bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole mitogenomes reveal that NW Africa has acted both as a source and a destination for multiple human movements
Authors: Aizpurua-Iraola Julen , Abdeli Amine , Benhassine Traki , Calafell Francesc , Comas David 
Published: June 2023

AbstractDespite being enclosed between the Mediterranean Sea and the Sahara Desert, North Africa has been the scenario of multiple human migrations that have shaped the genetic structure of its present-day populations. Despite its richness, North Africa remains underrepresented in genomic studies. To overcome this, we have sequenced and analyzed 264 mitogenomes from the Algerian Chaoui-speaking Imazighen (a.k.a. Berbers) living in the Aurès region. The maternal genetic composition of the Aurès is similar to Arab populations in the region, dominated by West Eurasian lineages with a moderate presence of M1/U6 North African and L sub-Saharan lineages. When focusing on the time and geographic origin of the North African specific clades within the non-autochthonous haplogroups, different geographical neighboring regions contributed to the North African maternal gene pool during time periods that could be attributed to previously suggested admixture events in the region, since Paleolithic times to recent historical movements such as the Arabization. We have also observed the role of North Africa as a source of geneflow mainly in Southern European regions since Neolithic times. Finally, the present work constitutes an effort to increase the representation of North African populations in genetic databases, which is key to understand their history.
Detection of incomplete atypical femoral fracture on anteroposterior radiographs via explainable artificial intelligence
Authors: Kim Taekyeong , Moon Nam Hoon , Goh Tae Sik , Jung Im Doo 
Published: June 2023

AbstractOne of the key aspects of the diagnosis and treatment of atypical femoral fractures is the early detection of incomplete fractures and the prevention of their progression to complete fractures. However, an incomplete atypical femoral fracture can be misdiagnosed as a normal lesion by both primary care physicians and orthopedic surgeons; expert consultation is needed for accurate diagnosis. To overcome this limitation, we developed a transfer learning-based ensemble model to detect and localize fractures. A total of 1050 radiographs, including 100 incomplete fractures, were preprocessed by applying a Sobel filter. Six models (EfficientNet B5, B6, B7, DenseNet 121, MobileNet V1, and V2) were selected for transfer learning. We then composed two ensemble models; the first was based on the three models having the highest accuracy, and the second was based on the five models having the highest accuracy. The area under the curve (AUC) of the case that used the three most accurate models was the highest at 0.998. This study demonstrates that an ensemble of transfer-learning-based models can accurately classify and detect fractures, even in an imbalanced dataset. This artificial intelligence (AI)-assisted diagnostic application could support decision-making and reduce the workload of clinicians with its high speed and accuracy.
The mechanism and performance of rock breakage by undercutting disc cutter with advanced slotting
Authors: Jiang Hongxiang , Zhang Xiaodi , Zhao Huihe , Liu Zenghui , Wang Yongxin 
Published: June 2023

AbstractTo study the mechanism and performance of rock breakage by an undercutting disc cutter with advanced slotting, a three-dimensional numerical model of rock cutting by a disc cutter with advanced slotting assistance was established based on the discrete element method. The parallel bond constitutive model was selected to describe the micromechanical properties of rock. The correctness of the established numerical model is verified through rock breakage experiments, and the rock cutting process by the disc cutter was analyzed by a combination of the force chain and crack distribution. The influencing factors, such as advanced slotting depth, cutting thickness, rock strength, and cutter rotation speed, on rock cutting performance were investigated. The results show that a compact zone is gradually formed between the rock and disc cutter at the beginning, then a large number of microscopic tensile and shear cracks in the compact zone due to micro failure of rock are formed; the subsequent main rock fragment is mainly caused by tensile failure; advanced slotting can reduce the rock bearing capacity and bending resistance, the rock above the advanced slotting fractured easily due to its lower bending resistance, and the volume compact zone is relatively small. When the advanced slotting depth is equal to 12.5 mm, the propulsive force and specific energy consumption of rock cutting by the disc cutter are reduced by 61.6% and 16.5%, respectively. The propulsive force and specific energy consumption increase as the rock strength increases, but they tend to close when the rock strength is greater than 80 MPa, which indicates that advanced slotting assistance is more suitable for hard rock. The results obtained in this paper can provide the operating parameters determination under different factors to some extent of the undercutting disc cutter in a pre-cut condition, which further improve the rock breaking performance of mechanized cutter.
Identification of candidate lethal haplotypes and genomic association with post-natal mortality and reproductive traits in Nellore cattle
Authors: Schmidt Patrícia Iana , Mota Lucio Flavio Macedo , Fonseca Larissa Fernanda Simielli , dos Santos Silva Danielly Beraldo , Frezarim Gabriela Bonfá , Arikawa Leonardo Machestropa , de Abreu Santos Daniel Jordan , Magalhães Ana Fabrícia Braga , Cole John Bruce , Carvalheiro Roberto , de Oliveira Henrique Nunes , Null Daniel Jacob , VanRaden Paul , Ma Li , de Albuquerque Lucia Galvão 
Published: June 2023

