bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Personalized Oral Cancer Survival Calculator to Estimate Risk of Death From Both Oral Cancer and Other Causes
Authors: Davies Louise , Hankey Benjamin F. , Wang Zhuoqiao , Zou Zhaohui , Scott Susan , Lee Minjung , Cho Hyunsoon , Feuer Eric J. 
Published: July 2023

ImportanceStandard cancer prognosis models typically do not include much specificity in characterizing competing illnesses or general health status when providing prognosis estimates, limiting their utility for individuals, who must consider their cancer in the context of their overall health. This is especially true for patients with oral cancer, who frequently have competing illnesses.ObjectiveTo describe a statistical framework and accompanying new publicly available calculator that provides personalized estimates of the probability of a patient surviving or dying from cancer or other causes, using oral cancer as the first data set.Design, Setting, and ParticipantsThe models used data from the Surveillance, Epidemiology, and End Results (SEER) 18 registry (2000 to 2011), SEER-Medicare linked files, and the National Health Interview Survey (NHIS) (1986 to 2009). Statistical methods developed to calculate natural life expectancy in the absence of the cancer, cancer-specific survival, and other-cause survival were applied to oral cancer data and internally validated with 10-fold cross-validation. Eligible participants were aged between 20 and 94 years with oral squamous cell carcinoma.ExposuresHistologically confirmed oral cancer, general health status, smoking, and selected serious comorbid conditions.Main Outcomes and MeasuresProbabilities of surviving or dying from the cancer or from other causes, and life expectancy in the absence of the cancer.ResultsA total of 22 392 patients with oral squamous cell carcinoma (13 544 male [60.5%]; 1476 Asian and Pacific Islander [6.7%]; 1792 Black [8.0%], 1589 Hispanic [7.2%], 17 300 White [78.1%]) and 402 626 NHIS interviewees were included in this calculator designed for public use for patients ages 20 to 86 years with newly diagnosed oral cancer to obtain estimates of health status–adjusted age, life expectancy in the absence of the cancer, and the probability of surviving, dying from the cancer, or dying from other causes within 1 to 10 years after diagnosis. The models in the calculator estimated that patients with oral cancer have a higher risk of death from other causes than their matched US population, and that this risk increases by stage.Conclusions and relevanceThe models developed for the calculator demonstrate that survival estimates that exclude the effects of coexisting conditions can lead to underestimates or overestimates of survival. This new calculator approach will be broadly applicable for developing future prognostic models of cancer and noncancer aspects of a person’s health in other cancers; as registries develop more linkages, available covariates will become broader, strengthening future tools.
Schottky Heterojunction Realizes In Situ Vaccine‐Like Antitumor Efficacy and Microenvironment Remodeling Upon Near‐Infrared Laser Response in Cold Tumors
Authors: Song Xueru , Zhou Xiaoyu , Pan Yunfeng , Liang Kaijie , Luo Yuting , Xie Wanrong , Lv Zhongyang , Yang Dingyi , Wang Yong , Wu X.S. , Wu Yizhang , Wei Jia 
Published: July 2023

AbstractCold tumor is one of the most refractory tumors due to its low immunogenicity and absence of T cell infiltration. The immunotherapeutic effect of near‐infrared (NIR) responsive nanomaterials on tumors is far from satisfactory. Herein, ultrasmall γ‐MnO2 nanodots are anchored on the intrinsic metallic Ti3C2(OH)2, modified with bovine serum albumin, to realize a Schottky heterojunction (labeled as TC‐MnO2@BSA), which can be utilized to reshape the cold tumor microenvironment (TME) through in situ vaccine‐like antitumor effect. The Schottky heterojunction endows TC‐MnO2@BSA with improved photothermal conversion and reactive oxygen species (ROS) generation. Excess ROS and heat lead to tumor immunogenic death (ICD) and abundant damaged double‐strain DNA releasing into TME, coordinated with TC‐MnO2@BSA‐derived Mn2+, magnifying the cGAS‐STING signaling pathway, eventually promoting antigen presentation of dendritic cells and infiltration of T cells. Such a NIR‐activated nanovaccine can achieve complete ablation of tumors while robust activating systemic antitumor immune response. Furthermore, it inhibits the growth of abscopal tumors through dramatically “heating” their cold TME. This work introduces a universal strategy to magnify the photothermal and immune adjuvant effect through the gain of Schottky heterostructure, as a novel paradigm to construct the multifunctional in situ nanovaccine.
A New Class of Donor‐π‐Acceptor Phosphonium Salt Exhibiting Intriguing Thermally Activated Delayed Fluorescence
Authors: Wei Jun‐Hua , Luo Jian‐Bin , He Zi‐Lin , Zhang Zhi‐Zhong , Kuang Dai‐Bin 
Published: July 2023

