bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANÁLISE COMPUTACIONAL SOBRE ESTAMPABILIDADE DE TAMPAS METÁLICAS PRODUZIDAS A PARTIR DE FOLHA DE FLANDRES
Authors: Camargo Robson , Toniolo Juliano Cantarelli 
Published: January 2025

Este estudo analisa as causas de falhas no processo de estampagem de tampas metálicas fabricadas com folhas de flandres de espessura 0,36 mm. Ensaios mecânicos (tração e análise de anisotropia) e simulações computacionais pelo Método dos Elementos Finitos (MEF) identificaram fatores críticos vinculados às propriedades anisotrópicas do material e aos parâmetros do processo de conformação mecânica. Os resultados experimentais indicaram variações significativas no índice de anisotropia (r) e na resistência mecânica em diferentes direções de laminação, enquanto a simulação computacional destacou regiões suscetíveis a rupturas e deformações. A análise da Curva Limite de Conformação (CLC) revelou que o ponto crítico de tensão está associado a regiões específicas da peça, influenciadas por parâmetros de processo e variabilidade no material. Este trabalho concluiu que ajustes no ferramental, no controle de dureza do material e nos parâmetros de atrito podem reduzir defeitos como rugas e rompimentos, garantindo maior confiabilidade no produto final.
RELATIONSHIP BETWEEN HEPATORENAL INDEX AND ECHOGENICITY OF CAROTID ATHEROSCLEROTIC PLAQUES ACCORDING TO GSM-ANALYSIS IN PATIENTS WITH ASYMPTOMATIC CAROTID ATHEROSCLEROSIS
Authors: Kuznetsova Alla S. , Dolgushina Anastasia I. , Genkel Vadim V. 
Published: January 2025

HighlightsThe severity of liver steatosis is inversely correlated with the echogenicity of carotid atherosclerotic plaques in middle-aged patients with carotid atherosclerosis.Hepatorenal index is an ultrasound marker of hypoechoic carotid atherosclerotic plaques.The inclusion of liver steatosis in cardiovascular risk stratification systems can potentially improve the prediction of adverse cardiovascular events. AnnotationAim. To study the relationship between hepatorenal index (HRI) and echogenicity of carotid atherosclerotic plaques (CAP).Methods. The study included patients with CVD risk factors. The patients' age ranged from 40 to 64 years. The ultrasound study of the brachiocephalic arteries was carried out in standard modes. Echogenicity of CAP in carotid arteries was assessed by GSM-analysis. HRI was defined as the ratio of the median gray scale of the liver to the median gray scale of the kidney. Severity of hepatic steatosis was determined by semiquantitative method using Hamaguchi scale.Results. 139 patients underwent examination according to a unified protocol. Among those patients 104 were selected for the analysis. Assessing the relationship between echogenicity of carotid CAPs, Hamaguchi scale score and HRI, we have found inverse statistically significant correlations. The median GSM of CAP in the study group was 57,0 (39,7; 80,0) conventional units. In order to determine the potential diagnostic value of Hamaguchi scale and HRI for detecting CAPs with lower than median echogenicity for the given group of patients, we performed ROC analysis. According to logistic regression analysis adjusted for sex, age, obesity, and abdominal obesity, an increase in HRI greater than 1,34 was associated with increased odds ratio of carotid CAPs with GSM < 57 conventional units (less than 50th percentile) by a factor of 2,66 (95% CI 1,09–6,45; p = 0,031), whereas the increase associated with CAPs with GSM < 39,7 conventional units (less than 25th percentile) was 2,95-fold (95% CI 1,08–8,08; p = 0,035).Conclusion. The severity of hepatic steatosis as assessed by the Hamaguchi scale and HRI was inversely correlated with the echogenicity of carotid CAPs in middle-aged patients with carotid atherosclerosis. An increase in HRI > 1,34 with 65,8% probability predicted the presence of carotid CAPs with a GSM of less than 57. Odds ratio of carotid CAPs with GSM < 57 conventional units (less than the 50th percentile) and GSM < 39,7 (less than 25th percentile) with HRI values > 1,34 were 2,66 and 2,95, respectively, after adjustment for intervening factors.
EVALUATION OF THE RESULTS OF AORTIC VALVE NEOCUSPIDIZATION WITH AUTOLOGOUS PERICARDIUM USING THE OZAKI TECHNIQUE IN AORTIC ROOT SURGERY
Authors: Isaev Ruslan M. , Komarov Roman N. , Tkachev Maxim I. , Soborov Mark A. , Normuradov Akmal U. , Torchinsky Nikolay V. , Panesh Elena B. , Namiot Evgeniya D. 
Published: January 2025