AbstractThe wide use of genomic information has enabled the identification of lethal recessive alleles that are the major genetic causes of reduced conception rates, longer calving intervals, or lower survival for live-born animals. This study was carried out to screen the Nellore cattle genome for lethal recessive haplotypes based on deviation from the expected population homozygosity, and to test SNP markers surrounding the lethal haplotypes region for association with heifer rebreeding (HR), post-natal mortality (PNM) and stayability (STAY). This approach requires genotypes only from apparently normal individuals and not from affected embryos. A total of 62,022 animals were genotyped and imputed to a high-density panel (777,962 SNP markers). Expected numbers of homozygous individuals were calculated, and the probabilities of observing 0 homozygotes was obtained. Deregressed genomic breeding values [(G)EBVs] were used in a GWAS to identify candidate genes and biological mechanisms affecting HR, STAY and PNM. In the functional analyses, genes within 100 kb down and upstream of each significant SNP marker, were researched. Thirty haplotypes had high expected frequency, while no homozygotes were observed. Most of the alleles present in these haplotypes had a negative mean effect for PNM, HR and STAY. The GWAS revealed significant SNP markers involved in different physiological mechanisms, leading to harmful effect on the three traits. The functional analysis revealed 26 genes enriched for 19 GO terms. Most of the GO terms found for biological processes, molecular functions and pathways were related to tissue development and the immune system. More phenotypes underlying these putative regions in this population could be the subject of future investigation. Tests to find putative lethal haplotype carriers could help breeders to eliminate them from the population or manage matings in order to avoid homozygous.
Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites
Authors: Ślosarczyk Agnieszka , Klapiszewska Izabela , Parus Anna , Balicki Sebastian , Kornaus Kamil , Gapiński Bartosz , Wieczorowski Michał , Wilk Kazimiera A. , Jesionowski Teofil , Klapiszewski Łukasz 
Published: June 2023

AbstractCuO nanoparticles (NPs) were added to cement matrices in quantities of 0.25, 0.50 and 1.00 wt% to inhibit the growth of Gram-positive (Bacillus cereus, Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, Escherichia coli) bacteria. It was shown that CuO NPs, in all tested concentrations, improved the antibacterial properties of the cement matrix. Nevertheless, the best mechanical, structural and durability properties were obtained for cement composites doped with CuO NPs at 0.25 wt%. Larger amounts of NPs caused a decrease in all parameters relative to the reference mortar, which may be the result of a slight change in the porosity of the composite microstructure. For 0.50 wt% CuO NPs, a slight increase in the volume of micropores in the cement matrix was observed, and an increased number of larger pores was confirmed by non-invasive computed tomography (CT). The reduction in the mechanical parameters of composites with 0.50 and 1.00 wt% CuO NPs may also be due to the slower hydration of the cement binder, as confirmed by changes in the heat of hydration for these configurations, or agglomeration of NPs, especially for the 1.00 wt% concentration, which was manifested in a decrease in the plasticity of the mortars.
Normal umbilical artery doppler values in 18–22 week old fetuses with single umbilical artery
Authors: Kazci Omer , Aydin Sonay , Fatihoglu Erdem , Tokur Oğuzhan , Bahadir Suzan , Karavas Erdal , Kantarci Mecit 
Published: June 2023

