bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coproducing Wellbeing Policy: A Theory of Thriving in Financial Hardship
Authors: Fabian Mark , Alexandrova Anna , Nair Yamini Cinamon 
Published: September 2023

AbstractWe describe a replicable process for coproducing a theory of ‘thriving’, or more broadly ‘wellbeing’, in partnership with stakeholders to inform an area of policy. Coproduction promotes effectiveness, practicality, and legitimacy of wellbeing policies by combining insights from people with lived experience of that policy, the practitioners who implement it, and technical experts with relevant area specific knowledge. We illustrate our methodology using a case study of a coproduction exercise between wellbeing researchers and practitioners and users of Turn2us, a UK-based anti-poverty charity. We report both the process developed for this collaboration and the bespoke theory and measures of thriving in financial hardship that emerged from it. We emphasise the interplay between different types of inputs: quantitative and qualitative data, academic theories of wellbeing and lived experience, and formal and informal insights. Our experience demonstrates the value of contextualising wellbeing for practical contexts, serving as an important complement to top-down approaches relying on standardised theories and metrics.
Investigation the efficacy of antipsoriatic drugs by blood plasma thermoanalysis
Authors: Ferencz Andrea , Moezzi Mehdi , Lőrinczy Dénes 
Published: September 2023

AbstractPsoriasis is an immune cell-mediated mainly inflammatory skin disease where patients may become asymptomatic after systemic drug therapies or nevertheless mild-to-moderate symptoms or exacerbating of either severe symptom should be detected. In addition to know the general change of blood plasma, the aim of the recent study was to detect the effect of antipsoriatic drug treatment to the patients’ symptoms by differential scanning calorimetry (DSC). The study included patients of both sexes who had different symptoms despite treatment with antipsoriatic medication (cytostatic agents, retinoids, biological treatment, n = 10 in each group). After the examination by dermatologist, the definition of symptoms severity was established on PASI (Psoriasis Area Severity Index) score. Blood plasma calorimetric changes were measured with calorimeter device. In the examined psoriatic patients, the thermodynamic parameters: denaturation temperature and calorimetric enthalpy of the transitions in proportion, corresponded to the degree of disease severity after targeted treatments with cytostatic or retinoid agents or following biological response modifier therapy. In conclusion, plasma DSC profiles were associated with response to antipsoriatic agents, which was associated with the presence or absence of symptoms after treatment.
Hyperelastic constitutive model parameters identification using optical-based techniques and hybrid optimisation
Authors: Mollaee Saeed , Budgett David M. , Taberner Andrew J. , Nielsen Poul M. F. 
Published: September 2023

AbstractIn this paper we propose a new optical-based technique to identify the constitutive relation coefficients of the hyperelastic material using a hybrid optimisation approach. This technique can be used in place of traditional mechanical testing of elastomers for applications that involve inhomogeneous deformation. The purpose of the proposed method is to identify the incompressible hyperelastic material constitutive relation coefficients using a single experiment under different loading cases. The method comprises sample surface 3D reconstruction and uses finite element simulations to replicate the experiments, and uses a hybrid optimisation technique to minimise the error between actual 3D deformations and FE simulation results. The proposed hybrid technique predicts the hyperelastic constitutive relation coefficients more accurately than other optimisation methods. This study introduces a novel approach by employing a subpixel image registration algorithm for 3D reconstruction. The method requires a single experiment with diverse loading cases to accurately determine the coefficients of hyperelastic constitutive relations. The setup is portable and can be accommodated in a small suitcase. For this purpose, an apparatus was constructed comprising a stereoscopic system with eight cameras and a six-degree-of-freedom force-torque sensor to measure the induced forces and torques during the experiments. We identified the constitutive relation coefficients of Ogden N1, Ogden N3, Yeoh, and Arruda-Boyce relations which are commonly used models for silicone materials, using a traditional uniaxial test, optical uniaxial test (experiments performed using a constructed optical system), and inhomogeneous deformations tests. The study demonstrated that the coefficients obtained from inhomogeneous deformation tests provided the most accurate FE predictions. It was also shown that hyperelastic constitutive relation coefficients obtained from traditional uniaxial tests are insufficient to describe the material behaviour when the material undergoes inhomogeneous deformations.
MDMA targets miR-124/MEKK3 via MALAT1 to promote Parkinson’s disease progression
Authors: Geng Xin , Li Shipeng , Li Jinghui , Qi Renli , Zhong Lianmei , Yu Hualin 
Published: September 2023

Abstract
Background
Parkinson’s disease (PD) is a well-known neurodegenerative disease that is usually caused by the progressive loss of dopamine neurons and the formation of Lewy vesicles. 3,4-Methylenedioxymethamphetamine (MDMA) has been reported to cause damage to human substantia nigra neurons and an increased risk of PD, but the exact molecular mechanisms need further investigation.

