bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the study of Rainbow Antimagic Coloring of Special Graphs
Authors: Dafik Dafik , Wahidah Riniatul Nur , Albirri Ermita Rizki , Husain Sharifah Kartini Said 
Published: May 2023

Let be a connected graph with vertex set and edge set . The bijective function is said to be a labeling of graph where is the associated weight for edge . If every edge has different weight, the function is called an edge antimagic vertex labeling. A path in the vertex-labeled graph , with every two edges satisfies is said to be a rainbow path. The function is called a rainbow antimagic labeling of , if for every two vertices , there exists a rainbow path. Graph admits the rainbow antimagic coloring, if we assign each edge with the color of the edge weight . The smallest number of colors induced from all edge weights of edge antimagic vertex labeling is called a rainbow antimagic connection number of , denoted by . In this paper, we study rainbow antimagic connection numbers of octopus graph , sandat graph , sun flower graph , volcano graph and semi jahangir graph Jn.
Comparing Several Missing Data Estimation Methods in Linear Regression;Real Data Example and A Simulation Study
Authors: Fitrianto Anwar , Jia Jap Ee , Susetyo Budi , Rahman La Ode Abdul 
Published: May 2023

Analysis on incomplete could lead to biased estimation when using standard statistical procedure since it ignores the missing observations. The disadvantage of ignoring missing data is that the researcher might not have enough data to conduct an analysis. The main objective of the study is to compare the performance between listwise deletion (LD), mean substitution (MS) and multiple imputation (MI) method in estimating parameters. The performance will be measured through bias, standard error and 95% confidence interval of interested estimates for handling missing data with 10% missing observations. A complete empirical data set was used and assumed as population data. Ten percent of total observations in the population ere set as missing arbitrarily by generating random numbers from a uniform distribution, . Then, bias of parameter estimates and confidence interval of parameter estimates are calculated to compare the three methods. A Monte Carlo simulation was carried out to know the properties of missing data and investigated using simulated random numbers. Simulation of 1000 sampled data with 20, 50, and 100 observations and each sample is set to have 10% missing observations. Standard statistical analyses are run for each missing data and get the average of parameter estimates to calculate the bias and standard error of parameter estimates for every missing data method. The analysis was conducted by using SAS version 9.2. It was found that the MI method provided the smallest bias and standard error of parameter estimates and a narrower confidence interval compared to the LD and MS methods Meanwhile, the LD method gives a smaller bias of parameter estimates and standard error for small sample size of missing data. And, MS method is strongly recommended not to use for handling missing data because it will result in large bias and standard error of parameter estimates.
What Factors Are Associated with Clinical Trial Discontinuation in Orthopaedic Surgery
Authors: Hecht Christian J. , Guyler Maura R. , Shah Aakash , Burkhart Robert J. , Kamath Atul F. 
Published: May 2023

Background:
Clinical trials play a crucial role in advancing medical knowledge and have the potential to change standards of care. The present study evaluated the prevalence of discontinued clinical trials in orthopaedic surgery. Additionally, we sought to identify the study characteristics associated with and the rationale behind trial discontinuation.

Methods:
A cross-sectional survey of orthopaedic clinical trials using the ClinicalTrials.gov registry and results database was performed for trials between October 1, 2007, and October 7, 2022. Interventional trials listed as “completed,” “terminated,” “withdrawn,” or “suspended” were included. Study characteristics were collected and clinical trial abstracts were reviewed in order to assign the appropriate subspecialty category. A univariate linear regression analysis was performed to determine whether the percentage of discontinued trials changed between 2008 and 2021. Univariate and multivariable hazard ratios (HRs) were calculated to identify factors associated with trial discontinuation.

