bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship between Severity of Periodontitis and Atherosclerotic Cardiovascular Status in Patients with Acute Myocardial Infarctions: A Prospective Observational Study
Authors: Arai Riku , Fujiwara Yuusuke , Nakajima Yuki , Takahashi Kurara , Mizobuchi Saki , Migita Shohei , Miyagawa Masatsugu , Tanaka Yudai , Koyama Yutaka , Fujito Hidesato , Fukumoto Katsunori , Takei Norio , Kojima Keisuke , Murata Nobuhiro , Iida Korehito , Kitano Daisuke , Fukamachi Daisuke , Kitano Hisataka , Okumura Yasuo 
Published: January 2023

Abstract
Although the association between periodontitis (PD) and acute myocardial infarctions (AMIs) is known, it is unclear whether the severity of the PD is associated with the atherosclerotic cardiovascular status (ASCVS) degree in patients with AMIs. We prospectively investigated 50 patients with AMIs admitted to the Nihon University Itabashi Hospital from July 2019 to May 2022. All patients were classified according to the presence and severity of the PD. The periodontal status was defined by radiographic bone loss in accordance with previous studies (healthy; ≥80% remaining bone [RB], mild-moderate PD; 66 ≤ RB < 80%, and severe PD; RB < 66%), and the degree of the ASCVS was compared. The low-density lipoprotein/high-density lipoprotein ratio significantly increased from healthy to mild-moderate PD to severe PD. The SYNTAX score was numerically higher according to the severity of the PD. The carotid intima-media thickness (cIMT) (p = 0.025) and E/e’ value (p = 0.009) were highest in the severe PD group. The cIMT and E/e’ had a significant negative correlation with the PD (Person’s correlation coefficients; r=-0.296, p = 0.037, and r=-0.411, p = 0.003, respectively). We found that the severity of the PD was associated with carotid atherosclerosis and cardiac diastolic dysfunction in AMI patients, suggesting the importance of scrutinizing PD in AMI practice.
Factors affecting upper limb function recovery after mastectomy with immediate breast reconstruction: a STROBE study
Authors: Kim Asall , Beom Jaewon , Yang Eun Joo , Choi Woochol Joseph , Ji Myungki , Yi Chunghwi 
Published: January 2023

Abstract
Purpose
With improvements in surgical techniques, the number of immediate breast reconstructions (IBRs) after mastectomy is increasing. Based on reports regarding postoperative shoulder function, scapular alignment and strength recovery have been confirmed, while movement accuracy has deteriorated. As this might induce residual shoulder discomfort, proper rehabilitation may manage the situation. Along with the recommendation for early rehabilitation after breast cancer surgery, this study was designed to identify the relationship between shoulder function and acute postoperative breast cancer survivors (BrCS) after IBR.
Methods
In this prospective observational study, subjective and objective functions of 67 BrCS were observed over 4 months. Hierarchical regression and correlation studies were conducted to reveal the relationship between functional improvement.
Results
The improvement of the QuickDASH score was significantly explained by the improvement of six shoulder functions after adjusting for covariates (R2 = 0.21, p = 0.01). Among the variables, the change in range of motion and neuropathic pain was statistically significant (p < 0.03). The BrCS with chemotherapy group showed deterioration of subjective shoulder function, compared with the BrCS without chemotherapy group (t = 2.97, p = 0.004). This might be owing to the difference in neuropathic pain score changes between the two groups. There was no major difference in functional improvement between the two IBR options.
Conclusion
Regular exercise focused on pectoral tightness may be effective in improving general shoulder flexibility. Given that neuropathic pain did not change, specific interventions may be required. In addition, rehabilitation should be differentiated based on the chemotherapy plan.
Green Synthesis of GO-MgO Nanocomposite using papaya leaf extract and Its utilization in removing Cr(VI) ions from aqueous media
Authors: Girish Krishna , J Sosamony K 
Published: January 2023

