bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiproliferative and apoptotic effects of telmisartan in human glioma cells
Authors: Chang Yung-Lung , Chou Chung-Hsing , Li Yao-Feng , Huang Li-Chun , Kao Ying , Hueng Dueng-Yuan , Tsai Chia-Kuang 
Published: June 2023

AbstractGlioblastoma is the most common primary central nervous system tumor in adults. Angiotensin II receptor blockers (ARBs) are broadly applied to treat hypertension. Moreover, research has revealed that ARBs have the capacity to suppress the growth of several cancer types. In this study, we assessed the effects of three ARBs with the ability to cross the blood brain barrier (telmisartan, valsartan and fimasartan) on cell proliferation in three glioblastoma multiforme (GBM) cell lines. Telmisartan markedly suppressed the proliferation, migration, and invasion of these three GBM cell lines. Microarray data analysis revealed that telmisartan regulates DNA replication, mismatch repair, and the cell cycle pathway in GBM cells. Furthermore, telmisartan induced G0/G1 phase arrest and apoptosis. The bioinformatic analysis and western blotting results provide evidence that SOX9 is a downstream target of telmisartan. Telmisartan also suppressed tumor growth in vivo in an orthotopic transplant mouse model. Therefore, telmisartan is a potential treatment for human GBM.
Deimplementation in the provision of opioid agonist treatment to achieve equity of care for people engaged in treatment: a qualitative study
Authors: Conway Anna , Marshall Alison D. , Crawford Sione , Hayllar Jeremy , Grebely Jason , Treloar Carla 
Published: June 2023

Abstract
Background
Deimplementation, the removal or reduction of potentially hazardous approaches to care, is key to progressing social equity in health. While the benefits of opioid agonist treatment (OAT) are well-evidenced, wide variability in the provision of treatment attenuates positive outcomes. During the COVID-19 pandemic, OAT services deimplemented aspects of provision which had long been central to treatment in Australia; supervised dosing, urine drug screening, and frequent in-person attendance for review. This analysis explored how providers considered social inequity in health of patients in the deimplementation of restrictive OAT provision during the COVID-19 pandemic.

Methods
Between August and December 2020, semi-structured interviews were conducted with 29 OAT providers in Australia. Codes relating to the social determinants of client retention in OAT were clustered according to how providers considered deimplementation in relation to social inequities. Normalisation Process Theory was then used to analyse the clusters in relation to how providers understood their work during the COVID-19 pandemic as responding to systemic issues that condition OAT access.

Results
We explored four overarching themes based on constructs from Normalisation Process Theory: adaptive execution, cognitive participation, normative restructuring, and sustainment. Accounts of adaptive execution demonstrated tensions between providers’ conceptions of equity and patient autonomy. Cognitive participation and normative restructuring were integral to the workability of rapid and drastic changes within the OAT services. Key transformative actors included communities of practice and “thought leaders” who had long supported deimplementation for more humane care. At this early stage of the pandemic, providers had already begun to consider how this period could inform sustainment of deimplementation. When considering a future, post-pandemic period, several providers expressed discomfort at operating with “evidence-enough” and called for narrowly defined types of data on adverse events (e.g. overdose) and expert consensus on takeaway doses.

Conclusions
The possibilities for achieving social equity in health are limited by the divergent treatment goals of providers and people receiving OAT. Sustained and equitable deimplementation of obtrusive aspects of OAT provision require co-created treatment goals, patient-centred monitoring and evaluation, and access to a supportive community of practice for providers.
Time of insemination in relation to pregnancy rates in beef cattle after oestrus detection with automated activity monitoring system
Authors: Haadem Caroline Sorknes , Holmøy Ingrid Hunter , Nødtvedt Ane , Martin Adam Dunstan 
Published: June 2023

Abstract
Background
The timing of artificial insemination is critical to achieve acceptable results in cattle production systems. Over the past 60 years the length and expression of oestrus in dairy cattle has altered. Recent studies have indicated the optimal timing for insemination after the commencement of oestrus may now be earlier than traditional recommendations in beef cattle, as is the case in dairy cattle. The aim of the current study was to evaluate the effect of time from onset of oestrus [as determined by an automated activity monitoring system (AAMS)] to artificial insemination (AI) on pregnancy outcome in Norwegian beef cattle. Five commercial beef suckler herds participated in a cohort study by providing data on the time of AAMS alarm and time of AI. Blood sampling on the day of AI was performed and serum progesterone concentration measured. Pregnancy detection was performed by transrectal ultrasonography and aging of the fetus performed when necessary. A mixed logistic regression model was fitted to study the effect of time from AAMS alarm to AI on pregnancy outcome. Time categories used in the model were < 12 h, 12–24 h, and > 24 h.

