bluuebunny/crossref_metadata_2025_split huggingface dataset:
First Incidence of Parietal Lobe Metastasis in an Adult with Desmoplastic/Nodular Medulloblastoma: A Case Report and Review of the Literature
Authors: Zaresharifi Nooshin , Abbaspour Elahe , Yousefzade-Chabok Shahrokh , Reihanian Zoheir , Karimian Paridokht , Karimzadhagh Sahand 
Published: September 2023

Abstract
Background: Medulloblastoma in adults is a rare and highly aggressive central nervous system (CNS) tumor, representing less than 1% of all brain tumors. Supratentorial metastasis is uncommon, and extraneural metastasis occurs in approximately 5% of cases, primarily in frontal and temporal lobes. Here, we present a unique case of parietal lobe metastasis in an adult with desmoplastic/nodular medulloblastoma, adding a novel dimension to the existing knowledge base. We conducted a thorough search on the PubMed database to explore prior cases and establish the uniqueness of our case.
Case presentation: A 46-year-old male with a posterior fossa tumor and hydrocephalus was diagnosed with medulloblastoma seven years ago. Adjuvant concurrent chemoradiotherapy was administered after surgery. After five years, a surveillance brain MRI suggested possible tumor recurrence. A whole-body bone scan revealed widespread bone marrow metastases. Despite receiving adjuvant therapy in the past two years, the patient has experienced progressive right hemiparesis, ataxia, and gait disturbances. A brain MRI showed a distinct 6 x 4 x 2 cm in the left parietal lobe. The patient's tumor was entirely removed, initially suspected to be a parasagittal meningioma. However, it was identified as a supratentorial metastasis of desmoplastic/nodular medulloblastoma after a thorough histopathological examination.
Conclusion: Considering the possibility of tumor recurrence or intracranial metastasis in medulloblastoma patients is crucial. Regular treatments and follow-ups are strongly recommended to detect any signs of reoccurrence in these atypical presentations promptly.
The pathogenesis of Acute Exogenous Lipid Pneumonia based on proteomics
Authors: Weng Tingting , Wang Huamin , Xu Zijing , Liang Dongshi , Huang Airong , Ye Wanding , Hu Xiaoguang , Xu Zhiwei , Jin YiMei 
Published: September 2023

Abstract
Introduction
Acute exogenous lipoid pneumonia (AELP) is a rare disease. At present, the specific pathogenesis of AELP is unclear, and there is no safe and effective specific drug. The purpose of this study is to explore the biological processes, signal pathways and key proteins involved in AELP through proteomics, bioinformatics and polymerase chain reaction, so as to deepen the study of the pathogenesis of AELP.
Methods
The experimental rats were randomly divided into 2 groups: experiment group (inhaled 0.5 ml/kg of sewing machine oil) and control group (inhaled 0.5 ml/kg of normal saline). Collect the proteins in the upper lobe of the right lung of mice for proteomic sequencing to obtain the expression data, use the differential analysis software MaxQuant to screen the differentially expressed proteins (DEPs), and use the bioinformatics analysis method to carry out gene ontology function (GO), Kyoto Encyclopedia of genes and genomes (KEGG) analysis and protein-protein interaction (PPI) network construction for DEGs, Eleven key proteins (PADI4, IGF2, SMPDL3B, UHRF1, ANXA8, DEFB4, F3, MK167, SLC39A4, LIMD1 and GJA1) were detected by Reverse-transcription polymerase chain reaction (RT-PCR) for validation.
Results
A total of 1253 DEPs were obtained after comparing the data of the experimental group and the control group with the proteome, including 843 up-regulated proteins and 410 down-regulated proteins. Through the functional analysis of GO and KEGG, it is found that these DEPs mainly participate in the regulation process of integrin binding, proteoglycan binding, chemokine receptor binding, receiver regulator binding, and cytokine activity, and are significantly enriched in proteoglycan binding and other signal pathways. PPI network construction was carried out for DEPs to screen out proteins with high correlation, such as ACTN3, CX3CR1, CCR3, AGT, MYLPF. 11 proteins were verified by RT-PCR，compared with the control group, 9 proteins (PADI4, IGF2, SMPDL3B, UHRF1, ANXA8, MK167, SLC39A4, LIMD1 and GJA1) were significantly up-regulated in the experimental group.
Conclusion
Our findings identified that PADI4, IGF2, UHRF1, DEFB4 and GJA1 proteins may be potential diagnostic biomarker of AELP.
Inequality, Diversity, Institutions and Social Cohesion: Unveiling the Importance of Access to Opportunities
Authors: Akram Shahla , Perviaz Zahid 
Published: September 2023

