bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a home-based cognitive test for cognitive monitoring in subjective cognitive decline with high risk of Alzheimer’s disease
Authors: Hong Yun Jeong , Lee Si Baek , Kim Seong Hoon , Lee Myung Ah , Park Jeong Wook , Yang Dong Won 
Published: March 2023

Background and purpose:
Subjective cognitive decline (SCD) indicates a self-perceived persistent cognitive worsening despite of normal performance in standard neuropsychological tests. Owing to its heterogeneity and potential risk of Alzheimer’s disease, baseline biomarkers to predict cognitive decline are important. In the present study, we developed a home-based cognitive test (HCT) to monitor cognitive changes regularly without visiting hospitals. This study aims to compare cognitive and biomarker trajectories during a 48-month period between amyloid positive SCD and amyloid negative SCD subjects.

Methods:
Data will be collected from a prospective observational cohort study conducted in South Korea. Eighty participants with SCD aged ≥ 60 years are eligible for the study. All participants undergo annual neuropsychological tests and neurological examinations, bi-annual brain MRI scans and plasma amyloid markers, and baseline florbetaben Positron Emission Tomography scans. The amyloid burden and regional volumes will be measured. Cognitive and biomarker changes will be compared between the amyloid-positive SCD and amyloid negative SCD groups. Validation would be performed to assess reliability and feasibility of HCT.

Conclusions:
This study would suggest a perspective on SCD in terms of cognitive and biomarker trajectories. Baseline characteristics and biomarker status might affect faster cognitive decline and future biomarker trajectories. In addition, HCT could be an alternative option of in-person neuropsychological tests to track cognitive changes without visiting hospitals.
Reliability and validity of visual analysis of [18F]FE-PE2I PET/CT in early Parkinsonian disease
Authors: af Bjerkén Sara , Axelsson Jan , Larsson Anne , Flygare Carolina , Remes Jussi , Strandberg Sara , Eriksson Linda , Bäckström David , Jakobson Mo Susanna 
Published: March 2023

Objective
[18F]FE-PE2I (FE-PE2I) is a new radiotracer for dopamine transporter (DAT) imaging with PET. The aim of this study was to evaluate the visual interpretation of FE-PE2I images for the diagnosis of idiopathic Parkinsonian syndrome (IPS). The inter-rater variability, sensitivity, specificity, and diagnostic accuracy for visual interpretation of striatal FE-PE2I compared to [123I]FP-CIT (FP-CIT) single-photon emission computed tomography (SPECT) was evaluated.

Methods
Thirty patients with newly onset parkinsonism and 32 healthy controls with both an FE-PE2I and FP-CIT were included in the study. Four patients had normal DAT imaging, of which three did not fulfil the IPS criteria at the clinical reassessment after 2 years. Six raters evaluated the DAT images blinded to the clinical diagnosis, interpreting the image as being ‘normal’ or ‘pathological’, and assessed the degree of DAT-reduction in the caudate and putamen. The inter-rater agreement was assessed with intra-class correlation and Cronbach’s
α
. For calculation of sensitivity and specificity, DAT images were defined as correctly classified if categorized as normal or pathological by ≥4/6 raters.

Results
The overall agreement in visual evaluation of the FE-PE2I- and FP-CIT images was high for the IPS patients (
α
= 0.960 and 0.898, respectively), but lower in healthy controls (FE-PE2I:
α
= 0.693, FP-CIT:
α
= 0.657). Visual interpretation gave high sensitivity (both 0.96) but lower specificity (FE-PE2I: 0.86, FP-CIT: 0.63) with an accuracy of 90% for FE-PE2I and 77% for FP-CIT.

Conclusion
Visual evaluation of FE-PE2I PET imaging demonstrates high reliability and diagnostic accuracy for IPS.
Cumulative group metrics: a new and efficient method to measure the scientific impact of research groups
Authors: Moll Uta , Camp Christopher L. , Bedi Asheesh , Khoury Anthony N. , Villinger Sarah M. , Higgins Laurence D. , Wijdicks Coen A. 
Published: March 2023

Background:
Various metrics have emerged for assessing scientific impact, most of which are based on complex calculations and, in many cases, are not freely available. Moreover, most of these metrics are not intended for assessing the scientific impact of research groups. Cumulative group metrics are proposed as an efficient and cost-effective strategy for measuring group scientific impact.

