bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geometry‐derived statistical significance: A probabilistic framework for detecting true positive findings in MRI data
Authors: Bansal Ravi , Peterson Bradley S. 
Published: March 2023

AbstractIntroductionThe false discovery rate (FDR) procedure does not incorporate the geometry of the random field and requires high statistical power at each voxel, a requirement not satisfied by the limited number of participants in imaging studies. Topological FDR, threshold free cluster enhancement (TFCE), and probabilistic TFCE improve statistical power by incorporating local geometry. However, topological FDR requires specifying a cluster defining threshold and TFCE requires specifying transformation weights.MethodsGeometry‐derived statistical significance (GDSS) procedure overcomes these limitations by combining voxelwisep‐values for the test statistic with the probabilities computed from the local geometry for the random field, thereby providing substantially greater statistical power than the procedures currently used to control for multiple comparisons. We use synthetic data and real‐world data to compare its performance against the performance of these other, previously developed procedures.ResultsGDSS provided substantially greater statistical power relative to the comparator procedures, which was less variable to the number of participants. GDSS was more conservative than TFCE: that is, it rejected null hypotheses at voxels with much higher effect sizes than TFCE. Our experiments also showed that the Cohen's D effect size decreases as the number of participants increases. Therefore, sample size calculations from small studies may underestimate the participants required in larger studies. Our findings also suggest effect size maps should be presented along withp‐value maps for correct interpretation of findings.ConclusionsGDSS compared with the other procedures provides considerably greater statistical power for detecting true positives while limiting false positives, especially in small sized (<40 participants) imaging cohorts.
Prediction of violence: Part contagious disease, part unpredictable individual: Is a public health assessment approach an additional option and at what cost?
Authors: Hall Ryan C. W. , Iannuzzi Gregory 
Published: March 2023

AbstractOn a population level, violence shares many similarities with communicable disease states and other public health issues. Therefore, there has been a push to apply public health interventions to the problem of societal violence and for some to even identify violence as the product of a disease state (e.g., changed brain). This conceptualization could lead to the development of new risk violence assessment tools and approaches predicated more on the public health model rather than existing instruments that have often been based on inpatient mental health populations or incarcerated populations. In this article, we will discuss aspects of legal obligation for risk violence “prediction/stratification”, the application of the public health communicable disease model to violence, as well as identify why it may not always translate to the individual with whom a clinician or forensic mental health evaluator interacts.
Role of YES1 signaling in tumor therapy resistance
Authors: Zhou Hai , Sun Dantong , Tao Junyan , Xu Mingjin , Zhang Xiaochun , Hou Helei 
Published: March 2023

AbstractYES proto‐oncogene 1 (YES1) is an SRC family kinase (SFK) that plays a key role in cancer cell proliferation, adhesion, invasion, survival, and angiogenesis during tumorigenesis and tumor development. Reports suggest that YES1 amplification is associated with resistance to chemotherapeutic drugs and tyrosine kinase inhibitors (TKIs) in human malignancies. However, the mechanisms of drug resistance have not been fully elucidated. In this article, we review the literature on YES1 and discuss the implications of YES1 signaling for targeted therapy and chemotherapy resistance in malignancies. Moreover, recent advances in targeted therapy for YES1‐amplified malignancies are summarized. Finally, we conclude that targeting YES1 may reverse drug resistance and serve as a valuable tumor treatment strategy.
Butanol Extract of Acanthopanax senticosus (Rupr. et Maxim.) Harms Alleviates Atherosclerosis in Apolipoprotein E‐Deficient Mice Fed a High‐Fat Diet
Authors: Jia Ailing , Shi Yuwen , Zhang Yuhang , Diao Yuanyuan , Chang Baijin , Jiang Mengcheng , Liu Weipeng , Qiu Zhidong , Fu Chaomei , Qiu Ye 
Published: March 2023

