bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONTRIBUIÇÃO DE WITTGENSTEIN PARA O DEBATE SOBRE O CETICISMO
Authors: Armendane Geraldo das Dôres de 
Published: June 2023

RESUMO: Este artigo discute a contribuição do segundo Wittgenstein para o debate sobre o ceticismo metodológico de Descartes. Esse tipo de ceticismo é formado por um conjunto de argumentos céticos, a saber: os argumentos da Ilusão dos sentido, do Sonho, do Deus enganador ou do Gênio maligno, presentes na primeira meditação das Meditações Metafísicas. Demostraremos que o projeto terapêutico da filosofia do segundo Wittgenstein constitui uma proposta interessante para o enfrentamento do ceticismo na filosofia contemporânea. Para isso, em primeiro lugar, abordaremos as críticas de Wittgenstein ao ceticismo filosófico em suas três obras, a saber, Tractatus Logico-philosophicus, Investigações Filosóficas e Da Certeza; em seguida, mostraremos que a proposta terapêutica do segundo Wittgenstein é relevante para o enfretamento do ceticismo na filosofia contemporânea; e, por fim, apresentaremos a conclusão que chegamos.
PALAVRAS-CHAVE: Ceticismo metodológico, Descartes, terapia da linguagem, segundo Wittgenstein.
A FIGURA DO TESTADURA EM DANTO E A NOÇÃO WITTGENSTEINIANA DE CEGUEIRA PARA ASPECTO
Authors: Gobatto da Silva Marco Aurélio , Donat Mirian 
Published: June 2023

Resumo: As divergências entre a filosofia de Arthur Danto em relação ao pensamento wittgensteiniano, especificamente em sua aplicação no campo da filosofia da arte, são profundas, marcadamente na oposição entre o essencialismo do primeiro e o antiessencialismo do segundo. Entretanto, apesar dessas divergências, há também pontos de convergência entre os dois autores, sobretudo no que diz respeito a uma epistemologia da arte, onde esta confluência se mostra mais nítida. Neste artigo, mostramos que esta convergência pode ser explicitada a partir da figura do Testadura de Danto e da noção de cegueira para aspectos de Wittgenstein.
PALAVRAS-CHAVE: Arte; Epistemologia; Danto; Wittgenstein.
ABSTRACT: The divergences between Arthur Danto's philosophy in relation to Wittgensteinian thought, specifically in its application in the field of philosophy of art, are profound, markedly in the opposition between the essentialism of the first and the anti-essentialism of the second. However, despite these divergences, there are also points of convergence between the two authors, especially with regard to an epistemology of art, where this confluence is clearer. In this article, we show that this convergence can be explained from the figure of Danto's Testadura and Wittgenstein's notion of blindness to aspects.
KEYWORDS: Art; Epistemology; Danto; Wittgenstein.
Scheme to eliminate the time shift of code edges based on the optimal transmission point of a DP-MZM
Authors: Guo Pengfei , Lai Zhi , Zhang Zhenjiang , Fang Xinkuo , Shang Yajie 
Published: June 2023

To eliminate the time shift of code edges on a single-sideband (SSB) modulation signal transmission in a radio-over-fiber (RoF) system, a new, to the best of our knowledge, SSB modulation scheme based on an optimal transmission point for a double-parallel Mach–Zehnder modulator (DP-MZM) is proposed. The scheme is based on DP-MZM to realize the separation of the carrier and the +1st-order sideband at the optimal transmission point, and the baseband signal modulates the 2.5 Gb/s data signal to the +1st-order sideband of the SSB signal; then, the carrier and the +1st-order sideband are transmitted with a carrier-to-sideband ratio of 0 dB. Theoretical analysis shows that compared to the traditional SSB-modulated optical millimeter-wave signal generation scheme this scheme completely solves the problem of the time shift of code edges caused by dispersion. The simulation results show that the improved SSB modulation scheme has a Q factor of 23.362, the minimum bit error rate is 4.207×10−127 at 73.453 km, and the eye diagram is still very clear. Under the premise of meeting the basic requirements of communications, the maximum communications distance can reach 135 km, which is 270% of the transmission distance of a traditional SSB modulation model. Thus, the system performance has been greatly improved.
Broadband frequency modulation signal downconversion using a monolithic integrated mutual injection laser
Authors: Chen Shilin , Pu Tao , Zheng Jilin , Wang Li , Wu Gengze , Li Jin , Zhang Xin 
Published: June 2023

