bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis de los rendimientos de mano de obra en rubros de mampostería en viviendas de dos plantas en la ciudad de Cuenca
Authors: Cruz Espinoza Luis Alberto , Quizhpe Campoverde José David , Mendoza Enríquez Nayra 
Published: February 2023

Introducción. El presente artículo se basa en el análisis de los rendimientos de mano de obra en rubros de mampostería en viviendas de la ciudad de Cuenca, éstos influyen directamente en la productividad y es la parte crucial de la economía de una nación. Los rendimientos utilizados en los presupuestos y programación de obras deben estar fundamentados en múltiples observaciones y análisis estadísticos, en las empresas dedicadas a la construcción muchas de las pérdidas económicas se ven afectadas principalmente por el factor humano y muchas veces no están identificados y cuantificados. Objetivo. Analizar los rendimientos de mano de obra en rubros de mampostería en viviendas de hasta dos plantas en la ciudad de Cuenca, comparando los resultados con la información de la Cámara de la Construcción de Cuenca para generar estrategias de mejora del rendimiento. Metodología. Este estudio se realizó en cuatro etapas: en la primera el levantamiento de información de datos y el cálculo de los rendimientos de mano de obra en rubros de mampostería, en la segunda etapa se realizó la comparación y análisis de datos con la Cámara de la Construcción de Cuenca, en la tercera etapa se realizó una revisión bibliográfica y se definió la estrategia para mejorar los rendimientos de mano de obra en rubros de mampostería, en la cuarta etapa se da recomendaciones de especificaciones técnicas y el correcto proceso constructivo de mampostería. Resultados. A través de la metodología aplicada los resultados resaltan que de los cinco rubros de mampostería en estudio: ladrillo industrial, ladrillo artesanal, ladrillo visto, bloque de pómez y bloque mixto (pómez-hormigón) los rendimientos de mano de obra son inferiores a los de la Cámara de la Construcción de Cuenca, a excepción de ladrillo industrial. Conclusión. Los rendimientos de mano de obra se ven afectados por algunos factores que inciden negativamente en la productividad, pero de los cuales, implementando la estrategia de capacitación a los obreros de la construcción, se espera una mejora significativa.
Pendekatan Whole Language Terhadap Keterampilan Bahasa Indonesia Kelas V SD Ilmu Teknologi Bahasa dan Budaya
Authors: Gunawan Alma Novianti , Latifah Nur , Mawardi Mawardi 
Published: February 2023

Penelitian ini bertujuan mendeskripsikan perencanaan pembelajaran dengan menggunakan pendekatan Whole Language serta mengetahui gambaran tentang pelaksanaan pembelajaran Bahasa Indonesia dengan menggunakan pendekatan Whole Language. Metode penelitian yang dilakukan menggunakan metode Quasi Experiment dengan membandingkan kelas kontrol dan kelas eksperimen. Objek yang diteliti adalah siswa kelas V A sebagai kelas kontrol dan V B sebagai kelas eksperimen, tempat penelitian dilakukan di SD Ilmu Teknologi Bahasa dan Budaya yang bertempat di Pasanggrahan, Kecamatan Solear, Kabupaten Tangerang, Banten. Hasil penelitian ini jika dilihat dari rata-rata kelas, nilai rata-rata siswa pada hasil pretest kelas kontrol sebesar 63,37 dan hasil postest nilai kontrol diperoleh rata-rata sebesar 59,37. Sedangkan nilai rata-rata siswa pretest kelas eksperimen sebesar 57,05, dan rata-rata hasil postest kelas eksperimen sebesar 57,58. Dari hasil uji hipotesis pretest kelas kontrol dan eksperimen menunjukkan taraf signifasi 0.512 > 0,05, dan hasil uji hipotesis postest kelas kontrol dan eksperimen menunjukan taraf signifikansi 0,542 > 0,05. Hal ini menunjukkan H0 diterima dan Ha ditolak, dapat disimpulkan bahwa tidak terdapat pengaruh yang signifikan terhadap perbedaan perlakuan yang diberikan pada kelas kontrol dan eksperimen terhadap keterampilan Bahasa Indonesia.
Harmonizácia daňového práva v Európskej únii
Authors:   Pavol Jozef Šafárik University in Košice, Ristveyová Sandra 
Published: February 2023

