bluuebunny/crossref_metadata_2025_split huggingface dataset:
In‐Plane Anisotropy in van der Waals NiTeSe Ternary Alloy
Authors: Lam Nguyen Huu , Rhee Tae Gyu , Kim Seongmun , Choi Byoung Ki , Hoang Dang Nguyen , Duvjir Ganbat , Hwang Younghun , Lee Jaekwang , Chang Young Jun , Kim Jungdae 
Published: January 2025

AbstractThe anisotropic properties of materials profoundly influence their electronic, magnetic, optical, and mechanical behaviors and are critical for a wide range of applications. In this study, the anisotropic characteristics of Ni‐based van der Waals materials, specifically NiTe2 and its alloy NiTeSe, utilizing a combination of comprehensive scanning tunneling microscopy (STM), angle‐resolved photoemission spectroscopy (ARPES), and density functional theory (DFT) calculations, are explored. Unlike 1T‐NiTe2, which exhibits trigonal in‐plane symmetry, the substitution of Te with Se in NiTe2 (resulting in the NiTeSe alloy) induces a pronounced in‐plane anisotropy. This anisotropy is clear in the STM topographs, which reveal a distinct linear order of charge distribution. Corroborating these observations, ARPES measurements and DFT calculations reveal an anisotropic Fermi surface centered at the point, which is notably elongated along the ky direction, leading to directional variations in in‐plane carrier velocities. Consequently, the Fermi velocity is highest along the kx direction where the linear charge distribution aligns in real space and is lowest along the ky direction. These findings offer valuable insights into the tunability of anisotropic properties in ternary transition metal dichalcogenide systems, highlighting their potential applications in the development of anisotropic electronic and optoelectronic devices.
Multi‐miRNAs‐Mediated Hepatic Lepr Axis Suppression: A Pparg–Dicer1 Pathway‐Driven Mechanism in Spermatogenesis for the Intergenerational Transmission of Paternal Metabolic Syndrome
Authors: Lin Yi , Ni Xiuye , Zhu Lin , Lin Yilong , Peng Cai , Lei Zhao , Wang Yihui , Wang Huan , You Xiang , Li Juan , Shen Heqing , Wei Jie 
Published: January 2025

AbstractBisphenol A (BPA) is an “environmental obesogen” and this study aims to investigate the intergenerational impacts of BPA‐induced metabolic syndrome (MetS), specifically focusing on unraveling mechanisms. Exposure to BPA induces metabolic disorders in the paternal mice, which are then transmitted to offspring, leading to late‐onset MetS. Mechanistically, BPA upregulates Srebf1, which in turn promotes the Pparg‐dependent transcription of Dicer1 in spermatocytes, increasing the levels of multiple sperm microRNAs (miRNAs). Several of these miRNAs are highly expressed in a synchronized manner in liver of the offspring. miR149‐5p, miR150‐5p, and miR700‐5p target a specific region in the Lepr 3′UTR, termed “SMITE” (“Several MiRNAs Targeting Elements”), to negatively regulate Lepr. These inherited anti‐Lepr miRNAs, also referred to inherited anti‐Lepr miRNAs (IAL‐miRs), modulate hepatic steatosis, and insulin signaling through the Lepr regulatory Igfbp2, Egfr, and Ampk. Furthermore, IAL‐miRs inhibit Ccnd1 not only via binding to “SMITE” but also via Lepr–Igfbp2 axis, which contribute to hepatocyte senescence. These pathological processes interact in a self‐reinforcing cycle, worsening MetS in the paternal BPA‐exposed offspring. The findings reveal mechanism wherein lipid metabolism reprogramming in spermatocytes‐induced perturbations of sperm miRNAs, triggered by BPA, leads to intergenerational inheritance of paternal MetS through suppression of the hepatic Lepr axis in the offspring.
Catalytic Hydrolysis of Perfluorinated Compounds in a Yolk–Shell Micro‐Reactor
Authors: Zheng Jialin , Wang Xiaojian , Zi Xin , Zhang Hang , Chen Heping , Pensa Evangelina , Liu Kang , Fu Junwei , Lin Zhang , Chai Liyuan , Cortés Emiliano , Liu Min 
Published: January 2025

