bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managerial practices and school efficiency: a data envelopment analysis across OECD and MENA countries using TIMSS 2019 data
Authors: Bhutoria Aditi , Aljabri Nayyaf 
Published: December 2022

AbstractSchool-level inefficiencies and mismanagement can have serious repercussions for human resource development and labor market outcomes. This paper investigates the extent and consequences of existing technical inefficiency of schools with respect to their resource- and people-management aspects at a cross-country level across Organisation for Economic Cooperation and Development (OECD) and the Middle East and North Africa (MENA) regions. It employs a non-radial Data Envelopment Analysis (DEA) alongside a second stage Tobit regression model using datasets in the latest Trends in International Mathematics and Science Study (TIMSS) 2019. The analysis covers 5164 schools across 26 countries. In the first stage of DEA analysis, it is evident that technical inefficiencies exist similarly across schools of both OECD and MENA nations, irrespective of the method used for efficiency calculation. While availability of educational resources is a necessary condition for improving learning outcomes, it is surely not sufficient. In the second stage of the Tobit regression, the model confirms that improved utilization of the existing resources through better educational management systems can yield higher cognitive achievement at the school-level. The empirical findings also reveal that discipline maintained within the student body at school is one of the most important and significant factors associated with higher school level input- and output-efficiency across both MENA and OECD regions. Moreover, different aspects of people management, particularly target setting, student as well as teacher motivation, and parental involvement in school management are found to be positively associated with school-level technical efficiency across the two regions, albeit in varying degrees. Overall, educational management policies should shift focus from solely providing higher quantity of resources to improving the technical efficiency of schools through enhanced school-level management, by encouraging disciplinary action, as well as by supporting stakeholder incentives that foster motivation and participation.
Adherence to methotrexate and associated factors considering social desirability in patients with rheumatoid arthritis: a multicenter cross-sectional study
Authors: Yajima Nobuyuki , Kawaguchi Takashi , Takahashi Ryo , Nishiwaki Hiroki , Toyoshima Yoichi , Oh Koei , Odai Tsuyoshi , Kanai Takayuki , Morisky Donald E. , Yamaguchi Takuhiro , Kasama Tsuyoshi 
Published: December 2022

Abstract
Background
Assessing medication adherence in rheumatoid arthritis (RA) is clinically significant as low adherence is associated with high disease activity. Self-reported medication adherence surveys have been shown to have problems with overestimation of adherence due to social desirability bias. However, no MTX adherence studies adjusted for social desirability have been conducted to date. This study aimed to evaluate adherence to MTX and perform an investigatory search for factors associated with MTX adherence including social desirability.

Methods
This cross-sectional multicenter study was conducted among adult RA patients consuming oral MTX for ≥ 3 months. We examined the distribution of MTX adherence, according to the eight-item Morisky Medication Adherence Scale (MMAS-8). Social desirability was using the Social Desirability Scale (SDS). Furthermore, an exploratory factor analysis involving social desirability was examined to identify factors associated with MTX adherence using linear regression analysis. To deal with missing values, we used multiple imputations with chained equations methods.

Results
A total of 165 RA patients were enrolled. The median age was 64 years, and 86.1% were women. Based on the MMAS-8, low, medium, and high adherences were noted in 12.1%, 60.0%, and 27.9% of participants, respectively. High social desirability (coefficient, 0.14; 95% confidence interval [CI], 0.05–0.23; p < 0.05) and high age (coefficient per 10 years, 0.16; 95% CI, 0.01–0.03; p < 0.05) were associated with high MTX adherence, whereas full-time work was negatively associated with high MTX adherence (coefficient, -0.50; 95% CI, -0.95–-0.05; p < 0.05).

Conclusions
A large proportion of patients with RA do not take MTX as prescribed. High social desirability, high educational level, and non-full-time work may be associated with high MTX adherence. Physicians should confirm MTX adherence before switching or adding disease-modifying anti-rheumatic drugs in cases of uncontrolled disease activity.
The evaluation of the analgesic effect of intraperitoneal bupivacaine versus bupivacaine with neostigmine on postoperative pain in laparoscopic cholecystectomy: a randomized controlled double-blinded study
Authors: Arafa Mohamed S. , Ahmed Hassan Mohamed , Elnabawy Abdelrahman Bakr , Kassem Sara Farouk 
Published: December 2022

Abstract
Background
This study aimed to compare the duration of postoperative analgesia using intraperitoneal bupivacaine plus neostigmine or bupivacaine alone. In this randomized controlled trial, we included 56 adult patients scheduled for elective laparoscopic cholecystectomy operation. Patients were randomly allocated into two groups bupivacaine group (B group) who received 50 ml bupivacaine 0.25% alone and bupivacaine-neostigmine group (BN group) who received 500 μg neostigmine added to 50 ml bupivacaine 0.25%. The study drug was instilled intraperitoneal according to group allocation before the start of the surgery. Primary outcome was the duration of analgesia. Other outcome included total dose of postoperative analgesic consumption and postoperative nausea and vomiting.

