bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic effects of previous cancer history on patients with major salivary gland cancer
Authors: Li Junhong , Rao Yufang , Wang Xiaoyu , Yu Libo , Qiu Ke , Mao Minzi , Song Yao , Pang Wendu , Cheng Danni , Zhang Yuyang , Feng Lan , Wang Xinyi , Shao Xiuli , Luo Yaxin , Zheng Yongbo , Li Xiaohong , Xu Yanhong , Xu Wei , Zhao Yu , Ren Jianjun 
Published: February 2023

AbstractObjectivesTo explore the prognostic effects of previous cancer history on patients with major salivary gland cancer (SGC).Subjects and MethodsSGC patients with (sec‐SGC) and without (one‐SGC) a previous cancer from the SEER database were identified. Cox proportional hazards regression (CoxPH) models were used to compare the prognosis between sec‐SGC and one‐SGC patients. Subgroup analyses for sec‐SGC patients by gender, previous cancer types, previous cancer histology, and cancer diagnosis interval (CDI) were performed. Two CoxPH models were constructed to distinguish sec‐SGC patients with different prognostic risks.Results9098 SGC patients were enrolled. Overall, sec‐SGC patients (adjusted HR [aHR] = 1.26,p < 0.001), especially those with a CDI ≤ 5 years (aHR = 1.47,p < 0.001), had worse overall survival (OS) than one‐SGC patients. In subgroup analysis, only sec‐SGC patients with a previous head and neck cancer who were female (aHR = 2.38,p = 0.005), with a CDI ≤ 5 years (aHR = 1.65,p = 0.007) or with a previous squamous cell carcinoma (aHR = 6.52,p < 0.001) had worse OS. Our models successfully differentiated all sec‐SGC patients into high‐, intermediate‐ and low‐risk groups with different prognosis.ConclusionsSec‐SGC patients with different previous cancer types, gender, CDI and previous cancer histology had varied prognosis. The models we constructed could help differentiate the prognosis of sec‐SGC patients with different risks.
Genotyping of DNA pools identifies untapped landraces and genomic regions to develop next‐generation varieties
Authors: Arca Mariangela , Gouesnard Brigitte , Mary‐Huard Tristan , Le Paslier Marie‐Christine , Bauland Cyril , Combes Valérie , Madur Delphine , Charcosset Alain , Nicolas Stéphane D. 
Published: February 2023

SummaryLandraces, that is, traditional varieties, have a large diversity that is underexploited in modern breeding. A novel DNA pooling strategy was implemented to identify promising landraces and genomic regions to enlarge the genetic diversity of modern varieties. As proof of concept, DNA pools from 156 American and European maize landraces representing 2340 individuals were genotyped with an SNP array to assess their genome‐wide diversity. They were compared to elite cultivars produced across the 20th century, represented by 327 inbred lines. Detection of selective footprints between landraces of different geographic origin identified genes involved in environmental adaptation (flowering times, growth) and tolerance to abiotic and biotic stress (drought, cold, salinity). Promising landraces were identified by developing two novel indicators that estimate their contribution to the genome of inbred lines: (i) a modified Roger's distance standardized by gene diversity and (ii) the assignation of lines to landraces using supervised analysis. It showed that most landraces do not have closely related lines and that only 10 landraces, including famous landraces as Reid's Yellow Dent, Lancaster Surecrop and Lacaune, cumulated half of the total contribution to inbred lines. Comparison of ancestral lines directly derived from landraces with lines from more advanced breeding cycles showed a decrease in the number of landraces with a large contribution. New inbred lines derived from landraces with limited contributions enriched more the haplotype diversity of reference inbred lines than those with a high contribution. Our approach opens an avenue for the identification of promising landraces for pre‐breeding.
Editorial synthesis for 2 in 2023 a collaboration between IARR's two journals: Recognizing the need for greater inclusivity in relationship science
Authors: Randall Ashley K. , Curran Melissa A. 
Published: February 2023

