bluuebunny/crossref_metadata_2025_split huggingface dataset:
Next generation sequencing predicting clinical effect of immunotherapy on adult rhabdomyosarcoma patient: A case report
Authors: Sun Xiaogang , Wang Xinyu , Zhou Jun , Xu Yali , Zhang Hao , Xu Mian , Shen Jiaojiao , Shi Xiaoliang , Song Wei , Li Jun 
Published: June 2023

Rationale:
Rhabdomyosarcoma (RMS) is a rare sarcoma that rarely occurs in adults and accounts for only 1% of all adult tumors. The standard treatment for RMS is surgical resection, radiotherapy, and chemotherapy.

Patient concerns:
Adult patients often present with an aggressive course and poor prognosis.

Diagnoses:
The patient was diagnosed with RMS in September 2019 and was confirmed by hematoxylin-eosin staining and immunohistochemistry after surgical resection.

Interventions:
The patient received surgical resection in September 2019. He was admitted to another hospital after the first recurrence in November 2019. After the second routine surgical resection, the patient underwent chemotherapy, radiotherapy, and anlotinib maintenance treatment. He relapsed again in October 2020 and was admitted to our hospital. Next-generation sequencing was performed on the punctured tissue of the patient’s lung metastatic lesion, and high tumor mutational burden (TMB-H), high microsatellite instability (MSI-H), and positive programmed death-ligand 1 (PD-L1) were observed. The patient then received toripalimab and anlotinib combined therapy and was evaluated for a partial response after 2 months.

Outcomes:
This benefit has persisted for more than 17 months.

Lessons:
This is the longest progression-free survival for PD-1 inhibitors in RMS, and there is a trend of continued extension of progression-free survival in this patient. This case supports the hypothesis that positive PD-L1, TMB-H, and MSI-H could be beneficial biomarkers for immunotherapy in adult RMS.
Influence of physicians’ seniority on efficacy of silver needle therapy for low back fasciitis: A prospective, cohort study
Authors: Tian Xiaojun , Li Wei , Zhou Bin , Zhang Bing , Wang Xuan , Yin Yanwei , Yu Junmin , Wu Xing , Sun Xiuming , Meng Chao 
Published: June 2023

Background:
Physicians’ seniority has always been the focus of patients. Silver needle therapy (SNT) has been applied for more than 60 years. It is similar to moxibustion and has a good therapeutic effect on soft tissue pain. This study aimed to determine the influence of physicians’ seniority on the efficacy of SNT for patients with low back fasciitis.

Methods:
This was a prospective cohort study at the Affiliated Hospital of Qingdao University. Patients diagnosed with low back fasciitis were split into junior physician (JP) and senior physician (SP) groups (n = 30) based on the seniority of the physician. The numerical rating scale (NRS) was administered during the SNT, and operation time was recorded. The NRS, Oswestry Disability Index (ODI), and Short-Form 12 of quality of life (SF-12) scores at 1, 2, 6, and 12 months after the treatment and autonomic nervous system (ANS) activity were also observed.

Results:
Compared with the SP group, the NRS score during the SNT (5.20 ± 0.71 vs 2.53 ± 0.94) and operation time (11.7 ± 1.6 minutes vs 6.8 ± 1.1 minute) were higher in the JP group (P < .05). The NRS, ODI score, SF-12 score, and ANS activity after treatment were not significantly different between SP and JP groups. Additionally, in the multivariate linear regression analysis model, the physicians’ seniority was an independent factor affecting the NRS score during the SNT and operation time (P < .05).

Conclusion:
SNT could attenuate the pain of patients with low back fasciitis in the short and long term without severe complications. The physicians’ seniority did not influence the efficacy of SNT, but the JP group showed an increased operation time and a higher degree of pain during the operation.
A rare cause of hematochezia: colonic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALToma): A case report and literature review
Authors: Lu Chien-Hung , Kao Wei-Yu , Chang Chun-Chao , Kan Yu-An 
Published: June 2023

Rationale:
Colonic extranodal mucosa-associated lymphoid tissue lymphoma as a cause of hematochezia is rare. Here, we report a case of colonic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALToma) with presentation of freshy bloody stool and successfully treated by endoscopic mucosal resection.

Patient concerns:
This case was a 69-year-old woman with history of hypertension, reflux esophagitis, and peptic ulcer. She had several episodes of hematochezia and thus sought medical attention at the outpatient clinic.

