bluuebunny/crossref_metadata_2025_split huggingface dataset:
The durability of acetylated beech (Fagus sylvatica L.) laminated veneer lumber (LVL) against wood-destroying basidiomycetes
Authors: Slabohm Maik , Brischke Christian , Militz Holger 
Published: May 2023

AbstractThe overall aim of this study was to investigate the durability of acetylated beech (Fagus sylvatica L.) laminated veneer lumber (LVL) against wood-destroying basidiomycetes. The secondary objective was to test whether the specimen size affects the mass loss and durability assessment of wood-material under test. The durability test was based on the pre-standard prEN 113-3. Six materials (acetylated beech LVL, untreated beech LVL, beech solid wood, pine sapwood (Pinus sylvestris L.), larch (Larix decidua Mill.) 3-layer slab, larch solid wood) were tested using three specimen geometry designs (50 × 25 × 15 mm3 as well as 50 × 50 × 19 mm3 with and without sealed edges) against Coniophora puteana, Rhodonia placenta, Gloeophyllum trabeum, Trametes versicolor, and Pleurotus ostreatus. The durability assessment was made using the arithmetic mean and median percentage mass loss (ML), the relative ML (x-values), and the decay susceptibility index (DSI). It was found that mass loss was affected by the test fungus, the material, and the specimen size and design, with the latter being the most essential factor in this study. In addition, the assessment parameter had a significant effect on the durability classification. Furthermore, small differences in ML resulted in different durability classes (DC) in some cases, whereas large differences in ML did not. However, acetylated beech LVL was always considerably durable (DC 1) against all tested fungi independent of the specimen design and durability assessment method.
The system of autono‑mobility: computer vision and urban complexity—reflections on artificial intelligence at urban scale
Authors: Iapaolo Fabio 
Published: May 2023

AbstractFocused on city-scale automation, and using self-driving cars (SDCs) as a case study, this article reflects on the role of AI—and in particular, computer vision systems used for mapping and navigation—as a catalyst for urban transformation. Urban research commonly presents AI and cities as having a one-way cause-and-effect relationship, giving undue weight to AI’s impact on cities and overlooking the role of cities in shaping AI. Working at the intersection of data science and social research, this paper aims to counter this trend by exploring the reverse perspective: how do cities affect the development, and expose the present limits, of SDCs? The contribution of this paper is threefold. First, by comparing urban and nonurban environments and thoroughly examining the relationship between computer vision and city-specific sociality and form, it defines machine autonomy/automation as a function of the sociotechnical milieu in which an AI system operates. Second, and related, the paper problematizes the notion of SDCs as autonomous technologies and the role it plays in envisioning contending policy arrangements and technical solutions for achieving full driving automation. Finally, the article offers insight into a materialist and spatialized understanding of AI—namely, not as an abstract quality susceptible to replication within discrete machines, but rather as a distributed property emerging through embodied interactions among a multiplicity of agents (human, non-human, and technological) within/with their environments.
Diversity of the squid genus Leachia (Oegopsida: Cranchiidae) in the Pacific Ocean
Authors: Evans A. B. , Bolstad K. S. R. 
Published: May 2023

AbstractLeachia is a cosmopolitan tropical/temperate genus of ‘glass’ squids (Cranchiidae) whose taxonomy has been plagued with instability typical of the family. Eight species are currently believed to exist worldwide, including some not yet described. This review assesses the Pacific taxa, describes a novel species, L. separata, and provides updated diagnoses for the other Pacific species. Type material and original descriptions are compared, and brief remarks provided on the Atlantic taxa. The most useful characters for identifying Leachia species appear to be the number of ocular photophores and the configuration of the ventral cartilaginous strips and associated tubercles on the mantle, with arm and sucker-ring dentition also proving useful in some taxa. Further work on the genus is needed, ideally including molecular tools.
Optimization of antimicrobial peptides for the application against biocorrosive bacteria
Authors: Stillger L. , Viau L. , Kamm L. , Holtmann D. , Müller D. 
Published: May 2023

