bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of global orbital shape variation
Authors: Prevost Alice , Muller Samuel , Lauwers Frédéric , Heuzé Yann 
Published: January 2023

AbstractThe complex anatomy of the orbit generates a complex orbital shape that can only be quantified approximatively by classic linear measurements such as maximum width and height. There is no global three‐dimensional quantification of variations in orbital shape. The purpose of this study was to develop a method to quantify a global three‐dimensional orbital shape variation in a healthy population and to test a series of explanatory factors. We investigated the hypotheses that orbital shape is related to gender(H1), orbital size(H2) and/or age(H3). Medical computed tomography(CT) images of 60 adult individuals were studied. The study sample consisted of 30 males and 30 females with a mean age of 25.1 years. Four anatomical landmarks and 140 semi‐landmarks were measured on both positive and negative 3D reconstructed orbits and analyzed with geometric morphometrics. A principal component analysis(PCA) was computed to define a morphological space. Shape variation was visualized using vector distance maps and diagrams. The greatest variation was seen in the length of the superior orbital fissure. There was a gradient in terms of orbital shape ranging from short, wide orbits to tall, narrow orbits. The analysis did not highlight any significant age‐, gender‐ or size‐related impact in terms of orbital shape variation. Future avenues to explore include the study of other potential explanatory factors such as the different embryological origins of the orbital bones, the passage of vessels and nerves, and ethnic origins. This method can also be applied to the study of pathological orbits.
Long‐term outcomes of frontline intensification in primary CNS lymphoma: A real‐world single‐center experience
Authors: Wang Hao‐Yuan , Yang Ching‐Fen , Lin Chia‐Hsin , Hsiao Liang‐Tsai , Ko Po‐Shen , Liu Yao‐Chung , Chiou Tzeon‐Jye , Chen Po‐Min , Gau Jyh‐Pyng , Liu Jin‐Hwang , Liu Chia‐Jen 
Published: January 2023

AbstractBackgroundFrontline intensification (including consolidative whole‐brain radiotherapy or high‐dose chemotherapy with autologous stem‐cell transplantation after induction therapy) has been proposed to treat primary central nervous system lymphoma (PCNSL). However, no prospective randomized trials have answered whether frontline intensification can offer a survival benefit to PCNSL patients. We aim to clarify the outcomes and survival influence of frontline intensification on real‐world patients with different risk‐stratified PCNSLs.MethodsBetween January 2003 and December 2016, 110 PCNSL adults were retrospectively included, and 76 patients achieved at least PR after induction therapy, including 38 patients who received frontline intensification. The median follow‐up with the 31 survivors was 7.52 years.ResultsOf the 38 induction‐completed patients who had not received frontline intensification, 95% achieved post–induction therapy CR/CRu; however, all inevitably recurred. In the 38 who received frontline intensification, CR/CRu improved from 45% (pre‐frontline intensification) to 84% (post‐frontline intensification), and they achieved significantly better PFS (non‐reach vs. 522 days, p < 0.001) and OS (non‐reach vs. 899 days, p < 0.001). Additionally, patients had similar PFS and OS rates when receiving HDC‐ASCT and/or WBRT as frontline intensification. Frontline intensification significantly improved PFS and OS survival in higher‐risk patients (intermediate/high IELSG risk, MSKCC group 2/3, or Nottingham/Barcelona score ≥ 2 points) but did not improve OS in lower‐risk patients. Among the 38 patients who received frontline intensification, two had treatment‐related mortality; 14 recurred after frontline intensification. MTX‐based chemotherapy was the main salvage modality, and the median OS was 295 days after recurrence. Progressive disease and infection (especially pneumonia) are two major causes of mortality in patients who receive frontline intensification.ConclusionsWhen achieving CR/CRu/PR after induction chemotherapy, frontline intensification should be adopted to improve PFS and OS in real‐world PCNSL patients, especially higher‐risk patients.
Evaluation of changes to work patterns in multidisciplinary cancer team meetings due to the COVID‐19 pandemic: A national mixed‐method survey study
Authors: Soukup Tayana , Winters David , Chua Kia‐Chong , Rowland Philip , Moneke Jacqueline , Skolarus Ted A. , Bharathan Rasiah , Harling Leanne , Bali Anish , Asher Viren , Gandamihardja Tasha , Sevdalis Nick , Green James S. A. , Lamb Benjamin W. 
Published: January 2023

