bluuebunny/crossref_metadata_2025_split huggingface dataset:
A two-week exercise intervention improves cold symptoms and sleep condition in cold-sensitive women
Authors: Yamazaki Fumio , Inoue Kana , Ohmi Nanako , Okimoto Chika 
Published: September 2023

Abstract
Background
We examined whether an aerobic exercise intervention in young women with cold sensitivity symptoms improves sleep quality and decreases cold complaints. Furthermore, we examined the association with increased foot skin temperature (Tsk) before falling asleep and decrease in sensitivity to cold in the brain.

Methods
We recruited 16 female adult volunteers who had cold sensitivity and were not engaged in daily exercise training, and they were divided into an exercise group (EXE) and a control group (CON). EXE was given a 2-week exercise intervention that consisted mainly of walking and jogging. Before and after the intervention, temperature sensation and body temperature parameters were measured just before bedtime; electroencephalogram measurements were taken during sleep; and subjective sleep surveys, including Oguri-Shirakawa-Azumi (OSA) sleep inventory (middle-aged and aged version) and visual analogue scale (VAS), were conducted immediately after waking up. All experiments were performed in the winter season.

Results
In EXE, overall and foot warmth and comfort increased (p < 0.05) after the 2-week exercise intervention. The exercise intervention also decreased (p < 0.05) the scores for cold feeling in the fingertips, feet, and toes. In the OSA sleep inventory, factor IV (refreshing) and factor V (sleep length) were increased (p < 0.05) by the exercise intervention. Subjective sleep quality evaluated by VAS increased (p < 0.05) with exercise intervention. The exercise intervention in EXE shortened middle awake time after sleep onset (p < 0.05) and prolonged deep sleep length (p < 0.05). The exercise intervention increased (p < 0.05) alpha-wave power before sleep. In CON, all variables remained unchanged throughout the 2-week control period.

Conclusion
Short-term aerobic exercise alleviated peripheral extremity cold sensitivity symptoms and improved subjective sleep quality. Our findings suggest that these improvements were not due to increased Tsk at rest before bedtime but to decreased sensitivity to cold in the brain that was expressed as increased alpha activity.
A case report assessing the utility of a low-cost tracking GPS device for monitoring terrestrial mammal movements
Authors: Moore Claire , Beaman Julian , Brice Marnie , Burke da Silva Karen 
Published: September 2023

AbstractBackgroundAccurate data on animal movements can highlight behavioural and ecological issues, such as territorial interactions, barriers to migration patterns, including compromised movement corridors, or avoidance of deteriorating habitats, and disease transmission, thus helping in conservation decision making. This study examines the utility of mOOvement global positioning system (GPS) tags, a low-cost cattle ear tag tracking device to monitor movements of terrestrial mammal populations in South Australia.ResultsStationary tags (n = 40) were used to test horizontal accuracy with a median location error of 33.26 m (IQR = 16.9–59.4), and maximum recorded error of 410 m. The locational accuracy was weakly influenced by the horizontal dilution of precision (HDOP), a measure of satellite availability and geometry, and overhead canopy cover. Numerous tags produced infrequent and inconsistent readings, median of 12 records per day (IQR = 6–12), correlating negatively with the tag’s distance from the centrally located LoRa antenna; however, some tags recorded fewer than one position per day.ConclusionsWe propose that the primary cause of mOOvement tag inadequacy is the use of only the GPS satellite constellation (USA, 1978), which does not provide adequate coverage in either satellite number or geometry in the sky at the − 35° latitude to calculate accurate positions regularly over 24 h, unlike the multiple constellations available in the global navigation satellite system (GNSS). We conclude that GPS tags are unsuitable for studies requiring high locational accuracy or identification of an individual’s social interactions, where the GPS constellation has a limited number of satellites available during prolonged periods. They can, however, be used to provide estimates of home range size or track large scale daily movements of animals in more equatorially located regions.
The impact of technology on promoting physical activities and mental health: a gender-based study
Authors: Liu Yangyang , Zhang Hongxue , Xu Ruilin 
Published: September 2023

Abstract
Background
Physical inactivity is a significant public health concern globally, associated with an increased risk of chronic diseases and detrimental effects on both physical and mental health. Technologically based interventions have emerged as a potential solution to promote physical activity engagement and improve mental health outcomes. However, understanding the effectiveness of these interventions and the role of gender in their outcomes is essential for developing tailored strategies.

Objective
This study aims to examine the effectiveness of technologically based interventions in promoting physical activity and improving mental health outcomes, with a specific focus on gender differences.

