bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACETYLCHOLINESTERASE INHIBITION, NOOTROPIC AND ANTIOXIDANT EFFECT OF EXTRACTS FROM AGAVE SPECIES
Authors: Maribel Herrera-Ruiz , Enrique Jiménez-Ferrer , Alejandro Zamilpa , Ruperto Jiménez-Aparicio Antonio , Lucía Arenas-Ocampo Martha , Nayeli Monterrosas-Brisson 
Published: September 2023

Background: The systemic administration of Lipopolysaccharide (LPS) is a pharmacological model to evaluate different processes associated with neurodegeneration; it is capable of causing an increase in the oxidative state in the brain and increasing the activity of the enzyme acetylcholinesterase (ACh-E), involved in the degradation of acetylcholine (ACh). This cholinergic transmission system participates in memory processes, a crucial symptom in neurodegenerative disorders, and its modulation with scopolamine turns out to be an essential tool in the evaluation of plants. Species of the genus Agave are considered a natural resource of economic and cultural importance in Mexico. They possess compounds with anti-inflammatory, antioxidant, and anti-neuroinflammatory activities.
Methods: Extracts of A. tequilana (At-A), A. angustifolia (Aan-A), A. americana (Aam-A) at 125 mg/kg were administered to male ICR mice with LPS to evaluate the ACh-E inhibition, the concentration of the antioxidant enzyme Gluthatione Reductase (GR) and the prooxidant enzyme NADPH Oxidase (NOX). Also, the nootropic effect of these extracts on scopolamine-induced cognitive impairment was evaluated.
Results: The three Agave species studied decreased the ACh-E enzyme activity, Vmax value, and KM. These products increased the GR concentration from 0.173±0.003 (vehicle) to 0.642±0.002 µMol/mg in At-A, which was the highest one. Regarding NOX, only the A. tequilana extract decreased it (0.513±0.002µMol/mg)compared with Vehicle (0.621±0.008µMol/mg). A. tequilana and A. americana species significantly improved the retention latency parameter (260 seconds) during the passive avoidance test.
Conclusion: Agave species showed promising results in developing novel drugs for neurodegenerative disease therapy.

Peer Review History:
Received: 17 June 2023; Revised: 22 July; Accepted: 27 August, Available online: 15 September 2023
Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Received file: Reviewer's Comments:
Average Peer review marks at initial stage: 5.5/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
Prof. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, alialkaf21@gmail.com
Analisis Kepuasan Tamu Terhadap Kualitas Pelayanan Karyawan Kantor Depan
Authors: Putra Putu Arya Krisna Adi , Ismail Deden , Suwintari I Gusti Ayu Eka 
Published: September 2023

The Ritz – Carlton Bali merupakan salah satu hotel bintang 5 yang terletak di Sawangan Nusa Dua , Badung, Bali. Terdapat 2 masalah yang ditemukan di penelitian ini yaitu bagaimana kualitas pelayanan kantor depan terhadap kepuasan tamu dan upaya – upaya yang dilakukan untuk meningkatkan kualitas pelayanan. Penelitian ini juga ditunjukkan untuk menganalisis kepuasaan tamu terhadap pelayanan karyawan kantor depan. Jenis data yang digunakan adalah data kuantitatif. Sumber data pada penelitian ini menggunakan data primer dan sekunder. Semua data tersebut dikumpulkan dengan metode kuesioner yang diberikan langsung kepada tamu. Kemudian data tersebut diukur dengan metode Servqual menurut Supranto (2011). Dalam penelitian ini yang data dianalisis menggunakan teknik analisis uji reliabilitas, uji validitas, dan Diagram Kartesius. Berdasarkan hasil penelitian kepuasan tamu yang diperoleh dari rata-rata kinerja pada angka 0,02 dimana nilainya lebih besar dari 0 menunjukkan kepuasan tamu sangat tinggi. Berdasarkan pembahasan tersebut dapat disimpulkan bahwa tingkat kepuasan tamu sangat tinggi yang didasarkan pada pelayanan yang diberikan oleh karyawan , namun masih ditemukan beberapa indikator tamu merasa kurang puas dengan pelayanan yang diberikan karyawan , hal ini karena karyawan kantor depan belum maksimal dalam memberikan pelayanan terhadap apa yang tamu anggap sangat penting. Dengan hal tersebut maka pihak hotel melakukan beberapa upaya sebagai dasar untuk meningkatkan kualitas pelayanan tamu pada kantor depan Hotel The Ritz -Carlton Bali.