We propose a new, to the best of our knowledge, broadband signal
downconversion scheme implemented by a monolithic integrated mutual
injection laser. A mathematical derivation, simulation, and
experimental verification are carried out. Because the period-one
oscillation frequency can be selectively operated on a large scale by
controlling the current on the integrated laser, the tuning
downconversion range is realized without changing the experimental
equipment. The experiment verifies that the downconversion of the
linear frequency modulation signal with a bandwidth of 0.5 GHz
from the center frequency of 18.75 to 0.85 GHz, and the
spurious-free dynamic range (SFDR) has reached 71.7dB/Hz2/3. Compared with the scheme based on
discrete components, the system has no electric local oscillator or
external modulator, which provides a method for radar signal
downconversion.
Understanding target-specific effects of antidepressant drug pollution on molluscs: A systematic review protocol
Authors: Imiuwa Maurice E. , Baynes Alice , Routledge Edwin J. 
Published: June 2023

Background
The environmental prevalence of widely prescribed human pharmaceuticals that target key evolutionary conserved biomolecules present across phyla is concerning. Antidepressants, one of the most widely consumed pharmaceuticals globally, have been developed to target biomolecules modulating monoaminergic neurotransmission, thus interfering with the endogenous regulation of multiple key neurophysiological processes. Furthermore, rising prescription and consumption rates of antidepressants caused by the burgeoning incidence of depression is consistent with increasing reports of antidepressant detection in aquatic environments worldwide. Consequently, there are growing concerns that long-term exposure to environmental levels of antidepressants may cause adverse drug target-specific effects on non-target aquatic organisms. While these concerns have resulted in a considerable body of research addressing a range of toxicological endpoints, drug target-specific effects of environmental levels of different classes of antidepressants in non-target aquatic organisms remain to be understood. Interestingly, evidence suggests that molluscs may be more vulnerable to the effects of antidepressants than any other animal phylum, making them invaluable in understanding the effects of antidepressants on wildlife. Here, a protocol for the systematic review of literature to understand drug target-specific effects of environmental levels of different classes of antidepressants on aquatic molluscs is described. The study will provide critical insight needed to understand and characterize effects of antidepressants relevant to regulatory risk assessment decision-making, and/or direct future research efforts.

Methods
The systematic review will be conducted in line with the guidelines by the Collaboration for Environmental Evidence (CEE). A literature search on Scopus, Web of Science, PubMed, as well as grey literature databases, will be carried out. Using predefined criteria, study selection, critical appraisal and data extraction will be done by multiple reviewers with a web-based evidence synthesis platform. A narrative synthesis of outcomes of selected studies will be presented. The protocol has been registered in the Open Science Framework (OSF) registry with the registration DOI: 10.17605/OSF.IO/P4H8W.
PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes
Authors: Skjervold Anette H. , Valla Marit , Ytterhus Borgny , Bofin Anna M. 
Published: June 2023

Introduction
P21-activated kinase 1 (PAK1) is known to be overexpressed in several human tumour types, including breast cancer (BC). It is located on chromosome 11 (11q13.5-q14.1) and plays a significant role in proliferation in BC. In this study we aimed to assess PAK1 gene copy number (CN) in primary breast tumours and their corresponding lymph node metastases, and associations between PAK1 CN and proliferation status, molecular subtype, and prognosis. In addition, we aimed to study associations between CNs of PAK1 and CCND1. Both genes are located on the long arm of chromosome 11 (11q13).

Methods
Fluorescence in situ hybridization for PAK1 and Chromosome enumeration probe (CEP)11 were used on tissue microarray sections from a series of 512 BC cases. Copy numbers were estimated by counting the number of fluorescent signals for PAK1 and CEP11 in 20 tumour cell nuclei. Pearson’s x2 test was performed to assess associations between PAK1 CN and tumour features, and between PAK1 and CCND1 CNs. Cumulative risk of death from BC and hazard ratios were estimated in analysis of prognosis.

