bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional social support and cognitive function in middle- and older-aged adults: A systematic review of cross-sectional and cohort studies
Authors: Mogic Lana , Rutter Emily C , Tyas Suzanne L , Maxwell Colleen J , O’Connell Megan E , Oremus Mark 
Published: February 2023

Abstract
Background

Intact cognitive function is crucial for healthy aging. Functional social support is thought to protect against cognitive decline. We conducted a systematic review to investigate the association between functional social support and cognitive function in middle- and older-aged adults.

Methods

Articles were obtained from PubMed, PsycINFO, Sociological Abstracts, CINAHL and Scopus. Eligible articles considered any form of functional social support and cognitive outcome. We narratively synthesized extracted data by following the Synthesis Without Meta-Analysis (SWiM) guidelines and assessed risk of bias using the Newcastle-Ottawa Scale (NOS).

Results

Eighty-five articles with mostly low risk-of-bias were included in the review. In general, functional social support—particularly overall and emotional support—was positively associated with cognitive function in middle- and older-aged adults. However, these associations were not all statistically significant. Substantial heterogeneity existed in the types of exposures and outcomes evaluated in the articles, as well as in the specific tools used to measure exposures and outcomes.

Conclusions

Our review highlights the role of functional social support in the preservation of healthy cognition in aging populations. This finding underscores the importance of maintaining substantive social connections in middle and later life.

Systematic review registration

Rutter EC, Tyas SL, Maxwell CJ, Law J, O'Connell ME, Konnert CA, Oremus M. Association between functional social support and cognitive function in middle-aged and older adults: a protocol for a systematic review. BMJ Open;10(4):e037301. doi: 10.1136/bmjopen-2020-037301
Ab Initio Study of the Complexes of Aspartic Acid and n Molecules of Water, n = 1 and 2, Formed by Hydrogen Bonds
Authors: DE LIMA AMANDA MARQUES , FRAZÃO NILTON FERREIRA , VELARDEZ GUSTAVO FABIAN 
Published: February 2023

Abstract
Hydrogen bonds (HB) influence the conformational preferences of biomolecules and their optical and electronic properties. The objective of this work is to study some structures and the S1← S0 electronic transitions of aspartic acid (ASP) and complexes formed by HB between ASP-(H2O)1,2 in the gas phase. To do this, the DFT and TD-DFT methods were used, using the B3LYP functional with six different basis sets. Interactions between the carboxylic groups of ASP with water molecules, forming cyclic structures with two HB, resulted in more stable and less polar complexes, than other conformers with formed HB between water and the NH2 group. It was observed that there is a relationship between the deviation in the UV-Vis absorption band of the ASP and the stabilization/destabilization of the S1 state to the S0 of the complexes. The electrostatic destabilization of the S1 state and interactions of water with the HOMO orbital caused a blueshift in the ASP absorption band, while the electrostatic stabilization of the S1 state and interactions with the LUMO caused a redshift. But in some cases, as it was observed on 1:1 complex ASP-W2, this analysis may not be precise due to the small change in ΔE.
The impacts of sarcopenia on outcomes of patients with left-sided colon or rectal cancer after curative surgery
Authors: Li Qi , An Tailai , Wu Jianbin , Lu Weiqi , Wang Yan , Li Jia , Yang Lina , Chen Yiqi , Lin Lizhu , Yang Zhenjiang 
Published: February 2023

