bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restoring carboxypeptidase E rescues BDNF maturation and neurogenesis in aged brains
Authors: Liu Hongmei , Jiang Dongfang , Yao Fuwen , Li Tingting , Zhou Bo , Zhao Song , Yang Keyan , Feng Haiping , Shen Jiaqi , Tang Jinglan , Wang Sijia , Zhang Yu-Xin , Wang Yun , Li Qian , Zhao Yongliang , Guo Caixia , Tang Tie-Shan 
Published: April 2023

Abstract
Adult neurogenesis declines with age due to the less functional neural stem cells (NSCs) and niches, but the underlying molecular bases for this impaired condition remain unclear. Here we analyzed &gt;55,000 single-cell transcriptomes from two discrete neurogenic niches across the mouse lifespan, and identified new features and populations in NSCs, new markers, and neurogenic regional-specific alternations during aging. Intercellular communication analysis revealed defects in brain-derived neurotrophic factor (BDNF)-TrkB signaling cascade in old NSCs. Carboxypeptidase E (CPE) was found to be highly enriched in NSCs, and played a crucial role in mature/proBDNF balance and adult neurogenesis. Diminishment of CPE with aging resulted in impaired generation of BDNF, thus limiting the neurogenesis in old neurogenic niches. Restoring CPE expression markedly rescued the adult neurogenesis by increasing the production of mature BDNF, offering an attractive therapeutic strategy for the treatment of certain disorders in regions associated with constitutive neurogenesis.
UV luminosity density results at z &gt; 8 from the first JWST/NIRCam fields: limitations of early data sets and the need for spectroscopy
Authors: Bouwens Rychard , Illingworth Garth , Oesch Pascal , Stefanon Mauro , Naidu Rohan , van Leeuwen Ivana , Magee Dan 
Published: April 2023

ABSTRACT
We have derived luminosity functions and set constraints on the UV luminosity and SFR density from z ∼ 17 to z ∼ 8, using the three most-studied JWST/NIRCam data sets, the SMACS0723, GLASS Parallel, and CEERS fields. We first used our own selections on two independent reductions of these data sets using the latest calibrations. A total of 18 z ∼ 8, 12 z ∼ 10, 5 z ∼ 13, and 1 z ∼ 17 candidate galaxies are identified over these fields in our primary reductions, with a similar number of candidates in our secondary reductions. We then use these two reductions, applying a quantitative discriminator, to segregate the full set of z ≥ 8 candidates reported over these fields from the literature, into three different samples, ‘robust’, ‘solid’, and ‘possible’. Using all of these samples, we then derive UV LF and luminosity density results at z ≥ 8, finding substantial differences. For example, including the full set of ‘solid’ and ‘possible’ z ≥ 12 candidates from the literature, we find UV luminosity densities, which are ∼7× and ∼20× higher than relying on the ‘robust’ candidates alone. These results indicate the evolution of the UV LF and luminosity densities at z ≥ 8 is still extremely uncertain, emphasizing the need for spectroscopy and deeper NIRCam + optical imaging to obtain reliable results. Nevertheless, even with the very conservative ‘robust’ approach to selections, both from our own and those of other studies, we find the luminosity density from luminous (MUV &lt; −19) galaxies to be ∼2 × larger than is easily achievable using constant star formation efficiency models, similar to what other early JWST results have suggested.
Intrinsic alignment as an RSD contaminant in the DESI survey
Authors: Lamman Claire , Eisenstein Daniel , Aguilar Jessica Nicole , Brooks David , de la Macorra Axel , Doel Peter , Font-Ribera Andreu , Gontcho A Gontcho Satya , Honscheid Klaus , Kehoe Robert , Kisner Theodore , Kremin Anthony , Landriau Martin , Levi Michael , Miquel Ramon , Moustakas John , Palanque-Delabrouille Nathalie , Poppett Claire , Schubnell Michael , Tarlé Gregory 
Published: April 2023

