bluuebunny/crossref_metadata_2025_split huggingface dataset:
Did the evidence-based intervention (EBI) programme reduce inappropriate procedures, lessen unwarranted variation or lead to spill-over effects in the National Health Service?
Authors: Glynn Joel , Jones Timothy , Bell Mike , Blazeby Jane , Burton Christopher , Conefrey Carmel , Donovan Jenny L. , Farrar Nicola , Morley Josie , McNair Angus , Owen-Smith Amanda , Rule Ellen , Thornton Gail , Tucker Victoria , Williams Iestyn , Rooshenas Leila , Hollingworth William 
Published: September 2023

Background
Health systems are under pressure to maintain services within limited resources. The Evidence-Based Interventions (EBI) programme published a first list of guidelines in 2019, which aimed to reduce inappropriate use of interventions within the NHS in England, reducing potential harm and optimising the use of limited resources. Seventeen procedures were selected in the first round, published in April 2019.

Methods
We evaluated changes in the trends for each procedure after its inclusion in the EBI’s first list of guidelines using interrupted time series analysis. We explored whether there was any evidence of spill-over effects onto related or substitute procedures, as well as exploring changes in geographical variation following the publication of national guidance.

Results
Most procedures were experiencing downward trends in the years prior to the launch of EBI. We found no evidence of a trend change in any of the 17 procedures following the introduction of the guidance. No evidence of spill-over increases in substitute or related procedures was found. Geographic variation in the number of procedures performed across English CCGs remained at similar levels before and after EBI.

Conclusions
The EBI programme had little success in its aim to further reduce the use of the 17 procedures it deemed inappropriate in all or certain circumstances. Most procedure rates were already decreasing before EBI and all continued with a similar trend afterwards. Geographical variation in the number of procedures remained at a similar level post EBI. De-adoption of inappropriate care is essential in maintaining health systems across the world. However, further research is needed to explore context specific enablers and barriers to effective identification and de-adoption of such inappropriate health care to support future de-adoption endeavours.
Reduced racial disparity in receipt of optimal locoregional treatment for women with early-stage breast cancer
Authors: Nadeem Hasan , Romley John A. , Warren Andersen Shaneda 
Published: September 2023

Introduction
Racial disparities in breast cancer treatment contribute to Black women having the worst breast cancer survival rates in the U.S. We investigated whether differences in receipt of optimal locoregional treatment (OLT), defined as receipt of mastectomy, breast-conserving surgery, or no surgery when contraindicated, existed between Black and White women with early-stage breast cancer from 2008–2018.

Methods
In this retrospective cohort study, data from the Surveillance, Epidemiology, and End Results (SEER) Program Incidence Database was utilized to identify tumor cases from Black and White women aged 20–64 years old with stage I-II breast cancer. Logistic regression analyses were used to evaluate the associations between race and receipt of OLT as well as potential effect modification by tumor characteristics, and year of diagnosis.

Results
Among 177,234 women diagnosed with early-stage breast tumors, disparities in OLT between Black and White women were present from 2008–2010 (2008: 82.1% Black vs. 85.7% White, p<0.001; 2009: 82.1% Black vs. 85.8% White, p<0.001; 2010: 82.2% Black vs. 87.2% White, p<0.001). This disparity was eliminated between 2010–2011 (86.3% Black vs. 87.5% White, p = 0.15), and did not reoccur during the remainder of the study period. From 2010–2011, more Black women received radiation therapy following breast-conserving surgery (43.4% to 48.9%; p = 0.001), which accounted for an overall increased receipt of OLT.

Conclusion
Increased receipt of radiation therapy with breast-conserving surgery appeared to drive a substantial increase in OLT for Black women from 2010–2011 that lasted throughout the study period. Further research on the underlying mechanisms that reduced this disparity is warranted.
Short dual antiplatelet therapy duration after percutaneous coronary intervention in high bleeding risk patients: Systematic review and meta-analysis
Authors: Bainey Kevin R. , Marquis-Gravel Guillaume , MacDonald Blair J. , Bewick David , Yan Andrew , Turgeon Ricky D. 
Published: September 2023

Introduction
Dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) reduces major adverse cardiovascular events (MACE) and stent thrombosis. However, DAPT duration is a concern in high bleeding risk (HBR) patients. We evaluated the effect of short DAPT (1–3 months) compared to standard DAPT (6–12 months) on bleeding and ischemic events in HBR PCI.

