bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemoproteomic and Transcriptomic Analysis Reveals that O‐GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network
Authors: Hao Yi , Li Xiang , Qin Ke , Shi Yujie , He Yanwen , Zhang Che , Cheng Bo , Zhang Xiwen , Hu Guangyu , Liang Shuyu , Tang Qi , Chen Xing 
Published: March 2023

AbstractSelf‐renewal and differentiation of embryonic stem cells (ESCs) are influenced by protein O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) modification, but the underlying mechanism remains incompletely understood. Herein, we report the identification of 979 O‐GlcNAcylated proteins and 1340 modification sites in mouse ESCs (mESCs) by using a chemoproteomics method. In addition to OCT4 and SOX2, the third core pluripotency transcription factor (PTF) NANOG was found to be modified and functionally regulated by O‐GlcNAc. Upon differentiation along the neuronal lineage, the O‐GlcNAc stoichiometry at 123 sites of 83 proteins—several of which were PTFs—was found to decline. Transcriptomic profiling reveals 2456 differentially expressed genes responsive to OGT inhibition during differentiation, of which 901 are target genes of core PTFs. By acting on the core PTF network, suppression of O‐GlcNAcylation upregulates neuron‐related genes, thus contributing to mESC fate determination.
Ligand‐Enabled Palladium(II)‐Catalyzed Enantioselective β‐C(sp3)−H Arylation of Aliphatic Tertiary Amides**
Authors: Yuan Chen‐Hui , Wang Xiao‐Xia , Jiao Lei 
Published: March 2023

AbstractAmide is one of the most widespread functional groups in organic and bioorganic chemistry, and it would be valuable to achieve stereoselective C(sp3)−H functionalization in amide molecules. Palladium(II) catalysis has been prevalently used in the C−H activation chemistry in the past decades, however, due to the weakly‐coordinating feature of simple amides, it is challenging to achieve their direct C(sp3)−H functionalization with enantiocontrol by PdII catalysis. Our group has developed sulfoxide‐2‐hydroxypridine (SOHP) ligands, which exhibited remarkable activity in Pd‐catalyzed C(sp2)−H activation. In this work, we demonstrate that chiral SOHP ligands served as an ideal solution to enantioselective C(sp3)−H activation in simple amides. Herein, we report an efficient asymmetric PdII/SOHP‐catalyzed β‐C(sp3)−H arylation of aliphatic tertiary amides, in which the SOHP ligand plays a key role in the stereoselective C−H deprotonation‐metalation step.
pH‐Triggered Molecular Switch Toward Texture‐Regulated Zn Anode
Authors: Zhang Shao‐Jian , Hao Junnan , Zhu Yilong , Li Huan , Lin Zhan , Qiao Shi‐Zhang 
Published: March 2023

AbstractZn electrodes in aqueous media exhibit an unstable Zn/electrolyte interface due to severe parasitic reactions and dendrite formation. Here, a dynamic Zn interface modulation based on the molecular switch strategy is reported by hiring γ‐butyrolactone (GBL) in ZnCl2/H2O electrolyte. During Zn plating, the increased interfacial alkalinity triggers molecular switch from GBL to γ‐hydroxybutyrate (GHB). GHB strongly anchors on Zn surface via triple Zn−O bonding, leading to suppressive hydrogen evolution and texture‐regulated Zn morphology. Upon Zn stripping, the fluctuant pH turns the molecular switch reaction off through the cyclization of GHB to GBL. This dynamic molecular switch strategy enables high Zn reversibility with Coulombic efficiency of 99.8 % and Zn||iodine batteries with high‐cyclability under high Zn depth of discharge (50 %). This study demonstrates the importance of dynamic modulation for Zn electrode and realizes the reversible molecular switch strategy to enhance its reversibility.
Einblicke in die Rolle von Graphitkohlenstoffnitrid als Photobase beim protonengekoppelten Elektronentransfer bei der (sp3)C−H‐Oxygenierung von Oxazolidinonen
Authors: Galushchinskiy Alexey , Zou Yajun , Odutola Jokotadeola , Nikačević Pavle , Shi Jian‐Wen , Tkachenko Nikolai , López Núria , Farràs Pau , Savateev Oleksandr 
Published: March 2023