AbstractThis study investigated the effect of butanol extract of AS (ASBUE) on atherosclerosis in apolipoprotein E‐deficient (ApoE−/−) mice. The mice were administered ASBUE (390 or 130 mg/kg/day) or rosuvastatin (RSV) via oral gavage for eight weeks. In ApoE−/− mice, ASBUE suppressed the abnormal body weight gain and improved serum and liver biochemical indicators. ASBUE remarkably reduced the aortic plaque area, improved liver pathological conditions, and lipid metabolism abnormalities, and altered the intestinal microbiota structure in ApoE−/− mice. In the vascular tissue of ASBUE‐treated mice, P‐IKKβ, P‐NFκB, and P‐IκBα levels tended to decrease, while IκB‐α increased in high fat‐diet‐fed atherosclerotic mice. These findings demonstrated the anti‐atherosclerotic potential of ASBUE, which is mediated by the interaction between the gut microbiota and lipid metabolism and regulated via the Nuclear Factor‐kappa B (NF‐κB) pathway. This work paves the groundwork for subsequent studies to develop innovative drugs to treat atherosclerosis.
Five New Oleanane Triterpene Saponins from Camellia petelotii and Their Alpha‐glucosidase Inhibitory Activity
Authors: Thi Cuc Nguyen , Anh Bang Ngo , Huu Tai Bui , Xuan Nhiem Nguyen , Hai Yen Pham , Thi Hai Yen Duong , Thi Thu Hien Truong , Thi Huyen Le , Van Kiem Phan 
Published: March 2023

AbstractFive new triterpenoid glycosides, named campetelosides A–E (1–5), together with three known compounds, chikusetsusaponin IVa (6), umbellatoside B (7), and silvioside E (8) were isolated from the leaves of Camellia petelotii (Merr.) Sealy. Their chemical structures were determined by interpretations of HR‐ESI‐MS and NMR spectra. In addition, compounds 1–8 were evaluated for their α‐glucosidase inhibitory effects. Compounds 1–3 significantly showed α‐glucosidase inhibitory activity with IC50 values of 166.7±6.0, 45.9±2.6, and 395.3±10.5 μM, respectively, compared to that of the positive control, acarbose, with an IC50 value of 200.4±10.5 μM.
Successful treatment with ivabradine in a β‐blocker‐refractory patient with acute decompensated heart failure with reduced ejection fraction
Authors: Inoue Tomoko , Matsunaga Keiji , Kobayashi Waki , Minamino Tetsuo 
Published: March 2023

AbstractIvabradine is an established treatment for chronic heart failure with reduced ejection fraction (HFrEF); however, it is not used for acute heart failure treatment. Negative inotropic effects (NIE) often limit the up‐titration of β‐blockers. Contrarily, ivabradine has no NIE, and enables β‐blockers usage for treating patients with acute decompensated HFrEF.
Atypical truncal necrobiosis lipoidica: The role of dermoscopy
Authors: Thabouti Marwa , Ghariani Fetoui Nadia , Mani Oumaima , BelKahla Marwouene , Mokni Sana , Sriha Badreddine , Ghariani Najet , Denguezli Mohamed 
Published: March 2023

AbstractNecrobiosis Lipoidica (NL) is a rare granulomatous skin condition typically occurring in lower extremities. We report an atypical case of NL, and we highlight the role of dermoscopy in the diagnostic approach.
Co‐infection of coronavirus disease 19 and cytomegalovirus in a kidney transplant recipient
Authors: Farrokhnia Mehrdad , Baniasad Amir , Mehdiabadi Fatemeh Mousavi 
Published: March 2023

AbstractIt has been suggested that severe SARS‐CoV‐2 infection could be a risk factor for Herpesviridae reactivation due to the state of sepsis‐associated immunosuppression. We presented the case of co‐infection of CMV and COVID‐19 infection in a 43‐year‐old woman with end‐stage renal disease.
Non‐contiguous multilevel spinal tuberculosis: A case report of unusual spinal tuberculosis resembling spinal metastasis
Authors: Fard Salman Abbasi , Pourzand Pouria , Tabasi Farhad , Mohammadi Mohsen , Nafeli Mohammad , Jourahmad Zahra 
Published: March 2023

AbstractSpinal tuberculosis (TB) is diagnostically challenging, particularly in atypical forms. Non‐contiguous multilevel spinal TB (NMLST) is a rare presentation of spinal TB, mimicking spinal malignancies. We reported an unusual NMLST case with a paraspinal and epidural abscess in a young patient with misleading clinical and imaging presentations.
Numerical simulation and experimental validation of thrombolytic therapy for patients with venous isomer and normal venous valves
Authors: Lin Boyuan , Zhang Xianglei , Xu Jiangping , Ni Haoqi , Lv Xinhuang 
Published: March 2023

