bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infantile epileptic spasms syndrome: an etiologic study of 361 patients with infantile epileptic spasms syndrome
Authors: Zhu Linghui , Xia Yuan , Ding Hao , Zhang Tong , Li Jun , Li Baomin 
Published: January 2025

IntroductionInfantile Epileptic Spasms Syndrome (IESS) typically has a profound impact on the neurodevelopment of patients. The study on IESS indicates possible geographical variation in etiology and a lack of data from China. Our study intends to summarize the etiology of IESS and analyze its characteristics.MethodsA retrospective analysis was performed to gather clinical data from patients diagnosed with IESS at the Department of Neurology of Qilu Hospital of Shandong University and the Children's Hospital Affiliated to Shandong University between June 2017 to May 2024.ResultsA total of 361 patients with IESS were included, comprising 115 structural cases (31.9%), 37 genetic cases (10.2%), 32 genetic-structural cases (8.9%), 9 metabolic cases (2.5%), 3 infectious cases (0.8%), and 165 cases with unknown etiology (45.7%). No immunological cause was determined. The primary cause of the condition was linked to hypoxic-ischemic encephalopathy (HIE), with structural brain abnormalities following closely. The predominant pathogenic genes identified were TSC2, NF1, SCN8A, and KCNQ2. Male gender, preterm infants, low birth weight infants, and developmental regression in patients were associated with a higher likelihood of structural etiology. Patients exhibiting developmental regression before the commencement demonstrated inferior outcomes. Patients administered adrenocorticotropic hormone (ACTH) exhibited a higher likelihood of attaining seizure control, and those who responded favorably to the medication saw improved results.ConclusionThe predominant etiology of IESS is structural, succeeded by genetic factors, with significant pathogenic genes comprising TSC2, NF1, SCN8A, and KCNQ2. The genetic classifications exhibit geographic variability. Genetic and structural etiologies are frequently linked to an unfavorable prognosis. Genetic testing can help clarify the etiology of IESS when metabolic screening and brain MRI results are negative. The advancement of genetic testing is crucial for future targeted and individualized diagnosis and therapy.
Association of early aspirin use with 90-day mortality in patients with sepsis: an PSM analysis of the MIMIC-IV database
Authors: Huang Chunsheng , Tong Qiaoling , Zhang Wenyuan , Pan Zhihao 
Published: January 2025

ObjectiveIn addition to its antiplatelet and anti-inflammatory properties, aspirin inhibits bacterial proliferation directly. The potential benefits of aspirin may enhance the prognosis for sepsis patients. However, little is known about the effects of early aspirin administration. This study aimed to examine the correlation between the administration of aspirin at an early stage and the 90-day mortality rate among sepsis patients.MethodsIn order to distinguish between septic patients who received early aspirin treatment and those who did not, queries were conducted on the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The principal metric utilized was 90-day mortality. We determined the association between early aspirin use and 90-day mortality using multivariate Cox regression, and propensity score matching (PSM) was utilized to validate our findings. The analyses of the subgroups have been completed.ResultsOur analysis comprised 28,425 septic patients, of whom 7,568 (26.6%) received aspirin within 24 h of intensive care unit (ICU) admission. The aspirin users group had a lower 90-day mortality than the aspirin nonusers group [1,624 (21.8%) vs. 2,035 (27.3%), P &lt; 0.001]. The logistic regression showed that early aspirin use was associated with a lower 90-day mortality (OR, 0.74, 95% CI, 0.69–0.80, P &lt; 0.001). K-M curve analysis showed that the 90-day mortality of the aspirin users group was significantly lower than that of the aspirin nonusers group (P &lt; 0.001). Subgroup analysis revealed comparable relationships between early aspirin use and 90-day mortality among individuals.ConclusionIn conclusion, early aspirin use was associated with decreased in-hospital and 90-day mortality in septic patients, emphasizing the significance of early aspirin use administration in the ICU.
Integrating traditional machine learning with qPCR validation to identify solid drug targets in pancreatic cancer: a 5-gene signature study
Authors: Wang Xiaoyan , Yu Pengcheng , Jia Wei , Wan Bingbing , Ling Zhougui , Tang Yangyang 
Published: January 2025

