bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Therapeutic Targets for the Management of Diabetes
Mellitus Type 2
Authors: Prabhakar Pranav Kumar , Batiha Gaber El-Saber 
Published: May 2023

Abstract:
Diabetes is one of the lifelong chronic metabolic diseases which is prevalent
globally. There is a continuous rise in the number of people suffering from this disease with
time. It is characterized by hyperglycemia, which leads to severe damage to the body’s
system, such as blood vessels and nerves. Diabetes occurs due to the dysfunction of
pancreatic β -cell which leads to the reduction in the production of insulin or body cells
unable to use insulin produce efficiently. As per the data shared International diabetes
federation (IDF), there are around 415 million affected by this disease worldwide. There are
a number of hit targets available that can be focused on treating diabetes. There are many
drugs available and still under development for the treatment of type 2 diabetes. Inhibition
of gluconeogenesis, lipolysis, fatty acid oxidation, and glucokinase activator is emerging
targets for type 2 diabetes treatment. Diabetes management can be supplemented with drug
intervention for obesity. The antidiabetic drug sale is the second-largest in the world, trailing
only that of cancer. The future of managing diabetes will be guided by research on various
novel targets and the development of various therapeutic leads, such as GLP-1 agonists,
DPP-IV inhibitors, and SGLT2 inhibitors that have recently completed their different phases
of clinical trials. Among these therapeutic targets associated with type 2 diabetes, this
review focused on some common therapeutic targets for developing novel drug candidates
of the newer generation with better safety and efficacy.
Investigations on Cylindrical Surrounding Double-gate (CSDG) Mosfet using
ALXGA1-XAS/INP: PT with LA2O3 Oxide Layer for Fabrication
Authors: Gowthaman Naveenbalaji , Srivastava Viranjay M. 
Published: May 2023

Background/Introduction:
The Cylindrical Surrounding Double-Gate MOSFET has been
designed using Aluminium Gallium Arsenide in its arbitrary alloy form alongside Indium Phosphide
with Lanthanum Dioxide as a high-ƙ dielectric material.

Objective:
To conduct research on the novel application of AlxGa1-xAs/InP: Pt with La2O3 oxide layer in
the fabrication of Cylindrical Surrounding Double-gate (CSDG) MOSFET, with the ultimate goal of obtaining
patentable findings and developing intellectual property in the field. The heterostructure based
on the AlxGa1-xAs/InP: Pt has been used in the design and implementation of the MOSFET for RF applications.
Platinum serves as the gate material, which has higher electronic immunity toward the Short
Channel Effect and highlights semiconductor properties. The charge buildup is the main concern in the
field of MOSFET design when two different materials are considered for fabrication.

Methods:
The usage of 2 Dimensional Electron Gas has been outstanding in recent years to help the
electron buildup and charge carrier accumulation in the MOSFETs regime. Device simulation used for
the smart integral systems is an electronic simulator that uses the physical robustness and the mathematical
modeling of semiconductor heterostructures. In this research work, the fabrication method of Cylindrical
Surrounding Double Gate MOSFET has been discussed and realized. The scaling down of the
devices is essential to reduce the area of the chip and heat generation. By using these cylindrical structures,
the area of contact with the circuit platform is reduced since the cylinder can be laid down horizontally.

Results:
The coulomb scattering rate is observed to be 18.3 % lower than the drain terminal when compared
to the source terminal. Also, at x = 0.125 nm, the rate is 23.9 %, which makes it the lowest along
the length of the channel; at x = 1 nm, the rate is 1.4 % lesser than that of the drain terminal. A 1.4
A/mm2 high current density had been achieved in the channel of the device, which is significantly larger
than comparable transistors.

Conclusion:
The findings of this study reveal that the proposed cylindrical structures transistor, compared
to the conventional transistor, not only occupies a smaller area but also demonstrates enhanced
efficiency in RF applications. These results suggest the potential for patentable innovations in the field
of transistor design and fabrication, offering opportunities for intellectual property development and
commercialization.
Analisis Kebijakan Struktur Modal Berdasarkan Pot dan Tot Persepektif Ekonomi Syariah
Authors: Faizah Iva , Nurmalia Gustika 
Published: May 2023

