bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing the Anti‐Vaxxer: Discursive analysis of public deliberations on childhood vaccination
Authors: White Jessica B. C. , O'Doherty Kieran C. 
Published: March 2023

AbstractPublic deliberation is a form of dialogue that allows members of the public to provide input on a policy issue. Public deliberation processes invite participants to engage with each other respectfully, learn about the topic and each other's perspectives, and then work together toward solutions to an issue that are broadly acceptable. In this article, we develop a discursive psychological analysis of public deliberation on the topic of childhood vaccination. In particular, we focus on how descriptions of a parent who did not have her children vaccinated were developed iteratively by a small group of deliberants; how these descriptions came to be accepted as factual; and how these descriptions came to be used to support normative claims about childhood vaccination. Our main argument is that we can develop a deeper understanding of deliberation processes if we understand participants' statements to be rhetorically organised. This is achieved by examining how descriptions of events or people that are relevant to the final conclusions of the group are developed in the course of deliberation; how they come to be accepted as factual and accurate by the group; and how they then become instrumental in supporting a final consensus position.
Prevalence and antibiotic resistance of Aeromonas schubertii causing internal white spot disease on snakehead fish, Channa striata, in the Mekong Delta, Vietnam
Authors: Pham Thi Hai Ha , Kim Do‐Hyung , Quach Van Cao Thi , Nguyen Phuong Thuy , Nguyen Thanh Luan 
Published: March 2023

AbstractSnakehead, Channa striata, has a long history of invasion and associated negative impacts on the biodiversity of native aquatic organisms in the Mekong Delta. However, internal white spot disease caused by Aeromonas schubertii has a massive effect on the production of snakehead fish but also can spread to wild populations and to consumers. The aim of the study was to investigate the prevalence of multi‐antibiotic resistance (MAR) of A. schubertii isolated from snakehead fish cultured in several Mekong Delta fish farms, as well as its potential to spread throughout the infection season. Based on morphological and biochemical tests, as well as phylogenetic analysis of three housekeeping genes (16S rRNA, gyrB, and rpoD), isolates recovered from white nodules were strongly identified as A. schubertii. The antibiotic susceptibility testing revealed that all of the isolates (n = 25) were phenotypically multidrug‐resistant, with resistance to erythromycin (84%), rifampicin (84%), flumequine (88%), amoxicillin (96%), ciprofloxacin (92%), and florfenicol (92%). The multiple antibiotic resistance indices ranged from 0.33 to 0.92, with A. schubertii isolate As28 being resistant against 11 out of the 12 tested antibiotics. In particular, 15 MAR phenotypes (MARPs) were found in 25 isolates with 8 isolates (32%) commonly displaying MAR phenotypes against patterns of Ery–Rif–Flq–Aml–Cip–Flo, and four isolates (16%) expressing patterns of Ery–Rif–Nov–Flq–Aml–Cip–Flo. A hierarchical clustering analysis of their antibiotic‐resistant bacteria may indicate cross‐invasion between ponds/fish farms and its ability to survive in aquatic environments for long periods (at least 3 months). Our results suggest that the diversity of MARPs bacteria in snakehead represents a potential hazard to modifying the composition of native aquatic organisms, especially to consumers. To successfully manage C. striata in the future, several eco‐friendly techniques should be used to restrict the spread of A. schubertii inside the invaded habitat of the Mekong Delta river.
Acoustic ecology of terrestrial mammals: a new Signaller–Receiver Conceptual Framework
Authors: Stein Rachel M. , Rachlow Janet L. 
Published: March 2023

Abstract

Mammals use sound for a variety of purposes, such as detecting the presence of others and maintaining social bonds. Much research on mammalian acoustics has been focussed on marine mammals and bats; less has considered terrestrial species.

Our goal was to review knowledge about the role of acoustics in the behaviour and ecology of terrestrial mammals and to develop a conceptual framework that contextualises the knowledge. The purpose of the framework was to enable researchers to place their work in a broader understanding of the acoustics of terrestrial mammals, as well as to support them to articulate and explore new questions.

We conducted a keyword search in Web of Science and removed papers that did not meet our criteria, resulting in 228 reviewed papers. We scored these for keywords and used concept maps to identify broad patterns.

