bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of gustatory dysfunction, olfactory dysfunction, and cognition in older adults
Authors: Mattos Jose L. , Hasan Shahzeb , Schlosser Rodney J. , Payne Spencer C. , Soler Zachary M. 
Published: December 2022

AbstractBackgroundThe association of gustatory dysfunction (GD) with quality of life (QOL) and cognition in older adults is understudied. Our objective was to study the prevalence of GD in the community and explore impacts and associated factors.MethodsA prospective, multi‐institutional, pre‐corona virus disease (COVID) cohort of adults aged 50 years and older had smell and taste testing using “Sniffin’ Sticks” (TDI) and “Taste Strips.” The impact of GD on mood, QOL, and social interaction was assessed through visual analog scales. Subjects completed the Questionnaire of Olfactory Disorders, Patient Health Questionnaire 9, Mini‐Mental State Examination (MMSE), Montreal Cognitive Assessment, and the DeJong scale of loneliness.ResultsA total of 48 patients, average age of 54.7 years, were enrolled. Thirty‐two percent experienced GD on taste strips, and 62% experienced olfactory dysfunction (OD) on TDI. Almost 30% (29.5%) had both GD and OD. GD and OD correlated with worsened cognitive function on MMSE (r = 0.392 and 0.05, p = 0.018 and 0.003). Subjects with both GD and OD had worse MMSE than either alone (p = 0.003). Dry mouth and difficult chewing correlated with GD (r = −0.37 and −0.31, p = 0.10 and 0.37). Self‐reported GD and OD were correlated (r = 0.46, p = 0.001), as were psychophysical GD and OD (r = 0.394, p = 0.008). GD did not correlate with other metrics.ConclusionThirty‐two percent of subjects experienced GD on psychophysical testing, yet most are unaware without impacts on daily life. However, GD correlates with worsened cognitive function. Taste testing may play a role in screening of neurocognitive decline, and multisensory dysfunction may indicate of worsened cognitive states.
Electrochemical Single‐Cell Protein Therapeutics Using a Double‐Barrel Nanopipette
Authors: Shi Xiao‐Mei , Xu Yi‐Tong , Zhou Bing‐Yu , Wang Bing , Yu Si‐Yuan , Zhao Wei‐Wei , Jiang Dechen , Chen Hong‐Yuan , Xu Jing‐Juan 
Published: December 2022

AbstractSingle‐cell protein therapeutics is expected to promote our in‐depth understanding of how a specific protein with a therapeutic dosage treats the cell without population averaging. However, it has not yet been tackled by current single‐cell nanotools. We address this challenge by the use of a double‐barrel nanopipette, in which one lumen was used for electroosmotic cytosolic protein delivery and the other was customized for ionic evaluation of the consequence. Upon injection of protein DJ‐1 through the delivery lumen, upregulation of the antioxidant protein could protect neural PC‐12 cells against oxidative stress from phorbol myristate acetate exposure, as deduced by targeting of the cytosolic hydrogen peroxide by the detecting lumen. The nanotool developed in this study for single‐cell protein therapeutics provides a perspective for future single‐cell therapeutics involving different therapeutic modalities, such as peptides, enzymes and nucleic acids.
Improved cure kinetics of phthalonitrile resins using dicyanamide‐based ionic liquids
Authors: Wolfgang Josh D. , Dysart Jennifer L. , Laskoski Matthew 
Published: December 2022

AbstractPhthalonitrile (PN) polymers are high‐temperature thermosetting resins with excellent thermal and mechanical performance, but they exhibit notably long cure‐times hindering their use in certain applications. Ionic liquids (ILs) and aromatic amines provide an opportunity to cure at lower temperatures and shorter times. Dicyanamide‐based ILs are an interesting class of high‐temperature organic salts due to their high thermal stability and –CN functionality. The addition of ionic liquid in concentrations of 10 and 20 wt% enabled a decrease of the crossover modulus by 30 and 45°C, respectively. When the samples were mixed with both 3 wt% of an amine curing additive and the ionic liquid, the temperature of the crossover modulus was decreased even more dramatically with cure temperatures up to 96°C below that of the PN resin without additives. The differential scanning calorimetry results support the rheological findings that the ILs decrease the temperature and/or time required to cure PN resins. Herein, a dicyanamide‐based ionic liquid catalyzed the curing of PN resins by lowering the gelation temperature by up to 40°C, decreased the processing viscosity by five‐ to eight‐fold, and increased the density of the resin thermosets by nearly 3% on average.
Carbon nanotubes/cellulose composite aerogels with controllable microstructure for electromagnetic interference shielding
Authors: Li Ying , Shi Qin , Peng Longgui , Chang Mengjie , Zhou Fang , Gong Changdan , Wu Yi , Zhang Liangqing 
Published: December 2022

