bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Integration of the Polish National Minority in Lithuania
Authors: Starovoitova S. S. , Lebedintseva L. A. 
Published: March 2023

Introduction. This article aims to examine social integration of national minorities in Lithuania. The scientific novelty of this study represents identification of the main social mechanisms that influence the integration of national minorities. The author focuses on the integration of Polish minority due to their large number and active political position.Methodology and sources. Throughout the study, big attention was paid to the scientific articles and monographs of Lithuanian sociologists, thanks to which the term “social integration” in relation to the Lithuanian case, the identity of the Poles living in Lithuania, as well as the integration of national minorities into Lithuanian society through the education system were studied. Moreover, expert and narrative interviews with representatives of the Polish minority were conducted in order to better understand the situation.Results and discussion. Based on the data, the authors came to the conclusion that current legislation creates favorable conditions for the protection of the rights of national minorities, contributes to the preservation of their identity and development of culture. However, representatives of national minorities express the desire to have a separate law on national minorities that would clearly define and regulate their rights. Lithuanian language skills are seen as an important indicator evaluating integration of national minorities.Conclusion. The education system creates opportunities for national minorities to acquire necessary competencies and learn Lithuanian language. Communication contributes to the improvement of language skills. Good knowledge of Lithuanian language contributes to the expansion of the circle of contacts and integration into the Lithuanian social system.
Motivational Portrait of Digital Generation Applicant
Authors: Strogetskaya E. V. , Betiger I. B. 
Published: March 2023

Introduction. The relevance of the topic is due to the need to develop principles and methods of sociological support for the process of professional self-determination of young people in the digital environment. The article presents the results of studies of socioprofessional aspirations, value orientations and motivation for acquiring a profession among modern applicants. An analysis was made of some cognitive features of school graduates that influence their choice of specialization and university.Methodology and sources. The methodological base included the activity theories of motivation by A.N. Leontiev and L.S. Vygotsky, the psychology of the attitude of D.N. Uznadze, modern sociological studies of the rational choice of a university by applicants (L. Abdrakhmanova, E. Nikonova, J. Kinzie, M. Palmer, J. Hayek, D. Hossler, S.A. Jacob et al.). To solve the problems of analyzing the construction of the reality of higher education with the help of visual images, the authors relied on the traditions of visual sociology.Results and discussion. The empirical basis for writing the article was the results of a seven-year monitoring (2015–2021) “Motives and factors for choosing a university by applicants for technical specialties” (N = 3700 people) of one of the leading universities in Russia – Saint Petersburg Electrotechnical University. An analysis of the dynamics of the value-motivational portrait of young people showed that applicants belonging to generation Z are distinguished by mobilization motivation and pragmatic values. The hypothesis about the influence of the principle of obtaining the result “here and now” on the decisions made by future engineers from the digital generation was confirmed. The results obtained lead to the conclusion that in order to increase the level of professional motivation and attract generation Z to enroll in a university, a radical change in the field of communicative interaction from “offline” to “online” is necessary.Conclusion. In conclusion, the authors of the article, based on the results of their research, suggest some directions for the development of communication strategies in working with applicants of the digital generation, emphasizing that an important component of the success of the communication strategy of a modern university in interaction with young people is high-quality, fast and regular feedback using message visualization tools.
Estado de la motricidad fina pospandemia: Un diagnóstico en niños de 5 a 6 años de edad en Quito, Ecuador
Authors: Vásconez Erazo Rachel , Yarad Jeada Valeria 
Published: March 2023

El objetivo de este trabajo es analizar el estado de la motricidad fina después del retorno a clases en niños de 5 a 6 años de edad en dos escuelas de Quito. Para ello, se aplicó un test observacional a una muestra intencional de 74 niños, 44 de una escuela privada y 30 de una escuela pública. El instrumento reunió once indicadores sobre la coordinación óculo-manual, el uso de la pinza digital y otras destrezas. Para el análisis se utilizó estadística descriptiva, y para contrastar la hipótesis con relación a la diferencia entre centros educativos se usaron el estadístico Wilcoxon Signed-Rank Test y el p-value. Entre los principales resultados, no existen diferencias entre ambas escuelas, excepto en un indicador. Sin embargo, hay funciones motoras que aún no han sido alcanzadas, entre ellas el manejo de la pinza digital y atarse los cordones de los zapatos. Además, las niñas obtuvieron mejores resultados que los varones. Como conclusión, la pandemia sí pudo haber generado un impacto en algunas destrezas que los niños a esa edad ya deben tener adquiridas. No obstante, en Ecuador no hay estudios previos que avalen que el confinamiento fuera la causa de las dificultades para alcanzar estas habilidades.
THE ANALYSIS OF THE MAIN CHARACTER IN SHORT STORY THE HUSBAND STITCH BY CARMEN MARIA MACHADO
Authors: Rizki Ananda Maulana Alfian 
Published: February 2023

