bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of effective coverage for type 2 diabetes in Mexican primary care health information systems: a retrospective registry analysis
Authors: Gallardo-Rincón Héctor , Ríos-Blancas María Jesús , Montoya Alejandra , Saucedo-Martínez Rodrigo , Morales-Juárez Linda , Mujica Ricardo , Cantoral Alejandra , Idueta Lorena Suarez , Lozano Rafael , Tapia-Conyer Roberto 
Published: April 2023

Abstract
Background
As the leading cause of disability and the fourth leading cause of premature death in Mexico, type 2 diabetes (T2D) represents a serious public health concern. The incidence of diabetes has increased dramatically in recent years, and data from the Mexican National Health and Nutrition Survey (ENSANUT) indicate that many people remain undiagnosed. Persistent socioeconomic health care barriers exacerbate this situation, as T2D morbidity and mortality are worsened in vulnerable populations, such as those without social security. We evaluated the performance of public primary health centers (PHCs) in T2D medical attention through the measure of effective coverage (EC, a combined measure of health care need, use, and quality) at national, state, health jurisdiction, and municipality levels.

Methods
This retrospective analysis used blinded data recorded during 2017 in the Non-communicable Diseases National Information System (SIC) and T2D prevalence reported in 2018 ENSANUT to evaluate the EC achieved. We included individuals ≥ 20 years old without social security who did not declare the use of private health care services. Each EC component (need, use, and quality) was estimated based on the Shengelia adapted framework. The Kruskal–Wallis test was applied to evaluate the associations among EC quintiles and demographics.

Results
In 2017, 26.5 million individuals, aged ≥ 20 years, without social security, and without the use of private health care services, were under the care of 12,086 PHCs. The national prevalence of T2D was 10.3%, equivalent to 2.6 million people living with T2D in need of primary health care. Large contrasts were seen among EC components between and within Mexican states. We found that only 37.1% of the above individuals received health services at PHCs and of them, 25.8% improved their metabolic condition. The national EC was 9.3%, and the range (by health jurisdiction) was 0.2%–38.6%, representing a large geographic disparity in EC. We found an evident disconnect among need, utilization, and quality rates across the country.

Conclusions
Expansion and improvement of EC are urgently needed to address the growing number of people living with T2D in Mexico, particularly in states with vulnerable populations.
High prevalence of olfactory impairment among leprosy patients: A cross-sectional study
Authors: Kondo Rogério Nabor , Araújo Milene Cripa Pizatto de , Ramos Paulo Muller , Miot Hélio Amante , Fornazieri Marco Aurélio 
Published: April 2023

Background
The effect of leprosy on the sense of smell is not yet fully established. Studies that have relied only on patients’ perceptions may have under- or over-estimated the change in smell perception. A validated and psychophysical method is necessary to avoid these errors in assessment.

Objectives
This study aimed to validate the existence of olfactory involvement in leprosy patients.

Methods
A cross-sectional, controlled study was conducted, in which individuals with leprosy (exposed individuals) and individuals without leprosy (control patients) were recruited. For each exposed individual, we selected two control patients. A total of 108 patients (72 control patients and 36 exposed individuals) with no history of infection with the new coronavirus (COVID-19) took the University of Pennsylvania Smell Identification Test (UPSIT).

Results
Most exposed individuals had olfactory dysfunction [n = 33, 91.7% (CI 95%: 77.5%–98.3%)] when compared with the control patients [n = 28, 38.9% (CI 95%: 27.6%-51.1%)], but only two (5.6%) had olfactory complaints. The olfactory function was significantly worse among exposed individuals [UPSIT leprosy = 25.2 (CI 95%: 23.1–27.3) when compared with the UPSIT control patients = 34.1 (CI 95%: 33.0–35.3); p<0.001]. The risk of olfactory loss was higher among the exposed individuals [OR: 19.5 (CI 95%: 5.18–105.70; p < 0.001)].

