bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring Emerging Contaminants in Soil and Household Dust Samples by Non-Targeted Analysis in the Greater Miami Area, Florida
Authors: Dias Cappelini Luciana Teresa , Ogunbiyi Olutobi Daniel , Guimarães Ferreira Vinícius , Cuchimaque Lugo Carolina , Perez Monica Beatriz , Monem Mymuna , George Florence , Gardinali Piero , Bagner Daniel M , Quinete Natalia 
Published: February 2025

Abstract

Background
Emerging organic contaminants are increasingly present in the environment, with several pollution sources. Soil and household dust are critical pathways for human exposure, posing significant health risks, especially for vulnerable children.

Objective
The objective of this study was to identify and characterize the presence of emerging contaminants in soil and house dust samples in Miami-Dade and Broward counties, Florida, evaluating how seasonal, socioeconomic, and geographic factors influence the distribution of these pollutants.

Methods
Soil and house dust samples were collected from 49 families twice a year between May 2022 and February 2024. Samples were processed by accelerated solvent extraction (ASE) and analyzed by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Chemical identification was performed using Compound Discoverer software.

Results
The predominant compounds in soil were personal care products (PCP)/surfactants, industrial products, and pesticides in the dry season, while pharmaceuticals were found in higher abundance in the rainy season. The most abundant compounds in household dust were pharmaceuticals, industrial products and PCP/surfactants in the dry season, while pesticides stood out in the rainy season. Geographically, the central Miami region presented a wider diversity of contaminants in dust and more PCP/surfactants in soil, while the northern region presented greater contamination by pharmaceuticals and industrial products in soil and more surfactants in dust. Overall, lower-income regions showed greater diversity and abundance of pollutants in dust and soil.

Conclusion
These results suggest that the distribution of organic pollutants in soil and house dust is influenced by seasonal, socioeconomic, and geographic factors. These differences highlight the need for adaptive environmental policies and integrated strategies to mitigate the risks associated with exposure to these pollutants in urban environments, protecting public health.

Highlights
Seasonal variations significantly influence the distribution of emerging contaminants in soil and household dust. Socioeconomic and geographic factors contribute to distinct contamination patterns across Miami-Dade and Broward.
Thymic stromal lymphopoietin contributes to endometriotic lesion proliferation and disease-associated inflammation
Authors: Aleksieva Stanimira , Lingegowda Harshavardhan , Sisnett Danielle J , McCallion Alison , Zutautas Katherine B , Vo Dan Hoang Nguyet , Childs Timothy , Lessey Bruce , Tayade Chandrakant 
Published: February 2025

Abstract
Endometriosis is a chronic disorder in which endometrial-like tissue presents outside the uterus. Patients with endometriosis have been shown to exhibit aberrant immune responses within the lesion microenvironment and in circulation which contribute to the development of endometriosis. Thymic stromal lymphopoietin (TSLP) is an alarmin involved in cell proliferation and the induction of T helper 2 (Th2) inflammation in various diseases, such as asthma, atopic dermatitis, and pancreatic and breast cancer. Recent studies have detected TSLP within endometriotic lesions and shown that its concentrations are elevated in the peritoneal fluid of patients compared with control subjects. However, its role in disease pathophysiology remains unclear. Here, we compared TSLP messenger RNA and protein expression between patient eutopic endometrium, endometriotic lesions, and control endometrial samples. We also assessed its effect on the proliferation and apoptosis of human endometriosis-representative cell lines, as well as on lesion development and inflammation in a mouse model of the disease. We demonstrated that TSLP expression was elevated in the stroma of patient endometriotic lesions compared with control endometrial samples. In cell lines, TSLP treatment reduced the apoptosis of endometrial stromal cells and promoted the proliferation of THP-1 cells. In mice induced with endometriosis, TSLP treatment induced a Th2 immune response within the lesion microenvironment, and led to TSLP receptor modulation in macrophages, dendritic cells, and CD4+ T cells. Furthermore, treatment increased murine endometriotic lesion proliferation. Overall, these results suggest that TSLP modulates the endometriotic lesion microenvironment and promotes a Th2 immune response that could support lesion development.
Probabilistic consequence relations
Authors: Égré Paul , Ripley Ellie 
Published: February 2025

Abstract
This paper investigates logical consequence defined in terms of probability distributions, for a classical propositional language using a standard notion of probability. We examine three distinct probabilistic consequence notions, which we call material consequence, preservation consequence and symmetric consequence. While material consequence is fully classical for any threshold, preservation consequence and symmetric consequence are subclassical, with only symmetric consequence gradually approaching classical logic at the limit threshold equal to 1. Our results extend earlier results obtained by J. Paris in a $\text{Set-Fmla}$ setting to the Set-Set setting, and consider open thresholds beside closed ones. In the Set-Set setting, in particular, they reveal that probability 1 preservation does not yield classical logic, but supervaluationism, and conversely positive probability preservation yields subvaluationism.
Repeatable selection on large ancestry blocks in an avian hybrid zone
Authors: Blain Stephanie A , Justen Hannah C , Langdon Quinn K , Delmore Kira E 
Published: February 2025

