bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum levels of erythropoietin in patients with chronic obstructive pulmonary disease and anemia
Authors: Rezvani Alireza , Masoompour Seyed Masoom , Azarpira Negar , Monjazeb Raha , Akbarzadeh Majid , Salimi Maryam , Shahriarirad Reza 
Published: April 2023

AbstractThe important association of erythropoietin (EPO) serum levels and chronic obstructive pulmonary disease (COPD) with anemia has been inadequately studied and remains a controversial issue. We aimed to shed light on this matter by comparing EPO levels in anemic and non-anemic COPD patients, along with a review of published literature. This cross-sectional study was conducted on COPD patients referred to the pulmonary clinic of Shahid Faghihi Hospital and Motahari clinic, Shiraz, Iran, for one year. We measured complete blood count, red blood cell indices, serum iron, TIBC and ferritin levels, serum EPO levels, and body mass index. Among 35 patients in this study, 28 males and 7 females were enrolled with a mean age of 54.57 ± 8.07 years. The average Forced expiratory volume in first second (FEV1) was 37.26 ± 7.33% and FEV1/FVC was 0.46 ± 0.12. Mean EPO levels were 30.29 ± 2.066 mU/mL. No statistically significant association was observed among erythropoietin levels and Hb, COPD severity, and age. There was no significant difference in EPO levels between anemic and non-anemic patients. EPO level, against the traditional expectation, didn’t increase in COPD patients. EPO production also didn’t compensate for the anemia of chronic disease which considers as a common comorbid disorder in these patients.
In Support of a Public Health Approach to Late Talking
Authors: Neiling Sarah Lynn , Cutshaw Christina A. 
Published: April 2023

Purpose:
This article aims to support and extend Di Sante and Potvin's (2022) viewpoint, “We Need to Talk About Social Inequalities in Language Development,” by providing additional detail on a proposed public health approach to language development and late talking specifically. A public health approach can be a model for the field of speech-language pathology to improve child language across social gradients and reduce inequities in late talking.

Method:
A public health approach is defined and compared to the clinical approach. A proposal for how a public health approach could be applied to address inequities in late talking is described.

Conclusions:
A public health approach merits consideration by leaders and institutions in the field of speech-language pathology. This approach draws attention to the role of social determinants of language development and the need to address structures and systems that not only support clinical intervention to address disorders but also that focus on prevention of late talking and promotion of healthy language development. A public health approach requires engaging stakeholders outside the field of speech-language pathology, thus strengthening opportunities for progress.
Features of Cognitive Ability and Central Auditory Processing of Preschool Children With Minimal and Mild Hearing Loss
Authors: Ji Hui , Yu Xinyue , Xiao Zhenglu , Zhu Huiqin , Liu Panting , Lin Huanxi , Chen Renjie , Hong Qin 
Published: April 2023

Objective:
This study aimed to investigate the current status of cognitive development and central auditory processing development of preschool children with minimal and mild hearing loss (MMHL) in Nanjing, China.

Method:
We recruited 34 children with MMHL and 45 children with normal hearing (NH). They completed a series of tests, including cognitive tests (i.e., Wechsler Preschool and Primary Scale of Intelligence and Continuous Performance Test), behavioral auditory tests (speech-in-noise [SIN] test and frequency pattern test), and objective electrophysiological audiometry (speech-evoked auditory brainstem response and cortical auditory evoked potential). In addition, teacher evaluations and demographic information and questionnaires completed by parents were collected.

Results:
Regarding cognitive ability, statistical differences in the verbal comprehensive index, full-scale intelligence quotient, and abnormal rate of attention test score were found between the MMHL group and the NH group. The children with MMHL performed poorer on the SIN test than the children with NH. As for the auditory electrophysiology of the two groups, the latency and amplitude of some waves of the speech-evoked auditory brainstem response and cortical auditory evoked potential were statistically different between the two groups. We attempted to explore the relationship between some key indicators of auditory processing and some key indicators of cognitive development.

