bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pledgeability and Asset Prices: Evidence from the Chinese Corporate Bond Markets
Authors: CHEN HUI , CHEN ZHUO , HE ZHIGUO , LIU JINYU , XIE RENGMING 
Published: July 2023

ABSTRACTWe provide causal evidence on the value of asset pledgeability by exploiting a unique feature of Chinese corporate bond markets: bonds with identical fundamentals are traded on two segmented markets with different rules for repo transactions. Using a policy shock that rendered AA+ and AA bonds ineligible for repo on one market only, we compare how bond prices changed across markets and rating classes around this event. When the haircut increases from 0% to 100%, bond yields increase by 39 bps to 85 bps. These estimates help us infer the magnitude of the shadow cost of capital in China.
Investment case for the prevention and reduction of childhood and adolescent overweight and obesity in Mexico
Authors: Brero Mauro , Meyer Christina L. , Jackson‐Morris Angela , Spencer Garrison , Ludwig‐Borycz Elizabeth , Wu Daphne , Espinosa De Candido Anabel Fiorella , Ferre Eguiluz Maria Isabel , Bonvecchio Arenas Anabelle , Jewell Jo , Nugent Rachel 
Published: July 2023

SummaryDespite efforts to curb the rise in Mexico's child and adolescent overweight and obesity rates, prevalence in Mexico has grown by 120% since 1990 to 43.3% in 2022. This investment case identifies policies that will produce the largest returns for Mexico. The investment case model builds beyond a cost‐of‐illness analysis by predicting the health and societal economic impact of implementing child and adolescent overweight and obesity interventions in a cohort aged 0–19 from 2025 to 2090. The Markov model's impacts include healthcare expenditures, years of life lost, and reduced wages and productivity. We projected and compared costs in a status quo scenario to an intervention scenario to estimate cost savings and calculate return‐on‐investment (ROI). Total lifetime health and economic costs amount to USD 1.8 trillion—USD 30 billion on average per year. Implementing five interventions can reduce lifetime costs by approximately 7%. Each intervention has a low cost per disability‐adjusted life year averted over 30‐year, 50‐year, and lifetime horizons. The findings demonstrate that a package of interventions mitigating child and adolescent overweight and obesity offers a strong ROI. The novel investment case methods should be applied to other countries, particularly low‐ and middle‐income countries.
Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids
Authors: Gugu Thaddeus H. , Agu Geraldine C. , Uronnachi Emmanuel M. , Chime Salome A. 
Published: July 2023

AbstractIbuprofen is a member of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAIDs) with anti-inflammatory, analgesic, and antipyretic activities used to relieve a variety of pains. The objective of this study was to formulate, characterize and evaluate the in vitro and in vivo properties of ibuprofen formulated as solid lipid microspheres (SLMs) for enhanced delivery. The mixtures of Irvingia wombolu fat (IRW) and moringa oil (MO) each with Phospholipon® 90G (PL90G) at the ratio of 2:1 w/w were prepared by fusion, characterized and used to prepare SLMs. The SLMS were thereafter evaluated using the following parameters: particle size and morphology, stability, and encapsulation efficiency EE (%). In vitro release was carried out in phosphate buffer (pH 7.4). The ibuprofen based SLMs were also evaluated for anti-inflammatory and anti-ulcer effects using animal models. The pH showed significant increase after two months of formulation with a maximum value of 6.4 while the EE obtained were 95.6, 89.4 and 61.6% for SLMs formulated with lipid matrix of Phospholipon® 90G (1% and 2%), and MO (1%) respectively. The in vitro release showed maximum release of 87.8 and 98.97% of the two different lipid-based formulations while anti-inflammatory effect was up to 89.90% after 5 h of inducing inflammation. The SLMs did not show any lesion thus conferring gastroprotection on the formulations. The SLMs exhibited good anti-inflammatory property with gastroprotective action.
The association of breast feeding for at least six months with hemodynamic and metabolic health of women and their children aged three years: an observational cohort study
Authors: Pathirana Maleesa M. , Andraweera Prabha H. , Aldridge Emily , Harrison Madeline , Harrison Jade , Leemaqz Shalem , Arstall Margaret A. , Dekker Gustaaf A. , Roberts Claire T. 
Published: July 2023

Abstract
Background
Breastfeeding is important for both mother and child in reducing risk of future cardiovascular disease. Therefore, it may be an effective method to improve cardio-metabolic health, particularly those who are exposed to pregnancy complications which increase later CVD risk for both mother and child. The aim of this study is to assess differences in cardiometabolic health at three years postpartum in mothers who breastfed for at least six months and their children compared to those who did not.

