bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis de la percepción de un grupo de jóvenes adultas que ha padecido un Trastorno de la Conducta Alimentaria sobre los contenidos acerca de salud mental en las Redes Sociales Virtuales
Authors: Calmaestra Urbano Sara Montserrat 
Published: June 2023

Aunque se habla a menudo de los efectos adversos de las Redes Sociales Virtuales (RRSSVV) en la salud mental de los y las jóvenes, algunos autores también han señalado que estas pueden ser interesantes herramientas en la promoción y mejora de la salud mental. Se ha encontrado que las RRSSVV son medios de información rápidos y eficientes y que facilitan y favorecen el soporte social facilitando la comunicación. El objetivo de este estudio fue analizar la percepción que tienen un grupo de jóvenes adultas que habían padecido un Trastorno de la Conducta Alimentaria (TCA) sobre el impacto de las RRSSVV en la salud mental. Para ello, se llevó a cabo un estudio fenomenológico basado en un análisis temático. La herramienta utilizada para ello fue un grupo focal conformado por 5 mujeres de entre 23 y 26 años de edad que habían padecido un TCA en el que se recogió la opinión que tienen acerca de aspectos como el impacto de los contenidos sobre salud mental en RRSSVV, la valoración que hacen de poder contactar con personas que padecen un trastorno como el suyo o la valoración que hacen de que personas públicas hablen sobre sus trastornos de salud mental en RRSSVV, entre otros. Por lo que respecta a los hallazgos, en líneas generales las participantes se mostraron bastante críticas, sobre todo con lo que respecta a la falta de profesionalidad entre las personas que publican este tipo de contenidos y la falta de control entre las personas que los consumen. Por otro lado, valoraron muy positivamente que personas públicas hablen en primera persona sobre sus problemas de salud mental, cosa que ayudaría a desestigmatizar estos problemas y empoderar a las jóvenes a pedir ayuda profesional. En conclusión, las RRSSVV podrían ser una buena herramienta, pero sería necesario integrar algunas mejoras, como la formación y capacitación de los y las creadores de contenido que hablan de salud mental.
SENTIMENT ANALYSIS FOR PHARMACEUTICAL COMPANY FROM SOCIAL MEDIA USING ADAPTIVE COMPRESSION (ADACOMP) WITH RANDOM UNDER SAMPLE (RUS) AND SYNTHETIC MINORITY OVER-SAMPLING (SMOTE)
Authors: Wibowo Pamungkas Setyo , Chowanda Andry 
Published: June 2023

Pharmaceutical company has become the most highlight company across the world lately because of the pandemic. Despite of the high demand market in pharmaceutical company, about 94% of large company across the world having difficulty in their supply chain that indirectly affect their services. The purpose of this research is to compare word embedding with compression model by doing sentiment analysis about the entity to find the best model that give better accuracy rates based on the opinion of Twitter, Instagram and Youtube, as they are the largest platform that its many users to express their opinions about an individual or an instance. Data is retrieved from Twitter, Instagram and Youtube using the R-Studio application by utilizing their API library, then preprocessing and stored in a database. Next step is labeling the data and then train the data using word2Vec and LSTM, GloVe and LSTM and lastly using Adaptive Compression (adaComp) to compress the both model word embedding. Unfortunately, we got imbalanced dataset after labeling process, so we add sampling technique to sampling the dataset using Random Under Sample (RUS) and Synthetic Minority Over-sampling Technique (SMOTE). After the data are trained and tested, the results will be evaluated using Confusion Matrix to get the best Accuracy. With several models that have been carried out,applying adaComp is proven to increase accuracy. In the Word2Vec word embedding with LSTM model, applying adaComp increasing its accuracy from 77% to 81%.
Diseminasi Alat Pengirat Bambu ke Pengrajin Bambu di Desa Radamata, Sumba Barat Daya
Authors: Salman - , Sugiman - , Setyawan Paryanto Dwi , Sinarep - , Sayoga I Made Adi 
Published: June 2023