Methods
We searched MEDLINE, Embase and CENTRAL up to August 18, 2022. Randomized controlled trials (RCTs) comparing short DAPT (1–3 months) versus standard DAPT in HBR PCI were included. We assessed risk of bias (RoB) using the Cochrane RoB2 tool, and certainty of evidence using GRADE criteria. Outcomes included MACE, all-cause death, stent thrombosis, major bleeding, and the composite of major or clinically-relevant non-major bleeding. We estimated risk ratios (RR) and 95% confidence intervals (CI) using a random-effects model.

Results
From 503 articles, we included five RCTs (n = 7,242) at overall low risk of bias with median follow-up of 12-months. Compared to standard DAPT, short DAPT did not increase MACE (RR 1.02, 95% CI 0.84–1.23), all-cause death (RR 0.92, 95% CI 0.71–1.20) or stent thrombosis (RR 1.47, 95% CI 0.73–2.93). Short DAPT reduced major bleeding (RR 0.34, 95% CI 0.13–0.90) and the composite of major or clinically-relevant non-major bleeding (RR 0.60, 95% CI 0.44–0.81), translating to 21 and 34 fewer events, respectively, per 1000 patients.

Conclusions
In HBR PCI, DAPT for 1–3 months compared to 6–12 months reduced clinically-relevant bleeding events without jeopardizing ischemic risk. Short DAPT should be considered in HBR patients receiving PCI.
Socio-economic differences among low-birthweight infants in Hungary. Results of the Cohort ‘18 –Growing Up in Hungary birth cohort study
Authors: Szabó Laura , Boros Julianna 
Published: September 2023

Background
As Hungary had the fifth-highest rate of low-birthweight (LBW) in the EU27 in 2020, LBW still remains a public health problem for the country.

Objective
Our goal is to examine whether LBW in Hungary is determined by the mothers’ educational attainment, adjusted for other maternal characteristics (SES, health behaviour and psychological status during pregnancy) among mothers who gave birth in 2018–2019 in Hungary.

Methods
Source of data is the first and second wave of the Cohort ‘18 –Growing Up in Hungary longitudinal birth cohort study (n = 8185). It is based on a nationwide representative sample of pregnant women who gave birth between March 2018 and April 2019. All data were self-reported by mothers. We examined the association between maternal educational attainment and the risk of giving birth to an LBW-child (<2500g) by using logistic regression analysis. The highest educational attainment of the mother is measured by a five-value categorical variable (ISCED 97: 0–1; 2; 3C; 3–4; 5–6).

Results
5.9% of women had LBW children. This rate is 18.0% among the lowest educated women with ISCED 97: 0–1; and it is 3.6% among the highest educated women with ISCED 97: 5–6. The adjusted predicted probabilities of LBW for these two groups of women are 13.5%, and 3.4% respectively, adjusted for household income quantiles, Roma ethnic background, residence place, smoking, alcohol consumption, and depression during pregnancy; controlled for mother’s height, age at birth, parity and child’s sex. Compared to women with the lowest level of education, the risk of giving birth to an LBW child decreases by 34.6% for those with the second level of education, by 60.1% for those with the third level of education, by 72.5% for those with the fourth level of education and by 77.2% for those with the highest level of education. Smoking during pregnancy significantly increases the risk of giving birth to an LBW by 54.9%. Being depressed at 7th month of pregnancy decreased the risk of giving birth to an LBW child in our sample by 13.2%, however the relationship is not significant.