Conclusions:
Children with MMHL are already at increased developmental risk as early as preschool. They are more likely to have problems with attention and verbal comprehension than children with NH. This condition is not compensated with increasing age during the preschool years. The results suggest a possible relationship between the risk of cognitive deficit and divergence of auditory processing.

Supplemental Material:

https://doi.org/10.23641/asha.22670473
Speech-Language Pathology Treatment of Cognitive-Communication Deficits in School-Aged Children With Traumatic Brain Injury: A Scoping Review
Authors: Crook Libby , Riccardi Jessica S. , Ruddock Hannah S. , Ciccia Angela 
Published: April 2023

Purpose:
The purpose of this scoping review was to synthesize the current evidence-based treatment practices used with school-aged children with any severity of traumatic brain injury (TBI) that could benefit the practice of speech-language pathologists (SLPs).

Method:
A scoping review of the literature was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines. Included studies were assigned thematic labels based on a modified version of the Rehabilitation Treatment Specification System.

Results:

A total of 27 articles that covered 16 different treatment approaches met inclusion criteria for this study. Most studies included adolescent or teenage participants with moderate–severe TBIs. Treatment targets included executive functioning (
n
= 15), social competence (
n
= 6), postconcussive symptoms (
n =
5), behavior (
n =
3), family functioning (
n =
1), and health-related quality of life (
n =
1). The majority of current interventions for school-aged children with TBI include a multidisciplinary approach and components of family involvement education.

Conclusions:
Further research is needed on interventions that are specifically implemented by SLPs as well as protocols that include more heterogeneous samples (e.g., varied sociodemographic factors and injury severity) to allow for the development and testing of ecologically valid intervention practice. SLPs can use the results of this scoping review to individualize treatment based on the child's areas of need while considering individual characteristics and to provide person-centered intervention for children with school-aged TBI.
Factors Associated With Resident Intake of Thickened Liquids in Long-Term Care
Authors: Werden Abrams Sophia , Keller Heather , Carrier Natalie , Lengyel Christina , Slaughter Susan E. , Namasivayam-MacDonald Ashwini 
Published: April 2023

Purpose:
Hydration is essential for health; however, long-term care (LTC) residents consume less fluid than is recommended, which may contribute to dehydration. Residents who drink thickened liquids likely consume even less than peers. Therefore, the aims of this study were to (a) determine if LTC residents who drink thickened liquids consume less fluid compared to those consuming thin liquids and (b) determine factors associated with fluid intake of residents who drink thickened liquids.

Method:

Participants who drank thickened liquids (
n
= 68) were compared with participants who drank thin liquids (
n
= 68). Fluid intake, cognition, diet prescription, and mealtime challenges were compared between groups. A stepwise multiple regression model assessed variables associated with fluid intake of residents who consumed thickened fluids.

Results:
All participants consumed less than recommended fluid volumes. No statistically significant difference was found in fluid intake between groups; however, the group consuming thickened liquids drank less than those consuming thin liquids. The thickened liquid group was also more likely to eat a modified diet, had higher levels of cognitive impairment, and had more mealtime challenges requiring more assistance. As age increased, thickened liquid intake decreased across study participants.

Conclusion:
These results highlight the need for interventions in LTC to support fluid intake in this vulnerable population.
Weakly supervised machine learning
Authors: Ren Zeyu , Wang Shuihua , Zhang Yudong 
Published: April 2023

