bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is tumor necrosis a clinical prognostic factor in hepato‐biliary‐pancreatic cancers? A systematic review and meta‐analysis
Authors: Yang Siqi , Hu Haijie , Hu Yafei , Dai Yushi , Zou Ruiqi , Lv Tianrun , Li Fuyu 
Published: March 2023

AbstractBackgroundIt has been proven that tumor necrosis is associated with poor prognoses in various solid malignant tumors. However, the prognostic effect of tumor necrosis in hepato‐biliary‐pancreatic cancers is still unclear. Therefore, this study was performed to evaluate the associations of tumor necrosis with survival outcomes and clinicopathological features in patients with hepato‐biliary‐pancreatic cancers.MethodsBased on the PRISMA statement, eligible studies were identified from PubMed, Embase, Cochrane Library, and Web of Science from inception until January 2023. The pooled hazard ratios (HRs) and 95% confidence intervals (95%CIs) were calculated to assess the connection between tumor necrosis and hepato‐biliary‐pancreatic cancers. We then choose which effects model to use to generate pooled HRs and 95% CIs, depending on data heterogeneity.ResultsIn total, 6497 articles were identified, 10 of which were included in this meta‐analysis. Our results suggested that the presence of tumor necrosis predicted a poorer outcome for overall survival (HR = 1.54, 95% CI = 1.35–1.77, p < 0.001) and recurrence‐free survival (HR = 1.69, 95% CI = 1.37–2.08, p < 0.001). In addition, tumor necrosis was correlated with larger tumor size, a higher frequency of lymph node metastasis, poorer histologic differentiation, and higher recurrence and metastasis rates.ConclusionOur meta‐analysis suggests that hepato‐biliary‐pancreatic cancer patients with tumor necrosis have dismal survival outcomes, and that their tumors have aggressive biological behaviors. Tumor necrosis has the potential to be a promising biomarker for forecasting poor prognosis in these patients.
Burden of cancers attributable to high fasting plasma glucose in the Middle East and North Africa region, 1990–2019
Authors: Tondro Anamag Farhad , Noori Maryam , Nejadghaderi Seyed Aria , Sullman Mark J. M. , Grieger Jessica A. , Kolahi Ali‐Asghar , Safiri Saeid 
Published: March 2023

AbstractBackgroundThe present study reported the cancer deaths and disability‐adjusted life years (DALYs) that were attributable to high fasting plasma glucose (HFPG) in the Middle East and North Africa (MENA) region by country, age, sex, cancer type and Socio‐demographic Index (SDI), from 1990 to 2019.MethodsGlobal Burden of Disease (GBD) 2019 data were used to report the cancer‐related deaths and DALYs that were attributable to HFPG, for all MENA countries over the period 1990–2019. The results were presented as numbers, population attributable fractions (PAFs) and rates (per 100,000) with 95% uncertainty intervals.ResultsIn 2019, there were an estimated 19.8 thousand (5.5–40.2) cancer deaths attributable to HFPG in MENA, which represents 4.7% (1.3–9.3) of all cancer‐related deaths. The number of regional DALYs due to HFPG‐related cancers was 462.2 thousand (127.3–959.5), which represents 3.8% (1.1–7.6) of all cancer‐related DALYs in 2019. From 1990 to 2019, the age‐standardized DALY rate of cancers attributable to HFPG (per 100,000) grew from 56.3 (14.6–121.1) to 107.0 (29.8–220.8), which was a 90.1% (64.4–127.8) increase. In 2019, the highest age‐standardized DALY rate of cancers attributable to HFPG was in Qatar (270.4) and the lowest was in Sudan (75.3). The DALY rate of cancers attributable to HFPG increased with age, peaking for males in the 70–74 age group and for females in the 75–79 age group, and then decreased for both sexes. A broadly positive relationship was found between the national SDI and the national age‐standardized DALY rate of all cancers attributable to FPG over the measurement period.ConclusionsThe burden of HFPG‐related cancers has increased over the past three decades in MENA, and was higher than the global average in multiple age groups. Implementing a battery of preventive measures and therapeutic interventions is suggested to address the adverse effects of this modifiable risk factor.
Impact of age, antiretroviral therapy, and cancer on epigenetic aging in people living with HIV
Authors: Qing Yulan , Chan Ricky , Fu Pingfu , Cullen Jennifer , Miron Alexander , Jacobson Jeffrey M. , Pink John , Gerson Stanton L. 
Published: March 2023

