bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zinc oxide nanoparticles functionalized with curcumin supplementation during in vitro embryo culture impaired in a concentration‐dependent‐manner blastocyst production in cattle
Authors: Miglio Luisa , Novaes Marco Aurélio Schiavo , de Lima Laritza Ferreira , Arantes Tatiane Moraes , Alves Kele Amaral , Dias Francisca Elda Ferreira , Beletti Marcelo Emílio , de Figueiredo José Ricardo 
Published: June 2023

AbstractThis work investigated the effect of zinc oxide nanoparticles functionalized with curcumin (ZnO(np) + CUR) supplementation during the in vitro embryo culture (IVC) on the bovine in vitro embryo production, and the cellular antioxidant response. The cumulus–oocyte complexes (COCs) were matured, fertilized and then the presumptive zygotes were cultured in the medium in the absence (0 μM—control) or presence of different concentrations of ZnO(np) + CUR (3, 6 or 12 μM). After IVC, the embryos were destined either to assay intracellular ROS levels and mitochondrial membrane potential. The results demonstrated that only the addition of 12 μM ZnO(np) + CUR during IVC decreased intracellular ROS production and the rate of blastocyst production when compared to the control (p < .05). In conclusion, ZnO(np) + CUR addition during the IVC impaired in concentration‐dependent‐manner bovine in vitro embryo production.
Multiphase solutions and their reductions for a nonlocal nonlinear Schrödinger equation with focusing nonlinearity
Authors: Matsuno Yoshimasa 
Published: June 2023

AbstractA nonlocal nonlinear Schrödinger equation with focusing nonlinearity is considered, which has been derived as a continuum limit of the Calogero–Sutherland model in an integrable classical dynamical system. The equation is shown to stem from the compatibility conditions of a system of linear partial differential equations (PDEs), assuring its complete integrability. We construct a nonsingular N‐phase solution (N: positive integer) of the equation by means of a direct method. The features of the one‐ and two‐phase solutions are investigated in comparison with the corresponding solutions of the defocusing version of the equation. We also provide an alternative representation of the N‐phase solution in terms of solutions of a system of nonlinear algebraic equations. Furthermore, the eigenvalue problem associated with the N‐phase solution is discussed briefly with some exact results. Subsequently, we demonstrate that the N‐soliton solution can be obtained simply by taking the long‐wave limit of the N‐phase solution. The similar limiting procedure gives an alternative representation of the N‐soliton solution as well as the exact results related to the corresponding eigenvalue problem.
An asymptotic expansion of eigenpolynomials for a class of linear differential operators
Authors: Borrego‐Morell Jorge A. 
Published: June 2023

AbstractConsider an M‐th order linear differential operator, ,where is a monic complex polynomial such that and are complex polynomials such that . It is known that the zero counting measure of its eigenpolynomials converges in the weak star sense to a measure μ. We obtain an asymptotic expansion of the eigenpolynomials of in compact subsets out of the support of μ. In particular, we solve a conjecture posed in Masson and Shapiro [On polynomial eigenfunctions of a hypergeometric type operator. Exper Math. 2001;10:609‐618].
Cultural Niche Construction as a Framework for Reorienting Human−Environment Relations
Authors: Nagatsu Michiru , Kaaronen Roope O. , Salmela Mikko , MacLeod Miles 
Published: June 2023

AbstractIn this paper, we argue that the theory of cultural niche construction provides a cogent and fruitful framework for studying and managing human−environment relationships, including our conceptualizations of them. We first review the development of the ideas of niche construction from evolutionary to social contexts. We then discuss how various human cognitive and affective goals are achieved through our engagement and interaction with the environment, as cognitive and affective niche construction. We extend this analysis to the built environment, as urban niche construction, and provide two examples of urban design for which niche construction provides useful theoretical and practical insights. We also discuss how different urban policy initiatives are related through the lens of cultural niche construction.
Are Humans Part of the Natural World? U.S. Children's and Adults’ Concept of Nature and its Relationship to Environmental Concern
Authors: Pizza Lizette , Kelemen Deborah 
Published: June 2023

