bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passive Quantum Measurement: Arrival Time, Quantum Zeno Effect and Gambler's Fallacy
Authors: Jurić Tajron , Nikolić Hrvoje 
Published: July 2023

AbstractClassical measurements are passive, in the sense that they do not affect the physical properties of the measured system. Normally, quantum measurements are not passive in that sense. In the infinite dimensional Hilbert space, however, it is found that quantum projective measurement can be passive in a way which is impossible in finite dimensional Hilbert spaces. Specifically, it is found that expectation value of a hermitian Hamiltonian can have an imaginary part in the infinite dimensional Hilbert space and that such an imaginary part implies a possibility to avoid quantum Zeno effect, which can physically be realized in quantum arrival experiments. The avoidance of quantum Zeno effect can also be understood as avoidance of a quantum version of gambler's fallacy, leading to the notion of passive quantum measurement that updates information about the physical system without affecting its physical properties. The arrival time probability distribution of a particle is found to be given by the flux of the probability current. Possible negative fluxes correspond to regimes at which there is no arrival at all, physically understood as regimes at which the particle departs rather than arrives.
CSR decoupling within business groups and the risk of perceived greenwashing
Authors: Bothello Joel , Ioannou Ioannis , Porumb Vlad‐Andrei , Zengin‐Karaibrahimoglu Yasemin 
Published: July 2023

AbstractResearch SummaryGiven the growing legitimacy of corporate social responsibility (CSR), many firms engage in symbolic communication to showcase CSR without undertaking commensurate substantive actions. This “CSR decoupling” can create a risk of perceived greenwashing, which, in turn, may negatively affect a firm's performance. In this study, we explore an unexamined antecedent of decoupling: interfirm affiliation. Specifically, we use the structure of Business Groups (BGs) to investigate CSR decoupling across rather than within firms. We find that apex firms within a group are more likely to engage in CSR decoupling compared with non‐apex firms and, importantly, are partially shielded from greenwashing perceptions by the market. Our research contributes to the literatures on decoupling, perceived greenwashing, and the role of BGs and their CSR practices.Managerial SummaryCompanies that engage in symbolic communication about corporate social responsibility (CSR) without substantive actions risk being perceived as “greenwashers,” a perception that harms firm performance. Our study demonstrates how, in certain contexts where firms are affiliated with others, this may not occur. For instance, apex firms within Business Groups (BGs)—where firms are interconnected through equity and social relationships—can report on the CSR actions of non‐apex affiliates without providing commensurate substantive actions of their own. Importantly, the control and coordination abilities of these apex firms protect them from greenwashing perceptions. This study, therefore, demonstrates the role of BGs in shaping CSR practices and provides insights for managers to understand the potential risks and benefits of affiliations within BGs.
Integration of single‐cell transcriptome and proteome technologies: Toward spatial resolution levels
Authors: He Liyong , Wang Wenjia , Dang Kaitong , Ge Qinyu , Zhao Xiangwei 
Published: July 2023

AbstractCells are basic building blocks of life with vast heterogeneity. Nowadays, the rapid development of single‐cell multiomics (scMulti‐Omics) has facilitated comprehensive understanding of gene regulatory networks, cellular characteristics, and temporal dynamics. However, simultaneous analysis of transcriptome and proteome at single‐cell level still faces huge challenges due to their differences in molecular modalities. Recent technological advances in single‐cell manipulations, barcoding, and ultrasensitive instrument recently offer unprecedented opportunities for the co‐profiling of genes and proteins. In this review, multiple types of single‐cell isolation, lysis, and molecular separation technologies are first introduced. Second, various approaches for co‐measurement of transcriptome and proteome in single‐cells are summarized, with their advantages, limitations, and capacity for targeted or unbiased deep analysis. Then we highlight the cutting‐edge spatial multiomics methodologies that operate at the single‐cell or subcellular resolution level, providing a comprehensive understanding of cell function and heterogeneity within the tissue spatial environment. The emerging biomedical applications of multiomics are also discussed. Finally, the challenges and prospects of this field are proposed.
Hitting the mark: Localization of mRNA and biomolecular condensates in health and disease
Authors: Otis Jessica P. , Mowry Kimberly L. 
Published: July 2023

