bluuebunny/crossref_metadata_2025_split huggingface dataset:
KIRIM TATAR TÜRKÇESİNDE TABU VE ÖRTMECELER ÜZERİNE
Authors: ATMACA Emine , GÖZDAŞ Reshıde 
Published: December 2022

Polinezce kökenli “işaretlenmiş, belirlenmiş” mânasına gelen tabu, insan davranışlarıyla ilgili güçlü sosyal yasak ve kısıtlamaları ifade eder. Tabuların ortaya çıkışında gelenek, görenek, mitler, adet, örf, inanç ve ahlaki değerler, doğal afetler, salgın hastalıklar vb. etkin rol oynar. Bu sebeple tabu konusu üzerindeki çalışmalar, etnografik/kültürel antropoloji dilciliğin temelinde ele alınmalıdır. İnsanlar, bazen konuştuğu konunun muhatabı rahatsız edebileceğini, acı veya utanç getirebileceğini varsaydığında söylemeye çekinir ve bazı kelimeleri ya gizleyerek ya da yumuşak bir şekilde ifade etmeye çalışır. Bu durumda örtmeceler / örtükanlatım dediğimiz terim devreye girer, kelimenin veya kavramın semantik yönü ve anlam alanı değiştirilmeye çalışılır. Böylelikle muhataba adları doğrudan değil, dolaylı olarak söylenmiş olur. Dilin sosyo-psikolojik boyutunda yer alan örtmeceler, ölüm, cinsellik, din ve hastalık gibi toplum tarafından belli ritüelleri ve yasakları olan olaylarda kendini sıklıkla gösterir.
Bu çalışmada, Kırım Tatar Türkçesinin söz varlığında hangi tür kavram ve kelimelerin tabulaştığı, onların yerine ne tür örtmece kelimelerin kullanıldığı, bu kelimelerin ortaya çıkış sebepleri, anlam ve yapısal vb. özellikleri üzerinde durulmuştur. Millî, yerel, geleneksel ve tarihsel boyutları olan tabu ve örtmece terimlerinin oluşum mantığı ve yolları ayrıntılı olarak ele alınmıştır.
Lingkungan Permukiman Sehat dengan Penerapan Septic tank Muka Air Tanah Tinggi dalam Proses Penanganan Limbah Kakus Padat di Desa Mata Wawatu Kecamatan Moramo Utara Kabupaten Konawe Selatan
Authors: Kadir Ishak , Jaya La Ode M. Golok , Rachman Ranno Marlany , Ma'ruf Annas , Santi Santi , Hasan La Ode Amrul 
Published: December 2022

Desa Mata Wawatu Kecamatan Moramo Utara Kabupaten Konawe Selatan memiliki karakter topografi lingkungan permukiman yang menarik karena kelompok rumah masyarakat sebagian berada pada wilayah muka air tanah tinggi dan sebagian kelompok rumah masyarakat berada di dataran yang terjadi genangan air tinggi pada saat hujan tinggi. Berdasarkan survei awal yang dilakukan, umumnya masyarakat belum memiliki septic tank dan tidak memahami pengelolaan limbah rumah tangga khususnya limbah kakus yakni kotoran pada manusia.Tujuan kegiatan ini untuk meningkatkan pemahaman, pengetahuan dan partisipasi masyarakat dalam upaya peningkatan lingkungan sehat dengan penerapan septic tank muka air tanah tinggi dalam proses penanganan limbah kakus padat di Desa Mata Wawatu Kecamatan Moramo Utara Kabupaten Konawe Selatan, serta terbangunnya jamban dalam upaya peningkatan sanitasi lingkungan sehat dengan penerapan septic tank muka air tanah tinggi dalam proses penanganan limbah kakus padat di Desa Mata Wawatu Kecamatan Moramo Utara Kabupaten Konawe Selatan.Berdasarkan hasil survey dan identifikasi kondisi sanitasi masyarakat Desa Mata Wawatu meskipun mayoritas masyarakat telah memiliki septic tank diseluruh dusun tapi masih terdapat 18 unit rumah yang menggunakan cumplung atau cubluk. Perlu ada usaha untuk membantu dalam proses pergantian ke septic tank air muka tanah tinggi.
“Gerakan Peduli Anak” Sebagai Upaya Pencegahan Prostitusi Anak di Kota Kendari
Authors: Hijriani Hijriani , Niasa La , Yusuf M. , Dewi Ayu Lestari , Alimuddin Alimuddin , Tahir Muh. , Supriadi Supriadi 
Published: December 2022

