bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estandarización de la batería de Evaluación de la Memoria Semántica (EMSEA) en adultos mayores institucionalizados de Lima
Authors: Livia-Segovia José , Grasso Lina , Herrera-Pino Agnes Daniel , Ortiz-Morán Mafalda , Benavides-Munarriz Nicolle 
Published: April 2023

Objective: To determine if semantic memory is a factor associated with cognitive impairment in older adults in Lima. Method: The Semantic Memory Assessment Battery for Older Adults (EMSEA), the Mini-mental State Examination (MMSE) and other instruments that were used as external criteria were applied. The sample consisted of 158 older adults from Metropolitan Lima between 60 and 95 years of age. EMSEA differentiates between a normal and clinical sample, with a sensitivity of 80% and a specificity of 100% for a cut-off point of 251. Concurrent validity is evidenced and a two-factor EMSEA model is demonstrated. Cronbach's Alpha value is .75 and Theta is .80. Results: Descriptive data indicated a 28% prevalence of cognitive impairment and a 23% low semantic memory level. The predictive model indicates that three areas of semantic memory are associated with cognitive impairment with an R2 of 25%, leaving the model established by: Verification, naming of drawings and analogies. Conclusion: It is concluded that the EMSEA battery presents evidence of criterion and construct validity, internal consistency and a predictive.
Objetivo: Determinar si la memoria semántica es un factor asociado al deterioro cognitivo en adultos mayores de Lima. Método: Se aplicaron la batería de Evaluación de la Memoria Semántica para Adultos Mayores (EMSEA), el Mini-mental State Examination (MMSE) y otros instrumentos que fueron utilizados como criterios externos. La muestra estuvo constituida por 158 adultos mayores de Lima Metropolitana entre 60 a 95 años de edad. La EMSEA diferencia entre una muestra normal y clínica, siendo la sensibilidad de 80% y la especificidad de 100% para un punto de corte de 251. Se evidencia validez concurrente y se demuestra un modelo EMSEA de dos factores. La confiabilidad fue adecuada con valor Alfa de Cronbach de .75 y Theta de .80. Resultados: Los datos descriptivos señalaron un 28% de prevalencia de deterioro cognitivo y 23% de nivel de memoria semántica bajo. El modelo predictivo señala que tres áreas de la memoria semántica están asociadas al deterioro cognitivo con un R2 de 25%, quedando el modelo establecido por: Verificación, denominación de dibujos y analogías. Conclusión: Se concluye que la batería EMSEA presenta evidencia de validez de criterio y constructo, así como consistencia interna.
The most unmet needs on Gynecological and Breast Cancer Survivors, A Systematic Review
Authors: Nasution Lina Anisa , Afiyanti Yati , Ma'rifah Atun Raudotul 
Published: April 2023

Introduction: The complexity of treating gynecological and breast cancer causes unmet needs for survivors. This systematic review aimed to identify the most unmet needs of gynecological and breast cancer survivors from the available evidence. Method: Researchers searched the electronic databases PubMed, Cochrane, CINAHL, Ebsco Host, and Science Direct with predetermined criteria. The keywords used were combinations of "gynaecologic* cancer" OR "gynaecologic* cancer survivors" OR "breast cancer" OR "breast cancer survivors" AND "unmet needs." A systematic review was made using PRISMA, the critical appraisal was carried out with the JBI instrument, and bias analysis was carried out using the Robvis Tool. Results: There are 12 selected articles. The two highest unmet needs domains for gynecological and breast cancer survivors are the health system information and psychological domains. Conclusions: Nurses and other health workers must pay attention to implementing holistic care to meet the various needs of gynecological cancer survivors, including health system information and psychological domains.
Introduccion: La complejidad del tratamiento del cancer ginecológico y de mama genera necesidades insatisfechas para los sobrevivientes. Esta revisión sistemática tuvo como objetivo identificar las necesidades más insatisfechas de las sobrevivientes de cancer ginecológico y de mama a partir de la evidencia disponible.Método: Los investigadores realizaron búsquedas en las bases de datos PubMed, Cochrane, CINAHL, Ebsco Host, Science Direct con criterios electrónicos predeterminados. Las palabras claves usadas fueron combinacion de " cáncer " ginecológico *"O" sobrevivientes de cáncer ginecológico *" O " cáncer de mama" O " sobrevivientes de cáncer de mama" Y " necesidades insatisfechas ". Se realizó una revisión sistemática mediante PRISMA, la evaluación crítica se realizó con el instrumento JBI y el análisis de sesiones mediante la herramienta Robvis.Resultados: Hay 12 artículos seleccionados. Los dos dominios de necesidades insatisfechas más importantes para los sobrevivientes de cáncer ginecológico y cáncer de mama son el dominio de informacion del sistema de salud y el dominio psicológico.Conclusión: Las enfermeras y otros trabajadores de la salud deben prestar atencion a la implementacion de una atención holística para satisfacer las diversas necesidades de los sobrevivientes de cancer ginecológico, incluidas las necesidades de información del sistema de salud y los dominios psicológicos.
Malawian critical care nurses’ views on the implementation of an educational intervention to enhance sustained use of an evidence-based endotracheal tube cuff pressure management guideline: A survey study
Authors: Mpasa F , Van Rooyen D R M , Jordan P J , Venter D , Ten Ham-Baloyi W 
Published: April 2023

