bluuebunny/crossref_metadata_2025_split huggingface dataset:
VISITOR: Visual Interactive State Sequence Exploration for Reinforcement Learning
Authors: Metz Yannick , Bykovets Eugene , Joos Lucas , Keim Daniel , El‐Assady Mennatallah 
Published: June 2023

AbstractUnderstanding the behavior of deep reinforcement learning agents is a crucial requirement throughout their development. Existing work has addressed the identification of observable behavioral patterns in state sequences or analysis of isolated internal representations; however, the overall decision‐making of deep‐learning RL agents remains opaque. To tackle this, we present VISITOR, a visual analytics system enabling the analysis of entire state sequences, the diagnosis of singular predictions, and the comparison between agents. A sequence embedding view enables the multiscale analysis of state sequences, utilizing custom embedding techniques for a stable spatialization of the observations and internal states. We provide multiple layers: (1) a state space embedding, highlighting different groups of states inside the state‐action sequences, (2) a trajectory view, emphasizing decision points, (3) a network activation mapping, visualizing the relationship between observations and network activations, (4) a transition embedding, enabling the analysis of state‐to‐state transitions. The embedding view is accompanied by an interactive reward view that captures the temporal development of metrics, which can be linked directly to states in the embedding. Lastly, a model list allows for the quick comparison of models across multiple metrics. Annotations can be exported to communicate results to different audiences. Our two‐stage evaluation with eight experts confirms the effectiveness in identifying states of interest, comparing the quality of policies, and reasoning about the internal decision‐making processes.
Improved serologic responses to DTaP over Tdap vaccination in adult hematopoietic cell transplant recipients
Authors: Xu Bolong , Gordillo Christian A. , Delille Elsa M. , Malandrakis Stephanie , Assal Amer , Mapara Markus Y. , Reshef Ran 
Published: June 2023

AbstractBackgroundHematopoietic cell transplantation (HCT) recipients have reduced antibody titers to tetanus, diphtheria, and pertussis. Tdap is approved for revaccinating adult HCT recipients in the United States, whereas DTaP is not approved in this population. To our knowledge, no studies to date have compared responses to DTaP versus Tdap in adult HCT patients. We conducted a retrospective study comparing responses to DTaP versus Tdap vaccines in otherwise similar adult HCT patients in order to determine if one of these vaccines elicits superior antibody responses.MethodsWe evaluated 43 allogeneic and autologous transplant recipients as a combined cohort and as separate subsets for vaccine specific antibody titers and proportion of strong vaccine responders. Subset analysis focused on the autologous transplant recipients.ResultsHigher median antibody titers were found to all vaccine components among DTaP recipients (diphtheria p = .021, pertussis p = .020, tetanus p = .007). DTaP recipients also had more strong responders to diphtheria and pertussis (diphtheria p = .002, pertussis p = .006). Among the autologous HCT recipient subset, there were more strong responders to diphtheria (p = .036).ConclusionsOur data shows that post‐HCT vaccination with DTaP leads to higher antibody titers and more strong responders, which suggests that DTaP is more effective than Tdap in HCT recipients.
Tropical dry woodland loss occurs disproportionately in areas of highest conservation value
Authors: Buchadas Ana , Jung Martin , Bustamante Mercedes , Fernández‐Llamazares Álvaro , Garnett Stephen T. , Nanni Ana Sofía , Ribeiro Natasha , Meyfroidt Patrick , Kuemmerle Tobias 
Published: June 2023

