bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feeling comfortable with a mortgage: The impact of framing, financial literacy and advice
Authors: Thorp Susan , Liu Junhao , Agnew Julie , Bateman Hazel , Eckert Christine , Iskhakov Fedor 
Published: April 2023

AbstractThe family home is the most important asset on household balance sheets, aside from human capital. Choosing a suitable mortgage is therefore critical to financial well-being but households often make costly mistakes. We collect data in an online survey to test borrowers’ comfort with, and understanding of, mortgage debt. We analyze the impact of financial literacy, mortgage broker advice and whether the loan is framed as a lump sum debt or an equivalent stream of repayments. We conjecture that participants’ comfort with loans and their ability to match lump sum debt to equivalent repayment streams will help them to choose a suitable mortgage. Results show that participants with high financial literacy are less comfortable with mortgage debt in general and also less sensitive to framing than those with low financial literacy. Literate participants are better able to match repayment streams with the equivalent lump sums. Endogeneity-controlled regression analysis shows that consulting brokers leads to higher comfort with debt and lower sensitivity to framing. Survey responses also indicate more uncertainty about future house prices among borrowers who intend to consult brokers than among those who do not.
THE REVERSE MATHEMATICS OF
${\mathsf {CAC\ FOR\ TREES}}$
Authors: CERVELLE JULIEN , GAUDELIER WILLIAM , PATEY LUDOVIC 
Published: April 2023

Abstract
${\mathsf {CAC\ for\ trees}}$
is the statement asserting that any infinite subtree of
$\mathbb {N}^{<\mathbb {N}}$
has an infinite path or an infinite antichain. In this paper, we study the computational strength of this theorem from a reverse mathematical viewpoint. We prove that
${\mathsf {CAC\ for\ trees}}$
is robust, that is, there exist several characterizations, some of which already appear in the literature, namely, the statement
$\mathsf {SHER}$
introduced by Dorais et al. [8], and the statement
$\mathsf {TAC}+\mathsf {B}\Sigma ^0_2$
where
$\mathsf {TAC}$
is the tree antichain theorem introduced by Conidis [6]. We show that
${\mathsf {CAC\ for\ trees}}$
is computationally very weak, in that it admits probabilistic solutions.
Cerebrospinal fluid neurofilament light predicts longitudinal diagnostic change in patients with psychiatric and neurodegenerative disorders
Authors: Kang Matthew J. Y. , Eratne Dhamidhu , Dobson Hannah , Malpas Charles B. , Keem Michael , Lewis Courtney , Grewal Jasleen , Tsoukra Vivian , Dang Christa , Mocellin Ramon , Kalincik Tomas , Santillo Alexander F. , Zetterberg Henrik , Blennow Kaj , Stehmann Christiane , Varghese Shiji , Li Qiao-Xin , Masters Colin L. , Collins Steven , Berkovic Samuel F. , Evans Andrew , Kelso Wendy , Farrand Sarah , Loi Samantha M. , Walterfang Mark , Velakoulis Dennis 
Published: April 2023

AbstractObjective:People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY), its accuracy in a diagnostically challenging cohort longitudinally is unknown.Methods:We collected longitudinal diagnostic information (mean = 36 months) from patients assessed at a neuropsychiatry service, categorising diagnoses as ND/mild cognitive impairment/other neurological disorders (ND/MCI/other) and PSY. We pre-specified NfL > 582 pg/mL as indicative of ND/MCI/other.Results:Diagnostic category changed from initial to final diagnosis for 23% (49/212) of patients. NfL predicted the final diagnostic category for 92% (22/24) of these and predicted final diagnostic category overall (ND/MCI/other vs. PSY) in 88% (187/212), compared to 77% (163/212) with clinical assessment alone.Conclusions:CSF NfL improved diagnostic accuracy, with potential to have led to earlier, accurate diagnosis in a real-world setting using a pre-specified cut-off, adding weight to translation of NfL into clinical practice.
Design and development of a SLPM-based deployable robot
Authors: Zhang Ze , Zhuang Zheming , Guan Yuntao , Dai Jiansheng 
Published: April 2023