Materials and methods:
The authors collected peer-reviewed output in 2020 from two academic orthopedic surgery departments [University of Michigan (UM) and Mayo Clinic Rochester (MC)] and one medical device research department [Arthrex Inc. (AI)]. The sites evaluated the Cumulative Group Number of Publications (CGNP), Cumulative Journal Impact Factor (CJIF), Cumulative CiteScore (CCS), Cumulative SCImago Journal Rank (CSJR), and Cumulative Source Normalized Impact per Paper (CSNIP) for the three institutions.

Results:
In 2020, UM published 159 peer-reviewed studies, MC published 347 peer-reviewed studies, and AI supported 141 publications. The UM publications achieved a CJIF of 513, a CCS of 891, a CSJR of 255, and a CSNIP of 247. The MC publications achieved a CJIF of 956, a CCS of 1568, a CSJR of 485, and a CSNIP of 508. AI-supported publications achieved a CJIF of 314, a CCS of 598, a CSJR of 189, and a CSNIP of 189.

Conclusion:
The presented cumulative group metrics are an effective tool to assess the scientific impact of a research group. The cumulative submetrics can further evaluate research groups compared with other departments due to field normalization. Department leadership and funding agencies can utilize these metrics to evaluate research output quantitatively and qualitatively.
Rare manifestations of alobar holoprosencephaly and the potential causes: a report of two cases
Authors: Nakawa Wael , Alkhalil Sandy , Martini Nafiza , Alawad Ieman 
Published: March 2023

Background:
Holoprosencephaly is a rare and possibly fatal neural tube defect represented by complete or partial forebrain noncleavage. It can be classified into four types: alobar, semilobar, lobar, and middle interhemispheric fusion variant. It is usually diagnosed through prenatal ultrasound or after birth by visually observing the morphological abnormalities and/or through neurological screening. Potential causes include maternal diabetes, alcoholism, infections during pregnancy, drugs, and genetic causes.

Case presentation:
Herein, we report two cases of holoprosencephaly’s rarest manifestations, albeit cebocephaly in the first case, and cyclopia with a probocis in the second. Cebocephaly, (hypotelorism with a single nostril and a blind-ended nose) was present in the first case; a Syrian newborn girl for a 41-year-old mother who works in collecting Capparis spinosa, and cyclopia with skull vault absence and posterior encephalocele in the second case; a Syrian newborn girl for a 26-year-old mother, the parents here where second-degree relatives.

Conclusions:
Early diagnosis through ultrasound is preferred in such cases and management options should be assessed and discussed with the parents due to poor prognosis. Adherence to pregnancy follow-up programs is essential to detect malformations and disorders as early as possible, especially when risk factors exist. Also, this paper may suggest a potential correlation between C. spinosa and holoprosencephaly. Therefore, we suggest that more research should be done.
Chronic myelomonocytic leukemia in a 72-year-old male from Nepal: A case report
Authors: Gurung Shekhar , Karki Saurab , Khadka Manoj , Bhatta Bhuwan , Adhikari Ayush , Shrestha Amar N. 
Published: March 2023

Introduction:
Chronic myelomonocytic leukemia (CMML) is a rare disease of clonal hematopoietic stem cells with an inherent risk of leukemic transformation, seen in an elderly male.

Case Presentation:
Herein, the authors report a case of CMML in a 72-year-old male who presented with fever and abdominal pain for 2 days with a history of easy fatigability. Examination revealed pallor and palpable supraclavicular nodes. Investigations showed leukocytosis with a monocyte count of 22% of white blood cell count, 17% blast cells in bone marrow aspiration, increased blast/promonocytes, and positive markers in immunophenotyping. The patient is planned for injection of azacitidine, 7 days cycle for a total of six cycles.

Clinical Discussion:
CMML is classified as overlapping myelodysplastic/myeloproliferative neoplasms. It can be diagnosed based on a peripheral blood smear, bone marrow aspiration and biopsy, chromosomal analysis, and genetic tests. The commonly used treatment options are hypomethylating agents like azacitidine and decitabine, allogeneic hematopoietic stem cell transplant, and cytoreductive agents like hydroxyurea.

