bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rollenverteilung bei Erstellung, Fortschreibung und Nutzung des Fachmodells Baugrund – Empfehlung Nr. 4 des Arbeitskreises 2.14 der DGGT „Digitalisierung in der Geotechnik“
Authors: Bauer Jörg , Henke Sascha , Klügel Silvio , Molzahn Michael , Tilger Klaus 
Published: June 2023

AbstractBei der klassischen Arbeitsweise im Bauwesen sind die Zuständigkeiten und Verantwortlichkeiten zwischen der geotechnischen Fachplanung, dem Auftraggeber und den weiteren Projektbeteiligten wie Planer und Bauausführung eindeutig festgelegt und haben sich bewährt. Jedoch wird im Infrastrukturbau zukünftig verpflichtend vom Sachverständigen für Geotechnik zusätzlich zum Geotechnischen Bericht auch das Fachmodell Baugrund eingefordert. Durch die Vernetzung dieses Fachmodells mit anderen Fachmodellen im Gesamtmodell wird sich für den Sachverständigen für Geotechnik damit voraussichtlich eine stärkere Einbindung und ein größerer Tätigkeitsumfang beim Planungs‐ und Realisierungsprozess einer Baumaßnahme über den gesamten Lebenszyklus ergeben. Zudem wird aufgrund der notwendigen Standardisierung der Modellstruktur aller Fachmodelle in einem BIM‐Projekt der Auftraggeber stärker in die Verantwortung gezogen. So sind vom Auftraggeber hinsichtlich der Modellstruktur auch klare Vorgaben für die Geotechnik zu formulieren. Die bisherigen Zuständigkeiten und Verantwortlichkeiten in einem Projekt werden erweitert und teilweise angepasst. Die vorliegende vierte Empfehlung des Arbeitskreises 2.14 der DGGT „Digitalisierung in der Geotechnik“ beschreibt die bei BIM‐Projekten vorhandene Organisationsstruktur und definiert die Zuständigkeiten und Verantwortlichkeiten bei der Bearbeitung des Fachmodells Baugrund.
MRI for Hepatitis B‐Associated Intrahepatic Cholangiocarcinoma: A Multicenter Comparative Study
Authors: Sheng Ruofan , Wang Heqing , Zhang Yunfei , Sun Wei , Jin Kaipu , Dai Yongming , Zhang Weiguo , Zeng Mengsu , Zhou Jianjun 
Published: June 2023

BackgroundThe diagnosis of intrahepatic cholangiocarcinoma (iCCA) is challenging in hepatitis B virus (HBV)‐infected patients, due to the overlapping clinical manifestations and atypical imaging patterns compared to patients without HBV.PurposeTo investigate the preoperative imaging characteristics of iCCA in patients with HBV in comparison to those without HBV.Study TypeRetrospective.Subjects431 patients with histopathologically confirmed iCCA (143 HBV‐positive and 288 HBV‐negative patients) were retrospectively enrolled from three institutes, and patients were allocated to the training (n = 302) and validation (n = 129) cohorts from different institutes or time period; 100 matching HBV‐positive hepatocellular carcinoma (HCC) patients were also enrolled.Field Strength/Sequence1.5‐T and 3‐T, including T1‐ and T2‐weighted, diffusion‐weighted and dynamic gadopentetate dimeglumine‐enhanced imaging.AssessmentClinical and MRI features were analyzed and compared between HBV‐positive and HBV‐negative patients with iCCA, and between HBV‐positive patients with iCCA and HCC.Statistical TestsUnivariate and multivariate logistic regression analyses with odds ratio (OR) to identify independent features for discriminating HBV‐associated iCCA. Diagnostic model generation by incorporating independent features, and the performance for discrimination was evaluated by receiver operating characteristics with the area under the curve (AUC) and 95% confidence interval (CI). AUCs were compared by the DeLong's method. A P‐value <0.05 was considered statistically significant.ResultsCompared to patients without HBV, washout or degressive enhancement pattern (OR = 51.837), well‐defined tumor margin (OR = 8.758) and no peritumoral bile duct dilation (OR = 4.651) were independent significant features for discriminating HBV‐associated iCCAs. All these features were also the predominant MRI manifestations for HBV‐associated HCC. The combined index showed an AUC of 0.798 (95% CI 0.748–0.842) in the training cohort and an AUC of 0.789 (95% CI 0.708–0.856) in the validation cohort for discrimination. The sensitivity, specificity, and accuracy were all >70%, which was superior to each single feature alone in both cohorts. [Correction added after first online publication on 29 June 2023. The Field Strength/Sequence has been updated from 5‐T to 1.5‐T.]Data ConclusionPreoperative MRI may help to discriminate HBV‐associated iCCA.Evidence Level3Technical Efficacy Stage2
Liberalized automatic generation control of interconnected thermal‐hydro‐gas system using firefly algorithm optimized PID controller
Authors: Khare Prashant , Raju More , Gupta Shiv Charan , Shukla Hiramani 
Published: June 2023

