bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co‐model for chemical toxicity prediction based on multi‐task deep learning
Authors: Yuan Li Yuan , Chen Lingfeng , Pu Chengtao , Zang Chengdong , Yan YingChao , Chen Yadong , Zhang Yanmin , Liu Haichun 
Published: February 2023

AbstractThe toxicity of compounds is closely related to the effectiveness and safety of drug development, and accurately predicting the toxicity of compounds is one of the most challenging tasks in medicinal chemistry and pharmacology. In this paper, we construct three types of models for single and multi‐tasking based on 2D and 3D descriptors, fingerprints and molecular graphs, and then validate the models with benchmark tests on the Tox21 data challenge. We found that due to the information sharing mechanism of multi‐task learning, it could address the imbalance problem of the Tox21 data sets to some extent, and the prediction performance of the multi‐task was significantly improved compared with the single task in general. Given the complement of the different molecular representations and modeling algorithms, we attempted to integrate them into a robust Co‐Model. Our Co‐Model performs well in various evaluation metrics on the test set and also achieves significant performance improvement compared to other models in the literature, which clearly demonstrates its superior predictive power and robustness.
Long‐Term High‐Fat Diet Decreases Renal Insulin‐Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway
Authors: Su Qian , Huang Juan , Chen Xi , Wang Yijie , Shao Muqing , Yan Hongjia , Chen Caiyu , Ren Hongmei , Zhang Fuwei , Ni Yinxing , Jose Pedro A. , Zhong Jian , Yang Jian 
Published: February 2023

ScopeLong‐term high‐fat diet (HFD) causes insulin resistance, which is a primary etiological factor in the development of obesity and type 2 diabetes mellitus. Impaired insulin clearance is not only a consequence but also a cause of insulin resistance. The kidney is a major site of insulin clearance, where the insulin‐degrading enzyme (IDE) plays a vital role in the proximal tubule. Thus, the study investigates the role of renal IDE in the regulation of insulin resistance in HFD‐induced obese mice.Methods and resultsTwenty four‐weeks of HFD in C57BL/6 mice causes insulin resistance and impaires insulin clearance, accompanied by a decrease in renal IDE expression and activity. Palmitic acid decreases IDE mRNA and protein expressions in HK‐2 cells. RNA‐Seq analysis found that the PPAR pathway is involved. 24‐weeks of HFD decreases renal PPARγ, but not PPARα or PPARβ/δ mRNA expression. The inhibition of IDE expression by palmitic acid is prevented by the PPARγ agonist rosiglitazone. The amount of PPARγ bound to the promoters of IDE is decreased in palmitic acid‐treated cells. Rosiglitazone improves insulin clearance and insulin resistance and increases renal IDE expression in HFD fed‐mice.ConclusionLong‐term HFD decreases renal IDE expression and activity, and causes insulin resistance, which involves PPARγ.
Gender differences in the associations between knee pain and urinary incontinence in older adults: Cross‐sectional analysis from the Malaysian Elders Longitudinal Research Study (MELoR)
Authors: Mat Sumaiyah , Jaafar Mohamad Hasif , Razack Azad H. A. , Lim Jasmine , Ong Teng Aik , Khong Su‐Yen , Kamaruzzaman Shahrul Bahyah , Chin Ai‐Vyrn , Abbas Azlina Amir , Chan Chee Ken , Hairi Noran Naqiah , Othman Sajaratulnisah , Tan Maw Pin ,   the MELoR investigators
Published: February 2023

