bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD8α+ dendritic cells potentiate antitumor and immune activities against murine ovarian cancers
Authors: Lee Shin-Wha , Lee Hyunah , Lee Kyung-Won , Kim Min-Je , Kang Sung Wan , Lee Young-Jae , Kim HyunSoo , Kim Yong-Man 
Published: January 2023

AbstractDendritic cell (DC)-based immunotherapies have been shown to be a potential treatment option for various cancers; however, the exact strategies in ovarian cancer remain unknown. Here, we report the effectiveness of mouse CD8α+ DCs derived from bone marrow hematopoietic stem cells (BM-HSCs), equivalent to human CD141+ DCs, which have proven to be a highly superior subset. Mono-DCs from monocytes and stem-DCs from HSCs were characterized by CD11c+ CD80+ CD86+ and CD8α+ Clec9a+ expression, respectively. Despite a lower dose compared with Mono-DCs, mice treated with pulsed Stem-DCs showed a reduced amount of ascitic fluid and lower body weights compared with those of vehicle-treated mice. These mice treated with pulsed stem-DCs appeared to have fewer tumor implants, which were usually confined in the epithelium of tumor-invaded organs. All mice treated with DCs showed longer survival than the vehicle group, especially in the medium/high dose pulsed Stem-DC treatment groups. Moreover, the stem-DC-treated group demonstrated a low proportion of myeloid-derived suppressor cells and regulatory T cells, high interleukin-12 and interferon-γ levels, and accumulation of several tumor-infiltrating lymphocytes. Together, these results indicate that mouse CD8α+ DCs derived from BM-HSCs decrease tumor progression and enhance antitumor immune responses against murine ovarian cancer, suggesting that better DC vaccines can be used as an effective immunotherapy in EOC treatment. Further studies are necessary to develop potent DC vaccines using human CD141+ DCs.
Butchering knives and hafting at the Late Middle Paleolithic open-air site of Nahal Mahanayeem Outlet (NMO), Israel
Authors: Martin-Viveros Juan Ignacio , Oron Maya , Ollé Andreu , Chacón M. Gema , Sharon Gonen 
Published: January 2023

AbstractMuch of what is known about human behavior and subsistence strategies in the Levantine Middle Paleolithic comes from long sequences from caves and rock shelters. In this context, studies of stone tool function have traditionally focused on determining the use of Levallois points and triangular elements, either as projectiles or, more rarely, multipurpose knives. Little is known about such tool use and hafting in Middle Paleolithic open-air sites in the Levant through the systematic application of micro-wear analysis. Here we report the results of a low and high-power study performed on the lithic assemblage of the Late Middle Paleolithic open-air site of Nahal Mahanayeem Outlet (NMO, Israel). Most pointed items, including Levallois and non-Levallois points, were used as butchering knives, many of them while hafted; to a much lesser extent they were also used for hide, bone, and wood/plant processing activities. Blades and flakes were mostly handheld and used as butchering knives, with hide, bone, antler, and wood/plant-processing tasks being rare. Hafted artifacts include morphologies and activities for which hafting is not required, indicating that NMO inhabitants possessed varied hafting expertise. Wood/plant processing tools, some of which were hafted, attest that manufacture and maintenance tasks were planned well in advance of game procurement at the site. These results attest to early evidence of hafted butchering knives and hafted plant processing tools for a Late Middle Paleolithic open-air site in the Levant, and support previous interpretations of NMO as a short-term task-specific location focused on animal processing activities, mostly butchery.
The evolution of digital health technologies in cardiovascular disease research
Authors: Zwack Clara C. , Haghani Milad , Hollings Matthew , Zhang Ling , Gauci Sarah , Gallagher Robyn , Redfern Julie 
Published: January 2023

