bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einstein and Jordan frame correspondence in quantum cosmology: expansion-collapse duality
Authors: Mukherjee Dipayan , Sahota Harkirat Singh 
Published: September 2023

AbstractThe conformal correspondence between FLRW universes in the Einstein and Jordan frames allows for an expansion-collapse duality – an always expanding Einstein frame universe can have a dual Jordan frame description that is contracting forever. The scenario eventually runs into an apparent paradox. When the contracting Jordan frame universe becomes sufficiently small, the classical description becomes inadequate and the universe is expected to develop quantum characteristics. However, at this time, the corresponding Einstein frame universe is expected to behave classically, due to the arbitrarily large size it has grown to. The conformal map here appears to be providing a duality between a quantum effect-dominated universe and a classical universe. We investigate the status of the conformal map at the quantum level in such a scenario, focusing on addressing this paradox. The Einstein and Jordan frame universes are quantized using the Wheeler-DeWitt prescription. We show that the classical conformal map holds at the quantum level when compared through expectation values of scale factors. The relative quantum fluctuation in the scale factor becomes conformally invariant, it increases in both the past and future directions according to the internal clock. Expectedly, the quantum fluctuations in the collapsing Jordan frame increase as it shrinks towards singularity. More surprisingly, the quantum fluctuations in the expanding Einstein frame increase as well, even as its classical scale factor becomes larger. Despite having drastically different cosmological evolutions, the rise in quantum characteristics in a collapsing frame implies the same in its expanding counterpart, thereby resolving the apparent paradox.
The potential to probe solar neutrino physics with LiCl water solution
Authors: Shao Wenhui , Xu Weiran , Liang Ye , Luo Wentai , Xu Tong , Qi Ming , Zhang Jialiang , Xu Benda , Wang Zhe , Chen Shaomin 
Published: September 2023

AbstractA solar neutrino detector relying on the charged-current (CC) interaction of $$\nu _e$$

ν
e

on $$\mathrm{{}^{7}Li}$$

7

Li

is attractive. The total CC interaction cross-section weighted by the solar $$^8$$

8

B electron neutrino spectrum is approximately 60 times that of the neutrino-electron elastic scattering process. The final state effective kinetic energy after the CC interaction on $$\mathrm{{}^{7}Li}$$

7

Li

directly reflects the neutrino energy, which stands in sharp contrast to the plateau structure of recoil electrons of the elastic scattering. The recent measurement of the optical properties of saturated LiCl water solution, especially the long attenuation length, has once again aroused our interest in LiCl. In this work, with new B(GT) experimental measurements, the CC cross-section on $$\mathrm{{}^{7}Li}$$

7

Li

is reevaluated to be $$3.759\times 10^{-42}~\textrm{cm}^2$$

3.759
×

10

-
42

cm
2

. Given the high solubility of LiCl of 74.5 g/100 g water at 10 $$^\circ $$

∘

C and the high natural abundance of 92.41% of $$\mathrm{{}^{7}Li}$$

7

Li

, a solar neutrino detection proposal is made. The detector with high concentration LiCl water solution has a comparable CC event rate of $$\nu _e$$

ν
e

on $$\mathrm{{}^{7}Li}$$

7

Li

with that of neutrino-electron elastic scattering. The contained $$\mathrm{{}^{35}Cl}$$

35

Cl

, $$\mathrm{{}^{6}Li}$$

6

Li

, and H also make a delayed-coincidence detection for $${{\bar{\nu }}}_e$$

ν

¯

e

possible. The advantages of studying the upturn effect of solar neutrino oscillation, light sterile neutrinos, and Earth matter effect are investigated in detail. The sensitivities in discovering solar neutrino upturn and light sterile neutrinos are presented.
Underestimating the uncertainty of aggregated results: the case of W-Boson mass
Authors: Costello Fintan , Watts Paul 
Published: September 2023

