bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Warming Challenges Verification of Frost Advisories and Freeze Warnings in Madison, Wisconsin
Authors: Williamson Meirah , Kucharik Christopher J. 
Published: April 2023

Abstract
Urban heat islands (UHIs) may increase the likelihood that frost sensitive plants will escape freezing nighttime temperatures in late spring and early fall. Using data from 151 temperature sensors in the Madison, Wisconsin, region during March 2012–October 2016, we found that during time periods when the National Weather Service (NWS) issued freeze warnings (threshold of 0.0°C) or frost advisories (threshold of 2.22°C) were valid, temperatures in Madison’s most densely populated, built-up areas often did not fall below the respective temperature thresholds. Urban locations had a mean minimum temperature of 0.72° and 1.39°C for spring and fall freeze warnings, respectively, compared to −0.52° and −0.53°C for rural locations. On average, 31% of the region’s land area experienced minimum temperatures above the respective temperature thresholds during freeze warnings and frost advisories, and the likelihood of temperatures falling below critical temperature thresholds increased as the distance away from core urban centers increased. The urban–rural temperature differences were greatest in fall compared to spring, and when sensor temperatures did drop below thresholds, the maximum time spent at or below thresholds was highest for rural locations during fall freeze warnings (6.2 h) compared to urban locations (4.8 h). These findings potentially have widely varying implications for the general public and industry. UHIs create localized, positive perturbations to nighttime temperatures that are difficult to account for in forecasts; therefore, freeze warnings and frost advisories may have varying degrees of verification in medium-sized cities like Madison, Wisconsin, that are surrounded by cropland and natural vegetation.

Significance Statement
The purpose of this study was to understand whether the urban heat island effect in Madison, Wisconsin, creates localized temperature patterns where county-scale frost advisories and freeze warnings may not verify. Approximately one-third of Madison’s urban core area and most densely populated region experienced temperatures that were consistently above critical low temperature thresholds. This is important because gardening and crop management decisions are responsive to the perceived risk of cold temperatures in spring and fall that can damage or kill plants. These results suggest that urban warming presents forecast challenges to the issuance of frost advisories and freeze warnings, supporting the need for improved numerical weather prediction at higher spatial resolution to account for complex urban meteorology.
Correlates of poor clinical outcomes related to COVID-19 among older people with psychiatric illness - a mixed methods study
Authors: Abdulrahman Surajudeen , Al-Balushi Naser , Holdcroft-Long Jason , Khan Uzma , Ravindran Bipin , Das Sujata , Rajkumar Anto P 
Published: April 2023

Objective COVID-19 may lead to a range of clinical outcomes among older people with psychiatric and medical conditions. Evidence guiding management of future outbreaks among this vulnerable population in psychiatric hospital settings are sparse. In this study, we examined the correlates of poor clinical outcomes related to COVID-19 and explored the perspectives of COVID-19 survivors hospitalized in psychiatry settings. Method The correlates of poor clinical outcomes related to COVID-19 were examined using a retrospective chart review of 81 older people hospitalized in psychiatry settings. Correlates of clinical outcomes related to COVID-19 were assessed by multiple logistic regression models. In addition, the perspectives of 10 COVID-19 survivors were explored by qualitative interviews. The qualitative data was subject to thematic analysis. Results Although 25.9% (n = 21) participants were asymptomatic, there was high COVID-19 related mortality (14.8%; n = 12). Vitamin-D deficiency, anticholinergic burden, and isolation policies within psychiatric wards were significantly ( p < 0.05) related to COVID-19 related deaths. In qualitative interviews, participants emphasized the importance of strengthening local support networks and making vaccination centers more accessible. Conclusions Reducing anticholinergic prescriptions and improving isolation policies may help to mitigate poor clinical outcomes. Future research investigating the impact of vitamin-D supplementation on COVID-19 related outcomes is warranted.
Hyperlactatemia and poor outcome After postcardiotomy veno-arterial extracorporeal membrane oxygenation: An individual patient data meta-Analysis
Authors: Biancari Fausto , Kaserer Alexander , Perrotti Andrea , Ruggieri Vito G , Cho Sung-Min , Kang Jin Kook , Dalén Magnus , Welp Henryk , Jónsson Kristján , Ragnarsson Sigurdur , Hernández Pérez Francisco J , Gatti Giuseppe , Alkhamees Khalid , Loforte Antonio , Lechiancole Andrea , Rosato Stefano , Spadaccio Cristiano , Pettinari Matteo , Mariscalco Giovanni , Mäkikallio Timo , Sahli Sebastian D , L’Acqua Camilla , Arafat Amr A , Albabtain Monirah A , AlBarak Mohammed M , Laimoud Mohamed , Djordjevic Ilija , Krasivskyi Ihor , Samalavicius Robertas , Puodziukaite Lina , Alonso-Fernandez-Gatta Marta , Spahn Donat R , Fiore Antonio 
Published: April 2023

