bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi‐center study
Authors: Khoo Xin‐Hui , Chong Chun‐Wie , Talha Abdul Malik , Philip Koshy , Teh Cindy Shuan‐Ju , Isa Adib Mat , Wong Mung Seong , Chew Deborah Chia‐Hsin , Wong Zhiqin , Jusoh Nor Syarahani , Maksum Noorhuda Madihah Mohamed , Mokhtar Norfilza Mohd , Majid Hazreen Abdul , Ali Raja Affendi Raja , Lee Yeong‐Yeh , Mahadeva Sanjiv 
Published: March 2023

AbstractBackground and AimThe gut microbiota in irritable bowel syndrome (IBS) is known to vary with diet. We aim to (i) analyze the gut microbiota composition of IBS patients from a multi‐ethnic population and (ii) explore the impact of a low FODMAP diet on gastrointestinal symptoms and gut microbiota composition among IBS patients.MethodsA multi‐center study of multi‐ethnic Asian patients with IBS was conducted in two phases: (i) an initial cross‐sectional gut microbiota composition study of IBS patients and healthy controls, followed by (ii) a single‐arm 6‐week dietary interventional study of the IBS patients alone, exploring clinical and gut microbiota changes.ResultsA total of 34 adult IBS patients (IBS sub‐types of IBS‐D 44.1%, IBS‐C 32.4%, and IBS‐M 23.5%) and 15 healthy controls were recruited. A greater abundance of Parabacteroides species with lower levels of bacterial fermenters and short‐chain fatty acids producers were found among IBS patients compared with healthy controls. Age and ethnicity were found to be associated with gut microbiota composition. Following a low FODMAP dietary intervention, symptom and quality of life improvement were observed in 24 (70.6%) IBS patients. Symptom improvement was associated with adherence to the low FODMAP diet (46.7% poor adherence vs 92.9% good adherence, P = 0.014), and gut microbiota patterns, particularly with a greater abundance of Bifidobacterium longum, Anaerotignum propionicum, and Blautia species post‐intervention.ConclusionGut microbiota variation in multi‐ethnic IBS patients may be related to dietary intake and may be helpful to identify patients who are likely to respond to a low FODMAP diet.
An agonist of CXCR4 induces a rapid recovery from the neurotoxic effects of Vipera ammodytes and Vipera aspis venoms
Authors: Stazi M. , Megighian A. , D'Este G. , Negro S. , Ivanušec A. , Lonati D. , Pirazzini M. , Križaj I. , Montecucco C. 
Published: March 2023

AbstractPeople bitten by Alpine vipers are usually treated with antivenom antisera to prevent the noxious consequences caused by the injected venom. However, this treatment suffers from a number of drawbacks and additional therapies are necessary. The venoms of Vipera ammodytes and of Vipera aspis are neurotoxic and cause muscle paralysis by inducing neurodegeneration of motor axon terminals because they contain a presynaptic acting sPLA2 neurotoxin. We have recently found that any type of damage to motor axons is followed by the expression and activation of the intercellular signaling axis consisting of the CXCR4 receptor present on the membrane of the axon stump and of its ligand, the chemokine CXCL12 released by activated terminal Schwann cells. We show here that also V. ammodytes and V. aspis venoms cause the expression of the CXCL12‐CXCR4 axis. We also show that a small molecule agonist of CXCR4, dubbed NUCC‐390, induces a rapid regeneration of the motor axon terminal with functional recovery of the neuromuscular junction. These findings qualify NUCC‐390 as a promising novel therapeutics capable of improving the recovery from the paralysis caused by the snakebite of the two neurotoxic Alpine vipers.image
Tolerability and efficacy assessment of an oral collagen supplement for the improvement of biophysical and ultrasonographic parameters of skin in middle eastern consumers
Authors: Samadi Aniseh , Movaffaghi Maryam , Kazemi Faegheh , Yazdanparast Taraneh , Ahmad Nasrollahi Saman , Firooz Alireza 
Published: March 2023