AbstractThe idea for this special issue came from the current Editors of the Journal for Social and Personal Relationships and Personal Relationships, who wanted to forge a collaboration between the International Association for Relationship Research's two journals. The timing of such collaboration came at a time when issues surrounding diversity, equity, and inclusion were being brought to light in science, broadly defined. Stemming from such discussions, for this special issue, we asked 10 sets of authors to apply an intersectional lens—grounded in Crenshaw's (1989, 1991) definition of intersectionality and drawing from questions posed by Cole (2009)—in their systematic review of literature from the past 20 years (1992–2022) and to answer these three questions: (1) from whose vantage point is the research being conducted, (2) what types of questions are valued, and (3) who is included in the research vs. who is being left out/whose voices are missing. Reviews for the special issue include these topics: (a) affectionate communication, health, and relationships, (b) romantic relationship maintenance behaviors, (c) relationship maintenance among military couples, (d) relational sacrifices, (e) LGBTQ‐inclusive research, (f) stress, support, and coping for romantic couples, (g) daily stress and romantic relationship quality, (h) infidelity, (i) relationship dissolution, and (j) the longitudinal study of romantic close relationships. Across the reviews, authors noted many of the same patterns; most studies included samples from the United States, wherein participants identified as White, heterosexual, and/or female; however, military samples were dominated by men. The methods employed were largely quantitative, cross‐sectional, and/or with data coming from surveys. Observations during the review process included the role of positionality as well as greater knowledge gained about the critical framework of intersectionality, specifically acknowledging that elements of diversity in sampling methods are not an application of intersectionality; rather, intersectionality places central focus on (a) how multiply marginalized social identities have been historically oppressed and (b) how systems of power, oppression, and privilege construct, reproduce, and sustain those multiply marginalized social identities. Recommendations for future relationship science are presented, specifically in how our fields can benefit from learning from the lens of intersectionality.
The associations of objective and perceived neighborhood disadvantage with stress among pregnant black women
Authors: Vaughan Sarah E. , Misra Dawn P. , Gohar Jazib , Hyer Suzanne , Price Mercedes , Giurgescu Carmen 
Published: February 2023

AbstractBackgroundNeighborhood disadvantage may impact risk of preterm birth through stress. Few studies have examined how neighborhood disadvantage relates to stress during pregnancy, especially for Black women.MethodsSecondary data analysis of 572 women in a prospective cohort in Detroit, MI and Columbus, OH. Participants completed questionnaires including the ROSS Neighborhood Disorder Scale, the crime subscale of the Perceived Neighborhood Scale (PNS), and the Perceived Stress Scale. An objective neighborhood disadvantage index (NDI) was created using principal components analysis after geocoding residential addresses and linking to Census data.ResultsAll models used logistic regression. Adjusted for maternal age and annual household income, perceived stress was positively associated with perceived neighborhood disorder (p < .01). In a separate model, perceived neighborhood crime was positively associated with perceived neighborhood disorder (p = .005). In a joint model adjusted for age and income, the association of disorder with stress was similar in magnitude (p < .01) but the association between crime and stress weakened. The NDI was not associated with perceived stress before or after adjustment for confounders.ConclusionsPerceived neighborhood disadvantage may capture a different dimension than objective neighborhood disadvantage. Future studies should test stress as a pathway by which neighborhood environment increases risk of preterm birth.
Trends in survival of children with severe congenital heart defects by gestational age at birth: A population‐based study using administrative hospital data for England
Authors: Gimeno Laura , Brown Katherine , Harron Katie , Peppa Maria , Gilbert Ruth , Blackburn Ruth 
Published: February 2023

