bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical primary central nervous system lymphoma and glioblastoma: multiparametric differentiation based on non-enhancing volume, apparent diffusion coefficient, and arterial spin labeling
Authors: Yu Xiaojun , Hong Weiping , Ye Minting , Lai Mingyao , Shi Changzheng , Li Linzhen , Ye Kunlin , Xu Jiali , Ai Ruyu , Shan Changguo , Cai Linbo , Luo Liangping 
Published: May 2023

Abstract
Objectives
To evaluate the multiparametric diagnostic performance with non-enhancing tumor volume, apparent diffusion coefficient (ADC), and arterial spin labeling (ASL) to differentiate between atypical primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM).

Methods
One hundred and fifty-eight patients with pathologically confirmed typical PCNSL (n = 59), atypical PCNSL (hemorrhage, necrosis, or heterogeneous contrast enhancement, n = 29), and GBM (n = 70) were selected. Relative minimum ADC (rADCmin), mean (rADCmean), maximum (rADCmax), and rADCmax-min (rADCdif) were obtained by standardization of the contralateral white matter. Maximum cerebral blood flow (CBFmax) was obtained according to the ASL-CBF map. The regions of interests (ROIs) were manually delineated on the inner side of the tumor to further generate a 3D-ROI and obtain the non-enhancing tumor (nET) volume. The area under the curve (AUC) was used to evaluate the diagnostic performance.

Results
Atypical PCNSLs showed significantly lower rADCmax, rADCmean, and rADCdif than that of GBMs. GBMs showed significantly higher CBFmax and nET volume ratios than that of atypical PCNSLs. Combined three-variable models with rADCmean, CBFmax, and nET volume ratio were superior to one- and two-variable models. The AUC of the three-variable model was 0.96, and the sensitivity and specificity were 90% and 96.55%, respectively.

Conclusion
The combined evaluation of rADCmean, CBFmax, and nET volume allowed for reliable differentiation between atypical PCNSL and GBM.

Key Points
• Atypical PCNSL is easily misdiagnosed as glioblastoma, which leads to unnecessary surgical resection.
• The nET volume, ADC, and ASL-derived parameter (CBF) were lower for atypical PCNSL than that for glioblastoma.
• The combination of multiple parameters performed well (AUC = 0.96) in the discrimination between atypical PCNSL and glioblastoma.
A Patch in Time Saves Nine: Methods for the Identification of Localised Dynamical Behaviour and Lifespans of Coherent Structures
Authors: Blachut Chantelle , González-Tokman Cecilia , Hernández-Dueñas Gerardo 
Published: May 2023

AbstractWe develop a transfer operator-based method for the detection of coherent structures and their associated lifespans. Characterising the lifespan of coherent structures allows us to identify dynamically meaningful time windows, which may be associated with transient coherent structures in the localised phase space, as well as with time intervals within which these structures experience fundamental changes, such as merging or separation events. The localised transfer operator approach we pursue allows one to explore the fundamental properties of a dynamical system without full knowledge of the dynamics. The algorithms we develop prove useful not only in the simple case of a periodically driven double well potential model, but also in more complex cases generated using the rotating Boussinesq equations.
Spectral investigation of soot absorption properties during laser-induced incandescence measurements
Authors: Migliorini Francesca , Dondè Roberto , De Iuliis Silvana 
Published: May 2023

AbstractThe effect of rapid laser irradiation on the optical properties of mature soot particles is investigated by performing wavelength-resolved extinction measurements in the visible spectral region. In particular, the spectral behavior of the absorption properties is explored during laser irradiation, at the peak of the incandescence signal (prompt LII) and few nanoseconds after the peak, and finally when particles have reached an equilibrium condition with the surrounding gas. A significant variation of the absorption coefficient of the laser-irradiated soot particles compared to that of the pristine ones is observed already at the LII peak. Such variation keeps evolving with time until it reaches a final permanent value. Results are presented in relation to the laser fluence used for irradiation and discussed with the aim of stressing the need of knowing the entity of the modification of soot absorption properties during laser irradiation for a correct interpretation of LII data.
Fatiguing freestyle swimming modifies miRNA profiles of circulating extracellular vesicles in athletes
Authors: Lai Zhijie , Lin Wentao , Yan Xu , Chen Xiaobin , Xu Guoqin 
Published: May 2023

