bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quick retreatment with plastic core obturators in curved canals: an in vitro study.
Authors: Gancedo-Gancedo Tania , Martín-Biedma Benjamín , Pereira-Lores Patricia , Martín-González Jenifer , Bello-Castro Alba , Tomás-Carmona Inmaculada , Castelo-Baz Pablo 
Published: September 2023

Abstract
Objectives
Non-surgical retreatment of plastic carrier obturators is complex and requires a superior working time. The aim of this study is to present a new retreatment technique and compare it in terms of safety and speed with a conventional method, in curved canals.
Methods
36 lower premolars were selected and sealed with plastic core obturators. Then, the samples were randomized into two retreatment groups. In both groups, nickel-titanium rotary instruments (Endogal, Sarria, Lugo, Spain) were used to remove the old filling material. In Group 0 (Direct technique) gutta-percha and plastic core were eliminated simultaneously. In Group 1 (Indirect technique), the plastic core was initially extracted with the aid of an ultrasonic tip and a Hedstroem file, and then, the surrounding gutta-percha was removed with rotary instruments.
Results
Time needed for retreatment procedures, plastic carrier fracture, ledge formation and apical transportation were significantly lower in Group 1 (P < 0.05), while there was no statistically significant difference between both groups in terms of remaining material and instrument fracture (P > 0.05). No perforations occurred.
Conclusions
The new indirect technique proved to be safer, since prior withdrawal of the plastic carrier reduces the stress exerted on the rotary instruments and facilitates its advance along the canal, and it also resulted in shorter working time than other previously described methods.
Clinical relevance:
The increased safety of the technique and the reduction in the retreatment time allows to increase the disinfection duration in cases where a complete removal of the old filling material is not achieved.
Distinct Rupture Processes on a Fault where M6-class Earthquakes Reoccurred in a Short Period: Analysis of the 2011 and 2016 Northern Ibaraki, Japan, Earthquakes using Near-field Waveforms
Authors: Hikima Kazuhito 
Published: September 2023

Abstract
Crustal earthquakes are generally recognized as having recurrence periods of more than 1000 years. However, in northern Ibaraki Prefecture, Japan, two moderate-sized earthquakes occurred on almost the same fault plane in 2011 and 2016. Moreover, it has been reported that the slip distributions derived from crustal deformation data from these two events are almost identical. We performed near-field waveform inversion analysis to estimate the details of the spatiotemporal distribution of the co-seismic rupture. Our results reveal large slip areas during each earthquake at different locations across the bend of the fault plane. These results indicate that the shear stress of the fault area where the main slip occurred during the 2011 event was not rebuilt in such a short period, a phenomenon that had not previously been discussed for this sequence. Our results also suggest that the fault geometry affected such complex fault ruptures.
Effect of Water-Rock Interaction on the Compressive Mechanical Properties and Mesoscopic Structure of Granite
Authors: Huang Yaoying , Zhai Yue , Wang Ming , Li Yubai , Li Yan 
Published: September 2023

Abstract
Understanding the impact of water-rock interaction on the mechanical characteristics of rock is of great practical significance in rock engineering. To investigate water-rock interaction on the compressive mechanical properties and mesostructure of granite, specimens were immersed in pure water at 25℃ for 0, 2, 4, and 6 months, then subjected to impact compression tests at different strain rates to analyze the effect of water-rock interaction on mechanical characteristics. Furthermore, mesoscopic experiments such as optical microscope, atomic force microscope, nuclear magnetic resonance and water quality detection were used to explore the meso-structural changes caused by water-rock interaction and reveal the mechanism of water-rock interaction. Finally, a pore size-based and weighted damage evolution model and a water-induced strength softening factor were introduced to describe the damage evolution characteristics and mechanical property degradation mechanism of granite under water-rock interaction. The results show that the uniaxial compressive strength of granite is linearly negatively correlated with the duration of water immersion, and logarithmically positively correlated with the strain rate; the longer the immersion duration, the more sensitive the granite is to the strain rate. During the water-rock interaction, chemical and physical reactions occur between water and granite, which jointly promote pore development. However, the time scale of the two is not consistent. The chemical effect slows down with time, and the physical effect is the opposite.
Mechanism Underlying a Brief Cognitive Behavioral Treatment for Head and Neck Cancer Survivors with Body Image Distress
Authors: Graboyes Evan M. , Kistner-Griffin Emily , Hill Elizabeth G. , Maurer Stacey , Balliet Wendy , Williams Amy M. , Padgett Lynne , Yan Flora , Rush Angie , Johnson Brad , McLeod Taylor , Dahne Jennifer , Ruggiero Kenneth J. , Sterba Katherine R. 
Published: September 2023

