bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sarcosaprophagous Muscid Fly (Diptera: Muscidae) Assemblages Along an Anthropized Gradient in the Humid Chaco Ecoregion, Chaco Province, Argentina
Authors: Bertucci Sabrina Eliana , Dufek Matias Ignacio , Patitucci Luciano Damián 
Published: February 2023

AbstractDeforestation, agriculture, farmyard animal husbandry, and urbanization are known to be the main causes of biodiversity loss and habitat fragmentation. The present study evaluated the role of anthropization in modulating Muscidae (Diptera) assemblages in the Humid Chaco ecoregion of Argentina, by testing the biotic homogenization and intermediate disturbance hypotheses. The study focused on natural, rural, and urban habitats in San Lorenzo Department, Chaco Province, where sarcosaprophagous muscid flies were surveyed. A total of 1,343 muscid flies were captured and identified to 7 genera and 24 species and morphospecies. We observed the effect of anthropization on the structuring of the assemblages and the presence of exotic species associated with human activity resulting from biotic homogenization. The highest abundance was recorded in the urban habitat, while the highest species richness and diversity (Shannon-Wienner and Hill’s numbers) were found in the rural habitat, supporting the intermediate disturbance hypothesis. Several species are classified as indicators of habitat as well as according to their index of synanthropy. Our results provide valuable information about the use of sarcosaprophagous muscids as indicators of disturbance of natural habitats and about possible health risks related to this family of Calyptratae flies previously unsurveyed in northeastern Argentina. This information could be used in the ecological, agronomy, sanitary, and forensic fields.
Watching Turkish television dramas in Argentina: entangled proximities and resigned agency in global media flows
Authors: Wagner María Celeste , Kraidy Marwan M 
Published: February 2023

Abstract
For decades, the theory of cultural proximity, which states that audiences prefer culturally proximal content (Straubhaar, 1991), has remained a major framework to explain audience preferences. We show how transnational media flows have challenged its contemporary applicability. To probe this, we focus on a recent, intriguing, and still understudied development: the success of Turkish television dramas (dizi) in Latin America, the land where the telenovela was born. Drawing from 25 interviews conducted in 2018 and 2019 in Argentina, we develop the notion of “entangled proximities” to explain different viewership positionalities. Moreover, we show that audiences adopt a “resigned agency”: they experience pleasure while recognizing the role of market forces. Finally, we build on the cultural proximity theory by arguing that these contemporary audiences are instead driven by a desired proximity with both the past genre of the telenovela and with the past society depicted in it.
Multicolour optical variability monitoring of blazars with high time resolution
Authors: Chang X , Yi T F , Xiong D R , Liu C X , Yang X , Li H Z , Gong Y L , Na W W , Li Y , Chen Z H , Chen J P , Mao L S 
Published: February 2023

ABSTRACTWe carried out a high time-resolution, multicolour optical observing campaign for eight gamma-ray detected blazars during 2010–2020. We analyse flux variations, correlations between magnitudes and colours on different time-scales. Intraday variability is detected in all eight sources of our sample. A bluer-when-brighter (BWB) chromatic trend is dominant on intraday time-scales. On the short time-scales, the BWB trend only shows up in ON 231, 3C 279, BL Lacertae, and 1E 1458.8 + 2249. There is a BWB trend in 3C 279 on the long time-scale. We estimate the upper limits of black hole mass for three blazars (i.e. ON 321, 1ES 1426 + 42.8, PKS 1510-089) using variability time-scales. On 2010 April 13, a potential quasi-periodic oscillation (QPO) with the period of P = 48.67 ± 13.90 min is found in 1ES 1426 + 42.8. The light curve on 2021 March 16 further shows the existence of the QPO phenomenon. The QPO in this target deserves further observation and confirmation.
Modelling the accretion and feedback of supermassive black hole binaries in gas-rich galaxy mergers
Authors: Liao Shihong , Johansson Peter H , Mannerkoski Matias , Irodotou Dimitrios , Rizzuto Francesco Paolo , McAlpine Stuart , Rantala Antti , Rawlings Alexander , Sawala Till 
Published: February 2023