Conclusion:
Despite various treatment options, the treatment is still unsatisfactory, demanding standard management strategies.
Congenital unilateral absence of right pulmonary artery with VSD and wide aortopulmonary window in an adult patient: a case report
Authors: Mehta Kshitij , Mehta Kajol , Bhattarai Vikash , Mahat Sandeep , Sharma Suraj , Timalsena Birat K. , Neupane Nirmal P. 
Published: March 2023

Introduction and background:
Unilateral absence of pulmonary artery (UAPA) is a very rare condition, with an estimated prevalence of 1 in 200,000 population, which is commonly associated with various cardiovascular anomalies or can occur in an isolated manner. Isolated cases survive to adulthood and remain asymptomatic, but they may frequently experience hemoptysis, repeated infections, or symptoms like dyspnea and chest pain. Due to the rarity of the disorder and its ambiguous appearance, diagnosis can be very challenging.

Case presentation:
We present a case of a 28-year-old male who visited our center with the diagnosis of ventricular septal defect with Eisenmenger syndrome elsewhere for further evaluation and was found to have right-sided UAPA with ipsilateral pulmonary hypoplasia and some associated cardiac anomalies.

Clinical discussion:
Discussions are held regarding typical chest radiograph findings, diagnostic methods, and possible therapies.

Conclusion:
Physicians should be aware of UAPA, which might go undiagnosed for several years despite regular medical care and can show up later in life, causing chronic respiratory symptoms along with Eisenmenger syndrome and ventricular septal defect like in our case.
Obesity and incidence of colorectal polyps: a case-controlled study
Authors: Salimian Sina , Habibi Maryam , Sehat Mojtaba , Hajian Abbas 
Published: March 2023

Background:
Previous essays have presented possible concordance between obesity and colorectal polyp development. However, neither for the hypothesis nor for the details general consensus exists. This study aimed to evaluate the association between higher BMI rather than the normal and colorectal polyp presentation and characteristics if any.

Methods:
Eligible patients based on study criteria who were candidates for total colonoscopy examination enrolled in this case-controlled trial. Controls had normal colonoscopy reports. A positive colonoscopy for any kind of polyp was followed by a histopathological study. Demographic data also was registered, and patients were categorized according to the calculated BMI. Groups were matched by both gender and status of tobacco abuse. Finally, the outcomes of colonoscopy and histopathological studies were compared between groups.

Results:
A total of 141 and 125 persons investigated, respectively, as patients and controls. Possible effects of gender, tobacco abuse, and cigarette smoking were declined by participants matching. Hence, we found no significant difference between groups regarding the latter variables (P>0.05). Colorectal polyps were found absolutely more in BMI>25 kg/m−2 rather than in lesser values (P<0.001). However, there was no obvious difference in the incidence of colorectal polyps between groups categorized as overweight and obese (P>0.05). Namely, even weighing over could be the risk for colorectal polyp development. Additionally, it was more expected to find neoplastic adenomatous polyp(s) with high-graded dysplasia in BMI>25 kg/m−2 (P<0.001).

Conclusion:
Even little changes in BMI further than the normal values can independently increase the risk of developing dysplastic adenomatous colorectal polyp(s) significantly.
An evaluation of the impact of anti-rabies programs in Nigeria
Authors: Adesola Ridwan O. , Akinniyi Hafeez T. , Lucero-Prisno Don E. 
Published: March 2023

Background:
Rabies remains a significant public health problem in Africa with outbreaks reported in most countries. In Nigeria, the most populous country in Africa, rabies causes a significant public health burden partly due to uncoordinated efforts and the ineffectiveness of available anti-rabies programs. We aim to address the current efforts, and challenges associated with the available anti-rabies programs in Nigeria and provide recommendations to tackle these challenges.

Results:
The anti-rabies programs available in Nigeria are highlighted. They are sponsored by different bodies such as government parastatals, veterinary teaching hospitals, professional associations, nongovernmental associations, and students. These programs provide support to eradicate rabies but are not devoid of challenges. Recommendations are provided to the Nigerian government, bodies anchoring the anti-rabies programs, and health professionals to tackle the challenges hindering the effective impact of the programs.