Results
Patients in BN group showed longer duration of analgesia after surgery and longer time for 1st analgesic dose than the patients in B group. Total dose of postoperative pethidine and the incidence of postoperative nausea and vomiting were lower in number in the BN group than in the B group.

Conclusions
Intraperitoneal instillation of neostigmine as an adjunct to bupivacaine in elective laparoscopic cholecystectomy increased the duration of postoperative analgesia. Also, it might reduce postoperative pain and analgesic requirements as compared to bupivacaine 0.25% alone.

Trial registration
Name of the registry: Clinical trial
Clinical Trial registration number: NCT04244097
Date of registration: 28 January 2020
URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT04244097
Determination of regulatory motifs and pathogenicity of intronic variants of GNPTAB, GNPTG, and NAGPA genes in individuals with stuttering
Authors: Sylvester Charles , Kundapur Rajesh , Maruthy Santosh 
Published: December 2022

AbstractBackgroundStuttering is a fluency disorder typically characterized by part-word repetitions, voiced or voiceless sound prolongations, and broken words. Evidence suggests that 1% of the world population stutters. Compelling evidence from past research suggests that stuttering is caused by non-synonymous coding sites. This study evaluates the intronic regions ofGNPTAB, GNPTG,andNAGPAgenes for possible pathogenicity of intronic variants from unrelated non-syndromic stutterers in a cohort of the south Indian population.ResultsHigh-throughput sequencing revealed 41 intronic variants. Computational tool Reg-SNP Intron identified three intronic variants rs11110995 A>G, rs11830792 A>G, and rs1001171 T>A of having a plausible pathogenic impact which was identified in 37.9%, 26.5%, and 59.4% of stutterers, respectively. RegulomeDB identified the regulatory motifs and susceptible loci of the intronic variants.ConclusionsThis study imparts the identification, association, and interpretation of pathogenicity and regulatory significance of the intronic variants in the context of the noncoding DNA elements. Future work is warranted to better understand the role of the intronic variants in a larger cohort of stutterers, and a cohort of fluent controls would be valuable.
Effect of Mannan-rich fraction supplementation on commercial broiler intestinum tenue and cecum microbiota
Authors: Leigh Robert J. , Corrigan Aoife , Murphy Richard A. , Walsh Fiona 
Published: December 2022

Abstract
Background
The broiler gastrointestinal microbiome is a potent flock performance modulator yet may also serve as a reservoir for pathogen entry into the food chain. The goal of this project was to characterise the effect of mannan rich fraction (MRF) supplementation on microbiome diversity and composition of the intestinum tenue and cecum of commercial broilers. This study also aimed to address some of the intrinsic biases that exist in microbiome studies which arise due to the extensive disparity in 16S rRNA gene copy numbers between bacterial species and due to large intersample variation.

Results
We observed a divergent yet rich microbiome structure between different anatomical sites and observed the explicit effect MRF supplementation had on community structure, diversity, and pathogen modulation. Birds supplemented with MRF displayed significantly higher species richness in the cecum and significantly different bacterial community composition in each gastrointestinal (GI) tract section. Supplemented birds had lower levels of the zoonotic pathogens Escherichia coli and Clostridioides difficile across all three intestinum tenue sites highlighting the potential of MRF supplementation in maintaining food chain integrity. Higher levels of probiotic genera (eg. Lactobacillus and Blautia) were also noted in the MRF supplemented birds. Following MRF supplementation, the cecum displayed higher relative abundances of both short chain fatty acid (SFCA) synthesising bacteria and SCFA concentrations.

