bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug‐Coated Balloon and Drug‐Eluting Stent Safety in Patients With Femoropopliteal and Severe Chronic Kidney Disease
Authors: Hanna Jonathan , Smolderen Kim G. , Castro‐Dominguez Yulanka , Romain Gaëlle , Lee Megan , Turner Jeffrey , Mena‐Hurtado Carlos 
Published: March 2023

Background
Patients with severe‐stage chronic kidney disease (CKD) were excluded from femoropopliteal disease trials evaluating drug‐coated balloons (DCBs) and drug‐eluting stents (DESs) versus plain balloon angioplasty (POBA) and bare metal stents (BMSs). We examined the interaction between CKD status and device type for the association with 24‐month all‐cause mortality and major amputation risk.

Methods and Results

We studied patients undergoing femoropopliteal interventions (September 2016–December 2018) from Medicare‐linked VQI (Vascular Quality Initiative) registry data. We compared outcomes for: (1) early‐stage CKD (stages 1–3) receiving DCB/DES, (2) early‐stage CKD receiving POBA/BMS, (3) severe‐stage (4 and 5) CKD receiving DCB/DES, and (4) severe‐stage CKD receiving POBA/BMS. We studied 8799 patients (early‐stage CKD: 94%; severe‐stage: 6%). DCB/DES use was 57% versus 51% in patients with early‐stage versus severe‐stage CKD. Twenty‐four‐month mortality risk for patients with early‐stage CKD receiving DCB/DES (reference) was 21% versus 28% (hazard ratio [HR], 1.47 [95% CI, 1.31–1.65]) for those receiving POBA/BMS; patients with severe‐stage CKD: those receiving DCB/DES had a 49% (HR, 2.61 [95% CI, 2.06–3.31]) mortality risk versus 52% (HR, 3.64 [95% CI, 2.91–4.55]) for those receiving POBA/BMS (interaction
P
<0.001). Adjusted analyses attenuated these results. For severe‐stage CKD, DCB/DES versus POBA/BMS mortality risk was not significant at 24 months (post hoc comparison
P
=0.06) but was higher for the POBA/BMS group at 18 months (post hoc
P
<0.05). Patients with early‐stage CKD receiving DCB/DES had the lowest 24‐month amputation risk (6%), followed by 11% for early‐stage CKD‐POBA/BMS, 15% for severe‐stage CKD‐DCB/DES, and 16% for severe‐stage CKD‐POBA/BMS (interaction
P
<0.001). DCB/DES versus POBA/BMS amputation rates in patients with severe‐stage CKD did not differ (post hoc
P
=0.820).

Conclusions
DCB/DES versus POBA/BMS use in patients with severe‐stage CKD was associated with lower mortality and no difference in amputation outcomes.
GABAergic Involvement in Selective Attention
Authors: Faßbender Kaja , Baumert Philine M. , Wintergerst Maximilian W. M. , Terheyden Jan H. , Aslan Behrem , M. Harmening Wolf , Ettinger Ulrich 
Published: March 2023

AbstractAnimals need to cope with abundant sensory information, and one strategy is to selectively direct attention to only the most relevant part of the environment. Although the cortical networks of selective attention have been studied extensively, its underlying neurotransmitter systems, especially the role of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), remain less well understood. Increased GABAA receptor activity because of administration of benzodiazepines such as lorazepam is known to slow reactions in cognitive tasks. However, there is limited knowledge about GABAergic involvement in selective attention. Particularly, it is unknown whether increased GABAA receptor activity slows the build-up of selectivity or generally widens attentional focus. To address this question, participants (n = 29) received 1 mg lorazepam and placebo (within-subjects, double-blind) and performed an extended version of the flanker task. The spatial distribution of selective attention was studied by systematically manipulating number and position of incongruent flankers; the temporal build-up was characterized using delta plots. An online task version was presented to an independent, unmedicated sample (n = 25) to verify task effects. Under placebo and in the unmedicated sample, only the number of incongruent flankers, but not their position, influenced RTs. Incongruent flankers impaired RTs more strongly under lorazepam than placebo, especially when adjacent to the target. Delta plot analyses of RT showed that this effect persisted even when participants reacted slowly, indicating that lorazepam-induced impairments in selective attention do not result from simply slowed down build-up of selectivity. Instead, our data indicate that increased GABAA receptor activity widens the attentional focus.
Domain-Specific Word Embeddings with Structure Prediction
Authors: Lassner David , Brandl Stephanie , Baillot Anne , Nakajima Shinichi 
Published: March 2023