AbstractExtracellular vesicles (EVs) are secreted by various tissues and cells under normal physiological or pathological conditions. Exercise-induced EVs may be involved in the adaptation of exercise-induced fatigue. The 1500-m freestyle is the longest pool-based swimming event in the Olympic Games, and there is a paucity of information regarding changes in the miRNA profiles of circulating EVs after a single session of fatiguing swimming. In this study, 13 male freestyle swimmers conducted a fatiguing 1500-m freestyle swimming session at the speed of their best previously recorded swimming performance. Fasting venous blood was collected before and after the swimming session for analysis. 70 miRNAs from the circulating EVs were found to be differentially expressed after the fatiguing 1500-m freestyle swimming session, among which 45 and 25 miRNAs were up-regulated and down-regulated, respectively. As for the target genes of five miRNAs (miR-144-3p, miR-145-3p, miR-509-5p, miR-891b, and miR-890) with the largest expression-fold variation, their functional enrichment analysis demonstrated that the target genes were involved in the regulation of long-term potentiation (LTP), vascular endothelial growth factor (VEGF), glutathione metabolism pathway, dopaminergic synapse, signal transmission, and other biological processes. In summary, these findings reveal that a single session of fatiguing swimming modifies the miRNAs profiles of the circulating EVs, especially miR-144-3p, miR-145-3p, miR-509-5p, miR-891b, and miR-890, which clarifies new mechanisms for the adaptation to a single session of fatiguing exercise from the perspective of EV-miRNAs.
Mid-term outcomes after single anastomosis sleeve ileal (SASI) bypass in treatment of morbid obesity
Authors: Aghajani Ebrahim , Schou Carl , Gislason Hjortur , Nergaard Bent Johnny 
Published: May 2023

Abstract
Background
According to several short-term studies, single-anastomosis sleeve ileal (SASI) bypass offers similar weight loss to Roux-en-Y Gastric Bypass (RYGB) with fewer complication and better comorbidity reduction/resolution. Long-term data on this operation is lacking in the literature. The purpose of this study was to analyze the outcomes of SASI bypass up to 4 years.

Methods
This study is a retrospective cohort analysis of 366 patients with morbid obesity who underwent primary SASI bypass from January 2018 to February 2022.

Results
The mean age and preoperative body mass index (BMI) were 41 years (range 22–71 years) and 43.9 ± 6.5 kg/m2, respectively. Follow-up was available for 229 patients at 1-year (89%), 112 patients at 2-year (75%), 61 patients at 3-year (75%), and 35 patients at 4-year (71%). The intraoperative, short-term, and long-term complication rates were 0%, 2.5%, 4.6%, respectively. After 4 years, mean percentage excess weight loss (%EWL) was 93.3% and total weight loss (%TWL) was 41.2%. Remission of comorbidities was 93% for type 2 diabetes mellitus, 73% for hypertension, 83% for hyperlipidemia, 79% for sleep apnea, and 25% for gastroesophageal reflux disease (GERD). Biliary gastritis and ulcers are seldom. Eight patients developed de novo GERD symptoms requiring proton pump inhibitor treatment. None of the patients in our study had hypoalbuminemia or malabsorption that did not respond to increased protein intake and vitamin or mineral supplementation.

Conclusion
SASI bypass appears to be safe, and one of the most effective bariatric procedures regarding weight loss and obesity related comorbidities. The double-outlet created in this procedure seemingly minimizes nutritional complications.

