bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive differential evolution algorithm with a pheromone-based learning strategy for global continuous optimization
Authors: Singsathid Pirapong , Puphasuk Pikul , Wetweerapong Jeerayut 
Published: July 2023

AbstractDifferential evolution algorithm (DE) is a well-known population-based method for solving continuous optimization problems. It has a simple structure and is easy to adapt to a wide range of applications. However, with suitable population sizes, its performance depends on the two main control parameters: scaling factor (F) and crossover rate (CR). The classical DE method can achieve high performance by a time-consuming tunning process or a sophisticated adaptive control implementation. We propose in this paper an adaptive differential evolution algorithm with a pheromone-based learning strategy (ADE-PS) inspired by ant colony optimization (ACO). The ADE-PS embeds a pheromone-based mechanism that manages the probabilities associated with the partition values ofFandCR. It also introduces a resetting strategy to reset the pheromone at a specific time to unlearn and relearn the progressing search. The preliminary experiments find a suitable number of subintervals (ns) for partitioning the control parameter ranges and the reset period (rs) for resetting the pheromone. Then the comparison experiments evaluate ADE-PS using the suitablensandrsagainst some adaptive DE methods in the literature. The results show that ADE-PS is more reliable and outperforms several well-known methods in the literature.
Competency-based medical curriculum: Exploring the preclinical medical teachers’ pedagogical and technical readiness levels
Authors: APRAJITA  , GUPTA RAKESH KUMAR , MOHAN MAMTA 
Published: July 2023

BackgroundThe medical curriculum for undergraduates was revised by the Medical Council of India in 2019, after 21 years. We did this study to determine teachers’ pedagogical and technical readiness to implement the competency-based curriculum in medical colleges and determine factors that affect readiness, from their perspective.MethodsWe conducted a cross-sectional survey in the form of an online questionnaire. The qualitative data were coded numerically and were analysed using frequencies and proportions. Pearson Chi-square test was used to study the association among variables.ResultsThe majority (85%) of respondents had attended a curriculum implementation training programme; 62.2% with experience <5 years, 56.1% with experience 5–10 years and a minority of 13.3% with >10 years’ experience were ready to a ‘great extent’ to implement the new curriculum; 54.1% agreed to re-frame lectures and 64.9% possessed technological skills to suit the needs of a competency-based curriculum. About 77% agreed that it will provide a rich learning environment, inspire self-directed learning while 52% believed it will promote scientific thinking and provide better learning outcomes in the long run.ConclusionMedical teachers had a positive attitude towards implementation of the new curriculum. However, numerous factors such as low teacher–student ratio, textbooks designed according to the traditional curriculum, limited teachers’ training and cumbersome paperwork may hinder its successful implementation. Updation of teachers’ knowledge and skills through seminars/workshops is recommended to facilitate delivery of the new curriculum. Like any other ongoing reforms in medical education, competency-based curriculum is a work in process.
HABITUASI MEMBACAKAN BUKU CERITA UNTUK KEAKSARAAN AWAL ANAK USIA DINI
Authors: Hidayah Nur , Handayani Arri , Purnamasari Iin 
Published: July 2023

