bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Evaluation of Dengue Vector Surveillance, Tainan City, Taiwan, 2011-2013
Authors: Chi Chin-Sheng , Chen WC , Lo YC 
Published: June 2023

Outbreaks of dengue fever (DF) are more common in southern than northern Taiwan, with primary transmission through Aedes aegypti mosquito vectors. A dengue vector surveillance system (DVSS) was established in 2005, with the objectives of characterizing dengue vector distribution and evaluating the effectiveness of DF control measures. We evaluated DVSS in Tainan City, a southern city in Taiwan with DF transmission. During 2011-2013, Ae. aegypti predominance was found in 31% of 36 districts. Breteau, container and household indices decreased following district-level vector control campaigns in 2011 and 2013. Levels of data validity and entry error types were more than 90% and less than 10% respectively. Program completeness was found to be low at 17%, primarily influenced by rural neighborhood findings. Completeness of pupal indices was unsatisfactory (12%), limited by time and manpower in collecting pupae. This evaluation of DVSS showed that the system collected complete and valid data necessary for meeting the surveillance objectives. We recommended that completeness of DVSS be further improved in rural districts, pupal index be removed from routine dengue vector surveys, and on-the-job training of survey personnel be established and maintained.
Etnozoología quichua para la conservación de los mamíferos ungulados en la Amazonía central del Ecuador provincia Pastaza
Authors: Jácome-Negrete Iván , Tanchima Venancio , Santi Patricio , Vargas Cristian 
Published: June 2023

Se realizó un estudio etnozoológico preliminar para investigar el estado de conservación de los mamíferos ungulados, sus usos, la intensidad estacional de su caza y proponer alternativas para su conservación, desde el etnoconocimiento del Pueblo Quichua de Curaray, en la Amazonía central del Ecuador. La riqueza de ungulados locales fue evaluada mediante 195 km. recorridos en transectos lineales. Los usos fueron investigados en talleres. Las preferencias de caza sobre este grupo de fauna fueron documentadas con encuestas aplicadas a 35 cazadores quichuas. Las alternativas de conservación fueron identificadas participativamente en talleres comunitarios. En Curaray coexisten 5 especies de ungulados siendo el tapir y el pecarí de collar los más abundantes. Todos los ungulados registraron usos como alimento, medicina, artesanía, ritual y animal de compañía. En el verano, los ungulados cazados representaron un 27% del número total de mamíferos cazados mensualmente con una contribución en biomasa de un 74% de la biomasa total extraída, siendo las especies más sensibles a la caza el tapir y los pecaríes. Para los cazadores quichua, las poblaciones de todos los ungulados están en declive por el aumento de la caza comercial y la pérdida de conocimientos ancestrales de respeto a la fauna y sus ambientes. Ante ello, las familias proponen crear zonas de cosecha regulada y conservación de la fauna dentro del territorio y aplicar normas para la veda temporal del tapir, cuotas de cosecha para los pecaríes y protección de los saladeros como sitios sagrados.
Sistem Layanan Informasi PT Chacha Networking System
Authors: Nur Nazruddin Mufti , Muhallim Muhlis , Ali Hakam Dani Ahmad 
Published: June 2023

Sepertinya website sudah menjadi sebuah kebutuhan bagi setiap organisasi, instansi, perusahaan komersil, dan lain sebagainya. Kebutuhan tersebut biasanya tidak hanya untuk promosi, namun juga berbagai kegiatan lainnya. PT Chacha Networking System adalah perusahaan yang bergerak di bidang penyedia jasa internet atau Internet Service Provider sehingga sangat membutuhkan sebuah media dalam perluasan pemasaran yang sifatnya mudah di akses bagi pelanggan maupun masyarakat. Untuk itu dalam penulisan tugas akhir ini penulis membuat sebuah sistem layanan informasi terpusat dalalm bentuk website sebagai media utama penyedia layanan informasi bagi perusahaan untuk masyarakat guna mengakses informasi terkait update perusahaan maupun dalam melakukan pendaftaran secara online. Dalam perancangan sistem ini penulis menggunakan metode waterfall, untuk bahasa pemrograman yang di gunakan adalah PHP dengan framework Laravel dan media Visual studio code sebagai editor penulisan program serta data base yang di gunakan adalah MySql. Sistem layanan ini dinilai efektif sebagai media layanan informasi pada perusahaan yang menyediakan fitur pendaftaran online yang dapat di akses guna memudahkan calon pelanggan dalam melakukan registrasi pelanggan baru. Sehinggan manajemen data pelanggan sangat efisien karna telah di digitalisasikan. Penulis berharap dengan adanya layanan ini dapat berbanding lurus dengan peningkatan yang di terima oleh perusahaan dalam setiap aspek
Hubungan intensitas penggunaan Gadget dengan kemampuan bahasa Anak usia 3-6 tahun di Kb/Tk Sri Juwita Hanum Mojosongo Surakarta
Authors: Fadilla Azza Illya Putri Nur , Soesyasmoro R. Asto 
Published: June 2023

