bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sargassum vulgare extract as a bio‐elicitor of natural stilbenes production and antioxidant potential in peanut (Arachis hypogaea L.) sprouts
Authors: Ghozlen Hajer Ben , Werbrouck Stefaan P.O. , Mangelinckx Sven 
Published: January 2023

SummaryTrans‐resveratrol is a natural polyphenolic compound, belonging to the class of stilbenes. It is known for its various pharmacological properties but limited bioavailability. Our objective was to evaluate for the first time the effect of an extract of Sargassum vulgare on resveratrol, piceatannol and piceid production in peanut (Arachis hypogaea) sprouts. Treatments with rising concentrations of seaweed extract were assessed in ‘Trabelsia’, ‘Chanfakhi’ and ‘American’ peanut varieties after 7 days of incubation. Liquid chromatography‐mass spectrometry was performed to quantify targeted compounds. Total phenols and flavonoids content, PAL and TAL activity and DPPH radical scavenging activity were also determined. A significant genotype effect was demonstrated, as quite exceptionally, in ‘Trabelsia’ the resveratrol content was increased by a factor 110 by elicitation with 8% extract. Piceatannol, piceid, TPC, TFC, PAL, TAL, and DPPH radical scavenging activity confirmed the same trend. This study provides a new insight into an effective approach to enable the accumulation of resveratrol and its derivatives in peanut sprouts for use as a functional food.
Physicochemical and digestive properties of Lipu taro (Colocasia esculenta (L.) Schott) flour and starch
Authors: Tu Lian , Nisar Tanzeela , Lv Chun‐Qiu , Yang Zhang‐Feng , Fang Zhongxiang , Wang Zi‐Chao , Lin Ying 
Published: January 2023

SummaryLipu taro (Colocasia esculenta (L.) Schott) is a popular tuber crop in China. This study investigated the physicochemical and digestive properties of Lipu taro flour (LTF) and Lipu taro starch (LTS). The results showed that LTF was composed of LTS (79.13%) and non‐starch substances including protein (7.71%), lipid (0.32%), dietary fibre (2.13%), ash (1.05%) and moisture (9.17%). LTF had higher content of enzyme‐resistant starch (ERS, 36.52%) and the anon‐starch substances of protein and dietary fibre can inhibit the activity of digestive enzymes, which led to that LTF had a lower digestive degree during the in vitro gastrointestinal digestion than that of LTS. Moreover, LTS shared similar nutritional compositions including total starch (about 88%) and moisture (about 11%) to the commercial starches including rice, corn and wheat starches (RS, CS and WS, respectively). However, LTS showed the smallest particle size (0.485–7.211 μm) which conferred it the smallest DPn value (16725) compared with other high‐rapidly digestible starches (RDS) of RS and CS. The physical characteristics might have prevented the bonding of LTS to the digestive enzymes, leading to its lower digestive degree than that of RS and CS, and was comparable to the low‐RDS starch of WS. The results suggested that the consumption of LTF and LTS may not induce high glucose levels in human, suggesting Lipu taro is a healthy food.
How migration information campaigns shape local perceptions and discourses of migration in Harar city, Ethiopia
Authors: Pagogna Raffaella , Sakdapolrak Patrick 
Published: January 2023

AbstractMigration‐information campaigns informing potential migrants about the risks of the journey and the harsh life conditions in the destination countries have emerged as prominent tools of migration management in the last decades. Despite their growing importance, little is known about their local implementation in countries of transit and origin as well as their influence on potential migrants' perceptions and experiences. The central objective of this paper is to understand how migration‐information campaigns are implemented on a local scale and how they shape the perception and discourses of migration in the region. We pursue a multi‐scalar analysis of international migration management policies and their outcomes in a specific place and link them with local migration aspirations. The paper is based on qualitative empirical research carried out in Harar, a medium‐sized city in the Harari regional state of Ethiopia. Drawing on interviews with government officials, NGOs, city dwellers, and return migrants, as well as the analysis of policy documents and scientific literature, we show how the local implementation of migration‐information campaigns shapes the local perceptions and discourses on migration within which migration aspirations are embedded. We found that information campaigns did not take into account the complexity and multifaceted nature of local socioeconomic and political conditions which reflects the discrepancy between policy discourses at large and people's perceptions.
Befriended to polarise? The impact of friend identity on review polarisation—A quasi‐experiment
Authors: Wang Lin , Wang Chong (Alex) , Yao Xinyan 
Published: January 2023

