bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multivariate regression analysis to strength and stiffness evaluation of masonry infills
Authors: Messas Amar , Adjrad Arezki , Benyahi Karim , Bouafia Youcef 
Published: July 2023

Abstract

Reinforced concrete frames with masonry infill are widely utilized in construction worldwide. This present study aimed to investigate the behaviour of masonry infill. Firstly, the compressive strength of the masonry infill and the evaluation methods were examined, specifically prism tests and wallette tests. The study collected a substantial database, revealing that wallette tests indicate higher stiffness compared to prism tests. Based on the findings, it is recommended to employ prism tests for assessing the stiffness of masonry and wallette tests for evaluating the compressive strength of masonry. Furthermore, the study assessed the performance of 18 empirical models to identify the most suitable model for predicting the compressive strength of masonry using the two testing methods (wallette and prism). To evaluate the strength of masonry infills under horizontal loading, a database of reinforced concrete frames with masonry infills was collected. The infill responses were determined by calculating the differences between the infilled frame and the bare frame. By employing multivariate regression analysis, equations were proposed for the various parameters of the quadri-linear relationship governing the behaviour of masonry infill. A comparison of the equations proposed in this present study with those present in the literature demonstrated their reliability.
Improving ginger’s bioactive composition by combining innovative drying and extraction technologies
Authors: Dalsasso Raul Remor , Valencia Germán Ayala , Monteiro Alcilene Rodrigues 
Published: July 2023

Abstract
Ginger is known for its antioxidant, antimicrobial, and anti-inflammatory properties. Its bioactive compounds can benefit foods and active packaging formulations by extending shelf life, enhancing safety, and providing health benefits to consumers. In ginger, sesquiterpenes and phenolic compounds are the main bioactives, and drying and extraction processes directly affect them. This influence can have desirable or undesirable effects on the composition, activity, and concentration. So, it is crucial to carefully define these operations to avoid losses and enable selective extraction, resulting in tailored compositions without requiring additional steps. Considering this a field to explore, the effects of combined emergent drying and extraction technologies on ginger were investigated. Vacuum microwave drying (VMD), ultrasound (UAE) (20 or 80 oC), and microwave extraction (ME) were evaluated. Drying kinetics, powder color, extract composition, and antioxidant activity were studied. While ME demonstrated high efficiency in preserving the original compounds of fresh ginger, VMD combined with UAE (20°C) produced extracts with the highest concentration of phenolic compounds (387.6 mg.GAE/g) and antioxidant activity (2100.7 mmol.Trolox/mL) and had a low impact in the main sesquiterpenes. VMD generated shogaols by its controlled high temperatures and facilitated extracting bioactives by destroying cellular structures and forming pores. UAE extracted these compounds selectively, released them from cell structures, and reduced losses caused by volatilization and thermal degradation compared to conventional methods. These findings have significant implications, as they provide an opportunity to obtain ginger extracts with tailored compositions that can enhance the formulation of food products, active food packaging, and health-related products.
Action Goal–Dependent Attentional Bias: The Effect of Threat-of-Shock on the Perception of Affective Stimuli
Authors: Sakemoto Natsuki , Tanaka Hideyuki 
Published: July 2023

Abstract

Attentional mechanisms that prioritise threat-related stimuli usually produce deleterious effects on the performance of perceptual and motor tasks. Viewing threatening stimuli generates defensive reactions, such as freezing and fight-or-flight–like responses. Additionally, the action goal of avoiding threatening stimuli is known to deteriorate task performance ironically. With these general issues in mind, the present study examined how the alteration of action goals affects attentional bias towards threat-related stimuli during induced anxiety. The participants performed a visual-probe task in which half of them responded to a probe stimulus in hit mode and the other half in avoidant mode. The participants’ anxiety levels were manipulated using a threat-of-shock method. We found that threat conditions increased the degree of attentional bias towards negative information compared to safe conditions for the avoidance goal but had no impact for the hit action goal. The difference in behavioural goals of fight or flight, represented by hit or avoidant actions, was found to interact with state anxiety, leading to different degrees of attentional bias. Avoidance may strengthen the link between attentional bias and anxiety. These findings suggest that treatments or instructions that encourage avoiding threatening stimuli as an action mode are not effective in reducing state anxiety, at least for healthy individuals.
Yellow pond turtle peptides ameliorate inflammation and cartilage damage toxicity in papain-induced KOA rats by inhibiting COX-2 and iNOS expressions
Authors: Yan Jia-xing , Li Zuo-an , Feng Lan-jie , Shen Lu-hong , Zhang Jiu-liang 
Published: July 2023