AbstractThrombus is an extremely dangerous factor in the human body that can block the blood vessel. Once thrombosis happens in venous of lower limbs, local blood flow is impeded. This leads to venous thromboembolism (VTE) and even pulmonary embolism. In recent years, venous thromboembolism has frequently occurred in a variety of people, and there is no effective treatment for patients with different venous structures. For the patients with venous isomer with single valve structure, we establish a coupled computational model to simulate the process of thrombolysis with multi‐dose treatment schemes by considering the blood as non‐Newtonian fluid. Then, the corresponding in vitro experimental platform is built to verify the performance of the developed mathematical model. At last, the effects of different fluid models, valve structures and drug doses on thrombolysis are comprehensively studied through numerical and experimental observations. Comparing with the experimental results, the relative error of blood boosting index (BBI) obtained from non‐Newtonian fluid model is 11% smaller than Newtonian fluid. In addition, the BBI from venous isomer is 1300% times stronger than patient with normal venous valve while the valve displacement is 500% times smaller. As consequence, low eddy current and strong molecular diffusion near the thrombus in case of isomer promote thrombolysis rate up to 18%. Furthermore, the 80 μM dosage of thrombolytic drugs gets the maximum thrombus dissolution rate 18% while the scheme of 50 μM doses obtains a thrombolysis rate of 14% in case of venous isomer. Under the two administration schemes for isomer patients, the rates from experiments are around 19.1% and 14.9%, respectively. It suggests that the proposed computational model and the designed experiment platform can potentially help different patients with venous thromboembolism to carry out clinical medication prediction.
Symptom severity in daily life, early response and posttreatment changes in anxiety and depressive symptoms in generalized anxiety disorder
Authors: Vîslă Andreea , Probst Greta Helene , Flückiger Christoph 
Published: March 2023

AbstractBackgroundMeta‐analytic research shows early response to psychotherapy to predict depression and anxiety outcomes posttreatment. However, little is known about which variables explain differences in early response. Moreover, for patients with generalized anxiety disorder (GAD), there is limited research on whether early response predicts longer‐term changes in symptoms. In this study, we used anxiety and controllability beliefs assessed in daily life at intake to predict early response to treatment (until session 5), and we further examined if early response predicts longer‐term changes in symptoms (until posttreatment, when adjusting for intake symptom severity) in patients with GAD.MethodsForty‐nine individuals with GAD reported their anxiety and controllability beliefs using event‐based (participant‐initiated) ecological momentary assessment (EMA) for 7 days at intake. Symptoms were measured at pretreatment, session 5, session 10, and posttreatment.ResultsResults show anxiety levels reported during EMA to be associated with a higher reduction in both anxiety and depressive symptoms early in treatment. Moreover, higher controllability beliefs during EMA were associated with less early response. When predicting change in symptoms until posttreatment, results showed an early change to significantly predict change in symptoms until posttreatment.ConclusionsGiven that we found early response to psychotherapy in patients with GAD to be a prognostic factor for long‐term response, it is recommended to monitor response early in treatment and pay special attention to those patients showing less early response.
Mentalizing ability, mentalizing impairments, and anorexia nervosa: Validation of the Hebrew version of the Movie for the Assessment of Social Cognition (MASC)
Authors: Sarig‐Shmueli Yaara , Kurman Jenny , Talmon Shira , Yoeli Neta , Gur Eitan , Stein Daniel , Rothschild‐Yakar Lily 
Published: March 2023

AbstractThe goal of this study was to validate the Hebrew version of the Movie for the Assessment of Social Cognition (MASC)—an ecological measure for assessing mentalizing ability—among patients with anorexia nervosa (AN) and healthy individuals. We examined the validity of the MASC's general mentalizing ability scale and of its mentalizing impairments subscales using validated measures of mentalizing ability (Reading the Mind in the Eyes test, Cambridge Mindreading Face‐Voice Battery, and Reflective Function questionnaire) among female patients with AN (N = 35) and control participants (N = 42). ED symptoms were assessed via self‐report questionnaires. The MASCHeb correlated with measures of mentalizing ability and was found to significantly differentiate patients with AN from controls. In addition to differing on general mental ability, the groups differed on hypomentalizing (but not hypermentalizing). Based on our findings, the MASCHeb proved to be an ecologically valid tool for assessing mentalizing ability and impairments among patients with AN. Moreover, our findings demonstrated the role played by general mentalizing ability in EDs and specifically pointed to the importance of hypomentalization in EDs. These findings have therapeutic implications, as outlined in the Discussion section.
A Review on Lead‐Free Perovskites for X‐Ray Detection and Imaging
Authors: Zhang Xin , Yu Shouwu , Meng Xianguang , Xiao Shujuan 
Published: March 2023

