bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of closed cell self expandable metallic stent for peripheral arterial disease in the porcine iliac artery
Authors: Ryu Dae Sung , Won Dong-Sung , Kim Ji Won , Park Yubeen , Kim Song Hee , Kang Jeon Min , Zeng Chu Hui , Lim Dohyung , Choi Hyun , Park Jung-Hoon 
Published: May 2023

AbstractThis study aimed to investigate the efficacy of a closed-cell self-expandable metallic stent (SEMS) with or without expanded-polytetrafluoroethylene (e-PTFE)-covering membrane in a porcine iliac artery model. Twelve Yorkshire domestic pigs were divided into a bare closed-cell SEMS (B-SEMS) group (n = 6) and covered closed-cell SEMS (C-SEMS) group (n = 6). Both closed-cell SEMSs were placed in the right or left iliac artery. Thrombogenicity score in the C-SEMS group was significantly higher than that in the B-SEMS group (p = 0.004) after 4 weeks. Angiographic findings of mean luminal diameters at 4 weeks follow-up did not differ significantly between B-SEMS and C-SEMS groups. Neointimal hyperplasia thickness as well as degree of inflammatory cell infiltration and collagen deposition in the C-SEMS group was significantly greater than that in the B-SEMS group (p < 0.001). Closed-cell SEMSs successfully maintained patency for 4 weeks without stent-related complications in the porcine iliac artery. Although mild thrombus with neointimal hyperplasia was observed in the C-SEMS group, subsequent occlusion, and in-stent stenosis did not occur in any of the pigs until the end of the study. Closed-cell SEMS with or without the e-PTFE covering membrane is effective and safe for the porcine iliac artery.
Rapidly increasing likelihood of exceeding 50 °C in parts of the Mediterranean and the Middle East due to human influence
Authors: Christidis Nikolaos , Mitchell Dann , Stott Peter A. 
Published: May 2023

AbstractAs the world warms, extremely hot days are becoming more frequent and intense, reaching unprecedented temperatures associated with excess mortality. Here, we assess how anthropogenic forcings affect the likelihood of maximum daily temperatures above 50 °C at 12 selected locations around the Mediterranean and the Middle East. We adopt a risk-based attribution methodology that utilises climate model simulations with and without human influence to estimate the probability of extremes. We find that at all locations, temperatures above 50 °C would have been extremely rare or impossible in the pre-industrial world, but under human-induced climate change their likelihood is rapidly increasing. At the hottest locations we estimate the likelihood has increased by a factor of 10–103, whereas by the end of the century such extremes could occur every year. All selected locations may see 1–2 additional months with excess thermal deaths by 2100, which stresses the need for effective adaptation planning.
Footprints of El Niño La Niña on the evolution of particulate matter over subtropical Island Taiwan
Authors: Fu Yen-Ta , Yen Ming-Cheng , Lin Neng-Huei , Bui-Manh Hai , Lin Cheng-Chih , Yu Jia-Yuh , Peng Chi-Ming , Dinh Duc-Tu 
Published: May 2023

AbstractParticulate matter (PM) pollution has become a major problem worldwide, with significant adverse health impacts, but the climatology of annual variations in and the effect of climate change on PM levels are still not comprehensively evaluated. Here we show that the vertical motions of the East Asian winter and summer monsoons regulate the annual variation in PM over Taiwan. The PM pollution season starts and ends earlier during El Niño episodes than during La Niña episodes. Furthermore, the onset, active, break, revival, and retreat phases of the PM pollution lifecycle are innovatively defined. Our results demonstrate that the annual seasonal cycle dominates wintertime PM pollution climate development during the active phase with a minor modulation by El Niño and La Niña episodes, whereas October and March, the seasonal transition periods, are significantly modulated by these two episodes. The findings suggest a new dimension of PM pollution research—the lifecycle evolution effect.
Split selectable marker systems utilizing inteins facilitate gene stacking in plants
Authors: Yuan Guoliang , Lu Haiwei , De Kuntal , Hassan Md Mahmudul , Liu Yang , Islam Md. Torikul , Muchero Wellington , Tuskan Gerald A. , Yang Xiaohan 
Published: May 2023

