bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival but not severity of hypoxic-ischemic encephalopathy is associated with higher mean arterial blood pressure after cardiac arrest: a retrospective cohort study
Authors: Preuß Sandra , Multmeier Jan , Stenzel Werner , Major Sebastian , Ploner Christoph , Storm Christian , Nee Jens , Leithner Christoph , Endisch Christian 
Published: March 2023

Abstract

Background: To study the association between mean arterial blood pressure (MAP), vasopressor requirement, and severity of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA).
Methods: Between 2008 and 2017, we retrospectively analyzed the MAP 200 hours after CA and quantified vasopressor requirements using the cumulative vasopressor index (CVI). Using postmortem brain autopsy in non-survivors, the severity of HIE was histopathologically dichotomized into no/mild and severe HIE. In survivors, we dichotomized the HIE severity into no/mild - Cerebral Performance Category (CPC) 1 – and severe HIE (CPC 4). Regain of consciousness, death causes and five-day survival were investigated as hemodynamic confounders.
Results: Among 350 non-survivors, 117 had histopathologically severe HIE and 233 no/mild HIE without differences in MAP (73.1 vs 72.0 mmHg, pgroup=0.639). Compared to non-survivors, 211 CPC 1 and 57 CPC 4 patients had higher MAPs that showed significant, but clinically non-relevant MAP differences (81.2 vs 82.3 mmHg, pgroup<0.001). No/mild HIE non-survivors (n=54) regaining consciousness before death had higher MAPs compared to no/mild HIE non-survivors (n=179) who remained persistently comatose (74.7 vs 69.3 mmHg, pgroup<0.001). No/mild HIE non-survivors regaining consciousness required less vasopressors (CVI 2.1 vs 3.6, pgroup<0.001). Independently of HIE severity, survivors were faster weaned from vasopressors (CVI 1.0).
Conclusions: Higher MAP was associated with survival but not HIE severity in CA patients treated with a vasopressor-supported MAP target above 65 mmHg. Awakening from coma was associated with less vasopressor requirements. Our results provide no evidence for a MAP target above current guideline recommendations to decrease the severity of HIE.
Enhanced electrocatalytic activity of Fluorine Doped Tin Oxide (FTO) by Trimetallic spinel ZnMnFeO4/CoMnFeO4 nanoparticles as a novel electrochemical sensor
Authors: Saei Jalal Niazi , Asadpour-Zeynali Karim 
Published: March 2023

Abstract
In the present study, ZnMnFeO4 and CoMnFeO4 tri-metallic spinel oxide nanoparticles (NPs) were provided using hydrothermal methods. The nanoparticles have been characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM) and electrochemical techniques. A reliable and reproducible electrochemical sensor based on ZnMnFeO4/CoMnFeO4/FTO was fabricated for rapid detection and highly sensitive determination of hydrazine by differential pulse voltammetry. It is observed the modified electrode causes a sharp growth in the oxidation peak current and a decrease in the potential for oxidation contrary to the bare electrode. The cyclic voltammetry technique showed, there is high electrocatalytic activity and excellent sensitivity in the suggested sensor for hydrazine oxidation. Under the optimal experimental conditions differential pulse voltammetry method was used for constructing the calibration curve and a linear range of 1.23 × 10− 6 M to 0.18 × 10− 3 M with a limit of detection 0.82 ± 0.09 µM was obtained. The obtained results indicate that ZnMnFeO4/CoMnFeO4/FTO nano-sensor bears pleasant stability, reproducibility, and repeatability in hydrazine measurements. In addition, the suggested sensor was employed efficiently to ascertain the hydrazine in diverse samples of cigarette tobacco.
Specialization of the brain for language in children with Fragile X Syndrome: A functional Near Infrared Spectroscopy study
Authors: Smith Elizabeth , Dominick Kelli C. , Schmitt Lauren M. , Pedapati Ernest V. , Erickson Craig A. 
Published: March 2023

