bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family Ties and Older Adult Well-Being: Incorporating Social Networks and Proximity
Authors: Patterson Sarah E , Margolis Rachel 
Published: September 2023

Abstract

Objectives
This paper examines the family ties of older adults in the United States and how they are associated with mental health and social activity. We compare older adults with 4 types of family ties: adults “close” to family in proximity and social network, “kinless” older adults without a partner or children, “distanced” adults who live far from close kin, and “disconnected” older adults who do not report kin in their social network or do not report a location for some kin.

Methods
Using pooled data from the National Health and Aging Trends Study 2015–2019 for older adults aged 70 and older (N = 24,818 person-waves), we examine how family ties are associated with mental health and social activity, and whether lacking family is tied to poor well-being because older adults’ needs are not being met.

Results
Kinless older adults and disconnected older adults have poorer outcomes (lower mental health scores and less social activity), compared to those close to their family. These findings suggest that both the presence and quality of the connection, as measured here via both location and social network, are critical for understanding which older adults are “at risk.” Older adults who were not geographically proximate to their close kin (i.e., distanced) were not disadvantaged relative to those close to their families. Unmet needs do not help explain these patterns.

Discussion
Our results highlight that family ties are important for older adults well-being, not just through their existence but also their quality and strength.
The Impact of Cat Fostering on Older Adult Well-Being and Loneliness: A Feasibility Study
Authors: Sanderson Sherry L , Emerson Kerstin G , Scott Donald W , Vidrine Maureen , Hartzell Diane L , Keys Deborah A 
Published: September 2023

Abstract

Objectives
This feasibility study explored the impact of fostering a shelter cat on loneliness and well-being in older adults living alone without a pet. The study also examined the effect of cat fostering on older adults’ interest in cat adoption when perceived barriers to adoption were removed.

Methods
A total of 29 adults (age ≥60) were paired with a cat and asked to foster for a minimum of 4 months (with an option to adopt). Participants completed surveys before placement with cats, with a follow-up at 1 and 4 months postplacement and 12 months if they adopted their cat. The survey included scales of loneliness, physical and mental health, self-efficacy, positive and negative affect, and comfort from a companion animal. Scores were compared across time using a Multivariable Linear Mixed Model.

Results
A total of 23 of 29 (79.3%) participants remained in the study for at least 4 months, and a majority (95.7%) adopted their cat. Differences in marginal means (adjusted for physical health) showed a significant improvement in loneliness from baseline to 4 months (p = .029). A similar 4-month improvement that approached statistical significance (adjusted p = .079) was observed for mental health. No other scales showed statistically significant changes across time.

Discussion
Fostering a shelter cat with the option for adoption may be an effective solution for alleviating loneliness and improving mental health in older adults. Interest in adopting foster cats was high when perceived barriers to adoption were removed.
Divergent phenotypes in constitutive versus conditional mutant mouse models of Sifrim-Hitz-Weiss syndrome
Authors: Larrigan Sarah , Joshi Shrilaxmi V , Mattar Pierre 
Published: September 2023

Abstract
Chromatin remodellers are among the most important risk genes associated with neurodevelopmental disorders (NDDs), however, their functions during brain development are not fully understood. Here, we focused on Sifrim-Hitz-Weiss Syndrome (SIHIWES)—an intellectual disability disorder caused by mutations in the CHD4 chromodomain helicase gene. We utilized mouse genetics to excise the Chd4 ATPase/helicase domain—either constitutively, or conditionally in the developing telencephalon. Conditional heterozygotes exhibited no change in cortical size and cellular composition, and had only subtle behavioral phenotypes. Telencephalon-specific conditional knockouts had marked reductions in cortical growth, reduced numbers of upper-layer neurons, and exhibited alterations in anxiety and repetitive behaviors. Despite the fact that whole-body heterozygotes exhibited comparable growth defects, they were unaffected in these behaviors, but instead exhibited female-specific alterations in learning and memory. These data reveal unexpected phenotypic divergence arising from differences in the spatiotemporal deployment of loss-of-function manipulations, underscoring the importance of context in chromatin remodeller function during neurodevelopment.
Abundant Neutrophil-Initiated Acute Myocardial Injury Following Coxsackievirus A6 Infection
Authors: Zhang Yu , Chen Shuaiyin , Sun Tiantian , Duan Guangcai , Yang Haiyan , Feng Huifen , Jiang Wenjie , Li Dong , Ji Wangquan , Zhu Peiyu , Jin Yuefei 
Published: September 2023

