bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Incremental, Decremental or a Random Order of Loads does
not Affect Peak velocity Values during Bench Press Throw Load-velocity
Relationships
Authors: Sabido Rafael , Asencio Pablo , Garcia-Valverde Adrian , Garcia-Aguilar Fernando , Moreno-Lila Rodrigo , Davó Jose Luis Hernández 
Published: March 2023

AbstractThe aim of this study was to assess the influence of the load order used
(i. e. incremental, decremental or random loads order) during the bench
press throw load-velocity profile on peak velocity achieved against four
different loads (20–40–60–80% of one repetition
maximum [1RM]). Both intraclass correlation coefficient (ICC) and coefficient of
variation (CV) were calculated to assess the reliability of the measures. A
repeated measures ANOVA was used to assess differences between protocols. A
linear regression analysis was performed to assess the load-velocity
relationships among the different protocols. Peak velocity showed good to high
ICC values independently of the load used (ICC=0.83–0.92). CV
scores showed good reliability (ranging between 2.2 and 6.2%). No
significant differences in peak velocity attained at each load were found
between the three testing protocols (p>0.05). In addition, peak
velocity at each load was very large to almost perfect, correlated between
protocols (r=0.790–0.920). The linear regression model
showed a significant relationship between testing protocols
(p<0.001; R2=0.94). In conclusion, due to some
ICC scores below 0.9 and R2 below 0.95, the indistinct use of
different load-order protocols to assess load-velocity relationships in the
bench press throw exercise is not recommended.
Outcomes of Surgery for Benign Tumours in The Upper
Extremity
Authors: Zyluk Andrzej , Owczarska Ada 
Published: March 2023

AbstractBenign tumours of the upper extremity are common in hand surgeons’
practice. The most commonly diagnosed are giant-cell tumours of the tendon
sheath and lipomas.
The objective of this study was an investigation into the distribution of
tumours in the upper limb, their symptomatology and outcomes of surgery,
particularly regarding the rate of recurrence.
Material and Methods A total of 346 patients, 234 women (68%) and
112 men (32%), who had undergone surgery for tumours located in the
upper extremity which were not ganglion cysts were enrolled into the study. The
follow-up assessment was performed at a mean of 21 months (range 12–36)
post-operatively.
Results The most common tumour in this study was giant cell tumour of the
tendon sheath − 96 cases (27.7%), followed by lipoma −
44 cases (12.7%). Most lesions − 231 (67%) were
localized in the digits. A total of 79 (23%) recurrences were noted, the
most common after surgery for rheumatoid nodules - 43.3% and the
giant-cell tumours of the tendon sheath − 31.3%. The independent
factors increasing risk of recurrence following the tumour’s resection
were: histological type of the lesion - the giant-cell tumour of the tendon
sheath (p=0.0086) and the rheumatoid nodule (p=0.0027), as well
as a combination of incomplete (non-radical) and not “en block”
resection of tumours. A brief review of the literature referring to the
presented material is offered.
Synthesis of Cyclopropylamines through an Electro-Induced Hofmann Rearrangement
Authors: Charette André B. , Poisson Thomas , Jubault Philippe , Cantin Thomas 
Published: March 2023

AbstractA practical access to cyclopropylamines from the corresponding amides is disclosed, according to an electro-induced Hofmann rearrangement. In an undivided cell under galvanostatic conditions, a panel of cyclopropyl amides was readily converted into the corresponding amines (17 examples, 23% to 94% yield). This reaction allowed an easy access to the versatile cyclopropylamines and is complementary to the existing methods.
Preparation and Use of (γ,γ-Dioxyallyl)boronates
Authors: Hirano Koji , Nishino Soshi , Nishii Yuji 
Published: March 2023

AbstractA copper-catalyzed stereoselective 1,4-acylboration of α,β-unsaturated esters with B2pin2 and pivalic anhydride has been developed to afford the corresponding (E)-allylboronates with two distinct oxygenated functionalities at the γ positions, which are difficult to prepare by other means. The chemoselective post functionalizations of Bpin and pivalate moieties in the product are also demonstrated.
[1,3]-Dioxolo[4,5-f]benzodioxole (DBD) Fluorescent Dyes; Synthesis, Properties, and Applications
Authors: Wessig Pablo , Lehmann Max 
Published: March 2023

