bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-Contrast Ultrasound Image Analysis for Spatial and Temporal Distribution of Blood Flow After Spinal Cord Injury
Authors: Routkevitch Denis , Soulé Zoe , Kats Nicholas , Baca Emily , Hersh Andrew M. , Kempski-Leadingham Kelley M. , Menta Arjun K. , Bhimreddy Meghana , Jiang Kelly , Davidar A. Daniel , Smit Constantin , Theodore Nicholas , Thakor Nitish V. , Manbachi Amir 
Published: September 2023

Abstract
Ultrasound technology can provide high-resolution imaging of blood flow following spinal cord injury (SCI). Blood flow imaging may improve critical care management of SCI, yet is limited clinically by the invasive nature of contrast agent injection required for high-resolution, continuous monitoring. In this study, we aim to establish non-contrast ultrasound as a clinically translatable imaging technique for spinal cord blood flow via comparison to contrast-based methods and by measuring the spatial distribution of blood flow after SCI. A rodent model of contusion SCI at the T12 spinal level was carried out using three different impact forces. We compared images of spinal cord blood flow taken using both non-contrast and contrast-enhanced ultrasound. Subsequently, we processed the images as a function of distance from injury, yielding the distribution of blood flow through space after SCI, and found the following. (1) Both non-contrast and contrast-enhanced imaging methods resulted in similar blood flow distributions (Spearman’s ρ = 0.55, p < 0.0001). (2) We found an area of decreased flow at the injury epicenter, or umbra (p < 0.0001). Unexpectedly, we found increased flow at the periphery, or penumbra (rostral, p < 0.05; caudal, p < 0.01), following SCI. However, distal flow remained unchanged, in what is presumably unaffected tissue. (3) Finally, tracking blood flow in the injury zones over time revealed interesting dynamic changes. After an initial decrease, blood flow in the penumbra increased during the first 10 minutes after injury, while blood flow in the umbra and distal tissue remained constant over time. These results demonstrate the viability of non-contrast ultrasound as a clinical monitoring tool. Furthermore, our surprising observations of increased flow in the injury periphery pose interesting new questions about how the spinal cord vasculature reacts to SCI, with potentially increased significance of the penumbra.
Polypyrrole-wool composite with electrical heating properties fabricated via layer-by-layer method
Authors: Lee Suhyun 
Published: September 2023

Abstract
Conductive polymer-textile composites with electric heating features were developed by the in-situ polymerization of polypyrrole on wool-felt fabrics. In particular, the amount and uniformity of polypyrrole deposition inside the fabrics was controlled by consecutive cycles of layer-by-layer (LBL) in-situ polymerization. To analyze the interaction principle of wool fiber and polypyrrole and to explore the processing conditions that can maintain the mechanical properties of the composites, the appearance, add-on, and electrical heating performance were evaluated according to the number of LBL cycles. The polypyrrole formed spherical particles on the wool-felt after polymerization. As the number of LBL cycles increased, more polypyrrole particles were deposited. In the case of mechanical properties, the tensile strength and bending rigidity increased with the polypyrrole deposition, and the strain decreased; however, the difference according to the number of LBL cycles was insignificant. However, the electrical properties were implemented in the polypyrrole-wool composites by polymerization, and a rapid decrease in the surface resistance was observed until the second LBL cycle. In the case of electrical heating performance, the surface temperature increased by up to 15.5 ℃ when 12 V voltage was applied, and the surface temperature increased linearly as the number of LBL cycles increased. This electrical heating performance maintained a high temperature for a certain period, even after removing the voltage, owing to the low thermal conductivity of the wool fiber. In addition, the polypyrrole conductive layer maintained excellent conductivity even after repeated abrasion owing to the improvement in uniformity by the LBL cycles.
In vitro plant regeneration of Artocarpus heterophyllus Lam. using shoot tips of mature trees
Authors: Das Shayantani , Mathew Binu , Dang Jiten Chandra 
Published: September 2023