Abstract
Specialization of the brain for language is early emerging and essential for language learning in young children. Fragile X Syndrome (FXS) is a neurogenetic disorder marked by high rates of delays in both expressive and receptive language, but neural activation for speech and language processing is unknown. We report results of a functional Near Infrared Spectroscopy (fNIRS) study of neural responses to speech sounds in children with FXS. Hemodynamic changes in the auditory cortex during blocks of speech and non-speech matched noise were measured in children with FXS and age-matched controls. Similar to controls, children with FXS showed activation of the primary auditory regions for speech and showed strong leftward lateralization. However, while controls showed neural differentiation of speech and nonspeech, children with FXS did not differentiate the two conditions. In addition, the children with FXS showed a greater response to the non-speech condition overall, which was associated with reduced verbal abilities.
Connectedness of quasi-heredity
Authors: Goto Yuichiro 
Published: March 2023

Abstract
Dlab and Ringel showed that algebras being quasi-hereditary in all orders for indices of primitive idempotents becomes hereditary. So, we are interested in for which orders a given quasi-hereditary algebra is again quasi-hereditary. As a matter of fact, we consider permutations of indices, and if the algebra with permuted indices is quasi-hereditary, then we say that this permutation gives quasi-heredity. In this article, we first give a criterion for adjacent transpositions giving quasi-heredity, in terms of homological conditions of standard or costandard modules over a given quasi-hereditary algebra. Next, we consider those which we call connectedness of quasi-heredity. The definition of connectedness can be found in \Cref{def of connected}. We then show that any two quasi-heredity are connected, which is our main result. By this result, once we know that there are two quasi-heredity, then permutations in some sense lying between them give also quasi-heredity.
MSC Classification: 16G20 , 06A05 , 20B30
Effect of carrot pomace and germinated chickpea soup mix on serum lipid profile in hyperlipidemic males
Authors: Gaur Supriya Singh , Kaur Navjot 
Published: March 2023

Abstract

Carrot pomace, a by-product obtained during carrot juice extraction is often discarded as waste however, the residue is rich in several nutrients that could lead to its application as functional ingredient for hyperlipidemic males. Two varieties namely, Punjab Carrot Red (PCR) and L-552 (chickpea seeds) were used for development of soup mix for hyperlipidemic patients by using 30% carrot pomace powder (CPP) and 50% germinated chickpea flour (GCF). Sixty hyperlipidemic subjects aged 30-60 years were supplemented with 12g sachet of soup mix on daily basis for 3 months to assess their anthropometric and biochemical profile during control and experimental period. Total antioxidant activity of CPP was found to be 68.45%, dietary fibre (60.49g) and β-carotene (1605.67μg) per 100g as compared to carrot powder. On the other hand, germinated chickpeas resulted in significant increase in protein (16.61%), antioxidant activity (22.77%) and vitamin C (3.01 mg/100g) content. Developed soup mix was reported to have antioxidant activity (25.74%), in-vitro protein digestibility (44.40%), β carotene (421.38 μg), ascorbic acid (1.32mg) and dietary fibre (34.01g) per 100g. After the experimental period, average daily intake of protein, dietary fibre, β carotene, ascorbic acid, iron, folic acid, magnesium and zinc increased (p<0.01) significantly in subjects. The weight, body fat %, BMI along with biochemical and blood profile showed a significant (p<0.01) reduction. It has been concluded that supplementation of soup mix developed using combination of carrot pomace and germinated chickpea resulted in significant improvement in anthropometric and biochemical profile of the subjects. The research protocol was approved by ethical committee of Punjab Agricultural University (No. DR.III.AU.2019/ 19589-98).
Construction and Validation of a Prognostic Signature based on Anoikis- related lncRNAs in Lung Adenocarcinoma
Authors: Dong Xiaoqi , Shao Chuan , Tu Jinjing , Chen Dahua , Xu Shuguang 
Published: March 2023

