bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study on garbage code redistribution methods for heart failure at city level by two approaches
Authors: Liu Liqun , Cai Zemin , Wang Xuewei , Wang Chunping , Ma Xiangyun , Meng Xianfeng , Ning Bofu , Li Ning , Wan Xia 
Published: August 2023

Abstract
Background
Garbage code (GC) in death surveillance data may affect the statistics on causes of death. The Global Burden of Disease (GBD) studies have proposed several methods to redistribute GCs to the plausible correct underlying cause of death (UCOD). Take heart failure as an example, this study aimed to explore suitable GC redistribution methods at the city level.
Methods
The cause of death surveillance data was from Weifang city, from 2010 to 2017, and Xuanwei county, from 2010 to 2016, China. Firstly, the death records of heart failure were corrected to UCOD based on the World Health Organization (WHO) guidelines. Secondly, the records with UCOD remaining to be heart failure were proceeded by coarsened exact matching (CEM) and linear regression (LR), respectively. Finally, the change of cause-specific mortalities before and after redistributed by two methods was calculated, respectively.
Results
The UCOD stated as heart failure was 1556 (0.33%) in Weifang and 226 (0.41%) in Xuanwei, respectively. After redistribution based on the WHO guideline, around 75% of the UCOD records in both cities remained the same. In Weifang, by CEM, heart failure was mainly redistributed to ischemic heart disease (IHD, 45.31%) and hypertensive heart disease (HHD, 21.56%). By LR, 91.20% of heart failure was redistributed to IHD. In Xuanwei, by CEM, heart failure was mainly redistributed to IHD (24.70%), diabetes mellitus and chronic kidney disease (DMCKD 23.25%). By LR, 94.83% of heart failure was redistributed to chronic obstructive pulmonary disease (COPD).
Conclusions
During conducting GC redistribution, careful consideration of which method to choose is necessary, especially for the city-level data. In this study, the CEM approach might probably be more suitable for the city level, compared to LR.
Modeling of Effects of Vibration Parameters on Location-Dependent Initial Relative Density in Powder Metallurgy Capsule Filling
Authors: Sobhani Samaneh , Gandy David , Albert Marc , Tabei Ali , Fan Zhaoyan 
Published: August 2023

Abstract

Power Metallurgy Hot Isostatic Pressing (PM-HIP), as a versatile manufacturing process, has the ability to produce net-shape or near-net-shape components with complicated geometries from materials that are not easily cast, deformed, or welded. In PM-HIP, capsule filling is a critical step to get dimensionally and microstructurally sound outputs. Particularly, capsule filling controls the initial relative density (homogeneity) of the PM-HIP compact. In this study, the pre-consolidation capsule filling process is simulated by the Discrete Element Method (DEM); to capture the impact of vibration parameters, including frequency, amplitude, and vibration direction, on the initial Relative Density (RD). The output of the DEM model was imported into a user subroutine-based finite element of PM-HIP containing a combined constitutive model of compressive and consolidative mechanical behavior of powder. The simulation model was used to quantitatively study the relationships between the vibration parameters and the initial RD of the product. The ultimate results of this work show that the optimal initial RD is obtained at the frequency of 60 Hz. The FEA results illustrate that the compact densifies accordingly with respect to the RD and the uniformity of its distribution.
Distribution, local knowledge and uses of stingless bees (Apidae: Meliponini) assessment and its honey physico-chemical property in selected Woredas of South Omo Zone.
Authors: Ayele Bizuayehu Abebe 
Published: August 2023

