bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective in vitro A431 cell line anticancer efficacy of zirconia nanoflakes derived from Enicostemma littorale aqueous extract
Authors: Sumathi Paramasivam , Renuka Navaneethan , Subramanian Ramasamy , Periyasami Govindasami , Rahaman Mostafizur , Karthikeyan Perumal 
Published: June 2023

AbstractBiomedical applications of zirconia nanomaterials were limited in biological systems. In this research, 8–15 nm size zirconia nanoflakes (ZrNFs) were fabricated and their nature, morphology, and biocompatibility were evaluated. The synthesis was carried out using Enicostemma littorale plant extract as an effective reducing and capping agent. Physiochemical properties of prepared ZrNFs were characterized using diverse instrumental studies such as UV‐vis spectrophotometer, Fourier‐transform infrared, powder X‐ray diffractometer, scanning electron microscope, transmission electron microscope (TEM), energy dispersive X‐ray, and cyclic voltammetry (CV). The XRD pattern confirmed the tetragonal phases of ZrNFs and the highest crystallite size of Zr0.02, Zr0.02, and Zr0.06 was 56, 50, and 44 nm, respectively. The morphology of samples was assessed using TEM. Electrophysiological effects of ZrNFs in the cellular interaction process were revealed by the slower rate of electron transfer results in CV demonstration. Biocompatibility of synthesized ZrNFs was studied on A431 human epidermoid carcinoma epithelial cells. The cell viability was increased with an increasing the concentration of nanoflakes up to 6.50–100 μg/mL. The cell viability and observed IC50 values (44.25, 36.49, and 39.62 μg/mL) reveals that the synthesized ZrNFs using E. littorale extract is found to be efficient toxic to A431 cancer cell lines.
Stimuli‐Responsive Prodrug Chemistries for Cancer Therapy
Authors: Bargakshatriya Rupa , Pramanik Sumit Kumar 
Published: June 2023

AbstractProdrugs are pharmacologically inactive, chemically modified derivatives of active drugs, which, following in vivo administration, are converted to the parent drugs through chemical or enzymatic cleavage. The prodrug approach holds tremendous potential to create the enhanced version of an existing pharmacological agent and leverage those improvements to augment the drug molecules′ bioavailability, targeting ability, therapeutic efficacy, safety, and marketability. Especially in cancer therapy, prodrug application has received substantial attention. A prodrug can effectively broaden the therapeutic window of its parent drug by enhancing its release at targeted tumor sites while reducing its access to healthy cells. The spatiotemporally controlled release can be achieved by manipulating the chemical, physical, or biological stimuli present at the targeted tumor site. The critical strategy comprises drug‐carrier linkages that respond to physiological or biochemical stimuli in the tumor milieu to yield the active drug form. This review will focus on the recent advancements in the development of various fluorophore‐drug conjugates that are widely used for real‐time monitoring of drug delivery. The use of different stimuli‐cleavable linkers and the mechanisms of linker cleavage will be discussed. Finally, the review will conclude with a critical discussion of the prospects and challenges that might impede the future development of such prodrugs.
Pseudo‐infarction electrocardiographic changes in delayed onset hypoparathyroidism: A case report
Authors: Chow Han Bing , Lim Caryn Tsujean , Ho Yik Hon , Cham Yee Ling , Fong Alan Yean Yip , Said Asri , Ong Tiong Kiam 
Published: June 2023

Key Clinical MessageThe high‐risk “Shark Fin” electrocardiogram (ECG) pattern has been associated with transmural ischemia but can also result from electrolyte anomalies. Therefore, the decision for invasive coronary catheterization requires a detailed history and dedicated biochemical tests.AbstractPseudo‐infarction ECG pattern resembling “Shark Fin” was demonstrated in a 76‐year‐old lady with a previous total thyroidectomy who presented with unspecific symptoms. An incidental finding of hypokalemia and hypocalcemia was thought to be related to delayed onset hypoparathyroidism. Potential etiologies like coronary vasospasm and catecholamine‐associated myocardial injury were suggested.
ANCA‐associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: Case report and literature review
Authors: Matsuo Toshihiko , Hiramatsu‐Asano Sumie , Sawachika Hiroshi , Nishimura Hirotake 
Published: June 2023

