bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian disruption and sleep disorders in neurodegeneration
Authors: Shen Yun , Lv Qian-kun , Xie Wei-ye , Gong Si-yi , Zhuang Sheng , Liu Jun-yi , Mao Cheng-jie , Liu Chun-feng 
Published: February 2023

AbstractDisruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions of circadian rhythms and sleep cycles and neurodegenerative diseases. Circadian disruption and sleep disorders aggravate neurodegeneration and neurodegenerative diseases can in turn disrupt circadian rhythms and sleep. Importantly, circadian disruption and various sleep disorders can increase the risk of neurodegenerative diseases. Thus, harnessing the circadian biology findings from preclinical and translational research in neurodegenerative diseases is of importance for reducing risk of neurodegeneration and improving symptoms and quality of life of individuals with neurodegenerative disorders via approaches that normalize circadian in the context of precision medicine. In this review, we discuss the implications of circadian disruption and sleep disorders in neurodegenerative diseases by summarizing evidence from both human and animal studies, focusing on the bidirectional links of sleep and circadian rhythms with prevalent forms of neurodegeneration. These findings provide valuable insights into the pathogenesis of neurodegenerative diseases and suggest a promising role of circadian-based interventions.
The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population
Authors: Bourdeau-Julien Isabelle , Castonguay-Paradis Sophie , Rochefort Gabrielle , Perron Julie , Lamarche Benoît , Flamand Nicolas , Di Marzo Vincenzo , Veilleux Alain , Raymond Frédéric 
Published: February 2023

Abstract
Background
Bioactive lipids produced by human cells or by the gut microbiota might play an important role in health and disease. Dietary intakes are key determinants of the gut microbiota, its production of short-chain (SCFAs) and branched-chain fatty acids (BCFAs), and of the host endocannabinoidome signalling, which are all involved in metabolic diseases. This hypothesis-driven longitudinal fixed sequence nutritional study, realized in healthy participants, was designed to determine if a lead-in diet affects the host response to a short-term dietary intervention. Participants received a Mediterranean diet (MedDiet) for 3 days, a 13-day lead-in controlled diet reflecting the average Canadian dietary intake (CanDiet), and once again a MedDiet for 3 consecutive days. Fecal and blood samples were collected at the end of each dietary phase to evaluate alterations in gut microbiota composition and plasma levels of endocannabinoidome mediators, SCFAs, and BCFAs.

Results
We observed an immediate and reversible modulation of plasma endocannabinoidome mediators, BCFAs, and some SCFAs in response to both diets. BCFAs were more strongly reduced by the MedDiet when the latter was preceded by the lead-in CanDiet. The gut microbiota response was also immediate, but not all changes due to the CanDiet were reversible following a short dietary MedDiet intervention. Higher initial microbiome diversity was associated with reduced microbiota modulation after short-term dietary interventions. We also observed that BCFAs and 2-monoacylglycerols had many, but distinct, correlations with gut microbiota composition. Several taxa modulated by dietary intervention were previously associated to metabolic disorders, warranting the need to control for recent diet in observational association studies.

Conclusions
Our results indicate that lipid mediators involved in the communication between the gut microbiota and host metabolism exhibit a rapid response to dietary changes, which is also the case for some, but not all, microbiome taxa. The lead-in diet influenced the gut microbiome and BCFA, but not the endocannabinoidome, response to the MedDiet. A higher initial microbiome diversity favored the stability of the gut microbiota in response to dietary changes. This study highlights the importance of considering the previous diet in studies relating the gut microbiome with lipid signals involved in host metabolism.
Data-driven identification and classification of nonlinear aging patterns reveals the landscape of associations between DNA methylation and aging
Authors: Okada Daigo , Cheng Jian Hao , Zheng Cheng , Kumaki Tatsuro , Yamada Ryo 
Published: February 2023