AbstractThe ability to stack multiple genes in plants is of great importance in the development of crops with desirable traits but can be challenging due to limited selectable marker options. Here we establish split selectable marker systems using protein splicing elements called “inteins” for Agrobacterium-mediated co-transformation in plants. First, we show that such a split selectable marker system can be used effectively in plants to reconstitute a visible marker, RUBY, from two non-functional fragments through tobacco leaf infiltration. Next, to determine the general applicability of our split selectable marker systems, we demonstrate the utility of these systems in the model plants Arabidopsis and poplar by successfully stacking two reporters eYGFPuv and RUBY, using split Kanamycin or Hygromycin resistance markers. In conclusion, this method enables robust plant co-transformation, providing a valuable tool for the simultaneous insertion of multiple genes into both herbaceous and woody plants efficiently.
Self-organization of ferroelectric domains induced by water and reinforced via ultrasonic vibration
Authors: Yan Shuo , Hu Xueli , Lu Xiaomei , Zhang Junting , Shen Xiaofan , Huang Fengzhen 
Published: May 2023

AbstractPattern formation caused by self-organization is a fascinating phenomenon that appears in biological, chemical, and physical systems. In ferroelectrics, although a variety of domain patterns have been reported at different scales and dimensions, the self-organization process of ferroelectric domains was rarely investigated. Here, in 0.72Pb(Mg1/3Nb2/3)O3−0.28PbTiO3 bulk crystals exposed to water, the self-organized formation process of domain structures is observed and reinforced by ultrasonic vibration. By combining experimental observations and theoretical analysis, we find that adsorbed H+/OH− ions on the sample surface act as screening charges to induce the coarsening of the ferroelectric domains. Meanwhile, interactions among dipoles determine the ordering of the domain configuration, while ultrasonic vibration reduces the barrier height for polarization switching. The process of domain evolution deviates from that of the non-conservative dynamic system, and instead fits a percolation model with a clear transition point. This work demonstrates the self-organization of ferroelectric domains induced by water, which is of value for understanding domain dynamics and for the development of high-performance ferroelectric materials.
Unexpected cold season warming during the Little Ice Age on the northeastern Tibetan Plateau
Authors: Yao Yuan , Wang Lu , Li Xiangzhong , Cheng Hai , Cai Yanjun , Vachula Richard S. , Liang Jie , Li Hanying , Liu Guangxin , Zhao Jingyao , Zhang Haiwei , Li Qiang 
Published: May 2023

AbstractThere is a general agreement that Northern Hemisphere temperatures have cooled over the past two millennia, culminating in the Little Ice Age. However, this understanding partly relies on the compilation of existing proxy records, the majority of which carry a warm season bias such that there is an underrepresentation of cold-season temperatures. Here we report a unique cold-season temperature record based on the alkenone paleothermometer from the northeastern Tibetan Plateau that spans the last two millennia. In contrast to the regional- and hemisphere-scale summer cooling, our reconstruction shows a long-term warming through the Medieval Climate Anomaly into Little Ice Age. We attribute these opposing temperature trends to combined effects of seasonally divergent insolation and North Atlantic subpolar gyre circulation. Our study indicates that the cold season during the Little Ice Age was not the coldest period of the last two millennia at least on the northeastern Tibetan Plateau.
Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters
Authors: Berry Catherine , Pavot Vincent , Anosova Natalie G. , Kishko Michael , Li Lu , Tibbitts Tim , Raillard Alice , Gautheron Sylviane , Cummings Sheila , Bangari Dinesh S. , Kar Swagata , Atyeo Caroline , Deng Yixiang , Alter Galit , Gutzeit Cindy , Koutsoukos Marguerite , Chicz Roman M. , Lecouturier Valerie 
Published: May 2023

Abstract
Background
Since the beginning of the COVID-19 pandemic, several variants of concern (VOC) have emerged for which there is evidence of an increase in transmissibility, more severe disease, and/or reduced vaccine effectiveness. Effective COVID-19 vaccine strategies are required to achieve broad protective immunity against current and future VOC.

