bluuebunny/crossref_metadata_2025_split huggingface dataset:
The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
Authors: McDaid W. J. , Wilson L. , Adderley H. , Baker M. J. , Searle J. , Ginn L. , Budden T. , Aldea M. , Marinello A. , Aredo J. , Viros A. , Besse B. , Wakelee H. A. , Blackhall F. , Lindsay C. R. , Malliri A. 
Published: September 2023

AbstractIntroductionKRASG12Cand KRASG12Dinhibitors represent a major translational breakthrough for non-small cell lung cancer (NSCLC) and cancer in general by directly targeting its most mutated oncoprotein. However, resistance to these small molecules has highlighted the need for rational combination partners necessitating a critical understanding of signaling downstream of KRAS mutant isoforms.MethodsWe contrasted tumor development betweenKrasG12CandKrasG12Dgenetically engineered mouse models (GEMMs). To corroborate findings and determine mutant subtype-specific dependencies, isogenic models ofKrasG12CandKrasG12Dinitiation and adaptation were profiled by RNA sequencing. We also employed cell line models of established KRAS mutant NSCLC and determined therapeutic vulnerabilities through pharmacological inhibition. We analysed differences in survival outcomes for patients affected by advancedKRASG12CorKRASG12D-mutant NSCLC.ResultsKRASG12Dexhibited higher potencyin vivo, manifesting as more rapid lung tumor formation and reduced survival of KRASG12DGEMMs compared to KRASG12C. This increased potency, recapitulated in an isogenic initiation model, was associated with enhanced PI3K-AKT-mTOR signaling. However, KRASG12Concogenicity and downstream pathway activation were comparable with KRASG12Dat later stages of tumorigenesisin vitroandin vivo, consistent with similar clinical outcomes in patients. Despite this, established KRASG12DNSCLC models depended more on the PI3K-AKT-mTOR pathway, while KRASG12Cmodels on the MAPK pathway. Specifically, KRASG12Dinhibition was synergistically enhanced by AKT inhibition.ConclusionsOur data highlight a unique combination treatment vulnerability and suggest that patient selection strategies for combination approaches using direct KRAS inhibitors should be i) contextualised to individual RAS mutants, and ii) tailored to their downstream signaling.
Changes in accounting estimates during the COVID-19 pandemic in the USA
Authors: Li Valerie , Luo Yan 
Published: September 2023

PurposeThe authors investigate how managers adapt their financial reporting and disclosure practices in response to the COVID-19 pandemic through changes in accounting estimates (CAEs).Design/methodology/approachThe authors define the pandemic period as starting on March 1, 2020. The sample consists of 9,575 CAEs disclosed in quarterly (10-Qs) and annual (10-Ks) financial reports by US firms between January 1, 2004 and May 31, 2022. The authors perform multivariate analyses of the impact of the COVID-19 pandemic on the incidence of CAEs and on whether the impact of CAEs on firms' financial performance and reporting quality changes during the pandemic.FindingsIn the examination of the CAE footnote disclosures in the quarterly (10-Qs) and annual (10-Ks) reports of US companies, the authors find no evidence that the incidence of CAEs in 10-Ks or the number of firms reporting CAEs are significantly different in the pre-pandemic and pandemic periods, but the incidence of CAEs in 10-Qs is significantly higher in the pandemic period than in the pre-pandemic period. The authors also find that the number of CAEs related to revenue recognition increase significantly in the pandemic period, but CAEs in other categories decrease, with the sharpest drop seen in the liabilities category. Further investigation suggests that although the dollar impact of 10-K CAEs on current financial statements is higher during the pandemic period, firms with CAEs, especially positive CAEs, in either 10-Ks or 10-Qs are less likely to use CAEs to boost earnings in the pandemic period. However, the authors find evidence that firms tend to use CAEs to “big bath” current earnings and create reserve for future period. The authors have not observed any significant differences in how the various phases of the pandemic affect the reporting of CAEs. Additionally, there is no evidence to suggest that financially distressed firms report more or fewer CAEs during the pandemic.Practical implicationsThe results are consistent with the notion that, during the pandemic, firms exercise greater caution in their CAE disclosures, refraining from using CAEs as a means of boosting earnings but as a strategy to create reserve for future period. The paper highlights the challenges that various stakeholders face when assessing a company's current and future financial performance based on management's accounting estimates.Originality/valueThis study captures the impact of the COVID-19 pandemic on the incidence of CAEs and CAEs' impact on the financial performance and financial reporting quality of firms during the pandemic.
The nexus between social media advertising and customers’ purchase intention with the mediating role of customers’ brand consciousness: evidence from three South Asian countries
Authors: Hosain Md Sajjad , Mamun Abdullah Mohammad Ahshanul 
Published: September 2023

