bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osseous variations associated with physiological thinning of the glenoid articular cartilage: an osteological study with CT, MRI and arthroscopic correlations
Authors: Benes Michal , Fulin Petr , Kachlik David , Al-Redouan Azzat , Tomaides Jan , Kysilko Martin , Salavova Sarka , Kunc Vojtech 
Published: May 2023

Abstract
Objective
To investigate the relationship between osseous variations of the glenoid fossa and thinning of the overlaying articular cartilage.

Materials and methods
In total, 360 dry scapulae, comprising adult, children and fetal specimens, were observed for potential presence of osseous variants inside the glenoid fossa. Subsequently, the appearance of the observed variants was evaluated using CT and MRI (each 300 scans), and in-time arthroscopic findings (20 procedures). New terminology of the observed variants was proposed by an expert panel formed by orthopaedic surgeons, anatomists and radiologists.

Results
Tubercle of Assaky was observed in 140 (46.7%) adult scapulae, and an innominate osseous depression was identified in 27 (9.0%) adult scapulae. Upon radiological imaging, the tubercle of Assaky was found in 128 (42.7%) CTs and 118 (39.3%) MRIs, while the depression was identified in 12 (4.0%) CTs and 14 (4.7%) MRIs. Articular cartilage above the osseous variations appeared relatively thinner and in several young individuals was found completely absent. Moreover, the tubercle of Assaky featured an increasing prevalence with aging, while the osseous depression develops in the second decade. Macroscopic articular cartilage thinning was identified in 11 (55.0%) arthroscopies. Consequently, four new terms were invented to describe the presented findings.

Conclusion
Physiological articular cartilage thinning occurs due to the presence of the intraglenoid tubercle or the glenoid fovea. In teenagers, the cartilage above the glenoid fovea may be naturally absent. Screening for these variations increases the diagnostic accuracy of glenoid defects. In addition, implementing the proposed terminological updates would optimize communication accuracy.
Number of days required to measure sedentary time and physical activity using accelerometery in rheumatoid arthritis: a reliability study
Authors: O’Brien Ciara M. , Kitas George D. , Rayner Fiona , Isaacs John D. , Baker Kenneth F. , Pratt Arthur G. , Buckley Christopher D. , Raza Karim , Filer Andrew , Siebert Stefan , McInnes Iain , McGucken Andrew , Fenton Sally A. M. ,   The BIOFLARE Consortium
Published: May 2023

AbstractThis study aimed to determine the minimum number of days required to reliably estimate free-living sedentary time, light-intensity physical activity (LPA) and moderate-intensity physical activity (MPA) using accelerometer data in people with Rheumatoid Arthritis (RA), according to Disease Activity Score-28-C-reactive protein (DAS-28-CRP). Secondary analysis of two existing RA cohorts with controlled (cohort 1) and active (cohort 2) disease was undertaken. People with RA were classified as being in remission (DAS-28-CRP < 2.4,n = 9), or with low (DAS-28-CRP ≥ 2.4—≤ 3.2,n = 15), moderate (DAS-28-CRP > 3.2—≤ 5.1,n = 41) or high (DAS-28-CRP > 5.1,n = 16) disease activity. Participants wore an ActiGraph accelerometer on their right hip for 7 days during waking hours. Validated RA-specific cut-points were applied to accelerometer data to estimate free-living sedentary time, LPA and MPA (%/day). Single-day intraclass correlation coefficients (ICC) were calculated and used in the Spearman Brown prophecy formula to determine the number of monitoring days required to achieve measurement reliability (ICC ≥ 0.80) for each group. The remission group required ≥ 4 monitoring days to achieve an ICC ≥ 0.80 for sedentary time and LPA, with low, moderate and high disease activity groups requiring ≥ 3 monitoring days to reliably estimate these behaviours. The monitoring days required for MPA were more variable across disease activity groups (remission =  ≥ 3 days; low =  ≥ 2 days; moderate =  ≥ 3 days; high =  ≥ 5 days). We conclude at least 4 monitoring days will reliably estimate sedentary time and LPA in RA, across the whole spectrum of disease activity. However, to reliably estimate behaviours across the movement continuum (sedentary time, LPA, MPA), at least 5 monitoring days are required.
Observed and projected changes in snow accumulation and snowline in California’s snowy mountains
Authors: Shulgina Tamara , Gershunov Alexander , Hatchett Benjamin J. , Guirguis Kristen , Subramanian Aneesh C. , Margulis Steven A. , Fang Yiwen , Cayan Daniel R. , Pierce David W. , Dettinger Michael , Anderson Michael L. , Ralph F. Martin 
Published: May 2023