Abstract
Background
The impacts of nutritional status on and short-term and long-term survival of patients with left-sided colon or rectal cancer have not been exhaustively investigated. Thus, we accomplished the present study to evaluate the effects of sarcopenia on short-term and long-term outcomes of patients with left-sided colon or rectal cancer.
Methods
Patients with pathologically diagnosed stage I, II and III left-sided colon or rectal cancer who had undergone curative surgery were studied. The psoas muscle index (PMI) identified by 3D-image analysis of computed tomographic images was the criterion used to diagnose sarcopenia. The cutoff value recommended by Hamaguchi et al. (PMI value < 6.36 cm2/m2 for men and < 3.92 cm2/m2 for women) was adopted to confirm the diagnosis of sarcopenia. According to PMI, each patient was divided into the sarcopenia group (SG) or the non-sarcopenia group (NSG). Then SG was compared with NSG in terms of short-term outcomes and long-term outcomes.
Results
Among the 939 patients included, 574 ones (61.1%) were confirmed with preoperative sarcopenia. Initially, it was demonstrated that SG was not significantly different from NSG in terms of most baseline characteristics except smaller body mass index (BMI) (P < 0.001), larger tumor size (P < 0.001) and more weight loss (P = 0.029). Then it revealed that SG had a longer hospital stay after surgery (P = 0.040), more intraoperative blood transfusion (P = 0.035), and a higher incidence of anastomotic fistula (P = 0.027), incision infection (P = 0.037) and hypoalbuminemia (P = 0.022). The SG had significantly worse overall survival (OS) (P = 0.016) and recurrence-free survival (RFS) (P = 0.036) than the NSG. Subsequently, by Cox regression analysis, we revealed that preoperative sarcopenia was an independent predictive factor for worse OS (P = 0.0211, HR = 1.367, 95%CI: 1.049–1.782) and RFS (P = 0.045, HR = 1.299, 95%CI: 1.006–1.677).
Conclusion
Preoperative sarcopenia significantly adversely affected long-term and short-term outcomes of patients with left-sided colon or rectal cancer and preoperative nutrition supplementation may help us improve their long-term and short-term outcomes.
Opto-E-cadherin: Optogenetic control over cell-cell adhesions
Authors: Mombo Brice Nzigou , Bijonowski Brent , Niland Stephan , Brockhaus Katrin , Müller Marc , Eble Johannes , Wegner Seraphine 
Published: February 2023

Abstract
E-cadherin-based cell-cell adhesions are dynamically and locally regulated in many essential processes, including embryogenesis, wound healing and tissue organization, with dysregulation manifesting as tumorigenesis and metastasis. However, the lack of tools that would provide control of the high spatiotemporal precision observed with E-cadherin adhesions hampers investigation of the underlying mechanisms. Here, we present an optogenetic tool, opto-E-cadherin, that allows reversible control of E-cadherin-mediated cell-cell adhesions with blue light. With opto-E-cadherin, functionally essential calcium binding is photoregulated such that cells expressing opto-E-cadherin at their surface adhere to each other in the dark but not upon illumination. Consequently, opto-E-cadherin provides remote control over multicellular aggregation, E-cadherin-associated intracellular signalling and F-actin organization in 2D and 3D cell cultures. Opto-E-cadherin also allows switching of multicellular behaviour between single and collective cell migration, as well as of cell invasiveness in vitro and in vivo. Overall, opto-E-cadherin is a powerful optogenetic tool capable of controlling cell-cell adhesions at the molecular, cellular and behavioural level that opens up perspectives for the study of dynamics and spatiotemporal control of E-cadherin in biological processes.
Effect of Titanium-Dioxide nanoparticle on Richardson Constant and Barrier Height of Tartrazine Dye based Schottky Device
Authors: Karan Arnab Kanti , Sahoo Dipankar , Sen Sudipta , Rakshit Subhra , Manik Nabin Baran 
Published: February 2023

Abstract
Recently Fruit Dyes have achieved a significant interest as organic devices because of they are widely available, customizable and biodegradable. But low conductivity is one of the major limitations. Low conductivity is due to low charge injection from the electrodes to the organic layer and the charge injection process is strongly dependent on the injection barrier height at the metal-dye interface. Higher barrier height causes low charge injection. A detailed analysis is needed to reduce the interfacial barrier to get better conductivity. In this work, we have estimated the interfacial barrier height of Indium tin oxide coated glass/Tartrazine dye/Copper based device with and without titanium dioxide nanoparticles. The devices have been prepared with dye and dye-nanoparticles blends by using the spin coating technique. We have measured the steady state dark current-voltage-temperature characteristics in the range of 288 K to 333 K to estimate the Richardson constant and interfacial barrier height. The Richardson constant was found to be modified from 44.35×10-3 to 07.34×10-2 Am-2K-2. We also have found that interfacial barrier height is reduced from 0.71 eV to 0.64 eV in the presence of nanoparticles at room temperature. As the temperature increased, the interfacial barrier height increased to 0.72 eV from 0.71 eV and to 0.68 eV from 0.62 eV for dye based device with and without nanoparticles, respectively. Reduction of the interfacial barrier height indicates an increase in the charge injection through the interface. This work will be informative to improve the charge flow at the metal–fruit dye interface.
Development of Spectinabilin Over-Producing Mutant Streptomyces sp. S-N87 having Nematicidal Activities
Authors: Kang Min-Kyoung , Kim Jong-Hoon , Moon Kyung Ho , Jeong Hyeon Ji , Lee Byeong Min , Sung Bong Hyun , Park Dong-Jin , Son Kwang-Hee 
Published: February 2023

