bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial-temporal evolution of water resources utilization efficiency in Jiangsu Province
Authors: Deng Menghua , Zhang Tianshu 
Published: May 2023

Abstract
Improving water resource utilization efficiency is essential in alleviating the crisis of water resource shortage and promoting the sustainable development of the social economy. Based on the data envelopment analysis (DEA) and Malmquist index, the agricultural, industrial, and domestic water resource utilization efficiency of Jiangsu Province from 2011 to 2020 are evaluated, respectively. The results show that the DEA efficiency of agriculture and industrial water use is greater than that of domestic while the improvement of agricultural and domestic water efficiency is larger than that of industrial. Temporally, the water use efficiency was on an increasing trend from 2011 to 2020, and technological progress is the main factor in improving the water resource utilization efficiency. Spatially, the water use efficiency of southern cities in Jiangsu Province is higher than that of northern and central cities, but the difference between cities is gradually narrowing. To improve the efficiency of water resource efficiency, the government should formulate water resource management policies according to local conditions.
Utilizing CaCl2 to promote the enrichment and bioavailability of phosphorus in incinerated sludge ash
Authors: Yu Rongzhen , Xiao Ya , Zhao Xiaojiao , Yao Pin , Yan Tinggui 
Published: May 2023

Abstract

Recovering phosphorus from incineration sludge sewage ash (ISSA) is a well-established technology, with a greater recovery potential than that of supernatant or sludge. ISSA can be utilized as a secondary raw material in the fertilizer industry, or as a fertilizer if heavy metal concentrations do not exceed permissible limits, thus reducing the cost of phosphorus recovery. Increasing the temperature to produce ISSA with higher solubility and plant availability of phosphorus is advantageous for both pathways. But a decrease in the extraction of phosphorus is also observed at high temperatures, thereby diminishing the overall economic benefits. In this study, CaCl2 was utilized to mitigate the decrease in the extraction rate and also to promote the bioavailability of phosphorus. The addition of CaCl2 (80 g/kg of dry sludge) effectively promoted the conversion of non-apatite inorganic phosphorus to apatite inorganic phosphorus at a rate of 87.73% at 750 °C. Furthermore, the decrease in the extraction rate of phosphorus at 1,050 °C was comparatively smaller in the presence of CaCl2. If iron flocculants are used to capture P in wastewater management, it may be necessary to pay special attention to the amount of addition and incineration temperature to maximize the economic potential of recycling.
Green synthesis of CuO nanoparticles using Hibiscus sabdariffa L. extract to treat wastewater in Soba Sewage Treatment Plant, Sudan
Authors: Almisbah Samaher R. E. , Mohammed Abdelhafeez M. A. , Elgamouz Abdelaziz , Bihi Alaa , Kawde Abdelnasser 
Published: May 2023

Abstract

Looking for a cost-effective and ecofriendly method for wastewater treatment is a global challenge. Therefore, this study investigated the removal of wastewater pollutants using copper oxide nanoparticles (CuONPs). CuONPs synthesized by a green solution combustion synthesis (SCS) and characterized by ultraviolet–visible spectroscopy (UV–Vis), Fourier transform infrared (FT-IR), powder X-ray diffraction analysis (PXRD), and scanning electron microscopy (SEM) techniques. PXRD showed nanoparticle sizes ranging from 10 to 20 polycrystalline patterns indexed with two peaks corresponding to (111) and (113) reflections of the face-centered cubic CuO crystal. The energy-dispersive spectroscopy analysis obtained in conjunction with SEM analysis proved the presence of Cu and O atoms at 86.3 and 13.6%, respectively, confirming the reduction and capping of Cu with Hibiscus sabdariffa extract's phytochemicals. The CuONPs proved to be a promising decontaminant for wastewater found to reduce biochemical oxygen demand (BOD) and chemical oxygen demand (COD) by 56%, and very efficient in reducing both the total dissolved matter (TDS) and conductivity (σ) by 99%. The CuONPs removed simultaneously chromium, copper, and chloride with respective percentages of 26, 78.8, and 78.2%. Green synthesis of nanoparticles is a simple, rapid, cost-effective, and ecofriendly method that successfully removed contaminants from wastewater.
Examining the Extension of the Technology Acceptance Model (TAM) in
Electronic Medical Records Among Community Pharmacists in Malaysia
Authors: Iskandar Yulita Hanum P. , Tangiisuran Balamurugan , Mohamed Ariff Adilah 
Published: May 2023

Background:
Background: Electronic medical records (EMR) have been proven to reduce medical errors in drug distribution. However, EMR adoption is still relatively low among Malaysian community pharmacists.

