bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data
Authors: Abiri Arash , Nguyen Theodore V. , Chen Haidee , Krippaehne Elise , Lerner David K. , Rahman Arifeen S. , Roozdar Pooya , Rosvall Brandon R. , Sabbaj Michael , Workman Alan D. , Wu Shannon , Adappa Nithin D. , Beswick Daniel M. , Chang Eugene H. , Chang Michael T. , Choby Garret , Eide Jacob G. , Douglas Jennifer E. , Geltzeiler Mathew , Kohanski Michael A. , Hwang Peter H. , Le Christopher H. , Lee Jivianne T. , Nayak Jayakar V. , Palmer James N. , Patel Zara M. , Pinheiro‐Neto Carlos D. , Resnick Adam C. , Smith Timothy L. , Snyderman Carl H. , John Maie A. St , Storm Phillip B. , Suh Jeffrey D. , Wang Marilene B. , Wang Eric W. , Kuan Edward C. 
Published: January 2025

ABSTRACTBackgroundOlfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of the anterior cranial fossa. Surgery can be performed with unilateral or bilateral resection depending on extent of involvement; however, there are currently no studies comparing outcomes between the two.MethodsProspective and retrospective data on primary ONB patients were collected from a multicenter registry involving eight academic sites. Propensity score matching (PSM) was used to create patient cohorts with similar baseline characteristics. Cox proportional hazards and Kaplan Meier analyses assessed overall survival (OS). Logistic regression assessed associations between extent of resection (unilateral versus bilateral) and tumor recurrence or postoperative cerebrospinal fluid (CSF) leak.ResultsA total of 187 ONB patients (47.6% female) with an average age of 53.6 ± 15.1 years were analyzed. Most tumors were unilateral (81.3%) and predominantly Kadish C (58.3%) or Hyams II (55.8%). Overall, 56.7% of patients underwent bilateral resection. Fifty‐four patients experienced tumor recurrence and nine had postoperative CSF leaks. Following PSM (n = 45/group), extent of resection was not associated with mortality (hazard ratio [HR] 1.73; p = 0.407) or OS (p = 0.400). There was no association between extent of resection and recurrence (odds ratio [OR] 0.90; p = 0.814) or postoperative CSF leak (OR 1.54; p = 0.647).ConclusionsFor ONB tumors where unilateral resection may be feasible and oncologically sound, the decision for unilateral versus bilateral resection showed no significant effect on survival, recurrence, or postoperative CSF leak. Oncologic outcomes may be comparable when resection is tailored to individual patient and tumor characteristics.
Nonclassical Optical Response of Particle Plasmons With Quantum‐Informed Local Optics
Authors: Ye Weixiang 
Published: January 2025

AbstractAs the dimensions of plasmonic structures or the field confinement length approach the mean free path of electrons, mesoscopic optical response effects, including nonlocality, electron spill‐in or spill‐out, and Landau damping, are expected to become observable. In this work, a quantum‐informed local analogue model (QILAM) that maps these nonclassical optical responses onto a local dielectric film is presented. The primary advantage of this model lies in its compatibility with the highly efficient boundary element method (BEM), which includes retardation effects with relatively large particle sizes. Furthermore, the approach offers a unified framework that connects two important semiclassical theories: the generalized nonlocal optical response (GNOR) theory and the Feibelman d‐parameters formalism. It is envisioned that QILAM can evolve into a multiscale electrodynamic tool for exploring nonclassical optical responses in diverse plasmonic structures in the future. This can be achieved by directly translating mesoscopic effects into observable phenomena, such as plasmon resonance energy shifts and linewidth broadening in the scattering spectrum.
Silicone Rheological Properties for Material Extrusion Additive Manufacturing
Authors: Liu Wenbo , Peeke Lachlan M. , Lu Tingxi , Han Aijie , Hickner Michael A. 
Published: January 2025