Abstract
Purpose: Body image distress (BID) among head and neck cancer (HNC) survivors is a debilitating toxicity associated with depression, anxiety, stigma, and poor quality of life. BRIGHT (Building a Renewed ImaGe after Head & neck cancer Treatment) is a brief cognitive behavioral therapy (CBT) that reduces BID for these patients. This study examines the mechanism underlying BRIGHT.
Methods: In this randomized clinical trial, HNC survivors with clinically significant BID were randomized to receive 5 weekly psychologist-led video tele-CBT sessions (BRIGHT) or dose-and delivery matched survivorship education (attention control [AC]). Body image coping strategies, the hypothesized mediators, were assessed using the Body Image Coping Skills Inventory (BICSI). HNC-related BID was measured with the IMAGE-HN. Causal mediation analyses were used to estimate the mediated effects of changes in BICSI scores on changes in IMAGE-HN scores.
Results: Among 44 HNC survivors with BID, mediation analyses showed that BRIGHT decreased avoidant body image coping (mean change in BICSI-Avoidance scale score) from baseline to 1-month post-intervention relative to AC (p = 0.039). Decreases in BICSI-Avoidance scores from baseline to 1-month decreased IMAGE-HN scores from baseline to 3-months (p = 0.009). The effect of BRIGHT on IMAGE-HN scores at 3-months was partially mediated by a decrease in BICSI-Avoidance scores (p = 0.039).
Conclusions: This randomized trial provides preliminary evidence that BRIGHT reduces BID among HNC survivors by decreasing avoidant body image coping. Further research is necessary to confirm these results and enhance the development of interventions targeting relevant pathways to reduce BID among HNC survivors.
Trial Registration: This trial was registered on ClinicalTrials.gov identifier NCT03831100 on February 5, 2019.
Chiral domain dynamics and transient interferences of mirrored superlattices in nonequilibrium electronic crystals
Authors: Mihailovic Dragan , Ravnik Jan , Vodeb Jaka , Vaskivskyi Yevhenii , Diego Michele , Venturini Rok , Gerasimenko Yaroslav , Kabanov Viktor , Kranjec Andrej 
Published: September 2023

Abstract
Mirror symmetry plays a major role in determining the properties of matter and is of particular interest in condensed many-body systems undergoing symmetry breaking transitions under non-equilibrium conditions. Typically, in the aftermath of such transitions, one of the two possible broken symmetry states is emergent. However, synthetic systems and those formed under non-equilibrium conditions may exhibit metastable states comprising of both left (L) and right (R) handed symmetry. Here we explore the formation of chiral charge-density wave (CDW) domains after a laser quench in 1T-TaS2 with scanning tunneling microscopy. Typically, we observed transient domains of both chiralities, separated spatially from each other by domain walls with different structure. In addition, we observe transient density of states modulations consistent with interference of L and R-handed charge density waves within the surface monolayer. Theoretical modeling of the intertwined domain structures using a classical charged lattice gas model reproduces the experimental domain wall structures. The superposition (S) state cannot be understood classically within the correlated electron model but is found to be consistent with interferences of L and R -handed charge-density waves within domains, confined by surrounding domain walls, vividly revealing for the first time an interference of Fermi electrons with opposite chirality in charge density wave systems.
Long-term humoral and cellular immunity after primary SARS-CoV-2 infection: A 20- month longitudinal study
Authors: Hvidt Astrid Korning , Guo Huaijian , Andersen Rebecca , Lende Stine Sofie Frank , Vibholm Line Khalidan , Søgaard Ole Schmeltz , Schleimann Marianne Hoegsbjerg , Russell Victoria , Cheung Angela Man-Wei , Paramithiotis Eustache , Olesen Rikke , Tolstrup Martin 
Published: September 2023

