bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posttraumatic Growth After Struggling With the Loss of a Parent in Young Adulthood
Authors: Lundberg Tina , Årestedt Kristofer , Olsson Mariann , Alvariza Anette , Forinder Ulla 
Published: June 2023

This study aims to examine posttraumatic growth and its associations with parental bereavement among adolescents and young adults. Fifty-five young adults who had lost a parent to cancer at least 2 months earlier and were about to attend a support group at a palliative care service were recruited. Data was collected through questionnaires before support group participation, about 5–8 months after the loss and at a 6-month follow-up, about 14–18 months after the loss. The result shows that the young adults experienced posttraumatic growth, mostly in the domains Personal strength and Appreciation of life. Posttraumatic growth was associated with bereavement outcomes, especially life satisfaction, a feeling of meaning in future life and psychological health. The result is of value for health care professionals as it adds information about the importance of supporting constructive rumination to enhance the possibility to positive psychological change after a parent’s death.
Cross-Validating the Executive Errors Scale of the Repeatable Battery for the Assessment of Neuropsychological Status
Authors: Gradwohl Brian D. , Hale Andrew C. , Spencer Robert J. 
Published: June 2023

The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was developed to briefly measure a broad range of cognitive abilities, but it initially lacked a scale to evaluate executive functioning. Robert Spencer and colleagues recently created an Executive Errors scale (RBANS-EE) that quantified executive functioning (EF) errors committed during four RBANS subtests: List Learning, Semantic Fluency, Coding, and List Recall. In the present paper we cross-validated the RBANS-EE with a sample of 234 U.S. military veterans ( M AGE = 67.2, SD = 11.5 years; M EDUCATION = 13.3, SD = 2.4 years) who completed the RBANS and various EF criterion measures as part of neuropsychological assessments they underwent during their clinical care. We found the RBANS-EE to be significantly correlated with most of the criterion EF measures. The RBANS-EE scale demonstrated modest ability to classify EF impairment at mild and severe levels; and, similarly, the RBANS-EE was modestly capable of accurately classifying those veteran respondents who were determined to have or to not have a neurocognitive disorder. Overall, the RBANS-EE can be quickly calculated, adds no administration time to an RBANS assessment, and yields useful scores to screen for EF dysfunction without replacing standalone EF tests.
Galactose-functionalized injectable thermosensitive microgels for target specific uptake in hepatoma cells
Authors: Zhang Qianru , Zhu Lili , Zhang Tianyi , Quan Jing 
Published: June 2023

Microgels acts as a potential candidate for responsive composite materials, which has been favored by scientists because of its excellent colloid stability, easy integration, and most of their surface area can be used as support after modification. Specififically, microgels are fascinating capable of maintaining good biocompatibility and controlled-release in vivo and making the possible for applications in biomaterials and biomedicines. Besides, in the process of microgel synthesis, some targeting factors can be combined to achieve the purpose of cell targeting and uptake. Therefore, how to fundamentally design microgels is an urgent problem to be solved. In this study, we design and synthesize an injectable microgel P(DEGMA- co-OVNGal) that is made of 2-methyl-2-acrylate-2-(2-methoxy ethoxy) ethyl ester (DEGMA) and glycopolymer (OVNGal) that is thermoresponsive and contains galactose. When the content of crosslinking agent is regulated, the microgel will realize the transformation from sol to gel at the temperature around human body, causing the controlled release of the loaded drugs. With the increase of crosslinker content from 1% to 7%, the appearance of microgel changed from loose and ordered to compact and hard morphology, the swelling ratio of microgel decreased from 187% to 142%, and the phase volume transition temperature decreased from 29.2°C to 28°C. The results indicated that when the monomer ratio (DEGMA: OVNGal) increased from 2:1 to 40:1 with the amount of crosslinking agent at 1%, the particle size of microgel increased from 460 nm to 660 nm. In vitro released studies confirmed that the cumulative released DOX (doxorubicin, as a selected model drug) from the microgel can reach 50% after 7 days. Furthermore, in vitro experiments demonstrated that the injectable microgel P(DEGMA- co-OVNGal) can target HepG2 cells effectively and meantime dispalys excellent biocompatibility. Therefore, the injected microgels based on P(DEGMA- co-OVNGal) have the potential to serve as a robust and promising drug delivery carrier for targeted cancer therapy.
Psychiatric rehabilitation in secure forensic settings in NSW: Measuring outcomes
Authors: Burns Nicholas , Lyons Georgia , Dean Kimberlie 
Published: June 2023