AbstractIn this work, isotropic cellulose aerogels with microstructure from three‐dimensional (3D) sheet‐networks to 3D nanofibrous networks are obtained by adjusting the tertiary butanol content and using the homogenous freezing method. When changing the freezing method to unidirectional freezing, the microstructure of cellulose aerogels transforms from isotropic to oriented fibrous network structure. The mechanical performance of cellulose aerogels presents microstructure‐dependent behavior. Furthermore, serviceable conductivity and electromagnetic interference (EMI) shielding performance are imparted to cellulose aerogels by uniformly dispersing carbon nanotubes (CNTs) into cellulose matrixes. With the same CNT content (10 wt%), oriented CNTs/cellulose composite aerogels show higher EMI shielding efficiency (EMI SE) than that of isotropic composite aerogels. One possible reason is that oriented composite aerogels can reflect and absorb the electromagnetic waves much more times along the freezing direction. The specific SE (716 dB cm3 g−1) of oriented composite aerogel is higher than that of isotropic composite aerogel (539 dB cm3 g−1), which is the reason that oriented composite aerogel has lower density and higher SE. These advantages of lightweight, controllable microstructure, adjustable EMI shielding performance give CNTs/cellulose composite aerogels broad application prospects in the field of EMI shielding.
Modulating the Morphological Features of Hydrothermally Derived Nickel Cobaltite for Supercapacitor Application: Role of Precursor Anions
Authors: Girija Nimisha , Kuttan Surya Suma , Gopakumar Gopika Kavitha , Nair Balagopal N. , Mohamed Abdul Azeez Peer , Hareesh Unnikrishnan Nair Saraswathy 
Published: December 2022

AbstractMorphologically engineered porous electrodes show great promise in energy applications as they exhibit improved electrochemical activity owing to increased electrical conductivity, increased surface area, and a shorter path length for ion transport. Herein, the role of precursors (chlorides, acetates and nitrates) on the crystallinity and textural features of Nickel Cobaltite, obtained by the controlled precipitation through hydrothermal synthesis, is studied. The synthesis yielded urchin like structures with morphological variations in substructures based on the precursor anion types. The surface area values obtained for nickel cobaltite derived from the chloride (NCO‐C), nitrate (NCO‐N), and acetate precursors (NCO‐A) were 30,110 and 115 m2 g−1, confirming the influence of anions on the textural features. The time dependant electrolyte (2 M KOH) infiltration behaviour on the electrode surfaces based on contact angle measurements is invoked to correlate its morphological and textural attributes with the electrolyte transport kinetics. The electrochemical performances were derived from cyclic voltammetry, galvanostatic charge discharge analysis and impedance measurements. The electrolyte infiltration studies established a dependence on the precursor anion. NCO‐A facilitated faster electrolyte infiltration time of 7800 ms compared to 16200 ms and 54,000 ms for NCO‐N and NCO‐C electrodes, respectively. Furthermore, NCO‐A exhibited a greater specific capacitance of 802 F g−1 than NCO‐N (500 F g−1) and NCO‐C (342 F g−1). The morphology modulation coupled with optimal porosity led to conducive pathways for reversible electrolyte infiltration resulting in increased capacitive contribution in NCO‐A. The study revealed that the size of intercalating anions exercised a significant impact on the morphological and electrochemical features, signifying the importance of synthetic approaches in determining the functional properties of electrode materials.
Symbol or substance? Scrutinizing the ‘risk transparency premise’ in marketized sustainable finance: The case of TCFD reporting
Authors: Di Marco Roberta , Dong Ting , Malatincová Ria , Reuter Marek , Strömsten Torkel 
Published: December 2022

