bluuebunny/crossref_metadata_2025_split huggingface dataset:
Çocuklarda Flor Uygulamaları Hakkında Bilgi Veren İnternet Sitelerinin İçeriklerinin ve Güvenilirliklerinin Değerlendirilmesi
Authors: AKSOY Merve , BAL Cenkhan 
Published: August 2023

Amaç: Yürütülen çalışmanın amacı internet sitelerindeki flor konulu paylaşımların içerik analizini yapmak ve güvenilirliklerini değerlendirmektir.
Gereç ve Yöntem: Google Chrome tarayıcına 2 anahtar kelime (flor vernik zararlı mı?, çocuklarda flor uygulamaları) girilmiş ve her iki terim için ilk 50 sitenin linki kaydedilmiştir. Türkçe bilgi içermeyen siteler, dublikasyon olanlar, yalnızca video kaydı veya linki olan siteler, soru-cevap forumları, bilimsel yayın ve ders notu linkleri, reklam ve pazarlama amaçlı siteler çalışma dışı bırakılmıştır ve kalan 73 site Discern güvenilirlik analizi ile içerik analizini içeren bir incelemeye tabi tutulmuştur. Elde edilen veriler SPSS 25 programı ile analiz edilmiş, p
Sepsis Prediction in Hospitalized Children: Model Development and Validation
Authors: Stephen Rebecca J. , Carroll Michael S. , Hoge Jeremy , Maciorowski Kimberly , Jones Roderick C. , Lucey Kate , O’Connell Megan , Schwab Carly , Rojas Jillian , Sanchez-Pinto L. Nelson 
Published: August 2023

BACKGROUND AND OBJECTIVES
Early recognition and treatment of pediatric sepsis remain mainstay approaches to improve outcomes. Although most children with sepsis are diagnosed in the emergency department, some are admitted with unrecognized sepsis or develop sepsis while hospitalized. Our objective was to develop and validate a prediction model of pediatric sepsis to improve recognition in the inpatient setting.

METHODS
Patients with sepsis were identified using intention-to-treat criteria. Encounters from 2012 to 2018 were used as a derivation to train a prediction model using variables from an existing model. A 2-tier threshold was determined using a precision-recall curve: an “Alert” tier with high positive predictive value to prompt bedside evaluation and an “Aware” tier with high sensitivity to increase situational awareness. The model was prospectively validated in the electronic health record in silent mode during 2019.

RESULTS
A total of 55 980 encounters and 793 (1.4%) episodes of sepsis were used for derivation and prospective validation. The final model consisted of 13 variables with an area under the curve of 0.96 (95% confidence interval 0.95–0.97) in the validation set. The Aware tier had 100% sensitivity and the Alert tier had a positive predictive value of 14% (number needed to alert of 7) in the validation set.

CONCLUSIONS
We derived and prospectively validated a 2-tiered prediction model of inpatient pediatric sepsis designed to have a high sensitivity Aware threshold to enable situational awareness and a low number needed to Alert threshold to minimize false alerts. Our model was embedded in our electronic health record and implemented as clinical decision support, which is presented in a companion article.
Exploring the relationship between mental health, drug use, personality, and attitudes towards psilocybin-assisted therapy
Authors: Ross Benjamin M. , Neill James T. 
Published: August 2023

AbstractBackgroundPsilocybin, the psychoactive compound in magic mushrooms, is increasingly discussed in terms of its psychotherapeutic potential; however, little is known about community attitudes towards psilocybin assisted therapy (PAT).AimsTo address the question: What are the public's attitudes towards psilocybin and psilocybin-assisted therapy? And what factors explain these attitudes?MethodsThis study investigated the attitudes of 118 young adults in the Australian Capital Territory through an online survey.ResultsParticipants who were more open to experience and who had used recreational drugs were more likely to have positive attitudes towards all aspects of PAT. Additionally, psychedelic drug use and agreeableness was positively associated with attitudes towards psilocybin safety, legality, and research; and psilocybin use was positively associated with attitudes towards psilocybin knowledge and acceptability.ConclusionsThis convenience sample of young adults was generally positively disposed towards PAT. People who were more open to experience and who had used recreational or psychedelic drugs had more favourable attitudes towards PAT.
Ganoderma lucidum extract reverses hepatocellular carcinoma multidrug resistance via inhibiting the function of P-glycoprotein in vitro and in vivo
Authors: Li Jing , Cao Lin , Yuan Cheng , Jiang Zhaojian , Cai Hongfei , Xu Wendong , Han Yaming , Chen Liang , Zhang Qin , Jiang Renwang , Liu Juyan 
Published: August 2023

