bluuebunny/crossref_metadata_2025_split huggingface dataset:
The NLRP3 inflammasome is involved in resident intruder paradigm-induced aggressive behaviors in mice
Authors: Yu Qingying , Liu Molin , Dai Weibo , Xiong Yu , Mu Xiangyu , Xia Mengyao , Li Yanling , Ma Shan , Su Yongtao , Wu Jibiao , Liu Chuanguo , Xie Yicheng , Zhao Tingting , Lu Aimei , Weng Ning , Zheng Feng , Sun Peng 
Published: January 2023

Background: Aggressive behaviors are one of the most important negative behaviors that seriously endangers human health. Also, the central para-inflammation of microglia triggered by stress can affect neurological function, plasticity, and behavior. NLRP3 integrates stress-related signals and is a key driver of this neural para-inflammation. However, it is unclear whether the NLRP3 inflammasome is implicated in the development of aggressive behaviors.Methods: First, aggressive behavior model mice were established using the resident intruder paradigm. Then, aggressive behaviors were determined with open-field tests (OFT), elevated plus-maze (EPM), and aggressive behavior tests (AT). Moreover, the expression of P2X7R and NLRP3 inflammasome complexes were assessed by immunofluorescence and Western blot. The levels of NLRP3 and inflammatory cytokines were evaluated using enzyme-linked immunosorbent assay (ELISA) kits. Finally, nerve plasticity damage was observed by immunofluorescence, transmission electron microscope, and BrdU staining.Results: Overall, the resident intruder paradigm induced aggressive behaviors, activated the hippocampal P2X7R and NLRP3 inflammasome, and promoted the release of proinflammatory cytokines IL-1β in mice. Moreover, NLRP3 knockdown, administration of P2X7R antagonist (A804598), and IL-1β blocker (IL-1Ra) prevented NLRP3 inflammasome-driven inflammatory responses and ameliorated resident intruder paradigm-induced aggressive behaviors. Also, the resident intruder paradigm promoted the activation of mouse microglia, damaging synapses in the hippocampus, and suppressing hippocampal regeneration in mice. Besides, NLRP3 knockdown, administration of A804598, and IL-1Ra inhibited the activation of microglia, improved synaptic damage, and restored hippocampal regeneration.Conclusion: The NLRP3 inflammasome-driven inflammatory response contributed to resident intruder paradigm-induced aggressive behavior, which might be related to neuroplasticity. Therefore, the NLRP3 inflammasome can be a potential target to treat aggressive behavior-related mental illnesses.
Sprint skating profile of competitive female bandy players: An analysis of positional and playing-level differences
Authors: van den Tillaar Roland , Pojskic Haris , Andersson Håkan 
Published: January 2023

There is no research examining female bandy players, which creates a gap of knowledge of female skating performance and its determinants with male skating performance, not only in bandy but also in exercise science in general. Therefore, the aim of this explorative study was to investigate position and playing-level differences in the sprint skating performance and anthropometrics of 74 elite female bandy players (age: 18.9 ± 4.1 years; height: 1.67 ± 0.06 m; body mass: 63.2 ± 7.4 kg). Participants were categorised according to playing level (26 elite and 48 junior elite players) and position (22 defenders, 35 midfielders, and 17 forwards). They were tested on their anthropometric characteristics and sprint linear skating profile over 80 m with the split times measured at 10, 20, 40, 50, 60, 70, and 80 m to calculate the average velocities between these different 10 m intervals. Results revealed that elite players had more training experience, were heavier, could accelerate faster, and reached a higher maximal velocity than the junior elite players (9.52 ± 0.37 vs 8.84 ± 0.40 m/s, respectively). In general, defenders were heavier than forwards, and the elite forwards accelerated faster in the first 10 m than the midfielders (p = 0.041). In summary, playing level and position, body mass, and training experience modulated skating sprint performance. The findings suggest that female junior-level players should spend more time developing skating sprint and acceleration abilities to meet the specific demands of playing at the elite level. Moreover, the coaches and professionals who work with female bandy players should be aware that the development of acceleration ability is more important for forwards.
Small extracellular vesicles released from germinated kiwi pollen (pollensomes) present characteristics similar to mammalian exosomes and carry a plant homolog of ALIX
Authors: Suanno Chiara , Tonoli Elisa , Fornari Enzo , Savoca Maria P. , Aloisi Iris , Parrotta Luigi , Faleri Claudia , Cai Giampiero , Coveney Clare , Boocock David J. , Verderio Elisabetta A. M. , Del Duca Stefano 
Published: January 2023

