bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demand Volatility and Firm Export Margins: Evidence from Egypt
Authors: Kamal Yasmine 
Published: April 2023

The study explains the export behavior of Egyptian firms under demand volatility in destination countries using detailed customs data and high-dimensional fixed effects. It finds that demand volatility negatively affects both the intensive and extensive export margins. The effects are particularly evident for large firms which reduce their export sales — especially over time — to more volatile destinations/products, are more likely to exit from exporting more volatile products and are less (more) likely to enter (exit) more volatile destinations. These findings confirm recent literature that emphasizes the greater elasticity of large firms to foreign demand shocks. They are also in line with risk aversion models in which the average risk premium increases with firm size. Given the disproportionate adverse impacts on large exporters, we find that higher demand volatility leads to lower aggregate exports, especially to geographically close and low trade costs countries. Accordingly, uncertainty in demand lessens the positive effect of lower trade barriers on exports.
Notas sobre a história da igreja Matriz de Santo Antônio, no distrito de Glaura, em Ouro Preto
Authors: Pedrosa Aziz José de Oliveira 
Published: April 2023

A igreja Matriz de Santo Antônio, localizada no distrito de Glaura, em Ouro Preto, foi reconstruída por volta de 1750 em substituição à antiga capela, erguida na década de 1720, que se encontrava em ruína. A história desse templo abrange notas importantes e necessárias para a compreensão do processo de produção da arte e da arquitetura setecentista em Minas Gerais. Este artigo objetiva relacionar informações sobre a história da referida igreja, obtidas a partir do exame de documentação primária, temática escassamente investigada na atualidade.
Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress
Authors: Kroll Rachel G. , Powell Corey , Chen Jun , Snider Natasha T. , St. Hilaire Cynthia , Reddy Akshay , Kim Judy , Pinsky David J. , Murthy Venkatesh L. , Sutton Nadia R. 
Published: April 2023

Background
Ectonucleotidases maintain vascular homeostasis by metabolizing extracellular nucleotides, modulating inflammation and thrombosis, and potentially, myocardial flow through adenosine generation. Evidence implicates dysfunction or deficiency of ectonucleotidases CD39 or CD73 in human disease; the utility of measuring levels of circulating ectonucleotidases as plasma biomarkers of coronary artery dysfunction or disease has not been previously reported.

Methods and Results

A total of 529 individuals undergoing clinically indicated positron emission tomography stress testing between 2015 and 2019 were enrolled in this single‐center retrospective analysis. Baseline demographics, clinical data, nuclear stress test, and coronary artery calcium score variables were collected, as well as a blood sample. CD39 and CD73 levels were assessed as binary (detectable, undetectable) or continuous variables using ELISAs. Plasma CD39 was detectable in 24% of White and 8% of Black study participants (
P
=0.02). Of the clinical history variables examined, ectonucleotidase levels were most strongly associated with underlying liver disease and not other traditional coronary artery disease risk factors. Intriguingly, detection of circulating ectonucleotidase was inversely associated with stress myocardial blood flow (2.3±0.8 mL/min per g versus 2.7 mL/min per g±1.1 for detectable versus undetectable CD39 levels,
P
<0.001) and global myocardial flow reserve (Pearson correlation between myocardial flow reserve and log(CD73) −0.19,
P
<0.001). A subanalysis showed these differences held true independent of liver disease.

Conclusions
Vasodilatory adenosine is the expected product of local ectonucleotidase activity, yet these data support an inverse relationship between plasma ectonucleotidases, stress myocardial blood flow (CD39), and myocardial flow reserve (CD73). These findings support the conclusion that plasma levels of ectonucleotidases, which may be shed from the endothelial surface, contribute to reduced stress myocardial blood flow and myocardial flow reserve.
Incremental Value of Exercise ECG to Myocardial Perfusion Single‐Photon Emission Computed Tomography for Prediction of Cardiac Events
Authors: Kraen Morten , Akil Shahnaz , Hedén Bo , Berg Jonathan , Ostenfeld Ellen , Carlsson Marcus , Arheden Håkan , Engblom Henrik 
Published: April 2023

Background
Both myocardial perfusion single‐photon emission computed tomography (MPS) and exercise ECG (Ex‐ECG) carry prognostic information in patients with stable chest pain. However, it is not fully understood if combining the findings of MPS and Ex‐ECG improves risk prediction. Current guidelines no longer recommend Ex‐ECG for diagnostic evaluation of chronic coronary syndrome, but Ex‐ECG could still be of incremental prognostic importance.