Abstract

Objective
The drugs in the treatment of knee osteoarthritis (KOA) have significant side effects and poor effectiveness. The plastron of yellow pond turtles is rich in small peptides. As such, it might inform potentially possible to uptake and enhance KOA drug utilization. Nevertheless, the cartilage protective activity of yellow pond turtle peptides (YPTP) in KOA and associated mechanism have not been reported.
Method
We explored KOA rat cartilage protection mediated by YPTP, and its underlying mechanisms using network pharmacology (NP), animal experimentation, and molecular docking (MD) analyses.
Results
Based on our NP data, COX-2 and iNOS were the primary target proteins of YPTP in KOA. Using an animal model, we revealed that YPTP strongly suppressed contents of COX-2, iNOS, and MMP-3 while upregulating COL II to alleviate inflammation and minimize cartilage damage. In addition, MD analysis further validated the 5 YPTP-derived peptides that interacted with COX-2 and iNOS via hydrogen bonding and hydrophobic interactions. Of note, the reduced YPTP dose employed in this investigation enhanced IL-1beta contents in synovial membranes, which requires further exploration.
Conclusion
YPTP ameliorated inflammation and cartilage damage in papain-induced KOA rats by suppressing both COX-2 and iNOS expressions.
The WATCH-DM Risk Score Estimates Clinical Outcomes in Type 2 Diabetic Patients with Heart Failure with Preserved Ejection Fraction
Authors: Iwakura Katsuomi , Onishi Toshinari , Okamura Atsunori , Koyama Yasushi , Tanaka Nobuaki , Okada Masato , Fujii Kenshi , Seo Masahiro , Yamada Takahisa , Yano Masamichi , Hayashi Takaharu , Yasumura Yoshio , Nakagawa Yusuke , Tamaki Shunsuke , Nakagawa Akito , Sotomi Yohei , Hikoso Shungo , Nakatani Daisaku , Sakata Yasushi 
Published: July 2023

Abstract
Background: The coexistence of heart failure is frequent and associated with higher mortality in patients with type 2 diabetes (T2DM), and its management is a critical issue. The WATCH-DM risk score is a tool to predict heart failure in patients with type 2 diabetes mellitus (T2DM). We investigated whether it could estimate outcomes in T2DM patients with heart failure with preserved ejection fraction (HFpEF).
Methods:The WATCH-DM risk score was calculated in 418 patients with T2DM hospitalized for HFpEF (male 49.5%, age 80±9 years, HbA1c 6.8±1.0%), and they were divided into the “average or lower” (≤10 points), “high” (11-13 points) and “very high” (≥14 points) risk groups. We followed patients to observe all-cause death for 386 days (median). We compared the area under the curve (AUC) of the WATCH-DM score for predicting 1-year mortality with that of the Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score and of the Barcelona Bio-Heart Failure Risk (BCN Bio-HF).
Results: Among the study patients, 108 patients (25.8%) had average or lower risk scores, 147 patients (35.2%) had high risk scores, and 163 patients (39.0%) had very high risk scores. The Cox proportional hazard model selected the WATCH-DM score as an independent predictor of all-cause death (HR per unit 1.10, 95% CI 1.03 to 1.19), and the “average or lower” risk group had lower mortality than the other groups (p=0.047 by log-rank test). The AUC of the WATCH-DM for 1-year mortality was 0.64 (95% CI; 0.45 to 0.74), which was not different from that of the MAGGIC score (0.72, 95% CI 0.63 to 0.80, p=0.08) or that of BCN Bio-HF (0.70, 0.61 to 0.80, p=0.25).
Conclusion: The WATCH-DM risk score can estimate prognosis in T2DM patients with HFpEF and can identify patients at higher risk of mortality. It can be a useful tool for heart failure management in T2DM patients.
A transcription factor GCN4 contributes to maintaining intracellular amino acid contents under the nitrogen limiting conditions in mushroom Ganoderma lucidum
Authors: Lian Lingdan , Qiao Jinjin , Guo Xiaoyu , Xing Zhenzhen , Ren Ang , Zhao Mingwen , Zhu Jing 
Published: July 2023