Methods
MPTP- and MPP+-induced PD cells and animal models were treated with Nissl staining to assess neuronal damage in the substantia nigra (SN) area; immunohistochemistry to detect TH expression in the SN; TUNEL staining to detect apoptosis in the SN area; Western blotting to detect the inflammatory factors NF-κB, TNF-α, IL-6 and mitogen-activated protein kinase kinase kinase 3 (MEKK3); Griess assay for NO; RT‒qPCR for metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and miR-124 expression; Cell proliferation was assessed by CCK-8. Dual luciferase reporter genes were used to verify targeting relationships.

Results
MDMA promoted MALAT1 expression, and knockdown of MALAT1 alleviated the MDMA-induced inhibition of SH-SY5Y cell proliferation, inflammation, NO release, SN neuronal injury, and TH expression inhibition. Both inhibition of miR-124 and overexpression of MEKK3 reversed the neuroprotective effects exhibited by knockdown of MALAT1.

Conclusion
MDMA promotes MALAT1 expression and inhibits the targeted downregulation of MEKK3 by miR-124, resulting in upregulation of the expression of MEKK3 and finally jointly promoting PD progression.
Importance of satisfying thermodynamic consistency in optoelectronic device simulations for high carrier densities
Authors: Farrell Patricio , Moatti Julien , O’Donovan Michael , Schulz Stefan , Koprucki Thomas 
Published: September 2023

AbstractWe show the importance of using a thermodynamically consistent flux discretization when describing drift–diffusion processes within light emitting diode simulations. Using the classical Scharfetter–Gummel scheme with Fermi–Dirac statistics is an example of such an inconsistent scheme. In this case, for an (In,Ga)N multi quantum well device, the Fermi levels show an unphysical hump within the quantum well regions. This result originates from neglecting diffusion enhancement associated with Fermi–Dirac statistics in the numerical flux approximation. For a thermodynamically consistent scheme, such as the SEDAN scheme, the humps in the Fermi levels disappear. We show that thermodynamic inconsistency has far reaching implications on the current–voltage curves and recombination rates.
Physiological phenotypes have optimal values relevant to healthy aging: sweet spots deduced from the Canadian Longitudinal Study on Aging
Authors: Vishnyakova Olga , Song Xiaowei , Rockwood Kenneth , Elliott Lloyd T. , Brooks-Wilson Angela 
Published: September 2023

AbstractPrevious observations on a group of exceptionally healthy “Super-Seniors” showed a lower variance of multiple physiological measures relevant for health than did a less healthy group of the same age. The finding was interpreted as the healthier individuals having physiological measurement values closer to an optimal level, or “sweet spot.” Here, we tested the generalizability of the sweet-spot hypothesis in a larger community sample, comparing differences in the variance between healthier and less healthy groups. We apply this method to the Canadian Longitudinal Study on Aging (CLSA) comprehensive cohort of 30,097 participants aged 45 to 85 years with deep phenotype data. Data from both sexes and four age ranges were analyzed. Five instruments were used to represent different aspects of health, physical, and cognitive functioning. We tested 231 phenotypic measures for lower variance in the most healthy vs. least healthy quartile of each sex and age group, as classified by the five instruments. Segmented regression was used to determine sex-specific optimal values. One hundred forty-two physiological measures (61%) showed lower variance in the healthiest than in the least healthy group, in at least one sex and age group. The difference in variance was most significant for hemoglobin A1c and was also significant for many body composition measurements, but not for bone mineral density. Ninety-four phenotypes showed a nonmonotonic relationship with health, consistent with the idea of a sweet spot; for these, we determined optimal values and 95% confidence intervals that were generally narrower than the ranges of current clinical reference intervals. These findings for sweet spot discovery validate the proposed approach for identifying traits important for healthy aging.
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
Authors: Pandics Tamas , Major David , Fazekas-Pongor Vince , Szarvas Zsofia , Peterfi Anna , Mukli Peter , Gulej Rafal , Ungvari Anna , Fekete Monika , Tompa Anna , Tarantini Stefano , Yabluchanskiy Andriy , Conley Shannon , Csiszar Anna , Tabak Adam G. , Benyo Zoltan , Adany Roza , Ungvari Zoltan 
Published: September 2023