AbstractOpinion polarisation in social media has recently become a significant issue. The existing literature mainly attributes polarisation to online friends' informational social influence, that is, users are more likely to interact with others with similar opinions, which leads to the echo chamber effect. However, the impact of social interaction on individual polarisation may also result from normative social influence, which varies with social settings on the platform. In this paper, we leverage a quasi‐experiment to investigate the normative social influence of online friends on focal users' review polarity. We use fixed effects and difference‐in‐differences approaches, along with propensity score matching, to address the potential endogeneity in users' friend function adoption decisions. Our results indicate that adopting the friend function leads users to post less extreme ratings. We further separate the reviews into positive and negative, finding that the reduction in the review polarity for positive reviews is more prominent than for negative ones. Regarding user heterogeneity, our causal forest analysis uncovers that users with a higher engagement level on the platform are less affected by adopting the friend function than those with less engagement. Our study has clear implications for managers and platform designers, highlighting the importance of social function design in reducing social media induced polarisation.
Optimizing wind farm cable layout considering ditch sharing
Authors: Cerveira Adelaide , de Sousa Amaro , Pires E. J. Solteiro , Baptista José 
Published: January 2023

AbstractWind power is becoming an important source of electrical energy production. In an onshore wind farm (WF), the electrical energy is collected at a substation from different wind turbines through electrical cables deployed over ground ditches. This work considers the WF layout design assuming that the substation location and all wind turbine locations are given, and a set of electrical cable types is available. The WF layout problem, taking into account its lifetime and technical constraints, involves selecting the cables to interconnect all wind turbines to the substation and the supporting ditches to minimize the initial investment cost plus the cost of the electrical energy that is lost on the cables over the lifetime of the WF. It is assumed that each ditch can deploy multiple cables, turning this problem into a more complex variant of previously addressed WF layout problems. This variant turns the problem best fitting to the real case and leads to substantial gains in the total cost of the solutions. The problem is defined as an integer linear programming model, which is then strengthened with different sets of valid inequalities. The models are tested with four WFs with up to 115 wind turbines. The computational experiments show that the optimal solutions can be computed with the proposed models for almost all cases. The largest WF was not solved to optimality, but the final relative gaps are small.
Indicators of health in Down syndrome: A virtual focus group study with patients and their parents
Authors: Santoro Stephanie L. , Cabrera Maria J. , Haugen Kelsey , Krell Kavita , Merker Vanessa L. 
Published: January 2023

AbstractBackgroundDown syndrome has a unique medical and psychological profile. To date, few studies have asked individuals with Down syndrome about their views of health.MethodsEight focus groups of 20 parents and 8 individuals with Down syndrome, were conducted virtually via videoconferencing to obtain participants' views of health indicators. Focus group moderators employed some modifications for individuals with Down syndrome, including simplified language and use of graphics. Transcripts were coded using a hybrid inductive/deductive framework and thematically analysed using the Framework Method.ResultsWe describe lessons learned in conducting virtual focus groups of individuals with Down syndrome and their parents. Individuals with Down syndrome could describe their views of health indicators and identified many of the same topics as their parents. Both groups discussed physical, mental, and social health components. However, people with Down syndrome gave a more restricted range of examples, but with different nuances than parents.ConclusionParticipants discussed physical, social, and mental well‐being components of health in Down syndrome. Interviewing individuals with Down syndrome in virtual focus groups with appropriate modifications added important self‐report health information.
Pessimistic assessments of ability in informal conversation
Authors: Welker Christopher , Walker Jesse , Boothby Erica , Gilovich Thomas 
Published: January 2023

