bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the impact of randomized control intervention on depressive symptoms in schoolchildren with atypical behaviors
Authors: Aneke Anthonia O. , Ede Moses Onyemaechi , Agbigwe Ifeanyichukwu B. , Obumse Nneka Anthonia , Nnamani Ogechi , Ngwoke Anthonia N. , Okenyi Emmanuel C. , Ezema Victor S. , Ejiofor Juliana N. , Njoku Obiageli C. , Ifelunni Clara O. , Ebizie Elizabeth N. , Okpala Edith , Oneli Joy Obiageli 
Published: February 2023

Background:
The need to investigate depression among disadvantaged groups motivated this study. This study investigated the impacts of rational emotive behavior therapy (REBT) on depressive symptoms in schoolchildren with atypical behaviors in Enugu State Nigeria.

Method:
A group randomized controlled design was used to assign 37 schoolchildren to the intervention group and 37 schoolchildren to the waitlisted control group. These people were evaluated at three times (pretest, post-test, and later test) using a dependent measure. The outcome demonstrated that there was no discernible difference between the participants in the treatment group and those in the waitlisted control group at the time of the pretest. The post-treatment test results revealed a considerable improvement among participants as a result of REBT therapy.

Results:
The later test result revealed that the treatment’s significant improvement was maintained in favor of the REBT group. The outcome of REBT treatment was not moderated due to location. The data showed a significant interaction impact on participants’ depression levels in relation to the interaction between groups and gender during therapy.

Conclusion:
Following the outcomes, we concluded that REBT is a long-term efficacious intervention for treating depressive symptoms in schoolchildren with atypical behaviors in Enugu State Nigeria regardless of location and gender.
Using acellular porcine dermal matrix (XCM Biologic® Tissue Matrix) to repair a giant omphalocele: A case report
Authors: Park Joo Yeon , Chung Jae Hee 
Published: February 2023

Rationale:
An omphalocele is an abdominal wall birth defect, and a giant omphalocele (GO) is defined as an omphalocele having a diameter >5 cm or containing a herniated liver. GOs are usually treated in stages and in this case, during the silo reduction, dehiscence occurred at the suture site of the axis ring and skin edge, which was repaired using synthetic absorbable mesh.

Patient concerns:
A girl infant was born at 36 weeks with a GO of 8 cm diameter, and herniated multiple organs such as the small bowel, cecum, appendix, and the entire liver. Even after the staged repair technique for the GO silo, wound dehiscence between the ring of the silo and the edge of the skin occurred and gradual reduction failed.

Diagnosis:
A GO of 8 cm diameter, which was found during prenatal ultrasonography.

Interventions:
Revision was performed to repair the defect. The small bowel and liver were still prolapsed, and there were severe adhesions. After adhesiolysis, the muscle layer of the abdominal wall was repaired using the tissue matrix, but the skin could not be repaired. After the second operation, the defect wound was dressed as sterilely as possible.

Outcomes:
The abdominal wall defect was repaired completely; there were no residual complications.

Lessons:
Repair of GOs using an acellular porcine dermal matrix can be considered a viable treatment option.
Clear cell “sugar” tumor of the lung: Diagnostic characteristics of a rare pulmonary tumor: A case report and review of literature
Authors: Wang Bo , Xu Xin , Zhao Zhenya 
Published: February 2023

Introduction:
Clear cell tumors of the lung (CCTLs), also known as “sugar tumors” for an abundant cellular glycogen concentration, are an extremely rare type pulmonary neoplasm. Often, they are incidentally found on chest roentgenogram or computed tomography scan during routine examination. CCTLs usually present with nonspecific symptoms that pose a diagnostic challenge to clinicians. Accordingly, histopathology remains the gold standard for diagnosing. Moreover, some of them can present with either appearances or histopathological features similar to other pulmonary neoplasms under the light microscope, including pulmonary malignancy, thereby causing misdiagnosis prior to or after surgery. Accordingly, herein, we describe a rare case of CCTL, review the literature has been published, and then discuss the benign versus malignant nature of this rare tumor.

Patient concerns:
A 59-year-old man presented due to a high-density chest nodule in the left diaphragm. The patient’s medical history was unremarkable and he also denied smoking in the past.

