bluuebunny/crossref_metadata_2025_split huggingface dataset:
Older patients with primary central nervous system lymphoma: Survival and prognostication across 20 U.S. cancer centers
Authors: David Kevin A. , Sundaram Suchitra , Kim Seo‐Hyun , Vaca Ryan , Lin Yong , Singer Samuel , Malecek Mary‐Kate , Carter Jordan , Zayac Adam , Kim Myung Sun , Reddy Nishitha , Ney Douglas , Habib Alma , Strouse Christopher , Graber Jerome , Bachanova Veronika , Salman Sidra , Vendiola Jean Alyxa , Hossain Nasheed , Tsang Mazie , Major Ajay , Bond David A. , Agrawal Prashasti , Mier‐Hicks Angel , Torka Pallawi , Rajakumar Priya , Venugopal Parameswaran , Berg Stephanie , Glantz Michael , Goldlust Samuel A. , Folstad Matthew , Kumar Pallavi , Ollila Thomas A. , Cai Johnny , Spurgeon Stephen , Sieg Alex , Cleveland Joseph , Chang Julie , Epperla Narendranath , Karmali Reem , Naik Seema , Martin Peter , Smith Sonali M. , Rubenstein James , Kahl Brad , Evens Andrew M. 
Published: March 2023

AbstractThere is a paucity of large‐scale data delineating outcomes and prognostication of older patients with primary central nervous system lymphoma (PCNSL). We retrospectively analyzed 539 newly‐diagnosed PCNSL patients ages ≥60 years across 20 U.S. academic centers. The median age was 70 years (range 60–88); at least one geriatric syndrome was present in 46%; the median Cumulative Index Ratings Scale‐Geriatrics (CIRS‐G) score was 6 (range, 0–27); and 36% had impairment in activities of daily living (ADL). The most common induction regimens were high‐dose methotrexate (HD‐MTX) ± rituximab; methotrexate, temozolomide, rituximab (MTR); and rituximab, methotrexate, procarbazine, vincristine (R‐MPV). Overall, 70% of patients achieved remission, with 14% undergoing consolidative autologous stem cell transplant (ASCT) and 24% receiving maintenance. With 58‐month median follow‐up, median progression‐free survival (PFS) and overall survival (OS) were 17 months (95% CI 13–22 months) and 43 months (95% CI 31–56 months), respectively. Three‐year PFS and OS were highest with MTR (55% and 74%, respectively). With single‐agent methotrexate ± rituximab, 3‐year PFS and OS were 30% (p = .0002) and 47% (p = .0072). On multivariate analysis, increasing age at diagnosis and Cooperative Oncology Group (ECOG) performance status (PS) was associated with inferior PFS; age, hypoalbuminemia, higher CIRS‐G score, and ECOG PS adversely affected OS. Among patients receiving maintenance, 3‐year PFS was 65% versus 45% without maintenance (p = 0.02), with 3‐year OS of 84% versus 61%, respectively (p = .0003). Altogether, outcomes in older PCNSL patients appeared optimized with HD‐MTX combination induction regimens and maintenance therapy. Furthermore, several prognostic factors, including geriatric measures, were associated with inferior outcomes.
A novel RYR1 variant in an infant with a unique fetal presentation of central core disease
Authors: Baker Elizabeth K. , Al Gharaibeh Faris N. , Bove Kevin , Calvo‐Garcia Maria A. , Shillington Amelle , VandenHeuvel Katherine , Cortezzo DonnaMaria E. 
Published: March 2023

AbstractRyanodine receptor type 1‐related disorder (RYR1‐RD) is the most common subgroup of congenital myopathies with a wide phenotypic spectrum ranging from mild hypotonia to lethal fetal akinesia. Genetic testing for myopathies is imperative as the diagnosis informs counseling regarding prognosis and recurrence risk, treatment options, monitoring, and clinical management. However, diagnostic challenges exist as current options are limited to clinical suspicion prompting testing including: single gene sequencing or familial variant testing, multi‐gene panels, exome, genome sequencing, and invasive testing including muscle biopsy. The timing of diagnosis is of great importance due to the association of RYR1‐RD with malignant hyperthermia (MH). MH is a hypermetabolic crisis that occurs secondary to excessive calcium release in muscles, leading to systemic effects that can progress to shock and death if unrecognized. Given the association of MH with pathogenic variants in RYR1, a diagnosis of RYR1‐RD necessitates an awareness of medical team to avoid potentially triggering agents. We describe a case of a unique fetal presentation with bilateral diaphragmatic eventrations who had respiratory failure, dysmorphic facial features, and profound global hypotonia in the neonatal period. The diagnosis was made at several months of age, had direct implications on her clinical care related to anticipated need to long‐term ventilator support, and ultimately death secondary an arrhythmia as a result of suspected MH. Our report reinforces the importance of having high suspicion for a genetic syndrome and pursuing early, rapid exome or genome sequencing as first line testing in critically ill neonatal intensive care unit patients and further evaluating the pathogenicity of a variant of uncertain significance in the setting of a myopathic phenotype.
Clinical exome sequencing findings in 1589 patients
Authors: Gorukmez Ozlem , Gorukmez Orhan , Topak Ali 
Published: March 2023

