bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emvolio - A battery operated portable refrigerator preserves biochemical and haematological integrity of biological samples in preclinical studies
Authors: Maity Swastika , Aakriti Jaya , Manandhar Suman , Anchan Sharad B , Bhat Ashlesh , Shetty Mayur U , Nayak Yogendra 
Published: January 2023

Background: Emvolio is a non-medical device, indigenously developed portable refrigeration for maintaining the internal temperature 2–8˚C. The Indian Patent Office has granted patent for applications such as preservation and transport of medicines, vaccines, food, beverages, dairy etc. Further, use of Emvolio can be utilized in transport and store biologicals to preserve their biochemical and cellular integrity. The objective of this study was to evaluate the biochemical and haematological integrity of biological samples such as rat blood, serum and liver. Methods: The steady temperature was maintained inside the Emvolio, and it was compared to that of thermocol and polypropylene boxes aided with frozen gel packs. The blood and liver samples were isolated from Wistar rats and kept in Emvolio, thermocol and polypropylene boxes for 10 hrs, and the temperature was monitored. The blood parameters, namely red blood cells (RBC), white blood cells (WBC), platelets, haematocrit, haemoglobin, mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC) and red cell distribution width (RDW), serum parameters like alanine transaminase, alkaline phosphatase, total protein, albumin, creatine kinase, blood urea nitrogen and liver parameters like superoxide dismutase (SOD), glutathione (GSH), catalase were estimated and compared. Results: Emvolio maintained a constant inner temperature range of 2–8˚C, whereas a significant temperature variation was seen in thermocol and polypropylene boxes. There was no significant deviation in the parameters tested when samples were kept in Emvolio for six hours compared to the zero hour readings. In contrast, there was a significant deviation among the parameters for the samples kept in thermocol and polypropylene boxes for six hours compared to zero hour parameters. Conclusions: Emvolio maintained constant temperature and preserved the biological integrity of rat blood, serum and liver. Thus, Emvolio can be efficiently used as a biological sample carrier, especially in preclinical studies.
Dynamic pressure surface deformation measurement based on a chromatic confocal sensor
Authors: Zhao Bin , Li Junyi , Mao Xiaoxiao , Sun Fei , Gao Xiumin 
Published: January 2023

To enable the real-time measurement of pressure deformations in sealed cavities, a high-precision method of detecting the deformation of a material surface is proposed. By combining a chromatic confocal displacement sensor with a pressure sensor, we can acquire dynamic online strain measurements that consider the effects of the deformed material and internal environmental conditions. A

90

m
m

×

90

m
m

static mechanical cylindrical cavity is simulated using finite element software. The interior of the cylindrical cavity is continuously pressurized at up to 400 kPa with a material deformation of 300 µm. We experimentally obtain the spectral peak wavelengths corresponding to the surface deformation experiment, record the spectral data at 20 kPa intervals, and use the Voigt fitting algorithm to reduce sensor errors. The results show that the experimental results differ from the simulated results by 1.43 µm, with a relative error of 0.083% after sequential pressurization and depressurization using a pressure calibrator, and the uncertainty error of pressure deformation measurement is 1.495 µm. Thus, the proposed method is robust against external disturbances and is suitable for micrometer-level surface deformation monitoring, which has numerous applications in the high-precision inspection industry.
Proposal for the detection of breast cancer at its early stage using wave-theory-based analysis in a tapered fiber structure illuminated by the Bessel–Gauss beam for enhanced sensitivity
Authors: Saha Bijaya , Goswami Nabamita , Saha Ardhendu 
Published: January 2023

An analytical exploration of a fiber-optic biosensor with a tapered structure for the detection of breast cancer at its early stage by illuminating the Bessel–Gauss beam in a multilayer structure, using wave-theory-based technique, is proposed to acquire closer results between experimental and theoretical models. By using a Gaussian beam, the observed sensitivity is 2688.5 dB/RIU and 0.204 nm/ng/mL, where all the results are in good agreement with the experimental outcomes reported by Sun et al. [Opt. Commun. 463, 125375 (2020)10.1016/j.optcom.2020.125375]. Thus, this proposed theory is experimentally validated. Now, this tapered theoretical analysis is further extended utilizing the Bessel–Gauss beam, where for the first time, to the best of our knowledge, the discerned sensitivity is enhanced to 14,979.8 dB/RIU and 0.33 nm/ng/mL with a resolution of

6.

