bluuebunny/crossref_metadata_2025_split huggingface dataset:
OXIDATIVE ADDITION‐REDUCTIVE ELIMINATION SUPPORTED BY A LIGAND‐ELEMENT COOPERATION AT THE ARSINIDENE AND STIBINIDENE CENTER
Authors: Kremlacek Vit , Kertesz Erik , Erben Milan , Ruzicka Ales , Jambor Roman , Benko Zoltan , Dostál Libor 
Published: February 2025

The treatment of pnictinidenes [2‐(RNHCH2)‐6‐(RN=CH)C6H3]E (1As/Sb) (where E = As or Sb) with benzoyl peroxide provided compounds [2‐(DippNCH2)‐6‐(DippN=CH)C6H3]E(O2CPh) (2As/Sb) as a result of two step procedure, i.e. oxidation of the pnictogen centre followed by the elimination of benzoic acid. The reaction between 1As and diphenyl disulfide proceeded in the same vein yielding thiophenol and [2‐(DippNCH2)‐6‐(DippN=CH)C6H3]As(SPh) (3As). Analogous reaction of 1Sb furnished a mixture of [2‐(DippNHCH2)‐6‐(DippN=CH)C6H3]Sb(SPh)2 (3´Sb), [2‐(DippNCH2)‐6‐(DippN=CH)C6H3]Sb(SPh) (3Sb) and PhSH, while NMR studies proved the existence of a dynamic equilibrium between all three compounds in solution and removal of incipient PhSH was necessary for the isolation of 3Sb. Both 1As/Sb smoothly reacted with 2‐nitrosotoluene leading to [2‐(DippNCH2)‐6‐(DippN=CH)C6H3]E(O‐NH‐2‐Me‐Ph) 4As/Sb and with 4‐phenyl‐1,2,4‐triazoline‐3,5‐dione giving [2‐(DippNCH2)‐6‐(DippN=CH)C6H3]E[(N(CO)‐NH(CO))N‐Ph] 5As/Sb. All compounds were characterized by IR, Raman, NMR spectroscopy, and the molecular structures, except for 3As and 5Sb, were determined by single‐crystal X‐ray diffraction. Furthermore, we scrutinized the thermally induced reductive elimination of benzoic acid and thiophenol from 2‐3As/Sb, respectively, and that of 4‐phenylurazole from 5As. These eliminations involve C‐H activation at the CH2N group, and the recovery of the pnictinidene center in [2,6‐(RN=CH)2C6H3]E (6As/Sb). Using DFT calculations a plausible mechanism was suggested for all investigated reactions, which are in good agreement with the experimental observations.
Computation‐Guided Regulation of Thiophene‐Based Covalent Organic Frameworks for Boosting Photocatalytic Hydrogen Evolution†
Authors: Luo Xiao , Chen Yuxiang , Lin Jia‐Tong , Luo Jie , Xia Ri‐Qin , Yin Na , Lin Yang‐Min , Duan Haiyan , Ren Shi‐Bin , Gao Qiang , Ning Guo‐Hong , Li Dan 
Published: February 2025

Comprehensive SummaryCompared to the conventional trial‐and‐error approach, computational prediction is becoming an increasingly prominent approach in the discovery of covalent organic frameworks (COFs) with specific applications, yet it has been rarely demonstrated. Herein, we employed density functional theory (DFT) to pre‐screen the electronic and optical properties of thiophene‐based donor‐acceptor (D‐A) pairs simplified from their corresponding COF structures. Theoretical calculation illustrates the BMTB‐BTTC with the highest number of thiophene units is expected to exhibit the best photocatalytic performance for hydrogen production. According to calculation prediction, four COFs have been prepared and their photocatalytic activities have been experimentally validated. Interestingly, the corresponding BMTB‐BTTC‐COF shows the highest photocatalytic hydrogen production rate of 12.37 mmol·g–1·h–1 among the four COFs. Combining the calculation and experimental results, it has been proven that the photocatalytic activity can be fine‐tuned by modulating the number of thiophene units. Our study provides a new strategy for the rational design and regulation of D‐A COFs to enhance photocatalytic activity through computational prediction.
SLIC‐SABRE at Microtesla Fields Enables High Levels of Nuclear Spin Polarization Without Magnetic Shielding
Authors: Kozinenko Vitaly P. , Kiryutin Alexey S. , Yurkovskaya Alexandra V. 
Published: February 2025

