bluuebunny/crossref_metadata_2025_split huggingface dataset:
With a little help from my friends: adopting a P-E fit perspective in understanding the value of organizational learning climate for sustainable employability
Authors: Vuuren Tinka Van , Van der Heijden Beatrice I. J. M. , Semeijn Judith H. 
Published: April 2023

PurposeThe objective of our study was to investigate how organizational learning climate (measured as developmental opportunities and team support for learning), career commitment, and age are related to employees’ self-perceived employability, vitality and work ability (e.g., their sustainable employability). Our study adopted a P-E fit perspective building upon the notion that sustainable employability is a function of both the person (P) and the environment (E) and tests a three-way interaction between organizational learning climate, career commitment, and age.DesignIn total, 211 members of the support staff of a Dutch university completed a survey. Hierarchical stepwise regression analysis was used to analyze the data.FindingsOnly one of the two dimensions of organizational learning climate that we measured, namely the developmental opportunities, appeared to be associated with all indicators of sustainable employability. Career commitment only had a direct positive relationship with vitality. Age was negatively related to self-perceived employability and to work ability, but not to vitality. The relationship between developmental opportunities and vitality was negatively influenced by career commitment (a negative two-way interaction effect), while a positive three-way interaction effect was found between career commitment, age, and development opportunities, and with self-perceived employability as the outcome.Theoretical and practical implicationsOur findings confirmed the relevance of adopting a P-E fit perspective on sustainable employability, and of considering the possible role of age in this. It requires more detailed analyses in future research to unravel the role of age in the shared responsibility for sustainable employability. In practice, the results of our study imply that organizations should provide all employees with a working context that facilitates learning, however, with a special focus on older employees, for whom it is a particular challenge to protect their sustainable employability, possibly due to age-related stereotyping.OriginalityOur study adopted a P-E fit perspective on sustainable employability and examined the association between organizational learning climate and all three components of sustainable employability: self-perceived employability, vitality and work ability. Moreover, it investigated whether and how the employee’s career commitment and age influence this relationship.
Network analysis of the relationships between problematic smartphone use and anxiety, and depression in a sample of Chinese college students
Authors: Guo Zhihua , Yang Tianqi , Qiu Rui , Qiu Huake , Ren Lei , Liu Xufeng , Han Zheyi , Zhu Xia 
Published: April 2023

BackgroundProblematic smartphone use (PSU) is associated with both anxiety and depression. However, the relationships between components of PSU and symptoms of anxiety or depression have not been investigated. Hence, the aim of this study was to closely examine the relationships between PSU and anxiety and depression to identify the pathological mechanisms underpinning those relationships. A second aim was to identify important bridge nodes to identify potential targets for intervention.MethodsSymptom-level network structures of PSU and anxiety, and PSU and depression were constructed to investigate the connections between the variables and evaluate the bridge expected influence (BEI) of each node. Network analysis using data from 325 Chinese healthy college students was performed.ResultsFive strongest edges appeared within the communities in both the PSU-anxiety and PSU-depression networks. The “Withdrawal” component had more connections with symptoms of anxiety or depression than any other PSU node. In particular, the edges between “Withdrawal” and “Restlessness” and between “Withdrawal” and “Concentration difficulties” were the strongest cross-community edges in the PSU-anxiety network and PSU-depression network, respectively. Furthermore, “Withdrawal” had the highest BEI in the PSU community in both networks.ConclusionsThese findings provide preliminary evidence of the pathological pathways linking PSU with anxiety and depression, with “Withdrawal” linking PSU with both anxiety and depression. Hence, “Withdrawal” may be a potential target for preventing and intervening in cases of anxiety or depression.
Serum metabolomics analysis in patients with alcohol dependence
Authors: Zhang Yanjie , Sun Yajun , Miao Qin , Guo Shilong , Wang Qi , Shi Tianyuan , Guo Xinsheng , Liu Shuai , Cheng Guiding , Wang Chuansheng , Zhang Ruiling 
Published: April 2023

