bluuebunny/crossref_metadata_2025_split huggingface dataset:
CBCT and Micro-CT analysis of the mandibular first premolars with C-shaped canal system in Chinese population
Authors: Zhang Yimeng , Weng Xunben , Fu Yu , Qi Xuekai , Pan Yihuai , Zhao Yu 
Published: March 2023

Abstract
Purpose The purpose of this study was to determine the prevalence of C-shaped root canal system in mandibular first premolar in Chinese population and to analyze the anatomical characteristics by Cone-beam computed tomography (CBCT) and Micro–computed tomography (Micro-CT) together.
Methods CBCT images of 760 patients (1520 mandibular first premolars) were evaluated for the prevalence of C-shaped root canal system and the correlation with gender, age and position. 66 mandibular first premolars with C-shaped root canal system were scanned by Micro-CT and analyzed for morphologic features of the root canal anatomy (radicular groove, C-shaped root canal categories, accessory and connecting canals, apical foramina and accessory foramina).
Results C-shaped root canal system was found in 16.9% of mandibular first premolars. The minimum mesial wall thickness was mostly measured at the lingual site (69.7%). Among the cross-sectional C-shaped root canal system classifications, the highest prevalence was C2 type (41.5%). In the 3D C-shaped root canal system classification, the highest prevalence was S type (34.8%). Accessory canals were observed in 48.5% of the samples, mostly in the middle region. The presence of 1-3 variable connecting canals was observed in 42.4% of the samples. The number of apical foramina was predominantly 1 (40.9%).
Conclusions The incidence of C-shaped root canal system in mandibular first premolars was 16.9% in the Chinese population. It mostly had anatomical features such as deep root surface grooves, with C2 type and S type being the most prevalent.
Bach Mai Procedure with Combining Approach and Early Resection of The Terminal Ileum for Total Laparoscopic Right Hemicolectomy: A prospective study
Authors: NGUYEN Ngoc Hung , VU Xuan Vinh , NGUYEN Vu Quang , NGUYEN The Hiep , Du NGUYEN Huy , LUONG Tuan Hiep 
Published: March 2023

Abstract
Purpose. Total laparoscopic right hemicolectomy with complete mesocolic excision (CME), central vascular ligation (CVL) and D3 lymphadenectomy is still the most challenging colon procedures for gastrointestinal surgeons. We herein report the technical details and our preliminary experience of Bach Mai Procedure - a novel combining approach and early resection of the terminal ileum.
Methods. The Dissection Stage was central vascular isolation and ligation by a combined multiple approaches in the following four steps: (Cranial approach) dissecting along the inferior aspect of pancreatic isthmus to reveal the middle colic vessels and the anterior aspect of the superior mesentery vein, then exposed the right gastroepiploic vein and the trunk of Henle; (Medial-to-lateral approach) exposing the surgical axis - the superior mesenteric vascular axis, then early resection of the terminal ileum to open the dissection from the bottom up; (Caudal approach) radical ligation of the ileocecal artery and right colic artery (central vascular ligation), lymph node dissection (D3 lymphadenectomy) and (Lateral-to-medial approach) resecting the Toldt fascia of the colon to release the entire right colon from the abdominal wall.
Results. In 12 months, there were 32 cases of primary right-sided colon malignancies that have undergone tLRHD3, CME/CVL based on the novel combining approach and early resection of the terminal ileum. In 3 cases (9.4%), the tumor site was hepatic flexure. The median of lymph node number (LNN) was 38, with the maximum number was 101. No serious postoperative complications (grade III or higher) neither in-hospital mortality was detected.
Conclusion. This novel combining approach and early resection of the terminal ileum is technically feasible and safe for tLRHD3, CME/CVL. Further investigations and follow-up must be proceeded to evaluate the long-term outcomes of our technique.
Is Sortilin an indicator of subclinical atherosclerosis in patients with psoriasis?
Authors: Tas-Aygar Gamze , Cevirgen-Cemil Bengu , Kaplanoglu Hatice , Eren Ayse Arzu , Gonul Muzeyyen 
Published: March 2023