PurposeThis empirical paper is an endeavor to explore the relationship between social media advertising (SMA) and customers' purchase intention (CPI) in three South Asian countries. SMA was further divided into three relevant dimensions: perceived relevance (PR), perceived informativeness (PI) and perceived credibility (PC). Furthermore, the authors incorporated a single mediator: customers' brand consciousness (CBC) to test the mediating effects on the direct relationships.Design/methodology/approachThe authors purposively selected 1937 fashion-conscious individuals based on a cross-sectional survey design. The authors applied SPSS 25 for explanatory statistics and structural equation modeling (SEM) (through AMOS 25) for testing the hypothesized relationships.FindingsBased on the responses and the application of statistical measures, the authors revealed that all of the three dimensions of SMA have significant positive relationships with CPI. CBC is also significantly and positively related to CPI. Regarding the mediating effects, CBC was identified to have full mediation effects on the relationships between PR and CPI and PI and CPI. On the contrary, the same variable was found to have partial mediation on the relationship between PC and CPI.Originality/valueSouth Asia is a growing business hub and the largest consumer market in terms of population. This empirical study was undertaken to reveal the role of SMA on CPI in the three highly populated South Asian countries, which is rare in academia. The outcomes of this empirical study are expected to be useful for further research attempts regarding SMA and consumer behavior. Businesses and policymakers are also expected to benefit from formulating SMA-related strategies to retain present buyers as well as attract the prospective ones.
Abolee: way forward in rural markets
Authors: Chatterjee Joyee 
Published: September 2023

Learning outcomes
The learning outcomes of this study are as follows:
Teaching Objective 1: Students will describe specific characteristics of the rural market in India and will draw out the differences vis-a-vis the urban markets.
Teaching Objective 2: Students will describe about the push versus pull strategy and various channels of distribution in rural areas.
Teaching Objective 3: The students will explain the 4As of the rural marketing mix and apply the same in the context of the case.
Teaching Objective 4: The case can be applied with respect to the health-belief model to help students analyse the behaviour change model.
Teaching Objective 5: Students will analyse the challenges associated with supply chain and logistics in rural areas.

Case overview/synopsis
This case study looked at a start-up company Rugved Hygienecare Industries Private Limited and their sanitary napkin brand “Abolee” designed and targeted for rural women in India. Onkar Charegaonkar and Mithila Charegaonkar started this venture in December 2017, realizing that sanitary napkins solved a greater purpose of helping women hygienically manage menstruation, and at the same time, there was no threat to this product because over a period of time, it became a necessity of life. Onkar and Mithila believed in giving back to the society and at the same time generate revenue for their company. Onkar and Mithila needed to make a decision with respect to the distribution structure for Abolee to improve penetration in different rural areas of Maharashtra. Onkar and Mithila needed to strategize to create a remarkable impact in the rural areas. There were multiple challenges that were faced by Abolee, such as: creating awareness about hygienically managing menstruation options among women, ensuring that women consumers continue to use hygienic menstruation management material, creating a preference for Abolee among women consumers and deciding on whether to focus on driving sales through existing channel partners or to invest in finding out alternative avenues for selling “Abolee” in rural areas.