Methods
Women and children from the Screening Tests to Predict Poor Outcomes of Pregnancy (STOP) study (2015–2017) were invited to attend a health check-up at three years postpartum. Women’s breastfeeding status at least six months postpartum was ascertained through their child health record. Anthropometric and hemodynamic measurements were taken from women and their children. A fasting blood sample was taken from women to measure blood glucose and lipids.

Results
A total of 160 woman-child dyads were assessed in this study. Women who breastfed for at least six months had significantly lower maternal BMI, systolic blood pressure, diastolic blood pressure, mean arterial pressure, central systolic blood pressure, and central diastolic blood pressure than those who did not and this did not change after adjusting for BMI and socioeconomic index in early pregnancy, prenatal smoking and maternal age in early pregnancy. Subgroup analysis on women who had one or more pregnancy complications during the index pregnancy (i.e. preeclampsia, gestational hypertension, delivery of a small for gestational age infant, delivery of a preterm infant, and/or gestational diabetes mellitus) demonstrated that women who breastfed for at least six months had significantly lower maternal systolic and diastolic blood pressures, serum insulin and triglycerides, and higher HDL cholesterol. There were no differences in child anthropometric or hemodynamic variables at three years of age between those children who had been breastfed for at least six months and those who had not.

Conclusion
Breastfeeding for at least six months may reduce some maternal; cardiovascular risk factors in women at three years postpartum, in particular, in those who have experienced a complication of pregnancy.

Trial registration
ACTRN12614000985684 (12/09/2014).
An interpretable MRI-based radiomics model predicting the prognosis of high-intensity focused ultrasound ablation of uterine fibroids
Authors: Li Chengwei , He Zhimin , Lv Fajin , Liu Yang , Hu Yan , Zhang Jian , Liu Hui , Ma Si , Xiao Zhibo 
Published: July 2023

Abstract
Background
Accurate preoperative assessment of the efficacy of high-intensity focused ultrasound (HIFU) ablation for uterine fibroids is essential for good treatment results. The aim of this study was to develop robust radiomics models for predicting the prognosis of HIFU-treated uterine fibroids and to explain the internal predictive process of the model using Shapley additive explanations (SHAP).

Methods
This retrospective study included 300 patients with uterine fibroids who received HIFU and were classified as having a favorable or unfavorable prognosis based on the postoperative nonperfusion volume ratio. Patients were divided into a training set (N = 240) and a test set (N = 60). The 1295 radiomics features were extracted from T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (CE-T1WI) scans. After data preprocessing and feature filtering, radiomics models were constructed by extreme gradient boosting and light gradient boosting machine (LightGBM), and the optimal performance was obtained by Bayesian optimization. Finally, the SHAP approach was used to explain the internal prediction process.

Results
The models constructed using LightGBM had the best performance, and the AUCs of the T2WI and CE-T1WI models were 87.2 (95% CI = 87.1–87.5) and 84.8 (95% CI = 84.6–85.7), respectively. The use of SHAP technology can help physicians understand the impact of radiomic features on the predicted outcomes of the model from a global and individual perspective.

Conclusion
Multiparametric radiomic models have shown their robustness in predicting HIFU prognosis. Radiomic features can be a potential source of biomarkers to support preoperative assessment of HIFU treatment and improve the understanding of uterine fibroid heterogeneity.

Clinical relevance statement
An interpretable radiomics model can help clinicians to effectively predict the prognosis of HIFU treatment for uterine fibroids. The heterogeneity of fibroids can be characterized by various radiomics features and the application of SHAP can be used to visually explain the prediction process of radiomics models.