Abstract
Coxsackievirus A6 (CVA6) is currently considered as a predominant pathogen of hand, foot, and mouth disease (HFMD), and is occasionally linked to myocardial injury. We first established a mouse model of CVA6-induced myocardial injury. Next, we analyzed the immune cell phenotypes CVA6-infected mice hearts by fluorescence-activated cell sorting, and found that CVA6 led to massive neutrophils infiltration, suggesting their potential link with the occurrence of myocardial injury. We further used either αGr-1 or αLy6G antibody to deplete neutrophils, and found that neutrophil-depleted animals showed decreased cardiac enzymes, lower degree of pathology in hearts, and reduced inflammatory cytokine production compared to isotype controls. Finally, we confirmed the involvement of neutrophils in myocardial injury of clinical patients with severe HFMD. Our study suggests that excessive neutrophils contribute to myocardial injury caused by CVA6 infection, which provides new insights into myocardial injury during the development of HFMD severity and the outcome of immune cell-mediated therapies.
Susceptibility and diagnostic concentration for Bacillus thuringiensis toxins and newer chemical insecticides in Spodoptera frugiperda (Lepidoptera: Noctuidae) from China
Authors: Guan Fang , Zhang Zheng , Lin Yuhang , Liu Xiangjie , Wang Xingliang , Yang Yihua , Carrière Yves , Wu Yidong 
Published: September 2023

Abstract
The fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), is a cosmopolitan pest that exploits more than 350 host plants, including economically important crops such as corn, cotton and rice. Control of S. frugiperda largely relies on transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) and spraying synthetic insecticides. Here, we established the susceptibility and diagnostic concentration for 2 Bt toxins and 5 newer insecticides in invasive populations of S. frugiperda from southeastern China. Concentrations causing 50% mortality (LC50) in ten field populations sampled in 2022 ranged from 2.13 to 19.29 and 22.43 to 71.12 ng/cm2 for Cry1Fa and Vip3Aa, and 0.83 to 5.30, 2.83 to 9.94, 0.04 to 0.23, 4.59 to 8.40, and 1.49 to 6.79 mg/liter for chlorantraniliprole, chlorfenapyr, emamectin benzoate, indoxacarb, and spinosad, respectively. Relative to the susceptible strain YJ-19, the largest resistance ratio in the field populations was 5.1, 1.6, 6.2, 3.9, 4.6, 2.2, and 3.6 for Cry1Fa, Vip3Aa, chlorantraniliprole, chlorfenapyr, emamectin benzoate, indoxacarb, and spinosad, respectively, indicating that the field populations were generally susceptible to these Bt toxins and insecticides. Based on the pooled response of the field populations, the diagnostic concentration for resistance monitoring, estimated as ca. twice the LC99, was 400 and 1,500 ng/cm2 for Cry1Fa and Vip3Aa, and 2, 40, 60, 60, and 100 mg/liter for emamectin benzoate, chlorantraniliprole, chlorfenapyr, spinosad, and indoxacarb, respectively. These results provide useful information for monitoring resistance to key Bt toxins and insecticides for the control of S. frugiperda in China.
A reference genome for ecological restoration of the sunflower sea star, Pycnopodia helianthoides
Authors: Schiebelhut Lauren M , DeBiasse Melissa B , Gabriel Lars , Hoff Katharina J , Dawson Michael N 
Published: September 2023