ABSTRACTAdditive manufacturing (AM), known as three‐dimensional (3D) printing, uses computer‐controlled materials deposition to fabricate 3D objects by selectively depositing materials, usually in a layer‐wised fashion, to build a 3D object using free‐form fabrication. Integrating silicone elastomers with AM deposition strategies has been of interest due to the important application characteristics of silicones such as excellent mechanical properties, thermal resistance, and chemical inertness. This work presents a study on the shear‐thinning properties of thermally‐curable liquid silicone feedstocks to describe ideal flow and shape‐retention properties for direct ink writing of liquid silicone rubbers. To complement the direct ink writing process developed in this work for silicone AM, flow properties of various silicone feedstocks were identified through measurement of rheological properties using the AM fluid dispenser under various pressures, supported by parallel plate oscillatory shear rheology. A systematic process for evaluating and investigating the AM performance of seven different grades of silicones is introduced. The shape retention, overhang, and dimensional accuracy of these silicones in 3D printing process have been compared and summarized. This systematic evaluation methodology can be applied for silicone material selection and printing of silicone parts with complicated architectures.
Asynchronous passive control under event‐triggered scheme for discrete‐time Markov jump systems with complex probabilities
Authors: Li Hongchao , Liu Yang , Liu Jiao , Xu Wenli 
Published: January 2025

AbstractThis paper deals with the asynchronous passive control based on event‐triggered scheme for Markov jump systems with complex probabilities. A hidden Markov model with uncertain and unknown conditional probabilities is presented to describe the asynchronization. The complex probabilities consider that both transition probability matrix and conditional probability matrix in hidden Markov model contain uncertain and unknown elements simultaneously, with the former governing the jump of system mode and the latter representing the asynchronous relation between the system mode and the controller mode. Asynchronous control strategies based on hidden Markov model with complex probabilities are proposed under event‐triggered scheme. Furthermore, sufficient conditions are established to guarantee the stochastic passivity, under which the mode‐dependent controller gains and weighting matrices in the event‐triggered scheme are co‐designed. Theoretical results are finally verified via an example.
Balancing Priorities: A Configurational Framework to Achieve Strategic Benefits From Sustainable Industry 4.0 Enablers in Operations and Supply Chain
Authors: Caiado Rodrigo Goyannes Gusmão , Santos Renan Silva , Schery Carlos Alejandro Días , Scavarda Luiz Felipe , Garza‐Reyes Jose Arturo 
Published: January 2025

AbstractThis study delves into the intricate integration of Industry 4.0 (I4.0) and sustainability within the realm of Operations and Supply Chain Management (OSCM), introducing a pioneering Sustainable I4.0‐enabled OSCM (S‐OSCM4.0) framework. From the lens of the dynamic capabilities view (DCV) and social exchange theory (SET), this research proposes a configurational framework using the CIMO logic—Context, Intervention, Mechanism and Outcome—to achieve strategic benefits from S‐OSCM4.0 enablers, specifically focusing on developing countries. Employing an empirical study with hybrid fuzzy multi‐criteria decision‐making methods, the study endeavours to delineate the prioritisation sequence for implementing pivotal enablers and subsequently realising the benefits of S‐OSCM4.0, aligned with the 2030 agenda. The proposed framework offers a novel, integrative approach by combining DCV and SET within the CIMO logic, providing a robust, context‐specific roadmap for Sustainable I4.0‐enabled OSCM. It advances theory by bridging I4.0 and sustainability in OSCM for the digital transformation of developing countries.
The BAM‐GelMA‐ADSCs bilayer patch promotes tissue regeneration and functional recovery after large‐area bladder defects in beagles
Authors: An Ziyan , Wang Pengchao , Ling Zhengyun , Bi Kaipeng , Wang Zheng , Shao Jinpeng , Zhao Jian , Fu Zhouyang , Huang Meng , Wei Wenjie , Xiao Shuwei , Zhou Jin , Fu Weijun 
Published: January 2025

