bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, attitudes, and practice related to the prone positioning of patients among intensive care unit nurses working in COVID‐19 units: A cross‐sectional study in China
Authors: Chen Xiuwen , Zhou Yang , Zhou Xia , Su Pan , Yi Jindong 
Published: April 2023

AbstractBackgroundAn increasing number of studies persistently demonstrate that prone position ventilation can significantly improve the oxygenation index and blood oxygen saturation for most patients (70–80%) with acute respiratory distress syndrome (ARDS). Studies have also shown that the awake prone position was both safe and effective in helping patients with coronavirus disease 2019 (COVID‐19) breathe spontaneously. However, the prone position is not widely adopted when treating patients with COVID‐19 or ARDS from other causes. Basic knowledge, positive attitudes, and correct practices among the nursing staff are necessary to increase the use of prone positions, reduce the incidence of complications associated with prone positions, and improve the quality and safety of health care.AimThis study aimed to investigate the knowledge, attitudes, and practice of prone positioning of patients among intensive care unit (ICU) nurses working in COVID‐19 units and provide suggestions for improvement.Study designICU nurses were recruited from two designated tertiary hospitals for COVID‐19 treatment in Shanghai, China, in April 2022, using convenience sampling. A questionnaire survey focusing on the dimensions of knowledge, attitudes, and practice of the prone position with 42 items, was conducted.ResultsA total of 132 ICU nurses participated. The scores on the overall questionnaire and the dimensions of knowledge, attitudes, and practice of prone position were 167.28 (95% CI, 161.70–172.86), 78.35 (95% CI, 76.04–80.66), 32.08 (95% CI, 31.51–32.65), and 56.85 (95% CI, 52.42–61.28) respectively. The overall average score was 79.66% (95% CI, 0.77–0.82). The results of multiple linear regression analysis showed that prior experience in treating patients with COVID‐19 and professional titles were related to the level of knowledge, attitudes, and practice of prone position.ConclusionsThe ICU nurses strongly believed in the effectiveness of prone positioning, but their knowledge and practice levels need improvement. The experience in treating patients with COVID‐19 and professional titles were related to the level of knowledge, attitudes, and practice of prone position. Nursing managers should ensure that ICU nurses are well trained in prone positioning and help enhance the knowledge and attitudes toward prone positioning to promote its widespread use.Relevance to clinical practiceClinical guidelines and in‐service training modules need to be developed to promote the use of prone positioning and reduce prone position‐related complications.
Medical students' knowledge and perception of irritable bowel syndrome in comparison to inflammatory bowel disease
Authors: Henick Daniel , Italiano Tyler , Person Hannibal , Keefer Laurie 
Published: April 2023

AbstractBackgroundGastroenterologists may hold less positive attitudes toward disorders of gut–brain interaction (DGBI) like irritable bowel syndrome (IBS) compared with organic GI disorders like inflammatory bowel disease (IBD). This contributes to worse health outcomes in patients with DGBI and decreased patient satisfaction. Medical student knowledge and perception of these two disorders have not been directly studied.MethodsA cohort of medical students (n = 106) completed a survey where they read clinical vignettes about patients with IBS and IBD and answered questions regarding their knowledge of and attitudes toward these two diseases.Key resultsIBS was perceived as a less real and a more exaggerated disorder when compared to IBD, and patients with IBS were seen as more difficult to treat. With more clinical exposure across 4 years of training, students were more likely to perceive IBS as a “less real” illness, though they held fewer negative attitudes toward patients with IBS. Greater familiarity with both IBS and IBD was associated with fewer negative attitudes.Conclusions & InferencesBiases observed in gastroenterologists toward patients with IBS originate as early as the beginning of medical school, including seeing IBS as a “less real” disease and more difficult to treat. Earlier educational interventions may be helpful in identifying and addressing these biases.
Estimating the Radiance in Atmosphere-Ocean Systems With Different Atmosphere Models by Discrete Spherical Harmonics Method
Authors: Fokou Arantes , Tchinda Réné , Lambou Ymeli Guillaume , Lazard Myriam , Wang Cun-Hai 
Published: April 2023

