bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rate of Canine Retraction and Expression of Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) and Osteoprotegerin (OPG) in Gingival Crevicular Fluid (GCF) Following the Placement of Autologous Leukocyte-Platelet Rich Fibrin (L-PRF) Among Subjects with Class I Bimaxillary Protrusion Malocclusions: A Split-Mouth Randomized Controlled Trial
Authors: Balarama Krishna V. , Isha Duggal , Jitendra Sharan , Manaswini Mangaraj , Ritu Duggal , Kumar Jena Ashok 
Published: February 2023

Abstract
Objectives: To assess the outcome of L-PRF on the rate of maxillary canine retraction and its correlation with the levels of RANKL and OPG in the GCF.
Subjects and Methods: Eighteen females who required all 1st premolars extraction for the correction of their Class-I bimaxillary protrusion malocclusions were included. The L-PRF plugs were placed in the experimental side 1st premolar extraction sockets. Canine retraction was performed by sliding mechanics. Canine retraction was assessed from the maxillary study models prepared just before the extraction (T0), then at 1-week (T1), 2-weeks (T2), 4-weeks (T3), and 8-weeks (T4) after the 1st premolars extraction and placement of L-PRF plugs. The concentrations of RANKL and OPG in the GCF were evaluated at T0, T1, T2, T3 and T4.
Results: In experimental sides, the amount of canine retraction was statistically more during the T0-T1 (P=0.035), T1-T2 (P=0.001), and T2-T3 (P=0.038) periods. The mean concentration of RANKL at T1 (P=0.001), T2 (P=0.002) and T3 (P=0.010) was significantly more in the experimental sides. The mean concentration of OPG was significantly less in the experimental sides at T2 (P=0.016), T3 (P=0.020) and T4 (P=0.023). The RANKL:OPG was significantly more in the experimental sides at T1 (P=0.002), T2 (P=0.001), T3 (P=0.001) and T4 (P=0.005). No significant correlation found between canine retraction and RANKL and OPG concentrations in GCF.
Conclusions: The L-PRF accelerated the rate of maxillary canine retraction by 0.28mm over 8-weeks period. The L-PRF favored the local osteoclastogenesis by enhancing the RANKL and suppressing the OPG concentrations.
Trial registration: The Clinical Trials Registry of India (Reg. No. CTRI/2020/10/028390, Date-13.10.2020).
Etoposide/platinum plus anlotinib for patients with transformed small-cell lung cancer from EGFR-mutant lung adenocarcinoma after EGFR-TKI resistance: A retrospective and observational study
Authors: Ding Jianghua , Leng Zhaohui , Gu Hong , Jing Xiang , Song Yun 
Published: February 2023

Abstract
Objective: The histological conversion of lung adenocarcinoma (LUAD) into small-cell lung cancer (SCLC) is an important resistance mechanism for epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-resistant LUAD. Anlotinib has been recommended as the third-line treatment for SCLC patients. The efficacy of etoposide/platinum (EP) as the main treatment is very limited for patients with transformed SCLC. However, little is known about EP plus anlotinib for transformed SCLC. The present study retrospectively explored the clinical response to EP combined with anlotinib in patients with transformed SCLC from LUAD after EGFR-TKI failure.
Methods: A total of 10 patients who underwent SCLC transformation from EGFR-TKI-resistant LUAD were retrospectively reviewed from September 1, 2019, to December 31, 2022, in three regional hospitals. All of the patients were treated with the combination regimen of EP and anlotinib for four to six cycles, followed by anlotinib maintenance therapy. The clinical efficacy indices including objective response rate (ORR), disease control rate (DCR), median progression-free survival (mPFS), median overall survival (mOS), and toxicities were evaluated.
Results: The median time from EGFR-TKI treatment to SCLC conversion was 20.1±2.76 months (17–24 months). Genetic examination after transformation showed that 90% of the patients retained their original EGFR gene mutations. Additional driver genes included BRAF mutation (10%), PIK3CA mutation (20%), RB1 loss (50%), and TP53 mutation (60%). The ORR and DCR were 80% and 100%, respectively. The mPFS was 9.0 months (95% CI, 7.9–10.1 months), and the mOS was 14.0 months (95% CI, 12.0–15.9 months). Less than 10% of grade 3 toxicities were observed, and no grade 4 toxicity and death events were reported.
Conclusion: The EP plus anlotinib regimen appears to be a promising and safe strategy in transformed SCLC patients after EGFR-TKI resistance, which warrants further investigation.
Cost effective production of Bacillus thuringiensis israelensis using rotten Pineapples
Authors: C Gopinathan , Shaju Devika M , E Hana mol K 
Published: February 2023