AbstractPrevious studies of bladder tissue engineering simply seeded cells onto the surface of the material, which makes the cells lack protection and makes it difficult to face the complex in vivo environment. The gelatin methacryloyl (GelMA) hydrogel possesses outstanding biocompatibility and distinctive photo‐crosslinking characteristics and is capable of offering a suitable three‐dimensional growth environment for cells. This study explored the optimal concentration of GelMA for encapsulating adipose‐derived stem cells (ADSCs) and combined it with bladder acellular matrix (BAM) to create a tissue‐engineered bladder patch. Results indicated that 10% GelMA more effectively promoted ADSCs proliferation and spreading compared to 7.5% and 12.5% concentrations, which can offer a better extracellular matrix environment for cells. BAM performed as an excellent substrate with mechanical properties and stitchability similar to natural tissues. Animal experiments demonstrated that the encapsulated ADSCs in GelMA enhanced patch vascularization in vivo and BAM‐GelMA‐ADSCs tissue‐engineered bladder patch can repair large‐scale bladder defects in beagles and promote bladder tissue regeneration and functional recovery. This photocrosslinking hydrogel‐acellular matrix patch provides a protective semi‐controlled environment for ADSCs, supporting the growth and viability of encapsulated cells in vivo, while being easy to suture and preventing leakage, and has significant clinical potential.
Biologically‐oriented alveolar ridge preservation to correct bone dehiscence at immediate implant placement
Authors: Trombelli Leonardo , Grenzi Tommaso 
Published: January 2025

AbstractBackgroundThe purpose of the present case study is to describe the application of a modification of the Biologically‐oriented Alveolar Ridge Preservation (BARP) principles in cases of peri‐implant bone dehiscence (PIBD) due to a compromised alveolus at immediate implant placement (IIP).MethodsThe technique is based on the stratification of three layers: a deep layer with a collagen sponge (CS) in the apical part of the alveolus (where the buccal bone plate was still present) to support the blood clot; a graft layer to correct the PIBD; and a superficial collagen layer to cover the graft thus providing space and enhancing clot/graft stability. Healing was obtained by primary closure.ResultsAt the re‐entry procedure for implant uncovering, a complete PIBD correction with newly formed peri‐implant bone up to the level of the polished collar was observed in both cases.ConclusionsThese observations suggest that BARP based on the combined use of CS and deproteinized bovine bone mineral may be regarded as a simplified treatment option to correct a PIBD at IIP.Key points
Why treat a Peri‐Implant Bone Dehiscence (PIBD)? PIBD should be treated to avoid biological and esthetic complications over time.
What plays a key role in this case? The stability of both the graft and the cloth is essential for providing space for bone formation to correct the PIBD; the extraction socket supports angiogenic and osteogenic properties; Primary intention closure is crucial to prevent potential infection.
Limitation: the efficacy of the technique must be assessed.
Plain Language SummaryThis case study described the potential to correct a post‐extraction osseous defect associated with a substantial portion of a dental implant which resulted exposed and without bone support on its buccal aspect. The application of a novel bone augmentation technique, namely the biologically oriented Alveolar Ridge Preservation, has been described. This simplified procedure is based on the stratification of i) a deep collagen layer in the apical part of the socket to support the blood clot and spontaneous bone formation, ii) a graft of bone substitute to correct the missing bone, and iii) a superficial collagen layer to protect the graft and the wound. After 5 months, a complete correction of the osseous defect with newly formed bone up to the head of the implant was observed in both treated cases.
Transport und Nutzung von flüssigem Wasserstoff: Leitprojekt TransHyDE – Projekt AppLHy!1)
Authors: Fuhry Franziska , Neumann Holger , Weiss Klaus‐Peter , Wolf Michael J. 
Published: January 2025

ZusammenfassungDieser Artikel behandelt Technologien zu Bereitstellung, Speicherung, Transport und Anwendung von flüssigem Wasserstoff (LH2) und seinem Nutzen für den Aufbau einer Wasserstoff‐Transport‐Infrastruktur in Deutschland. LH2 bietet durch seine hohe gravimetrische Energiedichte und intrinsische Reinheit große Potenziale innerhalb einer nachhaltigen Wasserstoffwirtschaft. Zudem entstehen Synergieeffekte zwischen dem tiefkalten LH₂ und Hochtemperatur‐Supraleitern (HTS), und auch für andere Prozesse lässt sich die „Kälteleistung“ von LH₂ nutzen.
Assessing candidate DLX‐regulated genes in the first pharyngeal arch of chick embryos
Authors: Sohail Afshan , Nicoll Olivia , Bendall Andrew J. 
Published: January 2025