Results:
A total of 8,603 clinical trials were included in the final analysis, of which 1,369 (16%) were discontinued, with the highest rates of discontinuation found in oncology (25%) and trauma (23%). The most common rationales for discontinuation were insufficient patient accrual (29%), technical or logistical issues (9%), business decision (9%), and lack of funding or resources (9%). Industry-funded studies were more likely than government-funded studies to be discontinued (HR: 1.81; p < 0.001). There was no change in the percentage of discontinued trials for each orthopaedic subspecialty between 2008 and 2021 (p = 0.21). As shown on multivariable regression analysis, trials for devices (HR: 1.63 [95% confidence interval, 1.20 to 2.21]; p = 0.002) and drugs (HR: 1.48 [1.10 to 2.02]; p = 0.013) as well as Phase-2 trials (HR: 1.35 [1.09 to 1.69]; p = 0.010), Phase-3 trials (HR: 1.39 [1.09 to 1.78]; p = 0.010), and Phase-4 trials (HR: 1.44 [1.14 to 1.81]; p = 0.010) had a higher likelihood of early discontinuation. However, pediatric trials were less likely to be discontinued (HR: 0.58 [0.40 to 0.86]; p = 0.007).

Conclusions:
The results of the present study suggest the need for continued efforts to ensure the completion of orthopaedic clinical trials in order to limit publication bias and to employ resources and patient contributions more efficiently for research.

Clinical Relevance:
Discontinued trials contribute to publication bias, which limits the comprehensiveness of the literature available to support evidence-based patient care interventions. Therefore, identifying the factors associated with and the prevalence of orthopaedic trial discontinuation encourages orthopaedic surgeons to design future trials to be more resistant to early discontinuation.
Integrated Workflow with Static and Dynamic Geomechanical Modelling for Hydraulic Fracturing Optimization
Authors: Ma Jun , Wang Junping , Fan Qinghu , Jiao Shujiang , Chen Liang , Guo Changyong , Hu Zhangming , Liu Xiaodong , Jiang Xinmiao , Wang Yuan , Huang Xingning , Xu Hanbing 
Published: May 2023

Abstract
How to realize the efficient development of tight oil reservoir is a key and difficult problem for the unconventional resources of China. To realize the effective development of tight oil reservoir, it is necessary to the reservoir stimulation technology to improve the seepage capacity of low permeability reservoirs and increase the productivity of wells. Reservoir geomechanics is one of the main factors affecting hydraulic fracturing effect. Domestic and foreign experts have conducted a large number of studies on the characteristics of reservoir geomechanics. However, most of them studied the regional geomechanical characteristics based on logging data, lithology characteristics and three-dimensional seismic. Such static geomechanics studies can better reflect the in-situ stress characteristics of reservoirs before hydraulic fracutring but also have limitations and uncertainties in the understanding of regional geomechanical characteristics. Based on the one-dimensional geomechanical study, this paper uses structural characteristics and seismic attributes to study the three-dimensional mechanics spatial distribution characteristics of reservoirs. On this basis, this paper performs dynamic (4D) stress field simulation combined with real-time fracturing treatment and microseismic monitoring data. The research results can be used to guide the design of horizontal wells fracturing design and provide strong technical support for the production capacity construction. This paper studies the static and dynamic geomechanics of Baikou Quan Formation in Da 13 block, Junggar Basin and describes the research methods and processes and applies them to the design and optimization of reservoir stimulation schemes. The research results can help reduce operational costs and improve the efficiency of measures and serves as technical support for the efficient development of tight reservoirs in China.
Successful Applications of Insert Valve Carrier System in Reinstating Downhole Safety Valve Functionality
Authors: Sulaiman A. Y. , AlHammadi I. , Al Ali S. , El-Sheikh H. , Al Ghafeli S. K. , Shokry A. , Abdi R. M. , Abdulla M. F. , Yakovlev T. , Ross S. 
Published: May 2023