The Ritz – Carlton Bali is a 5 star hotel located in Sawangan Nusa Dua, Badung, Bali. There are 2 problems found in this study, namely how the quality of front office services to guest satisfaction a nd the efforts made to improve service quality. This study was also shown to analyze guest satisfaction with the service of front office employees. The type of data used is quantitative data. Sources of data in this study using primary and secondary data. All of the data was collected by using a questionnaire method which was given directly to the guests. Then the data was measured by the Servqual method according to Supranto (2011). In this study, the data were analyzed using reliability test analysis techniques, validity tests, and Cartesian diagrams. Based on the results of guest satisfaction research obtained from the average performance at 0.02 where the value is greater than 0 indicates very high guest satisfaction. Based on the discussion, it can be concluded that the level of guest satisfaction is very high based on the services provided by employees, but there are still some indicators that guests feel dissatisfied with the services provided by employees, this is because the front office employees have not been maximal in providing services to what guests consider very important. With this, the hotel made several efforts as a basis for improving the quality of guest service at the front office of The Ritz-Carlton Bali Hotel.
Kualitas Abon Vegetarian Berbahan Dasar Bonggol Pisang Klutuk
Authors: Dewi Ida Ayu Ari Chandra , Lestari Denok 
Published: September 2023

Abon merupakan makanan yang tidak asing lagi dikonsumsi oleh masyarakat Indonesia. Tujuan dari penelitian ini adalah untuk mengetahui kualitas abon vegetarian berbahan dasar bonggol pisang klutuk melalui eksperimen uji organoleptik dari segi rasa, warna, tekstur dan aroma, kemudian untuk mengetahui daya tahan , minat konsumen serta untuk mengetahui biaya produksi dari produk abon vegetarian berbahan dasar bonggol pisang klutuk. Adapun metode penelitian yang digunakan pada penelitian ini adalah metode penelitian eksperimen dengan teknik pengumpulan data menggunakan kuantitatif dan kualitatif. Hasil dari penelitian ini berdasarkan uji organoleptik yang dilakukan oleh 20 panelis memperoleh hasil enak dari segi rasa, menarik dari segi warna, kering dari segi tekstur dan sangat harum dari segi aroma. Dari uji daya tahan abon vegetarian berbahan dasar bonggol pisang klutuk, mampu bertahan selama 7 hari. Hasil survey minat konsumen menunjukkan masyarakat tertarik dengan inovasi produk abon ini. Hasil analisis biaya satu kali produksi abon adalah Rp 32.575,- serta biaya untuk satuan produk dengan berat 100 gram/ bungkus adalah Rp 16.300.

Abon or Floss is a food that is familiar consumed by the people of Indonesia. The purpose of this study was to determine the quality of vegetarian floss klutuk banana hump through organoleptic testing in terms of taste, color, texture and aroma, then to determine durability, consumer interest and to determine the production cost of vegetarian floss made of klutuk banana hump. The research method used in this study is an experimental research method with data collection techniques using quantitative and qualitative. The results of this study based on organoleptic tests conducted by 20 panellists obtained good results in terms of taste, attractive in terms of colour, dry in terms of texture and very fragrant in terms of scent. From the resistance test the vegetarian floss klutuk banana hump was able to last for 7 days. The results of the consumer interest survey show that people are interested in this floss product innovation. The result of the one-time cost analysis is Rp 32.575, - and the unit price with a weight of 100 grams/pack is Rp 16,300.
Pengaruh Penggunaan Puree Labu Kuning Terhadap Kualitas Kulit Dimsum
Authors: Friets Hans , Wardana Miko Andi 
Published: September 2023

