bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involvement of neuropeptidergic neurons in the establishment of dominance in a teleost model of non-breeding aggression: neuropeptide-specific and status-dependent actions
Authors: Pouso Paula , Cabana Álvaro , Francia Virginia , Silva Ana 
Published: January 2023

Abstract
The establishment of the dominant-subordinate status implies a clear behavioral asymmetry between contenders that arises immediately after the resolution of the agonistic encounter and persists during the maintenance of stable dominance hierarchies. Changes in the activity of the brain social behavior network (SBN) are postulated to be responsible for the establishment and maintenance of the dominant-subordinate status. The hypothalamic nonapeptides of the vasopressin/vasotocin (AVP/AVT) and oxytocin/mesotocin/isotocin (OXT/MST/IT) family are known to modulate the activity of the SBN in a context-dependent manner across vertebrates, including status-dependent modulations. We searched for status-dependent asymmetries in AVT/IT cell number and activation immediately after the establishment of dominance in the weakly electric fish, Gymnotus omarorum, which displays the best understood example of non-breeding territorial aggression among teleosts. We used immunolabeling (FOS, AVT, and IT) of preoptic area (POA) neurons after careful designed intermale dyadic agonistic encounters. We show for the first time in teleosts, that AVT, but not IT, is involved in the establishment of the dominant-subordinate status. We also found status-dependent POA subregion-specific changes of AVT cell number and activation that confirm the involvement of AVT in the establishment of dominance likely achieved by the release of AVT from dominants’ AVT neurons.
On the Dotsenko-Fateev complex twin of the Selberg integral and its extensions
Authors: Neretin Yury 
Published: January 2023

Abstract
The complex Dotsenko-Fateev integral In(σ; τ ; θ) is the Selberg beta integral, where real variables in the integrand ∏|xk | σ-1 |1- xk | τ-1 ∏| xk-x1|2θ are replaced by complex variables and an integration over a cube is replaced by
an integration over the whole Cn. According Dotsenko, Fateev, and Aomoto, such integral is a product of Gamma functions. We dene a family of beta integrals over spaces Cm × Cm+1 × ...× Cn, which for m = n gives the integral In (with three additional integer parameters.
Systemic steroid therapy for pneumonic chronic obstructive pulmonary disease exacerbation: A retrospective cohort study
Authors: Shiroshita Akihiro , Anan Keisuke , Takeshita Masafumi , Kataoka Yuki 
Published: January 2023

Abstract
The effectiveness of systemic steroid therapy on mortality in patients with pneumonic chronic obstructive pulmonary disease (COPD) exacerbation is unclear. We evaluated the association between systemic steroid therapy and 30-day mortality after adjusting for known confounders, using data from the Health, Clinic, and Education Information Evaluation Institute in Japan, which longitudinally followed-up patients in the same hospital. We selected patients aged ≥ 40 years admitted for pneumonic chronic obstructive pulmonary disease (COPD) exacerbation. The exclusion criteria were censoring within 24 h, comorbidity with other respiratory diseases, and daily steroid use. Systemic steroid therapy was defined as oral/parenteral steroid therapy initiated within two days of admission. The primary outcome was the 30-day mortality. To account for known confounders, each patient was assigned an inverse probability of treatment weighting. The outcome was evaluated using logistic regression. Among 3,662 patients showing pneumonic COPD exacerbation, 30-day mortality in the steroid therapy and non-steroid therapy groups was 27.6% (169/612) and 21.9% (668/3,050), respectively. Systemic steroid therapy indicated a slightly higher estimated probability of 30-day mortality (difference in the estimated probabilities, 3.59%; 95% confidence interval: -0.36–7.54%). Systemic steroid therapy within two days of admission was associated with higher 30-day mortality rates in pneumonic COPD exacerbation.
Characteristics of Coronary Artery Ectasia and Accompanying Plaques: An Optical Coherence Tomography Study
Authors: yu huai , Dai jiannan , tang hao , fang chao , jiang senqing , tu yingfeng , yu bo 
Published: January 2023

