bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of longitudinal trajectories of triglyceride-glucose index on the new-onset non-alcoholic fatty liver disease
Authors: Wu Xinri , Chen Quan , Zhang Caiqin , Hong Xin 
Published: January 2025

Abstract

Background The
triglyceride-glucose (TyG) index is a reliable marker of insulin resistance and has been linked to various metabolic disorders. Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic liver disease,especially among the elderly. The relationship between changes in the TyG index and NAFLD onset is not fully understood. Our study examines the association between changes in the TyG index and the onset of NAFLD among elderly participants.
Method
We conducted a prospective cohort study involving 28,535 elderly participants, selected based on their participation in annual health checkups from 2018 to 2021 and having complete triglyceride and fasting blood glucose values, which met our inclusion criteria. The group-based trajectory model was used to identify three distinct TyG trajectory groups: the low-stable group, moderate-stable group, and high-stable group. The incidence of NAFLD in each group was followed up at the 2022 and 2023 checkups. We calculated the differences in cumulative incidence of TyG across the groups and utilized Cox proportional hazard models to estimate risk ratios and 95% confidence intervals for NAFLD onset among the groups. To further minimize the influence of other risk factors on the results, those with BMI > 28 and those taking medications were excluded, respectively, and the models were adjusted for sensitivity analysis. Restricted cubic spline regression was applied to evaluate the baseline dose-response relationship between the TyG index and NAFLD.
Results
The study included a total of 28,535 participants, comprising 13,456 males (47.16%) and 15,079 females (52.84%). The cumulative incidence rates of NAFLD were 7.10% in the low-stable group, 16.10% in the moderate-stable group, and 23.20% in the high-stable group, increasing significantly with rising TyG trajectories (P < 0.001). Cox proportional hazards modeling after adjusting for confounders such as age, sex, blood pressure, BMI, blood glucose, and lipids showed that the risk of NAFLD in the moderate-stable group and the high-stable group was 1.682 (95% CI: 1.541–1.835) and 2.279 (95% CI: 1.998–2.599) times higher than that of the low-stable group (P < 0.001).NAFLD risk progressively increased with higher TyG levels, with critical cut-off values set at 8.56 for the total population.
Conclusion
People with consistently high TyG levels have a higher risk of developing NAFLD, and this risk increases progressively as TyG levels rise.
Modulation of Biofilm Growth by Shear and Fluctuations in Turbulent Environments
Authors: Pizzi Federico , Peters Francesc , Sorribes Elena , Marín-Beltrán Isabel , Romera-Castillo Cristina , Grau Joan , Rahmani Mona , Jofre Lluís , Capuano Francesco 
Published: January 2025

Abstract

This work investigates the role of shear and turbulent fluctuations on multi-species biofilm growth. The study is mostly motivated by understanding biofouling on microplastics (MPs) in oceanic environments. By increasing particle stickiness, biofilms promote MP aggregation and sinking; therefore, a thorough understanding of this multi-scale process is crucial to improve predictions of the MPs fate. We conducted a series of laboratory experiments using an oscillating-grid system to promote biofilm growth on small plastic surfaces under homogeneous isotropic turbulence with grid Reynolds numbers between 305 and 2220. Two configurations were analyzed: one where plastic samples move along with the grid (shear-dominated) and another one where the samples are kept fixed downstream the grid, thus experiencing turbulence but no mean flow (shear-free). Biofilm formed in all cases in a time scale of days, then the biomass formed on the plastic pieces was carefully measured and analyzed as a function of the turbulence level. The shear-free results were further interpreted using a parsimonious physical model, coupling the nutrient uptake rate within the biofilm (Monod kinetics) with the turbulent diffusion of the surrounding bulk liquid. Results show that: (i) under shear-dominated conditions, the biofilm mass initially grows with turbulence intensity before decaying, presumably due to shear-induced erosion; (ii) in the shear-free experiments, the mass increases monotonically following an enhanced availability of nutrients, and then saturates due to uptake-limited kinetics. This latter behavior is well reproduced by the physical model.Furthermore, a subset of plastic pieces were analyzed with a scanning electron microscope, revealing that turbulence also affects the microscopic configuration of biofilm clusters, increasing their compactness as the amplitude of turbulent fluctuations increases. These results contribute not only to our fundamental understanding of biofilms under flow, but can also inform global models of MP transport in marine environments.
Prospective Analysis of Adiposity Metrics for Complicated Acute Colonic Diverticulitis: Should Wses Classification and Visceral Adiposity Be Integrated for Predictive Analyses?
Authors: BEYAZADAM Damla , EREN Tunc , AKGUL Nuray COLAPKULU , SAGIROGLU Sukriye Julide , GUNDUZ Nesrin , EKINCI Ozgur , ALIMOGLU Orhan 
Published: January 2025