Of the 228 papers, 219 were focussed on acoustic communication. We therefore structured our Signaller–Receiver Conceptual Framework around factors that influence signallers (i.e. mammals producing sound) and receivers (i.e. mammals receiving sound). Factors that influence signallers were placed into two categories – those that influence call emission and those that influence call structure. Factors that influence receivers also fell into two categories – those that influence detection of sound and those that influence responses to sound. We added an additional receiver category – responses to sound. We present the framework in terms of five types of factors (environmental, social, morphological and physiological, state‐related factors, and other) and how they influence both signallers and receivers.

Our review is the first to detail the range of factors influencing acoustic ecology of terrestrial mammals, and our framework provides context for the articulation of hypotheses that integrate multiple factors, and so can help researchers place their work in a broader context.
A rare case of delayed complete lead dislodgement after deep septal pacing: A hidden risk of the specific procedure
Authors: Watanabe Ryo , Inden Yasuya , Yanagisawa Satoshi , Narita Yuji , Hiramatsu Kei , Yamauchi Ryota , Tsurumi Naoki , Suzuki Noriyuki , Shimojo Masafumi , Suga Kazumasa , Tsuji Yukiomi , Murohara Toyoaki 
Published: March 2023

AbstractDeep septal ventricular pacing is a recently developed physiological pacing modality with good efficacy; however, it has a potential risk of unusual complications. Here, we report a patient with pacing failure and spontaneous, complete lead dislodgement after >2 years of deep septal pacing, possibly caused by systemic bacterial infection and specific lead behavior in the septal myocardium. This case report may implicate a hidden risk of unusual complications in deep septal pacing.
Pediatric chronic urticaria: Clinical and laboratory characteristics and factors linked to remission
Authors: Sandoval‐Ruballos Mónica , Domínguez Olga , Ortiz de Landazuri Iñaki , Gereda Daniella , Espinoza Cisneros Michelle , Quesada Sequeira Fabriella , Ramos Rodríguez Sandra Melissa , Machinena Adrianna , Piquer Mónica , Folqué María del Mar , Lozano Jaime , Jiménez‐Feijoo Rosa , Pascal Mariona , Alvaro‐Lozano Montserrat 
Published: March 2023

AbstractBackgroundChronic urticaria (CU) is defined as the occurrence of wheals/angioedema for ≥6 consecutive weeks. Until now, guidelines and publications addressing CU have focused mainly on adults. As a result, evidence and guidance in the pediatric population are scarce.MethodsThis study aims to describe clinical and laboratory findings in pediatric CU and to determine factors associated with remission.Results185 patients, 54% female, median age at onset of 8.8 years. Angioedema was present in almost half. The most common type of CU was chronic spontaneous urticaria (CSU) in 74%. At least one atopic comorbidity was found in almost a third (35%). In addition, 8% had an autoimmune disorder (exclusively in CSU) and 9% had a psychiatric condition. Basopenia was found in 67% and was more frequently associated with CSU. The basophil activation test (BAT) was positive in 40%. With regard to remission, being of male sex, angioedema absence, the absence of physical triggers, and eosinophil counts >0.51 × 109/L were associated with shorter CU duration.ConclusionAtopy is a common condition in pediatric CU. CSU is the most common type. Autoimmune comorbidities and basopenia were significantly more common in CSU. In addition, ours is one of the few studies, assessing BAT utility in the pediatric population, being positive in a relevant percentage (40%). BAT positivity was more frequent in CSU. Our results suggest that the absence of angioedema and physical triggers, male sex, and eosinophil counts >0.51 × 109/L appear to be associated with a better prognosis in terms of remission.
Long Non‐coding RNA H19‐Overexpressing Exosomes Ameliorate UVB‐Induced Photoaging by Upregulating SIRT1Via Sponging miR‐138
Authors: Gao Wei , Zhang Yue , Yuan Limin , Huang Fangzhou , Wang Yu‐shuai 
Published: March 2023

