bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Nephroprotective Activity of PippalyadiAgad on Diclofenac Sodium Induced Nephrotoxicity in Albino Mice: An Experimental Study
Authors: Gatfane Rupali Y , Sole Sushant S , Patil Smita , Ware Rajashri A , Denge Kalpana S 
Published: May 2023

Background: Nephrotoxicity due to Diclofenac Sodium can be correlated with this concept of Dushi Visha and nephroprotective drugs mentioned in Ayurveda texts may play an important role in this area. Pippalyadi Agad is the herbo-mineral medication stated by Yogaratnakara for treatment of Dushi Visha. Some of the drugs in this formulation have shown efficacy in correcting nephrotoxicity. Objective: To study the nephroprotective activity of Pippalyadi Agad on diclofenac sodium induced nephrotoxicity in albino mice. Methods: The experimental study was carried out in albino mice as per CPCSEA guidelines after getting approval from the Institutional Animal Ethics Committee (IAEC). 30 albino mice, each weighing about 20-30 gm, were procured from Bharat serum and vaccines. The mice were housed in the institutional animal house in standard conditions. 30 albino mice were equally divided into five groups having six animals in each group as Trial Drug (low dose), Trial Drug (medium dose), Standard Control, Disease Control and Vehicle Control. For assessment of nephrotoxicity, the animals were monitored on Day 0, Day 15 and Day 45 by carrying out blood investigations such as BUN, Serum Creatinine, Body weight and CBC. The Data were subjected to appropriate statistical tests to derive results. Results: Pippalyadi Agad treatment at low and medium doses significantly lowered BUN and Serum Creatinine in comparison with Disease and Standard Control at Day 45. Pippalyadi Agad treatment at low and medium doses significantly (p < 0.001 and p < 0.001) increased body weights of the animals in comparison with Disease and Standard Control at Day 45. No significant difference in CBC parameters was observed in any of the Groups except the Disease Control Group on Day 15 and Day 45. Conclusion: Pippalyadi Agad has shown nephroprotective activity based on biochemical changes observed in Serum Creatinine, BUN and CBC.
Efficacy of Palashgudavarti and Diclofenac Sodium Suppository in the management of Acute fissure in ano
Authors: Biswas Shubham Golokkumar , Dasar Devyani , Jaivarshaa Pavithra 
Published: May 2023

Introduction: Parikartika is most common ano-rectal disorder. The text of parikartika is mentioned in Samhitas. In this disease there are symptoms such as bleeding per rectum, hard stools, burning sensation around anal region. In this trial, group A (n=30) included Palashadigudavarti, whereas group B included Diclofenac sodium suppository for administration over Parikartika (acute anal fissures). Gandharva haritaki choorna acts as laxative and helps to relieve constipation and sitz bath was given to both group as conservative management.. Materials and method: Literary aspect of the study was collected from classical Ayurvedic and contemporary text and updated with recent medical journals, previous research work done on same topic. Observation and results: Assessment was done by the parameters such as pain, bleeding and itching as Subjective and healing as Objective Parameter. Results were obtained by statistical analysis. Discussion: In this research work Palash, Goghrita and Beewax as suppository base was used in the form of varti application (advanced anal Suppository) for managing Anal fissure. There is need of ayurvedic suppository easily available in market which will relieves anorectal symptoms instantly, because repeated use of diclofenac sodium have side effect to the body. In the present case series, it proved to be significant in managing Fissure in ano, it reduced pain, itching, bleeding and promoted healing. Conclusion: In the treatment of Parikartika, Palashadigudavarti was more effective than Diclofenac sodium suppository
Keywords: Parikartika, fissure in ano, Palashadigudavarti, Diclofenac Sodium Suppository.
A narrative review on genotoxic potential of medicinal plants used in Ayurveda
Authors: Raj Asha S , Acharya Rabinarayan , Patel Bhupesh R , Pawar Sharad 
Published: May 2023

