bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melanocytic Lesions With Peripheral Globules: Proposal Of An Integrated Management Algorithm
Authors: Cappilli Simone , Ribero Simone , Cornacchia Luigi , Catapano Silvia , Del Regno Laura , Quattrini Laura , D'Amore Alessandra , Federico Francesco , Broganelli Paolo , Peris Ketty , Di Stefani Alessandro 
Published: February 2023

Introduction: A peripheral rim of globules represents a marker of horizontal growth phase in nevi and is a common feature in children and adolescents. The observation of melanocytic lesion with peripheral globules (MLPG) in adulthood deserve more attention, since a melanoma may exhibits this feature albeit rarely. Risk stratified management recommendations considering a global clinical approach are still missing.
Objectives: To analyze current knowledge on MLPG and propose an integrated management algorithm stratified for age groups.
Methods: We conducted a narrative review of current published data on MPLG, analyzing clinical dermoscopic and confocal distinguishing features of melanoma from bening nevi.
Results: The risk of finding a melanoma when removing a MLPG increases with age especially in people >55 years old and results significantly higher on extremities, head/neck and in case of a single asymmetrical lesion, ≥6 mm in diameter. Dermoscopic features associated to melanoma diagnosis include atypical peripheral globules, asymmetrical distribution, multiple rims as well as globules reappearance after previous loss. In addition, wide blue-grey regression areas, atypical network, eccentric blotches, tan structureless peripheral areas and vascularizationare atypical dermoscopic features. Confocal worrisome findingss are represented by pagetoid cells within the epidermis, architectural disarrangement and atypical cells of the dermo-epidermal junction with irregular peripheral nests.
Conclusion: We proposed a multi-step age-stratified management algorithm integrating clinical, dermoscopic and confocal findings that may increase the early recognition of melanoma and avoid surgical excision of benign nevi.
Infections In Hospitalized Patients With Psoriasis In A Skin Referral Hospital
Authors: Zaredar Nafiseh , Mahmoudi Hamidreza , Soori Tahereh , Teimourpour Amir , Balighi Kamran , Salehi Farid Ali , Daneshpazhooh Maryam 
Published: February 2023

Introduction: Psoriasis and its treatments may predispose patients to various infections. This is considered one of the most significant complications in patients with psoriasis.
Objectives: In the present study, we aimed to determine the prevalence of infection in hospitalized psoriasis patients and its relationship with systemic and biologic treatments.
Methods: All hospitalized patients with psoriasis from 2018 to 2020 in Razi Hospital in Tehran, Iran, were studied and cases of infection were recorded.
Results: Overall, 516 patients were studied and 25 types of infection in 111 patients were found. The most common types of infection were pharyngitis and cellulitis, followed by oral candida, urinary tract infections, common cold, fever of unknown origin, and pneumonia. Female sex and pustular psoriasis were significantly associated with infection in psoriatic patients. Those patients who received prednisolone had a higher risk of infection, and those under treatment with methotrexate or infliximab had a lower risk of infection.
Conclusion: Overall, 21.5% of psoriasis patients in our study had at least one episode of infection. This demonstrates that the prevalence of infection in these patients is not low. Using systemic steroids was associated with a higher risk of infection, while using methotrexate or infliximab was concomitant with a lower risk of infection.
Limited Access to Dermatology Specialty Care: Barriers and Teledermatology
Authors: Duniphin Darlla 
Published: February 2023

