bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of ESBLs and carbapenemases among Enterobacterales and carbapenemases in Pseudomonas aeruginosa isolates collected globally: results from ATLAS 2017–2019
Authors: Gales Ana C , Stone Gregory , Sahm Daniel F , Wise Mark G , Utt Eric 
Published: May 2023

Abstract

Objectives
To assess the global and regional distribution of ESBLs in Enterobacterales and carbapenemases in Enterobacterales and Pseudomonas aeruginosa.

Methods
Antimicrobial susceptibility of isolates collected from ATLAS (2017–2019) was determined per CLSI guidelines. Enterobacterales exhibiting meropenem MICs ≥2 mg/L and/or ceftazidime/avibactam and/or aztreonam/avibactam MICs ≥16 mg/L, Escherichia coli and Klebsiella pneumoniae with aztreonam and/or ceftazidime MICs ≥2 mg/L, and P. aeruginosa with meropenem MICs ≥4 mg/L were screened for β-lactamases by PCR and sequencing.

Results
Globally, ESBL-positive E. coli (23.7%, 4750/20047) and K. pneumoniae (35.1%, 6055/17229) carried predominantly the CTX-M-15 variant (E. coli: 53.9%; K. pneumoniae: 80.0%) with highest incidence in Africa/Middle East (AfME). Among carbapenem-resistant (CR) E. coli (1.1%, 217/20047) and Enterobacter cloacae (3.8%, 259/6866), NDMs were predominant (E. coli in AfME: 62.5%; E. cloacae in Asia Pacific: 59.7%). CR K. pneumoniae (13.3%, 2299/17 229) and P. aeruginosa (20.3%, 4187/20 643) carried predominantly KPC (30.9%) and VIM (14.7%), respectively, with highest frequency in Latin America. Among ESBL-positive Enterobacterales, susceptibility to ceftazidime/avibactam (&gt;90.0%) and amikacin (&gt;85.0%) was higher than to piperacillin/tazobactam (&gt;45.0%) and ciprofloxacin (&gt;7.4%). In CR Enterobacterales, susceptibility to amikacin (&gt;54.0%) and ceftazidime/avibactam (&gt;31.0%) was higher than to ciprofloxacin (&gt;2.7%) and piperacillin/tazobactam (&gt;0.5%). CR P. aeruginosa similarly demonstrated higher susceptibility to amikacin (63.4%) and ceftazidime/avibactam (61.9%) than to ciprofloxacin (26.2%) and piperacillin/tazobactam (25.3%).

Conclusions
Varied distribution of resistance genotypes across regions among ESBL-positive Enterobacterales and CR Enterobacterales and P. aeruginosa provide crucial insights on major resistance mechanisms and trends observed in recent years. Continued surveillance is warranted for monitoring global dissemination and resistance.
Heritability of beef cow metabolizable energy for maintenance
Authors: Freetly Harvey C , Jacobs Devin R , Thallman R Mark , Snelling Warren M , Kuehn Larry A 
Published: May 2023

Abstract
Most of the metabolizable energy that a cow uses during a production year is for maintenance; however, less is known about the heritability of maintenance compared to other traits that can be measured directly. Feed intake is a heritable trait in the mature cow and most of the feed consumed is used for maintenance. We hypothesized that maintenance energy was a heritable trait. Individual feed intake was measured for 84 or 85 d on 5 yr old pregnant cows (N = 887) from a pedigreed population of cattle that represent prominent breeds in the United States. Phenotypic mean (± SD) values were 654 ± 68 kg for cow body weight, 0.21 ± 0.24 kg/d for average daily gain, and 175 ± 17 d for midpoint fetal age. Dry matter intake averaged (± SD) 10.84 ± 1.41 kg/d. Metabolizable energy for maintenance was estimated by subtracting the metabolizable energy used for conceptus growth and tissue accretion from metabolizable energy intake. Metabolizable energy for maintenance averaged (± SD) 139 ± 18 ME kcal/d/BW kg0.75 and had a heritability of 0.31 ± 0.11. Cows have a moderate heritability for maintenance suggesting an opportunity for selection.
“Want” versus “Need”: How Linguistic Framing Influences Responses to Crowdfunding Appeals
Authors: Su Lei , Sengupta Jaideep , Li Yiwei , Chen Fangyuan 
Published: May 2023

