bluuebunny/crossref_metadata_2025_split huggingface dataset:
ICP: Volmume 10, n° 2, 2009 - Full Issue
Authors: Journal system  
Published: July 2023

Table/Contents
L’interc­ontinentale de la fin de la fin de l’Histoire et les c­ontours d’un nouvel humanisme antilibéral : Naxal, Cabral, San Cristobal et Népal

Jean-Jacques Ngor Sène ............................................... 1
Democracy and Election After Democratization in South Korea
Jung, Young-Tae ....................................... 32
Developing Sustainable Communities in Africa : Components for a Framework
Olajide Oloyede ................................................... 56
Sri Lanka on the Verge on Non-Violence : Can Violence lead to a Stable Peace ?
Rumana Monzur ................................................... 65
Freedom, Race, and Francophonie : Gandhi and The Construction of Peoplehood
Anil Nauriya, Advocate Supreme court of India................... 78
Book Review
Darwis Khudori (Ed.), Rethinking solidarity in global society. The challenge of globalisation for social and solidarity movements. 50 years after Bandung Asian-African Conference 1955, Ed. SIRD, Malaysia, 2007, 202
Par Lazare Ki-Zerbo ...................................... 96
Charles Renel, (1866-1925), L’oncle d’Afrique ou La Métisse, annoté et commenté par Claude Bavoux; Avant-propos de Jean François Reverzy. Coédition ORPHIE, Grand Océan, 218 p. 2005.
Par Dominique Bois ....................................... 98
Deepak K. Singh, Stateless in South Asia ; The Chakmas between Bangladesh and India, Sage Publication, India, 2010, Page; 289,
By Chunnu Prasad ................................... 103
Ultrahigh Sensitivity Solar‐Blind UV Detection via Multistage‐Concentric‐Annulus Architecture Metasurface
Authors: Cai Qing , Zhi Ting , You Haifan , Shao Pengfei , Chen Kai , Wang Jin , Guo Hui , Xue Junjun , Tao Tao , Liu Bin , Xie Zili , Cao Xun , Lu Hai , Zheng Youdou , Zhang Rong , Chen Dunjun 
Published: July 2023

AbstractHigh‐sensitivity photodetection capability has become an indispensable requirement for detecting feeble solar‐blind ultraviolet (UV) light. Micro‐nano metallic metasurface structures are employed to enhance the detector photoelectric performances. However, existing approaches are confronted with bottlenecks of structure simplification and efficacy mediocrity. Here, a distinctive diamond solar‐blind UV photodetector with a synthetic multistage‐concentric‐annulus (MCA) architecture metasurface is reported, which is prepared through a facile and peculiar Fraunhofer diffraction technique. The detector achieves an excellent photo‐to‐dark‐current ratio of 2.4×108 and maintains an extremely low dark current on the order of pA magnitude. The intrinsic response peak and resonance absorption phenomenon in solar‐blind UV are evident from the optical properties. Moreover, the surface potential distribution intuitively reveals that plasmon resonance enhances the UV scattering and absorption cross sections, thus facilitating the photogeneration of carriers. Meanwhile, it expressly demonstrates that multi‐level dipole interaction in the MCA structure accelerates the separation and extraction of electron–hole pairs through enhancing the localized electric field intensity. In addition, a wide range of variable temperature measurements further prove the device possesses capacity for working in extreme environments. This photodetection technology by virtue of a delicate and viable diffraction metasurface is anticipated to provide a leap forward for future applications in wide‐band‐gap semiconductor UV detectors.
The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma
Authors: Smith Philip , Bradley Thomas , Gavarró Lena Morrill , Goranova Teodora , Ennis Darren P. , Mirza Hasan B. , De Silva Dilrini , Piskorz Anna M. , Sauer Carolin M. , Al-Khalidi Sarwah , Funingana Ionut-Gabriel , Reinius Marika A. V. , Giannone Gaia , Lewsley Liz-Anne , Stobo Jamie , McQueen John , Bryson Gareth , Eldridge Matthew ,   The BriTROC Investigators, Glasspool R. M. , Gourley C. , Kennedy R. , Hall G. , Edmondson R. , Clamp A. , Sundar S. , Walter A. , Hall M. , Gabra H. , Fotopoulou C. , Brockbank E. , Montes A. , Lockley M. , Macintyre Geoff , Markowetz Florian , Brenton James D. , McNeish Iain A. 
Published: July 2023

