bluuebunny/crossref_metadata_2025_split huggingface dataset:
-CONNECTEDNESS OF MODULI OF VECTOR BUNDLES ON A CURVE
Authors: Hogadi Amit , Yadav Suraj 
Published: March 2023

AbstractIn this note, we prove that the moduli stack of vector bundles on a curve with a fixed determinant is
${\mathbb A}^1$
-connected. We obtain this result by classifying vector bundles on a curve up to
${\mathbb A}^1$
-concordance. Consequently, we classify
${\mathbb P}^n$
-bundles on a curve up to
${\mathbb A}^1$
-weak equivalence, extending a result in [3] of Asok-Morel. We also give an explicit example of a variety which is
${\mathbb A}^1$
-h-cobordant to a projective bundle over
${\mathbb P}^2$
but does not have the structure of a projective bundle over
${\mathbb P}^2$
, thus answering a question of Asok-Kebekus-Wendt [2].
RF linearity trade-offs for varying T-gate geometries of GaN HEMTs on Si
Authors: ElKashlan Rana , Khaled Ahmad , Rodriguez Raul , Sibaja-Hernandez Arturo , Peralagu Uthayasankaran , Alian AliReza , Collaert Nadine , Wambacq Piet , Parvais Bertrand 
Published: March 2023

AbstractShort-channel Gallium Nitride (GaN) high-electron-mobility transistors (HEMTs) often utilize T-shape gates due to their large gate-line cross-sectional area and subsequent fMAX increase. In this paper, we report the linearity trade-offs associated with varying the T-gate geometries of AlGaN/GaN HEMTs on Si, specifically the gate extensions which serve as field plates and their impact on the large-signal performance. Small-signal characterization and modeling, in addition to TCAD, provide initial guidelines for the optimal dimensions for the gate field plates using the ratio of fT and the product of the gate resistance and the gate-to-drain capacitance. We utilize various characterization methods, including 6 GHz non-linear vector network analyzer characterization in addition to load-pull, to quantify the amplitude and phase distortion and their subsequent impact on the large-signal metrics of the devices under differing matching conditions and bias points. We deduce that the influence of the gate field plates on the amplitude and phase distortion is non-negligible, particularly under matched conditions.
Hyper beamforming with single-sideband time-modulated phased arrays for automotive radar
Authors: Ma Yue , Miao Chen , Wu Wen 
Published: March 2023

AbstractIn this study, a single-sideband time-modulated phased array (STMPA)-based hyper beamforming (HBF) system for automobile radar is suggested. The left beam and the right beam are generated once the improved STMPA is split into two subarrays. The HBF method is then used to produce the hyper beam. The switching sequence may be adjusted to generate the hyper beam in the desired direction. This study's benefits may be summed up as follows: (1) The hyper beam's sidelobe level is lower and its beamwidth is narrower than the conventional beam, which can help with estimating the direction of arrival. (2) The HBF can be achieved over a very wide scanning range. (3) With time as an additional controllable variable, the system's control mode is flexible and only two channels are needed, which lowers the system's cost and complexity. The effectiveness of the algorithm is tested through simulation, and the results highlight the system's potential when used with automobile radar.
Associations between maternal folate status and choline intake during pregnancy and neurodevelopment at 3–4 years of age in the Alberta Pregnancy Outcomes and Nutrition (APrON) study
Authors: Irvine Nathalie , England-Mason Gillian , Field Catherine J. , Letourneau Nicole , Bell Rhonda C. , Giesbrecht Gerald F. , Kinniburgh David W. , MacDonald Amy M. , Martin Jonathan W. , Dewey Deborah ,   APrON Study Team
Published: March 2023