AbstractBackgroundAging affects the incidence of diseases such as cancer and dementia, so the development of biomarkers for aging is an important research topic in medical science. While such biomarkers have been mainly identified based on the assumption of a linear relationship between phenotypic parameters, including molecular markers, and chronological age, numerous nonlinear changes between markers and aging have been identified. However, the overall landscape of the patterns in nonlinear changes that exist in aging is unknown.ResultWe propose a novel computational method, Data-driven Identification and Classification of Nonlinear Aging Patterns (DICNAP), that is based on functional data analysis to identify biomarkers for aging and potential patterns of change during aging in a data-driven manner. We applied the proposed method to large-scale, public DNA methylation data to explore the potential patterns of age-related changes in methylation intensity. The results showed that not only linear, but also nonlinear changes in DNA methylation patterns exist. A monotonous demethylation pattern during aging, with its rate decreasing at around age 60, was identified as the candidate stable nonlinear pattern. We also analyzed the age-related changes in methylation variability. The results showed that the variability of methylation intensity tends to increase with age at age-associated sites. The representative variability pattern is a monotonically increasing pattern that accelerates after middle age.ConclusionDICNAP was able to identify the potential patterns of the changes in the landscape of DNA methylation during aging. It contributes to an improvement in our theoretical understanding of the aging process.
A “data-driven uncertainty” computational method to model and predict instabilities of a frictional system
Authors: Maaboudallah Farouk , Atalla Noureddine 
Published: February 2023

AbstractMost of the recently developed methods for predicting instabilities of frictional systems couple stochastic algorithms with the finite element method (FEM). They use random variables to model the uncertainty of input parameters through standard probability laws. Regardless of the fact that advanced numerical schemes are available nowadays, a systematic and accurate method to describe finely the uncertainties upstream the model, and thus predict its response is still missing. In this contribution, we present a data-driven stochastic finite element scheme to predict the dynamic behavior of a rubbing system. The proposed framework relies on data-driven approach and uses four steps. In the first, the measured data are integrated directly, for the uncertainty quantification, by means of the random balance design (RBD). In the second step, the generated stochastic data are evaluated in an iterative way to solve friction-induced vibration problem. In the third step, the resulted data are reordered in such a way that the corresponding values of each measured input parameters are ranked in ascending order. Finally, the Fourier spectrum is introduced on the reordered results to compute the sensitivity indices. Thus, instead of Monte Carlo-based formalism or Fourier Amplitude Sensitivity Test (FAST), the computational cost of the proposed method is kept down to $$\mathcal {O}(N)$$

O
(
N
)

with N the number of samples. We investigate the efficiency of the suggested solver on a reduced brake system. Altogether, the suggested procedure achieves excellent accuracy at a much reduced computational time compared to the methods available in the literature.
Illness perceptions, fear of progression and health-related quality of life during acute treatment and follow-up care in paediatric cancer patients and their parents: a cross-sectional study
Authors: Herzog Kristina , Schepper Florian , Pletschko Thomas , Herrmann Jessy , Budich Mihaela , Christiansen Holger , Suttorp Meinolf , Martini Julia 
Published: February 2023

Abstract
Background
This study examines the role of illness perceptions and fear of progression (FoP) in paediatric cancer patients and their parents for patient’s health-related quality of life (HRQoL), controlling for sociodemographic and medical variables. 4–18-year-old patients in acute treatment or follow-up care and one parent were examined.

Methods
N = 46 patient-parent dyads in acute treatment and n = 84 dyads in follow-up care completed measures on illness perceptions (Illness-Perceptions-Questionnaire for 12–18-year-old patients and parents or as age-adapted puppet interview for 4–11-year-old patients) and FoP (Fear-of-Progression-Questionnaire for 7–18-year-old patients and parents). Patients also completed the KINDL-R to measure HRQoL. Hierarchical multiple regression analyses were calculated.

Results
In acute treatment, patient’s perceptions of symptoms and cyclicity of their illness explained variation in their HRQoL in addition to sociodemographic and medical variables. In follow-up care, patient’s FoP and parent’s perception of consequences explained additional variation in patient’s HRQoL. Overall, sociodemographic and medical variables explained less variation in HRQoL in follow-up care than in acute treatment.