Maraknya peristiwa prostitusi di wilayah hukum Kota Kendari yang melibatkan gadis muda bahkan beberapa di antaranya masih di bawah umur menjadi perhatian serius atas praktik tindak pidana prostitusi. Tujuan dari pengabdian ini untuk memberikan kontribusi di dalam masyarakat baik secara teoritis maupun praktis dalam pencegahan maraknya prostitusi anak di Kota Kendari. Metode pendekatan yang digunakan adalah persuasif dan intensif, diawali dengan observasi, dilanjutkan dengan pertemuan formal dalam bentuk Dialog “Gerakan Peduli Anak”. Kegiatan ini dilaksanakan dengan metode interaktif, dialog yang diawali dengan tahap pemaparan materi, pendekatan analisis kasus, berbagi pengalaman, kemudian dilanjutkan pada tahap sharing, diskusi/tanya jawab, serta penguatan tujuan yang akan dicapai, agar tidak hanya menjadi bahan untuk dibaca dan didengarkan saja, tetapi diimplementasikan, dan ditindaklanjuti, agar meminimalisir terjadinya prostitusi terhadap perempuan dan anak.
Data and model bias in artificial intelligence for healthcare applications in New Zealand
Authors: Yogarajan Vithya , Dobbie Gillian , Leitch Sharon , Keegan Te Taka , Bensemann Joshua , Witbrock Michael , Asrani Varsha , Reith David 
Published: December 2022

IntroductionDevelopments in Artificial Intelligence (AI) are adopted widely in healthcare. However, the introduction and use of AI may come with biases and disparities, resulting in concerns about healthcare access and outcomes for underrepresented indigenous populations. In New Zealand, Māori experience significant inequities in health compared to the non-Indigenous population. This research explores equity concepts and fairness measures concerning AI for healthcare in New Zealand.MethodsThis research considers data and model bias in NZ-based electronic health records (EHRs). Two very distinct NZ datasets are used in this research, one obtained from one hospital and another from multiple GP practices, where clinicians obtain both datasets. To ensure research equality and fair inclusion of Māori, we combine expertise in Artificial Intelligence (AI), New Zealand clinical context, and te ao Māori. The mitigation of inequity needs to be addressed in data collection, model development, and model deployment. In this paper, we analyze data and algorithmic bias concerning data collection and model development, training and testing using health data collected by experts. We use fairness measures such as disparate impact scores, equal opportunities and equalized odds to analyze tabular data. Furthermore, token frequencies, statistical significance testing and fairness measures for word embeddings, such as WEAT and WEFE frameworks, are used to analyze bias in free-form medical text. The AI model predictions are also explained using SHAP and LIME.ResultsThis research analyzed fairness metrics for NZ EHRs while considering data and algorithmic bias. We show evidence of bias due to the changes made in algorithmic design. Furthermore, we observe unintentional bias due to the underlying pre-trained models used to represent text data. This research addresses some vital issues while opening up the need and opportunity for future research.DiscussionsThis research takes early steps toward developing a model of socially responsible and fair AI for New Zealand's population. We provided an overview of reproducible concepts that can be adopted toward any NZ population data. Furthermore, we discuss the gaps and future research avenues that will enable more focused development of fairness measures suitable for the New Zealand population's needs and social structure. One of the primary focuses of this research was ensuring fair inclusions. As such, we combine expertise in AI, clinical knowledge, and the representation of indigenous populations. This inclusion of experts will be vital moving forward, proving a stepping stone toward the integration of AI for better outcomes in healthcare.
Association of outcome with left ventricular volumes and ejection fraction measured with two- and three-dimensional echocardiography in patients referred for routine, clinically indicated studies
Authors: Muraru Denisa , Baldea Sorina Mihaila , Genovese Davide , Tomaselli Michele , Heilbron Francesca , Gavazzoni Mara , Radu Noela , Sergio Caravita , Baratto Claudia , Perelli Francesco , Curti Emanuele , Parati Gianfranco , Badano Luigi P. 
Published: December 2022

