bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sediment routing systems to the Atlantic rifted margin of the Guiana Shield
Authors: Rouby Delphine , Loparev Artiom , Chardon Dominique , Bajolet Flora , Dall’Asta Massimo , Paquet Fabien , Fillon Charlotte , Roig Jean-Yves , Ye Jing 
Published: April 2023

AbstractSediment routing systems of cratonic domains have not been studied extensively because their relief and erosion rates are very low, although their vast dimensions allowed them to contribute to a significant proportion of the sediments exported to the global ocean. To gain further insights into the behavior of cratonic sediment routing systems at geological time scales, we investigated the Guiana Shield and its Atlantic rifted margin (i.e., the Guiana-Suriname and Foz do Amazonas Basins, northern South America) over the Meso-Cenozoic with an emphasis on paleoenvironment and accumulation histories of the offshore sediments.We show that the basins of the Guiana Shield rifted margin record (1) periods of very low siliciclastic supply concomitant with the development of carbonate platforms, alternating with (2) phases of higher siliciclastic supply associated with sand-dominated clastic deposits and turbidites. Low siliciclastic supplies reflect either very limited rift-related relief growth and erosion such as during the Central Atlantic rifting in the Late Jurassic or intense lateritic weathering of the cratonic source area during Paleogene–Miocene climate optima. Higher siliciclastic supplies correspond either to (1) periods of rapid rift-related relief growth and erosion such as during the Equatorial Atlantic rifting (Early Cretaceous), (2) periods of drainage reorganization over a steadily eroding cratonic domain (Late Cretaceous), or (3) periods of tapping of sediments stored in the Andean retro-foreland basins via the presentday Orinoco and Amazon Rivers (Plio-Pleistocene).
The Rule of Necessity (iḍṭirār/ḍarūrah): Its Use and Development in Iran in the Reconciliation of the Resolution of Housing Problems with Islamic Law
Authors: Ansaripour M.A. 
Published: April 2023

Abstract
One of the very well-established rules of Islamic law is the rule of “necessity”. When there is a necessity, i.e. a pressing need, to act or to omit, it would make lawful every act that is unlawful in normal circumstances. The rule applies to different areas of Islamic law including public, criminal and civil law. It can be employed by individuals, where the necessity is private, and by the state, where the necessity is public. The rule has been employed by Parliament in legislation and by the relevant constitutional organs in ratifying certain parliamentary bills that were inconsistent with the primary rules of Islamic law. This paper deals briefly with the definition, effect, establishment and scope of “necessity” as well as the application of this rule by the Iranian authorities to deal with certain economic and social problems, in particular the housing need which was once a major problem in the country. By applying the rule of necessity, the ownership of certain lands came to an end or they were transferred to the government in order to be given to the needy. In addition, the government was allowed to accommodate the homeless in vacant residential buildings, to lease and/or sell the said places to the housing applicants and to borrow foreign loans for retrofitting the residential buildings against earthquakes.
An Energy Efficient Control Strategy for Electric Vehicle Driven by In-Wheel-Motors Based on Discrete Adaptive Sliding Mode Control
Authors: Zhang Han , Zhou Changzhi , Wang Chunyan , Zhao Wanzhong 
Published: April 2023

AbstractThis paper presents an energy-efficient control strategy for electric vehicles (EVs) driven by in-wheel-motors (IWMs) based on discrete adaptive sliding mode control (DASMC). The nonlinear vehicle model, tire model and IWM model are established at first to represent the operation mechanism of the whole system. Based on the modeling, two virtual control variables are used to represent the longitudinal and yaw control efforts to coordinate the vehicle motion control. Then DASMC method is applied to calculate the required total driving torque and yaw moment, which can improve the tracking performance as well as the system robustness. According to the vehicle nonlinear model, the additional yaw moment can be expressed as a function of longitudinal and lateral tire forces. For further control scheme development, a tire force estimator using an unscented Kalman filter is designed to estimate real-time tire forces. On these bases, energy efficient torque allocation method is developed to distribute the total driving torque and differential torque to each IWM, considering the motor energy consumption, the tire slip energy consumption, and the brake energy recovery. Simulation results of the proposed control strategy using the co-platform of Matlab/Simulink and CarSim® demonstrate that it can accomplish vehicle motion control in a coordinated and economic way.
Experimental Study on Titanium Alloy Cutting Property and Wear Mechanism with Circular-arc Milling Cutters
Authors: Chen Tao , Liu Jiaqiang , Liu Gang , Xiao Hui , Li Chunhui , Liu Xianli 
Published: April 2023