Abstract
The radiative transfer in atmosphere-ocean systems with different atmosphere models is evaluated by the discrete spherical harmonics method. Four standard atmosphere models, namely, Tropical, Mid-Latitude Summer, Mid-Latitude Winter, and U.S. Standard (1976) limited to a height of 16 km are considered above an ocean. Two monochromatic radiations are considered according to the preponderance of the interaction they present with the participating medium, namely, λ=0.55 μm for scattering by particles and λ=16.8 μm for absorption and emission by water vapor and carbon dioxide. The absorption by the atmospheric gases considered is analyzed by the statistical narrow-band correlated-k method. The optical properties of aerosols and water clouds considered are calculated by Lorenz-Mie theory. The results obtained by the proposed discrete spherical harmonics method are in agreement with those of the literature and demonstrate the efficiency and accuracy of the developed radiative transfer code. The effects of the governing parameters of the system are investigated and show that the presence of the ocean contributes to increasing the upward radiation fluxes in the atmosphere. The presence of aerosols in the atmosphere leads to downward radiance curves at ground level that show significant peaks around the zenith angle of observation θ=0 deg. Additionally, the presence of the cloud in the atmosphere creates a discontinuity in the radiation flux curves at the height of the cloud.
Evidence-Theory-Based Reliability Analysis From the Perspective of Focal Element Classification Using Deep Learning Approach
Authors: Chen L. , Zhang Z. , Yang G. , Zhou Q. , Xia Y. , Jiang C. 
Published: April 2023

Abstract
Epistemic uncertainty is widespread in reliability analysis of practical engineering products. Evidence theory is regarded as a powerful model for quantifying and analyzing epistemic uncertainty. However, the heavy computational burden has severely hindered its application in practical engineering problems, which is essentially caused by the repeated extreme analysis of limit-state function (LSF). In order to address the issue, this paper proposes a novel method to solve the evidence-theory-based reliability analysis (ETRA). It transforms the conventional ETRA problem into the classification of three classes of joint focal elements (JFEs) and then solves the classification problem effectively through a deep learning approach. The core of solving an ETRA problem is to determine whether the joint focal element is located in the reliable region, failure region, or intersected with the LSF. A spatial position feature reduction and arrangement method is proposed to classify the JFEs, which can effectively reduce the feature dimension and take into account the integrity and correlation of features. The stacked autoencoders model is then constructed and updated by extracting the spatial position features of the sampled JFEs to achieve high-accuracy classification of the remaining JFEs, and the reliability interval is calculated efficiently according to the classification results. Finally, the effectiveness of the proposed method is demonstrated using several numerical examples.
Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Authors: Xiong Zhewen , Chan Stephen Lam , Zhou Jingying , Vong Joaquim S.L. , Kwong Tsz Tung , Zeng Xuezhen , Wu Haoran , Cao Jianquan , Tu Yalin , Feng Yu , Yang Weiqin , Wong Patrick Pak-Chun , Si-Tou Willis Wai-Yiu , Liu Xiaoyu , Wang Jing , Tang Wenshu , Liang Zhixian , Lu Jiahuan , Li Ka Man , Low Jie-Ting , Chan Michael Wing-Yan , Leung Howard H.W. , Chan Anthony W.H. , To Ka-Fai , Yip Kevin Yuk-Lap , Lo Yuk Ming Dennis , Sung Joseph Jao-Yiu , Cheng Alfred Sze-Lok 
Published: April 2023

