bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of hydroxyapatite‐based nano‐gold and nano‐silver‐doped bioceramic bone grafts: Enhanced mechanostructure, cell viability, and nuclear abnormality properties
Authors: Demirel M. , Aslan N. , Aksakal B. , Arslan M. E. 
Published: March 2023

AbstractIn this study, nano‐gold (nAu) and nano‐silver (nAg) were doped at the molar ratios of Molar5–Molar30 to the Hydroxyapatite (HAp)‐based bioceramic bone graft synthesized by the sol–gel method. The effects of nAu and nAg on structural, mechanical, cell viability, and nuclear abnormality of the synthesized bioceramic grafts were evaluated. The chemical and morphological properties of the bone grafts after production were examined through XRD and SEM–EDX analyses and mechanical tests. To determine the biocompatibility of the bone grafts, cell viability tests were performed using human fibroblast cells. In the cytotoxicity analyses, only HAp and HAp‐nAu5 grafts did not show toxicological properties at any concentration, while HAp‐nAg5 among the nAg‐containing grafts gave the best results at the 200–100 μg/mL concentrations and showed significant cytotoxicity in human fibroblast cells. The other nAu‐containing grafts showed toxicological properties in the concentration range of 200–50 μg/mL and nAg‐containing grafts in the concentration range of 200–100 μg/mL against the negative control. The micronucleus (MN) analyses showed that the lowest total MN and L (lobbed) amounts, while the lowest total N (notched) amount, was obtained from the only HAp graft. It was found that the nAg‐doped bone grafts gave higher total MN, L, and N amounts compared to the nAu‐doped bone grafts. Furthermore, while the mean nuclear abnormality (NA) values of all grafts gave close results, the highest values were again obtained from the nAg‐doped bone grafts.
Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling
Authors: Wang Su‐Chen , Huang Yi‐Chuan , Hsiao Chih‐Cheng , Sheen Jiunn‐Ming , Huang Li‐Tung , Lo Wan‐Shan , Hsieh Hsin‐Yi , Chen Yu‐Chieh 
Published: March 2023

AbstractWith the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much. Methotrexate (MTX) plays an essential role in the success of children's ALL treatment. Since hepatotoxicity is commonly reported in individuals treated with intravenous or oral MTX, our study further examined the hepatic effect following intrathecal MTX treatment, which is an essential treatment for leukemia patients. Specifically, we examined the pathogenesis of MTX hepatotoxicity in young rats and explored the impact of melatonin treatment in protection against MTX hepatotoxicity. Successfully, we found that melatonin was able to protect against MTX hepatotoxicity.
Adipokine gremlin‐1 promotes hepatic steatosis via upregulation of ER stress by suppressing autophagy‐mediated signaling
Authors: Choi Sung Woo , Oh Heeseung , Park Seung Yeon , Cho Wonjun , Abd El‐Aty A. M. , Hacimuftuoglu Ahmet , Jeong Ji Hoon , Jung Tae Woo 
Published: March 2023

AbstractGremlin‐1 (GR1) is a novel adipokine that is highly expressed in human adipocytes and has been shown to inhibit the BMP2/4‐TGFb signaling pathway. It has an effect on insulin sensitivity. Elevated levels of Gremlin have been shown to lead to insulin resistance in skeletal muscle, adipocytes, and hepatocytes. In this study, we investigated the effect of GR1 on hepatic lipid metabolism under hyperlipidemic conditions and explored the molecular mechanisms associated with GR1 by in vitro and in vivo studies. We found that palmitate increased GR1 expression in visceral adipocytes. Recombinant GR1 increased lipid accumulation, lipogenesis, and ER stress markers in cultured primary hepatocytes. Treatment with GR1 increased EGFR expression and mTOR phosphorylation and reduced autophagy markers. EGFR or rapamycin siRNA reduced the effects of GR1 on lipogenic lipid deposition and ER stress in cultured hepatocytes. Administration of GR1 via the tail vein induced lipogenic proteins and ER stress while suppressing autophagy in the livers of experimental mice. Suppression of GR1 by in vivo transfection reduced the effects of a high‐fat diet on hepatic lipid metabolism, ER stress, and autophagy in mice. These results suggest that the adipokine GR1 promotes hepatic ER stress due to the impairment of autophagy, ultimately causing hepatic steatosis in the obese state. The current study demonstrated that targeting GR1 may be a potential therapeutic approach for treating metabolic diseases, including metabolic‐associated fatty liver disease (MAFLD).
Feedback‐induced action–outcome associations increase consumer impatience
Authors: Lin Haichao , Xu Qian , Jin Liyin 
Published: March 2023

