bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stabilized Performance Maximization for GAN-based Real-Time Authentication Image Generation over Internet
Authors: Shim Joo Yong , Jung Soyi , Kim Joongheon , Kim Jong-Kook 
Published: July 2023

AbstractProviding the completely automated public test to tell computers and humans apart (CAPTCHA) services that are not vulnerable to learning is an important issue. Image-based CAPTCHA services have strengthened authentication by taking advantage of the fact that it is more difficult for computers to understand images, but the rapid growth of deep learning has made it possible to break and attack authentication. Image-based CAPTCHA uses pre-stored data, which enables learning and results in vulnerability. This paper presents an adaptive generative adversarial network (GAN) selection scheme using time-average image quality maximization subject to system/buffer stability. By using GAN, it can generate and provide new images for CAPTCHA authentication every time, preventing deep learning from learning images and enhancing security. In the image generation process, the trade-off exists between image quality and generation time, and in consideration of this trade-off, delay aware image-based authentication Lyapunov-based algorithm is proposed for stable and maximized performance. Moreover, through the performance evaluation, we investigate and show the existence of trade-off between generation time and generated image quality in the image generation process in both quantitative and qualitative manner.
Opioid, sedative, preadmission medication and iatrogenic withdrawal risk in UK adult critically ill patients: a point prevalence study
Authors: Eadie Rebekah , McKenzie Cathrine A. , Hadfield Daniel , Kalk Nicola J. , Bolesta Scott , Dempster Martin , McAuley Daniel F. , Blackwood Bronagh ,   UK ALERT-ICU study investigators
Published: July 2023

Abstract
Background
Iatrogenic withdrawal syndrome, after exposure medication known to cause withdrawal is recognised, yet under described in adult intensive care.

Aim
To investigate, opioid, sedation, and preadmission medication practice in critically ill adults with focus on aspects associated with iatrogenic withdrawal syndrome.

Method
One-day point prevalence study in UK intensive care units (ICUs). We collected ICU admission medication and/or substances with withdrawal potential, sedation policy, opioid and sedative use, dose, and duration.

Results
Thirty-seven from 39 participating ICUs contributed data from 386 patients. The prevalence rate for parenteral opioid and sedative medication was 56.1% (212 patients). Twenty-three ICUs (59%) had no sedation/analgesia policy, and no ICUs screened for iatrogenic withdrawal. Patient admission medications with withdrawal-potential included antidepressants or antipsychotics (43, 20.3%) and nicotine (41, 19.3%). Of 212 patients, 202 (95.3%) received opioids, 163 (76.9%) sedatives and 153 (72.2%) both. Two hundred and two (95.3%) patients received opioids: 167 (82.7%) by continuous infusions and 90 (44.6%) patients for longer than 96-h. One hundred and sixty-three (76.9%) patients received sedatives: 157 (77.7%) by continuous infusions and 74 (45.4%) patients for longer than 96-h.

Conclusion
Opioid sedative and admission medication with iatrogenic withdrawal syndrome potential prevalence rates were high, and a high proportion of ICUs had no sedative/analgesic policies. Nearly half of patients received continuous opioids and sedatives for longer than 96-h placing them at high risk of iatrogenic withdrawal. No participating unit reported using a validated tool for iatrogenic withdrawal assessment.
Effectiveness and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and advanced kidney disease
Authors: Hsu Chia-Chen , Chen Cheng-Chi , Chou Chian-Ying , Chen Kuan-Hsuan , Wang Sheng-Fan , Chang Shih-Lin , Chang Yuh-Lih 
Published: July 2023

Abstract
Background
The effectiveness and safety of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) and advanced kidney disease (AKD) has not been fully established.

Objectives
To determine the effectiveness and safety related to pooled or specific DOACs to that with warfarin in patients with AF and AKD.

Methods
Patients with AF and AKD (estimated glomerular filtration rate < 30 mL/min) who received DOAC or warfarin from July 2011 to December 2020 were retrospectively identified in a medical center in Taiwan. Primary outcomes were hospitalized for stroke/systemic embolism and major bleeding. Secondary outcomes included any ischemia and any bleeding.

