bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benzene Sulfonyl Linked Tetrasubstituted Thiacalix[4]arene for Selective and Sensitive Fluorometric Sensing of Sulfosulfuron Along with Theoretical Studies
Authors: Kashyap Priyanka , Rajpurohit Dushyantsingh , Modi Krunal , Bhasin Hinaly , Fernandes Patrick , Mishra Divya 
Published: January 2023

Abstract
Herein, we designed two fluorescent Tetrasubstituted Benzene sulfonyl appended Thiacalix[4]arene receptors named PK1–2 which sensitively and selectively detect Sulfosulfuron among other herbicides and pesticides. The detection limit (LOD) was found to be 0.21 ppm and 0.35 ppm, and the Enhancement constant (Ks) was determined 7.07 X 104 M− 1 and 5.55 X 104 M− 1 for PK1 and PK2 respectively. Using the Non-linear regression method, the Association constant was obtained as 2.1 X 104 M− 1 and 2.23 X 104 M− 1 whereas the binding ratio was found to be 1:1 for both PK1–2 respectively. Additionally, the interference studies show the selective nature of receptors for Sulfosulfuron among its sulfonylurea family. To further confirm the binding mechanism computational investigation was carried out, which validates the 1:1 binding ratio. The receptors were found to be recyclable in nature with simple Acid-Base treatment. This new approach of using Supramolecules as fluorescent probes for sensitive and selective detection of herbicides are rare in the literature.
Increased level of PD1 and glycolysis in CD4 + T cell promote lymph node metastasis in OSCC patient
Authors: Wu Kun , Han Nannan , Mao Yuanyuan , Li Yan 
Published: January 2023

Abstract
Background
Cervical lymph node metastasis is one of the poorest prognostic factors in oral squamous cell carcinoma (OSCC). Activated immune cells generally have metabolic abnormality in tumor microenvironment. However, it is unknown whether abnormal glycolysis in T cells could facilitate metastatic lymph nodes in OSCC patients.
Methods
Flow cytometry and immunofluorescence staining were used to analyze the differences in CD4 + PD1 + T cells between metastatic (LN+) and negative (LN-) lymph nodes. RT-PCR was performed to detail the expression of immune checkpoints and glycolysis-related enzymes in LN + and LN-.
Results
The frequency of CD4+ T cells decreased in LN+ (p = 0.0019). The PD1 expression of LN + increased markedly compared to that of LN- (p = 0.0205). Similarly, the PD1 of CD4+ T cells in LN + increased significantly compared to that of LN-. Moreover, glycolysis-related enzyme levels in CD4 + T cells from LN + were dramatically higher than those in LN-. Moreover, PD1 and Hk2 expressions in CD4 + T cells increased in LN + of OSCC patients with prior surgical treatment compared to those without.
Conclusions
These findings suggest that increased PD1 and glycolysis in CD4+ T cells may serve as pivotal regulators of OSCC metastatic lymph nodes, which are closely associated with elevated glycolysis.
Storm surge and tsunami deposits along the Moroccan coasts: state of the art and future perspectives
Authors: KHALFAOUI Otmane , Dezileau Laurent , Mhammdi Nadia , Medina Fida , Mojtahid Meryem , Raji Otmane , Talibi Hajar El , Mellas Samira , Degeai Jean-Philipe , Khalidi Khaldi El , Snoussi Maria , Bendahhou Zourarah , Aboumaria Khadija 
Published: January 2023

Abstract
The Moroccan coast is occasionally confronted with marine submersion events caused by storm surges and tsunamis. The Moroccan historical archives recorded some of these events, such as the storm surge of 2014 CE and the tsunami of 1755 CE. The latter remains the most destructive event the country has ever faced, with major human and economic losses recorded mainly between the two cities of Tangier and Safi. The privileged way to prevent any hazard related to these events is to study their past occurrences and consequences. However, historical records are often very scarce to determine their return periods and evaluate their intensities. Accordingly, the scientific community increasingly uses sedimentary archives from coastal environments, since they offer a viable alternative to historical archives. Several studies using this approach have been conducted on the Moroccan coast in recent years; however, until now, there has been no review dealing with these studies, which is the main objective of this paper. The present review shows that most of the Moroccan sites containing marine submersion deposits are located along the Atlantic coast. The Mediterranean coast remain poorly studied despite the presence of tsunami and storm surge risks. The review draws attention also to the absence of chronological data for most of the marine submersion deposits recognized up to now along the Moroccan coasts, which is a major issue that prevents the determination of the return period of these events.
Nutrient and crop establishment methods determine carbon efficiency and crop-water productivity in intensive rice-based cropping system in Eastern India
Authors: Behera Stuti D , Garnayak Lalita Mohan , Behera Basudev , Sarangi Sukanta Kumar , Jena Jagadish , Behera Swosti D , Dwibedi Sanat Kumar 
Published: January 2023