BackgroundPancreatic cancer remains one of the deadliest malignancies, largely due to its late diagnosis and lack of effective therapeutic targets.Materials and methodsUsing traditional machine learning methods, including random-effects meta-analysis and forward-search optimization, we developed a robust signature validated across 14 publicly available datasets, achieving a summary AUC of 0.99 in training datasets and 0.89 in external validation datasets. To further validate its clinical relevance, we analyzed 55 peripheral blood samples from pancreatic cancer patients and healthy controls using qPCR.ResultsThis study identifies and validates a novel five-gene transcriptomic signature (LAMC2, TSPAN1, MYO1E, MYOF, and SULF1) as both diagnostic biomarkers and potential drug targets for pancreatic cancer. The differential expression of these genes was confirmed, demonstrating their utility in distinguishing cancer from normal conditions with an AUC of 0.83. These findings establish the five-gene signature as a promising tool for both early, non-invasive diagnostics and the identification of actionable drug targets.ConclusionA five-gene signature is established robustly and has utility in diagnostics and therapeutic targeting. These findings lay a foundation for developing diagnostic tests and targeted therapies, potentially offering a pathway toward improved outcomes in pancreatic cancer management.
Effect of operational parameters on droplet deposition characteristics using an unmanned aerial vehicle for banana canopy
Authors: Yu Jiaxiang , Xu Xing , Duan Jieli , Jiang Yinlong , Yuan Haotian , Liang Huazimo , Jing Shuaijie , Yang Zhou 
Published: January 2025

In recent years, as an important part of precision agricultural aviation, the plant protection unmanned aerial vehicle (UAV) has been widely studied and applied worldwide, especially in East Asia. Banana, as a typical large broad-leaved crop, has high requirements for pests and diseases control. The mechanization degree of plant protection management in banana orchard is low. Therefore, our study focuses on the effects of different flight heights (3-5 m) and droplet sizes (50-150 μm) of plant protection UAV on the droplet deposition distribution characteristics of banana canopy. And the droplet deposition distribution in banana canopy and spraying drift of plant protection UAV and ground air-assisted sprayer were compared. The results showed that droplet size was the main factor affecting droplet deposition density, coverage, uniformity and penetration on both sides of banana canopy leaves. The droplet deposition density and coverage on the adaxial side of leaves were mostly significantly larger than that on the abaxial side. The flight height of 4 m and the droplet size of 100 μm could make the adaxial side of banana canopy leaves have higher droplet deposition density (63.77 droplets per square cm) and coverage (12.75%), and can make the droplets effectively deposit on the abaxial side of banana canopy leaves, with droplet deposition density of 17.46 droplets per square cm and coverage of 1.24%. Choosing an appropriate flight height and a droplet size could improve the droplet deposition uniformity on both sides of banana canopy leaves, but the improvement was not significant. Moreover, at a same operational parameter combination, it was difficult to achieve the best droplet deposition density, coverage, uniformity and penetration at the same time. In addition, appropriately increasing the flight height and droplet size could help to improve the droplet deposition penetration on the adaxial side of banana canopy leaves, but there were few significant improvements. Compared with the plant protection UAV, the ground air-assisted sprayer had higher droplet deposition density and coverage on the abaxial side of banana canopy leaves, but had smaller droplet deposition coverage on the adaxial side. The droplet deposition density and coverage on the abaxial side of banana canopy leaves were obviously larger than the adaxial side during the spraying of ground air-assisted sprayer. The droplet drift distance of the ground air-assisted sprayer was farther than the plant protection UAV. The test results of this study can provide practical and data support for the UAV aerial application in banana orchard, and provide a valuable reference for the implementation of air-ground cooperation spraying strategy in banana orchard, which is of great significance to promote sustainable and intelligent phytoprotection of banana orchard.
Effects of the narrative elaboration technique and open-ended rapport on accuracy of children’s recall according to age
Authors: Lee Seungjin , Shin Minkyeong 
Published: January 2025