Abstract

This study explores the complex relationship between inequality of opportunities, institutions, and social cohesion. Existing literature is employed to assess the influence of access to opportunities in forming social cohesion, taking into account factors of inequality such as economic class, gender, geography, political affiliation, and social group membership. Regression models and panel data analysis are used to quantify the impacts of different varieties of inequality on social cohesion. Results of the study demonstrate the negative effects of inequality of opportunities on social cohesion, thus reinforcing the importance of tackling inequality to create a more harmonious society. The limitations of the study are discussed, in addition to avenues for further research, and policy implications are elucidated, with a focus on the importance of implementing measures counteracting inequality and encouraging equitable access to opportunities in order to augment social cohesion. This study contributes important insights into the integration of inequality, institutions, and social cohesion, providing policymakers and stakeholders with a comprehensive overview of the issue.JEL classification:D31, D63, O11, Z13, C31
Role of the NLRP3/caspase-1/GSDMD signaling pathway in dopaminergic neurons during Japanese encephalitis virus infection
Authors: Guo Xiaoyan , Li Jiahuan , Lu Siyuan , Huang Zhiwei , Cheng Guofu , Hu Xueying , Zhang Wanpo , Gu Changqin 
Published: September 2023

Abstract

Background: Japanese encephalitis virus (JEV) is a highly neurotropic virus that can enter the central nervous system after high levels of peripheral replication, causing severe neuroinflammation. JEV targets dopaminergic neuron-rich areas such as the thalamus, midbrain, and striatum, causing pyroptosis. Pyroptosis, which is a novel mode of programmed cell death, plays an important role in infection by other flaviviruses, but whether it plays a role in JEV-infected neurons has not been confirmed.
Methods: In this study, the damaging effect of JEV infection on dopaminergic neurons was examined in vivo and in vitro through HE staining, immunohistochemical staining, double immunofluorescence labeling, determination of cytotoxicity, qPCR and western blotting for testing pyroptosis.
Results: Mice infected with JEV showed glial cell activation and proliferation, neuronal degeneration and necrosis, perivascular cuffing, and neuronophilia in brain tissue, and a large number of microglia were significantly activated around the virus-positive signal, as shown by immunofluorescence staining. JEV specifically targeted dopaminergic neurons, activated the nucleotide oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)/cysteinyl aspartate specific proteinase-1 (caspase-1)/gasdermin D (GSDMD) signaling pathway and induced an inflammatory response. In vitro infection of mouse midbrain dopaminergic neuron cells revealed that JEV significantly replicated in MN9D cells. Infected cells were significantly lesioned at 24 hpi, and the number of lesioned cells increased significantly with time. JEV infection resulted in a gradual increase in LDH release, indicating damage to the cytosol. JEV clearly colocalized with MN9D cells, and apoptosis occurred via an NLRP3/caspase-1/GSDMD-dependent pathway.
Conclusions: These results show that inhibiting pyroptosis can delay motor impairment caused by JEV to some extent and that protecting dopaminergic neurons from viral infection may be an effective strategy for the treatment of JEV with late effects.
Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11
Authors: Cai Rong , Li Xiaohe , Zhang Wenlong , Xing Zhengcao , Hu Shuming , Zhang Geqiang , Wang Tiange , Wang Tianshi , Fan Qiuju , Chen Guo-Qiang , Cheng Jinke , Jiang Xianguo 
Published: September 2023

