bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Single Intravenous Injection of Esketamine on Postpartum Depression after Labor Analgesia and Potential Mechanisms: A Randomized, Double-blinded Controlled Trial
Authors: Ling Bin , Zhu Yun , Yan Zelin , Chen Hao , Xu Hua , Wang Qi , Yu Wanyou , Wang Wei 
Published: June 2023

Abstract
Background：The study was designed to investigate effects of single intravenous injection of esketamine on the incidence of postpartum depression (PPD) after labor analgesia and explore the potential mechanisms.
Methods：A total of 120 women who underwent labor analgesia by epidural analgesia pump were enrolled and divided into two groups randomly. Esketamine at a dose of 0.2 mg/kg was intravenously injected after fetal disengagement in the test group and placebo was administered in the control group. The occurrence of PPD and side effects after delivery were recorded. Some indicators related to stress and inflammation were measured before labor analgesia and at 24 hours, 1 week, and 6 weeks after delivery in this study. Data were analyzed by independent t-test, repeated measures analysis of variance and Chi-square test in SPSS software (version 25.0). It was considered statistically significant since a p value less than 0.05.
Results：The incidence of PPD was significantly decreased both for one week and six weeks after delivery by using of esketamine (3.4% vs 15.3%, p = 0.004 and 5.2% vs 18.6%, p = 0.006, respectively) . There were also significant differences between the stress and inflammation-related indicators in different time points in this study, while the side effects for 48 hours after delivery were similar between the two groups.
Conclusions：Single intravenous injection of esketamine after delivery in participants underwent labor analgesia can decrease the occurrence of postpartum depression for one week and six weeks after delivery, while the side effects were not increased. The antidepressant effects of esketamine may be related to the reduction of stress response and inflammation.
KLF7 promotes neuroblastoma differentiation through regulation neuroblast differentiation-associated protein AHNAKs and is a marker of clinical outcome
Authors: Qiao Shupei , Jia Ying , Xie Li , Jing Wenwen , Xia Yang , Song Yue , Zhang Jiahui , Cao Tianhua , Song Huilin , Meng Lingdi , Shi Lei , Zhang Xue 
Published: June 2023

Abstract
Background Recent studies have revealed that neuroblastomas share a close transcriptional similarity with developing adrenal neuroblasts which were often overlooked in previous studies andconfirmed that the neuroblast identity of the neuroblastoma cells. Accumulated data suggest that a differentiation arrest in sympathoadrenal neuroblasts contributes to the formation of neuroblastoma. It has been proposed that KLF7 is a neuroblastoma super-enhancer-associated transcription factor gene. Moreover, KLF7 strongly active in postmitotic neuroblasts of the developing nervous system during embryogenesis. However, the role of KLF7 in the differentiation of neuroblast or neuroblastoma is unknown.
Methods Human neuroblastoma cells were used to assess the effects of KLF7 on the proliferation and differentiation biological behaviors of neuroblastoma. CHIP-seq and RNA-seq were used to detect the target gene of KLF7 in neuroblastoma. Luciferase assay, GTPase activity assayand Immunoblotting were utilized to determine the protein–promoter interactions and related molecular mechanisms.
Results Firstly, we find a strong association between high KLF7 expression and favorable clinical outcomes in neuroblastoma. Moreover, we find that KLF7 not only inhibits proliferation but also induces differentiation of neuroblastoma cells, surpassing the effects of previously reported neuroblastoma differentiation genes. Furthermore, we are the first one to report that KLF7 binds directly to the promoters of neuroblast differentiation-associated protein (AHNAK and AHNAK2) and regulates their expression to influence the MAPK pathway and GTPase activity and then induces differentiation of neuroblastoma which also indicates that KLF7 plays a crucial role in neuroblast differentiation through regulating neuroblast differentiation-associated protein AHNAKs expression. As reported that KLF7 was a neuroblastoma super-enhancer-associated transcription factor gene, we also observe that depletion of KLF7 in neuroblastoma cells promotes the adrenergic-to-mesenchymal transition, accompanies by changes in enhancer-mediated gene expression.
Conclusion we are the first one to report that KLF7 binds directly to the promoters of neuroblast differentiation-associated protein (AHNAK and AHNAK2) and regulates their expression to influence the GTPase activity and then induces differentiation of neuroblastoma which also indicates that KLF7 plays a crucial role in neuroblast differentiation. Our results reveal KLF7 as an inducer of neuroblast or neuroblastoma differentiation with prognostic significance and potential therapeutic value.
Plasma driven ammonia synthesis over silica: The role of the catalyst morphology and porous structure
Authors: Nguyen Hoang M. , Gorky Fnu , Jasinski Jacek B. , Carreon Maria L. 
Published: June 2023