Results
A total of 1,011 patients were recruited, of whom 809 (80.0%) were in the DOACs group (15.3% dabigatran, 25.4% rivaroxaban, 25.2% apixaban, and 14.1% edoxaban), and 202 (20.0%) in the warfarin group. DOACs had considerably lower risks of stroke/systemic embolism (adjusted hazard ratio [aHR] 0.29; 95% CI, 0.09–0.97) and any ischemia (aHR, 0.42; 95% CI, 0.22–0.79), but had comparable risks of major bleeding (aHR, 0.99; 95% CI, 0.34–2.92) and any bleeding (aHR, 0.74; 95% CI, 0.50–1.09) than warfarin. Apixaban was linked to considerably lower risks of any ischemia (aHR, 0.13; 95% CI, 0.04–0.48) and any bleeding (aHR, 0.53; 95% CI, 0.28–0.99) than warfarin.

Conclusion
Among patients with AF and AKD, DOACs were linked to a lower risk of ischemic events, and apixaban was linked to a lower risk of any ischemia and any bleeding than warfarin.
Role of metabolomic profile as a potential marker to discriminate membranous nephropathy from IgA nephropathy
Authors: Qu Yuchen , Wang Yueyuan , Hu Zhanhong , Su Cunjin , Qian Chenyue , Pan Jie , Zhu Ye , Shi Aiming 
Published: July 2023

Abstract
Background
Membranous nephropathy (MN) and IgA nephropathy (IgAN) are the most common primary glomerulopathies worldwide. The systemic metabolic changes in the progression of MN and IgAN are not fully understood.

Methods
A total of 87 and 70 patients with MN and IgAN, respectively, and 30 healthy controls were enrolled in this study. Untargeted metabolomics was performed to explore the differential metabolites and metabolic pathways in the early stage of MN and IgAN. To judge the diagnostic ability of biomarkers, receiver operating characteristic curve analysis (ROC) were performed.

Results
Principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) suggested that patients with MN and IgAN showed an obvious separation trend from the healthy controls. In addition, 155 and 148 metabolites were identified to be significantly altered in the MN and IgAN groups, respectively. Of these, 70 metabolites were markedly altered in both disease groups; six metabolites, including L-tryptophan, L-kynurenine, gamma-aminobutyric acid (GABA), indoleacetaldehyde, 5-hydroxyindoleacetylglycine, and N-alpha-acetyllysine, showed the opposite tendency. The most affected metabolic pathways included the amino acid metabolic pathways, citrate cycle, pantothenate and CoA biosynthesis, and hormone signaling pathways.

Conclusions
Substantial metabolic disorders occurred during the progression of MN and IgAN. L-tryptophan, L-kynurenine, GABA, indoleacetaldehyde, 5-hydroxyindoleacetylglycine, and N-alpha-acetyllysine may show potential as biomarkers for the identification of MN and IgAN.
EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report
Authors: Tattersall Luke , Agrawal Ankita , Adinolfi Elena , Gartland Alison 
Published: July 2023

AbstractThe inaugural meeting of the EU COST Action CA21130 PRESTO was held in February 2023, at the University of Ferrara, Italy. Our meeting report provides an overview of PRESTO, a tribute to Professor Jim Wiley, overviews of the talk, and a speaker synopsis that discusses the resources, models, equipment, and techniques available in different lab groups throughout Europe, increasing the prospect of collaborative research.
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytes
Authors: Kesavan Jaideep , Watters Orla , de Diego-Garcia Laura , Méndez Aida Menéndez , Alves Mariana , Dinkel Klaus , Hamacher Michael , Prehn Jochen H. M. , Henshall David C. , Engel Tobias 
Published: July 2023