Graphical abstract
P19-derived neuronal cells express H1, H2, and H3 histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents
Authors: Perez Mariela Gomez , Tanasie Georgiana , Neree Armelle Tchoumi , Suarez Narjara Gonzalez , Lafortune Clara , Paquin Joanne , Marcocci Lucia , Pietrangeli Paola , Annabi Borhane , Mateescu Mircea Alexandru 
Published: May 2023

AbstractHistamine is a biogenic amine implicated in various biological and pathological processes. Convenient cellular models are needed to screen and develop new antihistamine agents. This report aimed to characterize the response of neurons differentiated from mouse P19 embryonal carcinoma cells to histamine treatment, and to investigate the modulation of this response by antihistamine drugs, vegetal diamine oxidase, and catalase. The exposure of P19 neurons to histamine reduced cell viability to 65% maximally. This effect involves specific histamine receptors, since it was prevented by treatment with desloratadine and cimetidine, respectively, H1 and H2 antagonists, but not by the H3 antagonist ciproxifan. RT-PCR analysis showed that P19 neurons express H1 and H2 receptors, and the H3 receptor, although it seemed not involved in the histamine effect on these cells. The H4 receptor was not expressed. H1 and H2 antagonists as well as vegetal diamine oxidase diminished the intracellular Ca2+ mobilization triggered by histamine. The treatment with vegetal diamine oxidase or catalase protected against mortality and a significant reduction of H2O2 level, generated from the cells under the histamine action, was found upon treatments with desloratadine, cimetidine, vegetal diamine oxidase, or catalase. Overall, the results indicate the expression of functional histamine receptors and open the possibility of using P19 neurons as model system to study the roles of histamine and related drugs in neuronal pathogenesis. This model is less expensive to operate and can be easily implemented by current laboratories of analysis and by Contract Research Organizations.
A critical review of environmental factors influencing the transport dynamics of microplastics in riverine systems: implications for ecological studies
Authors: Owowenu Enahoro Kennedy , Nnadozie Chika Felicitas , Akamagwuna Frank , Noundou Xavier Siwe , Uku Jude Edafe , Odume Oghenekaro Nelson 
Published: May 2023

AbstractMicroplastics (MPs) in rivers present an ecological risk. In this paper, we review hydro-geomorphological, biological, and allochthonous factors that may influence the distribution and transport of MPs in riverine systems. We also review MPs characteristics that may impact their distribution and transport. At the reach scale, hydraulic biotopes and their key features such as flow velocity, bed roughness, depth, and channel morphology are important features that shape the distribution and transport of MPs in riverine systems and should be considered in the design of MPs studies. Microbial-MPs interaction may impact MPs density, aggregation and thus transport dynamics. Instream vegetation may act as a physical trap of MPs, which may impact their horizontal transport and aggregation. Lateral transport of MPs is impacted mostly by precipitation, run-off, point and non-point discharges. The polymer density, size and shapes of MPs are critical factors that influence their transport dynamics in riverine systems. Microplastic sampling protocols should be designed to reflect hydro-geomorphological considerations. The unique interaction of MPs physical characteristics and hydraulic biotopes creates differential exposure of riverine organisms to MPs and should be used to unravel potential impacts. Biomonitoring studies should integrate the complex MPs-hydraulic interaction for ecologically meaningful investigation into organismal exposure to MPs in their preferred biotopes. Overall, our review indicates the influences of hydro-geomorphological features on the transport dynamics of MPs and their ecological significance for the study of MPs in rivers.
Truth is One (No Need for Pluralism)
Authors: Volpe Giorgio 
Published: May 2023

Abstract
In this paper, I discuss the currently most popular argument for alethic pluralism, maintaining that the so-called scope problem provides no compelling reason for abandoning the traditional view that truth is one and the same (substantive) property across the various regions of thought or discourse in which it is ascribed or denied to the things we think or say. I disarm the argument by showing that the scope problem does not arise for a number of non-deflationary, monistic views of truth that meet certain semantic and metaphysical constraints, for one can accept any of these views and provide a plausible account of the fact that mental and linguistic tokenings belonging to different regions of discourse involve radically different ways of engaging with reality ? from detecting pre-existing facts to constituting them.
Neuroimmunomodulatory properties of polysialic acid
Authors: Gretenkort Lina , Thiesler Hauke , Hildebrandt Herbert 
Published: May 2023