AbstractUmbilical cord with a single umbilical artery (SUA) can carry twice the blood volume of a three-vessel cord (TVC). So, the normal hemodynamics of the fetuses with SUA was different from those with TVC. Furthermore, structural abnormalities, fetal aneuploidy, and intrinsic growth retardation may be associated with the presence of a SUA. In order to evaluate these patients, intermittent doppler measurements have been suggested. From this point, we aimed to determine the CDUS flow parameters in SUA cases and to demonstrate that these flow parameters are different from the TVC parameters. Ultrasound (US) examinations were performed in the 18–22 weeks of gestation during routine fetal anatomy screening. Resistance index (RI), Pulsatility index (PI), and S/D: systole to diastole ratio values were measured. The samples were taken from the proximal, mid-portion, and distal of the umbilical cord. In addition to Doppler Ultrasound values, AC and estimated fetal weight (EFW) values were also recorded. The study included 167 pregnant women, 86 of whom were study group with SUA and 81 were control group with TVC. The measurements of RI, PI, and S/D at all three levels were significantly lower in the SUA group compared to the TVC group. The resistance in the UA of fetuses with SUA is lower than in fetuses with TVC. The resistance in the UA of fetuses with SUA decreases from the fetal end to the placental end. Knowing the normal values for fetuses with SUA might provide a better and more reliable Doppler Ultrasoundassessment.
End‐winding wire‐insulation heat conduction model for precise thermal predictions of permanent magnet synchronous machines
Authors: Li Longnv , Liu Shijie , Shang Yatao , Xue Ming , Liu Tao , Zhu Gaojia 
Published: June 2023

AbstractAccurate thermal calculations of end‐winding temperature rises are the key issue in designing and developing cooling systems of permanent magnet synchronous machines (PMSMs). Due to the complex connections of the end‐windings, it is challenging to precisely predict the heat dissipation capacities through a traditional wire‐insulation equivalent model. Numerical simulations and lumped parameter thermal networks (LPTN) are used by the authors to develop thermal models that illustrate the end‐winding properties of a 2.1‐kW PMSM. As multi‐strand end wires are bent and bound together by ribbons, they have thermal interrelations which can hardly be considered in LPTN models. An equivalent coefficient enhancing the axial heat conduction capacities of end‐windings is proposed for LPTN calculations to model the aforementioned thermal interrelations with circumferential symmetric structures. To correctly model the mutual thermal coupling between various strands of end‐windings, the thermal conductivity of the equivalent insulation sheets between the multi‐strand end‐windings is determined for exact numerical calculations. The external insulation sheet thickness is calculated based on the equivalent thermal conductivity. After developing heat conduction models for LPTN and numerical simulations, LPTN and FEA are used to determine the PMSM's temperature rise characteristics. To verify the approaches, the computation findings are contrasted with experimental ones.
Park‐and‐ride choice behaviour under multimodal travel information—Analysis based on panel mixed logit model
Authors: Huang Yue , Gan Hongcheng , Lu Huan , Wang Xinyu , Wang Wenjing 
Published: June 2023

AbstractUnderstanding the impact of smartphone‐based multimodal information (SMMI) on travellers' P&R (park‐and‐ride) choice behaviour is very limited so far. The purpose of this study is to better understand how SMMI, social network information, and individual characteristics influence travellers' mode choices. A stated preference experiment consisting of one P&R option and two auto‐driving routes was conducted to collect car commuters’ P&R choice data in Shanghai, China. The panel mixed logit model was utilized to determine the influencing factors. It was found that the panel mixed logit model, accounting for correlations among repeated observations of the same respondent and random taste, significantly outperforms the cross‐sectional multinomial logit model in terms of goodness‐of‐fit. Specifically, travellers are highly sensitive to the information offered by SMMI on travel time, parking fare, and crowding level in subway cars, and heterogeneities do exist in travellers' preferences for these factors. In terms of social network information, the positive propensity of online reviews and information about P&R play a positive role in P&R promotion. In addition, individual characteristics including gender, age, occupation, years of driving, and P&R experience all contribute to explaining the choice of P&R. Finally, the elasticity analysis reveals that commuters are more satisfied with P&R time than with car time, and the cross elasticity of P&R time demonstrates a limited substitution effect of P&R on private cars.
Dual‐band filtering power amplifier with extended passband bandwidths and wide stopband rejection
Authors: Dong Gaoya , Yang Xiaolong , Fang Yunnan , Tenzeris Manos M. 
Published: June 2023

