bluuebunny/crossref_metadata_2025_split huggingface dataset:
PP2 alleviates the progression of osteoarthritis by inhibiting Wnt/β-catenin and activating TGF- β/Smad signaling
Authors: Zhang Hao , Li Kai , Chen Wei , Li Xiaoqiang , Wang Jinshu , Wang Taikun , Zhao Qi , Huang Hao , Li Yiting , Tang Yujin , Pan Shengcai , Liu Jia , Wang Liqiang 
Published: February 2023

Abstract

Objective
Explore the effect and mechanism of Src inhibitor PP2 on knee osteoarthritis.
Methods
The protein expressions of Src, p-Src (y418) and p-FAK in normal and OA human chondrocytes were detected by immunofluorescence (IF). Chondrocytes from the femur and tibial plateau of 3-day-old mice were extracted and inoculated into 6-well plates. The chondrocytes were co-cultured with IL-1β and different doses of PP2, and then the degeneration of chondrocytes was observed. The OA model was induced by destabilizing medial meniscectomy in the right knee of mice; two weeks after the operation, different doses of PP2 were injected intraperitoneally. The medicine was given 3 times a week for 6 weeks, and then we took the knee cartilage of each group, and the degree of degeneration was observed.
Results
The levels of Src, p-Src (y418) and p-FAK in knee cartilage tissue of patients with OA were abnormally increased. After chondrocytes were co-treated with IL-1β and different doses of PP2, the results showed that PP2 could reduce the abnormal increase of β-catenin, p-β-catenin and other proteins created by IL-1β and reverse the decrease of p-Smad3, Aggrecan and collagen Ⅱ proteins. Meanwhile, intraperitoneal injection of PP2 in vivo significantly reduced the degeneration of articular cartilage.
Conclusion
Our data show that PP2 can inhibit Wnt/β-catenin and activate TGF-β/Smad signaling, thus protecting the cartilage of OA mice.
The Impact of Meteorological Parameters on the Number of Applications to the Emergency Department with Urticaria: A Retrospective Study
Authors: Delice Orhan , Güçlü Sibel Utlu , Arslan Şenol , Doru Halil İbrahim , Daş Murat 
Published: February 2023

Abstract
Objective
The study aimed to investigate the relationship between the patients who applied to the emergency department with acute urticarial and meteorological factors and determine the associated weather conditions.
Methods
The relationship between acute urticaria patients who applied to the emergency department of a training and research hospital in a city with high altitude and continental climate characteristics in the eastern part of Turkey between January 2019 and December 2019, with meteorological data was evaluated retrospectively. The necessary data for the weather were obtained from the data of the Erzurum Meteorology Directorate, and the patient data were obtained from the hospital information management system and patient files. The meteorological data of the patients at the date of admission and the characteristics of the patients at that date were compared.
Results
The study identified 691 patients who applied to the emergency department diagnosed with urticaria in 2019. According to the seasons, it was observed that the patients applied most frequently in the summer months [(n = 239 (34.6%)]. In the univariable regression model, which was created by taking the values of weather events as a reference on the days when the urticaria presentation was not observed (Group I), it was determined that every 1-hour increase in the sunshine hour increased the probability of urticaria by 7.4% (p = 0.018). When the meteorological parameters on the days without urticaria (Group I) and the days with urticaria presentation (Group II) were compared, the sunshine hours were 7.9 (4.0-10.6) hours in Group II and 6.65 (3.3–8.85) hours in Group I (p = 0.001). Regarding relative humidity, higher humidity rates were observed in Group I compared to Group II (p = 0.009). In terms of mean temperature, daily maximum, and minimum temperature, higher temperature rates were detected in Group II (p < 0.001).
Conclusion
A relationship was determined between urticaria attacks and relative humidity and daily maximum and minimum temperature in patients who applied to the emergency department with acute urticaria.
Ferric Carboxymaltose-mediated Methemoglobinemia
Authors: Özbilen Muhammet , Savrun Şeyda Tuba , Aygün Ali , Kaya Yasemin 
Published: February 2023

Background:
Methemoglobinemia is a life-threatening disorder, with levels above 1
percent considered abnormal and typically resulting from drug or toxic substance exposure.

Case Presentation:
In this study, we describe a case of a 43-year-old woman with a long-standing
complaint of fatigue. Iron deficiency anemia was diagnosed based on the blood test findings of
hemoglobin of 101 g/L, mean red blood cell volume of 75 fL, ferritin of 2.81 ug/L, transferrin saturation
of 4.3 percent, and C-reactive protein of 0.6 mg/L. As a preferred treatment option, 1000 mg
ferric carboxymaltose on two distinct days was preferred. After administering the first dose of the
medication, we noticed incidentally that methemoglobin levels increased to 2.3%. When venous
blood gas was repeated before and after administration of the second dose of the drug, methemoglobin
levels were found to be 0.8% and 1.8%, respectively. There was no change in vital signs in
both two dosages, and she only suffered a temporary sore throat. Her anemia improved with intravenous
iron therapy, and she is currently being followed in our clinic.