Dimsum adalah kudapan yang terbuat dari tepung terigu dan tepung kentang yang menjadi bahan utama dalam pembuatan kulit dan isian yang biasanya menggunakan paha ayam ataupun udang, proses pembuatan dimsum sama saja pada dasarnya sehingga yang membedakan hanya isian yang terdapat dalam dimsum itu sendiri.dalam mengatasi persamaan pada kualitas dimsum ini diperlukan alternatif lain seperti mengganti bahan atau mencampur bahan baku dengan bahan lain, Daging labu kuning mempunyai nilai gizi yang tinggi, sehingga dapat digunakan sebagai bahan tambahan dalam membuat suatu produk makanan. Tujuan yang dicapai pada penelitian ini adalah apakah daging labu kuning dapat dijadikan alternatif sebagai bahan campuran dengan tepung terigu, tepung maizena,tepung tapioka dan tepung kentang dalam pembuatan kulit dimsum. Hasil penelitian adalah (P0) dengan menggunakan 25% Daging labu kuning yang paling banyak disukai oleh panelis diperoleh dari skor yang berasal dari perhitungan kuesioner yang telah dibagikan yang ditinjau dari aspek: Warna, Aroma, Tekstur, Rasa.

Dimsum is a snack made from wheat flour and potato flour which are the main ingredients in making the Wrapper and the filling which usually uses chicken or shrimp thighs, the process of making dimsum is basically the same so that the only difference is the stuffing inside. dimsum itself. This dimsum quality equation requires other alternatives such as replacing ingredients or mixing raw materials with other ingredients. Pumpkin meat has a high nutritional value, so it can be used as an additional ingredient in the manufacture of a food product. This study aims to determine whether pumpkin flesh can be used as an alternative to a mixture of wheat flour, cornstarch, tapioca flour and potato flour in the manufacture of dimsum Wrapper. The results of the study were (P0) using 25% pumpkin flesh which was the most preferred by the panelists, obtained from the scores obtained from the calculation of the questionnaire that had been distributed in terms of aspects: Color, Aroma, Texture, Taste.
Kualitas Sari Jahe Sebagai Bahan Pembuatan Puding
Authors: Wijaya Pande Made Krisna Angga , Mariani Ni Wayan Rena 
Published: September 2023

Puding merupakan hidangan penutup yang banyak digemari orang dimana hidangan ini memiliki tekstur kenyal dan rasa yang manis. Puding pada umumnya terbuat dari susu dan bahan pengental seperti gelatin, bubuk agar- agar, kuning telur serta bahan lainnya. Tujuan dari penelitian ini adalah untuk mengetahui kualitas puding dengan penambahan sari jahe yang dinilai dari segi warna, aroma, rasa dan tekstur. Jahe merupakan salah satu tanaman rempah yang memiliki khasiat yang baik bagi kesehatan tubuh karena menjadi salah satu rempah yang memiliki kandungan antioksidan. Selain itu jahe juga memiliki minyak atsiri yang berkhasiat untuk mencegah dan mengobati berbagai penyakit. Jenis penelitian ini adalah penelitian eksperimen, dengan sumber data yang digunakan adalah data primer dan data sekunder. Metode pengumpulan data yang dilakukan adalah dengan mekanisme kuisioner dan observasi. Hasil dari penelitian yang sudah dilakukan menunjukan bahwa puding jahe memiliki warna yang Menarik, aroma yang Kuat, Rasa yang Enak serta tekstur yang Lembut. Dan daya tahan puding jahe yang disimpan pada lemari pendingin bertahan selama 1 minggu.

Pudding is a dessert that many people like where this dish has a chewy texture and a sweet taste. Puddings are generally made from milk and thickening agents such as gelatin, gelatin powder, egg yolks and other ingredients. The purpose of this study was to determine the quality of pudding with the addition of ginger juice which was assessed in terms of color, aroma, taste and texture. Ginger is one of the spice plants that has good properties for the health of the body because it is one of the spices that contains antioxidants. In addition, ginger also has essential oils that are efficacious to prevent and treat various diseases. This type of research is experimental research, with the data sources used are primary data and secondary data. The data collection method used is a questionnaire and observation mechanism. The results of the research that has been done show that ginger pudding has an attractive color, strong aroma, delicious taste and soft texture. And the durability of the ginger pudding stored in the refrigerator lasts for 1 week.
Bacterial isolates and their antimicrobial susceptibility profile of superficial and deep-seated skin and soft tissue infections
Authors: Abid Khan Rao Muhammad , Dodani Sunil Kumar , Nadeem Ali , Jamil Sana , Zafar Mirza Naqi 
Published: September 2023

Abstract

Background
Skin and soft tissue infections (SSTIs) are caused by microbial invasion of healthy or damaged skin. SSTIs are difficult to manage and contribute to chronicity and emergence of antimicrobial resistance.

