bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory of suicide as a transformation in obscurity—As told by the deceased's next of kin
Authors: Ovox Säidi Margot , Wärdig Rikard , Hultsjö Sally , Rytterström Patrik 
Published: September 2023

AbstractThere is a collective call from the field of suicide research for studies on the individual dynamics of suicidality in order to understand the deadliness of the suicidal process. This study examines the deceased next of kin's (‘survivor's) experience of the suicidal process in order to gain perspectives that can be used in the preventive care of suicidal patients. The aim of this study was to explore the suicide process through the suicide survivor's experience. The study is designed and conducted through a phenomenological, reflective lifeworld approach. Twelve in‐depth interviews concerning lived experiences of a suicide were conducted. The suicide process is described as the emerging of an obscured transformation of self, and an aligning to this changing understanding of self that forms a unique suicidal death course. This death course contains the co‐occurrence of life and death orientations. Survivors' collected knowledge of a suicidal trajectory helps us understand the life conditions of a suicidal person that has ended their life. Life orientation and experiences of self‐governance are critical parts of a suicidal trajectory and can have great preventive potential for care and assessments during suicidality. The Consolidated Criteria for Reporting Qualitative Research (COREQ) were used for the reporting structure of this article.
Adolescents' satisfaction with abortion services received and factors associated with satisfaction at reproductive health centres
Authors: Amoah Elizah , Enos Juliana Yartey , Ganle John , Maya Ernest Tei 
Published: September 2023

AbstractAimThis study assessed adolescents' satisfaction with services received during their most recent abortion and the factors associated with satisfaction at reproductive health centres in the Greater Accra region of Ghana.DesignA facility‐based cross‐sectional survey was used for this study.MethodsOverall, 254 adolescent girls aged between 15 and 19 years, who had an abortion within 1 week of the study period were recruited for the study. All the 254 respondents were recruited consecutively as they visited health facilities for abortion services from March 2019 to February 2020. Written informed consent was signed by respondents, and data were collected using the Patient Satisfaction with Nursing Care Quality Questionnaire, and the data were analysed using Stata version 15.0. Univariate, bivariate and multivariate logistic regression analyses were conducted.ResultsA majority of adolescents reported being satisfied with the abortion services they received. Ample waiting space and the system of ‘first‐come‐first‐served’ were the highest rated elements of service satisfaction. Adolescents were least satisfied with the inadequacy of instructions and lack of information on medications received and their therapeutic or side effects. Ethnicity, having a stable intimate partner and perceived adequacy of staff were the factors associated with satisfaction with abortion services.ConclusionAdolescents are unique group of people with peculiar health needs. If they are treated with respect and dignity, they are likely to be satisfied with services received from the reproductive health centres offering comprehensive abortion care.ImpactThe study addresses adolescent satisfaction with abortion care received; if health providers treat adolescent seeking abortion care with respect, friendly and non‐judgemental attitude, it will enable adolescents to seek abortion care from qualified professionals instead of unskilled service providers to reduce maternal mortality.Patient's contributionPatients from 11 reproductive centres responded to the questionnaire used for the data collection.
Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor‐alpha signalling
Authors: Sun Tzong‐Bor , Huang Kuo‐Feng , Niu Ko‐Chi , Lin Cheng‐Hsien , Liu Wen‐Pin , Yeh Chao‐Hung , Kuo Shu‐Chun , Chang Ching‐Ping 
Published: September 2023

AbstractRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age‐related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen–glucose deprivation (OGD)‐induced IR‐injured RPE cells. RPE cells were treated with HBO (100% O2 at 3 atmospheres absolute for 90 min) once a day for three consecutive days before retinal IR onset. Compared with normal cells, the IR‐injured RPE cells had lower cell viability, lower peroxisome proliferator activator receptor‐alpha (PPAR‐α) expression, more severe oxidation status, higher blood‐retinal barrier disruption and more elevated apoptosis and autophagy rates. HBO preconditioning increased PPAR‐α expression, improved cell viability, decreased oxidative stress, blood‐retinal barrier disruption and cellular apoptosis and autophagy. A specific PPAR‐α antagonist, GW6471, antagonized all the protective effects of HBO preconditioning in IR‐injured RPE cells. Combining these observations, HBO therapy can reverse OGD‐induced RPE cell injury by activating PPAR‐α signalling.
Effect of exercise after a deep venous thrombosis: A systematic review
Authors: Rook B. , van Rijn M. J. E. , Jansma E. P. , van Montfrans C. 
Published: September 2023