Conclusions
Our results stress the importance of psychological factors for the well-being of paediatric cancer patients, particularly in follow-up care, where sociodemographic and medical variables play a lesser role. We recommend screening for illness perceptions and FoP during and after acute treatment to support patients and parents. Furthermore, standardized interventions focussed on changing maladaptive illness perceptions should be developed and evaluated. As parents’ perceptions, thoughts, and feelings may also play an important role for the well-being of the patients, interventions should be family-focussed and include parents.
Trial registration The study has been pre-registered at the German Clinical Trials Register (registered 30/06/2020; DRKS00022034) and at the Open Science Framework (https://osf.io/3uwrx).
Does the likelihood of malignancy in thyroid nodules with RAS mutations increase in direct proportion with the allele frequency percentage?
Authors: Hudson Thomas J. , Pusztaszeri Marc Philippe , Hier Michael P. , Forest Veronique-Isabelle , Yang Ji-Wei , Payne Richard J. 
Published: February 2023

Background Genomic testing has enhanced pre-surgical decision making for cytologically indeterminate thyroid nodules, but there remains uncertainty regarding RAS mutations. The addition of extra genetic alterations to previous driver mutation panels has been shown to improve predictive value. This study aims to evaluate the relationship between the mutant allele frequency (AF) and likelihood of malignancy in thyroid nodules with RAS mutations. Methods A retrospective cohort review was performed evaluating patients with indeterminate cytology (Bethesda categories III, IV and V) and ThyroSeq® v3 testing demonstrating a RAS mutation, who underwent surgery. Univariate and multivariate regression analyses were used to evaluate relationships between AF, other genetic alterations, and malignancy. Results Thirty-nine patients met criteria, 77% of the thyroid nodules (30/39) were found to be malignant. None demonstrated aggressive pathology. On univariate regression, there was no relationship between AF and likelihood of malignancy. There was, however, a significant correlation between AF and the rate of an additional genetic alteration. Multivariate analysis found a trend between RAS, a second genetic alteration and malignancy, but it did not reach statistical significance. Conclusions There was no direct relationship between the level of allelic frequency in thyroid nodules expressing RAS mutations and the likelihood of malignancy. There was a statistically significant relationship between increasing AF and the presence of a second genetic abnormality, suggesting a possible progression from initial driver mutation and then a second genetic alteration prior to malignant transformation. Graphical Abstract
Well-concealed advanced duodenal carcinoma with Muir–Torre syndrome: a case report and review of literature
Authors: Sugi Tomoyuki , Shimomura Osamu , Hashimoto Shinji , Takahashi Kazuhiro , Doi Manami , Miyazaki Yoshihiro , Enomoto Tsuyoshi , Akashi Yoshimasa , Araki Kazuhisa , Oda Tatsuya 
Published: February 2023

Abstract
Background
Muir–Torre syndrome is an autosomal-dominant mutation in mismatch repair genes that gives rise to sebaceous tumors and visceral malignancies over time. Because colorectal and genitourinary cancers are common in Muir–Torre syndrome, duodenal carcinoma diagnoses are often delayed.

Case presentation
A 58-year-old woman presented with severe emaciation, anorexia, and upper abdominal pain. She had a history of rectal carcinoma, ascending colon carcinoma, and a right shoulder sebaceous carcinoma. Upper gastrointestinal endoscopy and computed tomography examinations suggested duodenal obstruction due to superior mesenteric artery syndrome, leading to long-term observation. Seven months later, she was finally diagnosed with duodenal carcinoma of the third portion. As the papilla of Vater was preservable due to tumor location, she received a partial duodenectomy in lieu of a pancreatoduodenectomy. Pathologically, the tumor was a well-differentiated adenocarcinoma with a classification of T3N0M0 Stage IIA (UICC, 8th edition). The postoperative course was uneventful and her appetite returned. A mutation in mismatch repair gene MSH2 confirmed the diagnosis of Muir–Torre syndrome genetically. Three years later, her nutritional status has fully recovered and she is free from both recurrence and metastasis.