ObjectiveTherapy-induced tumour microenvironment (TME) remodelling poses a major hurdle for cancer cure. As the majority of patients with hepatocellular carcinoma (HCC) exhibits primary or acquired resistance to antiprogrammed cell death (ligand)-1 (anti-PD-[L]1) therapies, we aimed to investigate the mechanisms underlying tumour adaptation to immune-checkpoint targeting.DesignTwo immunotherapy-resistant HCC models were generated by serial orthotopic implantation of HCC cells through anti-PD-L1-treated syngeneic, immunocompetent mice and interrogated by single-cell RNA sequencing (scRNA-seq), genomic and immune profiling. Key signalling pathway was investigated by lentiviral-mediated knockdown and pharmacological inhibition, and further verified by scRNA-seq analysis of HCC tumour biopsies from a phase II trial of pembrolizumab (NCT03419481).ResultsAnti-PD-L1-resistant tumours grew >10-fold larger than parental tumours in immunocompetent but not immunocompromised mice without overt genetic changes, which were accompanied by intratumoral accumulation of myeloid-derived suppressor cells (MDSC), cytotoxic to exhausted CD8+T cell conversion and exclusion. Mechanistically, tumour cell-intrinsic upregulation of peroxisome proliferator-activated receptor-gamma (PPARγ) transcriptionally activated vascular endothelial growth factor-A (VEGF-A) production to drive MDSC expansion and CD8+T cell dysfunction. A selective PPARγ antagonist triggered an immune suppressive-to-stimulatory TME conversion and resensitised tumours to anti-PD-L1 therapy in orthotopic and spontaneous HCC models. Importantly, 40% (6/15) of patients with HCC resistant to pembrolizumab exhibited tumorous PPARγ induction. Moreover, higher baseline PPARγ expression was associated with poorer survival of anti-PD-(L)1-treated patients in multiple cancer types.ConclusionWe uncover an adaptive transcriptional programme by which tumour cells evade immune-checkpoint targeting via PPARγ/VEGF-A-mediated TME immunosuppression, thus providing a strategy for counteracting immunotherapeutic resistance in HCC.
An Analysis of the Indo-Pacific Economic Framework (IPEF): Essence, Impacts and Prospects
Authors: Jiang Fangfei 
Published: April 2023

The Indo-Pacific Economic Framework (IPEF) proposed by the Biden administration has gone through three major stages — conception, preparation and engagement, and initial negotiation — and focuses on four key pillars: Connected Economy, Resilient Economy, Clean Economy, and Fair Economy. In fact, this initiative supplements and reinforces the Trump administration’s Indo-Pacific Strategy, while carrying forward and advancing the “America First” policy. It is a new attempt of the US to build an economic club exclusive of China in the Indo-Pacific and to lead in building a new structure for regional cooperation, as well as a diplomatic signal deliberately released by the Biden administration to its Eurasian allies during the Russia–Ukarine conflict. As the prospects of the IPEF are still of much uncertainty, it might exert few substantial impacts on China in the short term. However, we should still be alert to its long-term adverse influence on China–US relations, China’s surrounding international environment and foreign relations, the development of regional economic cooperation and world economy, as well as the stability of international order. Given the domestic situation in the US and the attitude of the other members, the progress of IPEF negotiations in the four pillars may vary significantly in the coming period.
Abstract 3878: Targeting Hippo-YAP, BRD4 and RAS-MAPK interplay in lung cancer to forestall drug resistance
Authors: Chatterjee Nilanjana , Olivas Victor , Wu Wei , Powell Ben , Bivona Trever 
Published: April 2023