AbstractWith the progress of industry, people are facing more and more complicated tasks, which cannot be completed by conventional rigid robot. For this, a deployable robot based on spherical linkage parallel mechanism was proposed to satisfy relevant requirements for the degrees of freedom in this study. Based on the design of robot model and its control box, a mathematical model for the robot was established, and the relationship between motion space and drive space was deduced accordingly. Subsequently, a control system consisting of the upper and lower computers was introduced. Two control modes, that is, Joystick control and remote control, were developed. The upper computer control interface for the robot was completed by MATLAB construction. At last, the two control modes as well as autonomous detection were demonstrated by motion test. This achievement will further advance the applications of deployable robot in job aid and intelligent exploration.
Oath-taking and the politics of secrecy in medieval and early modern British towns
Authors: Cuenca Esther Liberman 
Published: April 2023

AbstractIn premodern Britain civic officials took oaths in solemn ceremonies in full view of their colleagues and fellow citizens. This article examines oaths ranging from the fourteenth to the seventeenth centuries from 31 towns in England, Scotland, and Ireland to demonstrate how officials were ritually enjoined to keep secrets. Oaths were public acknowledgments that secrets were going to be kept. The act of governing necessitated the keeping of secrets to ensure the protection of the town's interests. But oath-taking was also a concession to the idea that governing required a degree of transparency for the ruling elite and other authorities to appear legitimate and incorruptible.
Fluoroscopy-free, echocardiography-guided hybrid stenting of native aortic coarctation in a 920-grams premature infant
Authors: Tagorti Maha , Benbrik Nadir , Baruteau Alban-Elouen 
Published: April 2023

AbstractTherapeutic options are limited for the management of extremely low-birth-weight infants with critical aortic coarctation despite high doses of prostaglandin infusion. We report successful hybrid, fluoroscopy-free, echocardiography-guided primary stenting of native aortic coarctation in a 920-grams premature infant.
Community participation in the health system: analyzing the implementation of community health committee policies in Kenya
Authors: Karuga Robinson , Dieleman Marjolein , Mbindyo Patrick , Ozano Kim , Wairiuko Judy , Broerse Jacqueline E.W. , Kok Maryse 
Published: April 2023

Abstract

Background:
Community health committees (CHCs) are a mechanism for communities to voluntarily participate in making decisions and providing oversight of the delivery of community health services. For CHCs to succeed, governments need to implement policies that promote community participation. Our research aimed to analyze factors influencing the implementation of CHC-related policies in Kenya.

Methods:
Using a qualitative study design, we extracted data from policy documents and conducted 12 key informant interviews with health workers and health managers in two counties (rural and urban) and the national Ministry of Health. We applied content analysis for both the policy documents and interview transcripts and summarized the factors that influenced the implementation of CHC-related policies.

Findings:
Since the inception of the community health strategy, the roles of CHCs in community participation have been consistently vague. Primary health workers found the policy content related to CHCs challenging to translate into practice. They also had an inadequate understanding of the roles of CHCs, partly because policy content was not adequately disseminated at the primary healthcare level. It emerged that actors involved in organizing and providing community health services did not perceive CHCs as valuable mechanisms for community participation. County governments did not allocate funds to support CHC activities, and policies focused more on incentivizing community health volunteers (CHVs) who, unlike CHCs, provide health services at the household level. CHVs are incorporated in CHCs.

