bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does hometown connection between chairmen and CEOs improve compensation–performance sensitivity in China?
Authors: Wang Di , Wu Zhanchi , You Junjie , Zhu Bangzhu , Zhang Rongwu 
Published: February 2023

AbstractBased on a the micro dataset set of private Chinese-listed companies, this study examines the in detail the impact of hometown connections between chief executive officers (CEOs) and chairmen on CEO compensation–performance sensitivity. The empirical results suggest that a hometown connection prompts both the chairman and the CEO to pay more attention to their reputations, which improves CEO compensation–performance sensitivity. This hometown effect is more pronounced when the hometown culture is strong and the degree of marketization is high. The mechanism test reveals that an externally hierd CEO strengthens the influence of a hometown connection on CEO compensation–performance sensitivity, however, this influence weakens with increasing CEO tenure. Overall, this study enriches the literature on informal institutions and compensation contracts and provides valuable insights for company managers and policymakers in emerging markets.
Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression
Authors: Jiang Han-Kai , Ambrose Nicole L. , Chung Christina Z. , Wang Yane-Shih , Söll Dieter , Tharp Jeffery M. 
Published: February 2023

Synthetic biology tools for regulating gene expression have many useful biotechnology and therapeutic applications. Most tools developed for this purpose control gene expression at the level of transcription, and relatively few methods are available for regulating gene expression at the translational level. Here, we design and engineer split orthogonal aminoacyl-tRNA synthetases (o-aaRS) as unique tools to control gene translation in bacteria and mammalian cells. Using chemically induced dimerization domains, we developed split o-aaRSs that mediate gene expression by conditionally suppressing stop codons in the presence of the small molecules rapamycin and abscisic acid. By activating o-aaRSs, these molecular switches induce stop codon suppression, and in their absence stop codon suppression is turned off. We demonstrate, in
Escherichia coli
and in human cells, that split o-aaRSs function as genetically encoded AND gates where stop codon suppression is controlled by two distinct molecular inputs. In addition, we show that split o-aaRSs can be used as versatile biosensors to detect therapeutically relevant protein–protein interactions, including those involved in cancer, and those that mediate severe acute respiratory syndrome-coronavirus-2 infection.
Frustration, Joy, and Shards of Fact
Authors: Klann Mary 
Published: February 2023

Abstract
This paper explores the connections between archival research and teaching as an adjunct faculty member and mother. The form of the essay is an example of the “I-Search paper,” a first-person account of the research process. In I-Search papers, authors start with the “search story,” where they explain their initial research questions, then describe their “search results” in detail, including the primary sources they found, and end with a reflection on the research process. This essay is two I-Search papers in one—bringing together the experience of reading about students’ historical research experiences with the author's own version of a research story. The essay is about teaching and research and their intersections, and especially what teaching has taught the author about research. The account of the individual research experience touches on the archival experiences of frustration and boredom, and the tension between wanting to find something in the archives and coming away with something else, and ends with a reflection on how our personal circumstances can impact our research.
Personality as a Predictor of Disability in Multiple Sclerosis
Authors: Jacot de Alcântara Isabele , Voruz Philippe , Allali Gilles , Fragnoli Chloé , Antoniou Maria Paraskevi , Lalive Patrice Henri , Péron Julie Anne 
Published: February 2023

Abstract

Objective
As personality changes and personality disorders are frequently observed in multiple sclerosis (MS), personality may be a prognostic factor for this disease. The present study investigated the influence of personality on disability, progression, and treatment adherence in MS.

Method
Personality was assessed in 41 patients with Relapsing–Remitting MS (30 females; mean age = 42.63 years) using the NEO Personality Inventory—3rd edition. Disability was measured with the Expanded Disability Status Scale, and treatment adherence information was collected from the Swiss MS Cohort. Correlation, multiple linear and partial least square regressions were performed to examine relations between personality, disability, and treatment adherence in MS.