Objective:
As a result, this study aims to see how community pharmacists in Malaysia use the EMR system. The factors influencing the community pharmacist's intent in adopting EMR will also be determined.

Methods:
The Technology Acceptance Model (TAM) and Extended TAM were utilized in this study to determine Malaysian community pharmacists' main intention for using EMR. The information was gathered by surveying 144 community pharmacists nationwide. The data was analyzed using SPSS and Smart PLS software.

Results:
The study found a positively significant relationship between Perceived Usefulness (PU) and Behavioural Intention to Use (BIU).

Conclusion:
This study shows critical factors influencing the intention to use EMR among Malaysian community pharmacists. Hopefully, this study will better understand the importance of EMR in the healthcare industry.
The Era of Plant Breeding: Conventional Breeding to Genomics-assisted
Breeding for Crop Improvement
Authors: Krishna Thumadath Palayullaparambil Ajeesh , Veeramuthu Duraipandiyan , Maharajan Theivanayagam , Soosaimanickam Mariapackiam 
Published: May 2023

Abstract:
Plant breeding has made a significant contribution to increasing agricultural production.
Conventional breeding based on phenotypic selection is not effective for crop improvement. Because
phenotype is considerably influenced by environmental factors, which will affect the selection of
breeding materials for crop improvement. The past two decades have seen tremendous progress in
plant breeding research. Especially the availability of high-throughput molecular markers followed by
genomic-assisted approaches significantly contributed to advancing plant breeding. Integration of
speed breeding with genomic and phenomic facilities allowed rapid quantitative trait loci (QTL)/gene
identifications and ultimately accelerated crop improvement programs. The advances in sequencing
technology helps to understand the genome organization of many crops and helped with genomic selection
in crop breeding. Plant breeding has gradually changed from phenotype-to-genotype-based to
genotype-to-phenotype-based selection. High-throughput phenomic platforms have played a significant
role in the modern breeding program and are considered an essential part of precision breeding.
In this review, we discuss the rapid advance in plant breeding technology for efficient crop improvements
and provide details on various approaches/platforms that are helpful for crop improvement. This
review will help researchers understand the recent developments in crop breeding and improvements.
Immunotherapy in Combination with Chemotherapy for Triple-negative
Breast Cancer
Authors: Elizabeth Melendez Solano , Cristina Stevens Barrón Jazmín , Christian Chapa González 
Published: May 2023

Abstract:
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks
estrogen and progesterone receptors and does not overexpress the human epidermal growth factor receptor
2 (HER2). Previous treatment options for TNBC were limited to chemotherapy alone, resulting
in a poor patient prognosis. In 2018, an estimated 2.1 million new cases of breast cancer were diagnosed
globally, with the incidence increasing by 0.5% annually from 2014 to 2018. The exact prevalence
of TNBC is difficult to determine because it is based on the absence of certain receptors and
overexpression of HER2. Treatment options for TNBC include surgery, chemotherapy, radiation therapy,
and targeted therapy. The available evidence suggests that combination immunotherapy using
PD-1/PD-L1 inhibitors may be a promising treatment option for metastatic TNBC. In this review, we
evaluated the efficacy and safety of different immunotherapies regimens for the treatment of TNBC.
In many clinical trials, the overall response rate and survival were better in patients treated with these
drug combinations than those treated with chemotherapy alone. Although definitive treatments are not
within reach, efforts to gain a deeper understanding of combination immunotherapy have the potential
to overcome the urge for safe and effective treatments.
The Effect of Kegel Exercises and Pelvic Floor Physiotherapy on the
Improvements of Stress Urinary Incontinence and Urge Incontinence in
Women with Normal Vaginal Delivery
Authors: Nahid Radnia , Mahsa Bakhtiari , Alimohammadi Neda , Samar Moghadami 
Published: May 2023

Objectives:
Pregnancy and normal vaginal delivery, are the main risk factors for urinary
incontinence in women. A variety of treatments such as bladder training and pelvic floor exercises are
effective for urinary incontinence. This interventional study has been conducted to compare the
influence of Kegel exercises and pelvic floor physiotherapy on the improvements of urge and stress
incontinence in women with first or second singleton pregnancies who have experienced normal
vaginal delivery.

