bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes of corneal biomechanics in children using orthokeratology and their roles in predicting axial length progression—A prospective 2‐year study
Authors: Xiang Kaidi , Chen Jun , Zhao Wenchen , Zhu Zhuoting , Ding Li , Bulloch Gabriella , Du Linlin , Xu Xun , Zhu Mengjun , He Xiangui 
Published: March 2023

AbstractPurposeTo determine how orthokeratology (ortho‐k) affects corneal biomechanical properties in myopia control and whether corneal biomechanical parameters can predict clinical efficacy of ortho‐k.MethodsA total of 125 children 7–15 years of age using ortho‐k lenses were followed in this clinical practice and data of their right eyes were analysed. Corneal biomechanical parameters and most ocular biometry were measured at baseline, 1 week, and at 1, 3, 6, 12, 18 and 24 months. Axial length (AL) was collected every 6 months after baseline measurements.ResultsDuring the 2‐year follow up, nine corneal biomechanical parameters, including deformation amplitude maximum (DA), varied between baseline and 1 week (p < 0.05) and stabilized during the rest of wearing period (p > 0.05). The mean AL increased from 25.02 ± 0.84 mm to 25.38 ± 0.81 mm and baseline DA strongly correlated with AL progression (Pearson r = 0.37). In the multiple regression models, baseline age, AL and DA were the independent factors for AL progression (R2: 0.7849, 0.2180 in low and moderate myopes). The area under the receiver operating characteristic curves using the three variables for predicting excessive AL progression (>0.35 mm during 2 years) in low and moderate myopes was 0.902 and 0.698.ConclusionsCorneal biomechanics firstly fluctuated before becoming stable with long‐term ortho‐k use. Corneal biomechanics was associated with AL progression in children wearing ortho‐k lenses. DA combined with age and AL at baseline could predict AL progression in low myopes using ortho‐k.
Discussing depression in patients with visual impairment differs across countries: Validation of a prediction model in healthcare providers
Authors: van Munster Edine P. J. , van Nispen Ruth M. A. , Nollett Claire L. , Holloway Edith E. , Maarsingh Otto R. , Heymans Martijn W. , van der Aa Hilde P. A. 
Published: March 2023

AbstractPurposeHealthcare providers often experience difficulties in discussing depression with adults with visual impairment (VI), obstructing timely referral. The purpose of this study was to examine predictors of routine discussions of depression with adults with VI from the perspective of different healthcare providers from different countries.MethodsCross‐sectional survey data from Welsh (N = 122), Australian (N = 94) and Dutch (N = 100) healthcare providers, that is eye care practitioners (ECPs) and low‐vision care providers (LVCPs), were analysed. Multivariable logistic regression analysis was performed in the Welsh sample to determine predictors for discussing depression. Internal validation was conducted by using a bootstrap method, and the recalibrated model was externally validated in the Australian and Dutch sample.ResultsWork experience in eye care services (OR 0.95; 95% confidence interval (CI) 0.92 to 0.99) and perceived barriers (OR 0.95; 95% CI 0.92 to 0.98) was found to predict discussing depression with patients. The area under the curve (AUC) of 0.73 reflected good discrimination of the model. The model showed a slightly better fit in the Australian sample (AUC = 0.77), but a poor fit in the Dutch sample.ConclusionThe final prediction model was not generalizable to Dutch healthcare providers. They perceived less barriers in depression management than Welsh and Australian healthcare providers. This could be explained by differences in ECPs and LVCPs roles and responsibilities, increased attention on mental health and differences in organizing health care. Differences between healthcare providers' responsibilities and support needs should be taken into account while creating a facilitating environment to discuss depression.
Evidence for solanidine as a dietary CYP2D6 biomarker: Significant correlation with risperidone metabolism
Authors: Wollmann Birgit M. , Smith Robert L. , Kringen Marianne Kristiansen , Ingelman‐Sundberg Magnus , Molden Espen , Størset Elisabet 
Published: March 2023

