bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is in a name—Perifollicular fibroma or fibrofolliculoma?
Authors: Haneke Eckart , Happle Rudolf 
Published: August 2023

AbstractSo far, confusion exists regarding the question of whether hereditary perifollicular fibromas and fibrofolliculomas can be distinguished from each other. Here, histopathological arguments are presented to clarify this terminological problem. In 1977, Birt et al. described a large kindred affected with hereditary multiple “fibrofolliculomas,” which they thought were “a hitherto unrecognized pilar hamartoma,” but they never claimed the fibrofolliculomas were part of a syndrome. A careful microscopic comparison shows, however, that the tumors are clinically and histopathologically identical to perifollicular fibromas, as first described by Burnier and Rejšek in 1925. Their familial occurrence was discovered in 1971 by Civatte and Le Tréguilly. Before 1977, the term “perifollicular fibroma” was used for these skin tumors. By contrast, Hornstein and Knickenberg described in 1975 perifollicular fibromas as a cutaneous marker of a syndrome characterized by a predisposition to colon cancer and pneumothorax. Later, two French groups erroneously proposed the term “Birt–Hogg–Dubé syndrome” to describe the co‐occurrence of fibrofolliculomas, trichodiscomas, and acrochordons, which was contrary to what Birt et al. had in mind. Hence, today, we should discriminate between the hereditary nonsyndromic perifollicular fibromas, as documented by Civatte and Le Tréguilly and later by Birt et al., and the syndromic perifollicular fibromas, as delineated by Hornstein and Knickenberg.
Incorporation of colonization pressure into the propagule pressure‐based global ballast water standard
Authors: Hernandez Marco R. , Barker Justin R. , MacIsaac Hugh J. 
Published: August 2023

AbstractAimIn 2024, cargo vessels must meet the International Maritime Organization's global ballast water discharge standards (IMO D‐2) that limit the concentration of living organisms. D‐2 focuses on reducing invasion risk by reducing ‘community propagule pressure (CPP)’, though it does not consider colonization pressure (CP).LocationGlobal.MethodsWe modelled risk differences in IMO D‐2‐compliant discharges (10 ind. m−3) for communities that had inverse patterns of CP and species' individual propagule pressures (IPP). Secondly, we determined the effect on risk of varying CPP and CP. As part of this, we tested whether the IMO D‐2 standard for zooplankton‐sized organisms of <10 individuals m−3 was an optimal choice. Risk was defined as probability of at least one species invading using four risk–release models.ResultsRisk differed strongly at the D‐2 limit based on community composition. At low CPP (<25 ind. m−3), risk was strongly affected by CP for hyperbolic and linear risk–release models and weakly for exponential and logistic models, while CPP affected only the former two model types. Across a much wider range of CPP values, risk was affected by CP, CPP and by their interaction for all models.Main ConclusionThe IMO D‐2 standard for zooplankton‐sized organisms requires very low CPP and even lower IPPs in mixed‐species releases, which will impede successful colonization. Species‐abundance theory predicts that discharges meeting the D‐2 standard (low CPP) will also have low CP. Much more empirical data are required to determine whether vessels can consistently reduce CP as it lowers CPP in order to meet these requirements.
Lived experience adaptation of a psychosocial intervention for young adults with bipolar spectrum disorders: Process description and adaptation outcomes
Authors: Hawke Lisa D. , Bennett Rachel , Sheikhan Natasha Y. , Yanos Philip 
Published: August 2023

AbstractAimLived experience adaptation of mental health interventions can help ensure that the intervention is appropriate for the target population. This paper describes a youth‐led adaptation of a self‐stigma reduction intervention for young adults with bipolar spectrum disorders, that is, Narrative Enhancement and Cognitive Therapy.MethodsStandard guidelines for youth engagement were followed. A youth lived experience adaptation lead and a five‐member youth lived experience advisory panel reviewed the intervention and made a number of adaptations to increase its relevance for young people with bipolar disorders. A brief evaluation of the engagement process was conducted.ResultsThe primary adaptations made to the intervention fell into five areas: (1) wording revisions for recovery‐oriented language accessible to youth with a wide variety of language and literacy levels; (2) updating and tailoring to the diagnostic category, with the addition of new quotes describing the lived experience of stigma; (3) integration of a new, engaging graphic design; (4) development of a goal‐setting module, as recommended by the research team; and (5) identification of the role of a peer co‐facilitator. An evaluation of the engagement process showed that the engagement was extremely meaningful for the youth engaged.ConclusionsUsing a youth lived experience adaptation process, young people can make relevant, important changes to a psychosocial intervention. The resulting early intervention materials are research‐ready and are hypothesized to meet the needs of young people with BD in a youth‐friendly manner. Research on the acceptability, efficacy, and effectiveness of the newly adapted intervention will be required.
Use of digital tools for preclinical training in complete denture: A pilot study
Authors: Porcherot Audrey , Maniani Imane , Berteretche Marie‐Violaine , Citterio Hélène , Fromentin Olivier , Rignon‐Bret Christophe , Braud Adeline , Wulfman Claudine 
Published: August 2023