Complexity academic level
This case study was primarily written for understanding rural marketing aspects of marketing management courses at both the undergraduate level and the postgraduate level. This case study also indicated about the role of gender and its impact on consumer behaviour in rural areas. Although this case study was related to the rural Indian market, it can also be related to other emerging economies.

Supplementary material
Teaching notes are available for educators only.

Subject code
CSS8: Marketing.
Measuring local public expenditure effectiveness using sustainable development goals
Authors: Matos Sandra , Jorge Susana , Moura e Sá Patrícia 
Published: September 2023

PurposeThis paper aims to propose a tool to assess local public expenditure effectiveness based on a framework of alignment between outputs, outcomes and impacts – the Index of Municipal Expenditure Effectiveness (IMEE). This index is composed of a set of indicators associated with the typology of local expenditure.Design/methodology/approachThe paper describes the methodological approach used in the development of the Index, considering the insights from the literature review and the opinion of a panel of experts. The indicators of outcomes and social impacts that are part of the Index are intentionally aligned with the UN Sustainable Development Goals (SDGs) as they provide an essential guide to assess public value creation in the current context. For simplicity purposes, three main components of municipal expenditure were considered, namely Education, Essential Public Services and Local Public Transportation. The Index is then illustrated through a pilot application, using data from five Portuguese municipalities.FindingsThis study argues that measuring the public expenditure effectiveness based on outcome and impact indicators can provide the data needed for local governments to better understand the effects of their activities over time, ultimately assessing their contribution to public value.Practical implicationsAssessing the impact of local spending is important to ensure the best use of public resources. Linking local public expenditures with the 2030 Agenda and the SDGs is a promising avenue to understand up to what extent the application of the public money is contributing to create public value by impacting on citizens’ lives.Originality/valueThe proposed IMEE contributes to addressing a gap identified in public organizations, including local governments, regarding the lack of consideration of expenditure and outcome/impact relationships, and the use of variables to measure long term impacts.
Factors influencing older adults' intention to use virtual fitting room technology during the COVID-19 pandemic
Authors: Hwang Chanmi , Jin Byoungho , Song Linfeng , Feng Jing 
Published: September 2023

PurposeThe purpose of this paper is to examine the factors that influence older adults' intention to use virtual fitting room technology during the COVID-19 pandemic based on the extended technology acceptance model (TAM).Design/methodology/approachAn online survey was conducted with a sample of older adults from 60 to 90 years old (n = 819). A structural equation modeling was conducted to test a proposed research model.FindingsThe results revealed that older adults' behavioral intentions were positively influenced by perceived usefulness and ease of use, and fear of infection during the pandemic was significantly related to the perceived usefulness. Fit concern was not significantly related to perceived usefulness of virtual fitting room technology.OriginalityThis research extends the TAM by adding antecedents to perceived usefulness in explaining older adults' adoption of virtual fitting technology.
Discussing the applicability of the maintenance management framework for asset management (MMFAM): a hydroelectric power plant case study
Authors: da Silva Renan Favarão , de Souza Gilberto Francisco Martha 
Published: September 2023

PurposeThe Maintenance Management Framework for Asset Management (MMFAM) is a recently modeled framework to ensure the alignment of maintenance management with physical asset management based on the ISO 55000 series for asset management. In this context, the purpose of this paper is to discuss the applicability of the MMFAM considering the operational context of a hydroelectric power plant.Design/methodology/approachThe paper adopted the case study method for the discussion of the applicability of the MMFAM to a real operational context. A hydroelectric power plant was chosen as the scope of the case study due to its relevance since the electricity sector is an example of an asset-intensive industry in which asset management performance is fundamental. To gain a detailed understanding of the organization, data were collected through direct requests to the plant, informal meetings with technical collaborators, a technical visit to the hydroelectric plant and on-site data collection. Then, the MMFAM processes were demonstrated based on this information and the results supported the discussion of the MMFAM applicability.FindingsThe case study provided a deeper understanding of the processes included in the MMFAM. In addition, the results suggested the applicability of the framework to other organizations besides the hydroelectric sector due to its generic approach and the possibility of choosing appropriate tools to support and implement the MMFAM processes.Practical implicationsThe case study is expected to contribute to the practical understanding of the MMFAM processes within an operational context and assist maintenance professionals and researchers in their implementation in other organizations.Originality/valueAlthough the literature provides different maintenance management frameworks, their practical discussion based on a real operational context is still a gap. Accordingly, this paper discusses the MMFAM under a case study method to expand its understanding beyond theory and contribute to practical comprehension in depth.
Building and nurturing a learning culture: a cross-dynamic and interactional perspective
Authors: Alves Sarah , Thiebaut Edouard 
Published: September 2023

