bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methods Of Teaching Islamic Values Education Amid Conflict Situation: The Case Of Bangsamoro Development Agency (BDA) In Mindanao
Authors: Lantong Abdul , Musnandar Aries , Tuya Mohalidin 
Published: February 2023

Teaching Islamic values education is considered by Muslim educators as the solution to moral crisis encountered by contemporary Muslim society including the Bangsamoro in the conflict-affected area of Mindanao, Philippines. The purpose of the present paper is to re-examine the Bangsamoro Development Agency's (BDA) methods of teaching Islamic values education among its Muslim stakeholders in Mindanao. Through the use of the qualitative method of study, like content analysis of data gathered through library research and participant observation, the researcher found out that the BDA-tasked to determine, lead and manage development projects in conflict-affected areas of Mindanao-had successfully integrated Islamic values by applying the traditional Islamic method of education such as ta'lim, tarbiyyah, and ta'dib but through the language of modern education theory, adapted to the kind of situation they are in. Instead of using Islamic terminologies as such, the BDA used such term as experiential-learning method (lecturette, workshop, reflection and demonstration, and follow-through scheme). With this, the BDA had able to play its assigned role with the acceptance of its different stakeholders including government and non-government organizations. The present Bangsamoro Autonomous Region in Muslim Mindanao (BARMM), which is established as a product of the MILF’s struggle, may also consider BDA’s experience to institutionalize its moral governance initiative to address the perceived corruption, manipulation, and ill-governance in this government.

Keywords: Bangsamoro Development Agency, teaching methods, Islamic values, Values education, Mindanao (Philippines)
A machine learning approach to predict quality of life changes in patients with Parkinson's Disease
Authors: Alexander Tyler D. , Nataraj Chandrasekhar , Wu Chengyuan 
Published: February 2023

AbstractObjectiveParkinson disease (PD) is a progressive neurodegenerative disorder with an annual incidence of approximately 0.1%. While primarily considered a motor disorder, increasing emphasis is being placed on its non‐motor features. Both manifestations of the disease affect quality of life (QoL), which is captured in part II of the Unified Parkinson's Disease Rating Scale (UPDRS‐II). While useful in the management of patients, it remains challenging to predict how QoL will change over time in PD. The goal of this work is to explore the feasibility of a machine learning algorithm to predict QoL changes in PD patients.MethodsIn this retrospective cohort study, patients with at least 12 months of follow‐up were identified from the Parkinson's Progression Markers Initiative database (N = 630) and divided into two groups: those with and without clinically significant worsening in UPDRS‐II (n = 404 and n = 226, respectively). We developed an artificial neural network using only UPDRS‐II scores, to predict whether a patient would clinically worsen or not at 12 months from follow‐up.ResultsUsing UPDRS‐II at baseline, at 2 months, and at 4 months, the algorithm achieved 90% specificity and 56% sensitivity.InterpretationA learning model has the potential to rule in patients who may exhibit clinically significant worsening in QoL at 12 months. These patients may require further testing and increased focus.
Mn3O4 Nanoshell Coated Metal–Organic Frameworks with Microenvironment‐Driven O2 Production and GSH Exhaustion Ability for Enhanced Chemodynamic and Photodynamic Cancer Therapies
Authors: Li Wenya , Li Rongtian , Ye Qiang , Zou Yiming , Lu Xing , Zhang Wenhua , Chen Jinxiang , Zhao Yinghua 
Published: February 2023

AbstractNanomedicine exhibits emerging potentials to deliver advanced therapeutic strategies in the fight against triple‐negative breast cancer (TNBC). Nevertheless, it is still difficult to develop a precise codelivery system that integrates highly effective photosensitizers, low toxicity, and hydrophobicity. In this study, PCN‐224 is selected as the carrier to enable effective cancer therapy through light‐activated reactive oxygen species (ROS) formation, and the PCN‐224@Mn3O4@HA is created in a simple one‐step process by coating Mn3O4 nanoshells on the PCN‐224 template, which can then be used as an “ROS activator” to exert catalase‐ and glutathione peroxidase‐like activities to alleviate tumor hypoxia while reducing tumor reducibility, leading to improved photodynamic therapeutic (PDT) effect of PCN‐224. Meanwhile, Mn2+ produced cytotoxic hydroxyl radicals (∙OH) via the Fenton‐like reaction, thus producing a promising spontaneous chemodynamic therapeutic (CDT) effect. Importantly, by remodeling the tumor microenvironment (TME), Mn3O4 nanoshells downregulated hypoxia‐inducible factor 1α expression, inhibiting tumor growth and preventing tumor revival. Thus, the developed nanoshells, via light‐controlled ROS formation and multimodality imaging abilities, can effectively inhibit tumor proliferation through synergistic PDT/CDT, and prevent tumor resurgence by remodeling TME.
Guidelines for Impedance Analysis of Parent Metal Anodes in Solid‐State Batteries and the Role of Current Constriction at Interface Voids, Heterogeneities, and SEI
Authors: Eckhardt Janis K. , Fuchs Till , Burkhardt Simon , Klar Peter J. , Janek Jürgen , Heiliger Christian 
Published: February 2023

