bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control
Authors: Zhang Kaiwen , Xian Yiwen , Li Ming , Pan Zheng , Zhu Ziran , Yang Yu , Wang Hufei , Zhang Licheng , Zhang Chong , Wu Decheng 
Published: August 2023

AbstractHemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, and do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable and adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH2), and tetra‐armed poly(ethylene glycol) succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, the macroporous CM can rapidly absorb the interfacial liquids, and meanwhile, the hydrated GAP turns into hydrogel (crosslinking between Tetra‐PEG‐SS and CM/Tetra‐PEG‐NH2) with stable and robust adhesion to the wet tissue though covalent bonding. The in vitro and in vivo results suggest that the GAP with optimized formulation exhibits strong tissue adhesive, high burst pressure, and enhanced blood clotting ability, as well as excellent biocompatibility and on‐demand removal properties. A significantly improved hemostatic efficacy is demonstrated in the rat liver, spleen, and femoral artery injury models compared to that of the CM, commercial fibrin glue, and Yunnan Baiyao (YB). The GAP can also halt the severe bleeding from pig visceral organs. Overall, the proposed GAP has many advantages including good biocompatibility, rapid and effective hemostasis, low cost, and ease of use, making it as a promising hemostat for lethal non‐compressible hemorrhage control.
High‐Efficiency Thermoelectric Module Based on High‐Performance Bi0.42Sb1.58Te3 Materials
Authors: Wu Gang , Zhang Qiang , Fu Yuntian , Tan Xiaojian , Noudem Jacques G. , Zhang Zongwei , Cui Chen , Sun Peng , Hu Haoyang , Wu Jiehua , Liu Guo‐Qiang , Jiang Jun 
Published: August 2023

AbstractBismuth‐telluride‐based alloy is the sole thermoelectric candidate for commercial thermoelectric application in low‐grade waste heat harvest near room temperature, but the sharp drop of thermoelectric properties at higher temperature and weak mechanical strength in zone‐melted material are the main obstacles to its wide development for power generation. Herein, an effective approach is reported to improve the thermoelectric performance of p‐type Bi0.42Sb1.58Te3 hot‐pressed sample by incorporating Ag5SbSe4. A peak ZT of 1.40 at 375 K and a high average ZT of 1.25 between 300 and 500 K are achieved. Such outstanding thermoelectric performance originates from the synergistic effects of improved density‐of‐states effective mass, reduced bipolar thermal conductivity by the boosted carrier concentration, and suppressed lattice thermal conductivity by the induced phonon scattering centers including substitute point defects, dislocations, stress–strain clusters, and grain boundaries. Comprised of the p‐type Bi0.42Sb1.58Te3 + 0.10 wt% Ag5SbSe4 and zone‐melted n‐type Bi2Te2.7Se0.3, the thermoelectric module exhibits a high conversion efficiency of 6.5% at a temperature gradient of 200 K, indicating promising applications for low‐grade heat harvest near room temperature.
Turning Silica into Enzymes by Hydrogenation: Simultaneously Achieving Oxygen Vacancy Engineering and Tumor Adaptive Accumulation for NIR‐II‐Potentiated Therapy
Authors: Liu Mengting , Ye Jin , Liu Shuang , Xu Xiuping , Cui Yujie , Qu Jiawei , Zhang Zhiyong , Zhang Kefen , Niu Na , Chen Ligang , Fu Yujie , Xu Jiating 
Published: August 2023

AbstractMolybdenum (Mo)‐based nanozymes have been attracting increasingly extensive attention in photocatalytic antitumor field due to their versatile physicochemical properties, whereas the limited light capture rate and high recombination rate of photogenerated carriers seriously impedes their further development. Herein, MoO3‐starring silica nanozymes with hyaluronic acid modification (HMMSNs@HA) are innovated by hydrogenation to simultaneously achieve oxygen vacancies (OVs) engineering and tumor adaptive accumulation for the second near‐infrared (NIR‐II, 1064 nm) light‐potentiated thermal‐catalytic therapy. The hydrogenation‐regulated OVs can narrow the band gap of HMMSNs from 2.66 to 1.16 eV, achieving optimal optical absorption in NIR‐II region. Additionally, HMMSNs hold high separation efficacy of electron‐hole pairs to facilitate the generation of reactive oxygen species under laser irradiation. Significantly, HMMSNs@HA are stable in tumor microenvironment, while can degrade in normal physiological conditions, thereby offering tumor‐adaptive accumulation. Synchrotron radiation‐based extended X‐ray absorption fine structure spectroscopy reveals that OVs enabling the Mo4+ and Mo5+ formation, which can react with tumor endogenous H2O2 to produce hydroxyl radicals. Furthermore, OVs‐induced localized surface plasmon resonance effect endows the nanozymes with photothermal conversion efficacy of 32.3%, which affords NIR‐II‐excited photonic hyperthermia‐enhances catalytic therapy. All the experimental results demonstrate the high safety and superiorities of HMMSNs@HA for NIR‐II‐initiate therapy.
Protein and Peptide‐Based Nanotechnology for Enhancing Stability, Bioactivity, and Delivery of Anthocyanins
Authors: Zhang Lei , Yao Liang , Zhao Feng , Yu Alice , Zhou Yueru , Wen Qingmei , Wang Jun , Zheng Tao , Chen Pu 
Published: August 2023

