bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the spectrum of genetic variations in young cancer patients presenting to the tertiary cancer centre
Authors: Vutukuru Anuradha , Suresh A. V. S. , Sharma Rakesh , Nageshwar Rao Suragani , Mithila K. B. , Sreedhar Vijaya , V. Sailaja 
Published: September 2023

Background: Aim of the study was to evaluate the spectrum of genetic variations in young cancer patients presenting to the tertiary cancer center
Methods: All newly diagnosed patients with cancer presenting to medical oncology OPD at continental hospitals between November 2021 till July 2023 were analyzed. Multigene panel testing (56 genes) by next-generation sequencing was performed for all patients. Demographics and clinical characters were represented using descriptive statistics. The Chi-square test was used to compare the cohorts of Mutations vs. non mutations.
Results: A total of 130 cancer patients were screened and 70 were recruited in the study, which had complete set of clinical details available. Median age of Cohort is 41.9±6.6 years and for females it is 43.6±6.8 years and males it is 40.5±7.3, with males presenting at approximately 3 years earlier than females (p=0.12), which is not statistically significant. Male female ratio is 1.2:1, which is much less compared to Globocon statistics of cancer in India. A total of 47% (33/70) subjects had some mutation and approximately 16% (11/70) had variance of unknown significance and 32% (22/70) patients had pathogenic variants. The commonest cancer is breast followed by colon and prostate.
Conclusions: Younger cancer patients presenting with atypical symptoms harbor more frequent germ line mutations, than expected. In view of the low cost, standardized and wide availability of the germ line analysis, it’s preferred to offer the test, wherever clinically relevant. This can help for better education, screening and early intervention, that ultimately help improve the cancer statistics in healthier directions.
The Pareto Distribution of World’s GDP
Authors: Tomić Z P 
Published: September 2023

The problem of wealth distribution has gathered the attention of researchers for many years. In their work, the researchers are mainly engaged in the issue of distribution of wealth between individuals by analyzing empirical results at the country level, or specific lists that particular organization form like the Forbes list. Research are also increasingly directed toward the analysis of new models such as Boltzmann Gibbs or application of Gama function that describes this distribution. An interesting issue is the analysis of the distribution of wealth among the countries themselves. In these works, the value of GDP is used as the wealth that country has. In this article, the author dealt with the analysis of the distribution of GDP between countries at the global level. Analysis were performed using the Pareto distribution model of wealth distribution and GINI coefficient based on the data of the value of GDP for countries from IMF estimation. The analysis was conducted for the period from 1980 to the present, as well as analysis of data provided by IMF estimates for the value of GDP by 2022. The goal is to determine the degree of uneven distribution between the countries themselves in the world, analyzing the dynamics of change in the degree of unevenness and an analysis of the degree of unevenness in the future based on forecasts of the IMF on the values of countries GDP. The author also wanted to test if Pareto's 80/20 rule applies when it comes to the distribution of GDP at world level.

Keywords: GDP, distribution of wealth, IMF, Pareto distribution, GINI coefficient
An Analysis of Critical Variables Affecting Working Capital in Infrastructure Projects
Authors: Kantianis D D , Liapis K J 
Published: September 2023

The research aims at exploring the critical variables that affect public works contractors’ working capital in the delivery of infrastructure projects. Effective financial management has long been recognized as the ‘lifeblood’ of construction contractors, especially during economic periods of recession. The main reason for insolvency in the built environment is the lack of working capital to support contractors’ site operations. Therefore, it is vital to accurately predict the project working capital requirements at the pre-tender stage and closely monitor project cash-flow during the physical production process. The proposed methodology entails the development of a cash-flow/ working capital calculation process based on spreadsheet modelling and the Gantt chart for the derivation of project disbursements S-curves, revenue step function curves, and maximum/net cash-flow profiles. The model is implemented to a recently delivered typical infrastructure project – the construction of a new peripheral highway reinforced concrete bridge – and a sensitivity analysis is conducted to reach useful conclusions concerning the significance in infrastructure working capital of the following variables examined: the retention percentage, the ‘front-end rate loading’ by the contractor, and the premium advance incentive by the owner. The lowest maximum working capital requirement results from the provision of an advance mobilization payment by the owner to the contractor at project start-up and the selection of the latest start times site work execution program. The herein presented study is expected to assist both researchers and practitioners operating within the public construction sector in decision-making towards more effective financial management of infrastructure projects.

