bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digitalising the Clearance Processes of Higher Education Institutions through the Design and Implementation of an Online Clearance System
Authors: Essel Daniel Danso , Techie-Menson Henry , Oppong Stephen Opoku , Alakuu Augustine 
Published: July 2023

Students in Higher Education Institutions (HEIs) are expected to participate in a number of important activities throughout their time in school including clearance before graduation. Clearance serves as a means of ensuring graduating students satisfy all required administrative criteria. Both students and clearing officers face a daunting task as a result of the present manual clearance procedures in most HEIs. The development of this online student’s clearance system (UEW-SOCS) was done using the agile methodology. The languages and technologies used are ASP.NET MVC 5, MSSQL 2014 and JavaScript, HTML and CSS. The result is an effective and efficient web-based application that overcomes the challenges of manual paper-based systems characterized by mundane tasks by providing a responsive interface with role-based access to ensure high security. Ultimately, this study designed and implemented a successful and effective online clearance system for Higher Education Institutions that could be a critical decision support system.
Algumas dimensões atuais da análise do comportamento aplicada
Authors: Baer Donald M. , Wolf Montrose M. , Risley Todd R. 
Published: July 2023

A análise do comportamento individual tem sido sistematicamente estudada e praticada em vários contextos, ao longo de muitos anos. Essa análise resultou em descrições de princípios comportamentais que têm sido aplicados a problemas de comportamento socialmente relevantes nos últimos anos. As pesquisas de análise do comportamento aplicada – direcionadas a investigar as variáveis que podem ser efetivas para melhorar o comportamento sob estudo – possuem características que as distinguem das tradicionais pesquisas da análise do comportamento não aplicadas, conduzidas em laboratório. O estudo precisa ser aplicado, evidenciando a importância do comportamento alterado, comportamental, apresentando medidas diretas e quantitativas do comportamento alterado, e analítico, identificando com clareza o que foi responsável pela mudança. Além disso, o estudo deveria ser tecnológico, descrevendo precisamente todos os procedimentos que contribuíram para a mudança, conceitualmente sistemático, relacionando os procedimentos empregados e os resultados identificados com os processos comportamentais básicos, e efetivo, produzindo mudanças suficientemente relevantes, e deveria demonstrar alguma generalidade, planejando e avaliando a extensão dos efeitos da aplicação ao longo do tempo, para outras situações e para outros comportamentos.Palavras-chave: análise do comportamento aplicada, delineamentos experimentais, metodologia, pesquisa aplicada, tecnologia comportamental. Nota: Referência do texto original, cuja permissão de tradução foi garantida pela editora Wiley: Baer, D. M., Wolf, M. M. & Risley, T. R. (1968). Some current dimensions of applied behavior analysis. Journal of Applied Behavior Analysis, 1(1), 91-97. Resumo e abstract foram elaborados a partir dos principais aspectos do texto; a publicação original não incluía resumo. https://doi.org/10.1901/jaba.1968.1-91.TradutoresJoão Eduardo Cattani Vilares eMarcos Spector Azoubel.
Perancangan dan penjadwalan tambang batu andesit kuari blok 2 di PT Mosa Indo Palma
Authors: Suhudi Moh , Hakim Romla Noor Noor , Melati Sari 
Published: July 2023