Conclusions
Mannan rich fraction addition has been observed to reduce the bioburden of pathogens in broilers and to promote greater intestinal tract microbial biodiversity. This study is the first, to our knowledge, to investigate the effect of mannan-rich fraction supplementation on the microbiome associated with different GI tract anatomical geographies. In addition to this novelty, this study also exploited machine learning and biostatistical techniques to correct the intrinsic biases associated with microbiome community studies to enable a more robust understanding of community structure.
President's Paragaphs: HASTI’s Preservice Teacher Scholarship:
Authors: Hootman Stacy 
Published: December 2022

The author utilized HASTI's Preservice Teacher Scholarship to bring their science methods students to the annual HASTI conference. Results were overwhelmingly positive. The author encourages all science educators to share HASTI's annual conference with any preservice or beginning teachers to help get them connected to a group of dedicated science educators and to help develop their commitment to professional development and sense of professional identity.
Pomen pandemije covida-19 za duševno zdravje medicinskih sester in zdravnikov:
Authors: Višič Uroš , Sočan Maja 
Published: December 2022

Uvod: Pandemijo covid-19 povezujemo s povečanim tveganjem za posttravmatsko stresno motnjo pri zdravstvenih delavcih. Namen sistematičnega pregleda literature je prepoznati vpliv pandemije covida-19 na duševno zdravje v tej populaciji.Metode: Uporabljen je bil sistematičen pregled literature. Iskanje je potekalo od novembra 2020 do januarja 2021. Vključene so bile naslednje iskalne zbirke podatkov: Pubmed, Ebsco, Ovid in Google Scholar. Pri iskanju so bile uporabljene kombinacije ključnih besed: samopodoba, strah, preventiva, medicinske sestre, zdravniki. Uporabili smo diagram PRISMA za prikaz poteka pregleda literature. Tematska analiza je potekala na način kodiranja rezultatov.Rezultati: Iz celotnega iskalnega niza več tisoč člankov smo v končno analizo prenesli štirinajst člankov. Prevalenca anksioznosti med zdravstvenimi delavci je 12,3–35,6 %. Zdravstveni delavci moškega spola so imeli bistveno blažje simptome tesnobe kot ženske. Stopnja tesnobe je bila višja v zdravstveni negi, vendar so bili pri moških manj izraziti simptomi tesnobe kot pri ženskah.Diskusija in zaključek: Pandemija covid-19 je povzročila duševne obremenitve zdravstvenih delavcev. Za obvladovanje duševnega zdravja pri medicinskih sestrah in zdravnikih je treba vključiti preventivne psihoedukativne ukrepe, kot sta briefing in teambuilding.
Prepričanja in implementacija na dokazih podprte prakse med visokošolsko izobraženimi medicinskimi sestrami in zdravstveniki (2. del)
Authors: Skela-Savič Brigita , Lobe Bojana , Bole Urban 
Published: December 2022

Uvod: Zaposleni v zdravstveni negi še vedno niso dovolj opolnomočeni s kompetencami o dokazih podprti praksi. Namen raziskave je bil prepoznati dejavnike, ki oblikujejo prepričanja in tudi implementacijo na dokazih podprte prakse medicinskih sester na vseh ravneh zdravstvenega varstva v Sloveniji.Metode: Izvedena je bila presečna raziskava. Uporabljeni sta bili dve lestvici, in sicer »Evidenced based practice Beliefs Scale and the Implementation Scale«. Sodelovalo je 1014 visokošolsko izobraženih medicinskih sester in zdravstvenikov z vseh treh nivojev zdravstvenega varstva. Podatke smo obdelali z opisnimi, eksplorativnimi in eksplikativnimi statističnimi metodami.Rezultati: O raziskovanju na področju zdravstva se je izobraževalo n = 325 (38,8 %) anketirancev, o dokazih podprti praksi n = 280 (34 %) anketirancev. Pozitivna prepričanja o dokazih podprte prakse pojasnijo samoocena znanja o dokazih podprti praksi (β = 0,249) in raziskovanju (β = 0,162), leta zaposlitve (β = –0,124), zadovoljstvo z delom (β = 0,117), izobraževanje o dokazih podprti praksi (β = 0,092) in izobrazba strokovni magisterij (β = 0,077). Pogostejšo implementacijo pojasnijo pozitivna prepričanja o dokazih podprte prakse (β = 0,306) in zaposlitev v zdravstvenem domu (β = 0,132). Diskusija in zaključek: Pomanjkanje znanja o raziskovanju in dokazih podprte prakse se pokažeta kot najtrdnejša napovedna dejavnika za razvoj prepričanj, medtem ko so pozitivna prepričanja trden napovednik za pogostejšo implementacijo na dokazih podprte prakse. Karierni razvoj medicinskih sester in zdravstvenikov na primarni ravni, ki je osredinjen na prevzem novih nalog, se pokaže kot pomemben dejavnik implementacije na dokazih podprte prakse med vključenimi v raziskavo.
Pemanfaatan Media Online Sebagai Sumber Bahan Ajar Mata Kuliah Dokkai Sakubun Shokyu
Authors: Asrini Dwi Puji , Setiawati Ai Sumirah 
Published: December 2022