AbstractFolate and choline are methyl donor nutrients that may play a role in fetal brain development. Animal studies have reported that prenatal folate and choline supplementation are associated with better cognitive outcomes in offspring and that these nutrients may interact and affect brain development. Human studies that have investigated associations between maternal prenatal folate or choline levels and neurodevelopmental outcomes have reported contradictory findings and no human studies have examined the potential interactive effect of folate and choline on children’s neurodevelopment. During the second trimester of pregnancy, maternal red blood cell folate was measured from blood samples and choline intake was estimated using a 24-h dietary recall in 309 women in the APrON cohort. At 3–5 years of age, their children’s neurodevelopment was assessed using the Wechsler Preschool and Primary Scales of Intelligence – Fourth EditionCND, NEPSY-II language and memory subtests, four behavioral executive function tasks, and the Movement Assessment Battery for Children – Second Edition. Adjusted regressions revealed no associations between maternal folate and choline levels during pregnancy and most of the child outcomes. On the Dimensional Change Card Sort, an executive function task, there was an interaction effect; at high levels of choline intake (i.e., 1 SD above the mean; 223.03 mg/day), higher maternal folate status was associated with decreased odds of receiving a passing score (β = −0.44; 95%CI −0.81, −0.06). In conclusion, maternal folate status and choline intake during the second trimester of pregnancy were not associated with children’s intelligence, language, memory, or motor outcomes at 3–4 years of age; however, their interaction may have an influence children’s executive functions.
Small molecule metabolites: discovery of biomarkers and therapeutic targets
Authors: Qiu Shi , Cai Ying , Yao Hong , Lin Chunsheng , Xie Yiqiang , Tang Songqi , Zhang Aihua 
Published: March 2023

AbstractMetabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.
Statistical performance indicators and index—a new tool to measure country statistical capacity
Authors: Dang Hai-Anh H. , Pullinger John , Serajuddin Umar , Stacy Brian 
Published: March 2023

AbstractStrong statistical capacity is a prerequisite for producing reliable statistics that helps monitor a country’s governance and economic performance. This is particularly relevant for a large number of poorer countries, which have weaker statistical capacity but have to rely more on these statistics for various objectives such as monitoring poverty reduction or reporting to international donors. We present the Statistical Performance Indicators and Index (SPI) as the World Bank’s new official tool to measure country statistical capacity. The SPI is conceptually motivated, builds on a mathematical foundation, and significantly expands the number of indicators and the number of covered countries compared to its predecessor. The new index has a strong correlation with other common development indicators such as GDP per capita, governance, human capital, poverty, and inequality. It can also accommodate future improvements as the global data landscape evolves.
Diseased and healthy murine local lung strains evaluated using digital image correlation
Authors: Nelson T. M. , Quiros K. A. M. , Dominguez E. C. , Ulu A. , Nordgren T. M. , Eskandari M. 
Published: March 2023

AbstractTissue remodeling in pulmonary disease irreversibly alters lung functionality and impacts quality of life. Mechanical ventilation is amongst the few pulmonary interventions to aid respiration, but can be harmful or fatal, inducing excessive regional (i.e., local) lung strains. Previous studies have advanced understanding of diseased global-level lung response under ventilation, but do not adequately capture the critical local-level response. Here, we pair a custom-designed pressure–volume ventilator with new applications of digital image correlation, to directly assess regional strains in the fibrosis-induced ex-vivo mouse lung, analyzed via regions of interest. We discuss differences between diseased and healthy lung mechanics, such as distensibility, heterogeneity, anisotropy, alveolar recruitment, and rate dependencies. Notably, we compare local and global compliance between diseased and healthy states by assessing the evolution of pressure-strain and pressure–volume curves resulting from various ventilation volumes and rates. We find fibrotic lungs are less-distensible, with altered recruitment behaviors and regional strains, and exhibit disparate behaviors between local and global compliance. Moreover, these diseased characteristics show volume-dependence and rate trends. Ultimately, we demonstrate how fibrotic lungs may be particularly susceptible to damage when contrasted to the strain patterns of healthy counterparts, helping to advance understanding of how ventilator induced lung injury develops.
Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice
Authors: Chou Ming-Yi , Cao Xuhui , Hou Kuan-Chu , Tsai Meng-Han , Lee Chih-Yu , Kuo Meng-Fai , Wu Vin-Cent , Huang Hsin-Yi , Akbarian Schahram , Chang Sheng-Kai , Hu Chung-Yi , Lin Shu-Wha , Huang Hsien-Sung 
Published: March 2023