AbstractEmploying nuclear spin hyperpolarization to enhance NMR sensitivity opens new horizons for metabolic studies and chemical reaction monitoring. Among the hyperpolarization techniques, Signal Amplification by Reversible Exchange (SABRE) is prominent for its ability to transfer spin order from parahydrogen to target nuclei, especially 13C and 15N, without the chemical modification of the substrate under study. Despite its power, existing implementations of SABRE require expensive equipment like radiofrequency (RF) hardware and magnetic shielding. This paper demonstrates the SLIC‐SABRE (Spin Lock Induced Crossing SABRE) method at low magnetic fields as a low‐cost and efficient technique for achieving high 15N polarization using a simple setup, consisting only of a small set of magnetic coils driven by a desktop PC sound card. The method yields from 5 up to 17 % polarization across various SABRE‐active molecules, outperforming the conventional SABRE‐SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) approach and significantly enhancing the accessibility of hyperpolarization techniques.
A Comprehensive Review of the Research Progress on the Low‐Temperature Performance of LiFePO4 Batteries
Authors: Tang Rui , Dong Jinyang , Wang Chengzhi , Yin Aining , Lu Yun , Li Ning , Shen Wenjun , Zhang Jinhua , Yan Kang , Zhao Guangjin , Li Bowen , Wang Xi , Xu Yuelei , Wu Feng , Su Yuefeng , Chen Lai 
Published: February 2025

ABSTRACTLithium iron phosphate (LiFePO4) serves as a commonly used cathode material in lithium‐ion batteries and is an essential power source for consumer electronics and electric vehicles. Nevertheless, significant degradation in its electrochemical performance occurs at low temperatures, leading to energy and power losses, challenges in charging, a reduced lifespan, and heightened safety concerns—critical factors for LiFePO4 applications. This review outlines recent progress aimed at enhancing the low‐temperature performance of LiFePO4 batteries, concentrating on the mechanisms involved in various modification strategies. The primary factors contributing to the reduced performance of LiFePO4 at subzero temperatures are first examined. A variety of strategies designed to improve the interfacial and internal electrochemical reaction kinetics of LiFePO4 cathodes under cold conditions are emphasized, and feasible approaches to improve low‐temperature kinetics are also presented. These include optimizing cell design to enhance inherent reactivity and employing heating techniques to raise external reaction temperatures. In conclusion, this review discusses the challenges and limitations associated with LiFePO4 batteries in low‐temperature settings and examines advancements in low‐temperature lithium‐ion batteries from the cell to the system level. The insights provided are intended to motivate further developments in lithium‐ion batteries and other technologies tailored for subzero applications.
Oxygen saturation imaging elucidates tumor heterogeneity in gastric cancer
Authors: Minamide Tatsunori , Minakata Nobuhisa , Yamashita Riu , Sakashita Shingo , Yoda Yusuke , Ohashi Akihiro , Aoshima Masato , Kobayashi Susumu , Yano Tomonori 
Published: February 2025

AbstractOxygen saturation imaging is a new technology that determines biological features from the perspective of oxygen concentration. Therefore, this exploratory study aimed to evaluate the biological implications of oxygen saturation imaging and further assess tumor heterogeneity in gastric cancer. Biopsy samples were selectively obtained from treatment‐naïve patients with gastric cancer under real‐time oxygen saturation imaging. Tissue oxygen saturation level calculations, immunohistochemistry, and RNA sequencing were performed. The mean tissue oxygen saturation levels at the sampling sites were 32.2%, 70.8%, and 56.2% for hypoxic, hyperoxic, and non‐tumor areas, respectively, with significant differences between each pair. CD‐31 and glucose transporter 1 protein expression were significantly upregulated in hypoxic tumors. Comprehensive transcriptomic analysis revealed enriched biological processes related to the regulation of insulin‐like growth factor transport and uptake by insulin‐like growth factor‐binding proteins in hypoxic tumors and the type I interferon signaling pathway in hyperoxic tumors. Oxygen saturation imaging has the potential to clarify hypoxia‐induced heterogeneity in gastric cancer from both clinical and fundamental perspectives.
A case of recurrent gastric volvulus successfully treated with nasogastric tube‐assisted endoscopic reduction and percutaneous endoscopy‐assisted gastropexy
Authors: Katoh Ryuji , Katoh Eriko , Tatsuki Hironori , Saito Fumiyoshi , Motegi Masahiko , Osawa Kiyotaka , Saeki Hiroshi 
Published: February 2025