AbstractPolymeric sialic acid (polysialic acid, polySia) is a remarkable posttranslational modification of only few select proteins. The major, and most prominent polySia protein carrier is the neural cell adhesion molecule NCAM. Here, the key functions of polySia are to regulate interactions of NCAM and to balance cellular interactions in brain development and plasticity. During recent years, however, increasing evidence points towards a role of polySia in the modulation of immune responses. These immunomodulatory functions can be mediated by polySia on proteins other than NCAM, presented either on the cell surface or released into the extracellular space. This perspective review summarizes our current knowledge and addresses major open questions on polySia and polySia receptors in modulating innate immune responses in the brain.
Who benefits from the international classroom? A longitudinal examination of multicultural personality development during one year of international higher education
Authors: Hofhuis Joep , Jongerling Joran , Jansz Jeroen 
Published: May 2023

Abstract
Enhancing students’ intercultural competences through international higher education requires a thorough understanding of the way in which these competences develop over time, how they relate to outcomes, and which factors predict their growth. To answer these questions, a three-wave longitudinal study was conducted among a sample of first-year students in an international university program (n = 425). Intercultural competences were operationalized through the five dimensions of the Multicultural Personality Questionnaire (MPQ): Cultural Empathy, Openmindedness, Flexibility, Social Initiative and Emotional Stability. We examined development of these traits across one year, as well as their relationship with stress, life satisfaction, and academic performance (GPA). Cultural background (local vs. international student) and prior international experience (yes/no) were included as predictors. Results show that MPQ scores at the beginning of the year negatively relate to change across semester 1, which in turn is negatively related to change across semester 2. These findings suggest the presence of ceiling effects in MPQ development. In semester 1, emotional stability acts as a buffer against stress. In semester 2, stress is lower among students with higher scores on cultural empathy, and lower scores on flexibility. Cultural empathy and social initiative relate positively to academic performance. No significant main effects were found for cultural background, or prior international experience. However, these predictors interact on openmindedness and social initiative: local students with no prior international experience show a significant increase in these dimensions across the first semester, whereas the others do not.
Effects of incomplete sampling on macroinvertebrate secondary production estimates in a forested headwater stream
Authors: Pasqualini Julia , Majdi Nabil , Brauns Mario 
Published: May 2023

AbstractEstimates of secondary production depend on the efficiency of sampling methods in capturing abundances and body lengths of the entire macroinvertebrate community. The efficiency of common sampling methods in fulfilling these criteria is poorly understood. We compared the effects of a Surber sampler (250 µm mesh size) and a Freeze corer in capturing abundance, biomass, and secondary production of macroinvertebrates in a forested headwater stream. We then examined how the use of nets with different mesh sizes could affect estimates of secondary production. Macroinvertebrate abundance was three times lower, and biomass was three times higher with the Surber than with the Freeze corer. Neither method captured the entire length distribution, and incomplete sampling of body lengths and abundance resulted in underestimating total secondary production by 48% (Surber) and 49% (Freeze corer). We estimated that reducing the mesh size from 250 to 100 µm would reduce the underestimation of production from ~ 48 to ~ 12% due to the inclusion of smaller individuals. Our results improve the efficiency of common sampling methods, allowing a reliable quantification of the role of macroinvertebrates in stream ecosystem functioning.
The SDGs and fossil fuel subsidy reform
Authors: van Asselt Harro 
Published: May 2023

AbstractThis short perspective asks what is the role—and added value—of the Sustainable Development Goals (SDGs) and their associated institutional structures in the international governance of fossil fuel subsidies and their reform? It argues that whilst some progress has been made, notably through developing a methodology to define and measure fossil fuel subsidies, countries have only to a very limited extent followed up through indicator reporting and through their Voluntary National Reviews. Nevertheless, the SDGs can help highlight the various sustainable development dimensions of fossil fuel subsidies and support ongoing efforts to strengthen transparency, thereby indirectly helping to drive reform at the national level.
The biostimulant effect of an extract from Durvillaea potatorum and Ascophyllum nodosum is associated with the priming of reactive oxygen species in strawberry in south-eastern Australia
Authors: Mattner Scott W. , Villalta Oscar N. , McFarlane Dylan J. , Islam Md Tohidul , Arioli Tony , Cahill David M. 
Published: May 2023