AbstractBackgroundPremature aging has been identified as a global risk factor for cancer. Causes of premature aging are multifactorial, including inflammation, infection, chronic stress, and lifestyle factors.MethodWe evaluated whether premature aging in people living with HIV (PLWH) was associated with antiretroviral therapy (ART) or the diagnosis of cancer. We used well‐established DNA methylation patterns to assess premature aging, using Horvath et al., in individuals with HIV located in Cleveland, Ohio and compared these to standardized datasets of US historical blood samples. Some of the PLWH developed cancer over time.ResultsWe found that DNA methylation analysis identified accelerated aging in PLWH whereas ART therapy mitigated the advancement of DNA methylation age. A variety of cancers were observed in this population, but a cancer diagnosis was not significantly associated with more advanced DNA methylation age.ConclusionWe find that the age acceleration detected in PLWH is mitigated by ART therapy and is not further accelerated by a diagnosis of cancer.
Long‐term survivors with desmoplastic small round cell tumor (DSRCT): Results from a retrospective single‐institution case series analysis
Authors: Giani Claudia , Radaelli Stefano , Miceli Rosalba , Gandola Lorenza , Sangalli Claudia , Frezza Anna Maria , Provenzano Salvatore , Pasquali Sandro , Bertulli Rossella , Fiore Marco , Callegaro Dario , Casanova Michela , Chiaravalli Stefano , Collini Paola , Dagrada Gian Paolo , Morosi Carlo , Zaffaroni Nadia , Casali Paolo G. , Ferrari Andrea , Gronchi Alessandro , Stacchiotti Silvia 
Published: March 2023

AbstractObjectiveTo report on a retrospective study of primary DSRCT aiming at characterizing long‐term survivors (LTS).MethodsAll consecutive patients treated at our institution for a primary DSRCT between 2000 and 2021 were retrospectively identified. Patients received multiagent chemotherapy ± surgery ± hyperthermic intraperitoneal chemotherapy (HIPEC) ± whole abdomino‐pelvic radiotherapy (WAP‐RT) ± high‐dose chemotherapy ± maintenance chemotherapy (MC). Event‐free survival (EFS) and overall survival (OS) were estimated by Kaplan–Meier method. Patients alive, without evidence of disease at ≥36 months from diagnosis, were defined as LTS.ResultsThirty‐eight patients were identified. All received multiagent chemotherapy; 27/38 (71%) surgery (7/27 [26%] plus HIPEC), 9/38 (24%) WAP‐RT, 12/38 (32%) MC. At a median‐follow‐up of 37 months (IQR 18–63), overall median‐EFS and median‐OS were 15 and 37 months, respectively. All events occurred within 35 months. In patients who underwent surgery, median‐EFS and median‐OS were 19 and 37 months (23 and 43 months after R0/R1, and 10 and 19 months after R2 resection), respectively. LTS were 5/38 (13%), alive at 37, 39, 53, 64, 209 months. None had liver or extra‐abdominal metastasis at diagnosis, they all received R0/R1 resection, 3/5 had WAP‐RT, 2/5 MC, 1/5 received high‐dose chemotherapy, none HIPEC.ConclusionsIn our series cure was likely achieved in 13% of DSRCT. LTS had no liver/extra‐abdominal disease, were treated with complete surgery, and possibly WAP‐RT/MC.
Effect of local treatment in patients with oligo‐recurrence after surgery of distal bile duct cancer: A bi‐institutional study
Authors: Yoon So Jeong , Hong Seung Soo , Gwon Min Jae , Shin Sang Hyun , Heo Jin Seok , Kang Chang Moo , Kim Kyung Sik , Hwang Ho Kyoung , Han In Woong 
Published: March 2023