Abstract
Vector-borne ailments are illnesses that are transmitted by way of vectors or insects, which consist of ticks, mosquitoes and fleas. These vectors can elevate infective pathogens such as viruses, bacteria and protozoa which can be transferred from one host (carrier) to another. For the prevention of these diseases, vector management could be a powerful preventive tool. Microbial insecticide most extensively used in the world are preparations of Bacillus thuringiensis (Bt). Bacillus thuringiensis israelensis (Bti) serving as an ideal candidate for mosquito control due to the fact of its excessive mosquito larvicidal activity, environmental friendliness, safety to non-target organisms and mammals, ease of production and ability to withstand various formulations like a dust, pellets, sprays, briquettes, capsules, granules, etc. Effect of submerged, solid state, batch and fed batch fermentation on the cultivation of Bti was investigated using rotten pineapple juice as substrate. Compared to batch fermentation, fixed volume fed-batch shows increase in biomass by 23.8%. 80% solid state fermentation showed maximum biomass among all the cultivation. Studies have been also conducted by using cheap industrial substrate together with chicken manure, fish waste, urea and soybean powder as nitrogenous sources which will greatly help in cutting down production cost of Bti for bulk production. Finally, biolarvicidal activity of the Bti were also evaluated using Aedes aegypti. 70–98% mortality was observed in PEP media supplemented with different nitrogenous wastes.
Antibacterial Activity of Pigment Extracted from Pigment Producing Bacteria
Authors: Chaturwedi Shashi Bhushan , Mainali Swostika , Chaudhary Richa 
Published: February 2023

Abstract
The purpose of this study was to evaluate antibacterial activity of pigment extracted from pigment producing bacteria isolated from soil samples. During the study, 20 soil samples were collected from different areas (forest, agriculture fields, river sides and dumping sites) of Kathmandu and Lalitpur districts which were processed for isolation of pigment producing bacteria by serial dilution and spread plate technique. The pigmented bacterial isolates were identified and enriched in nutrient broth. Then, pigment was extracted in 95% methanol as solvent, which was further characterized using UV-Vis Spectrophotometric and TLC analysis. The obtained crude pigment extract were processed to carry out the antimicrobial susceptibility assay using agar well diffusion method. Out of 13 total pigmented bacteria isolates, four different colored pigmented bacterial isolates (S4O, S11Y, S14P and S17G) which produced efficient pigment on nutrient agar were chosen and they were further processed. Among these isolates, S4O was identified as Staphylococcus aureus, S11Y was identified as Micrococcus luteus, S14P was identified as Micrococcus roseus and S17G was identified as Pseudomonas aeruginosa respectively. On characterization using UV-Vis Spectrophotometric and TLC analysis, the pigment extracted from isolates S4O, S11Y and S14P were found to be Carotenoids and from isolate S17G was found to be Pyocyanin in nature. The maximum antibacterial activity was shown against Staphylococcus aureus from all the four pigments extracts. The green color pigment extract from isolate S17G was found to be most effective against all the Gram positive and Gram negative test bacteria. This study suggest that these pigment extracts from pigmented bacteria may have beneficial antibacterial roles that can be exploited in controlling unwanted bacterial growth.
Lie-series transformations and applications to construction of analytical solutions
Authors: Zhao Shunjing , Lei Hanlun 
Published: February 2023