The study entitled The Analysis of the Main Character in Short Story The Husband Stitch by Carmen Maria Machado is aimed to find out the psychological, sociological, and physiological dimensions of the main character and the methods of characterization used by the author to present the main character in this story. There were some theories used in this study such as the theory about characterization by Griffith (1982), and the theory about the dimension of character by Wellek and Warren (1955). The author uses a direct method to represent the main character to the readers. After analyzing, the author describes the main character of “I” as a beautiful girl who comes from a good family. She has some secret about the ribbon on her neck, and she does not want someone else to know about it, even her husband. The main character in this story experienced a dynamic character. The main character of “I”, who at first did not want to show what was behind her green ribbon, finally changed her mind and showed what she had been hiding from her husband.
Effect of the clenching of teeth on the posture: differences between bruxer′s and unbruxer′s population
Authors: Siffre M. , Bertucci W. , Soudain-Pineau M. 
Published: February 2023

Objectives. Relying on the Thegosis theory, the purpose of this study is to analyze the effects of the clenching of teeth on the posture with a stabilometric platform.Method. Thirty-two subjects divided into two groups, Bruxism and Control using criteria from O. F. Molina and al., have passed two series of three stabilometric measures: unclenched teeth then clenched teeth. Posturological parameters analyzed in this study are: X-moyen, Y-moyen, Surface, LFS, VFY.Results. Statistical analysis of the data reveals significant differences for the X-moyen, the Surface and the VFY. Conclusion. This study shows that if unclenched teeth, bruxer subjects have a similar posture to the control subjects, clenched teeth have different postures and clenching of teeth tends to stabilize the bruxers and destabilize the control subjects.
Changes in the VARK Learning Style from the First to the Second Preclinical Year of Medical Students: A Follow-up Cross-sectional Questionnaire Study in a Thai Medical School
Authors: Maprapho Punyapat , Sitticharoon Chantacha , Maikaew Pailin , Lertsiripatarajit Vasu , Keadkraichaiwat Issarawan , Charoenngam Nipith Charoenngam 
Published: March 2023

Objective: This study aimed to determine percentage of students who changed (change group) and did not change (no-change group) in the visual (V)–aural (A)–reading/writing (R)–kinesthetic (K) learning style from the first (Preclinic1) to the second (Preclinic2) preclinical year; and compare academic performance (GPA, percentile of GPA, and achievement of study targets) and stress levels between these groups.
Materials and Methods: The VARK and research questionnaires were sent to students of the 2019 class at the end of Preclinic1 and again at Preclinic2. GPA and percentile of GPA were obtained from academic records while achievement of study targets and stress levels were from the research questionnaires.
Results: Most students were multimodal learners (65.03% in Preclinic1 and 69.51% in Preclinic2). From Preclinic1 to Preclinic2, 69.3% of students changed and 30.7% of students did not change their learning preference. In Preclinic1 and Preclinic2, GPA and percentile of GPA were higher in the no-change compared with the change group (p<0.01 all). GPA in the change group was lower in Preclinic2 than that in Preclinic1 (p<0.001). Achievement of study targets and stress levels of the change group in Preclinic2 were lower than theirs in Preclinic1 and those of the no-change group in Preclinic2 (p<0.05 all). The students who changed their learning preference might need to adapt to their new learning preference probably leading to lower academic capability but less stress.
Conclusion: Students changed their learning preference around 70% from Preclinic1 to Preclinic2. The change group exhibited lower academic capability but less stress.
Emotion Regulation and Behavioral Problems in Children with Autism Spectrum Disorder: A University Hospital Based Cross-Sectional Study
Authors: Hosiri Tikumporn , Sittanomai Napat , Bumrungtrakul Thanchanok , Boon-yasidhi Vitharon 
Published: March 2023