TK Muslimat NU Masyithoh 04 Kergon Kota Pekalongan yang merupakan lembaga PAUD di Kota Pekalongan yang mempunyai Program kegiatan membacakan buku cerita untuk anak sebagai gerakan keaksaraan awal. Pembelajaran pembiasaan membacakan buku cerita untuk anak sudah diprogramkan dan dilaksanakan oleh guru dan orang tua sejak tahun 2016, namun untuk yang membacakan buku cerita oleh orang tua belum maksimal dan belum dilaksanakan secara rutin karena kesibukan orang tua, membacakan buku cerita anak dikembalikan lagi kepada sekolah. Program pembiasaan ini dilaksanakan setiap pagi yang dilakukan oleh masing-masing guru kelas, tetapi pembiasaan membacakan buku cerita belum berjalan secara optimal karena hanya 1 minggu sekali, pendidik kurang dalam menekuni dalam pembiasaan membacakan buku cerita untuk anak. Maraknya teknologi dan pembelajaran daring sehingga anak sering menggunakan handpone, dan menonton televisi yang ada media gambar bergerak dengan bermacam warna. Salah satu upaya yang dilakukan oleh TK Muslimat NU Masyithoh 04 Kergon adalah dengan kegiatan habituasi atau pembiasan membacakan buku cerita untuk keaksaraan awal pada anak usia dini. Tujuan dari penelitian ini adalah untuk menganalisis habituasi membacakan buku cerita untuk keaksaraan awal anak usia dini. Tempat Penelitian adalah di TK Muslimat NU Masyithoh 04 Kergon Jalan Sulawesi Gg 3 No. 15 Kelurahan Bendan Kergon Kecamatan Pekalongan Barat Kota Pekalongan. Waktu pelaksanaan penelitian adalah bulan April – Juni 2022. Subyek yaitu pendidik yang berjumlah 5 dan 1 kepala sekolah. Penelitian ini yang diteliti adalah aktivitas guru dalam habituasi membacakan buku cerita untuk keaksaraan awal anak usia dini bagaimana. Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologsi yaitu melihat fenomena yang terjadi dan tindakan apa yang dilakukan untuk kegiatan tersebut. Teknik pengumpulan data mengumpulkan data adalah dengan menggunakan observasi, wawancara dan dokumentasi. Habituasi membacakan buku cerita dari pendidik kepada anak didiknya dalam penelitian ini dilakukan secara rutin setiap hari pada pagi hari sebelum pembelajaran inti dengan durasi kurang lebih 30-45 menit. Terdapat pojok-pojok baca di setiap ruangan kelas. Adanya program sedekah buku setiap 1 bulan sekali dari wali murid. Habituasi membacakan buku cerita menambah ketertarikan dan minat baca akan buku sehingga untuk mengenalkan keaksaraan awal anak usia dini disamping itu juga bisa mengembangkan aspek perkembangan bahasa anak dengan baik. Kosa kata anak bertambah, pengenalan literasi dan kegiatan membaca dari kebiasaan yang distimulus oleh pendidik menjadikan keterampilan anak bertambah.
9-PAHSA displays a weak anti-inflammatory potential mediated by specific antagonism of chemokine G protein-coupled receptors
Authors: Wohlfart Paulus , Chehtane Mounir , Luna Ernesto , Mehta Riyaz , Korn Marcus , Konkar Anish , Schwahn Uwe , Petry Stefan , Tennagels Norbert , Bielohuby Maximilian 
Published: July 2023

Introduction: 9-PAHSA belongs to a class of endogenous mammalian bioactive lipids, fatty acid esters of hydroxy fatty acids (FAHFA), that are present in circulation at nanomolar concentrations in mice and humans. Published preclinical data suggest beneficial effects of 9-PAHSA treatment on glucose metabolism as well as modulation of immune function. However, receptor molecules with high affinity towards these lipids have not been identified so far.Methods: In a broad screen of a panel of G protein-coupled receptors (GPCRs) we discovered that 9-PAHSA displays antagonist activity with an IC50 in the micromolar range on selected chemokine receptors, namely, CCR6, CCR7, CXCR4, and CXCR5. The potential immunomodulatory activities in a human cellular model of innate immunity were then investigated.Results and discussion: In our in vitro experiments, a weak anti-inflammatory potential for high concentrations of 9-PAHSA (10–100 µM) could be detected, as treatment reduced the LPS-induced secretion of certain chemokines, such as CXCL10, MIP-1 beta and MCP. Regarding metabolic effects, we re-investigated 9-PAHSA on glucose metabolism and insulin sensitivity in vitro and in mice confirming conclusions from our earlier study that FAHFAs lack glucoregulatory activity following an acute treatment. In conclusion, the specific interactions with a subset of chemokine receptors may contribute to weak anti-inflammatory properties of 9-PAHSA, but further studies are needed to confirm its in anti-inflammatory potential in vivo.
Extra-neural metastases in pediatric diffuse midline gliomas, H3 K27-altered: presentation of two cases and literature review
Authors: De Martino Lucia , Picariello Stefania , Russo Carmela , Errico Maria Elena , Spennato Pietro , Papa Maria Rosaria , Normanno Nicola , Scimone Giuseppe , Colafati Giovanna Stefania , Cacchione Antonella , Mastronuzzi Angela , Massimino Maura , Cinalli Giuseppe , Quaglietta Lucia 
Published: July 2023

