bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finerenone (Kerendia)
Authors: CADTH  
Published: May 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses finerenone (Kerendia) tablets, 10 mg and 20 mg, oral administration.
Indication: As an adjunct to standard of care therapy in adults with chronic kidney disease and type 2 diabetes to reduce the risk of:

end-stage kidney disease and a sustained decrease in estimated glomerular filtration rate
cardiovascular death, nonfatal myocardial infarction, and hospitalization for heart failure
Lutetium (¹⁷⁷Lu) Vipivotide Tetraxetan (Pluvicto)
Authors: CADTH  
Published: May 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses 177Lu vipivotide tetraxetan (Pluvicto), solution for injection, 1 GBq/mL (27 mCi/mL) at calibration.
Indication: The treatment of adults with prostate-specific membrane antigen-positive metastatic castration-resistant prostate cancer who have received at least 1 androgen receptor pathway inhibitor and taxane-based chemotherapy.
Ciudad, modernidad y tarjeta postal. Una imagen comparada de Santiago de Chile y Temuco a principios del siglo XX
Authors: Azócar-Weisser Javiera , Ardila-Sierra Marcia 
Published: May 2023

Hacia fines del siglo XIX y principios del XX, la élite chilena intenta construir la imagen de un país orgulloso de su desarrollo urbano, elemento central de la modernidad, a través de un medio moderno por excelencia: la fotografía. Las revistas, los álbumes fotográficos y, sobre todo, las tarjetas postales fueron las plataformas para difundir imágenes de las “modernas” urbes de la época. Plazas, parques, avenidas, teatros, edificios públicos y estaciones de trenes, fueron temas recurrentes para representar a las ciudades de un país “civilizado”, “moderno” y “próspero”.
Este artículo aborda la representación urbana construida desde la tarjeta postal a partir de la comparación de dos casos de estudio: Santiago de Chile, capital, y Temuco, ciudad perteneciente a la periferia territorial del periodo. La finalidad es analizar este tipo de imágenes en tanto dispositivos de un discurso que construye cierto imaginario en el marco del proceso de modernización del Estado chileno.
PENGARUH PENAMBAHAN LIMBAH SERAT BAJA TERHADAP KEKUATAN DAN MODULUS ELASTISITAS BETON
Authors: Pitaloka Oky Sandra 
Published: May 2023

Secara struktur beton mempunyai sifat mekanis seperti mempunyai tegangan tekan cukup besar yang merupakan kelebihannya dan mempunyai kuat tarik dan getas yang merupakan kelemahannya. Untuk meningkatkan kemampuan beton bisa dengan menambahkan serat-serat baja. Metode penambahan serat baja masih jarang dilakukan dikarenakan masih kurang ekonomis. Oleh karena itu pada penelitian ini digunakan alternatif serat baja yang lebih murah dan ramah lingkungan yaitu serat kawat yang berasal dari limbah ban bekas. Penelitian ini bertujuan untuk menguji menggunakan campuran beton dengan variasi prosentase dan mengukur seberapa besar pengaruh dari berbagai variasi tersebut terhadap sifat-sifat fisis dan mekanis beton. Dalam Penelitian ini peneliti akan menguji beton normal dan beton serat dengan menggunakan serat kawat ban bekas dengan prosentase 0,5 %, 1,5 %, 2,5 % Dari hasil pengujian kuat tekan pada umur 7, 14 dan 28 hari dengan penambahan serat baja sebesar 0,5%, 1,5%, mengalami kenaikan yang signifikan dibandingan dengan beton normal, pada presentase sebesar 2,5% menghasilkan kuat tekan tertinggi dibandingkan dengan beton lainnya yaitu sebesar 31,48 MPa Sedangkan dari hasil pengujian kuat tarik lentur pada umur 7, 14, 28 hari dengan penambahan serat baja sebesar 0,5%, 1,5%, mengalami kenaikan yang signifikan pada tes kuat tarik lentur dibandingkan dengan beton normal. Pada penambahan serat baja dengan presentase 2,5% pada mengalami menghasilkan kuat tarik lentur tertinggi dibandingkan dengan beton lainnya yaitu sebesar 7,41 MPa.Kata Kunci : Beton serat, Serat Baja, Kuat tekan
Determinan Faktor Risiko Kejadian Hipertensi di Wilayah Kerja UPTD Puskesmas Sukamulya Kabupaten Tangerang Provinsi Banten Tahun 2021
Authors: Apriyanto Iyan , Sulistyowati Yeny , Utami Sri 
Published: May 2023