Abstract

Background: Colonic diverticulitis is correlated with age, body mass index (BMI), and increased visceral or subcutaneous fat. Obesity contributes to diverticulosis, diverticulitis and its complications onset, as visceral fat activates inflammatory pathways that exacerbate these conditions. The aim of this study was to evaluate the association of visceral adiposity and body mass index (BMI) on complications of acute colonic diverticulitis.
Method: A prospective cohort study was conducted on patients with acute diverticulitis admitted to the general surgery ward of a university hospital in Istanbul from September 2017 to February 2022. A total of 208 patients were classified into uncomplicated and complicated diverticulitis per the World Society of Emergency Surgery guidelines. After documenting demographic, clinical, and laboratory data, along with BMI and computed tomography measurements of visceral and subcutaneous fat areas (VFA, SFA), we conducted a statistical analysis to assess the relationships between VFA, SFA, and BMI in both groups.
Results: Complicated diverticulitis group was found to have significantly lower values of BMI and VFA (p=0.037 and p=0.046 respectively). Similarly, BMI and VFA values of patients who underwent all interventional procedures including percutaneous drainage and surgery were found to be significantly lower than the conservative treatment group (p=0.007, p=0.025 respectively).
Conclusion: Our study shows that complicated diverticulitis cases have lower BMI and visceral fat area. We suggest that increased visceral adipose tissue may serve a protective role by preventing these diverticula from developing into more complicated forms. Therefore, visceral adiposity metrics can be integrated in the predictive analyses.
Rootstock microbiome as a target for manipulation to combat apple replant disease
Authors: Yurgel Svetlana N. , Ajeethan Nivethika , Ali Shawkat 
Published: January 2025

Abstract

Apple replant disease (ARD) describes a phenomenon of reduction of crop productivity in the early years of orchard establishment in the sites previously planted to apple. Currently manipulation of soil microbiome by (bio)fumigation is the major approach to alleviate ARD. Adjustment of rootstock microbiome to harsh orchard soil biotic factors might be an alternative approach to combat ARD. In this study we evaluated differences in microbiome structure and composition between nursery rootstock and mature trees, grown in Nova Scotian apple orchards. We showed that mature apple tree roots possessed microbiome that dramatically differed in its diversity, structure and composition from that associated with saplings. Our research pointed to a single mycorrhizal fungus, Pteridiospora spinosispora, which should be further investigated as a potential nursery inoculum to prevent ARD development in re-planted apple orchards. The results of this study provide a foundation for development of a synthetic community which could be used in nurseries during rootstock propagation to improve saplings adaptation to ARD soils. This approach could deliver an ecologically safe and cost-efficient alternative to soil amendments to alleviate ARD consequences.
Epidemiology and treatment of musculoskeletal injuries in Mass Casualty Incident: a retrospective series from the pagers’ detonation in Lebanon
Authors: Zalaket Jad , Achkouty Andrea , Kais Sami , Mansour Toni , Roukoz Sami , Abiad Rami El 
Published: January 2025

