bluuebunny/crossref_metadata_2025_split huggingface dataset:
Buddhism and M&A performance: Evidence from China
Authors: Shi Wen , Bi Xiaogang 
Published: May 2023

AbstractThis research explores the effect of Buddhism on mergers & acquisitions (M&As) performance, using 4622 M&A transactions of Chinese public firms from 2004 to 2018. Herein, we offer sufficient evidence that the acquirers located in higher Buddhism intensity regions performed better for both short‐ and long‐term after merger. Furthermore, we show that state ownership also plays an essential role in mitigating its effect, whilst our channel analysis indicates that the source of value creation is driven by higher deal completion rates and fewer violation cases for acquiring firms. Finally, we address the endogeneity issue, and the results remain unaffected.
Free power, irrigation, and groundwater depletion: Impact of farm electricity policy of Punjab, India
Authors: Gupta Disha 
Published: May 2023

AbstractThis paper examines the impact of a change in the policy regime from flat rate to free farm electricity pricing, introduced in Punjab, India in February 1997 using a difference‐in‐differences framework. Based on village‐level data from the second and the third rounds of the Minor Irrigation Census, the study finds a differential increase in the number of electric‐operated tubewells and horsepower load of pumps in Punjab as compared to an agriculturally‐similar and neighboring state, Haryana, which is taken as the control group. Through these channels, the study finds that the average groundwater depth increased by 1.9 meters more in Punjab as compared to Haryana, which is 22 percent of the baseline average groundwater depth in Punjab. Nationally‐representative well‐level data on groundwater depths from the Central Ground Water Board shows impact heterogeneity with sharper effect on groundwater depth for wells that are lying closer to the cut‐off of about 10 meters where a technological shift from centrifugal to submersible pumps is required to maintain access to groundwater pumping.
Identification of follicle‐stimulating hormone‐responsive genes in Sertoli cells during early postnatal mouse testis development
Authors: Wang Huizhen , Liu Zhenghui , Larsen Mark , Hastings Richard , Gunewardena Sumedha , Kumar T. Rajendra 
Published: May 2023

AbstractBackgroundIn the mouse testis, Sertoli cells rapidly divide during a narrow window of time pre‐pubertally and differentiate thereafter. The number of Sertoli cells determines the testis size and germ cell‐carrying capacity. Follicle‐stimulating hormone (FSH) binds its cognate FSH‐receptors expressed on Sertoli cells and acts as a mitogen to regulate their proliferation. Fshb−/− mutant adult male mice have reduced Sertoli cell number and testis size and reduced sperm number and motility. However, FSH‐responsive genes in early postnatal mouse Sertoli cells are unknown.ObjectivesTo identify FSH‐responsive genes in early postnatal mouse Sertoli cells.Materials and methodsA fluorescence‐activated cell sorting method was developed to rapidly purify Sertoli cells from control and Fshb−/− mice carrying a Sox9 GfpKI allele. These pure Sertoli cells were used for large‐scale gene expression analyses.ResultsWe show that mouse Sertoli cells rarely divide beyond postnatal day 7. Our in vivo BrdU labeling studies indicate loss of FSH results in a 30% reduction in Sertoli cell proliferation in mice at 5 days of age. Flowsorted GFP+ Sertoli cells with maximal Fshr expression were 97%‐98% pure and mostly devoid of Leydig and germ cells as assessed by Taqman qPCR quantification of gene expression and immunolabeling of the corresponding cell‐specific markers. Large‐scale gene expression analysis identified several differentially regulated genes in flow‐sorted GFP+ Sertoli cells obtained from testis of control and Fshb−/− mice at 5 days of age. The top 25 networks identified by pathway analysis include those related to the cell cycle, cell survival and most importantly, carbohydrate and lipid metabolism and molecular transport.DiscussionSeveral of the FSH‐responsive genes identified in this study could serve as useful markers for Sertoli cell proliferation in normal physiology, toxicant‐induced Sertoli cell/testis injury, and other pathological conditions.ConclusionOur studies reveal that FSH‐regulates macromolecular metabolism and molecular transport networks of genes in early postnatal Sertoli cells most likely in preparation for establishment of functional associations with germ cells to successfully coordinate spermatogenesis.
Potentially avoidable mortality after endoscopic retrograde cholangiopancreatography in Australia: an 8‐year qualitative analysis
Authors: Jolly Samantha , Chu Matthew K. W. , Gupta Aashray K. , Mitchell Jessica , Kovoor Joshua G. , Stewart Sasha K. , Babidge Wendy J. , Chan Justin C. Y. , Trochsler Markus I. , Maddern Guy J. 
Published: May 2023