Methodology
This study employed a three-phase mixed methods research design. Phase one was an experimental phase where 300 participants were randomly assigned to intervention or control groups. The intervention group received a technologically based physical activity intervention, while the control group did not. Physical activity levels and mental health outcomes were assessed before and after the intervention. Phase two involved qualitative interviews with a subset of participants (n = 20) from the intervention group. These interviews explored motivations and barriers to physical activity, aiming to uncover personal factors influencing engagement. Thematic analysis was used to identify recurring themes. Phase three utilized a quantitative survey to compare motivations and barriers between males and females. The survey, administered to a larger sample, included participants from both intervention and control groups. It assessed various factors and allowed for a quantitative comparison of gender differences.

Findings
findings indicated that the intervention improved the mental health and physical activities level of the intervention groups. Findings also there are 8 motivations for and barriers to using technology in physical activities. Male and females’ scores on some of the motivations and barriers were statistically significant.

Conclusion
technology plays an important role in improving the mental health and physical activities of adults. Findings can be used by health care centers, digital psychologists, and physical trainers.
Co-creation of a patient engagement strategy in cancer research funding
Authors: Taccone Michael S. , Baudais Nathalie , Wood Don , Bays Suzanne , Frost Sasha , Urquhart Robin , Graham Ian D. , Takacs Judit 
Published: September 2023

Abstract
Background
As research teams, networks, and institutes, and health, medical, and scientific communities begin to build consensus on the benefits of patient engagement in cancer research, research funders are increasingly looking to meaningfully incorporate patient partnership within funding processes and research requirements. The Canadian Cancer Society (CCS), the largest non-profit cancer research funder in Canada, set out to co-create a patient engagement in cancer research strategy with patients, survivors, caregivers and researchers. The goal of this strategy was to meaningfully and systematically engage with patients in research funding and research activities.

Methods
A team of four patient partners with diverse cancer and personal experiences, and two researchers at different career stages agreed to participate as members of the strategy team. Ten staff members participated in supportive roles and to give context regarding different departments of CCS. The strategy was co-developed in 2021/2022 over a series of 7 workshops using facilitation strategies such as ground rules and consensus building, and methods such as Design Thinking. The strategy was subjected to 3 rounds of validation.

Results
The co-creation and validation process resulted in a multi-faceted strategy with actionable sections, including vision, guiding principles, engagement methods, 13 prioritized engagement activities spanning the spectrum of research funding, and an evaluation framework. The experience of co-creating the strategy was captured using the Patient and Public Engagement Evaluation Tool and revealed a positive, supportive experience.

Conclusions
Lessons learned included the value of an emphasis on a co-creation process from day one, the utility of facilitation techniques such as ground rules for dialogue, consensus building and Design Thinking, and the importance (and challenge) of designing for and incorporating equity when drafting the strategy. Future work will include implementation and evaluation of the strategy, as well as an examination of further ways to meaningfully and systematically engage diverse voices in research and research funding.
Modeling the seismic wavefield of moving marine vibrator source
Authors: Almuteri Khalid , Shragge Jeffrey , Sava Paul 
Published: September 2023

Marine vibrators are an emerging alternative to conventional air guns in ocean-bottom acquisition due to their ability to generate low-frequency waves and limited adverse impact on marine wildlife. However, using marine vibrators introduces challenges not found in conventional air-gun-based acquisition where receivers are placed on the ocean bottom, including handling the phenomena associated with the Doppler effect and time-dependent source-receiver offsets due to the source motion. Standard seismic data processing solutions assume stationary sources and receivers for the duration of any seismic experiment (e.g., a shot); however, accurately accounting for source motion effects in processing is critical for optimal subsurface imaging. To address these challenges, we develop a finite-difference approach for modeling the full acoustic wavefield in a generalized coordinate system that tracks a moving source. Synthetic examples demonstrate that this technique accurately and stably models high-velocity moving sources and accurately accounts for the wavefield distortion predicted by the Doppler effect. This approach is not limited to modeling wavefield propagation for a moving source and can be used to develop advanced imaging and inversion techniques (e.g., reverse time migration and full waveform inversion) for data acquired using marine vibrators. In addition, the developed approach is not only limited to modeling mobile sources but also can model conventional towed-streamer data.
Systemic Therapy for Tumor Control in Metastatic Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline
Authors: Del Rivero Jaydira , Perez Kimberly , Kennedy Erin B. , Mittra Erik S. , Vijayvergia Namrata , Arshad Junaid , Basu Sandip , Chauhan Aman , Dasari Arvind N. , Bellizzi Andrew M. , Gangi Alexandra , Grady Erin , Howe James R. , Ivanidze Jana , Lewis Mark , Mailman Josh , Raj Nitya , Soares Heloisa P. , Soulen Michael C. , White Sarah B. , Chan Jennifer A. , Kunz Pamela L. , Singh Simron , Halfdanarson Thorvardur R. , Strosberg Jonathan R. , Bergsland Emily K. 
Published: September 2023