Abstract
Spectinabilin (neoaureothin) is a rare nitrophenyl-substituted polyketide produced by some Streptomyces species. This compound is known to exhibit various biological activities such as anticancer, antibiotic, immunomodulatory, antimalarial and nematicidal effects. Despite being a valuable secondary metabolite for the development of novel drugs, the production yield of spectinabilin is < 200 mg/litre at the current level. To improve the yields of this promising compound without biosafety and regulation issues, this study conducted traditional mutagenesis. A total of 1,025 mutants were generated under high mortality conditions by NTG (N-methyl-N’-nitro-N-nitrosoguanidine) from parental strain Streptomyces sp. AN091965. One of the mutants, S-N87 showed up to about 10-fold spectinabilin productivity (354.8 ± 7.8 mg/L) compared to the parental strain Streptomyces sp. AN091965 (37.6 ± 5.6 mg/L) in flask culture conditions, representing the highest spectinabilin yield reported thus far. In addition, this strain showed a stable yield of 2.27 g/L even in a scaled-up environment (150 L tank fermentation), which suggests that the selected mutant is a genetically stable and robust strain. Further, the mutant Streptomyces sp. S-N87 that enhanced spectinabilin production stably showed a significant increase in nematicidal activities against pine wilt nematode compared to the parental strain. The present study is the first to develop a Streptomyces mutant that over-produces spectinabilin by traditional mutagenesis. Further studies such as whole-genome analysis and genetic modification are needed to provide a theoretical basis and insights into the polyketide synthase pathway of this talented mutant.
Efficacy of tapering (STEP down) therapy using vonoprazan for symptomatic mild reflux esophagitis
Authors: Ochiai Yorinari , Kikuchi Daisuke , Hoteya Shu 
Published: February 2023

Abstract
Aim: This study aimed to elucidate the efficacy of tapering (STEP down) therapy based on patients’ symptoms using vonoprazan (VPZ) for symptomatic mild reflux esophagitis (RE).
Methods: Sixty-three consecutive symptomatic patients with mild RE were enrolled in this study. STEP down therapy was defined as a treatment period of 28 days. VPZ (20 mg) was administered as initial treatment. Patients were allowed to step down to 10 mg VPZ if their symptoms improved, and may discontinue VPZ if their symptoms disappeared. When symptoms worsened, dosage could be increased from 10 mg to 20 mg VPZ, or VPZ restarted at 20 mg following discontinuation.
Results: The proportion of the patients whose FSSG scores decreased by three points or more with STEP down therapy was 76.2% (48/63 patients). The median FSSG scores before and after STEP down therapy were 13 (8–35) and 7 (0–29) points, respectively (p<0.01). Overall, 71.4% (45/63) of patients stepped down from 20 mg to 10 mg VPZ, and 46% (29/63) of patients discontinued VPZ.
Conclusion: STEP down therapy with VPZ may be a viable treatment option in symptomatic patients
with mild RE.
Investigating the Sustainability of River Bank Filtration in Iraq
Authors: Ghanim Adnan D. , Eltoukhy Mahmoud A R. , El-Serafy Sonia Y. , Mohamed Elzahry F. 
Published: February 2023

AbstractIn the framework ofRiverBankFiltration "RBF" applicability to confront Iraq water crises, this investigation was originated with the impartial of investigating its sustainability in Iraq. Principally, literature was reviewed in the field of RBF sustainability. 2 previous research results of a sampling campaign in November 2021, were implemented; Adnan et al. (2022a) and (2022b). They verified RBF applicability against Iraqi Standards and validated its applicability against International Standards, respectively. Accordingly, in this research, extensive fieldwork was executed, where site visits were carried out along Tigris River; the available wells were inspected and 5 sampling campaigns were undergone periodically, in December 2021, March 2022, April 2022, July 2022 and August 2022. This was achieved to consider Iraq seasonality. The samples result of the 5 campaigns were analyzed; plotted on graphs and compared to the results of Adnan et al. (2022a). The analyzed results and comparison emphasized the sustainability of RBF applicability in Iraq, which would, most probably contribute in solving its water conflict crisis.
Transcatheter arterial embolization for acute lower gastrointestinal bleeding using imipenem/cilastatin: A single-center retrospective study
Authors: Hiraki Sakiko , Sato Fumie , Osugi Masaya , Watanabe Yoshiya , Ichinose Yoshiaki 
Published: February 2023

