bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertension and Cardiac Damage in Pheochromocytoma and Paraganglioma Patients: A 598 Single-Center Cohort Study
Authors: Yu Yang , Chen Chuyun , Meng Lei , Han Wencong , Zhang Yan , Zhang Zheng , Yang Ying 
Published: September 2023

Abstract
Background
Hypertension (HT) and cardiac damage are the most common complications in pheochromocytoma and paraganglioma (PPGL). Although cardiovascular manifestations have been concerned in previous studies, the profile of HT and cardiac structure and function alteration in a large cohort of PPGL were rarely reported. In this study, we focused on HT prevalence and left ventricular remodeling (LVR) in a consecutive PPGL cohort.
Materials and methods
Five hundred and ninety-eight consecutive patients who underwent surgery for PPGL in a single center from January 2001 to April 2022 were enrolled. Demographic data, cause of hospitalization, medical history, biochemical examinations, echocardiography results and characteristics of tumors were recorded. And patients were grouped by HT history.
Results
The average age was 47.07 ± 15.07 years and 277 (46.32%) of the patients were male. Out of 598 PPGL patients, 423(70.74%) had HT history. Comparing with non-HT group, HT group had higher rate of ectopic tumor (26.00% vs. 17.71%, P = 0.030) and less likelihood been found incidentally during health examination (22.93% vs. 59.43%, P < 0.001). Left ventricular mass index (LVMI) (86.58 ± 26.70 vs. 75.80 ± 17.26, P < 0.001) and relative wall thickness (RWT) (0.43 ± 0.08 vs. 0.41 ± 0.06, P = 0.012) was larger in PPGL patients with HT history than the patients without HT history. And the proportion of left ventricular hypertrophy (LVH) (19.40% vs. 8.25%, P = 0.011) and LVR (53.73% vs. 39.18%, P = 0.014) was higher in HT history group comparing with the other. After adjusting for age, sex, BMI, drink, smoke, diabetes, stroke, creatinine, ectopic tumor and tumor size, HT history was significantly correlated with LVH (OR:2.71; 95% CI, 1.18—6.19; P = 0.018) and LVR (OR:1.83; 95% CI, 1.11—3.03; P = 0.018).
Conclusion
HT was common (70.74% in this cohort) in PPGL. PPGL without HT history was more likely been found incidentally (59.43% in this cohort). HT was associated with LVR in PPGL patients. Cardiac damage with LVH/LVR should be payed attention in PPGL especially in those with HT.
The epidemiology and the pathogen distribution of pediatric dacryocystitis in Chinese population 2017-2022, a cohort study
Authors: Sun Zhihong , Li Mingchao , Sun Huiqing 
Published: September 2023

Abstract

Background:Analysis of basic information, flora distribution, and characteristics of information on drug-resistant bacteria in children with dacryocystitis for six years, providing evidence for ophthalmologic infection prevention and clinical management strategies.Methods:A retrospective cohort study was conducted to evaluate the demographics of dacryocystitis in children and microbiological characteristics of secretion cultures, and to analyze the basic information, distribution of pathogenic bacteria, drug resistance, and to plot trendsand distribution pie charts according to the yearsResults:This study recruited 5791 specimens. Decreased incidence of dacryocystitis from 2020-2022 (including the Coronavirus disease-19 (COVID-19) pandemic). The age of highest incidence of dacryocystitis is infancy, followed by the neonatal period, and the incidence decreased with age. Streptococcus pneumoniae had the highest percentage in 2017, and the overall trend was decreasing, the difference was statistically significant (p<0.001); Streptococcus mitis showed an overall increasing trend, with the highest incidence in 2022 and the lowest in 2017, with a statistically significant difference (p < 0.001); Haemophilus influenzae was the most common gram-negative bacteria with an overall decreasing trend (p < 0.001); The incidence of Catamoeba and Stenotrophomonas varied from year to year, with statistically significant differences (p = 0.010, p=0.033, respectively). Methicillin-resistant Staphylococcus aureus (MRSA) had the lowest incidence in 2017 and 2022 the highest incidence in 2022, with a statistically significant difference in incidence between years (p=0.003); β-lactamase-positive was the most common type of resistance, and MRSA was the second, with statistically significant differences between years (p=0.003, p<0.001, respectively). Streptococcus pneumoniae is a common etiologic agent of dacryocystitis in all age groups.Conclusions:Dacryocystitis in children is significantly associated with age characteristics and infection-related pathogens, and infection prevention and control can help reduce the infection of related pathogens and the increase of new drug-resistant strains. Close monitoring of changes in pathogen distribution in ocular secretion cultures can help in early intervention and treatment of infectious dacryocystitis.
Optimizing Radiation Emulator Training: Streamlined Hyperparameter Tuning with Automated Sherpa
Authors: Kim Park Sa , Roh Soonyoung , Song Hwan-Jin 
Published: September 2023