The purpose of learning Dokkai Sakubun, is no longer just being able to read and understand vocabulary, kanji, bunkei, hyogen and also use them in sentences. Along with its development, this course aims to make students able to apply the knowledge gained from reading activities into writing that can be expressed in everyday life. In this digital era, teachers can take advantage of all the information available in cyberspace as a source of teaching materials. This research is a descriptive study with the aim of utilizing online media as a source of teaching materials in the Dokkai Sakubun Shokyu Course and compiling teaching materials with sources from online media. This research method is descriptive qualitative, with data collection techniques in the form of questionnaires and direct observation. Questionnaires were given to determine students' perceptions of the use of teaching language sources from online media in learning Dokkai Sakubun Shokyu. Direct observations were made to strengthen the results of the questionnaire regarding the benefits of media in learning and compiling learning materials. The results showed that online media can be used as a source of teaching materials in the Dokkai Sakubun Shokyu Course. Teaching materials are selected based on predetermined topics in the form of videos sourced from YouTube, leaflets, famlets, brochures, tickets, restaurant menus, conversations in email or chat and so on, then arranged in the form of handouts.
Implementing Markovian models for extendible Marshall–Olkin distributions
Authors: Sloot Henrik 
Published: December 2022

Abstract
We derive a novel stochastic representation of exchangeable Marshall–Olkin distributions based on their death-counting processes. We show that these processes are Markov. Furthermore, we provide a numerically stable approximation of their infinitesimal generator matrices in the extendible case. This approach uses integral representations of Bernstein functions to calculate the generator’s first row, and then uses a recursion to calculate the remaining rows. Combining the Markov representation with the numerically stable approximation of corresponding generators allows us to sample extendible Marshall–Olkin distributions with a flexible simulation algorithm derived from known Markov sampling strategies. Finally, we benchmark an implementation of this Markov-based simulation algorithm against alternative simulation algorithms based on the Lévy frailty model, the Arnold model, and the exogenous shock model.
Reifegradmodelle im Forschungsdatenmanagement – IT-Prozessoptimierung im Wissenschaftsbetrieb
Authors: Lehmann Anna , Odebrecht Carolin 
Published: December 2022

Zusammenfassung
Kontinuierliche Veränderungen des institutionellen Forschungsdatenmanagements stellen dienstleistende Einrichtungen an Hochschulen vor die Herausforderung, ihre Services zu professionalisieren. In einer vergleichenden Analyse wird herausgearbeitet, welche Reifegradmodelle in welchem Maße dafür geeignet sind. Für diesen Vergleich werden Analysekriterien entwickelt, die gleichermaßen das Forschungsdatenmanagement sowie das IT-Service Management in den Betrachtungsmittelpunkt stellen. Abschließend werden herausgearbeitete Vorteile und entdeckte Interferenzen der Modelle diskutiert.
On the reciprocal sum of the fourth power of Fibonacci numbers
Authors: Hwang WonTae , Park Jong-Do , Song Kyunghwan 
Published: December 2022

AbstractLetfn{f}_{n}be thennth Fibonacci number withf1=f2=1{f}_{1}={f}_{2}=1. Recently, the exact values of∑k=n∞1fks−1&#x230A;{\left({\sum }_{k=n}^{\infty }\frac{1}{{f}_{k}^{s}}\right)}^{-1}&#x230B;have been obtained only fors=1,2s=1,2, where⌊x⌋\lfloor x\rflooris the floor function. It has been an open problem fors≥3s\ge 3. In this article, we consider the case ofs=4s=4and show that∑k=n∞1fk4−1=fn4−fn−14+2(−1)n5f2n−1−n+25,&#x230A;{\left(\mathop{\sum }\limits_{k=n}^{\infty }\frac{1}{{f}_{k}^{4}}\right)}^{-1}&#x230B;={f}_{n}^{4}-{f}_{n-1}^{4}+\frac{2{\left(-1)}^{n}}{5}{f}_{2n-1}-\left\{\frac{n+2}{5}\right\},where{x}≔x−⌊x⌋\left\{x\right\}:= x-\lfloor x\rfloor.
Serum Galectin-3 in Hepatitis C Virus Infection Declines after Successful Virus Eradication by Direct-Acting Antiviral Therapy
Authors: Weigand Kilian , Peschel Georg , Grimm Jonathan , Müller Martina , Buechler Christa 
Published: December 2022