Abstract
Microbiologically influenced corrosion is a common problem in the industrial field due to the deterioration of metals in the presence of various microorganisms, in particular sulfate-reducing bacteria (SRB) and sulfur-oxidizing bacteria (SOB). A common method to reduce microbiologically influenced corrosion is the application of biocides. The limited number of suitable biocides and the resulting development of resistance, high dosage, and high application rate hinder an effective application. An environmentally friendly alternative could be the application of antimicrobial peptides (AMP), which have already been established in the field of medical devices for a while. Here, the successful treatment of different AMPs against 3 SRB and 1 SOB was demonstrated. The peptide L5K5W was favored due to its broad activity, high stability, and simple structure resulting in low synthesis costs. An alanine scan showed that substitution of leucine with tryptophan increased the activity of this peptide twofold compared to the original peptide against D. vulgaris, the main representative of SRB. Additional optimization of this modified peptide through changes in amino acid composition and lipidations significantly increased the effectiveness, finally resulting in a minimum inhibitory concentration (MIC) of 15.63 μg/mL against Desulfovibrio vulgaris. Even against the marine SRB Desulfovibrio indonesiensis with a required salt concentration of min. 2%, an activity of the peptides can be observed (MIC: 31.25 μg/mL). The peptides also remained stable and active for 7 days in the supernatant of the bacterial culture.

Key points
• Antimicrobial peptides provide an alternative to combat biocorrosive bacteria.
• Optimization of the peptide sequence leads to a significant increase in activity.
• The investigated peptides exhibit high stability, both in the medium and in the bacterial supernatant.

Graphical abstract
Tau seeds occur before earliest Alzheimer’s changes and are prevalent across neurodegenerative diseases
Authors: Manca Matteo , Standke Heidi G. , Browne Danielle F. , Huntley Mikayla L. , Thomas Olivia R. , Orrú Christina D. , Hughson Andrew G. , Kim Yongya , Zhang Jing , Tatsuoka Curtis , Zhu Xiongwei , Hiniker Annie , Coughlin David G. , Galasko Douglas , Kraus Allison 
Published: May 2023

AbstractTau neurofibrillary tangles are a hallmark of Alzheimer’s disease neuropathological change. However, it remains largely unclear how distinctive Alzheimer’s disease tau seeds (i.e. 3R/4R) correlate with histological indicators of tau accumulation. Furthermore, AD tau co-pathology is thought to influence features and progression of other neurodegenerative diseases including Lewy body disease; yet measurements of different types of tau seeds in the setting of such diseases is an unmet need. Here, we use tau real-time quaking-induced conversion (RT-QuIC) assays to selectively quantitate 3R/4R tau seeds in the frontal lobe which accumulates histologically identifiable tau pathology at late disease stages of AD neuropathologic change. Seed quantitation across a spectrum of neurodegenerative disease cases and controls indicated tau seeding activity can be detected well before accompanying histopathological indication of tau deposits, and even prior to the earliest evidence of Alzheimer’s-related tau accumulation anywhere in the brain. In later stages of AD, 3R/4R tau RT-QuIC measures correlated with immunohistochemical tau burden. In addition, Alzheimer’s tau seeds occur in the vast majority of cases evaluated here inclusive of primary synucleinopathies, frontotemporal lobar degeneration and even controls albeit at multi-log lower levels than Alzheimer’s cases. α-synuclein seeding activity confirmed synucleinopathy cases and further indicated the co-occurrence of α-synuclein seeds in some Alzheimer’s disease and primary tauopathy cases. Our analysis indicates that 3R/4R tau seeds in the mid-frontal lobe correlate with the overall Braak stage and Alzheimer’s disease neuropathologic change, supporting the quantitative predictive value of tau RT-QuIC assays. Our data also indicate 3R/4R tau seeds are elevated in females compared to males at high (≥ IV) Braak stages. This study suggests 3R/4R tau seeds are widespread even prior to the earliest stages of Alzheimer’s disease changes, including in normal, and even young individuals, with prevalence across multiple neurodegenerative diseases to further define disease subtypes.
A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaques
Authors: Bayazid Rabeah , Orru’ Christina , Aslam Rabail , Cohen Yvonne , Silva-Rohwer Amelia , Lee Seong-Ki , Occhipinti Rossana , Kong Qingzhong , Shetty Shashirekha , Cohen Mark L. , Caughey Byron , Schonberger Lawrence B. , Appleby Brian S. , Cali Ignazio 
Published: May 2023