<p><em><span>This study aims to look at the capital structure of firms listed on the JII index (Jakarta Islamic Index), whether to the Packing Order Theory, where the Packing Order Theory or POT is the theory of the company's capital structure in which the order of the company's capital structure is derived from 1). Corporate Internal Funds, 2). Debt and 3). Issuance of Shares. Meanwhile, Trade of Theory or TOT is a balancing between debt benefits and the use of debt will give advantage to the company itself in the form of Tax Shield or reduction of corporate tax burden. The object of this research is 13 companies that entered into JII Index during period december 2013 –November 2018 with 39 data that prossed The data were processed by multiple linear regression with the dependent variable in the form of Leverage Ratio proxied by Debt to Equity Ratio (DER) and Independent variable of Profitability and Liquidity Ratio both proxied in sequence with Return on Assets (ROA) and Currency Ratio (CR), which then analyzed with perspective Islamic economics. The result of research shows that the structure of capital of indexed companies in Jakarta Islamic Index is more likely to use the pattern of capital structure policy based on Packing Order Theory, where the proportion of Debt to Equity Ratio or proportion of debt to capital is not more than 50% in half of the listed companies.</span></em></p><p> </p>
V. V. Velyaminov-Zernov on Islam: Ryazan Local Lore Studies of the 19th Century
Authors: Kalimullina F. G. 
Published: May 2023

The article analyzes the four-volume work of the orientalist of the XIX century V. V. Velyaminov-Zernov “Research on the Kasimov tsars and tsarevichs” (1863–1887), dedicated to the history of the Kasimov Khanate. The main attention is paid to the local history material about the city of Kasimov of the 17–19th centuries, including its Muslim district. The paper reveals novelty of the scientist’s approaches to history of Kasimov Tatar community. The ﬁrst paragraph examines the conclusions of V. V. Velyaminov-Zernov regarding medieval fortresses located around Kasimov, the scientist concludes that these fortresses belonged to Tatar rulers during the period of the Kasimov Khanate. The second paragraph reveals the orientalist’s views on Orthodox-Muslim interaction in Kasimov in the 17–18th centuries. According to V. V. Velyaminov-Zernov, until the beginning of the 17th century there were two equivalent authorities in the city: the voivodeship court and the court of the Kasimov rulers. The article considers the history of Tatar heritage in Kasimov. The third paragraph is devoted to the 19th century. Velyaminov-Zernov’s research is useful for local historians dealing with the history of the Ryazan region.
Analisis Spasial Sebaran Sekolah Dasar Terdampak Bencana Gempa di Kecamatan Cugenang Kabupaten Cianjur
Authors: Setyawan Fani , Handayani Ayu , Maria Brigitta , Swandry Dedy , Somae Glendy , Wibowo Adi 
Published: April 2023

Sekolah merupakan salah satu prasarana yang berfungsi dalam pemenuhan kebutuhan pendidikan masyarakat dan lokasi pendirian sekolah harus memperhatikan kesesuaian karakteristik daerah. Gempa yang terjadi di Kabupaten Cianjur mengakibatkan rusaknya fasilitas umum khususnya sekolah dasar di beberapa daerah, termasuk Kecamatan Cugenang. Kerusakan parah pada sekolah dasar, berdampak pada terganggunya kegiatan belajar mengajar (KBM). Penelitian ini bertujuan untuk mengetahui sebaran kerusakan pada Sekolah Dasar di kecamatan Cugenang, kabupaten Cianjur dengan menggunakan metode Nearest Neighbor Analysis (NNA) serta teknik proximity dengan metode Buffer dalam Sistem Informasi Geografi (SIG). Hasilnya, dari metode NNA diperoleh Pola Acak dalam menentukan lokasi Sekolah Dasar di kecamatan Cugenang, sehingga tidak dapat memberikan pola linear saling melengkapi antar sekolah yang memberikan kemudahan akses. Metode Buffer dengan jangkauan 1 km dilakukan untuk melihat pola sebaran kerusakan sekolah dasar pada potensi pengalihan proses KBM yang rusak parah.
Point of Contact Pada Groundstroke Backhand Pada Atlet Junior
Authors: Ardianto Yovinus , Samodra Y. Touvan Juni , Rubiyatno Rubiyatno , Gustian Uray , Sastaman B Putra , Sofyan Davi 
Published: April 2023

