bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONSTRUCTION OF SEPSIS DIAGNOSTIC MODELS AND IDENTIFICATION OF MACROPHAGE SUBPOPULATIONS BASED ON PYROPTOSIS-RELATED GENES
Authors: Sun Zefang , Zhang Tao , Ning Caihong , Shen Dingcheng , Pei Wenwu , Zhou Rui , Zhu Shuai , Huang Gengwen 
Published: May 2023

ABSTRACT

Background: Numerous studies have shown that pyroptosis is associated with sepsis progression, which can lead to dysregulated host immune responses and organ dysfunction. Therefore, investigating the potential prognostic and diagnostic values of pyroptosis in patients with sepsis is essential. Methods: We conducted a study using bulk and single-cell RNA sequencing (scRNA-seq) from the Gene Expression Omnibus database to examine the role of pyroptosis in sepsis. Univariate logistic analysis, least absolute shrinkage, and selection operator regression analysis were used to identify pyroptosis-related genes (PRGs), construct a diagnostic risk score model, and evaluate the selected genes' diagnostic value. Consensus clustering analysis was used to identify the PRG-related sepsis subtypes with varying prognoses. Functional and immune infiltration analyses were used to explain the subtypes' distinct prognoses, and scRNA-seq data were used to differentiate immune-infiltrating cells and macrophage subsets and study cell-cell communication. Results: A risk model was established based on 10 key PRGs (NAIP, ELANE, GSDMB, DHX9, NLRP3, CASP8, GSDMD, CASP4, APIP, and DPP9), of which four (ELANE, DHX9, GSDMD, and CASP4) were associated with prognosis. Two subtypes with different prognoses were identified based on the key PRG expressions. Functional enrichment analysis revealed diminished nucleotide oligomerization domain–like receptor pathway activity and enhanced neutrophil extracellular trap formation in the subtype with a poor prognosis. Immune infiltration analysis suggested a different immune status between the two sepsis subtypes, with the subtype with a poor prognosis exhibiting stronger immunosuppression. The single-cell analysis identified a macrophage subpopulation characterized by gasdermin D (GSDMD) expression that may be involved in pyroptosis regulation, which was associated with the prognosis of sepsis. Conclusion: We developed and validated a risk score for sepsis identification based on 10 PRGs, four of which also have potential value in the prognosis of sepsis. We identified a subset of gasdermin D macrophages associated with poor prognosis, providing new insights into the role of pyroptosis in sepsis.
PASSIVE LEG RAISING–INDUCED CHANGES IN PEAK VELOCITY VARIATION OF LEFT VENTRICULAR OUTFLOW TRACT TO PREDICT FLUID RESPONSIVENESS IN POSTOPERATIVE CRITICALLY ILL ELDERLY PATIENTS
Authors: Wan Jing-jie , Chen Jun , Xu Li , Peng Ke , Xie Jin 
Published: May 2023