Abstrak

Latar Belakang: Dalam berkomunikasi membutuhkan kemampuan bahasa yang baik. Perkembangan bahasa juga dibentuk dari interaksi dengan orang lain. Maka dari itu gadget yang digunakan secara berlebihan dan tidak terkontrol dapat berakibat buruk dalam hal psikologi dan anak tidak dapat dengan lancar bersosialisasi atau berkomunikasi dengan sekitarnya.
Tujuan: Penelitian ini bertujuan untuk mengetahui Hubungan Intensitas Penggunaan Gadget dengan Kemampuan Bahasa Anak Usia 3-6 Tahun di KB/TK Sri Juwita Hanum Mojosongo Surakarta.
Metode: Penelitian ini merupakan penelitian kuantitatif. Desain yang digunakan dalam penelitian ini adalah korelasional dan menggunakan pendekatan cross sectional. Jumlah sampel yang digunakan sebanyak 36 sampel. Teknik sampling yang digunakan adalah teknik purposive sampling. Instrumen penelitian ini menggunakan kuesioner intensitas penggunaan gadget, Reseptive One-Word Picture Vocabulary Test (ROWPVT) untuk menguji kemampuan bahasa reseptif anak, dan Expressive 39 One-Word Picture Vocabulary Test (EOWPVT) untuk menguji kemampuan bahasa ekspresif anak.
Hasil: Berdasarkan uji hipotesis korelatif yang dilakukan menggunakan uji Kendall Tau diperoleh p value 0,102 yang mana artinya hal tersebut menunjukan bahwa nilai p > 0,05 Sehingga dapat disimpulkan hasil yang diperoleh adalah H0 diterima dan Ha ditolak. Yang artinya hal ini menunjukan tidak ada hubungan antara intensitas penggunaan gadget dengan kemampuan bahasa anak. Besarnya korelasi/kuatnya hubungan antara kedua variabel tersebut ditunjukan dengan nilai koefisien korelasi (r) = -0,264 yang berarti dalam kategori sangat lemah.
Kesimpulan: Penelitian ini dapat disimpulkan bahwa tidak terdapat hubungan antara intensitas penggunaan gadget dengan kemampuan bahasa anak usia 3-6 tahun di KB/TK Sri Juwita Hanum Mojosongo Surakarta.
Kata kunci: Gadget, Intensitas Penggunaan Gadget, Kemampuan Bahasa Anak.
Rancang Bangun Sistem Informasi Mesjid Al Huda
Authors: Hermawan Reza , Fitrianto Rahmad Iwan 
Published: June 2023

Mesjid sering disebut Baitullah (rumah Allah) yang digunakan sebagai tempat ibadah. Selain berfungsi sebagai tempat ibadah, mesjid juga berfungsi sebagai wadah pendidikan dan kegiatan-kegiatan sosial lainnya sehingga dapat memberikan manfaat bagi jamaahnya dan bagi masyarakat sekitar. Mesjid Al Huda merupakan kategori masjid Jami’ dibangun pada tahun 1982 yang beralamat di Jl. Rawe IV Lingkungan VI Kel.Tangkahan Medan Labuhan, Kota Medan. Masjid Al Huda terdapat beberapa kegiatan rutin yang dilaksanakan meliputi kegiatan sholat berjamaah, sholat jumat, pengajian remaja, pengajian ibu-ibu, pengajian umum, pengajian tafsir Al-Quran, pengajian Hadist, musyawarah pengurus masjid, pembagian santunan anak yatim, gotong royong remaja dan pengurus masjid serta kegiatan TPA (Taman Pendidikan Al-Quran) dan Keuangan. Permasalahan yang terjadi pada Mesjid AL Huda adalah pada proses pendataan kegiatan dan pemberian informasi keuangan kepada jamaah masih dilakukan secara manual, yaitu dengan memberikan informasi melalui papan pengumuman yang ada di Masjid, dan melalui pengumuman pada saat kegiatan sebelumnya sehingga pada saat pelaksanaan kegiatan dirasakan kurang maksimal. Dengan permasalahan yang dihadapi pengurus masjid di atas dan meningkatnya penggunaan android di masyarakat, maka diperlukan suatu aplikasi yang dapat diakses melalui smartphone android untuk mendata serta menyajikan informasi kegiatan masjid dengan cepat dan mudah. Adapun solusi dari permasalahan yang terjadi pada mesjid Al Huda.
¿La competencia digital docente favorece la inclusión educativa?
Authors: Kerexeta Brazal Itziar , Darretxe Urrutxi Leire 
Published: June 2023

