bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: Thyroid carcinoma invading trachea: Multidisciplinary resection and reconstruction assisted by extracorporeal membrane oxygenation
Authors: He Bo , Zhang Shixin , Ren Lin , Zhou Yi , Chen Qiao , Tang Jinghua , Zhang Yi , Tang Meng , Qiu Yang , Wang Haidong 
Published: January 2023

BackgroundWhen thyroid cancer invades the trachea, tumor resection and trachea reconstruction are required. Although the traditional way of anesthesia and tracheal intubation can maintain the necessary ventilation function during the operation, tracheal intubation affects the surgical field of vision and is not conducive to the protection of the recurrent laryngeal nerve beside the trachea during the operation.Case presentationExtracorporeal membrane oxygenation (ECMO) is used to replace traditional tracheal intubation in the process of resection and end-to-end anastomosis of tracheal tumors, and complete tracheal tumor resection and trachea reconstruction are achieved.ConclusionUsing ECMO for thyroid carcinoma resection, invaded trachea resection, and trachea reconstruction is safe and effective, which reduces the obstruction of endotracheal intubation on the operative field, guarantees the rapid and efficient end-to-end anastomosis in the upper trachea, and clearly avoids laryngeal recurrent nerve injury in the process of anastomosis.
Outcomes of the advanced visualization in corneal surgery evaluation trial; a non-inferiority randomized control trial to evaluate the use of intraoperative OCT during Descemet membrane endothelial keratoplasty
Authors: Muijzer Marc B. , Delbeke Heleen , Dickman Mor M. , Nuijts Rudy M.M.A. , Noordmans Herke Jan , Imhof Saskia M. , Wisse Robert P. L. 
Published: January 2023

ObjectiveTo evaluate if an intraoperative-OCT (iOCT) optimized surgical protocol without prolonged overpressure is non-inferior to a standard protocol during Descemet membrane endothelial keratoplasty (DMEK).MethodsSixty-five pseudophakic eyes of 65 patients with Fuchs endothelial dystrophy scheduled for routine DMEK were recruited in this prospective non-inferiority international multicenter randomized control trial. Subjects were randomized to the control arm (n=33) without iOCT-use and raising the intraocular pressure above normal physiological limits for 8 minutes (i.e., overpressure) or the intervention arm (n=32) with OCT-guidance to assess graft orientation and adherence, while refraining from prolonged overpressure. The primary outcome was the incidence of postoperative surgery-related adverse events (AE). The non-inferiority margin was set at a risk difference of 10%. Secondary outcomes included iOCT-aided surgical decision making, surgical times, and endothelial cell density (ECD) corrected distance visual acuity (CDVA) at 6 months follow-up.ResultsIn the intervention group, 12 subjects developed 13 AEs compared to 13 AEs in 10 subjects in the control group (P=0.644). The risk difference measured -0.32% (95%CI: -10.29 – 9.84). The ECD and CDVA did not differ between the two groups 3 and 6 months postoperatively (P=&gt;0.05). Surgeons reported that iOCT aided surgical decision-making in 40% of cases. Surgery and graft unfolding time were, respectively, 13% and 27% shorter in the iOCT-group.ConclusionsiOCT-guided DMEK surgery with refraining from prolonged over-pressuring was non-inferior compared to conventional treatment. Surgery times were reduced considerably and iOCT aided surgical decision-making in 40% of cases. Refraining from prolonged overpressure did not affect postoperative ECD or CDVA.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03763721 (NCT03763721).
Invertebrates and herptiles for livelihoods—ethnozoological use among different ethnic communities in Jammu and Kashmir (Indian Himalayas)
Authors: Hassan Musheerul , Haq Shiekh Marifatul , Amjad Muhammad Shoaib , Ahmad Riyaz , Bussmann Rainer W. , Pérez de la Lastra José Manuel 
Published: January 2023