PT Mosa Indo Palma sudah melaksanakan operasi produksi sejak tahun 2017 dengan target peningkatan produksi pada tahun 2019, oleh karena itu untuk mewujudkannya diperlukan perencanaan dan perancangan seperti membuat permodelan lapisan batu andesit, penentuan desain akhir, perhitungan cadangan batu andesit dan volume overburden dalam batas desain akhir, perancangan tambang meliputi geometri jenjang, jalan angkut, disposal, penentuan tahapan penambangan (pushback) dan penjadwalan produksi serta penentuan kebutuhan alat mekanis. Perencanaan dan perancangan tambang pada penelitian ini menggunakan aplikasi pertambangan Geovia Surpac 6.5.1. Penyajian peta menggunakan software ArcGIS 10.5. Penelitian ini hanya terfokus pada area blok 2 di PT Mosa Indo Palma. Target produksi andesit pertriwulan adalah sebesar 60.000 m3. Pada rancangan geometri kuari dan disposal menggunakan geometri yang disarankan oleh PT Mosa Indo Palma. Hasil permodelan menunjukkan bahwa bentuk endapan andesit tersebut terdapat pada area sebesar 5,57 Ha yang mana permukaan andesit semakin ke arah utara memiliki elevasi yang semakin dalam dan semakin ke arah selatan akan semakin dangkal terhadap topografi yang ada. Diketahui ketebalan endapan bervariasi dengan ketebalan antara 25 meter sampai dengan 50 meter. Jumlah cadangan andesit sebesar 1.086.315 m3 dan overburden sebesar 1.219.726 BCM dengan stripping ratio (SR) sebesar 1,1. Pertimbangan SR mengacu pada nilai SR yang semakin kecil, semakin kecil nilai SR akan mengurangi cost yang dikeluarkan. Umur kuari blok 2 berdasarkan desain adalah 4 tahun 6 bulan. Desain disposal hanya dibuat 20% dari total overburden yang dikeluarkan karena keterbatasan lokasi. Jenis isposal yang digunakan adalah Valley Fill/Crest Dump diamana dump dibangun pada lereng. Kapasitas disposal yang disediakan adalah sebesar 356.335 LCM. Pembongkaran overburden menggunakan 2 unit Excavator Komatsu PC200 dan 4 unit dump truck Mitsubisi Fuso FM257ML sedangkan pembongkaran endapan andesit menggunakan peledakan dan pengangkutan diperlukan 1 unit Excavator Komatsu PC300 dan 3 unit dump truck Mitsubisi Fuso FM257ML.
State Responsibility During Covid-19 Pandemic In The Perspective Of The Indonesian Constitutional Law
Authors: Ardhanariswari Riris 
Published: July 2023

Abstract--Coronavirus first emerged and spread to humans from Wuhan city, China at the end of December 2019 and spread to Indonesia and became a serious concern in Indonesia since March 2020 as it was stated as a nationaloutbreak. The Indonesian Constitution asserts that the purpose of formation of the State of Indonesia is to protect the whole people of Indonesia and the entire homeland of Indonesia, to promote general prosperity, to develop the nation’s intellectual life, and to contribute to the implementation of a world order based on freedom, lasting peace and social justice. The Covid-19 pandemic is not only occurring in Indonesia, but also in other countries, and each country certainly issues different policies. The state with its authority should respond to the condition in the community, which this research is based on. This research employed a normative legal method and used secondary data as its main data. Various policies are issued by the Indonesia Government from Government Regulation in Lieu of Law No. 1 of 2020 which has become Law No. 2 of 2020, Government Regulation No. 21 of 2020 on the Large Scale Social Restriction in Coronavirus Disease 2019 (COVID‑19) Response Acceleration to technical regulations issued by ministers to solve Covid-19 related issues. The policies are certainly the implementation of the state’s responsibility to the people.Keywords- State Responsibility, Constitutional Law
Collaborative Governance in Tackling Prostitution in Pemalang Regency
Authors: Tobirin Tobirin , Nasihuddin Abdul Aziz , Pamuji Kadar 
Published: July 2023

This article is driven by the complexity of handling prostitution, from economic issues, conflicts of interest, poor communication coordination, to the absence of collaboration between stakeholders. This study aimed to analyze the implementation and obstacles of collaborative governance in dealing with prostitution in Pemalang Regency. A social-juridical research methodology through the combination of doctrinal-normative legal research and social as well as social science approaches was selected for this study, while data collection were obtained through focus group discussions and secondary data. The study results showed that the implementation of collaborative governance in handling prostitution in Pemalang Regency has not been optimal, with ineffective communication identified between stakeholders. In addition, the barriers to the collaborative process include conflicts of interest in the handling of prostitution issues that give rise to differing perceptions among the health service providers, security forces, and religious leaders; ineffective institutional design; and the reliance to the deparment in charge of handling public order. The lack of shared commitment to address prostitution issue in a planned and measurable manner in adherence to local regulations remains a challenge to be resolved.Keywords: barriers, collaborative, handling, prostitution.
An Atypical Presentation of Early Periprosthetic Infection After Cervical Disc Arthroplasty
Authors: Nigh Evan D. , Finkel Ryan A. , Sayari Arash J. , Lanman Todd H. , Baron Eli M. , Cuellar Jason M 
Published: July 2023

Case:
A 22-year-old woman with Klippel-Feil syndrome who underwent cervical disc arthroplasty (CDA) presented 3 months postoperatively with worsening neck pain and radiculopathy. Work-up was negative for infection, but single-photon emission computed tomography revealed increased metabolic activity in the vertebral body below the implant. During revision, the implant was grossly loose and multiple cultures grew Cutibacterium acnes. She was treated with an antibiotic course and conversion to anterior fusion without recurrence.