Introduction: Access to dermatology specialty care is limited in the underserved population. Barrier identification and exploring the potential role of teledermatology are the first steps to address this problem.
Objectives: Identify the barriers to dermatologist care for diagnosis and treatment of melanoma and non-melanoma skin cancers in the underserved population. Additionally explored was the potential role of teledermatology to provide dermatology care access in the underserved population.
Methods: A quantitative descriptive study was conducted via an online survey instrument. The survey’s barriers portion was adapted from the 1998 Ohio Family Health Survey (OFHS). The survey’s teledermatology portion was adapted from the McFarland Teledermatology Provider and Imaging Technician Satisfaction Survey. The participants were practicing dermatologists and members of Georgia, Missouri, Oklahoma, and Wisconsin dermatology associations. Thirty-eight responded to demographic questions, of which twenty-two responded to the survey items.
Results: The top three barriers ranked as the most concerning were continually uninsured (n = 8; 36.40%), resides in a medically underserved county (n = 5; 22.70%), and family under federal poverty level (n = 7; 33.30%). Teledermatology as a potential role for access to care was supported by convenient delivery of healthcare (n = 6; 72.70%), an addition to regular patient care (n = 20; 90.90%), and increase to patient care access (n = 18; 81.80%).
Conclusion: Barrier identification and teledermatology access to provide care to the underserved population is supported. Further teledermatology research is necessary to address the logistics regarding how to initiate and deliver teledermatology to the underserved.
MAN AS A FUNCTION OF TIME IN THE "KOZYREV SPACE"
Authors: Трофимов Александр Васильевич , Иванчук Сергей Викторович , Шимчишина Оксана Викторовна 
Published: February 2023

Время - важнейшая ценность Мы всегда должны понимать смысл времени и использовать его соответственно в позитивном ключе, чтобы выполнить какую-то цель. Время очень дорого для всех нас. Мы должны ценить и уважать важность времени каждый момент. Время - главная ценность в жизни человека.
Time is the most important value We should always understand the meaning of time and use it accordingly in a positive way in order to achieve some goal. Time is very precious to all of us. We must value and respect the importance of time in every moment. Time is the main value in human life.
ПОСТРОЕНИЕ АРХИТЕКТУРЫ РИСКОВ В ХОЗЯЙСТВЕ АВТОМАТИКИ, ТЕЛЕМЕХАНИКИ И СВЯЗИ
Authors: Иванов Владимир Эдуардович , Тришин Никита Алексеевич 
Published: February 2023

Обеспечение безопасности движения поездов было и до сих пор остается ключевым моментом железнодорожного транспорта, однако парадокс заключается в том, что в процессе своей деятельности он является источником рисков. Риск представляет собой сочетание вероятности возникновения нежелательного события и его последствий, которые проявят себя в случае возникновения этого события.
Ensuring the safety of train traffic was and still remains the key point of railway transport, but the paradox is that in the course of its activities it is a source of risks. Risk is a combination of the probability of an undesirable event and its consequences, which will manifest themselves in the event of this event.
THE EUROPEAN MENTALITY OF MODERN TIMES AND THE PROBLEM OF SUICIDE
Authors: Сиверцев Евгений Юрьевич 
Published: February 2023

В статье показывается, что оптимистический настрой менталитета Нового времени таит в себе серьёзную суицидогенную опасность. Понимание человеком того обстоятельства, что он имеет возможность исследовать мир и подчинять его себе ведёт к увеличению чувства ответственности и - в некоторых случаях - понижению самооценки.
The article shows that the optimistic attitude of the mentality of the New Time is fraught with serious suicidal danger. A person's understanding of the fact that he has the opportunity to explore the world and subordinate it to himself leads to an increase in the sense of responsibility and - in some cases - a decrease in self-esteem
Demographic Characteristics of Children with Biliary Atresia in dr. Kariadi General Hospital, Semarang
Authors: Kusumawati Ninung RD , Ritonga Ratna S , Kevin Christian , Sulaiman Sherynne , Siahaan Silviani S , Pratiwi Juwita 
Published: February 2023

Background: Biliary atresia (BA) is a progressive fibrosing obstructive cholangiopathy involving both the intrahepatic and extrahepatic biliary system; resulting in obstruction of bile flow and neonatal jaundice. Early diagnosis of biliary atresia and Kasai procedure improves patients outcome. Data form several studies revealed that BA is the most common cause of neonatal cholestasis (25%) and the leading cause of end-stage liver disease in pediatric population. The aim of this study is to determine the outcome and characteristics of children with biliary atresia in dr. Kariadi General Hospital, Semarang.
Methods: In this study, a retrospective database analysis of 80 infants diagnosed with biliary atresia was conducted. Patient’s demographic data including age, sex, age at disease onset, were collected from year 2018 to 2022; including all comorbidities and complications. Data regarding procedure performed for each patient and their outcome were included in this study.
Results: Eighty children were included in this study. The mean age of children referred with biliary atresia was 1.89 month, while the mean age at diagnosis was 2.5 month. Most of the patients were girls. The incidence of cytomegalovirus infection comorbidity in patients with biliary atresia is quite high, which were reported at 82%. Children diagnosed with biliary atresia and cytomegalovirus infection resulted in worse prognosis than those without.
Conclusion: Our study support the theories that biliary atresia may be caused by the exposure of external environment during perinatal period such as viral infection. The prognosis of patients with cytomegalovirus comorbidity is worse than that without.
Characteristics of Pediatric Patients with Diarrhea in Indonesia: A Laboratory-based Report
Authors: Amanda Lia , Utami Karin Nadia , Pulungan Andria Amanda , Rudiatmoko Diar Riyanti , Alatas Fatima Safira 
Published: February 2023