Genotoxic substances are those which are capable to induce a destructive effect on a cell’s genetic material. It can be either carcinogen, mutagen, teratogen or cytotoxic depending upon the dose, duration and mode of usage. Mutations may manifest in many forms as duplication, deletion or insertion. However, all mutagens are genotoxic, not all genotoxins induce mutations. Currently traditional medicines and plant drugs are used across the globe without strict medical supervision. In a country like India, folklore medicines play a pivot role in health sector. Irrational long-term usage of any plant-based drug are capable to induce adverse reactions. Till date there is no single hand information about the genotoxic effects of medicinal plants used in Ayurveda. Many of the drugs reported for toxicity are potent drug candidates in Ayurveda. From the available literature 184 articles reported the genotoxicity of medicinal plants. After shortlisting with the inclusion and exclusion criteria’s 57 articles are found to be on genotoxic potential of medicinal plants. Present review reports genotoxic effect of 32 drugs used either as single or combination. It contains various array of drugs, for example poisonous drugs like Arka, Dhattura, Mandookaparni – which is a medhya rasayana, Guduchi – which is a potent immunomodulator and so on. Among them a few drugs like Palandu, Tanduleeyaka, Misreya, Chandrasoora, Sariba, Manjishta, Dadima, Guduchi etc. need special attention. This article tries to provide an insight on the reported genotoxic effect of plants used in Ayurveda.
Impact of Yoga therapy on hormonal imbalance in women with Polycystic Ovarian Disease
Authors: Ch Renuka Devi , N Jhansi Rani 
Published: May 2023

The current study aims to evaluate the impact of yoga therapy on hormonal imbalance in PCOS affected women. An empirical study was conducted on 25 women having been diagnosed with PCOS condition. The study used pre and post design. Before starting allopathic medication participants were explained about yoga therapy and participants in the study voluntarily agreed to participate in this study without using medication. Written consent was obtained from the participants. Testosterone, Prolactin, Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), were selected as dependent variables for this study. Before introducing the yoga therapy intervention, baseline hormonal values were collected through blood tests. All the 25 participants practiced yoga protocol specially designed for PCOS condition, for a duration of 12 weeks. At the end of 12 weeks the participant took the blood test in the laboratory for hormonal levels of PCOS related hormones selected for this study. Baseline data was compared with Post data. The impact of yoga therapy on the hormonal imbalance was statistically analysed through paired t-test. The statistical analysis yielded following t values: Serum Testosterone 21.52 (P <0.001), Serum Prolactin 22.13 (P<0.001), Serum LH 30.10 (P<0.001), and Serum FSH 14.16 (P<0.001). The impact of yoga therapy intervention on hormones related to PCOS condition was found to be significantly positive. The results imply that regular yoga practice can be an effective therapy for women with PCOS, especially for correcting imbalance in hormone levels related to PCOS.
Comparative evaluation of Cranberry extract mouth rinse, Ozonized water and 0.2% Chlorhexidine on salivary Streptococcus mutans and Lactobacilli count: An in-vivo study
Authors: Madhu Priyanka Paul , GM Prashant , PG Naveen Kumar , VH Sushanth , Imranulla Mohammed , H Vivek 
Published: May 2023

Background: Cariogenic bacteria has always been considered as the highest risk factor for dental caries. The eradication of microorganisms from the oral health environment is important and hence may remedies have been suggested for its removal for a better oral health.
Objectives: To assess the minimal inhibitory concentration (MIC) of Cranberry extract and to determine the efficacy and compare the effect of the three products on salivary Streptococcus Mutans count and lactobacilli count.Materials and Methodology: A randomized control, double blind, parallel-group clinical trial was conducted on 75 subjects of age group of 15 years who were divided into three study groups ,Cranberry , Ozonized water and Chlorhexidine mouthwash. Microbial analysis was done by colony counter unit at baseline, 8thday and 15th day of using the mouthwashes. The inter-group variations was analyzed by using One way ANOVA followed by Tukey’s post hoc and Repeated measures for intra-group variations at different time intervals.
Results: Streptococcus mutans and Lactobacilli colony count showed a statistically highly significant difference in reduction of colony count between the three groups (p=0.001) at 8th and 15th day of using the mouthwashes. Ozonized water showed better reduction when compared with Cranberry mouth wash in reduction of Streptococcus mutans count. Cranberry mouth wash had shown a better reduction when compared with Ozonized water in reduction of Lactobacilli colony count.Conclusion: The test mouthwash was effective in reducing the microbial count, similar to Chlorhexidine mouth wash. Recent advances may allow the dental community to be exposed to much better oral health care.
key words : cranberry, ozone water, streptococcus mutans, lacto bacilli, oral hygiene
Anti-obesity effect of peel of Opuntia joconostle Web in high-fat-diet-induced obesity C57BL/6J mice
Authors: Perez Gutierrez Rosa Martha 
Published: May 2023