AbstractSubcellular mRNA localization is critical to a multitude of biological processes such as development of cellular polarity, embryogenesis, tissue differentiation, protein complex formation, cell migration, and rapid responses to environmental stimuli and synaptic depolarization. Our understanding of the mechanisms of mRNA localization must now be revised to include formation and trafficking of biomolecular condensates, as several biomolecular condensates that transport and localize mRNA have recently been discovered. Disruptions in mRNA localization can have catastrophic effects on developmental processes and biomolecular condensate biology and have been shown to contribute to diverse diseases. A fundamental understanding of mRNA localization is essential to understanding how aberrations in this biology contribute the etiology of numerous cancers though support of cancer cell migration and biomolecular condensate dysregulation, as well as many neurodegenerative diseases, through misregulation of mRNA localization and biomolecular condensate biology.This article is categorized under:
RNA Export and Localization > RNA Localization
RNA in Disease and Development > RNA in Disease
RNA in Disease and Development > RNA in Development
Large displacements and rotations of a local linear elastic rod
Authors: du Toit Sonja , Labuschagne Madelein , van der Merwe Alna 
Published: July 2023

AbstractThe Local Linear Timoshenko (LLT) model for the planar motion of a rod that undergoes flexure, shear and extension, was recently derived in Van Rensburg et al. (2021). In this paper we present an algorithm developed for this model. The algorithm is based on the mixed finite element method, and projections into finite dimensional subspaces are used for dealing with nonlinear forces and moments. The algorithm is used for an investigation into elastic waves propagated in the LLT rod. Interesting properties of the LLT rod include the increased propagation speed of elastic waves when compared to the linear Timoshenko beam, and the appearance of buckled states or equilibrium solutions for compressed LLT beams. It is also shown that the LLT rod is applicable to large displacements and rotations for a wide range of slender elastic objects; from beams to highly slender flexible rods.
PCL retention demonstrates better functional scores and gait patterns in total knee arthroplasty using a medial congruent insert—a prospective study
Authors: Rajgopal Ashok , Kumar Sumit , Singh Manish Kumar , Aggarwal Kalpana 
Published: July 2023

AbstractPurposeDespite Total Knee Arthroplasty (TKA) being one of the most successful procedures for end stage arthritis, nearly 20% of patients undergoing this procedure remain dissatisfied. Various design options have been introduced to reduce this cohort of patients. One such option has been the introduction of the medial congruent (MC) polyethylene design. This study was undertaken to evaluate outcome measures and gait analysis in patients undergoing bilateral single stage TKA where the posterior cruciate ligament (PCL) was retained or excised in contralateral knees.
Methods60 bilateral TKA’s were performed by a single surgeon using a MC design option from July to Sep 2021. The study lots included patients between the ages of 55 and 70 years with fixed varus deformity of degenerative aetiology, and Kellgren Lawrence Grade 3 and 4 radiological changes. Exclusion criteria were previous surgery to the lower extremities, sero positive arthropathies, post traumatic arthritis, valgus deformity, flexion contractures > 20°, and any pre‐existing pathology impacting gait, e.g., poliomyelitis, or neuromuscular disorders. The PCL was retained or sacrificed on contralateral sides for the purpose of this study. Functional scores, outcomes and gait analysis on level and gradient walking were evaluated at a follow‐up of 18 months.
ResultsAt 18, months the Range of Motion (ROM) improved from a preoperative value of 97.3 ± 11.5 to 110.3 ± 6.1 on the PCL retained side (MC‐PCL) and from 96.5 ± 10.8 to 113 ± 5.8 on the PCL excised side (MC‐PCLX). Knee Society Score (KSS‐2011) improved from a preoperative value of 21.2 ± 4.5 to 89.8 ± 3.4 at 18 months postoperatively on the MC‐PCL side and from 21.5 ± 4 to 88.2 ± 3.7 on the MC‐PCLX side. Forgotten Joint Score (FJS‐12) was 8.8 ± 0.7 on the MC‐PCL side and 8.1 ± 0.9 on the MC‐PCLX side 18 months after surgery. Our gait analysis evaluation demonstrated a lower forefoot pressure in the MC‐PCL group in comparison to the MC‐PCLX group when subjects were made to walk on a 30° upward incline. This difference was found to be statistically significant.
ConclusionIn this study, while ROM was greater in the MC‐PCLX study lot, patient satisfaction was higher in the MC‐PCL study lot. Gait assessment demonstrated lower forefoot pressure while ascending an incline of 30° in the MC‐PCL study lot as compared to the MC‐PCLX study lot approximating normal gait patterns.Level of evidenceII.
A Metagenomic Time-Series Approach to Assess the Ecological Stability of Microbial Mats in a Seasonally Fluctuating Environment
Authors: Madrigal-Trejo David , Sánchez-Pérez Jazmín , Espinosa-Asuar Laura , Valdivia-Anistro Jorge A. , Eguiarte Luis E. , Souza Valeria 
Published: July 2023

