bluuebunny/crossref_metadata_2025_split huggingface dataset:
TACE versus TACE + entecavir versus TACE + tenofovir in the treatment of HBV associated hepatocellular carcinoma
Authors: Lu Haohao , Zheng Chuansheng , Xiong Bin , Xia Xiangwen 
Published: March 2023

Abstract
Background
At present, there are a variety of antiviral drugs for HBV in clinical practice, but there is no standard scheme for transcatheter arterial chemoembolization(TACE) combined with antiviral drugs. The aim of this study was to investigate whether TACE must be combined with antiviral therapy in patients of HBV-related hepatocellular carcinoma(HCC). Meanwhile, the efficacy and safety of TACE combined with entecavir and TACE combined with tenofovir in the treatment of HBV-related HCC were compared.

Method
This study included 536 patients with HBV-related HCC who underwent TACE in Union Hospital from March 2017 to March 2020, and they met the criteria. They were divided into three groups: control group (N = 212): TACE alone; Entecavir group (N = 220): TACE combined with entecavir; and Tenofovir group (N = 228): TACE combined with tenofovir. We conducted a retrospective study to analyze the efficacy and safety of the three groups of patients.

Results
Objective response rate(ORR): 29.2% in control group, 54.1% in entecavir group, and 63.2% in tenofovir group (P < 0.05). Disease control rate(DCR): 63.7% in control group, 80.9% in entecavir group, and 88.1% in tenofovir group (P < 0.05). Median overall survival(mOS): control group, 12.2 months; entecavir group, 17.3 months; tenofovir group, 22.5 months (p < 0.05). Median progression-free survival (mPFS): control group, 9.3 months; entecavir group, 15.5 months; tenofovir group, 16.6 months (p < 0.05). At 6 months, there was an increase in creatinine(Cr) and a decrease in glomeruar filtration rate(GFR) in tenofovir group, which were statistically different from control and entecavir groups (p < 0.05).

Conclusion
TACE combined with entecavir and TACE combined with tenofovir had higher ORR and DCR, longer OS and PFS than TACE alone. The OS of TACE combined with tenofovir was higher than that of TACE combined with entecavir. TACE combined with tenofovir is a safe strategy, but we cannot completely ignore the impact of tenofovir on renal function.
Towards best practice in developing motor skills: a systematic review on spacing in VR simulator-based psychomotor training for surgical novices
Authors: Fahl Jan Torge , Duvivier Robbert , Reinke Laurens , Pierie Jean-Pierre E. N. , Schönrock-Adema Johanna 
Published: March 2023

Abstract
Objective
Repeated practice, or spacing, can improve various types of skill acquisition. Similarly, virtual reality (VR) simulators have demonstrated their effectiveness in fostering surgical skill acquisition and provide a promising, realistic environment for spaced training. To explore how spacing impacts VR simulator-based acquisition of surgical psychomotor skills, we performed a systematic literature review.

Methods
We systematically searched the databases PubMed, PsycINFO, Psychology and Behavioral Sciences Collection, ERIC and CINAHL for studies investigating the influence of spacing on the effectiveness of VR simulator training focused on psychomotor skill acquisition in healthcare professionals. We assessed the quality of all included studies using the Medical Education Research Study Quality Instrument (MERSQI) and the risk of bias using the Cochrane Collaboration’s risk of bias assessment tool. We extracted and aggregated qualitative data regarding spacing interval, psychomotor task performance and several other performance metrics.

Results
The searches yielded 1662 unique publications. After screening the titles and abstracts, 53 publications were retained for full text screening and 7 met the inclusion criteria. Spaced training resulted in better performance scores and faster skill acquisition when compared to control groups with a single day (massed) training session. Spacing across consecutive days seemed more effective than shorter or longer spacing intervals. However, the included studies were too heterogeneous in terms of spacing interval, obtained performance metrics and psychomotor skills analysed to allow for a meta-analysis to substantiate our outcomes.

Conclusion
Spacing in VR simulator-based surgical training improved skill acquisition when compared to massed training. The overall number and quality of available studies were only moderate, limiting the validity and generalizability of our findings.
Intervention-related, contextual and personal factors affecting the implementation of an evidence-based digital system for prevention and treatment of malnutrition in elderly institutionalized patients: a qualitative study
Authors: Varsi Cecilie , Andersen Lene Frost , Koksvik Gunhild Tellebon , Severinsen Frida , Paulsen Mari Mohn 
Published: March 2023

Abstract
Background
Malnutrition in elderly institutionalized patients is a significant challenge associated with adverse health outcomes. The ‘MyFood’ decision support system was designed to prevent and treat malnutrition and has previously been studied in a hospital setting. The aim of this study was to explore the experiences of nursing staff regarding the implementation of MyFood in settings treating elderly patients.

