bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global overview of pharmacy support personnel training programmes: a scoping review protocol
Authors: Hlongwana Simangele , Makhunga Sizwe , Dlungwane Thembelihle 
Published: March 2023

IntroductionA global variation in the pharmacy support personnel training programmes has been observed. The objective of this scoping review is to map out global evidence available on the pharmacy support personnel training programme characteristics, and interface between knowledge, practice and regulatory requirements.Methods and analysisThe scoping review will be undertaken by two independent reviewers. Peer-reviewed journal articles of any study design and grey literature will be included with no publication time limit. All literature published in English focusing on pharmacy support personnel training programmes, entry-level certification requirements, ongoing professional development and apprenticeship will be included. We will search MEDLINE (EBSCOhost), PubMed, CINAHL (EBSCOhost), Web of Science, Academic Search Complete, (EBSCOhost) and Dissertation and Thesis (ProQuest), ProQuest Dissertation and Thesis Global and Google Scholar, and reference list of all included studies. We will also search grey literature from websites of international professional regulatory bodies and associations. All studies that meet the inclusion criteria will be imported into a reference management package (EndNote V.20) that facilitates study selection, screening and de-duplication. Data will be extracted by two independent reviewers using a jointly developed and piloted data charting form. Data items will include skills, knowledge, competencies, admission criteria, content, duration, qualification options, accreditation status, delivery models and approaches. Data extracted from the included studies will be collated, and quantitative results presented using descriptive statistics such as percentages, tables, charts and flow diagrams as appropriate. A narrative account of findings from the literature will be presented following qualitative content analysis of the extracted information using NVivo V.12. Quality appraisal of included studies will not be assessed as the purpose of the scoping review is to give a descriptive global overview of the pharmacy support personnel training programmes, and evidence will also be sourced from grey literature.Ethics and disseminationNo ethical approval is needed for this study as it does not include animals or human participants. The study findings will be disseminated electronically and in print with presentations done at relevant platforms, that is, in peer-reviewed journals, in print and in conferences.RegistrationOpen Science Framework (ofs.i0/r2cdn; registration DOI:https://doi.org/10.17605/OSF.IO/F95MH; internet archive link:https://archive.org/details/osf-registrations-f95mh-v1; registration type: OSF-Standard Pre-Data Collection Registration).
Development and validation of dynamic models to predict postdischarge mortality risk in patients with acute myocardial infarction: results from China Acute Myocardial Infarction Registry
Authors: Lv Junxing , Wang Chuangshi , Gao Xiaojin , Yang Jingang , Zhang Xuan , Ye Yunqing , Dong Qiuting , Fu Rui , Sun Hui , Yan Xinxin , Zhao Yanyan , Wang Yang , Xu Haiyan , Yang Yuejin 
Published: March 2023

ObjectivesThe risk of adverse events and prognostic factors are changing in different time phases after acute myocardial infarction (AMI). The incidence of adverse events is considerable in the early period after AMI hospitalisation. Therefore, dynamic risk prediction is needed to guide postdischarge management of AMI. This study aimed to develop a dynamic risk prediction instrument for patients following AMI.DesignA retrospective analysis of a prospective cohort.Setting108 hospitals in China.ParticipantsA total of 23 887 patients after AMI in the China Acute Myocardial Infarction Registry were included in this analysis.Primary outcome measuresAll-cause mortality.ResultsIn multivariable analyses, age, prior stroke, heart rate, Killip class, left ventricular ejection fraction (LVEF), in-hospital percutaneous coronary intervention (PCI), recurrent myocardial ischaemia, recurrent myocardial infarction, heart failure (HF) during hospitalisation, antiplatelet therapy and statins at discharge were independently associated with 30-day mortality. Variables related to mortality between 30 days and 2 years included age, prior renal dysfunction, history of HF, AMI classification, heart rate, Killip class, haemoglobin, LVEF, in-hospital PCI, HF during hospitalisation, HF worsening within 30 days after discharge, antiplatelet therapy, β blocker and statin use within 30 days after discharge. The inclusion of adverse events and medications significantly improved the predictive performance of models without these indexes (likelihood ratio test p<0.0001). These two sets of predictors were used to establish dynamic prognostic nomograms for predicting mortality in patients with AMI. The C indexes of 30-day and 2-year prognostic nomograms were 0.85 (95% CI 0.83–0.88) and 0.83 (95% CI 0.81–0.84) in derivation cohort, and 0.79 (95% CI 0.71–0.86) and 0.81 (95% CI 0.79–0.84) in validation cohort, with satisfactory calibration.ConclusionsWe established dynamic risk prediction models incorporating adverse event and medications. The nomograms may be useful instruments to help prospective risk assessment and management of AMI.Trial registration numberNCT01874691.
Sodium glucose co-transporter 2 inhibition with empagliflozin on metabolic, cardiac and renal outcomes in recent cardiac transplant recipients (EMPA-HTx): protocol for a randomised controlled trial
Authors: Raven Lisa Mary , Muir Christopher A , Kessler Iglesias Cassia , Bart Nicole K , Muthiah Kavitha , Kotlyar Eugene , Macdonald Peter , Hayward Christopher S , Jabbour Andrew , Greenfield Jerry R 
Published: March 2023

