bluuebunny/crossref_metadata_2025_split huggingface dataset:
ЕТИМОЛОГІЧНИЙ АСПЕКТ ВИВЧЕННЯ ДЕЯКИХ МЕДИЧНИХ ТЕРМІНІВ НА ПРАКТИЧНИХ ЗАНЯТТЯХ З УКРАЇНСЬКОЇ МОВИ
Authors: Зевако В. І. , Стефанишин К. Л. 
Published: September 2023

Анотація. У статті представлено систему післятекстових вправ і завдань, що розкривають лексико-семантичні можливості деяких медичних термінів із галузі фізичної терапії, ерготерапії, стоматології, фармації і спрямовані на розуміння їхньої етимології та творче засвоєння у процесі вивчення української мови (за професійним спрямуванням).
Зазначено, що за походженням, структурою, функціонуванням сучасна медична термінологія характеризується великим обсягом і різноманіттям. Для ефективного засвоєння фахових термінів передовсім необхідно забезпечити їхнє добре розуміння. З цією метою на практичному занятті, поруч з іншими видами аудиторної роботи, запроваджено й завдання етимологічної тематики.
Наголошено, що парадигматичні зв’язки мовних одиниць і систем найбільш повно реалізуються в тексті, тому під час практичних занять систематично використовуються текстові матеріали, дібрані з наукових, публіцистичних статей або інформаційних блоків спеціалізованих клінік і аптек, відповідним чином оформлені бібліографічно.
Розглянуто післятекстові завдання, репрезентовано фактичне наповнення, подекуди надано коментарі або відповіді до вправ. Зазначено, що аналізовані вправи і завдання були апробовані під час практичних занять з української мови (за професійним спрямуванням). Відзначено евристичний та ігровий елементи у процесі розв’язання.
Виявлено, що етимологічні відомості актуалізують міжпредметні зв’язки з латинською, англійською, німецькою мовами, спеціальними клінічними дисциплінами. Констатовано, що врахування інформації про походження медичних термінів сприяє їхньому осмисленому засвоєнню і вживанню, спонукає до пошуку першоджерел, розвиває міжпредметні зв’язки, а тому на заняттях з української мови (за професійним спрямуванням) важливо формувати основи етимологічних знань.
РОЗВИТОК РЕАБІЛІТАЦІЙНОГО МЕДСЕСТРИНСТВА В УКРАЇНІ: ПЕРСПЕКТИВИ, НАПРЯМИ ТА ВИКЛИКИ
Authors: Рудакова Н. Є. 
Published: September 2023

Анотація. У статті аналізується ефективність підготовки медичних сестер із реабілітації в Україні в контексті розвитку сучасної системи реабілітаційної допомоги.
Акцентується увага на ролі медичних сестер у наданні кваліфікованої допомоги та підтримці пацієнтів, особливо в умовах військового конфлікту в Україні у 2022 р. Зміни в концепції медсестринства, які передбачають більш активну участь пацієнтів у власному здоровʼї, вимагають перегляду освітніх програм та підготовки реабілітаційних медичних сестер. Основною метою дослідження є виявлення поточного стану підготовки фахівців, оцінка відповідності освітніх програм сучасній практиці та визначення можливих шляхів покращення процесу навчання.
Стаття розглядає важливість впровадження нових освітніх програм для підготовки компетентних медичних сестер із реабілітації, зокрема в контексті змін до Національного класифікатора професій та впровадження спеціалізації «Медична сестра/брат з реабілітації». Для успішного розвитку реабілітаційного медсестринства в Україні важливо проаналізувати наукові доробки вітчизняних фахівців та програми підготовки. Дослідження показало фрагментарне вивчення питання розвитку реабілітаційного медсестринства в Україні.
У статті зазначається, що реабілітаційне медсестринство є спеціалізованою галуззю, створеною для допомоги людям у відновленні функціональних можливостей та адаптації до нового життя. Щоб досягти успіху, необхідно впроваджувати світові практики та освітні програми з реабілітаційного медсестринства, які вже успішно функціонують у країнах Європи та Америки. Подальші дослідження можуть включати вивчення ролі медичних сестер/братів у реабілітаційній команді, розробку програм підвищення кваліфікації та оцінку впливу реабілітаційного медсестринства на покращення функціонування клієнтів.
A busca de si-mesmo e da identidade nas transformações corporais
Authors: Fulgencio Leopoldo , Humberg Lygia Vampré 
Published: September 2023

