bluuebunny/crossref_metadata_2025_split huggingface dataset:
The AIDS and Cancer Specimen Resource (ACSR): HIV malignancy specimens and data available at no cost
Authors: Silver Sylvia , Schmelz Monika 
Published: August 2023

AbstractThe goal of the AIDS and Cancer Specimen Resource (ACSR) is to play a major role in the advancement of HIV/AIDS cancer-related research/treatment by providing richly annotated biospecimens and data to researchers at no cost. The ACSR acquires, stores, and equitably distributes these samples and associated clinical data to investigators conducting HIV/AIDS-related research, at no costs. Currently, it is the only biorepository of human biospecimens from people with HIV and cancer available to eligible researchers globally who are studying HIV associated malignancies.This review describes the history and organizational structure of the ACSR, its types of specimens in its inventory, and the process of requesting specimens. In addition, the review provides an overview of research that was performed over the last 5 years with its support and gives a summary of important new findings acquired by this research into the development of cancers in people with HIV, including both Aids-related and non-Aids-related malignancies.
Rescue therapy with an albuvirtide-based antiretroviral regimen in an HIV-infected child with multidrug resistance and multiple opportunistic infections: a case report
Authors: Tang Wei , Song Xiao-yun , Cao Jing , Liu Chun , Zheng Fang 
Published: August 2023

Abstract
Background
Managing multidrug-resistant (MDR) HIV infections in children is particularly challenging due to the lack of experience with new drugs in the pediatric setting. Second-line albuvirtide (ABT) with an optimized antiretroviral background therapy was approved for adults and adolescents after first-line treatment failure. This paper describes the treatment outcomes and adverse effects of an ABT-based dual-active antiretroviral treatment regimen in a child with MDR HIV strains.

Case presentation
A 13 year-old Chinese female patient infected with MDR HIV strains showed a decrease in viral load (from 4.48 log10 to 1.73 log10) and an increase in CD4 + T cells (from 15 to 308 cells/µl) after 12 months of treatment with an ABT-based antiretroviral regimen. The child showed no relevant drug-related adverse reactions.

Conclusions
The case reported here could suggest that an ABT-based antiretroviral therapy might be beneficial and without relevant toxicity in children with MDR HIV. Infectiologists specializing in managing HIV should be prepared to manage an increasing number of children with MDR HIV. ABT might be a new treatment option for MDR HIV infection in children.
Robotic-assisted systems for the safe and reliable treatment of femoral neck fractures: retrospective cohort study
Authors: Wang Xiaofei , Zhang Yaxin , Lou Linbing , Xu Lei , Fei Wenyong , Dai Jihang , Wang Jingcheng 
Published: August 2023

Abstract
Background
Robots are being used in a wide range of surgical procedures. However, in clinical practice, the efficacy of orthopedic robotic-assisted treatment of femoral neck fractures is still poorly reported, particularly in terms of screw placement accuracy, femoral neck fracture healing rates and postoperative functional recovery. Moreover, there is a lack of comparative analysis between robot-assisted surgery and traditional surgical approaches.

Purpose
The purpose of this study was to compare the clinical outcomes of patients with femoral neck fractures treated with TiRobot-assisted hollow screw fixation with those of patients with femoral neck fractures treated with traditional surgical approaches.

Methods
This study included 112 patients with femoral neck fracture who were treated from March 2017 to October 2021 with percutaneous hollow screw internal fixation. These included 56 cases in the TiRobot-assisted surgery group and 56 cases in the standard surgery group. After at least 1 year of follow-up, the treatment outcomes of the two groups were compared, including the amount of intraoperative bleeding, the duration of intraoperative fluoroscopy, the number of guide pin positioning adjustments, the length of hospital stay, the accuracy rate of screw placement, the final Harris Hip Score, the fracture healing rate, and the rate of femoral head necrosis. Statistical analysis software was used to process and analyze the result.

Results
The TiRobot-assisted group had a statistically significant improvement over the control group in terms of intraoperative bleeding, the duration of intraoperative fluoroscopy, the number of guide pin positioning adjustments, length of hospital stay, accuracy of screw placement and incidence of femoral head necrosis (P < 0.05). There was no statistically significant difference in time to surgery, final Harris hip score and fracture healing rate (P > 0.05).