Abstract
Jackfruit (Artocarpus heterophyllus Lam.) belonging to the family Moraceae is the largest fruit in the world. Jackfruit is a cross-pollinated species exhibiting wide genetic variation resulting in heterozygosis and degradation of the quality of seedlings. Additionally, due to the recalcitrant nature of the jackfruit seed, its storage, even for a short time, results in loss of viability and poor germination. Hence, propagation of the jackfruit plant from seeds is not recommended for commercial cultivation. Traditional ex vitro vegetative propagation methods such as budding, grafting, and cutting, show a slow growth rate, and the process is cumbersome and time consuming. To overcome these challenges and to produce true-to-type jackfruit plants for quality maintenance and sustenance, in vitro propagation using shoot tips from mature jackfruit trees was undertaken. The actively growing shoot tips from mature jackfruit trees were excised, washed, and sterilized with 70% ethanol and 0.1% HgCl2. This was followed by inoculating the explants on MS medium supplemented with various combinations of plant growth regulators to induce shoot proliferation and subsequent rooting. In the present study, the highest rate of shoot initiation (93.33%) with the highest number of shoots (5.93) per shoot explant was achieved on MS medium fortified with 3.0 mg/L BAP and 2.0 mg/L TDZ. The excised microshoots rooted on half-strength MS medium with 2.0 mg/L IBA induced the highest number of roots (8.07) per shoot. The in vitro obtained jackfruit plantlets were acclimatized the best in vermicompost-containing potted plants with a 95% survival rate. The gradually acclimatized jackfruit plants were further transferred to natural conditions, where 90% of the plants survived successfully.
Genome-wide association studies for identification of novel QTLs related to agronomic traits in Horsegram (Macrotyloma uniflorum)
Authors: Sharma Ankita , Chahota Rakesh Kumar 
Published: September 2023

Abstract
Horsegram (Macrotyloma uniflorum) is an important legume crop well adapted to harsh environments and has significant nutritional value. It is also well recognised due to its nutritional value, health benefits, drought tolerance, and ability to improve soil fertility. It is a versatile crop used in various dishes and is a valuable addition to any diet. However, in-depth molecular analysis must be improved to understand the molecular architecture regulating the essential traits. To achieve this, the study utilized a genome-wide association mapping approach using 88 horsegram accessions genotyped with 55656 single nucleotide polymorphisms (SNPs). A total of 54271 SNPs were mapped to the reference genome. Phenotypic data were collected for four agronomic and yield-related traits Plant height, Days to maturity, days to flowering and number of branches per plant. These traits played a significant role in plant growth, development, protection, and crop yield. The study identified 79 significant SNP-trait associations for the traits under study. The identified SNPs were in 8 chromosomes. The study also identified several novel genomic regions associated with the traits considered, providing new insights into the genetic basis of these essential traits in horse gram. Overall, the study highlights the potential of genome-wide association mapping for identifying genomic regions associated with important agronomic and yield-related traits in horsegram. This could facilitate the development of improved horsegram varieties through marker-assisted breeding programs and overcoming the morphological selection of desirable genotypes in the background of narrow genetic base.
Feasibility of a novel wearable thermal device for management of bothersome hot flashes in patients with prostate cancer
Authors: Peeke Pamela , Billes Sonja , Vetter Andrew , Naghavi Nader , Le Diana , Smith Matthew , Morgans Alicia 
Published: September 2023