Abstract
Non-thermal plasma (NTP) has opened novel routes for ammonia production, providing a powerful and high-performance rivalling the conventional Haber-Bosch process. Yet, the enhancement of ammonia yield over NTP driven catalytic processes is still challenging. In this work, ammonia synthesis performance is tailored by the morphology and textural properties including surface area and pore size volume of various silica catalysts. Experimental results indicated the effects of different catalyst surface areas, pore sizes, and morphology on the surface discharge. Spherical macroporous silica displays the highest ammonia production rate of 0.14 mmol min-1 m-2 at a power of 15W. The spherical macroporous silica offers a more uniform discharge, enhancing the reaction of unreacted N2 and H2 and allowing their diffusion and absorption inside the pores to form ammonia. The findings from this work provide insights for tailoring catalyst porous structure and morphology for ammonia production powered by non-thermal plasma.
Viability of Lactobacillus acidophilus La-14 included in spray-dried microdiets for fish larvae
Authors: Martínez-Ángeles Eduardo , Ríos-Durán María Gisela , Navarrete-Ramírez Pamela , Raggi Luciana , Martínez-Chávez C. Cristian , Martínez-Palacios Carlos A. 
Published: June 2023

Abstract
Despite that, probiotics in fish feeds have shown positive growth and survival results in several freshwater and marine fish species; maintaining probiotic viability in dry feed has been a challenge, especially regarding spray-dried microdiets, although it is assumed that the nature of the process has the potential to encapsulate and protect probiotics with minimal chemical modification. Nevertheless, scarce information exists about the influence of the process and microdiet handling conditions. Therefore, this study evaluated the effect of the spray-drying process, storage time, and marine water exposure on the viability of L. acidophilus encapsulated in microdiets. The results suggest that spray-dried microdiets, including L. acidophilus La-14, can be stored for up to 6 months at 4 ºC maintaining an adequate CFU count (> 109) and can be used as a probiotic supplement in microdiets for marine and freshwater fish larvae. This raises the possibility of implementing new feeding strategies, such as using enriched microdiets with probiotic strains capable of resisting salinity and long-term storage, which can have an essential application for the aquafeed industry.
Safety of JAK and IL-6 inhibitors in rheumatoid arthritis: a multicentor cohort study
Authors: Yoshida Shuhei , Miyata Masayuki , Suzuki Eiji , Kanno Takashi , Sumichika Yuya , Saito Kenji , Matsumoto Haruki , Temmoku Jumpei , Fujita Yuya , Matsuoka Naoki , Asano Tomoyuki , Sato Shuzo , Migita Kiyoshi 
Published: June 2023

Abstract
Objective
The ORAL surveillance showed a potentially higher incidence of malignancy and major adverse cardiovascular events (MACEs) with tofacitinib compared to tumor necrosis factor (TNF) inhibitors (TNFi), but little is known about safety comparisons in non-TNFi or other Janus kinase inhibitors (JAKi). This study aimed to compare the incidence (IR) of malignancies and major adverse cardiovascular events in rheumatoid arthritis (RA) patients treated with interleukin-6 inhibitor (IL-6i) or JAKi.
Methods
We retrospectively analyzed the cases of 427 RA patients treated with IL-6i (n = 273), or a JAKi (n = 154). We determined the IRs of malignancy and MACEs, and the standardized incidence ratio (SIR) of malignancies and investigated the factors related to malignancy and MACEs. After adjusting the clinical characteristic imbalance by propensity score matching (PSM), we compared the incidence of adverse events between the JAKi and IL-6i groups.
Results
Observational period after propensity score matching (PSM): 605.27 patient-years (PY); median observational period: 2.28 years. We identified 12 cases of malignancy (IR: 3.70 per 100 PY) in JAKi-treated group and 10 cases (IR: 1.06 per 100 PY) in IL-6i-treated group after PSM. The IR of MACEs were 3.08 and 0.43 (per 100 PY) in JAKi and IL-6i-treated group. The IRRs of JAKi-treated patients versus IL-6i-treated patients were 2.13 (95%CI: 0.67–7.42) for malignancy and 3.03 (95%CI: 0.77–15.21) for MACE. There were no significant differences in IRR for malignancy and MACE between JAKi treatment and IL-6i treatment after PSM. Univariate or Multivariable Cox regression analyses revealed independent risk factors: older age, JAKi use in malignancy and older age, hypertension, JAKi use in MACEs. The overall malignancy SIR was significantly higher in the JAKi treatment group compared to the general population (2.10/100PY, 95%CI: 1.23–2.97).
Conclusions
The malignancy and MACEs IR in RA after PSM was comparable between IL-6i and JAKi. However, the SIR of malignancy in JAKi treatment was significantly higher than in the general population, therefore, further safety studies comparing JAKi to non-TNFi bDMARDs are needed.
Global invasion reconstructed and spatio-temporal distribution pattern dynamics of Sorghum halepense under climate and land-use change
Authors: Yang Ming , Zhao Haoxiang , Xian Xiaoqing , Qi Yuhan , Li Qiao , Guo Jianying , Chen Li , Liu Wanxue 
Published: June 2023