ABSTRACT
We measure the tidal alignment of the major axes of luminous red galaxies (LRGs) from the Legacy Imaging Survey and use it to infer the artificial redshift-space distortion signature that will arise from an orientation-dependent, surface-brightness selection in the Dark Energy Spectroscopic Instrument (DESI) survey. Using photometric redshifts to downweight the shape–density correlations due to weak lensing, we measure the intrinsic tidal alignment of LRGs. Separately, we estimate the net polarization of LRG orientations from DESI’s fibre-magnitude target selection to be of order 10−2 along the line of sight. Using these measurements and a linear tidal model, we forecast a 0.5 per cent fractional decrease on the quadrupole of the two-point correlation function for projected separations of 40–80 h−1 Mpc. We also use a halo catalogue from the Abacussummit cosmological simulation suite to reproduce this false quadrupole.
The role of China in the international financial system
Authors: Gao Haihong 
Published: April 2023

AbstractChina’s interaction with the international financial system is driven by its growing economic importance in the world. However, China’s financial influence has been much under-presented compared with its economic power. This mismatch provides an opportunity for China to promote greater inclusiveness and better balance of power in global financial governance. The accelerated financial opening-up, exchange-rate flexibility, and deepened domestic reform also nourished the ambition of internationalization of the renminbi that would have impact on the global reserve currency system. This paper investigates the motivations behind China’s engagements with the international financial system, the approaches China adopted to achieve its goals, and the key domestic policies required for China to gain more weight in the global financial market.
European monetary regimes after the fall of Bretton Woods: a political economy approach
Authors: Farese Giovanni , Guerrieri Paolo , Padoan Pier Carlo 
Published: April 2023

AbstractAfter the fall of the Bretton Woods system, the EU initiated an original path towards monetary integration which led to the establishment of the European monetary system (EMS) in the 1980s and the economic monetary union (EMU) in the 1990s. This path was an alternative to the floating exchange rate regime which many other countries decided to follow. Adopting a political economy approach, in this paper we reconstruct the main phases of this process, from the 1970s up until today, arguing that they cannot be explained only in terms of costs and benefits of alternative exchange rate configuration, but should consider political as well as economic factors—both domestic and international ones—and the interaction between European monetary and real integration. Ultimately, the predominance of political factors led to an underestimation of the economic difficulties generated by the coexistence of irrevocable exchange rates and full capital mobility. We suggest that new policy instruments and institutional changes are needed to make the common currency workable in the long run. The mandatory path should be towards a more deeply integrated Europe. Such integration is essential to enable the European monetary union to confront with future challenges.
Exorbitant privilege and fiscal autonomy
Authors: Subacchi Paola , van den Noord Paul 
Published: April 2023

AbstractAn aspect of the ‘exorbitant privilege’ we examine in this paper is the ability of the reserve currency issuer to run expansionary fiscal policies to stabilize the economy when a negative shock occurs without triggering an adverse reaction of foreign lenders, including, in particular, higher interest rates imposed by global capital markets. To explore this ‘privilege’ we look at the G7, a group of advanced economies that enjoy larger fiscal space than other countries. We estimate a panel regression model to explain the differences in magnitude of fiscal policy responses to common shocks as a function of countries’ reserve currency status. We find that, indeed, the prevalence of this channel is not rejected by the data and that in fact it seems to have become stronger over time, supported by the global build-up of currency reserves.
Control of contextual memory through interneuronal α5-GABAA receptors
Authors: Zhu Mengwen , Abdulzahir Alifayaz , Perkins Mark G , Chu Chan C , Krause Bryan M , Casey Cameron , Lennertz Richard , Ruhl David , Hentschke Harald , Nagarajan Rajasekar , Chapman Edwin R , Rudolph Uwe , Fanselow Michael S , Pearce Robert A 
Published: April 2023

Abstract
γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABAARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal neuron dendrites have long been considered responsible, but here we report that mice in which α5-GABAARs have been eliminated from pyramidal neurons (α5-pyr-KO) continue to form strong spatial engrams and that they remain as sensitive as their pseudo-wild-type (p-WT) littermates to etomidate-induced suppression of place cells and spatial engrams. By contrast, mice with selective knockout in interneurons (α5-i-KO) no longer exhibit etomidate-induced suppression of place cells. In addition, the strength of spatial engrams is lower in α5-i-KO mice than p-WT littermates under control conditions. Consistent with the established role of the hippocampus in contextual fear conditioning, α5-i-KO mice resisted etomidate’s suppression of freezing to context, but so too did α5-pyr-KO mice, supporting a role for extra-hippocampal regions in the development of contextual fear memory. Overall, our results indicate that interneuronal α5-GABAARs serve a physiological role in promoting spatial learning and that they mediate suppression of hippocampus-dependent contextual memory by etomidate.
Mosquito bite prevention through self-assembled cellulose nanocrystals
Authors: Voignac Daniel , Sar-Shalom Evyatar , Paltiel Yossi , Shoseyov Oded , Bohbot Jonathan 
Published: April 2023