Abstract
Introduction: Identifying parallel survival pathways or compensatory mechanisms that limit the response to targeted therapy is critical to discover effective combinatorial strategies for the treatment of lung cancer and to prevent emergence of drug resistance
Results: Using combination drug screening in a panel of cell line models of non-small cell lung cancer (NSCLC), we identified the tumor suppressor STK11 (aka LKB1) as a molecular biomarker of sensitivity to BET and RAS-MAPK pathway inhibitors combination in NSCLC. We found a small molecule inhibitor of BET (bromodomain and extra terminal) family proteins (BRD4, 3, 2), PLX51107, suppressed BRAF and KRAS mutant NSCLC cell proliferation and in combination with RAS (KRAS G12C), RAF or MEK inhibitor led to pronounced loss in cell viability with potent MYC downregulation and synergistic apoptosis induction in vitro and potent tumor regression or stasis in vivo in several KRAS mutant CDX and PDX mouse models of NSCLC. However, BRAF and KRAS mutant NSCLC cells with co-occurring mutations in STK11 were resistant to BET and RAS, RAF or MEK co-inhibition. To unravel the underlying mechanism of resistance to BET and RAS-MAPK inhibitors upon STK11 loss we modeled STK11 deficiency in BRAF and KRAS mutant NSCLC cells and tumors. We found that STK11 loss creates an unprecedented dependence on YAP/TEAD TFs. STK11 silencing in BRAF and KRAS mutant NSCLC cells resulted in nuclear transfer/activation of the HIPPO pathway effector, YAP, upregulation of the YAP target BIRC5 (aka Survivin) and rescued the synthetic lethality due to BET and RAS, RAF or MEK co-inhibition. Phenocopying STK11 loss, constitutively active YAP (YAP5SA), but not transcriptionally inactive YAP (YAPS94A), mitigated the deleterious effects of BET and RAS, RAF or MEK co-suppression in BRAF and KRAS mutant NSCLC cells with potent upregulation of the pro-survival factor BIRC5. Conversely, we found that co-silencing YAP or TEADs with BETs re-sensitized BRAF and KRAS mutant NSCLC cells with co-occurring mutations in STK11 to BET and RAS-MAPK inhibitors combination and caused synthetic lethality.
Conclusion: This study uncovered a functional interaction between BET proteins, STK11, HIPPO-YAP and RAS-MAPK signaling pathways in lung cancer. These results will help identify combinatorial strategies for treating aberrant RAS-MAPK pathway driven lung cancer more effectively and forestall drug resistance.
Citation Format: Nilanjana Chatterjee, Victor Olivas, Wei Wu, Ben Powell, Trever Bivona. Targeting Hippo-YAP, BRD4 and RAS-MAPK interplay in lung cancer to forestall drug resistance. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3878.
Abstract 705: Potentiation of immunotherapy by LSD1 modulation
Authors: Emond Wei B. , Sawant Rajiv , Geitmann Matthis , Winquist Johan , Brandt Peter , Bremberg Ulf , Källblad Per , Parrow Vendela , Andersson Claes , Blom Kristin , Najafi Nasrin , Bergström Tobias , Swartling Fredrik J. , Hellström Mats , Koehler Konrad F. 
Published: April 2023

Abstract
LSD1 has emerged as a potential therapeutic target to increase the effectiveness of cancer immunotherapy. We have developed a series of novel small molecules, exemplified by the lead substance BEA-17, that modulates LSD1 via binding to an allosteric site, without directly inhibiting its enzymatic activity. In cells, BEA-17 induces a reduction of LSD1 levels. In addition, BEA-17 upregulates the expression of endogenous retroviral genes and T cell-attractant chemokines and does so in an LSD1-dependent manner. In a co-culture of HeLa and PBMCs, BEA-17 increases cell kill of cancer cells by immune effector T cells, also in an LSD1-dependent manner. In a CT26 syngeneic animal model of colon cancer, BEA-17 potentiates the activity of anti-PD1 inhibitors. Finally, in a syngeneic GL261 animal model of glioblastoma, BEA-17 increases the effectiveness of standard-of-care temozolomide + radiation.
Citation Format: Wei B. Emond, Rajiv Sawant, Matthis Geitmann, Johan Winquist, Peter Brandt, Ulf Bremberg, Per Källblad, Vendela Parrow, Claes Andersson, Kristin Blom, Nasrin Najafi, Tobias Bergström, Fredrik J. Swartling, Mats Hellström, Konrad F. Koehler. Potentiation of immunotherapy by LSD1 modulation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 705.
Thomas Ebendorfer on virtus sermonis and the Relation between Theology, Philosophy, and Logic
Authors: Curuț Ioana 
Published: April 2023

Abstract
The focus of this article is the manner in which Thomas Ebendorfer of Hasselbach, a Viennese theologian lecturing on Book I of the Sentences in 1421, deals with the topic of virtus sermonis and the relation between theology, philosophy, and logic in his Prologue from the autograph MS Wien, Österreichische Nationalbibliothek, 4369 (ff. 7r–8v). By combining a double classification of each science (into acquisita vs. infusa) with a double perspective of their relation (temporal vs. natural), and by making a strong claim for theology’s role in advancing new logical theories, Ebendorfer’s view reflects a progressive awareness of the distinction between theology and philosophy which, in turn, entails very different applications of virtus sermonis in the two sciences. An edition of the Prologue is provided in the Appendix.
The Annus magnus in Albert the Great’s Parisian Theological Works
Authors: Palazzo Alessandro 
Published: April 2023