Este artigo procura analisar os principais acontecimentos e conquistas do processo de constituição da identidade no quadro da teoria do desenvolvimento emocional de Winnicott. Trata-se, em termos de caminho, ou método, de uma proposta de teoria psicanalítica aplicada à compreensão de fenômenos comportamentais de domínio público. Para analisarmos esse processo, apoiamo-nos na análise do sentido dado ao uso de tatuagens e de outras transformações corporais, nos casos em que estas implicam modificações que não seriam apenas adornos da pessoa, mas têm maior amplitude e podem estar a serviço de uma busca pela própria identidade. Consideramos que a identidade, ou sentimento de si mesmo identitário, está associada ao seguinte conjunto de experiências: a de ser, sem predicado; a de ser-com, associada aos fenômenos transicionais; a de ser-diferente-de, possível ao conquistar-se o status do eu sou; e a de ser-predicável, quando o indivíduo chegou à integração como uma pessoa inteira.

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Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension
Authors: Ranasinghe A. Dushani C.U. , Holohan Maggie , Borger Kalyn M. , Donahue Deborah L. , Kuc Rafael D. , Gerig Martin , Kim Andrew , Ploplis Victoria A. , Castellino Francis J. , Schwarz Margaret A. 
Published: September 2023

BACKGROUND:
Epigenetic regulation of vascular remodeling in pulmonary hypertension (PH) is poorly understood. Transcription regulating, histone acetylation code alters chromatin accessibility to promote transcriptional activation. Our goal was to identify upstream mechanisms that disrupt epigenetic equilibrium in PH.

METHODS:
Human pulmonary artery smooth muscle cells (PASMCs), human idiopathic pulmonary arterial hypertension (iPAH):human PASMCs, iPAH lung tissue, failed donor lung tissue, human pulmonary microvascular endothelial cells, iPAH:PASMC and non-iPAH:PASMC RNA-seq databases, NanoString nCounter, and cleavage under targets and release using nuclease were utilized to investigate histone acetylation, hyperacetylation targets, protein and gene expression, sphingolipid activation, cell proliferation, and gene target identification. SPHK2 (sphingosine kinase 2) knockout was compared with control C57BL/6NJ mice after 3 weeks of hypoxia and assessed for indices of PH.

RESULTS:
We identified that Human PASMCs are vulnerable to the transcription-promoting epigenetic mediator histone acetylation resulting in alterations in transcription machinery and confirmed its pathological existence in PH:PASMC cells. We report that SPHK2 is elevated as much as 20-fold in iPAH lung tissue and is elevated in iPAH:PASMC cells. During PH pathogenesis, nuclear SPHK2 activates nuclear bioactive lipid S1P (sphingosine 1-phosphate) catalyzing enzyme and mediates transcription regulating histone H3K9 acetylation (acetyl histone H3 lysine 9 [Ac-H3K9]) through EMAP (endothelial monocyte activating polypeptide) II. In iPAH lungs, we identified a 4-fold elevation of the reversible epigenetic transcription modulator Ac-H3K9:H3 ratio. Loss of SPHK2 inhibited hypoxic-induced PH and Ac-H3K9 in mice. We discovered that pulmonary vascular endothelial cells are a priming factor of the EMAP II/SPHK2/S1P axis that alters the acetylome with a specificity for PASMC, through hyperacetylation of histone H3K9. Using cleavage under targets and release using nuclease, we further show that EMAP II–mediated SPHK2 has the potential to modify the local transcription machinery of pluripotency factor KLF4 (Krüppel-like factor 4) by hyperacetylating KLF4 Cis-regulatory elements while deletion and targeted inhibition of SPHK2 rescues transcription altering Ac-H3K9.