AbstractThe drivers of recurrence and resistance in ovarian high grade serous carcinoma remain unclear. We investigate the acquisition of resistance by collecting tumour biopsies from a cohort of 276 women with relapsed ovarian high grade serous carcinoma in the BriTROC-1 study. Panel sequencing shows close concordance between diagnosis and relapse, with only four discordant cases. There is also very strong concordance in copy number between diagnosis and relapse, with no significant difference in purity, ploidy or focal somatic copy number alterations, even when stratified by platinum sensitivity or prior chemotherapy lines. Copy number signatures are strongly correlated with immune cell infiltration, whilst diagnosis samples from patients with primary platinum resistance have increased rates of CCNE1 and KRAS amplification and copy number signature 1 exposure. Our data show that the ovarian high grade serous carcinoma genome is remarkably stable between diagnosis and relapse and acquired chemotherapy resistance does not select for common copy number drivers.
IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation
Authors: Mishra Vishwas , Crespo-Puig Anna , McCarthy Callum , Masonou Tereza , Glegola-Madejska Izabela , Dejoux Alice , Dow Gabriella , Eldridge Matthew J. G. , Marinelli Luciano H. , Meng Meihan , Wang Shijie , Bennison Daniel J. , Morrison Rebecca , Shenoy Avinash R. 
Published: July 2023

AbstractThe cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1. UBE2L3, a ubiquitin conjugating enzyme, promotes pro-IL-1β ubiquitylation and proteasomal disposal. However, actions of UBE2L3 in vivo and its ubiquitin ligase partners in this process are unknown. Here we report that deletion ofUbe2l3in mice reduces pro-IL-1β turnover in macrophages, leading to excessive mature IL-1β production, neutrophilic inflammation and disease following inflammasome activation. An unbiased RNAi screen identified TRIP12 and AREL1 E3 ligases of the Homologous to E6 C-terminus (HECT) family in adding destabilising K27-, K29- and K33- poly-ubiquitin chains on pro-IL-1β. We show that precursor abundance determines mature IL-1β production, and UBE2L3, TRIP12 and AREL1 limit inflammation by shrinking the cellular pool of pro-IL-1β. Our study uncovers fundamental processes governing IL-1β homeostasis and provides molecular insights that could be exploited to mitigate its adverse actions in disease.
Neural signatures of social inferences predict the number of real-life social contacts and autism severity
Authors: Tusche Anita , Spunt Robert P. , Paul Lynn K. , Tyszka Julian M. , Adolphs Ralph 
Published: July 2023

AbstractWe regularly infer other people’s thoughts and feelings from observing their actions, but how this ability contributes to successful social behavior and interactions remains unknown. We show that neural activation patterns during social inferences obtained in the laboratory predict the number of social contacts in the real world, as measured by the social network index, in three neurotypical samples (totaln = 126) and one sample of autistic adults (n = 23). We also show that brain patterns during social inference generalize across individuals in these groups. Cross-validated associations between brain activations and social inference localize selectively to the right posterior superior temporal sulcus and were specific for social, but not nonsocial, inference. Activation within this same brain region also predicts autism-like trait scores from questionnaires and autism symptom severity. Thus, neural activations produced while thinking about other people’s mental states predict variance in multiple indices of social functioning in the real world.
Genetic erosion reduces biomass temporal stability in wild fish populations
Authors: Prunier Jérôme G. , Chevalier Mathieu , Raffard Allan , Loot Géraldine , Poulet Nicolas , Blanchet Simon 
Published: July 2023

AbstractGenetic diversity sustains species adaptation. However, it may also support key ecosystems functions and services, for example biomass production, that can be altered by the worldwide loss of genetic diversity. Despite extensive experimental evidence, there have been few attempts to empirically test whether genetic diversity actually promotes biomass and biomass stability in wild populations. Here, using long-term demographic wild fish data from two large river basins in southwestern France, we demonstrate through causal modeling analyses that populations with high genetic diversity do not reach higher biomasses than populations with low genetic diversity. Nonetheless, populations with high genetic diversity have much more stable biomasses over recent decades than populations having suffered from genetic erosion, which has implications for the provision of ecosystem services and the risk of population extinction. Our results strengthen the importance of adopting prominent environmental policies to conserve this important biodiversity facet.
The burden of osteoarthritis due to high Body Mass Index in Iran from 1990 to 2019
Authors: Darbandi Mitra , Shadmani Fatemeh Khosravi , Miryan Mahsa , Ghalandari Mojtaba , Mohebi Mahsa , Jam Samira Arbabi , Pasdar Yahya 
Published: July 2023