68

×

1

0

−
7

, which is 6.59 times superior to the reported results to date. Higher spectral shifts are noticed using the wavelength interrogation technique for the concentration of (2–15) ng/mL of HER2 biological marker. Thus improvement in sensitivity and resolution at lower concentrations is achieved, which indicates the proposed idea for the identification of breast cancer at its early stage.
Investigation of free space optical communications with binary ghost imaging
Authors: Huang Xianwei , Tan Wei , Jiang Teng , Nan Suqin , Bai Yanfeng , Fu Xiquan 
Published: January 2023

This paper proposes a free space optical (FSO) communications system based on ghost imaging, and the signal transmission through a 1 km horizontal turbulent channel is numerically investigated. The information is modulated and encoded into a sequence of binary numbers by ghost imaging with object light quantization, and these binary signals are transmitted to a receiver with vortex beams. The communications performance depends on the repeating times of the ghost imaging, and the bit error rate is zero as the repeating times increase to 3000. The security of the communications system is analyzed, and it is found that the information cannot be correctly decoded without a transformation matrix and secret key. It is confirmed that larger repeating times in the ghost imaging can contribute to the security enhancement and better communications performance. Our results provide a secure scheme for a FSO communications system in the presence of atmospheric turbulence, which has potential for applications in future communications.
Knowledge sharing behaviour among head nurses in online health communities: The moderating role of knowledge self-efficacy
Authors: Shehab Salah , Al-Bsheish Mohammad , Meri Ahmed , Dauwed Mohammed , Aldhmadi Badr K. , Kareem Haitham Mohsin , Alsyouf Adi , Al-Mugheed Khalid , Jarrar Mu’taman 
Published: January 2023

Background
Head nurses are vital in understanding and encouraging knowledge sharing among their followers. However, few empirical studies have highlighted their contribution to knowledge-sharing behaviour in Online Health Communities (OHCs). In addition, scant literature has examined the moderating role of knowledge self-efficacy in this regard.

Purposes
This study examines the moderating role of self-efficacy between the association of four selected individual factors of head nurses (i.e., Trust, Reciprocity, Reputation, and Ability to Share) and their knowledge-sharing behaviour in OHCs in Jordan.

Method
The data were obtained by using a self-reported survey from 283 head nurses in 22 private hospitals in Jordan. A moderation regression analysis using a structural equation modelling approach (i.e. Smart PLS-SEM, Version 3) was utilised to evaluate the study’s measurement and structural model.

Results
Knowledge self-efficacy moderates the relationship between the three individual factors (i.e., Trust, Reciprocity, and Reputation) and knowledge-sharing behaviours. However, self-efficacy did not moderate the relationship between the ability to share and knowledge-sharing behaviours.

Implications
This study contributes to understanding the moderating role of knowledge self-efficacy among head nurses in online healthcare communities. Moreover, this study provides guidelines for head nurses to become active members in knowledge sharing in OHCs. The findings of this study offer a basis for further research on knowledge sharing in the healthcare sector.
Supporting lifestyle change in obese pregnant mothers through the wearable internet-of-things (SLIM) -intervention for overweight pregnant women: Study protocol for a quasi-experimental trial
Authors: Saarikko Johanna , Axelin Anna , Huvinen Emilia , Rahmani Amir M. , Azimi Iman , Pasanen Miko , Niela-Vilén Hannakaisa 
Published: January 2023

Objectives
To assess, in terms of self-efficacy in weight management, the effectiveness of the SLIM lifestyle intervention among overweight or obese women during pregnancy and after delivery, and further to exploit machine learning and event mining approaches to build personalized models. Additionally, the aim is to evaluate the implementation of the SLIM intervention.

Methods
This prospective trial, which is a non-randomized, quasi-experimental, pre-post intervention, includes an embedded mixed-method process evaluation. The SLIM Intervention is delivered by public health nurses (n = 9) working in maternity clinics. The public health nurses recruited overweight women (n = 54) at their first antenatal visit using convenience sampling. The core components of the intervention i.e. health technology, motivational interviewing, feedback, and goal setting, are utilized in antenatal visits in maternity clinics starting from gestational week 15 or less and continuing to 12 weeks after delivery. Mixed effect models are used to evaluate change over time in self-efficacy, weight management and weight change. Simple mediation models are used to assess calories consumed and moderate to vigorous physical activity (MVPA) as mediators between self-efficacy and weight change. Signal processing and machine learning techniques are exploited to extract events from the data collected via the Oura ring and smartphone-based questionnaires.

