bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sperm parameters in Israeli transgender women before and after cryopreservation
Authors: Barda Shimi , Amir Hadar , Mizrachi Yossi , Dviri Michal , Yaish Iris , Greenman Yona , Sofer Yael , Azem Foad , Hauser Ron , Lantsberg Daniel 
Published: December 2022

AbstractBackgroundThe application of fertility preservation, initially intended for oncological patients prior to gonadotoxic treatment, has extended in recent years to transgender and gender‐non‐conforming individuals undergoing therapy for gender compatibility.ObjectivesTo examine semen quality and survival in transgender women pursuing semen cryopreservation in the presence or absence of gender‐affirming hormonal medication.Materials and methodsIn this retrospective cohort study, we reviewed data of 74 consecutive transgender women presenting for semen cryopreservation at a single center between 2000 and 2019. Semen parameters before and after cryopreservation were compared to a control group composed of 100 consecutive sperm bank donor candidates. A subgroup analysis of subjects who had used gender‐affirming hormonal treatment was also performed.ResultsCompared to the control group, transgender women had lower total sperm count (144.0 vs. 54.5 million, respectively, p < 0.001), lower sperm motility percentage (65.0% vs. 51.0%, respectively, p < 0.001), and lower total motile sperm count (94.0 vs. 27.0 million, respectively, p < 0.001). Values were further decreased in transgender women who had received hormonal treatment before sperm cryopreservation. Post‐thawing motility rate remained lower in the transgender group compared to the control group (20.0% vs. 45.0%, respectively, p < 0.001), and the total motile count remained lower as well (2.7 vs. 9.0 million, respectively, p < 0.001). Following sperm cryopreservation, the post‐thaw decreases in total motile sperm count were higher in the transgender group compared with the control group (91.5% vs. 90.0%). Further subdivision in the transgender group showed that the decrease in total motile sperm count was lower for transgender women who did not use gender‐affirming hormonal treatment compared to those who did (−89.7% vs. −92.6%, respectively, p < 0.01).Discussion and conclusionSperm parameters in transgender women are poor compared to candidates for sperm donation representing the general population. Specimens collected after discontinuation of gender‐affirming hormone treatments were further impaired. Moreover, post‐thawing sperm total motile count, motility, and overall sperm survival were reduced in transgender women.
Secular trend and urban–rural disparity for age at spermarche among Chinese Han boys from 1995 to 2019
Authors: Shi Di , Ma Ning , Liu Yunfei , Dang Jiajia , Zhong Panliang , Cai Shan , Hu Peijin , Ma Jun , Song Yi , Lau Patrick W. C. 
Published: December 2022

AbstractAimTo examine the secular trend and the urban–rural disparity of spermarche among Chinese Han boys from 1995 to 2019.MethodsA total of 392 775 boys of Han ethnicity aged 11–18 years were extracted from the 1995, 2000, 2005, 2010, 2014 and 2019 Chinese National Surveys on Students' Constitution and Health. The median age at spermarche was estimated using the status quo data and probit analysis. The chi‐square, ANOVA and LSD tests were used to compare the differences between the year‐subgroups. U‐test was used to compare the difference between urban and rural areas at each year.ResultsThe median age at spermarche in Chinese Han boys decreased from 14.6 years in 1995 to 13.9 years in 2019 (p < 0.001). The rural boys showed a faster decreasing pace with a 1‐year advance of age at spermarche while the urban boys had only a 0.5‐year decrement, and there was still a statistically significant difference between urban–rural areas in 2019 (p < 0.001). Similar to urban–rural disparity, the age gap at spermarche between areas with different urbanisation rates became smaller over time.ConclusionsIn general, spermarche in Chinese Han boys showed a decreasing trend, but the pace was slowing down. The urban–rural disparity in puberty development still existed but was gradually narrowing.
Improved respiratory parameters with skin‐to‐skin contact in premature infants with bronchopulmonary dysplasia on NIV‐NAVA
Authors: Serrano‐Llop Ana , De‐Rooy Laura , Duffy Donovan , Kulkarni Anay , Shetty Sandeep 
Published: December 2022

