bluuebunny/crossref_metadata_2025_split huggingface dataset:
Holistic Approach to Improve Quality of Life in Head-and-Neck Cancer Patients Using CARER Model of Supportive Care
Authors: Mahindra Samara , George Paul , Rao Vishal 
Published: February 2023

Aim:
To describe a model (CARER) of supportive care for head-and-neck cancer (HNC) patients and survivors.

Methods:
Primary data were collected from HNC patients from November 2018 to February 2019. An intervention-based CARER protocol was prescribed to 25 HNC patients. Data on movement and meditation, emotional status, spiritual and mental well-being were assessed in patients at baseline and end line (6 weeks). CARER assessed the patients and caregiver's satisfaction through a questionnaire rating on a scale of 1 to 5 (1-worst and 5-best). Student's independent t-test was used to assess differences between various scores at different time points, and P < 0.05 was considered statistically significant.

Results:
All patients received the CARER 45 program (mean age 56.0 ± 14.0 years) with 100% compliance. When compared to baseline, onco-nutrition score improved significantly at the end line (5.5 vs. 8.7, P < 0.05). Similarly, significant improvement was observed in onco-movement and meditation (5.9 vs. 6.9, P < 0.05) and onco-mental well-being scores (6.2 vs. 7.5, P < 0.05).

Conclusion:
Our study supports the utilization of holistic care using CARER model for patients living with and beyond cancer. Furthermore, this study offers potential support for further research on CARER model to influence future policy and funding decisions.
Expression of Breast Cancer Gene 2 in Oral Squamous Cell Carcinoma and its Correlation with the Metastatic Potential
Authors: Mistry Niharika Hitendra , Gosavi Suchitra Rajesh , Dhobley Akshay , Mishra Shubhangi , Kherde Pooja 
Published: February 2023

Background:
Breast cancer gene 2 (BRCA2), a tumor suppressor gene, has been extensively evaluated in various cancers and correlated with metastatic potentials. However, to the best of our knowledge, the correlation has not been reflected in the literature in patients with oral squamous cell carcinoma (OSCC). Any positive correlation may yield the protein as an exploitable marker for the prediction of metastasis and target for chemotherapy in patients with OSCC.

Materials and Methods:
This observational retrospective study was conducted on 54 tissue samples, 18 samples each of normal oral mucosa, and of OSCC with and without cervical lymph node metastasis. The study samples were immunohistochemically stained with BRCA2 antibody. The staining index was calculated as a product of the percentage of positive cells per high-power field (HPF) (A) and the staining intensity (B).

Results:
Based on intergroup comparisons, it was found that the percentage of positive cells/HPF, staining intensity, and staining index were higher in OSCCs with cervical lymph node metastasis and lower in normal oral mucosa samples. It was found that a large number of the normal oral mucosa samples (n = 13) did not show any BRCA2 immunoreactivity and a large number of the OSCC samples with cervical lymph node metastasis displayed high BRCA2 immunoreactivity (n = 15).

Conclusion:
Overexpression of BRCA2 is linked to the presence of metastases in patients with OSCC and has the potential to be utilised as a marker to predict the outcome of the patient's treatment. The findings may be used in the future to develop targeted therapies, depending on the direction that future research follows.
A Randomized Trial Comparing the Efficacy of Oral Preemptive Pregabalin and Gabapentin for Postoperative Analgesia
Authors: Prasad T. Krishna , Prabu Pavithra , Priyadharsini K. Soundarya 
Published: February 2023

Background:
Modern anesthesia practice utilizes preemptive analgesia for providing pain relief postoperatively using oral drugs such as pregabalin and gabapentin which are otherwise used for chronic pain management. We aimed to determine which among the two is more proficient.

Materials and Methods:
This randomized double-blinded control study was done among 72 subjects undergoing lower abdominal surgeries under the subarachnoid block and they were randomly divided into three groups: Group 1 received a single dose of tablet pregabalin 150 mg orally, Group 2 received tablet gabapentin 600 mg orally, and Group 3 received placebo drug orally (tablet B-complex) 2 h before subarachnoid block. Pain scores, time of 1st rescue analgesic, total number of rescue analgesics, sedation score, and occurrence of side effects were also noted for 24 h. The data were analyzed using SPSS 16 with Chi-square/Fisher's exact test or analysis of variance/Kruskal–Wallis test. A statistically significant difference was considered when P < 0.05.