Abstract
Hybrid zones create natural tests of genetic incompatibilities by combining loci from two species in the same genetic background in the wild, making them useful for identifying loci involved in both intrinsic and ecological (extrinsic) isolation. Two Swainson’s thrush subspecies form a hybrid zone in western North America. These coastal and inland subspecies exhibit dramatic differences in migration routes; their hybrids exhibit poor migratory survival, suggesting that ecological incompatibilities maintain this zone. We used a panel of ancestry informative markers to identify repeated patterns of selection and introgression across four hybrid populations that span the entire length of the Swainson’s thrush hybrid zone. Two repeatable patterns consistent with selection against incompatibilities – steep genomic clines and few transitions between ancestry states – were found in large genetic blocks on chromosomes 1 and 5. The block on chromosome 1 showed evidence for inland subspecies introgression while the block on chromosome 5 exhibited coastal subspecies introgression. Some regions previously associated with migratory phenotypes, including migratory orientation, or exhibiting misexpression between the subspecies exhibited signatures of selection in the hybrid zone. Both selection and introgression across the genome were shaped by genomic structural features and evolutionary history, with stronger selection and reduced introgression in regions of low recombination, high subspecies differentiation, positive selection within the subspecies, and on macrochromosomes. Cumulatively, these results suggest that linkage among loci interacts with divergent selection and past divergent evolution between species to strengthen barriers to gene flow within hybrid zones.
Efficacy of Dietary Supplementation in the Relief of Inflammatory Bowel Disease: A Systematic Review of Animal Studies
Authors: Mulinari Turin de Oliveira Natalia , Schiebel Carolina Silva , Sauruk da Silva Karien , de Mello Braga Lara Luisa Valerio , Bach Camila , Maria-Ferreira Daniele 
Published: February 2025

Abstract

Context
Supplementation with dietary components is a promising approach for the treatment of inflammatory bowel disease (IBD).

Objective
The aim was to examine the effects of dietary supplements on experimental animal models of IBD.

Data Sources
Articles were selected from 2016 to 2021 and from specific databases (PubMed, Embase, and Scopus).

Data Extraction
Forty-nine studies were analyzed.

Data Analysis
Of the 49 studies, 8 investigated supplementation with oils/polyunsaturated fatty acids, 5 with flavones, 5 with prebiotics and probiotics, 6 with amino acids, 4 with fruits, 4 with vegetables, 2 with minerals, 2 with vitamins, 3 with plants, 2 with polyphenols, and 8 from various sources. Polyunsaturated fatty acids, flavones, prebiotics, and probiotics are among the most extensively studied compounds. Protection is associated with reducing inflammation and oxidative stress, protecting the epithelial barrier and altering the microbiota; however, more rigorous protocols are needed to definitively confirm their protective effects and enable translational research. Fruits, vegetables, plant compounds, minerals, vitamins, and polyphenols, on the other hand, should be studied further and deserve more attention in research.

Conclusion
The results included here support further research into the beneficial effects of supplementation in IBD. Some studies are more advanced and have presented more elaborate protocols, while others still require an increase in knowledge. The identification of dietary supplements that can improve the course of IBD could have an important and lasting impact on the treatment of IBD.

Systematic Review Registration
PROSPERO registration no. CRD42022295260.
Metformin treatment and Immune Reconstitution in People Living with HIV and Type 2 Diabetes: A Matched Retrospective Study
Authors: Bäckdahl Tintin , Hedberg Pontus , Vesterbacka Jan , Carlander Christina , Sönnerborg Anders , Nowak Piotr 
Published: February 2025

Abstract

Background
Despite effective antiretroviral treatment (ART), HIV infection is associated with immune dysfunction and inflammation. Metformin has shown beneficial immunological and anti-inflammatory effects, including in people living with HIV (PLWH). We studied the potential association between metformin treatment and immune reconstitution in PLWH.

Methods
We conducted a retrospective cohort study set in Stockholm, Sweden. PLWH with T2DM that initiated metformin treatment after at least 2 years on effective ART (exposed individuals) and metformin-naïve PLWH (controls) were matched in a 1:1 ratio based on age, sex, baseline immune status and duration of ART. Outcomes included mean values of CD4 cell counts and CD4/CD8 ratios from 1.5 year to 3.5 years after compared with 2 years before the exposed individual started metformin treatment (index date).

