bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of sodium bicarbonate ingestion on swimming interval performance in trained competitive swimmers
Authors: Gough L. A. , Newbury J. W. , Price M. 
Published: April 2023

AbstractThe use of sodium bicarbonate (NaHCO3) supplementation to improve repeated high-intensity performance is recommended; however, most swimming performance studies examine time trial efforts rather than repeated swims with interspersed recovery that are more indicative of training sessions. The aim of this study, therefore, was to investigate the effects of 0.3 g.kg−1 BM NaHCO3 supplementation on sprint interval swimming (8 × 50 m) in regionally trained swimmers. Fourteen regionally competitive male swimmers (body mass (BM): 73 ± 8 kg) volunteered for this double-blind, randomised, crossover designed study. Each participant was asked to swim 8 × 50 m (front crawl) at a maximum intensity from a diving block, interspersed with 50 m active recovery swimming. After one familiarisation trial, this was repeated on two separate occasions whereby participants ingested either 0.3 g.kg−1 BM NaHCO3 or 0.05 g.kg−1 BM sodium chloride (placebo) in solution 60 min prior to exercise. Whilst there were no differences in time to complete between sprints 1–4 (p > 0.05), improvements were observed in sprint 5 (p = 0.011; ES = 0.26), 6 (p = 0.014; ES = 0.39), 7 (p = 0.005; ES = 0.60), and 8 (p = 0.004; ES = 0.79). Following NaHCO3 supplementation, pH was greater at 60 min (p < 0.001; ES = 3.09), whilst HCO3− was greater at 60 min (p < 0.001; ES = 3.23) and post-exercise (p = 0.016; ES = 0.53) compared to placebo. These findings suggest NaHCO3 supplementation can improve the latter stages of sprint interval swimming performance, which is likely due to the augmentation of pH and HCO3− prior to exercise and the subsequent increase in buffering capacity during exercise.
Association between the AKT1 single nucleotide polymorphism (rs2498786, rs2494752 and rs5811155) and microscopic polyangiitis risk in a Chinese population
Authors: Li Lizhen , Rao Jinlan , Lan Jingjing , Zhu Yan , Gong Aimei , Chu Liepeng , Feng Fei , Xue Chao 
Published: April 2023

AbstractMicroscopic polyangiitis (MPA) is an autoimmune disease, characterized by ANCA in blood and necrotizing inflammation of small and medium-sized vessels, one of the three clinical phenotypes of ANCA-associated vasculitis (AAV). Autophagy has been confirmed to be involved in the pathogenesis of AAV. AKT1 is one of the autophagy-regulated proteins. Its single nucleotide polymorphisms (SNPs) are associated with multiple immune-related diseases, but there are rarely studies in AAV. The incidence rate of AAV has a notable geographic difference, and MPA is predominant in China. The aim of this study was to investigate the association between AKT1 SNP and MPA risk. Genotypes of 8 loci in AKT1 were evaluated by multiplex polymerase chain reaction (PCR) and high-throughput sequencing in 416 people, including 208 MPA patients and 208 healthy volunteers from Guangxi in China. Additionally, data of 387 healthy volunteers from China were obtained from the 1000Genomes Project on public database. Differences were observed between the loci (rs2498786, rs2494752, and rs5811155) genotypes in AKT1 and MPA risk (P = 7.0 × 10–4, P = 3.0 × 10–4, and P = 5.9 × 10–5, respectively). A negative association was detected in the Dominant model (P = 1.2 × 10–3, P = 2.0 × 10–4 and P = 3.6 × 10–5, respectively). A haplotype (G-G-T) was associated with MPA risk negatively (P = 7.0 × 10–4). This study suggests that alleles (rs2498786 G, rs2494752 G and rs5811155 insT) are protective factors for MPA and alleles (rs2494752 G and rs5811155 insT) for MPO-ANCA in patients with MPA. There is a haplotype (G-G-T), which is a protective factor for MPA. It suggests that the role of AKT1 in MPA/AAV needs further study to provide more intervention targets for MPA/AAV.
Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan
Authors: Sakakida Tomoki , Ishikawa Takeshi , Doi Toshifumi , Morita Ryuichi , Kataoka Seita , Miyake Hayato , Yamaguchi Kanji , Moriguchi Michihisa , Sogame Yoshio , Yasuda Hiroaki , Iwasaku Masahiro , Konishi Hideyuki , Takayama Koichi , Itoh Yoshito 
Published: April 2023