Abstract
Complementary to finding good general word embeddings, an important question for representation learning is to find dynamic word embeddings, for example, across time or domain. Current methods do not offer a way to use or predict information on structure between sub-corpora, time or domain and dynamic embeddings can only be compared after post-alignment. We propose novel word embedding methods that provide general word representations for the whole corpus, domain- specific representations for each sub-corpus, sub-corpus structure, and embedding alignment simultaneously. We present an empirical evaluation on New York Times articles and two English Wikipedia datasets with articles on science and philosophy. Our method, called Word2Vec with Structure Prediction (W2VPred), provides better performance than baselines in terms of the general analogy tests, domain-specific analogy tests, and multiple specific word embedding evaluations as well as structure prediction performance when no structure is given a priori. As a use case in the field of Digital Humanities we demonstrate how to raise novel research questions for high literature from the German Text Archive.
Why Does Surprisal From Larger Transformer-Based Language Models Provide a Poorer Fit to Human Reading Times?
Authors: Oh Byung-Doh , Schuler William 
Published: March 2023

AbstractThis work presents a linguistic analysis into why larger Transformer-based pre-trained language models with more parameters and lower perplexity nonetheless yield surprisal estimates that are less predictive of human reading times. First, regression analyses show a strictly monotonic, positive log-linear relationship between perplexity and fit to reading times for the more recently released five GPT-Neo variants and eight OPT variants on two separate datasets, replicating earlier results limited to just GPT-2 (Oh et al., 2022). Subsequently, analysis of residual errors reveals a systematic deviation of the larger variants, such as underpredicting reading times of named entities and making compensatory overpredictions for reading times of function words such as modals and conjunctions. These results suggest that the propensity of larger Transformer-based models to ‘memorize’ sequences during training makes their surprisal estimates diverge from humanlike expectations, which warrants caution in using pre-trained language models to study human language processing.
The Planning Daemon: Future Desire and Communal Production
Authors: Grünberg Max 
Published: March 2023

Abstract
Within the planning discourse two poles have materialised over the last decades: a participatory ideal guided by substantive rationality, opposed to an algorithmic governmentality subordinated to instrumental reason. This rift within socialist thought is also observable when it comes to the discovery of needs. The paper understands this discovery procedure primarily as a forecasting problem and demonstrates how many authors dedicated to a participatory planning process call for consumers to write down their desires in the form of wish lists. As a response to this epistemically questionable discovery procedure, the state of the art in capitalist demand-forecasting at enterprises like Amazon is presented, where machine-learning algorithms excel at modelling interrelated time series on a global level by extrapolating demand patterns in real-time. The paper closes with a proposal to reconfigure this predictive apparatus for socialist ends and raises questions concerned with the political implications of centralising decision-making in black-box algorithms.
Rethinking Political Inclusion Beyond Moderation: Strategic Relational Pluralization in Tunisian Islamist Politics
Authors: Gana Alia , Sigillò Ester , Blanc Théo 
Published: March 2023

