bluuebunny/crossref_metadata_2025_split huggingface dataset:
The complete mitogenome of Sarcophaga argyrostoma (Diptera: Sarcophagidae) and phylogenetic analysis of Liopygia
Authors: Feng Yakai , Ren Lipin , Wang Shiwen , Jia Kaile , Wang Feng , Jiang Hai , Huang Jingjing , Guo Yadong 
Published: September 2023

Abstract
Sarcophaga argyrostoma (Robineau-Desvoidy, 1830) is considered to be of great medical, forensic, and ecological importance. However, complete mitogenome information for this species is still scarce. Here, the first complete sequencing of the mitogenome of S. argyrostoma was sequenced and analyzed. The mitogenome of S. argyrostoma was 16,454 bp in size with an AT content of 75.7 %. The gene order and direction among species within the Liopygia subgenus were highly conserved, and no gene rearrangement was found in S. argyrostoma. Selection pressure analysis revealed that all the PCG genes evolved under strong purifying selection. Phylogenetic analysis indicated that S. argyrostoma was closely related to S. ruficornis. The results obtained in this study not only enrich the existing molecular databases of this group but also provide valuable information for subsequent species identification and phylogenetic analysis.
Osteosarcoma Tumor Detection using Different Transfer Learning Models
Authors: Meem Raisa Fairooz , Hasan Khandaker Tabin 
Published: September 2023

Abstract
The clinical image analysis field has increasingly embraced the utilization of transfer learning models due to their reduced computational complexity and improved accuracy, among other benefits. These models, which are pre-trained and do not require training from scratch, eliminate the need for extensive datasets. While transfer learning models are primarily employed for brain, breast, or lung image analysis, other areas such as bone marrow cell detection or bone cancer detection can also derive advantages from their use, particularly considering the limited availability of large datasets for these specific tasks. This research paper investigates the performance of various transfer learning models for the detection of osteosarcoma tumours, a form of bone cancer predominantly found in the long bones of the body's cells. The dataset comprises histopathology images stained with H\&E, categorized into four groups: Viable Tumor, Non-viable Tumor, Non-Tumor, and Viable Non-viable. The datasets were randomly split into training and test sets, following an 80-20 ratio, with 80% used for training and 20% for testing. Four models were evaluated for comparison: EfficientNetB7, InceptionResNetV2, NasNetLarge, and ResNet50. All these models were pre-trained on ImageNet. According to the results, InceptionResNetV2 achieved the highest accuracy (93.29%), followed by NasNetLarge (90.91%), ResNet50 (89.83%), and EfficientNetB7 (62.77%). InceptionResNetV2 also exhibited the highest precision (0.8658) and recall (0.8658) values among the four models.
Assessment of Dietary Patterns in Celiac Disease Patients Using Factor Analysis Method and Its Relationship with Dietary Intake and Anthropometric Measurements
Authors: Morvaridi Mehrnaz , Sadeghi Narges , Alavinejad Pezhman , Sadeghian Mehdi , Tahvilian Negin , Behbahani Hossein Bavi , Ebrahimi Sara , Farsi Farnaz 
Published: September 2023

Abstract
Background/Objectives: Celiac disease (CD) is a systemic and autoimmune enteropathy of the gastrointestinal tract with malabsorption characteristics. The only effective treatment for CD is to strict adherence a gluten-free diet (GFD) throughout life. the objective of this study was evaluated the dietary patterns in celiac disease patients and its relationship with dietary intake and anthropometric measurements in Iran.
Subjects/Methods: This is a case control study on 110 patients with celiac disease who were referred to the Celiac Association of Khuzestan, Iran. Nutritional information was collected using a validated 147-item semi-quantitative food frequency questionnaire (FFQ). The software Stata (StataCorp, Version 14.0) was used to analyze the data. Principal component analysis (PCA) was used to obtain patients' dietary patterns.
Results: There was a significant relationship between age, BMI, and total energy intake with quartiles of healthy dietary pattern score (P < 0.001, P = 0.001, and P = 0.001, respectively). Also, there was a significant relationship between total energy intake with quartiles of unhealthy dietary pattern score and traditional dietary pattern (P < 0.001 and p=0.005 respectively). Moreover, there was a significant association of odd ratio for celiac disease and traditional dietary pattern score.
Conclusions: The main findings of our study revealed that the patients who consumed healthy dietary patterns had lower odds ratio of the celiac disease incidence. Although, the rate of adhere to healthy eating pattern was related to increase BMI and daily calorie intake with rising age of participants.
Neoadjuvant immunochemotherapy for pulmonary large-cell neuroendocrine carcinoma: case report
Authors: Xu Chang , Zhao Guangyin , Zhang Hongyu , Ge Di , Gu Jie 
Published: September 2023