Conclusions
Olfactory dysfunction was highly prevalent among exposed individuals, although they had little or no self-knowledge of the disorder. The results show that it is important to assess the sense of smell in exposed individuals.
3D-PDNet: Automated Product Disassembly Sequence Planning
Authors: Upadhyay Abhinav , Ladrecha Bharat , Dubey Alpana , Kuriakose Suma Mani , Goenka Piyush 
Published: April 2023

Abstract
Product Disassembly has become an area of active research as it sup- ports sustainable development by aiding effective end-of-life (EOL) stage strategies like reuse, re-manufacturing, recycling, etc. In this work, we propose a new approach, 3D-PDNet, that can utilize 3D data from CAD assembly models to generate a feasible disassembly sequence. Our approach uses Graph-based learning to process the graph representa- tion of CAD models. Currently, the available 3D CAD model datasets lack ground truth disassembly sequences. We propose and curate a new dataset, the 3D-PD dataset, which includes ground truth information about the disassembly sequence for 3D product models. We carry out evaluation and analysis of results to explain the efficacy of the proposed method. Our approach significantly outperforms the existing baseline. We develop an Autodesk Fusion 360 plug-in that generates disassembly sequence animation, allowing intuitive analysis of the disassembly plan.
Interaction between N6-methyladenosine and autophagy in the immune infiltration and subtype classification of thyroid eye disease
Authors: Zhao Andi , Gong Qi , Chen Xuejuan 
Published: April 2023

Abstract
Background:Thyroid eye disease (TED) is a chronic inflammatory autoimmune disease with a complex etiology. N6-methyladenosine (m6A) modification and autophagy were confirmed separately to be involved in the TED process. Increased evidence has shown that m6A is critical in regulating autophagy in various diseases. However, there is limited knowledge about the interactive effects of m6A modification and autophagy in TED. Our research aimed to investigate the effects of m6A modification and autophagy interactivity in TED.
Results: We first identified dysregulation of five m6A regulators and 44 ARGs in TED patients compared to healthy controls. After correlation analysis, overlapping with the validated target genes from the RM2target database, and verification in our samples, FTO and BNIP3 were considered biomarkers for TED. Subsequently, based on dysregulated m6A regulators and ARGs separately, we classified 27 TED patients into two clusters, and the immune infiltration characteristics of clusters were further evaluated. Cluster-related differentially expressed genes were identified, and the enriched biological functions and pathways were elucidated. In addition, using two machine learning algorithms, we created a prediction model for TED patients with different molecular clusters. The nomogram, calibration curve, and decision curve analysis were performed to assess the performance of the predictive model.
Conclusions: This study revealed that an interactive effect between FTO and BNIP3, suppressed FTO might downregulate the expression of BNIP3 in an m6A-dependent manner, inhibiting the autophagy and subsequently promoting the TED process. In addition, we constructed a nomogram model in predicting the TED. These results provide new insights into understanding the mechanism of TED.
OmniGlasses: An Optical Aid for Stereo Vision CNNs to Enable Omnidirectional Image Processing
Authors: Seuffert Julian Bruno , Grassi Ana Cecilia Perez , Ahmed Hamza , Seidel Roman , Hirtz Gangolf 
Published: April 2023

Abstract

Stereo vision is a key technology for 3D scene reconstruction from image pairs. Most approaches process perspective images from commodity cameras. These images, however, have a very limited field of view and only picture a small portion of the scene. In contrast, omnidirectional images, also known as fisheye images, exhibit a much larger field of view and allow a full 3D scene reconstruction with a small amount of cameras if placed carefully. However, omnidirectional images are strongly distorted which make the 3D reconstruction much more sophisticated. Nowadays, a lot of research is conducted on CNNs for omnidirectional stereo vision. Nevertheless, a significant gap between estimation accuracy and throughput can be observed in the literature. This work aims to bridge this gap by introducing a novel set of transformations, namely OmniGlasses. These are incorporated into the architecture of a fast network, i.e., AnyNet, originally designed for scene reconstruction on perspective images. Our network, Omni-AnyNet, produces accurate omnidirectional distance maps with a mean absolute error of around 13 cm at 36.4 fps and is therefore real-time capable.
Minat Beli Memediasi Pengaruh E-Service Quality Dan Promosi Terhadap Keputusan Pembelian Di Shopee (Studi Kasus Pada Mahasiswa Manajemen Ukrida 2017)
Authors: Tecoalu Melitina , Yonathan Kelvin , Tj Hery Winoto 
Published: April 2023