ObjectiveAlcohol dependence (AD) is a chronic recurrent mental disease caused by long-term drinking. It is one of the most prevalent public health problems. However, AD diagnosis lacks objective biomarkers. This study was aimed to shed some light on potential biomarkers of AD patients by investigating the serum metabolomics profiles of AD patients and the controls.MethodsLiquid chromatography-mass spectrometry (LC–MS) was used to detect the serum metabolites of 29 AD patients (AD) and 28 controls. Six samples were set aside as the validation set (Control: n = 3; AD group: n = 3), and the remaining were used as the training set (Control: n = 26; AD group: n = 25). Principal component analysis (PCA) and partial least squares discriminant analysis (PCA-DA) were performed to analyze the training set samples. The metabolic pathways were analyzed using the MetPA database. The signal pathways with pathway impact &gt;0.2, value of p &lt;0.05, and FDR &lt; 0.05 were selected. From the screened pathways, the metabolites whose levels changed by at least 3-fold were screened. The metabolites with no numerical overlap in their concentrations in the AD and the control groups were screened out and verified with the validation set.ResultsThe serum metabolomic profiles of the control and the AD groups were significantly different. We identified six significantly altered metabolic signal pathways, including protein digestion and absorption; alanine, aspartate, and glutamate metabolism; arginine biosynthesis; linoleic acid metabolism; butanoate metabolism; and GABAergic synapse. In these six signal pathways, the levels of 28 metabolites were found to be significantly altered. Of these, the alterations of 11 metabolites changed by at least 3-fold compared to the control group. Of these 11 metabolites, those with no numerical overlap in their concentrations between the AD and the control groups were GABA, 4-hydroxybutanoic acid, L-glutamic acid, citric acid and L-glutamine.ConclusionThe metabolite profile of the AD group was significantly different from that of the control group. GABA, 4-hydroxybutanoic acid, L-glutamic acid, citric acid, and L-glutamine could be used as potential diagnostic markers for AD.
Preliminary findings on the effect of childhood trauma on the functional connectivity of the anterior cingulate cortex subregions in major depressive disorder
Authors: Rong Bei , Gao Guoqing , Sun Limin , Zhou Mingzhe , Zhao Haomian , Huang Junhua , Wang Hanling , Xiao Ling , Wang Gaohua 
Published: April 2023

ObjectivesChildhood trauma (CT) is a known risk factor for major depressive disorder (MDD), but the mechanisms linking CT and MDD remain unknown. The purpose of this study was to examine the influence of CT and depression diagnosis on the subregions of the anterior cingulate cortex (ACC) in MDD patients.MethodsThe functional connectivity (FC) of ACC subregions was evaluated in 60 first-episode, drug-naïve MDD patients (40 with moderate-to-severe and 20 with no or low CT), and 78 healthy controls (HC) (19 with moderate-to-severe and 59 with no or low CT). The correlations between the anomalous FC of ACC subregions and the severity of depressive symptoms and CT were investigated.ResultsIndividuals with moderate-to severe CT exhibited increased FC between the caudal ACC and the middle frontal gyrus (MFG) than individuals with no or low CT, regardless of MDD diagnosis. MDD patients showed lower FC between the dorsal ACC and the superior frontal gyrus (SFG) and MFG. They also showed lower FC between the subgenual/perigenual ACC and the middle temporal gyrus (MTG) and angular gyrus (ANG) than the HCs, regardless of CT severity. The FC between the left caudal ACC and the left MFG mediated the correlation between the Childhood Trauma Questionnaire (CTQ) total score and HAMD-cognitive factor score in MDD patients.ConclusionFunctional changes of caudal ACC mediated the correlation between CT and MDD. These findings contribute to our understanding of the neuroimaging mechanisms of CT in MDD.
Early effects of COVID-19 on maternal and child health service disruption in Mozambique
Authors: Augusto Orvalho , Roberton Timothy , Fernandes Quinhas , Chicumbe Sérgio , Manhiça Ivan , Tembe Stélio , Wagenaar Bradley H. , Anselmi Laura , Wakefield Jon , Sherr Kenneth 
Published: April 2023