Penelitian ini bertujuan untuk memperoleh informasi analisis secar spefisik terhadap point of contact antara bola dengan raket pada cabang olahraga Tenis lapangan. Point of contact khususnya pada teknik groundstroke backhand. Metode yang digunakan kuantitatif deskriptif, dalam penelitian ini dilakukan analisis video menggunakan software kinovea. Populasi penelitian adalah atlet atlet junior tenis lapangan di lapangan tenis Pangeran Nata Kusuma Sintang berjumlah 4 orang yang masih aktif latihan selama 1 tahun. Dilakukan perekaman vidio yang kemudian dijadikan dasar untuk analisis dengan menggunakan software kinovea. Analisis dimaksudkan fokus pada bagaian point of contact antara raket dengan bola tenis. Hasil analisis data dibandingkan dengan Novak Djokovic sebagai pembanding. Hasil penelitian menunjukkan tahap perkenaan (point of contact) terbagi atas; sudut lengan, sudut raket, dan sudut tungkai. Sudut lengan dan sudut raket memiliki nilai sudut lebih kecil dari benchmark artinya atlet mempunyai jangkauan yang pendek dan gaya impact rendah. Sedangkan sudut tungkai memiliki nilai sudut lebih besar dari benchmark dimana pada sudut tungkai yang lebih besar membuat pergerakan langkah atlet tidak maksimal. Kesimpulan dalam teknik ground stroke back hand pada khususnya kajian impact perlu untuk atlet pemula jika dibandingkan dengan atlet prefesional memiliki perbedaan bai dari posisi lengan, sudut raket dan sudut tungkai. Ketiga hal ini setidaknya menjadi perhatian dalam peningkatan kemampuan melelakukan groundstroke.
ISLAMIC INTEGRATED MATHEMATICS TEXTBOOKS FOR JUNIOR HIGHSTUDENTS
Authors: Sepriyanti Nana , Nurdin Syafruddin , Kustati Martin , Nasir Wan , Afriadi Juli , Aniswita Aniswita 
Published: May 2023

Many integrated textbooks between mathematics and another fields such as, music, culture, linguistics, etc. This study developed a valid, practical, and effective Islamic integrated mathematics textbooks for junior high/MTs students grade VII. This study is a developmental research by adopting Plomp model which consists of three phases i.e. preliminary research, prototype stage (developmental or prototyping phase), and assessment phase. The developed textbook has been validated by mathematicians, design experts, and linguists. The research data were collected using observation, interviews, questionnaires and test. Data processing in this study was carried out using quantitative decriptive and qualitative decriptive analysis. The results showed that the Islamic integrated mathematics textbooks for Junior High/MTs students is properly and well developed and applicable as the teaching materials in learning mathematics. The valid criterion is because the textbooks are developed in accordance with the principles of the scientific and logical knowledge. The practical criterion is because the textbooks are applicable in accordance with the settings that have been designed and developed. The effective criterion is because the textbooks can improve student’s mathematics ability.
EFEKTIVITAS PENERAPAN BATAS USIA PERKAWINAN MENURUT UNDANG-UNDANG PERKAWINAN NO.16 TAHUN 2019 PADA MASA PANDEMI COVID-19
Authors: Husni Syauqi Mubarok 
Published: May 2023

Penelitian ini menganalisa apakah batas usia perkawinan dalam Undang-Undang Perkawinan No. 16 Tahun 2019 telah berlaku secara efektif selama masa pandemi di Pengadilan Agama Tanjung Karang. Penelitian ini merupakan field research dengan menggunakan analisis teori efektivitas. Pengumpulan data melalui wawancara dan dokumentasi. Hasil penelitian ini menunjukkan bahwasanya penerapan UUP yang mengatur tentang batas usia pernikahan belum efektif karena beberapa faktor, di antaranya: peraturan tersebut belum ditaati oleh masyarakat Bandar Lampung secara menyeluruh, tidak adanya sanksi yang tegas bagi pelanggaran batas usia tersebut, kurangnya sosialisasi dan fasilitas pendukung sosialiasasi dari penegak hukum untuk sehingga banyak masyarakat yang belum paham tentang aturan UUP, juga kurangnya pengawasan dan pendidikan agama orangtua sehingga anak-anaknya banyak terjerumus ke dalam pergaulan bebas yang memaksa mereka harus menikah sebelum waktunya.
Pemanfaatan Media Sosial Instagram Sebagai Sarana Promosi di Dinas Perpustakaan dan Kearsipan Provinsi Sulawesi Selatan
Authors: Tasya Ana , Marni Marni , Ramadayanti Ramadayanti 
Published: May 2023