AbstractUVB‐induced photoaging is characterized by wrinkle formation, slackness and senile plaques, affecting the health and beauty of human being. Our previous study revealed that exosomes derived from adipose‐derived stem cells (ADSCs) could efficiently alleviate UVB‐induced photodamage. However, the functional ingredients in exosomes were undefined. LncRNA H19, one of the well‐researched lncRNAs in exosomes, exhibits multiple physiological effects. This study aims to demonstrate the photo‐protective role of lncRNA H19 on skin photoaging in UVB‐irradiated human skin fibroblasts cells (HSFs) and Kunming mice. LncRNA H19‐overexpressing exosomes (H19‐Exo) were isolated from the supernatant of ADSCs infected with lncRNA H19‐loaded lentivirus. The results showed that H19‐Exo significantly inhibited MMPs production, DNA damage and ROS generation while enhancing procollagen type I synthesis in UVB‐irradiated HSFs. Meanwhile, H19‐Exo markedly reversed epidermal thickening and collagen degradation in UVB‐irradiated mice. Furthermore, luciferase reporter assays indicated that lncRNA H19 acted as a sponge for miR‐138 expression, and SIRT1 was targeted by miR‐138. Evidence from both in vitro and in vivo studies also revealed that H19‐Exo could enhance SIRT1 expression by knocking down miR‐138. In conclusion, lncRNA H19 served as a therapeutic candidate in treating UVB‐induced skin photoaging by upregulation of SIRT1 via miR‐138.
Credit market imperfection, lack of entrepreneurship and capital outflow from a developing economy
Authors: Marjit Sugata , Mishra Suryaprakash 
Published: March 2023

AbstractThis paper explores the impact of credit market imperfection on lack of demand for capital, trade, and capital flows in an economy with wealth heterogeneity. In particular, we look at the implications of wealth heterogeneity. We show that the low return of capital and lower output of credit‐intensive output in autarky may reflect lack of entrepreneurship and demand for credit due to wealth heterogeneity and eventually may lead to capital outflow from a capital‐scarce country. This is a different way of echoing the sentiment of the well–known Lucas paradox, which suggests that capital might flow from the poor to the rich countries. We also show the possibility of trade and capital flow being complements and not substitutes, as is usual in standard trade models driven by factor abundance.
Quantitative simulation of photothermal effect in laser therapy of hypertrophic scar
Authors: Shen Jin Cui , Liang Ya Ya , Li Wei 
Published: March 2023

AbstractBackgroundLaser technology has been widely used in the treatment of hypertrophic scar (HPS). Due to the lack of effective quantitative relationship between laser doses and thermal effect of lesion tissue, the selection of laser doses in clinical laser treatment of HPS is blind, which cannot guarantee the best treatment effect.Materials and methodsThe photothermal model of HPS was established by using finite element method. The effects of laser dose parameters such as laser energy density, pulse width, and spot diameter on the thermal effects of laser treatment were analyzed. According to tissue temperature threshold and thermal damage degree of the simulation results, the optimal laser doses of HPS were selected for the laser treatment experiments of rabbit ear HPSs to verify the rationality of the quantitative photothermal model.ResultsThe temperature rise and thermal damage degree of HPS following laser treatment were directly correlated to the laser doses, which grew with the increase of energy density and laser pulse width. For the different spot diameters, the temperature rise decreased with the increase of spot diameter, whereas the thermal damage degree worsened with the increase of spot diameter. Both simulation and experimental results show that the optimal treatment parameters of HPS were as follows: The laser energy density was 7.5 J/cm3, the pulse width was 4 ms, and the spot diameter was 7 mm.ConclusionThe laser dose parameters optimized by the photothermal model have achieved good therapeutic effects in the rabbit ear HPS, indicating that the model can be used for quantitative evaluation of laser doses before clinical treatment.
Identification of a triatomine infected with Trypanosoma cruzi in an urban area of the state of Veracruz, Mexico: A comprehensive study
Authors: Ochoa‐Martínez Paulina , López‐Monteon Aracely , López‐Domínguez Jaime , Torres‐Montero Jesús , Alberto Domínguez‐Guillén Jorge , Ramos‐Ligonio Angel 
Published: March 2023