Abstract
Background
Edible mushrooms, with their delightful taste and abundant protein and amino acids required by human, can be used as substitutes of meat or plant proteins in a variety of foods and beverages. Nitrogen limiting conditions promote the development of fruiting bodies in mushrooms, but are not conducive to the accumulation of amino acids. Previous study has revealed that GCN4 has a pivotal role in response to nitrogen limiting conditions in Ganoderma lucidum. But its influence on amino acid contents is nearly unknown.
Results
In this study, we found that the amino acid contents reached 120.51 mg per gram of mycelia in the WT strain under the 60 mM asparagine condition, but decreased by 62.96% under the 3 mM asparagine condition. Second, silencing of gcn4 resulted in a 54.2% decrease of amino acid contents under the 60 mM asparagine condition, especially for the essential and monosodium glutamate-like taste amino acids. However, these were more pronounced under the 3 mM asparagine condition. Third, silencing of gcn4 markedly inhibited the expression of amino acid biosynthesis and transporting genes. In addition, GCN4 enhanced the tricarboxylic acid cycle (TCA) and glycolytic pathway, and inhibited the activity of target of rapamycin complex 1 (TORC1), thus being beneficial for maintaining amino acid homeostasis.
Conclusion
This study confirmed that GCN4 contributed to maintaining the amino acid contents in mushrooms under the low concentration of nitrogen. In conclusion, our study provides a research basis for GCN4 to regulate amino acid synthesis and improve nutrition of edible mushrooms.
Oxytocin Increases Negative Cognitive Bias in Females with Eating Disorders
Authors: Burmester Victoria , Sheridan Emerie , Julius Nikita , Elliott Jordan , Thackeray Olivia , Nicholls Dasha 
Published: July 2023

Abstract

Eating disorders typically emerge in adolescence 1, a critical period for brain development and social change2, meaning interpersonal difficulties—including interpretation biases—frequently co-occur3. Oxytocin is a neuropeptide that modulates social cognition and has been particularly linked to prosocial effects4. However, to date, no study has investigated oxytocin’s effects on negative interpretation bias in adolescents with eating disorders. Here we show that adolescent females with anorexia or bulimia nervosa made more negative interpretations than controls when presented with ambiguous social scenarios. As predicted, intranasal oxytocin reduced negative interpretations, but only in participants without an eating disorder. Unexpectedly, oxytocin increased negative interpretations with a large effect in participants with an eating disorder or reaching threshold on an autism screen. Oxytocin also reduced neutral interpretations overall with a large effect. The results of this study suggest that oxytocin administration may not benefit adolescent girls with an eating disorder or autism because it increased the degree of negative interpretation of social situations in these groups compared to controls. Oxytocin may increase a negative social signal in populations with extant negative social biases, which clinical practice might benefit from addressing.
More than Human Factors in Digital Health: from iterative design to implementation science evaluation.
Authors: Gough Philip , Wang Audrey P 
Published: July 2023

Abstract

Digital health technologies often employ implementation evaluations to determine their impact on the workflow of healthcare staff. However, the intention of this is not to improve the development of the digital tool from the outset. This paper presents a case study to illustrate iterative design evaluations as an approach to improve digital tools at the development phase, and how this is integrated with implementation science evaluations. Through a user-centred design process we were able to identify specific changes to the design of digital health tools that improve the usability of work-related tasks in a health context. We contribute a framework for transitioning between development and implementation strategies, and reflections on strengths and limitations of the approaches we used in design and implementation evaluations of digital health tools.
Soft-sediment deformation structures or microbial mat structures: The description and possible origin of the “loopites” in the Mesoproterozoic Wumishan Formation, North China
Authors: Lu Kai , Bao Zhidong , Li Jin 
Published: July 2023