Diagnoses:
Colonoscopy revealed a 12-mm semipedunculated lesion in the ascending colon. Histopathological examination and immunochemistry were compatible with colonic extranodal mucosa-associated lymphoid tissue lymphoma.

Interventions:
Endoscopic mucosal resection was done for tumor removal and hemoclipping was done to achieve hemostasis.

Outcomes:
The patient remained well without recurrence during 3 years of outpatient follow-up.

Lesson:
Colonic MALToma is a rare disease, and could present as hematochezia. En bloc endoscopic resection could achieve long-term remission. The prognosis of colonic MALToma is excellent with its indolent characteristics.
Recovery of severe COVID-19 complicated with cerebral infarction: Considerations on a case report
Authors: Mao Erli , Qu Zhaohui , Jin Juan , Yao Cui , Lyu Wenjun , Jiang Feng , Ding Hui , Wu Chuyan 
Published: June 2023

Rationale:
The standardization, individualization, and rationalization of intensive care and treatment for severe patients have improved. However, the combination of corona virus disease 2019 (COVID-19) and cerebral infarction presents new challenges beyond routine nursing care.

Patient concerns and diagnoses:
This paper examines the rehabilitation nursing of patients with both COVID-19 and cerebral infarction as an example. It is necessary to develop a nursing plan for COVID-19 patients and implement early rehabilitation nursing for cerebral infarction patients.

Interventions:
Timely rehabilitation nursing intervention is essential to enhance treatment outcomes and promote patient rehabilitation. After 20 days of rehabilitation nursing treatment, patients showed significant improvement in visual analogue scale score, drinking test, and upper and lower limb muscle strength.

Outcomes:
Treatment outcomes for complications, motor function, and daily activities also improved significantly.

Lessons:
Critical care and rehabilitation specialist care play a positive role in ensuring patient safety and improving their quality of life by adapting measures to local conditions and the timing of care.
Exploring the mechanism of Ginkgo biloba L. leaves in the treatment of vascular dementia based on network pharmacology, molecular docking, and molecular dynamics simulation
Authors: Pan Jienuo , Tang Jiqin , Gai Jialin , Jin Yilan , Tang Bingshun , Fan Xiaohua 
Published: June 2023

Background:

Ginkgo biloba L. leaves (GBLs) play a substantial role in the treatment of vascular dementia (VD); however, the underlying mechanisms of action are unclear.

Objective:
This study was conducted to investigate the mechanisms of action of GBLs in the treatment of VD through network pharmacology, molecular docking, and molecular dynamics simulations.

Methods:
The active ingredients and related targets of GBLs were screened using the traditional Chinese medicine systems pharmacology, Swiss Target Prediction and GeneCards databases, and the VD-related targets were screened using the OMIM, DrugBank, GeneCards, and DisGeNET databases, and the potential targets were identified using a Venn diagram. We used Cytoscape 3.8.0 software and the STRING platform to construct traditional Chinese medicine–active ingredient–potential target and protein–protein interaction networks, respectively. After gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis of potential targets using the DAVID platform, the binding affinity between key active ingredients and targets was analyzed by molecular docking, and finally, the top 3 proteins–ligand pairs with the best binding were simulated by molecular dynamics to verify the molecular docking results.

Results:
A total of 27 active ingredients of GBLs were screened and 274 potential targets involved in the treatment of VD were identified. Quercetin, luteolin, kaempferol, and ginkgolide B were the core ingredients for treatment, and AKT1, TNF, IL6, VEGFA, IL1B, TP53, CASP3, SRC, EGFR, JUN, and EGFR were the main targets of action. The main biological processes involved apoptosis, inflammatory response, cell migration, lipopolysaccharide response, hypoxia response, and aging. PI3K/Akt appeared to be a key signaling pathway for GBLs in the treatment of VD. Molecular docking displayed strong binding affinity between the active ingredients and the targets. Molecular dynamics simulation results further verified the stability of their interactions.