Background: Ethnic communities have relied on animals and their derived products for ages, and their use is often intricately related to many cultural features. In remote regions across the globe, indigenous peoples have been using invertebrates and herptiles for a variety of purposes (medicine, food, culture, and spiritual importance); however, related scientific research is sparse, particularly in the western Himalayas. In this respect, we collected useful information on invertebrates and herpetofauna from Jammu and Kashmir, India, across different ethnic groups, i.e., Gujjar, Bakarwal, Dogra, Kashmiri, and Pahari.Methodology: The data were gathered using semi-structured interviews followed by group discussions. The information gathered was analyzed using ordination techniques (principal component analysis). The Venn diagram was used to investigate cross-cultural similarities and differences between ethnic groups.Results: We documented 30 species belonging to five classes and 20 families used for different ethnozoological practices (medicinal, magico-religious, food, costume, omen, poultry, and agricultural purposes). The use of fauna resources varied across ethnic groups, and cross-cultural examination revealed that Kashmiri and Pahari populations were more similar in their species utilization. The maximum number of species (27%) was uniquely used by Kashmiri, followed by Pahari (17%), and the least by Dogra and Gujjar (3% each). The ethnozoological use of all documented species is unprecedented. In addition to ethnozoological usage, various documented species (Apis cerana, Apis mellifera, Hirudinaria granulosa, and Bombyx mori) were also important for the local population’s livelihoods.Conclusion: Our findings can be considered the baseline for understanding the relationship of invertebrates and herptiles with specific ethnic groups and will aid in the development of future research projects that can assess the interaction between local fauna and the diverse ethnic groups.
AGREE II for TCM: Tailored to evaluate methodological quality of TCM clinical practice guidelines
Authors: Xie Xiuli , Wang Yangyang , Li Hui 
Published: January 2023

Background: The Appraisal of Guidelines Research and Evaluation (AGREE) II instrument has been widely used in the methodological quality assessment of clinical practice guidelines (CPG). Chinese medicine CPGs have unique characteristics which distinguish them from those of Western medicine, e.g. syndrome differentiation, on which treatments are based. As such, certain domains and items in AGREE II are unsuitable for assessing TCM CPGs. Therefore, it is necessary to adjust and supplement the description and rating section of some items of the AGREE Ⅱinstrument.Purpose: To adjust and expand AGREE II according to characteristics of TCM clinical practice guidelines.Methods: A research working group was established, consisting of a core working group and an expert consensus group, before a systematic literature search performed to screen for TCM guidelines. Two researchers evaluated the quality of the included guidelines using AGREE Ⅱ and later proposed adjustments to some items of AGREE Ⅱ and supplementary comments, which were applicable to TCM CPGs, and drafted an initial version of AGREE Ⅱ for TCM. Suggestions from literature on development and evaluation of TCM CPGs were solicited and integrated into the revised version, which 16 experts were then invited to advise on. When the experts reached a consensus, their comments to the draft were adopted by the core group into the final version.Results: After evaluating the included TCM guidelines, the two researchers offered adjustments and supplementary comments for AGREE Ⅱ Items 1, 7, 10, 11, 12, 15, and 18, and drafted an initial version of AGREE Ⅱ for TCM. Combining suggestions from the literature on development and quality evaluation of TCM clinical guidelines, the core working group modified AGREE Ⅱ items 2, 4, 5, 8, 9, 13, 20, and 21, then proposed the revised version of AGREE Ⅱ for TCM, on which was advised by a group of experts, before consensus on improvements was reached. The results of the first round of expert surveys showed strong agreement, and experts’ opinions were adopted into the final version of AGREE Ⅱ for TCM.Conclusion: Based on the characteristics of the TCM CPGs, we adjustment and expansion were made to create AGREE II for TCM. This version is suitable for the assessment of methodological quality of TCM CPGs, capable of providing content support for the standardization of procedures and methods of formulating TCM CPGs.
Experimental analysis of the performance of a new shipboard gravity gradient measurement system
Authors: Li Rui , Li Da , Shu Qing , Fan Zhenyu , Lu Kai , Zhou Jianxin , Zhang Jiahong , Xu Guangjing 
Published: January 2023