Abstract
Wildlife diseases, such as the sea star wasting (SSW) epizootic that outbroke in the mid-2010s, appear to be associated with acute and/or chronic abiotic environmental change; dissociating the effects of different drivers can be difficult. The sunflower sea star, Pycnopodia helianthoides, was the species most severely impacted during the SSW outbreak, which overlapped with periods of anomalous atmospheric and oceanographic conditions, and there is not yet a consensus on the cause(s). Genomic data may reveal underlying molecular signatures that implicate a subset of factors and, thus, clarify past events while also setting the scene for effective restoration efforts. To advance this goal, we used Pacific Biosciences HiFi long sequencing reads and Dovetail Omni-C proximity reads to generate a highly contiguous genome assembly that was then annotated using RNA-seq-informed gene prediction. The genome assembly is 484 Mb long, with contig N50 of 1.9 Mb, scaffold N50 of 21.8 Mb, BUSCO completeness score of 96.1%, and 22 major scaffolds consistent with prior evidence that sea star genomes comprise 22 autosomes. These statistics generally fall between those of other recently assembled chromosome-scale assemblies for two species in the distantly related asteroid genus Pisaster. These novel genomic resources for P. helianthoides will underwrite population genomic, comparative genomic, and phylogenomic analyses—as well as their integration across scales—of SSW and environmental stressors.
Characterization of the swarming behavior of Anopheles coluzzii and Anopheles gambiae (Diptera: Culicidae) populations in a hybrid zone of Senegal
Authors: Gueye Oumou Kalsom , Niang Abdoulaye , Faye Mouhamed Bassir , Dia Abdoulaye Kane , Ahmed Amblat Ali , Sy Ousmane , Tripet Frederic , Konaté Lassana , Dia Ibrahima , Wondji Charles Sinclair , Gaye Oumar , Faye Ousmane , Diabate Abdoulaye , Niang El Hadji Amadou 
Published: September 2023

Abstract
Anopheles gambiae and Anopheles coluzzii, often found in sympatry and synchronous, have undergone a premating reproductive isolation across their distribution range. However, in the Western coast of Africa, unexpected hybridization zones have been observed, and little is known about swarming behavior of these cryptic taxa. Here, we characterized the swarming behavior of An. coluzzii and An. gambiae to investigate its role in the high hybridization level in Senegal. The study was conducted in the south and central Senegal during the 2018 rainy season. Mating swarms of malaria vectors were surveyed at sunset and collected using an insect net. Meanwhile, indoor resting populations of malaria vectors were collected by pyrethrum spray catches. Upon collection, specimens were identified morphologically, and then members of the An. gambiae complex were identified at the species level by polymerase chain reaction (PCR). An. gambiae swarmed mainly over bare ground, whereas An. coluzzii were found swarming above various objects creating a dark–light contrast with the bare ground. The swarms height varied from 0.5 to 2.5 m. Swarming starting time was correlated with sunset whatever the months for both species, and generally lasted about 10 min. No mixed swarm of An. gambiae and An. coluzzii was found even in the high hybridization area. These results indicated a premating isolation between An. coluzzii and An. gambiae. However, the high hybridization rate in the sympatric area suggests that heterogamous mating is occurring, thus stressing the need for further extensive studies.
Mapping current and future risk of scorpion sting from a species with low medical concern, Mesobuthus phillipsii (Scorpiones: Buthidae) in Iran
Authors: Kafash Anooshe , Hanafi-Bojd Ahmad Ali , Mohammadi Bavani Mulood , Shahi Mehran , Akbari Morteza , Rafinejad Javad , Bozorg Omid Faramarz , Hassanpour Gholamreza 
Published: September 2023

Abstract
Scorpion stings are one of the most important health challenges and high priority research topic in public health. In this study, we aimed to model habitat suitability of the Mesobuthus phillipsii (Pocock 1889), a species with low medical concern, under current and future climatic conditions in Iran. We also identified vulnerable populations to scorpion stings in the country. Scorpion sting risk modeling was done using an ensemble approach by considering two species distribution modeling methods: MaxEnt and Random Forest methods. Distribution modeling was performed using the sdm R package. The results showed that due to climate change in 2070, the high-risk areas will increase from 20,839 to 79,212 km2. Habitats with a moderate risk of scorpion stings will also increase from 139,347 to 222,833 km2. Consequently, the number of villages in high-risk areas of scorpion stings will increase from 2,870 to 7,017, while this number will increase from 12,759 to 20,104 in the case of medium-risk villages. The results of this study can be used for scorpion stings management in Iran. This study can be used as an example for similar studies on scorpions with high medical emergency.
A Scoping Review of the Complementary Feeding Practices and Early Eating Experiences of Children With Down Syndrome
Authors: Hielscher Laura , Irvine Karen , Ludlow Amanda K , Rogers Samantha , Mengoni Silvana E 
Published: September 2023

Abstract

Objective
Children with Down syndrome may experience more challenges in their early feeding and may be introduced to complementary foods comparatively later than typically developing (TD) children. This scoping review aimed to identify and synthesize the existing literature that describes feeding problems and early eating experiences relating to the period of complementary feeding for children with Down syndrome.