Discussion:
No case or research reporting an increase in methemoglobin levels following oral
and/or intravenous treatment to patients with iron deficiency anemia has been found in the literature.
Therefore, this is the first contribution to the existing literature.
Information and Measurement System for Monitoring Beams in Building Structures
Authors: Loktionov A. P. 
Published: February 2023

Purpose of research. The development of a method and algorithm for reducing measurements of beam identification parameters in an information and measurement system for monitoring building structures with measurement of deflections and recovery of actual values of beam initial parameters and external load when solving the inverse Cauchy problem.Methods. The solution of the problem is carried out through formulating the transverse bending of the beam according to the Euler – Bernoulli theory using the method of regularization and reduction of measurements by solving the inverse Cauchy problem by means of linear Lagrangian approximation in the procedure of numerical differentiation of the beam deflection function. A methodology is formulated for identifying insignificant beam identification parameters by comparing the deflection of the beam caused by the parameter under study with the sensitivity threshold of measuring instruments. In this case, the modification of the state space of identification parameters with a decrease in its dimension is simulated.Results. The working capability of the formulated experimental calculation method is confirmed by numerical experiment with a load on the beam in the form of a bending moment, concentrated and (or) constant distributed load. It has been established that when identifying insignificant initial parameters and loads acting on the beam, the reduction of measurements increases the accuracy of restoring the beam identification parameters.Conclusion. The developed methodology can be used to improve the accuracy of inspection methods of construction facilities at the stage of experimental and theoretical research.
Increased Performance of Transformers Language Models in Information Question and Response Systems
Authors: Galeev D. T. , Panishchev V. S. , Titov D. V. 
Published: February 2023

Purpose of research. The purpose of this work is to increase the performance of question and response information systems in Russian. Scientific novelty of the work is to increase the performance for RuBERT model, which was trained to find the answer to the question in the text. As far as a more efficient language model allows more requests to be processed in the same time, the results of this work can be used in various information question and response systems for which response speed is important.Methods. The present work uses methods of processing natural language, machine learning, reducing the size of artificial neural networks. The language model was configured and trained using Torch and Onnxruntime machine learning libraries. The original model and training dataset were taken from the Huggingface Library.Results. As a result of the study, the performance of RuBERT language model was increased using methods to reduce the size of neural networks, such as distillation of knowledge and quantization, as well as by exporting the model to ONNX format and running it in ONNX runtime.Conclusion. As a result, the model, to which knowledge distillation, quantization and ONNX optimization were simultaneously applied, received a performance increase of ~ 4.6 times (from 66.57 to 404.46 requests per minute), while the size of the model decreased ~ 13 times (from 676.29 MB to 51.66 MB). The downside of obtained performance was EM deterioration (from 61.3 to 56.87) and F-measure (from 81.66 to 76.97).
Multicriteria Optimization of Design Solutions for Microclimate Systems for Rooms with Artificial Ice
Authors: Chuykin S. V. , Kutsygina O. A. 
Published: February 2023

Рurpose of research. The most energy-intensive facilities for holding sports and cultural events are indoor ice rinks and ice arenas. Simplified technical solutions when designing the systems for providing the microclimate of these structures lead to significant operating costs and can lead to serious negative consequences in a relatively short period. In this regard, the problem of developing methods for choosing the optimal design solution for these systems is becoming ever more urgent. The purpose of the article is to develop a mathematical model for multi-criteria optimization of design solutions for systems providing the microclimate of rooms with artificial ice.Methods. Determining the optimal design solution for microclimate systems in terms of several parameters, each of which can be decisive, is an applied task of system analysis, the basic principles and patterns of which were taken into account when solving the problem of multicriteria optimization.Results. A list of particular optimality criteria reflecting the qualitative and quantitative characteristics of design solutions has been determined. The method of vector criterion convolution has been used to search for the optimal solution for the selected particular criteria. An optimization model based on the principles of system analysis has been developed.Conclusion. The developed mathematical model of multicriteria optimization makes it possible to provide priority to more important particular criteria by increasing their weights. In this case, it should be remembered that particular criteria must be commensurate, and, therefore, reduced to a dimensionless form. Since the absolute values of the criteria are essential in the optimization task under consideration, for the chosen vector of parameters, it is necessary to choose exactly the additive method of folding the generalized criterion.
Study of Vibration Strength of D16 Aluminum Alloy Joints Welded Applying Resistance Spot Welding
Authors: Balashov S. A. , Zezyulya V. V. , Bulychev V. V. , Ageeva E. V. 
Published: February 2023