Abstract
Introduction: Systemic comorbidities are quite common in psoriasis, which is a chronic inflammatory disease. These comorbidities are important causes of mortality and morbidity. Atherosclerosis and related cardiovascular events are important causes of death at an early age. Atherosclerosis is a condition that can be detected by radiological examination. We aimed to evaluate the role of serum sortilin as possible markers for subclinical atherosclerosis in patients with psoriasis.
Methods: Serum levels of sotilin was measured by ELISA in 33 psoriasis patients and in 33 healthy controls. Waist circumference and body mass index of both groups were recorded; Fasting plasma glucose(FPG), HOMA-IR, serum lipid and sortilin levels were measured. Carotid and femoral intima-media thicknesses (CIMT, FIMT) were measured by USG. Demographic characteristics, the severity of psoriasis (PASI), age of onset, total duration and presence of nail involvement of patients included in the study were recorded.
Results: The mean serum sortilin level was 6.20 ± 3.11 ng / mL in the patient group and 7.82 ± 4.97 ng / mL in the control group. There was no statistically significant difference between serum sortilin levels in both groups (p = 0.729). There was no statistically significant relationship between serum levels of sortilin and disease severity (p = 0.597). The right and left CIMT values of the patients were significantly higher than the controls (p = 0.012, p = 0.020). There was no significant difference between the two groups in terms of FIMT values. There was a statistically significant relationship between serum sortilin levels and right CIMT in patients (p = 0.031).
Discussion: The positive correlation between the level of sortilin and the right CIMT in our patient group confirmed that sortilin may be an indicator of subclinical atherosclerosis in psoriasis patients.
Optimization of Sand Parameters to Improve the Quality of Cast Iron Using Taguchi
Authors: Nenzhelele Rendani , Madzivhandila Takalani 
Published: March 2023

Abstract
The main aim of the foundry industries is to produce quality castings with no rejection. In addition, in the present era of global competition, manufacturing industries has bound to take the challenge that is demand for high quality product with reduced lead–time. However, with the diversity of greensand casting parameters, it results in varying effects on the quality.
With sand being one of the most frequent cause of quality reject/rework, it is essential to understand the effect it has on the casting outcome. Taguchi’s approach in quality states that the quality of a product is dependent on the input, he figured that the perfect time to eliminate differences in products is during the designing and manufacturing of products, he developed a strategy for quality that can be used in process. Therefore, it is important to understand the inputs in sand mould preparation.
The focus of the research is on greensand moulding process. The casting defect is the most contributing factor to quality reject in most foundries. The sand moulding process is the most contributing factor to the formation scrap. The target in foundries is to achieve low casting defects at minimum cost.
It is essential to select significant parameters that cause variation of quality characteristic of castings .data should be collected dictated by the chosen orthogonal array (OA) and parameter levels. With the collected at the analysis of variance (ANOVA) can be generated to determine the statistical importance of parameter and response graphs are plotted to determine the optimum setting of control parameter
Do Users Adopt Extremist Beliefs from Exposure to Hateful Subreddits?
Authors: Schmitz Matheus , Muric Goran , Hickey Daniel , Burghardt Keith 
Published: March 2023

Abstract
Social media offers an avenue for like-minded individuals to interact in ways that were previously not possible. Yet, it can also be a breeding ground for hate and extremism to spread. Despite research into hate speech on social media, its influence on users adopting extremist beliefs is less understood. In this study we use causal analysis to quantify extremist adoption resulting from users becoming active in hateful online communities known as \textit{subreddits}. Using an Interrupted Time Series research design, we compare users who became involved in hateful subreddits (treatment group) to those who did not (control group). This analysis is reproduced across ten different subreddits covering four different topics: Alt-Right, Racism, Sexism, Fat-Shaming. From these analyses we uncover a causal link between a user becoming active in a hateful community and using more hate speech both within hateful subreddits and across the wider platform. The results are consistent and replicate across communities. Our findings are tentative evidence that users adopt extremist ideas from exposure to hateful subreddits.
Tremor and Paradoxical bronchospasm caused by Terbutaline
Authors: Wang Deyan , Liu Jinping , Liang Bin , Zhang Jing , Zhou Ya , Zhang Xu 
Published: March 2023