AbstractDo various kinds of feedback influence consumer impatience? Five studies involving hypothetical and real behavioral consequences demonstrate that compared with lump‐sum feedback (i.e., feedback provided in bulk at the end), piecemeal feedback (i.e., feedback provided piece by piece in the process) increases consumer impatience (i.e., preference toward now options). This effect occurs because piecemeal feedback (vs. lump‐sum feedback) establishes a reliable action–outcome association, which activates a general action goal to induce consumers to be more action oriented, making them more eager to complete actions for outcomes in subsequent related or unrelated situations. This effect is robust regardless of whether the valence of feedback is positive or negative, whether the outcome involves gain or loss (Study 1), and whether the form of feedback is monetary or informative (Study 2). Furthermore, we show that piecemeal feedback increases consumer impatience only when it is provided at a fixed ratio rather than at a variable ratio schedule (Study 3), when it is provided directly following behaviors (Study 4), and when it is directed to actions (vs. inactions) (Study 5). These findings contribute to the action goal research and consumer impatience literature.
Effect of ozonation on biodegradability enhancement and biomethanation potential of pretreatment process wastewaters from 2G ethanol production
Authors: Sreevathsan Sivakumar , Crasta Inchara , B K Bhavana , Mudliar Sandeep Narayan 
Published: March 2023

AbstractBACKGROUNDThe production of second‐generation (2G) ethanol from lignocellulosic biomass generates large quantities of high‐strength complex wastewaters from various stages of the process. An effective pretreatment is necessary in order to overcome the low biodegradability of these wastewaters for further biomethane recovery. The present study reports the effect of ozonation on the biodegradability enhancement and biomethanation potential of complex 2G ethanol pretreatment process wastewaters, from acid (H2SO4) and alkali (NaOH) pretreatment process.RESULTSOzonation (9.33 g m−3) was performed for both acid and alkali pretreatment wastewaters at a flow rate of 10 L min−1 for 1 h. Ozonation of both wastewaters increased biodegradability index (BI) up to 36% along with minimal chemical oxygen demand (COD; 7 ± 3%), color (10 ± 4%), and toxicity (22.5 ± 7.5%) reduction. Biomethane potential tests were carried out for the control and ozonated wastewaters having BI > 0.4. The acid‐pretreatment wastewater indicated poor biomethanation potential due to high presence of sulfates (COD/SO4 ~ 3.0). However, ozonation of alkali‐pretreatment wastewater facilitated up to twofold enhancement in the cumulative methane volume, while the enhancement in the rate of methane production was found to be up to 47%. Fourier transform infrared spectroscopic analysis of control and ozonated wastewaters revealed the breakdown of complex organic molecules and aromatics to readily biodegradable intermediates. The kinetics of methane generation could be predicted by the modified Gompertz model.CONCLUSIONThe study demonstrated the efficacy of ozonation as an effective pretreatment option to facilitate biodegradability enhancement of 2G ethanol pretreatment process wastewaters. The enhancement in biodegradability was observed to enable subsequent biogas recovery via anaerobic digestion along with COD removal. © 2023 Society of Chemical Industry (SCI).
Catalytic degradation of dyes on N‐doped bioresource char and its radical and nonradical mechanism
Authors: Liu Hongyu , Wen Xin , Hu Meng , Zhang Huan , Wei Junfu 
Published: March 2023