Background: Diarrhea is still a common health problem in Indonesia, with high morbidity and mortality rate. The severity of diarrhea is associated with age, nutritional status, and cause of diarrhea. This study aims to describe the characteristics and laboratory findings, particularly stool analysis, in pediatric patients with diarrhea.
Methods: A retrospective study was conducted using data from patients aged 0 to 18 with diarrhea who underwent stool analysis in Cipto Mangunkusumo Hospital between 2012 and 2016.
Results: The average age of children with diarrhea was 45 months, with most patients (55,6%) being under two years old children. More than half of the patients were boys (58.8%). Two-thirds of the patients (67%) presented with watery stool diarrhea. The interpretation of stool analysis indicated that nearly half of the patients (48%) experienced diarrhea due to bacterial infection, followed by fat malabsorption (20.8%). Similar results were also seen in the stool analysis of children aged 0-24 months, with the prevalence of bacterial infection (35.2%) and fat malabsorption (30.2%) being the most commonly identified etiology of diarrhea.
Conclusion: In Indonesia, children under two and male gender were more frequently reported to experience diarrhea. The primary manifestation of pediatric diarrhea was watery stools, while the most common etiology was bacterial infections.
Characterization of Grazed Vegetation within Mountainous Areas in the Plateau Region of Togo (West Africa)
Authors: Yawo Nenonene Amen , Akonta Dewa Kassa Kodjo , Béssan Amegnaglo Kossi , Léonard Agbodan Kodjovi Mawuégnigan , Koba Koffi 
Published: February 2023

Objectives: Livestock production systems in Togo are still dependent on availability of natural vegetation for livestock feed. The present study aims at characterizing grazed vegetation of the Plateau Region. More specifically, the aim is to inventory forage species and analyze their diversity.
Methodology: In order to characterize the grazed plant communities of the zone, phytosociological surveys were carried out at six sites, namely: Nyidové and Djamakondji (Agou), Dalia (Haho), Tchella (Ogou), Onè (Amou) and Mempeassem (Danyi). A total of 140 plots (10mx10m), twenty per site, were installed and investigated using the Braun-Blanquet method. Ecological parameters (bush fires, grazing, biomass removal, etc.) are the main factors responsible for the loss of forage diversity and degradation of plant cover on the sites.
Abstract: A total of 87 species were inventoried, mainly in the families Asteraceae, Poaceae, Fabaceae, Euphorbiaceae and Rubiaceae. Among the species identified, the most palatable are Panicum maximum (Poaceae), Centrosema pubescens (Fabaceae) and Sporobolus pyramidalis (Poaceae).The palatability index of available vegetation varies from site to site. It is low (IS<4) on two of the sites without good grasses or legumes (Dalia and Tchella) and average (IS<5) on the other sites with good quality. As for biological families, the most represented are Asteraceae, Poaceae, Euphorbiaceae, Fabaceae, etc. Mesophanerophytes, champhytes, therophytes, microphanerophytes, nanophanerophytes and hemicryptophytes are the most predominant biological life forms while pantropicals are more represented in Dalia (40%) and Tchella (49%). Chromolaena odorata (92.85%), Imperata cylindrica (78.57%), Tridax procumbens (64.28%) non-consumed invasive species are very much represented and reflect the state of degradation of grazed vegetations.
Conclusion: The results of this study will be used for pastoral management work in the area.
Frequency and Characteristics of Trials Using Medical Writer Support in High-Impact Oncology Journals
Authors: Buck Eva , Haslam Alyson , Tuia Jordan , Prasad Vinay 
Published: February 2023