AbstractPost‐thrombotic syndrome (PTS) is a common complication after deep vein thrombosis (DVT) and has a major impact on physical symptoms, quality of life (QoL) and economic costs. Relatively simple lifestyle interventions as physical exercise might reduce PTS severity and increase QoL. To evaluate the direct and long‐term effects of physical activity in patients with an acute or previous DVT. We conducted a systematic review through an additional search from 2007 up to March 2022, to complement the comprehensive systematic review of Kahn et al. Articles evaluating the effect of exercise after a DVT including symptoms, QoL and the incidence and severity of PTS, were included. Quality of the studies was assessed using a GRADE‐like checklist and results were reported according to the PRISMA Statement. Ten studies were included, seven randomized controlled trials and three cohort studies. We identified three types of physical activity based on timing and duration; (1) early mobilisation in the acute phase of the DVT; (2) short duration exercise 1 year after DVT and (3) prolonged exercise during follow‐up after a previous DVT. Early mobilisation showed improvement in QoL and pain reduction and after 2 years it resulted in a significant reduction of PTS severity. Prolonged supervised exercise resulted in improvement of QoL. In addition, positive effects on symptoms of venous insufficiency and muscle functions were observed. None of the included studies reported an increased risk of PTS or worsening of symptoms due to physical activity. Physical exercise after a DVT is safe, improves QoL, reduces pain and decreases PTS severity. Lifestyle intervention such as guided individualized training programs can be a useful supplementary therapy for patients after a DVT or for PTS patients. Optimal training programs may be identified by further studies that improve patient‐oriented outcomes for both adults and children after a DVT.
Comparison of specificity and sensitivity of diagnostic methods for Enteromyxum leei and Enteromyxum fugu detected from cultured tiger puffer, Takifugu rubripes in Korea
Authors: Lee Young Juhn , Jun Lyu Jin , Kim Ye Ji , Han Ji Eun , Ko Ye Jin , Oh Yeong Eun , Lee Eung Joon , Lee Jehee , Jeong Joon Bum 
Published: September 2023

AbstractEnteromyxum leei and Enteromyxum fugu, which are myxosporean parasites, were first found in cultured tiger puffer Takifugu rubripes in Korea. We collected four tiger puffers that showed severe emaciation signs for our experiments. DNA sequencing was confirmed that the tiger puffers were coinfected with E. leei and E. fugu. Furthermore, similar amounts of E. leei and E. fugu were confirmed using real‐time PCR in the intestine. To the best of our knowledge, there have been no reports of E. fugu infection in the olive flounder Paralichthys olivaceus. However, the diagnosis of inflowing water, discharged water and olive flounder samples using highly sensitive diagnostic methods confirmed the presence of E. fugu in water and fish samples from olive flounder farms near the tiger puffer farm. Therefore, the present study aimed to develop highly sensitive diagnostic methods such as real‐time and two‐step PCR for early diagnosis and follow‐up of the emaciation disease and multiplex PCR for rapid diagnosis. The multiplex PCR method exhibited the same sensitivity as the one‐step PCR method developed in this study, demonstrating its efficacy for rapid diagnosis. Therefore, the suggested methods can be utilized for the early diagnosis and rapid diagnosis of emaciation diseases and reduction of economic losses through rapid disease control.
The interplay of metabolic dysfunction‐associated fatty liver disease and viral hepatitis on liver disease severity: A large community‐based study in a viral endemic area
Authors: Huang Chung‐Feng , Liang Po‐Cheng , Tsai Pei‐Chien , Wei Yu‐Ju , Huang Ching‐I , Wang Chih‐Wen , Jang Tyng‐Yuan , Yeh Ming‐Lun , Hsu Po‐Yao , Hsieh Ming‐Yen , Lin Yi‐Hung , Dai Chia‐Yen , Chuang Wan‐Long , Huang Jee‐Fu , Yu Ming‐Lung 
Published: September 2023