AbstractUnderstanding factors that promote conservation attitudes is essential given ongoing environmental crises and the need for sustainability. Our research adopted various close‐ and open‐ended tasks to explore: the extent to which U.S. urban adults (Study 1) and children (Study 2) have a basic conception of humans as part of nature, cognitive factors that predict more human‐inclusive concepts of nature, and, finally, the relationship of their nature concepts and other individual differences to environmental moral concern and biocentric reasoning. General environmental moral concern and biocentric moral reasoning were a focus because both variables have previously been linked to sustainable attitudes. Across studies, adults and children did not tend to categorize humans as part of nature except when induced or disposed to attribute mind or life to nature. Among adults, a human‐inclusive nature concept did not predict environmental moral concern or biocentrism. However, the degree of exposure to nature was positively predictive while a cluster of beliefs about humans as intrinsically unique, superior, and influential (human exceptionalism) was negatively predictive. Among children, a basic human‐inclusive concept of nature was related to environmental concern but only among children who also tended to reason in ecological terms. These findings have important implications for sustainability efforts: They suggest that environmental moral concern and biocentric attitudes may be enhanced over‐development by nature exposure and interventions that enduringly promote human‐inclusive concepts of nature and ecological‐systems understanding. Such intervention effects might be achieved by selectively inducing individuals to attribute mind and life to non‐human natural phenomena and scaffolding accurate mechanistic understanding of evolution and common ancestry, which may also help to inhibit the development and deleterious effects of human exceptionalism.
The mystery of misreported trade: A novel method to identify distorted trade figures
Authors: Farhad Mohammad , Madsen Jakob B. , Jetter Michael , Williams Andrew 
Published: June 2023

AbstractThis research shows that misreporting of trade is rampant, which markedly reduces the quality of reported bilateral trade data. We devise a novel methodology to correct for misreported bilateral trade while accounting for the composition of product types and for trading partners. Based on bilateral data for 196 countries in the world at the product level over the period 1996–2017, we find that (i) our corrected trade data are significantly more reliable than reported data; (ii) our corrected data are significantly more reliable than data based on conventional misreporting correction methods; (iii) corrected trade balances are often quite distinct from their reported counterparts; (iv) capital flight is the most important source of misreporting and (v) the misreporting propensity tends to cluster geographically, with the main offenders often deviating from common perceptions in the literature. Based on estimates of the gravity model, we show that geographical characteristics are more influential than institutional variables in explaining misreporting.
Age, CD34+ cell dose, conditioning and pre‐transplant cytopenias can help predict transfusion support in lymphoma patients undergoing autologous stem cell transplantation
Authors: Regalado‐Artamendi Isabel , García‐Fasanella Marta , Medina Laura , Fernandez‐Sojo Jesus , Esquirol Albert , García‐Cadenas Irene , Martino Rodrigo , Briones Javier , Sierra Jorge , Novelli Silvana 
Published: June 2023