AbstractAimTo determine if skin‐to‐skin contact (SSC) improved respiratory parameters in premature infants with evolving or established bronchopulmonary dysplasia (BPD) on non‐invasive neutrally adjusted ventilator assist (NIV‐NAVA).MethodsPremature infants (<32 weeks gestational age) with BPD on NIV‐NAVA were studied. Continuous readings from the Edi catheter (modified nasogastric feeding tube inserted for NAVA ventilation) were compared: pre‐SSC (baby in incubator) and end‐SSC (just before end of SSC).ResultsSixty‐five episodes of SSC were recorded in 12 premature infants with median gestational age at birth of 24.4 (23.1–27.0) weeks and birth weight of 642 (530–960) grams. Peak Edi (uV) in end‐SSC 11.5 (2.7–38.7) was significantly lower compared to pre‐SSC 15.8 (4.0–36.6), p < 0.001. P mean (cmH2O) was significantly lower in end‐SSC 9.7 (7.3–15.4) compared to pre‐SSC 10.3 (7.5–15.5), p = 0.008. Respiratory rate (breaths/min) was significantly lower in end‐SSC 52.9 (31.1–78.1) compared to pre‐SSC 53.4 (35.1–74.1), p = 0.031. There was no significant difference in inspired oxygen requirement or time on back‐up mode in end‐SSC 40.0 (22.1–56.1) and 5.9 (0.0–56.0) compared to pre‐SSC 39.0 (26.0–56.1) and 5.1 (0.0–29.3), p = 0.556 and p = 0.853 respectively.ConclusionSSC improved respiratory parameters in premature infants with evolving or established BPD on NIV‐NAVA.
E‐commerce adoption among Moroccan agricultural cooperatives: Between structural challenges and immense business performance potential
Authors: Jabbouri Imad , Jabbouri Rachid , Bahoum Karim , El Hajjaji Yasmine 
Published: December 2022

AbstractThis paper explores the barriers that Moroccan agricultural cooperatives face in adopting E‐commerce and the perceived impact this approach would hae on their business performance. We surveyed 120 Moroccan agricultural cooperatives and interviewed 13 cooperative presidents to collect both quantitative and qualitative data. We use descriptive and inferential statistics including independent t‐tests, One‐way ANOVA and post‐hoc analysis for quantitative data while we use thematic analysis for qualitative analysis. We document that the most important barrier to the adoption of E‐commerce in Moroccan agricultural cooperatives is the lack of information related to the low digital literacy of the cooperatives in question. Further, cooperatives believe that E‐commerce will have the highest impact on their brand image and competitiveness but will have the lowest impact on operating speed. Our results show that the higher the level of digitalization the higher the perceived impact of E‐commerce on business performance of Moroccan cooperatives. Our study provides a basis for understanding the challenges faced by Moroccan agricultural cooperatives in adopting E‐commerce. Our results can be used to craft policies and programs that ease the integration of this segment into the digital ecosystem of Morocco.
A moderated mediation effect of symbolic and substantive preventive actions on employees’ preventive behavior in the context of Covid‐19
Authors: Nawaz Asif , Soomro Shuaib Ahmed , Batool Samar , Rani Hira , Aslam Arsalan 
Published: December 2022

AbstractThis study utilizes Social Information Processing (SIP) theory to investigate the relationship between organizational preventive actions (substantive vs. symbolic), employee preventive behavior, the mediating role of conspiracy beliefs, and moderating role of leadership integrity in the context of Covid‐19. The study explains leadership integrity as a boundary condition to facilitate or hinder the mediated relationship between organizational actions and employee preventive behavior (EPB). The hypothesized model was tested using partial least square structural equation modeling (PLS‐SEM) on two‐wave data collected from 281 respondents. The results revealed that substantive actions do not predict EPB directly but through conspiracy beliefs. Contrary to these, symbolic actions negatively predict EPB directly. Leadership integrity moderates the relationship between substantive actions and conspiracy beliefs, while the interaction effect with symbolic actions is not supported. The findings of this study caution managers to walk their talk because employees critically observe the most apparent actions, especially when management fails to practice them. The study contributes to social information processing theory by pointing to leadership integrity as a source of authenticity to curb the negative impact of symbolic actions and catalyst the effect of substantive actions on employee preventive behavior.
Effects of ABCB1 polymorphisms on the transport of ponatinib into the cerebrospinal fluid in Japanese Philadelphia chromosome‐positive acute lymphoblastic leukaemia patients
Authors: Fukushi Yayoi , Akamine Yumiko , Abumiya Maiko , Tozawa Nagi , Yamashita Takaya , Nara Miho , Kameoka Yoshihiro , Takahashi Naoto , Miura Masatomo 
Published: December 2022