Abstract
This study aimed to determine the optimal configuration of neural network emulators for numerical weather prediction with minimized trial and error by comparing the performance of emulators utilizing neurons obtained from multiple hidden layers (1-5 layers) automatically defined by the Sherpa library. Findings revealed that emulators with Sherpa-determined neurons demonstrated good results, stable performance, and low errors in numerical simulations. Optimal configurations manifested in one and two hidden layers, displaying a moderate enhancement with the incorporation of dual hidden layers. The mean neuron quantity per hidden layer, ascertained by Sherpa, spanned from 153 to 440, culminating in a 7-12 fold acceleration augmentation. These insights could guide the development of radiative physical neural network emulators as automatically determined hyperparameters can effectively reduce trial and error processes while maintaining stable outcomes. Further experimentation is recommended to establish the best balance between speed and accuracy, as this study did not identify optimized values for all hyperparameters. Overall, this research highlights the importance of hyperparameter optimization in designing efficient and accurate neural network emulators for weather prediction.
A low-cost and rapid DNA extraction method with surface-modified tungsten needle for citrus Huanglongbing field diagnosis by combining visual LAMP reaction
Authors: Zhao Ruiming , Liu Yuanyuan , Zhang Juan , Chen Ailiang , Gong Yan 
Published: September 2023

Abstract

Time-consuming and complicated DNA/RNA extraction procedure has always been bottleneck for nucleic acid detection in various field, including medical diagnosis, food safety and environmental analysis, especially for plant disease detection which has hard cell walls and exacerbates the nucleic acid extraction difficulty. Furthermore, unlike medical diagnosis with a save-life purpose in a well-equipped central lab, the agricultural nucleic acid assay can’t afford a high price due to low economic benefit and often needs to be done in low-resource fields. So far, no low-cost and rapid nucleic acid-based method is available for plant disease detection in field. To address this problem, a low-cost surface-modified tungsten needle was prepared for rapid DNA extraction from citrus leaf within one minute and a visual loop-mediated isothermal amplification was developed for citrus Huanglongbing detection in field. The tungsten needle costs around only $0.2, the needle tip is only about 1µm in diameter and the DNA extraction efficiency was validated with other kinds of samples as well as commercial DNA extraction kit. The whole citrus diagnosis could be finished within 1 hour and no other complicated types of equipment are needed but a simple portable metal bath. The low-cost, rapid and in-field tungsten needle-based nucleic acid extraction combining visual LAMP detection method could be extended to other plant disease diagnoses.
Anti-prostate cancer mechanism of black ginseng during the "Nine Steaming and Nine Sun-Drying" process based on HPLC analysis combined with vector space network pharmacology
Authors: Zhang Youran , Huang Ye , Dou Deqiang 
Published: September 2023

Abstract
Purpose
The vector space network pharmacology method was established to investigate the anti-prostate cancer mechanism of black ginseng in the process of "nine steaming and nine sun-drying".
Methods
Six small-molecule organic acids, maltol, 5-HMF, 17 ginsenosides, 4 oligosaccharides, and 20 amino acids in black ginseng samples with different processing times were determined by HPLC analysis. Based on the content determination results, the differential ingredients in the processing of black ginseng were screened by multivariate statistical analysis. The core targets and pathways of the above ingredients against prostate cancer were obtained by network pharmacological methods. Finally, the entropy weight method was used to assign values to the above ingredients, targets, and pathways, and the vector space network pharmacology method was established to study the anti-prostate cancer mechanism of black ginseng in the process of "nine steaming and nine sun-drying".
Results
Based on principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), fructose, glucose, dencichin, glutamate, ginsenoside 20 (S)-Rg3, 20 (R)-Rg3, 20 (S)-Rh2, Rg1, Re, and Rc were the main differential ingredients in various steaming and sun-drying cycle periods of black ginseng. The results of vector space network pharmacology showed that the main reason for the change in the anti-prostate cancer pathway of black ginseng with the number of steaming and sun-drying was the different regulatory ability of black ginseng on the PI3K-Akt signaling pathway and chemical carcinogenesis-receptor activation pathway.
Conclusion
The study found that the content of each ingredient in black ginseng changed with the number of steaming and sun-drying cycle periods. It also discovered the anti-prostate cancer pathway through vector space network pharmacology, which gave researchers a fresh perspective for exploring the anti-prostate cancer active components of black ginseng and the mechanism of the effect of traditional Chinese medicine in the process of drug processing.
Dynamic changes of rumen microbiota and serum metabolome revealed increases in meat quality and growth performances of sheep fed bio-fermented rice straw
Authors: Kyawt Yin Yin , Aung Min , Xu Yao , Sun Zhanying , Zhou Yaqi , Zhu Weiyun , Padmakumar Varijakshapanicker , Tan Zhankun , Cheng Yanfen 
Published: September 2023

