bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic association between the APOE ε4 allele, toxicant exposures and Gulf War Illness diagnosis
Authors: Abdullah Laila , Nkiliza A , Niedospial D , Aldrich G , Bartenfelder G , Keegan A , Hoffmann M , Mullan M , Klimas N , Baraniuk J , Crawford F , Krengel M , Chao L , Sullivan K 
Published: April 2023

Abstract
Introduction: Exposure to nerve agents, pyridostigmine bromide (PB), pesticides, and oil-well fires during the 1991 Gulf War (GW) are major contributors to the etiology of Gulf War Illness (GWI). Since the apolipoprotein E (APOE) ε4 allele is associated with the risk of cognitive decline with age, particularly in the presence of environmental exposures, and cognitive impairment is one of the most common symptoms experienced by veterans with GWI, we examined whether the ε4 allele was associated with GWI.
Methods: Using a case-control design, we obtained data on APOE genotypes, demographics, and self-reported GW exposures and symptoms that were deposited in the Boston Biorepository and Integrative Network (BBRAIN) for veterans diagnosed with GWI (n = 220) and healthy GW control veterans (n = 131). Diagnosis of GWI was performed using the Kansas and/or Center for Disease Control (CDC) criteria.
Results: Age- and sex-adjusted analyses showed a significantly higher odds ratio for meeting the GWI case criteria in the presence of the ε4 allele (Odds ratio [OR] = 1.84, 95% confidence interval [CI = 1.07 – 3.15], p ≤ 0.05) and with two copies of the ε4 allele (OR = 1.99, 95% CI [1.23 - 3.21], p ≤ 0.01). Combined exposure to pesticides and PB pills (OR = 4.10 [2.12-7.91], p ≤ 0.05) as well as chemical alarms and PB pills (OR = 3.30 [1.56-6.97] p ≤ 0.05) during the war were also associated with a higher odds ratio for meeting GWI case criteria. There was also an interaction between the ε4 allele and exposure to oil well fires (OR = 2.46, 95% CI [1.07-5.62], p ≤ 0.05) among those who met the GWI case criteria.
Conclusion: These findings suggest that the presence of the ε4 allele was associated with meeting the GWI case criteria. Gulf War veterans who reported exposure to oil well fires and have an ε4 allele were more likely to meet GWI case criteria. Long-term surveillance of veterans with GWI, particularly those with oil well fire exposure, is required to better assess the future risk of cognitive decline among this vulnerable population.
The assessment of the associated factors of Emotional divorce among Iranian couples during the Covid19 Pandemic: A descriptive study
Authors: Sadeghzadeh Zahra , Ghodssi-ghassemabad Robabeh , Hamdieh Mostafa , Shariatpanahi Samirasadat , babazadeh faeze , Abdoli Mitra , gelehkolaee Keshvar samadaee 
Published: April 2023

Abstract
Background: Emotional divorce can be defined as an important factor in the boredom of the couple, the cooling of the relationship between them, the feeling of sadness and despair, and the lack of dependence of the couple on each other, which has irreparable consequences for the family. Therefore, the present study was designed to assess the affecting associated factors of emotional divorce among Iranian couples during the Covid19 pandemic.
Methods: A descriptive-analytical study was performed on 900 men and women from 22 districts of Tehran who were selected by the available sampling methods from March to October 2021. Data collection tools are Guttmann demographic and Emotional Divorce Questionnaires. The Questionnaires were completed by the participants of the study. R 4.0.2 software was used to analyze the data, in addition, an independent t-test and chi-square were used to compare the subjects in terms of the emotional divorce. Also, the multiple logistic regression method was used to determine the independent factors affecting emotional divorce.
Results: The results showed that the associated factors of emotional divorce include age, marriage rank, duration of the marriage, choosing the spouse by parents, the education level of the couple, the job of the couple, infection of Covid19, and having disputes before Covid19 infection outbreak.
Conclusion: Emotional divorce is considered as a social harm which could be the prelude of legal divorce. Therefore, the study of affecting factors on it in any society can pave the way for culture-based interventions to reduce such social harms.
Virtual Education as an Academic Model in the Use of Medical Cannabis in Colombia
Authors: Bermúdez-Ocampo Juan S. , Zapata Juan P , Zuluaga Andrés F 
Published: April 2023

