bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of pulse pressure and CVD Incidence rate: a cohort study of a Chinese population
Authors: Liu Sitong , Yu Jiazhou , Wu Li , Wang Lu , Liu Chengguo , Yu Senhai , Zhang Xuhui 
Published: September 2023

Abstract

Background
Pulse blood pressure was significantly associated with cardiovascular mortality in middle-aged and elderly populations, but less evidence was known for the incidence of cardiovascular diseases.
Objective
The aim of this stusy was to assess the association of pulse pressure (PP) with the incident risks of cardiovascular disease in all populations,and to further evaluate relationships of pulse pressure and blood pressure, jointly, with the incidence of cardiovascular diseases.
Method
A total of 13,489 participants from the Zhejiang Metabolic Syndrome cohort was recruited. Pulse pressure was defined as the difference between the systolic blood pressure (SBP) and diastolic blood pressure (DBP), and participant pulse pressure levels were categorized into two groups : normal PP(<60 mmHg) and high PP (≥ 60 mmHg). Cox proportional hazards models was performed to estimate the hazard ratio (HR) and its 95% CI for the incidence of CVD, adjusted for the potential confounding factors.
Results
After a median of follow-up of 10.03 years, 1466 CVD events (10.9%) were observed in the cohort. The HRs of CVD were significantly positively correlated with PP. After adjusting for age, sex, smoking, drinking, BMI, HR, TG, LDL-C, FPG, Lipid-lowering drugs, Hypoglycemic agent and baseline hypertension with a multiple Cox regression model, subjects with PP ≥ 60mmHg group showed the higher risk of CVD, with a HR of 1.220 (95% CI 1.084 to 1.373).
Conclusion
PP ≥ 60 mmHg was significantly associated with an increased risk of CVD in all populations. Hypertension subjects with pulse pressure over 60mmHgshould be given more attention in the prevention of CVD and control of pulse pressure, especially in women. Further studies are needed to corroborate these findings.
Recent and Projected Trends in Oral Tongue Cancer in the United States: A Demographic Shift in Case Burden as Early Onset Increases Among Females Subside
Authors: Burus Todd , Damgacioglu Haluk , Huang Bin , Christian W. Jay , Hull Pamela C. , Ellis Amanda R. , Arnold Susanne M. , Deshmukh Ashish A. , Kuhs Krystle A. Lang 
Published: September 2023

Abstract
Background
Oral tongue cancer (OTC) incidence has increased rapidly among young (< 50 years) non-Hispanic White (NHW) individuals in the United States (U.S.) over the last two decades; however, it is unknown if age-associated trajectories have persisted. Furthermore, incidence trends for all 50 U.S. states and the District of Columbia have never been investigated.
Materials and methods
Using U.S. Cancer Statistics data, we investigated incidence trends from 2001–2019, overall and according to age, sex, race/ethnicity, and state of residence. We used age-period-cohort analysis to explore temporal patterns among birth cohorts and to project future trends and case counts.
Results
OTC incidence increased across all age, sex, and racial/ethnic groups, with marked increases observed among the NHWs (2.9%/year; 95%CI, 2.2%-3.7%). Incidence among NHWs increased in most U.S. states, particularly in the Southeast. Increases were significantly greater among NHW females compared to males (3.6%/year vs 2.6%/year; P = 0.022). Increases among females aged 50–59 years were most notable and significantly outpaced increases among younger females (4.8%/year [95% CI, 4.1%-5.4%] vs. 3.3%/year [95% CI, 2.7%-3.8%]; P < .001). While both NHW male and female birth cohorts from 1925 to 1980 saw sustained increases, rates stabilized among females born after 1980. Should trends continue, the burden of new OTC cases among NHWs in the U.S. is projected to shift to older individuals (33.1% versus 49.3% aged ≥ 70) and females (86% case increase versus 62% among males).
Conclusion
The period of rapidly increasing OTC incidence among younger NHW females in the U.S. is tempering and giving way to greater increases among older females, suggesting that a birth cohort effect may have influenced previously observed trends. Recent increases among NHWs aged ≥ 50 of both sexes have matched or outpaced younger age groups. Continuing increases among older individuals, particularly females, will lead to a shift in the OTC patient profile over time.
Self-Regulation training improves stress resilience in Elite Pre-Pubescent Female Gymnasts
Authors: Proietti Giorgia , Borozan Milos , Chaigneau Amine , Cannito Loreta , Anzani Stefano , Palumbo Riccardo , Thouvarecq Regis , Iodice Pierpaolo 
Published: September 2023