Harmonization of EU tax law The article entitled "Harmonization of tax law in the EU" deals with the issue of harmonization of tax liability in the European Union, while the thesis analyzes taxes in the European Union and develops the harmonization of individual taxes. Harmonization is implemented in the area of taxes and indirect taxes. The objectives enshrined in the EU Treaties are achieved through other legislation. In general, the Directive sets out, as a legal act, the objectives to be achieved by the EU Member States. The article contains the most current directives concerning the harmonization of value added taxes. We confirmed the theoretical control and implementation of the EU into the legislation of the Slovak Republic for accidental interventions of the European Union. Analysis of individual deadlines and implementation of confirming work objectives and analysis of harmonization processes in the field of control and determination of taxes, as well as harmonization of processes in the field of tax administration, in EU conditions and their impact on the control of orders in the Slovak Republic. URL: https://vsas.fvs.upjs.sk/
Workflow for computational characterization of PDMS cross-linked systems
Authors: Kampmann Steffen , Croy Alexander , Dianat Arezoo , Cuniberti Gianaurelio 
Published: February 2023

The aim of this work is to demonstrate a computational workflow for the generation of cross-linkable viscoelastic polymers and the determination of elastic and hyperelastic properties by means of all-atoms classical molecular dynamics simulations, using polydimethylsiloxane (PDMS) as an example. To improve the computational efficiency of the workflow, a phenomenological description of the cross-linking process is chosen instead of a quantum mechanical description of the cross-linking mechanism. The structures produced differ in their conversion degree of cross-linking (cdc) of 60, 70, and 80 percent and their quantity ratio between polymer chains and cross-linking units of 2 to 1 and 5 to 1. In order to exclude finite size effects of the molecular systems as much as possible, large systems of about 40,000 atoms are considered. Furthermore, for each possible configuration from the combination of cdc and the ratio of polymer chains to cross-linking units, six structures different from each other are used. Tensile and compression tests are performed to determine mechanical properties. A dependence of stresses in the deformation direction on strain rate is found for strain rates 107, 108, and 109 1/s. As the cdc increases, an increase in the stress values is observed in the tensile tests. To determine the viscoelastic material properties, relaxation tests are performed following the tensile tests. Thereby, the determined relaxed stresses after the tensile test rise with the increase of the cdc. Furthermore, no large stress deviations, .34 MPa maximum, between structures differing by chain to linker ratio are observed with the Ogden model. The computational workflow shows that classical all-atom molecular dynamics simulations can be a suitable method for structure generation and subsequent characterization of elastic and hyperelastic properties of cross-linked polymers.
Oxidative stress induced by berberine-based mitochondria-targeted low temperature photothermal therapy
Authors: Hu Hongzhi , Song Qingcheng , Yang Wenbo , Zeng Qianwen , Liang Zihui , Liu Weijian , Shao Zengwu , Zhang Yiran , Chen Chao , Wang Baichuan 
Published: February 2023