AbstractWhen implemented in practice, digital technologies have shown improvements in morbidity and mortality outcomes in patients with cardiovascular disease (CVD). For scholars, research into digital technologies in cardiovascular care has been relatively recent, thus it is important to understand the history of digital health technology in cardiovascular research—its emergence, rate of growth, hot topics, and its temporal evolution. The aim of this study was to analyse more than 16,000 articles in this domain based on their scientometric indicators. Web of Science (WoS) Core Collection was accessed and searched at several levels, including titles, abstracts, keywords, authors, sources and individual articles. Analysis examined the temporal shifts in research and scholarly focus based on keywords, networks of collaboration, topical divisions in relation to digital technologies, and influential publications. Findings showed this research area is growing exponentially. Co-citation analysis revealed twenty prominent research streams and identified variation in the magnitude of activities in each stream. A recent emergence of research activities in digital technology in cardiovascular rehabilitation (CR), out-of-hospital cardiac arrest (OHCA), and arrythmia research was also demonstrated. Conversely, wearable technologies, activity tracking and electronic medical records research are now past their peak of reported research activity. With increasing amounts of novel technologies becoming available and more patients taking part in remote health care monitoring, further evaluation and research into digital technologies, including their long-term effectiveness, is needed. Furthermore, emerging technologies, which are evaluated and/or validated should be considered for implementation into clinical practice as treatment and prevention modalities for CVD.
The bHLH-zip transcription factor SREBP regulates triterpenoid and lipid metabolisms in the medicinal fungus Ganoderma lingzhi
Authors: Liu Yong-Nan , Wu Feng-Yuan , Tian Ren-Yuan , Shi Yi-Xin , Xu Zi-Qi , Liu Ji-Ye , Huang Jia , Xue Fei-Fei , Liu Bi-Yang , Liu Gao-Qiang 
Published: January 2023

AbstractGanoderic acids (GAs) are well recognized as important pharmacological components of the medicinal species belonging to the basidiomycete genus Ganoderma. However, transcription factors directly regulating the expression of GA biosynthesis genes remain poorly understood. Here, the genome of Ganoderma lingzhi is de novo sequenced. Using DNA affinity purification sequencing, we identify putative targets of the transcription factor sterol regulatory element-binding protein (SREBP), including the genes of triterpenoid synthesis and lipid metabolism. Interactions between SREBP and the targets are verified by electrophoretic mobility gel shift assay. RNA-seq shows that SREBP targets, mevalonate kinase and 3-hydroxy-3-methylglutaryl coenzyme A synthetase in mevalonate pathway, sterol isomerase and lanosterol 14-demethylase in ergosterol biosynthesis, are significantly upregulated in the SREBP overexpression (OE::SREBP) strain. In addition, 3 targets involved in glycerophospholipid/glycerolipid metabolism are upregulated. Then, the contents of mevalonic acid, lanosterol, ergosterol and 13 different GAs as well as a variety of lipids are significantly increased in this strain. Furthermore, the effects of SREBP overexpression on triterpenoid and lipid metabolisms are recovered when OE::SREBP strain are treated with exogenous fatostatin, a specific inhibitor of SREBP. Taken together, our genome-wide study clarify the role of SREBP in triterpenoid and lipid metabolisms of G. lingzhi.
Genome-wide sequencing identifies a thermal-tolerance related synonymous mutation in the mussel, Mytilisepta virgata
Authors: Tan Yue , Ma Chao-Yi , Li Xiao-Xu , Han Guo-Dong , Dong Yun-Wei 
Published: January 2023

AbstractThe roles of synonymous mutations for adapting to stressful thermal environments are of fundamental biological and ecological interests but poorly understood. To study whether synonymous mutations influence thermal adaptation at specific microhabitats, a genome-wide genotype-phenotype association analysis is carried out in the black mussels Mytilisepta virgata. A synonymous mutation of Ubiquitin-specific Peptidase 15 (MvUSP15) is significantly associated with the physiological upper thermal limit. The individuals carrying GG genotype (the G-type) at the mutant locus possess significantly lower heat tolerance compared to the individuals carrying GA and AA genotypes (the A-type). When heated to sublethal temperature, the G-type exhibit higher inter-individual variations in MvUSP15 expression, especially for the mussels on the sun-exposed microhabitats. Taken together, a synonymous mutation in MvUSP15 can affect the gene expression profile and interact with microhabitat heterogeneity to influence thermal resistance. This integrative study sheds light on the ecological importance of adaptive synonymous mutations as an underappreciated genetic buffer against heat stress and emphasizes the importance of integrative studies at a microhabitat scale for evaluating and predicting the impacts of climate change.
Appearance and suppression of Turing patterns under a periodically forced feed
Authors: Dúzs Brigitta , Holló Gábor , Kitahata Hiroyuki , Ginder Elliott , Suematsu Nobuhiko J. , Lagzi István , Szalai István 
Published: January 2023