The gravity gradient tensor, which has a higher resolution than gravity, is used in a variety of fields, including the discovery of energy resources, auxiliary navigation, and national defense building. Our team has achieved significant advancements in various essential technologies, such as high-resolution accelerometers, and has constructed China’s first self-controllable shipboard gravity gradient measurement system. In the laboratory, accuracy is determined using the mass gravitation technique, static test accuracy of Tuv and Txy is 7.22 E and 3.58 E, while dynamic test accuracy of Tuv and Txy is 9.09 E and 4.16 E. For outfield shipborne test measurement, the internal accord accuracy of Tuv and Txy of the repeat line is 28.2E@750m and 28.8E@750m, and that of the intersection point is 28.2E@750m and 26.8E@750m. The performance of the system is completely validated by dynamic and static testing, laying the groundwork for the practical implementation of gravity gradient technology.
Melatonin integrates multidimensional regulation of Na+/K+-ATPase in ionocytes and promotes stress and ease response in hypoxia-induced air-breathing fish: lessons from integrative approach
Authors: Peter M. C. Subhash , Gayathry R. , Simi S. , Peter Valsa S. 
Published: January 2023

As circadian regulator, melatonin is involved in many physiological processes including ionosmotic regulation in fishes. Na+/K+-ATPase (NKA), an ubiquitous Na+/K+ transporter in ionocyte epithelia that drives electrochemical Na+ gradients and systemic osmotic integration, is a target of stress in fish. However, it is not certain how melatonin regulates NKA functions in ionocyte epithelia and how it modulates the adaptive response such as stress and ease response in fish particularly in hypoxia condition. We, thus, examined the short-term in vivo action of melatonin on the dynamics of NKA regulation in branchial, renal and intestinal ionocytes of hypoxia-induced air-breathing fish (Anabas testudineus Bloch). Interestingly, we found a rise in plasma melatonin in fish when kept for 30 min of forced submergence in water and that indicates a role for melatonin in hypoxia tolerance. A fall in blood [Na+, K+] occurred in these hypoxic fish which later showed a recovery after melatonin treatment. Similarly, melatonin favored the fall in NKA activity in branchial and renal epithelia of hypoxic fish, though it remarkably stimulated its activities in non-stressed fish. Likewise, melatonin that produced differential pattern of mRNA expression in nkaα1-subunit isoforms (nkaα1a, nkaα1b and nkaα1c) and melatonin receptor isoforms (mtnr1a, mtnr1bb, mtnr1bbx1x2) in the tested ionocyte epithelia, showed reversed expression in hypoxic fish. In addition, the rise in NKAα-protein abundance in branchial and renal epithelia of melatonin-treated hypoxic fish indicated a recovery action of melatonin. A higher NKAα-immunoreactivity was found in the immunohistochemical and immunofluorescent images of branchial ionocytes and renal proximal and distal ionocytes of hypoxic fish treated with melatonin. Furthermore, an activation of PKA and PKG-dependent phosphorylation was found in branchial epithelia of hypoxic fish. The generated integrative parabola model showed that melatonin has a maximum targeted action on NKA function in the renal epithelia, suggesting its lead role in the integration of ionosmotic balance during the recovery or ease response. Over all, the data indicate a multidimensional and preferential action of melatonin on NKA regulation in fish ionocytes that integrate the recovery action against hypoxia, thus pointing to a major role for melatonin in stress and ease response in this fish.
Relative age effects in track-and-field: Identification and performance rebalancing
Authors: Difernand Audrey , De Larochelambert Quentin , Homo Sébastien , Rousseau Florian , Antero Juliana , Toussaint Jean-François , Sedeaud Adrien 
Published: January 2023

Introduction:Relative Age Effect (RAE) consists of a biased distribution of the dates of birth in a same-age group.Objectives:This study aimed to investigate Relative Age Effect among French athletes in different track-and-field events, and propose a corrective adjustment method to highlight the true potential of an athlete with respect to his/her relative age.Methods:358,610 performances from 2009 to 2019 of female and male athletes between 12 and 21 years old were collected. Relative age distributions of performances were analyzed by level of competitiveness (“All,” “Top50%,” “Top10%” where “all” represents all athletes, top50% and top10% represent the best 50% and 10% of athletes per age category respectively) and age category, with chi-square and odd-ratio statistics. A linear relationship between distribution of performances and age leads to a calibration coefficient allowing to rebalance the performance by considering the effect of Relative Age Effect. Validation is obtained by Wilcoxon statistical test on actual athlete data.Results:Relative Age Effect is present in all types of events. It is larger when the level of competitiveness increases. In male 100 m sprint, 1 year difference between two athletes birth date represents an average gain of 931.01 ms (6.5%) in the U13 (Under 13 years old) and 229.65 ms (1.9%) in the U17 (Under 17 years old) categories. Our validated rebalancing methods allows to compensate for the biases induced by the relative age effect. By comparing the rebalanced performance and the realised performance of each athlete, we cannot say that they are significantly different. On average, there is no significant difference between these two performances.Conclusion:This study showed that there is a relative age effect among young French athletes, with an even greater effect as the level of competition increases. Thanks to the rebalancing method that has been validated, performances can now be better appreciated according to category and event.
Study on factors influencing college students’ digital academic reading behavior
Authors: Chang Liyan , Wang Yujie , Liu Jing , Feng Yao , Zhang Xinyao 
Published: January 2023

