bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical antipsychotics olanzapine and clozapine increase bone loss in female rats with experimental periodontitis
Authors: Soares Mariana Alves , Costa André Luiz A. , Silva Natália L. C. , Martins Aline França , Matias Daiane Oliveira , Araujo Olga M. O. , Lopes Ricardo Tadeu , Takiya Christina Maeda , Miranda Ana Luisa P. , Miranda‐Alves Leandro , Tributino Jorge L. M. 
Published: December 2022

AbstractBackground and ObjectivesPeriodontitis is a highly prevalent disease in psychiatric patients, including those undergoing symptomatic treatment with second‐generation antipsychotics. Some of these drugs, such as clozapine (CLO) and olanzapine (OLA), have prominent metabolic effects such as weight gain, hyperglycemia, and dyslipidemia, which are risk factors for periodontitis. In addition to the metabolic effects, there are reports of changes in salivary flow, gingival bleeding, and caries. In this context, we aimed to evaluate if the metabolic effects of OLA and CLO alter periodontal parameters in an animal model of periodontitis without the environmental and psychosocial biases inherent to human diseases.MethodsIn the first set of experiments, male and female adult Wistar rats received oral administration of CLO, OLA, or vehicle for 45 days. They were evaluated for body mass composition and weight gain, blood glucose parameters (fasting and glucose tolerance and insulin resistance tests), and lipid profile (HDL, total cholesterol, and triglycerides). In a second set of experiments, the same measurements were performed in female rats exposed to the antipsychotics for 45 days and ligature‐induced periodontitis on the 30th day of treatment. Macroscopic measurements of exposed roots, microtomography in the furcation region of the first molar, and histological evaluation of the region between the first and second molars were evaluated to assess bone loss. Additionally, gingival measurements of myeloperoxidase activity and pro‐inflammatory cytokine TNF‐α were made.ResultsOnly females exposed to OLA had more significant weight gain than controls. They also exhibited differences in glucose metabolism. Ligature‐induced periodontitis produced intense bone retraction without changing the density of the remaining structures. The bone loss was even higher in rats with periodontitis treated with OLA or CLO and was accompanied by a local increase in TNF‐α caused by CLO. These animals, however, did not exhibit the same metabolic impairments observed for animals without periodontitis.ConclusionThe use of clozapine and olanzapine may be a risk factor for periodontal disease, independent of systemic metabolic alterations.
Practical Aspects in the Study of Biological Photosensitization Including Reaction Mechanisms and Product Analyses: A Do's and Don'ts Guide†
Authors: Baptista Maurício S. , Cadet Jean , Greer Alexander , Thomas Andrés H. 
Published: December 2022

AbstractThe interaction of light with natural matter leads to a plethora of photosensitized reactions. These reactions cause the degradation of biomolecules, such as DNA, lipids, proteins, being therefore detrimental to the living organisms, or they can also be beneficial by allowing the treatment of several diseases by photomedicine. Based on the molecular mechanistic understanding of the photosensitization reactions, we propose to classify them in four processes: oxygen‐dependent (type I and type II processes) and oxygen‐independent [triplet‐triplet energy transfer (TTET) and photoadduct formation]. In here, these processes are discussed by considering a wide variety of approaches including time‐resolved and steady‐state techniques, together with solvent, quencher, and scavenger effects. The main aim of this survey is to provide a description of general techniques and approaches that can be used to investigate photosensitization reactions of biomolecules together with basic recommendations on good practices. Illustration of the suitability of these approaches is provided by the measurement of key biomarkers of singlet oxygen and one‐electron oxidation reactions in both isolated and cellular DNA. Our work is an educational review that is mostly addressed to students and beginners.
What drives economic growth forecast revisions?
Authors: Hadzi‐Vaskov Metodij , Ricci Luca Antonio , Werner Alejandro Mariano , Zamarripa Rene 
Published: December 2022

AbstractThis article investigates how the IMF WEO growth forecast revisions behave across different horizons and country groups. Our main findings suggest that (i) growth revisions in horizons closer to the actual are generally larger, more volatile, and more negative; (ii) on average, growth revisions are in the right direction, becoming progressively more responsive to forecast errors as horizons get closer to the actual year; (iii) growth revisions in systemic economies are relevant for growth revisions in all country groups; (iv) across vintages, revisions for a given time horizon are not autocorrelated; within vintages, they tend to be positively associated, suggesting a persistent perception of short‐term shocks; and (v) professional growth revisions are highly correlated.
Better policy interventions through intersectionality
Authors: Cole Elizabeth R. , Duncan Lauren E. 
Published: December 2022