AbstractThermally activated delayed fluorescence (TADF) behaviors in metal halide perovskite and perovskite derivatives are rarely reported due to the absence of suitable TADF molecules that can serve as the A‐site cations. Herein, a series of novel donor‐π‐acceptor type of molecules are developed by adopting substituted phosphine and phosphonium as the electron donor and acceptor linked by the polarized π‐spacer. The prepared ((diphenylphosphaneyl)phenyl)diphenylphosphonium‐X (BzDPP‐X, X = counterions: Cl−, Br−, I−, NO3−, CH3COO− etc.) salts show bright emission in the visible range with TADF characteristics due to the strong intramolecular charge transfer (ICT). Benefiting from the spatially separated highest occupied molecular orbital and lowest unoccupied molecular orbital, small singlet‐triplet energy splitting (ΔEST) is obtained, facilitating the reverse intersystem crossing process. It turns out that the emission of BzDPP‐X is dependent on the counter anions, and the counterions help to stabilize the ICT state. Intriguingly, the emission can be tuned by integrating metal‐halide units into the above phosphonium salt. Remarkably, the zinc‐based halide exhibits a higher photoluminescence quantum yield (36.2%) than the pure benzyl(2‐(diphenylphosphaneyl)phenyl)diphenylphosphonium bromide (26.9%). This work exemplifies an easy design concept and a facile synthetic method toward ionic luminescent materials.
High‐Throughput Fabrication of Curved Plasmonic Metasurfaces for Switchable Beam Focusing and Thermal Infrared Cloaking
Authors: Gong Jintao , Xiong Lingxing , Pu Mingbo , Wen Yifeng , Cai Jixiang , Feng Xingdong , Pan Rui , He Qiong , Guo Yinghui , Chi Nan , Ma Xiaoliang , Li Xiong , Luo Xiangang 
Published: July 2023

AbstractConsiderable effort is devoted to research on reconfigurable beam focusing and optical cloaking in the basis of metamaterials/metasurfaces. However, it remains a great challenge to achieve multifunctional wavefront control on curved platforms, especially in the reflective case, which is of paramount importance in the emerging fields of active optics and stealth research. This study proposes a novel strategy to control the versatile reflective structured wavefront on a conformal platform by curving a flexible metasurface. This metasurface is fabricated in a high‐throughput manner by using ultra‐violet nano‐imprinting lithography (UV‐NIL), and its efficacy is verified through consistent simulated and experimental results. The conformal metasurface is designed to realize multifunctional performance by employing all‐metallic plasmonic structures based on the Pancharatnam‐Berry (PB) phase. A general theoretical scheme is also proposed for the projection of a curved surface onto a reference plane by a judicious compensation, combining the geometrical PB phase with curvature‐induced propagation phase. Moreover, as a proof‐of‐concept, curved metasurfaces with cylindrical shapes are experimentally characterized by their multifunctionalities in generating a beam spot with a continuously tunable focal length and reflecting plane waves used for camouflage, thereby confirming the feasibility and effectiveness of the proposed strategy.
Flexible PANI/Lotus Stemmed Fiber Sensor for Bifunctional Sensing of Physical and Chemical Stimuli
Authors: Li Hongxing , Xu Li , Cheng Kaige , Ma Xu , Xiao Wei , Qiang Qinping , Lang Tianchun , Cao Shixiu , Peng Lingling , Zhao Yaru , Liu Bitao 
Published: July 2023