AbstractPerfluorinated compounds (PFCs) are emerging environmental pollutants characterized by their extreme stability and resistance to degradation. Among them, tetrafluoromethane (CF4) is the simplest and most abundant PFC in the atmosphere. However, the highest C─F bond energy and its highly symmetrical structure make it particularly challenging to decompose. In this work, a yolk–shell Al2O3 micro‐reactor is developed to enhance the catalytic hydrolysis performance of CF4 by creating a local autothermic environment. Finite element simulations predict that the yolk–shell Al2O3 micro‐reactor captures the heat released during the catalytic hydrolysis of CF4, resulting in a local autothermic environment within the yolk–shell structure that is 50 °C higher than the set temperature. The effectiveness of this local autothermic environment is experimentally confirmed by in situ Raman spectroscopy. As a result, the obtained yolk–shell Al2O3 micro‐reactor achieves 100% CF4 conversion at a considerably low temperature of 580 °C for over 150 h, while hollow and solid Al2O3 structures required higher temperatures of 610 and 630 °C, respectively, to achieve the same conversion rate, demonstrating the potential of yolk–shell Al2O3 micro‐reactor to significantly reduce the energy requirements for PFCs degradation and contribute to more sustainable and effective environmental remediation strategies.
A Transient Photoelectric Spiking Neuron Based on a Highly Robust MgO Composite Threshold Switching Memristor for Selective UV Perception
Authors: Cao Yaxiong , Wang Rui , Wang Saisai , Zeng Tonglong , Zhang Wanlin , Sun Jing , Ma Xiaohua , Wang Hong , Hao Yue 
Published: January 2025

AbstractThe biological photoreceptors in the retina convert light information into spikes, inspiring the emergence of artificial photoelectric spiking neurons. However, due to the lack of biocompatible and biodegradable characteristics, artificial photoelectric spiking neurons based on threshold switching (TS) devices are not available for bio‐integrated optical medical diagnostics and neuromorphic computing. Here, an artificial photoelectric spiking neuron integrated with a physically transient memristor and photodetector for UV perception is proposed. The transient memristor with a MgO:Mg resistive layer implemented by the co‐sputtering process of MgO and Mg targets shows highly robust TS performance, while the ZnO‐based transient photodetector can selectively detect UV light at power densities below 10 mW cm−2. More interestingly, the frequency of the firing spikes generated by artificial photoelectric spiking neuron increases with the enhancement of UV light intensity. In addition, the recognition accuracy of UV information extracted from the surrounding environment reaches ≈99.8% by spiking neural network consisting of photoelectric spiking neuron when the object that blended into the background are not easily detected. This work demonstrates that the functions of the biological photoreceptors may be truly mimicked by artificial photoelectric spiking neuron with transiency, expanding its application in optical disease diagnosis and implantable visual neuromorphic computing.
Impact of Baseline Thrombocytopenia on Early Outcomes in Patients With Acute Venous Thromboembolism
Authors: Lecumberri Ramón , Ruiz‐Artacho Pedro , Trujillo‐Santos Javier , Marcos‐Jubilar María , Pérez‐Pinar Montserrat , Quéré Isabelle , Claver Gisela , Gorostidi Juan , Bikdeli Behnood , Monreal Manuel ,   The RIETE Investigators
Published: January 2025

