bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicochemic characteristics and antibacterial activity of solid soap with additional of collagen from tuna skin (Thunnus sp.)
Authors: Wenno M R , Kaya A O W , Wattimena M L , Wanci N , Patty S P A 
Published: July 2023

Abstract
Collagen is a long-chain protein compound composed of the amino acids alanine, arginine, lysine, glycine, proline, and hiroxyproline and from fishery waste, like a fish skin. This Research aims to determine the physical and chemical characteristics as well as the antibacterial activity of solid soap with the addition of tuna skin collagen and uses an experimental method (experimental) with several treatments of adding collagen. The results showed that the physical and chemical characteristics of solid soap were stability foam stability from 16.55 mm to 84.61 mm, water content ranging from 21.66 - 27.79%, pH 10.69 - 11.78, and free alkaline 1.22 - 1.92, Antibacterial activity against Staphylococcus aureus, was found in sample A2 with a diamater inhibitory zone is of 20.5 mm (very strong).
Effect of marine debris on the catching ability of bottom gill net
Authors: Matrutty Delly D P , Siahainenia Stanny R , Waileruny Welem , Noija Donald 
Published: July 2023

Abstract
Changes in internal and external factors during operation of bottom gill net will affect to catch ability of bottom gill net. The presence of marine debris in the ocean is predicted to influence the internal factors of gill nets which leads to reduction of catch ability. This study aimed to identify the factors that lead to decreasing of catch ability of bottom gill nets and to calculate the reduction of catch ability due to changes in hanging ratio caused by marine debris. Fishing activity using bottom gill net for 10 replications was conducted to identify the factors that affect the bottom gill net’s catch ability, while the reduced catch ability is calculated through the percentage of net area covered by garbage, changes in the hanging ratio and tension of the net body due to the entangled and twisted garbage in the net. The results showed that there were three factors that led to a reduction in the catch ability of bottom gill nets due to marine debris, namely: garbage stuck to the body of the net, trash entangled in net webs and trash wrapped around the body of the net. The closure of the mesh, changes in openings of mesh and net tension result in a decrease in the catch ability of bottom gill nets by 20-50%.
Diversity of gastropods as bioindicator of the coastal waters of Inner Ambon Bay
Authors: Supusepa J , Hulopi M , Sahetapy J M F 
Published: July 2023

Abstract
The beach in Inner Ambon Bay is used by coastal communities to carry out various activities including household waste disposal, fishing activities and tourism. These activities cause the entry of waste into water bodies resulting in a decrease of water quality. This will lead to pollution on the coast if left unchecked. One of the resources living on the coast is gastropods which are generally able to describe waters conditions, so their presence can be used as an indicator for determining water quality. This study aims to determine the diversity of gastropods and the conditions of Halong coastal waters. This research was conducted in 2022 on the coast of Halong waters. Gastropods were collected using the belt transect method with distance between transects is 50 m. Gastropods collected were identified morphologically using standard literature book. Analysis was conducted to determine species density and ecological index of gastropods. The condition of the coastal waters of Halong was determined using STORET method and ABC curve method. The results showed that gastropods in the coastal waters of Halong consist of 3 orders, 13 families, 16 genera and 28 species with the highest density belongs to Cortica herbs. Diversity and evenness of gastropod in the area can be categorized as moderate with low dominance. Analysis of physical, chemical and biological parameter indicate that coastal waters of Halong was moderately polluted.
Measurement-based ZIP load modelling using opposition based differential evolution optimization
Authors: Kumar Abhinav , Mallik Sanjeev Kumar 
Published: July 2023

Abstract
With the large integration of distributed generations, power grids are on the verge of instability if the generation and load side is not synchronized properly. To predict the load, a proper load model should be developed for the purpose of power system monitoring. The ZIP load model is considered in this work due to its simplicity. The parameter of the ZIP load corresponding to constant power, constant impedance, and constant current load must be estimated accurately for predicting the load behavior. In this paper, the measurements are being compared with the estimated value for estimating the load parameters using a suitable parameter tuning method. For ZIP load modeling Measurement-based parameter estimation is applied. In this paper, measurements are simulated by statistically infusing the Gaussian noise into the true value (obtained from the load flow study). The parameter-tuning algorithm iteratively feeds the error discovered from the comparison to determine the optimal solution. In this paper, Opposition-based differential evolution optimization (ODEO) is being proposed as a parameter tuning method for estimating the load parameters from the measurements collected at a given load bus. Measurement of the ZIP load is collected at bus 30 of the NE 39 Bus system after applying step disturbance of voltage at generator 4. The proposed ODEO method is validated and compared with the other tuning methods, like Particle Swarm optimization (PSO) and Grey Wolf optimization (GWO). The proposed ODEO method has a better performance as compared to PSO and GWO.
Efficacy of Allisartan Isoproxil in the Treatment of Mild-to-Moderate Essential Hypertension
Authors: Wang Hongyi , Xi Yang , Chen Yuanyuan , Wang Luyan , Yang Fan , Lu Xining , Sun Ningling 
Published: July 2023

