bluuebunny/crossref_metadata_2025_split huggingface dataset:
LOCAL WISDOM AS SOCIAL COHESION IN ESTABLISHING INTER-RELIGIOUS LIFE IN DONGGO, DISTRICT OF BIMA
Authors: Nuruddin Nuruddin 
Published: February 2023

Cultural values recently have been degraded, and have begun to be forgotten by society due to the times. Yet, apart from that, the certain cultures are very suitable to be developed and preserved. One of the benefits is to realize life together in the frame of religion plurality, realizing social harmonization is a necessity that must be lived by every individual or society. There are several villages in Bima, especially in Donggo that live in multicultural religion frame, one of which is in Mbawa, Tolo Nggeru and Palama Village. The religions that are believed by the community are Islam, Catholics and Protestant. In sulking inter-religion life, there must be a standard of togetherness values so as not bring up polemics in life. Therefore, we can see the social cohesion built by the inter-religious community in the region makes local wisdom a medium in sulking the values of religious moderation. In analysing this research, we used qualitative research with a phenomenological approach, and the process of collecting data through observation, documentation and interviews. Indeed, local wisdom made by community can be used by the community as a value of togetherness in the life inter-religious people. So the local wisdom used is the tradition of “tekara ne’e” and ”Mbolo weki”and open communication. Really helps the community in sulking the life of inter-religious society.
Demographic and Socioeconomic Determinants Are Associated with Poor Preoperative Patient-Reported Pain and Function in Primary TKA
Authors: Vega Jose , Emara Ahmed K. , Orr Melissa , Klika Alison K. , Piuzzi Nicolas S. ,   the Cleveland Clinic Arthroplasty Group
Published: February 2023

Background:
Pain and function, as reflected by patient-reported outcome measures (PROMs), can influence improvement after total knee arthroplasty (TKA) and can reflect the extent of patient access to orthopaedic surgical care. We aimed to (1) categorize patients according to pain and function PROM phenotypes, (2) identify patient characteristics associated with poor preoperative pain and function, and (3) assess relationships between baseline characteristics and PROM phenotypes.

Methods:
A prospective cohort of 14,079 TKAs was enrolled. Demographics, comorbidities, surgical details, and preoperative PROMs were collected. Outcomes included preoperative Knee injury and Osteoarthritis Outcome Score (KOOS) Pain (P) and Physical Function (PS) subscores, stratified by demographics. Patients were then categorized into 4 PROM phenotypes defined on the basis of the cohort medians: above or equal to the median for both pain and function scores (P+PS+), below the median for both pain and function (P−PS−), above or equal to the median for pain but below the median for function (P+PS−), and below the median for pain but above or equal to the median for function (P−PS+). Descriptive statistics and multivariable regression analyses were calculated.

Results:
The largest PROM phenotype was P−PS− (39.4%), followed by P+PS+ (38.9%). The cohort with discordantly poor function but high pain scores (less pain) was the smallest cohort (9.9%). Preoperative KOOS-Pain and KOOS-PS scores at or below the 25th percentile were independently associated with younger age, female sex, higher body mass index (BMI), non-White race, current smoking, lower education, non-commercial insurance, and higher Charlson Comorbidity Index (CCI). Multivariate logistic regression showed that patients in the P+PS+ category were older (odds ratio [OR] = 1.56), were more likely to be male (OR = 2.00), had a lower BMI (OR = 0.67), had more education (OR = 1.63), had a lower CCI, and were less likely to be Black (OR = 0.80) or Other (OR = 0.62) race, be a current smoker (OR = 0.62), and have commercial insurance (OR = 0.74), compared with the P−PS− phenotype.