The effects of polymorphisms of ABCB1 and ABCG2 on the dose‐adjusted plasma trough concentrations and cerebrospinal fluid (CSF)‐to‐plasma ratios of ponatinib were evaluated. Blood (C4) and CSF (CSF4) concentrations at 4 h after administration were determined. The median (95% confidence interval) CSF4‐to‐C4 ratio of ponatinib in subjects homozygous for ABCB1 variants 1236T/T, 2677T/T + T/A or 3435T/T were significantly higher than that in a group of subjects with other genotypes (P = .026, .012 and .015, respectively). The median (95% confidence interval) CSF4‐to‐C4 ratio of ponatinib in 4 patients with the combination of ABCB1 variants 1236T/T‐2677T/T + T/A‐3435T/T was 2.62% (1.42–3.42%); this ratio was significantly higher than that in subjects with other genotypes (1.08% [0.89–1.47%]; P = .006). The brain distribution of ponatinib was affected by ABCB1 polymorphisms and therefore seems to be modulated by P‐glycoprotein at the blood–brain and blood–CSF barriers.
Relapse patterns in early‐PET negative, limited‐stage Hodgkin lymphoma (HL) after ABVD with or without radiotherapy–a joint analysis of EORTC/LYSA/FIL H10 and NCRI RAPID trials
Authors: Fiaccadori Valeria , Neven Anouk , Fortpied Catherine , Aurer Igor , Andre Marc , Federico Massimo , Counsell Nicholas , Phillips Elizabeth H. , Clifton‐Hadley Laura , Barrington Sally F. , Illidge Timothy , Radford John , Raemaekers John M. M. 
Published: December 2022

SummaryIn the H10 and RAPID randomised trials, chemotherapy+radiotherapy (combined modalities treatment, CMT) was compared with chemotherapy (C) in limited‐stage Hodgkin lymphoma (HL), with negative early positron emission tomography (ePETneg). We analysed patterns of relapses in the H10 trial, validated findings in the RAPID trial and performed a combined analysis stratified by trial. The impact of radiotherapy (RT) on risk of relapse was studied using adjusted Cox models, with time‐varying effects. In H10, 1,059 ePETneg patients were included (465 European Organisation for Research and Treatment of Cancer (EORTC) favourable [F], 594 unfavourable [U]). Among the F patients, 2/227 (1%) relapsed after CMT, 30/238 (13%) after C: of these relapses, 21/30 (70%) occurred in less than 2 years and 25/30 (83%) affected originally involved areas. Among the U group, 16/292 (5%) relapsed after CMT: 8/16 (50%) in less than 2 years, 11/16 (69%) in originally involved areas. After C 30/302 (10%) relapsed: 27/30 (90%) in less than 2 years, and 26/30 (87%) in originally involved areas. Similar results were observed in 419 ePETneg RAPID patients (241 F, 128 U, 50 unclassified): among F patients, 6/118 (5%) relapsed after CMT; 13/123 (11%) after C: 11/13 (85%) in less than 2 years and 11/13 (85%) affecting originally involved areas. In U patients, 3/65 (5%) relapsed after CMT and 5/63 (8%) after C. In both trials, omitting RT in ePETneg HL resulted in more early relapses, mainly affecting originally involved areas. RT significantly reduced risk of early relapses in the combined stratified analysis.
SARS‐CoV‐2 infection and vaccination in patients with hairy‐cell leukaemia
Authors: Tiacci Enrico , Mancini Alessandro , Marchetti Monia , D'Elia Gianna Maria , Candoni Anna , Morotti Alessandro , Romano Alessandra , Gozzetti Alessandro , Broccoli Alessandro , De Carolis Luca , Bruna Riccardo , Tisi Maria Chiara , Selleri Carmine , Capponi Monia , Vallisa Daniele , Cattaneo Chiara , Della Porta Matteo Giovanni , Busca Alessandro , Falini Brunangelo , Massaia Massimo , Bertù Lorenza , Pulsoni Alessandro , Rivela Paolo , Corradini Paolo , Passamonti Francesco 
Published: December 2022

SummaryLittle is known of the course of COVID‐19 and the antibody response to infection or vaccination in patients with hairy‐cell leukaemia (HCL). Among a total of 58 HCL cases we studied in these regards, 37 unvaccinated patients, mostly enjoying a relatively long period free from anti‐leukaemic treatment, developed COVID‐19 between March 2020 and December 2021 with a usually favourable outcome (fatality rate: 5/37, 14%); however, active leukaemia, older age and more comorbidities were associated with a worse course. Postinfection (n = 11 cases) and postvaccination (n = 28) seroconversion consistently developed, except after recent anti‐CD20 or venetoclax therapy, correlating with perivaccine B‐cell count. Vaccination appeared to protect from severe COVID‐19 in 11 patients with breakthrough infection.
Maintenance therapy in multiple myeloma: Two is not always better than one
Authors: Offidani Massimo , Morè Sonia , Corvatta Laura 
Published: December 2022