Abstract
The study was conducted in Southern Region South Omo Zone Southern Ethiopia to understand agro-ecological distribution of stingless bee and their management practices, socio-economic importance of stingless bees and characterize the physico-chemical properties of honey produced from stingless bees (Meliponula beccarii). Purposive sampling techniques were used to select participants in the FDG. Three FGD per district comprised with 10–12 stingless bee keepers were undertaken for understanding of agro ecological distribution, local knowledge, management practices and socio-economic importance of stingless bees. Honey samples were collected from underground soils through an excavation of natural nests from three representative districts namely Debub Ari, Malee and Bena-Tsemay districts and about 15 honey samples 0.5 liter from each nest was collected for physico-chemical analysis. The two recorded stingless bee species in the study area were Meliponula beccarii and Hypotrigona gribodoi. The two species of stingless bees are varied within their body size, nesting habitats, nest structure and nest site. The productivity of stingless bees varies depending on species, availability of bee forage and the size of the stingless bee colony population. The laboratory result of locally produced stingless bee honey had moisture content, pH, acidity, ash content, Hydroxy Methyl Furfural (HMF), Fructosr, Glucose and Sucrose average contents were 32.59 percent, 3.42 per cent, 113.57 meq/kg, 0.27 g/100 g, 3.51 mq/kg, 29.11%, 29.29% and 2.78%, respectively. Stingless bee keeping practicing in the backyard through trained the beekeepers and using of naturally designed model stingless bee hives.
More may not be better: Enhanced spacecraft shielding may exacerbate cognitive decrements by increasing pion exposures during deep space exploration
Authors: Limoli Charles , VOZENIN MARIE-CATHERINE , Alaghband Yasaman , Drayson Olivia , Piaget Filippo , Leavitt Ron , Allen Barrett , Doan Ngoc-Lien , Rostomyan Tigran , Stabilini Alberto , Reggiani Davide , Hajdas Wojciech , Yukihara Eduardo , Norbury John , Bailat Claude , Desorgher Laurent , Baulch Janet 
Published: August 2023

AbstractThe pervasiveness of deep space radiation remains a confounding factor for the transit of humans through our solar system. Spacecraft shielding both protects astronauts but also contributes to absorbed dose through galactic cosmic ray interactions that produce secondary particles. The resultant biological effects drop to a minimum for aluminum shielding around 20 g/cm2but increase with additional shielding. The present work evaluates for the first time, the impact of secondary pions on central nervous system functionality. The fractional pion dose emanating from thicker shielded spacecraft regions could contribute up to 10% of the total absorbed radiation dose. New results from the Paul Scherrer Institute have revealed that low dose exposures to 150 MeV positive and negative pions, akin to a Mars mission, result in significant, long-lasting cognitive impairments. These surprising findings emphasize the need to carefully evaluate shielding configurations to optimize safe exposure limits for astronauts during deep space travel.
Diagnostic Value of LGE and T1 mapping in Multiple Myeloma patients’heart
Authors: Cui Qian , Yu Jing , Ge Xihong , Gao Guangfeng , Liu Yang , He Qiang , Shen Wen 
Published: August 2023

Abstract

Background
Unidentified heart failure occurs in patients with multiple myeloma when their heart was involved. CMR with late gadolinium enhancement (LGE) and T1 mapping can identify myocardial amyloid infiltrations.
Purpose
To explore the role of CMR with late gadolinium enhancement (LGE) and T1 mapping for detection of multiple myeloma patients’heart.
Material and Methods
A total of 16 MM patients with above underwent CMR (3.0-T) with T1 mapping (pre-contrast and post-contrast) and LGE imaging. In addition, 26 patients with non-obstructive hypertrophic cardiomyopathy and 26 healthy volunteers were compared to age- and sex-matched healthy controls without a history of cardiac disease, diabetes mellitus, or normal in CMR. All statistical analyses were performed using the statistical software GraphPad Prism. The measurement data were represented by median (X) and single sample T test was adopted. Enumeration data were represented by examples and tested was adopted. All tests were two-sided, and P values < 0.05 were considered statistically significant.
Results
In MM group, LVEF was lower than healthy controls and higher than that of non-obstructive hypertrophic cardiomyopathy group, but without statistically significant difference ((%: 49.1 ± 17.5 vs. 55.6 ± 10.3、40.4 ± 15.6, all P > 0.05). Native T1 values of MM group were obviously higher than those of healthy controls and non-obstructive hypertrophic cardiomyopathy group (ms:1462.0 ± 71.3vs. 1269.3 ± 42.3、1324.0 ± 45.1, all P < 0.05). 16 cases (100%) in MM group all had LGE.
Conclusion
LGE joint T1 mapping examination can improve diagnostic accuracy and is extremely meaningful for patient diagnosis and follow-up.
Aberrant Overexpression of Myosin 1b in Glioblastoma Promotes angiogenesis via VEGF-myc-myosin 1b- Piezo1 Axis
Authors: Lv Autor：Weifeng , Yang Fan , Ge Zhengmao , Xin Lele , Zhang Lingxue , Guo Qingdong , Mao Xinggang , Luo Peng , Jiang Xiaofan , Zhang Yanyu 
Published: August 2023