Methods and Results

This study comprised 908 consecutive patients (age 63.3±9.4 years, 49% male) who performed MPS with Ex‐ECG. Subjects were followed for 5 years. The end point was a composite of cardiovascular death, acute myocardial infarction, unstable angina, and unplanned percutaneous coronary intervention. National registry data and medical charts were used for end point allocation. Combining the findings of MPS and Ex‐ECG resulted in concordant evidence of ischemia in 72 patients or absence of ischemia in 634 patients. Discordant results were found in 202 patients (MPS−/Ex‐ECG+, n=126 and MPS+/Ex‐ECG−, n=76). During follow‐up, 95 events occurred. Annualized event rates significantly increased across groups (MPS−/Ex‐ECG− =1.3%, MPS−/Ex‐ECG+ =3.0%, MPS+/Ex‐ECG− =5.1% and MPS+/Ex‐ECG+ =8.0%). In multivariable analyses MPS was the strongest predictor regardless of Ex‐ECG findings (MPS+/Ex‐ECG−, hazard ratio [HR], 3.0,
P
=0.001 or MPS+/Ex‐ECG+, HR,4.0,
P
<0.001). However, an abnormal Ex‐ECG almost doubled the risk in subjects with normal MPS (MPS−/Ex‐ECG+, HR, 1.9,
P
=0.04).

Conclusions
In patients with chronic coronary syndrome, combining the results from MPS and Ex‐ECG led to improved risk prediction. Even though MPS is the stronger predictor, there is an incremental value of adding data from Ex‐ECG to MPS, especially in patients with normal MPS.
Aortic Dissection During Pregnancy and Puerperium: Contemporary Incidence and Outcomes in the United States
Authors: Wang Yunda , Yin Kanhua , Datar Yesh , Mohnot Joy , Nodoushani Ariana Y. , Zhan Yong , Karlson Karl J. , Edwards Niloo M. , Reardon Michael J. , Dobrilovic Nikola 
Published: April 2023

Background
Aortic dissection (AD) during pregnancy and puerperium is a rare catastrophe with devastating consequences for both parent and fetus. Population‐level incidence trends and outcomes remain relatively undetermined.

Methods and Results

We queried a US population‐based health care database, the National Inpatient Sample, and identified all patients with a pregnancy‐related AD hospitalization from 2002 to 2017. In total, 472 pregnancy‐related AD hospitalizations (mean age, 30.9±0.6 years) were identified from 68 514 000 pregnancy‐related hospitalizations (0.69 per 100 000 pregnancy‐related hospitalizations), with 107 (22.7%) being type A and 365 (77.3%) being type B. The incidence of AD appeared to increase over the 16‐year study period but was not statistically significant (
P
for trend >0.05). Marfan syndrome, primary hypertension, and preeclampsia/eclampsia were found in 21.9%, 14.4%, and 11.5%, respectively. On multivariable logistic regression analysis, Marfan syndrome was associated with the highest risk of developing AD during pregnancy and puerperium (adjusted odds ratio, 3469.36 [95% CI, 1767.84–6831.75];
P
<0.001). The in‐hospital mortalities of AD, type A AD, and type B AD were 7.3%, 4.3%, and 8.1%, respectively. Length of hospital stay for the AD, type A AD, and type B AD groups were 7.7±0.8, 10.4±1.9, and 6.9±0.9 days, respectively.

Conclusions
We quantified population‐level incidence and in‐hospital mortality in the United States and observed an increase in the incidence of pregnancy‐related AD. In contrast, its in‐hospital mortality appears lower than that of non–pregnancy‐related AD.
Repeat Mitral Transcatheter Edge‐to‐Edge Repair for Recurrent Significant Mitral Regurgitation
Authors: Shechter Alon , Lee Mirae , Kaewkes Danon , Koren Ofir , Skaf Sabah , Chakravarty Tarun , Koseki Keita , Patel Vivek , Makkar Raj R. , Siegel Robert J. 
Published: April 2023