AbstractBackground and AimThe prevalence of metabolic dysfunction‐associated fatty liver disease (MAFLD) and its interplay with hepatitis B virus (HBV) and hepatitis C virus (HCV) in terms of liver disease severity is elusive.MethodsA mass surveillance program was conducted in a viral hepatitis endemic area. The objective was to identify MAFLD/non‐MAFLD subjects with advanced liver disease.ResultsTwo thousand two hundred and forty‐two (41.7%) of the 5378 subjects were identified as having MAFLD, and 375 (7.0%) had advanced liver disease. The proportions of anti‐HCV and HBsAg seropositivity were 19.3% and 9.7%, respectively. The proportions of advanced fibrosis in subjects with non‐viral hepatitis (NBNC), HBV and HCV infection were 2.8%, 5.7% and 23.4%, respectively. Subjects with MAFLD had a significantly higher proportion of advanced fibrosis (8.7% vs 5.7%, P < 0.001). Factors associated with advanced fibrosis included age (odds ratio [OR]/95% confidence interval [CI]: 4.8/3.7–6.0, P < 0.001), male sex (OR/CI: 1.3/1.0–1.7, P = 0.019), anti‐HCV seropositivity (OR/CI: 5.9/4.6–7.5, P = 0.019), MAFLD‐lean metabolic dysregulation (MS) (OR/CI: 2.6/1.3–5.2, P = 0.005; compared with the non‐MAFLD group) and MAFLD‐diabetes (OR/CI: 1.5/1.1–2.1, P = 0.008; compared with the non‐MAFLD group). MAFLD did not aggravate liver disease severity in patients with viral hepatitis. However, among NBNC subjects, factors associated with advanced liver disease included MAFLD‐lean MS group (OR/CI: 9.1/2.4–34.6, P = 0.001; compared with non‐MAFLD group) and MAFLD‐DM group (OR/CI: 2.0/1.2–3.2, P = 0.004; compared with non‐MAFLD group).ConclusionsMAFLD patients with diabetes and metabolic dysregulation had a higher risk of advanced liver disease. The effect was more significant in non‐viral hepatitis subjects in a community level.
Career development in pragmatic clinical trials to improve care for people living with dementia
Authors: Gabbard Jennifer , Sadarangani Tina R. , Datta Rupak , Fabius Chanee D. , Gettel Cameron J. , Douglas Natalie F. , Juckett Lisa A. , Kiselica Andrew M. , Murali Komal Patel , McCarthy Ellen P. , Torke Alexia M. , Callahan Christopher M. 
Published: September 2023

AbstractThe growing number of people living with dementia (PLWD) requires a coordinated clinical response to deliver pragmatic, evidence‐based interventions in frontline care settings. However, infrastructure to support such a response is lacking. Moreover, there are too few researchers conducting rigorous embedded pragmatic clinical trials (ePCTs) to make the vision of high quality, widely accessible dementia care a reality. National Institute on Aging (NIA) Imbedded Pragmatic Alzheimer's disease and Related Dementias Clinical Trials (IMPACT) Collaboratory seeks to improve the pipeline of early career researchers qualified to lead ePCTs by funding career development awards. Even with support from the Collaboratory, awardees face practical and methodological challenges to success, recently exacerbated by the COVID‐19 pandemic. We first describe the training opportunities and support network for the IMPACT CDA recipients. This report then describes the unique career development challenges faced by early‐career researchers involved in ePCTs for dementia care. Topics addressed include challenges in establishing a laboratory, academic promotion, mentoring and professional development, and work‐life balance. Concrete suggestions to address these challenges are offered for early‐career investigators, their mentors, and their supporting institutions. While some of these challenges are faced by researchers in other fields, this report seeks to provide a roadmap for expanding the work of the IMPACT Collaboratory and initiating future efforts to recruit, train, and retain talented early‐career researchers involved in ePCTs for dementia care.
Effectiveness of the Kaufman Brief Intelligence Test in people with Prader–Willi syndrome
Authors: Jaime M. P. , Gerk A. , Stegmann J. 
Published: September 2023