Introduction: Mitochondria-targeted low-temperature photothermal therapy (LPTT) is a promising strategy that could maximize anticancer effects and overcome tumor thermal resistance. However, the successful synthesis of mitochondria-targeted nanodrug delivery system for LPTT still faces diverse challenges, such as laborious preparations processes, low drug-loading, and significant systemic toxicity from the carriers.Methods: In this study, we used the tumor-targeting folic acid (FA) and mitochondria-targeting berberine (BBR) derivatives (BD) co-modified polyethylene glycol (PEG)-decorated graphene oxide (GO) to synthesize a novel mitochondria-targeting nanocomposite (GO-PEG-FA/BD), which can effectively accumulate in mitochondria of the osteosarcoma (OS) cells and achieve enhanced mitochondria-targeted LPTT effects with minimal cell toxicity. The mitochondria-targeted LPTT effects were validated both in vitro and vivo.Results:In vitro experiments, the nanocomposites (GO-PEG-FA/BD) could eliminate membrane potential (ΔΨm), deprive the ATP of cancer cells, and increase the levels of reactive oxygen species (ROS), which ultimately induce oxidative stress damage. Furthermore, in vivo results showed that the enhanced mitochondria-targeted LPTT could exert an excellent anti-cancer effect with minimal toxicity.Discussion: Taken together, this study provides a practicable strategy to develop an ingenious nanoplatform for cancer synergetic therapy via mitochondria-targeted LPTT, which hold enormous potential for future clinical translation.
Body mass index and atrial fibrillation recurrence post ablation: A systematic review and dose-response meta-analysis
Authors: Liu Fuwei , Song Tiangang , Hu Qingwen , Zhu Xin , Zhao Huilei , Tan Ziqi , Yu Peng , Ma Jianyong , Luo Jun , Liu Xiao 
Published: February 2023

ObjectivesThe aim of this study was to evaluate the shape of the dose-response relationship between body mass index (BMI) and atrial fibrillation (AF) recurrence in patients who have undergone radiofrequency ablation.MethodsStudies investigating BMI and AF recurrence in patients with AF after ablation were identified through electronic searches in the PubMed, EMBASE, and Cochrane Library databases. The potential non-linear relationship was fitted using robust error meta-regression. Our study was registered with PROSPERO (CRD42019121373).ResultsTwenty-six cohort studies with 7,878 cases/26,450 individuals were included, and a linear dose-response relationship between BMI and AF recurrence (Pnon–linearity = 0.12) was found. The risk of AF recurrence in patients with a BMI over 28 was significantly increased. Specifically, for each 5 kg/m2 increase in BMI, the risk of AF recurrence increased by 15% (95% CI: 1.08–1.22) with moderate heterogeneity (I2 = 53%). Subgroup analyses showed that the pooled risk ratio was not significantly changed in subgroup analysis adjustment for the following important potential intermediate factors: left atrial diameter and obstructive sleep apnea.ConclusionThis study showed that there is a borderline positive linear association between BMI and AF recurrence post ablation. Overweight and obesity are significantly associated with AF recurrence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42019128770.
Mineral content estimation for salt lakes on the Tibetan plateau based on the genetic algorithm-based feature selection method using Sentinel-2 imagery: A case study of the Bieruoze Co and Guopu Co lakes
Authors: Guo Hengliang , Dai Wenhao , Zhang Rongrong , Zhang Dujuan , Qiao Baojin , Zhang Gubin , Zhao Shan , Shang Jiandong 
Published: February 2023

Salt lakes on the Tibetan Plateau (TP) are rich in lithium (Li), boron (B) and other mineral resources, and accurate assessment of the mineral content and spatial distribution of the brine in those salt lakes is important to guide the development and utilization of their mineral resources. There are few studies estimating the mineral content of salt lakes on the TP due to the lack of in situ investigation data. This study introduced an intelligent prediction model combining a feature selection algorithm with a machine learning algorithm using Sentinel-2 satellite data to estimate the Li, B, and TDS contents of Bieruoze Co and Guopu Co lakes on the TP. First, to enrich the spectral information, four mathematical transformations (reciprocal, logarithmic, reciprocal of logarithm, and first-order derivative) were applied to the original bands. Then, feature selection was performed using the genetic algorithm (GA) to select the optimal input variables for the model. Finally, prediction models were constructed by partial least squares regression (PLSR), multiple linear regression (MLR), and random forest (RF). The results showed that: 1) The spectral mathematical transformation provided rich spectral information for the mineral content estimation. 2) The performance of the estimation model constructed by the feature optimization method using GA was better than that of the estimation model constructed based on all spectral bands. Based on GA for feature optimization, the MAPE of GA-RF for estimating Li, B and TDS contents on the testing set was reduced by 77.52%, 28.54% and 36.79%, respectively. 3) Compared with the GA-MLR and GA-PLSR models, GA-RF estimated Li (R2=0.99, RMSE=1.15 mg L-1, MAPE=3.00%), B (R2=0.97, RMSE=10.65 mg L-1, MAPE=2.73%), and TDS (R2=0.93, RMSE=0.60 g L-1, MAPE=1.82%) all obtained the optimal performance. This study showed that the combination of the GA-based feature selection method and the RF model has excellent performance and applicability for monitoring the content of multiple minerals using Sentinel-2 imagery in salt lakes on the TP.
Teachers’ authentic strategies to support student motivation
Authors: Radil Amanda I. , Goegan Lauren D. , Daniels Lia M. 
Published: February 2023

