bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lithofacies and Diagenetic Controls on Tight Silty and Sandy Upper Triassic Reservoirs of the Heshui Oil Field (Ordos Basin, North China)
Authors: Hu Chenlin , Han Changcheng , Tian Jijun , Fu Zhiqiang , Ma Jinghui , Algeo Thomas J. 
Published: January 2023

Summary
Tight oil, present in reservoirs of low porosity and permeability, can be regarded as a kind of unconventional resource. The tightening process in this kind of reservoir is controlled by the lithology and diagenetic history of the host formation. Upper Triassic Yanchang Formation siltstones and sandstones are the main reservoirs for hydrocarbon accumulation in the Heshui Oil Field (HOF), southwestern Ordos Basin. The reservoirs exhibit low porosity, low permeability, and strong heterogeneity. In recent years, numerous drillcores have been recovered from these units, but the porosity-permeability characteristics and burial history of these silty and sandy reservoirs have not yet been reported in detail. In this study, an integrated analysis of the lithofacies, diagenesis, and reservoir characteristics of the siltstones and sandstones was achieved using a combination of core and thin section, grain size, scanning electron microscopy (SEM), X-ray diffraction (XRD), δ13C and δ18O, mercury intrusion capillary pressure (MICP), and porosity and permeability data. Our primary goals were to quantify the porosity-permeability characteristics of these silty and sandy reservoirs, restore their diagenetic histories, and examine the paragenetic relationship of reservoir tightness to hydrocarbon accumulation. The silty and sandy reservoirs represent braided river delta facies consisting of compositionally and texturally immature sediments. In the burial environment, they underwent complex diagenetic processes that reduced porosity from an initial average of ~38% to the present ~8%. Porosity-destructive processes included compaction (~ –12.5%) and cementation (~ –21%), with increases in porosity related to grain dissolution (~ +2.2%) and tectonic fractures (~ +1.1%). The reservoirs underwent four diagenetic stages: (1) Penesyngenetic and Eogenetic A Stage (Late Triassic-Early Jurassic); (2) Eogenetic B Stage (Late Jurassic); (3) Early Mesogenetic A Stage (Early Cretaceous); and (4) Late Mesogenetic A Stage (Late Cretaceous to recent). Hydrocarbon charging of these reservoirs occurred in three pulses. Existing pore space was partly filled by hydrocarbons during the Eogenetic B Stage. A second hydrocarbon charging event occurred during the Early Mesogenetic A Stage, when residual primary intergranular pores and secondary dissolution pores were filled. A third hydrocarbon charging event occurred during the Late Mesogenetic A Stage, when the reservoirs were tight. Siltstone beds deposited in delta front environments are the main future exploration targets in the Chang 6 to 8 members. The results of this study provide a useful reference framework for future exploration of hydrocarbon resources in the Upper Triassic Yanchang Formation of the HOF, as well as potential insights into the evolution of similarly tight reservoirs in other basins.
Prediction of the incidence of colorectal cancer by routine laboratory tests and anthropometric measurements about metabolism
Authors: Cheng Binglu , Han Xu , Wan Hongjuan , Sun Zhijun , Wang Weisheng 
Published: January 2023

AbstractObjectiveTo investigate the relationship between metabolic disorders and the morbidity of colorectal cancer (CRC) compared with colorectal adenoma (CRA) and non-neoplastic inpatients, especially to investigate which anthropometric measures were better predictors of CRC.Methods80 patients with CRC, 80 patients with CRA and 80 non-neoplastic patients were selected from April 2017 to April 2019. The data of routine laboratory tests and anthropometric measurements about metabolism were analyzed retrospectively. Multinomial Logistic regression analysis was used to estimated odds ratio (OR) and 95% confidence interval (CI) for the risk of morbidity of CRC associated with potential risk factors.ResultsCompared with CRA, OR of CRC was enhanced by weight loss self-reported, lower-hemoglobin and hypoproteinemia. Compared with non-neoplastic controls, diabetes, higher waist-neck ratio (WNR) and The Metabolic syndrome (MetS) identifified by the Chinese Diabetes Society was associated with signifificant increasing risk of all CRC patients. while in male subgroup, OR of CRC was enhanced by diabetes, higher hip circumference, waist-neck ratio (WNR)>2.42 (OR = 2.795, 95%CI: 1.169-6.680), waist-height ratio (WHtR)>0.550 (OR = 3.009, 95%CI: 1.260-7.185) and MetS. In female subgroup, only waist-hip ratio (WHR)>0.890 (multivariable-adjusted OR = 3.354, 95%CI: 1.011-11.129) was significantly associated with increased risk of CRC compared with colorectal adenoma and non-neoplastic controls. The risk factors for CRA were similar to CRC compared with non-neoplastic controls.ConclusionAbdominal fat patients have a high incidence of CRC and CRA. For male, MetS, high level WNR and WHtR caused an increasing risk for CRC. For female, Only WHR is a high-risk factor. The patients with these high risk factors need to strengthen colorectal cancer screening, which is of great significance for the prevention and early detection of colorectal cancer.
SPRR1B+ keratinocytes prime oral mucosa for rapid wound healing
via STAT3 activation
Authors: Xuanyuan Xinyang , Zhang Li , Zheng Yang , Jiang Ruixin , Ma Yanni , Lei Ming , Xu Hui , Zeng Hanlin 
Published: January 2023