AbstractClinical exome sequencing (CES) is important for the diagnosis of Mendelian diseases, which are clinically and etiologically heterogeneous. Sharing of large amounts of CES data associated with clinical findings will increase the accuracy of variant interpretation. We performed a retrospective study to state the diagnostic yield of CES in 1589 patients with a wide phenotypic spectrum. CES was performed using the Sophia Clinical Exome Sequencing Kit with 4493 genes, followed by sequencing on a NextSeq 500 system. The diagnosis rate was 36.8% when only pathogenic and likely pathogenic variants were included. Consanguineous unions and positive family history were associated with a high diagnostic yield. The neurological disease group had the highest number of patients. The groups with high diagnosis rates were ear, eye, and muscle disease groups. Seven candidate genes (EFHC2, HSPB3, FAAH2, ITGB1, GYG2, CD177, and CSTF2T) that are not yet associated with human diseases were identified. Owing to the high diagnostic yield of CES compared with that of other genetic tests, it can be used as a standard diagnostic test in patients with rare genetic disorders that require a wide differential diagnosis, especially in laboratories with limited resources.
Measuring the Quantum State of Dark Matter
Authors: Marsh David J. E. 
Published: March 2023

AbstractIt is shown how the time series obtained from searches for ultralight bosonic dark matter (DM), such as the axion, can be used to determine whether it is in a coherent or incoherent quantum state. The example is essentially trivial, but it is hoped that explicitly addressing it will provoke experimental exploration. In the standard coherent state, oscillations in the number density occur over the coherence time, , where m is the particle mass and v is the galactic virial velocity, leading to a reduction in the constraining power of experiments operating on timescales , due to the unknown global phase. On the other hand, if the DM is incoherent then no such strong number oscillations occur since the ensemble average over particles in different streams gives an effective phase average. If an experiment detects a signal then the coherent or incoherent nature of DM can be determined by time series analysis over the coherence time. This finding is observationally relevant for DM masses, (corresponding to coherence times between a year and 100 s).
Bimetallic Cooperativity and Hydrogen Bonding Allow Efficient Reduction of CO2
Authors: Dey Abhishek 
Published: March 2023

AbstractReducing CO2 selectively to one of the several C1 products is challenging, as the thermodynamic reduction potentials for the different n e−/n H+ reductions of CO2 are similar and so is the reduction potential for H+ reduction. Recently, Halime, Aukauloo, and co‐workers have taken inspiration from the active site of nickel CO dehydrogenase (Ni‐CODH) to design bimetallic iron porphyrins bridged by a urea moiety. These complexes show fast and selective reduction of CO2 to CO and the results suggest a Ni‐CODH type mechanism at play where one of the two metals binds and reduces the CO2 while the other stabilizes the reduced species by forming a bridged complex, facilitating the C−O bond cleavage.
Efficient Near‐Infrared Electroluminescence from Lanthanide‐Doped Perovskite Quantum Cutters
Authors: Yu Yan‐Jun , Zou Chen , Shen Wan‐Shan , Zheng Xiaopeng , Tian Qi‐Sheng , Yu You‐Jun , Chen Chun‐Hao , Zhao Baodan , Wang Zhao‐Kui , Di Dawei , Bakr Osman M. , Liao Liang‐Sheng 
Published: March 2023