Results:
Pain scores were lesser in Group 1 and 2 except at 2nd h. Total rescue analgesic time among maximum subjects in Group 1 was 4 h 30 min, in Group 2 was 3 h 30 min and 4 h, whereas in Group 3 was 3 h (P < 0.001). The total dose of analgesics in the first 24 h was 2 doses in Group 1, 2 doses in Group 2, and 3 doses in Group 3 (P < 0.001). Sedation score was more on Group 1 and 2 in comparison to Group 3 with no side effects in all groups.

Conclusions:
We conclude that pregabalin to be the effective preemptive drug because of its lesser pain intensity scores and good sedation property.
Trends in the Incidence of Japanese Spotted Fever in Japan: A Nationwide, Two-Decade Observational Study from 2001–2020
Authors: Otsuka Yuki , Hagiya Hideharu , Fukushima Shinnosuke , Harada Ko , Koyama Toshihiro , Otsuka Fumio 
Published: February 2023

ABSTRACT.
The worldwide spread of tick-borne diseases (TBDs) has become a public health concern. Therefore, this study aimed to clarify trends in the incidence of Japanese spotted fever (JSF), one of Japan’s most prevalent TBDs. Weekly infectious disease reports were used to calculate the annual incidence rates (AIRs) of JSF. Data were stratified by age and sex, and joinpoint regression analysis was performed to estimate the annual percentage change (APC). AIR and APC were geographically compared among the 47 prefectures. A total of 3,453 JSF cases were observed from 2001 to 2020. The AIR per 100,000 population was 0.03 in 2001, which increased approximately 10-fold to 0.33 in 2020. The average APC (AAPC) during the study period was 12.3% (95% CI: 10.7–13.9). By age group, the incidence of JSF increased more rapidly among the older population: 11.5% (95% CI: 10.1–12.9) in those aged ≥ 65 years and 8.9% (95% CI: 6.4–11.5) in those aged < 50 years. Although the AIR over the past two decades was higher in climatically warm regions located in southwestern Japan and on the Pacific coast, increases in the AAPC were notable in colder regions located in eastern Japan. The incidence of JSF continues to increase in Japan, especially among older populations and in eastern prefectures, where the disease has not been previously diagnosed.
Analyzing Health of Forcibly Displaced Communities through an Integrated Ecological Lens
Authors: Tarnas Maia C. , Ching Carly , Lamb Joleah B. , Parker Daniel M. , Zaman Muhammad H. 
Published: February 2023

ABSTRACT.
Health care among forcibly displaced persons is frequently driven by siloed approaches. Aspects of the built environment, social factors, and the bidirectional relationship between the changing ecosystem and residents are often ignored in health policy design and implementation. While recognizing factors that create a preference for siloed approaches and appreciating the work of humanitarian agencies, we argue for a new data-driven and holistic approach to understand the health of the forcibly displaced. It should be rooted in the realities of the emergence of new diseases, dynamic demographics, and degrading environments around the displaced communities. Such an approach envisions refugee and internally displaced camps as dynamic, complex ecosystems that alter, and are altered by, spatial and temporal factors. At the root of this approach is the necessity to work across disciplines, to think holistically, to go beyond treating single ailments, and to develop ethical approaches that provide dignity to those who are forcibly displaced.
Lowry, Malcolm (1909–1957)
Authors: Cannon Nissa Ren 
Published: February 2023

Malcolm Lowry (1909–57) was a British-born writer, best remembered for his 1947 novel Under the Volcano. Born in England, Lowry spent much of his adulthood in Canada, and is sometimes classified as a Canadian author. His writing is highly autobiographical, and his posthumously published writing reveals a proclivity for incorporating text from his letters and diary entries into his fictionalised works. Characteristics of Lowry’s writing include non-linear chronology, an emphasis on memory, and an interest in the beauty of the natural world. Lowry envisioned nearly all of his works as connected to one another, part of a never-realised saga entitled The Voyage That Never Ends, which he modelled on Dante’s tripartite Divina Commedia.
Lowry published just two novels during his lifetime: the largely forgotten Ultramarine (1933), and the critically acclaimed Under the Volcano. In the words of Lowry scholar Sherrill Grace, ‘the Malcolm Lowry legend rests upon two foundations, Under the Volcano and alcohol’ (2009: xiii). Lowry’s reputation as a heavy drinker was established before he went to Cambridge University, and the ill-effects of his alcoholism included periods spent in various institutions and hospitals. Lowry died in Ripe, Sussex, England, on 27 June 1957. The coroner found alcohol and barbiturates in Lowry’s system, and ruled it a ‘death by misadventure’.
Le Concept de Sapientia à l'épreuve de l'écriture, ou quand la chronique devient espace de controverse
Authors: ESCURIGNAN Soizic 
Published: February 2023