Abstract

Within the lower Wumishan Formation at the eastern edge of the Tai-hang Mountains in North China, a ~ 10 m stratigraphic interval contains of alternately “bright and dark” laminites, with enigmatic, cross-sectional preserved loop structures (2.5 ~ 27.5 cm in length and 0.6 ~ 12 cm in height), named as “loopites” by this study. Based on the different morphologies and formations, the loopites, composed of the cores and annulate laminations, can be divided into three different types which are type Ⅰ, Ⅱ and Ⅲ. Despite the loopites are similar to the loop beddings of soft-sediment deformation structures, we suggest that they are previously undescribed microbial mat structures (MMS). The formation of type Ⅰ is interpreted as the initial microbial mat, grows on the micro-highland of carbonate deposits, are wrapped by the subsequent microbial mats. The core is the initial microbial mat, but the micro-highland, which are formed by increased carbonate sedimentation rate, are not wrapped together. In contrast, the formation of type Ⅱ and Ⅲ is interpreted that the micro-highlands, which also can be treated as the cores and may be formed by the thrombolites, rock debris and the fragments of microbial mats lie on the flat microbial mats, are wrapped by the top-covered and underlaid microbial mats. In consequence, differing from the earthquake-induced loop beddings, the formation of loopites is due to the growth, wrapping and deposition of the microbial mats. Furthermore, the discovery and the possible formation of the loopites may provide a new type of MMS and indicate a stable, anoxic and carbonate supersaturated environment with a relatively weak hydrodynamics for microbial mats to form the annulate structures which is controlled by illumination, microtopography and hydrodynamics.
Construction of porous sodium alginate/TEMPO-oxidized cellulose composite aerogel for efficient adsorption of crystal violet dye in wastewater
Authors: Zhang Zhao , Li Kun , Dong Wenjie , Xing Lu , Wang Zihao , Zhang Xinyan , Wang Jinheng , Peng Jiaxin , Wang Jikui 
Published: July 2023

Abstract

Cationic dyes pose a serious threat to human health as one of the main constituents of wastewater used in printing and dyeing. It has become difficult to remove them effectively. Adsorption based on aerogel of biomass material has become an attractive way to solve this problem. Herein, three-dimensional porous aerogel (STA) was constructed innovatively by sol-gel method and freeze-drying with sodium alginate (SA) and TEMPO-oxidized cellulose (TOC) as raw materials under the dual cross-linking effect of Ca2+ and glutaraldehyde (GA). Multiple characterization approaches and analytical methods were used to study STA. The results indicated that the addition of TOC resulted in the excellent pore structure, thermal stability, charge characteristic and adsorption capacity of STA. The adsorption capacity of STA was investigated by selecting crystalline violet (CV) as a typical cationic dye. Thereafter, the adsorption capacity was comprehensively analyzed by varying temperature, pH and adsorption time. The adsorption process conformed to the pseudo-second-order kinetic model, and the Langmuir isothermal adsorption model has a better fit, which was a single-molecule layer chemisorption process. The highest adsorption capacity reached 505.96 mg/g. Moreover, STA also possessed outstanding competitive adsorption capacity and cyclic adsorption performance.
Investigating Narcondam offshore using high-resolution seismic reflection data
Authors: Srivas Harshad Kumar , Ghosal Dibakar 
Published: July 2023

Abstract
The Andaman Sea is a back-arc basin that hosts the active Barren and the dormant Narcondam volcanoes. Despite its geological and geophysical significance, there are limited studies conducted over offshore Andaman. Here, a geophysical study of Narcondam offshore is presented to investigate basinal deposits and associated fluids and their migration paths using a 30 km long high-resolution 2D seismic reflection. The migrated section reveals a subsurface image highlighting evidence of a bright seafloor- parallel reflector with negative polarity at a two-way time (TWT) of 2.78-2.82 s (~2.2-2.3 km) with an interval velocity of 1.56 km/s. Amplitude Versus Angle (AVA) analysis using Aki Richard's two-term equation is further conducted to characterize the reserved fluid. The AVA analysis yields an increase in amplitude with angle, providing compelling evidence of fluid presence. Additionally, the depth converted migrated seismic section exhibits indications of columnar faults of Neogene period influencing the migration of fluids within the basin.
Defining a competency framework for health and social professionals to promote healthy ageing throughout the lifespan: an international Delphi study
Authors: Rodríguez-Monforte Míriam , Fernández-Jané Carles , Bracha Marietta , Bartoszewska Adrianna , Kozakiewicz Mariusz , Leclerc Mariel , Nimani Endrit , Soanvaara Pauliina , Jarvinen Sari , Sherpenseel Meike van , Valde Miriam van der , Lopes António Alves , Handgraaf Marietta , Grüneberg Christian , Carrillo-Alvarez Elena 
Published: July 2023