Conclusion subsections:
This study revealed the potential molecular mechanisms involved in the treatment of VD by GBLs using multi-ingredient, multi-target, and multi-pathway interactions, providing a theoretical basis for the clinical treatment and lead drug development of VD.
Challenges and chances coexist: A visualized analysis and bibliometric study of research on bioresorbable vascular scaffolds from 2000 to 2022
Authors: Zhang Xiaohan , Guo Zezhen , Zhu Lihong , Liu Yao , Wang Huan , Jiang Yuchen , Du Bai , Hu Yuanhui 
Published: June 2023

Background:
Bioresorbable scaffolds (BVS) provide a transient supporting force for blocked vessels and allow them to return to previous physiological characteristics. After verification with twists and turns, it has been acknowledged as an emerging revolution in percutaneous coronary intervention that expresses the current concept of intervention without placement. Through this bibliometric study, we organized the knowledge structure of bioresorbable scaffolds and attempted to predict future research hotspots in this field.

Methods:
seven thousand sixty-three articles were retrieved from the web of science core collection database from 2000 to 2022. Then, we utilize CiteSpace 6.1.R2, Biblioshiny and VOS viewer 1.6.18 to analyze the data visually.

Results:
First, according to the spatial analysis, the number of annual publications has shown an approximately increasing trend over the past 2 decades. The USA, the People’s Republic of China, and GERMANY published the most articles on bioresorbable scaffolds. Second, SERRUYS P ranked first for his most prolific work and highest cited frequency in this domain. Third, the hotspots in this field can be inferred from the keyword distribution; they were the fabrication technique based on tissue engineering; the factors to be optimized for bioresorbable scaffolds, such as mechanical property, degradation, and implantation; and the common adverse effects of bioresorbable scaffolds, such as thrombosis. Most importantly, in terms of burst detection, we could speculate that cutting-edge technology for manufacturing scaffolds represented by 3D printing constitutes the future hotspots in bioresorbable scaffold development.

Conclusion:
In the first visualized bibliometric analysis of BVS, we attempt to provide a panoramic view. By enrolling extensive literature, we review the growing trend of BVSs. Since its first introduction, it has been through periods of early prosperity, questioned safety subsequently and the resultantly advanced techniques in recent years. In future, the research should focus on utilizing novel techniques to consummate the manufacturing quality and assure the safety of BVSs.
Effects of physical activity interventions on anthropometric indicators and health indices in Chilean children and adolescents: A protocol for systematic review and/or meta-analysis
Authors: Godoy-Cumillaf Andrés , Farías-Valenzuela Claudio , Duclos-Bastías Daniel , Giakoni-Ramírez Frano , Vásquez-Gómez Jaime , Bruneau-Chávez José , Bizzozero-Peroni Bruno 
Published: June 2023

Introduction:
Physical activity interventions have been a proven effective means of preventing or treating overweight and obesity in children and adolescents. The results of these interventions in many cases are based on the determination of the effect they produce on anthropometric evaluations, which allow the calculation of health indices. However, the effects of physical activity interventions on anthropometric assessments in Chilean children and adolescents have not been systematized. The objective of this study is to provide a detailed protocol for a systematic review with meta-analysis that synthesizes the available evidence on the effect of physical activity interventions on anthropometric indicators and health indices in Chilean children and adolescents and identifies the field-based methods and health indices most used for body composition estimation.

Methods:
This protocol was performed according to the PRISMA declaration. MEDLINE (PubMed), Web of Science, Scopus, and Scielo databases will be systematically searched. Eligible studies will include randomized controlled trials (RCTs), non-RCTs and pre-post studies.

Conclusion:
This systematic review and meta-analysis protocol is designed to provide up-to-date evidence that could significantly assist public health policy makers and implementers of physical activity interventions through evidence-based guidance and recommendations.
Dorsal pancreatic agenesis: a case report
Authors: Dhakal Binaya , Pant Sujit , Choudhary Saroj , Basnet Bina , Neupane Shanta 
Published: June 2023

Introduction and importance:
The pancreas develops from a small ventral bud and a larger dorsal bud. During the rotation of the foregut, the ventral pancreas rotates toward the dorsal pancreas and joins together to form a complete pancreas with ducts. Among the various developmental congenital anomalies, dorsal pancreatic agenesis is one of the rare entities, with less than a hundred cases reported so far. It involves the absence of the dorsal bud derivatives (head, body, and tail).

Case presentation:
Herein, we present a case of a 50-year-old woman who presented to general outpatient department with a complaint of abdominal pain. The patient was diagnosed with cholelithiasis with a contrast-enhanced computed tomography finding of dorsal pancreatic agenesis on a detailed workup. However, the patient did not have any other associated anomalies or symptoms associated with dorsal pancreatic agenesis. The patient was managed for cholelithiasis with laparoscopic cholecystectomy.