Methods
The study was conducted in two settings treating elderly patients in Norway. Nursing staff received training in how to follow-up patients with MyFood. Qualitative interviews were conducted with 12 nursing staff. The Consolidated Framework for Implementation Research (CFIR) was used to guide the data collection and the thematic data analysis.

Results
The implementation of a digital decision support system to prevent and treat malnutrition into settings treating elderly patients was found to be affected by intervention-related, contextual, and personal factors. Although nursing staff experienced several advantages, the leadership engagement was low and hampered the implementation.

Conclusion
Nursing staff experienced several advantages with implementing a digital decision support system for the prevention and treatment of malnutrition in institutionalized elderly patients, including quality improvements and time savings. The results indicate that the leadership engagement was weak and that some nursing staff experienced low self-efficacy in digital competence. Future improvements include increasing the level of training, using MyFood throughout the patient course and involving the patient’s next-of-kin.

Trial registration
The study was acknowledged by The Norwegian Centre for Research Data (NSD), ref. number 135175.
Multimolecular characteristics and role of BRCA1 interacting protein C-terminal helicase 1 (BRIP1) in human tumors: a pan-cancer analysis
Authors: Wang Ruohuang , Zhang Jisheng , Cui Xin , Wang Shun , Chen Ting , Niu Yanfang , Du Xiaoyun , Kong Jingwen , Wang Lin , Jiang Yan 
Published: March 2023

Abstract
Background
The aberrant expression of BRIP1 was associated with several cancers; however, the panoramic picture of BRIP1 in human tumors remains unclear. This study aims to explore the pan-cancerous picture of the expression of BRIP1 across 33 human cancers.

Methods
Based on the data from TCGA and GTEx, a series of bioinformatic analyses were applied to systematically explore the genetic landscape and biologic function of BRIP1 in 33 human tumors.

Results
We observed prognosis-related differential BRIP1 expressions between various carcinomas and the corresponding normal tissues. “Basal transcription factors,” “homologous recombination,” “nucleotide excision repair,” and DNA metabolism pathways may play a role in the functional mechanisms of BRIP1. Patients with uterine corpus endometrial carcinoma presented with the highest alteration frequency of BRIP1 (nearly 10%). Single-nucleotide and copy number variations of BRIP1 were noticed in multiple cancers, and the expression of BRIP1 is significantly regulated by copy number variation in breast invasive carcinoma and lung squamous cell carcinoma. BRIP1 expression is negatively correlated with the DNA methylation levels in many tumors and is associated with the activation of apoptosis, cell cycle, DNA damage response, and inhibition of hormone ER and RNS/MARK signaling pathways. Moreover, a positive correlation was observed between BRIP1 expression and the immune infiltration levels of cancer-associated fibroblasts and CD8+ T cells in lung adenocarcinoma.

Conclusion
Our pan-cancer analysis of BRIP1 provides a valuable resource for understanding the multimolecular characteristics and biological function of BRIP1 across human cancers.
An EMT-based gene signature enhances the clinical understanding and prognostic prediction of patients with ovarian cancers
Authors: Li Qi-jia , Wu Zi-liang , Wang Juan , Jiang Jing , Lin Bing 
Published: March 2023

Abstract
Background
Ovarian cancer (OC) is one of the most common gynecological cancers with malignant metastasis and poor prognosis. Current evidence substantiates that epithelial-mesenchymal transition (EMT) is a critical mechanism that drives OC progression. In this study, we aspire to identify pivotal EMT-related genes (EMTG) in OC development, and establish an EMT gene-based model for prognosis prediction.

Methods
We constructed the risk score model by screening EMT genes via univariate/LASSO/step multivariate Cox regressions in the OC cohort from TCGA database. The efficacy of the EMTG model was tested in external GEO cohort, and quantified by the nomogram. Moreover, the immune infiltration and chemotherapy sensitivity were analyzed in different risk score groups.

