bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bayesian spatio‐temporal survival analysis for all types of censoring with application to a wildlife disease study
Authors: Yao Kehui , Zhu Jun , O'Brien Daniel J. , Walsh Daniel 
Published: August 2023

AbstractIn this article, we consider modeling arbitrarily censored survival data with spatio‐temporal covariates. We demonstrate that under the piecewise constant hazard function, the likelihood for uncensored or right‐censored subjects is proportional to the likelihood of multiple conditionally independent Poisson random variables. To address left‐ or interval‐censored subjects, we propose to impute the exact event times and convert them into uncensored subjects, enabling the application of the integrated nested Laplace approximation to update model parameters using the imputed data. We introduce an iterative algorithm that alternates between imputing event times for left‐ and interval‐censored subjects and re‐estimating model parameters. The proposed method is assessed through a simulation study and applied to analyze a spatio‐temporal survival dataset in a wildlife disease study investigating bovine tuberculosis in white‐tailed deer in Michigan.
Predicting gully erosion susceptibility in South Africa by integrating literature directives with regional spatial data
Authors: Olivier George , Van De Wiel Marco J. , de Clercq Willem P. 
Published: August 2023

AbstractGully erosion has been identified as a severe land degradation process with environmental and socio‐economic consequences. Identifying areas susceptible to gully erosion will aid in developing strategies to inhibit future degradation. Various approaches have been implemented to predict and map gully erosion susceptibility but are mostly restricted to small geographical extents because of process limitations. Here, we introduce a novel method that predicts gully erosion susceptibility on a regional/national scale (1.22 million km2) by synthesising literature directives with a statistical approach. Findings from a literature review were used to extract physiographic properties associated with gully erosion that was conditioned to characterise susceptibility by using the Frequency Ratio model. The conditioned physiographic properties were aggregated by a weighted overlay procedure using an aggregation of controlling factors derived from the literature review as a weighting system. The gully susceptibility index (GSI) model was validated against a published gully inventory map (n = 163 019) and randomly generated 1‐km2 tessellation zones from which primary validation data were derived. Although uncertainties within the modelling procedure exist (e.g., gully site distribution, the spatial resolution of input data and determination of gully points), the validation shows that the GSI model is generally robust, identifying areas of contrasting susceptibilities. Furthermore, findings converge with other susceptibility metrics, which have been derived by different methodologies. Because empirical gully erosion research has been conducted worldwide, this model could be applied to regional‐scale gully susceptibility modelling assessments (as a solitary method or combined with primary data) in other parts of the world. Additionally, the GSI model can be adopted to model environmental change scenarios.
The multifactor pelvis: An alternative to the adaptationist approach of the obstetrical dilemma
Authors: Warrener Anna 
Published: August 2023

AbstractThe obstetrical dilemma describes the competing demands that a bipedally adapted pelvis and a large‐brained neonate place on human childbirth and is the predominant model within which hypotheses about the evolution of the pelvis are framed. I argue the obstetrical dilemma follows the adaptationist program outlined by Gould and Lewontin in 1979 and should be replaced with a new model, the multifactor pelvis. This change will allow thorough consideration of nonadaptive explanations for the evolution of the human pelvis and avoid negative social impacts from considering human childbirth inherently dangerous. First, the atomization of the pelvis into discrete traits is discussed, after which current evidence for both adaptive and nonadaptive hypotheses is evaluated, including childbirth, locomotion, shared genetics with other traits under selection, evolutionary history, genetic drift, and environmental and epigenetic influences on the pelvis.
Induction of more aggressive tumoral phenotypes in LNCaP and PC3 cells by serum exosomes from prostate cancer patients
Authors: Huertas‐Lárez Raquel , Muñoz‐Moreno Laura , Recio‐Aldavero Jorge , Román Irene Dolores , Arenas María Isabel , Blasco Ana , Sanchís‐Bonet Ángeles , Bajo Ana M. 
Published: August 2023

