bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sunlight perception and outdoor thermal comfort in college campuses: a new perspective
Authors: Ning Shaobo , Jing Wenqiang , Ge Zhemin 
Published: September 2023

AbstractThe thermal comfort of outdoor spaces in colleges and universities is crucial for promoting outdoor activities and relieving psychological pressure. To evaluate outdoor thermal comfort from a new perspective, this study investigated subjects' sunlight perception through physical measurements and questionnaires. Sunlight perception was delineated through a combination of subjective assessments and objective measurements. Subjective assessments encapsulated thermal comfort and sensation votes, and sunlight sensitivity. Objective measurements incorporated physical environmental data such as temperature, humidity, wind speed, illumination, and solar radiation. The Universal Thermal Climate Index (UTCI) was used to examine the thermal sensation of subjects under different sun perceptions to reveal the effect of sunshine sensitivity on subjects. The results showed that in terms of subjective perception, the proportion of people who felt hot outdoors increased with the increase in sunlight perception. Additionally, with the change of sunlight perception, the expected temperature of the crowd also changed. As the sunlight perception changed from weak to strong, the desired temperature of the winter population changed from 21.2 °C to 17.7 °C, and the desired temperature of the autumn population changed from 23.8 °C to 19.8 °C. Appropriately increasing shade outdoors in autumn would enhance the comfort of the crowd, while appropriately increasing the light place in the winter outdoors would enhance the comfort of the crowd. These findings provide valuable insights for thermal comfort design and future research in colleges located in cold areas.
Differences in the phospholipid profile of melanocytes and melanoma cells irradiated with UVA and treated with cannabigerol and cannabidiol
Authors: Łuczaj Wojciech , Dobrzyńska Izabela , Skrzydlewska Elżbieta 
Published: September 2023

AbstractUV radiation inducing mutations in melanocytes might cause melanoma. As changes in lipid composition and metabolism are associated with many types of cancer including skin cancer, we aimed to evaluate the effects of two phytocannabinoids cannabidiol (CBD) and cannabigerol (CBG), on changes in phospholipid and ceramide (CER) profiles induced by UVA irradiation in human melanocytes and melanoma. UVA radiation caused a significant up-regulation PC, PI and SM species and decrease of CERs content in both types of cells, while up-regulation of PEo was only observed in melanocytes. Exposure of UVA-irradiated melanocytes or melanoma cells to CBD and/or CBG led to significant decrease in relative content of PC, PI and SM specie; however, this effect was more pronounced in cancer cells. Interestingly, only in UVA-irradiated melanocytes and not in melanoma, PEo content was lowered after CBD treatment, while CBG led to additional up-regulation of PEo species. CBD and CBG used together caused decrease of zeta potential, inhibiting PS externalization, and different changes in relative contents of CER and SM species of irradiated and non-irradiated melanoma cells. Obtained results are quite promising due to CBD and CBG abilities to partial reverse pro-cancerogenic changes in phospholipid and CER profiles induced by UVA.
Use of biomarkers for predicting a malignant course in acute ischemic stroke: an observational case–control study
Authors: Guimarães de Almeida Barros Alexandre , Roquim e Silva Lucas , Pessoa Alberlúcio , Eiras Falcão Antonio , Viana Magno Luiz Alexandre , Valadão Freitas Rosa Daniela , Aurelio Romano Silva Marco , Marques de Miranda Debora , Nicolato Rodrigo 
Published: September 2023

AbstractAcute ischemic stroke is a sudden neurological event caused by brain ischemia. Patients with large vessel occlusion are at high risk of developing significant cerebral edema, which can lead to rapid neurological decline. The optimal timing for decompressive hemicraniectomy to prevent further brain damage is still uncertain. This study aimed to identify potential predictors of severe brain edema. The data indicate that specific cytokines may help identify patients with a higher risk of developing life-threatening brain swelling in the early phase post-stroke. The association between a positive biomarker and the outcome was calculated, and three biomarkers—S100B protein, MMP-9, and IL-10—were found to be significantly associated with malignant edema. A model was derived for early predicting malignant cerebral edema, including S100B protein and IL-1 beta. These findings suggest that molecular biomarkers related to the ischemic cascade may be a helpful way of predicting the development of malignant cerebral edema in ischemic stroke patients, potentially widening the time window for intervention and assisting in decision-making. In conclusion, this study provides insights into the molecular mechanisms of severe brain edema and highlights the potential use of biomarkers in predicting the course of ischemic stroke.
Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice
Authors: Teper Yaroslav , Ye Linda , Waldron Richard T. , Lugea Aurelia , Sun Xiaoying , Sinnett-Smith James , Hines Oscar J. , Pandol Stephen J. , Rozengurt Enrique , Eibl Guido 
Published: September 2023

AbstractPancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with limited therapeutic options, may benefit from repurposing of FDA-approved drugs in preventive or interceptive strategies in high-risk populations. Previous animal studies demonstrated that the use of metformin and statins as single agents at relatively high doses restrained PDAC development. Here, four-week-old mice expressing KrasG12D in all pancreatic lineages (KC mice) and fed an obesogenic high fat, high calorie diet that promotes early PDAC development were randomized onto low dosage metformin, simvastatin, or both drugs in combination administered orally. Dual treatment attenuated weight gain, fibro-inflammation, and development of advanced PDAC precursor lesions (pancreatic intraepithelial neoplasia [PanIN]-3) in male KC mice, without significant effect in females or when administered individually. Dual-treated KC mice had reduced proliferation of PanIN cells and decreased transcriptional activity of the Hippo effectors, YAP and TAZ, which are important regulators of PDAC development. Metformin and simvastatin also synergistically inhibited colony formation of pancreatic cancer cells in vitro. Together, our data demonstrated that a combination of low doses of metformin and simvastatin inhibits PDAC development and imply that both drugs are promising agents for being tested in clinical trials for preventing pancreatic cancer progression.
Tomato growth stage modulates bacterial communities across different soil aggregate sizes and disease levels
Authors: Dong Menghui , Kuramae Eiko E , Zhao Mengli , Li Rong , Shen Qirong , Kowalchuk George A 
Published: September 2023

Abstract
Soil aggregates contain distinct physio-chemical properties across different size classes. These differences in micro-habitats support varied microbial communities and modulate the effect of plant on microbiome, which affect soil functions such as disease suppression. However, little is known about how the residents of different soil aggregate size classes are impacted by plants throughout their growth stages. Here, we examined how tomato plants impact soil aggregation and bacterial communities within different soil aggregate size classes. Moreover, we investigated whether aggregate size impacts the distribution of soil pathogen and their potential inhibitors. We collected samples from different tomato growth stages: before-planting, seedling, flowering, and fruiting stage. We measured bacterial density, community composition, and pathogen abundance using qPCR and 16 S rRNA gene sequencing. We found the development of tomato growth stages negatively impacted root-adhering soil aggregation, with a gradual decrease of large macro-aggregates (1–2 mm) and an increase of micro-aggregates (&lt;0.25 mm). Additionally, changes in bacterial density and community composition varied across soil aggregate size classes. Furthermore, the pathogen exhibited a preference to micro-aggregates, while macro-aggregates hold a higher abundance of potential pathogen-inhibiting taxa and predicted antibiotic-associated genes. Our results indicate that the impacts of tomatoes on soil differ for different soil aggregate size classes throughout different plant growth stages, and plant pathogens and their potential inhibitors have different habitats within soil aggregate size classes. These findings highlight the importance of fine-scale heterogeneity of soil aggregate size classes in research on microbial ecology and agricultural sustainability, further research focuses on soil aggregates level could help identify candidate tax involved in suppressing pathogens in the virtual micro-habitats.
Arctic bacterial diversity and connectivity in the coastal margin of the Last Ice Area
Authors: Girard Catherine , Vincent Warwick F , Culley Alexander I 
Published: September 2023

Abstract
Arctic climate change is leading to sea-ice attrition in the Last Ice Area along the northern coast of Canada and Greenland, but less attention has been given to the associated land-based ecosystems. Here we evaluated bacterial community structure in a hydrologically coupled cryo-ecosystem in the region: Thores Glacier, proglacial Thores Lake, and its outlet to the sea. Deep amplicon sequencing revealed that Polaromonas was ubiquitous, but differed genetically among diverse niches. Surface glacier-ice was dominated by Cyanobacteria, while the perennially ice-capped, well-mixed water column of Thores Lake had a unique assemblage of Chloroflexi, Actinobacteriota, and Planctomycetota. Species richness increased downstream, but glacier microbes were little detected in the lake, suggesting strong taxonomic sorting. Ongoing climate change and the retreat of Thores Glacier would lead to complete drainage and loss of the lake microbial ecosystem, indicating the extreme vulnerability of diverse cryohabitats and unique microbiomes in the Last Ice coastal margin.
A multivariate natural gas load forecasting method based on residual recurrent neural network
Authors: Ni Xueqing , Yang Dongsheng , Qin Jia , Wang Xin 
Published: September 2023