Abstract
As wells completed with wireline retrievable downhole safety valves are becoming mature, issues related to seal bore and nipple profile tend to develop, causing the safety valve to be non-integral. Without a fully functioning downhole safety valve, these wells cannot produce and must be shut in. One option to overcome this issue is to utilize an Insert Valve Carrier (IVC) connected to the existing downhole safety valve (DHSV). The IVC has an anchoring mechanism to hang the system on depth, replacing the function of the damaged nipple. Also, it is equipped with upper and lower sealing elements to seal across the existing control line outlet in the tubing providing hydraulic fluid to operate the safety valve. An electronic setting tool sets the anchors at the pup joint slightly above the safety valve nipple while positioning the sealing elements across the control line outlet. The system is simple to use and can easily be set with Slickline, Electric Line, or Coiled Tubing with CCL capability for correlation or a No-go assembly.
Several successful jobs were conducted between 2021-2022 in 4-1/2″ and 7″ completions in the Offshore Abu Dhabi field. Before mobilization, System Integrity Test is performed to ensure the system passes the pressure test and the safety valve functions properly. In this operation, the IVC and the safety valve were set using an Electric Line, taking advantage of real-time reading from the CCL for correlation. Once on depth, a signal was sent from the surface, setting the anchors and sealing elements. A normal procedure to apply pressure in the control line was performed. When the pressure holds, it provides a positive indication that the packing elements seal properly. An inflow test on the flapper was performed to confirm its integrity. Following the installation, flow tests were performed at different rates to ensure the system worked fine and evaluate the potential. This system has successfully restored the downhole safety valve functionality, which permits the wells to produce again after being inactive for a long time. In addition, the success of this system eliminates the need for expensive workovers.
Domestic Cat as an Exotic Predator – Report of Predation of Native and Invasive Species in an Urban Area in Southern Brazil
Authors: de Freitas Luiza Isaia , Lanzanova Thais Ito Isaia , Shibuya Fabio Yuji , de Andrade Gabriela Monteiro , Barraza Vanessa Cirinéa Tapia , Dilkin Paulo , Botton Sônia de Avila , Santos Helton Fernandes dos 
Published: May 2023

Abstract

Domestic cats (Felis catus) are listed among the 100 worst invasive species with the most impact on the environment and conservation, threatening a variety of native and even threatened animal species. Data indicate that they are responsible for the extinction of 33 species of birds. The objective of this work is to describe the predation of native and exotic species of fauna by a wildered domestic feline, specifically to bring data from the preyed species and data from the existing bibliographic of the predation by felines in the country. This is an observatory study, where the prey slaughtered and brought by the community cat were cataloged and listed over a period of 30 days in the summer of 2020. The animal brought the prey to the feeding place and dormitory, in front of one of the houses in which it received care. The study site is in the Camobi neighborhood, in the municipality of Santa Maria, state of Rio Grande do Sul, Brazil. Geographical location 29°41'47.9"S 53°44'20.4"W. This is the first report of the predation of two bird species (Falco sparveriusandLeptotila verreauxi)and two Squamatas (TupinambisandPhilodryas olfersii)in Brazil. The results obtained may contribute to reduce the lack of information regarding the impacts ofFelis catusand support the need to implement management policies and environmental education, aiming to combat the abandonment of domestic animals and encourage practices such as castration and responsible adoption of animals.
Adaptive Methods for Revenue Model learning of a Slice Broker in the Presence of Adversaries
Authors: Khan Md Muhidul Islam , Nencioni Gianfranco 
Published: May 2023

Abstract

In the Fifth Generation (5G) of mobile networks, Multi-Access Edge Computing (MEC) refers to the deployment of computing resources closer to the end-users for improved service delivery. In the context of 5G MEC, the slice broker plays a crucial role in managing the allocation of resources among the different network slices, which are logical networks on top of a shared infrastructure. The slice broker is a business entity that acts as an intermediary between the slice tenants and the infrastructure provider and is responsible for allocating resources (such as CPU, memory, and network bandwidth) required to set up the network. The slice broker must ensure that resources are allocated in a way that the revenue is maximized. In a dynamic environment, the slice broker must learn the revenue model adaptively and online. Adversaries can significantly reduce the revenue by misleading the system about the resources pretending to be selfish nodes or creating noise. The slice broker should learn the revenue model in the presence of adversaries. We apply cooperative deep reinforcement learning with consensus mechanism and consensus deep learning to learn the revenue model adaptively. We also compare our proposed methods with the reference solution. Simulation results show that our proposed methods, especially the cooperative version, outperform the reference solution.
Tissue-location specific transcription programs drive tumor initiation dependencies in colon cancer
Authors: Easwaran Hariharan , Yang Lijing , Tu Lei , Petkovich Daniel , Thursby Sara-Jayne , Bisht Shilpa , Mao Yiqing , Gabrielson Kathy , Yen Ray-Whay Chiu , Largent Tina , Brock Malcolm , Zahnow Cynthia , Baylin Stephen 
Published: May 2023