AbstractIn liberalized power system, the distribution companies are free to choose the contracts with all available generating companies (GENCOs), while the independent system operator acting as regulatory authority. In this article, the liberalized automatic generation control problem is studied for a two‐area interconnected power system. The studies are divided into two parts. In first part, the investigations are carried out with only thermal generations in each area. In second part, the multi‐diverse sourced thermal‐hydro‐gas GENCOs are assumed in each control area. For damping out the system frequency and tie‐line power dynamics, the popularly known PI and PID controllers are employed considering poolco, bilateral and contract violation transactions. In both the parts, the comparative performance between PI/PID controllers is made. Studies reveal that PID outperforms PI controller. A case study with introduction of time delay in the system is performed as the open communication infrastructure introduces inherent time delay in the smart grid scenario. To understand the impact of frequency sensitive loads on system dynamics, the effect of variation in damping coefficient (D) is studied and it is shown how the D is influencing the dynamics. The effect of double reheat turbines is also studied and found that they deteriorate the dynamics when compared to single reheat turbines. In all the above studies, the powerful nature inspired firefly algorithm is employed to optimize the parameters of controllers using the integral squared error method.
Seasonal sea breeze variation analysis based on multi‐year near‐surface observations in Jakarta, Indonesia
Authors: Junnaedhi I Dewa Gede Agung , Inagaki Atsushi , Ferdiansyah Muhammad Rezza , Kanda Manabu 
Published: June 2023

AbstractIn this study, multi‐year near‐surface observations were conducted at two sites in Jakarta, Indonesia to analyse seasonal sea breeze variation. Seasonal length was defined using observed zonal wind components, the rainy season was defined as December–March, and the dry season was defined as May–September. We found that the sea breeze in Jakarta started earlier, propagated more rapidly, and lasted for a shorter period of time during the rainy than dry season. Variation in the air temperature difference between urban and coastal areas of Jakarta was the major factor driving sea breeze seasonal variation. During the rainy season, night‐time cloud downwelling decreased this air temperature difference, causing earlier sea breeze onset and more rapid sea breeze propagation due to a weaker land breeze. By contrast, during the dry season, intense night‐time radiative cooling inland caused a strong negative temperature difference that produced a stronger land breeze, thus, slowing sea breeze propagation. Seasonal differences in urban surface heating and urban heat island circulation may also affect sea breeze onset and propagation speed. Discrepancies in thermal properties between urban core and coastal areas of Jakarta also prolonged positive temperature differences after sunset, thus extending the sea breeze duration in the dry season.
Comparison of statistical methods for integrating real‐world evidence in a rare events meta‐analysis of randomized controlled trials
Authors: Yao Minghong , Wang Yuning , Ren Yan , Jia Yulong , Zou Kang , Li Ling , Sun Xin 
Published: June 2023

