bluuebunny/crossref_metadata_2025_split huggingface dataset:
Declines in Peak Snow Water Equivalent and Elevated Snowmelt Rates Following the 2020 Cameron Peak Wildfire in Northern Colorado
Authors: McGrath Daniel , Zeller Lucas , Bonnell Randall , Reis Wyatt , Kampf Stephanie , Williams Keith , Okal Marianne , Olsen‐Mikitowicz Alex , Bump Ella , Sears Megan , Rittger Karl 
Published: March 2023

AbstractWildfires are increasingly impacting high‐elevation forests in the western United States that accumulate seasonal snowpacks, presenting a major disturbance to a critical water reservoir for the region. In the first winter following the 2020 Cameron Peak wildfire in Colorado, the peak snow water equivalent in a high burn severity forest was 17%–25% less than nearby unburned sites. The loss of the forest canopy and a lower surface albedo led to an increasingly positive net shortwave radiation balance in the burned area, resulting in melt rates that were 82%–144% greater than unburned sites and snow disappearance occurred 11–13 days earlier. Late‐season snow storms temporarily buried soot, thus increasing the albedo and delaying melt‐out by an estimated 4 days per storm in our study area. While these storms temporarily reduce the higher melt rates imposed by wildfire impacts, SNOTEL measurements show that they occur non‐uniformly across the western U.S.
Recent Aqueous Activity on Mars Evidenced by Transverse Aeolian Ridges in the Zhurong Exploration Region of Utopia Planitia
Authors: Wang Jiang , Zhao Jiannan , Xiao Long , Peng Shuai , Zhang Liang , Zhang Zhixin , Gao Antong , Qiao He , Wang Le , Zhang Shiqi , Xiao Xiao , Shi Yutong , Zhao Siyuan , Zhao Jiawei , Qian Yuqi , Zhang Jun , Zhang Xubing , Huang Jun 
Published: March 2023

AbstractAqueous activities on Mars have gradually declined since the Noachian (>3.7 Ga). Although water can be stored in the subsurface during the latest epochs, geomorphological evidence is still limited. In this study, we used in situ imaging and spectral data acquired by China's Zhurong rover, as well as high‐resolution remote‐sensing data, to investigate the transverse aeolian ridges (TARs) in the Zhurong landing region of Utopia Planitia. A two‐stage evolutionary scenario of the TARs is proposed and polygonal features with hydrated minerals are identified for the first time on the surface of Martian TARs. We discussed the possible formation mechanisms of the polygonal features, and proposed that they could be related to recent aqueous activity and atmosphere‐surface water exchange on Mars, which sheds light on the hydrological cycle of Mars in current cold and dry climate.
Impact of Tropospheric Ozone Modulation Due To El Niño on Tides in the MLT
Authors: Kogure Masaru , Liu Huixin , Jin Hidekatsu 
Published: March 2023

AbstractTo assess the impacts of the tropospheric ozone modulation due to El Niño on tides, we performed two simulations by using the Ground‐to‐topside Atmosphere Ionosphere model for Aeronomy model: zonally symmetric ozone density and longitudinal ozone variation of an El Niño pattern. Our results show that the ozone modulation strengthens (attenuates) the first symmetric mode of the DW2 (D0 and DW1) tide by ∼+5% (∼−1% and ∼−4%) from ∼20 to ∼100 km altitudes on average. These responses are probably attributed to the tropospheric ozone modulation. These responses are reasonable because both the ozone modulation and these first modes have a peak at the equator. Also, the vertical wavelengths of the first modes are about twice as long as the vertical thickness of the ozone modulation. Our results suggest that the ozone modulation due to El Niño influences the diurnal tides by a few percent because of the ozone modulation spatial structure.
The p52-ZER6/G6PD axis alters aerobic glycolysis and promotes tumor progression by activating the pentose phosphate pathway
Authors: Tang Yu , Li Wenfang , Qiu Li , Zhang Xia , Zhang Lei , Miyagishi Makoto , Zhao Hezhao , Wu Shourong , Kasim Vivi 
Published: March 2023