Research has shown that both educational inclusion and digital competence are priorities in education today. However, not all studies link these two issues. Therefore, this article, which is part of a broader research, aims to analyse the meaning of educational inclusion and teachers' digital competences in the case of conectandoescuelas.org in order to identify aspects that facilitate better quality in education. We conducted a qualitative study through 6 focus groups meetings in the Basque Country and Latin America with K-12 teachers. The data were transcribed and analysed using the semantic analysis software NVIVO 1.2 Release. It was found that society is becoming increasingly technological and this has an impact on schools. While it is not easy to define what it means to be digitally competent and educationally inclusive, teachers face barriers in implementing ICT in their daily lives. Although they have facilitating applications in the teaching-learning process, more training is still needed to respond to current challenges.
The conclusions indicate that technology and digital competences for teachers can support educational inclusion, although at present they are still theoretical and idealised constructs that require more contextualised training to respond to the great challenge facing schools today.
La investigación ha demostrado que tanto la inclusión educativa como la competencia digital son prioridades en la educación actual. Sin embargo, no todos los estudios relacionan estas dos cuestiones. Por ello este artículo, que se enmarca dentro de una investigación más amplia, pretende analizar el significado de la inclusión educativa y las competencias digitales docentes en el caso conectandoescuelas.org para identificar aspectos que facilitan una mejor calidad en educación. Optamos por un estudio cualitativo a través de 6 sesiones con grupos focales en Euskadi y Latinoamérica con profesorado de escuelas obligatorias. Los datos se transcribieron y analizaron mediante el software de análisis semántico NVIVO 1.2. Release. Se encontró que la sociedad es cada vez más tecnológica y eso repercute en la escuela. Aunque resulta complejo definir lo que significa ser competente digitalmente y la inclusión educativa, el profesorado se enfrenta a barreras para poder implementar las TIC en su día a día. Si bien cuentan con aplicaciones facilitadoras en el proceso de enseñanza-aprendizaje, todavía se necesita más formación para responder a los retos actuales. Las conclusiones indican que la tecnología y las competencias digitales docentes pueden favorecer la inclusión educativa, aunque en el momento actual aún suponen constructos teóricos e idealizados que demandan más formación contextualizada para responder al gran reto al que se enfrenta la escuela actualmente.
Goals of Care Among Parents of Children Receiving Palliative Care
Authors: Feudtner Chris , Beight Leah J. , Boyden Jackelyn Y. , Hill Douglas L. , Hinds Pamela S. , Johnston Emily E. , Friebert Sarah E. , Bogetz Jori F. , Kang Tammy I. , Hall Matt , Nye Russell T. , Wolfe Joanne ,   PPCRN SHARE Project Group, Arevalo-Soriano Tatiana , Bilodeau Madeline , Catrine Kris , Chapman Jennifer , Crew Karen , Das Porag Jeet , Friebert Sarah , Griffis Heather , Hays Ross , Helton Gabby , Jenkins Rachel , Katkoff Hannah , Kostoff Ali , Maglionico Deborah , Martinez Isaac , Mercer Amanda , Morris Ashley , Nelpati Shimel , Porth Rachel , Sherr Nicole E. , Shipman Kelly , Xiao Rui , Walla Namrata 
Published: June 2023