Abstract
Context
Sorghum halepense competes with crops and grass species in cropland, grassland, and urban, increasing invasion risk. However, invasive historical dynamics and distribution patterns of S. halepense associated with current and future climate change and land-use change (LUC) remain unknown.
Objectives
We first analyzed invasive historical dynamics of S. halepense to explore its invasion status and expansion trends. We then used species distribution model to examine whether future climate change and LUC will facilitate the invasion of S. halepense.
Methods
We reconstructed invasive historical countries of S. halepense based on databases with detailed recorded countries and occurrences. We run biomod2 based on climate data and land-use data at 5’ resolution, assessing the significance of environmental variables and LUC.
Results
Sorghum halepense was widely distributed worldwide through grain trade and forage introduction, except in Africa. Future global cropland and urban areas were expected to increase, yet grassland areas decreased. Europe and North America provided more the PGSH of S. halepense in cropland, grassland, and urban, covering 48.69%, 20.79%, and 84.82%, respectively. The future PGSH of S. halepense increased continuously in Northern Hemisphere, transferring to higher latitudes. Environmental variables were more significant than LUC in predicting the PGSH of S. halepense.
Conclusions
We constructed species distribution models associated with the near current and future environmental variables and LUC. Future PGSH of S. halepense was expected to increase, increasing invasion risk on agricultural LUC. These results are basic for the early warning and prevention of S. halepense worldwide.
Association between dust exposure and dyslipidemia among coal miners: a population-based cross-sectional study
Authors: Zhao Hui , Tao HuiHui , Fu Jifeng , Hou Weilong , Hu Chunxiao , Liu Yafeng , Ding Xuansheng , Hu Dong 
Published: June 2023

Abstract
Objective
The aim of this study was to investigate the relationship between dust exposure and dyslipidemia among coal miners, and to identify related risk factors.
Methods
A cross-sectional study was conducted on 5433 coal miners who underwent occupational health examinations at the Huainan Yangguang Xinkang Hospital. Participants were divided into two groups based on the presence or absence of dyslipidemia, and their baseline information and dust exposure status were recorded. Univariate analysis was used to screen for risk factors associated with dyslipidemia, and multivariate logistic regression analysis was performed to adjust for potential confounding factors. Stratified analyses and smooth curve fitting were used to explore the effect of dust exposure on dyslipidemia in different subgroups. A silica-exposed mouse model was established to confirm the causal relationship between dust exposure and dyslipidemia.
Results
Of the 5433 coal miners included in the study, 3162 (58.2%) had dyslipidemia. Univariate analysis indicated that dust exposure, sex, age, body mass index (BMI), and abnormal blood pressure were significant risk factors for dyslipidemia (P-value < 0.001). Multivariate logistic regression analysis adjusted for confounding factors showed that dust exposure was still significantly associated with dyslipidemia. Stratified analyses and smooth curve fitting further confirmed the effect of dust exposure on dyslipidemia in different subgroups. The silica-exposed mouse model confirmed the causal relationship between dust exposure and dyslipidemia.
Conclusion
These findings highlight the potential impact of dust exposure on cardiovascular health in coal miners, and emphasize the need for prevention and control measures. Dust exposure was identified as an important risk factor for dyslipidemia among coal miners, which should be taken seriously and addressed effectively.
Validation of a Latin American Spanish version of the Body Esteem Scale for Adolescents and Adults (BESAA-LA) in Colombian and Nicaraguan adults
Authors: Andres Fabienne E. , Thornborrow Tracey , Bowie Wienis N. , Coneo Ana Maria Chamorro , Rosa Gisell de la , Evans Elizabeth H. , Acuña Laura S. Fontalvo , Kolar David R. , Chams Moises R. Mebarak , Castro Juan Camilo Tovar , Boothroyd Lynda G. 
Published: June 2023