AbstractIn recent times, high‐performance flexible sensors that can be fabricated environmentally friendly and low‐costly have received considerable attention owing to their potential applications in wearable health monitoring. The combination of biocompatibility, degradability, and recyclability between the substrate and sensor layer remains a challenge. Here, a highly sensitive multifunctional sensor is developed using a polyaniline (PANI)‐coated lotus stem fabric (PANI/LSF) for body physical and chemical stimuli in a simple way. The lotus stem fabric has excellent breathability, skin compatibility, and lightweight as a flexible substrate. Its high sensitivity at low pressure is experimentally verified, which can reach 0.3 kPa−1 in the 0–1.5 kPa range. In addition, the sensor has low detection limitation and good linearity of response to water molecules and short response and recovery times for water in N2 or normal atmosphere at the range of 3.7–70.5% relative humidity (RH) and 19.6–66.8% RH, respectively. This can be successfully used in the recognition of various breathing behaviors. Therefore, the study has developed a breathable and skin‐friendly bifunctional sensor based on PANI and natural fabrics, which has great potential for application in human health care.
Using social media‐based drama therapy and family counselling to treat symptoms of postpartum depression among women
Authors: Onogwu Elizabeth Odachi , Alidu Ojonugbede Samuel , Anibueze Anselm U. , Okwuowulu Charles , Ekwueme Obiorah , Erojikwe Ikechukwu , Gever Verlumun Celestine 
Published: July 2023

AbstractThis study examines the impact of social media‐based drama therapy and family counselling in reducing symptoms of postpartum depression (PPD) in women aged 18–34. The researchers used a quasi‐experimental design and randomly assigned the participants (n = 303) to the control, drama therapy, and family counselling groups. The key findings of the study are as follows. First, at baseline, women not only showed more symptoms of PPD than their male counterparts, but men also reached the PPD threshold of 12/13. Second, the difference between women and men regarding their PPD scores achieved statistical significance (p = 0.004). However, during the post‐intervention assessment, men who received drama therapy intervention reported a significant drop in their PPD below the threshold of 12/13. Only women whose spouses received family counselling on spousal support reported a significant drop in their PPD. However, those whose partners did not receive family counselling on spousal support still reported PPD scores within the threshold. In both instances, women in the control group still had high PPD scores. Finally, during the 6‐month follow‐up assessment, even men in the control group did not have significant symptoms of PPD as their scores dropped below the threshold. On the contrary, women in the control group still had high PPD, indicating that PPD lasted more in women than in men. Also, women whose husbands received family counselling on spousal support reported PPD scores below the threshold. However, women whose husbands did not receive spousal counselling still had PPD scores at the threshold, even though their scores marginally dropped.
A case of phantom pain and stump pain that was effectively controlled by ultrasound‐guided ulnar and median peripheral nerve blocks
Authors: Sekiguchi Shunya , Ishida Yusuke , Fujita Yosuke , Tomino Mikiko , Ohseto Kiyoshige 
Published: July 2023

AbstractPhantom limb pain and stump pain are often intractable, and their incidences are relatively high. We report a case of a patient with phantom limb and stump pain of the finger, who was successfully treated by peripheral nerve blocks. The patient was a male truck driver in his fifties, who had his left annular finger amputated in an accident 2 years previously. Owing to poor pain control at the stump of his finger, he was referred to our department. The initial examination revealed pain about numerical rating scale (NRS) 6/10 in the left annular finger transection as well as allodynia. Although some pain relief had been observed with postoperative medication, he still had persistent resting pain of about NRS 4/10. Therefore, blocks of the ulnar nerve and median nerve were performed. After the blocks were performed, the pain improved to NRS 1 to 2/10, and pain upon movement also almost disappeared. Peripheral nerve blocks can be a useful treatment modality for phantom limb pain and stump pain in the fingers, as in this case.
Anabolic‐androgenic anabolic steroids as a probable risk factor for hepatoblastoma in infants
Authors: Malekiantaghi Armen , Shabani‐Mirzaee Hosein , Ehsani MohammadAli , Eftekhari Kambiz 
Published: July 2023

