bluuebunny/crossref_metadata_2025_split huggingface dataset:
α1-Adrenoceptor agonist methoxamine inhibits base excision repair via inhibition of apurinic/apyrimidinic endonuclease 1 (APE1)
Authors: Kohutova Aneta , Münzova Dita , Pešl Martin , Rotrekl Vladimir 
Published: June 2023

Abstract
Methoxamine (Mox) is a well-known α1-adrenoceptor agonist, clinically used as a longer-acting analogue of epinephrine. 1R,2S-Mox (NRL001) has been also undergoing clinical testing to increase the canal resting pressure in patients with bowel incontinence. Here we show, that Mox hydrochloride acts as an inhibitor of base excision repair (BER). The effect is mediated by the inhibition of apurinic/apyrimidinic endonuclease APE1. We link this observation to our previous report showing the biologically relevant effect of Mox on BER – prevention of converting oxidative DNA base damage to double-stranded breaks. We demonstrate that its effect is weaker, but still significant when compared to a known BER inhibitor methoxyamine (MX). We further determined Mox’s relative IC
50 at 19 mmol L−1, demonstrating a significant effect of Mox on APE1 activity in clinically relevant concentrations.
Adverse drug reactions in the ambulatory internal patients at the emergency department: Focus on causality assessment and drug-drug interactions
Authors: Verbič Matej Dobravc , Brvar Miran , Kos Mojca Kerec 
Published: June 2023

Abstract
A non-interventional retrospective study in ambulatory patients was conducted at the emergency department of the Division of internal medicine. In 2 months, 266 suspected adverse drug reactions (ADRs) were identified in 224/3453 patients (6.5 %). In 158/3453 patients (4.6 %), an ADR was the reason for emergency department visit and in 49 patients (1.4 %), ADRs led to hospitalisation. A causality assessment algorithm was developed, which included Naranjo algorithm and levels of ADR recognition by the treating physician and the investigators. Using this algorithm, 63/266 ADRs (23.7 %) were classified as “certain”, whereas using solely the Naranjo score calculation, only 19/266 ADRs (7.1 %) were assessed as “probable” or “certain”, and the rest of ADRs (namely, 247/266 = 92.9 %) were assessed as “possible”. There were 116/266 (43.6 %) ADRs related to potential drug-drug interactions (DDIs), stated in at least one of the literature sources used. Based on the causality relationship, the rate of the clinically expressed DDIs was 19.0 %, or 12/63 “certain” ADR cases. Of these, 10 cases presented serious DDI-related ADRs. In summary, ADR causality assessment based exclusively on Naranjo algorithm demonstrated low sensitivity at an ambulatory emergency setting. Additional clinical judgment, including the opinion of the treating physician, proved necessary to avoid under-rating of the causality relationship, and enabled the determination of clinically expressed DDIs.
Rosavin exerts an antitumor role and inactivates the MAPK/ERK pathway in small-cell lung carcinoma in vitro
Authors: Liu Rui , Jiang Cuihong , Zhao Zhizheng , Lv Yutong , Wang Gaoxing 
Published: June 2023

Abstract
This study attempts to explore the function and mechanism of action of rosavin in small-cell lung cancer (SCLC) in vitro. The viability and clone formation of SCLC cells were assessed using cell counting kit-8 and colony formation assays, respectively. Apoptosis and cell cycle were detected using flow cytometry and cell cycle analysis, respectively. Wound healing and transwell assays were performed to evaluate the migration and invasion of SCLC cells. Besides, protein levels of p-ERK, ERK, p-MEK and MEK were determined using Western blot analysis. Rosavin repressed the viability and clone formation of SCLC cells, and promoted apoptosis and G0/G1 arrest of SCLC cells. At the same time, rosavin suppressed migration and invasion of SCLC cells. Moreover, protein levels of p-ERK/ERK and p-MEK/MEK were decreased after rosavin addition in SCLC cells. Rosavin impaired malignant behaviors of SCLC cells, which may be associated with inhibition of the MAPK/ERK pathway in vitro.
Medicarpin induces G1 arrest and mitochondria-mediated intrinsic apoptotic pathway in bladder cancer cells
Authors: Chen Yuan , Yin Liqi , Hao Mingxuan , Xu Wenkai , Gao Jixian , Sun Yuxin , Wang Qiao , Chen Shi , Liang Youfeng , Guo Rui , Zhang Jinku , Li Jinmei , Zhai Qiongli , Cheng Runfen , Wang Jiansong , Wang Haifeng , Yang Zhao 
Published: June 2023

