bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric properties of the Short-Form McGill Pain Questionnaire (SF-MPQ) in adult Mexican cancer patients with chronic pain
Authors: Mendoza-Contreras Luis Alberto , Domínguez Trejo Benjamín , Guillén Núñez María del Rocío , Rodríguez Medina David Alberto , Pardo Xolyanetzin Montero , Estapé Tania , Vázquez Oscar Galindo 
Published: January 2025

Abstract

Background
Pain is a frequent symptom in cancer patients (CP), and its multidimensional assessment is essential for a comprehensive approach and to establish clinical prognoses. The Short-Form McGill Pain Questionnaire (SF-MPQ) is an internationally recognized tool for the multidimensional assessment of pain, both in clinical and research settings. However, no studies have been reported in Latin America that determine its psychometric properties in CP and chronic pain.

Objectives
To determine the psychometric properties of the SF-MPQ in adult Mexican cancer patients with chronic pain.

Methods
An instrumental design was used with a non-probabilistic convenience sample of 222 cancer patients treated at the pain clinic of a tertiary care hospital. Analyses were conducted to evaluate factorial structure (exploratory and confirmatory factor analysis [CFA]), reliability (internal consistency), measurement invariance, and criterion validity (concurrent and divergent).

Results
CFA verified a 9-item structure divided into 2 factors: (1) Affective-Nociceptive and (2) Neuropathic. A global Cronbach’s alpha coefficient of .82 and a global McDonald’s Omega index of .82 were identified. Configural, metric, and scalar invariance (ΔCFI ≤ .01; ΔRMSEA ≤ .015) were confirmed regarding the sex variable. Finally, the SF-MPQ showed a positive correlation with the Numerical Rating Scale (rho = .436, p< .01) and a negative correlation with the EORTC-QLQ C30 (rho = −.396, p< .01).

Significance of results
The Mexican version of the SF-MPQ presented adequate psychometric properties and fit indices, making it a valid and reliable instrument for use in clinical and research settings in Mexico. Its use is recommended for the comprehensive assessment of pain in oncology in Mexico, as it allows for the understanding of pain characteristics beyond intensity, guiding the establishment of clinical prognoses.
Speaking Truth to Power Structures: Integrity and Identity in Ecclesiology
Authors: Percy Martyn 
Published: January 2025

AbstractSpeaking truth ought to be normative in churches, and yet when it does, the foundations and structures of power are often shaken to the core. This paper explores the issues of identity and integrity in ecclesiology and is concerned with the ethical paradigms and moral frameworks that need to be in place if churches are to be places where honesty and truthfulness can be normative. Churches often fail as institutions because they presume they can conduct their affairs as organizations might. Churches become anger-averse, resisting the voices and experiences of victims, in order that the flow of power and its structures are unimpeded. At that point, churches become inherently committed to re-abusing victims and are unable to hear their pain and protests, which only leads to the perpetration of further abuse.
Towards a Safe Church: More Than a Lambeth Call
Authors: King Fergus J. , Banks Alexandra , Sebahene Alfred , Aye Nant Hnin Hnin , Mndolwa Maimbo W.F. , Chama Albert 
Published: January 2025

AbstractThis paper gives definitions of terms which have become critical in ensuring that Anglican churches minimize the risk of harm to all who are involved as practitioners or recipients of its ministries. This imperative is rooted in Scripture, not just the recent history or pronouncements of the Lambeth Conference 2022. The terms ‘Safeguarding’, ‘Safe Ministry’ and ‘Safe Church’ (SC) are set out with reference to the ‘Lambeth Calls’. This paper explores why such terms have come to the forefront of current theological praxis, notes historical iterations of such matters and asks why some Anglican churches or provinces may resist adopting this Lambeth Call. It offers both an apologetic for the universal adoption of SC practices and a scriptural and dominical mandate for them. The paper identifies theological and scriptural principles on which SC theory and practice might be grounded. Anglican churches and provinces are encouraged to develop a theory and practice of SC pertinent to their environment rather than adhere to abstract universal prescriptions which risk irrelevance amidst cultural and contextual particularity.
‘There Isn’t One!’ Church of England Safeguarding Policy
Authors: Stein Josephine Anne 
Published: January 2025