ABSTRACTWe introduce a new model for the accretion and feedback of supermassive black hole (SMBH) binaries to the ketju code, which enables us to resolve the evolution of SMBH binaries down to separations of tens of Schwarzschild radii in gas-rich galaxy mergers. Our subgrid binary accretion model extends the widely used Bondi–Hoyle–Lyttleton accretion into the binary phase and incorporates preferential mass accretion on to the secondary SMBH, which is motivated by results from small-scale hydrodynamical circumbinary disc simulations. We perform idealized gas-rich disc galaxy merger simulations using pure thermal or pure kinetic active galactic nuclei (AGNs) feedback. Our binary accretion model provides more physically motivated SMBH mass ratios, which are one of the key parameters for computing gravitational wave (GW) induced recoil velocities. The merger time-scales of our simulated SMBH binaries are in the range tmerge ∼ 10–400 Myr. Prograde in-plane equal-mass galaxy mergers lead to the shortest merger time-scales, as they experience the strongest starbursts, with the ensuing high stellar density resulting in a rapid SMBH coalescence. Compared to the thermal AGN feedback, the kinetic AGN feedback predicts longer merger time-scales and results in more core-like stellar profiles, as it is more effective in removing gas from the galaxy centre and quenching star formation. This suggests that the AGN feedback implementation plays a critical role in modelling SMBH coalescences. Our model will be useful for improving the modelling of SMBH mergers in gas-rich galaxies, the prime targets for the upcoming LISA GW observatory.
The fragility of thin discs in galaxies – I. Building tailored N-body galaxy models
Authors: Galán-de Anta Pablo M , Vasiliev Eugene , Sarzi Marc , Dotti Massimo , Capelo Pedro R , Incatasciato Andrea , Posti Lorenzo , Morelli Lorenzo , Corsini Enrico Maria 
Published: February 2023

ABSTRACT
Thin stellar discs on both galactic and nuclear, sub-kpc scales are believed to be fragile structures that would be easily destroyed in major mergers. In turn, this makes the age dating of their stellar populations a useful diagnostics for the assembly history of galaxies. We aim at carefully exploring the fragility of such stellar discs in intermediate- and low-mass encounters, using high-resolution N-body simulations of galaxy models with structural and kinematic properties tailored to actually observed galaxies. As a first but challenging step, we create a dynamical model of FCC 170, a nearly edge-on galaxy in the Fornax cluster with multiple galactic components and including both galactic-scale and nuclear stellar discs (NSDs), using detailed kinematic data from the Multi Unit Spectroscopic Explorer and a novel method for constructing distribution function-based self-consistent galaxy models. We then create N-body realizations of this model and demonstrate that it remains in equilibrium and preserves its properties over many Gyr, when evolved with a sufficiently high particle number. However, the NSD is more prone to numerical heating, which gradually increases its thickness by up to 22 per cent in 10 Gyr even in our highest resolution runs. Nevertheless, these N-body models can serve as realistic representations of actual galaxies in merger simulations.
PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression
Authors: Chembazhi Ullas Valiya , Tung Wesley S , Hwang Hyojeong , Wang Yuexi , Lalwani Aryan , Nguyen Ka Lam , Bangru Sushant , Yee Danielle , Chin Kristy , Yang Jing , Kalsotra Auinash , Mei Wenyan 
Published: February 2023