Abstract
Bladder cancer (BC) is the tenth most commonly diagnosed cancer. High recurrence, chemoresistance, and low response rate hinder the effective treatment of BC. Hence, a novel therapeutic strategy in the clinical management of BC is urgently needed. Medicarpin (MED), an isoflavone from Dalbergia odorifera, can promote bone mass gain and kill tumor cells, but its anti-BC effect remains obscure. This study reve aled that MED effectively inhibited the proliferation and arrested the cell cycle at the G1 phase of BC cell lines T24 and EJ-1 in vitro. In addition, MED could significantly suppress the tumor growth of BC cells in vivo. Mechanically, MED induced cell apoptosis by upregulating pro-apoptotic proteins BAK1, Bcl2-L-11, and caspase-3. Our data suggest that MED suppresses BC cell growth in vitro and in vivo via regulating mitochondria-mediated intrinsic apoptotic pathways, which can serve as a promising candidate for BC therapy.
Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences
Authors: Muriel Javier , Escorial Mónica , Margarit César , Barrachina Jordi , Carvajal Cristian , Morales Domingo , Peiró Ana M. 
Published: June 2023

Abstract
More than half of patients with opioid use disorder for chronic non-cancer pain (CNCP) reduced their dose through a progressive opioid withdrawal supported by a rotation to buprenorphine and/or tramadol. The aim of this research is to analyse the long-term effectiveness of opioid deprescription taking into account the impact of sex and pharmacogenetics on the inter-individual variability. A cross-sectional study was carried out from October 2019 to June 2020 on CNCP patients who had previously undergone an opioid deprescription (n = 119 patients). Demographic, clinical (pain, relief and adverse events) and therapeutic (analgesic use) outcomes were collected. Effectiveness (< 50 mg per day of morphine equivalent daily dose without any aberrant opioid use behaviour) and safety (number of side-effects) were analysed in relation to sex differences and pharmacogenetic markers impact [OPRM1 genotype (rs1799971) and CYP2D6 phenotypes]. Long-term opioid deprescription was achieved in 49 % of the patients with an increase in pain relief and a reduction of adverse events. CYP2D6 poor metabolizers showed the lowest long-term opioid doses. Here, women showed a higher degree of opioid deprescription, but increased use of tramadol and neuromodulators, as well as an increased number of adverse events. Long-term deprescription was successful in half of the cases. Understanding sex and gender interaction plus a genetic impact could help to design more individualized strategies for opioid deprescription.
Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development
Authors: Baranasic Jurica , Niazi Yasmeen , Chattopadhyay Subhayan , Rumora Lada , Ćorak Lorna , Dugac Andrea Vukić , Jakopović Marko , Samaržija Miroslav , Försti Asta , Knežević Jelena 
Published: June 2023