Abstract

Achieving sustainable crop-water productivity and carbon efficiency of intensive cropping systems such as rice (Oryza sativa)-toria(Brassica campestrisL. var. toria)-sweet corn (Zea mays con var. saccharata var. rugosa) system in Eastern India, need synergies of nutrient management, rice variety and crop establishment methods. Efficient nutrient management in rice, tillage and establishment oftoriaand sweet corn, were identified in two years (2018-19 and 2019-20) replicated field experiment conducted at Bhubaneswar, Odisha, India. The treatments comprising of three nutrient management [N1: 100% Soil Test Based Nitrogen Recommendation (STBNR), N2: 75% STBNR +in situgreen manuring ofDhaincha(GM) and N3: 50% STBNR + GM in rice, two rice varieties (V1: ‘Manaswini’ of 130 d duration and V2: ‘Hasanta’ of 145 d duration) and three crop establishment methods intoria viz., E1: Zero Till-Flat Bed (ZT-FB), E2: Conventional Till-Flat Bed (CT-FB) and E3: Conventional Till-Furrow Irrigated Raised Bed (CT-FIRB) were tried in split plot design with four replications. Sweet corn was grown aftertoriafollowing the same lay out. Application of 75% STBNR+GM proved to be the best with the maximum system rice equivalent yield (REY) of 21.10 t ha-1, input water productivity (IWP) of 0.44 kg REY ha-mm-1, C output of 14,484 kg ha-1, carbon efficiency (CE) of 8.58 and carbon sustainability index (CSI) of 7.58. ‘Manaswini’ rice-based system registered 4% higher REY as compared to ‘Hasanta’ rice-based system, but both systems were at par for IWP, carbon output, CE and CSI. System involving CT-FIRB recorded the maximum REY, IWP and carbon output, registering marginally higher values than ZT-FB and significantly higher value than CT-FB. Both CT-FIRB and ZT-FB were at par for CE and CSI.
Quest Markup for Developing FAIR Questionnaire Modules for Epidemiologic Studies
Authors: Russ Daniel E. , Gerlanc Nicole M. , Shen Brian , Patel Bhaumik , González Amy Berrington , Freedman Neal D. , Cusack Julie M. , Gaudet Mia M. , García-Closas Montserrat , Almeida Jonas S. 
Published: January 2023

Abstract
Background
Online questionnaires are commonly used to collect information from participants in epidemiological studies. This requires building questionnaires using machine-readable formats that can be delivered to study participants using web-based technologies such as progressive web applications. However, the paucity of open-source markup standards with support for complex logic make collaborative development of web-based questionnaire modules difficult. This often prevents interoperability and reusability of questionnaire modules across epidemiological studies.
Results
We developed an open-source markup language for presentation of questionnaire content and logic, Quest, within a real-time renderer that enables the user to test logic (e.g., skip patterns) and view the structure of data collection. We provide the Quest markup language, an in-browser markup rendering tool, questionnaire development tool and an example web application that embeds the renderer, developed for The Connect for Cancer Prevention Study.
Conclusion
A markup language can specify both the content and logic of a questionnaire as plain text. Questionnaire markup, such as Quest, can become a standard format for storing questionnaires or sharing questionnaires across the web. Quest is a step towards generation of FAIR data in epidemiological studies by facilitating reusability of questionnaires and data interoperability using open-source tools.
Persistently high platelet factor 4 levels in an adolescent with recurrent late thrombotic complications after SARS-CoV-2 mRNA vaccination: A case report
Authors: Haga Yoichi , Ohara Akira , Yakuwa Tsuneyoshi , Yamashita Akari , Udo Midori , Matsuoka Masaki , Yasumoto Atsushi , Takahashi Hiroyuki 
Published: January 2023