Technological developments support an increase in online buying and selling activities in marketplaces that have turned conventional transactions into digital ones. The quality of services and promotions offered have also turned digital. The purpose of this study was to examine the effect of e-service quality and promotion on purchasing decisions at Shopee which are mediated by purchase intention. By using a sample of 60 students of the 2017 UKRIDA Management Departement with a purposive sampling technique. The data analysis technique used in this research is Structural Equation Modeling (SEM) using the SmartPLS version 3.0 software. The results obtained in this study indicate that there is an effect of e-service quality on purchasing decisions and purchase intentions, while promotion has no effect on purchasing decisions. Meanwhile, mediation of purchase intention strengthens the influence of e-service quality and promotion on purchasing decisions.
Keywords: e-service quality, promotion, purchasing decisions, purchase intention
Multisystem inflammatory syndrome in children during the first two years of the COVID-19 pandemic in Luxembourg
Authors: Ooms C. , Mossong J. , Vergison A. , Biver A. , Wagner K. , Niel O. , Parrish A. , Abdelrahman T. T. , de la Fuente Garcia I. 
Published: April 2023

ObjectiveEstimate the incidence of multisystem inflammatory syndrome (MIS-C) in children (0–15 years), the role of SARS-CoV-2 variants during the first two years of COVID-19 pandemic in Luxembourg; and describe the demographic, biological and clinical characteristics of the patients.MethodObservational retrospective cohort study. Cases between March 2020 and February 2022 were ascertained from the national registry of MIS-C cases by a retrospective review of medical records. Reported SARS-CoV-2 infections were obtained from the national COVID-19 surveillance system. We calculated monthly MIS-C incidence, the ratio between MIS-C and SARS-CoV-2 infections and associated rate ratios by the periods corresponding to the circulation of different variants.Results18 children were diagnosed with MIS-C among 35,200 reported infections. The incidence rate of MIS-C was 7.2 [95% confidence interval (CI) 4.5–11.4] per 1,000,000 person-months. A higher incidence of MIS-C was observed between September and December 2021, corresponding to the circulation of the Delta variant than during the first year of the pandemic (RR 3.6, 95% CI, 1.1–12.3). The lowest rate of MIS-C per infection was observed during the Omicron (RR 0.17, 95% CI, 0.03–0.82). Median age at diagnosis was 6.5 years. Previously healthy children made up 88% of MIS-C cases, none were vaccinated against SARS-CoV-2. 33% required intensive care. All patients recovered fully.ConclusionsMIS-C incidence and MIS-C risk per infection changed significantly over time during the first two years of COVID-19 pandemic. Monitoring of MIS-C incidence in future SARS-CoV-2 waves will be essential to guide public health interventions and vaccination policies for children.
Deploying automated ticket router across the enterprise
Authors: Ackerman Samuel , Alexander Lincoln , Bennett Margaret , Chen Donglin , Farchi Eitan , Houseknecht Autumn , Santhanam Padmanabhan 
Published: April 2023

AbstractWith the recent advances in machine learning, the use of natural language processing (NLP) technology to support various business processes has been increasing. This paper discusses the use of NLP to route more than one million live client tickets annually to the appropriate service personnel in 67 support missions across IBM. Each mission supports a product family with multiple support teams, each requiring different skills for the engineers. We discuss three important aspects of such a large‐scale deployment: (i) The use of a centralized team with a common machine learning infrastructure and practices to support the entire enterprise. (ii) The processes and quality of such a deployment from the perspective of one support mission, namely, IBM's z/OS family. (iii) Careful monitoring of the deployed models to detect drifts in the routing behavior. Despite vast differences in the technical contents of the support missions, it is possible to define common processes and metrics across the enterprise, without requiring a dedicated machine learning team for each mission. In addition, we provide examples of the business policies and metrics from the perspective of the z/OS mission to demonstrate the utility of the approach and the outcome.
Differential Fractal and Circadian Patterns in Motor Activity in Spontaneously Hypertensive Rats at the Stage of Prehypertension
Authors: Yilmaz Ajda , Li Peng , Kalsbeek Andries , Buijs Ruud M , Hu Kun 
Published: April 2023