Abstract
This research uses a crowdfunding context to examine when and why a simple difference in frame—using “want” versus “need” in the request—affects funders’ compliance with an appeal for contributions. Building on the semantic framing and psycholinguistics literature, we propose that using “want” (vs. “need”) signals that the fundraiser is a relatively less (vs. more) dependent person. This perception difference then exerts opposing effects on the two major forms of crowdfunding appeals. For reward-based appeals, in which fundraisers promise a return on contribution, funders have a for-profit (i.e., incentive-seeking) goal and are more willing to contribute to a less dependent fundraiser. In contrast, for donation-based appeals, in which no incentives are promised by the fundraisers, funders are primarily motivated by a nonprofit (i.e., helping) goal and are more willing to contribute to a fundraiser who is seen as more dependent on help. Therefore, we predict that a “want” (vs. “need”) frame is more effective in reward-based (vs. donation-based) crowdfunding. Results from two large-scale observational studies and four experiments support our predictions and also illuminate the underlying mechanisms. Collectively, the findings contribute to the literature on semantic framing and crowdfunding and also offer practical implications for fundraisers, marketers, and policymakers.
No evidence of inbreeding depression despite a historical severe bottleneck in the endangered Bermuda petrel (Pterodroma cahow)
Authors: Afonso Rita O , Pina-Martins Francisco , Friesen Vicki , Sun Zhengxin , Campioni Letizia , Madeiros Jeremy , Silva Mónica C 
Published: May 2023

Abstract
The Bermuda petrel Pterodroma cahow is an island endemic seabird that belongs to the Procellariiformes, one of the most endangered orders of birds. Historical records suggest a significant population size decline following human settlement in Bermuda, bringing the species to near extinction. Since the 1950s, the population has been recovering aided by the implementation of an ongoing conservation plan. However, it still faces several threats, and negative genetic effects resulting from that drastic decline are to be expected, including inbreeding and genetic drift. We studied genetic diversity and levels of inbreeding, and their effects on individual fitness and mating choice. We also tested for a genetic signature of the recent demographic bottleneck. For this, we analyzed variation in thousands of nuclear single-nucleotide polymorphisms derived from double digest restriction site-associated DNA sequencing and 1 mitochondrial gene (cytochrome oxidase I). The results revealed that the Bermuda petrel suffered a recent genetic bottleneck and shows low mitochondrial diversity compared with other petrel species. Conversely, nuclear diversity was similar to that of other endangered petrels. Inbreeding levels were not high overall, although some individuals were highly inbred. However, we found no evidence that individual inbreeding or relatedness between mates affected hatching success, or that mate choice is influenced by kinship in this very small population.
The Quadrilemma: Appointing Adjudicators in Future Investor–State Dispute Settlement
Authors: Langford Malcolm , Behn Daniel , Malaguti Maria Chiara 
Published: May 2023

ABSTRACT
Concern with the selection and appointment of arbitrators has been central in the ‘legitimacy crisis’ surrounding investor–state dispute settlement (ISDS). The regime has been criticized for the outsized role of litigating parties in appointment, absence of transparency in the appointment procedure, potential for conflicts of interests, lack of diversity, and little emphasis on public international law competence. However, attempts to reform the selection and appointment of adjudicators involve confronting dilemmas, requiring trade-offs between different normative values. We therefore introduce a quadrilemma that captures the underlying values of independence, accountability, diversity, and procedural fairness that actors often seek to realize through adjudicatory design. We then set out seven idealized selection and appointment reform options under discussion in the ISDS reform process at UN Commission on International Trade Law (UNCITRAL) (from incremental reform through to new permanent mechanisms and removal of ISDS). The quadrilemma is employed to analyse their advantages and disadvantages of each model. In light of empirical and doctrinal evidence, it is clear that some reform options are more likely than others to optimize the quadrilemma. However, the effects are often conditional and sometimes there is a need for accompanying mechanisms.
Modelling the Diffusion of the Deterrent Effects of Competition Policy
Authors: Dierx Adriaan , Ilzkovitz Fabienne , Pataracchia Beatrice , Pericoli Filippo 
Published: May 2023

