bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN METODE FUZZY TSUKAMOTO PADA PERTIMBANGAN PENGANGKATAN KARYAWAN TETAP BERBASIS WEB
Authors: Nurwanda Abdi , Syah Arridha Zikra , Putra Guntur Maha 
Published: April 2023

Abstract:Being a permanent employee are people who are still employees, that is a clear and guaranteed future, which gets more bonuses than contract employees. One of the national trading companies in Indonesia, namely PT Pinus Merah Abadi, also recruits employees both at the head office and at each branch of the company, but in the process decisions made for employees cannot be made by employees. branch of the company, even in the number of many who are disadvantaged because the manual is still carried out by the manager, which is then filtered by the head office. To use these things, in this study a system that supports decisions in branch offices will be made using the fuzzy tsukamoto method which is expected to work from employees. And after the support system takes this decision, employees have made successful decisions, because employees can immediately see the calculation process through the application that has been made. Keywords: fuzzy tsukamoto; permanent employee; decision support system Abstrak:Menjadi seorang karyawan tetap di sebuah perusahaan adalah keinginna banyak orang yang masih menjadi seorang karyawan kontrak, selain masa depan yang jelas dan terjamin, seorang karyawan tetap mendapatkan bonus yang lebih banyak dibandingkan dengan karyawan kontrak. Salah satu perusahaan dagang nasional di Indonesia yaitu PT Pinus Merah Abadi juga melakukan perekrutan untuk karyawan tetap setiap tahunnya baik di kantor pusat maupun di setiap cabang perusahaan, namun dalam prosesnya terkadang keputusan yang dibuat mengenai pengangkatan karyawan tetap oleh perusahaan tidak memuaskan para karyawan yang ada di cabang perusahaan, bahkan terkadang para karyawan merasa dirugikan karena perhitungan nya masih dilakukan manual oleh manajer, yang kemudian diproses oleh kantor pusat. Untuk menangani hal tersebut, dalam penelitian ini akan dibuat sebuah sistem pendukung keputusan di kantor cabang perusahaan khususnya kantor cabang kisaran menggunakan metode fuzzy tsukamoto yang diharapkan bisa menangani keluhan dari para karyawan. Dan setelah sistem pendukung keputusan ini digunakan, para karyawan cabang sudah bisa menerima keputusan yang telah dibuat manajer, karena karyawan bisa langsung melihat proses perhitungannya melalui apikasi yang sudah dibuat. Kata kunci: fuzzy tsukamoto; karyawan tetap; sistem pengambilan keputusan
Estudo comparativo entre a autopercepção das características cutâneas e o formulário Baumann
Authors: Souza Camilla Radimack Santos de , Fontes Rafael Barros , Godoy Charles Antônio Pires de 
Published: April 2023

O presente estudo teve por objetivo observar e entender o autoconhecimento da população selecionada no que tange os tipos de pele apresentadas por moradores do estado de Sergipe, dentro da faixa etária de 20 a 60 anos de idade, de ambos os sexos e diversas etnias. Para isto, aplicou-se aos voluntários o questionário de Baumann, desenvolvido pela dermatologista Leslie Baumann nos EUA e composto de 64 perguntas que classificam a pele em relação à hidratação, à sensibilidade, à pigmentação e à tendência a rugas. Os resultados obtidos, inicialmente, mostram que há predominância, entre os avaliados, de pessoas com pele com sensibilidade aumentada, grande quantidade de sebo, com baixo nível de pigmentação e com tendência a rugas. Considerando a alta miscigenação no estado de Sergipe, em decorrência do período colonial, e das características da maior parte da população avaliada, o presente estudo evidencia a importância dos cuidados gerais para esta população.
2,5(6)-DİSÜBSTİTÜEBENZİMİDAZOL TÜREVİ LİGANDLARI TAŞIYAN PLATİN KOMPLEKSLERİNİN SENTEZİ VE ANTİKANSER AKTİVİTELERİNİN ARAŞTIRILMASI
Authors: ALJENDY Yasmin , ORUÇ DEMİRBAĞ Hatice , BAYRAM Gül , UTKU Semra 
Published: April 2023

