bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interplay between perceived busyness and power distance belief on subjective social status: Consequences for consumer preferences for material versus experiential purchases
Authors: Park Sehoon , Kim Chaeyeong , Park Jane 
Published: August 2023

AbstractThe perception of a busy life as an indicator of self‐worth varies among individuals. Postulating that this perceptual difference can be attributed to one's attitude toward social stratification, the current research examines the interplay between perceived busyness and power distance belief (PDB). We propose that perceived busyness dictates a consumer's subjective social status under low PDB but not under high PDB. Furthermore, the interaction between perceived busyness and PDB determines an individual's relative preference for purchase types: material versus experiential purchases. Study 1 verifies that consumers' perceived busyness has a positive effect on their evaluation of their social status when they have low PDB, whereas this effect disappears when they have high PDB. Study 2 tests the asymmetric effect of perceived busyness and PDB on preference for purchase types, and Study 3 further provides evidence for the mediating role of subjective social status.
Hepatoprotective effect of p‐Coumaric acid against KBrO3‐induced apoptosis in HepG2 cells
Authors: Nivetha Selvaraj , Asha Kumaraswami Radha Thayammal , Srinivasan Subramani , Murali Raju , Kanagalakshmi Ambothi 
Published: August 2023

AbstractIn the present study, we investigated the effect of the p‐Coumaric acid (PCA), a phenolic acid, on potassium bromate (KBrO3) induced oxidative damage, Ras/Raf/MEK signaling, and apoptosis in HepG2 cells. Our findings showed that PCA‐treated cells prevented cytotoxicity compared with KBrO3‐treated cells. Furthermore, KBrO3‐induced oxidative stress and lipid peroxidation was attenuated by PCA and it also increased the antioxidant levels such as SOD, CAT, and GPX. Additionally, PCA inhibited the KBrO3‐induced DNA damage in HepG2 cells. Moreover, PCA treatment suppressed the activation of Ras/Raf/MEK signaling and increased the expression of PRDX‐1. In addition, PCA prevented the KBrO3‐induced apoptosis cascade by altering the expression of proapoptotic, Bax, caspase‐3, and antiapoptotic, Bcl‐2 proteins. The present study proves that PCA inhibited the KBrO3‐induced oxidative stress, DNA damage, and apoptotic signaling cascade in HepG2 cells.
Exploring COVID‐19 education to support vaccine confidence amongst the general adult population with special considerations for healthcare and long‐term care staff: A scoping review
Authors: Murmann Maya , Reed Anna Cooper , Scott Mary , Presseau Justin , Heer Carrie , May Kathryn , Ramzy Amy , Huynh Chau N. , Skidmore Becky , Welch Vivian , Little Julian , Wilson Kumanan , Brouwers Melissa , Hsu Amy T. 
Published: August 2023

AbstractBackgroundDespite the demonstrated efficacy of approved COVID‐19 vaccines, high levels of hesitancy were observed in the first few months of the COVID‐19 vaccines' rollout. Factors contributing to vaccine hesitancy are well‐described in the literature. Among the various strategies for promoting vaccine confidence, educational interventions provide a foundationally and widely implemented set of approaches for supporting individuals in their vaccine decisions. However, the evidence around the measurable impact of various educational strategies to improve vaccine confidence is limited. We conducted a scoping review with the aim of exploring and characterizing educational interventions delivered during the pandemic to support COVID‐19 vaccine confidence in adults.MethodsWe developed a search strategy with a medical information scientist and searched five databases, including Ovid MEDLINE and Web of Science, as well as grey literature. We considered all study designs and reports. Interventions delivered to children or adolescents, interventions on non‐COVID‐19 vaccines, as well as national or mass vaccination campaigns without documented interaction(s) between facilitator(s) and a specific audience were excluded. Articles were independently screened by three reviewers. After screening 4602 titles and abstracts and 174 full‐text articles across two rounds of searches, 22 articles met our inclusion criteria. Ten additional studies were identified through hand searching. Data from included studies were charted and results were described narratively.ResultsWe included 32 studies and synthesized their educational delivery structure, participants (i.e., facilitators and priority audience), and content. Formal, group‐based presentations were the most common type of educational intervention in the included studies (75%). A third of studies (34%) used multiple strategies, with many formal group‐based presentations being coupled with additional individual‐based interventions (29%). Given the novelty of the COVID‐19 vaccines and the unique current context, studies reported personalized conversations, question periods, and addressing misinformation as important components of the educational approaches reviewed.ConclusionsVarious educational interventions were delivered during the COVID‐19 pandemic, with many initiatives involving multifaceted interventions utilizing both formal and informal approaches that leveraged community (cultural, religious) partnerships when developing and facilitating COVID‐19 vaccine education. Train‐the‐trainer approaches with recognized community members could be of value as trust and personal connections were identified as strong enablers throughout the review.
Longitudinal cardiac remodeling in collegiate American football players as assessed by echocardiography during their collegiate career
Authors: Hamburger Robert F. , Taha Yasmeen , Ruzieh Mohammed , Clugston James R. , Handberg Eileen M. , Reifsteck Fred , Martinez Matthew W. , Pepine Carl J. , Edenfield Katherine M. 
Published: August 2023