Abstract

Oral mucosa wounds repair faster with less scars than skin, which has been regarded as optimal wound healing system. However, the major cell subtypes that mediate mucosal fast healing remain unclear. By integrative analysis of bulk mRNA sequencing and single-cell sequencing data during wound healing in oral mucosa and skin, we identified one keratinocyte subpopulation, named SPRR1B+ keratinocytes, as major source of wound healing genes expression regulated by transcription factor STAT3. While SPRR1B+ keratinocytes were only enriched in healthy oral mucosa but not in skin, these keratinocytes were rapidly induced during skin wound healing, indicating that SPRR1B+ keratinocytes prime oral mucosa for fast wound healing. In short, by expression analysis of human oral and skin wound healing process at single-cell resolution followed by mice model validation, we identified STAT3-activated SPRR1B+ keratinocytes as the key cells priming mucosa fast repair, indicating its application in management of chronic or unhealing wounds.
Oral carbonhydrate 2 hours before surgery does’t increase the risk of reflux and aspiration：A randomized controlled trial in volunteers
Authors: Zhang Gang , Huang Xiaoyan , Feng Ji , Zhang Lan 
Published: January 2023

Abstract
Background: Due to concerns of both physicians and patients about aspiration, the duration of fasting before surgery is far beyond the recommended guideline, which will bring a series of adverse reactions. It still remains to be controversial that patients drink carbonhydrate before operation.
Methods: Volunteers were randomly divided into Group C and D. After 6 hours of fasting, the subjects in group C drank carbonhydrate less than 400ml, and the subjects in group D continued fasting without any beverage. The subjects in both groups received ultrasound evaluation every hour thereafter. The primary outcomes were the incidence of risk stomach, and the secondary outcomes were gastric volume and the visual analogue scale of hunger, thirst, and anxiety.
Results: There were no significant differences in general data. The total incidences of risk stomach in group C and D were 100% vs 13%, 70% vs 10%, 13.3% vs 6.6%, 10% vs 6.6% at T0,T1,T2,T3, respectively. There were no significant differences in the primary outcome between the two groups at T2 and T3. The gastric volume of group C and D were 36.08±16.90 vs 1.01±16.89, 25.67±20.67 vs 0.54±18.10, 6.89±18.32 vs -1.70±15.32, 2.74±16.48 vs -0.70±17.57 at T0, T1, T2, T3. The VAS of hunger and thirst and the VAS of anxiety in the two groups were 0.60±0.62 vs 1.00±0.70 and 0.70±0.70 vs 1.13±0.51, respectively.
Conclusion: Compared with non-beverage subjects, oral carbohydrate more than 2 hours before surgery not only did not increase the incidence of risk stomach, but also reduced preoperative hunger, thirst, and anxiety.
Trial registration: Registration date: 7/2/2021; Registration number: ChiCTR2100043166;
Evaluation of bioclinical markers to predict short term response to intravitreal anti-VEGF in treatment-naive diabetic macular edema and the “Fried Egg” sign : a novel OCT feature
Authors: Govindaraj Indu , Pradeep Neethu , Thulasiraman Mugundan , Mahalingam Maanasi , Rajendran Anand , Vasudevan Damodaran , Kariya Bharg N , Kothandaraman Aruna 
Published: January 2023