AbstractBACKGROUNDBiochar has received much attention for disposal of aqueous organic contaminants because of its great potential in adsorption and catalysis. N‐doped rice husk biochar (N‐BC) was synthesized in this work and used to activate potassium peroxymonosulfate (PMS) to remove different types of dyes. The influence of preparation conditions of N‐BC and reactive conditions on removal rate was discussed in detail. Free radical quenching experiment and electron spin resonance were used to analyze the active species and mechanism in the reaction.RESULTSN‐BC with abundant graphitic‐N, which is the main form of N to activate PMS, can be obtained by N‐doping with carbamide at 900 °C. The removal rate for new coccine can reach nearly 100% in 30 min. Furthermore, the removal rate can still be maintained at 77.21% after reusing four times only washing with water, and it can be further promoted to 98.78% after annealing treatment at 900 °C. N‐BC has excellent applicability to different types of dyes.CONCLUSIONConsequently, the mechanism is the combination of radical (O2•−) and nonradical (1O2) oxidation. First, the preparation method in this work is relatively simple. Second, the material can adapt to a very wide pH range. Third, the material shows high efficiency at room temperature (the removal rate can reach nearly 100% in 30 min). Fourth, the material shows high efficiency with only a small amount. This study provides a new path of rapid dye water purification using biochar, with simple synthesis, wide pH range adaptability, and high efficiency with only a small amount. © 2023 Society of Chemical Industry (SCI).
Carbon/Mn3O4/SrTiO3 microsphere photocatalyst for the efficient removal of high‐concentration methylene blue from water
Authors: Zhang Chenyang , Qi Haojie , Zhang Yuping , Li Chao , Zhang Qinqin , Hu Guangzhi , Li Zaixing 
Published: March 2023

AbstractBACKGROUNDWith the development of the textile and dye industry, a large amount of dye wastewater has been discharged. Semiconductor photocatalysis has been widely used in the treatment of environmental pollution, so it is very important to study efficient, nontoxic and stable photocatalysts.RESULTSIn this study, a microspherical activated carbon/Mn3O4/SrTiO3 composite photocatalyst with high catalytic activity was synthesized using sol–gel and chemical precipitation methods. The photocatalyst was characterized through X‐ray diffraction, scanning and transmission electron microscopy, energy dispersive spectroscopy, X‐ray photoelectron spectroscopy, photoluminescence, Electrochemical impedance spectroscopy, electron paramagnetic resonance spectroscopy and photocurrent measurements, and the effects of the initial methylene blue (MB) concentration and pH on the catalytic performance of the photocatalyst were investigated. The results revealed that the MC/Mn3O4/SrTiO3 composite has large light absorbance, and it can effectively inhibit photoinduced electron–hole pair recombination. The catalyst exhibited high photocatalytic degradation activity, and the degradation efficiency of MB at 300 ppm and pH 7 reached 99% after 80 min of UV light irradiation. The photodegradation process conformed to the pseudo‐first‐order kinetic model. Recyclability experiments showed that MC/Mn3O4/SrTiO3 composite has high stability, and the degradation rate of MB is > 70% after three repeat uses.CONCLUSIONSThis work provides a new method for finding low‐cost, high‐performance materials that can be modified and put into industrial use. © 2023 Society of Chemical Industry (SCI).
Outcomes on an inpatient oncology service after the introduction of hospitalist comanagement
Authors: Morris Jensa C. , Gould Rothberg Bonnie E. , Prsic Elizabeth , Parker Nathaniel A. , Weber Urs M. , Gombos Erin A. , Kottarathara Mathew J. , Billingsley Kevin , Adelson Kerin B. 
Published: March 2023

AbstractBackgroundSmilow Cancer Hospital (SCH) introduced hospitalist comanagement to the inpatient oncology service to address long lengths of stay and oncologist burnout.ObjectiveTo determine the impact of hospitalists on inpatient quality outcomes and oncologist experience.InterventionsHospitalists were introduced to one of two inpatient oncology services at SCH. Patients were assigned to teams equally based on capacity. Outcomes on the oncologist‐led, traditional service (TS) were compared with outcomes on the hospitalist service (HS) 6 months after program implementation.Main Outcomes and MeasuresOutcomes included patient volume, length of stay (LOS), early discharge, discharge time, and 30‐day readmission rate. Mixed linear or Poisson models that accounted for multiple admissions during the study duration were used. Oncologist experience was measured by survey.ResultsDuring the study period, there were 713 discharges, 400 from the HS and 313 from the TS (p = .0003). There was no difference in demographics or severity of illness (SOI) between services. Following adjustment for age, sex, race/ethnicity, cancer type, and discharge disposition, the average LOS was 4.71 on the HS and 5.47 on the TS (p = .01). Adjusted early discharge rate was 6.22% on the HS and 2.06% on the TS (p = .01). Adjusted mean discharge time was 3:45 p.m. on HS and 4:16 p.m. on TS (p = .009). There was no difference in readmission rates. Oncologists reported less stress (p = .001) and a better ability to manage competing responsibilities (p < .0001) while working on the HS.ConclusionsHospitalist comanagement significantly improved LOS, early discharge, time of discharge, and oncologist experience without an increase in 30‐day readmissions.
ZNFX1 antisense RNA1 promotes antiviral innate immune responses via modulating ZNFX1 function
Authors: Jia Xin , Zhang Meiqi , Wang Haojia , Cheng Cuiqin , Li Qiqi , Li Yiying , Kong Lingdong , Lan Xihong , Wang Yuxi , Liang Xue , Yuan Shaochun , Wang Yao , Xu Anlong 
Published: March 2023