AbstractThe intestinal epithelial regeneration is driven by intestinal stem cells under homeostatic conditions. Differentiated intestinal epithelial cells, such as Paneth cells, are capable of acquiring multipotency and contributing to regeneration upon the loss of intestinal stem cells. Paneth cells also support intestinal stem cell survival and regeneration. We report here that depletion of an RNA-binding protein named polypyrimidine tract binding protein 1 (PTBP1) in mouse intestinal epithelial cells causes intestinal stem cell death and epithelial regeneration failure. Mechanistically, we show that PTBP1 inhibits neuronal-like splicing programs in intestinal crypt cells, which is critical for maintaining intestinal stem cell stemness. This function is achieved at least in part through promoting the non-productive splicing of its paralog PTBP2. Moreover, PTBP1 inhibits the expression of an AKT inhibitor PHLDA3 in Paneth cells and permits AKT activation, which presumably maintains Paneth cell plasticity and function in supporting intestinal stem cell niche. We show that PTBP1 directly binds to a CU-rich region in the 3′ UTR of Phlda3, which we demonstrate to be critical for downregulating the mRNA and protein levels of Phlda3. Our results thus reveal the multifaceted in vivo regulation of intestinal epithelial regeneration by PTBP1 at the post-transcriptional level.
Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis inPseudomonas aeruginosa
Authors: Pan Xiaolei , Liang Han , Zhao Xinrui , Zhang Qionglin , Chen Lei , Yue Zhuo , Yin Liwen , Jin Yongxin , Bai Fang , Cheng Zhihui , Bartlam Mark , Wu Weihui 
Published: February 2023

AbstractPseudomonas aeruginosa is capable of causing acute and chronic infections in various host tissues, which depends on its abilities to effectively utilize host-derived nutrients and produce protein virulence factors and toxic compounds. However, the regulatory mechanisms that direct metabolic intermediates towards production of toxic compounds are poorly understood. We previously identified a regulatory protein PvrA that controls genes involved in fatty acid catabolism by binding to palmitoyl-coenzyme A (CoA). In this study, transcriptomic analyses revealed that PvrA activates the Pseudomonas quinolone signal (PQS) synthesis genes, while suppressing genes for production of polyhydroxyalkanoates (PHAs). When palmitic acid was the sole carbon source, mutation of pvrA reduced production of pyocyanin and rhamnolipids due to defective PQS synthesis, but increased PHA production. We further solved the co-crystal structure of PvrA with palmitoyl-CoA and identified palmitoyl-CoA-binding residues. By using pvrA mutants, we verified the roles of the key palmitoyl-CoA-binding residues in gene regulation in response to palmitic acid. Since the PQS signal molecules, rhamnolipids and PHA synthesis pathways are interconnected by common metabolic intermediates, our results revealed a regulatory mechanism that directs carbon flux from carbon/energy storage to virulence factor production, which might be crucial for the pathogenesis.
A Network Analysis of Cigarette Craving
Authors: Aslan Mihaela , Sala Margaret , Gueorguieva Ralitza , Garrison Kathleen A 
Published: February 2023

Abstract

Introduction
Craving is considered a central process to addictive behavior including cigarette smoking, although the clinical utility of craving relies on how it is defined and measured. Network analysis enables examining the network structure of craving symptoms, identifying the most central symptoms of cigarette craving, and improving our understanding of craving and its measurement.

Aims and Methods
This study used network analysis to identify the central symptoms of self-reported cigarette craving as measured by the Craving Experience Questionnaire, which assesses both craving strength and craving frequency. Data were obtained from baseline of a randomized controlled trial of mindfulness training for smoking cessation.

Results
The most central symptoms in an overall cigarette craving network were the frequency of imagining its smell, imagining its taste, and intrusive thoughts. The most central symptoms of both craving frequency and craving strength sub-networks were imagining its taste, the urge to have it, and intrusive thoughts.

Conclusions
The most central craving symptoms reported by individuals in treatment for cigarette smoking were from the frequency domain, demonstrating the value of assessing craving frequency along with craving strength. Central craving symptoms included multisensory imagery (taste, smell), intrusive thoughts, and urge, providing additional evidence that these symptoms may be important to consider in craving measurement and intervention. Findings provide insight into the symptoms that are central to craving, contributing to a better understanding of cigarette cravings, and suggesting potential targets for clinical interventions.