Conclusions:
Younger age, obesity, non-White race, female sex, current or recent smoking, non-commercial insurance, and higher CCI were associated with worse pre-TKA PROMs and poor pain-function phenotype combinations. Such a pattern may indicate barriers to TKA access among these patient populations leading to advanced levels of impairment at the time of treatment.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Lateral Patellar Instability
Authors: Drapeau-Zgoralski Véronique , Swift Brendan , Caines Andrew , Kerrigan Alicia , Carsen Sasha , Pickell Michael 
Published: February 2023

➤ Patellar instability represents a common problem with an evolving understanding and multifactorial pathoetiology. Treatment plans should be based on the identification of contributing anatomical factors and tailored to each individual patient.➤ Risks for recurrent instability are dependent on several patient-specific factors including patella alta, increased tibial tubercle-to-trochlear groove (TT-TG) distance, trochlear dysplasia, younger skeletal age, and ligamentous laxity.➤ Cartilage or osteochondral lesions and/or fractures are commonly observed in first-time patellar dislocation, and magnetic resonance imaging (MRI) should be strongly considered. Advanced imaging modalities, such as computed tomography (CT) or MRI, should also be obtained preoperatively to identify predisposing factors and guide surgical treatment.➤ Medial patellofemoral ligament (MPFL) reconstruction with anatomical femoral tunnel positioning is associated with lower recurrence rates compared with MPFL repair and has become a common and successful reconstructive surgical option in cases of instability.➤ Lateral retinacular tightness can be addressed with lateral retinacular release or lengthening, but these procedures should not be performed in isolation.➤ Tibial tubercle osteotomy is a powerful reconstructive tool in the setting of underlying skeletal risk factors for instability and can be of particular benefit in the presence of increased TT-TG distance (>20 mm), and/or in the setting of patella alta.➤ The indications for trochleoplasty are still developing along with the clinical evidence, but trochleoplasty may be indicated in some cases of severe trochlear dysplasia. Several surgical techniques have indications in specific clinical scenarios and populations, and indications, risks, and benefits to each are progressing with our understanding.➤ Combined femoral derotational osteotomy and MPFL reconstruction can be considered for patients with a femoral anteversion angle of >30° to improve patient outcomes and reduce recurrence rates.
There Must Be a Better Way
Authors: Lieber Richard L. 
Published: February 2023

Abstract:
The National Institutes of Health (NIH) R01 grant represents the gold standard for research independence across the United States. The barrier to entry for this grant mechanism is extremely high, with <10% of grants being funded. Interestingly, after this tremendously high barrier, there is very little accountability for the grantee to accomplish the aims that were originally proposed. While there is certainly value to requiring investigators to provide a logical and compelling research plan, excessive grant writing creates a large inefficiency. Thus, a “fail quickly” model, which is not without cost, should be considered. Such a model involves a much lower barrier to entry and much higher short-term accountability so that more aims can be tested in less time at lower cost.
A novel decision-making approach based on sine trigonometric cubic Pythagorean fuzzy aggregation operators
Authors: Rahim Muhammad , Amin Fazli , Ali Asad 
Published: February 2023

Abstract
The objective of this study is to imitate several efficient sine-trigonometric operational laws to handle the decision-making process under the cubic Pythagorean fuzzy set environment. The sine-trigonometric function provides the periodicity and symmetry of the origin in nature and satisfies the potentials of decision-makers over the considerations of the decision-making process. keeping the advantages of the sine function and the significance of the cubic Pythagorean fuzzy set, we demonstrate the novel sine trigonometric operational laws under the cubic Pythagorean fuzzy environment. Based on these operational laws, novel sine trigonometric cubic Pythagorean fuzzy aggregation operators are developed. This study mainly focuses on a decision-making approach for multi-criteria decision-making problems that is based on proposed aggregation operators with given weight information of the criterion. Lastly, to demonstrate the efficiency, an illustration is presented. Sensitivity and comparison analyses are used to evaluate the method’s permanency and rationality.
A Fully Autonomous Robotic Ultrasound System for Thyroid Scanning
Authors: Su Kang , Liu Jingwei , Ren Xiaoqi , Huo Yingxiang , Du Guanglong , Zhao Wei , Wang Xueqian , Liang Bin , Li Di , Liu Peter 
Published: February 2023