AimsThe extensive variability in cytochrome P450 2D6 (CYP2D6) metabolism is mainly caused by genetic polymorphisms. However, there is large, unexplained variability in CYP2D6 metabolism within CYP2D6 genotype subgroups. Solanidine, a dietary compound found in potatoes, is a promising phenotype biomarker predicting individual CYP2D6 metabolism. The aim of this study was to investigate the correlation between solanidine metabolism and the CYP2D6‐mediated metabolism of risperidone in patients with known CYP2D6 genotypes.MethodsThe study included therapeutic drug monitoring (TDM) data from CYP2D6‐genotyped patients treated with risperidone. Risperidone and 9‐hydroxyrisperidone levels were determined during TDM, and reprocessing of the respective TDM full‐scan high‐resolution mass spectrometry files was applied for semi‐quantitative measurements of solanidine and five metabolites (M402, M414, M416, M440 and M444). Spearman's tests determined the correlations between solanidine metabolic ratios (MRs) and the 9‐hydroxyrisperidone‐to‐risperidone ratio.ResultsA total of 229 patients were included. Highly significant, positive correlationswere observed between all solanidine MRs and the 9‐hydroxyrisperidone‐to‐risperidone ratio (ρ > 0.6, P < .0001). The strongest correlation was observed for the M444‐to‐solanidine MR in patients with functional CYP2D6 metabolism, i.e., genotype activity scores of 1 and 1.5 (ρ 0.72–0.77, P < .0001).ConclusionThe present study shows strong, positive correlations between solanidine metabolism and CYP2D6‐mediated risperidone metabolism. The strong correlation within patients carrying CYP2D6 genotypes encoding functional CYP2D6 metabolism suggests that solanidine metabolism may predict individual CYP2D6 metabolism, and hence potentially improve personalized dosing of drugs metabolized by CYP2D6.
The role of decision tree and machine learning models for outcome prediction of bupropion exposure: A nationwide analysis of more than 14 000 patients in the United States
Authors: Mehrpour Omid , Saeedi Farhad , Vohra Varun , Abdollahi Jafar , Shirazi Farshad M. , Goss Foster 
Published: March 2023

AbstractBupropion is widely used for the treatment of major depressive disorder and for smoking cessation assistance. Unfortunately, there are no practical systems to assist clinicians or poison centres in predicting outcomes based on clinical features. Hence, the purpose of this study was to use a decision tree approach to inform early diagnosis of outcomes secondary to bupropion overdose. This study utilized a dataset from the National Poison Data System, a 6‐year retrospective cohort study on toxic exposures and patient outcomes. A machine learning algorithm (decision tree) was applied to the dataset using the sci‐kit‐learn library in Python. Shapley Additive exPlanations (SHAP) were used as an explainable method. Comparative analysis was performed using random forest (RF), Gradient Boosting classification, eXtreme Gradient Boosting, Light Gradient Boosting (LGM) and voting ensembling. ROC curve and precision–recall curve were used to analyse the performance of each model. LGM and RF demonstrated the highest performance to predict outcome of bupropion exposure. Multiple seizures, conduction disturbance, intentional exposure, and confusion were the most influential factors to predict the outcome of bupropion exposure. Coma and seizure, including single, multiple and status, were the most important factors to predict major outcomes.
Intravesical oncolytic virotherapy and immunotherapy for non‐muscle‐invasive bladder cancer mouse model
Authors: Smelser Woodson W. , Wang Jian , Ogden Kristen M. , Chang Sam S. , Kirschner Austin N. 
Published: March 2023