AbstractIntroductionThe common assumption that urinary incontinence occurs in osteoarthritis (OA) due to poor mobility is supported by limited evidence. The influence of gender in such associations is also yet to be elucidated.ObjectiveThis study, therefore, identified any potential associations between knee OA symptoms and urinary incontinence and further explore sex differences in the associations.DesignCross‐sectional study.SettingUniversity Hospital.ParticipantsThis was a cross‐sectional study from a longitudinal research study comprising 1221 community‐dwelling older persons (57% women), mean age (SD) 68.95 (7.49) years.Main Outcome Measure(s)Presence of urinary incontinence: mixed, stress and urge symptoms. Physical performance and C‐reactive protein levels were also assessed.ResultsTwo hundred and seventy‐seven (22.83%) individuals reported the presence of urinary incontinence: mixed (41.5%), stress (30%), and urge (28.5%) symptoms. In an unadjusted analysis, stratified by gender, the association between knee pain and urinary incontinence was only present in women with mixed symptoms. After further adjustment of demographics differences and body mass index, the association between knee pain with any urinary incontinence and mixed symptoms remained significant with the odds ratios (95% confidence interval): 1.48 (1.02–2.15) and 1.73 (1.06–2.83), respectively. This relationship was attenuated after further adjustment for waist circumference and impaired lower limb mobility.ConclusionOur study refutes previous assumptions that urinary incontinence in individuals with OA is attributed to impaired mobility alone, but introduces the role of abdominal obesity in this relationship, particularly in women. Future studies should assess the temporal relationship between body fat distribution and OA with urinary incontinence.
Preoperative electrodiagnostic studies and postoperative outcomes for ulnar mononeuropathy at the elbow: A systematic review
Authors: Meiling James B. , Schappell Justin B. , Twohey Eric E. , Prokop Larry J. , Cushman Daniel M. 
Published: February 2023

AbstractObjectiveTo analyze the association between preoperative electrodiagnostic (EDX) studies and postoperative pain and functional outcomes following ulnar nerve decompression and/or transposition for ulnar neuropathy at the elbow (UNE).Literature SurveyProtocol was submitted and database search was conducted by an experienced librarian of all available studies in the English language from 1990 to June 8, 2022. Databases included Ovid MEDLINE(R) and Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations and Daily, Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, and Scopus.MethodologyInclusion criteria consisted of randomized controlled trials, prospective and retrospective longitudinal studies, and studies involving adults ≥18 years of age who underwent ulnar nerve decompression and/or transposition for UNE. Study quality and risk of bias were assessed using the National Heart, Lung, and Blood Institute (NHLBI) Study Quality of Assessment Tool. Certainty in evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. A meta‐analysis was not performed.SynthesisA total of 289 studies were screened, and 8 retrospective cohort studies met inclusion criteria comprising 762 patients. A decreased or absent preoperative sensory nerve action potential amplitude (SNAP) showed significance with worse postoperative outcomes. The presence of preoperative conduction block showed significance in higher quality studies. There was limited evidence for slow preoperative motor conduction velocities or preoperative electromyography (EMG) abnormalities and postoperative outcomes. Overall quality assessment demonstrated that two studies had “good,” four “fair,” and two “poor” quality of evidence. Certainty in evidence was “low” due to risk of bias.ConclusionsA decreased or absent preoperative ulnar SNAP may predict worse postoperative outcomes. Per higher quality studies, preoperative conduction block at the elbow may also predict worse postoperative outcomes. Careful interpretation is required with a full understanding of the limited evidence, risk of bias, and low certainty in evidence to support the use of preoperative EDX to predict postoperative outcomes in UNE.
Cell‐level systems biology model to study inflammatory bowel diseases and their treatment options
Authors: Stübler Sabine , Kloft Charlotte , Huisinga Wilhelm 
Published: February 2023