AbstractContemporary forms of “marketized” sustainable finance rely on the production, dissemination, and consumption of financialized ESG risk information. In this paper, we scrutinize this “risk transparency premise” in context of the TCFD's climate risk reporting framework. Adopting the lens of institutional theory and a mixed methods approach, we pursue two interrelated aims. First, we examine to which extent the climate risk disclosures of TCFD “supporters” from the European financial sector adhere to the information requirements spelled out in the TCFD framework. Second, we seek to uncover the organization level impediments that underlie substantive implementation of the TCFD framework and, in turn, the production and dissemination of the required climate risk information. Based on our findings, we argue that TCFD/climate risk reporting is prone to become a ‘ceremonial’ practice and that, at least as of now, the ‘institutional myth’ of risk transparency might rather serve to safeguard the ideals of the market as opposed to facilitate transformative change towards a more environmentally sustainable economy. Our findings complement research that has problematized contemporary forms of marketized sustainable finance as well as literature on climate risk reporting and TCFD more specifically.
Antioxidant and Antidiabetic Properties of Extracts from Three Underutilized Food Plants of North East India
Authors: Goswami Manab Jyoti , Dutta Utpal , Seema Tage , Bharali Sourav Jyoti , Yanka Hage , Tag Hui , Bharali Pankaj , Kakati Dwipen 
Published: December 2022

AbstractThree underutilized leafy vegetables Sarcochlamys pulcherrima (Roxb.) Gaudich (SP), Ipomoea aquatica Forssk. (IA) and Zanthoxylum rhetsa (Roxb.) DC (ZR) were extracted with different solvents viz. 95 % ethyl alcohol, methanol and hot water. The extracts were evaluated for their antioxidant potential via DPPH, ABTS and FRAP assay along with electroanalytical studies using cyclic voltammetry. The antidiabetic potential was determined by recording their α‐amylase and α‐glucosidase inhibitory assay. The total phenolic content (TPC), total flavonoid content (TFC) and the liquid chromatography‐mass spectrometry (LC/MS) based phytochemical profiles of the extracts were also determined. All three extracts of SP exhibited significant antioxidant capacity. The antidiabetic potential of the IA and ZR extracts was found to be higher than or at par with that of standard acarbose. LC/MS studies reveal the presence of hitherto reported antioxidant and antidiabetic compounds like gamma‐aminobutyric acid, cinnamic acid, caffeic acid, α‐viniferin, piperlonguminine, niacin, kaempferol, etc., in the extracts.
Klebsiella pneumoniae sepsis complicated with central nervous system involvement: A case series
Authors: Inoue Ken , Hikone Mayu , Oishio Masato , Noji Saki , Sugiyama Kazuhiro 
Published: December 2022

AbstractCentral nervous system (CNS) infection with Klebsiella pneumoniae can be a complication of invasive liver abscess syndrome; however, CNS infections due to K. pneumoniae without liver abscesses are rare. We report three fatal cases of CNS infection due to K. pneumoniae that lacked liver abscesses during the initial investigation.
Tuning Electronic Structure of CuCo2O4 Spinel via Mn‐Doping for Enhancing Oxygen Evolution Reaction
Authors: He Xuanmeng , Qiao Tong , Li Beijun , Zhang Zeqin , Wang Shaolan , Wang Xinzhen , Liu Hui 
Published: December 2022

AbstractCobalt‐based spinel oxide is a promising electrocatalyst for oxygen evolution reaction (OER) because of its low cost, excellent activity and stability. Herein, we designed the CuMnxCo2O4 electrocatalyst with tunable electronic structure via Mn‐doping to enhance OER performance. Results showed that the CuMn0.5Co2O4 catalyst prepared by calcined at 600°C exhibited high crystalline without impurity phase, and possessed the enhanced Co2+/Co3+ ratio and high concentration of oxygen vacancies, which were facilitated to enhance OER performance. Electrochemical test results showed the CuMn0.5Co2O4 catalyst had high OER performance with a low overpotential of 340 mV at the current density of 10 mA ⋅ cm−2 and a smaller Tafel slope of 69.8 mV ⋅ dec−1. TOF and ECSA results illustrated that the more intrinsic catalytic activity on the CuMn0.5Co2O4 catalyst. After 1000 cycles, the catalyst exhibited high stability with the 8 1.7 % of current retention rate. The OER activity enhancement mechanism of was further analyzed, which were mainly ascribed to the conversion of variable Co2+/Co3+ and enhanced oxygen vacancies.
Propanediol Cyclic Sulfate as An Electrolyte Additive to Improve the Cyclic Performance of LiNi0.6Co0.1Mn0.3O2/Graphite Pouch‐Cell at High Voltage
Authors: Liu Shuang , Qiu Wenjuan , Su Zhuoying , Li Jia , Xiao Xin , Nan Junmin , Zuo Xiaoxi 
Published: December 2022