Results
We established a 11-EMTGs risk score model to predict the prognosis of OC patients. Based on the model, OC patients were split into high- and low- risk score groups, and the high-risk score group had an inevitably poor survival. The predictive power of the model was verified by external OC cohort. The nomogram showed that the model was an independent factor for prognosis prediction. Moreover, immune infiltration analysis revealed the immunosuppressive microenvironment in the high-risk score group. Finally, the EMTG model can be used to predict the sensitivity to chemotherapy drugs.

Conclusions
This study demonstrated that EMTG model was a powerful tool for prognostic prediction of OC patients. Our work not only provide a novel insight into the etiology of OC tumorigenesis, but also can be used in the clinical decisions on OC treatment.
Angiotensin 1–7 in an experimental septic shock model
Authors: Garcia Bruno , Su Fuhong , Manicone Francesca , Dewachter Laurence , Favory Raphaël , Khaldi Amina , Moiroux-Sahroui Alexander , Moreau Anthony , Herpain Antoine , Vincent Jean-Louis , Creteur Jacques , Taccone Fabio Silvio , Annoni Filippo 
Published: March 2023

Abstract
Background
Alterations in the renin–angiotensin system have been implicated in the pathophysiology of septic shock. In particular, angiotensin 1–7 (Ang-(1–7)), an anti-inflammatory heptapeptide, has been hypothesized to have beneficial effects. The aim of the present study was to test the effects of Ang-(1–7) infusion on the development and severity of septic shock.

Methods
This randomized, open-label, controlled study was performed in 14 anesthetized and mechanically ventilated sheep. Immediately after sepsis induction by bacterial peritonitis, animals received either Ang-(1–7) (n = 7) or placebo (n = 7) intravenously. Fluid resuscitation, antimicrobial therapy, and peritoneal lavage were initiated 4 h after sepsis induction. Norepinephrine administration was titrated to maintain mean arterial pressure (MAP) between 65 and 75 mmHg.

Results
There were no differences in baseline characteristics between groups. Septic shock was prevented in 6 of the 7 animals in the Ang-(1–7) group at the end of the 24-h period. Fluid balance and MAP were similar in the two groups; however, MAP was achieved with a mean norepinephrine dose of 0.4 μg/kg/min in the Ang-(1–7) group compared to 4.3 μg/kg/min in the control group. Heart rate and cardiac output index were lower in the Ang (1–7) than in the control group, as were plasma interleukin-6 levels, and creatinine levels. Platelet count and PaO2/FiO2 ratio were higher in the Ang-(1–7) group. Mean arterial lactate at the end of the experiment was 1.6 mmol/L in the Ang-(1–7) group compared to 7.4 mmol/L in the control group.

Conclusions
In this experimental septic shock model, early Ang-(1–7) infusion prevented the development of septic shock, reduced norepinephrine requirements, limited interleukine-6 increase and prevented renal dysfunction.
Subsurface structure identification at the blind prediction site of ESG6 based on the earthquake-to-microtremor ratio method and diffuse field concept for earthquakes
Authors: Nagashima Fumiaki , Kawase Hiroshi , Nakano Kenichi , Ito Eri 
Published: March 2023

AbstractWe participated in the blind prediction exercise organized by the committee of the blind prediction experiment during the 6th International Symposium on Effects of Surface Geology on Seismic Motion (CBP-ESG6). In response to the committee's request, we identified the ground velocity structure from microtremors observed at a target site as the first step of the exercise. First, we calculated the horizontal-to-vertical spectral ratio of microtremors (MHVR) at the target site from the distributed microtremor data collected in the vicinity of the target site in Kumamoto Prefecture. Then, we converted the MHVR into a pseudo horizontal-to-vertical spectral ratio of earthquake (pEHVR) using the previously proposed and validated earthquake-to-microtremor ratio (EMR) method, where an empirically obtained EMR is used to convert MHVR into pEHVR. Next, we inverted the S-wave and P-wave velocity structures based on the pEHVR and the diffuse field concept for earthquakes. The theoretical EHVR calculated from the identified velocity structure reproduced the pEHVR quite well in the frequency range of 0.1–22 Hz. After the collection of the blind prediction results by all the participants, the CBP-ESG6 released the observed earthquake records, a preferred model based on the P–S logging data from the in-situ borehole measurement combined with the generic deeper structure, and the average of all the predicted structures by the participants. Notably, our inverted structure was found to be close to the preferred model and the averaged one of all the blind prediction participants, despite some minor differences in the horizontal site amplification factor around the maximum peak frequency at 0.8–1 Hz.Graphical Abstract
Narratives and Empirical Strategies in Zvi Griliches's Early Research
Authors: Biddle Jeff E. 
Published: March 2023