AbstractAnthocyanin, a unique natural polyphenol, is abundant in plants and widely utilized in biomedicine, cosmetics, and the food industry due to its excellent antioxidant, anticancer, antiaging, antimicrobial, and anti‐inflammatory properties. However, the degradation of anthocyanin in an extreme environment, such as alkali pH, high temperatures, and metal ions, limits its physiochemical stabilities and bioavailabilities. Encapsulation and combining anthocyanin with biomaterials could efficiently stabilize anthocyanin for protection. Promisingly, natural or artificially designed proteins and peptides with favorable stabilities, excellent biocapacity, and wide sources are potential candidates to stabilize anthocyanin. This review focuses on recent progress, strategies, and perspectives on protein and peptide for anthocyanin functionalization and delivery, i.e., formulation technologies, physicochemical stability enhancement, cellular uptake, bioavailabilities, and biological activities development. Interestingly, due to the simplicity and diversity of peptide structure, the interaction mechanisms between peptide and anthocyanin could be illustrated. This work sheds light on the mechanism of protein/peptide–anthocyanin nanoparticle construction and expands on potential applications of anthocyanin in nutrition and biomedicine.
High‐Performance Liquid‐Repellent and Thermal–Wet Comfortable Membranes Using Triboelectric Nanostructured Nanofiber/Meshes
Authors: Gong Xiaobao , Ding Mingle , Gao Ping , Liu Xiaoyan , Yu Jianyong , Zhang Shichao , Ding Bin 
Published: August 2023

AbstractSkin‐like functional membranes with liquid resistance and moisture permeability are in growing demand in various applications. However, the membranes have been facing a long‐term dilemma in balancing waterproofness and breathability, as well as resisting internal liquid sweat transport, resulting in poor thermal–wet comfort. Herein, a novel electromeshing technique, based on manipulating the ejection and phase separation of charged liquids, is developed to create triboelectric nanostructured nano‐mesh consisting of hydrophobic ferroelectric nanofiber/meshes and hydrophilic nanofiber/meshes. By combining the true nanoscale diameter (≈22 nm), small pore size, and high porosity, high waterproofness (129 kPa) and breathability (3736 g m−2 per day) for the membranes are achieved. Moreover, the membranes can break large water clusters into small water molecules to promote sweat absorption and release by coupling hydrophilic wicking and triboelectric field polarization, exhibiting a satisfactory water evaporation rate (0.64 g h−1) and thermal–wet comfort (0.7 °C cooler than the cutting‐edge poly(tetrafluoroethylene) protective membranes). This work may shed new light on the design and development of advanced protective textiles.
Processable Hydroxide Ink with Oriented Microstructure
Authors: Xie Yuanyang , Yu Chang , Zhang Xiubo , Gu Guibin , Yu Jinhe , Yang Yi , Qiu Jieshan 
Published: August 2023

AbstractThe intrinsic poor processability of hydroxide originating from the structural property greatly hinders their practical applications. Here, a processable highly‐concentrated nickel/cobalt double hydroxide ink is reported to meet the practical demand. The inner nanoflakes in ink possess a high width/thickness ratio (>100), which endows the highly‐concentrated ink (60 mg mL−1) with liquid‐like rheology properties. Further, the elliptical diffusive arc in small‐angle X‐ray scattering pattern and porous and ordered alignment morphology in cryogenic temperature scanning electron microscopy confirms the locally oriented arrangement of nanoflakes in the ink. Benefiting from this interior‐ordered structure, the ink can be processed into meter‐level film, continuous yarn, and rigid and free‐standing aerogel, respectively. In particular, the films can be used as electrodes directly in aqueous zinc ion batteries and deliver a favorable capacity (382 mAh g−1 @ 200 mA g−1) as well as long cycle stability (capacity retention rate of 88% @ 1000 mA g−1 after 400 cycles). Moreover, the enlarged‐batched fabrication with the introduction of efficient thermal conduction in a 10 L reactor is also carried out successfully. These results clarify the inner relationship between microstructure‐rheology and mechanical engineering for hydroxides, thus paving the way to develop hydroxide‐based products for future practical applications.
Plasmonic Metasurfaces with Quality Factors Up to 790 in the Visible Regime
Authors: Li Guangyuan , Du Xiang , Xiong Lei , Yang Xiuhua 
Published: August 2023