AbstractThe presence of amyloid kuru plaques is a pathological hallmark of sporadic Creutzfeldt–Jakob disease (sCJD) of the MV2K subtype. Recently, PrP plaques (p) have been described in the white matter of a small group of CJD (p-CJD) cases with the 129MM genotype and carrying resPrPD type 1 (T1). Despite the different histopathological phenotype, the gel mobility and molecular features of p-CJD resPrPD T1 mimic those of sCJDMM1, the most common human prion disease. Here, we describe the clinical features, histopathology, and molecular properties of two distinct PrP plaque phenotypes affecting the gray matter (pGM) or the white matter (pWM) of sCJD cases with the PrP 129MM genotype (sCJDMM). Prevalence of pGM- and pWM-CJD proved comparable and was estimated to be ~ 0.6% among sporadic prion diseases and ~ 1.1% among the sCJDMM group. Mean age at onset (61 and 68 years) and disease duration (~ 7 months) of pWM- and pGM-CJD did not differ significantly. PrP plaques were mostly confined to the cerebellar cortex in pGM-CJD, but were ubiquitous in pWM-CJD. Typing of resPrPD T1 showed an unglycosylated fragment of ~ 20 kDa (T120) in pGM-CJD and sCJDMM1 patients, while a doublet of ~ 21–20 kDa (T121−20) was a molecular signature of pWM-CJD in subcortical regions. In addition, conformational characteristics of pWM-CJD resPrPD T1 differed from those of pGM-CJD and sCJDMM1. Inoculation of pWM-CJD and sCJDMM1 brain extracts to transgenic mice expressing human PrP reproduced the histotype with PrP plaques only in mice challenged with pWM-CJD. Furthermore, T120 of pWM-CJD, but not T121, was propagated in mice. These data suggest that T121 and T120 of pWM-CJD, and T120 of sCJDMM1 are distinct prion strains. Further studies are required to shed light on the etiology of p-CJD cases, particularly those of T120 of the novel pGM-CJD subtype.
Referral rate and false-positive rates in a hearing screening program among high-risk newborns
Authors: Thangavelu Kruthika , Martakis Kyriakos , Feldmann Silke , Roth Bernhard , Lang-Roth Ruth 
Published: May 2023

Abstract
Aim
More studies exploring referral rates and false-positive rates are needed to make hearing screening programs in newborns better and cost-effective. Our aim was to study the referral and false-positivity rates among high-risk newborns in our hearing screening program and to analyze the factors potentially associated with false-positive hearing screening test results.

Methods
A retrospective cohort study was done among the newborns hospitalized at a university hospital from January 2009 to December 2014 that underwent hearing screening with a two-staged AABR screening protocol. Referral rates and false-positivity rates were calculated and possible risk factors for false-positivity were analyzed.

Results
4512 newborns were screened for hearing loss in the neonatology department. The referral rate for the two-staged AABR-only screening was 3.8% with false-positivity being 2.9%. Our study showed that the higher the birthweight or gestational age of the newborn, the lower the odds of the hearing screening results being false-positive, and the higher the chronological age of the infant at the time of screening, the higher the odds of the results being false-positive. Our study did not show a clear association between the mode of delivery or gender and false-positivity.

Conclusion
Among high-risk infants, prematurity and low-birthweight increased the rate of false-positivity in the hearing screening, and the chronological age at the time of the test seems to be significantly associated with false-positivity.
Associations of longitudinal height and weight with clinical outcomes in pediatric kidney replacement therapy: results from the ESPN/ERA Registry
Authors: Bonthuis Marjolein , Bakkaloglu Sevcan A. , Vidal Enrico , Baiko Sergey , Braddon Fiona , Errichiello Carmela , Francisco Telma , Haffner Dieter , Lahoche Annie , Leszczyńska Beata , Masalkiene Jurate , Stojanovic Jelena , Molchanova Maria S. , Reusz George , Barba Adela Rodriguez , Rosales Alejandra , Tegeltija Sanja , Ylinen Elisa , Zlatanova Galia , Harambat Jérôme , Jager Kitty J. 
Published: May 2023

Abstract

Background
Associations between anthropometric measures and patient outcomes in children are inconsistent and mainly based on data at kidney replacement therapy (KRT) initiation. We studied associations of height and body mass index (BMI) with access to kidney transplantation, graft failure, and death during childhood KRT.

Methods
We included patients < 20 years starting KRT in 33 European countries from 1995–2019 with height and weight data recorded to the ESPN/ERA Registry. We defined short stature as height standard deviation scores (SDS) < –1.88 and tall stature as height SDS > 1.88. Underweight, overweight and obesity were calculated using age and sex-specific BMI for height-age criteria. Associations with outcomes were assessed using multivariable Cox models with time-dependent covariates.

Results
We included 11,873 patients. Likelihood of transplantation was lower for short (aHR: 0.82, 95% CI: 0.78–0.86), tall (aHR: 0.65, 95% CI: 0.56–0.75), and underweight patients (aHR: 0.79, 95%CI: 0.71–0.87). Compared with normal height, patients with short and tall statures showed higher graft failure risk. All-cause mortality risk was higher in short (aHR: 2.30, 95% CI: 1.92–2.74), but not in tall stature. Underweight (aHR: 1.76, 95% CI: 1.38–2.23) and obese (aHR: 1.49, 95% CI: 1.11–1.99) patients showed higher all-cause mortality risk than normal weight subjects.