AbstractBackgroundStudies on the longitudinal effects of intense physical training on cardiac remodeling are limited, especially in American collegiate football players.HypothesisCollege‐level American football training will result in remodeling in a pattern consistent of a sport with moderate static and dynamic demands with increases in both wall and chamber sizes.MethodsWe studied 85 American collegiate football players who underwent transthoracic echocardiogram (TTE) for asymptomatic or mild COVID‐19‐related illness and compared the changes in echo dimensions to their preparticipation screening TTE. Pre‐ and posttraining variables were compared using a paired t‐test for normally distributed variables.ResultsMean age was 19 years ± 1 and 61% of athletes were Black. Mean follow‐up between TTEs was 21 ± 13 months. There was an increase in left atrial volume index (26.4 ± 5.5 to 32.8 ± 8.4 mL/m2, p < .001), LV end diastolic diameter (5.13 ± 0.4 to 5.27 ± 0.4 cm, p = .003), basal RV diameter (3.28 ± 0.7 to 3.83 ± 0.5 cm, p = <.001), LV mass index (86.7 ± 15.3 to 90.1 ± 15.3, p = .015), and aortic root diameter (3.1 ± 0.4 to 3.2 ± 0.3 cm, p = .03) from pre‐ to posttraining, with a slightly greater magnitude in athletes with >2 years of training. Presence of left atrial enlargement (≥35 mL/m2) increased from 2.9% to 29% pre‐ to postparticipation in athletes with >2 years training. No significant changes in wall thickness, diastolic function, or right ventricular systolic function were observed.ConclusionAmerican football players college‐level training was associated with increases in left and right ventricular chamber sizes, left atrial size, and aortic root diameter.
Less major bleeding and higher hemoglobin after left atrial appendage closure in high‐risk patients: Data from a long‐term, longitudinal, two‐center observational study
Authors: Schach Christian , Reitschuster Raphael , Benedikt Dennis , Füssl Elias , Debl Kurt , Maier Lars S. , Luchner Andreas 
Published: August 2023

AbstractBackgroundLeft atrial appendage closure (LAAC) is a mechanical alternative for stroke prevention in patients at risk who cannot tolerate oral anticoagulation (OAC).HypothesisOur hypothesis was that the reduction of anticoagulation following LAAC results in a decrease of bleeding events and a rise in serum hemoglobin in a high‐risk collective of patients with atrial fibrillation (AF).MethodsBleeding events, use of erythrocyte concentrates, anticoagulation, embolic events, and serum hemoglobin levels before and following LAAC were compared over more than 4 years.ResultsSeventy‐five patients (CHA₂DS₂‐VASc score 4.4 ± 1.7, HAS‐BLED score 4.6 ± 1.1) were analyzed. Before LAAC (observation period 1.8 ± 1.8 years), 67 patients experienced 1.8 ± 1.4 bleeding events (0.9 ± 1.3 major) per year resulting in 0.7 ± 1.3 transfusions per year. After LAAC (2.6 ± 2.0 years), 26 patients (p < .0001 vs. before) had 0.6 ± 2.1 bleeding events (p < .0001), 0.2 ± 0.6 major bleedings (p < .0001) and received 0.6 ± 1.9 transfusions per year (p = .671). Fourteen patients had stroke before and 3 after LAAC (p = .008). Serum hemoglobin increased from initially 9.9 ± 3.0 to 11.9 ± 2.3 g/dL until the end of follow‐up (p = .0005). Adverse embolic events did not differ before and after LAAC in our collective.ConclusionIn this clinical relevant cohort of AF patients with high risk for stroke and intolerance to OAC, we show that LAAC was able to reduce the rate of stroke and bleeding events, which translated into a rising serum hemoglobin concentration.
Inference of causal metabolite networks in the presence of invalid instrumental variables with GWAS summary data
Authors: Chen Siyi , Lin Zhaotong , Shen Xiaotong , Li Ling , Pan Wei 
Published: August 2023