AbstractEstimates of uncertainty or variance in experimental means are central to physics. This is especially the case for ‘world averages’ of fundamental parameters in particle physics, which aggregate results from a number of experiments to express current knowledge about these parameters and where variances in these world averages reflect uncertainty in that knowledge. The standard aggregation method used in Particle Data Group reports to estimate such parameters is a form of fixed-effect meta-analysis. One problem with the fixed-effect approach is that it assumes no random variation between experiments (that is, no variation in experimental accuracy, which becomes increasingly important as experimental precision rises). This problem is well-known in the statistical literature, where the typical recommendation is to use random- rather than fixed-effect techniques. We illustrate this problem by applying random-effect meta-analysis to estimates of the W-Boson mass.
Monogamy properties of quantum correlations in neutrino oscillations
Authors: Wang Guang-Jie , Li Yu-Wen , Li Li-Juan , Song Xue-Ke , Wang Dong 
Published: September 2023

AbstractThe monogamy relation of quantum states has limited the shareability properties of quantum resources in multiparty quantum systems. It plays a vital role in information distribution and transformation over many sites in quantum communications. Here, we focus on the monogamy relations of quantum correlations in the context of three-flavor neutrino oscillations, related to the squared entanglement of formation, the squared of quantum discord and its geometric variant. The monogamy relations in terms of the squared entanglement of formation work for the electron and muon antineutrino oscillations, suggesting that the bipartite entanglement measured by squared entanglement of formation of the three-flavor neutrino system set a limitation to the sum of pairwise squared entanglement of formation. Furthermore, we found that the squared quantum discord is also monogamous in three-flavor neutrino system. As a comparison, we test the monogamy of the quantum discord in neutrino oscillations with the result that the quantum discord is not monogamous. In addition, it is found that the bipartite geometric quantum discord of three-flavor systems is equal to the sum of the pairwise geometric quantum discord, i.e., the monogamy relation for geometric quantum discord is saturated for three-flavor neutrino system. These monogamy relations of quantum correlations provide a way for studying the distribution of quantum resources in neutrino oscillations, which is of significance to explore the further applications of neutrino oscillations in quantum communications.
High energy bremsstrahlung at the FCC-ee, FCC-eh and LHeC
Authors: Piotrzkowski Krzysztof , Przybycien Mariusz 
Published: September 2023

AbstractBremsstrahlung spectra will be strongly distorted due to small lateral beam sizes at future colliders. That in turn will have large consequences for the electron and positron beam lifetimes as well as for the luminosity measurements in the case of electron-hadron colliders. We discuss in detail such consequences for the future circular collider and large hadron electron collider cases.
Magnetization in superconducting corrector magnets and impact on luminosity–calibration scans in the Large Hadron Collider
Authors: Chmielińska Agnieszka , Fiscarelli Lucio , Hostettler Michi , Kozanecki Witold , Russenschuck Stephan , Todesco Ezio 
Published: September 2023

AbstractSuperconducting accelerator magnets have a nonlinear dependence of field on current due to the magnetization associated with the iron or with persistent currents in the superconducting filaments. This also gives rise to hysteresis phenomena that create a dependence of the field on the powering history. Magnetization effects are of particular importance for luminosity–calibration scans in the Large Hadron Collider, during which a small number of Nb–Ti superconducting orbit correctors are excited at low field and with frequent flipping of the sign of the current ramp. This paper focuses on the analysis of special measurements carried out to estimate these nonlinear effects under the special cycling conditions used in these luminosity scans. For standard powering cycles, we evaluate the effect of the main magnetization loop; for complex operational schemes, magnetization-branch transitions occur that depend on the details of the current cycle. The modelling of these effects is not included in the magnetic field prediction software currently implemented in the LHC control system; here we present an approach to predict the transitions between the main magnetization branches. The final aim is to estimate the impact of magnetic hysteresis on the accuracy of luminosity-calibration scans.
Abstract PO-084: Deletion of macrophage migration inhibitory factor promotes antitumoral T cell infiltration and inhibits MDSC recruitment to the head and neck cancer microenvironment
Authors: Oghumu Steve 
Published: September 2023