Abstract

Purpose: The promotion of healthy ageing has become a priority in most parts of the world, and it should be promoted at all ages. However, baseline training of health and social professionals is currently not adequately tailored to face these challenges. This paper reports the results of a Delphi study conducted to reach expert agreement about health and social professionals’ competencies to promote healthy ageing throughout the lifespan within the SIENHA project. Materials and
Methods: This study was developed following the CREDES standards. The initial version of the competence framework was based on the results of a scoping review and built following the CanMEDS model. The expert panel consisted of a purposive sample of twenty-two experts in healthy ageing with diverse academic and clinical backgrounds, fields and years of expertise from seven European countries. Agreement was reached after three rounds.
Results: The final framework consisted of a set of 18 key competencies and 80 enabling competencies distributed across six domains.
Conclusions: The SIENHA competence framework for healthy ageing may help students, and educators, to enrich their learning, and the academic content of their subjects or/and programmes and incentivize innovation.
Effect of blastocyst shrinkage on assisted reproductive outcomes: A retrospective cohort study describing a new morphological evaluation of blastocyst pre-vitrification and post-warming
Authors: Ito Ayumo , Katagiri Yukiko , Oigawa Satoko , Amano Kenji , Ichizawa Koichiro , Tokuda Yukiko , Unagami Mami , Yoneyama Masato , Tsuchiya Takahiro , Sekiguchi Mami , Furui Mayuko , Nakaoka Kentaro , Umemura Nahomi , Hayashi Yuko , Tamaki Yuko , Nagao Koichi , Nakata Masahiko 
Published: July 2023

Abstract
Background
The failure of frozen-thawed blastocysts to re-expand adequately within a few hours after warming has been reported to have a negative impact on assisted reproductive technology (ART) outcomes. However, the extent to which this failure truly affects ART outcomes has not yet been presented in a manner that is easily understandable to medical practitioners and patients. This study aimed to assess the effects of blastocyst shrinkage on ART outcomes and determine a more effective morphological evaluation approach for use in clinical settings.
Methods
This retrospective observational cohort study of frozen-thawed blastocyst transfer cycles was conducted from April 2017 to March 2022. Overall, 1,331 cycles were eligible for inclusion, of which 999 were good-quality blastocysts and 332 were non-good-quality blastocysts. All frozen-thawed blastocyst transfer cycles performed during the specified study period were included in the study. Exclusion criteria were established to mitigate potential sources of bias as these cycles could impact implantations. We calculated rates and age-adjusted odds ratios of implantation, clinical pregnancy, ongoing pregnancy, and live birth of the re-expansion group, which showed sufficient expansion, and shrinkage group, which showed insufficient expansion. We also calculated the implantation, clinical pregnancy, ongoing pregnancy, and live birth rates of the re-expansion and shrinkage groups for each morphological scoring system parameter.
Results
A reduced ART outcome was observed with use of blastocysts with shrinkage after vitrification/warming. The age-adjusted odds ratios for implantation, clinical pregnancy, ongoing pregnancy, and live birth were lower in the shrinkage group than in the re-expansion group.
Conclusions
This study examined the adverse effect of blastocyst shrinkage after warming and recovery culturing on reproductive outcomes in a clinically useful manner by retrospectively examining a substantial number of frozen-thawed embryo transfer cycles. The study findings can possibly reduce concerns regarding over- or under-estimation of blastocyst implantation by allowing providers and patients to refer to the data.