Conclusion:
Kenya’s community health policy inadvertently created role conflict and competition for resources and recognition between community health workers involved in service delivery and those involved in overseeing community health services. Community health policies and related bills need to clearly define the roles of CHCs. County governments can promote the implementation of CHC policies by including CHCs in the agenda during the annual review of performance in the health sector.
A HECKE ACTION ON -MODULES
Authors: Abe Noriyuki 
Published: April 2023

AbstractWe construct an action of the affine Hecke category on the principal block
$\mathrm {Rep}_0(G_1T)$
of
$G_1T$
-modules where G is a connected reductive group over an algebraically closed field of characteristic
$p> 0$
, T a maximal torus of G and
$G_1$
the Frobenius kernel of G. To define it, we define a new category with a Hecke action which is equivalent to the combinatorial category defined by Andersen-Jantzen-Soergel.
Multispacecraft Observations of the Simultaneous Occurrence of Magnetic Reconnection at High and Low Latitudes During the Passage of a Solar Wind Rotational Discontinuity Embedded in the April 9‐11, 2015 ICME
Authors: Wing Simon , Berchem Jean , Escoubet C. Philippe , Farrugia Charles , Lugaz Noé 
Published: April 2023

AbstractNumerous questions remain about how solar wind directional discontinuities, for example, rotational discontinuities (RDs), affect energy and transport processes at the magnetopause. The impact on the dayside magnetosphere of a solar wind RD is studied. The study shows that the RD leads to complex structures at the magnetopause, boundary layer, mantle, and cusp even though the geomagnetic activity level remains low. At low altitudes, the Defense Meteorological Satellite Program spacecraft observe a double cusp that is a signature of magnetic reconnection occurring at both high and low latitudes due to the dominant IMF By, while Cluster C2, located at high‐latitude and high‐altitude in the southern hemisphere, observes velocity fluctuations and reversals with peak‐to‐peak amplitudes >800 km s−1 as it crosses the magnetopause. A global MHD simulation of the event shows that the C2 observations are consistent with the spacecraft crossing reconnection outflows while moving from one side of the X‐line to the other.
Large Modeling Uncertainty in Projecting Decadal Surface Ozone Changes Over City Clusters of China
Authors: Weng Xiang , Li Jiawei , Forster Grant L. , Nowack Peer 
Published: April 2023

AbstractClimate policies will affect future surface ozone pollution in China. Here, we simulate changes in summertime ozone across China by 2030 under four emission scenarios reflecting different levels of climate action. We also contrast results obtained with two different chemical mechanisms employed in the chemical transport model (WRF‐Chem). With emission reductions in ozone precursors introduced by climate policies, both mechanisms show promising ozone mitigation for most parts of China. However, they disagree starkly in China's three main city clusters, where one mechanism projects worsening ozone pollution by 2030 despite the emission reductions. We analyze possible drivers of this important discrepancy, in particular the role of varying ozone chemical regimes affecting its sensitivity to emission changes. We recommend an intercomparison project to examine this critical modeling uncertainty among other models/mechanisms, which would be invaluable for informing local and regional emission control strategies that are based on single‐model results.
Self-management with alcohol over lifespan: psychological mechanisms, neurobiological underpinnings, and risk assessment
Authors: Müller Christian P. , Schumann Gunter , Rehm Jürgen , Kornhuber Johannes , Lenz Bernd 
Published: April 2023

AbstractSelf-management includes all behavioural measures and cognitive activities aimed at coping with challenges arising throughout the lifespan. While virtually all of these challenges can be met without pharmacological means, alcohol consumption has long been instrumentalized as a supporting tool to help coping with problems arising selectively at adolescence, adulthood, and ageing. Here, we present, to our knowledge, the first systematic review of alcohol instrumentalization throughout lifespan. We searched MEDLINE, Google Scholar, PsycINFO and CINAHL (from Jan, 1990, to Dec, 2022) and analysed consumption patterns, goals and potential neurobiological mechanisms. Evidence shows a regular non-addictive use of alcohol to self-manage developmental issues during adolescence, adulthood, and ageing. Alcohol is selectively used to overcome problems arising from dysfunctional personality traits, which manifest in adolescence. A large range of psychiatric disorders gives rise to alcohol use for the self-management of distinct symptoms starting mainly in adulthood. We identify those neuropharmacological effects of alcohol that selectively serve self-management under specific conditions. Finally, we discuss the adverse effects and associated risks that arise from the use of alcohol for self-management. Even well-controlled alcohol use adversely impacts health. Based on these findings, we suggest the implementation of an entirely new view. Health policy action may actively embrace both sides of the phenomenon through a personalized informed use that allows for harm-controlled self-management with alcohol.
Grid integration feasibility and investment planning of offshore wind power under carbon-neutral transition in China
Authors: Guo Xinyang , Chen Xinyu , Chen Xia , Sherman Peter , Wen Jinyu , McElroy Michael 
Published: April 2023