Abstract

The importance of managing stress load in young female athletes, particularly those at the highest level in sports such as gymnastics, has gained significant attention in recent times. Effective stress management strategies can help these athletes perform better, reduce the risk of injury and improve their overall well-being. The aim of the current work is to investigate the effect of training self-regulation ability through biofeedback on pre-pubescent female elite gymnasts’ stress management. 8 elite young female athletes from a top-flight French national league club took part in the study. We implemented a within-subject, cross-over design; during the experimental condition athletes involved in biofeedback training in rest and stress scenarios, while in the control condition the participants watched motivational videos. Our results show that biofeedback training of elite athletes increased self-regulatory ability and psychological resilience under stressful conditions and it seemingly decreased sensitivity to gymnastics-specific stress. The main result of this study is to have demonstrated that individual’s ability to self‐regulate stress‐related psychophysiological phenomena is trainable.
Comparative Quantum-Classical Dynamics of
Natural and Synthetic Molecular Rotors Shows How Vibrational Synchronization Modulates Quantum Efficiency
Authors: Olivucci Massimo , Blanco-Gonzalez Alejandro , Manathunga Madushanka , Yang Xuchun 
Published: September 2023

Abstract

We use quantum-classical trajectories to investigate the origin of the different photoisomerization quantum efficiency observed in the dim-light visual pigment Rhodopsin and in the light-driven biomimetic molecular rotor para-methoxy N-methyl indanylidene-pyrrolinium (MeO-NAIP) in methanol. The results reveal that effective light-energy conversion requires, in general, an auxiliary molecular vibration (called promoter) that does not correspond to the rotary motion but synchronizes with it at specific times. They also reveal that Nature has designed Rhodopsin to exploit two mechanisms working in a vibrationally coherent regime. The first uses a wag promoter to ensure that ca. 75% of the absorbed photons lead to unidirectional rotations. The second mechanism ensures that the same process is fast enough to avoid directional randomization. It is found that MeO-NAIP in methanol is incapable of exploiting the above mechanisms resulting into a 50% quantum efficiency loss. However, when the solvent is removed, MeO-NAIP rotation is predicted to synchronize with a ring-inversion promoter leading to a 30% increase in quantum efficiency and, therefore, biomimetic behavior.
A Systematic Review on NSAID and Tanezumab efficacy in Chronic Lower Back Pain
Authors: Kasireddy Smaran , Sahu Sweta , Ishfaq Lyluma , Rahmath Berjis , Doddareddy Navya Pillikunte , Moondra Mudit , Parmar Mihirkumar P. , Venugopal Vishal 
Published: September 2023

Abstract
Chronic back pain is an ailment that impacts people of all ages and lasts longer than 12 weeks. 7.41% of all Years Lost to Disability (YLD) are associated with low back pain, which makes it the pathology responsible for the most YLD, surpassing other chronic conditions such as Diabetes and Depression. Despite the prevalence of drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs), painkillers, and biologics, the types of drugs administered to individuals differ greatly. We collected data from the PubMed database of the PubMed database, National Library of Medicine (NIH), and Google Scholar. Randomized controlled trials (RCTs) that explicitly evaluate the effectiveness of various NSAIDs in adult patients with chronic back pain were selected for this study. After an exhaustive search and examination of numerous publications, only 8 articles met the inclusion criteria. In recent studies that included NSAIDs, they were among the most frequently prescribed medications for the treatment of chronic low back pain. In comparison to placebo, selective COX-II inhibitors such as celecoxib and etoricoxib were found to be efficacious, while valdecoxib was associated with serious side effects. In addition to reducing back pain, COX-II inhibitors with a preference for COX-II, such as aceclofenac and diclofenac, were associated with gastrointestinal side effects. Despite the risk of joint degeneration and accelerated osteoarthritis, intravenous tanezumab may be superior to naproxen and placebo in treating chronic low back pain.
Progression of an Artificial Intelligence Chatbot (ChatGPT) for Pediatric Cardiology Educational Knowledge Assessment: Considerable Gains in a Short Time
Authors: Gritti Michael N. , AlTurki Hussain , Farid Pedrom , Morgan Conall T. 
Published: September 2023