Abstract
Background: There is a global tendency to decriminalize the use of cannabis, either medical or recreational. Colombia is no exception and from 2016 it has been legal to produce and prescribe medical cannabis. Nonetheless, like it has happened in other countries, there appears to be neglect to medical education on the subject.
Methods: A Situational analysis was conducted, in which bibliography sources were revised, a survey and questionnaire were conducted, a focus group was developed, a normogram designed and available courses were revised.
Results: The legal framework facilitates the production and prescription of medical cannabis, the survey, the questionnaire, and the focus group all converged on the fact that medical education is not adequate and guidelines for an adequate course were proposed, the courses available did not meet the quality criteria established.
Conclusions: Even though Colombia has the legal framework to produce and prescribe medical cannabis, its doctors are not prepared academically to do so. This subject should be strengthened and included in the medical pensum of the different local universities.
Allogeneic hematopoietic stem cell transplantation and pre-transplant strategies in patients with NPM1-mutated acute myeloid leukemia – a single center experience –
Authors: Jäger Paul , Rautenberg Christina , Kaivers Jennifer , Kasprzak Annika , Geyh Stefanie , Baermann Ben-Niklas , Haas Rainer , Germing Ulrich , Schroeder Thomas , Kobbe Guido 
Published: April 2023

Abstract
Patients with acute myeloid leukemia (AML) and nucleophosmin 1 gene mutations (NPM1mut) show a favorable prognosis with chemotherapy (CT) in the absence of negative prognostic genetic abnormalities. Between 2008 and 2021 64 patients with NPM1mutAML received alloHSCT because of additional adverse prognostic factors (1st line), inadequate response to or relapse during or after CT (2nd line). To expand the evidence in alloTX in NPM1mut AML, clinical and molecular data were retrospectively analyzed with respect to pre-transplant strategies and outcome. Patients with minimal residual disease negative (MRD-) CR at transplant had better 2-y-PFS and 2-y-OS (77% and 88%) than patients with minimal residual disease positive (MRD+) CR (41% and 71%) or patients with active disease (AD) at transplant (20% and 52%). The 2nd line patients with relapse after completing CT responded well to high dose cytarabine based salvage chemotherapy (salvage CT) in contrast to patients relapsing while still on CT (90% vs 20%, p = 0.0170). 2-y-PFS and 2-y-OS was 86% in patients who achieved a 2nd MRD- CR pre alloHSCT. Outcome in NPM1mutAML depends on disease burden at alloHSCT. Time and type of relapse in relation to CT are predictive for response to salvage CT.
Relapse rate and predictors of relapse after cessation of glucocorticoid maintenance therapy in type 1 autoimmune pancreatitis: a multicenter retrospective study
Authors: Kiyoshita Yusuke , Ishii Yasutaka , Serikawa Masahiro , Hanada Keiji , Sasaki Tamito , Fujimoto Yoshifumi , Yamaguchi Atsushi , Hirao Ken , Noma Bunjiro , Minami Tomoyuki , Okazaki Akihito , Yukutake Masanobu , Mouri Teruo , Tsuboi Tomofumi , Tatsukawa Yumiko , Nakamura Shinya , Hirano Tetsuro , Ikemoto Juri , Saeki Sho , Tamura Yosuke , Miyamoto Sayaka , Furukawa Masaru , Nakmura Kazuki , Yamashita Yumiko , Iijima Noriaki , Oka Shiro 
Published: April 2023