AbstractProstate cancer (PCa) is the second most frequent and sixth most fatal cancer in men worldwide. Despite its high prevalence, our understanding of its etiology and the molecular mechanisms involved in the progression of the disease is substantially limited. In recent years, the potential participation of exosomes in this process has been suggested. Therefore, we aim to study the effect of exosomes isolated from the serum of patients with PCa on various cellular processes associated with increased tumor aggressiveness in two PCa cell lines: LNCaP‐FGC and PC3. The exosomes were isolated by filtration wand ultracentrifugation. Their presence was confirmed by immunodetection of specific markers and their size distribution was analyzed by Dynamic Light Scattering (DLS). The results obtained demonstrated that serum exosomes from PCa patients increased migration of PC3 cells and neuroendocrine differentiation of LNCaP‐FGC cells regardless of the grade of the tumor. PCa serum exosomes also enhanced the secretion of enzymes related to invasiveness and resistance to chemotherapeutics, such as extracellular matrix metalloproteases 2 and 9, and gamma‐glutamyltransferase in both cell lines. Altogether, these findings support the pivotal participation of exosomes released by tumoral cells in the progression of PCa. Future studies on the molecular mechanisms involved in the observed changes could provide crucial information on this disease and help in the discovery of new therapeutic targets.
First case report of serous otitis media as a complication of severe ovarian hyperstimulation syndrome: Case report and literature review
Authors: Santistevan Lucia , Lonergan Devin , Eyvazzadeh Aimee D. 
Published: August 2023

AbstractOvarian hyperstimulation syndrome (OHSS) may be a severe complication of controlled ovarian hyperstimulation during assisted reproductive technology. During OHSS, fluid shifts from the intravascular space to the third‐space compartments as the result of an increase in capillary permeability. This can cause fluid accumulation in peritoneal as well as thoracic cavities. The patient presented with symptoms of severe OHSS (bilateral hydrothorax and pulmonary effusion), requiring bilateral ultrasound‐guided paracentesis and bilateral thoracentesis during her Emergency Room visits and hospitalization. Due to distant effects from the increased capillary permeability, the patient presented fluid in the middle ear, which led to the development of serous otitis media 12 days after egg retrieval. This was resolved 2–3 weeks later after being treated with antihistamines and antibiotics given by her Ear, Nose, and Throat doctor. OHSS risk may be reduced by continuous monitoring of patients undergoing ovulation induction, using an appropriate gonadotropin dosage, and using additional agents known to decrease its risk. If OHSS still occurs, symptomatic treatment and a multidisciplinary team of professionals may be needed to prevent fluid build‐up complications. In contrast to many published articles about OHSS and its complications, this is the first case report of a patient presenting serous otitis media as a complication of severe OHSS.
Dark side ofIT: A misleading expression?
Authors: Masiero Silvia 
Published: August 2023

AbstractResearch on the “dark side” of information technology (IT) is becoming diffused in the information systems (IS) field. Focused on the negative consequences of IT on individuals, organizations and the society, such a literature has, however, neglected the contribution of ICT4D research to the debate. This paper draws on two streams of research—respectively, on digital identity systems for social protection and biometric humanitarianism—to highlight the limits of the notion of a “dark side” of IT. Using a design justice lens, it illuminates how adverse features can be purposefully designed into technology, directly producing the detrimental outcomes that cause harm on its users. Through this perspective, the notion of a “dark side” of IT is contrasted with that of a “dark matter” pointing to the substantial, rather than accidental, nature of harm generated through IT. Implications are drawn for IS research, highlighting how existing works from the ICT4D field support the “dark matter” thesis.
The distinguishing index of graphs with infinite minimum degree
Authors: Stawiski Marcin , Wilson Trevor M. 
Published: August 2023

AbstractThe distinguishing index of a graph is the least number of colors necessary to obtain an edge coloring of that is preserved only by the trivial automorphism. We show that if is a connected ‐regular graph for some infinite cardinal then , proving a conjecture of Lehner, Pilśniak, and Stawiski. We also show that if is a graph with infinite minimum degree and at most vertices of degree for every infinite cardinal , then . In particular, if has infinite minimum degree and order at most .
セルトラリンの大量内服により急性薬剤性肺障害を生じた1例(Drug–induced lung injury caused by sertraline overdose: a case report)
Authors: 愛 栁内 , 縁 後藤 , 太郎 田中 , 喜己 北川 
Published: August 2023