Dès les années 350, des conflits ont émaillé les relations entre l’Église et le pouvoir laïque, et les pouvoirs temporel et spirituel sont alors entrés en concurrence. Les papes ont engagé un bras de fer avec les puissances temporelles afin de s’affranchir de leur tutelle politique. Surtout, l’Église romaine ne voulait pas d’un modèle césaropapiste à la byzantine où l’Église est subordonnée au pouvoir laïque. C’est dans ce contexte que prend place la célèbre lettre du pape Gélase Ier qui, en 494, affirmait à Anastase Ier que le monde est principalement gouverné par deux choses : l’autorité sacrée des évêques et le pouvoir royal.
The Clustering Tindak Kekerasan Dalam Rumah Tangga Di Kota Samarinda Menggunakan Algoritma K-Means
Authors: Stepanus Ginting Roni , Hamdani Hamdani , Septiariani Anindita , Alameka Faza 
Published: February 2023

Peran Kepolisian Resort Samarinda dalam membantu keamanan dan penegakan hukum sesuai dengan Pasal 5 Undang-Undang No. 23 Tahun 2004 dapat menggunakan data kdrt untuk clustering tingkat kdrt berdasarkan tinggi, sedang dan rendah. Clustering atau mengelompokkan data dapat dilakukan dengan menerapkan algoritma K-Means. Penerapan algoritma ini menggunakan 3 metode perhitungan jarak yaitu, Euclidean Distance, Minkowski Distance dan Manhattan Distance Dan hasil perhitungan algoritma kmeans dengan menggunakan Euclidean Distance Mendapatkan 2 Cluster di C1,9 cluster di C2 dan 1 cluster di C3,Selanjutnya menggunakan Manhattan Distance Dan hasil yang di dapat yaitu 3 Cluster di C1, 8 cluster di C2 dan 1 cluster di C3 dan yang terakhir Menggunakan , Minkowski Distance Distance Mendapatkan 2 Cluster di C1,9 cluster di C2 dan 1 cluster di C3. Penggunaan 3 metode ini dimaksudkan untuk mengetahui perhitungan jarak yang lebih ideal untuk digunakan. Selain menggunakan metode perhitungan jarak, digunakan juga metode pengukuran jarak yaitu SSE (Sum of Squared Errors) dan ketiga metode perhitungan tersebut mendapatkan hasil SSE (Sum of Squared Errors) nya sebagai berikut.Euclidean Distance=1,2535, Minkowski Distance=1,2418 dan Manhattan Distance=5,7154.
Основные направления социальной политики Узбекистана в контексте “Стратегии Действий”
Authors: Аминова Азиза 
Published: February 2023

В статье освещена политика государства, направленная на совершенствование социальной политики на основе «Стратегии действий», включающая внедрение новых механизмов взаимодействия административных органов с народом, усовершенствование деятельности социальных институтов, местных органов. Раскрыта роль государства в повышении материального благосостояния граждан республики, повышение заработной платы, совершенствование деятельности банков. Проанализированы программы, направленные на модернизацию жилищной сферы, посредством улучшения производственных и социальных инфраструктур городской и сельской местности. Освещены вопросы реформирования медицинского обслуживания, внедрение инновационных методов оказания услуг и производства медицинских препаратов, внедрение новых качественных методов борьбы с бедностью через повышение трудозанятости, развитие предпринимательства.
Сочинение «Фирдаус ал-икбал» и изучение периода правления Мухаммада Рахимхана I зарубежными востоковедами
Authors: Сапарбаев Бунёдбек 
Published: February 2023