Abstract
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are closely related diseases associated with smoking history and dysregulated immune response. However, not all smokers develop the disease, indicating that genetic susceptibility could be important. Therefore, the aim of this study was to search for the potential overlapping genetic biomarkers, with a focus on single nucleotide polymorphisms (SNPs) located in the regulatory regions of immune-related genes. Additionally, the aim was to see if an identified SNP has potentially an effect on proinflamma-tory cytokine concentration in the serum of COPD patients. We extracted summary data of variants in 1511 immune-related genes from COPD and LC genome-wide association studies (GWAS) from the UK Biobank. The LC data had 203 cases, patients diagnosed with LC, and 360 938 controls, while COPD data had 1 897 cases and 359 297 controls. Assuming 1 association/gene, SNPs with a p-value < 3.3 × 10–5 were considered statistically significantly associated with the disease. We identified seven SNPs located in different genes (BAG6, BTNL2, TNF, HCP5, MICB, NCR3, ABCF1, TCF7L1) to be associated with the COPD risk and two with the LC risk (HLA-C, HLA-B), with statistical significance. We also identified two SNPs located in the IL2RA gene associated with LC (rs2386841; p = 1.86 × 10−4) and COPD (rs11256442; p = 9.79 × 10−3) but with lower significance. Functional studies conducted on COPD patients showed that RNA expression of IL2RA, IFNγ and related proinflammatory cytokines in blood serum did not correlate with a specific genotype. Although results presented in this study do not fully support our hypothesis, it is worth to mention that the identified genes/SNPs that were associated with either COPD or LC risk, all were involved in the activation of the NF-κB transcription factor which is closely related to the regulation of the inflammatory response, a condition associated with both pathologies.
The Role of Music Education in Childhood
Authors: Szűcs Tímea , Juhász Erika 
Published: June 2023

Abstract

Introduction:
From the second half of the 20th century onwards, studies on the transfer effects of music learning have become increasingly common. Both in the domestic and international literature, we can read research with a solid scientific background that supports the transfer effects of music education on different aspects of life.

Purpose:
The aim of paper was to map the effect of learning music in childhood based on both the international and the Hungarian scientific literature.

Methods:
When analyzing the social impact of learning music in detail we distinguished five areas: 1. state of physical development, skillfulness, health; 2. cognitive skills; 3. personal development and emotional intelligence; 4. the role of compensating for deficit; 5. community building. In this study we present in detail the results of research studies in these fields.

Conclusions:
In our opinion music education institutions transmit several values and hidden curriculum to children the effect of which serves as a determining and formative factor throughout their whole lives. That is why it is important that, based on the research findings, teachers should be aware of it and consciously control it. In our view learning music can act as a supporting factor for the physical, spiritual and mental development of the children and apart from improving different areas of competence it can also influence their attitude to work.
Model for Reinvestment Policy in Risk-Free Assets with Various Maturities
Authors: Stoilov T. , Stoilova K. , Kanev D. 
Published: June 2023

Abstract
Logistic tasks are aimed at the optimal distribution of material, energy, financial and human resources. This research has a narrow field aimed at optimal management of financial resources and their redistribution. Specifically, a reinvestment policy model is derived by maximizing the profit of a business entity. Reinvestment is done with risk-free assets, but they have different maturity periods. This makes it difficult to assess the optimal investment strategy, as reinvestment can be done at the end of the maturity period. This study develops a model for a dynamic control process, which leads to the formalization of a discrete integer time optimization problem. Its solution gives a sequence of investments and a total optimal return. The solution to the problem is illustrated in an EXCEL environment. The added value of this study stems from the formalization and quantification of the model for the reinvestment strategy in the optimization problem.
Cryptocurrency Price Prediction Using Enhanced PSO with Extreme Gradient Boosting Algorithm
Authors: Srivastava Vibha , Dwivedi Vijay Kumar , Singh Ashutosh Kumar 
Published: June 2023

Abstract
Due to the highly volatile tendency of Bitcoin, there is a necessity for a better price prediction model. Only a few researchers have focused on the feasibility to apply various modelling approaches. These approaches may prone to have low convergence issues in outcomes and acquire high computation time. Hence a model is put forward based on machine learning techniques using regression algorithm and Particle Swarm Optimization with XGBoost algorithm, for more precise prediction outcomes of three cryptocurrencies; Bitcoin, Dogecoin, and Ethereum. The approach uses time series that consists of daily price information of cryptocurrencies. In this paper, the XGBoost algorithm is incorporated with an enhanced PSO method to tune the optimal hyper-parameters to yield out better prediction output rate. The comparative assessment delineated that the proposed method shows less root mean squared error, mean absolute error and mean squared error values. In this aspect, the proposed model stands predominant in showing high efficiency of prediction rate.
Research on the Knittability of Metallic Yarns in the Warp-knitted Mesh of a Deployable Antenna
Authors: Haiyan Xu , Nanliang Chen , Jinhua Jiang 
Published: June 2023