CONCLUSIONS:
SPHK2 expression and its activation of the reversible histone H3K9 acetylation in human pulmonary artery smooth muscle cell represent new therapeutic targets that could mitigate PH vascular remodeling.
Fast bilateral weighted least square for the detail enhancement of COVID-19 chest X-rays
Authors: Bian Wenyan , Yang Yang 
Published: September 2023

Background X-ray is an effective measure in the diagnosis of coronavirus disease 2019. However, it suffers from low visibility and poor details. A plausible solution is to decompose the captured images and enhance the details. The bilateral weighted least square model can be an effective tool for this task. However, it is highly computationally expensive. Method In this article, we propose an efficient algorithm for the bilateral weighted least square model. We approximate the bilateral weight with the bilateral grid and then incorporate it into the optimization model. This significantly reduces the number of variables in the linear system. Therefore, the model can be efficiently solved. We employ the proposed algorithm to decompose the input X-rays into base and detail layers. The detail layers are then boosted and added back to the input to derive the detail-enhanced results. Results The subjective results indicate that our method achieves higher contrast than the best-performing method ([Formula: see text], [Formula: see text], [Formula: see text]). Furthermore, our method is highly efficient. It takes 0.92  s to process a 720P color image on an Intel i7-6700 CPU. The objective results derive from the chi-square test indicate that subjects hold more positive attitudes toward our detail-enhanced images than the original X-ray images ([Formula: see text], [Formula: see text], [Formula: see text]). Conclusion We have conducted extensive experiments to evaluate the proposed image detail enhancement method. It can be concluded that (1) our method could significantly improve the visibility of the X-ray images. (2) our method is fast and effective, thus facilitating real applications.
Multimorbidity transitions and the associated healthcare cost among the Finnish adult population during a two-year follow-up
Authors: Wikström Katja , Linna Miika , Reissell Eeva , Laatikainen Tiina 
Published: September 2023

Background Ageing of the population increases the prevalence and coexistence of many chronic diseases; a condition called multimorbidity. In Finland, information on the significance of multimorbidity and its relation to the sustainability of healthcare is scarce. Aim To assess the prevalence of multimorbidity, the transitions between patient groups with and without multiple diseases and the associated healthcare cost in Finland in 2017–2019. Methods A register-based cohort study covering all adults ( n = 3,326,467) who used Finnish primary or specialised healthcare services in 2017. At baseline, patients were classified as ‘non-multimorbid’, ‘multimorbid’ or ‘multimorbid at risk’ based on the recordings of a diagnosis of interest. The costs were calculated using the care-related patient grouping and national standard rates. Transition plots were drawn to observe the transition of patients and costs between groups during the two-year follow-up. Results At baseline, 62% of patients were non-multimorbid, 23% multimorbid and 15% multimorbid at risk. In two years, the proportion of multimorbid patients increased, especially those at risk. Within the multimorbid at-risk group, total healthcare costs were greatest (€5,027 million), accounting for 62% of the total healthcare cost of the overall patient cohort in 2019. Musculoskeletal diseases, cardiometabolic diseases and tumours were the most common and expensive chronic diseases contributing to the onset of multimorbidity. Conclusion Multimorbidity is causing a heavy burden on Finnish healthcare. The estimates of its effect on healthcare usage and costs should be used to guide healthcare planning.
Neither backlash nor convergence: dynamics of intra-couple childcare division during the Covid-19 pandemic in Germany
Authors: Boll Christina , Müller Dana , Schüller Simone 
Published: September 2023

AbstractUsing unique (bi)monthly panel data (IAB-HOPP) covering the immediate postlockdown period from June to August 2020, as well as the subsequent period up until the second lockdown in January/February 2021, we investigate opposing claims of widening/closing the gender gap in parental childcare during the Covid-19 pandemic in Germany. We consider prepandemic division as a reference point and provide dynamics rather than snapshots. Our results suggest a slight initial shift toward a more egalitarian division that, however, faded out in subsequent months. Starting from a fairly “traditional” prepandemic childcare division, the lockdown stimulus was not nearly strong enough to level the playing field. Subgroup analysis differentiating between individual lockdown-specific work arrangements shows that the drivers of the observed shift were mothers with relatively intense labor market participation who cannot work from home. Fathers’ work arrangement instead did not play a significant role. We conclude that the shift emerged out of necessity rather than opportunity, which makes it likely to fade once the necessity vanishes. Further, a shift is observed only if fathers were to some extent involved in childcare prepandemic, which points to the crucial role of initial conditions.
Management of respiratory failure in immune checkpoint inhibitors-induced overlap syndrome: a case series and review of the literature
Authors: Cuenca John A. , Hanmandlu Ankit , Wegner Robert , Botdorf Joshua , Tummala Sudhakar , Iliescu Cezar A. , Nates Joseph L. , Reddy Dereddi R. 
Published: September 2023