Amaç: Sisplatin, klinikte kanser hastalarının tedavisinde başarılı bir şekilde kullanılmasına rağmen hastalarda rezistans gelişimi ve ciddi toksik yan etkiler görülmektedir. Bu dezavantajların önüne geçmek için bu çalışmada 2,5(6)-disübstitüebenzimidazol türevi taşıyıcı ligandlar kullanarak platin(II) komplekslerinin sentezlenmesi ve sitotoksik etkilerinin test edilmesi amaçlanmıştır.
Gereç ve Yöntem: L1-L6 taşıyıcı ligandları Philips yöntemine göre elde edilmiştir. K1-K4 kompleksleri, K2PtCl4 ve uygun ligandın ısıtılıp karıştırılması ile sentezlenmiştir. Sentez edilen L1-L6 ve K1-K4’ün kimyasal yapıları elementel analiz, İnfrared ve 1H Nükleer Manyetik Rezonans ile aydınlatılmıştır. L1-L6 taşıyıcı ligandları ve K1-K4 komplesklerinin, MTT yöntemi ile MCF-7 ve DU-145 hücre hatlarına karşı in vitro sitotoksik etkileri test edilmiştir.
Sonuç ve Tartışma IC50 değerlerine göre 2 numaralı konumunda –CH3 sübstitüenti taşıyan ligandlar, nonsübstitüe ligandlara göre test edilen hücre hatlarında daha etkili bulunmuştur. Ayrıca 5(6) numaralı konumunda flor sübstitüe L5 ve L6 en etkili benzimidazol türevi olarak test edilmiştir. Test edilen kompleksler içerisinde K3, MCF-7 hücre hattına karşı 32.75 µM IC50 değeri ile DU-145 hücre hattında ise 18.842 µM IC50 değeri ile en etkili kompleks olarak bulunmuştur.
Drivers for ecosystem respiration during the drawdown period in Dongting Lake, China
Authors: Zhou Yan , Jing Lei , Wang Shaoquan , Jia Yifei , Wang Yushu , Lei Guangchun 
Published: April 2023

Global lakes play an active role in releasing carbon into the atmosphere. However, previous research was less focused on shallow tropical and sub-tropical lakes, especially ecosystem respiration during the drawdown period. This study was designed to determine the environmental factors that determine ecosystem respiration during the drawdown period in a typical shallow sub-tropical lake, Dongting Lake in China. Ecosystem respiration from the exposed mudflat and a newly colonized meadow were investigated using a Li-8100 soil CO2 flux system in situ. The soil water content soil organic carbon (SOC), dissolved organic carbon (DOC), total nitrogen and soil C/N ratio were measured at 0–30 cm soil depth layers. No difference was found among different soil depth layers for soil properties, while the dissolved organic carbon value varied significantly among different levels of the cumulative days of the mudflat exposed to the air (CDE). Carex colonizing significantly increased soil organic carbon and DOC at the surface soil layer. Exposure to the air and Carex colonizing together strengthened the intensity of carbon dioxide (CO2) emission in the mudflat, achieving 0.716 ± 0.114 μmol m-2s-1 and 2.240 ± 0.375 μmol m-2s-1, respectively. Exposure to the air led mudflat to exceed other landscapes or different vegetation types in Dongting Lake, becoming the most active area releasing CO2 into the atmosphere, with the respiration flux reaching a peak period at around 60 days after exposure, which was enormously reinforced by Carex colonizing. Reducing the area and duration of mudflat exposure to the air during the drawdown period might be useful in reducing CO2 emissions to the atmosphere in shallow sub-tropical lakes.
The human P2X7 receptor alters microglial morphology and cytokine secretion following immunomodulation
Authors: von Mücke-Heim Iven-Alex , Martin Jana , Uhr Manfred , Ries Clemens , Deussing Jan M. 
Published: April 2023

