bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of the Chemo/Radioprotective Effects of Melatonin
against Ototoxic Adverse Effects Induced by Chemotherapy and Radiotherapy
Authors: Basirat Usama , Bin  Tariq Umer , Moeen Nawal , Jawhar Zanko Hassan , Shoja Sarah Jawad , Kareem Ali Kamil , Ramírez-Coronel Andrés Alexis , Romero-Parra Rosario Mireya , Zabibah Rahman S. , Gupta Jitendra , Mustafa Yasser Fakri , Farhood Bagher 
Published: May 2023

Background:
Although chemotherapy and radiotherapy are effective in cancer treatment, different
adverse effects induced by these therapeutic modalities (such as ototoxicity) restrict their clinical use. Co-treatment
of melatonin may alleviate the chemotherapy/radiotherapy-induced ototoxicity.

Objective:
In the present study, the otoprotective potentials of melatonin against the ototoxicity induced by chemotherapy
and radiotherapy were reviewed.

Methods:
According to the PRISMA guideline, a systematic search was carried out to identify all relevant
studies on “the role of melatonin against ototoxic damage associated with chemotherapy and radiotherapy” in
the different electronic databases up to September 2022. Sixty-seven articles were screened based on a predefined
set of inclusion and exclusion criteria. Seven eligible studies were finally included in this review.

Results:
The in vitro findings showed that cisplatin chemotherapy significantly decreased the auditory cell viability
compared to the control group; in contrast, the melatonin co-administration increased the cell viability of
cisplatin-treated cells. The results obtained from the distortion product otoacoustic emission (DPOAE) and auditory
brainstem response (ABR) tests demonstrated a decreased amplitude of DPOAE and increased values of
ABR I-IV interval and ABR threshold in mice/rats receiving radiotherapy and cisplatin; nevertheless, melatonin
co-treatment indicated an opposite pattern on these evaluated parameters. It was also found that cisplatin
and radiotherapy could significantly induce the histological and biochemical changes in the auditory cells/tissue.
However, melatonin co-treatment resulted in alleviating the cisplatin/radiotherapy-induced biochemical
and histological changes.

Conclusion:
According to the findings, it was shown that melatonin co-treatment alleviates the ototoxic damage
induced by chemotherapy and radiotherapy. Mechanically, melatonin may exert its otoprotective effects via
its anti-oxidant, anti-apoptotic, and anti-inflammatory activities and other mechanisms.
Biosynthesis of Zinc Oxide Nanoparticles by Lactobacillus spp. and
Investigation of their Antimicrobial Effect
Authors: Sharifabady Saeideh Morovaty , Shakib Pegah , Omidi Behin , Zolfaghari Mohammad Reza 
Published: May 2023

Background:
Nanoparticle biology is preferable to other common methods due to its
economic efficiency and compatibility with the environment. On the other hand, the prevalence of
drug-resistant bacterial strains is expanding and it is necessary to use alternative antibiotic compounds
to deal with them. The aim of the present study was the biosynthesis of zinc oxide nanoparticles(ZnO
NPs) by Lactobacillus spp. and their antimicrobial effect.

Methods:
In this study, after the biosynthesis of ZnO NPs by Lactobacillus spp, Characterization of
Nanoparticulation Was performed by UV–Vis, XRD, and Scanning Electron Microscopy (SEM). Additionally,
Lactobacillus spp. - ZnO NPs were assessed for their antimicrobial properties.

Results:
UV-visible spectroscopy confirmed the Lactobacillus spp. - ZnO NPs absorbed UV in the
region of 300-400 nm. XRD analysis showed the presence of zinc metal in nanoparticles. SEM
revealed that Lactobacillus plantarum - ZnO NPs were smaller than the others. Staphylococcus aureus
showed the largest non-growth halo diameter against ZnO NPs synthesized by L. plantarum ATCC
8014 (3.7 mm). E. coli had the largest growth halo diameter against ZnO NPs synthesized by L. casei
(3 mm) and L. plantarum (2.9 mm). The MIC values of ZnO NPs synthesized by L. plantarum ATCC
8014, L.casei ATCC 39392, L. fermenyum ATCC 9338, L. acidophilus ATCC 4356 were 2,8,8 and 4
μg/mL for Staphylococcus aureus. The MIC values of ZnO NPs synthesized by L. plantarum ATCC
8014, L. casei ATCC 39392, L. fermenyum ATCC 9338, L. acidophilus ATCC 4356 were 2, 4, 4, and
4 μg/ml for E. coli. The lowest MICs were 2 μg/ml for E. coli and S. aureus related to ZnO NPs
synthesized by L. plantarum ATCC 8014. MIC and MBC values were equivalent to each other.