Abstract
This article explores the complex dynamics shaping the integration of the Tunisian Islamist party Ennahdha into the instituted political game. Drawing on a strategic relational approach, the analysis highlights the simultaneous, mutually reactive, and often conflicting relationships of Ennahdha party with three types of actors: political secular forces (allied or antagonist), political and religious Salafi actors, and faith-based associations. Based on extensive field research and 33 in-depth interviews conducted with key players involved, we propose to capture these dynamics at the macro (regime), meso (organizations), and micro levels, through the notion of strategic pluralization, by which we mean a reconfiguration of Ennahdha’s relations with various Islamic actors under the pressure of secular forces. Going beyond institutional-structural approaches and monolithic interpretations of the Islamist constellation, we argue that Ennahdha’s integration in relational economies has formed the basis of the party’s strategy to secure its political inclusion in the post-revolutionary scene.
‘The Zeal with which Christ was Inflamed’: The Irascible Power and Clerical Authority in the Writing of Pope Innocent III (r. 1198–1216)
Authors: Day Kirsty 
Published: March 2023

Abstract
The writing of Pope Innocent III (r. 1198–1216) contains multiple references to the irascible power of the human soul, the purpose of which was to repel evil. In Si dormiatis, Innocent’s sermon on the ideal priesthood, the violent emotional behaviour produced by the irascible power is proof that the priest was carrying out his office correctly. Analysis of the sermon in the context of Innocent’s own corpus, contemporary commentaries on ‘angry emotions’, and the intense period of ecclesiastical reform in which Innocent was writing reveals that Innocent intended this aggressive response to instantiate correct order, shore up clerical and papal authority over the spiritual, and protect this authority as the exclusive preserve of men.
Disparity in Educational Participation in the Lenses of Educational Returns and Family Background: Evidence from India
Authors: Ray Chaudhury Anjan , Sarkar Sreemanta , Sinha Madhabendra 
Published: March 2023

The paper attempts to investigate the origin of inequality in educational participation across Indian social groups in terms of inequality in the expected monetary educational returns and other demand-side factors responsible behind educational decision. We employ the binary logit model of regression for the accomplishment of the objective of this study. In addition, we decompose the discrepancy in educational participation into ‘response effect’ and ‘attribute effect’ to examine whether there is any discrimination in educational participation against the members of the disadvantaged social groups. JEL Classification: I21, I24, I26
Prevalence of Treatment of Early Childhood Caries among Children with Cleft Lip and/or Cleft Palate in Manitoba
Authors: Surtie Fareea , Ebadi Mohammadhassan , Klus Bradley A. , Schroth Robert J 
Published: March 2023

Objective To determine the prevalence of treatment of early childhood caries (ECC) using general anesthesia (GA) in children with cleft lip and/or palate (CL/P). Design Retrospective chart review of children followed by the Manitoba Cleft Lip and Palate Program (MCLPP) to determine the frequency of treatment for ECC under GA. Setting Children's Hospital, Winnipeg, Canada (a tertiary care centre). Patients Children registered with MCLPP between January 1, 2008- December 31, 2019. Interventions The chart review collected data on the following variables: sex, date of birth, postal code, type of cleft, whether child had treatment of ECC using GA, age at the time of GA, and cost of treatment. Main outcome measures Association of CL/P with ECC. Results Overall, 441 children had CL/P. 17% had isolated cleft lip (CL), 46% had isolated cleft palate (CP), and 37% had both cleft lip and palate (CLP). Overall, 24.3% of children with CL/P underwent dental surgery using GA while 14.5% underwent dental surgery to treat ECC between 12-59 months of age. When compared to a reference of Canadian healthy children 12-59 months of age, a child with CL/P was 15 times more likely to require GA to treat ECC. Conclusion Treatment for caries under GA in children with CL/P is common. In the children with CL/P the rates of GA for treatment of ECC are significantly higher when compared to the general population. Children with CL/P require comprehensive oral health prevention to reduce the risk for caries and the need for treatment under GA.
Mechanical Evaluation of Commercially Available Fibrin Sealants for Cartilage Repair
Authors: Amirhekmat Arya , Brown Wendy E. , Salinas Evelia Y. , Hu Jerry C. , Athanasiou Kyriacos A. , Wang Dean 
Published: March 2023