AbstractBackgroundSpecial subtypes of pancreatic cancer, such as acinar cell carcinoma (ACC), adenosquamous carcinoma (ASC), and anaplastic carcinoma of the pancreas (ACP), are rare, and so data on them are limited. Using the C-CAT database, we analyzed clinical and genomic characteristics of patients with these and evaluated differences on comparison with pancreatic ductal adenocarcinoma (PDAC) patients.MethodsWe retrospectively reviewed data on 2691 patients with unresectable pancreatic cancer: ACC, ASC, ACP, and PDAC, entered into C-CAT from June 2019 to December 2021. The clinical features, MSI/TMB status, genomic alterations, overall response rate (ORR), disease control rate (DCR), and time to treatment failure (TTF) on receiving FOLFIRINOX (FFX) or GEM + nab-PTX (GnP) therapy as first-line treatment were evaluated.ResultsNumbers of patients with ACC, ASC, ACP, and PDAC were 44 (1.6%), 54 (2.0%), 25 (0.9%), and 2,568 (95.4%), respectively.KRASandTP53mutations were prevalent in ASC, ACP, and PDAC (90.7/85.2, 76.0/68.0, and 85.1/69.1%, respectively), while their rates were both significantly lower in ACC (13.6/15.9%, respectively). Conversely, the rate of homologous recombination-related (HRR) genes, includingATMandBRCA1/2,was significantly higher in ACC (11.4/15.9%) than PDAC (2.5/3.7%). In ASC and ACP, no significant differences in ORR, DCR, or TTF between FFX and GnP were noted, while ACC patients showed a trend toward higher ORR with FFX than GnP (61.5 vs. 23.5%,p = 0.06) and significantly more favorable TTF (median 42.3 vs. 21.0 weeks, respectively,p = 0.004).ConclusionsACC clearly harbors different genomics compared with PDAC, possibly accounting for differences in treatment efficacy.
Juvenile vervet monkeys rely on others when responding to danger
Authors: Mohr Tecla , van de Waal Erica , Zuberbühler Klaus , Mercier Stéphanie 
Published: April 2023

AbstractPrimate alarm calls are mainly hardwired but individuals need to adapt their calling behaviours according to the situation. Such learning necessitates recognising locally relevant dangers and may take place via their own experience or by observing others. To investigate monkeys alarm calling behaviour, we carried out a field experiment in which we exposed juvenile vervet monkeys to unfamiliar raptor models in the presence of audiences that differed in experience and reliability. We used audience age as a proxy for experience and relatedness as a proxy for reliability, while quantifying audience reactions to the models. We found a negative correlation between alarm call production and callers’ age. Adults never alarm called, compared to juveniles. We found no overall effect of audience composition and size, with juveniles calling more when with siblings than mothers or unrelated individuals. Finally, concerning audience reactions to the models, we observed juveniles remained silent with vigilant mothers and only alarm called with ignoring mothers, whereas we observed the opposite for siblings: juveniles remained silent with ignoring siblings and called with vigilant siblings. Despite the small sample size, juvenile vervet monkeys, confronted with unfamiliar and potentially dangerous raptors, seem to rely on others to decide whether to alarm call, demonstrating that the choice of the model may play an important key role in the ontogeny of primate alarm call behaviour.
Differential responses to con- and allospecific visual cues in juvenile ravens (Corvus corax): the ontogeny of gaze following and social predictions
Authors: Zeiträg Claudia , Osvath Mathias 
Published: April 2023