Results
AI periods (n = 229) with serum progesterone concentration < 1 ng/mL were available for analysis. Overall pregnancy risk per AI for the whole study period was 65.5%, with an inter-herd variation from 10 to 91%. Median time elapsed from AAMS alarm to AI was 17.75 h. Herd affected pregnancy outcome (P = 0.001), while breed and parity status (heifer/cow) did not. The time category closer to AAMS alarm 0–12 h showed a numerically lower pregnancy risk as compared to the baseline group which had AI 12–24 h after onset of oestrus.

Conclusion
This study found no evidence to support a change in the recommended timing of AI in beef suckler cows.
Development of the consensus‐based recommendations for Podiatry care of Neuropathy In Cancer Survivors (PodNICS): a Delphi consensus study of Australian podiatrists
Authors: Dars Sindhrani , Buckley Elizabeth , Beckmann Kerri , Roder David , Banwell Helen 
Published: June 2023

AbstractBackgroundChemotherapy Induced Peripheral Neuropathy (CIPN) is the most common presenting side effect of chemotherapy. As a sensory based neuropathy, this condition can persist for a long time after cessation of chemotherapy and impact the quality of life of cancer survivors. Podiatrists in Australia have been managing people with CIPN related lower limb complications, however guidelines on management of CIPN do not exist. The aim of this study was to achieve consensus and agreement of Australian podiatrists on strategies to best manage people presenting with symptoms of CIPN.MethodsAn online three‐round modified Delphi survey of Australian podiatrists with expertise in CIPN was conducted in line with recommendations for conducting and reporting of Delphi studies (CREDES). Panellists responded to open‐ended questions in Round 1, whereupon their responses were themed into statements and analysed for existing consensus. Statements not reaching consensus were returned during Round 2 to seek agreement from responders using a five‐point Likert scale and to allow responders to make further comments. For a statement to reach consensus or agreement, 70% or more of panellists needed to make the same comment or agree or strongly agree with the same themed statement. Statements reaching 50 to 69% consensus or agreement were returned to panellists in Round 3 for them to consider their responses in the light of group outcomes.ResultsRound one resulted in 229 comments from 21 of 26 podiatrists who agreed to participate. These comments were themed into 53 statements with 11 consensus statements accepted. Round 2 resulted in 22 statements reaching agreement, and 15 new statements being generated from 18 comments made by 17 respondents. Round 3 resulted in 11 statements reaching agreement. Outcomes were developed into a set of clinical recommendations for diagnosis and management of people presenting with CIPN. These recommendations provide guidance on 1) identifying common signs and symptoms of CIPN including sensory, motor and autonomic symptoms; 2) diagnosis and assessment of CIPN including neurological, motor and dermatological assessment modalities; and 3) best clinical practice and management strategies for CIPN identified by podiatrists including both podiatry and non‐podiatry specific care.ConclusionsThis is the first study in podiatry literature to develop expert‐informed consensus‐based recommendations for clinical presentation, diagnosis and assessment and management of people with CIPN. These recommendations aim to help guide podiatrists in the consistent care of people with CIPN.
Studying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach
Authors: Illipse Maya , Czene Kamila , Hall Per , Humphreys Keith 
Published: June 2023

AbstractBackgroundResearchers have suggested that longitudinal trajectories of mammographic breast density (MD) can be used to understand changes in breast cancer (BC) risk over a woman’s lifetime. Some have suggested, based on biological arguments, that the cumulative trajectory of MD encapsulates the risk of BC across time. Others have tried to connect changes in MD to the risk of BC.MethodsTo summarize the MD–BC association, we jointly model longitudinal trajectories of MD and time to diagnosis using data from a large ($$N = 40{,}087$$N=40,087) mammography cohort of Swedish women aged 40–80 years. Five hundred eighteen women were diagnosed with BC during follow-up. We fitted three joint models (JMs) with different association structures; Cumulative, current value and slope, and current value association structures.ResultsAll models showed evidence of an association between MD trajectory and BC risk ($$P < 0.001$$P<0.001for current value of MD,$$P < 0.001$$P<0.001and$$P =0.005$$P=0.005for current value and slope of MD respectively, and$$P < 0.001$$P<0.001for cumulative value of MD). Models with cumulative association structure and with current value and slope association structure had better goodness of fit than a model based only on current value. The JM with current value and slope structure suggested that a decrease in MD may be associated with an increased (instantaneous) BC risk. It is possible that this is because of increased screening sensitivity rather than being related to biology.ConclusionWe argue that a JM with a cumulative association structure may be the most appropriate/biologically relevant model in this context.
Atrial fibrillation induced by gabapentin: a case report
Authors: Park Sung Hwan , Hunter Kristen , Berry Hugh , Martins Yuri Chaves 
Published: June 2023