Conclusion
In patients with comorbid skin sebaceous tumors and gastrointestinal malignancies, genetic screening is strongly recommended. Patients with Muir–Torre syndrome require long-term follow-up, and function-preserving treatment is desirable.
Nativeness versus intelligibility as goal of English pronunciation teaching in China: Changing attitudes in national syllabi and curriculum standards
Authors: Wang Ying , Wen Xu 
Published: February 2023

AbstractSince the 1990s, the emphasis on intelligibility as a goal in pronunciation teaching rather than near-native or nativelike competence has been reinforced by the increasing use of English as a lingua franca. The insight of the intelligibility principle has greatly impressed researchers in China’s English education, but has “very limited and weak” impacts on English pronunciation teaching and learning in China. English education in China has been systematically conducted from schools to universities under the direction of national syllabi and curriculum standards issued by the Ministry of Education. Using the documentary research method, this paper, the first try of its kind, takes a historical look at China’s national syllabi and curriculum standards for schools issued after 1949, focusing on the conception of the nature and the role of pronunciation and pronunciation teaching, pronunciation goals, teacher’s role, as well as requirements or suggestions about what to teach and how to teach. By tracing the process of developments in pronunciation teaching notions and principles that were and/or are officially advocated in China, the paper reveals two important facts. First, the English national syllabi and curriculum standards have encompassed both the nativeness principle and the intelligibility principle, though implicitly giving dominance to the former one, which in part accounts for the favor for the nativeness principle in formal English education, especially in schools, in China. Second, with the notion of English as a lingua franca adopted in the syllabi and curriculum standards, the intelligibility principle has been gaining more and more weight. Consequently, by elaborating that the two principles are by nature not incompatible, it is proposed that the current curriculum standards go further to take balanced attitudes towards the two principles so as to lead Chinese English teachers and students to set more realistic and instrumental-pragmatic pronunciation goals in line with varying English learning purposes. The findings and the proposal could be adopted by teachers and learners so as to change the school reality and may shed light on future relevant revisions of the current national English curriculum standards, teaching material development, teacher training, and pronunciation teaching methodology research.
When and where does it pay to be green? – A look into socially responsible investing and the cost of equity capital
Authors: Wang Yanbing , Delgado Michael S. , Xu Jin 
Published: February 2023

AbstractWe investigate the circumstances under which socially responsible investing (SRI) enhances firm long-term financial performance, and therefore provides incentives for firms to self-regulate their environmental performance. Aggregating portfolios across SRI mutual funds, we estimate the effect of SRI investment with environmental screening criteria on firm cost of equity capital. We find that accounting for interactions between firm and non-shareholder stakeholders, and potential agency costs associated with certain environmental activities of the firm, SRI can facilitate the alignment of firms’ environmental and financial goals. We also find that an industry group’s environmental performance and diversity influence the extent to which a firm in that group can benefit from SRI investment.
Contrast-enhanced mammography (CEM) versus MRI for breast cancer staging: detection of additional malignant lesions not seen on conventional imaging
Authors: Taylor Donna B. , Burrows Sally , Saunders Christobel M. , Parizel Paul M. , Ives Angela 
Published: February 2023

Abstract
Background
Contrast-enhanced mammography (CEM) is more available than MRI for breast cancer staging but may not be as sensitive in assessing disease extent. We compared CEM and MRI in this setting.

Methods
Fifty-nine women with invasive breast cancer underwent preoperative CEM and MRI. Independent pairs of radiologists read CEM studies (after reviewing a 9-case set prior to study commencement) and MRI studies (with between 5 and 25 years of experience in breast imaging). Additional lesions were assigned National Breast Cancer Centre (NBCC) scores. Positive lesions (graded NBCC ≥ 3) likely to influence surgical management underwent ultrasound and/or needle biopsy. True-positive lesions were positive on imaging and pathology (invasive or in situ). False-positive lesions were positive on imaging but negative on pathology (high-risk or benign) or follow-up. False-negative lesions were negative on imaging (NBCC < 3 or not identified) but positive on pathology.

Results
The 59 women had 68 biopsy-proven malignant lesions detected on mammography/ultrasound, of which MRI demonstrated 66 (97%) and CEM 67 (99%) (p = 1.000). Forty-one additional lesions were detected in 29 patients: six of 41 (15%) on CEM only, 23/41 (56%) on MRI only, 12/41 (29%) on both; CEM detected 1/6 and MRI 6/6 malignant additional lesions (p = 0.063), with a positive predictive value (PPV) of 1/13 (8%) and 6/26 (23%) (p = 0.276).

Conclusions
While MRI and CEM were both highly sensitive for lesions detected at mammography/ultrasound, CEM may not be as sensitive as MRI in detecting additional otherwise occult foci of malignancy.