ABSTRACT

Background: Accurate prediction of fluid responsiveness is important for postoperative critically ill elderly patients. The objective of this study was to evaluate the predictive values of peak velocity variation (ΔVpeak) and passive leg raising (PLR)-induced changes in ΔVpeak (ΔVpeakPLR) of the left ventricular outflow tract to predict fluid responsiveness in postoperative critically ill elderly patients. Method: Seventy-two postoperative elderly patients with acute circulatory failure who were mechanically ventilated with sinus rhythm were enrolled in our study. Pulse pressure variation (PPV), ΔVpeak, and stroke volume were collected at baseline and after PLR. An increase of >10% in stroke volume after PLR defined fluid responsiveness. Receiver operating characteristic curves and gray zones were constructed to assess the ability of ΔVpeak and ΔVpeakPLR to predict fluid responsiveness. Results: Thirty-two patients were fluid responders. The area under the receiver operating characteristic curves (AUC) for baseline PPV and ΔVpeak to predict fluid responsiveness was 0.768 (95% confidence interval [CI], 0.653–0.859; P < 0.001) and 0.899 (95% CI, 0.805–0.958; P < 0.001) with gray zones of 7.63% to 12.66% that included 41 patients (56.9%) and 9.92% to 13.46% that included 28 patients (38.9%). ΔPPVPLR predicted fluid responsiveness with an AUC of 0.909 (95% CI, 0.818–0.964; P < 0.001), and the gray zone was 1.49% to 2.93% and included 20 patients (27.8%). ΔVpeakPLR predicted fluid responsiveness with an AUC of 0.944 (95% CI, 0.863–0.984; P < 0.001), and the gray zone was 1.48% to 2.46% and included six patients (8.3%). Conclusions: Passive leg raising–induced changes in peak velocity variation of blood flow in the left ventricular outflow tract accurately predicted fluid responsiveness with a small gray zone in postoperative critically ill elderly patients.
PREHOSPITAL PLASMA IS NONINFERIOR TO WHOLE BLOOD FOR RESTORATION OF CEREBRAL OXYGENATION IN A RHESUS MACAQUE MODEL OF TRAUMATIC SHOCK AND HEMORRHAGE
Authors: Morgan Clifford G. , Neidert Leslie E. , Ozuna Kassandra M. , Glaser Jacob J. , Pusateri Anthony E. , Tiller Michael M. , Cardin Sylvain 
Published: May 2023

ABSTRACT

Introduction: Traumatic shock and hemorrhage (TSH) is a leading cause of preventable death in military and civilian populations. Using a TSH model, we compared plasma with whole blood (WB) as prehospital interventions, evaluating restoration of cerebral tissue oxygen saturation (CrSO2), systemic hemodynamics, colloid osmotic pressure (COP) and arterial lactate, hypothesizing plasma would function in a noninferior capacity to WB, despite dilution of hemoglobin (Hgb). Methods: Ten anesthetized male rhesus macaques underwent TSH before randomization to receive a bolus of O(−) WB or AB(+) plasma at T0. At T60, injury repair and shed blood (SB) to maintain MAP > 65 mm Hg began, simulating hospital arrival. Hematologic data and vital signs were analyzed via t test and two-way repeated measures ANOVA, data presented as mean ± SD, significance = P < 0.05. Results: There were no significant group differences for shock time, SB volume, or hospital SB. At T0, MAP and CrSO2 significantly declined from baseline, though not between groups, normalizing to baseline by T10. Colloid osmotic pressure declined significantly in each group from baseline at T0 but restored by T30, despite significant differences in Hgb (WB 11.7 ± 1.5 vs. plasma 6.2 ± 0.8 g/dL). Peak lactate at T30 was significantly higher than baseline in both groups (WB 6.6 ± 4.9 vs. plasma 5.7 ± 1.6 mmol/L) declining equivalently by T60. Conclusions: Plasma restored hemodynamic support and CrSO2, in a capacity not inferior to WB, despite absence of additional Hgb supplementation. This was substantiated via return of physiologic COP levels, restoring oxygen delivery to microcirculation, demonstrating the complexity of restoring oxygenation from TSH beyond simply increasing oxygen carrying capacity.
Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites
Authors: Ressurreição Margarida , Fréville Aline , van Ooij Christiaan 
Published: May 2023