IntroductionThis study explored the impacts of the narrative elaboration technique (NET) and open-ended rapport building on younger (n = 30, ages 5–6) and older (n = 30, ages 7–8) children’s free recall and suggestibility.MethodsChildren were randomly assigned to either a NET condition or an open-ended rapport condition after engaging in a photo-taking play session with an experimenter. Then, a novel interviewer asked them about the play session. The effects of the experimental conditions on children’s free recall and suggestibility were examined according to children’s age groups.ResultsResults revealed that open-ended rapport played a more significant positive role in young children’s free recall and suggestibility when compared to NET. No significant differences were observed in the effects of NET and open-ended rapport on older children’s memory performance.DiscussionPractical guidance is provided in terms of prioritizing open-ended rapport over NET to maximize young children’s spontaneous and accurate recall.
Cross-cultural validation and reference norms for the DCDDaily-Q questionnaire Chinese version (DCDDaily-Q-CN): evaluating children’s motor performance in activities of daily living
Authors: Huang Meihuan , Zhan Yujun , Zhou Haishan , Song Ping , Fan Yanping , Lu Yang , Chen Yijing , Lv Zhen , Liu Qing , Yun Guojun , Cao Jianguo 
Published: January 2025

BackgroundThe DCDDaily-questionnaire (DCDDaliy-Q) evaluates children’s performance and participation in motor-based activities of daily living (ADLs), meeting diagnostic criterion B for developmental coordination disorder (DCD). Currently, there are no Chinese translations or growth references available. Thus, this study aimed to culturally adapt, validate, and establish reference norms for the DCDDaily-Q in Chinese children.MethodsThe original scale was translated and culturally adapted into Chinese (DCDDaily-Q-CN) following international guidelines. Normative data of typically developing children (n = 1936, aged 5–10) were gathered from 14 randomly chosen mainstream schools in a large migrant city. Thirty children (aged 5–10 years) diagnosed with DCD were recruited through clinical referrals, and a matched control group (n = 30) was randomly selected from the reference group. Reference norms with growth curves and psychometric properties were analyzed.ResultsSex-specific growth curves with percentiles and cut-off values of the DCDDaily-Q-CN in children aged 5–10 years were established. The instrument demonstrated excellent internal consistency across the total and the three subscales (Cronbach’s alpha = 0.83–0.91). The confirmatory factor analysis showed a good fit for the original three-factor model (CFI = 0.936, RMSEA = 0.049). Moderate to strong correlations were found between the DCDDaily-Q-CN performance total score and the DCDQ-R (rs = −0.54) and MABC-2 total scores (rs = −0.68). The total performance score effectively differentiated between children with DCD and controls (U = 9.0, p &lt; 0.001), with a cutoff score of 45, demonstrating a sensitivity of 93% (95%CI: 77–99%) and specificity of 90% (95%CI: 74–98%).ConclusionThe findings support that the DCDDaily-Q-CN is a reliable and valid measure to assess participation and performance in motor-based ADLs and fulfill criterion B of the diagnostic criteria for DCD.
Dynamic-budget superpixel active learning for semantic segmentation
Authors: Wang Yuemin , Stavness Ian 
Published: January 2025

IntroductionActive learning can significantly decrease the labeling cost of deep learning workflows by prioritizing the limited labeling budget to high-impact data points that have the highest positive impact on model accuracy. Active learning is especially useful for semantic segmentation tasks where we can selectively label only a few high-impact regions within these high-impact images. Most established regional active learning algorithms deploy a static-budget querying strategy where a fixed percentage of regions are queried in each image. A static budget could result in over- or under-labeling images as the number of high-impact regions in each image can vary.MethodsIn this paper, we present a novel dynamic-budget superpixel querying strategy that can query the optimal numbers of high-uncertainty superpixels in an image to improve the querying efficiency of regional active learning algorithms designed for semantic segmentation.ResultsFor two distinct datasets, we show that by allowing a dynamic budget for each image, the active learning algorithm is more effective compared to static-budget querying at the same low total labeling budget. We investigate both low- and high-budget scenarios and the impact of superpixel size on our dynamic active learning scheme. In a low-budget scenario, our dynamic-budget querying outperforms static-budget querying by 5.6% mIoU on a specialized agriculture field image dataset and 2.4% mIoU on Cityscapes.DiscussionThe presented dynamic-budget querying strategy is simple, effective, and can be easily adapted to other regional active learning algorithms to further improve the data efficiency of semantic segmentation tasks.
Programas de entrenamiento cognitivo para la mejora de actividades de la vida diaria del adulto mayor
Authors: Intriago Ceme Geness Valeria , Rodas José Antonio 
Published: January 2025