Objective To quantify outcomes for patients of forensic psychiatric rehabilitation in NSW. Methods Data on 245 conditionally released forensic patients was extracted from the Mental Health Review Tribunal (MHRT) files and matched to several state-wide datasets. Descriptive statistics were generated to establish the cohort characteristics, rates of reoffending and social and clinical outcomes. Results At conditional release, social circumstances for the majority of patients were improved. Clinically, the cohort was more stable, though many did not remain stable over time. Only one-fifth of the sample received a further criminal charge. Conclusion Preliminary evidence suggests that forensic rehabilitation services in NSW are effective.
Preoperative assessment for vascular access: Vascular mapping and handgrip strength
Authors: Marques da Silva Bernardo , Fernandes João , Oliveira João , Silva Hugo , Fortes Alice , Lopes José António , Gameiro Joana 
Published: June 2023

Background: Reliable vascular access (VA) is required for patients receiving chronic hemodialysis (HD) treatment. Vascular mapping using duplex doppler ultrasonography (DUS) can aid in planning VA construction. Greater handgrip strength (HGS) was found to be associated with more developed distal vessels both in chronic kidney disease (CKD) patients and healthy individuals, and patients with lower HGS had worse morphologic vessel characteristics and were, therefore, less likely to construct distal VA. Objectives: This study aims to describe and analyze clinical, anthropometric, and laboratory characteristics of patients who underwent vascular mapping prior to VA creation. Research design: Prospective analysis. Subjects: Adult patients with CKD referred for vascular mapping, at a tertiary center, between March 2021 and August 2021. Measures: Preoperative DUS by a single experienced nephrologist was carried out. HGS was measured using a hand dynamometer, and PAD was defined as ABI < 0.9. Sub-groups were analyzed according to distal vasculature size (<2 mm). Results: A total of 80 patients were included, with a mean age of 65.7 ± 14.7 years; 67.5% were male, and 51.3% were on renal replacement therapy (RRT). Twelve (15%) participants had PAD. HGS was higher in the dominant arm (20.5 ± 12.0 vs 18.8 ± 11.2 kg). Fifty-eight (72.5%) patients had vessels smaller than 2 mm in diameter. There were no significant differences between groups concerning demographics or comorbidities (diabetes, HTN, PAD). HGS was significantly higher in patients with distal vasculature greater than or equal to 2 mm in diameter (dominant arm: 26.1 ± 15.5 vs 18.4 ± 9.7 kg, p = 0.010; non-dominant arm: 24.1 ± 15.3 vs 16.8 ± 8.6, p = 0.008). Conclusions: Higher HGS was associated with more developed distal cephalic vein and radial artery. Low HGS might be an indirect sign of suboptimal vascular characteristics, which might help predict the outcomes of VA creation and maturation.
Flexible modeling and dynamics simulation of four-bar beating-up system with clearance
Authors: Qiu Haifei , Huang Pengfei , Zhou Yanan , Zhang Hongwei 
Published: June 2023