AbstractConversation is one of the most common ways of establishing social connection and satisfying the need to belong. But despite spending considerable time talking to others, many people report that engaging in informal conversation with anyone other than close friends and family makes them anxious. In this research, we explored people's assessments of their conversational ability. In Studies 1a–1c, we found that people are relatively pessimistic about their skills in conversation when compared to other common activities. We also provide support for the hypothesis that this pessimism is driven by a tendency to not engage in the usual pattern of self‐serving attributions when it comes to the positive and negative moments of conversations. Instead, people attribute the low points of a conversation more to themselves than to the other person (Studies 2 and 3). We discuss the origins of this attributional pattern, as well as other potential mechanisms underlying conversational pessimism, in the General Discussion.
Epistemic motivation facilitates advice seeking and utilization by groups
Authors: Yoon Young‐Jae , Larson James R. , Tindale R. Scott , Ro Hea‐Kyung 
Published: January 2023

AbstractDrawing on a motivated information processing model, we tested the hypothesis that groups' receptivity to outside advice is facilitated by their epistemic motivation—the desire to gain an accurate understanding of the world. Epistemic motivation was measured by proxy in Study 1 using a team task reflexivity measure, and was experimentally manipulated in Studies 2 and 3 by varying, respectively, either the amount of time allotted to complete the task or whether a consensus judgment was required before receiving advice. Receptivity to advice was operationalized as group advice seeking in Studies 1 and 2, and as advice utilization in Study 3. In support of our hypothesis, groups with higher levels of epistemic motivation consistently sought out and utilized advice more than those with lower levels of epistemic motivation. Moreover, epistemic motivation affected judgment accuracy via groups' receptivity to advice.
Text analytics for uncovering untapped ideas at the intersection of learning design and learning analytics: Critical interpretative synthesis
Authors: Stoyanov Slavi , Kirschner Paul A. 
Published: January 2023

AbstractBackgroundLearning analytics (LA) collects, analyses, and reports data from the learning environment, to provide evidence of the effects of a particular learning design. Learning design (LD) outlines the conceptual framework for a meaningful interpretation of Learning analytics data.ObjectivesThe study aims to identify the most relevant concepts at the intersection of learning design and learning analytics, how these concepts are integrated into more general thematic areas, and the implications for the research and practice of the learning design and learning analytics synergy.MethodsTo this end, the study employs a critical interpretive synthesis (CIS) of the selected papers, and complements it with elements of systematic literature review as well as qualitative content analysis and text analytics that employ machine learning and language technology.Results and conclusionsThe most important themes identified are ‘analytics’, ‘learning’, ‘data’, ‘tools’, ‘research’, ‘framework’, ‘informed’, ‘model‐driven’, ‘participatory’, ‘technique’, ‘impact’, insight’, and ‘findings'. The text analytics detected two topic rarely explicitly discussed in the literature: ‘evidence‐informed instructional design approaches' and ‘design‐based research’. Future research should attempt a holistic perspective towards the LD and LA synergy considering evidence‐informed instructional design approaches as part of a design‐based research methodology that implements evidence‐based teachers' practice and research‐based findings.
Ribosomal protein L22‐like1 promotes prostate cancer progression by activating PI3K/Akt/mTOR signalling pathway
Authors: Yi Xiaoyu , Zhang Chao , Liu Baojie , Gao Guojun , Tang Yaqi , Lu Yongzheng , Pan Zhifang , Wang Guohui , Feng Weiguo 
Published: January 2023

AbstractProstate cancer (PCa) is one of the most common malignancies in men. Ribosomal protein L22‐like1 (RPL22L1), a component of the ribosomal 60 S subunit, is associated with cancer progression, but the role and potential mechanism of RPL22L1 in PCa remain unclear. The aim of this study was to investigate the role of RPL22L1 in PCa progression and the mechanisms involved. Bioinformatics and immunohistochemistry analysis showed that the expression of RPL22L1 was significantly higher in PCa tissues than in normal prostate tissues. The cell function analysis revealed that RPL22L1 significantly promoted the proliferation, migration and invasion of PCa cells. The data of xenograft tumour assay suggested that the low expression of RPL22L1 inhibited the growth and invasion of PCa cells in vivo. Mechanistically, the results of Western blot proved that RPL22L1 activated PI3K/Akt/mTOR pathway in PCa cells. Additionally, LY294002, an inhibitor of PI3K/Akt pathway, was used to block this pathway. The results showed that LY294002 remarkably abrogated the oncogenic effect of RPL22L1 on PCa cell proliferation and invasion. Taken together, our study demonstrated that RPL22L1 is a key gene in PCa progression and promotes PCa cell proliferation and invasion via PI3K/Akt/mTOR pathway, thus potentially providing a new target for PCa therapy.
New‐onset type 1 diabetes and Graves' disease after antiretroviral therapy in a patient with human immunodeficiency virus infection
Authors: Taguchi Maho , Ihana‐Sugiyama Noriko , Shiojiri Daisuke , Izumi Kazuo , Kobayashi Michi , Kodani Noriko , Bouchi Ryotaro , Ohsugi Mitsuru , Tanabe Akiyo , Ueki Kohjiro , Kajio Hiroshi 
Published: January 2023