En la población de adultos mayores, se ha constatado una vinculación significativa entre el deterioro cognitivo y la disminución de su funcionalidad. Un método para mejorar o prevenir deterioros cognitivos que ha generado mucha atención en los últimos años son los entrenamientos cognitivos computarizados. Este es un tipo de entrenamiento o rehabilitación cognitiva que se presenta a través de computadoras y usualmente involucra actividades dirigidas a diversos procesos mentales, como la atención y la memoria. Es notable en la literatura el creciente interés en intervenciones con ordenadores y el uso de nuevas tecnologías para estudiar su impacto en la cognición. Sin embargo, hay pocos estudios sobre las ganancias secundarias. El propósito de esta investigación es identificar los beneficios de los entrenamientos cognitivos en las actividades de la vida diaria del adulto mayor. A través de una revisión literaria no sistemática, se describen los antecedentes del tema y los avances más recientes en el área. Pudimos encontrar que la mayoría de los programas suelen estar dirigidos a procesos cognitivos complejos específicos como la memoria de trabajo, pero también suelen incorporar elementos comportamentales complejos como actividad física. Se concluye que los programas de entrenamiento cognitivo pueden mejorar el funcionamiento cognitivo global y áreas específicas como la memoria, aunque la transferencia a largo plazo de estos beneficios a las actividades diarias aún no se comprende completamente y represente un área de investigación necesaria.
What’s been tried: a curated catalogue of efforts to improve access to general practice
Authors: Sinnott Carol , Price Evleen , Ansari Akbar , Fisher Rebecca , Beech Jake , Alderwick Hugh , Dixon-Woods Mary 
Published: January 2025

BackgroundAlthough increasing numbers of appointments are being provided, public satisfaction with access to UK general practice is declining. Previous attempts to improve access have not been systematically collated.AimWe aimed to identify interventions to improve access to general practice in the UK, to organise these interventions into thematic categories, and to identify which aspects of access are targeted.Design & settingNarrative systematic review.MethodA three-stage search was conducted to identify interventions used to improve access to NHS general practice. Using an iterative process, we generated thematic categories to classify interventions according to how they are intended to work. We assessed which aspects of access they addressed using the seven-feature Candidacy Framework.ResultsThe search identified 449 relevant sources reporting on interventions to improve access to general practice over the period 1984-2023. We generated six overarching thematic categories into which we organised these interventions: appointment innovations; direct patient access to services; increasing the number and range of professionals available in general practice; offering contacts beyond core hours, core settings and core services; supporting patient engagement; and supporting the wider structures of general practice. We assessed which features of Candidacy were addressed, with “permeability” (the ease with which people can use) services emerging as the most frequent feature.ConclusionMultiple and diverse attempts have been made to improve access in general practice over a 40-year period. This curated, thematised catalogue offers an important resource for future efforts to improve access.
Recurrent anterior dislocation of radial head treated with ulnar distraction osteotomy and reconstruction of annular ligament using palmaris longus tendon with bioabsorbable screw anchoring: A case report
Authors: Winanto Iman Dwi , Siregar Alamsyah Faritz , Nugraha Tesar Akbar 
Published: January 2025

Introduction: Radial head dislocation in children may be either congenital, an isolated injury or more commonly part of a complex injury to the elbow. Isolated traumatic radial head dislocation in children is a rare and easily missed condition.The reported case shows various treatment and intervention with ulnar osteotomy and annular ligament reconstruction in order to reach the definitive reduction of recurrent dislocation of radial head.
Case Presentation: Male 9 years old with anterior dislocation of the radial head, came with difficulty on flexing his elbow due to bony prominence on his anterior elbow. He had recurrent radial head dislocation with redundant annular ligament. From the physical examination there was a prominent radial head on anterior region of elbow. From x-ray examination we found anterior dislocation of ulnar head without any fracture or deformity of ulna. Patient underwent ulnar distraction osteotomy to achieve radial traction and allow stable reduction of radial head. After 5 months he had reconstruction of annular ligament with palmaris longus tendon graft and anchoring with bioabsorbable screw in order to reduce and stabilize the radial head.
Conclusion: In this case we found ulnar osteotomy may gave improvement for the reduction of the radial head. But additional annular ligament reconstruction give stability of the radial head which will held in place with full range of motion of the elbow. So this combined procedures hopefully can gave best achievement and satisfactory results of the children and last a lifetime.
تحليل لغوي تداولي لخطاب جودة الحياة قائم على المدونة القرآنية العربية.
Authors: الأسمري جوهرة سعيد 
Published: January 2025