AbstractTitanium alloy has been applied in the field of aerospace manufacturing for its high specific strength and hardness. Nonetheless, these properties also cause general problems in the machining, such as processing inefficiency, serious wear, poor workpiece face quality, etc. Aiming at the above problems, this paper carried out a comparative experimental study on titanium alloy milling based on the CAMC and BEMC. The variation law of cutting force and wear morphology of the two tools were obtained, and the wear mechanism and the effect of wear on machining quality were analyzed. The conclusion is that in contrast with BEMC, under the action of cutting thickness thinning mechanism, the force of CAMC was less, and its fluctuation was more stable. The flank wear was uniform and near the cutting edge, and the wear rate was slower. In the early period, the wear mechanism of CAMC was mainly adhesion. Gradually, oxidative wear also occurred with milling. Furthermore, the surface residual height of CAMC was lower. There is no obvious peak and trough accompanied by fewer surface defects.
Barriers and enablers of pelvic floor rehabilitation behaviours in pregnant women with stress urinary incontinence: a qualitative analysis using the theoretical domains framework
Authors: Xu Ping , Jin Ying , Guo Pingping , Xu Xuefen , Wang Xiaojuan , Zhang Wei , Mao Minna , Feng Suwen 
Published: April 2023

Abstract
Background
Stress urinary incontinence during pregnancy is closely related to the occurrence of postpartum and long-term urinary incontinence. Early pelvic floor management is of great significance in promoting the recovery of pelvic floor tissues in pregnant women. However, effective management of urinary incontinence is far from achievable owing to the low adherence of pregnant women in partaking in pelvic floor rehabilitation. As a comprehensive framework for behavioural theory, the Theoretical Domain Framework allows for comprehensive identification of behavioural determinants. Using Theoretical Domain Framework, this study aimed to identify barriers and enablers of pelvic floor rehabilitation behaviours in pregnant women with stress urinary incontinence.

Methods
A descriptive, qualitative design was used in this study. Face-to-face semi-structured interviews were conducted with pregnant women with stress urinary incontinence based on the Theoretical Domain Framework. The data were analysed using a combination of inductive and deductive methods.

Results
Twenty pregnant women with stress urinary incontinence were interviewed. Seven themes were summarised and used to explain the pelvic floor rehabilitation behaviours of pregnant women with stress urinary incontinence. The seven themes were (1) individual knowledge and experience of pelvic floor management, (2) judgments about expected outcomes, (3) interactions of interpersonal situations, (4) environment, resources, and decision-making processes, (5) personal goal-setting and efforts towards behaviour change, (6) emotional influences on decision-making, and (7) personal characteristics. Besides the "Optimism" domain, 13 of the 14 Theoretical Domains Framework domains were found to influence pregnant patients' pelvic floor rehabilitation behaviours after deductive mapping of themes to the Theoretical Domains Framework. In addition, the inductive analysis generated a theme of personal characteristics that did not map to any of the Theoretical Domains Framework domains.

Conclusions
The pelvic floor rehabilitation behaviours of pregnant women with stress urinary incontinence are complex and are affected by many factors. The findings confirm the need for multiple interventions to support pelvic floor management in pregnant women with stress urinary incontinence, focusing on enhancing knowledge and skills in pelvic floor care and using appropriate behaviour change techniques (such as prompts) to provide a supportive environment.
The rare complication of vascular malformations of the limb after sclerotherapy: a report of 3 cases and brief literature review
Authors: Sun Nianzhe , Liu Rui , Cheng Gechang , Wu Panfeng , Yu Fang , Qing Liming , Zeng Lei , Pang Xiaoyang , Pan Ding , Xiao Yongbin , Khan Umar Zeb , Tang Juyu 
Published: April 2023

Abstract
Background
Vascular malformations are common but complicated types of disease in infants, with unclear causes and lack of effective prevention. The symptoms usually do not disappear and tend to progress without medical intervention. It is extremely necessary to choose correct treatment options for different types of vascular malformations. A large number of studies have confirmed that sclerotherapy has a tendency to become the first-line treatment in near future, but it is also associated with mild or severe complications. Furthermore, to our knowledge, the serious adverse event of progressive limb necrosis has not been systematically analyzed and reported in the literature.