AbstractOne possible pathological mechanism underlying hypertension and its related health consequences is dysfunction of the circadian system—a network of coupled circadian clocks that generates and orchestrates rhythms of ≈24 h in behavior and physiology. To better understand the role of circadian function during the development of hypertension, circadian regulation of motor activity is investigated in spontaneously hypertensive rats (SHRs) before the onset of hypertension and in their age‐matched controls—Wistar Kyoto rats (WKYs). Two complementary properties in locomotor activity fluctuations are examined to assessthe multiscale regulatory function of the circadian control network: 1) rhythmicity at ≈24 h and 2) fractal patterns—similar temporal correlation at different time scales (≈0.5–8 h). Compared to WKYs, SHRs have more stable and less fragmented circadian activity rhythms but the changes in the rhythms (e.g., period and amplitude) from constant dark to light conditions are reduced or opposite. SHRs also have altered fractal activity patterns, displaying activity fluctuations with excessive regularity at small timescales that are linked to rigid physiological states. These different rhythmicity/fractal patterns and their different responses to light in SHRs indicate that an altered circadian function may be involved in the development of hypertension.
Secondary Structure in Overcoming Photosensitizers’ Aggregation: α‐Helical Polypeptides for Enhanced Photodynamic Therapy
Authors: Xu Xiang , Ma Jinjuan , Zheng Yubin , Wang Shaolei , Wang Aiguo , Zheng Nan 
Published: April 2023

AbstractAggregation caused quenching (ACQ) effect can severely inhibit the application of hydrophobic photosensitizers (PSs) bearing planar and rigid structures. Most of the reported cases utilized random‐coiled polymers for the in vivo delivery of PSs, which would inevitably aggravate ACQ effect due to the flexible chains. In this work, the role of polymers’ secondary structures (especially α‐helical conformation) in overcoming the PSs’ aggregation is systemically investigated based on the design of α‐helical polypeptides bearing tetraphenylporphyrin (TPP) side chains. Atomistic molecular dynamics simulation, fluorescence quantum yield, and reactive oxygen species (ROS) generation yield are evaluated to demonstrate that α‐helical polypeptide backbones can significantly boost both fluorescence quantum yield and ROS by suppressing the π‐π stacking interaction between TPP units. The enhanced in vitro and in vivo phototoxicity for helical polypeptides also reveal functions of secondary structures in inhibiting ACQ and improving the membrane activity. Successful in vivo photodynamic therapy (PDT) results in mice bearing H22 tumors showed great potentials for further clinical applications.
Bioinspired Drag Reduction of Cavities Induced by Janus Nanostructure Interfaces on Hydrophobic Spheres Plunging into Water with a Low Speed
Authors: Xie Jingjing , Yao Changzhuang , Shi Zhenmin , Wang Jingming , Jiang Lei 
Published: April 2023

AbstractForm drag of the blunt object occurs from the pressure difference due to the physical dimensions of the object obstructing and altering the flow of the fluid. The innovative approach of form drag reduction is realized by changing the shape of the blunt object to a streamlined body by introducing a cavity. The construction of superhydrophobic interfaces is widely considered as the best solution for introducing a cavity, because water is prevented from penetrating the space between the nanoscale structures, leading to a Cassie–Baxter wetting regime and then water splashing outward. Here, by introducing Janus nanostructure coating on hydrophobic spheres, it is found that the position (impacting direction) and coverage ratio (r) of the nanostructures, accurately manipulate the performance of water film on the sphere surface. When the nanostructure faces upward, the detached thin film develops to a splash crown only if r increases to 1/3 or even above. Correspondingly, the remaining open aperture aids in increasing the subsequent air entrainment, and an air‐entrainment cavity is trapped on the sphere surface. However, if the nanostructure faces downward, only a tiny region of the nanostructures (r ≤ 1/8) can help a thin liquid film directly develop into a splash crown and cavity.
Influence of Initial Surface Roughness on LIPSS Formation and Its Consecutive Impact on Cell/Bacteria Attachment for TiAl6V4 Surfaces
Authors: Sotelo Lamborghini , Fontanot Tommaso , Vig Sanjana , Herre Patrick , Yousefi Peyman , Fernandes Maria Helena , Sarau George , Leuchs Gerd , Christiansen Silke 
Published: April 2023