AbstractBackground Common adverse reactions of terbutaline include skeletal muscle tremor, headache,tachycardia, palpitations, hypokalemia and so on.Bronchospasm caused by terbutaline is rarely reported. This article reports one case of severe bronchospasm caused by nebulized terbutaline sulfate inhalation therapy. Case presentation A 51-year-old female patient was admitted to hospital with acute bronchitis.The main complaints were cough, sputum and wheezing. She has no history of drug or food allergies. On the day of admission, terbutaline nebulization treatment immediately caused limb tremor and bronchospasm. After glucocorticoid, aminophylline, non-invasive respiratory support and other symptomatic treatments,the patient improved on the 4th day. Conclusion The mechanism of terbutaline leading to bronchospasm is still unclear. The tert-butylline on the chemical structure of terbutaline may bind to proteins to produce IgE-mediated bronchospasm, The excipient ededidine disodium and the osmotic pressure of the nebulized diluent may also lead to bronchospasm. During the clinical treatment, hypotonic nebulizing dilutions should be avoided, and close monitor should be taken in case ofpossible fatal bronchospasm.
Need to adopt scaled decentralized systems in the water infrastructure to achieve sustainability and build resilience
Authors: Kalbar Pradip P. , Lokhande Shweta 
Published: March 2023

Abstract
Urban water infrastructure (UWI) in cities faces enormous pressure to cope with increased water demands, handle extreme events and improve the service with minimum resource consumption and environmental impacts. The current study presents an approach for addressing the challenges in UWI, specifically in water supply and sewerage. The article argues a need for a paradigm shift that simultaneously includes the sustainability and resilience aspects throughout the life cycle of UWI. The article further highlights the issues in the prevailing approach of centralized infrastructure and demonstrates the necessity of moving away from such an approach and shifting towards decentralized infrastructure. Understanding the factors accelerating decentralization to attain a paradigm shift to decentralization is necessary. Hence, the study first identifies the drivers of decentralization. Secondly, the need for an appropriate scale to be considered while implementing decentralized UWI is highlighted in this study. Furthermore, the effect of the scale of infrastructure is discussed through the trade-offs between life-cycle costs, ease of governance, resilience and recycling benefits. The approach of scaled decentralization outlined in the study will be useful for developing countries to plan new infrastructure and also for developed countries to replace the ageing UWI to create future sustainable and resilient urban systems
Decreasing dietary nitrogen consumption improves wastewater treatment efficiency and carbon footprint
Authors: Rautiainen Nea , Rantanen Pirjo-Liisa , Jalava Mika , Mikola Anna 
Published: March 2023

Abstract
This article aimed to connect protein consumption with the nitrogen load to wastewater treatment plants (WWTPs) in Finland. The influence of the changes in nitrogen consumption on the WWTP environmental footprint was estimated using process simulation. As the main result, a connection was found between nitrogen loads from food consumption and the incoming load to a WWTP. This was done by analysing protein consumption data from the Food and Agriculture Organization of the United Nations (FAO) and incoming nitrogen load data from the Finnish environmental institute, SYKE. The impact of nitrogen consumption was estimated using different diet scenarios. Decreasing dietary nitrogen consumption by 16–24% could decrease nitrous oxide emissions by 16–24% and aeration energy (AE) consumption by 6–11%. An increase in dietary nitrogen consumption of 6–42% could increase AE consumption by 2–14% when effluent requirements were met. When considering the environmental impact of this increased aeration, it corresponds to an increase of 2–16%. Furthermore, nitrous oxide emissions could rise by 6–42% This information can be valuable to WWTPs and even consumers for influencing incoming nitrogen loads.
Enhancing stormwater management with low impact development (LID): a review of the rain barrel, bioretention, and permeable pavement applicability in Indonesia
Authors: Putri Fidyasari Kusuma , Hidayah Entin , Ma'ruf Mokhammad Farid 
Published: March 2023