Graphical Abstract
Validation and reliability for the updated REAP-S dietary screener, (Rapid Eating Assessment of Participants, Short Version, v.2)
Authors: Shankar Viswanathan , Thompson Kathryn H. , Wylie-Rosett Judith , Segal-Isaacson C. J. 
Published: July 2023

Abstract
Background
The American Heart Association (AHA) chose the REAP-S dietary screener in 2020 as one of three US dietary screeners recommended for integrating dietary assessment into clinical care. The REAP-S v.2 is an updated version that is aligned with the 2020–2025 US Dietary Guidelines and is easily incorporated into electronic medical records and taught to medical students.

Methods
The University of New England, Institutional Review Board, approved the study protocol. We evaluated the reliability and validity of the REAP-S v.2 scale by having first-year medical students (n = 167) complete both the REAP-S v.2 and a three-day food record and then analyzing their data with the following statistical techniques: Internal consistency was measured using Cronbach's alpha. Construct validity was assessed with exploratory factor analysis. Criterion validity was evaluated using analysis of variance (ANOVA) that explored the associations between REAP-S v.2 scale item responses and selected nutrient estimates from the food record analyses. The hierarchical cluster analysis classified healthy and unhealthy diet grouping under each subscale. Further using these groupings, cut points for "good" and "bad" diets for each of the three main REAP-S v.2 subscales (Food Sufficiency/Food Insufficiency; Healthy Eating Pattern and Low Nutrient Density Foods) were calculated using receiver operating characteristics (ROC) analysis. Students analyzed their three-day food intake records using an online USDA application called SuperTracker.

Results
The Cronbach’s alpha measuring internal consistency was acceptable for the overall scale at 0.71. The exploratory factor analysis extracted three factors that roughly paralleled the three main subscales, suggesting construct validity. Most selected food record-derived nutrient values were significantly associated with scale items confirming criterion validity. The score cut points suggest that dietary counseling might be needed at ≤ 8, ≤ 10, and ≤ 16 for the above subscales.

Conclusion
The REAP-S v.2 is intended for clinicians to use as a brief dietary screener with their patients. Tested in a population of first-year medical students, the REAP-S v.2 brief dietary screener showed acceptable internal consistency, criterion, and construct validity. It is easily scored and incorporated into the electronic medical record.
Short Communication: Diversity, distribution and potential uses of Ficus spp. in Sumatra, Indonesia
Authors: DEWI SILVIA INDRA , SYAMSUARDI SYAMSUARDI , NURAINAS NURAINAS 
Published: July 2023

Abstract. Dewi SI, Syamsuardi, Nurainas. 2023. Short Communication: Diversity, distribution and potential uses of Ficus spp. in Sumatra, Indonesia. Biodiversitas 24: 3431-3438. The Andalas Herbarium is the largest herbarium in Sumatra, with specimens totaling 34,850 sheets and 2011 species of vascular plants from 126 familiesand 491 genera. It serves as a valuable resource for the study of biodiversity, particularly on the island of Sumatra. The purpose of this study was to examine the diversity, distribution, and potential uses of Ficus spp. in Sumatra based on Andalas Herbarium (ANDA) specimens. A total of 2300 herbarium sheets were examined, resulted in 53 species of Ficus spp. collected at Andalas Herbarium. The Ficus at Andalas Herbarium consists of six subgenera, namely Ficus, Pharmacosycea, Sycidium, Sycomorus, Synoecia, and Urostigma. The subgenus with the highest number of species is Urostigma while the lowest is Pharmacosycea.Our examination found the new occurrence of F. rubrocuspidata in West Sumatra. The herbarium specimens were mostly collected from Padang city and least collected from Kampar District. In general, all species of Ficus were found in lowlands and some species were found in highlands. Among the Ficus species recorded at Andalas Herbarium, 63% have the potential uses as medicine, ornamental plants, or consumed as young shoots and fruit.
Healthy eating and physical activity: Analysing Soweto’s young adults’ perspectives with an intersectionality lens
Authors: Mukoma Gudani , Bosire Edna N , Klingberg Sonja , Norris Shane A 
Published: July 2023

Background and objectives
Non-communicable diseases (NCDs) are taking a toll on Africa’s youth at younger ages than in other regions. These are attributed to risk factors that usually advance in adolescence, such as unhealthy diets and reduced physical activity. Young adults in South Africa, particularly women, tend to be sedentary, consume energy-dense diets low in micronutrients, and are more likely to develop NCDs much earlier in life than those in high-income countries. With an intersectionality perspective, this study explored young adults’ barriers and solutions to addressing these risk factors in Soweto.