AbstractTropical and subtropical dry woodlands are rich in biodiversity and carbon. Yet, many of these woodlands are under high deforestation pressure and remain weakly protected. Here, we assessed how deforestation dynamics relate to areas of woodland protection and to conservation priorities across the world's tropical dry woodlands. Specifically, we characterized different types of deforestation frontier from 2000 to 2020 and compared them to protected areas (PAs), Indigenous Peoples' lands and conservation areas for biodiversity, carbon and water. We found that global conservation priorities were always overrepresented in tropical dry woodlands compared to the rest of the globe (between 4% and 96% more than expected, depending on the type of conservation priority). Moreover, about 41% of all dry woodlands were characterized as deforestation frontiers, and these frontiers have been falling disproportionately in areas with important regional (i.e. tropical dry woodland) conservation assets. While deforestation frontiers were identified within all tropical dry woodland classes of woodland protection, they were lower than the average within protected areas coinciding with Indigenous Peoples' lands (23%), and within other PAs (28%). However, within PAs, deforestation frontiers have also been disproportionately affecting regional conservation assets. Many emerging deforestation frontiers were identified outside but close to PAs, highlighting a growing threat that the conserved areas of dry woodland will become isolated. Understanding how deforestation frontiers coincide with major types of current woodland protection can help target context‐specific conservation policies and interventions to tropical dry woodland conservation assets (e.g. PAs in which deforestation is rampant require stronger enforcement, inactive deforestation frontiers could benefit from restoration). Our analyses also identify recurring patterns that can be used to test the transferability of governance approaches and promote learning across social–ecological contexts.
Sublethal consequences of ultraviolet radiation exposure on vertebrates: Synthesis through meta‐analysis
Authors: Downie Adam T. , Wu Nicholas C. , Cramp Rebecca L. , Franklin Craig E. 
Published: June 2023

AbstractUltraviolet radiation (UVR) from the sun is a natural daytime stressor for vertebrates in both terrestrial and aquatic ecosystems. UVR effects on the physiology of vertebrates manifest at the cellular level, but have bottom‐up effects at the tissue level and on whole‐animal performance and behaviours. Climate change and habitat loss (i.e. loss of shelter from UVR) could interact with and exacerbate the genotoxic and cytotoxic impacts of UVR on vertebrates. Therefore, it is important to understand the range and magnitude of effects that UVR can have on a diversity of physiological metrics, and how these may be shaped by taxa, life stage or geographical range in the major vertebrate groups. Using a meta‐analytical approach, we used 895 observations from 47 different vertebrate species (fish, amphibian, reptile and bird), and 51 physiological metrics (i.e. cellular, tissue and whole‐animal metrics), across 73 independent studies, to elucidate the general patterns of UVR effects on vertebrate physiology. We found that while UVR's impacts on vertebrates are generally negative, fish and amphibians were the most susceptible taxa, adult and larvae were the most susceptible life stages, and animals inhabiting temperate and tropical latitudes were the most susceptible to UVR stress. This information is critical to further our understanding of the adaptive capacity of vulnerable taxon to UVR stress, and the wide‐spread sublethal physiological effects of UVR on vertebrates, such as DNA damage and cellular stress, which may translate up to impaired growth and locomotor performance. These impairments to individual fitness highlighted by our study may potentially cause disruptions at the ecosystem scale, especially if the effects of this pervasive diurnal stressor are exacerbated by climate change and reduced refuge due to habitat loss and degradation. Therefore, conservation of habitats that provide refuge to UVR stress will be critical to mitigate stress from this pervasive daytime stressor.
Injection technique of the upper face with onabotulinumtoxinA in chronic migraine
Authors: Boczarska‐Jedynak Magdalena , Blumenfeld Andrew M. 
Published: June 2023