Abstract
In this study, Lie-series transformations including Hori's, Deprit's and Dragt--Finn's are discussed and applied to construction of analytical solutions of invariant manifolds in the circular restricted three-body problem (CRTBP). It shows that three Lie-series transformations lead to the same Kamiltonian as well as the same expressions of analytical solutions, implying that these three transformations are equivalent from the viewpoint of constructing analytical solutions. By taking Lie-series transformations, two types of analytical solutions are formulated for invariant manifolds in terms of action--angle variables as well as motion amplitudes. To validate the Lie-series analytical solutions, analytical trajectories are compared with numerical ones, showing that the analytical solution with a higher order has a higher accuracy. Motivated by the fact that Dragt--Finn's recursion can be derived from Hori's transformation by ignoring the commutation relation of Poisson brackets, we propose a simplified version of Deprit's recursion. It is shown that the simplified Deprit's recursion is equivalent to the other three transformations. From the viewpoint of computational cost, the simplified Deprit's recursion and Dragt--Finn's transformation are preferred in practice because they have much smaller number of Poisson brackets than the other two transformations at high orders. At last, explicit expressions are provided for Dragt--Finn's and the simplified Deprit's recursions up to order 10.
A Comparative Clinical Study Between Allograft Putty and Customized Allograft Bone Blocks in Treatment of Third Molar Extraction Socket Defects for Mitigating Probing Depth and Clinical Attachment Loss
Authors: Attili Obada , Hamdoon Zaid , Abdul-Sattar Abier , Samsudin A. R. 
Published: February 2023

Abstract
Objectives The aim of this study was to evaluate changes in mean probing depth and clinical attachment level at disto-buccal aspect of adjacent mandibular second molar following removal of third molar after socket treatment with either allograft putty or customized allograft bone block.
Materials and Methods 30 patients underwent extraction of a lower mesio-angular impacted third molar; and they were divided into three treatment groups. Group 1 received allograft putty, and Group 2 received customized allograft bone block in the socket while patients in Control Group 3 did not receive any bone substitute. Probing depth and clinical attachment level at disto-buccal aspect of adjacent mandibular second molar was measured at 1 week, 3 months, 6 months and 12 months post-operative. Pain score and complications were assessed.
Results Reduction in probing depth over time between groups was not significant. Customized allograft bone block group showed higher clinical attachment loss compared to allograft putty treatment. Pain scores were significantly higher in both the intervention groups and post-operative complications were highest in the customized allograft bone block group.
Conclusions Socket preservation following third molar extraction using either allograft putty or customized allograft bone block did not show favorable results for mitigating postoperative probing depth and clinical attachment loss at disto-buccal aspect of adjacent second molar .
Clinical Relevance Augmentation of lower third molar extraction socket with bone allograft to mitigate probing depth and clinical attachment loss at adjacent second molar does not show favorable results compared to leaving the socket to heal alone.
Mapping specific habitat requirements as a base for conservation measures for two strongly endangered burnet moth species in Southern France: Zygaena brizae and Zygaena cynarae (Lepidoptera, Zygaenidae)
Authors: Hahn Inka , Wense-Goncalves Paulo , Brandmeier Melanie , Richaud Sonia , Markl Gregor 
Published: February 2023

Abstract
Zygaena species are sensitive indicators of ecological changes and habitat destruction. Here, field results on the ecology of two highly endangered species, Zygaena brizae and Zygaena cynarae, from optimal habitats near Col d'Araud in Hautes-Alpes, France are reported. Both species have faced severe population decline in the last decades in Southwest France, probably due to habitat deterioration. During May and June 2022, larvae, imagines and egg batches were mapped in carefully characterized habitat patches. In total, 713 imagines, 67 larvae and 20 egg batches of Zygaena cynarae (which was the most common burnet moth in the area in 2022) and 23 imagines, 84 larvae, 2 pupae and 18 egg batches of Zygaena brizae were observed. While Zygaena brizae occurs both on mesophile and on semi-dry slopes (only north-and west-facing), supported by increasing numbers of the larval food plant (Cirsium tuberosum), larval habitats of Zygaena cynarae are characterized by the common occurrence of the larval food plant (Peucedanum cervaria) and by (optimally) 10-30% tree cover. Most colonized patches are south-facing and flat; open habitat patches with many larval food plants are not inhabited. All inhabited patches are extensively grazed by sheep, goats, cattle or horses-the specifics do not seem to matter. Details of grazing schedule, sunshine duration, slope exposure and other habitat parameters are reported and evaluated to support conservation measures of these burnet moth species. Implications for insect conservation: Our results provide robust data about the specific habitat requirements of these two strongly endangered burnet moth species.
MAES: A ROS 2 Compatible Simulation Tool for Multi Robot Exploration and Coverage
Authors: Andreasen Malte Z. , Holler Philip I. , Jensen Magnus K. , Albano Michele 
Published: February 2023