IntroductionIn the last decade, it has been discovered that allergen-bearing extracellular nanovesicles, termed “pollensomes”, are released by pollen during germination. These extracellular vesicles (EVs) may play an important role in pollen-pistil interaction during fertilization, stabilizing the secreted bioactive molecules and allowing long-distance signaling. However, the molecular composition and the biological role of these EVs are still unclear. The present study had two main aims: (I) to clarify whether pollen germination is needed to release pollensomes, or if they can be secreted also in high humidity conditions; and (II) to investigate the molecular features of pollensomes following the most recent guidelines for EVs isolation and identification.MethodsTo do so, pollensomes were isolated from hydrated and germinated kiwi (Actinidia chinensis Planch.) pollen, and characterized using imaging techniques, immunoblotting, and proteomics.ResultsThese analyses revealed that only germinated kiwi pollen released detectable concentrations of nanoparticles compatible with small EVs for shape and protein content. Moreover, a plant homolog of ALIX, which is a well-recognized and accepted marker of small EVs and exosomes in mammals, was found in pollensomes.DiscussionThe presence of this protein, along with other proteins involved in endocytosis, is consistent with the hypothesis that pollensomes could comprehend a prominent subpopulation of plant exosome-like vesicles.
Measuring the dosage of brief and skill-targeted social-emotional learning (SEL) activities in humanitarian settings
Authors: Wu Zezhen , Brown Lindsay , Kim Ha Yeon , Yoshikawa Hirokazu , Aber J. Lawrence 
Published: January 2023

IntroductionIn humanitarian settings, social-emotional learning (SEL) programs for children are often delivered using a field-feasible approach where the programs are more easily deployable and adaptable in the field, require minimal training, and depend less on the strict sequence and structure of the program components to elicit the intended treatment effect. However, evidence is lacking on what aspects of this implementation approach enable the SEL programming to be more beneficial to children’s SEL development.MethodIn this study, we propose and evaluate measures for three dimensions of dosage (quantity, duration, and temporal pattern) of two sets of brief and skill-targeted SEL activities (Mindfulness and Brain Games) implemented in 20 primary schools in two low-income chiefdoms of Sierra Leone.ResultsWe find preliminary evidence of predictive validity that these dosage measures could predict children’s attendance and classroom adaptive behavior.DiscussionThis study is the first to develop procedures to measure the dimensions of dosage of brief SEL activities in humanitarian settings. Our findings illuminate the need for future research on optimizing the dosage and implementation design of SEL programming using brief SEL activities.
The neural correlation of emotion recognition ability and depressive symptoms–evidence from the HCP database
Authors: Yuan Ze , Lin Xiao , Li Peng , Gao Yu-Jun , Yuan Kai , Yan Wei , Zhang Yu-Xin , Liu Lin , Zhu Xi-Mei , Zhang Yi-Jing , Bao Yan-Ping , Chang Su-Hua , Lu Lin , Shi Le 
Published: January 2023