Abstract
Glioblastoma (GBM) cells require large amounts of iron for tumor growth and progression, which makes these cells vulnerable to destruction via ferroptosis induction. Mitochondria are critical for iron metabolism and ferroptosis. Sirtuin-3 (SIRT3) is a deacetylase found in mitochondria that regulates mitochondrial quality and function. This study aimed to characterize SIRT3 expression and activity in GBM and investigate the potential therapeutic effects of targeting SIRT3 while also inducing ferroptosis in these cells. We first found that SIRT3 expression was higher in GBM tissues than in normal brain tissues and that SIRT3 protein expression was upregulated during RAS-selective lethal 3 (RSL3)-induced GBM cell ferroptosis. We then observed that inhibition of SIRT3 expression and activity in GBM cells sensitized GBM cells to RSL3-induced ferroptosis both in vitro and in vivo. Mechanistically, SIRT3 inhibition led to ferrous iron and ROS accumulation in the mitochondria, which triggered mitophagy. RNA-Sequencing analysis revealed that upon SIRT3 knockdown in GBM cells, the mitophagy pathway was upregulated and SLC7A11, a critical antagonist of ferroptosis via cellular import of cystine for glutathione (GSH) synthesis, was downregulated. Forced expression of SLC7A11 in GBM cells with SIRT3 knockdown restored cellular cystine uptake and consequently the cellular GSH level, thereby partially rescuing cell viability upon RSL3 treatment. Furthermore, in GBM cells, SIRT3 regulated SLC7A11 transcription through ATF4. Overall, our study results elucidated novel mechanisms underlying the ability of SIRT3 to protect GBM from ferroptosis and provided insight into a potential combinatorial approach of targeting SIRT3 and inducing ferroptosis for GBM treatment.
Multiple geophysical methods for mapping the geometry, leachate and biogas in old waste dumps in Northeast Brazil
Authors: de Vasconcelos Suzan Sousa , Batista Joelson da Conceição , Leal Luiz Rogério Bastos 
Published: September 2023

Abstract
Multiple geophysical methods are efficient for mapping the geometry of old waste dumps, detecting illegally buried waste, identifying areas enriched in leachate and biogas in landfills, and mapping contaminated sites. This paper describes the results of an electrical resistivity tomography (ERT) and magnetometric (MAG) investigation into the extensive dumping of construction and demolition waste installed in a former quarry in Northeast Brazil. Preliminary investigations using a geotechnical survey in the upper portion of the waste massif indicated the occurrence of methane gas, possible leachate at depth, concrete blocks with iron rebar, and even other metals in smaller proportions. The modeling of resistivity and magnetic data was used to delineate volumes containing metal, corresponding to low electrical resistivity values and high magnetic susceptibility. On the other hand, high resistivity measurements and low magnetic susceptibility are associated with gas or compacted and unsaturated terrain. From deep environmental drilling services and excavations in the region under study for the implementation of a subway, it was confirmed that the geophysical anomalies interpretation identified the presence of portions rich in organic matter, with high humidity, inside the dump and the presence of methane, concrete blocks, and ferrous material derived from the demolition of the construction industry.
Duplex Vermiform Appendix Left Behind after Laparoscopic Appendectomy: A Case Report
Authors: Tabatabai Seyyed Jamaluddin , Ebrahimi Abed 
Published: September 2023

Abstract
Background: Duplex appendix, a rare form of vermiform appendix, is seldom encountered. These anomalies are often found incidentally during surgery for other pathologies or occasionally due to their own involvement.
Case presentation: Here, we present a case of a 19-year-old male who initially presented to the hospital with right lower quadrant abdominal pain accompanied by nausea, vomiting, and anorexia. Physical examination revealed tenderness at the McBurney's point and rebound tenderness along with visible guarding. Blood counts showed leukocytosis. Abdominal ultrasound demonstrated an enlarged and thickened appendix. The patient underwent laparoscopic appendectomy, and then, 4 months later, he returned to the hospital with pain in the right lower quadrant, tenderness, and rebound tenderness. A diagnostic laparoscopic surgery was performed, revealing another appendix in the retrocecal area. Ultimately, the patient underwent a repeat appendectomy and was discharged from the hospital without complications after one day.
Conclusions: Acute appendicitis should not be ruled out definitively in a patient with typical clinical manifestations, especially in those with a history of laparoscopic appendectomy. Complete exploration of the cecum during surgery is the only reliable option to rule out appendix anomalies and prevent future medical complications.
Implementing Quantum Prisoner Dilemma via Different Classes of Entangled and Separable States
Authors: Makram-Allah A. T. M. , Abd-Rabbou M. Y. , Metwally N. 
Published: September 2023

