bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electric brain potentials evoked by pictures of meaningful activities: a search for “meaning”
Authors: Cruyt Ellen , Criel Yana , De Vriendt Patricia , Vlerick Peter , Calders Patrick , De Pauw Robby , Oostra Kristine , De Letter Miet , de Velde Dominique Van 
Published: July 2023

Abstract

Introduction
Meaningful activities contribute to wellbeing, health, and quality of life. Understanding the brain mechanisms that underlie the attribution of meaning to activities is crucial for further comprehension of human functioning and health.
Method
An explorative electroencephalographic study including thirteen females. A visual paradigm with picture stimuli containing self-selected meaningful activities of the participants was included. The participants scored each activity on meaningfulness based on a VAS-scale. Event-related potentials (ERPs) were studied in five time windows related to the P1-N1-P2 complex, N200, and N400 component. Mean amplitudes and onset latencies were compared between the two conditions using a paired student t-test. A two-way repeated ANOVA was conducted to examine the main and interaction effects of the conditions and topographical region in the N200 and N400 time window. The ERPs were inspected on a subject-level.
Results
No significant difference between the meaningful and non-meaningful condition was found on both amplitudes and onset latencies in the N200 and N400 time window. No interaction effects between topographical region and condition were found for N200 and N400.
Discussion
A first attempt was made to investigate neurophysiological correlates of the cognitive process of attribution of meaning to activities. We could not capture an effect in the N200 or N400 component. We evaluated the new paradigm and suggested other brain registration techniques.
Conclusion
The neurophysiological correlates of the cognitive process of attribution of meaning to activities was investigated. We could not capture an effect in the N200 or N400 component.
Correlation of several forms of folic acid with endometrial cancer: cross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2011-2018
Authors: Zhang Meng , Li Ruiping , Fan Xuefen , Zhang Shan , Liao Lixin , Xu Xin , Guo Yuzhen 
Published: July 2023

Abstract
Objective
Endometrial cancer (EC) is a common malignancy of the female reproductive system and although most patients have a good prognosis, 20–30% of patients with advanced disease have a poor prognosis. There are currently no reliable biomarkers for early diagnosis and effective prognostic improvement of the disease. The aim of this study was to explore the effect of folic acid on the occurrence of EC and its clinical application using the National Health and Nutrition Examination Survey (NHANES) database.
Methods
This study included 8,809 female subjects aged ≥ 20 years in the NHANES database from 2011–2018, including 8,738 non-oncology patients and 71 EC patients. Reduced selection bias using 1:1 propensity score matching (PSM) method. Restricted cubic spline (RCS) was plotted to explore the non-linear relationship between different forms of folic acid and EC.
Result
Using data from the NHANES database from 2011–2018 to assess the association between folic acid and the risk of developing EC. The results of the 1:1 ratio propensity score matching (PSM) showed 68 each for EC patients and non-oncology participants. Total serum folate, 5-methyltetrahydrofolate (5-methylTHF), 5-formyltetrahydrofolate (5-formylTHF), tetrahydrofolate (THF) and 5,10-methylenetetrahydrofolate (5,10-methenylTHF) were significantly correlated with EC (p < 0.05). In addition, the RCS showed a significant non-linear correlation between THF and 5,10-formyl THF and the risk of developing EC.
Conclusion
The results of this study showed that changes in serum total folate, 5-methylTHF, 5-formylTHF, THF and 5,10-methenylTHF were closely related to EC.
Immunotherapies for intrahepatic cholangiocarcinoma: Prognostic model for Overall Survival
Authors: Lv Yinghao , Liu Hu , He Penghui , Xie Sinan , Yin Xiuchun , Cai Yunshi , Wu Hong 
Published: July 2023