AbstractMicrobial mats are complex ecological assemblages that have been present in the rock record since the Precambrian and can still be found in extant marginalized environments. These structures are considered highly stable ecosystems. In this study, we evaluate the ecological stability of dome-forming microbial mats in a modern, water-level fluctuating, hypersaline pond located in the Cuatro Ciénegas Basin, Mexico. We conducted metagenomic sampling of the site from 2016 to 2019 and detected 2250 genera of Bacteria and Archaea, with only <20 belonging to the abundant taxa (>1%). The microbial community was dominated by Proteobacteria, Euryarchaeota, Bacteroidetes, Firmicutes, and Cyanobacteria, and was compositionally sensitive to disturbances, leading to high taxonomic replacement even at the phylum level, with a significant increase in Archaea from$$\sim $$∼1-4% to$$\sim $$∼33% throughout the 2016-2019 study period. Although a core community represented most of the microbial community (>75%), relative abundances shifted significantly between samples, as demonstrated by changes in the abundance ofColeofasciculusfrom 10.2% in 2017 to 0.05% in 2019. Although functional differences between seasons were subtle, co-occurrence networks suggest differential ecological interactions between the seasons, with the addition of a new module during the rainy season and the potential shift in hub taxa. Functional composition was slightly more similar between samples, but basic processes such as carbohydrate, amino acid, and nucleic acid metabolisms were widely distributed among samples. Major carbon fixation processes included sulfur oxidation, nitrogen fixation, and photosynthesis (both oxygenic and anoxygenic), as well as the Wood-Ljundgahl and Calvin cycles.
Phase I study to assess the effect of adavosertib (AZD1775) on the pharmacokinetics of substrates of CYP1A2, CYP2C19, and CYP3A in patients with advanced solid tumors
Authors: Någård Mats , Ah-See Mei-Lin , Strauss James , Wise-Draper Trisha , Safran Howard P. , Nadeau Laura , Edenfield William J. , Lewis Lionel D. , Ottesen Lone H. , Li Yan , Mugundu Ganesh M. 
Published: July 2023

Abstract
Purpose
Adavosertib may alter exposure to substrates of the cytochrome P450 (CYP) family of enzymes. This study assessed its effect on the pharmacokinetics of a cocktail of probe substrates for CYP3A (midazolam), CYP2C19 (omeprazole), and CYP1A2 (caffeine).

Methods
Period 1: patients with locally advanced or metastatic solid tumors received ‘cocktail’: caffeine 200 mg, omeprazole 20 mg, and midazolam 2 mg (single dose); period 2: after 7- to 14-day washout, patients received adavosertib 225 mg twice daily on days 1–3 (five doses), with cocktail on day 3. After cocktail alone or in combination with adavosertib administration, 24-h pharmacokinetic sampling occurred for probe substrates and their respective metabolites paraxanthine, 5-hydroxyomeprazole (5-HO), and 1′-hydroxymidazolam (1′-HM). Safety was assessed throughout.

Results
Of 33 patients (median age 60.0 years, range 41–83) receiving cocktail, 30 received adavosertib. Adavosertib co-administration increased caffeine, omeprazole, and midazolam exposure by 49%, 80%, and 55% (AUC0–12), respectively; AUC0–t increased by 61%, 98%, and 55%. Maximum plasma drug concentration (Cmax) increased by 4%, 46%, and 39%. Adavosertib co-administration increased 5-HO and 1′-HM exposure by 43% and 54% (AUC0–12) and 49% and 58% (AUC0–t), respectively; paraxanthine exposure was unchanged. Adavosertib co-administration decreased Cmax for paraxanthine and 5–HO by 19% and 7%; Cmax increased by 33% for 1′-HM. After receiving adavosertib, 19 (63%) patients had treatment-related adverse events (six [20%] grade ≥ 3).

Conclusion
Adavosertib (225 mg bid) is a weak inhibitor of CYP1A2, CYP2C19, and CYP3A.