Abstract
Background
Checkpoint inhibitor-induced overlap syndrome ([OS] myocarditis, and myositis with or without myasthenia gravis) is rare but life-threatening.

Cases presentation
Here we present a case series of four cancer patients that developed OS. High troponinemia raised the concern for myocarditis in all the cases. However, the predominant clinical feature differed among the cases. Two patients showed marked myocarditis with a shorter hospital stay. The other two patients had a prolonged ICU stay due to severe neuromuscular involvement secondary to myositis and myasthenia gravis. Treatment was based on steroids, plasmapheresis, intravenous immunoglobulin, and immunosuppressive biological agents.

Conclusion
The management of respiratory failure is challenging, particularly in those patients with predominant MG. Along with intensive clinical monitoring, bedside respiratory mechanics can guide the decision-making process of selecting a respiratory support method, the timing of elective intubation and extubation.
A radiomics model fusing clinical features to predict microsatellite status preoperatively in colorectal cancer liver metastasis
Authors: Wang Xuehu , Liu Ziqi , Yin Xiaoping , Yang Chang , Zhang Jushuo 
Published: September 2023

Abstract
Purpose
To study the combined model of radiomic features and clinical features based on enhanced CT images for noninvasive evaluation of microsatellite instability (MSI) status in colorectal liver metastasis (CRLM) before surgery.

Methods
The study included 104 patients retrospectively and collected CT images of patients. We adjusted the region of interest to increase the number of MSI-H images. Radiomic features were extracted from these CT images. The logistic models of simple clinical features, simple radiomic features, and radiomic features with clinical features were constructed from the original image data and the expanded data, respectively. The six models were evaluated in the validation set. A nomogram was made to conveniently show the probability of the patient having a high MSI (MSI-H).

Results
The model including radiomic features and clinical features in the expanded data worked best in the validation group.

Conclusion
A logistic regression prediction model based on enhanced CT images combining clinical features and radiomic features after increasing the number of MSI-H images can effectively identify patients with CRLM with MSI-H and low-frequency microsatellite instability (MSI-L), and provide effective guidance for clinical immunotherapy of CRLM patients with unknown MSI status.
Synergy-based functional electrical stimulation and robotic-assisted for retraining reach-to-grasp in stroke: a study protocol for a randomized controlled trial
Authors: Zhou Huan-xia , Hu Jun , Yun Rui-sheng , Zhao Zhong-zhi , Lai Ming-hui , Sun Li-hui-zi , Luo Kai-liang 
Published: September 2023

Abstract
Background
Stroke survivors have long-term upper limb impairment, which impacts the quality of life (QOL) and social reintegration, but there is lack of effective therapeutic strategies and novel technologies. Customized multi-muscle functional electrical stimulation (FES) based on the muscle synergy of healthy adults and robotic-assisted therapy (RAT) have been proved efficacy respectively. Synergy-based FES combined with RAT can be a novel and more effective therapy for upper limb recovery of stroke survivors from the perspective of synergistic enhancement. However, few studies have examined the effectiveness of combined synergy-based FES and RAT, especially for motor control evaluated by reach-to-grasp (RTG) movements. The main objective of the following research protocol is to evaluate the effectiveness and efficacy, as well as adoptability, of FES-RAT and FES or RAT rehabilitation program for upper limb function improvement after stroke.