Conclusion
Our analysis confirmed that maternal educational attainment has a significant impact on the risk of LBW net of by other maternal SES and health behaviour factors. Nevertheless, even after adjusting for these covariates, inequality in LBW by maternal educational attainment persists.
An alternative approach for the excess lifetime cancer risk and prediction of radiological parameters
Authors: Uyanık Nurten Ayten 
Published: September 2023

Abstract
As one of the most important parameters to express radiation's harmful effects is excess lifetime cancer risk, which is presented in the literature with the empirical relationship, an alternative association was developed for excess lifetime cancer risk in this study. This relationship included radiological risk parameters and the average life expectancy and also does not require a coefficient recommended by organizations. The selected area is Çünür district of Isparta province in Türkiye, which is approximately 12.5 km2. The gamma-ray spectrometry studies were carried out at 270 different points. In this study, the radioactive elements (U, Th, and K) are directly measured on the geological materials (trachyandesite, flysch, limestone, and soil) using a gamma-ray spectrometer device. Maps were created to compare the outcomes of excess lifetime cancer risk determined with the new approach and calculated using the existing relationship in the literature. Also, the calculated radiological risk parameters were mapped to evaluate the study area in general. In addition to these, the relationships between each other radioactive elements and the relationships between the radioactive elements and the radiological risk parameters were investigated.
Effects of CYP2D6 allelic variants on therapy with tamsulosin in patients with benign prostatic hyperplasia
Authors: Abdullaev Skokhrukh P. , Shatokhin Maksim N. , Tuchkova Svetlana N. , Abdullaev Sherzod P. , Teodorovich Oleg V. , Loran Oleg B. , Sychev Dmitry A. 
Published: September 2023

Abstract

Objectives
Tamsulosin is a first-line drug for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Despite its high ratings for efficacy and safety, these parameters may vary due to genetic polymorphisms of CYP2D6 enzyme, which is involved in the metabolism of the drug. This variability may have great impact on the therapy of LUTS associated with BPH and may require an individualized approach to drug selection. The aim of the study was to assess the impact of genetic polymorphisms in CYP2D6 on the efficacy and safety of tamsulosin therapy in patients with LUTS associated with BPH.

Methods
The study included 106 patients with LUTS/BPH (N40 according to ICD-10). All patients received monotherapy with tamsulosin 0.4 mg/day for at least 8 weeks. Depending on the severity of symptoms, all patients were divided into 2 groups based on the IPSS score: the first group of patients had moderate symptoms (n=57), and the second group of patients had severe symptoms (n=49). The results of treatment were assessed using the IPSS questionnaire with determination of quality of life (QoL), transrectal ultrasound of the prostate with determination of prostate volume and postvoid residual urine volume, and uroflowmetry. The carriage of allelic variants of CYP2D6 (*3, *4, *9, *10, and *41) were determined by polymerase chain reaction in all patients.

Results
In patients with moderate symptoms who was classified as «intermediate» metabolizers by CYP2D6, a statistically significant greater reduction in symptoms according to the overall IPSS scale at 8 weeks (p=0.046) and the obstructive symptom subscale starting from 4 weeks of treatment (p<0.05) was shown. Allelic variants of the CYP2D6 gene did not affect the frequency of adverse reactions to tamsulosin.

Conclusions
The results of the study show that in patients with moderate LUTS associated with BPH who are «intermediate» metabolizers by CYP2D6, there is a better therapeutic effect of tamsulosin.
Semiotic rhetoric of gift giving in ancient China
Authors: Zhao Xingzhi , Xue Chen 
Published: September 2023

Abstract
This paper examines the signifying mechanism of gift-giving in ancient China from the perspective of semiotic rhetoric, aiming to answer the question of what can be regarded as li (roughly meaning ceremony, rite, courtesy, or gift) or, in other words, how the social meaning of gifts is constructed in giving semiosis. It describes four dominant rhetorical devices that existed in ritual and non-ritual gift exchanges in ancient China. The ritual gift tended to adopt simile and conceit as its meaning-construction device, becoming a symbolic good beyond ‘thingness’ and thus fulfilling the sociocultural function of ritual. Non-ritual giving activity made use of semiotic metonymy and synecdoche as a strategy of ‘indirectness’ to maintain the relationship between the giver and receiver in daily communications.
The effects of progesterone on the healing of obstetric anal sphincter damage in female rats
Authors: Şenyuva İrem , Acar Duygu Baki , Demirel Hasan Hüseyin , Tunç Ece 
Published: September 2023

