bluuebunny/crossref_metadata_2025_split huggingface dataset:
What do Australians affected by cancer think about oncology researchers sharing research data: a cross-sectional survey
Authors: Hamilton Daniel G. , Everitt Sarah , Page Matthew J. , Fidler Fiona 
Published: May 2023

ObjectivesTo characterise the attitudes of Australians affected by cancer towards the sharing of de-identified research data with third parties, including the public.Design, setting, participantsAnonymous online survey between October 2022 and February 2023 of adult Australians previously diagnosed with cancer.Main outcome measuresSelf-reported attitudes towards the sharing of human and non-human data, and the hypothetical sharing of their anonymised medical information and responses to the survey.Results551 respondents contributed data to the survey. There was strong support for cancer researchers sharing non-human and de-identified human research data with medical doctors (90% and 95% respectively) and non-profit researchers (both 94%). However, this declined when participants were asked whether data should be shared with for-profit researchers (both 64%) or posted publicly (both 61%). When asked if they would hypothetically consent to researchers at their treatment location collecting and sharing their de-identified data publicly, only half agreed (50%). In contrast, after being shown a visual representation of the de-identified survey data, 80% of respondents supported sharing it publicly. A further 10% also supported public sharing of some of the survey data, with the most frequently desired information to be withheld including education history and levels of trust in healthcare stakeholders.ConclusionsAustralians affected by cancer support the sharing of research data, particularly with clinician and non-profit researchers. Visualisation of the data to be shared may also enhance support for making research data publicly available. These results should help alleviate any concerns about research participants’ attitudes on data sharing, as well as boost researchers’ motivation for sharing.
MDverse: Shedding Light on the Dark Matter of Molecular Dynamics Simulations
Authors: Tiemann Johanna K. S. , Szczuka Magdalena , Bouarroudj Lisa , Oussaren Mohamed , Garcia Steven , Howard Rebecca J. , Delemotte Lucie , Lindahl Erik , Baaden Marc , Lindorff-Larsen Kresten , Chavent Matthieu , Poulain Pierre 
Published: May 2023

AbstractThe rise of open science and the absence of a global dedicated data repository for molecular dynamics (MD) simulations has led to the accumulation of MD ﬁles in generalist data repositories, constituting thedark matter of MD— data that is technically accessible, but neither indexed, curated, or easily searchable. Leveraging an original search strategy, we found and indexed about 250,000 ﬁles and 2,000 datasets from Zenodo, Figshare and Open Science Framework. With a focus on ﬁles produced by the Gromacs MD software, we illustrate the potential offered by the mining of publicly available MD data. We identiﬁed systems with speciﬁc molecular composition and were able to characterize essential parameters of MD simulation such as temperature and simulation length, and could identify model resolution, such as all-atom and coarse-grain. Based on this analysis, we inferred metadata to propose a search engine prototype to explore the MD data. To continue in this direction, we call on the community to pursue the effort of sharing MD data, and to report and standardize metadata to reuse this valuable matter.
Controlled tumor heterogeneity in a co-culture system by 3D bio-printed tumor-on-chip model
Authors: Moghimi Nafiseh , Hosseini Seied Ali , Dalan Altay Burak , Mohammadizadeh Dorsa , Goldman Aaron , Kohandel Mohammad 
Published: May 2023

AbstractBackgroundCancer treatment resistance is a consequence of cell diversity and tumor heterogeneity. Tumor cell-cell and cell-microenvironment interactions significantly influence tumor progression and invasion, which have important implications for diagnosis, therapeutic treatment and chemoresistance.MethodIn this study, we develop 3D bioprinted in vitro models of the breast cancer tumor microenvironment (TME) made of co-cultured cells distributed in a hydrogel matrix with controlled architecture to model tumor heterogeneity. We hypothesize that the tumor could be represented by a cancer cell-laden co-culture hydrogel construct, whereas its microenvironment can be modeled in a microfluidic chip capable of producing a chemical gradient. Breast cancer cells (MCF7 and MDA-MB-231) and non-tumorigenic mammary epithelial cells (MCF10) were embedded in the alginate-gelatine hydrogels and printed using a multi-cartridge extrusion bioprinter.ResultsOur method gives special control on the cell positions in the co-culture system, whereas different tumor architectures can be designed. Cellularly heterogeneous samples comprised of two different cancer cells with controlled density are developed in specific initial locations, i.e. two cell types randomly mixed or positioned in sequential layers. A migration-inducing chemical microenvironment was created in a chamber with a gradual chemical gradient to study the cell migration in the complex tumor construct toward the chemoattractant. As a proof of concept, the different migration pattern of MC7 cells toward the epithelial growth factor gradient was studied with presence of MCF10 in different ratio in this device.ConclusionCombining 3D bioprinting with microfluidic device in our method provides a great tool to create different tumor architectures as can be seen in different patients, and study cancer cells behaviour with accurate special and temporal resolution.
FIRST RECORD OFMELANAPHIS SORGHI(THEOBALD, 1904) (HEMIPTERA APHIDIDAE) IN ITALY AND SPAIN
Authors: Casiraghi Alice , Addelfio Nicola , Ardenghi Nicola M. G. , Hidalgo Nicolás Pérez 
Published: May 2023