ImportanceWhile knowing the goals of care (GOCs) for children receiving pediatric palliative care (PPC) are crucial for guiding the care they receive, how parents prioritize these goals and how their priorities may change over time is not known.ObjectiveTo determine parental prioritization of GOCs and patterns of change over time for parents of children receiving palliative care.Design, Setting, and ParticipantsA Pediatric Palliative Care Research Network’s Shared Data and Research cohort study with data collected at 0, 2, 6, 12, 18, and 24 months in hospital, outpatient, or home settings from April 10, 2017, to February 15, 2022, at 7 PPC programs based at children’s hospitals across the US. Participants included parents of patients, birth to 30 years of age, who received PPC services.ExposuresAnalyses were adjusted for demographic characteristics, number of complex chronic conditions, and time enrolled in PPC.Main OutcomesParents’ importance scores, as measured using a discrete choice experiment, of 5 preselected GOCs: seeking quality of life (QOL), health, comfort, disease modification, or life extension. Importance scores for the 5 GOCs summed to 100.ResultsA total of 680 parents of 603 patients reported on GOCs. Median patient age was 4.4 (IQR, 0.8-13.2) years and 320 patients were male (53.1%). At baseline, parents scored QOL as the most important goal (mean score, 31.5 [SD, 8.4]), followed by health (26.3 [SD, 7.5]), comfort (22.4 [SD, 11.7]), disease modification (10.9 [SD, 9.2]), and life extension (8.9 [SD, 9.9]). Importantly, parents varied substantially in their baseline scores for each goal (IQRs more than 9.4), but across patients in different complex chronic conditions categories, the mean scores varied only slightly (means differ 8.7 or less). For each additional study month since PPC initiation, QOL was scored higher by 0.06 (95% CI, 0.04-0.08) and comfort scored higher by 0.3 (95% CI, 0-0.06), while the importance score for life extension decreased by 0.07 (95% CI, 0.04-0.09) and disease modification by 0.02 (95% CI, 0-0.04); health scores did not significantly differ from PPC initiation.Conclusions and RelevanceParents of children receiving PPC placed the highest value on QOL, but with considerable individual-level variation and substantial change over time. These findings emphasize the importance of reassessing GOCs with parents to guide appropriate clinical intervention.
MeCP2 dysfunction prevents proper BMP signaling and neural progenitor expansion in brain organoid
Authors: Hong Hyowon , Yoon Sae‐Bom , Park Jung Eun , Lee Jung In , Kim Hyun Young , Nam Hye Jin , Cho Heeyeong 
Published: June 2023

AbstractObjectivesSporadic mutations in MeCP2 are a hallmark of Rett syndrome (RTT). Many RTT brain organoid models have exhibited pathogenic phenotypes such as decreased spine density and small size of soma with altered electrophysiological signals. However, previous models are mainly focused on the phenotypes observed in the late phase and rarely provide clues for the defect of neural progenitors which generate different types of neurons and glial cells.MethodsWe newly established the RTT brain organoid model derived from MeCP2‐truncated iPS cells which were genetically engineered by CRISPR/Cas9 technology. By immunofluorescence imaging, we studied the development of NPC pool and its fate specification into glutamatergic neurons or astrocytes in RTT organoids. By total RNA sequencing, we investigated which signaling pathways were altered during the early brain development in RTT organoids.ResultsDysfunction of MeCP2 caused the defect of neural rosette formation in the early phase of cortical development. In total transcriptome analysis, BMP pathway‐related genes are highly associated with MeCP2 depletion. Moreover, levels of pSMAD1/5 and BMP target genes are excessively increased, and treatment of BMP inhibitors partially rescues the cell cycle progression of neural progenitors. Subsequently, MeCP2 dysfunction reduced the glutamatergic neurogenesis and induced overproduction of astrocytes. Nevertheless, early inhibition of BMP pathway rescued VGLUT1 expression and suppressed astrocyte maturation.InterpretationOur results demonstrate that MeCP2 is required for the expansion of neural progenitor cells by modulating BMP pathway at early stages of development, and this influence persists during neurogenesis and gliogenesis at later stages of brain organoid development.
Combination Therapy With CD147‐Targeted Nanoparticles Carrying Phenformin Decreases Lung Cancer Growth
Authors: Pereira‐Nunes Andreia , Ferreira Helena , Abreu Sara , Guedes Marta , Neves Nuno M. , Baltazar Fátima , Granja Sara 
Published: June 2023

AbstractLung cancer is one of the most fatal cancers worldwide. Resistance to conventional therapies remains a hindrance to patient treatment. Therefore, the development of more effective anti‐cancer therapeutic strategies is imperative. Solid tumors exhibit a hyperglycolytic phenotype, leading to enhanced lactate production; and, consequently, its extrusion to the tumor microenvironment. Previous data reveals that inhibition of CD147, the chaperone of lactate transporters (MCTs), decreases lactate export in lung cancer cells and sensitizes them to phenformin, leading to a drastic decrease in cell growth. In this study, the development of anti‐CD147 targeted liposomes (LUVs) carrying phenformin is envisioned, and their efficacy is evaluated to eliminate lung cancer cells. Herein, the therapeutic effect of free phenformin and anti‐CD147 antibody, as well as the efficacy of anti‐CD147 LUVs carrying phenformin on A549, H292, and PC‐9 cell growth, metabolism, and invasion, are evaluated. Data reveals that phenformin decreases 2D and 3D‐cancer cell growth and that the anti‐CD147 antibody reduces cell invasion. Importantly, anti‐CD147 LUVs carrying phenformin are internalized by cancer cells and impaired lung cancer cell growth in vitro and in vivo. Overall, these results provide evidence for the effectiveness of anti‐CD147 LUVs carrying phenformin in compromising lung cancer cell aggressiveness.
Integration of Activation by Hypoxia and Inhibition Resistance of Tumor Cells to Apoptosis for Precise and Augmented Photodynamic Therapy
Authors: Shao Yutong , Chen Miaomiao , Chen Wenlong , Wang Zehui , Sui Mengzhang , Tian Mingyu , Wu Yingnan , Song Jitao , Ji Debin , Song Fengling 
Published: June 2023

