bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of volatile anesthetics for sedation in the ICU during the COVID-19 pandemic: A national survey in France (VOL’ICU 2 study)
Authors: Blondonnet Raiko , Balde Aissatou , Zhai Ruoyang , Pereira Bruno , Futier Emmanuel , Bazin Jean-Etienne , Godet Thomas , Constantin Jean-Michel , Lambert Céline , Jabaudon Matthieu 
Published: December 2022

Background
The COVID-19 pandemic has increased the number of patients in ICUs leading to a worldwide shortage of the intravenous sedative agents obligating physicians to find alternatives including inhaled sedation. Inhaled sedation in French ICU has been previously explored in 2019 (VOL’ICU study). This survey was designed to explore the use of inhaled sedation two years after our first survey and to evaluate how the COVID-19 pandemic has impacted the use of inhaled sedation.

Methods
We designed a national survey, contacting medical directors of French ICUs between June and October 2021. Over a 50-item questionnaire, the survey covered the characteristics of the ICU, data on inhaled sedation, and practical aspects of inhaled ICU sedation for both COVID-19 and non-COVID-19 patients. Answers were compared with the previous survey, VOL’ICU.

Results
Among the 405 ICUs contacted, 25% of the questionnaires were recorded. Most ICU directors (87%) knew about the use of inhaled ICU sedation and 63% of them have an inhaled sedation’s device in their unit. The COVID-19 pandemic increased the use of inhaled sedation in French ICUs. The main reasons said by the respondent were “need for additional sedative” (62%), “shortage of intravenous sedatives” (38%) and “involved in a clinical trial” (30%). The main reasons for not using inhaled ICU sedation were “device not available” (76%), “lack of familiarity” (60%) and “no training for the teams” (58%). More than 70% of respondents were overall satisfied with the use of inhaled sedation. Almost 80% of respondents stated that inhaled sedation was a seducing alternative to intravenous sedation for management of COVID-19 patients.

Conclusion
The use of inhaled sedation in ICU has increased fastly in the last 2 years, and is frequently associated with a good satisfaction among the users. Even if the COVID-19 pandemic could have impacted the widespread use of inhaled sedation, it represents an alternative to intravenous sedation for more and more physicians.
Extension of the Composite Quality Score (CQS) as an appraisal tool for prospective, controlled clinical therapy trials–A systematic review of meta-epidemiological evidence
Authors: Mickenautsch Steffen , Rupf Stefan , Miletić Ivana , Yengopal Veerasamy 
Published: December 2022

Aim
To conduct a survey of current meta-epidemiological studies to identify additional trial design characteristics that may be associated with significant over- or underestimation of the treatment effect and to use such identified characteristics as a basis for the formulation of new CQS appraisal criteria.

Materials and methods
We retrieved eligible studies from two systematic reviews on this topic (latest search May 2015) and searched the databases PubMed and Embase for further studies from June 2015 –March 2022. All data were extracted by one author and verified by another. Sufficiently homogeneous estimates from single studies were pooled using random-effects meta-analysis. Trial design characteristics associated with statistically significant estimates from single datasets (which could not be pooled) and meta-analyses were used as a basis to formulate new or amend existing CQS criteria.

Results
A total of 38 meta-epidemiological studies were identified. From these, seven trial design characteristics associated with statistically significant over- or underestimation of the true therapeutic effect were found.

Conclusion
One new criterion concerning double-blinding was added to the CQS, and the original criteria for concealing the random allocation sequence and for minimum sample size were amended.
Erector spinae plane block versus thoracic paravertebral block for the prevention of acute postsurgical pain in breast cancer surgery: A prospective observational study compared with a propensity score-matched historical cohort
Authors: Premachandra Antoine , Wang Xiaomeng , Saad Mary , Moussawy Sahar , Rouzier Roman , Latouche Aurélien , Albi-Feldzer Aline 
Published: December 2022

Background
Preventing acute postsurgical pain (PSP) following breast cancer surgery is a major issue. Thoracic paravertebral block (TPVB) has been widely studied for this indication. Erector spinae plane block (ESPB) has been assumed to be effective. We aimed to compare the efficacy and safety of ESPB over TPVB in preventing acute PSP.