AbstractPerovskite nanocrystals (PeNCs) deliver size‐ and composition‐tunable luminescence of high efficiency and color purity in the visible range. However, attaining efficient electroluminescence (EL) in the near‐infrared (NIR) region from PeNCs is challenging, limiting their potential applications. Here we demonstrate a highly efficient NIR light‐emitting diode (LED) by doping ytterbium ions into a PeNCs host (Yb3+ : PeNCs), extending the EL wavelengths toward 1000 nm, which is achieved through a direct sensitization of Yb3+ ions by the PeNC host. Efficient quantum‐cutting processes enable high photoluminescence quantum yields (PLQYs) of up to 126 % from the Yb3+ : PeNCs. Through halide‐composition engineering and surface passivation to improve both PLQY and charge‐transport balance, we demonstrate an efficient NIR LED with a peak external quantum efficiency of 7.7 % at a central wavelength of 990 nm, representing the most efficient perovskite‐based LEDs with emission wavelengths beyond 850 nm.
A BN‐Doped U‐Shaped Heteroacene as a Molecular Floating Gate for Ambipolar Charge Trapping Memory
Authors: Yu Yang , Wang Le , Lin Dongqing , Rana Shammi , Mali Kunal S. , Ling Haifeng , Xie Linghai , De Feyter Steven , Liu Junzhi 
Published: March 2023

AbstractTwo wide‐band gap U‐shaped polycyclic aromatic hydrocarbons with/without boron and nitrogen (BN‐) doping (BN‐1 and C‐1) were synthesized to tune the electronic features to suit the performance requirements for organic field‐effect transistor memory (OFET‐NVM). The chemical structures were characterized by scanning tunneling microscopy and single‐crystal diffraction. Owing to the electron‐donor effect of N and the high electron affinity of B, the BN‐1‐based OFET‐NVM displays large ambipolar memory windows and an enhanced charge storage density compared to C‐1 and most reported small molecules. A novel supramolecular system formed from BN‐1 and PMMA contributes to fabricating uniform films with homogeneous microstructures, which serve as a two‐in‐one tunnelling dielectric and charge‐trapping layer to realize long‐term charge retention and reliable endurance. Our results demonstrate that both BN doping and supramolecular engineering are crucial for the charge trapping of OFET‐NVM.
Nickel‐promoted Electrocatalytic Graphitization of Biochars for Energy Storage: Mechanistic Understanding using Multi‐scale Approaches
Authors: Li Shijie , Han Xue , Song Wei‐Li , Wang Zhe , Zhu Yan‐li , Jiao Shuqiang 
Published: March 2023

AbstractOwing to high‐efficiency and scalable advantages of electrolysis in molten salts, electrochemical conversion of carbonaceous resources into graphitic products is a sustainable route for achieving high value‐added carbon. To understand the complicated kinetics of converting amorphous carbon (e.g. carbonized lignin‐biochar) into highly graphitic carbon, herein this study reports the key processing parameters (addition of Ni, temperature and time) and multi‐scale approach of nickel‐boosted electrochemical graphitization‐catalysis processes in molten calcium chloride. Upon both experiments and modellings, multi‐scale analysis that ranges from nanoscale atomic reaction to macroscale cell reveal the multi‐field evolution in the electrolysis cell, mechanism of electrochemical reaction kinetics as well as pathway of nickel‐boosted graphitization and tubulization. The results of as‐achieved controllable processing regions and multi‐scale approaches provide a rational strategy of manipulating electrochemical graphitization processes and utilizing the converted biomass resources for high value‐added use.
Single fiber coating of viscose filaments with cellulose acetate for partially hydrophobic hybrid fibers
Authors: Wurm Florian , Netzer Felix , Schäffner Uwe , Leukel Jörg , Schweiß Julia , Pham Tung , Bechtold Thomas 
Published: March 2023

AbstractThe focus of this work was to investigate the cellulose acetate (CA)–viscose (CV) interface in an all‐cellulosic compound and to evaluate the feasibility of hydrophobic CA‐coatings on viscose fibers. Mechanical strengths of cellulose foil‐CA compounds were investigated by recoding stress‐to‐strain curves. For equivalent strain, composites generate higher stress than pure CA samples. For the CA coating on CV fibers, fibers were pretreated in 2.5% by mass sodium hydroxide solution and drawn through a solution of 2%, 4%, 6%, 8%, and 10% by mass in acetone dissolved CA. Properties of coated fibers were investigated with LSM microscopy, ATR‐FTIR, DVS, and by determining the fiber titer and tenacity. A decrease in fiber tenacity and vapor sorption is associated with a change of the fiber titer due to the increasing shares of CA. Therefore, the hypothesis of a hydrophobically coated CV fiber, via the described process, is mostly rejected, although double‐coatings with CA seem to reduce condensation of water in internal fiber structures at high humidity.
The nasal septum and midfacial growth
Authors: Baldwin Michael C. , Zarudnaya Diana , Liu Zi‐Jun , Herring Susan W. 
Published: March 2023

