bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating blockchain capabilities in an omnichannel healthcare system: A dual theoretical perspective
Authors: Sangal Shreya , Nigam Achint , Sharma Sangeeta 
Published: July 2023

AbstractThe COVID‐19 pandemic opened a market for omnichannel healthcare. While some patients trusted the hybrid mode of consultancy, others lacked trust in the online mode of consultancy. The purpose of the study is to understand the extent to which blockchain can influence the swift trust of stakeholders and the usage intention of omnichannel healthcare systems (OHS). We used a quantitative approach by surveying 250 patients that rendered services from OHS by drawing upon the lens of organizational information processing theory (OIPT) and swift trust theory (STT). We test the hypotheses using the PLS‐SEM technique. The results show blockchain technology can significantly affect the adoption of omnichannel healthcare by reinforcing swift trust in OHS and its continued usage.
RGMb impacts partial epithelial‐mesenchymal transition and BMP2‐Induced ID mRNA expression independent of PD‐L2 in nonsmall cell lung cancer cells
Authors: Dorset Sofie Rahbek , Daugaard Tina Fuglsang , Larsen Trine Vilsbøll , Nielsen Anders Lade 
Published: July 2023

AbstractPD‐1/PD‐ligand‐axis immunotherapy‐mediated activation of T‐cells for cancer cell elimination is a promising treatment of nonsmall cell lung cancer (NSCLC). However, the effect of immunotherapy on intracellular signaling pathways in cancer cells still needs further delineation. Repulsive Guidance Molecule b (RGMb), a regulator of Bone Morphogenetic Proteins (BMPs) signaling, interacts with the PD‐ligand, PD‐L2, at cancer cell membranes. Accordingly, a clarification of the functions of RGMb and its relation to PD‐L2 might provide insight into NSCLC cell signaling responses to PD‐1/PD‐ligand‐axis immunotherapy. In this study, the functions of RGMb and PD‐L2 were examined using the two NSCLC cell lines HCC827 and A549. CRISPR/Cas9 was used to decrease the expression of RGMb and PD‐L2, while lentiviral vectors were used to increase their expression. Downstream effects were examined by RT‐qPCR and immunoassays. Ectopic expression of RGMb impacted BMP2‐induced expression of ID1 and ID2 messenger RNA (mRNA) independently of PD‐L2, while RGMb depletion by CRISPR/Cas9 did not affect the BMP2‐mediated induction of ID1, ID2, and ID3 mRNA. However, depletion of RGMb resulted in a partial epithelial‐mesenchymal transition (EMT) gene expression profile in HCC827 cells, which was not mimicked by PD‐L2 depletion. The results show that RGMb is a coregulator of BMP signaling and hence, ID mRNA expression and that RGMb can control the EMT balance in NSCLC cells. However, RGMb appears to exert these functions independently of PD‐L2, and accordingly, the PD‐1/PD‐ligand axis for immune surveillance in NSCLC cells.
Atomistic Distribution of Iron and Copper in Coordination Metallopolymer for Highly Efficient and Stable Hydrogen Evolution in Protic Media
Authors: Vishwa Prashanth , Babbet Charles , Reddy Bhargav , Kotoky Debabrat , Gopinathan Sarada K. , Udachyan Iranna , R S Vishwanath , Kandaiah Sakthivel 
Published: July 2023