要旨セルトラリンは選択的セロトニン再取り込み阻害薬の一つでうつ病の治療に用いられる。我々はセルトラリンの大量内服により急性薬剤性肺障害を生じた症例を経験した。セルトラリンの添付文書に肺障害の記載はなく，本邦での報告もない。症例は36歳の女性。既往はうつ病。自殺目的でセルトラリン100mgを100錠服用し搬送された。来院時，血圧 119/79mmHg，脈拍 96/分，呼吸数 22/分，SpO2 96%，Glasgow coma scale E3V4M6。検査上特異的な異常はなく，急性薬物中毒として入院した。第2病日に発熱，第5病日にSpO2低下を生じ，胸部単純CTで両側全肺野のすりガラス影を認めた。気管支肺胞洗浄液は血性で好中球優位であり肺胞出血を示唆した。膠原病肺を念頭にメチルプレドニゾロン（mPSL）60mg/日を開始したところ，一時的に呼吸状態が改善した。同時にセルトラリンによる薬剤性肺炎も疑いDLSTを提出したが，頻度の低さと中止に伴う離脱症候群などのリスクを考慮し，内服は継続した。第17病日に再び呼吸状態が悪化し，胸部CT上，びまん性肺胞傷害および縦隔気腫・気胸を認めた。DLSTが陽性と判明したため薬剤性肺障害と診断し，薬剤中止とmPSLパルスを施行したところ奏功し，退院に至った。稀だが重症な薬剤性肺障害の原因としてセルトラリンを念頭におくことは，早期診断・治療につながる。
早期に胸腔鏡下食道切除を行った腐食性食道炎による食道狭窄の1例(A case of the early thoracoscopic esophagectomy for esophageal stricture due to corrosive esophagitis)
Authors: 源 鈴木 , 勝伸 勅使河原 , 大輔 山本 , 早紀 坂本 , 昌士 五木田 , 茂正 田口 , 和也 清田 
Published: August 2023

要旨　腐食性食道炎は時間の経過に伴って，食道と周囲組織の癒着が進行するため，手術を行う場合には操作が困難になると考えられる。我々は，早期に鏡視下切除を行った腐食性食道炎による食道狭窄の症例を経験したため報告する。症例は50歳の男性。自殺企図で濃度不明の硝酸25mLほど内服し，救急要請された。造影CTと上部消化管内視鏡検査（esophagogastroduodenoscopy: EGD）で，腐食性食道炎・胃炎の診断となり，経過観察の方針で入院とした。EGDのフォローアップで胸部食道に狭窄を認めた。第33病日には胸部下部食道の内腔は5mm以下となった。狭窄は進行性であり第35，40病日にバルーン拡張術を実施するも効果は一時的であった。また，嚥下障害も合併した。第44病日に胸腔鏡下胸部食道切除，頚部食道唾液瘻造設，腹腔鏡下胃瘻造設術を行った。食道周囲の剥離の際に癒着や瘢痕形成は認めず，容易に剥離を行うことができた。嚥下障害が改善したため，2期的再建として，第84病日に大弯側胃管を用いた食道再建（胸骨後経路）を行い，第134病日に独歩退院とした。早期に手術を行うことで比較的難易度が低い状態で，低侵襲な胸腔鏡下食道切除術を安全に行うことが可能であった。
Analysis of the Correlation and Prognostic Significance of Tertiary Lymphoid Structures in Breast Cancer: A Radiomics‐Clinical Integration Approach
Authors: Li Kezhen , Ji Juan , Li Simin , Yang Man , Che Yurou , Xu Zhu , Zhang Yiyao , Wang Mei , Fang Zengyi , Luo Liping , Wu Chuan , Lai Xin , Dong Juan , Zhang Xinlan , Zhao Na , Liu Yang , Wang Weidong 
Published: August 2023

