bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Patients Hospitalized with Neutropenic Fever and COVID-19 Infection: A Nationwide Analysis
Authors: Fatuyi Michael , Multani Maneet , Mansouri Borna , Sharath Deepali Boothankad , Feghali Joe , Olafimihan Ayobami , Elabd Hatem , Patel Anar , Alsidawi Samir 
Published: May 2023

Abstract
Importance: Neutropenic fever (NF) is an oncological emergency associated with worse outcomes. Unfortunately, there is a paucity of existing literature describing the association between neutropenic fever and COVID-19 infection.
Objective: This study investigates the effect of COVID-19 infection on outcomes of hospitalization with neutropenic fever, highlighting the patients’ characteristics.
Design: Retrospective cohort analyses were conducted using the National Inpatient Sample database year 2020.
Setting: Population-basedinpatient database in the United States
Participants: All neutropenic fever adult hospitalizations (16,790 patients) were identified from the database using ICD-10 codes and were stratified into with and without COVID-19 infection.
Main Outcomes and Measures: The primary outcome of interest was inpatient mortality. Secondary outcomes include respiratory failure, hemorrhagic shock, septic shock, acute kidney injury (AKI), health economic burden defined as longer length of stay (LOS), higher hospital cost, and patient charge.
Results: The database query generated 16,790 adult patients with a primary diagnosis of neutropenic fever. Of these, 145 patients had concurrent neutropenic fever and COVID-19 infection. Patients with neutropenic fever and COVID-19 infection had 14 times higher odds (adjusted odds ratio (AOR) = 13.6, 95% confidence interval (CI) = 3.6 – 51.8) of inpatient mortality when compared to those without COVID-19. Additionally, they had 21 times greater odds of septic shock [10.3% vs. 0.4%, aOR/aIRR = 20.8, 95% CI 4.5 – 96.5], and 11 times higher odds of respiratory failure [27.6% vs. 4.0%, aOR/aIRR = 10.6, 95% CI 4.1 – 27.5] when compared to their counterparts without COVID-19. Furthermore, these patients had longer hospital stay (9.1 vs. 5.1 days, aIRR 1.14, 95% CI 1.3–2.4), higher average hospital cost ($20,279 vs. $15,357, aIRR 1.3, 95% CI 1.1–1.7), and higher average patient charges ($96,300 vs. $57,338, aIRR 1.7, 95% CI 1.1 – 2.7)
Conclusion and Relevance: Neutropenic fever with concurrent COVID-19 infection was associated with significantly higher in-hospital mortality, greater risk of septic shock, respiratory failure, longer average hospital stay, and higher average hospital cost. Further research is needed to explore interventions to improve outcomes in hospitalized neutropenic fever patients with COVID-19. Prevention of COVID-19 infection in this population is expedient.
Water yield of mine analysis and prediction method based on EEMD-PSO- ELM-LSTM model
Authors: Zhao Zexi , Yao Xiwen , Xu Kaili , Song Jinhong , Chen Xuehui 
Published: May 2023

Abstract

In view of the complexity of mine water inflow data analysis and the uncertainty of prediction and prediction and other key issues, according to the data characteristics of metal mine water inflow, a method of mine water inflow analysis and prediction based on EEMD PSO-ELM-LSTM is proposed by applying the phase space reconstruction idea and the fusion modeling concept. Taking the monthly average water inflow of JIAOJIA Gold Mine in China from January 2014 to October 2021 as an example. Firstly, the Ensemble Empirical Mode Decomposition (EEMD) is used to decompose the measured data series of mine water inflow into trend components, seasonal components, and remainder components, and the remainder components are treated as noise and removed; Subsequently, based on the data characteristics of the decomposed component data, the PSO-ELM algorithm is selected to analyze and predict the seasonal components of water inflow, and the LSTM model is applied to analyze and predict the trend components of water inflow; Finally, the analysis and prediction results of the two are superimposed and reconstructed to obtain the final analysis and prediction results. In addition, comparative predictions were made using EEMD PSO-ELM-LSTM, LSTM, and EEMD LSTM. Compared with the independent prediction models LSTM and EEMD LSTM, the Root Mean Square Error (RMSE) of the EEMD PSO-ELM-LSTM algorithm proposed in this paper has been reduced by 248.04 and 76.27, respectively; Mean Square Error (MSE) decreased by 0.047 and 0.011, respectively; At the same time, the Nash-Sutcliffe efficiency coefficient (NSE) of the model proposed in this article is closer to 1. In summary, the EEMD PSO-ELM-LSTM mine water inflow analysis and prediction method has certain reliability and superiority, which helps to promote accurate prediction of average mine water inflow and reduce the occurrence of water inrush accidents in metal mines.
Stapler port position determination using 3-dimensional virtual simulation software in robot-assisted thoracic surgery
Authors: Hayashi Satoshi , Kawada Masaya , Mori Yuki 
Published: May 2023