ImportanceThe practice of using medical writers to communicate scientific information has gained popularity, but it may affect how and what information is communicated.ObjectiveTo assess characteristics of oncology trials that use medical writers and whether there is an association between the use of medical writers and trial success or the primary outcome evaluated.Design, Setting, and ParticipantsThis cross-sectional study included oncology trials testing a tumor-targeting intervention that were published in The Lancet, The Lancet Oncology, JAMA, JAMA Oncology, Journal of Clinical Oncology, and The New England Journal of Medicine between May 1, 2021, and May 1, 2022.ExposuresAssistance of medical writers or no assistance.Main Outcomes and MeasuresThe main outcomes were the percentage of studies with medical writers, the percentage of trial successes reported with medical writers, the association between trial success and medical writer use, and the association between a primary end point and medical writer use.ResultsAmong 270 studies, 141 (52.2%) included a medical writer and 129 (47.8%) did not include a medical writer. Of the studies that included a medical writer, 83 (58.9%) were successful. Of the studies that did not include a medical writer, 64 (49.6%) were successful (P = .16 for difference). Studies with medical writers were less likely than studies without medical writers to have the end point of overall survival (15 [10.6%] vs 17 [13.2%]) and disease-free or event-free survival (16 [11.3%] vs 29 [22.5%]), whereas studies with a medical writer were more likely to have the end point of progression-free survival (32 [22.7%] vs 17 [13.2%]). Use of medical writer was associated with the conclusions being presented favorably in all studies (113 [80.1%] vs 89 [69.0%]; odds ratio [OR], 1.81 [95% CI, 1.04-3.19]), but when adjusted for other variables, there was no association (OR, 1.84 [95% CI, 0.92-3.72]).Conclusions and RelevanceIn this cross-sectional study, trials using medical writers were more likely to report surrogate end points, such as progression-free survival, and favorable conclusions, but when adjusted for trial phase, randomization, and study funding, there was no association with favorable conclusions. These findings suggest that journals need heightened scrutiny for studies with medical writers and that authorship should be properly acknowledged.
Recent Progress of Conductive Hydrogel Fibers for Flexible Electronics: Fabrications, Applications, and Perspectives
Authors: Li Wanwan , Liu Jiao , Wei Jingnan , Yang Zhaoyan , Ren Chunlei , Li Bingxiang 
Published: February 2023

AbstractFlexible conductive materials with intrinsic structural characteristics are currently in the spotlight of both fundamental science and advanced technological applications due to their functional preponderances such as the remarkable conductivity, excellent mechanical properties, and tunable physical and chemical properties, and so on. Typically, conductive hydrogel fibers (CHFs) are promising candidates owing to their unique characteristics including light weight, high length‐to‐diameter ratio, high deformability, and so on. Herein, a comprehensive overview of the cutting‐edge advances the CHFs involving the architectural features, function characteristics, fabrication strategies, applications, and perspectives in flexible electronics are provided. The fundamental design principles and fabrication strategies are systematically introduced including the discontinuous fabrication (the capillary polymerization and the draw spinning) and the continuous fabrication (the wet spinning, the microfluidic spinning, 3D printing, and the electrospinning). In addition, their potential applications are crucially emphasized such as flexible energy harvesting devices, flexible energy storage devices, flexible smart sensors, and flexible biomedical electronics. This review concludes with a perspective on the challenges and opportunities of such attractive CHFs, allowing for better understanding of the fundamentals and the development of advanced conductive hydrogel materials.
Engineering Tridimensional Hydrogel Tissue and Organ Phantoms with Tunable Springiness
Authors: Liu Desheng , Jiang Pan , Wang Yixian , Lu Yaozhong , Wu Jiayu , Xu Xin , Ji Zhongying , Sun Chufeng , Wang Xiaolong , Liu Weimin 
Published: February 2023