BackgroundThere are limited data on repeat mitral transcatheter edge‐to‐edge repair for recurrent significant mitral regurgitation (MR).Methods and ResultsWe conducted a single‐center, retrospective analysis of consecutive patients referred to a second mitral transcatheter edge‐to‐edge repair after a technically successful first procedure. Clinical, laboratory, and echocardiographic measures were assessed up to 1 year after the intervention. The composite of all‐cause death or heart failure (HF) hospitalizations constituted the primary outcome. A total of 52 patients (median age, 81 [interquartile range, 76–87] years, 29 [55.8%] men, 26 [50.0%] with functional MR) met the inclusion criteria. MR recurrences were mostly related to progression of the underlying cardiac pathology. All procedures were technically successful. At 1 year, most patients with available records (n=24; 96.0%) experienced improvement in MR severity or New York Heart Association functional class that was statistically significant but numerically modest. Fourteen (26.9%) patients died or were hospitalized due to HF. These were higher‐risk cases with predominantly functional MR who mostly underwent an urgent procedure and exhibited more severe HF indices before the intervention, as well as an attenuated 1‐month clinical and echocardiographic response. Overall, 1‐year course was comparable to that experienced by patients who underwent only a first transcatheter edge‐to‐edge repair at our institution (n=902). Tricuspid regurgitation of greater than moderate grade was the only baseline parameter to independently predict the primary outcome.ConclusionsRepeat mitral transcatheter edge‐to‐edge repair is feasible, safe, and clinically effective, especially in non‐functional MR patients without concomitant significant tricuspid regurgitation.
An Army Like Goats: A Semantic and Zoological Reconsideration of 1 Kings 20:27
Authors: Schreiner David B. , Greenwood Kyle R. 
Published: April 2023

Abstract
This article examines the tendencies surrounding 1 Kgs 20:27 and ultimately proposes an alternative translation for and understanding of the phrase כִּשְׁנֵי חֲשִׂפֵי עִזִּים. We open with a survey of major English translations and commentary by salient interpreters to emphasize tendencies associated with the passage. We then examine the grammar and semantics of the passage in conjunction with ancient translations in order to highlight a disconnect between the translations and the Hebrew text. We then evaluate a proposal from Amitai Baruchi-Unna and argue that while he properly considers behavioral traits of the genus Capra to explain the imagery of 1 Kgs 20:27, his proposal is ultimately deficient. In response, we consider the phrase כִּשְׁנֵי חֲשִׂפֵי עִזִּים in conjunction with specific behaviors and physiological characteristics of certain species within the genus Capra. We propose that the description of the Israelite army may recall specific behaviors and characteristics of rutting male goats.
Two new species of Onycocaris (Decapoda, Palaemonidae) from the central Pacific
Authors: De Grave Sammy , Park Jin-Ho , Anker Arthur 
Published: April 2023

Abstract
Two new species of the genus Onycocaris are described, based on single specimens from Fiji and Moorea respectively. Onycocaris iti sp. nov. is closely related to the relatively widespread species, O. seychellensis Bruce, 1971; whilst O. brucei sp. nov. is a pseudo-cryptic species allied to O. quadratophthalma (Balss, 1921).
Space Diplomacy and the ‘Overview Effect’
Authors: White Frank 
Published: April 2023

Summary
Astronauts looking at Earth from orbital or lunar missions often say they cannot see borders and boundaries that mean so much to surface dwellers, an essential feature of the ‘Overview Effect’, a term the author coined to describe the identity shift that takes place for many space travellers. What does this portend for the future? Should we simply forget borders, since they are merely products of our minds? What about diplomacy, which is all about borders and boundaries insofar as it is about inter-national relations. Will the art of diplomacy change as nation-states send more residents to explore the rest of the solar ecosystem? This question seems more relevant than ever, while war rages, largely over borders and boundaries, in the heart of Europe. We consider how the ‘Overview Effect’ influences communication, persuasion, and bargaining among state and non-state actors active in determining the shape of our future spacefaring civilisation.
Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial
Authors: Jiang Wenyu , Wang Xing , Xu Hong , Liu Menghan , Xie Jinwei , Huang Qiang , Zhou Ronghua , Zhou Zongke , Pei Fuxing 
Published: April 2023

Abstract
Background
Multiple doses of dexamethasone and tranexamic acid can inhibit postoperative inflammation and reduce fibrinolysis and perioperative blood loss in total knee arthroplasty. In this single-center, double-blind, randomized clinical trial, the aim was to investigate whether applying a tourniquet to patients on dexamethasone and tranexamic acid could further reduce perioperative blood loss.

