bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of metabolic syndrome predictors in relation to inflammation and visceral fat tissue in older adults
Authors: Tylutka Anna , Morawin Barbara , Walas Łukasz , Michałek Marta , Gwara Anna , Zembron-Lacny Agnieszka 
Published: January 2023

AbstractThe diagnosis of metabolic syndrome (MetS) focuses on the assessment of risk factors such as insulin resistance, dyslipidemia, central adiposity and elevated blood pressure. Evidence suggests that markers of systemic inflammation may also be included in the definition of MetS and play some role in its pathogenesis. The study was designed to evaluate low-grade inflammation status in older adults with MetS in relation to increased body fat tissue and an attempt was made to evaluate new predictors for MetS through the analysis of the ROC Curve. Ninety-six middle-aged (69.2 ± 4.9) individuals from University of Third Age (women n = 75 and men n = 21) were allocated to two groups: without metabolic syndrome (n = 37) and with metabolic syndrome (n = 59) according to International Diabetes Federation criteria in agreement with American Heart Association/National Heart, Lung and Blood Institute 2009. Participants’ current health status was assessed using medical records from a routine follow-up visit to a primary care physician. Statistical analysis was performed using R studio software. Depending on the normal distribution, ANOVA or the Kruskal–Wallis test was used. The optimal threshold value for clinical stratification (cut-off value) was obtained by calculating the Youden index. The AUC was observed to be the highest for a new anthropometric index i.e. lipid accumulation product (0.820). Low-grade inflammation dominated in MetS group (BMI 28.0 ± 4.4 kg/m2, WHR 0.9 ± 0.1, FM 24.7 ± 7.9 kg) where significantly higher values of TNF-α (p = 0.027) and HGMB-1 protein (p = 0.011) were recorded.The optimal threshold values for immunological indices assessed as new predictors of the metabolic syndrome were: 93.4 for TNF-α, 88.2 for HGMB-1 protein and 1992.75 for ghrelin. High AUC values for these indices additionally confirmed their high diagnostic usefulness in MetS.
Application value of whole exome sequencing in screening and identifying novel mutations of hypopharyngeal cancer
Authors: Yao Jingwei , Ding Yubo , Liu Xiong , Huang Jialu , Zhang Minghui , Zhang Yu , Lv Yufan , Xie Zhuoyi , Zuo Jianhong 
Published: January 2023

AbstractThe research on targeted therapy of hypopharyngeal cancer is very scarce. The discovery of new targeted driver genes will promote the progress of hypopharyngeal cancer therapy to a great extent. In our research, whole-exome sequencing in 10 patients with hypopharyngeal cancer was performed to identify single nucleotide variations (SNVs) and insertions and deletions (INDELs). American College of Medical Genetics and Genomics (ACMG) guidelines were used to evaluate the pathogenicity of the selected variants. 8113 mutation sites in 5326 genes were identified after strict screening. We identified 72 pathogenic mutations in 53 genes according to the ACMG guidelines. Gene Ontology (GO) annotation and KEGG enrichment analysis show the effect of these genes on cancer. Protein–protein interaction (PPI) was analyzed by string online software. The validation results of the ualcan database showed that 22 of the 53 genes may be related to the poor prognosis of patients with hypopharyngeal cancer. RBM20 has the most significant correlation with hypopharyngeal cancer, and it is likely to be the driver gene of hypopharyngeal cancer. In conclusion, we found possible therapeutic targets for hypopharyngeal cancer, especially RBM20 and KMT2C. Our study provides a basis for the pathogenesis and targeted therapy of hypopharyngeal cancer.
Analysis of magnetic pole loss and heat in a tubular hydro‐generator based on 3D electromagnetic field–thermal network modelling
Authors: Hu Wen‐hao , Xie Jia‐qi , Zhou Zhi‐ting , Fan Zhen‐nan , Yang Yong , Dong Xiu‐cheng , Gu Shi‐fu , Li Jing‐can 
Published: January 2023