Abstract
Head and neck squamous cell carcinoma (HNSCC) is a significant public health concern worldwide. Immunomodulatory targets in the HNSCC tumor microenvironment are crucial to enhance the efficacy of HNSCC immunotherapy. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that has been linked to worse prognosis in many cancers, but the mechanistic role of MIF in HNSCC remains unclear. Using a murine orthotopic oral cancer model in Mif+/+ or Mif− / − mice, we determined the function of host derived MIF in HNSCC tumor development, metastasis as well as localized and systemic tumor immune responses. We found that Mif− / − mice have decreased tumor growth and burden compared to their wild-type counterparts. Flow cytometric analysis of immune populations within the primary tumor site revealed increased T cell recruitment to the HNSCC tumor microenvironment, within the tumors of Mif− / − mice. MIF deletion also enhanced the effector function of anti-tumoral Th1 cells and decreased the accumulation of granulocytic MDSC in the tumor microenvironment. Furthermore, we show that isolated MDSC chemotactically respond to MIF in a dose dependent manner which is inhibited when MIF is depleted. Interestingly, MDSCs of tumor bearing Mif− / − mice expressed increased levels of PDL1 compared to Mif+/+ mice. However, Mif− / − and Mif+/+ MDSCs have comparable abilities to suppress T cell proliferation. Herein we describe a chemotactic and immunomodulatory role for MIF in the context of HNSCC. MIF targeted immunomodulation remains a potentially viable cancer therapeutic, however more remains to be understood about the cellular interaction of MIF within the tumor microenvironment before these targeted therapies can be effectively employed
Citation Format: Steve Oghumu. Deletion of macrophage migration inhibitory factor promotes antitumoral T cell infiltration and inhibits MDSC recruitment to the head and neck cancer microenvironment [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research; 2023 Jul 7-8; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2023;29(18_Suppl):Abstract nr PO-084.
Rabbis as Nomikoi? Questioning a New Paradigm: A Response to Yair Furstenberg
Authors: Rosen-Zvi Ishay 
Published: September 2023

Abstract
In recent years, a new generation of Talmud scholars rediscovered Roman law as a valuable comparative tool. In addition to localized comparisons, several broad syntheses have been offered by scholars regarding Roman law and rabbinic halakhic thinking. In his article in this issue, “The Rabbinic Movement from Pharisees to Provincial Jurists” (doi: 10.1163/15700631-bja10070), Yair Furstenberg offers to explain the rise of the field of civil law in later Tannaitic literature as part of the rise of the local jurist in the eastern provinces. I seize the opportunity of Furstenberg’s novel thesis to rethink recent trends of comparing Tannaitic halakhah and Roman law and their limitations.
Learning-skill stories completion: A study on the development of 3–6-year-old children's narratives
Authors: Li Rong 
Published: September 2023

The development of children's narrative language is an essential part of their language development, which has a unique value to children's future learning and growth. Many research studies focus on children's narrative ability, but few focus on the completion of Chinese children's stories. In this study, 191 Chinese children aged 3–6 years old in the Shanghai area were selected to collect a story corpus by using the international and general completion pictures of learning stories, supplemented with the method of corpus study to explore the characteristics of children's narrative language development in the learning-skill stories. The study found that the development of vocabulary, syntax, and other aspects of 3–6-year-old children showed an apparent upward trend. The variety of words, the types, and the frequency of nouns and adjectives increased with age. Regarding the perspective of syntactic analysis, the critical stage in the development of syntactic length was about 5 years old. The narrative situation of the learning-skill stories could help children to show a better narrative level. At the age of 3–6, the story structure of children's learning-skill stories gradually became complete and three-dimensional with age, and the richness of children's life experiences was an essential factor in promoting the integrity of the story structure. In the Chinese context, reactive sequences and abbreviated episodes were the main types of story structure in children's narration. The narratives of children's learning-skill stories were influenced by Chinese culture.
Mode and site of action of therapies targeting CGRP signaling
Authors: Labastida-Ramírez Alejandro , Caronna Edoardo , Gollion Cédric , Stanyer Emily , Dapkute Austeja , Braniste Diana , Naghshineh Hoda , Meksa Liga , Chkhitunidze Nino , Gudadze Tamari , Pozo-Rosich Patricia , Burstein Rami , Hoffmann Jan 
Published: September 2023

AbstractTargeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed.
HIV-1-related factors interact with p53 to influence cellular processes
Authors: Liu Shanling , Guo Ting , Hu Jinwei , Huang Weiliang , She Pengfei , Wu Yong 
Published: September 2023