Cancer is a leading cause of death globally. Chemotherapy still plays an indispensable role in the clinical treatment of cancer. However, the emergence of multidrug resistance (MDR) has greatly obstructed the further application of chemotherapy agents. Ganoderma lucidum (G. lucidum) is a traditional Chinese medicine as well as an edible mushroom. In this study, we first explored the effect of six extract samples derived from G. lucidum on the cell viability of adriamycin-resistant human hepatocellular carcinoma multidrug-resistant cell subline (HepG-2/ADM). All these samples showed no obvious toxicity to cells; however, only G. lucidum ethanol extract could reverse resistance to doxorubicin and paclitaxel. Then the P-glycoprotein (P-gp) function in hepatocellular carcinoma G2 (HepG-2) and HepG-2/ADM cells was determined after incubated with these samples, and we found that G. lucidum ethanol extract could inhibit P-gp function in vitro. Furthermore, G. lucidum ethanol extract could reverse resistance to paclitaxel in HepG-2/ADM tumor-bearing mice in vivo, while the protein expression level of P-gp was unchanged. Taken together, these results indicated the potential role of G. lucidum ethanol extract in reversing MDR in the clinical treatment of hepatocellular carcinoma.
Modal Verbs in Sustainability Reports by the University of Cambridge and the University of Oxford
Authors: Kapranov Oleksandr 
Published: August 2023

This article presents and discusses a study on modal verbs in sustainability reports that are communicated online by the University of Cambridge (UC) and the University of Oxford (UO) in the United Kingdom. The study is based upon a contention proposed by Fløttum (2010), who posits that modal verbs are used in sustainability discourse as micro-linguistic means that are involved in a range of pragma-communicative strategies. Following Fløttum (2010), the present study seeks i) to establish the frequency of the occurrence of the so-called “central” modal verbs, i.e. can/could, may/might, must, shall/should, and will/would and ii) to identify their involvement in the programa-communicative strategies in the sustainability reports by UC and UO. The sustainability reports by UC and UO were analysed in the computer program AntConc version 4.0.11 (Anthony, 2022) in order to compute the frequency of the central modal verbs. Thereafter, they were analysed qualitatively to establish their relationship with a range of pragma-communicative strategies that were employed in the sustainability reports by UC and UO, respectively. The quantitative computer-assisted analysis indicated that can and will were the most frequent modal verbs in the UC’s and UO’s sustainability reports. However, the qualitative investigation demonstrated that can and will were associated with different pragma-communicative strategies in the reports. The findings were further discussed in the article.
Влияние родственного ухода на занятость и материальное положение ухаживающих лиц
Authors: Гришина Елена , Цацура Елена 
Published: August 2023

Проблемы старения населения и возрастания нагрузки на лиц, ухаживающих за родственниками, актуальны как в зарубежных странах, так и в России. На основе данных проведенного в 2020 г. обследования «Человек, семья и общество» нами представлен анализ влияния ухода за родственниками на возможности занятости и материальное положение домохозяйств, в которых есть ухаживающие лица. Среди лиц в возрасте от 18 до 72 лет более 20 % имеют родственников, нуждающихся в уходе, и примерно половина имеющих таких родственников ухаживает за ними лично. Среди ухаживающих более 10 % ощутили, что осуществляемый ими уход негативно сказался на их занятости и привел либо к вынужденному увольнению, либо к сокращению часов работы. Следствием становятся ухудшение материального положения в домохозяйствах, высокие риски малообеспеченности, бедности и крайней бедности, низкие среднедушевые доходы и уменьшение сбережений. Регрессионный анализ показал, что вероятность ухаживающих лиц уволиться с работы или сократить часы работы в связи с уходом сокращается, если другие родственники также помогают в уходе, и возрастает, если требуется интенсивный уход, а также если пожилой родственник с трудом может передвигаться по дому, не имеет возможности самостоятельно купить продукты и приготовить себе еду, его с трудом можно оставить без присмотра в течение дня. Помимо этого, вероятность негативного влияния на занятость выше у более возрастных респондентов и у лиц, проживающих в столицах регионов. Увольнение или сокращение часов работы в связи с уходом снижает среднедушевые доходы в среднем на четверть. Участие социального работника или сиделки в уходе увеличивает среднедушевые доходы респондента в среднем на 9 %.
Стратегии солидарного города в российских малых городах (на примере Алтайского края)
Authors: Попов Евгений 
Published: August 2023

