bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of epilepsy with eyelid myoclonia: Results of an international expert consensus panel
Authors: Smith Kelsey M. , Wirrell Elaine C. , Andrade Danielle M. , Choi Hyunmi , Trenité Dorothée Kasteleijn‐Nolst , Jones Hannah , Knupp Kelly G. , Mugar Jon , Nordli Douglas R. , Riva Antonella , Stern John M. , Striano Pasquale , Thiele Elizabeth A. , Zawar Ifrah 
Published: June 2023

AbstractObjectiveThere are limited data about the treatment and management of epilepsy with eyelid myoclonia (EEM). The objective of this study was to determine areas of consensus among an international panel of experts for the management of EEM (formerly known as Jeavons syndrome).MethodsAn international steering committee was convened of physicians and patients/caregivers with expertise in EEM. This committee summarized the current literature and identified an international panel of experts (comprising 25 physicians and five patients/caregivers). This panel participated in a modified Delphi process, including three rounds of surveys to determine areas of consensus for the treatment, other areas of management, and prognosis for EEM.ResultsThere was a strong consensus for valproic acid as the first‐line treatment, with levetiracetam or lamotrigine as preferable alternatives for women of childbearing age. There was a moderate consensus that ethosuximide and clobazam are also efficacious. There was a strong consensus to avoid sodium channel‐blocking medications, except for lamotrigine, as they may worsen seizure control. There was consensus that seizures typically persist into adulthood, with remission occurring in <50% of patients. There was less agreement about other areas of management, including dietary therapy, lens therapy, candidacy for driving, and outcome.SignificanceThis international expert panel identified multiple areas of consensus regarding the optimal management of EEM. These areas of consensus may inform clinical practice to improve the management of EEM. In addition, multiple areas with less agreement were identified, which highlight topics for further research.
Integrated Three‐Dimensional Geological and Numerical Groundwater Model Development
Authors: LeFrancois Michael , Farmer Morgan , Carver Marc 
Published: June 2023

AbstractConceptual site model (CSM) development is a foundational step for numerical groundwater model construction. Tools for reviewing and combining disparate data to develop a CSM have been furthered through software that efficiently integrates multiple data streams, especially when a large amount of information is available at complex sites. Three‐dimensional (3D) interfaces for data visualization and geological modeling are becoming commonly used to compile data, support development of a robust CSM, and create effective visuals that enable project stakeholders to understand site complexity. This article describes a 3D interface workflow applied to a geological and numerical groundwater modeling case study where numerical modeling (i.e., MODFLOW family of codes) was used to assess remedy effectiveness. Specifically, the numerical model was used to overview an in situ solidification (ISS) application, where soil mixing will be conducted with cement, for possible adverse effects to an existing groundwater treatment system. 3D geological modeling allowed for the existing numerical groundwater flow model to be reconstructed to include previously overlooked data on buried infrastructure, which led to a detailed depiction of high‐permeability channels and a more accurate representation of site conditions. Modeling showed that the ISS remedy would not adversely impact the existing groundwater treatment system. Integration of existing data within a 3D interface led to hydrogeological insights that would have been difficult to obtain from two‐dimensional visualization of information, improved numerical modeling efficiency, and informed site remedy decisions. Additionally, the 3D interface created effective visuals that increased internal and external project team conceptual understanding.
Translation, cross‐cultural adaptation, and validation of a Latin American Spanish version of the ID Migraine screening test
Authors: Rodríguez‐Rivas Roberto , Moreno‐Martínez Carlos Alberto , Cerqueira Tiago Lemos , Enríquez‐Peregrino Kevin Giuseppe , Martínez‐Piña Daniel Arturo , Vargas‐Rodríguez Jossy Norilí , Zermeño Fernando 
Published: June 2023