Methods
This will be an assessor-blinded randomized controlled trial involving a 12-week intervention and a 6-month follow-up. Stratified randomization will be used to equally and randomly assign 162 stroke patients into the FES + conventional rehabilitation program (CRP) group, RAT + CRP group and FES-RAT + CRP group. Interventions will be provided in 5 sessions per week, with a total of 60 sessions. The primary outcome measurements will include the Fugl-Meyer Assessment and Biomechanical Assessment of RTG movements. The secondary outcome measurements will include quality of life and brain neuroplasticity assessments by MRI. Evaluations will be performed at five time points, including at baseline, 6 weeks and 12 weeks from the start of treatment, and 3 months and 6 months following the end of treatment. A two-way analysis of variance with repeated measures will be applied to examine the main effects of the group, the time factor and group-time interaction effects.

Discussion
The results of the study protocol will provide high quality evidence for integrated synergy-based FES and RAT, and synergy-based FES alone and guide the design of more effective treatment methods for stroke rehabilitation.

Trial registration
ChiCTR2300071588.
Alternating electric fields can improve chemotherapy treatment efficacy in blood cancer cell U937 (non-adherent cells)
Authors: Homami Elham , Goliaei Bahram , Shariatpanahi Seyed Peyman , Habibi-Kelishomi Zahra 
Published: September 2023

Abstract
Background
Recent achievements in cancer therapy are the use of alternating electrical fields at intermediate frequencies (100–300 kHz) and low intensities (1–3 V/cm), which specifically target cell proliferation while affecting different cellular activities depending on the frequency used.

Methods
In this article, we examine the effect of electric fields on spherical suspended cells and propose the combination of Daunorubicin, a chemotherapy agent widely used in the treatment of acute myeloid leukemia, with electric field exposure. U937 cells were subjected to an electric field with a frequency of 200 kHz and an intensity of 0.75 V/cm, or to a combination of Daunorubicin and electric field exposure, resulting in a significant reduction in cell proliferation. Furthermore, the application of an electric field to U937 cells increased Daunorubicin uptake.

Results
Apoptosis and DNA damage were induced by the electric field or in conjunction with Daunorubicin. Notably, normal cells exposed to an electric field did not show significant damage, indicating a selective effect on dividing cancer cells (U937). Moreover, the electric field affects the U937 cell line either alone or in combination with Daunorubicin. This effect may be due to increased membrane permeability.

Conclusions
Our findings suggest that the use of electric fields at intermediate frequencies and low intensities, either alone or in combination with Daunorubicin, has potential as a selective anti-cancer therapy for dividing cancer cells, particularly in the treatment of acute myeloid leukemia. Further research is needed to fully understand the underlying mechanisms and to optimize the use of this therapy.
Infertility-related stress and its relationship with emotional divorce among Iranian infertile people
Authors: Shayesteh-Parto Fatemeh , Hasanpoor-Azghady Seyedeh Batool , Arefi Soheila , Amiri-Farahani Leila 
Published: September 2023

Abstract
Background
Infertility affects different aspects of couples’ lives, so it may cause problems in couples’ emotional relationships by increasing marital conflicts. This study aimed to determine Infertility-related stress and its relationship with emotional divorce among Iranian infertile people.

Methods
We conducted a cross-sectional observational study on 200 infertile people. The research environment was one of the well-equipped infertility centers in Tehran, Iran. Continuous sampling was employed. The data collection tools included a general information form, the Fertility Problem Inventory (FPI), and the Emotional Divorce Scale (EDS).

Results
The findings revealed a significant direct relationship between infertility-related stress and all its subscales with emotional divorce in both infertile women and men. In infertile women, the most concern was the need for parenthood, while the lowest concerns were the relationship and sexual concerns. Multiple linear regression analysis indicated that social and relationship concerns predicted 44% of emotional divorce, with social concern being the more influential factor. In infertile men, the need for parenthood was the most significant concern, while relationship and social concerns were less prominent. Multiple linear regression analysis showed that relationship concern predicted 50% of emotional divorce in infertile men. In both infertile men and women, social and relationship concerns explained 45% of the variance in emotional divorce. Among these two variables, relationship concern had a more impact in predicting emotional divorce. Also, there was no statistically significant difference between women and men regarding infertility-related stress and its subscales, except for sexual concern.

Conclusion
The study highlights the importance of the need for parenthood as a main concern among infertile individuals. Increased infertility-related stress and its subscales contribute to higher levels of emotional divorce among this population. Additionally, relationship concern was the lowest concern in infertile people. But it significantly predicts emotional divorce among infertile individuals.