AbstractThis article presents a dual‐band filtering power amplifier (DB‐FPA) with extended passband bandwidths and wide stopband rejection, which is helpful in reducing the number of microwave components in the dual‐band radio frequency front end, resulting in compact circuit size and low loss. In the designed DB‐FPA, a wideband low‐pass filter is applied as the input matching network (IMN) to provide wideband impedance matching and good stopband rejection, while a dual‐band filtering impedance transformation is adopted as the output matching network (OMN) to provide dual‐band impedance matchings and filtering responses simultaneously. Specifically, the IMN is constructed by high‐impedance transmission‐line sections and low‐impedance open‐circuit stubs. The OMN is designed based on the specific external quality factors and coupling coefficients during two bands, resulting in dual‐band impedance transformations and dual‐band filtering responses. Then, based on the above IMN and OMN, the design procedure of the presented DB‐FPA is summarised. To verify the proposed idea, a novel DB‐FPA has been fabricated and measured. During the two frequency bands, the measured maximum power added efficiencies are 55.11% and 47.78% within 33.0 dBm input power, while the measured peak gains are 15.4 and 14.0 dB within 15.0 dBm input power.
Research progress of intrinsic polymer dielectrics with high permittivity
Authors: Chen Kaijin , Liu Zunchu , Zheng Weiwen , Liu Siwei , Chi Zhenguo , Xu Jiarui , Zhang Yi 
Published: June 2023

AbstractThe high permittivity of polymer dielectrics facilitates their use in the electronics industry. Compared to inorganic ceramics and composites, intrinsic high permittivity polymer dielectrics have the advantages of easy solution processing and better homogeneity. The permittivity of common polymers is generally low, hence it would be worthwhile to explore avenues for augmenting the permittivity of polymer dielectrics via judicious and efficient structural design. The effective strategies used to increase the permittivity of intrinsic polymers encompass elevating local polarisabilities by fortifying electron delocalisation capabilities, exploiting ion pairs to generate atomic clusters with larger dipole moments, amplifying dipole density, augmenting dipole mobility, and so forth. Due to the rigidity and flexibility of the polymer backbone's decisive influence on the dielectric's all‐around performance, its selection also requires a total consideration of the requirements of practical applications. This work provides an overview and a brief evaluation of the dominant design strategies and mentions possible future design paradigms for polymer dielectrics.
Optimal resource optimisation based on multi‐layer monitoring
Authors: Uzunidis Dimitrios , Karkazis Panagiotis , Leligou Helen C. 
Published: June 2023

AbstractThe satisfaction of the Quality of Service (QoS) levels during an entire service life‐cycle is one of the key targets for Service Providers (SP). To achieve this in an optimal way, it is required to predict the exact amount of the needed physical and virtual resources, for example, CPU and memory usage, for any possible combination of parameters that affect the system workload, such as number of users, duration of each request, etc. To solve this problem, the authors introduce a novel architecture and its open‐source implementation that a) monitors and collects data from heterogeneous resources, b) uses them to train machine learning models and c) tailors them to each particular service type. The candidate solution is validated in two real‐life services showing very good accuracy in predicting the required resources for a large number of operational configurations where a data augmentation method is also applied to further decrease the estimation error up to 32%.
Smoking Status Trends between Primary Total Hip Arthroplasty Patients and the General Population from 2012 to 2021
Authors: Nwakoby Ekenedilichukwu , Bieganowski Thomas , Singh Vivek , Anil Utkarsh , Schwarzkopf Ran , Lajam Claudette M. 
Published: June 2023