Background. Evidence-based guidelines can assist critical care nurses in promoting best practices, including those related to endotracheal tube cuff pressure management. However, these guidelines require tailored strategies to enhance their implementation, uptake, and sustained use in practice.
Objectives. To evaluate Malawian critical care nurses’ views on the implementation of an endotracheal tube cuff pressure management guideline to enhance sustained guideline use.
Methods. An explorative-descriptive survey design was employed, using a questionnaire with closed- and open-ended questions that was distributed after implementation of an educational intervention based on an endotracheal tube cuff pressure management guideline. The questionnaire had a Cronbach’s alpha score of 0.85.
Results. A total of 47 nurses working in four public and two private hospital intensive care units in Malawi participated. Quantitative findings showed that the majority of the participants (92%) indicated that the strategies used for the group that received the full intervention including both active (monitoring visits) and passive (a half-day educational session using a PowerPoint presentation, and a printed guideline and algorithm) strategies (intervention 1 group) were useful, clear and applicable and enhanced implementation of the guideline. These results were statistically significant (mean (standard deviation) 1.86 (0.84); t=6.07; p<0.0005). Qualitative data revealed three major themes related to recommendations for uptake and sustained use of the guideline in nursing practice: the guideline needs to be translated, updated, and made available to ICU staff; implementation strategies (continuous supervision and follow-up); and facilitating factors for successful implementation (education and training on guideline content, resources, and commitment to best practices).
Conclusion. The study highlighted that although the implementation strategies used were positively received by participants, they need to be further tailored to their context to enhance guideline uptake and sustained use in practice. Further study is required to ensure that tailored implementation strategies facilitate guideline uptake and sustained use, specifically in resource-constrained contexts.
Microsatellite markers-aided dissection of iron, zinc and cadmium accumulation potential in Triticum aestivum
Authors: Rasheed Asima , Ahmad Javed , Nadeem Majid , Rashid Muhammad Abdul Rehman , Azeem Farrukh 
Published: April 2023

Background
Wheat is a staple cereal food around the globe. It provides a significant source of proteins, carbohydrates, and other micronutrients to humans. When grown on cadmium (Cd) contaminated soils, the uptake of trace elements e.g., iron (Fe) and zinc (Zn) has also been affected drastically that in turn affected the wheat grain.

Methods
In this study, wheat accessions were used to investigate the impact of soil application of Zn (5 mg/kg, 20 mg/kg) and Cd (0 mg/kg, 10 mg/kg) on accumulation of these elements in wheat grains. A total of 45 Fe, Zn, and Cd transporter-related genes were used to design 101 gene-specific SSR (simple sequence repeat) markers.

Results
In response to Cd stress, application of 20 mg/Kg Zn improved Fe (64.6 ug/g) and Zn (48.3 ug/g) accumulation in wheat grains as well as agronomic traits. Marker trait association revealed that SSR markers based on NAM-B1 gene (PR01 and PR02) were associated with Zn accumulation. Similarly, SSR markers based on TaVTL5-2B_5 (PR19 PR20), TaVTL5-2B_2 (PR25, PR26), TaVTL5-2D_3 (PR30), TaVTL2-2A (PR31), TaVTL1-6A (PR32), and TaVTL2-2D_1 (PR37) were significantly associated with Fe accumulation, while HMA3-5B1 (PR62) and TaNRAMP3-7D (PR89) were linked to Cd accumulation in grains. The highly associated markers may be used in marker-assisted selection of suitable wheat genotypes for breeding bio-fortified varieties with low Cd accumulation.
Electron Transfer Reaction of Theobromine and Permanganate Ion in Aqueous Acidic Media
Authors: Jones Frank , Anweting Idongesit Bassey , Okon Idongesit  Edem 
Published: April 2023