AbstractIntroductionAdvances in CAD–CAM complete dentures open up opportunities in preclinical laboratory education. A cross‐over study was conducted to assess the benefit of digital training in custom tray fabrication. Hypotheses were that digital training improved conceptual skill acquisition and that assessment of digital work helps in the discrimination of students' difficulty.Materials and MethodsThird‐year students were allocated either into group A and took the manual practical classes before the digital ones, or into group B (N = 154). Prior to the sessions, a motor skill test was conducted. The influence on the learning process was evaluated by comparing the groups' results to the manual lab work with a Student's t‐test. The effectiveness of the assessment in discriminating manual aptitude and conceptual skill was studied through Spearman's rank coefficient between digital and manual scores in conceptual skill and with a subgroup analysis according to the results of the motor skill test. The level of significance was set up at .05. Students' satisfaction was also assessed with a questionnaire.ResultsStudents in group B achieved better scores. Spearman's rank coefficient test showed a weak correlation, R = .16. For manual lab work, the most manually skilled students did significantly better. In contrast, for the digital session, the medium manually skilled students did better. More than half of the students (55%) found the manual and digital sessions complementary, without identifying any difference depending on the learning sequence.ConclusionDigital training improved the students' results in the conventional practical exercise. Assessments of the digital and conventional custom trays were complementary in order to distinguish conceptual and motor skills.
A novel automatic release cage increases survival of Atlantic salmon (Salmo salar) smolts released at night
Authors: Glover Ross S. , Stephen Alastair 
Published: August 2023

AbstractTrap‐and‐transport of migratory fish is commonly used to bypass in‐river obstructions. On the River Conon in Scotland, Atlantic salmon (Salmo salar) smolts are transported around two hydropower facilities. Smolt release occurs during daylight, when predation rates can be high. A novel automatic release cage (ARC) was designed to release smolts at night. Smolts were fitted with acoustic tags (n = 99) to compare survival. High post‐release mortality was identified in the day‐release group, with night‐release survival >40% higher. ARCs can provide fishery managers with a cost‐effective and reliable method of improving smolt survival.
The distribution of subarctic and boreal deep‐sea demersal fish assemblages across environmental gradients of the northwest Atlantic
Authors: Cote David , Sutton Jordan , Roul Sheena , Murua Hilario , Gonzales Fernando , Alpoim Ricardo , Angnatok Joey 
Published: August 2023

AbstractThe oceanography of the Labrador Sea is well studied because of its globally important deep‐water convection that oxygenates the deep ocean and drives climate‐regulating ocean currents. However, little is known about the fish communities that inhabit this area, particularly beyond the depths accessible to standard research surveys and commercial fishing activities. We used baited longline surveys to characterize important components of demersal fish communities across a depth gradient of 200–3000 m and compared these data to a similar dataset collected c. 1200 km to the south in the Flemish Cap Region. We found demersal fish communities in the Labrador Sea to be similar to those of the Flemish Cap Region despite unique oceanography and lower primary productivity in the Labrador Sea. Moreover, both areas had high abundance, biomass, and species richness at intermediate depths that suggests factors beyond depth drive community structure in the deep ocean. These data are important for identifying high‐value areas for potential protective measures in the northwest Atlantic and provide necessary data with which to assess potential environmental impacts of extractive industries that are expanding north and to deeper waters.
The mammalian gastro‐intestinal tract is a NOT a major extra‐pineal source of melatonin
Authors: Kennaway David J. 
Published: August 2023