AbstractBackgroundEndoscopic retrograde cholangiopancreatography (ERCP) is a commonly performed procedure worldwide. The aim of this study was to examine cases of mortality after ERCP to identify clinical incidents that are potentially preventable, to improve patient safety.MethodsThe Australian and New Zealand Audit of Surgical Mortality provides an independent and externally peer‐reviewed audit of surgical mortality pertaining to potentially avoidable issues. A retrospective review of prospectively collected data within this database was performed for the 8‐year audit period from 1 January 2009 to 31 December 2016. Clinical incidents were identified by assessors through first‐ or second‐line review, and thematically coded into periprocedural stages. These themes were then qualitatively analysed.ResultsThere were 58 potentially avoidable deaths following ERCP, with 85 clinical incidents. Preprocedural incidents were most common (n = 37), followed by postprocedural (n = 32) and then intraprocedural (n = 8). Communication issues occurred across the periprocedural period (n = 8). Preprocedural incidents included delay to procedure, inadequate resuscitative management, decision to perform procedure and inadequate assessment. Intraprocedural incidents comprised technical factors and inadequate support. Postprocedural incidents involved inappropriate treatment, delay in definitive surgical treatment or in recognizing complications, inappropriate second‐line intervention and inadequate assessment. Communication incidents comprised inadequate documentation, failure to escalate care and poor inter‐clinician communication.ConclusionCauses of mortality following ERCP are wide‐ranging, and reviewing clinical incidents associated with potentially avoidable mortality can serve to inform and educate practitioners. In collating a subset of cases in which procedure‐related mortality was deemed avoidable, a series of cautionary tales about ERCP is presented that may provide cues to practitioners on improving patient safety and inform future surgical practice.
Can sarcopenia predict survival in locally advanced rectal cancer patients?
Authors: Gartrell Richard , Qiao Jing , Kiss Nicole , Faragher Ian , Chan Steven , Baird Paul N. , Yeung Justin M. 
Published: May 2023

AbstractBackgroundThere is mounting evidence that suggests sarcopenia can be used to predict survival outcomes in patients with colon cancer. However, the effect on locally advanced rectal cancer (LARC) is less clear. We sought to determine the association between sarcopenia on Overall Survival and Recurrence‐free Survival (OS and RFS) in patients with LARC undergoing multimodal treatment.MethodsA retrospective study was undertaken of all pre‐treatment stage 2–3 rectal cancer patients who underwent neo‐adjuvant treatment and surgery with curative intent between January 2010 and September 2016 at Western Health. Sarcopenia was measured on pre‐treatment staging scans at the third lumbar vertebrae and defined using cohort‐derived, sex‐specific thresholds. Primary outcomes were OS and RFS.ResultsA total of 132 patients with LARC were analysed. Sarcopenia: Hazard ratio (HR) 3.71; 95% CI, 1.28–10.75, P = 0.016 was independently associated with worse Overall Survival following multivariate analysis. There was no significant relationship between sarcopenia and RFS: Time ratio (TR) 1.67; 95% CI 0.52–5.34, P = 0.386.ConclusionSarcopenia was found to be an independent risk factor for worse overall survival, but not recurrence free survival, in patients with locally advanced rectal cancer undergoing neo‐adjuvant chemo‐radiotherapy and surgery with curative intent.
Reviewing the risk of breast cancer recurrence following breast reconstruction
Authors: Huang Yang Yang , Sacks Brett , Fahey Michael T. , Farrell Gillian , Poliness Catherine , Webb Angela 
Published: May 2023