Purpose
If building and nurturing a learning organization is not a random chance, the question of where organizations should start is patent. Because learning culture is one of the core components of learning organizations, it is wondered how individuals and organizations contribute to this phenomenon. Under an interactional perspective, the authors explore the cross-dynamics between learning resources, structure and support (organizational level), and self-directed learning (individual level).

Design/methodology/approach
The authors conducted qualitative and exploratory research in Spring 2021 in France. They used semi-structured interviews with HRMs and a Delphi panel as the main instruments. This dual approach brings a reflexive and complementary dialogue to the research question.

Findings
The results show that non-learning organizations took advantage of the Covid-19 period. They created a learning biotope and fostered learning dynamics. Although this biotope acted as a learning marketplace and lacked guidance, individuals interacted with this learning biotope. They took learning initiatives and developed their self-directed learning. This understanding argues for constant interaction and co-influence between organizations and individuals to build and nurture a learning culture.

Originality/value
There is little discussion on how individuals and organizations contribute to building and nurturing a learning culture from an interactional perspective. Furthermore, literature on learning organizations considers self-directedness as a whole, considering self-directed learning as a characteristic and a process sharpens thinking. On methodological concerns, the authors used a dual qualitative approach with interviews and Delphi for the first time in research on learning organizations.
War in World Society: Towards a new order of global constitutionalism?
Authors: Brunkhorst Hauke 
Published: September 2023

AbstractIn world society, all wars are world wars and so is the present war in Ukraine even if the use of violence is broadly restricted to the Ukrainian area (a restriction imposed clearly imposed by global politics). World society emerged between 1750 and 1850 together with the first world wars and world revolutions that were fought on all continents and oceans (1). There is no society beyond world society any longer. The world society pushes (but by no means sufficiently) (a) law and politics to institutionalise a world constitution and (b) social actors to culturally symbolise global mindsets, world views and normativity (2). Yet, only a second wave of world revolutions and world wars between 1900 and 1950 caused the rise of autonomous world law that enabled a now interrupted but still lasting global process of fully inclusive democratisation (3). However, the rise of world law in 1945 was followed by its fall after 1989, and the present wars in Ukraine and beyond come close to a complete destruction of world law. There is only a small chance to end the use of violence in Ukraine that cannot and should not lead to sufficient victory of one of the warring parties but to a reconstruction and new foundation of world law and the constitutional order of the world. The alternative is not the national state but failed states and anomia (4).
Maternal and paternal risk factors for fetal alcohol spectrum disorders: Alcohol and other drug use as proximal influences
Authors: May Philip A. , Hasken Julie M. , de Vries Marlene M. , Marais Anna‐Susan , Abdul‐Rahman Omar , Robinson Luther K. , Adam Margaret P. , Manning Melanie A. , Kalberg Wendy O. , Buckley David , Seedat Soraya , Parry Charles D. H. , Hoyme H. Eugene 
Published: September 2023