ObjectivesWe sought to analyze if left ventricular (LV) volumes and ejection fraction (EF) measured by three-dimensional echocardiography (3DE) have incremental prognostic value over measurements obtained from two-dimensional echocardiography (2DE) in patients referred to a high-volume echocardiography laboratory for routine, clinically-indicated studies.MethodsWe measured LV volumes and EF using both 2DE and 3DE in 725 consecutive patients (67% men; 59 ± 18 years) with various clinical indications referred for a routine clinical study.ResultsLV volumes were significantly larger, and EF was lower when measured by 3DE than 2DE. During follow-up (3.6 ± 1.2 years), 111 (15.3%) all-cause deaths and 248 (34.2%) cardiac hospitalizations occurred. Larger LV volumes and lower EF were associated with worse outcome independent of age, creatinine, hemoglobin, atrial fibrillation, and ischemic heart diseases). In stepwise Cox regression analyses, the associations of both death and cardiac hospitalization with clinical data (CD: age, creatinine, hemoglobin, atrial fibrillation, and ischemic heart disease) whose Harrel’s C-index (HC) was 0.775, were augmented more by the LV volumes and EF obtained by 3DE than by 2DE parameters. The association of CD with death was not affected by LV end-diastolic volume (EDV) either measured by 2DE or 3DE. Conversely, it was incremented by 3DE LVEF (HC = 0.84, p &lt; 0.001) more than 2DE LVEF (HC = 0.814, p &lt; 0.001). The association of CD with the composite endpoint (HC = 0.64, p = 0.002) was augmented more by 3DE LV EDV (HC = 0.786, p &lt; 0.001), end-systolic volume (HC = 0.801, p &lt; 0.001), and EF (HC = 0.84, p &lt; 0.001) than by the correspondent 2DE parameters (HC = 0.786, HC = 0.796, and 0.84, all p &lt; 0.001) In addition, partition values for mild, moderate and severe reduction of the LVEF measured by 3DE showed a higher discriminative power than those measured by 2DE for cardiac death (Log-Rank: χ2 = 98.3 vs. χ2 = 77.1; p &lt; 0.001). Finally, LV dilation defined according to the 3DE threshold values showed higher discriminatory power and prognostic value for death than when using 2DE reference values (3DE LVEDV: χ2 = 15.9, p &lt; 0.001 vs. χ2 = 10.8, p = 0.001; 3DE LVESV: χ2 = 24.4, p &lt; 0.001 vs. χ2 = 17.4, p = 0.001).ConclusionIn patients who underwent routine, clinically-indicated echocardiography, 3DE LVEF and ESV showed stronger association with outcome than the corresponding 2DE parameters.
Successful parathyroidectomy improves cognition in patients with primary hyperparathyroidism: A prospective study in a tertiary medical center and comprehensive review of the literature
Authors: Szalat Auryan , Tamir Noa , Mazeh Haggi , Newman J. P. 
Published: December 2022

ContextThe recent American and European guidelines on management of patients with primary hyperparathyroidism (PHPT) did not endorse neurocognitive evaluation as part of standard work-up and did not consider it as a surgery criterion.The neurocognitive deleterious effects of hyperparathyroidism and impact of parathyroidectomy on PHPT patients is yet to be elucidated.ObjectiveTo evaluate specific neurocognitive functions in PHPT patients prior to parathyroidectomy and describe the changes during follow-up with serial evaluations.DesignA prospective case-control study including parathyroidectomy candidates evaluated at a tertiary teaching university hospital. Thorough neurocognitive evaluation was conducted before and 1- &amp; 6-months following parathyroidectomy: Rey Auditory Verbal Learning Test (RAVLT), Rey-Osterrieth Complex Figure Test (ROCF), Trail Making Test A, Trail Making Test B, Addenbrooke’s Cognitive Examination-III (ACE), Frontal Assessment Battery (FAB), Beck Depression Inventory (BDI).Results18 consecutive patients underwent successful parathyroidectomy. Various neurocognitive functions improved significantly after successful parathyroidectomy: long term auditory memory (RAVLT, p=0.008), short- and long-term visual memory (ROCF, p=0.006 and p=0.002 respectively), visual attention and complex concentration skills (trail making A, p&lt;0.001) and executive abilities (trail making B, p=0.005). No change was identified in frontal-lobe abilities. Depression symptoms were absent or minimal prior to surgery and no significant change was observed after surgery.ConclusionsPHPT is associated with significant various neurocognitive dysfunctions when mindfully evaluated before surgery. Successful parathyroidectomy results in several neurocognitive aspect improvements. The data suggest that neurocognitive deterioration may be considered an added parathyroidectomy criterion when surgical decision is not straightforward.
Meta-analysis of TSH suppression therapy and the risk of cardiovascular events after thyroid cancer surgery
Authors: Yang Xiao , Guo Nan , Gao Xin , Liang Jiwang , Fan Xinlong , Zhao Yuejiao 
Published: December 2022