Diagnosis:
Physical examination, there were no noted signs. A new chest contrast-enhanced computed tomography revealed a 3.2 × 2.5 cm, solitary, circular nodule with a smooth edge located in the beside of the left thoracic aorta. Postoperative pathological and immunohistochemical examinations of the surgical specimens revealed a final diagnosis of CCTLs.

Interventions:
The patient underwent video-assisted thoracoscopic surgery. A wedge resection of left lower lung lobe was carried out and the tumor node was successfully removed alongside normal surrounding parenchyma.

Outcomes:
The operation was successful. Then the patient recovered completely and continued to do well on postsurgical thoracic surgical clinic visits. The tumor was a benign tumor, and the patient did not require any additional treatment. The patient had been followed-up regularly for 4 years after surgery; she did not experience any complications and remained disease-free.

Conclusion:
CCTLs should be considered in the differential diagnosis if a patient shows a solitary, circular chest nodule with a smooth edge. They are extremely rare lung tumors that must be differentiated from other lung tumors, especially the malignant tumors. Although pathological and immunohistochemical findings are important for making the diagnosis, the varying histopathological features on microscope make diagnosis difficult. The current case highlights the importance of physicians being aware of and suspecting CCTLs in similar cases, along with knowing the characteristics of CCTLs for the diagnosis and differential diagnosis.
Frontier and hotspot evolution in Brugada syndrome: A bibliometric analysis from 2002 to 2022
Authors: Liu Shixu , Xia Hongsheng , Yao Xiaoyan , Liu Hengyuan , Liu Yanyi , Xia Xiao , Wang Dandan , Liu Xiaohong , Li Guangxi 
Published: February 2023

Background:
Brugada syndrome (BrS) is a genetic disorder characterized by a typical electrocardiogram pattern and predisposition to arrhythmias and sudden cardiac death. Despite our considerably evolved understanding of BrS, no bibliometrics have been performed in this research field. We aimed to analyze and visualize the characteristics of the scientific outputs, topical evolutions, and research trends of BrS over the past 2 decades using bibliometric analysis.

Methods:
The literature associated with BrS was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection database. Acquired data were then visually analyzed using CiteSpace and VOSviewer.

Results:
3042 qualifying records were included in the final analysis. The publication outputs increased over time. The United States was the leading country in the BrS research. The University of Amsterdam (Netherlands) was the most prolific and influential institution. Pedro Brugada, Arthur Wilde, and Charles Antzelevitch exerted notable publication impact and made the most significant contributions in the field of BrS. Heart Rhythm had the highest outputs and Circulation was the most influential journal. Bundle branch block, ST-segment elevation, mechanism, management, right precordial lead, and guideline were the keywords with the strongest citation burst.

Conclusion:
Research on BrS is prosperous. Keywords and co-citation analysis revealed that the mechanism, diagnosis, risk stratification, and management of BrS were the research hotspots. Besides, the underlying pathophysiology, novel therapies, and personalized risk assessment might be the emerging trends of future research.
Natural History of Pediatric Cyclic Vomiting Syndrome: Progression to Dysautonomia
Authors: Gosalvez-Tejada Andrea , Li B U.K. , Simpson Pippa , Zhang Liyun , Kovacic Katja 
Published: February 2023

Background:
The clinical features of pediatric cyclic vomiting syndrome (CVS) often evolve over time. Many patients develop a constellation of chronic symptoms that suggest autonomic nervous system (ANS) dysfunction during adolescence. We aimed to determine the proportion of children with CVS who develop chronic rather than episodic symptoms consistent with ANS dysfunction.

Methods:
Retrospective chart review of children ages 0–18 years followed in an outpatient tertiary care CVS center. Patients completed standardized questionnaires at intake and follow-up visits, documenting clinical symptom pattern. Continuous variables are summarized as median [interquartile range (IQR)]. A Mann-Whitney test was used for group comparisons.

Results:
One hundred subjects were included. A total of 40% developed symptoms of ANS dysfunction (ANS+); 20% were confirmed by comprehensive ANS testing, 11% by orthostatic vital sign abnormalities, and 9% by clinical symptoms. The median (IQR) age at onset of chronic symptoms was 14 (10.02, 15) years. The presence of another disorder of gut-brain interaction (P = 0.018) and a greater number of comorbidities (P = 0.031) were more common in the ANS+ group. ANS+ subjects missed more school days (P= 0.047) and were seen less frequently in the emergency department (P = 0.023).