AbstractThe nasal septum is the only element of the chondrocranium which never completely ossifies. The persistence of this nonarticular cartilage has given rise to a variety of theories concerning cranial mechanics and growth of the midface. Previously, using pigs, we demonstrated that the septum is not a strut supporting the snout and that septal growth seems capable of stretching the overlying nasofrontal suture, a major contributor to snout elongation. Here we investigate whether abnormalities of the septum are implicated in cases of midfacial hypoplasia, in which growth of the midface is inadequate. Mild midfacial hypoplasia is common in domestic pig breeds and often severe in the Yucatan minipig, a popular laboratory breed. Normal‐snouted and midfacial hypoplastic heads of standard (farm mixed breed) and minipigs ranging in age from perinatal to 12 months were dissected, imaged by CT, and/or prepared for histology. Even at birth, Yucatan minipigs with midfacial hypoplasia exhibited greater caudal ossification than normal; the ventral cartilaginous sphenoidal “tail” was diminished or missing. In addition, cells that morphologically appeared to have divided recently were less numerous than in newborn standard pigs. Juvenile Yucatan minipigs lacked caudal cartilaginous growth zones almost completely. In standard newborns, the ventral caudal septum was more replicative than the dorsal, but this trend was not seen in Yucatan newborns. In conclusion, accelerated maturation of the caudal septum was associated with midfacial hypoplasia, a further indication that the septum, particularly its ventral portion, is important for midfacial elongation.
Triflate‐Selective Suzuki Cross‐Coupling of Chloro‐ and Bromoaryl Triflates Under Ligand‐Free Conditions
Authors: Ibsen Grace M. , Menezes da Silva Vitor H. , Pettigrew J. Cole , Neufeldt Sharon R. 
Published: March 2023

AbstractIn the absence of strong ancillary ligands such as phosphines or N‐heterocyclic carbenes, palladium salts are selective for C−OTf cleavage in the room‐temperature Suzuki couplings of chloroaryl triflates in acetonitrile. Similar “ligand‐free” conditions in DMSO also promote triflate‐selective Suzuki coupling of bromoaryl triflates. This triflate selectivity complements the typical preference for reaction of bromides in prior reports of Suzuki couplings using phosphine ligands. DFT calculations and additional experimental evidence are consistent with triflate‐selective oxidative addition taking place at homogeneous, possibly mononuclear, anionic palladium supported by a solvent molecule.
Bacterial cellulose: Nature's greener tool for industries
Authors: Katyal Moniya , Singh Rakshanda , Mahajan Ritu , Sharma Anurekha , Gupta Ranjan , Aggarwal Neeraj K. , Yadav Anita 
Published: March 2023

AbstractBacteria are considered mini chemical factories that help us in providing a wide range of products for various purposes. These days, bacterial cellulose (BC) is getting attention by researchers due to its quality, eco‐friendly nature, and excellent physical‐mechanical qualities. It is being used in the fabrication of nanocomposites. Its nanocomposites can be used in various industries, including medicine, food, leather, textiles, environment, electronics, and cosmetics. This area of research is emerging and still in its infancy stage, as new applications are still coming up. Most of the work on BC has been done during the last two decades and serious inputs are required in this direction in order to make the production process commercially viable and ultimately the application part. Biowastes, such as fruits and vegetables wastes, can be used as a cost‐effective medium to minimize the cost for large‐scale production of BC‐based nanocomposites thus will valorize the biowaste material into a valuable product. Using biowaste as media will also aid in better waste management along with reduction in detrimental environmental effects. This review will help the readers to understand the potential applications of BC and its nanocomposites as well as their vital role in our daily lives.
An examination of the relationship between satisfaction with overactive bladder (OAB) treatment and the doctor–patient gender: A questionnaire‐based single‐institution study
Authors: Kouchi Yukiko , Ozaki Akihiko , Kaneda Yudai , Bhandari Divya , Saito Kazuma , Shimmura Hiroaki 
Published: March 2023