Abstract
With the aim of allowing the realistic simulation of exploration and coverage algorithms, we present the tool Multi Agent Exploration Simulator (MAES), which is an open-source physics based discrete step multi robot simulator. MAES features movement in a continuous 2D space, realistic physics based on the Unity framework, advanced visualization techniques such as heatmaps, custom wireless signal degradation, both randomly generated and custom user-provided maps, and a ROS (Robot Operating System) interface. This latter characteristic allows to port easily the simulated algorithms to real world robots. We present performance tests, conducted with rather modest hardware, showing that MAES is able to simulate up to 5 robots in ROSMode (using the ROS integration) and up to 120 robots in UnityMode (development performed directly into the C# Unity Editor). A usability test was conducted which hinted that the target audience of robotics researchers and developers is able to quickly install, setup, and use MAES for implementing simple robot logic.
Early-warning evaluation of land ecosystem health in the Poyang lake eco-economic zone
Authors: Fu Yongqi , Wei Peng , Yu Dun 
Published: February 2023

Abstract
Frequent natural disasters and environmental pollution have posed a threat to the regional land ecosystem health (LEH) and hindered the regional economic development. Therefore, it is of great significance to study LEH. According to the dynamic, complex, and opening characteristics of land ecosystems, we constructed an evaluation indicator system for early-warning of LEH based on a perspective of state–danger–response. Then, we analyzed the warning condition of LEH in the Poyang lake eco-economic zone in China over the past decade using the variable weight matter-element model. The LEH status in the study region improved obviously from 2010 to 2020. The warning condition of regional LEH in 2010, 2015, and 2020 was in the “warning”, “relatively healthy”, and “healthy” stages, respectively. The evolution of LEH was better demonstrated by the variable weight matter-element model than by the traditional method because the former could modify the weight of early-warning indicators and eliminate the incompatibility between indicators. Our study provides an alternative approach for research into ecosystem health, and the results will be useful for improving LEH in the study region.
Mutational Profile Enables the Identification of a High Risk Subgroup in Myelodysplastic Syndromes With Isolated Trisomy 8
Authors: Toribio-Castelló Sofía , Castaño-Díez Sandra , Ramiro Angela Villaverde , Such Esperanza , Arnan Montserrat , Sole Francesc , Díaz-Beyá Marina , Díez-Campelo María , Rey Mónica del , González Teresa , Rivas Jesús María Hernández 
Published: February 2023

Abstract
Trisomy 8 (+ 8) is the most frequent trisomy in myelodysplastic syndromes (MDS) and is associated to clinical heterogeneity and intermediate cytogenetic risk when found isolated. The presence of gene mutations in this group of patients and the prognostic significance has not been extensively analyzed. Targeted-deep sequencing was performed in a cohort of 79 MDS patients showing isolated + 8. The most frequently mutated genes were: TET2 (38%), STAG2 (34.2%), SRSF2 (29.1%) and RUNX1 (26.6%). The mutational profile identified a high risk subgroup with mutations in STAG2, SRSF2 and/or RUNX1, resulting in shorter time to acute myeloid leukemia progression (14 months while not reached in patients without these mutations, p < 0.0001) and shorter overall survival (23.7 vs 46.3 months, p = 0.001). Multivariate analyses revealed the presence of mutations in these genes as an independent prognostic factor in MDS showing + 8isolated (HR: 3.1;p < 0.01). Moreover, 39.5% and 15.4% of patients classified as low/intermediate risk by the IPSS-R and IPSS-M respectively, were re-stratified as high risk subgroup based on the mutational status of STAG2, SRSF2 and RUNX1. Results were validated in an external cohort (n = 2 494). In summary, the mutational profile in isolated + 8 MDS patients could offer new insights for the correct management of these patients.
Relationship between triglyceride glucose index and severe abdominal aortic calcification in the elderly
Authors: Pan Dikang , Guo Julong , Su Zhixiang , Meng Wenzhuo , Wang Jingyu , Guo Jianming , Gu Yongquan 
Published: February 2023