AbstractGraphitisches Kohlenstoffnitrid (g‐CN) ist ein übergangsmetallfreier Halbleiter, der eine Vielzahl von photokatalytischen Reaktionen unterstützt. Obwohl oft ein photoinduzierter Elektronentransfer als Mechanismus postuliert wird, ist der protonengekoppelte Elektronentransfer (PCET) der bevorzugte Weg für Substrate mit X−H‐Bindungen. Bei der Anregung einer (sp2)N‐reichen Struktur von g‐CN mit sichtbarem Licht verhält sie sich wie eine Photobase – es kommt zu einem reduktivem Quenching, begleitet von der Abstraktion eines Protons aus einem Substrat. Die Ergebnisse der Modellierung ermöglichten es uns, aktive Stellen für PCET zu identifizieren – die “dreieckigen Taschen” an den Kantenfacetten von g‐CN. Excited‐State‐PCET vom Substrat zu g‐CN wurde eingesetzt um dieendo‐(sp3)C−H‐Bindung in Oxazolidin‐2‐onen selektiv zu spalten, gefolgt vom Einfangen des Radikals mit O2. Diese Reaktion ergibt 1,3‐Oxazolidin‐2,4‐Dionen. Die Messung des scheinbaren pKa‐Wertes und die Modellierung deuten darauf hin, dass der angeregte g‐CN‐Zustand X−H‐Bindungen spalten kann, die durch eine freie Bindungsdissoziationsenergie (BDFE) von ≈100 kcal mol−1gekennzeichnet sind.
Synergistic flame retardant effect of cerium‐based DOPO derivative and intumescent flame retardants in polypropylene
Authors: Zhang Yan , Lin Fenglong , Wu Yincai , Wang Shenglong , Liu Ziteng , Song Lijun 
Published: March 2023

AbstractIn this study, cerium based DOPO derivative (Ce@DDP) was synthesized by hydrothermal method, and its effects on flame retardancy, thermal stability, and mechanical properties of intumescent flame retardant polypropylene (PP) are investigated. When addition of 17 wt% of intumescent flame retardants (IFR) and 1 wt% of Ce@DDP, the results indicate that the peak heat release rate (PHRR) and peak smoke production rate (PSPR) of the resulted PP composite is reduced by 62.0% and 42.3%, respectively. Meanwhile, the vertical burning rating reaches UL94 V‐0, and the limiting oxygen index (LOI) is 33.8%. Furtherly, the Ce@DDP significantly improves the thermal stability and char formation ability of PP/IFR. Notably, Ce@DDP exhibits better synergistic flame retardant and mechanical strength for PP/IFR than CeO2. Finally, it was speculated that there was dilution effect and radical quenching effect in gas phase, and catalytic carbonization effect in condensed phase of IFR/Ce@DDP system, and the combined action of the these aspects led to high‐efficiency flame retardant.
High vinyl polybutadiene rubber/polypropylene thermoplastic elastomer blends: Optimization of internal mixing process parameters and screening of processing methods
Authors: Yue Song , Liu Yudong , Geng Jieting , Hua Jing 
Published: March 2023

AbstractThermoplastic vulcanizates (TPV) composed of high vinyl polybutadiene rubber (HVPB) and polypropylene (PP) have good thermal stability and damping properties. This work aims to apply a design of experiments (Taguchi L9 orthogonal array) to optimize the mixing parameters (rotor speed, temperature, and time) for the HVPB/PP TPV. The effects of these mixing parameters on its physical and mechanical properties of HVPB/PP TPV follow the order: rotor speed > temperature and time. In the case of the master batch process, the optimum mixing parameters are 60 rpm, 180°C and 8 min. Subsequently, four processes (master batch, static vulcanization, rubber‐plastic premixing, and two‐step processing) are compared using the same optimum mixing parameters. The master batch process turns out to be the best in terms of physical and mechanical properties.
Reconstructing the ancient route network in the Thailand–Cambodia borders: A case study of the Angkorian Royal Road
Authors: Khamsiri Sutthikan , Venunan Pira , Khaokheiw Chawalit , Silapanth Praon , Pailoplee Santi 
Published: March 2023

AbstractA large number of ancient remnants from the Angkor kingdom of the 15th–19th centuries are widely observable across present day north‐eastern Thailand and Cambodia. Archaeologically, these features represent the ancient communities and were possibly connected according to various socioeconomic reasons. In order to reconstruct the route of human mobility between the remains, the geographic information system (GIS)‐based least cost path (LCP) analysis was employed along the Angkor–Phimai route. By recognizing the geographic parameters, the mobility of 292 moated sites was tracked to eight mountain passes that traverse the barrier of the Dângrêk Mountain Range. The LCP‐derived routes revealed that the Ta Muen pass was the most suitable (shortest source‐to‐site distance) route for almost all moated sites. When compared with a previous interpretation of the Angkorian Royal Road route, our LCP route conforms reasonably well when overlaid with this possible Royal Road. The locations of ancient activities were also in the vicinity of the dense LCP route, and most monuments were located within a 1.5 km buffer line. This underlines that the LCP track obtained in this study is reasonable with a high reliability and is beneficial for guiding further studies to find out more about the ancient remains or archaeological evidence in this area.
Mechanistic Insights into Enantioselective C(sp3)−H Acylation to Construct α‐Amino Ketones via Photoredox and Ni(II) Dual Catalysis: A DFT Study
Authors: Liu Ran , Lv Kang , Bao Xiaoguang 
Published: March 2023