Conclusion
This study shows that TiRobot-assisted surgery has the advantages of short hospital stay, high safety, minimally invasive, high success rate of nail placement, and can reduce the amount of intraoperative radiation and the incidence of femoral head necrosis, thus achieving satisfactory clinical outcomes, and is worthy of clinical promotion.
Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives
Authors: Sroor Farid M. , Tohamy Wael M. , Zoheir Khairy M. A. , Abdelazeem Nagwa M. , Mahrous Karima F. , Ibrahim Nada S. 
Published: August 2023

AbstractThe current study involves the design and synthesis of a newly synthesized pyrrolo[2,3-d]pyrimidine derivatives to contain chlorine atoms in positions 4 and 6 and trichloromethyl group in position 2 using microwave technique as a new and robust approach for preparation of this type of pyrrolo[2,3-d]pyrimidine derivatives. The chemical structure of the synthesized pyrrolo[2,3-d]pyrimidine derivatives 3–19 was well-characterized using spectral and elemental analyses as well as single-crystal X-ray diffraction. All compounds were tested in vitro against seven selected human cancer cell lines, namely, MCF7, A549, HCT116, PC3, HePG2, PACA2 and BJ1 using MTT assay. It was found that compounds 14a, 16b and 18b were the most active toward MCF7 with IC50 (1.7, 5.7, and 3.4 μg/ml, respectively) relative to doxorubicin (Dox.) (26.1 μg/ml). Additionally, compound 17 exerted promising cytotoxic effects against HePG2 and PACA2 with IC50 (8.7 and 6.4 μg/ml, respectively) relative to Dox. (21.6 and 28.3 μg/ml, respectively). The molecular docking study confirmed our ELISA result which showed the promising binding affinities of compounds 14a and 17 against Bcl2 anti-apoptotic protein. At the gene expression level, P53, BAX, DR4 and DR5 were up-regulated, while Bcl2, Il-8, and CDK4 were down-regulated in 14a, 14b and 18b treated MCF7 cells. At the protein level, compound 14b increased the activity of Caspase 8 and BAX (18.263 and 14.25 pg/ml) relative to Dox. (3.99 and 4.92 pg/ml, respectively), while the activity of Bcl2 was greatly decreased in 14a treated MCF7 (2.4 pg/ml) compared with Dox. (14.37 pg/ml). Compounds 14a and 14b caused cell cycle arrest at the G1/S phase in MCF7. Compounds 16b and 18b induced the apoptotic death of MCF7 cells. In addition, the percentage of fragmented DNA was increased significantly in 14a treated MCF7 cells.
Genomic analyses indicate the North American Ap-ha variant of the tick-vectored bacterium Anaplasma phagocytophilum was introduced from Europe
Authors: Aardema Matthew L. 
Published: August 2023

Abstract
Background
Anaplasma phagocytophilum is a tick-vectored, obligately intracellular bacterium that infects a diversity of vertebrate hosts. In North America, the Ap-ha variant of A. phagocytophilum can cause dangerous infections in humans, whereas symptomatic human infections in Europe are rare. Conversely, the European host-generalist ecotype of A. phagocytophilum frequently causes illness in domestic ruminants while no comparable infections have been recorded from North America. Despite these differences in pathogenicity, the Ap-ha variant is closely aligned phylogenetically with the European host-generalist ecotype. Furthermore, North American populations of A. phagocytophilum are less genetically diverse than those in Europe. Taken together, these observations suggest that the North American Ap-ha variant may represent an introduced population of this bacterium.

Methods
Data from publicly available whole genomes of A. phagocytophilum were used to compare phylogeographic patterns and the extent of genetic divergence between the North American Ap-ha variant and the European host-generalist ecotype.

Results
The results confirm that North American Ap-ha samples are phylogenetically nested within the diversity of the European host-generalist ecotype, and that Ap-ha likely radiated within the last 100 years. As expected, the Ap-ha variant also exhibited relatively low genetic diversity levels compared to the European host-generalist ecotype. Finally, North American Ap-ha harbored significantly more derived alleles than the European host-generalist A. phagocytophilum population.

Conclusions
Collectively, these results support the hypothesis that the Ap-ha variant was recently introduced to North America from Europe and underwent a strong genetic bottleneck during this process (i.e. a ‘founder event’). Adaptation to novel vectors may have also played a role in shaping genetic diversity and divergence patterns in these pathogenic bacteria. These findings have implications for future studies aimed at understanding evolutionary patterns and pathogenicity variation within A. phagocytophilum.