Abstract
Objective
Coronary artery ectasia (CAE) in adults is often caused by atherosclerotic plaques. CAE can affect atherosclerotic plaques through hemodynamic changes. However, no study has evaluated the characteristics of CAE with atherosclerotic plaques. Therefore, we aimed to disclose the characteristics of atherosclerotic plaques in patients with CAE using optical coherence tomography (OCT).
Methods and results
We evaluated patients with CAE, confirmed by coronary angiography, who underwent pre-intervention OCT between April 2015 and April 2021. Each millimeter of the OCT images was analyzed to assess the characteristics of CAEs, plaque phenotypes, and plaque vulnerability. A total of 286 patients (344 coronary vessels) met our criteria, 82.87% of whom were men. Right coronary artery lesions were the most common, comprising 44.48% (n = 153) of the total. We found 329 CAE vessels with plaques, accounting for 95.64% of the coronary vessels. After grouping CAEs and plaques by their relative positions, we found that the length of plaques within CAE lesions was longer than that of plaques in other sites (P < 0.001). Plaques within CAE lesions had greater maximum lipid angles and lipid indexes (P = 0.007, P = 0.004, respectively) than those on other sites.
Conclusions
This study revealed the most common vascular and morphological characteristics of CAE. While the accompanying plaques were not affected by the location or morphology of the CAE vessels, they were affected by their position relative to the CAE lesion.
The Impact of Dominant Ventricular Morphology on the Early Postoperative Course after the Glenn Procedure
Authors: Keizman Eitan , Abarbanel Inbar , Salem Yishai , Mishaly David , Serraf Alain E. , Pollak Uri 
Published: January 2023

Abstract
The dominant ventricular morphology affects both the early and late outcomes of the Fontan procedure, but its impact on the patients’ status immediately following the Glenn procedure is unknown. This study aimed to evaluate the effect of the infants' dominant ventricular morphology on the immediate course after undergoing the Glenn procedure. This single-center, retrospective study included all patients who underwent the Glenn procedure between October 2003 and May 2016. The patients were divided into two groups according to their dominant ventricular morphology. Their postoperative records were reviewed and compared. Out of the 89 patients who underwent the Glenn procedure during the study period, 40 (44.9%) had dominant right ventricular morphology and 49 (55.1%) had left ventricular morphology. There were no significant group differences in baseline characteristics or operative data. The maximal postoperative vasoactive-inotropic score was significantly higher and the extent of ventricular dysfunction was significantly more severe in the dominant right ventricle group (P < 0.05). The length of hospitalization was slightly but not significantly longer in the hypoplastic LV group. It is concluded that a dominant LV morphology has superior ventricular function and requires less inotropic support compared to a dominant RV morphology in the immediate postoperative course following the Glenn procedure, although overall survival was not affected by these differences. Further study to determine the pathophysiologic basis for these differences is warranted.
Focused beam self-cleaning during laser filamentation
Authors: Pushkarev Dmitrii V. , Rizaev Georgy E. , Mokrousova Daria V. , Gavrilov Sergey Yu. , Levus Maximilian V. , Mitricheva Elizaveta S. , Seleznev Leonid V. , Ionin Andrey A. 
Published: January 2023

Abstract
The beam self-cleaning phenomenon is theoretically predicted by the two-dimensional nonlinear Schrödinger equation, which describes self-focusing, and is observed in the case of femtosecond laser filamentation in the collimated regime of propagation. However, the impact of external focusing on the self-cleaning has not been investigated so far. In this paper we systematically study this impact in a wide range of focusing conditions. We show that the energy range, in which self-cleaning can be observed, shrinks monotonically with the numerical aperture growth at some point vanishing at all.
Boundedness in a higher-dimensional singular chemotaxis-growth system with indirect signal production *
Authors: Liu Chao , Ren Guoqiang , Liu Bin 
Published: January 2023

Abstract
In this paper, we consider a higher-dimensional singular chemotaxis-growth system with indirect signal production. Under appropriate regularity assumption on the initial data, the global boundedness of classical solution is obtained. Our results improve and complement previously known ones.
Resolving the Transportation Problem with Hexagonal Intuitionistic Fuzzy Numbers
Authors: N karthikeyan , R Srinivasan , Mohammad Esmael Samei 
Published: January 2023