AbstractIn this review we give an overview of the syntheses and photophysical properties of the new class of fluorescent dyes based on a [1,3]-dioxolo[4,5-f]benzodioxole core and their derivatives. Starting from commercially available reactants (e.g., sesamol, 1,2,4,5-tetrachlorobenzene) the core units can be prepared in a simple manner. Then, the benzene core can be derivatized via lithiation and their photophysical properties can be adjusted as desired. The obtained fluorophores have an absorption range of 403–520 nm and an emission range of 495–665 nm. This class of fluorescent dyes is also characterized by a long fluorescence lifetime, a high stability towards photobleaching, large Stokes shifts, and small size. Thus, the DBD dyes are optimally suited for optical sensing.1	Introduction2	Synthesis3	Properties4	Applications
Light-dependent signal transduction in the marine diatom
Phaeodactylum tricornutum
Authors: Agarwal Ananya , Levitan Orly , Cruz de Carvalho Helena , Falkowski Paul G. 
Published: March 2023

Unlike most higher plants, unicellular algae can acclimate to changes in irradiance on time scales of hours to a few days. The process involves an enigmatic signaling pathway originating in the plastid that leads to coordinated changes in plastid and nuclear gene expression. To deepen our understanding of this process, we conducted functional studies to examine how the model diatom,
Phaeodactylum tricornutum,
acclimates to low light and sought to identify the molecules responsible for the phenomenon. We show that two transformants with altered expression of two putative signal transduction molecules, a light-specific soluble kinase and a plastid transmembrane protein, that appears to be regulated by a long noncoding natural antisense transcript, arising from the opposite strand, are physiologically incapable of photoacclimation. Based on these results, we propose a working model of the retrograde feedback in the signaling and regulation of photoacclimation in a marine diatom.
Persistent room-temperature valley polarization in graphite-filtered WS2 monolayer
Authors: Demeridou Ioanna , Mavrotsoupakis Emmanouil G , Mouchliadis Leonidas , Savvidis Pavlos G , Stratakis Emmanuel , Kioseoglou George 
Published: March 2023

Abstract
Transition metal dichalcogenide (TMD) monolayers (1L) in the 2H-phase are two-dimensional semiconductors with two valleys in their band structure that can be selectively populated using circularly polarized light. The choice of the substrate for monolayer TMDs is an essential factor for the optoelectronic properties and for achieving a high degree of valley polarization at room temperature (RT). In this work, we investigate the RT valley polarization of monolayer WS2 on different substrates. A degree of polarization of photoluminescence (PL) in excess of 27% is found from neutral excitons in 1L-WS2 on graphite at RT, under resonant excitation. Using chemical doping through photochlorination we modulate the polarization of the neutral exciton emission from 27% to 38% for 1L-WS2/graphite. We show that the valley polarization strongly depends on the interplay between doping and the choice of the supporting layer of TMDs. Time-resolved PL measurements, corroborated by a rate equation model accounting for the bright exciton population in the presence of a dark exciton reservoir support our findings. These results suggest a pathway towards engineering valley polarization and exciton lifetimes in TMDs, by controlling the carrier density and/or the dielectric environment at ambient conditions.
Sustainability assessment of virtual water flows through cereal and milled grain trade among US counties
Authors: Rathore Lokendra S , Aziz Danyal , Demeke Betelhem W , Mekonnen Mesfin M 
Published: March 2023

Abstract
Transference of the embedded water, so-called virtual water, in the trade of crops among regions within a country is often neglected, leading to no information about the impacts on the water resources of exporting regions, especially if those regions are water-stressed or, worse, water-scarce. Virtual water trade, if not considered through the lens of sustainability, could lead to adverse effects on the water resources of an exporting region. Previous related studies have quantified virtual water trade among the states in the United States providing valuable insights; however, information for specific crop trade among counties, its water footprint (WF) at the county scale, the resultant virtual water flow among counties, and the sustainability assessment of those virtual water flows are lacking. In this study, we calculate the green and blue WF of cereal and milled grain products at the county level and then, using trade data, calculate the virtual water flows among the counties. Then, we assess the sustainability of the import by introducing unsustainable import fraction (UIF), which is the ratio of virtual water imported from water-scarce counties to that of total virtual water imported in the form of cereal and milled grains. Finally, we quantify the change in UIF from the 2007–2017 period. A few of the significant insights discovered through this analysis include: (i) most of the cereal and milled grains trade is occurring among neighboring counties; ii) one-third of US counties import 75% or more virtual water from water scarce regions; (iii) in 2017, Texas and Missouri were the largest importer and exporter, respectively; and (iv) the number of counties importing cereals and milled grains from water-scarce counties increased from 2007 to 2017. Recommendations on alleviating the negative effects of the unsustainable import of cereal and milled grain are provided toward the end of the discussion.
Management and Follow-up of Massive Fetomaternal Hemorrhage Requiring High-Dose Rh Immune Globulin: A Case Report
Authors: Fortes Precious Ann , Gnass Esteban D , Baez Janet , Bayati Banafsheh , Mei Zhen , McGonigle Andrea M , Ziman Alyssa , Ward Dawn C 
Published: March 2023