WHO menyatakan hipertensi telah mengakibatkan kematian sekitar 8 juta orang pertahun. Data Riskesdas 2018, prevalensi hipertensi penduduk umur >18 tahun di Indonesia sebesar 34,1% dan di Provinsi Banten mencapai 30,45%. Tahun 2020 UPTD Puskesmas Sukamulya, hipertensi menempati kasus tertinggi PTM yaitu 5.738 kasus (50,1%). Tujuan penelitian ini adalah membuktikan determinan faktor risiko kejadian hipertensi di wilayah kerja UPTD Puskesmas Sukamulya Kabupaten Tangerang Provinsi Banten Tahun 2021. Metode yang digunakan Penelitian kuantitatif dengan desain case-control. Menggunakan teknik simple random sampling dengan jumlah sampel kasus 113 responden dan kontrol 113 responden. Hasil bivariat menunjukkan ada hubungan yang signifikan antara umur p value = 0,001, jenis kelamin p value = 0,0005, riwayat keluarga p value = 0,0005 obesitas p value = 0,0005, kebiasaan merokok p value = 0,0005, kurang aktifitas fisik p value = 0,0005, konsumsi makanan asin p value = 0,008, dislipidemia p value = 0,0005, konsumsi alkohol p value = 0,029, stres p value = 0,0005 dengan kejadian hipertensi di wilayah kerja UPTD Puskesmas Sukamulya. Hasil multivariat menunjukkan stres merupakan faktor dominan terhadap kejadian hipertensi dengan OR = 210, 323. Stres adalah determinan faktor risiko hipertensi di wilayah kerja UPTD Puskesmas Sukamulya. Mengikuti kegiatan CERDIK (Cek kesehatan secara berkala, Enyahkan asap rokok, Rajin beraktivitas fisik, Diet yang sehat dan seimbang, Istirahat yang cukup dan Kelola stres) merupakan salah satu kegiatan pencegahan faktor risiko hipertensi. Kata kunci: Hipertensi, Faktor risiko, Kegiatan CERDIK
POST ISCHEMIC STROKE IMAGING AND ITS CLINICAL RELEVANCE: A SYSTEMATIC REVIEW
Authors: Amalia Amin Assyifa 
Published: May 2023

Stroke is a focal or global functional brain disorder that starts suddenly and lasts longer than 24 hours and is caused by changes in cerebral blood flow. It is not caused by transient cerebral circulatory abnormalities, brain tumors, or secondary strokes as a result of trauma or infection. Strokes can develop in any part of the brain. Ischemia or brain hemorrhage are also potential causes of a stroke that occurs suddenly and leads in neurologic impairments. Strokes are classified into two types: bleeding and non-bleeding. Both are potentially fatal. Several studies have found that imaging is required before treating an acute ischemic stroke. The importance of imaging after stroke treatment, on the other hand, is less obvious. Bleeding, particularly cerebral haemorrhage, is the most feared complication in people who have had acute ischemic stroke treatment. As a result, the AHA/ASA IV-tPA guidelines recommend that a non-contrast computed tomography (NCCT) brain scan be performed at least 24 hours after therapy. Non-contrast CT (NCCT) is still the cheapest, quickest, most generally available, and simplest method for diagnosing intracerebral bleeding after an ischemic stroke. However, MRI with the right sequences may be able to detect the same thing. The NCCT may frequently detect hyperdense regions following treatment for acute ischemic stroke. Magnetic resonance imaging (MRI) is one of the most commonly used imaging methods both before and after stroke treatment due to the wealth of information it gives. Finally, post-ischemic stroke imaging is becoming increasingly essential because it can provide both specific clinical guidance and a better knowledge of the processes that occur after such a severe impact on the brain. It may aid in the prediction of long-term outcomes and, in the future, may assist clinicians in tailoring and optimizing rehabilitation efforts for specific patients.
ESCHERICHIA COLI ENTEROHEMORRÁGICA E PERFIL DE RESISTÊNCIA A ANTIMICROBIANOS EM SUÍNOS CRIADOS NO ESTADO DO PARÁ
Authors: Monger Suellen Da Gama Barbosa , Rocha Daniela Cristiane Da Cruz , Costa Débora De Castro , De Souza Natália Freitas , Marinho Anderson Nonato Do Rosario , Pereira Washington Luiz Assunção 
Published: May 2023