Methods
In this prospective observational study, 120 patients admitted for unilateral major oncologic breast surgery received T2/T3 ESPB (ropivacaine 0.75%, 0.35 ml.kg-1), and 102 were analysed. Then, the ESPB cohort was compared to a TPVB cohort from the experimental arm of a randomized controlled study with the same protocol (NCT02408393) using propensity score matching analysis. The primary outcome was the need for morphine consumption in the PACU. Secondary outcomes were the morphine total dose, the incidence of ESPB and TPVB complications, and discontinuous visual analogue scale measurement trends at rest and at mobilization in the 24 hours after surgery.

Results
A total of 102 patients completed the study between December 2018 and August 2019. Propensity score matching formed 94 matched pairs. The proportion of morphine titration in the PACU was higher in the ESPB group than in the TPVB group (74.5% vs. 41.5%, p<0.001), with a between-group difference of 33.0% (95% CI [19.3%, 46.7%]). No ESPB-related complications were observed.

Conclusion
ESPB is less effective in preventing morphine consumption in the PACU than TPVB. Our findings do not support the use of ESPB as the first-line regional anaesthesia for major breast cancer surgery. Randomized trials comparing ESPB and TPVB are needed.
Preventive ceftriaxone in patients at high risk of stroke-associated pneumonia. A post-hoc analysis of the PASS trial
Authors: Sluis Wouter M. , Westendorp Willeke F. , van de Beek Diederik , Nederkoorn Paul J. , van der Worp H. Bart 
Published: December 2022

Background
Infections complicate the acute phase of stroke in one third of patients and especially pneumonia is associated with increased risk of death or dependency. In randomized trials of stroke patients, preventive antibiotics reduced overall infections, but did not reduce pneumonia or improve outcome. This may be explained by broad selection criteria, including many patients with a low risk of pneumonia. To assess the potential of selection of patients at high risk of pneumonia, we performed a post-hoc analysis in the Preventive Antibiotics in Stroke Study (PASS).

Methods
PASS was a multicentre phase 3 trial in acute stroke patients who were randomized to preventive ceftriaxone for four days within 24 hours or standard care. For this analysis patients were divided based on the ISAN risk score for pneumonia as follows: low (0–6), medium (7–14) and high (15–21). Primary outcomes were pneumonia rate during admission as judged by the treating physician, and by an independent committee; secondary outcomes were overall infections and unfavorable outcome (modified Rankin Scale ≥3). We adjusted with multivariable regression for possible confounders: age, stroke subtype and severity, pre-stroke dependency and diabetes.

Results
Pneumonia occurred more frequently in higher risk groups (25.7% (high), 9.0% (medium) 1.5%, (low)). The absolute difference in pneumonia rate between patients treated with ceftriaxone or standard care increased with the ISAN score (low: 0.5%, medium: 1.2%, high: 10.1%). After adjustment ceftriaxone reduced overall infections in the low and medium groups, not in the high-risk group. There was a trend towards reduction of pneumonia as judged by the committee (3.7% vs 13.6%, aOR = 0.164, p = 0.063) in the high-risk group.

Conclusions
This post-hoc analysis of PASS confirmed higher rates of pneumonia with higher ISAN scores, and suggests that in acute stroke patients with an ISAN score of ≥15, preventive ceftriaxone for four days may reduce pneumonia rate.
Tactile sensitivity and motor coordination in infancy: Effect of age, prior surgery, anaesthesia & critical illness
Authors: Cornelissen Laura , Underwood Ellen , Gabard-Durnam Laurel J. , Soto Melissa , Tao Alice , Lobo Kimberly , Hensch Takao K. , Berde Charles B. 
Published: December 2022

Background
Tactile sensitivity in the infant period is poorly characterized, particularly among children with prior surgery, anaesthesia or critical illness. The study aims were to investigate tactile sensitivity of the foot and the associated coordination of lower limb motor movement in typically developing infants with and without prior hospital experience, and to develop feasible bedside sensory testing protocols.

Materials and methods
A prospective, longitudinal study in 69 infants at 2 and 4 months-old, with and without prior hospital admission. Mechanical stimuli were applied to the foot at graded innocuous and noxious intensities. Primary outcome measures were tactile and nociceptive threshold (lowest force required to evoke any leg movement, or brisk leg withdrawal, respectively), and specific motor flexion threshold (ankle-, knee-, hip-flexion). Secondary analysis investigated (i) single vs multiple trials reliability, and (ii) the effect of age and prior surgery, anaesthesia, or critical illness on mechanical threshold.