Results
After accounting for age and time since disease onset, our analysis revealed that Neuroticism (β = 0.32, p = 0.01) and its Vulnerability facet (β = 0.28, p &lt; 0.05) predicted greater disability, whereas Extraversion (β = −0.25, p = 0.04) and its Activity facet (β = −0.23, p &lt; 0.05) predicted milder disability. Regarding disability progression, correlational analysis revealed that it was negatively correlated with Extraversion (r = −0.44, p = 0.02) and the Feelings facet of Openness (r = −0.41, p = 0.03), but regressions failed to highlight any predictive links. No significant results could be demonstrated for treatment adherence.

Conclusions
Overall, our study showed that some personality traits can impact disability in MS, indicating that these should be considered in clinical practice, as they could be used to adapt and improve patients’ clinical support.
A computational framework of routine test data for the cost-effective chronic disease prediction
Authors: Liu Mingzhu , Zhou Jian , Xi Qilemuge , Liang Yuchao , Li Haicheng , Liang Pengfei , Guo Yuting , Liu Ming , Temuqile Temuqile , Yang Lei , Zuo Yongchun 
Published: February 2023

AbstractChronic diseases, because of insidious onset and long latent period, have become the major global disease burden. However, the current chronic disease diagnosis methods based on genetic markers or imaging analysis are challenging to promote completely due to high costs and cannot reach universality and popularization. This study analyzed massive data from routine blood and biochemical test of 32 448 patients and developed a novel framework for cost-effective chronic disease prediction with high accuracy (AUC 87.32%). Based on the best-performing XGBoost algorithm, 20 classification models were further constructed for 17 types of chronic diseases, including 9 types of cancers, 5 types of cardiovascular diseases and 3 types of mental illness. The highest accuracy of the model was 90.13% for cardia cancer, and the lowest was 76.38% for rectal cancer. The model interpretation with the SHAP algorithm showed that CREA, R-CV, GLU and NEUT% might be important indices to identify the most chronic diseases. PDW and R-CV are also discovered to be crucial indices in classifying the three types of chronic diseases (cardiovascular disease, cancer and mental illness). In addition, R-CV has a higher specificity for cancer, ALP for cardiovascular disease and GLU for mental illness. The association between chronic diseases was further revealed. At last, we build a user-friendly explainable machine-learning-based clinical decision support system (DisPioneer: http://bioinfor.imu.edu.cn/dispioneer) to assist in predicting, classifying and treating chronic diseases. This cost-effective work with simple blood tests will benefit more people and motivate clinical implementation and further investigation of chronic diseases prevention and surveillance program.
Oncological surgery follow-up and quality of life: meta-analysis
Authors: Wullaert Lissa , Voigt Kelly R , Verhoef Cornelis , Husson Olga , Grünhagen Dirk J 
Published: February 2023

Abstract

Background
Previous trials found that more intensive postoperative surveillance schedules did not improve survival. Oncological follow-up also provides an opportunity to address psychological issues (for example anxiety, depression, and fear of recurrence). This systematic review assessed the impact of a less intensive surveillance strategy on health-related quality of life (HRQoL), emotional well-being, and patient satisfaction.

Methods
A systematic search was conducted in PubMed/MEDLINE, Embase, Web of Science, Cochrane database, PsycINFO, and Google Scholar to identify studies comparing different follow-up strategies after oncological surgery and their effect on HRQoL and patient satisfaction, published before 4 May 2022. A meta-analysis was conducted on the most relevant European Organisation for Research and Treatment of Cancer QLQ-C30 and Hospital Anxiety and Depression Scale subscales.

Results
Thirty-five studies were identified, focusing on melanoma (4), colorectal (10), breast (7), prostate (4), upper gastrointestinal (4), gynaecological (3), lung (2), and head and neck (1) cancers. Twenty-two studies were considered to have a low risk of bias, of which 14 showed no significant difference in HRQoL between follow-up approaches. Five studies with a low risk of bias showed improved HRQoL or emotional well-being with a less intensive follow-up approach and three with an intensive approach. Meta-analysis of HRQoL outcomes revealed no negative effects for patients receiving less intensive follow-up.