AbstractBackgroundIt is not well understood the overall changes that multidisciplinary teams (MDTs) have had to make in response to the COVID‐19 pandemic, nor the impact that such changes, in addition to the other challenges faced by MDTs, have had on decision‐making, communication, or participation in the context of MDT meetings specifically.MethodsThis was a mixed method, prospective cross‐sectional survey study taking place in the United Kingdom between September 2020 and August 2021.ResultsThe participants were 423 MDT members. Qualitative findings revealed hybrid working and possibility of virtual attendance as the change introduced because of COVID‐19 that MDTs would like to maintain. However, IT‐related issues, slower meetings, longer lists and delays were identified as common with improving of the IT infrastructure necessary going forward. In contrast, virtual meetings and increased attendance/availability of clinicians were highlighted as the positive outcomes resulting from the change. Quantitative findings showed significant improvement from before COVID‐19 for MDT meeting organisation and logistics (M = 45, SD = 20) compared to the access (M = 50, SD = 12, t(390) = 5.028, p = 0.001), case discussions (M = 50, SD = 14, t(373) = −5.104, p = 0.001), and patient representation (M = 50, SD = 12, t(382) = −4.537, p = 0.001) at MDT meetings.DiscussionOur study explored the perception of change since COVID‐19 among cancer MDTs using mixed methods. While hybrid working was preferred, challenges exist. Significant improvements in the meeting organisation and logistics were reported. Although we found no significant perceived worsening across the four domains investigated, there was an indication in this direction for the case discussions warranting further ‘live’ assessments of MDT meetings.
The experience of counselling for UK egg providers
Authors: Loyal Sasha , Hudson Nicky , Culley Lorraine , Weis Christina 
Published: January 2023

AbstractObjectiveThe aim of this study was to address current gaps in knowledge regarding the appropriateness and quality of counselling provided to egg donors in the UK.MethodsThe present study used a cross‐sectional, qualitative design. Semi‐structured interviews were carried out with 29 UK egg donors to explore their experiences of egg donation and the counselling received.ResultsOf the 29 participants, 24 had received counselling. The remaining five did not receive counselling because they were either not accepted as a donor (n = 4) or were offered, but chose not to take up the session (n = 1). The findings are presented in relation to five themes: feeling supported via counselling; feeling well‐informed; welcoming an individualised approach; the counselling setting; and thinking about the future.ConclusionEgg donors in this study had varying experiences of counselling offered to them as part of the egg donation process in the UK.ImplicationsThe findings indicate that there are some aspects of counselling in the UK that could be improved, including the routine offering of counselling throughout the egg donation process and the tailoring of counselling to meet egg donors' individual needs.
Disorganized attachment, mentalization and dissociation in context of childhood trauma: Implications for depressive symptoms
Authors: Bogdanović Aleksandra , Radev Milica Tošić , Stanojević Tatjana Stefanović 
Published: January 2023

AbstractExtensive evidence indicates that adults with experience of childhood trauma and disorganised attachment are at a higher risk of suffering from depressive symptoms, while at the same time dissociation and mentalisation are very important risk and protective factors in this relation. Although mentalisation and dissociation are mentioned as potential mediators of this relationship, very few studies have analysed the mutual relations between these variables. Bearing in mind the importance of creating more specific and effective ways for dealing with depression, especially within vulnerable groups such as the traumatised, the aim of this research is to examine a serial mediation model in which disorganisation is modelled as effecting a decrease in mentalisation, in turn lead to dissociation, thereby resulting in depressive symptoms. Adult respondents (N = 153) with a history of interpersonal childhood trauma were selected from a larger geographical cluster sample from the general population of Serbia. The respondents filled in a battery of instruments, including The Childhood Traumatic Events Scale, Relationship Questionnaire – CV, Patient Health Questionnaire, Short Scale for the Assessment of Stress‐Related Dissociation Symptomatology and the Mentalisation Scale. Our findings suggest that disorganisation has an effect on depression by leading to a decrease in the ability to mentalise, which further triggers dissociation, resulting in depressive symptoms as a final consequence (estimated indirect effect = 0.014, 95 percent CI = 0.005 to 0.026). Additionally, the specific indirect effect involving dissociation as the sole mediator was also significant (estimated indirect effect = 0.058, 95 percent CI = 0.030 to 0.091). Targeting dissociative symptoms in the treatment in patients struggling with depression aftermath of traumatic experience could gain a great benefit for recognition and selection of more adequate treatment strategies.
Pregnancy in an isthmocele: A rare case from Nepal
Authors: Tandukar Alina , Aryal Roshan , Khaniya Bishal , Maskey Suvana , Ojha Neebha , Chataut Dinesh 
Published: January 2023

