bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated high fluence photoactivated chromophore for infectious keratitis—corneal cross-linking (PACK-CXL) at the slit lamp: a pilot study
Authors: Olshaker Hagar , Achiron Asaf , Chorny Alexander , Hafezi Farhad , Yahalomi Tal , Kratz Assaf , Tsumi Erez , Lu Nan-Ji , Knyazer Boris 
Published: September 2023

Introduction: Photoactivated Chromophore for Infectious Keratitis-Corneal Cross-Linking (PACK-CXL) has garnered substantial interest among researchers and ophthalmologists due to its high promise as a potential treatment for infectious keratitis. The aim of this study is to evaluate the efficacy and safety of high fluence PACK-CXL, using 10.0 J/cm2 (30 mW/cm2, 5 min, and 33 s) at the slit lamp.Methods: This prospective interventional, nonrandomized cohort study included 20 eyes of 20 patients with bacterial, fungal, or mixed origin keratitis who underwent high fluence PACK-CXL treatment as an adjunct therapy to conventional antimicrobial therapy per American Academy of Ophthalmology treatment guidelines. The re-epithelization time was recorded, and corneal endothelial cell density was counted before and after treatment.Results: The average re-epithelization time was 8.2 ± 2.8 days (range 3–14 days). After PACK-CXL treatment, eight patients (40%) were directly discharged, while the remained patients stayed in the hospital for an average of 5.6 ± 3.5 days. No eyes required keratoplasty. Endothelial cell density counts before and after the PACK-CXL procedure were 2,562.1 ± 397.3, and 2,564.8 ± 404.5 cells/mm2, respectively (p = 0.96).Conclusion: although it was not a randomized control trial, we conclude that high fluence PACK-CXL as an adjuvant therapy is safe with no complications observed, and efficient as time to re-epithelization was less than 14 days for all patients and no patients underwent tectonic keratoplasties. Further research is needed to compare it to the current standard of care.
Drug repurposing for Alzheimer’s disease from 2012–2022—a 10-year literature review
Authors: Grabowska Monika E. , Huang Annabelle , Wen Zhexing , Li Bingshan , Wei Wei-Qi 
Published: September 2023

Background: Alzheimer’s disease (AD) is a debilitating neurodegenerative condition with few treatment options available. Drug repurposing studies have sought to identify existing drugs that could be repositioned to treat AD; however, the effectiveness of drug repurposing for AD remains unclear. This review systematically analyzes the progress made in drug repurposing for AD throughout the last decade, summarizing the suggested drug candidates and analyzing changes in the repurposing strategies used over time. We also examine the different types of data that have been leveraged to validate suggested drug repurposing candidates for AD, which to our knowledge has not been previous investigated, although this information may be especially useful in appraising the potential of suggested drug repurposing candidates. We ultimately hope to gain insight into the suggested drugs representing the most promising repurposing candidates for AD.Methods: We queried the PubMed database for AD drug repurposing studies published between 2012 and 2022. 124 articles were reviewed. We used RxNorm to standardize drug names across the reviewed studies, map drugs to their constituent ingredients, and identify prescribable drugs. We used the Anatomical Therapeutic Chemical (ATC) Classification System to group drugs.Results: 573 unique drugs were proposed for repurposing in AD over the last 10 years. These suggested repurposing candidates included drugs acting on the nervous system (17%), antineoplastic and immunomodulating agents (16%), and drugs acting on the cardiovascular system (12%). Clozapine, a second-generation antipsychotic medication, was the most frequently suggested repurposing candidate (N = 6). 61% (76/124) of the reviewed studies performed a validation, yet only 4% (5/124) used real-world data for validation.Conclusion: A large number of potential drug repurposing candidates for AD has accumulated over the last decade. However, among these drugs, no single drug has emerged as the top candidate, making it difficult to establish research priorities. Validation of drug repurposing hypotheses is inconsistently performed, and real-world data has been critically underutilized for validation. Given the urgent need for new AD therapies, the utility of real-world data in accelerating identification of high-priority candidates for AD repurposing warrants further investigation.
Pharmacokinetics and safety of highly variable valsartan in single-pill combination with amlodipine versus its generic formulation: a randomized, three-cycle, three-sequence, partially replicated crossover phase I bioequivalence clinical trial
Authors: Qiu Bo , Song Haojing , Ding Congyang , Sun Xue , Du Runxuan , Yang Haotian , Bai Wanjun , Dong Zhanjun 
Published: September 2023