Results
Magnitude of evoked motor activity increased with stimulus intensity. Single trials had excellent reliability for knee and hip flexion at age 1-3m and 4-7m (ICC range: 0.8 to 0.98, p >0.05). Nociceptive threshold varied as a function of age. Tactile sensitivity was independent of age, number of surgeries, general anaesthesia and ICU stay.

Conclusions
This brief sensory testing protocol may reliably measure tactile and nociceptive reactivity in human infants. Age predicts nociceptive threshold which likely reflects ongoing maturation of spinal and supraspinal circuits. Prior hospital experience has a negligible global effect on sensory processing demonstrating the resilience of the CNS in adverse environments.
DEVELOPMENT AND VALIDATION OF METHOD FOR ISOLATION AND QUANTITATIVE DETERMINATION OF WATER-SOLUBLE POLYSACCHARIDES FROM SUNFLOWER ROOTS OF ONE-YEAR-OLD
Authors: Dyakova Nina Alekseyevna 
Published: December 2022

The aim of the study was to develop and validate an express method for the isolation and quantitative determination of water-soluble polysaccharides from the roots of sunflower of a one-year-old. To accelerate the process of extracting biologically active substances from the roots of one-year-old sunflower, as well as increasing the yield of water-soluble polysaccharides, it was decided to use an ultrasonic bath. Varying the process parameters, it was possible to select the optimal conditions for extracting water-soluble polysaccharides of sunflower roots of one-year-old under ultrasound treatment conditions: crushing of raw materials 0.5–1.0 mm, temperature – 80 °C, extraction rate – 3, duration of extractions - 30 minutes, ultrasound frequency – 30 kHz, ratio of raw materials and extractant 1 g per 15 ml. The proposed technique allows intensifying the process of producing water-soluble polysaccharides from sunflower roots of one-year old and reducing the time spent on it to 5–6 hours, as well as increasing the product yield to 16.29% in terms of absolutely dry raw materials. The developed technique is precision in the conditions of repeatability, correct, stable and has a fairly rigid linear dependence of the mass of the sediment on the mass of the analyzed raw materials in gravimetric determination of water-soluble polysaccharides in the roots of sunflower of a one-year-old. The procedure can be used for express analysis of the quality of sunflower roots of one-year old, as well as in industrial production of water-soluble polysaccharides from this kind of raw material.
STUDY OF THE PROCESS OF CARBONIZATION OF POWDERED CELLULOSE GRANULES IMPREGNATED WITH AgNO3 AND Pd(NO3)2
Authors: Shishmakov Andrey Borisovich , Mikushina Yuliya Vladimirovna , Koryakova Ol'ga Vasil'yevna 
Published: December 2022

A comparative study of the process of carbonization of powdered cellulose granules and powdered cellulose granules impregnated with silver and palladium nitrate salts was carried out. The process was carried out in the temperature range 200–600 °С. The influence of the presence of metals on the course of carbonization of powdered cellulose and the features of the reduction of silver and palladium during carbonization were studied by IR spectroscopy and X-ray phase analysis. It has been established that the presence of silver in powdered cellulose does not affect the yield of carbonized material. The presence of palladium in powdered cellulose leads to the fact that the yield of carbonizate in the temperature range of 300–600 °C is reduced relative to the yield of carbonizate simply from powdered cellulose. It has been established by IR spectroscopy that impregnation with salts and subsequent drying at 90 °C of powdered cellulose granules leads to the appearance of carboxyl groups in it, which are not observed in unimpregnated powdered cellulose. With an increase in the heat treatment temperature to 200 °C, the amount of these groups in the silver-containing material increases sharply, while in the palladium-containing material it remains unchanged. A significant increase in the number of C=O groups in the palladium-containing material begins at 300 °C. The increased relative content of C=O groups in the metal-containing material is also preserved in the temperature range of 300–500 °C. The presence of metals in powdered cellulose at pyrolysis temperatures of 300–500 °C leads to a decrease in the content of C=C groups in the carbon matrix relative to methylene (methine) groups. At 600 °C, the carbon matrix of all coals is completely carbonized. X-ray diffraction analysis recorded the appearance of metallic silver and palladium in metal-containing coals at a temperature of 300 °C As the carbonization temperature increases, the content of crystalline Ag(0) and Pd(0) in coals increases. No other forms of silver and palladium are found in the temperature range of 300–600 °С. Testing of metal-containing coals in a model reaction of hydrogen peroxide decomposition showed: in silver-containing carbonizates, the availability of silver particles for H2O2 increases due to an increase in the pyrolysis temperature; in Pd/C, an additional factor that increases the availability of metal particles is the interaction of palladium with carbonizate during pyrolysis.
SPECIES OF THE GENUS AGASTACHE J.CLAYTON EX GRONOV.: DISTRIBUTION, USE, DEGREE OF KNOWLEDGE (REVIEW)
Authors: Kolomiets Natalia Eduardovna , Shplis Olga Nikolaevna 
Published: December 2022