O objetivo deste estudo foi investigar a ocorrência e o perfil de resistência antimicrobiana de Escherichia coli enterohemorrágica em suínos criados no Estado do Pará. 200 amostras fecais de suínos foram coletadas e semeadas em caldos Escherichia coli e Gram negativo, e posteriormente incubadas em Agar MacConkey. Colônias suspeitas foram identificadas em ágar tríplice açúcar ferro para caracterização bioquímica e analisadas a partir de PCR Multiplex, seguido de investigação de susceptibilidade aos agentes antimicrobianos disponíveis usando o sistema VITEK® 2 Compact (bioMérieux)®. Das 15 propriedades estudadas, foram verificadas E. coli enterohemorrágica (EHEC) em seis, sendo isoladas em 11% (22/200) dos animais pesquisados. O teste de susceptibilidade aos antimicrobianos demonstrou que 50% dos casos apresentaram resistência a pelo menos um antimicrobiano: 31,81% para ácido nalidíxico, 27,27% para trimetoprim-sulfametoxazol, 18,18% para ampicilina e 13,63% para cefalotina. Neste estudo, cepas de Escherichia coli enterohemorrágica foram identificadas em suínos, e foi possível verificar a resistência dessas cepas patogênicas a alguns antimicrobianos utilizados na rotina veterinária e humana, como trimetoprim-sulfametoxazol e ampicilina, que são indicados para combatê-las, surgindo preocupação quanto ao tratamento de doenças que envolvem E. coli patogênica, bem como a seleção de genes de resistência em bactérias presentes na microbiota animal utilizada como alimento, e a possibilidade de transferência desses genes para bactérias do trato intestinal humano.
NUTRITIONAL METHODS TO INDUCE MOLTING IN LAYING HENS IN CAGE-FREE SYSTEM
Authors: Valentim Jean Kaique , Bittencourt Tatiana Marques , D' Ávilla Lima Heder José , Matos e Silva Nayara Emanoelle , Tossué Fernandes Jesuino Mukissaí , Mendes Janaína Palermo , Procópio Diego Pierotti , Moraleco Debora Duarte 
Published: May 2023

The objective of this study was to evaluate the productive performance, the efficiency of forced seedlings, and the quality of eggs of Black Avifran laying hens reared in Cage-Free System using alternative foods as an induced seedling method. The experiment lasted 56 days, divided into two phases. The first stage called the molting phase lasted 14 days, and the next phase was divided into two periods of 21 days post-molting. A total of 144 laying hens were divided into three treatments and six replicates with 8 laying hens each. The experimental treatments were: food restriction (conventional method), total feeding with ground corn and total feeding with dry grains of the distillery with corn soluble (DDGS) for seedling induction. In the seedling phase, the following were evaluated: days to cease posture, food intake, percentage of laying, and weight loss of laying hens. In the post-molting phase, egg quality, egg weight, shell weight, albumen weight, yolk weight, yolk color, yolk percentage, shell and albumen percentage, Haugh Unit, egg production, feed intake, feed conversion by mass and dozen eggs were evaluated. The use of corn and DDGS promoted a significant difference (p<0.05) only for the parameters: food intake, feed intake, and yolk color, which obtained lower values when compared to the conventional method. It is assumed that the consumption time of the ingredients (14 days) was not enough for the laying hens to achieve the expected weight loss of 25%. However, a satisfactory time was obtained to cease the posture. Corn and DDGS can be used as an alternative method to feed restriction for the induced seedling of Black Avifran laying hens reared in the Cage-Free system, as they do not alter the performance and quality of eggs in the post-molting period.
CHELONID ALPHAHERPESVIRUS 5 EM TUMORES CUTÂNEOS DE TARTARUGAS VERDES (CHELONIA MYDAS) ENCALHADAS NO NORDESTE DO BRASIL
Authors: Silva Júnior Edson Soares da , Rossi Silmara , Zamana Roberta Ramblas , Gattamorta Marco Aurélio , Freire Augusto Carlos da Boaviagem , Revorêdo Rafael Ângelo , Farias Daniel Solon Dias de , Sacristán Carlos , Bomfim Aline Da Costa , Matushima Eliana Reiko , Silva Flávio José de Lima , Gavilan Simone Almeida 
Published: May 2023