Implications
This study used network analysis to identify central symptoms of cigarette craving. Both craving frequency and strength were assessed. The most central symptoms of cigarette craving were related to craving frequency. Central symptoms included multisensory imagery, intrusive thoughts, and urge. Central symptoms might be targeted by smoking cessation treatment.
Decision-Making and Health-Related Quality of Life in Patients with Melanoma Considering Adjuvant Immunotherapy
Authors: Atkinson Thomas M , Hay Jennifer L , Young Kim Soo , Schofield Elizabeth , Postow Michael A , Momtaz Parisa , Warner Allison Betof , Shoushtari Alexander N , Callahan Margaret K , Wolchok Jedd D , Li Yuelin , Chapman Paul B 
Published: February 2023

AbstractBackgroundAdjuvant anti-PD1 treatment improves relapse-free survival (RFS) but has not been shown to improve overall survival (OS) in melanoma and is associated with risks of immune-related adverse events (irAEs), some permanent. We identified factors patients consider in deciding whether to undergo adjuvant anti-PD1 treatment and assessed prospective health-related quality of life (HRQoL), treatment satisfaction, and decisional regret.Patients and MethodsPatients with stage IIIB-IV cutaneous melanoma and free of disease, were candidates for adjuvant anti-PD1 immunotherapy, and had not yet discussed adjuvant treatment options with their oncologist were eligible. Participants viewed a 4-minute informational video tailored to their disease stage which communicated comprehensive, quantitative information about the risk of relapse both with and without adjuvant treatment, and risks of each irAE before deciding whether or not to opt for adjuvant therapy. We collected data on demographics, HRQoL, and attitudes toward adjuvant treatment over 1 year.Results14/34 patients (41%) opted for adjuvant anti-PD1 immunotherapy, 20/34 (59%) opted for observation. Patients choosing adjuvant immunotherapy scored higher on HRQoL social well-being at pre-treatment, were more likely to endorse positive statements about adjuvant immunotherapy, and to perceive that their physician preferred adjuvant therapy. They had lower decisional regret and higher satisfaction, even if they experienced toxicity or recurrence.ConclusionsWhen provided with comprehensive quantitative information about risks and benefits of adjuvant anti-PD1 immunotherapy, 20/34 (59%) of patients opted for observation. Patients choosing adjuvant immunotherapy had lower decisional regret and higher satisfaction over time even if they had poorer outcomes in treatment.
Longitudinal proteomic investigation of COVID-19 vaccination
Authors: Wang Yingrui , Zhu Qianru , Sun Rui , Yi Xiao , Huang Lingling , Hu Yifan , Ge Weigang , Gao Huanhuan , Ye Xinfu , Song Yu , Shao Li , Li Yantao , Li Jie , Guo Tiannan , Shi Junping 
Published: February 2023

Abstract
Although the development of COVID-19 vaccines has been a remarkable success, the heterogeneous individual antibody generation and decline over time are unknown and still hard to predict. In this study, blood samples were collected from 163 participants who next received two doses of an inactivated COVID-19 vaccine (CoronaVac®) at a 28-day interval. Using TMT-based proteomics, we identified 1,715 serum and 7,342 peripheral blood mononuclear cells (PBMCs) proteins. We proposed two sets of potential biomarkers (seven from serum, five from PBMCs) at baseline using machine learning, and predicted the individual seropositivity 57 days after vaccination (AUC = 0.87). Based on the four PBMC’s potential biomarkers, we predicted the antibody persistence until 180 days after vaccination (AUC = 0.79). Our data highlighted characteristic hematological host responses, including altered lymphocyte migration regulation, neutrophil degranulation, and humoral immune response. This study proposed potential blood-derived protein biomarkers before vaccination for predicting heterogeneous antibody generation and decline after COVID-19 vaccination, shedding light on immunization mechanisms and individual booster shot planning.
Down the River: Glyphosate Use in Agriculture and Birth Outcomes of Surrounding Populations
Authors: Dias Mateus , Rocha Rudi , Soares Rodrigo R 
Published: February 2023