BackgroundTertiary lymphoid structures (TLSs) are potential prognostic indicators. Radiomics may help reduce unnecessary invasive operations.PurposeTo analyze the association between TLSs and prognosis, and to establish a nomogram model to evaluate the expression of TLSs in breast cancer (BC) patients.Study TypeRetrospective.PopulationTwo hundred forty‐two patients with localized primary BC (confirmed by surgery) were divided into BC + TLS group (N = 122) and BC − TLS group (N = 120).Field Strength/Sequence3.0T; Caipirinha‐Dixon‐TWIST‐volume interpolated breath‐hold sequence for dynamic contrast‐enhanced (DCE) MRI and inversion‐recovery turbo spin echo sequence for T2‐weighted imaging (T2WI).AssessmentThree models for differentiating BC + TLS and BC − TLS were developed: 1) a clinical model, 2) a radiomics signature model, and 3) a combined clinical and radiomics (nomogram) model. The overall survival (OS), distant metastasis‐free survival (DMFS), and disease‐free survival (DFS) were compared to evaluate the prognostic value of TLSs.Statistical TestsLASSO algorithm and ANOVA were used to select highly correlated features. Clinical relevant variables were identified by multivariable logistic regression. Model performance was evaluated by the area under the receiver operating characteristic (ROC) curve (AUC), and through decision curve analysis (DCA). The Kaplan–Meier method was used to calculate the survival rate.ResultsThe radiomics signature model (training: AUC 0.766; test: AUC 0.749) and the nomogram model (training: AUC 0.820; test: AUC 0.749) showed better validation performance than the clinical model. DCA showed that the nomogram model had a higher net benefit than the other models. The median follow‐up time was 52 months. While there was no significant difference in 3‐year OS (P = 0.22) between BC + TLS and BC − TLS patients, there were significant differences in 3‐year DFS and 3‐year DMFS between the two groups.Data ConclusionThe nomogram model performs well in distinguishing the presence or absence of TLS. BC + TLS patients had higher long‐term disease control rates and better prognoses than those without TLS.Evidence Level2Technical EfficacyStage 2
Overcoming uncertainty: A framework to guide the implementation of Australian radiation therapy advanced practitioners
Authors: Matthews Kristie , Duchesne Gillian 
Published: August 2023

AbstractIntroductionThe implementation of radiation therapy advanced practice in Australia has not yet been broadly realised. With anticipated growing demands on cancer services, it is imperative to understand why this is the case, and to strategise a way forward. As a result, we explored the factors influencing the implementation of advanced practitioner radiation therapists (APRT) in Australia. The research outcome was a complex process of Navigating Uncertainty, which described the contextual, social and personal factors surrounding implementation successes and challenges. Further synthesis of the findings was undertaken to highlight the fundamental features influencing this process, with the intention to provide a useful understanding for practitioners seeking APRT implementation.MethodsData were collected through national online focus groups and case studies with 53 participants. Analysis identified a constructivist grounded theory process of Navigating Uncertainty. Further analysis of the categories and properties of the process was undertaken to synthesise findings at a higher level of abstraction.ResultsFour overarching and intertwined factors were influencing the implementation of APRT. Uncertainty occurred when practitioners attempted to conceptualise and assimilate the new role into the workplace. Power was apparent in the advocacy and legitimisation of the APRT by centre leaders. Value was vital to achieving purposeful outcomes. Identity was evident in the personal transition of the APRT, and in the boundary work with others.ConclusionRecognising and negotiating uncertainty, power, value and identity is essential for APRT implementation strategies to succeed. A framework to guide practitioners towards the implementation of APRT has been described that embodies these factors.
Immunovirology of cytomegalovirus infection in allogeneic stem cell transplant recipients undergoing prophylaxis with letermovir: A narrative review
Authors: Solano Carlos , Giménez Estela , Albert Eliseo , Piñana José L. , Navarro David 
Published: August 2023

AbstractOn November 7, 2017, the US Food and Drug Administration approved the use of letermovir (LMV) for prophylaxis of cytomegalovirus (CMV) infection in adult CMV‐seropositive allogeneic stem cell transplant recipients. After 6 years of use, a large body of real‐world experience has been accumulated that validates the Phase III clinical trial results, in which LMV was shown to significantly reduce the risk of clinically significant CMV infection—defined as CMV end‐organ disease or CMV DNAemia requiring pre‐emptive antiviral therapy (PET)—and increase survival up to Week 24 after treatment inception. Notwithstanding, several issues still need to be settled, thus further investigation is required. First, since viral DNA may accumulate as a result of LMV‐driven abortive CMV infection, what is the optimal viral load threshold in the blood that would prompt LMV prophylaxis interruption and PET inception? Should this be adapted to the patient's risk? Second, what is the impact of LMV prophylaxis on the reconstitution of functional CMV‐specific T‐cell responses? Would it be a wise approach to individually tailor the duration of LMV treatment according to the number of peripheral blood CMV‐specific T cells at the end of regular prophylaxis? Third, how frequently do LMV‐resistant strains arise while patients are on LMV prophylaxis and how could this be minimized? Here, we discuss the literature addressing these topics.
Nonenzymatic hydrolysis of 1,2:3,4‐diepoxybutane: A kinetic study including pH, temperature, and ion effects
Authors: Romański Michał , Mikołajewski Jakub , Główka Franciszek 
Published: August 2023