Pemanfaatan bambu seyogyanya menciptakan peluang nilai tambah yang lebih tinggi untuk meningkatkan pendapatan masyarakat. Perlu dilakukan sinergitas program-program pemerintah lintas sektor untuk dapat mewujudkan pengembangan bambu yang terintegrasi sehingga menjadikan bambu sebagai penggerak ekonomi rakyat. Karena itulah dengan tujuan untuk mengoptimalkan potensi pengembangan pengolahan bambu di daerah tertinggal, maka tim pelaksana peningkatan kapasitas tenaga kerja non pertanian melakukan diseminasi alat pengirat bambu di di Sumba Barat Daya, Nusa Tenggara Timur. Kegiatan diawali dengan pembuatan alat pengirat bambu. melalui tahap perancangan sebelumnya dari tim LPPM Unram. Selanjutnya alat di-diseminasi ke pengrajin bambu di Sumba Barat Daya. Hasil dari kegiatan adalah adanya sikap antusiasme dari para pengrajin dan adanya alat pengirat bambu pada pengrajin setempat.
Bisphenol A and di-ethylhexyl phthalate analysis in gallon water distributed in Makassar
Authors: Endah Dwijayanti  , Rachim Munadi  , Sry Wahyuningsih  , Iffana Dani Maulida  
Published: June 2023

Bisphenol A (BPA) and Di-Ethylhexyl Phthalate (DEHP) are chemical compounds that are used as raw materials for making disposable bottles or PET, including gallons. BPA can migrate into food or drink if the temperature is raised due to heating processes. This research aimed to identify BPA and DEHP compounds in various brands of gallon water distributed in Makassar and the effect of sun exposure towards BPA and DEHP migration. The sampling method was done based on an early analysis from field survey data in the location that represents all gallon water refills distributed in Makassar. There were 4 selected samples from 2 most marketed brands of gallon water refill. Research method included sample preparation with two different treatments, namely with exposure and without exposure to sunlight by letting them settle inside and outside the room for 6 days, afterwards, BPA and DEHP were analyzed using Gas Chromatography - Mass Spectrometry (GC-MS). The results of the study show that in various brands gallon water packages, both with sun exposure or without, no BPA and DEHP compounds were detected.
STRATEGI PENGEMBANGAN USAHA KECIL MENENGAH (UKM) PENGOLAHAN IKAN ASAP YANG BERORIENTASI PASAR DI KABUPATEN BONE
Authors: Ohorella Rafi , Mulyono S. Baskoro  , Sri Harijati  
Published: June 2023

This study aims to examine the conditions of, and formulate a strategy for, developing smoked fish processing in small and medium enterprises (SMEs) in Bone Regency. Methods of data collection include interviews, field observations, and documentation with questionnaires. Method of data analysis include descriptive analysis of the conditions and characteristics of smoked fish processing SMEs, SWOT (Strength-Weakness-Opportunities-Threat) analysis and QSPM (Quantitative Strategic Planning Matrix) methods to formulate priority strategies for developing smoked fish processing SMEs. The results show the following conditions of smoked fish processing in Bone Regency: 100% of the SMEs use simple technologies, 79% have low education, 91.94% of the workforce was of productive age. The SMEs development strategies that can be learned include strategies for establishing cooperative relationships and government support in promoting smoked fish processed products, strategies for developing smoked fish processing SMEs with training and counseling programs from relevant agencies, strategies for implementing the latest processing technological innovations by renewing infrastructures of facilities, as well as strategies for completing business permits and legalities.Penelitian ini bertujuan untuk mengkaji kondisi dan merumuskan strategi pengembangan Usaha Kecil dan Menengah (UKM) pengolahan ikan asap di Kabupaten Bone. Pengumpulan data dilakukan dengan wawancara, observasi lapangan, dan dokumentasi dengan kuesioner sebagai alat bantu. Analisis dilakukan secara deskriptif terhadap kondisi dan karakteristik UKM pengolah ikan asap. Analisis iSWOT dan metode QSPM untuk merumuskan prioritas strategi pengembangan UKM pengolahan ikan asap. Hasil penelitian menunjukan bahwa kondisi pengolah ikan asap di Kabupaten Bone 100% menggunakan teknologi sederhana, 79% memiliki pendidikan rendah, serta umur tenaga kerja produktif sebanyak 91,94% dan strategi pengembangan UKM yang dapat di ambil adalah strategi menjalin hubungan kerjasama dan dukungan pemerintah dalam mempromosikan produk olahan ikan asap, strategi peningkatan/pengembangan UKM pengolahan ikan asap dengan program pelatihan dan penyuluhan dari dinas terkait, strategi penerapan inovasi-inovasi teknologi pengolahan terkini dengan pembaharuan sarana prasarana, serta strategi penyelesaian perizinan dan legalitas usaha.
Maternal and paternal tuberculosis is associated with increased asthma and respiratory symptoms in their offspring: a study from Northern Europe
Authors: Gyawali Sanjay , López-Cervantes Juan Pablo , Johannessen Ane , Gislason Thorarinn , Holm Mathias , Janson Christer , Jögi Rain , Modig Lars , Schlünssen Vivi , Mustafa Tehmina , Svanes Cecilie 
Published: June 2023