Graphical Abstract
Ulam stability of first-order nonlinear impulsive dynamic equations
Authors: Scindia Pallavi , Tikare Sanket , El-Deeb Ahmed A. 
Published: August 2023

AbstractThis paper is devoted to the investigation of Ulam stability of first-order nonlinear impulsive dynamic equations on finite-time scale intervals. Our main objective is to formulate sufficient conditions under which the class of first-order nonlinear impulsive dynamic equations on time scales we consider exhibits Ulam stability. Our methods rely on the extended integral inequality on time scales for piecewise-continuous functions. We provide an example to support the validity of the results obtained.
Positive solutions for a class of fractional differential equations with infinite-point boundary conditions on infinite intervals
Authors: Cui Ziyue , Zhou Zongfu 
Published: August 2023

AbstractIn this paper, the existence of the multiple positive solutions for a class of higher-order fractional differential equations on infinite intervals with infinite-point boundary value conditions is mainly studied. First, we construct the Green function and analyze its properties, and then by using the Leggett–Williams fixed point theorem, some new results on the existence of positive solutions for the boundary value problem are obtained. Finally, we illustrate the application of our conclusion by an example.
High-resolution shallow crustal shear wave velocity structure of Anyuan mining area and its adjacent region in Jiangxi Province, China
Authors: Gong Meng , Lv Jian , Zhang Xingmian , Zheng Yong , Chen Hao , Dong Jun , Zha Xiaohui , Li Zheng , Sheng Shuzhong , Wang Tongli 
Published: August 2023

AbstractHigh-resolution seismic image is critically important for mining minerals. In this study, we collected seismic data from a local dense seismic array consisting of 154 stations around the Anyuan mining area and its adjacent region of Pingxiang City, Jiangxi Province in South China, and applied the ambient noise tomography (ANT) method to image the shear wave velocity structure in the study area. Shallow crustal velocities at depths less than 3.3 km were determined by direct inversion of Rayleigh wave group velocity dispersion curves at the period range of 0.5–5.0 s. Overall, the S-wave velocity structure has a tight correlation with surface geological and tectonic features in the study area. The shear wave velocity structure in the shallow crust of the Anyuan Mine and its adjacent areas displayed distinct low-velocity anomalies, which can be attributed to the depression of sedimentary structures and coal mining activities in the Pingxiang-Leping region. The zones surrounding the Anyuan fault (AYF) and Wangkeng fault (WKF) zones exhibited low-velocity anomalies from the ground surface to ~ 3.3 km underground. And the low-velocity anomalies at depths less than 1.2 km could be related to the sedimentary environment of coal mine and the coal mining activities, while the low-velocity anomalies at depths below 1.2 km are caused by the presence of fracture medium, oil and gas in the fault zone. The shear wave velocity changes sharply across the AYF, and the characteristics of the velocity change interface indicate that the AYF is inclined toward the northwest, with its extension reaching depths of approximately 3 km underground.
Graphical Abstract
Relationship between piglets’ survivability and farrowing kinetics in hyper-prolific sows
Authors: Schoos Alexandra , Muro Bruno Bracco Donatelli , Carnevale Rafaella Fernandes , Chantziaras Ilias , Biebaut Evelien , Janssens Geert Paul Jules , Maes Dominiek 
Published: August 2023

AbstractBackgroundProlonged farrowing and more piglets born with low birth weight are undesirable consequences of genetic selection for increased litter size. The objective of the present observational study was to evaluate the relationship between piglets’ survivability and farrowing kinetics in hyperprolific sows. A total of 58 sows of different parities and 1190 piglets were included. The entire farrowing process was monitored and the following parameters were recorded: inter-piglet birth interval, birth order, total born, live born, dead born, and mummified piglets, obstetric intervention, weight at birth and 24h, colostrum yield and intake.ResultsThe sows included in this study had on average 20.6 ± 0.6 total piglets born, of which 16.4 ± 0.6 were live born, 3.3 ± 0.4 were stillborn and 0.9 ± 0.2 were mummified piglets. The average farrowing duration and average birth interval were 411.3 ± 31.6 and 20.6 ± 1.7 min, respectively. Farrowing duration was positively associated (p < 0.05) with parity, number of stillborn and mummified piglets. Piglet mortality 24h after birth was negatively affected (p < 0.01) by birth weight and positively affected (p < 0.01) by cumulative birth interval. The last tercile of piglets born (birth order ≥ 17) had the highest (p < 0.01) inter-piglet birth interval (IPBI) (43.4 ± 4.17 min) compared to piglets born in the first (birth order between 2 and 7) (26.5 ± 3.8 min) and second (birth order between 8 and 16) terciles (21.9 ± 3.8 min). Cumulative birth interval, birth weight, occurrence of stillborn piglets and manual intervention were positively associated (p < 0.05) with IPBI. Piglet birth weight was also positively associated (p < 0.01) to individual colostrum intake. Piglets ingesting more colostrum had lower (p < 0.01) mortality from 24h after birth until weaning. Sow’s parity and cumulative birth interval were positively associated with the presence of stillborn piglets (p = 0.02 andp < 0.01, respectively).ConclusionReducing farrowing duration may be crucial to decrease stillbirth rate and neonatal mortality in hyperprolific sows. Moreover, special care must be provided to the lighter piglets within a litter to increase their colostrum intake and minimize piglet’s mortality throughout lactation.
Sebaceous carcinoma of nasal ala: a case report
Authors: Chakravarti Arunabha , Negi Prerna , Singh Parvendra , Sam Sneha Mary , Agarwal Kiran 
Published: August 2023