Abstract

BACKGROUND
Allisartan isoproxil is a selective nonpeptide angiotensin II (AT1) receptor blocker developed by China, this study aimed to assess its clinical efficacy for essential hypertension (EH).

METHODS
Patients with mild-to-moderate EH, selected at 44 sites in China from September 9, 2016, to December 7, 2018, were administered 240 mg allisartan isoproxil daily for 4 weeks. Patients with controlled blood pressure (BP) continued monotherapy for 8 weeks, others were randomly assigned (1:1) to A + D group (allisartan isoproxil 240 mg + indapamide 1.5 mg) or A + C group (allisartan isoproxil + amlodipine besylate 5 mg) for 8 weeks. BP were measured at week 4, 8 and 12.

RESULTS
2,126 patients were included in the analysis. After 12 weeks of treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) decreased by 19.24 ± 12.02 and 10.63 ± 8.89 mm Hg, respectively, and the overall BP control rate was 78.56%. The sitting blood pressures (SBP/DBP) decreased by 19.12 ± 11.71/10.84 ± 8.73 mm Hg in patients with 12 weeks allisartan isoproxil monotherapy (both P &lt; 0.0001). The BP reductions and control rates were comparable between A + D and A + C groups. 48 patients with monotherapy-controlled BP underwent ambulatory BP monitoring, with a mean decrease in ambulatory BP of 10.04 ± 10.87/5.50 ± 8.07 mm Hg after 12 weeks of treatment, and consistent reductions between day and night. SBP and DBP had trough-to-peak ratios of 64.64% and 62.63% and smoothness indices of 3.82 and 2.92, respectively.

CONCLUSIONS
An allisartan isoproxil-based antihypertensive regimen can effectively control BP in patients with mild-to-moderate EH.

PROJECT REGISTRATION NO
CTR20160138 (Registration and Information Disclosure Platform for China Drug Clinical Studies, http://www.chinadrugtrials.org.cn/index.html).
Enhancing biomedical search interfaces with images
Authors: Trelles Trabucco Juan , Arighi Cecilia , Shatkay Hagit , Marai G Elisabeta 
Published: July 2023

Abstract

Motivation
Figures in biomedical papers communicate essential information with the potential to identify relevant documents in biomedical and clinical settings. However, academic search interfaces mainly search over text fields.

Results
We describe a search system for biomedical documents that leverages image modalities and an existing index server. We integrate a problem-specific taxonomy of image modalities and image-based data into a custom search system. Our solution features a front-end interface to enhance classical document search results with image-related data, including page thumbnails, figures, captions and image-modality information. We demonstrate the system on a subset of the CORD-19 document collection. A quantitative evaluation demonstrates higher precision and recall for biomedical document retrieval. A qualitative evaluation with domain experts further highlights our solution’s benefits to biomedical search.

Availability and implementation
A demonstration is available at https://runachay.evl.uic.edu/scholar. Our code and image models can be accessed via github.com/uic-evl/bio-search. The dataset is continuously expanded.
The Boundedness of Stable Solutions to Semilinear Elliptic Equations With Linear Lower Bound on Nonlinearities
Authors: Peng Fa 
Published: July 2023

Abstract
Let $2\le n\le 9$. Suppose that $f:{{\mathbb {R}}}\to {{\mathbb {R}}}$ is locally Lipschitz function satisfying $f(t)\ge A\min \{0,t\}-K$ for all $t\in {{\mathbb {R}}}$ with some constant $A\ge 0$ and $K\ge 0$. We establish an a priori interior Hölder regularity of $C^{2}$-stable solutions to the semilinear elliptic equation $-\Delta u=f(u)$. If, in addition, $f$ is nondecreasing and convex, we obtain the interior Hölder regularity of $W^{1,2}$-stable solutions. Note that the dimension $n\le 9$ is optimal.
Serologic Testing for Rocky Mountain Spotted Fever in a Low-Incidence Region
Authors: Wang Joye , Handel Andrew S 
Published: July 2023