AbstractWe propose structural equation models (SEMs) as a general framework to infer causal networks for metabolites and other complex traits. Traditionally SEMs are used only for individual‐level data under the assumption that all instrumental variables (IVs) are valid. To overcome these limitations, we propose both one‐ and two‐sample approaches for causal network inference based on SEMs that can: (1) perform causal analysis and discover causal relationships among multiple traits; (2) account for the possible presence of some invalid IVs; (3) allow for data analysis using only genome‐wide association studies (GWAS) summary statistics when individual‐level data are not available; (4) consider the possibility of bidirectional relationships between traits. Our method employs a simple stepwise selection to identify invalid IVs, thus avoiding false positives while possibly increasing true discoveries based on two‐stage least squares (2SLS). We use both real GWAS data and simulated data to demonstrate the superior performance of our method over the standard 2SLS/SEMs. For real data analysis, our proposed approach is applied to a human blood metabolite GWAS summary data set to uncover putative causal relationships among the metabolites; we also identify some metabolites (putative) causal to Alzheimer's disease (AD), which, along with the inferred causal metabolite network, suggest some possible pathways of metabolites involved in AD.
Rainfall‐runoff responses and hillslope moisture thresholds for an upland tropical catchment in Eastern Madagascar subject to long‐term slash‐and‐burn practices
Authors: Zwartendijk B. W. , van Meerveld H. J. , Teuling A. J. , Ghimire C. P. , Bruijnzeel L. A. 
Published: August 2023

AbstractSlash‐and‐burn agriculture is an important driver of tropical forest loss and typically results in a mosaic of land uses. However, there is little quantitative information about the hydrological effects of long‐term slash‐and‐burn agriculture and how such mosaics affect the rainfall‐runoff response at the catchment scale. We monitored streamflow responses at two points along a perennial stream in a 31.7 ha catchment in eastern Madagascar that was monitored previously between 1963 and 1972. Land cover in 2015 consisted of degraded grasslands, shrub and tree fallows at various stages of regrowth (64%), eucalypt stands for charcoal production (30%), and rice paddies and wetlands in the valley‐bottom (3%). For the majority (60%) of the events during the study period, the ratio between the total amount of stormflow and rainfall was <3%, suggesting that for these events runoff was generated in the valley‐bottom only. Events for which an antecedent soil moisture storage plus rainfall (ASI + P) threshold was exceeded had much higher stormflow ratios (up to 50%), indicating that a certain wetness was required for the hillslopes to contribute to stormflow. Stable isotope sampling for four small to moderate events indicated that stormflow was dominated by pre‐event water. Total stormflow and annual water yield in 2015 were higher than in the 1960s, despite much lower rainfall in 2015. We attribute these differences to changes in soil physical properties caused by the repeated burning and loss of top‐soil, which has resulted in a reduction in the depth to the impeding layer. The changed runoff‐processes (less infiltration, more saturation‐excess overland flow) thus affect local water resources.
HPVTIMER: A shiny web application for tumor immune estimation in human papillomavirus‐associated cancers
Authors: Liu Liying , Xie Yanan , Yang Hong , Lin Anqi , Dong Minjun , Wang Haitao , Zhang Cangang , Liu Zaoqu , Cheng Quan , Zhang Jian , Yuan Shuofeng , Luo Peng 
Published: August 2023