Abstract

Background
Lung adenocarcinoma (LUAD) is the most prevalent form of lung cancer, with high mortality and poor prognosis. Anoikis, a type of programmed cell apoptosis, plays a vital role in the progression of tumors. Herein, we established a signature based on anoikis-related lncRNAs to predict the prognosis of LUAD patients.
Method
Genomic and clinical data were downloaded from the TCGA database. Coexpression analysis and Cox regression were conducted to establish the prognostic signature. Kaplan–Meier curves and ROC curves were used to validate the accuracy of the model, and a nomogram based on the signature was constructed. Subsequently, gene set enrichment analysis, immune analysis and drug sensitivity analysis were performed.
Result
Nine anoikis-related lncRNAs (AC090912.1, LINC00707, AC026355.2, FOCAD-AS1, LINC00460, LINC01117, AC068228.1, AP000346.1 and LINC01537) were obtained to develop a prognostic signature. The K-M curves showed that the high-risk group was correlated with worse overall survival, progression-free survival and disease-specific survival. The area under the ROC curves for 1-, 3-, and 5-year overall survival (0.722, 0.704 and 0.709, respectively) and the C-index demonstrated that the signature has higher predictive value than clinical factors. Functional enrichment analysis showed that lncRANs participated in tumor progression. Patients in the low-risk group had a better prognosis, more immune cell infiltration, and higher immune scores. We also observed different sensitivities to anticancer drugs in the two groups, which can guide treatment.
Conclusion
We developed and estimated a novel anoikis-related lncRNA signature that may be used to predict the prognosis of LUAD patients.
All optical photonic crystal encoder based on nonlinear Kerr effect with ultrahigh contrast ratio and low threshold power
Authors: Bouaouina Mohamed Salah , Lebbal Mohamed Redha 
Published: March 2023

Abstract
Nowadays, miniaturized optical integrated circuits make a great evolution in optical microelectronics technology. In data processing chains, the need for an ultra-fast all-optical encoder is necessary for a large data transfer. In this work, we have proposed an all-optical encoder structure based on nonlinear 2D photonic crystals with Kerr effect exploiting a nonlinear polymer material of high third-order optical susceptibility. In addition, to generate the telecommunication domain wavelength at 1.55µm, an optimization of the optical-geometry parameters has been realized. Simulations will be performed using plane wave expansion and finite difference time domain methods. The nonlinear effect allows an excellent average contrast ratio of 39.76 db, as the structure requires a very low threshold intensity estimated at 1.5 mW/µm2. The significant power transmitted to the output is equal to 99% and 0.03% of input power equivalent to logic state “1” and logic state “0” respectively. The proposed structure generates a bit rate of 1.92Tb/s, therefore able to adapt with other ultrafast all-optical circuits.
Geochemical study of Lower Miocene anhydrites of Central Iran and their effect on the reservoir properties
Authors: Mazaheri Fatemeh 
Published: March 2023

Abstract

In the central basin of Iran, a clastic-carbonate reservoir, which is named Qom Formation, was deposited. Reservoir quality of this formation and effect of diagenesis on the reservoir properties evaluated in Yort-e Shah anticline; anhydritization is one of the diagenetic processes, which with occlude of pore system caused reduction of reservoir quality. Petrography study of the Qom Formation(c-4, d, e, and f members) indicates the presence of six anhydrite types including anhydrite layer, poikilotopic, pervasive, fracture filling cements, nodules and scattered and single anhydrite crystals. Diversity of anhydrite types show the effect of diagenesis processes in phreatic environment, near surface meteoric environment and burial environment, which they are affected to different degrees of diagenesis of reservoir facies. Based on geochemical study the environment towards top of Qom Formation become shallower and a lagoon with limited connection to see has been prevailed. Anhydritic layers with maximum thickness in “d” Member, act as a continues cap-rock for the lower reservoirs. Other types of anhydrite are sporadic in the Qom members and have a low percentage; therefore, they could slightly reduce the reservoir quality of this formation. Porosity distribution in the Qom members is affected by their facies that caused different rate of cementation. Due to changing facies in the members of Qom Formation, fracture porosity just extended in e and f members and it caused increasing permeability and consequently the reservoir qualities of them so they are suitable parts for gas storage project. Determination rate of anhydrite as one of the sources listed in H2S is helpful for reduction of risk assessment of gas storage project in Qom members.
Dipole and Cluster Dipole States of HPGe Detectors at Cryogenic Temperature
Authors: Raut Mathbar , Mei Dongming , Bhattarai Sanjay , Panth Rajendra , Kooi Kyler , Mei Hao , Wang Guojian 
Published: March 2023