Results
We found mean PAK1 CN ≥4<6 in 26 (5.1%) tumours, and CN ≥ 6 in 22 (4.3%) tumours. The proportion of cases with copy number increase (mean CN ≥4) was highest among HER2 type and Luminal B (HER2-) tumours. We found an association between PAK1 CN increase, and high proliferation, and high histological grade, but not prognosis. Of cases with PAK1 CN ≥ 6, 30% also had CCND1 CN ≥ 6.

Conclusions
PAK1 copy number increase is associated with high proliferation and high histological grade, but not with prognosis. PAK1 CN increase was most frequent in the HER2 type and Luminal B (HER2-) subtype. PAK1 CN increase is associated with CN increase of CCND1.
Refining the Performance of Routine Information System Management (PRISM) framework for data use at the local level: An integrative review
Authors: Kawakyu Nami , Coe Megan , Wagenaar Bradley H. , Sherr Kenneth , Gimbel Sarah 
Published: June 2023

Introduction
Foundational to a well-functioning health system is a strong routine health information system (RHIS) that informs decisions and actions at all levels of the health system. In the context of decentralization across low- and middle-income countries, RHIS has the promise of supporting sub-national health staff to take data-informed actions to improve health system performance. However, there is wide variation in how “RHIS data use” is defined and measured in the literature, impeding the development and evaluation of interventions that effectively promote RHIS data use.

Methods
An integrative review methodology was used to: (1) synthesize the state of the literature on how RHIS data use in low- and middle-income countries is conceptualized and measured; (2) propose a refined RHIS data use framework and develop a common definition for RHIS data use; and (3) propose improved approaches to measure RHIS data use. Four electronic databases were searched for peer-reviewed articles published between 2009 and 2021 investigating RHIS data use.

Results
A total of 45 articles, including 24 articles measuring RHIS data use, met the inclusion criteria. Less than half of included articles (42%) explicitly defined RHIS data use. There were differences across the literature whether RHIS data tasks such as data analysis preceded or were a part of RHIS data use; there was broad consensus that data-informed decisions and actions were essential steps within the RHIS data use process. Based on the synthesis, the Performance of Routine Information System Management (PRISM) framework was refined to specify the steps of the RHIS data use process.

Conclusion
Conceptualizing RHIS data use as a process that includes data-informed actions emphasizes the importance of actions in improving health system performance. Future studies and implementation strategies should be designed with consideration for the different support needs for each step of the RHIS data use process.
Effects of plantar-sensory treatments on postural control in chronic ankle instability: A systematic review and meta-analysis
Authors: Hu Xiaomei , Liao Jingjing , Hu Xiaoyue , Zeng Ziwei , Wang Lin 
Published: June 2023

Objective
This study aimed to examine the effects of plantar-sensory treatments on postural control in individuals with chronic ankle instability (CAI).

Methods
This study was registered in PROSPERO (registration number CRD42022329985) on May 14, 2022. An extensive search was performed in Pubmed, Embase, Cochrane, Web of Science, and Scopus to identify the potential studies on plantar-sensory treatments affecting postural control before May 2022. The methodological quality of involved studies was assessed using the scale of Physiotherapy Evidence Database (PEDro). The Cochrane Tool and the Risk of Bias in Non-randomized Studies of Interventions assessment tool were used to evaluate the risk of bias in randomised controlled trials (RCTs) and non-RCTs respectively. RevMan 5.4 was utilised to calculate the standardised mean difference (SMD), with 95% confidence interval (CI).

Results
Eight RCTs with a mean PEDro rating of 6 and four non-RCTs with a mean PEDro rating of 4.75 were included in the quantitative analysis. The types of plantar-sensory treatments included plantar massage, whole-body vibration and textured surface-stimulation treatment. A significant effect of static balance with eyes open (SMD = −0.54; 95% CI: −0.81 to −0.27; p < 0.001) was found and subgroup analysis showed that plantar massage (SMD = −0.49; 95% CI: −0.84 to −0.14; p = 0.006) and whole-body vibration (SMD = −0.66; 95% CI: −1.12 to −0.19; p = 0.005) had positive effects. In the subgroup analysis of anterior dynamic balance, whole-body vibration revealed a significant increase (SMD = 0.60; 95% CI: 0.06−1.14; p = 0.03). The pooled results or subgroup analysis including eyes-closed static balance and other directions of dynamic balance indicated no significant difference (p > 0.05).