AbstractIn order to more accurately and efficiently determine the loss and heating state of the magnetic pole area of a tubular hydro‐generator, this study establishes a comprehensive 3D electromagnetic field–thermal network analysis model of its pole area and implements calculations according to its rated symmetrical operating conditions. A 36 MW large tubular hydro‐generator is used as an example. Based on the measured results of the pole temperature and the use of the calculation hardware, the results are compared with the traditional electric circuit‐magnetic circuit‐thermal circuit method and 3D electromagnetic field‐temperature field finite‐element method. It is shown that the 3D electromagnetic field–thermal network model established in this study has several advantages, including high calculation accuracy, short calculation time, and low hardware consumption. These results have important value in improving the electromagnetic–temperature analysis and design of poles in large hydro‐generators.
Fragen und die Existenz verschiedener Wahrheiten
Authors: Krause Rüdiger 
Published: January 2023

ZUSAMMENFASSUNGIn der (osteopathischen) Diagnostik und Behandlung kann es nicht
nur eine einzige Wahrheit geben. Dieses Nebeneinanderbestehen
von verschiedenen Wahrheiten verunsichert, bietet Freiheiten und
fordert Eigenverantwortung.
Recent Advances in Quinone Methide Chemistry for Protein-Proximity Capturing
Authors: Wang Rui , Gan You F. , Li Yuan Y. , Chen Xiao Q. , Guo Yu Y. 
Published: January 2023

AbstractHere we summarize the most recent findings in the chemical-, photo-, or enzyme-triggered generation of nitrogen and oxygen anions leading to the formation of quinone methide intermediates (QMIs). This short review is divided into two categories: generation of nitrogen and oxygen anions. Based on quinone methide intermediates (QMIs), proximate capture of a wide range of proteins has been widely determined and studied. Generally, the triggers include, photoirradiation using 365/254 nm UV light, small molecules (ROS/TBAF/s-tetrazine), metal catalysis (iridium catalysis), and enzymes (NQO1/β-galactosidase). New directions including far-red light, heat, force, microwave, and more practical approaches are explored and illustrated.1 Introduction2 Generation of the Nitrogen Anion3 Generation of the Oxygen Anion4 Conclusion
Characteristics, likelihood and challenges of road traffic injuries in China before COVID-19 and in the postpandemic era
Authors: Yuan Ping , Qi Guojia , Hu Xiuli , Qi Miao , Zhou Yanna , Shi Xiuquan 
Published: January 2023

AbstractThrough a review of previous studies, this paper analysed the epidemiological characteristics and attempts to determine the various trends of road traffic injuries (RTIs) in China before and after the coronavirus disease 2019 (COVID-19). This paper proposed effective measures and suggestions for responding to RTIs in China. Moreover, this paper aimed to provide some references for studies on RTIs in the future. According to a reference review, 50 articles related to RTIs were published and viewed in the China National Knowledge Infrastructure (CNKI), Wanfang database, Weipu (VIP) database and PubMed/MEDLINE database. Articles were selected according to the exclusion and inclusion criteria and then classified and summarized. Regarding cases, RTIs in China were highest in summer, autumn, and in rural areas and lowest in February. Men, elderly individuals and people living in rural areas were more susceptible to RTIs. In addition, thanks to effective and proactive policies and measures, the number of RTIs and casualties in China has substantially decreased, while there has been a growing number of traffic accidents along with the increase in nonmotor vehicles. However, it is worth noting that the number of RTIs obviously fell during the COVID-19 pandemic due to traffic lockdown orders and home quarantine policies. Nevertheless, accidents related to electric bicycles increased unsteadily because of the reduction in public transportation use at the same time. The factors that cause RTIs in China can be divided into four aspects: human behaviours, road conditions, vehicles and the environment. As a result, measures responding to RTIs should be accordingly proposed. Moreover, the road traffic safety situation in developing countries was more severe than that in developed countries. RTIs in China showed a downward trend attributed to road safety laws and various policies, and the downward trend was more significant during the COVID-19 pandemic owing to traffic lockdowns and home quarantine measures. It is urgent and necessary to promote road traffic safety, reduce injuries, and minimize the burden of injuries in developing countries.
Ultra-high vacuum compatible full metal atom beam shutter for optical lattice clocks
Authors: Park Chang Yong , Lee Won-Kyu , Heo Myoung-Sun , Yu Dai-Hyuk , Kim Huidong 
Published: January 2023

