bluuebunny/crossref_metadata_2025_split huggingface dataset:
“The baze is our workstation, we report here every day”—Understanding the Role of Youth Practices in Urban Subculture
Authors: Muhando Isaac 
Published: August 2023

Abstract
Contemporary globalisation and urbanisation continue to play a significant role in how the youths (re)create and (re)define urban spaces in Africa. Major cities across the continent are becoming active sites for social and cultural transformation. With the economic slowdown and increased rate of unemployment, youths are seeking ways to adapt to these realities while at the same time staying true to their urban identity. The present study uses participatory observation to examine two of the emerging youth practices in Nairobi, which are, the baze and gengetone music, to underscore how the youths in Nairobi Eastlands engage these practices both as sites for bolstering their urban identity and as alternative spaces for earning a livelihood. The study reveals that both the baze and gengetone music are available platforms which city youths use to construct their urban identities while dealing with local social challenges such as alcoholism, drug abuse and negative ethnicity, as well as harsh economic realities such as unemployment and a high cost of living. Further examination shows that discourse spaces created by these practices afford them a chance to participate in matters of national interest where they can contest and challenge social orders that are oppressive.
Il n’y a pas à dire, un marqueur discursif du refus de contestation
Authors: Ramos Sañudo Ana María 
Published: August 2023

Abstract
This work presents an analysis of the marker il n’y a pas à dire from different perspectives. First, we study its lexicographical treatment in nine dictionaries and its presence in our corpus of written examples of contemporary French. Then, we consider the morphosyntactic and semantic-pragmatic attributes that make it an epistemic marker of the indisputable. With il n’y a pas à dire speakers consider the enunciative content as something undeniable: by using this linguistic unit they protect themselves behind the knowledge that is supposed to be shared with the community they belong to, so a personal assertion can be presented as if it were something already accepted, to which there could be no objection. The commitment to the content modalised by il n’y a pas à dire is thus intensified, because the speakers, who are committed to what they are saying, want to be assertive in the eyes of their interlocutors in order to have this content admitted.
Approche sémantique et contrastive des connecteurs français en fait et italien infatti : la proximité morphologique révèle-t-elle une proximité sémantique?
Authors: Chériaa Najah 
Published: August 2023

Abstract
This article is focusing on the following question: to what extent the morphological proximity between the french linguistic connector en fait and the italian linguistic connector infatti reveals a semantic proximity? In the framework of a lexical analysis, the prepositions en and in, as well as fait and fatti, it is needed to verify that the possibility of use of a connector can be determined by various parameters combining the semantic, lexical and morphological aspects. It is also important to highlight that both the French and Italian connectors are not always used within similar contexts and that the semes in the nominal core and in the preposition persist more in en fait than in infatti.
Vierordt’s Law for Space and Time: Hollingworth (1909) and “The Law of Central Tendency”
Authors: Wearden John H. 
Published: August 2023

Abstract
This article discusses material in a 1909 monograph, The Inaccuracy of Movement with Special Reference to Constant Errors, by H. L. Hollingworth, which is mostly concerned with demonstrating and accounting for what we would now call Vierordt’s Law, for judgements of both length and time. Hollingworth demonstrates Vierordt’s Law for a length reproduction task, and shows that the length which is reproduced most accurately (the indifference point) varies as a function of the range of the lengths presented. Hollingworth attributes this effect to the influence of the central tendency of the stimuli presented. He notes that this effect could be found in previous studies of time interval reproduction, but was not remarked upon. A second study also introduced error monitoring for length and time judgements. Hollingworth’s ideas echo much more recent approaches to Vierordt’s Law, some of which also use the idea that the Vierordt effect is based on the central tendency of the stimulus range from which the stimuli to be judged come.
Cholecystitis induced by Yttrium-90 radioembolization of advanced liver tumors: prospective evaluation of a management algorithm in 197 consecutive patients
Authors: Damm Robert , Bregenzer Carola , Steffen Ingo , Amthauer Holger , Seidensticker Ricarda , Seidensticker Max , Omari Jazan , Ricke Jens , Pech Maciej 
Published: August 2023