Results
Among 1,332 PLWH, 43 metformin exposed individuals (median age 48 years, 11 years since start of ART) with T2DM and 43 non-diabetic controls (median age 47 years, 11 years since start of ART) were included in the matched analyses. The median (interquartile range) change in CD4 T cell count was 35 (-21 to 125) cells/μL among exposed individuals and 48 (-18 to 100) cells/μL among controls (P=0.96). The corresponding numbers were 0.10 (0.03 to 0.20) and 0.08 (0.02 to 0.16) for CD4/CD8 ratio (P=0.18). No differences were observed in subgroup analyses of PLWH with low CD4 T cell counts and CD4/CD8 ratios, respectively.

Conclusions
No significant differences in immune reconstitution were observed between metformin treated individuals and matched controls over the 2-year follow-up period.
Atmospheric sulfate aerosol formation enhanced by interfacial anions
Authors: Wang Gehui , Zhang Si , Wu Can , Zhu Tong , Xu Xinbei , Ge Shuangshuang , Sun Haitao , Sun Zhenrong , Wang Jiaxin , Ji Yuemeng , Gao Jian , Ren Yanqin , Li Hong , Zhang Fang , Wang Yuan , Seinfeld John H 
Published: February 2025

Abstract
Heterogeneous oxidation of SO2 by NO2 on aerosols has recently been found to be one of the major formation pathways of sulfate in polluted troposphere, but the chemical mechanisms and kinetics remain uncertain. By combining lab experiments, theoretical chemistry calculations and field measurements, here we show that the SO2 oxidation by NO2 is critically dependent on anions at the air-aerosol aqueous interface. The reaction rate of NO2 with HSO3- (1.1×108–1.6×109 M-1s-1) is more than four orders of magnitude larger than the traditionally held value for the bulk phase due to the abundant occurrence of chloride, nitrate and carboxylic anions at the air-aqueous interface, which remarkably accelerates sulfate formation during China haze periods by enhancing the uptake of NO2 through interfacial electrostatic attraction. Atmospheric models not accounting for this aerosol interfacial process likely produce major misrepresentations of tropospheric sulfate aerosols under polluted conditions.
Remote/hybrid work in flux: work-place/preference mismatch and adaptations
Authors: Fan Wen , Moen Phyllis 
Published: February 2025

Abstract
The COVID-19 pandemic led to an unprecedented employer-driven shift to remote/hybrid work for those whose jobs allow it, but then came retrenchments, forging disjunctures between where one works (remote/hybrid or in-person) and individual preferences, which we term work-place mismatch. We draw on a combined worker power, employer biases, and adaptive strategy theoretical framing to investigate work-place mismatch in light of remarkable pandemic-precipitated shifts in place of work, opening up possibilities (and preferences) for remote/hybrid arrangements. In addition to examining inequities in work-place mismatch, we theorize employees’ possible adaptive strategies when confronting such mismatch—shifting where they work, changing their locational preferences, or intending to leave or actually leaving their employer. Using a nationally representative four-wave panel (October 2020–April 2022) of US employees who worked fully or partially remotely during the pandemic, we find that work-place mismatch is widespread, especially among those returning to on-site work. Hispanics, Black men, and those lacking a college degree are most likely to experience unfulfilled interest (mismatch) in remote work. Structurally disadvantaged mismatched workers also experience constrained strategies—less apt to change their work location or quit relative to white or college-educated workers.
Alternative Splicing in Embryo Implantation
Authors: Yu Luping , Zhu Sijing , Bao Haili , Kong Shuangbo 
Published: February 2025

Abstract
Alternative splicing (AS) is a crucial process that produces functionally distinct proteins from a single gene, depending on the developmental or physiological state of cells in multicellular organisms. It plays a significant role in cellular proliferation, survival, and differentiation, including embryonic development, spermatogenesis, and a broad spectrum of diseases. However, the precise involvement of AS in embryo implantation is still unclear. In this review, we summarize the potential roles of AS in regulating mesenchymal-epithelial transitions during embryo implantation, specifically in epithelium regeneration and decidualization initiation via the mesenchymal-epithelial transformation process. Overall, this review emphasizes the impact of AS and splicing variants on embryo implantation and offers novel insights into the potential application of alternative splicing in the treatment of female infertility.
Myopia in Houston optometry graduates from 2013 to 2023
Authors: Lal Barsha , Joseph Joshua , Cantrell Amy , Cheng Han , Ostrin Lisa A. 
Published: February 2025

SIGNIFICANCE
Adult onset and progression of myopia are not well understood. It is of interest to better characterize myopia progression in young adults, who are frequently subjected to risk factors, such as intense near-work demands.

PURPOSE
This study aimed to assess the prevalence and progression of myopia and other refractive errors in optometry students in the United States.