В статье акцент сделан на применении концепта «солидарный город» в отношении малых городов России на примере Алтайского края. Через анализ массового опроса жителей малых городов (N=1220) и интервью с активистами (N=28) показан большой пласт работы местного сообщества на благо города. Необходимость использования указанного концепта продиктована тем, что вопреки имеющимся в современной науке позициям, характеризующим малый город как отчужденное и дезинтег­рированное пространство, в статье представлены результаты иного плана. В частности, показано, что тип солидарного города отражает тесное взаимодействие жителей в решении актуальных проблем развития городской среды. При этом реализуются системные стратегии солидарного города, свидетельствующие не просто об интеграции жителей малых городов, но и активных действиях с вовлеченностью в них разных поколений, трудовых династий, людей всех возрастов и социального положения. Высказывается мысль о том, что именно солидарный город позволяет жителям преодолевать отчуждение и сообща действовать на благо города, притом, что малый город сталкивается с рядом серьезных социально-­экономических и социально-­политических проблем. Выявлены конкретные стратегии солидарного города, которые реализуются активистами, вовлекающими горожан в эти процессы. К числу таких стратегий отнесены: общее дело, взаимная помощь и поддержка, а также взаимодействие жителей малых городов с властью и общественными объединениями. Таким образом, в статье разработана трактовка концепта «солидарный город» применительно к развитию местного социума в российских малых городах, продемонстрированы возможности его реализации в конкретных действиях объединившихся горожан. В конечном итоге солидарный город предстает как наиболее продуктивный тип общественных отношений в условиях определенной городско среды.
CLINICAL EVALUATION OF THE STATE OF RESTORATIONS IN THE AREA OF WEDGE DEFECTS AFTER USING THE WATERLASE IPLUS CHROME-ERBUM LASER AND THE TRADITIONAL PREPARATION METHOD
Authors: Kriheli Natella , Bolashova Svetlana 
Published: August 2023

Subject. Our study evaluated the effectiveness of two methods for the preparation of wedge-shaped defects of the teeth before performing aesthetic restorations: the traditional method of preparation and using Er,Cr:YSGG laser in three different modes. Evaluation of the effectiveness of these methods was carried out the next day after treatment, as well as after 6 and 12 months.
Objectives. To evaluate the clinical condition of restorations using the Er,Cr:YSGG laser and the traditional preparation method.
Methodology. In study i 80 patients were divided into 2 equal groups. The 1st group included patients with wedge-shaped teeth defects, who were prepared by the traditional method, the 2nd group included patients with wedge-shaped teeth defects, who were prepared with the Waterlase Iplus erbium laser (Biolase, USA). The second group was divided into 3 subgroups (13–14 people each), depending on the preparation mode used. All wedge-shaped defects were restored using Filtek Ultimate Flowable and Filtek Ultimate (3M ESPE, USA) composite material with preconditioning with 37% phosphoric acid and application of Adper Single Bond 2 adhesive (3M ESPE, USA).
The condition of the restorations was assessed according to G. Ryge's clinically modified criteria on the next day after treatment, after 6 and 12 months.
Results. Immediately after treatment and after 6 months, the condition of the restored teeth in both groups of traditional and laser preparations was not changed. The first changes in the state of the restorations appeared after 12 months. None of the restorations fell out during the entire treatment period.
Conclusion. Restorations after the treatment of wedge-shaped defects with the Er,Cr:YSGG laser in accordance with G. Ryge's clinical modified criteria for 12 months do not change in 90% of cases and have ALPHA scores for all criteria; with the traditional method of preparation – in 87.5% of cases.
ASSESSMENT OF THE DENTAL STATUS AND INDICATORS OF HOMEOSTASIS OF THE ORAL CAVITY IN FASTING PERSONS
Authors: Mirsaeva Faniya , Gileva Ol'ga , Akmalova Guzel' , Fayzullina Guzel 
Published: August 2023