Materials and methods
Patients who underwent cemented total knee arthroplasty at our hospital were randomized to receive a tourniquet (n = 71) or not (n = 70) during the procedure. All patients received multiple doses of dexamethasone and tranexamic acid perioperatively. The primary outcome was perioperative blood loss, while secondary outcomes were surgery duration, postoperative laboratory indices of inflammation and fibrinolysis, range of knee motion, VAS pain score, knee circumference, knee swelling rate, homologous transfusion, albumin use, and complications.

Results
Using a tourniquet was associated with significantly lower intraoperative blood loss (P < 0.001) and total blood loss (P = 0.007) as well as significantly shorter surgery duration (P < 0.001). In contrast, the tourniquet did not significantly affect hidden blood loss, postoperative inflammation or fibrinolysis, range of knee motion, VAS pain score, knee circumference, knee swelling rate, homologous transfusion, albumin use, or complications.

Conclusions
The results of this randomized clinical trial demonstrate that applying a tourniquet during cemented total knee arthroplasty to patients receiving multiple doses of dexamethasone and tranexamic acid can further reduce perioperative blood loss without increasing the risk of inflammation, fibrinolysis, or other complications. Thus, it is advised to use tourniquets combined with dexamethasone and tranexamic acid to reduce perioperative blood loss and avoid tourniquet-related adverse events.
Level of evidence: Therapeutic Level I.
Trial registration Chinese Clinical Trail Registry, ChiCTR2200060567. Registered 5 June 2022—retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=171291.
Genetic diversity, population structure, and genome-wide association study for the flowering trait in a diverse panel of 428 moth bean (Vigna aconitifolia) accessions using genotyping by sequencing
Authors: Yadav Arvind Kumar , Singh Chandan Kumar , Kalia Rajwant K. , Mittal Shikha , Wankhede Dhammaprakash P. , Kakani Rajesh K. , Ujjainwal Shraddha , Aakash  , Saroha Ankit , Nathawat N. S. , Rani Reena , Panchariya Pooja , Choudhary Manoj , Solanki Kantilal , Chaturvedi K. K. , Archak Sunil , Singh Kuldeep , Singh Gyanendra Pratap , Singh Amit Kumar 
Published: April 2023

Abstract
Background
Moth bean (Vigna aconitifolia) is an underutilized, protein-rich legume that is grown in arid and semi-arid areas of south Asia and is highly resistant to abiotic stresses such as heat and drought. Despite its economic importance, the crop remains unexplored at the genomic level for genetic diversity and trait mapping studies. To date, there is no report of SNP marker discovery and association mapping of any trait in this crop. Therefore, this study aimed to dissect the genetic diversity, population structure and marker-trait association for the flowering trait in a diversity panel of 428 moth bean accessions using genotyping by sequencing (GBS) approach.

Results
A total of 9078 high-quality single nucleotide polymorphisms (SNPs) were discovered by genotyping of 428 moth bean accessions. Model-based structure analysis and PCA grouped the moth bean accessions into two subpopulations. Cluster analysis revealed accessions belonging to the Northwestern region of India had higher variability than accessions from the other regions suggesting that this region represents its center of diversity. AMOVA revealed more variations within individuals (74%) and among the individuals (24%) than among the populations (2%). Marker-trait association analysis using seven multi-locus models including mrMLM, FASTmrEMMA FASTmrEMMA, ISIS EM-BLASSO, MLMM, BLINK and FarmCPU revealed 29 potential genomic regions for the trait days to 50% flowering, which were consistently detected in three or more models. Analysis of the allelic effect of the major genomic regions explaining phenotypic variance of more than 10% and those detected in at least 2 environments showed 4 genomic regions with significant phenotypic effect on this trait. Further, we also analyzed genetic relationships among the Vigna species using SNP markers. The genomic localization of moth bean SNPs on genomes of closely related Vigna species demonstrated that maximum numbers of SNPs were getting localized on Vigna mungo. This suggested that the moth bean is most closely related to V. mungo.

Conclusion
Our study shows that the north-western regions of India represent the center of diversity of the moth bean. Further, the study revealed flowering-related genomic regions/candidate genes which can be potentially exploited in breeding programs to develop early-maturity moth bean varieties.
High and low value care recommended and undertaken prior to knee or hip arthroplasty: a survey study
Authors: Mills Kathryn , Brewster Anne-Marie , Hackett Danella , Cheung Chris , Solomon Michael , Naylor Justine 
Published: April 2023

Abstract
Introduction
National and international clinical practice guidelines have stratified the value of osteoarthritis (OA) interventions. Interventions with strong evidence supporting effectiveness and benefit are ‘high value care’. Appointment attendance, audits and practitioner surveys are widely used to determine frequency of recommendations and adherence to high value care. Greater patient reported data is needed in this evidence base.