AbstractPolicy and professionalism go hand in hand. When safeguarding policy is all but absent as it is in the Church of England, it leaves clergy and others ill equipped to diagnose or to respond to concerns over abuse. Complex issues such as conflict of interest, evaluation based on verifiable objectives linked to safeguarding priorities, setting a balance between confidentiality and disclosure, safe recruitment and implementing the recommendations of safeguarding reviews are in effect left dangling. Expertise and professional judgement are needed both to develop policy and to apply it in real-world cases of prospective and actual abuse. Statistics about safeguarding cases covering associated resources, expenditure and outcomes are not readily available. Safeguarding reviews, mostly about particular cases, are difficult to generalise and ‘lessons learned’ are typically left at that without evidence of how safeguarding has changed as a result. The focus of safeguarding should be on the welfare of the people concerned, including survivors and perpetrators as well as congregations and church workers. Confrontational and legalistic approaches are all too common and do more harm than good. The objective should be to restore broken relationships, not necessarily between the survivor and the perpetrator, but between everyone involved in the case and the church.
God’s Timelessness, Our Temporal Nature
Authors: Bayer Roberta Lynne 
Published: January 2025

AbstractThe timeless and unchanging nature of God was defended by Dr. Eric Mascall throughout his books. He argued against process theology, and in particular the works of mathematician and philosopher Alfred North Whitehead, who was one of its foremost exponents. In his books, Mascall defended the distinction between our temporal and created nature and God’s divine and uncreated nature as found in historic theology. In a manner suited to his learning, he discussed the implications of modern physics for theology.
Phenological patterns and the impact of seed burial depth and scarification on the emergence and growth of redweed (Melochia corchorifolia)
Authors: Unnikrishnan Dhanu , Raj Sheeja K , Jacob D , Pillai Shalini P , Ameena M , Chauhan Bhagirath Singh 
Published: January 2025

Abstract
Redweed is a tropical, erect branched herb, and one of the predominant broadleaf weeds affecting upland crops in the Onattukara Sandy Plains of Kerala, India. Experiments were conducted in a screenhouse in Thiruvananthapuram, Kerala, India, to determine the effects of seed burial depth and seed scarification on emergence indices and growth attributes of redweed. Scarification stimulated emergence and resulted in greater values for emergence indices and seedling parameters. The seedling emergence of redweed was influenced by seed burial depth. Shallow seed burial (2 cm) of scarified and non-scarified seeds resulted in greater seedling length (70 cm and 58 cm, respectively), seedling biomass (0.72 g and 0.48 g, respectively), emergence percentage (60% and 32%, respectively), and greater values for other emergence indices. As the depth of seed burial increased from 2 cm, emergence and seedling biomass decreased, exhibiting lower values for the emergence indices. Correlation and regression studies revealed that seed burial depth of scarified and non-scarified seeds greater than 2 cm had a negative effect on seedling emergence and biomass of redweed. Weed biology studies indicated that redweed displayed notable consistency in its phenological traits, regardless of the location where the seeds were collected, as little ecotype variability was observed. Emergence occurred in 6 d, 50% flowering in 44 d, capsule formation in 56 d, and maturity in 76 d. On average, a single plant produced 277 seeds and had a 100-seed weight of 0.31 g. A stale seedbed with shallow tillage or deep plowing to a depth of 10 cm before sowing can be adopted to reduce the infestation of redweed.
The mutational landscape of Staphylococcus aureus during colonisation
Authors: Coll Francesc , Blane Beth , Bellis Katherine L. , Matuszewska Marta , Wonfor Toska , Jamrozy Dorota , Toleman Michelle S. , Geoghegan Joan A. , Parkhill Julian , Massey Ruth C. , Peacock Sharon J. , Harrison Ewan M. 
Published: January 2025