Abstract
Background
Sebaceous carcinoma is an uncommon non-melanoma skin cancer. Extraocular sites are extremely rare, with only a few cases reported in the medical literature. This article reviews the diagnostic challenges and treatment of a case of sebaceous carcinoma of nasal ala.

Case presentation
A 75-year-old female presented with a slow-growing right nasal alar mass for the last 1.5 years. It was nodular in appearance and covered with crusts and concretions. An incisional biopsy confirmed the diagnosis of sebaceous carcinoma. The patient underwent a wide local excision of the mass followed by nasolabial flap reconstruction.

Conclusions
Sebaceous Carcinoma should be included in the differential diagnosis of an elderly patient with nasal growth to avoid delaying treatment.
Subclinical cardiac dysfunction may impact on fluid and vasopressor administration during early resuscitation of septic shock
Authors: Murgolo Francesco , Mussi Rossella di , Messina Antonio , Pisani Luigi , Dalfino Lidia , Civita Antonio , Stufano Monica , Gianluca Altamura , Staffieri Francesco , Bartolomeo Nicola , Spadaro Savino , Brienza Nicola , Grasso Salvatore 
Published: August 2023

Abstract
Background
According to the Surviving Sepsis Campaign (SSC) fluids and vasopressors are the mainstays of early resuscitation of septic shock while inotropes are indicated in case of tissue hypoperfusion refractory to fluids and vasopressors, suggesting severe cardiac dysfunction. However, septic cardiac disfunction encompasses a large spectrum of severities and may remain “subclinical” during early resuscitation. We hypothesized that “subclinical” cardiac dysfunction may nevertheless influence fluid and vasopressor administration during early resuscitation. We retrospectively reviewed prospectically collected data on fluids and vasoconstrictors administered outside the ICU in patients with septic shock resuscitated according to the SSC guidelines that had reached hemodynamic stability without the use of inotropes. All the patients were submitted to transpulmonary thermodilution (TPTD) hemodynamic monitoring at ICU entry. Subclinical cardiac dysfunction was defined as a TPTD-derived cardiac function index (CFI) ≤ 4.5 min−1.

Results
At ICU admission, subclinical cardiac dysfunction was present in 17/40 patients (42%; CFI 3.6 ± 0.7 min−1 vs 6.6 ± 1.9 min−1; p < 0.01). Compared with patients with normal CFI, these patients had been resuscitate with more fluids (crystalloids 57 ± 10 vs 47 ± 9 ml/kg PBW; p < 0.01) and vasopressors (norepinephrine 0.65 ± 0.25 vs 0.43 ± 0.29 mcg/kg/min; p < 0.05). At ICU admission these patients had lower cardiac index (2.2 ± 0.6 vs 3.6 ± 0.9 L/min/m2, p < 0.01) and higher systemic vascular resistances (2721 ± 860 vs 1532 ± 480 dyn*s*cm−5/m2, p < 0.01).

Conclusions
In patients with septic shock resuscitated according to the SSC, we found that subclinical cardiac dysfunction may influence the approach to fluids and vasopressor administration during early resuscitation. Our data support the implementation of early, bedside assessment of cardiac function during early resuscitation of septic shock.
Room Temperature Anionic Episulfide Resin Adhesive UV-curable by a Thiol Initiator and Photobase Generator
Authors: Aoki Daisuke , Gu Chen , Suzuki Mayu , Kawamura Yoshinori , Arimitsu Koji 
Published: August 2023

Abstract
To address the challenges associated with room temperature curing of UV-curable epoxy adhesives, we present room temperature anionic UV-curable episulfide adhesives. The episulfide adhesives incorporate a thiol initiator and photobase generators (PBGs), composed of xanthone and phosphazene superbases. Lap shear adhesion tests demonstrated that the thiol initiator significantly enhances the lap shear strength of episulfide resin adhesives, reaching a maximum of 13 MPa. Moreover, FT-IR studies confirmed that thiol initiators accelerate the curing reaction of episulfides at room temperature.
Concorrência pública - Licitação - Limites de discricionariedade no julgamento das proprostas
Authors: Mello Celso Antonio Bandeira de 
Published: August 2023