Abstract
Green synthesis of nanoparticles is an emerging research topic in green nanotechnology because it is nontoxic, environmentally friendly, and less expensive than physical and chemical approaches for nanomaterial production. Graphene oxide has been proved to be a viable adsorbent material to remove heavy metals due to its large surface area and many oxygen-containing groups. Magnesium oxide nanoparticles are biocompatible and exhibit excellent stability under harsh conditions. In this study, GO decorated MgO nanomaterial (GO-MgO) was created utilising a plant-mediated synthetic method with Carica papaya leaf extract & characterization was done with XRD, FTIR, SEM, and EDX analytical techniques. To estimate the Cr(VI) adsorption by GO-MgO, effects of adsorbent dose, pH, contact time, initial concentration, and co-existing anions were investigated. It was compared with GO, MgO and chemically synthesized GO-MgO to determine the best sorbent. Reusability of the green synthesized GO-MgO was studied. Maximum adsorption efficiency occurred at pH = 4 and a contact time of 60 minutes. Maximum adsorption capacity for green synthesised GO-MgO was 178.57 mg/g which is more than another adsorbent. Adsorption process followed the Langmuir isotherm and pseudo-second-order kinetic models. The Cr adsorbed GO-MgO can reused successfully up to 5 consecutive cycles.
ATAT1 Deficiency Enhances Microglia/Macrophage Mediated Erythrophagocytosis and Hematoma Absorption following Intracerebral Hemorrhage
Authors: Yihua Zhang , Huang Ping , Cao Min , Chen Yi , Zhao Xinhu , He Xuzhi , Xu Lunshan 
Published: January 2023

Abstract
Microglia and macrophage mediated erythrophagocytosis plays a crucial role in hematoma clearance after intracerebral hemorrhage (ICH). Dynamic cytoskeletal changes accompany phagocytosis; however, whether and how they are associated with microglia/macrophages mediated erythrophagocytosis remain unclear. In this study, we investigated the dynamics of microtubule cytoskeleton in microglia/macrophage erythrophagocytosis after ICH both in vitro and in vivo. We first assessed the function of acetylated α-tubulin (Ac α-tub), a stabilized microtubule form, in erythrophagocytosis in primary DiO GFP-labeled red blood cells (RBCs) co-cultured with microglia cell line BV2 or macrophage cell line RAW264.7. Intriguingly, the expression of Ac α-tub was significantly decreased in BV2 and RAW264.7 cells with erythrophagocytosis. Moreover, silencing ATAT1, a newly discovered α-tubulin acetyltransferase, decreased ATAT1 levels and enhanced the erythrophagocytosis by BV2 and RAW264.7 cells. Consistently, in ATAT1−/− mice, we observed increased Iba-1 and perls positive microglia/macrophage phagocytes of RBCs in peri-hematoma and reduced hematoma volume in mice with ICH. Additionally, knocking out ATAT1 alleviated neuronal apoptosis and pro-inflammatory cytokines, as well as increasing anti-inflammatory cytokines around hematoma, and ultimately improved neurological recovery of after ICH. In conclusion, ATAT1 deficiency accelerates erythrophagocytosis by microglia/macrophage and hematoma absorption after ICH. These results provided novel insights into the mechanisms of hematoma clearance and the identification of therapeutic target for treating ICH.
Case report: Recurrent arterial thrombosis in a patient with polycythemia vera
Authors: Wen Jiahao , Ren Hualiang , Zhang Wangde , Li Chunmin 
Published: January 2023

Abstract
Background
Arterial thrombosis of the lower extremities is a common emergency in vascular surgery that can easily lead to amputation due to acute limb ischemia if not managed promptly. Arterial thrombosis of lower extremities is often associated with atherosclerosis, but some rare conditions, such as polycythemia vera, can also induce thrombosis. Polycythemia vera is prone to thrombosis because of its special pathological features. In addition, the thrombus sites are common in brain blood vessels and coronary arteries. Conversely, thrombosis occurring in the lower limbs is rare.
Case presentation:
A 44-year-old man with an about 20 years history of hypertension and smoking presented to the emergency department and transferred to department of vascular surgery after low molecular weight heparin administered due to acute thrombosis of lower extremities in May 2019. Laboratory tests revealed that his hemoglobin and hematocrit levels elevated, and a diagnosis of chronic polycythemia was considered. At that time, the patient’s thrombosis was not connected to polycythemia. After discharge, the patient was advised to visit the hematology department for further diagnosis confirmation. However, the patient did not comply. In August 2019, the patient was admitted to the hospital for the second time due to arterial thromboembolism in the left lower limb. After discharge, the patient completed a bone marrow biopsy and genetic testing and was diagnosed with polycythemia vera. Unfortunately, the patient has suffered from arterial thrombosis of lower limbs in September 2019, November 2019, December 2019, and October 2022 because of the non-standard treatment.
Conclusions
It is important to determine the etiology of patients with arterial thrombosis of lower extremities especially recurrent thrombosis as well as pay attention to some rare causes that can induce thrombosis. Standard treatment is vital for patients to prevent recurrent thrombosis when there are some specific etiologies as in our present case.
Modulation of Indian Summer Monsoon Rainfall response to ENSO in the recent decades and its large-scale dynamics
Authors: Sharma Tanu , Ratna Satyaban B. , Pai D. S. 
Published: January 2023