ObjectivesTo test if intravesical instillation of both an anti‐programmed cell death protein 1 (PD‐1) inhibitor and an oncolytic reovirus would demonstrate a greater effect than either treatment alone, as non‐muscle‐invasive bladder cancer that is refractory to intravesical bacillus Calmette–Guérin can be treated by systemic anti‐PD‐1 immunotherapy and we previously demonstrated improved overall survival (OS) with six once‐weekly instillations of intravesical anti‐PD‐1 in a murine model.Materials and MethodsUsing an orthotopic syngeneic C3H murine model of MBT2 urothelial bladder cancer, groups of 10 mice were compared between no treatment, intravesical anti‐PD‐1, intravesical oncolytic reovirus, or intravesical reovirus + anti‐PD‐1. A single intravesical treatment session was given. The primary outcome was OS, and the secondary outcomes included long‐term immunity and tumour–immune profile.ResultsWith a median follow‐up of 9 months, all mice that received no treatment died with a median survival of 41 days, while the comparison median OS was not reached for reovirus (hazard ratio [HR] 14.4, 95% confidence interval [CI] 3.9–32.6; P < 0.001), anti‐PD‐1 (HR 28.4, 95% CI 7.0–115.9; P < 0.001), and reovirus + anti‐PD‐1 (HR 28.4, 95% CI 7.0–115.9; P < 0.001). Monotherapy with anti‐PD‐1 or reovirus demonstrated no significant differences in survival (P = 0.067). Mass cytometry showed that reovirus + anti‐PD‐1 treatment enriched monocytes and decreased myeloid‐derived suppressor cells, generating an immuno‐responsive tumour microenvironment. Depletion of CD8+ T cells eliminated the survival advantage provided by the intravesical treatment.ConclusionsTreatment of murine orthotopic bladder tumours with a single instillation of intravesical reovirus, anti‐PD‐1 antibody, or the combination confers superior survival compared to controls. Tumour–immune microenvironment differences indicated myeloid‐derived suppressor cells and CD8+ T cells mediate the treatment response.
Bilateral longitudinally extensive optic perineuritis post‐COVID‐19 presenting as “idiopathic” intracranial hypertension: A case report
Authors: Aladawi Mohammad , Crespo Daniel , Xu Renfeng , Zabad Rana , Vuppala Amrita‐Amanda 
Published: March 2023

AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARSCoV2) has been associated with several neuro‐ophthalmic manifestations. We report a case of bilateral longitudinally extensive optic perineuritis suspected due to SARSCoV2.Case PresentationA 32‐year‐old woman developed headaches, photophobia, pulsatile tinnitus, and blurred vision 8 d after having a positive SARS‐CoV‐2 qualitative polymerase chain reaction (PCR) testing for coronavirus disease 2019 (COVID‐19). She was diagnosed with and treated for idiopathic intracranial hypertension (IIH) elsewhere. Repeat evaluation at our institution showed a poor visual acuity in both eyes with Frisen grade II papilledema and cotton wool spots on fundoscopic examination. Orbital magnetic resonance imaging (MRI) showed bilateral longitudinally extensive optic nerve sheath enhancement. Repeat lumbar puncture revealed an elevated cerebrospinal fluid (CSF) opening pressure and protein, a finding that is incompatible with the diagnosis of IIH. Myelin oligodendrocyte glycoprotein, aquaporin‐4 (AQP4)‐IgG antibodies, and other serological tests for optic neuritis were unremarkable. Her visual acuity partially improved after corticosteroids. With the growing association of demyelinating disorders and COVID‐19, unremarkable serological workup, and temporal relation of the patient's symptoms to the infection, we believe that her diagnosis is SARS‐CoV‐2 associated bilateral optic neuritis.ConclusionThere is a growing association between demyelinating disorders and COVID‐19 and COVID‐19 vaccination, and it is essential to recognize CSF abnormalities that are incompatible with a diagnosis of IIH, such as increased protein in our case, and may lead to an incorrect diagnosis.
A comprehensive view on the quercetin impact on bladder cancer: Focusing on oxidative stress, cellular, and molecular mechanisms
Authors: Golmohammadi Maryam , Elmaghraby Dalia Ahmed , Ramírez‐Coronel Andrés Alexis , Rakhimov Nodir , Mohammed Shahad Saad , Romero‐Parra Rosario Mireya , Jawad Mohammed Abed , Zamanian Mohammad Yasin , Soltani Afsaneh , Taheri Niloofar , Kianifar Farzaneh , Vousooghi Nasim 
Published: March 2023

AbstractBladder cancer (BC) is known as a prevalent genitourinary malignancy and has a significant mortality rate worldwide. Despite recent therapeutic approaches, the recurrence rate is high, highlighting the need for a new strategy to reduce the BC cell progression. Quercetin, a flavonoid compound, demonstrated promising anticancer properties and could be used in the management of various malignancies such as BC. This comprehensive review summarized quercetin's cellular and molecular mechanisms underlying anticancer activities. The study's findings indicated that quercetin prevents the proliferation of the human BC cell line, promotes apoptosis of BIU‐87 cells, reduces the expression of p‐P70S6K, and induces apoptosis by p‐AMPK. Moreover, quercetin restricts tumor growth through the AMPK/mTOR cascade and prevents colony formation of human BC cells by triggering DNA damage. Studying this review article will help researchers better understand quercetin's functional role in the prevention and treatment of BC.
Lower cognitive function as a risk factor for anemia among older Japanese women from the longitudinal observation in theSONICstudy
Authors: Noma Tomoko , Kayo Godai , Kabayama Mai , Gondo Yasuyuki , Yasumoto Saori , Masui Yukie , Sugimoto Ken , Akasaka Hiroshi , Takami Yoichi , Takeya Yasushi , Yamamoto Koichi , Ikebe Kazunori , Arai Yasumichi , Ishizaki Tatsuro , Rakugi Hiromi , Kamide Kei 
Published: March 2023