Abstract
Background
SARS-CoV-2 remains a world-wide health issue. SARS-CoV-2-specific immunity is induced upon both infection and vaccination. However, defining the long-term immune trajectory, especially after infection, is limited. In this study, we aimed to further the understanding of long-term SARS-CoV-2-specific immune response after infection.
Results
We conducted a longitudinal cohort study among 93 SARS-CoV-2 recovered individuals. Immune responses were continuously monitored for up to 20 months after infection. The humoral responses were quantified by Spike- and Nucleocapsid-specific IgG levels. T cell responses to Spike- and non-Spike epitopes were examined using both intercellular cytokine staining (ICS) assay and Activation-Induced marker (AIM) assay with quantification of antigen-specific IFNγ production. During the 20 months follow-up period, Nucleocapsid-specific antibody levels and non-Spike-specific CD4 + and CD8 + T cell frequencies decreased. However, a majority of participants maintained a durable immune responses 20 months after infection: 59% of the participants were seropositive for Nucleocapsid-specific IgG, and more than 70% had persisting non-Spike-specific T cells. The Spike-specific response initially decreased but as participants were vaccinated against COVID-19, Spike-specific IgG levels and T cell frequencies were boosted reaching similar or higher levels compared to 1 month post-infection. The trajectory of infection-induced SARS-CoV-2-specific immunity decreases, but for the majority of participants it persists beyond 20 months. The T cell response displays a greater durability. Vaccination boosts Spike-specific immune responses to similar or higher levels as seen after primary infection.
Conclusions
For most participants, the response persists 20 months after infection, and the cellular response appears to be more long-lived compared to the circulating antibody levels. Vaccination boosts the S-specific response but does not affect the non-S-specific response. Together, these findings support the understanding of immune contraction, and with studies showing the immune levels required for protection, adds to the knowledge of durability of protection against future SARS-CoV-2
Interpretation of Associative Cultural Landscape Based on Text Mining of Poetry –Taking Tianmu Mountain on the Road of Tang Poetry in Eastern Zhejiang as an Example
Authors: Qiao Jinghui , Xi Xuesong , Zhang Guangming , Liang Shifan 
Published: September 2023

Abstract
Revealing the correlation between natural elements and religion, art, or culture through text mining of poetry provides a new perspective for in-depth interpretation of Associative Cultural Landscape. Taking Tianmu Mountain, an important spot on the Road of Tang Poetry in Eastern Zhejiang, as an example, this study focuses on 444 poems written by 269 poets from the Eastern Han Dynasty to the Qing Dynasty in the Tianmu Mountain region. Text mining techniques such as text segmentation and social network analysis were employed to quantitatively analyze and explore the correlation of Landscape terms in the poetry. The findings are as follows: (1) The descriptions in the poems bear witness to the beautiful and diverse Natural Landscape, the abundant Humanistic Landscape, and the unique Folk Landscape of Tianmu Mountain. (2) The poems exhibit a layered structure in which the Natural Landscape serve as the core, and the Humanistic Landscape and the Folk Landscape are interconnected and interact with each other, reflecting the religious characteristic of dual cultivation of Buddhism and Taoism in the context of landscapes in the Tianmu Mountain, the cultural characteristics of rich and flowing traditions, and the artistic characteristics of blending scenes and emotions. This study confirms the close correlation between the natural elements of Tianmu Mountain and religion, art, and culture, providing methodological support for the interpretation of features and values of global Associative Cultural Landscape, as well as important scientific evidence for their overall protection and sustainable utilization.
MgO and ZnO Nanofluids Passive Cooling Effects on the Electricity Production of Photovoltaic Panels: A comparative Study
Authors: Abdulhamid Muhammad Ibrahim , Enein Saad Aboul , Ibrahim Ali 
Published: September 2023

Abstract
Solar panel overheating is a major contributor to conversion efficiency reduction. Hence, cooling down the solar panels is a key strategy for enhancing their electrical output of it as a matter of controlling their thermal properties. This study is set out to examine, experimentally, the back passive cooling effect of MgO and ZnO water-based nanofluids at volume concentrations of 0.01%, 0.03%, and 0.05% on the thermal and electrical characteristics of polycrystalline silicon solar panels, compared with not cooled and with water-cooled panels. The system design is costly-effective and mainly facilitates the direct contact of the fluids to the back of the PV system. From the experimental results, the MgO nanofluid introduced better improvement contrasted to the ZnO nanofluid and the water cooling. The electrical efficiency enhancement reached its maximum at a volume concentration of 0.05% with 20.903% and 21.649% for MgO and ZnO nanofluids, respectively over the non-cooled panel. At this volume concentration, the temperature reduction of MgO nanofluid introduced 20.717%, while it is 15.804% for the ZnO nanofluid above the reference panel.
Factors associated with cam deformity in Japanese local residents
Authors: Tomomatsu Koichi , Taniguchi Takaya , Hashizume Hiroshi , Harada Teiji , Iidaka Toshiko , Asai Yoshiki , Oka Hiroyuki , Muraki Shigeyuki , Akune Toru , Kawaguchi Hiroshi , Nakamura Kozo , Yoshida Munehito , Tanaka Sakae , Yoshimura Noriko , Yamada Hiroshi 
Published: September 2023