Abstract
Through its competition policy interventions, the European Commission not only addresses infringements of EU competition law by the firms directly involved but also deters possible future anticompetitive behaviour by these firms and other market players. The present paper associates deterrence with the diffusion of information about the competition authority’s interventions to market players. In the mixed-influence diffusion model developed below, competition policy interventions act as an external signal sent to market players. Interactions between market players, in particular through legal counsels and law firms, further propagate the interventions’ deterrent effects. The focus of the model simulations is on interventions by the European Commission. The parameters of the mixed-influence diffusion model are calibrated using survey-based information on the order of magnitude of the deterrent effects of competition policy interventions and an assessment of the reputation of the European Commission as an enforcer of EU competition rules. On this basis, estimates of the deterrent effect of each individual intervention by the European Commission can be obtained. In addition, the sensitivity of the deterrent effects of competition policy interventions to the reputation of the competition authority and to the importance of interactions between market participants is analysed.
Fatigue in Children and Adolescents: A Population-Based Longitudinal Study on Fatigue and Chronic Pain
Authors: Sommer Ariane , Grothus Susanne , Claus Benedikt B , Stahlschmidt Lorin , Wager Julia 
Published: May 2023

AbstractObjectiveThere are limited data on the prevalence and stability of fatigue in pediatrics, particularly among youth with chronic pain. Little is known about longitudinal effects of fatigue on health outcomes such as sleep quality, psychological distress, Health-Related Quality of Life, and chronic pain.MethodsA community-based sample of N = 1276 students (9–17 years; 52% female; 30.3% with chronic pain) from 3 schools was screened at 2 measurement points 3 months apart. Prevalence and stability of fatigue were examined. Longitudinal analyses regarding fatigue and health outcomes were run using repeated measures correlations. The impact of change in fatigue on pain progression was analyzed using multilevel linear models.ResultsIn the total community sample, 4.4% reported severe fatigue symptoms. The prevalence of severe fatigue was significantly higher in students with chronic pain (11.4%) compared to those without (1.3%). Fatigue symptoms persisted for several months, worsening of symptoms was more common and improvement less common in children with chronic pain. Sleep, psychological distress, and Health-Related Quality of Life were significantly associated with fatigue across both measurement points (rs = |0.16–0.44|), with no significant differences in the strength of correlations between children with and without chronic pain (ps &gt; .05). There was a significant interaction between change in fatigue and courses of pain intensity and functional impairment.ConclusionsFatigue is highly prevalent, particularly in youth with chronic pain. The negative association of fatigue with health outcomes, and its impact on the course of pain, require early identification and treatment of those affected to prevent negative long-term consequences.
Predicting the effect of pharmacist’s communication with patients: medical communication analysis using facial responses
Authors: Miyagi Yukina , Gocho Saori , Yamaguchi Naoko , Miyachi Yuka , Nakayama Chika , Okada Shoshiro , Oshima Taeyuki 
Published: May 2023

Abstract

Objectives
To provide patient-centred care, psychological knowledge, and skills are necessary for pharmaceutical communication. Acquisition of these communication skills is closely related to patient comprehension. Therefore, to improve pharmacist’s communication skills, pharmacist need to learn the characteristics of their medication instructions, such as posture, facial expressions, eye contact, nodding, and more. For the analysis of medical communication, there is a rating scale, functional analysis, and others. However, these methods may not match the actual emotions due to their analysis skills and the psychological stress of the patients. In this study, we examined the methods to evaluate patient-pharmacist communication using emotion recognition AI software, which recognises emotions from facial expressions.

Methods
With the cooperation of six simulated patients (SP) and eight pharmacists, we recorded the SP’s facial expressions during medication instruction. The facial expression video was analysed using emotion recognition AI, which can obtain emotion values (anger, contempt, disgust, fear, joy, sadness, surprise, and engagement). We compared the emotion of the extracted peaks with the feedback and calculated the emotion match rate.