ClinicalTrials.gov
NCT03333824
Pre- and post-diagnostic dairy intake in relation to recurrence and all-cause mortality in people with stage I-III colorectal cancer
Authors: van Lanen Anne-Sophie , Kok Dieuwertje E. , Wesselink Evertine , Winkels Renate M. , van Halteren Henk K. , de Wilt Johannes H. W. , Kampman Ellen , van Duijnhoven Fränzel J. B. 
Published: July 2023

Abstract
Purpose
Higher dairy consumption is associated with a lower risk of colorectal cancer (CRC), but no studies thus far have investigated its relation with recurrence in CRC. Few studies have investigated total dairy in relation to mortality in CRC, and yielded inconsistent results.

Methods
In this prospective cohort study, people newly diagnosed with stage I-III CRC filled out a food frequency questionnaire at diagnosis (n = 1812) and six months after diagnosis (n = 1672). We examined associations between pre- and post-diagnostic intake of total dairy, low-fat dairy, high-fat dairy, milk, yoghurt, and cheese with recurrence and all-cause mortality using multivariable Cox proportional hazard models and restricted cubic splines (RCS).

Results
A total of 176 recurrences and 301 deaths occurred during a median follow-up of 3.0 and 5.9 years, respectively. Before diagnosis, a higher low-fat dairy intake was associated with a lower risk of recurrence (HRQ4vsQ1: 0.42, 95% CI 0.26–0.67; PRCS: 0.008) and all-cause mortality (HRQ4vsQ1: 0.58, 95% CI 0.41–0.81; PRCS < 0.001), whereas a higher high-fat dairy consumption tended to be associated with an increased all-cause mortality risk (HRQ4vsQ1: 1.41, 95% CI 0.98–2.01; PRCS: 0.030). After diagnosis, only the associations between low- and high-fat dairy in relation to all-cause mortality remained.

Conclusions
This study demonstrated that higher pre- and post-diagnostic intakes of low-fat dairy were associated with a reduced all-cause mortality risk in people with stage I-III CRC, whereas higher intakes of high-fat dairy were associated with an increased all-cause mortality risk. Also, a higher pre-diagnostic low-fat dairy intake was associated with a reduced risk of recurrence.

Trial registration
Clinical Trials.gov identifier: NCT03191110.
Systematic review of imaging comparisons of spinal alignment among standing positions in healthy adolescents or adolescents with idiopathic scoliosis: SOSORT 2023 award winner
Authors: Fehr Brianna J. , Visser Annika , Parent Eric C. 
Published: July 2023

Abstract
Purpose
Clinicians detect scoliosis worsening over time using frequent radiographs during growth. Arms must be elevated when capturing sagittal radiographs to visualize the vertebrae, and this may affect the sagittal angles. The aim was to systematically review the published evidence of the effect of arm positions used during radiography on spinal alignment parameters in healthy participants and those with AIS.

Methods
Design was registered in PROSPERO (CRD42022347494). A search strategy was run in Medline, Embase, CINAHL, and Web of Science. Healthy participants ≥ 10 years old and participants with AIS between 10 and 18 years old, with Cobb angles > 10° were included. Study quality was assessed using the Appraisal tool for Cross-Sectional Studies (AXIS). Meta-analysis was performed where possible.

Results
Overall, 1332 abstracts and 33 full texts were screened. Data was extracted from 7 included studies. The most common positions were habitual standing, fists on clavicle, and active (arms raised unsupported). Kyphosis, lordosis, and sagittal vertical axis (SVA) were most measured. Meta-analysis showed significantly decreased kyphosis (SMD = 0.78, 95%CI 0.48, 1.09) and increased lordosis (SMD = − 1.21, 95%CI − 1.58, − 0.85) when clavicle was compared to standing. Significant posterior shifts in SVA were shown in clavicle compared to standing (MD = 30.59 mm, 95%CI 23.91, 37.27) and active compared to clavicle (MD = − 2.01 mm, 95%CI − 3.38, − 0.64). Cobb angles and rotation were rarely studied (1 study).

Conclusion
Meta-analysis evidence showed elevated arm positions modify sagittal measurements compared to standing. Most studies did not report on all relevant parameters. It is unclear which position best represent habitual standing.
Adherence to the Obeid coronal malalignment classification and a residual malalignment below 20 mm can improve surgical outcomes in adult spine deformity surgery
Authors: Baroncini Alice , Frechon Paul , Bourghli Anouar , Smith Justin S. , Larrieu Daniel , Pellisé Ferran , Pizones Javier , Kleinstueck Frank , Alanay Ahmet , Kieser David , Cawley Derek T. , Boissiere Louis , Obeid Ibrahim ,   the European Spine Study Group (ESSG)
Published: July 2023

Abstract
Purpose
Coronal balance is a major factor impacting the surgical outcomes in adult spinal deformity (ASD). The Obeid coronal malalignment (O-CM) classification has been proposed to improve the coronal alignment in ASD surgery. Aim of this study was to investigate whether a postoperative CM < 20 mm and adherence to the O-CM classification could improve surgical outcomes and decrease the rate of mechanical failure in a cohort of ASD patients.