Abstract
Glioblastoma (GBM) is the most aggressive intracranial malignance with poor prognosis, which is attributed to the extreme invasiveness of the tumor. Enhanced angiogenesis is one of the essential hallmarks of GBM, which demonstrates extensive microvascular proliferation and abnormal vasculature. Here, we uncovered the key role of myosin 1b in angiogenesis and vascular abnormality in GBM. Myosin 1b was upregulated in GBM endothelial cells (ECs) compared to their paired non-malignant brain tissue. Knocking down myosin 1b in human/mouse brain endothelial cells inhibited EC migration, proliferation and tube formation. Myosin 1b in ECs are affected by vascular endothelial growth factor (VEGF) signaling through myc. Moreover, myosin 1b promotes angiogenesis via Piezo1 by enhancing Ca2+ influx, in which process VEGF can be the trigger. Our results identified myosin 1b as a key mediator in promoting angiogenesis via Piezol1; suggested that VEGF/myc signaling pathway may be responsible for driving the changes of myosin 1b overexpression in GBM ECs.
Internal fixation of Vancouver B2 periprosthetic femoral fractures: Can it be an alternative to the revision arthroplasty?
Authors: Choi Jung Hwan , Hwang Kyu Tae , Sohn Oog-Jin , Kook Incheol , Park Ki-Chul 
Published: August 2023

Abstract
This study evaluated outcomes of open reduction and internal fixation (ORIF) for the treatment of Vancouver B fracture and analyzed factors affecting prognosis of internal fixation in Vancouver B2 fractures. From January 2009 to August 2021, 14 Vancouver B1 and 22 Vancouver B2 fractures that underwent ORIF were investigated. Clinical outcomes of adequacy of fracture reduction, duration of bone union, femoral stem subsidence were evaluated as well as revision rates and postoperative complications. The average union time for B1 was 14.5 weeks (7–25), the average union time for B2 was 21.0 weeks (8–36). (P = 0.053) Fracture reduction was poor in 1 case in B1 and 10 cases in B2. (p = 0.025) Stem subsidence occurred in 6 cases and revision surgery in 3 cases, all of which occurred in the poor reduction group. Of the 6 cases of stem subsidence, 3 cases were cemented stem and all cements were broken. (p = 0.046). ORIF on Vancouver B2 fracture showed relatively satisfactory results, so it is expected to be an alternative to revision arthroplasty in selected Vancouver B2 fracture. Accurate anatomical reduction during surgery is important to avoid reoperation and femoral stem subsidence. Revision would be better than internal fixation in mantle broken cemented stem Vancouver B2 fracture.
Impact of Negative Emotions on Upper Gastrointestinal Diseases: A Mendel Randomization Study
Authors: Gao Nan , Yu Zhun , Fan Yu , Jiang Xue , Ting Hu 
Published: August 2023

Abstract
Previous observational studies have reported a relationship between negative emotions and upper gastrointestinal disease. However, whether this relationship is causal remains unclear. We aimed to evaluate the causal relationship between negative emotions and upper gastrointestinal diseases using two-sample Mendelian randomization (MR). Three sets of genetic instruments from the database were obtained for analysis, including 12 anxiety-related single nucleotide polymorphisms (SNPs), 46 depression-related SNPs, and 58 nervous-related SNPs. SNPs were filtered using the Phenoscanner website, and the inverse variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum, and outlier test were used for analysis. In inverse variance weighted analysis, anxiety and depression had an effect on gastroduodenal ulcer (p = 2.849 × 10-3, β = 4.908, 95% CI = 1.684–8.132; and p = 6.457 × 10-4, β = 1.767, 95% CI = 0.752–2.782, respectively). Additionally, depression had an effect on diseases of the esophagus, stomach, and duodenum (p = 3.498 × 10-5，β = 0.926，95% CI = 0.487–1.364). Cochran’s Q-derived p-values were 0.457, 0.603, and 0.643, and MR-Egger intercept-derived p-values were 0.697, 0.294, and 0.362, respectively. Here, we show that anxiety and depression have a causal relationship with gastroduodenal ulcers, and depression has a causal relationship with diseases of the esophagus, stomach, and duodenum.
Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders
Authors: gao Shan , Zhao Xiaoshuai , Leng Yan , Xia Zhongyuan 
Published: August 2023