AbstractPatients with human immunodeficiency virus (HIV) infection receiving antiretroviral therapy can develop autoimmune diseases, referred to as immune‐inflammatory reconstitution syndrome. Nevertheless, only a few reports on the onset of type 1 diabetes as immune‐inflammatory reconstitution syndrome are available. A 40‐year‐old Japanese man with HIV infection was initiated with antiretroviral therapy at the age of 29 years. He developed Graves' disease at 35 years and diabetes, with a hemoglobin A1c of 6.5%, and maintained insulin secretion at 38 years. His antiglutamic acid decarboxylase antibody level was >2,000 U/mL, and he was diagnosed with slowly progressive type 1 diabetes. At the age of 40 years, he was admitted to our hospital with diabetic ketosis. We retrospectively assayed his stored plasma samples for thyroid‐stimulating hormone receptor antibody and antiglutamic acid decarboxylase antibody, which showed positive conversion after initiating antiretroviral therapy, suggesting that Graves' disease and type 1 diabetes developed as a probable result of immune‐inflammatory reconstitution syndrome.
Ultrasound‐assisted extraction of bioactive compounds from giloy (Tinospora cordifolia) stem: Quantitative process optimization and bioactives analysis
Authors: Kumar Nitin , Kumar Gaurav , Prabhakar Pramod K , Sahu Jatindra K , Naik Satyanarayan 
Published: January 2023

AbstractGiloy (Tinospora cordifolia), a medicinal herb, contains several bioactives having immunomodulatory properties and various health benefits. In this study, giloy stem extract was derived using ultrasound process followed by screening of secondary metabolites and bioactives. Box–Behnken design coupled with RSM was employed for the optimization of yield, total phenolic content and antioxidant activity of GSE with respect to solvent‐to‐solid (SS) ratio, sonication time (ST), and ultrasound amplitude (UA). The UA, ST and their interaction effects had significantly influenced the green extract yield and quality. The optimum extractions conditions were found to be 30% (UA), 10:1 (SS ratio), and 30 min (ST). The optimum responses were obtained as follows: extract yield: 9.614 ± 0.015%, TPC: 100.04 ± 0.133 (mg GAE/100 g extract), and DPPH % inhibition: 78.8523 ± 0.399%. Screening of optimized extract through HR‐LCMS‐QTOF reported the presence of major polyphenols such as malic acid, catechin, and quercitrin with a match factor of 99.23%, 98.65%, and 90.58%, respectively.Practical applicationsGiloy (T. cordifolia) is a potential source of bioactive compounds with significant medicinal properties and chemical stability. Recent trends suggest paradigm shift toward research and development of active food from the herbal plant for special purposes such as supplements, functional food, nutraceuticals, or medicine. Thus, non‐thermal extraction and characterization of extract for screening along with higher retention of bioactive from herbal plants such as giloy and its utilization becomes a crucial part of any industry. In this regard, the present study on ultrasound extraction is the way ahead due to high bioactive retention and the cost implications of the process.
Experimental and modeling for catechin and epicatechin recovery from peanut skin using subcritical ethanol
Authors: Putra Nicky Rahmana , Rizkiyah Dwila Nur , Qomariyah Lailatul , Aziz Ahmad Hazim Abdul , Veza Ibham , Yunus Mohd Azizi Che 
Published: January 2023