BackgroundAffected by the COVID-19, many colleges have adopted online teaching. Meanwhile, the digital transformation of academic journals has shifted readers’ reading habits from traditional paper media to digital media. Digital academic reading has become the main reading method of college students during the COVID-19 pandemic.PurposeThe purpose of this study was to investigate the behavioral characteristics of college students’ digital academic reading and explore the internal factors and external environmental factors affecting the Intention and Use behavior of digital academic reading. At the same time this study provide recommendations to address these influencing factors in terms of the individual, the environment and library resources.MethodsBased on UTAUT2 model and digital academic reading theories, this paper constructs a digital academic reading information behavior (DARB) model of college students to examine college students’ digital academic reading behavior and intention. College students with digital academic reading behavior were recruited as research participants. A multi-stage sampling technique was used to collect representative samples from universities in Nanjing. 239 respondents participated in the questionnaire, with 189 providing valid data. Results: Effort expectancy (EE), social influence (SI), price value (PV), perceived risk (PR) and habit (BH) have a significant impact on behavioral intention (BI), and behavioral intention (BI) and habit (BH) have a significant impact on use behavior (B). However, performance expectancy (PE) and facilitating conditions (FC) have no significant influence on behavioral intention (BI).Originality/valueThe findings of this study will help fill the gap in previous research on the relationship between the influencing factors of digital academic reading and college students’ reading intentions and behaviors, so as to provide a basis for improving the academic reading literacy program in colleges and optimizing the current digital academic reading environment.
Improving hardiness among university students: A meta-analysis of intervention studies
Authors: Jianping Gao , Zhihui Zhu , Roslan Samsilah , Zaremohzzabieh Zeinab , Burhanuddin Nur Aimi Nasuha , Geok Soh Kim 
Published: January 2023

IntroductionIncreasing the hardiness of students is a crucial objective in higher education. Universities and colleges have created a variety of interventions to improve students' overall hardiness.MethodsIn terms of the effects of such interventions, empirical research has shown inconclusive results. This meta-analysis applies 12 effect sizes from 12 independent empirical studies, with a total of 640 participants, to assess the overall impact of interventions on students' hardiness and to test for moderators, in light of the contradictory findings in prior work. The current meta-analysis calculates the standardized mean differences (SMD) of pre-post interventions. The level of study heterogeneity, represented by I2, was interpreted as small (I2 ≤ 25%), moderate (25% &lt; I2 ≤ 50%), substantial (50% &lt; I2 ≤ 75%), or considerable (I2 &gt; 75%). Twelve studies met the inclusion criteria and were included in the meta-analysis.ResultsThe results show that the interventions had a significant positive overall effect on students' hardiness (g = 0.998, k = 12) and show significant heterogeneity among effect sizes. Among the interventions, cognitive-based intervention yielded the largest mean effect size (g = 2.015, k = 5). Furthermore, moderator analyses suggest that the effects of the interventions on students' hardiness are moderated by respondent type, culture, intervention type, research design, years, and duration of intervention.DiscussionWe conclude that interventions that promote students' hardiness are officious. Despite the low homogeneity of the results and limitations of this meta-analysis (e.g., a small number of included studies) which might have influenced the findings, the large fail-safe N suggests that these findings are robust. The study examined potential causes of heterogeneity and emphasized the importance of further research in this area.
Association between night shift work and methylation of a subset of immune-related genes
Authors: Ferrari Luca , Monti Paola , Favero Chiara , Carugno Michele , Tarantini Letizia , Maggioni Cristina , Bonzini Matteo , Pesatori Angela Cecilia , Bollati Valentina 
Published: January 2023