Abstract
Zvi Griliches was one of the leading econometricians of his generation. His early work involved empirical analyses of the sources of productivity growth in twentieth-century US agriculture, including his dissertation on the diffusion of hybrid corn and his analysis of the long-run growth in fertilizer use by US farmers. In this research Griliches developed theoretical explanations of these phenomena in the form of narratives of rational, profit-seeking people responding to changing circumstances and novel information, and he used these narratives to inform his decisions about what statistical techniques to employ and how to implement them. Narratives served the same purposes for Griliches that mathematical models were coming to serve in the work of his contemporaries, but they made more sense for Griliches, given his belief that he was analyzing transitions between economic equilibria, a process for which economists had not developed useful mathematical models.
Graphic Disciplines and Informatization of Engineering Education
Authors: Kozlova I. , Slavin R. , Slavin Boris 
Published: March 2023

The development of information technology has given a significant impetus and progress both for various industries and life, as well as for education. The national program "Digital Economy of the Russian Federation" provides for ensuring the introduction of digital technologies in the economy and social sphere, and is associated with the National Project "Education (2019-2024)", which includes the Federal Project "Digital Educational Environment" based on the introduction of the target model of modern digital technologies into educational programs. Innovative methods and forms of training create a strategy for the professional training of specialists, and computer visibility of the forms of the part gives an idea of the assembly technology, allows you to perform competent drawings. The purpose of the study is to analyze the methods of solving the problems of descriptive geometry and engineering graphics together with the use of methods of surface formation by geometric methods, as well as on the basis of basic CAD operations COMPASS-3D.
In modern high school, in most cases, drawing is not studied, or only the most general concepts and definitions are studied. The existing course of school computer science deals only with general issues and practically does not give skills in drawing and modeling. As a result, applicants for the most part come to a technical university unprepared for the normal perception of geometric and graphic disciplines. In this regard, two priority tasks of further informatization of engineering education at the technical university have been formulated. On the one hand, this is the improvement of the methodology for teaching geometro-graphic disciplines, including in distance learning. On the other hand, it is the involvement of schoolchildren in various Olympiads and competitions held on the basis of technical universities to develop the initial skills of drawing and modeling simple objects.
Changes to The Competences Requirements of Project Managers Under The Influence Of Sustainability In Russia
Authors: Kalganova Ariana , Ryabtseva Elena , Rakhmankulov Daniil , Khalimon Ekaterina 
Published: March 2023

IProject management and sustainable development are ones of the most important concepts that have gained great popularity in the scientific community in recent years. The need to integrate sustainability into project management is increasing every year changing the requirements for project managers` competencies.
Despite of the growing scientific interest in this topic, there is a small number of research papers that consider the impact of the concept of sustainability on the competences of a project manager. Thus, the purpose of this study is to identify the most important knowledge, skills and abilities and personal qualities needed by project managers for successful sustainable project management.
The research is based on the analysis of the sources of scientific literature, international, and national standards in the field of project management.
The results showed that over the past 5 years the project manager profession has undergone significant changes, and in order to achieve sustainability project managers need to develop new professional competencies based on knowledge, skills and abilities, and personal qualities.
GELENEKSEL TÜRK GELİNİNİN BÜYÜSEL ERGİNLENME YOLCULUĞU
Authors: DEMİR Turan 
Published: March 2023