AbstractIn 1992, a paper reported that the melatonin content of the rat duodenum was 24 000 ± 2000 pg/g tissue (range: 4000–100 000 pg/g) while the pineal melatonin content was 580 000 ± 36 000 pg/g. The data has been used for the last 30 years to infer that the gut produces 400 hundred times more melatonin than the pineal gland and that it is the source of plasma melatonin during the daytime. No‐one has ever challenged the statement. In this review, evidence is summarised from the literature that pinealectomy eliminates melatonin from the circulation and that studies to the contrary have relied upon poorly validated immunoassays that overstate the levels. Similarly studies that have reported increases in plasma melatonin following tryptophan administration failed to account for cross reactivity of tryptophan and its metabolites in immunoassays. The most extraordinary observation from the literature is that in those studies that have measured melatonin in the gut since 1992, the tissue content is vastly lower than the original report, even when the methodology used could be overestimating the melatonin content due to cross reactivity. Using the more contemporary results we can calculate that rather than a 400:1 ratio of duodenum: pineal melatonin, a ratio of 0.05–0.19: 1 is likely. The gut is not a major extra‐pineal source of melatonin; indeed it may well not produce any.
From gestational chronodisruption to noncommunicable diseases: Pathophysiological mechanisms of programming of adult diseases, and the potential therapeutic role of melatonin
Authors: Méndez Natalia , Corvalan Fernando , Halabi Diego , Ehrenfeld Pamela , Maldonado Rodrigo , Vergara Karina , Seron‐Ferre Maria , Torres‐Farfan Claudia 
Published: August 2023

AbstractDuring gestation, the developing fetus relies on precise maternal circadian signals for optimal growth and preparation for extrauterine life. These signals regulate the daily delivery of oxygen, nutrients, hormones, and other biophysical factors while synchronizing fetal rhythms with the external photoperiod. However, modern lifestyle factors such as light pollution and shift work can induce gestational chronodisruption, leading to the desynchronization of maternal and fetal circadian rhythms. Such disruptions have been associated with adverse effects on cardiovascular, neurodevelopmental, metabolic, and endocrine functions in the fetus, increasing the susceptibility to noncommunicable diseases (NCDs) in adult life. This aligns with the Developmental Origins of Health and Disease theory, suggesting that early‐life exposures can significantly influence health outcomes later in life. The consequences of gestational chronodisruption also extend into adulthood. Environmental factors like diet and stress can exacerbate the adverse effects of these disruptions, underscoring the importance of maintaining a healthy circadian rhythm across the lifespan to prevent NCDs and mitigate the impact of gestational chronodisruption on aging. Research efforts are currently aimed at identifying potential interventions to prevent or mitigate the effects of gestational chronodisruption. Melatonin supplementation during pregnancy emerges as a promising intervention, although further investigation is required to fully understand the precise mechanisms involved and to develop effective strategies for promoting health and preventing NCDs in individuals affected by gestational chronodisruption.
A genome‐scale metabolic reconstruction of soybean and Bradyrhizobium diazoefficiens reveals the cost–benefit of nitrogen fixation
Authors: Holland Bethany L. , Matthews Megan L. , Bota Pedro , Sweetlove Lee J. , Long Stephen P. , diCenzo George C. 
Published: August 2023

Summary
Nitrogen‐fixing symbioses allow legumes to thrive in nitrogen‐poor soils at the cost of diverting some photoassimilate to their microsymbionts. Effort is being made to bioengineer nitrogen fixation into nonleguminous crops. This requires a quantitative understanding of its energetic costs and the links between metabolic variations and symbiotic efficiency.
A whole‐plant metabolic model for soybean (Glycine max) with its associated microsymbiont Bradyrhizobium diazoefficiens was developed and applied to predict the cost–benefit of nitrogen fixation with varying soil nitrogen availability.
The model predicted a nitrogen‐fixation cost of c. 4.13 g C g−1 N, which when implemented into a crop scale model, translated to a grain yield reduction of 27% compared with a non‐nodulating plant receiving its nitrogen from the soil. Considering the lower nitrogen content of cereals, the yield cost to a hypothetical N‐fixing cereal is predicted to be less than half that of soybean. Soybean growth was predicted to be c. 5% greater when the nodule nitrogen export products were amides versus ureides.
This is the first metabolic reconstruction in a tropical crop species that simulates the entire plant and nodule metabolism. Going forward, this model will serve as a tool to investigate carbon use efficiency and key mechanisms within N‐fixing symbiosis in a tropical species forming determinate nodules.
Dental evaluation and clearance prior to allogeneic hematopoietic cell transplantation
Authors: Dean David , Lee Stephanie J. , Cutler Corey , Gooley Ted A. , Hujoel Philippe , Oh Uhlee (Yuri) , Bennett‐Johnson Lisa , Hagstrom Mary K. , Rothen Marilynn , Lloid Michele , Sroussi Herve , Treister Nathaniel 
Published: August 2023