AbstractIncreasing evidence suggests that natural antisense transcriptional lncRNAs regulate their adjacent coding genes to mediate diverse aspects of biology. Bioinformatics analysis of the previously identified antiviral gene ZNFX1 revealed neighboring lncRNA ZFAS1 transcribed on the opposite strand from ZNFX1. Whether ZFAS1 exerts antiviral function via regulating the dsRNA sensor ZNFX1 is unknown. Here we found that ZFAS1 was upregulated by RNA and DNA viruses and type I IFNs (IFN‐I) dependent on Jak‐STAT signaling, similar to the transcription regulation of ZNFX1. Knockdown of endogenous ZFAS1 partially facilitated viral infection, while ZFAS1 overexpression showed opposite effects. In addition, mice were more resistant to VSV infection with the delivery of human ZFAS1. We further observed that ZFAS1 knockdown significantly inhibited IFNB1 expression and IFR3 dimerization, whereas ZFAS1 overexpression positively regulated antiviral innate immune pathways. Mechanistically, ZFAS1 positively regulated ZNFX1 expression and antiviral function by enhancing the protein stability of ZNFX1, thereby establishing a positive feedback loop to enhance antiviral immune activation status. In short, ZFAS1 is a positive regulator of antiviral innate immune response via regulating its neighbor gene ZNFX1, adding new mechanistic insight into lncRNA‐mediated regulation of signaling in innate immunity.
Novel FDNR, FDNC and lossy inductor simulators employing second generation voltage conveyor (VCII)
Authors: Faseehuddin Mohammad , Shireen Sadia , Herencsar Norbert , Tangsrirat Worapong 
Published: March 2023

AbstractIn this research the second‐generation voltage conveyor (VCII) is employed in the design of grounded frequency dependent negative resistor (FDNR) and Frequency dependent negative conductance (FDNC). Additionally, two lossy parallel and series R‐L inductor simulators are also designed. To the best knowledge of the authors above mentioned immittance simulators are first time implemented using VCII. The FDNR requires two VCII, two capacitors and one grounded resistor. FDNC is implemented using three VCII, three resistors and two grounded capacitors. The R‐L inductor emulators requires two VCII, two resistors and one grounded capacitor. All the presented immittance simulators do not require any kind of passive component matching. The non‐ideal gain and sensitivity analysis is conducted to study their performance under circuit parameter variations. Parasitic analysis is also done for the FDNR, FDNC and R‐L inductance simulators to study the effect of parasitic impedance on the circuit operation. To validate the designs, they are simulated in Cadence design environment using 0.18 μm process design kit (PDK) at ±0.9 V supply. Additionally, the circuits are also validated using the macro model of commercially available integrated circuit (IC) AD844. The theoretical and simulation results are found to be in close agreement.
Consumer adoption of on‐demand digital platforms: An integrated model
Authors: Lim Tze‐Yin , Lim Bibiana Chiu‐Yiong , Leong Choi‐Meng , Phang Ing Grace , Foong Weng Heng 
Published: March 2023