AbstractBackgroundEvaluating intelligence using conventional tools is very complex in patients with Prader–Willi Syndrome (PWS), as it is time consuming and requires levels of care that are difficult to sustain for this population. Therefore, we explore the ability of a brief test to assess intelligence in these patients.MethodsThis study included individuals with a genetically confirmed diagnosis of PWS, with regular attendance at transdisciplinary treatment in an institution dedicated to the care of rare diseases in Argentina. The Wechsler Intelligence Scale for Children (WISC‐IV), the Wechsler Adult Intelligence Scale (WAIS‐III) and the Kaufman Brief Intelligence Test (K‐BIT) were used.ResultsCorrelation was obtained between the scales in paediatric and adult populations. Within the paediatric population, no significant differences were identified between the WISC‐IV scale (Wechsler for paediatrics) and the K‐BIT (56.4 ± 8.6, vs. 53.4 ± 10.1, P = 0.28), with a good agreement between the methods {intraclass correlation 0.79 [95% confidence interval (CI) 0.15–0.95]}. Regarding the adult population, the discrimination of the WAIS‐III scale (Wechsler for adults) and the K‐BIT of adults (16 years and over) presented an acceptable concordance [0.77 (95% CI −0.09; 0.93)], although also underestimating the results (58.3 ± 7.2 vs. 51.1 ± 11.2, P < 0.0001).ConclusionsWe observed the feasibility and potential usefulness of a brief intelligence test (K‐BIT) in patients with PWS with an acceptable agreement with conventional tools.
Investigation of cardiopulmonary parameters, motor development and muscle strength in children with Down syndrome with and without congenital heart disease
Authors: Siyah T. , Saglam M. , Yagli N. V. , Ertugrul I. , Aykan H. H. , Karagoz T. 
Published: September 2023

AbstractBackgroundChildren with Down syndrome (DS) frequently have concomitant clinical problems. There are no studies in the literature evaluating gross motor development and handgrip strength in the presence of congenital heart disease (CHD), which is one of the most common comorbidities in population with DS. The aim of this study was to compare cardiopulmonary parameters, gross motor development and handgrip strength in children with DS with and without CHD.MethodsA total of 28 children with DS (14 with CHD and 14 without CHD) were evaluated. Demographic data and cardiopulmonary parameters were recorded. Gross motor development and handgrip strength were assessed.ResultsChildren with DS and CHD had lower GMFM‐88 scores and right handgrip strength and higher Wang respiratory score than children with DS and no CHD (P < 0.05). GMFM‐88 scores were moderately correlated with resting oxygen saturation (r = 0.46, P = 0.01) and right handgrip strength (r = 0.67, P < 0.001).ConclusionsPeripheral muscle strength and oxygen saturation may be factors affecting gross motor development in children with DS. From this point of view, evaluating cardiopulmonary parameters, motor development and handgrip strength in children with DS and CHD is important to identify risks, provide early intervention and support development.
The influence of dietary diversity on anthropometric status among young children ages 12 and 24 months in Wuhan, China
Authors: Xu Qianqian , Zhong Chunrong , Tan Tianqi , Lin Lixia , Yang Hongying , Xu Zhiyong , Yang Nianhong 
Published: September 2023

AbstractThe relative research on investigating the association between dietary diversity scores and anthropometric status among young children is few and inconsistent. Since understanding this association is quite essential to give more detailed advice about diet to ensure young children's healthy growth, we sought to determine the association between dietary diversity levels and anthropometric status among young children under 24 months. The study included 1408 mother−child pairs from the Tongji Maternal and Child Health Cohort, whose children range in age from 12 to 24 months. Multivariable logistic regressions were used to examine the effect of dietary diversity on children's anthropometric failure and obesity. All obese children aged 12 and 24 months had low‐medium diverse diets in their first year of life. Risks of anthropometric failure for 12‐month young children consumed low‐medium diverse diets in their first year and 24‐month young children consumed low‐medium diverse diets in their second year are, respectively, 1.27 (odds ratio [OR], 95% confidence interval [CI] = [1.06−1.53]) and 1.19 (OR, 95% CI = [1.02−1.40]) times of those who consumed high diverse diets in corresponding year. The risk of anthropometric failure for 24‐month‐old children who consumed low‐medium diverse diets during their first year of life is 4.70 (OR, 95% CI = [1.62−19.91]) times that of young children who consumed highly diverse diets during their first year of life. Introducing more diverse diets to young children under 24 months of age may be an effective strategy to prevent anthropometric failure and obesity in young children in later life.
Evidence on the prevalence of emerging and re‐emerging tick‐ and flea‐borne rickettsial agents in acute encephalitis syndrome endemic areas of northeast Uttar Pradesh, India
Authors: Candasamy Sadanandane , Ayyanar Elango , Devaraju Panneer , Kumar Ashwani , Zaman Kamran , Bhaskar Mishra Bhuwan , Srinivasan Lakshmy , Purushothaman Jambulingam 
Published: September 2023