Abstract

The current thyroid ultrasound relies heavily on the experience of the sonographer and radiologist, which would be physically and cognitively exhausting. Here we report a novel fully autonomous robotic ultrasound system (FARUS) that can scan thyroid regions without human assistance. In this application, human skeleton point recognition, image segmentation, and force feedback are used to solve the problem of thyroid localization. The orientation of the ultrasound probe is adjusted via Bayesian optimization. By using FARUS, both transverse and longitudinal scanning of thyroid tissue can be performed, as well as real-time thyroid nodule detection with artificial intelligence (AI) algorithms. Experimental results on human participants demonstrate that FARUS can perform high-quality ultrasound scans in comparison with manual scans obtained by clinicians.
Identification of Immune-Related Target and Prognostic Biomarkers in PBMC of hepatocellular carcinoma
Authors: Hu Rui , Zhang Wei , Ma Mengqing , Huang Qi , Lv Minling , Ma Wenfeng , Sun Xinfeng , Feng Wenxing , Li Jing , Zhong Xin , Sun Jialing , Yao Wei , Zhou Xiaozhou , Han Zhiyi 
Published: February 2023

Abstract
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and is characterized by insidious onset, rapid progression and poor prognosis. In recent years, several biomarkers have been identified for early screening of HCC, although novel prognostic biomarkers still need to be explored. In this study, we compared the transcriptomes of 6 deceased and 6 living HCC patients using DESeq2, edgeR and Limma programs, and identified 43 differentially expressed genes (DEGs). The top 10 DEGs were validated by RNA-Seq analysis of peripheral blood mononuclear cells (PBMCs) isolated from HCC patients of different BCLC stages. The expression levels of METTL7B, CLDN18, SOCS3, ITGA9 and RNASE3 correlated positively with the BCLC stage. Moreover, CLDN18 proteins were significantly upregulated in the tumor tissues, but also associated with HCC stage, tumor grade and poor prognosis. Functional annotation of CLDN18 in HCC revealed enrichment of the cellular senescence, mRNA surveillance, metabolism of xenobiotics by cytochrome P450 and Human T-cell leukemia virus 1 infection pathways, along with biological processes such as cell cycle, inflammatory response and cellular ketone metabolism. In addition, CLDN18 was also associated with tumor infiltrating immune cells, suppressive immune cell markers, T lymphocyte depletion and activation of HCC, and low expression of CLDN18 was associated with higher CD8+T cell infiltration and better survival rates. These results suggest that CLDN18 is a potential prognostic marker and immunotherapeutic target for HCC.
Transition models of care for Type 1 Diabetes: a systematic review
Authors: Zurynski Yvonne , Carrigan Ann , Meulenbroeks Isabelle , Sarkies Mitchell N , Dammery Genevieve , Halim Nicole , Lake Rebecca , Davis Elizabeth , Jones Timothy W , Braithwaite Jeffrey 
Published: February 2023