ABSTRACTMalaria parasites alter multiple properties of the host erythrocyte by exporting proteins into the host cell. Many exported proteins contain a five-amino acid motif called the Plasmodium Export Element (PEXEL) that is cleaved by the parasite protease Plasmepsin V (PM V). The presence of a PEXEL is considered a signature of protein export and has been used to identify a large number of exported proteins. The export of proteins becomes essential midway through the intraerythrocytic cycle – preventing protein export blocks parasite development 18-24 h after invasion. However, a genetic investigation revealed that the absence of the PEXEL protein PFA0210c causes parasite development to arrest immediately after invasion. We now show that this protein (renamed PV6) is cleaved by PM V but not exported into the host erythrocyte and instead functions in the parasitophorous vacuole. Furthermore, we show that the lysine residue that becomes the N terminus of PV6 after processing by PM V prevents export. This is the first example of a nativePlasmodium falciparumPM V substrate that remains in the parasitophorous vacuole. We also provide evidence that the parasite produces at least one additional essential, non-exported PM V substrate. These results reveal that the presence of a PEXEL, and hence processing of a protein by PM V, does not always target a protein for export and that PM V has a broader function in parasite growth beyond processing exported proteins. Furthermore, we utilized this finding to investigate possible requirements for protein export further.
Dynamical analysis of a rotating rigid body containing a viscous incompressible fluid
Authors: He Ji-Huan , Amer T.S. , Amer W.S. , Elkafly H.F. , Galal A.A. 
Published: May 2023

Purpose
The purpose of this paper is to study the dynamical properties of a rotating rigid body (RB) containing a viscous incompressible fluid.

Design/methodology/approach
The Reynolds number is assumed to be small so that the governing equations can be easily obtained, and the asymptotic technique is used to solve the problem.

Findings
The effects of the various body parameter values on the motion’s behavior are theoretically elucidated, which can be used for optimization of the charged RB.

Originality/value
This paper finds the missing piece of the puzzle when it comes to the rotating RB containing a viscous fluid; it clearly elucidates graphically how the body parameters affect its dynamical properties.
Stimulating innovation performance through knowledge-oriented leadership and knowledge sharing: the moderating role of market turbulence
Authors: Le Phong Ba , Do Yen Hai 
Published: May 2023

Purpose
Due to the vital role of innovation for firms to respond to the change and achieve competitive advantage, the purpose of this study is to investigate the influence of knowledge-oriented leadership (KOL) on innovation performance (IP) via the mediating role of knowledge sharing (KS). This study also clarifies the KS-IP relationship by exploring the moderating role of market turbulence.

Design/methodology/approach
Analysis of moment structures and structural equation modeling are applied to examine the relationship among the latent factors in the proposed research model using data collected from 281 participants in 112 manufacturing and service firms in Vietnam.

Findings
The findings revealed that KOL serves as a key precursor to foster IP, directly or indirectly, through knowledge-oriented leaders’ effect on tacit and explicit KS behaviors. In addition, the paper highlights the moderating role of market turbulence in strengthening the impact of KS activities on IP.

Research limitations/implications
By highlighting the important role KOL practice for stimulating KS behaviors, this paper provides a valuable understanding and novel approach for firms to improve IP. The research findings support the idea that market turbulence significantly contributes to increasing the effects of KS behaviors on IP.

Originality/value
This study contributes to bridging research gaps in the literature and advances the insights of how KOL directly and indirectly fosters IP via mediating roles of tacit and explicit KS processes under the effects of market turbulence.
Exploring the impact of ambient air quality standards on firm innovation: evidence from listed industrial companies in China
Authors: Huang Min , Li Xiaobo 
Published: May 2023

PurposeThis paper aims to identify the impact of the new ambient air quality standards (AAQS) on firm innovation.Design/methodology/approachTaking listed companies from 2009 to 2014 as the research object, the authors focus on the quasinatural experiment of the pilot policy of the new AAQS and apply the time-varying difference-in-differences (DID) method to conduct the empirical test.FindingsThe authors find that the new AAQS has a negative effect on firm innovation, and this negative impact may be caused by the increased environmental expenditures following the implementation of the new AAQS. Furthermore, the authors find that firm profitability and state ownership weaken this negative effect, but the effect of the degree of industrial pollution is statistically insignificant.Originality/valueThe study is an initial effort to explore the causal effect of the new AAQS on firm innovation. This study enriches the literature on the impact of environmental regulations on firm innovation and provides some reference value for the formulation of environmental regulation policies in developing countries.
Examination the effects of organizational innovation and knowledge management strategy in information technology companies in R&D departments on service quality and product innovation
Authors: Sonmez Cakir Fatma , Kalaycioglu Ozan , Adiguzel Zafer 
Published: May 2023