Abstract
Background
Thrombosis after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is a serious complication for patients with a thrombophilic predisposition. Factors that predict the risk of post-vaccination thrombosis should be explored. We report a case in which a patient with pediatric antiphospholipid syndrome (APS) developed deep vein thrombosis (DVT) six months after receiving a second dose of the BNT162b2 vaccine.
Case presentation:
A 17-year-old girl with no family history of thrombophilia developed DVT at six years of age. The thrombus was found in the right common iliac vein and the inferior vena cava, with concomitant left pulmonary infarction. After treatment with warfarin, the pulmonary infarction was resolved, but the thrombus became organized and persisted for the next 11 years. The patient was treated with anticoagulants for six years after DVT onset, with subsequent cessation of treatment for five years without thrombosis recurrence. She received the BNT162b2 vaccine at 17 years of age, one week before a routine outpatient visit. Elevation of platelet factor 4 level was detected 14 days after the first vaccination and remained for five months after that, but without thrombotic symptoms. A second dose of the BNT162b2 vaccine was administered; six months later, the DVT in the right common iliac vein recurred and was treated with a direct oral anticoagulant.
Conclusions
The BNT162b2 vaccine exacerbated her antiphospholipid antibody syndrome by activating the coagulation system, thereby exacerbating her thrombosis. Platelet factor 4 may be a useful indicator of the coagulation system. The persistence of high platelet factor 4 levels after vaccination suggests that the vaccine caused DVT by exacerbating the patient’s APS. After vaccination of patients with a predisposition to thrombosis, coagulation status and platelet activation markers should be monitored to prevent the development of DVT.
Towards a Better Understanding of the Characteristics of Fractal Networks
Authors: Zakar-Polyák Enikő , Nagy Marcell , Molontay Roland 
Published: January 2023

Abstract
The fractal nature of complex networks has received a great deal of research interest in the last two decades. Similarly to geometric fractals, the fractality of networks can also be defined with the so-called box-covering method. A network is called fractal if the minimum number of boxes needed to cover the entire network follows a power-law relation with the size of the boxes. The fractality of networks has been associated with various network properties throughout the years, for example, disassortativity, repulsion between hubs, long-range-repulsive correlation, and small edge betweenness centralities. However, these assertions are usually based on tailor-made network models and on a small number of real networks, hence their ubiquity is often disputed.
Since fractal networks have been shown to have important properties, such as robustness against intentional attacks, it is in dire need to uncover the underlying mechanisms causing fractality. Hence, the main goal of this work is to get a better understanding of the origins of fractality in complex networks. To this end, we systematically review the previous results on the relationship between various network characteristics and fractality. Moreover, we perform a comprehensive analysis of these relations on five network models and a large number of real-world networks originating from six domains. We clarify which characteristics are universally present in fractal networks and which features are just artifacts or coincidences.
Autoencoder-enabled Model Portability for Reducing Hyperparameter Tuning Efforts in Side-channel Analysis
Authors: Krček Marina , Perin Guilherme 
Published: January 2023

Abstract
Hyperparameter tuning represents one of the main challenges in deep learning-based profiling side-channel analysis. For each different side-channel dataset, the typical procedure to find a profiling model is applying hyperparameter tuning from scratch. The main reason is that side-channel measurements from various targets contain different underlying leakage distributions. Consequently, the same profiling model hyperparameters are usually not equally efficient for other targets. This paper considers autoencoders for dimensionality reduction to verify if encoded datasets from different targets enable the portability of profiling models and architectures. Successful portability reduces the hyperparameter tuning efforts as profiling model tuning is eliminated for the new dataset, and tuning autoencoders is simpler. We first search for the best autoencoder for each dataset and the best profiling model when the encoded dataset becomes the training set. Our results show no significant difference in tuning efforts using original and encoded traces, meaning that encoded data reliably represents the original data. Next, we verify how portable is the best profiling model among different datasets. Our results show that tuning autoencoders enables and improves portability while reducing the effort in hyperparameter search for profiling models. Lastly, we present a transfer learning case where dimensionality reduction might be necessary if the model is tuned for a dataset with fewer features than the new dataset. In this case, tuning of the profiling model is eliminated and training time reduced.
Enhanced Electrochemical and Corrosion Behavior of Amorphous 316-type Stainless Steel Microfibers in Saline Environment
Authors: Sarac Baran , Sharifikolouei Elham , Zheng Yonghui , Yüce Eray , Asci Atacan , Keckes Jozef , Sarac A. Sezai , Eckert Jürgen 
Published: January 2023