Abstract
This study investigates new technology for enhancing the sensitivity of low-mass dark matter detection by analyzing charge transport in a p-type germanium detector at 5.2 K. To achieve low-threshold detectors, precise calculations of the binding energies of dipole and cluster dipole states, as well as the cross-sections of trapping affected by the electric field, are essential. The detector was operated in two modes: depleted at 77 K before cooling to 5.2 K and cooled directly to 5.2 K with various bias voltages. Our results indicate that the second mode produces lower binding energies and suggests different charge states under varying operating modes. Notably, our measurements of the dipole and cluster dipole state binding energies at zero fields were 8.716+/-0.435 meV and 6.138+/-0.308$ meV, respectively. These findings have strong implications for the development of low-threshold detectors for detecting low-mass dark matter in the future.
Multiply-connected complementary Hall-plates with extended contacts
Authors: Ausserlechner Udo 
Published: March 2023

Abstract
We consider uniform plane Hall-plates with an arbitrary number of holes exposed to a uniform perpendicular magnetic field of arbitrary strength. The plates have extended contacts on the outer boundary and on the boundaries of the holes. No symmetry is presumed. Pairs of complementary Hall-plates are defined, where contacts and insulating segments on the boundaries are swapped. A unique stream function exists in these multiply-connected domains if the total current through each boundary vanishes. Then the voltages between neighbouring contacts and the currents into contacts of pairs of complementary Hall-plates are linked in a peculiar way, which results in identical power density. Relations between the impedances of complementary multiply-connected Hall-plates are derived. The prominent role of complementary symmetric Hall-plates - with or without holes - is revealed. For arbitrary magnetic field their resistance equals the one of a square without holes and with contacts fully covering two opposite edges.
MSC Classification: 31A02 , 35C05 , 78A30
The Boundaries of Law: Main Aspects of the Problem
Authors: Rabinovych Petro , Honcharov Volodymyr 
Published: March 2023

The article is devoted to the analysis of the boundaries of law through three main topics, which are anthropic, human rights, and legal-regulatory boundaries. Such minimal differentiation seems necessary, in particular, to prevent the substitution or eclecticism of ambiguous terms and thevery conclusions of scientific analysis. The first aspect is based on the so-called “natural” understanding of the law; the second – on the so-called Legist-positivist understanding; and the third – on a certain combination (integration) of the first two aspects.Anthropocentric boundaries stem from the fact that man (as a unique biosocial being) is the primary source of all its fundamental (existential) rights, beyond which its existence and development The article is devoted to the analysis of the boundaries of law through three main topics,which are anthropic, human rights, and legal-regulatory boundaries. Such minimal differentiation seems necessary, in particular, to prevent the substitution or eclecticism of ambiguous terms and the very conclusions of scientific analysis. The first aspect is based on the so-called “natural” understandingof the law; the second – on the so-called Legist-positivist understanding; and the third – on a certain combination (integration) of the first two aspects.Anthropocentric boundaries stem from the fact that man (as a unique biosocial being) is the primary source of all its fundamental (existential) rights, beyond which its existence and development.
Max Weber’s Paradox of Consequences in the Context of Ukrainian Constitutionalism
Authors: Rechytskyi Vsevolod 
Published: March 2023