Abstract

Objectives
Massive fetomaternal hemorrhage (FMH) is rare and reported to be the cause in approximately 3% of all fetal deaths. Maternal management of massive FMH includes prevention of Rh(D) alloimmunization in Rh(D)-negative mothers by administration of Rh(D) immune globulin (RhIG).

Methods
We describe a case of a 30-year-old O-negative, primigravida woman who presented at 38 weeks of gestation with decreased fetal movements. She underwent an emergency cesarean section and delivered an O-positive baby girl who died shortly after birth.

Results
The patient’s FMH screen was positive, with a Kleihauer-Betke test demonstrating 10.7% fetal blood in maternal circulation. The calculated dose of 6,300 µg RhIG was given prior to discharge over 2 days using an intravenous (IV) preparation. Antibody screening a week after discharge showed anti-D and anti-C. The anti-C was attributed to acquired passive immunity from the large dose of RhIG. Anti-C reactivity waned and was negative at 6 months, but the anti-D pattern persisted at 9 months postdelivery. Negative antibody screens were noted at 12 and 14 months.

Conclusions
This case highlights the immunohematology challenges of IV RhIG as well as the success in preventing alloimmunization with IV RhIG given the patient’s complete resolution of anti-C and no anti-D formation, with a subsequent healthy pregnancy.
Wind-farm and hydrogen-storage co-location system optimization for dynamic frequency response in the UK
Authors: Fan Fulin , Skellern Shanay , Campos-Gaona David , Nwobu John 
Published: March 2023

AbstractThe continuous development of hydrogen-electrolyser and fuel-cell technologies not only reduces their investment and operating costs but also improves their technical performance to meet fast-acting requirements of electrical grid balancing services such as frequency-response services. In order to project the feasibility of co-locating a hydrogen-storage system with a wind farm for the dynamic regulation frequency-response provision in Great Britain, this paper develops a modelling framework to coordinate the wind export and frequency responses to the main grid and manage the interaction of the electrolyser, compressor, storage tank and fuel cell within the hydrogen-storage system by respecting the market mechanisms and the balance and conversion of power and hydrogen flows. Then the revenue of frequency-response service provision and a variety of costs induced by the hydrogen-storage system are translated into the net profit of the co-location system, which is maximized by optimizing the capacities of hydrogen-storage-system components, hydrogen-storage levels that guide the hydrogen restoration via operational baselines and the power interchange between a wind-farm and hydrogen-storage system, as well as the capacities tendered for low- and high-frequency dynamic regulation services. The developed modelling framework is tested based on a particular 432-MW offshore wind farm in Great Britain combined with the techno-economics of electrolysers and fuel cells projected for 2030 and 2050 scenarios. The optimized system configuration and operation are compared between different operating scenarios and discussed alongside the prospect of applying hydrogen-storage systems for frequency-response provision.
Ozone pollution and hospital admissions for cardiovascular events
Authors: Jiang Yunxing , Huang Jing , Li Guoxing , Wang Wanzhou , Wang Kai , Wang Jinxi , Wei Chen , Li Yinxiang , Deng Furong , Baccarelli Andrea A , Guo Xinbiao , Wu Shaowei 
Published: March 2023

Abstract

Aims
The available literature on morbidity risk of cardiovascular diseases associated with ambient ozone pollution is still limited. This study examined the potential acute effects of exposure to ambient ozone pollution on hospital admissions of cardiovascular events in China.

