bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of an anti-inflammatory diet on chronic pain: a pilot study
Authors: Sala-Climent Marta , López de Coca Teresa , Guerrero María Dolores , Muñoz Francisco Javier , López-Ruíz María Amparo , Moreno Lucrecia , Alacreu Mónica , Dea-Ayuela María Auxiliadora 
Published: July 2023

ObjectiveRheumatic diseases result in chronic pain (CP) and require treatment with drugs whose prolonged administration is associated with side effects. However, publications in the academic literature have suggested that diet modification and food supplementation can play a crucial role in alleviating the symptoms of inflammatory disease. Thus, it is hoped that the use of an anti-inflammatory diet for pain management might result in improved quality of life. Hence, here we aimed to investigate the effect of anti-inflammatory foods in patients with CP caused by rheumatic diseases.MethodsAfter an exhaustive bibliography search, we designed a 13-item anti-inflammatory dietary guide based on a Mediterranean diet without red meat, gluten, or cow’s milk (the AnMeD-S). We then conducted a pilot study to evaluate the efficacy of this anti-inflammatory diet in patients with CP. A food consumption score (with a maximum of 156 points) was then applied to evaluate patient adhesion to the proposed diet. Forty-five patients with CP were followed-up for 4 months. Variables related with quality of life (including pain perception, depression status, and sleep satisfaction) were measured using 9 validated questionnaires and anthropometric measurements were recorded before and after the participants followed the anti-inflammatory diet.ResultsWe found a correlation between increased anti-inflammatory food intake and improved physical characteristics, stress, and pain in the patients we assessed. Moreover, decreased consumption of pro-inflammatory foods was positively correlated with sleep satisfaction. Following the AnMeD-S was associated with improved physical characteristics and quality-of-life in patients with CP.ConclusionThe AnMeD-S, includes anti-inflammatory foods and restricts the consumption of certain pro-inflammatory foods (such as those containing gluten). This dietary pattern could provide relief from CP and improve the symptoms of stress and depression, as well as reducing sleep disturbances.
A practical nomogram and risk stratification system predicting the cancer-specific survival for patients aged >50 with advanced melanoma
Authors: Xi Qiufen , Lu Xiaoou , Zhang Jiali , Wang Da , Sun Yu , Chen Hongquan 
Published: July 2023

ObjectiveTo investigate risk factors for advanced melanoma over 50 years of age and to develop and validate a new line chart and classification system.MethodsThe SEER database was screened for patients diagnosed with advanced melanoma from 2010 to 2019 and Cox regression analysis was applied to select variables affecting patient prognosis. The area under curve (AUC), relative operating characteristic curve (ROC), Consistency index (C-index), decision curve analysis (DCA), and survival calibration curves were used to verify the accuracy and utility of the model and to compare it with traditional AJCC tumor staging. The Kaplan-Meier curve was applied to compare the risk stratification between the model and traditional AJCC tumor staging.ResultsA total of 5166 patients were included in the study. Surgery, age, gender, tumor thickness, ulceration, the number of primary melanomas, M stage and N stage were the independent prognostic factors of CSS in patients with advanced melanoma (P&lt;0.05). The predictive nomogram model was constructed and validated. The C-index values obtained from the training and validation cohorts were 0.732 (95%CI: 0.717-0.742) and 0.741 (95%CI: 0.732-0.751). Based on the observation and analysis results of the ROC curve, survival calibration curve, NRI, and IDI, the constructed prognosis model can accurately predict the prognosis of advanced melanoma and performs well in internal verification. The DCA curve verifies the practicability of the model. Compared with the traditional AJCC staging, the risk stratification in the model has a better identification ability for patients in different risk groups.ConclusionThe nomogram of advanced melanoma and the new classification system were successfully established and verified, which can provide a practical tool for individualized clinical management of patients.
Self-compassion and suicide risk: a moderated mediation model and evidence from Chinese universities
Authors: Ge Dandan 
Published: July 2023