Abstract

Objective: To determine the incidence of suspended scattering particles in motion (SSPiM) and to assess baseline bioclinical markers in treatment-naive diabetic macular edema (DME) which can predict the short term response to intravitreal anti-VEGF.Design: Prospective observational study.Participants: Treatment-naive DME patients from January 2022 to June 2022 were included in the study.Methods: Treatment-naive DME cases were included and followed up for three months. Best corrected visual acuity (BCVA), SSPiM, HbA1c levels, hyperreflective dots (HRD), sub retinal fluid (SRF), central subfoveal thickness (CSFT), optical density ratio (ODR) of the largest cyst near the fovea, type of cyst (uniformly hyperreflective or fragmented intracystic hyperreflectivity called "fried egg" sign) at baseline were studied to predict response to treatment after anti-VEGF.Results:123 eyes of 88 patients were included in the study. Incidence of SSPiM was 64.5%.The mean incidence of poor responders was 35%. BCVA, ODR, hyperreflective cysts and presence of SSPiM were not associated with response to anti-VEGF. Higher CSFT, SRF, higher number of HRD, presence of SSPiM in the outer nuclear layer (ONL) and outer plexiform layer (OPL) were associated with short term good response to anti-VEGF. High HbA1c and presence of "fried egg" sign in the hyperreflective cysts were associated with poor response.Conclusion:Higher CSFT, SSPiM in the ONL and OPL, and higher HRD were associated with good response to antI-VEGF. High HbA1c and "fried egg" sign was associated with poor response to anti-VEGF. BCVA, presence of SSPiM and ODR were not associated with anti-VEGF response.
Trends in medical education: integrating medical humanities in all curricula——A new curriculum evaluation index system
Authors: Jin Weiqiong , Fang Yinghui , Lv Yijun 
Published: January 2023

Abstract
Background: Classrooms are the central front for education. In China's fight against COVID-19, doctors have saved lives with their exquisite medical skills and humane professional spirit and won widespread praise from the people. This is related to China's long-standing insistence on strengthening ideological and political education in the classroom and integrating medical humanistic elements into the medical curriculum. To consolidate the education’s effect, the Chinese government calls for integrating the content of ideological and political education into professional courses and puts forward the concept of ‘curriculum ideology and politics’, which coincides with the idea of strengthening medical humanistic education in medical courses. Therefore, curriculum ideology and politics have effectively integrated medical humanities into medical curriculum education. This study aimed to create an ‘Ideological and Political Teaching Evaluation Index System for Medical Courses’ to evaluate the effect of ideological and political education in medical courses.
Methods: This study organically combined ideological and political education, medical humanities, and medical professional curriculum education to construct an ‘Ideological and Political Teaching Evaluation System for Medical Courses’. This study used the Delphi method and recruited 13 Chinese medical education experts with senior professional titles to revise and assess the teaching evaluation index system and use the analytic hierarchy process to analyse the index system. The constructed ‘Ideological and Political Teaching Evaluation System for Medical Courses’ contained three first-level, nine second-level, and 27 third-level indicators.
Results: The index evaluation matrix satisfied the consistency test at all levels, with a consistency ratio of less than 0.1. Among them, the weight coefficients of the three first-level indicators such as value leading, knowledge teaching and quality training, are 36.782%, 30.460% and 32.759%, respectively. The weight distribution of each indicator is relatively balanced, and the second-level and third-level indicators’ setting is relatively reasonable.
Conclusions: This index system can guide medical courses’ ideological and political construction. At the end of the course, the teaching quality can be evaluated from the perspectives of teachers and students, which can effectively evaluate the ideological and political education and medical humanities improvement effect of this course and ensure the teaching quality.
Transdiagnostic associations between anger hostility and chemokine interferon-gamma inducible protein 10 (CXCL 10)
Authors: Soloey-Nilsen Hedda , Nygaard-Odeh Kristin , Kristiansen Magnhild Gangsoey , Kvig Erling Inge , Brekke Ole Lars , Mollnes Tom Eirik , Berk Michael , Reitan Solveig Klaebo , Oiesvold Terje 
Published: January 2023