AbstractBackgroundChildren with congenital heart defects (CHD) are twice as likely as their peers to be born preterm (<37 weeks' gestation), yet descriptions of recent trends in long‐term survival by gestational age at birth (GA) are lacking.ObjectivesTo quantify changes in survival to age 5 years of children in England with severe CHD by GA.MethodsWe estimated changes in survival to age five of children with severe CHD and all other children born in England between April 2004 and March 2016, overall and by GA‐group using linked hospital and mortality records.ResultsOf 5,953,598 livebirths, 5.7% (339,080 of 5,953,598) were born preterm, 0.35% (20,648 of 5,953,598) died before age five and 3.6 per 1000 (21,291 of 5,953,598) had severe CHD. Adjusting for GA, under‐five mortality rates fell at a similar rate between 2004–2008 and 2012–2016 for children with severe CHD (adjusted hazard ratio [HR] 0.79, 95% CI 0.71, 0.88) and all other children (HR 0.78, 95% CI 0.76, 0.81). For children with severe CHD, overall survival to age five increased from 87.5% (95% CI 86.6, 88.4) in 2004–2008 to 89.6% (95% CI 88.9, 90.3) in 2012–2016. There was strong evidence for better survival in the ≥39‐week group (90.2%, 95% CI 89.1, 91.2 to 93%, 95% CI 92.4, 93.9), weaker evidence at 24–31 and 37–38 weeks and no evidence at 32–36 weeks. We estimate that 51 deaths (95% CI 24, 77) per year in children with severe CHD were averted in 2012–2016 compared to what would have been the case had 2004–2008 mortality rates persisted.ConclusionsNine out of 10 children with severe CHD in 2012–2016 survived to age five. The small improvement in survival over the study period was driven by increased survival in term children. Most children with severe CHD are reaching school age and may require additional support by schools and healthcare services.
Decree or democracy? State takeovers and local government financial outcomes
Authors: Singla Akheil , Spreen Thomas Luke , Shumberger Jason 
Published: February 2023

AbstractMany states possess the authority to intervene in local fiscal emergencies, in some cases curtailing decision‐making powers of local officials through the appointment of an emergency financial manager. Previous research has recognized that these managers can push through unpopular reforms that may improve financial health but come at the expense of local control and democratic accountability. We assess the financial outcomes after eight recent state takeovers relative to a matched counterfactual comprised of similarly distressed general purpose local governments. The staggered difference‐in‐differences analysis shows emergency managers improve budgetary solvency and increase fiscal reserves. These enhancements are achieved through significant reduction of general fund expenditures. Several long‐term indicators show deterioration in financial health after state intervention reflecting a significant decline in long‐term assets. Overall, municipalities subjected to a state takeover did not realize significant long‐run improvements in financial health indicators relative to counterfactual governments.
A compliance—integrity framework for ethics management: An empirical analysis of local government practice
Authors: Perlman Bruce J. , Reddick Christopher , Demir Tansu 
Published: February 2023

AbstractThis article examines two approaches to ethics management found in the literature: compliance‐based and integrity‐based, often called the low road and high road. It asks whether both approaches genuinely exist in practice as the literature suggests and whether they are distinct. Data were collected in a national survey of 764 International City/County Management Association (ICMA) Chief Administrative Officers (CAOs) on ethics management practices in their local government to find evidence of the approaches. A Structural Equation Modeling (SEM) analysis showed that CAOs use both compliance‐based ethics, focusing on enforceable rules, and integrity‐based ethics, concentrating on instilling values. Our confirmatory factor analysis showed that both approaches are used in practice, are separate and distinct, but that they are highly correlated. This implies that both approaches are needed to understand ethics management properly. The results challenge existing literature focusing on one approach being dominant and show that both ethics management systems are essential.
The limited impact of reference groups' symbolic gender representation on willingness to coproduce
Authors: Sievert Martin 
Published: February 2023

AbstractPrevious literature presents a strong rationale for the positive impact of symbolic representation in coproduction contexts. However, empirical studies yield inconclusive findings indicating that meaningful effects are limited if citizens face high levels of uncertainty. This article combines symbolic representation with signaling theory, suggesting that the representativeness of central reference groups might reduce uncertainty. The theoretical framework suggests that the representation of supervisors and existing coproducers might positively affect citizens' willingness to coproduce. Contrary to the theoretical expectations, the empirical results from two preregistered factorial survey experiments (n = 2979), situated in prisoner rehabilitation and refugee integration, indicate that the symbolic gender representation of these reference groups has a limited impact. Only a balanced representation of coproducers exhibits a positive treatment effect on citizens' willingness to coproduce. The results oppose central arguments in the representative bureaucracy literature. At least for gender categories, symbolic representation is less important than expected.
Role of reinforcement learning for risk‐based robust control of cyber‐physical energy systems
Authors: Du Yan , Chatterjee Samrat , Bhattacharya Arnab , Dutta Ashutosh , Halappanavar Mahantesh 
Published: February 2023