PurposeThe purpose of the article is to examine the concepts of knowledge management strategies, innovation and service quality in information technology companies that have research and development (R&D) departments in the technoparks of research universities.Design/methodology/approachThe research was carried out in information technology companies with R&D departments in the technoparks of universities. Due to the “innovation” focus of the research, 302 engineers were selected by random sampling from engineers working in information technology companies in technoparks, and the prepared scale was sent to them via e-mail. In total, 302 units of data were subjected to path analysis and mediation effect analysis using the SmartPLS program.FindingsIn the research, it is supported by hypotheses that both knowledge management strategies and organizational innovation have a positive effect on the success of service quality and product innovation in information technology companies with R&D departments. At the same time, it can be explained as a result of analysis that innovation capability has both an independent and an intermediary variable effect.Research limitations/implicationsConsidering the limitations of the research, it is not correct to generalize the results of the analysis because the research was conducted only in information technology companies located in technoparks, and the data were collected from engineers working in these companies. For this reason, it is recommended that similar studies that are planned to be conducted in the future should do their research by taking this situation into account. At the same time, it is recommended to carry out future studies in different sectors and to bring the results obtained to the literature by comparing them.Practical implicationsThe importance of information is increasing in technology-oriented companies where competition is increasing. Companies that cannot go beyond imitation or offer similar products and/or services cannot compete with their competitors in a competitive environment. The fact that companies can be successful in a competitive environment is supported by hypotheses as a result of the analysis that they need to develop organizational innovation and knowledge, as well as develop innovation capability at the same time.Originality/valueThe research is an original study in terms of examining the R&D departments of information technology companies operating in the technoparks of universities. Innovation and knowledge management strategies are examined within the scope of the research model by collecting data from information technology companies with R&D departments.
The moderating effects of strategy on the relation of working capital management with profitability
Authors: Vlismas Orestes 
Published: May 2023

Purpose
This study aims to explore the moderating effects of strategy on the relationship between working capital management (WCM) and profitability.

Design/methodology/approach
A data sample of 72,444 firm-year observations of US-listed firms during 2000–2020 was used. The research hypotheses were tested using a panel regression analysis and an appropriate research instrument that signifies a firm’s strategic positioning.

Findings
The prospecting (defending) strategy has a decreasing (increasing) moderating effect on the relationship between WCM and profitability. The empirical findings are not affected by the level of earnings management, the presence of motives to meet earnings targets or the intensity of unreported intangible assets. Additionally, the reported empirical results remain robust within the context of propensity score matching regression analysis, in the presence of nonlinear effects of WCM on profitability, when alternative measures of WCM are used, and between firms with an increase or decrease in future profitability or different levels of efficiency on net WCM investments.

Research limitations/implications
This study may stimulate future research exploring the moderating effects of various variables on the relationship between WCM and operating performance.

Practical implications
The findings highlight the importance of strategy for improving the performance evaluation of WCM policies and the prediction accuracy of the consequences of a strategy on short-term operating performance.

Originality/value
Prior empirical research has documented either a negative or positive relationship between WCM and profitability, which implies the presence of moderating effects of various factors. This study provides empirical evidence of the moderating effects of strategy on the relationship between WCM and profitability.
Examining the viability of lean production practices in the Industry 4.0 era: an empirical evidence based on B2B garment manufacturing sector
Authors: Saha Palash , Talapatra Subrata , Belal H.M. , Jackson Victoria , Mason Amanda , Durowoju Olatunde 
Published: May 2023

Purpose
This study aims to investigate the influence of the interrelationship between the deployment of Industry 4.0 (I4.0) technologies and the application of lean production (LP) practices on the degree of organizational sustainability performance (SP) enhancement of the Bangladeshi ready-made garment (RMG) sector.