AbstractGaze following refers to the ability to co-orient with others’ gaze directions. Ontogenetic studies on gaze following in animals have predominantly used human experimenters as demonstrators. It is, however, likely that developing animals are initially more attuned to individuals from their own species, which might result in differences in the ontogenetic onset of gaze following with human and conspecific demonstrators. “Checking back” is a signature behaviour in the gaze following repertoires of humans, apes, and some Old world monkeys. It is commonly interpreted as a representation of the referentiality of gaze and is thus diagnostic of social predictions. Recently, “checking back” has been discovered in four avian species, suggesting a shared skill among birds. To investigate effects of con- and allospecific demonstrators on gaze following responses, we studied visual co-orientations of four hand-raised juvenile common ravens (Corvus corax) with human and conspecific gaze cues. Moreover, we for the first time investigated “checking back” in ravens and compared the effects of con- and allospecific demonstrators on this behaviour. Ravens followed human and conspecific gaze with no apparent differences in ontogenetic onset, but after significantly longer latencies with human demonstrators. Subjects moreover already checked back at 30 days old and did so significantly more often with conspecific demonstrators. Our findings suggest differences in processing speed and social predictions of human and conspecific gazes, indicating an underlying neurocognitive mechanism attuned to social information gathering from conspecifics. We propose more studies using conspecific demonstrators to reveal the full gaze following potential of a species.
The varieties of bifocal Grassmann tensors
Authors: Bertolini Marina , Bini Gilberto , Turrini Cristina 
Published: April 2023

AbstractGrassmann tensors arise from classical problems of scene reconstruction in computer vision. In particular, bifocal Grassmann tensors, related to a pair of projections from a projective space onto view spaces of varying dimensions, generalize the classical notion of fundamental matrices. In this paper, we study in full generality the variety of bifocal Grassmann tensors focusing on its birational geometry. To carry out this analysis, every object of multi-view geometry is described both from an algebraic and geometric point of view, e.g., the duality between the view spaces, and the space of rays is explicitly described via polarity. Next, we deal with the moduli of bifocal Grassmann tensors, thus showing that this variety is both birational to a suitable homogeneous space and endowed with a dominant rational map to a Grassmannian.
The social vulnerability index as a risk stratification tool for health disparity research in cancer patients: a scoping review
Authors: Tran Tiffaney , Rousseau Morgan A. , Farris David P. , Bauer Cici , Nelson Kelly C. , Doan Hung Q. 
Published: April 2023

AbstractPurposeThe social vulnerability index (SVI), developed by the Centers for Disease Control and Prevention, is a novel composite measure encompassing multiple variables that correspond to key social determinants of health. The objective of this review was to investigate innovative applications of the SVI to oncology research and to employ the framework of the cancer care continuum to elucidate further research opportunities.MethodsA systematic search for relevant articles was performed in five databases from inception to 13 May 2022. Included studies applied the SVI to analyze outcomes in cancer patients. Study characteristics, patent populations, data sources, and outcomes were extracted from each article. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultsIn total, 31 studies were included. Along the cancer care continuum, five applied the SVI to examine geographic disparities in potentially cancer-causing exposures; seven in cancer diagnosis; fourteen in cancer treatment; nine in treatment recovery; one in survivorship care; and two in end-of-life care. Fifteen examined disparities in mortality.ConclusionIn highlighting place-based disparities in patient outcomes, the SVI represents a promising tool for future oncology research. As a reliable geocoded dataset, the SVI may inform the development and implementation of targeted interventions to prevent cancer morbidity and mortality at the neighborhood level.
The Use of Stem Cells as a Potential Treatment Method for Selected Neurodegenerative Diseases: Review
Authors: Cecerska-Heryć Elżbieta , Pękała Maja , Serwin Natalia , Gliźniewicz Marta , Grygorcewicz Bartłomiej , Michalczyk Anna , Heryć Rafał , Budkowska Marta , Dołęgowska Barbara 
Published: April 2023