AbstractBackgroundTopical skin care products often do not reach the deeper layers of the skin, and oral hydrolyzed collagen is one of the newest and most popular systemic supplementations for skin rejuvenation. However, there are limited information in case of Middle Eastern consumersObjectiveThe purpose of this study was to evaluate the tolerability and efficacy of an oral collagen supplement for improvement of skin elasticity, hydration, and roughness in Middle Eastern consumers.Methods and MaterialsIt was a 12‐week, before‐after clinical study, conducted on 20 participants (18 women and 2 men) aged 44.15 ± 5.36 years with skin type III–IV. Skin elasticity parameters (R0, R2, R5, and R7), skin hydration and friction, as well as the thickness and echo density of the dermis, were measured after six and 12 weeks daily intake of the study product, as well as 4 weeks after stopping its use (week 16). Participants' satisfaction was assessed on the basis of their answers to the standard questionnaire, and tolerability of the product was assessed by monitoring the adverse effects.ResultsA significant improvement was detected in R2, R5, and skin friction at week 12 (p‐values 0.041, 0.012 and <0.01, respectively). At week 16, the values remained at an increased level, which indicates the persistence of the results. The increase of dermis density in week 16 was also significant (p‐value = 0.03). Moderate overall satisfaction was reported with the treatment, and a few gastrointestinal complications were reported.ConclusionThe study demonstrated that oral collagen peptides could significantly improve the skin elasticity, roughness, and dermis echo density, and they also proved to be safe and well‐tolerated.
Assessment of quality of life and self‐esteem in male patients with androgenetic alopecia before and after hair transplantation
Authors: Nilforoushzadeh Mohammad Ali , Golparvaran Maryam , Yekaninejad Mir Saeed 
Published: March 2023

AbstractBackgroundPatients with androgenetic alopecia experience a significant decrease in self‐esteem and quality of life. There are several methods by which these factors may be improved.AimsDetermining whether patients feel better about themselves with a better quality of life after undergoing hair transplant procedure.Patients/Methods35 people were chosen from Jordan Skin and Hair Clinic in Tehran, Iran. Following hair transplant, follow‐up subjects had their quality of life and level of self‐esteem assessed using the Rosenberg Self‐Esteem Scale (RSES) and Dermatology Life Quality Index (DLQI), respectively. The means of quantitative results were compared using paired T‐test. The chi‐square test was done to compare preoperative and postoperative characteristics qualitatively. Differences were regarded significant if p < 0.05. Analysis of covariance was applied to evaluate the effect of marital status and educational level on outcome variables (ANCOVA).ResultsOur findings showed a statistically significant difference (p < 0.001) between pre‐ and post‐operative hair transplantation for quality of life, and mean score increased to 2.17. There was a statistically significant difference between the two groups, with an average self‐esteem score on RSES rising to 5.35 (p < 0.001). A statistically significant link between educational achievement and quality of life was found (p < 0.001).ConclusionThis study found postoperative psychological aspects of AGA patients significantly improve than preoperative. Our results show that there is a statistically significant difference between the self‐esteem and quality of life of AGA patients before and after hair restoration surgery.
Prevalence of temporomandibular disorders in children and adolescents evaluated with Diagnostic Criteria for Temporomandibular Disorders: A systematic review with meta‐analysis
Authors: Minervini Giuseppe , Franco Rocco , Marrapodi Maria Maddalena , Fiorillo Luca , Cervino Gabriele , Cicciù Marco 
Published: March 2023

AbstractBackgroundThe prevalence of temporomandibular disorders (TMDs) in children and adolescents is not well‐known. This is partly because TMD is not often diagnosed in children and partly because there is no agreed‐upon definition of TMD. There is a growing body of evidence to suggest that there are gender differences in the prevalence and presentation of TMD in adult. The aim was to assess the prevalence of TMDs in subjects aged 8–19 evaluated with Diagnostic Criteria for TMDs (DC/TMD) and to assess gender differences.MethodsPubMed, Web of Science and Lilacs were systematically searched until 30 November 2022, to identify studies presenting children and adolescents patients affected by TMDs.ResultsOut of 40 papers, three studies were included. The included subjects in this review were 1914 (1093 female and 821 male). Seven hundred and thirty‐six on 1914 patients (38.4%) presented TMD. Among 1093 female, 489 (44.7%) presented TMD, while 247/821 male (30%) experienced TMD. Meta‐analysis revealed that the female had a higher TMD prevalence than male (RR 2.10; 95% CI: 1.21–3.65).ConclusionTMD prevalence in children and adolescence varies between 20% and 60%. Female had a higher prevalence of TMDs compared to male.
Prevalence of and prognostic factors for Candida superinfection in oral lichen planus and lichenoid reactions: A retrospective cohort study
Authors: Saepoo Jirayu , Kerdpon Duangporn , Pangsomboon Kanokporn 
Published: March 2023

