 mg/mL; LD90 = 274.823 mg/mL). Additionally, the EA extract exhibited ovicidal activity against Ae. aegypti (LC50 = 0.715 mg/mL; LC90 = 6.956 mg/mL), Ae. albopictus (LC50 = 0.715 mg/mL; LC90 = 6.956 mg/mL), and An. cracens (LC50 = 0.715 mg/mL; LC90 = 6.956 mg/mL), evaluated up to 168 h post-treatment. It displayed no toxicity on the freshwater microalga Chlorella sp. Beijerinck UMACC 313, marine microalga Chlorella sp. Beijerinck UMACC 258 and the ant Odontoponera denticulata. In conclusion, the EA extract showed promising larvicidal, adulticidal and ovicidal activity against Ae. aegypti, Ae. albopictus, An. cracens, and Cx. quinquefasciatus (larvae only). The results suggest that the EA extract of Streptomyces sp. KSF103 has the potential to be used as an environmental-friendly approach in mosquito control. The current study would serve as an initial step toward complementing microbe-based bioinsecticides for synthetic insecticides against medically important mosquitoes.
Simulation of electrical conductivity for polymer silver nanowires systems
Authors: Mohammadpour-Haratbar Ali , Zare Yasser , Rhee Kyong Yop 
Published: January 2023

AbstractA simple model is developed for the conductivity of polymeric systems including silver nanowires (AgNWs). This model reveals the effects of interphase thickness, tunneling distance, waviness and aspect ratio of nanowires, as well as effective filler volume fraction on the percolation and electrical conductivity of AgNW-reinforced samples. The validity of this model is tested by using the measured data from several samples. Based on this model, the conductivity calculations are in proper accordance with the measured values. A large network and a low percolation onset are produced by nanowires with a high aspect ratio developing the nanocomposite conductivity. The results also show that a thicker interphase expands the network, thereby increasing the electrical conductivity. Furthermore, non-waved AgNWs exhibit more conductivity compared to wavy nanowires. It is concluded that the surface energies of polymer medium and nanowires have no effect on the conductivity of samples. On the other hand, the volume fraction and aspect ratio of nanowires, in addition to the interphase thickness and tunneling distance have the greatest influences on the conductivity of nanocomposites.
Diagnostic performance between in-house and commercial SARS-CoV-2 serological immunoassays including binding-specific antibody and surrogate virus neutralization test (sVNT)
Authors: Winichakoon Poramed , Wipasa Jiraprapa , Chawansuntati Kriangkrai , Salee Parichat , Sudjaritruk Tavitiya , Yasri Saowaluck , khamwan Chantana , Peerakam Rungnapa , Dankai Dararat , Chaiwarith Romanee 
Published: January 2023

AbstractThis study aimed to evaluate the correlation between in-house and commercial binding-specific IgG antibodies and between in-house and commercial SARS-CoV-2 surrogate virus neutralization tests (sVNT). Samples from healthcare workers who received vaccines against SARS-CoV-2 were tested for RBD-specific antibody, S-specific antibody, and in-house ELISA, commercial sVNT, and in-house sVNT, against wild-type SARS-CoV-2. Three hundred and five samples were included in the analysis. The correlation between S-specific binding antibodies and in-house ELISA was 0.96 (95% CI 0.96–0.97) and between RBD-specific antibodies and in-house ELISA was 0.96 (95% CI 0.95–0.97). The Cohen’s kappa between in-house sVNT and the commercial test was 0.90 (95% CI 0.80, 1.00). If using 90% inhibition of sVNT as the reference standard, the optimal cut-off value of RBD-specific antibodies was 442.7 BAU/mL, the kappa, sensitivity, and specificity being 0.99, 99%, and 100%, respectively. The optimal cut-off value of S-specific antibodies was 1155.9 BAU/mL, the kappa, sensitivity, and specificity being 0.99, 100%, and 99%, respectively. This study demonstrated a very strong correlation between in-house ELISA and 2 commercial assays. There was also a very strong correlation between in-house and commercial SARS-CoV-2 sVNT, a finding of particular interest which will inform future research.
Automated identification of blastocyst regions at different development stages
Authors: Farias Adolfo Flores-Saiffe , Chavez-Badiola Alejandro , Mendizabal-Ruiz Gerardo , Valencia-Murillo Roberto , Drakeley Andrew , Cohen Jacques , Cardenas-Esparza Elizabeth 
Published: January 2023

AbstractThe selection of the best single blastocyst for transfer is typically based on the assessment of the morphological characteristics of the zona pellucida (ZP), trophectoderm (TE), blastocoel (BC), and inner cell-mass (ICM), using subjective and observer-dependent grading protocols. We propose the first automatic method for segmenting all morphological structures during the different developmental stages of the blastocyst (i.e., expansion, hatching, and hatched). Our database contains 592 original raw images that were augmented to 2132 for training and 55 for validation. The mean Dice similarity coefficient (DSC) was 0.87 for all pixels, and for the BC, BG (background), ICM, TE, and ZP was 0.85, 0.96, 0.54, 0.63, and 0.71, respectively. Additionally, we tested our method against a public repository of 249 images resulting in accuracies of 0.96 and 0.93 and DSC of 0.67 and 0.67 for ICM and TE, respectively. A sensitivity analysis demonstrated that our method is robust, especially for the BC, BG, TE, and ZP. It is concluded that our approach can automatically segment blastocysts from different laboratory settings and developmental phases of the blastocysts, all within a single pipeline. This approach could increase the knowledge base for embryo selection.
Bacterial nanocellulose production using Cantaloupe juice, statistical optimization and characterization
Authors: El-Naggar Noura El-Ahmady , Mohammed A. B. Abeer , El-Malkey Sahar E. 
Published: January 2023