Introduction Postcardiotomy veno-arterial extracorporeal membrane oxygenation (V-A-ECMO) is associated with significant mortality. Identification of patients at very high risk for death is elusive and the decision to initiate V-A-ECMO is based on clinical judgment. The prognostic impact of pre-V-A-ECMO arterial lactate level in these critically ill patients has been herein evaluated. Methods A systematic review was conducted to identify studies on postcardiotomy VA-ECMO for the present individual patient data meta-analysis. Results Overall, 1269 patients selected from 10 studies were included in this analysis. Arterial lactate level at V-A-ECMO initiation was increased in patients who died during the index hospitalization compared to those who survived (9.3 vs 6.6 mmol/L, p < 0.0001). Accordingly, in hospital mortality increased along quintiles of pre-V-A-ECMO arterial lactate level (quintiles: 1, 54.9%; 2, 54.9%; 3, 67.3%; 4, 74.2%; 5, 82.2%, p < 0.0001). The best cut-off for arterial lactate was 6.8 mmol/L (in-hospital mortality, 76.7% vs. 55.7%, p < 0.0001). Multivariable multilevel mixed-effect logistic regression model including arterial lactate level significantly increased the area under the receiver operating characteristics curve (0.731, 95% CI 0.702–0.760 vs 0.679, 95% CI 0.648–0.711, DeLong test p < 0.0001). Classification and regression tree analysis showed the in-hospital mortality was 85.2% in patients aged more than 70 years with pre-V-A-ECMO arterial lactate level ≥6.8 mmol/L. Conclusions Among patients requiring postcardiotomy V-A-ECMO, hyperlactatemia was associated with a marked increase of in-hospital mortality. Arterial lactate may be useful in guiding the decision-making process and the timing of initiation of postcardiotomy V-A-ECMO.
Cross-sectional survey of smartphone addiction and its relationship with personality traits among medical students
Authors: Huang Xing , Yang Haijun , Wei Sha , Wang Yan 
Published: April 2023

Objective To understand the current smart phone addiction tendency (SPAT) in medical university students and relationship with personality traits. Methods A cross-sectional study from September 2019 to December 2019 selected medical students from Hubei University of China by cluster sampling. Questionnaires were administered to measure smart phone addiction tendency and personality traits. Results The prevalence of SPAT among 972 medical students was 24.3%. The prevalence was higher in students from one-child family than those with siblings (28.2% vs. 21.7%), and higher among students from urban families than those from rural ones (29.2% vs. 19.7%).Multivariate logistic regression analysis showed that extraversion and neuroticism were correlated with SPAT, with odds ratio and 95% confidence interval being equal to 1.070 (1.011–1.133) and 0.838 (0.795–0.844), respectively. Conclusions The prevalence of SPAT was high in medical college students. Extraversion and neuroticism were risk and protective factors for SPAT. Long duration phone use and a low number of physical workouts predicted high SPAT.
Clinicopathologic Classification of Renal Cell Carcinoma in Patients ≤40 Years Old From Peru
Authors: Kamanda Sonia , Huanca-Amesquita Lourdes , Milla Esperanza , Argani Pedram , Epstein Jonathan I. 
Published: April 2023

