bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of musculoskeletal disorders and associated risk factors in Canadian university students
Authors: Parto Dorsa Nouri , Wong Arnold YL , Macedo Luciana 
Published: April 2023

Abstract
Background: Musculoskeletal disorders (MSKDs) present a significant burden to health care systems worldwide. Evidence suggests that university students may have unique risk factors for developing MSKDs; however, research on the corresponding prevalence and risk factors of MSKDs in Canadian students is limited.
Methods: Using a multi-year cross-sectional survey, we aimed to understand the prevalence and risk factors of MSKDs in students at McMaster University. A survey on the prevalence of MSKD as well as potential risk factors was conducted online in the years 2018-2022. Our outcomes were the prevalence of MSKDs over the last 7 days and the last 12 months, as well as presence of lower body, upper body, and spine MSKDs. We investigated risk factors using negative binomial regression analysis, including a sex-stratified analysis.
Results: There were a total of 289 respondents in 2018 with a decrease in the number of participants in the subsequent survey years (n2019 = 173, n2020 = 131, n2021 = 76). Participants reported a median of 2-3 pain sites in the last year and 1-2 pain sites in the last week in all four years. The most prevalent sources of self-reported pain were the lower back and neck. Depending on the year and outcome studied, 59-67% of participants reported neck/lower back pain in the last year, and 43-49% of respondents reported it in the last week. Although risk factors were different depending on the year and the sex, overall, poorer mental health, being in health care studies, regular sports participation (males only), older age, and less hours of sleep were significantly associated with higher prevalence of MSKDs.
Conclusions: This identified that MSKDs is a prevalent source of pain in university students. While some risk factors, such as mental health, are known to play a role in developing MSKDs, sports activity and academic pressure are risk factors that are unique to students. Our study also suggests that there may also be differences in risk factors between sexes.
Clinical characteristics and gene mutation analysis of patients with transformed small-cell lung cancer
Authors: Qiu Jiayong , Hao Yingying , Huang Shenshen , Zhu Yingwei , Wang Tongsheng , Mao Yimin , Yuan Yadong 
Published: April 2023

Abstract
Background
Transformed small-cell lung cancer (T-SCLC) is one of the mechanisms by which lung adenocarcinoma (LADC) becomes resistant to treatment with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). However, this phenomenon remains poorly understood. The study aims to analyze the clinical features and gene mutation characteristics of T-SCLC patients in our hospital.
Methods
Clinical data were collected from 2013–2022 on patients with the initial diagnosis of LADC treated with EGFR-TKIs followed by re-biopsy case type transform into SCLC in our hospital, and their clinical features, tumor pathology, gene mutation characteristics, clinical treatment, and prognosis were analyzed.
Results
A total of 6 (6/362, 1.7%) patients with T-SCLC who were all initially diagnosed with LADC and all had EGFR 19 or 21 mutation, the same mutation status as after transformation, as well as combined RB1, TP53, PIK3CA, PTEN, FGFR, YES1 mutation. The mean progression-free survival after EGFR-TKIs treatment was 33.3 months (IQR, 28.8–37.5 months), compared to 3.6 months (IQR, 2.6-5.0 months) after T-SCLC. 4 cases transformed to SCLC and 2 cases to compound SCLC after TKIs treatment; the mean increase in Neuron-specific enolase (NSE) after conversion was 11.6-fold. The follow-up first-line treatment regimen was etoposide-platinum in all cases. There are currently 3 cases of survival and 3 deaths, with a mean overall survival of 51.7 months (IQR, 42.8–60.5 months).
Conclusions
LADC may transform into SCLC after the failure of EGFR-TKIs. Dynamic NSE changes should be monitored and aggressive re-biopsy should be performed to clarify the mechanism of drug resistance. Multidisciplinary treatment should be provided for T-SCLC, and an integrated treatment strategy based on chemotherapy, Anlotinib and radiotherapy should be considered to improve the prognosis.
Evaluation of the aggressive degree of the chemical components to concrete
Authors: Doan Thy Truc 
Published: April 2023