IntroductionCardiac transplantation (CTx) is a life-saving operation that can improve the quality and length of a recipient’s life. Immunosuppression medication, required to prevent rejection, can result in adverse metabolic and renal effects. Clinically significant complications include metabolic effects such as diabetes and weight gain, renal impairment, and cardiac disease such as allograft vasculopathy and myocardial fibrosis. Sodium glucose co-transporter 2 (SGLT2) inhibitors are a class of oral medication that increase urinary excretion of glucose. In patients with type 2 diabetes, SGLT2 inhibitors improve cardiovascular, metabolic and renal outcomes. Similar benefits have been shown in patients with heart failure and reduced ejection fraction irrespective of diabetes status. In patients with post-transplant diabetes mellitus, SGLT2 inhibitors improve metabolic parameters; however, their benefit and safety have not been evaluated in randomised prospective studies. This study will potentially provide a novel therapy to improve or prevent complications (diabetes, kidney failure and heart fibrosis) that occur with immunosuppressive medications.MethodsThe EMPA-HTx study is a randomised, placebo-controlled trial of the SGLT2 inhibitor empagliflozin 10 mg daily versus placebo in recent CTx recipients. One hundred participants will be randomised 1:1 and commence the study medication within 6–8 weeks of transplantation with treatment and follow-up until 12 months after transplantation. Demographic information, anthropomorphic measurements, pathology tests and cardiac magnetic resonance (CMR) scan will be recorded at baseline and follow-up. Patients will be reviewed monthly during the study until 12 months post-CTx and data will be collected for each patient at each study visit. The overall aim of the study is to assess the safety and efficacy of empagliflozin in CTx recipients. The primary outcome is glycaemic improvement measured as change in glycated haemoglobin and/or fructosamine. Key secondary outcomes are cardiac interstitial fibrosis measured by CMR and renal function measured by estimated glomerular filtration rate.Ethics and disseminationThis study has been approved by St Vincent’s Hospital Human Research Ethics Committee (2021/ETH12184). The findings will be presented at national and international scientific meetings and published in peer-reviewed journals.Trial registration numberACTRN12622000978763.
Does melatonin administration reduce the incidence of postoperative delirium in adults? Systematic review and meta-analysis
Authors: Barnes Jonathan , Sewart Emma , Armstrong Richard A , Pufulete Maria , Hinchliffe Robert , Gibbison Ben , Mouton Ronelle 
Published: March 2023

Postoperative delirium (POD) is common. It is associated with increased morbidity and mortality. Many cases may be preventable and melatonin offers promise as a preventative agent.ObjectiveThis systematic review provides an up-to-date synthesis of the evidence on the effect of melatonin in preventing POD.DesignA systematic search of randomised controlled trials of melatonin in POD was run across multiple databases (EMBASE, MEDLINE, CINAHL, PsycINFO) and a clinical trials registry (ClinicalTrials.org) (1 January 1990 to 5 April 2022). Studies examining the effects of melatonin on POD incidence in adults are included. Risk of bias was assessed using the Cochrane risk of bias 2 tool.Outcome measuresThe primary outcome is POD incidence. Secondary outcomes are POD duration and length of hospital stay. Data synthesis was undertaken using a random-effects meta-analysis and presented using forest plots. A summary of methodology and outcome measures in included studies is also presented.ResultsEleven studies, with 1244 patients from a range of surgical specialties were included. Seven studies used melatonin, in variable doses, and four used ramelteon. Eight different diagnostic tools were used to diagnose POD. Time points for assessment also varied. Six studies were assessed as low risk of bias and five as some concern. The combined OR of developing POD in the melatonin groups versus control was 0.41 (95% CI 0.21 to 0.80, p=0.01).ConclusionThis review found that melatonin may reduce the incidence of POD in adults undergoing surgery. However, included studies displayed inconsistency in their methodology and outcome reporting. Further work to determine the optimum regime for melatonin administration, along with consensus of how best to evaluate results, would be beneficial.PROSPERO registration numberCRD42021285019.
Relationship between combat-related traumatic injury and ultrashort term heart rate variability in a UK military cohort: findings from the ADVANCE study
Authors: Maqsood Rabeea , Schofield S , Bennett A N , Bull A MJ , Fear N T , Cullinan P , Khattab A , Boos C J 
Published: March 2023