AbstractHigh BMI related burden of knee and hip osteoarthritis (OA) is on a significant rise worldwide. OA not only causes joint pain and stiffness, but it also leads to disability. This study investigated the trend and burden of OA attributable to high body mass index (BMI) in Iran. The age-standardized disability-adjusted life years (DALYs) rates of knee and hip OA due to high BMI, were estimated using data from the Global Burden of Disease 2019. We evaluated DALYs rate trend of high BMI related OA by sex and age in span of 30 years from 1990–2019 across the 31 provinces of Iran. The age-standardized prevalence trend of OA in the knee and hip showed an increase from 1990 to 2019. In 2019 there were 29.92 (95% CI: 10.98–64.92) and 42.50 (95% CI: 16.32–97.37) DALYs/100,000 related to OA from high BMI in men and women, respectively. 2019 saw the greatest DALYs/100,000 rate in the 65–79 age group. From 2005 to 2019, men and women saw DALYs/100,000 rate changes of 24.87 and 17.43 percent, respectively. The burden of knee OA was significantly higher than that of hip OA. DALYs rate of OA due to high BMI was found to be positively associated with the Socio-demographic Index (SDI). The burden of knee and hip OA due to high BMI has increased significantly in recent years in Iran among all age groups of both men and women. It is recommended that health policymakers develop weight control strategies to reduce the burden of OA and implement them at the national level.
Probing of three-dimensional spin textures in multilayers by field dependent X-ray resonant magnetic scattering
Authors: Burgos-Parra Erick , Sassi Yanis , Legrand William , Ajejas Fernando , Léveillé Cyril , Gargiani Pierluigi , Valvidares Manuel , Reyren Nicolas , Cros Vincent , Jaouen Nicolas , Flewett Samuel 
Published: July 2023

AbstractIn multilayers of magnetic thin films with perpendicular anisotropy, domain walls can take on hybrid configurations in the vertical direction which minimize the domain wall energy, with Néel walls in the top or bottom layers and Bloch walls in some central layers. These types of textures are theoretically predicted, but their observation has remained challenging until recently, with only a few techniques capable of realizing a three dimensional characterization of their magnetization distribution. Here we perform a field dependent X-ray resonant magnetic scattering measurements on magnetic multilayers exploiting circular dichroism contrast to investigate such structures. Using a combination of micromagnetic and X-ray resonant magnetic scattering simulations along with our experimental results, we characterize the three-dimensional magnetic texture of domain walls, notably the thickness resolved characterization of the size and position of the Bloch part in hybrid walls. We also take a step in advancing the resonant scattering methodology by using measurements performed off the multilayer Bragg angle in order to calibrate the effective absorption of the X-rays, and permitting a quantitative evaluation of the out of plane (z) structure of our samples. Beyond hybrid domain walls, this approach can be used to characterize other periodic chiral structures such as skyrmions, antiskyrmions or even magnetic bobbers or hopfions, in both static and dynamic experiments.
Differences in proteome perturbations caused by the Wolbachia strain wAu suggest multiple mechanisms of Wolbachia-mediated antiviral activity
Authors: Rainey Stephanie M. , Geoghegan Vincent , Lefteri Daniella A. , Ant Thomas H. , Martinez Julien , McNamara Cameron J. , Kamel Wael , de Laurent Zaydah Rolande , Castello Alfredo , Sinkins Steven P. 
Published: July 2023