Methods
Multicenter retrospective analysis of prospectively collected data on all ASD patients who underwent surgical management and had a preoperative CM > 20 mm and a 2-year follow-up. Patients were divided in two groups according to whether or not surgery had been performed in adherence to the guidelines of the O-CM classification and according to whether or not the residual CM was < 20 mm. The outcomes of interest were radiographic data, rate of mechanical complications and Patient-Reported Outcome Measures.

Results
At 2 years, adherence to the O-CM classification led to a lower rate of mechanical complications (40 vs. 60%). A coronal correction of the CM < 20 mm allowed for a significant improvement in SRS-22 and SF-36 scores and was associated with a 3.5 times greater odd of achieving the minimal clinical important difference for the SRS-22.

Conclusion
Adherence to the O-CM classification could reduce the risk of mechanic complications 2 years after ASD surgery. Patients with a residual CM < 20 mm showed better functional outcomes and a 3.5 times greater odd of achieving the MCID for the SRS-22 score.
How loss of tooth structure impacts the biomechanical behavior of a single-rooted maxillary premolar: FEA
Authors: Abdelfattah Roaa Abdelwahab , Nawar Nawar Naguib , Kataia Engy M. , Saber Shehabeldin Mohamed 
Published: July 2023

AbstractTo evaluate the influence of the loss of coronal and radicular tooth structure on the biomechanical behavior and fatigue life of an endodontically treated maxillary premolar with confluent root canals using finite element analysis (FEA). An extracted maxillary second premolar was scanned to produce intact (IT) 3D model. Models were designed with an occlusal conservative access cavity (CAC) with different coronal defects; mesial defect (MO CAC), occlusal, mesial and distal defect (MOD CAC), and 2 different root canal preparations (30/.04, and 40/.04) producing 6 experimental models. FEA was used to study each model. A simulation of cycling loading of 50N was applied occlusally to stimulate the normal masticatory force. Number of cycles till failure (NCF) was used to compare strength of different models and stress distribution patterns via von Mises (vM) and maximum principal stress (MPS). The IT model survived 1.5 × 1010 cycles before failure, the CAC-30.04 had the longest survival of 1.59 × 109, while the MOD CAC-40.04 had the shortest survival of 8.35 × 107 cycles till failure. vM stress analysis showed that stress magnitudes were impacted by the progressive loss of coronal tooth structure rather than the radicular structure. MPS analysis showed that significant loss of coronal tooth structure translates into more tensile stresses. Given the limited size of maxillary premolars, marginal ridges have a critical role in the biomechanical behavior of the tooth. Access cavity preparation has a much bigger impact than radicular preparation on their strength and life span.
Changes in over-winter prey availability, rather than winter climate, are associated with a long-term decline in a northern Tawny Owl population
Authors: Orlando Giuseppe , Passarotto Arianna , Morosinotto Chiara , Ahola Kari , Karstinen Teuvo , Brommer Jon E. , Koskenpato Katja , Karell Patrik 
Published: July 2023

AbstractAlthough the associations between climate, food conditions and reproduction in the wild has been the focus of numerous studies in recent years, we still know little about population level responses to climate and fluctuating food conditions in long-lived species and during longer periods of time. Here, we assessed the relative importance of the abundance of the main prey in winter (small mammals), and winter climate on population size and productivity in a Tawny Owl (Strix aluco) population in southern Finland during a 40-year period. We studied how population trends changed over time and in relation to winter weather and small mammal abundance on three levels: total estimated population size, proportion of breeders and population productivity. We identified declining trends in each population parameter over time, as well as directional changes in climate variables and prey abundance. Overall, small mammal abundance was the foremost predictor in explaining the variation in the number of active territorial pairs (population size). Moreover, both prey abundance and winter temperature significantly affected the proportion of territorial pairs that attempted to breed and thereby total offspring production, which reveals the relevance of winter weather conditions for population productivity. These results provide additional support to the view that changes in climate can modify predator–prey interactions leading to functional changes in the food web.