Conclusions
Short and tall stature and being underweight were associated with a lower likelihood of receiving a kidney allograft. Mortality risk was higher among pediatric KRT patients with a short stature or those being underweight or obese. Our results highlight the need for careful nutritional management and multidisciplinary approach for these patients.

Graphical abstract
Understanding the patient and family experience of nutrition and dietetic support during childhood cancer treatment
Authors: Clarke Emma , Pugh Gemma , van den Heuvel Eveline , Winstanley Mark , Wood Andrew C. , Laughton Stephen J. , Lovell Amy L. 
Published: May 2023

Abstract
Purpose
This study aimed to understand the experience of families caring for a child with cancer in New Zealand (NZ) who received nutrition and dietetic support during cancer treatment and their preferences for the delivery, format, and timing of nutrition information.

Methods
Childhood cancer patients and their families (N = 21) participated in a mixed-methods study at a specialist paediatric oncology centre in Auckland, NZ. Before the semi-structured interview, participants completed a questionnaire capturing demographic, disease, and treatment characteristics of their child, their nutrition concerns, and their information needs. Quantitative data were described, and qualitative thematic analysis of the semi-structured interviews was performed using NVivo data analysis software.

Results
Eighty-six percent of participants indicated they had concerns about their child’s nutrition during treatment. The most common concerns were anorexia, vomiting, and weight loss. While many were happy with the quality of the nutrition support received, one-third of the patients wanted more support. Four key themes emerged from the interviews: (1) patients experience significant and distressing nutrition challenges; (2) patients and families have mixed perceptions of EN; (3) there are gaps in the current nutrition support system for inpatients; and (4) a desire for more accessible nutrition support.

Conclusion
Childhood cancer patients and families experience significant and distressing nutrition challenges during treatment. Standardising information given to patients and their families may optimise nutrition support for paediatric oncology patients and reduce the discordance between families and health professionals. Future implementation of a nutrition decision aid in this population is warranted.
Versorgungswirksamkeit von Psychotherapie aus Patient:innensicht
Authors: Löffler-Stastka Henriette , Hassemer Simeon , Krajic Karl 
Published: May 2023

ZusammenfassungZum Thema der Versorgung mit Psychotherapie sind Informationen über das Ausmaß des Behandlungsbedarfs und des Behandlungserhalts wesentlich. Da oft nur ein Teil der psychisch Kranken die entsprechenden Behandlungen erhält, wurde die Sicht der Betroffenen zum Thema der psychotherapeutischen Versorgung erhoben. Deutlich wurde eine fehlende Transparenz, der aus Behandler:innensicht mit einer adäquaten, patient:innenzentrierten Information und Aufklärung in der tragfähigen Arbeitsbeziehung gegengesteuert werden sollte.
Structural transitions in jammed asymmetric bidisperse granular packings
Authors: Petit Juan C. , Sperl Matthias 
Published: May 2023

AbstractWe study the local structural changes along the jamming transitions in asymmetric bidisperse granular packings. The local structure of the packing is assessed by the contact orientational order, $$\tilde{Q}_{\ell }$$

Q
~

ℓ

, that quantifies the contribution of each contact configuration (Large–Large, Small–Small, Large–Small, Small–Large) in the jammed structure. The partial values of $$\tilde{Q}_{\ell }$$

Q
~

ℓ

are calculated with respect to known ordered lattices that are fixed by the size ratio, $$\delta $$
δ
, of the particles. We find that the packing undergoes a structural transition at $$\phi _J$$

ϕ
J

, manifested by a sudden jump in the partial $$\tilde{Q}_{\ell }$$

Q
~

ℓ

. Each contact configuration contributes to the jammed structure in a different way, changing with $$\delta $$
δ
and concentration of small particles, $$X_{\textrm{S}}$$

X
S

. The results show not only that the packing undergoes a structural change upon jamming, but also that bidisperse packings exhibit local HCP and FCC structures also found in monodisperse packings. This suggests that the jammed structure of bidisperse systems is inherently endowed with local structural order. These results are relevant in understanding how the arrangement of particles determines the strength of bidisperse granular packings.
Graphic abstract
Submarine Groundwater Discharge-Derived Nutrient Fluxes in Eckernförde Bay (Western Baltic Sea)
Authors: Kreuzburg M. , Scholten J. , Hsu Feng-Hsin , Liebetrau V. , Sültenfuß J. , Rapaglia J. , Schlüter M. 
Published: May 2023