AbstractSmoking is associated with an increased risk of complications, higher opioid use, and mortality following primary elective total hip arthroplasty (THA). Interventions for smoking cessation have been enhanced since value-based care was initiated in 2013. It remains unclear whether surgical optimization has influenced the proportion of smokers undergoing THA over time. Our study examines trends in the yearly proportions of smokers for primary elective THA versus patients having annual physical examinations (APEs). We retrospectively reviewed all patients of 18 years of age or older who underwent primary elective THA and those who had an APE at our institution between January 2012 and December 2021. The electronic medical record was queried for baseline demographics and documented smoking status. Linear regression analysis was used to determine trend significance. In total, 12,524 primary THA patients were matched in a 1:5 ratio to 62,630 APE patients using nearest-neighbor matching. Our analysis demonstrated significantly higher proportions of documented current and former smokers within the THA group at each time point compared with the APE group. The rate of current smokers undergoing THA demonstrated a downward trend that was not significant. There was a significant upward trend in documented current smokers presenting for an APE. Although there has been a decrease in active smokers undergoing THA at our institution over the past decade, this trend is not significant. Therefore, it remains unclear whether smoking cessation interventions have influenced patients undergoing primary THA. Continued vigilance in smoking cessation strategies is warranted, and improved documentation of smoking status may enhance our current understanding of whether optimization efforts are successful.
Level III Evidence Retrospective cohort study.
Pulmonary Physiology and Medicine of Diving
Authors: Tetzlaff Kay 
Published: June 2023

AbstractPulmonary physiology is significantly altered during underwater exposure, as immersion of the body and increased ambient pressure elicit profound effects on both the cardiovascular and respiratory systems. Thoracic blood pooling, increased breathing gas pressures, and variations in gas volumes alongside ambient pressure changes put the heart and lungs under stress. Normal physiologic function and fitness of the cardiovascular and respiratory systems are prerequisites to safely cope with the challenges of the underwater environment when freediving, or diving with underwater breathing apparatus. Few physicians are trained to understand the physiology and medicine of diving and how to recognize or manage diving injuries. This article provides an overview of the physiologic challenges to the respiratory system during diving, with or without breathing apparatus, and outlines possible health risks and hazards unique to the underwater environment. The underlying pathologic mechanisms of dive-related injuries are reviewed, with an emphasis on pulmonary physiology and pathophysiology.
Pulmonary Vein Varix: A Diagnostic Enigma
Authors: Howdekar Madhuri , Susarla Rammurti , Mutnuru Phani Chakravarty , GK Paramjyothi , Kalva Sanjeeva Prasad 
Published: June 2023

AbstractWe report a case of a 34-year-old woman who presented with chest pain, shortness of breath, and dry cough of 1 month duration. Contrast-enhanced computed tomography of the chest revealed an enlarged and tortuous right pulmonary vein that could not conclusively exclude a pulmonary arteriovenous malformation. Further evaluation with digital subtraction angiography excluded an arteriovenous malformation and confirmed the presence of a pulmonary vein varix. Accordingly, the patient was managed conservatively. This report highlights the need for catheter angiography in the diagnosis of pulmonary vein varix and provides a brief review of literature on the entity.
Vacuum deposited organic solar cells with BTIC-H as A–D–A non-fullerene acceptor
Authors: Habib Irfan , Kaienburg Pascal , Xia Dondong , Gough Olivia , Zhu Ming , Spruce Joseph , Li Weiwei , Riede Moritz 
Published: June 2023

The record power conversion efficiency of solution-processed organic solar cells (OSCs) has almost doubled since non-fullerene acceptors (NFAs) replaced fullerene derivatives as the best-performing acceptor molecules. The successful transition from C60 to NFAs is still pending for vacuum-thermal evaporated (VTE) OSCs, not least because most NFAs are too large to be evaporated without breaking. Due to VTE’s relevance in terms of industrial manufacturing, discovering high-performing VTE NFAs is a major opportunity for OSCs. Here, we fabricate evaporated OSCs based on the NFA BTIC-H known from solution processing. This A–D–A molecule has an unfused bithiophene core, 1,1-dicyanomethylene-3-indanone end groups, and hexyl side chains, making it small enough to be evaporated well. We pair BTIC-H with four commonly used evaporated donors—DCV5T-Me(3,3), DTDCPB, HB194, and SubNc—in planar heterojunctions. We observe appreciable photocurrents and a voltage loss of ∼0.8 V, matching that of corresponding C60 devices. Donor:BTIC-H bulk heterojunctions likely face charge collection issues due to unfavorable microstructure. Our work demonstrates one of few NFA based evaporated OSCs with encouraging performance results and gives one potential starting point for molecule design of further NFAs suitable for VTE.