Abstract
Background
Many psychiatric disorders are linked to low grade systemic inflammation as measured by systemic cytokine levels. Exploration of cytokines and immune activity and their role in psychiatric symptoms may inform pathobiology and treatment opportunities.
Methods
This was a cross sectional naturalistic study with 132 participants from a general open inpatient psychiatric ward at the Nordland Hospital Trust, Norway. Serum levels of 28 different cytokines were assessed. Psychiatric symptoms the last week were assessed by a self-rating scale (Symptom check list, SCL-90- R) and grouped in defined clusters. Multiple linear regression model was used for statistical analyses of associations between levels of cytokines and symptoms, adjusting for possible confounding factors.
Results
We found a positive association (p0.009) between the chemokine interferon-gamma inducible protein 10 (CXCL 10; IP-10) and the anger hostility cluster. No associations were found between the other symptom clusters and cytokines. IP-10 and the anger hostility cluster were positively associated (p 0.002) in the subgroup of patients using psychotropic medication, not in the subgroup not using psychotropic medication.
Conclusion
Our analyses revealed a significant positive association between the symptom cluster anger hostility in SCL-90-R and the chemokine IP-10 in the subgroup of patients using psychotropic medications.
Surface metallization of human hair via electroless copper-plating for self- supported nonenzymatic glucose sensor
Authors: Qian Kunpeng , Xu Yanfang , Miao Miao , Deng Dongmei , Luo Liqiang , Li Yuanyuan , Feng Xin 
Published: January 2023

Abstract
Surface engineering of human hair was successfully used as a self-supported electrochemical sensor to detect glucose in human serum. Polydopamine (PDA) was firstly grafted on hair by oxidative self-polymerization of dopamine and then the copper nanoparticles (CuNPs) were electrolessly deposited to achieve surface metallization of hair (hair@CuNPs). The hair@CuNPs composites with uniformly dispersed conductive layer in 8 µm thickness exhibited outstanding electrocatalytic activity towards glucose oxidation. Under optimal conditions, the amperometric response of glucose on hair@CuNPs composites as self-supported nonenzymatic glucose sensor covered two linear ranges of 0.002–5 mM and 5–35 mM, respectively, and the detection limit was 1.62 µM. The proposed method provides an easy and inexpensive way to fabricate hair@CuNPs biosensor for detecting glucose level in human serum samples, indicating that hair@CuNPs composites have promising practical applications in biological analysis.
Identification of novel compound ATP7B mutations in a child with rare Wilson disease: A case report
Authors: Ma Di , Zhang Jian-Ling , Huang Zhi-Hua , Ai Guo , Li Ge , Shu Sai-Nan 
Published: January 2023

Abstract
Background
Wilson disease (WD) is an autosomal-recessive metabolic disorder characterized by excess copper accumulation predominantly in the liver, brain, and cornea. Clinical diagnosis of WD remains a challenge because of its phenotypic heterogeneity. Here we describe the novel mutation (p. K838N) in the ATP7B gene of a child with WD. The mutation affects a conserved ATP-binding domain that is involved in the catalytic cycle. We also describe the clinical outcome of this patient.
Case presentation:
We reported a successful early diagnosis and treatment of WD in a 5-year-old boy who presented with unexplained liver dysfunction and hepatitis. Using whole-exome sequencing (WES), we identified a novel ATP7B mutation, K838N, which is valuable for early diagnosis of WD. After combination therapy with penicillamine, zinc supplement, low-copper diet, and supportive treatments for infections, liver problems, and jaundice, the patient’s medical condition gradually improved and stabilized in a clinical follow-up. We suggested that the novel K838N mutation in the case of WD might impair protein function and contribute to WD progression.
Conclusions
This case emphasizes the importance of WD diagnostic tests during clinical evaluation for patients presenting with an unexplained liver disorder in childhood for better outcomes and genetic counseling.
Urinary FBP1 as a novel biomarker for the diagnosis and progression of diabetic nephropathy
Authors: Zhang Mingchao , Wang Jing , Liu Yanyan , Lu Rui , Shi Jingsong , Chen Xi , Li Limin 
Published: January 2023

