bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Efficient β‐Functionalized Oxidomolybdenum(V) Corroles for Catalytic Oxidative Bromination of Phenols at Room Temperature
Authors: Yadav Inderpal , Prakash Ved , Kaswan Ram R. , Maurya Mannar R. , Sankar Muniappan 
Published: September 2023

AbstractTwo new β‐functionalized oxidomolybdenum(V) corroles, oxido[3‐formyl‐5,10,15‐triphenylcorrolato]molybdenum(V) (Mo‐1) and oxido[3‐dicyanovinyl‐5,10,15‐triphenylcorrolato]molybdenum(V) (Mo‐2) were synthesized and characterized by various spectroscopic techniques and electrochemical studies. Mo‐2 manifests splitted B bands due to x and y polarizations and highly red shifted longest B and Q bands due to the electron‐deficient nature of the dicyanovinyl group. EPR data showed that these complexes exhibit an axial compression with dxy1 configuration. DFT studies revealed that HOMO and LUMO orbitals are stabilized in Mo‐2 relative to Mo‐1. Mo‐1 exhibits two successive reversible reductions and two oxidation potentials in cyclic voltammetry. Surprisingly, Mo‐2 exhibits three successive reversible reductions and two oxidations; the one extra reduction could possibly be due to the reduction of the dicyanovinyl moiety. The catalytic activities of Mo‐1 and Mo‐2 for the oxidative bromination of various phenols using H2O2‐KBr‐HClO4 mixture in water have been explored and exhibited excellent activity at a very low catalyst loading of 0.0030 and 0.0028 mol%, respectively. Both synthesized β‐functionalized Mo(V) corroles manifest much higher conversion and TOF (59801–71174 h−1) for oxidative bromination of phenols relative to earlier reported meso‐functionalized Mo(V) corroles (20781–61646 h−1). Hence, Mo‐1 and Mo‐2 mimic vanadium bromoperoxidase (VBPO) and act as functional models for these catalytic applications. These catalysts were reused upto 3 cycles and showed conversion rate upto 82 % indicating their excellent thermal and chemical stabilities.
Rhodium(I) PNN Pincer Complexes with Proton‐responsive Ligands: Synthesis, Characterisation, and Catalytic Dehydrocoupling of Amine Boranes
Authors: Rippke Mirko , Drexler Hans‐Joachim , Beweries Torsten 
Published: September 2023

AbstractCoordination of a pyridine‐pyrazole‐based PNN(H) ligand to RhI produces a family of neutral (1) and cationic (2Cl) RhI complexes. Deprotonation of the parent Rh chloride complex with LiNiPr2 results in formation of a dinuclear LiCl bridged species 3 bearing a pyrazolate fragment. Complexes 1, 2Cl and 3 were tested as precatalyst for the dehydrocoupling of amine boranes. All complexes studied show activity for the formation of cyclic oligomers with N‐methylcyclotriborazane as the main product. Base activation of the neutral Rh chloride complex 1 produces catalyst systems that are significantly more active than the parent system, suggesting that dehydrohalogenation of the Rh chloride precatalyst 1 is one of the key steps for catalyst formation.
Ex‐Situ Generation of Bis(trifluoromethyl)disulfide and Applications to Trifluoromethylthiolation Reactions
Authors: Kolodiazhnaia Julia V. , Gudmundsson Haraldur G. , Pedersen Simon S. , Skrydstrup Troels 
Published: September 2023

AbstractHerein, a convenient and operationally simple protocol for the ex‐situ generation of bis(trifluoromethyl)disulfide from the readily available and commercial Langlois reagent is reported. The one‐step synthesis of the toxic and volatile CF3SSCF3 is performed in a two‐chamber reactor with simple PPh3 and N‐bromosuccinimide as the activator, allowing for the safe handling and tandem utilization in direct trifluoromethylthiolation reactions. The versatility of the ex‐situ generated CF3SSCF3 is demonstrated in known electrophilic, nucleophilic, and a radical trifluoromethylthiolation reactions. Furthermore, the application of the CF3SSCF3 in a copper‐catalyzed cross‐coupling with boronic acids is disclosed, showing good to excellent yields of trifluoromethyl‐substituted aryl products, including pharmaceutically relevant molecules.
The impact of education about historical and current injustices, individual racism and systemic racism on anti‐Indigenous racism
Authors: Efimoff Iloradanon H. , Starzyk Katherine B. 
Published: September 2023