AbstractBackgroundGabapentin is commonly prescribed for the treatment of neuropathic pain, restless leg syndrome, and partial-onset seizures. Although the most frequent side effects of gabapentin are associated with the central nervous system, gabapentin can also affect the cardiovascular system. Case reports and observational studies have showed that gabapentin can be associated with increased risk of atrial fibrillation. However, all the evidence is concentrated in patients older than 65 years old with comorbidities that predispose them to the development of arrhythmias.Case presentationWe describe a case of an African American male in his 20s that presented to our chronic pain clinic with lumbar radiculitis and developed atrial fibrillation 4 days after being started on gabapentin. Laboratory workup did not show significant abnormalities, including normal complete blood count, comprehensive metabolic panel, toxicology screen, and thyroid-stimulating hormone. Transthoracic and transesophageal echocardiography showed a patent foramen ovale with right-to-left shunt. The patient was initially treated with diltiazem for heart rate control and apixaban. Direct current cardioversion with successful conversion to sinus rhythm was performed 24 hours after admission. The patient was then discharged on apixaban and diltiazem. Apixaban was changed to low-dose aspirin 1 month after discharge.ConclusionWith rapidly increasing usage of gabapentin for approved and off-label indications, it is important to identify unintended adverse effects of this drug as they are considered safe alternatives to opioids. New-onset atrial fibrillation could be induced by gabapentin in young individuals.
Effects of concurrent and cumulative group dynamic assessments on EFL learners’ development of reading comprehension micro-skills
Authors: Zadkhast Mahtab , Rezvani Ehsan , Lotfi Ahmad Reza 
Published: June 2023

AbstractThe current study set out to investigate the effects of concurrent group dynamic assessment (GDA) and cumulative GDA on Iranian EFL learners’ development of reading comprehension micro-skills. To this end, a convenience sample of 60 intermediate undergraduate EFL university students that were selected based on the results of a placement test and randomly assigned to two experimental groups participated in the study. The participants met once a week for 90-min lessons in a Reading II class over an academic semester. Each group received a concurrent or cumulative GDA mediation on reading tasks with a focus on activities involving five fundamental reading comprehension micro-skills, namely identifying the main idea, finding inferences, finding supporting details, understanding vocabulary, and finding references. A pretest/posttest procedure was used to compare the two group’s achievements. The results of t test analyses demonstrated that both GDA approaches were effective but the students in the concurrent GDA group significantly outperformed those in the cumulative GDA group in terms of micro-skills of identifying the main idea and finding inferences whereas no significant differences were observed for other micro-skills. It could be argued that in concurrent GDA since the secondary interactants expect to be called on at any moment, they are more alert and attentive to mediational exchanges, and this contributes to enriching the micro-skills of identifying the main idea and finding inferences. The findings suggest that concurrent and cumulative GDA approaches when applied to teaching reading comprehension should be viewed as complementary. The concurrent approach works better with activities that require higher-cognitive functions and top-down processes such as identifying main ideas or finding inferences. On the other hand, both approaches could be equally beneficial and interchangeably used in activities that involve lower-level bottom-up cognitive processes such as finding supporting details, understanding vocabulary, or finding references. The findings offer significant implications for classroom practice and subsequent research that are discussed.
Intracellular lipophilic network transformation induced by protease-specific endocytosis of fluorescent Au nanoclusters
Authors: Ku Minhee , Yang Jaemoon 
Published: June 2023

AbstractThe understanding of the endocytosis process of internalized nanomedicines through membrane biomarker is essential for the development of molecular-specific nanomedicines. In various recent reports, the metalloproteases have been identified as important markers during the metastasis of cancer cells. In particular, MT1-MMP has provoked concern due to its protease activity in the degradation of the extracellular matrix adjacent to tumors. Thus, in the current work, we have applied fluorescent Au nanoclusters which present strong resistance to chemical quenching to the investigation of MT1-MMP-mediated endocytosis. We synthesized protein-based Au nanocluster (PAuNC) and MT1-MMP-specific peptide was conjugated with PAuNC (pPAuNC) for monitoring protease-mediated endocytosis. The fluorescence capacity of pPAuNC was investigated and MT1-MMP-mediated intracellular uptake of pPAuNC was subsequently confirmed by a co-localization analysis using confocal microscopy and molecular competition test. Furthermore, we confirmed a change in the intracellular lipophilic network after an endocytosis event of pPAuNC. The identical lipophilic network change did not occur with the endocytosis of bare PAuNC. By classification of the branched network between the lipophilic organelles at the nanoscale, the image-based analysis of cell organelle networking allowed the evaluation of nanoparticle internalization and impaired cellular components after intracellular accumulation at a single-cell level. Our analyses suggest a methodology to achieve a better understanding of the mechanism by which nanoparticles enter cells.
Which STEM careers are most appealing? Examining high school students’ preferences and motivational beliefs for different STEM career choices
Authors: Rosenzweig Emily Q. , Chen Xiao-Yin 
Published: June 2023