Abstract
It is unknown why cancers of the same tissue-type but in anatomically distinct locations exhibit different molecular dependencies for tumorigenesis. Proximal and distal colon cancers (CC) exemplify such characteristics, with BRAFV600E predominantly occurring in proximal CC along with increased DNA methylation phenotype. Using mouse colon organoids, we show that proximal and distal colon stem cells have distinct transcriptional programs regulating stemness and differentiation. The homeobox transcription factor, Cdx2, frequently silenced by DNA methylation in proximal colon cancers, was identified as a key mediator of the differential transcriptional programs. Cdx2-mediated proximal colon-specific transcriptional program is concurrently tumor suppressive, and its loss is critical for BRAFV600E-driven transformation of proximal colon stem cells. Human proximal CC with CDX2-downregulation showed similar transcriptional program as the mouse proximal organoids with Cdx2 loss. Our results suggest a model in which developmental transcription factors maintain tissue-location specific transcriptional programs that create tissue-type origin specific dependencies for tumor initiation.
Primordial and 244Pu-derived xenon missing from Earth's convecting mantle
Authors: Bekaert D.V. , Caracausi A. , Byrne D. J. , Caro G. , Broadley M.W. , Barry P.H. , Marty B. , Seltzer A.M. 
Published: May 2023

Abstract

Mantle-derived noble gases are exceptional recorders of the history of planetary volatile elements (C, N, water), which are key to the development of life on Earth1,2. For example, the relative proportions of 129Xe derived from radioactive-decay of extinct 129I and 136Xe from fission of extinct 244Pu as well as extant 238U provide crucial timestamps for mantle volatile loss and for the formation of a habitable surface environment3,4,5. However, the low abundance of heavy noble gases (Ar, Kr, Xe) in mantle-derived samples constitutes a major analytical challenge that has thus far precluded a comprehensive understanding of mantle volatile evolution6,7. Here, we employ dynamic mass spectrometry8,9 to measure convecting mantle-derived Ar-Kr-Xe isotopes in Mt. Etna (Sicily) and Eifel (Germany) volcanic gases at ultra-high precision. Our data reveal that the fractions of (i) total fissiogenic 136Xe from 244Pu-Xe (denoted 136XePu/136XeTF) and (ii) stable Kr and Xe from primordial (i.e., accretionary) sources are both significantly lower than previous estimates suggest. The latter point requires pervasive and almost complete overprinting by subduction-derived surface components. The large 129Xe excess from 129I decay implies that the lack of XePu cannot be ascribed to an extensive loss of short-lived radionuclide products via mantle degassing. Instead, missing XePu may require (i) a reevaluation of the initial (chondritic) Pu/U within Earth10 or (ii) significant fractionation of Pu/U during early Earth processes, both of which would have far-reaching implications for modeling of terrestrial Xe evolution11. Notably, quantitative incompatible element extraction to the Hadean crust and subsequent reintroduction of 238U via subduction (after 244Pu had become extinct, i.e., after ~ 500 Myr) could have contributed to lowering the ultimate 136XePu/136XeTF of the depleted upper mantle. This indicates that subduction quantitatively overprinted the compositions of both volatile (e.g., noble gases) and refractory (e.g., uranium) elements within Earth's mantle.
Evolution Characteristics and Its Driving factors of Production–Living–Ecological Space in typical hilly areas: A Case Study of Changshou District in China from 2000 to 2020
Authors: yang wen , Li Wei , Li Bin 
Published: May 2023

Abstract
In the context of sustainable territorial spatial development, the ecological functions of hilly areas are emphasized, and clarifying the evolutionary characteristics and drivers of production-living-ecology space (PLES) in hilly areas is important for optimizing regional development patterns and promoting environmental quality development. In this study, the current land use status and topographic data of typical hilly areas in southwest China (Changshou District, Chongqing) in 2000, 2010, and 2020 were selected, and the evolution characteristics of PLES and its driving factors were systematically studied by using land use transfer matrix, landscape index and geodetector. The results show that. (1) PLES shows a pattern of one decrease and two increases (production space decreasing year by year, living and ecology space increasing). (2) under the influence of hilly topography, the vertical variation of PLES is obvious with the threshold of 450m in elevation and 9° in slope. (3) PLES landscape diversity increases, dominance increases, and fragmentation increases. (4) Natural conditions, transportation location and socio-economics are important driving factors affecting the evolution of PLES patterns.
The Efficacy of HDDPiW-jSB Solution on Docetaxel-Induced Alopecia of Rats
Authors: Demir Bilgin , Demirci Buket , Tataroglu Canten , Barutca Sabri , Barutca Duygu 
Published: May 2023