AbstractTo help understand the complex and therapeutically challenging inflammatory bowel diseases (IBDs), we developed a systems biology model of the intestinal immune system that is able to describe main aspects of IBD and different treatment modalities thereof. The model, including key cell types and processes of the mucosal immune response, compiles a large amount of isolated experimental findings from literature into a larger context and allows for simulations of different inflammation scenarios based on the underlying data and assumptions. In the context of a large and diverse virtual IBD population, we characterized the patients based on their phenotype (in contrast to healthy individuals, they developed persistent inflammation after a trigger event) rather than on a priori assumptions on parameter differences to a healthy individual. This allowed to reproduce the enormous diversity of predispositions known to lead to IBD. Analyzing different treatment effects, the model provides insight into characteristics of individual drug therapy. We illustrate for anti‐TNF‐α therapy, how the model can be used (i) to decide for alternative treatments with best prospects in the case of nonresponse, and (ii) to identify promising combination therapies with other available treatment options.
Multi‐state reliability assessment for shipboard hybrid turbine‐diesel generation system with redundancy and aging effects
Authors: Xu Yifan , Shi Yuedong , Xiong Zihao , Yang Haojie 
Published: February 2023

AbstractComplex system structures, dynamic energy demands, and tough operating environment pose a huge challenge to reliability assessment and risk control. Taking multi‐state, redundant structure and aging impact into account, reliability assessment for shipboard hybrid turbine‐diesel generation system is studied. This work adopts a comprehensive method combining the Markov method and universal generating function (UGF): the Markov method is used for reliability modeling at the unit level, and then synthesized and calculated through UGFs to obtain system‐level reliability. Based on the above methodology, this work presents a multi‐state system (MSS) model with different configuration structures and failure rate types, then compares the availability evaluation results of the single power generation system, the hybrid power system with redundancy and aging effects. The results show that (1) redundant design effectively improves system availability to meet power supply requirements; (2) in the case of system aging and imperfect repair, redundant configuration and power distribution can significantly improve the availability of power supply to be almost unaffected by aging, and effectively reduce the risk of performance failure; and (3) when the redundancy is applied, the system power supply availability is not sensitive in the high‐value range of the redundant installed capacity ratio, but sensitive in the high‐value range of effective coefficient about power compensation control.
Evaluating the efficiency of power‐series expansions as model potentials for finite‐temperature atomistic calculations
Authors: Bichelmaier Sebastian , Carrete Jesús , Madsen Georg K. H. 
Published: February 2023

AbstractGiven the cost of ab‐initio calculations, predictive studies of temperature‐dependent phenomena in strongly anharmonic systems pose a serious challenge. Using a relatively inexpensive surrogate model for the potential energy surface to build temperature‐dependent effective harmonic potentials is a possible solution. Automatic differentiation makes high‐order Taylor potentials as surrogate models a relatively accessible possibility. Here Lennard‐Jones clusters and solids are used as a test bench on which to perform a detailed analysis of such a procedure. It is found that results might only be valid in a narrow temperature regime, outside of which the local nature of Taylor expansions leads to drastic artifacts in the free energies and derived quantities such as the thermal expansion. Those shortcomings are traced to the limited flexibility of polynomials as approximants and are therefore fundamental. The observed behavior is confirmed using density functional theory on a five‐atom silver cluster. A global interpolation strategy, in the form of a neural‐network force field, is suggested as a better path to cost‐effective surrogate models.
Surgical accuracy and clinical outcomes of image‐free robotic‐assisted total knee arthroplasty
Authors: Lau Cyrus Tsun‐Kit , Chau Wai‐Wang , Lau Lawrence Chun‐Man , Ho Kevin Ki‐Wai , Ong Michael Tim‐Yun , Yung Patrick Shu‐Hang 
Published: February 2023