AbstractBy using Ni‐rich material (LiNixCoyMnzO2, x+y+z=1) as cathode electrode, the energy density of lithium‐ion batteries can be increased. However, the electrode/electrolyte interface instability of Ni‐rich cathode at high voltage will adversely affect the cycle performance and limit its practical application. In this paper, propanediol cyclic sulfate (PCS) is proposed as a functional additive to improve the cycling stability of LiNi0.6Co0.1Mn0.3O2/graphite battery. After adding 3.0 wt.% PCS to the baseline electrolyte, the capacity retention of the batteries improves from 9.6 % to 86.5 % after 150 cycles at the voltages of 3.0–4.5 V. Based on the theoretical calculation and experimental result, the main reason for the improvement of electrochemical performance is that the PCS forms a highly stable sulfur‐containing compound interface layer (SEI/CEI) on the electrode surface, which can not only inhibit electrolyte decomposition and interface impedance increase, but also reduce transition metal dissolution. This work has given some ideas for the practical utilization of high‐voltage LiNi0.6Co0.1Mn0.3O2/graphite pouch‐cells.
Location‐specific target load level and object‐specific load models for recalculation based on structural monitoring
Authors: Steffens Nico , Geißler Karsten 
Published: December 2022

AbstractWhen evaluating existing bridges, supporting structural monitoring is increasingly being used in order to obtain the stresses in the structure more realistically than purely mathematically and to calibrate the calculation model. The question of how the additional information obtained through measurements have to be taken into account within the recalculation, including its safety concept, is currently still normatively unclear. On the load side, this can be done through the modified definition of the target load level or, alternatively, through object‐specific load models for load‐bearing capacity and fatigue to map the actual traffic. Furthermore, on the basis of the measurement data, the necessary safety factors can be justified, also taking into account future traffic developments, while maintaining the normatively required level of reliability.
Co‐Combustion of Oil Sludge Char and Brown Coal in a Continuous Fluidized‐Bed Combustor
Authors: Shi Bowen , Qiao Fa , Zhang Guangyi , Liu Xuan , Zhang Yuming , Wen Hongyan , Wang Fang , Zhang Jianling , Xu Guangwen 
Published: December 2022

AbstractFor developing technologies for innocent disposal of/energy recovery from high‐ash oil sludge char (OSC), it was continuously combusted in a 10 kg h−1 fluidized‐bed combustor. Addition of brown coal (BC) improved its combustion, but excessive BC was prone to cause slagging. Fine coke particles in OSC and volatiles in BC led to staged temperatures along the fluidized bed through air‐staging co‐combustion, enabling excellent combustion performance as well as efficient NOx reduction, especially when coupled with selective non‐catalytic reduction. Thus, there is a potential to cleanly recover energy from OSC by its co‐combustion with BC.
MAP3K1 rs889312 polymorphism and cancer prognosis: A systematic review and meta‐analysis
Authors: Aziz Md. Abdul , Islam Mohammad Safiqul 
Published: December 2022

AbstractBackgroundAccumulating studies have evaluated the association between MAP3K1 polymorphisms and cancer prognosis. However, the results of these studies are conflicting. Given the potential impact of MAP3K1 rs889312 SNP on the prognosis of various cancers, this meta‐analysis was performed to obtain solid and credible evidence.Methods and MaterialsThis study was performed according to the PRISMA 2020 statement. A comprehensive article search was conducted to find and select articles from multiple databases, including PubMed, Google Scholar, Web of Science, EMBASE and the Cochrane Library, published up to 15th September 2022. The data analysis was performed with Review Manager v5.2. Pooled HR with its 95% CI and p‐value was calculated where HR >1 suggests worse/poor survival and HR <1 suggests better survival of cancer patients.ResultsA total of five articles comprising 24 439 patients were included for both qualitative and quantitative data synthesis. It was found that only the dominant genetic model (AC + CC vs. AA) showed a statistically significant poor overall survival for MAP3K1 rs889312 polymorphism (HR = 1.25, 95% CI = 1.06–1.47, p = .01). In addition, publication bias analysis by the Egger's test and the Begg‐Mazumdar test reported no significant bias in the analysis of overall survival (p > .05).ConclusionsThe present study concludes that MAP3K1 gene rs889312 polymorphism plays a prognostic role in the survival of cancer patients. However, future research is recommended that will analyze more MAP3K SNPs along with rs889312, which may reveal more credible outcomes in terms of cancer prognosis.
Evaluation of Ethnicity Effect on Intranasal Esketamine Pharmacokinetics by Population Pharmacokinetic Modeling Using Data From a Japanese Phase 2b Study
Authors: Kurosawa Ken , Shibuya Minaka , Shimizu Hiroko , Pérez‐Ruixo Carlos 
Published: December 2022