Abstract
Background
The association between triglyceride glucose (TYG) index and depression is unclear. We conducted this analysis to explore whether higher TYG index is associated with a higher odd of depression.
Aims
The objective was to investigate the relationship between TYG and abdominal aortic calcification (AAC) in people over 60 years old.
Methods
The National Health and Nutrition Examination Survey data were analyzed using logistic regression models to examine the independent association between TYG index and the Kauppila AAC-24 score.
Results
A total of 1,408 people took part in our study. Participants with higher TYG quartiles had higher AAC scores. SAAC was defined as a Kauppila score > 6, and the prevalence of SAAC was 17.0%. After adjusting for relevant covariates, the multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CI) for participants in the third and fourth quartiles were 1.970 (1.232–3.150, P = 0.005) and 2.261 (1.404–3.644, P < 0.001). Subgroup analyses indicated that the positive association between TYG and SAAC persisted across population subgroups.
Conclusion
Triglyceride glucose index was negatively correlated with SAAC in the elderly.
Biomagnetic flow and radiative heat transfer along an inclined stretched cylinder with magnetic particles and heat source/sink under the influence of magnetic dipole
Authors: Ferdows M. , Alam Jahangir , Murtaza M. G. , Tzirtzilakis E. E. 
Published: February 2023

Abstract
The biomagnetic fluid (blood) flow with magnetic particles over an inclined stretched cylinder in the presence of a magnetic dipole is numerically studied. The effect of thermal radiation and heat source/sink are taken into consideration. For the mathematical formulation of the present problem both magnetization (polarization) and electrical conductivity of blood are taken into consideration. Consequently, the mathematical formulation of Biomagnetic Fluid Dynamics (BFD) is utilized, where both principles of magnetohydrodynamics (MHD) and ferrohydrodynamics (FHD) are taken into account. The governing non-linear partial differential equations are transformed into ordinary differential equations by using a similarity approach. The numerical solution is obtained by employing the bvp4c function in MATLAB R2018b software. The results are presented graphically and discussed for various parameters that are involved in this problem. Considering the electrical conductivity and magnetization of blood with magnetic particles, the effect of magnetohydrodynamic interaction parameter and ferrohydrodynamic interaction parameter on velocity and temperature profiles are discussed. One of the major findings is that the rate of heat transfer and skin friction coefficient are increased and decreased, respectively with increasing values of the volume fraction. It is obtained that the effect of the magnetic field is significantly enchased by the presence of the magnetic particles to blood.
Metformin has a protective effect against oxidative stress in patients with diabetes mellitus type 2
Authors: Manica Daiane , Sandri Gabriela , Silva Gilnei Bruno , Manica Aline , Bonadiman Beatriz da Silva Rosa , Santos Daniel , Flores Érico Marlon Moraes , Bolzan Rodrigo Cordeiro , Barcelos Raquel Cristine Silva , Tomazoni Fernanda , Suthovski Gabriela , Bagatini Margarete Dulce , Benvegnú Dalila Moter 
Published: February 2023

Abstract
Diabetes mellitus (DM) and arterial hypertension are considered serious public health problems. Several studies have shown that oxidative stress is usually related to the onset of DM and hypertension and their complications. Moreover, levels of some minerals are closely related to the pathophysiology of these diseases. Thus, the present study aimed to evaluate the biochemical markers, minerals and redox profile levels in the serum of patients with type 2 DM and hypertension, as well as to test the effect of metformin on the viability and redox profile of cells. Patients with type 2 DM and hypertension + type 2 DM had higher levels of fasting glucose and triglycerides. There were no statistically significant differences for mineral levels. The MPO activity was reduced in the DM type 2 and Hypertension + DM type 2 groups and in cells. On the other hand, PSH and vitamin C levels were increased. The metformin has a protective effect in patients with DM type 2 against oxidative stress by reducing MPO activity and improving PSH and vitamin C antioxidant defenders. Further studies are needed to assess the biochemical mechanisms of metformin and how it can be used in a pharmacological therapeutic perspective against oxidative damage.
An Experimental Study of the pVTx Propertiesfor Aqueous Solutions of Ammonia
Authors: Oguchi Kosei 
Published: February 2023

Abstract
In order to know the hydrogen bonding effects on H2O+NH3 mixtures, the pVTx properties of H2O+NH3 mixtures were measured and reported some of them [1]. As the result, the phenomena of hydrogen bonding effects in H2O+NH3 mixtures were revealed for the first time. However, there were several misprinted data where the mixture composition and the pVT data were misaligned. Therefore, the correct experimental data were shown in Table 1. In these data, the hydrogen bonding behavior appeared in the measured values of 0.0 to 0.0644 mole fraction. And also, in order to confirm whether macroscopic phenomena due to hydrogen bonding appears in other compositions, pVTx properties of this substance were measured in the mixtures of both 0.4810-0.5357 mol fraction and 0.9592-0.9638 mol fraction.