AbstractOffshore wind power, with accelerated declining levelized costs, is emerging as a critical building-block to fully decarbonize the world’s largest CO2 emitter, China. However, system integration barriers as well as system balancing costs have not been quantified yet. Here we develop a bottom-up model to test the grid accommodation capabilities and design the optimal investment plans for offshore wind power considering resource distributions, hourly power system simulations, and transmission/storage/hydrogen investments. Results indicate that grid integration barriers exist currently at the provincial level. For 2030, optimized offshore wind investment levels should be doubled compared with current government plans, and provincial allocations should be significantly improved considering both resource quality and grid conditions. For 2050, offshore wind capacity in China could reach as high as 1500 GW, prompting a paradigm shift in national transmission structure, favoring long-term storage in the energy portfolio, enabling green hydrogen production in coastal demand centers, resulting in the world’s largest wind power market.
A precision environmental health approach to prevention of human disease
Authors: Baccarelli Andrea , Dolinoy Dana C. , Walker Cheryl Lyn 
Published: April 2023

AbstractHuman health is determined by the interaction of our environment with the genome, epigenome, and microbiome, which shape the transcriptomic, proteomic, and metabolomic landscape of cells and tissues. Precision environmental health is an emerging field leveraging environmental and system-level (‘omic) data to understand underlying environmental causes of disease, identify biomarkers of exposure and response, and develop new prevention and intervention strategies. In this article we provide real-life illustrations of the utility of precision environmental health approaches, identify current challenges in the field, and outline new opportunities to promote health through a precision environmental health framework.
Interface engineering of charge-transfer excitons in 2D lateral heterostructures
Authors: Rosati Roberto , Paradisanos Ioannis , Huang Libai , Gan Ziyang , George Antony , Watanabe Kenji , Taniguchi Takashi , Lombez Laurent , Renucci Pierre , Turchanin Andrey , Urbaszek Bernhard , Malic Ermin 
Published: April 2023

AbstractThe existence of bound charge transfer (CT) excitons at the interface of monolayer lateral heterojunctions has been debated in literature, but contrary to the case of interlayer excitons in vertical heterostructure their observation still has to be confirmed. Here, we present a microscopic study investigating signatures of bound CT excitons in photoluminescence spectra at the interface of hBN-encapsulated lateral MoSe2-WSe2 heterostructures. Based on a fully microscopic and material-specific theory, we reveal the many-particle processes behind the formation of CT excitons and how they can be tuned via interface- and dielectric engineering. For junction widths smaller than the Coulomb-induced Bohr radius we predict the appearance of a low-energy CT exciton. The theoretical prediction is compared with experimental low-temperature photoluminescence measurements showing emission in the bound CT excitons energy range. We show that for hBN-encapsulated heterostructures, CT excitons exhibit small binding energies of just a few tens meV and at the same time large dipole moments, making them promising materials for optoelectronic applications (benefiting from an efficient exciton dissociation and fast dipole-driven exciton propagation). Our joint theory-experiment study presents a significant step towards a microscopic understanding of optical properties of technologically promising 2D lateral heterostructures.
Layered BiOI single crystals capable of detecting low dose rates of X-rays
Authors: Jagt Robert A. , Bravić Ivona , Eyre Lissa , Gałkowski Krzysztof , Borowiec Joanna , Dudipala Kavya Reddy , Baranowski Michał , Dyksik Mateusz , van de Goor Tim W. J. , Kreouzis Theo , Xiao Ming , Bevan Adrian , Płochocka Paulina , Stranks Samuel D. , Deschler Felix , Monserrat Bartomeu , MacManus-Driscoll Judith L. , Hoye Robert L. Z. 
Published: April 2023