IntroductionPediatric diffuse midline gliomas (DMG), H3 K27- altered, are the most aggressive pediatric central nervous system (CNS) malignancies. Disease outcome is dismal with a median survival of less than one year. Extra-neural metastases are an unusual occurrence in DMG and have been rarely described.Methods and resultsHere, we report on two pediatric patients affected by DMG with extra-neural dissemination. Their clinical, imaging, and molecular characteristics are reported here. An 11-year-old male 5 months after the diagnosis of diffuse intrinsic pontine glioma (DIPG) developed metastatic osseous lesions confirmed with computed tomography (CT) guided biopsy of the left iliac bone. The patient died one month after the evidence of metastatic progression. Another 11-year-old female was diagnosed with a cerebellar H3K27- altered DMG. After six months, she developed diffuse sclerotic osseous lesions. A CT-guided biopsy of the right iliac bone was non-diagnostic. She further developed multifocal chest and abdominal lymphadenopathy and pleural effusions. Droplet digital polymerase chain reaction (ddPCR) on pleural effusion revealed the presence of H3.3A mutation (c.83A&gt;T, p.K28M). The patient died 24 months after the diagnosis of DMG and 3 months after the evidence of metastatic pleural effusion.DiscussionExtra-neural metastasis of DMG is a rare event and no standard therapy exists. An accurate and early diagnosis is necessary in order to develop a personalized plan of treatment. Further research is needed to gain further insights into the molecular pathology of DMG, H3K27- altered and improve the quality of life and the final outcome of patients with this deadly disease.
A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments
Authors: Li Xiao-Hua , Pang Wei-Wei , Zhang Yue , Liu Dan-Yang , Yi Qiao-Rong , Wang Ning , Zhang Fu-Rong , Deng Yun , Chen Xiang-Ding , Greenbaum Jonathan , Xiao Hong-Mei , Deng Hong-Wen , Tan Li-Jun 
Published: July 2023

Background: Lipid pathways have been implicated in the pathogenesis of osteoporosis (OP). Lipid-lowering drugs may be used to prevent and treat OP. However, the causal interpretation of results from traditional observational designs is controversial by confounding. We aimed to investigate the causal association between genetically proxied lipid-lowering drugs and OP risk.Methods: We conducted two-step Mendelian randomization (MR) analyses to investigate the causal association of genetically proxied lipid-lowering drugs on the risk of OP. The first step MR was used to estimate the associations of drug target genes expression with low-density lipoprotein cholesterol (LDL-C) levels. The significant SNPs in the first step MR were used as instrumental variables in the second step MR to estimate the associations of LDL-C levels with forearm bone mineral density (FA-BMD), femoral neck BMD (FN-BMD), lumbar spine BMD (LS-BMD) and fracture. The significant lipid-lowering drugs after MR analyses were further evaluated for their effects on bone mineralization using a dexamethasone-induced OP zebrafish model.Results: The first step MR analysis found that the higher expression of four genes (HMGCR, NPC1L1, PCSK9 and PPARG) was significantly associated with a lower LDL-C level. The genetically decreased LDL-C level mediated by the PPARG was significantly associated with increased FN-BMD (BETA = −1.38, p = 0.001) and LS-BMD (BETA = −2.07, p = 3.35 × 10−5) and was marginally significantly associated with FA-BMD (BETA = −2.36, p = 0.008) and reduced fracture risk (OR = 3.47, p = 0.008). Bezafibrate (BZF) and Fenofibric acid (FBA) act as PPARG agonists. Therefore genetically proxied BZF and FBA had significant protective effects on OP. The dexamethasone-induced OP zebrafish treated with BZF and FBA showed increased bone mineralization area and integrated optical density (IOD) with alizarin red staining.Conclusion: The present study provided evidence that BZF and FBA can increase BMD, suggesting their potential effects in preventing and treating OP. These findings potentially pave the way for future studies that may allow personalized selection of lipid-lowering drugs for those at risk of OP.
Analysis of emerging trends and hot spots in respiratory biomechanics from 2003 to 2022 based on CiteSpace
Authors: Huang Xiaofei , Zheng Jiaqi , Ma Ye , Hou Meijin , Wang Xiangbin 
Published: July 2023