Conclusion:
Anti-rabies programs in Nigeria are supported by individual and collaborative bodies. It is pertinent to hold on to these programs and create a comprehensive national program to achieve effective rabies eradication in Nigeria.
Implementation and Evaluation of a Training Curriculum for Experienced Nurses in Care Coordination
Authors: Kelley Lynette , Broadfoot Kirsten , McCreight Marina , Wills Ashlea , Leonard Chelsea , Connelly Brigid , Gilmartin Heather , Burke Robert E. 
Published: March 2023

Background:
High-quality transitional care at discharge is essential for improved patient outcomes. Registered nurses (RNs) play integral roles in transitions; however, few receive structured training.

Purpose:
We sought to create, implement, and evaluate an evidence-informed nursing transitional care coordination curriculum, the Transitions Nurse Training Program (TNTP).

Methods:
We conceptualized the curriculum using adult learning theory and evaluated with the New World Kirkpatrick Model. Self-reported engagement, satisfaction, acquired knowledge, and confidence were assessed using surveys. Clinical and communication skills were evaluated by standardized patient assessment and behavior sustainment via observation 6 to 9 months posttraining.

Results:
RNs reported high degrees of engagement, satisfaction, knowledge, and confidence and achieved a mean score of 92% on clinical and communication skills. Posttraining observation revealed skill sustainment (mean score 98%).

Conclusions:
Results suggest TNTP is effective for creating engagement, satisfaction, acquired and sustained knowledge, and confidence for RNs trained in transitional care.
Associations of living in residential care facilities with participation in physical activities among older adults in the United States
Authors: Zhou Weijiao , Larson Janet L. 
Published: March 2023

Abstract

Background:
Physical activity (PA) is important for the healthy aging period, and existing research indicates that older adults in residential care facilities (RCFs) are less physically active compared with community-dwelling, but sociodemographic and health-related characteristics were not controlled. Lower PA levels might be due to older age and worse health conditions of the RCFs residents.

Objective:
This study examined the association between residential status (RCF vs. community-dwelling) and participation in PA, in a sample of 4009 older adults (65 and above) in the National Health and Aging Trends Study (NHATS), adjusting for sociodemographic and health-related characteristics.

Methods:
The current study used Rounds 8 and 9 of the NHATS which was collected in 2018 and 2019. We conducted design-based logistic regression analyses to determine whether residential care status was significantly associated with participation in walking exercises and vigorous activities, and controlled for sociodemographic and health-related characteristics.

Results:
Using multivariable logistic regression models, older adults in RCFs (n=214) were more likely to participate in walking exercises (adjusted odds ratios=1.94, P<0.01) and equally likely to participate in vigorous activities (adjusted odds ratios=1.04, P=0.84) than community-dwelling (n=3795).

Conclusions:
Our finding adds new evidence to the conventional thinking about the potential effect of RCFs on PA. Further research is needed to address the underlying mechanisms.
Interocular Contrast Balancing Partially Improves Stereoacuity in Keratoconus
Authors: Marella Bhagya Lakshmi , Vaddavalli Pravin Krishna , Reddy Jagadesh C. , Conway Miriam L. , Suttle Catherine M. , Bharadwaj Shrikant R. 
Published: March 2023

ABSTRACT

Significance
Partial improvement in stereoacuity may be achieved by balancing the contrast input to the two eyes of patients with bilaterally asymmetric keratoconus.

Purpose
Interocular differences in image quality, characterized by dissimilar contrast loss and phase shifts, is implicated in stereoacuity loss in keratoconus. This study determined whether contrast balancing improves stereoacuity in this disease condition, and, if so, whether it is dependent on the baseline interocular contrast imbalance.

Methods
Interocular contrast imbalance and stereoacuity of 43 subjects (16-33 years) with bilaterally asymmetric keratoconus were tested with spectacle correction as baseline using a binocular rivalry paradigm and random-dot stereograms, respectively. Stereoacuity measurements were repeated in a subset of 33 subjects at their contrast balance point (i.e., contrast level in stronger eye allowing balanced rivalry with 100% contrast in weaker eye) and with contrast levels biased in favor of stronger or weaker eye, all conditions in randomized order.

