bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy and Tolerability of the Use of Combined Versus Single Analgesic and Prophylactic Medications in Severe Migraine
Authors: Al-Zaubai Nuha M. Salih , Al-Anbari Husam Ghazi , Alsaady Ali A. Hadi 
Published: June 2023

Background: Migraine is a common cause of primary headaches that may interfere with normal daily activities for which different modalities of treatment had been used. In the present study different types of analgesics and prophylactic medications had been evaluated for their efficacy and tolerability.
Objective: To evaluate the efficacy and tolerability of: 1. Combined analgesic, Excedrin (aspirin with paracetamol and caffeine) in comparison with single analgesic, diclofenac, as a therapy for severe migraine attack.

Combined prophylactic, amitriptyline, or propranolol with pizotifen in comparison with pizotifen alone as prophylactic drugs for severe migraine.

Materials & Methods: Part (1): 80 patients with severe migraine were enrolled and randomly assigned to receive an oral tablet of either Excedrin (aspirin 250 mg, acetaminophen 250mg, caffeine 65mg) four times daily when needed (n=40) or diclofenac 50mg twice daily when needed as abortive treatment for migraine attack, in addition to the use of pizotifen twice a day in both subgroups for 10 days duration. Part (2): 46 patients who showed good response from part one of the study were divided randomly into three subgroups with different prophylactic regimens.

oral pizotifen 0.5mg tablet twice a day, n=16.
oral pizotifen 0.5mg twice a day with propranolol 20mg tablet twice a day, n=15.
oral pizotifen 0.5mg tablet twice a day with amitriptyline 10mg tablet once at night. n=15.

Efficacy was assessed by determining the patients' number exhibiting improvement with no or mild headache. Tolerability is no or minimal side effects or interactions.
Results: Part (1): A good response to treatment was obtained in 30% of the diclofenac group vs 85% of the Excedrin group (P<0.01). Part (2): A good response to treatment was obtained in 33.3% of the pizotifen group vs 60% of pizotifen with propranolol group (P< 0.05) vs 87.5% of pizotifen with amitriptyline group (P< 0.01).
Conclusion: Combined medications are more effective than single medications in the treatment & prophylaxis of severe migraine.
Evaluation of the Effect of Dapagliflozin on CRP Levels in Type 2 Diabetes Patients
Authors: Yosef Boshra , Kaddar Nisrin , Boubou Arige 
Published: June 2023

Type 2 diabetes mellitus (T2DM) is an increasingly prevalent chronic disease that associates with an increased risk of micro-and macrovascular complications. There is persuasive evidence that dapagliflozin may reduce chronic inflammation besides its glucose-lowering effect, which in term prevents the development of the disease and its complications. Therefore, this study aims to evaluate the effects of dapagliflozin on the inflammatory marker C-reactive protein (CRP) levels in T2DM patients. Patients with T2DM were randomly assigned into two groups, group 1 (n=52) receiving a daily dose of dapagliflozin as an add-on therapy with oral antihyperglycemic agents, and group 2 (control, n=60) who received oral antihyperglycemic agents (Metformin, Sulfonylureas, Thiazolidinediones, and Gliptins). After six months, our results showed a significant change in CRP levels from baseline after receiving dapagliflozin compared to the control. Although the reduction level of CRP was statically significant with both 5 mg and 10 mg doses, it was higher with the latter one. In addition, the reduction in CRP levels was statistically significant in both controlled and uncontrolled, but more important in uncontrolled disease. An insignificant positive correlation was seen between HbA1c and CRP on admission (r: 0.21, p: 0.1) and during the follow-up period, at 3 months (r: 0.10, p: 0.4) and 6 months (r: 0.08, p: 0.5). Our study showed that dapagliflozin has a beneficial effect on inflammation by reducing CRP levels CRP in patients with T2DM.
Antibacterial Activity of Phytochemicals in Ficus thonningii Leaves Extracts Against Some Selected Pathogenic Bacterial Prevalent in Sickle Cell Anemia
Authors: Ijoma Ikechukwu , Egbulefu Ajiwe Vincent Ishmael 
Published: June 2023