AbstractWe report the case of a 97‐year‐old male with recurrent gastric volvulus who was successfully treated with nasogastric tube‐assisted endoscopic reduction followed by percutaneous endoscopy‐assisted gastropexy with gastric wall fixation. The nasogastric tube facilitates endoscopic reduction by enhancing the procedure's efficiency. In contrast, percutaneous endoscopy‐assisted gastropexy provides an effective, minimally invasive method to prevent the recurrence of gastric volvulus, even in patients with poor overall health. This case highlights the clinical utility of these combined approaches in managing gastric volvulus in elderly patients with significant comorbidities.
Identification of Hexahydrocannabiphorol Metabolites in Human Urine
Authors: Schirmer Willi , Schürch Stefan , Weinmann Wolfgang 
Published: February 2025

ABSTRACTHexahydrocannabiphorol (HHCP) is an emerging semisynthetic cannabinoid, which has been known since 1942 from research of tetrahydrocannabinol (THC) analogs and homologs. After the ban of hexahydrocannabinol (HHC) in many European Countries HHCP emerged as a replacement among other similar compounds. First countries already placed HHCP under their narcotic substance law. The aim of this research was to identify human Phase I and II metabolites in urine after oral HHCP consumption. Enzymatic immunoassays of urine samples were tested negative for cannabinoids after a single oral consumption of 4‐mg HHCP from a Δ9‐THC abstinent volunteer. The HHCP sample consumed in the self‐experiment was purchased from an online store and analyzed beforehand using GC–MS. LC–HR‐MS/MS and GC–MS after derivatization were used for the identification of metabolites. Hydroxylated metabolites were found with hydroxylation on the side chain or on the alicyclic part of the molecule. Bishydroxylated HHCP metabolites were found in similar abundance as the monohydroxy metabolites. All of the bishydroxylated metabolites besides a minor metabolite had a hydroxyl group on the side chain and another hydroxyl group on the alicyclic part of the molecule. In addition, the corresponding glucuronides were identified by LC–HR‐MS/MS. The exact positions and stereochemistry of the hydroxylation sites could not be determined. Due to the extensive metabolism of HHCP and the lacking cross‐reactivity of urine samples after consumption in Δ9‐THC specific immunoassays, it is recommended to include HHCP metabolites in routine screening methods. Monohydroxylated and bishydroxylated metabolites of HHCP and their respective glucuronides are suggested as forensic targets.
Socialisation of Emotion Regulation in Preschool Classrooms: How Do Peers Matter?
Authors: Diebold Tatiana , Jaggy Ann‐Kathrin , Perren Sonja 
Published: February 2025

ABSTRACTThe development of emotional competence is an important milestone during early childhood. Beyond early experience within the family, the (preschool) classroom is a relevant socialisation context, and both teachers and peers may contribute to children's emotion‐related outcomes. Tracking changes in the emotion regulation competence of N = 173 preschool children (age in months: M = 43.3, SD = 6.6, 45% girls) over 6 months, the current study investigated whether and how peers contribute to differences in the development of emotion regulation in preschool classrooms. The research questions were addressed by examining three different kinds of peer groups: Classroom‐level peer group, friendship group, and high‐status peers (social network centrality). Teachers rated children's emotion regulation competence and empathic co‐regulation behaviour—referring to preschoolers' supportive responses to their peers' emotional expressions—at three assessment points. Multilevel growth modelling provided evidence that friendship‐group empathic co‐regulation (empathy, helping, and comforting behaviour) predicted changes in preschoolers' emotion regulation over time, confirming that friendship groups influence young children's emotional development.
The Impact of Maternal Diabetes Mellitus on Fetal Corpus Callosum Morphology: A Case–Control Study
Authors: Özdal Burcu Bozkurt , Tanaçan Atakan , Özkavak Onur , Kara Özgür , Şahin Dilek 
Published: February 2025