Abstract
Inulin, as a prebiotic, could modulate the gut microbiota. Burn injury leads to gut microbiota disorders and skeletal muscle catabolism. Therefore, whether inulin can improve burn-induced muscle atrophy by regulating microbiota disorders remains unknown. This study aimed to clarify that inulin intake alleviates gut microbiota disorders and skeletal muscle atrophy in burned rats. Rats were divided into the sham group, burn group, prebiotic inulin intervention group, and pseudo-aseptic validation group. A 30% total body surface area (TBSA) third-degree burn wound on dorsal skin was evaluated in all groups except the sham group. Animals in the intervention group received 7 g/L inulin. Animals in the validation group received antibiotic cocktail and inulin treatment. In our study inulin intervention could significantly alleviate the burn-induced skeletal muscle mass decrease and skeletal myoblast cell apoptosis. Inulin intake increased the abundances of Firmicutes and Actinobacteria but decreased the abundance of Proteobacteria. The biosynthesis of amino acids was the most meaningful metabolic pathway distinguishing the inulin intervention group from the burn group, and further mechanistic studies have shown that inulin can promote the phosphorylation of the myogenesis-related proteins PI3K, AKT and P70S6K and activate PI3K/AKT signaling for protein synthesis. In conclusion, inulin alleviated burn induced muscle atrophy through PI3K/AKT signaling and regulated gut microbiota dysbiosis.
Sex differences in the association between epicardial adipose tissue volume and left atrial volume index
Authors: Yamaguchi Satoshi , Maeda Minetaka , Oba Kageyuki , Maimaituxun Gulinu , Arasaki Osamu , Yagi Shusuke , Kusunose Kenya , Soeki Takeshi , Yamada Hirotsugu , Fukuda Daiju , Masuzaki Hiroaki , Sata Masataka , Shimabukuro Michio 
Published: August 2023

Abstract
Background: Sex disparities in the association between epicardial adipose tissue volume (EATV) and cardiovascular disease have been reported. The sex-dependent effects of EATV on left atrial (LA) function have not been elucidated.
Methods: Consecutive 247 subjects (median 65 [interquartile range 57, 75] years; 67% of men) who underwent multi-detector computed tomography without significant coronary artery disease or moderate to severe valvular disease were divided into two groups: patients with sinus rhythm (SR) or atrial fibrillation (AF). Sex differences in the association between the EATV index (EATVI) (mL/m2) and LA volume index (LAVI) in 63 SR (28 men and 35 women) and 184 AF (137 men and 47 women) patients were evaluated using univariate and multivariate regression analyses.
Results: In overall that includes both men and women, the relationship between EATVI and LAVI was not significantly correlated for patients with SR and AF. The relationship between EATVI and LAVI differed between men and women in both SR and AF groups. In SR patients, there was a positive relationship between EATVI and LAVI in men, but not in women. In contrast, in patients with AF, a negative relationship was found between EATVI and LAVI in women, whereas no association was found in men.
Conclusions: We evaluated sex differences in the association between EATVI and LAVI in patients with either SR or AF, and found a positive relationship in men with SR and a negative relationship in women with AF. This is the first report to evaluate sex differences in the relationship between EATVI and LAVI, suggesting that EAT may play a role, at least in part, in sex differences in the etiology of AF.
Sex Differences in the Association of the Severity of Childhood Sexual Abuse with Premarital Sex among Chinese College Students in Luzhou, China
Authors: Zhang Rong , He Jing , Yang Lin , Cao Rongzhe , Liao Maoxu , Lin Xin , Zhou Ping 
Published: August 2023

