bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence of exhausted lymphocytes after the third anti-SARS-CoV-2 vaccine dose in cancer patients
Authors: Benitez Fuentes Javier David , Mohamed Mohamed Kauzar , de Luna Aguilar Alicia , Jiménez García Carlos , Guevara-Hoyer Kissy , Fernandez-Arquero Miguel , Rodríguez de la Peña M Antonia , Garciía Bravo Laura , Jiménez Ortega Alejandro Francisco , Flores Navarro Paloma , Bartolome Arcilla Jorge , Alonso Arenilla Bárbara , Baos Muñoz Elvira , Delgado-Iribarren García-Campero Alberto , Montealegre Sanz María , Sanchez-Ramon Silvia , Perez Segura Pedro 
Published: December 2022

IntroductionEvidence is scant regarding the long-term humoral and cellular responses Q7 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines in cancer patients after repeated booster doses. The possibility of T-cell exhaustion following these booster doses in this population has not yet been fully studied and remains uncertain.MethodsIn this single-center prospective observational study, we explored the specific humoral and cellular response to S1 antigen in 36 patients with solid malignancies at baseline, and after the second and third doses of the mRNA-1273 vaccine.ResultsA dual behavior was observed: 24 (66.7%) patients showed partial specific IFN-γ response after the second dose that was further enhanced after the third dose; and 11 (30.5%) already showed an optimal response after the second dose and experienced a marked fall-off of specific IFN-γ production after the third (4 patients negativization), which might suggest T cell exhaustion due to repetitive priming to the same antigen. One (2.8%) patient had persistently negative responses after all three doses. Seroconversion occurred in all patients after the second dose. We then studied circulating exhausted CD8+ T-cells in 4 patients from each of the two response patterns, those with increase and those with decrease in cellular response after the third booster. The patients with decreased cellular response after the booster had a higher expression of PD1+CD8+ and CD57+PD1+CD8+ exhausted T cells compared with those with an increased cellular response both in vivo and in vitro. The proportion of PD1+CD8+ and CD57+PD1+CD8+ exhausted T cells inversely correlated with IFN-γ production.DiscussionOur preliminary data show that the two-dose SARS-CoV-2 vaccine regimen was beneficial in all cancer patients of our study. An additional booster seems to be beneficial in suboptimal vaccine seroconverters, in contrast to maximal responders that might develop exhaustion. Our data should be interpreted with caution given the small sample size and highlight the urgent need to validate our results in other independent and larger cohorts. Altogether, our data support the relevance of immunological functional studies to personalize preventive and treatment decisions in cancer patients.
Efficacy evaluation of neoadjuvant chemotherapy in patients with HER2-low expression breast cancer: A real-world retrospective study
Authors: Tang Lingfeng , Li Zhenghang , Jiang Linshan , Shu Xiujie , Xu Yingkun , Liu Shengchun 
Published: December 2022

BackgroundTo characterize the clinicopathological features and evaluate the neoadjuvant chemotherapy (NACT) efficacy of patients with human epidermal growth factor receptor 2 (HER2)-low breast cancer.MethodsA total of 905 breast cancer patients who received 4 cycles of thrice-weekly standard NACT in the First Affiliated Hospital of Chongqing Medical University were retrospectively enrolled, including 685 cases with HER2-low expression and 220 cases with HER2-negative expression. Clinicopathological features were compared between patients with HER2-negative and HER2-low expression. Univariate and multivariate logistic regression analyses were used to find the independent factors of achieving a pathological complete response (pCR) after NACT.ResultsThere were significant differences in stage_N (P = 0.014), histological grade (P = 0.001), estrogen receptor (ER) status (P &lt; 0.001), progesterone receptor (PgR) status (P &lt; 0.001), NACT regimens (P = 0.032) and NACT efficacy (P = 0.037) between patients with HER2-negative and HER2-low expression breast cancer. In subgroup analysis, histological grade (P = 0.032), ER (P = 0.002), Ki-67 (P &lt; 0.001) and HER2 status (P = 0.025) were independent predictors of achieving a pCR in ER-positive breast cancer. And the nomogram for pCR in ER-positive breast cancer showed great discriminatory ability with an AUC of 0.795. The calibration curve also showed that the predictive ability of the nomogram was a good fit to actual observations. Then, in the analysis of ER-negative breast cancer, only stage_N (P = 0.001) and Ki-67 (P = 0.018) were independent influencing factors of achieving a pCR in ER-negative breast cancer.ConclusionHER2-low breast cancer was a different disease from HER2-negative breast cancer in clinicopathological features. Moreover, the NACT efficacy of HER2-low breast cancer patients was poorer.
Microstructural changes of white matter assessed with diffusional kurtosis imaging in extremely preterm infants with severe intraventricular hemorrhage
Authors: Guo Li-Min , Zhao Meng , Cai Yue , Li Na , Xu Xiao-quan , zhang Xuan , Zhang Jiu-Lou , Xie Qi-Lian , Li Si-si , Chen Xiao-Qing , Cui Shu-Dong , Lu Chao 
Published: December 2022