AbstractPlasmon metasurfaces supporting surface lattice resonances (SLRs) have emerged as an exciting platform for manipulating nanoscale light‐matter interactions in expanding applications. Although great progress has been achieved, the quality factors of plasmonic metasurfaces remain quite limited especially in the visible regime, hindering practical applications. This study reports an SLR‐based plasmonic metasurface with an ultrahigh quality factor that reaches 1427 in theory and 790 in experiments at 712 nm, a 240% increase over the state of the art. The quality factor of the out‐of‐plane SLR in periodic gold or silver nanorods is augmented by an order of magnitude through reducing the nanorod height from 100 to 50 nm. With these findings, this work is expected to pave the way for realizing high‐performance nanolasers, nonlinear frequency converters, and biosensors based on ultrahigh‐Q plasmonic metasurfaces.
Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
Authors: Singh Sunil , Machida Satoru , Tulsian Nikhil Kumar , Choong Yeu Khai , Ng Joel , Shankar Srihari , Liu Yaochen , Chandiramani Krisha Vashdev , Shi Jian , Sivaraman J 
Published: August 2023

AbstractHACE1 is an ankyrin repeat (AKR) containing HECT‐type E3 ubiquitin ligase that interacts with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor, its structure and mode of ubiquitination are not understood. The authors present the cryo‐EM structures of human HACE1 along with in vitro functional studies that provide insights into how the enzymatic activity of HACE1 is regulated. HACE1 comprises of an N‐terminal AKR domain, a middle (MID) domain, and a C‐terminal HECT domain. Its unique G‐shaped architecture interacts as a homodimer, with monomers arranged in an antiparallel manner. In this dimeric arrangement, HACE1 ubiquitination activity is hampered, as the N‐terminal helix of one monomer restricts access to the C‐terminal domain of the other. The in vitro ubiquitination assays, hydrogen‐deuterium exchange mass spectrometry (HDX–MS) analysis, mutagenesis, and in silico modeling suggest that the HACE1 MID domain plays a crucial role along with the AKRs in RAC1 substrate recognition.
SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle
Authors: She Xiaowei , Wu Qi , Rao Zejun , Song Da , Huang Changsheng , Feng Shengjie , Liu Anyi , Liu Lang , Wan Kairui , Li Xun , Yu Chengxin , Qiu Cheng , Luo Xuelai , Hu Junbo , Wang Guihua , Xu Feng , Sun Li 
Published: August 2023

AbstractMCT1 is a critical protein found in monocarboxylate transporters that plays a significant role in regulating the lactate shuttle. However, the post‐transcriptional modifications that regulate MCT1 are not clearly identified. In this study, it is reported that SETDB1 interacts with MCT1, leading to its stabilization. These findings reveal a novel post‐translational modification of MCT1, in which SETDB1 methylation occurs at K473 in vitro and in vivo. This methylation inhibits the interaction between MCT1 and Tollip, which blocks Tollip‐mediated autophagic degradation of MCT1. Furthermore, MCT1 K473 tri‐methylation promotes tumor glycolysis and M2‐like polarization of tumor‐associated macrophages in colorectal cancer (CRC), which enhances the lactate shuttle. In clinical studies, MCT1 K473 tri‐methylation is found to be upregulated and positively correlated with tumor progression and overall survival in CRC. This discovery suggests that SETDB1‐mediated tri‐methylation at K473 is a vital regulatory mechanism for lactate shuttle and tumor progression. Additionally, MCT1 K473 methylation may be a potential prognostic biomarker and promising therapeutic target for CRC.
Bottom‐Up Photosynthesis of an Air‐Stable Radical Semiconductor Showing Photoconductivity to Full Solar Spectrum and X‐Ray
Authors: Zhang Yu , Yan Yun‐Fan , Mi Jia‐Rong , Wang Shuai‐Hua , Wang Ming‐Sheng , Guo Guo‐Cong 
Published: August 2023