Abstract
The El Niño-Southern Oscillation (ENSO) is one of the major drivers of prominent ocean-atmosphere coupled phenomenon over the equatorial Pacific Ocean that strongly modulates the interannual variability of Indian summer monsoon rainfall (ISMR). However, the relationship between ENSO-ISMR has gone through secular variation during different decades. This study comprises a detailed analysis of the changing relationship between the ENSO and ISMR during two recent independent 30-year periods; (i) 1961–1990 and (ii) 1991–2020, using Sea Surface Temperature (SST), rainfall and various atmospheric variables. It was observed that the negative correlation of ENSO with ISMR has significantly weakened during 1991–2020 compared to 1961–1990. It was found that the La Niña associated positive rainfall intensity over central India was reduced during 1991–2020 due to weakening of vertical wind shear as compared to 1961–1990. Similarly, the El Niño associated negative rainfall intensity was reduced over large parts of north and central India during 1991–2020 due to weaker subsidence anomaly compared to 1961–1990. However, the weakened ENSO-ISMR relation in the recent period (1991–2020) mostly contributed from the disconnection of La Niña-ISMR relationship compared to El Niño-ISMR, as seen from the large-scale dynamics including the changes in the vertical wind shear and the shift in the Walker circulation. This study highlights how the changes in the patterns and the intensity of the atmospheric as well as oceanic fields within the tropical Indo-Pacific Ocean contributed to the weakening of ENSO-ISMR relation in the recent decades.
Critically ill patients: histopathological evidence of thyroid dysfunction
Authors: Saha Dipti , Chattopadhyay Saurabh , Dutta Sayak Sovan , Roy Anup Kumar 
Published: January 2023

Abstract
Background: Critical illness is characterized by severe biphasic physical and metabolic stress as a result of systemic inflammatory response syndrome and multiple organ dysfunction syndrome, and is frequently associated with non-thyroidal illness. The purpose of this study is to better understand the cytomorphological basis of NTI by performing histopathological examinations of the thyroid gland on autopsies of patients who died from critical illness.
Methods: Histopathological examination of the thyroid gland of 58 critically ill patients was performed in our hospital. The cases included 24 cases of burn injury, 24 cases of traumatic brain injury, and 10 cases of cerebral stroke. Thyroid samples obtained during a medicolegal autopsy were preserved in 10% formol saline and stained with hematoxylin and eosin. The sections were visualized under light microscopy.
Results: Out of the 58 cases examined, 21 patients showed normal thyroid findings, and the rest of the cases had unusual thyroid findings in the histopathological study. The principal finding was the distortion of thyroid follicular architecture. Other findings include mononuclear cell infiltration, clumping of thyroglobulin, and exhaustion of thyroid follicles.
Conclusion: Critical illness produces metabolically damaging effects on the thyroid gland, which functionally corresponds to the state of low T3 syndrome. These effects worsen over time and warrant intervention through hormone replacement therapy.
Soil Fertilization and Maize-Wheat Grain Production with Alternative Sources of Nutrients
Authors: Bamberg Adilson Luís , Martinazzo Rosane , Silveira Carlos Augusto Posser , Pillon Clenio Nailto , Stumpf Lizete , Bergmann Magda , Straaten Peter van , Martins Eder de Souza 
Published: January 2023