HighlightsThe main surgical interventions for aortic valve pathology at the aortic root site are aortic valve replacement and redo replacement. The Ozaki procedure emerged in the last decade; it involves replacement of the aortic valve using autologous pericardium. Despite the fact that many centers perform the Ozaki procedure frequently, there are few studies on the comparative evaluation of its efficacy. This necessitated the present study, which compares three groups of patients operated on using different techniques. Aim. To compare the short- and medium-term results of the Ozaki procedure and aortic valve replacements using mechanical and biological valves.Methods. The retrospective study included 189 patients operated on for aortic malformation at the Cardiac Surgery Department of Sechenov University from 2017 to 2022. Three groups of patients were formed: patients undergoing Ozaki procedure were included in the Ozaki group (70 patients), patients undergoing aortic valve replacement using mechanical prosthesis were included in the Mechanical valve group (62 patients), and patients undergoing aortic valve replacement using biological prosthesis were included in the Biovalve group (57 patients). The Ozaki procedure was performed in case the diameter of the aortic annulus was ≤ 25 mm. All mid-term outcomes were assessed after at least 6 months (mean follow up period was 20 months). The primary end points were mean and peak aortic valve gradient, 30-day mortality in the short-term postoperative period, and midterm mortality (≥ 6 months).Results. The mean gradient in the Ozaki, Biovalve, and Mechanical valve groups were 10.67 ± 7.15, 15.94 ± 21, and 17.87 ± 7.52 mm Hg. The peak gradient in the Ozaki group decreased from 81.7 ± 32.5 to 21.01 ± 13.22 mm Hg (in the in-hospital setting). 6 months after surgery, the peak gradient values were 18.98 ± 16.17 mm Hg. The in-hospital mortality rates in the Ozaki, Mechanical valve and Biovalve groups were 2.86, 5.26, and 6.45%, respectively. The overall mid-term mortality in three groups was 6/189, 3.17% (95% CI: 1.5–6.07), p = 0.172.Conclusion. In the short- and mid-term period, Ozaki procedure is superior to aortic valve replacement techniques in terms of aortic valve pressure gradient and comparable in terms of mortality.
COMPARATIVE ANALYSIS OF PULMONARY ARTERY CONDUITS IN CHILDREN
Authors: Kulyabin Yuriy Yu. , Nichay Nataliya R. , Soynov Ilia A. , Dokuchaeva Anna A. , Zhuravleva Irina Yu. , Bogachev-Prokophiev Alexander V. 
Published: January 2025

HighlightsThe review presents the analysis of long-term outcomes of implantation of the most common types of conduits in children. Predictors of the development of dysfunction and infective endocarditis are presented. Aim. To analyze the function of the available types of conduits in pediatric group of patients who underwent right ventricular outflow tract (RVOT) reconstruction.Methods. The retrospective study included patients between 0 and 18 years old who underwent RVOT reconstruction using conduits between 2000 and 2017. Clinical records and imaging data were analyzed.Results. A total of 400 patients underwent implantation of 495 conduits including glutaraldehyde (GA)-treated bovine jugular vein (contegra) (n = 181); GA-treated xenopericardial conduit (BioLAB) (n = 84); diepoxyde (DE)-treated xenopericardial conduit with porcine aortic root (AB-composite) (n = 65); DE-treated xenopericardial conduit (Pilon) (n = 32) and cryopreserved pulmonary homograft (n = 135). Primary implantation was made in 383 cases (77.3%) and conduit reimplantation was made in 112 cases (22.5%). Median follow-up was 79.9 (42.6; 110.7) months. Redo surgery with conduit replacement was made in 41 (8.5%) cases, of these, 6 (2.1%) conduits were replaced due to thrombosis, endocarditis was diagnosed in 14 patients (4.8%), there were no statistical differences between the groups. Younger age was associated with high risk of early dysfunction (OR 0.97; 95% CI 0.96–0.99, p = 0.03). Multivariate analysis revealed that the type of conduit was not a risk factor (OR 0,86; 95% CI 0,64–1,15; p = 0,64). Severe calcification was the main predictor of conduit-associated mortality (OR 0.02; 95% CI 0.002–0.34; p = 0.005).Conclusion. Incidence of reintervention due to conduit dysfunction is still high in pediatric group and is not associated with type of conduit. All types of available conduits showed comparable rates of dysfunction. Risk of developing conduit-associated infective endocarditis also does not depend on the type of implanted graft.
MULTIDISCIPLINARY APPROACH TO TREATMENT OF PATIENT WITH BIOPROSTHETIC AORTIC VALVE DYSFUNCTION AND RENAL CELL CARCINOMA WITH TUMOR THROMBUS
Authors: Alekyan Bagrat G. , Gritskevich Alexander A. , Karapetyan Narek G. , Chevina Alina A. , Tokmakov Evgeny V. , Gyoletsyan Lilit H. , Polotbek uulu Zholboldu , Galstyan Artur V. , Titov Nikita S. , Grigoryan Marina V. , Savin Leonid T. , Karelskaya Natalia A. , Revishvili Amiran S. 
Published: January 2025