IntroductionNight shift (NS) work has been associated with an increased risk of different conditions characterized by altered inflammatory and immune responses, such as cardio-metabolic and infectious diseases, cancer, and obesity. Epigenetic modifications, such as DNA methylation, might mirror alterations in biological processes that are influenced by NS work.MethodsThe present study was conducted on 94 healthy female workers with different working schedules and aimed at identifying whether NS was associated with plasmatic concentrations of the inflammatory proteins NLRP3 and TNF-alpha, as well as with DNA methylation levels of ten human endogenous retroviral (HERV) sequences, and nine genes selected for their role in immune and inflammatory processes. We also explored the possible role of the body mass index (BMI) as an additional susceptibility factor that might influence the effects of NS work on the tested epigenetic modifications.Results and discussionWe observed a positive association between NS and NLRP3 levels (p-value 0.0379). Moreover, NS workers retained different methylation levels for ERVFRD-1 (p-value = 0.0274), HERV-L (p-value = 0.0377), and HERV-P (p-value = 0.0140) elements, and for BIRC2 (p-value = 0.0460), FLRT3 (p-value = 0.0422), MIG6 (p-value = 0.0085), and SIRT1 (p-value = 0.0497) genes. We also observed that the BMI modified the relationship between NS and the methylation of ERVE, HERV-L, and ERVW-1 elements. Overall, our results suggest that HERV methylation could pose as a promising biomolecular sensor to monitor not only the effect of NS work but also the cumulative effect of multiple stressors.
Determinants of social distancing adherence
Authors: Gerretsen Philip , Kim Julia , Brown Eric E. , Quilty Lena C. , Wells Samantha , Caravaggio Fernando , Song Jianmeng , Sanches Marcos , Agic Branka , Pollock Bruce G. , Graff-Guerrero Ariel 
Published: January 2023

IntroductionGovernments and public health authorities across many jurisdictions implemented social (physical) distancing measures to contain the spread of the 2019 novel coronavirus disease (COVID-19). Adherence to these measures is variable and likely influenced by various factors. This study aimed to 1) identify the individual sociodemographic, COVID-19 and social distancing related, and psychological determinants of social distancing adherence, and 2) explore regional differences in social distancing adherence in the United States (U.S.) and English-speaking Canada based on each region's discrepant response to social distancing restrictions.MethodsA web-based repeated cross-sectional survey was conducted in 4,942 English-speaking participants from the four most populous U.S. states, specifically New York, California, Texas, and Florida, and Canada (www.covid19-database.com). The study was conducted at two timepoints, from May 1 to 5, 2020 (n = 1,019, Canadian participants only) and from July 6 to 10, 2020 (n = 3,923). Separate univariate models were computed for individual sociodemographic, COVID-19 and social distancing related, and psychological determinants of social distancing adherence. To determine the total variance explained, a univariate analysis including all of the determinants was performed. Regional differences in social distancing were compared between the four U.S. states and Canada, and between the U.S. as a whole and Canada.ResultsAdherence to social distancing was higher in May (mean = 4.4/5.0±0.7) compared to July (mean = 4.3/5.0±0.7) [t(4940) = 6.96, p &lt; 0.001], likely a reflection of relaxing restrictions. There were no regional differences in adherence. Sociodemographic, COVID-19 and social distancing related, and psychological determinants explained 10, 36, and 23% of the variance of social distancing adherence, respectively. Higher perceived seriousness of COVID-19 [β (SE) = 0.39 (0.01), p &lt; 0.001, partial η2 = 0.22], lower risk propensity [β (SE) = −0.15 (0.01), p &lt; 0.001, partial η2 = 0.06], germ aversion [β (SE) = 0.12 (0.01), p &lt; 0.001, partial η2 = 0.03], age [β (SE) = 0.01 (0.00), p &lt; 0.001, partial η2 = 0.02], and greater social support [β (SE) = 0.03 (0.00), p &lt; 0.001, partial η2 = 0.02] had the largest effects on social distancing adherence.ConclusionPublic service initiatives to emphasize the serious consequences of infection and targeted interventions toward certain sociodemographic groups, such as younger adults and vulnerable individuals in greater need of social support, may help enhance the public's adherence to social distancing measures during subsequent waves of COVID-19 and future pandemics.