Objectives
To ascertain the prevalence of bacteria causing SSTIs and their antimicrobial susceptibility patterns.

Methods
A prospective study between November 2020 and May 2021. A total of 447 samples from SSTIs were analyzed.

Results
A total of 347 samples revealed mono-bacterial growth, of which 67% were male. SSTIs are common among patients aged 21–50 years with the dominance (78%) of gram-negative rods (GNRs). Escherichia coli (36%), Klebsiella spp. (22%), Staphylococcus aureus (16%), and Pseudomonas aeruginosa (11%) were predominant organisms. GNRs were highly resistant (>65%) to ciprofloxacin and trimethoprim–sulfamethoxazole. For injectable antibiotics, the highest resistance was determined against ceftriaxone, and the least resistance was determined against amikacin. Resistance against carbapenem was the highest among P. aeruginosa (53%) and Klebsiella spp. (32%). S. aureus showed the highest resistance against ciprofloxacin, and the least resistance was determined against clindamycin. Of 57 S. aureus isolates, 86% isolates were methicillin-resistant Staphylococcus aureus (MRSA). All isolates of P. aeruginosa and S. aureus were sensitive to polymyxin B and vancomycin, respectively. The prevalence of multidrug-resistant E. coli and Klebsiella spp. was higher among deep-seated SSTIs (dSSTIs).

Conclusions
The predominant etiology of SSTIs is GNR. Currently, there is very high resistance against oral antibiotics. Antimicrobial resistance against carbapenem has also increased. Moreover, there is a high frequency of MRSA. MDR E. coli and Klebsiella spp. isolates are frequently involved in dSSTIs.
Copy number variations of cytochrome P450 genes in Kinh Vietnamese
Authors: Vu Nhung Phuong , Nguyen Ton Dang , Nguyen Binh Huy , Nguyen Duong Thuy , Nong Hai Van , Nguyen Ha Hai 
Published: September 2023

Abstract

Background
The cytochrome P450 (CYP450) family is well known as a major group of drug metabolizing enzymes. The polymorphism of CYP450 genes is the main factor having an impact on the interindividual difference in drug response, including drug efficacy and drug safety. The single nucleotide polymorphism (SNPs) of Vietnamese Kinh has been widely studied, but information about the copy number variations (CNVs) of other CYP450 genes is still unknown.

Objective
To identify the CNV variability of CYP450 in 154 healthy unrelated Kinh Vietnamese, except eCYP2D6, which was previously reported.

Methods
Multiplex Ligation-Dependent Probe Amplification (MLPA) was applied for determination of copy number of 10 CYP450 genes. Later, PCR or quantitative PCR (qPCR) was used to confirm the detected CNVs in randomly chosen subjects.

Results
Of the 154 subjects, along with CYP2D6, 4 other CYP450 genes showed CNVs including duplications (CYP1B1), deletions (CYP2A6 and CYP2C9), and both duplications and deletions (CYP2E1). Among these, CYP2A6 exhibited the greatest frequency of CNVs compared with other CYP450, in which CYP2A6Del accounted for 11%. Meanwhile, allele CYP2E1Del showed the lowest frequency with only 0.3%.

Conclusions
The present study provides new insight into CYP450 CNVs in the Kinh Vietnamese cohort. Our data have contributed to genetic profiling of CYP450 CNVs in Vietnam, which would be helpful for facilitating implementation of pharmacogenetics in drug dosing adjustment in Vietnam.
The use of traditional Chinese elements in modern interior design in the context of multimedia
Authors: Zhu Zhenji 
Published: September 2023