Keywords: infrastructure projects, public works contractors, cash-flow management, working capital, Gantt chart, S-curve
E-shopping Across EU – Why Some Individuals Refuse to Adopt It?
Authors: Božić L , Botrić V 
Published: September 2023

Despite many advantages of e-commerce for both firms and buyers, it is still not equally adopted by customers in all European Union countries. According to Digital Scoreboard in countries such as United Kingdom and Denmark, nearly 90% of Internet users shop online. On the other hand, in Romania and Bulgaria, not even one-third of the Internet users buy goods and services online. Diffusion of e-shopping clearly has different pace across EU. In this article, we focus on individuals who refuse to purchase over Internet and aim to explore reasons for their behavior. To do so, we rely on Community Statistics on Information Society (CSIS) microdata for the year 2015. Individuals who report ordering and buying over the Internet more than one year ago and those who never engaged in online shopping were asked about reasons for not buying online. Potential reasons include lack of skills, privacy and security concerns, delivery concerns and problems, not having payment cards as well as habit, loyalty and preference of shopping in stores. The focus of this article is on comparison of reasons for not shopping online of individuals in EU countries that lead in adoption of e-shopping with laggard countries. We first analyze the prevalence of reasons for not buying online and compare countries in that respect. Among individuals who did not adopt e-shopping, there are those who have tried it at one point in time and did not continue to use it frequently and those who actually never engaged in buying over Internet. Both have certain reasons and constrains that prevent them from adopting this form of shopping. The analysis is followed by identification of reasons that significantly affect probability of trying online shopping, if not adopting it fully. It can be assumed that gaining true experience might contribute to increase in adoption of e-shopping among individuals. This is even more important for countries that still lag behind not just in buying online but in overall digital performance.

Keywords: e-shopping, adoption, customers, European Union
Ankara Eğitim ve Araştırma Hastanesi aile hekimliği polikliniklerinde hasta memnuniyetinin değerlendirilmesi
Authors: KALENDER KARA Merve , ARSLAN İsmail , ÇAKIT Mehmet Onat , ÇELİK Mustafa 
Published: September 2023

Amaç: Hasta memnuniyet düzeylerinin belirlenmesi ve etkileyen faktörlerin ortaya konması ile daha nitelikli sağlık hizmet sunulması sağlanabilir. Bu çalışmada, aile hekimliği polikliniklerimizdeki hasta memnuniyetini saptamak amaçlanmıştır.
Gereç ve Yöntemler: 18 yaş üstü 270 gönüllü erişkin hasta çalışmaya dâhil edildi. Hastaların sosyodemografik özelliklerini, alışkanlık durumlarını sorgulayan bir anket ve Ayaktan Hasta Memnuniyet Ölçeği katılımcılara yüz yüze görüşme esnasında uygulandı.
Bulgular: Katılımcıların 78 (%28.88)’u erkek, 192 (%71.11)’i kadın ve yaş ortalaması 41.72±15 yıl idi. Katılımcıların %94.07’inin aile hekimliği polikliniğine tekrar gelmek istediği, %95.92’sinin tavsiye ettiği gözlenmiştir. Tüm katılımcıların ölçek ortalama puanı 111.25±27.67 olarak bulundu. Katılımcıların ölçek toplam ve alt boyut puanları ile yaş, cinsiyet, medeni durum arasında istatistiksel olarak anlamlı bir farklılık saptanmadı (p>0.05). Katılımcıların eğitim durumu lise altı olanların “Genel memnuniyet” puanları daha yüksek bulundu (p=0.044). Katılımcıların mesleki durumu çalışmıyor olanların ölçek toplam puanları daha yüksek bulundu (p=0.035).
Sonuç: Hasta memnuniyetinin eğitim düzeyi, meslek grubu gibi sosyodemografik verilere göre değiştiği görülmüştür. Hasta memnuniyetini olumlu etkileyen faktörlerin doğru bir hasta-hekim ilişkisi ve iyi iletişim becerileri olduğunu düşünmekteyiz.
Sexual Violence in the Islamic Law Perspective: Aceh Islamic Law and Local Wisdom Approach
Authors: Danial Danial , Yoesoef Yoesrizal M. , M Nur Sari Dewi. 
Published: September 2023