AbstractBackgroundIt is widely accepted that both autologous and alloplastic reconstruction are safe. A recent publication reported a significant association between textured implants and metastatic recurrence of breast cancer. This study aims to assess if the published results are reproducible in our cohort and to review the safety of breast reconstruction.MethodsThis is a retrospective cohort study of adult patients undergoing mastectomy and either alloplastic or autologous breast reconstruction at a single quaternary hospital. Outcomes include disease free survival (DFS), local and recurrence free survival (LRRFS) and BIA‐ALCL. For time to event endpoints, unadjusted and multivariate adjusted hazard ratios (HRs) were estimated using Cox regression, and penalized Cox regression respectively.ResultsFour hundred and twenty‐six patients of whom 187 underwent autologous reconstruction and 239 underwent alloplastic. There were 43 cancer recurrences (24 alloplastic and 19 autologous) and 14 local regional recurrences (8 alloplastic and 4 autologous). There were 26 deaths and no instances of BIA‐ALCL. Median follow‐up time was 4.7 years. No evidence of association was found between breast reconstruction method and DFS (HR 0.87 CI: 0.47–1.58). It is uncertain whether implant texture grade was associated with increased breast cancer recurrence (HR 2.17 CI: 0.65–7.52).ConclusionBoth autologous and alloplastic breast reconstruction have been carried out in our cohort and reconstructive modality was not associated with either reduced DFS or LRRFS. The results in this cohort show there is uncertainty between the use of textured breast implants and either local or distant breast cancer recurrence.
Automatic estimation of the cross‐sectional area of the waist of the nerve fibre layer at the optic nerve head
Authors: Kisonaite Konstancija , Yu Zhaohua , Raeme Faisal , Bendazzoli Simone , Wang Chunliang , Söderberg Per G. 
Published: May 2023

AbstractPurposeGlaucoma leads to pathological loss of axons in the retinal nerve fibre layer at the optic nerve head (ONH). This study aimed to develop a strategy for the estimation of the cross‐sectional area of the axons in the ONH. Furthermore, improving the estimation of the thickness of the nerve fibre layer, as compared to a method previously published by us.MethodsIn the 3D‐OCT image of the ONH, the central limit of the pigment epithelium and the inner limit of the retina, respectively, were identified with deep learning algorithms. The minimal distance was estimated at equidistant angles around the circumference of the ONH. The cross‐sectional area was estimated by the computational algorithm. The computational algorithm was applied on 16 non‐glaucomatous subjects.ResultsThe mean cross‐sectional area of the waist of the nerve fibre layer in the ONH was 1.97 ± 0.19 mm2. The mean difference in minimal thickness of the waist of the nerve fibre layer between our previous and the current strategies was estimated as CIμ (0.95) 0 ± 1 μm (d.f. = 15).ConclusionsThe developed algorithm demonstrated an undulating cross‐sectional area of the nerve fibre layer at the ONH. Compared to studies using radial scans, our algorithm resulted in slightly higher values for cross‐sectional area, taking the undulations of the nerve fibre layer at the ONH into account. The new algorithm for estimation of the thickness of the waist of the nerve fibre layer in the ONH yielded estimates of the same order as our previous algorithm.
Seasonal shifts in large mammal activity relative to fruit availability and hunting risk along a protected area boundary in Borneo
Authors: Cosby Olivia G. , Giman Belden , Ragai Roslina , Bodos Vilma , Van Deelen Timothy R. , McShea William J. 
Published: May 2023

AbstractUnderstanding wildlife spatiotemporal dynamics at protected area boundaries is critical to conservation. In SE Asia, protected areas are often bordered by indigenous communities whose traditional practices result in increased landscape heterogeneity within their community managed forests (CF). Because SE Asian forests exhibit supra‐annual mast fruiting (3–7 yrs) and sustained fruit scarcity, wildlife using CF may benefit from greater availability of fruits and seeds encouraged by traditional management, but incur greater risk of being hunted. We examined shifts in wildlife activity in forests within and adjacent to Lanjak Entimau Wildlife Sanctuary (LEWS), in Sarawak, Malaysia. Using camera traps and surveys of fruiting phenology, we related presence of fruits and seeds to shifts in large mammal activity over 3 years (October 2016–2019). We first compared relative frequency of five focal species (sun bear, bearded pig, muntjac, mouse deer, and sambar) by forest type for a given survey year and season (rainy vs. dry). We then modeled activity to assess how fruit availability, landscape features, and proxies for hunting risk, influence seasonal shifts in habitat use. Our results suggested seasonal variation in concert with increased landscape heterogeneity influenced patterns of activity. We found no evidence that CF excluded any detected mammal species, suggesting CF contribute important habitat to wildlife, particularly during periods of fruit scarcity in primary forest. However, our findings also imply increased hunting risk for wildlife attracted to resources near human settlements, emphasizing the need to consider the influence of both annual and supra‐annual seasonality when developing best practices for the sustainable management.
When partitioning is not an option: Resource availability predicts intraguild interactions in two isolated Amazonian primate assemblages
Authors: Cavalcante Thiago , Mourthé Ítalo , Barnett Adrian A. , Bicca‐Marques Júlio César 
Published: May 2023