ObjectiveIntraventricular hemorrhage (IVH) is a serious neurological complication in premature infants. This study aimed to investigate the white matter impairments and neurodevelopmental outcomes of severe IVH in extremely preterm infants with gestation age less than 28 weeks.MethodsWe retrospectively evaluated the extremely preterm infants between 2017 and 2020. Neurodevelopmental outcomes were evaluated with the Bayley Scales of Infant and Toddler Development-III at 2 years of corrected age. Diffusional kurtosis imaging (DKI) was employed to evaluate the microstructural changes in white matter tracts. Mean kurtosis (MK) and fractional anisotropy (FA) values of DKI were measured in the brain regions including posterior limbs of the internal capsule (PLIC) and the corpus callosum at term equivalent age.ResultsOf 32 extremely preterm infants with severe IVH during the follow-up period, 18 cases were identified as neurodevelopmental impairments. The delay rates of motor and language were 58.4% and 52.7%. The cases with neurodevelopmental impairments had lower MK and FA values in both bilateral PLIC and the corpus callosum. The analysis of multivariable regression models predicting motor and language outcomes at 2 years of corrected age, showed that the decreases of MK values in both PLIC and the corpus callosum at the term equivalent age contributed to a significantly increased risk of neurodevelopmental impairments (all p &lt; 0.05). During follow-up period, obvious loss of nerve fiber bundles was observed with DKI tractography.ConclusionMotor and language abilities at age 2 years were associated with MK values of DKI at the term equivalent age in both PLIC and the corpus callosum of extremely preterm infants with severe IVH. The evaluation of white matter microstructural changes with MK values might provide feasible indicators of neurodevelopmental outcomes of extremely preterm infants with severe intraventricular hemorrhage.
Low-dose esketamine for the prevention of emergency agitation in children after tonsillectomy: A randomized controlled study
Authors: Li Qi , Fan Jiaming , Zhang Wangping 
Published: December 2022

Background: Emergency agitation is a common postoperative complication in pediatric patients after general anesthesia. The aim of this study was to explore the effects of a low dose of esketamine on emergency agitation in children following tonsillectomy.Materials and Methods: Eighty children were recruited prospectively to this study and divided into the esketamine group and the control group (40 cases in each group). The induction and maintenance of anesthesia were the same in both groups. At the end of surgery, the esketamine group received 0.25 μg/kg esketamine, while the control group received the same volume of normal saline. The extubation time, time to eye opening, Ramsay sedation scale and time to discharge from the post-anesthesia care unit (PACU) were recorded during post-anesthesia care unit. Postoperative complications, such as emergency agitation, respiratory depression, hypertension, tachycardia, nightmares, nausea, and vomiting, were also recorded.Results: The incidence of emergency agitation was lower in the esketamine group compared with that in the control group (5% vs. 27.5%, p = 0.006). The time to eye opening was longer in the esketamine group than in the control group (17.2 ± 2.7 vs. 15.5 ± 2.3 min, p = 0.005). However, the extubation time and time to discharge from PACU were similar between the two groups.Conclusion: Low-dose of esketamine decreases the incidence of emergency agitation in children after tonsillectomy without delaying extubation time and increasing the postoperative side effects. (www.chictr.org.cn, registration number: ChiCTR2100054178).
Images of bodies in mass and social media and body dissatisfaction: The role of internalization and self-discrepancy
Authors: Möri Michelle , Mongillo Federica , Fahr Andreas 
Published: December 2022