Abstract
Introduction
Artificial intelligence chatbots, like ChatGPT, have become powerful tools that are disrupting how humans interact with technology. The potential uses within medicine are vast. In medical education, these chatbots have shown improvements, in a short time span, in generalized medical examinations. We evaluated the overall performance and improvement between ChatGPT 3.5 and 4.0 in a test of pediatric cardiology knowledge.
Methods
ChatGPT 3.5 and ChatGPT 4.0 were used to answer text based multiple choice questions derived from a Pediatric Cardiology Board Review textbook. Each chatbot, was given an 88 question test, subcategorized into 11 topics. We excluded questions with modalities other than text (sound clips or images). Statistical analysis was done using an unpaired two-tailed t-test.
Results
Of the same 88 questions, ChatGPT 4.0 answered 66% of the questions correctly (n=58/88) which was significantly greater (p<0.0001) than ChatGPT 3.5, which only answered 38% (33/88). The ChatGPT 4.0 version also did better on each subspeciality topic as compared to ChatGPT 3.5.
Conclusion
While acknowledging that ChatGPT does not yet offer subspecialty level knowledge in pediatric cardiology, the performance in pediatric cardiology educational assessments showed a considerable improvement in a short period of time between ChatGPT 3.5 to 4.0.
Analysis of TPH-2 single nucleotide polymorphisms and depressive symptoms in a Mexican cohort of HIV-1 patients treated with efavirenz- and atazanavir
Authors: Rojas-Osornio Sandra , Guerra-Castillo Francisco , Mata-Marín Antonio , Ortiz-Maganda Mónica , Bekker-Méndez Carolina , Paredes-Cervantes Vladimir , Aguirre-Alvarado Charmina , Crespo-Ramírez Minerva , Mora Miguel Pérez , Fuxe Kjell , Pérez-Sanchez Gilberto , Molina-López José , Mercado-Mendez Aurora , Borroto-Escuela Dasiel , Tesoro.Cruz Emiliano 
Published: September 2023

Abstract
Background
Depressive disorders have been associated with TPH2 gene polymorphisms. Additionally, HIV-1 antiretroviral drugs (ART) such as efavirenz (EFV) have been reported to cause neuropsychiatric adverse effects.
Objective
This study aimed to determine the genotypes and allelic frequencies of TPH2 SNPs (rs120074175, rs1386493, rs4570625, and rs7305115) in a Mexican cohort of ART-naive patients, and healthy volunteers as control, and assess the severity of their depressive symptoms using the Beck Depression Inventory (BDI).
Methods
In a prospective study conducted from January 2017 to December 2018, eigthy-one HIV-1-positive ART-naive patients were recruited from the Infectious Disease Hospital, National Medical Center “La Raza”, Mexico City; 39 were treated with EFV, and 42 treated with atazanavir (ATV). Additionally, 59 healthy subjects were included as controls. Blood samples were collected and genomic DNA obtained from peripheral blood polymorphonuclear cells. All DNA samples were subjected to qPCR using TaqMan probes for the TPH2 SNPs. Additionally, all subjects were evaluated using the BDI.
Results
The frequencies and distributions of alleles among the SNPs studied showed that the genotype frequencies resulted in Hardy-Weinberg equilibrium (HWE) for all SNPs evaluated, except for the rs120074175 in the people living with HIV (PLWH), and controls with the wild-type allele (GG genotype, 100%). Three of the four analyzed SNPs did not show statistically significant differences in the distribution of the rs1386493, rs4570625 and rs7305115 alleles between patients and controls. A total of 64.1% of PLWH, who were treated with EFV had depression according to the initial BDI score, and after four weeks, 90.4% of them had severe depression. Among patients treated with ATV, 73.8% had severe depression at the baseline and, at 4 weeks, 87.5% had severe depression. The increase in depressive symptoms was more evident in patients treated with EFV (EFV X2: 19.085; df: 1; p < 0.0001; ATV X2: 5.383; df: 1; p = 0.0203).
Conclusion
In this study, we showed that 69.13% of patients with HIV diagnosis have severe depression from started. The severity of depressive symptoms was higher in the group of patients treated with EFV after four weeks of treatment. It will be important to consider a psychiatric monitoring of each patient to contain adverse effects and/or provide timely antidepressant treatment.
Evaluation of settlement sensitivity and graded zoning of metro shield intervals
Authors: Wang Wei , Wang Xing , ZHOU xun , WEI shengda 
Published: September 2023