AbstractRare events meta‐analyses of randomized controlled trials (RCTs) are often underpowered because the outcomes are infrequent. Real‐world evidence (RWE) from non‐randomized studies may provide valuable complementary evidence about the effects of rare events, and there is growing interest in including such evidence in the decision‐making process. Several methods for combining RCTs and RWE studies have been proposed, but the comparative performance of these methods is not well understood. We describe a simulation study that aims to evaluate an array of alternative Bayesian methods for including RWE in rare events meta‐analysis of RCTs: the naïve data synthesis, the design‐adjusted synthesis, the use of RWE as prior information, the three‐level hierarchical models, and the bias‐corrected meta‐analysis model. The percentage bias, root‐mean‐square‐error, mean 95% credible interval width, coverage probability, and power are used to measure performance. The various methods are illustrated using a systematic review to evaluate the risk of diabetic ketoacidosis among patients using sodium/glucose co‐transporter 2 inhibitors as compared with active‐comparators. Our simulations show that the bias‐corrected meta‐analysis model is comparable to or better than the other methods in terms of all evaluated performance measures and simulation scenarios. Our results also demonstrate that data solely from RCTs may not be sufficiently reliable for assessing the effects of rare events. In summary, the inclusion of RWE could increase the certainty and comprehensiveness of the body of evidence of rare events from RCTs, and the bias‐corrected meta‐analysis model may be preferable.
Impact of pomegranate fruit powder on dough, textural and functional properties of fresh noodle
Authors: Zhang Mengting , Peng Hong , Li Bin , Tian Jing 
Published: June 2023

AbstractBACKGROUNDPolyphenols are important functional food ingredients due to good performance in the prevention of chronic diseases and elongation of shelf‐life. Numerous studies have shown that the addition of polyphenols of natural origin to wheat flour tends to have a contradictory effect on the physicochemical properties of the dough in the presence of different doses of polyphenols, also known as biphasic regulation. In the meantime, a promising and economic flour enhancer of natural origin is needed because of the short stability time of the dough. In this study, the impact of pomegranate fruit powder (PFP) on mixing and rheological properties of the dough and texture as well as nutritional characteristics of cooking noodles was studied.RESULTSThe mixing and tensile properties as well as viscoelasticity of the dough were improved with the addition of 4%, 8% or 12% PFP; correspondingly, a more compact and ordered microstructure was observed in the dough. The addition of PFP maintained the best cooking time and water absorption of noodles. Moreover, the hardness, tensile strength and resilience of noodles were improved with the addition of 4% or 8% PFP. Furthermore, the antioxidant capacities of noodles with the addition of PFP were increased via quantification of iron ion reduction, DPPH and ABTS scavenging capacity. The noodles added with PFP showed a dose‐dependent inhibitory effect on glucose release.CONCLUSIONPFP improved the textural properties and nutrition value of noodles. The addition of PFP to the wheat four dough and noodles was suggested to be below 12%. © 2023 Society of Chemical Industry.
Primary cutaneous follicle centre lymphoma with secondary systemic evolution
Authors: Li Andy , Lehmann‐Che Jacqueline , Champ Jérôme , Rivet Jacqueline , Vignon‐Pennamen Marie‐Dominique , Mourah Samia , Cayuela Jean‐Michel , Lepelletier Clémence , Louveau Baptiste , Dumont Maëlle , Alhage Jana , Ram‐Wolff Caroline , Bouaziz Jean‐David , Bagot Martine , De Masson Adèle , Battistella Maxime 
Published: June 2023

AbstractPrimary cutaneous follicle centre lymphomas (PCFCLs) are cutaneous proliferation of centrocytes and centroblasts, with a generally indolent evolution. Secondary systemic spread of disease is a rare event, which significantly impairs prognosis. Recently published study by Zhou and al. proposed criteria aiming to predict such evolution at initial stage: (i) rearrangement of Bcl2, (ii) Ki67% index <30% and (iii) 2 mutations among the CREBBP, KMT2D, EZH2 and EP300.1 genes. We herein report two cases of PCFCLs with systemic evolution. Both patients had been initially diagnosed with localised skin disease, and developed, several years after, a secondary systemic involvement. Skin biopsies at the initial stage and systemic spread were analysed by histology, immunohistochemistry, fluorescence in situ hybridisation, and by DNA sequencing of a panel of 54 genes frequently mutated in lymphomas. Both patients showed no rearrangement of Bcl2, >30% Ki67% indexes and no mutations among the four proposed genes. These findings run contrary to these previously proposed criteria, highlighting the molecular heterogeneity of this rare disease.
Hunters' opposition to harmful hunting practices on ecosystems: values, beliefs, norms, and identities
Authors: Ghasemi Benjamin , Kyle Gerard T. 
Published: June 2023