This article is part of the Research Topic ‘Health Systems Recovery in the Context of COVID-19 and Protracted Conflict'IntroductionAfter the World Health Organization declared COVID-19 a pandemic, more than 184 million cases and 4 million deaths had been recorded worldwide by July 2021. These are likely to be underestimates and do not distinguish between direct and indirect deaths resulting from disruptions in health care services. The purpose of our research was to assess the early impact of COVID-19 in 2020 and early 2021 on maternal and child healthcare service delivery at the district level in Mozambique using routine health information system data, and estimate associated excess maternal and child deaths.MethodsUsing data from Mozambique's routine health information system (SISMA, Sistema de Informação em Saúde para Monitoria e Avaliação), we conducted a time-series analysis to assess changes in nine selected indicators representing the continuum of maternal and child health care service provision in 159 districts in Mozambique. The dataset was extracted as counts of services provided from January 2017 to March 2021. Descriptive statistics were used for district comparisons, and district-specific time-series plots were produced. We used absolute differences or ratios for comparisons between observed data and modeled predictions as a measure of the magnitude of loss in service provision. Mortality estimates were performed using the Lives Saved Tool (LiST).ResultsAll maternal and child health care service indicators that we assessed demonstrated service delivery disruptions (below 10% of the expected counts), with the number of new users of family planing and malaria treatment with Coartem (number of children under five treated) experiencing the largest disruptions. Immediate losses were observed in April 2020 for all indicators, with the exception of treatment of malaria with Coartem. The number of excess deaths estimated in 2020 due to loss of health service delivery were 11,337 (12.8%) children under five, 5,705 (11.3%) neonates, and 387 (7.6%) mothers.ConclusionFindings from our study support existing research showing the negative impact of COVID-19 on maternal and child health services utilization in sub-Saharan Africa. This study offers subnational and granular estimates of service loss that can be useful for health system recovery planning. To our knowledge, it is the first study on the early impacts of COVID-19 on maternal and child health care service utilization conducted in an African Portuguese-speaking country.
COVID-19 vaccination status, side effects, and perceptions among breast cancer survivors: a cross-sectional study in China
Authors: Xu Yali , Li Linrong , Li Xiaomeng , Li Haolong , Song Yu , Liu Yongmei , Chen Chang , Zhan Haoting , Wang Zhe , Feng Xinxin , Liu Mohan , Wang Yingjiao , Liu Guanmo , Qu Yang , Li Yuechong , Li Yongzhe , Sun Qiang 
Published: April 2023

IntroductionBreast cancer is the most prevalent malignancy in patients with coronavirus disease 2019 (COVID-19). However, vaccination data of this population are limited.MethodsA cross-sectional study of COVID-19 vaccination was conducted in China. Multivariate logistic regression models were used to assess factors associated with COVID-19 vaccination status.ResultsOf 2,904 participants, 50.2% were vaccinated with acceptable side effects. Most of the participants received inactivated virus vaccines. The most common reason for vaccination was “fear of infection” (56.2%) and “workplace/government requirement” (33.1%). While the most common reason for nonvaccination was “worry that vaccines cause breast cancer progression or interfere with treatment” (72.9%) and “have concerns about side effects or safety” (39.6%). Patients who were employed (odds ratio, OR = 1.783, p = 0.015), had stage I disease at diagnosis (OR = 2.008, p = 0.019), thought vaccines could provide protection (OR = 1.774, p = 0.007), thought COVID-19 vaccines were safe, very safe, not safe, and very unsafe (OR = 2.074, p &lt; 0.001; OR = 4.251, p &lt; 0.001; OR = 2.075, p = 0.011; OR = 5.609, p = 0.003, respectively) were more likely to receive vaccination. Patients who were 1–3 years, 3–5 years, and more than 5 years after surgery (OR = 0.277, p &lt; 0.001; OR = 0.277, p &lt; 0.001, OR = 0.282, p &lt; 0.001, respectively), had a history of food or drug allergies (OR = 0.579, p = 0.001), had recently undergone endocrine therapy (OR = 0.531, p &lt; 0.001) were less likely to receive vaccination.ConclusionCOVID-19 vaccination gap exists in breast cancer survivors, which could be filled by raising awareness and increasing confidence in vaccine safety during cancer treatment, particularly for the unemployed individuals.
Validity of a new sport-specific endurance test in artistic gymnastics
Authors: Mkaouer Bessem , Amara Samiha , Bouguezzi Raja , Ben Abderrahmen Abderraouf , Chaabene Helmi 
Published: April 2023