Obesity is directly associate to cancer, diabetes, cardiovascular diseases and hypertension producing severe complication of health and economic costs in a global scale. This study aims to validate the anti-obesity potential of the peel of Opuntia joconostle hydroethanolic extract (XOCO) on obesity in high-fat diet (HFD)-induced obese C57BL/6 mice. Therefore, the phenolic compounds and flavonoids profiles were investigated by colorimetric assay. We are using a HFD induced obesity in mice and after orally administered 200, 300 and mg/kg XOC for 5 weeks. At the end of the experimental period was determined body weight, food intake, serum biochemical parameters, fat weight, organ and a histological analysis. This research demonstrated that the peel of the investigated xoconostle had a significantly amount of flavonoids, showing highest level of total phenolic compound (58.15 mg GAE/g of extract) and flavonoid content (59.12 mg CE/g of extract). XOC Treatment in HFD-fed mice decreases adipogenesis, total body fat, the absolute body weight, lipidemia, glucose levels, leptin, and resistin, and increases HDL-CHO levels and adiponectin. In histological analysis showed inhibition of the deposition of fat droplets in the liver. Findings indicated that XOC has anti-obesity effects in obesity-induced mice. This potential anti-obesity effect may be due to phenolic compounds content in the extract.
Hubungan Pola Asuh Demokratis Orang Tua Dengan Percaya Diri Siswa Kelas VIII SMP Negeri 1 Perbaungan Tahun Ajaran 2021/2022
Authors: Dina Hidayati Hutasuhut Riska Yunanda, 
Published: May 2023

Orangtua memiliki tanggung jawab terhadap anak-anaknya dalam hal Pendidikan. perhatian orangtua baik dari segi moral maupun materi merupakan salah satu factor yang menumbuhkan semangat belajar anak.Penelitian ini bertujuan untuk mengetahui Hubungan Pola asuh Demokratis Dengan percaya diri siswa Kelas VIII SMP Negeri 1 Perbaungan Tahun Ajaran 2021-2022. Metode dalam penelitian ini adalah kuantitatif dengan pendekatan korelasi. Populasi dalam penelitian ini adalah Siswa Kelas VIII SMP Negeri 1 Perbungaan Tahun Ajaran 2021-2022 yang berjumlah 118 siswa, dan teknik pengambilan sampel dalam penelitian ini adalah Teknik Purposive sampling. Peneliti menggunakan Teknik ini karena peneliti ingin menentukan siswa yang mendapatkan pola asuh otoriter dari orang tuanya. Peneliti dapat menentukan sample yang mendapatkan pola asuh otoriter dari orang tuanya adalah dengan membagikan angket pola asuh otoriter yang sudah valid,apabila hasil skor dari penyebaran angket tersebut tinggi maka siswa tersebut dijadikan sampel berjumlah 65 siswa. Instrument pegumpulan data yang digunakan dalam penelitian ini adalah angket. Angket telah diuji Validitas dan Reliabilitasnya, yaitu dengan hasil 36 butir angket yang valid pada angket pola asuh otoriter dan 35 butir angket yang valid pada angket minat belajar. Teknik uji korelasi yang menggunakan rumus korelasi product moment,dari hasil perhitungan diperoleh koefisien korelasi antara Pola asuh otoriter (X) dengan Minat belajar (Y) sebesar rhitung = 0,721 > rtabel = 0,250 . Sesuai dengan interpretasi indeks korelasi product moment maka angka tersebut menunjukkan adanya hubungan antara kedua variabel. Hasil dari pengujian ini menyatakan bahwa terdapat hubungan yang signifikan antara Pola asuh otoriter dengan Minat belajar Siswa Kelas VIII SMP Negeri 1 Perbaungan Tahun Ajaran 2021-2022.
Upaya Meningkatkan Kemampuan Berpikir Kritis Siswa Melalui Model Pembelajaran Deep Dialogue/ Critical Thinking (DD/CT) Pada Mata Pelajaran Fiqih Kelas VIII MTS N 1 Langkat
Authors: Usmaidar, Rani Febriyanni Siti  Darmawani, 
Published: May 2023