We developed a shutter driven by a solenoid to switch on/off the atomic beam of optical lattice clocks developed at KRISS [C. Y. Park et al., Metrologia 50, 119 (2013), S. Lee et al., New J. Phys. 18, 033030 (2016), H. Kim et al., Jpn. J. Appl. Phys. 56, 050302 (2017), and H. Kim et al., Metrologia 58, 055007 (2021)]. The shutter design was focused on long lifetime and compatibility with an ultra-high vacuum (UHV) environment. Thus, the solenoid was designed to be easily installed and removed from the air-side of a CF flange of the shutter. The flag in the vacuum-side moves only with the simple spring action of a sheet of a metal plate without any frictional movement of mechanical parts. All parts in the vacuum-side were made of metals (stainless steel and pure iron) to be baked over the temperature of 200 °C for UHV. The flag head of the shutter displaces up to 10 mm (5 mm) with a response time of 50 (30 ms) and 80 ms (10 ms) for the opening-action and the closing-action, respectively. The lifetime was tested up to 6 × 106 cycles with no performance degradation. We expect the actual lifetime to be much longer than this by virtue of its friction-free design.
Oxidative stability of milk and expression of oxidative stress response, lipogenic-related, and IGF-1 genes in early-lactation cows supplemented with peanut and sunflower oils
Authors: Rufino Marcelo de Oliveira Alves , Vieira Salles Márcia Saladini , Negrão João Alberto , Chaves Gurgel Antonio Leandro , Daniel João Luiz Pratti , Soares de Lima Luciano , de Marchi Francilaine Eloise , Roma Júnior Luiz Carlos , Santos Geraldo Tadeu dos 
Published: January 2023

Context Feeding dairy cows with plant oils rich in unsaturated fatty acids is a recommended strategy for increasing the proportion of polyunsaturated fatty acids in milk for human consumption. Aims We evaluated the effects of supplementation with peanut oil (high oleic acid content) and sunflower oil (high linoleic acid content) on the fatty acid profile and oxidative stability of milk and the expression of oxidative stress response, lipogenic-related and insulin-like growth factor 1 (IGF-1) genes in pasture-fed Jersey cows in early lactation. Methods Twenty-four cows were distributed in a randomised block design. Treatments were four dietary supplements of concentrate alone, or concentrate plus oil (59.6 g/kg dry matter): peanut oil, sunflower oil, or a 1:1 (v/v) mixture of peanut and sunflower oils. Analyses were performed at 30 and 60 days in milk. Key results Both peanut oil and mixed oil diets increased the hypocholesterolemic/hypercholesterolemic ratio (P < 0.001) and health-promoting index (P < 0.001) of milk. The sunflower oil diet increased the thrombogenicity index (P = 0.005) and conjugated diene production (P < 0.001). mRNA abundance of fatty acid synthase (P = 0.003), acetyl-CoA carboxylase alpha (P = 0.001), and stearoyl-CoA desaturase (P < 0.001) decreased with the sunflower oil diet. mRNA abundance of superoxide dismutase decreased (P = 0.01) with sunflower oil and mixed oil diets. The control diet tended (P = 0.08) to reduce IGF-1 mRNA abundance. Conclusions and implications Supplementation with peanut oil increases the health-promoting index of milk, whereas supplementation with sunflower oil increases susceptibility to lipid peroxidation. Supplementation with sunflower oil reduces the expression of lipogenic and antioxidant enzyme genes, and supplementation with unsaturated fats may reduce IGF-1 gene expression in early-lactation cows. The relatively small sample size means that more studies are needed.
Evaluation of the productivity and feed value of Wondergraze and Redlands leucaena cultivars under grazing
Authors: Charmley E. , McSweeney C. S. , Bishop-Hurley G. J. , Simington J. , Padmanabha J. , Giacomantonio P. 
Published: January 2023