To explore the actual working characteristic of the beating-up mechanism on looms, the Step function is adopted to convert the beating-up resistance to an equivalent torque acting on the rocking shaft, and a new method of calculating and simulating the resistance is hereby raised. In accordance with the two-state joint clearance, the paper establishes a double-side model of the four-bar beating-up system in clearance status via ADAMS/View software, and under the consideration of both beating-up resistance and flexible deformation conditions, the contact simulation of beating-up motion with different clearances (0.01∼0.12 mm) is achieved. The main findings are as follows: the actual working condition could be reflected more accurately if the beating-up resistance and component flexibility are included into the simulation computing; from the perspective of the impact on sley moving and beating-up loads, 0.08 mm clearance is obviously less then another three clearances (0.01 mm, 0.04 mm and 0.12 mm); the multi-point contact and collision with peak load greater than 4000 N is existed in connecting rod bearing in the 0∼350 Hz low frequency area, which is likely to exacerbate the wear and fatigue rupture of the bearing; the dynamic shock load of rocking shaft on the loom frame is far greater than that of the crankshaft, indicating that the rocking shaft is the main carrier for delivering the beating-up power; compared to the clearance of 0.08 mm and 0.12 mm, the dynamic impact load generated by the clearance of 0.01 mm and 0.04 mm on the loom frame is obvious greater. In addition, under the clearance condition, transverse vibration could be occurred for the flexible crankshaft due to the deviation of its centroid trajectory, which is detrimental to vibration and noise reduction for the loom system. On the basis of the work, a number of viewpoints with theoretical and practical significance could be provided to the design of beating-up system on the loom with clearance.
Gene Signatures for Latent Radiation-Induced Lung Injury Post X-ray Exposure in Mouse
Authors: Zhang Tongtong , Zhou Zhaoming , Wen Lei , Shan Changguo , Lai Mingyao , Liao Jing , Zeng Xin , Yan Gang , Cai Linbo , Zhou Meijuan , Wang Minghua 
Published: June 2023

Objective To investigate the X-ray-specific sensitive genes and potential signaling pathways involved in the latent period of radiation-induced lung injury (RILI) in mouse models. Method Mice were randomized into groups for whole thoracic irradiation with a single fraction of 20 Gy X-ray or 12.5 Gy carbon heavy ion. Lungs were harvested 3 weeks after the irradiation, whole RNA was extracted and detected with the genome-wide transcriptional microarrays. Differentially expressed genes (DEGs) were calculated for each group and the X-ray-specific sensitive genes were determined, followed by the gene enrichment analysis of those DEGs exploring the potentially relevant signaling pathways and biological processes in latent RILI. Results Three weeks after irradiation, gene expression levels varied between groups. 76 up-regulated DEGs were determined with mice in the X-ray group and gene ontology enrichment analysis for biological process (GO-BP) obtained several processes which were associated with radiation reaction, mitotic, immune cell chemotaxis or metastasis, immune factors, p53 apoptosis, and tissue remodeling. KEGG signaling pathway enrichment analysis showed that those 76 up-regulated DEGs were enriched in p53, IL-17, FoXO, melanoma, and non-small-cell lung cancer signaling pathways. By comparing the DEGs in X-ray and heavy ion groups, X-ray-specific sensitive genes were determined, the top 10 genes were Adamts9, Aacs, Col6a2, Fdps, Mdk, Mcam, Stbd1, Lbh, Ak3, and Emid1. The expression level of the top 10 genes was found to be significantly higher in the X-ray group than in the control and heavy ion groups. Conclusion Our research determined the X-ray-specific sensitive gene set in mice lungs after exposure to radiation. The gene set could be used as a genetic marker to suggest the latency of RILI. The enrichment analysis results suggested that the relevant signaling pathways were potentially involved in the development of RILI. Further validation of those genes and signaling pathways is needed to confirm these findings.
Esophageal secondary peristalsis following acid infusion and chemical clearance correlate with mucosal integrity and acid sensitivity in GERD patients
Authors: Wong Ming-Wun , Hung Jui-Sheng , Lei Wei-Yi , Liu Tso-Tsai , Yi Chih-Hsun , Liang Shu-Wei , Gyawali Chandra Prakash , Wang Jen-Hung , Chen Chien-Lin 
Published: June 2023