Sickle cell anemia (SCA) is caused by point mutation involving substitution of valine by glutamic acid, clinical cause of this is that SCA patients are immunocompromised hence, prone to bacterial infections. Escherichia coli, Klebsiella. pneumoniae, Salmonella typhi, Streptococcus pneumoniae and Staphylococcus aureus are some of the bacterial associated with SCA. Here we investigated the antibacterial activity of extracts of Ficus thonningii leaves used by ethnomedicinal practitioners in the management of infections in SCA patients. The antimicrobial activity was determined based on average diameter of zone of inhibition (AVDZI), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) while, structure of compounds FTH1 (Bergapten), FTH2 (Protocatechuic acid) and FTH3 (Methyl ferulate) were identified based on Nuclear Magnetic Resonance (NMR) analysis. The results indicated that the crude extracts of methanol (MCE), hexane (HCE), chloroform (CCE) and methanol-water (MWCE) had AVDZI of ≥ 12.1 ± 0.12 mm, ≥ 11.0 ± 0.00 mm, ≥ 10.2 ± 0.25 mm and ≥ 12.1 ± 0.21 mm respectively while the isolated compounds FTH1, FTH2 and FTH3 had AVDZI of ≥ 10.1 ± 0.10 mm, ≥ 9.1 ± 0.12 mm, ≥ 7.1 ± 0.24 mm respectively. The AVDZI results was tested for statistical significance using one way ANOVA and Tukey Posthoc test, and was considered significant at p < 0.05. Our findings suggested that F. thonningii leaves extracts including compounds isolated from them are potential antibacterial agent and justify their use as antibacterial prophylactics in the management of infections in SCA patients by ethnic people in Nigeria
Chronology, Terminology and Periodization of the Evolution of the Light Infantry of the Russian Empire
Authors: Ульянов И.Э. 
Published: June 2023

Автор исследует и анализирует процесс эволюции русской легкой пехоты со времени ее создания и до момента исчезновения различий между видами пехоты. На основе проведенного анализа впервые предлагается ввести периодизацию процесса этой эволюции. Привлекая ряд известных и вновь выявленных источников, автор прослеживает непрерывную последовательность и преемственность отечественных документов по обучению егерей и стрелков.
The author explores and analyzes the process of evolution of the Russian light infantry from the time of its creation until the obliteration of the distinction between types of infantry. Based on the analysis, it is proposed for the first time to introduce a periodization of the process of this evolution. Drawing on a number of well-known and newly identified sources, the author traces the continuous sequence and continuity of domestic documents on the training of rangers and shooters.
The Russian Army of the XV–XVII Centuries. An Outline of the History of Organizational Structures
Authors: Курбатов О.А. 
Published: June 2023

В очерке рассматривается эволюция организационных структур русского войска великокняжеского и царского периодов, в связи с важнейшими военными реформами. Особое внимание обращается на истоки тех или иных форм воинской организации, оговариваются границы их бытования. Отмечается, что подразделения европейского типа утвердились как основа организация вооруженных сил задолго жо петровских реформ, еще во второй трети XVII в.
The article examines the evolution of the organizational structures of the Russian army of the Grand Ducal and Tsarist periods, in connection with the most important military reforms. Particular attention is paid to the origins of certain forms of military organization, the boundaries of their existence are specified. It is noted that the units of the European type were established as the basis of the organization of the armed forces long before the reforms of Peter the Great, in the second third of the XVII century.
Garrisons of the North-West of Russia (1699–1727)
Authors: Курбатов О.А. 
Published: June 2023

На примере стратегически важнейшего региона эпохи Великой Северной войны 1700–1721 гг. – северо-западных регионов России и отвоеванных у Швеции «остзейских провинций» – в статье рассматривается процесс преобразования старой пехоты русского войска, и интеграции ее в новые структуры вооруженных сил. Основное внимание уделено истории отдельных полков – стрелецких, солдатских, морских – как в период их активного формирования (в 1706–1711 гг.), так и в процессе сведения к штатной организации 1711 года, с последующими преобразованиями до времен Петра I.
As in the case of a strategically important region of the era of the Great Northern War of 1700–1721, the north-western regions of Russia and the «Baltic provinces» conquered from Sweden, the article examines the process of transforming the old infantry of the Russian army and integrating it into the new structures of the armed forces. The primary focus is on the history of individual regiments – Marksman(if the marksmen were a specialized title, it should be capitalized, if they were another unit within the army, they should be lower case, like infantry, horsemen, etc.), soldiers, naval – both during their active formation (in 1706–1711) and in the process of being reduced to a staffing structure in 1711, with subsequent transformations until the time of Peter the Great.
A Christian Theodicy
Authors: Swinburne Richard 
Published: June 2023

This is the opening talk of the conference Christian Philosophy and Its Challenges organised by Jesuit University Ignatianum in Krakow on 20-22 September 2022 in Poland. The talk was given by Richard Swinburne, Emeritus Professor at the University of Oxford, and was later edited into this openning essay of the issue dedicated to Christian Philosophy.
JURIDICAL REVIEW THE VALIDITY OF THE AGREEMENT ON PEER TO PEER LENDING SERVICES
Authors: Umami Ariza , Rahmasari Betha , Melani Yessica 
Published: June 2023