AbstractCritical infrastructures such as cyber‐physical energy systems (CPS‐E) integrate information flow and physical operations that are vulnerable to natural and targeted failures. Safe, secure, and reliable operation and control of CPS‐E is critical to ensure societal well‐being and economic prosperity. Automated control is key for real‐time operations and may be mathematically cast as a sequential decision‐making problem under uncertainty. Emergence of data‐driven techniques for decision making under uncertainty, such as reinforcement learning (RL), have led to promising advances for addressing sequential decision‐making problems for risk‐based robust CPS‐E control. However, existing research challenges include understanding the applicability of RL methods across diverse CPS‐E applications, addressing the effect of risk preferences across multiple RL methods, and development of open‐source domain‐aware simulation environments for RL experimentation within a CPS‐E context. This article systematically analyzes the applicability of four types of RL methods (model‐free, model‐based, hybrid model‐free and model‐based, and hierarchical) for risk‐based robust CPS‐E control. Problem features and solution stability for the RL methods are also discussed. We demonstrate and compare the performance of multiple RL methods under different risk specifications (risk‐averse, risk‐neutral, and risk‐seeking) through the development and application of an open‐source simulation environment. Motivating numerical simulation examples include representative single‐zone and multizone building control use cases. Finally, six key insights for future research and broader adoption of RL methods are identified, with specific emphasis on problem features, algorithmic explainability, and solution stability.
“I think I might be a bit wobbly in my corona moral” – young people's moral functioning during the COVID‐19 lockdown: A social representations approach
Authors: Christensen Sarah H. , Gleibs Ilka H. 
Published: February 2023

In this paper, we use social representations theory to examine how young people made sense of COVID‐19 and the emergent behavioral guidelines during the lockdown in Denmark in Spring 2020. Further, we discuss how this informed their moral functioning. This research is explored through triangulation, investigating how COVID‐19 was represented in central speeches by Danish leaders (N = 4) and by young people in focus groups (n = 5,N = 25) and individual interviews (N = 10). Results suggest that young people's moral functioning during COVID‐19 depended on multiple, often polemic, representations. Consequently, their moral functioning was found to be an ambivalent practice, resulting in coping strategies of adaptation to their surroundings and othering fellow citizens deviating from the guidelines. In this context, coherent communication by authorities and community values are identified as key to promoting behavior change. As the social impact of COVID‐19 is unprecedented in many societies, including the Danish, this study contributes to the field of emerging infectious diseases providing insights that are essential for the continued management of this and future pandemics.
Cultural differences in maternal emotion control values and children's expressive flexibility
Authors: Son Heimi , Doan Stacey N. 
Published: February 2023

AbstractExpressive flexibility is the ability to express or suppress one's emotions to meet the demands of the situation. Recent work suggests that expressive flexibility is associated with better adjustment. However, few studies have focused on expressive flexibility in children. In addition, there is a dearth of research on possible correlates, such as culture, parental emotion socialization, and socioeconomic status, that may be associated with expressive flexibility competencies in children. The purpose of this study was to investigate cultural differences in children's expressive flexibility, maternal emotion control values (ECVs), and their relations to family socioeconomic status (SES) during middle childhood in a sample of European American (N = 31, M age = 9.61 years; 54.8% males), Korean American (N = 38, M age = 9.16 years; 55.3% males) and South Korean children (N = 77, M age = 9.74 years; 51.9% males). Mothers reported on demographics and their emotion control values. Children's expressive flexibility ability was assessed using a lab‐based observational measure. Multivariate analyses of covariance controlling for SES, child age, and gender suggested significant cultural differences in expressive flexibility, with the U.S. children (both European and Korean Americans) scoring higher on expressive flexibility compared to their South Korean counterparts. Results also suggested significant cultural differences regarding maternal ECVs; Korean Americans were more similar to South Koreans, both scoring higher on ECVs than European Americans. Socioeconomic status, but not maternal ECVs, were associated with children's expressive flexibility, independent of child age, sex, and culture.
Canine squamous cell carcinoma: Electrochemotherapy association with surgery and correlation with overall survival
Authors: de Castro Cunha Rúbia Monteiro , Lavalle Gleidice Eunice , Nunes Fernanda Camargo , de Oliveira Ayisa Rodrigues , de Lima Santos Renato , de Araújo Roberto Baracat 
Published: February 2023