Abstract
Low impact development (LID) is a sustainable land use and planning strategy that aims to minimize the environmental impacts of development. A community can enhance their water resources and create sustainable and resilient neighbourhoods. This approach has demonstrated success in managing stormwater and promoting water reuse globally, however, its suitability in developing countries like Indonesia remains uncertain and requires further investigation. The implementation of LID in developing countries may face several challenges including high density and complex drainage networks, combined sewer usage, clay soil type, irregular housing layouts, community socio-economic characteristics, affordability, cost, and the availability of regulations and policies. With proper planning and site-specific strategies, LID can be implemented effectively in Indonesia. Clear regulations, secured funding source and community-based LID are all essential for successful LID deployment. This paper can be used as a starting point for considering LID implementation in Indonesia and other countries with similar characteristics.
Features of a Balanced Healthy Diet with Cardiovascular and Other
Benefits
Authors: Manolis Antonis A. , Manolis Theodora A. , Melita Helen , Manolis Antonis S. 
Published: March 2023

Background:
Cardiovascular (CV) disease (CVD) remains the leading cause of death globally.
Besides lack of exercise, obesity, smoking, and other risk factors, poor nutrition and unhealthy/
unbalanced diets play an important role in CVD.

Objective:
This review examined data on all issues of the CV-health benefits of a balanced diet, with
tabulation of nutritional data and health-authority recommendations and pictorial illustration of the main
features of a CV-healthy diet.

Methods:
PubMed and Google Scholar were searched for relevant studies and reviews on diet and CV
health.

Results:
For a long time, there has been evidence, corroborated by recent findings, that pro-vegetarian
diets have a beneficial influence on serum lipid levels, markers of inflammation and endothelial function,
prooxidant-antioxidant balance, and gut microbiome, all probably contributing to reduced CV risk.
Worries about the nutritional adequacy of vegetarian diets are circumvented by obtaining certain nutrients
lacking or found in lower amounts in plants than in animal foods, by consuming a wide variety of
healthy plant foods and through intake of oral supplements or fortified foods. Well-balanced diets, such
as the Mediterranean or the Dietary-Approaches-to-Stop-Hypertension diets, provide CV-health benefits.
Nevertheless, a broad variety of plant-based diets with low/minimal animal food intake may allow
for a personalized and culturally adjusted application of dietary recommendations contributing to the
maintenance of CV health.

Conclusion:
Universal adoption of a balanced CV-healthy diet can reduce global, CV and other mortality
by ~20%. This requires world-wide programs of information for and education of the public, starting
with school children and expanding to all groups, sectors, and levels.
Synthesis and Biological Evaluation of Paclitaxel-aminoguanidine
Conjugates for Suppressing Breast Cancer
Authors: Dai Yi , Zhang Yang , Zhang Lvfeng , Song Zurong 
Published: March 2023

Background:
A combination of paclitaxel with antineoplastic agents or paclitaxel
alone was used clinically for the treatment of metastatic breast cancer. However, paclitaxel has
poor water solubility and limited effect on some metastatic breast cancers. Hence, novel
paclitaxel derivatives are in demand. In addition, the inducible nitric oxide synthase inhibitor,
and aminoguanidine has a synergistic antitumor effect with chemotherapeutics.

Objective:
This study aims to design and synthesize the paclitaxel-aminoguanidine conjugates.
Upon cellular internalization, the novel paclitaxel-aminoguanidine conjugates could release
paclitaxel and aminoguanidine with the aid of esterase and weak acids in cancer cells.