At this time many new innovations have sprung up that were born from a combination of the financial and technology sectors, one of which is Peer to Peer Lending or online loans.
This study aims to find out how the validity of the agreement and the legal consequences that occur in Peer to Peer Lending services. Types of juridical-normative research. In terms of the validity of the agreement it remains generally regulated in article 1320 of the Civil Code, legal consequences occur if the parties to the agreement do not fulfill the terms of the agreement. So, the agreement can be cancelled. If it does not meet the subjective requirements and the agreement is null and void if it does not meet the objective conditions of an agreement.
THE CRITICAL DISCOURSE ANALYSIS OF MISTRESS IN THE CASE OF LEGAL WIFE KILLED HER HUSBAND AFFAIRS NEWS
Authors: Somba Sugianti 
Published: June 2023

Abstract
If there is a problem of infidelity, women are always admitted as inmates, and are stigmatized as other ideal women. When women, who get women become mistresses try to provide clarification on the accusations, this shows their resistance. This research has the title "Analysis of the Wife's Discourse Kills Another Ideal Woman in Tiktok Videos" aims to find out how the position of women in a text is. This research is based on the idea, in this video there are two types of women, namely the legal wife and the mistress of her husband. The type of research used is descriptive qualitative. The discourse analysis technique from Teun A van Dijk is used to view video discourse and comments through character elements, macro and micro structures, and focalization. The research results are; that not all women have the same position in a text. This means that not all women are patients, and are always the guilty party, even though they are portrayed as bad person.
Key words: Mistress, Wife, Mistress, Tiktok, Discourse

Abstrak
Jika ada masalah perselingkuhan, perempuan selalu diakui sebagai narapidana, dan distigmatisasi sebagai perempuan idaman lain lainnya. Ketika perempuan yang menjadikan perempuan sebagai selingkuhan mencoba memberikan klarifikasi atas tuduhan tersebut, ini menunjukkan perlawanan mereka. Penelitian ini berjudul “Analisis Wacana Istri Tewaskan Wanita Idaman Lain dalam Video Tiktok” bertujuan untuk mengetahui bagaimana posisi perempuan dalam sebuah teks. Penelitian ini dilatarbelakangi oleh pemikiran, dalam video ini ada dua tipe wanita, yaitu istri sah dan perempuan idaman lain suaminya. Jenis penelitian yang digunakan adalah deskriptif kualitatif. Teknik analisis wacana dari Teun A van Dijk digunakan untuk melihat wacana dan komentar video melalui elemen karakter, struktur makro dan mikro, dan fokalisasi. Hasil penelitian adalah; bahwa tidak semua perempuan memiliki posisi yang sama dalam sebuah teks. Artinya tidak semua wanita adalah pasien, dan selalu menjadi pihak yang bersalah, meskipun mereka digambarkan sebagai orang jahat.
Kata kunci: Perempuan idaman lain, Istri, Nyonya, Tiktok, Wacana
МОНІТОРИНГ ЯК СКЛАДОВА ПЕДАГОГІЧНОЇ ДІЯЛЬНОСТІ ВЧИТЕЛЯ
Authors: Хлєбнікова Таліна , Карпінська Карина 
Published: June 2023

У статті схарактеризовано основні компоненти педагогічної діяльності. Обгрунтовано сутність моніторингу й розглянуто моніторингову діяльність як складову педагогічної діяльності та виокремлено її сукупні ознаки. Визначено фактори та критерії кваліметричної моделі оцінки якості моніторингової діяльності вчителя.
БІОАКУМУЛЯЦІЯ ВАЖКИХ МЕТАЛІВ В ЗЕРНІ КОЛОСОВИХ КУЛЬТУР
Authors: Бондарева Ольга , Вінюков Олександр , Чугрій Ганна 
Published: June 2023

Показники акумулятивної здатності до важких металів зерна пшениці озимої залежать від особливостей сорту: мінімальне накопичення свинцю відмічене для сортів Донецька 48, Перемога, Білосніжка, Епоха. Накопичення важких металів в зерні ячменю ярого характеризується меншою мінливістю в порівнянні з пшеницею озимою окрім цинку. Порівняння накопичення свинцю і кадмію в зерні пшениці озимої і ячменю ярого вказує на більшу чутливість до них ячменю ярого. В межах ячменю ярого найбільш стійким до забруднення свинцем був Донецький 14, а чутливим  Сталкер. Підбір сортів ячменю ярого і пшениці озимої стійких до накопичення важких металів дасть змогу отримувати високоякісне зерно, яке відповідає санітарно-гігієнічним і екологічним нормам.
КОНЦЕПТУАЛЬНІ ІДЕЇ ПРОБЛЕМИ ОСОБИСТІСНОЇ ЕФЕКТИВНОСТІ У ПАРАДИГМІ ПСИХІЧНОГО РОЗВИТКУ Г.С. КОСТЮКА
Authors: Дригус Марія , Фалькова Інна 
Published: June 2023