يسعى هذا البحث إلى مسعىً مزدوج الشق، وهو مسعى نظري بطبيعته، ويرتكز في الوقت نفسه على التطبيقات العملية. الهدف الأساسي منه تسليط الضوء على النسيج المعقّد الذي نسجته المفردات المعجمية، والأساليب النحوية، والتفاعل الدقيق داخل الخطابات التي تدور حول المفهوم المراوغ لـ (جودة الحياة QoL). وتعتمد منهجية البحث على المفهوم المعقد لـ (السمة) كما تظهر في القرآن الكريم. وللقيام بذلك اخترتُ أهم المصطلحات التي تحمل في طياتها معاني تمثّل الحياة، باستخدام تقنية (تقاطع النصوص)؛ حيث حلّلت مجموعة من النصوص وقارنتها ببعضها لاستخلاص الاتجاه أو السمة العامة لها؛ وذلك من خلال أدوات البحث في موقع المدونة القرآنية، مع تحليل إحصائي لتواترها في المجموعة.
تكشف نتيجة هذا البحث عن كشف مذهل من التعقيدات العميقة لاستخدام اللغة من خلال نقل مؤشرات متعددة الأوجه لجودة الحياة؛ حيث يتشابك بناء الجملة والدلالات المعجمية؛ مما يصوغ نسيجًا من الخطابات ذات المغزى. ومن الجدير بالذكر أن المصطلح الدقيق (نوعية الحياة) تظل غائبة غيابًا واضحًا عن الآيات القرآنية. فضلًا عن ذلك، فإن كلمة (الجودة) نفسها ما تزال بمنأى عن الذكر صراحة. ومع ذلك، يظهر هذا المفهوم ظهورا جليًّا. ومن المثير للاهتمام أن الفحص يسفر أيضًا عن ظهور هذا المفهوم من خلال مجموعة من أربعة مؤشرات بارزة لجودة الحياة، ولكل منها صدى ذو أهمية عميقة. وهي تشمل مجالات الإيمان والعبادة، والفكر والمعرفة، وسبل العيش، والمعاملات البشرية.
Modifikasi Sistem Pengapian Konvensional ke CDI pada Motor Dua Langkah
Authors: Sarjono  , Dody Alfianto  , Wahyu Diono  
Published: January 2025

The purpose of this research is to determine the performance, exhaust emissions and fuel consumption of 2-stroke motorcycles by comparing conventional ignition and CDI systems. To find out the performance, power and torque tests were carried out on a 2-stroke motorcycle, the results of tests that have been carried out on variations of conventional ignition and CDI ignition, it is known that the use of CDI ignition has the highest power of 11.1 HP at 6250 RPM engine speed in 1.98 seconds. The use of CDI ignition has the highest torque of 12.58 Nm at 6250 RPM in 1.98 seconds. The lowest fuel consumption at 5250 rpm is 29.2 ml/min using CDI ignition. While the highest CO exhaust emissions in this study, using CDI ignition variation at 5000 rpm with an average value of 5.00% with pertalite fuel, The highest HC exhaust gas emissions in this study with an average value of 9999 ppm.
Comparaison of incisional and endoscopic percutaneous gastropexy techniques in dogs: a preventive approach to gastric dilatation-volvulus syndrome
Authors: Hithem Bougherara , Saïd Boukhechem , Leila Dib Amira , Adel Aissi 
Published: January 2025

Prophylactic gastropexy is the most effective method to prevent gastric dilatation and volvulus syndrome in dogs, a condition often fatal. The study aimed to compare two surgical techniques for gastropexy: the classical incisional gastropexy through a midline approach and the endoscopy-guided percutaneous gastropexy, to identify the least invasive and most effective method for fixing the most mobile part of the stomach.
The research involved 16 dogs, divided into two groups of 8. The first group underwent classical incisional gastropexy, while the second group was treated with endoscopy-guided percutaneous gastropexy. The techniques were compared in terms of efficacy, invasiveness, and impact on the animal's recovery and overall well-being.

The results showed that the endoscopy-guided percutaneous gastropexy is a highly recommended technique due to its minimally invasive nature and effective stomach fixation. However, its adoption is limited by the high cost of endoscopic equipment and the need for specialized training to perform the procedure. These factors make the classical incisional gastropexy a more accessible option in many contexts, despite being more invasive.