AbstractSquamous cell carcinoma (SCC) is an important malignancy in dogs, due to its incidence and clinical presentation, which can be of locally aggressive single or multiple lesions with a metastatic potential. The objective of this investigation was to evaluate SCC response to treatment, anatomopathological and immunohistochemical characteristics, disease‐free interval and overall survival time. 54 dogs with histopathologically diagnosed SCC were included in this study. Their mean age was 9.16 years with a range of 1–14 years. Of the 54 animals in the study, 34 (65.4%) had white skin and white fur coats. There was a significant correlation between fur coat colour and the development of tumours in areas of sun exposure (p = .001). Animals with tumours in areas of the body exposed to the sun had longer overall survival time than animals with tumours in areas not associated with sun exposure (p = .001). Surgery combined with electrochemotherapy (ECT) yielded a survival rate 32% higher than using a surgical approach alone (HR = 0.32,p = .038, IC = 0.11–0.94). ECT, with or without surgery, had an objective response rate of 90.9%. Local lymph node and/or distant site metastasis at diagnosis, or at some point during follow‐up, occurred in 34.6% (18/52) of animals. Animals with tumours in sun exposed locations had more aggressive histopathological characteristics but had longer overall survival time. This is probably due to individualised therapeutic treatment with both surgery and ECT.
Potential determinants of low circulating glucagon‐like peptide 2 concentrations in Zambian children with non‐responsive stunting
Authors: Besa Ellen , Tembo Mizinga Jacqueline , Mulenga Chola , Mweetwa Monica , Choudhry Naheed , Chandwe Kanta , Storer Chad , Head Richard , Amadi Beatrice , Haritunians Talin , McGovern Dermot , Kwenda Geoffrey , Peiris Madusha , Kelly Paul 
Published: February 2023

AbstractNutrient sensing determines digestive and hormonal responses following nutrient ingestion. We have previously reported decreased levels of glucagon‐like peptide 2 (GLP‐2) in children with stunting. Here we demonstrate the presence of enteroendocrine cells in stunted children and explore potential pathways that may be involved in reduced circulating levels of GLP‐2. At the time of performing diagnostic endoscopies for non‐responsive stunted children, intestinal biopsies were collected for immunofluorescence staining of enteroendocrine cells and transcriptomic analysis. Circulating levels of GLP‐2 were also measured and correlated with transcriptomic data. An exploratory genome‐wide association study (GWAS) was conducted on DNA samples (n = 158) to assess genetic contribution to GLP‐2 variability. Intestinal tissue sections collected from non‐responsive stunted children stained positive for chromogranin A (88/89), alongside G‐protein‐coupled receptors G‐protein receptor 119 (75/87), free fatty acid receptor 3 (76/89) and taste 1 receptor 1 (39/45). Transcriptomic analysis found three pathways correlated with circulating GLP‐2: sugar metabolism, epithelial transport, and barrier function, which likely reflect downstream events following receptor–ligand interaction. GWAS analysis revealed potential genetic contributions to GLP‐2 half‐life and receptor binding. Enteroendocrine cell loss was not identified in stunted Zambian children as has been observed for goblet and Paneth cells. Transcriptomic analysis suggests that GLP‐2 has pleiotrophic actions on the intestinal mucosa in malnutrition, but further work is needed to dissect pathways leading to perturbations in nutrient sensing.