Abstract
Background: The pathogenesis of diabetic nephropathy (DN) is complex, and its onset is occult. It should be considered from multiple levels and angles using the concept of "system biology". New technologies, such as omics and high-throughput screening, provide more strategies for the screening of ideal markers of DN.
Methods: we used data-independent acquisition (DIA) mass spectrometry for urine proteomic analysis of DN patients at different pathological stages and healthy controls.
Results: Fructose-1,6-bisphosphatase 1 (FBP1) was specifically found in the urine of DN patients but not in that of healthy controls. Then, ELISA demonstrated that the urinary level of FBP1 in DN patients was significantly higher than that in healthy controls. We further verified the higher levels of urine FBP1 in association with DN than in association with type 2 diabetes mellitus (T2DM) and nondiabetic nephropathy. Receiver operating characteristic (ROC) curve analysis showed that FBP1 can distinguish DN and T2DM patients, and the AUC was 0.889 (sensitivity: 80%, specificity: 85%). Correlation analysis revealed that the level of urinary FBP1 was positively correlated with the progression of DN, as reflected by the fact that urinary FBP1 was negatively correlated with e-GFR and positively correlated with urea nitrogen, the interstitial inflammation score, and the interstitial fibrosis and tubular atrophy (IFTA) score.
Conclusions: The source of urinary FBP1 was traced, and it was revealed that it was specifically reduced in proximal renal tubules with the progression of DN, supporting the view that urinary FBP1 can be used as a marker for the progression of diabetic nephropathy. Together, our results indicate that FBP1 might not only be a novel marker for the diagnosis of DN but also be a new marker for the progression of DN.
Longitudinal deep neural networks for assessing metastatic brain cancer on a massive open benchmark.
Authors: Oermann Eric , Link Katherine , Schnurman Zane , Liu Chris , Kwon Young Joon (Fred) , Jiang Lavender Yao , Nasir-Moin Mustafa , Neifert Sean , Alzate Juan , Bernstein Kenneth , Qu Tanxia , Chen Viola , Yang Eunice , Golfinos John , Orringer Daniel , Kondziolka Douglas 
Published: January 2023

Abstract

The detection and tracking of metastatic cancer over the lifetime of a patient remains a major challenge in clinical trials and real-world care. 1–3 Recent advances in deep learning combined with massive, real-world datasets may enable the development of tools that can address this challenge. We present our work with the NYUMets Project to develop NYUMets-Brain and a novel longitudinal deep neural network (DNN), segmentation-through-time (STT). NYUMets-Brain is the world's largest, longitudinal, real-world dataset of cancer consisting of the imaging, clinical follow-up, and medical management of 1,429 patients with an average of six MRI studies obtained over 17 months per patient. The dataset includes over 2,367 expert segmentations of metastatic brain tumors, and 81,562 medical prescriptions. Using this dataset we developed Segmentation Through Time (STT), a deep neural network (DNN) which explicitly utilizes the longitudinal structure of the data and obtained state of the art results at tumor segmentation and detection of small (< 10 mm3) metastases. We also demonstrate that longitudinal measurements to assess the monthly rate of change of brain metastases over time are strongly predictive of overall survival (HR 1.27, 95%CI 1.18–1.38). We are releasing the entire dataset, codebase, trained model weights, and an interface for dataset access for other cancer researchers to build upon these results and to serve as a public benchmark. Massive real-world datasets and public benchmarks such as NYUMets-Brain may enable the tracking and detection of metastatic brain cancer, and be broadly applicable to advancing the development of AI models in other types of metastatic cancer as well.
Metaplastic breast carcinoma: sonographic and clinicopathologic comparison with infiltrating ductal carcinoma
Authors: Yao Mengxia , Wang Yin , Li Lian , Luo Siwei , Zhu Wu , Liu Yu , Liang Changhong 
Published: January 2023

Abstract
Background:There are limited data on the sonographic findings about metaplastic breast carcinoma (MBC) due to its rarity. This article aimed to determine the value of sonographic and clinicopathologic features in improving diagnostic accuracy of MBC and distinguishing it from infiltrating ductal carcinoma(IDC).
Methods: In the present study, 197 women (200 lesions) with IDC and 20 women (20 lesions) with MBC were retrospectively reviewed. Sonographic and clinicopathologic characteristics were compared between MBC and IDC.
Results: Relative to IDC, most of MBC were tumor grade III(95.0% vs 32.5%, P<0.001), with high Ki67(100.0% vs 75.0%, P<0.001) and triple negative subtype (90.0% vs 13.0%, P<0.001). On ultrasound findings, lesions of MBC tended to have big size (≥5cm,45.0% vs 1.5%, P<0.001), regular shape (45.0% vs 1.5%, P<0.001), circumscribed margin (40.0% vs 0.5%, P<0.001), complex cystic and solid echo(50.0% vs 3.5%, P<0.001) and posterior acoustic enhancement(95.0% vs 14.5%, P<0.001). The most important factors in distinguishing these two tumors were posterior acoustic enhancement, circumscribed margin and size by multilayer perceptron. In MBC cases, the estimated rate of local recurrence, distant metastasis and 5-year overall survival was 10.0%, 30.0% and 65.0%.
Conclusions: MBC is mainly manifested as a large breast mass with benign ultrasound findings in elderly women, which may be helpful for diagnosis of MBC and its differential diagnosis from other masses.