AbstractAn infrequent form of ectopic pregnancy, pregnancy in an isthmocele can be hazardous due to hemorrhage or uterine rupture. With no clear guidelines for the management of this condition, surgery is the preferred option.
Synthesis of PdSn Nanoparticles with a Face‐Centered Cubic Structure for Electrocatalytic Ethanol Oxidation
Authors: Fu Bei , Yang Likang , Xu Luyao , Yang Qingqing , Zheng Yaying , Zhan Tianrong , Guo Peizhi 
Published: January 2023

AbstractOwing to the advantages of large energy density, excellent conversion efficiency, and safety for storage, direct ethanol fuel cells (DEFCs) possess an extensive range of applications in alkaline mediums. In this study, we successfully synthesize the PdSn nanoparticles (NPs) with a different molar ratio of Pd/Sn by a simple one‐step method. The alloyed PdSn NPs present higher electrocatalytic activity and better stability than that of the commercial Pd/C toward ethanol oxidation reaction (EOR). Especially, the PdSn@NP‐2 displayed the best electrocatalytic performance among the as‐prepared samples, the current density for EOR in the alkaline condition of which can even approach 2463.8 mA mg−1, approximately 3.6 times of the commercial Pd/C (700 mA mg−1). Meanwhile, on the base of the electrochemical measurement, it is also observed that increasing temperature and concentrations of KOH/C2H5OH for PdSn NPs positively affect on the current density of the above samples.
Extended q‐Range X‐Ray Scattering Reveals High‐Resolution Structural Details of Biomacromolecules in Aqueous Solutions
Authors: Chen Jiahui , Borkiewicz Olaf J. , Grishaev Alexander V. , Zhang Fan , Bera Mrinal K. , Ruett Uta , Levin Igor 
Published: January 2023

AbstractWe communicate a feasibility study for high‐resolution structural characterization of biomacromolecules in aqueous solution from X‐ray scattering experiments measured over a range of scattering vectors (q) that is approximately two orders of magnitude wider than used previously for such systems. Scattering data with such an extended q‐range enables the recovery of the underlying real‐space atomic pair distribution function, which facilitates structure determination. We demonstrate the potential of this method for biomacromolecules using several types of cyclodextrins (CD) as model systems. We successfully identified deviations of the tilting angles for the glycosidic units in CDs in aqueous solutions relative to their values in the crystalline forms of these molecules. Such level of structural detail is inaccessible from standard small angle scattering measurements. Our results call for further exploration of ultra‐wide‐angle X‐ray scattering measurements for biomacromolecules.
Room Temperature Phosphorescence in Solution from Thiophene‐Bridged Triply Donor‐Substituted Tristriazolotriazines
Authors: Marchi Luciano Hugo , Farias Giliandro , Salla Cristian M. , Franca Larissa G. , Kuila Suman , Monkman Andrew P. , Durola Fabien , Bechtold Ivan H. , Bock Harald , Gallardo Hugo 
Published: January 2023

AbstractMost organic room‐temperature phosphorescence (RTP) emitters do not show their RTP in solution. Here, we incorporated sulfur‐containing thiophene bridges between the donor and acceptor moieties in D3A‐type tristriazolotriazines (TTTs). The thiophene inclusion increased the spin‐orbit coupling associated with the radiative T1→S0 pathway, allowing RTP to be observed in solution for all compounds, likely assisted by protection of the emissive TTT‐thiophene core from the environment by the bulky peripheral donors.
Self‐reported sleep pattern and recurrence of atrial fibrillation after catheter ablation
Authors: Cang Jiehui , Shi Naiyang , Zhu Didi , Liu Yaowu , Zhou Qianxing , Chen Long 
Published: January 2023

