bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tympanoplasty in Pediatric Age Group: Meta Analysis Study
Authors: Baghdady Zainab Ashraf , Ibrahim Samer Ahmed , Abdelrazek Amr Nabil , Teaima Ahmed Abdelmoneim 
Published: August 2023

Abstract

Objectives
To evaluate the success rate and audiological results of pediatric tympanoplasty

Methods
Metanalysis study of articles involving of pediatric patients who underwent myringoplasty between the years 1995 to 2019, in Medline, Cochrane database. Anatomical and functional success were evaluated also ABG improvement. The influence of age on tympanic membrane closure were examined, publication bias was assessed and pooling of estimates were expressed. Our study consisted of 31 studies done on 2546 patients, with a mean age 10 years, DerSimonian-laird random effects and Forest plots were used for analysis.

Results
The anatomical success and the functional were 87% and 77% respectively. With the increase of age by 1 year the increase in functional success and anatomical success was 1% and 0.1% respectively also the ABG improvement around 0.2648 db.

Conclusion
Pediatric myringoplasty is associated with high rate of success, with a high rate of hearing improvement. Age under 7 is associated with less success.
Body Mass Index and Nutritional Intake among Primary School Children in Urban Area, Egypt
Authors: Mohamed Maha Hassan , Razek Suzan Abd El , Gabal Hebat Allah M S , Salama Maha Mohsen 
Published: August 2023

Abstract

Introduction
Primary school children are more vulnerable to malnutrition; underweight or obesity. Continuous nutritional assessment of the vulnerable groups is very important for the evaluation of current health status, besides future planning for prevention and control programs.

Aim of the Work
To assess the nutritional status and body mass index among primary school children attending primary healthcare centre in 10th of Ramadan city, El Sharqia Governorate, Egypt, and to identify different demographic factors that can affect nutritional status among them.

Materials and Methods
A cross-sectional study was conducted among 60 randomly selected primary school children. An interview questionnaire was used to collect data including demographic characteristics, family history of obesity, food intake using food frequency formula and the pyramid of food servings. Anthropometric characteristics including weight, height and BMI was estimated.

Results
The age ranged (6-12) for males and (6-9) for females, the mean was 8.62 and SD was 1.69. The mean height and weight of studied children were 127.33 ± 11.20 cm and 36.23 ± 13.74 kg respectively. Most of them had normal current weight (41.7%) and normal birth weight (86.7%). Overweight and obese represent 8.3% and 16.7% respectively, while underweighted children represent 33.3%. BMI was associated with child age, family opinion in child weight, birth weight and family history of obesity. Most of studied children took sufficient amount of animal protein, while consuming grains & carbohydrates, beans, vegetables, fruits and fats 4-6 times per week. 80.0% consume sweets & processed sugar 4-6 times per week. Consumption of junk foods and soft drinks and juices was high (66.7% for each) 4-6 times per week. Diet was statistically associated with BMI (frequency and standard requirements); overweight and obese children took carbohydrates & grains, soft drinks &juices and junk foods in amounts that above the standard requirements and in higher frequency compared to underweight and normal weight children (≥4 times per week). The consumption of vegetables and fruits was not related to BMI as most of participated children took them at the standard requirement.

Conclusion and recommendations
The prevalence of malnutrition disorder (underweight and obesity) among primary school children in 10th of Ramadan City is considerable. High BMI was associated with high frequency of eating carbohydrates& grains, soft drinks & juices, fats and junk foods and their daily requirements. Low BMI in underweight children not related to significant type of food as they mainly took their standard requirements in frequency around 4 times per week. Feasible and effective nutritional and educational programs for primary school children must consider child characteristics and eating habits.
Evaluation of Round Block Oncoplastic Breast Surgery in Early Juxta-Areolar Breast Cancer in Comparison to Standard Wide Local Excision (Retrospective Study)
Authors: Helmy Mohamed Ahmed , Rayyan Mahmoud Talaat , El-trras Hasan Reda 
Published: August 2023

Abstract

Background
Breast cancer is the most common cancer in women and the leading cause of women mortality all over the world. Oncoplastic techniques are replacing SWLE for better cosmetic outcomes and better exposure of the tumor.

Objective
To assess the round block technique as regard oncological safety, surgical outcomes and patients' satisfaction comparing results with standard wide local excision.

Patients and Methods
In our study 40 breast cancer patients are subdivided into group (A) 20 females which underwent round block technique and group (B) 20 femaleswhich underwent standard wide local excision. Patient and tumor criteria including age, family history, comorbidities, tumor side and histopathological results were considered to be non-significant between 2 groups so the only difference is the surgical technique.