Abstract
Objective
Intrahepatic cholangiocarcinoma (ICC) accounts for 20% of liver malignancies with a 5-year survival rate of 35% at best with limited prognostic predictors. Lung Immune Prognostic Index (LIPI) is a novel prognostic factor in pulmonary cancers. In this study, we developed a modified prognostic model from LIPI called intrahepatic immune prognostic index (IIPI) for ICC.
Patients and method:
A retrospectively study was conducted at Liver Transplant Center of West China Hospital between January 2015 and January 2023. Hematological factors and clinical features of ICC patients were collected and analyzed. The area under curve (AUC) and optimal cuff-off of each single hematological factor was calculated.
Results
In this study, derived neurtrophil to lymphocyte ratio (dNLR), arbohydrate antigen199 (CA199) and carcinoembryonic antigen (CEA) have higher AUC values. LIPI was composed of dNLR and was further modified by combing CA199 and CEA, forming the IIPI. The IIPI consists of four grades which are None, Light, Moderate and Severe. Compared to other prognostic factors, IIPI exibited better ability to predict overall survival. The multivariate analysis indicated that cirrhosis, differentiation, hilar invasion and IIPI were independent prognostic factors for ICC patients. An IIPI-based nomogram was also established and could predict the overall survival. In addition, the subgroup analyses based on clinical prognostic factors showed that the IIPI exhibited excellent prognostic influence.
Conclusion
IIPI model is suitable for predicting the prognosis of postoperative ICC patients. Further research is needed to explore the relationship between postoperative recurrence and metastasis of ICC patients and IIPI.
Metagenomic Analysis of Carbohydrate-Active Enzymes and Their Contribution to Marine Sediment Biodiversity
Authors: López-Sánchez Rafael , Rebollar Eria A. , Gutiérrez-Ríos Rosa María , Garciarrubio Alejandro , Juarez Katy , Segovia Lorenzo 
Published: July 2023

Abstract
Marine sediments constitute the world's most substantial long-term carbon repository. The microorganisms dwelling in these sediments mediate the transformation of fixed oceanic carbon, but their contribution to the carbon cycle is not fully understood. Previous culture-independent investigations into sedimentary microorganisms have underscored the significance of carbohydrates in the carbon cycle. In this study, we employ a metagenomic methodology to investigate the distribution and abundance of carbohydrate-active enzymes (CAZymes) in 37 marine sediments. These sediments exhibit varying oxygen availability and were isolated in diverse regions worldwide. Our comparative analysis is based on the metabolic potential for oxygen utilisation, derived from genes present in both oxic and anoxic environments. We found extracellular CAZyme modules targeting the degradation of plant and algal detritus, necromass, and host glycans were more prevalent across all metagenomic samples. The analysis of these results indicates that the oxic / anoxic conditions not only influence the taxonomic composition of the microbial communities, but also affect the occurrence of CAZyme modules involved in the transformation of necromass, algae and plant detritus. To gain insight into the sediment microbial taxa, we reconstructed metagenomic assembly genomes (MAG) and examined the presence of primary extracellular carbohydrate active enzyme (CAZyme) modules. Our findings reveal that the primary CAZyme modules and the CAZyme gene clusters (CGC) discovered in our metagenomes were prevalent in the Bacteroidia, Gammaproteobacteria and Alphaproteobacteria classes. We compared those MAG to MAG from the same classes found in soil, and we found that they were similar, but the soil MAG contained a more abundant and diverse CAZyme content. Furthermore, the data indicate that abundant classes in our metagenomic samples, namely Alphaproteobacteria, Bacteroidia and Gammaproteobacteria, play a pivotal role in carbohydrate transformation within the initial few metres of the sediments.
Data-independent acquisition (DIA) mass spectrometry reveals related proteins involved in the occurrence of early intestinal-type gastric cancer
Authors: Zhang Liangshun , Xu Feng , Lu Hongna , Dong Xianwen , Gao Zhiqiang , Zhao Qiaosu , Weng Ting , Li Hong , Ye Hua 
Published: July 2023