ABSTRACTManaging acute venous thromboembolism (VTE) in patients with thrombocytopenia is challenging. We used data from the RIETE registry to investigate the impact of baseline thrombocytopenia on early VTE‐related outcomes, depending on the initial presentation as pulmonary embolism (PE) or isolated lower‐limb deep vein thrombosis (DVT). From March 2003 to November 2022, 90 418 patients with VTE were included. Thrombocytopenia was categorized as severe (< 50 000/μL, n = 303) or moderate (50 000–99 999/μL, n = 1882). The primary outcome, fatal PE within 15 days after diagnosis, and secondary outcomes, including major bleeding and recurrent VTE, were analyzed using multivariable‐adjusted models. Among 52 703 patients with PE, the 15‐day case‐fatality rates from PE were 5.8% for severe thrombocytopenia, 4.5% for moderate thrombocytopenia, and 1.1% for normal platelet counts. In 37 715 patients with isolated DVT, the cumulative incidence of fatal PE were 0, 0.2%, and 0.05%, respectively. Multivariable analysis revealed a five‐fold increase in the risk for fatal PE in severe thrombocytopenia (adjusted HR: 4.89; 95%CI: 2.55–9.39) without significant differences between severe and moderate thrombocytopenia. Thrombocytopenia, either moderate or severe, was also associated with increased risk for both, major bleeding and recurrent VTE at 15 days. Initial presentation with PE substantially worsened prognosis compared to isolated DVT. In conclusion, in patients with acute VTE, thrombocytopenia at baseline was associated with increased risk of early death from PE, a finding that was driven by the subgroup whose initial presentation was PE.
Insights From Minnesota on Newborn Screening for Adrenoleukodystrophy: A 5‐Year Update
Authors: Rayannavar Arpana , Billington Charles J. , Tryon Rebecca , Kaye Tory , Gupta Ashish , Lund Troy C. , Lteif Aida , Adriatico Katherine , Orchard Paul J. , Miller Bradley S. , Pillai Nishitha R. 
Published: January 2025

ABSTRACTOur objectives are to report on the outcomes of adrenal insufficiency (AI) and cerebral ALD (cALD) in children diagnosed with X‐linked adrenoleukodystrophy (ALD) identified by newborn screening (NBS) in Minnesota in the first 5 years following initiation of NBS in 02/2017. A retrospective chart review was conducted for children diagnosed with ALD via Minnesota NBS from 02/06/2017 through 02/06/2022. Data reviewed included newborn screening data, diagnostic very long chain fatty acid levels, ABCD1 molecular testing results, serial measurements of ACTH and cortisol, and serial brain MRI results. Thirty‐two boys and 11 girls were molecularly and/or biochemically confirmed to have ALD. Of these 32 boys, six (2–7 years; median age:18 months) developed AI. Two boys developed cALD and underwent stem cell transplantation, one of whom also has been diagnosed with AI. All the pathogenic/likely pathogenic variants detected during the first 5 years had initial C26:0 lysophosphatidylcholine (C26:0 lysoPC) values over 0.3 μmol/L at the time of newborn screening. The addition of ALD to NBS in Minnesota has allowed for early detection of asymptomatic AI in six young patients and asymptomatic cALD in two patients. Data from our study shows a positive correlation between high newborn screening LysoPC levels and variant pathogenicity.
Improving Photocatalytic Hydrogen Generation via Polycitric Acid‐based Carbon Nanodots
Authors: Langford Daniel , Reva Yana , Bo Yifan , Gubanov Kirill , Wu Mingjian , Günay‐Gürer Ayşe , Mai Lukas A. , Crisp Ryan W. , Engelmann Iryna , Spiecker Erdmann , Fink Rainer H. , Kahnt Axel , Jana Bikash , Guldi Dirk M. 
Published: January 2025

