bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population growth of Tetranychus truncatus (Acari: Tetranychidae) on different drought-tolerant potato cultivars
Authors: Zhang Ke-Xin , Ma Yue , Li Chun-Chun , Quandahor Peter , Haq Inzamam Ul , Zhang Qiangyan , Kong Li-Li , Tao Yan , Liu Chang-Zhong 
Published: March 2023

Abstract
Tetranychus truncatus Ehara (Acari: Tetranychidae) has become one of the major phytophagous pests in China in recent years, and is found on a wide range of host plants. However, little information is available on the population performance of this arthropod pest on potatoes. In this study, we explored the population growth of T. truncatus on two drought-tolerant potato (Solanum tuberosum L.) cultivars under laboratory conditions using the age-stage, two-sex life table. Tetranychus truncatus completed its entire life history on both potato cultivars tested, Holland 15 and Longshu 10. There was no significant difference between two potato cultivars in developmental duration. Tetranychus truncatus had shorter adult longevity (20.61 days), adult female longevity (20.41 days), and total female longevity (33.66 days) on Longshu 10 than Holland 15 (21.16 days, 21.19 days, and 34.38 days, respectively). However, it exhibited a higher preadult survival rate, higher fecundity (F = 88.32 eggs per female), and relatively higher population parameters when reared on Longshu 10 than on Holland 15 (F = 75.70 eggs per female). Growth projection also showed that the population size of T. truncatus on Longshu 10 (expand 750-fold) was larger than that on Holland 15 (expand 273-fold) after 60 days. Our results demonstrate that the drought-sensitive potato variety, Holland 15, is relatively resistant to T. truncatus compared with the drought-tolerant variety, Longshu 10, and suggest that T. truncatus exhibited a trade-off between longevity and reproduction on both potato cultivars. Our findings provide information on population prediction, which may aid the management of this pest mite species of potatoes.
Potential risk to pollinators from neonicotinoid applications to host trees for management of spotted lanternfly,Lycorma delicatula(Hemiptera: Fulgoridae)
Authors: Elmquist Jonathan , Biddinger David , Phan Ngoc T , Moural Timothy W , Zhu Fang , Hoover Kelli 
Published: March 2023

AbstractNeonicotinoid insecticides are used to manage spotted lanternfly (Lycorma delicatula (White); hereafter SLF), a recently introduced pest in the United States. Neonicotinoids can harm nontargets, such as pollinators potentially exposed via floral resources of treated plants. We quantified neonicotinoid residues in whole flowers of two SLF host plant species, red maple (Acer rubrum L. [Sapindales: Sapindaceae]) and tree-of-heaven (Ailanthus altissima (Mill.) [Sapindales: Simaroubaceae]), treated with post-bloom imidacloprid or dinotefuran applications that differed in timing and method of application. In red maple flowers, dinotefuran residues from fall applications were significantly higher than summer applications, while imidacloprid residues from fall applications were significantly lower than summer applications. Residues did not differ between application methods or sites. In tree-of-heaven flowers, dinotefuran residues were only detected in one of 28 samples at a very low concentration. To assess acute mortality risk to bees from oral exposure to residues in these flowers, we calculated risk quotients (RQ) using mean and 95% prediction interval residue concentrations from treatments in this study and lethal concentrations obtained from acute oral bioassays for Apis mellifera (L. (Hymenoptera: Apidae)) and Osmia cornifrons (Radoszkowski (Hymenoptera: Megachilidae)), then compared these RQs to a level of concern. For A. mellifera, only one treatment group, applied at 2X maximum label rate, had an RQ that exceeded this level. However, several RQs for O. cornifrons exceeded the level of concern, suggesting potential acute risk to solitary bees. Further studies are recommended for more comprehensive risk assessments to nontargets from neonicotinoid use for SLF management.
Clio in the Operating Theatre: Historical Research, Emotional Health, and Surgical Training in Contemporary Britain
Authors: Arnold-Forster Agnes 
Published: March 2023

