bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rice blast-induced jasmonic acid signal transduction affects rice resistance against brown planthopper by regulating the flavonoid biosynthesis pathway
Authors: Chen Su , Shen Yanjie , Tao Zhihuan , Chen Zixu , Yang Rui , Yan Siyuan , Sun Bo , Yang Xiaofang 
Published: September 2023

Abstract
The complex interactions among plants, herbivorous insects, and microbes form an iron triangle in nature, and even a minor alteration in any of these components can trigger a chain of interconnected reactions. In our study on the interaction between rice plants, brown planthopper (BPH), and rice blast fungus, we discovered that the resistance of rice treated with rice blast to BPH was significantly increased. Transcriptomic and mass spectrometric results showed that rice blast fungus treatment induced the contents of eriodictyol, naringenin, quercetin, as well as the expression of most genes in the flavonoid biosynthesis pathway except OsF3'H. Correspondingly, OsF3′H knockout lines enhanced rice resistance to BPH. OsMYC2 is a core transcription factor in the jasmonic acid (JA) signaling pathway and rice blast fungus induced the expression of OsMYC2, OsMYC2 knockout lines reduced rice resistance to BPH. Furthermore, a series of experiments demonstrated that OsMYC2 has a transcriptional repressive effect on OsF3'H. Overall, we revealed the phenomena and reasons behind the increased resistance to BPH after treating rice with rice blast fungus in terms of histological data, experimental phenotypes, and gene expression, respectively. This will deepen our understanding of the interactions among rice, rice fungus and BPH, and provide theoretical support for ecological management.
Developments of a centimeter-level precise muometric wireless navigation system (MuWNS-V) and its first demonstration using directional information from tracking detectors
Authors: Varga Dezső , Tanaka Hiroyuki K. M. 
Published: September 2023

Abstract
Various positioning techniques such as Wi-Fi positioning system have been proposed to use in situations where satellite navigation is unavailable. One such system, the muometric positioning system (muPS), was invented for navigation which operates in locations where even radio waves cannot reach such as underwater or underground. muPS takes advantage of a key feature of its probe, cosmic-ray muons, which travel straightforwardly at almost a speed of light in vacuum regardless of the matter they traverse. Similar to other positioning techniques, muPS is a technique to determine the position of a client's muPS receiver within the coordinate defined by reference detectors. This can be achieved either by using time-of-flight (ToF) or angle of arrival (AoA) measurements. The latter configuration (AoA), called the Vector-muPS has recently been invented and the present paper describes the developments of the first prototype of a vector muometric wireless navigation system (MuWNS-V) with this new vector-muPS concept and its demonstration. With MuWNS-V, the reference tracker and the receiver ran wirelessly with fully independent readout systems, and a positioning accuracy of 3.9 cm (RMS) has been achieved. We also evaluated the outcome of measuring continuous indoor localization of a moving receiver with this prototype. Our results indicated that further improvements in positioning accuracy will be attainable by acquiring higher angular resolution of the reference trackers. It is anticipated that "sub-cm level" navigation will be possible for muPS which could be applied to many situations such as future autonomous mobile robot operations.
Novel Identification Method for Demodex Viability in Human Eyes
Authors: Niu Qing , Cai Shiyuan , Hu Yuxuan , Geng Yuqian , Yang Cici , Yu Wenying , Liu Yi 
Published: September 2023

Abstract
Background
The current treatments cannot kill the mites, hence the need to evaluate optimal culture conditions for demodex mites in vitro and explore specific drugs for demodicosis.
Objective
Using a new method to identify the viability of Demodex folliculorum for screening clinically relevant drugs more accurately.
Methods
We compared the autofluorescence changes of demodex in a tea tree oil preparation (TTO preparation) and PBS buffer. Using the propidium fluorescent dye, the fluorescence intensity was measured using the Image-J software.
Results
In the two experimental groups, the diffusion speed of demodex's own blue fluorescence combined with joint ganglion in the PBS group was slower than that in the TTO preparation group, and the stability time of the whole body blue fluorescence was longer. The fluorescence peak value of PI stained red fluorescence was lower than that of TTO preparation group, and the staining fluorescence value required longer stability time, with lower fluorescence intensity at stabilization, which was consistent with expectations.
Limitations:
Fewer types of demodex culture media were selected for the experiment.
Conclusion
This novel demodex mite viability identification method objectively and effectively screens demodex-related drugs and can provide an effective reference for subsequent drug screening and evaluation.
The Space to Depth Convolution bundled with Coordinate Attention for detecting surface defects
Authors: Wan Wenqian , Wang Lei , Wang Bingbing , Yu Haoyang , Shi Kuijie , Liu Gang 
Published: September 2023