AbstractCurrent natural gas load forecasting encounters with the conundrum of unsatisfying accuracy and interpretability. To address the challenge, a multi‐variate forecasting method is proposed, which contains three phases: First, an integrate history‐climate‐holiday factor set is established to provide multi‐perspective for a more explainable forecast; Second, factor fusion interaction between features and instances is carried out based on hierarchical contrastive learning, which contributes to inter‐intra factors potential relationships exploration. Third, a multivariate forecasting model named ResRNN is trained using fused target dataset. Due to its innovation in structure and loss, forecasting accuracy is further improved. Finally, the authors’ method's superiority is confirmed by several groups of comparative experiments and results demonstrate that it outperforms mainstream methods.
A high throughput pseudo‐random number generator driven by four‐dimensional discrete hyper‐chaotic system
Authors: Li Shouliang , Wu Ye , Gao Letian , Li Tangyan , Zhang Qibin , Shen Yulin , Yang Zhen 
Published: September 2023

AbstractPseudo‐random number generators (PRNGs) are the cornerstone of various fields including computer science, cryptography, and scientific simulation. To generate high‐quality and unpredictable pseudo‐random sequences, many works draw attention to the use of chaos theory and dynamical systems. However, most of them focus on continuous or low‐dimensional chaotic systems with strong temporal correlations or insufficient nonlinear dynamics. Thus, in this study, a new PRNG based on a four‐dimensional discrete system is proposed to solve the aforementioned flaws. The PRNG has been implemented on Xilinx Artix‐7 xc7a100tfgg484‐2, which can generate pseudo‐random sequences at a high speed of 12811.53 Mb/s without additional post‐processing. All these sequences have successfully passed the NIST SP800.22 standard test. Both throughput and randomness quality of the proposed PRNG outperform the state‐of‐the‐art.
Multi‐stage stochastic dual dynamic programming to low‐carbon economic dispatch for power systems with flexible carbon capture and storage devices
Authors: Zhang Xiaosheng , Liu Zesan , Ding Tao , Zhang Hongji , Siano Pierluigi , Meng Hongmin , Zhu Chao 
Published: September 2023

AbstractThe carbon capture and storage (CCS) technique gains much attention due to its role in reducing CO2 emissions. By introducing flexible CCS devices into conventional power plants, the low‐carbon economic operation of the power system can be achieved. However, the uncertainty of renewable energy makes it hard to obtain an optimal operation policy. First, the detailed model of CCS consisting of bypass venting stacks, solvent storage tanks, absorber, and stripper is described. Then, a low‐carbon economic dispatch model of the power system with CCS is proposed to minimize the total operation and renewable energy abandonment penalty costs. Next, the problem is reformulated as multi‐stage stochastic programming, and the stochastic dual dynamic programming (SDDP) method is applied to relieve the computation burden. To control the probability of stopping the algorithm prematurely, a new stopping criterion based on a two‐sided hypothesis test is proposed. Finally, the effectiveness of the proposed model and the new stopping criterion is demonstrated by case studies on a practical power system.
Corrected complex torque coefficient method for synchronization stability analysis of grid‐connected VSC
Authors: Zhao Boyuan , Chen Lei , Min Yong , Li Yalou , Xu Shiyun 
Published: September 2023

AbstractSub‐synchronous oscillation of grid‐connected voltage source converter (VSC) dominated by phase locked loop (PLL) is an important stability issue in nowadays power systems. The complex torque coefficient method has been used to investigate the issue because of its advantage of giving insights into source of damping and contributions of different components on damping. However, it is found that the classic complex torque coefficient method is not entirely applicable for stability analysis of VSC because of the proportional term in PLL. This paper proposes a corrected complex torque coefficient method and defines synchronous and damping coefficients. Based on the proposed method, a small‐signal stability criterion is obtained, in which the system stability depends on the sign of corrected damping coefficient. The impacts of different elements on system damping can be quantitatively evaluated through the method. It is drawn that current control loop and line dynamics contribute negative damping, whereas power control loop contributes positive damping. Moreover, the impacts of operating conditions and controller parameters on damping of different elements are analysed. The eigenvalue analyses and electromagnetic transient simulations have verified the theoretical analysis.
Para Powerlifting Performance: A Systematic Review
Authors: Oliveira José Igor V. , de Lucena Erick Guilherme Peixoto , Ferland Pierre-Marc , Oliveira Saulo Fernandes Melo , Uchida Marco Carlos 
Published: September 2023