AbstractGenomic imprinting predominantly occurs in the placenta and brain. Few imprinted microRNAs have been identified in the brain, and their functional roles in the brain are not clear. Here we show paternal, but not maternal, expression of MIR125B2 in human but not mouse brain. Moreover, Mir125b-2m−/p− mice showed impaired learning and memory, and anxiety, whose functions were hippocampus-dependent. Hippocampal granule cells from Mir125b-2m−/p− mice displayed increased neuronal excitability, increased excitatory synaptic transmission, and decreased inhibitory synaptic transmission. Glutamate ionotropic receptor NMDA type subunit 2A (Grin2a), a key regulator of synaptic plasticity, was physically bound by miR-125b-2 and upregulated in the hippocampus of Mir125b-2m−/p− mice. Taken together, our findings demonstrate MIR125B2 imprinted in human but not mouse brain, mediated learning, memory, and anxiety, regulated excitability and synaptic transmission in hippocampal granule cells, and affected hippocampal expression of Grin2a. Our work provides functional mechanisms of a species-specific imprinted microRNA in the brain.
Rickettsial DNA and a trans-splicing rRNA group I intron in the unorthodox mitogenome of the fern Haplopteris ensiformis
Authors: Zumkeller Simon , Polsakiewicz Monika , Knoop Volker 
Published: March 2023

AbstractPlant mitochondrial genomes can be complex owing to highly recombinant structures, lack of gene syntenies, heavy RNA editing and invasion of chloroplast, nuclear or even foreign DNA by horizontal gene transfer (HGT). Leptosporangiate ferns remained the last major plant clade without an assembled mitogenome, likely owing to a demanding combination of the above. We here present both organelle genomes now for Haplopteris ensiformis. More than 1,400 events of C-to-U RNA editing and over 500 events of reverse U-to-C edits affect its organelle transcriptomes. The Haplopteris mtDNA is gene-rich, lacking only the ccm gene suite present in ancestral land plant mitogenomes, but is highly unorthodox, indicating extraordinary recombinogenic activity. Although eleven group II introns known in disrupted trans-splicing states in seed plants exist in conventional cis-arrangements, a particularly complex structure is found for the mitochondrial rrnL gene, which is split into two parts needing reassembly on RNA level by a trans-splicing group I intron. Aside from ca. 80 chloroplast DNA inserts that complicated the mitogenome assembly, the Haplopteris mtDNA features as an idiosyncrasy 30 variably degenerated protein coding regions from Rickettiales bacteria indicative of heavy bacterial HGT on top of tRNA genes of chlamydial origin.
Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms
Authors: Taghi Khani Adeleh , Kumar Anil , Sanchez Ortiz Ashly , Radecki Kelly C. , Aramburo Soraya , Lee Sung June , Hu Zunsong , Damirchi Behzad , Lorenson Mary Y. , Wu Xiwei , Gu Zhaohui , Stohl William , Sanz Ignacio , Meffre Eric , Müschen Markus , Forman Stephen J. , Koff Jean L. , Walker Ameae M. , Swaminathan Srividya 
Published: March 2023

AbstractProlactin (PRL) is elevated in B-cell-mediated lymphoproliferative diseases and promotes B-cell survival. Whether PRL or PRL receptors drive the evolution of B-cell malignancies is unknown. We measure changes in B cells after knocking down the pro-proliferative, anti-apoptotic long isoform of the PRL receptor (LFPRLR) in vivo in systemic lupus erythematosus (SLE)- and B-cell lymphoma-prone mouse models, and the long plus intermediate isoforms (LF/IFPRLR) in human B-cell malignancies. To knockdown LF/IFPRLRs without suppressing expression of the counteractive short PRLR isoforms (SFPRLRs), we employ splice-modulating DNA oligomers. In SLE-prone mice, LFPRLR knockdown reduces numbers and proliferation of pathogenic B-cell subsets and lowers the risk of B-cell transformation by downregulating expression of activation-induced cytidine deaminase. LFPRLR knockdown in lymphoma-prone mice reduces B-cell numbers and their expression of BCL2 and TCL1. In overt human B-cell malignancies, LF/IFPRLR knockdown reduces B-cell viability and their MYC and BCL2 expression. Unlike normal B cells, human B-cell malignancies secrete autocrine PRL and often express no SFPRLRs. Neutralization of secreted PRL reduces the viability of B-cell malignancies. Knockdown of LF/IFPRLR reduces the growth of human B-cell malignancies in vitro and in vivo. Thus, LF/IFPRLR knockdown is a highly specific approach to block the evolution of B-cell neoplasms.
Multi-emission processes of hierarchically structured NaGdF4:Tm:Yb:Tb core@shell nanoparticles
Authors: de Morais Amanda Justino , Bispo-Jr Airton Germano , de Sousa Ferreira Flavia , Mazali Italo Odone , Sigoli Fernando Aparecido 
Published: March 2023