Case presentation
Three cases (two females and one male) were presented who were all diagnosed as vascular malformations and were treated by several sessions of interventional sclerotherapy. Their previous medical records showed the use of several sclerosants in different sessions including Polidocanol and Bleomycin. The sign of limb necrosis did not occur during the first sclerotherapy, but after the second and third sessions. Furthermore, the short-term symptomatic treatment could improve the necrosis syndrome, but could not change the outcome of amputation.

Conclusion
Sclerotherapy undoubtedly tends to be the first-line treatment in near future, but the adverse reactions still remain major challenges. Awareness of progressive limb necrosis after sclerotherapy and timely management by experts in centers of experience of this complication can avoid amputation.
Insights into risk factors for urolithiasis: a mendelian randomization study
Authors: Zhu Shusheng , Fan Yanpeng , Hu Xia , Shao Mingming 
Published: April 2023

Abstract
Background
Risk factors for urolithiasis have not been identified. Here, we aimed to identify potentially causal risk factors driving the risk of urolithiasis.

Methods
Two sets of instrumental variables were used for analysis, derived from publicly available databases. Summary-level statistical data for urolithiasis were obtained from the MRC-IEU Consortium and UK biobank (Neale Lab). Mendelian randomization (MR) was conducted to identify causal risk of urolithiasis. Finally, the results of the two databases were combined and a meta-analysis was performed.

Results
In the MRC-IEU consortium, the odds of urolithiasis increased per 1-SD increase of body mass index (BMI) (OR = 1.0016, 95% CI:1.0004–1.0029, p = 0.010), triglycerides (OR = 1.0016, 95% CI:1.0003–1.0029, p = 0.017), adiponectin (OR = 1.0027, 95% CI:1.0003–1.0050, p = 0.024), and body fat percentage (OR = 1.008, 95% CI:1.0001–1.0161, p = 0.047). In addition, alcohol intake also increased the incidence of urolithiasis (OR = 1.0030, 95% CI:1.0009–1.0051, p = 0.005). In the UK biobank, the odds of urolithiasis increased per 1-SD increase of waist circumference (OR = 1.0215, 95% CI:1.0061–1.0372, p = 0.008) and body fat percentage (OR = 1.0239, 95% CI:1.0043–1.0440, p = 0.020). Surprisingly, we found that the risk of urolithiasis decreased with increasing hip circumference (OR = 0.9954, 95% CI:0.9915–0.9992, p = 0.017). In a meta-analysis of MR results, higher BMI (OR = 1.0016, 95% CI:1.0004–1.0027, p = 0.009), waist circumference (OR = 1.0073, 95% CI:1.0020–1.0126, p = 0.007), adiponectin (OR = 1.0026, 95% CI:1.0008–1.0043, p = 0.004), triglycerides (OR = 1.0015, 95% CI:1.0004–1.0026, p = 0.008) and body fat percentage (OR = 1.0104, 95% CI:1.0030–1.0178, p = 0.006) increased the risk of urolithiasis. Furthermore, alcohol intake also increased the incidence of urolithiasis (OR = 1.0033, 95% CI:1.0012–1.0053, p = 0.002).