AbstractAnti‐Indigenous racism is a pressing issue in Canada. Education on historical and contemporary Indigenous topics is a common strategy to challenge such racism. Despite the existence of education‐based programmes intended to address anti‐Indigenous racism, there is limited evidence that they are effective. To this end, we report the results of two longitudinal experiments (N1 = 639, N2 = 1099) assessing the effect of education on anti‐Indigenous racism. In both studies, we assessed the impact of five conditions on Indigenous‐related outcomes in samples of non‐Indigenous students. All experimental conditions included information on historical and current injustices toward Indigenous people. In some conditions, we added content on individual racism, systemic racism, or both individual and systemic racism. Results indicated that the experimental conditions improved Indigenous‐related thoughts, feelings, knowledge and behaviours. Further, the conditions containing systemic racism content outperformed the other conditions. These studies showcase the potential of education to reduce anti‐Indigenous prejudice.
Parliamentary oversight of emergency measures and policies: A safeguard of democracy during a crisis?
Authors: Värttö Mikko 
Published: September 2023

AbstractThe article discusses the role of parliamentary oversight of emergency measures and policies in increasing democratic resilience and recovery from the COVID‐19 pandemic. The study on the Finnish Parliament is conducted by analyzing the statements of the Constitutional Law Committee, whose role is to conduct a parliamentary constitutional review of governmental bills. The main focus of the analysis is on the Committee's reviews of the constitutionality of the emergency measures and the procedures of law drafting. The research indicates that the committee considered the restrictions and exceptions of fundamental rights as proportional and necessary to prevent the overburdening of the healthcare system in most cases. However, the justifications for the emergency measures were often lacking, and the parliament's right to receive information was compromised. These deficits undermined the Parliament's capacity to oversee emergency measures and policies. The parliamentary constitutional review during the pandemic could still serve a critical complementary function by protecting fundamental rights and democratic values.
Development of a rapid, sensitive, and selective LC–MS/MS method for quantifying curcumin levels in healthy human urine: Effect of pepper on curcumin bioavailability
Authors: Khajeh pour Sana , Blanton Cynthia , Ghimire Biwash , Aghazadeh‐Habashi Ali 
Published: September 2023

AbstractCurcumin (CCM), a culinary spice, is widely consumed for its health benefits for managing oxidative and inflammatory conditions, metabolic syndrome, arthritis, and hyperlipidemia. However, due to its extensive metabolism, the oral bioavailability of CCM is very low. In this study, we developed a rapid, sensitive, and selective assay to examine the hypothesis that piperine improves CCM bioavailability after piperine co‐ingestion. We developed a selective, sensitive, and robust LC–MS/MS method to quantify CCM in human urine. The method was linear over a concentration range 0.625–40 ng/mL with LLOQ and LLOD of 0.625 ng/mL and 0.312 ng/mL, respectively. Healthy volunteers have consumed test meals of CCM as turmeric powder with and without black pepper with 1 week wash out. Urine samples were collected for 24 hours and analyzed for CCM excretion. Black pepper increased CCM half‐life from 2.2 ± 0.79 h (CCM alone) to 4.5 ± 0.80 h (CCM + pepper). The CCM 24‐h urinary excreted amount was higher in individuals consuming CCM + pepper (218.14 ± 94.98 μg) than those who received CCM only (49.45 ± 12.94 μg). This preliminary study indicates that piperine significantly increased CCM oral absorption, reduced systemic clearance, and improved bioavailability.
A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
Authors: Golmohammadi Maryam , Zamanian Mohammad Yasin , Jalal Sahbanathul Missiriya , Noraldeen Sara Abdalrazzaq M. , Ramírez‐Coronel Andrés Alexis , Oudaha Khulood H. , Obaid Rasha Fadhel , Almulla Abbas F. , Bazmandegan Gholamreza , Kamiab Zahra 
Published: September 2023