IntroductionGeneral and particularly sport-specific testing is an integral aspect of performance optimization in artistic gymnastics. In artistic gymnastics, however, only non-specific field tests have been used to assess endurance performance (e.g., Multistage Shuttle Run Test; Cooper's Test).MethodsThis study aimed to examine the validity of a new sport-specific endurance test in artistic gymnastics. Fourteen elite-level gymnasts (i.e., eight males and six females) participated in this study. The newly developed artistic gymnastics-specific endurance test (AGSET) was conducted on two different occasions seven days apart to determine its reliability. To assess the concurrent validity of AGSET, participants performed the multistage shuttle run test (MSRT). Maximum oxygen uptake (VO2max) and respiratory exchange ratio (RER) were directly assessed using a portable gas analyzer system during both protocols. Additionally, the total time maintained (TTM) during the AGSET, maximum heart rate (HRmax), maximal aerobic speed (MAS), and blood lactate concentration (BLa) during the two protocols were collected.ResultsThe main findings indicated that all variables derived from the AGSET (i.e., VO2max, MAS, HRmax, BLa, and RER) displayed very good relative (all intraclass correlation coefficients [ICC] &gt; 0.90) and absolute (all typical errors of measurement [TEM] &lt; 5%) reliability. Further, results showed that the ability of the AGSET to detect small changes in VO2max, MAS, BLa, and RER was good (smallest worthwhile change [SWC0.2] &gt; TEM), except HRmax (SWC0.2 &lt; TEM). Additionally, results showed a nearly perfect association between the VO2max values derived from the AGSET and MSRT (r = 0.985; coefficient of determination [R²] = 97%) with no statistically significant differences (p&gt;0.05). The mean (bias) ± 95% limits of agreement between the two protocols were 0.28 ± 0.55 mlminkg-1.DiscussionAGSET seems to present very good reliability and concurrent validity for assessing endurance performance in elite artistic gymnastics. In addition, the newly developed protocol presents a good ability to detect small changes in performance.
Rivaroxaban vs. warfarin for the treatment and prevention of venous thromboembolism: A meta-analysis
Authors: Liu Zhuang , Song Dan , Wang Liang , Wang Changfeng , Zhou Jie , Sun Jiali , Guo Lei 
Published: April 2023

BackgroundAnticoagulant treatment is used to treat and prevent venous thromboembolism (VTE). However, the relative effectiveness of newer anticoagulants vs. warfarin has not been appraised.ObjectiveThe aim was to evaluate the safety and efficacy of rivaroxaban for VTE in comparison to warfarin.Materials and methodsFrom January 2000 until October 2021, all related studies were collected by EMBASE, the Cochrane Library, PubMed and Web of Scienceand. During the review process, two reviewers independently analyzed the included studies, including quality evaluation, screening and data extraction. We focused on VTE events as our primary outcomes.ResultsIn total, 20 trials were retrieved. These studies involved 230,320 patients, of which 74,018 received rivaroxaban and 156,302 received warfarin. Compared with warfarin, the incidence of VTE in rivaroxaban is significantly lower (risk ratio (RR) 0.71, 95% confidence interval (CI) [0.61, 0.84]; P &lt; 0.0001, random effect model), and signiﬁcantly reduced major [RR: 0.84, 95% CI (0.77, 0.91); P &lt; 0.0001, fixed effect model] and nonmajor [RR: 0.55, 95% CI (0.41, 0.74); P &lt; 0.0001, fixed effect model] bleeding. No signiﬁcant differences in all-cause mortality between the two groups [RR: 0.68, 95% CI (0.45, 1.02); P = 0.06, fixed effect model].ConclusionRivaroxaban significantly reduced the incidence of VTE compared to warfarin in this meta-analysis. In order to verify these findings, larger sample sizes are required in well-designed studies.
Long-term effect of transurethral partial cystectomy with a 2-micrometer continuous-wave laser for non-muscle-invasive bladder cancer
Authors: Lu Yongliang , Jiang Sinan , Yin Xiaotao , Guo Jiaxiang , Zhu Xiaoying , Ma Han , Zhang Guohui , Yu Hualiang , Xiao Yi , Yang Yong 
Published: April 2023