IntroductionNegative bias of emotional face is the core feature of depression, but its underlying neurobiological mechanism is still unclear. The neuroimaging findings of negative emotional recognition and depressive symptoms are inconsistent.MethodsThe neural association between depressive symptoms and negative emotional bias were analyzed by measuring the associations between resting state functional connectivity (FC), brain structures, negative emotional bias, and depressive problems. Then, we performed a mediation analysis to assess the potential overlapping neuroimaging mechanisms.ResultsWe found a negative correlation between depressive symptoms and emotional recognition. Secondly, the structure and function of the inferior and lateral orbitofrontal gyrus are related to depressive symptoms and emotional recognition. Thirdly, the thickness of the inferior orbitofrontal cortex and the FC between the inferior orbitofrontal gyrus and fusiform gyrus, precuneate and cingulate gyrus mediated and even predicted the interaction between emotion recognition and depressive symptoms. Finally, in response to a negative stimulus, the activation of the frontal pole and precuneus lobe associated with the inferior orbitofrontal gyrus was higher in participants with depressive symptoms.ConclusionThe core brain regions centered on the inferior orbitofrontal cortex such as middle temporal gyrus, precuneus lobe, frontal pole, insula and cingulate gyrus are the potential neuroimaging basis for the interaction between depressive symptoms and emotional recognition.
Assessment of type 2 diabetes mellitus patients' behavioral characteristics associated with integrated treatment and prevention services in community health centers in China
Authors: Zhao Ran , Zhao Nan , Wang Sizhe , Zhang Xia , Ding Bogui , Li Ying , Miao Wenxue , Pan Lihua , Fan Hong 
Published: January 2023

ObjectiveThe purpose of this study was to describe behavioral characteristics of type 2 diabetes mellitus (T2DM) patients, identify homogeneous clusters, and explore factors affecting behaviors associated with integrated treatment and prevention (ITP) services for T2DM in community health centers in China.MethodsA convenient sampling method was employed at a community health center between January and July 2022 in Nanjing. A total of 354 patients completed the self-reported questionnaires. After performing a Cluster Analysis to create a profile of participants' behaviors, a multiple linear regression analysis was conducted to explore the correlations between T2DM patients' characteristics and their behaviors associated with ITP services.Results316 T2DM patients with a mean age of 72.09 years (SD = 5.96) were included. The behavior profiles of patients associated with ITP services were clustered into “Lower” (n = 198) and “Higher” (n = 118) groups, with average scores of 54.41 and 71.46, respectively. Of all the behaviors, complication examination and public health utilization scored the lowest. Health insurance, duration of disease, and treatment modality were independent predictors on the patients' behaviors associated with ITP services for T2DM.ConclusionPatients' behaviors associated with ITP services for T2DM were moderately good (the score rate was 63.98%). Of all the behaviors, complication examination and public health service utilization scored the lowest and, as such, may warrant further research. The clustering of patients' behaviors tends to be polarization, distributed at the upper and lower ends of the behavior spectrum. It is necessary to develop and implement targeted interventions for different groups to improve T2DM patients' behaviors associated with ITP services.
Descriptive and predictive analysis identify centenarians' characteristics from the Basque population
Authors: Cruces-Salguero Sara , Larrañaga Igor , Mar Javier , Matheu Ander 
Published: January 2023

BackgroundCentenarians exhibit extreme longevity and have been postulated, by some researchers, as a model for healthy aging. The identification of the characteristics of centenarians might be useful to understand the process of human aging.MethodsIn this retrospective study, we took advantage of demographic, clinical, biological, and functional data of deceased individuals between 2014 and 2020 in Guipúzcoa (Basque Country, Spain) taken from the Basque Health Service electronic health records data lake. Fifty characteristics derived from demographic, clinical, pharmaceutical, biological, and functional data were studied in the descriptive analysis and compared through differences in means tests. Twenty-seven of them were used to build machine learning models in the predictive analysis and their relevance for classifying centenarians was assessed.ResultsMost centenarians were women and lived in nursing homes. Importantly, they developed fewer diseases, took fewer drugs, and required fewer medical attendances. They also showed better biological profiles, exhibiting lower levels of glucose, hemoglobin, glycosylated hemoglobin, and triglycerides in blood analysis compared with non-centenarians. In addition, machine learning analyses revealed the main characteristics of the profiles associated with centenarians' status as being women, having fewer consultations, having fewer diagnoses of neoplasms, and having lower levels of hemoglobin.ConclusionsOur results revealed the main characteristics linked to centenarians in the Basque Country using Computational Biology programs. These results expand the knowledge on the characterization of the centenarian population and hence of human longevity.
Accelerometer-derived physical activity and sedentary behaviors in individuals with newly diagnosed type 2 diabetes: A cross-sectional study from the Danish nationwide DD2 cohort
Authors: Domazet Sidsel L. , Tarp Jakob , Thomsen Reimar W. , Højlund Kurt , Stidsen Jacob V. , Brønd Jan C. , Grøntved Anders , Nielsen Jens Steen 
Published: January 2023