Conclusions
Our MR study found that higher BMI, triglycerides, waist circumference, adiponectin, body fat percentage, and alcohol intake increased the risk of urolithiasis.
Cervical cancer screening utilization and associated factors among women attending antenatal care at Asella Referral and Teaching Hospital, Arsi zone, South Central Ethiopia
Authors: Shero Abdulmenan Ahmed , Kaso Abdene Weya , Tafa Mesfin , Agero Gebi , Abdeta Gizachew , Hailu Alemayehu 
Published: April 2023

Abstract
Background
Cervical cancer is a major public health problem affecting women worldwide. It is the second cause of mortality among women in Ethiopia. Early Cervical cancer screening has a tremendous impact on reducing morbidity and mortality related to cervical cancer infection. Therefore, this study aimed to assess cervical cancer screening utilization and associated factors among women attending Antenatal Care at Asella referral and teaching hospital, Arsi Zone, south-central Ethiopia.

Method
This study employed a facility-based cross-sectional study among 457 Antenatal Care mothers from December 2020 to February 2021. Data collection was performed using interviewer-administered structured questionnaires. Data were entered into EpiInfo Version 7 and transferred to SPSS V.21 for analysis. A logistic regression model was used to determine the factors associated with cervical cancer screening utilization and an adjusted odds ratio with a 95% confidence interval at p-value < 0.05 was computed to determine the level of statistical significance.

Result
The magnitude of cervical cancer screening utilization was found to be 7.2%(95% CI: 5.2, 10.6). Educational status of secondary and above (AOR = 2.92; 95%CI = 1.078–7.94), getting screened for any reproductive healthcare services(AOR = 4.95; 95%CI = 2.24–10.94), having multiple sexual partners(AOR = 4.55; 95%CI = 1.83–11.35), and satisfactory knowledge of cervical cancer screening(AOR = 3.89; 95%CI = 1.74–8.56) were significantly associated factors with cervical cancer screening utilization.

Conclusion
Utilization of cervical cancer screening was low among women attending Antenatal care at Asella Referral and Teaching hospital, Southcentral Ethiopia. Educational status, history of multiple sexual partners, getting screened for any reproductive healthcare services, and knowledge of cervical cancer screening were significant factors associated with the utilization of cervical cancer screening. Hence, to improve the utilization of Cervical cancer screening, there should be the implementation of programmed health education and awareness creation on the benefits of screening as well as the promotion of reproductive healthcare services at health facilities.
Gut taste receptor type 1 member 3 is an intrinsic regulator of Western diet-induced intestinal inflammation
Authors: Shon Woo-Jeong , Song Jae Won , Oh Seung Hoon , Lee Keon-Hee , Seong Hobin , You Hyun Ju , Seong Je Kyung , Shin Dong-Mi 
Published: April 2023

Abstract
Background
Long-term intake of a Western diet (WD), characterized by a high-fat content and sugary drinks, is hypothesized to contribute to the development of inflammatory bowel disease (IBD). Despite the identified clinical association, the molecular mechanisms by which dietary changes contribute to IBD development remain unknown. Therefore, we examined the influence of long-term intake of a WD on intestinal inflammation and the mechanisms by which WD intake affects IBD development.

Methods
Mice fed normal diet or WD for 10 weeks, and bowel inflammation was evaluated through pathohistological and infiltrated inflammatory cell assessments. To understand the role of intestinal taste receptor type 1 member 3 (TAS1R3) in WD-induced intestinal inflammation, cultured enteroendocrine cells harboring TAS1R3, subjected to RNA interference or antagonist treatment, and Tas1r3-deficient mice were used. RNA-sequencing, flow cytometry, 16S metagenomic sequencing, and bioinformatics analyses were performed to examine the involved mechanisms. To demonstrate their clinical relevance, intestinal biopsies from patients with IBD and mice with dextran sulfate sodium-induced colitis were analyzed.