AbstractAbnormal glucose metabolism is a highlight of tumor metabolic reprogramming and is closely related to the development of malignancies. p52-ZER6, a C2H2-type zinc finger protein, promotes cell proliferation and tumorigenesis. However, its role in the regulation of biological and pathological functions remains poorly understood. Here, we examined the role of p52-ZER6 in tumor cell metabolic reprogramming. Specifically, we demonstrated that p52-ZER6 promotes tumor glucose metabolic reprogramming by positively regulating the transcription of glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway (PPP). By activating the PPP, p52-ZER6 was found to enhance the production of nucleotides and nicotinamide adenine dinucleotide phosphate, thereby providing tumor cells with the building blocks of ribonucleic acids and cellular reductants for reactive oxygen species scavenging, which subsequently promotes tumor cell proliferation and viability. Importantly, p52-ZER6 promoted PPP-mediated tumorigenesis in a p53-independent manner. Taken together, these findings reveal a novel role for p52-ZER6 in regulating G6PD transcription via a p53-independent process, ultimately resulting in tumor cell metabolic reprogramming and tumorigenesis. Our results suggest that p52-ZER6 is a potential target for the diagnosis and treatment of tumors and metabolic disorders.
P2X3 receptor antagonism attenuates the progression of heart failure
Authors: Lataro Renata M. , Moraes Davi J. A. , Gava Fabio N. , Omoto Ana C. M. , Silva Carlos A. A. , Brognara Fernanda , Alflen Lais , Brazão Vânia , Colato Rafaela Pravato , do Prado José Clóvis , Ford Anthony P. , Salgado Helio C. , Paton Julian F. R. 
Published: March 2023

AbstractDespite advances in the treatment of heart failure, prognosis is poor, mortality high and there remains no cure. Heart failure is associated with reduced cardiac pump function, autonomic dysregulation, systemic inflammation and sleep-disordered breathing; these morbidities are exacerbated by peripheral chemoreceptor dysfunction. We reveal that in heart failure the carotid body generates spontaneous, episodic burst discharges coincident with the onset of disordered breathing in male rats. Purinergic (P2X3) receptors were upregulated two-fold in peripheral chemosensory afferents in heart failure, and when antagonized abolished these episodic discharges, normalized both peripheral chemoreceptor sensitivity and the breathing pattern, reinstated autonomic balance, improved cardiac function, and reduced both inflammation and biomarkers of cardiac failure. Aberrant ATP transmission in the carotid body triggers episodic discharges that via P2X3 receptors play a crucial role in the progression of heart failure and as such offer a distinct therapeutic angle to reverse multiple components of its pathogenesis.
Anthropogenic impacts on threatened species erode functional diversity in chelonians and crocodilians
Authors: Rodríguez-Caro R. C. , Graciá E. , Blomberg S. P. , Cayuela H. , Grace M. , Carmona C. P. , Pérez-Mendoza H. A. , Giménez A. , Salguero-Gómez R. 
Published: March 2023

AbstractThe Anthropocene is tightly associated with a drastic loss of species worldwide and the disappearance of their key ecosystem functions. The orders Testudines (turtles and tortoises) and Crocodilia (crocodiles, alligators, and gharials) contain numerous threatened, long-lived species for which the functional diversity and potential erosion by anthropogenic impacts remains unknown. Here, we examine 259 (69%) of the existing 375 species of Testudines and Crocodilia, quantifying their life history strategies (i.e., trade-offs in survival, development, and reproduction) from open-access data on demography, ancestry, and threats. We find that the loss of functional diversity in simulated extinction scenarios of threatened species is greater than expected by chance. Moreover, the effects of unsustainable local consumption, diseases, and pollution are associated with life history strategies. In contrast, climate change, habitat disturbance, and global trade affect species independent of their life history strategy. Importantly, the loss of functional diversity for threatened species by habitat degradation is twice that for all other threats. Our findings highlight the importance of conservation programmes focused on preserving the functional diversity of life history strategies jointly with the phylogenetic representativity of these highly threatened groups.
Controlling single rare earth ion emission in an electro-optical nanocavity
Authors: Yang Likai , Wang Sihao , Shen Mohan , Xie Jiacheng , Tang Hong X. 
Published: March 2023

