bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of Chinese medicine quality of life assessment scale (CQ-11D) and EQ-5D-5L and SF-6D scales based on Chinese population
Authors: Zhou Jiameng , Xu Longchen , Pan Jie , Wang Muqing , Zhou Pingda , Wang Wei , Lu Siqi , Zhu Wentao 
Published: September 2023

Abstract
Purpose
To measure health-related quality of life in the Chinese population using three universal health utility scales (CQ-11D, EQ-5D-5L, and SF-6D) and to compare the differences in the results obtained by the different scales to provide a reference for future utility on health-related quality of life in the Chinese population.

Methods
According to the Chinese population's distribution area, gender, and age, quota sampling was conducted. Three scales, CQ-11D, EQ-5D-5L, and SF-6D, whose results were self-reported, were collected in succession after collecting respondents' demographic information. The health utility value and floor/ceiling effect were explained. Bland–Altman was used to evaluate the consistency, the intraclass correlation coefficient was used to evaluate the correlation, and the receiver operating characteristic curve was used to evaluate the discriminative validity of the scale.

Results
The mean utility values of the CQ-11D, EQ-5D-5L, and SF-6D scales, respectively, were 0.891, 0.927, and 0.841. The floor effect did not appear in any of the three scales, but the ceiling effect did, and the EQ-5D-5L ceiling effect was the most severe. The limits of the agreement interval for CQ-11D versus EQ-5D-5L in the total sample population were (-0.245,0.172); for CQ-11D versus SF-6D, they were (− 0.256,0.354); and for EQ-5D-5L versus SF-6D, they were (-0.199,0.371). The consistency of the three scales is satisfactory overall. In the total population, the intraclass correlation coefficient between CQ-11D and EQ-5D-5L was 0.709, while EQ-5D-5L and SF-6D were 0.0.565 and that between EQ-5D-5L and SF-6D was 0.472. According to the subject operation curve results, the area under the curve for the total sample population of CQ-11D was 0.746, EQ-5D-5L was 0.669, and SF-6D was 0.734.

Conclusion
The CQ-11D is inferior to the EQ-5D-5L, but superior to the SF-6D. There is a strong correlation between the health utility values of the total population as measured by the three scales and those of the healthy population. The CQ-11D scale is the most sensitive to differences between populations and diseases.
On restricted approximation measures of Jacobi’s triple product
Authors: Leinonen Leena , Leinonen Marko 
Published: September 2023

AbstractWe obtain rational approximations for Jacobi’s triple product $$\begin{aligned} \Pi _q(t):= \prod _{m=1}^\infty (1-q^{2m})(1+q^{2m-1}t)(1+q^{2m-1}t^{-1}), \end{aligned}$$

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Elderly vs. Working-Age Generation: Homeownership and Housing Asset Inequality in a Cross-Country Perspective
Authors: Marcinkiewicz Edyta 
Published: September 2023

AbstractThis study contributes to the discussion about wealth inequality, albeit from a more detailed housing perspective. It explores tenure inequality, as well as housing assets inequality. The latter includes a different approach than the one that prevails in the previous literature on wealth inequalities, which most often considers total net worth or net housing wealth. This study focuses on gross housing asset distribution, irrespective of mortgage debt, which corresponds with the potential of housing equity accumulation as a source of income in old age. It emphasises the intergenerational context, but simultaneously involves cross-country comparisons that allow for relative assessment of the intergenerational differences. Drawing from the Luxembourg Wealth Study (LWS) dataset the paper presents the results for fourteen developed countries. They suggest that the current working-age generation is to a lesser extent involved into homeownership, as compared to the older generation, which results in a smaller housing equity per household, but simultaneously it experiences greater housing inequality. Furthermore, as shown in a cross-country perspective, homeownership rates and housing asset inequality are negatively correlated. Consequently, higher housing asset inequality by lower homeownership rates are the factors that undermine the usefulness of the asset-based welfare concepts in a policy application. Such findings imply that in the macro perspective the potential of housing as a source of additional income in cash and in kind tends to shrink.
Increased bat activity at urban water sources: implications for cross-species transmission of bat rabies to mesocarnivores
Authors: Hastings Lias A. , Chambers Carol L. , Bergman David L. , Theimer Tad C. 
Published: September 2023