Purpose of research is to develop and test a technique and perform an experimental study of the vibration strength of D16 aluminum alloy joints welded applying resistance spot welding.Methods. Test coupons were made from 1 mm thick D16 aluminum alloy sheet blanks applying resistance spot welding. A feature of the proposed test is the implementation of a symmetrical loading cycle. During the tests, the number of cycles to failure depending on the range of vibrations was recorded. Annealing and thermomechanical straightening were carried out to exclude helical bending after cutout. After deburring and root facing, the surface of the coupons was prepared for welding using chemical etching. The coupons were welded using a TECNA 8214N spot welding machine. The welding current was 30 kA, the welding duration was 0.1 s, the electrodes force was 180 daN. The static shear strength of the welded joint was studied using a UTS 110M-5 1-U tensile testing machine. The breaking force was 3.66 kN. The peculiarity of the proposed test is the implementation of a symmetrical loading cycle. During the tests, the number of cycles to failure depending on the range of vibrations was recorded.Results. As a result of the statistical analysis of the study results, a linear mathematical relationship between the logarithms of the number of cycles to failure and the amplitude of vibrations was obtained. Depending on the range of vibrations, characteristic zones of destruction were revealed. To provide the possibility of comparing the results of vibration obtained under different conditions of fixing the samples, it is proposed to use the range of vibration displacement per unit length of the work[iece as the ordinate.Conclusion. A technique or studying the vibrational strength of joints welded by resistance spot welding under conditions of a symmetrical loading cycle is proposed and tested. For the studied coupons, the equality of the welded joint to the base metal is achieved at the value of the logarithm of the ratio of the range of vibration displacement per unit length of the coupons equal to 0.01.
Indigenous Food Systems Changes and Resiliency: Protocol for a Scoping Review
Authors: Monteith Hiliary , Hiscock Elizabeth Claire , Sadeghi Yasamin , Smith Emily V , Mashford-Pringle Angela 
Published: February 2023

BackgroundIndigenous food systems (IFS) consider the complex relationships and connections between land, animals, plants, water, and people. These food systems may differ between regions, Indigenous cultures, and history; however, given the similar colonial histories and policies influencing Indigenous groups in Canada, the United States, Australia, and Aotearoa (New Zealand), the IFS changes and responses in these regions may follow similar trends. Climate change and pollution continue to impact the environment in catastrophic ways, and this, in turn, impacts IFS. However, to date, there has been no review of the literature on IFS, how they are changing, and how communities are responding to these changes.ObjectiveIn this scoping review, we will summarize primary research in Canada, the United States, Australia, and Aotearoa related to IFS addressing the following questions: (1) What changes are IFS experiencing in the context of climate change and pollution? (2) What actions have been taken in response to IFS changes? (3) What are the characteristics of IFS research in peer-reviewed academic literature?MethodsWe will use the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for scoping reviews and the Joanna Briggs Institute reviewer’s manual to inform the review process. MEDLINE, SCOPUS, International Bibliography of the Social Sciences, Sociological Abstracts, and the Bibliography of Native North Americans are the databases included in this review search. All screening and extraction have been supported by Covidence software (Veritas Health Innovation) with 2 independent reviewers conducting the abstract and full-text screening. We will map concepts and themes related to the research questions to contribute to the understanding of IFS within the academic literature and provide a narrative review of the outcomes.ResultsThe electronic database searches for this review were conducted in May 2021. Screening and full-text review were initially completed in the winter of 2022. We are currently in the process of compiling results and aim to share findings in 2023.ConclusionsThis review will provide valuable insight into current IFS needs by summarizing the peer-reviewed literature on how IFS are changing because of climate change and pollution and how communities are responding to these changes. The results of this review will be shared with Indigenous communities, through academic publications, community conversations, and conference presentations.Trial RegistrationOSF Registries osf.io/xrj87; https://osf.io/xrj87International Registered Report Identifier (IRRID)RR1-10.2196/41627
Teaching Principles of Medical Innovation and Entrepreneurship Through Hackathons: Case Study and Qualitative Analysis
Authors: Preiksaitis Carl , Dayton John R , Kabeer Rana , Bunney Gabrielle , Boukhman Milana 
Published: February 2023

Background
Innovation and entrepreneurship training are increasingly recognized as being important in medical education. However, the lack of faculty comfort with the instruction of these concepts as well as limited scholarly recognition for this work has limited the implementation of curricula focused on these skills. Furthermore, this lack of familiarity limits the inclusion of practicing physicians in health care innovation, where their experience is valuable. Hackathons are intense innovation competitions that use gamification principles to increase comfort with creative thinking, problem-solving, and interpersonal collaboration, but they require further exploration in medical innovation.