AbstractGlobally, breast cancer (BC) is the leading cause of cancer‐related deaths in women. Hence, developing a therapeutic plan to overcome the disease is crucial. Numerous factors such as endogenous hormones and environmental factors may play a role in the pathophysiology of BC. Regarding the multi‐modality treatment of BC, natural compounds like ellagic acid (EA) received has received increased interest in antitumor efficacy with lower adverse effects. Based on the results of this comprehensive review, EA has multiple effects on BC cells including (1) suppresses the growth of BC cells by arresting the cell cycle in the G0/G1 phase, (2) suppresses migration, invasion, and metastatic, (3) stimulates apoptosis in MCF‐7 cells via TGF‐β/Smad3 signaling axis, (4) inhibits CDK6 that is important in cell cycle regulation, (5) binds to ACTN4 and induces its degradation via the ubiquitin‐proteasome pathway, inducing decreased cell motility and invasion in BC cells, (6) inhibits the PI3K/AKT pathway, and (7) inhibits angiogenesis‐associated activities including proliferation (reduces VEGFR‐2 tyrosine kinase activity). In conclusion, EA exhibits anticancer activity through various molecular mechanisms that influence key cellular processes like apoptosis, cell cycle, angiogenesis, and metastasis in BC. However, further researches are essential to fully elucidate its molecular targets and implications for clinical applications.
Novel NCOA2/3‐rearranged low‐grade fibroblastic spindle cell tumors: A report of five cases
Authors: Bakhshwin Ahmed , Armstrong Susan M. , Duckworth Lauren A. , Stoehr Robert , Konishi Eiichi , Rubin Brian P. , Fritchie Karen J. , Dickson Brendan C. , Agaimy Abbas , Dermawan Josephine K. 
Published: September 2023

AbstractSpindle cell mesenchymal neoplasms are a diverse and often challenging diagnostic group. While morphological impression is sufficient for some diagnoses, increasingly immunohistochemical and even molecular data is required to render an accurate diagnosis, which can lead to the characterization of new entities. We describe five cases of novel mesenchymal neoplasms with rearrangements in the NCOA2 and NCOA3 genes partnered with either CTCF or CRTC1. Three tumors occurred in the head and neck (palate, auditory canal), while the other two were in visceral organs (lung, urinary bladder). All cases occurred in adults (range 33–86) with a median age of 42 and fairly even sex distribution = (male‐to‐female = 3:2). Morphologically, they had similar features consisting of monotonous, bland spindle to ovoid cells with fascicular and reticular arrangements in a myxohyaline to collagenous stroma. However, immunophenotypically they had essentially a null phenotype, with only two tumors staining partially for CD34 and smooth muscle actin. Targeted RNA sequencing detected in‐frame CTCF::NCOA2 (one case), CRTC1::NCOA2 (two cases), and CTCF::NCOA3 (two cases) fusions. Treatment was surgical resection in all cases. Local recurrence and/or distant metastases were not observed in any case (median follow‐up, 7.5 months; range, 2–19 months). Given their morphologic, immunohistochemical, and molecular similarities, we believe that these cases may represent an emerging family of low‐grade NCOA2/3‐rearranged fibroblastic spindle cell neoplasms.
Neonatal PURA syndrome mimicking cervical spinal cord injury after a cesarean section for a breech presentation: A case report
Authors: Zhang Duoduo , Gao Jinsong 
Published: September 2023

SynopsisThe neonatal PURA syndrome manifesting as hypotonia, dyspnea, and feeding difficulties mimic the birth trauma of the spinal cord but can only be diagnosed with sequencing.
Impact of educational workshops to increase awareness of pelvic floor dysfunction and integrate preventive lifestyle habits
Authors: Pizzoferrato Anne‐Cécile , Deparis Julia , Fritel Xavier , Rousseau Marion , Blanchard Véronique 
Published: September 2023