AbstractBackgroundOral candidiasis occasionally occurs in patients with oral lichen planus (OLP) or lichenoid reaction (OLR). However, not all patients undergoing corticosteroid therapy develop Candida superinfection. Thus, the identification of prognostic risk factors may help to identify patients at risk of Candida superinfection.MethodsA retrospective cohort study was conducted to review patients with OLP/OLR who received steroid therapy at a single dental hospital between January 2016 and December 2021. The prevalence of Candida superinfection and prognostic factors were assessed.ResultsEighty‐two eligible patients with OLP/OLR were retrospectively reviewed. The overall prevalence of Candida superinfection during the study period was 35.37%; the median time‐to‐event between initiation of corticosteroid therapy and diagnosis of superinfection was 60 days (interquartile range; 34–296). The ulcerative type of OLP/OLR, number of topical steroid applications, poor oral hygiene, and oral dryness were significantly associated with superinfection (p < 0.05; Fisher's Exact test) and were identified as prognostic factors in univariable risk ratio regression. Multivariable risk ratio regression revealed the ulcerative type of OLP/OLR and number of topical steroid applications were significant prognostic factors for Candida superinfection in patients with OLP/OLR.ConclusionCandida superinfection occurs in approximately one‐third of patients with OLP/OLR undergoing corticosteroid therapy. Patients with OLP/OLR should be closely monitored in the first 2 months (60 days; median time to infection) after steroid prescription. The ulcerative type of OLP/OLR and a higher number of topical steroid applications per day may represent prognostic factors to identify patients at risk of Candida superinfection.
Optimal estimating function for weak location‐scale dynamic models
Authors: Francq Christian , Zakoïan Jean‐Michel 
Published: March 2023

Estimating functions provide a very general framework for the statistical inference of dynamic models under weak assumptions. We consider a class of time series models consisting in the parametrization of the first two conditional moments which – by contrast with classical location‐scale dynamic models – do not impose further constraints on the conditional distribution/moments. Quasi‐likelihood estimators (QLE) are obtained by solving estimating equations deduced from those two conditional moments. Conditions ensuring the existence and asymptotic properties (consistency and asymptotic normality) of such estimators are provided. We propose optimal QLEs in Godambe's sense, deduced from a condition obtained by Chandra and Taniguchi (2001,Annals of the Institute of Statistical Mathematics53, 125–141). The particular case of the quasi‐maximum likelihood estimators is considered. For pure location models, a data‐driven procedure for optimally choosing the QLE is proposed. Our results are illustrated via Monte Carlo experiments and real financial data.
Community collections: Returning to an (un)imagined future
Authors: Massola Catherine 
Published: March 2023

AbstractDrawing on fieldwork in an Aboriginal community in Western Australia, this article chronicles the life of a collection of Indigenous art and material culture through archival research, ethnography, observation, and interviews. Moving from a school to community keeping spaces, through a natural disaster, to an art center and a university conservation center, this examination reveals how entanglements between people and the collection play out in the local context. The moving and returning of the collection signifies various trajectories that articulate with different value systems and demonstrates that negotiating differences between groups and individuals is an inevitable and necessary part of maintaining and caring for collections in source communities. The article attests that time is needed at local levels to support Indigenous‐led processes which include value creation, cultural protocols, change, continuity, and the (re)valuation of objects.
Comparing the relative influence of obesity and ancestry on timing of dental development
Authors: Strumpf Matthew , Marion Ian , AlQahtani Sakher , da Fonseca Marcio A. , Nicholas Christina L. 
Published: March 2023