AbstractSingle‐component semiconductors with photoresponse to full solar spectrum are highly desirable to simplify the device structure of commercial photodetectors and to improve solar conversion or photocatalytic efficiency but remain scarce. This work reports bottom‐up photosynthesis of an air‐stable radical semiconductor using BiI3 and a photochromism‐active benzidine derivative as a photosensitive functional motif. This semiconductor shows photoconductivity to full solar spectrum contributed by radical and non‐radical forms of the benzidine derivative. It has also the potential to detect X‐rays because of strong X‐ray absorption coefficient. This finding opens up a new synthetic method for radical semiconductors and may find applications on extending photoresponsive ranges of perovskites, transition metal sulfides, and other materials.
Synergistic γ‐In2Se3@rGO Nanocomposites with Beneficial Crystal Transformation Behavior for High‐Performance Sodium‐Ion Batteries
Authors: Zhao Yun , Zhang Haoyue , Li Yong , Ma Canliang , Tian Wenjuan , Qi Xingguo , Han Gaoyi , Shao Zongping 
Published: August 2023

AbstractCrystal transformation of metal compound cathodes during charge/discharge processes in alkali metal‐ion batteries usually generates profound impact on structural stability and electrochemical performance, while the theme in anode materials, which always occurs and completes during the first redox cycle, is rarely explored probably due to the fast transformation dynamics. Herein, for the first time, a unique crystal transformation behavior with slow dynamics in anode of sodium‐ion batteries (SIBs) is reported, which further promotes electrochemical performance. Specifically, irreversible γ → β crystal transformation of In2Se3 is observed, induced by the persistent size degradation of In2Se3 particles during repeated sodiation/desodiation, supported by a series of ex situ characterizations, such as HRTEM, XRD, and XPS of γ‐In2Se3/reduced graphene oxide (γ‐In2Se3@rGO) nanocomposite. The hybrid electrode shows ultrahigh long‐term cycling stability (378 mA h g−1 at 1.0 A g−1 after 1000 cycles) and excellent rate capability (272 mA h g−1 at 20.0 A g−1). Full battery with Na3V2(PO4)3 cathode also manifests superior performance, promising β‐In2Se3 dominated electrode materials in high‐power and long‐life SIBs. The first‐principle calculations suggest the crystal transformation enhances electric conductivity of β‐In2Se3 and facilitates its accessibility to sodium. In combination with the synergistic effect between rGO matrix, substantially enhanced electrochemical performance is realized.
Increasing the Magnetic Blocking Temperature of Single‐Molecule Magnets
Authors: Vieru Veacheslav , Gómez‐Coca Silvia , Ruiz Eliseo , Chibotaru Liviu F. 
Published: August 2023

AbstractThe synthesis of single‐molecule magnets (SMMs), magnetic complexes capable of retaining magnetization blocking for a long time at elevated temperatures, has been a major concern for magnetochemists over the last three decades. In this review, we describe basic SMMs and the different approaches that allow high magnetization‐blocking temperatures to be reached. We focus on the basic factors affecting magnetization blocking, magnetic axiality and the height of the blocking barrier, which can be used to group different families of complexes in terms of their SMM efficiency. Finally, we discuss several practical routes for the design of mono‐ and polynuclear complexes that could be applied in memory devices.
Mesoionische N‐Heterocyclische Olefine verschieben die obere Grenze der Nucleophilie‐Skala
Authors: Eitzinger Andreas , Reitz Justus , Antoni Patrick W. , Mayr Herbert , Ofial Armin R. , Hansmann Max M. 
Published: August 2023

AbstractMesoionische, 1,2,3‐Triazol‐abgeleitete N‐heterocyclische Olefine (mNHOs) mit außerordentlich elektronenreicher, exocyclischer CC–Doppelbindung wurden synthetisiert und spektroskopisch charakterisiert, z. T. durch Röntgenstrukturanalyse. Die Kinetik der mNHO‐Reaktionen mit Arylidenmalonaten (ArCH=C(CO2Et)2) zu zwitterionischen Addukten wurde photometrisch in THF bei 20 °C verfolgt. Die resultierenden Geschwindigkeitskonstanten 2. Ordnung k2(20 °C) korrelieren linear mit zuvor bestimmten Elektrophilieparametern E der Arylidenmalonate (Referenzelektrophile) und liefern gemäß der Beziehung lg k2(20 °C)=sN(N+E) die nucleophilspezifischen N‐ und sN‐Parameter der mNHOs. Die mNHOs sind mit 21<N<32 viel stärkere Nucleophile als herkömmliche NHOs. Einige mNHOs übertreffen sogar die Reaktivität von mono‐ und diakzeptor‐substituierten Carbanionen. Es wird an Beispielen gezeigt, dass es die so bestimmten Reaktivitätsparameter ermöglichen, die Geschwindigkeitskonstanten für mNHO‐Reaktionen mit weiteren Michael‐Akzeptoren zu berechnen. Auch die Reaktionen mit anderen elektrophilen Reaktionspartnern, inklusive Kohlenstoffdioxid, das zwitterionische mNHO‐Carboxylate bildet, lassen sich vorhersagen. Die Nucleophilie‐Parameter N korrelieren linear mit einer Linearkombination der quantenchemisch berechneten Methylkation‐Affinitäten und %Vbur („buried volumes“) der mNHOs, was ein wertvolles Werkzeug liefert, um Reaktivitäten starker Kohlenstoff‐Nucleophile maßzuschneidern.
Correspondence on “Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1”
Authors: Zhang Lixin , Liu Xueting , Wang Xinye , Zhu Guoliang , Song Heng , Cheng Ronghai , Naowarojna Nathchar , Costello Catherine E. , Liu Pinghua 
Published: August 2023