AbstractThe development of the merger of a Ni(II) catalyst with an appropriate photocatalyst under visible‐light irradiation provides a new strategy for realizing direct functionalization of C(sp3)−H bonds. Mechanistically, whether the reduction of Ni catalyst to form a Ni(0) species is necessary in the dual catalysis still remains under debate. Herein, DFT calculations were carried out to gain a mechanistic insight into the enantioselective acylation of α‐amino C(sp3)−H bonds to furnish α‐amino ketones via photoredox and Ni dual catalysis. A feasible mechanistic pathway for the Ni catalysis via the Ni(I)−Ni(III)−Ni(II)−Ni(III)−Ni(I) cycle is suggested with the sequential elementary steps of oxidative addition, single electron reduction, radical addition, and reductive elimination in leading to the final product, whereas a nickel catalytic cycle, Ni(I)−Ni(0)−Ni(II)−Ni(III)−Ni(I), might not be feasible for the photoredox and Ni dual‐catalyzed acylation of α‐amino C(sp3)−H bonds. The origin of the stereoselectivity for this reaction is also discussed, which could be attributed to the minimization of the steric hindrance between the alkyl moiety of radical part and phenyl group of the chiral ligand.
Electrolyte Modulation Strategies for High Performance Zinc Batteries
Authors: Han Mingming , Li Tian Chen , Li Dong‐Sheng , Yang Hui Ying 
Published: March 2023

AbstractWith high safety and low‐cost features, aqueous zinc batteries have become the promising rechargeable battery technology for future. Recent research works reached a deep understanding on the underlying electrolyte chemistry in Zn batteries. This review aims to put forward the challenges that the aqueous electrolyte is facing, which include low voltage window, multifarious irreversible reactions, and low energy density. The innovative electrolyte modulation strategies, such as hybrid/concentrated solution, gel polymer electrolyte (hydrogel electrolyte), eutectic mixture, electrolyte additives, towards better zinc batteries performance are summarized. The conclusion and outlook are introduced to provide guidance for smart design of electrolyte for advanced Zn batteries.
Epigenetic rejuvenation by partial reprogramming
Authors: Puri Deepika , Wagner Wolfgang 
Published: March 2023

AbstractRejuvenation of cells by reprogramming toward the pluripotent state raises increasing attention. In fact, generation of induced pluripotent stem cells (iPSCs) completely reverses age‐associated molecular features, including elongation of telomeres, resetting of epigenetic clocks and age‐associated transcriptomic changes, and even evasion of replicative senescence. However, reprogramming into iPSCs also entails complete de‐differentiation with loss of cellular identity, as well as the risk of teratoma formation in anti‐ageing treatment paradigms. Recent studies indicate that partial reprogramming by limited exposure to reprogramming factors can reset epigenetic ageing clocks while maintaining cellular identity. So far, there is no commonly accepted definition of partial reprogramming, which is alternatively called interrupted reprogramming, and it remains to be elucidated how the process can be controlled and if it resembles a stable intermediate state. In this review, we discuss if the rejuvenation program can be uncoupled from the pluripotency program or if ageing and cell fate determination are inextricably linked. Alternative rejuvenation approaches with reprogramming into a pluripotent state, partial reprogramming, transdifferentiation, and the possibility of selective resetting of cellular clocks are also discussed.
Global prevalence and trend of anxiety among graduate students: A systematic review and meta‐analysis
Authors: Chi Ting , Cheng Luying , Zhang Zhijie 
Published: March 2023