Abstract
Drawing on my experience working as a postdoctoral research and engagement fellow on the Wellcome Trust-funded project, Surgery & Emotion, this article reflects on this innovative model of historical research and professional engagement, explores the challenges posed by crossing disciplinary boundaries, and interrogates the practical and theoretical utility of bringing historical research into the operating theatre. How do surgeons specifically engage with the history of their profession? What can the history of emotions offer to the training of medical students and surgeons? What obstacles interfere in this type of cross-disciplinary engagement? What peculiar opportunities and challenges do the United Kingdom higher education system and National Health Service pose to the teaching of medical history in clinical settings?
Bringing Clio into the operating theatre provides surgeons with an alternative narrative to that which they have come to expect about the emotions they ought to feel and express in their work. It allows them to explore the high feelings of their professional lives at a remove and offers an array of possible solutions to the current emotional health crisis in British medicine. History allows surgeons to imagine an alternative world: one where the pervasive and persistent models of emotional detachment – damaging to both patient experience and professional wellbeing – dissolve.
Endoscopic iliopsoas lengthening for treatment of recalcitrant iliopsoas tendinitis after total hip arthroplasty
Authors: Bonano John C , Pierre Kinsley , Jamero Christopher , Segovia Nicole A , Huddleston James I , Safran Marc R 
Published: March 2023

ABSTRACTIliopsoas (IP) tendinitis from impingement upon the acetabular component after total hip arthroplasty (THA) has been treated with open and endoscopic IP tenotomy or acetabular component revision. This study describes the results of a consecutive series of patients treated with endoscopic IP tenotomy as a less invasive alternative. Twenty-eight patients with IP impingement after THA underwent endoscopic IP lengthening from 2012 to 2021 at a single-center academic institution. The follow-up of 24 of these patients was achieved with a mean follow-up of 7.6 months (range 1–28). Outcomes included the modified Harris Hip Score (mHHS), visual analog pain scale (VAS), satisfaction, component positioning and complications. Seventy-one percent of patients were satisfied or very satisfied after their operation. The median mHHS preoperatively was 57 (Interquartile range [IQR] 43–60) and postoperatively was 75 (IQR 66–92, P &lt; 0.001). Clinically meaningful improvements in mHHS were seen in patients with VAS pain scores &lt;5, cup prominence &gt;8 mm, body mass index &gt;30, and less than 2 years from their index THA. Two patients developed a deep infection 7 and 10 months postoperatively (neither related to the release), and one patient underwent open psoas release for persistent impingement. Endoscopic IP tenotomy is a safe and effective treatment for impingement after THA. Patients with cup prominence &gt;8 mm, body mass index &gt;30 and less than 2 years since their index THA may have more clinically meaningful improvements in pain and function.
A Climate Change Carve-Out for Investment Treaties
Authors: Paine Joshua , Sheargold Elizabeth 
Published: March 2023

ABSTRACT
This article responds to the growing risk of Investor–State Dispute Settlement (ISDS) claims arising from states’ measures to mitigate climate change, such as fossil fuel phase-outs. It proposes a carve-out that would cover measures that are adopted in good faith and have a reasonable causal nexus with reducing and stabilizing greenhouse gas emissions (e.g. measures ‘related to’ this aim). Depending on states’ preferences, the carve-out could be designed as a treaty-wide exclusion from international investment agreements (IIAs) or as a carve-out that only removes such measures from ISDS procedures. Importantly, we propose a process to govern the application of the carve-out that prevents this issue being determined by ISDS tribunals. We argue that questions concerning the carve-out’s application to specific investor claims should initially be subject to joint determination by the treaty parties’ environmental authorities. Where these authorities cannot agree, we propose that this issue should be referred to a State–State tribunal that includes members with climate-related expertise. This article advances the specific debate about a climate carve-out for IIAs and wider debates about strategies for protecting regulatory space under IIAs through its detailed examination of carve-outs, drawing on examples from a range of subject areas.
hCINAP alleviates senescence by regulating MDM2 via p14ARF and the HDAC1/CoREST complex
Authors: Huang Xinping , Zhao Yan , Wei Min , Zhuge Ruipeng , Zheng Xiaofeng 
Published: March 2023