Key Clinical MessagePatients with antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis, specifically with myeloperoxidase (MPO)‐ANCA, would have a risk for developing corneal melt and perforation abruptly in a short period. It is desirable to have a team of collaboration of rheumatologists and other specialties.AbstractAn 80‐year old man who had been diagnosed 5.5 years previously as ANCA‐associated vasculitis by temporal artery biopsy developed corneal melt and perforation with scleritis in both eyes. He underwent successful cataract surgery and retained ambulatory vision with the aid of intravenous rituximab. Two additional patients with similar manifestations were found in the literature.
Rational Design of Liquid Metal Organic Frameworks for the Enhanced CO2 Absorption and Their Photocatalytic Reduction
Authors: Li Yanru , Zhuang Lingyi , Tan Li , Chen Qiao , Fang Yuanxing 
Published: June 2023

AbstractMetal organic frameworks (MOFs) has been widely investigated as co‐catalysts for photocatalysis owing to their unique property for controlling the reaction kinetics. They are generally presented in a solid state. Recent studies have presented MOF in the liquid phase, meanwhile preserving the framework structure. Acting as a co‐catalyst, significantly improved efficiency has been realized for photocatalytic CO2 reduction. This concept article focuses on the chemical principle of liquid MOF (LMOF). Their applications in photocatalysis and CO2 adsorption have been discussed with showing key examples. In addition, the other relevant applications of LMOF have been presented.
Catalytic Carbonylation of Acrylic Acid to Succinic Anhydride**
Authors: Pietraru Marie‐Hélène , Lentz Nicolas , Ponsard Louise , Nicolas Emmanuel , Cantat Thibault 
Published: June 2023

AbstractAlternative sources for polymeric materials have been sought in the past few years to reduce our dependence on fossil feedstock. We report the catalytic carbonylation of acrylic acid, a platform chemical that can be bio‐sourced, as a new pathway toward the formation of a useful monomer to polyesters, namely succinic anhydride. The novel system reported herein tackles the difficult carbonylation of unsaturated carboxylic acids through the utilization of an Earth‐abundant metal catalyst, [Co2(CO)8], in presence of a bidentate ligand, 1,2‐bis(dicyclohexylphosphino)ethane (dcpe), and H2. We investigated the influence of the reaction conditions through the variations of metal, ligand, temperature, pressure, and gas composition. The carbonylative ring‐closure of acrylic acid was successfully obtained in high yield and selectivity toward the formation of succinic anhydride using mild conditions (90 °C and 16 bar of CO/H2 95 : 5).
Effect of Synthetic Conditions on the Structure and Properties of Nb14W3O44 Anode for Lithium‐Ion Batteries
Authors: Li Longsheng , Kang Jiankai , Yang Wei , Zou Hanbo , Chen Shengzhou 
Published: June 2023

AbstractNiobium tungsten oxide is a potential replacement for graphite in fast‐charge lithium‐ion batteries due to its high rate performance and high stability. Herein, Nb14W3O44 anode was synthesized by hydrothermal reaction of niobium oxalate and ammonium tungstate and sequent calcination of niobium tungsten oxide precursors. Compared with the traditional solid‐state method, the particle size and calcination time of Nb14W3O44 obtained by the modified method are greatly reduced. Through orthogonal experiments, the optimal synthesis conditions were determined, and it was found that hydrothermal conditions have an important influence on the particle size of the final product, while the calcination temperature and time greatly affect the purity of the product and thus influence its specific capacity during cycles.
Covalent Organic Framework‐Supported Metallocene for Ethylene Polymerization
Authors: Zhu Bangban , Liu Kan , Luo Liqiong , Zhang Ziyang , Xiao Yangke , Sun Minghao , Jie Suyun , Wang Wen‐Jun , Hu Jijiang , Shi Shengbin , Wang Qingyue , Li Bo‐Geng , Liu Pingwei 
Published: June 2023