PURPOSE To develop recommendations for systemic therapy for well-differentiated grade 1 (G1) to grade 3 (G3) metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs). METHODS ASCO convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice. RESULTS Eight randomized controlled trials met the inclusion criteria for the systematic review. RECOMMENDATIONS Somatostatin analogs (SSAs) are recommended as first-line systemic therapy for most patients with G1-grade 2 (G2) metastatic well-differentiated GI-NETs. Observation is an option for patients with low-volume or slow-growing disease without symptoms. After progression on SSAs, peptide receptor radionuclide therapy (PRRT) is recommended as systematic therapy for patients with somatostatin receptor (SSTR)–positive tumors. Everolimus is an alternative second-line therapy, particularly in nonfunctioning NETs and patients with SSTR-negative tumors. SSAs are standard first-line therapy for SSTR-positive pancreatic (pan)NETs. Rarely, observation may be appropriate for asymptomatic patients until progression. Second-line systemic options for panNETs include PRRT (for SSTR-positive tumors), cytotoxic chemotherapy, everolimus, or sunitinib. For SSTR-negative tumors, first-line therapy options are chemotherapy, everolimus, or sunitinib. There are insufficient data to recommend particular sequencing of therapies. Patients with G1-G2 high-volume disease, relatively high Ki-67 index, and/or symptoms related to tumor growth may benefit from early cytotoxic chemotherapy. For G3 GEP-NETs, systemic options for G1-G2 may be considered, although cytotoxic chemotherapy is likely the most effective option for patients with tumor-related symptoms, and SSAs are relatively ineffective. Qualifying statements are provided to assist with treatment choice. Multidisciplinary team management is recommended, along with shared decision making with patients, incorporating their values and preferences, potential benefits and harms, and other characteristics and circumstances, such as comorbidities, performance status, geographic location, and access to care. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines .
Understanding Barriers and Facilitators to High-Quality Cancer Care Among Veterans With Lung Cancer: A Qualitative Study
Authors: Lopez Christopher , Murillo Ariana , Das Millie , Patel Manali I. 
Published: September 2023

PURPOSE Veteran populations have higher lung cancer incidence and worse overall survival compared with non-Veteran populations. Although recent clinical advancements have reduced lung cancer death rates, these advances are not routinely received among Veteran populations because of multilevel factors, including Veterans' complex comorbidities, limited health literacy, and other economic and social disadvantages. This study aimed to assess Veterans' perspectives regarding their lung cancer care with a specific focus on identifying modifiable barriers to evidence-based care delivery. METHODS We conducted 1:1 semistructured interviews with 24 Veterans diagnosed with lung cancer at the Veterans Affairs Palo Alto Health Care System. All interviews were recorded, transcribed, and analyzed using the constant comparative method of qualitative analysis. RESULTS Four themes emerged. These included (1) social and economic disadvantages can prevent routine delivery of evidence-based cancer care; (2) fragmented care contributes to worsening patient mental and emotional well-being; (3) lack of health system interventions to address limited health literacy inhibits patient engagement in shared decision making regarding diagnosis, genomic and molecular testing, targeted and other treatments, and end-of-life care; and (4) deep appreciation for care and VA trustworthiness facilitates adherence to cancer care recommendations. CONCLUSION This study revealed critical gaps in lung cancer care delivery and the role of institution-engendered trust in overcoming barriers in the VA system. Targeted solutions should address the identified barriers to routine, evidence-based lung cancer care delivery among Veterans.
Topological features of Bloch impedance
Authors: Tsukerman Igor , Markel Vadim A. 
Published: September 2023

Abstract
The bulk-boundary correspondence (b-bc) principle states that the presence and number of evanescent bandgap modes at an interface between two periodic media depend on the topological invariants (Chern numbers in 2D or Zak phases in 1D) of propagating modes at completely different frequencies in all Bloch bands below that bandgap. The objective of this letter is to explain, on physical grounds, this connection between modes with completely different characteristics. We assume periodic lossless 1D structures and lattice cells with mirror symmetry; in this case the Zak phase is unambiguously defined. The letter presents a systematic study of the behavior of electromagnetic Bloch impedance, defined as the ratio of electrical and magnetic fields in a Bloch wave at the boundary of a lattice cell. The impedance-centric view confers transparent physical meaning on the bulk-boundary correspondence principle. Borrowing from the semiconductor terminology, we classify the bandgaps as p- and n-type at the Γ and X points, depending on whether the Bloch impedance has a pole (p) or a null (n) at the bottom of that gap. An interface mode exists only for pn-junctions per our definition. We expect these ideas to be extendable to problems in higher dimensions, with a variety of emerging applications.
Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations
Authors: Ali Zeinab , Godoy-Corchuelo Juan M. , Martins-Bach Aurea B. , Garcia-Toledo Irene , Fernández-Beltrán Luis C. , Nair Remya R. , Spring Shoshana , Nieman Brian J. , Jimenez-Coca Irene , Bains Rasneer S. , Forrest Hamish , Lerch Jason P. , Miller Karla L. , Fisher Elizabeth M. C. , Cunningham Thomas J. , Corrochano Silvia 
Published: September 2023