AbstractBackgroundIncreasing evidence has shown the relationship between sleep and the recurrence of atrial fibrillation (AF). However, the association of different sleep patterns with AF recurrence after catheter ablation was rarely studied. We aimed to assess the role of different sleep behaviors in the risk of AF recurrence after catheter ablation.Methods and ResultsA total of 416 consecutive participants from Zhongda hospital of Southeast University were finally analyzed. Sleep patterns were defined by chronotype, sleep duration, insomnia, snoring, and daytime sleepiness. A total of 208 patients (50.0%) had a healthy sleep pattern within a mean follow‐up of 32.42 ± 18.18 months. The observed number of patients with AF recurrence was 10 (50.0%), 80 (42.6%), and 40 (19.2%) in unhealthy, intermediate and healthy sleep groups, respectively (p < .01). After adjusting covariates, unhealthy sleep pattern was significantly associated with AF recurrence [hazard ratio = 3.47 (95% confidence interval CI: 1.726–6.979, p < .001)]. Sleep disorders such as inadequate sleep time (time <7 h or >8 h), insomnia and excessive sleepiness during daytime were associated with a higher risk of recurrence. Otherwise, improvement in sleep seemed to be associated with decreased risk of AF recurrence.ConclusionThis retrospective study indicates that adherence to a healthy sleep pattern is associated with a lower risk of AF recurrence. Also, improved sleep before ablation is associated with a lower risk of AF recurrence.
Topography of optic flow processing in olivo‐cerebellar pathways in zebra finches (Taeniopygia guttata)
Authors: Wylie Douglas R. , Gaede Andrea H. , Gutiérrez‐Ibáñez Cristián , Wu Pei‐Hsuan , Pilon Madison C. , Azargoon Sarina , Altshuler Douglas L. 
Published: January 2023

AbstractIn birds, the nucleus of the basal optic root (nBOR) and the nucleus lentiformis mesencephali (LM) are brainstem nuclei involved in the analysis of optic flow. A major projection site of both nBOR and LM is the medial column of the inferior olive (IO), which provides climbing fibers to the vestibulocerebellum. This pathway has been well documented in pigeons, but not other birds. Recent works have highlighted that zebra finches show specializations with respect to optic flow processing, which may be reflected in the organization of optic flow pathways to the IO. In this study, we characterized the organization of these pathways in zebra finches. We found that the medial column consists of at least eight subnuclei (i–viii) visible in Nissl‐stained tissue. Using anterograde traces we found that the projections from LM and nBOR to the IO were bilateral, but heavier to the ipsilateral side, and showed a complementary pattern: LM projected to subnucleus i, whereas nBOR projected to subnuclei ii and v. Using retrograde tracers, we found that these subnuclei (i, ii and v) projected to the vestibulocerebellum (folia IXcd and X), whereas the other subnuclei projected to IXab and the lateral margin of VII and VIII. The nBOR also projected ipsilaterally to the caudo‐medial dorsal lamella of the IO, which the retrograde experiments showed as projecting to the medial margin of VII and VIII. We compare these results with previous studies in other avian species.
Security and storage improvement in distributed cloud data centers by increasing reliability based on particle swarm optimization and artificial immune system algorithms
Authors: Chamkoori Alireza , Katebi Serajdean 
Published: January 2023

SummaryOne of the major concerns in security and storage improvement of data centers is due to the fact that there is a possibility of access to cloud information, and the distance between data centers for data transfer causes cloud storage problems. In this article, an encryption method using artificial immune system (AIS) is leveraged to secure sensitive data in data centers and particle swarm optimization (PSO) algorithm is exploited to improve the selection of storage services in distributed cloud data centers to store and transfer particular a data set between data centers. To obtain satisfied performance considering the transmitting cost, and smallest transmitting distance, we exploited one discrete PSO algorithm and AIS method and called PSO_AIS. To evaluate the proposed PSO_AIS algorithm, we designed the experiments and simulated it in MATLAB software. In the simulation, we conducted experiments on 13 data centers located in different locations in Iran. The experimental results expose that the proposed algorithm reduces 30% the distance and cost to select a particular data center for a particular data set. Experiments have been carried‐out to demonstrate the effectiveness of the proposed encryption method, which is based on AIS. The results showed that the encoding performance of the proposed method is better than other methods.
Trust aware ad hoc routing protocol with key management based mechanism and optimal energy‐efficient cluster head selection in mobile ad hoc networks
Authors: Saravanan S. , Prabakar D. , Sathya S. S. 
Published: January 2023