AbstractObjectiveTo translate, culturally adapt, and validate a version of the ID Migraine into Latin American Spanish.BackgroundAlthough still considered a common diagnosis, half of the patients with migraine in Latin America experience diagnostic delay. The ID Migraine is a test developed in 2003 as a valuable tool for the early diagnosis of migraine at the primary care level; however, there is no validated Spanish or culturally adapted version for the Spanish‐speaking population.MethodsThis is an analytical, translation, and test‐validation study. We performed back translation and cross‐cultural adaptation. The Latin American Spanish version ID Migraine MX was applied to headache clinic patients from March 2021 to January 2022 to perform a validation process against the gold standard: blinded expert diagnosis according to the International Classification of Headache Disorders, 3rd edition (ICHD‐3), criteria.ResultsOne hundred seventeen patients from the headache clinic of the National Institute of Neurology and Neurosurgery of Mexico City were screened. We found 62/117 (53%) patients positive for screening with ID Migraine MX, and 47/117 (40%) positive for migraine according to ICHD‐3 criteria. A sensitivity (95% CI) of 0.91 (0.80–0.97), specificity of 0.73 (0.61–0.82), positive predictive value of 0.694 (0.57–0.794), and negative predictive value of 0.93 (0.83–0.97) were obtained. The positive likelihood ratio was 3.38 (2.27–4.99), and the negative likelihood ratio was 0.12 (0.04–0.30). After calling the patients 1 month after the first interview, the calculated Kappa test–retest was 0.75 (p = 0.001).ConclusionA translated and cross‐culturally adapted version into Spanish of the ID Migraine was obtained, with a diagnostic performance similar to the original instrument. Clinicians may use this test at the first level of care to reduce the rate of misdiagnosis and the time from onset of symptoms to diagnosis and treatment of migraine.
Enabling CAR T‐cell therapies for HIV‐positive lymphoma patients – A call for action
Authors: Hattenhauer Sandra Tessa , Mispelbaum Rebekka , Hentrich Marcus , Boesecke Christoph , Monin Malte Benedikt 
Published: June 2023

AbstractPeople living with HIV have a higher risk of developing lymphoma. Outcomes for people living with HIV with relapsed or refractory (r/r) lymphoma remain poor. For this group of patients, chimeric antigen receptor (CAR) T‐cell therapy represents a new successful treatment strategy. However, people living with HIV were not included in pivotal trials, so data are limited to case reports. We searched the PubMed and Ovid technologies databases for literature until 1 November 2022 using the terms ‘HIV and CAR‐T’, ‘HIV and lymphoma’ and ‘HIV and CAR‐T and lymphoma’. Six cases with sufficient information were included in the review. The mean CD4+ T‐cell count before CAR T‐cell therapy was 221 cells/μL (range 52–629). The viral load was below the limit of detection in four patients. All patients had diffuse large B‐cell lymphoma (DLBCL) and were treated with gamma‐retroviral‐based axicabtagene ciloleucel. Four patients developed cytokine‐release syndrome (CRS) grade 2 or less or immune effector‐cell‐associated neurotoxicity syndrome (ICANs) grade 3–4. Four of six patients responded to CAR T‐cell therapy (three complete remissions, one partial remission). In summary, there are no clinical reasons to restrict the use of CAR T‐cell therapy in people living with HIV with r/r DLBCL. According to the current data, CAR T‐cell therapy was safe and effective. In people who meet the standard criteria for CAR T‐cell therapy, this treatment approach could significantly improve the unmet need for more effective treatment options for people living with HIV with r/r lymphoma.
Le travail temporaire, un tremplin vers l'emploi permanent? Nouvel éclairage à partir de données sur le Pérou
Authors: JARAMILLO BAANANTE Miguel , CAMPOS UGAZ Daniela 
Published: June 2023

RésuméLes auteurs cherchent à déterminer dans quelle mesure le travail temporaire fonctionne comme un tremplin vers l'emploi permanent, en distinguant les transitions intra‐entreprises et interentreprises. Pour cela, ils s'appuient sur une base de données employeurs‐salariés recueillies au Pérou sur la période 2012‐2016. Ils proposent plusieurs mesures de ces transitions et estiment des modèles de durée. Ils montrent que seuls 7 pour cent des contrats à durée déterminée sont suivis d'un contrat à durée indéterminée. Ces conversions relèvent d'une mobilité intra‐entreprise dans environ la moitié des cas.
Digital health competencies for the next generation of physicians
Authors: Scott Ian A. , Shaw Tim , Slade Christine , Wan Tai T. , Coorey Craig , Johnson Sandra L. J. , Sullivan Clair M. 
Published: June 2023