Abstract
Background
Body dissatisfaction (BD) is a growing concern in Latin America; reliable and culturally appropriate scales are vital to promote body image research in Spanish speaking Latin American countries. We validated a Latin American Spanish version of the Body Esteem Scale for Adolescents and Adults (BESAA; Mendelson et al., 2001).
Methods
The scale was translated, culturally adapted, and validated with adults in Colombia (N = 525, 65% women, Mage 24.4, SD = 9.28). We assessed factor structure (using confirmatory and exploratory factor analysis CFA and EFA), internal reliability (using Cronbach’s alpha and omega), validity (using the Body Appreciation Scale BAS and Sociocultural Attitudes Towards Appearance Questionnaire SATAQ), test-retest stability (using Intraclass correlations ICC) and measurement invariance. To evaluate the generalizability of the scale, we assessed reliability, validity, and factor structure in a second sample from rural Nicaragua (N = 102, 73% women, Mage 22.2, SD = 4.72).
Results
The scale showed excellent internal reliability and validity across both samples. Test-retest stability and invariance across gender was established for the Colombian sample. EFA showed a three-factor structure with the subscales appearance-positive, appearance-negative and weight that was confirmed using CFA in both the Colombian and Nicaraguan sample and showed invariance across countries.
Conclusion
The Latin American Spanish version BESAA-LA is a psychometrically sound measure with excellent reliability, validity and invariance across gender and countries. Therefore, we recommend its use in diverse Latin American adult populations to measure body satisfaction/dissatisfaction.
From active treatment to surveillance: How the barriers and facilitators of implementing survivorship care planning could be an opportunity for telehealth in oncology care for rural patients.
Authors: Alford-Teaster Jenn , Vaclavik Danielle Danielle , Imset Inger , Schiffelbein Jenna , Lyons Kathleen , Kapadia Nirav , Olson Ardis , McGrath Elizabeth , Schifferdecker Karen , Onega Tracy 
Published: June 2023

Abstract
Purpose: Cancer survivorship care planning is a recognized yet underutilized aspect of care delivery and the opportunity for telehealth in cancer survivorship is examined.
Methods:
We conducted a mixed-methods study in Vermont and New Hampshire to characterize perceptions of rural cancer providers and survivors regarding survivorship transitions in care, consisting of: a) key informant interviews with primary care and oncology clinicians, b) a broader survey of clinicians, and c) surveys and focus group discussions with cancer survivors. In these interactions, we also explored the use of a shared telehealth survivorship care planning appointment between oncology clinicians, primary care clinicians, and survivors

Results:
Results from surveys and interviews clustered around several themes, namely: 1) infrequent care transitioning back to primary care; 2) lack of mental health services; 3) lack of side effect education; 4) low perceived utility of survivorship care plans; 5) clinicians exclusively communicate using the EMR and finding it imperfect; and 6) clinicians and survivors reported conflicting perceptions regarding survivors’ access to telehealth options.
Conclusions:
Our results suggest that telehealth has potential to augment the delivery of survivorship care planning; however, key technical and logistical concerns need to be addressed, particularly enhanced coordination across clinician scheduling and ensuring payment parity for various telehealth implementation strategies.
Implications for Cancer Survivors:
Cancer survivorship care planning is a recognized yet underutilized aspect of care delivery. There is an opportunity for the application of telehealth for supportive care in survivorship care planning, which should be a focus of further research.
Reinforcement Learning with Decoupled State Representation for Robot Manipulations
Authors: Dong Kun , Luo Yongle , Wang Yuxin , Cheng Erkang , Sun Zhiyong , Zhang Qiang , Bo Song 
Published: June 2023