IntroductionHabitual physical activity behaviors of individuals with new-onset type 2 diabetes are largely unknown. We aimed to investigate accelerometer-derived physical activity behaviors in individuals with newly diagnosed type 2 diabetes. We also examined sociodemographic and health-related correlates of a high-risk physical activity profile.MethodsThis cross-sectional study used data from 768 participants enrolled in an intervention study nested within the Danish Centre for Strategic Research in Type 2 diabetes (DD2) cohort. Physical activity was assessed by 24-h dual monitor accelerometry. Prevalence ratios of having a high-risk physical activity profile were estimated using Poisson regression adjusted for age and sex.ResultsStudy participants spent on average 9.7 (25th and 75th percentiles, 8.3; 11.1) hours/day sitting, walked for 1.1 (0.8; 1.6) hours/day and accumulated 4,000 (2,521; 5,864) steps/day. Still, 62% met the recommendations for physical activity. Characteristics associated with a high-risk physical activity profile (observed in 24.5% of participants) included older age, higher body mass index (BMI), unemployment, retirement, comorbidities, and current smoking. Hence, participants aged 60–69, 70–79 and 80+ years had prevalence ratios of 2.12 (95% CI 1.31; 3.42), 1.99 (1.18; 3.34) and 3.09 (1.42; 6.75) for a high-risk activity profile, respectively, versus participants &lt;50 years. BMI values of 30–39 and 40+ were associated with 1.83 (1.06; 3.15) and 3.38 (1.88; 6.05) higher prevalence ratios compared to normal-weight. Unemployment or retirement was associated with 1.62 (1.09; 2.41) and 2.15 (1.37; 3.39) times higher prevalence ratios, compared to individuals in the working force. Having a Charlson Comorbidity Index score of 1–2 or 3+ was associated with 1.36 (1.03–1.79) and 1.90 (1.27–1.84) higher prevalence ratios, while current smoking was associated with a prevalence ratio of 1.72 (1.25; 2.35) compared to never smokers.ConclusionThis study shows that 62% of individuals with newly diagnosed type 2 diabetes met the recommendations for physical activity. Still, the majority of participants were also highly sedentary and accumulated very few daily steps, emphasizing the need for focusing on both increasing physical activity and reducing sedentary behaviors in the prevention of diabetes-related complications. Individuals with a high-risk physical activity profile were characterized by more obesity, socioeconomic inequalities, advanced age and comorbidities.Trial registration number: NCT02015130.
Introgression of Seedling Plant Resistance to Leaf Rust from Agropyron cristatum into Wheat by Induced Homoeologous Recombination
Authors: Cabrera Adoración , Porras Rafael , Palomino Carmen , Sillero Josefina Carmen 
Published: January 2023

Agropyron cristatum (P genome) is a Triticeae species from the wheat tertiary gene pool which has economic importance as forage and also displays traits beneficial to wheat. Resistance to leaf rust was previously mapped to the short arm of chromosome 1P (1PS) in A. cristatum by the development of a compensating Robertsonian translocation involving chromosome arm 1PS and the long arm of wheat chromosome 1B (1BL). In this study, chromosome arm 1PS was engineered using the ph1b mutation to induce 1BS/1PS homoeologous recombination and to obtain new translocations with shortened fragments of chromosome arm 1PS. Two translocations with different alien fragment sizes were identified by genomic in situ hybridization, wheat 1BS- and 1PS-specific molecular markers and gene-specific markers for glutenin, Glu-B3 and gliadin Gli-B1 seed storage protein. One translocation (called type 1) replaces a proximal segment of 1PS chromatin, and the other (called type 2) replaces a distal 1PS segment and introduces the Glu-B3 and Gli-B1 wheat storage protein loci. Six specific EST-STS markers for chromosome arm 1PS amplified PCR products in the recombinant type 2 translocation line. Resistance analysis showed that the type 2 translocation was highly resistant to a virulent race of leaf rust pathogen. The new wheat–A. cristatum translocations obtained yield material with seedling plant resistance to leaf rust and seed storage protein loci.
Travail, genre et relations de pouvoir dans le Carajas
Authors: Castro Edna Maria Ramos de 
Published: January 2023