PurposeWe have reported the efficacy and safety of 2-micrometer continuous-wave laser cystectomy of non-muscle invasive bladder tumor (NMIBC) (J Urol. 2009;182:66–9). In this study, we evaluated the long-term outcomes of patients with NMIBC who underwent transurethral partial cystectomy with a 2-micrometer continuous-wave laser, and explored the risk factors for tumor recurrence.MethodsThis was a retrospective study of patients with NMIBC planned to undergo transurethral partial cystectomy with a 2-micrometer continuous-wave laser at the Fourth Medical Center of the PLA General Hospital between January 2012 and December 2014. The primary outcome was bladder cancer recurrence.ResultsA total of 75 patients were enrolled. Sixty-two (82.7%) were male. The patients were 59.8 ± 12.9 years of age. The mean operation time was 38.7 ± 20.4 min. No Clavien grade &gt;2 complications occurred. The duration of catheter indwelling was 3.6 ± 1.8 days. The hospital stay was 6.0 ± 2.3 days. The median follow-up was 80 months. A total of 17 patients had a recurrence during follow-up, and the recurrence-free survival (RFS) rate was 77.3%. In the multivariable analysis, the tumor risk group were independently associated with the recurrence of NMIBC (p = 0.026).ConclusionsAfter TURBT with a 2-micrometer continuous-wave laser, RFS was 77.3% at the median follow-up of 80 months. All complications were mild. Only tumor risk group was independently associated with the recurrence of NMIBC.
Performance of two clinical fluorescence imaging systems with different targeted and non-targeted near-infrared fluorophores: a cadaveric explorative study
Authors: Chiti Lavinia E. , Husi Benjamin , Park Brian , Beer Patricia , D'Orchymont Faustine , Holland Jason P. , Nolff Mirja C. 
Published: April 2023

IntroductionNear-infrared (NIR) fluorescence-guided surgery is increasingly utilized in humans and pets. As clinical imaging systems are optimized for Indocyanine green (ICG) detection, the usage of targeted dyes necessitates the validation of these systems for each dye. We investigated the impact of skin pigmentation and tissue overlay on the sensitivity of two NIR cameras (IC-FlowTM, VisionsenseTM VS3 Iridum) for the detection of non-targeted (ICG, IRDye800) and targeted (AngiostampTM, FAP-Cyan) NIR fluorophores in an ex vivo big animal model.MethodsWe quantitatively measured the limit of detection (LOD) and signal-to-background ratio (SBR) and implemented a semi-quantitative visual score to account for subjective interpretation of images by the surgeon.ResultsVisionsenseTM VS3 Iridum outperformed IC-FlowTM in terms of LOD and SBR for the detection of all dyes except FAP-Cyan. Median SBR was negatively affected by skin pigmentation and tissue overlay with both camera systems. Level of agreement between quantitative and semi-quantitative visual score and interobserver agreement were better with VisionsenseTM VS3 Iridum.ConclusionThe overlay of different tissue types and skin pigmentation may negatively affect the ability of the two tested camera systems to identify nanomolar concentrations of targeted-fluorescent dyes and should be considered when planning surgical applications.
Welfare implications on management strategies for rearing dairy calves: A systematic review. Part 2 – Social management
Authors: Carulla Patricia , Villagrá Arantxa , Estellés Fernando , Blanco-Penedo Isabel 
Published: April 2023

IntroductionRaising a healthy calf up to puberty is essential for optimal farm performance. It is therefore, it is necessary to promote animal welfare from the three spheres during this short period. Social management has been postulated as essential in lowering stress and consequently improving calf welfare during this period. Only the health sphere has been studied for a long time, but more recent studies have recently promoted positive experiences and emotional states from affective states or cognitive judgment and natural living spheres. A systematic review of different management strategies in rearing dairy calves according to the three spheres of animal welfare has been conducted using an electronic search strategy.MethodsThe analysis and extraction of information from the studies were performed according to a protocol. From 1,783 publications screened, only 351 met the inclusion criteria.ResultsThe publications identified in the search can be divided into two main groups, feeding and social management, based on the main topic of the publication. This review provides an overview of social management, understood as the calf’s interaction with others around it.DiscussionPrimary social management issues that emerged were social housing with congeners, separation from the mother and human-animal interaction, distributed in the three broad spheres of animal welfare. The review highlights unresolved questions about how social management practices affect the three spheres of animal welfare at this life stage and the need to standardize good socialization practices for this stage. In conclusion, all the information shows that social housing has improved animal welfare from affective states, cognitive judgment, and natural living spheres. However, gaps in research were identified in relation to the optimal time to separate the calf from the mother, the optimal time to group with conspecifics after birth and group size. Further research on positive welfare through socialization are needed.