Results
Contrast imbalance level was significantly correlated with the subject’s stereoacuity at baseline (r = -0.47, P = .002). The median (25th-75th IQR) stereoacuity improved by 34.6% (19.0-65.1%) from baseline [748.8 arc sec (261.3-1257.3 arc sec)] to the contrast balanced condition [419.0 arc sec (86.6-868.9 arc sec)] (P < .001), independent of their baseline stereoacuity or contrast imbalance levels (r < 0.2, P > .26 for both). Contrast bias in favor of weaker eye [881.3 arc sec (239.6 to 1707.6 arc sec)] worsened stereoacuity more than a bias towards stronger eye [502.6 arc sec (181.9 to 1161.4 arc sec)], both relative to the contrast balanced condition (P < .002).

Conclusions
Interocular contrast balancing partially improves stereoacuity in bilaterally asymmetric keratoconus, independent of their baseline contrast imbalance level. Cyclopean viewing may be inherently biased towards the input from the stronger eye in keratoconus.
Factors associated with persistent postsurgical pain after total knee or hip joint replacement: a systematic review and meta-analysis
Authors: Ghoshal Arunangshu , Bhanvadia Shivam , Singh Som , Yaeger Lauren , Haroutounian Simon 
Published: March 2023

Abstract
Studies have identified demographic, clinical, psychosocial, and perioperative variables associated with persistent pain after a variety of surgeries. This study aimed to perform a systematic review and meta-analysis of factors associated with persistent pain after total knee replacement (TKR) and total hip replacement (THR) surgeries. To meet the inclusion criteria, studies were required to assess variables before or at the time of surgery, include a persistent postsurgical pain (PPSP) outcome measure at least 2 months after a TKR or THR surgery, and include a statistical analysis of the effect of the risk factor(s) on the outcome measure. Outcomes from studies implementing univariate and multivariable statistical models were analyzed separately. Where possible, data from univariate analyses on the same factors were combined in a meta-analysis. Eighty-one studies involving 171,354 patients were included in the review. Because of the heterogeneity of assessment methods, only 44% of the studies allowed meaningful meta-analysis. In meta-analyses, state anxiety (but not trait anxiety) scores and higher depression scores on the Beck Depression Inventory were associated with an increased risk of PPSP after TKR. In the qualitative summary of multivariable analyses, higher preoperative pain scores were associated with PPSP after TKR or THR. This review systematically assessed factors associated with an increased risk of PPSP after TKR and THR and highlights current knowledge gaps that can be addressed by future research.
Diagnostic Yield of Transabdominal Ultrasound-Guided Core Needle Method in Biopsies of Pancreatic Lesions
Authors: Turgut Bekir , Bakdik Süleyman , Öncü Fatih , Küçükosmanoğlu İlknur , Eren Karanis Meryem İlkay , Kerimoğlu Ramazan Saygin , Saraçoğlu Mustafa 
Published: March 2023

AbstractIn this study, it was aimed to contribute to the selection of the method to perform pancreatic lesion biopsies.Data of patients, who had undergone a percutaneous biopsy because of pancreatic masses in our institution in the period between January 2015 and November 2019, were evaluated retrospectively. The percutaneous biopsy method, the type of needle used in the procedure, and periprocedural complications were listed. Pathology and cytology reports in the archive were reviewed, and biopsy results were divided into 3 groups as benign, malignant, and inadequate. Of 308 patients included in the study, the diagnostic accuracy was verified in 124 patients through the assessment of surgical outcomes, results of biopsies from metastatic lesions, or follow-up findings. The verified results were classified as true-positives and true-negatives.Of a total of 308 patients included in the study, 23 underwent a fine-needle aspiration biopsy (FNAB) and 285 underwent a core needle biopsy (CNB). No statistical differences were observed in sample acquisition success and complications between the groups.Of the lesions with a confirmed pathological diagnosis, 67.74% were malignant and 32.26% were benign. The diagnosis was correct in 107 of 112 CNB patients (95.54%) and 9 of 12 FNAB patients (75.00%). When the success of the 2 methods was compared, it was found that outcomes of CNB were statistically more successful compared with those of FNAB.A transabdominal ultrasound-guided percutaneous CNB is a safe method with a high diagnostic yield to perform a biopsy of the pancreas.