AbstractChagas disease, considered a neglected disease, was initially confined to rural localities in endemic areas; however, in recent years through the process of urbanization and migration of infected people, the disease is gaining importance in urban environments. The presence of the vector in urban areas in most cases is due to the passive transport of vectors, but recently, its presence seems to be linked to vector adaptation processes associated with climate change. This paper reports the occurrence of an infected triatomine in the peridomicile of a house in an urban area of Córdoba, Veracruz, Mexico, where the species found is described, the molecular characteristics and resistance to BZN and NFX of the Trypanosoma cruzi isolate obtained, as well as serological data of the dwelling inhabitants. These urban disease scenarios make it possible to generate new scientific knowledge and enable the creation of new control strategies for Chagas disease vectors.
The Effect of Contralateral Knee Neuromuscular Exercises on Static and Dynamic Balance, Knee Function, and Pain in Athletes Who Underwent Anterior Cruciate Ligament Reconstruction: A Single-Blind Randomized Controlled Trial
Authors: Karimijashni Motahareh , Sarvestani Fahimeh Kamali , Yoosefinejad Amin Kordi 
Published: March 2023

Context: Contralateral training in the early stages after surgery can improve the balance of the reconstructed knee, which is impaired following anterior cruciate ligament reconstruction (ACLR). However, little is known about the neuromuscular cross exercise after ACLR. Objective: To investigate the effects of an 8-week cross exercise on balance and function of the reconstructed knee following ACLR. Design: A single-blind randomized clinical trial. Participants: Thirty athletic males who underwent ACLR were randomly divided into intervention (n = 15) and control groups (n = 15). Intervention: The intervention and control groups received a routine physiotherapy program. In addition, the intervention group performed neuromuscular exercises on the nonoperated limb. Outcome Measures: Before and 9 weeks after ACLR, dynamic and static balance, function, and pain in the reconstructed knee were measured by Star Excursion Balance Test (SEBT), stork balance stand test, balance error scoring system (BESS), Lysholm questionnaire, and visual analog scale. Data were analyzed by SPSS using 2-independent sample t test, paired t test, and analysis of covariance. Results: Between-group comparison showed that, contralateral knee neuromuscular exercises significantly increased in the reaching distance in SEBT in the anterior (P < .001), posterior (P < .001), posteromedial (P = .010), and posterolateral directions (P = .007), decreased the number of errors in 4 stance positions of BESS including single stance on the firm (P ≤ .001) and foam surface (P ≤ .001), and tandem stance on the firm (P = .028) and foam surface (P ≤ .001). It also increased the time of standing of the stork stand test (P = .044) and decreased the pain intensity (P = .014). Conclusion: Neuromuscular exercise of the nonsurgical knee could improve the dynamic and static balance, and pain in the early stages following ACLR in the surgical leg. These findings may be potentially valuable for current rehabilitation protocols.
Potential impact on cost-effectiveness estimates of using immature survival data: a case study based on transcatheter edge-to-edge repair (TEER) used for patients with severe mitral regurgitation at high surgical risk
Authors: Connock Martin , Auguste Peter , Capelle Aude , Hénaine Anna-Maria , Obadia Jean-François , Armoiry Xavier 
Published: March 2023

ObjectiveTo review the survival modelling used in cost-effectiveness studies evaluating an interventional procedure and to discuss implications for decision-makers.DesignA case study of three economic evaluations that each used immature data from the EVEREST II High Surgical Risk (HSR) Study of transcatheter edge-to-edge repair (TEER) for patients with severe mitral regurgitation (MR) who were at high risk of surgery.SettingEstimation of patient survival in cost-effectiveness studies.ParticipantsThe EVEREST II HSR Study included 78 patients who had TEER of the mitral valve using the MitraClip device and a retrospectively identified control group of 36 patients who received medical management and were followed up for 12 months. Observed survival (TEER arm only) was updated at 5 years.ResultsTwo studies used 12-month observed mortality from EVEREST II HSR to model survival over lifetime horizons. Observed and modelled survival were associated with considerable uncertainty due to short follow-up and small numbers of participants. Modelling control patients’ survival required an approximate 10-fold extrapolation based on 12-month observation of only 38 patients. Observed 5-year survival in the TEER group differed from that less mature follow-up suggesting that survival modelling based on shorter follow-up was unsatisfactory. No public domain data for the control group are available beyond 12-month follow-up so meaningful estimates using mature data for both arms are currently not possible. A third study developed survival models using incompletely reported transitions between MR grades in EVEREST II HSR and mortality rates observed for different MR grades derived from a study in an unrelated population.ConclusionsModelling survival in such small samples followed up for only 12 months is associated with great uncertainty, and cost-effectiveness results based on these analyses should be viewed as premature and used cautiously in reimbursement decisions.
Healthcare providers’ perceptions and expectations of video-assisted debriefing of real-life obstetrical emergencies: a qualitative study from Denmark
Authors: Rosvig Lena Have , Lou Stina , Hvidman Lone , Manser Tanja , Uldbjerg Niels , Kierkegaard Ole , Brogaard Lise 
Published: March 2023