Abstract
Purpose:The adverse health consequences of premarital sex and childhood sexual abuse (CSA) are both global public health problems. Based on random samples of college students from a Chinese city, this study investigated the relationship between CSA severity and premarital sex among students, with a focus on sex differences.
Methods: A total of 2722 college students from 4 schools in Luzhou were recruited by multistage random sampling. Self-administered questionnaires were used to measure CSA experiences and premaritalsex. Binary logistic regression analyses were conducted to analyze the relationship between CSA and premaritalsex.
Results: The prevalence of CSA was 9.39%, and that of mild, moderate and severe CSA was 4.04%, 2.90% and 2.46% respectively. The premarital sex reporting rate was 22.42%. After adjusting for confounding variables, CSA was positively associated withpremarital sex. Notably, a cumulative effect of CSA on premarital sex was observed among students. Further stratification analyses showed that males who experienced CSA had a higher premarital sex rate than females, and this sex difference was also observed among students with different CSA severity.
Conclusion: CSA and its severity were associated with premarital sex among college students. Furthermore, this association was stronger for males than females. Therefore, it is important to emphasize CSA prevention, especiallyfor boys. These findings can promote understanding of the effects of CSA on premarital sex, and prevention and intervention strategies for CSA should consider CSAseverity and sexdifferences.
Iatrogenic Female Genitourinary Fistula in Uganda: Etiology, Twelve-year trends, and Risk factors among women delivered by cesarean section
Authors: Byamukama Onesmus , Tarnay Christopher , Ainomugisha Brenda , Tibaijuka Leevan , Kajabwangu Rogers , Kalyebara Paul Kato , Lugobe Henry Mark , Geissbühler Verena , Kayondo Musa 
Published: August 2023

Abstract
Background: More than 95% of genito-urinary fistulae in low-income countries are due to prolonged neglected obstructed labour. However, with improving obstetric care and variations in medical training, there seems to be an increase in fistulae resulting from surgical errors.
Objective: The aim of this study was to describe the magnitude and trend of iatrogenic genitourinary fistula at four fistula surgery sites in Uganda from 2010 to 2021 and also determining the risk factors of iatrogenic genitourinary fistula following Cesarean Section (CS).
Methods: A retrospective review of charts for all women who underwent surgery for genitourinary fistula at four regional fistula repair sites in Uganda between 2010 and 2021 was conducted. A fistula was classified as iatrogenic if a participant had any of; ureteric, vesico-cervical, vesico-uterine, or vaginal vault fistula that followed an obstetric or gynecological surgery. Vesico-vaginal and urethro-vaginal fistulae were classified as ischemic irrespective of the mode of delivery. The annual proportions for the obstetric and iatrogenic fistula over the 12-year period were compared. Descriptive analyses and multivariable log binomial regression were performed to determine the independent risk factors.
Results: Over the study period, 521 women had surgery for genito-urinary fistula of which, 169 (32.4%) were iatrogenic. Most of the iatrogenic fistulae followed CS (71%). There was a gradual increase in the proportions of iatrogenic fistulae from 8/52 (9.6%) in 2010 to 38/88 (43.2%) in 2020. The risk factors for iatrogenic fistula following CS were; Grand-multiparity (RR = 5.79; 95% CI: 2.18-15.4; P = 0.001), repeat CS (RR = 4.06; 95% CI: 1.77-9.3; P = 0.001), CS performed by an intern doctor (RR = 4.85; 95% CI: 1.52-15.45; P = 0.008) and CS done at a Health Centre IV (RR = 4.55; 95% CI: 1.2-16.67; P= 0.022).
Conclusion: The magnitude of iatrogenic genitourinary fistula in Uganda is high and most follow CS. There is an observed rising trend in iatrogenic fistula over time. The risk factors for iatrogenic fistula following CS are grandmultiparity, repeat CS, CS performed by intern doctors and CS performed at lower health facilities. There is need for routine in service surgical skills (especially cesarean sections) training for obstetric and gynecological surgery providers.
Rehabilitating instead of rebuilding aged or damaged pre-fabricated concrete buildings in Ukraine: a case for reducing CO2 emissions
Authors: Troian Viacheslav , Volodymyr Gots , Flatt Robert J. , Angst Ueli 
Published: August 2023

Abstract
Recycling the concrete of old and destroyed buildings and using it to build new buildings is a promising technology for post-war Ukraine, but in many cases, it may be economically and environmentally more justified to rehabilitate such buildings.
This article provides an analysis of the state of the housing stock of Ukraine from prefabricated reinforced concrete from the point of view of the possibility of its rehabilitation, mainly based on the forecast of the degree of carbonation of different types of concrete structures in various conditions. Based on the results of this analysis, it can be stated that the service life of internal concrete structures can generally be extended up to 100 years, while external concrete elements after 50 years of operation may already require replacement or repair. A comparative analysis of various reconstruction strategies in Ukraine from the point of view of CO2 emissions is also given. It shows that the rehabilitation of such buildings is the most meaningful strategy.