AbstractAssemblage structure and acquisition of high‐value resources will usually be affected by changes in resource availability and differential competitive abilities of assemblage members. In fragmented habitats where carrying capacity limits are exceeded due to high population densities and biomass, interspecific interactions can be expected to occur at a high frequency, potentially turning into an important cost for coexistence. We studied assemblage‐ and guild‐level patterns of interspecific interactions in two highly diverse isolated primate assemblages in southern Amazonia. Specifically, we assessed the effects of temporal variation in fruit availability on the rates of interspecific interactions between gray woolly monkeys (Lagothrix lagotricha cana), one of the largest tree‐dwelling mammals of the Amazon forests, and nine syntopic primate species. We found that fruit availability positively predicted rate of intraguild interactions in contrast to overall assemblage interaction rate. We did not find statistical evidence for the effect of fruit availability on the assemblage rates of type‐dependent (i.e., agonistic or non‐agonistic) and context‐dependent (i.e., feeding or non‐feeding) interactions. However, there was a clear trend toward increased feeding‐related and agonistic‐related interactions as fruit availability increased, with agonistic interactions mostly occurring at guild‐level. These results provide support for a significant role of fruit availability in structuring spatial–temporal intraguild interactions at our study sites. Costly interspecific interactions and spatial habitat overlap can be expected to occur at a high frequency in highly diverse assemblages living in human‐modified landscapes, which in turn, can have potentially negative impacts to the species involved.
Assessment for the timing of comprehensive genomic profiling tests in patients with advanced solid cancers
Authors: Hagio Kanako , Kikuchi Junko , Takada Kohichi , Tanabe Hiroki , Sugiyama Minako , Ohhara Yoshihito , Amano Toraji , Yuki Satoshi , Komatsu Yoshito , Osawa Takahiro , Hatanaka Kanako C. , Hatanaka Yutaka , Mitamura Takashi , Yabe Ichiro , Matsuno Yoshihiro , Manabe Atsushi , Sakurai Akihiro , Ishiguro Atsushi , Takahashi Masato , Yokouchi Hiroshi , Naruse Hirohito , Mizukami Yusuke , Dosaka‐Akita Hirotoshi , Kinoshita Ichiro 
Published: May 2023

AbstractComprehensive genomic profiling (CGP) tests have been covered by public insurance in Japan for patients with advanced solid tumors who have completed or are completing standard treatments or do not have them. Therefore, genotype‐matched drug candidates are often unapproved or off‐label, and improving clinical trial access is critical, involving the appropriate timing of CGP tests. To address this issue, we analyzed the previous treatment data for 441 patients from an observational study on CGP tests discussed by the expert panel at Hokkaido University Hospital between August 2019 and May 2021. The median number of previous treatment lines was two; three or more lines accounted for 49%. Information on genotype‐matched therapies was provided to 277 (63%). Genotype‐matched clinical trials were ineligible because of an excess number of previous treatment lines or use of specific agents were found in 66 (15%) patients, with the highest proportion in breast and prostate cancers. Many patients met the exclusion criteria of one to two or more treatment lines across cancer types. In addition, previous use of specific agents was a frequent exclusion criterion for breast, prostate, colorectal, and ovarian cancers. The patients with tumor types with a low median number (two or fewer) of previous treatment lines, including most rare cancers, primary unknown cancers, and pancreatic cancers, had significantly fewer ineligible clinical trials. The earlier timing of CGP tests may improve access to genotype‐matched clinical trials, with their proportion varying by cancer type. Each relevant society needs to advocate the desirable timing of CGP testing nationwide.
Child of two worlds: How foster care workers perceive their skills in dealing with worldview differences in foster care
Authors: van de Koot‐Dees Danielle , Noordegraaf Martine , Reitsma Bernhard 
Published: May 2023