Results
Our study revealed for the first time that intestinal TAS1R3 is a critical mediator of WD-induced intestinal inflammation. WD-fed mice showed marked TAS1R3 overexpression with hallmarks of serious bowel inflammation. Conversely, mice lacking TAS1R3 failed to exhibit inflammatory responses to WD. Mechanistically, intestinal transcriptome analysis revealed that Tas1r3 deficiency suppressed mTOR signaling, significantly increasing the expression of PPARγ (a major mucosal defense enhancer) and upregulating the expression of PPARγ target-gene (tight junction protein and antimicrobial peptide). The gut microbiota of Tas1r3-deficient mice showed expansion of butyrate-producing Clostridia. Moreover, an increased expression of host PPARγ-signaling pathway proteins was positively correlated with butyrate-producing microbes, suggesting that intestinal TAS1R3 regulates the relationship between host metabolism and gut microflora in response to dietary factors. In cultured intestinal cells, regulation of the TAS1R3–mTOR–PPARγ axis was critical for triggering an inflammatory response via proinflammatory cytokine production and secretion. Abnormal regulation of the axis was observed in patients with IBD.

Conclusions
Our findings suggest that the TAS1R3–mTOR–PPARγ axis in the gut links Western diet consumption with intestinal inflammation and is a potential therapeutic target for IBD.
Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors
Authors: Chen Siyu , Su Yuan , Zhang Manjin , Zhang Yulin , Xiu Peiming , Luo Wei , Zhang Qiuxia , Zhang Xinlu , Liang Hongbin , Lee Alex Pui-Wai , Shao Longquan , Xiu Jiancheng 
Published: April 2023

AbstractAtherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis. Researchers have been working to design multifunctional nanomedicines with the ability to target, diagnose, and treat atherosclerosis, but recent studies have also identified that nanomaterials can cause atherosclerosis. Therefore, this review aims to outline the molecular mechanisms and physicochemical properties of nanomaterials that promote atherosclerosis. By analyzing the toxicological effects of nanomaterials on cells involved in the pathogenesis of atherosclerosis such as vascular endothelial cells, vascular smooth muscle cells and immune cells, we aim to provide new perspectives for the prevention and treatment of atherosclerosis, and raise awareness of nanotoxicology to advance the clinical translation and sustainable development of nanomaterials.Graphical Abstract
Controlled-release hydromorphone and risk of infection in adults: a systematic review
Authors: Tricco Andrea C. , Parker Amanda , Hezam Areej , Nincic Vera , Yazdi Fatemeh , Lai Yonda , Harris Charmalee , Bouck Zachary , Bayoumi Ahmed M. , Straus Sharon E. 
Published: April 2023

Abstract
Background
Preliminary evidence suggests that people who inject drugs (PWID) may be at an increased risk of developing infective endocarditis (IE), hepatitis C virus (HCV) infection, and/or human immunodeficiency virus (HIV) infection from hydromorphone controlled-release formulation. The hypothesized mechanism is related to insolubility of the drug, which promotes reuse, leading to contamination of injecting equipment. However, this relationship has not been confirmed. We aimed to conduct a systematic review including adult PWID exposed to controlled-release hydromorphone and the risk of acquiring IE, HCV, and HIV.

Methods
We searched MEDLINE, EMBASE, and Evidence Based Medicine reviews from inception until September 2021. Following pilot testing, two reviewers conducted all screening of citations and full-text articles, as well as abstracted data, and appraised risk of bias using the Newcastle–Ottawa scale and Effective Practice and Organization of Care tool. Equity issues were examined using the PROGRESS-PLUS framework. Discrepancies were resolved consistently by a third reviewer. Meta-analysis was not feasible due to heterogeneity across the studies.

Results
After screening 3,231 citations from electronic databases, 722 citations from unpublished sources/reference scanning, and 626 full-text articles, five studies were included. Five were cohort studies, and one was a case–control study. The risk of bias varied across the studies. Two studies reported on gender, as well as other PROGRESS-PLUS criteria (race, housing, and employment). Three studies focused specifically on the controlled-release formulation of hydromorphone, whereas two studies focused on all formulations of hydromorphone. One retrospective cohort study found an association between controlled-release hydromorphone and IE, whereas a case–control study found no evidence of an association. One retrospective cohort study found an association between the number of hydromorphone controlled-release prescriptions and prevalence of HCV. None of the studies specifically reported on associations with HIV.

Discussion
Very few studies have examined the risk of IE, HCV, and HIV infection after exposure to controlled-release hydromorphone. Very low-quality and scant evidence suggests uncertainty around the risks of blood-borne infections, such as HCV and IE to PWID using this medication.