As tartarugas-verdes (Chelonia mydas) são afetadas pela fibropapilomatose (FP), doença que pode ser uma ameaça para elas. O trabalho teve como objetivo descrever as características histopatológicas dos tumores sugestivos de FP e pesquisar a presença de DNA de Chelonid alphaherpesvirus 5 (ChHV5) em lesões cutâneas de 26 tartarugas verdes encalhadas na Bacia Potiguar (nordeste do Brasil). As tartarugas verdes foram encontradas durante o monitoramento diário, e os tumores de FP foram coletados por biópsia ou durante necropsia, quantificados e analisados de acordo com distribuição anatômica, tamanho e Escore de Fibropapilomatose do Atlântico Sudoeste (FPSSWA). Vinte e seis cortes histológicos foram examinados, e 26 amostras fixadas em formalina e embebidas em parafina foram analisadas por reação em cadeia da polimerase (PCR) para detectar o DNA do ChHV5. Um total de 292 tumores foi analisado (1-42 por indivíduo), sendo a maioria com tamanho de 1-4 cm (74%; 218/292 tumores) e presentes nos membros anteriores (48,6%; 142/292 tumores). De acordo com o FPSSWA, a maioria das tartarugas verdes estava afetada de forma leve (53,8%; 14/26). O exame histopatológico revelou características previamente descritas na literatura (projeções papilares da camada epitelial, hiperceratose, hiperplasia da camada basal, fibroblastos em proliferação bem diferenciados) classificando os tumores como papilomas ou fibropapilomas. Com relação aos resultados de PCR, 79,9% das amostras de tumor testadas foram positivas para ChHV5 e as sequências foram obtidas em todas as amostras amplificadas. Nossas sequências UL30 são idênticas a várias sequências descritas em tartarugas marinhas do Brasil, enquanto as sequências UL18 e UL27 são mais semelhantes as de tartarugas verdes na Flórida. Nosso estudo relata detecção e caracterização molecular do ChHV5 em tartarugas verdes encalhadas na Bacia Potiguar, importante área de alimentação com alta frequência de ocorrência de FP.
Response of rosemary plant to the effect of Nano-NPK fertilizer and biological factors and their effect on the active substances
Authors: Hamid H.  Mahewish  , Falah H.  Radi  , Mohammed N . Radhi  
Published: May 2023

The study was carried out in the canopy-covered by Alsaran of the Faculty of Agriculture and marshes University of Thi- Qar on 01.11.2020. The experiment was terminated on 15.06.2021 On the rosemary plant that old of age was one year at three seedlings per unit experimental, thus became the number of seedlings 81 Seedlings in plastic anvils, container on sandy loam soil and peat moss with a percentage 3 :1 The experiment included the treatment of the balanced compound Nano-NPK fertilizer by spray on leaves of the plant at concentrations ( 0, 25, 75) mg. l-1 by three times for a period 15th day between one adding and another, and the biological factor was added at concentrations (0, 10, 20) ml by one adding. And carried out an experiment factorial according to Randomized Complete Block Design RCBD With three replications for each treatment, the results were compared according to the least significant difference test at the probability level of 5%. The statistical analysis results showed superiority in the compound Nano-fertilizer by height and number of branches, amount of oil and its density, and some of the active substances Cymen And the Camphene And Rose Mari acid reached (53.44 cm, 78.66 branches, 2.2989 g 00. gm-1, 1.0348, 4.671, 135.70) respectively compared to the lowest value for the comparison treatment. The biological factor was superior in the following characteristics (height, branches number, oil quantity, oil density, and active compounds). Cymen and the Camphene and Rose Mari acid reached (49.77 cm, 67.44) and 2.3277 g.100. g-1), respectively, compared with the lowest value for comparative treatment. As for the interaction, the treatment outperformed N2B2 In the adjective of the number of branches insignificant, and the treatment of N2B1 In the amount of oil, oil density and some active compounds, Rose Mari acid. It had a significant effect on the treatment N0B1 Significant effect on the active compound Camphene.
Effect of foliar spraying with atonic on some vegetative and flowering characteristics of cucumber Cucumis melo. Var flexuosus
Authors: Ghufran Zaid Khalaf AL-Rikabi  , Batool Hanoon Falih AL-Zubaidy  
Published: May 2023

The experiment was carried out in one of the unheated greenhouses in the station of the College of Agriculture and Marshes / University of Dhi Qar during the fall season 2020-2021, to study the effect of the atonic biostimulant on the growth and yield of cucumber (Cucumber).Cucumis melo. Var flexuosus naud) Under protected cultivation, and used two types of cucumber plant (al - Baghdadi and Hillawi), and implemented using the design of full random sectors included working experience and three replicates a compatibility between the two types of Alqthae option and four concentrations of the catalyst vital Alatunak were compared to the average transaction under test less significant difference Significant Differences Least LSD at a probability level of 0.05.
Study of clinical signs and post mortem changes in vaccinated and unvaccinated buffaloes experimentally infected with the virulent Pasturella multocida bacterium that causes hemorrhagic septicemia in buffaloes-South of Iraq .
Authors: Jalil Abed Gatie  , Ibrahim Abbas Mohammed  
Published: May 2023