Objective Fibrin sealants are routinely used for intra-articular surgical fixation of cartilage fragments and implants. However, the mechanical properties of fibrin sealants in the context of cartilage repair are unknown. The purpose of this study was to characterize the adhesive and frictional properties of fibrin sealants using an ex vivo model. Design Native bovine cartilage-bone composites were assembled with a single application of Tisseel or Vistaseal. Composites were tested in tension and lap shear. In addition, the coefficient of friction (COF) was measured in a native cartilage annulus model alone and with minced cartilage. Finally, the effect of a double application of fibrin sealant was evaluated. Results There were no significant differences in tensile modulus, ultimate tensile strength (UTS), shear modulus, or ultimate shear strength (USS) between the 2 fibrin sealants. Both fibrin sealants demonstrated a UTS and USS of <8 and <30 kPa, respectively. There were no differences in COF between the sealants when tested alone or with minced cartilage. A double application of fibrin sealant did not alter the mechanical properties compared with a single application of fibrin sealant. Conclusions Fibrin sealant adhesive properties are not affected by the sealant type studied or the number of applications in a bovine cartilage-bone model. Fibrin sealant tribological properties are not affected by sealant type or the addition of minced cartilage. The adhesive properties of Tisseel and Vistaseal were less than those desired for the in vivo fixation of cartilage repair implants. These findings motivate the development of an improved cartilage-specific adhesive for cartilage repair applications.
Local Intraoperative Marrow-Derived Augmentation for Primary Rotator Cuff Repair: An Updated Systematic Review and Meta-analysis of Studies From 2010 to 2022
Authors: Le Breton Stephen , Forlizzi Julianne , Bono Olivia , MacAskill Meghan , Mousad Albert , Kush Sophie , O’Brien Makenzie , Christensen Alaia , Mithoefer Kai , Ramappa Arun , Ross Glen , Shah Sarav S. 
Published: March 2023

Background: Recurrent tears of the rotator cuff pose a substantial problem despite advances in repair technique. Biologic augmentation via marrow stimulation or vented anchors may strengthen the suture-tendon junction and improve healing rates of native tissue, thereby enhancing outcomes of primary surgical repair. Purpose: To provide a focused systematic review and meta-analysis of local, intraoperative marrow-derived augmentation techniques in clinical primary rotator cuff repair. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of PubMed, Embase, and Cochrane was conducted following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. A total of 2131 studies from 2010 to 2022, focused on either marrow stimulation or vented anchors, were isolated and classified as either preclinical or clinical. Meta-analysis was performed for comparative marrow stimulation and vented anchor studies. Heterogeneity was tested through calculation of I 2. Results: A total of 13 clinical studies were included in the review. All 9 comparative studies included in the meta-analysis demonstrated high methodologic quality or a low risk of bias. The pooled retear rate across all 9 clinical studies for patients undergoing marrow stimulation was 11%. For the 5 studies in the meta-analysis, the pooled retear rates were 15% for marrow stimulation and 30% for controls. Meta-analysis demonstrated a significant difference in the overall retear rate that favored marrow stimulation (odds ratio [OR], 0.41; 95% CI, 0.25-0.66; P = .0003; I 2 = 0%). Similarly, meta-analysis of the Constant score at final follow-up demonstrated a statistically significant difference between the 2 groups that favored a higher Constant score in the marrow stimulation group (mean difference, 2.84; 95% CI, 1.02-4.66; P = .002; I 2 = 29%). Vented anchors demonstrated improved ossification and bone density at the anchor site, but no difference in outcomes or retear. Pooled retear rates were 22.5% for vented anchors and 27.8% for controls. Conclusion: Current evidence demonstrates that marrow-stimulation techniques may have a positive impact on healing and retear rate, while vented anchors have a muted impact relative to nonvented anchors. Although available evidence is limited and more research is needed, findings to date suggest that marrow stimulation techniques may be an inexpensive, straightforward technique to consider in qualifying patients to prevent rotator cuff retears.
Lateral Extra-Articular Tenodesis via an All-Suture Anchor
Authors: Dulas Matthew , Vinod Amrit V , Athiviraham Aravind 
Published: March 2023