Abstract
Mosquitoes are the deadliest of all combined insects and animals affecting millions and killing hundreds or thousands of people each year. Existing protection methods however are limited and include volatile compounds that actively repel mosquitoes such as N,N-Diethyl-meta-toluamide (DEET) or different essential oils such as geraniol and citronella. Most are odorous compounds and require organic solvents for dispersion. This work investigates the barrier properties of cellulose nanocrystals (CNCs). CNCs are known to self-assemble in strong, transparent, chemical barrier films. They are fully bio-based, and their surface chemistry is ideal for aqueous dispersion of many compounds. This work saw a significant 80% decrease in feeding on human skin when a thin CNC coat was applied. The effect was further confirmed by artificial feeding on Aedes aegypti wherein CNC appears to act as a chemical camouflage to the many cues sought by the insects. The combined effect of CNC with indole reduced egg laying post exposure to mammalian blood close to null with 99.4% less eggs as compared to control. The chemical barrier effect was assessed through a simple headspace experiment showing that the same CNC coat blocked the passage of ammonium hydroxide vapor, a commonly used mosquito attractant, when applied on a filter paper membrane.
Association of Remnant-like Particle Cholesterol with Major Adverse Cardiovascular Events in Subjects with Different Levels of Proprotein Convertase Subtilisin/Kexin 9: A 9.5-year Follow-up Study in a Beijing Community Population
Authors: Wang Xiaona , Tie Ruping , Cao Ruihua , Yang Xu , Xiao Wenkai , Sheng Li , Ye Ping 
Published: April 2023

Objective:
The purpose of this study was to determine the relationship between remnant-like particle cholesterol (RLP-C) and major adverse cardiovascular events (MACEs) in patients with different levels of proprotein convertase subtilisin/kexin 9 (PCSK9).

Methods:
From September 2007 to January 2009, 1,859 subjects in Pingguoyuan communities in Beijing were initially screened. After excluding those with bedridden status, mental illness, severe systemic diseases, and missing data, 1,680 subjects were recruited for follow up. All recruited subjects were followed up from February 2013 to September 2013 (181 subjects were lost to follow-up) and from June 2017 to September 2018 (174 subjects were lost to follow up). Finally, 1,325 subjects were included in the study. General demographic characteristics, lifestyle and behaviors, disease history and use of medication was collected. Levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fast blood glucose, RLP-C, low-density lipoprotein triglycerides and PCSK9 were measured. The levels of RLP-C (low: RLP-C ≤ 157 mg/L; high: RLP-C > 157 mg/L) and PCSK9 (low: PCSK9 ≤ 135.87 μg/L; high: PCSK9 > 135.87 μg/L) were represented using quartiles. Subjects were categorized into 4 groups according to their RLP-C and PCSK9 levels: Q4, high levels of RLP-C with high levels of PCSK9; Q3, high levels of RLP-C with low levels of PCSK9; Q2, low levels of RLP-C with high levels of PCSK9; and Q1, low levels of RLP-C with low levels of PCSK9. The association of RLP-C with MACEs in subjects with different PCSK9 levels was evaluated.

Results:
After a median follow-up of 9.5 years, 1,325 subjects were included in the study and a total of 191 MACEs had occurred. The incidence of MACEs was higher in the RLP-C > 157 mg/L group than the RLP-C ≤ 157 mg/L group (18.40% vs. 10.42%). Cox proportional hazards regression model analysis showed that increased RLP-C levels were associated with an increased risk of MACEs (hazard ratio: 1.405; 95% confidence interval: 1.005–1.964; P < 0.005). The incidence of MACEs was higher in the high RLP-C/PCSK9 group vs. the low RLP-C/PCSK9 group (20.68% vs. 8.76%). Cox proportional hazards regression model analysis showed that RLP-C was associated with an increased risk of MACEs in subjects with high PCSK9 levels independent of traditional risk factors (hazard ratio: 1.791; 95% confidence interval: 1.168–2.825; P = 0.001), but not in those with low PCSK9 levels.

