bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness of the relative quality of spatial working memory representations
Authors: Li Alison Y. , Sprague Thomas C. 
Published: January 2023

AbstractWorking memory (WM) is the ability to maintain and manipulate information no longer accessible in the environment. The brain maintains WM representations over delay periods in noisy population-level activation patterns, resulting in variability in WM representations across items and trials. It is established that participants can introspect aspects of the quality of WM representations, and that they can accurately compare which of several WM representations of stimulus features like orientation or color is better on each trial. However, whether this ability to evaluate and compare the quality of multiple WM representations extends to spatial WM tasks remains unknown. Here, we employed a memory-guided saccade task to test recall errors for remembered spatial locations when participants were allowed to choose the most precise representation to report. Participants remembered either one or two spatial locations over a delay and reported one item’s location with a saccade. On trials with two spatial locations, participants reported either the spatial location of a randomly cued item, or the location of the stimulus they remembered best. We found a significant improvement in recall error and increase in response time (RT) when participants reported their best-remembered item compared with trials in which they were randomly cued. These results demonstrate that participants can accurately introspect the relative quality of neural WM representations for spatial position, consistent with previous observations for other stimulus features, and support a model of WM coding involving noisy representations across items and trials.
L'après-Brexit reste à écrire
Authors: Ophèle Robert 
Published: January 2023

Le Royaume Uni a recherché de façon constante à bénéficier du « meilleur des deux mondes » dans le secteur financier : l'accès au marché unique et la liberté d'adapter ses réglementations et sa supervision. La renégociation qui a précédé le référendum y parvenait en restant dans l'Union ; dans le cadre du Brexit, l'ambition du Royaume Uni était d'y parvenir en étant hors de l'Union via des accords de reconnaissance mutuelle. L'Union, a refusé de s'engager dans cette voie qui aurait accru sa dépendance en matière financière vis-à-vis de centres de décisions situés dans des pays tiers. On est dès lors dans une situation de concurrence frontale dans laquelle le Royaume Uni s'engage résolument dans une politique de révision du cadre de régulation de son secteur financier pour en accroître, en partie au détriment de l'Union, la compétitivité et l'attractivité via un allégement des contraintes et une flexibilité des réponses réglementaires. De son côté, les marchés financiers de l'Union restent fragmentés et elle peine à améliorer son cadre réglementaire. Le Royaume Uni considère qu'avoir une industrie financière puissante est essentiel, l'Union n'en a jamais fait une priorité. L'après-Brexit reste à écrire, mais il constituera un défi, appelant une prise de conscience de l'urgence de réformes profondes dans l'Union avec la réalisation effective d'une union des marchés de capitaux avec une supervision unique. Classification JEL : F36, F38, F65, G18.
Deuil, vulnérabilité… et coronavirus
Authors: Veyrié Nadia 
Published: January 2023

Résumé : Comment les personnes en deuil ont-elles été vulnérables du fait de la maladie contagieuse du Covid-19 ? Pour répondre, l’auteur propose d’analyser la place symbolique accordée à la vulnérabilité et au deuil, pour ensuite comprendre le deuil de ces personnes pendant la période du premier confinement en France.
Lecture épistémologique de la vulnérabilité : à travers le cas paradigmatique des mères adolescentes
Authors: Mouchtouris Antigone 
Published: January 2023

Résumé : Cette contribution a pour but de saisir l’usage social des notions de vulnérabilité et de dignité individuelle comme marqueur du paradigme de l’accompagnement social. Après avoir tenté de clarifier les conceptions auxquelles ces deux termes renvoient, nous observons que le travail social se dote d’approches de l’intervention qui traduisent une évolution des pratiques centrées sur la personne. La présentation du « Développement du pouvoir d’agir » (DPA) et de l’approche « Dignité dans le soin » permettent de constater un renforcement d’une conception individualiste et relationnelle de la dignité comme réponse aux situations de vulnérabilité.
Increasing the Self-Confidence of School Nurses to Respond to Emergency Situations
Authors: Mattheus Deborah , Fontenot Holly B. , Lim Eunjung , Owens Melissa , Wong Lorrie 
Published: January 2023

Background:
School nurses have various degrees of experience responding to respiratory or cardiac emergencies, and most only receive Basic Life Support training every 2 years as required. The goal of the study was to assess school nurses' confidence and competence in emergency situations before and after engaging in emergency preparedness high-fidelity simulations.