IntroductionCombat-related traumatic injury (CRTI) has been linked to an increased cardiovascular disease (CVD) risk. The long-term impact of CRTI on heart rate variability (HRV)—a robust CVD risk marker—has not been explored. This study investigated the relationship between CRTI, the mechanism of injury and injury severity on HRV.MethodsThis was an analysis of baseline data from the ArmeD SerVices TrAuma and RehabilitatioN OutComE (ADVANCE) prospective cohort study. The sample consisted of UK servicemen with CRTI sustained during deployment (Afghanistan, 2003–2014) and an uninjured comparison group who were frequency matched to the injured group based on age, rank, deployment period and role in theatre. Root mean square of successive differences (RMSSD) was measured as a measure of ultrashort term HRV via <16 s continuous recording of the femoral arterial pulse waveform signal (Vicorder). Other measures included injury severity (New Injury Severity Scores (NISS)) and injury mechanism.ResultsOverall, 862 participants aged 33.9±5.4 years were included, of whom 428 (49.6%) were injured and 434 (50.3%) were uninjured. The mean time from injury/deployment to assessment was 7.91±2.05 years. The median (IQR) NISS for those injured was 12 (6–27) with blast being the predominant injury mechanism (76.8%). The median (IQR) RMSSD was significantly lower in the injured versus the uninjured (39.47 ms (27.77–59.77) vs 46.22 ms (31.14–67.84), p<0.001). Using multiple linear regression (adjusting for age, rank, ethnicity and time from injury), geometric mean ratio (GMR) was reported. CRTI was associated with a 13% lower RMSSD versus the uninjured group (GMR 0.87, 95% CI 0.80–0.94, p<0.001). A higher injury severity (NISS ≥25) (GMR 0.78, 95% CI 0.69–0.89, p<0.001) and blast injury (GMR 0.86, 95% CI 0.79–0.93, p<0.001) were also independently associated with lower RMSSD.ConclusionThese results suggest an inverse association between CRTI, higher severity and blast injury with HRV. Longitudinal studies and examination of potential mediating factors in this CRTI-HRV relationship are needed.
Equilibration depth and temperature of Neogene alkaline lavas in the Cordillera of Alaska and Canada as a constraint on the lithosphere–asthenosphere boundary
Authors: Canil Dante , Hyndman Roy D. 
Published: March 2023

We have estimated the geochemical equilibration depth and temperature of the widespread Neogene alkaline basalts in the Cordillera of Alaska, Northwest Canada, and in Mexico using geobarometry on bulk compositions that have been minimally differentiated in upward transit. The method has uncertainties of about ±10 km and <70 °C. The regional averages of geochemical equilibration depth for 12 sites in Alaska vary from 50 ± 10 to 84 ± 2 km, somewhat broader than those from the Cordillera in western Canada, western USA, and Mexico. There are no associations of depth with terranes or geological provinces. The final equilibration depth of lavas with the surrounding mantle is concluded to be where partial melt percolating from greater depths’ ponds at the lithosphere–asthenosphere boundary (LAB) until it becomes gravitationally unstable and moves upward in conduits. The top of the low velocity zone from seismic receiver functions, taken to be the LAB in regions of Alaska where Neogene volcanism occurs, varies from 60 to 85 km, covering the range of geochemical equilibration depths of the alkaline lavas. A mean lava equilibration depth of 65 ± 10 km occurs in 24 of 36 alkaline volcanic centers from Alaska to Mexico, and several other global locations, suggesting the LAB may be controlled to a first order by the change in H2O storage capacity and viscosity across the garnet–spinel peridotite phase change at this depth. The scatter and variation in equilibration depths and temperatures are a factor of 2 greater than the recognized uncertainties, and are not yet explained.
Decay of the pseudoscalar glueball into vector, axial-vector, scalar and pseudoscalar mesons
Authors: Eshraim Walaa I. 
Published: March 2023