Abstract
Background:
Type 1 autoimmune pancreatitis responds well to glucocorticoid therapy with a high remission rate. Moreover, glucocorticoid maintenance therapy can help prevent relapse. However, the relapse rate following cessation of long-term glucocorticoid therapy is unknown. The aim of this study was to clarify the relapse rate and predictors of relapse following long-term glucocorticoid therapy cessation.
Methods:
We analyzed 94 patients who achieved remission after undergoing glucocorticoid therapy, discontinued treatment after at least 6 months of maintenance therapy, and were subsequently followed up for at least 6 months. The patients were divided into three groups based on treatment duration (< 18, 18–36, and ≥ 36 months), and their relapse rates were compared. Univariate and multivariate analyses of clinical factors were conducted to identify relapse predictors.
Results:
After discontinuing glucocorticoid therapy, relapse was observed in 43 (45.7%) patients, with cumulative relapse rates of 28.2% at 1 year, 42.1% at 3 years, 47.0% at 5 years, and a plateau of 77.6% at 9 years. Of the 43 patients who relapsed, 25 (58.1%) relapsed within 1 year after after cessation of glucocorticoid therapy. Relapse and cumulative relapse rates did not differ significantly according to treatment duration. In the multivariate analysis, an elevated serum IgG4 level at the time of glucocorticoid cessation was found to be an independent predictor of relapse (hazard ratio, 3.351; p = 0.005).
Conclusions:
A high relapse rate occurred after cessation of glucocorticoid maintenance therapy, regardless of the duration of maintenance therapy, especially within the first year after cessation. However, the normalization of long-term serum IgG4 levels may be a factor in considering cessation.
WITHDRAWN: Effect of Hypothalamic Adrenal Axis and Thyroid Function Alterations on Prognosis of Critically Ill Covid-19 Patients
Authors: Korkusuz Muhammet , Karaburgu Sulbiye , Et Tayfun , Yarımoglu Rafet , Kumru Nuh 
Published: April 2023

Abstract
Purpose: The aim of this study was to evaluate the changes in adrenal, and thyroid functions on the prognosis of COVID-19 patients admitted to the intensive care unit (ICU).
Methods:This was a retrospective evaluation that included COVID-19 patients requiring ICU admission. Serum cortisol, adrenocorticotrophic hormone (ACTH), thyroid-stimulating hormone (TSH), free thyroxine (fT4) and triiodothyronine (fT3) levels were measured on admission and two more times during the hospitalization. Routine biochemistry, hemogram, C-reactive protein, procalcitonin, fibrinogen and D-dimer levels were also measured, along with hormones.All-cause mortality during ICU stay, inotropic drug and mechanical ventilation needs, and duration of hospitalization were recorded for each patient. Euthyroid sick syndrome (ESS) and hypocortisolism rates were determined. Deceased and survivor patients were compared in terms of hormone values, and logistic regression to determine independent associates of mortality were performed.
Results: Overall, 124 patients (58% male, mean age 70.7±11.3 years) were included. During the ICU stay, both fT3 and fT4, but not TSH, showed a statistically significant decrease compared to admission values. Serum cortisol and ACTH values increased compared to admission values, this increase was not significant. ESS was present in 89.5% of the patients. Two-thirds of the patients died in ICU. Serum fT3 values were significantly lower among decedents compared to survivors. Hypocortisolism was detected in 20.1% of the patients. Only the fT3 level could independently and significantly predict all-cause mortality.
Conclusion:ESS was almost universal among critically ill COVID-19 patients. Serum fT3, but not other thyroid or adrenal hormones, could significantly predict all-cause mortality.
Trial registration number: 02-2020/04
Date of registration: 07/12/2020
Mitochondrial Health Index Correlates with Plasma Circulating Cell-Free Mitochondrial DNA in Bipolar Disorder
Authors: Scaini Giselli , Cordeiro Rafaela , Lima Camila Carvalho , Fries Gabriel , Zunta-Soares Giovana , Soares Jair C. , de Quevedo Joao 
Published: April 2023

Abstract
Background: Although mitochondria dysfunction is known to play an essential role in the pathophysiology of bipolar disorder (BD), there is a glaring gap in our understanding of how mitochondrial dysfunction can modulate clinical phenotypes. This study aimed to evaluate the composite mitochondrial health index (MHI) in BD subjects and non-psychiatry controls (Non-psychiatry controls). We will also explore whether lower MIH will be related to higher cell-free mtDNA (ccf-mtDNA) levels and poor clinical outcomes.
Methods: Fourteen BD-I patients and 16 age- and sex-matched non-psychiatry controls were enrolled for this study. Peripheral blood mononuclear cells (PBMCs) were used to measure the enzymatic activities of citrate synthase and complexes I, II, and IV and mtDNA copy number. ccf-mtDNA was evaluated by qPCR in plasma. Mitochondrial quality control (MQC) proteins were evaluated by western blotting.
Results: One-Way ANCOVA after controlling for age, sex, body mass index (BMI), and smoking status showed that patients with BD present a decrease in the MHI compared to non-psychiatry controls, and higher ccf-mtDNA levels, which was negatively correlated with MHI. Because the MQC network is essential to maintain mitochondrial health, we also evaluated the relationship between MQC-related proteins with MHI and ccf-mtDNA. Our results showed that MHI negatively correlated with Fis-1 and positively with Opa-1 and LC3. Moreover, we found a negative correlation between ccf-mtDNA, Opa-1, and LC3 and a positive correlation between cff-mtDNA and Fis-1. Finally, we found that subjects with longer illness duration, higher depressive symptom scores, and worse functional status had lower MHI and higher ccf-mtDNA.
Conclusion: In summary, the present findings corroborate previous studies and provide strong support for the hypothesis that mitochondrial regulation and function are integral parts of the pathogenesis of BD.
Prototypical Latent Space Regularization for Improved Reconstruction Quality in Variational Autoencoders
Authors: Oliveira Dario Augusto Borges , Rosa Laura Elena Cue La 
Published: April 2023