AbstractMultifunctional aromatic linker ligands are crucial for designing robust heterogeneous electrocatalytic systems with an effective surface distribution of atomic redox active sites. Herein, we report the chemical immobilization of hetero‐metal ions (Fe and Cu) containing metallopolymers on copper surface as a low overpotential and stable electrocatalyst in acidic electrolyte. The sulfur and nitrogen‐rich triazine trithiolate ligand enables the active sites atomistic distribution through coordination linkage and displays an impressive low overpotential of −94 mV vs. RHE to attain −10 mA cm−2 in 0.5 M H2SO4. It is almost 103 times higher hydrogen evolution current densities than the copper substrate. The increased iron content and activation in acidic electrolyte reduce the overpotential and increase the electrochemical active surface area and catalytic activity. The long‐term hydrogen evolution suggests excellent stability in strong acidic electrolytes, and the film remains adherent to the substrate at higher hydrogen evolution current densities of −500 mA cm−2 and −700 A gm−1.
Photolysis of an Archetypal Model Complex. Photooxidation Versus Photoreduction of Azido(porphinato)iron(III)
Authors: Flesch Stefan , Vöhringer Peter 
Published: July 2023

AbstractAzidoporphinatoiron(III) ([1]) is an archetypal model complex for the photochemical generation of nitridoiron(V) complexes via cleavage of dinitrogen. So far, this process has only been studied with continuous irradiation in thin films under cryogenic conditions or in frozen solutions. In addition, the photooxidation from iron(III) to iron(V) competes with photoreduction to iron(II) via cleavage of an azidyl radical. The quantum yields of both pathways remained hitherto undisclosed. Here, we investigated the photolysis of this model complex in room temperature liquid solution using stationary and time‐resolved infrared spectroscopy. The two reaction pathways are unambiguously identified in quenching studies and their quantum yields are accurately determined. Nitridoporphinatoiron(V) ([2]) exhibits N‐atom‐2‐electron‐transfer reactivity toward tert‐butyl isonitrile and forms a carbodiimido species. In the presence of tert‐butyl isonitrile, the two products of the photoreduction pathway react to cationic diisonitriloporphinatoiron(III) and azide anions, which in turn combine to reform [1] and the quencher.
Synergistic Promotion of Large‐Current Water Splitting through Interfacial Engineering of Hierarchically Structured CoP−FeP Nanosheets with Rich P Vacancies
Authors: Qi Luoluo , Huang Zhiyang , Liao Miao , Wang Lei , Wang Lixia , Gao Mingcheng , Taylor Isimjan Tayirjan , Yang Xiulin 
Published: July 2023

AbstractThe development of hydrogen evolution reaction (HER) catalysts with high performance under large current density is still a challenge. Introducing P vacancies in heterostructure is an appealing strategy to enhance HER kinetics. This study investigates a CoP−FeP heterostructure catalyst with abundant P vacancies (Vp−CoP−FeP/NF) on nickel foam (NF), which was prepared using dipping and phosphating treatment. The optimized Vp−CoP−FeP catalyst exerted prominent HER catalytic capability, requiring an ultra‐low overpotential (58 mV @ 10 mA cm−2) and displaying robust durability (50 h @ 200 mA cm−2) in 1.0 M KOH solution. Furthermore, the catalyst demonstrated superior overall water splitting activity as cathode, demanding only cell voltage of 1.76 V at 200 mA cm−2, outperforming Pt/C/NF(−) || RuO2/NF(+). The catalyst‘s outstanding performance can be attributed to the hierarchical structure of porous nanosheets, abundant P vacancies, and synergistic effect between CoP and FeP components, which promote water dissociation and H* adsorption and desorption, thereby synergically accelerating HER kinetics and enhancing HER activity. This study demonstrates the potential of HER catalysts with phosphorus‐rich vacancies that can work under industrial‐scale current density, highlighting the importance of developing durable and efficient catalysts for hydrogen production.
Synthesis and Crystallographic Characterization of Helical Hairpin Oligourea Foldamers
Authors: Pendem Nagendar , Nelli Yella‐Reddy , Cussol Léonie , Didierjean Claude , Kauffmann Brice , Dolain Christel , Guichard Gilles 
Published: July 2023