AbstractWe resume the investigation of the ground-state pseudoscalar glueball,$$J^{PC}=0^{-+}$$JPC=0-+, by computing its two- and three-body decays into vector and axial-vector quark-antiquark meson fields additional to scalar and pseudoscalar mesons through the construction of an interaction chiral Lagrangian that produces these decays. We evaluate the branching ratio, via a parameter-free calculation, by setting the mass of the pseudoscalar glueball to 2.6 GeV as predicted by lattice QCD simulations. We duplicate the computation for the branching ratios for a pseudoscalar glueball mass 2.37 GeV which matches to the measured mass of the resonanceX(2370) in the BESIII experiment. The present channels and states are potentially reached and are interesting for the running BESIII and Belle-II experiments and the planned PANDA experiment at FAIR/GSI which will be able to detect the pseudoscalar glueball within the accessible energy range.
Observational signatures of Schwarzschild-MOG black holes in scalar–tensor–vector gravity: images of the accretion disk
Authors: Hu Shiyang , Deng Chen , Guo Sen , Wu Xin , Liang Enwei 
Published: March 2023

AbstractThe present paper contains the investigations with respect to the optical appearance, redshift distribution, and observed energy flux of the thin accretion disk described by the Novikov-Thorne model in modified gravity (MOG) proposed by Moffat. The results show that the gravity coupling parameter$$\alpha $$αplays an indispensable role in the size of direct and secondary images of the accretion disk, while the image profile is mainly affected by the observational angles. In addition, an increase of the parameter$$\alpha $$αleads to that of the redshift factor, but a decrease in the radiation energy flux of the accretion disk. These results are due to the enhancement of the parameter$$\alpha $$αthat strengthens the black hole’s gravitational effects. By comparing the accretion disk images of the Schwarzschild-MOG black hole, the Schwarzschild black hole, and the Reissner–Nordström black hole, we point out that the Schwarzschild-MOG black hole exhibits the largest inner shadow and the lowest luminosity. This finding provides a potential way to distinguish Schwarzschild-MOG black holes from their counterparts in General Relativity.
Absorption edge characteristics of β-Ga2O3 single crystal
Authors: Gao Shang 
Published: March 2023

The intrinsic absorption edge of a [Formula: see text] single crystal is examined by spectroscopic ellipsometry. An absorption model consisting of five parameters including absorption amplitude, bandgap energy, Urbach energy and two power exponents is developed to describe the absorption characteristics of the [Formula: see text] single crystal. The anisotropic bandgap energies obtained from the model are 4.938, 5.030 and 5.100 eV, respectively. These values obtained from the model agree well with values derived from the first derivative maximum of k and maximum of n method.
The Bowland Shale Formation in the Blacon Basin: palaeoecology and resource potential
Authors: Hennissen Jan A. I. , Emmings Joseph F. , Raine Robert , Hough Edward , Vane Christopher H. , Page Max , Moss-Hayes Vicky , Lacey Jack , Leng Melanie 
Published: March 2023

Abstract

We evaluated the unconventional hydrocarbon potential of the Holywell Shale Formation, a lateral equivalent of the Bowland Shale Formation deposited in the Blacon Basin. Two cores with Arnsbergian–Chokierian and Kinderscoutian (Namurian, Late Mississippian–Early Pennsylvanian) ages from the Ellesmere Port 1 borehole were sampled for palynological, stable isotope, Rock-Eval 6 pyrolysis and ichnofacies analyses. The study was designed to provide boundary conditions for parameters that are under-represented in the public domain and hamper accurate resource assessments: thermal maturity (through mean random vitrinite reflectance,
R
r
), present-day organic matter content, kerogen type, original hydrogen index and original organic matter content. Our results show that the Arnsbergian Core 2 has been buried to a depth equivalent to the bottom of the oil window to the top of the gas window (%
R
r
= 1.15%–1.29%). The Kinderscoutian Core 1 is too immature to have generated any natural gas (%
R
r
= 0.91–1.03%). Furthermore, kerogen typing and ichnofacies analysis show that the Bowland Shale Formation is very heterogeneous, with organic matter originating from terrestrial and marine sources. Five palynofacies assemblages are described that range in basin setting from proximal and oxic to distal and anoxic with evidence of episodic connections to the open ocean. The combination of heterogeneity and low thermal maturity restricts the thickness of the Bowland Shale Formation in the Blacon Basin that is prospective for unconventional hydrocarbons. Our results show that these Carboniferous mudstones should not be treated as uniform units with uniform composition and maturity in basin modelling and resource estimates. This undoubtedly has repercussions for future exploration because the contrasting composition and density of the materials making up the Bowland Shale Formation may complicate extraction, while the thermal maturity window significantly narrows the prospective interval.
Petrology of the 2020–21 effusive to explosive eruption of La Soufrière Volcano, St Vincent: insights into plumbing system architecture and magma assembly mechanism
Authors: Weber Gregor , Blundy Jon , Barclay Jenni , Pyle David M. , Cole Paul , Frey Holli , Manon Matthew , Davies Bridie V. , Cashman Katharine 
Published: March 2023