AbstractThe influence of the initial surface roughness of TiAl6V4 samples on the orientation and periodicity of the resulting laser‐induced periodic surface structures (LIPSS), as well as the surface wettability and chemistry is reported here. Before LIPSS fabrication, initial sample surface roughness is adjusted by variations of finial polishing steps with polishing grain sizes of 18.3, 8.4, 5, and 0.5 µm. A 3 × 3 irradiation matrix was defined and lasered on all samples by changing the laser power and distance between consecutive laser scans. The resulting structures were characterized by scanning electron microscopy (SEM), atomic force microscopy, Raman spectroscopy, and contact angle measurements. As a further step, three representative generated structures were chosen to explore their bone implant viability by resazurin assays, alkaline phosphatase activity, and direct SEM imaging of the induced cells (MG63) and bacteria (Escherichia coli and Staphylococcus aureus). Results show that initial surface roughness has big influence on the wettability of the resulting surface, as well as inducing small variations on the orientation of the generated LIPSS. Structures generated with a higher integrated fluence have also shown to enhance cell differentiation while reducing bacterial activity, making them a great candidate for improved bone implant compatibility and durability.
A Machine‐Braided Flame‐Retardant Triboelectric Yarn/Textile for Fireproof Application
Authors: Cui Xiuju , Li An , Zheng Zongni , Wu Hanguang , Wang Rui 
Published: April 2023

AbstractWith the rapid development of the textile‐based triboelectric nanogenerators (T‐TENGs), it is highly desired to create a simple and cheap fabrication strategy for the T‐TENGs with high flame‐retardant performances (FRT‐TENGs), which can present reliable electrical performance in the fire disaster. In this work, by covering the flame‐retardant polyethylene terephthalate filaments around the conductive fiber, a flame‐retardant triboelectric yarn is successfully developed through a simple and continuous high‐speed braiding process. The obtained composite yarns are further woven into an FRT‐TENG, which presents excellent comprehensive performances, including good energy harvesting ability, long‐term durability and washability, excellent flame retardancy, and high comfortability. The open‐circuit voltage (VOC) and short‐circuit current (ISC) can reach nearly 12 V and 0.36 µA, respectively. The FRT‐TENG shows a high limiting oxygen index value of 31.3% and self‐extinguishing behavior, and still presents high energy output performances after the burning, making it a perfect candidate for intelligent devices with high fireproof ability, such as the smart firefighter uniform and the intelligent carpet for escape direction indication.
Aerosol‐Jet Printed Sensors for Environmental, Safety, and Health Monitoring: A Review
Authors: Fisher Christine , Skolrood Lydia N. , Li Kai , Joshi Pooran C. , Aytug Tolga 
Published: April 2023

AbstractAn emergent direct‐write approach, aerosol‐jet printing (AJP), is gaining attention for the deployment of rapid and affordable microadditively manufactured energy‐efficient sensors and printed electronics. AJP enables a broad range of ink viscosities (0.001–1 Pa s) for printing diverse materials ranging from ceramics and metals to polymers and biological matter. Reproducible, high‐spatial‐resolution features (≈10 µm), and wide standoff distances (1–11 mm) between the nozzle and the substrate facilitate conformal printing of complex geometrical designs on nonplanar—e.g., stepped or curved—surfaces. This paper aims to provide a comprehensive overview of state‐of‐the‐art AJP‐based sensors (e.g., strain and temperature gauges, biosensors, photosensors, humidity and surface acoustic wave sensors, dielectric elastomer actuators, and motion, smoke, and hazardous gas detectors) and to discuss prospective applications. The drive toward cost‐effective devices that are smaller, lighter, and better‐performing remains a frontier challenge in the field of printed electronics. Consequently, as AJP becomes increasingly utilized in the high‐volume manufacturing of miniaturized active and passive sensors, it opens a pathway for facile large‐scale fabrication of devices for a wide range of consumer and industrial applications, including transportation, agriculture, infrastructure, aerospace, national defense, and healthcare.