ABSTRACTThe sorghum aphidMelanaphis sorghi(Theobald) is recorded for the first time in mainland Italy (Florence, Tuscany region, Italy) and Spain (Vinalesa, Valencia Region, Spain) onSorghum halepense(L.) Pers. Data on its biology, worldwide distribution and notes on its pest behaviour are given.Melanaphis sorghihad previously been recorded from Greece (in 2008), Cyprus and Israel. The records of this species in Iran and Turkey need confirmation.
Persistent delay in maturation of the developing gut microbiota in infants with cystic fibrosis
Authors: Salerno Paige , Verster Adrian , Valls Rebecca , Barrack Kaitlyn , Price Courtney , Madan Juliette , O’Toole George A. , Ross Benjamin D. 
Published: May 2023

ABSTRACTThe healthy human infant gut microbiome undergoes stereotypical changes in taxonomic composition between birth and maturation to an adult-like stable state. During this time, extensive communication between microbiota and the host immune system contributes to health status later in life. Although there are many reported associations between microbiota compositional alterations and disease in adults, less is known about how microbiome development is altered in pediatric diseases. One pediatric disease linked to altered gut microbiota composition is cystic fibrosis (CF), a multi-organ genetic disease involving impaired chloride secretion across epithelia and heightened inflammation both in the gut and at other body sites. Here, we use shotgun metagenomics to profile the strain-level composition and developmental dynamics of the infant fecal microbiota from several CF and non-CF longitudinal cohorts spanning from birth to greater than 36 months of life. We identify a set of keystone species whose prevalence and abundance reproducibly define microbiota development in early life in non-CF infants, but are missing or decreased in relative abundance in infants with CF. The consequences of these CF-specific differences in gut microbiota composition and dynamics are a delayed pattern of microbiota maturation, persistent entrenchment in a transitional developmental phase, and subsequent failure to attain an adult-like stable microbiota. We also detect the increased relative abundance of oral-derived bacteria and higher levels of fungi in CF, features that are associated with decreased gut bacterial density in inflammatory bowel diseases. Our results define key differences in the gut microbiota during ontogeny in CF and suggest the potential for directed therapies to overcome developmental delays in microbiota maturation.
A scoping umbrella review to identify anti-racist interventions to reduce ethnic disparities in health and care
Authors: Yip Jennifer L Y , Poduval Shoba , Souza-Thomas Leah de , Carter Sophie , Fenton Kevin 
Published: May 2023

Structured AbstractObjectivesTo identify anti-racist interventions which aim to reduce ethnic disparities in health and care.Eligibility criteria for selecting studiesOnly studies reporting systematic reviews of anti-racist interventions were included. Studies were excluded if no interventions were reported, no comparators reported, or the paper was primarily descriptive.The following databases were searched: Embase, Medline, Social Policy and Practice, Social care online and Web of Science. Quality appraisal (including risk of bias) was assessed using the AMSTAR-2 tool.Due to the nature of the selected reviews, the lack of meta-analyses and heterogeneity of included studies, a narrative synthesis using an inductive thematic analysis approach was conducted to integrate and categorise the evidence on anti-racist interventions for health and care.ResultsA total of 18 systematic reviews are included in the final review. 15 are from the healthcare sector and three are from education and criminal justice. 17 reviews are focused on interventions and one focused on implementation. All 18 reviews described interventions which targeted individuals and their communities, and 11 reviews described interventions targeting both individuals and communities, and healthcare organisations. On an individual level, the most promising interventions reviewed include group-based health education led by professional staff and providing culturally tailored or adapted interventions. On a community level, participation in all aspects of care pathway development that empowers ethnic minority groups may provide an effective approach to reducing ethnic health disparities. Targeted interventions to improve clinician patient interactions and quality of care for conditions with disproportionately worse outcomes in ethnic minority groups show promise.DiscussionMany of the included studies were low or critically low quality due to methodological or reporting limitations. The heterogeneity of intervention approaches, study designs, and limited reporting of cultural adaptation, implementation and lack of comparison with White ethnic groups limited our understanding of the impact on ethnic health inequalities.In summary, for programme delivery, different types of pathway integration and providing a more person-centred approach with fewer steps for patients to navigate can contribute to reducing disparities. For organisations, there is an overemphasis on patient education and individual behaviour change rather than organisational change, and recommendations should include a shift in focus and resources to policies and practices that seek to dismantle institutional and systemic racism through a multi-level approach.
Migratory bats are sensitive to magnetic inclination during compass calibration
Authors: Schneider William T. , Holland Richard A. , Keišs Oskars , Lindecke Oliver 
Published: May 2023