Methods:
One hundred fifty women with urinary incontinence in the postpartum period, who were
divided randomly into 3 groups of 50 patients, participated in this prospective interventional study.
The women were primigravida or it was their second labor. None of them complained of urinary
incontinence before pregnancy. All of them had a normal vaginal delivery. The first group included
females who were asked to perform Kegel exercises. The second group had 8 weekly physiotherapy
appointments. The control group, included mothers who received routine care. We compared the
prevalence of urge and stress incontinence between groups.

Results:
We found that the relative risk of urge and stress incontinence among mothers in the control
group was more than in the intervention groups, but this difference was only statistically significant in
the subject of stress incontinence between the Kegel and control groups. The reduction of urge incontinence
prevalence among mothers in the Kegel and physiotherapy groups, was more than control
group, although this reduction was not significant.

Conclusion:
There is a significant decrease in the prevalence of stress urinary incontinence at the end
of the 8th and 12th weeks postpartum compared to the control group. Although the prevalence of urge
incontinence among women in intervention groups was lower than in the control group, it was not
significant. It seems the effect of Kegel exercises and pelvic floor physiotherapy, in reducing stress
incontinence at the end of the 8th week, is almost equal.
Isoscutellarein from Bixa orellana Leaves Uncompetitively Inhibits Recombinant
Human Aldose Reductase and Prevents Sorbitol Accumulation
and Lens Opacity
Authors: Durgam Mohan Krishna , Bodiga Vijaya Lakshmi , Vemuri Praveen Kumar , Bodiga Sreedhar 
Published: May 2023

Introduction:
Enhanced aldose reductase activity results in increased accumulation of sorbitol.
Therefore, inhibition of aldose reductase is an effective strategy to prevent or delay certain diabetic
complications.

Methods:
Various extracts of the leaves of B. orellana were tested for their inhibitory activity on the
aldose reductase. Ethyl acetate extract that showed maximum inhibition was further fractionated and the
inhibitor was identified as isoscutellarein by spectroscopic methods. IC50 of recombinant human aldose
reductase by isoscutellarein was found to be 14 μM and the mode of inhibition was uncompetitive with
a decrease in both Km and Vmax. Isoscutellarein was bound to the active site of aldose reductase (3RX3),
namely to Ala-299, Leu-300, Leu-301, His-110 and Tyr-48.

Results:
Docking results exhibited a binding energy of -9.15 kJ/mol.

Conclusion:
The incubation of red blood cells with high glucose concentrations mimicking hyperglycemic
conditions promoted sorbitol accumulation, which was effectively inhibited by isoscutellarein.
Further, xylose-induced opacity of the lens was effectively inhibited by isoscutellarein.
Imaging Techniques for Assessment of Cranio-maxillofacial Complications of Covid-19, A Systematic Review
Authors: Abu-Hammad Osama , Zain-Alabedeen Ebtihal , Althagafi Nebras , Eshky Rawah , Abdouh Ismail , Jambi Safa , Ayed Yosra , Dar-Odeh Najla 
Published: May 2023

Objectives:
The aim of this review was to summarize and describe the reported imaging techniques used for COVID-19 patients who have developed cranio-maxillofacial complications.

Methods:
A systematic review of the literature was conducted using MEDLINE/PubMed, Google Scholar, and Scopus databases. Included articles were case reports/series, clinical trials and cross-sectional studies on adult COVID-19 patients that were written in English. Excluded articles were those discussing the radiological assessment of COVID-19 complications manifested in the oral mucosa or the extra-maxillofacial areas. Combinations of the following keywords were used: “COVID-19”, “Maxillofacial,” “complications,” “imaging,” “radiological,” “Mandible,” “Jaw,” “Osteonecrosis,” “cavernous sinus thrombosis,” and “mucormycosis.”