Methods:
Paclitaxel-aminoguanidine conjugates were synthesized using click chemistry. The
biological activity of paclitaxel-aminoguanidine conjugates was evaluated by MTT assay,
determination of nitric oxide, analysis of apoptosis and cell cycle, and wound healing assay.

Results:
Here, a novel paclitaxel-aminoguanidine conjugate was synthesized using click chemis-try. Compared with paclitaxel, the water solubility of paclitaxel-aminoguanidine conjugates increased obviously. Upon cellular internalization, the novel paclitaxel-aminoguanidine conjugates released paclitaxel and aminoguanidine to synergistically inhibit the proliferation and metastasis of breast cancer cells with the aid of esterase and weak acids in cancer cells. The results of the MTT assay showed that compared with paclitaxel or the mixture of paclitaxel and aminoguanidine, the cytotoxicity of compound 4 against 4T1 cells was enhanced. As for apoptosis induced by these compounds, the paclitaxel-aminoguanidine conjugates also had a stronger ability to induce apoptosis than paclitaxel or the mixture of paclitaxel and aminoguanidine. The results of the scratch test showed that the anti-metastatic effect of the con-jugate was the strongest among these tested compounds.

Conclusion:
These findings indicate that paclitaxel-aminoguanidine conjugate is a promising
anticancer agent worthy of further study.
Chlorogenic Acid Inhibits Proliferation, Migration and Invasion of
Pancreatic Cancer Cells via AKT/GSK-3β/β-catenin Signaling Pathway
Authors: Chen Xiaoliang , Liu Binyu , Tong Jiale , Bo Jianing , Feng Miao , Yin Lili , Lin Xiukun 
Published: March 2023

Background:
Chlorogenic acid (CA, United States Patent No. 10772340), a natural
biologically active food ingredient, displays potent antitumor activity against a variety of cancer
cells. However, the mechanism underlying its anticancer effect is not well elucidated.

Objective:
In the present study, we hope to dissect the mechanism underlying the anticancer effects
of CA in pancreatic cancer cells.

Methods:
The cytotoxicity of CA in pancreatic cancer cells was determined by MTT assay. Flow
cytometry was performed to evaluate the cells apoptosis, while a clonogenic assay was carried out
to check the colony formation of cancer cells. Transwell assay was performed to assess the cells
migration and invasion. The protein expression of AKT/GSK-3β/β-catenin signaling pathway was
detected by Western Blot.

Results:
Our data indicated that CA inhibited the proliferation of PANC-28 and PANC-1 cells in a
dose and time-dependent manner. CA was able to inhibit colony formation, migration, and invasion
ability and trigger apoptosis in PANC-28 and PANC-1 cells. Further study showed that CA
down-regulated the expression of AKT, p-AKT(Thr308), p-GSK-3β(Ser9), β-catenin, N-cadherin,
and vimentin while enhancing the expression of cleaved-caspase 3 and cleaved-caspase 7 in
PANC-28 and PANC-1 cells.

Conclusion:
Our study provides significant evidence that CA is able to inhibit the growth of pancreatic
cancer via the AKT/GSK-3β/β-catenin signaling pathway.
Human Blood Grup and Rhesus Detection Tool Prototype Design Based On IoT
Authors: Hendrawati Trisiani Dewi , Hasanudin Inzaghi 
Published: March 2023

Currently, medical practitioners carry out blood type and rhesus examinations by directly observing the agglutination reaction and depending on the examiner's eye. Meanwhile, the effects of eye fatigue and saturation will cause inaccurate data. Therefore, a detection device was made which aims to display information about reading human blood type and rhesus on a digital display which can also store the data into a database. The ABO and rhesus systems were used in this study. This research was made using a real-time method based on the internet of things (IoT). sending data in real-time using WiFi Module ESP-01 and other components such as LCD microcontroller, LDR, LED, battery, and Arduino Uno. based on the results of tool testing, the percentage of success values is 91.67%.