Objective
To address this, we aimed to design, implement, and evaluate a health care hackathon with 2 main goals: to improve emergency physician familiarity with the principles of health care innovation and entrepreneurship and to develop innovative solutions to 3 discrete problems facing emergency medicine physicians and patients.

Methods
We used previously described practices for conducting hackathons to develop and implement our hackathon (HackED!). We partnered with the American College of Emergency Physicians, the Stanford School of Biodesign, and the Institute of Design at Stanford (d.school) to lend institutional support and expertise in health care innovation to our event. We determined a location, time frame, and logistics for the competition and settled on 3 use cases for teams to work on. We planned to explore the learning experience of participants within a pragmatic paradigm and complete an abductive thematic analysis using data from a variety of sources.

Results
HackED! took place from October 1-3, 2022. In all, 3 teams developed novel solutions to each of the use cases. Our investigation into the educational experience of participants suggested that the event was valuable and uncovered themes suggesting that the learning experience could be understood within a framework from entrepreneurship education not previously described in relation to hackathons.

Conclusions
Health care hackathons appear to be a viable method of increasing physician experience with innovation and entrepreneurship principles and addressing complex problems in health care. Hackathons should be considered as part of educational programs that focus on these concepts.
κ-Carrageenan/Sodium Alginate: A New Synthesis Route and Rapid Adsorbent for Hydroxychloroquine Drug
Authors: Al-Hussainawy Mohammed Kassim , Al-Hayder Layth Sameer 
Published: February 2023

In recent years, the huge amounts of chemicals that are used as drugs and their derivatives have been exposed to the environment due to the COVID-19 pandemic. Some of these drugs (i.e. hydroxychloroquine (HCQ)) have a serious risk on aquatic media. In this study, carrageenan/sodium alginate (κC/Sa) was investigated as a biopolymer, environmentally friendly, and rapidly adsorbent to eliminate HCQ from its aqueous solution. The biopolymer (κC/Sa) was synthesized by free radical polymerization assisted by ultrasound in the presence of acrylic acid as cross-linkage and potassium persulfate as an initiator. The natural κC/Sa was characterized by FTIR, XRD, BET, BJH, and SEM techniques. The produced co-polymer had a mesoporous surface with high purity and significant thermal stability. The best parameters were determined to be 0.05 g biopolymer, 200 ppm initial HCQ concentration, salts, and pH = 7. The adsorption mechanism follows a pseudo second-order kinetic model, and the adsorption isotherm follows a Freundlich model, with qe reaching 89.8 mg/g at 500 ppm HCQ. Thermodynamic studies indicated that the adsorption of hydroxychloroquine drugs was an exothermic spontaneous process.
Proposal for a Maturity Continuum Model for Open Research Data
Authors: Guirlet Marielle , Bongi Gaia , Point Elise , Urvoy GrÃ©goire , Schneider RenÃ© 
Published: February 2023

As a contribution to the general effort in research to generalize and improve the practices of Open Research Data (ORD), we developed a model conceptualizing the degrees of maturity of a research community in terms of ORD. This model may be used to assess the ORD capacity or maturity level of a specific research community, to strengthen the use of standards with respect to ORD within this community, and to increase its ORD maturity level.
We present the background and our motivations for developing such an instrument as well as the reasoning leading to its design. We present its elements in detail and discuss possible applications.
Evaluation of root resorption in the lower incisors after orthodontic treatment of skeletal Class III malocclusion by three-dimensional volumetric measurement with cone-beam computed tomography
Authors: Chen Junjie , Ning Ruoyu 
Published: February 2023

ABSTRACTObjectivesTo investigate the volumetric changes of the lower incisor roots in skeletal Class III orthodontic patients with anterior crossbite after premolar extraction therapy.Materials and MethodsThirty-six adults, aged 18–28 years, had four-premolar extraction treatment. Pre- and posttreatment cone-beam computed tomography (CBCT) images were used to assess the thickness and height of alveolar bone, root volume, and length. A paired t-test was used to detect changes in root volume and length before and after treatment. Pearson's correlation analysis was applied to estimate the correlation between root volume and dentoskeletal morphology.ResultsBoth the central and lateral incisors had intrusion and tipping movement after treatment. Compared with pretreatment data, root length decreased significantly. The lingual root volume of root cervical, apical third, and the labial root volume of the root apical third decreased significantly (P &lt; .05), among which the percentage of tooth loss at the tip volume was the highest. The pretreatment height of the alveolar ridge crest, thickness of the alveolar bone, and type of incisor movement were related to the volume and length loss.ConclusionsVolume and length loss in the apical third of the lower incisor roots in skeletal Class III patients treated with a Class III bicuspid extraction pattern is common. The pretreatment height of the alveolar ridge crest, thickness of the alveolar bone, and type of tooth movement are related to the loss.