AbstractAs health care continues to change and evolve in a digital society, there is an escalating need for physicians who are skilled and enabled to deliver care using digital health technologies, while remaining able to successfully broker the triadic relationship among patients, computers and themselves. The focus needs to remain firmly on how technology can be leveraged and used to support good medical practice and quality health care, particularly around resolution of longstanding challenges in health care delivery, including equitable access in rural and remote areas, closing the gap on health outcomes and experiences for First Nations peoples and better support in aged care and those living with chronic disease and disability. We propose a set of requisite digital health competencies and recommend that the acquisition and evaluation of these competencies become embedded in physician training curricula and continuing professional development programmes.
Profiles of early career insecurity and its outcomes in adolescence: A four‐wave longitudinal study
Authors: Mauno Saija , Klug Katharina , Rantanen Johanna , Muotka Joona , Kiuru Noona 
Published: June 2023

AbstractThis study investigated the developmental profiles of perceived early career insecurity (ECI) and their outcomes among adolescents (n = 1416) during a critical educational transition from basic education to upper secondary education. We found three distinct latent profiles with varying amounts of ECI: Profile 1: Moderate and decreasing ECI before the transition (57%); Profile 2: Low‐decreasing ECI before the transition but increasing ECI after the transition (31%); and Profile 3: High and stable ECI during the transition (12%). Moreover, the ECI profiles related to school and life satisfaction as well as to school stress and dropout intentions in a meaningful way consistent with the stressor hypothesis. Chronically high and increasing ECI was related to negative outcomes.
Strategies elementary school children use to influence mothers' food purchasing decisions
Authors: Monalisa Nazratun N. , Frongillo Edward A. , Blake Christine E. , Steck Susan E. , DiPietro Robin B. 
Published: June 2023

AbstractThis study aimed to understand the strategies elementary‐school‐aged children used to influence mothers' food purchasing decisions. Semi‐structured qualitative interviews were conducted with 40 children aged 6–11 years and their mothers living in South Carolina. Strategies to influence mothers' food purchases were collected from children and their mothers separately. The interviews were audio‐recorded, transcribed verbatim, and open‐coded. The constant comparative method was used for data analysis. Coding matrices were used to compare children's and mothers' responses on the children's strategies. Children reported 157 instances of 25 distinct strategies to influence mothers' purchasing decisions. Mothers had concordance with 83 instances of these strategies. Mothers were more concordant with sons than daughters. The most common and successful strategies reported by children and mothers were repeated polite requests, reasoned requests and referencing friends. Other strategies included offers to contribute money or service, using other family members to pursue mothers for the item, writing a list and grabbing desired items. Mothers perceived that children had a large influence on food purchasing decisions. Children were aware of the strategies that would get positive reactions from mothers. They (children) could get their desired items a lot of times, often, or several times in a month from their mothers irrespective of the healthfulness of the items. Children's influence can be used as a change agent for improving mothers' food purchases if children prefer healthy foods. Efforts are needed for mothers and children to help address children's strategies to influence mothers to purchase unhealthy foods and make healthy foods more appealing to children.
Farewell to humanism? Considerations for nursing philosophy and research in posthuman times
Authors: Petrovskaya Olga 
Published: June 2023

AbstractIn this paper, I argue that critical posthumanism is a crucial tool in nursing philosophy and scholarship. Posthumanism entails a reconsideration of what ‘human’ is and a rejection of the whole tradition founding Western life in the 2500 years of our civilization as narrated in founding texts and embodied in governments, economic formations and everyday life. Through an overview of historical periods, texts and philosophy movements, I problematize humanism, showing how it centres white, heterosexual, able‐bodied Man at the top of a hierarchy of beings, and runs counter to many current aspirations in nursing and other disciplines: decolonization, antiracism, anti‐sexism and Indigenous resurgence. In nursing, the term humanism is often used colloquially to mean kind and humane; yet philosophically, humanism denotes a Western philosophical tradition whose tenets underpin much of nursing scholarship. These underpinnings of Western humanism have increasingly become problematic, especially since the 1960s motivating nurse scholars to engage with antihumanist and, recently, posthumanist theory. However, even current antihumanist nursing arguments manifest deep embeddedness in humanistic methodologies. I show both the problematic underside of humanism and critical posthumanism's usefulness as a tool to fight injustice and examine the materiality of nursing practice. In doing so, I hope to persuade readers not to be afraid of understanding and employing this critical tool in nursing research and scholarship.
A spatial justice perspective on EU rural sustainability as territorial cohesion
Authors: Mahon Marie , Woods Michael , Farrell Maura , Jones Rhys , Goodwin‐Hawkins Bryonny 
Published: June 2023