ABSTRACT
Variants in the ubiquitously expressed DNA/RNA-binding protein FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS). Most FUS mutation studies have focused on motor neuron degeneration; little is known about wider systemic or developmental effects. We studied pleiotropic phenotypes in a physiological knock-in mouse model carrying the pathogenic FUSDelta14 mutation in homozygosity. RNA sequencing of multiple organs aimed to identify pathways altered by the mutant protein in the systemic transcriptome, including metabolic tissues, given the link between ALS-frontotemporal dementia and altered metabolism. Few genes were commonly altered across all tissues, and most genes and pathways affected were generally tissue specific. Phenotypic assessment of mice revealed systemic metabolic alterations related to the pathway changes identified. Magnetic resonance imaging brain scans and histological characterisation revealed that homozygous FUSDelta14 brains were smaller than heterozygous and wild-type brains and displayed significant morphological alterations, including a thinner cortex, reduced neuronal number and increased gliosis, which correlated with early cognitive impairment and fatal seizures. These findings show that the disease aetiology of FUS variants can include both neurodevelopmental and systemic alterations.
Estimation of the Compositional Proportions of Different Micelle Species in Water: Application of One-dimensional Aggregate Theory to Small Angle Neutron Scattering Analyzed Data
Authors: Okabayashi Hiro-Fumi , Sasuga-Araki Sonoko , Izawa Ken-Ichi , O’Connor Charmian J 
Published: September 2023

Abstract
The one-dimensional aggregation theory was applied to the small angle neutron scattering (SANS) analyzed data of surfactant solutions. Plots of the hydrophobic bonding energy E to form an aggregate against the number-average aggregation number n were found to be powerful to estimate the compositional ratios of different aggregate species co-existing in a gross sample solution.
Association between clinical manifestations of occlusal trauma and magnetic resonance imaging findings of periodontal ligament space
Authors: Dewake Nanae , Miki Manabu , Ishioka Yasuaki , Nakamura Suguru , Taguchi Akira , Yoshinari Nobuo 
Published: September 2023

Objectives:
The purpose of this study was to evaluate the association between clinical manifestations of occlusal trauma of the teeth and maximum signal intensity of periodontal ligament space on MRI.

Methods:
20 subjects (males: 9, females: 11, mean age: 35.9 ± 14.0 years, range: 22–65 years) participated in this study. Subjective symptoms of bruxism, tooth mobility, fremitus, occlusal contact area, occlusal force, widening of the periodontal ligament space, and thickening of the lamina dura were defined as clinical manifestations of occlusal trauma. The total number of clinical manifestations was used to evaluate the degree of clinical occlusal trauma, with a score of 7 indicating the highest degree of occlusal trauma. The maximum signal intensity in the periodontal ligament space was evaluated by a specific T 2 weighted MRI sequence: IDEAL image.

Results:
Spearman’s rank correlation between the total clinical occlusal trauma score and maximum signal intensity in the periodontal ligament space was 0.529 for all teeth, 0.517 for anterior teeth, and 0.396 for molar teeth (p &lt; 0.001 for all).

Conclusions:
A significant correlation between the degree of occlusal trauma and the signal intensity of the periodontal ligament space suggests a new potential MRI-based method for objectively determining occlusal trauma.
Reporting of angiographic studies in patients diagnosed with a cerebral arteriovenous malformation: a systematic review
Authors: Das Suparna , Kasher Paul , Waqar Mueez , Parry-Jones Adrian , Patel Hiren 
Published: September 2023

A cerebral arteriovenous malformation (cAVM) is an abnormal tangle of cerebral blood vessels. The consensus document by the Joint Writing Group (JWG) highlighted which cAVM features should be recorded. Subsequent publications have reported cAVM angioarchitecture, but it is unknown if all followed the JWG recommendations. The aim of this systematic review was to describe use of the JWG guidelines. A database search, using the PRISMA checklist, was performed. We describe the proportion of publications that used JWG reporting standards, which standards were used, whether the definitions used differed from the JWG, or if any additional angiographic features were reported. Out of 4306 articles identified, 105 were selected, and a further 114 from other sources. Thirty-three studies (33/219; 15%) specifically referred to using JWG standards. Since the JWG publication, few studies have used their standards to report cAVMs. This implies that the angioarchitecture of cAVMs are not routinely fully described.