Results:
A total of 13 articles were included. Imaging techniques used were: magnetic resonance imaging (MRI), computerized tomography (CT), multislice CT (MSCT), contrast-enhanced MRI, contrast-enhanced CT, and cone beam CT. These imaging techniques were used in the diagnosis of craniomaxillofacial complications of COVID-19, including sinusitis, cavernous sinus thrombosis, jaw osteomyelitis, cellulitis, vision loss, and mucormycosis. CT and its variants were the most commonly used techniques.

Conclusion:
Within the limitations of the included studies, which were mainly case reports, it can be concluded that imaging techniques that were employed in the diagnosis of craniomaxillofacial complications of COVID-19 were limited to MRI, CT and their variants. Despite the efficiency of the utilized imaging techniques, clinicians worldwide should be aware of the most effective and least risk-associated methods used in such circumstances.
Clinical and Radiological Benefits of Hyaluronic Acid in Periodontal Infrabony Defects: A Systematic Review and Meta-analysis
Authors: Aldahlawi Salwa A. 
Published: May 2023

Purpose:
There is no consensus on the clinical and radiological benefits of hyaluronic acid (HA) in patients with periodontitis having infrabony defects. Hence, this study examined the effects of HA in periodontitis patients with infrabony defects through a comprehensive systematic review process.

Methodology:
A systematic literature search was performed using PubMed/Medline, Scopus, Embase and Cochrane Library from inception to March 2022. Randomized or non-randomized clinical trials and single-arm clinical trials that assessed the clinical and radiological benefits of HA in periodontitis patients with infrabony defects with a minimum of 6 months follow-up were included in this study. Surgical regenerative therapy was considered as the comparator. The Cochrane risk of bias assessment tool and Downs and Black checklist was used for the quality assessment of randomized and non-randomized interventional studies, respectively. A subgroup and sensitivity analyses were performed to explore the heterogeneity and robustness of the findings, respectively.

Results:
A total of 13 out of 725 studies were included in this systematic review, of which 9 were considered for meta-analysis. The meta-analysis indicated significant benefits of HA in terms of reduction in probing pocket depth (SMD: 1.12mm; 95%CI: 0.60-1.65; 9 studies), bone defect depth (SMD: 1.04mm; 95%CI: 0.62-1.47; 3 studies) and gain in clinical attachment level (SMD: 1.40 mm; 95%CI: 0.33-2.47; 8 studies). Overall, the quality of included studies was good.

Conclusion:
The current evidence indicates that the administration of HA in the periodontal regenerative treatment of infrabony defects was significantly effective in increasing clinical attachment levels and reducing probing pocket and bone defect depth.
Evaluation of Knowledge, Awareness, Preparedness, and Measures among Dental Technicians Attending Covid-19 in Jordan
Authors: Bakri Isra Abdulkarim AL , Khader Yousef , Al Hourani Zeid Ahmad , Alshatrat Sabha Mahmoud 
Published: May 2023

Introduction:
During the pandemic of COVID-19, Jordan imposed strict measures and abandoned selected medical procedures. Due to the high risk of cross-infection among dental team members, dental clinics and laboratories were subjected to definite regulations before being allowed back to work.

Aims:
This survey aims to assess the knowledge, awareness and preparedness of dental technicians in Jordan regarding COVID-19. Also, to investigate prevention measures for dental technicians working during the COVID-19 pandemic.

Methods:
A cross-sectional self-administered online survey was distributed electronically as a Google form via social media platforms. The study population consisted of registered dental technicians working in public and private laboratories in Jordan. The questionnaire consisted of a series of questions; demographic characteristics; knowledge and awareness about COVID-19, and the preparedness and measures to practice dental laboratory procedures during the pandemic.

Results:
This study included a total of 90 dental technicians [ 31 females and 59 males]; their ages ranged from 22-60 years old. Almost all the participants [ 90%] were found knowledgeable about COVID-19. Governmental organizations, and visual and social media were the main sources of information. The majority of participants [ >85%] encouraged drifting to digital dental technology protocols during COVID-19 pandemic. More than 65% of the participants reported COVID-19 very dangerous and considered themselves in a high risk of COVID-19 transmission.