Abstract

Deep reinforcement learning (DRL) has advanced robot manipulations with an alternative solution to design a control strategy using the raw image as the input directly. Although the image usually comes up with more knowledge about the environment, it needs the policy to achieve representation learning and task learning simultaneously, which is a sample inefficient task. Previous attempts, such as Variational Autoencoder (VAE) based DRL algorithms have attempted to solve this problem by learning a visual representation model, which encodes the entire image into a low-dimension vector. However, since the vector contains both the robot and object information, the coupling within the state is inevitable, which could mislead the training process of DRL policy. In this study, a novel method named Reinforcement Learning with Decoupled State Representation (RLDS) is proposed to decouple the robot and object information to increase the learning efficiency and effectiveness. The experimental results have shown that the proposed method has a faster learning speed and can achieve better performance compared with previous methods in several typical robot tasks. Additionally, with only 3,096 offline images, the proposed method can be successfully applied to a real robot pushing task, which demonstrates its high practicability.
Real-World Outcomes of Nivolumab, Pembrolizumab, and Atezolizumab Treatment Efficacy in Korean Veterans with Stage IV Non-Small-Cell Lung Cancer
Authors: Ham Ahrong , Lee Young , Kim Hae Su , Lim Taekyu 
Published: June 2023

Abstract
In clinical settings, patients receiving immune checkpoint inhibitors (ICIs) have different treatment criteria from those enrolled in clinical trials. There are concerns regarding the efficacy of ICIs in older adults due to the age-associated decline in the immune system, and no study has directly compared the efficacy of different ICIs in a real-world setting. We aimed to analyze ICIs use and treatment outcomes in Korean veterans with stage IV non-small-cell lung cancer (NSCLC). In total, 180 patients diagnosed with stage IV NSCLC between 2016 and 2021 were included in this analysis. Three cohort groups were derived based on ICI type (pembrolizumab, nivolumab, and atezolizumab treatment groups), and their clinical characteristics and survival outcomes were compared. The predictors of survival outcomes in patients with NSCLC were investigated using a Cox regression model. The objective response rate (ORR) was 22.4%, 8.2%, and 4.3% in the pembrolizumab, nivolumab, and atezolizumab groups, respectively, whereas the disease control rate (DCR) was 59.2, 55.7%, and 30.0%, respectively. There was no difference in the overall survival (OS) rate among the groups, and no treatment-specific OS benefit was observed relative to tumor PD-L1 expression, and bone metastasis was a poor prognostic factor for OS. Pembrolizumab and nivolumab were associated with a significant increase in ORR and DCR compared with atezolizumab, and there was no statistically significant difference in survival outcomes among the three ICIs, demonstrating that they may be an appropriate treatment option for older patients.
Chemotherapy Safe Handling Practices in Ethiopia: A Comprehensive Multi-Center Mixed-Method Evaluation
Authors: Webb Nathaniel , Matys Samantha , IV James B. Collins , Garcia Julian , Worku Kaleab , Lines Mandee , Hirata Hailey , Dark Erin , Brooks Callee , Buhlinger Kaitlyn , Fentie Atalay Mulu , Roberts Megan C. , Muluneh Benyam 
Published: June 2023

Abstract
The increasing incidence of cancer and capacity for cancer care in Ethiopia has led to an upsurge in chemotherapy use in the country; however, studies indicate that there is a gap in the safe handling of chemotherapy by healthcare workers. There exists a need to understand if such unsafe practices occur across the diverse Ethiopian health system and what specific areas along the chemotherapy life cycle need the most improvement. This study utilized a mixed-methods design through an online survey administered to health care professionals across Ethiopia and evaluative site visits of cancer units in Addis Ababa, Ethiopia to understand the current conditions of chemotherapy handling. 8 cancer units were evaluated and a total of 67 Ethiopian health care professionals responded to the survey. 55% (n = 21/38) of survey participants disagreed or strongly disagreed that there are systems in place to identify, prevent, and address chemotherapy hazards in their workplace, and 71% (n = 25/35) of respondents denied having an active and effective health and safety committee and/or worker health and safety representative where they work. At evaluative site visits, 30% (n = 26/88) of health care workers met the minimum guidelines for proper hand hygiene, and 20% (n = 8/40) of health care workers used adequate PPE according to guidelines across the chemotherapy lifecycle. Results of this study indicate an urgent need for implementation of evidence-based interventions to improve chemotherapy handling in Ethiopia so that all patients and health care workers are protected from the hazardous toxicities of these drugs.