Abstract

Background
Tick-borne diseases have grown in incidence over recent decades. As a result, diagnostic testing has become more common, often performed as broad antibody-based panels for multiple tick-transmitted pathogens. Rocky Mountain spotted fever (RMSF) is rare in our region yet may cause severe morbidity, leading to diagnostic screening in low-risk patients. We sought to describe trends in RMSF diagnostic testing, rate of IgG seropositivity, and clinical features of those tested.

Methods
We performed a retrospective chart review of patients ≤21 years old undergoing testing for RMSF and/or with an ICD-9/10 code for RMSF. Patients were categorized by infection likelihood based on clinical and laboratory criteria adapted from Centers for Disease Control and Prevention’s (CDC) case definition of spotted fever rickettsioses. Clinical data were collected and analyzed with descriptive statistics.

Results
One hundred and seventy patients were included. 5.8% met CDC criteria for rickettsial infection, 6.5% had an elevated IgG titer but lacked suggestive symptoms, and 87.6% had a negative IgG titer. Many patients tested were unlikely to have RMSF, including 50% lacking fever, 20% lacking any RMSF “classic triad” symptoms, 13% without acute illness, and 22% tested during months with low tick activity. Convalescent serology was performed in 7.6% of patients and none underwent Rickettsia rickettsii polymerase chain reaction (PCR) testing.

Conclusions
Diagnostic testing was frequently performed in patients unlikely to have RMSF. We identified many opportunities for improving test utilization. Reserving testing for those with higher pretest probability, performing convalescent serology, and utilizing PCR may improve the accuracy of RMSF diagnosis and reduce clinical challenges stemming from inappropriate testing.
Estimating the Size of Clustered Hidden Populations
Authors: Gamble Laura J , Johnston Lisa G , Pham Phuong N , Vinck Patrick , McLaughlin Katherine R 
Published: July 2023

AbstractSuccessive sampling population size estimation (SS-PSE) is a method used by government agencies, aid organizations, and researchers around the world to estimate the size of hidden populations using data from respondent-driven sampling surveys. SS-PSE addresses a specific need in estimation, since many countries rely on having accurate size estimates to plan and allocate finite resources to address the needs of hidden populations. However, SS-PSE relies on several assumptions, one of which requires the underlying social network of the hidden population to be fully connected. We propose two modifications to SS-PSE for estimating the size of hidden populations whose underlying social network is composed of disjoint clusters. The first method is a theoretically straightforward extension of SS-PSE, but it relies on prior information that may be difficult to obtain in practice. The second method extends the Bayesian SS-PSE model by introducing a new set of parameters that allow for clustered estimation without requiring the additional prior information. After providing theoretical justification for both novel methods, we then assess their performance using simulations and apply the Clustered SS-PSE method to a population of internally displaced persons in Bamako, Mali.
Cut-off values of haemoglobin and clinical outcomes in incident peritoneal dialysis: the PDTAP study
Authors: Xu Xiao , Yang Zhikai , Li Shaomei , Pei Huayi , Zhao Jinghong , Zhang Ying , Xiong Zibo , Liao Yumei , Li Ying , Lin Qiongzhen , Hu Wenbo , Li Yulin , Zheng Zhaoxia , Duan Liping , Fu Gang , Guo Shanshan , Zhang Beiru , Yu Rui , Sun Fuyun , Ma Xiaoying , Hao Li , Liu Guiling , Zhao Zhanzheng , Xiao Jing , Shen Yulan , Zhang Yong , Du Xuanyi , Ji Tianrong , Wang Caili , Deng Lirong , Yue Yingli , Chen Shanshan , Ma Zhigang , Li Yingping , Zuo Li , Zhao Huiping , Zhang Xianchao , Wang Xuejian , Liu Yirong , Gao Xinying , Chen Xiaoli , Li Hongyi , Du Shutong , Zhao Cui , Xu Zhonggao , Zhang Li , Chen Hongyu , Li Li , Wang Lihua , Yan Yan , Ma Yingchun , Wei Yuanyuan , Zhou Jingwei , Li Yan , Zheng Yingdong , Wang Jinwei , Zhao Ming-hui , Dong Jie ,   the PDTAP working group
Published: July 2023

ABSTRACT

Background
To explore the cut-off values of haemoglobin (Hb) on adverse clinical outcomes in incident peritoneal dialysis (PD) patients based on a national-level database.