Abstract
BACKGROUND
This single-arm prospective study evaluated the feasibility of a novel wrist-worn thermal device that applies cooling to the inside of the wrist for management of bothersome hot flashes in prostate cancer survivors.
METHODS
57 individuals were enrolled and instructed to use the device as needed for 4 weeks. The primary outcome was thermal device usage (hours and sessions per day). Additional outcomes included the change in patient reported Hot Flash Related Daily Interference Scale (HFRDIS, range 0–10) and Patient Reported Outcomes Measurement Information System Sleep Disturbance 4a (PROMIS SD T-score, range 0-100) and Sleep Related Impairment 8a (PROMIS SRI T-score, range 0-100). Study procedures were conducted remotely from May to Dec 2021 in the US.
RESULTS
44 participants completed the study and 39 had retrievable usage data. The mean ± SD age was 67 ± 6 years and 5 ± 5 years since cancer diagnosis. Baseline scores indicated moderate hot flash interference (HFRDIS mean ± SD: 4.3 ± 2.0) and mild sleep disturbance (PROMIS SD: 56.4 ± 6.7). Mean ± SD use of the thermal device was 3.2 ± 2.5 hours/day and 7.6 ± 3.6 sessions/day. Most (67%) participants reported using the device 7 days/nights each week. Statistically significant improvements from baseline at Week 4 were observed for HFRDIS (mean ± SE change: -1.1 ± 0.3), PROMIS SD (-6.0 ± 1.0), and PROMIS SRI (-5.5 ± 1.2) scores (all p < .001). Improvements were also observed in subjective measures of hot flashes and night sweats. The majority (69%) of participants reported that the thermal device was effective at helping them manage hot flashes. No adverse events were reported.
CONCLUSIONS
Results support the feasibility of using the thermal device for management of bothersome hot flashes in prostate cancer survivors. Future randomized controlled studies are warranted to evaluate patient reported outcomes related to frequency and severity of hot flashes, sleep quality, fatigue, and overall quality of life.
SHED-derived exosomes attenuate trigeminal neuralgia after CCI of the infraorbital nerve in mice via the miR-24-3p/IL-1R1/p-p38 MAPK pathway
Authors: Guo Rong , Fang Yuxin , Zhang Yuyao , Liu Liu , Li Na , Wu Jintao , Yan Ming , Li Zehan , Yu Jinhua 
Published: September 2023

Abstract
Background: Microglial activation in the spinal trigeminal nucleus (STN) plays a crucial role in the development of trigeminal neuralgia (TN). The involvement of adenosine monophosphate-activated protein kinase (AMPK) and N-methyl-D-aspartate receptor 1 (NMDAR1, NR1) in TN has been established. Initial evidence suggests that stem cells from human exfoliated deciduous teeth (SHED) have a potential therapeutic effect in attenuating TN. In this study, we propose that SHED-derived exosomes (SHED-Exos) may alleviate TN by inhibiting microglial activation. This study sought to assess the curative effect of SHED-Exos on a unilateral infraorbital nerve chronic constriction injury (CCI-ION) model in mice to reveal the role of SHED-Exos in TN and further clarify the potential mechanism.
Results:Animals subjected to CCI-ION were administered SHED-Exos extracted by differential ultracentrifugation. SHED-Exos significantly alleviated TN in CCI mice (increasing the mechanical threshold and reducing p-NR1) and suppressed microglial activation (indicated by the levels of TNF-α, IL-1β and IBA-1, as well as p-AMPK) in vivo and in vitro. Notably, SHED-Exos worked in a concentration dependent manner. Mechanistically, miR-24-3p-upregulated SHED-Exos exerted a more significant effect, while miR-24-3p-inhibited SHED-Exos had a weakened effect. Bioinformatics analysis and luciferase reporter assays were utilized for target gene prediction and verification between miR-24-3p and IL1R1. Moreover, miR-24-3p targeted the IL1R1/p-p38 MAPK pathway in microglia was increased in CCI mice, and participated in microglial activation in the STN.
Conclusions: miR-24-3p-encapsulatedSHED-Exos attenuated TN by suppressing microglial activation in the STN of CCI mice. Mechanistically, miR-24-3p blocked p-p38 MAPK signaling by targeting IL1R1. Theoretically, targeted delivery of miR-24-3p may offer a potential strategy for TN.
Development of a Simple Test to Quantify the Consolidation Properties of Liquefied Granular Materials
Authors: Tauskela Lisa , Adamidis Orestis , Take Andy 
Published: September 2023