Abstract
The resistance of commercial stainless steel (SS) types in harsh environments is problematic because of the breakdown of the passive chromium oxide layer. This study reports fully amorphized 316 SS microfibers using a customized multi-nozzled melt-spinning technique. Electrochemical tests in 3.5 wt.% NaCl shows a high corrosion resistance with an annual corrosion rate of less than 60 µm year–1 under ambient conditions, which increases slightly as the temperature rises to 50°C. The room temperature sample also shows a low passivation current at the level of 10–4 A cm–2 with long-term stability, and no pitting is observed for all the samples until 1.5 V. The sample polarized at 37°C shows the smallest bulk resistance (~ 1400 Ω cm2) and the largest double-layer capacitance (28.6 µF cm–2), where large amounts of salt accumulation on the surface creating a passive layer on the microfibers were detected by energy dispersive X-ray (EDX)–scanning electron microscopy. Cross-sectional investigation by EDX-scanning transmission electron microscopy corroborates the homogenous bulk composition and Fe-rich, Ni and Cr-containing amorphous oxides, both of which contribute to the enhanced corrosion and passivation properties compared to commercial SS counterparts in the literature.
Increasing influenza vaccination coverage in healthcare workers: Analysis of an intensified on-site vaccination campaign during the COVID-19 pandemic
Authors: Schumacher Sofie , Salmanton-García Jon , Liekweg Andrea , Rolfes Muriel , Seidel Danila , Mellinghoff Sibylle C. , Cornely Oliver A. 
Published: January 2023

Abstract
Purpose: Influenza infections have a substantial impact on health care institutions. While vaccination is the most effective preventive measure against influenza infections, overall vaccination coverage in healthcare workers is low. The study was conducted to investigate the impact of an intensified influenza vaccination campaign in a maximum-care hospital on influenza vaccination coverage in healthcare workers during the COVID-19 pandemic in 2020/21.
Methods: Vaccination coverage following an intensified influenza vaccination campaign comprising a mobile vaccination team providing on-site vaccination and vaccination at a recurring central vaccination site in addition to promotional measures was analysed. A survey querying vaccination motivation was performed. Additionally, campaign strategies and respective vaccination coverage of influenza seasons between 2017/18 and 2019/20 were analysed.
Results: The intensified influenza vaccination campaign 2020/21 led to a significant 2.4-fold increase yielding an overall vaccination coverage of 40% among healthcare workers. A significant increase in vaccination coverage was observed across all professional fields, especially among nurses, a 2.7-fold increase, reaching a vaccination coverage of 48% was observed. The COVID-19 pandemic positively influenced vaccination decision in 72% of first-time ever or first-time in over ten years influenza vaccinees. Vaccination coverage during prior vaccination campaigns focusing on educational measures did not exceed 17%.
Conclusion: A mobile vaccination team providing on-site vaccination and vaccinations at a central vaccination site in addition to intensified promotional measures can be implemented to increase influenza vaccination coverage in healthcare workers. Our concept can inform future influenza and other vaccination campaigns for healthcare workers.
Isosorbide DiNitrate Effect on Hemodynamic Profile, Liver Stiffness, and Exercise Tolerance in Fontan Circulation (The NEET Clinical Trial)
Authors: Bigelow Amee M. , Riggs Kyle W. , Morales David L. S. , Lubert Adam M. , Opotowsky Alexander R. , Dillman Jonathan R. , Veldtman Gruschen R. , Heydarian Haleh C. , Trout Andrew T. , Cooper David S. , Goldstein Stuart L. , Chin Clifford , Palermo Joseph J. , Ollberding Nicholas J. , Mays Wayne A. , Alsaied Tarek 
Published: January 2023