Conclusion:
The results of this research show that ZnO NPs synthesized by L. plantarum ATCC 8014
have more antimicrobial effects than other ZnO NPs used. Therefore, the ZnO NPs made with Lactobacillus
plantarum ATCC 8014 have the potential to kill bacteria and can be considered a candidate
for antibiotic replacement.
Triazole-linked Nucleic Acids: Synthesis, Therapeutics and Synthetic
Biology Applications
Authors: Sharma Vivek K. , Mangla Priyanka , Singh Sunil K. , Prasad Ashok K. 
Published: May 2023

Abstract:
This article covers the triazole-linked nucleic acids where the triazole linkage (TL) replaces the natural phosphate backbone. The replacement is done at either a few selected linkages or all the phosphate linkages. Two triazole linkages, the four-atom TL1 and the six-atom TL2, have been discussed in detail. These triazole-modified oligonucleotides have found a wide range of applications, from therapeutics to synthetic biology. For example, the triazole-linked oligonucleotides have been used in the antisense oligonucleotide (ASO), small interfering RNA (siRNA) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology as therapeutic agents. Due to the ease of the synthesis and a wide range of biocompatibility, the triazole linkage TL2 has been used to assemble a functional 300-mer DNA from alkyne- and azide-functionalized 100-mer oligonucleotides as well as an epigenetically modified variant of a 335 base-pair gene from ten short oligonucleotides. These outcomes highlight the potential of triazole-linked nucleic acids and open the doors for other TL designs and artificial backbones to fully exploit the vast potential of artificial nucleic acids in therapeutics, synthetic biology and biotechnology.
An Insight into the Pathogenesis of Diabetic Cardiomyopathy Along with
the Novel Potential Therapeutic Approaches
Authors: Vig Himangi , AP Ravinandan , Vishwas Hunsur Nagendra , Tyagi Sachin , Rathore Shruti , Wal Ankita , Wal Pranay 
Published: May 2023

Background:
The existence of aberrant myocardial activity and function in the exclusion
of those other cardiovascular events, such as atherosclerosis, hypertension, and severe valve
disease, is known as diabetic cardiomyopathy. Diabetes patients are much more prone to death
from cardiovascular illnesses than from any other cause, and they also have a 2–5 fold higher likelihood
of acquiring cardiac failure and other complications.

Objective:
In this review, the pathophysiology of diabetic cardiomyopathy is discussed, with an
emphasis on the molecular and cellular irregularities that arise as the condition progresses, as well
as existing and prospective future treatments.

Method:
The literature for this topic was researched utilizing Google Scholar as a search engine.
Before compiling the review article, several research and review publications from various publishers,
including Bentham Science, Nature, Frontiers, and Elsevier, were investigated.

Result:
The abnormal cardiac remodelling, marked by left ventricular concentric thickening and
interstitial fibrosis contributing to diastolic impairment, is mediated by hyperglycemia, and insulin
sensitivity. The pathophysiology of diabetic cardiomyopathy has been linked to altered biochemical
parameters, decreased calcium regulation and energy production, enhanced oxidative damage
and inflammation, and a build-up of advanced glycation end products.

Conclusion:
Antihyperglycemic medications are essential for managing diabetes because they successfully
lower microvascular problems. GLP-1 receptor agonists and sodium-glucose cotransporter
2 inhibitors have now been proven to benefit heart health by having a direct impact on the
cardiomyocyte. To cure and avoid diabetic cardiomyopathy new medicines are being researched,
including miRNA and stem cell therapies.
Parenteral vs Enteral Nutrition: A Retrospective Study on PNI and Inflammatory Status
Authors: Merra Giuseppe , Donati Giulia , Romano Lorenzo , Gualtieri Paola , Capacci Annunziata , Di Renzo Laura , De Lorenzo Antonino 
Published: May 2023

Background:
Malnutrition consists of a functional and structural alteration caused by
an imbalance between specific needs, intake, or utilization of foods and nutrients.

Objective:
The aim of this trial is to establish whether PNI (Prognostic Nutritional Index) is related
to the inflammation pattern in our patients and which type of AN gives more advantages in
clinical practice in improving PNI, and so the prognosis.