Abstract
Evaluation and research on the aggressive degree to concrete were done in the previous research. However, the evaluation of aggressive certain degree in water to the concrete was evaluated comprehensively by the Viet Nam Standard “TCVN 3994:1985” and ISO 14911:1998. The results presented “water with chemical characteristics can’t create the aggression in concrete”, which shows pH concentration is 5 and CO2 corrosion is 20 mg/l; whereas ion Mg2+ is 1.5 g/l and SO42− is 0,25 g/l. The total salt content in the presence of evaporating surface obtains 12,5g/l. On the other hand, this paper considers water with the chemical name “Chlorite-Bicarbonate-Sodium-Magnesium” by the Kurlov formula and “TCVN 81:1981”. Especially, comprehensive consideration of chemical analysis that includes Cation (Ca2+; Mg2+; ∑(Fe2+; Fe3+; Na+; K+; and NH4+); Anion (Cl−; SO42−; HCO3−; CO32− and OH−); and the other special items analysis which includes Permanent and Temporary hardness; Alkalinity; CO2 free; CO2 corrosive; Total mineralization; pH value; Nitrite (NO2−); and Nitrate (NO3−). So research results can be used safely for the design or construction of the reinforcement concrete structures in My Thai Canal Bridge, Rach Gia town, Kien Giang province, Viet Nam, and Construction or Geotechnical as good reference documents in the future.
Diagnostic performance of metagenomic next-generation sequencing for Pneumocystis jirovecii pneumonia
Authors: Xuefang Li , Li Zhijun , Ye Jian , Ye Wu 
Published: April 2023

AbstractObjective Pneumocystis jirovecii pneumonia (PJP) can be a life-threatening opportunistic infection. We aimed to include eligible clinical studies to evaluate the diagnostic accuracy of metagenomic next-generation sequencing (mNGS) for PJP. Methods A comprehensive electronic literature search of Web of Knowledge, PubMed, Cochrane Library, CNKI, and Wanfang data was performed. Bivariate analysis was performed to calculate the pooled sensitivity, specificity, diagnostic odds ratio (DOR), the area under the summary receiver operator characteristic (SROC) curve and the Q-point value (Q*). Results The literature search resulted in 9 studies with a total of 1343 patients, including 418 cases diagnosed with PJP and 925 controls. The pooled sensitivity of mNGS for the diagnosis of PJP was 0.974 [95% confidence interval (CI), 0.953–0.987]. The pooled specificity was 0.943 (95% CI, 0.926–0.957), the pooled DOR was 431.58 (95% CI, 186.77-997.27), the area under the SROC curve was 0.987, and the Q* was 0.951. TheI2test showed no heterogeneity between studies. The Deek funnel test suggested no potential publication bias. Subgroup analyses indicated that the area under the SROC curve of mNGS for diagnosis of PJP in immunocompromised and non-HIV patients was 0.9852 and 0.979, respectively. Conclusions Current evidence indicates that mNGS exhibits excellent accuracy for the diagnosis of PJP. mNGS is a promising tool for assessment of PJP in immunocompromised and non-HIV patients.
Study on the relationship between the choroidal thickness and hormone levels with central serous chorioretinopathy
Authors: Shen Jing , Xie Bing , Cai Shanjun , LI Hong , Su Gang 
Published: April 2023