AbstractDeployment of intersectionality frameworks in policy design and implementation is a way to ensure that the means and goals of interventions are congruent with target populations’ understanding of their circumstances, their desired outcomes, and their empowerment. In this paper, we examine the ways concepts from psychology have been used to inform interventions and policies, and we use an intersectional lens to suggest improvements to these interventions to be more inclusive in their impact. We review three social policy interventions that were developed based on social psychological research: (1) sexual assault prevention programs based on bystander interventions; (2) so‐called “wise schooling” programs, intended to ameliorate gaps in academic achievement stemming from stereotype threat; and (3) programs aiming to foster pro‐environmental behavior, specifically, recyling. Following Cole's (2009) recommendations for using intersectionality in research in psychology together with the guiding principles that define Intersectionality‐Based Policy Analysis (Hankivsky et al., 2014), we interrogate how the psychological research that provides the foundation for these policies informs them at different points in the policy cycle and suggest alternatives designed to more equitably address these problems. Our analysis shows that these problems demand a multi‐level analysis that recognizes intersecting identities.
Suicide attempts and mental health diagnoses in combat‐injured service members: A retrospective cohort study
Authors: Walker Lauren E. , Poltavskiy Eduard , Howard Jeffrey T. , Janak Jud C. , Watrous Jessica , Alcover Karl , Pettey Warren B. P. , Ambardar Shiva , Meyer Eric , Gundlapalli Adi V. , Stewart Ian J. 
Published: December 2022

AbstractIntroductionExaminations of risk factors for suicide attempt in United States service members at high risk of mental health diagnoses, such as those with combat injuries, are essential to guiding prevention and intervention efforts.MethodsRetrospective cohort study of 8727 combat‐injured patients matched to deployed, non‐injured patients utilizing Department of Defense and Veterans Affairs administrative records.ResultsCombat injury was positively associated with suicide attempt in the univariate model (HR = 1.75, 95% CI 1.5–2.1), but lost significance after adjustment for mental health diagnoses. Utilizing Latent Transition Analysis in the combat‐injured group, we identified five mental/behavioral health profiles: (1) Few mental health diagnoses, (2) PTSD and depressive disorders, (3) Adjustment disorder, (4) Multiple mental health comorbidities, and (5) Multiple mental health comorbidities with alcohol use disorder (AUD). Multiple mental health comorbidities with AUD had the highest suicide attempt rate throughout the study and more than four times that of Multiple mental health comorbidities in the first study year (23.4 vs. 5.1 per 1000 person years, respectively).ConclusionFindings indicate that (1) combat injury's impact on suicide attempt is attenuated by mental health and (2) AUD with multiple mental health comorbidities confers heightened suicide attempt risk in combat‐injured service members.
Interspecific introgression patterns reveal the origins of worldwide cultivated bananas in New Guinea
Authors: Martin Guillaume , Cottin Aurélien , Baurens Franc‐Christophe , Labadie Karine , Hervouet Catherine , Salmon Frédéric , Paulo‐de‐la‐Reberdiere Nilda , Van den Houwe Ines , Sardos Julie , Aury Jean‐Marc , D'Hont Angélique , Yahiaoui Nabila 
Published: December 2022