Background and Aims: Serum galectin-3 is regarded as an inflammatory marker in patients with chronic liver diseases. Hepatitis C virus (HCV) infection is associated with higher levels of inflammatory molecules which ameliorate by efficient treatment with direct-acting antivirals (DAAs). The aim of this study was to compare serum galectin-3 levels between HCV patients before treatment with DAAs and at the time of sustained virologic response at 12 weeks post-treatment (SVR12).
Methods: Hepatitis B and human immunodeficiency virus-negative HCV infected patients not treated with HCV therapies before were recruited at the University Hospital of Regensburg. Galectin-3 was measured by enzyme-linked immunosorbent assay in the serum of patients with chronic HCV infection, before treatment initializing, at four and twelve weeks after the start of DAA therapy and at SVR12. Associations of serum galectin-3 with C-reactive protein (CRP), leukocyte count and measures of liver disease severity were analyzed. Liver fibrosis was assessed by acoustic radiation force impulse, the aspartate aminotransferase/platelet ratio index, and the fibrosis-4 score.
Results: In the serum of 81 HCV patients, galectin-3 did not correlate with viral load, viral genotype, CRP, leukocyte count, or the model for end stage liver disease score. Therapy with DAAs effectively diminished viral load within four weeks in all patients. The median value of the serum galectin-3 was 3.0 (Q1:2.0, Q3:4.0) ng/ml before therapy and declined to 2.4 (Q1: 1.7, Q3: 3.4) ng/ml at SVR12 (p<0.001; paired samples of 67 patients). At SVR12, serum galectin-3 was not correlated with CRP (r=0.057, p=0.646) or leu-kocyte count (r=0.222, p=0.071) and did not change with increasing fibrosis stage. The associations between serum galectin-3 and body mass index, liver steatosis or diabetes could not be observed.
Conclusions: Elimination of HCV by DAA treatment lowered serum galectin-3 compared to the pre-treatment levels suggesting that HCV infection causes an increase of this immune-regulatory protein.
Adherence to Objective Therapeutic Monitoring and Outcomes in Patients with Inflammatory Bowel Disease with Adalimumab Treatment. A Real-world Prospective Study
Authors: Wetwittayakhlang Panu , Golovics Petra A , Khoury Alex Al , Ganni Elie , Hahn Gustavo Drügg , Cohen Albert , Wyse Jonathan , Bradette Marc , Bessissow Talat , Afif Waqqas , Wild Gary , Bitton Alain , Lakatos Peter Laszlo 
Published: December 2022

Background and Aims: Objective monitoring and effective early treatment using a treat-to-target approach are key to improving therapeutic outcomes in IBD patients. This study aimed to assess adherence to objective monitoring (clinical, biomarkers, and endoscopy) and its impact on clinical outcomes.
Methods: A prospective, multicenter study included consecutive IBD patients starting on adalimumab therapy between January 2019 and December 2020. Disease activity, assessed by the Harvey-Bradshaw index (HBI), partial Mayo, C-reactive protein (CRP), fecal calprotectin (FCAL), and endoscopy were evaluated at adalimumab initiation and 3, 6, 9 and 12 months. Therapeutic drug monitoring, changes in treatment, drug sustainability, and clinical outcomes were assessed.
Results: 104 IBD patients were enrolled (78.8% CD, median age 34.3 years, disease duration 9 years). During the 12 months follow-up, high adherence to clinical activity assessment was observed in both CD (81.3%- 87.7%) and UC patients (76.5-90.9%). CRP measurement decreased over time in both CD (37.3%-54.9%) and UC (29.4%-50.0%). The adherence to serial FCAL monitoring was low in CD (22.7-31.3%) and UC patients (17.6-56.0%). UC patients had higher adherence to early endoscopic assessment (<6 months) compared to CD patients (40.9% vs. 21.5%). Adherence to early combined clinical and biomarkers resulted in earlier dose optimization in CD and UC (log-rank<0.001), but drug sustainability was not different. The patients with early combined adherence had a significantly higher clinical remission rate at 1 year compared to non-adherence (70.2% vs. 29.8%, p=0.007) but no significant difference in UC patients.
Conclusions: The adherence to early objective monitoring with combined clinical and biomarkers assessment in IBD patients starting adalimumab therapy led to dose optimization and improved 1-year clinical remission in CD but did not change drug sustainability and clinical remission in UC.