IntroductionThe study examines the influence on body dissatisfaction of viewed images of bodies transmitted over mass media and social media, as mediated by the internalization of body ideals through media and self-discrepancy (the difference between the perceived actual self and the perceived ideal self).MethodIn this study, the images of bodies individuals view in their everyday media diet are estimated using a newly developed pictorial scale for women (thinness) and men (muscularity). For participants, the perceived body image is formed through mass media (magazines, TV) and social media (Facebook, YouTube, Instagram, and Snapchat). The self-discrepancy theory is then used to explain the effect of images of bodies in the media on the internalization of these body ideals and body dissatisfaction.ResultsResults show that Facebook and YouTube shape body ideals perceived to be prevalent in the media, negatively influencing internalization and self-discrepancy. Self-discrepancy, in turn, increases body dissatisfaction. However, for males, the perceived body ideals in the media did not affect body dissatisfaction, internalization, or self-discrepancy.DiscussionThese results emphasize the importance of combining and comparing mass and social media and differentiating between female and male concerns regarding body image.
Retrospective study on bovine clinical mastitis and associated milk loss during the month of its peak occurrence at the National Dairy Farm in the Emirate of Abu Dhabi, United Arab Emirates
Authors: Ameni Gobena , Bayissa Berecha , Zewude Aboma , Degefa Berhanu Adenew , Mohteshamuddin Khaja , Kalaiah Gopala , Alkalbani Meera Saeed , Eltahir Yassir Mohammed , Elfatih Hamad Mohamed , Tibbo Markos 
Published: December 2022

BackgroundCommercial dairy establishments are relatively young in the United Arab Emirates (UAE), and as a result, there is lack of epidemiological data on mastitis in dairy farms.MethodsA retrospective data of seven years (2015–2021) were used to estimate the cumulative average monthly incidence rate of bovine clinical mastitis and evaluate associated milk loss at the National Dairy Farm. Data were extracted from the records of lactating dairy cows (n = 1300–1450) and analyzed using repeated measure and one-way ANOVA, non-parametric Spearman correlation, paired and unpaired t tests.ResultsThe highest average cumulative monthly incidence rate was 49 cases per 1000 cows-year that was recorded in 2019 while the lowest was 19 cases per 1000 cows-year in 2021. The cumulative average monthly incidence rate of clinical mastitis significantly (p &lt; 0.001) varied among the seven years. The cumulative average monthly incidence rate was associated with average monthly humidity (p &lt; 0.01) and average monthly rainfall (p &lt; 0.05); however, it was not associated with the average monthly temperature (p &gt; 0.05). The average daily milk yield of cows with clinical mastitis (Mean ± SEM; 18.6 ± 0.54 kg) was significantly (p &lt; 0.001) lower than the average daily milk yield of clinical mastitis free cows (40.5 ± 0.29 kg). The largest average monthly milk loss due to clinical mastitis was 5% of the average total monthly milk production in 2019 while the lowest was 2% of the average total monthly milk production in 2021.ConclusionThe result of the study indicated the direct influence of weather conditions such as increased rainfall and humidity, which caused an upsurge in the incidence rate of clinical mastitis, leading to an increased loss in milk and hence the economy of the dairy farm. Proactive preventive measures along with good dairy farm practices that help mitigate the impacts of harsh weather conditions are recommended.
Nitrogen Acquisition and Transport in the Ectomycorrhizal Symbiosis—Insights from the Interaction between an Oak Tree and Pisolithus tinctorius
Authors: Sebastiana Mónica , Serrazina Susana , Monteiro Filipa , Wipf Daniel , Fromentin Jérome , Teixeira Rita , Malhó Rui , Courty Pierre-Emmanuel 
Published: December 2022