SUMMARYHybridizations betweenMusaspecies and subspecies, enabled by their transport via human migration, were proposed to have played an important role in banana domestication. We exploited sequencing data of 226Musaceaeaccessions, including wild and cultivated accessions, to characterize the inter(sub)specific hybridization pattern that gave rise to cultivated bananas. We identified 11 genetic pools that contributed to cultivars, including two contributors of unknown origin. Informative alleles for each of these genetic pools were pinpointed and used to obtain genome ancestry mosaics of accessions. Diploid and triploid cultivars had genome mosaics involving three up to possibly seven contributors. The simplest mosaics were found for some diploid cultivars from New Guinea, combining three contributors, i.e.,banksiiandzebrinarepresentingMusa acuminatasubspecies and, more unexpectedly, the New Guinean speciesMusa schizocarpa. Breakpoints ofM. schizocarpaintrogressions were found to be conserved between New Guinea cultivars and the other analyzed diploid and triploid cultivars. This suggests that plants bearing theseM. schizocarpaintrogressions were transported from New Guinea and gave rise to currently cultivated bananas. Many cultivars showed contrasted mosaics with predominant ancestry from their geographical origin across Southeast Asia to New Guinea. This revealed that further diversification occurred in different Southeast Asian regions through hybridization with otherMusa(sub)species, including two unknown ancestors that we propose to beM. acuminatassp.halabanensisand a yet to be characterizedM. acuminatasubspecies. These results highlighted a dynamic crop formation process that was initiated in New Guinea, with subsequent diversification throughout Southeast Asia.
The Miyaoka–Yau inequality on smooth minimal models
Authors: Liu Wanxing 
Published: December 2022

AbstractIn this short note, we offer an observation that the Miyaoka–Yau inequality holds for any compact Kähler manifold with nef canonical bundle, that is, a smooth minimal model. It follows directly from the existence of cscK metrics in a neighborhood of the canonical class which was confirmed both by the work of Dyrefelt and Song using different approaches.
Lipid phosphate phosphatase 3 maintains NO‐mediated flow‐mediated dilatation in human adipose resistance arterioles
Authors: Chabowski Dawid S. , Hughes William E. , Hockenberry Joseph C. , LoGiudice John , Beyer Andreas M. , Gutterman David D. 
Published: December 2022

AbstractMicrovascular dysfunction predicts adverse cardiovascular events despite absence of large vessel disease. A shift in the mediator of flow‐mediated dilatation (FMD) from nitric oxide (NO) to mitochondrial‐derived hydrogen peroxide (H2O2) occurs in arterioles from patients with coronary artery disease (CAD). The underlying mechanisms governing this shift are not completely defined. Lipid phosphate phosphatase 3 (LPP3) is a transmembrane protein that dephosphorylates lysophosphatidic acid, a bioactive lipid, causing a receptor‐mediated increase in reactive oxygen species. A single nucleotide loss‐of‐function polymorphism in the gene coding for LPP3 (rs17114036) is associated with elevated risk for CAD, independent of traditional risk factors. LPP3 is suppressed by miR‐92a, which is elevated in the circulation of patients with CAD. Repression of LPP3 increases vascular inflammation and atherosclerosis in animal models. We investigated the role of LPP3 and miR‐92a as a mechanism for microvascular dysfunction in CAD. We hypothesized that modulation of LPP3 is critically involved in the disease‐associated shift in mediator of FMD. LPP3 protein expression was reduced in left ventricle tissue from CAD relative to non‐CAD patients (P = 0.004), with mRNA expression unchanged (P = 0.96). Reducing LPP3 expression (non‐CAD) caused a shift from NO to H2O2 (% maximal dilatation: Control 78.1 ± 11.4% vs. Peg‐Cat 30.0 ± 11.2%; P < 0.0001). miR‐92a is elevated in CAD arterioles (fold change: 1.9 ± 0.01 P = 0.04), while inhibition of miR‐92a restored NO‐mediated FMD (CAD), and enhancing miR‐92a expression (non‐CAD) elicited H2O2‐mediated dilatation (P < 0.0001). Our data suggests LPP3 is crucial in the disease‐associated switch in the mediator of FMD.
imageKey points
Lipid phosphate phosphatase 3 (LPP3) expression is reduced in heart tissue patients with coronary artery disease (CAD).
Loss of LPP3 in CAD is associated with an increase in the LPP3 inhibitor, miR‐92a.
Inhibition of LPP3 in the microvasculature of healthy patients mimics the CAD flow‐mediated dilatation (FMD) phenotype.
Inhibition of miR‐92a restores nitric oxide‐mediated FMD in the microvasculature of CAD patients.
Machine Learning and Real-World Data to Predict Lung Cancer Risk in Routine Care
Authors: Chandran Urmila , Reps Jenna , Yang Robert , Vachani Anil , Maldonado Fabien , Kalsekar Iftekhar 
Published: December 2022