AbstractThe loading of homogeneous catalysts with support can dramatically improve their performance in olefin polymerization. However, the challenge lies in the development of supported catalysts with well‐defined pore structures and good compatibility to achieve high catalytic activity and product performance. Herein, we report the use of an emergent class of porous material—covalent organic framework material (COF) as a carrier to support metallocene catalyst—Cp2ZrCl2 for ethylene polymerization. The COF‐supported catalyst demonstrates a higher catalytic activity of 31.1×106 g mol−1 h−1 at 140 °C, compared with 11.2×106 g mol−1 h−1 for the homogenous one. The resulting polyethylene (PE) products possess higher weight‐average molecular weight (Mw) and narrower molecular weight distribution (Ð) after COF supporting, that is, Mw increases from 160 to 308 kDa and Ð drops from 3.3 to 2.2. The melting point (Tm) is also increased by up to 5.2 °C. Moreover, the PE product possesses a characteristic filamentous microstructure and demonstrates an increased tensile strength from 19.0 to 30.7 MPa and elongation at break from 350 to 1400 % after catalyst loading. We believe that the use of COF carriers will facilitate the future development of supported catalysts for highly efficient olefin polymerization and high‐performance polyolefins.
A 2,2‐Difluoroimidazolidine Derivative for Deoxyfluorination Reactions: Mechanistic Insights by Experimental and Computational Studies
Authors: Herbstritt Domenique , Tomar Pooja , Müller Robert , Kaupp Martin , Braun Thomas 
Published: June 2023

AbstractA N‐heterocyclic deoxyfluorinating agent SIMesF2 was synthesized by nucleophilic fluorination of N,N‐1,3‐dimesityl‐2‐chloroimidazolidinium chloride (3) at room temperature. SIMesF2 was applied to deoxyfluorinate carboxylic acids and alcohols and convert benzaldehyde into difluorotoluene. Mechanistic studies by NMR spectroscopy suggest reaction pathways of the carboxylic acid to acyl fluoride via outer‐sphere fluorinations at an imidazolidinium ion by polyfluoride. DFT studies give further insight by exploring mechanistic details which distinguish the fluorination of aldehydes from that of carboxylic acids. Furthermore, a consecutive reaction sequence for the oxidation of an aldehyde followed by in situ fluorination of the generated carboxylic acid was developed.
The added value of hypertonic saline solution to furosemide monotherapy in patients with acute decompensated heart failure: A meta‐analysis and trial sequential analysis
Authors: Diaz‐Arocutipa Carlos , Denegri‐Galvan Jack , Vicent Lourdes , Pariona Marcos , Mamas Mamas A. , Hernandez Adrian V. 
Published: June 2023

AbstractWe assessed the effects of hypertonic saline solution (HSS) plus furosemide versus furosemide alone in patients with acute decompensated heart failure (ADHF). We searched four electronic databases for randomized controlled trials (RCTs) until June 30, 2022. The quality of evidence (QoE) was assessed using the GRADE approach. All meta‐analyses were performed using a random‐effects model. A trial sequential analysis (TSA) was also conducted for intermediate and biomarker outcomes. Ten RCTs involving 3013 patients were included. HSS plus furosemide significantly reduced the length of hospital stay (mean difference [MD]: −3.60 days; 95% confidence interval [CI]: −4.56 to −2.64; QoE: moderate), weight (MD: −2.34 kg; 95% CI: −3.15 to −1.53; QoE: moderate), serum creatinine (MD: −0.41 mg/dL; 95% CI: −0.49 to −0.33; QoE: low), and type‐B natriuretic peptide (MD: −124.26 pg/mL; 95% CI: −207.97 to −40.54; QoE: low) compared to furosemide alone. HSS plus furosemide significantly increased urine output (MD: 528.57 mL/24 h; 95% CI: 431.90 to 625.23; QoE: moderate), serum Na+ (MD: 6.80 mmol/L; 95% CI: 4.92 to 8.69; QoE: low), and urine Na+ (MD: 54.85 mmol/24 h; 95% CI: 46.31 to 63.38; QoE: moderate) compared to furosemide alone. TSA confirmed the benefit of HSS plus furosemide. Due to the heterogeneity in mortality and heart failure readmission, meta‐analysis was not performed. Our study shows that HSS plus furosemide, compared to furosemide alone, improved surrogated outcomes in ADHF patients with low or intermediate QoE. Adequately powered RCTs are still needed to assess the benefit on heart failure readmission and mortality.
Prediction of IDO1 Inhibitors by a Fingerprint‐Based Stacking Ensemble Model Named IDO1Stack
Authors: Sun Huimin , Yang Qing , Yu Xinxin , Huang Mengting , Ding Meng , Li Weihua , Tang Yun , Liu Guixia 
Published: June 2023