AbstractInvited for the cover of this issue is the group of Gilles Guichard at the University of Bordeaux. The image depicts sketches and technical drawing tools to illustrate the creation and precise characterization of foldamer tertiary structures. Read the full text of the article at 10.1002/chem.202300087.
The association between lipoprotein(a) and atrial fibrillation: A systemic review and meta‐analysis
Authors: Yang Mingyang , Nasr Basma , Liu Junzhao , Du Yu , Yang Jiayin 
Published: July 2023

AbstractLipoprotein(a) (Lp[a]) is a particle consisting of a low‐density lipoprotein (LDL)‐like core connected to an apolipoprotein(a) chain, which is an established risk factor for cardiovascular disease. However, studies addressing the relationship between atrial fibrillation (AF) and Lp(a) demonstrated conflicted results. Thus, we sought to evaluate this relationship by conducting this systemic review and meta‐analysis. We performed a comprehensive systematic search of health science databases, including PubMed, Embase, Cochrane Library, Web of Science, MEDLINE, and ScienceDirect, to identify all relevant literature from their inception to March 1, 2023. We identified nine related articles, which were eventually included in this study. Our study showed no association between Lp(a) with new‐onset AF (HR = 1.45, 95% confidence interval [CI]: 0.57–3.67, p = .432). In addition, genetically elevated Lp(a) was not associated with the risk of atrial fibrillation (OR = 1.00, 95% CI: 1.00–1.00, p = .461). Different stratification of Lp(a) levels may have different outcomes. Also, higher Lp(a) levels may be inversely associated with the risk of developing AF compared to those with lower levels. Lp(a) levels were not associated with incident AF. Further research is needed to identify the mechanism underlying these results and better understand Lp(a) stratification for AF and the possible inverse association between Lp(a) and AF.
Tonotopic distribution and inferior colliculus projection pattern of inhibitory and excitatory cell types in the lateral superior olive of mice
Authors: Haragopal Hariprakash , Mellott Jeffrey G. , Dhar Matasha , Kanel Alinea , Mafi Amir , Tokar Nick , Winters Bradley D. 
Published: July 2023

AbstractThe principal neurons (PNs) of the lateral superior olive nucleus (LSO) are an important component of mammalian brainstem circuits that compare activity between the two ears and extract intensity and timing differences used for sound localization. There are two LSO PN transmitter types, glycinergic and glutamatergic, which also have different ascending projection patterns to the inferior colliculus (IC). Glycinergic LSO PNs project ipsilaterally while glutamatergic one's projections vary in laterality by species. In animals with good low‐frequency hearing (<3 kHz) such as cats and gerbils, glutamatergic LSO PNs have both ipsilateral and contralateral projections; however, rats that lack this ability only have the contralateral pathway. Additionally, in gerbils, the glutamatergic ipsilateral projecting LSO PNs are biased to the low‐frequency limb of the LSO suggesting this pathway may be an adaptation for low‐frequency hearing. To further test this premise, we examined the distribution and IC projection pattern of LSO PNs in another high‐frequency specialized species using mice by combining in situ hybridization and retrograde tracer injections. We observed no overlap between glycinergic and glutamatergic LSO PNs confirming they are distinct cell populations in mice as well. We found that mice also lack the ipsilateral glutamatergic projection from LSO to IC and that their LSO PN types do not exhibit pronounced tonotopic biases. These data provide insights into the cellular organization of the superior olivary complex and its output to higher processing centers that may underlie functional segregation of information.
On the evolution of polysensory superior temporal sulcus and middle temporal gyrus: A key component of the semantic system in the human brain
Authors: Petrides Michael 
Published: July 2023