BackgroundGiven the profound impact of tuberculosis (TB) on immunity and given murine studies suggesting that infections may influence immunity across generations, we hypothesize that parental TB might impact health and disease in future offspring.ObjectiveThis study investigated the impact of maternal and paternal TB on offspring asthma and respiratory symptoms.MethodsWe included data from the third follow-up of the Respiratory Health in Northern Europe study (RHINE). Information on own asthma status, asthma-like symptoms and other respiratory symptoms, as well as information about parental TB and asthma, were collected using standardized questionnaires. The associations between parental TB and RHINE participants' asthma and respiratory symptoms were analyzed using multiple logistic regression, with adjustment for parental education, smoking habits and asthma.ResultsOf 8,323 study participants, 227 (2.7%) reported only paternal TB, 282 (3.4%) only maternal TB, and 33 (0.4%) reported that both parents had TB. We found a higher risk of asthma (aOR: 1.29, 95% CI: 1.05–1.57) in offspring with a history of parental TB as compared to offspring without parental TB., Parental TB was significantly associated with allergic asthma in offspring (aOR: 1.58, 95% CI: 1.29–2.05), while no significant association between parental TB and asthma without allergy (aOR: 1.00, 95% CI: 0.76–1.32) in offspring was observed.ConclusionResults from this study indicate that parental TB might be a risk factor for offspring's asthma and respiratory symptoms. We raise the hypothesis that the immunological impact of infections might be transmitted to influence offspring phenotype in humans.
Genetically predicted hypertension, antihypertensive drugs, and risk of erectile dysfunction: a Mendelian randomization study
Authors: Zhao Cong , Feng Jun-long , Deng Sheng , Wang Xiang-peng , Fu Yu-jie , Wang Bin , Li Hai-song , Meng Fan-chao , Wang Ji-sheng , Wang Xian 
Published: June 2023

BackgroundThe causal relationship between hypertension, antihypertensive drugs and the risk of erectile dysfunction is still uncertain. We performed a univariable and multivariable Mendelian randomization study to investigate whether they are causally related to erectile dysfunction.MethodsGenetic variants associated with blood pressure were derived from the genome-wide association study meta-analysis of the UK Biobank and International Consortium of Blood Pressure (N = 757,601). Summary association data for hypertension were obtained from the UK Biobank (N = 463,010) and the FinnGen study (N = 356,077). The summary statistics of erectile dysfunction were obtained from the European ancestry with 223,805 subjects. The SNP instruments used to assess the effect of the protein targets of antihypertensive drugs on erectile dysfunction were obtained from previous studys. Causal effects were estimated using the univariate Mendelian randomization method (inverse variance weighted, MR-Egger, weighted median, MR-PRESSO and Wald ratios) and the multivariate Mendelian randomization method. Sensitivity analyses were implemented with the Cochran's Q-test, MR-Egger intercept test, MR-PRESSO, and leave-one-out analysis.ResultsUnivariate MR found that elevated diastolic blood pressure may increase the occurrence of erectile dysfunction (odds ratio [OR] = 1.012; 95% confidence interval [CI]: 1.000–1.024; P = 0.047). Genetically predicted hypertension is also associated with ED (For the FinnGen, OR = 1.106; 95% CI: 1.027–1.191; P = 0.008. For the UK Biobank, OR = 3.832; 95% CI: 1.410–10.414; P = 0.008). However, after adjusting for systolic blood pressure, diastolic blood pressure and hypertension using multivariate Mendelian randomization, only hypertension was causally associated with ED occurrence (For the FinnGen, OR = 1.103; 95% CI: 1.018–1.195; P = 0.017. For the UK Biobank, OR = 5.037; 95% CI: 1.601–15.846; P = 0.006). We found no evidence that the use of angiotensin-converting enzyme inhibitors, beta-blockers, calcium channel blockers, and thiazide diuretic increased the risk of erectile dysfunction.ConclusionsGenetically predicted hypertension increases the risk of erectile dysfunction, but we found no causal relationship between elevated systolic/diastolic blood pressure and erectile dysfunction. We speculate that the relationship between elevated blood pressure and erectile dysfunction risk may be nonlinear. We found little evidence that antihypertensive drugs increase the risk of erectile dysfunction.
Proglacial river stage derived from georectified time-lapse camera images, Inglefield Land, Northwest Greenland
Authors: Goldstein Seth N. , Ryan Jonathan C. , How Penelope R. , Esenther Sarah E. , Pitcher Lincoln H. , LeWinter Adam L. , Overstreet Brandon T. , Kyzivat Ethan D. , Fayne Jessica V. , Smith Laurence C. 
Published: June 2023