Abstract

Staphylococcus aureus is an important human pathogen and a commensal of the human nose and skin. Survival and persistence during colonisation are likely major drivers of S. aureus evolution. Here we applied a genome-wide mutation enrichment approach to a genomic dataset of 3060 S. aureus colonization isolates from 791 individuals. Despite limited within-host genetic diversity, we observed an excess of protein-altering mutations in metabolic genes, in regulators of quorum-sensing (agrA and agrC) and in known antibiotic targets (fusA, pbp2, dfrA and ileS). We demonstrated the phenotypic effect of multiple adaptive mutations in vitro, including changes in haemolytic activity, antibiotic susceptibility, and metabolite utilisation. Nitrogen metabolism showed the strongest evidence of adaptation, with the assimilatory nitrite reductase (nasD) and urease (ureG) showing the highest mutational enrichment. We identified a nasD natural mutant with enhanced growth under urea as the sole nitrogen source. Inclusion of 4090 additional isolate genomes from 731 individuals revealed eight more genes including sasA/sraP, darA/pstA, and rsbU with signals of adaptive variation that warrant further characterisation. Our study provides a comprehensive picture of the heterogeneity of S. aureus adaptive changes during colonisation, and a robust methodological approach applicable to study in host adaptive evolution in other bacterial pathogens.
Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring
Authors: Takao Tomoaki , Matsui Ako , Kikutake Chie , Kan-o Keiko , Inoue Azusa , Suyama Mikita , Okamoto Isamu , Ito Minako 
Published: January 2025

Abstract
The root of asthma can be linked to early life, with prenatal environments influencing risk. We investigate the effects of maternal asthma on the offspring’s lungs during fetal and adult life. Adult offspring of asthmatic mothers show an increase in lung group 2 innate lymphoid cell (ILC2) number and function with allergen-induced lung inflammation. Offspring of asthmatic mothers show phenotypic alteration of their lung ILC2s during fetal life, with increased expression of genes related to activation and glucocorticoid signaling. Furthermore, these offspring carry overlapping chromatin-accessible altered regions, including glucocorticoid receptor-binding regions in their lung ILC2s both at the fetal stage and adulthood, suggesting persistent prenatal epigenetic changes. Moreover, maternal exposure to glucocorticoids has similar effects on fetal lung ILC2s and contributes to allergen-induced lung inflammation during adulthood. Thus, asthma during pregnancy may have long-term effects on lung ILC2s in the offspring from the embryonic period, contributing to an increased risk of developing asthma.
Assessing the impact of energy coaching with smart technology interventions to alleviate energy poverty
Authors: Llewellyn Joseph , Venverloo Titus , Duarte Fabio , Ratti Carlo , Katzeff Cecilia , Johansson Fredrik , Pargman Daniel 
Published: January 2025

Abstract
Energy poverty affects 550,000 homes in the Netherlands yet policy interventions to alleviate this issue are rare. Therefore, we test two energy coaching interventions in Amsterdam: a static information group (n = 67) which received energy efficient products and one energy-use report, and a smart information group (n = 50), which also had a display providing real-time feedback on energy-use. Results across both groups, show a 75% success rate for alleviating energy poverty. On average homes reduced monthly electricity consumption by 62 kWh (33%), gas by 41 m3 (42%), bills by €104 (53%) and percentage of income spent on energy from 10.1% to 5.3%.
Illuminating the impact of CD38-induced adenosine formation in B-cell lymphoma
Authors: Zaiema Shams ElDoha Galal ElDin , Hafez Heba Mohamed Saber , El-Ela Diaa El-Din Moussa Sherif Abou , Saad Rawda Ahmed Alaaeldin Ahmed Mohamed 
Published: January 2025

Abstract
The expression of CD38 by cancer cells may mediate an immune-suppressive effect by producing Extracellular Adenosine (ADO) acting through G-protein-coupled cell surface receptors on cellular components and tumor cells. This can increase PD-1 expression and interaction with PD-L1, suppressing CD8 + cytotoxic T cells. This study examines the impact of heightened CD38 expression and extracellular ADO on various hematological and clinical parameters in patients with mature B-cell lymphoma, alongside their correlation with the soluble counterparts of the PD-1/PD-L1 axis. Our study was conducted on 90 patients, CD38-positive and CD38-negative (measured by flow cytometry), with mature B-cell lymphoma divided into CLL and B-NHL subtypes. Their serum ADO, soluble PD-1, and PD-L1 levels were measured using a sandwich ELISA. Our study revealed a positive correlation between CD38 expression, sADO, sPD-1, and sPD-L1 in mature B-cell lymphoma patients. CD38-positive patients had higher sADO, sPD-1, and sPD-L1 levels. Higher CD38 expression and extracellular ADO negatively affected HB level and PLT count and positively correlated with the higher risk stratification in mature B-cell lymphoma patients. This study explored the potential impact of CD38 expression and elevated extracellular ADO on B-cell lymphoma alongside their link with the PD-1/PD-L1 axis. Our findings underscore the influence of extracellular ADO on the neoplastic process of mature B-cell lymphoma. We also propose targeting the CD38-induced-ADO formation pathway, which could serve as a promising therapeutic immune target with multifaceted effects within mature B-cell neoplasms.
Strong immune responses and robust protection following a novel protein in adjuvant tuberculosis vaccine candidate
Authors: Korompis Marcellus , De Voss Christopher J , Li Shuailin , Richard Alexandre , Almujri Salem Salman , Ateere Alberta , Frank Géraldine , Lemoine Céline , McShane Helen , Stylianou Elena 
Published: January 2025