Objective: The objectives of this study were to investigate behavioral problems and emotion regulation in children with autism spectrum disorder (ASD) with and without psychiatric comorbidities, and to assess the correlation between emotion regulation and behavioral problems.
Materials and Methods: Participants included 65 children with ASD (ASD group) and 65 children with ASD and psychiatric comorbidities (ASD+CPD group), aged 6 to 12, and their caretakers. Emotion regulation was assessed by the Emotion Regulation Checklist (ERC). Behavioral problems were assessed by the Strengths and Difficulties Questionnaire (SDQ).
Results: An independent sample T-test revealed that the ASD+CPD group had poorer emotion regulation, greater emotion lability/negativity, and a higher total difficulty score when compared to the ASD group. The Pearson’s Correlation Coefficient indicated that emotion regulation (r = -0.47, p<0.05) and lability/negativity (r = 0.65, p<0.05) correlated with the total difficulties score of the SDQ. A multiple regression analysis revealed that lower emotion regulation and higher emotion lability/negativity predicted an increase in behavioral problems (R2 = 0.44, p<0.05).
Conclusions: We found that children with ASD and psychiatric comorbidities had poorer emotion regulation and more behavioral problems than those without comorbidities, and that poorer emotion regulation predicts behavioral problems. These results indicate that children with ASD should be assessed for psychiatric comorbidities, particularly those who have emotional dysregulation and behavioral problems.
Predictive Factors of Intravesical Recurrence after Ureteroscopy in Upper Urinary Tract Urothelial Carcinoma Followed by Radical Nephroureterectomy
Authors: Srinualnad Sittiporn , Sawangchareon Atichet , Jongjitaree Kantima , Phinthusophon Kittipong , Taweemonkongsap Tawatchai , Leewansangtong Sunai , Nualyong Chaiyong , Liangkobkit Karn , Chotikawanich Ekkarin 
Published: March 2023

Objective: To investigate the risk factors of developing intravesical recurrence (IVR) in patients with upper urinary tract urothelial carcinoma (UTUC) who underwent ureterorenoscopy (URS) before radical nephroureterectomy with bladder cuff excision (RNU).
Materials and Methods: This retrospective study collected data from the medical records of patients diagnosed with UTUC between January 2012 and December 2019. All the patients underwent ureteroscopy before radical surgery. Patients previously diagnosed with bladder cancer were excluded. A total of 63 patients were included in the study. Tumour factors, such as multiplicity, location, size, histologic grade, pathologic T-stage, and lymphovascular invasion status, were evaluated. The type of endoscopic procedure and time interval between URS and RNU were analysed to determine the factors affecting IVR.
Results: The associated factors with IVR included multifocal tumours (HR = 4.8(1.9–11.9)), large size tumours greater than or equal to 4 cm (HR = 3.3(1.5–7.0)), and time interval greater than or equal to 5 weeks between URS and RNU (HR = 2.6(1.2–5.5)). Factors including tumour location (kidney or ureter), size, grading, T-stage, and lymphovascular invasion as well as the type of endoscopic procedure were not at high risk for IVR.
Conclusion: The predictive factors of IVR for UTUC patients who underwent URS before RNU included a multiplicity of primary tumours and a tumour size greater than or equal to 4 cm, while a time interval between URS and RNU greater than or equal to 5 weeks increased the risk of IVR.
Functional optimization of light-activatable Opto-GPCRs: Illuminating the importance of the proximal C-terminus in G-protein specificity
Authors: Leemann Siri , Kleinlogel Sonja 
Published: March 2023

Introduction: G-protein coupled receptors (GPCRs) are the largest family of human receptors that transmit signals from natural ligands and pharmaceutical drugs into essentially every physiological process. One main characteristic of G-protein coupled receptors is their ability to specifically couple with different families of G-proteins, thereby triggering specific downstream signaling pathways. While an abundance of structural information is available on G-protein coupled receptorn interactions with G-proteins, little is known about the G-protein coupled receptor domains functionally mediating G-protein specificity, in particular the proximal C-terminus, the structure which cannot be predicted with high confidentiality due to its flexibility.Methods: In this study, we exploited OptoGPCR chimeras between lightgated G-protein coupled receptors (opsins) and ligand-gated G-protein coupled receptors to systematically investigate the involvement of the C-terminus steering G-protein specificity. We employed rhodopsin-beta2-adrenoceptor and melanopsin-mGluR6 chimeras in second messenger assays and developed structural models of the chimeras.Results: We discovered a dominant role of the proximal C-terminus, dictating G-protein selectivity in the melanopsin-mGluR6 chimera, whereas it is the intracellular loop 3, which steers G-protein tropism in the rhodopsin-beta2-adrenoceptor. From the functional results and structural predictions, melanopsin and mGluR6 use a different mechanism to bovine rhodopsin and b2AR to couple to a selective G-protein.Discussion: Collectively, this work adds knowledge to the G-protein coupled receptor domains mediating G-protein selectivity, ultimately paving the way to optogenetically elicited specific G-protein signaling on demand.
Aberrant lipid accumulation in the mouse visceral yolk sac resulting from maternal diabetes and obesity
Authors: Zhang Man , Salbaum J. Michael , Jones Sydney , Burk David , Kappen Claudia 
Published: March 2023