Abstract
Background: Transcatheter arterial embolization (TAE) is a standard treatment for acute lower gastrointestinal bleeding (LGIB) in situations where endoscopic approaches are impossible or ineffective. Various embolic materials, such as metallic coils and N-butyl cyanoacrylate, are used. This study aimed to evaluate the clinical outcomes of an imipenem/cilastatin (IPM/CS) mixture as an embolic agent in TAE for acute LGIB.
Results: Twelve patients (mean age, 67 years) with LGIB treated with TAE using IPM/CS were retrospectively evaluated between February 2014 and September 2022. All patients showed evidence of extravasation on computed tomography and 50% (6/12) also showed evidence on angiography. The technical success rate for TAE in this study was 100%, including in patients who showed active extravasation on angiography. The clinical success rate was 83.3% (10/12), with two patients experiencing re-bleeding within 24 h after the procedure. No ischemic complications were observed and no bleeding episodes or other complications were reported during the follow-up period.
Conclusions: This study revealed that using IPM/CS as an embolic agent in TAE for acute LGIB may be safe and effective, even in cases of active bleeding.
Genomic analysis and filtration of novel prognostic biomarkers based on metabolic and immune subtypes in pancreatic cancer
Authors: Chen Guangyu , Liu Yueze , Su Dan , Qiu Jiangdong , Long Junyu , Zhao Fangyu , Tao Jinxin , Yang Gang , Huang Hua , Xiao Jianchun , Zhang Taiping , Zhao Yupei 
Published: February 2023

Abstract
An increasing number of studies have indicated that patients with pancreatic cancer (PC) can be classified into various molecular subtypes and benefit from some precise therapy. Nevertheless, the interaction between metabolic and immune subtypes in the tumor microenvironment (TME) remains unknown. Thus, we utilized unsupervised consensus clustering and ssGSEA analysis respectively to construct molecular subtypes related to metabolism and immunity. Meanwhile, diverse metabolic and immune subtypes were characterized by distinct prognoses and TME. Afterward, we filtrated the overlapped genes based on the differentially expressed genes (DEGs) between the metabolic and immune subtypes by lasso regression and Cox regression, and used them to build risk score signature which led to PC patients was categorized into high- and low-risk groups. Furthermore, high-risk patients have a better response for various chemotherapeutic drugs in the Genomics of Drug Sensitivity in Cancer (GDSC) database. Finally, we built a nomogram with the risk group, age, and the number of positive lymph nodes to predict the survival rates of each PC patient with average 1-year, 2-year, and 3-year areas under the curve (AUCs) equal to 0.792, 0.752, and 0.751. In summary, the risk score signature based on the metabolism and immune molecular subtypes can accurately predict the prognosis and guide treatments of PC, meanwhile, the metabolism-immune biomarkers may provide novel target therapy for PC.
Title: Risk factors for non-infectious diarrhea of patients with multiple myeloma after chimeric antigen receptor T-cell immunotherapy: A retrospective observational study
Authors: Ding Shu-Yi , Cheng Yin , Huang Yi-Jie , Gao Xin , Yan Jia-Li , Wang Lin-Qin , Zhao Hou-Li , Wang Rui , Chen Sang-Sang , Teng Tian-Li , Liu Nian , Zhang Ming-Ming , Jin Ai-Yun , Hu Yong-Xian 
Published: February 2023

Abstract
Purpose
To ascertain the risk factors and prevalence of non-infectious diarrhea among participants with multiple myeloma who treated with chimeric antigen receptor T-cell immunotherapy.
Methods
This study enrolled 88 patients with multiple myeloma who received chimeric antigen receptor T-cell immunotherapy at one tertiary general hospital in China. Participants were categorized into diarrhea subgroup and non-diarrhea subgroup according to the occurrence of diarrhea. Demographic data and self-reported measurements and planning were obtained from questionnaires and clinical data from hospital databases.
Results
In total, 50 patients suffered from non-infectious diarrhea, with the prevalence of 56.8%. Multiple logistic regression analysis showed that severe cytokine release syndrome (OR = 5.980), underlying diseases (OR = 4.184), previous treatment lines ≥ 6 (OR = 6.292) were prominent hazardous factors for non-infectious diarrhea (p < 0.05).
Conclusion
The incidence rate of non-infectious diarrhea in patients with multiple myeloma after CAR-T therapy was at a high level. Severe cytokine release syndrome, previous treatment lines ≥ 6 and the underlying diseases were important predictors for non-infectious diarrhea. Medical staff should early evaluate these major factors to reduce the risk of diarrhea (184 words).
One year of experience with combined pharmacokinetic/pharmacogenetic monitoring of anti-TNF alpha agents: a retrospective study
Authors: Clementi Emilio , Cheli Stefania , Savino Diego , De Silvestri Annalisa , Norsa Lorenzo , Sansotta Naire , Penagini Francesca , Dilillo Dario , Panceri Roberto , Cattaneo Dario , Zuin Giovanna 
Published: February 2023