Abstract

Variational autoencoders use latent space regularization with known distributions to facilitate stochastic synthesis via simple sampling procedures. However, existing regularization approaches often struggle to balance regularization and reconstruction quality effectively. To address this, we propose a distributed latent space regularization approach using prototypical deep clustering with known distributions. Our method achieves high-quality data synthesis by decoding samples around prototypes, without the need for auxiliary networks to explicitly learn decoder synthesis from codes. Our approach enables obtaining an appropriate number of clusters for solid regularization with better reconstruction quality and improved synthesis control. Through widespread exploratory benchmarks, we demonstrate that our regularization centered on optimal prototypes' coordinates or cluster centroids neutralizes the adverse effects of regularization terms on autoencoder reconstruction quality, matching non-regularized autoencoders' performance. Additionally, we report promising results for interpreting data representatives via simple prototype synthesis and controlling the synthesis of samples with prototype-like characteristics by decoding noise around prototype coordinates using known distributions.
Ceramic Art Image Design Based on Neural Network and Particle Image Algorithm
Authors: Zhang Lijian , Liu Guangfu 
Published: April 2023

Abstract
In recent years, scientists have developed a new type of algorithm called convolutional neural network algorithm in the field of neural networks. This algorithm not only has a powerful image recognition function, but also can distinguish and arrange data images. At the same time, the algorithm's recognition and processing functions are also very powerful, able to identify relatively hidden images and process a very large image library in a short time. The research content of this article is the application and development of ceramic image creation based on the classification effect of neural network and the characteristics of quantum particle swarm algorithm. And according to the principles, standards, characteristics of neural network classification and the characteristics and technology of particle swarm algorithm, the traditional LB G algorithm and an improved LB G algorithm are discussed, and simulation experiments are carried out. During the experiment, the staff analyzed and optimized the specific process of the quantum particle swarm algorithm through a large number of calculations and simulation experiments. And according to the classification of neural network and quantum particle swarm algorithm, the researchers also proposed a set of practical ceramic image design methods. Through the inspection and comparison of the design results, the researchers preliminarily judged that the design method is not only practical, but also high Many advantages such as recognition, high accuracy and good visual experience. At the same time, the staff also optimized the method based on the preliminary design results.
Environmental Resource Allocation and Online English Teaching Based on Voice Dialogue System
Authors: Wang Panpan 
Published: April 2023

Abstract
In speech conversation systems, the specific distribution of computing resources is very complex, and resource requirements exhibit dynamic changes. If the evaluation of customer needs is too low, computing resources cannot complete the work proposed by the customer; If customer demand is overestimated, many computing resources are wasted and idle, and a reasonable environmental resource allocation algorithm is the top priority in solving the problem. As mankind enters the information modernization society, multimedia technology and Internet technology are increasingly being widely used in various fields of society, including online teaching. In lifelong learning systems, online English teaching is now an essential learning method. However, online learning has been widely used in the world. When engaging in online learning activities, it is found that there are insufficient systematic research and low participation in learning. People can access a large number of very rich learning resources on the Internet. In the online learning process, learners can fully exert their autonomy and initiative to cultivate and expand their own innovation and practical abilities. When participating in the learning process of online courses, learners can not only develop themselves, but also strengthen effective coordination and communication with others and society, enabling them to coordinate the development of all aspects of their own abilities, improving learning effectiveness and efficiency. This article aims to promote the better development of online English teaching through the research on environmental resource allocation based on voice dialogue systems and its application to online English teaching.
Cloud computing-based online video sports course management
Authors: Liu Qiao 
Published: April 2023