Abstract
This study evaluated regional sources of nutrients to improve the soil fertility status and yield of maize-wheat succession in Southern Brazil. The treatments were: T1: no fertilization; T2: liming with dolomitic marble; T3: alternative liming (AL) with limestone interbedded with shale; T4: AL + 50% P - with Arad natural phosphate (P-ANP) + 50% P – triple superphosphate (P-TSP); T5: AL + 100% P-ANP; T6: AL + 100% P-ANP + 100% K-rich monzogranite; T7: AL + 100% P-ANP + 100% N from tung pressed cake (N-TPC); T8: AL + 100% P-ANP + 100% K-rich monzogranite + 100% N-TPC + 100% S; T9: AL + 100% NPK recommendation (urea, TSP and KCl). Immediate and residual effects were evaluated over 2.5 years (90, 360 and 900 d) on soil fertility and maize - wheat yield. The limestone interbedded with shale released Ca, Mg and corrected soil acidity similarly to dolomitic marble. The monzogranite increased the available K in soil, although improvements of the final product could enhance K release. The fertilization strategies used in T4, T7 and T8 presented a relative productivity index of 108, 111 and 108% when compared to T9 for maize plus wheat yield, while T3 (U$=1223) and T4 (U$=1284) resulted in higher profits (+4.2 and +9.4%, respectively) than T9 (U$=1174). The limestone interbedded with shale combined with 50% of P-ANP + 50% of P – TSP (T4) provided the best economical and technical results, highlighting the potential of selected rock powders for soil fertility correction and plant-nutrients supply.
Distribution and temporal variation of total volatile organic compounds concentrations associated with health risk in Punjab, India
Authors: Singh Bhupendra Pratap , Singh Manoj , Ulman Yashmita , Sharma Urvashi , Pradhan Rashmi , Sahoo Jagruti , Padhi Sibani 
Published: January 2023

Abstract
This study demonstrates the substantial changes in the concentration of VOCs in the urban area (Punjab) due to the lockdown effects. We analyzed the data for BTEX over the three years (January to December 2019 to 2021) with pairwise comparison and trend analysis for pre-, during, and post-pandemic periods. The results indicate a substantial reduction in the mean TVOCs concentration for all the monitoring stations was found to be 8.89 ± 1.80, 5.59 ± 1.71, and 5.57 ± 1.43 µg/m3 for before, during, and post-pandemic, respectively. The level of TVOCs declined by -43% for all monitoring stations during the lockdown period compared to the previous years. However, after the lockdown, an increase in the concentration of TVOC by 16% was observed in unlock; this may be due to the re-opening of commercial places, various industries, and transportation, as they are responsible for emissions of BTEX. This reduction indicates an overall improvement in the VOCs due to restrictions on transportation, construction, and the industrial sectors during the lockdown. Despite the overall decreasing trend of VOCs level, few monitoring stations indicate less variation due to meteorological effects. A Higher T/B ratio was found in Patiala (2.97 µg/m3) before the pandemic, which may indicate vehicle (traffic) emission sources and evaporative emission of solvent. The higher level of TVOCs was associated with mobile emission sources and industrial activities. The LCR values for benzene were found to be higher in children than in males and females, which indicated the possible risk. The LCR values for benzene exceeded the prescribed value by CPCB for children.
Co-cultures of iPSC-derived Mammary-like Organoids and Patient-derived Microtumors Model Invasive Behavior of Breast Cancer ex vivo
Authors: Keller Anna-Lena , Anderle Nicole , Schrenk Monika , Greis Deborah , Binner Anna , Visser Dmitri , Göpfert Jens , Koch André , Weiss Martin , Brucker Sara , Schenke-Layland Katja , Schmees Christian 
Published: January 2023