Abstract
We aimed to evaluate the effects of postpartum progesterone on obstetric anal sphincter injury (OASI) healing in female rats using an experimental OASI model. Twenty-eight female rats were divided into four groups after birth: sham-30, sham-90, progesterone (P4)-30, and P4-90. Moreover, OASI model was established in all groups. Subsequently, except for the sham groups, medroxyprogesterone acetate (0.15 mg) was intramuscularly injected into the P4 groups. After 30 and 90 days, the rats were euthanized under general anesthesia after recording the data. The anal sphincter region was collected for histopathological examination. Progesterone and thiol/disulfide homeostasis studies were performed on blood samples. No significant differences were observed between the groups regarding the external anal sphincter (EAS), internal anal sphincter (IAS), or connective tissue thickness (p = 0.714, p = 0.135, and p = 0.314, respectively). No statistically significant differences in the total thiol, native thiol, disulfide, and progesterone levels were found between the groups (p = 0.917, p = 0.503, p = 0.361, and p = 0.294, respectively). The endometrial thickness was lower in the P4 groups than in the sham groups (p = 0.031). Postpartum progesterone administration did not affect IAS and EAS or connective tissue thickness or disrupt the thiol–disulfide balance. However, this administration led to endometrial thinning.
The crystal structure of 2-anilino-1,4-naphthoquinone, C10H11NO2
Authors: Elmakki Mohammed A. , Taoana Thato N. , Jacobs Frederick J. F. , Venter Johan A. 
Published: September 2023

Abstract
C10H11NO2, monoclinic, P21/n (no. 14), a = 3.7617(3) Å, b = 12.9267(10) Å, c = 23.4609(17) Å, β = 92.337(3)°, V = 1139.87(15) Å3, Z = 4, R

gt
(F) = 0.0413, wR

ref
(F
2) = 0.1071, T = 100 K.
Research methodology of the zolnik (ash hill) at the Scythian cultural circle hillfort in Chotyniec
Authors: Czopek Sylwester , Tokarczyk Tomasz , Trybała-Zawiślak Katarzyna , Adamik-Proksa Joanna , Burghardt Marcin , Ocadryga-Tokarczyk Ewelina , Rajpold Wojciech 
Published: September 2023

Abstract
The article presents the methodology of archaeological research on the hillfort in Chotyniec in south-eastern Poland. In addition to other elements, the research project included the discovery and examination of an object known as a zolnik. A zolnik is a unique object which functioned as a cult place where rituals took the form of communal feasts. Similar objects can be found among those located in the forest-steppe zone of Eastern Europe, which in the early Iron Age was influenced by the Scythian culture. The research methodology presented in the article deviates significantly from that used so far in relation to the investigation of zolniks. This is due to the focus on identifying the most complete spatial and functional context possible, as well as creating a permanent excavation documentation for further analysis and verification. Particular emphasis was placed on the accuracy and meticulousness of documenting the discoveries, which would not have been possible without the application and implementation of spatial information systems. Due to its innovative nature, the article is also intended to start a discussion about the way in which the proposed change in the methods of zolnik examination translates into greater interpretation possibilities. This applies to both functional and chronological issues, which in turn leads to a fuller knowledge and reconstruction of these objects.
Divergent Population-Specific Effects of Chronic Ethanol Exposure on Excitability and Inhibitory Transmission in Male and Female Rat Central Amygdala
Authors: Crofton Elizabeth J. , O'Buckley Todd K. , Bohnsack John P. , Morrow A. Leslie , Herman Melissa A. 
Published: September 2023