Methods
We conducted immunogenicity and challenge studies in macaques and hamsters using a bivalent recombinant vaccine formulation containing the SARS-CoV-2 prefusion-stabilized Spike trimers of the ancestral D614 and the variant Beta strains with AS03 adjuvant (CoV2 preS dTM-AS03) in a primary immunization setting.

Results
We show that a primary immunization with the bivalent CoV2 preS dTM-AS03 elicits broader and durable (1 year) neutralizing antibody responses against VOC including Omicron BA.1 and BA.4/5, and SARS-CoV-1 as compared to the ancestral D614 or Beta variant monovalent vaccines in naïve non-human primates. In addition, the bivalent formulation confers protection against viral challenge with SARS-CoV-2 prototype D614G strain as well as Alpha and Beta variant strains in hamsters.

Conclusions
Our findings demonstrate the potential of a Beta-containing bivalent CoV2 preS dTM-AS03 formulation to provide broad and durable immunogenicity, as well as protection against VOC in naïve populations.
An Fe–Mn–S SOD-like nanozyme as an efficient antibacterial agent
Authors: Fan Xiaowan , Cheng Miaomiao , Ma Saiyu , Song Kexu , Yuan Ye , Liu Yuan 
Published: May 2023

Herein, based on a coordination-precipitation strategy, we have developed a Fe–Mn–S SOD-like nanozyme, which can catalyze the decomposition of ˙O2−and exhibited broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacterium.
Systematic Review of Variables Related to Instruction in Augmentative and Alternative Communication Implementation: Group and Single-Case Design
Authors: Reichle Joe , Pustejovsky James E. , Vannest Kimberly J. , Foster Margaret , Pierson Lauren M. , Wattanawongwan Sanikan , Chen Man , Fuller Marcus C. , Haas April N. , Bhat Bethany H. , Sallese Mary Rose , Smith S. D. , Yllades Valeria , Rodriguez Daira , Yoro Amara , Ganz J. B. 
Published: May 2023

Purpose:
This article provides a systematic review and analysis of group and single-case studies addressing augmentative and alternative communication (AAC) intervention with school-aged persons having autism spectrum disorder (ASD) and/or intellectual/developmental disabilities resulting in complex communication needs (CCNs). Specifically, we examined participant characteristics in group-design studies reporting AAC intervention outcomes and how these compared to those reported in single-case experimental designs (SCEDs). In addition, we compared the status of intervention features reported in group and SCED studies with respect to instructional strategies utilized.

Participants:
Participants included school-aged individuals with CCNs who also experienced ASD or ASD with an intellectual delay who utilized aided or unaided AAC.

Method:
A systematic review using descriptive statistics and effect sizes was implemented.

Results:
Findings revealed that participant features such as race, ethnicity, and home language continue to be underreported in both SCED and group-design studies. Participants in SCED investigations more frequently used multiple communication modes when compared to participants in group studies. The status of pivotal skills such as imitation was sparsely reported in both types of studies. With respect to instructional features, group-design studies were more apt to utilize clinical rather than educational or home settings when compared with SCED studies. In addition, SCED studies were more apt to utilize instructional methods that closely adhered to instructional features more typically characterized as being associated with behavioral approaches.

Conclusion:
The authors discuss future research needs, practice implications, and a more detailed specification of treatment intensity parameters for future research.
New design and simulation of the ion guide for neutron-induced fission products at the IGISOL facility
Authors: Gao Zhihao , Solders Andreas , Al-Adili Ali , Cannarozzo Simone , Lantz Mattias , Penttilä Heikki , Pomp Stephan ,   team
Published: May 2023