The Greenland Ice Sheet is a leading source of global sea level rise, due to surface meltwater runoff and glacier calving. However, given a scarcity of proglacial river gauge measurements, ice sheet runoff remains poorly quantified. This lack of in situ observations is particularly acute in Northwest Greenland, a remote area releasing significant runoff and where traditional river gauging is exceptionally challenging. Here, we demonstrate that georectified time-lapse camera images accurately retrieve stage fluctuations of the proglacial Minturn River, Inglefield Land, over a 3 year study period. Camera images discern the river’s wetted shoreline position, and a terrestrial LiDAR scanner (TLS) scan of riverbank microtopography enables georectification of these positions to vertical estimates of river stage. This non-contact approach captures seasonal, diurnal, and episodic runoff draining a large (∼2,800 km2) lobe of grounded ice at Inglefield Land with good accuracy relative to traditional in situ bubble-gauge measurements (r2 = 0.81, Root Mean Square Error (RMSE) ±0.185 m for image collection at 3-h frequency; r2 = 0.92, RMSE ±0.109 m for resampled average daily frequency). Furthermore, camera images effectively supplement other instrument data gaps during icy and/or low flow conditions, which challenge bubble-gauges and other contact-based instruments. This benefit alone extends the effective seasonal hydrological monitoring period by ∼2–4 weeks each year for the Minturn River. We conclude that low-cost, non-contact time-lapse camera methods offer good promise for monitoring proglacial meltwater runoff from the Greenland Ice Sheet and other harsh polar environments.
Efficacy of dehydroepiandrosterone priming in women with poor ovarian response undergoing IVF/ICSI: a meta-analysis
Authors: Zhang Jie , Jia Hongyan , Diao Feiyang , Ma Xiang , Liu Jiayin , Cui Yugui 
Published: June 2023

BackgroundDehydroepiandrosterone (DHEA) may improve the outcomes of patients with poor ovarian response (POR) or diminished ovarian reserve (DOR) undergoing IVF/ICSI. However, the evidence remains inconsistent. This study aimed to investigate the efficacy of DHEA supplementation in patients with POR/DOR undergoing IVF/ICSI.MethodsPubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) were searched up to October 2022.ResultsA total of 32 studies were retrieved, including 14 RCTs, 11 self-controlled studies and 7 case-controlled studies. In the subgroup analysis of only RCTs, DHEA treatment significantly increased the number of antral follicle count (AFC) (weighted mean difference : WMD 1.18, 95% confidence interval(CI): 0.17 to 2.19, P=0.022), while reduced the level of bFSH (WMD -1.99, 95% CI: -2.52 to -1.46, P&lt;0.001), the need of gonadotropin (Gn) doses (WMD -382.29, 95% CI: -644.82 to -119.76, P=0.004), the days of stimulation (WMD -0.90, 95% CI: -1.34 to -0.47, P &lt;0.001) and miscarriage rate (relative risk : RR 0.46, 95% CI: 0.29 to 0.73, P=0.001). The higher clinical pregnancy and live birth rates were found in the analysis of non-RCTs. However, there were no significant differences in the number of retrieved oocytes, the number of transferred embryos, and the clinical pregnancy and live birth rates in the subgroup analysis of only RCTs. Moreover, meta-regression analyses showed that women with lower basal FSH had more increase in serum FSH levels (b=-0.94, 95% CI: -1.62 to -0.25, P=0.014), and women with higher baseline AMH levels had more increase in serum AMH levels (b=-0.60, 95% CI: -1.15 to -0.06, P=0.035) after DHEA supplementation. In addition, the number of retrieved oocytes was higher in the studies on relatively younger women (b=-0.21, 95% CI: -0.39 to -0.03, P=0.023) and small sample sizes (b=-0.003, 95% CI: -0.006 to -0.0003, P=0.032).ConclusionsDHEA treatment didn’t significantly improve the live birth rate of women with DOR or POR undergoing IVF/ICSI in the subgroup analysis of only RCTs. The higher clinical pregnancy and live birth rates in those non-RCTs should be interpreted with caution because of potential bias. Further studies using more explicit criteria to subjects are needed.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD 42022384393.
Integrated multi-omics analyses reveal the altered transcriptomic characteristics of pulmonary macrophages in immunocompromised hosts with Pneumocystis pneumonia
Authors: Wang Yawen , Li Kang , Zhao Weichao , Liu Yalan , Li Ting , Yang Hu-Qin , Tong Zhaohui , Song Nan 
Published: June 2023