Work, gender and power relationship in Carajas.
This paper highlights the links between social changes and the sexual division of labour in the Brazilian case, the area of large industrial zones projects in the Amazone.
Consequences of these rapid and intense transformations in the way of life are put into perspective as well as the processes of women's entry in industry, changes in the labour market and in gender relations at work. In the same way, corporate strategies in the management of the labour force through gender are analysed in parallel with production management. The author demonstrates how the latest methods of sub-contracting are developped without weakening a paternalistic type of management.
Finally, social conflicts in Amazone are developing through social movements and changes in the political scene are analysed in relation to development of political counciousness related to changes in the way of life.
Femmes, citoyenneté et politique dans les années 1920 et 1930 au Québec
Authors: Cohen Yolande 
Published: January 2023

Women, citizenship and policies in Québec in the 1920's and 1930's.
This text presents a historical overview of the rich life of feminine associative network in order to explain the context in which Canadian women obtained the right to vote in the 1920's. The author argues that in this feminine movement is practised the enlargement of social action, mainly in Québec, where women were still excluded from the right to vote until 1940.
They were therefore developing alternative modes of intervention, which analysts did not readily defined as political but social, but which eventually evolved into social policies adopted by the Welfare State. Through the presentation of the Québec case, the author underlines the close relationships that existed between those women associations in articulating a strategy, often ambivalent, to enlarge women pratice of citizenship.
Choisir une carrière, faire carrière : les femmes médecins en France et en Grande-Bretagne
Authors: Crompton Rosemary , Le Feuvre Nicky 
Published: January 2023

Rosemary Crompton, Nicky Le Feuvre : Choose a career, have a career : women doctors in France and Britain.
This article proposes to analyse the process of the development of gendered segregation in a comparative perspective. A comparative study of the professional and family careers of women doctors in France and Britain makes it possible to show that, although at first sight the distribution of women and men in the medical profession seems rather different, the processes of gendered allocation between the different positions within the profession is generally the same in the two countries. The results of this research lead us to think that the gendered structure of the medical profession has been changed relatively little by the recent increase in the rate of féminisation. These conclusion leads us to situate our work within the framework of the recent sociological discussion of the theoretical analysis of the process of reproduction of the sexual division of labour and the gendered segregation of employment in Europe.
Les techniques domestiques ou Cendrillon et les ingénieurs
Authors: Cockburn Cynthia 
Published: January 2023

Cynthia Cockburn : Domestic technologies : Cinderella and the engineers.
Domestic technologies are seldom accorded their true significance either by engineers or sociologists, partly due to an undervaluing of the feminine and the private sphere. Drawing on recent feminist research the article examines the failure of designers and manufacturers to understand and respond to user needs. It shows how in neither Eastern nor Western Europe has domestic equipment been designed thoughtfully within appropriate technological systems, as a sensitive interface between household, community and environment. The sociology of technology too is shown to have neglected the technologies of everyday life, rather than seeing them as the logical starting point of a technology policy.
L'industriel et le domestique dans la conception d'appareils électroménagers
Authors: Chabaud-Rychter Danielle 
Published: January 2023

Danielle Chabaud-Rychter ; Industrial and domestic aspects in the conception of domestic appliances.
In the conception of technical objects for domestic use there exists a dichotomy between the “surface” - including the control panels, the accessories, the instructions - which is for the use of the consumer - and the “interior” where everything which enables the machine to function -motorisation, mechanism, electronic controls - is closed to their access.
This type of conception can be considered as a “detechnicalisation” of machines destined for domestic use and we can wonder, as do the feminists working on the question of the social construction of techniques, if this is in fact a gendering of technical objects intended for use by women. Through daily observation of a research and development team for small domestic appliances, I have tried to understand exactly what they do when they introduce this dichotomy into technical objects : how do they establish the boundary between the interior and the exterior, decide what should be hidden from the consumer, to what she should have access, and how and at what point they consider the sex of the consumer.