Trial registration
Australian and New Zealand Clinical Trials Registry: ACTRN 12613000684729
Identification and virulence of entomopathogenic fungi, Isaria javanica and Purpureocillium lilacinum isolated from the whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) in Malaysia
Authors: Sani Ibrahim , Jamian Syari , Saad Norsazilawati , Abdullah Sumaiyah , Mohd Hata Erneeza , Jalinas Johari , Ismail Siti Izera 
Published: February 2023

Abstract
Background
Three of entomopathogenic fungi, identified as Isariajavanica (Cjc-03 and Cjw-01) and Purpureocilliumlilacinum (TS-01) were found naturally infecting the whiteflies, Bemisiatabaci (Gennadius) (Hemiptera: Aleyrodidae) on chili and tomato plants. All the isolates were identified by morphological characterization and molecular identification (ITS region amplification). The virulence of the three isolates was evaluated against nymphs of B.tabaci at three different concentrations (1 × 106, 1 × 107, and 1 × 108 conidia/ml) under laboratory conditions and on adults of B.tabaci at one conidia concentration (1 × 107 conidia/ml) under laboratory and glasshouse conditions.

Results
Isariajavanica showed the highest virulence against B.tabaci nymphs and adults in both laboratory and glasshouse conditions. I.javanica exhibited the highest mortality in the laboratory against B.tabaci, nymphs at the highest concentration (1 × 108 conidia/ml) 8 days post-inoculation. Likewise, in the laboratory bioassay, B.tabaci, adults, Cjc-03 isolate exhibited maximum mortality (80.0%), followed by Cjw-01 isolate (77.5%), and TS-01 isolate (65.0%) at the concentration of 1 × 107 conidia/ml at 7 days post-inoculation. The highest mortality rate (63.45%) was recorded by the Cjc-03 isolate and TS-01 (54.22%) isolate at 3 days post-inoculation in glasshouse bioassay using the concentration of 1 × 107 conidia/ml of each of the 2 isolates (Cjc-03 and TS-01) against B.tabaci adults.

Conclusion
Overall, the findings showed that both isolates of I.javanica and P.lilacinum reduced the number of eggs, nymphs, and adults’ emergence of B.tabaci, following the application of 1 × 107 conidia/ml on tomato leaves in the glasshouse. The newly isolated strains could be developed as a potential commercial biopesticide for managing B.tabaci.
Beverage preference (coffee vs. tea) according to CYP1A2 gene rs2470893 SNP genotypes in the Tunisian population
Authors: Denden Sabri , Sellami Mohamed Hichem , Kibech Ridha , Haj Khelil Amel , Hamdaoui Mohamed Hédi 
Published: February 2023

Abstract
Background
Caffeine intake has been positively or negatively associated with the risk of chronic disease. Genome-wide association studies identified single-nucleotide polymorphisms (rs2472297 and rs2470893) in Cytochrome P450 1A2 (CYP1A2) gene that are involved in habitual caffeine intake. In this study, we investigated the association of common CYP1A2 SNPs (rs762551, rs2472297 and rs2470893) with most consumed caffeinated beverages intake (coffee and tea) in the Tunisian population. Five hundred and twenty healthy blood donors were enrolled. Coffee and tea intake data were extracted from dietary questionnaires of the participants. Genotyping was performed using PCR–RFLP. p < 0.05 was considered as statistically significant.

Results
There were no significant genetic effects of rs762551 and rs2472297 SNPs on coffee (p = 0.083 and p = 0.70) or tea (p = 0.49 and p = 0.49) consumption, respectively. However, rs2470893 SNP A carriers displayed higher coffee consumption [p = 0.001, OR (95% CI) 1.46 (1.16–1.86)] and lower tea consumption [p = 0.001, OR (95% CI) 0.80 (0.70–0.97)]. After stratification by confounding factors, the genetic effect was observed in women (1.2% of variation in coffee intake and 9.6% of variation in tea intake), subjects ≤ 35 years (1.5% of variation in coffee intake) and nonsmokers (1.4% of variation in tea intake).

Conclusions
Our data are consistent with a beverage preference (coffee vs. tea) according to rs2470893 SNP genotypes (A carriers vs. GG). Furthermore, genetic variation is significant at the condition of lower CYP1A2 enzyme activity (among women, nonsmokers and younger age groups).