AbstractObjectivesOur objectives were to evaluate the impact of group pelvic floor education workshops on participants' knowledge, their satisfaction, and the modification of their urinary and digestive behaviors, and to compare health care providers' (HCP) knowledge with that of the general population.MethodsFor this prospective observational study, group pelvic floor education workshops were proposed between May 2021 and June 2022 in a web‐conference format. Each workshop covered pelvic floor anatomy and physiology, urinary and digestive physiology as well as risk factors of PFD and preventive measures. At the start and the end of the workshops, participants completed a questionnaire on their knowledge and their beliefs about the pelvic floor. Questions about their satisfaction were asked at the end of the workshops. A 2‐month questionnaire assessed changes in urinary and digestive habits and whether participants had talked about the workshop around them.ResultsA total of 856, with an average age 40.1 years, participated and completed the questionnaires before and after the workshops; 694 responded at 2 months. The education workshops significantly improved knowledge about the pelvic floor in the “HCP” and “non‐HCP” groups. At 2 months, 591 participants (85.2%) 85.2% had talked about the workshop content; 557 (80.3%) reported having changed, or planned to change, their urinary behaviors and 495 (71.3%) their defecatory behaviors.ConclusionsPelvic floor education workshops can increase level of knowledge and thus limit risky behaviors for the pelvic floor. The high rate of participation and the satisfaction of the participants shows the interest for the theme.
LH on GnRH‐ant day to basal LH affects the IVF/ICSI outcome of PCOS women undergoing GnRH‐antagonist protocol
Authors: Wei Yi , Luan Ting , Shen Jingjing , Zhang Juanjuan , Zhang Juan , Su Yan , Ling Xiufeng , Li Xin , Zhao Chun 
Published: September 2023

AbstractObjectiveThe aim of this study was to investigate the influence of ratio of serum luteinizing hormone (LH) on gonadotropin‐releasing hormone antagonist (GnRH‐ant) day to basal LH (hLH/bLH) on in‐vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) outcome in polycystic ovary syndrome (PCOS) women who received GnRH‐ant protocol for controlled ovarian hyperstimulation (COH).MethodsThis retrospective study was conducted in women with PCOS (n = 1116) who underwent the GnRH‐ant protocol for COH between 2015 and 2022 and were stratified as group A (hLH/bLH < 1, n = 489) and group B (hLH/bLH ≥ 1, n = 627) according to the variation of serum LH. The outcomes of COH and the first frozen embryo transfer (FET) cycle were compared between group A, B and the linear relationship between hLH/bLH ratio and IVF/ICSI outcomes were studied by multivariate linear regression analysis and restricted cubic spline (RCS) models.ResultsThere were significant differences in baseline characteristics and outcomes between group A and B. Group A had higher levels of bLH, AMH, estradiol (E2) on GnRH‐ant start day and lower levels of LH on GnRH‐ant start day. Group B has better ovulation induction outcomes: more retrieved oocytes, normally fertilized oocytes (2PN), cleavage embryos, available embryos and high‐quality blastocysts. Multivariate linear regression analysis found no statistically significant connection between hLH/bLH and clinical outcomes. RCS models showed hLH/bLH had nonlinear association with outcomes, including number of oocytes retrieved, 2PN, available embryos, incidence of OHSS, chemical pregnancy, clinical pregnancy, abortion and live birth.ConclusionshLH/bLH ratio could be a more forward‐looking indicator of clinical outcome in women with PCOS undergoing GnRH‐ant protocols than LH on trigger day and the ratio of LH level on trigger day to basal LH. hLH/bLH = 1 may be the best condition for higher live birth rate and lower OHSS rate.
The hyper‐regulation of abortion care in Italy
Authors: Caruso Elena 
Published: September 2023

AbstractThis paper argues that the current abortion regulation by Law 194/1978 is an inadequate basis for the provision of good quality abortion care and must be reformed. First, the paper explains why Law 194/1978 creates a hyper‐regulatory regime that is inconsistent with the best clinical evidence and practices in the field as well as relevant international human rights law, as outlined in the World Health Organization's (WHO) 2022 Abortion Care Guideline. Second, it highlights gaps between what the law says and what happens in practice, pointing out how the everyday life of Law 194/1978, especially in the practices of gynecologists, is far removed from international standards of quality abortion care and has yet to comply with international human rights law. Third, it sets out some alternative routes to abortion access “outside” Law 194/1978. Finally, it concludes with some suggestions for a change in the practice of gynecology and a call for the reform of Law 194/1978, in favor of a bodily autonomy model of regulation grounded on decriminalization, demedicalization, dehospitalization, and self‐management to ensure compliance with the WHO standards and international human rights law.
Heparin–collagen I bilayers stimulateFAK/ERK½ signaling via α2β1 integrin to support the growth and anti‐inflammatory potency of mesenchymal stromal cells
Authors: Cifuentes Said J. , Domenech Maribella 
Published: September 2023

AbstractUnderstanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high‐quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to investigate the role of integrin‐HEP interactions in the advantages of MSC culture. The layer‐by‐layer approach (LbL) was used to create HEP/COL bilayers, which were made up of stacks of 8 and 9 layers that combined HEP and COL in an alternate arrangement. Surface spectroscopic investigations and laser scanning microscopy evaluations verified the biochemical fingerprint of each component and a total stacked bilayer thickness of roughly 150 nm. Cell growth and apoptosis in response to IC50and IC75levels of BTT‐3033 and Cilengitide, α2β1 and αvβ3 integrin inhibitors respectively, were evaluated on HEP/COL coated surfaces using two bone marrow‐derived MSC donors. While integrin activity did not affect cell growth rates, it significantly affected cell adhesion and apoptosis on HEP/COL surfaces. HEP‐ending HEP/COL surfaces significantly increased FAK‐ERK½ phosphorylation and endogenous cell COL deposition compared to COL, COL‐ending HEP/COL and uncoated surfaces. BTT‐3033 but not Cilengitide treatment markedly affected FAK‐ERK½ activity levels on HEP‐ending HEP/COL surfaces supporting a major role for α2β1 activity. BTT‐3033 treatment on HEP‐ending bilayers reduced MSC‐mediated macrophage inhibitory activity and altered the cytokine profile of co‐cultures. Overall, this study supports a novel role for HEP in regulating the survival and potency of MSCs via enhancing the α2β1‐FAK‐ERK½ signaling mechanism.
Chitosan‐sodium alginate‐polyethylene glycol‐Ally isothiocyante nanocomposites ameliorates isoproterenol‐induced myocardial infarction in rats
Authors: Jiang Lei , Gao Tingchao , Liu Miao , Li Fangxu 
Published: September 2023

AbstractMyocardial infarction (MI) is a common type of ischemic heart disease that affects millions of people worldwide. In recent times, nanotechnology has become a very promising field with immense applications. The current exploration was conducted to synthesize the chitosan‐sodium alginate‐polyethylene glycol‐Ally isothiocyanate nanocomposites (CSP‐AIso‐NCs) and evaluate their beneficial roles against the isoproterenol (ISO)‐induced MI in rats. The CSP‐AIso‐NCs were prepared and characterized by several characterization techniques. The MI was initiated in the rats by the administration of 85 mg/kg of ISO for 2 days and treated with 10 and 20 mg/kg of CSP‐AIso‐NCs for 1 month. The changes in heart weight and bodyweight were measured. The cardiac function markers were assessed with echocardiography. The lipid profiles, Na+, K+, and Ca2+ ions, cardiac biomarkers, antioxidant parameters, and inflammatory cytokines were assessed using corresponding assay kits. The histopathological study was done on the heart tissues. The UV spectral analysis revealed the maximum peak at 208 nm, which confirms the formation of CSP‐AIso‐NCs. The FT‐IR analysis revealed the occurrence of different functional groups, and the crystallinity of the CSP‐AIso‐NCs was proved by the XRD analysis. DLS analysis indicated the size of the CSP‐AIso‐NCs at 146.50 nm. The CSP‐AIso‐NCs treatment increased the bodyweight and decreased the HW/BW ratio in the MI rats. The status of lipids was reduced, and HDL was elevated in the CSP‐AIso‐NCs administered to MI rats. CSP‐AIso‐NCs decreased the LVEDs, LVEDd, and NT‐proBNP and increased the LVEF level. The oxidative stress markers were decreased, and the antioxidants were increased by the CSP‐AIso‐NCs treatment in the MI rats. The Na+ and Ca+ ions were reduced, and the K+ ions were increased by the CSP‐AIso‐NCs. The interleukin‐1β and tumor necrosis factor‐α were also depleted, and Nrf‐2 was improved in the CSP‐AIso‐NCs administered to MI rats. The histological study revealed the ameliorative effects of CSP‐AIso‐NCs. Overall, our outcomes revealed that the CSP‐AIso‐NCs are effective against the ISO‐induced MI rats. Hence, it could be a hopeful therapeutic nanomedicine for MI treatment.