AbstractSupervised learning aims to build a function or model that seeks as many mappings as possible between the training data and outputs, where each training data will predict as a label to match its corresponding ground‐truth value. Although supervised learning has achieved great success in many tasks, sufficient data supervision for labels is not accessible in many domains because accurate data labelling is costly and laborious, particularly in medical image analysis. The cost of the dataset with ground‐truth labels is much higher than in other domains. Therefore, it is noteworthy to focus on weakly supervised learning for medical image analysis, as it is more applicable for practical applications. In this review, the authors give an overview of the latest process of weakly supervised learning in medical image analysis, including incomplete, inexact, and inaccurate supervision, and introduce the related works on different applications for medical image analysis. Related concepts are illustrated to help readers get an overview ranging from supervised to unsupervised learning within the scope of machine learning. Furthermore, the challenges and future works of weakly supervised learning in medical image analysis are discussed.
An artificial systems, computational experiments and parallel execution‐based surface electromyogram‐driven anti‐disturbance zeroing neurodynamic strategy for upper limb human‐robot interaction control
Authors: Liu Yongbai , Liu Keping , Wang Gang , Zhang Jiliang , Chou Yao , Sun Zhongbo 
Published: April 2023

AbstractIn recent years, intelligent robots are extensively applied in the field of the industry and intelligent rehabilitation, wherein the human‐robot interaction (HRI) control strategy is a momentous part that needs to be ameliorated. Specially, the efficacy and robustness of the HRI control algorithm in the presence of unknown external disturbances deserve to be addressed. To deal with these urgent issues, in this study, artificial systems, computational experiments and a parallel execution intelligent control framework are constructed for the HRI control. The upper limb‐robotic exoskeleton system is re‐modelled as an artificial system. Depending on surface electromyogram‐based subject's active motion intention in the practical system, a non‐convex function activated anti‐disturbance zeroing neurodynamic (NC‐ADZND) controller is devised in the artificial system for parallel interaction and HRI control with the practical system. Furthermore, the linear activation function‐based zeroing neurodynamic (LAF‐ZND) controller and proportional‐derivative (posterior deltoid (PD)) controller are presented and compared. Theoretical results substantiate the global convergence and robustness of the proposed controller in the presence of different external disturbances. In addition, the simulation results verify that the NC‐ADZND controller is better than the LAF‐ZND and the PD controllers in respect of convergence order and anti‐disturbance characteristics.
Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm
Authors: Loharkar Sarvesh , Basu Sandip 
Published: April 2023

AbstractA 50-year-old female patient of heavily pre-treated (chemotherapy and multiple treatment-resistant) and progressive intermediate-grade metastatic neuroendocrine neoplasm is presented, wherein the lesions showed mixed response following topotecan treatment and multiple hepatic metastasis showed increase in the SSTR expression and decrease in FDG concentration on dual-tracer PET/CT (68Ga-DOTATATE and 18F-FDG PET/CT). Such observation allowed 177Lu-DOTATATE PRRT to be considered for an advanced, symptomatic, and multiple treatment-resistant patient with limited palliative treatment options left.
Performance Monitoring and Cognitive Inhibition during a Speech-in-Noise Task in Older Listeners
Authors: Ryan David B. , Eckert Mark A. , Sellers Eric W. , Schairer Kim S. , McBee Matthew T. , Ridley Elizabeth A. , Smith Sherri L. 
Published: April 2023

AbstractThe goal of this study was to examine the effect of hearing loss on theta and alpha electroencephalography (EEG) frequency power measures of performance monitoring and cognitive inhibition, respectively, during a speech-in-noise task. It was hypothesized that hearing loss would be associated with an increase in the peak power of theta and alpha frequencies toward easier conditions compared to normal hearing adults. The shift would reflect how hearing loss modulates the recruitment of listening effort to easier listening conditions. Nine older adults with normal hearing (ONH) and 10 older adults with hearing loss (OHL) participated in this study. EEG data were collected from all participants while they completed the words-in-noise task. It hypothesized that hearing loss would also have an effect on theta and alpha power. The ONH group showed an inverted U-shape effect of signal-to-noise ratio (SNR), but there were limited effects of SNR on theta or alpha power in the OHL group. The results of the ONH group support the growing body of literature showing effects of listening conditions on alpha and theta power. The null results of listening condition in the OHL group add to a smaller body of literature, suggesting that listening effort research conditions should have near ceiling performance.
Treatment Results of Vocal Process Granuloma: Intubation versus Contact Granuloma
Authors: Woo Joo Hyun , Oh Jae Hwan , Lim Byung Woo , Kim Dong Young 
Published: April 2023