Results
The study shows that round block technique has comparable post-operative parameters with less surgical complications and better cosmoses as it is scarless operation without nipple and areola shift suggesting that the round block technique is superior to SWLE in selected cases.

Conclusion
The round block technique has comparable post-operative parameters with less surgical complications and better cosmoses as it is scarless operation without nipple and areola shift suggesting that the round block technique is superior to SWLE in selected cases.
The Effect of Adding Pyloroplasty to Nissen Fundoplication in Improving the Outcome in Patients with Delayed Gastric Emptying Associating Gastro Esophageal Reflux Disease: A Meta-Analysis
Authors: Ezz Reda Saad Mohammad , El-Hefny Amr Mohamed Mahmoud , Hamed Mohammad Abdel Mageed Alsaid , Moneam Ayman Hossam Eldin Abdel , Sonbol Hoda Ali Ahmad 
Published: August 2023

Abstract

Background
An important consideration for patients with GERD is the possibility of underlying gastroparesis defined as delayed gastric emptying in the absence of mechanical obstruction. The addition of a pyloroplasty to nissen fundoplication in patients with GERD is said to improve bloating symptoms and promote faster gastric emptying.

Aim of the Work
The aim of this meta-analysis study is to identify the effect of adding pyloroplasty to Nissen Fundoplication in improving the outcome in patients with delayed gastric emptying associating Gastro esophageal reflux disease.

Patients and Methods
Types of studies used Published studies about the effect of adding pyloroplasty to Nissen Fundoplication in improving the outcome in patients with delayed gastric emptying associating Gastro esophageal reflux disease (carried out in the period between 2000 – 2020). The published English-language literature was searched in the databases PUBMED (US National Library of Medicine, Bethesda, Maryland) (2000 to present), EMBASE (Reed Elsevier PLC, Amsterdam, Netherlands) (2000 to present), as well as Google Scholar and Science direct.
The search terms was employed: “Pyloroplasty” and “Delayed gastric emptying” or “gastroparesis” and “Nissen’s fundoplication”.

Results
A total of four studies reported there was statistically significant decrease in the T1/2 postoperative (90.62 ± 15.64) than preoperative (192.42 ± 28.10) with p-value &lt;0.001. The change from pre to postoperative t ½ with a total sample size of 164 patients. The overall effect estimates noted a significant reduction in the t ½ by 116.5 (95% CI 85.9 – 146.9) minutes. The pooled effect estimates showed significant heterogeneity (p = 0.016; I2 =71%). A total of four studies reported the rate of symptomatic improvement with a total sample size of 164 patients. The overall effect estimates noted a symptomatic improvement rate by 84% (95% CI 78.6 – 89.7%). The pooled effect estimates showed no significant heterogeneity (p = 0.66; I2 =0%).

Conclusion
Laparoscopic pyloroplasty with Nissen’s fundoplication is an effective procedure and might be considered as a first-line treatment for selected cases of gastroparesis. We report an 84% symptomatic improvement rate and 71% improvement rate for gastric emptying times measured by scintigraphy. The procedure can be performed with a minimally invasive technique with low morbidity and no mortality. The laparoscopic approach does not preclude subsequent procedures when required.
Role of Mesh in the Reinforcement of the Primary Repair of Large Hiatal Hernia
Authors: Gad Khalid Hussien , El Hefny Amr Mohamed M , Al Sayed Mohammed Abd Almegeed , Eldin Ayman Hossam , Elkaialy Hossam Abdelrahman Abdelrahman Yassin 
Published: August 2023

Abstract

Background
The incidence of hiatal hernias increases with age. Approximately 55%-60% of individuals over the age of 50 have a hiatal hernia. However, only about 9% have symptoms, and it depends on the type and competency of the lower esophageal sphincter.

Aim of the Work
In our study, an objective observational study was made regarding post operative short term mesh related complications possible to develop in patients underwent hiatal repair of large hiatal hernia with mesh rienforcement.

Patients and Methods
An observational cohort (retrospective and prospective) study regarding the post operative mesh related complications in patients who underwent Large diaphragmatic hernia repair with mesh application. The study was conducted at Ain Shams University Hospitals, Al-Demerdash, Department of General surgery. Approval of the research ethics Committee of medicine and general surgery department at faculty of medicine, Ain Shams University as well as a written informed consent from all participants was obtained. The study was conducted on 15 patients over a period of six months, starting from date of approval of the protocol by the faculty and the university committee at 10/7/2021.