Methods
The observational cohort study was from the Peritoneal Dialysis Telemedicine-assisted Platform (PDTAP) dataset. The primary outcomes were all-cause mortality, major adverse cardiovascular events (MACE) and modified MACE (MACE+). The secondary outcomes were the occurrences of hospitalization, first-episode peritonitis and permanent transfer to haemodialysis (HD).

Results
A total of 2591 PD patients were enrolled between June 2016 and April 2019 and followed up until December 2020. Baseline and time-averaged Hb &lt;100 g/l were associated with all-cause mortality, MACE, MACE+ and hospitalizations. After multivariable adjustments, only time-averaged Hb &lt;100 g/l significantly predicted a higher risk for all-cause mortality {hazard ratio [HR] 1.83 [95% confidence interval (CI) 1.19–281], P = .006}, MACE [HR 1.99 (95% CI 1.16–3.40), P = .012] and MACE+ [HR 1.77 (95% CI 1.15–2.73), P = .010] in the total cohort. No associations between Hb and hospitalizations, transfer to HD and first-episode peritonitis were observed. Among patients with Hb ≥100 g/l at baseline, younger age, female, use of iron supplementation, lower values of serum albumin and renal Kt/V independently predicted the incidence of Hb &lt;100 g/l during the follow-up.

Conclusion
This study provided real-world evidence on the cut-off value of Hb for predicting poorer outcomes through a nation-level prospective PD cohort.
Complete Genome Sequence of Bacillus velezensis LQ-3, a Biocontrol Agent Against Rhizoctonia cerealis, Isolated from Wheat Soil
Authors: Li Rong , Yang Panlei , Liu Jiehui , Zhang Hongjuan , Zhao Fang , Wang Yanbin , Liang Yan , Hong He , Wang Chunjing , Xie Xiansheng , Zeng Qingchao 
Published: July 2023

Bacillus velezensis LQ-3 was previously isolated from wheat soil and has been found to exhibit strong biocontrol activity against Rhizoctonia cerealis. To better understand its biocontrol mechanism, we utilized both Illumina and Nanopore sequencing technologies to sequence the whole genome of LQ-3. Our analysis revealed that the assembled genome of strain LQ-3 was 3,929,792 bp in length and contained one chromosome with a G+C content of 46.50%. We also identified 3,747 coding sequence genes, 86 tRNA genes, 27 rRNA genes, and one tmRNA gene. The LQ-3 genome contained 12 biosynthetic gene clusters responsible for secondary metabolite production. This genome sequence analysis is crucial for understanding the biocontrol mechanism of B. velezensis LQ-3 and serves as a foundation for the development and industrialization of biocontrol agents. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Long-term Childhood Outcomes for Babies Born at Term Who Were Exposed to Antenatal Corticosteroids
Authors: Osteen Samantha J. , Yang Ziyi , McKinzie Alexandra H. , Teal Evgenia , Tepper Robert S. , Rhoads Eli , Quinney Sara K. , Haneline Laura S. , Haas David M. 
Published: July 2023

(Abstracted from Am J Obstet Gynecol 2023;228(1):80.e1–80.e6)
The use of antenatal corticosteroids (ACSs) is standard practice for women who are at risk of preterm birth to accelerate the development of vital organs, in particular the fetal lungs. Previous research has shown the efficacy of this treatment and its benefits in infants who are born preterm, but there is little research on the effects of ACS on infants who are subsequently born at term.
Rate of Manifesting Carriers and Other Unexpected Findings on Carrier Screening
Authors: Clevenger Sydney K. , Brandt Justin S. , Khan Shama P. , Shingala Pranali , Carrick Jillian , Aluwalia Ruchi , Heiman Gary A. , Ashkinadze Elena 
Published: July 2023