Abstract
The possibility of implementing the Prisoner's Dilemma game using different classes of initial states between the players is discussed. Different behaviors of the payoffs have been exhibited, may it increases, decreases or fixed. These behaviors depend on the used initial state either maximum/partial entangled, the chosen entangling gate, and the strategies employed by each player. The increased payoff is displayed when the players adopt different defect strategies, while the fixed payoff is shown when both players apply the same defect strategy. The maximum bounds of the payoff can be attained if the players initially share a maximum entangled state. The maximum /minimum fixed payoff depends on the used entangling gate, where the maximum one is shown if the players send their final states to entangling gate. It is shown that, the nature of the payoff, whether stationary, increasing or decreasing is contingent upon the polarization of the initial state and the used defect strategy. However, if both states are polarized on the same axis direction, the predicted maximum payoff is smaller than that obtained if the initial state are polarized in different polarization of the same axis. Therefore, the initial state settings, entangling parameter and the choice of the defect strategy can be used as control tools to maximize/minimize the obtained payoff.
Late Holocene lake level changes are modulated by centennial hydroclimatic variability of southeastern South America, a case study of Laguna de las Nutrias, Uruguay
Authors: Perez Laura , Cuña-Rodríguez Carolina Celeste , Córdoba Francisco , Bueno Carolina , Crisci Carolina , Puerto Laura del , Azcune Germán , Inda Hugo , García-Rdoríguez Felipe , Piovano Eduardo 
Published: September 2023

Abstract

Laguna de las Nutrias is a small/enclosed shallow lake located within an environmentally protected area under negligible anthropogenic impact in Southeastern South America (SESA). It holds a high-resolution sedimentary record that allowed us to infer the hydrological response to the regional climatic variability during the last 700 year linked to different climate variability modes. We performed 2 mm-µXRF-scanning analyses on an 88-cm long sediment core, which was dated by both 14C and 210Pb techniques. We utilized Ti/Al, Ti/Ca, Fe/Mn, Ti/K, S/Ti, Br/Ti, and Si/Ti as proxies for catchment runoff, lake level, redox conditions, grain size, organic matter, storms/extreme events, and trophic state, respectively. The lowest sedimentation rate, lake level, runoff values, highest trophic state and grain size were recorded between 1360–1800 CE, assigned to the Little Ice Age (LIA), under low humidity conditions related to the weakening of the South American Low-Level Jet (SALLJ). Subsequently, the highest sedimentation rate values, runoff and lake level were recorded up to the present. Concomitant lowest trophic state conditions were inferred and interpreted as dilution processes associated with higher lake levels. This stage was assigned to the onset of the Current Warm Period (CWP), which was characterized by higher humidity conditions leading to the highest sedimentation rate, lake level and runoff values after 1980 CE, associated with the noticeable increase in rainfall during “1970´s climatic shift”. By performing time series analyses, we determined centennial, multi-decadal, decadal, and inter-annual cyclicity in lake level related to the hydroclimatic variability. Furthermore, a high significant positive/negative Spearman correlation was observed between runoff and lake level/trophic state proxies and the El Niño Southern Oscillation (ENSO) reconstruction. ENSO modulates both long and short-term frequency of SALLJ, leading to an increase in rainfall during positive phases, which determined high lake level and runoff and a decreased trophic state due to dilution processes. The reconstructed hydrological variability herein is synchronic with other SESA lacustrine systems and the increased Rio de la Plata discharge, indicating similar long-term limnological responses to the regional climatic patterns.
Defining quality indicators, pharmaceutical care bundles and outcomes of clinical pharmacy service delivery using a Delphi consensus approach
Authors: Canning Martin , Barras Michael , McDougall Ross , Yerkovich Stephanie , Coombes Ian , Sullivan Clair , Whitfield Karen 
Published: September 2023