AbstractWe examined the potential for urban water sources, specifically golf course ponds, to act as centers for rabies transmission from bats to mesocarnivores in the arid southwestern United States where surface water is often limited. Because residential housing can act as den and roost sites for both mesocarnivores and bats, we also examined the effect of housing density around water sources on activity. Using ultrasonic acoustic recorders to assess bat activity and camera traps to estimate mesocarnivore activity, we compared 14 pairs of wet and dry locations over two years by surveying twice during the summer, once prior to summer monsoons and once during the monsoon season, when surface waters were more available. Number of calls for all bat species combined were greater at wet sites compared to dry sites and calls of two bat species often associated with rabies, big brown bat (Eptesicus fuscus) and silver-haired bat (Lasionycteris noctivagans), were recorded more at wet sites than dry sites in the monsoon season. In both years, raccoons (Procyon lotor) were photographed more often at wet sites while striped skunks (Mephitis mephitis) and gray foxes (Urocyon cinereoargenteus) were less likely to be detected at wet sites. Bat, fox and raccoon activity was not associated with housing density while striped skunks showed a positive correlation. Finally, we examined potential for contact between mesocarnivores and big brown bats, a species implicated in cross-species rabies transmission in our area, by combining call activity of this bat species and photo detections of mesocarnivores during individual hours of the night into a Potential Contact Index (PCI) and found no significant effect of season (pre-monsoon vs. monsoon), species, or treatment (dry versus wet) but did find a significant species by treatment interaction, with raccoon PCI 3–30 times higher at wet sites and no effect on the other two mesocarnivores’ PCI. Overall, we found higher activity of bats at urban waters could increase potential for cross-species transmission of rabies from bats to raccoons but not for gray foxes and striped skunks.
Domain-Specific Optimisations for Image Processing on FPGAs
Authors: Ali Teymoor , Bhowmik Deepayan , Nicol Robert 
Published: September 2023

AbstractImage processing algorithms on FPGAs have increasingly become more pervasive in real-time vision applications. Such algorithms are computationally complex and memory intensive, which can be severely limited by available hardware resources. Optimisations are therefore necessary to achieve better performance and efficiency. We hypothesise that, unlike generic computing optimisations, domain-specific image processing optimisations can improve performance significantly. In this paper, we propose three domain-specific optimisation strategies that can be applied to many image processing algorithms. The optimisations are tested on popular image-processing algorithms and convolution neural networks on CPU/GPU/FPGA and the impact on performance, accuracy and power are measured. Experimental results show major improvements over the baseline non-optimised versions for both convolution neural networks (MobileNetV2 & ResNet50), Scale-Invariant Feature Transform (SIFT) and filter algorithms. Additionally, the optimised FPGA version of SIFT significantly outperformed an optimised GPU implementation when energy consumption statistics are taken into account.
Towards an understanding of the enzymatic degradation of complex plant mannan structures
Authors: Mafa Mpho Stephen , Malgas Samkelo 
Published: September 2023