Introduction: In recent years, purinergic signaling via the P2X7 receptor (P2X7R) on microglia has repeatedly been implicated in depression genesis. However, it remains unclear which role the human P2X7R (hP2X7R) plays in regulating both microglia morphology and cytokine secretion upon different environmental and immune stimuli, respectively.Methods: For this purpose, we used primary microglial cultures derived from a humanized microglia-specific conditional P2X7R knockout mouse line to emulate different gene-environment interactions between microglial hP2X7R and molecular proxies of psychosocial and pathogen-derived immune stimuli. Microglial cultures were subjected to treatments with the agonists 2′(3′)-O-(4-benzoylbenzoyl)-ATP (BzATP) and lipopolysaccharides (LPS) combined with specific P2X7R antagonists (JNJ-47965567, A-804598).Results: Morphotyping revealed overall high baseline activation due to the in vitro conditions. Both BzATP and LPS + BzATP treatment increased round/ameboid microglia and decreased polarized and ramified morphotypes. This effect was stronger in hP2X7R-proficient (CTRL) compared to knockout (KO) microglia. Aptly, we found antagonism with JNJ-4796556 and A-804598 to reduce round/ameboid microglia and increase complex morphologies only in CTRL but not KO microglia. Single cell shape descriptor analysis confirmed the morphotyping results. Compared to KO microglia, hP2X7R-targeted stimulation in CTRLs led to a more pronounced increase in microglial roundness and circularity along with an overall higher decrease in aspect ratio and shape complexity. JNJ-4796556 and A-804598, on the other hand, led to opposite dynamics. In KO microglia, similar trends were observed, yet the magnitude of responses was much smaller. Parallel assessment of 10 cytokines demonstrated the proinflammatory properties of hP2X7R. Following LPS + BzATP stimulation, IL-1β, IL-6, and TNFα levels were found to be higher and IL-4 levels lower in CTRL than in KO cultures. Vice versa, hP2X7R antagonists reduced proinflammatory cytokine levels and increased IL-4 secretion.Discussion: Taken together, our results help disentangle the complex function of microglial hP2X7R downstream of various immune stimuli. In addition, this is the first study in a humanized, microglia-specific in vitro model identifying a so far unknown potential link between microglial hP2X7R function and IL-27 levels.
Perception and kairomonal response of the coccinellid predator (Harmonia axyridis) to the fall armyworm (Spodoptera frugiperda) sex pheromone
Authors: Zhan Yidi , Wang Jiaojiao , Kong Xiaona , Liu Yong 
Published: April 2023

Pheromone cues released from hosts or prey are of crucial importance to natural enemies for prey and habitat location. The use of herbivorous insect sex pheromones has long been considered as a potential pest control alternative that is non-toxic and harmless to beneficials. We hypothesized that Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), a major predatory coccinellid beetle of the devastating migratory pest Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae), could perceive and use the sex pheromone of S. frugiperda to locate its habitat. Here we tested the electrophysiological and behavioral responses of H. axyridis to the two components Z7-12:Ac and Z9-14:Ac of S. frugiperda sex pheromone by using electroantennography (EAG) and Y-tube bioassay. The 3D modeling of H. axyridis odorant-binding proteins (HaxyOBPs) and molecular docking were also performed. The results showed that both female and male H. axyridis exhibited significantly higher electrophysiological and behavioral responses to Z9-14:Ac at the concentrations of 0.001, 0.01, and 0.1 μg/μL, while no significant electrophysiological and behavioral responses of H. axyridis were observed to Z7-12:Ac. The blend of Z7-12:Ac and Z9-14:Ac at the ratio of 1:100 had a significant attraction to both male and female H. axyridis at the concentrations of 0.01 and 0.1 μg/μL based on electrophysiological and behavioral assays, but no significant behavioral responses were observed at the ratios of 1:9. According to the 3D modeling of HaxyOBPs and molecular docking, HaxyOBP12 has a good affinity with Z9-14:Ac. Z9-14:Ac is bound to the HaxyOBP12 by hydrogen bonding and hydrophobic interactions. However, there were no credible docking results between HaxyOBPs and Z7-12:Ac. Our findings revealed that H. axyridis can perceive Z9-14:Ac and could use it as a chemical cue to locate prey habitat. We speculated that Z7-12:Ac, which showed some antagonistic effect toward the response of H. axyridis to Z9-14:Ac, could improve the adaptability of S. frugiperda in the presence of predators. This study provides new insights into the application of pheromones to manipulate natural enemy behavior for pest control.
Phytochemicals in Gastrointestinal Nematode Control: Pharmacokinetic–Pharmacodynamic Evaluation of the Ivermectin plus Carvone Combination
Authors: Miró María Victoria , Costa-Júnior Livio Martins , Lloberas Mercedes , Cardozo Patricia , Lanusse Carlos , Virkel Guillermo , Lifschitz Adrián 
Published: April 2023