Abstract

Objective: Chemotherapy induced alopecia (CIA) is one of the most common side effects in cancer patients, however; it doesn’t have an effective pharmacological treatment yet. In this study we aimed to research the protective effect of HDDPiW-jSB solution on docetaxel (DTX) -induced rat alopecia model.
Material and Methods: Docetaxel (10 mg/kg/week) was administered to the 6-8 months old rats for three weeks. HDDPiW-jSB solution was applied once or twice a week for 4 weeks beginning prior to one week before DTX. Rat hair follicles were evaluated with hematoxylin-eosin and immune-histochemical staining.
Results: In the first stage of this study, alopecia was successfully developed by DTX application. In the second stage, application of HDDPiW-jSB solution without DTX, didn’t change the study parameters significantly. In DTX-induced alopecic rat groups’ skin samples, the solution ameliorated the anagen hair follicle count and Bcl-2 values, especially when used as twice a week. Additionally, level of Caspase 3 was decreased. HDDPiW-jSB solution was safe when applied on the skin.
Conclusion: Topical HDDPiW-jSB solution could be effective and safe for the protection of DTX-induced alopecia in rat models.
Combined BBB-penetrant tyrosine kinase inhibitor and intracranial radiotherapy versus BBB-penetrant tyrosine kinase inhibitor alone for the treatment of EGFR-mutated non-small cell lung cancer patients with brain metastases
Authors: Chen You-Cong , Lee Cheng-Chia , Chiang Chi-Lu , Yang Huai-Che , Wu Hsiu-Mei , Chen Ching-Jen , Luo Yung-Hung , Hu Yong-Sin , Lin Chung-Jung , Chung Wen-Yuh , Shiau Cheng-Ying , Guo Wan-Yuo , Pan Hung-Chi , Lin Chun-Fu 
Published: May 2023

Abstract
Purpose
This study was to determine whether combining blood-brain-barrier-penetrant tyrosine kinase inhibitor (TKI), osimertinib, with intracranial radiotherapy (TKI + RT) would confer benefits exceeding those of osimertinib alone (TKI-alone) in terms of treatment outcomes among non-small cell lung cancer (NSCLC) patients with brain metastases and epidermal growth factor receptor (EGFR) mutation.
Methods
This single-center retrospective study focused on gamma-knife radiosurgery (GKRS) and whole brain radiotherapy (WBRT). Treatment outcomes included intracranial local tumor control, intracranial distant tumor control and overall survival (OS) rates.
Results
This study included 567 brain metastases in 69 patients: TKI-alone (n = 38) and TKI + RT (n = 31) including GKRS (n = 25) and WBRT (n = 6). Intracranial local tumor control at 36 months was significantly higher in the TKI + RT than in the TKI-alone (77% vs. 23%; p < 0.001). Intracranial distant tumor control was significantly higher in the TKI + RT than in the TKI-alone (median survival: 23.2 ± 1.5 vs. 8.7 ± 0.2 months; p < 0.001). We observed no difference between the two cohorts in terms of OS (p = 0.271). T790M point mutation (HR = 0.359, p = 0.008) and TKI + RT (HR = 0.396, p = 0.010) were positively correlated with intracranial local tumor control. The number of brain metastases was negatively correlated with intracranial distant tumor control (HR = 2.253, p = 0.034) and OS (HR = 2.049, p = 0.019).
Conclusions
The efficacy of osimertinib therapy for NSCLC patients with brain metastases and EGFR mutation was enhanced by combining this treatment with intracranial radiotherapy. Benefits were observed in terms of intracranial local control and distant control rates; however, no benefits were observed in terms of OS. Further prospective studies will be required to confirm these findings.