AbstractIn North America, legal hunting is considered a key component in wildlife management and conservation; however, hunters' relationships with ecosystem health and integrity are rarely explored. In this study, we recruited an online panel of hunters in the United States (n = 508) in 2018 to assess their opinions about hunting‐related practices that often negatively affect biodiversity and ecosystem health (i.e., exotic breeding, stock breeding, and game farming). We investigated the underlying socio‐psychological factors influencing hunters' opinions about these practices based on the value‐belief‐norm and identity theories. Hunter identity, personal norms, and awareness of the negative consequences on ecosystems are associated with opposition to hunting‐related practices that harm ecosystems. We suggest that outreach and education programs targeting hunters should focus on leveraging their existing identities and promoting awareness of the negative consequences of certain hunting practices on biodiversity and ecosystem health. By highlighting these consequences and emphasizing the role of ecosystem health and biodiversity in the long‐term sustainability of hunting opportunities, such programs can effectively encourage hunters to adopt ecosystem stewardship behaviors.
Wildlife studies on the Tongass National Forest challenge essential assumptions of its wildlife conservation strategy
Authors: Smith Winston P. , Flaherty Elizabeth A. 
Published: June 2023

AbstractThe Tongass National Forest in southeast Alaska, USA, includes the Alexander Archipelago and narrow North American mainland, comprising one of the largest remaining, largely pristine, coastal temperate rainforest in the world. Management of the Tongass has become increasingly challenging because of expectations of a conservation framework designed to maintain viable populations of native wildlife species while decades of extensive clearcut logging of old‐growth forests has continued. We used the findings of multiple published studies conducted on the Tongass from 1998 to 2017 to examine 4 assumptions of its wildlife conservation strategy (WCS): forest planning assessments of wildlife viability were realistic, forest management and conservation policies are implemented at appropriate ecological scales, old‐growth reserves are effective habitat conservation areas and ensure functional connectivity, and forest‐wide standards and guidelines ensure sufficient habitat for sensitive species in managed landscapes. Several ecological field studies, population and spatial analyses and modeling, and statistical analyses revealed that wildlife viability assessments to evaluate forest plan alternatives underestimated the risk of extinction by only examining individual vulnerable species rather than considering joint probabilities across multiple species; the ecological scale of management and conservation policies do not adequately consider area‐sensitive vulnerabilities of island communities as evidenced by the increasing risk of extirpation of island endemics whose populations have become isolated and reduced; old‐growth reserves are unlikely to maintain viable populations of endemic small mammals in isolation or as functionally connected metapopulations; and a spatially explicit analysis of individual home ranges demonstrated that forest‐wide standards and guidelines provide about half the breeding habitat needed by a federally listed endemic raptor, the Queen Charlotte goshawk(Accipiter gentilis laingi), of which only half of that is secure. Thus, assertions that the WCS is properly functioning as designed are dubious because a comprehensive monitoring plan has not been implemented and vital underlying assumptions are not supported by available science. We recommend 3 forest management and conservation policy adjustments: limit size and location old‐growth forest harvests, restore forests through intermediate stand management of second growth, and conduct a formal review of WCS elements and assumptions.
Three‐dimensionally visualized ossification and mineralization process of the otic capsule in a postnatal developmental mouse
Authors: Bai Jing , Ito Taku , Fujikawa Taro , Honda Keiji , Kawashima Yoshiyuki , Watanabe Hiroki , Kurata Natsuko , Tsutsumi Takeshi 
Published: June 2023