Methods and results
A two-stage multi-city time-series study approach was used to explore the associations of exposure to ambient ozone with daily hospital admissions (n = 6 444 441) for cardiovascular events in 70 Chinese cities of prefecture-level or above during 2015–17. A 10 μg/m3 increment in 2-day average daily 8 h maximum ozone concentrations was associated with admission risk increases of 0.46% [95% confidence interval (CI): 0.28%, 0.64%] in coronary heart disease, 0.45% (95% CI: 0.13%, 0.77%) in angina pectoris, 0.75% (95% CI: 0.38%, 1.13%) in acute myocardial infarction (AMI), 0.70% (95% CI: 0.41%, 1.00%) in acute coronary syndrome, 0.50% (95% CI: 0.24%, 0.77%) in heart failure, 0.40% (95% CI: 0.23%, 0.58%) in stroke and 0.41% (95% CI: 0.22%, 0.60%) in ischemic stroke, respectively. The excess admission risks for these cardiovascular events associated with high ozone pollution days (with 2-day average 8-h maximum concentrations ≥100 µg/m3 vs. &lt; 70 µg/m3) ranged from 3.38% (95% CI: 1.73%, 5.06%) for stroke to 6.52% (95% CI: 2.92%, 10.24%) for AMI.

Conclusion
Ambient ozone was associated with increased hospital admission risk for cardiovascular events. Greater admission risks for cardiovascular events were observed under high ozone pollution days. These results provide evidence for the harmful cardiovascular effects of ambient ozone and call for special attention on the control of high ozone pollution.
Efficacy of ceftazidime/avibactam in various combinations for the treatment of experimental osteomyelitis in rabbits caused by OXA-48-/ESBL-producing Escherichia coli
Authors: Davido Benjamin , Crémieux Anne-Claude , Vaugier Isabelle , De Truchis Pierre , Hamami Kamel , Laurent Frédéric , Saleh-Mghir Azzam 
Published: March 2023

Abstract

Background
While the treatment of ESBL-producing Enterobacterales osteomyelitis relies on carbapenems, the optimal regimen for OXA48 types remains unclear. We evaluated the efficacy of ceftazidime/avibactam in different combinations in an experimental model of OXA-48-/ESBL-producing Escherichia coli osteomyelitis.

Methods
E. coli pACYC184 is a clinical strain harbouring blaOXA-48 and blaCTX-M-15 inserts, with ‘increased exposure susceptibility’ to imipenem (MIC, 2 mg/L), gentamicin (MIC, 0.5 mg/L), colistin (MIC, 0.25 mg/L), ceftazidime/avibactam (MIC, 0.094 mg/L) and fosfomycin (MIC, 1 mg/L), and resistance to ceftazidime (MIC, 16 mg/L). Osteomyelitis was induced in rabbits by tibial injection of 2 × 108 cfu of OXA-48/ESBL E. coli. Treatment started 14 days later for 7 days in six groups: (1) control, (2) colistin 150.000 IU/kg subcutaneously (SC) q8h, (3) ceftazidime/avibactam 100/25 mg/kg SC q8h, (4) ceftazidime/avibactam + colistin, (5) ceftazidime/avibactam + fosfomycin 150 mg/kg SC q12h, (6) ceftazidime/avibactam + gentamicin 15 mg/kg intramuscularly (IM) q24h. Treatment was evaluated at Day 24 according to bone cultures.

Results
In vitro, time–kill curves of ceftazidime/avibactam in combination showed a synergistic effect. In vivo, compared with controls, rabbits treated with colistin alone had similar bone bacterial density (P = 0.50), whereas ceftazidime/avibactam alone or in combinations significantly decreased bone bacterial densities (P = 0.004 and P &lt; 0.0002, respectively). Bone sterilization was achieved using ceftazidime/avibactam in combination with colistin (91%) or fosfomycin (100%) or gentamicin (100%) (P &lt; 0.0001), whereas single therapies were not different from controls. No ceftazidime/avibactam-resistant strains emerged in rabbits treated, regardless of the combination.

Conclusions
In our model of E. coli OXA-48/ESBL osteomyelitis, ceftazidime/avibactam in combination was more effective than any single therapy, whatever the companion drug used (gentamicin or colistin or fosfomycin).
Stellar prospects for FRB gravitational lensing
Authors: Connor Liam , Ravi Vikram 
Published: March 2023