A wide variety of plant-derived phytochemicals with anthelmintic effects have been described. Most of them have shown activity against parasites in vitro but have not been extensively explored in vivo. The aim of the current work was to study the pharmacokinetic–pharmacodynamic relationship of the combined administration of carvone (R-CNE) and ivermectin (IVM) to lambs. Three trials were conducted to evaluate the pharmacological interaction between R-CNE and IVM in lambs infected with resistant nematodes. Drug concentrations were measured in plasma, target tissues, and H. contortus by HPLC with fluorescent (IVM) and ultraviolet (R-CNE) detection. The effect of both compounds on parasites was estimated by the fecal egg count reduction. Coadministration with R-CNE significantly increased the plasma bioavailability of IVM. R-CNE showed a moderate anthelmintic effect, which was greater on the susceptible isolate of H. contortus. After the combination of R-CNE and IVM as an oral emulsion, both compounds were quantified in H. contortus recovered from infected lambs. However, R-CNE concentrations were much lower than those reported to achieve anthelmintic effects in the in vitro assays. Optimization of the pharmaceutical formulation, dose rate, and administration schedule is needed to take advantage of the intrinsic anthelmintic activity of phytochemicals.
Mitogen-Activated Protein Kinases SvPmk1 and SvMps1 Are Critical for Abiotic Stress Resistance, Development and Pathogenesis of Sclerotiophoma versabilis
Authors: Abah Felix , Kuang Yunbo , Biregeya Jules , Abubakar Yakubu Saddeeq , Ye Zuyun , Wang Zonghua 
Published: April 2023

Mitogen-activated protein kinase (MAPK) signaling pathways are evolutionarily conserved in eukaryotes and modulate responses to both internal and external stimuli. Pmk1 and Mps MAPK pathways regulate stress tolerance, vegetative growth and cell wall integrity in Saccharomyces cerevisiae and Pyricularia oryzae. Here, we deployed genetic and cell biology strategies to investigate the roles of the orthologs of Pmk1 and Mps1 in Sclerotiophoma versabilis (herein referred to as SvPmk1 and SvMps1, respectively). Our results showed that SvPmk1 and SvMps1 are involved in hyphal development, asexual reproduction and pathogenesis in S. versabilis. We found that ∆Svpmk1 and ∆Svmps1 mutants have significantly reduced vegetative growths on PDA supplemented with osmotic stress-inducing agents, compared to the wild type, with ∆Svpmps1 being hypersensitive to hydrogen peroxide. The two mutants failed to produce pycnidia and have reduced pathogenicity on Pseudostellaria heterophylla. Unlike SvPmk1, SvMps1 was found to be indispensable for the fungal cell wall integrity. Confocal microscopic analyses revealed that SvPmk1 and SvMps1 are ubiquitously expressed in the cytosol and nucleus. Taken together, we demonstrate here that SvPmk1 and SvMps1 play critical roles in the stress resistance, development and pathogenesis of S. versabilis.
COGNITIVE MANAGEMENT OF THE INNOVATIVE POTENTIAL OF THE FOREST COMPLEX
Authors: Tret'yakova L. , Lavrikova N. , Azarova Natalia 
Published: April 2023