Introduction There are scant data on renal cell carcinoma (RCC) from relatively younger patients in South America using contemporary classification. Methods Fifty-nine consecutively treated patients with RCC (≤40 years old) were assessed from the National Institute of Neoplastic Diseases in Peru from 2008 to 2020 (34 males; 25 females), age range of 13 to 40 years. Results Most common presenting symptoms were flank pain (n = 40), hematuria (n = 19), and weight loss (n = 12). Associated conditions included 4 patients with proven or presumed tuberous sclerosis and 1 patient with von Hippel Lindau syndrome, all with clear cell RCC. Tumor histopathology was clear cell RCC in 32 of 59 (54%), chromophobe RCC in 6 of 59 (10%), and 5 of 59 (8%) each of papillary RCC and MiT family translocation-associated RCC. Four of 59 (7%) were FH-deficient RCC and 2 of 59 (3%) remained unclassified. The remaining tumors were isolated examples of clear cell papillary renal cell tumor, eosinophilic solid and cystic RCC (ESC RCC), RCC with fibromyomatous stroma, sarcomatoid RCC, and sarcomatoid clear cell RCC. Of the 4 FH-deficient RCCs, none had the classic morphology. The 5 MiT family translocation RCCs had variable morphology. There were 41 tumors without recurrence or metastases, 3 tumors with local recurrence only, 8 tumors with metastases only, and 7 tumors with both local recurrence and metastases. Conclusions The current study demonstrates the importance of special studies in accurately classifying RCC in younger individuals. The distribution of RCC subtypes in younger individuals is similar between 2 representative large institutions of the United States and Peru.
Tele-assessment of activities and participation in chronic phase of stroke: Is use valid and viable in a developing country?
Authors: Oliveira Léia Cordeiro de , dos Santos Heyriane Martins , da Silva Mariana Acciarini , de Oliveira Bianca Stefany Lima , de Lima Taiane Silva , Pereira Gabriela Santos , Silva Soraia Micaela 
Published: April 2023

Background SATISPART-Stroke (SATIS-Stroke) is the most complete instrument for the assessment of activity and participation following a stroke. However, its use in a developing country has only been tested through in-person interviews. Objective To determine the validity, reproducibility and viability of the SATIS-Stroke scale administered in two tele-assessment modalities: self-assessment of an electronic form versus videoconference. Methods Methodological study with Brazilian chronic stroke survivors was conducted. Stage I comprised an in-person interview to apply the SATIS-Stroke and a self-assessment by completing an electronic form to respond to the SATIS-Stroke items. Step II occurred 6 to 8 months after Step I, during which SATIS-Stroke was administered again in-person and via videoconference. The order was randomized. Results Ninety-five stroke survivors were recruited, but only 50 answered the electronic form (adherence: 52.6%). Mean scores were higher in the self-administration of electronic form compared to the in-person interview (mean difference = −0.36 ± 0.93; P = 0.009). Adequate reliability was found in the comparison of the in-person and self-assessment of electronic form (ICC2,1 = 0.66; 95%CI: 0.40–0.81). Fifty stroke survivors participated in Step II, during which adequate reliability was found in the comparison of the in-person administration and videoconference (ICC2,1 = 0.55; 95%CI: 0.21–0.74) and a moderate correlation was found between the assessment methods ( r = 0.43; P = 0.02). Discussion Adequate validity and reliability were found in the tele-assessment. Thus, this method is appropriate and viable for use in developing countries. Although reliable, the self-assessment did not have good adherence in the Brazilian population due to internet access problems, lack of familiarity with the digital form and lack of autonomy to answer the questions alone.
Annulus Fibrosus Repair for Lumbar Disc Herniation: A Meta-Analysis of Clinical Outcomes From Controlled Studies
Authors: Wang Yangbin , He Xiaoyu , Chen Shupeng , Weng Yiyong , Liu Zhihua , Pan Qunlong , Zhang Rongmou , Li Yizhong , Wang Hanshi , Lin Shu , Yu Haiming 
Published: April 2023