Conclusion:
Most dental technicians have sufficient knowledge about COVID-19. However, most of them are not prepared to deal with impressions, restorations, and dentures of infected/suspected cases. Educational and training programs regarding COVID-19 among dental technicians are significantly needed.
The Extent of Delay in Diagnosis, Treatment and their Associated
Factors among Tuberculosis Patients Attending Government
Hospitals of Rishikesh, Uttarakhand: A Cross-Sectional Study
Authors: Supehia Sakshi , Singh Mahendra , Bahurupi Yogesh , Aggarwal Pradeep , Chandra Rishita , Sharma Nandita 
Published: May 2023

Abstract:
“Tuberculosis (TB) remains a major public health problem” worldwide, affecting almost
all age groups. “Early diagnosis and prompt treatment are essential to significantly reducing the TB
burden.” However, a significant proportion of cases remain undiagnosed and untreated, which
plays a vital role in the transmission of the disease and severity of the illness in the community in
most developing countries.

Aim & Objectives:
This study aimed to assess “the extent of delay in diagnosis and treatment of
TB patients” and to identify the major factors associated with such delays (whether patient or
health system-related) among TB patients in Rishikesh.

Methods:
This descriptive cross-sectional study was conducted in Rishikesh Town, Dehradun District,
Uttara khand, India. Total of 130 newly diagnosed TB patients were recruited as study participants who
attended the government hospitals of Rishikesh, All India Institute of Medical Sciences, Rishikesh and S
P S Government Hospital, Rishikesh. A universal sampling technique was used in this study.

Results:
The mean age of the study participant was 36.75 [Standard Deviation (SD), 17.6], and the
median age was 34 years. Of the patients, 64.6% were men, and 35.4% were women. The extent of
various delays, such as patient delay (median 16 days), diagnostic delay (median 78.5 days), treatment
delay (median 4 days), health system delay (43 days), and total delay (median 81 days).

Conclusion:
The misconception of any chronic disease may lead to a false diagnosis or long treatment
for symptomatic relief; the absence of proper diagnostic tests and doctor shopping could be
the reasons for the prolonged diagnostic delay. Therefore, by strengthening the collaboration between
private and public practitioners in order to meet the expectations of the Government of India
to achieve the goals of the “National Strategic Plan for ending TB” in India by providing good
quality care for all patients.
Avances sobre la institucionalización en las Primeras Letras en el Valle de Uco (Mendoza, Argentina) entre 1771 y 1872
Authors: Elgueta Victor Martín 
Published: May 2023

Esta tesis de doctorado es un estudio sobre la institucionalización de la instrucción en las Primeras Letras en el Valle de Uco (Mendoza, Argentina) entre 1771 y 1872. En esta región, la Enseñanza de Primeras Letras, formó parte de la instrucción militar, primero; y de las regulaciones policiales, después. Instrucción militar que tenía como forma de organización escuelas. Formas organizativas que devinieron luego como establecimientos educativos diferenciados de acuerdo a la siguiente genealogía: Escuelas del Rey (1771-1810), Escuelas de la Patria (1810-1820) y Escuelas de Primeras Letras (1820-1872).
La diferenciación de establecimientos educativos de primeras letras se consolidó en Mendoza con la sanción de la obligatoriedad de las Escuelas Fiscales (1872-1884) y la creación del órgano específico de regulación: Superintendencia General de Escuelas. Con ello los enseñantes dejaron de ser denominados con el término castrense de “preceptores” para pasar a ser denominados como “maestros” en un contexto de abandono del método lancasteriano e implementación del sistema graduado.
Con la sanción de la Ley 1420 en 1884 los establecimientos educativos de la provincia de Mendoza pasaron a denominarse Escuelas Fiscales Primarias. Marco jurídico que provocó un solapamiento de las experiencias educativas precedentes afianzado con el uso de un discurso fundacional de la propuesta de escolarización sarmientina. Aspecto que se complejizó con la sanción de la Ley Laínez de 1905, momento a partir del cual los establecimientos educativos adoptaron la denominación de Escuelas Primarias y se produjo una cohabitación de establecimientos dependientes de la provincia y dependientes del Estado Nacional hasta 1979.