AbstractTuring instability is a general and straightforward mechanism of pattern formation in reaction–diffusion systems, and its relevance has been demonstrated in different biological phenomena. Still, there are many open questions, especially on the robustness of the Turing mechanism. Robust patterns must survive some variation in the environmental conditions. Experiments on pattern formation using chemical systems have shown many reaction–diffusion patterns and serve as relatively simple test tools to study general aspects of these phenomena. Here, we present a study of sinusoidal variation of the input feed concentrations on chemical Turing patterns. Our experimental, numerical and theoretical analysis demonstrates that patterns may appear even at significant amplitude variation of the input feed concentrations. Furthermore, using time-dependent feeding opens a way to control pattern formation. The patterns settled at constant feed may disappear, or new patterns may appear from a homogeneous steady state due to the periodic forcing.
Past rainfall-driven erosion on the Chinese loess plateau inferred from archaeological evidence from Wucheng City, Shanxi
Authors: Xiong Li-Yang , Li Si-Jin , Hu Guang-Hui , Wang Ke , Chen Min , Zhu A-Xing , Tang Guo-An 
Published: January 2023

AbstractThe history of changes in the Earth’s surface can be investigated by numerical modelling of landform evolution. However, such models rely on evidence which is often removed through erosion or other surface processes. Here, we use archaeological observations from the remains of Wucheng City in Shanxi, China, which was built on a loess area during the Neolithic period, to reconstruct the paleo-surface of the area and inform a landform evolution model. We identify differences between the present-day and paleo-land surface which suggest the topography was previously much less rugged. We find that period of heightened erosion rate in the early Holocene coincides with the period of increased rainfall, suggesting climate was the primary control on landform evolution during this time. We conclude that paleo-surface observations taken from archaeological sites, as demonstrated by this study, are valuable tools to inform landform evolution models in other regions where evidence is limited.
Survey of Communication Sciences and Disorders Applicants: Factors That Influence Graduate School Selection
Authors: King Alison , Power-deFur Lissa A. , Perry Jeannine , Wind Erin , Anderson Sarah 
Published: January 2023

Purpose:
The purpose of this study was to provide a comprehensive analysis of the aspects within speech-language pathology programs that students deem to be important or relevant as they apply to and subsequently select a graduate program.

Method:
Data were collected through an online survey of 627 individuals who had applied to a master's degree program in speech-language pathology. Ninety-nine applicants participated in the survey (15.7% response rate) with approximately half (46%) providing information to an open-ended question. Survey questions explored 28 different factors for consideration.

Results:
Respondents indicated that clinical opportunities on and off campus, ability to attend full time, and responsiveness of the university to inquiries were the top most important factors when deciding where to apply and then attend graduate school. The top factors considered not important, or irrelevant, included attending a large university, ability to attend part time, and the program being located in a small town/city. An open-ended response question identified other factors applicants valued, including diversity within the program, diversity of clients, the campus community, and university supports.