The study aims to examine the integration of religious values, Aceh culture, and global issues, which form the Sexual Violence Crime Law (UU-TPKS). This article is a qualitative study with a descriptive approach where the primary data were obtained through interview and group discussion. The study used relevant sources from books, journals, and articles related to the chosen theme as the secondary data. This study shows that integration of religious values into the Sexual Violence Crime Law (UU-TPKS) is necessary because Indonesian law must be based on the Pancasila philosophy as a result of the translation into Islamic values. It further shows that religious, cultural, and global values embodied in that law are the values of tauhid, justice, freedom, kindness, cooperation, equality, and tolerance. The state must measurably implement all values and derive them into laws and regulations. The study also reveals that such an integration reflects the integration of religious principle and values and local wisdom described in various meanings and symbols.
Keywords: Islamic Law, Sexual Violence, Local Wisdom, Aceh
Formation of professional competence for future social educators based on an integrated approach
Authors: Utegenova Meruyert , Sholpankulova Gulnar , Shavaliyeva Zulfiya , Zhmailo Tatyana , Yerepbayev Nurlan 
Published: September 2023

The objective of this study is to assess the efficacy of a comprehensive strategy for developing the professional abilities of social educators. Additionally, it seeks to identify the problems encountered by high schools in this regard and examine the process of cultivating professional competencies. The research comprised a sample of 253 individuals from L. Gumilyov Eurasian National University, located in Astana, Kazakhsta. The study compares the diagnostic results on a quantitative and qualitative level. The assessment standards of Fisher and the descriptive statistics were acquired. The study's data was gathered by requesting questions from teachers and students, testing, interviews, and evaluations from experts who fit this profile. The findings indicated that future social educators will have problems with their lack of high-level professional competence. Additionally, the majority of employers have requirements that are related to how well students develop their skills as well as their motivation to engage in extracurricular activities, work on themselves, and engage in future professional endeavors. The study revealed that employing an integrated strategy for the training of prospective social teachers yielded the most significant impact on the development of their professional abilities. The study's findings can be used to improve vocational training for social educators.
SISTEM PENENTUAN STAF TERBAIK BADAN EKSEKUTIF MAHASISWA PRODI PENDIDIKAN TEKNIK INFORMATIKA DAN KOMPUTER UNIVERSITAS NEGERI JAKARTA (BEMP PTIK UNJ)
Authors: Adam Rifki Lusandi  , Hamidillah Ajie  , Murien Nugraheni  
Published: September 2023