Utilization of Instagram Social Media asa Promotional Facility at the Library and Archives Office of South Sulawesi Province. The main problem raised in this study is how the form of promotion carried out by the D inas P library and K archives of South Sulawesi Province, then how to use social media Instagram as a means of promotion in Dinas Plibrary and K archives of South Sulawesi Province. This research uses a type of descriptive research with a qualitative approach. Data collection techniques used are through interviews, observation, and documentation. The sources of data in this study are librarians and followers of Instagram social media accounts in the library and archives of South Sulawesi Province, as for the technical analysis and data processing, namely data reduction, data presentation and conclusions. The results showed that the form of promotion carried out by the Library and Archives Office of South Sulawesi Province consisted of promotion in printed form and form of activities. The use of Instagram social media by the South Sulawesi Provincial Library and Archives Office is considered effective in promoting collections, services, and activities on Instagram. This can be seen on Instagram social media with the username @dispusarsipsulsel, library promotion is carried out by utilizing features on Instagram such as Feed, Reels, Highlight, Instastory, Guide, Hastag, and live broadcasts.
Abstrak
Pemanfaatan Media Sosial Instagram Sebagai Sarana Promosi di Dinas Perpustakaan dan Kearsipan Provinsi Sulawesi Selatan. Pokok masalah yang diangkat dalam penelitian ini adalah bagaimana bentuk promosi yang dilakukan oleh Dinas Perpustakaan dan Kearsipan Provinsi Sulawesi Selatan, kemudian bagaimana pemanfaatan media sosial Instagram sebagai sarana promosi di Dinas Perpustakaan dan Kearsipan Provinsi Sulawesi Selatan. Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data yang digunakan yaitu melalui wawancara, observasi, dan dokumentasi. Sumber data dalam penelitian ini yaitu pustakawan dan pengikut akun media sosial Instagram Dinas Perpustakaan dan Kearsipan Provinsi Sulawesi Selatan, adapun teknik analisis dan pengolahan data yaitu reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa bentuk promosi yang dilakukan oleh Dinas Perpustakaan dan Kearsipan Provinsi Sulawesi Selatan terdiri atas promosi dalam bentuk tercetak dan bentuk kegiatan. Pemanfaatan media sosial Instagram oleh Dinas Perpustakaan dan Kearsipan Provinsi Sulawesi Selatan dinilai sudah efektif dalam mempromosikan koleksi, layanan, dan kegiatan di Instagram. Hal ini dapat dilihat di media sosial Instagram dengan nama pengguna @dispusarsipsulsel, promosi perpustakaan dilakukan dengan memanfaatkan fitur-fitur yang ada di Instagram seperti Feed, Reels, Highlight, Instastory, Guide, Hastag, dan siaran langsung.
In vivo healing potential of Vitis Vinifera L. and Punica Granatum L. fruit extracts in excision and burn models in rabbits
Authors: Zeghad Nadia , Ejaz Ahmed , Zakryya Khan Muhammad , Aicha Madi , Abdelmalik Belkhiri 
Published: May 2023

Abstract

Aim. The present study was carried out to evaluate the wound healing potential of crude Hydroalcoholic fruit extracts of Grape (Vitis vinifera L.) and Pomegranate (Punica granatum L.) in experimental animals.

Material and methods. Extracts were formulated as ointments (250 mg), and their wound healing properties were determined by using two models: i.e. excision and burn models, in rabbits. Wound healing potential was assessed by measuring rate of wound contraction (percentage wound contraction) and the epithelialization period. Tukey test (HSD) test was used to analyze the obtained results. The value of p <0.05 was considered as a level of significance. The reference standard was wadded Cicatryl® ointment.

Results. The result showed that crude fruit extracts of Vitis vinifera L. and Punica granatum L. exhibited a significant (p <0.0001) rate of wound contraction and significant (p<0.0001) decrease in the period of epithelialization compared to the control (untreated) group in both the models studied.