AbstractA study on the valorization of peanut (Arachis hypogea) skin as agricultural waste to recover bioactive compounds, including catechin and epicatechin, by subcritical ethanol extraction (SEE) is unexplored scientifically. Thus, this study aims to determine the parameter effects on peanut skin extract recovery by SEE, followed by identifying the semi‐empirical modeling. The best conditions were 6 MPa, 4.53 ml/min, 86.23°C with responses of catechin 188.66 μg/g and epicatechin 336.41 μg/g. High pressure and temperature conditions are conducive to catechin recovery, whereas high pressure with low‐temperature conditions is suitable for epicatechin enhancement. Del Valle Aguilera (DVA) fits the solubility of catechin and epicatechin in SEE effectively compared with the Chrastil model since it has the lowest average absolute relative deviation (AARD), which is 5.97% and 12.69%, respectively. As a result, this approach (SEE) may be used in place of the conventional method for extracting catechin and epicatechin for medicinal purposes.Practical ApplicationSubcritical ethanol extraction (SEE) is more uncomplicated and capable of attaining high extraction rates in a relatively short time to extract catechin and epicatechin from peanut skin. This is because subcritical ethanol rather than subcritical water extraction (SWE) is used to extract catechin and epicatechin from peanut skin at temperatures below 110°C. SEE also employs the lower pressure condition (P < 30 MPa) than SFE. Therefore, SEE is more advantageous than SWE owing to its lower operating conditions, allowing less energy usage. Hopefully, this technology (SEE) may replace the usual technique for extracting catechin and epicatechin for therapeutic uses.
Human milk expression in the first year postpartum among persons with low incomes
Authors: Nakayama Jasmine Y. , Marks Kristin J. , McGowan Andrea , Li Ruowei , Hamner Heather C. 
Published: January 2023

AbstractBackgroundExpressing milk (i.e., human milk) is common in the USA, but practices are unknown among families in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC). This study of a WIC population explores the practice of and reasons for expressing milk in the first year postpartum.MethodsWe analysed data from a longitudinal study to examine milk expression at 1, 3, 5, 7, 9, 11, and 13 months postpartum among breastfeeding persons enrolled in WIC with term singletons. We cross‐sectionally analysed the weighted prevalence of milk expression at each survey month and report reasons for milk expression in the first 7 months.ResultsAmong the study participants who reported feeding human milk at Month 1, 70.4% expressed milk in the first 13 months postpartum. The prevalence of milk expression was 56.8% at Month 1 and decreased to 13.9% at Month 13 among those feeding any human milk that month. Reasons for expressing milk changed over time; in the first month, increasing milk supply, relieving engorgement, and having an emergency supply of milk were common. In later months, having a supply of milk available so that someone else could feed their infant was common.ConclusionsClinicians, health educators, WIC staff, and others working with WIC families can promote optimal expressed milk feeding and storage practices. Extra attention and support may be especially important in the first months postpartum when milk expression is common. Support for persons who are expressing milk can be tailored for reasons of milk expression.
Progressive politics and populism: Classes of labour and rural–urban political sociology—An introduction to the special issue
Authors: Pattenden Jonathan 
Published: January 2023

AbstractThis special issue analyses the prospects for a progressive politics against right‐wing populism and capitalism. Taken as a whole, its articles underline the need to understand progressive movements as encompassing agrarian, rural, and urban settings and as socially rooted among labourers and petty commodity producers that do not accumulate (classes of labour), which includes the majority of farmers. Most of the world's rural population now reproduce themselves to some degree in towns and cities, which necessitates further development of a rural–urban political sociology. Articles in the special issue discuss existing and potential organizations and networks of classes of labour. They point to the politicalpotentialof migrant populations to erode the social divisions of race, ethnicity, and nationality that capitalism and right‐wing populism construct to defend their interests. They contribute to understanding of why some members of classes of labour support racist nationalist populisms that pit them against fellow members of classes of labour. And they show why national contexts matter. Forms of capitalist government, including varieties of populism, are linked to world‐historical dynamics of accumulation and reproduction, as well as racialized class relations, and constrain routes to progressive politics in different ways. Analysis of them can inform counter‐strategies.