This study aims to determine the critical thinking skills of students in Fiqh learning after the application of the Deep Dialogue / Critical Thinking (DD / CT) Learning Model in class VIII MTs N 1 Langkat. This research is included in class action research (Action Research). This study uses a type of collaborative model, namely researchers with Fiqh study teachers in class VIII MTs N 1 Langkat. The subjects in Class Action Research VIII are students of class VIII MTs N 1 Langkat with a total of 32 students. the instruments in this researcher are observation sheets and tests in accordance with the research procedures by observing cycle I and cycle II. The application of the Deep Dialogue/Critical Thinking learning method can be implemented well through two cycles. This can be seen through the activities of students in cycle I and cycle II have increased. The results of observations of student activity in learning which initially in cycle I only reached a score of 67.5% then increased by 17.5% to 85% in cycle II. There is a difference in the critical thinking skills of students in class VIII MTs N 1 Langkat between before and after the implementation of class action research using the Deep Dialogue / Critical Thinking learning method, this is known from the completeness of learning in class VIII MTs N 1 Langkat in the pre-cycle is 66.71% while in cycle I reached 72.96% and in cycle II amounted to 80.93% . After the application of the Deep Dialogue / Critical Thinking learning method, students' critical thinking skills have increased, this can be seen from the results of the pre-cycle critical thinking skills test which only reached an average score of 66.71 (less) and increased in cycle I to 72.96% (sufficient) and in cycle II increased again to 80.93% (good). The increase in critical thinking skills can also be seen in the increase in the percentage of student completeness, namely in the pre-cycle only 40.62% while in cycle I it reached 65.62% and in cycle II it was 84.37%. In addition, from the test results it is known that in cycle I and cycle II the Sig (2- Tailed) value is 0.000. <0.05, it can be concluded that there is a significant difference between the pre-test and post-test learning outcomes. Therefore, it is concluded that the use of the Deep Dialogue/Critical Thinking method can improve students' critical thinking skills.
Pengaruh Minat Murid, Sokongan Ibu Bapa dan Kompetensi Guru Terhadap Penglibatan Murid dalam Aktiviti Kokurikulum
Authors: Micheal Sheila 
Published: May 2023

Kajian ini bertujuan untuk mengenal pasti hubungan dan pengaruh minat murid, sokongan ibu bapa dan kompetensi guru terhadap penglibatan murid dalam aktiviti kokurikulum sekolah menengah di Sabah. Kajian kuantitatif ini mengaplikasikan kaedah tinjauan dan menggunakan borang soal selidik untuk memungut data daripada 492 murid sekolah menengah sebagai sampel. Data tersebut dianalisis menggunakan perisian IBM-SPSS-AMOS 25. Analisis deskriptif menunjukkan minat murid, sokongan ibu bapa, kompetensi guru dan penglibatan murid dalam aktiviti kokurikulum berada pada tahap tinggi. Ujian Korelasi Pearson pula menunjukkan wujudnya hubungan positif yang signifikan antara minat murid (r=0.114, p<0.05), sokongan ibu bapa (r=0.620, p<0.01) dan kompetensi guru (r=0.263, p<0.01) dengan penglibatan murid dalam aktiviti kokurikulum. Analisis Laluan SEM menunjukkan bahawa minat murid dan sokongan ibu bapa mempunyai pengaruh yang signifikan. variabel bebas tersebut mampu meramal penglibatan murid dalam aktiviti kokurikulum pada kadar 62%. Menerusi analisis SEM, kajian ini juga berjaya membangunkan satu cadangan model penglibatan murid dalam aktiviti kokurikulum yang menggabungkan variabel bebas tersebut sebagai faktor utama kepada penglibatan murid dalam aktiviti kokurikulum. Dapatan-dapatan kajian ini adalah bukti empirikal bahawa penglibatan murid dalam aktiviti kokurikulum dapat ditingkatkan menerusi minat murid, sokongan ibu bapa dan kompetensi guru. Oleh itu, hasil kajian ini diharap boleh menjadi panduan kepada semua pihak yang terlibat secara langsung atau tidak langsung dalam sistem pendidikan sekolah menengah dan mampu meningkatkan penglibatan murid dalam aktiviti kokurikulum pada masa yang akan datang.
Recommendations for improving Quality of Research in Medical Institutes
Authors: Mughal Arsalan Manzoor 
Published: May 2023