Context Leucaena leucocephala (leucaena) is a leguminous shrub used for beef grazing in low-rainfall regions (<600–700 mm). Newer cultivars have the potential to extend adoption of the species to higher rainfall (>600–700 mm), frost-free areas of Australia. Aim We compared productivity, nutritional value and animal performance of two leucaena cultivars, new psyllid-resistant Redlands and the 2010-released Wondergraze, under continuous grazing management in a higher rainfall environment. Methods Growing steers were allocated to replicated established stands of Wondergraze or Redlands with inter-row mixed grass–legume pasture from January to July 2021. Pasture and leucaena were characterised for biomass and nutritive characteristics. Botanical composition was measured. Liveweight gain, rumen fermentation, and leucaena mimosine breakdown products were measured in grazing steers. Key results At the beginning of the study, leucaena edible biomass was similar for both cultivars (P > 0.05), but at subsequent samplings, biomass of Redlands was lower than of Wondergraze (P < 0.01). Biomass of both cultivars declined rapidly over the grazing period. Pasture biomass increased between February and July and was significantly higher in Wondergraze paddocks (P < 0.05). Animal performance was not significantly different between cultivar treatments, averaging 0.8 kg/day, but declined over time. Patterns of mimosine conversion to DHP isomers and their conjugation were similar for the two cultivars, suggesting that effectiveness of detoxification did not differ between them. Conclusion The results demonstrate that leucaena can sustain high levels of animal performance when included in tropical grass pastures in a higher rainfall environment if present in a sufficient quantity (>2 t leucaena edible dry matter/ha established leucaena). Implications Grazing leucaena–grass pastures is an effective means of increasing animal productivity in parts of subtropical Australia. However, managing grass and/or leucaena growth to match animal requirements can be challenging.
Plurilingual education
Authors: Cerezo Herrero Enrique , García-Bellido María Rosario 
Published: January 2023

AbstractThe emergence of bilingual education in the Spanish educational landscape has spawned the implementation of a great deal of Content and Language Integrated Learning (CLIL) programs. The need to raise the citizens’ proficiency of foreign languages is imperative so as to embrace the new European mandates in linguistic matter. Each region has implemented its own programs based on the linguistic reality and convictions surrounding it. In fact, the great number of research studies carried out thus far bears witness to the ever-increasing attention that this new form of education awakens in the scientific community. However, as far as the region of Valencia is concerned, despite it being a bilingual region with a long-standing tradition in the implementation of bilingual programs, we know little about the effects of such programs. The only thing that can be ascertained to date is that the road to plurilingual education has been a bumpy one due to the continuous changes in law that plurilingual education has undergone. With this in mind, this article carries out an analysis of the Valencian plurilingual system from the viewpoint of in-service teachers with a special focus on English. The results of this study are thus expected to shed some light on how the plurilingual project is playing out and to push forward the plurilingual agenda of the region.
A combined study on structural, magnetic and specific heat on double perovskite iridates Ln2CoIrO6 [Ln = Pr, Nd]
Authors: Datta Raktim , Pradhan Suman Kalyan , Saha Rafikul Ali , Kumar Ravi , Majumdar Subham , De Subodh Kumar 
Published: January 2023

Abstract
We report rich magnetic behavior for Co–Ir based double perovskites consisting of different rare earth cations Pr and Nd: Pr2CoIrO6 (PCIO) and Nd2CoIrO6 (NCIO). Both oxides show an antisite disorder of 10% and a ferrimagnetic transition, T

F
i
M

around 96 K and 98 K respectively. The long range magnetic ordering is arising from the canted antiferromagnetic ordering between the Co2+ and Ir4+ ions. A prominent peak around 27 K in magnetization data of NCIO indicates that the total moment of Nd ion is antiferromagnetically coupled to the Co–Ir sublattice. The long range order of the Nd sublattice is corroborated by the evidence of an anomaly in specific heat at very low temperature. The compounds exhibit a maximum change of magnetic entropy of 0.57 (0.48) J kg.K−1 at T

F
i
M

in a magnetic field of 5 T. The strong spin–orbit coupling in 5d states of Ir and cation disorder lead to the Mott insulating phase as found from the analysis of temperature dependent resistivity. These unique behaviors suggest an interesting interplay between localized Pr/Nd-4f, itinerant Co-3d and Ir-5d electrons.
Development of a dual-mode electro-hydrostatic actuator with serial-parallel hybrid configured piezoelectric pumps
Authors: Ling Jie , Chen Long , Zhang Mingming , Zhu Yuchuan 
Published: January 2023

Abstract
Smart materials-based electro-hydrostatic actuator (EHA) plays an important role in the power-by-wire technology for the next generation of more electric aircraft. However, the output flow of a smart materials-based EHA is relatively low to narrow down its practical applications. To address this issue, a piezoelectric material-based dual-mode electro-hydrostatic actuator (DMEHA) is proposed in this work. The output flow can be improved by adopting two piezoelectric pumps without sacrificing the carrying capacity. In addition, a hybrid serial and parallel configuration for the two pumps is realized for the adaptability of different actuation requirements. Mathematical modeling and parameter identification are conducted and presented in detail for the designers. A physical prototype is fabricated and a series of experiments are carried out to investigate its characteristics. Results indicated that the DMEHA achieves a maximum output flow of 1.17 l min−1 at 360 Hz under the serial mode and the blocking load up to 40 kg. The corresponding maximum output flow in the parallel mode can reach 1.96 l min−1 at 420 Hz, and the blocking load is 20 kg.
Piezoelectric performance of lead-free PDMS/CNT/BaTiO3 piezocomposites with imperfect interphases and CNT agglomerations
Authors: Cañamero Francisco J , Buroni Federico C , Aliabadi Ferri M H , Rodríguez-Tembleque Luis 
Published: January 2023