IntroductionWith the extensive use of immunosuppressants, immunosuppression-associated pneumonitis including Pneumocystis jirovecii pneumonia (PCP) has received increasing attention. Though aberrant adaptive immunity has been considered as a key reason for opportunistic infections, the characteristics of innate immunity in these immunocompromised hosts remain unclear.MethodsIn this study, wild type C57BL/6 mice or dexamethasone-treated mice were injected with or without Pneumocystis. Bronchoalveolar lavage fluids (BALFs) were harvested for the multiplex cytokine and metabolomics analysis. The single-cell RNA sequencing (scRNA-seq) of indicated lung tissues or BALFs was performed to decipher the macrophages heterogeneity. Mice lung tissues were further analyzed via quantitative polymerase chain reaction (qPCR) or immunohistochemical staining.ResultsWe found that the secretion of both pro-inflammatory cytokines and metabolites in the Pneumocystis-infected mice are impaired by glucocorticoids. By scRNA-seq, we identified seven subpopulations of macrophages in mice lung tissues. Among them, a group of Mmp12+ macrophages is enriched in the immunocompetent mice with Pneumocystis infection. Pseudotime trajectory showed that these Mmp12+ macrophages are differentiated from Ly6c+ classical monocytes, and highly express pro-inflammatory cytokines elevated in BALFs of Pneumocystis-infected mice. In vitro, we confirmed that dexamethasone impairs the expression of Lif, Il1b, Il6 and Tnf, as well as the fungal killing capacity of alveolar macrophage (AM)-like cells. Moreover, in patients with PCP, we found a group of macrophages resembled the aforementioned Mmp12+ macrophages, and these macrophages are inhibited in the patient receiving glucocorticoid treatment. Additionally, dexamethasone simultaneously impaired the functional integrity of resident AMs and downregulated the level of lysophosphatidylcholine, leading to the suppressed antifungal capacities.ConclusionWe reported a group of Mmp12+ macrophages conferring protection during Pneumocystis infection, which can be dampened by glucocorticoids. This study provides multiple resources for understanding the heterogeneity and metabolic changes of innate immunity in immunocompromised hosts, and also suggests that the loss of Mmp12+ macrophages population contributes to the pathogenesis of immunosuppression-associated pneumonitis.
Efficacy and safety of programmed cell death receptor 1 inhibition-based regimens in patients with pediatric malignancies: the real-world study in China
Authors: Hong Ye , Song Mengjia , Lan Yingxia , Wang Juan , Lu Suying , Zhang Yu , Zhu Jia , Sun Feifei , Huang Junting , Liu Juan , Xu Jiaqian , Wu Yanpeng , Guo Haixia , Cai Ruiqing , Zhen Zijun , Que Yi , Zhang Yizhuo 
Published: June 2023

BackgroundProgrammed death receptor 1 (PD-1) inhibition has shown durable response and mild adverse events (AEs) in adult malignancies. However, data on the clinical activity of PD-1 inhibition in pediatric patients are lacking. We comprehensively assessed the efficacy and safety of PD-1 inhibitor-based regimens for pediatric malignancies.MethodsWe conducted a real-world, multi-institutional, retrospective analysis of pediatric malignancies treated with PD-1 inhibitor-based regimens. The primary endpoints were objective response rate (ORR) and progression-free survival (PFS). The secondary endpoints included disease control rate (DCR), duration of response (DOR), and AEs. The Kaplan–Meier method was used to calculate PFS and DOR. The National Cancer Institute Common Toxicity Criteria for AEs (version 5.0) were used to grade toxicity.ResultsA total of 93 and 109 patients were evaluated for efficacy and safety, respectively. For all efficacy-evaluable patients, PD-1 inhibitor monotherapy, combined chemotherapy, combined histone deacetylase inhibitor, and combined vascular endothelial growth factor receptor tyrosine kinase inhibitor cohorts, the ORR and DCR were 53.76%/81.72%, 56.67%/83.33%, 54.00%/80.00%, 100.00%/100.00%, and 12.50%/75.00%, respectively; the median PFS and DOR were 17.6/31.2 months, not achieved/not achieved, 14.9/31.2 months, 17.6/14.9 months, and 3.7/1.8 months, respectively; the incidence rate of AEs were 83.49%, 55.26%, 100.00%, 80.00%, and 100.00%, respectively. One patient in the PD-1 inhibitor-combined chemotherapy cohort discontinued treatment due to diabetic ketoacidosis.ConclusionsThis largest retrospective analysis demonstrate that PD-1 inhibitor-based regimens are potentially effective and tolerable in pediatric malignancies. Our findings provide references for future clinical trials and practice of PD-1 inhibitors in pediatric cancer patients.