Abstract
Background: Pulmonary large-cell neuroendocrine carcinoma (pLCNEC) represents a rare malignancy characterized by its aggressive behavior and a notably high recurrence rate. Remarkably, there is currently no established standard treatment protocol for this condition.
Case Description: In this report, we present an intriguing case of pLCNEC diagnosed at clinical-stage IIB. This case involves a 64-year-old man with a smoking history spanning four decades. In our approach, we initiated a course of neoadjuvant chemotherapy in combination with pembrolizumab, administered for two cycles prior to surgical resection. This innovative treatment strategy resulted in a significant pathological response, culminating in a major pathological remission (MPR). As of the time of composing this report, the patient has been diligently monitored for 33 months post-surgery, exhibiting no indications of recurrence, and has demonstrated exceptional tolerance to the entire treatment regimen.
Conclusions: We have first reported a clinically successful case of neoadjuvant combination chemotherapy with pembrolizumab in the treatment of pLCNEC. This case offers promising clinical insights and suggests that this therapeutic approach could be a viable option for managing pLCNEC.
Causes and pattern of eye diseases in children attending the paediatric eye unit of Ahmadu Bello University teaching hospital, Shika, Zaria
Authors: Orugun Ayodele Jacob , kabir Oladigbolu kehinde , Pam Victoria H 
Published: September 2023

Abstract
Background
To determine the causes and pattern of eye diseases in children 0-15 years of age attending the Paediatric unit of the Department of Ophthalmology Ahmadu Bello University Teaching Hospital Shika, Zaria with a view of obtaining data for planning of children eye care in the hospital and in similar hospitals around the area.
This was a descriptive cross-sectional study. All children that met the inclusion criteria were recruited. Visual acuity assessments were done in verbal children using Snellen’s chart, Tumbling E-Chart and picture charts while preferential looking, fixation, objection to occlusion were used for preverbal patients. Anterior segment examination was done using a loupe or slit lamp biomicroscope as appropriate while posterior segment was examined by direct ophthalmoscopy. Manual refraction was done using streak retinoscope (cycloplegic refraction when required)
Result:
A total of 12,516 patients attended the Ophthalmology out-patient clinic of the hospital during the 30- month study period (May 2014- Oct. 2016); 1,760 (14.1%) were patients 0- 15 years of age (study population).A total of 448 children were recruited for the study. The male to female ratio M: F was 1.3:1. Allergic conjunctivitis 181 (40.4%), refractive error 42 (9.4%) and infective conjunctivitis 39 (8.7%) were the most common ocular disorders seen. The prevalence of visual impairment was 34.4%.Trauma was the most common cause of uniocular visual impairment. The proportion of blind eyes was 3.1% (n=12)
Conclusions:
The common ocular disorders seen among the children were treatable causes of visual impairment. Public health education is necessary to create awareness on the causes of blindness. However, there was no statistically significant difference in the ocular disorders with respect to age and gender of the children.
ICP-MS-based quantitative analysis of multi-elements in commonly edible products using different microwave-assisted acid extraction (MW-AAE) methods
Authors: POTHURAJU NARESH , P Harish Kumar , Jagdale Rushikant , V Udaya Kumar , Gajbhiye Rahul L. , Parihar Vipan K , V Ravichandiran , P Ramalingam 
Published: September 2023