Abstract
Chinese traditional elements have to carry on their own inheritance and innovation in continuous social development, and this process will encounter different challenges and complex problems. In order to better integrate traditional elements into interior design, this paper analyzes the current situation of integrating traditional elements into modern interior design, uses a neural network model to explore the influence of multimedia context on the modern interior design of traditional Chinese elements, and investigates modern people’s preference for the way traditional elements are integrated into modern interior design through a questionnaire survey. The results show that the priority factors for choosing an interior design, the number of consumers aged 20-35 who prefer their favorite style in home decoration, accounts for about 40% of the total, and the cross analysis shows that the sense of atmosphere accounts for 15%, which shows that young people around 20-35 years old have the personality of the times and pursue a high quality of life. Only the age older users will consider comfort. It can be seen that interior design with traditional elements is more in line with the preferences of older people. Inheritance and innovation of traditional Chinese culture is a huge challenge, and the reasonable integration of traditional and modern science needs to make attempted more.
Analysis of the impact of college students’ innovation and entrepreneurship on human resource index of science and technology enterprises based on logistic regression model
Authors: Wang Jia , Li Li 
Published: September 2023

Abstract
Considering the immediate phenomenon of uncoordinated advancement, unbalanced distribution and unreasonable structure of regional human resources and academy undergraduates’ innovation and start an undertaking ability in China, this paper fundamentally constructs academy undergraduates’ innovation and entrepreneurship system through a logistic regression model. The study takes 29 provinces and regions in China as research samples and adopts the logistic regression model BP neural network method to conduct a more in-depth theoretical discussion and empirical analysis on the interaction mechanism and the coupled and coordinated development of regional manpower capital and produce and start an undertaking ability in China. The coupling and coordination degree of manpower capital and production and start an undertaking in 29 provinces and regions in China is lower than 0.8, and the average value is 0.358, which is in the “mild dysfunctional decline” stage. There are some mutual constraints between the subsystems of human resources of science and technology enterprises and the products and start an undertaking ability of academy undergraduates, and more efforts must be made in their respective “shortcomings” and comparative disadvantages to promote the synergy and consistency of their development levels. We should strive to strengthen cooperation with foreign countries and introduce advanced technology and outstanding talents from developed countries. In the “import” at the same time “go out”, in the learning from the same time also “teach others to fish”, in order to achieve win-win cooperation.
Noise Reduction of Cable Partial Discharge Vibration Signal based on EEMD-CIIT method
Authors: Tan Xiao , Zhang Wei , Chen Jie , Li Chenying , Cao Jingying 
Published: September 2023

Abstract
The cable partial discharge vibration signal is often polluted by noise. It is necessary to denoise the signal, improve the signal-to-noise ratio, and then realize the feature extraction of the vibration signal. Therefore, this paper builds a cable partial discharge test platform, collects the time-domain waveform of vibration signals under different working conditions, analyzes the noise reduction effect of ensemble empirical mode decomposition clearing repetition interval threshold noise reduction method under different threshold functions, and analyzes the difference and approximation degree between the simulated signal and the real signal after noise reduction by using signal-to-noise ratio and correlation, By comparing the difference of statistical characteristics in different defects before and after noise reduction, the wavelet threshold denoising method is established synchronously and compared with the proposed method. The results show that the high-frequency part of the vibration signal has obvious random noise components, and the effective frequency is mainly concentrated in the low-frequency band; The smoothing shear absolute deviation penalty threshold function has the smoothest curve after noise reduction and the highest approximation to the real signal. The high-frequency noise component is eliminated, and the low-frequency band frequency component is effectively retained. The method proposed in this paper can be extended to the noise reduction of vibration signals of other industrial equipment and provide technical support for the signal noise reduction of various industrial equipment.
Deep learning-based fault diagnosis and localization method for fiber optic cables in communication networks
Authors: Zhang Lixia , Gao Wei , Yan Leifang 
Published: September 2023

Abstract
With the arrival of the big data era and the development of new network technology, how to use big data technology to diagnose and locate fiber optic cable faults in communication networks has become a hot topic of current concern. Firstly, a combined generative adversarial network and convolutional neural network algorithm is proposed based on a deep learning algorithm, then an improved fault diagnosis model combining generative adversarial network and convolutional neural network algorithm is built, and finally, the combined generative adversarial network and convolutional neural network model is used to verify and analyze the fiber optic cable fault diagnosis. The results show that the accuracy of the DCGAN-CNN algorithm for fiber optic cable fault diagnosis is 98.5%, and the research results verify the effectiveness of the combined generative adversarial network and convolutional neural network model for fiber optic cable fault diagnosis. This study can accurately and comprehensively solve the problem of fiber optic cable faults in communication networks and thus play a guiding reference value for developing fault diagnosis in Chinese communication networks.