Abstract
Background In robot-assisted thoracic surgery (RATS) lobectomy using a robotic stapler, stapling is difficult when the stapler port place is close to the resection target vessel. We examined whether three-dimensional computed tomography (3D-CT) software enables stapler port place determination for stapling.Methods Seventy-three patients who underwent RATS lobectomy were enrolled. The SureForm 45 Curved-Tip stapler (136 mm from the remote center to the anvil tip) was used. The virtual distance between the resection target vessel and stapler port place (VD) was preoperatively measured with 3D-CT software. The stapler port place was the most cranial intercostal space with a VD ≥ 136 mm. The actual distance between the resection target vessel and anvil tip (AD) was measured intraoperatively. We examined the associations of the difficulty in stapling with VD, AD, chest wall damage, and clinical features.Results Stapling was easier with a larger anteroposterior thoracic diameter and AD. The cut-off VD and AD for smooth stapling were 142 mm and 6 mm. Chest wall damage was frequently observed at the caudal and dorsal side ports.Conclusions As the stapler port place is located more caudally, stapling becomes easier. However, chest wall damage increases. If the stapler port place is positioned at a site ensuring VD ≥ 142 mm by 3D-CT software, smooth stapling may be possible with a decreased incidence of chest wall damage.
Optimal Trade Execution in Cryptocurrency Markets
Authors: Bundi Nils , Wei Ching-Lin , Khashanah Khaldoun 
Published: May 2023

Abstract
Novel technologies allow cryptocurrency exchanges to offer innovative services that set them apart from other exchanges. In this paper we study the distinct features of cryptocurrency fee schedules and the implications for optimal trade execution. We formulate an optimal execution strategy that minimizes the trading fees charged by the exchange. We further provide a proof for the existence of an optimal execution strategy for this type of fee schedule. In fact, the optimal strategy involves both market and limit orders on various price levels. The optimal order distribution scheme depends on the market conditions expressed in terms of the distribution of limit order execution probabilities and the exchange's specific configuration of the fee schedule. Our results indicate that a strategy kernel with an exponentially decaying allocation of trade volume to price levels further away from the best price provides a superior performance and potential reduction of trade execution cost of more than 60%. The robustness of these results is confirmed in an empirical study. To our knowledge this is the first study of optimal trade execution that takes into consideration the full fee schedule of exchanges in general.
O. volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: Results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia
Authors: Kanza Eric M , Nyathirombo Amos , Larbelee Jemmah P. , Opoku Nicholas O , Bakajika Didier K. , Howard Hayford M , Mambandu Germain L , Nigo Maurice M , Wonyarossi Deogratias Ucima , Ngave Françoise , Kennedy Kambale Kasonia , Kataliko Kambale , Bolay Kpehe M , Attah Simon K , Olipoh George , Asare Sampson , Mumbere Mupenzi , Vaillant Michel , Halleux Christine , Kuesel Annette C. 
Published: May 2023