ABSTRACTObjectiveTo investigate the morphology of the corpus callosum (CC) in fetuses of pregnant women with diabetes.Materials and MethodsThis prospective study was conducted between February 2024 and August 2024 at a tertiary hospital and included a total of 81 pregnant women, divided into three groups: 27 with gestational diabetes (GDM), 27 with pregestational diabetes (PGDM), and 27 controls. For each patient, CC and cavum septum pellucidum (CSP) measurements, tela‐choroidea‐to‐anterior‐cerebral‐artery distance (TACAD), and Doppler parameters of the anterior cerebral artery were examined.ResultsThe mean CC length significantly differed among the three groups (p = 0.00). Post hoc Tukey analysis showed a significant difference between the control group and the PGDM group (p = 0.001), as well as between the control group and the GDM group (p = 0.002). No significant differences were found among the three groups in terms of CC width, TACAD, anterior cerebral artery Doppler parameters, or CSP width and length (p > 0.05). The CC/head circumference ratio was significantly different among the three groups (p = 0.000).ConclusionWe found that fetal CC morphology was affected in pregnancies presenting with GDM and PGDM, likely due to increased transplacental transfer of nutrients caused by maternal hyperglycemia, which accelerates fetal growth.
Impact of Radiofrequency and Microwave Heating on the Nutritional and Antinutritional Properties of Pulses: A Review
Authors: Das Pabitra Chandra , Baik Oon‐Doo , Tabil Lope G. , Rajagopalan Nandhakishore 
Published: February 2025

ABSTRACTPulses, which are the dry seeds of legume crops, have gained global popularity, leading to a notable rise in their production. They are rich in protein, minerals, fibers, and low in fat content. However, they have some antinutrients that need to be removed. Novel techniques like radiofrequency (RF) and microwave (MW) heating can enhance pulse quality by reducing the antinutrients. The key mechanism behind this improvement is the rapid heating that disrupts the native structure of the pulses. These technologies offer several advantages, including speed, consistency, sustainability, and energy efficiency. The effectiveness of RF and MW processing depends on the heating conditions used and the kind of pulses being treated. This review highlights the mechanisms and influencing factors of RF and MW heating as well as their effect on the nutritional and antinutritional qualities of various pulses. Additionally, the limitations of these technologies are summarized, and future research prospects focusing on pulse processing are identified.
A Study on the Co‐Opetition Game Between Low‐Carbon Supply Chains Under Carbon Cap‐and‐Trade Policy
Authors: Li Fang , Yang Yijing , Zhang Wenmin , Li Jiajia 
Published: February 2025

ABSTRACTTwo competing low‐carbon supply chains are modeled using a Nash game and a manufacturer‐dominated Stackelberg game. This study explores equilibrium decisions and profit changes under six competitive models within a carbon cap‐and‐trade policy, focusing on low‐carbon competition and cost reduction. The results indicate that although carbon quotas provide economic benefits, they do not drive emission reductions. Higher carbon trading prices incentivize reductions. Vertical cooperation and horizontal competition improve emission rates and reduce retail prices, whereas horizontal cooperation can harm profits. Optimal outcomes require enhanced collaboration within supply chains and government regulation of carbon trading prices to balance emissions reductions and profits.
Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double‐Blind Trial
Authors: Santamarina Aline Boveto , Filho Victor Nehmi , de Freitas Jéssica Alves , Franco Lucas Augusto Moysés , Martins Roberta Cristina , Fonseca Joyce Vanessa , Orellana Turri José Antônio , Hufnagel Mariana Tedesco , Demarque Daniel Pecoraro , da Silva Bruna Fernanda Rio Branco , Gusmão Arianne Fagotti , Olivieri Eloísa Helena Ribeiro , de Souza Erica , de Souza Esther Alves , Otoch José Pinhata , Pessoa Ana Flávia Marçal 
Published: February 2025

ABSTRACTThis study explores the effects of a nutraceutical blend with prebiotics, β‐glucans, essential minerals, and silymarin on gut microbiota, inflammation, and sleep quality in obesity through microbiota reshaping and metabolic improvements over 90 days. A double‐blind, randomized trial was conducted on 77 participants divided into two groups receiving either a standard nutraceutical blend (NSupple) or a silymarin‐enriched blend (NSupple_Silybum). Fecal and plasma samples were collected at baseline and post‐supplementation for gut microbiota, metabolic, and inflammatory marker analysis. The results showed a reduction in body weight, waist‐to‐height ratio, total cholesterol, and fractions in the NSupple_Silybum group. There was a dysbiosis recovery shown by the increase in beneficial gut bacteria, such as Lentisphaerae phylum, Lactobacillus and Faecalibacterium genera, and Faecalibacterium prausnitzii in the NSupple group, with a concurrent reduction in Adlercreutzia and Sutterella in the NSupple_Silybum group. Both groups demonstrated improved inflammatory profiles by the reduced TNF‐α/IL‐10 ratio, reduced cortisol levels, and reduced Firmicutes/Bacteroides ratio. Additionally, improvements in sleep quality were associated with reductions in pro‐inflammatory cytokines and improved microbiota composition. The nutraceutical blend reshaped gut microbiota, enhanced anti‐inflammatory species, and improved metabolic and sleep parameters, highlighting its potential as a nutritional strategy for managing obesity and reducing inflammation.
Utilization of Pulsed Current‐Electro Fenton Technology for the Treatment of Wastewater from Industrial Processes
Authors: Asaithambi Perumal , Ezzat Abdelrahman O. , Bidira Firomsa , Busier Yesuf Mamuye , Abd‐Elkader Omar H. , Thirumurugan Arun , Hariharan N. M. , Al‐Lohedan Hamad A. , Kadier Abudukeremu 
Published: February 2025