Background Cholecystitis is a rare but dolorous complication after Y90-radioembolization of liver malignancies. Purpose To decide the occlusion of the cystic artery (CA) to prevent cholecystitis after Y90 radioembolization using an algorithm. Material and Methods In 130 patients, the gallbladder was at risk of embolization as the right liver lobe was targeted. Precautionary measures (e.g. coil occlusion of the cystic artery) were decided by enhancement of the gallbladder in pre-treatment Tc99m-MAA SPECT/CT and performed directly before Y90 radioembolization. In non-enhancing cases, the CA was left open. The outcome was determined by clinical symptoms of acute or chronic cholecystitis as well as imaging and laboratory parameters. Findings were additionally classified according to the Tokyo Guidelines of acute cholecystitis. Results Only 16 patients demonstrated enhancement of the gallbladder in Tc99m-MAA SPECT/CT. Including additional indications from angiographic findings, prophylactic measures were scheduled in 22 patients (standard of care). Thus, 121 patients were at risk of non-target embolization to the gallbladder during Y90 microsphere administration (investigative arm). Four cases (3.0%) of cholecystitis occurred by clinical presentation: two patients with onset of acute symptoms within 48 h after Y90 radioembolization (“embolic cholecystitis”) and two patients with late onset of symptoms (“radiogenic cholecystitis”). The incidence of cholecystitis was not significantly more frequent without indication of precautionary measures (investigative cohort 2.9% vs. standard of care 4.7%; P = 0.53). Conclusion The overall incidence of cholecystitis after Y90 radioembolization is low. Determination of cystic artery intervention using Tc99m-MAA SPECT/CT successfully balances the incidence of symptomatic cholecystitis with unnecessary vessel occlusion.
Positive independent association between preoperative endogenous testosterone density and tumor load density in surgical specimen of patients undergoing radical prostatectomy
Authors: Porcaro Antonio Benito , Bianchi Alberto , Gallina Sebastian , Serafin Emanuele , Mazzucato Giovanni , Panunzio Andrea , Tafuri Alessandro , Montanaro Francesca , Marafioti Patuzzo Giulia , Baielli Alberto , Artoni Francesco , Vidiri Stefano , Cianflone Francesco , D’Aietti Damiano , Brunelli Matteo , Siracusano Salvatore , Cerruto Maria Angela , Antonelli Alessandro 
Published: August 2023

Objective: To evaluate the influence of endogenous testosterone density (ETD) and tumor load density (TLD) in the surgical specimen of prostate cancer (PCa) patients. Methods: ETD was assessed as the ratio of endogenous testosterone (ET) to prostate volume (PV). TLD was calculated as the ratio of tumor load (TL) to prostate weight. Preoperative prostate-specific antigen relative densities (PSAD) and percentage of biopsy-positive cores (BPCD) were also assessed. The association of high TLD (above the first quartile) with clinical and pathological factors was assessed by the logistic regression model (univariate and multivariate analysis). Results: Between November 2014 and December 2019, ET was measured in 805 cases treated with radical prostatectomy (RP). Median (IQR) of ET and ETD was 412 (321.4–519 ng/dL) and 9.8 (6.8–14.4 ng/(dLxmL)) as well as for TL and TLD was 20 (10-30%) and 0.33 (0.17-0.58%/gr), respectively. As a result, high TLD was detected in 75% of cases. A positive independent association was found between high TLD and ETD. Accordingly, as ETD levels increased, the risk of detecting high TLD in the surgical specimen increased, regardless of PSAD and BPCD. Conclusions: At diagnosis of PCa, a positive independent association was found between ETD and risk of high TLD. Subjects with increasing ETD levels were more likely to have high TLD, associated with unfavorable pathology features. The positive association between ETD and TLD in the prostate microenvironment might adversely influence PCa’s natural history.
Healthcare Utilization and Advance Care Planning among Older Adults Across Cognitive Levels
Authors: Rahemi Zahra , Malatyali Ayse , Bacsu Juanita-Dawne R. , Sefcik Justine S. , Petrovsky Darina V. , Baker Zachary G. , Ma Kris Pui Kwan , Smith Matthew L. , Adams Swann A. 
Published: August 2023