Abstract

Background After ivermectin became available, diethylcarbamazine (DEC) use was discontinued because of severe adverse reactions, including ocular reactions, in individuals with high O. volvulus microfilaridermia. Assuming long-term ivermectin use led to < 5 microfilariae/mg skin (SmfD) with little or no eye involvement, DEC + ivermectin + albendazole treatment a few months after ivermectin was proposed. In 2018, the US FDA approved moxidectin for treatment of O. volvulus infection. The Phase 3 study evaluated ivermectin-naïve individuals with ≥ 10 SmfD for skin and ocular microfilariae and adverse events (AEs) for 12–18 months after a single treatment (8mg moxidectin, n = 978 or 150µg/kg ivermectin n = 494).Methods We descriptively analyzed the data from 1463 participants with both eyes evaluated using six (0, 1–5, 6–10, 11–20, 21–40, > 40) categories for microfilariae in the anterior chamber (mfAC) and three pre-treatment (< 20, 20-<50, ≥ 50) and post-treatment (0, > 0–5, > 5) SmfD categories. A linear mixed model evaluated factors and covariates impacting mfAC levels. Ocular AEs were summarized by type and start post-treatment. Logistic models evaluated factors and covariates impacting the risk for ocular AEs.Results Moxidectin and ivermectin had the same effect on mfAC levels. These increased from pre-treatment to Day 4 and Month 1 in 20% and 16% of participants, respectively. Six and 12 months post-treatment, mfAC were detected in ≈ 5% and ≈ 3% of participants, respectively. Ocular Mazzotti reactions occurred in 12.4% of moxidectin- and 10.2% of ivermectin-treated participants without difference in type or severity. The risk for ≥ 1 ocular Mazzotti reaction increased for women (OR 1.537, 95% CI 1.096–2.157) and with mfAC levels pre- and 4 days post-treatment (OR 0:>10 mfAC 2.704, 95% CI 1.27–5.749 and 1.619, 95% CI 0.80–3.280, respectively).Conclusions The impact of SmfD and of mfAC levels before and early after treatment on ocular AEs needs to be better understood before decisions on the risk-benefit of strategies including DEC. Such decisions should consider interindividual variability in SmfD, mfAC levels and treatment response and risks to even a small percentage of individuals.Trial registration The study was registered on 14 November 2008 in Clinicaltrials.gov (ID: NCT00790998).
The mental health impacts of fuel poverty: a scoping review protocol
Authors: Bennett Natalie C , Khavandi Sam , McColl Lewis , McGowan Victoria J 
Published: May 2023

Abstract
Objective
To map the literature base of fuel poverty and mental health, including the operationalisation of fuel poverty and the explanations given for the link between fuel poverty and mental health.
Introduction
In a context of rising fuel costs affecting nations worldwide, more people are likely to find themselves in fuel poverty. Fuel poverty is associated with detrimental physical health outcomes, but less is known about the association between fuel poverty and mental health. This review therefore aims to address this gap, by providing the first systematic identification and mapping of global research on fuel poverty and mental health.
Inclusion Criteria
We follow the Population, Concept and Context (PCC) approach to guide our inclusion criteria. Population: All children and adults (irrespective of age); Concept: the mental health impacts of fuel poverty; Context: Any country context. We will include any peer-reviewed empirical research and relevant grey literature that meet each of the PCC criteria.
Methods
We will search the following databases: Medline (Ovid), PubMed Central, APA PsychInfo (Ovid), Web of Science, Scopus, Embase (Ovid), Social Policy Practice (Ovid), Econlit (Ovid) and The Cochrane Library. We will also perform backwards citation searches and searches for grey literature. We will manage the results of the searches, screening and extraction process in the software Rayyan. The extraction domains will follow a template set out at the start of the extraction phase, and will be piloted, tailored and improved and then applied to each included record. A narrative synthesis of the extracted information from each paper will then be performed.
Криобиопсия в морфологической верификации центрального рака легких с некрозом
Authors: Mamenko I. S. , Vasilev I. V. , Belyaev G. S. , Mortada M. M. , Nefedov A. O. , Novitskaya T. A. , Yablonskiy P. K. 
Published: May 2023