AbstractPlant cell walls are composed of a heterogeneous mixture of polysaccharides that require several different enzymes to degrade. These enzymes are important for a variety of biotechnological processes, from biofuel production to food processing. Several classical mannanolytic enzyme functions of glycoside hydrolases (GH), such as β-mannanase, β-mannosidase and α-galactosidase activities, are helpful for efficient mannan hydrolysis. In this light, we bring three enzymes into the model of mannan degradation that have received little or no attention. By linking their three-dimensional structures and substrate specificities, we have predicted the interactions and cooperativity of these novel enzymes with classical mannanolytic enzymes for efficient mannan hydrolysis. The novel exo-β-1,4-mannobiohydrolases are indispensable for the production of mannobiose from the terminal ends of mannans, this product being the preferred product for short-chain mannooligosaccharides (MOS)-specific β-mannosidases. Second, the side-chain cleaving enzymes, acetyl mannan esterases (AcME), remove acetyl decorations on mannan that would have hindered backbone cleaving enzymes, while the backbone cleaving enzymes liberate MOS, which are preferred substrates of the debranching and sidechain cleaving enzymes. The nonhydrolytic expansins and swollenins disrupt the crystalline regions of the biomass, improving their accessibility for AcME and GH activities. Finally, lytic polysaccharide monooxygenases have also been implicated in promoting the degradation of lignocellulosic biomass or mannan degradation by classical mannanolytic enzymes, possibly by disrupting adsorbed mannan residues. Modelling effective enzymatic mannan degradation has implications for improving the saccharification of biomass for the synthesis of value-added and upcycling of lignocellulosic wastes.
Self-reported physical activity level, emotions, feelings and self-perception of older active women: is the water-based exercise a better enhancer of psychophysical condition?
Authors: Del Bianco Marco , Lovecchio Nicola , Pirazzi Agnese , Gatti Alessandro , Pellino Vittoria Carnevale , Cucco Laura , Locatelli Elisabetta , Bombardieri Federico , Bombardieri Laura , Vandoni Matteo 
Published: September 2023

Abstract
Background
Aquatic exercise programs can enhance health and improve functional fitness in older people, while there is limited evidence about the efficacy of aquatic-exercise programs on improving well-being and quality of life.

Aim
The purpose of this study was to determine the effects of a supervised water fitness program on subjective well-being in older women.

Methods
The study group included 166 active older women (> 65 years), divided into water-based (WFG) and land-based (CG) training groups. They filled out 3 questionnaires to assess their amount of physical activity (IPAQ), subjective well-being (PANAS) and mental and physical health status (SF-12).

Results
Results showed that subjective well-being, physical activity level, perceived mental and physical status had higher values in the WFG compared to CG.

Conclusions
We found that older women practicing water fitness tend to have a better subjective physical and mental well-being than those who exercise in a land-based context.
FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer’s disease
Authors: Hamilton Haylee L. , Kinscherf Noah A. , Balmer Garrett , Bresque Mariana , Salamat Shahriar M. , Vargas Marcelo R. , Pehar Mariana 
Published: September 2023

AbstractAlzheimer’s disease (AD), the most common cause of dementia in the elderly, is characterized by the accumulation of intracellular neurofibrillary tangles, extracellular amyloid plaques, and neuroinflammation. In partnership with microglial cells, astrocytes are key players in the regulation of neuroinflammation. Fatty acid binding protein 7 (FABP7) belongs to a family of conserved proteins that regulate lipid metabolism, energy homeostasis, and inflammation. FABP7 expression is largely restricted to astrocytes and radial glia-like cells in the adult central nervous system. We observed that treatment of primary hippocampal astrocyte cultures with amyloid β fragment 25–35 (Aβ25–35) induces FABP7 upregulation. In addition, FABP7 expression is upregulated in the brain of APP/PS1 mice, a widely used AD mouse model. Co-immunostaining with specific astrocyte markers revealed increased FABP7 expression in astrocytes. Moreover, astrocytes surrounding amyloid plaques displayed increased FABP7 staining when compared to non-plaque-associated astrocytes. A similar result was obtained in the brain of AD patients. Whole transcriptome RNA sequencing analysis of human astrocytes differentiated from induced pluripotent stem cells (i-astrocytes) overexpressing FABP7 identified 500 transcripts with at least a 2-fold change in expression. Gene Ontology enrichment analysis identified (i) positive regulation of cytokine production and (ii) inflammatory response as the top two statistically significant overrepresented biological processes. We confirmed that wild-type FABP7 overexpression induces an NF-κB-driven inflammatory response in human i-astrocytes. On the other hand, the expression of a ligand-binding impaired mutant FABP7 did not induce NF-κB activation. Together, our results suggest that the upregulation of FABP7 in astrocytes could contribute to the neuroinflammation observed in AD.
A physics-inspired machine learning approach for water-tightness estimation of defective cut-off walls with random construction errors
Authors: Tao Rui , Pan Yutao , Liu Zhongqiang , Liu Yong , Ritter Stefan 
Published: September 2023