AbstractPhotodynamic therapy (PDT) uses photosensitizers to convert oxygen (O2) to reactive oxygen species (ROS) under irradiation to induce DNA damage and kill cancer cells. However, the effect of PDT is usually alleviated by apoptosis resistance mechanism of tumor living cells. MTH1 enzyme is known to be such an apoptosis‐resistance enzyme which is over expressed as a scavenger to repair the damaged DNA. In this work, a hypoxia‐activated nanosystem FTPA, which can be degraded to release the encapsulated PDT photosensitizer 4‐DCF‐MPYM and an inhibitor TH588 is proposed. The inhibitor TH588 can inhibit the DNA repair process by reducing the activity of MTH1 enzyme, and achieve the purpose of amplifying the therapeutic effect of PDT. This work demonstrates that a precise and augmented tumor PDT is achieved by integration of hypoxia‐activation and inhibition resistance of tumor cells to apoptosis.
Large Anomalous Nernst Effects at Room Temperature in Fe3Pt Thin Films
Authors: Li Minghang , Pi Hanqi , Zhao Yunchi , Lin Ting , Zhang Qinghua , Hu Xinzhe , Xiong Changmin , Qiu Zhiyong , Wang Lichen , Zhang Ying , Cai Jianwang , Liu Wuming , Sun Jirong , Hu Fengxia , Gu Lin , Weng Hongming , Wu Quansheng , Wang Shouguo , Chen Yunzhong , Shen Baogen 
Published: June 2023

AbstractHeat current in ferromagnets can generate a transverse electric voltage perpendicular to magnetization, known as anomalous Nernst effect (ANE). ANE originates intrinsically from the combination of large Berry curvature and density of states near the Fermi energy. It shows technical advantages over the conventional longitudinal Seebeck effect in converting waste heat to electricity due to its unique transverse geometry. However, materials showing giant ANE remain to be explored. Herein, a large ANE thermopower of Syx ≈ 2 µV K−1 at room temperature in ferromagnetic Fe3Pt epitaxial films is reported, which also show a giant transverse thermoelectric conductivity of αyx ≈ 4 A K−1 m−1 and a remarkable coercive field of 1300 Oe. The theoretical analysis reveals that the strong spin‐orbit interaction in addition to the hybridization between Pt 5d and Fe 3d electrons leads to a series of distinct energy gaps and large Berry curvature in the Brillouin zone, which is the key for the large ANE. These results highlight the important roles of both Berry curvature and spin‐orbit coupling in achieving large ANE at zero magnetic field, providing pathways to explore materials with giant transverse thermoelectric effect without an external magnetic field.
Direct‐Current Electrical Detection of Surface‐Acoustic‐Wave‐Driven Ferromagnetic Resonance
Authors: Chen Chong , Han Lei , Liu Peisen , Zhang Yichi , Liang Shixuan , Zhou Yongjian , Zhu Wenxuan , Fu Sulei , Pan Feng , Song Cheng 
Published: June 2023

AbstractSurface acoustic waves (SAW) provide a promising platform to study spin‐phonon coupling, which can be achieved by SAW‐driven ferromagnetic resonance (FMR) for efficient acoustic manipulation of spin. Although the magneto‐elastic effective field model has achieved great success in describing SAW‐driven FMR, the magnitude of the effective field acting on the magnetization induced by SAW still remains hard to access. Here, by integrating ferromagnetic stripes with SAW devices, direct‐current detection for SAW‐driven FMR based on electrical rectification is reported. By analyzing FMR rectified voltage, the effective fields are straightforwardly characterized and extracted, which exhibits the advantages of better integration compatibility and lower cost than traditional methods such as vector‐network analyzer‐based techniques. A large nonreciprocal rectified voltage is obtained, which is attributed to the coexistence of in‐plane and out‐of‐plane effective fields. The effective fields can be modulated by controlling the longitudinal and shear strains within the films to achieve almost 100% nonreciprocity ratio, demonstrating the potential for electrical switches. Besides its fundamental significance, this finding provides a unique opportunity for a designable spin acousto‐electronic device and its convenient signal readout.