Abstract
Fuzzy numbers play crucial roles in topics relating to dynamics, information analysis, and economics strategy. A necessary advancement in many numerical models is finding the Positioning of many fuzzy numbers. The optimal result for the transportation problems was generated using a Fuzzy number of offered techniques. We alter the Hexagonal Intuitionistic Fuzzy transportation problem to a dazzling esteemed one in this paper’s proposed positioning strategy, which is then applied to another recommended interaction to find the Fuzzy reasonable arrangement. The statistical illustration demonstrates the new proposed method’s delicate and wonderful approaches to handling the transportation challenges based on fuzzy calculations.
(2010) Mathematics Subject Classifications: 34C10, 34K11, 34K40, 39A10.
Epithelial tumors of the thymus with pleural dissemination: the potential role of surgery
Authors: Pikin O. V. , Ryabov A. B. , Aleksandrov O. A. , Kolbanov K. I. , Glushko V. A. , Barmin V. V. , Bagrov V. A. , Martynova D. E. 
Published: January 2023

Background. Pleural metastases of thymic epithelial tumors are detected in 5–7 % of patients at initial diagnosis and in 10 % of patients during a follow-up after radical surgery for the primary tumor. Partial pleuroectomy is the cornerstone of treatment strategy in this group of patients.The aim of the study was to assess the role of surgery in the treatment of patients with thymic epithelial tumors with pleural dissemination.Material and Methods. From January1, 2010 to June 30, 2021, 21 patients with thymic epithelial tumors (thymoma – 13, thymic cancer – 8) and pleural implants (stage IVA – 11, isolated pleural metastases as tumor progression after radical surgery – 10) underwent partial pleuroectomy with resection of the diaphragm and lung if necessary. Four patients underwent inthraoperative photodynamic therapy and another 4 patients received intrapleural hyperthermic chemotherapy.Results. R0 resection was performed on 12 (57.2 %) patients. Postoperative complications were observed in 6 (28.6 %) patients. The mortality rate was 7.5 %. The overall 1-, 3- and 5-year survival rates were 78 % (95 % CI 61–95), 49 % (95 % CI 23–75), and 41 % (95 % CI 15–67), respectively. The median overall survival time was 29 months (95 % CI 0–60.6). Recurrence occurred in 10 (47.6 %) cases. One-year recurrence-free survival was 60 % (95 % CI 30–90). Independent negative predictors for overall survival were: thymic cancer, incomplete resection, presence of postoperative complications and local recurrence.Conclusion. Surgery is the mainstay of treatment for patients with pleural metastases (stage IVA thymomas and recurrent thymomas). Metastasectomy of pleural implants will be suffcient to achieve a complete resection.
Microbiome, immune system and cancer: three sides of the one medal
Authors: Belyavskaya V. A. , Cherdyntseva N. V. , Kzhyshkovska J. G. , Litvyakov N. V. 
Published: January 2023

Purpose of the study to analyze current ideas about the relationship between the microbiota (microbiome) and the human body in the aspect of cancer pathogenesis, ambivalent character of these interactions, and the role of the immune system and immunoinfammatory status that promotes carcinogenesis or prevents neoplastic processes.Material and Methods. Literature search was carried out using Medline, Cochrane Library, Elibrary and PubMed systems, including publications over the last 7 years.Results. The microbiota includes all communities of commensal, symbiotic, and pathogenic microorganisms: bacteria, fungi, archaea, and viruses that colonize the gastrointestinal tract and other organs and tissues. The microbiome is an important factor in cancer pathogenesis due to its involvement in the basic physiological functions of the host, such as digestion, development of the immune system, and modulation of endocrine functions. In the review, the influence of microbiota of different locations (gastrointestinal tract, breast, intravaginal tract) on the development and progression of breast, colorectal and cervical cancers was discussed. The role of the microbiome in cancer pathogenesis is realized by the participation in neoplastic transformation of the epithelium, regulation of tumor progression under conditions of manifested malignant process, and modifcation of the therapeutic effect of standard drugs, including the development of original probiotic-based anticancer agents. The study of the mechanisms of action of the microbiome in the host organism opens up prospects for the development of new approaches to cancer therapy. Particular attention was paid to the mechanisms of the immunomodulatory effect of the microbiota in terms of reducing the risk of malignancy, regulating tumor progression and participating in antitumor therapy. The clinical significance of determining pathogenetically significant microbial markers associated with the aggressive form of cancer, response to treatment and toxicity of therapy was discussed. Particular attention should be paid to the potential mechanisms of interaction between cancer – microbiome – probiotics, since the latter can provide modification of malignancy processes, exert an antitumor effect, and modulate the effectiveness of drug therapy. The feasibility of editing the microbiota by probiotics was considered, and antitumor properties (effects) of bacteria and strategies for modifying the microbiome for the prevention and treatment of cancer were discussed.
Glycodelin is a potential biomarker for malignant tumors
Authors: Mnikhovich M. V. , Shekhter M. A. , Bezuglova T. V. , Skafi K. Kh. , Artemyeva K. A. , Mishina E. S. 
Published: January 2023