AbstractUnderground cut-off walls are widely used in various geotechnical applications to hinder groundwater flow, contaminant transportation and possibly heat conduction. Cut-off walls were usually found defective due to construction errors during the installation phase, leading to significant leakages in subsequent operation phase. Existing physics-based leakage evaluation approaches, such as the finite element analysis and three-dimensional discretized algorithm, are computationally expensive and may not satisfy the need for instant on-site leakage risk assessment. In this regard, a more efficient mapping between construction errors and performance of cut-off walls is highly demanded. A natural option for such mapping is the artificial intelligence approach. Several novel physics-inspired neural network models are proposed based on the well-designed physical layers with varying complexity, to strike a balance between benefits of machine learning and physical approaches. The result shows that introducing physical layers with clearer physical meaning helps mitigating overfitting problems, improving prediction accuracy, result interpretability and model capacity, at the price of increasing the calculation efficiency during training. An optimized degree of physical meaning clarity can be achieved to strike a balance between fitting effect and training computation cost.
Early kinetics of C-reactive protein as prognosticator for survival in a real-world cohort of patients with metastatic renal cell cancer under first-line therapy with immune checkpoint inhibitors
Authors: Schüttke Vayda , Kusiek Cathrin , Fuessel Susanne , Thomas Christian , Buerk Bjoern Thorben , Erdmann Kati 
Published: September 2023

Abstract
Purpose
This study investigated the prognostic potential of baseline C-reactive protein (CRP) levels and early CRP kinetics in a real-world cohort of patients with metastatic renal cell carcinoma (mRCC) under first-line (1L) therapy with immune checkpoint inhibitors (CPI).

Methods/patients
Analyses were performed retrospectively in a cohort of 61 mRCC patients under CPI-based 1L therapy. Patients were stratified based on baseline CRP (< 10 vs ≥ 10 mg/l) and CRP change within the initial three months of CPI therapy (normal: baseline < 10 mg/l, normalized: baseline ≥ 10 mg/l and nadir < 10 mg/l, non-normalized: baseline and nadir ≥ 10 mg/l). Finally, the association of baseline CRP and CRP change with progression-free (PFS) and overall survival (OS) was evaluated.

Results
Baseline CRP was not significantly associated with both PFS (p = 0.666) and OS (p = 0.143). Following stratification according to early CRP kinetics, 23, 25 and 13 patients exhibited normal, normalized and non-normalized CRP levels, respectively. Patients with normal and normalized CRP had a markedly prolonged PFS (p = 0.091) and OS (p = 0.008) compared to patients with non-normalized CRP. Consequently, significantly better PFS (p = 0.031) and OS (p = 0.002) were observed for the combined normal-normalized group. In multivariate analysis including ECOG and IMDC risk, normalized CRP kinetics alone or in combination with the normal group was identified as significant independent risk factor for OS, whereas a statistical trend was observed for PFS.

Conclusions
The present study emphasizes the prognostic potential of early CRP kinetics in CPI-treated mRCC. As a standard laboratory parameter, CRP can be easily implemented into clinical routine to facilitate therapy monitoring.
Anaerobic Digestion of Hemp and Flax Straw and Shives and Rapeseed Straw by the Ruminal Microbiota
Authors: Figueiredo Aline Fernandes , Brede Melanie , Heller Jannika , Redzepovic Larissa , Illi Lukas , Weichgrebe Dirk 
Published: September 2023