AbstractTerritorial cohesion is a guiding set of EU principles to achieve sustainable development. However, evidence suggests that within and across rural and peripheral regions in particular, prosperity and social and economic wellbeing continue to lag behind other regions. The aim of this article is to examine how a spatial justice perspective can provide new development insights on rural sustainability. Introducing a spatial justice perspective to a sustainability/territorial cohesion view of rural development, this article explores the scope for alternative framings of rural sustainability based on more place‐based, context‐specific socio‐spatial relations and processes. Drawing on interviews with EU‐based stakeholders mainly representing rural‐based NGOs, it identifies changing values and priorities about rural sustainability linked to notions of spatial justice and fairness. The findings illustrate an evolving local‐level emphasis on rural sustainability as a phenomenon less focused on economic growth and as much on achieving social equity, with associated capacity to frame and agree locally relevant sustainability goals in an inclusive and respectful way.
How Coordinated Capitalism Adapts to the Knowledge Economy: Different Upskilling Strategies in Germany and Switzerland
Authors: Emmenegger Patrick , Bajka Scherwin M. , Ivardi Cecilia 
Published: June 2023

AbstractThe rise of the knowledge economy challenges coordinated models of capitalism by requiring their skill formation systems to produce a workforce with higher skills. This paper examines how coordinated capitalism adapts to upskilling pressures by jointly studying general education and vocational education and training (VET) at both upper‐secondary and tertiary levels. Employing a comparative research design covering German and Swiss upskilling efforts over the past 50 years, we observe important differences. Switzerland, with influential small firms and weak union presence, focuses on keeping VET an attractive option at upper‐secondary level by favoring VET graduates' access to tertiary education. By contrast, Germany, marked by large firm dominance and influential unions, concentrates on expanding general education throughout and adding vocational elements later. Our analysis suggests that firms' reform preferences are conditioned by their size and political constraints to reform.
Sewage sludge treated with bentonite, vermiculite or biochar can improve soil properties and enhance growth of grasses
Authors: Balidakis Athanasios , Matsi Theodora , Karagianni Anastasia‐Garyfallia , Ipsilantis Ioannis 
Published: June 2023

AbstractSewage sludge treated with 15% bentonite, vermiculite or biochar was evaluated as a soil amendment in comparison to limed and untreated sludge. Seven treatments were established to two soils, an acid and an alkaline, in three replications, i.e. 2% addition of sludge treated with bentonite, vermiculite, biochar and lime and application of 2% untreated sludge, inorganic fertilization and no sludge or inorganic fertilizers (control). Then, the soil treatments were used in a pot experiment with perennial ryegrass (Lolium perenne L.) as a test plant. Sludge treated with the clay minerals or biochar improved pH of the acid soil and significantly increased organic matter and available nutrients of both soils compared to control. Although no salinity or sodicity hazard was evidenced, the initial salinity of acid and alkaline soil increased by four‐eight and two‐three times, respectively, upon addition of all sludge treatments, especially that of untreated sludge. Moreover, soil available zinc (Zn) increased by four‐eight times. Soil application of sludge treated with the clay minerals or biochar increased the total aboveground biomass yield of ryegrass in the acid and alkaline soil by 133%–171% and 72%–88%, respectively, compared to control and enhanced nutrient uptake by plants. Furthermore the microbial metabolic quotient indicated lack of low pH and heavy metal stress with addition of sludge to the acid soil. After three harvests of ryegrass, the residual effect of sludge on pH of acid soil and salinity, available phosphorus (P), Zn and boron (B) of both soils still persisted. Thus sewage sludge treated with 15% bentonite, vermiculite or biochar could be applied to soils at a rate of 2% (≈80 Mg ha−1) to serve as soil amendment and fertilizer for grasses and pasture species; however, caution is needed regarding possible P build‐up, Zn phytotoxicity and salinization risks.
Use of CT and MR imaging in radiation therapy planning of imaging‐diagnosed canine intracranial meningioma achieves better tumor coverage than CT alone
Authors: Walther Eric , Warfield Simon , Akbarzadeh Afshin , Davis Karen , Sidhu Narinder , Matthews Quinn , Deveau Michael , Mauldin Neal , Parker Sarah , Mayer Monique 
Published: June 2023