Abstract
Cellular senescence is a major process affected by multiple signals and coordinated by a complex signal response network. Identification of novel regulators of cellular senescence and elucidation of their molecular mechanisms will aid in the discovery of new treatment strategies for aging-related diseases. In the present study, we identified human coilin-interacting nuclear ATPase protein (hCINAP) as a negative regulator of aging. Depletion of cCINAP significantly shortened the lifespan of Caenorhabditis elegans and accelerated primary cell aging. Moreover, mCINAP deletion markedly promoted organismal aging and stimulated senescence-associated secretory phenotype in the skeletal muscle and liver from mouse models of radiation-induced senescence. Mechanistically, hCINAP functions through regulating MDM2 status by distinct mechanisms. On the one hand, hCINAP decreases p53 stability by attenuating the interaction between p14ARF and MDM2; on the other hand, hCINAP promotes MDM2 transcription via inhibiting the deacetylation of H3K9ac in the MDM2 promoter by hindering the HDAC1/CoREST complex integrity. Collectively, our data demonstrate that hCINAP is a negative regulator of aging and provide insight into the molecular mechanisms underlying the aging process.
On the potential in film for ethics education: in defence of educational ethicism
Authors: MacAllister James 
Published: March 2023

ABSTRACT
In this paper the potential in film for ethics education is considered, and the theory of educational ethicism is defended. Some key features of ethicism are firstly outlined. Bery’s Gaut’s argument about how artworks may teach ethics in an aesthetically meritorious way is also discussed. Two objections (from Matthew Kieran and Andrea Sauchelli) to Gaut’s position are then considered. It is argued that Gaut’s ethicism is not well placed to overcome these objections. However, I draw upon Paul Hirst to explain why a refined species of ethicism (educational ethicism) can surmount these objections. Educational ethicism holds that artworks with ethical themes be regarded as starting points for conversations about ethics rather than conveyers of definite ethical teachings that only a normatively specified audience can grasp. Three ways that film can possess potential for ethics education are also documented: through the moral growth of the audience, by helping them to deepen understanding of an aspect of ethical experience, and in developing theoretical understanding.
Plant community traits and functions mediate the biomass trade-off of alpine grasslands along precipitation gradients on the Tibetan Plateau
Authors: Sun Le , Sun Jian , Wu Jun-Xi , Du Zi-Yin , Chen You-Jun , Wang Yi , Liu Miao , Li Wen-Cheng , Liang Er-Yuan 
Published: March 2023

AbstractA better understanding the mechanisms driving plant biomass allocation in different ecosystems is an important theoretical basis for illustrating the adaptive strategies of plants. To date, the effects of habitat conditions on plant biomass allocation have been widely studied. However, it is less known how plant community traits and functions (PCTF) affect biomass allocation, particularly in alpine grassland ecosystems. In this study, community-weighted means (CWM) were calculated at the community level using five leaf functional traits, and the relationships between PCTF and biomass trade-offs were explored using correlation analysis, variation partitioning analysis and structural equation modeling. We found that the trade-off values were greater than zero in both alpine meadow (AM) and alpine steppe (AS) across the Tibetan Plateau, with different values of 0.203 and 0.088 for AM and AS, respectively. Moreover, the critical factors determining biomass allocation in AS were species richness (SR; scored at 0.69) and leaf dry matter content of CWM (CWMLDMC, scored at 0.42), while in AM, the key factors were leaf dry matter content (CWMLDMC, scored at 0.48) and leaf carbon content of CWM (CWMLC, scored at −0.45). In particular, both CWMLDMC and SR in AS, as well as CWMLDMC and CWMLC in AM were primarily regulated by precipitation. In summary, precipitation tends to drive biomass allocation in alpine grasslands through its effects on PCTF, hence highlighting the importance of PCTF in regulating plant biomass allocation strategies along precipitation gradients.
Urine and Saliva Viral Load in Children with Congenital Cytomegalovirus Infection
Authors: Kabani Nazia , Pinninti Swetha , Boppana Suresh , Fowler Karen , Ross Shannon 
Published: March 2023