Introduction: With the global prevalence of coronavirus disease 2019 (COVID-19), an increasing number of people are experiencing respiratory discomfort. Respiratory biomechanics can monitor breathing patterns and respiratory movements and it is easier to prevent, diagnose, treat or rehabilitate. However, there is still a lack of global knowledge structure in the field of respiratory biomechanics. With the help of CiteSpace software, we aim to help researchers identify potential collaborators and collaborating institutions, hotspots and research frontiers in respiratory biomechanics.Methods: Articles on respiratory biomechanics from 2003 to 2022 were retrieved from the Web of Science Core Collection by using a specific strategy, resulting a total of 2,850 publications. We used CiteSpace 6.1.R6 to analyze the year of publication, journal/journals cited, country, institution, author/authors cited, references, keywords and research trends. Co-citation maps were created to visually observe research hot spots and knowledge structures.Results and discussion: The number of annual publications gradually increased over the past 20 years. Medical Physics published the most articles and had the most citations in this study. The United States was the most influential country, with the highest number and centrality of publications. The most productive and influential institution was Harvard University in the United States. Keall PJ was the most productive author and MCCLELLAND JR was the most cited authors The article by Keall PJ (2006) article (cocitation counts: 55) and the article by McClelland JR (2013) were the most representative and symbolic references, with the highest cocitation number and centrality, respectively. The top keywords were “radiotherapy”, “volume”, and “ventilation”. The top Frontier keywords were “organ motion,” “deep inspiration,” and “deep learning”. The keywords were clustered to form seven labels. Currently, the main area of research in respiratory biomechanics is respiratory motion related to imaging techniques. Future research may focus on respiratory assistance techniques and respiratory detection techniques. At the same time, in the future, we will pay attention to personalized medicine and precision medicine, so that people can monitor their health status anytime and anywhere.
Parental reports on language development in toddlers and preschoolers based on the Croatian version of Communicative Development Inventories III
Authors: Šmit Brleković Lidija , Kuvač Kraljević Jelena 
Published: July 2023

IntroductionPrevious studies have focused on understanding parental attempts to record language development in children, across many typologically different languages. However, many of these studies restricted their assessment to children up to the age of 3 years. The aim of this paper was to move this boundary by examining language development in typically language developed children older than 3 years.MethodsUsing the Croatian version of the Communicative Development Inventories III (CDI-III-HR), we investigated the contribution of parental reports of a child’s lexical, grammatical, and metalinguistic awareness abilities to general language abilities assessed by clinicians. Participants included the parents of 151 children between the ages of 30 to 48 months, who completed the CDI-III-HR and reported on their child’s language abilities.ResultsOur results show that age is significantly associated with the lexical, grammatical, and metalinguistic awareness abilities of a child’s language development. These findings confirm that all three abilities increase with age and that parents can perceive changes in a child’s language development. The subsections of CDI-III-HR were moderately to strongly associated with each other, with the strongest association being between lexicon and grammar, suggesting that they remain closely related after the age of 30 months. Parental assessments of a child’s language development are a better predictor of language production than language comprehension, with grammar making the most consistent and significant contribution.DiscussionThis study confirms that the development of grammatical abilities is the most prominent skill between the ages of 30 to 48 months and that parents can observe the transition in the child’s language development through their usage of grammar in words to grammar in sentences. Based on the selected sample of children, we discovered different patterns of parental success in assessing the child’s language ability. These findings indicate that parents can act as valuable sources of information regarding the child’s language abilities, but clinical assessments of early language development should consider many other formal sources of information in addition to parental reports.
Computational Processes for General Intelligence The SEOM Model
Authors: Balakrishnan Prabhakar 
Published: July 2023

<p>The ‘brain-mind-intelligence’ structure may be considered analogous to a ‘computer-operating system (OS)-application’ construct. Software development would be far more difficult without the benefit of abstractions like file and memory handles, and graphical user interfaces, implemented in operating systems. The easy access to application-level semantics, provided by the infrastructure of the OS, simplifies application development. Abstractions can play a similar role in producing intelligent systems. The power of abstractions may be determined by their ability to unify the treatment of several types of higher concepts. Unifying various concepts in the domain of intelligence, such as problems, solutions, objects, and emotions, through abstractions, will be of immense value. This paper shows how ‘higher-level perceptions’ could be used to serve this objective and construct an OS-like infrastructure. With the infrastructure in place, ordinary software objects developed and deployed using standard methods, become accessible using the semantics provided by the infrastructure. Now, after brief training exercises, the objects would be available for intelligent use. The focus, therefore, is on the design of the infrastructure that could play a mind-like role in humans, using some ideas from philosophers like Kant, Wittgenstein, Heidegger, and Popper.</p>
<p>The design uses a new, non-symbolic, non-connectionist, transmutable method of representation that tackles the so-called ‘frame’ and ‘grounding’ problems of artificial intelligence. The infrastructure enables the conversion of sensory inputs to transmutable representations (amenable to semantic modifications), to flexibly act on software objects developed externally. Furthermore, the infrastructure serves to ground and functionally manage the transmutable, connectionist, and symbolic systems. Thus, the new model plays a critical role in building intelligent systems that overcome major problems in learning and action selection, including brittleness associated with the limited semantics of purely symbolic and connectionist designs. </p>
<p>The new model is then evaluated in terms of features, against criteria set forth independently by Newell, Sun, Vernon, and others. In addition, a new measure of intelligence introduced in this paper is used to quantitatively compare the proposed model with some others developed over the years.</p>
Profil fitokimia dan aktivitas antioksidan dari minyak atsiri kulit buah Jeruk Pontianak (Citrus nobilis lour. var. Microcarpa)
Authors: Wiranda Farianti , Rahayu Ika , Limanto Agus 
Published: July 2023