IntroductionMost theories of motivation have largely developed from the work of scholars rather than the perspectives of teachers. This means that although researchers have many recommendations to guide the way teachers motivate students, there is little understanding of what teachers naturally do to support student motivation. The purpose of this study was to prioritize teachers’ perspectives by asking them, separate from theory, what they do to motivate students.MethodsForty-two practicing teachers completed an open-ended online survey in which they described their personal strategies for motivating students. We used thematic analysis to identify codes and themes from practicing teachers’ responses in a qualitative descriptive design.ResultsWe identified 36 discrete codes that gave rise to nine themes: relevance, interest, relationships, effort, safe environment, goals, student self-regulated learning, delivery, and rewards. Member checks were completed to provide evidence of confidence in the results.DiscussionAll of the strategies that teachers described align with recommendations motivation researchers would make with the exception of rewards, which, from a research perspective, are often discouraged. We discuss the results in light of motivation design principles and their relevance to partnering with teachers as a ubiquitous influence on student motivation.
Remote glucose monitoring is feasible for patients and providers using a commercially available population health platform
Authors: Crossen Stephanie S. , Romero Crystal C. , Lewis Carrie , Glaser Nicole S. 
Published: February 2023

ObjectiveRemote patient monitoring (RPM) holds potential to enable more individualized and effective care for patients with type 1 diabetes (T1D), but requires population analytics to focus limited clinical resources on patients most in need. We explored the feasibility of RPM from patient and provider standpoints using a commercially available data analytic platform (glooko Population Health) among a cohort of youth with T1D.Study designPatients aged 1-20 years with established T1D (≥12 months) and CGM use (≥3 months) were recruited to participate. Participants’ CGM devices were connected to the glooko app and linked to the research team’s glooko account during a one-month baseline period. This was followed by a six-month intervention period during which participants with &gt;15% of glucose values &gt;250 mg/dl or &gt;5% of values &lt;70 mg/dl each month were contacted with personalized diabetes management recommendations. Participants were surveyed about their experiences, and effects on glycemic control were estimated via change in glucose management indicator (GMI) generated from CGM data at baseline and completion. Changes in time spent within various glucose ranges were also evaluated, and all glycemic metrics were compared to a non-randomized control group via difference-in-difference regression, adjusting for baseline characteristics.ResultsRemote data-sharing was successful for 36 of 39 participants (92%). Between 33%-66% of participants merited outreach each month, and clinician outreach required a median of 10 minutes per event. RPM was reported to be helpful by 94% of participants. RPM was associated with a GMI change of -0.25% (P=0.047) for the entire cohort, and stratified analysis revealed greatest treatment effects among participants with baseline GMI of 8.0-9.4% (GMI change of -0.68%, P=0.047; 19.84% reduction in time spent &gt;250 mg/dl, P=0.005).ConclusionsThis study demonstrates the feasibility of RPM for patients with T1D using a commercially available population health platform, and suggests that RPM with clinician-initiated outreach may be particularly beneficial for patients with suboptimal glycemic control at entry. However, larger randomized studies are needed to fully explore the glycemic impact of RPM.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT04696640, identifier NCT04696640.
Analysis of bulk RNA-seq data from sepsis patients reveals sepsis-associated lncRNAs and targeted cell death-related genes contributing to immune microenvironment regulation
Authors: Cheng Yanwei , Xu Lijun , Wang Jiaoyang , Cao Xue , Chen Dong , Zhang Peirong , Yang Lei , Qin Lijie 
Published: February 2023