Methods
Scopus, PubMed, Medline, Web of Science, and PsycInfo were searched. Journal articles published between January 1991 and June 2022 that reported on the complementary feeding period with children with Down syndrome were included.

Results
Eighteen journal articles met the inclusion criteria. Children with Down syndrome were introduced to complementary foods later than TD children and progressed to more challenging food textures at a slower rate. Gross and fine motor skill delays and sensory difficulties contributed to secondary feeding problems such as difficulties chewing, biting, and reduced awareness of food on lips and tongue. Parents of children with Down syndrome reported exercising more caution and employing more controlling feeding practices compared to TD and had higher levels of concern regarding their child’s weight.

Conclusions
Guidelines and early feeding support specific to children with Down syndrome should be available before the first complementary foods are introduced and throughout this period. Feeding support should aim to address parental concerns and provide assistance when feeding problems occur, to minimize delays and encourage the optimum development of eating abilities. Future research should address the development of feeding problems during this period and explore possible interventions.
Sucrose phosphate synthase 8 is required for the remobilization of carbon reserves in rice stems during grain filling
Authors: Ma Mingyang , Zhu Tong , Cheng Xiuyue , Li Mengyu , Yuan Guoliang , Li Changbao , Zhang Aihong , Lu Congming , Fang Ying , Zhang Yi 
Published: September 2023

Abstract
Carbon reserve remobilization in stems is closely related to rice grain filling. Sucrose phosphate synthase (SPS) is highly associated with carbon reserve remobilization. In this study, we investigated the expression pattern of SPS genes in various rice tissues, and found that SPS8 is the major SPS isoform in rice stems during the grain-filling stage. We then constructed sps8 mutants using the CRISPR/Cas9 system. The SPS activity of the sps8 mutants was markedly reduced in the stems. In addition, the sps8 mutants exhibited significant starch accumulation in stems. 14C-labelling experiments revealed that the remobilization of non-structural carbohydrates from rice stems to grains was impaired in the sps8 mutants. In the sps8 mutants, grain filling was delayed and yield decreased by 15% due to a reduced percentage of ripened grains. RNA sequencing and quantitative PCR analyses indicated that the genes involved in starch synthesis and degradation were up-regulated in the sps8 mutant stems. In addition, the activity of the enzymes involved in starch synthesis and degradation was increased in the sps8 stems. These results demonstrate that SPS8 is required for carbon reserve remobilization from rice stems to grains, and that its absence may enhance ‘futile cycles’ of starch synthesis and degradation in rice stems.
The BarYon Cycle project (ByCycle): identifying and localizing Mg ii metal absorbers with machine learning
Authors: Szakacs Roland , Péroux Céline , Nelson Dylan , Zwaan Martin A , Grün Daniel , Weng Simon , Fresco Alejandra Y , Bollo Victoria , Casavecchia Benedetta 
Published: September 2023

ABSTRACT
The upcoming ByCycle project on the VISTA/4MOST multi-object spectrograph will offer new prospects of using a massive sample of ∼1 million high spectral resolution (R = 20 000) background quasars to map the circumgalactic metal content of foreground galaxies (observed at R = 4000–7000), as traced by metal absorption. Such large surveys require specialized analysis methodologies. In the absence of early data, we instead produce synthetic 4MOST high-resolution fibre quasar spectra. To do so, we use the TNG50 cosmological magnetohydrodynamical simulation, combining photo-ionization post-processing and ray tracing, to capture Mg ii (λ2796, λ2803) absorbers. We then use this sample to train a convolutional neural network (CNN) which searches for, and estimates the redshift of, Mg ii absorbers within these spectra. For a test sample of quasar spectra with uniformly distributed properties ($\lambda _{\rm {Mg\, {\small II},2796}}$, $\rm {EW}_{\rm {Mg\, {\small II},2796}}^{\rm {rest}} = 0.05\!-\!5.15$ Å, $\rm {SNR} = 3\!-\!50$), the algorithm has a robust classification accuracy of 98.6 per cent and a mean wavelength accuracy of 6.9 Å. For high signal-to-noise (SNR) spectra ($\rm {SNR \gt 20}$), the algorithm robustly detects and localizes Mg ii absorbers down to equivalent widths of $\rm {EW}_{\rm {Mg\, {\small II},2796}}^{\rm {rest}} = 0.05$ Å. For the lowest SNR spectra ($\rm {SNR=3}$), the CNN reliably recovers and localizes EW$_{\rm {Mg\, {\small II},2796}}^{\rm {rest}}$ ≥0.75 Å absorbers. This is more than sufficient for subsequent Voigt profile fitting to characterize the detected Mg ii absorbers. We make the code publicly available through GitHub. Our work provides a proof-of-concept for future analyses of quasar spectra data sets numbering in the millions, soon to be delivered by the next generation of surveys.
An investigation of the ‘10 keV feature’ in the spectra of accretion powered X-ray pulsars with NuSTAR
Authors: Manikantan Hemanth , Paul Biswajit , Rana Vikram 
Published: September 2023