AbstractActivation of the ATP-gated P2X7 receptor (P2X7R), implicated in numerous diseases of the brain, can trigger diverse responses such as the release of pro-inflammatory cytokines, modulation of neurotransmission, cell proliferation or cell death. However, despite the known species-specific differences in its pharmacological properties, to date, most functional studies on P2X7R responses have been analyzed in cells from rodents or immortalised cell lines. To assess the endogenous and functional expression of P2X7Rs in human astrocytes, we differentiated human-induced pluripotent stem cells (hiPSCs) into GFAP and S100 β-expressing astrocytes. Immunostaining revealed prominent punctate P2X7R staining. P2X7R protein expression was also confirmed by Western blot. Importantly, stimulation with the potent non-selective P2X7R agonist 2′,3′-O-(benzoyl-4-benzoyl)-adenosine 5′- triphosphate (BzATP) or endogenous agonist ATP induced robust calcium rises in hiPSC-derived astrocytes which were blocked by the selective P2X7R antagonists AFC-5128 or JNJ-47965567. Our findings provide evidence for the functional expression of P2X7Rs in hiPSC-derived astrocytes and support their in vitro utility in investigating the role of the P2X7R and drug screening in disorders of the central nervous system (CNS).
A qualitative study exploring the experiences and perspectives of patients with cancer attending a 12-week exercise program
Authors: Borsati Anita , Marotta Angela , Ducoli Valentina , Dodi Alessandra , Belluomini Lorenzo , Schena Federico , Milella Michele , Pilotto Sara , Lanza Massimo , Avancini Alice 
Published: July 2023

Abstract
Purpose
Physical activity is associated with a reduction in mortality and recurrence risks in patients with cancer. Despite the well-recognized benefits of exercise, patients’ adherence to an exercise program remains a challenge. The present study aimed to assess the experiences of patients with cancer participating in a 12-week exercise program.

Methods
A total of 21 survivors participated in focus group discussions after the conclusion of the exercise intervention. Semi-structured interview questions were developed according to the theory of the Health Belief Model. Data were analyzed using thematic analysis and categorized into perceived benefits, barriers, and cues to action.

Results
Patients described a series of benefits achieved during the exercise program, from physical to psychological domains. Treatment-related side effects and logistic factors, including distance from the gym facility, were the most commonly reported barriers to adherence. Concerning cues to action, expected benefits from exercise were the most important reason to participate, while a patient-center program, supervised by skilled experts, highly stimulated patients to complete the program.

Conclusion
Overall, patients with cancer reported a positive experience participating in a supervised exercise program. A variety of factors influencing participation and adherence were individuated. This study may help design and develop effective and sustainable programs addressing individuals’ needs.
Optimizing total ammonia–nitrogen concentration for enhanced microbial fuel cell performance in landfill leachate treatment: a bibliometric analysis and future directions
Authors: Ishaq Aliyu , Said Mohd Ismid Mohd , Azman Shamila Binti , Abdulwahab Mohd Firdaus , Jagun Zainab Toyin 
Published: July 2023

AbstractUntreated landfill leachate can harm the environment and human health due to its organic debris, heavy metals, and nitrogen molecules like ammonia. Microbial fuel cells (MFCs) have emerged as a promising technology for treating landfill leachate and generating energy. However, high concentrations of total ammonia–nitrogen (TAN), which includes both ammonia and the ammonium ion, can impede MFC performance. Therefore, maintaining an adequate TAN concentration is crucial, as both excess and insufficient levels can reduce power generation. To evaluate the worldwide research on MFCs using landfill leachate as a substrate, bibliometric analysis was conducted to assess publication output, author-country co-authorship, and author keyword co-occurrence. Scopus and Web of Science retrieved 98 journal articles on this topic during 2011–2022; 18 were specifically evaluated and analysed for MFC ammonia inhibition. The results showed that research on MFC using landfill leachate as a substrate began in 2011, and the number of related papers has consistently increased every 2 years, totaling 4060 references. China, India, and the USA accounted for approximately 60% of all global publications, while the remaining 40% was contributed by 70 other countries/territories. Chongqing University emerged as one of the top contributors among this subject’s ten most productive universities. Most studies found that maintaining TAN concentrations in the 400–800 mg L−1 in MFC operation produced good power density, pollution elimination, and microbial acclimatization. However, the database has few articles on MFC and landfill leachate; MFC ammonia inhibition remains the main factor impacting system performance. This bibliographic analysis provides excellent references and future research directions, highlighting the current limitations of MFC research in this area.
Sewage sludge pretreatment: current status and future prospects
Authors: Ćwiertniewicz-Wojciechowska Magdalena , Cema Grzegorz , Ziembińska-Buczyńska Aleksandra 
Published: July 2023