AbstractBackgroundThe objective is to review the technique of onabotulinumtoxinA injection treatment in the glabellar and frontal regions using the PREEMPT (Phase III REsearch Evaluating Migraine Prophylaxis Therapy) paradigm, with review of the aesthetic issues related to the procedure. OnabotulinumtoxinA is an effective medication for the prevention of chronic migraine. The PREEMPT injection paradigm has been validated in randomized clinical trials and real‐world settings. This treatment includes injections in the forehead and glabella area. In addition, for aesthetic uses, glabella onabotulinumtoxinA injections are done in similar muscles specifically the procerus, corrugator supercilii, and frontalis muscles. Often patients who have been injected with onabotulinumtoxinA for chronic migraine have concerns about their appearance and will ask if they can see an aesthetic injector to improve this. This is a difficult issue as onabotulinumtoxinA should be injected with an interval of 10–12 weeks to avoid development of antibodies against onabotulinumtoxinA, so all injections (migraine and aesthetic) should ideally be done close together; however, if an aesthetic injection is done on the same day as a PREEMPT injection, the effect of the PREEMPT injection will not yet be visible as it takes time for onabotulinumtoxinA effects to be seen. Thus, there is a risk of a potential overdose in a particular area if aesthetic injections are done without input from the PREEMPT injector.MethodsThis is a narrative review supported by photographic documentation showing the technique of onabotulinumtoxinA injection of the upper face, considering anatomical differences between patients, and combining the needs in neurology and aesthetic medicine fields.ResultsPractitioners treating chronic migraine often modify some of the principles of the PREEMPT paradigm. Many practitioners are unsure about injections in the glabellar and frontal areas. The authors present a technique for using the PREEMPT protocol and adapting this to the individual patient's anatomy to prevent an unsightly appearance or ptosis. In addition, sites are provided where an aesthetic injector could inject to improve the patient's appearance without overlapping with the PREEMPT injection sites.ConclusionAdherence to the PREEMPT injection protocol provides an evidence‐based approach to achieving clinical benefit for patients with chronic migraine. Aesthetic elements of the treatment of the glabella and forehead require additional attention. The authors provide practical considerations and recommendations regarding this.
Microwave absorption properties of (1 − x)La0.85Ag0.15MnO3/x graphene (x = 0, 3, and 5 wt.%) composites
Authors: Apandi Nur Ain Athirah , Ibrahim Norazila Binti , Khan Zuhani Ismail , Azis Rabaah Syahidah 
Published: June 2023

AbstractComposite of (1 − x)La0.85Ag0.15MnO3/x graphene (x = 0, 3, and 5 wt.%) and epoxy resin with a ratio of 4:1 were prepared to investigate the influence of the addition of graphene in (1 − x)La0.85Ag0.15MnO3/x graphene on real and imaginary parts of permittivity, permeability, as well as microwave reflection loss (RL), using a vector network analyzer in the 8–18 GHz of the frequency range. It is found that the value of RL is smaller at x = 3 wt.% (−20.74 dB at 14.85 GHz) and 5 wt.% (−14.81 at 16.50 GHz) compared to at x = 0 wt.% (−8.89 dB at 15.90 GHz). The result indicates that microwave absorption properties significantly improved as a result of the addition of graphene. It is suggested that the addition of graphene enhanced the dielectric loss–related mechanism such as interfacial polarization and conduction loss resulting in an improvement of microwave absorption performance for both x = 3 wt.% and x = 5 wt.% samples. It also shows that the observed enhanced microwave absorption properties may also be influenced by the resistivity of the sample as x = 3 wt.% sample exhibits enhanced microwave absorption properties and the lowest resistivity among the studied samples.
A comparative study on the physicochemical characteristics and protein digestibility of tofu induced by magnesium chloride or combined with transglutaminase
Authors: Tang Ting , Shi Yifan , Yang Siran , Li Jikeyi , Chen Jiaying , Wu Xiaoqin , Xing Guangliang 
Published: June 2023

SummaryIn this study, tofu was prepared through the addition of transglutaminase (TGase) for pre‐crosslinking at varying durations (1, 2 and 3 h), followed by the addition of magnesium chloride (MgCl2) to soymilk. The physicochemical properties and protein digestibility were analysed. Results indicated that, with the prolongation of TGase pre‐crosslinking time, the zeta‐potential absolute value and the average particle size of soymilk increased gradually. In contrast, the pH value remained unchanged (P > 0.05), suggesting that the colloidal stability of soymilk improved with TGase treatment. Both the water‐holding capacity (WHC) and gel strength of tofu gels exhibited a first increasing and then decreasing trend with prolonged pre‐crosslinking time. Notably, the highest WHC and hardness values of tofu gels prepared by adding MgCl2 after pre‐crosslinking with TGase for 1 h were 96.5 ± 0.5% and 363.9 ± 28.3 g, respectively. Subsequently, in vitro simulated gastrointestinal digestion of tofu samples prepared under this condition was conducted to determine changes in soluble protein content, small peptide content and protein hydrolysis spectrum. Gastric and intestinal digestion phases were the primary stages of protein hydrolysis, and the bioavailability of proteins in TGase+MgCl2‐induced tofu was higher than in MgCl2‐coagulated tofu. Therefore, tofu prepared through TGase pre‐treatment was more conducive to soybean protein digestion and absorption.
Does primary urethral realignment improve the outcome of pediatric pelvic fracture urethral injury? A randomized controlled trial
Authors: Taha Taha M. , Ali Mohamed O. , Shahat Ahmed A. , Abdalla Medhat A. , Hammouda Hisham M. , Behnsawy Hosny M. 
Published: June 2023