AbstractImpedance spectroscopy is widely used in operando studies of solid‐state batteries for characterizing charge transport and correlating it with structural features. A typical impedance spectrum reveals, in addition to transport signals of the solid electrolyte, one or more contributions due to processes taking place at the electrode interfaces. The focus of this study is on reversible (parent) metal anodes and a 3D electric network model is used to analyze the variation of their impedance as a function of pressure, temperature, or aging during cycling. This provides a recipe for experimentalists on how to identify impedance contributions arising from different interface effects, such as, charge transfer, dynamic current constriction, and solid electrolyte interphase formation. Rules are derived for assigning the different interface signals or identifying the dominant contribution in case of similar frequency‐dependence and a standard procedure for analysis is proposed. The suggested procedure is applied to experimental data of half cells where lithium metal is in contact with garnet‐type Li6.25Al0.25La3Zr2O12. This case study yields unambiguously that geometric current constriction due to morphological instabilities at the metal anode interface during cycling is the rate‐limiting step for this type of metal anode, rather than the frequently assumed polarization resistance of the electric charge transfer migration process.
Indolizine Synthesis through Annulation of Pyridinium 1,4‐Thiolates and Copper Carbenes: A Predictive Catalysis Approach
Authors: Monreal‐Corona Roger , Díaz‐Jiménez Àlex , Roglans Anna , Poater Albert , Pla‐Quintana Anna 
Published: February 2023

AbstractPredictive catalysis was applied to the reaction of pyridinium 1,4‐zwitterionic thiolates with a copper carbene. Theoretical calculations were first performed to determine the suitability of their annulation reaction and to make predictions about the performance of different copper salts, diazo species, and pyridinium derivatives. With calculations in hand, the experimental conditions were optimized, the scope of the reaction was assessed, and the precision of the predictions was evaluated. Yields up to 90% were obtained for the synthesis of indolizine scaffolds in the reactivity of pyridinium 1,4‐zwitterionic thiolates with a metal carbene.magnified image
DABCO‐Catalysed [3+2] Cyclization/Deformylation Cascade of p‐Quinols with 3‐Formylchromones: Access to Benzopyrone‐Fused Tetracyclic Ring Systems
Authors: Liu Xiong‐Wei , Lin Xiao‐Tong , Zhao Cheng , Hu Xiao‐Wei , Xu Yi‐Bing , Zheng Yi‐Lin , Liu Xin‐Ni , Chen Guo‐Shu , Chen Long , Liu Yun‐Lin 
Published: February 2023

AbstractThe construction of benzopyrone‐fused hydrobenzofuranones via DABCO‐catalyzed [3+2] cyclization/deformylation cascade of p‐quinols with 3‐formylchromones is described. The reaction works under mild reaction conditions to provide the desired products in 53–90% yields with complete diastereoselectivities. In addition, an enantioselective version with 81% ee is also realized in the presence of Takemoto's chiral thiourea catalyst.magnified image
More Chips to Nitroolefins: Decatungstate Photocatalysed Hydroalkylation Under Batch and Flow Conditions
Authors: Jorea Alexandra , Bassetti Benedetta , Gervasoni Klaus , Protti Stefano , Palmieri Alessandro , Ravelli Davide 
Published: February 2023

AbstractThe hydroalkylation of nitroalkenes and β‐nitroacrylates via a photocatalytic strategy has been optimised under both batch and continuous flow conditions. This target has been achieved by exploiting the potentialities of the decatungstate anion as a versatile hydrogen atom transfer (HAT) photocatalyst for the generation of alkyl radicals from aliphatic heterocycles, amides and cycloalkanes.magnified image
Chinese expert consensus on antithrombotic management of high‐risk elderly patients with chronic coronary syndrome
Authors: Zhang Cuntai , Wang Xiaoming ,   Cardiovascular Group, Geriatrics Branch of Chinese Medical Association
Published: February 2023