Clinical discussion:
Failure in development due to aberrant embryogenesis may cause partial or complete agenesis of the dorsal pancreas. The minor papilla, the accessory pancreatic duct, the body, and the tail of the pancreas are not present in the case of complete dorsal agenesis. Most cases of dorsal pancreatic agenesis are asymptomatic and diagnosed incidentally, whereas some of the cases may present with other associated abnormalities. It is almost always diagnosed via imaging modalities.

Conclusion:
Dorsal pancreatic agenesis is a very rare congenital anomaly of the pancreas. It can be diagnosed via various imaging modalities and almost always remains a radiological diagnosis with incidental findings.
An institutional experience of hydatidosis and cysticercosis in Nepal: a retrospective chart review
Authors: Sharma Nisha , Tiwari Sansar B. , Gaire Prabin , Manandhar Usha , Bohara Sujan , Nepal Gaurav 
Published: June 2023

Background:
This study aimed to investigate the demographic characteristics, anatomical distribution, and histopathological features of hydatidosis and cysticercosis in a Nepalese population presenting to a tertiary care hospital. The study also aimed to provide a better understanding of the clinical and pathological aspects of these diseases in the local context.

Methods:
This retrospective study analyzed all cases of hydatidosis and cysticercosis reported in the Department of Pathology at Tribhuvan University Teaching Hospital between January 2013 and December 2019. Demographic, clinical, radiological, and histopathological data were collected and analyzed from hospital charts.

Results:
During the 7-year study period, the authors identified 112 cases of hydatid cysts and 26 cases of cysticercosis. The mean age of patients with hydatidosis was 33.86 years (range: 5–74 years), while the mean age of patients with cysticercosis was 25.39 years (range: 4–63 years). Females were more commonly affected with hydatidosis (68, 61.7%) than males (44, 39.3%), resulting in a male-to-female ratio of 0.6:1. In contrast, there was no significant sex difference in cysticercosis cases, with 14 (53.85%) males and 12 (46.15%) females affected. The most commonly affected site for hydatid cysts was the lung (47 cases, 42%), followed by the liver (41 cases, 36.6%). The study identified three cases of neurocysticercosis. The average diameter of hydatid cysts and cysticercosis was 8.7 cm and 1.7 cm, respectively.

Conclusion:
In conclusion, our study provides important insights into the clinical and pathological features of hydatidosis and cysticercosis in a Nepalese population. These zoonotic diseases pose a significant health burden, particularly among the poor and marginalized populations. Our findings highlight the need to integrate prevention and control measures into the healthcare system to decrease the overall burden of these diseases.
Malignant cerebral edema after cranioplasty, a rare complication: case series and literature review
Authors: Bui Manh Huy , Dong He Van , Duong Ha Dai , VAN Hanh Duc , Dong Son Van , Bui Cuong Xuan , Chu Hung Thanh 
Published: June 2023

Objective:
Cranioplasty is standard neurosurgery performed after decompressive craniectomy. Fatal malignant cerebral oedema complications associated with this procedure are rare and clinically distinct, although unpredictable. It is thought that the pressure difference from removing atmospheric pressure had a long-term effect on the brain. This combined with the negative pressure applied by intraoperative pressure drainage may impact the perfusion brain. Here, the authors report four cases of cerebral oedema after cranioplasty and review similar cases in the literature.

Case presentation:
The authors report on four cases of patients who underwent cranioplasty following decompressive craniotomy and subsequently died after surgery. Three of the patients had undergone craniotomy following trauma, while one patient had skull resorption. All four patients developed cerebral oedema immediately after surgery and exhibited significant craniofacial depression (also known as sunk flap syndrome). A negative pressure drainage system was utilized in all cases. One patient remained intubated, while the remaining three developed postoperative epilepsy and subsequently fell into a coma. Dilated and fixed pupils were observed in all patients, and computed tomography scans revealed diffuse cerebral oedema. Despite intensive resuscitation efforts and attempts at decompression, all four patients ultimately succumbed to their conditions.