Abstract
Metallic yarns are difficult to be knitted. To resolve the problem, the paper used the knitted yarn strength utilization factor to quantitatively characterize knittability, which was the ratio of yarn strength after being knitted to that of the original yarns. Furthermore, the relationship between the yarns' basic mechanical properties and the knitted yarn strength utilization factor was investigated by testing the yarns' basic mechanical properties. The results showed that it was feasible to quantitatively characterize the yarns' knittability using the knitted yarn strength utilization factor. And also the breaking strength of yarn was not correlated with the knittability. The elongation at break of the yarn was positively correlated with knittability. The bending stiffness of the yarn was negatively correlated with the knittability. Finally, a multiple linear regression model of the knittability and the mechanical properties of the yarn was developed. The model showed that there was a significant linear relationship between knittability and the elongation of yarns at break and the bending rigidity of yarns, with the bending stiffness of yarns being more significant.
Structural, morphological, and optical properties of AgxO thin films deposited via obliquely angle deposition
Authors: Soltane H. Ben , Akkari F. Chaffar , Gallas B. , Kanzari M. 
Published: June 2023

Abstract
This work reports on the optical, structural, and morphological properties of silver oxide thin films obtained by postoxidation of silver deposited previously by the thermal evaporation technique. The samples were deposited on glass substrates using the oblique angle deposition technique for different angles of incidence γ (γ=0°, 20°, 40°, 60°, 75°, and 85°). γ is defined as the angle between the particle flux and the normal to the substrate. The resulting thin films were annealed in the free air at two temperatures (300°C and 400°C). X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-visible-NIR spectrophotometer were performed to study the crystal structure, as well as the morphological and optical properties (transmittance and reflectance), of the AgxO samples. X-ray diffraction analysis revealed the presence of the AgxO phase for the silver films deposited at a high angle of incidence and for the annealing temperature 300°C. In contrast, the diffractograms of the silver films annealed at 400°C show an amorphous behavior. Optical results indicated that the direct band gap energy increases pursuant to increasing the angle of incidence γ. The absorption coefficients of AgxO thin films were found to be in the range of 103–105 cm−1. Additionally, we determined the birefringence for the layers annealed at 400°C and found that the highest value of birefringence is obtained corresponding to the angle of incidence 60°. Morphological analysis indicated that the porosity increases with the angle of incidence and highlights the amorphous nature of the films, which is attributed to the columnar structure.
Evaluation of Interprofessional Quality Improvement Interventions Led by an Ambulatory Care Pharmacist on Adherence to a Controlled Substance Agreement Policy
Authors: Mohammad Insaf , Alsomairy Sarah , Mawari Mona , Elabdallah Mohamad , Elteriefi Ruaa , George Julie 
Published: June 2023

Background: A controlled substance agreement (CSA) is a risk mitigation strategy for patients managed on controlled substance medications such as opioids and benzodiazepines. Limited literature exists to describe the role of the clinic pharmacy team to promote adherence to CSA monitoring parameters.
Objective: The objective of this study is to evaluate the impact of interprofessional educational and clinical interventions led by an ambulatory care pharmacist on adherence to monitoring parameters within a CSA policy.
Methods: This retrospective observational study included patients on long-term controlled substances who had a clinic visit every 3 months during the study period. The primary outcomes were the proportion of patients with a signed CSA in the electronic medical record (EMR), urine drug screen (UDS) completion, and documentation of review of the statewide prescription drug monitoring program (PDMP) in the EMR 8 months prior to as compared to 8 months after implementation of pharmacist interventions. Results: Among 79 patients (mean age 55.7 years, 65.8% female, 54.4% African American), 8.9% pre- vs 88.6% post-interventions had a signed CSA (p<0.001), 35.4% pre- vs 65.8% post-interventions had a UDS completed (p<0.001), and 32.9% pre- vs 57% post-interventions had documentation of PDMP review (p=0.002).
Conclusion: Adherence to monitoring parameters within a CSA policy significantly improved after educational and clinical interventions led by an ambulatory care pharmacist.
" The Justice and Development Party and the Challenge of Transitioning to a Presidential System in Turkey: A Vision for Political Analysis and Confronting Challenges
Authors: Ahmed Adnan Kazim  , Jassim Mohammed Ahmed  
Published: June 2023