AbstractThe prevalence and mortality of coronary artery disease (CAD) in China are still at an increasing stage. CAD can be classified as acute coronary syndrome (ACS) or chronic coronary syndrome (CCS). CCS is the main manifestation type of elderly patients with CAD, with a large number of patients, long course of disease, and poor prognosis, leading to decreased quality of life and heavy disease burden and economic burden. Especially in patients with high‐risk CCS, the case fatality rate and total mortality are high. In order to better standardize the antithrombotic treatment of elderly patients with high‐risk CCS, the Geriatrics Branch of the Chinese Medical Association organizes domestic experts to develop this consensus for clinicians' reference based on published clinical research evidence, combined with relevant guidelines, consensus, and expert recommendations in China and abroad.
Hydroxylation with Unusual Stereoinversion Catalyzed by an FeII/2‐OG Dependent Oxidase and 3,6‐Diene‐2,5‐diketopiperazine Formation in the Biosynthesis of Brevianamide K
Authors: Xu Zhuo‐Zheng , Zhuang Zheng , Cai Runlin , Lin Guo‐Qiang , She Zhigang , Zhao Qunfei , He Qing‐Li 
Published: February 2023

AbstractNatural products with the 3,6‐diene‐2,5‐diketopiperazine core are widely distributed in nature; however, the biosynthetic mechanism of 3,6‐diene‐2,5‐diketopiperazine in fungi remains to be further elucidated. Through heterologous expression and biochemical investigation of an FeII/2‐oxoglutarate‐dependent oxidase (AspE) and a heme‐dependent P450 enzyme (AspF), we report that AspE, AspF and subsequent dehydration account for the formation of the 3,6‐diene‐2,5‐diketopiperazine substructure of brevianamide K from Aspergillus sp. SK‐28, a symbiotic fungus of mangrove plant Kandelia candel. More interestingly, in‐depth investigation of the enzymatic mechanism showed that AspE promotes hydroxylation of brevianamide Q with unprecedented stereoinversion through hydrogen atom abstraction and water nucleophilic attack from the opposite face of the resultant iminium cation intermediate.
Precise Synthesis of ChiralZ‐Allylamides by Cobalt‐Catalyzed Asymmetric Sequential Hydrogenations
Authors: Hu Yanhua , Zou Yashi , Yang Huiwen , Ji Haotian , Jin Yue , Zhang Zhenfeng , Liu Yangang , Zhang Wanbin 
Published: February 2023

AbstractAsymmetric sequential hydrogenations of conjugated enynes have been developed using a Ph‐BPE‐CoIcatalyst for the precise synthesis of chiralZ‐allylamides in high activity (up to 1000 substrate/catalyst (S/C)) and with excellent enantioselectivity (up to >99 % enantiomeric excess (ee)). Mechanism experiments and theoretical calculations support a cationic CoI/CoIIIredox catalytic cycle. The catalytic activity difference between cobalt complexes of Ph‐BPE and QuinoxP* was explained by the process decomposition of rate‐determining step in the second hydrogenation.
Ein vierfacher Gold(I)−Aryl‐Makrozyklus mit hyperbolischer Geometrie und dessen reduktive Eliminierung zu einem Kohlenstoffnanoring‐Wirt
Authors: Grabicki Niklas , Fisher Sergey , Dumele Oliver 
Published: February 2023

AbstractEin Ethylenglykol‐dekorierter [6]Cyclo‐meta‐phenylen(CMP)‐Makrozyklus wurde hergestellt und als Untereinheit für den Aufbau eines vierfachen AuI2−Aryl‐Metallazyklus mit einer quadratischen Überstruktur genutzt. Die Ecken bestehen aus dinuklearen Gold(I)‐Komplexen, von denen bisher nur dreieckige Metallazyklen bekannt waren. Das Zusammenspiel von flexibler Konformation des [6]CMP‐Makrozyklus und der starren dinuklearen Gold(I)‐Einheit ermöglicht die quadratische Geometrie, die durch Kristallstrukturanalyse charakterisiert wurde. Die Bildung des Goldkomplex läuft im Vergleich zu einer alternativen Routen über Platin(II)‐Ecken größenselektiv ab. Durch reduktive Eliminierung wird ein vollständig organischer Ether‐dekorierter Kohlenstoffnanoring erhalten. Dieser wurde als Wirt zur Komplexierung von großen Gastmolekülen mit geeigneter konvexer π‐Oberfläche mittels isothermer NMR‐Bindungstitration untersucht. Die Assoziationskonstanten für [6]Cycloparaphenylen ([6]CPP), [7]CPP, C60 und C70 wurden bestimmt.
Dithienylethene‐Based Single Molecular Photothermal Linear Actuator
Authors: Rashid Umar , Chatir Elarbi , Medrano Sandonas Leonardo , Sreelakshmi PA , Dianat Arezoo , Gutierrez Rafael , Cuniberti Gianaurelio , Cobo Saioa , Kaliginedi Veerabhadrarao 
Published: February 2023