Maternal diabetes and obesity in pregnancy are well-known risk factors for structural birth defects, including neural tube defects and congenital heart defects. Progeny from affected pregnancies are also predisposed to developing cardiometabolic disease in later life. Based upon in vitro embryo cultures of rat embryos, it was postulated that nutrient uptake by the yolk sac is deficient in diabetic pregnancies. In contrast, using two independent mouse models of maternal diabetes, and a high-fat diet-feeding model of maternal obesity, we observed excessive lipid accumulation at 8.5 days in the yolk sac. The numbers as well as sizes of intracellular lipid droplets were increased in yolk sacs of embryos from diabetic and obese pregnancies. Maternal metabolic disease did not affect expression of lipid transporter proteins, including ApoA1, ApoB and SR-B1, consistent with our earlier report that expression of glucose and fatty acid transporter genes was also unchanged in diabetic pregnancy-derived yolk sacs. Colocalization of lipid droplets with lysosomes was significantly reduced in the yolk sacs from diabetic and obese pregnancies compared to yolk sacs from normal pregnancies. We therefore conclude that processing of lipids is defective in pregnancies affected by maternal metabolic disease, which may lead to reduced availability of lipids to the developing embryo. The possible implications of insufficient supply of lipids -and potentially of other nutrients-to the embryos experiencing adverse pregnancy conditions are discussed.
Extracellular vesicles from medicated plasma of Buyang Huanwu decoction-preconditioned neural stem cells accelerate neurological recovery following ischemic stroke
Authors: Long Jun , Gu Chenyang , Zhang Qiankun , Liu Jiale , Huang Jiajun , Li Yajing , Zhang Yifan , Li Rong , Ahmed Waqas , Zhang Jianfeng , Khan Ahsan Ali , Cai Hengsen , Hu Yong , Chen Lukui 
Published: March 2023

Introduction: The neurological impairment of survivors after ischemic stroke poses a serious risk to their quality of life and health. Effective therapeutic options are still lacking. Neural stem cells (NSCs) promote neurogenesis via secreted extracellular vesicles (NSC-EVs), which would be a potential therapeutic option, but the insufficient quantity of NSC-EVs in vivo restrains clinical application. Buyang Huanwu Decoction (BHD), a classic traditional Chinese medicine (TCM) decoction, is promising to alleviate neurological impairment after ischemic stroke. It was speculated that BHD might promote neurological recovery through the NSC-EVs.Methods: The medicated plasma of BHD (MP-BHD) was prepared to precondition NSCs and isolate EVs (BHD-NSC-EVs). Middle cerebral artery occlusion (MCAO) models and primary NSCs were administered to evaluate the therapeutic effect. Next-generation sequencing was performed to explore the mechanism.Results: The BHD-NSC-EVs more significantly accelerated neurological recovery after MCAO and promoted NSCs proliferation and differentiation than BHD and NSC-EVs alone. MP-BHD enhanced the largescale generation of BHD-NSC-EVs, which encapsulated functional miRNA and may play critical roles in neurogenesis.Discussion: In replacing BHD or NSCs, the preconditioned NSC-EVs present a more efficient therapeutic strategy for ischemic stroke. Based on the clinical efficacy of TCM, the preconditioning of NSC-derived EVs via the MP of TCM herbs would presents a newly promising therapeutic strategy for neurological diseases.
Coexistence of tmexCD3-toprJ1b tigecycline resistance genes with two novel blaVIM-2-carrying and blaOXA-10-carrying transposons in a Pseudomononas asiatica plasmid
Authors: Li Qin , Chen Qiao , Liang Shuang , Wang Wei , Zhang Bingying , Martín-Rodríguez Alberto J. , Liang Qinghua , Zhang Feiyang , Guo Ling , Xiong Xia , Hu Renjing , Xiang Li , Zhou Yingshun 
Published: March 2023