AbstractBottom‐up syntheses of carbon nanodots (CND) using solvothermal treatment of citric acid are known to afford nanometer‐sized, amorphous polycitric acid‐based materials. The addition of suitable co‐reactants in the form of in situ synthesized N‐hetero‐π‐conjugated chromophores facilitates hereby the overall functionalization. Reports regarding the influence of CND on the properties of, for example, N‐hetero‐π‐conjugated chromophores are scarce. Thus, our incentive was to design a CND model that features phenazine (P‐CND) – a well‐known N‐hetero‐π‐conjugated chromophore – to investigate the influence of the CND matrix on its redox chemistry as well as photochemistry. The scope of our work was to go beyond investigating the electrochemical properties of the resulting P‐CND by shedding light onto differences relative to nano‐aggregates of phenazine (PNZNA), which served as reference. In particular, chemical as well as electrochemical reduction of PNZNA initiated a reaction cascade that affords the primary reduction intermediate, that is, the reduced and protonated (PNZ‐H)⋅. In accordance with existing literature, the final product of a bimolecular disproportionation was 5,10‐dihydrophenazine (PNZ‐H2). Reducing P‐CND also resulted in the formation of (PNZ‐H)⋅. But, no evidence for a subsequent bimolecular disproportionation was gathered. Instead, (PNZ‐H)⋅ as an integrative part of P‐CND was found to be actively involved in a H2 generation reaction. A more than twofold increase in efficiency compared to PNZNA under identical conditions was the consequence.
Ring‐in‐Ring Assembly Facilitates the Synthesis of a [12]Cycloparaphenylene ABC‐Type [3]Catenane
Authors: Shi Wudi , Hu Yaning , Leanza Luigi , Shchukin Yevhenii , Hoffmann Patrick A. , Li Meng‐Hua , Ning Chengbing , Cao Zhong‐Yan , Xu Yuan‐Qing , Du Pingwu , von Delius Max , Pavan Giovanni M. , Xu Youzhi 
Published: January 2025

AbstractCycloparaphenylenes (CPPs) represent a significant challenge for the synthesis of mechanically interlocked architectures, because they lack heteroatoms, which precludes traditional active and passive template methods. To circumvent this problem and explore the fundamental and functional properties of CPP rotaxanes and catenanes, researchers have resorted to unusual non‐covalent and even to labor‐intensive covalent template approaches. Herein, we report a ring‐in‐ring non‐covalent template strategy that makes use of the surprisingly strong non‐covalent inclusion of crown ethers into suitably sized CPPs. By threading a secondary ammonium salt through the crown ether and closing the third ring via CuAAC click reaction, we obtained a rare ABC‐type hetero‐[3]catenane comprising [12]CPP, 24‐crown‐8 and a dibenzylammonium macrocycle. X‐ray crystallography shed light on the ring‐in‐ring pre‐organization and the [3]catenane topology was confirmed by NMR and MS‐MS studies. Molecular simulations provided insights into the intriguing ring‐vs.‐ring‐vs.‐ring dynamics of the [3]catenane, which are highly dependent on the protonation state of the dibenzylammonium site. This ring‐in‐ring assembly strategy opens new avenues for the synthesis of complex CPP architectures and their use in functional supramolecular systems.
Formamidine as an Easy‐On and Easy‐Off Linker for Reversible Crosslinking of Two Alkyl Amines in Peptide Stapling and Conjugation
Authors: Chu Xin , Zhang Zhang , Xu Xiaoxi , Guan Wenli , Jiang Shuai , Cai Shaokun , Yang Tianxi , He Gang , Zhou Chuanzheng , Chen Gong 
Published: January 2025

AbstractAmino groups are abundant in both natural and synthetic molecules, offering highly accessible sites for modifying native biorelevant molecules. Despite significant progress with more reactive thiol groups, methods for ligating two amino groups with reversible linkers for bioconjugation applications remain elusive. Herein, we report the use of oxidative decarboxylative condensation of glyoxylic acid to crosslink or ligate two alkyl amines via a compact formamidine linkage, applicable in both intra‐ and intermolecular contexts. This linking chemistry exhibits unique hetero‐coupling selectivity between primary and secondary alkyl amines. Although the formamidine linkage is stable under pH‐neutral buffers and acidic conditions, it can be readily cleaved with ethylenediamine or hydrazine under mild conditions in alcohol solvents or aqueous media, fully restoring the amino groups. This study introduces a rare ‘easy‐on and easy‐off’ strategy for connecting two native amines in peptide stapling and biomolecule conjugation.
Interfacial Oxygen Vacancy‐Copper Pair Sites on Inverse CeO2/Cu Catalyst Enable Efficient CO2 Electroreduction to Ethanol in Acid
Authors: Qiao Yan , Shen Shenyu , Mao Chenghui , Xiao Yongchun , Lai Wenchuan , Wang Yanan , Zhong Xingyu , Lu Yangfan , Li Jiong , Ge Jingjie , Hsu Hsien‐Yi , Su Yaqiong , Shao Minhua , Hu Zheng , Huang Hongwen 
Published: January 2025