Abstract
According to the doctrine of the Great Year, after a long period of time the same astral configurations reappear and the planets return to their original positions. The end of a world cycle is marked by a natural cataclysm, after which the world is restored to its original state and history repeats itself. This article deals with Albert the Great’s views on the Great Year, focussing on two of his early theological works (the De iv coaequaevis and the Sentences commentary). The evidence here provided offers a comprehensive overview of the variety of contexts and themes which Albert considers to be related to the Great Year. He is fully aware of the many doctrinal implications of the concept of the Great Year. His analysis is deeply embedded in the astronomical discussions on the phenomenon of the precession of the equinoxes. A predominantly scientific approach is evident in the care with which he distinguishes the different types of Great Year. The major contribution of these works to the debate lies in the analysis of the impact of the Great Year on Christian eschatology and, more generally, in the investigation of the relationship between astrology and physics, on the one hand, and eschatology, on the other.
In Judgment of Unit 731: A Comparative Study of Medical War Crimes Trials after World War ii
Authors: Cranmer Valerie J. 
Published: April 2023

Abstract
The prosecution of the crimes of the Imperial Japanese Army’s Unit 731 are often compared to the prosecution of the crimes of the Nazi doctors. These comparisons emphasize immunity for the Japanese, whereas the Nazis were prosecuted for their actions. However, this comparison is an inaccurate one. While both trials look similar on the surface, their composition, scope, and framework were different. Conscious of the fact they were establishing international criminal precedent, the United States’ case against the Nazi doctors relied on military chain of command to prove strong legal responsibility for human experimentation crimes. In contrast, the United States avoided prosecuting Unit 731 because they could not replicate the same clear legal framework used to successfully prosecute the Nazis. The Soviet Union recognized the strategic implications of the United States’ decision not to try Unit 731 and saw an opportunity to strike a moral blow, not only by convicting Japanese military members at the Khabarovsk Trial, but also by immediately publishing the court’s proceedings internationally. Rather than focusing on the morality of who was punished by whom, understanding the military structures as identified through these different court proceedings could enable prevention of crimes against humanity.
Foreign Minister Tōgō’s Bitter Struggle and the Acceptance of the Potsdam Declaration
Authors: Kazuhiko Tōgō , Walsh Brian P. 
Published: April 2023

Abstract
Japan’s decision to accept the terms of the Potsdam Declaration was one of the most pivotal events in the country’s modern history. Most students of the decision-making process agree that Foreign Minister Tōgō Shigenori was the principal motive force supporting acceptance of the Allies’ demands throughout the debate over the action. Some recent historiography in Japan has questioned Tōgō’s approach, focusing particularly on his decision to seek the mediation of the Soviet Union and on the question of why he did not bring hostilities to an end sooner. Historical materials that were previously unavailable to scholars shed some light on these questions. In combination with Tōgō’s daily planner (in the author’s possession), his memoirs, and the author’s own recollection of anecdotes his parents told to him, these materials make possible a detailed examination of Tōgō’s thoughts and actions in the days leading to the acceptance of the Potsdam Declaration. This shows that Tōgō, facing stubborn resistance from the military and from public opinion, nevertheless persevered in his quest to bring the war to an end. He also maintained the trust and respect of not only Emperor Hirohito, but also of Army Minister Anami Korechika, his principal antagonist in the debate.
‘And the Nothing That Is’
Authors: Putt B. Keith 
Published: April 2023

Abstract
Richard Kearney has always insisted that his anatheistic approach to a phenomenology of the sacred stipulates a close connection with aesthetics. He supports this contention throughout his work by constantly referencing important artists, poets, novelists, and film makers. Indeed, this connection between aesthetics and his philosophy of religion has even motivated an anthology of articles entitled The Art of Anatheism. Consequently, in this essay I wish to expand that connection by examining the relationship between Kearney’s anatheism and the ‘supreme fiction’ of the American poet Wallace Stevens. To accomplish this expansion, I inspect several topics shared by the two authors, including God, faith, imagination, and ‘negative certainty’. This last topic forms something of the central focus of the essay, since I argue that the affirmative humility of faith professed by both never avoids the ‘void’ inherent in human existence that disallows every claim to the ‘innocence of an absolute’.