Background. The diagnostic yield of a standard forceps biopsy for central lung cancer is 74 %. However, the diagnostic value is significantly reduced in the presence of necrosis in the tumor. In Russia, cryobiopsy for central lung cancer diagnosis is currently used only in a few clinical centers.The purpose of this study is to present a series of clinical cases showing the effectiveness of the cryobiopsy method in the morphological verification of central neoplasms with necrosis.Description of clinical cases. The article presents 3 clinical cases of patients with central lung cancer, in which standard forceps biopsy was ineffective due to the presence of severe necrosis in the tumor. The cryobiopsy performed at the second stage made it possible in all cases to obtain a suffcient amount of morphological material for histological and immunohistochemical studies and to reconalize the lumens of the large bronchi.Conclusion. Cryobiopsy is an effective and safe method of morphological verification of central lung cancer, which has an advantage over standard forceps biopsy, especially in the presence of a visible necrotic component in the tumor structure.
The role of ICG-fuorescence imaging in abdominal surgical oncology
Authors: Dubrovin V. Yu. , Tymchuk S. S. , Davletshina V. V. , Pavlov R. V. , Kashchenko V. A. 
Published: May 2023

The purpose of the study was to summarize and analyze the available data on modern methods of additional imaging using indocyanine green (ICG) used in abdominal surgical oncology.Material and Methods. The search and analysis of publications over the last 7–10 years was carried out using RSCI (Russian Science Citation Index), E-library, PubMed, Scopus, MedLine, Elsevier, Web of Science, ScienceDirect systems. The following keywords were used for the search: “ICG-fluorescent navigation”, “ICG-fluorescence”, “gastric cancer”, “colorectal cancer”, “indocyanine green”.Results. The role of ICG-fluorescent navigation in abdominal oncology, in particular, in surgery for cancer of the stomach, colon and rectum, identification of peritoneal carcinomatosis and liver metastases, as well as in biliary surgery and cholangiography, was shown. Intraoperative visualization of sentinel lymph nodes and mapping of lymph nodes in patients with gastric and colorectal cancers were described. In addition, the information on the diagnostic value of vascular imaging in colorectal surgery, detection of the boundaries of hepatocellular carcinoma and surrounding tissues, as well as real-time liver metastases using indocyanine green, was provided. Special attention was paid to ICG-mediated cholecystectomy and cholangiography. ICG fluorescence imaging in colorectal and gastric cancer surgery makes it possible to individualize the surgical approach and provide functional surgery associated with the performance of a sufficient and prophylactically excessive volume of surgical intervention more effectively. Conclusion. The presented data confirm the relevance of the search for a vector of improving the imaging methods used in abdominal surgical oncology, which requires even more even more multicenter prospective cohort studies to determine the best ways of improving the technique.
Experimental study of the temperature distribution in long tubular bones with a periossal arrangement of heaters
Authors: Pakhmurin D. O. , Pakhmurina V. V. , Anisenya I. I. , Sitnikov P. K. 
Published: May 2023

Purpose: to study the changes in the temperature outside and inside the long tubular bones of animals under the influence of different temperature regimes for a given time.Material and Methods. The experiments were conducted using fresh frozen pig long bones. The heating was carried out using surface heaters, the temperature of which was determined by the selected mode for 1 hour; fixation of temperature values was carried out every minute. Four heating modes were used: 3 modes of constant heating (60, 70, 80 °C) and the maximum heating mode, in which no special temperature limit was set, so heating was carried out up to 120 °C.Results. During the first 10 min of heating, a rapid rise in temperature occurred. The temperature increase rate on the outer surface outstripped the temperature increase rate on the inner surface of the bone, thus leading to a significant temperature difference. Further, there was a slowdown in the rate of temperature increase, which led to a gradual convergence of the temperature values inside and outside the bone, followed by temperature stabilization at a stable level (plateau), which was different for the studied areas. During this period, the temperature difference was 3.5–6 °C and it remained at this level until the end of the study. At a constant heating mode (60/70/80 °C), temperature stabilization occurred at the level of 55/61/70 °C in the center of the medullary canal and at the level of 58/67/75 °C under the heater, respectively. The period before reaching the stabilization temperature was 30–40 min. The stable temperature levels both inside and outside the bone were below the temperature stabilization level of the heater. Therefore, to achieve the planned temperature in the center of the bone to its outer surface, it is necessary to apply a high temperature, i.e., a downward temperature gradient is formed: the heater stabilization temperature – the temperature on the outer surface – the temperature inside the medullary canal. Increasing the exposure temperature can shorten the heating period, but increase the temperature difference during the heating period (up to 25 °C in the fifth minute of heating when using the maximum heating mode).Conclusion. To ensure reaching the required temperature (60°C) within a short time (15–20 min) while maintaining optimal temperature parameters, it was proposed to develop variable temperature modes that would combine the initial use of the maximum heating mode until reaching the desired temperature in medullary cavity, followed by switching to a constant temperature mode, which allowed maintaining the achieved temperature level during therapeutic exposure.
Ace gene insertion/deletion polymorphism is associated with glioblastoma in an Iranian population: a case-control study
Authors: Moqadami A. , Agah E. M. , Khalaj-Kondori M. 
Published: May 2023