Abstract

Liquefaction can have devastating consequences by causing increased mobility of debris flows, tailings dam breaches, and settlement following seismic shaking. Observations on the consolidation behaviour of liquefied soils in 1-g or centrifuge shake table tests have permitted significant advancements in analytical and numerical methods to predict the rate and magnitude of consolidation settlement. However, advanced consolidation models introduce material parameters which are currently difficult to define quickly and at low cost. The objective of this paper is to demonstrate the development of a simple, low-cost test that can be used to quickly estimate the spatially and temporally varying coefficient of consolidation, which controls post-liquefaction settlements. Using the proposed simple set-up, experiments were conducted on four uniformly graded sands of varying grain size and on one well-graded mixture. A range of analytical and numerical approaches from literature were assessed for their ability to back-analyse the observed pore pressure dissipation and settlement. Estimated values for the coefficient of consolidation were comparable between models and estimates of surface settlement matched well the experimental results. The simplicity of the proposed test combined with its low-cost and mobile nature, raise significant possibilities for quick estimations of the evolution of the coefficient of consolidation post-liquefaction.
The efficacy and safety of continuous blood purification in neonates with septic shock and acute kidney injury: a two-center retrospective study
Authors: Xu Jinglin , Sun Yifan , Zhang Weifeng , Chu Xiaoyun , Yang Hongyuan , Cai Cheng , Chen Dongmei 
Published: September 2023

Abstract
Purpose
To investigate the efficacy and safety of continuous blood purification (CBP) in neonates with septic shock and acute kidney injury (AKI).
Methods
A retrospective study was conducted in two tertiary care children's hospitals between January 2015 and May 2022.
Results
In this study, 26 neonates with septic shock and AKI were included with a mortality of 50%. Fourteen neonates (53.8%) received continuous veno-venous hemodiafiltration, while 12 (46.2%) received continuous veno-venous hemofiltration. Compared with the indexes before CBP, urine output increased 12h after CBP initiation (P = 0.003), and serum creatinine decreased (P = 0.019). After 24h of CBP, blood urea nitrogen had decreased (P = 0.006), and mean arterial pressure had increased (P = 0.007). At the end of CBP, vasoactive inotropic score and blood lactate were decreased (P = 0.035 and 0.038), and PH was increased (P = 0.015). The most common complication of CBP was thrombocytopenia, and univariate analysis identified no risk factors for CBP-related death.
Conclusion
CBP can efficiently maintain hemodynamic stability, improve renal function, and has good safety in neonates with septic shock and AKI. However, the mortality remains high, and whether CBP improves the prognosis of neonates with septic shock and AKI remains unclear.
New random intelligent chemometric techniques for sustainable geopolymer concrete: Low-energy and carbon-footprint initiatives
Authors: Jibril Mahmud M. , Malami Salim , Jibrin Hauwa , jibrin umar , Duhu Mohammed , Usman Abdullahi , Ibrahim A. G , Ozsahin Dilber , Lawal Zaharaddeen Karami , Abba Sani 
Published: September 2023

Abstract
The construction industry, being a significant contributor to greenhouse gas emissions, facing considerable attention and demand on account of the increasing global apprehension regarding climate change and its adverse impacts on environments. Geopolymer shows itself as a viable and sustainable alternative to the Portland cement binder in civil infrastructure applications, offering a low-energy, low-carbon footprint solution. This study evaluates five models: Random Forest (RF), Robust Linear Regression (RL), Recurrent Neural Network (RNN), Response Surface Methodology (RSM), and Regression Tree (RT). The RL and RT models were utilized in the prediction of GPC Compressive strength (CS), employing the Matlab R19a regression learner APP. The RNN model was implemented using the Matlab R19a toolkit. Furthermore, the RF model was developed using R studio version 4.2.2 programming code, and the RSM model was constructed using the Minitab 18 toolbox. EViews 12 software was utilized for both pre-processing and post-processing of the data. Additionally, it was employed to convert the non-stationary data into stationary data in order to obtain accurate results. The input variables included SiO2/Na2O (S/N), Na2O (N), Water/Binder Ratio (W/B), Curing Time (CT), Ultrasonic Pulse Velocity (UPV), and 28-day Compressive Strength (Mpa) (CS) as the target variable. The findings of the study indicate that the RMS-M3 model exhibited superior performance compared to all other models, demonstrating a high level of accuracy. Specifically, the Pearson correlation coefficient (PCC) was calculated to be 0.994, while the mean absolute percentage error (MAPE) was found to be 0.708 during the verification phase.
On the shear-thinning of alkanes
Authors: Gao Hongyu , Müser Martin 
Published: September 2023