ABSTRACTGravitational lensing of fast radio bursts (FRBs) offers an exciting avenue for several cosmological applications. However, it is not yet clear how many such events future surveys will detect nor how to optimally find them. We use the known properties of FRBs to forecast detection rates of gravitational lensing on delay time-scales from microseconds to years, corresponding to lens masses spanning 15 orders of magnitude. We highlight the role of the FRB redshift distribution on our ability to observe gravitational lensing. We consider cosmological lensing of FRBs by stars in foreground galaxies and show that strong stellar lensing will dominate on microsecond time-scales. Upcoming surveys such as DSA-2000 and CHORD will constrain the fraction of dark matter in compact objects (e.g. primordial black holes) and may detect millilensing events from intermediate mass black holes (IMBHs) or small dark matter halos. Coherent all-sky monitors will be able to detect longer-duration lensing events from massive galaxies, in addition to short time-scale lensing. Finally, we propose a new application of FRB gravitational lensing that will measure directly the circumgalactic medium of intervening galaxies.
Priorities in gravitational waveforms for future space-borne detectors: vacuum accuracy or environment?
Authors: Zwick Lorenz , Capelo Pedro R , Mayer Lucio 
Published: March 2023

ABSTRACT
In preparation for future space-borne gravitational-wave (GW) detectors, should the modelling effort focus on high-precision vacuum templates or on the astrophysical environment of the sources? We perform a systematic comparison of the phase contributions caused by (1) known environmental effects in both gaseous and stellar matter backgrounds, or (2) high-order post-Newtonian (PN) terms in the evolution of mHz GW sources during the inspiral stage of massive binaries. We use the accuracy of currently available analytical waveform models as a benchmark value, finding the following trends: the largest unmodelled phase contributions are likely environmental rather than PN for binaries lighter than ∼107/(1 + z)2 M⊙, where z is the redshift. Binaries heavier than ∼108/(1 + z) M⊙ do not require more accurate inspiral waveforms due to low signal-to-noise ratios (SNRs). For high-SNR sources, environmental phase contributions are relevant at low redshift, while high-order vacuum templates are required at z ≳ 4. Led by these findings, we argue that including environmental effects in waveform models should be prioritized in order to maximize the science yield of future mHz detectors.
Intraocular Pressure Spikes Following iStent Inject and the Relationship to Aqueous Outflow in Open Angle Glaucoma
Authors: Lusthaus Jed A. , McCluskey Peter J. , Martin Keith R. 
Published: March 2023

Précis:Adding trabecular bypass surgery (TBS) to phacoemulsification creates unpredictable short-term intraocular pressure (IOP) control that may be undesirable for patients with advanced glaucoma. Aqueous outflow (AO) responses after TBS are complex and probably multifactorial.Purpose:To assess IOP spikes in patients with open angle glaucoma up to 1 month after iStent inject and their relationship to AO patterns measured by hemoglobin video imaging (HVI).Participants and Methods:We studied IOP for 4 weeks after TBS with iStent inject in 105 consecutive eyes with open angle glaucoma (6 TBS only and 99 combined with phacoemulsification). The change in IOP after surgery at each time point was compared with baseline measurements and the prior postoperative visit. IOP-lowering medications were stopped on the day of surgery in all patients. A smaller pilot study of 20 eyes (TBS only = 6 and combined = 14) underwent concurrent HVI to observe and quantify perioperative AO. Aqueous column cross-sectional area (AqCA) of one nasal and one temporal aqueous vein was calculated at each time point, and qualitative observations were documented. An additional 5 eyes were studied after phacoemulsification only.Results:Mean IOP for the entire cohort (preoperative 17.3 ± 5.6 mm Hg) was lowest the day after TBS (13.1 ± 5.0 mm Hg) and peaked at 1 week (17.2 ± 8.0 mm Hg), before stabilizing by 4 weeks (15.2 ± 5.2 mm Hg;P< 0.00001). The same IOP pattern was seen when separating the group into a larger cohort without HVI (respectively 15.9 ± 3.2 mm Hg, 12.8 ± 4.9 mm Hg, 16.4 ± 7.4 mm Hg, and 14.1 ± 4.1 mm Hg; N = 85,P< 0.00001) and the smaller HVI pilot study (respectively 21.4 ± 9.9 mm Hg, 14.2 ± 4.9 mm Hg, 20.2 ± 9.7 mm Hg, and 18.9 ± 7.6 mm Hg; N = 20,P< 0.001). More than 30% IOP elevation above baseline occurred in 13.3% of the entire cohort at 1 week after surgery. This increased to 46.7% when IOP was compared with 1 day after surgery. Inconsistent AqCA values and patterns of aqueous flow were demonstrated after TBS. AqCA after phacoemulsification alone was maintained or increased within 1 week in all 5 eyes.Conclusion:After iStent inject surgery in patients with open angle glaucoma, intraocular spikes were most commonly seen at 1 week. AO patterns were variable and additional studies are needed to understand the pathophysiology underlying IOP responses after this procedure.