ObjectiveTo assess the efficacy of primary urethral realignment in the prevention of urethral stenosis and in simplifying delayed urethroplasty after complete pelvic fracture urethral injury in male children.MethodsThis randomized comparative trial included 40 boys <18 years with complete pelvic fracture urethral injury. The initial management was a primary urethral realignment in 20 boys and suprapubic cystostomy alone in the remaining 20 boys. The boys who underwent primary urethral realignment were assessed regarding the development of urethral stenosis. Boys who needed to be delayed urethroplasty in the two groups were compared regarding urethral defect length, intraoperative details, postoperative outcomes, number of procedures, and time to achieve normal voiding.ResultsAlthough 14 (70%) patients were able to void after primary urethral realignment, all of them developed urethral stenosis and needed delayed urethroplasty. No statistically significant difference between the two groups was found regarding urethral defect length, intraoperative details, and postoperative outcomes. Patients in the primary urethral realignment group underwent significantly more procedures (p < 0.001) and took a significantly longer time to achieve normal voiding (p = 0.002).ConclusionPrimary urethral realignment is neither able to prevent urethral stenosis nor effective in simplifying later urethroplasty after complete pelvic fracture urethral injury in male children. It exposes the patients to more surgical procedures and a prolonged clinical course.
A feasibility study of urinary catheter removal protocol following transurethral prostatectomy procedure in older patients
Authors: Pan Jin‐Hua , Tsai Yuh‐Shyan , Cheng Yu‐Sheng , Chang Chia‐Ming , Wang Kuei‐Ying , Hu Fang‐Wen 
Published: June 2023

AbstractWe hypothesized that older patients who underwent a urinary catheter removal protocol would not have an increased risk of postoperative complications. We further hypothesized that the revised protocol would be more suitable for clinical application. This study aimed to develop a urinary catheter removal protocol after Transurethral Resection of the Prostate and to assess the feasibility of the protocol to support catheter removal and promote recovery of self‐voiding function. Delayed catheter removal after Transurethral Resection of the Prostate was associated with urinary tract infection and longer hospital stays. However, no strategy has been described to promote recovery of self‐voiding function after catheter removal after Transurethral Resection of the Prostate. The urinary catheter removal protocol was developed through expert consensus, including strategies for caring for urinary catheters, assessment of urinary catheter removal, and strategies after urinary catheter removal. Moreover, a quasi‐experimental design was adopted in the urology ward of a tertiary care medical centre in southern Taiwan. Patients aged ≥65 years who underwent Transurethral Resection of the Prostate were included. A total of 13 patients (intervention = 5; control = 8) were included in the feasibility evaluation. A urinary catheter removal protocol after Transurethral Resection of the Prostate was developed and the consensus among experts on the urinary catheter removal protocol was 99%. There were no significant differences in terms of bleeding, urine retention, urinary tract infection, or re‐catheterization between the two groups. However, in the intervention group, the pain score decreased significantly on the second day after Transurethral Resection of the Prostate. This revised urinary catheter removal protocol after Transurethral Resection of the Prostate may be suitable for clinical applications. However, small size reduces the statistical power of the findings and further studies are needed to examine the current protocol does not have an increased risk of postoperative complications.
The effect of education given to university students on health beliefs and testicular self‐examination
Authors: Saygili Duzova Ulku , Duzova Mursel , Golcur Gorkem , Arıcı Emin , Idin Muhammed 
Published: June 2023