Background. The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been reported to be associated with the pathogenesis and development of human cancers.This study aimed to assess the potential association between ACE (I/D) polymorphism and glioblastoma in an Iranian population.Material and Methods. This case-control study was conducted on 80 patients with glioblastoma and 80 healthy blood donors as controls. Gap-polymerase chain reaction (Gap-PCR) was used to determine the ACE (I/D) genotypes. PCR products were separated and measured by electrophoresis on a 2 % agarose gel.Results. Analysis of demographic data showed a significant difference in the family history of cancer between the case and control groups (p=0.03). The distribution of ACE gene variants including II, ID, and DD genotypes was also calculated, and significant differences were seen in the DD genotype (p=0.03) and D allele (p=0.04) between the glioblastoma cases and controls.Conclusion. ACE gene polymorphism was associated with glioblastoma in the study population. Further studies are needed to approve this finding.
Quantitative evaluation of the influence of rainfall changes and groundwater exploitation on the groundwater level: a case study of the northern Huangqihai Basin, China
Authors: Jin Jing , Wang Zihe , Zhao Yiping , Zhu Zhijun , Zhang Jing 
Published: May 2023

Abstract
Based on the hydrogeological perspective, the variation in the groundwater level (W) was selected as the analysis factor, and the rainfall changes and groundwater exploitation (QGE) were considered to be the influencing factors. The influence of the two factors on W in the northern Huangqihai Basin was analyzed qualitatively and quantitatively. Results showed that both rainfall and QGE showed increasing trends from 1996 to 2020, while the W values decreased. The correlation between QGE and W was weaker in wet years than in normal years but was the highest in dry years. The mutation time was determined to be 2004. Based on the slope-changing ratio of the cumulative quantity method and the elastic coefficient method, it was determined that the contribution of rainfall changes to W was 22.08% and that of QGE was 77.92%. This study highlights the effectiveness of the integration of qualitative analyses and quantitative evaluation for identifying the influence of external factors on groundwater and well documents that the elastic coefficient method can be used in this field. More attention should be focused on the scientific management of QGE to minimize its negative influence on the sustainable development of groundwater.
The Function of Autophagy in the Initiation, and Development of
Breast Cancer
Authors: Beilankouhi Elmira Aboutalebi Vand , Valilo Mohammad , Dastmalchi Narges , Teimourian Shahram , Safaralizadeh Reza 
Published: May 2023

Abstract:
Autophagy is a significant catabolic procedure that increases in stressful conditions.
This mechanism is mostly triggered after damage to the organelles, the presence of
unnatural proteins, and nutrient recycling in reaction to these stresses. One of the key
points in this article is that cleaning and preserving damaged organelles and accumulated
molecules through autophagy in normal cells helps prevent cancer. Since dysfunction of
autophagy is associated with various diseases, including cancer, it has a dual function in
tumor suppression and expansion. It has newly become clear that the regulation of autophagy
can be used for the treatment of breast cancer, which has a promising effect of increasing
the efficiency of anticancer treatment in a tissue- and cell-type-specific manner
by affecting the fundamental molecular mechanisms. Regulation of autophagy and its
function in tumorigenesis is a vital part of modern anticancer techniques. This study discusses
the current advances related to the mechanisms that describe essential modulators
of autophagy involved in the metastasis of cancers and the development of new breast
cancer treatments.