This study examined the impact of advance care planning (ACP) on healthcare utilization among older adults with normal cognition and impaired cognition/dementia. Using datasets from the Health and Retirement Study, we conducted a cross-sectional study on 17,698 participants aged 51 years and older. Our analyses included survey descriptive and logistic regression procedures. ACP measures included a living will and durable power of attorney for healthcare. Healthcare utilization was measured using the days spent in hospitals, hospice care, nursing homes, and home care. Of the participants, 77.8% had normal cognition, and 22% had impaired cognition/dementia. The proportion of impaired cognition/dementia was higher among racially minoritized participants, single/widowed participants, and those who lived alone and were less educated. The results showed that having an ACP was associated with longer stays in hospitals, nursing homes, and home healthcare in all participants.
Exploring the potential of magnesium oxychloride, an amorphous magnesium phosphate, and newberyite as possible bone cement candidates
Authors: Kaiser Friederike , Schröter Lena , Wohlfahrt Philipp , Geroneit Isabel , Murek Jérôme , Stahlhut Philipp , Weichhold Jan , Ignatius Anita , Gbureck Uwe 
Published: August 2023

Magnesium phosphate-based bone cements, particularly struvite (MgNH4PO4∙6H2O)-forming cements, have attracted increased scientific interest in recent years because they exhibit similar biocompatibility to hydroxyapatite while degrading much more rapidly in vivo. However, other magnesium-based minerals which might be promising are, to date, little studied. Therefore, in this study, we investigated three magnesium-based bone cements: a magnesium oxychloride cement (Mg3(OH)5Cl∙4H2O), an amorphous magnesium phosphate cement based on Mg3(PO4)2, MgO, and NaH2PO4, and a newberyite cement (MgHPO4·3H2O). Because it is not sufficiently clear from the literature to what extent these cements are suitable for clinical use, all of them were characterized and optimized regarding setting time, setting temperature, compressive strength and passive degradation in phosphate-buffered saline. Because the in vitro properties of the newberyite cement were most promising, it was orthotopically implanted into a partially weight-bearing tibial bone defect in sheep. The cement exhibited excellent biocompatibility and degraded more rapidly compared to a hydroxyapatite reference cement; after 4 months, 18% of the cement was degraded. We conclude that the newberyite cement was the most promising candidate of the investigated cements and has clear advantages over calcium phosphate cements, especially in terms of setting time and degradation behavior.
Role of hypoxia inducible factor/vascular endothelial growth factor/endothelial nitric oxide synthase signaling pathway in mediating the cardioprotective effect of dapagliflozin in cyclophosphamide-induced cardiotoxicity
Authors: Mahmoud Refaie Marwa Monier , Bayoumi Asmaa MA , Mokhemer Sahar Ahmed , Shehata Sayed , Abd El-Hameed Nahla Mohammed 
Published: August 2023