AbstractRare earth emitters enable critical quantum resources including spin qubits, single photon sources, and quantum memories. Yet, probing of single ions remains challenging due to low emission rate of their intra-4f optical transitions. One feasible approach is through Purcell-enhanced emission in optical cavities. The ability to modulate cavity-ion coupling in real-time will further elevate the capacity of such systems. Here, we demonstrate direct control of single ion emission by embedding erbium dopants in an electro-optically active photonic crystal cavity patterned from thin-film lithium niobate. Purcell factor over 170 enables single ion detection, which is verified by second-order autocorrelation measurement. Dynamic control of emission rate is realized by leveraging electro-optic tuning of resonance frequency. Using this feature, storage, and retrieval of single ion excitation is further demonstrated, without perturbing the emission characteristics. These results promise new opportunities for controllable single-photon sources and efficient spin-photon interfaces.
Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production
Authors: Kajiwara-Kubota Mariko , Uchiyama Kazuhiko , Asaeda Kohei , Kobayashi Reo , Hashimoto Hikaru , Yasuda Takeshi , Sugino Satoshi , Sugaya Takeshi , Hirai Yasuko , Mizushima Katsura , Doi Toshifumi , Inoue Ken , Dohi Osamu , Yoshida Naohisa , Ishikawa Takeshi , Takagi Tomohisa , Konishi Hideyuki , Inoue Ryo , Itoh Yoshito , Naito Yuji 
Published: March 2023

AbstractColonic mucus layers protect intestinal tissues against intestinal bacteria. We investigated the effects of dietary fiber and its metabolites on mucus production in the colonic mucosa. Mice were fed a partially hydrolyzed guar gum (PHGG)-containing diet and a fiber-free diet (FFD). The colon mucus layer, fecal short-chain fatty acid (SCFA) levels, and gut microbiota were evaluated. Mucin 2 (MUC2) expression was assessed in SCFA-treated LS174T cells. The role of AKT in MUC2 production was investigated. The mucus layer in the colonic epithelium was significantly increased in the PHGG group compared with that in the FFD group. In the PHGG group, an increase in Bacteroidetes in the stool was observed, and fecal acetate, butyrate, propionate, and succinate levels were significantly increased. However, MUC2 production was significantly increased only in succinate-stimulated LS174T cells. The succinate-induced MUC2 production was associated with AKT phosphorylation. Succinate mediated the PHGG-induced increase in the colon mucus layer.
Progress towards a glycoconjugate vaccine against Group A Streptococcus
Authors: Burns Keira , Dorfmueller Helge C. , Wren Brendan W. , Mawas Fatme , Shaw Helen A. 
Published: March 2023

AbstractThe Group A Carbohydrate (GAC) is a defining feature of Group A Streptococcus (Strep A) orStreptococcus pyogenes. It is a conserved and simple polysaccharide, comprising a rhamnose backbone and GlcNAc side chains, further decorated with glycerol phosphate on approximately 40% GlcNAc residues. Its conservation, surface exposure and antigenicity have made it an interesting focus on Strep A vaccine design. Glycoconjugates containing this conserved carbohydrate should be a key approach towards the successful mission to build a universal Strep A vaccine candidate. In this review, a brief introduction to GAC, the main carbohydrate component of Strep A bacteria, and a variety of published carrier proteins and conjugation technologies are discussed. Components and technologies should be chosen carefully for building affordable Strep A vaccine candidates, particularly for low- and middle-income countries (LMICs). Towards this, novel technologies are discussed, such as the prospective use of bioconjugation with PglB for rhamnose polymer conjugation and generalised modules for membrane antigens (GMMA), particularly as low-cost solutions to vaccine production. Rational design of “double-hit” conjugates encompassing species specific glycan and protein components would be beneficial and production of a conserved vaccine to target Strep A colonisation without invoking an autoimmune response would be ideal.
Emotion regulation and virtual nature: cognitive reappraisal as an individual-level moderator for impacts on subjective vitality
Authors: Theodorou Annalisa , Spano Giuseppina , Bratman Gregory N. , Monneron Kevin , Sanesi Giovanni , Carrus Giuseppe , Imperatori Claudio , Panno Angelo 
Published: March 2023