Hierarchically structured-lanthanide-doped β-NaGdF4 nanoparticles emitting by upconversion (UC), downconversion (DC) and/or downshifting (DS) have been investigated for potential applications as anti-counterfeiting agents or in energy conversion.
Optical and near-infrared stellar activity characterization of the early M dwarf Gl 205 with SOPHIE and SPIRou
Authors: Cortés-Zuleta P. , Boisse I. , Klein B. , Martioli E. , Cristofari P. I. , Antoniadis-Karnavas A. , Donati J.-F. , Delfosse X. , Cadieux C. , Heidari N. , Artigau É. , Bellotti S. , Bonfils X. , Carmona A. , Cook N. J. , Díaz R. F. , Doyon R. , Fouqué P. , Moutou C. , Petit P. , Vandal T. , Acuña L. , Arnold L. , Astudillo-Defru N. , Bourrier V. , Bouchy F. , Cloutier R. , Dalal S. , Deleuil M. , Demangeon O. D. S. , Dumusque X. , Forveille T. , Gomes da Silva J. , Hara N. , Hébrard G. , Hoyer S. , Hussain G. , Kiefer F. , Morin J. , Santerne A. , Santos N. C. , Segransan D. , Stalport M. , Udry S. 
Published: March 2023

Context. The stellar activity of M dwarfs is the main limiting factor in the discovery and characterization of the exoplanets orbiting them, because it induces quasi-periodic radial velocity (RV) variations.
Aims. We aim to characterize the magnetic field and stellar activity of the early, moderately active M dwarf Gl 205 in the optical and near-infrared (NIR) domains.
Methods. We obtained high-precision quasi-simultaneous spectra in the optical and NIR with the SOPHIE spectrograph and SPIRou spectropolarimeter between 2019 and 2022. We computed the RVs from both instruments and the SPIRou Stokes V profiles. We used Zeeman–Doppler imaging (ZDI) to map the large-scale magnetic field over the time span of the observations. We studied the temporal behavior of optical and NIR RVs and activity indicators with the Lomb-Scargle periodogram and a quasi-periodic Gaussian process regression (GPR). In the NIR, we studied the equivalent width of Al I, Ti I, K I, Fe I, and He I. We modeled the activity-induced RV jitter using a multi-dimensional GPR with activity indicators as ancillary time series.
Results. The optical and NIR RVs show similar scatter but NIR shows a more complex temporal evolution. We observe an evolution of the magnetic field topology from a poloidal dipolar field in 2019 to a dominantly toroidal field in 2022. We measured a stellar rotation period of Prot = 34.4 ± 0.5 days in the longitudinal magnetic field. Using ZDI, we measure the amount of latitudinal differential rotation (DR) shearing the stellar surface, yielding rotation periods of Peq = 32.0 ± 1.8 days at the stellar equator and Ppol = 45.5 ± 0.3 days at the poles. We observed inconsistencies in the periodicities of the activity indicators that could be explained by these DR values. The multi-dimensional GP modeling yields an RMS of the RV residuals down to the noise level of 3 m s−1 for both instruments while using Hα and the BIS in the optical and the full width at half maximum (FWHM) in the NIR as ancillary time series.
Conclusions. The RV variations observed in Gl 205 are due to stellar activity, with a complex evolution and different expressions in the optical and NIR revealed thanks to an extensive follow-up. Spectropolarimetry remains the best technique to constrain the stellar rotation period over standard activity indicators, particularly for moderately active M dwarfs.
Mining archival data from wide-field astronomical surveys in search of near-Earth objects
Authors: Saifollahi Teymoor , Verdoes Kleijn Gijs , Williams Rees , Micheli Marco , Santana-Ros Toni , Helmich Ewout , Koschny Detlef , Conversi Luca 
Published: March 2023