Toplumsal ve bireysel yaşamda kendine yer edinmeye çalışan insan, dünyadaki varlığı boyunca çeşitli evrelerden geçmektedir. Bireyin dünyaya hem psikolojik hem de sosyolojik bir uyum sağlaması için gerçekleşen bu evreler doğumla başlayıp evlilikle devam eder ve de ölümle sonlanır. Söz konusu bu evreler genel bağlamda geçiş dönemleri/ritleri olarak adlandırılır. Birey, bu geçiş dönemlerine ilkel zamanlardan beri büyüsel ve mitolojik özellikler taşıyan törenlerle/ritüellerle hazırlanır. Geçiş dönemleri krizlerle dolu bir süreçtir ve birey, biyolojik yeterliliğinin yanında psikolojik olarak da erginlenme süreçlerini atlatarak toplum içindeki yeni statüsüne bir kabul töreni ile kavuşur.
Evlilik, geçiş dönemleri içerisinde doğumu ve ölümü hazırlayan önemli bir süreçtir. Soyun devamı kültürel kodlarla örülmüş evlilik ile sağlanırken yaşayan her varlığın ölümü gerçekleşeceğinden bu süreç geçiş dönemlerini bütünleştiren bir işleve sahiptir. Evlilik bağlamında gerçekleşen geçiş döneminde kadının erginlenme süreci büyüsel pek çok anlam ve ritüel içermektedir. Evlilik, geleneksel Türk gelininin genç kızlığa veda etme törenidir. Evlilik süreçlerinde krizin merkezi gelin adayı kızdır ve gelin olacak kız, doğup büyüdüğü yerden ayrılıp doğurduğu çocuğu büyüteceği yeni bir alana öteki bireye dönüşerek geçer. Bu kriz döneminin rahat atlatılması için de birçok büyüsel ritüel sergilenir. Ortaya konan bu çalışmada da geleneksel Türk gelinin büyüsel erginlenme yolculuğu ele alınmıştır.
NEONATAL HIP ASSESSMENT: PREDICTABLE FAILURE
Authors: Burt J. , AlKandari N. , Campbell D.M. , Maclean J.G.B. 
Published: March 2023

The UK falls behind other European countries in the early detection of Developmental Dysplasia of the hip (DDH) and there remains controversy surrounding screening strategies for early detection. Clinical detection of DDH is challenging and recognised to be dependent on examiner experience. No studies exist assessing the number of personnel currently involved in such assessments.Our objective was to study the current screening procedure by studying a cohort of new-born babies in one teaching hospital and assess the number of health professionals involved in neonatal hip assessment and the number of examinations undertaken during one period by each individual.This was a retrospective observational study assessing all babies born consecutively over a 14-week period in 2020. Record of each initial baby check was obtained from Maternity or Neonatal Badger. Follow-up data on ultrasound or orthopaedic outpatient referrals were obtained from clinical records.1037 babies were examined by 65 individual examiners representing 9 different healthcare professional groups. The range of examinations conducted per examiner was 1- 97 with a mean of 15.9 examinations per person. 49% individuals examined 5 or less babies across the 14 weeks, with 18% only performing 1 examination. Of the 5 babies (0.48%) treated for DDH, one was picked up on neonatal assessment.In a system where so many examiners are involved in neonatal hip assessment the experience is limited for most examiners. It is unsurprising that high current rates of late presentation of DDH are observed locally, which are in accordance with published national experience.
RE-REVISION KNEE ARTHROPLASTY: THE EFFECT OF TIME FROM PRIMARY TO FIRST REVISION. A STUDY OF 4,723 PATIENTS FROM THE SCOTTISH ARTHROPLASTY PROJECT
Authors: Jabbal A. , Burt J. , Moran M. , Clarke J. , Jenkins P.J. , Walmsley P. 
Published: March 2023

Revision Total Knee Arthroplasty (rTKA) is predicted to increase by more than 600% between 2005 and 2030. The survivorship of primary TKA has been extensively investigated, however more granular information on the risks of rTKA is needed. The aim of the study was to investigate the incidence of re-revision TKA, with explanatory variables of time from primary to revision, and indication (aseptic vs septic). Secondary aim was to investigate mortality.This is an analysis of the Scottish Arthroplasty Project data set, a national audit prospectively recording data on all joint replacements performed in Scotland. The period from 2000 to 2019 was studied.4723 patients underwent revision TKA. The relationship between time from primary to revision TKA and 2nd revision was significant (p<0.001), with increasing time lowering probability of re-revision (OR 0.99 95% CI 0.987 to 0.993). There was no significant association in time to first revision on time from 1st revision to re-revision (p>0.05). Overall mortality for all patients was 32% at 10 years (95% CI 31-34), Time from primary TKA to revision TKA had a significant effect on mortality: p=0.004 OR 1.03 (1.01-1.05). Septic revisions had a reduced mortality compared to aseptic, OR 0.95 (0.71-1.25) however this was not significant (p=0.69).This is the first study to demonstrate time from primary TKA to revision TKA having a significant effect on probability of re-revision TKA. Furthermore the study suggests mortality is increased with increasing time from primary procedure to revision, however decreased if the indication is septic rather than aseptic.