AbstractObjectiveTo evaluate the comprehensive prevalence of anxiety among postgraduates and estimate its changes with a meta‐analysis.MethodSystematic retrieval to SAGE, ERIC, EBSCO, Wiley, ScienceDirect, ProQuest, PubMed, EMBASE, and Web of Science database was performed for quantitative studies on the prevalence of anxiety among graduate students published before November 22, 2022. The prevalence of anxiety synthesized with random‐effects model, and subgroup analysis was conducted by study characteristics (publication year, sampling method, and measurements) and subjects’ characteristics (gender, region, and educational level).ResultFifty studies were included in the meta‐analysis, totaling 39,668 graduate students. The result revealed that 34.8% of graduates suffered from the anxiety (95% CI: 29.5%–40.5%). Specifically, 19.1% (95% CI: 15.4%–23.5%) had mild anxiety, 15.1% (95% C: 11.6%–19.6%) had moderate anxiety, and 10.3% (95% CI: 7.2%–14.6%) had severe anxiety. And this prevalence showed a upward trend since 2005. Besides, master students suffered slightly less than doctoral students (29.2% vs. 34.3%), and female had similar anxiety to male (26.4% vs. 24.9%). Due to the COVID‐19, the prevalence of anxiety is higher after the pandemic than that before (any anxiety: 34.3% vs. 24.8%). Compared with other countries, students from Saudi Arabia, India, and Nepal were more vulnerable. The results of quality assessment showed that, 5 (10%) were in high quality, 21 (42%) were in moderate to high quality, 21 (42%) were in low to moderate quality, and 3 (6%) were in low quality. But, the studies with low quality tend to report a higher prevalence than that with high quality (40.3% vs. 13.0%), studies with nonrandom sampling tend to report a higher prevalence than that with random sampling (33.6% vs. 20.7%). Although we included the data collected based on the standard scales, there were higher heterogeneity among the measure (Q = 253.1, df = 12, p < .00).ConclusionMore than one‐third postgraduates suffered from anxiety disorder, and this prevalence had a slight upward trend since 2005, school administrators, teachers and students should take joint actions to prevent mental disorder of graduates for deteriorating.
Split and join: An efficient approach for simulating stapled intestinal anastomosis in virtual reality
Authors: Qi Di , De Suvranu 
Published: March 2023

AbstractColorectal cancer is a life‐threatening disease. It is the second leading cause of cancer‐related deaths in the United States. Stapled anastomosis is a rapid treatment for colorectal cancer and other intestinal diseases and has become an integral part of routine surgical practice. However, to the best of our knowledge, there is no existing work simulating intestinal anastomosis that often involves sophisticated soft tissue manipulations such as cutting and stitching. In this paper, for the first time, we propose a novel split and join approach to simulate a side‐to‐side stapled intestinal anastomosis in virtual reality. We mimic the intestine model using a new hybrid representation—a grid‐linked particles model for physics simulation and a surface mesh for rendering. The proposed split and join operations handle the updates of both the grid‐linked particles model and the surface mesh during the anastomosis procedure. The simulation results demonstrate the feasibility of the proposed approach in simulating intestine models and the side‐to‐side anastomosis operation.
Comparative Study on Chemical Composition of Green and Black Table Olives Brines of the Endemic ′′Sigoise′′ Cultivar: Recovery of high‐Added Values Compounds
Authors: Mohamadi Nadia , Meraghni Messaouda , Necib Asma , Jelaiel Loubna , El Arbi Mehdi , Bouaziz Mohamed 
Published: March 2023

AbstractThe effluents derived from the processing of table olives stand for a serious environmental problem. The study aims to valorize the brine water of table olives at different stages of ripening (green and black) of the Algerian variety Sigoise of Bejaia (East) and Mascara (West). The physico‐chemical characterization revealed that these samples display have a high acid pH and salinity. The comparative study of phenolic levels exhibited showed very significant differences between the brine waters of green olives from Bejaia and Mascara, while the brines of black olives presented showed comparable levels. A high strong antioxidant potential was confirmed by DPPH (CI50=0.35 μg/100 ml–0.50 μg/100 ml) and FRAP (CI50=626.89 μg/100 ml–875.54 μg/100 ml) tests. Chemical screening by HPLC‐DAD of the four samples identified high concentrations of hydroxytyrosol (HT) (390.4 mg/100 ml–360.8 mg/100 ml) and tyrosol (202.2 mg/100 ml–101.4 mg/100 ml). This study provided a deeper insight into the phenolic profile and the antioxidant potential of these brines.
Cancer‐associated fibroblasts: Is it a key to an intricate lock of tumorigenesis?
Authors: Aden Durre , Zaheer Sufian , Ahluwalia Himani , Ranga Sunil 
Published: March 2023