AbstractPeople who make habitual use of an emotion regulation strategy such as cognitive reappraisal may be more sensitive to the emotion cues coming from a surrounding natural environment and, thus, get more benefits from virtual nature exposure such as enhanced subjective vitality. However, no previous study investigated the moderating role of cognitive reappraisal in the relationship between exposure to different types of natural environments (a national park, a lacustrine environment, and an arctic environment vs. an urban environment) and subjective vitality. We designed a between-subject design (four conditions, one per type of environment) with a sample of 187 university students (Mage = 21.17, SD = 2.55). Participants were exposed to four 360° panoramic photos of the environment for one minute each with a virtual reality head-mounted display. The results of a multicategorical moderation analysis attested that there were two significant interactions, respectively between lacustrine and arctic environments and cognitive reappraisal. More specifically, for participants with low levels of habitual use of cognitive reappraisal, the effects of virtual nature (vs. urban) exposure on subjective vitality were not significant, while for participants with high levels, the effects were significant and positive. Findings show how the potential of virtual nature may be boosted with training aimed at increasing the general use of cognitive reappraisal, supports enhancing the applications of virtual nature, and demonstrates the need to take individual differences into account when determining the benefits of these applications.
Physicochemical and thermomechanical performances study for Timahdite sheep wool fibers application in the building's insulation
Authors: Atbir Aziza , Taibi Mhamed , Aouan Badr , Khabbazi Abdelhamid , Ansari Omar , Cherkaoui Moha , Cherradi Toufik 
Published: March 2023

AbstractThe present research focuses on the development and thermomechanical characterization of unfired solid bricks based on clay (white and red) and Timahdite sheep wool, which are local, durable, abundant, and economical materials. As this clay material is incorporated with sheep wool in the form of yarn multi-layers in opposite directions. It achieves good thermal and mechanical performance and a lightness of these bricks as acquired progress. This new method of reinforcement offers significant thermo-mechanical performance for the composite for thermal insulation in sustainable buildings. Several physicochemical analyses to characterize the raw materials were used. Thermomechanical measurements to characterize the elaborated materials. The wool yarn effect was significant on the mechanical behavior of the developed materials at 90 days, with flexural strength from 18 to 56% for the white clay. And 8–29% for the red one. Decrease in compressive strength from 9 to 36% for the white clay and 5–18% for the red one. These mechanical performances are accompanied by thermal conductivity gain ranging from 4 to 41% for the white and 6–39% for the red for wool fractions: 6–27 g. This green multi-layered bricks from abundant local materials with optimal thermo-mechanical properties, qualified for the intended use for thermal insulation and energy efficiency in the construction and development of local economies.
Vascular parameters and endothelin-1 measurements in glaucoma patients with low- and high-tension optic disc hemorrhages
Authors: Almeida Izabela N. F. , Taniguchi Elise , Tito Cecília Victoria Agapito , Dias Diego Torres , Ushida Michele , Dorairaj Syril , Ritch Robert , Teixeira Sérgio H. , Paranhos Augusto , Gracitelli Carolina P. B. , Kayser Cristiane , Prata Tiago Santos 
Published: March 2023

AbstractThis prospective study aimed to compare vascular parameters (endothelin-1 [ET-1] blood levels, laser Doppler imaging [LDI] of distal phalanxes, and nailfold capillaroscopy) between open-angle glaucoma patients with low- and high-tension optic disc hemorrhages (LTDH and HTDH, respectively). The 33 enrolled patients (mean age, 62.3 ± 13 years) were classified as LTDH or HTDH if they presented at the time of DH detection an intraocular pressure (IOP) < 16 mmHg or ≥ 16 mmHg, respectively. Demographic and ophthalmological data, ET-1 concentrations, LDI (before and 1, 10, and 20 min after cold stimulation), and nailfold capillaroscopy findings were evaluated. The ET-1 blood level was 65% higher in the LTDH (2.27 ± 1.46 pg/ml) than in the HTDH (1.37 ± 0.57 pg/ml; p = 0.03) group. Moreover, there was a statistically significant negative correlation between ET-1 blood concentration and IOP at the time of DH detection (r = −0.45, p = 0.02). Blood flow measurements 10 and 20 min after cold stimulation were lower in the LTDH group than in the HTDH group (p < 0.01). Patients developing DH with lower IOPs have higher ET-1 blood levels and more peripheral vascular dysfunction as estimated by LDI than those with higher IOPs. These findings suggest that distinct underlying mechanisms may be involved in patients developing DH within different IOP ranges.
Fluctuating sea-level and reversing Monsoon winds drive Holocene lagoon infill in Southeast Asia
Authors: Kappelmann Yannis , Westphal Hildegard , Kneer Dominik , Wu Henry C. , Wizemann André , Jompa Jamaluddin , Mann Thomas 
Published: March 2023