Design/methodology/approach
Previously, researchers have applied the resource-based view (RBV) or dynamic capability view (DCV) to describe the interaction of resources and capacities (technologies, management practices, SP) to analyze their effectiveness. However, in light of several contemporary academic discussions, this study contends that these organizational views are inappropriate for explicating SP. Hence, as the foundation of this study’s theoretical framework, the authors used the practice-based view (PBV), which is recommended as a useful window to evaluate the function of practices that are common and simple to emulate in execution. To test the theoretical framework and research hypothesis, this study used partial least square (PLS) analysis. For that, the authors carried out a systematic survey to collect data from 80 Bangladeshi RMG factories.

Findings
The results of this research imply that LP is a crucial factor in enhancing organizational SP. Moreover, the results also indicate that the adoption of I4.0 technologies along with LP can assist in delivering the lean objectives more efficiently and, therefore, the combined application of LP practices and I4.0 technologies play a significant role in enhancing organizational SP.

Originality/value
Though the present literature indicates the probable significant association between LP and SP or I4.0 technologies and SP, no study, with the best of the authors’ knowledge, has empirically examined the combined impacts of correlation between LP and I4.0 on SP. This is also a unique study to apply the PBV theory to explain the organizational SP through the combination of common resources and technologies.
Deploying artificial intelligence for anti-money laundering and asset recovery: the dawn of a new era
Authors: Pavlidis Georgios 
Published: May 2023

PurposeThis paper aims to critically examine the digital transformation of anti-money laundering (AML) and countering the financing of terrorism (CFT) in light of the Financial Action Task Force (FATF) San Jose principles, the Organisation for Economic Co-operation and Development (OECD) principles for artificial intelligence (AI) and the proposed European Union (EU) Artificial Intelligence Act. The authors argue that AI tools can revolutionize AML/CFT and asset recovery, but there is a need to strike a balance between optimizing AML efficiency and safeguarding fundamental rights.Design/methodology/approachThis paper draws on reports, legislation, legal scholarships and other open-source data on the digital transformation of AML/CFT, particularly the deployment of AI in this context.FindingsA new regulatory framework with robust safeguards is necessary to mitigate the risks associated with the use of new technologies in the AML context.Originality/valueThis study is one of the first to examine the use of AI in the AML/CFT context in light of the FATF San Jose principles, the OECD AI principles and the proposed EU AI Act.
Development and validation of an individual entrepreneurial potential new measurement scale
Authors: Ephrem Akilimali Ndatabaye , Murimbika McEdward 
Published: May 2023

Purpose
As good as existing measurements of entrepreneurial potential (EP) may appear in the literature, they are fragmented, suffer from the lack of theory integration and clarity, are inadequately specified and assessed and the dimensions are unordered by importance. These limitations of EP metrics have hindered entrepreneurial practice and theory advancement. There is a risk of atomistic evolution of the topic among “siloed” scholars and room for repetitions without real progress. The purpose of this paper was to take stock of existing measurements from which the authors developed a new instrument that is brief and inclusive.

Design/methodology/approach
The authors followed several steps to develop and validate the new instrument, including construct domain name specification, literature review, structured interviews with entrepreneurs, face validation by experts, semantic validation and statistical validation after two waves of data collected on employee and entrepreneur samples.

Findings
A clear operational definition of EP is proposed and serves as a starting point towards a unified EP theory. The new EP instrument is made up of 34 items classified into seven dimensions, which in order of importance are proactive innovativeness, management skill, calculated risk-taking, social skill, financial literacy, entrepreneurial competencies prone to cognitive and heuristic biases and bricolage. The authors provide evidence for reliability and validity of the new instrument.

Research limitations/implications
Although a model is not the model, the authors discuss several ways in which the new measurement model can be used by different stakeholders to promote entrepreneurship.

Originality/value
The authors discuss the domain representativeness of the new scale and argue that the literature can meaningfully benefit from a non-fuzzy approach to what makes the EP of an individual. By developing a new EP instrument, the authors set an important pre-condition for advancing entrepreneurial theory and practice.