AbstractThe primary auditory cortex and other early auditory cortical areas lie on Heschl's gyrus within the Sylvian fissure. On the adjacent lateral surface of the superior temporal gyrus, the cortex processes higher order auditory information leading to auditory perception. On the ventral surface of the temporal lobe in the primate brain, there are areas that process higher order visual information leading to visual perception. These sensory‐specific auditory and visual processing regions are separated by areas that integrate multisensory information within the deep superior temporal sulcus in both the macaque monkey and human brains. In the human brain, the multisensory integration cortex expands and forms the adjacent middle temporal gyrus. The expansion of this multisensory region in the language‐dominant hemisphere of the human brain is critical for the emergence of semantic processing, namely, the processing of conceptual information that is not sensory specific but rather relies on multisensory integration.
A rare case of prostate cancer initially presented by disseminated intravascular coagulation‐related subdural hemorrhage
Authors: Shafie Mahan , Shahmohamadi Elnaz , Hadizadeh Alireza , Hasanzadeh Alireza , Gholampour Golsa , Parsa Samaneh 
Published: July 2023

AbstractBackgroundDisseminated intravascular coagulation (DIC) has been reported in various solid malignancies and is a common coagulation‐related complication in prostate cancer. However, DIC has been rarely reported as the initial presentation of prostate cancer. Herein, we reported a patient referring with subdural hemorrhage (SDH) and DIC with an unexplained cause who was later diagnosed with prostate cancer.Case PresentationWe presented a 68‐year‐old man who was referred to the hospital with a gradual deterioration of consciousness, dyspnea, and edema in the genitalia and lower limbs. His primary laboratory tests showed elevated prothrombin time (PT) and partial thromboplastin time (PTT) and a decreased fibrinogen level of 47 mg/dL [200–400 mg/dL]. The DIC score was 7, which was suggestive of DIC. Moreover, cranial imaging showed SDH. Further work‐up revealed elevated prostate‐specific antigen and prostate enlargement with a mass effect on the bladder with a bone lesion, which was suggestive of metastatic prostate cancer.ConclusionThis report highlights DIC as a possible initial presentation of an underlying malignancy, as well as the importance of treatment of underlying disease in the management of DIC. A comprehensive and systematic work‐up is essential for early diagnosis in patients with DIC to avoid further complications and mortality.
Does Chiral Sensitivity of a Structure Depend on the Metal Core? Alkali Ion Complexes of Cyclo(Tyr‐Tyr)
Authors: Yoshizawa Koki , Hirata Keisuke , Ishiuchi Shun‐ichi , Fujii Masaaki , Zehnacker Anne 
Published: July 2023

AbstractAlkali metal complexes of cyclic dipeptide cyclo Tyr‐Tyr have been studied under cryogenic ion trap conditions. Their structure was obtained by combining Infra‐Red Photo‐Dissociation (IRPD) and quantum chemical calculations. The structural motif strongly depends on the relative chirality of the tyrosine residues. For residues of identical chirality, the cation interacts with one amide oxygen and one of the aromatic rings only; the distance between the aromatic rings does not change with the nature of the metal. In contrast, for residues of opposite chirality, the metal cation is located in between the two aromatic rings and interacts with both of them. The distance between the two aromatic rings strongly depends on the metal. Electronic spectra obtained by Ultra Violet Photodissociation (UVPD) spectroscopy and analysis of the UV photo‐fragments shed light on the excited state deactivation processes, which depend on both the chirality of the residue and that of the metal ion core. Na+ stands out by the presence of low‐lying charge transfer states resulting in the broadening of the electronic spectrum.
Heterogeneous Photocatalysts for Light‐Mediated Reversible Deactivation Radical Polymerization
Authors: Freeburne Sarah , Hunter Brock , Bell Kirsten , Pester Christian W. 
Published: July 2023

AbstractHeterogeneous photocatalysis combines the benefits of light‐mediated chemistry with that of a catalytic platform that facilitates re‐use of (often expensive) photocatalysts. This provides significant opportunities towards more economical, sustainable, safe, and user‐friendly chemical syntheses of both small and macromolecular compounds. This contribution outlines recent developments in the design of heterogenous photocatalysts and their use to mediate polymerizations. We outline four classes of heterogeneous photocatalysts in detail: Nanoparticles, conjugated and non‐conjugated polymer networks, metal‐organic frameworks (MOFs), and functionalized solid supports.
“Win‐Win” Modification of LiCoO2 Enables Stable and Long‐Life Cycling of Sulfide‐Based All Solid‐State Batteries
Authors: Lu Guozhong , Jiang Ying , Wu Xiang , Geng Fushan , Li Chao , Hu Bingwen , Shen Ming 
Published: July 2023