Abstract
Background Providing high-quality roughage is crucial for the development of ruminant production because it is an essential component of their feed. Our previous study showed that feeding bio-fermented rice straw (BF) improved the feed intake and weight gain of sheep. However, it remains unclear why feeding BF to sheep increased their feed intake and weight gain. Therefore, the purposes of this research were to investigate how the rumen microbiota and serum metabolome are dynamically changing after feeding BF, as well as how their changes influence the feed intake, digestibility, nutrient transport, meat quality and growth performances of sheep. Twelve growing Hu sheep were allocated into three groups; alfalfa hay fed group (AH: positive control), rice straw fed group (RS: negative control) and BF fed group (BF: treatment). Samples of rumen content, blood, rumen epithelium, muscle, feed offered and refusals were collected for the subsequent analysis.Results Feeding BF changed the microbial community and rumen fermentation, particularly increasing (P < 0.05) relative abundance of Prevotella and propionate production, and decreasing (P < 0.05) enteric methane yield. The histomorphology (height, width, area and thickness) of rumen papillae and gene expression for carbohydrate transport (MCT1), tight junction (Claudin-1, Claudin-4), and cell proliferation (CDK4, Cyclin A2, Cyclin E1) were improved (P < 0.05) in sheep fed BF. Additionally, serum metabolome was also dynamically changed, which led to up-regulating (P < 0.05) the primary bile acid biosynthesis and biosynthesis of unsaturated fatty acid in sheep fed BF. As a result, the higher (P < 0.05) feed intake, digestibility, growth rate, feed efficiency, meat quality and mono-unsaturated fatty acid concentration in muscle, and the lower (P < 0.05) feed cost per kg of live weight were achieved by feeding BF.Conclusions Feeding BF improved the growth performances and meat quality of sheep and reduced their feed cost. Therefore, bio-fermentation of rice straw could be an innovative way for improving ruminant production with minimizing production costs.
Seroprevalence of Hepatitis B, Hepatitis C, and HIV in pregnant women attending a tertiary care hospital in Mogadishu, Somalia, 2017-2021
Authors: Hassan-Kadle Mohamed Abdulkadir , Keles Esra , Nor Mosab Ahmed , Hassan Mohamed Abdulahi , Karaketir Şeyma , Hussein Ahmed Isak , Eker Hasan Huseyin 
Published: September 2023

Abstract
Hepatitis B, C, and HIV infections are serious global health concerns, affecting both developed and developing nations. This study reported from Somalia that determines the prevalence of hepatitis B, hepatitis C, and HIV among pregnant women attending a tertiary hospital in Mogadishu, Somalia. Pregnant women with missing variables, who had a history of liver disease, diabetes, and HELLP syndrome were excluded. HBsAg, anti-HCV, and Anti HIV were measured using Enzyme-Linked Immunosorbent Assay in the hospital’s biochemistry laboratory. Over a 5-year period, hepatitis B, C, and HIV infections were requested from 7874 pregnant mothers. 7836 were tested for hepatitis B infection, with 220 (2.8%) having HBsAg positivity. 7791 pregnant women were tested anti-HCV, with 33 (0.4%) having anti-HCV seropositivity and 7854 pregnant women were tested for HIV, with 16 (0.2%) positive. This study shows that the HBV prevalence in pregnant women is 2.8%, which is lower than previous reports. HCV in pregnant women is the first study reported in the country. HIV infection also indicates a high prevalence among pregnant women in Somalia. Antenatal screening for these infections is recommended, as there are critical therapies available for both the mother and newborn.
Study of Palatal Rugae Among the Student Population From North - Eastern and Western India
Authors: Mehta Sheen Singh , Athokpam Tondon Devi , Sharma Swathi , Athokpam Monica , Nandeibam Sanjiv 
Published: September 2023