ObjectivesVideo-assisted debriefing (VAD) of real-life obstetrical emergencies provides an opportunity to improve quality of care, but is rarely used in clinical practice. A barrier for implementation is the expected mental reservations among healthcare providers. The aim of this study was to explore healthcare providers’ perceptions and expectations of VAD of real-life events.SettingParticipants were recruited from two Labour and Delivery Units in Denmark. In both units, VAD of real-life obstetrical emergencies had never been conducted.Participants22 healthcare providers (10 physicians, 9 midwives and 3 nursing assistants). During the study period (August–October 2021), semi-structured, individual interviews were conducted. Interviews were analysed using thematic analysis.Primary and secondary outcome measuresA qualitative description of healthcare providers’ perceptions and expectations of VAD of real-life events.ResultsThree major themes were identified: (1)Video-assisted debriefing (VAD) as an opportunity for learning:All participants expected VAD to provide an opportunity for learning and improving patient care. All participants expected the video to provide a ‘bigger picture’, by showing ‘what was actually done’ instead of ‘what we believed was done’. (2)Video-assisted debriefing (VAD) as a cause for concern:The primary concern for all participants was the risk of being exposed as less competent. Participants were concerned that being confronted with every minor detail of their clinical practice would enhance their self-criticalness. (3)Preconditions for video-assisted debriefing (VAD):Participants emphasised the importance of organisational support from management. In addition, creating a safe environment for VAD, for example, by using only expert debriefers was considered an essential precondition for successful implementation.ConclusionsThe risk of being exposed as less competent was a barrier towards VAD of real-life events. However, the majority found the educational benefits to outweigh the risk of being exposed.
Intravenousferric carboxymaltoseversus oral ferrous sulfate replacement in elderly patients after acute non-variceal gastrointestinal bleeding (FIERCE): protocol of a multicentre, open-label, randomised controlled trial
Authors: Teutsch Brigitta , Váncsa Szilárd , Farkas Nelli , Szakács Zsolt , Vörhendi Nóra , Boros Eszter , Szabó Imre , Hágendorn Roland , Alizadeh Hussain , Hegyi Péter , Erőss Bálint 
Published: March 2023

IntroductionAcute gastrointestinal bleeding (GIB) is a life-threatening emergency with a critical economic burden. As a result of bleeding, anaemia often requires intravenous or oral iron supplementation. Elderly patients are even more prone to untoward outcomes after hospital discharge if iron supplementation is inefficient. There is a gap in current guidelines on which supplementation route clinicians should choose. We aim to investigate the effect of one dose of intravenous iron therapy versus 3-month oral iron administration on anaemia in an elderly population.Methods and analysisThe FIERCE study is an open-label, randomised controlled, two-armed trial. At least 48 hours after the acute non-variceal GIB treatment, patients will be recruited in participating centres. A random sequence generator will allocate the participants to group A (intravenous ferric carboxymaltose, 1000 mg) or group B (oral ferrous sulfate (FS), ca. 200 mg every day) with an allocation ratio of 1:1 on the day of the planned discharge from the hospital. Randomisation will be stratified for participating centres and the need for transfusion within the same hospitalisation before recruitment to the trial. Quality of life assessment, functional measurement and laboratory tests will be performed at baseline, 1 and 3 months±7 days after enrolment to the trial. The primary endpoint is a composite endpoint, including all-cause mortality, anaemia-associated unplanned emergency visit and anaemia-associated unplanned hospital admission within 3 months of enrolment in the trial.Ethics and disseminationThe study has been approved by the relevant organisation, the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (46395-5/2021/EÜIG). We will disseminate our results to the medical community and will publish our results in peer-reviewed journals.Trial registrationThe trial has been registered at ClinicalTrials.gov (NCT05060731).