AbstractIntroductionThe dentition is one of the most accurate features for age estimation in children. However, there is some evidence that timing of dental development varies across populations. Recent research suggests that dental development may also be susceptible to influence by environmental factors, such as obesity. Given that there are also population differences in average body mass, it is possible that this may be a confounding variable that was not accounted for in prior work. We aim to compare the relative association between body mass index (BMI) and ancestry with timing of dental development.MethodsA retrospective cross‐sectional chart review was undertaken using panoramic radiographs of 6‐ to 12‐year‐olds (n = 281). Age, ancestry, sex, height, and weight were obtained. Dental development was assessed using the Demirjian method, and chronological age was subtracted from estimated dental age to determine relative timing of dental development (ΔAge). BMI was calculated based upon recorded height/weight within 6 months of time of radiograph.ResultsWe found no difference in timing of dental development (accelerated/delayed) across ancestry groups (African‐American, Euro‐American, Hispanic, Asian; P = .15). Overweight/obese subjects had statistically significantly advanced (precocious) dental development (P < .001). Compared to normal‐weight subjects, children who were overweight's age were overestimated by 5.76 months (0.48 years) and children with obesity by 5.97 months (0.49 years) on average.ConclusionsBMI appears to have a greater impact on relative timing of dental development than ancestry in this population. Our results support other findings that obesity results in accelerated growth and development.
Pregabalin in patients with post‐traumatic peripheral neuropathic pain: A meta‐analysis of randomized controlled trials
Authors: Maleki Mohsen Saheban , Zamani Zahra , Amiri Roya , Kakhki Samaneh , Jafari Mojtaba , Amani Behnam , Amani Bahman , Amanat Nasir 
Published: March 2023

AbstractObjectiveThe aim of the study was to investigate the safety and efficacy of pregabalin versus placebo in post‐traumatic peripheral neuropathic pain (PTNP).MethodsPubMed, Cochrane Library, Web of Science, and Google Scholar were searched for relevant evidence up to January 2022. The Cochran tool was used to assess the quality of randomized clinical trials (RCTs). Data analysis was performed using Comprehensive Meta‐Analysis software.ResultsThree RCTs involving 821 patients were included in the meta‐analysis. A significant difference was observed between pregabalin and placebo in terms of the pain score (the standardized mean difference [SMD] = −0.14, 95% CI: 0.28 to −0.006, p = 0.04) and sleep interference (MD = −0.25, 95% CI: −0.39 to −0.11, p = 0.00). There was also a significant difference between pregabalin and placebo regarding somnolence (risk ratio [RR] = 2.78; 95% CI: 1.64–4.71, p = 0.00), dizziness (RR = 4.13; 95% CI: 2.71–6.28, p = 0.00), and disturbance in attention (RR: 2.97; 95% CI: 1.02–8.65, p = 0.04). However, no significant difference was observed between pregabalin and placebo in terms of headache (RR = 1.20; 95% CI: 0.70–2.06, p = 0.50), fatigue (RR = 1.42; 95% CI: 0.82–2.47, p = 0.20), nausea (RR = 1.52; 95% CI: 0.88–2.62, p = 0.13), constipation (RR = 1.84; 95% CI: 0.78–4.29, p = 0.15), and discontinuation (RR = 1.52; 95% CI: 0.45–5.06, p = 0.49).ConclusionCompared with placebo, pregabalin showed better efficacy in reducing PTNP and improving sleep interference. However, it was associated with higher adverse events. Further RCTs are needed to confirm these findings.
Accountability, governance, and institutional change in intergovernmental relations: A theoretical framework
Authors: Benveniste Joseph , Mizrahi Shlomo 
Published: March 2023

AbstractThis article develops an explanatory framework of institutional change in intergovernmental relations. Using new institutionalism, we focus on a main explanatory factor—the players' perceptions of their own accountability and that of others. Integrating the concepts of multiple accountability and felt accountability, we develop the concept of an accountability gap, meaning differences between the perceptions of players in the central government about their responsibility to provide local services and the perceptions of players at the local level about their responsibilities. Our claim is that perceptual gaps concerning accountability in a two‐tiered or multi‐tiered system may influence their interests, strategies, and behavior and hence determine the timing and pace of specific institutional changes. We illustrate the theoretical framework by examining how Spain managed the COVID‐19 pandemic.Related ArticlesAguado, N. Alexander. 2018. “Mayor‐Council Form of Government and Policy Responses in Times of Economic Travail.”Politics & Policy46(5): 714–30.https://doi.org/10.1111/polp.12273.French, Edward P., and Doug Goodman. 2011. “Local Government Human Resource Management Past, Present, and Future: Revisiting Hays and Kearney's Anticipated Changes a Decade Later.”Politics & Policy39(5): 761–85.https://doi.org/10.1111/j.1747‐1346.2011.00312.x.Kwon, Sung‐Wook, and Sylvia Gonzalez‐Gorman. 2019. “Influence of Local Political Institutions on Policy Punctuation in Three Policy Areas.”Politics & Policy47(2): 300–25.https://doi.org/10.1111/polp.12295.
On the multiresource flexible job‐shop scheduling problem with arbitrary precedence graphs
Authors: Kasapidis Gregory A. , Dauzère‐Pérès Stéphane , Paraskevopoulos Dimitris C. , Repoussis Panagiotis P. , Tarantilis Christos D. 
Published: March 2023