AbstractRecently, perovskites have shown great promise as a semiconductor material with the advantages of low‐temperature fabrication, controllable band gap, and high carrier lifetime. In the field of X‐ray detection, a number of workers have developed green and stable and efficient lead‐free halide chalcogenides in pursuit of stable performance and biological safety. This article has done the following three works: It introduces the basic principles of X‐ray detection briefly. The outstanding works that have been done are summarized in terms of sensitivity, signal‐to‐noise ratio, and detection limit, and their laws are summarized. The optoelectronic properties of lead‐free halide perovskites are summarized, the prospects of lead‐free perovskites in the field of X‐ray detection are foreseen.
Development of Large‐Diameter and Very High Purity Ge Crystal Growth Technology for Devices
Authors: Sumathi Rajappan Radhakrishnan , Gybin Alexander , Gradwohl Kevin‐P. , Palleti Pradeep Chandra , Pietsch Mike , Irmscher Klaus , Dropka Natasha , Juda Uta 
Published: March 2023

AbstractHigh‐purity germanium (HPGe) single crystals find their applications as radiation detectors especially for spectroscopy of high‐energy photons and particles in nuclear physics. Growing “detector‐grade” HPGe single crystals, with tailored structural defects and controlled impurity content, uniform throughout the crystal is a challenging task in this type of crystalline semiconductor material. All different process steps for HPGe, namely, i) reducing germanium dioxide powder into Ge metal; ii) zone refining of intrinsic source material (6 N) up to an ultrahigh purity (13 N); iii) Czochralski growth of high‐purity single crystals, are developed in house. A specific preparatory coating process for zone refining is entrenched as part of this work. Gallium, a dominant impurity usually found in HPGe, can be avoided. Using these advanced process know‐hows, a technology to grow volume Ge single crystals of large diameter (3 in.) with very high purity (net carrier concentration ≈ 5 × 1010 cm−3 or equivalent to 1 part per trillion level) is successfully developed. The zone‐refined Ge bars and the crystals show p‐type conductivity. Some crystals exhibit n‐type conductivity, and n–p or p–n transition is encountered in a single growth experiment. Besides the first results of encompassing very high‐purity crystals with uniform diameter, a controlled dislocation density (≈104 cm−2) can be realized.
Complementary Operando Electrochemical Quartz Crystal Microbalance and UV/Vis Spectroscopic Studies: Acetate Effects on Zinc‐Manganese Batteries
Authors: He Zi‐Fan , Lu Yi‐Ting , Wei Tzu‐Chien , Hu Chi‐Chang 
Published: March 2023

AbstractZinc‐ion batteries, in which zinc ions and protons do intercalation and de‐intercalation during battery cycling with various proposed mechanisms under debate, have been studied. Recently, electrolytic zinc‐manganese batteries, exhibiting the pure dissolution‐deposition behavior with a large charge capacity, have been accomplished through using electrolytes with Lewis acid. However, the complicated chemical environment and mixed products hinder the investigation though it is crucial to understand the detailed mechanism. Here, cyclic voltammetry coupled electrochemical quartz crystal microbalance (EQCM) and ultraviolet‐visible spectrophotometry (UV–Vis) are respectively, for the very first time, used to study the transition from zinc‐ion batteries to zinc electrolytic batteries by the continuous addition of acetate ions. These complementary techniques operando trace the mass and the composition evolution. The observed formation and dissolution of zinc hydroxide sulfate (ZHS) and manganese oxides evince the effect of acetate ions on zinc‐manganese batteries from an alternative perspective. Both the amount of acetate and the pH value have large impacts on the capacity and Coulombic efficiency of the MnO2 electrode, and thus they should be optimized when constructing a full zinc‐manganese battery with high rate capability and reversibility.
Digital droplet PCRTERT promoter mutational screening in fine needle aspiration cytology of thyroid lesions: A highly specific technique for pre‐operative identification of high‐risk cases
Authors: Hysek Martin , Hellgren L. Samuel , Stenman Adam , Darai‐Ramqvist Eva , Ljung Elin , Schliemann Igor , Condello Vincenzo , Larsson Catharina , Zedenius Jan , Jatta Kenbugul , Juhlin C. Christofer 
Published: March 2023