Abstract

Purpose: On September 17, 2024, a coordinated detonation of pagers across multiple regions in Lebanon caused a devastating mass casualty event, resulting in over 2800 injuries and 9 fatalities. Most of the affected individuals suffered from severe hand and eye injuries. This study aims to describe the experience of the Orthopedic Department at anonymous and the treatment strategies that were adopted.
Material and Methods: A retrospective review was conducted to analyze the musculoskeletal injuries sustained during this incident .Data collection included demographic data such as age and gender. Specific factors concerning musculoskeletal injuries such as hand dominance, unilateral or bilateral lesions, injury severity, surgical intervention, missed fractures and need for secondary surgeries were noted as well. Associated injuries, ocular penetrations, ear-drum perforations, brain contusions, intracranial hemorrhage, and facial fractures were also included.
Results: 45 patients (43 males and 2 females) with musculoskeletal injuries were included in this study. Age ranged from 4 to 59 years with a mean of 34 +/- 9.7 years. The most common musculoskeletal trauma was a hand injury with 42 out of 45 patients, including 25 affected bilaterally totalizing 67 injured hands. Other musculoskeletal injuries included 10 deep wounds to the lower limbs, 2 iliac bones fractures and 3 forearm penetrating wounds, one of them causing an ulnar nerve palsy. Kirschner-wires were used in 10 hands initially and post operative X-Rays revealed 15 missed injuries, out of them, 6 underwent secondary surgeries.
Conclusion:Mass causality incidents present a significant and unique challenge for healthcare workers particularly in the field of orthopedic surgery. Lessons learned from such events are critical to improve preparedness and optimize patient care in future encounters.
Association Between Bone Mineral Density, Sleep Disturbance and Sleep Duration: Results from Observational and Mendelian randomization study
Authors: Chen Renqiang , Deng Zihao , Yang Zilong , Xu Jian , Liu Zhiqin 
Published: January 2025

Abstract

Purpose
The relationship between bone health and sleep problems still remains controversial across different study conditions. This study aims to investigate the association between sleep disturbance, sleep duration and bone mineral density(BMD) using observational and Mendelian randomization(MR) study.
Methods
A total of 6,421 participants from the National Health and Nutrition Examination Survey (NHANES) 2007–2010 were included in this study. The association between sleep disturbance, sleep duration, and BMD was assessed using multivariable linear regression analysis. Two-sample MR analysis was employed to corroborate the observational study results. Five methods were utilized to estimate causal effects, with the primary approach being the inverse variance-weighted (IVW) analysis.
Results
Sleep disturbance exhibited a negative association with BMD in both the femoral neck (β: -0.03; 95% CI, -0.04 to -0.02), and lumbar spine (β: -0.01; 95% CI, -0.02 to 0.00). This association remained significant after adjusting for known confounders, with β values of -0.01 (95% CI, -0.02 to -0.01) for the femoral neck and − 0.01 (95% CI, -0.02 to 0.00) for the lumbar spine. No significant association was observed between sleep duration and BMD, and stratification analysis by sleep disturbance yielded similar results. MR analysis appeared to indicate a consistent trend in the causal association between sleep disorder and BMD at the femoral neck using IVW methods (β: -0.039; 95% CI: -0.142 to 0.063), and lumbar spine(β: -0.041; 95% CI: -0.182 to 0.101), and the other 4 methods showed consistent results, although no significant difference was observed. There was no statistical difference found in the MR analysis for the causal relationship between BMD and sleep duration.
Conclusions
The study suggests potential causal associations between sleep disorders and a higher risk of bone loss. Additionally, there is no evidence to indicate that extending sleep duration could compensate for bone loss caused by sleep disorders.
Assessment of the impact of lithology on the watertightness of aerated lagoon systems in a Sub-Saharan Africa environment: the case study of an oil factory company in two councils in the Littoral region of Cameroon
Authors: Kamtoh Auguste Landry Kamegne , Mvongo Victor Dang , Defo Célestin , Nguema Paul Fabrice Nguema , Ombolo Auguste 
Published: January 2025