IntroductionSuicide is a major social and public health problem in the world. It is important to identify protective and risk factors for suicide. This study aimed to investigate the relationship between self-compassion and suicide risk.Methods1143 college students were surveyed by using Chinese Self-Compassion Scale (CSCS), Depression Anxiety Stress Scale-21 Chinese Version (DASS-21), Connor-Davidson Resilience Scale (CD-RISC), and Suicidal Behaviors Questionnaire-Revised (SBQ-R).ResultsNegative self-compassion had a significant positive predictive effect on college students' suicide risk; in the model of negative self-compassion affecting suicide risk, negative emotions played a mediating role and the mediating role was moderated by resilience. Specifically, compared with low resilience, students with high resilience have a weaker ability to predict suicide risk by negative emotions.DiscussionNegative self-compassion is a risk factor for suicide risk, reducing negative self-compassion (self-judgment, isolation, and over-identification) and enhancing resilience has a guiding effect on suicide prevention and intervention.
The association between adherence to diet quality index and cardiometabolic risk factors in overweight and obese women: a cross-sectional study
Authors: Mohamadi Azam , Shiraseb Farideh , Mirzababaei Atieh , AkbarySedigh Assa , Ghorbani Moloud , Clark Cain C. T. , Aali Yasaman , Mirzaei Khadijeh 
Published: July 2023

BackgroundObesity and overweight status increase the risk of cardiovascular disease. Diet quality can also predict the risk of cardiovascular diseases in obese and overweight patients. Therefore, in this study, we sought to examine the relationship between diet quality index (DQI) and cardiometabolic risk factors in obese and overweight women.MethodA cross-sectional study was conducted on 197 Iranian women with a Body Mass Index (BMI) &gt; 25, 18–48 years, and recruited from 20 Tehran Health Centers. Nutrition intake and DQI were assessed using a 147-item semi-quantitative food frequency questionnaire (FFQ). Additionally, anthropometric measurements, body composition, biochemical evaluations, and cardiometabolic risk factors were evaluated.ResultsThere was an association between DQI and waist-to-hip ratio (WHR), atherogenic index of plasma (AIP), and CHOLINDEX in obese women, after adjusting for potential confounders. Whereas, there were no significant associations of the tertiles of DQI compared with the first tertile in other cardiometabolic risk factors, before and after adjustment.ConclusionThis study provides evidence that dietary intake and DQI are associated with cardiometabolic risk factors and that dietary modification may be a predictor for reducing WHR, AIP, and CHOLINDEX. However, more research is needed to develop a DQI that reflects changes in cardiometabolic risk factors by considering women's eating habits and patterns.
Safety reporting of Essure medical device: a qualitative and quantitative assessment on the FDA manufacturer and user facility device experience database in 2018
Authors: Zou Chenyu , Davis Brandy , Wigle Patricia R. , Hincapie Ana L. , Guo Jeff Jianfei 
Published: July 2023

BackgroundThere have been numerous cases of adverse events since the introduction of Essure medical devices for sterilization in 2002. This study analyzed the safety event reports of the Essure reported in the Manufacturer and User Facility Device Experience (MAUDE).MethodsA retrospective analysis examined the MAUDE reports between Jan-1, 2018, and Oct-31, 2018 and focused on safety reports related to the Essure device. Safety reports were categorized and analyzed by their event type, device problem, patients’ symptoms and the level of harm. Of this study cohort, 10% of samples were randomly selected for quantitative analyses. Thematic analysis was conducted for reports included death cases.ResultsA total of 4,994 eligible reports were analyzed. There were ten reports associated with individuals’ deaths, and the main themes of safety reports from qualitative analysis were pains, bleeding, surgery, migraine, and infection. Quantitative analysis of 500 randomly selected samples showed that 98% of adverse event reports were associated with different injuries such as surgery, pain, bleeding, hysterectomy, and menorrhagia. Additionally, more than 90% of reports were submitted by the manufacturer.ConclusionThese findings indicated several safety issues of Essure. More meaningful pre- and post-marketing surveillance and regulation are warranted in the medical device market to ensure safety and effectiveness, including investigating complaints, promptly sharing relevant information with regulators and users, and implementing corrective actions
Does meaningful work mediate the relationship between empowering leadership and mental health? Evidence from Malaysian SME employees
Authors: Jalil Muhammad Farhan , Tariq Bilal , Ali Azlan 
Published: July 2023