HighlightsThis review presents a clinical case of a patient with a rare combination of two life-threatening pathologies whose treatment required high-tech surgery. The effectiveness of a multidisciplinary approach to treatment has been demonstrated. AnnotationAortic stenosis (AS) is the most common heart disease in elderly patients requiring treatment. Malignant neoplasms of the kidneys account for about 3% of all cancers in the Russian Federation, and the formation of tumor thrombi in the renal and inferior vena cava occurs in 4–10% of patients with this pathology. Given the prevalence of aortic stenosis and renal cell carcinoma (RCC), the number of patients with a combination of these two conditions keeps increasing and they are recommended to undergo surgical treatment at multidisciplinary clinical centers. Transcatheter aortic valve implantation (TAVI) and radical nephrectomy with intracorporeal thrombectomy using the DaVinci Si robotic surgical system may be a preferred approach for the treatment of critical AS and RCC for this category of patients.At the multidisciplinary clinical center a patient with dysfunctional bioprosthetic aortic valve implanted in 2010 and NYHA class 3 heart failure with history of endovascular treatment of coronary artery disease, peripheral arterial disease and carotid endarterectomy and concomitant renal cell carcinoma with tumor thrombosis of the renal vein received surgical treatment in 2 stages: TAVI – the first stage, and robot-assisted right-sided nephrectomy and thrombectomy from the renal vein – the second stage. The patient was discharged from the Center on the 7th day after TAVI and on the 6th day after surgery for renal cancer. Six months after the procedure, there was a decrease in the functional class of heart failure, satisfactory function of the transcatheter aortic valve bioprosthesis, decrease in the size of the left ventricle, decrease in the brain natriuretic peptide, and the absence of cancer progression.
Determination of Mequitazine in Tablets by Difference Spectrophotometry Based on the Absorption of its Sulfoxide
Authors: Blazheyevskiy Mykola , Iurchenko Ivan 
Published: January 2025

A new method is described for the rapid determination of (R)-(+)-Mequitazine. The drug is determined by a difference spectrophotometric technique based upon the absorbance of its sulphoxide derivative relative to the absorbance of a solution of the underivatized drug. The sulphoxide derivative are formed rapidly and quantitatively at room temperature by the addition of a solution of potassium caroate in form Oxone. The difference absorbance of the solutions is proportional to the concentration of the Mequitazine in the preparation and is specific for the intact drug in the presence of oxidative and photochemical decomposition products and excipients. Linearity range 1.00–35.00 µg/mL. The regression line equation is ΔA (342 nm) =0.05×C (r=0.99) where C is in µg/ml Mequitazine. The limit of quantitation, LOQ (10S), is 1.0 µg/mL. The possibility of quantitative determination of Mequitazin in Primalan 10 mg tablets has been demonstrated. RSD ≤ 1.5%; ((– µ) 100%/µ =+0.80%). ‘µ’ is data of quantitative determination by the reference pharmacopoeial method.
Cytotoxicity of Alkyl Derivatives of Protocetraric Acid
Authors: Bogo Danielle , Alcantara Glaucia , Camila Micheletti Ana , Honda Neli , Cepa Matos Maria de Fátima 
Published: January 2025

The protocetraric acid (1) is a depsidone produced by countless species of lichens and has shown potential biological activity. In this work, we evaluated through the sulforhodamine B (SRB) assay the cytotoxic activity of seven alkyl ether derivatives of protocetraric acid (9´-O-alkyl protocetraric acid) against the following cell lines: HT-29 (colon carcinoma), 786-0 (kidney carcinoma), MCF7 (breast carcinoma), HEP2 (laryngeal carcinoma), PC-03 (prostate carcinoma), B16F10 (murine melanoma), UACC-62 (human melanoma), and NIH/3T3 (mouse embryonic fibroblast). Most compounds were cytotoxic to tested cells, with GI50 < 100.0 μM, and did not show selectivity over them.
Evaluation of outcomes in elderly patients undergoing hemiarthroplasty for femoral neck fractures
Authors: Kamble Suhas Laxman , Kamble Raj Suhas , Jadhav Pradeep Dnyanprakash 
Published: January 2025