Abstract
This paper designs a kind of effective online video system by introducing cloud computing technology into the field of sports course management. The main idea is to use the attention network mechanism to obtain the characteristics of the target course and use the recommendation algorithm to calculate the accurate recommendation for the user. In this process, the course vector and user features obtained through the model can be stored and compiled by the system, and a course recommendation system database can be constructed. Then, a system engine is designed based on clustering implicit vectors and course data, which can make personalized recommendation based on different application scenarios and users, thus providing data support for system course recommendation. Finally, the platform requirements of online video teaching practice are investigated, and the demonstration object of online teaching practice is proposed; The system is mainly equipped with user information and authority management, live video teaching management and video-on-demand teaching management, teaching video album management, teaching evaluation online course management, teaching and research interaction, examination management and other functions, and its microservice division is completed in distributed cloud computing. implemented in the service.. A series of tests have confirmed the effectiveness of the platform, which has a certain reference value for improving the effect of physical education teaching and improving the effect of students' physical education.
Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
Authors: Kise Satoko , Iijima Ayano , Nagao Chika , Okada Tadashi , Nishikawa Miyu , Ikushiro Shinichi , Nakanishi Tomoko , Sato Shigeto , Yasuda Kaori , Sakaki Toshiyuki 
Published: April 2023

Abstract
Type II rickets is a hereditary disease caused by a mutation in the vitamin D receptor (VDR) gene. The main symptoms of this disease are bone dysplasia and alopecia. Bone dysplasia can be ameliorated by high calcium intake; however, there is no suitable treatment for alopecia. In this study, we verified whether gene therapy using an adenoviral vector (AdV) had a therapeutic effect on alopecia in Vdr-KO rats. The VDR-expressing AdV was injected into six 7-week-old female Vdr-KO rats (VDR-AdV rats). On the other hand, control-AdV was injected into 7-week-old female rats (control-AdV rats); non-infected Vdr-KO rats (control rats) were also examined. The hair on the backs of the rats was shaved with hair clippers, and VDR-AdV or control-AdV was intradermally injected. Part of the back skin was collected from each rat after AdV administration. Hair follicles were observed using hematoxylin and eosin staining, and VDR expression was examined using immunostaining and western blotting. VDR-AdV rats showed significant VDR expression in the skin, enhanced hair growth, and low cyst formation, whereas control-AdV and non-infected rats did not show any of these effects. These results indicate that gene therapy is useful to treat alopecia associated with type II rickets.
‘Rebuilding Myself’- An intervention enhancing the adaptability of cancer patients to return to work: protocol of a randomized controlled trial.
Authors: Tang Jue , SANG Honghua , QUE Wenqian , ZHAO Jingyi , SU Xiaoqin , KUAI Benxin , SHI Yue , GUO Yujie 
Published: April 2023

Abstract
Aim: To describe a protocol that explores the feasibility and effectiveness of an intervention enhancing the adaptability of cancer patients to return to work.
Background: Current evidence suggests the situation of cancer patients returning to work in China is unsatisfactory. Based on the ‘Adaptation Experience and Coping Resource Model for cancer patients to return to work’, we designed an intervention protocol.
Design: A two-armed non-blinded randomized controlled trial.
Methods: 96 participants will be recruited from three hospitals and the Cancer Rehabilitation Association in Nantong. After signing the informed consent form and completing the baseline assessment questionnaire, patients will be randomly assigned to either the intervention or control group at a ratio of 1:1. The primary outcome is the adaptability to return to work. The secondary outcomes are the self-efficacy of returning to work, mental resilience, quality of life, and work ability.
Discussion: This study is to design a protocol for the ‘Rebuilding Myself’ intervention to enhance the adaptability of cancer patients to return to work. This study will provide new insights into the feasibility and effectiveness of the intervention. We anticipate that cancer patients will benefit from this study.
Impact: This study will guide for researchers to carry out interventions enhancing cancer patients’ adaptability to return to work. If proven feasible and practical, it will be carried out broadly.
Trial registration: This study was registered at the Chinese Clinical Trial Registry (Registration number: ChiCTR2200057943) on 23 March, 2022.