ABSTRACT
Some of the accreting X-ray pulsars are reported to exhibit a peculiar spectral feature at ∼10 keV, known as the ‘10 keV feature’. The feature has been characterized as either an emission line or an absorption line, and its origin is unknown. It has been found in multiple observations of the same source by different observatories, but not all the observations of any particular source consistently showed the presence of it. In this work, we have carried out a systematic investigation for the presence of the ‘10 keV feature’ using data from NuSTAR, a low background spectroscopic observatory having uninterrupted wide band coverage on either side of 10 keV. We performed a systematic spectral analysis on 58 archival NuSTAR observations of 30 bright X-ray pulsars. The 3–79 keV spectral continua of these selected sources were fitted with a model chosen on the basis of its fitting quality in 3–15 keV and model simplicity, and then inspected for the presence of the ‘10 keV feature’. Our analysis indicates the presence of such a feature in 16 out of 58 the NuSTAR observations of 11 different sources and is fitted with a Gaussian absorption model centred around 10 keV. Our analysis also suggests that such a feature could be wrongly detected if flare data is not analysed separately from persistent emission.
A differentiable model of the evolution of dark matter halo concentration
Authors: Stevanovich Dash , Hearin Andrew P , Nagai Daisuke 
Published: September 2023

ABSTRACT
We introduce a new model of the evolution of the concentration of dark matter haloes, c(t). For individual haloes, our model approximates c(t) as a power law with a time-dependent index, such that at early times, concentration has a nearly constant value of c ≈ 3–4, and as cosmic time progresses, c(t) smoothly increases. Using large samples of halo merger trees taken from the Bolshoi–Planck and MultiDark Planck 2 cosmological simulations, we demonstrate that our three-parameter model can approximate the evolution of the concentration of individual haloes with a typical accuracy of 0.1 dex for $t\gtrsim 2\, {\rm Gyr}$ for all Bolshoi–Planck and MultiDark Planck 2 haloes of present-day peak mass $M_{0}\gtrsim 10^{11.5}\, {\rm M}_{\odot }$. We additionally present a new model of the evolution of the concentration of halo populations, which we show faithfully reproduces both average concentration growth and the diversity of smooth trajectories of c(t), including capturing correlations with halo mass and halo assembly history. Our publicly available source code, diffprof, can be used to generate Monte Carlo realizations of the concentration histories of cosmologically representative halo populations. diffprof is differentiable due to its implementation in the jax autodiff library, which facilitates the incorporation of our model into existing analytical halo model frameworks.
Search for a possible quasi-periodic structure based on data of the SDSS DR12 LOWZ
Authors: Ryabinkov A I , Kaminker A D 
Published: September 2023

ABSTRACT
We carry out a statistical analysis of the spatial distribution of galaxies at cosmological redshifts 0.16 ≤ z ≤ 0.47 based on the SDSS DR12 LOWZ catalogue. Our aim is to search and study possible large-scale quasi-regular structures embedded in the cosmic web. We calculate projections of the Cartesian galaxy coordinates on different axes (directions), densely covering certain regions in the sky to look for special directions along which 1D distributions of the projections contain significant quasi-periodic components. These components appear as peaks in the power spectra and lie in a narrow range of wave numbers 0.05 &lt; k &lt; 0.07. Particular attention is paid to the evaluation of the significance of the peaks. It is found that the significance of the dominant peaks for some selected directions exceeds (4–5)σ. In order to reduce possible selection effects, we create a mock homogeneous catalogue of spatial distribution of galaxies by adding a random set of artificial objects (points) to the real galaxies under study. The power spectrum of this cumulative model data also demonstrates significant peak corresponding to approximately the same scale. As a result we assume the existence of an anisotropic cosmological quasi-periodic structure with characteristic scale (116 ± 10) h−1 Mpc.