(Abstracted from Prenat Diagn 2023;43:117–125)
Obstetric care includes many types of assessment of both mother and baby, including screening for genetic conditions. This can be done through genetic tests referred to as carrier screening, which detect carriers at risk to have children with autosomal recessive and X-linked recessive conditions.
Noninvasive Prenatal Screening for Cystic Fibrosis Using Circulating Trophoblasts: Detection of the 50 Most Common Disease-Causing Variants
Authors: Jeppesen Line Dahl , Lildballe Dorte Launholt , Hatt Lotte , Hedegaard Jakob , Singh Ripudaman , Toft Christian Liebst Frisk , Schelde Palle , Pedersen Anders Sune , Knudsen Michael , Vogel Ida 
Published: July 2023

(Abstracted from Prenat Diagn 2023;43:3–13)
Autosomal recessive disorders can have a significant impact on quality of life for parents and individuals. One of the most common but also potentially severe of these disorders is cystic fibrosis (CF), a disorder that causes pulmonary and pancreatic dysfunction.
The use of environmental exposure chambers in studies related to ocular surface effects
Authors: Gherasim Alina , Bielory Leonard 
Published: July 2023

Purpose of review
The potential of allergen challenges using environmental exposure facilities in allergic conjunctivitis drug development and more recently its implication on the diagnosis of the united airways concept have been emphasized in the recent literature. This study aims to present an overview of new and important data in this field.

Recent findings
Standardized methodologies for ocular surface assessment during allergen challenges were described. The Total Ocular Symptom Score (TOSS) is the main validated questionnaire used for the assessment of ocular surface during allergen challenges. It combines patient and investigator assessments for more accurate conjunctival response and was extensively used in clinical research and daily practice. Environmental Exposure Chambers (EECs) studies aim to conduct tight-controlled challenges to a stable and well defined allergen airborne concentration, closer to natural exposure to evaluate the efficacy of nonpharmaceutical and antiallergic treatments. Recent studies showed a good correlation between ocular symptoms elicited by EEC and those assessed during natural exposure. These validated methods allow to investigate the efficacy of novel pharmacotherapies for allergic conjunctivitis and allergen immunotherapy (AIT) in a real-world model of allergen exposure.

Summary
This study aims to summarize novel data regarding the impact of EECs in studying pathophysiology and drug efficacy in the context of existing clinical protocols related to ocular surface effects. In this regard, studies comparing conjunctival response during natural and EEC exposures in patients with pollen-induced conjunctivitis aimed to demonstrate better outcomes in tight-controlled exposures mimicking natural exposure. Because allergen challenges are widely implemented in allergy treatment, this article will focus on the most important outcomes and the evolution of treatments for allergic conjunctivitis.
Assessing Geographic Variation in Rates of Cervical Cancer and Recurrent or Metastatic Cervical Cancer Among Medicaid Enrollees
Authors: Leath Charles A. , Nysenbaum Jessica , Ting Jie , Zhang Yitong J. , Fiori Anthony , Pauly Nathan 
Published: July 2023

Objective:
The objective of this study was to evaluate trends in prevalence of cervical cancer (CC) and rates of recurrent or metastatic cervical cancer (r/mCC) treatment initiation at the state and metropolitan statistical area (MSA) levels among Medicaid enrolled females from 2016 to 2019.

Methods:
Retrospective analyses of nationwide Medicaid claims data were used to identify adult CC and r/mCC patients from 2016 to 2019. CC prevalence was estimated as the proportion of females diagnosed with CC out of all adult female Medicaid beneficiaries, and r/mCC by the proportion of CC patients who initiated a systemic treatment not associated with surgery or radiation to the number of enrollees with CC diagnosis in each state or MSA. Overall and annual rates were calculated for each state and MSA from 2016 to 2019.

Results:
The analytic cohort included 70,865 adult female Medicaid beneficiaries with CC from 2016 to 2019, among whom 3375 were identified as r/mCC patients. Nationwide annual prevalence of CC remained relatively stable from 2016 to 2019, while r/mCC decreased slightly over the study period. Several MSAs experienced increasing rates of r/mCC from 2016 to 2019, including Mayaguez, PR, Aguadeilla-Isabela, PR, and Green Bay, WI.

Conclusions:
Claims data demonstrate areas in the United States with disproportionately high or increasing CC or r/mCC burden, indicating a potential gap in preventative care for females and an unmet need for education and health care resource allocation. Future research should evaluate associations between community-level factors and r/mCC burden.