Abstract
Viral load in infant saliva and urine was assessed to predict sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection. Viral load was higher in symptomatic infants. Viral load in asymptomatic children with and without SNHL did not differ. Congenital cytomegalovirus infection viral load in urine and saliva does not predict hearing loss.
Synthalin: a lost lesson for glucagon suppression in diabetes therapeutics
Authors: Thomas Keith G , Klempel Natalie J , Flatt Peter R , Bailey Clifford J , Moffett R Charlotte 
Published: March 2023

Abstract

Objectives
Within mammalian pancreatic islets, there are two major endocrine cell types, beta-cells which secrete insulin and alpha-cells which secrete glucagon. Whereas, insulin acts to lower circulating glucose, glucagon counters this by increasing circulating glucose via the mobilisation of glycogen. Synthalin A (Syn A) was the subject of much research in the 1920s and 1930s as a potential pancreatic alpha-cell toxin to block glucagon secretion. However, with the discovery of insulin and its lifesaving use in patients with diabetes, research on Syn-A was discontinued.

Key findings
This short review looks back on early studies performed with Syn A in animals and humans with diabetes. These are relevant today because both type 1 and type 2 diabetes are now recognised as states of not only insulin deficiency but also glucagon excess.

Summary
Lessons learned from this largely forgotten portfolio of work and therapeutic strategy aimed at limiting the number or function of islet alpha-cells might be worthy of reconsideration.
APETx2 regulates intestinal motility and visceral sensitivity in post-infectious irritable bowel syndrome mice through 5-HT signalling pathway
Authors: Yuan Liping , Xiao Hongyun , Li Huan , Yan Bo 
Published: March 2023

Abstract

Objectives
To investigate whether APETx2, a potent and selective inhibitor of ASIC3, regulates intestinal motility and visceral sensitivity in post-infectious irritable bowel syndrome (PI-IBS) mice through the 5-HT signalling pathway.

Methods
The PI-IBS model was established by Trichinella spiralis infection of NIH mice. APETx2(120 µg/kg) was administrated to PI-IBS mice by intraperitoneal injection once a day, lasting for 7 days. The gastrointestinal function of mice was assessed by the time of the first dark stool and the number of pellets defecated within 2 h. The visceral sensitivity was tested via abdominal withdrawal reflex. The protein levels of 5-HT and CRF in colon tissues were detected by immunohistochemistry. The changes in serum 5-HT and colon CRF contents were detected by ELISA. The mRNA levels of colon 5-HT4R and CRF were detected by RT-qPCR. The protein levels of colon 5-HT4R and dorsal root ganglion (DRG) ASIC3 were detected by Western blotting.

Key findings
The results indicated that APETx2 could markedly improve gastrointestinal function and visceral sensitivity in mice. Moreover, APETx2 could reduce the expression level of ASIC3 protein in the DRG of PI-IBS mice. APETx2 could increase the expression levels of 5-HT in serum and colon, CRF and 5-HT4R in the colon, and 5-HT4R in brain tissue in PI-IBS mice.

Conclusions
APETx2 can improve visceral sensitivity and intestinal motility in PI-IBS through 5-HT signalling pathway.
Post-infectious irritable bowel syndrome following a diagnosis of traveller’s diarrhoea: a comprehensive characterization of clinical and laboratory parameters
Authors: España-Cueto Sergio , Oliveira-Souto Inés , Salvador Fernando , Goterris Lidia , Treviño Begoña , Sánchez-Montalvá Adrián , Serre-Delcor Núria , Sulleiro Elena , Rodríguez Virginia , Aznar Maria Luisa , Bosch-Nicolau Pau , Espinosa-Pereiro Juan , Pou Diana , Molina Israel 
Published: March 2023