AbstractThe Sierra Nevada and Southern Cascades—California’s snowy mountains—are primary freshwater sources and natural reservoirs for the states of California and Nevada. These mountains receive precipitation overwhelmingly from wintertime storms including atmospheric rivers (ARs), much of it falling as snow at the higher elevations. Using a seven-decade record of daily observed temperature and precipitation as well as a snow reanalysis and downscaled climate projections, we documented historical and future changes in snow accumulation and snowlines. In four key subregions of California’s snowy mountains, we quantified the progressing contribution of ARs and non-AR storms to the evolving and projected snow accumulation and snowlines (elevation of the snow-to-rain transition), exploring their climatology, variability and trends. Historically, snow makes up roughly a third of the precipitation affecting California’s mountains. While ARs make up only a quarter of all precipitating days and, due to their relative warmth, produce snowlines higher than do other storms, they contribute over 40% of the total seasonal snow. Under projected unabated warming, snow accumulation would decline to less than half of historical by the late twenty-first century, with the greatest snow loss at mid elevations (from 1500 to 3300 m by the mountain sub-regions) during fall and spring. Central and Southern Sierra Nevada peaks above 3400 m might see occasionally extreme snow accumulations in January–February resulting entirely from wetter ARs. AR-related snowlines are projected to increase by more than 700 m, compared to about 500 m for other storms. We discuss likely impacts of the changing climate for water resources as well as for winter recreation.
Yield of brain MRI in children with autism spectrum disorder
Authors: Byrne D , Fisher A , Baker L , Twomey EL , Gorman K M 
Published: May 2023

AbstractAutism spectrum disorder (ASD) is a common neurodevelopmental condition. The American Academy of Paediatrics and American Academy of Neurology do not recommend routine brain magnetic resonance imaging (MRI) in the assessment of ASD. The need for a brain MRI should be decided on atypical features in the clinical history and examination. However, many physicians continue to use brain MRI routinely in the assessment process. We performed a retrospective review of indications for requesting brain MRI in our institution over a 5-year period. The aim was to identify the yield of MRI in children with ASD and calculate the prevalence of significant neuroimaging abnormalities in children with ASD and identify clinical indications for neuroimaging. One hundred eighty-one participants were analysed. An abnormal brain MRI was identified in 7.2% (13/181). Abnormal brain MRI was more likely with an abnormal neurological examination (OR 33.1, p = 0.001) or genetic/metabolic abnormality (OR 20, p = 0.02). In contrast, abnormal MRI was not shown to be more likely in children with a variety of other indications such as behavioural issues and developmental delay. Conclusion: Thus, our findings support that MRI should not be a routine investigation in ASD, without additional findings. The decision to arrange brain MRI should be made on a case-by-case basis following careful evaluation of potential risks and benefits. The impact of any findings on the management course of the child should be considered prior to arranging imaging.

What is Known:• Incidental brain MRI findings are common in children with and without ASD.• Many children with ASD undergo brain MRI in the absence of neurological comorbidities.

What is New:• Brain MRI abnormalities in ASD are more likely with an abnormal neurological examination and genetic or metabolic conditions.• Prevalence of significant brain MRI abnormalities in ASD alone is low.
Intrarenal renin–angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis
Authors: Hattori Tomoki , Fujioka Keisuke , Nagai Takashi , Kondo Shuji , Kagami Shoji , Hirayama Masahiro , Urushihara Maki 
Published: May 2023

Abstract

Background
The current study tested the hypothesis that urinary angiotensinogen (UAGT) and urinary monocyte chemoattractant protein-1 (UMCP-1) levels provide a specific index of intrarenal renin–angiotensin system (RAS) status and the degree of infiltration of macrophages associated with RAS blockade and immunosuppressant treatment in pediatric patients with chronic glomerulonephritis.

Methods
We measured baseline UAGT and UMCP-1 levels to examine the correlation between glomerular injury in 48 pediatric chronic glomerulonephritis patients before treatment. Furthermore, we performed immunohistochemical analysis of angiotensinogen (AGT) and CD68 in 27 pediatric chronic glomerulonephritis patients treated with RAS blockades and immunosuppressants for 2 years. Finally, we examined the effects of angiotensin II (Ang II) on monocyte chemoattractant protein-1 (MCP-1) expression in cultured human mesangial cells (MCs).