Abstract
Proposed by Torbo Hermosa in 1932, Palatoscopy is the study of palatal rugae pattern. Rugae patterns are stable and unique to every individual just as his/her finger prints and DNA comparisons. Once formed, they stay robust for the rest of our lives and are resistant to burns, chemicals and decomposition. For challenging forensic identification, as needed in mass disasters, major fire outbreaks and decomposition of bodies where finger print data, DNA matching cannot be made available, rugoscopy can be used as an alternative for human identification especially in situations that lead to teeth loss or involve edentulous persons. Objectives The purpose of this study is to determine the most prominent rugae patterns in terms of shape, number and orientation and delineate if there are any differences in rugae patterns among individuals from eastern and the western regions of India. Rugae patterns being specific to ethnic groups can be used effectively in population identification. Materials and Methods The rugae patterns were assessed by applying Thomas and Kotze classification and Carrea classification for 50 individuals of the same age group. 25 males and females from North Eastern India and 25 males and females from western India respectively. Association between the Rugae patterns were assessed using independent t test and chi square tests. Results. There was a significant difference present in the number of Rugae in the north eastern and western populations with p = > 0.05. The predominant shape was Wavy followed by curved and straight pattern. Conclusions. Rugae pattern may be an adjunctive method of differentiating between the North-eastern and western populations. A larger sample study might be undertaken to validate this claim. Clinical relevance: Palatal rugae are unique like finger prints and are specific to racial groups facilitating population identification especially in edentulous cases. They are resistant, stable and cost-effective forensic parameters for population identification.
Preparation and study of modified phytic acid/epoxy resin anti-corrosion coating
Authors: Ju Jun-Jie , Wang Yang , Yu Ming-Hua , Sun Xin , Li Wei-Li , Zhao Zheng-Bai 
Published: September 2023

Abstract
The anti-corrosion epoxy-based coating is crucial for industrial development. Improvement of the anti-corrosion of epoxy-based coatings through a simple, effective and eco-friendly way is of great significance. Phytic acid (PA) is a kind of natural and eco-friendly corrosion inhibitor, however, the compatibility problem between PA and epoxy resin (EP) is not good. This problem is addressed by the modification of PA in this paper. PA is grafted to ethylene glycol diglycidyl ether (EGDE) to obtain modified PA (PA-EGDE) by the catalysis of tetrabutylammonium bromide under mild conditions. Subsequently, PA-EGDE is added to EP to prepare PA-EGDE/EP coatings. When the PA-EGDE loading is 5 wt%, the PA-EGDE/EP coating exhibits excellent mechanical and anti-corrosion properties. The hardness, flexibility and shock resistance are 2H, 1mm and 50cm, respectively, which are as good as those of pure EP coating. The Ecorr value of PA-EGDE/EP coating at 5 wt% PA-EGDE loading is -0.620 eV, which is much higher than that of EP coating (-0.797 eV); the impedance modulus is 108 Ω·cm2 after immersion in 3.5 wt% NaCl aqueous solution for 30 days, which is much bigger than that of EP coating (106 Ω·cm2). Otherwise, the anti-corrosion mechanism of PA in EP coating is thoroughly discussed.
Evaluation of the anti-AChE and protective effect of New Imidazole Derivatives: In Silico Analysis and Experimental study on oxidative stress and Oligodendrocyte Death
Authors: smach mohamed ali , Hajri Azhar , hafsa jawhar , Abdallah jihène Ben , Charfeddine Bassem , Limem Khalifa 
Published: September 2023