IntroductionIn Malaysia, small and medium enterprises (SMEs) account for more than half of all employment and 98.7% of all businesses. There is little research on empowering behaviors in SMEs, despite leadership empowerment being often practiced. Therefore, the study aims to investigate how empowering leadership affects employees' mental health. The study also reveals meaningful work's role in mediating the relationship between empowering leadership and employees' mental health.MethodsA stratified random sample approach was used to collect data from 516 employees of Malaysian SMEs. The data was analyzed, and the hypothesis was tested using structural equation modeling (AMOS 21.0) with bootstrap confidence intervals computed to evaluate the mediating effect.ResultsThe results demonstrate that empowering leadership significantly improves employees' mental health. Furthermore, the association between empowering leadership and mental health is partially mediated by meaningful work.DiscussionThis study contributes to the present empowering leadership-meaningful work-mental health model for SME employees, which reduces stress and anxiety at the workplace and positively impacts psychological empowerment and their capacity to control their overall emotions in instances of success.
A randomized controlled study of a psycho-behavioral intervention combined with a non-benzodiazepine to improve perioperative sleep quality in patients undergoing knee arthroplasty
Authors: Jing Wang , Chunlin Zhao , Xue Yang , Tingting He , Linyan Yuan , Xiao Chen , Lingli Li 
Published: July 2023

ObjectiveTo clarify the effectiveness and safety of psycho-behavioral intervention combined with a non-benzodiazepine to improve perioperative sleep quality in patients undergoing knee arthroplasty, and also to explore the optimal dosage of non-benzodiazepine (oral zolpidem tartrate) to form a standardized sleep quality management process to promote accelerated recovery of patients.Methods240 patients undergoing initial unilateral total knee arthroplasty between January and December 2016 were prospectively included and randomly divided into blank control group (group A), psycho-behavioral intervention group (group B), zolpidem tartrate 10 mg group (group C), and psycho-behavioral intervention + zolpidem tartrate 5 mg group (group D). Sleep, pain, psychological, and knee function scores were compared.ResultsThere were significant differences between the four groups with respect to Pittsburgh sleep quality index scores, sleep efficiency, Epworth Sleepiness Scale scores, inflammatory indices, pain, and enhanced recovery after surgery indices during hospitalization (P &lt; 0.05).ConclusionPsychological behavioral intervention combined with non-benzodiazepine can improve the perioperative quality of sleep. Compared with drug intervention alone, it reduces the dosage of non-benzodiazepine, alleviates anxiety, improves patient satisfaction, and enhances the quality of life.
Intensive neurorehabilitation and allogeneic stem cells transplantation in canine degenerative myelopathy
Authors: Gouveia Débora , Correia Jéssica , Cardoso Ana , Carvalho Carla , Oliveira Ana Catarina , Almeida António , Gamboa Óscar , Ribeiro Lénio , Branquinho Mariana , Sousa Ana , Lopes Bruna , Sousa Patrícia , Moreira Alícia , Coelho André , Rêma Alexandra , Alvites Rui , Ferreira António , Maurício Ana Colette , Martins Ângela 
Published: July 2023

IntroductionDegenerative myelopathy (DM) is a neurodegenerative spinal cord disease with upper motor neurons, with progressive and chronic clinical signs, similar to amyotrophic lateral sclerosis (ALS). DM has a complex etiology mainly associated with SOD1 gene mutation and its toxic role, with no specific treatment. Daily intensive rehabilitation showed survival time near 8 months but most animals are euthanized 6–12 months after clinical signs onset.MethodsThis prospective controlled blinded cohort clinical study aims to evaluate the neural regeneration response ability of DM dogs subjected to an intensive neurorehabilitation protocol with mesenchymal stem cells (MSCs) transplantation. In total, 13 non-ambulatory (OFS 6 or 8) dogs with homozygous genotype DM/DM and diagnosed by exclusion were included. All were allocated to the intensive neurorehabilitation with MSCs protocol (INSCP) group (n = 8) or to the ambulatory rehabilitation protocol (ARP) group (n = 5), which differ in regard to training intensity, modalities frequency, and MSCs transplantation. The INSCP group was hospitalized for 1 month (T0 to T1), followed by MSCs transplantation (T1) and a second month (T2), whereas the ARP group was under ambulatory treatment for the same 2 months.ResultsSurvival mean time of total population was 375 days, with 438 days for the INSCP group and 274 for the ARP group, with a marked difference on the Kaplan–Meier survival analysis. When comparing the literature's results, there was also a clear difference in the one-sample t-test (p = 0.013) with an increase in time of approximately 70%. OFS classifications between groups at each time point were significantly different (p = 0.008) by the one-way ANOVA and the independent sample t-test.DiscussionThis INSCP showed to be safe, feasible, and a possibility for a long progression of DM dogs with quality of life and functional improvement. This study should be continued.
The Independent Effects of Kidney Length and Vascular Plaque on Ten-Year Outcomes of Extended Criteria Donor Kidney Transplants
Authors: Tanriover Bekir , Stewart Darren , Kamal Layla , Saeed Muhammad , Cooper Matthew , Foutz Julia , McGehee Harrison , Gupta Gaurav 
Published: July 2023