Abstract
Surface defects of steel plates unavoidably exist during the industrial production proceeding due to the complex productive technologies and always exhibit some typical characteristics, such as irregular shape, random position, and various size. Therefore, detecting these surface defects with high performance is crucial for producing high-quality products in practice. In this paper, an improved network with high performance based on You Only Look Once version 5 (YOLOv5) is proposed for detecting surface defects of steel plates. Firstly, the Space to Depth Convolution (SPD-Conv) is utilized to make the feature information transforming from space to depth, helpful for preserving the entirety of discriminative feature information to the greatest extent under the proceeding of down-sampling. Subsequently, the Coordinate Attention (CA) mechanism is introduced and embedded into the bottleneck of C3 modules to effectively enhance the weights of some important feature channels, in favor of capturing more important feature information from different channels after SPD-Conv operations. Finally, the Spatial Pyramid Pooling Faster (SPPF) module is replaced by the Spatial Pyramid Pooling Fully Connected Spatial Pyramid Convolution (SPPFCSPC) module to further enhance the feature expression capability and efficiently realize the multi-scale feature fusion. The experimental results on NEU-DET dataset show that, compared with YOLOv5, the mAP and mAP50 dramatically increase from 51.7%, 87.0–61.4%, 92.6%, respectively. Meanwhile, the frame rate of 250 FPS implies that it still preserves a well real-time performance. Undoubtedly, the improved algorithm proposed in this paper exhibits outstanding performance, which may be also used to recognize the surface defects of aluminum plates, as well as plastic plates, armor plates and so on in the future.
Efficacy of Various Extracting Solvents on Phytochemical Composition, Antioxidant Potential, Total Phenolic Content, and Antibacterial Properties, of Moroccan Mentha longifolia L. Leaf Extracts against Multidrug-Resistant Pathogenic Bacteria
Authors: Tourabi Meryem , Metouekel Amira , ghouizi Asmae EL , Jeddi Mohamed , Nouioura Ghizalne , Laaroussi Hassan , hosen Md. eram , Benbrahim Kawtar Fikri , Bourhia Mohammed , Salamatullah Ahmad Mohammad , Nafidi Hiba-Allah , Wondmie Gezahign Fentahun , Lyoussi Badiaa , Derwich El Houssine 
Published: September 2023

Abstract
The current work attempts to explore the influence of three extraction solvents on phytochemical composition, content of polyphenols, antioxidant potential, and antibacterial capacity of Moroccan Mentha longifolia L. leaves hydroethanolic, acetonic, and water extracts. To achieve this goal, the chemical composition was identified using an HPLC-DAD examination. The contents of polyphenolswere assessed, while the total antioxidant capacity (TAC), the DPPH test, and the reducing power test (RP) were utilized to determine antioxidant capacity. To assess the antibacterial activity, the microdilution technique was carried out to calculate the minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) ofextracts against four nosocomial bacteria (Bacillus cereus, Pseudomonas aeruginosa, Escherichia coli, andStaphylococcus aureus).Additionally, the antibacterial and antioxidant activities of all tested extracts were examined in silico against the proteins NADPH oxidaseand Bacillus cereusphospholipase C. Study reveals M. longifolia extracts contain high phenolicand flavonoids.Additionally, the hydroethanolic extract contained the highest amounts of phenolic and flavonoid content, with values of 23.52 ± 0.14 mg GAE/g DW and 17.62 ± 0.36 mg QE/g DW, respectively comparedto the other two extracts. The same extract showed the best antioxidant capacity(IC50 = 39 µg/mL ± 0.00), and the higher RP (EC50 of 0.261 ± 0.00 mg/mL), compared to the acetonic and water extractregarding these tests. Furthermore, the hydroethanolic and acetonic extracts expressed the highest TAC (74.40 ± 1.34, and 52.40 ± 0.20 mg EAA/g DW respectively), compared withthe water extract. Regarding antibacterial activity, the MIC value ranges between 1.17and 12.50 mg/mL. The in-silico results showed that the antibacterial activity of all extracts is principally attributed to kaempferol and ferulic acid, while antioxidant capacity is attributed to ferulic acid.
Supplement Use and Its Impact on Daily Life of Cancer Patients: A Cross Sectional Study
Authors: Toum Youssef El , Costa Tarek , Toum Elissa El , Haddad Tina , Salameh Pascale , Elkarak Fady , Ghosn Marwan , Nasr Fady , Chahine Georges , Kattan Joseph , Kourie Hampig Raphael 
Published: September 2023