Objective of the study to analyze and summarize the available data on the role of glycodelin in carcinogenesis and its expression in various cancers.Material and Methods. A literature search was conducted in Medline, PubMed Central, NCBI databases in the time interval from January 1983 to October 2019 using the key words glycodelin and cancer. Of the 104 publications found, 21 were used to write the review.Results. This paper presents the overview of the findings in current research focusing on the properties of glycodelin, the major lipocalin protein of the human reproductive system. Some lipocalins are known to play a key role in cancer development as well as influence signaling pathways in the regulation of cell motility, differentiation and neovascularization. Most likely they can be used as cancer markers. Glycodelin A is determined in serum and, due to its special immunoregulatory properties, can serve as a useful prognostic marker and a promising target for future anti-cancer therapies. The presence of glycodelin A in breast cancer tissue is known to be mostly linked to a better prognosis than is attributed to glycodelin-negative tissue, as glycodelin is a protein typical of differentiated tissue. On the other hand, glycodelin might play a role in neovascularisation, thereby promoting tumor growth. Glycodelin is a biomarker of aggressive malignant pleural mesothelioma and a prognostic biomarker of metastatic non-small cell lung cancer at late stages. Glycodelin hyperexpression is associated with brain metastasis in lung adenocarcinoma, and its determination can be used as an additional prognostic factor.Conclusion. The review refects basic scientifc data and results of clinical trials, as well as identifes future prospects that allow the development of new methods for cancer detection and treatment. It should be noted that glycodelin plays an important role in tumor development, progression, angiogenesis, and the formation of distant metastases, and therefore can serve as a useful diagnostic and prognostic marker. Further studies of the functional properties of glycodelin are needed to develop promising strategies in cancer therapy.
Efficacy of preoperative therapy in patients with high and low risk of distant metastasis in non-small cell lung cancer
Authors: Pankova O. V. , Tashireva L. A. , Rodionov E. O. , Мiller S. V. , Gerashchenko T. S. , Pismenny D. S. , Zavyalova M. E. , Denisov E. V. , Perelmuter V. M. 
Published: January 2023

Background. To select the optimal treatment for non-small cell lung cancer (NSCLC), it is important to predict the risk of distant metastasis and the effectiveness of therapy. The effect of neoadjuvant chemotherapy (NAC) on distant metastasis remains poorly understood. In this study we evaluated the feasibility of predicting the risk of distant metastasis and effectiveness of various treatment options for pre- and intraoperative therapy in NSCLC patients with high and low risk of distant metastasis, divided based on the assessment of morphological changes in the epithelium of small bronchi located near the primary tumor.Material and Methods. The study included 171 patients with NSCLC (T1-4N0-3M0). Various premalignant lesions: isolated basal cell hyperplasia (BCH+SM-D-), basal cell hyperplasia with squamous cell metaplasia (BCH+SM+D-) and squamous cell metaplasia with dysplasia (BCH-SM+D+) were identified in the bronchial epithelium of small bronchi taken at a distance of 3–5 cm from the tumor. Preliminary studies have shown that the detection of BCH+SM-D- or BCH-SM+D-in small bronchi are the markers of high risk of NSCLC distant metastasis, and the detection of BCH+SM+D- and BCH-SM-D- are the markers of low risk of NSCLC distant metastasis. 52.6 % of patients (90/171) received 2–3 courses of neoadjuvant chemotherapy (NAC), 41.1 % (37/90) of patients underwent intraoperative radiation therapy (IORT) at a single dose of 10–15 Gy and 47.4 % (81/171) of patients received platinum-based adjuvant chemotherapy (AC).Results. Both treatment options (NAC+IORT+ and NAC+IORT–) effectively reduced the incidence of distant metastases in the high-risk group patients during the first 2 years of follow-up compared with the high-risk group patients who did not received therapy. In the low-risk group patients, distant metastases rarely occurred, regardless of the treatment option. Adjuvant chemotherapy was found to have no influence on the frequency of distant metastases. Metastasis-free and overall survival rates were better in the low-risk group patients or in patients who received the NAC+IORT+ regimen.Conclusion. Combination of NAC and IORT resulted in the increase in metastasis-free and overall survival rates.
Genetic features of cancer of unknown primary
Authors: Schegoleva A. A. , Tretyakova M. S. , Vorobyov R. S. , Ananina O. A. , Bokova U. A. , Denisov E. V. 
Published: January 2023

