bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive decision support tool for chemotherapy cycle prescribing: a feasibility study
Authors: Iivanainen Sanna , Arokoski Reetta , Mentu Santeri , Lang Laura , Ekström Jussi , Virtanen Henri , Kataja Vesa , Koivunen Jussi Pekka 
Published: March 2023

Abstract

Background

Chemotherapy cycle prescription is generally carried out through a manual process. ICT tools with data analytics could streamline this process and limit human errors.

Methods

A one-arm multicenter prospective clinical trial ECHO 7/2019-1/2021 (NCT04081558) investigated the use of a novel Kaiku Health ePRO tool in cancer care. The most important patient inclusion criteria were colorectal cancer (CRC) planned to be treated with oxaliplatin-based chemotherapy as an adjuvant therapy or in the first or second line setting of advanced disease, age ≥18 years, ECOG performance score of 0-2, and internet access. A decision support tool consisting of a digital symptom monitoring, laboratory value interface, and treatment schedule integration for a semi-automatized chemotherapy cycle prescribing was created for the trial.

Results

The dataset included CRC patients (n=43) treated with doublet or triplet chemotherapy in adjuvant or metastatic setting, and 339 prescribed chemotherapy cycles. For the 77% of the new chemotherapy cycles, ePRO questionnaire data was available. 65% of cycles had symptom questionnaires grading at ≤ 1 while 67% of the cycles had laboratory values at pre-set range. The recommendation by the tool for a new chemotherapy cycle was (green/go) in 42.8%, two (yellow/evaluate) in 24.5%, and three (red/hold) 32.7% of the cycles. HCPs valued the improved workflow, faster patient evaluation, and direct messaging option the most.
Conclusions
In this study, we investigated the feasibility of a decision support system in chemotherapy cycle pre-evaluation and prescription. The study shows that the functionalities of the investigated tool were feasible, and an automated approach to chemotherapy cycle prescription was possible for nearly half of the cycles.
Trial registration: NCT04081558 9th Sep 2019
Effect of deoiled silkworm pupae meal (Bombyx mori) as a replacement of fish meal in the diet of juveniles of Silver pompano, Trachinotus blochii
Authors: S MithunKumar , J Jaculine Pereira , S Athithan , P Padmavathy , D Lingaprabu , KS Vijayamirtharaj 
Published: March 2023

Abstract
A ninety days growth trial and four weeks of digestibility study were conducted to evaluate the effect of replacing fish meal (FM) with deoiled silkworm pupae meal (DSWP) in the diet of juvenile silver pompano. Silver pompano seeds (0.93 ± 0.07 g) were randomly distributed into 15 FRP tanks (120 × 55 × 38cm) each consisting of 20 fish. Fish were fed thrice a day until apparent satiation with five experimental diets (RD, 25FMODSWP, 50FMODSWP, 75FMODSWP and 100 FMODSWP) which was prepared by replacing fishmeal at 0, 25, 50, 75 and 100% with DSWP respectively. The replacement of fishmeal with DSWP at 25% (p < 0.05) improved the final body weight, specific growth rate, feed conversion ratio and protein efficiency ratio. Apparent digestibility coefficient (ADCs) values of crude protein and fat was found to be higher in the RD and 25FMODSWP groups. Protease activity was significantly (p < 0.05) higher in fish fed the 25FMODSWP diet while amylase and lipase activities were higher in the 75FMODSWP and 100FMODSWP, respectively. The replacement of fishmeal by 75FMODSWP resulted in lower (p < 0.05) fat deposition in the whole-body tissue. The dietary inclusion of DSWP significantly (p < 0.05) improved overall blood profile until 50% FM protein replacement. The replacement of fishmeal with DSWP beyond 50% affects the intestinal structure due to necrotic lesions in the microvilli and detachment of surface epithelial cells from lamina propria. The results of this study suggested that DSWP can be used to replace 30.5% of FM protein which accounts 9.5% of SWP in the diet of silver pompano without any adverse effect on fish.
Resting energy expenditure, body composition, and metabolic alterations in breast cancer survivors vs. healthy controls: A cross-sectional study
Authors: Soom Timia Van , Tjalma Wiebren , Daele Ulrike Van , Gebruers Nick , Breda Eric van 
Published: March 2023