AbstractThis research aimed to conduct a systematic review of para powerlifting strength
performance. The searches were conducted in three electronic databases: PubMed,
Scopus, and SPORTDiscus. Intervention studies related to para powerlifting
performance were included. The main information was extracted systematically,
based on criteria established by the authors. The data on study design, sample
size, participant’s characteristics (e. g. type of disability,
sex, age, body weight, and height), training experience, assessment tools,
physical performance criteria, and force-related outcomes were extracted and
analyzed. The studies (n=9) describe factors related to biomechanics and
performance. Outcomes revealed that the one-repetition maximum test is used as
load prescription and that para powerlifting should work at high speeds and
higher loads. Regarding technique, grip width with 1.5 biacromial distance
provides a good lift and partial amplitude training as an alternative to
training. There are no differences in total load and movement quality in the
lumbar arched technique compared with the flat technique. As a monitoring
method, repetitions in reserve scale was used for submaximal loads. Finally, our
outcomes and discussion indicated strategies and techniques that can be used by
para powerlifting coaches.
Neuroendokrine Tumoren im Kopf-, Halsbereich
Authors: Duong Dinh Thien An , Braunschweig Till , Ilgner Justus , Westhofen Martin 
Published: September 2023

Zusammenfassung
Hintergrund Neuroendokrine Tumoren (NET) sind benigne oder maligne Neoplasien, die entwicklungsgeschichtlich der Neuralleiste oder paraganglionären Zellen des vegetativen Nervensystems entstammen. Die alte Bezeichnung Karzinoid (karzinomähnlicher Tumor) ist noch sehr verbreitet, jedoch inzwischen obsolet. Lediglich 0,5–2 % aller Neoplasien des Menschen sind neuroendokrine Tumoren, welche überwiegend gastrointestinal oder bronchopulmonal lokalisiert sind. Die Inzidenz beträgt 9.263/100.000. Jedoch ist nur 1 % der Kopf-Hals-Tumore neuroendokriner Genese. Fallzahlstarke Langzeitstudien und Leitlinien zur Diagnose und Therapie im Kopf-Hals-Bereich fehlen. Ziel dieser Arbeit ist der wertende Vergleich bekannter Therapiestrategien und daraus folgender Krankheitsverläufe sowie deren Vergleich mit dem Schrifttum anhand eigener Fälle unterschiedlicher Lokalisation und Ausdehnung.
Patienten und Methoden In unserer Klinik wurden zwischen 2010 und 2017 14 Patienten mit neuroendokrinen Tumoren im Kopf-Hals-Bereich behandelt. Acht Patienten davon wurden primär operativ mit adjuvanter Radiochemotherapie (RCT) versorgt. Sechs Patienten erhielten eine primäre Radiochemotherapie in kurativer Absicht. Ein Patient erhielt aufgrund des Tumorprogresses nach der primären Radiochemotherapie eine weitere Chemotherapie mit palliativer Indikation.
Ergebnisse Die Tumorlokalisationen verteilen sich auf den Larynx (n = 7), die Glandula parotis (n = 2) und auf die Nasenhaupt- und -nebenhöhlen (n=5). Von den 8 operierten Patienten konnte in 6 Fällen eine in-sano-Resektion (R0) erreicht werden. Die im Kollektiv gemessene Gesamtüberlebensrate beträgt im Mittel 19±6 Monate. Von den 14 untersuchten Patienten erlitten 2 Patienten ein Rezidiv, wovon ein Patient nach 7 Monaten verstarb und ein Patient 32 Monate nach der Nachresektion Rezidiv-frei lebt. In zwei Fällen sprach das NET nicht auf die kombinierte RCT an und die Patienten verstarben jeweils nach 6 und 13 Monaten. Die Überlebenszeit ist abhängig vom T-Stadium des NET sowie vom Erreichen einer R0-Resektion. Die R0-Resektion bietet eine höhere Überlebenswahrscheinlichkeit als die primäre RCT.
Schlussfolgerung Patienten mit NET des Kopf-Hals-Bereiches müssen in spezialisierten Zentren interdisziplinär behandelt werden. Zur Erfassung dieser Daten ist eine Tumordatenbank notwendig. Jedoch sind aufgrund der niedrigen Inzidenz keine Studien auf hohem Evidenzniveau zu erwarten. Nach Diagnosestellung sollte ohne zeitliche Verzögerung die im Rahmen einer int. TuKo individuelle auf den Patienten zugeschnittene Therapie erfolgen.
Lebensqualität von Menschen mit einem künstlichen Darmausgang in Deutschland
Authors: Ambe Peter C. , Breuing Jessica , Grohnmann Erich , Engel Nicole , Pieper Dawid , Zirngibl Hubert , Kugler Charlotte 
Published: September 2023