AbstractIntroductionDental examination and stabilization are performed prior to allogeneic hematopoietic cell transplantation to decrease infection risk during neutropenia. Burden of dental disease and treatment need is not well characterized in this population.ObjectivesThis report describes the dental status of a cohort of patients within the Chronic Graft‐versus‐Host Disease Consortium and treatment rendered prior to transplant.MethodsThe cohort included 486 subjects (Fred Hutchinson: n = 245; Dana‐Farber: n = 241). Both centers have institutional‐based dental clearance programs. Data were retrospectively abstracted from medical records by calibrated oral health specialists.ResultsThe median age at transplant was 55.9 years, 62.1% were male, and 88% were white. Thirteen patients were edentulous (2.7%). The mean teeth among dentate patients before clearance was 26.0 (SD, 4.6). Dental findings included untreated caries (31.2%), restorations (91.6%), endodontically treated teeth (48.1%), and dental implants (5.7%). Pretransplant procedures during clearance included endodontic therapy (3.6%; mean = 0.1 teeth), restorations (25.1%; mean = 0.7), dental prophylaxis (59.2%), scaling/root planing (5.1%), and extraction (13.2%; mean = 0.3). The mean teeth after clearance was 25.6 (SD, 5.0).ConclusionsRetrospective analysis of pre‐AlloHCT dental data in subjects at two large transplant centers identified low levels of dental need. Findings suggest high access to care.
Raman spectroscopy and U‐Net deep neural network in antiresorptive drug‐related osteonecrosis of the jaw
Authors: Matthies Levi , Gebrekidan Medhanie T. , Braeuer Andreas S. , Friedrich Reinhard E. , Stelzle Florian , Schmidt Constantin , Smeets Ralf , Assaf Alexandre T. , Gosau Martin , Rolvien Tim , Knipfer Christian 
Published: August 2023

AbstractObjectiveApplication of an optical method for the identification of antiresorptive drug‐related osteonecrosis of the jaw (ARONJ).MethodsWe introduce shifted‐excitation Raman difference spectroscopy followed by U‐Net deep neural network refinement to determine bone tissue viability. The obtained results are validated through established histological methods.ResultsDiscrimination of osteonecrosis from physiological tissues was evaluated at 119 distinct measurement loci in 40 surgical specimens from 28 patients. Mean Raman spectra were refined from 11,900 raw spectra, and characteristic peaks were assigned to their respective molecular origin. Then, following principal component and linear discriminant analyses, osteonecrotic lesions were distinguished from physiological tissue entities, such as viable bone, with a sensitivity, specificity, and overall accuracy of 100%. Moreover, bone mineral content, quality, maturity, and crystallinity were quantified, revealing an increased mineral‐to‐matrix ratio and decreased carbonate‐to‐phosphate ratio in ARONJ lesions compared to physiological bone.ConclusionThe results demonstrate feasibility with high classification accuracy in this collective. The differentiation was determined by the spectral features of the organic and mineral composition of bone. This merely optical, noninvasive technique is a promising candidate to ameliorate both the diagnosis and treatment of ARONJ in the future.
Long‐term outcomes, quality of life, and costs of treatment modalities for T1–T2 lip carcinomas
Authors: van Hof Kira S. , Wakkee Marlies , Sewnaik Aniel , Herkendaal Aimée F. , Tans Lisa , Mast Hetty , van den Bos Renate R. , Mureau Marc A. M. , Offerman Marinella P. J. , Baatenburg de Jong Robert J. 
Published: August 2023