The central nucleus of the amygdala (CeA) is implicated in alcohol use disorder (AUD) and AUD-associated plasticity. The CeA is a primarily GABAergic nucleus that is subdivided into lateral and medial compartments with genetically diverse subpopulations. GABAAreceptors are heteromeric pentamers with subunits conferring distinct physiological characteristics. GABAAreceptor signaling in the CeA has been implicated in ethanol-associated plasticity; however, population-specific changes in inhibitory signaling and subunit expression remain unclear. Here, we combined electrophysiology with single-cell gene expression analysis of population markers and GABAAreceptor subunits to examine population-specific changes in inhibitory control in male and female rats following chronic ethanol exposure. We found that chronic ethanol exposure and withdrawal produced global changes in GABAAreceptor subunit expression at the transcript and protein levels, increased excitability in female CeA neurons, and increased inhibitory synaptic transmission in male CeA neurons. When we examined CeA neurons at the single-cell level we found heterogenous populations, as previously reported. We observed ethanol-induced increases in excitability only in somatostatin neurons in the CeA of females, decreases in excitability only in the protein kinase C delta (PKCd) population in males, and ethanol-induced increases in inhibitory transmission in male PKCd and calbindin 2-expressing CeA neurons. There were no population-specific differences in GABAAreceptor (Gabr) subunits in males but reduced GabrA5 expression in female somatostatin neurons. Collectively, these findings suggest that defined CeA populations display differential ethanol sensitivity in males and females, which may play a role in sex differences in vulnerability to AUD or expression of AUD pathology.SIGNIFICANCE STATEMENTThe CeA is involved in the effects of ethanol in the brain; however, the population-specific changes in CeA activity remain unclear. We used recordings of CeA neuronal activity and single-cell gene expression to examine population-specific changes in inhibitory control in male and female rats following chronic ethanol exposure and found sex- and population-specific effects of chronic ethanol exposure and withdrawal. Specifically, female CeA neurons displayed increased excitability in the somatostatin CeA population, whereas male CeA neurons displayed increased inhibitory control in both PKCd and calbindin populations and decreased excitability in the PKCd population. These findings identify CeA populations that display differential sensitivity to ethanol exposure, which may contribute to sex differences in vulnerability to alcohol use disorder.
ETNOMATEMATIKA GERAKAN TARI KRETEK KUDUS PADA PEMBELAJARAN MATEMATIKA
Authors: Sa’adah Nurus , Haqiqi Arghob Khofya , Malasari Putri Nur 
Published: September 2023

Ethnomathematics plays an important role to support a more meaningful concepts understanding in learning mathematics. The Kudus kretek dance is one of the entomathematics that supports understanding the concept of geometry. This study aims to examine the ethnomathematics of kretek dance which involves mathematical activities in learning mathematics. This research is a qualitative descriptive with an ethnographic approach. Data were collected by interview, documentation, and observation techniques. The results showed that the concept of the 900 angle was obtained through the movements of nampeni, milahi, melembar, mbathil, nggiling, sembahan, mrikso rokok, ngepak, pemasaran; the concept of acute angle is obtained through the movements of ngiteri, melembar, pemasaran; the concept of obtuse angle is obtained through ngayak, sembahan, ngiping, mrikso rokok, ngepak, pemasaran; and the concept of 1800 angle is obtained through a nggiling. The kretek dance is demonstrated in a certain beat accompaniment notation, the concept of two-dimensional geometry is found in the position of the feet of the dancers when they are doing the movement, while the concept of transformational geometry is obtained through twisting movements.
ANALISIS KEMAMPUAN BERPIKIR KRITIS MATEMATIS SISWA DALAM MENYELESAIKAN SOAL BERBASIS AKM
Authors: Anggraini Nora Pika , Siagian Teddy Alfra , Agustinsa Ringki 
Published: September 2023

Penelitian ini bertujuan untuk mengetahui sebaran tingkat kemampuan berpikir kritis matematis dalam menyelesaikan soal berbasis AKM kelas VIII di SMP Negeri 1 Kota Bengkulu. Kemampuan berpikir kritis terdiri dari 4 indikator yaitu: (1) interpretasi, (2) analisis, (3) evaluasi, dan (4) inferensi. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kualitatif. Teknik Pemilihan subjek berdasrkan teknik purposive sampling., dengan subjek yaitu 30 orang siswa kelas VIII SMPN 1 Kota Bengkulu pada semester genap tahun ajaran 2021/2022. Teknik analisis data yang digunakan adalah deskriptif kualitatif. Instrumen yang digunakan adalah instrumen tes dan instrumen wawancara. Hasil penelitian menunjukan bahwa rata-rata kemampuan berpikir kritis matematis dalam menyelesaikan soal berbasis AKM kelas VIII di SMP Negeri 1 Kota Bengkulu adalah 31,42% (rendah). Sebaran tingkat kemampuan berpikir kritis pada setiap kategorinya yaitu: 1) kategori tinggi 1 siswa (3,33% ), 2) kategori sedang ada 2 siswa (6,67%), 3) kategori rendah ada 21 siswa (70%) 4) kategori sangat rendah ada 6 siswa (20%). Jadi dapat disimpulkan bahwa kemampuan berpikir kritis siswa masih rendah.