Background: In young patients, anterior cruciate ligament (ACL) reconstruction often results in graft failure. This may be due, in part, to concomitant injury to anterolateral complex (ALC) of the knee leading to rotatory laxity. The modified Lemaire lateral extra-articular tenodesis (LET) technique is intended to address the anterolateral rotatory instability due to injury to the ALC and to protect the ACL graft and meniscus. Indications: The International Anterolateral Complex Consensus Group Meeting identified 4 appropriate indications for the modified Lemaire LET procedure: revision ACL, high-grade pivot shift, generalized ligamentous laxity/genu recurvatum, and young patients returning to pivoting activities. Technique Description: The technique consists of harvesting an 8-cm long by 1-cm wide graft from the iliotibial band. The graft is released proximally and remains attached distally to Gerdy’s tubercle. The graft is then passed deep to the lateral collateral ligament (LCL) from distal to proximal. The graft is then affixed to a point proximal and posterior to the lateral femoral epicondyle with an all-suture button. The graft is then tensioned with knee at 30° of flexion and neutral rotation, and then secured in place. Results: With the modified Lemaire LET, there was previously concern for overconstraint and lateral compartment degeneration. However, recent studies have shown that there is no increased risk for these complications with the LET procedure. The STABILITY trial found that the addition of LET to ACL reconstruction significantly reduces re-rupture and residual laxity when compared with ACL reconstruction alone. Moreover, the addition of LET to ACL reconstruction can restore native knee kinematics. Conclusion: The addition of the modified Lemaire LET technique to traditional ACL reconstruction is a safe and effective adjunct that reduces the occurrence of graft rupture, addresses residual rotational laxity, and can restore native knee kinematics in appropriately indicated patient populations. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.
Effect of interactive, multimedia-based home-initiated education on preoperative anxiety inchildren and their parents: a single-center randomized controlled trial
Authors: Hou Huiyan , Li Xie , Song Yun’an , Ji Yingying , Sun Menglian , Wang Dan , Jiao Jiali , Qu Jifang , Gu Hongbin 
Published: March 2023

AbstractBackgroundAnesthesiologists need to appreciate the impact of preoperative anxiety in children. The present study aimed to explore whether interactive multimedia-based home-initiated interventions could effectively relieve preoperative anxiety in pediatric patients.MethodsIn this prospective study, we compared preoperative anxiety between two groups of children aged 4–9 years. Children in the control group received a question-and-answer (Q&A) introduction, and children in the intervention group received multimedia-based home-initiated preoperative education using comic booklets, videos, and coloring game books. Differences in anxiety between the two groups were evaluated by the modified Yale Preoperative Anxiety Scale-Short Form (mYPAS-SF) at four time points: in the ophthalmology outpatient clinic before intervention as the baseline (T0); in the preoperative waiting area (T1); at the time of separating from their parents and moving to the operating room (T2); and at the time of anesthesia induction (T3). Parental anxiety was assessed by the Self-rating Anxiety Scale (SAS) and Visual Analog Scale (VAS) at T0 and T2. Other related information was collected by questionnaire.ResultsEighty-four children who underwent pediatric strabismus in our center between November 2020 and July 2021 were included in this study. An intention-to-treat (ITT) analysis was performed on data from 78 enrolled children. Children in the intervention group exhibited lower m-YPAS-SF scores at T1, T2, and T3 than those in the control group (all p < 0.001). By using a mixed-effect model with repeated measurement (MMRM) after adjusting the m-YPAS score at T0 as a covariate, the interventional effect in terms of themYPAS-SF score was also significant over time (p < 0.001). The percentage of children with perfect induction compliance (ICC = 0) in the intervention group was significantly higher than that in the control group [18.4% vs. 7.5%], and poor induction compliance (ICC>4) was lower (2.6% vs. 17.5%, p = 0.048). The mean parental VAS score at T2 in the intervention group was significantly lower than that in the control group (p = 0.021).ConclusionsInteractive multimedia-based home-initiated intervention could reduce preoperative anxiety in children and improve the quality of anesthesia induction based on ICC scores, which may in turn impose a positive impact on parental anxiety.