Abstract

This study aimed to assess the impact of soil lithology in the watertightness of aerated lagoon systems in oil factory company in two councils (Dibombari and Edea 1st ) in the Littoral region of Cameroon. Primary data were obtained through sampling and analysing wastewater in the first basin, soils at various depths (3 m, 7 m, 15 m and 21 m) and groundwater after piezometers’ construction. Data processing involved several steps. Firstly, wastewater parameters were compared to soil parameters at three meters. Secondly, the evolution of soil parameters was analysed for each site by calculating pollutant reductions based on lithological sections. Finally, groundwater parameters from both sites were compared. The results showed that the lagoons systems with geotextile membrane, although quite effective, have shortcomings concerning in particular total nitrogen and phosphates. Due to its lithology, the Dibombari site provided better watertightness (final reductions ranging from 99.84% for total organic matter to 27.20% for sulphates) than that of Edéa (final reductions ranging from 97.25% for total nitrogen to 36.40% for sulphates). Laterites, clayed sands, and clays were the soil types with purifying and filtering qualities associated particularly to these reductions of nitrates and phosphates concentrations. Comparing the piezometers’ groundwater highlighted the superior water quality at the Dibombari site, whose characteristics are closer to natural raw water than those at the Edéa site. Combining these soil types with geotextile membranes during the construction of local lagoon basins could enhance water retention, directly protecting groundwater and indirectly offering opportunities for optimizing waterproofing technology.
Fast neural population dynamics in primate V1 captured by a genetically-encoded voltage indicator
Authors: Zhou Jingyang , Chen Yuzhi , Whitmire Matt , Tan Pin Kwang , Wu Jimin , Veeraraghavan Ashok , Robinson Jacob , Geisler Wilson , Pieribone Vincent , Seidemann Eyal 
Published: January 2025

Abstract

Genetically encoded voltage indicators (GEVIs) can measure millisecond-scale subthreshold neural responses with cell type specificity. Here, we successfully expressed, for the first time, a GEVI in excitatory V1 neurons in macaque monkeys. We then used widefield fluorescent imaging to measure V1 dynamics in response to visual stimuli with diverse temporal waveforms and contrasts, and compared these responses to signals measured using a genetically encoded calcium indicator (GECI) and a synthetic voltage-sensitive dye (VSD). When compared to GECI, GEVI captures faster response dynamics, tracks higher temporal frequencies, and responds to lower contrasts. To quantitatively characterize these three signals, we developed a simple nonlinear model that predicts the response dynamics to stimuli with arbitrary temporal waveforms and contrasts. Our results are consistent with the hypothesis that GEVI signals reflect the dynamics of locally summed membrane potentials, thus opening the door for a new class of experiments in behaving primates.
Integration of Conventional and Virtual Reality Approaches in Augmented Reality for Theory-Based Psychoeducational Intervention Design for Chronic Low Back Pain: Scoping Review
Authors: Conen Robin , Mueller Steffen , Tibubos Ana Nanette 
Published: January 2025

Background
Psychoeducation positively influences the psychological components of chronic low back pain (CLBP) in conventional treatments. The digitalization of health care has led to the discussion of virtual reality (VR) interventions. However, CLBP treatments in VR have some limitations due to full immersion. In comparison, augmented reality (AR) supplements the real world with virtual elements involving one’s own body sensory perception and can combine conventional and VR approaches.

Objective
The aim of this study was to review the state of research on the treatment of CLBP through psychoeducation, including immersive technologies, and to formulate suggestions for psychoeducation in AR for CLBP.

Methods
A scoping review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed in August 2024 by using Livivo ZB MED, PubMed, Web of Science, American Psychological Association PsycINFO (PsycArticle), and PsyArXiv Preprints databases. A qualitative content analysis of the included studies was conducted based on 4 deductively extracted categories.

Results
We included 12 studies published between 2019 and 2024 referring to conventional and VR-based psychoeducation for CLBP treatment, but no study referred to AR. In these studies, educational programs were combined with physiotherapy, encompassing content on pain biology, psychological education, coping strategies, and relaxation techniques. The key outcomes were pain intensity, kinesiophobia, pain catastrophizing, degree of disability, quality of life, well-being, self-efficacy, depression, attrition rate, and user experience. Passive, active, and gamified strategies were used to promote intrinsic motivation from a psychological point of view. Regarding user experience from a software development perspective, user friendliness, operational support, and application challenges were recommended.

Conclusions
For the development of a framework for an AR-based psychoeducational intervention for CLBP, the combination of theories of acceptance and use of technologies with insights from health psychological behavior change theories appears to be of great importance. An example of a theory-based design of a psychoeducation intervention in AR for CLBP is proposed and discussed.
Analysis of “Dr Ding Xiang” on WeChat in China to Determine Factors Influencing Readership on Medical Social Media: Observational Study
Authors: Liao Jiaman , Huang Xueliang , Huang Hao , Shen Cuina , Li Lixia , Li Yushao , Zhan Yiqiang 
Published: January 2025

Background
With the rapid expansion of social media platforms, the demand for health information has increased substantially, leading to innovative approaches and new opportunities in health education.