AbstractBackgroundDistal extrahepatic bile duct (EHBD) cancer is highly recurrent. More than 50% of patients suffer from disease relapse after curative resection. Some patients present with oligo‐recurrence which could be a single loco‐regional mass or lesions limited to a single solid organ. The aim of this study was to examine the effect of local control (surgical resection or radiofrequency ablation) on survival outcomes in patients with oligo‐recurrent distal EHBD cancer.MethodsData of 1219 patients who underwent surgery for distal EHBD cancer from 2000 to 2018 were retrospectively reviewed. Clinicopathological characteristics and survival outcomes of patients with recurrence were investigated. Post‐recurrence survival (PRS) was analyzed according to modalities of re‐treatment (local treatment or systemic therapy alone).ResultsAmong 654 patients with recurrence, 90 patients who had oligo‐recurrence showed better recurrence‐free and overall survival than patients with non‐oligo‐recurrent disease. Lymph node ratio and perineural invasion at initial pathology, timing of recurrence, and platelet‐to‐lymphocyte ratio at recurrence were independent risk factors for PRS in the oligo‐recurrent group. Patients with local treatment for oligo‐recurrence had better 3‐ and 5‐year PRS than those with systemic treatment alone (38.3% vs. 14.1%, p = 0.04; 28.3% vs. 7.1%, p = 0.04, respectively). Recurrence within 24 months after initial surgery was the only significant factor for PRS in the local treatment group.ConclusionIn patients with oligo‐recurrence after resection of distal EHBD cancer, post‐recurrence local treatment could improve survival outcomes, particularly for those with recurrence more than 2 years after initial resection.
Who is willing to help Ukrainian refugees and why? The role of individual prosocial dispositions and superordinate European identity
Authors: Politi Emanuele , Gale Jessica , Roblain Antoine , Bobowik Magdalena , Green Eva G.T. 
Published: March 2023

AbstractIn 2022, Europe experienced unprecedented citizen mobilizations to help Ukrainian refugees. Based on two parallel lines of scholarship, we examined individual prosocial dispositions and superordinate identities related to intentions to help Ukrainians. Employing a French‐speaking student sample in Belgium (N = 374), in Study 1, we showed that dispositional prosociality and European identification were both positively related to intentions to help Ukrainians. An interaction qualified these main effects, so that highly prosocial European identifiers were particularly willing to help. With a nationwide quota sample of the French‐speaking population in Belgium (N = 371), in Study 2, we identified two processes mediating the relationship of dispositional prosociality and European identification with intentions to help Ukrainians. On the one hand, dispositional prosociality was positively related to empathy with Ukrainians, which in turn predicted participants' helping intentions. On the other hand, European identification was positively related to both empathy and identity fusion with Ukrainians, which further predicted participants' helping intentions. Overall, these findings suggest that individual prosocial dispositions and superordinate identities represent two cumulative pathways to intergroup helping. Concluding, we discuss common and specific processes related to intentions to help Ukrainians, compared with other refugee groups.
Chemoproteomics Reveals That Quaternary Protoberberine Alkaloids Inhibit Telomerase Activity Oncologically by Binding to PES1
Authors: Xu Ling‐Wen , Zhang Xue‐Qian , Yan Zheng , Li Zhi‐Hong , Deng An‐Jun , Qin Hai‐Lin 
Published: March 2023

AbstractNatural QPAs have anti‐cancer property. The prodrugs of QPAs synthesized in our work with significantly improved solubility showed significantly stronger activity in animal experiments. Nevertheless, the mechanism of action of QPAs for treating cancers remains poorly understood. Here, a chemoproteomic study reveals that QPAs non‐covalently and multivalently bind to PES1 in CRC cells, which impinges on the direct interaction between hTERT and hTR in the assembly of the telomerase complex, downregulates telomerase activity, and so promotes the aging process of CRC cells. This study is beneficial for us to conduct extensively the pharmaceutical chemistry research of QPAs.
HIF‐1α‐induced upregulated miR‐322 forms a feedback loop by targeting Smurf2 and Smad7 to activate Smad3/β‐catenin/HIF‐1α, thereby improving myocardial ischemia‐reperfusion injury
Authors: Dong Wei , Dong Chen , Zhu Jianbing , Zheng Yaofu , Weng Junfei , Liu Leilei , Ruan Yang , Fang Xu , Chen Jin , Liu Wenyu , Peng Xiaoping , Chen Xuanying 
Published: March 2023