AbstractBiomimicking organ phantoms with vivid biological structures and soft and slippery features are essential for in vitro biomedical applications yet remain hither to unmet challenges in their fabrication such as balancing between spatial structural complexity and matchable mechanical properties. Herein, 3D printable tissue‐mimicking elastomeric double network hydrogels with tailorable stiffness are evolved to idiosyncratically match diverse biological soft tissues by regulating the compositions of hydrogel matrix and the density of metal coordination bonds. Relying on digital light processing 3D printing, various mechanically tunable biomimetic volumetric hydrogel organ constructs with structural complexity and fidelity, including kidney, brain, heart, liver, stomach, lung, trachea, intestine, and even the intricate vascularized tissues, are fabricated faultlessly. Proof‐of‐concept 3D printed hydrogel heart and liver phantoms provide sophisticated internal channels and cavity structures and external realistic anatomical architectures that more closely mimic native organs. For the in vitro application demonstration, a 3D printed hydrogel brain phantom with tortuous cerebral arteries and slippery characters serves as an effective neurosurgical training platform for realistic simulation of endovascular interventions. This platform offers a means to construct mechanically precisely tunable hydrogel‐based biomimetic organ phantoms that are expected to be used in surgical training, medical device testing, and organs‐on‐chips.
Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis
Authors: Song Jia , Zhang Xin , Yin Yue , Guo Mengfan , Zhao Xuyang , Wang Likun , Ren Caixia , Yin Yuxin , Zhang Xuehui , Deng Xuliang , Lu Dan 
Published: February 2023

AbstractThe peripheral T cell pool is maintained at dynamic homeostasis through fine‐tuning of thymic output and self‐renewal of naïve T cells. Lymphopenia or reduced lymphocyte number is implicated in autoimmune diseases, yet little is known about the homeostatic mechanisms. Here, it is reported that the replication protein A1 (RPA1) plays a critical role in T cell homeostasis. Utilizing T cell‐specific Rpa1‐deficient (Rpa1fl/fl Cd4‐cre) mice, loss of Rpa1 results in lymphopenia through restraining peripheral T cell population and limiting TCR repertoire diversity. Moreover, Rpa1fl/fl Cd4‐cre mice exhibit increased susceptibility to inflammatory diseases, including colitis and hepatitis. Clinical analysis reveals that the expression of RPA1 is reduced in patients with ulcerative colitis or other autoinflammatory diseases. Mechanistically, depletion of RPA1 activates ZBP1‐RIPK3 signaling through triggering the genomic DNA leakage into cytosol, consequently resulting in T cell necroptosis. This necroptotic T cell death induced by RPA1 deficiency allows the release of damage‐associated molecular patterns (DAMPs), which in turn recruits leukocytes and exacerbates inflammatory response. Reciprocally, chemical or genetic inhibition of necroptosis signaling can ameliorate the Rpa1 deficiency‐induced inflammatory damage. The studies thus uncover the importance of RPA1‐ZBP1‐RIPK3 axis in T cell homeostasis and provide a promising strategy for autoinflammatory disease treatment.
Tethered cord syndrome in KBG syndrome
Authors: Hills Sonia , Pugacheva Alisa , Weltin Patricia , Maughan Annette , Morton Sarah U. , Feldman Henry A. , Klinge Petra M. , Agrawal Pankaj B. 
Published: February 2023

AbstractTethered cord syndrome (TCS) is characterized by leg pain and weakness, bladder and bowel dysfunction, orthopedic malformations such as scoliosis, and motor deficits caused by the fixation of the spinal cord to surrounding tissues. TCS is surgically treatable and often found in conjunction with other syndromic conditions. KBG syndrome is caused by variants in the ANKRD11 gene and is characterized by short stature, developmental delay, macrodontia, and a triangular face. The current study explores the prevalence of TCS in pediatric KBG patients and their associated signs and symptoms. Patients with KBG were surveyed for signs and symptoms associated with TCS and asked if they had been diagnosed with the syndrome. We found a high proportion of patients diagnosed with (11%) or being investigated for TCS (24%), emphasizing the need to further characterize the comorbid syndromes. No signs or symptoms clearly emerged as indicative of TCS in KBG patients, but some the prevalence of some signs and symptoms varied by sex. Male KBG patients with diagnosed TCS were more likely to have coordination issues and global delay/brain fog than their female counterparts. Understanding the presentation of TCS in KBG patients is critical for timely diagnosis and treatment.