AbstractRenewable electricity‐driven electrochemical reduction of CO2 offers a promising route for the production of high‐value ethanol. However, the current state of this technology is hindered by low selectivity and productivity, primarily due to a limited understanding of the atomic‐level active sites involved in ethanol formation. Herein, we identify that the interfacial oxygen vacancy‐neighboring Cu (Ov‐Cu) pair sites are the active sites for CO2 electroreduction to ethanol. A linear correlation between the density of Ov‐Cu pair sites and ethanol productivity is experimentally evidenced. Moreover, a high Faradaic efficiency of 48.5 % and a partial current density of 344.0 mA cm−2 for ethanol production are achieved over the inverse CeO2/Cu catalyst with a high density of Ov‐Cu pair sites in acid. Mechanistic studies that combine density functional theory calculations and spectroscopic techniques propose an Ov‐involved mechanism where interfacial Ov sites directly activate and dissociate CO2 into *CO in a thermodynamically spontaneous manner, thus favoring the subsequent *CHO formation and asymmetric CHO‐CO coupling. Besides, the asymmetric Ov‐Cu pair sites could preferentially stabilize the *CH2CHOH intermediate, resulting in the favorable formation of ethanol over ethylene. Our findings provide new atomic‐level insights into CO2 electroreduction to ethanol, paving the way for the rational design of future catalysts.
Selbstassemblierung von Amorphen 2D‐Polymer‐Nanoscheiben mit Einstellbarer Größe, pH‐Abhängigem Abbau und Kontrollierter Wirkstofffreisetzung
Authors: Zeng Haoxiang , Zeng Ping , Baek Jinsu , Kim Byeong‐Su , Müllner Markus 
Published: January 2025

AbstractAmphiphile Flaschenbürsten‐Blockcopolymere (BBCs) mit kaulquappenähnlicher Knäuel‐ Stäbchen ‐Architektur können zur direkten Selbstassemblierung zu funktionellen Polymer‐Nanoscheiben in Wasser verwendet werden. Die hydrophoben Segmente der BBCs wurden durch das Verhältnis von Ethoxy‐ethylglycidylether (EE) zu Tetrahydropyranylglycidylether (TP) innerhalb der gepfropften Polymerseitenketten eingestellt. Diese Variation steuerte wiederum die Größen, pH‐Empfindlichkeit und Wirkstoffbeladungskapazität der selbstorganisierten Nanoscheiben. Bemerkenswert ist, dass EE eine schnellere Hydrolyse als TP aufwies, wodurch die Nanoscheiben variable Abbauraten unter mild sauren Bedingungen zeigten, was die Freisetzung kleiner Moleküle und den zeitabhängigen und vollständigen Abbau der Scheiben zu vollständig wasserlöslichen Copolymeren unterstützte. Die Nanoscheiben zeigten Biokompatibilität und zelluläre Aufnahme durch Brustkrebszellen, was ihr Potenzial zur Entwicklung von Wirkstofffreisetzungssystemen unterstreicht.
Anion Transport by Bambusuril‐Bile Acid Conjugates: Drastic Effect of the Cholesterol Content
Authors: Torrisi Jacopo , Chvojka Matúš , Jurček Pia , Zhang Xinxin , Zeng Huaqiang , Šindelář Vladimír , Valkenier Hennie 
Published: January 2025

AbstractArtificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self‐assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well‐established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.
Enzymatic Cascades for Stereoselective and Regioselective Amide Bond Assembly
Authors: Torri Daniele , Bering Luis , Yates Luke R. L. , Angiolini Stuart M. , Xu Guangcai , Cuesta‐Hoyos Sebastian , Shepherd Sarah A. , Micklefield Jason 
Published: January 2025

AbstractAmide bond formation is fundamental in nature and is widely used in the synthesis of pharmaceuticals and other valuable products. Current methods for amide synthesis are often step and atom inefficient, requiring the use of protecting groups, deleterious reagents and organic solvents that create significant waste. The development of cleaner and more efficient catalytic methods for amide synthesis remains an urgent unmet need. Herein, we present novel biocatalytic cascade reactions for synthesising various amides under mild aqueous conditions from readily available organic nitriles combining nitrile hydrolysing enzymes and amide bond synthetase enzymes. These cooperative biocatalytic cascades enable kinetic resolution of racemic nitriles and provide a highly enantioselective biocatalytic extension of the Strecker reaction. The regioselective non‐directed C−H bond amidation of simple arenes was demonstrated through the incorporation of photoredox catalysis to the front end of the cascade. C−H bond amidation of simple aromatic precursors was also achieved via a CO2 fixation cascade combining enzymatic carboxylation and amide bond synthesis in one‐pot.
A Malleable Collagen‐Mimic that Undergoes Moisture‐Induced Hardening for Gluing Hydrophilic Surfaces
Authors: Rai Rishika , Xavier Divina , Pathak Sourav , Fernandez Francis B. , Komath Manoj , Sureshan Kana M. 
Published: January 2025

AbstractA collagen‐inspired helical protein‐mimic has been synthesized via topochemical polymerization of a designed tripeptide monomer. In the monomer crystal, molecules arrange in a head‐to‐tail manner, forming supramolecular helices. The azide and alkyne of adjacent molecules in the supramolecular helix are proximally preorganized in a ready‐to‐react arrangement. On heating, the monomer crystals undergo regiospecific single‐crystal‐to‐single‐crystal azide‐alkyne cycloaddition polymerization, yielding triazolyl‐ polypeptide. Polymerization softens the crystals, making the polymer malleable and mouldable. The polymer grains absorb moisture and form agglomerates through water‐bridged adhesion, which hardens over time. The weight‐bearing capacity of a mould made from this polymer increased by 50‐fold due to moisture‐induced hardening. We have demonstrated that this collagen‐mimic can glue both biological specimens such as wood and bone and synthetic materials such as glass and paper. In vitro studies established the biocompatibility, making it an attractive bioinspired material for potential application as a bioadhesive.
Self‐Assembly of Amorphous 2D Polymer Nanodiscs with Tuneable Size, pH‐Responsive Degradation and Controlled Drug Release
Authors: Zeng Haoxiang , Zeng Ping , Baek Jinsu , Kim Byeong‐Su , Müllner Markus 
Published: January 2025

AbstractAmphiphilic bottlebrush block copolymers (BBCs) with tadpole‐like, coil‐rod architecture can be used to self‐assemble into functional polymer nanodiscs directly in water. The hydrophobic segments of the BBC were tuned via the ratio of ethoxy‐ethyl glycidyl ether (EE) to tetrahydropyranyl glycidyl ether (TP) within the grafted polymer sidechains. In turn, this variation controlled the sizes, pH‐responsiveness, and drug loading capacity of the self‐assembled nanodiscs. Notably, as EE exhibited faster hydrolysis than TP, the nanodiscs featured variable degradation rates under mild acidic conditions, aiding small molecule release and time‐dependent and complete degradation of discs into fully water‐soluble copolymers. The nanodiscs demonstrated biocompatibility and cellular uptake by breast cancer cells, underscoring their potential development into drug delivery systems.