Conclusions
This meta-analysis indicated that plantar-sensory treatments could improve postural control in CAI, especially the treatments of plantar massage and long-term whole-body vibration.
Lessons learned from the adaptation of the Reflective Functioning Questionnaire (RFQ) for Dutch people with mild to borderline intellectual disabilities
Authors: Derks Suzanne D. M. , Willemen Agnes M. , Vrijmoeth Cis , Sterkenburg Paula S. 
Published: June 2023

Background
People with mild to borderline intellectual disabilities (MBIDs) face challenges in social functioning, possibly as a result of limited mentalising abilities such as reflecting on the behaviour of themselves and others. Reflective functioning in people with MBIDs has not yet been investigated due to a lack of instruments. The Reflective Functioning Questionnaire (RFQ) is a seemingly easy adaptable, short self-report questionnaire. The aim of the present, explorative study was to adapt the RFQ for people with MBIDs and investigate the psychometric properties and correlations with other mentalising related constructs. The formulation of the items was adapted to the target group and items were added to broaden the scope towards reflection on both the self and other.

Method
Participants were 159 adults with MBIDs who completed a Dutch-translated and easy-to-read RFQ with five supplemental items, a questionnaire for autistic traits, a self-report questionnaire assessing perspective taking and two performance-based measures assessing emotion recognition and Theory of Mind.

Results
Confirmatory factor analysis confirmed the factor structure of the RFQ and revealed a two-factor structure with a Self and Other subscale. Generally satisfactory internal consistency and test-retest reliability were found. Explorative results showed correlations of the RFQ-8 and RFQ subscales with autistic traits and between the RFQ Other and perspective taking.

Conclusions
This explorative study is the first testing psychometric properties of the RFQ as a self-report questionnaire for assessing reflective functioning in adults with MBIDs. This step is relevant in gaining more scientific knowledge on assessing mentalising in people with MBIDs.
Freak Scenes: American Indie Cinema and Indie Music Cultures, Sexton Jamie (2023)
Authors: Arnold Gina 
Published: June 2023

Review of: Freak Scenes: American Indie Cinema and Indie Music Cultures, Sexton Jamie (2023)
University of Edinburgh Press, 208 pp.,
ISBN 978-1-47441-408-1, h/bk, £85.00
ISBN 978-1-47441-407-4, e-book, £85.00
Comparative analysis of antioxidant potential in leaf, stem, and root of Paederia foetida L.
Authors: HUSNA Tasnima , MOHI-UD-DIN Mohammed , HASAN Md. Mehedi , NAZRAN Anika , KHAN Haider Iqbal , HASSAN Jahidul , SHOVON Md. Neamul Hasan , GHOSH Totan Kumar 
Published: June 2023

Paederia foetida L. is widely used for the treatment of myriad ailments. Thus, searching for plant parts having greater antioxidant potential would make it easy to get suitable materials for herbal drugs. The present effort was made to explore the antioxidant potentials in the plant parts of P. foetida grown under natural conditions by means of physiological and biochemical analyses. The young leaves showed the highest reservoir of non-enzymatic antioxidants such as chlorophylls (0.96 mg g-1), carotenoids (0.43 mg g-1), anthocyanins (53.99 µg g-1), phenolics (728.24 µg g-1), flavonoids (4178.05 µg g-1), and proline (1.46 µmol g-1) as compared to others. Total antioxidant activity was found to be the highest in young leaves (84.82 %) followed by young stems (80.24 %) and matured leaves (79.78 %). Analysis of enzymatic antioxidants resulted in the superior activity of ascorbate peroxidase (13.58 µmol min-1 mg-1) and glutathione S-transferase (3409 nmol min-1 mg-1) in young leaves whereas the highest rate of catalase (409.85 µmol min-1 mg-1) and peroxidase (3.5 nmol min-1 mg-1) activity were found in matured leaves. However, comparatively higher content of reactive oxygen species; hydrogen peroxide, and lipid peroxidation product; malondialdehyde in matured leaves than that of young leaves suggests that young leaf is a suitable source for herbal medicine.
Study of the behavior of reactive powder concrete RC deep beams by strengthening shear using near-surface mounted CFRP bars
Authors: Azeez Alyaa Abdulrazzaq , Jaafar Azhar Ayad , Yussof Mustafasanie M. , Blash Abrahem A. Ali 
Published: June 2023