Conclusions:
Results from this study identified factors important to communication sciences and disorders (speech-language pathology) graduate program applicants to a small, public university in rural Virginia and supported findings from previous studies. Furthermore, additional factors emerged including university assistance and supporting students from diverse backgrounds. Graduate programs can use these findings in developing and refining programs and in recruiting students to their programs.
Induced voltage at the closest pole on parallel line due to direct triggered lightning on 10 kV double circuit distribution line
Authors: Zhao Yating , Wang Jianguo , Cai Li , Li Quanxin , Fang Yuqian , Su Rui , Wang Shoupeng , Zhou Mi 
Published: January 2023

AbstractIn 2019, triggered lightning was used to directly strike phase C of a 1.5 km, 10 kV double‐circuit distribution line in Guangzhou, China, with 2 flashes (13 return strokes) recorded. This paper presents the characteristics of induced voltage at the closest pole on the parallel line. The induced voltage is bipolar, which can be divided into 3 stages: negative increase stage, fast and positive transition stage and slowly returning to zero stage. The positive peak value of phase A voltage ranges from 111.4 to 228.9 kV and that of phase C voltage is from 90.1 to 200.9 kV, corresponding to lightning current from −8.9 to −29.9 kA. The positive peak value of the induced voltage is approximately 3 to 10 times the negative peak value. The negative peak, positive peak and positive 10%–10% duration time of induced voltage show a good linear relationship with the peak value of the return stroke current. There was no flashover occurred during the whole process. The result in this paper can provide data support for numerical simulation and line protection analysis.
Network partitioning and hierarchical voltage regulation for distribution networks using holomorphic embedding method‐based sensitivity
Authors: Zhang Ren , Liu Haoming , Yang Meng , Wang Jian , Shang Jie 
Published: January 2023

AbstractThe fluctuation of photovoltaics (PVs) output may cause the voltage out‐of‐limit, while the PV inverters and hybrid distribution transformers (HDTs) bring flexible controllability to distribution networks (DNs). However, there are differences in response speeds between power electronic equipment and traditional discrete regulating equipment. Therefore, a network partitioning and hierarchical voltage regulation method using holomorphic embedding method (HEM) ‐based sensitivity is proposed. Firstly, the HEM‐based voltage sensitivity is derived, and the network partitioning method is proposed using the HEM‐based sensitivity matrix. Then, the hierarchical voltage regulation framework is constructed. The objects of the upper layer are the minimum network loss and voltage deviation, which centrally optimizes the operation status of discrete regulation equipment. The lower layer exploits the fast control ability of PV inverters and HDTs, so as to autonomously regulate the voltage of each partition. Finally, a practical 10 kV DN in China is used for case studies. The results demonstrate that the HEM‐based voltage sensitivity calculation method has advantages in computational efficiency and accuracy compared with the conventional method. Moreover, the proposed voltage regulation method can suppress the voltage fluctuation.
Enhanced three‐dimensional model reconstruction based on local ternary pattern‐guided fusion of multi‐exposure images
Authors: Chan Kwok‐Leung , Li Liping , Leung Arthur Wing‐Tak , Chan Ho‐Yin 
Published: January 2023

AbstractComputer vision applications usually rely on the features extracted from input images with good visibility. Image acquisition systems may produce degraded images with low contrast or distorted colours. For instance, bad weather (haze, fog) can cause images captured outdoor with low visibility. Image processing algorithms generally assume that the input image is the scene radiance. Haze removal, with the recovery of image radiance, ensures reliable features extracted from images and the image processing algorithm can achieve optimal performance. Inspired by the concept of image dehazing, the authors propose an image enhancement method that can be used to improve the visibility of the images. Each original image is first transformed into multiple exposure images by means of gamma‐correction operations and adaptive histogram equalization. The transformed images are analyzed by the computation of the local ternary pattern. The image is then enhanced, with each pixel generated from the set of transformed image pixels weighted by a function of the local pattern feature. The authors evaluate their proposed method on four benchmark image dehazing datasets. The quantitative results show that our method outperforms many deterministic algorithms and deep learning models. Moreover, the authors investigate the impact of image enhancement on a practical image‐based application—the reconstruction of three‐dimensional (3D) model of survey scene. Accurate 3D model reconstruction depends on high‐quality images. Degraded images will result in large errors in the reconstructed 3D model. Experimentations have been carried out on outdoor and indoor surveys. Our analysis finds that when fed into the photogrammetry software, the images enhanced by the authors’ method can reconstruct 3D scene models with sub‐millimetre mean errors, which are much better than those with the original images. As shown in the visual and quantitative results of 3D model reconstruction, the authors’ proposed method also outperforms other image enhancement methods.
Reactive power control in renewable rich power grids: A literature review
Authors: Kumar C. , Lakshmanan M. , Jaisiva S. , Prabaakaran K. , Barua Sourav , Fayek Hady H. 
Published: January 2023