In multiple myeloma (MM) long‐term therapy aims to control disease and delay progression for as long as possible. In this issue Jenner et al. failed to demonstrate a benefit of maintenance with lenalidomide plus vorinostat compared with lenalidomide in both transplant eligible (TE) and ineligible (NTE) patients enrolled in the Myeloma XI trial.Commentary on: Jenner et al. The addition of vorinostat to lenalidomide maintenance for patients with newly diagnosed multiple myeloma of all ages: results from ‘Myeloma XI’, a multicentre, open‐label, randomised, phase III trial. Br J Haematol. 2023;201:276‐288.
Space‐for‐time substitution reveals a hump‐shaped distribution of dung beetles
Authors: Ancco‐Valdivia Fernando Geronimo , Calixto Eduardo Soares , López‐Tejeda Evaristo 
Published: December 2022

AbstractUnraveling how climate change impacts the diversity and distribution patterns of organisms is a major concern in ecology, especially with climate‐sensitive species, such as dung beetles. Often found in warmer weather conditions, beetles are used as bio‐indicators of environmental conditions. By using an altitudinal gradient as a proxy for climate change (i.e., space‐for‐time substitution), we assessed how changes in climatic variables, such as temperature and precipitation, impact patterns of dung beetle diversity and distribution in the Peruvian Andes. We recorded dung beetle diversity using three different types of baits, feces, carrion, and fruits, distributed in 18 pitfall traps in five different altitudinal sites (from 900 to 2500 m, 400 m apart from each other) in the rainy and dry season. We found that (i) dung beetle richness and abundance were influenced by the climate gradient, (ii) seasonality influenced beetle richness, which was high in the wet season, but did not influence abundance, (iii) dung beetle richness and abundance fit to a hump‐shaped distribution pattern along the altitudinal gradient, and (iv) species richness is the beta‐diversity component that best describes the composition of dung beetle species along the altitudinal gradient. Our data show that the distribution and diversity of dung beetles are different at larger scales, with different patterns resulting from the response of species to both abiotic and biotic factors.Abstract in Spanish is available with online material.
Parents, teens and screens during COVID‐19 containment: An exploratory study
Authors: Surís Joan‐Carles , Berchtold André , Barrense‐Dias Yara 
Published: December 2022

AbstractObjectiveOne of the main concerns of parents is the amount of screen time of their teenagers, and most of them try to set rules about it. The objective of this exploratory study was to compare whether parents' rules changed during confinement and whether these changes were successful.MethodsWe studied a group of parents (N = 47) of 13‐year‐olds in Switzerland surveyed before and during the COVID‐19 pandemic.ResultsMost parents (83%) indicated that screen‐time rules for their teens had changed during containment, mainly to be less strict. Although only a minority of parents were successful in defining screen‐time spaces or schedules for their teenagers, almost three out of four were successful when they encouraged non‐screen‐based activities.ConclusionsThis exploratory study reveals that, during containment, parents decided to be less strict with their teens' screen‐time use even though it remained their main worry. However, it also suggests that when activities non‐involving screens are proposed, teens are likely to participate. These results seem to indicate that reducing screen time is not a matter of imposing restrictions but, rather, of proposing alternatives. Finally, further research is warranted to assess whether these changes in screen‐time use are exceptional or here to stay.
Genomic characterization of thymic epithelial tumors reveals critical genes underlying tumorigenesis and poor prognosis
Authors: Tan Sheng , Chen Jili , Wang Zheng , Zhao Xiaokai , Sun Yonghua , Zhu Youcai , Gong Ziying , Zhang Daoyun 
Published: December 2022