Setting
Soweto, Johannesburg, South Africa, is one of the most well-known historically disadvantaged townships known for its established communities, and socioeconomic and cultural diversity. Design: A qualitative investigation utilising focus group discussions (FGDs) with a topic guide. FGDs were transcribed verbatim and thematically analysed using a combination of deductive and inductive approaches.

Participants
15 Men and 15 women 18–24 years of age living in Soweto (n = 30). Results: South African young adults have a basic understanding of the significance of nutrition, exercise, and their ties to health. However, numerous barriers (like taste, affordability and crime) to such behaviours were reported, arising from the participants’ personal, domestic, social, and local community levels. Young women experienced sexism and had safety concerns while exercising in the streets, while young men tended to describe themselves as lazy to engage in exercise as they find it boring.

Conclusions
Young adults face a multitude of intersecting barriers, making it difficult to adopt or sustain health-promoting behaviours. It is important that potential solutions focus on the intersections of barriers to healthy eating and physical activity in order to provide more realistic support for such behaviours.
Antivenom preclinical efficacy testing against Asian snakes and their availability in Asia: A systematic review
Authors: Soopairin Sutinee , Patikorn Chanthawat , Taychakhoonavudh Suthira 
Published: July 2023

BackgroundCross-neutralizing strategy has been applied to improve access to antivenoms, a key to reducing mortality and disability of snakebite envenoming. However, preclinical studies have been conducted to identify antivenoms’ cross-neutralizing ability when clinical studies may not be considered ethical. Therefore, this study aimed to identify and summarize scattered evidence regarding the preclinical efficacy of antivenoms against Asian snakes.Methodology/Principle findingsIn this systematic review, we searched for articles published until May 30, 2022, in PubMed, Scopus, Web of Science, and Embase. Preclinical studies that reported the available antivenoms’ neutralizing ability against Asian snake lethality were included. Quality assessment was performed using the Systematic Review Centre for Laboratory animal Experimentation’s risk of bias tool and the adapted the Animal Research ReportingIn VivoExperiments guidelines. The availability of effective antivenoms against Asian snakes was analyzed by comparing data from included studies with snakebite-information and data platforms developed by the World Health Organization. Fifty-two studies were included. Most studies assessed the antivenom efficacy against snakes from Southeast Asia (58%), followed by South Asia (35%) and East Asia (19%). Twenty-two (49%) medically important snakes had antivenom(s) with confirmed neutralizing ability. Situation analyses of the availability of effective antivenoms in Asia demonstrated that locally produced antivenoms did not cover all medically important snakes in each country. Among countries without local antivenom production, preclinical studies were conducted only in Bangladesh, Sri Lanka, and Malaysia. Risk of bias assessment was limited in some domains because of unreported data.Conclusions/SignificanceCross-neutralizing of antivenoms against some medically important snakes in Asia was confirmed. This strategy may improve access to geographically effective antivenoms and bypass investment in novel antivenom development, especially in countries without local antivenom production. A database should be developed to aid the development of a snakebite-information system.
Understanding the mechanism of red light-induced melatonin biosynthesis facilitates the engineering of melatonin-enriched tomatoes
Authors: Zhang Yang , Zhang Zixin , Zhang Xin , Chen Yuting , Jiang Wenqian , Zhang Jing , Wang Jiayu , Wu Yanjun , Wang Shouchuang , Yang Xiao , Liu Mingchun 
Published: July 2023