Abstract
Anti-tumor necrosis factor alpha (anti-TNFα) inhibitors are used extensively for the management of moderate to severe inflammatory bowel disease (IBD) in both adult and pediatric patients. Unfortunately, not all patients show optimal response to induction therapy, while others lose their response over time, for reasons yet poorly understood. We report on a pharmacokinetic/pharmacogenetic approach to monitor the therapy with anti-TNFα in a real-world cohort of seventy-nine pediatric patients affected by IBD that was analyzed retrospectively. We evaluated serum concentrations of infliximab, adalimumab and related anti-drug antibodies (ADAs), and single nucleotide polymorphisms (SNPs) in genes involved in immune processes and inflammation on anti-TNFα response. We found a significant association between the SNP in TNFα promoter (-308G > A) and clinical remission without steroids in patients on infliximab therapy. Additionally, a potential connection between HLA-DQA1*05 genetic variant carriers and a higher risk of anti-TNFα immunogenicity emerged.
Common laboratory diets differentially influence zebrafish gut microbiome’s successional development and sensitivity to pathogen exposure
Authors: Sieler Michael , Al-Samarrie Colleen , Kasschau Kristin , Varga Zoltan , Kent Michael , Sharpton Thomas 
Published: February 2023

Abstract
Background: Despite the long-established importance of zebrafish (Danio rerio) as a model organism and their increasing use in microbiome-targeted studies, relatively little is known about how husbandry practices involving diet impact the zebrafish gut microbiome. Given the microbiome’s important role in mediating host physiology and the potential for diet to drive variation in microbiome composition, we sought to clarify how three different dietary formulations that are commonly used in zebrafish facilities impact the gut microbiome. We compared the composition of gut microbiomes in approximately 60 AB line adult (4- and 7-month-old) zebrafish fed each diet throughout their lifespan.
Results: Our analysis finds that diet has a substantial impact on the composition of the gut microbiome in adult fish, and that diet also impacts the developmental variation in the gut microbiome. We further evaluated whether the 7-month-old fish microbiome compositions that result from dietary variation are differentially sensitive to infection by a common laboratory pathogen, Mycobacterium chelonae. Our analysis finds that the gut microbiome’s sensitivity to M. chelonae infection varies as a function of diet, especially for moderate and low abundance taxa.
Conclusions: Overall, our results indicate that diet drives the successional development of the gut microbiome as well as its sensitivity to exogenous exposure. Consequently, investigators should carefully consider the role of diet in their microbiome zebrafish investigations, especially when integrating results across studies that vary by diet.
The Shared Decision-Making Tool for Caregivers of Children with Prenatal Opioid Exposure: A Pilot and Acceptability Study
Authors: Arter Sara , Bush Elsie , Clark Katie , Weber Stephanie 
Published: February 2023

Abstract

The purpose of this pilot study was to report initial findings about developmental concerns expressed by caregivers of children with prenatal opioid exposure using the Shared Decision-Making Tool, and to assess provider acceptability of incorporating the tool into their workflow. Data were collected from 83 caregivers and five providers from a medical clinic and an early intervention service center. Communication was the most frequently cited concern in four consecutive age categories. Inattention/impulsivity was the second most frequently cited concern in three consecutive age categories. Problem behavior was the third most frequently cited concern in three age categories. All providers ‘strongly agreed’ or ‘agreed’ with all statements on the provider feedback survey, except two instances. Data from this pilot study will guide our next research steps, focusing on psychometric testing and usability feedback from caregivers, before expanding trials of the Shared Decision-Making Tool to a wider geographic area. Findings from this pilot study will also inform the development of caregiver resources for managing areas identified as top concerns through the first five years of childhood.