AbstractThe aim of this retrospective, secondary analysis study was to quantify the dosimetric impact of the lack of interobserver agreement on gross tumor volume (GTV) delineation for canine meningioma. This study used a previously reported population of 13 dogs with GTVs contoured on CT alone and on registered CT‐MR by 18 radiation oncologists. The “true” GTV was generated for each dog using a simultaneous truth and performance‐level estimation algorithm, and “true” brain was defined as the whole brain minus true GTV. Treatment plans were generated for each dog and observer combination, using criteria applied to the observer's GTV and brain contours. Plans were then categorized as a pass (met all planning criteria for true GTV and true brain) or fail. A mixed‐effects linear regression was performed to examine differences in metrics between CT and CT‐MR plans and mixed‐effects logistic regression was performed to examine differences in percentages of pass/fail between CT and CT‐MRI plans. The mean percent coverage of true GTV by prescribed dose was higher for CT‐MR plans than for CT plans (mean difference 5.9%; 95% CI, 3.7–8.0; P < 0.001). There was no difference in the mean volume of true brain receiving ≥24 Gy and in maximum true brain dose between CT plans and CT‐MR plans (P ≥ 0.198). CT‐MR plans were significantly more likely to pass the criteria for true GTV and true brain than CT plans (OR 1.75; 95% CI, 1.02–3.01; P = 0.044). This study demonstrated significant dosimetric impact when GTV contouring was performed on CT alone compared with CT‐MR.
Cost-effectiveness of endovascular therapy for acute ischemic stroke with large infarct in China
Authors: Pan Yuesong , Huo Xiaochuan , Jin Aoming , Nguyen Thanh N , Ma Gaoting , Tong Xu , Zhang Xuelei , Gao Feng , Ma Ning , Mo Dapeng , Ren Zeguang , Wang Yongjun , Miao Zhongrong 
Published: June 2023

BackgroundEndovascular therapy administered within 24 hours has been shown to improve outcomes for patients with acute ischemic stroke with large infarction, but the data on its cost-effectiveness are limited.ObjectiveTo evaluate the cost-effectiveness of endovascular therapy for acute ischemic stroke with large infarction in China, the largest low- and middle-income country.MethodsA short-term decision tree model and a long-term Markov model were used to analyze the cost-effectiveness of endovascular therapy for patients with acute ischemic stroke with large infarction. Outcomes, transition probability, and cost data were obtained from a recent clinical trial and published literature. The benefit of endovascular therapy was assessed by the cost per quality-adjusted life-years (QALYs) gained in the short and long term. Deterministic one-way and probabilistic sensitivity analyses were performed to assess the robustness of the results.ResultsCompared with medical management alone, endovascular therapy for acute ischemic stroke with large infarction was found to be cost-effective from the fourth year onward and during a lifetime. In the long term, endovascular therapy yielded a lifetime gain of 1.33 QALYs at an additional cost of ¥73 900 (US$ 11 400), resulting in an incremental cost of ¥55 500 (US$ 8530) per QALY gained. Probabilistic sensitivity analysis showed that endovascular therapy was cost-effective in 99.5% of the simulation runs at a willingness-to-pay threshold of ¥243 000 (3 × gross domestic product per capita of China in 2021) per QALY gained.ConclusionsEndovascular therapy for acute ischemic stroke with large infarction could be cost-effective in China.