AbstractBackgroundDecades of research have examined what motivates students to pursue careers in science, technology, engineering, and mathematics (STEM) fields, but STEM careers are a broad category encompassing hundreds of distinct vocations. The present study examined high school students’ relative preferences for pursuing some types of STEM careers over others and explored what motivational beliefs (defined in accordance with situated expectancy value theory) most influenced students’ relative career preferences. A secondary goal was to examine whether there were differences in any patterns as a function of students’ intersecting gender and racial/ethnic identities. A large sample of high school students (N = 526) completed an online survey during class time about their beliefs regarding fifteen different STEM career categories.ResultsStudents’ career preferences could be classified into four groups: appealing, unappealing, polarizing, or overlooked. The last category was the most common. Students primarily selected reasons related to utility and attainment value in influencing their choices of most- and least-preferred careers. However, within this category, beliefs about helping others were stronger influences on choosing most-preferred careers, whereas concerns about fitting in were more influential for choosing least-preferred careers. Gender and racial/ethnic comparisons suggest differentiation in how students think about the appeal of various career paths as early as high school.ImplicationsFindings shed light on how students come to perceive some STEM career paths as relatively more appealing than others, with attention to gender and racial/ethnic differences in these processes. Findings also point to specific and actionable ideas for how teachers, counselors, and administrators can target career education to cultivate students’ interest in STEM career paths, where there are particular needs.
Unified approach for evaluation of horizontal site amplification factors with special reference to history of studies on the effects of surface geology on seismic motion
Authors: Kawase Hiroshi , Nakano Kenichi , Nagashima Fumiaki , Ito Eri , Sun Jikai , Wang Ziqian 
Published: June 2023

AbstractFollowing the 1923 Kanto earthquake in Japan, Japanese researchers noticed the strong effects of surface geology on seismic motion (ESG) and began to investigate these effects to quantify the site amplification factors (SAFs) associated with soft surface sediments. On the other side of the Pacific Ocean, ESG received limited attention until the 1985 Michoacan, Mexico earthquake revealed significant long-period amplification inside Mexico City that manifested as the source of devastating damage to high-rise buildings. Since then, seismologists and earthquake engineers have performed a lot of studies on various ESG issues worldwide. We have not yet reached common conclusions on how to quantitatively predict SAFs over a broad frequency band of engineering interest, 0.1 to 20 Hz, for moderate to strong input from different types of earthquakes in different tectonic settings. However, we found here several basic guidelines useful for successfully modeling ground motions as a common approach to ESG studies. First, in this letter, we briefly review our history of understanding ESG, which is closely related to the key settings required for reliable quantifications of SAFs, and then introduce various emerging techniques for broadband quantitative evaluations of SAFs based on the vast amount of observed ground motions primarily from dense Japanese strong-motion networks. Based on the findings of our investigation and the physical relationships behind the parameters, the authors would like to recommend that researchers on ESG and related topics would refer to the five basic guidelines proposed in the conclusions for the successful implementation of techniques to delineate SAFs in a specific region of interest, such as the use of Fourier spectra instead of response spectra. We have started applying the proposed techniques to regions outside Japan. The implementation of the statistical validation exercises will follow.
Graphical Abstract
A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities
Authors: Ortega Miguel A. , Fraile-Martinez Oscar , García-Montero Cielo , Haro Sergio , Álvarez-Mon Miguel Ángel , De Leon-Oliva Diego , Gomez-Lahoz Ana M. , Monserrat Jorge , Atienza-Pérez Mar , Díaz David , Lopez-Dolado Elisa , Álvarez-Mon Melchor 
Published: June 2023

AbstractSpinal cord injury (SCI) is a devastating and disabling medical condition generally caused by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage (secondary injury). The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI, explaining the progression and detrimental consequences related to this condition. Psychoneuroimmunoendocrinology (PNIE) is a growing area of research aiming to integrate and explore the interactions among the different systems that compose the human organism, considering the mind and the body as a whole. The initial traumatic event and the consequent neurological disruption trigger immune, endocrine, and multisystem dysfunction, which in turn affect the patient’s psyche and well-being. In the present review, we will explore the most important local and systemic consequences of SCI from a PNIE perspective, defining the changes occurring in each system and how all these mechanisms are interconnected. Finally, potential clinical approaches derived from this knowledge will also be collectively presented with the aim to develop integrative therapies to maximize the clinical management of these patients.