Pengelolaan staf dari suatu organisasi sangat mempengaruhi banyak aspek penentu keberhasilan program kerja dari suatu organisasi. BEMP PTIK UNJ melakukan staf terbaik untuk memacu semangat stafnya untuk meningkatkan kinerjanya. Tetapi dalam pelaksanaannya BEMP PTIK UNJ mengalami masalah, permasalahan yang terjadi yaitu mengalami kesulitan dalam menentukan staf terbaik BEMP PTIK UNJ dengan waktu yang singkat. Akibatnya BPH BEMP PTIK UNJ memiliki kendala terhadap penentuan staf terbaik dan sistem pendukung keputusan yang dapat membantu menentukan staf terbaik sesuai dengan kriteria yang sudah ditentukan yaitu terdiri dari empat kriteria yaitu kehadiran diseluruh rangkaian acara, Aktif diseluruh rangkaian acara, Tanggung Jawab, dan Menjadi Badan Pengurus Kegiatan. Tujuan dari penelitian ini adalah menghasilkan sebuah web sistem pendukung keputusan yang digunakan untuk sistem penentuan staf terbaik BEMP PTIK UNJ yang membantu untuk pengambilan keputusan yang tepat, cepat dan mengurangi kesalahan dalam menentukan staf terbaik BEMP PTIK UNJ. Dalam pengembangan web Sistem Penentuan Staf Terbaik BEMP PTIK UNJ ini menggunakan metode waterfall dengan melakukan wawancara dan studi literatur. Wawancara menghasilkan daftar kebutuhan fungsional dan selanjutnya dibuat rancangan Entity Relationship Diagram (ERD), Data Flow Diagram (DFD), dan Mockup web. Kemudian implementasi dilakukan melalui kode program dengan menggunakan bahasa PHP dengan framework Codeigniter. Penelitian ini dilakukan untuk melakukan pemilihan staf terbaik pada BEMP PTIK UNJ dengan menggunakan metode Simple Additive Weighting. Sample didapatkan dari data seluruh staf BEMP PTIK UNJ 2019 serta pengujian dilakukan dengan black box testing dan user acceptance testing. Sistem ini berhasil menyelesaikan beberapa permasalahan yang ada dalam menentukan staf terbaik BEMP PTIK UNJ dengan cara menggunakan sistem pendukung keputusan berbasis website dengan menggunakan metode pengembangan perangkat lunak waterfall dan metode algoritma perhitungan Simple Additive Weighting sebagai perhitungan dalam menentukan staf terbaik BEMP PTIK UNJ.
The Dying Art of Minifrac Analysis: How an Over-Reliance on Expert Computer Systems Can Turn Perfectly Good Data into Misleading Results
Authors: Martin A. N. , Franquet Javier 
Published: September 2023

Abstract
Minifrac analysis used to be an essential skill for a hydraulic fracturing engineer. In fact, the ability to quickly and effectively gather, merge, filter and analyse the step rate test, breakdown and minifrac data, followed by an efficient redesign of the main treatment (often under extreme pressure), used to be a "right of passage" for many practitioners. However, as in many areas of life, the last 10 years has seen an ever-increasing reliance on so-called expert systems and the easy option is increasingly for engineers to plug in the data and watch the results come out. Often - and crucially – with little application of sound engineering judgement, or reference to independent sources of data.
We must always remember that we are not dealing with exact systems. Our data set may be faulty (especially with regard to reservoir properties) and the simulator may not be reliable. The engineer must have an appreciation of what is realistic and what is not. The reality is that even though we may have precise analytical models of hydraulic fracture propagation, the formation itself is not precise and does not readily lend itself to analytical methods. There is both art and science to fracture engineering, but the art cannot be applied without first having a thorough understanding of the science.
To illustrate this, minifrac, DFIT and straddle packer openhole microfrac tests are compared to get insightful information on fracture closure pressure identification. Typically, large injection volumes produce enough poroelastic effects to disturb the horizontal stress around the wellbore, whilst a high injection rate tends to increase the formation breakdown pressure. In other cases, DFIT tests produce enlarged net-pressure values, as compared with Minifrac and microfrac tests conducted on the same well.
This paper will seek to outline several critical errors of judgement that are regrettably now quite common in this aspect of fracture engineering. This will be illustrated with case histories. Following this, the authors will attempt to provide some best practices to help ensure that these basic errors can be eliminated
Revolutionizing Oil Production: The Success of Enhanced Hydraulic Fracturing Techniques in Tight Oil Field Reservoirs
Authors: Pasumarthi R. , Koduru A. , Meena H. , M Patil R. , Govind Raj P. 
Published: September 2023