The independent effects of deceased donor kidney length and vascular plaque on long-term graft survival are not established. Utilizing DonorNet attachments from 4,480 expanded criteria donors (ECD) recovered between 2008 and 2012 in the United States with at least one kidney biopsied and transplanted, we analyzed the relationship between kidney length and vascular plaques and 10-year hazard of all-cause graft failure (ACGF) using causal inference methods in a Cox regression framework. The composite plaque score (range 0–4) and the presence of any plaque (yes, no) was also analyzed. Kidney length was modeled both categorically (&lt;10, 10–12, &gt;12 cm) as well as numerically, using a restricted cubic spline to capture nonlinearity. Effects of a novel composite plaque score 4 vs. 0 (HR 1.08; 95% CI: 0.96, 1.23) and the presence of any vascular plaque (HR 1.08; 95% CI: 0.98, 1.20) were attenuated after adjustment. Likewise, we identified a potential nonlinear relationship between kidney length and the 10-year hazard of ACGF, however the strength of the relationship was attenuated after adjusting for other donor factors. The independent effects of vascular plaque and kidney length on long-term ECD graft survival were found to be minimal and should not play a significant role in utilization.
Limosilactobacillus fermentum MG5091 and Lactococcus lactis MG4668 and MG5474 Suppress Muscle Atrophy by Regulating Apoptosis in C2C12 Cells
Authors: Park Jeong-Yong , Lee Ji Yeon , Kim YongGyeong , Kang Chang-Ho 
Published: July 2023

Muscular atrophy is a chronic muscle disease characterized by a loss of muscle mass and muscle weakness due to excessive protein breakdown relative to protein synthesis. Apoptosis is a major factor in sarcopenia and the final stage of muscle atrophy that occurs via various mechanisms. In this study, we evaluated the protective effects of cell-free supernatants (CFSs) from different lactic acid bacteria (LAB) strains in dexamethasone (DEX)-treated C2C12 cells, followed by probiotic properties. We found that Limosilactobacillus fermentum (L. fermentum) MG4263 and MG5091 and Lactococcus lactis (Lc. lactis) MG4668 and MG5474 inhibited muscle atrophy F-box (atrogin-1) and muscle-specific RING-finger protein-1 (MuRF-1) in DEX-treated C2C12 cells. In addition, LAB strains inhibited the expression of apoptotic proteins, such as Bcl-2-associated X (Bax)/Bcl-2 and caspase-3 in DEX-treated C2C12 cells. L. fermentum MG5091, Lc. lactis MG4668, and MG5474 showed high survival rates in gastrointestinal (GIT) conditions and high adhesion rate to HT-29 cells. The LAB strains were also assessed for hemolysis and toxicity in HT-29 cells to confirm their stability. The LAB strains showed no hemolytic activity and toxicity to HT-29 cells. Therefore, L. fermentum MG5091, Lc. lactis MG4668, and MG5474 suggest their potential as probiotics to be used as functional foods for the inhibition of muscular atrophy.
Team-based continuity of care for patients with hypertension: a retrospective primary care cohort study in Hong Kong
Authors: Xu Wanchun , Yu Esther Yee Tak , Chin Weng Yee , Mak Ivy Lynn , Chan Cheyenne I Ying , Lam Cindy Lo Kuen , Wan Eric Yuk Fai 
Published: July 2023