Method:

This mixed methods study used a pre-/postsimulation survey design for a group of school nurses (
N
= 40) in the State of Hawaii. The pre- and postsimulation survey assessed professional demographics and measured confidence. After the presimulation survey, nurses participated in a 1-day training that included two separate emergency simulations using high-fidelity equipment. In addition, education was provided on the program's standardized emergency supply bags with equipment and their use during an emergency. The postsimulation survey was distributed 5 days after the educational intervention.

Results:
All confidence items significantly improved after the simulation session. Nurses noted the value of the training and hands-on simulation experience.

Conclusion:

Simulation is a useful tool for increasing school nurses' confidence in responding to emergencies occurring on school campuses.

[
J Contin Educ Nurs.
2023;54(2):71–77.]
Le contrôle de gestion sociale sous influence des outils big data RH : cas de l’entreprise DIODA
Authors: SYBORD Christine 
Published: January 2023

Toutes les fonctions d’entreprise au cœur des échanges d’informations sont bousculées par les innovations numériques qui transforment nos façons de travailler ensemble. Parti d’un cas de non performance sociale, l’article interroge l’influence des outils big data RH (Ressources Humaines) sur le pilotage du Contrôle de Gestion Sociale (CGS). Pour mesurer cette influence, le cadre d’analyse mobilisé croise les singularités informationnelles de contrôle des outils big data RH avec les deux niveaux du pilotage social : l’opérationnel et le stratégique. Les résultats de cette recherche exploratoire, menée dans le service de CGS de l’entreprise appelée DIODA, montrent que les outils big data RH changent l’échelle d’analyse du pilotage social mais restent sous l’influence de l’organisation des informations RH.
Assessment of Knowledge, Attitude and Practices of Health Care Professionals Working in Jumbo COVID Care Center Towards Mental Health Care Needs: A Cross Sectional Survey
Authors: Andrade Neelam N. , Kshirsagar Minal Madhukar , Andrade Tanvi , Bandgar Vaibhav V. , Pimpale Sandeep , Chavan Ankush 
Published: January 2023

Background:
The present COVID-19 pandemic is a major threat worldwide. Health professionals being within the front line of the COVID-19 outbreak response are at the highest risk of getting infected. Such pandemics are always associated with ill effects on mental health also.

Materials and Methods:
A cross-sectional study included all the health care professionals working in the Jumbo COVID Care Center, Mumbai. Details of health care professionals were obtained from the authority of Jumbo COVID Care Center, Mumbai. Amongst 350 health care professionals, 285 responded (Response rate: 81.42%). A questionnaire, consisting of 19 structured, self-administered, and closed-ended questions, was employed online, and information regarding age, gender, profession, etc., was collected. It was then tabulated and subjected further to an analysis.

Results:
Most health care professionals (96.1%) were aware that COVID-19 is not only affecting physical but mental health too, also posts on social media (86.3%) are affecting mental health more than the actual disease. A total of 95.8% agreed that health care/frontline workers are at the highest risk and felt the need for psychiatrists in the present pandemic. (81.4%) They were also worried thinking about elderly people with comorbidities in their homes. (82.1%).

Conclusion:
From the present study, it can be concluded that the present pandemic is affecting not only physical but mental health also, and there is an increased need for psychiatrists and mental health care professionals to overcome the same.
Prevalence of Substance Use and Assessment of Sleep Quality, Stress, and Anxiety in Police Personnel in the Pandemic
Authors: George Ashika B. , Shetty Jyoti V. 
Published: January 2023

Background:
COVID-19 pandemic has thrown everyone into crisis mode. Lockdowns have affected police personnel, especially as they were working on the ground level. Our study aims to assess the prevalence of substance use and assess the stress, anxiety, and sleep quality among police personnel during the COVID-19 pandemic.

Design:
This design was a cross-sectional study, July–September 2020.

Setting:
This study was conducted at Bharati Vidyapeeth Police Station.

Materials and Methods:
One hundred police personnel were selected at random and interviewed. The Perceived Stress Scale and Symptoms of Stress Scale, the Coronavirus Anxiety Scale, Alcohol, Smoking, and Substance Involvement Screening, and the Pittsburgh Sleep Quality Index were used.