Abstract
The approximate power-law dependence ofthe apparent viscosity of liquids on shear rate is of-ten argued to arise from a distribution of energy barri-ers. However, recent work on the Prandtl model, whichconsists of a point mass being dragged by a damped,harmonic spring past a sinusoidal potential, revealed asimilar dependence of the friction on velocity as that ofmany liquids. Here, we demonstrate that this correla-tion is not only qualitative but can also be made quan-titative over a broad temperature range using merelythree dimensionless parameters, at least for alkanes, inparticular hexadecane, at elevated pressure p. Theseand other observations made on our all-atom alkanesimulations at elevated pressure point to the existenceof an elementary instability causing shear thinning. Inaddition, the equilibrium viscosity shows power law de-pendence on p near the cavitation pressure but an expo-nential dependence at large p, while the additional pa-rameter(s) in the Carreau-Yasuda equation comparedto other rheological models turn out justifiable.
Different Machine Learning Applications for Crop Classification via Multi-Temporal Sentinel-2 Images and Farmer Declaration Parcels
Authors: şimşek fatih fehmi 
Published: September 2023

Abstract
In this study, the performances of Random Forests (RF), Artificial Neural Networks (ANN), Support Vector Machine (SVM) and Extreme Gradient Boosting (XGBoost) algorithms in agricultural crop classification were compared using multi-temporal Sentinel-2 images. The study area is located within an area of approximately 45* 45 km2 within the borders of Çukurova Plain. Within the scope of the study, agricultural crop pattern classification including corn, cotton, wheat, sunflower, sunflower, watermelon, peanut, and citrus trees, as well as double crop corn, soya, and cotton crops planted after wheat using RF, ANN, SVM, XGBoost algorithms with multi-time Sentinel-2 images of 2021. The study used parcels registered in the Farmer Registration System (FRS) as reference data. Before defining the parcels that are called Farmer Declaration Parcels (FDP) as ground truth data, pre-editing and rule-based deletion operations were performed, afterwards false and incorrect declarations were eliminated.10 bands (B2, B3, B4, B5, B6, B7, B8, B8A, B11, B12) of Sentinel-2 imagery from 11 different dates and Enhanced Vegetation Index (EVI) were used. All classification results showed a high overall accuracy (OA) ranging from 85% to 92%. As a result of the classification using a total of 121 different features, the highest overall accuracy OA (92.14%) belongs to the XGBoost algorithm. XGBoost algorithm was followed by RF (89.15%), SVM (86.14%) and ANN (85.48%). In all algorithms, although cotton, maize and wheat gave the highest accuracy in the classification results, double crops (wheat-maize, wheat-soybean, wheat-cotton) especially those with very close phenological periods, could not reach very high accuracy values. As a result of the study, it was observed that crops at different phenological stages achieved high classification accuracy using all algorithms, while crops at very similar phenological stages lower classification results. With the methodology applied in this study, a large number of ground truth data were generated from FDP plots and used for classification.
Research on vibration property of Picea wood for piano sound quality neural network and ant colony algorithm
Authors: Yang Yang , Jie Shi , Yanling Guo , Zhenbo Liu 
Published: September 2023

Abstract
With its characteristics of wide range and large volume variation, piano has an unshakable position in the Musical Instruments and is widely loved by numerous people. In a upright piano, the basic function of the piano sound board (resonance board) is used to expand the sound emitted by the string. Different wood species would produce different vibration amplitudes and resonance effects. If the other parts of the two pianos are exactly the same, their advantages and weaknesses can only be determined by the resonance board, so the resonance version of the material is particularly important. Based on the vibration theory of piano resonance plate, this study analyzed the vibration characteristics of the resonance plate and used the BP neural network ACO-BP optimized by ant colony algorithm. Using the dynamic elastic modulus, the elastic modulus and shear modulus ratio, acoustic radiation damping coefficient and acoustic impedance of the wood species of Russian Far East Picea koraiensis Nakai, Picea jezoensis, Picea spinlosa and Picea sitchensis Carr. as the prediction inputs, the accuracy of the model for predicting the musical instrument grade reached 95%. It is of great value for improving the acoustic quality of piano by establishing the corresponding acoustic quality evaluation system of national Musical Instruments and deeply investigating the prediction method of the parameters of the acoustic evaluation system to realize the transition from the subjective evaluation to objective evaluation.