Key Clinical MessageThe etiology of hepatoblastoma (HB) is still unknown; several risk factors have been identified. The only risk factor for the development of HB in presented case was the child's father using anabolic androgenic steroids. It may be a risk factor for developing HB in their children.AbstractHB is the most common primary liver cancer in children. Its etiology is still unclear. The patient's father's use of androgenic anabolic steroids could be a risk factor for developing HB in his child. A 14‐month‐old girl was hospitalized with intermittent fever, severe abdominal distention, and anorexia. On initial examination, she was cachectic and pale. There were two hemangioma‐like skin lesions in the back. Huge hepatomegaly was found and the ultrasound showed a hepatic hemangioma. The possibility of malignancy was considered due to the severe enlargement of the liver and the increased levels of the alpha‐fetoprotein. An abdominopelvic CT scan was performed and finally, the diagnosis of HB was confirmed by pathology. There was no history of congenital anomalies or risk factors for HB.Also we did not find any risk factors in the mother's history either. The only positive finding in the father's history was the use of anabolic steroids for bodybuilding. Anabolic‐androgenic anabolic steroids may be one of the possible causes of HB in children.
Metal‐Free Perovskites for X‐Ray Detection
Authors: Wu Yujiang , Li Zhizai , Lei Yutian , Jin Zhiwen 
Published: July 2023

AbstractMetal‐free perovskites are a promising class of materials for X‐ray detection due to their unique structural, optical, and electrical properties. Here, we first delve into the stoichiometry and geometric argument of metal‐free perovskites. Followed, the alternative A/B/X ions and hydrogen‐bonding are clearly introduced to further optimize the materials’ stability and properties. Finally, we provide a comprehensive overview of their potential applications for flexible X‐ray images and prospects for metal‐free perovskite development. In conclusion, metal‐free perovskite is a promising material for X‐ray detection. Its stoichiometric and geometric parameters, ion, and hydrogen bond selection, and application prospects are worthy of further study.
Naphthalene‐Embedded Multi‐Resonance Emitters Enabling Efficient Narrow Emissive Blue OLEDs**
Authors: Hou Peijie , Xu Yulin , Miao Jingsheng , Zhu Minrong , Liu He 
Published: July 2023

AbstractGreat achievements have been made in the development of organic light‐emitting diodes in recent decades. However, achieving high color purity for blue emitters remains a challenge. In this study, we have designed and synthesized three naphthalene (NA)‐embedded multi‐resonance (MR) emitters, named SNA, SNB and SNB1, based on N−B−O frameworks with isomer variations for finely adjusting the photophysical properties. These emitters show tunable blue emission with emission peaks of 450–470 nm. Small full width of half maximum (FWHM) of 25–29 nm are achieved in these emitters, indicating the well maintaining of molecular rigidity and MR effect with NA extension. Such design also ensures a fast radiative decay. However, no obvious delayed fluorescence is observed in all three emitters due to the relatively large energy differences between the first singlet and triplet excited states. Both SNA and SNB enable high electroluminescent (EL) performance in doped devices with external quantum efficiency (EQE) of 7.2 and 7.9 %, respectively. When applying the sensitized strategy, devices based on SNA and SNB show huge improvement with EQE of 29.3 and 29.1 %. More importantly, SNB with twist geometry enables stable EL spectra with almost unchanged FWHM under different doping concentrations. This work demonstrates the potential of NA extension design in constructing narrowband emissive blue emitters.
Diiminium Nucleophile Adducts Are Stable and Convenient Strong Lewis Acids**
Authors: Bormann Niklas , Ward Jas S. , Bergmann Ann Kathrin , Wenz Paula , Rissanen Kari , Gong Yiwei , Hatz Wolf‐Benedikt , Burbaum Alexander , Mulks Florian F. 
Published: July 2023

AbstractStrong Lewis acids are essential tools for manifold chemical procedures, but their scalable deployment is limited by their costs and safety concerns. We report a scalable, convenient, and inexpensive synthesis of stable diiminium‐based reagents with a Lewis acidic carbon centre. Coordination with pyridine donors stabilises these centres; the 2,2’‐bipyridine adduct shows a chelation effect at carbon. Due to high fluoride, hydride, and oxide affinities, the diiminium pyridine adducts are promising soft and hard Lewis acids. They effectively produce acylpyridinium salts from carboxylates that can acylate amines to give amides and imides even from electronically intractable coupling partners.
Long‐time correlations for a hard‐sphere gas at equilibrium
Authors: Bodineau Thierry , Gallagher Isabelle , Saint‐Raymond Laure , Simonella Sergio 
Published: July 2023