A teoria do desvio de poder e dos motivos determinantes éque tem servido eficazmente para o reconhecimento dos limites da liberdade do administrador.- A discricionariedade é a margem de liberdade conferidapela lei ao administrador para decidir segundo um critério próprio, baseado em conveniência e oportunidade, a fim de compor no caso específico a concreta vontade legal.
Problemas atuais da desapropriação
Authors: Tácito Caio 
Published: August 2023

Evolução histórica. Desapropriação e inflação. Desapropriação de ações. Desapropriação e desvio de poder. Desapropriação e urbanismo. Desapropriação e reforma agrária. Outras situações relevantes. Conclusão.
Controle integrado do ato administrativo
Authors: Jappur José 
Published: August 2023

Estado e direito. As regras do controle no tempo e na atualidade. Os princípios de legalidade e de legitimidade. Moralidade administrativa.A moral e o direito. A forma e a substância. O exame do mérito. Preconceito do passado e novas linhas do presente. Moralidadecomo legitimidade de fins e motivos determinantes. O controle da "livre discrição". Auditoria das contas como instrumento do controle integrado. Tomada de contas. Seu conteúdo múltiplo. Missão moderna dos Tribunais de Contas.
Os tributos no quadro do direito
Authors: Silva José Afonso da 
Published: August 2023

Sumário: I. O ESTADO E A TRIBUTAÇÃO. 1. As atividades estatais e seus custos. 2. O poder do Estado para exigir contribuições. 3. Conceito jurídico de tributo. lI. LEGALIDADE DO FENOMENO TRIBUT ARIO. 4. Os tributos como objeto do direito. 5. O princípio da legalidade tributária. 6. O Estado legislador e o Estado fisco. 7. Relação jurídica tributária. 8. Direito tributário e sua natureza. III. RELAÇÕES DO DIREITO TRIBUT ARIO COM ASDEMAIS DISCIPLINAS JURIDICAS. 9. Autonomia do direito tributário. 10. Relações do direito tributário com outros ramos do direito público. 11. Relações do direito tributário com os ramos do direito privado. 12. Normas do direito positivo sobre as relações do direito tributário com outras disciplinas jurídicas. IV. CONCLUSÕES.
Do controle de constitucionalidade das desapropriações
Authors: Nogueira Rubem R. 
Published: August 2023

O Decreto-lei rf! 3 365 de 1941. Antecedentes doutrinários ejurisprudenciais. Questão constitucional. Opinião de Rui Barbosa.Evolução doutrinária. Limites ao processo judicial. Açãodireta contra o ato expropriat6rio. Art. 153, § 4<?, da Constituição.Conclusões."Questões constitucionais são, ante a Constituição brasileira, a questãode necessidade pública e a questão de utilidade pública, nas desapropriações."Rui Barbosa (Supremo Tribunal Federal. Conflito de Jurisdição nQ 481, 1921. In: Comentários à Constituição Federal Brasileira, coligidos e ordenados por Homero Pires, v. 5, São Paulo, 1934. p. 427)."Na verdade, qualquer discussão limitada ao valor da coisa desapropriada,não entrando no exame da juridicidade da desapropriação,conflita-se com a disposição constitucional na qual assenta o direitode propriedade individual." Manoel de Oliveira Franco Sobrinho(Desapropriação na doutrina - no direito brasileiro - na legislalaçãocomparada. São Paulo, 1973. nQ 113).
Tribunal de Contas do Município de São Paulo - Controle e fiscalização das empresas municipais
Authors: Barreto Filho Oscar 
Published: August 2023

- A forma jurídica das empresas municipais.- Controle e fiscalização dos órgãos da administração indireta.- Legitimidade do controle externo de empresas públicas e mistas.- Limites e forma de controle externo das empresas públicas e mistas (direito comparado).- O estado do problema na doutrina nacional.- Respostas às questões da consulta.
Vias de fato no serviço público de energia elétrica e uso ilícito de eletricidade
Authors: Alvares Walter T. 
Published: August 2023

1. Objetivo temático na relação básica. 2. A concessão e o serviçopúblico concedido de energia elétrica. 3. O sujeito intermediário doserviço público concedido. 4. Titularidade do usuário ao serviço. 5. Oquadro geral da descontinuidade do serviço. 6. A força do ato administrativo e a proteção judicial do administrado. 7. Via de fato praticada pelo usuário. 8. Inidoneidade do consumidor. 9. Uso ilícitode corrente elétrica. 10. Conclusão.