AbstractFoster children often encounter worldview differences between their foster family and their birth family, for example, when participating in religious activities and practices. Foster children not only have a right to continuity in upbringing but also consistency in worldview, culture and language. Good co‐parenting relationships are important for their identity development. For these reasons, foster care workers are entrusted with the task of supporting the triadic relationship of the foster child, birth parents and foster parents in dealing with worldview differences. Based on in‐depth interviews with foster care workers (n = 16) six skills in dealing with worldview differences can be distinguished: (1) basic knowledge of worldviews and identity formation; (2) empathizing with the other; (3) inquisitiveness to discover what is essential for the other; (4) initiating worldview conversations and keeping them going; (5) fostering self‐reflection in worldview; and (6) manoeuvring between and monitoring all interests. It is helpful if birth parents are well‐informed in advance about the impact of worldview differences and if foster care workers and foster parents are aware of the identity and developmental needs of foster children to explore the worldview of the foster family and the birth family.
Morphological and genetic causes of fetal cardiomyopathies
Authors: Kohaut Eva , Ader Flavie , Rooryck Caroline , Pelluard Fanny , Bonnière Maryse , André Gwenaelle , Sauvestre Fanny , Roth Philippe , Khraiche Diala , Bessières Bettina , Attié‐Bitach Tania , Richard Pascale 
Published: May 2023

AbstractCardiomyopathies are diseases of the heart muscle with variable clinical expressivity. Most of forms are inherited as dominant trait, and with incomplete penetrance until adulthood. Severe forms of cardiomyopathies were observed during the antenatal period with a pejorative issue leading to fetal death or medical interruption of pregnancy. Variable phenotypes and genetic heterogeneity make etiologic diagnosis difficult. We report 11 families (16 cases) whose unborn, newborn or infant with early onset cardiomyopathies. Detailed morphological and histological examinations of hearts were implemented, as well as genetic analysis on a cardiac targeted NGS panel. This strategy allowed the identification of the genetic cause of the cardiomyopathy in 8/11 families. Compound heterozygous mutations in dominant adulthood cardiomyopathy genes were found in two, pathogenic variants in co‐dominant genes in one, de novo mutations in 5 including a germline mosaicism in one family. Parental testing was systematically performed to detect mutation carriers, and to manage cardiological surveillance and propose a genetic counseling. This study highlights the great diagnostic value of the genetic testing of severe antenatal cardiomyopathy both for genetic counseling and to detect presymptomatic parents at higher risk of developing cardiomyopathy.
Molecular phylogeny, divergence time, biogeography and trends in host plant usage in the agriculturally important tortricid tribe Grapholitini (Lepidoptera: Tortricidae: Olethreutinae)
Authors: Hu Gui‐Lin , Brown John , Heikkilä Maria , Aarvik Leif , Mutanen Marko 
Published: May 2023

AbstractThe leaf‐roller moth tribe Grapholitini comprises about 1200 described species and contains numerous notorious pests of fruits and seeds. The phylogeny of the tribe has been little studied using contemporary methods, and the monophyly of several genera remains questionable. In order to provide a more robust phylogenetic framework for the group, we conducted a multiple‐gene phylogenetic analysis of 104 species representing 27 genera of Grapholitini and 29 outgroup species. Divergence time, ancestral area, and host plant usage were also inferred to explore evolutionary trends in the tribe. Our analyses indicate that Larisa and Corticivora, traditionally assigned to Grapholitini, are best excluded from the tribe. After removal of these two genera, the tribe is found to be monophyletic, represented by two major lineages—a Dichrorampha clade and a Cydia clade, the latter of which can be divided into seven generic groups. The genus Grapholita was found to be polyphyletic, comprising three different clades, and we propose three genera to accommodate these groups: Grapholita (sensu stricto), Aspila (formerly a subgenus of Grapholita) and Ephippiphora (formerly considered a synonym of Grapholita). We summarize each generic group, including related genera not included in our analysis, providing morphological, pheromone and food plant characters that support particular branches within the molecular hypotheses. Biogeographical analyses indicate that Grapholitini probably originated in the Nearctic, Afrotropical and Neotropical regions in the Lutetian of the middle Eocene (ca. 44.3 Ma). Our results also indicate that most groups in Grapholitini originated from Fabaceae‐feeding monophagous or oligophagous ancestors, and that host plant shifts probably promoted species diversification within the tribe.