Abstract
BCG remains the only licensed vaccine for tuberculosis (TB), but its efficacy wanes over time. Subunit vaccines, aim to improve BCG immunity and protection, by inducing responses to a few mycobacterial antigens delivered with a specific platform. Since the platform shapes the immune response induced, selecting the right platform has been challenging due to the lack of immune correlates of protection. Recently, the protein-adjuvated subunit vaccine. M72/AS01E, demonstrated 49.7% efficacy in preventing active TB in latently infected adults, indicating that protective immunity through subunit vaccines is possible. In this study we evaluated the immunogenicity and efficacy of the promising mycobacterial antigen PPE15, formulated with five adjuvants developed by the Vaccine Formulation Institute. While all adjuvants were immunogenic, PPE15 with LMQ protected vaccinated mice against an in vivo Mycobacterium tuberculosis challenge, both as a standalone vaccine and as a boost to BCG. Vaccinated mice had enriched lung parenchymal antigen-specific CD4 + CXCR3 + KLRG1− T cells previously associated with TB protection. Heterologous vaccination strategies were also explored by combining intranasal ChAdOx1.PPE15 viral vector, with intramuscular PPE15-LMQ resulting in improved protection compared to individual vaccines. These findings support the progression of this vaccine candidate to the next stages of development.
Efficient adsorptive removal of Congo Red dye using activated carbon derived from Spathodea campanulata flowers
Authors: Sudarsan Sujesh , Murugesan Gokulakrishnan , Varadavenkatesan Thivaharan , Vinayagam Ramesh , Selvaraj Raja 
Published: January 2025

Abstract
This report investigates the preparation, characterization, and application of activated carbon derived from Spathodea campanulata flowers (SCAC) to remove Congo Red (CR) dye from aqueous streams. SCAC was synthesized using orthophosphoric acid activation which yielded a mesoporous material with a specific surface area of (986.41 m2/g), significantly exceeding values reported for flower-derived activated carbons in the available literature. Field emission scanning electron microscopy (FESEM) image revealed an irregular, rough surface morphology pre-adsorption, which became smoother post-adsorption, indicating successful CR attachment. Elemental analysis through energy-dispersive x-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS) confirmed an increase in carbon content and the appearance of sulfur, verifying CR uptake. Adsorption kinetics obeyed the pseudo-second-order equation, signifying chemisorption, while the equilibrium dataset fitted better to the Langmuir model, with R2 of 0.9944, suggesting a monolayer adsorption mechanism with a maximum adsorption capacity of 59.27 mg/g. Thermodynamic analysis revealed spontaneous and endothermic adsorption process. Desorption studies showed methanol as the most effective desorbing agent, with SCAC retaining considerable adsorption capacity across six cycles, highlighting its reusability. In tests with real water matrices, SCAC demonstrated significantly higher removal efficiency in natural waters than control, suggesting enhanced adsorption in complex matrices. These findings underscore the practical applicability of SCAC in real-world wastewater treatment, offering a promising solution for large-scale industrial applications.
Spermine driven water deficit tolerance in early growth phases of sweet corn genotypes under hydroponic cultivation
Authors: Zargar Tahoora Batool , Sobh Mawia , Basal Oqba , Janda Tibor , Pál Magda , Veres Szilvia 
Published: January 2025