AbstractBy employing a mechanically controllable break junction technique, we have realized an ideal single molecular linear actuator based on dithienylethene (DTE) based molecular architecture, which undergoes reversible photothermal isomerization when subjected to UV irradiation under ambient conditions. As a result, open form (compressed, UV OFF) and closed form (elongated, UV ON) of dithienylethene‐based molecular junctions are achieved. Interestingly, the mechanical actuation is achieved without changing the conductance of the molecular junction around the Fermi level over several cycles, which is an essential property required for an ideal single molecular actuator. Our study demonstrates a unique example of achieving a perfect balance between tunneling width and barrier height change upon photothermal isomerization, resulting in no change in conductance but a change in the molecular length, which results in mechanical actuation at the single molecular level.
Tailor‐Made PdnL2n Metal‐Organic Cages through Covalent Post‐Synthetic Modification
Authors: Luo Dong , Yuan Zi‐Jun , Ping Lin‐Jie , Zhu Xiao‐Wei , Zheng Ji , Zhou Chuang‐Wei , Zhou Xian‐Chao , Zhou Xiao‐Ping , Li Dan 
Published: February 2023

AbstractPost‐synthetic modification (PSM) is an effective approach for the tailored functionalization of metal‐organic architectures, but its generalizability remains challenging. Herein we report a general covalent PSM strategy to functionalize PdnL2n metal‐organic cages (MOCs, n=2, 12) through an efficient Diels–Alder cycloaddition between peripheral anthracene substituents and various functional motifs bearing a maleimide group. As expected, the solubility of functionalized Pd12L24 in common solvents can be greatly improved. Interestingly, concentration‐dependent circular dichroism and aggregation‐induced emission are achieved with chiral binaphthol (BINOL)‐ and tetraphenylethylene‐modified Pd12L24, respectively. Furthermore, Pd12L24 can be introduced with two different functional groups (e.g., chiral BINOL and achiral pyrene) through a step‐by‐step PSM route to obtain chirality‐induced circularly polarized luminescence. Moreover, similar results are readily observed with a smaller Pd2L4 system.
Enzyme Translocation‐Mediated Signal Amplification for Spatially Selective Aptasensing of ATP in Inflammatory Cells
Authors: Sheng Chuangui , Zhao Jian , Yu Fangzhi , Li Lele 
Published: February 2023

AbstractAmplified ATP imaging in inflammatory cells is highly desirable. However, the spatial selectivity of current amplification methods is limited, that is, signal amplification is performed systemically and not in a disease site‐specific manner. Here we present a versatile strategy, termed enzymatically triggerable, aptamer‐based signal amplification (ETA‐SA), that enables inflammatory cell‐specific imaging of ATP through spatially‐resolved signal amplification. The ETA‐SA leverages a translocated enzyme in inflammatory cells to activate DNA aptamer probes and further drive cascade reactions through the consumption of hairpin fuels, which, however, exerts no ATP response activity in normal cells, leading to a significantly improved sensitivity and spatial specificity for the inflammation‐specific ATP imaging in vivo. Benefiting from the improved spatial selectivity, enhanced signal‐to‐background ratios were achieved for ATP imaging during acute hepatitis.
Electrophilically Trapping Water for Preventing Polymerization of Cyclic Ether Towards Low‐Temperature Li Metal Battery
Authors: Jiang Hai‐Zhen , Yang Chao , Chen Min , Liu Xiao‐Wei , Yin Lu‐Ming , You Ya , Lu Jun 
Published: February 2023

AbstractCyclic ether, such as 1,3‐dioxolane (DOL), are promising solvent for low‐temperature electrolytes because of the low freezing point. Their use in electrolytes, however, is severely limited since it easily polymerizes in the presence of lithium inorganic salts. The trace water plays a key role via providing the source (proton) for chain initiation, which has, unfortunately, been neglected in most cases. In this work, we present an electrophile, trimethylsilyl isocyanate (Si−NCO), as the water scavenger, which eliminates moisture by a nucleophilic addition reaction. Si−NCO allows DOL to maintain liquid over a wide temperature range even in high‐concentration electrolyte. Electrolyte with Si−NCO additive shows promising low‐temperature performance. Our finding expands the use of cyclic ether solvents in the presence of inorganic salts and highlights a large space for unexplored design of water scavenger with electrophilic feature for low‐temperature electrolytes.
P3HTandPEDOT:PSSprinted thin films on chemiresistors: An economic and versatile tool for ammonia and humidity monitoring applications
Authors: Kumpf Katarina , Trattner Stephan , Aspermair Patrik , Bintinger Johannes , Fruhmann Philipp 
Published: February 2023