AbstractThymic epithelial tumors (TETs) are rare mediastinal tumors whose tumorigenesis mechanism is poorly understood. Characterization of molecular alterations in TETs may contribute to a better understanding of tumorigenesis and prognosis. Hybrid capture‐based next‐generation sequencing was performed on tumor tissues from 47 TETs (39 thymomas and 8 thymic carcinomas) to detect mutations in 315 tumor‐associated genes. In total, 178 nonsynonymous mutations were identified, with a median of 3.79 per tumor in 47 TETs. Higher tumor mutation burden (TMB) level was more common in older TET patients, and significantly associated with the more advanced pathological type, especially in thymic carcinomas (TC) patients. The gene mutation profiles of B1‐3, A/AB, and TC patients varied greatly. In the actionable mutations analysis, we found 32 actionable mutations in 24 genes. Among them, NFKBIA and TP53 mutations was the most frequently, which were only identified in TCs. Additionally, TCGA database analysis found that the expression of NFKBIA mRNA in the TCs were significantly higher than thymomas. TET patients with high NFKBIA expression had shorter overall survival compared with patients with low/medium NFKBIA expression, thus providing insights to consider NFKBIA as a potential prognosis biomarker and therapeutic target in TETs.
Lung transplantation from donation after circulatory death, evolution, and current status in the United States
Authors: Furukawa Masashi , Noda Kentaro , Chan Ernest G. , Ryan John P. , Coster Jenalee N. , Sanchez Pablo G. 
Published: December 2022

AbstractBackgroundThe number of lung transplants from donors after circulatory death has increased over the last decade. This study aimed to describe the evolution and outcomes following lung transplantation donation after circulatory death (DCD) and report the practices and outcomes of ex vivo lung perfusion (EVLP) in this donor population.MethodsThis was a retrospective study using a prospectively collected national registry. The United Network for Organ Sharing (UNOS) database was queried to identify adult patients who underwent lung transplantation between May 1, 2005, and December 31, 2021. Kaplan–Meier analysis and Weibull regression were used to compare survival in four cohorts (donation after brain death [DBD] with or without EVLP, and DCD with or without EVLP). The primary outcome of interest was patient survival.ResultsOf the 21 356 recipients who underwent lung transplantation, 20 380 (95.4%) were from brain death donors and 976 (4.6%) from donors after circulatory death. Kaplan–Meier analysis showed no difference in the survival time between the two groups. In a multivariable analysis that controlled for baseline differences in donor and recipient characteristics, recipients who received lungs from cardiac death donors after EVLP had 28% shorter survival time relative to donor lungs after brain death without EVLP (hazard ratio [HR] 1.53, 95% confidence interval [CI] 1.10–2.15, p = .01).ConclusionsThe early survival differences observed after lung transplants from donors after circulatory death in lungs evaluated with EVLP deserves further investigation.
Disrupting Museum Authority: Art, Voice and the Museum
Authors: Lawrenson Anna , O'Reilly Chiara 
Published: December 2022

AbstractMuseums are wrestling with their past and exhibitions provide important spaces to create new dialogues and include previously excluded voices. This review examines two exhibitions from 2021 at museums in Sydney, Australia – Unsettled at the Australian Museum and Eucalyptusdom at the nearby Museum of Applied Arts and Sciences – as these exhibits are significant markers of fundamental changes in Australian museum practice. It examines how these museums sought to disrupt the colonial bias in their historical collections and tell new stories of settlement and place. It considers the way that voice, particularly the voice of Indigenous communities and creative practitioners helped to challenge how history could be told and the authority of the museums.
Injection drug use in an affluent beachside community in Sydney: An exploratory qualitative study
Authors: Dertadian George Christopher , Caruana Theresa , Maher Lisa 
Published: December 2022

AbstractIntroductionSocial research on injection drug use has focussed on marginalised groups and communities, leaving a large gap in the field's understanding of how it is experienced in other settings, including in relatively affluent communities.MethodsThis research is based on fieldwork and 18 in‐depth qualitative interviews conducted in suburban beach‐side communities in Sydney collectively known as the Northern Beaches.ResultsParticipants did not experience stigmatisation by local health services as the norm or as a deterrent to access. Drug acquisition on the Northern Beaches occurred among closed networks of friends and acquaintances, and injecting use rarely occurred in public settings. Police contact was minimal, resulting in lower levels of criminalisation.Discussion and ConclusionsUnlike many of the participants featured in the literature, our study participants grew up in middle and upper middle‐class households, typically experiencing comfortable childhoods with little to no exposure to injection drug use. In this setting injection drug use operates covertly within the normal rhythms of middle‐class life, hidden in amongst the bustle of cafés and shopping centres, and through the friendliness of neighbourhood driveway and doorstep interactions. Drug use is described as common in the area, with injecting behaviours stigmatised in ways that set it against the ‘good’ families and neighbourhoods of this beach‐side enclave. In contrast to much of the Australian qualitative literature which frames injection drug use as a means of psychological relief or a subcultural norm, our participants described injecting as motivated by the desire to enhance pleasure and social connection.