Conclusion. Our results suggest that topical treatment of fruit extracts of Vitis vinifera L. and Punica granatum L. accelerate wound healing activity, thus our study supports their traditional use. Both extracts can be used as a potential source of wound healing therapeutics.
Evaluation of the toxicity and hepatoprotective properties of new s-substituted pteridins
Authors: Groma Natalya , Berest Galyna , Antypenko Oleksii , Voskoboinik Oleksii , Kopiika Vira , Kovalenko Serhii , Shvets Volodymyr 
Published: May 2023

Abstract
Liver damage is a common problem around the world, and pharmacocorrection of such disease is carried out by administration of various drugs. Natural and synthetic thio-containing compounds are important in this respect. Most of these, however, have side effects and do not always meet the criteria of evidence-based medicine. Therefore, the search for new drugs with hepatoprotective properties, characterized by high efficiency and low toxicity, is an urgent problem of current pharmacology and biochemistry. The purpose of this study was to assess the acute toxicity of new potentially bioactive S-substituted pteridinones, to select the least toxic substance, to improve the pharmaco-technological characteristics, and to study the hepatoprotective properties in an experimental model of tetrachloromethane hepatitis in rats. Herein, comparison of the hepatoprotective properties of compound 4.1 and the reference drug "Thiotriazoline" is based on biochemical studies. The research results showed that sub-stance 4.1 had a positive effect on biochemical processes by increasing the compensatory mechanisms of antioxidant systems, while reducing the infiltrative, destructive and inflamma-tory process in the liver, evoking decreases in the cytolytic process, restoring the structure of the components of the membrane of hepatocytes, stabilizing and enhancing the functional activity of the liver, restoring the liver’s protein-synthesizing function and increasing the abil-ity to restore metabolic disorders in the liver. As a result of the biochemical study of the hepa-toprotective effect of compound 4.1, it was found that the studied substance is a non-toxic compound with antioxidant properties.
Myositis-myasthenic overlap syndrome triggered by pembrolizumab in a melanoma patient: a case report and brief review of the literature
Authors: Carrolo Margarida , Machado Sara , Gomes Paulo , Chaves Andreia , Quintela António 
Published: May 2023

Background:
In the era of precision medicine, immune checkpoint inhibitors (ICIs) have dramatically changed the therapeutic approach toward advanced cancers. Despite an undeniably therapeutic benefit, ICIs have unique and uncharted toxicities known as immune-related adverse events (irAEs).

Case Presentation:
We report a rare overlap syndrome of inflammatory and necrotizing myopathy with a superimposed myasthenia-like syndrome in a melanoma patient who had received the first dose of pembrolizumab 22 days before symptoms onset. The patient initially presented with muscle weakness and ptosis and rapidly progressed to tetraparesis, extrinsic ophthalmoplegia, dysarthria, dysphagia, and respiratory difficulty with a short-term need for non-invasive ventilation and nasogastric intubation. Transitory myocarditis was also diagnosed. One month after hospital discharge, the patient still exhibits mild dysarthria, dysphagia, and ptosis and needs walking assistance.

Conclusion:
Although rare, neuromuscular irAEs impose a notable burden on morbidity and even mortality. Early recognition of symptoms and prompt intervention are crucial for the management of immunotherapy-related toxicity.
Possible Worlds of Everyday Aesthetics: The Experiencing Self, Intersubjectivity and Life-World
Authors: Eugen Ratiu Dan 
Published: April 2023

This paper investigates the relationship between the subjective-private and intersubjective-public dimensions of the aesthetic experience in everyday life. I claim that our everyday aesthetic life cannot be conceived of as a mere private world in absolute discontinuity to the public world, such as the “artworld” or the “life-world”, since it includes both personal and intersubjective dimensions. Likewise, although the “everyday” should not be thought of as absolutely one and the same for all, it is possible to search for the common features that emerge from the background of its multiple particularities. The intersubjective engagement is an essential element when analyzing the subject experiencing the everyday aesthetically, so we should acknowledge as well the intersubjective nature of a subject’s self-constitution and experience. Against the idea of the overall discontinuous nature of one’s aesthetic experience, in everyday context vs. artworld contexts, it is therefore important to consider everyday aesthetic experience as being both distinct and integrated into the continuous flux of one’s experiences, as well as related to one’s whole life. These claims will be supported by some insights on the experiencing self, supported by practical philosophy (Gadamer), as well as the characteristics of everyday life and life-world highlighted by phenomenology (Husserl, Simmel, Schutz). All these accounts offer powerful lines of argument in defending a consistent conception of the whole experiencing self and the structure of one’s everyday aesthetic life as well as its intersubjective dimension.

Article received: April 28, 2020; Article accepted: June 23, 2020; Published online: September 15, 2020; Original scholarly paper