AbstractOveractive bladder (OAB) significantly reduces quality of life. The primary goal of this study was to determine whether the gender combination of patient and physician may be associated with satisfaction with OAB treatment. This questionnaire survey was conducted at Jyoban Hospital. We considered the adult patients aged 18 years or older who attended the outpatient office of the urology department of the hospital, were diagnosed with OAB and had been taking anticholinergics or β3‐receptor stimulants, or both, for at least 3 months. In addition to the OAB treatment satisfaction, the questionnaire covered OABSS, IPSS, oral medications, effectiveness of OAB treatment, response to OAB symptoms, and the medium and extent of information collection. A total of 147 patients participated in the study. In summary, 91 (61.9%) were male, and the mean age was 73.5 years. Compared to when the gender of doctor and patient was not the same, female patients tended to be significantly more satisfied when they were treated by female doctors (OR 10.79, 95% CI 1.27–92.05). On the other hand, no similar trend was observed when male patients were treated by male doctors (OR 1.26, 95% CI 0.25–6.34). In the present study, which examined doctor–patient gender combinations in satisfaction with OAB treatment, as hypothesized, satisfaction was higher for female doctor–female patient combinations compared to different doctor–patient genders. A notable fact was that similar associations were not observed among the male doctor–patient combination. This means that an embarrassment of female patients could be stronger than male patients particularly in disclosing urinary symptoms to healthcare providers. The percentage of female urologists in Japan is only 8.2%, and it will be necessary to further promote the recruitment of female doctors in urology fields in order to encourage female patients with OAB to more actively visit doctors.
ESG performance and green innovation: An investigation based on quantile regression
Authors: Long Han , Feng Gen‐Fu , Gong Qiang , Chang Chun‐Ping 
Published: March 2023

AbstractUsing panel data from 37 countries from 1990 to 2019 and applying a quantile regression approach with panel fixed effects, we investigate the impact of national Environmental, Social, and Governance (ESG) performance on green innovation and how this impact varies across different green innovation capacity distributions. The research conclusions are as follows. (1) National ESG performance improvement significantly promotes green innovation. (2) The improvement of environmental performance and governance performance significantly promotes green innovation, but in countries with weak green innovation capabilities, the improvement of social performance reduces the output of green innovation. (3) The role of national ESG performance in promoting green innovation is stronger in countries with weak green innovation capabilities. (4) In non‐high‐income countries, the stronger the green innovation capability is, the more obvious is the promotion of ESG performance to green innovation. The findings of this paper provide empirical evidence and a policy basis for governments to focus on improving ESG performance and to commit to promoting green innovation activities more effectively.
The predictive value of PD‐L1 expression in patients with advanced hepatocellular carcinoma treated with PD‐1/PD‐L1 inhibitors: A systematic review and meta‐analysis
Authors: Yang Yao , Chen Dongbo , Zhao Bigeng , Ren Liying , Huang Rui , Feng Bo , Chen Hongsong 
Published: March 2023

AbstractBackground and AimProgrammed death 1 (PD‐1) and programmed death ligand 1 (PD‐L1) inhibitors have transformed the treatment landscape of advanced hepatocellular carcinoma (HCC), but consistent responses are not observed in all patients, and prognostic biomarkers to guide treatment decisions are lacking. We aimed to evaluate the predictive value of PD‐L1 expression in advanced HCC patients treated with PD‐1/PD‐L1 inhibitors.MethodsA comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted. Studies comparing the objective response rate (ORR) and/or disease control rate (DCR) based on the tumor PD‐L1 status of HCC were included.ResultsEleven studies with 1,330 HCC patients treated with PD‐1/PD‐L1 inhibitors were included. Pooled odds ratio (OR) analysis demonstrated a significantly improved ORR in PD‐L1‐positive patients compared with PD‐L1‐negative patients (OR, 1.86, 95% CI, 1.35–2.55). Similar results were observed in the anti‐PD‐1 treatment (p < 0.001) and anti‐PD‐1/PD‐L1 monotherapy (p < 0.001) subgroups. The pooled ORRs in the PD‐L1‐positive and PD‐L1‐negative groups were 26% (95% CI, 20%–32%) and 18% (95% CI, 13%–22%), respectively. For DCR, the pooled OR analysis showed no significant difference between PD‐L1‐positive patients and PD‐L1‐negative patients (66% [95% CI, 55%–76%] vs. 69% [95% CI, 62%–76%]; OR, 0.92, 95% CI, 0.59–1.44). The results were consistent across the drug target and combination treatment subgroups.ConclusionPositive PD‐L1 expression is associated with a better ORR in advanced HCC patients treated with anti‐PD‐1/PD‐L1‐based therapies. This feature can help to identify HCC patients who will benefit most from PD‐1/PD‐L1 inhibitors.