Abstract

Purpose:This study aimed to investigate the difference in absolute and relative measured resting energy expenditure (mREE) and body composition (body weight, fat mass (FM), fat free mass (FFM)) between breast cancer survivors (BCs) and controls. Correlations with body composition were analyzed. We examined if survival year, the metabolic state, or being metabolically dysfunctional were confounding factors.Methods:A cross-sectional analysis was conducted on 32 BCs ≤5years post treatment and 36 healthy controls. Indirect calorimetry measured absolute mREE. Body composition was determined by BOD POD. Relative mREE was calculated (absolute mREE/FFM). The Harris-Benedict equation was used to predict REE and determine the metabolic state (mREE/pREE). The database of the multidisciplinary breast clinic of the University Hospital of Antwerp was consulted for survival year and metabolic dysfunctions.Results:BCs have similar absolute mREE and greater relative mREE compared to controls with similar body composition. Absolute mREE and body composition between BCs differed; relative mREE was similar. FFM correlated significantly with absolute and relative mREE in BCs. A significant interaction term was found between survival year and FM for absolute mREE. The metabolic state was a significant contributor to absolute and relative mREE.Conclusion:BCs have similar or higher mREE. Differences in body composition between BCs are suggested to cause inter-individual variations in absolute mREE. We hypothesize that increased energy requirements are caused by metabolic stress related to cancer/treatment. Accurate measurement of REE and body composition is advised when adapting nutritional strategies, especially in patients at risk for developing metabolic dysfunctions.
Influence of Multi-source Data Analysis on Absolute Gravity Observations: Case Study of Jiufeng, Wuhan
Authors: Zhou Hao , Liu Ziwei , Zhang Xiaotong , Jiang Ying , Zhai Dulin , Chi Xiaozhuang 
Published: March 2023

Abstract
The influence of the background environment on absolute gravity values cannot be ignored. Based on multi-source data between 2013 and 2023 (including absolute gravity, Global Navigation Satellite System (GNSS) observation, underground fluid and rainfall, and vertical gravity gradient data), this paper calculated the influence of changes in the background environment on absolute gravity values and conducted linear fitting and analysis. The results indicated that the average annual rate of change in absolute gravity, underground fluid, and surface deformation at the Wuhan Jiufeng Seismic Station was − 0.1141 µGal/y, -0.5233m/y, and − 0.0016mm/y, respectively. Changes caused by various environmental factors were deducted from the measured absolute gravity values to obtain relatively reasonable and accurate absolute gravity values. Based on the research data and results, the trend of the underground movements of materials was analysed. This provides a theoretical basis for error correction and gravitational reference values for calibrating absolute gravity values at the Wuhan Jiufeng Seismic Station in the future.
Squamous cell carcinoma , serous adenocarcinoma and osteosarcoma arising in a mature cystic teratoma of the ovary: a case report and literature review
Authors: Huang Xiaoming , Liao Xuankai , Chen Xianwen , Zeng Zhouhong 
Published: March 2023

Abstract
Background
Malignant transformation of mature ovarian teratomas is a rare phenomenon, occurring mainly in postmenopausal women. Secondary malignancies may originate in either of the ectodermal, mesodermal and endodermal germ layers. Sarcomatous transformation is much less common than transformation into a malignant epithelial component. Cases of smooth muscle sarcoma, angiosarcoma, osteosarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma, and chondrosarcoma arising in mature ovarian teratomas have been described in the literature so far.
Case presentation
We report a case of squamous cell carcinoma, serous adenocarcinoma and osteosarcoma presenting in a mature ovarian teratoma in a 55-year-old woman. The presence of a mixture of the three tumour components in a background of typical dermatomal cysts, where the transition from normal squamous epithelium to squamous cell carcinoma was seen, is strong evidence that this particular tumour combination originated from an ovarian teratoma.
Conclusions
We report a rare tumour combination occurring in an ovarian teratoma and to date, to our knowledge, such a tumour combination should be described for the first time. More similar cases are needed to elucidate the biological pathways and underlying molecular mechanisms of these rare tumour combinations.
Causal Effects of Genetically Predicted Endometriosis on Breast cancer: A Two-Sample Mendelian Randomization Study
Authors: Yan Shuixin , Li Jiadi , Chen Jiafeng , Chen Yan , Qiu Yu , Zhou Yuxin , Wu Weizhu 
Published: March 2023