The article considers the phenomenon of Max Weber’s “paradox of consequences” in the context of the issue of Ukrainian constitutionalism. According to the author, Ukraine has only recently begun the process of mental liberation from totalitarianism, which significantly influenced the design of the 1996 Constitution of Ukraine. The main shortcomings of Ukrainian constitutionalism, the author considers its non-market, post-socialist nature. This affects boththe form and the in-depth content of a number of key constitutional norms.
The author shows that modern Ukrainian constitutionalism continues to be a distant successor to the utopian socialist project, which has a negative impact on the economy, politics and culture of modern Ukraine, the vector of its progress. The article contains arguments in favor of a broad constitutional renewal of Ukraine, up to the development of a new Basic Law.The author’s argument is based on a wide range of illustrative material. The author turns to sources of historical, political and aesthetic nature, which allows him to reveal the topic in a non-standard, original style. Despite the appeal to scientific arguments, the author of the article also appeals to themoral and aesthetic feelings of his audience. He argues that organic constitutionalism is associated not only with rational, but also irrational, sensual beginnings. In his view, the content of modern constitutionalism is freedom of choice and private property in their very broad sense. He insists that the stars of modern business and trade must have a separate political representation in Ukraine.The Senate as the upper house of the renewed parliament of Ukraine can become such a representation. The article is part of a number of the author’s publications on informal constitutionalism. It reflects only one aspect of his views on European and American constitutionalism. In general, the article embodies a strongly critical view of the rule of law in Ukraine. On the other hand, it demonstrates the author’s desire to honestly understand ata professional level the shortcomings and achievements of modern legal policy of Ukraine.Stylistically, the article promises to be interesting not only for lawyers. It may be of equal interest to specialists in political science, philosophy and theory of law.
La evaluación de programas de preparación para la universidad: un pendiente en la educación latinoamericana
Authors: Hoyos Figueroa Alexandra , Hernndez Enriquez Colombia , Vélez Santamaría Héctor Hernán 
Published: March 2023

Este artículo destaca los principales aspectos de una revisión sistemática de artículos publicados en revistas indexadas que evaluaron el efecto de intervenciones orientadas hacia la preparación de estudiantes para ingresar y cursar de manera exitosa programas de educación superior universitaria. Los textos revisados fueron encontrados en bases de datos bibliográficas mediante el marco conceptual formulado por Conley. La revisión revela la frecuencia de las intervenciones dirigidas a fortalecer contenidos académicos. Estas inciden positivamente en la mejora de los promedios durante el bachillerato, el ingreso, el desempeño y la graduación en la educación superior. Los cursos universitarios integrados al currículo del bachillerato se destacan como una de las intervenciones más potentes para promover el conocimiento de la universidad, fortalecer estrategias cognitivas y comportamientos académicos de los estudiantes, y mejorar sus percepciones y expectativas de ingreso al mundo universitario, tanto como su motivación, autoconfianza y persistencia de participación en él. La comparación de las políticas públicas que sustentan programas afines desarrollados en Latinoamérica destaca la evaluación de las intervenciones de preparación para la universidad como una labor pendiente para sustentar y mejorar la toma de decisiones en la política de educación superior universitaria.
Gestión académica y administrativa para una educación inclusiva considerando necesidades educativas especiales
Authors: Rojas Jahaira , Inga Esteban 
Published: March 2023

El desarrollo de la presente investigación se enfoca en analizar la eficiencia que presenta la gestión académica y administrativa de los educadores, en la inclusión de estudiantes con deficiencias cognitivas a un aula regular, la investigación se desarrolló dentro de un marco metodológico, cuantitativo con un enfoque descriptivo, mediante el cual se pudo analizar las características y comportamientos que presentan los estudiantes con deficiencias de aprendizaje, así como también las acciones que efectúan los docentes para facilitar el proceso de enseñanza, para la obtenciones los datos se determinó como técnica dos encuestas, la una dirigida a los docentes de las diferentes unidades educativas con cargos administrativos y de aula, la segunda dirigida a los padres que tiene estudiantes con deficiencias cognitivas, en la tabulación de los datos se utilizó como herramienta software estadístico, mediante el cual se graficó y se porcentualiza la información, el análisis de los resultados denotó la importancia que tiene la acogida que proporcionan los docentes en la integración de los niños con deficiencias de aprendizaje.