Abstract
Sweet corn is highly susceptible to water deprivation, making it crucial to identify effective strategies for enhancing its tolerance to water deficit conditions. This study investigates the novel application of Spermine as a bio-stimulant to improve sweet corn (Zea mays L. var. saccharata) resilience under hydroponic water deficit conditions. Four genotypes (Dessert, Messenger, Tyson, and Royalty) were treated with Spermine (0.2 mM foliar application), polyethylene glycol 6000 (8% and 12%), and their combinations. The impacts on growth parameters, photosynthetic performance, and oxidative stress markers were evaluated. Spermine significantly enhanced biomass parameters, counteracting the severe reductions caused by PEG-induced water deprivation. In the Dessert and Tyson genotypes, total biomass increased by 145%, while it increased by 118% in Messenger and 110% in Royalty when treated with Spermine under severe water deprivation. However, Spermine treatment application did not recorded higher differences compared to control under non water deficit conditions. In the Dessert genotype, root length increased by 36.6% under combined treatment compared to 12% PEG alone. Spermine also mitigated reductions in shoot length, improved by 90.6% and specific leaf area, with a notable 272.6% increase in Tyson under severe water deficit. Photosynthetic performance, including chlorophyll and carotenoid levels, was enhanced, with a 103.1% increase in relative chlorophyll content in Dessert under severe water deprivation. Spermine also reduced oxidative damage, as indicated by a 48.7% decrease in malondialdehyde levels in Tyson, and increased peroxidase activity, enhancing antioxidant defense in Messenger under severe water deprivation. The quantum efficiency of Photosystem II, which was significantly reduced by water deficit, showed substantial improvement with Spermine treatment, with increases of 107.2% in Tyson and 99.4% in Royalty under moderate water deprivation. These results highlight the potential of Spermine as an effective strategy to improve sweet corn resilience under water-limited conditions, offering a novel approach for sustainable crop management.
Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake
Authors: Bajunaid Rania , Niu Chaoqun , Hambly Catherine , Liu Zongfang , Yamada Yosuke , Aleman-Mateo Heliodoro , Anderson Liam J. , Arab Lenore , Baddou Issad , Bandini Linda , Bedu-Addo Kweku , Blaak Ellen E. , Bouten Carlijn V. C. , Brage Soren , Buchowski Maciej S. , Butte Nancy F. , Camps Stefan G. J. A. , Casper Regina , Close Graeme L. , Cooper Jamie A. , Cooper Richard , Das Sai Krupa , Davies Peter S. W. , Dabare Prasangi , Dugas Lara R. , Eaton Simon , Ekelund Ulf , Entringer Sonja , Forrester Terrence , Fudge Barry W. , Gillingham Melanie , Goris Annelies H. , Gurven Michael , El Hamdouchi Asmaa , Haisma Hinke H. , Hoffman Daniel , Hoos Marije B. , Hu Sumei , Joonas Noorjehan , Joosen Annemiek M. , Katzmarzyk Peter , Kimura Misaka , Kraus William E. , Kriengsinyos Wantanee , Kuriyan Rebecca , Kushner Robert F. , Lambert Estelle V. , Lanerolle Pulani , Larsson Christel L. , Leonard William R. , Lessan Nader , Löf Marie , Martin Corby K. , Matsiko Eric , Medin Anine C. , Morehen James C. , Morton James P. , Must Aviva , Neuhouser Marian L. , Nicklas Theresa A. , Nyström Christine D. , Ojiambo Robert M. , Pietiläinen Kirsi H. , Pitsiladis Yannis P. , Plange-Rhule Jacob , Plasqui Guy , Prentice Ross L. , Racette Susan B. , Raichlen David A. , Ravussin Eric , Redman Leanne M. , Reilly John J. , Reynolds Rebecca , Roberts Susan B. , Samaranayakem Dulani , Sardinha Luis B. , Silva Analiza M. , Sjödin Anders M. , Stamatiou Marina , Stice Eric , Urlacher Samuel S. , Van Etten Ludo M. , van Mil Edgar G. A. H. , Wilson George , Yanovski Jack A. , Yoshida Tsukasa , Zhang Xueying , Murphy-Alford Alexia J. , Sinha Srishti , Loechl Cornelia U. , Luke Amy H. , Pontzer Herman , Rood Jennifer , Sagayama Hiroyuki , Schoeller Dale A. , Westerterp Klaas R. , Wong William W. , Speakman John R. 
Published: January 2025

Abstract
Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years. The resultant regression equation predicts expected TEE from easily acquired variables, such as body weight, age and sex, with 95% predictive limits that can be used to screen for misreporting by participants in dietary studies. We applied the equation to two large datasets (National Diet and Nutrition Survey and National Health and Nutrition Examination Survey) and found that the level of misreporting was >50%. The macronutrient composition from dietary reports in these studies was systematically biased as the level of misreporting increased, leading to potentially spurious associations between diet components and body mass index.