Zusammenfassung
Hintergrund Das Vorhandensein eines Stomas kann einen erheblichen Einfluss auf die Lebensqualität (QoL) haben. Das Ziel dieser Arbeit war die Erfassung der QoL von Menschen mit einem Stoma in Deutschland
Methode Eine offene Internetbefragung mit Hilfe des validierten Gastrointestinalen Quality of Life Index (GIQLI) nach Eypasch wurde durchgeführt. Eingeschlossen wurden vollständig ausgefüllte Fragebögen von Teilnehmenden ≥18 Jahren, deren Stomaoperation ≥3 Monate zurücklag.
Ergebnisse Die 521 eingeschlossenen Teilnehmenden (79,3% weiblich) waren im Median 50 Jahre alt (Spanne: 19–83) und hatten seit 3 Jahren im Median ein Stoma (3 Monate–58 Jahre). Die häufigsten Indikationen für das Stoma waren Morbus Crohn (MC: 36,5%), Darmkrebs (19,8%) und Colitis Ulcerosa (CU: 18,2%). Der QoL-Score betrug durchschnittlich 94,8 ± 24,6, wobei höhere Werte einer höheren Lebensqualität entsprechen, bei einer Spannweite von 0 bis 144 und gesunde Menschen einen Referenzwert von 125,8 haben. Einschränkungen traten besonders bei dem Durchschlafen, der Müdigkeit, dem Kräftezustand, der Ausdauer, der Fitness und dem Sexualleben auf. Unter allen Stomaträgern hatten Teilnehmende mit CU (103,0 ± 24,5), Darmkrebs (99,2 ± 21,7) und MC (95,0 ± 22,8) die höchsten GIQLI-Werte im Durchschnitt.
Diskussion Die Ergebnisse dieser Studie bestätigen, dass die QoL bei Menschen mit einem Stoma schlechter ist verglichen mit Gesunden. Die Untergruppen der Stomaträger mit CU, MC und nach Darmkrebsoperation haben eine höhere QoL als Stomaträger mit anderer Ursache.
Video-Based Assessment of Microsurgical Trainees: An Evaluation of Gender Bias
Authors: Schaefer Eliana J. , Thayer Mary K. , Colon Anthony F. , Sanghavi Kavya K. , Sears Erika D. , Giladi Aviram M. , Katz Ryan D. 
Published: September 2023

Abstract
Background Gender bias in graduate medical evaluations remains a challenging issue. This study evaluates implicit gender bias in video-based evaluations of microsurgical technique, which has not previously been described in the literature.
Methods Two videos were recorded of microsurgical anastomosis; the first was performed by a hand/microsurgery fellow and the second by an expert microsurgeon. A total of 150 surgeons with microsurgical experience were recruited to evaluate the videos; they were told these videos depicted a surgical trainee 1 month into fellowship followed by the same trainee 10 months later. The only variable was the name (“Rachel” or “David”) that each participant was randomly assigned to evaluate. Participants were asked to score each video for quality, technique, efficiency, as well as overall progression and development after the second video compared with the initial video. To focus on bias, these outcome measures were selected to be purposefully subjective and all ratings were based on a subjective 1to 10 scale (10 = excellent).
Results The analysis included 150 participants (75% male). There were no statistically significant differences in scores between the “female” and “male” trainee. The trainees received the same median initial (1-month video) and final (11th-month video) scores for all criteria except initial technique, in which the female trainee received a 7 and the male trainee received an 8. Notably, 11-month scores were consistently the same or lower than 1-month scores for both study groups (p < 0.001). There were also no differences within either study group based on participant sex. Microsurgery practitioners overall rated both groups lower than those who do not currently practice microsurgery.
Conclusion Our study did not identify a gender bias in this evaluation method. Further investigation into how we assess and grade trainees as well as the presence and impact of implicit biases on varying surgical assessment methods is warranted.