AbstractOn‐demand digital platforms are omnipresent in the contemporary marketplace of the digital era. The purpose of this study was to assess the factors influencing consumers’ intention to adopt on‐demand digital platforms in the context of a developing country. Based on a modified integration of the unified theory of acceptance and use of technology (UTAUT) and the social influence theory, this study contended that electronic word‐of‐mouth (eWOM) about on‐demand digital platforms shapes consumers' perceived risk and subjective norms, which, along with the other elements of UTAUT, influence their intention to use on‐demand digital platforms. A self‐administered questionnaire was developed and distributed online, yielding a total of 226 responses, which were analyzed using partial least squares structural equation modelling. The findings revealed that performance expectancy, effort expectancy, subjective norms, and perceived risk significantly affect consumers’ intention, wherein eWOM reduces perceived risk and shapes subjective norms to adopt on‐demand digital platforms. Therefore, this study contributes to the literature on consumer adoption of new‐age digital products, and in this case, on‐demand digital platforms, with implications for theory and practice in this space.
The impact of corporate social responsibility practices on employees’ engagement: The mediating role of organizational identification
Authors: Ibrahim Yasser , Ahmed Mahmoud Mohamed , Nayel Mohamed Tarek 
Published: March 2023

AbstractEmployees’ engagement is an important aspect of human resources management, which is instrumental in the organization's success. Many studies have shown that corporate social responsibility (CSR) practices have a positive impact on organizational outcomes; however, few have examined the perspectives of employees, and even fewer have concentrated on the CSR practices toward stakeholders, namely employees, customers, community, government, and environment. Here, the present study examines the direct and indirect effects of perceived CSR on employees’ engagement through organizational identification as the mediating variable. A survey of 420 employees in the hospitality industry, using the SEM method, constitutes the basis for the conceptual model analysis. The findings reveal that CSR practices and identification are essential drivers of employees’ engagement. Furthermore, the findings show that perceived CSR practices toward stakeholders, except for customers, significantly influences both organizational identification and employees’ engagement. The findings also show that organizational identification plays a key mediating role in the relationship between perceived CSR and employees’ engagement. The findings emphasize the need for five‐star hotels to consider CSR practices as a strategic instrument to build the engagement of their employees. This study discusses the theoretical and practical implications of these findings, and provides suggestions for future research.
Tubomanometry in measurement of velopharyngeal closure: A pilot study
Authors: Teixeira Miriam S. , Swarts John Douglas , Lim Audrey Y. N. , Alper Cuneyt M. 
Published: March 2023

AbstractObjectiveTo investigate the differences in velum closure pattern in people with and without a history of middle ear disease using intranasal pressure curves recorded with the tubomanometer, a Eustachian tube (ET) testing device.Study DesignCase control study.SettingTertiary referral center.Subjects and MethodsTubomanometry nasopharyngeal pressure curves from 20 controls (Group 1) and 20 people with history of otitis media (OM) and possible ongoing ET dysfunction (ETD) (Group 2 or OM/ETD group) were compared. The variables included in the analysis were: (a) ratio of signal amplitude relative to the delivered nasal pressure (C2/delivered pressure x 10); (b) time (s) to achieve maximal signal amplitude (C2‐C1); (c) duration of velum closure (s) and (d) plateau decay during the isometric contraction of the velum (C3‐C2) and (e) swallow duration (s) (C4‐C1). Statistical analysis was conducted using mixed models for the normalized values of individual characteristics.ResultsAge, race and sex distribution in each group was as follows: 24 ± 8 years, 15 whites and 12 females in Group 1; 20 ± 10 years, 19 whites and 15 females in Group 2. Group 2 demonstrated a greater velopharyngeal pressure decay (p = .13), longer swallow duration (p = .10), and longer duration of velum closure (p = .14).ConclusionThis is the first study using tubomanometry to investigate differences in velopharyngeal closure between controls and individuals with OM/ETD. Although not statistically significant, our results showed that those with OM/ETD demonstrated a longer swallow and velum closure duration, and a higher degree of leakage during velum contraction compared to controls.
Geodesics as products of one‐parameter subgroups in compact lie groups and homogeneous spaces
Authors: Souris Nikolaos Panagiotis 
Published: March 2023

AbstractWe study the geodesic equation for compact Lie groups G and homogeneous spaces , and we prove that the geodesics are orbits of products of one‐parameter subgroups of G, provided that a simple algebraic condition for the Riemannian metric is satisfied. For the group , we relate this type of geodesics to the free motion of a symmetric top. Moreover, by using series of Lie subgroups of G, we construct a wealth of metrics having the aforementioned type of geodesics.