Conclusions:
Many children with CVS (40%) develop symptoms consistent with clinical dysautonomia in adolescence. These patients experience more comorbid conditions and a greater impact on school attendance, possibly representing a worsened quality of life as their disease course transitions to daily symptoms. When symptoms of CVS change over time, therapeutic interventions may need to be adjusted and targeted accordingly.
Childhood Adversity, Cognition, and Response to Cognitive Remediation in Major Depressive Disorder
Authors: Kinney-Huang Melinda , Leibovitz Talia , Harkness Kate L. , Bowie Christopher R. 
Published: February 2023

Abstract
Cognitive impairment is experienced by many individuals with major depressive disorder (MDD) and is significantly related to sustained disability. Recent work has begun to explore the relationship between childhood adversity (CA) and cognitive impairment in MDD, but this work is limited by unreliable measures of CA. Furthermore, no previous research has examined whether CA relates to cognitive remediation response. The current study clarifies how CA and clinical characteristics of illness explain cognitive variance. In addition, we investigate whether CA is associated with response to cognitive remediation. Thirty-nine individuals who completed cognitive remediation were rerecruited to complete a retrospective interview on CA. Results showed that CA, repeated depressive episodes, and earlier age at diagnosis were associated with poorer cognition. We did not observe a difference in treatment response based on CA. Findings suggest that CA is an important variable to consider when examining the expression of depressive illness and areas for intervention.
Current Practice and Practice Competencies of Clinical Nurse Specialists Working in US Emergency Care Settings
Authors: Wolf Lisa , Perhats Cydne , Delao Altair , Campbell Denise , Brim Carla , Campos Gabriel , House David , Rettig Amy , Williams Darlene , Chan Garrett K. 
Published: February 2023

Purpose/Aims
The aim of this study was to investigate the current practice of clinical nurse specialists working in US emergency care settings to (1) explicate the application of the Emergency Nurses Association core competencies and define the specialized clinical nurse specialist role in emergency care and (2) align current clinical nurse specialist practice in emergency settings with the National Association of Clinical Nurse Specialists core competencies and the identified substantive areas of clinical nurse specialist practice.

Design
This study used a quantitative exploratory descriptive approach using survey data.

Methods
A purposive convenience sample was recruited from the Emergency Nurses Association and the National Association of Clinical Nurse Specialists. Participants completed a 39-item survey based on a consensus process to develop competencies for emergency department (ED)–situated clinical nurse specialists.

Results
Respondents (n = 285) reported spending more than 50% of their work time in a primary clinical nurse specialist role. Significant differences in practice were found between geographic location, setting, educational preparation, title protection status, and type of institution.

Conclusions
Our findings suggest that that the competencies ascribed to ED-situated clinical nurse specialists are valid in both frequency and importance. However, ED-situated clinical nurse specialists are not fully credentialed or practicing to the full extent of their education and licenses, because of professional, legislative, and environmental limitations.
Multisite Evaluation of Toothbrushes and Microbial Growth in the Hospital Setting
Authors: DeJuilio Patti , Powers Jan , Soltis Lisa M. , Brooks Jo Ann 
Published: February 2023

Design
This observational, descriptive study was conducted to determine the prevalence of microbial growth on toothbrushes found in hospital patient rooms.

Methods
Toothbrush sampling was conducted in 136 acute care hospitals and medical centers from November 2018 through February 2022. Inclusion criteria for the units and patient rooms sampled were as follows: general adult medical-surgical units or critical care units; rooms occupied by adults 18 years or older who were capable of (1) mobilizing to the bathroom; (2) using a standard manual, bristled toothbrush; and (3) room did not have signage indicating isolation procedures.

Results
A total of 5340 patient rooms were surveyed. Of the rooms included, 46% (2455) of patients did not have a toothbrush available or had not used a toothbrush (still in package and/or toothpaste not opened). Of the used toothbrushes collected (n = 1817): 48% (872/1817) had at least 1 organism; 14% (251/1817) of the toothbrushes were positive for 3 or more organisms.