Conclusions:
RLP-C was identified as a risk factor for MACEs, particularly in subjects with high PCSK9 levels. Lowering PCSK9 levels may reduce residual risk in subjects with elevated plasma RLP-C levels.
The impact of epidural analgesia for acute pancreatitis on maternal and fetal outcome: a cohort study
Authors: Khan Salman , Rizwan Umer Muhammad , Ali Zubair , Khan Muhammad A. , Raza Amna , Nadeem Amjad , Hassan Muddasir Reyaz , Mumtaz Hassan 
Published: April 2023

Introduction:
It is anticipated that between 1 in 10, 000 and 1 in 30, 000 pregnancies will be affected by acute pancreatitis (AP). The authors wanted to evaluate the impact of epidural analgesia on maternal and fetal outcomes and its effectiveness in the pain treatment of obstetric patients with AP.

Methodology:
The period for this cohort research was from January 2022 to September 2022. Fifty pregnant women with AP symptoms were enrolled in the study. Conservative medical management was done using intravenous (i.v.) analgesics, including fentanyl and tramadol. Fentanyl was infused i.v. at a rate of 1 µg/kg every hour, while tramadol was bolused i.v. at 100 mg/kg every 8 h. Boluses of 10–15 ml of 0.1% ropivacaine were injected into the L1–L2 interspace at 2–3-h intervals to provide high lumbar epidural analgesia.

Results:
In this study, 10 patients were given an i.v. infusion of fentanyl, and 20 patients were given tramadol boluses. Epidural analgesia showed the most promising results decreasing the visual analog scale score from 9 to 2 in half of the patients. Most fetal complications were noticed in the tramadol group, including prematurity, respiratory distress, and babies requiring noninvasive ventilation.

Conclusion:
Patients with AP during pregnancy may benefit from a new technique for simultaneous analgesia during labor and cesarean section administered via a single catheter. When AP is detected and treated during pregnancy, the mother and child benefit from pain control and recovery.
Hypokalemia as a responsible factor related with the severity of hepatic encephalopathy: a wide multination cross-sectional study
Authors: Ullah Himayat , Shabana Hossam , Rady Mohamed Akl , Abdelsameea Eman , Youssef Mohamed I. , Helmy Housam Ahmed , Mustafa Ghulam , Elghafar Tamer Samir Abd , Almarshad Feras , Alshahrani Abdulrahman , Abdel-Samiee Mohamed , Alwadai Abdulmajeed Ahmed , Zedan Hendawy Abdel-moety , khalil Farag , Ahmed Mahmoud Osama , Kassem Arafat , Omar Marwa M. , Kamel Shimaa Y. , El Deen Mohamed El sheref Saad , Hassan Mohamed Hassan Attia , AboShabaan Hind S. , Elgendy Wagih , Zaghloul Amr M. , Mohamed Ibrahim Ghoniem Ramadan , Zayed Esam , Abdelghaffar Amir , Aboufarrag Galal Abdelhameed , Seif A.S. , Elmahdy Hussein Ahmed , Said Ashraf , Farahat Ali , El-Sayed Lashin Hesham , Elmahdi Essam , Abuamer Ahmed 
Published: April 2023

Background:
Several precipitating factors of hepatic encephalopathy have been recognized and studied. Hepatic encephalopathy which is a frequent and grave complication of liver failure, is associated with multiple biochemical changes like high serum ammonia, mercaptan and phenol levels, low albumin levels and derangements in electrolytes. It is characterized by a range of neuronal and psychological aberrations mainly due to the inability of liver to metabolize different neurotoxic chemicals produced in the body. Hypokalemia is one of the most important findings in hepatic encephalopathy and postulated as a precipitating factor of the condition. The authors aimed to know the frequency of hypokalemia and its relation to the severity of hepatic encephalopathy.

Methods:
After taking approval from the hospital ethical review committee, a total of 5000 patients with hepatic encephalopathy were recruited by consecutive sampling. They were interviewed, examined and investigated for serum potassium levels and other precipitating factors of hepatic encephalopathy.

Results:
Total of 5000 patients including 3070 (61.4%) males and 1930 (38.6%) females, aging 13 years and above were studied. The frequency of hypokalemia was 78% (3900 patients). Relating the serum potassium level with the severity of hepatic encephalopathy, 1200 (60%) out of 2000 patients with serum potassium below 2.5 mEq/l were in grade 4 (40%) and 800 out of 2000 were in grade 3 encephalopathy. On the other hand, only 700 patients (6.4%) out 1100 with serum potassium above 3.4 mEq/l were in grade 4 encephalopathy.