Conclusion:
This report highlights the rare presentation of an early periprosthetic infection after CDA caused by C. acnes.
Case Report of Successful Bilateral Total Knee Arthroplasty
Authors: Palumbo Brian T. , Shen Victor , Andrews Reed , Scott Richard 
Published: July 2023

Case:
A 63-year-old woman with 46-year-old bilateral cemented total knee arthroplasty (TKA) presented to our clinic for routine evaluation. She was diagnosed with idiopathic juvenile arthritis at the age of 17. Radiographically she had well-fixed implants bilaterally without bone-cement lucency. She is ambulating without a limp, pain, or an assistance aid.

Conclusion:
We report TKA implants that lasted for 46 years. Literature suggests that most TKAs can last up to 20 to 25 years, but there are few reports that document implant survivorship longer than that. Our report demonstrates the possibility of long survivorship in TKA implants.
PROTOCOL OF EXTRACORPOREAL PURIFICATION TECHNIQUES
Authors: González-Fernández María , Quílez-Trasobares Nerea , Barea-Mendoza Jesús A , Molina-Collado Zaira , Arias-Verdú Dolores , Barrueco-Francioni Jesús , Seller-Pérez Gemma , Herrera-Gutiérrez Manuel E. , Riera José Ángel Sánchez-Izquierdo 
Published: July 2023

Abstract
Extracorporeal purification techniques (EPT) are complex techniques with a growing application, yet they can induce complications. A standardized approach and strict monitoring of their application are crucial to ensure patient safety. In this protocol, we describe the main indications, modalities, vascular accesses, therapy dosage, and dynamic adjustment for EPT. Additionally, we provide management algorithms that can help professionals to facilitate the adjustment of these therapies, as well as the identification of alarms, understanding of problems, and potential solutions. The application of this protocol and the evaluation of its results through a specific registry and study (DIALYREG) aims to standardize and systematize our clinical practice to improve the quality of care for our patients.
Distinct patterns of gene expression changes in the colon and striatum of young mice overexpressing alpha-synuclein support Parkinson Disease as a multi-system process
Authors: Videlock Elizabeth Jane , Hatami Asa , Zhu Chunni , Kawaguchi Riki , Chen Han , Khan Tasnin , Yehya Ashwaq Hamid Salem , Stiles Linsey , Joshi Swapna , Hoffman Jill M. , Law Ka Man , Rankin Carl Robert , Chang Lin , Maidment Nigel T. , John Varghese , Geschwind Daniel H. , Pothoulakis Charalabos 
Published: July 2023

Abstract
Background: Evidence supports a role for the gut-brain axis in Parkinson Disease (PD). Mice overexpressing human wild type α–synuclein (Thy1-haSyn) exhibit slow colonic transit prior to motor deficits, mirroring prodromal constipation in PD. Identifying molecular changes in the gut could provide both biomarkers for early diagnosis and gut-targeted therapies to prevent progression.

Objective: To identify early molecular changes in the gut-brain axis in Thy1-haSyn mice through gene expression profiling.

Methods: Gene expression profiling was performed on gut (colon) and brain (striatal) tissue from Thy1-haSyn and wild-type (WT) mice aged 1 and 3 months using 3′ RNA sequencing. Analysis included differential expression, gene set enrichment and weighted gene co-expression network analysis (WGCNA).

Results: At one month, differential expression (Thy1-haSyn vs WT) of mitochondrial genes and pathways related to PD was discordant between gut and brain, with negative enrichment in brain (enriched in WT) but positive enrichment in gut. Linear regression of WGCNA modules showed partial independence of gut and brain gene expression changes. Thy1-haSyn-associated WGCNA modules in the gut were enriched for PD risk genes and PD-relevant pathways including inflammation, autophagy, and oxidative stress. Changes in gene expression were modest at 3 months.

Conclusions: Overexpression of haSyn acutely disrupts gene expression in the colon. While changes in colon gene expression are highly related to known PD-relevant mechanisms, they are distinct from brain changes, and in some cases, opposite in direction. These findings are in line with the emerging view of PD as a multi-system disease.
Experimental Validation of a New Self-isolated Four-port MIMO Antenna System for Heterogeneous Wireless applications
Authors: Sharma Madan Kumar , Hasan Syed Faraz 
Published: July 2023