AbstractSome strains of the inherited bacterium Wolbachia have been shown to be effective at reducing the transmission of dengue virus (DENV) and other RNA viruses by Aedes aegypti in both laboratory and field settings and are being deployed for DENV control. The degree of virus inhibition varies between Wolbachia strains. Density and tissue tropism can contribute to these differences but there are also indications that this is not the only factor involved: for example, strains wAu and wAlbA are maintained at similar intracellular densities but only wAu produces strong DENV inhibition. We previously reported perturbations in lipid transport dynamics, including sequestration of cholesterol in lipid droplets, with strains wMel/wMelPop in Ae. aegypti. To further investigate the cellular basis underlying these differences, proteomic analysis of midguts was carried out on Ae. aegypti lines carrying strains wAu and wAlbA: with the hypothesis that differences in perturbations may underline Wolbachia-mediated antiviral activity. Surprisingly, wAu-carrying midguts not only showed distinct proteome perturbations when compared to non-Wolbachia carrying and wAlbA-carrying midguts but also wMel-carrying midguts. There are changes in RNA processing pathways and upregulation of a specific set of RNA-binding proteins in the wAu-carrying line, including genes with known antiviral activity. Lipid transport and metabolism proteome changes also differ between strains, and we show that strain wAu does not produce the same cholesterol sequestration phenotype as wMel. Moreover, in contrast to wMel, wAu antiviral activity was not rescued by cyclodextrin treatment. Together these results suggest that wAu could show unique features in its inhibition of arboviruses compared to previously characterized Wolbachia strains.
Bleeding with intensive versus guideline antiplatelet therapy in acute cerebral ischaemia
Authors: Woodhouse Lisa J. , Appleton Jason P. , Christensen Hanne , Dineen Rob A. , England Timothy J. , James Marilyn , Krishnan Kailash , Montgomery Alan A. , Ranta Anna , Robinson Thompson G. , Sprigg Nikola , Bath Philip M. 
Published: July 2023

AbstractIntensive antiplatelet therapy did not reduce recurrent stroke/transient ischaemic attack (TIA) events as compared with guideline treatment in the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial, but did increase the frequency and severity of bleeding. In this pre-specified analysis, we investigated predictors of bleeding and the association of bleeding with outcome. TARDIS was an international prospective randomised open-label blinded-endpoint trial in participants with ischaemic stroke or TIA within 48 h of onset. Participants were randomised to 30 days of intensive antiplatelet therapy (aspirin, clopidogrel, dipyridamole) or guideline-based therapy (either clopidogrel alone or combined aspirin and dipyridamole). Bleeding was defined using the International Society on Thrombosis and Haemostasis five-level ordered categorical scale: fatal, major, moderate, minor, none. Of 3,096 participants, bleeding severity was: fatal 0.4%, major 1.5%, moderate 1.2%, minor 11.4%, none 85.5%. Major/fatal bleeding was increased with intensive as compared with guideline therapy: 39 vs. 17 participants, adjusted hazard ratio 2.21, 95% CI 1.24–3.93, p = 0.007. Bleeding events diverged between treatment groups in the 8–35 day period but not in the 0–7 or 36–90 day epochs. In multivariate analysis more, and more severe, bleeding events were seen with increasing age, female sex, pre-morbid dependency, increased time to randomisation, prior major bleed, prior antiplatelet therapy and in those randomised to triple vs guideline antiplatelet therapy. More severe bleeding was associated with worse clinical outcomes across multiple physical, emotional and quality of life domains.Trial registrationISRCTN47823388.
Preoperative thalamus volume is not associated with preoperative cognitive impairment (preCI) or postoperative cognitive dysfunction (POCD)
Authors: Fislage Marinus , Feinkohl Insa , Borchers Friedrich , Pischon Tobias , Spies Claudia D. , Winterer Georg , Zacharias Norman ,   BioCog Consortium, Wolf Alissa , Müller Anika , Hadzidiakos Daniel , Yürek Fatima , Lachmann Gunnar , Ofosu Kwaku , Heinrich Maria , Mörgeli Rudolf , Gallinat Jürgen , Kühn Simone , Slooter Arjen , van Dellen Edwin , Kant Ilse , de Bresser Jeroen , Hendrikse Jeroen , van Montfort Simone , Menon David , Stamatakis Emmanuel , Preller Jacobus , Moreno-López Laura , Winzeck Stefan , Melillo Daniela , Boraschi Diana , Camera Giacomo Della , Italiani Paola , Schneider Reinhard , Krause Roland , Heidtke Karsten , Nürnberg Peter , Helmschrodt Anja , Böcher Axel , Hafen Bettina , Armbruster Franz Paul , Diehl Ina , Ruppert Jana , Hartmann Katarina , Kronabel Marion , Weyer Marius , Dschietzig Thomas Bernd , Pietzsch Malte , Weber Simon , Ittermann Bernd , Fillmer Ariane 
Published: July 2023