AbstractThe bacterial nanocellulose has been used in a wide range of biomedical applications including carriers for drug delivery, blood vessels, artificial skin and wound dressing. The total of ten morphologically different bacterial strains were screened for their potential to produce bacterial nanocellulose (BNC). Among these isolates,Bacillussp.strain SEE-3 exhibited potent ability to produce the bacterial nanocellulose. The crystallinity, particle size and morphology of the purified biosynthesized nanocellulose were characterized. The cellulose nanofibers possess a negatively charged surface of − 14.7 mV. The SEM images of the bacterial nanocellulose confirms the formation of fiber-shaped particles with diameters of 20.12‒47.36 nm. The TEM images show needle-shaped particles with diameters of 30‒40 nm and lengths of 560‒1400 nm. X-ray diffraction show that the obtained bacterial nanocellulose has crystallinity degree value of 79.58%. FTIR spectra revealed the characteristic bands of the cellulose crystalline structure. The thermogravimetric analysis revealed high thermal stability. Optimization of the bacterial nanocellulose production was achieved using Plackett–Burman and face centered central composite designs. Using the desirability function, the optimum conditions for maximum bacterial nanocellulose production was determined theoretically and verified experimentally. Maximum BNC production (20.31 g/L) byBacillussp.strain SEE-3 was obtained using medium volume; 100 mL/250 mL conical flask, inoculum size; 5%, v/v, citric acid; 1.5 g/L, yeast extract; 5 g/L, temperature; 37 °C, Na2HPO4; 3 g/L, an initial pH level of 5, Cantaloupe juice concentration of 81.27 percent and peptone 11.22 g/L.
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
Authors: Alula Kibrom M. , Delgado-Deida Yaritza , Callahan Rosemary , Till Andreas , Underwood Lucia , Thompson Winston E. , Souza Rhonda F. , Dassopoulos Themistocles , Onyiah Joseph , Venuprasad K. , Theiss Arianne L. 
Published: January 2023

AbstractAutophagy of damaged mitochondria, called mitophagy, is an important organelle quality control process involved in the pathogenesis of inflammation, cancer, aging, and age-associated diseases. Many of these disorders are associated with altered expression of the inner mitochondrial membrane (IMM) protein Prohibitin 1. The mechanisms whereby dysfunction occurring internally at the IMM and matrix activate events at the outer mitochondrial membrane (OMM) to induce mitophagy are not fully elucidated. Using the gastrointestinal epithelium as a model system highly susceptible to autophagy inhibition, we reveal a specific role of Prohibitin-induced mitophagy in maintaining intestinal homeostasis. We demonstrate that Prohibitin 1 induces mitophagy in response to increased mitochondrial reactive oxygen species (ROS) through binding to mitophagy receptor Nix/Bnip3L and independently of Parkin. Prohibitin 1 is required for ROS-induced Nix localization to mitochondria and maintaining homeostasis of epithelial cells highly susceptible to mitochondrial dysfunction.
Two phase feature-ranking for new soil dataset for Coxiella burnetii persistence and classification using machine learning models
Authors: Ahmad Fareed , Ghani Khan Muhammad Usman , Tahir Ahsen , Tipu Muhammad Yasin , Rabbani Masood , Shabbir Muhammad Zubair 
Published: January 2023

AbstractCoxiella burnetii (Cb) is a hardy, stealth bacterial pathogen lethal for humans and animals. Its tremendous resistance to the environment, ease of propagation, and incredibly low infectious dosage make it an attractive organism for biowarfare. Current research on the classification of Coxiella and features influencing its presence in the soil is generally confined to statistical techniques. Machine learning other than traditional approaches can help us better predict epidemiological modeling for this soil-based pathogen of public significance. We developed a two-phase feature-ranking technique for the pathogen on a new soil feature dataset. The feature ranking applies methods such as ReliefF (RLF), OneR (ONR), and correlation (CR) for the first phase and a combination of techniques utilizing weighted scores to determine the final soil attribute ranks in the second phase. Different classification methods such as Support Vector Machine (SVM), Linear Discriminant Analysis (LDA), Logistic Regression (LR), and Multi-Layer Perceptron (MLP) have been utilized for the classification of soil attribute dataset for Coxiella positive and negative soils. The feature-ranking methods established that potassium, chromium, cadmium, nitrogen, organic matter, and soluble salts are the most significant attributes. At the same time, manganese, clay, phosphorous, copper, and lead are the least contributing soil features for the prevalence of the bacteria. However, potassium is the most influential feature, and manganese is the least significant soil feature. The attribute ranking using RLF generates the most promising results among the ranking methods by generating an accuracy of 80.85% for MLP, 79.79% for LR, and 79.8% for LDA. Overall, SVM and MLP are the best-performing classifiers, where SVM yields an accuracy of 82.98% and 81.91% for attribute ranking by CR and RLF; and MLP generates an accuracy of 76.60% for ONR. Thus, machine models can help us better understand the environment, assisting in the prevalence of bacteria and decreasing the chances of false classification. Subsequently, this can assist in controlling epidemics and alleviating the devastating effect on the socio-economics of society.