Study Design Meta-analysis . Objectives This study aimed to summarize the clinical efficacy and safety of the various annular defect repair methods that have emerged in recent years. Methods A meta-analysis of randomized and non-randomized controlled trials was conducted. Articles from PubMed, Embase, and the Cochrane Library (CENTRAL) on Lumbar disc herniation treatment with annular repair published from inception to April 2, 2022 were included. We summarized the clinical efficacy and safety of annular repair techniques based on a random-effects model meta-analysis. Results 7 randomized controlled studies and 8 observational studies with a total of 2161 participants met the inclusion criteria. The pooled data analysis showed that adding the annular repair technique reduced postoperative recurrence rate, reoperation rate, and loss of intervertebral height compared with lumbar discectomy alone. Subgroup analysis based on different annular repair techniques showed that the Barricaid Annular Closure Device (ACD) was effective in preventing re-protrusion and reducing reoperation rates, while there was no significant difference between the other subgroups. The annulus fibrosus suture (AFS) did not improve the postoperative Oswestry Disability Index (ODI). No statistically significant difference was observed in the incidence of adverse events between the annular repair and control groups. Conclusions Lumbar discectomy combined with ACD can effectively reduce postoperative recurrence and reoperation rates in patients with LDH. AFS alone was less effective in reducing recurrence and reoperation rates and did not improve postoperative pain and function.
Comparison between Ultrasound and Fluoroscopy-guided Percutaneous Nephrolithotomy (PCNL) at Raden Mattaher Jambi Hospital
Authors: Fauzan Randy , Manduaru Raga , Sitompul Ardiansyah Periadi , Rachman Wendi , Herman Hendra 
Published: April 2023

Abstract
Purpose
To investigate the effectiveness and safety of ultrasound-guided and Percutaneous Nephrolithotomy (PCNL) compared to the standard fluoroscopy-guided PCNL.

Methods
This study is a comparative retrospective study obtained from medical records within the last 5 years of Raden Mattaher Hospital, Jambi. Patients were divided into 2 groups, fluoroscopy- and ultrasonography-guided PCNL with large kidney stone > 20 mm. Patient characteristics were divided into pre- and post-operative procedures and analyzed using SPSS ver. 25.0 (SPSS Inc., Chicago, IL, USA). Data were analyzed using Kolmogorov–Smirnov, chi-square and/ Fischer’s exact test and p value < 0.05 was considered statistically significant.

Results
Of 201 patients’ data from medical records were divided into ultrasound-guided and fluoroscopy-guided groups. Ultrasound-guided group were consisted of 89 patients and fluoroscopy-guided were of 112 patients. US Guided significantly identifies the severity of hydronephrosis compared to PCNL. The demographic data obtained age, sex, body mass index, and preoperative hemoglobin levels showed a normal distribution. On the post-operative results, significant results occurred in post-PCNL stent placement. Installation of a DJ stent alone is more commonly performed on fluoroscopy-guided PCNL procedures compared to ultrasound-guided PCNL. This had a positive impact on post-procedure outcomes, meaning that the post-operative outcome of ultrasound-guided PCNL was better than that of fluoroscopy-guided PCNL.

Conclusion
The reported data demonstrate that PCNL and ultrasound-guided has similar efficacy and complication rates with PCNL fluoroscopy-guided. This could be a good alternative in urological centers with no access to fluoroscopy. However, ultrasound-guided group was still associated with higher rate nephrostomy tube placement and longer surgery duration.
Resuscitation room management of patients with non-traumatic critical illness in the emergency department (OBSERvE-DUS-study)
Authors: Dziegielewski Janina , Schulte Falko C. , Jung Christian , Wolff Georg , Hannappel Oliver , Kümpers Philipp , Bernhard Michael , Michael Mark 
Published: April 2023

Abstract
Background
Few studies address the care of critically ill non-traumatic patients in the emergency department (ED). The aim of this study was to assess the epidemiology, management, and outcome of these patients.

Methods
In this retrospective study, we identified and analyzed data from all consecutive adult critically ill non-traumatic ED patients treated from March 2018 to February 2019. Patient characteristics, major complaint leading to admission, out-of-hospital, and in-hospital interventions and 30-day mortality were extracted from medical records of the electronic patient data management system.