Abstract
Background
Managing the care regimen for Type 1 Diabetes (T1D) is challenging for emerging adults, as they take on greater responsibility for self-management. A diverse range of models of care have been implemented to improve safety and quality of care during transition between paediatric and adult services. However, evidence about acceptability and effectiveness of these is limited. Our aim was to synthesize the evidence for transition models and their components, examine the health related and psychosocial outcomes, and to identify determinants associated with the implementation of person-centred models of transition care.
Method
We searched Medline, CINAHL, EMBASE and Scopus. Peer reviewed empirical studies that focused on T1D models of care published from 2010 to 2021 in English, reporting experimental, qualitative, mixed methods, and observational studies were included.
Results
Fourteen studies reported on health and psychosocial outcomes, and engagement with healthcare. Three key models of care emerged: structured transition education programs (6 studies), multidisciplinary team (MDT) transition support (5 studies) and telehealth/virtual care as an integral component of a broader model (3 studies). Compared with usual practice, three of the six structured transition education programs led to improved maintenance of glycaemic control, improved psychological well-being, and improved engagement with health services. Four MDT transition care models reported improved health outcomes, and improved engagement with health services, however, three studies reported no benefit. Reduced diabetes related stress and increased patient satisfaction were reported by two studies, but three reported no benefit. Telehealth and virtual group appointments improved adherence to self-management and reduced diabetes distress but no change in health outcomes. No study reported on implementation determinants or applied an implementation framework to guide their research.
Conclusions
Although some health and psychosocial benefits are reported, the results were mixed. No studies reported on T1D transition model implementation outcomes such as acceptability, adoption, and appropriateness among clinicians or managers implementing these models. This gap needs to be addressed to support future adoption of successful models.
The safety and tolerability of Annona muricata leaf product in people living with cancer: study protocol
Authors: Chan Wai-Jo Jocelin , Beale Philip , McLachlan Andrew J , Hanrahan Jane R , Harnett Joanna E 
Published: February 2023

Abstract

Background: Annona muricata, also known as graviola, soursop and guanabana is a herbal product used by people living with cancer. Anecdotal clinical evidence suggests this herb has potential anti-cancer activity. There are numerous pre-clinical studies detailing Annona muricata’s main bioactive constituents. To date, clinical studies evaluating the efficacy, safety and tolerability are limited. This study aims to investigate the safety and tolerability of Annona muricata leaf in people living with advanced malignancy.
Methods: This open label pilot study will involve people living with stage III and IV cancers of any type, who are not undergoing chemotherapeutic treatment. The primary outcome is safety and tolerability of an Annona muricata leaf product in this population assessed by participants’ self-reporting of adverse effects experienced and the proportion of participants completing the study. Secondary outcomes include biomarkers of inflammation and immune function, disease status and self-reported quality of life scores. Participants (n = 24) will be allocated to one of two groups for 12 weeks. Participants will commence at different timepoints and be assigned to either 530 mg or 1060 mg of Annona muricata daily. The study has been approved by the Human Research Ethics Committee Bellberry (2022-04-420) and will be conducted in compliance with the SPIRIT statement.
Discussion: The results of this study will provide safety and tolerability data for clinicians involved in the care of people living with cancer who choose to use Annona muricata products as an integrative approach to their healthcare. The results of this study will inform further research about the potential role of Annona muricata in cancer.
Trial registration: This study has been registered with the Australian New Zealand Clinical Trials Register (ACTRN 12622001288718)
A Torsional Pneumatic Joint for Spacesuit Inspired with Origami Structure
Authors: Shang Kun , Li Meng , Yang Hong-Rui , Liu Shao-Jie 
Published: February 2023

Abstract
For exploration of the deep space destinations like the planetary surfaces, one of the most significant challenges is the performance of the spacesuit system. Aimed at improving safety and flexibility for the human-suit system during extravehicular activities (EVAs), a novel torsional pneumatic joint (TP joint) is proposed inspired with origami structure, overcoming the defects of traditional airtight bearings. Geometry of the TP joint is designed with Kresling crease pattern at first. To study the mechanical property of the TP joint, a basic structure of two layers is abstracted and analyzed with the energy method and nonlinear finite element method. According to analysis, the constitution of resistance torque is discussed and two influence factors of material rigidness and air pressure are investigated. As the inner pressure becomes large, the inflatable structure is unstable and tends to swell asymmetrically. Meanwhile, based on an eight-layer prototype joint, torsional and bending tests are conducted under inner pressure to examine the mobility of the joint. Results show that the prototype joint can be twisted to a range of 40°in one direction, and the torque is much smaller than the critical buckling torque of a pneumatic tube. Besides, the prototype joint also equips the bending function with a relatively low torque as an ordinary soft spacesuit joint. Thereby, the proposed TP joint can realized the torsional operations and has the potential to function as rigid bearings. Besides, the TP joint can be designed as a multi-degree joint to provide more mobility for the spacesuit system.
Strategic feeding of the prepubertal Nellore heifers improves body development and increases the number of recovered oocytes, viable oocytes and embryos produced in vitro.
Authors: Toledo Ricardo Braz , de Faria Otávio Augusto Costa , Leme Ligiane Oliveira , Magnabosco Cláudio Ulhoa , Guimarães Roberto , Eifert Eduardo da Costa , Santos Isabella Rodrigues dos , Oliveira Rodrigo Vidal , Dode Margot Alves Nunes , Malaquias Juaci Vitoria , Pivato Ivo , Martins Carlos Frederico 
Published: February 2023