Abstract
Objective To investigate whether the choroidal thickness in central serous chorioretinopathy is related to endogenous hormone levels.
Methods A case-control study. From July 2020 to October 2021, 60 male patients diagnosed with central serous chorioretinopathy at the ophthalmology clinic of the affiliated Hospital of Zunyi Medical University, and 60 healthy, young and middle-aged men were collected as the control group. There were 53 cases of acute CSC (106 eyes) and 7 cases of chronic CSC (14 eyes). The study and control groups' smoking, drinking, and sleeping habits were compared statistically, and BCVA, intraocular pressure, and eye axis were assessed. The macular choroidal thickness was measured by enhanced depth imaging-optical coherence tomography (EDI-OCT) from 2 to 5 p.m, measured at the subfoveal choroidal thickness (SFCT), above the fovea, below, nasal and temporal 750 μm, and the average macular choroidal thickness was the average of the five sites. Blood samples were taken from the control and study groups corresponding to the measuring time, and the levels of adrenaline, norepinephrine, dopamine, cortisol, aldosterone, total testosterone and estradiol were measured by radioimmunoassay. The Chi-square test was used in univariate analysis. Spearman correlation analysis was used to analyze the correlation between continuous numerical variables which did not obey normal distribution. The independent variables of p value < 0.05 in univariate analysis were included in multiple linear regression analysis.
Results 1. There was no significant difference in age, smoking, drinking and sleep habits between the study group and the control group (p=0.053, 0.099, 0.079, 0.095). 2. There were significant differences in the average choroidal thickness between the affected eyes and the contralateral eyes in the study group and the control group (p＜0.05). There was no significant difference in the average macular choroidal thickness between the affected eyes and the contralateral eyes in the study group (p>0.05). 3. The levels of norepinephrine and total testosterone in the study group were significantly different from those in the control group (p< 0.05). 4. There was a positive correlation between the average macular choroidal thickness and norepinephrine and total testosterone (p<0.001, r=0.348, r=0.446).
Conclusion Average choroidal thickness in macular area of CSC eyes and contralateral eyes increased. Norepinephrine and total testosterone are the main factors affecting the average choroidal thickness in macular area of CSC.
Lifelong effects of prenatal and early postnatal stress on the hippocampus, amygdala, and psychology of Holocaust survivors
Authors: Fňašková Monika , Říha Pavel , Nečasová Markéta , Preiss Marek , Rektor Ivan 
Published: April 2023

Abstract
In this study, we examine the effect of age on hippocampal and amygdala stress damage in Holocaust survivors, with an emphasis on prenatal and early postnatal development. We investigated people who lived in Central Europe during the Holocaust and who, as Jews, were in imminent danger. A group who experienced stress during their prenatal development and early postnatal (PreP) period (n = 11) were compared with a group who experienced Holocaust-related stress later in their lives: in late childhood, adolescence, and early adulthood (ChA) (n = 21). The results of volumetry analysis showed significantly lower volumes of both hippocampi and the right amygdala in the PreP group. Seed-based connectivity analysis revealed increased connectivity from the left hippocampus to the thalami and caudate and from the seed in the right amygdala to the middle and posterior cingulate cortex, caudate, and left frontal operculum inferior in the PreP group. Psychological testing found higher levels of traumatic stress symptoms (TCS-40) and lower levels of well-being (SOS-10) in the PreP group than in the ChA group. The results of our study demonstrate that extreme stress experienced during prenatal and early postnatal life has an irreversible lifelong impact on the hippocampus and amygdala and on some psychological characteristics of Holocaust survivors.
Neonatal outcomes when intravenous esketamine is added to the parturients transferred from labor analgesia to emergency cesarean section: A retrospective analysis report
Authors: Liang Zhaojia , Zhou Ting , Li Yalan , Wang Mengxia 
Published: April 2023

Abstract
Objectives
The use of intravenous (i.v.) analgesics during emergency cesarean section with epidural anesthesia (EA) can lead to adverse neonatal outcomes. The purpose of our study was to investigate whether administering a single i.v. dose of 25 mg esketamine to parturients suffering from inadequate analgesia before delivery would affect the neonate in the presence of epidural anesthesia for cesarean section.
Design:
We reviewed the records of parturients who, after receiving labor analgesia, failed to deliver their neonates and turned into cases of emergency cesarean section with EA from January 2021 to April 2022. Parturients were grouped by whether they received esketamine infusion during the incision–delivery interval. Neonatal outcomes, including umbilical arterial-blood gas analysis (UABGA), Apgar score, and total days spent by the neonate in the hospital, were compared between the two groups.
Setting
: China
Results
After propensity score matching, 32 patients remained in each of the non-esketamine and esketamine groups. There were no significant differences in neonatal outcomes, including UABGA, Apgar score, and total days in the hospital, between the two groups.
Conclusions
Intravenous esketamine (25 mg) is safe for neonates when it is given to parturients transferred from labor analgesia to emergency cesarean section.
Ergonomic hands-on performance on Gynecological laparoendoscopic single-site (LESS) surgery
Authors: Yang Ye , Pan Yu Qin , Lu Qi , Wang Min , Liu Wei , Bao Wei , Wu Su Fang 
Published: April 2023