AbstractIt has been known since Lanford that the dynamics of a hard‐sphere gas is described in the low density limit by the Boltzmann equation, at least for short times. The classical strategy of proof fails for longer times, even close to equilibrium. In this paper, we introduce a weak convergence method coupled with a sampling argument to prove that the covariance of the fluctuation field around equilibrium is governed by the linearized Boltzmann equation globally in time (including in diffusive regimes). This method is much more robust and simpler than the one devised in Bodineau et al which was specific to the 2D case.
Unveiling the Reduction Process of Graphene Oxide by Ascorbic Acid: Grafting and Reduction Sequences for High Surface Area Graphene Materials
Authors: Ortiz‐Anaya Israel , Nishina Yuta 
Published: July 2023

AbstractThis work reports the synthesis of high surface area reduced graphene oxides using L‐ascorbic acid as a reducing agent by precisely controlling the interaction between graphene oxide and L‐ascorbic acid. Based on the structural characterization, such as textural properties (specific surface area, pore structure), crystallinity, and carbon chemical state, we identified that the temperature and reaction time are critical parameters to control the stacking degree of the final reduced product. Besides, by performing a time course analysis of the reaction, we identified the side products of the reducing agent by LC‐MS and verified the reduction mechanism. Following our results, we proposed an optimum condition for producing a graphene derivative adsorbent with a high surface area. This graphene derivative was tested in an aqueous solution with organic and inorganic pollutants such as methylene blue, methyl orange, and cadmium.
The efficacy of the dental Water Jet, orthodontic, and conventional toothbrushes in plaque removal around orthodontic braces in adolescents: A randomized controlled trial
Authors: Al Hariri Mhd Hadi , Karkoutly Mawia , Al Kurdi Saleh , Alkassar Mohammad , Bshara Nada 
Published: July 2023

AbstractObjectivesOrthodontic treatment improves both masticatory function and the aspects of facial esthetics through the correct alignment of the teeth. If oral hygiene is neglected during fixed orthodontic treatment, it may lead to plaque accumulation and gingivitis. The aim of this randomized controlled trial was to evaluate the effectiveness of the dental Water Jet (DWJ), and orthodontic toothbrush (O‐TH) in removing dental plaque around the orthodontic braces compared to conventional toothbrush (C‐TH) in adolescents.Materials and MethodsThis was a three‐arm, double‐blind, and parallel‐group randomized active‐controlled trial. Forty‐five patients were randomly allocated into three groups: DWJ, the O‐TH, and the C‐TH (control group). The primary outcome measure was dental plaque accumulation change from the baseline (t0) to post‐cleaning (t1), and plaque scores were recorded using the Orthodontic Plaque Index (OPI). The current clinical trial was registered and approved by Australian New Zealand Clinical Trials Registry (ACTRN12623000524695).ResultsA statistically significant difference was noted in the OPI scores between different time points in the DWJ group, the O‐TH group, and the C‐TH group (p < .05). However, no significant difference was noted between the groups after the cleaning procedure (p > .05).ConclusionThe level of oral hygiene was not satisfactory in patients undergoing fixed orthodontic treatment. In addition, the efficacy of the DWJ was not superior to O‐TH nor to C‐TH in plaque removal.
Resin cement selection for different types of fixed partial coverage restorations: A narrative systematic review
Authors: Ghodsi Safoura , Shekarian Mina , Aghamohseni Mohammad Mostafa , Rasaeipour Sasan , Arzani Sarah 
Published: July 2023

AbstractObjectiveThe aim of this study was to review the selection criteria of resin cements for different types of partial coverage restorations (PCRs) and investigate if the type of restorations or restorative materials affect the type of selected resin cement.Materials and MethodsAn electronic search (1991–2023) was performed in PubMed, Medline, Scopus, and Google Scholar databases by combinations of related keywords.ResultsA total of 68 articles were included to review the selection criteria based on the advantages, disadvantages, indications, and performance of resin cements for different types of PCRs.ConclusionsThe survival and success of PCRs are largely affected by appropriate cement selection. Self‐curing and dual‐curing resin cements have been recommended for the cementation of metallic PCRs. The PCRs fabricated from thin, translucent, and low‐strength ceramics could be adhesively bonded by light‐cure conventional resin cements. Self‐etching and self‐adhesive cements, especially dual‐cure types, are not generally indicated for laminate veneers.