The Turkish governments had witnessed dramatic changes during several decades ,So the article researched in realistic situations to estimate the contemporary events according to what happened now a days .Therefore , many challenges must be tackled in order to assessment the political scene specially after several military intervention in political life ,So these developments required making of amendments in constitutional law to change the political system toward presidential order instead of parliamentary system , and this was happened in constitutional amendments which hold in sixteenth of April 2017 as a result of it .Turkish policies were stable politically and lawfully according to practicing democracy ,and it could be easily to know the nature of political participation as followed constitutionally .So the potentially strongest forces are being enabled to renew the political elites ,and the economic miracle would redistribution of roles among active actors in political life .Erdoğan's supporters point out since the attempted coup which happened in amid of July 2016 ,So the governing party and its government tried to reconstruction of trust between the peoples and political elites mutually , in order to override all challenges and to stabilize the process of democracy.
Expanding Borders in Kurdistan Region: Local and Regional Perspectives
Authors: Harith Qahtan Abd Allah  , Abbas Fadel Atwan  
Published: June 2023

The expansion of borders in the Kurdistan Region has been a contentious issue, with significant implications at both the local and regional levels. The Kurdish Regional Government's attempt to incorporate additional territories, particularly those previously liberated from ISIS, has sparked debates and garnered diverse perspectives.
At the local level, proponents of expanding borders argue that these territories are of historical and cultural significance to the Kurdish people. They view the boundaries as a non-negotiable part of their identity and emphasize the sacrifices made to reclaim them from ISIS. This perspective asserts that incorporating these areas into the Kurdistan Region is crucial for safeguarding Kurdish interests and ensuring their political and economic autonomy.
However, there are also voices of dissent within the local population. Critics express concerns about the potential consequences of expanding borders, including demographic shifts, strained resources, and political instability. Some fear that such a move could exacerbate ethnic tensions and lead to conflicts with non-Kurdish communities residing in these areas.
Regionally, the perspectives on the expansion of Kurdistan's borders vary. Neighboring countries, such as Turkey, Iran, and Syria, have expressed strong opposition to the idea. They fear that it could embolden Kurdish separatist movements within their own territories and destabilize the region. These countries have also raised concerns about potential implications for their own national security and territorial integrity.
On the other hand, there are regional actors who are more supportive or adopt a more nuanced stance. Some argue for diplomatic engagement and negotiation to address the Kurdish aspirations within the framework of existing borders. They emphasize the need for peaceful dialogue and respect for international law to prevent further escalations and find mutually agreeable solutions.
Iraq and the New Middle East Project :Israeli Vision
Authors: Khatab Nadhira Mahmoud 
Published: June 2023

Iraq and New middle East project: Israeli vision ,The topic area of that’s research dealing with Great Middle East project, that’s project which associated with Israeli project and its vision for the region, the importance of that’s plans concerning with Arabic –Israeli conflict and Israeli plans for Iraq after 2003, the premise of that’s paper based upon essential theme, that’s theme its similarities between American project and Israeli one, by objectives and means, that’s make the successful of that’s plans are highly expected.
The research argued the causes of occupation of Iraq and possibility to make Iraq leadership more cooperative with American and Israeli projects.
British Foreign Policy towards the Palestinian Issue Since 2003
Authors: Mustafa Ibrahim Salman Al-Shammari  , Dhari Sarhan Hamadi Al-Hamadani  
Published: June 2023

The topic area of that’s paper dealing with role of Britain in established of Israel, so the paper argued the historical developments of Palestinian question and Role of Britain Government toward peace process since 1992, and then its insight toward plan of Palestinian State.
That’s paper also argued the British Policy toward Israeli violations toward Palestinians people, and increased with settlement policy by many procedures like demolition of houses, or lands confiscation, the researcher argued the Britain position toward that’s violations beside the political developments which happens in Britain after Theresa May took over the power in Ten Downing Street.