IntroductionTigecycline and carbapenems are considered the last line of defense against microbial infections. The co-occurrence of resistance genes conferring resistance to both tigecycline and carbapenems in Pseudomononas asiatica was not investigated.MethodsP. asiatica A28 was isolated from hospital sewage. Antibiotic susceptibility testing showed resistance to carbapenem and tigecycline. WGS was performed to analyze the antimicrobial resistance genes and genetic characteristics. Plasmid transfer by conjugation was investigated. Plasmid fitness costs were evaluated in Pseudomonas aeruginosa transconjugants including a Galleria mellonella infection model.ResultsMeropenem and tigecycline resistant P. asiatica A28 carries a 199, 972 bp long plasmid PLA28.4 which harbors seven resistance genes. Sequence analysis showed that the 7113 bp transposon Tn7389 is made up of a class I integron without a 5’CS terminal and a complete tni module flanked by a pair of 25bp insertion repeats. Additionally, the Tn7493 transposon, 20.24 kp long, with a complete 38-bp Tn1403 IR and an incomplete 30-bp Tn1403 IR, is made up of partial skeleton of Tn1403, a class I integron harboring blaOXA-10, and a Tn5563a transposon. Moreover, one tnfxB3-tmexC3.2-tmexD3b-toprJ1b cluster was found in the plasmid and another one in the the chromosome. Furthermore, plasmid PLA28.4 could be conjugated to P. aeruginosa PAO1, with high fitness cost.DiscussionA multidrug-resistant plasmid carrying tmexCD3-toprJ1b and two novel transposons carrying blaVIM-2 and blaOXA-10 -resistant genes was found in hospital sewage, increasing the risk of transmission of antibiotic-resistant genes. These finding highlight the necessary of controlling the development and spread of medication resistance requires continuous monitoring and management of resistant microorganisms in hospital sewage.
Impact of severe secondary tricuspid regurgitation on rest and exercise hemodynamics of patients with heart failure and a preserved left ventricular ejection fraction
Authors: Baratto Claudia , Caravita Sergio , Corbetta Giorgia , Soranna Davide , Zambon Antonella , Dewachter Céline , Gavazzoni Mara , Heilbron Francesca , Tomaselli Michele , Radu Noela , Perelli Francesco Paolo , Perego Giovanni Battista , Vachiéry Jean-Luc , Parati Gianfranco , Badano Luigi P. , Muraru Denisa 
Published: March 2023

BackgroundBoth secondary tricuspid regurgitation (STR) and heart failure with preserved ejection fraction (HFpEF) are relevant public health problems in the elderly population, presenting with potential overlaps and sharing similar risk factors. However, the impact of severe STR on hemodynamics and cardiorespiratory adaptation to exercise in HFpEF remains to be clarified.AimTo explore the impact of STR on exercise hemodynamics and cardiorespiratory adaptation in HFpEF.MethodsWe analyzed invasive hemodynamics and gas-exchange data obtained at rest and during exercise from HFpEF patients with severe STR (HFpEF-STR), compared with 1:1 age-, sex-, and body mass index (BMI)- matched HFpEF patients with mild or no STR (HFpEF-controls).ResultsTwelve HFpEF with atrial-STR (mean age 72 years, 92% females, BMI 28 Kg/m2) and 12 HFpEF-controls patients were analyzed. HFpEF-STR had higher (p &lt; 0.01) right atrial pressure than HFpEF-controls both at rest (10 ± 1 vs. 5 ± 1 mmHg) and during exercise (23 ± 2 vs. 14 ± 2 mmHg). Despite higher pulmonary artery wedge pressure (PAWP) at rest in HFpEF-STR than in HFpEF-controls (17 ± 2 vs. 11 ± 2, p = 0.04), PAWP at peak exercise was no more different (28 ± 2 vs. 29 ± 2). Left ventricular transmural pressure and cardiac output (CO) increased less in HFpEF-STR than in HFpEF-controls (interaction p-value &lt; 0.05). This latter was due to lower stroke volume (SV) values both at rest (48 ± 9 vs. 77 ± 9 mL, p &lt; 0.05) and at peak exercise (54 ± 10 vs. 93 ± 10 mL, p &lt; 0.05). Despite these differences, the two groups of patients laid on the same oxygen consumption isophlets because of the increased peripheral oxygen extraction in HFpEF-STR (p &lt; 0.01). We found an inverse relationship between pulmonary vascular resistance and SV, both at rest and at peak exercise (R2 = 0.12 and 0.19, respectively).ConclusionsSevere STR complicating HFpEF impairs SV and CO reserve, leading to pulmonary vascular de-recruitment and relative left heart underfilling, undermining the typical HFpEF pathophysiology.