Background Cyclophosphamide (CP) is a commonly used chemotherapeutic and immunosuppressive alkylating agent. However, cardiac adverse effects of CP interfere with its clinical benefit. Cardio-oncology research is currently an important issue and finding effective cardiopreserving agents is a critical need. For the first time, we aimed to detect if dapagliflozin (DAP) could ameliorate CP-induced cardiac injury and investigated the role of hypoxia inducible factor α (HIF1α)/vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS) pathway. Methods Forty male Wistar albino rats were included in the current model. Studied groups are: control group; CP-induced cardiotoxicity group; CP group treated with DAP; CP group treated with DAP and administered a nitric oxide synthase inhibitor; nitro-ω-L-arginine (L-NNA) before DAP to explore the role of eNOS. Results Our data revealed that CP could induce cardiac damage as manifested by significant increases in cardiac enzymes, blood pressure, malondialdehyde (MDA), tumor necrosis factor alpha (TNFα), HIF1α, sodium glucose co-transporter 2 (SGLT2) and cleaved caspase-3 levels with toxic histopathological changes. However, there are significant decreases in reduced glutathione (GSH), total antioxidant capacity (TAC), VEGF, and eNOS. On the opposite side, co-administration of DAP showed marked improvement of CP-induced cardiac damage that may be due to its ability to inhibit SGLT2, antioxidant, anti-inflammatory and anti-apoptotic properties. Results showed decreasing the cardioprotective effect of DAP on administration of L-NNA, reflecting the critical effect of eNOS in mediating such protection. Conclusion DAP could reduce CP cardiotoxicity based upon its ability to modulate SGLT2 and HIF1α/VEGF/eNOS signaling pathway.
Clinicopathologic and Immunophenotypic Classification of Invasive Lobular Carcinoma with Histiocytoid Features
Authors: Coty-Fattal Zachary , Minhas Shubhanjali , Butcher Monica , Agarwal Indu , LaBoy Carissa , Blanco Luis , Novo Jorge 
Published: August 2023

Introduction Histiocytoid lobular breast carcinoma is a rare subtype of invasive lobular carcinoma characterized by relatively bland, uniform nuclei, single small eosinophilic nucleolus, and ample granular cytoplasm. These cancers are typically triple negative, show frequent androgen receptor (AR) positivity, and are therefore theorized to represent a variant of apocrine differentiation in invasive lobular carcinoma. Anecdotal evidence suggests that these tumors have excellent outcomes, though some studies suggest a variable clinical outcome. Methods Inclusion criteria included women with a histologic diagnosis of invasive lobular carcinoma with histiocytoid features, regardless of immunohistochemical profile, diagnosed at our institution between 2008 and 2021 with additional tissue still available for ancillary studies. We reviewed patients meeting these criteria and investigated hematoxylin and eosin-stained slides and a panel of immunohistochemical stains (estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 [HER2], AR, endothelial growth factor receptor, and keratin 5/6), as well as outcomes including survival and metastatic disease. Results Overall, 12 eligible patients were identified. The classical immunophenotype (triple negative with AR positivity) was noted in 4 out of 12 tumors. The majority of the remaining tumors (7 out of 12) showed a luminal B immunohistochemical profile, while 1 out of 12 was HER2-enriched. No patients in the cohort died from disease-related causes and 2 out of 12 presented with distant metastatic disease during their disease course. Conclusion Histiocytoid lobular breast carcinoma is a morphologic variant of lobular carcinoma with apocrine features that shows a variable immunohistochemical profile and variable clinical behavior. Further subclassification and stricter diagnostic criteria may be helpful in the distinction between truly indolent tumors and those with more aggressive clinical features.
Psoas muscle analysis as a surrogate marker of sarcopenia and frailty: A multicenter analysis of predictive capacities over short- and long-term outcomes after abdominal aortic aneurysm repair
Authors: Vázquez Pérez Rocío , Álvarez Marcos Francisco , Tello Díaz Cristina , Bellmunt Montoya Sergi , Fernández-Samos Gutiérrez Rafael , Gil Sala Daniel 
Published: August 2023