Abstract
This paper documents an externality from the agricultural use of the most widely applied herbicide in the world—glyphosate—on birth outcomes of surrounding populations. We focus on the subclinical effects of water contamination in areas distant from the original locations of application. Our identification relies on: (i) the regulation allowing the introduction of genetically modified seeds in Brazil; (ii) the potential gain in municipality-level productivity from adoption of genetically modified soybean seeds and the strong complementary between these seeds and glyphosate; and (iii) the direction of water flow within water basins. We document a significant deterioration in birth outcomes for populations downstream from locations that are likely to have increased relatively more the use of glyphosate. According to our preferred specification, the average increase in glyphosate use in the sample during 2000–10 period led to an increase of 5% of the average in infant mortality rate.
Reducing poverty and social exclusion in Europe: estimating the marginal effect of income on material deprivation
Authors: Notten Geranda , Guio Anne-Catherine 
Published: February 2023

Abstract
Advances in measuring poverty in non-monetary terms enable governments to track social progress on ends, the things that societies value doing and being. Using a national-level regression-based empirical strategy, this research demonstrates the magnitude of previously unmeasured policy effects on material deprivation, a non-monetary indicator of poverty. We apply this methodology to a comparative microdata set covering 32 European countries and estimate the average marginal effect of a small universal income increase on material deprivation. We illustrate the impact of the income transfer from various policy angles commonly used when analyzing the poverty reduction effects of social transfers. We show how impacts vary with characteristics such as country and household deprivation levels and the type of social transfers received. The methodology enables an analysis of the redistributive impact of social transfers on non-monetary social outcomes and is also suitable for other non-monetary social outcomes such as housing deprivation and food insecurity.
Feasibility of ultrasound in the diagnosis of neonatal respiratory distress syndrome in preterm infants
Authors: Zheng Lei , Jing Hongyan , Liu Lihong , Wang Lianyi 
Published: February 2023

Abstract

Background
The aim of this study was to investigate the feasibility of lung ultrasound in the diagnosis of neonatal respiratory distress syndrome (NRDS) in preterm infants.

Methods
One hundred and nine preterm infants were prospectively recruited. Three ultrasound diagnostic criteria were developed to diagnose preterm infants with NRDS: (A) thickened or not smooth pleural line, part of the lung field shows diffuse ‘B-line’ sign or alveolar-interstitial syndrome (AIS); (B) thickened or not smooth pleural line, all lung fields show AIS, signifying the ‘white lung’ sign; (C) thickened or rough pleural line, ‘white lung’ sign and ‘lung consolidation’ sign can be observed in any lung field.

Results
The sensitivity and negative predictive value of NRDS in preterm infants with diagnostic criteria A were 100%, but the specificity and positive predictive value were 67.95 and 55.36%, respectively. The specificity and positive predictive value of diagnostic criteria B and C were 100%, while the 95% CI of diagnostic criteria B was narrower than diagnostic criteria C. The sensitivity and negative predictive value of diagnostic criteria B were higher than that of diagnostic criteria C. Of the 31 NRDS cases, 15 cases had severe NRDS and the other 16 did not have severe NRDS.

Conclusion
Thickened or rough pleural line with white lung sign is an important characteristic for the diagnosis of NRDS by lung ultrasound. White lung sign combined with the lung consolidation sign had high diagnostic efficacy when distinguishing severe NRDS from not severe NRDS.
Mobile Broadband, Poverty, and Labor Outcomes in Tanzania
Authors: Bahia Kalvin , Castells Pau , Cruz Genaro , Masaki Takaaki , Rodríguez-Castelán Carlos , Sanfelice Viviane 
Published: February 2023

AbstractWhat are the impacts of expanding mobile broadband coverage on poverty, household consumption, and labor-market outcomes in developing countries? Who benefits from improved coverage of mobile internet? To respond to these questions, this paper applies a difference-in-differences estimation using panel household survey data combined with geospatial information on the rollout of mobile broadband coverage in Tanzania. The results reveal that being covered by 3G networks has a large positive effect on total household consumption and poverty reduction, driven by positive impacts on labor-market outcomes. Working-age individuals living in areas covered by mobile internet witnessed an increase in labor-force participation, wage employment, and non-farm self-employment, and a decline in farm employment. These effects vary by age, gender, and skill level. Younger and more skilled men benefit the most through higher labor-force participation and wage employment, while high-skilled women benefit from transitions from self-employed farm work into non-farm employment.