Valsartan/amlodipine (I) is a single-pill combination (SPC) of an angiotensin II receptor blocker (ARB) and a calcium channel blocker (CCB) for treating hypertension. A clinical trial was performed to demonstrate that the test and reference valsartan/amlodipine formulations were bioequivalent under fasting and postprandial conditions. Participants were randomly divided into three sequences at a ratio of 1:1:1 for three-cycle, reference formulation replicated, crossover administration. The average bioequivalence (ABE) and reference-scaled average bioequivalence (RSABE) methods were used to evaluate BE using the main pharmacokinetic (PK) parameters. Overall, 45 eligible participants were enrolled in the postprandial trial, which was consistent with the fasting trial. For valsartan, the RSABE method was used to evaluate the BE of Cmax, while the ABE method was applied to evaluate the BE of AUC0–t and AUC0–∞. Both point estimates and 95% upper confidence bound met the BE criteria. For amlodipine, the ABE method was performed, and the 90% confidence intervals of the geometric mean ratios (GMR) for Cmax and AUC0–72 h were all within 80%–125%, with the BE criteria being met. Therefore, the two formulations are bioequivalent and have similar safety profiles in healthy Chinese subjects.Clinical trial registration: [http://www.chinadrugtrials.org.cn/index.html], identifier [CTR20210214].
The effects of high-intensity interval training at the anaerobic and psychomotor fatigue thresholds on physiological parameters in young soccer players: a prospective study
Authors: Chmura Paweł , Chmura Jan , Chodor Wiktor , Drożdżowski Adrian , Rokita Andrzej , Konefał Marek 
Published: September 2023

This study aimed to investigate the effects of a 4-week specific high-intensity interval training (HIIT) program performed between the anaerobic threshold (ANT) and the psychomotor fatigue threshold (PFT) on physiological parameters in 14 professional soccer players at the under-17 level. The first and second stages of the research protocol included a treadmill running exercise with increasing load and six 3-min four-versus-four games of soccer with a 3-min break between games. Players then participated in a training microcycle involving three specific HIIT exercises twice per week for 4 weeks, after which they repeated stages one and two, followed by an assessment of changes. The measurement of lactate (LA) determined ANT, whereas the choice reaction time (CRT) indicated PFT among other selected physiological parameters. The repeated-measure analysis of variance (ANOVA) compared mean values for the examined variables using Bonferroni post hoc test. It demonstrated significantly increased maximal oxygen consumption (VO2 max) from 45.9 ± 3.0 to 48.7 ± 2.6 at the ANT and from 49.1 ± 3.4 to 52.0 ± 3.6 on the PFT after 4 weeks of training. A significant increase in the running speed (RS) at both thresholds and heart rate (HR) at the ANT (p ≤ 0.05) was also recorded. Moreover, the players exceeded their intensity of effort during ANT while playing four-versus-four soccer matches, but they did not reach intensity during PFT. In conclusion, the findings of the study demonstrated that both thresholds shifted toward higher loads and the proposed specific HIIT effectively increased the exercise capacity of soccer players.
A two-step inverse solution for a single dipole cardiac source
Authors: Ondrusova Beata , Tino Peter , Svehlikova Jana 
Published: September 2023