Objectives Several predictive models exist for estimating the postoperative risks of abdominal aortic aneurysm (AAA) repair, although no particular tool has seen widespread use. We present the results of a multicenter, historic cohort study comparing the predictive capacity of the psoas muscle area (PMA), radiodensity (PMD), and lean muscle area (LMA) as surrogate markers of sarcopenia, over short- and long-term outcomes after AAA repair, compared to the mFI-5 and American Society of Anesthesiologists (ASA) scales. Methods Retrospective review was conducted of all consecutive AAA elective repair cases (open or endovascular) in three tertiary-care centers from 2014 to 2019. Cross-sectional PMA, PMD, and LMA at the mid-body of the L3 vertebra were measured by two independent operators in the preoperative computed tomography. Receiver operating characteristic (ROC) curves were used to determine optimal cutoff values. Bivariate analysis, logistic regression, and Cox’s proportional hazards models were built to examine the relationship between baseline variables and postoperative mortality, long-term mortality, and complications. Results 596 patients were included (mean age 72.7 ± 8 years, 95.1% male, 66.9% EVAR). Perioperative mortality was 2.3% (EVAR 1.2% vs open repair 4.6%, p = .015), and no independent predictors could be identified in the multivariate analysis. Conversely, an age over 74 years old (OR 1.84 95%CI 1.25–2.70), previous heart diseases (OR 1.62 95%CI 1.13–2.32), diabetes mellitus (OR 1.61 95%CI 1.13–2.32), and a PMD value over 66 HU (OR 0.58 95%CI 0.39–0.84) acted as independent predictors of long-term mortality in the Cox’s proportional hazards model. Heart diseases (congestive heart failure or coronary artery disease), serum creatinine levels over 1.05 mg/dL, and an aneurysm diameter over 60 mm were independent predictors of major complications. Conclusion Surrogate markers of sarcopenia had a poor predictive profile for postoperative mortality after AAA repair in our sample. However, PMD stood out as an independent predictor of long-term mortality. This finding can guide future research and should be confirmed in larger datasets.
Influence of a Concurrent Exercise Training Program on Health-Related Quality of Life During Advanced Pregnancy: The GESTAFIT Project
Authors: Marín-Jiménez Nuria , Baena-García Laura , Coll-Risco Irene , Flor-Alemany Marta , Castro-Piñero José , Aparicio Virginia A. 
Published: August 2023

Background: Health-related quality of life (HRQoL) may be altered during pregnancy due to pregnancy-related changes in all domains of women’s health. Hypothesis: A supervised concurrent exercise-training program from the 17th gestational week until birth positively influences HRQoL. Study Design: Randomized controlled trial. Level of Evidence: Level 1. Methods: Eighty-six pregnant women (age, 33.1 ± 4.6 years; prepregnancy body mass index, 23.5 kg/m2), divided into exercise (n = 41) and control (n = 45) groups, participated in this study (per-protocol basis). The exercise group followed a 60-min, 3 days/week, concurrent (aerobic + resistance) exercise training program. HRQoL was assessed with the 36-Item Short Form Health Survey (SF-36), where higher scores (0-100) indicate better HRQoL. Results: After adjusting for potential confounders, the exercise group decreased 16.1 points less than the control group in the SF-36 physical functioning domain [between-group differences (B): 95% confidence interval (CI), 9.02 to 23.22; P < 0.01], and 4.5 points less in the SF-36 physical component summary than the control group (between-group differences (B): 95% CI, 0.65 to 8.28; P = 0.02). Intention-to-treat basis analyses depicted similar results, where the exercise group decreased 10.03 points less than the control group the in the SF-36 social functioning domain (between-group differences (B): 95% CI, 0.39 to 19.68; P = 0.04). Conclusion: A supervised concurrent exercise training program ameliorates HRQoL decreases along gestation. Although HRQoL decreased throughout pregnancy in both groups, this impact was less in the exercise group, especially in the SF-36 physical functioning, the SF-36 social functioning, and the SF-36 physical component summary. Clinical Relevance: Healthcare providers may encourage pregnant women to exercise in this physiological stage for a better HRQoL throughout pregnancy. ClinicalTrials.gov Identifier: NCT02582567; Date of registration: 20/10/2015