Conclusion
Low-intensity follow-up does not diminish HRQoL, emotional well-being, or patient satisfaction.
Madrigal or canzona? Performing intellectual and sensual pleasure in Jacopo Tintoretto’s Women making music
Authors: Swanson Barbara 
Published: February 2023

Abstract
The vague mythological context of Jacopo Tintoretto’s Women making music (after 1566, Dresden Gemäldegalerie Alte Meister) has puzzled scholars, resulting in little consensus regarding the allegorical meaning of the work. H. Colin Slim, for example, emphasized the orderly disposition of bodies in the painting, suggesting a musical-cosmological reading of the work. Liana de Girolami Cheney, on the other hand, includes the sensual in her reading, suggesting that the painting represents the dual natures of Venus.
In this article, I build on Cheney’s dual reading of the work but focus differently on the partbooks and performance, exploring how the painting blurs lines between painting as performance, and music-making as visual experience, resulting in a painted performable image. I first demonstrate how the music in the depicted partbooks encodes two divergent ways of experiencing the painting: one characterized by learned and clever allusions in the case of Andrea Gabrieli’s madrigal Quando lieta, and the other through pleasure and the erotic in the case of the anonymous canzona napolitana Dolc’amorose. By using the partbooks as interpretative clues, I argue that the painting contributes to the Renaissance paragone between painting and music, in particular a shift away from early 16th-century associations between painting, music and reason towards a celebration of the manual, sensory and embodied acts of painting. This interpretation of the painting requires the viewer to identify the songs through a combined strategy of seeing and singing, with the painting sounding differently depending on which music the viewer performs: the intricate and elevated madrigal or the sensually pleasing canzona. Seen thus, the painting blurs lines between painting and music, visual and aural, object and performance, introducing an element of ‘play’ that decentres any one allegorical meaning.
Intimate partner violence complaints during COVID-19 lockdown in Spain: a cross-sectional and a case–control study
Authors: Sanz-Barbero Belén , Estévez-Garcia Francisco , La Parra-Casado Daniel , Lopez-Ossorio Juan J , Vives-Cases Carmen 
Published: February 2023

Abstract

Background
During the COVID-19 lockdown, a large proportion of the women exposed to intimate partner violence had to live with their abusers full-time. This study analyzes the new official complaints that were filed during the lockdown in Spain.

Methods
Data from the Comprehensive Monitoring System for Cases of Gender Violence from the Ministry of the Interior, Spain. Using logistic regression models, the complaints registered during the lockdown were compared to those registered in the previous year. Subsequently, we analysed association between the seriousness of the incident reported and the period in which the complaint was filed.

Results
Official complaints decreased by 19% during the lockdown. The probability of complaints during lockdown mainly increased when victims had a relationship with the abusers [odds ratio (OR) = 1.33] and when they lacked social support (OR = 1.22). The probability that the complaints were associated with previous jealousy (OR = 0.87), previous harassment behaviours (OR = 0.88) or the victim’s fear for minors’ safety (OR = 0.87) decreased. In addition, during lockdown increased the probability that the complaints filed were due to incidents of severe physical violence (OR = 1.17); severe psychological violence against women with minors in their charge (OR = 1.22); and severe violence due to threats (OR = 1.53) when the woman had previously suffered harassment.

Conclusions
The decrease in new complaints during the studied period and the increase in their severity evidence difficulties in seeking help due to the lockdown. In situations of confinement, it is necessary to design measures that protect women with a lack of social support, and at those who live with the aggressor.
A descriptive study of COVID-19 cases in primary and secondary schools in the Maltese islands: a nationwide experience
Authors: Cuschieri Liliana , Deguara Michelle , Bartolo Dale , Calleja Neville , Gauci Charmaine 
Published: February 2023