Methods:
During hospitalization, we have identified the presence of malnutrition and its aetiology-
type, and initiated artificial nutrition (AN), enteral (EN), or parenteral (PN). For efficacy, we
can use many biochemical tests, such as pre-albumin, transferrin, RBP, PINI, and albumin. The
retrospective study was conducted by analyzing 145 patients. At baseline and after 7 days, the
concentration of Albumin, Platelets, Neutrophils, Lymphocytes, and RCP was measured and was
calculated PNI, PLR, and NLR. The patients were divided into three groups according to the
treatment received with artificial nutrition: 32 Parenteral (PG), 15 Enteral (EG), and 17 Combined
(CG).

Results:
Between baseline and 7 days, no change was observed, while in EG a significant increase
in albumin and RCP and a significant reduction in PNI were observed, and, in CG a significant
increase in lymphocytes, in PNI and a significant reduction in NLR.

Conclusion:
In conclusion, a short-term nutritional intervention can benefit from a combined approach
to improve prognostic such as PNI.
Efficacy of Homoeopathy In PCOS- A Review
Authors: Rath Padmalaya , Sharma Bindu , Gautam Priya , Misra Pankhuri 
Published: May 2023

Introduction:
To evaluate the usefulness of homeopathy for the treatment of PCOS through
a literature review and to develop a strategy for future research.

Method:
A comprehensive search was done in electronic databases, including general medical databases MEDLINE, CENTRAL, Science Direct, specialised database for homeopathy CORE-Hom,
CAM databases LILACS Chiro ACCESS, AYUSH Research Portal, Google Scholar, Research gate
net, clinical trial registry, aimed to target the available literature of observational studies, randomized
trials, controlled trials, case reports on PCOS in homeopathy and limited to the English language. The
inclusion criteria are the studies with a full-text present in mentioned databases, studies with experimental or quasi-experimental designs published in peer-reviewed or partial peer-reviewed journals and
studies with humans as their samples.

Result:
A literary search through databases helped to identify a few significant studies, such as one
placebo-controlled trial, one comparative clinical study, one retrospective study, three clinical studies,
and nine case reports. A retrospective study showed positive results for the role of homeopathic medicines in PCOS. The placebo-controlled trial showed a difference in outcome between the two groups.
The verum group showed a positive effect in the regularization of menses. The comparative clinical
study showed that both homeopathic medicines (Cal. carb, Lycopodium) appeared to be effective.
Three clinical studies showed the effectiveness of homeopathic medicines in improving and curing
PCOS. Nine case reports showed a positive effect of homeopathy in improving PCOS, out of which
three cases showed positive outcomes also in infertility with PCOS.

Conclusion:
The results showed that Homoeopathy has positive effects on the management of PCOS
in women. In the future, high-quality randomized controlled trials (RCT), comparative studies of homeopathy with conventional therapy, and in-vitro and animal model studies will be required to support
the effectiveness of homeopathic therapeutics in PCOS.
Monocomponent Biosorption of Copper Ions (II) onto Nanocrystalline
Cellulose from Coconut Husk Fibers
Authors: Binti Abdullah Nur Athirah , Badiei Marzieh , Mohammad Masita , Asim Nilofar , Yaakob Zahira , Radli Othman Mohd. Amir 
Published: May 2023

Introduction:
Nanocrystalline cellulose (NCC) is one of the most suitable cellulose derivatives
for the treatment of wastewater. Various agricultural wastes have been used for the extraction
of NCC. Coconut wastes have been widely studied as potential adsorbents for the removal
of pollutants, including dyes and heavy metals.

Methods:
In this work, nanocrystalline cellulose (NCC) was successfully isolated from coconut
husk fibers through alkaline pretreatment accompanied by sulfuric acid hydrolysis. Then, the ability
of NCC to adsorb Cu2+ from aqueous solution in batch studies was investigated.

Results:
Results indicated that the optimal hydrolysis parameters were achieved at 50° C for 45
min with 64% sulfuric acid to extract NCC as rod-like particles with diameters between 4-10 nm.
The potential of NCC as a biosorbent to remove copper ions (Cu2+) from aqueous solution was
investigated in terms of batch mode and maximum adsorption capacity (qm) of 79.491 mg/g of
Cu2+. The adsorption efficiency of Cu2+ions increased with an increase in the adsorbent dosage,
decreased with an increase in the initial concentration of contaminant, and increased with the contact
time. Under optimal conditions, adsorption kinetic followed a pseudo-second-order kinetic
model and the adsorption isotherm fitted most closely with the Langmuir model.