The review summarizes information from the literature on the distribution, systematics, study of the composition and biological activity of metabolites, total extracts of plants of the genus Agastache J.Clayton ex Gronov. To date, 22 species of the genus are known, most of them are endemic to North America. Only one species – Agastache rugosa is grows in Asia and Russian Far East. Only 7 species of this genus are known to be used in ethnomedicine. In the world's official medicine, species of the genus are not used, with the exception of A. rugosa, which is a means of traditional Chinese medicine and is part of several well-known, often prescribed herbal remedies. The most studied composition of metabolites and pharmacological properties of .Agastache rugosa, A. foeniculum, A.mexicana. There is no information in the literature about A.eplingiana, A. breviflora, A. cusickii, A.mearnsii, A. pallida, A. pallidiflora, A. palmeri. Over 90 substances related to terpenoids, fatty acids, phenolcarboxylic acids, tannins, vitamins, lignans, sterols, amino acids, flavonoids, macro- and microelements and etc. Total extracts and individual compounds of the studied species in the experiment have a wide range of pharmacological activity: anxiolytic, antidepressant, antihypertensive, antinociceptive, antibacterial, insecticidal, immunotropic, antiviral, antimutagenic, cytotoxic. The information provided in the review shows that plants of the genus Agastache, are promising for further study and use in various industries.
Fragmentation and lack of information on the composition of metabolites, pharmacological activity of most species of the genus Agastache opens up great opportunities for researchers from different areas of scientific knowledge.
THE STUDY OF ANTIMICROBIAL AND ANALGESIC ACTIVITY OF CERTAIN CYTIZINE ALKALOID COMBINED DERIVATIVES
Authors: Mukusheva Gulim Kenesbekovna , Seidakhmetova Roza Battalovna , Zhassymbekova Aigerim Rysbekovna , Nurkenov Oralgazy Aktaevich , Nurmaganbetov Zhangeldy Seitovich , Seilkhanov Tulegen Muratovich , Tazhybay Aizhan Maratovna , Mazhytov Alisher Sabyrovich 
Published: December 2022

The modern vegetable matter studies in the republic and abroad are devoted to a multi-faceted and comprehensive research of plant raw materials, including desorbing and structure of plant component chemical properties, the study of their biological activity, as well as the development of effective and environmentally friendly methods for соmprehensive mineral processing of plant raw materials.
The 1,2,3-triazoles attraction is due to their reactivity versatility, as well as practical application of 1,2,3-triazole derivatives as medicines. Modification of natural compound molecules by introducing such a substituent is one of promising directions in the search for new biologically active compounds.
According to the data obtained, the antimicrobial activity of sample (5) is higher than that of sample (3). Thus, sample (5) showed a moderate antibacterial activity against Escherichia coli, whereas sample (3) showed a weak antimicrobial activity against this test strain.
The analysis of test results concerning the analgesic activity assessment showed that samples (5) and (3) can reduce the rats ‘specific nociceptive responses severity when testing abdominal constriction. It is important to emphasize that when injecting a 1% acetic acid solution abdominally, all test animals developed “acetic writhing’s” (characteristic animal movements, including the abdominal muscles contraction, alternating with their relaxation, hind limbs stretching and back arching).
CHEMICAL CONSTITUENTS AND ANTIBACTERIAL PROPERTIES OF KITAGAWIA BAICALENSIS (REDOW. EX WILLD.) PIMENOV ESSENTIAL OILS
Authors: Tykheev Zhargal Aleksandrovich , Dylenova Elena Petrovna , Taraskin Vasiliy Vladimirovich , Taraskina Anna Sergeyevna , Zhigzhitzhapova Svetlana Vasil'yevna 
Published: December 2022