Results
During the study period, we analyzed 40,764 patients admitted to the ED. Of these, 621 (1.5%) critically ill non-traumatic patients were admitted for life-threatening emergencies to the resuscitation room (age: 70 ± 16 years, 52% male). Leading problem on admission was disability/unconsciousness (D), shock (C), respiratory failure (B), airway obstruction (A), and environment problems (E) in 41%, 31%, 25%, 2%, and 1%, respectively. Out-of-hospital and in-hospital measures included: intravenous access (61% vs. 99%), 12-lead ECG (55% vs. 87%), invasive airway management (21% vs. 34%) invasive ventilation (21% vs. 34%), catecholamines (9% vs. 30%), arterial access (0% vs. 52%), and cardiopulmonary resuscitation (11% vs. 6%). The underlying diagnoses were mainly neurological (29%), followed by cardiological (28%), and pulmonological (20%) emergencies. The mean length of stay (LOS) in the resuscitation room and ED was 123 ± 122 and 415 ± 479 min, respectively. The 30-day mortality was 18.5%.

Conclusion
The data describe the care of critically ill non-traumatic patients in the resuscitation room. Based on these data, algorithms for the structured care of critically ill non-traumatic patients need to be developed.
‘I believe respect means providing necessary treatment on time’ - a qualitative study of health care providers’ perspectives on disrespect and abuse during childbirth in Southwest Ethiopia
Authors: Werdofa Hirut Megersa , Thoresen Lisbeth , Lulseged Belayneh , Lindahl Anne Karin 
Published: April 2023

Abstract
Background
The majority of maternal deaths occur in low-income countries, and facility-based childbirth is recognised as a strategy to reduce maternal mortality. However, experiences of disrespect and abuse during childbirth are reported as deterrents to women’s utilisation of health care facilities. Health care providers play a critical role in women’s experiences during childbirth; yet, there is limited research on service providers’ views of disrespect and abuse in Ethiopia. Therefore, this study aimed to explore providers’ perspectives on disrespect and abuse during childbirth in a teaching hospital in Southwest Ethiopia.

Method
Qualitative study was conducted in a tertiary teaching hospital in Jimma Ethiopia. In-depth interviews were conducted with 32 purposefully selected health care providers, including midwives, obstetrics and genecology resident’s, senior obstetricians and nurses. Interviews were audio-recorded, transcribed and thematically analysed using the qualitative data analysis software program MAXQDA.

Results
Three major themes were identified from the health care providers’ perspectives: (1) respectful and abuse-free care, (2) recognised disrespect and abuse; and (3) drivers of women’s feelings of disrespect and abuse. The first theme indicates that most of the participants perceived that women were treated with respect and had not experienced abuse during childbirth. The second theme showed that a minority of the participants recognised that women experienced disrespect and abuse during childbirth. The third theme covered situations in which providers thought that drivers for women felt disrespected.

Conclusion
Most providers perceived women’s experiences as respectful, and they normalized, and rationalized disrespect and abuse. The effect of teaching environment, the scarcity of resources has been reported as a driver for disrespect and abuse. To ensure respectful maternity care, a collaborative effort of administrators, teaching institutions, professional associations and researchers is needed. Such collaboration is essential to create a respectful teaching environment, ensure availability of resources, sustained in-service training for providers, and establishing an accountability mechanism for respectful maternity care.
The V protein in oncolytic Newcastle disease virus promotes HepG2 hepatoma cell proliferation at the single-cell level
Authors: Chu Zhili , Yang Sihui , Li Qianru , Shang Jianing , Ren Zilong , Ren Feng 
Published: April 2023

Abstract
Background
Newcastle disease virus (NDV) is an oncolytic virus that can inhibit cancer cell proliferation and kill cancer cells. The NDV nonstructural V protein can regulate viral replication; however, whether the V protein contributes to NDV oncolysis is unclear.

Results
This study revealed that NDV inhibited tumor cell proliferation and that V protein expression promoted the proliferation of HepG2 cells, as determined at the single-cell level. In addition, to identify the regulatory mechanism of the V protein in HepG2 cells, transcriptome sequencing was performed and indicated that the expression/activation of multiple cell proliferation-related genes/signaling pathways were changed in cells overexpressing the V protein. Hence, the MAPK and WNT signaling pathways were selected for verification, and after blocking these two signaling pathways with inhibitors, the V protein promotion of cell proliferation was found to be attenuated.

Conclusions
The results showed that the V protein regulated the proliferation of cancer cells through multiple signaling pathways, providing valuable references for future studies on the mechanism by which the V protein regulates cancer cell proliferation.