AbstractIn their recent Angewandte Chemie publication (doi: 10.1002/anie.202112063), Cen, Wang, Zhou et al. reported the crystal structure of a ternary complex of the non‐heme iron endoperoxidase FtmOx1 (PDB entry 7ETK). The biochemical data assessed in this study were from a retracted study (doi: 10.1038/nature15519) by Zhang, Liu, Zhang et al.; no additional biochemical data were included, yet there was no discussion on the source of the biochemical data in the report by Cen, Wang, Zhou et al. Based on this new crystal structure and subsequent QM/MM‐MD calculations, Cen, Wang, Zhou et al. concluded that their work provided evidence supporting the CarC‐like mechanistic model for FtmOx1 catalysis. However, the authors did not accurately describe either the CarC‐like model or the COX‐like model, and they did not address the differences between them. Further, and contrary to their interpretations in the manuscript, the authors’ data are consistent with the COX‐like model once the details of the CarC‐like and COX‐like models have been carefully analyzed.
Acidic Hydrogen Evolution Electrocatalysis at High‐Entropy Alloys Correlates with its Composition‐Dependent Potential of Zero Charge
Authors: Kim Moonjoo , Batsa Tetteh Emmanuel , Krysiak Olga A. , Savan Alan , Xiao Bin , Piotrowiak Tobias Horst , Andronescu Corina , Ludwig Alfred , Dong Chung Taek , Schuhmann Wolfgang 
Published: August 2023

AbstractThe vast possibilities in the elemental combinations of high‐entropy alloys (HEAs) make it essential to discover activity descriptors for establishing rational electrocatalyst design principles. Despite the increasing attention on the potential of zero charge (PZC) of hydrogen evolution reaction (HER) electrocatalyst, neither the PZC of HEAs nor the impact of the PZC on the HER activity at HEAs has been described. Here, we use scanning electrochemical cell microscopy (SECCM) to determine the PZC and the HER activities of various elemental compositions of a Pt−Pd−Ru−Ir−Ag thin‐film HEA materials library (HEA‐ML) with high statistical reliability. Interestingly, the PZC of Pt−Pd−Ru−Ir−Ag is linearly correlated with its composition‐weighted average work function. The HER current density in acidic media positively correlates with the PZC, which can be explained by the preconcentration of H+ in the electrical double layer at potentials negative of the PZC.
Different aspects of polymer films based on low‐density polyethylene using graphene as filler
Authors: Medeiros Gabriela S. , Nisar Muhammad , Peter Jakub , Andrade Ricardo J. E. , Fechine Guilhermino J. M. 
Published: August 2023

AbstractThe focus of the present work is to prepare low‐density polyethylene (LDPE)‐graphene (G) nanocomposite films with improved gas barrier properties by melt extrusion. A narrow range of the graphene (0.05–0.3 wt.%) as filler was used in the LDPE matrix. The rheological analysis indicating that there is no significant influence on the LDPE chains mobility with the addition of filler. The nanocomposites percent crystallinity (Xc%) increase from 25.0% to 31.6% compared to neat LDPE. The X‐ray diffractogram shows a change in width half height of the peak positioned at 26° ((002) plane) from 0.69 (graphite) to 1.24 (graphene), revealing the asymmetry of this plane. The optical microscopy images show a good dispersion of the nanoparticles in the polymer matrix. The mechanical properties of the nanocomposites in longitudinal direction demonstrate better improvement with addition of the filler as compared to the transverse direction. The contact angle measurements of nanocomposites for water and ethylene glycol do not shows a significant variation in comparison to neat LDPE. The nanocomposites show 26% enhancement in the oxygen barrier property. Thus, here we present the cost‐effective LDPE‐graphene nanocomposites with improve oxygen barrier property, which can be used in different industrial application especially in food packaging.