AbstractBackground and ObjectivesAutologous stem cell transplant (ASCT) is a widely used therapy for lymphoma patients and can nowadays be performed on an outpatient basis. This study aimed to describe transfusion support in lymphoma patients undergoing ASCT and identify increased or prolonged transfusion requirement predictors.Materials and MethodsA retrospective study of all consecutive lymphoma patients undergoing ASCT between 2010 and 2020.ResultsOut of 226 patients, 145 (64%) received red blood cell (RBC) transfusions, whereas all 226 (100%) required platelet transfusion (PT). Transfusions between Day +1 and +30 were higher in patients over 60 (2 [1–4] vs. 2 [0–2] RBC; p = 0.001 and 4 [2–8] vs. 3 [2–4] PT; p < 0.001); patients with pre‐transplant anaemia (4 [2.5–6] vs. 2 [0–2] RBC; p < 0.001 and 5 [3–9] vs. 3 [2–4] PT; p = 0.001); pre‐transplant thrombocytopenia (2 [1–4] vs. 2 [0–2] RBC; p < 0.001 and 4 [3–8.5] vs. 2 [1–3] PT; p < 0.001) or CD34+ cell dose <4 × 106/kg (2 [0–4] vs. 2 [0–2] RBC; p = 0.024 and 4 [2–6] vs. 2 [1–3.5] PT; p < 0.001). RBC transfusion independence was reached later in patients receiving carmustine, cytarabine, etoposide and melphalan (BEAM) (hazard ratio [HR] 1.6; confidence interval [CI] 1.1–2.3) and those requiring RBC before infusion and/or with pre‐transplant anaemia (HR 2.2; CI 1.4–3.4). Age above 60 (HR 1.4; CI 1.0–1.9), BEAM conditioning (HR 1.4; CI 1.0–2.0) and pre‐transplant thrombocytopenia and/or requiring PT before infusion (HR 1.8; CI 1.4–2.5) entailed longer time until PT independence.ConclusionThese four factors (age ≥60 years; BEAM conditioning, CD34+ dose <4 × 106/kg and pre‐transplant cytopenia and/or Day −10 to 0 transfusion) allowed dividing patients into three groups with significant differences between them regarding the time until transfusion independence.
University Students’ Perceived Self-control and Prosocial Norms for Beneficial Social Media Use
Authors: Shahzalal Md , Adnan Hamedi M , Abdullah Fadli 
Published: June 2023

Although many studies have been conducted on social media abuse, socio-psychological determinants of positive social media usage are still underresearched, specifically concerning self-control and prosocial norms for university students. These two important antecedents of accountable behavior have not been thoroughly studied in developing countries. Therefore, the current study investigated university students’ perceptions of self-control and prosocial norms and determined whether they co-exist and are associated with intended behavior and desired beneficial usage. This study modified measurement items adopted from previous studies to fit the current context. A social media survey was conducted through Facebook Messenger among students from a public university in Bangladesh. 226 voluntary responses were recorded based on purposive sampling. The data were analyzed using SPSS and SmartPLS 4. Descriptive statistics were analyzed. Hypotheses were tested using the structural equation modeling technique, whereas the differential effects of gender and social media platforms were tested using ANOVA. The findings demonstrate that university students value self-control and prosocial norms as crucial determinants of positive social media behavior. These factors strongly correlate with intended self-control and prosocial behavior, and desired beneficial use. Additionally, gender and the type of social media platform used have no significant impact on these results. This study explored valuable insights into the role of self-control and prosocial norms in promoting beneficial social media use among university students, which may have significant implications for their personal and social well-being.
Effect of the P-Selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial
Authors: Solomon Scott D. , Lowenstein Charles J. , Bhatt Ankeet S. , Peikert Alexander , Vardeny Orly , Kosiborod Mikhail N. , Berger Jeffrey S. , Reynolds Harmony R. , Mavromichalis Stephanie , Barytol Anya , Althouse Andrew D. , Luther James F. , Leifer Eric S. , Kindzelski Andrei L. , Cushman Mary , Gong Michelle N. , Kornblith Lucy Z. , Khatri Pooja , Kim Keri S. , Baumann Kreuziger Lisa , Wahid Lana , Kirwan Bridget-Anne , Geraci Mark W. , Neal Matthew D. , Hochman Judith S. ,   for the ACTIV4a Investigators
Published: June 2023

BACKGROUND:
COVID-19 has been associated with endothelial injury, resultant microvascular inflammation and thrombosis. Activated endothelial cells release and express P-selectin and von Willebrand factor, both of which are elevated in severe COVID-19 and may be implicated in the disease pathophysiology. We hypothesized that crizanlizumab, a humanized monoclonal antibody to P-selectin, would reduce morbidity and death in patients hospitalized for COVID-19.