Femoral neck fractures are a prevalent orthopedic challenge among the elderly, often associated with significant morbidity, mortality, and a decline in functional independence. Hemiarthroplasty, a surgical intervention that replaces the femoral head, is commonly employed for managing displaced femoral neck fractures in this demographic. This comprehensive review evaluates the outcomes of hemiarthroplasty, focusing on functional recovery, perioperative and long-term complications, and survival rates. The review highlights the critical role of surgical factors, including the choice between cemented versus cementless and bipolar versus unipolar prostheses, in influencing postoperative outcomes. Furthermore, patient-related factors such as age, gender, and comorbidities, along with the timing of surgery and the quality of postoperative care, are examined for their impact on recovery and mortality.The article synthesizes evidence from peer-reviewed studies to provide insights into the efficacy of hemiarthroplasty in restoring mobility and improving quality of life, while also addressing common complications like infection, dislocation, and prosthesis loosening. Economic implications are discussed, emphasizing the cost-effectiveness of hemiarthroplasty compared to alternative treatments. By exploring predictors of both favorable and adverse outcomes, this review underscores the importance of personalized surgical planning and multidisciplinary postoperative management in optimizing patient outcomes. The findings aim to guide clinicians in making informed decisions and highlight areas for future research to enhance the care of elderly patients with femoral neck fractures.
Old unreduced dorsal fracture dislocation of index finger (kaplan injury) – A case report
Authors: Bagul Jayesh , Angachekar Dhruva , Ponde Saurabh , Singh Samarth , Sirsat Prashik , Singh Ashish 
Published: January 2025

Kaplan’s injury is complex dislocations of metacarpophalangeal joint. The metacarpal head is dislocated and is volar plate goes dorsal to it making it unreducible by closed method. We present a case of Kaplan injury along with an osteochondral fracture of metacarpal head of second digit of right hand. We have used dorsal approach to avoid vascular injury and to address the osteochondral fracture fragment. The dislocation was fixed with k wires. Good functional outcome was seen at 6 months. There is ongoing discussion regarding the best approach to treat these lesions. Dorsal approach with k wiring provides good functional outcomes in cases of Kaplan injury.
Religion and Social Movements in Indonesia
Authors: Kuswana Dadang , Sumpena Deden , Hendra Hardiyan Syah Yoshy 
Published: January 2025

This article examines the role of religion in contemporary social movements in Indonesia using the framework of relative deprivation theory. The phenomenon of religion-based social movements has become an integral part of the socio-political dynamics of post-Reformation Indonesia. This research presents three cases of significant religion-based social movements in Indonesia in the last decade. The cases chosen for in-depth analysis include: Action Defending Islam 2016-2017 (also known as the "212 movement"), the #2019ChangePresident Movement, and the Movement to reject the 2020 Job Creation Omnibus Law. This study examines how perceptions of injustice and socio-economic inequality trigger mass mobilization based on religious identity. This research adopts a qualitative research method with a multiple case study design. Through critical analysis of three recent cases of social movements, this research reveals the complexity of the interaction between religious, economic and political factors in shaping collective action. The findings show that, while relative deprivation plays a significant role in motivating participation in religious social movements, contextual factors such as political opportunity structures and organizational resources also play an important role. The theoretical and practical implications of these findings are discussed in the context of efforts to build social cohesion and conflict management in a diverse Indonesia
Perlindungan Hukum Hak Kekayaan Intelektual Atas Produk Pengolahan Ikan Di Dusun Sendangbiru Desa Tambakrejo Kecamatan Sumbermanjing Wetan Kabupaten Malang
Authors: Ambarsari Ririen , Wijaya Darajatun Indra Kusuma , Zakaria Fahmi Arif 
Published: January 2025