Discussion
The SLIM intervention was developed in collaboration with overweight women and public health nurses working in maternity clinics. This study evaluates the effectiveness of the intervention among overweight women in increasing self-efficacy and achieving a healthy weight; thus, impacting the healthy lifestyle and long-term health of the whole family. The long-term objective is to contribute to women’s health by supporting weight-management through behavior change via interventions conducted in maternity clinics.

Trial registration
The trial was registered at the Clinicaltrials.gov register platform (ID NCT04826861) on 17 March 2021.
Identification and characterization of probiotics isolated from indigenous chicken (Gallus domesticus) of Nepal
Authors: Gupta Mohan , Raut Roji , Manandhar Sulochana , Chaudhary Ashok , Shrestha Ujwal , Dangol Saubhagya , G. C. Sudarshan , Budha Keshab Raj , Karki Gaurab , Díaz-Sánchez Sandra , Gortazar Christian , de la Fuente José , Rajbhandari Pragun , Manandhar Prajwol , Napit Rajindra , Karmacharya Dibesh 
Published: January 2023

Background
Excessive and irrational use of antibiotics as growth promoters in poultry has been one of key factors contributing to increased emergence of antibiotics resistant bacteria. Several alternatives for antibiotic growth promoters are being sought, and the search for effective probiotics to be used as feed additives is amongst the promising ones. Our study aimed to isolate and test potential probiotics bacteria from cloacal swabs of various indigenous chicken (Gallus domesticus) breeds from rural outskirts of the Kathmandu valley (Nepal).

Methods
Selective isolation of probiotics was conducted by micro-aerophilic enrichment of sample in MRS Broth at 37°C, followed by culturing on MRS agar supplemented with 5 g/L of CaCO3. Isolated bacterial colonies producing transparent halo were selected as potential lactic acid bacteria (LAB), and tested for their antibacterial activity, phenotypic and biochemical characteristics, acidic yield, and tolerance to acid and bile.

Results
A total of 90 potential LAB were isolated from cloacal samples collected from 41 free-ranging chickens of indigenous breeds. Of these, 52 LAB isolates (57%) showed variable antibacterial activity to at least one bacterial pathogen. Of 52 LAB, 46 isolates fulfilled phenotypic and biochemical criteria of Lactobacillus spp. Of these, 37 isolates produced varying percentage yields of lactic acid, 27 isolates showed survival at pH 3.0, and 17 isolates showed survival tolerances in the presence of 0.3% and 0.5% bile salts for 24 hours. Phylogenetic analysis of 16S rDNA sequencing of LAB isolates fulfilling in vitro probiotics properties showed that 3 isolates had genetic identity of 99.38% with Lactobacillus plantarum, while one isolate was genetically similar (99.85%) with the clade of L. reuteri, L. antri and L. panis.

Conclusion
Our study identified four Lactobacillus spp. strains having potential probiotics properties. Further investigations are needed to evaluate these isolates to be used as poultry probiotics feed supplement.
Post-intervention acceptability of multicomponent intervention for management of hypertension in rural Bangladesh, Pakistan, and Sri Lanka- a qualitative study
Authors: Jafar Tazeen H. , Tavajoh Saeideh , de Silva H. Asita , Naheed Aliya , Jehan Imtiaz , Kanatiwela de Silva Chamini , Chakma Nantu , Huda Maryam , Legido-Quigley Helena ,   on behalf of COBRA-BPS Study Group
Published: January 2023

Background
COBRA-BPS (Control of Blood Pressure and Risk Attenuation-Bangladesh, Pakistan, Sri Lanka), a multicomponent, community health-worker (CHW)-led hypertension management program, has been shown to be effective in rural communities in South Asia. This paper presents the acceptability of COBRA-BPS multicomponent intervention among the key stakeholders.