Abstract
Melatonin is a functionally conserved broad-spectrum physiological regulator that exists in most biological organisms in nature. Enrichment of tomato fruit with melatonin not only enhances its agronomic traits but also provides extra health benefits. In this study, we elucidate the full melatonin biosynthesis pathway in tomato fruit by identification of novel biosynthetic genes that encode caffeic acid O-methyltransferase 2 (SlCOMT2) and N-acetyl-5-hydroxytryptamine-methyltransferases 5/7 (SlASMT5/7). We further revealed that red light supplement has significantly enhanced melatonin content in tomato fruit. This induction relies on the “serotonin—N-acetylserotonin—melatonin” biosynthesis route via the SlphyB2-SlPIF4-SlCOMT2 module. Based on the regulatory mechanism, we targeted the binding motif of SlPIF4 in the promoter of SlCOMT2 to design the gene-editing strategy and significantly enhanced the production of melatonin in tomato fruit. Our study provides a good example of how the understanding of plant metabolic pathways responding to environmental factors can guide the engineering of new health-promoting food.
Trends in medically serious suicide attempts before and after the COVID-19: a four-year retrospective analysis (2018-2022)
Authors: Beneria Anna , Marte Luis , Quesada-Franco Marta , García-González Sara , Restoy Damià , Pérez-Galbarro Citlalli , Santesteban Olga , Ramos Rosa , Ramos-Quiroga Josep Antoni , Braquehais María Dolores 
Published: July 2023

Abstract

Background
Suicide has become a first-order public health concern after the negative impact of COVID-19 on the general population’s mental health. Several studies have analyzed the trends in suicide attempts (SA) before and after the onset of the pandemic, but few studies focus on the impact of the pandemic on medically serious suicide attempts (MSSA).
Methods
Participants were 396 hospitalized individuals ≥ 16 years old who made MSSA identified retrospectively through a review of e-medical records between 2018 and 2022 ("pre-COVID-19" and “COVID” periods). The two groups were compared on sociodemographic and clinical variables using Chi-square or Exact Fisher’s tests for categorical variables and a Mann-Whitney test for continuous variables. To study the variation in MSSA over time, MSSA were aggregated monthly. Joinpoint regression analyses were used to assess time trends.
Results
A sample of 161 MSSA patients, 80 women and 81 men, were selected from 396 admissions after a suicide attempt (SA) in the four years (n = 169 pre-COVID period vs. n = 199 COVID period). Sixty-eight patients with MSSA were admitted during the first period, and 93 during the COVID period. MSSA patients were more likely to be admitted to an intensive care unit during the COVID period than during the pre-COVID period (OR = 3.4620; CI 95%=1.7305–6.9260).
Conclusions
This study highlights the need for research on suicide risk during and after crisis periods, such as the COVID-19 pandemic. It provides valuable knowledge on the incidence of SA needing hospitalization, MSSA, and highly severe MSSA for four years before and after the pandemic onset.
Homoharringtonine, a novel senotherapeutic, mitigates diet- and age-associated obesity and insulin resistance
Authors: Sung Hoon-Ki , Kim Eok-Cheon , Jung Han-Byul , Cha Hye-Na , Patel Yash , Lee Ju Hee , Choi Minah , Park Yu-kyoung , Park Soyoung , Kim Il-Kug , Pickel Lauren , Shin Min-Gyeong , Kim Jae-Ryong , Park So-Young 
Published: July 2023

Abstract
The accumulation of senescent cells in white adipose tissue (WAT) is closely associated with the functional decline of WAT and plays a causal role in the pathogenesis of metabolic diseases. Therefore, the elimination of senescent cells in WAT holds promise for the treatment and prevention of age-related metabolic diseases. Using a drug-repositioning strategy for 2,150 clinically applied compounds, we discover that homoharringtonine (HHT), an FDA-approved anti-leukemic drug, manifests senotherapeutic activity in senescent human dermal fibroblasts and murine and human preadipocytes in vitro with minimal cytotoxicity on young, healthy cells. HHT treatment prevents diet- or age-induced metabolic abnormalities in mice through improved WAT function and reduced WAT inflammation by targeting senescent adipocytes and preadipocytes. Moreover, HHT treatment attenuates age-associated phenotypes of human adipose tissue. Importantly, we found that HHT treatment promotes healthspan in mouse model of physiological aging. Our study provides evidence of the novel senotherapeutic potential of HHT in age- and obesity-related metabolic dysfunctions.