AbstractStrawberry is an important
horticultural crop in Victoria, Australia. Grey mould caused by Botrytis cinerea reduces marketable yield and post-harvest quality of strawberry fruit in the region. We conducted two field experiments in Victoria (Coldstream and Warburton) to evaluate the effectiveness of a commercial seaweed extract from Durvillaea potatorum and Ascophyllum nodosum (Seasol®) on the yield, revenue, and post-harvest rot of strawberry fruit. We applied the extract to strawberry crops (cv. Albion) monthly as a combined drench (10 L ha-1) and foliar spray (1:400), with water as a control. Application of the seaweed extract significantly increased strawberry fruit yields by 8-10% and revenue by AU$0.37-0.59 per plant. Furthermore, the extract significantly reduced the incidence and severity of post-harvest rots in strawberry fruit by 52-87%, respectively. The extract did not affect the firmness, soluble solids concentration (SSC), titratable acidity, or SSC:acid of strawberry fruit. In a separate laboratory experiment, we found that growing strawberry in the seaweed extract (1:400) increased the concentration of peroxidase by 50% and doubled H2O2 in roots soon after treatment. Increases in reactive oxygen species are an indicator of a suite of pathways associated with resistance and tolerance of biotic and abiotic stresses. Overall, the results demonstrate that the seaweed extract can act as a commercially-viable biostimulant for strawberry fruit production in south-eastern Australia.
The Oligopolistic Behavior of Kazakh and Russian Wheat Exporters in the South Caucasus: Evidence from a Residual Demand Elasticity Analysis
Authors: Gafarova Gulmira , Perekhozhuk Oleksandr , Glauben Thomas 
Published: May 2023

Abstract This study looks at whether Kazakh and Russian wheat exporters leverage their dominant share of the wheat markets in the South Caucasus to exercise market power. We apply a three-stage estimation for systems of simultaneous equations and Zellner’s seemingly unrelated regression to analyze residual demand elasticity. The results of both estimations provide empirical evidence of Russian market power in the wheat markets of the South Caucasus but no evidence of a Kazakh oligopoly. Russian exporters possess greater market power in Armenia than in Georgia. Market power depends on the presence of competitors in the destination market. The results show that Kazakh exporters restrict the market powers of Russian exporters in the Azerbaijani wheat market, while Russian exporters constrain the market power of Kazakh exporters in the Azerbaijani and Georgian wheat markets. Ukrainian wheat exporters are able to intervene in the market powers of Russian exporters in Azerbaijan and Georgia, while they restrict Kazakh oligopoly in the Georgian market. Some export restrictions imposed by wheat exporting countries significantly affected competition in wheat importing countries. Russia’s ongoing war against Ukraine and the blockade of Ukrainian ports on the Sea of Azov and the Black Sea are restricting wheat trade, severely damaging Ukraine’s competitiveness and export potential, and reducing food security in the South Caucasus, the Middle East, and North Africa.
New peripheries in the making? Analysing German cities from the lens of a suburbanisation of poverty
Authors: Weck Sabine , Dobusch Diane , Pfaffenbach Carmella , Fina Stefan , Schmitz Julian 
Published: May 2023

AbstractIn this paper we discuss evidence on new socio-spatial patterns in the relation between urban and suburban areas due to the involuntary outward residential mobility of low-income households from central urban areas. Our findings build upon research in three German cities from a comparative perspective, with interviews with local experts providing the main source of information. For analysing decentralisation or suburbanisation of poverty processes we focus on the role of the urban housing market, residential settlement changes, and the role of social security systems. We cannot confirm the displacement of low-income households beyond city limits as a general trend. Instead, our findings reveal a local and context-dependent variation of socio-spatial shifts in the three investigated cities, related to city-specific housing market and urban development factors. As a general factor, existing social security systems continue to work towards keeping low-income households inside cities, seemingly preventing a large-scale suburbanisation of poverty. There is, however, a worrying trend in the concentration of low-income households in ever-decreasing segments of affordable housing, alongside increasing burdens on low-income households coping with the current challenges of a housing affordability crisis. City-regional monitoring and further research are needed.