AbstractStem cells have been the subject of research for years due to their enormous therapeutic potential. Most neurological diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are incurable or very difficult to treat. Therefore new therapies are sought in which autologous stem cells are used. They are often the patient's only hope for recovery or slowing down the progress of the disease symptoms. The most important conclusions arise after analyzing the literature on the use of stem cells in neurodegenerative diseases. The effectiveness of MSC cell therapy has been confirmed in ALS and HD therapy. MSC cells slow down ALS progression and show early promising signs of efficacy. In HD, they reduced huntingtin (Htt) aggregation and stimulation of endogenous neurogenesis. MS therapy with hematopoietic stem cells (HSCs) inducted significant recalibration of pro-inflammatory and immunoregulatory components of the immune system. iPSC cells allow for accurate PD modeling. They are patient—specific and therefore minimize the risk of immune rejection and, in long-term observation, did not form any tumors in the brain. Extracellular vesicles derived from bone marrow mesenchymal stromal cells (BM-MSC-EVs) and Human adipose-derived stromal/stem cells (hASCs) cells are widely used to treat AD. Due to the reduction of Aβ42 deposits and increasing the survival of neurons, they improve memory and learning abilities. Despite many animal models and clinical trial studies, cell therapy still needs to be refined to increase its effectiveness in the human body.Graphical Abstract
Absorptive capacity in family firms: a systematic literature review
Authors: Pütz Laura , Werner Arndt 
Published: April 2023

AbstractTwo-thirds of all businesses worldwide are family firms. For these family firms, absorptive capacity (AC) is key to acquiring, assimilating, transforming, and exploiting new, external knowledge for purposes of value creation. In this study, we conduct a literature review to obtain an overview of the existing research on AC in family firms. Drawing on 27 articles, we show that because of the family members’ induced influence on the family firm, the findings from previous studies based on non-family businesses cannot be applied to family businesses. In fact, we demonstrate that this influence can even create ambiguous effects on the integration of AC into the firm. The results of our literature review indicate that on the one hand, family members promote the integration of external knowledge, that is, they utilize their family-specific resources. On the other hand, tapping on such family-specific resources can simultaneously cause family firms to isolate themselves and restrict the firm’s access to external knowledge. Our analysis also reveals that research on AC in family firms is mostly conducted on a conceptual level and that the few empirical studies usually draw on simple, one-dimensional constructs. Thus, we encourage more future empirical research to draw on the multidimensional constructs of AC and family influence.
Combined tubular adenocarcinoma, neuroendocrine carcinoma and adenocarcinoma with enteroblastic differentiation arising in Barrett esophagus
Authors: Sugawara Kotaro , Fukuda Takashi , Kishimoto Yutaka , Oka Daiji , Kawashima Yoshiyuki , Inoshita Naoko , Kanda Hiroaki 
Published: April 2023

AbstractAdenocarcinoma (AC) with neuroendocrine carcinoma (NEC) or enteroblastic (ENT) differentiation rarely develops in Barrett’s esophagus (BE). A 76-year-old man was diagnosed with Barrett’s AC (cT1bN0M0) and underwent thoracoscopic esophagectomy. A type 0-IIc + 0-Is lesion measuring 26 × 21 mm was macroscopically observed on a background of long segment BE (pT1bN0M0). The tumor comprised three different histological types of carcinoma (NEC, AC with ENT differentiation and moderately differentiated AC). NEC showed positivity for synaptophysin, chromogranin A and insulinoma-associated protein 1 with a Ki-67 index of 60.6%. ENT tumors were immunopositive for AFP and sal-like protein 4, and focally immunopositive for human chorionic gonadotrophin. The amounts of NEC, ENT and AC were 40%, 40% and 20%, respectively. p53 expression was positive throughout the tumor. Rb expression was negative at the NEC, but positive at the ENT and AC. CD4 and CD8 densities were lower in the NEC segment than in the AC and ENT segments, and PD-L1 expression was negative throughout the tumor. Early cancer arising in BE with a combination of tubular AC, ENT tumors and NEC is very rare. Our observations might contribute to understanding the carcinogenetic pathways and tumor microenvironment of NEC and ENT tumors.
Human–Robot Cooperation in Economic Games: People Show Strong Reciprocity but Conditional Prosociality Toward Robots
Authors: Hsieh Te-Yi , Chaudhury Bishakha , Cross Emily S. 
Published: April 2023