BackgroundSepsis is a life-threatening organ dysfunction syndrome that leads to the massive death of immune cells. Long non-coding RNAs (lncRNAs) have been reported to exert key regulatory roles in cells. However, it is unclear how lncRNAs regulate the survival of immune cells in the occurrence and development of sepsis.MethodsIn this study, we used blood whole transcriptome sequencing data (RNA-seq) from normal controls (Hlty) and patients with uncomplicated infection (Inf1 P), sepsis (Seps P), and septic shock (Shock P), to investigate the fraction changes of immune cell types, expression pattern of cell death-related genes, as well as differentially expressed lncRNAs. Association network among these factors was constructed to screen out essential immune cell types, lncRNAs and their potential targets. Finally, the expression of lncRNAs and cell death genes in sepsis patients were validated by qRT-PCR.ResultsIn this study, we found fifteen immune cell types showed significant fraction difference between Hlty and three patient groups. The expression pattern of cell death-related genes was also dysregulated in Hlty compared with patient groups. Co-expression network analysis identified a key turquoise module that was associated with the fraction changes of immune cells. We then identified differentially expressed lncRNAs and their potential targets that were tightly associated with the immune cell dysregulation in sepsis. Seven lncRNAs, including LINC00861, LINC01278, RARA-AS1, RP11-156P1.3, RP11-264B17.3, RP11-284N8.3 and XLOC_011309, as well as their co-expressed cell death genes, were finally identified, and we validated two lncRNAs (LINC00861 and LINC01278) and four mRNA targets using qRT-PCR in sepsis samples.ConclusionThe global analysis of cell death-related genes in the occurrence and development of sepsis was carried out for the first time, and its expression regulation mode was displayed. The expression pattern of sepsis-associated lncRNAs were analyzed and identified, and the lncRNAs were significantly related to the change of immune cell proportion. We highlight the important roles of lncRNAs and their potential targets in the regulation of immune cell fraction changes during sepsis progression. The identified lncRNAs and their target genes may become new biomarkers and therapeutic targets of sepsis.
Global trends of Vaccinia oncolytic virus therapy over the past two decades: Bibliometric and visual analysis
Authors: Bo Liu , Tianming Liu , Fengliang Fan , Wenping Liang , Jinzuo Han , Dongbo Xue , Biao Ma , Haijun Sun 
Published: February 2023

BackgroundIn recent years, the vaccinia oncolytic virus has entered the clinical trial stage of examination and shown good progress. It has many advantages, such as good safety, high oncolytic efficiency, and the regulation ability of the tumor microenvironment, and is expected to be successfully used in the clinical treatment of tumors in the future. However, no bibliometric analysis has so far been performed that generalizes horizontally across this field. Therefore, this study aims to assess the research status and trends in this field from a global perspective to help guide future research priorities.MethodsIn this study, the literature related to vaccinia oncolytic virus published in English on Web of Science from 2002 to 2022 was retrieved, and the bibliometric indicators were analyzed using the Histcite. Pro 2.0 tool, while VOSviewer was used to visualize the research trends and hotspots in this field.ResultsIn total, 408 related studies were included. In the past 20 years, the number of related publications in this field has increased year by year, and breakthroughs were made in this field in 2008 and 2013. The research has grown rapidly since 2008, and will likely continue to expand in the years to come. The United States plays a leading role in this area. “MOLECULAR THERAPY-ONCOLYTICS”, “MOLECULAR THERAPY” and “JOURNAL OF TRANSLATIONAL MEDICINE” are core journals that publish high-quality literature on the latest advances in the field. Some authors with numerous high-quality publications include Bell JC and Szalay AA. At present, the research hotspot in this field focus on the clinical application of vaccinia oncolytic virus.ConclusionOverall, the number of vaccinia oncolytic virus-related studies is growing rapidly, in relation to which the United States is the most influential country. The clinical application of vaccinia oncolytic virus will affect the crucial development of future research.