Abstract
Introduction Contact granulomas (CGs) and intubation granulomas (IGs) are known to have different clinical manifestations despite having the same pathological features.
Objective The purpose of the present study was to analyze the treatment results for CG and IG and to obtain clinical information.
Methods We retrospectively reviewed the medical records of patients diagnosed with vocal process granuloma (VPG) between January 2015 and December 2018. The patient's age, sex, medical history, lesion size, lesion type, reflux finding score (RFS), response to treatment, duration of treatment, and follow-up period were compared.
Results Eighteen patients with CG and 14 patients with IG were included in the study. The IG group had more female patients (p = 0.0009), showed better response to proton pump inhibitor (PPI) and steroid inhalation (SI) (p = 0.036), and had a shorter treatment period (p = 0.0029) than the CG group. Five patients who received botulinum toxin injections in their vocal cords had complete remission.
Conclusion Compared with CG, IG was more responsive to treatment with PPI and SI and required a shorter duration of treatment.
Mismatch Negativity in Children and Adolescents with Autism Spectrum Disorder
Authors: Mayerle Maria Clara Clack da Silva , Riesgo Rudimar , Gregory Letícia , Borges Viviann Magalhães Silva , Sleifer Pricila 
Published: April 2023

Abstract
Introduction Individuals with autism spectrum disorder (ASD) have abnormalities in auditory perception and sensitivity. The mismatch negativity (MMN) component of the evoked potential demonstrates a brain detection response to an auditory change due to memory, and enables the identification of changes in the auditory system.
Objective To analyze MMN responses in children and adolescents with ASD and compare them with those of a control group.
Methods Cross-sectional and comparative study. The sample was composed of 68 children and adolescents, divided into study group (SG), which contained those diagnosed with ASD, and the control group (CG), which contained those with typical development, normal hearing thresholds, and without hearing complaints. All participants were submitted to peripheral and central electrophysiological auditory evaluations. For the electrophysiological auditory evaluation and MMN recording, the electrodes were fixed in the following positions: Fz (active electrode), M1 and M2 (reference electrodes), and on the forehead (ground electrode). Auditory stimuli were presented in both ears simultaneously, with a frequency of 1,000 Hz for the frequent stimulus, and of 2,000 Hz for the rare stimulus, in an intensity of 80 dBNA.
Results Latency and amplitude values were increased in the SG, with a statistically significant difference in comparison with the CG. In the MMN analysis, there was no statistically significant difference in the comparison between right and left ears and between genders.
Conclusion Children and adolescents with ASD had higher latency and amplitude values in the MMN component than the individuals in the CG.
Integrated macro and micro analyses of student burden reduction policies in China: call for a collaborative “family–school–society” model
Authors: Li Jian , Xue Eryong , Liu Chang , Li Xingcheng 
Published: April 2023

AbstractThe ultimate goal of China’s student burden reduction policy is to promote quality education, which is also the core task of UNESCO’s Sustainable Development Goal for education (SDG 4). China aims to achieve quality education development through continuous implementation of student burden reduction policies. However, no previous studies have simultaneously explored the macro-level dynamic changes and micro-level stakeholders’ (parents) views regarding the implementation of student burden reduction policies. Here, we examined 232 policy documents from 1951 to 2021 and analyzed 23,567 parents’ responses to a questionnaire survey across 29 provinces to obtain holistic insight into student burden reduction policies. We found that student burden reduction policies followed the form “Central leadership + Ministry of Education sovereignty + multi-department coordination”, while parents received relatively little attention. There is a significant correlation between students’ burden level and parents’ attitude towards student burden reduction policies. We suggest building a collaborative “family–school–society” sustainable education system in China.
Psychological Correlates of Self-Rated Resilience in the Context of Subjective Cognitive Concerns in Older Adults
Authors: Donders Jacobus , Wang Qingzheng 
Published: April 2023

Abstract

Objective
The purpose of this study was to evaluate psychological correlates of self-rated resilience, as assessed with the 10-item version of the Connor-Davidson Resilience Scale (CD–RISC–10), in older adults. In particular, we were interested in the degree to which self-rated resilience might be a protective factor against cognitive decline.