Key findings
As a result, 33% of the emotions matched in the peak and feedback. This result indicates that emotion recognition AI cannot capture every feedback emotion. However, in joy, the result was not affected by engagement, and the match rate between peak and feedback was high.

Conclusions
In the future, emotion recognition AI will allow us to assess the effects of communication skills of the pharmacists on the psychological state of the patients more objectively and noninvasively.
Extended biosynthesis of rhamnolipid by immobilized Pseudomonas aeruginosa USM-AR2 cells in a fluidized bed bioreactor
Authors: Zulkhifli Nur Ardhani Mohammed , Solong Dewi Rohayuh , Mohd Yahya Ahmad Ramli , Noh Nur Asshifa Md 
Published: May 2023

Abstract
This study aims to evaluate rhamnolipid production by immobilized Pseudomonas aeruginosa USM-AR2 cells using waste cooking oil (WCO) as the carbon source. P. aeruginosa USM-AR2 cells were entrapped in polyvinyl alcohol (PVA)-alginate hydrogel beads. The performance of entrapped cells was compared with free cells in shake flasks before cultivation in a custom-designed fluidized bed reactor (FBR). A mass of 1 g of wet cells entrapped in PVA-alginate hydrogel beads was successfully recycled three times in shake flasks at 200 rpm, producing between 0.66 to 1.34 g L−1 rhamnolipid after 120 h. Meanwhile, cultivation of entrapped cells in FBR with broth recirculation showed that the suitable hydrogel beads to medium ratio was 1:20 at an aeration rate of 0.5 vvm, producing between 0.77 to 1.58 g L−1 rhamnolipid and degrading 8.67 to 20.93g L−1 of waste cooking oil in 15 cycles of repeated batch cultivation. Entrapped P. aeruginosa USM-AR2 cells achieved a higher rhamnolipid production by 1.03-fold during cycle 3 in shake flasks and 1.19-fold during cycle 11 in an FBR, compared to free cells. These results show that entrapment enables the reusability of viable cells and maintains the stability of rhamnolipid production throughout the extended cultivation, increasing cell tolerance to perturbations in fermentation conditions.
Practices and Policies That Support Breastfeeding Among Military Women: A Systematic Review
Authors: Owens Bridget A , DiTomasso Diane 
Published: May 2023

ABSTRACT

Background
Previous and limited assessments of breastfeeding in women serving on active duty in the U.S. military demonstrate varied and conflicting data regarding breastfeeding outcomes. Disparities exist within the military where enlisted service members have consistently lower rates of breastfeeding duration compared to officers. Yet, little is known about successful care practices and military policies that promote breastfeeding in military women. The aim of this systematic review is to examine care practices and military policies associated with increased breastfeeding initiation and duration among women serving in the U.S. military.

Materials and Methods
We searched Cochrane Database, Cumulative Index of Nursing and Allied Health Literature, PubMed, and PsycInfo for studies published from 2000 to 2022 that included U.S. military personnel and that focused on care practices and military policies that support breastfeeding. Our search terms included (breastfeeding OR breastfeed AND military) and (lactation OR lactating AND military). We included randomized controlled trials, quasi-experimental, cohort, cross-sectional, and other observational designs. We evaluated potential bias in studies using the Evidence Project Risk of Bias Tool and synthesized the overall evidence using the Johns Hopkins Nursing Evidence-Based Practice Synthesis and Recommendations Tool.

Results
We included 14 studies that were independently reviewed by two authors. Breastfeeding initiation rates among military women were between 66% and 98%, and breastfeeding duration rates at 6 months ranged from 13% to 62%. In these studies, researchers examined various inpatient care practices (skin-to-skin care, timing of circumcision, and infant baths) (n = 3), care delivered by different types of providers (n = 3), group versus individual prenatal care (n = 2), breastfeeding education (n = 2), length of maternity leave (n = 2), and workplace support (n = 2). Skin-to-skin contact following delivery was positively associated with breastfeeding outcomes. There is insufficient evidence to determine if care by different types of medical providers, different types of prenatal care and education, timing of circumcision or baths, length of maternity leave, and workplace support influence breastfeeding outcomes.