Abstract
This paper focuses on the potential of enhanced Hydraulic Fracturing (HF) techniques as a means to unlock the full potential of tight oil field reservoirs. The field X, discovered in 2010 in the KG Basin on-land, in Southern India, has presented a unique challenge for oil extraction due to its highly heterogeneous tight sand composition, with highly varying porosity and permeability, and high bottom hole temperatures up to 325-degF. Traditional methods of extraction have been financially unviable, making it necessary to find alternative methods to increase production.
Prior to 2017, several HF operations were carried out in the field X, but those attempts were unsuccessful due to limited understanding of the reservoir. To address these challenges, the reservoir was studied using several fracture diagnostic tests and a suitable and efficient fracturing fluid system was designed based on simple borate crosslinking to handle the high bottom hole temperature of up to 325-degF. Enhanced custom HF techniques were carried out on 10 wells with a total of 13 stages, reaching 330,700lbs per stage. The design models were optimized using HF simulators.
The heterogeneity of the field X, in the selected candidate wells for HF, presented challenges in the form of varying leak-off characteristics (with fluid efficiency ranging from 32-83%), tortuosity effects, permeability (ranging from 0.01-2mD) and several other reservoir attributes. However, through meticulous optimization of the fracturing process, a remarkable 8-fold increase in oil production was achieved, elevating production from 176 bopd (pre-HF campaign) to 1575 bopd (post-HF campaign). This outstanding success not only demonstrates the immense potential of enhanced HF but also serves as a blueprint for fully unlocking the productivity of tight oil field reservoirs like field X.
Frac Growth Diagnostic Analysis Using Fiber and Sealed Well Integrated Data
Authors: Qasim Muhammad , Rueda Jose , Valbuena Jose , Zakary Maram 
Published: September 2023

Abstract
A trial was executed in unconventional field of Saudi Aramco to characterize the hydraulic frac growth for two different state of the art frac designs by monitoring acoustic and pressure responses in offset wells using fiber optics & sealed wellbore pressure data, respectively. Hydraulic frac characterization helped in evaluating the frac designs, cluster efficiency, parent-child interaction, and frac-hits which will help in the selection of the frac design for the development phase.
Two north wells of a single pad were fractured with design-A (less intense design), while two south wells of the same pad were fractured with design-B (highly intense with engineering limited entry). These north and south wells were monitored through their offset wells in different pads by deploying fiber and pressure gauges in the sealed wellbores. Fiber helped identifying fracture corridors, previous stage reactivation, frac-hit time and intensity, and volume to first response (VFR). While sealed well pressure data helped identifying frac-hit time and intensity, and volume to first response (VFR). volume to first response (VFR) at the monitor well is an inversely proportional indicator of frac half length. Fracture corridor from fiber data at monitor well was used to estimate the frac corridor widths for all the stages in addition to the magnitude of pressure/strain changes observed due to frac-hits to estimate the intensity of frac-hits. Combining fiber with a sealed wellbore helped in establishing the baseline for sealed wellbore pressure observation and its interpretation for future wells.
Data from both sources was captured successfully. Frac-hits identified by fiber were further endorsed by sealed wellbore pressure data along with the frac-hit time, with an excellent correlation of R2-0.93. Results of this trial showed two distinct responses for two different designs (design-A and design-B). High volume to first response (VFR) in design-A compared to design-B initially suggested a more heterogeneous fracture network being created in design-A. However, frac corridors from fiber data showed that the majority of design-A frac corridors were reactivating previous stages and resulting in high VFRs. On the other hand, design-B had a more effective fracture corridor with significantly less overlap to the previous stages, resulting in low VFRs. Moreover, frac-hits were more intense and contained in design-B compared to design-A. This paper will present the impact of these two different designs on production.
Lessons learned, interpretation best practices for both fiber and sealed-wellbore monitoring pressure, and the correlation among major KPIs (being estimated from the acquired data) will be presented in this article for cases where both technologies were run into a single wellbore. This helped better characterize the fracture growth and will help in future job planning and interpretation of the data for frac characterization.
Research of Operational Dynamics of a Well with Two Hydraulic Fractures with Use of Marked Proppant Penetrating into One Productive Formation
Authors: Malyavko Evgeniy , Upadhye Vishwajit , Husein Nadir 
Published: September 2023

Abstract
Use of a marked proppant during hydraulic fracturing allows for evaluation of the well operation during several years without extra expenses. The Paper describes the experience of placement of a polymer-coated marked proppant with different signatures for two hydraulic fracturing operations, penetrating into the top and the bottom of the productive formation by a vertical well. Hydraulic fracturing operation was performed in such a way that the hydraulic fractures made a single fracture, where two signatures of a marked proppant were placed.