Background: Acid sensitivity can be altered in patients with gastroesophageal reflux disease (GERD). Secondary peristalsis helps clear gastro-esophageal refluxate and residual ingested food bolus. Objectives: The aim of this study was to investigate the associations among acid sensitivity, esophageal mucosal integrity, chemical clearance, and secondary peristalsis before and after esophageal acid infusion. Design: This was an investigator-initiated, prospective, cross-sectional study. Methods: Adult reflux patients underwent high resolution manometry and 24 h impedance-pH monitoring off acid suppression to identify GERD phenotypes, including non-erosive reflux disease (NERD), reflux hypersensitivity (RH), and functional heartburn (FH). Secondary peristalsis was assessed using five rapid 20 mL air injections into the esophagus before and after infusion of hydrochloric acid (0.1 N) into the mid-esophagus. Conventional acid infusion parameters recorded included lag time, intensity rating, and sensitivity score. Chemical clearance was evaluated using the post-reflux swallow-induced peristaltic wave (PSPW), and mucosal integrity was assessed by the mean nocturnal baseline impedance (MNBI) derived from impedance-pH monitoring. Results: A total of 88 patients (age 21–64 years, 62.5% women) completed the study including 12 patients with NERD, 45 with RH, and 31 with FH. There was no significant difference in acid infusion parameters between patients with NERD, RH, and FH. Upon acid infusion, patients who exhibited successful secondary peristalsis had longer lag time, higher MNBI, and shorter bolus contact time than those without secondary peristalsis. Meanwhile, patients with intact PSPW demonstrated significantly higher intensity ratings in response to acid perfusion and higher MNBI than those with impaired PSPW. The lag time correlated positively with MNBI ( r = 0.285; p = 0.007). Conclusion: In conclusion, the protective effect of esophageal secondary peristalsis and chemical clearance on esophageal mucosal integrity was demonstrated. Concerning acid sensitivity, longer lag time in patients with intact secondary peristalsis may be attributed to better esophageal mucosal integrity, while stronger intensity ratings may have a greater tendency to induce PSPW and protect esophageal mucosal integrity.
Human-directed aggression and pica in a 1-year-old cat, which worsened following international relocation
Authors: Jahn Katrin , DePorter Theresa , Seksel Kersti 
Published: June 2023

Case summary A 14-month-old female spayed Arabian Mau cat was presented for preparation for international air travel and relocation. It was also showing aggressive behaviours towards its owners and visitors to the home, with daily episodes of jumping at, scratching and biting the owners’ hands and legs. In addition, the cat was chewing on and ingesting wool and fabric items. Diagnoses of aggression occurring as misplaced play/predatory behaviour, fear-based aggression towards visitors and pica were made, and recommendations were given for both the behavioural presentations as well as to prepare for the family’s relocation to a new country and home. These recommendations included the use of long-acting psychotropic medications, which were declined at the time. After arrival in the new home, the cat’s aggression and pica worsened, so the owners requested a follow-up appointment. At this point, the selective serotonin reuptake inhibitor (SSRI) fluoxetine was initiated and after 6 weeks of medication, the owners reported a significant improvement in all behavioural signs. Relevance and novel information There is limited published information on the development and/or worsening of behaviour problems after stressful or traumatic events, such as international relocation. Furthermore, the management of concurrent behavioural presentations, such as, in this case, human-directed aggression and pica, can be challenging. This case provides an example of how this may be achieved. Finally, this case shows how the use of long-acting psychotropic medication, such as the SSRI fluoxetine, can be important and effective in managing feline behaviour problems.
Rates and Factors Associated With Hardware Removal in Physeal Ankle Fractures: Analysis of the Pediatric Health Information System
Authors: Pearce Robert J. , Cazzulino Alejandro , Swarup Ishaan 
Published: June 2023

Background: Ankle fractures are among the most common physeal fractures in children. When surgical management is warranted, subsequent hardware removal remains controversial. This study was designed to determine rates of hardware removal in patients with physeal ankle fractures and identify risk factors for removal. Procedure data was utilized to compare rates of subsequent ankle procedures in patients with hardware removed and hardware retained. Methods: We conducted a retrospective cohort study utilizing data from the Pediatric Health Information System (PHIS) for the years 2015 through 2021. We longitudinally followed patients treated for distal tibia physeal fractures to determine the rates of hardware removal and subsequent ankle procedures. Patients with open fractures or polytrauma were excluded. We used univariate, multivariate, and descriptive statistics to characterize the rates of hardware removal, identify factors associated with removal, and assess the rates of subsequent procedures. Results: This study included 1008 patients who underwent surgical management of a physeal ankle fracture. The mean age at index surgery was 12.6 years with an SD of 2.2 years, and 60% of patients identified as male. Two hundred forty-two patients (24%) had their hardware removed at an average time of 276 days (range, 21-1435 days) following index surgery. Patients with Salter Harris III (SH-III) or Salter Harris IV (SH-IV) fractures had hardware removed more often than patients with Salter-Harris II (SH-II) fractures (28.9% vs 11.7%, P < .01). Four-year rates of subsequent ankle procedures are similar between patients with hardware removed and hardware retained. Conclusion: The rate of hardware removal in children with physeal ankle fractures is higher than previously reported. Patients of younger age, higher income, and with fractures involving the epiphysis (SH-III and SH-IV) are more likely to undergo hardware removal. Level of Evidence: Level III, retrospective study.
Enhanced real-time mass spectrometry breath analysis for the diagnosis of COVID-19
Authors: Roquencourt Camille , Salvator Hélène , Bardin Emmanuelle , Lamy Elodie , Farfour Eric , Naline Emmanuel , Devillier Philippe , Grassin-Delyle Stanislas 
Published: June 2023