Conclusions
These results identify the lack of availability of toothbrushes for patients and support the need for hospitals to incorporate a rigorous, consistent, and comprehensive oral care program to address the evident risk of microbe exposure in the oral cavity.
Delivery of Community-based Antiretroviral Therapy to Maintain Viral Suppression and Retention in Care in South Africa
Authors: Wang Melody , Violette Lauren R. , Dorward Jienchi , Ngobese Hope , Sookrajh Yukteshwar , Bulo Elliot , Quame-Amaglo Justice , Thomas Katherine K. , Garrett Nigel , Drain Paul K. 
Published: February 2023

Background:
To determine whether the Centralized Chronic Medication Dispensing and Distribution (CCMDD) program in South Africa's differentiated ART delivery model affects clinical outcomes, we assessed viral load (VL) suppression and retention in care between patients participating in the program and those receiving the clinic-based standard of care.

Methods:
Clinically stable people living with HIV (PLHIV) eligible for differentiated care were referred to the national CCMDD program and followed up for up to 6 months. In this secondary analysis of trial cohort data, we estimated the association between routine patient participation in the CCMDD program and their clinical outcomes of viral suppression (<200 copies/mL) and retention in care.

Results:
Among 390 PLHIV, 236 (61%) were assessed for CCMDD eligibility; 144 (37%) were eligible, and 116 (30%) participated in the CCMDD program. Participants obtained their ART in a timely manner at 93% (265/286) of CCMDD visits. VL suppression and retention in care was very similar among CCMDD-eligible patients who participated in the program compared with patients who did not participate in the program (aRR: 1.03; 95% CI: 0.94–1.12). VL suppression alone (aRR: 1.02; 95% CI: 0.97–1.08) and retention in care alone (aRR: 1.03; 95% CI: 0.95–1.12) were also similar between CCMDD-eligible PLHIV who participated in the program and those who did not.

Conclusion:
The CCMDD program successfully facilitated differentiated care among clinically stable participants. PLHIV participating in the CCMDD program maintained a high proportion of viral suppression and retention in care, indicating that community-based ART delivery model did not negatively affect their HIV care outcomes.
Implications of predator species richness in terms of zoonotic spillover transmission of filoviral hemorrhagic fevers in Africa
Authors: Chang Taehee , Cho Sung-il , Min Kyung-Duk 
Published: February 2023

AbstractPrevious studies found that higher species richness of predators could reduce spillover risks of rodent-borne diseases. However, the effects on bat-borne diseases remains to be investigated. To this regard, we evaluated associations between predator species richness and the spillover events ofEbolavirusandMarburgvirus, the highly pathogenic bat-borne diseases in Africa. Stacked species distribution model approach was used to estimate predator species richness and Logistic regression analyses that considered spatiotemporal autocorrelations were conducted. The results showed that the third quartile (OR = 0.02, 95% CI 0.00–0.84) and fourth quartile (0.07, 0.00–0.42) of species richness of Strigiformes and the third quartile (0.15, CI 0.01–0.73) and fourth quartile (0.53, 0.03–0.85) of Colubridae showed significantly lower risks of spillover transmission ofEbolavirus. However, no significant association was found between predator species richness andMarburgvirusspillover. The results support a possible effect of predator species diversity on spillover suppression.
CD4+ and CD8+ T cell and antibody correlates of protection against Delta vaccine breakthrough infection: A nested case-control study within the PITCH study
Authors: Neale Isabel , Ali Mohammad , Kronsteiner Barbara , Longet Stephanie , Abraham Priyanka , Deeks Alexandra S. , Brown Anthony , Moore Shona C. , Stafford Lizzie , Dobson Susan L. , Plowright Megan , Newman Thomas A.H. , Wu Mary Y ,   Crick COVID Immunity Pipeline, Carr Edward J , Beale Rupert , Otter Ashley D , Hopkins Susan , Hall Victoria , Tomic Adriana , Payne Rebecca P. , Barnes Eleanor , Richter Alex , Duncan Christopher J.A. , Turtle Lance , de Silva Thushan I. , Carroll Miles , Lambe Teresa , Klenerman Paul , Dunachie Susanna 
Published: February 2023