Abstract
Surface settlement is inevitable in underpass tunnel construction, but risk visualization can effectively control surface settlement and building deformation. Engineering monitoring and ground investigation data as sample database Taking engineering monitoring and ground survey data as sample database, the evaluation factors such as building height and groundwater depth are selected based on remote sensing model relying on GIS platform, and the model and engineering data are superimposed, counted and analyzed. The deterministic coefficient model, logistic regression model and combined CF-LR model were used for subsidence sensitivity analysis, respectively, and the frequency ratios and ROC curves of the three models were compared for accuracy, and the following conclusions were drawn: The area of different settlement risk sub-areas to the total sub-area is 23.0% for high and very high risk, 11.0% for medium risk and 66.0% for low and very low risk, visualizing the settlement risk in the area affected by the construction of the shield interval. The frequency ratio of very high settlement-prone areas in the combined model is 4.728, which is higher than that of the Certainty Factor model at 3.841 and the logistic regression model at 4.672. The success rate of the ROC curve of the combined model is 0.815 and the prediction rate is 0.832, both of which are better than that of the single model. The combined model has higher accuracy and reduces the proportion of fuzzy risk areas. The results of the study can provide a theoretical and methodological basis for the prevention and control of subsidence risk in the study area.
One-pot green solid-state synthesis of Cu2O/microcrystalline cellulose composite with high anti-pathogenic activity
Authors: Liu Yi , Sun Ke , Hu Han , He Zirong , Xiao Zhuojun , Jin Xiaoqian , Zheng Chen 
Published: September 2023

Abstract
Cuprous oxide (Cu2O) is proven as an excellent anti-harmful microbial material. However, the liquid and vapor phase preparation methods reported so far hardly make pure Cu2O-containing composites and suffer environment issues caused by chemical reducing agents with multiple processing steps. This work develops a facile one-pot solid-state sintering method to synthesize Cu2O/microcrystalline cellulose (MCC) composite via the thermal decomposition and oxidation-reduction reactions where copper formate was reduced by MCC. The Cu2O/MCC composite exhibits superior purity, dispersibility, stability, high yield, and high efficacy of antibacterial and antiviral properties, e.g., against E. coli, S. aureus, and Equine Arteritis Viral. This work utilizes elegantly the strong reducing capability of cellulose to develop an environmentally benign method to prepare high purity Cu2O-polymer composites with low cytotoxicity and cost, which can be incorporated readily into other substrate materials to form various forms of anti-harmful microbial materials widely used in public health care products.
Effect of Logistics Activities on Operational Performance of
Bedele Brewery Share Company
Authors: Hinkosa Jabessa , Tadele Amanuel 
Published: September 2023