Context. Increasing our knowledge of the orbits and compositions of near-earth objects (NEOs) is important for a better understanding of the evolution of the Solar System and life. The detection of serendipitous NEO appearances among the millions of archived exposures from large astronomical imaging surveys can provide a contribution which is complementary to NEO surveys.
Aims. Using the ASTROWISE information system, this work aims to assess the detectability rate, the achieved recovery rate and the quality of astrometry when data mining the European Southern Observatory (ESO) archive for the OmegaCAM wide-field imager at the VLT Survey Telescope (VST).
Methods. We developed an automatic pipeline that searches for NEO appearances inside the ASTROWISE environment. Throughout the recovery process the pipeline uses several public web tools (SSOIS, NEODyS, JPL Horizons) to identify possible images that overlap with the positions of NEOs, and acquires information on the NEOs’ predicted position and other properties (e.g. magnitude, rate, and direction of motion) at the time of observations. Considering these properties, the pipeline narrows down the search to potentially detectable NEOs, searches for streak-like objects across the images, and finds a matching streak for the NEOs.
Results. We recovered 196 appearances of NEOs from a set of 968 appearances predicted to be recoverable. It includes appearances for three NEOs that were on the impact risk list at that point. These appearances occurred well before their discovery. The subsequent risk assessment using the extracted astrometry removes these NEOs from the risk list. More generally, we estimate a detectability rate of ~0.05 per NEO at a signal-to-noise ratio higher than 3 for NEOs in the OmegaCAM archive. Our automatic recovery rates are 40% and 20% for NEOs on the risk list and the full list, respectively. The achieved astrometric and photometric accuracy is on average 0.12″ and 0.1 mag.
Conclusions. These results show the high potential of the archival imaging data of the ground-based wide-field surveys as useful instruments for the search, (p)recovery, and characterization of NEOs. Highly automated approaches, as possible using ASTROWISE, make this undertaking feasible.
Teufel mit Engelsflügeln – wenn Vitamin A Leben rettet
Authors: Benoit Tobias Matthieu , Gundermann Stefan 
Published: March 2023

Zusammenfassung
Anamnese und klinischer Befund Ein 40-jähriger, bislang gesunder Patient stellte sich mit neu aufgetretener, hämorrhagischer Diathese auf unserer Notfallstation vor. Klinisch fanden sich ausgeprägte Blutungsstigmata mit großflächigen Ekchymosen im Bereich der Oberschenkel sowie enorale Schleimhauteinblutungen, bei sonst allgemeinem Wohlbefinden.
Untersuchungen Die durchgeführte Gerinnungsdiagnostik war mit dem Bild einer disseminierten intravasalen Verbrauchskoagulopathie vereinbar. Im mikroskopischen Blutbild fand sich zudem eine leukämische Ausschwemmung von 74% morphologisch atypischen Promyelozyten.
Diagnose, Therapie und Verlauf Die in der Folge durchgeführte Knochenmarkdiagnostik stellte die Diagnose einer akuten Promyelozytenleukämie (mikrogranulärer Variante). Neben der Gerinnungsoptimierung wurde noch vor Diagnosebestätigung auf der Notfallstation eine Therapie mit der Vitamin-A-Säure Tretinoin (engl. all-trans retinoic acid, ATRA) eingeleitet, welche im Verlauf um Arsentrioxid (ATO) und das Anthrazyklin Idarubicin ergänzt wurde. Erfreulicherweise zeigte sich ein komplikationsarmer weiterer Verlauf. Der Patient ist zudem hinsichtlich der akuten Promyelozytenleukämie aktuell in kompletter Remission.
Folgerungen Die akute Promyelozytenleukämie macht etwa 10–15% aller akuten myeloischen Leukämien aus, geht initial häufig mit einer ausgeprägten Gerinnungsaktivierung im Sinne einer disseminierten intravasalen Verbrauchskoagulopathie einher und verläuft unbehandelt rasch tödlich. Eine rasche und bereits bei Diagnoseverdacht eingeleitete Therapie mit ATRA, wie auch eine Gerinnungsoptimierung, sind prognostisch entscheidend.