Electron transfer reaction of theobromine (hereafter referred to as TB) and permanganate ion has been studied using spectrophotometric technique under pseudo first-order conditions at T = 24, [H+] = 3.2 × 10–1 mol dm–3and I = 1.0 mol dm–3 (Na2SO4). Stoichiometric study depicted that two moles of TB were consumed by one mole of permanganate ion. The rate of the reaction is first order in both [TB] and [MnO4-] and second order overall. It was observed that, [H+] and ionic strength respectively enhanced the rate of the reaction in the range studied. Michaelis-Mentens analysis showed no evidence of intermediate complex formation. Added anions and cations were observed to catalyze the reaction rate. The reaction conforms to the rate law as shown below:

-d [MnO4-]/dt = (a+b [H+]) [TB] [MnO4-]
where a = 0.041 dm3mol–1 s–1 and b= 0.028 dm3mol–1 s–1.
The reaction thus occurs by an outer-sphere pathway and plausible mechanism is proposed for the reaction.
Factors that Influence the Buying Behaviour of Ready to Eat Food Products
Authors: Satnam  , Kumar Amit , Dwivedi Pritesh , Singh Vinaypal , Siwach Anshu 
Published: April 2023

The present investigated was conducted at Dadri, Gautam Buddh Nagar, UP. Out of 50 respondents this data has been collected from research area. 13% people opinion is about RTE food is easily available now days in the market. 14% consumers purchase the food on the basis of their taste. About 8% people buying that food because their family preferand like the ready to eat food and 1% people are those who are buying that food to influence by other and 10% also those were convenient from other users. Mostly around 15% consumers were those always buying consuming the RTE food for saving their cooking and preparation time. In the end rest 0% people nil due to the no data.
On the other hand, there were few respondents out of 100% those have valid reason based on their past consumption experience to purchase ready to eat (RTE) food. Firstly, there was around 4% people those were unable to buy RTE food due to the lack of their awareness and knowledge also. Approximately 6% consumers were those who dislike the RTE products due to any valid reason. Around 26% people were not able to buy the RTE food products due to the high price of product. Nearby 20% consumers dislike the products due their low quality.
4% consumers were unable to buy the RTE food products due to the unavailability. Approximately 34% people dislike the products because according to them, Ready to Eat food are too much health conscious because those are available in the form of extra fat, extra fibers, etc. Less than 6% consumers are those who haven’t any valid reason to buy RTE food products.
An Application of ARIMAX Model to Examine the Effect of Climatic Factors on the Annual rice Production in Bangladesh
Authors: Islam Md. Roshidul , Chowdhury Arman Hossain 
Published: April 2023

Rice is the world’s third main crops and around 160 million of people in Bangladesh consume it as a staple food. As a climate vulnerable country, the effect of climatic factors on rice production in Bangladesh is noticeable. Therefore, the study aimed to examine the impact of climatic factors on annual rice production in Bangladesh. We compiled a yearly dataset including rice production, mean temperature (˚C), relative humidity (%) and precipitation (mm/day) from 1981 to 2020. The entire data were analyzed by using Autoregressive Integrated Moving Average with Explanatory Variables (ARIMAX) model. We found that mean temperature had a negative impact on the rice production (β = -13518243, 95% CI: -19868503, -7167982). Relative humidity had both positive impact on the rice production (β = 1824456, 95% CI: 418585, 2230327). Precipitation had both positive and negative impact on the rice production. In conclusion, mean temperature, relative humidity, and precipitation are three factors that may have an influence on the annual rice production in Bangladesh. Since Bangladesh has a hot, humid environment, it is therefore advised that breeders create rice types that use less water and are more effective in high temperatures.
Evaluation of the Efficacy of Herbal Antidotes of Viper Snakes through In-silico Docking Analysis of their Bioactive Components Targeting Phospholipase A2
Authors: Adithya R. Sathish , Kanimozhi S. 
Published: April 2023