Abstract
Nowadays, the role of logistics is increasingly recognized worldwide & its management was vital for the competitiveness of any firms’ weather manufacturing or service. An overall logistics activity was crucial for the day to day activities of any firms. The purpose of this study was to investigate the effect of logistics activities on operational performance of Bedele Brewery Share Company. The study has used explanatory and descriptive research design with both qualitative and quantitative approach. The study used both probability and non- probability sampling techniques. From the total of 395 employees working in the company’s production (operation), sales and transportation management, materials management, quality assurance, and warehousing departments; primary source of data were used. Questionnaire was distributed for 195 employees out of them186 was returned and analyzed with the help of SPSS version-25. Reliability of the instrument was tested by using Cronbach Alpha coefficient and pilot testing. Correlation analysis was used to determine the relationship between operational performance and logistics activities. In addition, regression analysis was used to analyze the effect of logistics activities on operational performance. The findings of the study revealed that transportation and inventory management, procurement practice, information flow and warehousing have significant positive effect on operational performance. In order to improve operational performance of the company, Bedele Brewery Share Company should upgrade investment on infrastructure for transportation of raw materials within Company. Using principle of economic order quantity that enables effective inventory management is also recommendable.
Screening of Indian mustard (Brassica juncea Linn. Czern &amp; Coss) germplasm against mustard aphid, Lipaphis erysimi pseudobrassicae (Kaltenbach, 1843)
Authors: Khan Nawaz Ahmad , Dubey Vinod Kumar , Mishra Anurag , Murugesh Tamilarasi , Dwivedi Devendra Kumar , Singh Hemant Kumar 
Published: September 2023

Abstract

Indian mustard (Brassica juncea Linn. Czern & Coss) is the important sources of edible oil in India. Its yield is declining due to several biotic stress like insect pests and disease. Out of the biotic stress the insect pests are more severe during the reproductive stages. Among the insect pests of mustard, aphid, Lipaphis erysimi pseudobrassicae (Kaltenbach, 1843) (Homoptera: Aphididae) is a destructive pest of Indian mustard prevalent in warm and humid regions of the world, especially in the eastern parts of South Asia. For the management of this aphid, the most effective ecofriendly measure to develop resistant cultivar. Thus, the present investigation was carried out to confirm L. e. pseudobrassicae resistance germplasm based on visual observations. These germplasms were screened for L. e. pseudobrassicae resistance in the natural conditions during 2020-21 and 2021-22 along with one susceptible check (Varuna) and one resistant check (Pusa Gaurav). During both the experimental year at flowering stage only one germplasm used as resistant check (Pusa Gaurav) reported under resistant category, moderately resistance (9, 7), susceptible category (32, 34) and none of the germplasm found highly susceptible in both the year. At the pod setting stage (2020-21 and 2021-22) the germplasm Pusa Gaurav used as resistant check reported under resistance category, 10 germplasm in moderately resistance category, the 31 germplasm under susceptible category, and none of the germplasm recorded as highly susceptible. These newly identified resistant germplasm could be used by mustard breeders for developing L. e. pseudobrassicae resistant mustard varieties.
Delineation of Regional Aquifer Parameters for Groundwater Exploration at Kurna, Kano
Authors: Musa Salisu , Darma TIjjani Hassan , Saleh Muhammad , L.S Mojereola 
Published: September 2023

Abstract
Availability of portable water is a global challenge which has necessitated search for additional sources of water. The global focus now is on groundwater which on its own, is only available in abundance at certain locations. The search for groundwater potential to meet increasing demand of the populace is very important in order to sustain livelihood of the populace and to sustain industrial development. Kurna in Dala Local Government of Kano is one of the most densely populated area in Kano known for its scarcity of portable water. There are various method of investigating groundwater potential depending on the terrain and availability of equipment. A geo-electrical investigation was conducted to delineate the regional aquifer parameters for groundwater exploration in some parts of Kurna, Kano. 30 vertical electrical soundings (VES) points were carried out in different locations to determine the possible regions of high aquifer potential. The interpreted data was used to develop geo-electric/geologic sections and contoured the aquifer thickness and resistivity maps. The results show that, the study area is underlain by two, three and four geological layers. The interpreted data shows that the topsoil resistivity and thickness vary between 5.0 Ωm – 102 Ωm and 1.5m – 38m respectively. While the resistivity and thickness of the second layer vary between 3.0Ωm – 968Ωm and 2.0m – 58m respectively. The last layer is characterized with high resistivity values of up to 56229Ωm with an infinite thickness and it is the fresh basement complex of the study area. Based on these aquifer parameters, the VES points with relatively low resistivity and high thickness values of the weathered/fractured basement have been successfully delineated as the targets for aquifer promising zones for groundwater development.