AbstractIndoleamine 2,3‐dioxygenase 1 (IDO1) is viewed as an extremely promising target for cancer immunotherapy. Here, we proposed a two‐layer stacking ensemble model, IDO1Stack, that can efficiently predict IDO1 inhibitors. First, we constructed a series of classification models based on five machine learning algorithms and eight molecular characterization methods. Then, a stacking ensemble model was built using the top five models as the base classifier and logistic regression as the meta‐classifier. The areas under the receiver operating characteristic curve (AUC) of IDO1Stack on the test set and external validation set were 0.952 and 0.918, respectively. Furthermore, we computed the applicability domain and privileged substructures of the model and interpreted the model using SHapley Additive exPlanations (SHAP). It is expected that IDO1Stack can well study the interaction between target and ligand, providing practitioners with a reliable tool for rapid screening and discovery of IDO1 inhibitors.
Usefulness of three‐dimensional thoracoscope for prone position thoracoscopic esophagectomy improves mediastinal lymph node dissection and prognosis for esophageal cancer
Authors: Kanamori Kohei , Koyanagi Kazuo , Ozawa Soji , Oguma Junya , Kazuno Akihito , Ninomiya Yamato , Yamamoto Miho , Shoji Yoshiaki , Yatabe Kentaro , Mori Masaki 
Published: June 2023

AbstractObjectivesThis study aimed to assess the superiority of 3D flexible thoracoscope against 2D thoracoscope for lymph node dissection (LND) and prognosis for prone‐position thoracoscopic esophagectomy (TE) in esophageal cancer.MethodsThree hundred and sixty‐seven esophageal cancer patients who underwent prone‐position TE with 3‐field LND between 2009 and 2018 were evaluated. 2D and 3D thoracoscope was used in 182 (2D group) and 185 cases (3D group), respectively. Short‐term surgical outcomes, numbers of retrieved mediastinal lymph node (LN), and rates of LN recurrence were compared. Risk factors for mediastinal LN recurrence and long‐time prognosis were also evaluated.ResultsNo differences in postoperative complications were observed between the groups. The numbers of retrieved mediastinal LN were significantly higher, and the rates of LN recurrence were significantly lower in the 3D group compared to 2D group. Use of 2D thoracoscope was a significant independent factor of middle mediastinal LN recurrence by multivariable analysis. Survival was compared by cox regression analysis, and the 3D group had a significantly better prognosis than the 2D group.ConclusionsProne position TE using 3D thoracoscope may improve the accuracy of mediastinal LND and prognosis without increasing postoperative complications for esophageal cancer.
Solar photovoltaic‐interfaced shunt active power filter implementation for power quality enhancement in grid‐connected systems
Authors: Boopathi Rajendran , Indragandhi Vairavasundaram 
Published: June 2023

SummaryThis paper proposes a synchronous reference frame (SRF) control with a photovoltaic (PV)‐based shunt active power filter (SAPF) that is utilized to mitigate harmonics impacted by fast‐growing nonlinear load (NL), including compensation of reactive power in distribution systems. The PV module is constructed with an enhanced incremental conductance (EINC) maximum power point tracking approach with an interconnected SAPF. It can support load reactive power demand, eliminating harmonics obtained by NL and the active power supported by the PV arrays. Traditional tuning PI controllers perform poorly under variable load conditions. An adaptive intelligent nonlinear controller capable of simultaneously addressing the impacts of variable load, NL generation of harmonic current, and reactive power demand. This research aims to improve power quality based on an adaptive neuro‐fuzzy inference system (ANFIS) to enhance PV‐SAPF dynamic performance and achieve optimized performance. This control technique reduces the percentage of total harmonic distortion (THD) of the source current below IEEE standards from generating an NL and balanced/unbalanced load condition and regulates the DC‐link voltage constant. Moreover, the presented SRF theory, solar PV, and step‐up converter are addressed. The proposed system control strategy is implemented in the MATLAB/Simulink platform and the Texas Instruments Cyclone IV EP4CE30F484 FPGA board to carry out the hardware implementations of the proposed PV‐SAPF system and validated experimentally.
Miniaturized six‐ring elliptical monopole‐based MIMO antenna for ultrawideband applications
Authors: Amroun A. , Zebiri C. , Sayad Djamel , Elfergani Issa T. E. , Desai A. , Bouknia M. L. , Zegadi R. , Rodriguez J. 
Published: June 2023