ABSTRACTT cell correlates of protection against SARS-CoV-2 infection after vaccination (‘vaccine breakthrough’) are incompletely defined, especially the specific contributions of CD4+ and CD8+ T cells. We studied 279 volunteers in the Protective Immunity from T Cells in Healthcare Workers (PITCH) UK study, including 32 cases (with SARS-CoV-2 positive testing after two vaccine doses during the Delta-dominant era) and 247 controls (no positive test nor anti-nucleocapsid seroconversion during this period). 28 days after second vaccination, before all breakthroughs occurred, cases had lower ancestral S- and RBD-specific immunoglobulin G titres and S1- and S2-specific T cell interferon gamma (IFNγ) responses compared with controls. In a subset of matched cases and controls, cases had lower CD4+ and CD8+ IFNγ and tumour necrosis factor responses to Delta S peptides with reduced CD8+ responses to Delta versus ancestral peptides compared with controls. Our findings support a protective role for T cells against Delta breakthrough infection.
Parental education and income are linked to offspring cortical brain structure and psychopathology at 9-11 years
Authors: Norbom Linn B. , Rokicki Jaroslav , Eilertsen Espen M. , Wiker Thea , Hanson Jamie , Dahl Andreas , Alnæs Dag , Fernández-Cabello Sara , Beck Dani , Agartz Ingrid , Andreassen Ole A. , Westlye Lars T. , Tamnes Christian K. 
Published: February 2023

AbstractBackgroundA child’s socioeconomic environment can shape central aspects of their life, including vulnerability to mental disorders. Negative environmental influences in youth may interfere with the extensive and dynamic brain development occurring at this time. Indeed, there are numerous yet diverging reports of associations between parental socioeconomic status (SES) and child cortical brain morphometry. Most of these studies have used single metric- or unimodal analyses of standard cortical morphometry that downplay the probable scenario where numerous biological pathwaysin sumaccount for SES-related cortical differences in youth.MethodsTo comprehensively capture such variability, using data from 9758 children aged 8.9-11.1 years from the ABCD Study®, we employed linked independent component analysis (LICA) and fused vertex-wise cortical thickness, surface area, curvature and grey-/white-matter contrast (GWC). LICA revealed 70 uni- and multimodal components. We then assessed the linear relationships between parental education, parental income and each of the cortical components, controlling for age, sex, genetic ancestry, and family relatedness. We also assessed whether cortical structure moderated the negative relationships between parental SES and child general psychopathology.ResultsParental education and income were both associated with larger surface area and higher GWC globally, in addition to local increases in surface area and to a lesser extent bidirectional GWC and cortical thickness patterns. The negative relation between parental income and child psychopathology were attenuated in children with a multimodal pattern of larger frontal- and smaller occipital surface area, and lower medial occipital thickness and GWC.ConclusionStructural brain MRI is sensitive to SES diversity in childhood, with GWC emerging as a particularly relevant marker together with surface area. In low-income families, having a more developed cortex across MRI metrics, appears beneficial for mental health.
Rational Prediction of PROTAC-compatible Protein-Protein Interfaces by Molecular Docking
Authors: Pereira Gilberto P. , Jiménez-García Brian , Pellarin Riccardo , Launay Guillaume , Wu Sangwook , Martin Juliette , Souza Paulo C. T. 
Published: February 2023

AbstractProteolysis targeting chimeras (PROTACS) are heterobifunctional ligands that mediate the interaction between a protein target and an E3 ligase, resulting in a ternary complex whose interaction with the ubiquitination machinery leads to target degradation. This technology is emerging as an exciting new avenue for therapeutic development, with several PROTACS currently undergoing clinical trials targeting cancer. Here, we describe a general and computationally efficient methodology combining restraint-based docking, energy-based rescoring, and a filter based on minimal solvent-accessible surface distance to produce PROTAC-compatible PPIs suitable for when there is noa prioriknown PROTAC ligand. In a benchmark employing a manually curated dataset of 13 ternary complex crystals, we achieved accuracy of 92% when starting from bound structures, and 77% when starting from unbound structures, respectively. Our method only requires that the ligand-bound structures of the monomeric forms of the E3 ligase and target proteins be given to run, making it general, accurate and highly efficient, with the ability to impact early stage PROTAC-based drug design campaigns where no structural information about the ternary complex structure is available.