Results
Five patients (33.3%) complained about dysphagia postoperatively. In one case, the symptoms declined spontaneously within 6 months was grade 1. Another patient successfully underwent esophageal dilatation of a stenosis 2 months postoperatively was grade 2. Up to this date, two patients (13.3%) still report mild dysphagia but maintain normal body weight were grade 3. Three cases report persistent intraabdominal discomfort without weight loss described as bloating. Two patients experienced heartburn, while another patient reported respiratory compromise in the form dyspnea due to already huge hiatal defect with lung collapse present preoperatively.

Conclusion
Laparoscopic large hiatal/paraesophageal hernia repair with prosthetic meshes as well as laparoscopic antireflux surgery with prosthetic hiatal closure are safe and effective procedures to prevent hiatal hernia recurrence and/or postoperative intrathoracic wrap migration, with low complication rates and mesh fixation is indicated in patients with large hiatal hernial defect &gt; 5 cm.
Meta-Analysis of Predictors of Post-Thyroidectomy Hypocalcaemia
Authors: El-kharadly Mahmoud , Saad Mahmoud , Al-maleh Haitham , Fadl Ehab Mohammed Ali 
Published: August 2023

Abstract

Background
Hypocalcaemia is common after thyroidectomy. Accurate prediction and appropriate management may help reduce morbidity and hospital stay. The aim of this study was to perform a systematic literature review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia.

Patients and Methods
A systematic search of PubMed and the Cochrane Library databases was undertaken, and the evaluation of titles, abstracts, eligibility and quality of studies.

Results
11 articles were included. Clinical predictors that had a significant association with post thyroidectomy hypocalcemia include female patients [OR = 0.625, 95% CI (0.420–0.932), p-value = 0.021], patients who did autotransplantation [OR = 2.020, 95% CI (0.968–4.215), p-value = 0.061] and patients who did cervical LN dissection [OR = 1.680, 95% CI (1.054–2.679), p-value = 0.029]. Clinical predictors that had higher insignificant association with post thyroidectomy hypocalcemia include patients with Graves' disease [Odds ratio (OR) = 1.054, 95% CI (0.623–1.784), p-value = 0.844], patients with more than two parathyroid glands preserved [OR = 1.131, 95% CI (0.259–4.939), p-value = 0.870] and patients who did not undergo reoperation [OR = 0.963, 95% CI (0.594–1.563), p-value=0.879].

Conclusion
Clinical predictors of post Thyroidectomy hypocalcaemia include female sex, autotransplantation and cervical LN dissection.
A Modified Surgical Technique in Biliary Reconstruction in Living Donor Liver Transplantation and Its Impact on Postoperative Incidence of Biliary Leakage and Stricture
Authors: Abdelghaffar Mohammed F , Abd El wahab Sameh , Elghandoor Abdelrahman M , Mohammed Motafa Abdelrahman , Gouda Mohammed Hisham , Atalla Martina 
Published: August 2023

Abstract

Background
Biliary complications continue to be a challenging territory in living donor liver transplantation that could lead eventually to graft loss and increased mortality. Despite the continuous evolution of biliary reconstruction techniques, there is no single full proof method that could possibly ensure the best biliary reconstruction.

Aim of work
In this study we compare the results of our combined modified technique of biliary reconstruction to the results of the conventional techniques in terms of improving biliary complications particularly biliary leaks and strictures.

Methods
This study was conducted on two equal groups of patients (recipients), 52 each, one of them received the conventional technique and the other received the modified technique.

Results
Our results have shown that the modified technique dropped the biliary complications from 36.5 to 9.6%, bile leaks dropped from 9.6% to 3.8%, and strictures dropped from 30.8% to 7.7%.

Conclusion
HPGS approach in the donor surgery together with en bloc hilar dissection and the eversion technique in the recipient surgery improve postoperative biliary complications.
Comparative Study between Total Thyroidectomy with Ipsilateral versus Bilateral Prophylactic Central Neck Dissection in Patients with Clinically Node – Negative Papillary Thyroid Carcinoma. A Meta-Analysis
Authors: El-Shafaei Mahmoud Ahmed Mohamed , Abd elmageed Shaaban Mohamed Mohamed , Omran Hesham Mohamed Ali , Academic Mohamed Hesham Saeed Hassan Gouda , Hassan Mohamed Hassan Mohamed 
Published: August 2023

Abstract

Background
Papillary thyroid carcinoma (PTC) accounts for &gt; 80% of all thyroid malignancies. It is generally slow-growing and the overall prognosis is excellent, with 5-year, 10-year, and 20-year survival rates of 94%, 89%, and 87%, respectively.