Abstract
This study used a Mendelian randomization (MR) approach to investigate the causal relationship between genetically predicted endometriosis (EMS) and breast cancer risk. A total of 122,977 cases and 105,974 controls were included in the analysis, with gene-level summary data obtained from the Breast Cancer Association Consortium. An inverse variance-weighting approach was applied to assess the causal relationship between EMS and breast cancer risk, and weighted median and MR-Egger regression methods were used to evaluate pleiotropy. Results showed a causal relationship between EMS and a decreased risk of overall breast cancer (odds ratio [OR] = 0.95; 95% CI 0.90–0.99, p = 0.02). Furthermore, EMS was associated with a lower risk for estrogen receptor (ER)-positive breast cancer in a subgroup analysis based on immunohistochemistry type (OR = 0.91; 95% CI 0.86–0.97, p = 0.005). However, there was no causal association between ER-negative breast cancer and survival (OR = 1.00; 95% CI 0.94–1.06, p = 0.89). Pleiotropy was not observed. These findings provide evidence of a relationship between EMS and reduced breast cancer risk in invasive breast cancer overall and specific tissue types, and support the results of a previous observational study. Further research is needed to elucidate the mechanisms underlying this association.
Diagnostic Accuracy of Abbreviated MRI Protocol (ABB-MRI) For Detection of Breast Cancer in Women With Dense Breast: A Systematic Review And Meta-Analysis
Authors: Parsaei Amirhossein , Karvane Houshang Bavandpour , Rahmani Alireza , Moradi Soroush , Amini Behnam , Hajighadery Abdolkarim , Dehghanbanadaki Hojat , Safari Roxana 
Published: March 2023

Abstract

Background
2D and 3D mammography are less accurate than MRI for breast cancer diagnosis. ABB-MRI is a solution to the constraints of full diagnostic protocol MRI (FDP-MRI). This study synthesizes the evidence on the diagnostic effectiveness of ABB-MRI for screening women with dense breast tissue.
Methods
Using PRISMA guidelines, we conducted a systematic review and meta-analysis on multiple databases in August 2022. This review included studies that enrolled women with dense breast for screening, evaluated the diagnostic accuracy of ABB-MRI, and included a reference standard (histopathology). Students with all risk evaluation categories (mixed risk) were included in the study. We assessed the quality of included studies using QUADAS-2 in terms of bias concerns and applicability concerns. We synthesized the data by using a bivariate random-effects model and characterized overall values with forest plots. ABB-MRI performance was shown in the analysis with a 95% confidence region using a SROC plot. In a ROC analysis, the average true positive rate over a range of false positives was calculated.
Results
After reviewing 25 articles, 7 studies were included for quality assessment and quantitative analysis. In terms of bias and applicability, all studies exhibited low-risk. The meta-analysis includes 7 studies (plus one reader) that compared the sensitivity and specificity of an abbreviated MRI protocol (index test) to histology or follow-up. The pooled overall accuracy values of ABB-MRI for all included studies were sensitivity = 0.96 [0.91– 0.98] and specificity = 0.88 [0.85–0.91]. The SROC curve indicated an area under the curve (AUC) of 0.98 [0.96–0.99].
Conclusions
Abbreviated Breast MRI Protocol (ABB-MRI) provides good specificity and sensitivity for identifying breast lesions in women with dense breasts. More research is needed to answer the broader questions raised by this study about the efficacy, safety, cost, and practicality of using this technique among this population.
A MMFF94 study of the structure and interactions of ocular solutions containing hyaluronic acid with collagen models
Authors: Ikeora Obinna Chiedozie , Joseph Simi Sabu , Zeinalipour-Yazdi Constantinos D. 
Published: March 2023