Abstract
Background: The identification of proteins involved in the occurrence of early intestinal-type gastric cancer (EIGC) may provide valuable insights into the pathogenesis of intestinal gastric cancer.
Methods: Data-independent acquisition mass spectroscopy (DIA-MS) was utilized to identify the differential protein between 10 cases of EIGC and atrophic gastritis with intestinal metaplasia (NGC). The expressions of IPO4, TBL1XR1, p62/SQSTM1, PKP3, and CRTAP were verified by immunohistochemistry (IHC) in 20 EIGC samples, 17 gastric low-grade intraepithelial neoplasia (LGIN), and 21 healthy controls. The prognostic values of the five genes were validated in the transcriptome data by survival analysis.
Results: A total of 4,028 proteins were identified using DIA-MS, with fold change> 1.5 times as a significant difference, and a total of 177 different proteins were screened. Among them, 113 proteins were significantly up-regulated in EIGC tissues, and 64 proteins were significantly down-regulated in EIGC tissues. IHC results showed that proteins IPO4, TBL1XR1, p62/SQSTM1, PKP3, and CRTAP were highly expressed in the cytoplasm of EIGC and LGIN, which was consistent with the quantitative results of DIA-MS. Among them, p62/SQSTM1 may undergo nuclear-cytoplasmic transfer. The expression of noncancerous gastric mucosa was different from LGIN and EIGC, while LGIN was similar to EIGC. The five protein coding genes were associated with intestinal-type gastric cancer survival and differentially expressed in different stages.
Conclusion: The study successfully identified differentially expressed proteins between EIGC and NGC, which may provide valuable insights into the mechanism of intestinal-type gastric cancer. Additionally, the study highlights the risk of some LGIN developing into invasive gastric cancer, which warrants further attention.
Brown vs Green Energy Sources and Resource Productivity: The Role of Human Capital and Technology Transfer in Developing Economies
Authors: Aladejare Samson Adeniyi , Salihu Bobbo 
Published: July 2023

AbstractThis study determined the impacts of non-renewable and renewable energy consumption on natural resource productivity alongside human capital and technology transfer roles for 40 selected developing economies. The study relied on a dataset sourced between 1991 and 2021. The study applied the novel method of moments quantile regression (MMQREG) procedure for the analyses while ensuring inferential robustness through the fully modified ordinary least squares (FMOLS), dynamic OLS (DOLS), and Driscoll-Kraay (D-K) methods. Empirically, the study revealed that an increase in brown energy consumption exhausted resource productivity from the lower to the upper quantiles. In contrast, green energy utilisation enhanced resource productivity from the lower to the higher quantiles. Also, while human capital adversely affected resource productivity for both energy means, technology transfer positively impacted it from the lower to the upper quantiles. Likewise, inferences from the DOLS, FMOLS, and D-K techniques revealed similar findings. However, despite non-renewable energy being the dominant means of energy in these developing economies, the size of its adverse impact on resource productivity falls short of the increasing effect of renewable energy across all quantiles. Also, the magnitude of the negative impact of human capital on resource productivity is marginally more substantial with non-renewable energy. In contrast, the robustness of the enhancing impact of technology transfer is slightly more with renewable energy.JEL Classification:O47, Q2, Q32.
Ionic Porous Organic Polymers Synthesized Using Solvothermal and Mechanochemical Methods as Solid Electrolytes for Lithium Metal Batteries
Authors: Luo Hang , Ho Gerald Siu Hang Poon , Li Chen , Huang Jun , Xu Zheng-Long , Kim Yoonseob 
Published: July 2023