Results
Baseline UAGT and UMCP-1 levels positively correlated with urinary protein levels, scores for mesangial hypercellularity, rate of crescentic formation, and expression levels of AGT and CD68 in renal tissues (p < 0.05). UAGT and UMCP-1 levels were significantly decreased after RAS blockade and immunosuppressant treatment (p < 0.01), which was accompanied by AGT and CD68 (p < 0.01), as well as the magnitude of glomerular injury. Cultured human MCs showed increased MCP-1 messenger ribonucleic acid and protein levels after Ang II treatment (p < 0.01).

Conclusions
The data indicates that UAGT and UMCP-1 are useful biomarkers of the degree of glomerular injury during RAS blockade and immunosuppressant treatment in pediatric patients with chronic glomerulonephritis.
Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization
Authors: Jiang Keqing , Lu Shibang , Li Dongxiao , Liu Mingjiang , Jin Hu , Lei Biao , Wang Sifan , Long Kang , He Songqing , Zhong Fudi 
Published: May 2023

Abstract
Background
Nonalcoholic steatohepatitis (NASH) is an advanced form of chronic fatty liver disease, which is a driver of hepatocellular carcinoma. However, the roles of the C5aR1 in the NASH remain poorly understood. Here, we aimed to investigate the functions and mechanisms of the C5aR1 on hepatic inflammation and fibrosis in murine NASH model.

Methods
Mice were fed a normal chow diet with corn oil (ND + Oil), a Western diet with corn oil (WD + Oil) or a Western diet with carbon tetrachloride (WD + CCl4) for 12 weeks. The effects of the C5a–C5aR1 axis on the progression of NASH were analyzed and the underlying mechanisms were explored.

Results
Complement factor C5a was elevated in NASH mice. C5 deficiency reduced hepatic lipid droplet accumulation in the NASH mice. The hepatic expression levels of TNFα, IL-1β and F4/80 were decreased in C5-deficient mice. C5 loss alleviated hepatic fibrosis and downregulated the expression levels of α-SMA and TGFβ1. C5aR1 deletion reduced inflammation and fibrosis in NASH mice. Transcriptional profiling of liver tissues and KEGG pathway analysis revealed that several pathways such as Toll-like receptor signaling, NFκB signaling, TNF signaling, and NOD-like receptor signaling pathway were enriched between C5aR1 deficiency and wild-type mice. Mechanistically, C5aR1 deletion decreased the expression of TLR4 and NLRP3, subsequently regulating macrophage polarization. Moreover, C5aR1 antagonist PMX-53 treatment mitigated the progression of NASH in mice.

Conclusions
Blockade of the C5a–C5aR1 axis reduces hepatic steatosis, inflammation, and fibrosis in NASH mice. Our data suggest that C5aR1 may be a potential target for drug development and therapeutic intervention of NASH.
Lumbar puncture-verified subarachnoid hemorrhage: bleeding sources, need of radiological examination, and functional recovery
Authors: Kevci Rozerin , Lewén Anders , Ronne-Engström Elisabeth , Velle Fartein , Enblad Per , Svedung Wettervik Teodor 
Published: May 2023

Abstract
Background
The primary aim was to determine the diagnostic yield of vascular work-up, the clinical course during neurointensive care (NIC), and rate of functional recovery for patients with computed tomography (CT)-negative, lumbar puncture (LP)-verified SAH.

Methods
In this retrospective study, 1280 patients with spontaneous SAH, treated at our NIC unit, Uppsala University Hospital, Sweden, between 2008 and 2018, were included. Demography, admission status, radiological examinations (CT angiography (CTA) and digital subtraction angiography (DSA)), treatments, and functional outcome (GOS-E) at 12 months were evaluated.

Results
Eighty (6%) out of 1280 SAH patients were computed tomography (CT)-negative, LP-verified cases. Time between ictus and diagnosis was longer for the LP-verified SAH cohort in comparison to the CT-positive patients (median 3 vs 0 days, p < 0.001). One fifth of the LP-verified SAH patients exhibited an underlying vascular pathology (aneurysm/AVM), which was significantly less common than for the CT-verified SAH cohort (19% vs. 76%, p < 0.001). The CTA- and DSA-findings were consistent in all of the LP-verified cases. The LP-verified SAH patients exhibited a lower rate of delayed ischemic neurological deficits, but no difference in rebleeding rate, compared to the CT-verified cohort. At 1-year post-ictus, 89% of the LP-verified SAH patients had recovered favorably, but 45% of the cases did not reach good recovery. Having an underlying vascular pathology and an external ventricular drainage were associated with worse functional recovery (p = 0.02) in this cohort.