AbstractExcess nutrient supply by the rivers and the atmosphere are considered as the major causes for the persistently poor ecological status of the Baltic Sea. More than 97% of the Baltic Sea still suffers from eutrophication due to past and present inputs of nitrogen and phosphorus. One of the poorly quantified nutrient sources in the Baltic Sea is submarine groundwater discharge (SGD). Through seepage meter deployments and a radium mass balance model, a widespread occurrence of SGD along the coastline of Eckernförde Bay was detected. Mean SGD was 21.6 cm d−1 with a calculated freshwater fraction of 17%. Where SGD was detected, pore water sampled by a piezometer revealed a wide range of dissolved inorganic nitrogen (DIN: 0.05–1.722 µmol L−1) and phosphate (PO43−: 0.03–70.5 µmol L−1) concentrations. Mean DIN and PO43− concentrations in non-saline (salinity < 1) pore waters were 59 ± 68 µmol L−1 and 1.2 ± 1.9 µmol L−1, respectively; whereas pore water with salinities > 1 revealed higher values, 113 ± 207 µmol L−1 and 6 ± 12 µmol L−1 for DIN and PO43−, respectively. The nutrient concentrations along the salinity gradient do not suggest that land-derived groundwater is the definitive source of nutrients in the Baltic Sea. Still, SGD may contribute to a major autochthonous nutrient source, resulting from remineralization or dissolution processes of organic matter in the sediments. The DIN and PO43− fluxes derived from SGD rates through seepage meters are 7.9 ± 9.2 mmol m−2 d−1 and 0.5 ± 0.4 mmol m−2 d−1, lower by a factor of ~ 2 and ~ 5 when compared to the fluxes derived with the radium mass balance model (mean DIN: 19 ± 28 mmol m−2 d−1; mean PO43−: 1.5 ± 2.7 mmol m−2 d−1). Assuming that these mean radium-based nutrient fluxes are representative for the coastline of Eckernförde Bay, we arrive at SGD-borne nutrient fluxes of about 1 t km−1 y−1 of nitrogen and 0.2 t km−1 y−1 of phosphorous. These fluxes are lower for DIN and in the same range for phosphorus as compared to the riverine nutrient supply (DIN: 6.3 t km−1 y−1, P: 0.2 km−1 y−1) to the German Baltic Sea identifying SGD-borne nutrients as a secondary nutrient source to the Baltic Sea.
Neurocognitive outcomes in pediatric brain tumors after treatment with proton versus photon radiation: a systematic review and meta-analysis
Authors: Lassaletta Álvaro , Morales Javier S. , Valenzuela Pedro L. , Esteso Borja , Kahalley Lisa S. , Mabbott Donald J. , Unnikrishnan Soumya , Panizo Elena , Calvo Felipe 
Published: May 2023

AbstractBackgroundAdvances in cancer treatments, particularly the development of radiation therapy, have led to improvements in survival outcomes in children with brain tumors. However, radiation therapy is associated with significant long-term neurocognitive morbidity. The present systematic review and meta-analysis aimed to compare the neurocognitive outcomes of children and adolescents with brain tumors treated with photon radiation (XRT) or proton therapy (PBRT).MethodsA systematic search was conducted (PubMed, Embase, Cochrane, and Web of Science from inception until 02/01/2022) for studies comparing the neurocognitive outcomes of children and adolescents with brain tumors treated with XRTvs. PBRT. The pooled mean differences (expressed as Z scores) were calculated using a random effects method for those endpoints analyzed by a minimum of three studies.ResultsTotally 10 studies (n = 630 patients, average age range: 1–20 years) met the inclusion criteria. Patients who had received PBRT achieved significantly higher scores (difference in Z scores ranging from 0.29–0.75, allP < 0.05 and significant in sensitivity analyses) after treatment than those who had received XRT for most analyzed neurocognitive outcomes (i.e., intelligence quotient, verbal comprehension and perceptual reasoning indices, visual motor integration, and verbal memory). No robust significant differences (P > 0.05 in main analyses or sensitivity analyses) were found for nonverbal memory, verbal working memory and working memory index, processing speed index, or focused attention.ConclusionsPediatric brain tumor patients who receive PBRT achieve significantly higher scores on most neurocognitive outcomes than those who receive XRT. Larger studies with long-term follow-ups are needed to confirm these results.