Conclusion:
Hypokalemia is a frequent finding in patients with hepatic encephalopathy and found to be directly related to its severity.
Sigmoid mesocolon internal hernia: a case report
Authors: Lukman Kiki , Sulthana Bambang Am Am Setya , Andreas Rio , Nugraha Prapanca 
Published: April 2023

Introduction and importance:
Primary internal hernias are rare in adults. Internal hernias present clinically as a sign of small intestinal obstruction. If left untreated, internal hernias might lead to high morbidity and mortality due to strangulation. Internal hernias are usually diagnosed intraoperatively. Here, we present an internal hernia diagnosed with an abdominal computed tomography (CT) scan. The importance of preoperative diagnosis for internal hernias leads to early surgery and keeps the patient from suffering intestinal strangulation.

Case presentation:
We report here the case of a 67-year-old male who presented with acute intestinal obstruction and underwent an abdominal CT scan. The patient was diagnosed with an internal hernia from the imaging of the abdominal CT scan and scheduled for an exploratory laparotomy. An internal hernia was found in the mesocolon of the sigmoid colon; one loop of jejunum was trapped in the hernia defect. After reduction, the hernial defect was closed; no resections were done, and the patient was discharged after 5 days without complication.

Clinical discussion:
Our finding represents a transmesosigmoid hernia, a rare variant of sigmoid mesocolon hernias. The clinical sign and the judgment of the surgeon for the diagnosis of an internal hernia became important factors related to the patient’s outcome.

Conclusion:
The proper adjunct imaging, correct diagnosis, and timing of surgery for internal hernias save the patient from morbidity or intestinal death.
Vertebromedullary hydatidosis: a case report
Authors: Haouas Mohammed Y. , Jihri Abdelhamid , Makhchoune Marouane , Limi Jihane , Lakhdar Abdelhakim 
Published: April 2023

Introduction and importance:
The contamination of humans with the larval form of the tapeworm Echinococcus granulosus results in the parasitic disease known as hypatidosis. Even though hydatid disease is widespread in Maghreb nations, bone hydatidosis is still uncommon.

Case presentation:
This article presents the case of a 12-year-old child with no particular pathological antecedent, who presents a spinal cord compression syndrome evolving gradually for 2 weeks whose objective clinical examination found a 2/5 paraparesis with a sharp pyramidal syndrome and subxiphoid sensory level. Medullary MRI has objectified an aspect of hydatid cysts at the level of D8 D9 and D10 compressing the spinal cord.

Clinical discussion:
Management was surgical by decompression by laminectomy of stage D8, D9, and D10 under general anesthesia and put on albendazole, the diagnosis was confirmed by histopathological examination, the evolution was marked by a partial recovery of deficit.

Conclusions:
Clinical symptomatology is vague with a gradually inescapable movement towards spinal or root pressure.
Wernicke encephalopathy revealed by areflexic flaccid tetraparesis associated with gravidarum hyperemesis
Authors: Ben Chaib Rajae , Mekkaoui Ikram , Chetouani Zaima , kaba Ousmane , Markaoui Ikam , Elmezzeoui Sanae , Bkiyar Houssam , Housni Brahim 
Published: April 2023

Introduction:
Wernicke’s encephalopathy is an acute neuropsychiatric syndrome resulting from thiamine deficiency, which is associated with significant morbidity and mortality. The diagnosis of Wernicke’s encephalopathy is based on the clinical manifestations and rapid reversal of symptoms with thiamine.

Case presentation:
The authors present the case of a 25-year-old female patient at the 19th week of gestation (Gravid 1 para 0) with an unremarkable medical history who was admitted to the hospital for an areflexic flaccid tetraparesis with ataxia after persistent vomiting. The brain and spinal MRIs did not reveal any abnormalities, and the evolution was marked by an important improvement after supplementation with thiamine.

Conclusion:
Gayet Wernicke encephalopathy is a medical emergency. Clinical symptoms are inconstant and varied. MRI is the reference examination to confirm the diagnosis, but in 40% of cases it is strictly normal. Early thiamine administration can prevent morbidity and mortality in pregnant women.