Проблема особистісної ефективності у різних системах – «Я – Я», «Я – професійна діяльність», «Я – соціум» є гостро актуальною як у особистісному, так і суспільному вимірах сучасності. Для конструктивного її становлення та розвитку нагальною є актуалізація непересічних теоретико-методологічних дослідницьких надбань фундатора сучасної вітчизняної психології Г.С. Костюка.
ОБҐРУНТУВАННЯ РОЗМІРУ САНІТАРНО-ЗАХИСНОЇ ЗОНИ ВІД ВІТРОВИХ ЕЛЕКТРОСТАНЦІЙ З ВІТРОВИМИ ЕЛЕКТРОУСТАНОВКАМИ (ВИРОБНИЦТВА ФУРЛЕНДЕР) ПОТУЖНІСТЮ 2; 2,5; 3 ТА 4,5 МВт
Authors: Семашко Петро , Думанський Вадим , Біткін Сергій , Безверха Анна 
Published: June 2023

При плануванні розміщення вітрових електростанцій (ВЕС) поблизу населених пунктів необхідно визначити відстані, на яких зберігаються допустимі рівні шуму від вітрових електроустановок ВЕС. При цьому існує думка, що чим більша електрична потужність ВЕС тим більшим повинен бути розмір санітарно захисної зони. В даній роботі представлені результати розрахунків очікуваних рівнів звуку від вітрових електроустановок (ВЕУ) потужністю 2; 2,5; 3 та 4,5 МВт на різних відстанях та визначено внесок сусідніх ВЕУ у формування сумарного рівня звуку в розрахунковій точці.Встановлено, що розмір санітарно-захисної зони (СЗЗ) з умов шуму від ВЕС не залежить від сумарної електричної потужності станції, а залежить від акустичної потужності найближчої до розрахункової точки ВЕУ.
Evaluation Of Online Learning And The Impact On Learning Achievement And Student Satisfaction
Authors: Manurung Tarida Marlin Surya 
Published: June 2023

The Covid-19 pandemic has had a considerable impact on education systems throughout the world, including Indonesia. The education system must adapt, from an offline learning system to an online learning system. This results in the emergence of several impacts that affect the success and satisfaction of students. There are a number of challenges in implementing online learning in developing countries, both in terms of limited facilities and the readiness factor of human resources, both lecturers and students.. The purpose of this study was to determine the impact of the online learning system on learning success and student satisfaction. The data collection method used in this study is a survey research method. The population and samples taken were students of IBI Kesatuan, Faculty of Informatics and Tourism from semester one to semester five. Data processing and analysis methods were carried out quantitatively and descriptively. The results showed that the online learning system had a positive influence on student success in terms of the value obtained, however there were also twenty three percent of the respondents who felt that the cumulative achievement index received was relatively higher than the level of success of the knowledge gained. This shows the satisfaction obtained by students with the online learning system is relatively lower than that of the offline learning system.

Keywords: offline learning, online learning, success, satisfaction
Perancangan Sistem Evaluasi Kepuasan Pelanggan Perguruan Tinggi Vokasi Yang Sesuai Dengan Perkembangan Peraturan Terbaru di Politeknik ATI Padang
Authors: Syahmer Verra , Rahmad Dedy , Hafidzh Yafid 
Published: June 2023

Universities as provides of educational service must always provide quality services to meet the needs and desires of customers. This is to get a sense of satisfaction from customers with the services that have been provided. One way to measure and determine the level of customer satisfaction is to conduct a customer satisfaction survay. Customer satisfaction surveys can be carried out using measurement instruments, one of which is a questionnaire. To be able to find out how the level of customer satisfaction with the services provided, the quesionnaire used must be in accordance with the situasion and conditions at the time of the survey. If there is a change in the service delivery process, the satisfaction measuring questionnaire must also be changed according to the changes that occur. The suitability of the satisfaction measurement questionnaire with current conditions can provide several benefits, such as the institutions being able to provide excellent service according to their needs. And the level of customer satisfaction is one aspect of accreditation so that if the questionnaire can be prepared properly, this can help the institution to improve accreditation.
Keywords: Acreditation, Customer Satisfaction, Higher Education.
Jogos escolares de Vacaria: retrato da participação dos estudantes
Authors: Almeida Uilian Maciel , Fonseca Gerard Maurício Martins 
Published: June 2023