В статье пойдет речь о произведении «Фирдаус ал-икбал» и изучении периода правления Мухаммада Рахимхана I зарубежными востоковедами. Приводится информация о вкладе зарубежных востоковедов в изучение периода правления Мухаммада Рахимхана I. Например, такие ученые, как А.Л. Кун, П.П. Иванов, В.В. Бартольд, Ю.Э. Брегель, тщательно проанализировали произведение «Фирдаус ал-икбал» и эпоху Мухаммад Рахимхана I. В статье представлены факты того, что это произведение является основным первоисточником в изучении истории Хорезма, особенно эпохи Мухаммад Рахимхана I. Это: перевод П.П. Иванова на русский язык части сочинения «Фирдаус ал-икбал» об истории туркмен; запись А.Л. Куном кратких заметок на основе рукописи «Фирдаус ал-икбал» о событиях в Хивинском ханстве от Абулгазихана до начала XIX века; В.В. Бартольд подготовил текст этого произведения, но бывшая советская цензура не разрешила публикацию, однако В.В.Бартольд высказал высокое мнение о произведении «Фирдаус ал-икбал» и был первым, кто представил это произведение на Западе; в 1988 году «Фирдаус ал-икбал» был переведен и издан историком Ю.Э.Брегелем на английском языке; в 2010 году произведение было опубликовано на узбекском языке. Кроме того, приводятся сведения о воспоминаниях путешественников, посетивших Хивинское ханство, Н.Н.Муравьева, Г.Вамбери, о Хивинском ханстве, хивинских ханах, таких как Мухаммад Рахимхан I, Сайид Мухаммадхан.
Психологик тренинг ёш раҳбарларнинг стрессга бардошлилигини ошириш усули сифатида
Authors: Инагамова Лола 
Published: February 2023

Мақолада ёш раҳбарларнинг стрессга бардошлилигини ошириш бўйича тренингнинг методологияси ва босқичлари муҳокама қилиган. Шунингдек, иш жойида ёш раҳбарлар учун стрессга бардошлилик бўйича тренингни тайёрлаш ва амалга ошириш юзасидан тренернинг малакаси ва компетенцияси таҳлил қилинади.
Presentación del monográfico “La Astronomía y la Astrología en la Literatura Española de los Siglos de Oro”
Authors: Balaguer Alba Gema , Collantes Sánchez Carlos 
Published: February 2023

RESUMEN: Presentación de la sección monográfica: La Astronomía y la Astrología en la Literatura Española de los Siglos de Oro.

ABSTRACT: Presentation of the monographic section: La Astronomía y la Astrología en la Literatura Española de los Siglos de Oro.
PENYULUHAN KESEHATAN PERILAKU HIDUP BERSIH DAN SEHAT SELAMA MASA PANDEMI COVID 19
Authors: Harahap Mei Adelina , Rangkuti Nur Aliyah , Rangkuti Juni Andriani 
Published: February 2023

Promosi kesehatan merupakan esensi dari peran tenaga kesehatan yang sebenarnya berdampak positif dalam upaya meningkatkan peran serta masyarakat dalam meningkatkan derajat kesehatan. Membiasakan pola hidup bersih dan sehat perlu diterapkan mulai dari sekarang, terutama di masa wabah Covid-19 ini. Pembiasaan PHBS bermaksud memberikan kegiatan rutin bagi seseorang terkait dengan pola hidup bersih dan sehat sehingga menjadi kebiasaan (Wiranata, 2020). Peran orang tua sangat penting dan berpengaruh dalam pembiasaan pola hidup bersih dan sehat dalam keluarga. Orang tua berkewajiban menentukan pilihan pelayanan kesehatan yang berkualitas bagi anggota keluarga seperti mengkonsumsi berbagai jenis makanan bergizi, dukungan emosional, aktivitas sehari-hari (aktivitas fisik), dan kualitas lingkungan (Inderan dan Weta, 2018). Oleh karena itu, pembiasaan pola hidup bersih dan sehat bagi anggota keluarga khususnya dan masyarakat selama wabah Covid-19 dapat berupa edukasi, baik berbasis teori maupun praktik langsung. Jika masyarakat membiasakan pola hidup bersih dan sehat sejak dini, maka secara tidak langsung masyarakat telah berperan aktif dalam memerangi COVID-19 di Indonesia.

Kata Kunci : Perilaku Hidup Bersih, Sehat

Abstract
Health promotion is the essence of the role of health workers who actually have a positive impact in an effort to increase community participation in improving the health status . Getting used to a clean and healthy lifestyle needs to be applied from now on, especially during this Covid-19 outbreak. PHBS habituation intends to provide a routine activity for someone related to a clean and healthy lifestyle so that it becomes a habit (Wiranata, 2020). The role of parents is very important and influential in the habituation of a clean and healthy lifestyle in the family. Parents are obliged to determine the choice of quality health services for family members such as consuming various types of nutritious food, emotional support, activities of daily living (physical activity), and environmental quality (Inderan and Weta, 2018). Therefore, habituation of a clean and healthy lifestyle for family members in particular and the community during the Covid-19 outbreak can be in the form of education, both theory-based and direct practice. If people get used to a clean and healthy lifestyle from an early age, then indirectly the community has played an active role in fighting COVID- 19 in Indonesia.
PENYULUHAN TENTANG KB KEPADA WUS DI DESA AEK HARUAYA KABUPATEN PADANG LAWAS UTARA
Authors: Harahap Ica Fauziah 
Published: February 2023