In this article, the subject of study is the process of cognitive management and modeling of the innovative potential of the forest complex. The purpose of the study is to create a combined approach of cognitive management of information and innovation flows in the forest complex. The theoretical basis of cognitive management of the innovative potential of the forest complex was studied.
The system of sustainable modern management and planning in the forest complex is an urgent task. The multicomponent criteria taken into account in the framework of managerial decision-making includes consideration of various criteria, such as the estimated income from the sale of wood, soil erosion, the likelihood of natural forest fires.
In a situation of global economic and environmental challenges, awareness of the need for sustainable economic growth and in the transition from a resource economy to an innovative one, the concept of cognitive management helps to select priority areas of innovative development. Also in this article, in order to realize the innovative potential, a cognitive model of innovation management is presented; the areas and specifics of the implementation of this model at various stages of management are shown. The creation of a cognitive management system is conditioned by the values of many variables of the definitions under study, such as income, demand for wood, biodiversity of forest lands, risks, intellectual capital, intellectual potential, digitalization component.
Implementation of Decisions of the VIII Congress of Clinical Laboratory Services Doctors: Contribution to Their Implementation by the Department of Clinical Laboratory Diagnostics of the Belarusian Medical Academy of Postgraduate Education
Authors: Камышников В.С. 
Published: April 2023

Выход в свет настоящей статьи вызван намерением создать своеобразное «связующее звено» между кругом вопросов, представленных к обсуждению на состоявшемся последнем, VIII Съезде врачей клинико-лабораторной службы (2016), делегатами которого была утверждена Концепция совершенствования организации деятельности и подготовки кадров службы клинической лабораторной диагностики, и постановкой тех новых задач, которые будут выдвинуты к обсуждению участниками очередного съезда (конгресса) специалистов лабораторной медицины. Уделено внимание перечню и итогам реализации приоритетных направлений деятельности клинической лабораторной службы, к числу которых были отнесены: 1. Совершенствование кадровой политики в службе клинической лабораторной диагностики. 2. Совершенствование технологий и внедрение системы контроля качества лабораторных исследований во всех регионах республики. 3. Оптимизация централизованного и планового выполнения лабораторно-диагностических исследований. 4. Совершенствование организационно-методической и информативной деятельности. 5. Организация лабораторного обеспечения дежурной и неотложной служб. 6. Мероприятия по совершенствованию существующей системы закупок изделий медицинского назначения. 7. Формирование научно-технической политики в области клинико-лабораторной службы. Подведены итоги реализации Концепции развития национальной клинической лабораторной службы.
The publication of this article was motivated by the intention to create some kind of "link" between the range of issues presented for discussion at the last, VIII Congress of Clinical Laboratory Diagnostics Doctors (2016), whose delegates approved the Concept for improving the Organization of Activities and Training of Staff of Clinical Laboratory Diagnostics Services, and the formulation of those new tasks that will be put forward for discussion by the next Forum (Congress) of laboratory medicine specialists. Attention was paid to the list and results of the implementation of priority areas of clinical laboratory service activities, which included the following: 1. Improvement of personnel policy in clinical laboratory diagnostics service. 2. Improvement of technologies and implementation of laboratory testings quality control system in all regions of the republic. 3. Optimization of centralized and scheduled laboratory diagnostic testing. 4. Improvement of organizational, methodological and informational activities. 5. Organization of laboratory supply for on-duty and emergency services. 6. Measures for improving the existing system of procurement in medical products. 7. Creation of scientific and technical policy in the field of clinical and laboratory services. The results of the Concept of national clinical laboratory service development implementation were summarized.
Headspace Analysis in the Study of Volatile Toxic Substances
Authors: Чеховский П.В. , Гурина М.А. , Походня Ю.Г. , Шилейко И.Д. , Чубуков А.М. , Соболенко В.М. , Юхнель О.М. 
Published: April 2023