Buah Citrus nobilis lour. var. microcarpa (C. nobilis) atau buah jeruk pontianak merupakan salah satu sumber makanan dengan kandungan vitamin dan antioksidan yang bagus, sedangkan kulitnya hanya dianggap sebagai limbah. Seiring perkembangan teknologi, kulit jeruk pontianak diolah sehingga minyak atsirinya dapat dimanfaatkan. Penelitian menunjukkan bahwa minyak atsiri kulit buah jeruk Pontianak (C. nobilis) mempunyai kemampuan dalam menghambat pertumbuhan beberapa bakteri positif dan negatif, namun komposisi senyawa, kandungan antioksidan dan antiinflamasi belum banyak dipelajari. Oleh karena itu, tujuan dari penelitian ini adalah mengetahui komposisi senyawa aktif, aktivitas antioksidan dan antiinflamasi minyak atsiri kulit buah C. nobilis. Ekstraksi minyak atsiri kulit buah C. nobilis dilakukan menggunakan metode clavenger. Profil senyawa minyak atsiri didapatkan dengan metode GCMS. Aktivitas antioksidan pada minyak atsiri diuji menggunakan menggunakan radikal 2,2-diphenyl-1-picrylhydrazyl (DPPH). Komponen senyawa aktif dominan pada minyak atsiri C. nobilis adalah limonen, β-myrcene, dan linalool. Minyak atsiri kulit buah C. nobilis memiliki aktivitas antioksidan kuat (IC50 13,114 µg/mL). Aktivitas ini didukung oleh kandungan senyawa aktif yang dominan didalam minyak atsiri tersebut.
KEPARAHAN AKNE VULGARIS DENGAN PENGGUNAAN PROBIOTIK ORAL
Authors: Elvantie  , Widodo Arini Astasari , Hartono Budiman 
Published: July 2023

Latar belakang. Probiotik oral merupakan mikroorganisme yang memiliki berbagai manfaat berdasarkan bukti teori kulit, otak dan usus. Probiotik oral menjadi pilihan yang efektif dalam manajemen akne vulgaris yang telah dibuktikan dengan kajian yang menyatakan probiotik oral mampu menurunkan tingkat derajat akne, lesi inflamasi, lesi non-inflmasi dan menurunkan produksi sebum yang berlebih. Metode. Artikel penelitian yang ditinjau berupa analytical review melalui data base PubMed dan Google Scholar. Hasil. Sebanyak 6 artikel penelitian terpilih yang sesuai dengan tujuan penulisan tinjauan pustaka ini. Kesimpulan.Penggunaan probiotik oral dapat mengurangi lesi inflamasi, derajat keparahan akne vulgaris, total lesi inflamasi serta menurunkan produksi sebum yang berlebihan. Probiotik oral pada beberapa kasus dapat menimbulkan efek samping berupa gangguan gastrointestinal berupa perut kembung. Probiotik diukur dalam unit pembentuk koloni (CFU) yang menunjukkan jumlah sel yang hidup. Konsentrasi dosis pada masing-masing probiotik bervariasi, tetapi probiotik oral tetap memberikan efek yang efektif terhadap tatalaksana akne vulgaris.
Analysis of the Effect of Service Quality on Customer Loyalty with Customer Satisfaction as a Mediator at Kos X in Sidoarjo
Authors: Permatasari Aini Intan 
Published: July 2023

This study aims to test the effect of service quality on customer loyalty with the variable of customer satisfaction mediation at boarding house X in Sidoarjo. This study uses quantitative methods using SmartPLS for data processing. The number of respondents in this study was 122 boarding house tenants selected using the purposive sampling method. The results showed that service quality affects customer satisfaction, service quality affects customer loyalty, customer satisfaction affects customer loyalty, and customer satisfaction has an effect on mediating service quality on customer loyalty.