Measurements of independent fission yield distributions in neutron-induced fission at high neutron energies are important for our fundamental understanding of the fission process, and are also relevant for reactor physics applications. So far, measurements of independent fission yields in proton-induced fission have been performed at the IGISOL facility at the University of Jyväskylä, using the Penning trap as a high resolving-power mass-filter. In order to also facilitate measurements of neutron-induced fission, a dedicated ion guide and a proton-to-neutron converter was developed. However, the first measurement indicates that fewer fission products than expected reach the Penning trap. To explore potential reasons and possible improvements, a simulation model was also developed and benchmarked. The benchmark showed that the model is able to reproduce the performance of the ion guide remarkably well and that the main reason for the low yield of fission products is the low collection efficiency of the ion guide.
Based on the benchmark, a new ion guide is being designed. In the new design, the positions of the uranium targets and volume of the ion guide have been changed to increase the collection of fission products. This results in a five-fold increase of the yield. However, the collection efficiency of the new ion guide still needs to be improved in order to achieve intensities of the extracted fission products that are large enough to allow for reasonable measurement times.
Because the volume of the ion guide is increased significantly, the extraction time of the ions is expected to be longer than that from the previous ion guide. Therefore, an electric field guidance system that consists of a combination of a stationary electric field and an RF-carpet is considered to be deployed. The stationary field, produced from a set of DC-ring electrodes, accelerates the ions towards the RF-carpet at end plate of the ion guide. The RF-carpet consists of a time-dependent field, produced from a radio-frequent structure of concentric rings, with a DC-component that guides the ions towards the exit hole in the center of the end plate. In this paper we present the current status of the simulations and design of the new ion guide.
Effects of SGLT2 inhibitors on the intestinal bacterial flora in
Japanese patients with type 2 diabetes mellitus
Authors: Kusunoki Masataka , Hisano Fumiya , Matsuda Shin-ichi , Kusunoki Akiko , Wakazono Naomi , Tsutsumi Kazuhiko , Miyata Tetsuro 
Published: May 2023

AbstractSelective inhibitors of sodium glucose co-transporter-2 (SGLT2) suppress renal
glucose reabsorption and promote urinary glucose excretion, thereby lowering
blood glucose. SGLT2 inhibitors have been reported to reduce body weight.
However, the mechanism underlying the reduction in the body weight induced by
SGLT2 inhibitor treatment remains to be elucidated. In this study, we
investigated the effects of SGLT2 inhibitors on the intestinal bacterial flora.
A total of 36 Japanese patients with type 2 diabetes mellitus received a SGLT2
inhibitor (luseogliflozin or dapagliflozin) for 3 months, and the prevalences of
balance-regulating bacteria and balance-disturbing bacteria in the feces of the
patients before and after SGLT2 inhibitor treatment were determined. SGLT2
inhibitor treatment was associated with a significant increase of the overall
prevalence of the 12 types of balance-regulating bacteria. In addition,
significant increases in the prevalences of the short-chain fatty acid
(SCFAs)-producing bacteria among the balance-regulating bacteria were also
observed. Individual analyses of the balance-regulating bacteria revealed that
the SGLT2 inhibitor treatment was associated with a significant increase in the
prevalence of Ruminococci, which are balance-regulating bacteria
classified as SCFAs-producing bacteria. However, SGLT2 inhibitor had no effect
on the balance-disturbing bacteria. These results suggested that SGLT2 inhibitor
treatment was associated with an overall increase in the prevalence of
balance-regulating bacteria. Among the balance-regulating bacteria, the
prevalences of SCFAs-producing bacteria increased. SCFAs have been reported to
prevent obesity. The results of the present study suggest that SGLT2 inhibitors
might induce body weight reduction via their actions on the intestinal bacterial
flora.
Potential Involvement of Organic Anion Transporters in Drug Interactions with Shuganning Injection, a Traditional Chinese Patent Medicine
Authors: Bi Yajuan , Xing Yanchao , Gui Chunshan , Tian Yiqing , Zhang Mingzhe , Yao Yao , Hu Ge , Han Lifeng , He Feng , Zhang Youcai 
Published: May 2023