AbstractPurposeEarly stage lip squamous cell carcinoma (lip SCC) can be treated with conventional excision, Mohs micrographic surgery (MMS), or brachytherapy. The aim of this retrospective study was to describe the medical outcomes, patient‐reported outcomes, and costs of these treatments.MethodsA retrospective cohort study of T1–T2 lip SSCs treated between 1996 and 2019. Medical outcomes, recurrences, and survival were retrieved from medical records. Facial appearance, facial function, and Quality of Life (QoL) were measured with the Face‐Q H&N and EQ‐5D‐5L questionnaires. Costs were also calculated.ResultsOf the 336 lip SCCs, 122 were treated with excision, 139 with MMS, and 75 with brachytherapy. Locally, the recurrence rate was 2.7% and regionally 4.8%. There were 2% disease‐related deaths. T2‐stage and poor tumor differentiation were associated with recurrences. Posttreatment QoL, facial function, and appearance were rated as good. Brachytherapy was the most expensive treatment modality.ConclusionEarly‐stage lip SCC has a good prognosis, with a disease‐specific survival of 98.2% after a median follow‐up of 36 months, there was a high QoL and satisfaction at long‐term follow‐up. Based on the costs and the risk of locoregional recurrences, we believe that, for most noncomplex lip SCCs, MMS would be the most logical treatment option.
ScAREB4 promotes potato constitutive and acclimated freezing tolerance associated with enhancing trehalose synthesis and oxidative stress tolerance
Authors: Liu Tiantian , Wang Jin , Chen Lin , Liu Shengxuan , Liu Tengfei , Yu Liu , Guo Jingjing , Chen Ye , Zhang Yiling , Song Botao 
Published: August 2023

AbstractCold is a major environmental factor that restrains potato production. Abscisic acid (ABA) can enhance freezing tolerance in many plant species, but powerful evidence of the ABA‐mediated signalling pathway related to freezing tolerance is still in deficiency. In the present study, cold acclimation capacity of the potato genotypes was enhanced alongside with improved endogenous content of ABA. Further exogenous application of ABA and its inhibitor (NDGA) could enhance and reduce potato freezing tolerance, respectively. Moreover, expression pattern of downstream genes in ABA signalling pathway was analysed and only ScAREB4 was identified with specifically upregulate in S. commersonii (CMM5) after cold and ABA treatments. Transgenic assay with overexpression of ScAREB4 showed that ScAREB4 promoted freezing tolerance. Global transcriptome profiling indicated that overexpression of ScAREB4 induced expression of TPS9 (trehalose‐6‐phosphate synthase) and GSTU8 (glutathione transferase), in accordance with improved TPS activity, trehalose content, higher GST activity and accumulated dramatically less H2O2 in the ScAREB4 overexpressed transgenic lines. Taken together, the current results indicate that increased endogenous content of ABA is related to freezing tolerance in potato. Moreover, ScAREB4 functions as a downstream transcription factor of ABA signalling to promote cold tolerance, which is associated with increased trehalose content and antioxidant capacity.
Expression of the far‐red D1 protein or introduction of conserved far‐red D1 residues into Synechocystis sp. PCC 6803 impairs Photosystem II
Authors: Sheridan Kevin J. , Brown Toby J. , Eaton‐Rye Julian J. , Summerfield Tina C. 
Published: August 2023

AbstractThe wavelengths of light harvested in oxygenic photosynthesis are ~400–700 nm. Some cyanobacteria respond to far‐red light exposure via a process called far‐red light photoacclimation which enables absorption of light at wavelengths >700 nm and its use to support photosynthesis. Far‐red‐light‐induced changes include up‐regulation of alternative copies of multiple proteins of Photosystem II (PS II). This includes an alternative copy of the D1 protein, D1FR. Here, we show that D1FR introduced into Synechocystis sp. PCC 6803 (hereafter Synechocystis 6803) can be incorporated into PS II centres that evolve oxygen at low rates but cannot support photoautotrophic growth. Using mutagenesis to modify the psbA2 gene of Synechocystis 6803, we modified residues in helices A, B, and C to be characteristic of D1FR residues. Modification of the Synechocystis 6803 helix A to resemble the D1FR helix A, with modifications in the region of the bound ß‐carotene (CarD1) and the accessory chlorophyll, ChlZD1, produced a strain with a similar phenotype to the D1FR strain. In contrast, the D1FR changes in helices B and C had minor impacts on photoautotrophy but impacted the function of PS II, possibly through a change in the equilibrium for electron sharing between the primary and secondary plastoquinone electron acceptors QA and QB in favour of QA−. The addition of combinations of residue changes in helix C indicates compensating effects may occur and highlight the need to experimentally determine the impact of multiple residue changes.