AbstractMyocardial ischemia/reperfusion injury (MIRI) is a major cause of heart failure after myocardial infarction. It has been reported that miR‐322 is involved in MIRI progression, while the molecular mechanism of miR‐322 in regulating MIRI progression needs to be further probed. MIRI cell model was established by oxygen‐glucose deprivation/reoxygenation (OGD/R). Cell viability was assessed using MTS assay. Flow cytometry and terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling staining were employed to analyze cell apoptosis. In addition, the interactions between miR‐322, Smad7/Smurf2, hypoxia‐inducible factor alpha (HIF‐1α), and β‐catenin were verified by dual‐luciferase reporter gene assay. Our results displayed that miR‐322 was significantly downregulated in OGD/R‐treated H9c2 cells, and its overexpression resulted in increased cell viability and reduced the apoptosis. Smurf2 and Smad7 were identified as the direct targets of miR‐322. Smad7 knockdown or Smurf2 knockdown increased OGD/R‐treated H9c2 cell viability and suppressed the apoptosis. Meanwhile, miR‐322 mimics abolished the mitigating effect of Smad7 or Smurf2 overexpression on MIRI. In addition, the Smad3/β‐catenin pathway was identified as the downstream pathway of Smurf2/Smad7. Moreover, it was found that HIF‐1α interacted with the miR‐322 promoter, and β‐catenin interacted with the HIF‐1α promoter to form a loop. HIF‐1α‐induced upregulated miR‐322 activated the Smad3/β‐catenin pathway by targeting Smurf2 and Smad7 to improve MIRI; meanwhile, β‐catenin/HIF‐1α formed a positive feedback loop to continuously improve MIRI.
Ormeloxifene, a nonsteroidal antifertility drug promotes megakaryocyte differentiation in leukemia cell line K562
Authors: Mishra Mukul , Singh Anil Kumar , Thacker Gatha , Upadhyay Vishal , Sanyal Sabyasachi , Trivedi Arun Kumar 
Published: March 2023

AbstractOrmeloxifene (ORM) (3,4‐trans‐2,2‐dimethyl‐3‐phenyl‐4‐p‐(β‐pyrrolidinoethoxy) phenyl‐7‐methoxychroman), world's first nonsteroidal selective estrogen receptor modulator approved for contraception in India has been shown to have potential anticancer activities. Here, we show that ORM can induce megakaryocyte and myeloid (granulocytic) but not erythroid differentiation in multipotent human myeloid leukemia cell line K562. We show that ORM at an IC50 of 7.5 µM can induce morphological changes similar to megakaryocytes in K562 cells. ORM led to increase in levels of megakaryocytic differentiation markers (CD41 and CD61) as well as key transcription factors GATA1 and AML1. We further show that ORM induces megakaryocytic differentiation in K562 cells through ERK activation and induction of autophagy in a fashion similar to other known inducers of megakaryocytic differentiation such as phorbol esters. In addition, as shown earlier, we yet again observed that ORM led to activation of caspases since their inhibition through pan‐caspase inhibitor mitigated megakaryocytic differentiation as they led to significant decrease in CD41 and CD61. Because induction of megakaryocytic differentiation in K562 involves growth arrest and exit from cell cycle, we also observed an increase in levels of p21 and p27 with decrease in c‐Myc protein levels in K562 cells treated with 7.5 µM ORM for 24 and 48 h, respectively. Taken together, these findings indicate that ORM can markedly induce megakaryocytic differentiation in K562 cells.
Vascular closure after transfemoral transcatheter aortic valve replacement: Further randomized trials are justified
Authors: Hillegass William B. 
Published: March 2023

Key Points
Major vascular complications (MVCs) occur in approximately 4% of contemporary transcatheter aortic valve replacements (TAVR) often related to large bore transfemoral access and vascular closure.
Plug‐based vascular closure appears to have non‐significantly lower risk of MVCs in 8 observational studies while suture‐based devices have non‐significantly lower MVCs in the 2 randomized trials.
Given the frequency of TAVR and the consequences of MVCs, larger randomized trials may better inform patient, procedural, and operator/institutional specific choice of vascular closure device.
Bioplastic film making properties of quality protein maize (QPM) zein
Authors: Baloyi Julia T. , Taylor Janet , Taylor John R. N. 
Published: March 2023