AbstractThis research aims to evaluate the effect of group‐oriented peer education given to university students with testicular cancer on health beliefs and self‐examination. Is there a statistical difference in the average of health belief points of university students before education compared to after education? Testicular cancer is one of the most common cancers in young men aged 0–34 years, and is the third most common cancer in men worldwide. It ranks first among the most common types of cancer in men of the same age in Turkey. This research is a semi‐experimental quantitative study with a single group pre‐test and post‐test design. The students of the health care services and therapy rehabilitation department of a Turkish state university participated in the study. The number of students to be included in the study was determined as n = 78 when the calculation was made according to the sample selection formula for the group whose universe was known. Data were obtained from the personal information form, the testicular cancer and testicular self‐examination‐related health beliefs scale, and the self‐examination form. This study followed the ethical directions of the Helsinki Declaration. Ethics committee approval and institutional permission were obtained before the study was conducted. The students were informed about the purpose of the research, and their consent was obtained to participate in the research. Mann–Whitney U, Wilcoxon, and chi‐square analyses were performed for data analysis. A significant difference was found between pre‐test and post‐test scores of severity and care, benefit and health motivation, barriers, and self‐efficacy (p < 0.05). In the study, it was determined that group‐oriented peer education was effective in promoting testicular self‐examination. Experimental studies with larger study groups are recommended to increase testicular self‐examination. Practice educational initiatives should be planned to encourage nurses to perform testicular self‐exam in the best environment and education model where they can reach men in the risk group between the ages of 15–25 organization of planned trainings for men. This study is the small sample size. A larger and more representative sample of students from the social and health departments of different faculties would have provided more reliable results.
Nasal shedding of vaccine viruses after immunization with a Russian‐backbone live attenuated influenza vaccine in India
Authors: Dar Lalit , Krishnan Anand , Kumar Ramesh , Dhakad Shivram , Choudekar Avinash , Bagga Sumedha , Sharma Amrit , Kumar Amit , Jethani Jyoti , Saha Siddhartha , Amarchand Ritvik , Kumar Rakesh , Choudhary Aashish , Narayan Venkatesh Vinayak , Gopal Giridara , Lafond Kathryn E. , Lindstrom Stephen 
Published: June 2023

AbstractBackgroundWe present post‐vaccination nasal shedding findings from the phase IV, community‐based, triple‐blinded RCT conducted to assess efficacy of trivalent LAIV and inactivated influenza vaccines in rural north India.MethodsChildren aged 2–10 years received LAIV or intranasal placebo across 2015 and 2016, as per initial allocation. On days 2 and 4 post‐vaccination, trained study nurses collected nasal swabs from randomly selected subset of trial participants based on operational feasibility, accounting for 10.0% and 11.4% of enrolled participants in 2015 and 2016, respectively. Swabs were collected in viral transport medium and transported under cold chain to laboratory for testing by reverse transcriptase real‐time polymerase chain reaction.ResultsIn year 1, on day 2 post‐vaccination, 71.2% (74/104) of LAIV recipients shed at least one of vaccine virus strains compared to 42.3% (44/104) on day 4. During year 1, on day 2 post‐vaccination, LAIV‐A(H1N1)pdm09 was detected in nasal swabs of 12% LAIV recipients, LAIV‐A(H3N2) in 41%, and LAIV‐B in 59%. In year 2, virus shedding was substantially lower; 29.6% (32/108) of LAIV recipients shed one of the vaccine virus strains on day 2 compared to 21.3% on day 4 (23/108).ConclusionAt day 2 post‐vaccination in year 1, two‐thirds of LAIV recipients were shedding vaccine viruses. Shedding of vaccine viruses varied between strains and was lower in year 2. More research is needed to determine the reason for lower virus shedding and vaccine efficacy for LAIV‐A(H1N1)pdm09.