Conclusion:
Fatal post-cranioplasty malignant cerebral oedema is a rare but very dangerous complication. Despite being rare, neurosurgeons should be aware that this fatal complication can occur after cranioplasty.
Using Two Statewide Medical Operations Coordination Centers to Load Balance in Pediatric Hospitals During a Severe Respiratory Surge in the United States
Authors: Mitchell Steven H. , Merkel Matthias J. , Eriksson Carl O. , Sakata Vicki L. , King Mary A. 
Published: June 2023

OBJECTIVES:
Report on the use of two statewide Medical Operations Coordination Centers (MOCCs) to manage a rapid surge in pediatric acute and critical care patient needs.

DESIGN:
Brief report.

SETTING:
The states of Washington and Oregon during the pediatric respiratory surge in November 2022/December 2022 which overwhelmed existing pediatric acute and critical care hospital capacity.

PATIENTS:
Pediatric patients requiring hospitalization in Washington and Oregon.

INTERVENTIONS:
Adaptations to the use of two existing statewide MOCCs to provide pediatric patient load balancing through surveillance, modifications of existing referral agreements, coordinated expansion of resources, activation of regional crisis standards of care, and integration of pediatric critical care physicians from Harborview Medical Center as subject matter experts (SMEs).

MEASUREMENTS AND MAIN RESULTS:
The Washington and Oregon MOCCs managed 183 pediatric requests from hospitals unable to transfer pediatric patients between November 1, 2022, and December 14, 2022. Sixteen percent of requests were for children younger than 3 months and 37% were for children between 3 months and 1 year; most had acute viral respiratory disease. Requests for children older than 13 years old were primarily intentional drug ingestions. Fifty-eight percent were for critically ill children and 17% originated from critical access hospitals. Washington’s SMEs were utilized in nearly a quarter of cases with the disposition changing in 38% of these.

CONCLUSIONS:
Washington and Oregon statewide MOCCs have leveraged centralized coordination to effectively load balance a surge in pediatric patients which has overwhelmed existing pediatric hospital resources. Centralized coordination and surveillance informed pediatric hospitals and policy makers of unmet clinical needs and facilitated rapid expansion of clinical capacity and modifications to referral processes. Integration of pediatric SMEs enabled efficient triage of these resources. MOCCs provide an adaptable centralized resource for addressing surge and have been effective in managing overwhelmed pediatric hospital resources in Washington and Oregon.
Additional boosting to the RV144 vaccine regimen increased Fc-mediated effector functions magnitude but not durability
Authors: Shubin Zhanna , Stanfield-Oakley Sherry , Puangkaew Jiraporn , Pitisutthithum Punnee , Nitayaphan Sorachai , Gurunathan Sanjay , Sinangil Faruk , Chariyalertsak Suwat , Phanuphak Nittaya , Ake Julie A. , O’connell Robert J. , Vasan Sandhya , Akapirat Siriwat , Eller Michael A. , Ferrari Guido , Paquin-Proulx Dominic 
Published: June 2023

Objective(s):
The RV144 vaccine trial resulted in a decreased risk of HIV acquisition that was associated with a non-neutralizing antibody response. The objective of this study was to determine the impact of an additional boost to the RV144 vaccine regimen on antibody effector function and durability.

Design:
RV306 was a randomized, double-blind late boosting of the RV144 prime-boost regimen in HIV-uninfected Thai Adults (NCT01931358). This analysis included study participants who received the RV144 vaccine regimen and received no additional boost (Group 1) or were boosted with ALVAC-HIV and AIDSVAX Group 2) or only AIDSVAX alone (Group 3) 24 weeks after completing the RV144 series.

Methods:
Plasma samples from RV306 study participants were used to measure antibody dependent cellular phagocytosis (ADCP), antibody dependent neutrophil phagocytosis (ADNP), antibody dependent complement deposition (ADCD), antibody dependent cellular cytotoxicity (ADCC), trogocystosis, and gp120-specifc IgG subclasses.

Results:
Additional boosting increased the magnitude of all Fc mediated effector functions two weeks following the additional boost compared to two weeks after completing the RV144 regimen. However, only trogocytosis remained higher 24 to 26 weeks after the last vaccination for the study participants receiving an additional boost compared to those that did not receive an additional boost. The additional boost increased IgG1 and IgG4 but decreased IgG3 gp-120 specific antibodies compared to two weeks after completing the RV144 regimen.

Conclusions:
Additional boosting of RV144 improved the magnitude but not the durability of some Fc mediated effector functions that were associated with vaccine efficacy, with trogocytosis being the most durable.