Kitagawia baicalensis (Redow. ex Willd.) Pimenov (Umbelliferae) is a perennial monocarpic plant with Siberian-Mongolian type of habitats. Decoction of flowers and roots has been used in Tibetan medicine for intoxication and as diuretic agent to treat edema. The essential oils of the aerial part of K. baicalensis growing within the territory of the Republic of Buryatia were obtained by steam distillation method. The isolated essential oils were yellow oily liquids, lighter than water, with characteristic pleasant odour. The qualitative composition and quantitative content of the components of essential oils were determined by GC/MS. 26 compounds with aromatic, mono- and sesquiterpenoid structures were identified in the composition of essential oils. The main components of the essential oils of the aerial part of the Kitagawia baicalensis from Buryatia were limonene (34.40%), β-myrcene (21.10%), γ-terpinene (12.60%), β-elemen (5.70%), sabinene (5.30%), germacren B (3.20%) and germacrene D (3.10%). Monoterpenoids (83.00%) predominated in general composition of essential oils. The content of compounds with sesquiterpenoid structure was 14.70%. The group of aromatic compounds was represented only by p-cymene (2.30%). Bactericidal and bacteriostatic activities of essential oils against Bacillus cereus, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, Aspergillus niger, Candida albicans were determined in this paper. The most pronounced antibacterial effect of essential oils was found against Streptococcus pyogenes (1 : 64 dilution).
INTERRELATION OF INDIVIDUAL PAPER-FORMING PROPERTIES AND THE DYNAMIC VISCOSITY COEFFICIENT DURING THE GRINDING OF THE FIBROUS MASS
Authors: Alashkevich Yuriy Davydovich , Fomkina Anna Aleksandrovna , Karelina Aleksandra Aleksandrovna 
Published: December 2022

The refining process is associated with the movement of large masses of fibrous suspensions in the working bodies of refining machines, which affects both the refining process itself and energy consumption when moving the fibrous suspension. In this regard, the efficiency of refining equipment can be ensured on the basis of knowledge of the hydrodynamic processes that occur during the interaction of the working bodies of refining equipment with a fibrous suspension.
During the flow of fibrous suspensions, the basic rheological feature is their viscosity, which makes it possible to judge the internal forces acting in the flow. This is especially important for the bladeless refining method using the “jet-barrier” installation.
In order to most fully judge the direction of the refining process (in the direction of the transverse shortening of the fibers or in the direction of their longitudinal fibrillation), it is necessary to control the paper-forming properties of the fibrous mass and the physical and mechanical properties of the castings.
The publication presents an analysis of the influence of the paper-forming properties of the fibrous mass on the quality of its refining, it is advisable to find the dependence of these indicators on the rheological features of the fibrous suspension flow in the refining zone, that is, to determine the relationship of the paper-forming properties of the fibrous mass with the dynamic viscosity coefficient during the flow of the fibrous suspension in the refining zone.
HYDROGENATION OF ABIES WOOD ETHANOL-LIGNIN WITH HYDROGEN IN ETHANOL MEDIUM IN THE PRESENCE OF NiCuMo/SiO2 CATALYST
Authors: Kuznetsov Boris Nikolayevich , Miroshnikova Angelina Viktorovna , Kazachenko Aleksandr Sergeyevich , Baryshnikov Sergey Viktorovich , Malyar Yuriy Nikolayevich , Skripnikov Andrey Mikhaylovich , Fetisova Ol'ga Yur'yevna , Yakovlev Vadim Anatol'yevich , Taran Oksana Pavlovna 
Published: December 2022

In the development of studies on the catalytic conversion of lignin to liquid hydrocarbons, the effect of the bifunctional NiCuMo/SiO2 catalyst on the yield and composition of abies wood ethanol-lignin hydrogenation products in ethanol medium at a temperature of 250 °C was established. According to thermogravimetric analysis data the main thermal decomposition of abies wood ethanol-lignin occurs in the range from 260 to 600 °C with the maximum rate of degradation (3.9%/min) at 398.3 °C. The catalyst increases the yield of liquid products from 75.0 to 88.0 wt%, and reduces the yield of solid residue from 14.0 to 0.6 wt%. The total yield of phenolic compounds of non-catalytic hydrogenation does not exceed 4.5 wt%. The bifunctional nickel-containing catalyst increases by two times (up to 9.2 wt.%) the yield of liquid phenolic products, among which dimers and 4-propyl guaiacol predominate. The molecular weight distribution of the liquid products of the catalytic hydrogenation of abies ethanol-lignin shifts to the low molecular weight region due to the increase in the content of dimeric and monomeric phenolic compounds in liquid products. The obtained methoxyphenols can be used as components of epoxy resins, polycarbonates, fuel additives, and in other areas.