METHODS:
An international, adaptive, randomized controlled platform trial, funded by the National Heart, Lung, and Blood Institute, randomly assigned 422 patients hospitalized with COVID-19 with moderate or severe illness to receive either a single infusion of the P-selectin inhibitor crizanlizumab (at a dose of 5 mg/kg) plus standard of care or standard of care alone in an open-label 1:1 ratio. The primary outcome was organ support–free days, evaluated on an ordinal scale consisting of the number of days alive free of organ support through the first 21 days after trial entry.

RESULTS:
The study was stopped for futility by the data safety monitoring committee. Among 421 randomized patients with known 21-day outcomes, 163 patients (77%) randomized to the crizanlizumab plus standard-of-care arm did not require any respiratory or cardiovascular organ support compared with 169 (80%) in the standard-of-care–alone arm. The adjusted odds ratio for the effect of crizanlizumab on organ support–free days was 0.70 (95% CI, 0.43–1.16), where an odds ratio >1 indicates treatment benefit, yielding a posterior probability of futility (odds ratio <1.2) of 98% and a posterior probability of inferiority (odds ratio <1.0) of 91%. Overall, there were 37 deaths (17.5%) in the crizanlizumab arm and 27 deaths (12.8%) in the standard-of-care arm (hazard ratio, 1.33 [95% CrI, 0.85-2.21]; [probability of hazard ratio>1] = 0.879).

CONCLUSIONS:
Crizanlizumab, a P-selectin inhibitor, did not result in improvement in organ support–free days in patients hospitalized with COVID-19.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04505774.
Potential of machine learning approaches for predicting mechanical properties of spruce wood in the transverse direction
Authors: Chen Shuoye , Shiina Rei , Nakai Kazushi , Awano Tatsuya , Yoshinaga Arata , Sugiyama Junji 
Published: June 2023

AbstractTo predict the mechanical properties of wood in the transverse direction, this study used machine learning to extract the anatomical features of wood from cross-sectional stereograms. Specimens with different orientations of the ray parenchyma cell were prepared, and their modulus of elasticity (MOE) and modulus of rupture (MOR) were measured by a three-point bending test. The orientation of the ray parenchyma cell and wood density ($$\rho $$
ρ
) were used as parameters for the MOE and MOR prediction. Conventional machine learning algorithms and artificial neural network were used, and satisfactory results were obtained in both cases. A regular convolutional neural network (CNN) and a density-informed CNN were used to automatically extract anatomical features from the specimens’ cross-sectional stereograms to predict the mechanical properties. The regular CNN achieved acceptable but relatively low accuracy in both the MOE and MOR prediction. The reason for this may be that $$\rho $$
ρ
information could not be satisfactorily extracted from the images, because the images represented a limited region of the specimen. For the density-informed CNN, the average prediction coefficient for both the MOE and MOR drastically increased when $$\rho $$
ρ
information was provided. A regression activation map was constructed to understand the representative anatomical features that are strongly related to the prediction of mechanical properties. For the regular CNN, the latewood region was highly activated in both the MOE and MOR prediction. It is believed that the ratio and orientation of latewood were successfully extracted for the prediction of the considered mechanical properties. For the density-informed CNN, the activated region is different. The earlywood region was activated in the MOE prediction, while the transition region between the earlywood and latewood was activated in the MOR prediction. These results may provide new insights into the relationship between the anatomical features and mechanical properties of wood.
VCAM-1 complements CA-125 in detecting recurrent ovarian cancer
Authors: Song Jin , Sokoll Lori J. , Zhang Zhen , Chan Daniel W. 
Published: June 2023

Abstract
Background
Close to three-quarters of ovarian cancer cases are frequently diagnosed at an advanced stage, with more than 70% of them failing to respond to primary therapy and relapsing within 5 years. There is an urgent need to identify strategies for early detection of ovarian cancer recurrence, which may lead to earlier intervention and better outcomes.