Abstract
Purpose : Neurodegenerative diseases, including Alzheimer disease, are associated with oxidative stress and disruption of cholinergic neurotransmission. Thus the search for molecules capable of modulating ROS production and acetylcholine function is crucial. The aim of this study was to evaluate the inhibitory potential of nine imidazole derivatives against AChE in vitro. In silico Molecular Docking and ADMET studies were conducted on the most potent compounds 3a, 3e, 3g, and 3h to predict their drug-likeness, pharmacokinetics, and toxicity properties. In Addition, we evaluated the potential protective effects of the compound 3a (2-metyl-3H-imidazo[2,1-c][1,2,4]triazol-3-yl)(4-phenyl)methanone), on murine oligodendrocytes (158N) cultured in the absence or presence of 7β-OHC (20 μg/mL, 24 h).
Methods: The cell viability was measured at 570 nm wavelength. We analyzed Catalase (CAT) and glutathione peroxidase (GPx) activity using photometric techniques.
Results: Among the tested compounds, compounds 3a, 3e, 3g, and 3h exhibited significant inhibition effects on acetylcholinesterase (AChE) in comparison to the positive control donopezil. Molecular docking studies indicated that the compound 3a, with a favorable affinity, occupied the active site of AChE. Furthermore, the results demonstrated that a concentration of 31,5μg/mL of compound 3a could attenuate the toxic effect induced by 7β-OHC on 158N cells, and GPx and CAT activities were restored to normal.
Conclusion : These data demonstrate the anticholinesterase and protective activities of (2-metyl-3H-imidazo[2,1-c][1,2,4]triazol-3-yl)(4-phenyl)methanone) against the toxicity induced by 7β-OHC in 158N cells.
The Observation of Retinal Microvascular Alterations in Familial Hypercholesterolemia Patients through Optical Coherence Tomography Angiography
Authors: Wang Xuqian , Chen Peipei , Ma Jin , He Huijing , Zhong Yong , Zhang Shuyang 
Published: September 2023

Abstract

Background: The microcirculation changes in retina of Familial hypercholesterolemia (FH) has been rarely reported previously. We evaluated fundus microvascular alterations in patients with family hypercholesterolemia (FH) through Optical Coherence Tomography Angiography. Methods: Paired sample t-test and Wilcoxon Signed-Rank Test was used to compare the differences of vessel density (VD) and retinal ultrastructure between FH patients and normal controls. The relationship between VD and serum cholesterol level in homozygous FH (HoFH) group was analyzed with multivariate lineal regression. Results: Nineteen eyes of FH patients and 19 eyes of health controls were included. Compared to controls, FH eyes had a larger foveal avascular zone area. The VDs of superficial capillary plexus (SCP) and radial peripapillary capillary (RPC) of FH patients and SCP parafoveal superior area of HoFH patients presented a significant decreasing, while VDs in subsectors of deep capillary plexus (DCP) were significantly increased in both FH group and HoFH group. VDs of SCP in whole image and the parafoveal superior area of HoFH patients were significantly related to serum cholesterol level when adjusting for age, sex, and some clinical signs. Conclusions: The fundus of FH patients demonstrated significant and characteristic microvascular alternations. VDs in some subsectors were also significantly associated with serum cholesterol level.
WITHDRAWN: Dietary Antioxidant Capacity and Serum Total Oxidant/Antioxidant Capacity in Osteoarthritis
Authors: Çolak Beda Büşra Özalp , Kürklü Nilgün Seremet , Adıgüzel Kübra Tel , Adıgüzel Emre 
Published: September 2023

Abstract
Background: The aim of this study was to determine the nutritional status of the osteoarthritis patients and examine the relationship between total oxidant/antioxidant capacity and dietary antioxidant capacity.
Methods: The study was carried out with 47 patients with osteoarthritis (case group) and 30 healthy people (control group) recruited in tertiary health care institutions. Food intakes were measured with the 24-hour recall method and food frequency questionnaire. The dietary antioxidant capacity was estimated with the ferric ion-reducing antioxidant power (FRAP) method. Serum total antioxidant/oxidant capacity was examined by the Erel’s method. The Statistical Package for the Social Sciences (version 22.0) software was used for all analyses. A p-value of less than 0.05 was considered to be statistically significant.
Results: The control and case group were similar of age, gender, and body mass index (p>0.05). It has been observed that 83.0% of individuals with osteoarthritis are overweight or obese. The daily consumption of red meat and butter of the individuals in the case group was higher than that of the control group, and their fish consumption and dietary vitamin A and carotene intakes were found to be lower (p<0.05). Dietary total antioxidant capacity (10.6±3.89 mmol) of case group was found to be lower than the dietary total antioxidant capacity (12.4±3.57 mmol) of the control group (p<0.05). In addition, osteoarthritis (OA) patients have total oxidant capacity (4.6±3.63 and 3.6±1.40 µmol H2O2 Equivalent) and oxidative stress index (0.2±0.05 and 0.2±0.07 AU) was also found to be higher than in control group (p<0.05).
Conclusion: These findings indicated that dietary antioxidant capacity is lower, total oxidant capacity higher in patients with OA than healthy people.