AbstractDetecting low dose rates of X-rays is critical for making safer radiology instruments, but is limited by the absorber materials available. Here, we develop bismuth oxyiodide (BiOI) single crystals into effective X-ray detectors. BiOI features complex lattice dynamics, owing to the ionic character of the lattice and weak van der Waals interactions between layers. Through use of ultrafast spectroscopy, first-principles computations and detailed optical and structural characterisation, we show that photoexcited charge-carriers in BiOI couple to intralayer breathing phonon modes, forming large polarons, thus enabling longer drift lengths for the photoexcited carriers than would be expected if self-trapping occurred. This, combined with the low and stable dark currents and high linear X-ray attenuation coefficients, leads to strong detector performance. High sensitivities reaching 1.1  × 103 μC Gyair−1 cm−2 are achieved, and the lowest dose rate directly measured by the detectors was 22 nGyair s−1. The photophysical principles discussed herein offer new design avenues for novel materials with heavy elements and low-dimensional electronic structures for (opto)electronic applications.
Pancreatic cancer is associated with medication changes prior to clinical diagnosis
Authors: Zhang Yin , Wang Qiao-Li , Yuan Chen , Lee Alice A. , Babic Ana , Ng Kimmie , Perez Kimberly , Nowak Jonathan A. , Lagergren Jesper , Stampfer Meir J. , Giovannucci Edward L. , Sander Chris , Rosenthal Michael H. , Kraft Peter , Wolpin Brian M. 
Published: April 2023

AbstractPatients with pancreatic ductal adenocarcinoma (PDAC) commonly develop symptoms and signs in the 1–2 years before diagnosis that can result in changes to medications. We investigate recent medication changes and PDAC diagnosis in Nurses’ Health Study (NHS; females) and Health Professionals Follow-up Study (HPFS; males), including up to 148,973 U.S. participants followed for 2,994,057 person-years and 991 incident PDAC cases. Here we show recent initiation of antidiabetic (NHS) or anticoagulant (NHS, HFS) medications and cessation of antihypertensive medications (NHS, HPFS) are associated with pancreatic cancer diagnosis in the next 2 years. Two-year PDAC risk increases as number of relevant medication changes increases (P-trend <1 × 10−5), with participants who recently start antidiabetic and stop antihypertensive medications having multivariable-adjusted hazard ratio of 4.86 (95%CI, 1.74–13.6). These changes are not associated with diagnosis of other digestive system cancers. Recent medication changes should be considered as candidate features in multi-factor risk models for PDAC, though they are not causally implicated in development of PDAC.
The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner
Authors: Gonzalez-Sandoval Adriana , Pekrun Katja , Tsuji Shinnosuke , Zhang Feijie , Hung King L. , Chang Howard Y. , Kay Mark A. 
Published: April 2023

AbstractRecombinant adeno-associated viral vectors (rAAVs) are among the most commonly used vehicles for in vivo based gene therapies. However, it is hard to predict which AAV capsid will provide the most robust expression in human subjects due to the observed discordance in vector-mediated transduction between species. In our study, we use a primate specific capsid, AAV-LK03, to demonstrate that the limitation of this capsid towards transduction of mouse cells is unrelated to cell entry and nuclear transport but rather due to depleted histone H3 chemical modifications related to active transcription, namely H3K4me3 and H3K27ac, on the vector DNA itself. A single-amino acid insertion into the AAV-LK03 capsid enables efficient transduction and the accumulation of active-related epigenetic marks on the vector chromatin in mouse without compromising transduction efficiency in human cells. Our study suggests that the capsid protein itself is involved in driving the epigenetic status of the vector genome, most likely during the process of uncoating. Programming viral chromatin states by capsid design may enable facile DNA transduction between vector and host species and ultimately lead to rational selection of AAV capsids for use in humans.