Abstract
Femoroacetabular impingement has increasingly been recognized as a cause of primary hip osteoarthritis; however, its epidemiological indications remain unclear. We aimed to clarify the epidemiological indications and factors associated with cam deformity in a large-scale population-based cohort in Japan. Overall, 1,480 participants (491 men, 989 women; mean age, 65.3 years) analyzed in the third survey of the Research on Osteoarthritis/Osteoporosis Against Disability study were included. The α angle and spinopelvic parameters (lumbar lordosis [LL], sacral slope [SS], pelvic tilt, and pelvic incidence) were radiographically measured. Cam deformity was defined as an angle ≥ 60°. Overall, 7.3% of patients had cam deformity on at least one side. Cam deformity prevalence tended to increase with age; a higher percentage of men was observed in the group with cam deformity than in that without it in the univariate analysis. LL and SS were significantly lower in the group with cam deformities. No relationship was observed between cam deformity and hip pain. Factors associated with α angle were examined via multiple regression analysis; α angle was significantly associated with age and male sex. Thus, α angle and cam deformity prevalence increase with age in Japanese individuals. Accordingly, cam deformity can be a developmental disease.
Skin Mast Cells in Marfan Syndrome: Specific Emphasis on Connective Tissue Remodeling
Authors: Atiakshin Dmitri , Nikolaeva Ekaterina , Gritsevskaya Daria , Semyachkina Alla , Kostin Andrey , Volodkin Artem , Morozov Sergey , Dlin Vladimir , Ignatyuk Michael , Mikhaleva Liudmila , Elieh-Ali-Komi Daniel , Tiemann Markus , Buchwalow Igor 
Published: September 2023

Abstract

Marfan syndrome (MFS) is a hereditary condition accompanied by disorders in the structural and regulatory properties of the connective tissue, including elastic fibers, due to a mutation in the FBN1 gene and the synthesis of abnormal fibrillin 1 glycoprotein. Despite the high potential of mast cells (MCs) to remodel the extracellular matrix (ECM), their pathogenetic significance in MFS has not been considered yet. An analysis of the skin MC population in children with Marfan syndrome revealed a considerably increased number of intraorganic populations with preservation of the specific protease Tryptase+Chymase+CPA3+ profile typical of the skin. The features of the MC histotopography phenotype in MFS consisted of closer colocalization with elastic fibers, smooth muscle cells and fibroblasts. MCs formed many intradermal clusters that synchronized the activity of cell functions in the stromal landscape of the tissue microenvironment with the help of spatial architectonics, including the formation of cell chains and the creation of fibrous niches. In MCs, the expression of specific proteases, TGF-β and heparin increased with targeted secretion of biologically active substances to the dermal elastic fibers, which, in MFS, had specific structural features, including abnormal variability in thickness along the entire length, alternation of thickened and thinned areas, and uneven surface topography. The paper discusses the potential role of MCs in strain analysis (tensometry) of the tissue microenvironment in MFS. Thus, quantitative and qualitative rearrangements of the skin MC population in MFS are aimed at altering the stromal landscape of the connective tissue. The results obtained should be taken into account when managing clinical signs of MFS manifested in other pathogenetically critical structures of internal organs, including the aorta, tendons, cartilage and parenchymal organs.
Prediction of Bleeding in Placenta Accrete Spectrum with Lacunar Surface; A Novel Aspect
Authors: Vahdani Fahimeh Gotbizadeh , Shabani Azadeh , Haddadi Mohammad , Ghalandarpoor-Attar Seyedeh Mojgam , Panahi Zahra , Hantoushzadeh Sedigheh , Borna Sedigheh , Deldar Maryam , Ghashghaee Sanaz , Shariat Mamak 
Published: September 2023