Introduction: The inverse problem of electrocardiography noninvasively localizes the origin of undesired cardiac activity, such as a premature ventricular contraction (PVC), from potential recordings from multiple torso electrodes. However, the optimal number and placement of electrodes for an accurate solution of the inverse problem remain undetermined. This study presents a two-step inverse solution for a single dipole cardiac source, which investigates the significance of the torso electrodes on a patient-specific level. Furthermore, the impact of the significant electrodes on the accuracy of the inverse solution is studied.Methods: Body surface potential recordings from 128 electrodes of 13 patients with PVCs and their corresponding homogeneous and inhomogeneous torso models were used. The inverse problem using a single dipole was solved in two steps: First, using information from all electrodes, and second, using a subset of electrodes sorted in descending order according to their significance estimated by a greedy algorithm. The significance of electrodes was computed for three criteria derived from the singular values of the transfer matrix that correspond to the inversely estimated origin of the PVC computed in the first step. The localization error (LE) was computed as the Euclidean distance between the ground truth and the inversely estimated origin of the PVC. The LE obtained using the 32 and 64 most significant electrodes was compared to the LE obtained when all 128 electrodes were used for the inverse solution.Results: The average LE calculated for both torso models and using all 128 electrodes was 28.8 ± 11.9 mm. For the three tested criteria, the average LEs were 32.6 ± 19.9 mm, 29.6 ± 14.7 mm, and 28.8 ± 14.5 mm when 32 electrodes were used. When 64 electrodes were used, the average LEs were 30.1 ± 16.8 mm, 29.4 ± 12.0 mm, and 29.5 ± 12.6 mm.Conclusion: The study found inter-patient variability in the significance of torso electrodes and demonstrated that an accurate localization by the inverse solution with a single dipole could be achieved using a carefully selected reduced number of electrodes.
Clinically elevated depression scores do not produce negative attentional biases in caregivers of autistic children
Authors: Lovell Brian , McCarty Kris , Penfold Phoebe , Wetherell Mark A. 
Published: September 2023

ObjectiveDepression scores in caregivers of autistic children often fall in the clinical range. The attention of clinically depressed individuals tends to be biased toward negatively toned information. Whether caring for an autistic child might also be characterized by a negative attentional bias was explored here.MethodsA sample of N = 98 (57 caregivers and 41 controls) completed questionnaires assessing depressive symptoms. Orienting attention to (i.e., vigilance), and shifting attention away from (i.e., disengagement), negative information was assessed via an online version of the emotional face dot probe task.ResultsMean depression scores in caregivers, falling in the borderline clinical range, were significantly higher compared with controls. Groups, however, were indistinguishable with respect to vigilance and disengagement, and these attentional indices were unrelated to depression scores.ConclusionCaring for an autistic child, while associated with borderline clinical depression scores, was not characterized by a negative attentional bias. Findings are discussed in the context of methodological shortcomings and recommendations for future research.
Exploring factors influencing domestic violence: a comprehensive study on intrafamily dynamics
Authors: Lanchimba Cintya , Díaz-Sánchez Juan Pablo , Velasco Franklin 
Published: September 2023

IntroductionThis econometric analysis investigates the nexus between household factors and domestic violence. By considering diverse variables encompassing mood, depression, health consciousness, social media engagement, household chores, density, and religious affiliation, the study aims to comprehend the underlying dynamics influencing domestic violence.MethodsEmploying econometric techniques, this study examined a range of household-related variables for their potential associations with levels of violence within households. Data on mood, depression, health consciousness, social media usage, household chores, density, and religious affiliation were collected and subjected to rigorous statistical analysis.ResultsThe findings of this study unveil notable relationships between the aforementioned variables and levels of violence within households. Positive mood emerges as a mitigating factor, displaying a negative correlation with violence. Conversely, depression positively correlates with violence, indicating an elevated propensity for conflict. Increased health consciousness is linked with diminished violence, while engagement with social media demonstrates a moderating influence. Reduction in the time allocated to household chores corresponds with lower violence levels. Household density, however, exhibits a positive association with violence. The effects of religious affiliation on violence manifest diversely, contingent upon household position and gender.DiscussionThe outcomes of this research offer critical insights for policymakers and practitioners working on formulating strategies for preventing and intervening in instances of domestic violence. The findings emphasize the importance of considering various household factors when designing effective interventions. Strategies to bolster positive mood, alleviate depression, encourage health consciousness, and regulate social media use could potentially contribute to reducing domestic violence. Additionally, the nuanced role of religious affiliation underscores the need for tailored approaches based on household dynamics, positioning, and gender.
Psychological well-being and associated factors among parents of adolescents with non-suicidal self-injury: a cross-sectional study
Authors: Xia Qian , Zhang Yan , Huang Xuehua 
Published: September 2023