ObjectiveTo investigate the relationship between TSH suppression therapy and cardiovascular events in patients with thyroid cancer after surgery.MethodsPub Med, Web of Science, and Embase databases were retrieved to collect studies related to the risk of cardiovascular events in patients treated with TSH suppression after thyroid cancer surgery. RevMan statistical software was used for meta-analysis.ResultsA total of 14 studies were included. The mean heart rate of patients after thyroid cancer surgery was higher than that of the control group (SMD=2.59, 95% CI: -0.37,.54), and the risk of atrial fibrillation was increased compared with the control group (RR = 1.52, 95%CI, 1.28-1.81; I = 63%). Ejection fraction and left ventricular end-diastolic diameter were not significantly different between the two groups, ejection fraction SMD = -0.10, 95% CI: -3.73, 3.52, left ventricular end-diastolic diameter SMD = -0.09, 95% CI: - 1.29, 1.11. Patients with TSH suppression after thyroid cancer had higher mean systolic blood pressure than controls (SMD = 1.97, 95% CI: −1.09, 5.03) and mean diastolic blood pressure (SMD = 1.85, 95% CI: -0.15, 3.85).ConclusionMeta-analysis concluded that TSH suppression therapy after thyroid cancer surgery increases the risk of atrial fibrillation in patients. In addition, the heart rate, systolic blood pressure and diastolic blood pressure are higher than those in the control group, and there is no significant difference in ejection fraction and left ventricular end-diastolic diameter.
Prospective multicenter non-interventional real-world study to assess the patterns of use, effectiveness and safety of follitropin delta in routine clinical practice (the PROFILE study)
Authors: Blockeel Christophe , Griesinger Georg , Rago Rocco , Larsson Per , Sonderegger Yum Lina Yip , Rivière Stéphane , Laven Joop S. E. 
Published: December 2022

ObjectiveTo observe the real-world utilization patterns, effectiveness and safety profile of follitropin delta in women ≥18 years naïve to ovarian stimulation undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).DesignProspective, multinational, multicenter, observational study. All IVF/ICSI treatment protocols were conducted according to routine clinical practice, including undertaking fresh/frozen transfers. Outcomes included use of dosing algorithm, follitropin delta dosing patterns, ovarian response, pregnancy rates and adverse drug reactions (ADRs).ResultsThe first ovarian stimulation cycle using follitropin delta was initiated in 944 women. Mean baseline demographics were: age, 33.5 ± 4.7 years; bodyweight, 67.1 ± 13.6 kg; anti-Müllerian hormone, 20.3 ± 16.1 pmol/L (2.84 ± 2.25 ng/mL). The dosing algorithm was used to calculate the follitropin delta daily starting dose in 893/944 women (94.5%). The mean difference between the calculated and prescribed daily dose was small (0.2 ± 1.40 µg). The mean daily starting follitropin delta dose was 10.4 ± 2.72 µg and the mean total dose administered was 104 µg. Follitropin delta dose adjustments were reported for 57/944 (6.0%) women. The mean number of retrieved oocytes was 10.1 ± 7.03. Ongoing pregnancy at 10–11 weeks was reported for 255 women (27.0% per initiated cycle and 43.1% per fresh transfer [n=592]). Cumulative ongoing pregnancy rate after fresh and/or frozen transfer was 36.4% (344/944). Four women discontinued follitropin delta due to ADRs. Ovarian hyperstimulation syndrome (OHSS) was the most frequently reported ADR (n=37 [3.9%]); most cases of OHSS were of mild or moderate intensity (n=30 [3.2%]).ConclusionsThis large real-world study of follitropin delta utilization patterns confirms its good pregnancy rates while minimizing OHSS risk during first ovarian stimulation cycle.
AbAgIntPre: A deep learning method for predicting antibody-antigen interactions based on sequence information
Authors: Huang Yan , Zhang Ziding , Zhou Yuan 
Published: December 2022

IntroductionAntibody-mediated immunity is an essential part of the immune system in vertebrates. The ability to specifically bind to antigens allows antibodies to be widely used in the therapy of cancers and other critical diseases. A key step in antibody therapeutics is the experimental identification of antibody-antigen interactions, which is generally time-consuming, costly, and laborious. Although some computational methods have been proposed to screen potential antibodies, the dependence on 3D structures still limits the application of these methods.MethodsHere, we developed a deep learning-assisted prediction method (i.e., AbAgIntPre) for fast identification of antibody-antigen interactions that only relies on amino acid sequences. A Siamese-like convolutional neural network architecture was established with the amino acid composition encoding scheme for both antigens and antibodies.Results and DiscussionThe generic model of AbAgIntPre achieved satisfactory performance with the Area Under Curve (AUC) of 0.82 on a high-quality generic independent test dataset. Besides, this approach also showed competitive performance on the more specific SARS-CoV dataset. We expect that AbAgIntPre can serve as an important complement to traditional experimental methods for antibody screening and effectively reduce the workload of antibody design. The web server of AbAgIntPre is freely available at http://www.zzdlab.com/AbAgIntPre.
Monoclonal antibodies constructed from COVID-19 convalescent memory B cells exhibit potent binding activity to MERS-CoV spike S2 subunit and other human coronaviruses
Authors: Peng Yuan , Liu Yongcheng , Hu Yabin , Chang Fangfang , Wu Qian , Yang Jing , Chen Jun , Teng Shishan , Zhang Jian , He Rongzhang , Wei Youchuan , Bostina Mihnea , Luo Tingrong , Liu Wenpei , Qu Xiaowang , Li Yi-Ping 
Published: December 2022