AbstractBackgroundInsights into the development and evolution of asymmetrical jaws will require an understanding of the gene regulatory networks that underpin the differential morphogenesis of the maxillary and mandibular domains of the first pharyngeal arch in a variety of gnathostomes. While a robust relationship has been demonstrated between jaw patterning and the Endothelin‐Dlx gene axis, much less is known of the next level of genes in the jaw patterning hierarchy.ResultsSeveral genes, whose expression depends on Dlx5 and/or Dlx6, have been identified in mice. Here, we examined the expression patterns of the chick orthologues of some of those genes, namely GSC, PITX1, HAND2, and GBX2, and tested their dependence on endothelin signaling to assess whether there is a conserved regulatory relationship between those genes in the chick embryo. To further validate these genes as direct DLX targets, we identified conserved non‐coding sequences containing candidate DLX binding motifs and demonstrated DLX‐responsiveness in vitro.ConclusionsThe evidence presented in this study combines to support the hypothesis that these four genes are direct targets of DLX transcription factors in the lower jaw‐forming tissue.
Impact of optimal secondary cytoreductive surgery on survival outcomes in women with recurrent endometrial carcinoma: A systematic review and meta‐analysis
Authors: Raffone Antonio , Pellecchia Giulia , Pregnolato Sara , Raimondo Diego , Travaglino Antonio , Neola Daniele , Driul Lorenza , Scambia Giovanni , Arcieri Martina , Vastarella Maria Giovanna , Cobellis Luigi , Restaino Stefano , Vizzielli Giuseppe 
Published: January 2025

AbstractBackgroundManagement of recurrent endometrial carcinoma (EC) represents a challenge. Although a complete resection of visible disease at secondary surgery (R0) is recommended, the impact of R0 on survival outcomes is unclear and pooled data are lacking.ObjectiveTo quantitatively assess the impact of R0 on survival outcomes in women with EC recurrence.Search StrategyA systematic review and meta‐analysis was performed searching eight electronic databases from their inception up to January 2024.Selection CriteriaAll peer‐reviewed studies that assessed quantitatively the impact of R0 on survival outcomes in women at first EC recurrence were included.Data Collection and AnalysisHazard ratio (HR) with 95% confidence interval (CI) for death of any cause and secondary recurrent or progressive disease in women with EC recurrence who underwent R0 compared to non‐optimal secondary surgical cytoreduction (R1) were pooled and assessed at both univariable and multivariable analyses.Main ResultsThree studies with 442 patients were included. At univariate analysis, in women with EC recurrence and R0 compared to women with EC recurrence and R1, pooled HR was 0.451 (95% CI: 0.319–0.638) for death from any cause, and 0.517 (95% CI: 0.298–0.895; p = 0.019) for recurrent or progressive disease.At multivariate analysis, in women with EC recurrence and R0 compared to women with EC recurrence and R1, pooled HR was 0.447 (95% CI: 0.255–0.783; p = 0.005) for death from any cause, and 0.585 (95% CI: 0.359–0.952; p = 0.031) for recurrent or progressive disease.ConclusionIn women with EC recurrence, R0 is an independent prognostic factor, decreasing the risk of death from any cause by approximatively 55%, and of recurrent or progressive disease by approximatively 40%, compared to R1.
Immediate skin‐to‐skin contact and postpartum hemorrhagic morbidity
Authors: Wiley Rachel L. , Ghose Ipsita , Canfield Dana R. , Sarker Minhazur R. , Mendez‐Figueroa Hector , Chauhan Suneet 
Published: January 2025

AbstractObjectiveTo examine rates of postpartum hemorrhagic (PPH) morbidity among patients who did and did not have immediate skin‐to‐skin contact (SSC).MethodsThis study was a retrospective cohort of all non‐anomalous, term singleton vaginal births at a Level IV center over 2 years. Exclusion criteria included COVID‐19. Immediate SSC was defined as at least 60 min of direct contact initiated between parturient and neonate within 10 min of birth. The primary outcome was a composite of maternal morbidity related to PPH compared among those with and without immediate SSC. We used multivariable Poisson regression adjusted for possible confounders with robust error variance to determine the strength of the association.ResultsOf 8623 deliveries during the study period, 3520 (40.8%) deliveries were included; of which 2428 (55.5%) had immediate SSC and 1028 (31.0%) did not. Immediate SSC reduced the overall rate of composite morbidity (adjusted relative risk 0.78, 95% confidence interval 0.65–0.92), and rate of blood loss 1000 mL or greater, use of additional uterotonics, and use of mechanical tamponade. Blood loss and third stage of labor duration were significantly less for immediate SSC. Transfusion rate and hematocrit change after delivery, did not differ.ConclusionImmediate SSC among term vaginal deliveries was associated with a significant reduction in PPH. Emphasis on early contact for maternal benefit may increase uptake of SSC and provide an accessible intervention for PPH in high‐ and low‐resource settings.
Age did not affect the rate of subsequent hysterectomy following hysteroscopic surgery: A population‐based retrospective cohort study from 2000 to 2020
Authors: Huang Wan‐Ting , Wang Jeng‐Hung , Ding Dah‐Ching 
Published: January 2025