BackgroundNon-suicidal self-injury (NSSI) impacts not only adolescents who engage in it but also their parents. However, there has been limited research into the psychological well-being of these parents. This cross-sectional study aims to investigate the symptoms of anxiety and depression among parents of adolescents who engaged in NSSI in China and the factors associated with them.MethodsA total of 400 parents of adolescents with NSSI were included. Socio-demographic information of these parents was collected. The Generalized Anxiety Disorder 7-item (GAD-7), the Patient Health Questionnaire 9-item (PHQ-9), and the Connor-Davidson Resilience Scale (CD-RISC) were used to assess symptoms of anxiety, depression, and psychological resilience, respectively.ResultsThe majority of the parents were female (83.5%), married (86.3%), and had a senior high school or equivalent and lower education level (67.1%). The study found that 35.3% of the parents experienced clinically significant symptoms of anxiety (GAD-7 ≥ 7) and 40.1% had clinically significant symptoms of depression (PHQ-9 ≥ 7). Parents with larger ages and lower levels of psychological resilience were more likely to experience symptoms of anxiety and depression (p &lt; 0.05). Parents who reported bad parent–child relationships showed a higher level of anxiety.ConclusionThis study provides important insights into the symptoms of anxiety and depression among parents of adolescents with NSSI. Parental age, parent–child relationship, and psychological resilience were associated with symptoms of anxiety and depression in these parents. Implications for the development of interventions aimed at addressing symptoms of anxiety and depression in parents of adolescents with NSSI were discussed.
Projecting the burden of dental caries and periodontal diseases among the adult population in the United Kingdom using a multi-state population model
Authors: Elamin Amal , Ansah John P. 
Published: September 2023

ObjectivesWith the aging United Kingdom population, oral diseases are expected to increase. Exploring credible projections is fundamental to understanding the likely impact of emerging population-level interventions on oral disease burden. This study aims at providing a credible, evidence-based projection of the adult population in the United Kingdom with dental caries and periodontal diseases.MethodsWe developed a multi-state population model using system dynamics that disaggregates the adult population in the United Kingdom into different oral health states. The caries population was divided into three states: no caries, treated caries, and untreated caries. The periodontal disease population was disaggregated into no periodontal disease, pocketing between 4 and &lt; 6 mm, 6 and &lt; 9 mm, and 9 mm or more. Data from the 2009 dental health survey in the United Kingdom was used to estimate age and gender-specific prevalence rates as input to the multi-state population model.ResultsOf the population 16 years and older, the number with carious teeth is projected to decrease from 15.742 million in the year 2020 to 15.504 million by the year 2050, representing a decrease of 1.5%. For individuals with carious teeth, the older adult population is estimated to constitute 62.06% by 2050 and is projected to increase 89.4% from 5.079 million in 2020 to 9.623 million by 2050. The adult population with periodontal pocketing is estimated to increase from 25.751 million in 2020 to 27.980 million by 2050, while those with periodontal loss of attachment are projected to increase from 18.667 million in 2020 to 20.898 million by 2050. The burden of carious teeth and periodontal diseases is anticipated to shift from the adult population (16–59 years) to the older adult population. The older adult population with carious teeth is estimated to rise from 32.26% in 2020 to 62.06% by 2050, while that for periodontal disease is expected to increase from 42.44% in 2020 to 54.57% by 2050.ConclusionThis model provides evidence-based plausible future demand for oral health conditions, allowing policymakers to plan for oral health capacity to address growing needs. Because of the significant delay involved in educating and training oral health personnel, such projections offer policymakers the opportunity to be proactive in planning for future capacity needs instead of being reactive.
Investigating the effectiveness of protection motivation theory in predicting behaviors relating to natural disasters, in the households of southern Iran
Authors: Faryabi Reza , Rezabeigi Davarani Fatemeh , Daneshi Salman , Moran Declan Patrick 
Published: September 2023