AbstractA growing body of literature suggests the important role of the thalamus in cognition and neurodegenerative diseases. This study aims to elucidate whether the preoperative thalamic volume is associated with preoperative cognitive impairment (preCI) and whether it is predictive for postoperative cognitive dysfunction at 3 months (POCD). We enrolled 301 patients aged 65 or older and without signs of dementia who were undergoing elective surgery. Magnetic resonance imaging was conducted prior to surgery. Freesurfer (version 5.3.) was used to automatically segment the thalamus volume. A neuropsychological test battery was administered before surgery and at a 3 month follow-up. It included the computerized tests Paired Associate Learning (PAL), Verbal Recognition Memory (VRM), Spatial Span Length (SSP), Simple Reaction Time (SRT), the pen-and-paper Trail-Making-Test (TMT) and the manual Grooved Pegboard Test (GPT). Using a reliable change index, preCI and POCD were defined as total Z-score > 1.96 (sum score over all tests) and/or Z-scores > 1.96 in ≥ 2 individual cognitive test parameters. For statistical analyses, multivariable logistic regression models were applied. Age, sex and intracranial volume were covariates in the models. Of 301 patients who received a presurgical neuropsychological testing and MRI, 34 (11.3%) had preCI. 89 patients (29.5%) were lost to follow-up. The remaining 212 patients received a follow-up cognitive test after 3 months, of whom 25 (8.3%) presented with POCD. Independently of age, sex and intracranial volume, neither preCI (OR per cm3 increment 0.81 [95% CI 0.60–1.07] p = 0.14) nor POCD (OR 1.02 per cm3 increment [95% CI 0.75–1.40] p = 0.87) were statistically significantly associated with patients’ preoperative thalamus volume. In this cohort we could not show an association of presurgical thalamus volume with preCI or POCD.Clinical Trial Number: NCT02265263 (https://clinicaltrials.gov/ct2/show/results/NCT02265263).
Eco-friendly simultaneous multi-spectrophotometric estimation of the newly approved drug combination of celecoxib and tramadol hydrochloride tablets in its dosage form
Authors: Ramadan Hesham Sameh , Salam Randa A. Abdel , Hadad Ghada M. , Belal Fathalla , Salim Mohamed M. 
Published: July 2023

AbstractFood and Drug Administration (FDA) recently approved co-formulated celecoxib and tramadol for the treatment of acute pain in adults. Three spectrophotometric methods were efficiently applied to estimate the co-formulated Celecoxib and Tramadol in their tablets; second derivative 2D-spectrophotometry technique (method I), induced dual-wavelength technique (method II) and dual-wavelength resolution technique (method III). The proposed methods were successfully validated following the International Council for Harmonisation (ICH) guidelines and statistically assessed based on the correlation coefficients, relative standard deviations as well as detection and quantitation limits. The obtained results revealed non-significant differences compared to the reported results as revealed by the variance ratio F test and Student t test. Moreover, the applied techniques were further assessed concerning their greenness based on the analytical eco-scale method revealing an excellent green scale with a final score of 95. The proposed spectrophotometric techniques could be applied for the routine analysis and quality control of the studied drugs in their dosage form.
Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice
Authors: Kim June Hee , Han Young-Eun , Oh Soo-Jin , Lee Bonggi , Kwon Obin , Choi Chun Whan , Kim Min Soo 
Published: July 2023

AbstractNeurodegenerative diseases are explained by progressive defects of cognitive function and memory. These defects of cognition and memory dysfunction can be induced by the loss of brain-derived neurotrophic factors (BDNF) signaling. Paeonia lactiflora is a traditionally used medicinal herb in Asian countries and some beneficial effects have been reported, including anti-oxidative, anti-inflammatory, anti-cancer activity, and potential neuroprotective effects recently. In this study, we found that suffruticosol A is a major compound in seeds of Paeonia lactiflora. When treated in a SH-SY5 cell line for measuring cell viability and cell survival, suffruticosol A increased cell viability (at 20 µM) and recovered scopolamine-induced neurodegenerative characteristics in the cells. To further confirm its neural amelioration effects in the animals, suffruticosol A (4 or 15 ng, twice a week) was administered into the third ventricle beside the brain of C57BL/6 mice for one month then the scopolamine was intraperitoneally injected into these mice to induce impairments of cognition and memory before conducting behavioral experiments. Central administration of suffruticosol A into the brain restored the memory and cognition behaviors in mice that received the scopolamine. Consistently, the central treatments of suffruticosol A showed rescued cholinergic deficits and BDNF signaling in the hippocampus of mice. Finally, we measured the long-term potentiation (LTP) in the hippocampal CA3–CA1 synapse to figure out the restoration of the synaptic mechanism of learning and memory. Bath application of suffruticosol A (40 µM) improved LTP impairment induced by scopolamine in hippocampal slices. In conclusion, the central administration of suffruticosol A ameliorated neuronal effects partly through elevated BDNF signaling.