AbstractWe hereby present the fabrication of simple and efficient humidity and ammonia sensors based on a chemiresistor design employing a differential measurement technique. Interdigitated electrodes are connected via PEDOT:PSS or P3HT polymers and a reproducible and scalable fabrication procedure is presented. This procedure utilizes pneumatic nozzle printing instead of drop or spin‐based processes and includes an optimized encapsulation procedure and material for sealing the reference electrodes. The suitability of the NH3sensor for quantifying ammonia in a range of 2 to 100 ppm within a period of several months is furthermore presented. The developed humidity sensor is operational for several months in a humidity range between 10 and 60% RH. Once this range is exceeded, a sensor decay by irreversible saturation can be observed. Based on the low fabrication costs of the sensors (~0.5 $ when ordering 1000 pcs of the platform + printing work), they provide a very attractive tool for industrial humidity and ammonia sensing applications.
Alpha tensor and dynamo excitation in turbulent fluids with anisotropic conductivity fluctuations
Authors: Gressel Oliver , Rüdiger Günther , Elstner Detlef 
Published: February 2023

AbstractA mean‐field theory of the electrodynamics of a turbulent fluid is formulated under the assumption that the molecular electric conductivity is correlated with the turbulent velocity fluctuation in the (radial) direction, . It is shown that for such homogeneous fluids a strong turbulence‐induced field advection anti‐parallel to arises almost independently of rotation. For rotating fluids, an extra effect appears with the known symmetries and with the expected maximum at the poles. Fast rotation, however, with Coriolis number exceeding unity suppresses this term. Numerical simulations of forced turbulence using the nirvana code demonstrate that the radial advection velocity, , always dominates the term. We show finally with simplified models that dynamos are strongly influenced by the radial pumping: for the solutions become oscillatory, while for they become highly exotic if they exist at all. In conclusion, dynamo models for slow and fast solid‐body rotation on the basis of finite conductivity–velocity correlations are unlikely to work, at least for dynamos without strong shear.
μ‐opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway: a comprehensive study including randomized controlled trial
Authors: Wang Xiaoqiang , Zhang Song , Jin Di , Luo Jiamei , Shi Yumiao , Zhang Yiqi , Wu Lingling , Song Yanling , Su Diansan , Pan Zhiying , Chen Haige , Cao Ming , Yang Chaoyong , Yu Weifeng , Tian Jie 
Published: February 2023

AbstractBackgroundμ‐opioid receptor agonists (MORAs) are indispensable for analgesia in bladder cancer (BC) patients, both during surgery and for chronic pain treatment. Whether MORAs affect BC progression and metastasis remains largely unknown. This study focused on the effects of MORAs on the formation of circulating tumor cells (CTCs) in BC and aimed to provide potential therapeutic targets, which would retain the pain‐relieving effects of MORAs in BC patients without sacrificing their long‐term prognosis.MethodsDifferent preclinical models were used to identify the effects of MORAs on the progression of BC. A novel immunocapture microfluidic chip was utilized to analyze whether MORAs affected the number of CTCs in mouse models and clinical BC patients. Bioinformatic analyses, total transcriptome sequencing, and molecular biology methods were then used to investigate the underlying mechanisms in these models and in BC cell lines.ResultsMouse models of hematogenous metastasis and in situ BC demonstrated that tumor metastasis was significantly increased after MORA treatment. A significant increase in the number of mesenchymal and/or epithelial CTCs was detected after MORA treatment in both the mouse models and clinical trial patients. Mechanistically, MORAs facilitated the formation of CTCs by activating the MOR/PI3K/AKT/Slug signaling pathway, hereby promoting the epithelial‐mesenchymal transition (EMT) of BC cells, as knockdown of MOR, Slug or blockade of PI3K inhibited the EMT process and CTC formation.ConclusionMORAs promoted BC metastasis by facilitating CTC formation. The EMT‐CTC axis could be targeted for preventive measures during MORA treatment to inhibit the associated tumor metastasis or recurrence in BC patients.