Methods
A customized magnetic bead-based 8-plex immunoassay was evaluated using a Bio-Plex 200 Suspension Array System. Target protein levels were analyzed in sera from 58 patients diagnosed with advanced ovarian cancer (including 34 primary and 24 recurrent tumors) and 46 healthy controls. The clinical performance of these biomarkers was evaluated individually and in combination for their ability to detect recurrent ovarian cancer.

Results
An 8-plex immunoassay was evaluated with high analytical performance suitable for biomarker validation studies. Logistic regression modeling selected a two-marker panel of CA-125 and VCAM-1 that improved the performance of CA-125 alone in detecting recurrent ovarian cancer (AUC: 0.813 versus 0.700). At a fixed specificity of 83%, the two-marker panel significantly improved sensitivity in separating primary from recurrent tumors (70.8% versus 37.5%, P = 0.004), demonstrating that VCAM-1 was significantly complementary to CA-125 in detecting recurrent ovarian cancer.

Conclusions
A two-marker panel of CA-125 and VCAM-1 showed strong diagnostic performance and improvement over the use of CA-125 alone in detecting recurrent ovarian cancer. The experimental results warrant further clinical validation to determine their role in the early detection of recurrent ovarian cancer.
Impact of different CAD/CAM materials on internal and marginal adaptations and fracture resistance of endocrown restorations with: 3D finite element analysis
Authors: El-Farag Shaimaa Ahmed Abo , Elerian Fatma Abdallah , Elsherbiny Abdallah Ahmed , Abbas Mahy Hassouna 
Published: June 2023

Abstract
Purpose
To assess and compare the impact of various computers aided design/manufacturing (CAD/CAM) materials on internal and marginal discrepancies, fracture resistance and failure probability of Endocrown restorations with 3D Finite Element analysis.

Material and methods
Forty devitalized human maxillary first molars were collected. After endodontic treatment, they classified into 4 groups (n = 10) based on the materials used for endocrown fabrication. Group V (Vita-Enamic), Group N (Nacera Hybrid), Group T (Translucent Prettau Zirconia) and Group P (Pekkton ivory). All samples were exposed to artificial aging method simulating one year of clinical service. Silicone replica technique and stereomicroscope (25X) utilized to evaluate the marginal and internal gaps of endocrowns at different areas. Fracture resistance test used for cemented specimens followed by qualitative investigation utilizing Stereomicroscopy. Four models representing four endocrown systems used for restoration of severely-damaged endodontically treated upper first molar were generated for finite element analysis (FEA). Axially and centrally static occlusal compressive load was applied. Modified Von Mises and maximum principal stress values on the remaining tooth structure, cement lines and restorative materials were assessed independently. Resulted data were statistically analyzed at P-value ≤ 0.05.

Results
In the current study, the highest mean values of internal and marginal discrepancies (μm) among studied groups were reported for Zirconia group (100.300 and 102.650) respectively, while the lowest mean value of internal discrepancy (μm) was observed for Nacera group (69.275) and the lowest mean value of marginal discrepancy (μm) was observed for PEKK group (78.4750). Regarding internal discrepancy, Vita-Enamic and PEKK groups did not exhibit any statistically significant differences (P = 0.293), however zirconia and the other tested groups exhibited statistically significant differences in the mean values of the marginal gap region (p 0.05).On the other hand, PEKK group showed the highest mean value of fracture resistance (1845.20 N) and the lowest value was observed for Vita-Enamic group (946.50 N). Regarding to stress distributions through 3D FEA, and according to modified von Mises (mvM) analysis, the greatest possible stress values were noticed in PEKK model in relation to tooth structure, cement line, and flowable composite as the following: (93.1, 64.5, 58.4 MPa) respectively, while Zirconia revealed lower maximum stress values (11.4, 13.6, 11.6 MPa) respectively.

Conclusions
Statistically excellent marginal and internal fit was observed for PEKK in relation to other used endocrown materials. Also, PEKK material explained fracture resistance comparable to zirconia value while the lowest value was detected for Vita Enamic material.