AbstractThe past few decades have witnessed a major leap in knowledge relating to the role of tumor microenvironment (TME) in carcinogenesis and evolving behavior of the tumor. Multiple factors within the TME modulate the cancer cells and the associated therapies. Stephen Paget first asserted that the microenvironment plays an important role in the growth of tumor metastasis. The most important player in the TME is cancer‐associated fibroblast (CAF) which significantly participates in the proliferation, invasion, and metastasis of tumor cells. CAFs show phenotypic and functional heterogeneity. Mostly CAFs originate from quiescent resident fibroblast or mesoderm‐derived precursor cells (mesenchymal stem cells), although several alternate sources of origin have been noted. However, due to lack of specific fibroblast‐restricted markers, it is very difficult to trace lineage and identify the biological origin of distinct subtypes of CAFs. CAFs are predominantly shown by several studies to mainly act as tumor‐promoting agents, however, tumor‐inhibiting actions are also being validated by several studies. A more objectified and comprehensive functional and phenotypic classification of CAF is required, which will help in better way for tumor management. Here, in this review, we have tried to review the current status of CAF origin, along with phenotypic and functional heterogeneity, and recent progress in CAF research.
Catalysis in Latin America
Authors: Zanchet Daniela , García Juventino J. , Baldovino Medrano Víctor Gabriel 
Published: March 2023

AbstractThis collection of papers from Latin American catalytic researchers was born from online interaction during the trialing times of the COVID‐19 pandemic. The collection showcases the diversification that the field of catalysis has had in our region and features works from Argentina, Brazil, Chile, Colombia, Mexico, and Venezuela, as well as contributions from Latin American researchers who have developed their careers abroad.
PROTOCOL: Treatment for depressive disorder among adults: An evidence and gap map of systematic reviews
Authors: Guo Liping , Li Jieyun , White Howard , Xu Zheng , Ren Junjie , Huang Xinyu , Chen Yaogeng , Yang Kehu 
Published: March 2023

AbstractThis is the protocol for a Campbell evidence and gap map. The objective of the map is to map available systematic reviews on the effectiveness of treatments for depressive disorders among adults. Specifically, this EGM includes studies on the effectiveness of treatments across a range of outcome domains.
How does entrepreneurial orientation influence firm performance? The roles of corporate social responsibility and institutional environments
Authors: Sheng Lixin , Gu Jibao , Wu Jianlin 
Published: March 2023

AbstractA growing number of firms are realizing that entrepreneurial orientation (EO) is an effective means to cope with competition and maintain sustainable growth. However, with the results of extant studies on EO‐performance relationship are not fully consistent, the potential mechanism about how EO influences firm performance needs to be further explored. Accordingly, this research investigates the mediating mechanism of EO‐performance by considering the role of corporate social responsibility (CSR) from the resource dependence perspective. In addition, we assess the relationship between EO and CSR by examining the moderating roles of institutional support and dysfunctional competition. Using the sample data of 214 Chinese firms to test the hypotheses, we find that CSR mediates the relationship between EO and firm performance. Moreover, institutional support negatively moderates the EO‐CSR relationship and dysfunctional competition positively moderates the relationship between EO and CSR. Based on the above results, our study provides practical implications for entrepreneurial firms striving to translate their EO into superior firm performance.
An adaptive heuristic algorithm to solve the network slicing resource management problem
Authors: Chen Yen‐Hung 
Published: March 2023

SummaryArtificial intelligence‐based (AI‐based) network slicing bandwidth allocation enables the 5G/6G service providers to create multiple virtual networks atop a shared physical infrastructure while fulfilling varying end‐user demands. Some researchers argue that AI‐enable network may run the danger of having private information compromised. We still need a backup rule‐based methodology to allocate bandwidth resource to each slice, if the AI‐based method suddenly encounters security issues. To design such a rule‐based methodology, this study attempts to answer two questions: (1) Is the network slicing bandwidth allocation problem the nondeterministic polynomial‐time completeness (NP‐completeness)? (2) Is there a heuristic methodology without any training process, which has equivalent performance compared to the AI‐based methodology? This study first proves the classical network slicing bandwidth allocation problems is NP‐completeness. This shows that the designed heuristic method is inescapably suboptimal to the network slicing bandwidth allocation problem. Secondly, this study proposes the Adaptive Hungarian Algorithm (AHA), which outperforms previous AI‐empowered method and does not need any training process. The experiments demonstrate that AHA reached 93%–97% of the maximal system throughput by brute‐and‐force algorithm, compared to other methodologies only having at most 93% of the maximal system throughput. This also indicates that AHA is capable to solve the network slicing bandwidth allocation problem, if the telecommunication operators do not have sufficient sample complexity to train an AI model.