AbstractHuman immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also control viral pathogenesis. For example, HIV-1 regulates the life cycle of p53, which in turn contributes significantly to HIV-1 pathogenesis. In this article, we review the interaction between HIV-1-associated factors and p53, providing information on their regulatory and molecular mechanisms, hinting possible directions for further research.
Obstructive jaundice as a rare complication of multiple pancreaticoduodenal artery aneurysms due to median arcuate ligament syndrome: a case report and review of the literature
Authors: Jalili Javad , Javadrashid Reza , Alvandfar Dara , Falahatian Masih , Jafarizadeh Ali , Alihosseini Samin , Hashemizadeh Seyedeh Elnaz 
Published: September 2023

AbstractBackgroundObstructive jaundice has various causes, and one of the rarest is pancreaticoduodenal artery aneurysm (PDAA), which is often associated with celiac axis stenosis caused by median arcuate ligament syndrome (MALS).Case presentationThe patient was a 77-year-old Azeri woman who presented with progressive jaundice, vague abdominal pain, and abdominal distension from 6 months ago. The intra- and extrahepatic bile ducts were dilated, the liver's margin was slightly irregular, and the echogenicity of the liver was mildly heterogeneous in the initial ultrasound exam. A huge cystic mass with peripheral calcification and compressive effect on the common bile duct (CBD) was also seen near the pancreatic head, which was connected to the superior mesenteric artery (SMA) and had internal turbulent blood flow on color Doppler ultrasound. According to the computed tomography angiography (CTA) findings, the huge mass of the pancreatic head was diagnosed as a true aneurysm of the pancreaticoduodenal artery caused by MALS. Two similar smaller aneurysms were also present at the huge aneurysm's superior margin. Due to impending rupture signs in the huge aneurysm, the severe compression effect of this aneurysm on CBD, and the patient's family will surgery was chosen for the patient to resect the aneurysms, but unfortunately, the patient died on the first day after the operation due to hemorrhagic shock.ConclusionIn unexpected obstructive jaundice due to a mass with vascular origin in the head of the pancreas, PDAA should be considered, and celiac trunk should be evaluated because the main reason for PDAA is celiac trunk stenosis or occlusion by atherosclerosis or MALS. The treatment method chosen (including transarterial embolization, open surgery, or combined method) depends on the patient's clinical status and radiological findings, but transarterial embolization would be safer and should be used as a first-line method.
The SIRT7-mediated deacetylation of CHD1L amplifies HIF-2α-dependent signal that drives renal cell carcinoma progression and sunitinib resistance
Authors: He Hongchao , Li Jie , Wang Wei , Cheng Jie , Zhou Jian , Li Qunyi , Jin Juan , Chen Li 
Published: September 2023

Abstract
Background
Aberrant interplay between epigenetic reprogramming and hypoxia signaling contributes to renal cell carcinoma progression and drug resistance, which is an essential hallmark. How the chromatin remodelers enhance RCC malignancy remains to be poorly understood. We aimed to elucidate the roles of CHD1L in determining hypoxia signaling activation and sunitinib resistance.

Methods
The qRT-PCR, western blotting, and immunohistochemistry technologies were used to detect CHD1L expressions. Lentivirus transfection was used to generate stable CHD1L-KD cells. The roles of SIRT7/CHD1L were evaluated by CCK-8, wound healing, transwell assays, xenograft models, and tail-vein metastasis models. Co-immunoprecipitation, Chromatin Immunoprecipitation (ChIP), and luciferase reporter assays were conducted to explore epigenetic regulations.