AbstractThe tumor immune microenvironment (TIME) is closely associated with tumor formation, particularly linked to the human papillomavirus (HPV), and regulates tumor initiation, proliferation, infiltration, and metastasis. With the rise of immunotherapy, an increasing amount of sample data used for TIME exploration is available in databases. However, no currently available web tool enables a comprehensive exploration of the TIME of HPV‐associated cancers by leveraging these data. We have developed a web tool called HPV‐associated Tumor Immune MicroEnvironment ExploreR (HPVTIMER), which provides a comprehensive analysis platform that integrates over 10,000 genes and 2290 tumor samples from 65 transcriptome data sets across 8 cancer types sourced from the Gene Expression Omnibus (GEO) database. The tool features four built‐in analysis modules, namely, the differential expression analysis module, correlation analysis module, immune infiltration analysis module, and pathway analysis module. These modules enable users to perform systematic and vertical analyses. We used several analytical modules in HPVTIMER to briefly explore the role of CDKN2A in head and neck squamous cell carcinomas. We expect that HPVTIMER will help users explore the immune microenvironment of HPV‐associated cancers and uncover potential immune regulatory mechanisms and immunotherapeutic targets. HPVTIMER is available at http://www.hpvtimer.com/.
Evaluation of nutrient assimilative capacity in waterfowl impoundments: The role of environmental stressors
Authors: Wood Rachel L. , Stark John M. , Aanderud Zachary T. , Baker Michelle A. 
Published: August 2023

AbstractThe effectiveness of wetlands in sequestering nutrients and improving water quality relies on a suite of abiotic and biotic conditions. To more fully understand the restraints on nutrient removal, especially salinity and plant cover, we created field‐scale mesocosms and monitored nutrient sequestration with nutrient additions and isotopic pool dilutions over 2 years in two wetlands near the Great Salt Lake in Utah. Surprisingly, we found no differences in nutrient removal with plant removal, increased salinity, and altered ambient nutrient concentrations, suggesting functional redundancy in associated primary producers. When submerged aquatic vegetation was removed, chlorophyll α concentration (0.1–9.0 μg/L) increased while nitrogen (N) and phosphorus (P) assimilation remained the same as phytoplankton occupied the open niche space. We did find ammonium concentrations to be inversely related to nitrate assimilation—as the ammonium concentration increased, nitrate assimilation decreased, suggesting preferential uptake of ammonium. Last, in our high N and P treatment mesocosms, the nitrate dramatically declined from 43.9 mg/L to background levels (<0.1 mg/L) within 1 week, showing a high potential for N remediation in these wetlands.
Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how)
Authors: Little Dianne , Amadio Peter C. , Awad Hani A. , Cone Stephanie G. , Dyment Nathaniel A. , Fisher Matthew B. , Huang Alice H. , Koch Drew W. , Kuntz Andrew F. , Madi Rashad , McGilvray Kirk , Schnabel Lauren V. , Shetye Snehal S. , Thomopoulos Stavros , Zhao Chunfeng , Soslowsky Louis J. 
Published: August 2023

AbstractSeveral tendon and ligament animal models were presented at the 2022 Orthopaedic Research Society Tendon Section Conference held at the University of Pennsylvania, May 5 to 7, 2022. A key objective of the breakout sessions at this meeting was to develop guidelines for the field, including for preclinical tendon and ligament animal models. This review summarizes the perspectives of experts for eight surgical small and large animal models of rotator cuff tear, flexor tendon transection, anterior cruciate ligament tear, and Achilles tendon injury using the framework: “Why, Who, What, Where, When, and How” (5W1H). A notable conclusion is that the perfect tendon model does not exist; there is no single gold standard animal model that represents the totality of tendon and ligament disease. Each model has advantages and disadvantages and should be carefully considered in light of the specific research question. There are also circumstances when an animal model is not the best approach. The wide variety of tendon and ligament pathologies necessitates choices between small and large animal models, different anatomic sites, and a range of factors associated with each model during the planning phase. Attendees agreed on some guiding principles including: providing clear justification for the model selected, providing animal model details at publication, encouraging sharing of protocols and expertise, improving training of research personnel, and considering greater collaboration with veterinarians. A clear path for translating from animal models to clinical practice was also considered as a critical next step for accelerating progress in the tendon and ligament field.
Predictors of 1‐year enteral autonomy in children with intestinal failure: A descriptive retrospective cohort study
Authors: Raghu Vikram K. , Leraas Harold J. , Samoylova Mariya , Park Christine , Rothenberger Scott D. , Sudan Debra , Avitzur Yaron 
Published: August 2023