Hemorrhagic septicemia is an important disease of cattle and buffaloes. Which causes disease revolutions with great economic losses in Asia and Africa, and in Iraq it is considered one of the more dangerous diseases in buffaloes than in cows. This study was prepared to reassess the vaccination program against hemorrhagic septicemia, which is used in Iraq, especially in buffaloes, due to the nature of their lives in the marshes and as a result of the epidemic that occurred in 2008 by conducting a challenge test on buffaloes directly with a study of some physiological and immunological aspects before and after examining the challenge, as well as the effect of virulent germ The animal body has clinical symptoms and pathological changes when the post mortem is performed. This study has the advantage of using the buffalo itself by performing the challenge assay directly on it. We can depend on animal mortality, clinical symptoms and local interaction to distinguish animal resistance to the challenge test and the efficacy of the vaccine type in immunization of buffaloes against hemorrhagic septicemia. Clinical and pathological symptoms may be used on the field diagnosis of the disease and are considered as enhancement for bacterial diagnosis.
ESTIMATING THE AMOUNT OF THE WASTED WATER DUE TO FAULTY ACTIVITIES IN SOME AREAS IN DHI QAR/ SOUTHERN IRAQ
Authors: Hussein Khalefa Chlaib  , Jalal Hameed Ali  , Najm Abed Yasir  , Alaa Ibrahim Badi  , Jaber Hameed Muttair  
Published: May 2023

Because of the poor water situation in Iraq in general and the southern governorates in particular requires prior consideration to find appropriate solutions. In this study، the researchers sought to estimate the amount of waste water in irrational and irrational ways in five vital areas within Thi-Qargovernorate, which are Qalat Suker, Al-Rifai, Al-Shatrah, Sug Al-Shuyukh and Al-Fuhud cities using the questionnaire distributed to citizens. The total amount of water wasted per month in these five areas due to the unemployed faucets is 1752660 liters. Because of the leakage of the water reservoirs without a roving، it is 901906480 liters، because washing the cars with the water hose is 952632 liters and keeping the faucets open during the cleaning of the teeth is 288845180 liters. Khartoum is 23163505 liters. The researchers concluded that very large quantities of drinking water are wasted daily due to erroneous activities by the population in the study areas where 1216620475 (one billion two hundred and sixteen million six hundred and twenty five hundred) liters per month are lost. Given that the average person in developing countries may need about 80 liters per day for all his needs، these amounts would have been wasted if it was used to provide 510000 citizens a day with drinking water
Influence of variety, organic and mineral fertilization on the qualitative and quantitative characteristics of cucumbers crop (Cucumis sativus L.)
Authors: Athari J. Mohammed  , Muaid S. Ali  , Razzaq A. Saqar  
Published: May 2023

The experiment was carried out at the Agricultural Research Station of the College of Agriculture and the Marshlands / University of Thi-Qar, located in Al- Mustufawia for the agricultural season (2019-2020). The study was the effect of cultivar and organic and mineral fertilization on the qualitative and quantitative characteristics of cucumber crops grown in greenhouses, and applied according to the factorial experiments inside the split plots, using the complete randomized sectors with three replications. The factors of research were: two cultivars (Datis and Sakata) occupied the main plots, three levels of organic fertilization occupied the secondary plots which included control treatment O1, cow manure O2(2.457 tons of greenhouse-1) and poultry manure O3(3.713 tons of greenhouse-1) and the third factor was four levels of mineral fertilization (NPK) including control treatment M1, M2 (2.250 kg. dunam-1), M3 (3.350 kg. dunam-1), and M4 (4.450 kg. dunam-1) which occupied the sub-plots. The results showed that Datis cultivar significantly outperformed Sakata cultivar in yield per plant, total yield, leaf content of nitrogen and phosphorus, and fruit content of carbohydrates, reaching (1.402 kg. plant-1, 24.24 tons .greenhoues-1, 2.2517%, 0.4069%, 1.2876%) respectively. On the other hand, the treatment of organic fertilizer O3 recorded a significant effect in the following crop traits such as leaf area, total yield, leaf content of nitrogen and phosphorus, and fruit content of carbohydrate, reaching (178.0 cm2, 24.36 tons. greenhouse-1, 2.5017%, 0.4608%, 1.3561%). Respectively compared to other treatments, total yield, leaf content of nitrogen and phosphorus, reaching (180.1 cm2, 25.88 t. greenhoues-1, and 2.3478%, and 0.4561%) to other treatments. The treatment M2 significantly outperformed in yield per plant (1.682) kg. plant-1 and treatment M3 significantly exceeded the fruit's carbohydrate content, reaching (1.2930%). All the combinations among this study's treatments were compared to meet their significant effecting on all traits.