Abstract
The objective of this work was to determine the effect of two different feeding plans on quantity and quality of oocytes and in vitro embryo production, as well as on the body development of prepubertal Nellore heifers. After weaning, thirty-three Nellore heifers were divided into two experimental groups and supplemented with two nutritional plans according to dry and rainy seasons. For nutritional plan 2 the animals received diets containing 26% and 19% more metabolizable energy (ME) related to NP1 in the dry and rainy seasons, respectively. After 3.5 months of supplementation (i.e., at 10 months old), animals from both groups underwent follicular aspiration (OPU) every 21 days and in vitro produced embryos (IEP). Withers height, chest depth and body weight of all animals were measured monthly. Subcutaneous fat deposition was measured at the end of the study by ultrasonography. The number of retrieved COCs per OPU and viable oocytes was respectively 49% and 42% greater in NP2 heifers (p=0.018 and p=0.049). Regarding the blastocysts rate, heifers administered NP2 produced 29.7% of blastocysts, a percentage higher than NP1 treatment animals that produced 24.40% of embryos (p<0.05). Consequently, the females from NP2 treatment presented a greater final weight, chest depth, carcass finish, in addition to a greater accumulation of subcutaneous fat. These results indicating a positive effect of diet slightly higher in energy in the assisted reproduction of Nellore prepubertal heifers and also on weight gain and fat deposition in the carcass, allowing these females to reach the suggested early mating conditions.
Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition
Authors: Wang Yiming , Jing Lin , Lei Xiao , Ma Zhen , Li Bei , Shi Yuanyuan , zhang Wuyang , Li Yuan , Zhou Hongzhi , Hu Kaijin , Xue Yang , Jin Yan 
Published: February 2023

Abstract
Background: Delayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring great distress to patients. In diabetic patients, macrophages accumulate around skin wounds and produce NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasomes, which in turn undergo pyroptosis and produce inflammatory factors such as interleukin-1β that affect wound healing. Although our previous study revealed that apoptotic extracellular vesicles (ApoEVs) produced from mesenchymal stem cells (MSCs) improve cutaneous wound healing in normal C57BL/6 mice, whether ApoEVs can also improve diabetic wound healing remains unclear.
Methods: Umbilical cord mesenchymal stem cells (UCMSCs) were cultured in vitro and apoptosis was induced. ApoEVs were extracted and identified and used in a T2DM mouse cutaneous wound model to evaluate the efficacy. The inhibitory effect of ApoEVs on macrophage pyroptosis was verified in vivo and in vitro, and the level of oxidative stress in macrophages was assessed to explore the mechanism by which ApoEVs play a role.
Results: UCMSC-derived ApoEVs improved skin defect healing in T2DM mice. Moreover, UCMSC-derived ApoEVs inhibited macrophage pyroptosis in T2DM mice in vivo as well as in vitro under high glucose culture conditions. In addition, we demonstrated that ApoEVs reduce oxidative stress levels, which is a possible mechanism by which they inhibit macrophage pyroptosis.
Conclusions:Our study confirmed that local application of UCMSC-derived ApoEVs improved cutaneous wound healing in T2DM mice. ApoEVs, as products of MSC apoptosis, can inhibit macrophage pyroptosis and regulate the death process by decreasing the level of oxidative stress.