AbstractBackgroundThe development of total knee arthroplasty (TKA) for knee osteoarthritis (OA) has a good reputation for its effectiveness in reducing joint pain and improving range of motion. We aimed to review our early results using the image‐free robotic‐assisted technology in knee arthroplasty.MethodsA total of 71 patients suffering from end‐stage OA knee receiving TKA operated by robotic‐assisted surgery between the years 2018 and mid‐2021 were recruited. Clinical and radiological outcomes were compared with age and sex‐matched control group (conventional TKA).ResultsThe radiological outcome showed significantly more postoperative lower limb alignment outliers in conventional side than robotic‐assisted sides. Postoperative knee scores were similar among both groups. Robotic‐assisted TKA required a longer implantation time but a shorter hospital stay.ConclusionRobotic‐assisted TKA achieved a lower rate of mechanical axis Outlier in the coronal and sagittal plane with a shorter hospital stay. Yet both methods achieve a similar functional outcome.
Experimental study of aggregate size and gradation on pervious concretes' mechanic, hydraulic, and surface properties
Authors: Yavuz Demet , Yazıcı Şemsi 
Published: February 2023

AbstractAs environmental impacts of materials in concrete construction have been an aspect that has been focused on lately, pervious concrete has been implemented widely around the world. Recently, as a reflection of this trend, research and application of pervious concrete have been multiplied. Pervious mixes are mostly being used on low traffic load environments such as pavements, parking lots, and greenhouses. Because of this inclination 10 ± 1.5 MPa is chosen in this study for target compressive strength. The aim of this study is to investigate the effect of aggregate type and gradation on pervious concrete properties with target compressive strength of 10 ± 1.5 MPa. Three different coarse aggregate types (limestone, river, and recycled) and three different fractions (15–25, 10–15, and 5–15 mm) were considered. Recycled coarse aggregates were obtained from the previous mixes with limestone coarse aggregates produced for this study. Mechanical properties such as compressive strength, splitting tensile and flexural strength, density, void content, abrasion strength, and drying shrinkage were determined. Results showed that it is possible to have similar compressive strength and higher void content for the pervious mixes produced with coarse recycled aggregates. While river coarse aggregates showed better quality for drying shrinkage, coarse limestone aggregates were more abrasion resistant.
Environmental Governance as Knowledge Co-production: The Emergence of Permaculture Movements in Indonesia
Authors: Hapsari Maharani 
Published: February 2023

AbstractCurrent academic debate witnessed the salience of looking at the epistemic dimension of environmental governance. In such setting, this study learns from how knowledge co-production works in the emergence of permaculture movements in Indonesia. The method of this study departs from the concept of knowledge co-production and situates it within the broader literatures on social movement and counter-hegemonic politics. The data is based on the experiences of four permaculture communities in Indonesia, namely Bumi Langit Institute, Sendalu Permaculture, IDEP Foundation, and Jiwa Damai. This study argues that the formation of permaculture movements in Indonesia involves negotiated boundaries among different ways of knowing in the epistemic relations surrounding permaculture practices. The critical distancing that develops between the movements and the hegemonic knowledge structure seeks to transform agro-industrial knowledge practices toward an alternative knowledge system. The quest of epistemic leadership is constructed through the porous boundaries of knowledge co-production toward defining what permaculture means as a collective project.
The Conceptual Models of Dynamic Governance Toward Sustainable Urban Water Management in Metropolitan Area
Authors: Mulyana Wahyu , Prasojo Eko , Suganda Emirhadi , Moersidik Setyo Sarwanto 
Published: February 2023

AbstractWater is a key resource needed for human life. Urban water supply has not met the target of fulfilling water rights in terms of quantity, quality, continuity, and affordability. Urban water management system still traditionally emphasizes the physical construction of infrastructure and are still managed fragmented. This research aims to develop the conceptual models of dynamic governance model in urban water governance. The research approach uses a qualitative method by using soft system methodology (SSM) to develop the conceptual model. Research results are the conceptual models of dynamic governance in urban water governance at the policy hierarchy process starting from policy, organizational and operational levels to achieve the goals of sustainable urban water management. The conceptual models are described through the pathways of activities based on the interaction between dynamic capabilities and organizational culture. The dynamic governance model is adapted in Bandung Metropolitan Area as an implementation strategy in the fast-growing urban area.
Local Resource Governance: Strategies for Adapting to Change
Authors: Turner-Walker Skye 
Published: February 2023