METHODS
This study was a retrospective chart review of electronic medical records of students enrolled in the optometry program at the University of Houston College of Optometry who graduated between 2013 and 2023. For each student, refractive error was noted from the medical record for eye examinations during their time as an optometry student. Exclusion criteria were ocular disease, myopia control treatment, or refractive surgery. Prevalences of hyperopia (≥+ 0.50 D), emmetropia (>−0.50 to <+0.50 D), myopia (≤−0.50 D), astigmatism (>0.50 D), and anisometropia (≥1.0 D) were determined from spherical equivalent refraction (SER) of the right eye. Absolute and annualized differences in SER were calculated between visits.

RESULTS
Records for 1071 students were reviewed, and 961 were included. Prevalences were 80.7% for myopia, 14.9% for emmetropia, and 4.4% for hyperopia. Additionally, 38.4% had astigmatism, and 16.1% had anisometropia. Students with one follow-up exam (n = 639) showed a significant negative change in SER of −0.05 ± 0.38 D over an average follow-up period of 1.60 ± 0.61 years (p=0.001). Myopia onset was observed in 15.7% of emmetropes at baseline. Greater negative SER change was associated with greater follow-up duration and younger age. Hyperopes and emmetropes did not demonstrate significant changes in SER. An annualized negative SER change of ≥−0.25 D was noted in 20% of the 639 students, of which 5.5% showed ≥−0.50 D.

CONCLUSIONS
Findings demonstrate a high prevalence of myopia among optometry students. A small but statistically significant myopic change in refraction was observed. These findings may implicate a role of education and near work in myopia.
Psycho-oncology clinicians' perceptions of blended psychological therapy for the treatment of anxiety and depression in patients with cancer: a qualitative interview study
Authors: Nunes-Zlotkowski Kelly F. , Shepherd Heather L. , Butow Phyllis , Beatty Lisa , Shaw Joanne M. 
Published: February 2025

Abstract

Background:
Despite effective cancer-specific interventions for depression and anxiety, treatment uptake is low. Blended psychological therapy (BT) may improve access to treatment and enhance uptake and adherence as it combines patient-driven, online therapy with therapist-facilitated sessions. Research supports the acceptability and feasibility of BT in a noncancer context, but evidence in psycho-oncology is limited. The aim of this study was to explore psycho-oncology stakeholders' (service managers, psychologists) views on the feasibility and acceptability of BT and potential implementation of BT models into psycho-oncology care in Australia.

Method:
Qualitative, semistructured telephone interviews were conducted with psychologists working clinically with patients with cancer and psycho-oncology service managers. Interviews were analyzed using a framework analysis approach and mapped against the Consolidated Framework for Implementation Research domains.

Results:
Twenty-two clinicians (17 psychologists, 5 managers) were interviewed. An overarching theme of trust was identified, underpinned by 3 themes: (i) influence of system factors on readiness to change; (ii) treatment engagement; (iii) autonomy and empowerment. Participants shared concerns about service over-reliance on the BT digital component but also recognized its potential in expanding service reach. The use of digital technology was perceived as a barrier to patient engagement but also trusted for providing flexible access. In addition, participants voiced concerns regarding duty-of-care and lack of autonomy to deliver therapy but noted that BT could optimize clinician time and resources.

Conclusion:
Overall, BT was feasible and acceptable. Future research will incorporate stakeholders' preferences for and evaluation of a cancer-specific anxiety and depression BT intervention.
Longitudinal remote sleep and cognitive research in older adults with mild cognitive impairment and dementia: a prospective feasibility cohort study
Authors: Gabb Victoria Grace , Blackman Jonathan , Morrison Hamish Duncan , Li Haoxuan , Kendrick Adrian , Turner Nicholas , Greenwood Rosemary , Biswas Bijetri , Coulthard Elizabeth 
Published: February 2025

STRUCTURED ABSTRACTINTRODUCTIONWe investigated the feasibility of remote longitudinal research using wearable devices and smartphone applications to record sleep and cognition in older adults with mild cognitive impairment (MCI) or dementia.METHODSOlder adults with MCI or dementia due to Alzheimer’s disease (AD) or Lewy body disease (LBD) and cognitively healthy participants completed at-home sleep and circadian monitoring (digital sleep diaries, actigraphy, wearable sleep electroencephalography (EEG), saliva samples) and digital cognitive assessments for 8 weeks. Feasibility outcomes included recruitment, retention, and data completeness.RESULTS41 participants consented (10 AD, 11 LBD, and 20 controls) and 40 completed the 8-week study. Data completeness for sleep EEG was 91% and ranged from 79% to 97% for all remote tasks. 12/40 (30%) participants reported receiving external support with completing study tasks.DISCUSSIONLongitudinal multimodal sleep and cognitive profiling using novel technology is feasible in older adults with MCI and dementia and healthy older adults.