AbstractBackground:This study used machine learning to develop a 3-year lung cancer risk prediction model with large real-world data in a mostly younger population.Methods:Over 4.7 million individuals, aged 45 to 65 years with no history of any cancer or lung cancer screening, diagnostic, or treatment procedures, with an outpatient visit in 2013 were identified in Optum's de-identified Electronic Health Record (EHR) dataset. A least absolute shrinkage and selection operator model was fit using all available data in the 365 days prior. Temporal validation was assessed with recent data. External validation was assessed with data from Mercy Health Systems EHR and Optum's de-identified Clinformatics Data Mart Database. Racial inequities in model discrimination were assessed with xAUCs.Results:The model AUC was 0.76. Top predictors included age, smoking, race, ethnicity, and diagnosis of chronic obstructive pulmonary disease. The model identified a high-risk group with lung cancer incidence 9 times the average cohort incidence, representing 10% of patients with lung cancer. Model performed well temporally and externally, while performance was reduced for Asians and Hispanics.Conclusions:A high-dimensional model trained using big data identified a subset of patients with high lung cancer risk. The model demonstrated transportability to EHR and claims data, while underscoring the need to assess racial disparities when using machine learning methods.Impact:This internally and externally validated real-world data-based lung cancer prediction model is available on an open-source platform for broad sharing and application. Model integration into an EHR system could minimize physician burden by automating identification of high-risk patients.
Flavonifractor plautii
Protects Against Elevated Arterial Stiffness
Authors: Luo Shiyun , Zhao Yawen , Zhu Shanshan , Liu Ludi , Cheng Ken , Ye Bingqi , Han Yueyuan , Fan Jiahua , Xia Min 
Published: December 2022

Background:
Dysbiosis of gut microbiota plays a pivotal role in vascular dysfunction and microbial diversity was reported to be inversely correlated with arterial stiffness. However, the causal role of gut microbiota in the progression of arterial stiffness and the specific species along with the molecular mechanisms underlying this change remain largely unknown.

Methods:

Participants with elevated arterial stiffness and normal controls free of medication were matched for age and sex. The microbial composition and metabolic capacities between the 2 groups were compared with the integration of metagenomics and metabolomics. Subsequently, Ang II (angiotensin II)-induced and humanized mouse model were employed to evaluate the protective effect of
Flavonifractor plautii
(
F plautii
) and its main effector cis-aconitic acid.

Results:

Human fecal metagenomic sequencing revealed a significantly high abundance and centrality of
F plautii
in normal controls, which was absent in the microbial community of subjects with elevated arterial stiffness. Moreover, blood pressure only mediated part of the effect of
F plautii
on lower arterial stiffness. The microbiome of normal controls exhibited an enhanced capacity for glycolysis and polysaccharide degradation, whereas, those of subjects with increased arterial stiffness were characterized by increased biosynthesis of fatty acids and aromatic amino acids. Integrative analysis with metabolomics profiling further suggested that increased cis-aconitic acid served as the main effector for the protective effect of
F plautii
against arterial stiffness. Replenishment with
F plautii
and cis-aconitic acid improved elastic fiber network and reversed increased pulse wave velocity through the suppression of MMP-2 (matrix metalloproteinase-2) and inhibition of MCP-1 (monocyte chemoattractant protein-1) and NF-κB (nuclear factor kappa-B) activation in both Ang II-induced and humanized model of arterial stiffness.

Conclusions:

Our translational study identifies a novel link between
F plautii
and arterial function and raises the possibility of sustaining vascular health by targeting gut microbiota.
Flow Diverter Performance for the Treatment of Intracranial Aneurysms: An International Multicenter Comparative Study
Authors: Vivanco‐Suarez Juan , Flores Juan E. Basilio , Rodriguez‐Calienes Aaron , Miranda Juan Carlos , Foa Gustavo , Altschul David , Aguilar‐Melgar Joel A. , Dajles Andres , Galecio‐Castillo Milagros , Zevallos Cynthia B. , Farooqui Mudassir , Puri Ajit S. , Baca Henry Pacheco‐Fernandez , Ortega‐Gutierrez Santiago 
Published: December 2022