Conclusions
LP-verified SAH constituted a small proportion of the entire SAH population. Having an underlying vascular pathology was less frequent in this cohort, but still occurred in one out of five patients. Despite the small initial bleeding in the LP-verified cohort, many of these patients did not reach good recovery at 1 year, this calls for more attentive follow-up and rehabilitation in this cohort.
The ‘α-synucleinopathy syndicate’: multiple system atrophy and Parkinson’s disease
Authors: Sian-Hulsmann Jeswinder , Riederer Peter 
Published: May 2023

AbstractMultiple System Atrophy (MSA) and Parkinson’s diseases (PD) are elite members of the α-synucleinopathy organization. Aberrant accumulations of the protein α-synuclein characterize them. A plethora of evidence indicates the involvement of these rogue inclusions in a cascade of events that disturb cellular homeostasis resulting in neuronal dysfunction. These two neurodegenerative diseases share many features both clinically and pathologically. Cytotoxic processes commonly induced by reactive free radical species have been associated with oxidative stress and neuroinflammation, frequently reported in both diseases. However, it appears they have characteristic and distinct α-synuclein inclusions. It is glial cytoplasmic inclusions in the case of MSA while Lewy bodies manifest in PD. This is probably related to the etiology of the illness. At present, precise mechanism(s) underlying the characteristic configuration of neurodegeneration are unclear. Furthermore, the “prion-like” transmission from cell to cell prompts the suggestion that perhaps these α-synucleinopathies are prion-like diseases. The possibility of some underlying genetic foul play remains controversial. But as major culprits of pathological processes or even single triggers of PD and MSA are the same—like oxidative stress, iron-induced pathology, mitochondriopathy, loss of respiratory activity, loss of proteasomal function, microglial activation, neuroinflammation—it is not farfetched to assume that in sporadic PD and also in MSA a variety of combinations of susceptibility genes contribute to the regional specificity of pathological onset. These players of pathology, as mentioned above, in a synergistic combination, are responsible for driving the progression of PD, MSA and other neurodegenerative disorders. Elucidating the triggers and progression factors is vital for advocating disease modification or halting its progression in both, MSA and PD.
Rainfall changes perceived by farmers and captured by meteorological data: two sides to every story
Authors: Hubertus Lena , Groth Juliane , Teucher Mike , Hermans Kathleen 
Published: May 2023

AbstractSubsistence farmers with high dependency on natural resources are exceptionally vulnerable to rainfall changes. Besides, they are in the front row when it comes to observing these changes. Studies that systematically investigate similarities and differences between measured and perceived rainfall changes are typically limited to trends in rainfall amounts, thereby disregarding changes in extreme events, rainy season durations, and timing. We address this gap by contrasting rainfall changes perceived by subsistence farmers in the Ethiopian highlands with meteorological daily rainfall data derived from the Climate Hazards Group Infrared Precipitation with Stations (CHIRPS). We applied nine distinct metrics for rainfall dynamics, accounting for rainfall variability, including extreme events and changes in the onset and cessation of the two rainy seasons. Farmers perceived increasingly unreliable rainfall for both the short and the long rainy seasons, with later onset and earlier cessation, increasing rainfall intensity, and increasing occurrence of untimely rainfall and droughts. This partially disagrees with the CHIRPS data that indicate most significant rainfall changes for the short rainy season only. Since the early 1980s, this season has been experiencing decreasing rainfall amounts, with high variability between years and an increasingly uncertain – yet delayed – onset. In contrast, the long rainy season experienced little changes in rainfall. Our results point towards changing farmers' water availability and water demand as an explanation for the perceived deteriorating rainfall conditions. As farmers’ perceptions partly diverge from meteorological observations, both data sources should be used complementarily to improve our understanding of climatic change.
RETRACTED ARTICLE: Circular RNA circDLG1 contributes to HCC progression by regulating the miR-141-3p/WTAP axis
Authors: Wang Qian , Yu Wei , Wang Tao , Huang Changshan 
Published: May 2023