ABSTRACTThe Earth’s magnetic field is used as a navigational cue by many animals. For mammals, however, there is little data to show that navigation ability relies on sensing the natural magnetic field. In migratory bats, however, the calibration of a magnetic compass became plausible following experiments demonstrating a role for the solar azimuth at sunset in their orientation system. Here, we investigated how an altered magnetic field at sunset changes the nocturnal orientation of the batPipistrellus pygmaeus. We exposed bats to either the natural magnetic field, a horizontally shifted field (120°), or the same shifted field combined with a reversal of the natural value of inclination (70° to −70°). We later released the bats and found that the take-off orientation differed between all treatments. Bats that were exposed to the 120° shift were unimodally oriented northwards, in contrast to controls which exhibited a North-South distribution. Surprisingly, the orientation of bats exposed to both a 120°-shift and reverse inclination was indistinguishable from a uniform distribution. These results provide the missing link that these migratory bats calibrate a magnetic compass at sunset, and for the first time, they show that bats are sensitive to the angle of magnetic inclination.
The impact of global renewable energy demand on economic growth – evidence from GCC countries
Authors: Lahrech Abdelmounaim , Abu-Hijleh Bassam , Aldabbas Hazem 
Published: May 2023

PurposeThis study aims to examine the relationship between global renewable energy consumption and economic growth in Gulf Cooperation Council (GCC) countries from 2001 to 2019.Design/methodology/approachThis paper used a panel regression model to study the six GCC countries over the period from 2001 to 2019.FindingsAs expected, the findings indicated a significant and negative relationship between global renewable energy consumption and GCC economic growth. Additionally, there was a positive and significant relationship between GCC economic growth and the control variables, specifically labor, capital, CO2 emissions and non-renewable energy production.Practical implicationsThe results are of great importance to policymakers in GCC oil-exporting countries, as expected growth in renewable energy consumption will lower their economic growth in the future. Hence, they should first diversify their economy and lower their dependence on oil. Second, these countries can invest in solar energy through international joint ventures, especially with North African countries in close proximity to Europe, to become leaders in solar energy production.Originality/valueHow global energy consumption is related to GCC countries’ economic growth remains unclear, not only in GCC countries but also in many oil-exporting countries around the world, so future studies are needed. Furthermore, GCC governments will be able to create appropriate policies for the green economy and achieve their objectives if they have a comprehensive understanding of how global growth in renewable energy demand affects GCC economies.
Efficiency analysis of the OECD countries' long-term productivity using DEA and TOPSIS approaches
Authors: Wanke Peter , Antunes Jorge Junio Moreira , Filgueira Antônio L. L. , Michelotto Flavia , Tardin Isadora G. E. , Tan Yong 
Published: May 2023

PurposeThis paper aims to investigate the performance of OECD countries' long-term productivity during the period of 1975–2018.Design/methodology/approachThis study employed different approaches to evaluate how efficiency scores vary with changes in inputs and outputs: Data Envelopment Analysis (CRS, VRS and FDH), TOPSIS and TOPSIS of these scores.FindingsThe findings suggest that, during the period of this study, countries with higher freedom of religion and with Presidential democracy regimes are positively associated with higher productivity.Originality/valueTo the best of the authors’ knowledge, this is the first study that uses efficiency models to assess the productivity levels of OECD countries based on several contextual variables that can potentially affect it.
Training needs of built environment professionals: the role of fourth industrial revolution
Authors: Ebekozien Andrew , Aigbavboa Clinton Ohis , Adekunle Samuel Adeniyi , Aliu John , Thwala Wellington Didibhuku 
Published: May 2023