Research output from Pakistan is gradually increasing. The “Pakistan Research and Innovation Landscape Report” states that research output from Pakistan has increased three hundred times in the Web of Science Core Collection. Among the disciplines, the largest number was from Clinical Medicine and its Normalized Impact is greater than the World average. This achievement is due to a large number of medical colleges in the country. Pakistan currently has 114 medical colleges which are the fifth largest in the world after India, Brazil, China, and the United States of America.
The Launch of JUCMD
Authors: Malik Shahid Mahmud 
Published: May 2023

I have been asked by my editorial team to write a small note for the first issue of this journal entitled, JUCMD (Journal of University College of Medicine and Dentistry). Reflecting on what makes a good journal great reminds of the sayings of Dr Bartosz Hudzik, a young cardiologist at a medical university in Poland. First and foremost, there is the team of dedicated and highly qualified editors who provide valuable guidance on the journal contents. In addition, there are manuscript authors, equally important as the editors, as they are the ones conducting research, writing and rewriting drafts, and submitting the manuscript in hopes that it will be published. Then, there are the reviewers, who advise the editors on the importance and novelty of the findings and the soundness of the research methodology. Finally, there are the readers, who look to the journal for accurate and up-to-date scientific and clinical information. We have this exact recipe right at the start of our journal in the form of a very active and energetic editorial board and a competent pool of reviewers.
Causes of Mortality in Preterm Neonates Admitted in a Tertiary care Hospital in Sahiwal, Punjab - A Retrospective Study.
Authors: Lail Raees Abbas , Aziz Muhammad Aamir 
Published: May 2023

Objective: To find out the factors causing mortality in preterm neonates admitted at a tertiary care hospital in Sahiwal, Punjab.
Method: This retrospective study was conducted in the Pediatric unit of Sahiwal Teaching Hospital, Sahiwal, Punjab, from January to September, 2021. Out of 1256 neonates, including 586 preterm, only those 105 preterm neonates were included in the study who had expired within one month of their stay, were less than 33 weeks of age and had less than 2500 grams birth weight. Their data was analyzed for age and weight at the time of admission, sex, duration of stay and cause of admission. The record of their clinical and radiological investigations was retrieved to know the causes of mortality.
Results
More than half of the deaths amongst 105 preterm neonates were unavoidable and occurred within first 48 hours of hospitalization due to their critical condition at the time of admission. Out of the total deaths, 46 (43.80%) were due to sepsis, 24 (22.85%) were due to birth asphyxia, 24 (22.85%) were due to respiratory distress, 8 (7.61%) were due to neonatal jaundice and 3 (2.85%) deaths had no definite cause.
Conclusion: Neonatal infections are the leading cause of death, followed by birth asphyxia and respiratory distress in the government hospitals of Pakistan. Although the government has made tremendous efforts in the recent years to upgrade the prenatal health services, there is need to further educate the masses and enhance the reach and quality of primary health care services in the district and rural areas of the country.
Prevalence of Hepatitis B and C, Tuberculosis, and Human Immune Deficiency Virus among injection drug users of Punjab, Pakistan-A cross sectional study
Authors: Nawaz Rabia , Shakoor Hira , Shahid Muhammad , Ahad Ammara , Sabri Sabeen , Ajmal Anum , Mehmood Uqba , Riaz Haroon , Rehman Faisal Ur , Akhtar Sohail , Rehman Amir , Rasheed Rizwan , Kabir Muhammad Usman , Jabeen Alina , Sharif Mukarram 
Published: May 2023

Objective: To determine prevalence and factors associated with various infectious diseases such as Hepatitis B, Hepatitis C, HIV, and Tuberculosis, among injection drug users (IDUs), from different rehabilitation centers in several cities of Punjab region in Pakistan.
Methods: This study was conducted between September, 2019 – September, 2020. Total 78 rehabilitation centers were contacted, out of which 21 responded and 57 didn't, even after having focus group discussions with the centers’ administrators. Centers contacted were chosen randomly over various cities of Punjab; with Lahore, Multan, Faisalabad, Gujranwala being major focus. A predesigned questionnaire with several open and closed ended questions was filled via interviewing each rehabilitation center administrator/staff to collect data for the study.
Results: We found a prevalence of 7.96% for HBV, 9.61% for HIV, 0.82% for TB, and the highest 32.69% for HCV amongst the surveyed cohort.
Conclusion: It is concluded that prevalence of infectious diseases in injection drug users is significantly higher than overall reported incidence, thus needs proper disease surveillance and mitigation programs on national level.