AbstractObjectiveWe aimed to elucidate the ossification process of the otic capsule in postnatal C57BL/6 mice and depict the three‐dimensional (3D) process of otoconial mineralization in vivo.MethodsThe otic capsules of C57BL/6 mice were stained with alizarin red and imaged/compared using micro‐computed tomography on postnatal day (P) between P0 and P8, P10, P15, and P30 and 3–4 months old (P3–4Mo). We reconstructed 3D images of the otic capsule and otoconia and measured the bone mineral density using x‐ray absorptiometry on each age.ResultsThe 3D reconstructed otic capsule images revealed two ossification centers of the otic capsule at P0. One was observed around the ampulla of the superior semicircular canal and utricle, and the other was observed around the ampulla of the posterior semicircular canal. The cross‐sectional views demonstrated that modiolar ossification developed from the base to the apex from P4 to P8. The inter‐scalar septum ossified bidirectionally from the modiolus and bony otic capsule from P8 to P15. The mineralized otoconia were first detected in the utricle at P3 and saccular otoconia at P6. The density of the utricle and saccular otoconia showed different growth trends.ConclusionTo the best of our knowledge, this is the first study to demonstrate the 3D appearance of the otic capsule and otoconia in different developmental stages of mice. We also revealed that modiolar and inter‐scalar septal calcification is the final event in the cochlea and that it can be susceptible to pathological conditions (cochlear congenital malformations and hereditary vestibular diseases). The unique features of the ossification process and duration may explain these pathological conditions observed in humans.Level of Evidence3
Evaluation of a commercial graphene‐additive for boosting the corrosion performance of a thermal curing primer
Authors: Wiener Simon , Strauß Bernhard , Luckeneder Gerald , Hagler Josef , Valtiner Markus 
Published: June 2023

AbstractGraphene has emerged as a promising additive for improving the corrosion resistance of organic coatings due to its planar structure and low permeability. Multiple publications have reported positive results, primarily because of its barrier qualities. However, the incorporation of graphene into commercial coatings has not been studied in great detail, as the limited availability of commercial‐grade graphene has hindered its widespread use. This study investigates the addition of a commercially available graphene additive to a commercial primer, using industry‐standard corrosion tests and advanced characterization techniques to evaluate the coating's performance. The results show that while the addition does improve the barrier properties of the coating, as shown in salt spray tests, it also reduces its functionality due to factors such as oxygen reduction on graphene and accelerated diffusion pathways. Overall, the cost of incorporating graphene may outweigh the limited benefits observed in this study. These findings underscore the need for further research to explore the potential of graphene and the importance of utilizing multiple testing methods for performance evaluation.
Anodal Cerebellar Transcranial Direct Current Stimulation Reduces Motor and Cognitive Symptoms in Friedreich's Ataxia: A Randomized, Sham‐Controlled Trial
Authors: Naeije Gilles , Rovai Antonin , Destrebecq Virginie , Trotta Nicola , De Tiège Xavier 
Published: June 2023

AbstractBackgroundFriedreich Ataxia is the most common recessive ataxia with only one therapeutic drug approved solely in the United States.ObjectiveThe aim of this work was to investigate whether anodal cerebellar transcranial direct current stimulation (ctDCS) reduces ataxic and cognitive symptoms in individuals with Friedreich's ataxia (FRDA) and to assess the effects of ctDCS on the activity of the secondary somatosensory (SII) cortex.MethodsWe performed a single‐blind, randomized, sham‐controlled, crossover trial with anodal ctDCS (5 days/week for 1 week, 20 min/day, density current: 0.057 mA/cm2) in 24 patients with FRDA. Each patient underwent a clinical evaluation (Scale for the Assessment and Rating of Ataxia, composite cerebellar functional severity score, cerebellar cognitive affective syndrome scale) before and after anodal and sham ctDCS. Activity of the SII cortex contralateral to a tactile oddball stimulation of the right index finger was evaluated with brain functional magnetic resonance imaging at baseline and after anodal/sham ctDCS.ResultsAnodal ctDCS led to a significant improvement in the Scale for the Assessment and Rating of Ataxia (−6.5%) and in the cerebellar cognitive affective syndrome scale (+11%) compared with sham ctDCS. It also led to a significant reduction in functional magnetic resonance imaging signal at the SII cortex contralateral to tactile stimulation (−26%) compared with sham ctDCS.ConclusionsOne week of treatment with anodal ctDCS reduces motor and cognitive symptoms in individuals with FRDA, likely by restoring the neocortical inhibition normally exerted by cerebellar structures. This study provides class I evidence that ctDCS stimulation is effective and safe in FRDA. © 2023 International Parkinson and Movement Disorder Society.