AbstractThe aging population worldwide is facing a significant increase in age-related non-communicable diseases, including cardiovascular and brain pathologies. This comprehensive review paper delves into the impact of the exposome, which encompasses the totality of environmental exposures, on unhealthy aging. It explores how environmental factors contribute to the acceleration of aging processes, increase biological age, and facilitate the development and progression of a wide range of age-associated diseases. The impact of environmental factors on cognitive health and the development of chronic age-related diseases affecting the cardiovascular system and central nervous system is discussed, with a specific focus on Alzheimer’s disease, Parkinson’s disease, stroke, small vessel disease, and vascular cognitive impairment (VCI). Aging is a major risk factor for these diseases. Their pathogenesis involves cellular and molecular mechanisms of aging such as increased oxidative stress, impaired mitochondrial function, DNA damage, and inflammation and is influenced by environmental factors. Environmental toxicants, including ambient particulate matter, pesticides, heavy metals, and organic solvents, have been identified as significant contributors to cardiovascular and brain aging disorders. These toxicants can inflict both macro- and microvascular damage and many of them can also cross the blood–brain barrier, inducing neurotoxic effects, neuroinflammation, and neuronal dysfunction. In conclusion, environmental factors play a critical role in modulating cardiovascular and brain aging. A deeper understanding of how environmental toxicants exacerbate aging processes and contribute to the pathogenesis of neurodegenerative diseases, VCI, and dementia is crucial for the development of preventive strategies and interventions to promote cardiovascular, cerebrovascular, and brain health. By mitigating exposure to harmful environmental factors and promoting healthy aging, we can strive to reduce the burden of age-related cardiovascular and brain pathologies in the aging population.
Identification of Novel Circular RNA Targets in Key Penumbra Region of Rats After Cerebral Ischemia-Reperfusion Injury
Authors: Ye Jiabei , Shan Yudong , Zhou Xiaohong , Tian Tian , Gao Weijuan 
Published: September 2023

AbstractCircular RNAs (circRNAs) are abundantly and stably expressed in the brain of mammals and humans. Some circRNAs are implicated in ischemic stroke. Therefore, we aimed to detect how circRNAs change in the key penumbra area during cerebral ischemia-reperfusion (CI/R) injury. Rats were subjected to transient middle cerebral artery occlusion (tMCAO), during which the permanent blocking period was 2 h and reperfusion time was 24 or 72 h. Then modified neurologic severity score (mNSS), triphenyl tetrazolium chloride (TTC) staining and HE staining were used to exhibiting damage between rats in different groups. The penumbra regions of all rats were dissected and total RNA was further processed for high-throughput sequencing. CircRNA expression profiles were screened and bioinformatics analyses were conducted to investigate these differentially expressed circRNAs. Some of them were verified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), followed by the establishment of a circRNA-miRNA-mRNA network and the detection of their downstream molecules. A total of 99 and 98 circRNAs were differentially expressed at CI/R 24 h and CI/R 72 h, respectively. Notably, 21 circRNAs significantly changed at both reperfusion points. Three circRNAs, namely circ.7225, circ.5415, and circ.20623 were found to be associated with CI/R injury and might be preferred targets. Common downstream miR-298-5p and Bcl-3 were found to make up the circRNA-miRNA-mRNA network. Novel circRNA targets came to light in the penumbra of rats during CI/R injury and might establish the circRNA-miRNA-mRNA relationship, thus serving as potential biomarkers for ischemic stroke treatment.
PepperOSC: enabling interactive sonification of a robot’s expressive movement
Authors: Latupeirissa Adrian B. , Bresin Roberto 
Published: September 2023

AbstractThis paper presents the design and development of PepperOSC, an interface that connects Pepper and NAO robots with sound production tools to enable the development of interactive sonification in human-robot interaction (HRI). The interface uses Open Sound Control (OSC) messages to stream kinematic data from robots to various sound design and music production tools. The goals of PepperOSC are twofold: (i) to provide a tool for HRI researchers in developing multimodal user interfaces through sonification, and (ii) to lower the barrier for sound designers to contribute to HRI. To demonstrate the potential use of PepperOSC, this paper also presents two applications we have conducted: (i) a course project by two master’s students who created a robot sound model in Pure Data, and (ii) a museum installation of Pepper robot, employing sound models developed by a sound designer and a composer/researcher in music technology using MaxMSP and SuperCollider respectively. Furthermore, we discuss the potential use cases of PepperOSC in social robotics and artistic contexts. These applications demonstrate the versatility of PepperOSC and its ability to explore diverse aesthetic strategies for robot movement sonification, offering a promising approach to enhance the effectiveness and appeal of human-robot interactions.
Characterization of Formed TRIP1180 Steel Sheet Surface After Stamping with PVD-Coated Tools
Authors: Bang Junho , Bae Gihyun , Kim Minki , Song Junghan , Lee Myoung-Gyu , Kim Hong-Gee 
Published: September 2023