AbstractIn recent years, there has been a rise in the use of electrochemical and advanced oxidation methods to treat the industrial wastewater. The efficiency of several approaches for treating industrial wastewater, including hydrogen peroxide (H2O2), electro–Fenton (EF) and pulsed–electro–Fenton (PEF) processes were all investigated. In evaluation to the H2O2, EF, and PEF technologies, the results showed that the PEF process produced 100 % total color and 98 % chemcial oxygen demand (COD) removal efficiency with a low consumption of power of 3.4 kWhrm−3. The experimental parameters comprised the following: COD – 2500 mg L−1, pH – 3, H2O2 – 300 mg L−1, distance between electrode – 0.75 cm, current – 0.40 A, cycle of pulse duty – 0.75, combination of electrode – Fe/Fe, stirring speed – 500 rpm and treatment duration (TD) – 125 min. It was demonstrated that increasing the TD, current, and H2O2 while lowering the COD content improved the COD elimination efficiency while employing a iron (Fe/Fe) electrode combination with wastewater pH of 3. The efficiency of the EF process has been reduced in comparison to the PEF process because of the development of an impermeable oxide layer on the cathode and the oxidation–induced corrosion on the anode. Consequently, experimental results have indicated that the PEF could be a more promising technology than the EF method for eliminating pollutants from wastewater with reduced power consumption and process efficiency.
Progression of Otologic and Nasal Symptoms in Primary Ciliary Dyskinesia Throughout Childhood
Authors: Dagher Isabelle , Kimple Adam J. , Ferkol Thomas W. , Sagel Scott D. , Dell Sharon D. , Milla Carlos E. , Li Lang , Lin Feng‐Chang , Sullivan Kelli M. , Zariwala Maimoona A. , Knowles Michael R. , Rosenfeld Margaret , Leigh Margaret W. , Davis Stephanie D. ,   for the Genetic Disorders of Mucociliary Clearance Consortium
Published: February 2025

AbstractObjectivePrimary ciliary dyskinesia (PCD) is characterized by upper and lower airway disease. Multiple studies have demonstrated the progression of pulmonary disease; however, longitudinal changes in the otologic and nasal symptoms have not been well described in patients. This study defines age‐related prevalence, age of onset, and age‐related trends in self‐reported otologic and sinonasal comorbidities in individuals with PCD.Study DesignA prospective, longitudinal, multicenter, observational study spanning up to 12 years.SettingSix PCD centers in North America.MethodsInclusion criteria were <19 years of age and a confirmed diagnosis of PCD based on electron microscopy and/or genetics. A standardized medical history questionnaire and physical exam were completed during each study visit. Descriptive statistics were performed for the entire cohort as well as for subgroups based on ciliary ultrastructure.ResultsA total of 147 participants were followed for an average of 7.6 ± 3.2 years. Pressure equalization tubes (PETs) were placed in 80%, transient hearing loss was reported in 68%, and persistent hearing loss was reported in 30%. Hearing aids and speech therapy were utilized by 8% and 27%, respectively. PETs were placed earlier in those with inner dynein arm/microtubular disorganization defects than those with outer dynein arm defects. Participants reported chronic nasal congestion in 97%, sinusitis in 87%, and 35% underwent >1 sinus surgery.ConclusionThere is a high prevalence of reported otologic and sinonasal morbidity among people with PCD that begins during early childhood and persists. Further analysis is indicated to evaluate differences over time among participants with varying ultrastructural defects.Level of EvidenceLevel 2.