BackgroundCurrent evidence comparing flow diverters (FDs) for the treatment of intracranial aneurysms is limited to single‐arm head‐to‐head retrospective and prospective studies. Herein, we aimed to compare the efficacy and safety of four FDs for the treatment of intracranial aneurysms.MethodsWe performed a retrospective, multicenter international cohort study of adult patients treated with FDs (Pipeline embolization device, Surpass Streamline, Flow Redirection Endoluminal Device, and Silk) for intracranial aneurysms between 2015 and 2021. Efficacy was determined by aneurysm occlusion at final follow‐up. Safety was determined by ischemic/hemorrhagic events and mortality. Secondary safety was assessed by technical complications. A mixed‐effect multivariable ordinal and logistic regression were performed to evaluate variables that predicted the outcomes of interest.ResultsWe included 235 patients with 274 aneurysms. Treatment was performed with either the Pipeline embolization device (92), Surpass Streamline (56), Flow Redirection Endoluminal Device (47), and Silk (40). Median age was 57 (47–65) years. Most patients were asymptomatic (76%), and 8% had previous rupture. Most aneurysms were saccular (85%) and anterior (94%). The Pipeline embolization device subgroup had the largest aneurysms (6 mm,P=0.005). Median follow‐up time was 9 (6–14) months. Final overall complete occlusion was 72% without significant differences between FDs (P=0.5). Total ischemic (5%) and hemorrhagic (3%) events were also similar (P=0.1 andP=0.06). One patient expired (0.4%,P=0.6). In multivariable analysis, device diameter predicted aneurysm persistence and ≥50% in‐stent stenosis predicted ischemic/hemorrhagic complications.ConclusionsOur findings comparing 4commonly used FDs in a heterogeneous population with mainly small‐sized aneurysms confirmed a similar safety and efficacy profile between devices.
Bolzanos Konzeption bloß möglicher Gegenstände
Authors: Beyer Christian 
Published: December 2022

Abstract
In Section 1, the author argues that Bolzano does not have a Meinongian view of merely possible objects, not even in the context of his theory of intentionality. In section 2, it is argued that Williamson’s necessitist conception, according to which there is a merely possible golden mountain, was not anticipated by Bolzano. An eternalist reconstruction is rejected as well. The argument takes recourse to Bolzano’s semantics of temporal statements, which also underlies his argument for the eternity of substances and makes it plausible to assume that Bolzano had a perdurantist view, according to which there are merely possible objects just in case there are actual objects whose generation is to be metaphysically explained, in terms of grounding, by recourse to a merely possible object’s being replaced by an actual object. Furthermore, it is argued that merely possible objects à la Bolzano are not substances, in his narrow sense of the term, and that his case for such objects in connection with his view of generation is less than convincing. However, section 3 argues that Bolzano’s conception combines with his view of substance to yield an interesting perdurantist conception of personal identity.
Acceptance and Managerial Doxastic Agency
Authors: Buckareff Andrei A. 
Published: December 2022

Abstract
Managerial doxastic agency is one species of indirect doxastic agency. In this article, the author builds on some earlier work and sketches an account of managerial doxastic agency. In particular, he argues that fairly robust doxastic agency can be exercised by performing metamental actions of non-doxastically accepting propositions as true as part of a general strategy involving various means of mental control. That the sort of control counts as a form of internal control and, hence, as a form of genuine doxastic agency is defended against an objection.
The Causal Role of Consciousness in a Physical World
Authors: Pereira Roberto Horácio de Sá 
Published: December 2022

Abstract
According to Papineau’s qualitative view, experiences instantiate both representational and phenomenal properties. The instantiation of phenomenal properties is people undergoing the relevant experience. In contrast, the instantiation of representational properties relies on changing relationships between the person and the environment in which the person is embedded. The upshot is that phenomenal and representational properties are only contingently related: phenomenal properties are neither identical to, nor supervene on, representational properties. In this article, the author gives a detailed criticism of Papineau’s qualitative view. Papineau’s qualitative view left unexplained the relevant causal role of consciousness in accounting for actions—assuming that a mental state only becomes conscious when it is poised to make a direct difference to what the subject believes and later remembers, how the subject reasons, what decisions the subject makes, and what rational actions the subject performs. The author argues that the same reasons that support Papineau’s complaint that it is hard to see how distal particulars and properties make their way into the realm of consciousness—namely some traditional arguments against representationalism—also show that it is hard to see how phenomenal consciousness makes its way back into the outside world in explaining the rational control of actions.