Conclusion:
According to a literature review, NCC from coconut husk fibers has not been used for
the adsorption of heavy metals, mainly copper ions. This study shows that NCC from coconut husk
fibers can be used as a low-cost and environmentally friendly adsorbent for the removal of Cu2+
from aqueous solutions.
An Insight into the Combination of Probiotics and their Implications for Human Health
Authors: Hmar El Bethel Lalthavel , Paul Sujata , Sharma Hemanta Kumar 
Published: May 2023

Abstract:
Over 100-1000 microbial species reside in the human gut, where they predominantly in-fluence the host's internal environment and, thus, have a significant impact on host health. Probiotics are best characterized as a microbe or a group of microbes that reside in the gut and support the body's internal microbiota. Probiotics are linked to increased health advantages, including better immune function, improved nutritional absorption, and protection against cancer and heart-related illnesses. Several studies have demonstrated that combining probiotics from different strains with complemen-tary activities may have synergistic advantages and aid in re-establishing the equilibrium of how immunological niches and microorganisms interact. Another thing to remember is that even though a product contains more probiotic strains, that doesn't always guarantee that the health benefits will be more significant. For specific combinations to be justified, there must be clinical proof. The clin-ical results of a probiotic strain are specifically pertinent to the participants in the relevant research, such as studies on adults or newborn infants. Clinical outcomes of a probiotic strain are mainly con-nected to the investigated health area (such as gut health, immune health, oral health, etc.). As a result, picking the right probiotic is essential yet tricky because of several factors, including probiotic products with the disease and strain-specific effectiveness exists; however, various probiotic strains have diverse modes of action. The current review focuses on probiotic categorization, their function in enhancing human health, and any potential health benefits of probiotic combinations.
Technology Prospection of Ora-pro-Nóbis (Pereskia aculeata
Mill.): A Non-conventional Food Plant
Authors: Miranda Sá Kellen , Lima Soares Igor , de Souza Leão Marcos Venânces , Carneiro  Ferreira Maria Izabel , do Nascimento Patrícia Georgina Garcia , Martins Pontes Claudilane , da  Hora Alane Maia , Pontes  Leal Lucas , de Oliveira Maria Nilka , Medeiros  Bandeira Mary Anne , Ferreira  Pontes Dorasilvia 
Published: May 2023

Background::
The ora-pro-nóbis (Pereskia aculeata Mill.) is a plant from Brazilian
biodiversity used for food and medicinal purposes. It has ample technological potential,
however, it is still underutilized, being classified as a Non-Conventional Food Plant (PANC).
Prospective studies in intellectual property banks make it possible to expand perspectives for
scientific research, enhancing the generation of new products.

Objective::
Evaluate the patents of products containing Pereskia aculeata Mill. for the areas
of food and health in intellectual property databases.

Methods::
The study was conducted through structured prospective investigation (collection,
processing and analysis) in 4 patent databases: National Institute of Intellectual Property
(INPI) - Brazil, United States Patent and Trademark Office, World Trade Organization Intellectual
Property (WIPO) and Espacenet.

Results::
The evaluation showed a reduced number of registered patents. In general, 8 patent
applications were examined, of which 7 are directly associated with the species (and its derivatives)
and 1 is related to a device specially designed for harvesting leaves/fruits and removing
thorns. The focus of the patents was the use of the species in the food, pharmaceutical
and biotechnological areas, with emphasis on the use of the leaves in the extraction of
mucilage and proteins.

Conclusion::
This study showed that Pereskia aculeata Mill. is a technologically promising
plant, because of its nutritional and medicinal composition, and it is important to encourage
innovation and the development of new products with the species.
CNN-RNN Algorithm-based Traffic Congestion Prediction System using
Tri-Stage Attention
Authors: Asif S. , Kartheeban K. 
Published: May 2023

Abstract:
Most people consider traffic congestion to be a major issue since it increases noise, pollution, and time wastage. Traffic congestion is caused by dynamic traffic flow, which is a serious concern. The current normal traffic light system is not enough to handle the traffic congestion problems since it functions with a fixed-time length strategy.