Abstract
In this communication, a compact size quad-port MIMO antenna is presented for use in wireless networks including WLAN, Wi-MAX, LTE, UWB and 5G. Significant design challenges for MIMO antenna like size optimization and isolation improvement have been addressed in this study. A four-element self-isolated MIMO antenna is derived from single UWB antenna element. Port-isolation of the antenna is achieved by systematic placement of antenna element on the small size\(\left(25 \mathbf{m}\mathbf{m}\times 25 \mathbf{m}\mathbf{m}\right)\)substrate. The parametric optimization of the antenna is carried out for impedance bandwidth and isolation. The antenna prototype is designed, tested and validated (by comparing simulated and measured results) in this work. In-band reflection \({( \mathbf{S}}_{11}< -10 \mathbf{d}\mathbf{B})\) offered by the proposed antenna is 2 GHz – 30 GHz. Without use of any decoupling structure, the antenna port is isolated by more than − 40 dB. The antenna diversity performance is assessed by the evaluation of Envelope Correlation Coefficient (ECC), Total Active Reflection Coefficient (TARC) and 3D radiation patterns. Comparative study of the proposed antenna is carried out with recent reported literature. The proposed antenna is compact in size, offers larger fractional bandwidth (175%), increased isolation (≤ -40 dB), reduced ECC (0.003), and decreased value of TARC (≤ -20 dB).
Digital Psychosocial Follow-up for Survivors of Childhood Critical Illness: Protocol for a Systematic Literature Review
Authors: Hagen Marte Hoff , Jaccheri Letizia , Papavlasopoulou Sofia , Hartvigsen Gunnar , Sæter Thorstein 
Published: July 2023

Abstract
Background: The aim of this systematic literature review is to explore a selection of existing digital solutions for psychosocial follow-up for children who survived a critical illness with research questions based on the Population, Intervention, Comparison, and Outcome (PICO) model.
Methods: A five-stage iterative process for systematic literature review in software engineering guided by Kitchenham will be used. The Preferred Reporting Items for Systematic reviews and Meta-Analyses will guide the reporting of the review. The abstract and indexing database Scopus will be used with a search strategy based on the PICO model. The records will be managed in the software EndNote and selected by eligibility criteria based on the PICO and Study design framework. This framework is also used for extraction in the data collection process. The included studies will be assessed for risk of bias with the Mixed Methods Appraisal Tool (MMAT) and synthesized qualitatively by Braun and Clarke's six-phase thematic analysis framework and quantitatively with meta-analysis when possible. The meta-analysis will calculate the effect measures using forest plots based on the method of DerSimonian and Laird. Heterogeneity is explored with meta-regression. The robustness of the meta-analysis is assessed with sensitivity meta-analyses, and the risk of bias due to missing results in synthesis is assessed with funnel plots. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach evaluates the certainty of the evidence of the review.
Discussion: This review will inform about the existing digital psychosocial follow-ups for survivors of childhood critical illness, which can lead to improved solutions and life quality for this group.
Registration: The review is registered in the International Prospective Register of Systematic Reviews database with registration number CRD42022364703.
Determining the function of ripening associated genes and biochemical changes during tomato (Solanum Lycopersicum L.) fruit maturation
Authors: Shetty Nandini Prasad , Dorairaj Darshan , Sharma Shivangi , Mawale Kiran Suresh , Puthusseri Bijesh , Parvatam Giridhar 
Published: July 2023

Abstract

This article aimed to explore biochemical alterations and gene changes during tomato fruit development and ripening. During fruit ripening, color changes and texture softening was observed, along with an increase in the accumulation of reducing sugar and total carotenoids. Free radical content was elevated during the early stages of ripening and it declined at the later stages. Activity of α-mannosidase,β-N-acetyl hexosaminidase,and polygalacturonase was measured. qPCR experiments revealed that the α-mannosidase gene was upregulated during the breaker (1.2 fold) stages of tomato ripening, the β-N-acetyl Hexosaminidase gene was upregulated throughout the breaker (2 fold) and pink (1.2 fold)stages of tomato ripening, and the β-xylosidase gene was upregulated significantly during the breaker stage(3.9 fold) of tomato ripening. The current findings revealed that the genes α-mannosidase,β-N-acetyl hexosaminidase, ethylene-responsive factors, aminocylco propane carboxylic oxidase, pectin methylesterase, and have significant associations with textural softening which was confirmed through correlation coefficient during tomato fruit ripening.
Non-permissive CHO cells; A rapid approach for purification of recombinant Herpes Simplex Virus-1
Authors: Kelishadi Mishar , Shahsavarani Hosein , Tabarraei Alijan , Shokrgozar Mohammad Ali , Rahimi Amirabbas Rahimi , Teimoori-Toolabi Ladan , Azadmanesh Kayhan 
Published: July 2023