Results
We screened and validated that CHD1L is up-regulated in RCC and correlates with poorer prognosis of patients. CHD1L overexpression notably enhances cell proliferation, migration, and self-renewal capacities in vitro and in vivo. Mechanistically, SIRT7 physically interacts with CHDL1 and mediates the deacetylation of CHD1L. Wild-type SIRT7, but not H187Y dead mutant, stabilizes CHD1L protein levels via attenuating its ubiquitination levels. SIRT7 is increased in RCC and correlates with hazardous RCC clinical characteristics. SIRT7 depends on CHD1L to exert its tumor-promoting functions. Accumulated CHD1L amplifies HIF-2α-driven transcriptional programs via interacting with HIF-2α. CHD1L recruits BRD4 and increases the RNA polymerase II S2P loading. CHD1L ablation notably abolishes HIF-2α binding and subsequent transcriptional activation. CHD1L overexpression mediates the sunitinib resistance via sustaining VEGFA and targeting CHD1L reverses this effect. Specific CHD1L inhibitor (CHD1Li) shows a synergistic effect with sunitinib and strengthens its pharmaceutical effect.

Conclusions
These results uncover a CHD1L-mediated epigenetic mechanism of HIF-2α activation and downstream sunitinib resistance. The SIRT7–CHD1L–HIF-2α axis is highlighted to predict RCC prognosis and endows potential targets.
Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen
Authors: Xue Yanfeng , Gong Yingyun , Li Xin , Peng Fei , Ding Guolian , Zhang Zhao , Shi Junchao , Savul Ilma Saleh , Xu Yong , Chen Qi , Han Leng , Mao Shengyong , Sun Zheng 
Published: September 2023

Abstract
Background
Gene-environment interactions contribute to metabolic disorders such as diabetes and dyslipidemia. In addition to affecting metabolic homeostasis directly, drugs and environmental chemicals can cause persistent alterations in metabolic portfolios across generations in a sex-specific manner. Here, we use inorganic arsenic (iAs) as a prototype drug and chemical to dissect such sex differences.

Methods
After weaning, C57BL/6 WT male mice were treated with 250 ppb iAs in drinking water (iAsF0) or normal water (conF0) for 6 weeks and then bred with 15-week-old, non-exposed females for 3 days in cages with only normal water (without iAs), to generate iAsF1 or conF1 mice, respectively. F0 females and all F1 mice drank normal water without iAs all the time.

Results
We find that exposure of male mice to 250 ppb iAs leads to glucose intolerance and insulin resistance in F1 female offspring (iAsF1-F), with almost no change in blood lipid profiles. In contrast, F1 males (iAsF1-M) show lower liver and blood triglyceride levels than non-exposed control, with improved glucose tolerance and insulin sensitivity. The liver of F1 offspring shows sex-specific transcriptomic changes, with hepatocyte-autonomous alternations of metabolic fluxes in line with the sex-specific phenotypes. The iAsF1-F mice show altered levels of circulating estrogen and follicle-stimulating hormone. Ovariectomy or liver-specific knockout of estrogen receptor α/β made F1 females resemble F1 males in their metabolic responses to paternal iAs exposure.

Conclusions
These results demonstrate that disrupted reproductive hormone secretion in alliance with hepatic estrogen signaling accounts for the sex-specific intergenerational effects of paternal iAs exposure, which shed light on the sex disparities in long-term gene-environment interactions.
Quantitative evaluation of plants on top surface of the Great Wall in Dazhuangke using the analytical hierarchy process
Authors: Pan Jianbin , Xu Nuo , Tang Yuyang , Cheng Meijing , Zhang Lin , Wang Bing , Lan Jingwen 
Published: September 2023

Abstract
The Great Wall of China was a military facility that has been continuously built and used for over thousands of years, and is a world-renowned cultural heritage site today. The plants growing on top surface of the Great Wall caused the damage of the Great Wall, but the process of removing these plants may further damage the body of the Great Wall. In this paper, based on the Analytic Hierarchy Process and the expert Delphi method, we selected 13 specific indices from three Constraint Layer factors, and then estimated and identified 45 species/categories of plants on top surface of the Dazhuangke section of the Great Wall. The results showthe constitution and the evaluation gradeof the evaluation system. The factor of Disruptive Effects plays the main guidance role in the evaluation system of the Constraint Layer; The indices of Impact on the Near Side Wall is the core element of the evaluation model with the highest weight of the Standard Layer. And the “Preservation”, “Partial Preservation”and “Removal” recommendations were given based on three evaluation grade (from Grade I to Grade III). This research provides scientific basis for the protective repair of the Great Wallheritage as well as "Garden on the Great Wall".