SummaryThis paper proposes a miniature two‐element Multiple Input Multiple Output (MIMO) antenna dedicated to UWB applications. The proposed MIMO design has a very low profile of 30 × 20 × 1.6 mm3. The proposed antenna is carefully designed and optimized using HFSS simulation software. As a proof of concept, the proposed design is realized and experimentally tested for MIMO applications. The proposed structure, printed on an FR4 substrate, comprises two symmetrical elliptical conductive patches on the upper side and a modified ground plane on the lower one. Each radiating element includes six elliptical rings. The modified ground plane consists of a T‐shaped strip and two semielliptical slots etched opposite the feed line. All the parameters of the design are carefully optimized to achieve an ultrawide bandwidth antenna spanning from (136.08%) 3.1 to 16.3 GHz. The results are discussed and analyzed in terms of bandwidth, gain, efficiency, radiation pattern, diversity gain, envelope correlation coefficient (ECC), total active reflection coefficient (TARC), and mean effective gain (MEG). All simulated results are found to be in good accordance with experiments. The design reveals attractive features for UWB applications. A good isolation (17 dB) between the two radiators is achieved despite the close proximity using the suggested ground plane geometry.
Early adversity changes the economic conditions of mouse structural brain network organization
Authors: Carozza Sofia , Holmes Joni , Vértes Petra E. , Bullmore Ed , Arefin Tanzil M. , Pugliese Alexa , Zhang Jiangyang , Kaffman Arie , Akarca Danyal , Astle Duncan E. 
Published: June 2023

AbstractEarly adversity can change educational, cognitive, and mental health outcomes. However, the neural processes through which early adversity exerts these effects remain largely unknown. We used generative network modeling of the mouse connectome to test whether unpredictable postnatal stress shifts the constraints that govern the organization of the structural connectome. A model that trades off the wiring cost of long‐distance connections with topological homophily (i.e., links between regions with shared neighbors) generated simulations that successfully replicate the rodent connectome. The imposition of early life adversity shifted the best‐performing parameter combinations toward zero, heightening the stochastic nature of the generative process. Put simply, unpredictable postnatal stress changes the economic constraints that reproduce rodent connectome organization, introducing greater randomness into the development of the simulations. While this change may constrain the development of cognitive abilities, it could also reflect an adaptive mechanism that facilitates effective responses to future challenges.
Effect of thyroid hormones administration on urinary endogenous steroid profile of the athlete biological passport
Authors: Martínez_Brito Dayamin , de la Torre Xavier , Botrè Francesco 
Published: June 2023

AbstractThis work focused on the possible alterations of the markers of the steroidal module of the athlete biological passport, considering samples of athletes declaring and not‐declaring the supplementation of thyroid hormones (TH) in the Doping Control Form (DCF). Concentrations of 5α‐androstane‐3α,17β‐diol (5α‐Adiol), 5β‐androstane‐3α,17β‐diol (5β‐Adiol), testosterone (T), androsterone (A), etiocholanolone (Etio), epitestosterone (E), pregnanediol (PD), dehydroepiandrosterone (DHEA), and 11β‐hydroxy‐androsterone (OHA) were calculated using internal standards and external calibration by gas chromatography‐tandem mass spectrometry. Also, ratios between the above biomarkers were also estimated. The data set was composed of samples from females and males declaring and not‐declaring TH supplementation in the DCF. To corroborate these observations, a controlled urinary excretion study was carried out with multiple doses of sodium liothyronine (T3). Female data showed significant differences for the concentrations of 5α‐Adiol, A, DHEA, E, OHA, and T and the ratio A/Etio between FD and FND groups, whereas the male groups only showed significant differences in OHA concentration. In both cases, males and females declaring the consumption of levothyroxine showed narrower data distribution and diminished percentiles from 17% to 67% with respect to the not‐declaring corresponding groups (p < 0.05). Concentrations of 5α‐metabolites showed a higher depression for the FND, and both FD and MD groups showed a peculiar behavior for the PD concentrations. The controlled study agreed with the observations, mainly for the female group with significant differences for concentrations of E, Etio, 5α‐Adiol, and 5β‐Adiol after TH administration. The interpretation of the steroid markers of the ABP should consider TH administrations.