AbstractInterfacial side reactions and space charge layers between the oxide cathode material and the sulfide solid‐state electrolytes (SSEs), along with the structural degradation of the active material, significantly compromise the electrochemical performance of all‐solid‐state batteries (ASSLBs). Surface coating and bulk doping of the cathodes are considered the most effective approaches to mitigate the interface issues between the cathode and SSEs and enhance the structural integrity of composite cathodes. Here, a one‐step low‐cost means is ingeniously designed to modify LiCoO2 (LCO) with heterogeneous Li2TiO3/Li(TiMg)1/2O2 surface coating and bulk gradient Mg doping. When applied in Li10GeP2S12‐based ASSLBs, the Li2TiO3 and Li(TiMg)1/2O2 coating layers effectively suppress interfacial side reactions and weaken space charge layer effect. Furthermore, gradient Mg doping stabilizes the bulk structure to mitigate the formation of spinel‐like phases during local overcharging caused by solid‐solid contact. The modified LCO cathodes exhibit excellent cycle performance with a capacity retention of 80 % after 870 cycles. This dual‐functional strategy provides the possibility for large‐scale commercial implementation of cathodes modification in sulfide based ASSLBs in the future.
Study on the Construction of Interlayer Adjustable C@MoS2 Fiber Anode by Biomass Confining and its Lithium/Sodium Storage Mechanism
Authors: Liu Yingqi , Yuan Yifan , Peng Liangkui , Cheng Lu , An Bohua , Wang Ying , Wei Qufu , Xia Xin , Zhou Huimin 
Published: July 2023

AbstractBuilding a stable and controllable interlayer structure is the key to improving the sodium storage cycling stability and rate performance of two‐dimensional anode materials. This study explored the rich functional groups in bacterial cellulose culture medium in the way of biological self‐assembly. Mo precursors were used to produce chemical bond in bacterial cellulose culture medium, and intercalation groups are introduced to achieve MoS2 localized nucleation and in situ localized construction of carbon intercalation stable interlaminar structure, thus improving ion transport dynamics and cycle stability. In order to avoid structural irreversibility of MoS2 at low potential, an extended voltage window of 1.5–4 V was selected for lithium/sodium intercalation testing. It was found that there was a significant improvement in sodium storage capacity and stability. During the electrochemical cycling process, in‐situ Raman testing revealed that the structure of MoS2 was completely reversible, and the intensity changes of MoS2 characteristic peaks showed in‐plane vibration without involving interlayer bonding fracture. Moreover, after the lithium sodium was removed from the intercalation C@MoS2 all structures have good retention.
Modulating Electron Density of Ni‐N‐C Sites by N‐doped Ni for Industrial‐level CO2 Electroreduction in Acidic Media
Authors: Zhang Jiaji , Lin Gaobo , Zhu Jie , Wang Sifan , Zhou Wenhua , Lv Xiangzhou , Li Bolong , Wang Jianghao , Lu Xiuyang , Fu Jie 
Published: July 2023