BackgroundDisasters can lead to large human casualties, destruction of property and economic and environmental resources. The purpose of the present study was to answer the question whether the Protection Motivation Theory (PMT) is effective in predicting behaviors related to the harmful effects of natural disasters in the households of southern Iran.Materials and methodsThis quantitative and cross-sectional study was conducted on 528 households in Jiroft city. Sampling was done by combined method (the combination of cluster, simple random, proportional and systematic random sampling). A total of 528 households were included. The tools for collecting data were demographic information and a researcher-made questionnaire related to PMT constructs and preventive behaviors from the harmful effects of natural disasters. Data was analyzed using SPSS v21 software, and the necessary analyzes (descriptive tests, chi-square, one-way ANOVA and Pearson’s correlation test) were performed at a significance level of 0.05. Using Amos v 21 software, the predictors of safety behaviors were determined using path analysis.ResultsThe results showed 51.7% lived in the city and 62.1% of residential buildings were of brick without markings. There is a significant difference between preventive behaviors and direct exposure to disasters (p &lt; 0.001), education (p = 0.004), monthly income (p = 0.004) and source of information (p = 0.040). There was also a significant correlation between preventive behaviors and the number of vulnerable family members (p = 0.001, r = 0.160). The adjusted model of the path analysis test showed that protection motivation (β = 0.547), fear (β = 0.147) and perceived vulnerability (β = 0.135) had the greatest role among the constructs of the protection motivation theory.ConclusionAccording to the results of the study, it is suggested that health planners design and implement educational interventions based on the structures of the mentioned model to increase the preparedness of households against natural disasters.
To vaccinate or to isolate? Establishing which intervention leads to measurable mortality reduction during the COVID-19 Delta wave in Poland
Authors: Walkowiak Marcin Piotr , Walkowiak Dariusz , Walkowiak Jarosław 
Published: September 2023

BackgroundDuring the Delta variant COVID-19 wave in Poland there were serious regional differences in vaccination rates and discrepancies in the enforcement of pandemic preventive measures, which allowed us to assess the relative effectiveness of the policies implemented.MethodsCreating a model that would predict mortality based on vaccination rates among the most vulnerable groups and the timing of the wave peak enabled us to calculate to what extent flattening the curve reduced mortality. Subsequently, a model was created to assess which preventive measures delayed the peak of infection waves. Combining those two models allowed us to estimate the relative effectiveness of those measures.ResultsFlattening the infection curve worked: according to our model, each week of postponing the peak of the wave reduced excess deaths by 1.79%. Saving a single life during the Delta wave required one of the following: either the vaccination of 57 high-risk people, or 1,258 low-risk people to build herd immunity, or the isolation of 334 infected individuals for a cumulative period of 10.1 years, or finally quarantining 782 contacts for a cumulative period of 19.3 years.ConclusionsExcept for the most disciplined societies, vaccination of high-risk individuals followed by vaccinating low-risk groups should have been the top priority instead of relying on isolation and quarantine measures which can incur disproportionately higher social costs. Our study demonstrates that even in a country with uniform policies, implementation outcomes varied, highlighting the importance of fine-tuning policies to regional specificity.