AbstractThis study aims to explore novel and reliable biomarkers for predicting hepatocellular carcinoma (HCC) prognosis. Circular RNAs (circRNAs) were determined by analysis of human circRNA arrays and quantitative reverse transcription polymerase reactions. To test for an interaction between circDLG1, we used luciferase reporter assays, RNA immunoprecipitation, and fluorescence in situ hybridization assays that were employed to test the interaction between circDLG1, miR-141-3p, and WTAP. q-RT-PCR and western blot were used to evaluate the target regulation of miR-141-3p and WTAP. shRNA-mediated knockdown of circDLG1, proliferation, migration, and invasion experiment of metastasis were used to evaluate the function of circDLG. CircDLG1 rather than lining DLG1 was upregulated in HCC tissues, from HCC patients as well as HCC cell lines compared to normal controls. circDLG1 high expression in HCC patients was correlated with shorter overall survival. Knockdown of circDLG1 and miR-141-3p mimic could inhibit the tumorigenesis of HCC cells in vivo and in vitro. Importantly, we demonstrated that circDLG1 could act as a sponge of miR-141-3p to regulate the expression of WTAP, and further suppress the tumorigenesis of HCC cells. Our study reveals that circDLG1 can serve as a novel potential circulating biomarker for the detection of HCC. circDLG1 participates in the progression of HCC cells by sponging miR-141-3p with WTAP, providing new insight into the treatment of HCC.
The effects of mindfulness-based interventions in medical students: a systematic review
Authors: Kaisti Ilona , Kulmala Petri , Hintsanen Mirka , Hurtig Tuula , Repo Saara , Paunio Tiina , Miettunen Jouko , Halt Anu-Helmi , Jääskeläinen Erika 
Published: May 2023

AbstractThe number of studies on the effects of mindfulness on healthcare professionals is increasing. The main aim of this study was to collate the quantitative results of original studies analyzing the effects of mindfulness-based interventions on a variety of outcomes in medical students. We also analyzed how the study design and characteristics of the intervention affect the results, and identified qualitative effects of mindfulness interventions. A literature search was performed in different databases in June 2020. Original articles meeting the following criteria were included: (1) at least 50% of the participants were medical students, (2) included a mindfulness intervention, (3) analyzed any outcome relating to mindfulness intervention, (4) peer-reviewed (5) written in English. Eventually, 31 articles including 24 different samples were included. Over half of the studies were RCTs. In over half of the studies, the intervention was 4- to 10-week original Mindfulness-Based Stress Reduction or Mindfulness-Based Cognitive Therapy or a modification of these. In general, satisfaction with the interventions was good. Based on a meta-analysis, after the intervention, the intervention group had statistically significantly fewer symptoms of stress and distress and had higher mindfulness than the controls. The beneficial effects persisted in follow-ups over months or years. Both long and shorter courses and courses with and without face-to-face sessions were effective. Both controlled and uncontrolled studies had statistically significant results. Qualitative results revealed potential factors behind the quantitative effects. The number of studies on mindfulness interventions in medical students has increased drastically. Mindfulness-based interventions seem to offer a good possibility to enhance medical students’ well-being.
Is Biofeedback for Vertigo Effective in Ordinary Medical Centers? A Controlled Trial in Northern Italy
Authors: Buizza Chiara , Franco Elena , Ghilardi Alberto 
Published: May 2023

AbstractThe aim of this study was to assess the therapeutic effectiveness of biofeedback, in a medical center’s routine for treating vestibular disorders, reducing emotional, functional, and physical disability at three-month follow-up. A total of 197 outpatients were recruited from a medical center to treat vestibular disorders. Patients in the control group received treatment as usual, consisting of one monthly visit with an otolaryngologist and pharmacological treatment specific for vertigo, while the experimental group attended biofeedback training. Patients in the experimental group received pharmacological therapy only in the phase before the start of biofeedback in order to stabilize the acute phase. During the three-month follow-up, the experimental group did not receive any booster sessions of biofeedback. At three-month follow-up there was a statistically significant difference between the groups, both in the mean total score of the dizziness handicap inventory and in the three subscales: physical, emotional, and functional. Moreover, the biofeedback group had reduced psycho-physiological parameters for all average values at three-month follow-up compared to the baseline. This is one of few studies assessing the effectiveness of biofeedback in a naturalistic setting for vestibular disorder treatment. The data confirmed that biofeedback can impact illness course, in terms of self-perceived disability reduction, assessed on emotional, functional, and physical aspects of daily living.