Conclusion
Certain perinatal practices designed to encourage early skin-to-skin contact appear to improve breastfeeding initiation and duration among women serving in the U.S. military. However, there is an overall lack of quality evidence supporting effective practices and policies associated with increased breastfeeding initiation and duration in this population. Given the recent movement toward policy changes that support pregnant and postpartum service members across services, more research is needed to determine the impact of these and other practices and policies on breastfeeding rates, specifically among enlisted service members who have demonstrated lower breastfeeding rates than officers.
Chemotherapy Treatment Costs and Clinical Outcomes of Colon Cancer in the U.S. Military Health System’s Direct and Private Sector Care Settings
Authors: Eaglehouse Yvonne L , Seabury Seth A , Aljehani Mayada , Koehlmoos Tracey , Lee Jerry S H , Shriver Craig D , Zhu Kangmin 
Published: May 2023

ABSTRACT

Introduction
Identifying low-value cancer care may be an important step in containing costs associated with treatment. Low-value care occurs when the medical services, tests, or treatments rendered do not result in clinical benefit. These may be impacted by care setting and patients’ access to care and health insurance. We aimed to study chemotherapy treatment and the cost paid by the Department of Defense (DoD) for treatment in relation to clinical outcomes among patients with colon cancer treated within the U.S. Military Health System’s direct and private sector care settings to better understand the value of cancer care.

Materials and Methods
A cohort of patients aged 18 to 64 years with primary colon cancer diagnosed between January 1, 1999, and December 31, 2014, were identified in the Military Cancer Epidemiology database. Multivariable time-dependent Cox proportional hazards regression models were used to assess the relationship between chemotherapy treatment and the cost paid by the DoD (in quartiles, Q) and the outcomes of cancer progression, cancer recurrence, and all-cause death modeled as adjusted hazard ratios (aHRs) and 95% confidence intervals (95% CIs). The Military Cancer Epidemiology data were approved for research by the Uniformed Services University of the Health Sciences’ Institutional Review Board.

Results
The study included 673 patients using direct care and 431 patients using private sector care. The median per patient chemotherapy costs in direct care ($111,202) were lower than in private sector care ($350,283). In direct care, higher chemotherapy costs were associated with an increased risk of any outcome but not with all-cause death. In private sector care, higher chemotherapy costs were associated with a higher risk of any outcome and with all-cause death (aHR, 2.67; 95% CI, 1.20-5.92 for Q4 vs. Q1).

Conclusions
The findings in the private sector may indicate low-value care in terms of the cost paid by the DoD for chemotherapy treatment and achieving desirable survival outcomes for patients with colon cancer in civilian health care. Comprehensive evaluations of value-based care among patients treated for other tumor types may be warranted.
Sensitivity study of chemistry in AGB outflows using chemical kinetics
Authors: Maes S , Van de Sande M , Danilovich T , De Ceuster F , Decin L 
Published: May 2023

ABSTRACT
Asymptotic giant branch (AGB) stars shed a significant amount of their mass in the form of a stellar wind, creating a vast circumstellar envelope (CSE). Owing to the ideal combination of relatively high densities and cool temperatures, CSEs serve as rich astrochemical laboratories. While the chemical structure of AGB outflows has been modelled and analysed in detail for specific physical setups, there is a lack of understanding regarding the impact of changes in the physical environment on chemical abundances. A systematic sensitivity study is necessary to comprehend the nuances in the physical parameter space, given the complexity of the chemistry. This is crucial for estimating uncertainties associated with simulations and observations. In this work, we present the first sensitivity study of the impact of varying outflow densities and temperature profiles on the chemistry. With the use of a chemical kinetics model, we report on the uncertainty in abundances, given a specific uncertainty on the physical parameters. In addition, we analyse the molecular envelope extent of parent species and compare our findings to observational studies. Mapping the impact of differences in physical parameters throughout the CSE on the chemistry is a strong aid to observational studies.