Abstract
Background
Tumor-adjacent benign mammary epithelium and myoepithelium can play a pivotal role in tumor growth and progression. We investigated the invasive behavior of patient-derived microtumors and breast cancer cell line-derived spheroids in co-culture with induced pluripotent stem cell-derived mammary-like organoids in an autologous and allogenic manner. This co-culture systems enables a better understanding of the tumor-promoting function of the benign mammary (myo-) epithelium in different types of breast cancers.
Methods
Using three-dimensional co-culture settings of induced pluripotent stem cell-derived mammary-like organoids and patient-derived microtumors or cancer cell line-derived spheroids, we investigated tumor growth and invasiveness of the cancers by using imaging-based analysis. Levels of Fibronectin and Metalloproteinase-2 in co-cultures and respective mono-cultures were measured using multiplexed Luminex assay.
Results
We observed significant increases in growth and invasiveness of invasive ductal carcinoma of no special type patient-derived microtumors in co-culture with induced pluripotent stem cell-derived mammary-like organoids. We identified upregulations of the prognostic markers Fibronectin and Metalloproteinase-2 in all co-cultures compared to respective mono-cultures of mammary-like organoids, patient-derived microtumors and cell line-derived spheroids.
Conclusions
These findings indicate a tumor-promoting role of the tumor-adjacent mammary (myo-) epithelium dependent on the tumor composition and tumor stage. Our results highlight the importance of breast tumor models that closely resemble the heterogenous composition of primary breast tumors.
Mechanical and Permeability Characteristics of Q 2 Soft-plastic Loess under Coupled Hydro-Mechanical Conditions
Authors: Hong Qiuyang , Lai Hongpeng , Liu Yuyang 
Published: January 2023

Abstract
For the soft-plastic loess tunnel engineering, collapse and damage of the surrounding rock during excavation are often driven by the combined action of the seepage water and the unloading effect. Under water pressure and unloading, the soil suffers complex stress-seepage coupling action causing the inevitable change of permeability and mechanical properties. In this paper, seepage control devices were added to the GDS test device, and a new triaxial permeability measurement system was developed. Triaxial unloading-seepage tests were conducted on soft-plastic loess under the effect of hydraulic coupling. The variation of permeability characteristics of Q2 soft-plastic loess under lateral unloading and the soil mechanical characteristics under different seepage pressure were analyzed. Meanwhile, microstructure characteristics of soft-plastic loess during the triaxial test were obtained by scanning electron microscope to clarify the deformation and seepage mechanism. The results show that the strength of soft-plastic loess decreases significantly with the increase of osmotic pressure. Under the condition of 50 kPa and 100 kPa osmotic pressure, the cohesive force of soft-plastic loess decreases by 15.5% and 39.0% and the friction angle decreases by 9.4% and 22.6%, respectively. The permeability coefficient of loess increases slowly at first and then increases rapidly during the unloading process. The main reason for the significant increase of permeability coefficient is the penetration of soil fissures and the formation of shear bands after entering the plastic deformation stage.
Privacy preserving COVID-19 vaccinating- and testing-pass for the European Union
Authors: Schrahe Dominik , Städter Thomas 
Published: January 2023

Abstract
Purpose
Physicians and scientists hope to gain new insights from health data to improve medical care and optimize costs in the healthcare sector. However, data protection laws in Europe often impose limits on the use of patient data. During the COVID-19 pandemic the exercise of all civil rights and liberties depends on successful vaccinations, negative tests, and recovery from the disease. Digital proof thereof was of particular importance for participation in social life. This research project aims to create a system concept for vaccination, testing, and recovery proof called P3VT (Privacy Preserving Pass for Vaccination and Testing), which makes all collected data anonymously available in real time to scientists as well as to political pandemic management.
Methods
Based on the Design Science Research methodology (DSR) [1], P3VT is the artifact created by the research project. It was developed over several iterations, consistently taking into consideration the goals of privacy-by-design, data minimisation and transparency of the EU-GDPR. Expert interviews have been conducted to validate the system from a medical, technical and data protection perspective.
Results
By using distributed ledger technology and distributed identities, P3VT offers the following advantages compared to the EU digital COVID certificate:
· Pseudonymous proof of vaccination, testing, and recovery, reducing the misuse of sensitive personal data
· Transparency on type, time, and purpose of proof increases users' trust
· Use of anonymous vaccination and testing data to improve regulatory pandemic management, as well as research
· Flexible specification of proof conditions based on the latest epidemiological findings or individual requirements
· Elimination of manual ID checks during the verification process.
Conclusion
P3VT provides a novel combination of unforgeable pseudonymous proof of COVID-19 vaccination, testing, and recovery with simultaneous provision of anonymous data for research purposes and regulatory pandemic management. It is therefore an example of how the comprehensive provision of health data for research purposes can be combined with high data protection requirements. Further areas of application are conceivable.