Methods::
Despite the massive amount of traffic surveillance videos and images collected in daily monitoring, deep learning techniques for traffic intelligence management and control have been underutilized. Hence, in this paper, we propose a novel traffic congestion prediction system using a deep learning approach. Initially, the traffic data from the sensors is obtained and pre-processed using normalization. The features are extracted using Multi-Linear Discriminant Analysis (M-LDA). We propose Tri-stage Attention-based Convolutional Neural Network- Recurrent Neural Network (TA- CNN-RNN) for predicting traffic congestion.

Results:
To evaluate the effectiveness of the proposed model, the Mean Absolute Error (MAE), Mean Squared Error (MSE), and Root Mean Squared Error (RMSE) were used as the evaluation metrics.

Conclusion:
The experimental trial could extend its successful application to the traffic surveillance system and has the potential to enhancement an intelligent transport system in the future.
Study of Hydrolytic Enzymes Activity and Stability of the Isolated Yeast Close to Zygoascus hellenicus
Authors: Dilmaghani Azita , Elyasi Far Babak , Sajadi Fereydoun , Nazemiyeh Hossein , Mehdizadeh Aghdam Elnaz 
Published: May 2023

Background:
Lipase is one of the most well-known and essential biocatalysts in the de-tergent, food, and pharmaceutical industries. Microbial lipase sources such as yeasts are applicable due to their stability in harsh conditions.

Objective:
In this study, the effect of temperature, initial pH, and incubation time were investigated to improve the extracellular lipase production by yeast, named Zygoascus hellenicus strain MZ_574439 T.

Methods:
Strain MZ_574439 T has already been isolated and registered from Iran. In the current project, strain MZ_574439 T with 99% similarity to Z. hellenicus was isolated from water samples.

Results:
Our findings showed that the isolated strain has a remarkable difference from its close phy-logenetic species in the production of lipase and can produce extracellular lipase up to 7.2 U/ml while the Z. hellenicus has no ability of lipase production. The isolated strain was not able to pro-duce other hydrolytic enzymes. The enzyme activity results showed that the best activity for the iso-lated lipase is pH= 7 and 37°C. The best stability condition for the enzyme occurs at 50°C and pH =7.

Conclusion:
From the current study, it can be concluded that Z. hellenicus produces lipase. The li-pase enzyme production was optimized with different physiological conditions. Yeast extract could be a better source for maximum lipase production.
STUDY OF TEACHING COMPETENCE IN RELATION TO SELF- EFFICACY AMONG SECONDARY SCHOOL TEACHERS
Authors: Kaur Navdeep . , Kaur Harmeet  . 
Published: May 2023

The purpose of the present study is to investigate the relationship between teaching competence and self-efficacy of secondary school teachers. The study also examined the differences in self- efficacy and teaching competence of secondary school teachers with respect to type of school and gender. To conduct the study, 100 respondents from Tarn-Taran city were selected. Two tools were adopted to measure teaching competency and s	elf-efficacy of secondary school teachers. Teacher Efficacy Scale (TES) by Dr. T. Pardeep Kumar (2012), General Teaching Competency Scale (GTCS) by B.K. Passi and Lalitha (2011). The study further revealed that there is significant difference in teaching competence and self-efficacy of government and private secondary school teachers. Female teachers teaching competency and self-efficacy is higher as compared to male teachers. However positive relationship between teaching competence and self -efficacy of secondary school teachers is found.
Post-concussion syndrome and concussion incidence improved in a pro rugby player following cervical spine rehab: case study and 6-year follow-up
Authors: Strauss Seth , Lightstone Douglas F , Fedorchuk Curtis , Pomahac Robert , Oakley Paul A , Harrison Deed E 
Published: May 2023

Aim: To report improvements in post-concussion syndrome and concussion incidence following cervical spinal alignment correction. Case presentation: A 27-year-old professional rugby player with 20 documented concussions presented with abnormal cervical spinal alignment and post-concussion syndrome. After 30 sessions of cervical rehabilitation, health outcomes improved. Post-treatment radiographs showed improved cervical lordosis from -13.5° to -37.4° (ideal is -42°) and right head translation from -22.7 to -11.3 mm (ideal is 0 mm). 2-year follow-up radiographs and 6-year follow-up health outcomes showed post-treatment improvements were maintained. The patient reported two documented concussions in the 6 years following treatment while maintaining the same lifestyle and professional rugby career. Conclusion: Correction of abnormal cervical spinal alignment may help athletes with post-concussion syndrome and reduce risk of concussion.