Introduction: Snake bite is common in Rural areas. Many toxic snakes produce neurotoxic, Myotoxic, and hemotoxic effects. Snake venom is rich in metalloproteinases and Phospholipases. PhospholipaseA2 accounts for most of the toxic effects of Viper snakes. Many herbal antidotes have been in practice in the Siddha system which lacks scientific evidence.
Aim: This study aims to rule out the Binding pose and affinity of bioactive components derived from certain herbs with the target by forming hydrogen bonds so that the function of Phospholipases A2 with PDB – 2QOG would be hindered.
Materials and Methods: From the listed plants 6 bioactive components were selected and In-Siico docking analysis was done with the target2QOG. Andrographolide (49 ASP, 52 TYR), Aristolochic acid(49 ASP, 52 TYR), Genistein(49 ASP, 52 TYR), and Nimbolide (49 ASP, 52 TYR) revealed a maximum of 2 interactions (50%) with the core active amino acid residues present on the target2QOG. Piperic acid (48 HIS) and Linoleic acid(48 HIS) reveal 1 interaction with the core active amino acid residues present on the target 2QOG.
Conclusion: Based on the results it was concluded that the bio-active compounds Andrographolide, Aristolochic acid, and Genistein present in the herbal ingredients possess significant binding against the target enzyme phospholipases A2.
Effect of Mulching on Growth, Yield and Quality Attributes of (Fragaria x ananassa) in Dehradun Valley of Uttarakhand
Authors: Semwal Ankit , Nautiyal Pankaj , Arora Indu , Dongariyal Ankit , Pandey Shivangi , Thaledi Damini 
Published: April 2023

The Present experimental research was conducted during the year 2020-21 at Horticulture Research block, School of Agriculture Sciences, SGRR University, Dehradun, Uttarakhand to study the “Effect of Mulching on Growth, Yield and Quality Attributes of Strawberry (Fragaria X ananassa) in Dehradun Valley of Uttarakhand”. The field experiment was laid out in randomized block design with three replications and three treatments. The treatments were comprised with different mulching materials viz. control as without mulching (T1), straw mulching (T2) and Polythene mulching (T3). The planting of cultivar “Chandler” was done on first week of November, 2020 and observations were recorded at 30 DAT, 60 DAT, 90 DAT, 120 DAT, and 150 DAT and at final harvest. Significant results were obtained for different attributes of growth, yield, and quality as well as in terms of economics under the treatment of black polythene mulching (T3). The results showed that the Number of Flowers per Plant (24.08), Plant spread (48.06 cm), Fruit length (4.22 cm), Fruit diameter (3.80 cm), Fruit texture (5.9 lb), T.S.S. (8.92 0Brix) and Total juice content (84.05 %) However, the control (T1) reported maximum Titrable acidity (0.92 %).
Spontaneous Intraperitoneal Rupture of Hydatid Cysts of the Liver with Encapsulating Peritonitis: A Case Report
Authors: Jbilou Aymane , Aggouri Younes , Tarif Badr , Ahallat Anass , Aitlaalim Said 
Published: April 2023

Background: Spontaneous rupture of a hepatic hydatid cyst resulting in biliary peritonitis is an infrequent but severe complication that requires urgent surgical intervention and has high rates of morbidity and mortality. There are very few reported cases of this complication in the medical literature.
Case Presentation: We present an unusual case of a 64-year-old male who presented with acute peritonitis due to biliary peritonitis resulting from the spontaneous rupture of a large hydatid cyst of the liver, as seen on contrast-enhanced computed tomography, which also showed intraperitoneal fluid. During the operation, approximately 4L of infected bile was found in the peritoneal cavity, and a cystobiliary communication was observed with rupture of the anterior wall of the cyst. Treatment involved unroofing the cyst and closing the communication. The patient was free of recurrence and in good health after 6 months of follow-up.
Conclusion: Although this complication is rare, it should be considered in the differential diagnosis of acute abdominal pain in patients living in endemic areas.
Effect of Plant Growth Regulator and Micronutrient on Growth, Flowering, and Physical Quality Parameters of Litchi (Litchi chinensis Sonn.) cv. Dehradun
Authors: Nand Viveka , Dwivedi A. K. , Tripathi V. K. 
Published: April 2023

The experiment was carried out at Horticulture Garden, Department of Fruit Science, Chandra Shekhar Azad University of Agriculture & Technology, Kanpur (U.P.) during two subsequent years i.e., 2020 and 2021. Sixteen treatments viz., four levels of GA (0, 20, 40 and 60 ppm) and Zn (0, 0.3, 0.5 and 0.7%) were studied in a Factorial Completely Randomized Design with three replications. Spraying was done twice i.e., before flowering (07 Feb.) and at pea stage (05 April) during both the years. Application of GA 60 ppm and Zinc 0.7% increases length of new shoot (24.41 and 24.44 cm), number of leaves per shoot (23.55 and 24.06), length of panicle (34.89 and 35.96 cm), number of fruit per panicle (21.11 and 22.19), length of fruit (4.21 and 4.30 cm), diameter of fruit (4.22 and 4.29 cm), fruit weight (20.22 and 21.16 g), weight of pulp (13.69 and 13.70 g), and pulp stone ratio (4.65 and 4.62) in both respective years and reduced days required to flowering after first spray (22.13 and 21.30) days, length of seed (2.16 and 2.14 cm), diameter of seed (1.32 and 1.30 cm), weight of seed (3.20 and 3.17 g) and rind weight (2.54 and 2.52 g). We suggest that the foliar application of GA (60ppm) and Zn (0.7%) may be included in strawberry farming for profitable yields and high GA and Zn concentration in strawberry fruit in the plains of Northern India.
Efficacy of Localised Application of Tranexemic Acid and Mefenamic Acid Tablet Powder in Extraction Sockets for Control of Post Extraction Bleeding and Pain in Dental Practise
Authors: Devika J. , Sequeira Joyce P. 
Published: April 2023