Methods
We conducted post-implementation interviews of 87 stakeholder including 23 community health workers (CHWs), 19 physicians and 45 patients in 15 rural communities randomized to COBRA-BPS multicomponent intervention in in Bangladesh, Pakistan, and Sri Lanka. We used Theoretical Framework for Acceptability framework (TFA) with a focus on affective attitude, burden, ethicality, intervention coherence, opportunity cost, perceived effectiveness and self-efficacy.

Results
COBRA-BPS multicomponent intervention was acceptable to most stakeholders. Despite some concerns about workload, most CHWs were enthusiastic and felt empowered. Physicians appreciated the training sessions and felt trusted by their patients. Patients were grateful to receive the intervention and valued it. However, patients in Pakistan and Bangladesh expressed the need for supplies of free medicines from the primary health facilities, while those in Sri Lanka were concerned about supplies’ irregularities. All stakeholders favoured scaling-up COBRA-BPS at a national level.

Conclusions
COBRA-BPS multicomponent intervention is acceptable to the key stakeholders in Bangladesh, Pakistan and Sri Lanka. Community engagement for national scale-up of COBRA-BPS is likely to be successful in all three countries.
Secular trends in body image dissatisfaction and associated factors among adolescents (2007–2017/2018)
Authors: Gonzaga Isadora , Ribovski Marina , Claumann Gaia Salvador , Folle Alexandra , Beltrame Thais Silva , Laus Maria Fernanda , Pelegrini Andreia 
Published: January 2023

Objective
To assess secular trends in body image dissatisfaction and associated factors among adolescents over a 10-year period (2007-2017/2018).

Methods
The sample included 1,479 (2007, n = 531; 2017/2018, n = 948) high school adolescents of both sexes, aged 14 to 18 years, of schools in a city in southern Brazil, in 2007 and 2017/2018. Data were collected on sex, age, physical activity (IPAQ, short form), anthropometric measurements (body weight, height, and triceps and subscapular skinfolds), and body image dissatisfaction (figure rating scale). The variables were compared with Independent samples t-test and Mann–Whitney U-test. The associations between sex and other variables were examined with chi-square test, and the factors associated with body image were identified with multinomial logistic regression.

Results
Most adolescents were dissatisfied with their body image in 2007 (65,2%) and 2017/2018 (71,1%). The prevalence of body dissatisfaction increased by 9.2% over the 10-year period, particularly dissatisfaction with thinness (21.3%). After stratification by sex, in 2017/2018 sample, dissatisfaction with overweight was 46.1% greater in boys, and dissatisfaction with thinness was 66.9% greater in girls. Factors found to be significantly associated with body image dissatisfaction were physical activity level, and body adiposity.

Conclusions
There was a secular trend toward increased body image dissatisfaction in both sexes. Future efforts should go beyond scientific production, in public and private environments aimed at increasing awareness of health issues related to body care in the physical, psychological, and environmental domains.
Perspectives on dental health and oral hygiene practice from US adolescents and young adults during the COVID-19 pandemic
Authors: Zhang Long , Waselewski Marika , Nawrocki Jack , Williams Ian , Fontana Margherita , Chang Tammy 
Published: January 2023

Background
Adolescence is a critical time for adopting health behaviors which continue through adulthood. There is a lack of data regarding perspectives of US adolescents and young adults on their dental health and oral hygiene practice.

Methods
Adolescents and young adults, age 14–24, from MyVoice, a nationwide text message poll of youth. were asked five open-ended questions on the importance of dental health and impact of the COVID-19 pandemic. Responses were qualitatively analyzed using thematic analysis. Chi-square test was used to examine differences in experiences by demographics.

Results
Of 1,148 participants, 932 responded to at least one question. The mean age was 19 years. Respondents were largely male (49.5%) and non-Hispanic white (62.4%). Most (92%) respondents perceived dental health as important or somewhat important and emphasized overall dental health and hygiene (38.6%) and aesthetics (18.3%). About half (49.2%) of respondents stated they have had at least one cavity since middle school. Just over half (54.8%) reported brushing and flossing to care for their dentition. 58% visited a dentist at least every 6 months, while 38% visited a dentist less frequently or not at all. Being non-cisgender, non-Hispanic black, Hispanic, and receipt of free or reduced lunch was associated with less frequent dental visits. 44% stated COVID-19 impacted their dental health, with many mentioning scheduling difficulties or worsened dental hygiene.