Abstract
Lithium metal batteries (LMBs) have considerable potential to become the next generation of energy storage devices because of their high energy density. However, when used with liquid electrolytes, dendrite growth and thermal runaway can cause serious safety problems. Solid-state electrolytes with high Li+ conductivity, durability, and stability can effectively solve these problems. However, existing solid electrolytes do not meet the desirable criteria of having low interfacial contact, high electrochemical stability, high conductivity, and low manufacturing cost. Herein, we demonstrate that Li+-coordinated silicate and sulfonate porous organic polymers (denoted as Li+@Si-S-POPs) synthesized using solvothermal (ST) and mechanochemical (MC) methods can be used as solid electrolytes for LMBs. Benefiting from the incorporated ionic groups, permanent porosity, and low interfacial resistance, products synthesized using ST and MC methods exhibited high Li+ conductivity values of 1.1 × 10− 4 and 1.5 × 10− 4 S cm− 1 at room temperature and Li+ transference numbers of 0.94 and 0.96, respectively. Such excellent conduction behaviors facilitate high Li plating/stripping stability on Li metal electrodes, demonstrating the potential of Li+@Si-S-POPs for use in solid-state LMBs.
A systematic approach to numerical analysis and validation for industrial oven design and optimization
Authors: Şahin Serdar 
Published: July 2023

Abstract

This article presents a study on optimizing the internal velocity and heat distribution in an industrial belt oven with forced convection. The oven is primarily used for drying and cooking legumes. Computational fluid dynamics (CFD) and the Taguchi design of experiment methods were employed to determine the influential design variables. The 3D CFD model was then compared with experimental results to validate its accuracy. The oven comprises a permeable stainless-steel belt and axial fans with stick-type heaters, which facilitate the circulation of hot air. By assessing the fans' locations and the back chamber geometry, the internal flow patterns were analyzed to enhance airflow distribution. Design variables including the number of fans, the distance between fans, and the distance from fans to the belt surface were considered. Evaluation criteria encompassed belt surface temperature deviation and belt surface velocity deviation. An experimental oven design was developed based on optimal signal-to-noise (S/N) ratios, and the numerical findings were corroborated through experimental measurements, demonstrating a strong agreement. The proposed approach, encompassing the design, manufacturing, and analysis stages, can be applied to diverse industrial oven designs.
Optimization of hydraulic simulation, computational time, and mesh size of 2D and 3D models applied to the main open channel of the Pocsi district, city of Arequipa
Authors: Yana Ernesto , Aleman Sarahid , Yana Walter 
Published: July 2023

Abstract
Currently, in Peru engineering is going through a period of computer revolution, which means that knowledge related to new technologies must be constantly updated, having as tools data processing programs and software to obtain accurate results and optimize the development time of hydraulic projects. The present research determined the optimization of the computational time and mesh size of an open channel using the 2D models of Iber and 3D of Flow 3D. Therefore, the methodology of the study identified a quantitative approach, type of analytical research and experimental design. Moreover, for the development of the research, the following variables were identified: mesh size, computational time, 2D and 3D modelling. At first, the channel was sectioned into 12 sections of different roughness and then simulated with two computers of different characteristics and finally performed a comparative analysis of the models. By correlating the measurement of computational time with the level of accuracy and precision of the mesh size, an optimal model could be obtained. Finally, the hydraulic response in 2D and 3D models maintains an acceptable margin. In brief, 2D models have a shorter computational time and high performance in hydraulic structures and 3D models boast greater computational time and high impact of detail sensitivity in suggestive phenomena.
Investigation of optical, Thermal studies on semi organic Nonlinear Optical Single Crystal Thiosemicarbazide Potassium Bromide (TSCPB) for Optoelectronic devices applications
Authors: Rajeshwari S. , Raja R. , Saravanan N. , Chithambaram V 
Published: July 2023

Abstract
The Thiosemicarbazide Potassium Bromide (TSCPB) single crystals have been grown by the slow evaporation solution growth technique. The lattice parameters and crystalline nature of the grown TSCPB crystals have been studied by single XRD analysis. The chemical composition and the corresponding functional groups of the grown TSCPB have been confirmed by FTIR studies. The optical transparency of TSCPB in the visible region has been confirmed by the UV-Vis-NIR spectrum, and it has also been ensured by the maximum wavelength emission from the photoluminescence study. The band gap of the TSCPB material was calculated from optical absorption studies. The DSC analysis ascertained the thermal stability of the material. The morphology of the grown TSCPB crystal was studied. The second harmonic generation of TSCPB crystal has been determined by the standard Kurtz and Perry powder method.
ALZET pump implantation in mice for chronic drug delivery
Authors: Depreux Frederic , Whitlon Donna , Richter Claus-Peter 
Published: July 2023