AbstractUnderstanding how people socially engage with robots is becoming increasingly important as these machines are deployed in social settings. We investigated 70 participants’ situational cooperation tendencies towards a robot using prisoner’s dilemma games, manipulating the incentives for cooperative decisions to be high or low. We predicted that people would cooperate more often with the robot in high-incentive conditions. We also administered subjective measures to explore the relationships between people’s cooperative decisions and their social value orientation, attitudes towards robots, and anthropomorphism tendencies. Our results showed incentive structure did not predict human cooperation overall, but did influence cooperation in early rounds, where participants cooperated significantly more in high-incentive conditions. Exploratory analyses further revealed that participants played a tit-for-tat strategy against the robot (whose decisions were random), and only behaved prosocially toward the robot when they had achieved high scores themselves. These findings highlight how people make social decisions when their individual profit is at odds with collective profit with a robot, and advance understanding on human–robot interactions in collaborative contexts.
The ideal test for the divergence of a series
Authors: Filipów Rafał , Kwela Adam , Tryba Jacek 
Published: April 2023

AbstractWe generalize the classical Olivier’s theorem which says that for any convergent series $$\sum _n a_n$$

∑
n

a
n

with positive nonincreasing real terms the sequence $$(n a_n)$$

(
n

a
n

)

tends to zero. Our results encompass many known generalizations of Olivier’s theorem and give some new instances. The generalizations are done in two directions: we either drop the monotonicity assumption completely or we relax it to the monotonicity on a large set of indices. In both cases, the convergence of $$(na_n)$$

(
n

a
n

)

is replaced by ideal convergence. In the second part of the paper, we examine families of sequences for which the assertions of our generalizations of Olivier’s theorem fail. Here, we are interested in finding large linear and algebraic substructures in these families.
Electrochromic-Induced Rechargeable Aqueous Batteries: An Integrated Multifunctional System for Cross-Domain Applications
Authors: Zhao Qi , Pan Zhenghui , Liu Binbin , Bao Changyuan , Liu Ximeng , Sun Jianguo , Xie Shaorong , Wang Qing , Wang John , Gao Yanfeng 
Published: April 2023

Abstract
Multifunctional electrochromic-induced rechargeable aqueous batteries (MERABs) integrate electrochromism and aqueous ion batteries into one platform, which is able to deliver the conversion and storage of photo-thermal-electrochemical sources. Aqueous ion batteries compensate for the drawbacks of slow kinetic reactions and unsatisfied storage capacities of electrochromic devices. On the other hand, electrochromic technology can enable dynamically regulation of solar light and heat radiation. However, MERABs still face several technical issues, including a trade-off between electrochromic and electrochemical performance, low conversion efficiency and poor service life. In this connection, novel device configuration and electrode materials, and an optimized compatibility need to be considered for multidisciplinary applications. In this review, the unique advantages, key challenges and advanced applications are elucidated in a timely and comprehensive manner. Firstly, the prerequisites for effective integration of the working mechanism and device configuration, as well as the choice of electrode materials are examined. Secondly, the latest advances in the applications of MERABs are discussed, including wearable, self-powered, integrated systems and multisystem conversion. Finally, perspectives on the current challenges and future development are outlined, highlighting the giant leap required from laboratory prototypes to large-scale production and eventual commercialization.
Ionic Liquid Assisted Imprint for Efficient and Stable Quasi-2D Perovskite Solar Cells with Controlled Phase Distribution
Authors: Peng Haibin , Li Dengxue , Li Zongcai , Xing Zhi , Hu Xiaotian , Hu Ting , Chen Yiwang 
Published: April 2023

AbstractAlthough two-dimensional perovskite devices are highly stable, they also lead to a number of challenges. For instance, the introduction of large organic amines makes crystallization process complicated, causing problems such as generally small grain size and blocked charge transfer. In this work, imprint assisted with methylamine acetate were used to improve the morphology of the film, optimize the internal phase distribution, and enhance the charge transfer of the perovskite film. Specifically, imprint promoted the dispersion of spacer cations in the recrystallization process with the assistance of methylamine acetate, thus inhibited the formation of low-n phase induced by the aggregation of spacer cations and facilitated the formation of 3D-like phase. In this case, the corresponding quasi-2D perovskite solar cells delivered improved efficiency and exhibited superior stability. Our work provides an effective strategy to obtain uniform phase distribution for quasi-2D perovskite.