Objective
This study aims to analyze the characteristics of articles published on the “Dr Ding Xiang” WeChat official account (WOA), one of the most popular institutional accounts on the WeChat platform, to identify factors influencing readership engagement and to propose strategies for enhancing the effectiveness of health information dissemination.

Methods
A total of 5286 articles published on the “Dr Ding Xiang” WOA from January 2021 to December 2021 were collected and analyzed. Additionally, a random sample of 324 articles was selected for detailed text analysis. Univariate analysis was conducted using the chi-square test, and multivariate analysis was performed using multivariable logistic regression.

Results
In 2021, the total number of reads for “Dr Ding Xiang” articles reached 323,479,841, with an average of 61,196 reads per article. Articles exceeding 100,000 reads accounted for 33.90% of the total. Most articles were published during the time slots of 8:00-10:00 AM, 11:30 AM to 1:30 PM, and 8:30-10:30 PM. Analysis indicated that the order of publication, style of the title sentence, number of likes, number of in-views, total likes on comments, and number of replies to comments were significantly associated with an article’s number of reads. Text analysis further revealed that the article’s reasoning approaches and concluding methods also had a significant impact on readership.

Conclusions
To enhance readership and the effectiveness of health communication, health-focused WOAs should consider key factors such as optimal publication timing, engaging title design, and effective content structuring. Attention to these elements can improve user engagement and support the broader dissemination of health information.
Impacts of disturbance on ant (Hymenoptera: Formicidae) food preferences and dominance in a Mexican temperate forest
Authors: Zolá-Rodríguez Meghan I. , Cuautle Mariana , Rodríguez-Flores Marco Daniel , Castillo-Guevara Citlalli 
Published: January 2025

This study examines the impact of disturbance on the food preferences and dominance of an ant community in a temperate ecosystem in Mexico. The study focused on 2 types of vegetation: native oak forest and induced grassland (disturbed vegetation). Observations were conducted to record the food elements carried by ants to their nests. These data were analyzed using x2 tests. Tuna and honey baits were placed near the nests to record the presence of ants in 5-minute periods. We used a binomial model to determine whether the probability of finding an ant foraging at the baits was affected by vegetation type, bait type, and/or ant species. Additional baits were used to determine the ant dominance indices. T-tests and ANOVAs were used to compare dominance indices between vegetation types, baits, and ant species. No significant differences were observed in food preferences between vegetations. However, some species showed a preference for honey (i.e., carbohydrates), which could be limited in ground-level environments. Ants showed a submissive behavior in both vegetation types. This research shows that ants could optimize their nutrient intake, enabling them to survive efficiently even when facing disturbances, instead of increasing dominance.
Bases para una Reconstrucción Analítica de la Ontología Conceptual de la Dogmática Jurídica Procesal.
Authors: Cáceres Nieto Enrique , López Olvera Carmen Patricia 
Published: January 2025

El objetivo de este trabajo es criticar los supuestos epistémicos metafísicos y esencialistas de la dogmática jurídica, la forma en la que ésta elabora sus ontologías conceptuales y proponer una metodología analítica alternativa a partir de la Teoría de la Supraregla. El itinerario seguido en la investigación es el siguiente: 1) se elaboró un corpus a partir de las obras de dogmática del derecho procesal mediante el uso del software MAXQDA; 2) a partir de los datos arrojados se obtuvo la muestra de conceptualizaciones que fueron analizadas con el fin de identificar patrones en los supuestos epistémicos y estrategias seguidas para su elaboración; 3) el desarrollo del trabajo inicia con una breve consideración sobre los supuestos epistémicos de la dogmática jurídica; 4) breves consideraciones sobre el giro analítico en filosofía; 5) consideraciones semánticas del término dogmática jurídica; 6) demostraciones de los patrones metafísicos y esencialistas presentes en las conceptualizaciones analizadas y los problemas que traen aparejados; 7) Exposición de la Teoría de la Supraregla; 8) Propuesta metodológica para la reconstrucción analítica de la ontología conceptual de la dogmática del derecho procesal a partir de la Teoría de la Supraregla como una estrategia para contender dicho problema; y, 9) Conclusiones.