AbstractObjectiveTo explore and analyze the significance of proximal influences of maternal and paternal traits associated with bearing a child with a fetal alcohol spectrum disorder (FASD).MethodsAggregated, maternal interview‐collected data (N = 2515) concerning alcohol, tobacco, and other drug use were examined to determine risk for FASD from seven cross‐sectional samples of mothers of first‐grade students who were evaluated for a possible diagnosis of FASD.ResultsMothers of children with fetal alcohol syndrome (FAS) reported the highest alcohol use throughout pregnancy, proportion of binge drinking, drinks per drinking day (DDD), drinking days per week, and total drinks per week. Mothers of children with FAS also consumed significantly more alcohol than mothers of children with partial FAS (PFAS), alcohol‐related neurodevelopmental disorder (ARND), or typically developing controls. Mothers of children with PFAS and ARND reported similar drinking patterns, which exposed fetuses to 3–4 times more alcohol than mothers of controls, but the PFAS group was more likely than the ARND group to abstain in latter trimesters. Fathers of all children were predominantly drinkers (70%–85%), but more fathers of children with FASD binged heavily on more days than fathers of controls. Compared to the few mothers of controls who used alcohol during pregnancy, the ARND group binge drank more (3+ DDD) throughout pregnancy and drank more DDD before pregnancy and first trimester. Regression analysis, controlling for tobacco use, indicated that mothers who reported drinking <1 DDD were significantly more likely than abstainers to bear a child with FASD (OR = 2.75) as were those reporting higher levels such as 5–5.9 DDD (OR = 32.99). Exclusive, first‐trimester maternal drinking increased risk for FASD five times over that of abstinence (p < 0.001, OR = 5.05, 95% CI: 3.88–6.58), first‐ and second‐trimester drinking by 12.4 times, and drinking all trimesters by 16 times (p < 0.001, OR = 15.69, 95% CI: 11.92–20.64). Paternal drinking during and prior to pregnancy, without adjustment, increased the likelihood of FASD significantly (OR = 1.06 and 1.11, respectively), but the significance of both relationships disappeared when maternal alcohol and tobacco use were controlled.ConclusionsDifferences in FASD risk emerged from the examination of multiple proximal variables of maternal alcohol and tobacco use, reflecting increased FASD risk at greater levels of maternal alcohol consumption.
End‐ischemic hypothermic oxygenated machine perfusion does not improve renal outcome following liver transplantation from aged donors: A single‐center retrospective report
Authors: Norén Åsa , Mölne Johan , Bennet William , Sörensen Gustaf , Herlenius Gustaf , Lindnér Per , Oltean Mihai 
Published: September 2023

AbstractBackgroundOrgan transplantation using grafts from elderly donors entails a higher risk for severe ischemia‐reperfusion injury (IRI). Advanced IRI after liver transplantation (LT) seems to be associated with the development of acute kidney injury (AKI). We studied if end‐ischemic hypothermic oxygenated machine perfusion (HOPE) of liver grafts, aimed at mitigating liver IRI, impacts on the frequency and severity of AKI after LT.MethodsLTs performed at our center between January 2017 and December 2022 using organs from deceased brain‐dead donors aged 70 or older were reviewed. From November 2020 on, HOPE was performed routinely in this donor category. The frequency and severity of AKI (KDIGO criteria) within 48 hours of graft reperfusion and the model of early allograft function (MEAF) were compared between HOPE‐LTs (n = 30) and control LTs (n = 71).ResultsAKI developed in 23/30 (77%) HOPE‐LTs and in 40/71 (56%) control LTs (p = n.s.), with no difference in severity and timing between groups. Renal replacement therapy was required in 3/30 (10%) HOPE‐LTs and 6/71 (8%) control LTs. In addition, transaminase leak during the first week (marker of IRI) and MEAF were similar between groups. These findings persisted after propensity matching. Histology showed more hepatocyte vacuolization and higher Suzuki score in HOPE‐LTs. Although this analysis could have been underpowered, no trends supporting the benefit of HOPE on liver and renal injury after LT were ever identified.ConclusionsIn conclusion, HOPE in this group of older donors does not seem to improve either graft IRI, or the incidence of early AKI after LT.