Abstract
This study quantified 13 hazardous heavy metals in 24 edible products, sourced from Bihar, Uttar Pradesh, and West Bengal regions of India. An inductively coupled plasma-mass spectrometry (ICP-MS) was used for determining the 13 elements of ICH3D document including Class 1 (Arsenic, Cadmium, Lead), Class 2A (Cobalt, Vanadium, Nickle), Class 2B (Thallium, Palladium, Selenium, Silver), and Class 3 (Barium, Copper, Chromium). The certified reference material of 29-Analyte /IMS-102 peach leaves was used for validating the digestion procedure. The elements were extracted from food products using different microwave assisted acid extraction (MW-AAE) procedures viz. method A, B, and C under closed conditions. The ICP-MS conditions demonstrated more sensitive detection for cd (0.009 ppb), Co (0.0098 ppb), Ti (0.0049 ppb) and Ag (0.0006 ppb) and recorded more than 50 ppt (0.05 ppb) for As, Pb, Ni, V, Se and Ba with acceptable BEC levels in the linearity range of 0.1 to 2000 ppb (r2 > 0.9). The precision % RSD and the % recovery (IS: Y, Tb, Sc) for all food products was acceptable. Among the digestion methods, the method A demonstrated more superior detection to Cd, V, Ag, Cu, Ba and Cr, whilst method B detected Thallium. Both methods B and C were equally detected As and Pd. All digestions afforded Pb, Co, Ni, Th and Cu at precise levels. Amongst the elements, Hg, V, Ni, Pd, TI, Pt, and Sb were below the permissible limits whilst As, Pb, Cd, Se, Cr, Cu, Co, Ba, Mo and Ag, were above the limits. The principal component analysis for comparison of digestion procedures revealed that the method-A digestion afforded better extraction for sensitive detection, nevertheless correlation was significant for elements detection from methods A, B, and C.
Endometrioid Carcinoma of the Ovarian Resembling Wolffian Tumor: a case report
Authors: Wang Juan , Hao Xue , Wang Yuan , Zhao Linyuan , Li Yuehong , Wu Wenxin , Zhang Xianghong , Cui Jinfeng 
Published: September 2023

Abstract
Background Endometrioid carcinoma is a common epithelial malignant tumor in the female reproductive system. It mainly occurs in the uterus, fallopian tubes, and ovaries. Endometrioid carcinoma reassembling Wolffian tumor, similar to Wolffian tumor, is a type of endometrial carcinoma with a very rare histological structure. At present, only 23 cases have been reported in domestic and foreign literature, of which 2 cases occurred in the ovary and 21 cases occurred in the fallopian tube lumen. Here, we report a case of endometrioid carcinoma of the ovarian resembling FATWO and review the literature.
Case presentation A 65-year-old female patient presented with dysuria for one month. CT showed a pelvic mass. Macroscopically, the tumors form a solid mass with a gray-red to tan. Microscopically, the tumor was composed of tubular, balk and solid structures, among which many small crowded glands. The small and round tubular structure was composed of simple cuboidal epithelium, and eosinophilic secretions can be seen in the lumen. Immunohistochemical staining showed that CK-Pan, EMA, ER, PR, CK8/18 and CEA were positive in the tumor cells, but WT-1, PAX-8, TTF-1, GATA3, calretinin and α-inhibin negtive, wild-type P53, Ki67 index was 10%. The final diagnosis was endometrioid carcinoma of the ovary resembling Wolffian tumor. The patient was followed up for 1 year and 9 months without recurrence.
Conclusions We review the previously published cases of endometrioid carcinomas of the resembling FATWO, and discuss the principal differential diagnosis of the tumor in the ovary.
Assessment of Transportation Networks Using Multi- Criteria Analysis Methods: Case Study of Transportation Infrastructure Axes of Mongolia
Authors: Urantamir G. , Altanbagana M. , Battsengel V. , Saruul G. , Bayarjargal M. , Tseyenkhand P. 
Published: September 2023

Abstract
Due to globalization and widening regional cooperation, needs of social and economic development, and scientific and technological development, it is necessary to adapt the planning of the transportation infrastructure axes not only with the internal situation, but also with regional economic integration, trade, transit and neighboring countries’ main trunk lines and the transportation infrastructure. The purpose of this study is to determine the vertical and horizontal axes that are located optimally at the regional level, have good geographical conditions for roads, connect major economic regions and centers where goods, industry and population are concentrated, and have a transportation and logistics networks using the potential assessment. The axes and corridors of the transportation infrastructure approved by the Parlament of Mongolia and proposed by academic researchers and international organizations were considered as research objects. In the potential scenarios, a multi-criteria analysis method was used to evaluate the potential using 19 indicators of 9 groups. As a result of the assessment, 4 vertical and 1 horizontal axes were identified to support the social and economic development of Mongolia. The vertical axes of this transportation infrastructure are important for intensifying the development of interstate trade and transport, supporting national and regional social and economic development, and creating economic growth. However, the horizontal axes of the transportation infrastructure is important for connecting the vertical axes, territorial integrity, and creating appropriate conditions for population localization and settlement.
Real-world efficacy and safety of Rituximab, Lenalidomide and İbrutinib combination in patients with Relapsed and/or Refractory Non-Hodgkin Lymphoma
Authors: Koyun Derya , Şahin Uğur , Gökmen Ayla , Özcan Muhit 
Published: September 2023