AbstractOutbreaks of acute encephalitis syndrome (AES) with unknown aetiology are reported every year in Gorakhpur district, Uttar Pradesh, India, and Orientia tsutsugamushi, the rickettsial pathogen, responsible for scrub typhus has been attributed as the primary cause of AES problem. However, information on the prevalence of other rickettsial infections is lacking. Hence, this study was carried out to assess any occurrence of tick‐ and flea‐borne rickettsial agents in villages reporting AES cases in this district. In total, 825 peridomestic small mammals were trapped, by setting 9254 Sherman traps in four villages with a trap success rate of 8.9%. The Asian house shrew, Suncus murinus, constituted the predominant animal species (56.2%) and contributed to the maximum number (87.37%) of ectoparasites. In total, 1552 ectoparasites comprising two species of ticks and one species each of flea and louse were retrieved from the trapped rodents/shrews. Rhipicephalus sanguineus, the brown dog tick, was the predominant species retrieved from the trapped rodents/shrews, and the overall infestation rate was 1.75 per animal. In total, 4428 ectoparasites comprising five tick species, three louse species and one flea species were collected from 1798 domestic animals screened. Rhipicephalus microplus was the predominant tick species collected from the domestic animals. The cat flea, Ctenocephalides felis, constituted 1.5% of the total ectoparasites. Of all the ectoparasite samples (5980) from domestic animals and rodents, tested as 1211 pools through real‐time PCR assays, 64 pools were positive for 23S rRNA gene of rickettsial agents. The PCR‐positive samples were subjected to multi‐locus sequence typing (MLST). In BLAST and phylogenetic analysis, the ectoparasites were found to harbour Rickettsia asembonensis (n = 9), Rickettsia conorii (n = 3), Rickettsia massiliae (n = 29) and Candidatus Rickettsia senegalensis (n = 1). A total of 22 pools were detected to have multiple rickettsial agents. The prevalence of fleas and high abundance of tick vectors with natural infections of rickettsial agents indicates the risk of transmission of tick‐ and flea‐borne rickettsial diseases in rural villages of Gorakhpur. Further epidemiological studies are required to confirm the transmission of these agents to humans.
Myelin oligodendrocyte glycoprotein antibody‐associated disease presenting with dystonia
Authors: Zveik Omri , Benoliel Berman Tal , Keadan Tarek , Barhum Khalil , Rechtman Ariel , Vaknin‐Dembinsky Adi 
Published: September 2023

AbstractMyelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) commonly presents as optic neuritis or transverse myelitis. We report an atypical clinical presentation for MOGAD in a 28‐year‐old female experiencing right‐arm dystonic episodes. MRI scans demonstrated multifocal periventricular and subcortical lesions, including in the left centrum semiovale and corona radiata. Despite the atypical presentation, her clinical, serological, and radiographic features favor a MOGAD diagnosis. This report emphasizes the heterogeneity of MOGAD phenotypes and the need to consider MOGAD, even in a non‐typical presentation.
Thromboembolic complications after COVID‐19 in kidney transplant recipients
Authors: Artan Ayse Serra , Dirim Ahmet Burak , Yavuzkilic Halil , Demir Erol , Oto Ozgur Akin , Guller Nurana , Safak Seda , Yazici Halil , Turkmen Aydin 
Published: September 2023

AbstractAimIncreased venous thrombosis and arterial embolism rates are observed in the general population during or after COVID‐19. Data regarding the kidney transplant population are scarce. In this study, we aim to investigate the thrombotic complications and risk factors associated with thrombotic complications in kidney transplant patients.MethodsThis retrospective observational study included adult kidney transplant recipients diagnosed with COVID‐19 between March 2020 and June 2022. The endpoint was the occurrence of thromboembolic events.ResultsFour hundred and sixty‐nine patients were followed for a median of 10.8 months after COVID‐19. Forty patients (8.5%) died. Thromboembolic complications developed in 51 (11.9%) of the surviving patients. Twenty‐four patients with thromboembolic events were receiving prophylactic anticoagulation before the event. The patients with mild, moderate, and severe COVID‐19 were 292, 129, and 48, respectively. Patients with moderate COVID‐19 had a significantly higher percentage of thromboembolic complications than patients with mild COVID‐19. Older age, prior heart disease, and moderate COVID‐19 were significantly associated with thromboembolic events. The incidence of thromboembolic events after COVID‐19 is 10.9 per 100 patient‐year.ConclusionThromboembolic complications were observed at increased rates in kidney transplant recipients after COVID‐19. Therefore, prospective and cohort studies for post‐COVID‐19 complications regarding the treatment modalities are urgently needed.image