Conclusions
Most youth in our study consider dental health important, though their oral hygiene practice may not follow ADA guidelines and self-reported dental caries are high. Dental healthcare among youth has been affected by the COVID-19 pandemic with interruption in regular dental visits and changes in hygiene habits. Re-engagement of adolescents and young adults by dental care providers via greater access to appointments and youth-centered messaging reinforcing hygiene recommendations may help youth improve dental health now and in the future.
Impact of a Novel Digital Therapeutics System on Nonalcoholic Steatohepatitis: The NASH App Clinical Trial
Authors: Sato Masaya , Akamatsu Masatoshi , Shima Toshihide , Ikegami Tadashi , Yanase Mikio , Mikami Shintaro , Imamura Jun , Nakatsuka Takuma , Tateishi Ryosuke , Yamauchi Naoko , Ushiku Tetsuo , Okanoue Takeshi , Fujishiro Mitsuhiro , Hida Eisuke , Koike Kazuhiko 
Published: January 2023

INTRODUCTION:
Management of nonalcoholic steatohepatitis (NASH) is a currently unmet clinical need. Digital therapeutics (DTx) is an emerging class of medicine that delivers evidence-based therapeutic interventions. This study was aimed at investigating the efficacy of DTx in patients with NASH.

METHODS:
We conducted a multicenter, single-arm, 48-week trial in 19 patients with biopsy-confirmed NASH. All patients received a DTx intervention with a newly developed smartphone application. The primary endpoint was change in the nonalcoholic fatty liver disease activity score (NAS) without worsening of liver fibrosis. The secondary endpoints included improvement of the NAS by ≥2 points without worsening of liver fibrosis, change in the body weight, and regression of fibrosis.

RESULTS:
After the 48-week DTx intervention, improvement of the NAS was observed in 68.4% (13/19) of patients. The mean change in the NAS from baseline to the end of the intervention was −2.05 ± 1.96 (P < 0.001 when compared with the threshold of −0.7). A decrease in the NAS by ≥ 2 points was achieved in 11 (57.9%). The average weight loss at the end of the intervention was 8.3% (P < 0.001). Reduction of the fibrosis stage was observed in 58.3% when the analysis was limited to patients with stage F2/3 fibrosis. There were no serious adverse events that could be considered as being related to the DTx intervention.

DISCUSSION:
DTx for NASH was found to be highly efficacious and well-tolerated. Further evaluation of the DTx intervention for NASH in a phase 3 trial is warranted.
On-demand continuous-variable quantum entanglement source for integrated circuits
Authors: Günay Mehmet , Das Priyam , Yüce Emre , Polat Emre Ozan , Bek Alpan , Tasgin Mehmet Emre 
Published: January 2023

Abstract
Integration of devices generating non-classical states (such as entanglement) into photonic circuits is one of the major goals in achieving integrated quantum circuits (IQCs). This is demonstrated successfully in recent decades. Controlling the non-classicality generation in these micron-scale devices is also crucial for the robust operation of the IQCs. Here, we propose a micron-scale quantum entanglement device whose nonlinearity (so the generated non-classicality) can be tuned by several orders of magnitude via an applied voltage without altering the linear response. Quantum emitters (QEs), whose level-spacing can be tuned by voltage, are embedded into the hotspot of a metal nanostructure (MNS). QE-MNS coupling introduces a Fano resonance in the “nonlinear response”. Nonlinearity, already enhanced extremely due to localization, can be controlled by the QEs’ level-spacing. Nonlinearity can either be suppressed or be further enhanced by several orders. Fano resonance takes place in a relatively narrow frequency window so that ∼meV voltage-tunability for QEs becomes sufficient for a continuous turning on/off of the non-classicality. This provides as much as 5 orders of magnitude modulation depths.
The crystal structure of (2R,6′R)-2′,7-dichloro-4,6-dimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione, C16H14Cl2O5
Authors: Zhang Meng , Bai Yu-Bin 
Published: January 2023

Abstract
C16H14Cl2O5, orthorhombic, P212121 (no. 19), a = 23.2297(5) Å, b = 16.3509(3) Å, c = 8.7300(2) Å, V = 3315.89(12) Å3, Z = 8, Rgt
(F) = 0.0472, wRref
(F
2) = 0.1268, T = 293 K.