Abstract
Introduction: After Fontan operation, decreased venous capacitance and venoconstriction are adaptive mechanisms to maintain venous return and cardiac output. The consequent higher venous pressure may adversely impact end-organ function, exercise capacity and result in worse clinical outcomes. This pilot study evaluated the safety and effect of isosorbide dinitrate (ISDN), a venodilator, on exercise capacity, peripheral venous pressure (PVP), and liver stiffness in patients with Fontan circulation.
Methods: In this prospective single-arm trial, 15 individuals with Fontan circulation were evaluated at baseline and after four weeks of therapeutic treatment with ISDN. Primary aims were to assess the safety of ISDN and the effect on maximal exercise (peak oxygen consumption, peak VO2). We also aimed to assess the effect of ISDN on ultrasound-assessed liver stiffness, markers of submaximal exercise, and PVP at rest and peak exercise. Repeated measures t-tests were used to assess change in variables of interest in response to ISDN.
Results: Mean age was 23.5 ± 9.2 years (range 11.2-39.0 years), and 10/15 (67%) were male. There was no statistically significant change in peak VO2 (1401±428 to 1428±436 mL/min, p=0.128), but VO2 at the anaerobic threshold increased (1087 + 313 to 1115 + 302 mL/min, p= 0.03). ISDN was also associated with a lower peak exercise PVP (22.5 + 4.5 to 20.6 + 3.0 mmHg, p=0.015). Liver stiffness was lower with ISDN, though the difference was not statistically significant (2.3 + 0.4 to 2.1 + 0.5 m/s, p=0.079). Of the patients completing the trial, mild headache was common (67%), but there were no major adverse events.
Conclusions: Treatment with ISDN for 4 weeks is well-tolerated in patients with a Fontan circulation. ISDN is associated with an increase in VO2 at anaerobic threshold, lower peak PVP, and a trend towards lower liver stiffness. Larger, longer studies will be necessary to define the impact of ISDN on clinical outcomes in the Fontan circulation.
Clinical Trial Registration: URL: https//clinicaltrials.gov. Unique identifier: NCT04297241
Three-Dimensional Echocardiography for the evaluation of Hypertrophic Cardiomyopathy patients: relation to symptoms and exercise capacity
Authors: Cardoso Isabel Machado , Viegas José , Rosa Sílvia Aguiar , Brás Pedro , Grazina André , Cruz Inês , Branco Luísa , Galrinho Ana , Fiarresga António , Lopes Luís R , Ferreira Rui Cruz 
Published: January 2023

Abstract
Purpose: Patients with hypertrophic cardiomyopathy may exhibit impaired functional capacity, associated with increased morbidity and mortality. Systolic function is one of the determinants of functional capacity. Early identification of systolic disfunction may identify patients at risk for adverse outcomes. Myocardial deformation parameters, derived from three-dimensional (3D) speckle-tracking echocardiography (3DSTE) are are useful tools to assess left ventricular systolic function, and are often abnormal before a decline in ejection fraction is seen. The aim of this study was to evaluate the correlation between myocardial deformation parameters obtained by 3DSTE and functional capacity in patients with hypertrophic cardiomyopathy.
Methods: Seventy-four hypertrophic cardiomyopathy adult patients were prospectively evaluated. All patients underwent a dedicated 2D and 3D echocardiographic examination and cardiopulmonary exercise testing (CPET).
Results: Values of 3D global radial (GRS), longitudinal (3DGLS) and circumferential strain (GCS) were overall reduced in our population: 99% (n=73) of the patients had reduced GLS, 82% (n=61) had reduced GRS and all patients had reduced GCS obtain by 3DSTE. Average peak VO2 was 21.01 (6.08) ml/Kg/min; 58% (n=39) of the patients showed reduced exercise tolerance (predicted peak VO2< 80%). The average VE/VCO2 slope was 29.0 (5.3) and 16% (n= 11) of the patients had impaired ventilatory efficiency (VE/VCO2 >34). In multivariable analysis, 3D GLS (β1 = 0.10, 95%CI: 0.03;0.23, p=0.014), age (β1 = -0.15, 95%CI: -0.23; -0.05, p=0.002) and female gender (β1=-5.10, 95%CI: -7.7; -2.6, p<0.01) were independently associated with peak VO2. No association was found between left ventricle ejection fraction obtain and peak VO2 (r=0.161, p=0.5).
Conclusion: Impaired myocardial deformation parameters evaluated by 3DSTE were associated with worse functional capacity assessed by peak VO2.