Background
Although rapid screening for and diagnosis of coronavirus disease 2019 (COVID-19) are still urgently needed, most current testing methods are long, costly or poorly specific. The objective of the present study was to determine whether or not artificial-intelligence-enhanced real-time mass spectrometry breath analysis is a reliable, safe, rapid means of screening ambulatory patients for COVID-19.

Methods
In two prospective, open, interventional studies in a single university hospital, we used real-time, proton transfer reaction time-of-flight mass spectrometry to perform a metabolomic analysis of exhaled breath from adults requiring screening for COVID-19. Artificial intelligence and machine learning techniques were used to build mathematical models based on breath analysis data either alone or combined with patient metadata.

Results
We obtained breath samples from 173 participants, of whom 67 had proven COVID-19. After using machine learning algorithms to process breath analysis data and further enhancing the model using patient metadata, our method was able to differentiate between COVID-19-positive and -negative participants with a sensitivity of 98%, a specificity of 74%, a negative predictive value of 98%, a positive predictive value of 72% and an area under the receiver operating characteristic curve of 0.961. The predictive performance was similar for asymptomatic, weakly symptomatic and symptomatic participants and was not biased by COVID-19 vaccination status.

Conclusions
Real-time, noninvasive, artificial-intelligence-enhanced mass spectrometry breath analysis might be a reliable, safe, rapid, cost-effective, high-throughput method for COVID-19 screening.
Quantitative99mTc-albumin colloid nasal mucociliary clearance as an outcome in primary ciliary dyskinesia
Authors: Marthin June K. , Nielsen Kim G. , Mortensen Jann 
Published: June 2023

BackgroundPrimary ciliary dyskinesia (PCD) is an inherited disorder in which dyskinetic cilia cause impaired mucociliary clearance of upper and lower airways. Airway ciliary movement can be indirectly testedin vivoafter administration of a radiolabelled tracer to the lower airways for assessment of pulmonary mucociliary clearance or to the nose for assessing nasal mucociliary clearance (NMC). With this study, we investigated NMC as a quantifiable study outcome parameter in patients with PCD.Material and methodsThis single centre proof-of-concept study on NMC velocity investigated patients with PCD across different genotypes and nasal nitric oxide (nasal NO) levels. Healthy controls were used for comparison. NMC was determined as velocity in mm·min−1of a nasally applied99mTc-albumin colloid tracer. Using a gamma camera, repeated dynamic series of images each lasting 30 s were acquired during a 10-minute period and digitally stored.ResultsNMC velocity was investigated in seven patients with PCD (aged 9–31 years) and five adult healthy controls. Mean NMC velocity in healthy controls (8.5 mm·min−1) was significantly higher compared with people with PCD (0.00 mm·min−1, p<0.0001). NMC was completely absent in all included patients with PCD across different PCD genotypes and regardless of nasal NO values. The success rate of the test was 100% in both groups.ConclusionNMC velocity discriminated highly significantly between patients with PCD and healthy controls. We suggest here a fast and feasible set up for NMC measurements that is easily applicable for any clinical trial involving PCD medication aimed for the nasal compartment, a step before or parallel to conducting clinical trials investigating whole-lung ciliary function in PCD.