AbstractTraditional Chinese medicine injections have been widely used in China for the treatment of various diseases. Transporter-mediated drug-drug interactions are a major contributor to adverse
drug reactions. However, the research on transporter-mediated Traditional Chinese medicine injection-drug interactions is limited. Shuganning injection is a widely used Traditional Chinese
medicine injection for treating various liver diseases. In this study, we investigated the inhibitory effect of Shuganning injection and its four main ingredients (baicalin, geniposide,
chlorogenic acid, and oroxylin A) on 9 drug transporters. Shuganning injection strongly inhibited organic anion transporter 1 and organic anion transporter 3 with IC50 values
< 0.1% (v/v), and moderately inhibited organic anion transporter 2, organic anion transporting-polypeptide 1B1, and organic anion transporting-polypeptide 1B3 with IC50 values
< 1.0%. Baicalin, the most abundant bioactive ingredient in the Shuganning injection, was identified as both an inhibitor and substrate of organic anion transporter 1, organic anion
transporter 3, and organic anion transporting-polypeptide 1B3. Oroxylin A had the potential to act as both an inhibitor and substrate of organic anion transporting-polypeptide 1B1 and
organic anion transporting-polypeptide 1B3. In contrast, geniposide and chlorogenic acid had no significant inhibitory effect on drug transporters. Notably, Shuganning injection markedly
altered the pharmacokinetics of furosemide and atorvastatin in rats. Using Shuganning injection as an example, our findings support the implementation of transporter-mediated Traditional
Chinese medicine injection-drug interactions in the development of Traditional Chinese medicine injection standards.
Duchenne Muscular Dystrophy Fatigue Trajectories
Authors: Wei Yi Sally , Hnaini Mona , ElAloul Basmah , Zapata Eugenio , Campbell Craig 
Published: May 2023

Abstract
Introduction Children with Duchenne muscular dystrophy (DMD) are at risk of experiencing fatigue that negatively impacts their health-related quality of life (HRQoL). This study aimed to assess the association between fatigue and HRQoL, by examining fatigue trajectories over 48 weeks, and assessing factors associated with these fatigue trajectories.
Methods The study sample consisted of 173 DMD subjects enrolled in a 48-week-long phase 2 clinical trial (NCT00592553) for a novel therapeutic who were between the ages of 5 and 16 years.
Results The results of regression modeling show baseline fatigue and baseline HRQoL (R
2 = 0. 54 for child self-report and 0.51 for parent proxy report) and change in fatigue and HRQoL over 48 weeks (R
2 = 0.47 for child self-report and 0.36 for parent proxy report) were significantly associated with one another. Three unique fatigue trajectories using Latent Class Growth Models were identified for child and parent proxy reported fatigue. The risk of being in the high fatigue group as compared to the low fatigue group increased by 24% with each year increase in age and also with decreasing walking distance, as reported by children and parent proxy, respectively.
Conclusion This study identified fatigue trajectories and risk factors associated with greater fatigue, helping clinicians and researchers identify the profile of fatigue in DMD children.
Minimally Invasive Transnasal Approach to the Anteromedial Temporal Fossa and Lateral Sphenoid Using a Novel Landmark between Periorbita and Periosteum of the Pterygopalatine Fossa: A Cadaveric Study
Authors: Omura Kazuhiro , Kimple Adam J. , Senior Brent A. , Nomura Kazuhiro , Norris Meghan , Zeatoun Abdullah L. , Klatt-Cromwell Cristine , Ebert Charles S. , Otori Nobuyoshi , Thorp Brian D. 
Published: May 2023

AbstractThe anteromedial temporal region and the lateral wall of the sphenoid can be the site of an array of pathology including trigeminal schwannoma, encephalocele, cholesterol granuloma of the petrous apex, malignancy, infection, and sellar pathology extending to the lateral cavernous sinus. Approaches to this region are technically challenging and the existing approach requires sacrifice of all of the turbinates including the nasolacrimal duct, which can cause postoperative complications.We describe a novel anatomical landmark between the periorbita and the periosteum of the pterygopalatine fossa (which is located at the inferolateral periorbital periosteal line [ILPPL]). The posterior one-third of the incision line lies between the foramen rotundum and the superior orbital fissure, which is proximal to the maxillary strut.A 1.5-cm incision can divide the orbital and pterygoid contents and lead us to the posterior inferolateral orbital region, anteromedial temporal region, lateral wall of the sphenoid sinus, and lateral wall of the cavernous sinus.A combined multiangled approach to the ILPPL will enable us to preserve all of the turbinates and the septum, and the nasolacrimal duct, allowing for the preservation of the physiological function and pedicled flaps, such as the middle turbinate, inferior turbinate, and septal membrane flap.The ILPPL is a simple, effective, and novel landmark for the minimally invasive approach to the anteromedial temporal fossa.