Subject of study. Dental status, indicators of oral homeostasis in persons, diet and oral hygiene in persons observing the fast of Ramadan.
Purpose of the study. To study the dental status, indicators of homeostasis of the oral cavity and the nature of nutrition in persons observing the fast of Ramadan.
Methodology. The study involved 37 male volunteers, aged 25 to 35 years, belonging to the second health group, who did not undergo SARS-CoV-2, with an orthognathic bite, a satisfactory level of hygiene, a PMA equal to zero, and a KPU index below 1.5. In previous years, the studied persons strictly observed the fast of Ramadan and this year, too, were firmly determined to observe it. Before the start, on the 15th day and after the end of the fast, the study studied the hygienic state of the oral cavity, the state of the teeth, the state of periodontal tissues, the functional activity of the salivary glands, the viscosity and pH of saliva, the level of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and the activity of antioxidant enzymes – superoxide dismutase (SOD), oral fluid catalase. After completing the fast, they filled out questionnaires that included questions about oral care and diet during fasting.
Results. In persons observing the fast of Ramadan, the reaction of saliva is shifted to the acid side, the functional activity of saliva decreases, and the viscosity of saliva increases. This leads to a deterioration in the hygienic state of the oral cavity, the formation of soft and hard deposits on the teeth and the development of gum disease. There is also an imbalance in the lipid peroxidation-antioxidants system, an increase in the concentration of pro-inflammatory cytokines IL-1β, IL-6, TNF-α, both on the 15th day of fasting and after its completion.
Conclusions. The results of the study allow dentists and nutritionists to purposefully develop recommendations on diet and prevention of dental diseases for people who observe the fast of Ramadan.
MODERN APPLICATIONS AND CAPABILITIES OF ARTIFICIAL INTELLIGENCE FOR 3D VISUALIZATION IN DENTAL RESEARCH AND PRACTICE
Authors: Koshelev konstantin , Bazhanov Dmitriy , Belousov Nikolay , Bulanov Vitaliy , Gerasimov Artem 
Published: August 2023

The aim of study. Study the available specialized literature on the use of CBCT in maxillofacial imaging and the combination of this research method with artificial intelligence to improve the diagnosis and treatment of complex dental diseases.
Methodology. The data of special literature were studied using scientific search library databases: Pub Med, Elibrary, Cochrane, Google Scholar.
Results. The use of cone-beam computed tomography (CBCT) in the examination of patients in need of prosthetics allows to obtain a large amount of diagnostic information about the condition of hard tissues of teeth, bone tissue of jaws, temporomandibular joint and nearby anatomical structures in comparison with other radiological methods of additional examination of patients. The possibilities of this type of research were evaluated together with a representative of the "Diagnocat" artificial intelligence system and an analysis of its advantages was carried out. It also describes a comprehensive protocol for planning orthopedic treatment of patients based on digital (virtual) modeling and its advantages for a practicing orthopedic dentist.
Conclusions. The CBCT method is widely used in modern dental practice due to its accuracy, accessibility and high objectivity. Artificial intelligence technologies introduced into the planning process of complex dental treatment are gradually becoming a tool for the practitioner. Automatic recognition of teeth and diagnostics of facial deformities using artificial intelligence systems based on CBCT are very likely to become an area of increased interest in the future. The review is aimed at giving practicing dentists and interested colleagues in the field of healthcare a comprehensive understanding of the current trend in the development of artificial intelligence in the field of 3D visualization in dental medicine.
CLINICAL EVALUATION OF CHRONIC SIMPLE MARGINAL GINGIVITIS TREATMENT EFFICACY WITH THE USE OF SPRAY AGAINST GUM BLEEDING «DENTABALANCE®» SYNBIOTIC COMPLEX INCLUDING LYSATE FROM STREPTOCOCCUS THERMOPHILUS AND PREBIOTICS (MULTICENTER CLINICAL TRIAL)
Authors: Gileva Ol'ga , Sadovski Vladimir , Ermolaeva Lyudmila , Libik Tatiana , Nikolaeva Margarita , Mikhailova Ekaterina , Sycheva Maria 
Published: August 2023