Abstract
Drugs, chemical compounds, and other elements are often delivered to the ear of experimental animals to manipulate cochlear function, study how the ear works, identify drugs that prevent hearing loss, and test for ototoxicity. Delivery procedures for acute studies have been described in the literature. However, detailed information on methods that allow weeks of continuous drug delivery to mice cochleae is sparse. This paper describes a method for chronic drug delivery to the mouse cochlea. We illustrate the steps for the surgical implantation of an ALZET infusion pump and the placement of its catheter. We propose a ventral approach to the cochlea, using a surgical laser to make the cochleostomy and the placement of the pumps’ delivery ports into scala tympani or scala vestibuli. Depending on the experimental questions to be tested, the catheter can be directed toward the cochlear base, the vestibular system, or the cochlear apex.
Forgotten Women Artisans? New frontiers of Gendered Spaces in Gede City State in Coastal Kenya
Authors: Muthegethi David Maina 
Published: July 2023

AbstractThis paper interrogates how economic exchanges created new frontiers for women artisans in Gede city, at the coastal region of Kenya as demonstrated in archaeological records. Gede City state experienced economic development from the 11thcentury through intensification of international trade, rapid urbanization and diversification of subsistence patterns. This led to the emergency of artisan classes. Men artisans were mostly engaged in metal working and boat building whereas women artisans engaged in ceramics manufacturing and beads making. Before 11thcentury, the Gede community engaged in these activities mainly for subsistence use. The intensification of international trade and rapid urbanization from the 11thCentury however led to the commodification of ceramics, metal objects, cloth and beads between the Gede community and the people from the hinterland. The Gede community exchanged goods such as beads, metal objects, cloths and ceramics for ivory, animal skins and precious stones. They then traded these goods from the hinterland with foreign merchants thereby making Gede a mercantile City. These new opportunities were contested by different social identities and became new frontiers where gender identities were expressed.This paper aim is twofold: it examines how Gede gendered activities were contested through re-organization of the society’s social structures and how women activities were reflected in new structures from archaeological record.Data was collected through historical sources, archival materials and excavation on Gede Industrial Complex of Bead Making as Women Space. The central question that the paper addresses is: How did the reorganization of the Gede economy create new gendered spaces for women artisans in Gede state?
Changes in structural units in dough and bread from wheat flour with the addition of pumpkin cellulose in combination with phospholipids
Authors: Shevchenko Anastasiia , Litvynchuk Svitlana , Drobot Vira 
Published: July 2023

Unfavorable ecological and food security situation in the world causes frequent spread of diseases of the gastrointestinal tract. In particular, the number of cases of irritable bowel syndrome is increasing, especially among the young working population. Diet therapy, which includes increasing the amount of dietary fiber in combination with phospholipids, is effective for the prevention of these diseases. A perspective raw material with a high content of dietary fibers is pumpkin cellulose, which can be added to the recipe of bakery products instead of part of wheat flour. The aim of the work was to find the effect of pumpkin cellulose in combination with sunflower lecithin on the conformational changes of the structure of dough and bread from wheat flour and the completeness of assimilation of products with this raw material by the organism. It was established that the infrared spectra of wheat flour, pumpkin cellulose and sunflower lecithin differ in reflection intensity and character. In the process of dough fermentation, the conformational transformations deepened with an increase in the amount of replacement of wheat flour with pumpkin cellulose, and the reflection coefficient increased. For bread samples, the reflectance coefficient was lower compared to dough, but there were almost no differences in the location of the spectra. In general, the biological value of samples of bread with additives was lower than the control sample, however, the high content of dietary fibers in pumpkin cellulose makes it a promising raw material for enriching bakery products with a valuable nutrient and giving bread health properties. The rational amount of replacing wheat flour with pumpkin cellulose is no more than 7 %, taking into account the decrease in the biological value of bread with this raw material