AbstractBackgroundDespite the advent of comprehensive molecular testing in surgical pathology, most centers still rely on the morphological assessment of fine‐needle aspiration cytology (FNAC) to triage patients with thyroid nodules for surgery. Subsets of patients could benefit from the inclusion of molecular testing to increase the diagnostic and/or prognostic properties of the cytology analysis, including the assessment of TERT promoter mutations, an event coupled with thyroid malignancy, and poor prognosis.MethodsIn this prospective study, preoperative FNAC material from 65 cases was assessed for TERT promoter hotspot mutations C228T and C250T using the digital droplet PCR (ddPCR) technique on frozen pellets and re‐evaluated postoperatively.ResultsOur cohort consisted of 15 B‐III (23%), 26 B‐IV (40%), 1 B‐V (2%), and 23 (35%) B‐VI lesions according to the Bethesda System for Reporting Thyroid Cytopathology. TERT promoter mutations were detected in 7 cases; 4 papillary thyroid carcinomas (all with preoperative B‐VI status), two follicular thyroid carcinomas (one B‐IV and one B‐V status), and one poorly differentiated thyroid carcinoma (with B‐VI status). All mutated cases were verified by mutational analysis of tumor tissue derived from postoperative formalin‐fixed paraffin‐embedded tissue, while all cases identified as wild‐type on FNAC remained wild‐type postoperatively. Moreover, the occurrence of a TERT promoter mutation was significantly associated with malignant disease and higher Ki‐67 proliferation indices.ConclusionIn the present cohort, we found that ddPCR is a highly specific method for detecting high‐risk TERT promoter mutations on thyroid FNAC material that could guide different surgical approaches in subsets of indeterminate lesions if reproduced in larger materials.
The sedimentological expression of transgression–regression cycles upon aeolian–marine margins
Authors: Cross S. , Pettigrew R. P. , Priddy C. L. , Zuchuat V. , Dodd T. J. H. , Mitten A. J. , Clarke S. M. 
Published: March 2023

AbstractWhen compared to their temperate coastal counterparts, sediments deposited and preserved along arid aeolian to shallow‐marine margins remain relatively poorly understood, particularly at the scale of lithofacies units and architectural elements. These systems often record evidence for relative sea‐level change within sedimentary basins. This work focusses on the Entrada–Curtis–Summerville formations that crop out in central eastern Utah, USA, and provides a detailed analysis of the aeolian Moab Member of the Curtis Formation (informally known as the Moab Tongue) that was impacted by cycles of marine transgressions and regression in the late Jurassic. This study utilises photogrammetry, sedimentary logging and sequence‐stratigraphical analysis techniques. Results indicate that four short‐lived transgressive‐regressive cycles are preserved within the Moab Member, followed by a broad regressive event recorded at the transition between the Curtis and Summerville formations. These cycles relate to changes in the relative sea level of the Sundance Sea and the deflation and expansion of the neighbouring aeolian dune field. During periods of normal regression, marine sediments displayed evidence of tidal and wave action, whereas the continental domain was characterised by growth of the aeolian system. However, when regression occurred within optimal physiographic conditions such as a restricted, semi‐enclosed basin, and at sufficient magnitude to outpace erg expansion, this acted to shut‐down bedform development and preservation. A rapid restriction of aeolian sediment availability and the inability of the dune field to recover resulted in the formation of deflationary sandsheets, arid coastal plain strata and contemporaneous shallow‐marine deposits that are starved of wind‐sourced sediments. This study highlights how a rapidly developing high‐magnitude regression can lead to the overall retraction of the erg. Deciphering the evolution and sequence stratigraphical relationships of arid aeolian to shallow marine margins is important in both understanding environmental interactions and improving the characterisation of reservoir rocks deposited in these settings.