Aim of the Work
The aim of this study is to compare between unilateral PCND and bilateral PCND in patients with clinically unifocal cN0 PTC using meta-analysis approach

Methodology
A Systemic review and meta-analysis Study was performed after the data extraction process. Five studies comparing the out-comes of unilateral PCND and bilateral PCND procedures in adult patients with PTC CN0 were included in this study. The publicly available literature on PubMed, and, the Web of Knowledge, and the China Journal Net, EMBASE, Cochrane Library, and Scopus databases and the ClinicalTrials.gov registry. Published from January 2005 to December 2020 concerning TT plus ipsilateral PCND versus TT plus bilateral PCND for PTC CN0 will be retrieved by searching the national and international online databases.

Results
The result of our study revealed that: Bilateral central neck dissection had higher insignificant operative time than ipsilateral one, bilateral central neck dissection had higher overall significant complications rate than ipsilateral one, bilateral central neck dissection had higher significant permanent hypo PTH and insignificant hematoma, seroma, and transient hypo PTH rate than ipsilateral one, ipsilateral central neck dissection had higher insignificant PRLNP, TRLNP rate nearly equal with bilateral one, ipsilateral CND appears to be sufficient in patients with tumors&lt;1 cm as bilateral central neck dissection had higher insignificant tumor size than ipsilateral one, there was no statistically significant difference found between unilateral PCND and bilateral PCND regarding rate of recurrence.

Conclusion
We suggest that, ipsilateral central neck dissection may be a reasonable surgical option for prophylactic CND in unilateral PTC with clinically negative lymph nodes because of its lower rates of contralateral paratracheal node metastasis and transient hypoparathyroidism and lower complications than bilateral pCND. and effective for selected patients undergoing a total thyroidecto- my for cN0 unilateral PTC.
Incidental Parathyroidectomy during Thyroidectomy: Risk Factors and Outcomes: A Systematic Review and Meta-Analysis
Authors: Ahmed Osama Mahmoud Elsayed , Nageeb Ramy Mikhael , Goda Mohamed Hesham , Shalaby Mohamed Kadry Abdelsamea 
Published: August 2023

Abstract

Background
Thyroidectomy is a widely used and relatively safe procedure having a major postoperative morbidity of less than 5% for experienced surgeons. Major complications include recurrent laryngeal nerve injury, postoperative hemorrhage and hypocalcemia.

Aim of the Work
It aims to perform a systematic review and meta-analysis of studies and reports to identify the risk factors of IP and the effect of IP on postoperative hypocalcemia during thyroidectomy.

Patients and Methods
We followed the PRISMA statement guidelines during this systematic review and meta-analysis preparation and performed all steps according to the Cochrane handbook of systematic reviews of intervention. We searched PubMed, Scopus, Cochrane, and Web of Science, Embase, and Science Direct from 2000 till September 2021 relevant keywords. We used the following search strategy for searching different databases: (“incidental parathyroidectomy” OR “unintentional parathyroidectomy” OR “inadvertent parathyroidectomy”, “thyroidectomy” OR “thyroid surgery” OR “thyroid resection” OR “incidental parathyroidectomy” OR “unintentional parathyroidectomy” OR “inadvertent parathyroidectomy”, “thyroidectomy” OR “thyroid surgery” OR “thyroid resection”) AND (“hypocalcemia” OR “low calcium level” OR “hypocalcemia” OR “hypoparathyroidism”). All the references of the included studies were searched for relevant studies.

Results
Even in the hands of experienced surgeons, incidental parathyroidectomy can occur during any thyroid operation. The incidence of IP in thyroidectomy ranged from 2.9 percent to 51.1 percent, according to the articles included in our review. Postoperatively, 2.2–50.0 percent of incidentally excised parathyroid glands were identified as intrathyroidal, indicating that complete IP elimination is nearly impossible. However, because 16.7–40.0 percent of incidentally excised parathyroid glands were found in an intracapsular location and 15.7–81.1 percent were found in an extracapsular location, more diligent intraoperative identification of the parathyroid gland may reduce the incidence of IP. We found that malignancy, total thyroidectomy, central neck dissection and reoperation are significant risk factors of incidental parathyriodectomy. IP was found to increase the incidence of temporary/ permanent and permanent postoperative hypocalcemia