AbstractRecently, there is vast progress in the integration of renewable energy generators (REGs) into the power grid. The reactive power, which is indeed a fundamental power system factor is being influenced highly by the renewable power penetration levels. As a consequence, this has paved the way toward the generation of steady‐state voltage and dynamic/transient stability issues. Therefore, to provide a sustainable and dependable power grid, it is indeed important to maintain and control adequate reactive power reserves. This study introduces a comprehensive literature survey on “management of reactive power in renewable‐rich power networks”. A total of 75 research publications have been collected for this study, and a concise summary of each article is offered. The articles are categorized according to the types of REGs used, type of control, grid code consideration, controller device, implementation tools, grid type, load type as well as various reactive power support systems. In addition, this study examines the advantages and drawbacks of existing models. The performance recorded in each of the collected papers are discussed. Ultimately, the most critical challenges related to management of reactive power in renewable‐rich power grids are identified, along with some essential methodological suggestions for the electricity sector, regulators, and research scientists.
Implications of the POCSO Act and determinants of child sexual abuse in India: insights at the state level
Authors: Maity Shrabanti , Chakraborty Pronobesh Ranjan 
Published: January 2023

AbstractChild sexual abuse is a worldwide phenomenon, and India is not an exception. The magnitude of this grave crime is underrated because of under-reporting. The reality is that the incidence of child sexual abuse has reached epidemic proportions in India. In 2021 only there were 53,874 cases registered under Protection of Children from Sexual Offences Act of 2012. To enable the all-around protection of children, the Indian government administrated the “Protection of Children from Sexual Offences (POCSO)” Act of 2012. The act is a comprehensive piece of legislation designed to protect children from crimes including sexual assault, sexual harassment, and pornography. The degree to which this act has improved child protection is therefore an important issue for interrogation. Here, we consider the implications of the POCSO Act (2012) in enhancing children’s protection from sexual abuse and pin-point the role of quality of life together with other social, economic, and demographic determinants in foreshortening POCSO incidences. The empirical analysis of the paper is conducted based on secondary data compiled from National Crime Records Bureau. Our empirical results reveal that the POCSO Act has reduced the Growth rate of incidents of sexual offences against children in India from 4.681% to −4.611. Moreover, our empirical results also reveal that by enhancing the quality of life it is possible to restrict the POCSO incidences across Indian states. In addition, favourable sex-ratio, the increased gross enrolment ratio at the elementary level, the improvement in the judiciary and Public Safety Score of the state also enables the state to restrict the POCSO incidences. Based on our empirical result we recommend that future policies could include, for instance, aiming to improve the quality of life as well as the law and order conditions of the state, and increasing the enrolment of the girl children in higher education.
More support for hydrogen export than its domestic application in Australia
Authors: Bharadwaj Bishal , Weder Franzisca , Ashworth Peta 
Published: January 2023

AbstractEarly research has suggested the societal acceptance of hydrogen to decarbonise our energy supply is relatively high. However, the specific aspects of hydrogen that citizens support remain unknown. To investigate public support for export and domestic applications of hydrogen, this study implemented an Australian nationally representative survey. Using a quasi-experimental design, information was provided to respondents as an intervention to test individual responses. The information included a short video, followed by images and text descriptions. The study found the combined information package increased societal support by 10% when compared to the baseline with the change in support for export applications being significantly higher compared to domestic applications. While encouraging the development of Australia’s export industry it was also found that respondents’ general support depends on their socio-economic characteristics and geographic location.