AbstractElectro‐chemically reducing CO2 in a highly acidic medium is promising for addressing the issue of carbonate accumulation. However, the hydrogen evolution reaction (HER) typically dominates the acidic CO2 reduction. Herein, we construct an efficient electro‐catalyst for CO formation based on a core‐shell structure, where nitrogen‐doped Ni nanoparticles coexist with nitrogen‐coordinated Ni single atoms. The optimal catalyst demonstrates a significantly improved CO faradaic efficiency (FE) of 96.7 % in the acidic electrolyte (pH=1) at an industrial‐scale current density of 500 mA cm−2. Notably, the optimal catalyst maintains a high FE of CO exceeding 90 % (current density=500 mA cm−2) in the electrolyte with a wide pH range from 0.67 to 14. In‐situ spectroscopic characterization and density functional theory calculations show that the local electron density of Ni‐N‐C sites is enhanced by N‐doped Ni particles, which facilitates the formation of *COOH intermediate and the adsorption of *CO. This study demonstrates the potential of a hybrid metal/Ni‐N‐C interface in boosting acidic CO2 electro‐reduction.
Efficient One‐Pot Synthesis of 2,5‐Furandicarboxylic Acid from Sugars over Polyoxometalate/Metal‐Organic Framework Catalysts
Authors: Zeng Di , Wang Wenjing , Zhang Yu , Wang Juxue , Cui Bingkun , Jia Taikang , Li Ruofan , Chu Hongxiang , Zhang Ling , Wang Wenzhong 
Published: July 2023

AbstractConverting extensive sugars into value‐added 2,5‐furandicarboxylic acid (FDCA) has been considered to be a promising approach to developing sustainable substitutes for chemicals from fossil resources. The complicated conversion processes involved multiple cascade reactions and intermediates, which made the design of efficient multifunction catalysts challenging. Herein, we developed a catalyst by introducing phosphotungstic acid (PW) and Co sites into the UiO‐66, which achieved a one‐pot cascade conversion of fructose‐to‐FDCA with high conversion (>99 %) and yield (94.6 %) based on the controllable Lewis/Brønsted acid sites and redox sites. Controlled experiments and detailed characterizations show that the multifunctional PW/UiO(Zr, Co) catalysts successfully affords the direct synthesis of FDCA from fructose via dehydration and selective oxidation in the one‐pot reaction. Additionally, the MOF catalysts could also efficiently convert various sugars into FDCA, which has broad application prospects. This study provides new strategies for designing multifunctional catalysts to achieve efficient production of FDCA from biomass in the one‐pot reaction.
Role of scrape cytology smear preparation in the diagnosis of ovarian masses‐utility and pitfalls
Authors: Agarwal Shikha , Bohara Sangita , Luthra Sonia 
Published: July 2023

AbstractBackgroundScrape cytology technique is useful for rapid intraoperative diagnosis of ovarian mass lesions that acts as an adjunct to frozen section examination. Though ovaries can be accessed by laparoscopy and USG guided FNAC, there are controversial reports regarding the safety of these procedures. The present study has been designed to evaluate the role of scrape cytology in a variety of ovarian mass lesions.ObjectivesTo study the cyto‐morphology of ovarian mass lesions and to evaluate the role of scrape cytology technique in correctly diagnosing the ovarian lesions taking histopathological diagnosis as gold standard.Material and MethodsThis is a prospective observational study done on 61 ovarian mass lesions as received from the Obstetrics and Gynecology department of our Institution.ResultOut of 61 cases, 58 (95.08%) cases were correctly diagnosed with respect to categorization and typing. The age ranged from 14 to 65 years with the mean age being 38.1 years. On histopathology, out of 61 cases, 39 (63.93%) were epithelial along with sub categorization of benign, borderline, and malignant, 13 (22.9%) were germ cell tumors, 5(8.19%) were sex cord stromal tumors, 3 (4.91%) were hemorrhagic cysts and the remaining 1 (1.63%) was massive ovarian edema. Thus, on comparing with histopathology, the sensitivity and specificity of scrape cytology technique were 93.55% and 96.67%, and the diagnostic accuracy was 95.08%.ConclusionScrape cytology of ovarian lesions can give quick and reliable results. Also, proper training of cytopathologists chiefly regarding the sampling technique, gross presentation of ovarian lesions and interpretation of scrape cytology smears is needed. Further studies to provide standard guidelines and reporting criteria will prove to be helpful.