Kabupaten Malang, Kecamatan Sumbermanjin-Wetang, Desa Tambakrejo dan Dusun Sendanbil mempunyai potensi besar dalam pengolahan hasil laut seperti ikan tuna yang kaya protein. Meskipun potensi ini dapat mendukung kesejahteraan masyarakat, terbatasnya wawasan terhadap perlindungan hak kekayaan intelektual (HAKI), khususnya merek dagang, menjadi hambatan dalam pemasaran produk olahan makanan laut. Penelitian ini bertujuan untuk menggali potensi sumber daya kelautan untuk menunjang kesejahteraan. Survei masyarakat di Dusun Sendanville, (2) Penelitian tentang perlindungan hukum kekayaan intelektual produk olahan hasil laut. Kajian ini menyoroti perlunya dukungan masyarakat untuk memahami pentingnya merek untuk melindungi hak kekayaan intelektual agar produk olahan seperti sutra ikan memenuhi standar pasar. Upaya tersebut diharapkan dapat meningkatkan daya saing produk dan mengembangkan perekonomian Dusun Sendanville secara berkelanjutan.
Tanggung Jawab Hukum Perusahaan Asuransi Jiwa Terhadap Kegagalan Pembayaran Klaim Asuransi Jiwa Bakrie
Authors: Dwi Syafi'i Azhari , Putra Widiyanto Alif , Farros Friyadhi Naufal , Kartika Dewi Ulva , Aora Fadilla Dea , Lubis Thondi , Aryanti Ramadhani Dwi 
Published: January 2025

Dalam era kemajuan teknologi, kebutuhan manusia yang semakin kompleks mendorong pentingnya sebuah perlindungan melalui asuransi. Kasus perusahaan asuransi jiwa PT Bakrie Life, menarik perhatian karena tantangan pembayaran klaim terkait produk inovatif mereka, Diamond Investa, saat krisis ekonomi global. Fokus penelitian adalah memahami perlindungan hukum bagi pemegang polis dan tanggung jawab perusahaan terkait kegagalan pembayaran klaim. Penelitian ini menggunakan pendekatan Kualitatif Studi Kasus dengan menganalisis secara mendalam terhadap isu-isu hukum yang terjadi pada kasus gagal bayar PT Bakrie Life serta melakukan studi literatur terhadap sumber - sumber bacaan yang terkait dengan permasalahan yang diteliti. Hasil dari penelitian ini diharapkan dapat memberikan wawasan kepada pembaca tentang pentingnya transparansi dan kewajiban perusahaan asuransi dalam melindungi pemegang polis dari risiko keuangan yang tidak terduga serta menekankan bahwa perlunya sebuah keseimbangan antara inovasi produk dan tanggung jawab hukum untuk memastikan keamanan finansial bagi para pemegang polis.
Human umbilical cord mesenchymal stem cell exosomes promote elastin production and acute skin wound healing via TGFβ1-Smad pathway
Authors: Zi Yi , Li Jie , Qian XinPing , Li Jian , Jin Yan , Zhang ZiBo , Jin YanHua 
Published: January 2025

Abstract

Background Skin wound healing is a complex physiological process influenced by multiple factors, including the patient's overall health status. Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-exos) have demonstrated considerable potential in enhancing wound repair. This study investigates the mechanisms through which hUCMSC-exos facilitate skin wound healing and evaluates their potential application in combination with hydrogels for clinical treatment. Method Human foreskin fibroblasts (HFF-1) were treated with varying concentrations of hUCMSC-exos to evaluate their impact on cell proliferation, assessed via the CCK-8 assay. Exosome uptake by HFF-1 cells was visualized using PKH26 dye staining, while flow cytometry was employed to analyze cell cycle changes. Cell migration was evaluated through scratch and Transwell assays. Gene expression levels of Collagen I, Elastin, and Fibronectin were quantified by qRT-PCR, while Elastin secretion was measured by ELISA. Western blotting was used to examine proteins in the TGFβ1-Smad signaling pathway. The role of SP1 in regulating Elastin gene expression was investigated by testing the SP1 inhibitor Plicamycin and examining hUCMSC-exos' ability to counteract its effect. Additionally, a chromatin immunoprecipitation (ChIP) assay was performed to analyze SP1 binding at the Elastin gene promoter. In vivo, the efficacy of hUCMSC-exos combined with hydrogels in promoting wound healing was assessed using a mouse skin wound model. Results hUCMSC-exos significantly enhanced HFF-1 cell proliferation at concentrations exceeding 1×10⁹ particles/mL and increased the proportion of cells in the S and G2/M phases. HFF-1 cells readily absorbed these exosomes, leading to improved cell migration. Treatment with hUCMSC-exos upregulated the gene expression of Collagen I, Fibronectin, and Elastin. The SP1 inhibitor Plicamycin reduced Elastin gene expression, an effect that was reversed by hUCMSC-exos. In vivo, the combination of hUCMSC-exos and hydrogels accelerated wound healing, enhanced collagen organization, and promoted the formation of elastic fibers and blood vessels. Conclusions hUCMSC-exos facilitate skin wound healing by promoting SP1 binding to the Elastin gene promoter, thereby upregulating Elastin expression and supporting extracellular matrix remodeling. These findings suggest a promising therapeutic role for hUCMSC-exos in clinical applications for wound healing.