AbstractBackground and ObjectiveQuality protein maize (QPM) has abundant γ‐zein, which crosslinks itself and other zeins through disulfide bonding. The work aims to develop zein bioplastics with better functionality by using QPM zein. Physical properties of cast QPM zein films from QPM maize were compared with zein films from regular maize types and commercial zein, all without added plasticizers.FindingsQPM zein contained 3.8% cysteine compared with 1.8%–2.7% in regular maize zeins and 1% in commercial zein and the QPM zein had a much higher proportion of γ‐zein. QPM zein films cast from glacial acetic acid (GAA) were opaque but absorbed the least liquid (≈16%) and swelled less (≈11%) after buffer immersion than the other zein films and aqueous ethanol‐cast films. Notably, the GAA‐cast QPM zein films became highly flexible after ambient storage, whereas the other zein films remained brittle.ConclusionsThe low buffer uptake and swelling of QPM zein films is attributed to crosslinking involving the cysteine‐rich γ‐zein polypeptides. Their flexibility is attributed to better solubilization of the zein in GAA and water molecules bound to the γ‐zein polypeptides acting as a plasticizer.Significance and NoveltyQPM zein can enable the formation of flexible zein bioplastics without added plasticizers.
Exploring Zr‐Based Metal‐Organic Frameworks as Smart Electrochromic Sensors by Coordination‐Driven Surface Engineering
Authors: Huang Shan , Liu Ying , Huang Pengcheng , Wu Fang‐Ying , Mao Lanqun 
Published: March 2023

AbstractAs emerging stimuli‐responsive materials, electrochromic metal‐organic frameworks (MOFs) are still not utilized in sensing applications due to difficulties in water stability, facile synthesis and functionalization, and efficient translation of specific recognition events. Here, we firstly find that a Zr‐based MOF furnished with postsynthetically created viologen‐like electron‐deficient moiety was electrochromic active. With a coordination‐driven surface engineering strategy where phosphate‐containing biomolecules are tethered to Zr nodes of the MOF, fine tuning the interface electron transfer was readily achieved, thus benefitting for constructing smart electrochromic sensors through the combination of the sensitivity of electrochemistry with the visuality of colorimetry. Particularly, MOF‐coated conductive films enabled label‐free detection of phosphoproteins, and aptamer‐functionalized ones responded specifically to the target. In two cases distinct color changes allow for visual quantification. This study represents the first example of MOF‐based electrochromic sensors developed by an efficient strategy, indicating the generality to electrochromic counterparts for various sensing applications.
Stereochemical Control of Secondary Benzamide‐based BODIPY Emitters
Authors: Waly Sara M. A. , Benniston Andrew C. , Karlsson Joshua K. G. , Dixon Casey M. , Wills Corinne , Waddell Paul G. , Harriman Anthony 
Published: March 2023

AbstractAromatic amides can be used to construct light‐harvesting materials with valuable optical properties. The amide bond is formed using well‐known coupling agents in near quantitative yield, as illustrated here through the synthesis of two boron dipyrromethene derivatives bearing an amide linkage. The primary concern with acyl amides is rotation around the C−N bond, leading to cis and trans isomers. Using NMR spectroscopy, quantum chemical calculations and critical comparison to simpler benzamides, the stereochemistry of the target compounds has been addressed. The N‐cyclohexyl derivative gave diffraction quality crystals that established a trans geometry for the amide bond. Quantum chemical calculations support the trans geometry as being the lowest‐energy structure in solution but indicate that inversion of the aryl ring is an important structural feature. Indeed, rotation around the C(sp2)−C(aryl) bond has a strong influence on the solution‐phase NMR spectra. The amide connection has minimal effect on the photophysical properties.
A Template‐Free Pd2L4Cage with up to Nanomolar Affinity for Chloride in Aqueous Solutions**
Authors: Sivalingam Vellaiyadevan , Krishnaswamy Shobhana , Chand Dillip Kumar 
Published: March 2023

AbstractSelective binding of chloride over the other most abundant anions in living organisms is pivotal due to its essential role in physiological functions. Herein, we report a template‐free Pd2L4cage exhibiting high selectivity for medium‐sized halides (i. e., Cl−, Br−) in water owing to the size‐discriminatory nature of the cage cavity. In pure water, this cage displays high selectivity and micromolar affinity for chloride. The cage shows no binding towards other biologically more abundant essential anions such as phosphates, carboxylates, or bicarbonate. This cage shows an unprecedented nanomolar affinity with 1 : 1 binding stoichiometry for chloride in aqueous‐DMSO media. This high affinity was achieved with the best use of traditional hydrogen bonding and electrostatic interactions, as confirmed by single‐crystal X‐ray diffraction analysis. This well‐defined cage sequestrates F−by cleaving a B−F bond in BF4−in a facile manner in a nonpolar solvent or in the presence of excess ligand. This cage also demonstrates capture of the sub‐ppm chloride level that is present in commercial D2O samples.