AbstractTo mitigate greenhouse gas emissions and improve energy supply security, there is an increasing effort toward the use of non-fossil energy sources. Crop residues have a great potential to be exploited as biomass for biogas production. However, due to their lignocellulosic structures they are difficult to degrade and do not reach competitive performance. A feasible option to mine these substrates is present in the forestomach of ruminants. Therefore, the aim of the present study was to use rumen microorganisms to improve anaerobic digestion (AD) of crop residues. For this purpose, hemp straw, mechanically pre-treated hemp fibers and shives, flax straw, flax shives, and aged and fresh rapeseed straw were evaluated using the rumen simulation technique. The AD of the substrates was divided into three batches. In two batches, hay was added as a control substrate. In summary, none of the analyzed substrates had an equivalent performance as the control hay, but pre-treated hemp fibers and shives had better AD parameters compared to all other alternative substrates, with the lowest pH (mean: 6.81), highest short chain fatty acid (20.0 mmol/day) and H2 production (25.6 mM) and highest degradability (25.2%). Flax straw had the second-best performance (6.81, 17.4 mmol/day, 20.6 mM and 22.2%, respectively), followed by fresh rapeseed straw, hemp straw, aged rapeseed straw and flax shives. Therefore, hemp fibers and shives demonstrated to be the most suitable substrates for AD. However, since pre-treatment can represent significant additional costs for biogas production, flax straw also demonstrated to be a good alternative.
An Algebraic Geometric Foundation for a Classification of Second-Order Superintegrable Systems in Arbitrary Dimension
Authors: Kress Jonathan , Schöbel Konrad , Vollmer Andreas 
Published: September 2023

AbstractSecond-order (maximally) superintegrable systems in dimensions two and three are essentially classified. With increasing dimension, however, the non-linear partial differential equations employed in current methods become unmanageable. Here we propose a new, algebraic-geometric approach to the classification problem—based on a proof that the classification space for irreducible non-degenerate second-order superintegrable systems is naturally endowed with the structure of a quasi-projective variety with a linear isometry action. On constant curvature manifolds our approach leads to a single, simple and explicit algebraic equation defining the variety classifying those superintegrable Hamiltonians that satisfy all relevant integrability conditions generically. In particular, this includes all non-degenerate superintegrable systems known to date and shows that our approach is manageable in arbitrary dimension. Our work establishes the foundations for a complete classification of second-order superintegrable systems in arbitrary dimension, derived from the geometry of the classification space, with many potential applications to related structures such as quadratic symmetry algebras and special functions.
Carbonate Chemistry and the Potential for Acidification in Georgia Coastal Marshes and the South Atlantic Bight, USA
Authors: Reimer Janet J. , Medeiros Patricia M. , Hussain Najid , Gonski Stephen F. , Xu Yuan-Yaun , Huang Ting-Hsuan , Cai Wei-Jun 
Published: September 2023

AbstractIn coastal regions and marginal bodies of water, the increase in partial pressure of carbon dioxide (pCO2) in many instances is greater than that of the open ocean due to terrestrial (river, estuarine, and wetland) influences, decreasing buffering capacity and/or increasing water temperatures. Coastal oceans receive freshwater from rivers and groundwater as well as terrestrial-derived organic matter, both of which have a direct influence on coastal carbonate chemistry. The objective of this research is to determine if coastal marshes in Georgia, USA, may be “hot-spots” for acidification due to enhanced inorganic carbon sources and if there is terrestrial influence on offshore acidification in the South Atlantic Bight (SAB). The results of this study show that dissolved inorganic carbon (DIC) and total alkalinity (TA) are elevated in the marshes compared to predictions from conservative mixing of the freshwater and oceanic end-members, with accompanying pH around 7.2 to 7.6 within the marshes and aragonite saturation states (ΩAr) <1. In the marshes, there is a strong relationship between the terrestrial/estuarine-derived organic and inorganic carbon and acidification. Comparisons of pH, TA, and DIC to terrestrial organic material markers, however, show that there is little influence of terrestrial-derived organic matter on shelf acidification during this period in 2014. In addition, ΩAr increases rapidly offshore, especially in drier months (July). River stream flow during 2014 was anomalously low compared to climatological means; therefore, offshore influences from terrestrial carbon could also be decreased. The SAB shelf may not be strongly influenced by terrestrial inputs to acidification during drier than normal periods; conversely, shelf waters that are well-buffered against acidification may not play a significant role in mitigating acidification within the Georgia marshes.