Abstract
Three-dimensional (3D) printable lead-free piezocomposites offer scalable and environmentally friendly solutions in many engineering applications. Typically, the composite system consists of polymeric matrices reinforced with active polycrystalline particles, and possibly nanoadditives. The presence of interfacial inclusion/matrix damage could not only compromise the structural integrity of the component but also significantly alter its ability to act as functional smart materials. In addition, both the agglomeration of the nanoadditives, such as carbon nanotubes (CNTs), and the degree of polarization could also affect the electromechanical behavior of the composite. In this paper, we develop a computational micromechanical model for the study of the influence of three types of internal defects on the piezoelectric performance of such composites. We investigate the influence of (a) the texture of the active phase, which is linked to the degree of polarization; (b) the effect of agglomerations of the CNTs; and (c) the presence of damage in the inclusion/matrix interphase region. Performance is assessed through the macroscopic response in various figures of merit. This work provides numerical evidence that the effective piezoelectric constants related to normal strain modes are strongly affected by the presence of damage in the interphase. Instead, the piezoelectric constant related to the shear strain remains unchanged by interfacial damage. Near the percolation threshold of the CNTs, piezocomposites exhibit a notable improvement in the piezoelectric response compared to the composite without nanomodification, as noted in previous works. Interestingly, this trend also applies in the presence of interfacial damage, and it is described in this work. The piezoelectric performance also depends on the texture of the active particles. We find, under some simplifications, the optimal orientation for the crystallites, and we find how the texture changes the performance in the presence of damage. Regarding energy harvesting applications, optimal energy conversion efficiency has been observed for polycrystalline inclusions that resembles a highly oriented single crystal and CNT volume fraction of 60

%

of percolation threshold. This is a quite surprising result since the optimal is usually expected for volume fractions very close to percolation and active inclusions with some orientational dispersion. The optimal CNT volume fraction depends on the presence of interfacial damage. Under perfect interface conditions, the energy conversion efficiency is improved with the presence of CNT agglomerations. Under imperfect interface conditions, there is no enhancement due to the addition of CNT.
Acoustic insulation characteristics improvement of a thick CNT-reinforced doubly-curved shell by using GPLRC and MEE composite layers
Authors: Ghassabi M , Talebitooti R 
Published: January 2023

Abstract
Noise reduction in structures and human living environments is one of the most important issues in engineering that is always given special attention. Sound insulation has always been improved using different methods, one of which is to use the properties of materials. Herewith, the aim of this paper is to take advantage of graphene-platelet reinforced composites and magneto-electro-elastic (MEE) material properties for sound attenuation. The present paper deals with the analysis of sound transmission loss (STL) through a three-layer sandwich doubly-curved shell where an MEE sheet is integrated with two nanocomposite sheets. In addition, these two nanocomposite sheets are reinforced by functionally graded (FG) distributions of CNT and graphene platelet (GPL)-reinforced composites, respectively. Firstly, the three-dimensional elasticity theory is employed to derive the governing equations of motion. Then, the vibroacoustic analysis for the resultant equations is completed according to the state space and transfer matrix method. Comparing the obtained results with the available literature discloses that the offered procedure has a high precision for structural acoustic problems. In the next step, in addition to inspecting two kinds of MEE composites, the effective parameters, such as layup configuration, FG distribution, volume fraction, weight fraction, radii of curvature, electromagnetic boundary conditions, and interphase thickness, are assessed on the STL. This assessment shows that the parameters involved in this paper are highly interdependent. Accordingly, the analysis of these parameters is done simultaneously with the aid of three- and four-dimensional plots in order that the optimal value for each parameter can be realized. As seen clearly in the outcomes, the electromagnetic boundary conditions parameters, compared to the other parameters, can much more alter the STL trend, so that a slight change in electric potential results in great change in the STL.