AbstractIntroductionThe International Intestinal Failure Registry (IIFR) is an international consortium to study intestinal failure (IF) outcomes in a large contemporary pediatric cohort. We aimed to identify predictors of early (1‐year) enteral autonomy.MethodsWe included IIFR pilot phase patients. IF was defined by a parenteral nutrition need for at least 60 days due to a primary gastrointestinal etiology. The primary outcome was time to enteral autonomy achievement. We built a mixed‐effects Weibull accelerated failure time model with random effects by center to analyze variables associated with enteral autonomy achievement with a primary outcome of time ratio (TR).ResultsWe included 189 patients (82% with short bowel syndrome) representing 11 international centers. Cumulative incidence of early enteral autonomy was 51.6%, and death was 6.5%. In multivariable analysis, ostomy presence (TR, 2.63; 95% CI, 1.41–4.90) was associated with increased time to enteral autonomy achievement, and Asian/Indian (TR, 0.28; 95% CI, 0.10–0.81) and Pacific Islander race (TR, 0.34; 95% CI, 0.13–0.90) were associated with decreased time to enteral autonomy achievement. In a second model in the subset with measured percentage of bowel length remaining, ostomy presence (TR, 4.21; 95% CI, 1.90–9.33) was associated with increased time to enteral autonomy achievement, whereas greater percentage of bowel remaining (TR, 0.96; 95% CI, 0.94–0.98) was associated with decreased time to enteral autonomy achievement.ConclusionsMinimizing bowel resection at initial surgery and establishing bowel continuity by ostomy reversal can effectively decrease the time to early enteral autonomy achievement in children with IF.
Lattice dynamics and phase transitions in FAPbBr3 single crystals: Temperature‐ and pressure‐dependent Raman spectroscopy
Authors: Naqvi Furqanul Hassan , Ko Jae‐Hyeon 
Published: August 2023

AbstractThe rapidly emerging perovskites hold immense potential for revolutionizing optoelectronic and photovoltaic applications. However, understanding the complex structural dynamics and their response at extreme conditions in robust environments is crucial for optimizing the practical performance of perovskite‐based devices. Previous X‐ray diffraction studies have shown great potential for studying the average structures of these materials, but for more complex analysis at the local atomic level, Raman spectroscopy is a powerful tool. In this study, temperature‐ and pressure‐dependent Raman spectroscopy was used to elucidate the intricate lattice dynamics, phase transitions, and amorphization of FAPbBr3 single crystals at extreme conditions such as low temperature or high pressure. Temperature‐dependent Raman spectra unveiled significant variations in wavenumbers, full width at half maximum, and the vanishing of specific modes at higher temperatures. These were ascribed to symmetry changes caused by two crystallographic phase transitions at −127°C from orthorhombic to tetragonal and at −33°C from tetragonal to cubic phase. In addition, some of the Raman modes disappeared upon heating at −90°C, which was associated with a crystallographically unresolved transition. Pressure‐dependent Raman scattering revealed two phase transitions at 0.3 GPa and 2.2 GPa, which corresponded to the contraction of the PbBr6 octahedra and their tilting distortion, respectively. Further compression uncovered amorphization at 3.6 GPa, characterized by the vanishing of crystalline Raman modes together with the emergence of broad new modes due to the disorder within the crystal structure. Upon pressure release, the original Raman modes were recovered, indicating the reversibility of the pressure‐induced phase transitions. The changes in the Raman spectra were the most significant, especially in the low‐wavenumber lattice modes, when the FAPbBr3 underwent orthorhombic phase transition. It indicates that the inorganic sublattice is affected by the structural change into the orthorhombic phase caused either by temperature or pressure variation.
Heterotopic intestine and abdominal wall transplantation in a miniature swine: A model for graft immunology
Authors: Kuo Yur‐Ren , Chen Yu‐Han , Yeh Yung‐Sung , Chang Chao‐Wei , Li Ching‐Chun , Cai Ting‐Yu , Chang Han‐Ching , Chang Yu‐Tang 
Published: August 2023

AbstractIn order to accurately monitor graft immunology, we have developed a method for performing intestine and abdominal wall transplantation heterotopically in miniature swine. The procedure consisted of simultaneous segmental terminal ileum and full‐thickness abdominal wall transplantation in Lanyu miniature swine, with the intestinal and the abdominal wall grafts being placed on the recipient's bilateral rear flank. Five transplantations were technically successful. One animal died on the first post‐transplant day due to anesthesia‐related issues, three abdominal wall and four intestinal grafts survived, while one abdominal wall graft failed due to vascular thrombosis. Acute cellular rejection (ACR) of the intestinal graft could occur preceding, simultaneously with or following ACR of the abdominal wall graft. Our experimental model demonstrates the technical feasibility of heterotopic intestine and abdominal wall transplantation in miniature swine without grafting in gastrointestinal continuity. This model could be suitable for further studies of graft immunology.