AbstractClimate change is significantly impacting local communities throughout Indonesia that are dependent on access to ecosystems and weather-dependent resources. This chapter explores how local resource governance systems shape responsiveness and adaptive capacity of communities to pressures and change. Drawing on two comparative cases studies of coastal communities in Indonesia, this chapter conveys how active responses to environmental pressures and change over resource and land conflict, are indicative of adaptive capacity and how communities are likely to adapt to climate change impacts. The chapter argues through illustrative examples that local resource governance determines innovation and engagement through collective handling, reciprocity, cooperation and coordinated action, in order to adjust and adapt in dealing with environmental pressures, elite capture, conflict and change.
Local Governance of Sustainability Transition in Community-Scale Solar Water Pumping Systems in Indonesia
Authors: Rahmani Sita , Murayama Takehiko , Nishikizawa Shigeo , Roychansyah Muhammad Sani 
Published: February 2023

AbstractSustainability transition emerges in various types of community-scale projects. Indonesia has been actively implementing solar water pumping systems (SWPS) since 1982. However, for almost four decades, SWPS, as a niche innovation, have not achieved significant adoption of solar technology in the water utility sector. This study aimed to assess local governance aspects of SWPS in the context of sustainability transition from two perspectives: internal niche management and local actors. We assessed nine SWPS projects in Yogyakarta Province, Indonesia, using structured interviews that were analyzed using descriptive statistics and qualitative content analysis. The results showed that the discontinuation of support made SWPS unsustainable, operating only for an average of 4 years. Crucial operational factors included electrical damage, insufficient training, and lack of funds for damage repair. The iterative process of learning, network building, and vision did not eventuate. SWPS have direct benefit on the water supply; however, technological performance feedback related to the karst environment was insufficiently addressed and the network of actors did not expand to higher levels of local government. SWPS were viewed as an unreliable technology; hence, there was no vision for applying SWPS as a water utility. Solar photovoltaic pumps need strong support to compete with diesel and electrical water utility pumps. To achieve sustainability transition, it is imperative to generate vision, promote policy change, and build committed networks within local government rather than simply replicate the number of project installations.
Coastal Forest Re-Grabbing: A Case from Langkat, North Sumatra, Indonesia
Authors: Adhuri Dedi S. , Syafi’i Imam , Rahmayanti Atika Zahra , Putri Intan Adhi Perdana , Nadjib Mochammad 
Published: February 2023

AbstractGrabbing in its various forms, such as land and maritime grabbing, has been a global concern. This is not only because it happened in many places but also the negative impacts on local people and the environment were often severe. Studies found that millions of local people were excluded from their access to resources they depended upon for decades or even generations. In some places, environmental impact occurred beyond the ability of the ecosystem to recover. This paper will also deal with the above issues. Nonetheless, while most studies focus on grabbing and their socio-environmental impacts, this paper will demonstrate the process of “re-grabbing.” This is how local community supported by NGOs and other agencies took back the control over the coastal mangrove forest taken and converted by a private company for palm oil plantation. This paper will explain the process and strategies employed by coastal communities in Langkat, North Sumatra, in resisting the palm oil plantation’s presence that has impacted their fishing and coastal livelihoods seriously. Interestingly, one of the strategies was “destroy and rehabilitate.” This is the destruction of coastal dikes and palm oil trees and the reestablishment of the mangrove forest. This strategy bears two results. The first is the recovery of the ecosystem, which supports the redevelopment of coastal livelihoods, the old and new. Second is the acknowledgment from the government on the fact that communities have rehabilitated the coastal mangrove well. This, in turn, has stimulated government to grand the communities the Hak Perhutanan Sosial (Social Forestry Right) to manage the designated forest. In conclusion, this paper will argue despite the fact that in most cases grabbing left the community and environment as the lost parties, with certain strategies the reality can be turned back for the favor of the communities and the environment.