Background: Post extraction bleeding and pain are two common complications in routine dental practice .There are no studies in which Tranexamic acid and Mefenamic acid combination powder is used locally to control post extraction bleeding and pain.
Methodology: This study was conducted in 18 patients indicated for orthodontic extraction of mandibular first premolar and right side was the study side in which pre crushed TRANSET MF powder was placed and compared to the left side which was the control side .Post extraction bleeding immediately and 30 min post extraction was compared along with pain using VAS pain scale on 1,2,3,7 th day post extraction.
Results: There was statistically significant difference in time of post extraction bleeding between study side (less time) and the control side .There is statistically significant difference in pain scale; less pain perceived in the study side than the control side.
Conclusion: This study is the first one to evaluate the efficacy of crushed TRANSET MF Tablet Powder in post extraction sockets and has shown significant results in reducing post extraction pain and bleeding with no local and systemic side effects .Hence this will be a simple and cost effective technique that can reduce both post extraction bleeding and pain.
NGF‐mediated alteration of NF‐κB binding activity after partial immunolesions to rat cholinergic basal forebrain neurons
Authors: Gu Zezong , Toliver‐Kinsky Tracy , Glasgow Joel , Werrbach‐Perez Karin , Perez‐Polo J. Regino 
Published: July 2002

AbstractThere are age‐associated cognitive and cholinergic deficits in the neurotrophin‐dependent cholinergic basal forebrain neurons (CBFNs). There are also increases in the activity of the transcription factor NF‐κB in the aged rodent brain that may reflect chronic enhancement of stress response signaling. We used partial immunolesions (PIL) to CBFN to examine the role of endogenous NGF on choline acetyltransferase (ChAT) activity and NGF‐mediated NF‐κB alteration after cholinergic deafferentation. We injected 192 IgG‐saporin, an immunotoxin selectively taken up by neurotrophin receptor p75NTR‐bearing neurons, into lateral ventricles, followed by infusions of anti‐NGF to assess NF‐κB, ChAT and NGF responses to PIL after anti‐NGF infusion. Treatment with anti‐NGF decreased ChAT activity by 17–34% in the cortex, hippocampus, and olfactory bulb and PIL decreased ChAT activity by 47–73%. Changes in AChE activity levels paralleled those observed for ChAT after PIL. NGF protein levels in the olfactory bulb, but not the cortex or hippocampus, increased significantly after PIL treatment. Infusion of anti‐NGF abolished the PIL‐induced eight‐fold NGF increase in CNS. NF‐κB binding activity to the IgG‐κB and ChAT specific NF‐κB consensus sequences, increased in the cortex but not hippocampus after PIL followed by anti‐NGF infusion. It is likely that immunolesion‐induced changes in ambient NGF levels may perturb NF‐κB activity.
Design of a Molecular Chaperone‐Assisted Protein Folding Bioreactor
Authors: Kohler Reto J. , Preuss Monika , Miller Andrew D. 
Published: July 2002

AbstractEscherichia coli molecular chaperone GroEL and co‐chaperone GroES are well known to assist the folding/refolding of a diverse range of substrate proteins. Despite this, there have been relatively few reports of the GroEL/GroES molecular chaperone system being used as a biotechnology tool for protein folding/refolding. In this paper, a solution‐phase protein folding bioreactor is described that involves the complete GroEL/GroES system. The main features of this bioreactor are the use of a stirred‐cell concentrator fitted with a 100 kDa molecular weight cutoff membrane and an attached buffer reservoir. This bioreactor system was used successfully for assisted‐batch refolding of guanidinium chloride (Gu‐HCl) unfolded mitochondrial malate dehydrogenase (mMDH). We believe that protein folding bioreactor systems of this type could have wide potential utility for the folding/refolding of unfolded protein substrates.