Background. Cancer of unknown primary (CUP) is a metastatic lesion with diffcult identifcation of the primary tumor site using standard diagnostic approaches. Although the incidence of CUP is not high, this type of cancer often shows a high aggressiveness and therapy resistance and results in poor patient survival. The mechanisms of CUP origin are not clear, and further studies are needed.This study aims to analyze the mutational landscape of CUP and identify specifc genetic alterations.Material and Methods. Whole exome sequencing was used to analyze the mutational landscape of CUP. Results. CUP had single nucleotide variants (SNVs) in the EPHA8 (ephrin receptor) gene. CUP also harbored copy number variations (CNAs) in the ID2, FOXD4, ZMYND11, ZNF596, KIDINS220, LRRN1, GEMIN4, CEP72, TPPP, and MXRA5 genes. According to functional enrichment analysis, these genes are involved in the regulation of transcription, biogenesis of microRNA, cellular cytoskeleton, adhesion, extracellular matrix remodeling, proliferation, apoptosis, and epithelial-mesenchymal transition.Conclusion. Cancer of unknown primary harbors mutations in the genes that regulate different biological processes particularly cell motility.
Myeloid-derived suppressor cells in multiple myeloma patients at the immune recovery and after high-dose chemotherapy and hematopoietic stem cell transplantation
Authors: Tyrinova T. V. , Batorov E. V. , Aristova T. A. , Ushakova G. Yu. , Sizikova S. A. , Denisova V. V. , Ostanin A. A. , Chernykh E. R. 
Published: January 2023

Introduction. Myeloid-derived suppressor cells (MDSCs) play an important role in restriction of the immune response and are associated with a poor prognosis in cancer. Mobilization of hematopoietic stem cells (HSCs) before high-dose chemotherapy (HCT) with autologous HSC transplantation (auto-HSCT) is accompanied by a signifcant increase in MDSC counts in peripheral blood and apheresis product of multiple myeloma (MM) patients. However, quantitative changes of these cells at the post-transplant and their role at the immune recovery remain unexplored.The study was aimed to analyze the dynamics of circulating MDSC counts and the expression of suppressor molecule arginase-1 in patients with MM in the frst 12 months after HCT and auto-HSCT and evaluate association between MDSCs and transplantation outcomes.Material and Methods. The study included 44 MM patients who underwent HCT and auto-HSCT. The relative number of granulocytic MDSCs (G-MDSCs), monocytic MDSCs (M-MDSCs), and early-stage MDSCs (E-MDSCs), as well as the expression of arginase-1 in each of MDSC subsets was evaluated by fow cytometry in patient peripheral blood samples.Results. At the engraftment (day +12 – +16, leukocytes >1×109 /l), M-MDSC relative count was increased (pU=0.038), as well as the relative (pU=0.003) and absolute (pU˂0.0001) counts of G-MDSCs, decreasing after 6 months down to pre-transplant values (рU=0.007, рU=0.024 and рU=0.02, respectively) and remaining at the same level at the 12-month follow-up period. The absolute count of E-MDSCs by the time of the engraftment decreased transiently (pU=0.004 vs before HCT), gradually recovering by 12-month follow-up (pU=0.032 vs day +12 – +16). The remission within 12 months in the group with G-MDSCs˂0.17 % at the engraftment was observed in 67 ± 11 % of patients, with G-MDSCs >0.17 % – in 94 ± 6 % of patients (p=0.049). During the 12-month post-transplant, the number of M-MDSCs expressing arginase-1 has been increasing, with a tendency to lower values at the engraftment in patients with early MM relapse (pU=0.09).Conclusion. The association of early MM relapse after auto-HSCT with the lower count of G-MDSCs and the lower count of arginase-1+ M-MDSCs at the engraftment suggests that MDSCs is involved in the restriction of homeostatic proliferation as a factor for more effective immune recovery.