Abstract
Background: Few previous studies have introduced general techniques to overcome the “chopstick effect” in laparoendoscopic single-site surgery (LESS). We aim to investigate and highlight the key ergonomic methodologies for gynaecologic LESS based on the surgeon's hands-on performance.
Methods: The first author surgeon A reviewed and analyzed the LESS procedures performed by herself and how she taught surgeon A B, from January 2021 to April 2022. The procedures were classified based on technical difficulty and learning periods, and the hands-on technical skills of the surgeons during the LESS module were evaluated.
Results: Surgeon A conducted 580 LESS procedures, which were divided into the novice (n=48) and intermediate (n=33) periods, and the remaining cases were included in the routine period. We took ergonomic aspects into account and formed a special ergonomic LESS operating methodology: 1 Maintain good LESS laparoscopic spatial sensation, keep hand-eye coordination, well cooperation between the main surgeon and the assistant; 2 Improve basic LESS technique: grasp, lift, transfer and place objects, and proficient in blunt separating, coagulation, cutting and handling produce. 3 Coordination location, orientation, movements, functions, and flexion or extension of shoulders, arms, elbow, wrist and finger joints; 4 Maintain strength, tension, ambidexterity, depth perception, continuous postures and repetition with joint and muscular efforts to control instruments. 5 Experienced multiport laparoscopy surgery (MPS) skills on basic surgical proceduresand familiarity with anatomical structures were also determining elements. Surgeon B learned the above experiences by performing 39 LESS procedures under the guidance of surgeon A.
Conclusion: This educational research sheds light on the common challenges faced in LESS and presents the importance of ergonomic hands-on performance skills in improving surgical outcomes. The findings could serve as a guide for future training and education in LESS.
Multidrug-resistant bacteria may be associated with bed allocation and utilization efficiency in healthcare institutions, based on national monitoring data from China (2014– 2020)
Authors: Wang Xing-Tian , Pan Dong-Feng , Lu Wen-Wen , Chen Chen , Su Ming , Meng Hua , Su Xin-Ya , Liu Zhuo , Ma Xiao-Juan , Liang Pei-Feng 
Published: April 2023

Abstract
Multidrug-resistant bacteria have become one of the most paramount health perils in the 21st century. In this study, provincial-level panel data in China were used to analyze the relationship between bed allocation, utilization efficiency, and MDROs detection rates by the panel data quantile regression model. It was shown that the number of beds per 1,000 people had a negative effect on the detection rate of MRSA, VREA, VREM, PRSP, MRCNS, and CTX/CRO-R ECO (regression coefficient < 0, P < 0.05). The hospital bed utilization rate had a positive effect on the detection rate of MRSA, MRCNS, VREM, PRSP, CTX/CRO-R ECO, CR-ECO, CTX/CRO-R KPN, CR-KPN, CR-PAE, and CR-ABA (regression coefficient > 0, P < 0.05). The average hospital stay had a positive effect on the detection rate of MRSA, MRCNS, VREA, VREM, PRSP, CTX/CRO-R ECO, CR-ECO, QNR-ECO, CTX/CRO-R KPN, CR-PAE, and CR-ABA (regression coefficient > 0, P < 0.05). MDROs are associated with bed allocation and utilization efficiency in healthcare institutions. The Department of Medical Administration should reduce the incidence of MDROs by increasing bed medical allocation and improving the efficiency of bed utilization in hospitalized patients.
C-reactive Protein is a Strong Prognostic Factor for Overall Survival in Clinically Node-positive Patients with Upper Tract Urothelial Carcinoma
Authors: Sasahara Taishiro , Yanagisawa Takafumi , Sugaya Shingo , Hisakane Akira , Sakanaka Keigo , Hara Shuhei , Otsuka Takashi , Takamizawa Shigeaki , Yata Yuji , Takahashi Yusuke , Takiguchi Yuki , Mori Keiichiro , Tsuzuki Shunsuke , Kimura Shoji , Miki Jun , Kimura Takahiro 
Published: April 2023