Conclusion
Malignancy, total thyroidectomy, central neck dissection, and reoperation are all significant risk factors for IP, according to this meta-analysis. IP was found to increase the incidence of temporary/ permanent and permanent postoperative hypocalcemia.
Histological Study on the Potential Role of Exosomes Released from Mesenchymal Stem Cells on Healing of Cutaneous Wound in Adult Male Albino Rats
Authors: Ahmed Asmaa Ali Mohamed , Hafez Manal Shaaban , Hamam Ghada Galal , Ibrahim Gehan Abd ElKhalek 
Published: August 2023

Abstract

Introduction
Skin wounds are frequent injuries that cause heavy financial burdens at both the familial and societal levels with physical and mental suffering. Recently, the attention of researchers has been attracted to the use of exosomes derived from mesenchymal stem cells (MSCs) as a novel non-cell therapy.

Aim
To study the potential effects of exosomes derived from MSCs on the healing of cutaneous skin wound in adult male albino rats.

Materials and methods
47 adult male albino rats were used in this study. They were divided into three groups: group I (control group), group II (cutaneous wound group, that were left for spontaneous healing), and group III (cutaneous wound treated with intravenous injection of exosomes). Each group was subdivided into subgroup a (lasted for two weeks) and subgroup b (lasted for three weeks). A full thickness skin wound was generated through surgery on the back of rats in groups II and III. Exosomes were isolated from bone marrow derived-MSCs through ultracentrifugation. Then, they were characterized by transmission electron microscope. At the end of experiment, skin specimens were collected from all rats and were subjected to proper histological techniques.

Results
This study showed that MSCs-derived exosomes have significantly improved wound healing, accelerated wound closure, promoted the reepithelialization and the recovery of skin appendages as well as enhancing the organization of newly formed collagen fibers.

Conclusion
Intravenous injection of MSCs-derived exosomes is effective in healing of full thickness skin wound.
A Comparative Histological Study on the Role of Umbilical Cord Mesenchymal Stem Cells versus Their Conditioned Medium on the Pancreatic Beta Cells in Experimentally Induced Diabetes Mellitus in Albino Rat
Authors: Kader Nermeen Hamed Abd El , Zeid Asmaa Abd ElMonem Abo , Raafat Mona Hussien , Mekawy Mohamed Abd El-Rahman 
Published: August 2023

Abstract

Background
Mesenchymal stem cells (MSCs) represent a promising population for supporting new clinical concepts in cellular therapy. Umbilical cord blood (UCB) has turned out to be an excellent alternative source of MSCs. This study had compared the role of human umbilical cord blood derived mesenchymal stem cells (UCB-MSCs) versus their conditioned medium (CM) alone on pancreatic beta cells in a rat model of Streptozotocin (STZ)-induced type I diabetes Mellitus.

Material and Methods
Forty adult male albino rats were divided randomly into 4 groups; Group I (control), Group II (STZ), rats received a single dose of intraperitoneal injection of 35 mg/kg of STZ dissolved in 1 ml sodium citrate buffer. Group III (STZ + UCB-MSCs) after rats had been confirmed to be diabetic they received single dose of 1 × 106 cells /ml of UCB-MSCs into tail vein, meanwhile Group IV (STZ+ CM) rats received 0.5 ml of CM that was injected intramuscularly once per week for 4 weeks. After 4 weeks the Pancreas from all groups were dissected and stained by Hematoxylin & eosin stain and by immunohistochemical method using anti-insulin antibody to detect insulin granules in the Beta cells of the islets. Mean area percent of insulin positive reactions were measured and statistically analyzed.

Results
H&E-stained section of group II (STZ) showed the nuclei of the islet cells small condensed and darkly stained while, the blood capillaries were congested in endocrine pancreas.Meanwhile, Group III (STZ + UCB-MSCs) restored nearly normal histological features. Sections of Group IV (STZ+CM) showed few cells of the islets sections of showed vacuolations and small darkly stained condensed nuclei. Studying the groups immunohistochemically, revealed decrease in insulin positive reactions in Group II (STZ) while an increase in insulin positive reactions noticed in group III (STZ +UCB-MSC) and group IV (STZ+CM) when compared to group II (STZ) with more increase in group III (STZ+UCB-MSC) than group IV (STZ+CM).

Conclusion
It can be considered that intravenous UCB-MSCs could be more effective than CM in treatment of STZ-induced type I diabetes in the pancreas.