In temperate forests, the roots of various tree species are colonized by ectomycorrhizal fungi, which have a key role in the nitrogen nutrition of their hosts. However, not much is known about the molecular mechanisms related to nitrogen metabolism in ectomycorrhizal plants. This study aimed to evaluate the nitrogen metabolic response of oak plants when inoculated with the ectomycorrhizal fungus Pisolithus tinctorius. The expression of candidate genes encoding proteins involved in nitrogen uptake and assimilation was investigated in ectomycorrhizal roots. We found that three oak ammonium transporters were over-expressed in root tissues after inoculation, while the expression of amino acid transporters was not modified, suggesting that inorganic nitrogen is the main form of nitrogen transferred by the symbiotic fungus into the roots of the host plant. Analysis by heterologous complementation of a yeast mutant defective in ammonium uptake and GFP subcellular protein localization clearly confirmed that two of these genes encode functional ammonium transporters. Structural similarities between the proteins encoded by these ectomycorrhizal upregulated ammonium transporters, and a well-characterized ammonium transporter from E. coli, suggest a similar transport mechanism, involving deprotonation of NH4+, followed by diffusion of uncharged NH3 into the cytosol. This view is supported by the lack of induction of NH4+ detoxifying mechanisms, such as the GS/GOGAT pathway, in the oak mycorrhizal roots.
The Effect of Yoga on the Intensity of Primary Dysmenorrhea in Adolescent Girls at Insan Permai Youth Posyandu Cikancung Village Bandung
Authors: Cahyati Nanik , Nurhayati Fitri , Sumarlina Nenden 
Published: December 2022

Dysmenorrhea is pain during menstruation that interferes with the daily activities of adolescent girls such as decreased concentration on learning because of the pain felt. One way to reduce the intensity of dysmenorrhea is with yoga. Therefore, it is necessary to prove the effect of yoga on dysmenorrhea intensity. The general purpose of this study was to determine the effect of yoga on the intensity of dysmenorrhea in adolescent girls at the Insan Permai Youth Posyandu, Cikancung Village. While the specific purpose is to identify the dysmenorrhea intensity score before and after yoga and analyze the effect of yoga in reducing dysmenorrhea in adolescent girls at the Insan Permai Youth Posyandu, Cikancung Village, Bandung Regency. This research design is a quantitative analytic pre-experiment with a one group pretest-posttest design approach and calculated using the paired t-test. The sample in this study amounted to 25 adolescent girls with data collection tools in the form of NRS (Numeric Rating Scale) observation sheets. The results of the study obtained a dysmenorrhea intensity scale before yoga with a mean of 4.32 and a dysmenorrhea intensity scale after yoga with a mean of 2.08 and p-value <0.05. This means that there is an effect of yoga in reducing dysmenorrhea in adolescent girls. This research is expected to be a reference for young women in reducing dysmenorrhea and midwives can also provide promotion that yoga is an alternative way to overcome dysmenorrhea.
The Effectiveness of a Counseling Program Based on the Mindfulness Approaches in Increasing the Psychological Well-Being among a Sample of Working Women at Al-Hassan Industrial Zone
Authors: Bany Ersheed Esra , Al-Shreffen Ahmad , Al-Refaei Abeer 
Published: December 2022

Objectives: The study aimed to discover the effectiveness of mindfulness therapy in enhancing the level of psychological well-being among a sample of working women in Al-Hassan Industrial zone in Irbid. The study sample consisted of 30 women working in al-Hassan Industrial zone. they were randomly assigned to two equal groups: the experimental group and control group.
Methods: To achieve the objectives of the study, the Psychological Well-Being Scale was used, in addition to a counseling program based on mindfulness approach. This study used psychological well-being as a dependent variable and a descriptive-analytical approach was also used to analyze the data elicited from female students and women. It also relied on mindfulness approach as an independent variable, and also relied on the semi-experimental approach in revealing the impact of mindfulness on some variables for working women and students.
Results: The results showed that there were statistically significant differences at the level of significance (α=0.05) between the two means of the pre and post measurement of the level of psychological well-being according to the group in the post-test in favor of the experimental group, Also, the results of the following up exam comparisons among the members of the experimental group indicated that there were no statistically significant differences for the (T) test for the correlated samples of the psychological well-being Scale and its dimensions.
Conclusions: Depending on the results, it becomes clear that the counseling program were effective.
The Role of Family Environment in Social Networking Sites Addiction among University Students
Authors: Bani-Hamad Abeer O. , Jaradat Abdul-Kareem M. 
Published: December 2022