Os jogos escolares são competições esportivas importantes na aprendizagem dos aspectos sociais, cognitivos e culturais, produzindo benefícios para a educação aliado ao desenvolvimento do esporte na escola. O objetivo do estudo foi analisar a participação e distribuição dos estudantes com relação ao naipes, masculino ou feminino, nas modalidades esportivas em três edições dos jogos na cidade de Vacaria-RS. Foram analisadas as inscrições dos estudantes de cada escola participante nos Jogos Escolares Estaduais do Rio Grande do Sul (JERGS), de 2009 a 2011. Participaram dos jogos 20 escolas públicas, com alunos do Ensino Fundamental, na categoria infantil, com idades entre 13 e 14anos. Foram ocupadas 2.307 vagas, preenchidas por 1.123 alunos, sendo 794 alunos do sexo masculino e 329 do sexo feminino. Percebe-se que os alunos ocupam vagas em mais do que um esporte com frequência e que os meninos participam mais do que as meninas. Através do teste Qui-quadrado foi detectado diferenças significativas (p<0,05) quando comparados os anos de participação. Da mesma forma, o teste apontou uma diferença na participação maior dos meninos em relação às meninas (p<0,05). A análise estatística destacou ainda que o esporte que teve maior participação de estudantes foi o futsal. Conclui-se que o atual formato da competição não proporciona uma ampliação no número de jovens participantes ao longo do tempo e não estimula a participação feminina.
Review: Analisis Senyawa Obat Warfarin dalam Plasma Darah dengan Metode HPLC/KCKT
Authors: Nafisa Siti , Rohmah Siti , Nihan Yumareta Anggun , Nurfadhila Lina , Utami Marsah Rahmawati 
Published: June 2023

Warfarin merupakan turunan sintetik kumarin yang penggunaannya sebagai antikoagulan oral yang biasa digunakan untuk mencegah dan mengobati penggumpalan darah, profilaksis dan pengobatan emboli paru dan trombosis vena, profilaksis dan pengobatan komplikasi tromboemboli dari fibrilasi atrium atau penggantian katup jantung, serta risiko kematian dari infark miokard berulang, dan kejadian tromboemboli setelah infark miokard dapat di kurangi. Warfarin merupakan indeks terapi sempit antikoagulan oral yang apabila adanya perubahan sedikit kadar obat warfarin pada darah maka dapat terdadi perubahan respons efek. telah banyak dikembangkan berbagai teknik analitik bagi analisis kadar warfarin yang ada dalam plasma darah, contohnya seperti menggunakan High-Performance Liquid Chromatography ditambah dengan deteksi ultraviolet/fluoresensi, SFC-MS/MS, LC-MS/MS, CZE dengan deteksi ultraviolet, dan MEKC-ESI–MS. Metode uji yang digunakan untuk pemantauan Artikel Review ini memiliki tujuan sebagai tinjauan dan perbandingan metode analisis/teknik pendeteksian yang digunakan pada analisis warfarin yang ada dalam plasma darah. Metode HPLC memiliki beberapa keuntungan dalam analisis kadar obat warfarin, yaitu seperti kemudahan, keakuratan, efektifitas waktu analisa, serta keunggulan sensitivitas dan selektivitas yang tinggi.
Factors Related to Anxiety in Hemodialysis Patients in Malang City, Indonesia
Authors: Ubaidillah Zaqqi , Kurnia Anggraini Dwi , Fiqri Izzul 
Published: June 2023

Objective: This study aimed to determine the factors associated with anxiety in hemodialysis patients.
Methods: This study used a cross-sectional design. An accidental sampling technique was used to obtain a total sample of 34 respondents. The data were analyzed using Fisher’s exact test.
Results: Based on the results of statistical tests, it is known that the level of anxiety related to hemodialysis patients, namely hemodialysis duration with Fisher's exact (P= 0.020). While the hemodialysis time value (P= 0.173, and work status value (P = 0.080), there was no association with the anxiety of hemodialysis patients.
Conclusion: This study concluded that the duration of hemodialysis was related to the anxiety of hemodialysis patients, whereas there was no result in hemodialysis and occupational status related to the incidence of anxiety in hemodialysis patients. Therefore, healthcare providers should concern about the duration of hemodialysis time to prevent anxiety.