Statistical Analysis:
The collected data were coded and entered in Microsoft Excel sheet, were analyzed using inferential and descriptive analysis as mean, standard deviation, t-test, and Chi-square by Statistical Packages for the Social Sciences version 20.0 software.

Results:
The stress assessed using the SPSS and inferential and descriptive analysis came out to be as follows: 1% with high stress, 33% with moderate stress, and 66% experiencing low stress. The prevalence of CRA was found to be 8%. A total of 31% were found to have some sleep issues. A total of 44% of the police personnel were found to use some substance, with the prevalence of alcohol being 32% and nicotine being 22%. There was no significant association found between anxiety, stress, and sleep quality with substance use in the study. There was no significant relationship found between sociodemographic profile and scores on the scales used.
Efficacy and safety of biosimilar romiplostim in Indian patients with chronic immune thrombocytopenia
Authors: Iqbal Asif , Sharma Chandana , Bora Roslin L. , Phukan Abhijit 
Published: January 2023

Context and Aims:
To evaluate the efficacy and safety of biosimilar romiplostim in Indian patients with immune thrombocytopenic purpura (ITP).

Settings and Design:
Multicentre, retrospective observational study.

Methods and Material:
Patients with chronic ITP who received biosimilar romiplostim from July 2019 to March 2020 across 3 major hospitals in Guwahati, India, were included. The study outcomes were the platelet response (platelet count > 50 × 109/L), time to first response, number of dose-limiting events, and the median effective dose.

Statistical Analysis Used:
Descriptive.

Results:
Of 32 patients included in this analysis, majority (59.4%) were females. The mean (SD) age was 40.37 (15.79) years, and mean age at ITP diagnosis was 38.53 years. The median number of romiplostim doses were 27.5 (range: 10-42) over a period of 10 months; median romiplostim dose used was 4.2 μg/kg (range: 2.8-5 μg/kg). Platelet response was achieved as early as after one week in 9 (28.12%) patients, which continued to increase to 24 (75%) patients after the second, 30 (93.75%) patients after the third and all 32 (100%) patients after four weeks of romiplostim administration. The median platelet count was 161 × 109/L. Dose reduction was done in a total of 21 patients. Thrombocytosis (46.88%), elevated liver enzymes (15.63%) and myalgia (15.63%) were the most common adverse events.

Conclusions:
Biosimilar romiplostim was effective in achieving and maintaining platelet response without any new safety concerns in Indian adult patients with chronic ITP. The median effective dose of romiplostim required in our patients was lower as compared with the standard prescribed dose.
Utility of morphologic assessment of bone marrow biopsy in diagnosis of lysosomal storage disorders
Authors: Nishith Nilay , Siddiqui Saima H. , Raja S. K. R. , Agrawal Neha , Phadke Shubha , Sharma Seema 
Published: January 2023

Introduction:
Lysosomal storage disorders (LSDs) are rare disorders and pose a diagnostic challenge for clinicians owing to their generalized symptomatology. In this study, we aim to classify LSDs into two broad categories, namely, Gaucher disease (GD) and Niemann–Pick/Niemann–Pick-like diseases (NP/NP-like diseases) based on the morphology of the storage cells in the bone marrow (BM) aspiration smears and trephine biopsy sections.

Materials and Method:
This retrospective study includes 32 BM specimens morphologically diagnosed as LSDs at our institute, in the last 10 years. Subsequently, they were subclassified into GD and NP/NP-like diseases. Further, we have compared and analyzed the clinical, hematological, and biochemical parameters for the two groups of LSDs.

Results:
Based on BM morphology, 59.4% (n = 19) cases were diagnosed as NP/NP-like diseases and 40.6% (n = 13) cases as GD. Abdominal distension and failure to thrive were the most common clinical manifestations in both groups of LSDs. Anemia and thrombocytopenia were frequently seen in either of the LSDs. On the assessment of metabolic profile, elevated total/direct bilirubin and liver enzymes were more commonly seen in NP/NP-like diseases when compared with GD.

Conclusion:
We have classified LSDs into GD and NP/NP-like diseases based on the morphology of the storage cells in the BM specimen. The hallmark findings on BM biopsy annexed with the comparative features of the two proposed categories can aid the clinician in clinching the diagnosis. Formulation of such a methodology will prove instrumental for patient care in an underresourced setting.
Cold antibody autoimmune hemolytic anemia following varicella infection
Authors: Carvalho Glennys , D'silva Allen , Chandran Prateesh , Manuel Kevin , Kinglsey  , Basheer Aneesh 
Published: January 2023

Introduction:
Autoimmune hemolytic anemia (AIHA) is a rare complication of chicken pox. In adults, such AIHA is due to warm antibodies. We report a case of cold antibody AIHA following chicken pox in a young female.