Abstract

Background:
Diagnosing the placenta accreta spectrum for suspicious pregnant women is crucial to prevent morbidities and mortalities among them. We aim to evaluate the novel ultrasonography markers for these patients in diagnosis and predicting prognosis.
Method and Materials:
This cross-sectional study was performed in a referral academic hospital. The population was 51 pregnant women suspicious of PAS. Their primary information and medical and surgical histories were documented. Then the ultrasonography markers, including the most bulging volume behind the bladder(area, perimeter, and volume), the Lacune(diameter, length, number, and surface of the largest lacuna obtained by multiplying the length by the width), the most considerable thickness of placenta on the cervix in patients with placenta previa, the most considerable thickness of the placenta behind the bladder, the Jellyfish sign, and sponge cervix were evaluated. Their comparison to the severity of the bleeding, the rate of the hysterectomy, and the following pathology of the PAS were analyzed.
Result:
17(33.3%) of patients had severe bleeding. The diameter, length, and surface of the largest lacunae limited to women with severe bleeding were 13.50(5.5-21), 20.50(11-56), 273.00(60-1176), and they were 11.00(5-24), 16.25(10-39), and 176.25 (50-744) for women without severe bleeding (P-value= 0.039, 0.027, 0.021). 13(76.5%) women with severe bleeding had Jellyfish signs,16(94.2%) had bulging on the cervix, and 10(58.8%) had sponge cervix (P-value=0.046, 0.036, 0.006). 34 (66.66%) patients needed hysterectomy. The diameter, length, and surface of the largest lacunae limited to women with hysterectomy were 11.00(5-24), 17.50(10-39), 181.50 (50-744), and they were 15.00(12-18), 20.50(14-27), and 327.00(168-1176) for women without hysterectomy (P-value= 0.012, 0.070, 0.021). 24(70.6%) women with hysterectomy had Jellyfish signs, 29(85.3%) of them had bulging on the cervix, and 15(44.1%) had sponge cervix (P-value=0.05, 0.036,0.028 ). the cut-off associated with the Lacunar surface was 163.5 Its sensitivity was 80%. Its specificity was 48% (p-value=0.021).
Conclusion:
The presence of single large lacunae could be a suitable predictive factor for bleeding in the placenta accreta spectrum; also, there are some other US criteria, including the presence of sponge cervix and Jellyfish sign as predictive factors for consequences in this spectrum, including hysterectomy.
Celastrol Ameliorates Lupus by Promoting Apoptosis of Autoimmune T Cells and Preventing Autoimmune Response in MRL/lpr Mice
Authors: Xie Tianhong , Liu Huiqiang , Liu Xin , Liu Xiang , Li Ping 
Published: September 2023

Abstract

Celastrol is a bioactive constituent extracted from tripterygium wilfordii (Thunder God Vine). In the present study, we investigated whether Celastrol could have a regulatory effect on the autoimmune response in MRL/lpr mice. Our results demonstrated that Celastrol had a therapeutic effect on MRL/lpr mice by preventing the enlargement of the spleen and lymph nodes, alleviating renal injury, and reducing the levels of ANA and anti-dsDNA antibodies. Furthermore, Celastrol suppressed the in vivo inflammatory response in MRL/lpr mice by dramatically reducing the serum levels of multiple cytokines and production of antibody subsets. In addition, Celastrol treatment reduced in vitro anti-CD3 antibody stimulation-induced the number of Th1 and TNF-producing cells in CD4 + T cells of MRL/lpr mice. Celastrol treatment significantly affected B cell differentiation and prevented the generation of plasma cells from B cells in MRL/lpr mice by decreasing the number of activated and germinal center B cells. This contributed to the reduced secretion of autoantibodies in Celastrol-treated MRL/lpr mice. Celastrol treatment also affected T-cell differentiation and significantly reduced Tcm cell frequencies in MRL/lpr mice. Importantly, Celastrol treatment markedly and specifically promoted apoptosis of CD138 + T cells and suppressed autoimmune T-cell accumulation in MRL/lpr mice. The reduced number of CD138 + T cells further affected B-cell differentiation and subsequently resulted in the reduced number of autoreactive plasma cells which led to the reduced secretion of autoantibodies. Our results indicated that Celastrol had therapeutic effects on lupus by specifically promoting apoptosis of autoimmune T cells.