Objectives: This study aimed to explore the differences in family environment of students who are addicted to social networking sites, and those who are not. Additionally, the study aimed to investigate the contribution of family environment to Social Networking Sites Addiction (SNSA) among Jordanian university students.
Methods: The sample of the study consisted of 629 undergraduate students. Data were collected online, using two scales for measuring family environment and SNSA. The study utilized the descriptive-predictive method by distributing a questionnaire to the study participants via google forms.
Results: Results revealed significant differences in the mean scores of students addicted to social networking sites, and those who were not on the subscales of the family environment scale, where students who were not addicted scored higher on the subscales of cohesion, expressiveness and organization, whereas addicted students scored higher on the conflict subscale. It was found that the dimensions of conflict, intellectual-cultural orientation and expressiveness of the family environment scale predicted SNSA in males; and the dimensions of conflict and expressiveness predicted SNSA in females.
Conclusions: The level of addiction to social networking sites among university students is determined according to the family environment in which they live. If the family environment is characterized by cohesion and gives children freedom of expression and encourages organization, then the children will not resort to social networking sites as a means to escape from the conditions in which they live; and on the contrary if the environment is dominated by ongoing conflicts between family members.
The Influence of Narrative Method through Employing Enrichment, Interactive, Multimedia Materials on the Enhancement of Reading Comprehension Skills in Arabic Language among Second Grade Students
Authors: Al-Saraj Rowaida Harbi Mohammad , Dyab Hamadneh Adeeb 
Published: December 2022

Objectives:The current study is to investigate the effect the storytelling method by employing Arabic among students of the second garde using the quasi-experimental approach and interactive multimedia enrichment materials were formed in developing reading comprehension skills in language.
Methods: The study sample consisted of (62) students from jabal Prince Faisal Basic School. The sample was divided randomalu into two groups, one of which is experimental and included (31) male and female students and the other is a control and it had (31) male and female students.
The study was applied in the first semester of the academic year 2020/2021 and the study tool was prepared from it by examining the literal comprehension of the realable and in its final form of (10) paragraphs, and it was applied after verification of validity and consistency.
Results: The result of the study indicated that there were statistically significant differences in the arithmetic averages and orbital deviations of the students, performance on the test of the literal comprehension of the post- reading in favor of the experimental group that studied using the method of storytelling by employing the media and light of these results.
Conclusions: The study recommended the necessity of employing multimedia And storytelling to restore the Arabic language.
The Relative Contribution of Resilience and Social Support to Family Quality of Life of a Sample of Mothers of Children with Autism Spectrum Disorder in Qatar
Authors: Hassanein Elsayed Elshabrawi A. , Adawi Taha Rabie T. , Al-Attiyah Asma Abdullah , Elsayad Walid Atef Mansour 
Published: December 2022

Objectives: The current research aims to explore the family quality of life, resilience and social support of mothers of children with autism spectrum disorder in Qatar. Additionally, it aims to investigate the relationship between the family quality of life, resilience and social support, and the possibility of predicting the family quality of life through resilience and social support.
Methods: The current research utilizes the descriptive approach on the research sample consisted of (220) mothers of children with autism spectrum disorder. Three tools were utilized in this research. They are Family quality of life scale, Brief Resilience scale, and 2-Way Social Support Scale.
Results: The results showed that the participants obtained a high level on most aspects of family quality of life and social support, while they obtained a medium level in resilience. The results of the current research also revealed a positive relationship between family quality of life and both resilience social and support, and the possibility of predicting family quality of life through social support.
Conclusions: The current study concluded that social support and resilience are of great importance in enhancing the quality of family life.