Abstract

Background
Relapsed or refractory (R/R) Non-Hodgkin Lymphoma (NHL) is associated with poor outcomes and the therapic options are limited. Recently, rituximab, lenalidomide, and ibrutinib (RLI) suggest promising efficacy in some clinical studies. Consequently, we evaluated the RLI in a real-life setting.
Methods
This retrospective, single-center study analyzed the outcomes of RLI as an off label salvage theraphy in patients with R/R NHL from June 2020-April 2022.
Results
We analyzed twenty-one patients including diffuse large B-cell lymphoma (DLBCL) (n = 16), primary central nervous system lymphoma (PCNSL) (n = 2), mantle cell lymphoma (MCL) (n = 2), marginal zone lymphoma (MZL) (n = 1). The most common adverse events (AEs) were fatigue (48%), neutropenia (48%), infection (33%). The median TTR (time to response) was 2 months (range, 1.7–3.8). The ORR (overall response rate) was 38% (95% CI 15%-61%) with 29% CR (complete response) and 9% PR (partial response). The median DoR (duration of response) was 12.8 months (range, 4.4–19.5+). The median OS (overall survival) was 7.9 months (95% CI 2.2–13.5) and median PFS (progression free survival) was 3.5 months (95% CI 0.0-8.3).
Conclusions
Our results suggest that RLI is a viable therapeutic option with promising activity and favorable toxicity profile in patients with R/R NHL.
Detection of trace element levels in biological samples of drug abuser: Halani Sindh, Pakistan
Authors: Chang Sajjad Ali , Balouch Aamna , Nahyoon Waheed Ali , Raja Aamir Ali 
Published: September 2023

Abstract
Illicit drug use has become a global issue, posing significant health, socioeconomic, and cultural risks. The study examined essential trace metal selenium, zinc and copper in blood concentrations, serum and scalp hair samples, from male 240 drug-abuse subjects/patients aged 18–45 categorized into three age groups. The study compared 45 healthy subjects of the same age group using an acid-digestion method supported during sample preparation a microwave oven. The technique atomic-absorption spectrophotometry was employed to identify essential and toxic elements, utilizing certified reference materials for accuracy. Drug abusers' Se and Zn concentrations are lower than those of referent subjects, potentially increasing vulnerability to infection due to poor nutritional status or other contaminants.
Delineation of Aquifer Storage Capacity in Response to Regional Groundwater Development
Authors: Alao Joseph Omeiza , Abduwahab Obanero O. , Lawal Hammed Adeniyi , Mary Ekwu Tongha , Yusuf Mumeen Adebayo , Fahad Abubakar , Abdulsalami Momoh-Jimoh 
Published: September 2023

Abstract
Developing aquifers as part of sustainability efforts towards groundwater development is a tactical approach to meeting water demand and management objectives. Delineation of aquifer storage capacity (ASC) and longitudinal conductance (S_L) is a good approach in an attempt to increase water supply. Due to site-specific needs and demands, ASC and S_L play an all-important role in regional groundwater development and sustainability. This study applied Schlumberger and 2D electrical resistivity image (ERI) to determine the regional aquifer thickness in an attempt to assess the strength of ASC and also evaluation of a local S_L that can also be applicable regional scales using fifteen (15) VES points with one orthogonal profile of 2D ERI. The study shows that the layer resistivity values of the regional aquifer range from 39.9 Ωm – 105 Ωm, while the aquifer layer thickness values spread from 15 m – 44 m and the overburden thickness overlays the aquifer unit extends from 5 m to 10 m. The deeper aquifer zones were delineated within the depth of 30 m – 44 m, and the zones are considered to be suitable for groundwater development. The weathered/fractured basemen, which constitute the regional aquifer are delineated. The weathered layer with appreciably low resistivity values with thick aquifer regolith has also been identified as most suitable for borehole siting. The weathered/fractured encountered within thick aquifer regolith indicates a high storage capacity and positive groundwater development. The longitudinal conductance, SL and transverse resistance, RT estimated from aquifer parameters vary between 0.21 Ω-1-0.85 Ω-1 and 1695 Ωm2-3124Ωm2 respectively. The SL values show that that study area falls within moderate (0.20 Ω-1-0.69 Ω-1) and good (0.7 Ω-1-0.49 Ω-1) ASC, which invariably improved the regional aquifer recovery processing.
Relocating rice cultivation domestically is conducive to climate mitigation and land utilization without compromising food security
Authors: Lee Huey-Lin , Pao Shang-Hung , Lin Chiao-Wen , Lin Wei‐Jen , Chang En-Tse , Chen Wei-Chung , Lee Li-Hua , Wang Ching-Wen , Lin Hsing-Juh 
Published: September 2023