AbstractBackgroundAs part of the measures to contain the initial cases of Coronavirus Disease (COVID-19) in 2020, all educational facilities were closed in March 2020 and remained so for the remainder of that scholastic year. When they reopened in October 2020, most educational facilities on the Maltese islands did so with various mitigation measures in place.MethodsA Schools Contact Tracing Team (SCTT) dedicated to the management of COVID-19 cases within schools was set up and networks established between the Ministries responsible for Health and Education to facilitate timely communication and, consequently, effective contact tracing. All cases pertaining to educational facilities, be they students, teaching or non-teaching staff were assessed and managed by this Team.ResultsBetween October 2020 and June 2021, the SCTT assessed 2603 COVID-19 cases within educational facilities in Malta. The highest rate of cases overall was observed in teaching staff (56.53/1000). In 72.45% of cases, no contacts were identified as high risk and thus nobody was placed in quarantine. In 3.07% of school cases &gt;21 high-risk contacts were placed in mandatory quarantine together with their household members. Only 11% of the cases were epi-linked to another positive case within school.ConclusionsThe strong collaboration between the health and education authorities combined with strict measures observed in schools ensured that schools remained open throughout most of this pandemic. This study describes the processes by which contact tracing for COVID-19 cases in Maltese schools was carried out and analyses the data collected throughout the scholastic year 2020–21.
Investigating chirality in quorum sensing by analysis ofBurkholderia cepaciaandVibrio fischeriwith comprehensive chiral LC–MS/MS and GC–MS/MS methods
Authors: Portillo Abiud E , Dhaubhadel Umang , Horacek Ondrej , Sung Y-S , Armstrong Daniel W 
Published: February 2023

AbstractN-acyl homoserine lactones (N-HLs) are signaling molecules used by Gram-negative bacteria in a phenomenon called quorum sensing. Bacteria will detect N-HLs as a way of monitoring their population which, upon reaching a critical level, will express a specific phenotype. An example is the expression of bioluminescence by Vibrio fischeri. Most studies have not considered the chirality of these molecules nor have they used highly sensitive detection methods. Here, the production of d,l-N-HLs are monitored for V. fischeri, Burkholderia cepacia, Pseudomonas fluorescens, and P. putida, using highly sensitive tandem mass spectrometry analysis. Novel N-HLs are reported for both V. fischeri and B. cepacia, including a plethora of previously unknown d-N-HLs, including the first d-N-HLs containing oxo and hydroxy functionalities. Anomalously, N-HLs were not detected in any cultures of P. fluorescens and P. putida, which are species that previously were reported to produce N-HLs. However, it is apparent that differences in the reported occurrence and levels of N-HLs can result from (a) different strains of bacteria, (b) different growth media and environmental conditions, and (c) sometimes false-positive results from detection methodologies. Time studies of V. fischeri suggest the possibility that separate synthetic and elimination pathways exist between d- and l-N-HLs. Possible biological processes that could be the source of d-N-HL production are considered.
Fault-based probabilistic seismic hazard analysis in regions with low strain rates and a thick seismogenic layer: a case study from Malawi
Authors: Williams J N , Werner M J , Goda K , Wedmore L N J , De Risi R , Biggs J , Mdala H , Dulanya Z , Fagereng Å , Mphepo F , Chindandali P 
Published: February 2023

SUMMARYHistorical and instrumental earthquake catalogs in low strain rate regions are not necessarily indicative of the long-term spatio-temporal distribution of seismicity. This implies that probabilistic seismic hazard analysis (PSHA) should also consider geologic and geodetic data through fault-based seismogenic sources. However, it is not always clear how on-fault magnitude-frequency distributions (MFDs) should be described and, if the seismogenic layer is especially thick, how fault sources should be extrapolated down-dip. We explore these issues in the context of a new PSHA for Malawi, where regional extensional rates are 0.5–2 mm yr−1, the seismogenic layer is 30–40-km thick, the instrumental catalog is ∼60 yr long and fault-based sources were recently collated in the Malawi Seismogenic Source Model. Furthermore, Malawi is one of several countries along the East African Rift where exposure to seismic hazard is growing, but PSHA does not typically consider fault sources. We use stochastic event catalogs to explore different fault source down-dip extents and MFDs. Our PSHA indicates that hazard levels are highest for a Gutenberg–Richter on-fault MFD, even at low probabilities of exceedance (2 per cent in 50 yr), whilst seismic hazard levels are also sensitive to how relatively short (&lt;50 km) fault sources are extrapolated down-dip. For sites close to fault sources (&lt;40 km), seismic hazard levels are doubled compared to previous instrumental-seismicity based PSHA in Malawi. Cumulatively, these results highlight the need for careful fault source modelling in PSHA of low strain rate regions and the need for new fault-based PSHA elsewhere in the East Africa Rift.
Feasibility and sustainability of a school-based platform for integrated delivery of HPV vaccination with adolescent health services in Tanzania: qualitative insights from stakeholders
Authors: Rosen Joseph G , Guillaume Dominique , Mlunde Linda B , Njiro Belinda J , Munishi Castory , Mlay Davis , Gerste Amelia , Holroyd Taylor A , Giattas Mary Rose , Morgan Christopher , Kyesi Furaha , Tinuga Florian , Ishengoma Joseline , Sunguya Bruno F , Limaye Rupali J 
Published: February 2023