PurposeStudies show that the twenty-first-century construction industry needs reskilling and upskilling tools to train large numbers of the workforce for better-integrated project delivery. Evidence shows that digitisation via the fourth industrial revolution (4IR) technology can play a critical role in reskilling and competency demand. Attempting to use digital technology may have had some challenges. Studies about the perceived hindrances facing Nigeria's built environment professionals (BEP) reskilling and upskilling needs in the workplace via 4IR technologies are scarce. Thus, the study investigated the perceived encumbrances facing Nigeria's BEP training needs and proffered measures to improve their performance in the workplace via 4IR technologies.Design/methodology/approachThe researchers engaged BEP in Lagos and Abuja, Nigeria. Regarding the data collection, a qualitative research design was adopted. The study achieved saturation after 32 virtual interviews. A thematic analysis was adopted for the collected data.FindingsThe study shows that using 4IR for reskilling and upskilling will enhance integrated project delivery. But the level of usage in training needs is low. Findings identified the various ways reskilling and upskilling could be achieved. Also identified are the major built environment areas that require 4IR training. Findings highlighted possible encumbrances facing the use of 4IR technologies by Nigerian BEP for reskilling and upskilling needs in the workplace and proffered feasible measures to improve 4IR usage for training needs.Research limitations/implicationsThe study is restricted to the perceived encumbrances and proffers measures to improve BEP reskilling and upskilling needs via 4IR technologies via a qualitative method. Future research is required to validate the findings and test the proposed framework that emerged from the study.Practical implicationsThe study confirms that reskilling and upskilling measures are required at all skill levels and may lead to economic growth. The paper would advance Nigerian higher educational accreditation agencies and various BEP regulatory bodies to review the curriculum and incorporate 4IR as a component or module.Originality/valueThe thematic network analysis and proposed framework could be utilised to stimulate Nigeria's BEP reskilling and upskilling needs in the workplace via 4IR technologies. It would stir main stakeholders, especially government policymakers, to facilitate programmes to improve 4IR technologies usage.
A framework of accelerator design: harmonizing fragmented knowledge
Authors: Kramer Alexander , Veit Philipp , Kanbach Dominik K. , Stubner Stephan , Maran Thomas K. 
Published: May 2023

PurposeThe purpose of this article is to develop an integrative framework of accelerator design to answer the question of what activities accelerators perform and how they function within a structured framework. Research on the functioning of accelerators as a mechanism for startup engagement produced multiple empirical results. However, the comparability of relevant research is strongly limited, currently hindering theoretical developments. Existing accelerator design models often differ and only partially overlap, which leaves extant literature with a fragmented and discordant conceptual understanding.Design/methodology/approachBased on a meta-synthesis method using qualitative analysis of 36 accelerator design articles, an integrative framework is developed. After identification of relevant literature, a renowned method for extracting, coding and synthesizing data on individual and cross-study level is applied to identify accelerator design constructs. Eventually, identified accelerator design constructs are integrated into a framework resting on the activity system lens of business model design.FindingsThe article reconciles fragmented knowledge on accelerator design and shows how accelerator design can be holistically conceptualized by 32 key activities clustered in eight design dimensions. The framework is complemented by an initial guideline for measurement. The findings further highlight formerly disregarded aspects of governance and community formation from a processual and structural perspective.Originality/valueThis article is the first to present a comprehensive picture of accelerator design integrating multiple empirical findings of prior research into a single coherent framework. This framework offers a shared foundation for future research exploring the delineations, functioning and impact of accelerators. From a practical perspective, the article provides managers of accelerators a guide to design, review and improve programs according to their value creation goals.
“I. Am. a. Star.”: exploring moments of muchness in children’s digital compositional play and embodied science learning
Authors: Woodard Rebecca , Diaz Amanda R. , Phillips Nathan C. , Varelas Maria , Kotler Rebecca , Tsachor Rachelle Palnick , Rock Ronan , Melchor Miguel 
Published: May 2023

PurposeThe purpose of this study is to examine playful practices in the science video composition of a fourth-grader.Design/methodology/approachWith an analytic interest in “chasing the theory of muchness” (Thiel, 2015a) that describes distinctive moments of affective energies in playful learning, the authors explored a child’s video in which a food chain is dramatized.FindingsThe authors identified how muchness manifested in/through her compositional play.Originality/valueThe potential of playful composing and dramatizing to support meaning-making across contexts and disciplines is discussed.
Playful pluralities: exploring play and playful literacies across ages, spaces and places
Authors: Mannard Emily 
Published: May 2023

PurposePlay and playful literacies shape essential spaces for belonging, connection, transformation and joy: from embodied immersions into fantasy worlds, to the creation of interest-led groups overflowing with varied knowledges and identities, and the disruption of societal hierarchies through roleplayed restorying. Yet, theorizations delineating playful possibilities – while plentiful and varied – are often rigidly constructed in relation to neoliberally/biopolitically motivated notions of value, use and productivity. Imbued with forms of modern power, play’s full flourishing has been regulated and quelled, particularly within the realm of education. This study, a literature review, seeks to defy this fatuous notion of a frivolous play.Design/methodology/approachDrawing from research within the fields of literacy and educational studies, the author centers playful methods commonly trivialized in contemporary discourse, including in global out-of-school spaces (e.g. gaming clubs, improvisational theater groups), with popular culture texts (e.g. picture books, digital fanfiction) and for older youth and adults.FindingsThis exploration of play’s potential across lifespans, formal/informal learning ecologies and worldwide contexts foregrounds its intrinsic nature and essential entwining with socio-culturally/materially mediated forms of knowledge and communication.Originality/valueWith a unique focus on the playful literacies emerging across ages, spaces and places, this review advocates a turn toward the imaginative, messy, uncontrollable worlds of play in future research and practice.