Abstract1,3‐Butadiene is a carcinogenic and mutagenic air pollutant metabolized to butane epoxides, among which 1,2:3,4‐diepoxybutane (DEB) exhibits the highest genotoxicity. DEB is also formed by 1,3‐butadiene oxidation in the air, producing a direct environmental and occupational exposure. In this paper, we studied the kinetics of the nonenzymatic hydrolysis of DEB at a wide range of pH and temperature, including the catalytic effect of ionic species. The compound degradation involved a general and specific acid‐base catalysis of the epoxide ring hydrolysis. DEB had the greatest stability at pH 5–9, when the rates of acid‐catalyzed and base‐catalyzed hydrolysis are negligible and the neutral hydrolysis predominates. The capability of the buffer anions to accelerate the DEB decay increased in the order H2PO4− < HCO3− < CH3COO− < HPO42− < and CO32−. The Arrhenius equation well described the influence of temperature on the acid‐catalyzed, base‐catalyzed, and neutral hydrolysis rate constants. According to the obtained hydrolysis model coupled with the found thermodynamic parameters, the half‐life of DEB in natural fresh waters spans from 2 days at 30°C to 31 days at 0°C, but in the laboratory waste adjusted to pH 1or 13, the half‐life shortens to 2–3 h at 20°C. Therefore, the results of the paper help to assess the risk of exposure to the genotoxic action of DEB.
Sustainable use of gully agricultural land and water resources for sustainable development goals: A case study in the Loess Plateau of China
Authors: Qu Lulu , Liu Yansui , Li Yurui , Wang Jieyong , Yang Feng , Wang Yongsheng 
Published: August 2023

AbstractIn the context of global advocacy for Sustainable Development Goals (SDGs), agriculture and rural areas as the main carrying place of human production activities, is not only the focus area of SDGs, but also the focus point for the implementation of SDGs. Gully agricultural land and water resources (GALWR) sustainable use in China's Loess Plateau is vital to the evolution law of human–earth relationships and agricultural multi‐functional transformation for SDGs. However, the characteristics and patterns of GALWR and the optimization strategy are still unclear. Here, we identified the spatial distribution characteristics of GALWR and evaluated the carrying capacity of GALWR in the loess hilly and gully region (LHGR). We further investigated the driving factors for GALWR sustainable use and the optimization strategy of the dual guidance of economy and society as well as resources and ecology. The following results were obtained: (1) The distribution of cultivated land in the LHGR largely differed among districts and counties, with a higher distribution in the middle and a lower one on both sides. The matching degree of the GALWR was low, and the sensitivity analysis showed that the per capita water resources, the proportion of primary production, the drought index, and the vegetation coverage were the sensitive factors affecting the sustainable use of the GALWR in the LHGR. (2) There were obvious differences in the coupling and coordination of GALWR in the LHGR in 2020, and was a lack of synchronization regarding the GALWR use. (3) In order to form a gully rural regional functionalized and structured spatial structure system, the optimized strategy of GALWR for SDGs in the Loess Plateau was proposed according to adaptive management and the multi‐element coupling process of “water‐land‐climate‐crop” to protect gullies, rivers, forests, farmlands, and lakes in a coordinated way and in combination with land engineering control measures. This study provides a guideline for the transformation of agriculture and the construction of a new pattern of high‐quality agricultural development in the Loess Plateau.
Design and selection of carbon quota mechanisms from the perspective of carbon trading
Authors: Yu Xiaodong , Sun Fangcheng , Zhao Hongmei , Dai Jiahong , Shu Yuxin , Chen Xin 
Published: August 2023

AbstractThe research shows that when the initial carbon emission per unit product and the emission reduction cost coefficient achieve a certain combination range, the two carbon quota mechanisms will be effective, and its feasible range will be larger. Further, compared with the carbon quota mechanism based on output, manufacturers and retailers will always increase the sales price and wholesale price of products under the carbon quota mechanism based on emission reduction technology but will reduce the emission reduction per unit product. The government will also reduce its total carbon quota under the carbon quota mechanism based on emission reduction technology.