AbstractTo meet lofty human papillomavirus (HPV) immunization goals in Tanzania, the Ministry of Health integrated HPV vaccination with adolescent health services using a school-based approach. A qualitative study was conducted in June–July 2021, examining the feasibility and sustainability of an integrated service package, HPV Plus. In-depth interviews with 46 programme implementers (i.e. health-care workers and teachers) and planning stakeholders (i.e. government officials and school administrators) in Dar es Salaam and Njombe Regions explored enablers and constraints to HPV Plus programme implementation, including resource and staffing requirements. Two facilitators and three barriers to HPV Plus feasibility and sustainability were identified from thematic analysis of interviews. Interviewed stakeholders emphasized the programme’s feasibility, especially if the efficiencies offered by a school-based platform were optimized. Implementation facilitators included (1) optimized service delivery efficiency through a school-based platform and (2) resources saved by combining adolescent health services and HPV immunization into a single programme package. Key barriers to HPV Plus feasibility and sustainability were (1) time, space and resource constraints (e.g. commodity stockouts and challenges delivering the complete service package to large cohorts of students within allotted times); (2) human resource gaps and increased workloads within the health workforce and (3) insufficient referral mechanisms linking schools to health facilities. Scaling up HPV Plus will require proactive commodity procurement and security; resource mobilization to reach ambitious service delivery targets and close co-ordination of programme implementation with school administrators.
Vertebrae reveal industrial-era increases in Atlantic bluefin tuna catch-at-size and juvenile growth
Authors: Andrews Adam J , Di Natale Antonio , Addis Piero , Piattoni Federica , Onar Vedat , Bernal-Casasola Darío , Aniceti Veronica , Carenti Gabriele , Gómez-Fernández Verónica , Garibaldi Fulvio , Morales-Muñiz Arturo , Tinti Fausto 
Published: February 2023

Abstract
Climate change and size-selective overexploitation can alter fish size and growth, yet our understanding of how and to what extent is limited due to a lack of long-term biological data from wild populations. This precludes our ability to effectively forecast population dynamics and support sustainable fisheries management. Using modern, archived, and archaeological vertebrae dimensions and growth rings of one of the most intensely exploited populations, the eastern Atlantic and Mediterranean bluefin tuna (Thunnus thynnus, BFT), we estimated catch-at-size and early-life growth patterns from the 3rd century bce to the 21st century ce to understand responses to changes in its environment. We provide novel evidence that BFT juvenile growth increased between the 16th–18th, 20th, and 21st centuries, and is correlated with a warming climate and likely a decrease in stock biomass. We found it equally plausible that fisheries-induced evolution has acted to increase juvenile BFT growth, driving earlier maturation as a result of size-selective exploitation. Coincidently, we found limited evidence to suggest a long history of large ( &gt;200 cm FL) BFT capture. Instead, we found that the catch-at-size of archaeological BFT was relatively small in comparison with more intensive, 20th and 21st century tuna trap fisheries which operated further from shore. This complex issue would benefit from studies using fine-scale biochronological analyses of otoliths and adaptation genomics, throughout the last century especially, to determine evolutionary responses to exploitation, and further disentangle the influence of temperature and biomass on fish growth.