AbstractEsketamine is used for the treatment of treatment‐resistant depression in many countries. A population pharmacokinetic (popPK) model of esketamine and its metabolite (noresketamine) has been previously developed, which included Asian race and Japanese ethnicity as covariates on their exposures. The present study aimed to update the popPK model by adding new data from a phase 2b study in Japanese patients and reassess intrinsic and extrinsic factors on esketamine and noresketamine exposures. The updated model identified the effects of body weight on the fraction of the esketamine dose absorbed in the nasal cavity and elimination rate constant of esketamine, and Asian race on the apparent clearance of noresketamine. The model predicted that an increase of 30 kg of body weight would decrease esketamine exposures by ≈20%. Noresketamine exposures would be affected by Asian race and body weight. However, those newly identified covariates were not considered to have clinically relevant impacts, and therefore dose adjustments were not necessary. In conclusion, the popPK model of esketamine and noresketamine was successfully updated and suggested that interindividual variability of esketamine exposures can be better explained by body weight, rather than by race/ethnicity. The new findings obtained in this study should be useful information for the further development of esketamine and for clinical practice in the future.
Synthesis and Characterization of a Cannabinoid Type 2 Receptor Photoactivated Prodrug
Authors: Yin Jiazhen , Sharma Raahul , Tyndall Joel D. A. , Grimsey Natasha L. , Vernall Andrea J. 
Published: December 2022

AbstractG protein‐coupled receptor (GPCR) ligand prodrugs that can be released on demand with spatiotemporal control are powerful chemical tools that can assist in elucidating the consequences of GPCR activation or blockade at precise locations and times both in vitro and in vivo. Cannabinoid receptor prodrugs are of interest from both a drug delivery perspective and as tools to unravel the potential for differential signaling responses to be produced from cannabinoid receptor populations in distinct subcellular locations. Herein, the development and characterization of a cannabinoid type 2 receptor agonist prodrug is described, based on a 4‐diethylamino‐coumarylidenemalononitrilemethyl (DEACM‐MN) photo caging moiety linked via a carbonate to a chromenopyrazole cannabinoid ligand. This prodrug showed rapid photolysis with 450–455 nm light and good stability in biologically relevant buffer. The formation of various coumarin products alongside drug release was studied in different conditions. Radioligand binding assays were conducted with the prodrug, which revealed a significantly decreased human cannabinoid type 2 receptor binding affinity than the active chromenopyrazole parent ligand.
Migration in drought: Receding streams contract the seaward migration window of endangered salmon
Authors: Kastl Brian , Obedzinski Mariska , Carlson Stephanie M. , Boucher William T. , Grantham Theodore E. 
Published: December 2022

AbstractProlonged migration windows buffer migratory animal populations against uncertainty in resource availability. Understanding how intensifying droughts from climate change influence the migration window is critical for biodiversity conservation in a warming world. We explored how drought affects the seaward migration of endangered coho salmon (Oncorhynchus kisutch) near the southern extent of their range in California, USA. We tracked stream departures of juvenile coho, measuring streamflow and temperature in seven streams over 13 years, spanning a historic drought with extreme dry and warm conditions. Linear mixed effects models indicate that, over the range of observations, a decrease in seasonal streamflow (from 4.5 to 0.5 mm/day seasonal runoff) contracted the migration window by 31% (from 11 to 7 weeks). An increase from 10.2 to 12.8°C in mean seasonal water temperature hastened the migration window by three weeks. Pacific salmon have evolved to synchronize ocean arrival with productive ocean upwelling. However, earlier and shorter migration windows during drought could lead to mismatches, decreasing fitness and population stability. Our study demonstrates that drought‐induced low flows and warming threaten coho salmon in California and suggests that environmental flow protections will be needed to support the seaward migration of Pacific salmon in a changing climate.