AbstractSewage sludge is regarded by wastewater treatment plants as problematic, from a financial and managerial point of view. Thus, a variety of disposal routes are used, but the most popular is methane fermentation. The proportion of macromolecular compounds in sewage sludges varies, and substrates treated in methane fermentation provide different amounts of biogas with various quality and quantity. Depending on the equipment and financial capabilities for methane fermentation, different methods of sewage sludge pretreatment are available. This review presents the challenges associated with the recalcitrant structure of sewage sludge and the presence of process inhibitors. We also examined the diverse methods of sewage sludge pretreatment that increase methane yield. Moreover, in the field of biological sewage sludge treatment, three future study propositions are proposed: improved pretreatment of sewage sludge using biological methods, assess the changes in microbial consortia caused with pretreatment methods, and verification of microbial impact on biomass degradation.
Concomitant evaluation of cardiovascular and cerebrovascular controls via Geweke spectral causality to assess the propensity to postural syncope
Authors: Porta Alberto , Gelpi Francesca , Bari Vlasta , Cairo Beatrice , De Maria Beatrice , Tonon Davide , Rossato Gianluca , Faes Luca 
Published: July 2023

AbstractThe evaluation of propensity to postural syncope necessitates the concomitant characterization of the cardiovascular and cerebrovascular controls and a method capable of disentangling closed loop relationships and decomposing causal links in the frequency domain. We applied Geweke spectral causality (GSC) to assess cardiovascular control from heart period and systolic arterial pressure variability and cerebrovascular regulation from mean arterial pressure and mean cerebral blood velocity variability in 13 control subjects and 13 individuals prone to develop orthostatic syncope. Analysis was made at rest in supine position and during head-up tilt at 60°, well before observing presyncope signs. Two different linear model structures were compared, namely bivariate autoregressive and bivariate dynamic adjustment classes. We found that (i) GSC markers did not depend on the model structure; (ii) the concomitant assessment of cardiovascular and cerebrovascular controls was useful for a deeper comprehension of postural disturbances; (iii) orthostatic syncope appeared to be favored by the loss of a coordinated behavior between the baroreflex feedback and mechanical feedforward pathway in the frequency band typical of the baroreflex functioning during the postural challenge, and by a weak cerebral autoregulation as revealed by the increased strength of the pressure-to-flow link in the respiratory band. GSC applied to spontaneous cardiovascular and cerebrovascular oscillations is a promising tool for describing and monitoring disturbances associated with posture modification.
Graphical Abstract
Characterization of Gas-Atomized Equiatomic AlCoCrFeNi Powder for Additive Manufacturing
Authors: Karimi J. , Kollo L. , Prashanth K. G. 
Published: July 2023

Abstract
The powder particle properties in additive manufacturing processes such as selective laser melting (SLM) influence the material properties. The microstructure, hardness, and chemical composition of gas-atomized AlCoCrFeNi powder particles were investigated, which showed a biphasic structure, consisting of FCC and BCC with a significant deviation in hardness. SLMed samples, consisting of BCC phase, indicated poor printability, inhomogeneous microstructure, and cracks. Microstructural inhomogeneity of SLM AlCoCrFeNi parts must reflect the inhomogeneity inherited from the atomized powder.

Graphical Abstract
Visual rating and the use of image analysis for assessing canopy density in a pecan provenance collection during leaf fall
Authors: Pisani Cristina , Bock Clive H. , Randall Jennifer 
Published: July 2023