IntroductionThe Middle East respiratory syndrome coronavirus (MERS-CoV) and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are two highly contagious coronaviruses causing MERS and COVID-19, respectively, without an effective antiviral drug and a long-lasting vaccine. Approaches for diagnosis, therapeutics, prevention, etc., particularly for SARS-CoV-2 that is continually spreading and evolving, are urgently needed. Our previous study discovered that &gt;60% of sera from convalescent COVID-19 individuals, but &lt;8% from general population, showed binding activity against the MERS-CoV spike protein, indicating that SARS-CoV-2 infection boosted antibodies cross-reactive with MERS-CoV.MethodsTo generate antibodies specific to both SARS-CoV-2 and MERS-CoV, here we screened 60 COVID-19 convalescent sera against MERS-CoV spike extracellular domain and S1 and S2 subunits. We constructed and characterized monoclonal antibodies (mAbs) from COVID-19 convalescent memory B cells and examined their binding and neutralizing activities against human coronaviruses.Results and DiscussionOf 60 convalescent serum samples, 34 showed binding activity against MERS-CoV S2, with endpoint titers positively correlated with the titers to SARS-CoV-2 S2. By sorting single memory B cells from COVID-19 convalescents, we constructed 38 mAbs and found that 11 mAbs showed binding activity with MERS-CoV S2, of which 9 mAbs showed potent cross-reactivity with all or a proportion of spike proteins of alphacoronaviruses (229E and NL63) and betacoronaviruses (SARS-CoV-1, SARS-CoV-2, OC43, and HKU1). Moreover, 5 mAbs also showed weak neutralization efficiency against MERS-CoV spike pseudovirus. Epitope analysis revealed that 3 and 8 mAbs bound to linear and conformational epitopes in MERS-CoV S2, respectively. In summary, we have constructed a panel of antibodies with broad-spectrum reactivity against all seven human coronaviruses, thus facilitating the development of diagnosis methods and vaccine design for multiple coronaviruses.
Variations in dynamic tumor-associated antigen-specific T cell responses correlate with HCC recurrence after thermal ablation
Authors: Zang Chaoran , Zhao Yan , Liu Guihai , Li Kang , Qin Ling , Zhang Yuewei , Sun Jianping , Wang Qi , Ma Liang , Zhao Peng , Sun Yu , Guo Dandan , Yuan Chunwang , Dong Tao , Zhang Yonghong 
Published: December 2022

BackgroundAblative therapy is a recommended treatment for hepatocellular carcinoma (HCC) not only for its effective eradication of tumors, but also for its induction of host immunity. However, the high 5-year recurrence rate after ablation underlines the poor understanding of the antitumor immunity response. Here, we investigated the effects of thermal ablation on antitumor immunity.MethodsWe analyzed the dynamics of tumor-associated antigen (TAA)-specific immune responses and changes in peripheral blood mononuclear cell phenotype in patients with HCC before and after tumor ablation. We used the IFN-γ ELISPOT assay and immunophenotyping by flow cytometry to evaluate the effects of ablation on host immunity. The correlation between the T cell response and disease outcome was explored to uncover the efficacy of the immune response in inhibiting HCC recurrence.ResultsDifferent TAA-specific T cell responses were identified among patients before and after ablation. One week after ablation, there was an improved immune state, with a switch from the dominance of an AFP-specific T cell response to that of a SMNMS-specific T cell response, which was correlated with better survival. Furthermore, an improvement in immune status was accompanied by a lower level of PD1+ and Tim3+ T cells in CD8+ T cells. Although this functional state was not durable, there was a higher degree of AFP-specific T cell responses at 4-weeks post-ablation. Furthermore, T cells presented a more exhausted phenotype at 4-weeks post-ablation than at the 1-week timepoint.ConclusionsAblation elicits a transient antitumor immune response in patients with HCC by changing the profile of the T cell response and the expression of immune checkpoint molecules, which correlated with longer recurrence-free survival of patients with HCC.