Abstract
Apart from agronomic advancements and field management, spatial redistribution of rice cultivation areas can be an effective way to cut CH4 emissions. Coupling the linear programming approach with subregional in situ CH4 measurements to reveal heterogeneity in locality and cropping season, we assessed the potential of CH4 mitigation via spatial redistribution of Taiwan’s rice cultivation areas without slashing rice production. Our results showed (1) 1,961 kilotons CO2e, or 18%, can be cut from pre-relocation for the normal crop year 2017, which outperforms peak annual carbon sequestration from accumulated afforestation; and (2) saving 9,518 hectares of rice paddies in selected subregions for growing soybean could significantly raise national self-sufficiency rate in soybean from 2% to 8%. We discuss here the feasibility of spatially relocating rice cultivation in the Taiwanese policy context and implications for Asian rice-growing countries in their pursuit of climate mitigation and food security.
Bioremediation of heavy metal-contaminated environment: developed strategies and potential use of biosurfactants as chelators
Authors: Inès Mnif , Mekki Salwa , Dhouha Ghribi 
Published: September 2023

Abstract
Heavy metal pollution damages the ecosystems and presents a major problem for public health. Thus, an urgent need was developed to decrease the high levels of heavy metals in the soil and aquatic environments. With this aim, numerous physicochemical strategies were developed. However, they are money-consuming, require the use of energy and chemical additives and can release secondary compounds that can pollute and cause great damage to the environment. Then, biological methods based on the investigation of bacteria, fungi and plants along with their derived secondary active metabolites became the best alternatives. Using plant capacities, different phytoremediation strategies were developed such as phytoextraction, phytovolatilization, rhizofiltration and phytostabilization. Regarding bioremediation, bacterial biosorption of heavy metals, biolixiviation and lagooning offer great potential for their environmental cleaning. Additionally, the use of secondary active metabolites, such as biosurfactants, is well-studied. Generally, they are a class of structurally very varied molecules commonly synthesized by many microorganisms with amphiphilic character. Owing to their anionic charge, they have the capacity to sequestrate heavy metals permitting their elimination. Glycolipids and lipopeptides are among the most recognized biosurfactants with interesting heavy metal chelating properties.
Anthropomorphizing Nature as a Tool for Environmental Education. Opinions of Pedagogy Students in the Context of Represented Environmental Ethics
Authors: Kozłowska Agnieszka , Czapla Małgorzata 
Published: September 2023

The purpose of the study was to check pedagogy students’ opinions on using anthropomorphizing nature for the development of pro-environmental knowledge and behaviour in the context of their own environmental ethics orientations. An online survey for university pedagogy students from Poznan, Poland, was conducted. N=221 respondents, of whom 97% were women, filled out the questionnaires. Descriptive statistics were used for closed questions on students’ opinions about using anthropomorphizing nature for environmental education. To find out the respondents’ environmental ethics orientations, content analysis of answers to open questions was used, applying theory-based categories of environmental orientations derived from environmental ethics (anthropocentrism, biocentrism). The findings revealed that the majority of students believe that anthropomorphism of nature helps in the development of pro-environmental behaviour (62.4%) and knowledge (55.8%). In justification, most (63.8%) presented anthropocentric attitudes; 27.5% of answers were biocentric, and 8.8% - mixed eclectic. According to the other questions the respondents supported biocentric environmental norms. Their justifications, however, again revealed mostly anthropocentric motivations 63.2%. Conclusion: Pedagogy students, although they support biocentric norms, believe that anthropomorphism of nature will be the right tool for environmental education, and use anthropocentric arguments in their justifications. In their future pedagogical practice, they will rather develop anthropocentric orientations in children, building positive attitudes towards nature on (false) belief in similarities of human and non-human living organisms, instead of recognition of their “otherness” and intrinsic value.