AbstractA collection representing the native range of pecan was planted at the USDA − ARS Southeastern Fruit and Tree Nut Research Station, Byron, GA. The collection (867 trees) is a valuable genetic resource for characterizing important horticultural traits. Canopy density during leaf fall is important as the seasonal canopy dynamics provides insights to environmental cues and breeding potential of germplasm. The ability of visual raters to estimate canopy density on a subset of the provenance collection (76 trees) as an indicator of leaf shed during autumn along with image analysis values was explored. Mean canopy density using the image analysis software was less compared to visual estimates (11.9% vs 18.4%, respectively). At higher canopy densities, the raters overestimated foliage density, but overall agreement between raters and measured values was good (ρc = 0.849 to 0.915), and inter-rater reliability was high (R2 = 0.910 to 0.953). The provenance from Missouri (MO-L), the northernmost provenance, had the lowest canopy density in November, and results show that the higher the latitude of the provenance, the lower the canopy density. Based on regression, the source provenance latitude explained 0.609 of the variation using image analysis, and 0.551 to 0.640 when based on the rater estimates of canopy density. Visual assessment of pecan canopy density due to late season leaf fall for comparing pecan genotypes provides accurate and reliable estimates and could be used in future studies of the whole provenance collection.
Establishment of a successful robotic pediatric general surgery practice
Authors: Raymond Steven L. , Sharafeddin Fransua , Sacks Marla A. , Srikureja Daniel , Gomez Nephtali , Moores Donald , Radulescu Andrei , Khan Faraz A. , Tagge Edward P. 
Published: July 2023

AbstractRobotic-assisted surgery (RAS) has a variety of theoretical advantages, including tremor filtration, optimal visualization, and improvement of surgeon ergonomics. Though it has achieved wide application in pediatric urology, the majority of pediatric general surgeons do not employ RAS. This study reports our institution’s experience with RAS on a pediatric general surgery team. Following IRB approval, a retrospective review of all pediatric patients at our academic children’s hospital who underwent RAS between 2017 and 2022 for pediatric general surgical conditions was performed. Patient demographics, operation performed, operating time, complications, and recovery were evaluated. A total of 159 children underwent RAS, increasing from 10 patients in 2017 to 59 patients in 2022. The median age and weight were 15.3 years and 76.4 kg, and 121 (76.1%) were female. The application of RAS was successful in all cases. There were no intraoperative complications and no conversions to an open approach. Eleven patients (6.9%) had unplanned presentations to the emergency department within 30 days. Five of these patients (3.1%) required admission to the hospital. This study demonstrates that the application of RAS in an academic pediatric general surgery practice is feasible and safe. The application of RAS to pediatric general surgery should continue to increase as operative teams increase their experience and comfort.Level of evidence Level IV.
Evaluation of simple diagnostic parameters in acute kidney injury in hospitalized patients—diagnostic recommendations for non-nephrologists
Authors: Buckenmayer Anna , Siebler Nadja , Haas Christian S. 
Published: July 2023

AbstractAcute kidney injury (AKI) is very common in hospitalized patients, affecting patient’s mortality and morbidity. Major causes are prerenal AKI and acute tubular necrosis (ATN). Even though a variety of parameters/indices exist, their reliability and practicability are controversial: in fact, there is a need for a simple diagnostic approach for AKI in in-patients with parameters easily obtained in any hospital. The objective of the study was: (1) to assess reliability of simple laboratory parameters/indices to differentiate pre-/intrarenal AKI; (2) to evaluate the most reliable and feasible parameters/indices; and (3) to identify the possible impact of confounding factors. Retrospectively, in-patients with AKI hospitalized in 2020 in a university nephrology department were included. Spot urine and 24-h collection urine was analyzed with urine sodium (UNa), urine specific gravity (USG), fractional excretion of sodium (FENa), fractional excretion of urea (FEUrea), urine osmolality (UOsm), urine to plasma creatinine ratio (UCr/PCr) and renal failure index (RFI). Overall, 431 patients were included. UNa, UOsm, USG and RFI showed high specificity > 85% for prerenal AKI, UNa and RFI provided good specificity for ATN. Loop diuretics, ACE inhibitors/AT1 blockers or pre-existing chronic kidney disease had no impact. In patients with AKI, UNa, USG and RFI: (1) proved to be very specific for prerenal AKI and showed high sensitivity for ATN; (2) can be easily determined using serum and spot urine; and (3) are not confounded by medication or comorbidities. These parameters/indices are helpful to identify the aetiology of AKI and to guide therapy, thereby improving patients’ safety and outcome.