Abstract

Exploiting herpes simplex virus type 1 (HSV-1) has recently emerged as a new strategy to improve the treatment of patients with various cancers resistant to chemotherapy and associated with a poor prognosis due to its ability to infect tumor cells without causing harm to healthy cells. It has been suggested as a new platform for cancer therapy. Gene-modification techniques such as conventional homologous recombination or CRISPR/Cas9 system are utilized to introduce site-specific mutations in targeted viral genes. Although, the CRISPR-Cas9 system could significantly increase the efficiency of homologous recombination; nevertheless the process of purifying recombinant variants can be tedious. Here we present a rapid, innovative method using non-permissive hamster ovary (CHO) cells which is a remarkable improvement on the previously mentioned tedious process. Using this strategy, only 1–2 rounds of plaque purification would suffice. Our proposed protocol demonstrated high potential as a worthy alternative way for the current approaches of the isolation and purification of the fluorescent reporter genes-expressing recombinant HSV-1 by plaque assay using CHO cells.
FSP1 is a predictive biomarker of osteosarcoma cells’ susceptibility to ferroptotic cell death and a potential therapeutic target
Authors: Pańczyszyn Elżbieta , Saverio Valentina , Monzani Romina , Gagliardi Mara , Corazzari Marco 
Published: July 2023

Abstract
Human osteosarcoma (OS) is a relatively rare malignancy preferentially affecting long body bones which prognosis is often poor also due to the lack of effective therapies. Clinical management of this cancer basically relies on surgical removal of primary tumor coupled to radio/chemotherapy. Unfortunately, most osteosarcoma cells are resistant to conventional therapy, with the undergoing epithelial-mesenchymal transition (EMT) giving rise to gene expression reprogramming, thus increasing cancer cell invasiveness and metastatic potential. Alternative clinical approaches are thus urgently needed. The recently described ferroptotic cell death represents, in this context, an attractive new strategy to efficiently kill cancer cells, since most chemoresistant and mesenchymal-shaped tumors display high susceptibility to pro-ferroptotic compounds. However, cancer cells also evolved anti-ferroptotic strategies which somehow sustain their survival upon ferroptosis induction. Indeed, here we show that osteosarcoma cell lines display heterogeneous sensitivity to ferroptosis execution, correlating with mesenchymal phenotype, which is consistently affected by the expression of the well-known anti-ferroptotic factor FSP1. Interestingly, inhibiting the activity or expression of FSP1 will restore cancer cell sensitivity to ferroptosis. Moreover, we also found that: i) AKRs might also contribute to resistance; ii) NRF2 enhances FSP1 expression upon ferroptosis induction; iii) while p53 regulates FSP1 basal expression in OS cells. In conclusion, FSP1 expression can potentially be used as a valuable predictor marker for OS sensitivity to ferroptosis and a new potential therapeutic target.
Role of GLIS3 in thyroid development and in the regulation of gene expression in thyroid specific Glis3KO mice
Authors: Kang Hong Soon , Grimm Sara A , Liao Xiao-Hui , Jetten Anton M. 
Published: July 2023

Abstract
Loss of GLI-Similar 3 (GLIS3) function in mice and humans causes congenital hypothyroidism (CH). In this study, we demonstrate that GLIS3 protein is first detectable at E15.5 of murine thyroid development, a time when GLIS3 target genes, such as Slc5a5 (Nis), become also expressed. We further show that Glis3KO mice do not display any major changes in prenatal thyroid gland morphology indicating that CH in Glis3KO mice is due to dyshormonogenesis rather than thyroid dysgenesis. Analysis of thyroid-specific Glis3 knockout (Glis3-Pax8Cre) mice fed either a normal or low-iodine diet (ND or LID) revealed that, in contrast to ubiquitous Glis3KO mice, thyroid follicular cell proliferation and the expression of cell cycle genes were not repressed suggesting that the inhibition of thyroid follicular cell proliferation in ubiquitous Glis3KO mice is related to loss of GLIS3 function in other cell types. However, the expression of several thyroid hormone biosynthesis-, extracellular matrix (ECM)-, and inflammation-related genes was still suppressed in Glis3-Pax8Cre mice particularly under conditions of high blood levels of thyroid stimulating hormone (TSH). We further demonstrate that treatment with TSH, protein kinase A (PKA) or adenylyl cyclase activators or expression of constitutively active PKA enhances GLIS3 protein and activity, suggesting that GLIS3 transcriptional activity is regulated in part by TSH/TSHR-mediated activation of the PKA pathway. This mechanism of regulation provides an explanation for the dramatic increase in GLIS3 protein expression and the subsequent induction of GLIS3 target genes, including several thyroid hormone biosynthetic genes, in thyroid follicular cells of mice fed a LID.