Case Report:
A 24-year-old female presented with clinical and laboratory features consistent with hemolytic anemia 5 days after the onset of chicken pox. Her hemoglobin levels dropped rapidly during the course of admission from 7.9 to 3.8 g/dL with evidence of ongoing haemolysis in the form of rising total and indirect bilirubin. Peripheral smear revealed red cell agglutinates and erythrophagocytosis. Direct Coomb's test (DCT) was positive for C3d suggesting a cold antibody AIHA. Since test for Donath Landsteiner antibody was negative, and all other tests for common causes of hemolytic anemia were noncontributory, it was presumed to be due to chicken pox. The fulminant course necessitated a short course of oral steroids to which she responded with rise in hemoglobin and no further hemolysis. Two weeks later, her peripheral smear was normal and DCT negative.

Conclusion:
In patients presenting with acute onset anemia following chicken pox, possibility of cold antibody AIHA must be considered and appropriate testing pursued. Despite lack of empiric evidence, short course of steroids may be beneficial if drop in hemoglobin is rapid with evidence of fulminant hemolysis, showing no abatement after first week.
SARS-CoV-2 induced changes in the lungs based on autopsy cases
Authors: Pencheva Mina Miroslavova , Genova Sylvia Nikolaeva 
Published: January 2023

Context:
Researchers throughout the world devote enormous efforts to reveal the peculiarities of the pathogenesis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, however, it continues to surprise and cause the death of millions of people.

Aims:
This article aims to study the molecular mechanisms provoked by SARS-CoV-2, the virus-induced changes in Angiotensin-converting enzyme 2 (ACE2) functionality, in the vascular homeostasis through CD34 expression, B-cell immunity through the expression of CD20 and CD79α, and adhesion molecules through E-cadherin.

Settings and Design:
This was a prospective, descriptive, and observational study.

Methods and Material:
A total of 15 autopsies of patients deceased by COVID-19 infection, confirmed by PCR, were performed. The lungs of all patients were examined histologically and immunohistochemically for ACE2, E-cadherin, CD34, CD20, and CD79α.

Results:
Immunohistological analysis showed increased ACE2 expression in all lung autopsy material affected by COVID-19 infection and we found a higher intensity of ACE2 expression than that of a healthy lung. CD20 examination reveals total deficiency of B-cells in the pulmonary parenchyma and CD79α is also absent. E-Cadherin is not expressed in the basal cellular sections where the contact elements are missing. CD34 demonstrates a desquamation of the endothelial cells, which indicates a direct damage of the vascular walls.

Conclusions:
We found that patients who died after severe COVID-19 had high immune deficiency and impaired intercellular communication in the parenchyma and endothelium of lung tissue, leading to severe thromboembolic complications in patients with multiple diseases.
Predicting childhood overweight status by accelerated weight gain from neonatal period to infancy
Authors: Koohmanaee Shahin , Badeli Hamidreza , Rad Afagh Hassanzadeh , Novin Mohammad Hassan , Mostofizadeh Neda , Dalili Setila , Kazemnejad-Leili Ehsan 
Published: January 2023

Background:
The increased prevalence of obesity in early childhood is a public health problem. Childhood obesity may affect cardiorespiratory fitness and can induce obesity and its comorbidities in adulthood. We aimed to assess childhood overweight status by accelerated weight gain during infancy.

Materials and Methods:
This is a historical cohort that was conducted on 637 7-year-old students of Guilan province, north of Iran. Data were collected, including demographic characteristics, weight at 4, 6, 12, and 18 months, and clinical examination. The ROC curve was designated based on the standardized z-scores, and the most appropriate cutoff point by sensitivity and specificity was noted for predicting obesity at 7 years. Rapid weight gain (RWG) was also assessed.

Results:
Among participants, 334 (53.3%) were female. In this study, the mean and standard deviation of RWG in 0–4 months, 0–6 months, 0–12 months, and 0–18 months were 3.50 ± 0.89, 4.64 ± 1.02, 6.54 ± 1.21, and 8.00 ± 1.46 kg, respectively. The highest AUC was dedicated to 0–18 months (0.7 ± 0.05) and the suitable cut-off for RWG in this interval was 8.55 kg with 65.5% and 72.0% sensitivity and specificity, respectively.