Method
In total, 100 adults aged 60–90 years who had been referred because of subjective cognitive concerns completed self-report measures of resilience, symptoms of anxiety and depression, and satisfaction with life. They also completed a test of learning and memory. Ratings about daily functioning at home and in the community were obtained from both participants and proxy informants.

Results
Resilience ratings correlated strongly negatively with concurrent self-rated symptoms of anxiety and depression, and strongly positively with self-rated life satisfaction. However, only informant ratings of daily functioning correlated with actual participant performance on a test of learning and memory, with lower ratings being associated with worse test performance.

Conclusions
Self-rated resilience, as measured by the CD–RISC–10, is primarily related to subjective well-being and does not inform sufficiently about relative risk for cognitive dysfunction in older adults.
The effects of leaving the EU on the geography of UK trade
Authors: Gasiorek Michael , Tamberi Nicolò 
Published: April 2023

Abstract
This paper investigates the effect of the 2016 Brexit referendum and the Trade and Cooperation Agreement (TCA) signed by the United Kingdom and the EU in December 2020 on UK–EU trade in goods up to December 2021. The 2016 referendum introduced uncertainty, but new trade barriers between the United Kingdom and the EU were not put in place until the new agreement, the TCA, entered into force in January 2021. Using a set of different econometric techniques, and looking up to the end of the first year of the implementation of the TCA, we find no evidence that the 2016 referendum had any impact on aggregate UK–EU trade relative to comparator trade flows. On the other hand, our results show that the TCA reduced UK trade with the EU, but asymmetrically for exports and imports. After a sharp drop of around 41% in January 2021, UK exports to the EU quickly recovered in the following months. This pattern of recovery was not the case for UK imports from the EU, which were negatively impacted throughout 2021, with a cumulative loss over the first year of implementation between −24% and −28%. Asymmetric effects between exports and imports do not appear to be driven by difference in product composition of the two flows. Instead, we find evidence that a plausible explanation for these differential effects is the relative importance of the EU market for UK firms, in comparison to the importance of the UK market for EU firms.
Characterization of Staphylococcus aureus RecX protein: Molecular insights into negative regulation of RecA protein and implications in HR processes
Authors: Kiran Kajal , Patil K Neelakanteshwar 
Published: April 2023

Abstract
Homologous recombination (HR) is essential for genome stability and for maintaining genetic diversity. In eubacteria, RecA protein plays a key role during DNA repair, transcription, and HR. RecA is regulated at multiple levels, but majorly by RecX protein. Moreover, studies have shown RecX is a potent inhibitor of RecA and thus acts as an antirecombinase. Staphylococcus aureus is a major food-borne pathogen that causes skin, bone joint, and bloodstream infections. To date, RecX's role in S. aureus has remained enigmatic. Here, we show that S. aureus RecX (SaRecX) is expressed during exposure to DNA-damaging agents, and purified RecX protein directly interacts physically with RecA protein. The SaRecX is competent to bind with single-stranded DNA preferentially and double-stranded DNA feebly. Significantly, SaRecX impedes the RecA-driven displacement loop and inhibits formation of the strand exchange. Notably, SaRecX also abrogates adenosine triphosphate hydrolysis and abolishes the LexA coprotease activity. These findings highlight the role of the RecX protein as an antirecombinase during HR and play a pivotal role in regulation of RecA during the DNA transactions.