BackgroundContinuity of care (COC) is associated with improved health outcomes in patients with hypertension. Team-based COC allows more flexibility in service delivery but there is a lack of research on its effectiveness for patients with hypertension.AimTo investigate the effectiveness of team-based COC on the prevention of cardiovascular disease (CVD) and mortality in patients with hypertension.Design and settingA retrospective cohort study in a primary care setting in Hong Kong.MethodEligible patients included those visiting public primary care clinics in Hong Kong from 2008 to 2018. The usual provider continuity index (UPCI) was used to measure the COC provided by the most visited physician team. Cox regression and restricted cubic splines were applied to model the association between the COC and the risk for CVDs and all-cause mortality.ResultsThis study included 421 640 eligible patients. Compared with participants in the lowest quartile of UPCI, the hazard ratios for overall CVD were 0.94 (95% CI = 0.92 to 0.96), 0.91(95% CI = 0.89 to 0.93), and 0.90 (95% CI = 0.88 to 0.92) in the second, third, and fourth quartiles, respectively. A greater effect size on CVD risk reduction was observed among the patients with unsatisfactory blood pressure control, patients aged <65 years, and those with a Charlson comorbidity index of <4 at baseline (Pinteraction<0.05 in these subgroup analyses), but the effect was insignificant among the participants with an estimated glomerular filtration rate of <60 ml/ min/1.73 m2at baseline.ConclusionTeam-based COC via a coordinated physician team was associated with reduced risks of CVD and all-cause mortality among patients with hypertension, especially for the patients with unsatisfactory blood pressure control. Early initiation of team-based COC may also achieve extra benefits.
PEMERIKSAAN GOLONGAN DARAH ABO MENGGUNAKAN HOMEMADE ANTISERA SERUM DAN PLASMA
Authors: Abror Yogi 
Published: July 2023

Golongan darah ditentukan oleh adanya Antigen yang berada di permukaan sel eritrosit. Pemeriksaan golongan darah sistem ABO yang paling sering digunakan adalah metode slide menggunakan reagen antisera. Pada umumnya yang digunakam adalah antisera komersial dengan harga yang relatif mahal. Penelitian ini bertujuan untuk membuat Homemade antisera yang lebih terjangkau dari bahan serum dan plasma serta membandingkan hasilnya dengan reagen komersial. Penelitian ini merupakan eksperimen dengan desain static group comparison. Sampel berjumlah 55 dengan kategori golongan darah A sebanyak 12, golongan darah B sebanyak 13, golongan darah AB sebanyak 5 dan golongan darah O sebanyak 25. Sampel kemudian dilakukan pemeriksaan golongan darah ABO menggunakan antisera komersial dan Homemade antisera lalu dibandingkan hasilnya. Analisis data secara statistik pada penelitian menggunakan uji friedman. Hasil dari analisis uji friedman diperoleh nilai signifikansi golongan darah A > 0.05 yaitu 1,000, nilai signifikansi golongan darah B > 0.05 yaitu 1,000, nilai signifikansi golongan darah AB > 0.05 yaitu 1,002 dan nilai signifikansi golongan darah O > 0.05 yaitu 1,000. Berdasarkan hasil statistik tersebut dapat disimpulkan tidak terdapat perbedaan hasil secara signifikan pada pemeriksaan golongan darah ABO menggunakan reagen antisera komersial dan homemade antisera dari serum dan plasma A, B dan O.
AKTIFITAS FISIK TERPROGRAM EFEKTIF DALAM MENINGKATKAN FUNGSI KOGNITIF USIA LANJUT
Authors: Supriadi Supriadi , Washudi Washudi 
Published: July 2023

Meningkatnya proporsi usia lanjut, menimbulkan beberapa masalah kesehatan pada usia lanjut. Masalah kesehatan terbesar adalah penyakit degeneratif. Diperkirakan pada tahun 2050 sekitar 75% usia lanjut menderita penyakit degeneratif dan tidak dapat beraktivitas. Salah satu gangguan akibat proses degeneratif tersebut adalah penurunan fungsi kognitif. Penelitian bertujuan mengetahui pengaruh aktifitas fisik terprogram terhadap peningkatan fungsi kognitif pada usia lanjut. Desain penelitian ini adalah quasi-experimental dengan pendekatan pre-test and post-test with control group. Sampel penelitian sebesar 15 orang untuk subjek perlakuan, dan 15 orang untuk kontrol, dengan kriteria: usia 60 – 70 tahun, mampu berkomunikasi secara verbal maupun non verbal, dan keadaan umum baik/normal. Instrumen yang digunakan untuk mengukur fungsi kognitif dengan Mini Mental State Examination (MMSE). Terhadap sampel diberikan intervensi latihan aktifitas fisik secara terprogram selama satu bulan, dan dilakukan pengukuran fungsi kognitif sebelum dan setelah intervensi. Analisis data dilakukan melalui analisis univariat dengan mean dan analisis bivariat dengan uji t. Hasil penelitian menunjukan fungsi kognitif pada usia lanjut sebelum dan sesuah melakukan aktifitas fisik terprogram mengalami kenaikan dari rerata skor 24,67 menjadi 26,53 dengan peningkatan skor 1,86, p-value 0.000, artinya bahwa aktifitas fisik terprogram efektif dalam meningkatkan fungsi kognitif pada usia lanjut.