Введение. Результаты выполнения химико-токсикологического анализа во многом определяются качеством осуществления преаналитического этапа лабораторного исследования. Применительно к исследованию в биологическом материале летучих токсических веществ эффективным методом подготовки проб считается парофазный анализ. Цель. Научно обосновать и разработать валидированный метод идентификации в моче летучих токсических веществ и количественного определения в ней ацетона с использованием технологии статического варианта парофазного анализа. Материалы и методы. Методом газожидкостной хроматографии с парофазным анализом исследована 41 проба мочи добровольцев: 36 проб с добавлением аналитов и(или) внутреннего стандарта и 5 проб, не содержащих аналитов и внутреннего стандарта. Результаты. Установлены условия хроматографического разделения летучих токсических веществ, разработан и валидирован метод идентификации в моче летучих токсических веществ и количественного определения ацетона на основе технологии статического варианта парофазного анализа. Заключение. Разработанный и валидированный метод идентификации в моче летучих токсических веществ позволил проводить эффективное хроматографическое разделение аналитов, определять количественное содержание ацетона и повысить в 2 раза эффективность выявления летучих токсических веществ в образцах мочи.
Introduction. The results of chemical and toxicological analysis are largely determined by the quality of pre-analytical stage of the laboratory study. With regard to the study of volatile toxic substances in biological material, headspace analysis is considered to be an effective method of sample preparation. Purpose. To substantiate scientifically and to work out a validated method for identification of volatile toxic substances and quantification of acetone in urine using the technology of a static version of headspace analysis. Materials and methods. Gas-liquid chromatography with headspace analysis was used to study 41 urine samples from volunteers: 36 samples with analytes and/or internal standard added and 5 samples with no analytes or internal standard added. Results. Conditions for chromatographic separation of volatile toxic substances were established; and a method for identifying volatile toxic substances in urine and quantifying acetone based on the technology of a static version of headspace analysis was developed and validated. Conclusion. The developed and validated method for identifying volatile toxic substances in urine allowed efficient chromatographic separation of analytes, quantification of acetone, and contributed to a 2-fold increase in the efficiency of detecting volatile toxic substances in urine samples.
حفيدتا دالية ابن عاصم الغرناطي الموشحتان دراسة في التشكيل الشعري
Authors: أ.م. د. يونس طركي سلّوم البجاري  
Published: April 2023

يتناول البحث دراسة التوالد في حفيدتي دالية ابن عاصم الغرناطي الموشحتين ، والتلبث عند التشكيل الشعري لهاتين الحفيدتين الموشحتين ، الموشحة الخضراء والموشحة الحمراء اللتين ولّدهما الشاعر من بنتي داليته:الخضراء -النونية- والحمراء- اللامية - .
وكتب ابن عاصم الغرناطي موشحتيه المولّدتين بمدادٍ غير المداد الأسود المعهود ، إذ كتب الأولى بالمداد الأخضر فأصبحت خضراء ونسجها على بحر البسيط أو الرجز ، وهي من حيث الشكل تتألف من ثلاثة أبيات : الأول منها كان مقدمة غزلية ، والثاني والثالث كانا في غرض المديح ومدح بهما السلطان يوسف بن نصر .
وكتب ابن عاصم الثانية بالمداد الأحمر فأضحت حمراء ونسجها على بحر الرجز او السريع ، وهي من حيث الشكل تتألف من ثلاثة أبيات أيضا:الاول منها كان مقدمة غزلية كسابقه في الموشحة الخضراء ، والثاني والثالث كانا في غرض المديح أيضاً ومدح بهما السلطان يوسف بن نصر أيضاً.
وأمّا من حيث المضامين فتتمحور الموشحتان الحفيدتان - الخضراء والحمراء - شأنهما شأن الدالية - الأم - والبنتين : الخضراء - النونية - والحمراء - اللامية – على مدح السلطان أبي الحجاج يوسف بن نصر .
ومن هنا كانت شخصيته تمثل بؤرتي الموشحتين الحفيدتين اللتين انطلق منهما الشاعر الوشّاح .