Abstract

The 2020–21 eruption of La Soufrière, St Vincent began with extrusion of a viscous lava dome, which was destroyed upon transition to a major explosive phase. Here we present petrological data to reconstruct the processes leading up to these events. Bulk-rock SiO
2
contents range from 52.8 to 55.4 wt%, classifying the lava and the subsequent scoria as basaltic andesite, the latter being slightly more mafic. Macrocrystal chemistry and modes (plag–cpx–opx–tmt–ol) and crystallinity (45–50 vol%) are largely identical for both phases of the eruption. Pyroxenes are homogenous and precipitated mostly from andesitic melts. Conversely, plagioclase shows strong normal zonation resulting from magma ascent and stalling at multiple crustal levels. Clinopyroxene thermobarometry reveals that crystallization predominantly took place between 8 and 13 km depth at temperatures of

997

−
35

+
18

∘

C

. A lack of evidence for mafic recharge and changes in volatile content and the omnipresence of xenoliths, suggests pre-eruptive destabilization of an andesitic–dacitic melt pocket that disrupted and entrained antecedent mush. Olivine diffusion profiles show that this interaction preceded the onset of eruption. Low dissolved sulfur contents (≤270 ppm S) place constraints on the total SO
2
gas release. Melt–mush disruption appears to be a dominant driver of eruptions at La Soufrière.
Comprehensive DNA Methylation Analysis Indicates That Pancreatic Intraepithelial Neoplasia Lesions Are Acinar-Derived and Epigenetically Primed for Carcinogenesis
Authors: Lo Emily K.W. , Mears Brian M. , Maurer H. Carlo , Idrizi Adrian , Hansen Kasper D. , Thompson Elizabeth D. , Hruban Ralph H. , Olive Kenneth P. , Feinberg Andrew P. 
Published: March 2023

AbstractPancreatic ductal adenocarcinoma (PDAC) is believed to arise from the accumulation of a series of somatic mutations and is also frequently associated with pancreatic intraepithelial neoplasia (PanIN) lesions. However, there is still debate as to whether the cell type-of-origin of PanINs and PDACs in humans is acinar or ductal. As cell type identity is maintained epigenetically, DNA methylation changes during pancreatic neoplasia can provide a compelling perspective to examine this question. Here, we performed laser-capture microdissection on surgically resected specimens from 18 patients to isolate, with high purity, DNA for whole-genome bisulfite sequencing from four relevant cell types: acini, nonneoplastic ducts, PanIN lesions, and PDAC lesions. Differentially methylated regions (DMR) were identified using two complementary analytical approaches: bsseq, which identifies any DMRs but is particularly useful for large block-like DMRs, and informME, which profiles the potential energy landscape across the genome and is particularly useful for identifying differential methylation entropy. Both global methylation profiles and block DMRs clearly implicated an acinar origin for PanINs. At the gene level, PanIN lesions exhibited an intermediate acinar-ductal phenotype resembling acinar-to-ductal metaplasia. In 97.6% of PanIN-specific DMRs, PanIN lesions had an intermediate methylation level between normal and PDAC, which suggests from an information theory perspective that PanIN lesions are epigenetically primed to progress to PDAC. Thus, epigenomic analysis complements histopathology to define molecular progression toward PDAC. The shared epigenetic lineage between PanIN and PDAC lesions could provide an opportunity for prevention by targeting aberrantly methylated progression-related genes.Significance:Analysis of DNA methylation landscapes provides insights into the cell-of-origin of PanIN lesions, clarifies the role of PanIN lesions as metaplastic precursors to human PDAC, and suggests potential targets for chemoprevention.