Abstract
Molecular modelling techniques have been widely used in drug discovery fields for rational drug design and compound screening. They have however not been used extensively to understand the mechanism of action of drugs within the human body. In this computational study we have used molecular mechanics modelling to describe a complicated biochemical system that exists in the human eye and to describe the mechanism of action of hyaluronic acid in hydrating the collagen from which the cornea of the eyes are made of. Our studies include atomistic level details about what kind of interactions water has with hyaluronic acid and collagen and in systems containing both hyaluronic acid and collagen models. We observe that water has a greater binding energy to collagen than to hyaluronic acid and that hyaluronic acid binds to collagen via H-bonding and maintains its ability to become hydrated with water based on energetic considerations of the binding energy of water with these biomolecules. The study demonstrates the mechanism of action of hyaluronic acid hydration in the human eye which can be used as model system to study the hydrating effect of other ocular solutions based on the quantitative determination of the binding energy of water with these biological molecules.
Endothelial dysfunction is associated with reduced myocardial mechano-energetic efficiency in drug-naïve hypertensive individuals with a broad spectrum of glucose tolerance
Authors: Cefalo Chiara M. A. , Riccio Alessia , Fiorentino Teresa Vanessa , Rubino Mariangela , Massimino Mattia , Mannino Gaia Chiara , Succurro Elena , Perticone Maria , Sciacqua Angela , Andreozzi Francesco , Sesti Giorgio 
Published: March 2023

Abstract

Background:Impaired myocardial mechano-energetics efficiency (MEEi) was shown to predict incident heart failure, but pathophysiological mechanisms linking impaired MEEi with heart failure have not been elucidated. Endothelial dysfunction is a plausible candidate because it has been associated with heart failure. This study aims to investigate the association between MEEi and endothelium‐dependent vasodilation, among drug-naïve hypertensive individuals with a broad spectrum of glucose tolerance.Methods:199 drug-naïve hypertensive individuals participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study were included. All participants underwent to an oral glucose tolerance test and to an echocardiogram for myocardial MEEi measurement. Endothelial-dependent and endothelial-independent vasodilatation were measured by strain-gauge plethysmography during intra-arterial infusion of acetylcholine and sodium nitroprusside, respectively. A multivariate linear regression analysis was conducted to investigate the independent association between endothelial-dependent vasodilation and MEEi.Results:ACh-stimulated forearm blood flow (FBF) was associated to decreased myocardial MEEi at all the three doses tested: 7.5, 15, and 30 µg/mL-1 x min-1 (β =0.201, P=0.002; β =0.171, P=0.008; β =0.205, P=0.002 respectively) independently of well‐established cardiovascular risk factorsincluding age, sex, BMI, waist circumference, smoking status, total and HDL cholesterol, triglyceride, hsCRP, glucose tolerance status, and HOMA-IR index of insulin resistance. No association was observed between SNP-stimulated vasodilation and MEEi.Conclusions:We found that endothelium-mediated vasodilation contributed to reduced myocardial MEEi independently of several potential confounders. Because diminished myocardial MEE has been associated with incident heart failure, assessment of myocardial MEEi may improve the identification of individuals at risk of heart failure requiring a closer follow-up.
The stratification and invariant region of chaotic sea in an area-preserving Lozi map
Authors: Li Bo , Gu En-Guo 
Published: March 2023

Abstract
In this paper, we study the hierarchical structure of a chaotic sea and the existence condition and delimitation method of island chain for Lozi map. The regular island chains associated with elliptic periodic points in chaotic sea are investigated by the theory presented in [15]. A method for determining the boundaries of the island chain is introduced. Multiple layers of a chaotic sea are found which are dependent on initial values. A method of determining the layer boundary of chaotic sea is presented. We found that critical line plays an important role in determining the boundaries of the layer of chaotic sea. We also prove that all trajectories are symmetric with respect to the diagonal dividing line of the second and fourth quadrants.
Pooled analysis of diagnostic performance of the instrument-read Quidel Sofia SARS antigen Fluorescent Immunoassay (FIA)
Authors: Lippi Giuseppe , Henry Brandon M. , Plebani Mario 
Published: March 2023