SummaryThe implementation of Mobile Ad hoc Networks in numerous domains is necessitated by the fast evolving wireless service requirements as well as deployment demands over the last few decades. The application areas are environmental monitoring, disaster rescue operations, military communications, and other safety‐critical sectors. The underlying routing protocol has a considerable impact on the effectiveness of an ad hoc network deployment in a specific situation. MANETs are vulnerable to major security risks that are difficult to combat with current security measures. As a result, several safe routing protocols have been created to improve MANET security. This work proposes a safe and energy‐efficient routing mechanism using group key management. Initially, Particle Swarm Optimization (PSO) was adopted for efficient selection of cluster heads and malicious node detection, which aims to establish the trust among connected nodes that can enhance security as every participating node will produce as well as propagate authentic, accurate, and trusted content within the network. Two specialized nodes, dubbed Calculator Key (CK) and Distribution Key (DK), are then responsible for producing, verifying, and distributing secret keys among nodes employing Asymmetric key cryptography. The proposed method is named Optimal Cluster_ Trust Asymmetric Key Management Protocol (OptCH_TAKMP), which is considered an excellent energy‐efficient cluster head election process with a securable routing mechanism. It is compared with three state‐of‐art methods. Simulation results show that proposed OptCH_TAKMP achieves 31.4% of routing overhead, 23% of end‐to‐end delay, 78.6% of energy efficiency, 94.8% of throughput, 28.2% of average latency, 91.4% of malicious detection rate, and 92.4% of packet delivery ratio, 85.2% of network lifetime, 19.2% of communication cost and 28.6% of trust computation error.
Improving the Catalytic Performance of the Hydrogen Evolution Reaction of α‐MoB2 via Rational Doping by Transition Metal Elements
Authors: Dohnal Filip , Lazar Petr 
Published: January 2023

AbstractAbundant transition metal borides are emerging as promising electrochemical hydrogen evolution reaction (HER) catalysts which have a potential to substitute noble metals. Those containing graphene‐like (flat) boron layers, such as α‐MoB2, are particularly promising and their performance can be further enhanced via doping by the second metal. In order to understand intrinsic effect of doping and rationalize selection of dopants, we employ density functional theory (DFT) calculations to study substitutional doping of α‐MoB2 by transition metals as a route towards systematic improvement of intrinsic catalytic activity towards HER. We calculated thermodynamic stability of various transition metal elements to select metals which form a stable ternary phase with α‐MoB2. We inspected surface stability of dopants and assessed catalytic activity of doped surface through hydrogen binding free energy at various hydrogen coverages. We calculated the reaction barriers and pathways for the Tafel step of HER for the most promising dopants. The results highlight iron as the best dopant, simultaneously lowering the reaction barrier of the Tafel step while having suitable thermodynamic stability within MoB2 lattice.
The impact of social responsibility on corporate financial performance: A systematic literature review
Authors: Coelho Rui , Jayantilal Shital , Ferreira Joao J. 
Published: January 2023

AbstractAlthough corporate social responsibility (CSR) has been gaining relevance in the academic, business, and political worlds, the relationship between CSR and performance remains unclear. This study provides a better understanding of the relationship between companies' financial performance and CSR activities. In other words, can the allocation of company resources to address social, environmental, and governance issues be a source of synergy to increase business value and improve financial performance for the benefit of the company and its stakeholders? To shed new light on this issue, we mapped this topic via a systematic review and content analysis of 53 articles identified in the confluence between CSR and financial performance from 1984 to 2021. Our study suggests that CSR directly impacts a company's financial performance, and this impact becomes more significant as the company's environmental, social, and governance (ESG) scores improve. Moreover, we must note that this is a comprehensive study whose results include analyses of companies from the world's largest stock market indices, mutual funds, sustainable portfolios, non‐sustainable portfolios, regions, asset classes for ESG investing, emerging markets, developed and developing countries, among others. Additionally, this study provides a path for future research.