This paper aims at linking the work presented in Dauzère‐Pérès et al. (1998) and more recently in Kasapidis et al. (2021) on the multiresource flexible job‐shop scheduling problem with nonlinear routes or equivalently with arbitrary precedence graphs. In particular, we present a mixed integer linear programming (MIP) model and a constraint programming (CP) model to formulate the problem. We also compare the theorems introduced in Dauzère‐Pérès et al. (1998) and Kasapidis et al. (2021) and propose a new theorem extension. Computational experiments were conducted to assess the efficiency and effectiveness of all propositions. Lastly, the proposed MIP and CP models are tested on benchmark problems of the literature and comparisons are made with state‐of‐the‐art algorithms.
Assumptions, uncertainty, and catastrophic/existential risk: National risk assessments need improved methods and stakeholder engagement
Authors: Boyd Matt , Wilson Nick 
Published: March 2023

AbstractTwo key shortcomings of national risk assessments (NRAs) are: (1) lack of justification and transparency around important foundational assumptions of the process, (2) omission of almost all the largest scale risks. Using a demonstration set of risks, we illustrate how NRA process assumptions around time horizon, discount rate, scenario choice, and decision rule impact on risk characterization and therefore any subsequent ranking. We then identify a neglected set of large‐scale risks that are seldom included in NRAs, namely global catastrophic risks and existential threats to humanity. Under a highly conservative approach that considers only simple probability and impact metrics, the use of significant discount rates, and harms only to those currently alive at the time, we find these risks have likely salience far greater than their omission from national risk registers might suggest. We highlight the substantial uncertainty inherent in NRAs and argue that this is reason for more engagement with stakeholders and experts. Widespread engagement with an informed public and experts would legitimize key assumptions, encourage critique of knowledge, and ease shortcomings of NRAs. We advocate for a deliberative public tool that can support informed two‐way communication between stakeholders and governments. We outline the first component of such a tool for communication and exploration of risks and assumptions. The most important factors for an “all hazards” approach to NRA are ensuring license for key assumptions and that all the salient risks are included before proceeding to ranking of risks and considering resource allocation and value.
Climate change and spatial agricultural development in Turkey
Authors: Karahasan Burhan Can , Pinar Mehmet 
Published: March 2023

AbstractThis paper investigates the impact of climate change on the spatial distribution of agricultural production in Turkey between 2004 and 2019. Our findings show that climate change has a pervasive impact on agricultural development. The empirical results show that the average temperature is negatively associated with agricultural land use, grain, and legume production. Moreover, regional variability analyses reveal the nonmonotonic relationships between climatic factors and agricultural output. Climate change hurts agricultural production in northern and central regions the most. This finding points out the ineffectiveness of one‐size‐fits‐all‐type policies for mitigating the adverse effects of climate change in topography with sizeable spatial dissimilarities. Overall, our results suggest that climate change will significantly threaten the evolution of agricultural activities that are critical for regional development. In addition, findings show that spatial spillovers and heterogeneity will be crucial for designing climate change policies for rural and agricultural development.
Dynamics of the rogue lump in the asymmetric Nizhnik–Novikov–Veselov system
Authors: Guo Lijuan , Wang Lihong , Chen Lei , He Jingsong 
Published: March 2023

AbstractThe (2 + 1)‐dimensional asymmetric Nizhnik–Novikov–Veselov (ANNV) equation describes an incompressible fluid such as waves with weakly nonlinear restoring forces, long internal waves in a density‐stratified ocean, or acoustic waves on a crystal lattice. In this paper, we construct a new kind of solutions doubly localized in both time and space, that is, a rogue lump wave, of the ANNV equation using the binary Darboux transformation (BDT). This solution is expressed by a class of semirational functions, in which lumps appear from one line soliton and then rapidly disappear into another line soliton. Phase parameter newly introduced in eigenfunctions plays a vital role in controlling the distinct dynamical behaviors of these rogue lumps. The explicit formulas of the approximate locations and heights of rogue waves, lumps, and line solitons are given by asymptotic analysis. Their collision process is discussed in detail. These results further help us to understand the extreme and transient waves in a variety of physical systems.