Conclusion:
Although in the previous investigations, the changes in the first 3 years of life had a significant role in further complications, regarding our results, it seems that even earlier consideration of excess weight gain may be necessary.
Effectiveness of bosentan in the treatment of systemic sclerosis-related digital ulcers: Systematic review and meta-analysis
Authors: Hosseinbalam Marziyeh , Nouri Rasool , Farajzadegan Ziba , Mottaghi Peyman 
Published: January 2023

Background:
The aim of the present systematic review and meta-analysis was to evaluate the therapeutic efficacy of bosentan, a dual endothelin receptor antagonist, for systemic sclerosis (SSc) patients with digital ulcers (DUs).

Materials and Methods:
A systematic search of MEDLINE, Embase, Web of Science, and Scopus was done using appropriate keywords till September 2021. Weighted mean difference (WMD) as the effect of therapeutic efficacy of bosentan on continuous outcomes was an estimate. Furthermore, the pooled prevalence of diffuse SSc and limited SSc was computed. Fixed or random effects models when appropriate were used for data synthesis.

Results:
Totally, 469 patients, with a mean age ranging from 48.1 to 63.7 years, from 8 studies were included in the systematic review and meta-analysis. The pooled frequency of diffuse SSc and limited SSc was 56% (95% confidence interval [CI]: 39%, 73%) and 44% (95% CI: 27%, 61%). The pooled prevalence of new DUs following bosentan treatment was 21% (95% CI: 10%, 33%). The results of the meta-analysis showed a pooled mean decrease of WMD: −0.09 (95% CI: −0.020, 0.02, P = 0.10), WMD: −2.82 (95% CI: −5.91, 0.27, P = 0.07), and WMD: −6.65 (95% CI: −9.49, −3.82, P < 0.001) in mean SSc-Health Assessment Questionnaire, pain, and Rodnan score, respectively. Our meta-analysis also indicated a significant pooled decrease in the number of new DUs in SSc patients compared to placebo subjects (WMD: −0.89 [95% CI: −1.40, −0.37; P = 0.001]) and baseline values (WMD: −1.34 (95% CI: −1.95, −0.73; P < 0.001).

Conclusion:
Bosentan possibly is an efficacious treatment option for SSc-related DUs. Although further large-scale randomized clinical trials are required to confirm the preliminary finding and underlying mechanisms of action.
Availability and nature of cardiac rehabilitation by province in Iran: A 2018 update of ICCPR's global audit
Authors: Sadeghi Masoumeh , Turk-Adawi Karam , Supervia Marta , Fard Mohammad Rafati , Noohi Fereydoun , Roohafza Hamidreza , Sarrafzadegan Nizal , Grace Sherry L 
Published: January 2023

Background:
Cardiac rehabilitation (CR) is scantly available in Iran, although it is the cost-benefit strategy in cardiac patients, It has not been established how CR is delivered within Iran. This study aimed to determine: (a) availability, density and unmet need for CR, and (b) nature of CR services in Iran by province.

Materials and Methods:
In this cross-sectional sub-study of the global CR audit, program availability was determined through cardiovascular networks. An online survey was then disseminated to these programs in June 2016–2017 which assessed capacity and characteristics; a paper-based survey was disseminated in 2018 to nonresponding and any new programs. CR density and need was computed based on annual incidence of acute myocardial infarction (AMI) in each province.

Results:
Of the 31 provinces, 12 (38.7%) had CR services. There were 30 programs nationally, all in capital cities; of these, programs in 9 (75.0%) provinces, specifically 22 (73.3%) programs, participated. The national CR density is 1 spot per 7 incident AMI patients/year. Unmet need is greatest in Khuzestan, Tehran and west Azerbaijan, with 44,816 more spots needed/year. Most programs assessed cardiovascular risk factors, and offered comprehensive services, delivered by a multi-disciplinary team, comprised chiefly of nurses, dietitians and cardiologists. Median dose is 14 sessions/program in supervised programs. A third of programs offered home-based services.

Conclusion:
Where programs do exist in IRAN, they are generally delivered in accordance with guidelines. Therefore, we must increase capacity in CR services in all provinces to improve secondary prevention services.