AbstractThe applications of modern materials especially reactive powder concrete for improving concrete structures have been significantly growing in recent years. Great conduct properties creep, shrinkage, little permeability, ultra-high strength, and expanded safety against corrosion are the important features of Reactive Powder Concrete. In addition, the use of the Near-Surface Mounted technique in recent decades has helped strengthen and repair shears-reinforced concrete (RC) for deep beams using carbon fiber replacement reinforcing bars. The parameters studied in the present research investigated the impact of the maximum load, deflection, stress–strain curve of concrete, first shear crack, crack pattern, and crack width. Considering the aforesaid cause and objective, one specimen of Reactive Powder Concrete RC deep beams has a rectangular cross-section of 150 mm in width, 500 mm in depth, and a total length of 1.2 m. One control specimen was tested for comparison. In addition, 12 control specimens (cylinder and cubes) are used for experimental investigation on the mechanical properties of normal and Reactive Powder Concrete deep beams. Following the specimens’ processing, they were subjected to one concentrated load pressure test through a hydraulic jack. Moreover, six core drill specimens were taken from those deep beams to obtain the real mechanical properties of those beams, including maximum stress, modulus of elasticity, density, stress–strain curve, and Poisson’s ratio, after subjecting them to the pressure machine. Depending on the results, the ultimate strength, deflection, and first shear crack capacity for the specimens (RPCDB1P-4NSM & RPCDB1P-8NSM) have increased by (21, 25), (47, 27), and (133, 150)%, respectively, compared with (CDB1PC20). Moreover, the specimens above have reduced the first shear crack width by (9, 33.25)% respectively compared with (CDB1PC20) at 65% of the ultimate shear load.
Sensitivity of estimands in clinical trials with imperfect compliance
Authors: Chen Heng , Heitjan Daniel F. 
Published: June 2023

Abstract
In clinical trials that are subject to noncompliance, the commonly used intention-to-treat estimand is valid as a causal effect of treatment assignment but is sensitive to the level of compliance. An alternative estimand, the complier average causal effect (CACE), measures the average effect of treatment received in the latent subset of subjects who would comply with either assigned treatment. Because the principal stratum of compliers can vary with the circumstances of the trial, CACE too depends on the compliance fraction. We propose a model in which an underlying latent proto-compliance interacts with trial characteristics to determine a subject’s compliance behavior. When the latent compliance is independent of the individual treatment effect, the average causal effect is constant across compliance classes, and CACE is robust across trials and equal to the population average causal effect. We demonstrate the potential degree of sensitivity of CACE in a simulation study, an analysis of data from a trial of vitamin A supplementation in children, and a meta-analysis of trials of epidural analgesia in labor.
Organisation as Reflexive Structuration
Authors: Ortmann Günther , Sydow Jörg , Windeler Arnold 
Published: June 2023

Abstract
Our
"Beacons of Organizational Sociology"
series makes available, through first-time translations, texts that have shaped debates in organizational sociology in non-English-speaking countries, or presents reflections on such debates by established scholars. The first text in this series is a shortened English translation of the German article “Organisation als reflexive Strukturation” by Günther Ortmann, Jörg Sydow, and Arnold Windeler, published in 1997 in the highly influential book “Theorien der Organisation. Die Rückkehr der Gesellschaft” [Theories of Organization. The Return of Society]. The article applies Giddens’ social theory to organizational research. In elaborating on “the principle of reflexive organization,” the text provides a social-theoretically informed concept of organization that is of continuing relevance for organization research today. The publication can be classified as one of the decisive writings by the authors contributing to establishing organizational research based on structuration theory in the German-speaking world, informing many studies, e.g., on new organizational forms, innovation, and inter-organizational relations. The concise overview of the various existing studies in organization research using a structuration perspective at that time in the original manuscript is not part of this translation.