AbstractObjectivePrevious studies found younger age was associated with an increased risk of hysterectomy after hysteroscopic surgeries (HS) due to abnormal uterine bleeding (AUB). The present study aimed to evaluate the effect of age on the incidence of hysterectomy after HS for treating AUB in Taiwan.MethodsThis was a nationwide population‐based retrospective cohort study which utilized the Taiwan National Health Insurance Database. The present study involved 4150 participants who underwent HS due to AUB. The study focused on females aged ≥40 years diagnosed with AUB who underwent HS between 2000 and 2020. Hysterectomy outcomes were analyzed using the Cox proportional hazards model, and age was categorized into three groups (40–44, 45–49, and 50–55 years). Statistical significance was set at P < 0.05.ResultsThis study involved 4150 participants with an average age of 46.1 years, categorized into the following age groups: 40–44 years (39.6%), 45–49 years (38.8%), and 50–55 years (21.6%). Approximately 8.1% of participants required hysterectomy treatment; the highest incidence was observed in the 40–44‐year age group (8.6%). The median time from HS to hysterectomy varied across age groups, ranging from 0.25–2.78 years. The presence of uterine myoma (adjusted hazard ration [aHR]: 2.11; 95% CI: 1.70–2.64; P < 0.0001) and adenomyosis (aHR: 10.24; 95% CI: 8.17–12.85; P < 0.0001) significantly increased the risk of hysterectomy. Kaplan–Meier survival curves demonstrated a comparable likelihood of hysterectomy across age groups within 5 years post‐HS, with most occurrences occurring in the initial 5 years.ConclusionOur study found no age effect on subsequent hysterectomy after HS. This study contributes to a significant understanding of HS outcomes, aiding information for patients seeking AUB surgical options.
Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf‐2/HO‐1/NQO1, Ki‐67 and Wnt Signaling Pathways
Authors: Öztürk Ayşe Betül , Akaras Nurhan , Şimşek Hasan , Kandemir Fatih Mehmet 
Published: January 2025

ABSTRACTOvarian ischemia is a pathological condition that usually occurs due to ovarian torsion, resulting in the interruption of blood supply to the ovaries and oxygen deficiency. Silymarin (SLM) is a flavonoid complex of plant origin with pharmacological properties such as antioxidant, anti‐inflammatory, and antiapoptotic effects. In this study, we investigated the effects of SLM through different pathways in rats subjected to experimental ovarian ischemia/reperfusion (I/R). Female Wistar rats were divided into five groups: Control, SLM (50 mg/kg), I/R, I/R + SLM25 (25 mg/kg), and I/R + SLM50 (50 mg/kg). SLM was given orally for 7 days, followed by ischemia (2 h) and reperfusion (2 h) on day 8. Biochemical (MDA, GSH, SOD, CAT, GPx) and histological (H&E, Ki‐67 IHC) analyses were performed. Also, molecular (qRT‐PCR) analyses were performed to evaluate oxidative stress, inflammation, apoptosis, and Wnt signaling. I/R increased MDA and NO levels in ovarian tissue while decreasing SOD, CAT, GPx, and GSH. Antioxidant defense genes (Nrf‐2, HO‐1, NQO1) were suppressed, and inflammation markers (NF‐ĸB, IL‐1β, TNF‐α) along with apoptotic markers (Bax, Caspase‐3) were elevated, while Bcl‐2 decreased. The Wnt signaling pathway was inhibited, particularly at Wnt‐3A, LRP5, Dvl‐2, and Cyclin‐1, reducing Ki‐67 protein levels and IHC positivity. Silymarin has shown a therapeutic effect on ovarian ischemia reperfusion injury with its antioxidant, antiapoptotic and anti‐inflammatory effects and cell cycle regulatory activity.