AbstractBackgroundProlonged or recurrent gastrointestinal symptoms may persist after acute traveller’s diarrhoea (TD), even after adequate treatment of the primary cause. This study aims to describe the epidemiological, clinical and microbiological characteristics of patients with post-infectious irritable bowel syndrome (PI-IBS) after returning from tropical or subtropical areas.MethodsWe conducted a retrospective study of patients presenting between 2009 and 2018 at the International Health referral centre in Barcelona with persistent gastrointestinal symptoms following a diagnosis of TD. PI-IBS was defined as the presence of persistent or recurrent gastrointestinal manifestations for at least 6 months after the diagnosis of TD, a negative stool culture for bacterial pathogens and a negative ova and parasite exam after targeted treatment. Epidemiological, clinical and microbiological variables were collected.ResultsWe identified 669 travellers with a diagnosis of TD. Sixty-eight (10.2%) of these travellers, mean age 33 years and 36 (52.9%) women, developed PI-IBS. The most frequently visited geographical areas were Latin America (29.4%) and the Middle East (17.6%), with a median trip duration of 30 days (IQR 14–96). A microbiological diagnosis of TD was made in 32 of these 68 (47%) patients, 24 (75%) of whom had a parasitic infection, Giardia duodenalis being the most commonly detected parasite (n = 20, 83.3%). The symptoms persisted for a mean of 15 months after diagnosis and treatment of TD. The multivariate analysis revealed that parasitic infections were independent risk factors for PI-IBS (OR 3.0, 95%CI 1.2–7.8). Pre-travel counselling reduced the risk of PI-IBS (OR 0.4, 95%CI 0.2–0.9).ConclusionsIn our cohort, almost 10% of patients with travellers’ diarrhoea developed persistent symptoms compatible with PI-IBS. Parasitic infections, mainly giardiasis, seem to be associated with PI-IBS.
Decarbonizing the GCC: sustainability and life after oil and in GCC countries
Authors: Truby Jon 
Published: March 2023

Abstract
Energy transition and decarbonization in the Gulf Cooperation Council (GCC) is crucial to achieving Sustainable Development Goal (SDG) 7 and global climate objectives. This article first highlights the serious impact of the imminent and longer-term threats to the Gulf region caused by rising temperatures and climate change risks. As a shared problem, the article analyses how countries in the GCC are individually and collectively responding to the rising threat, by exploring the recent revised 2020 Nationally Determined Contributions delivered in advance of Conference of the Parties 26, as well as climate and energy targets. On this basis, the article evaluates the legal strategies to decarbonize energy and switch to cleaner economies. The article also highlights how clean energy transitions can help deliver environmental and economic dividends, and achieve a sustainable economy envisioned in SDG7.
Nutrient availability regulates Deschampsia antarctica photosynthetic and stress tolerance performance in Antarctica
Authors: Gago Jorge , Nadal Miquel , Clemente-Moreno María José , Figueroa Carlos María , Medeiros David Barbosa , Cubo-Ribas Neus , Cavieres Lohengrin Alexis , Gulías Javier , Fernie Alisdair Robert , Flexas Jaume , Bravo León Aloys 
Published: March 2023

Abstract
Deschampsia antarctica is one of the only two native vascular plants in Antarctica, mostly located in the ice-free areas of the Peninsula’s coast and adjacent islands. This region is characterized by a short growing season, frequent extreme climatic events, and soils with reduced nutrient availability. However, it is unknown whether its photosynthetic and stress tolerance mechanisms are affected by the availability of nutrients to deal with this particular environment. We studied the photosynthetic, primary metabolic, and stress tolerance performance of D. antarctica plants growing on three close sites (&lt;500 m) with contrasting soil nutrient conditions. Plants from all sites showed similar photosynthetic rates, but mesophyll conductance and photobiochemistry were more limiting (~25%) in plants growing on low-nutrient availability soils. Additionally, these plants showed higher stress levels and larger investments in photoprotection and carbon pools, most probably driven by the need to stabilize proteins and membranes, and remodel cell walls. In contrast, when nutrients were readily available, plants shifted their carbon investment towards amino acids related to osmoprotection, growth, antioxidants, and polyamines, leading to vigorous plants without appreciable levels of stress. Taken together, these findings demonstrate that D. antarctica displays differential physiological performances to cope with adverse conditions depending on resource availability, allowing it to maximize stress tolerance without jeopardizing photosynthetic capacity.