AimThe aging‐related increase in the incidence of anemia potentially affects the mortality risk. Lower cognitive function is common among older adults, and anemia is one of the causes of cognitive decline. However, to the best of our knowledge, no study has investigated whether cognitive decline is a risk factor for anemia in older people. Therefore, in this study, we used a 3‐year longitudinal evaluation to examine the association of cognitive function with anemia in community‐dwelling older adults.MethodsThis longitudinal study enrolled participants without anemia (diagnosed based on the World Health Organization's criteria) at baseline. Cognitive function was assessed using the Japanese version of the Montreal Cognitive Assessment. Multiple logistic regression models were used to examine the association between cognitive function at baseline and the presence of anemia 3 years later.ResultsParticipants were in the 69–71 and 79–81 years age groups, and 974 older people (48.6% men) were enrolled, of whom 126 (12.9%) had anemia after 3 years. After adjusting, cognitive function at baseline was associated with anemia in women, but not in men.ConclusionsOlder Japanese women with lower cognitive function have an increased risk for anemia 3 years later. The adoption of a lifestyle that utilizes or improves cognitive function might be important to prevent anemia in older women.Geriatr Gerontol Int 2023; 23: 334–340.
THE (QUEER) AESTHETICS OF JEAN PAUL'S SIEBENKÄS
Authors: Sathi Anchit 
Published: March 2023

ABSTRACTThis article proposes that the eighteenth‐century novel Siebenkäs contains the formulation of an aesthetic theory that embraces same‐sex desire. The novel's author, Jean Paul Friedrich Richter, still relatively unknown among literary scholars today, uses the myth of Narcissus as an aesthetic blueprint for the novel. In doing so, he appears to comply with the aesthetic conventions espoused by his German Romantic peers, many of whom considered self‐contemplation to be a prerequisite for gaining access to the Absolute, a term that designates an unconditioned totality that was dear to authors, artists and philosophers at the time. However, the article suggests that Jean Paul's true purpose is to employ the myth to subversive ends. In particular, the author builds upon the myth's homoerotic underpinnings – largely (but not entirely) forgotten in the eighteenth century – to articulate a theory of aesthetics that no longer seeks to efface homosexual desire. The aesthetic worldview that emerges from this process is one that foregrounds imitation as a fundamental building‐block of queer aesthetics and that, in contraposition to some of the dominant aesthetic thinking of the age, advocates the legitimacy of an aesthetics that celebrates desire rather than suppressing it.
Demonstration of a Principal Component Analysis Trajectory Method to Assess Bioremediation Progress at a TCE‐Impacted Site
Authors: Freedman Matan , Mumford Kevin G. , Danko Anthony , Hart Dylan , Richardson Stephen D. 
Published: March 2023

AbstractIn‐situ bioremediation (ISB) is a popular remediation technology for the treatment of a range of compounds, including chlorinated solvents such as tetrachloroethene and trichloroethene (TCE). Large amounts of data are collected before, during, and after ISB applications to determine amendment approaches, monitor progress and evaluate success. The interpretation of these large datasets can be limited by the tools and techniques used for data analysis, and there is considerable potential in applying data reduction and multivariate techniques used elsewhere to performance monitoring during ISB. In this study, a principal component analysis (PCA) trajectory method was applied to a TCE‐impacted ISB site dataset, as an alternative to the inspection of time series data. The method connected each monitoring well's scores through PCA space to account for temporal changes in multiple analytes across the site. The method was used to separate monitoring well locations into categories that included On‐track and Unsuccessful based on their similarity to background wells in PCA space. The results agreed with those generated using traditional methods (e.g., time series plots) and were able to efficiently summarize large amounts of data to facilitate interpretation. It is expected that this PCA trajectory method could provide a useful screening tool to quickly identify site‐wide trends for the evaluation of ISB performance.
Physicochemical changes in red wines from the São Francisco Valley (Brazil) after aged in a bottle
Authors: de Lima Pedro Henrique Nascimento , Rodrigues Caroline Falcão , de Arruda José Humberto Barros , Santos Andrelina Maria Pinheiro , de Andrade Lima Luciana Leite 
Published: March 2023