Abstract

Background Clinical pharmacists perform patient-centred activities to optimise medicines use and prevent harm. Clinical pharmacy quality indicators (CPQI) are often non-uniform and measure individual activities and are not linked to outcomes. Aim To define a consensus agreed pharmaceutical care bundle (PCB) and patient outcome measures across an entire State jurisdiction. Methods A four-round modified-Delphi approach with State Directors of Pharmacy (DOPS) was performed (n = 25). DOPS were asked to rate on a 5-point LIKERT scale the relevance and measurability of 32 inpatient CPQI as well as outcome measures. They also ranked clinical pharmacy activities in order from perceived most to least beneficial. Based upon this ranking, groups of indicators were proposed as PCB, and relevance and measurability assessed. Results Response rate ranged from 40–60% between rounds. Twenty-six individual CPQI reached consensus. The top ranked CPQI was the proportion of patients where a pharmacist documents an accurate list of medicines during admission. There were nine PCB formed consisting between 3 and 7 activities. Only one PCB reached consensus: medication history, adverse drug reaction/allergy documentation, admission and discharge medication reconciliation, medication review, provision of medicines education and provision of a medication list on discharge. Sixteen outcome measures reached consensus. The top ranked were hospital acquired complications, readmission due to medication misadventure and unplanned readmission within 10 days. Conclusion Consensus has been reached on one PCB and sixteen outcomes to monitor clinical pharmacy service delivery. The next step is to measure the extent of PCB delivery and the link to patient outcomes.
Comparison of long-term outcomes between implantable collamer lens V4c and FS-LASIK for myopia correction with presbyopia
Authors: Ye Yuhao , Liu Fang , Zhang Zhe , Niu Lingling , Shi Wanru , Wang Xiaoying , Zhao Jing , Zhou Xingtao 
Published: September 2023

Abstract
Purpose: To compare the long-term safety and efficacy of monovision surgery using implantable collamer lens (ICL) V4c and femtosecond laser-assisted in situ keratomileusis (FS-LASIK) in myopic patients with early presbyopia.
Setting: Eye and ENT Hospital of Fudan University,shanghai, China.
Design: Case series study.
Methods: 48 eyes of 24 patients were included (male/female: 10/14, mean age 45.50±3.82 years). We recorded parameters including mean spherical equivalent, uncorrected distance visual acuity, corrected distance visual acuity, intraocular pressure, presbyopic add power, visual acuity (VA) (logMAR) of dominant eyes (D-eye), non-dominant (nD-eye) eyes, and both eyes (Bi) at 0.4 m, 0.8 m, and 5 m, corneal wavefront aberration, and contrast sensitivity (CS) at the last follow-up (4.5 years, 54.00±9.77 months). Statistical significance was set at p<0.05.
Results: All surgeries were uneventful. The safety indices of ICL V4c group and FS-LASIK group were 1.17±0.30 and 0.98±0.20 (p<0.05), and the efficacy indices were 0.79±0.07 and 0.52±0.07 (p<0.05) respectively. The binocular VA (logMAR) of ICL V4c group and FS-LASIK group at 5.0 m were: 0.02±0.11, 0.18±0.30; 0.8 m: 0.09±0.12, -0.01±0.11; 0.4 m: -0.02±0.06, -0.03±0.08, (p>0.05 at three distances). Compared with ICL V4c group, lower CS was observed at 1.0 cpd in the FS-LASIK group (1.07±0.31 vs. 0.80±0.51, p=0.043).
Conclusions: Implantable collamer lens V4c and FS-LASIK are safe and practicable for correction of myopes with presbyopia. Compared with the FS-LASIK group, the ICL V4c group showed superior CS in nD-eyes in low spatial frequency.
Ni3S2/ZrCoFe-LDH@NF heterojunction catalysts for efficient Overall water Splitting
Authors: Guo Yuchen , Zou Xiangyu , Wei Xueling , Bao Weiwei , Han Jie , Jia FeiHong 
Published: September 2023

Abstract
With the continuous depletion of traditional energy sources, the development of sustainable energy sources has become one of the important tasks today. A two-step synthesis method was employed to construct Ni3S2/ZrCoFe-LDH@NF heterostructured electrocatalysts on nickel grid (NF) in situ. X-ray diffractometer, scanning electron microscope, transmission electron microscope and X-ray electron spectroscopy were employed to characterize the Ni3S2/ZrCoFe-LDH@NF heterostructure, and the HER, OER and total hydrolysis properties of this electrocatalyst were tested in 1 mol·L− 1 KOH electrolyte. It was shown that Ni3S2/ZrCoFe-LDH@NF was a lamellar stacked heterostructure with an overpotential of 330 mV and a Tafel slope of 90.9 mV·dec− 1 at a current density of 100 mA·cm− 2 in the OER reaction and 159.2 mV at a current density of 10 mA·cm− 2 in the OER reaction. Tafel slope was 96 mV·dec− 1, and the catalyst exhibited good structural stability in the 100 h total hydrolysis stability test. The successful construction of this heterostructured electrocatalyst provides a good idea and research basis for the subsequent heterojunction and its application in electrocatalysis.