Objective
To describe the frequency of high and low value care being recommended and undertaken by individuals awaiting OA-related lower limb arthroplasty. To examine sociodemographic or disease-related variables associated with being recommended different levels of care.

Methods
A cross-sectional survey of 339 individuals was conducted in metropolitan and regional hospitals and surgeon consultation rooms across New South Wales (NSW), Australia. Individuals attending pre-arthroplasty clinics/appointments for primary arthroplasty of the hip and/or knee were invited to participate. Respondents were asked what intervention(s) they were recommended by healthcare practitioners, or other sources of information, and what they had undertaken within two years prior to hip or knee arthroplasty. Interventions were classified as core, recommended, and low value care aligned with the Osteoarthritis Research Society International (OARSI) guidelines. We considered core and recommended interventions high value. The proportion of recommended and undertaken interventions were calculated. We used backwards stepwise multivariate multinomial regression to address aim three.

Results
Simple analgesics were most frequently recommended (68% [95% CI 62.9 to 73.1]). 24.8% [20.2 to 29.7] of respondents were recommended high value care only. 75.2% [70.2 to 79.7] of respondents were recommended at least one low value intervention. More than 75% of recommended interventions were undertaken. Respondents awaiting hip arthroplasty, living outside a major city and without private health insurance had greater odds of recommended rather than core interventions being advised.

Conclusion
While high value interventions are being recommended to individuals living with OA, in most cases they are combined with recommendations for low value care. This is concerning given the high rates of uptake for recommended interventions. Based on patient reported data, disease-related and sociodemographic variables influence the level of care recommended.
Efficacy of ultrasound guided caudal epidural steroid injection with or without ozone in patients with lumbosacral canal stenosis; a randomized clinical controlled trial
Authors: Rayegani Seyed Mansoor , Soltani Vahid , Cheraghi Mohsen , Omid Zohor Mohammad Reza , Babaei-Ghazani Arash , Raeissadat Seyed Ahmad 
Published: April 2023

Abstract
Background
Lumbosacral canal stenosis is known as the most common cause of back surgery with several complications. Selecting a minimally invasive treatment with high efficacy in such patients is necessary. This study was designed to evaluate the effectiveness of ozone therapy in combination with caudal epidural steroid in patients with lumbar spinal stenosis.

Methods
A double-blind randomized clinical trial was conducted on 50 patients with lumbar spinal stenosis allocated into two study groups. Under ultrasound guidance, the first group received 80 mg of triamcinolone hexavalent with 4 mL of Marcaine 0.5% and 6 mL of distilled water to the caudal epidural space. The second group received an injection similar to the first group, combined with 10 mL of ozone (O2-O3) gas at a concentration of 10 µg/cc. The patients were followed at baseline, one, and six months after injection with clinical outcomes measures using Visual Analog Scale (VAS), Walking Distance (WD) and Oswestry Disability Index (ODI).

Results
The mean age of subjects, 30 males (60%) and 20 females (40%), was reported as 64.51 ± 7.19 years old. Reduction of pain intensity based on VAS score was statistically significant in both groups at follow-up periods (P < 0.001). The VAS changes in the first month and sixth months showed no significant difference between the two groups (P = 0.28 and P = 0.33, respectively). The improvement in disability index (ODI) in both types of treatment during follow-up was significant (P < 0.0001), and there was no difference between the two treatment groups in one month and six months (P = 0.48 and P = 0.88, respectively). As for walking distance, the improvement process with both types of treatment during follow-up periods was significant (P < 0.001). However, after one and six months of treatment, the rate of improvement in patients’ walking distance in the caudal epidural steroid injection plus ozone group was significantly higher than in the epidural steroid group (p = 0.026 and p = 0.017, respectively).

Conclusions
In this study, the results of VAS and ODI outcomes showed that caudal epidural steroid injection combined with ozone has no advantage over caudal epidural steroid injection alone. Interestingly, our results demonstrated that the group receiving caudal epidural steroid injection plus ozone scored significantly higher on the walking distance index than the group receiving caudal epidural steroid alone.

Trial Registration
IRCT IRCT20090704002117N2 (registration date: 07/08/2019).