The Family Planning Program (KB) is an effort to regulate the birth of children, the ideal spacing and age of childbirth, and regulate pregnancy through the promotion of protection and assistance in accordance with reproductive rights to create the quality of families (BKKBN, 2018). The purpose of the dedication to the community is as a form of higher education tri dharma and to increase public knowledge, especially women of childbearing age, about family planning. This community service is by conducting counseling to women of childbearing age in the village of Aek Haruaya, with total 30. This counseling activity is held on Monday 21 November 2022 and run well. This activities are hoped that women of childbearing age can understand more about the family planning and expect support from their husbands.
PENYULUHAN RESIKO TINGGI PADA KEHAMILAN DI KLINIK ANUGRAH BINJAI TAHUN 2022
Authors: NINGSIH SAFARI FIFI RIA , SINAGA ELIZA BESTARI 
Published: February 2023

ABSTRAK

Kehamilan risiko tinggi adalah kehamilan yang akan menyebabkna terjadinya bahaya dan komplikasi yang lebih besar baik pada ibu maupun pada janin dalam kandungan dan dapat menyebabkan kematian, kesakitan, kecacatan, ketidaknyaman dan ketidakpuasan. Komplikasi pada saat kehamilan dapat dikategorikan dalam risiko kehamilan, sebanyak 90% penyebab utama terjadi karena komplikasi obstetric yang tidak terduga saat kehamilan, persalinan atau pasca persalinan dan 15% kehamilan diperkirakan berisiko tinggi dan dapat membahayakan ibu dan janin. Kegiatan ini di laksanakan di Klinik Anugrah Binjai di Pada tanggal 7 Desember 2022. Sasaran dalam kegiatan PKM ini adalah Ibu Hamil trimester I, II dan III. Hasil Analisis Deskriptif Tingkat Pengetahuan Ibu Hamil Pretest menunjukkan 3 (30%) ibu berpengetahan Baik dan Cukup 7 (70%) Kemudian hasil post-test yang didapatkan keseluruhan responden berpengetahuan baik tentang resiko tinggi pada kehamilan sebanyak 10 responden (100%). Bidan harus dapat mendeteksi sedini mungkin bahaya pada ibu hamil yang mungkin terjadi, karena setiap wanita hamil tersebut memiliki resiko mengalami komplikasi.
Modern aspects of surgical transformation of the perineum in patients with male transsexualism (literature review)
Authors: Istranov A. L. , Teyfukov S. N. , Sekacheva M. I. , Plotnikova M. V. 
Published: February 2023

Purpose of the study: a comparison of various vaginoplasty techniques and results in patients with transsexualism based on the analysis of data from the world scientific literature.Material and methods. The seeking of published research results placed in open databases by keywords. A total of 391 articles were initially analyzed of which 33 have met our acceptability criteria. A total of 3716 cases were analyzed where patients have undergone penile inversion, flap surgery (scrotal flap, free flap, rotational flap), endoscopic method and other modifications of vaginoplasty. The method includes comparing of the presented surgery techniques, their functional and aesthetic results, and complications rate.Results. Due to the involvement of different criteria for the results of surgical treatment evaluation by different scientific teams, as well as the insufficient number of objective studies on some methods, it is difficult to match the methods, their outcome, and complications. However, based on the described experience of practitioners and researchers, it can be concluded that the penile inversion technique is the most examined one and has a stable and appropriate results. Laparoscopic methods are equally effective but have a few specificities. The scrotal flap seems to be the most promising method that meets all the criteria for vaginoplasty in transsexuals. Free flaps or the rotational flaps usage has historical importance and could be used in certain circumstances.Conclusion. Various surgical techniques have demonstrated the safety and reliability of vaginoplasty in MtoF patients providing the low number of complications and a significant improvement in the patient's quality of life. Studies using different methods in a similar population and standardized results obtained from patients are required to further analyze the results of various methods to highlight the main principles for use in practice.