Abstract
Background. This article presents a critical literature review and meta-analysis of diagnostic performance of Quidel Sofia SARS antigen Fluorescent Immunoassay (FIA), a rapid diagnostic antigen test (RDT-Ag) adapted for automatic reading with portable instruments, thus potentially combining the advantages of point-of-care testing with those of a laboratory-based immunoassay.
Methods: We conduced an electronic search in PubMed and Scopus with the keywords "Quidel" OR “SOFIA” AND “Antigen” AND "SARS-CoV-2" OR “COVID-19” up to March 24, 2023, for identifying articles containing data on accuracy of Quidel Sofia SARS antigen FIA for diagnosing acute SARS-CoV-2 infections. We selected those where test accuracy was compared to that of a reference SARS-CoV-2 molecular assay, and with sufficient information for constructing a 2×2 table.
Results: A total number of 18 articles (48165 samples; 9.8% positive at molecular testing) were included in this meta-analysis, averaging 24 sample cohorts. The diagnostic accuracy (summary area under the curve), sensitivity and specificity were 0.980, 0.76 and 1.00 in all samples, 0.981, 0.81 and 0.99 in samples collected from symptomatic patients, 0.931, 0.55 and 1.00 in those taken from asymptomatic patients, and 0.960, 0.77 and 0.99 in samples from mixed cohorts of patients, respectively. Minor and clinically negligible differences of accuracy could be found by comparing test results in nasal and nasopharyngeal swabs.
Conclusion: Quidel Sofia SARS Ag FIA meets the minimum performance criteria of accuracy for SARS-CoV-2 antigenic testing, thus combining satisfactory diagnostic performance with the advantages of being potentially used as a portable device.
Structural classification of boron nitride twisted bilayers and ab initio investigation of their stacking-dependent electronic structure
Authors: Latil Sylvain , Amara Hakim , Sponza Lorenzo 
Published: March 2023

Since the discovery of superconductive twisted bilayer graphene which
initiated the field of twistronics, moiré systems have not ceased to
exhibit fascinating properties. We demonstrate that in boron nitride
twisted bilayers, for a given moiré periodicity, there are five
different stackings which preserve the monolayer hexagonal symmetry
(i.e. the invariance upon rotations of 120°)
and not only two as always discussed in literature. We introduce some
definitions and a nomenclature that identify unambiguously the twist
angle and the stacking sequence of any hexagonal bilayer with order-3
rotation symmetry. Moreover, we employ density functional theory to
study the evolution of the band structure as a function of the twist
angle for each of the five stacking sequences of boron nitride bilayers.
We show that the gap is indirect at any angle and in any stacking, and
identify features that are conserved within the same stacking sequence
irrespective of the angle of twist.
Mobile Acceptance and Commitment Therapy With Distressed First-Generation College Students: Microrandomized Trial
Authors: Thomas Emily Brenny Kroska , Sagorac Gruichich Tijana , Maronge Jacob M , Hoel Sydney , Victory Amanda , Stowe Zachary N , Cochran Amy 
Published: March 2023

Background
Extant gaps in mental health services are intensified among first-generation college students. Improving access to empirically based interventions is critical, and mobile health (mHealth) interventions are growing in support. Acceptance and commitment therapy (ACT) is an empirically supported intervention that has been applied to college students, via mobile app, and in brief intervals.

Objective
This study evaluated the safety, feasibility, and effectiveness of an ACT-based mHealth intervention using a microrandomized trial (MRT) design.

Methods
Participants (N=34) were 18- to 19-year-old first-generation college students reporting distress, who participated in a 6-week intervention period of twice-daily assessments and randomization to intervention. Participants logged symptoms, moods, and behaviors on the mobile app Lorevimo. After the assessment, participants were randomized to an ACT-based intervention or no intervention. Analyses examined proximal change after randomization using a weighted and centered least squares approach. Outcomes included values-based and avoidance behavior, as well as depressive symptoms and perceived stress.

Results
The findings indicated the intervention was safe and feasible. The intervention increased values-based behavior but did not decrease avoidance behavior. The intervention reduced depressive symptoms but not perceived stress.

Conclusions
An MRT of an mHealth ACT-based intervention among distressed first-generation college students suggests that a larger MRT is warranted. Future investigations may tailor interventions to contexts where intervention is most impactful.

Trial Registration
ClinicalTrials.gov NCT04081662; https://clinicaltrials.gov/show/NCT04081662

International Registered Report Identifier (IRRID)
RR2-10.2196/17086