AbstractMany lagoons surrounded by reefs are partially or completely infilled with reef-derived detrital carbonate sediment. Sediment deposits in such restricted environments are archives of prevailing environmental conditions during lagoon infill. For Indonesia, no paleoenvironmental reconstructions based on Holocene lagoon sediments exist. Here we analyze the sedimentary record obtained from five percussion cores penetrating 10 m into the unconsolidated subsurface of a reef island in the Spermonde Archipelago, Indonesia. The combined compositional, textural and chronostratigraphic analyses reveal that the sedimentary infill of the lagoon underlying the island, starting 6900 years cal BP, was interrupted between 5800 and 4400 years cal BP, when sea level was ~ 0.5 m higher than at present, and monsoon intensity was lower. After the intensity of the monsoons increased to modern levels, and sea level dropped to its present position, lagoonal sedimentation was re-initiated and created the foundation for an island that built up since 3000 years cal BP. Our study provides the first geological evidence for the strong sensitivity of detrital carbonate systems in Indonesia to fluctuations in sea level and dominant wind direction. It thus sheds light on how changing environmental conditions in the context of global warming could affect the morphological development of reef systems, and thereby also habitable coastal areas.
Adapting to visuomotor rotations in stepped increments increases implicit motor learning
Authors: Modchalingam Shanaathanan , Ciccone Marco , D’Amario Sebastian , ’t Hart Bernard Marius , Henriques Denise Y. P. 
Published: March 2023

AbstractHuman motor adaptation relies on both explicit conscious strategies and implicit unconscious updating of internal models to correct motor errors. Implicit adaptation is powerful, requiring less preparation time before executing adapted movements, but recent work suggests it is limited to some absolute magnitude regardless of the size of a visuomotor perturbation when the perturbation is introduced abruptly. It is commonly assumed that gradually introducing a perturbation should lead to improved implicit learning beyond this limit, but outcomes are conflicting. We tested whether introducing a perturbation in two distinct gradual methods can overcome the apparent limit and explain past conflicting findings. We found that gradually introducing a perturbation in a stepped manner, where participants were given time to adapt to each partial step before being introduced to a larger partial step, led to ~ 80% higher implicit aftereffects of learning, but introducing it in a ramped manner, where participants adapted larger rotations on each subsequent reach, did not. Our results clearly show that gradual introduction of a perturbation can lead to substantially larger implicit adaptation, as well as identify the type of introduction that is necessary to do so.
Dynamics of chaotic system based on circuit design with Ulam stability through fractal-fractional derivative with power law kernel
Authors: Khan Naveed , Ahmad Zubair , Shah Jamal , Murtaza Saqib , Albalwi M. Daher , Ahmad Hijaz , Baili Jamel , Yao Shao-Wen 
Published: March 2023

AbstractIn this paper, the newly developed Fractal-Fractional derivative with power law kernel is used to analyse the dynamics of chaotic system based on a circuit design. The problem is modelled in terms of classical order nonlinear, coupled ordinary differential equations which is then generalized through Fractal-Fractional derivative with power law kernel. Furthermore, several theoretical analyses such as model equilibria, existence, uniqueness, and Ulam stability of the system have been calculated. The highly non-linear fractal-fractional order system is then analyzed through a numerical technique using the MATLAB software. The graphical solutions are portrayed in two dimensional graphs and three dimensional phase portraits and explained in detail in the discussion section while some concluding remarks have been drawn from the current study. It is worth noting that fractal-fractional differential operators can fastly converge the dynamics of chaotic system to its static equilibrium by adjusting the fractal and fractional parameters.