Subject. The subject of the study is the anti-inflammatory and anti-plaque effect of spray against gum bleeding «DentaBalance®» synbiotic complex in the treatment of chronic simple marginal gingivitis.
Objectives. The aim of the study is to conduct a clinical evaluation of spray against gum bleeding «DentaBalance®» synbiotic complex in the complex treatment and hygienic oral care in patients with chronic simple marginal gingivitis (CSMG).
Methodology. A pilot open prospective non-randomized multicenter study was conducted to evaluate the anti-inflammatory and anti-plaque effects of spray against gum bleeding «DentaBalance®» synbiotic complex in the treatment of CSMG. The sample consisted of 99 patients aged 20–33 years with CSMG in localized or generalized form, who used spray against gum bleeding «DentaBalance®» synbiotic complex including lysate from Streptococcus Thermophilus and prebiotics 2 times a day for 4 weeks on their own in-home therapy mode. The condition of the gum and oral hygiene was evaluated clinically and objectified indexically (BoP, OHI-S) at 3 observation points: initially, 7 and 28 days after the start of observation.
Results. Based on the results of a short-term clinical study, a reliable anti-inflammatory and anti-plaque effect of spray against gum bleeding «DentaBalance®» synbiotic complex was determined. The anti-inflammatory effect was objectified by a significant decrease in the BoP index by 44.7% on the 7th day and by 33.5% additionally on the 28th day of observation. The cleansing effect on the OHI-S index increased from 16.87% on the 7th day of observation to 55.41% at its final stage. The expediency of using spray against gum bleeding «DentaBalance®» synbiotic complex in the complex treatment of CSMG is pathogenetically substantiated, the advantages and prospects of its use in periodontal practice are established.
Conclusion. The effectiveness and safety of the spray against gum bleeding «DentaBalance®» synbiotic complex including lysate from Streptococcus Thermophilus and prebiotics for hygienic oral care and effective relief of gum inflammation symptoms in patients with CSMG has been pathogenetically substantiated and clinically proven.
PRE-IMPLANTATION GINGIVAL HISTOPATHOLOGICAL CHANGES: CLINICAL CASE SERIES
Authors: Kulikov Alexey , Zhad'ko Sergey , Romanenko Inessa , Kriventsov Maksim 
Published: August 2023

An inflammatory process in the gingival and/or periodontal tissues prior to implantation seems to be a significant risk factor contributing to impaired osteointegration with implant rejection in the early or late stages due to the development of periimplantation mucositis followed by periimplantitis. In this regard, the task of searching for highly informative markers, both morphological and laboratory, as well as molecular genetic markers, remains extremely relevant, allowing predicting the risk of developing periimplantitis in various populations. An equally urgent task is the search for effective means of adjuvant therapy and prevention of inflammatory complications after dental implantation. The aim of this study was a comprehensive histopathological assessment of the state of the gingiva by biopsy at the stage before implantation in a clinical case series.
In a clinical case series (25 patients), using a descriptive histological method, a histopathological analysis of gingival biopsy samples obtained at the stage of implant placement was performed. The data of the descriptive histological analysis were supplemented by the results of an immunohistochemical study for the expression of vitamin D receptors (VDR) in the gingival tissues and inflammatory infiltration cells.
According to the results of a descriptive histopathological analysis, in 7 out of 25 cases (28%) in the gingival tissues of the edentulous area of the jaw in the area of the included defect of the dentition, the phenomenon of less or more pronounced chronic inflammation was revealed, manifested in lymphocytic or mixed lymphohistiocytic infiltration. Other significant histopathological changes were presented by the changes in the gingival epithelium, as well as disorders in the vessels of the microvasculature. Immunohistochemical analysis demonstrated the presence of a strong nuclear and/or cytoplasmic expression of VDR both in the epithelium and cells of the inflammatory infiltrate, regardless of the age and gender of the patients or the severity of inflammatory changes in the gingival tissues.
The results of the pilot analysis of clinical case series are of interest for further study of pre-implantation gingival or periodontal lesions, and may help identify biomarkers of the subsequent development of periimplantitis, as well also provide a fundamental rationale for the use of vitamin D as a prophylactic or therapeutic adjuvant.