Abstract
The wear tests are conducted on bending punches deposited with PVD CrN and AlTiCrN coatings using the newly proposed progressive die. Then, the surface quality of the formed product is characterized through the surface roughness measurement after forming of TRIP1180 steel sheets. The correlation between the tool wear, in terms of wear depth and roughness and the product surface roughness can be quantitatively analyzed. The results show that the roughness remains comparable to that of the as-received surface before failure occurs, which represents smooth product surface without severe scratches and defects. While micro scratches on the punch surface have no effect on the quality of the product surface, severe fretting wear on the punch surface leads to a deterioration in the surface quality. Once initiated in the stamping process, the wear progresses exponentially within short time. The wear is also characterized as less than the coating thickness, but it results in complete removal of the coating layer. The partially worn punch plows the product surface, causing surface scratches with grooves and ridges, resulting in the roughness of 1.0 μm. In contrast, the surface with completely damaged coatings is extremely rough, with the roughness of 2.0 μm. This study presents the efficient method to evaluate the tool wear progression by indirectly measuring the product surface quality with reliably high precision.

Graphical abstract
Investigating the nativity differences in the development of disability in Australia: findings from a nationally representative longitudinal survey
Authors: Jatrana Santosh , Pasupuleti Samba Siva Rao 
Published: September 2023

AbstractUsing data from multiple waves of the Household Income and Labour Dynamics in Australia survey, and Cox regression model with time-varying covariates, this study investigates how Foreign-Born men and women from english speaking (ES) and non-english speaking (NES) countries differ in their trajectories in developing long-term disability relative to Native-Born Australians. The results indicate that the risk of developing long-term disability increased with duration of residence among men from both ES countries and NES countries and women from NES countries, starting with a health advantage when their duration of residence was less than or equal to 10 years. However, they all lost their initial health advantage after 10 years or more years of their stay in Australia. We also found a mediating role of socioeconomic factors and English language proficiency in developing long-term disability for immigrant men and women from ES countries and immigrant women from NES countries respectively.
Comparison of Aging Simulation to Real Aging of Silicone Self-adhesives Tapes
Authors: Antosik Adrian Krzysztof , Mozelweska Karolina , Gziut Konrad 
Published: September 2023

AbstractThe paper presents a comparison of the aging of silicone self-adhesive tapes in real conditions and accelerated aging in laboratory conditions. In order to check the correlation between the tested tapes, the tapes were tested immediately 24 h after making and after aging to determine changes in values functional properties such as adhesion, cohesion and tack. The tapes were manufactured on the basis of a selected pressure-sensitive silicone adhesive, which were cross-linked after adding the cross-linker and different dye content. As a result of the compared simulation in the test chamber (accelerated aging) and 7 years aging test, values of useful properties (e.g. adhesion) were obtained similarly. In the presented work, the influence of the amount of dye on the properties of pressure-sensitive adhesives was also examined, which allowed to obtain samples with similar functional properties, easy to compare with each other. The samples together with the dye and the cross-linking compound were subjected to artificial conditions in the chamber (artificial aging) and stored for 7 years.
Strategies to Overcome Collaborative Innovation Barriers: The Role of Training to Foster Skills to Navigate Quadruple Helix Innovations
Authors: Barbosa-Gómez Luisa , Wailzer Magdalena , Soyer Laura , Gerhardus Anna , Estay Francisco González , Blok Vincent , Revuelta Gema 
Published: September 2023

AbstractQuadruple Helix Collaborations (QHCs) is a cooperation model in which industry, government, academia, and the public interact to innovate. This paper analyses the impact of a training intervention to provide specific knowledge, skills, and attitudes to deal with barriers commonly found in the progress of QHCs. We designed, implemented, and evaluated three training programs in Austrian, Colombian, Danish, and Spanish institutions. We analysed trainees’ (n = 66) and trainers’ (n = 9) perceptions to identify the competencies acquired with the intervention and the approach’s limitations. We used online questionnaires (35 trainees; 9 trainers), semi-structured interviews (10 trainees), and a focus group (6 trainers). Trainees answered positively regarding their self-perception about the impact of the course and highlighted the acquisition of inspiration for their practice (score 4.1 out of 5.0) and knowledge (3.7). In contrast, they perceived that a deeper interaction with other participants (2.7) was challenging. After the courses, 74% of respondents indicated that they know more about how QHCs work in practice, and 86% about collaboration or engagement methods. Moreover, participants plan to be more sensitive towards setting common goals (71%) and power imbalances (63%). Trainers’ perceptions align with those expressed by participants, except that they considered that the interaction amongst participants during the course was higher. Qualitative analysis of interviews with participants and the focus group with trainers provides more detail about the strengths and weaknesses of the intervention. Our study shows that the collaborative design and implementation of training impact the participant’s learning competencies, with potential implications in their medium- to long-term practice.