SummaryThe São Francisco Valley is an exponent region in biotechnology and viticulture, located in the Northeast of Brazil, with tropical cultivation of wine grapes, with more than one harvest a year. Furthermore, wine production in the caatinga biome is unique and has shown commercial potential. Studies related to the physicochemical characterization and stability of wines during aging in the bottle are essential to guarantee and maintain quality. The present study aims to evaluate changes in physicochemical and chromatic parameters of tropical red wines from the São Francisco Valley aging in bottle. Classical physicochemical analyses, profiles of groups of phenolic compounds, antioxidant activity, and chromatic parameters were performed on all red wines from the São Francisco Valley Indication of Origin, with and without storage in oak barrels, and aged in bottles for 36 months. The study showed significant reductions in the levels of physicochemical parameters (acidity, total soluble solids, characterization of phenolic composition, antioxidant power) and color for wines that did not age in oak barrels. However, wines stored in oak barrels showed the highest stability. Thus, red wine storage in oak barrels, an oenological practice that increases quality, can be indicated for tropical red wines.
De‐gendering parents: Gender inclusion and standardised language in screen‐level bureaucracy
Authors: Höglund Frida , Flinkfeldt Marie 
Published: March 2023

AbstractSwedish welfare organisations have a long history of promoting gender equality and inclusivity, involving implementation of more gender‐inclusive language (e.g., non‐gendered terminology). This study analysed the use of non/gendered expressions at the Swedish Social Insurance Agency, as state policy is realised in conjunction with personalised service in textual interaction in screen‐level bureaucracy. We drew on conversation analysis and membership categorisation analysis to analyse 378 email interactions between clients and social insurance officers, focusing on gendered institutional terminology and gendered person references. The findings suggest that social insurance officers avoided a heteronormative language, in line with Swedish official public language policy, but that a gender‐neutral language may come at the cost of formality, standardisation, and de‐personalisation. The study brings new knowledge on the ways in which street‐level bureaucrats manage responsiveness and standardisation in digital text‐based interaction with clients.
Comparing survey data to qualitative themes in patient stories to help researchers better identify pressing community healthcare needs
Authors: Shah Vrusha K. , Hamm Megan , Glynn Nancy W. , Rockette‐Wagner Bonny , McTigue Kathleen 
Published: March 2023

AbstractBackgroundNarrative medicine is a powerful approach for strengthening clinicians' therapeutic alliances with patients and helping them understand others' perspectives by giving patients a voice. MyPaTH Story Booth is a cross‐sectional observational study that uses narrative medicine concepts to allow community participants to share their health and healthcare‐related experiences through relatively unstructured interviews (i.e., stories). The archive forms a qualitative research ʻcommonsʼ where researchers can learn about patient and caregiver perspectives and tailor research goals to better address community needs. Brief surveys allow storytellers to classify their stories so that the archive is searchable.MethodsThis study assessed sensitivity, specificity, positive predictive and negative predictive values of self‐reported surveys for categorizing 83 stories, compared with a ʻgold standardʼ (most commonly accepted method for interpreting narratives) of qualitative coding. Stories were classified as either having or not having each of 38 different classifications based on US National Library of Medicine (NLM) Health Topics (Type of disorder or condition and Part of the body discussed) or developed with stakeholder input (Type of health/healthcare experience).ResultsSurvey data assessing ʻPart of the body discussedʼ and ʻType of disorder or conditionʼ typically was highly sensitive (64%–95%) and specific (73%–99%) suggesting high adequacy of surveys in identifying stories. Questions focused on ʻType of health/healthcare experienceʼ showed inconsistent and relatively lower sensitivities (48%–93%) and specificities (30%–79%) suggesting lower adequacy of surveys in identifying stories.ConclusionSurvey items based on NLM Health Topics allowed people to categorize their health narratives into relevant, searchable topics making the database more accessible.