Abstract
Background
There is sparse evidence regarding optimal management and prognosticators for oncologic outcomes in patients with clinical node positive (cN+) upper tract urothelial carcinoma (UTUC).
Methods
We retrospectively analyzed the data from 105 UTUC patients with cN1-2M0 between June 2010 and June 2022 at multiple institutions affiliated with our university. At the time of diagnosis, all patients received standard-of-care treatment including radical nephroureterectomy (RNU), chemotherapy, and/or palliative care. We employed a Cox regression model to analyze the prognostic importance of various factors on overall survival (OS).
Results
Of 105 patients, 54 (51%) underwent RNU, while 51 (49%) did not. RNU was likely to be selected in younger and healthy patients, resulting in better median OS in patients who underwent RNU than in those who did not (42 months vs. 15 months, p < 0.001). Multivariable analysis among the entire cohort revealed that low G8 score (≤ 14) (hazard ratio [HR]: 2.20, 95% confidence interval [CI]: 1.15–4.23), elevated pretreatment C-reactive protein (CRP) (HR: 3.28, 95%CI: 1.59–6.76), and failure to perform RNU (HR: 2.27, 95%CI: 1.11–4.76) were independent prognostic factors for worse OS. In the subgroup analyses of cohorts who underwent RNU and those who did not, elevated pretreatment CRP was the only common independent prognostic factor for worse OS in cN + UTUC patients.
Conclusions
RNU seems to be a reasonable treatment option in cN + UTUC patients where applicable. Elevated pretreatment CRP appears to be a strong prognosticator of worse OS and may be helpful in optimizing candidate selection for intensified treatment in this setting.
Caloric restriction prevents inflammation and insulin dysfunction in middle-aged ovariectomized mice
Authors: Sapatini Leticia Roberta , Calsa Bruno , Marim Laís Jorge , Helaehil Julia Venturini , Chiarotto Gabriela Bortolança , Amaral Maria 
Published: April 2023

Abstract
Background
Loss of ovarian function is associated with increased visceral fat. In this study, we aimed to study the effects of caloric restriction (CR) on metabolism in ovariectomized mice.
Methods and Results
Female, 8–12-month-old mice were divided into three groups: OVX (ovariectomized mice), OVXR (40% CR) and Sham. CR increased insulin sensitivity and glucose tolerance. AMPK phosphorylation was observed in the liver of OVXR mice. CR also increased hepatic cholesterol and triglyceride levels. The reductions in the level of TBARS in the serum and liver and of H2O2 in the liver of OVXR mice suggested alterations in the redox state of the liver. Although expression of catalase protein was reduced by CR, expression of superoxide dismutase was not altered by CR. Although interleukin IL-6 and IL-10 levels in OVXR mice were similar to those in Sham mice, macrophage infiltration was reduced in OVXR mice. OVXR mice had increased sirtuin1 levels and decreased sirtuin3 levels in the liver.
Conclusions
In conclusion, CR improved the condition of ovariectomized mice by reducing adiposity and increasing insulin sensitivity and glucose tolerance through a mechanism that may involve AMPK.
A Hybrid Convolution Neural Network with Channel Attention Mechanism for Sensor-Based Human Activity Recognition
Authors: Mekruksavanich Sakorn , Jitpattanakul Anuchit 
Published: April 2023

Abstract
Research studies in machine intelligence and ubiquitous computing have become increasingly intrigued by human activity recognition based on wearable sensors. In recent decades, various learning-based approaches have been significantly applied for human activity recognition to determine successful models for identifying human behaviors. Because of the robust feature extraction abilities of deep learning algorithms, their conveniently extracted features acquire excellent detection capability. Nevertheless, most accomplished deep learning approaches have been established for complicated models with several hyperparameters. This paper investigates the present human activity recognition study on deep learning techniques and discusses appropriate recognition strategies. First, we utilized many convolutional neural networks to determine the effective architecture of human activity recognition. Subsequently, we designed a hybrid convolutional neural network that was implanted with a channel attention mechanism to capture deep spatio-temporal characteristics hierarchically and differentiate human movements in everyday life. Investigations on the UCI-HAR and WISDM datasets revealed that our suggested model, which included cross-channel multi-size convolution transformation, surpassed previous deep learning structures with 98.92% and 98.80% accuracy, respectively. The proposed model outperforms state-of-the-art approaches in terms of total accuracy, as indicated by the research findings.