Abstract
Purpose
This cross-sectional study aimed to investigate the prevalence and characteristics of supplement usage among cancer patients and explore its potential associations with anxiety, excessive daytime sleepiness, and overall quality of life.
Methods
Cancer patients receiving specific care at Hôtel Dieu de France University Hospital, Beirut, were enrolled between April and June 2023. In face-to-face interviews, participants were asked to complete a questionnaire consisting of sociodemographic information, supplement usage details, and cancer-related variables. Three validated surveys (Epworth Sleepiness Scale, GAD-7 and EORTC-QLQ-C15-PAL) were employed to assess excessive daytime sleepiness, anxiety and overall quality of life. Statistical analyses, including chi-square tests, t-tests, and multiple regression models, were conducted to examine associations between supplement use and other variables.
Results
202 participants were interviewed. 52% reported regular use of supplements following their cancer diagnosis, with vitamin D being the most commonly used supplement. Using multivariate logistic regression, supplement use was associated with being female, having lower educational levels, having a longer duration since cancer diagnosis and having a poor overall quality of life. The multivariate logistic regression showed no significant correlation between supplement use and excessive datime sleepiness and anxiety.
Conclusion
This study highlights a high prevalence of supplement usage among cancer patients in Lebanon, indicating a rising interest in alternative therapies aimed at enhancing quality of life. Larger prospective studies are needed to assess the relation between supplement intake and excessive daytime sleepines and anxiety and establish clear guidelines pertaining to supplement use in cancer patients.
Acoustic characteristics of voice production in virtual reality-simulated and physical environments. A comparative study in university professors
Authors: Rodríguez Daniel , Borrego Adrián , Guzmán Marco , Llorens Roberto 
Published: September 2023

Abstract
Purpose
This study investigated the reliability of a virtual reality-simulated classroom to generate a comparable self-perception of voice quality and acoustic effects of phonation to a real classroom in a group of teachers, and sense of presence.
Method
Thirty university professors participated in the study and were required to produce loud connected speech by reading a 100-word text in two conditions: (1) in a real classroom including a group of students, and (2) in a virtual replica of the classroom consisting of a 360-degree video of the same classroom and students, which was displayed using a head mounted display. Ambient noise was controlled in both conditions by playing classroom noise through headphones. The self-perception of voice quality, the long-term average spectrum and smooth cepstral peak prominence were estimated in both conditions. The sense of presence generated by virtual reality was measured after interacting with the virtual classroom.
Results
There were no statistically significant differences in the self-perception of voice quality or in the acoustic measures of voice production between conditions. The sense of presence in the virtual classroom was high.
Conclusions
Our findings suggest that a virtual reality-simulated classroom generate comparable self-perception of voice quality and acoustic effects of phonation to the real classroom, and a high sense of presence, in a group of teachers. Additionally, it is important to highlight the potential of virtual reality to enhance the ecological validity of acoustic assessment of voice production in laboratories and clinical settings.
Physical activity can reduce the risk of blood cadmium and blood lead on stroke: Evidence from NHANES
Authors: deng xiaoqi , Liu Dichuan , Li Miao , He Jie , Fu Yufan 
Published: September 2023

Abstract
Objectives
The detrimental impact of heavy metals on cardiovascular well-being is a global concern, and engaging in suitable physical activity has been shown to confer cardiovascular advantage. Nevertheless, the potential of exercise to mitigate the deleterious effects of heavy metals on stroke remains uncertain.
Methods
We conducted a cross-sectional survey to assess the influence of blood cadmium and blood lead on stroke occurrence, while also examining the role of physical activity. Weighted multivariate regression analysis was employed to examine the potential correlation, while subgroup and interaction analyses were used to investigate the sensitivity and robustness of the results.
Results
After controlling risk factors, it revealed a positive correlation between blood cadmium and lead levels and the occurrence of stroke. Specifically, a 50% increase in blood cadmium was associated with a 28% increase in stroke incidence, while a 50% increase in blood lead was associated with a 47% increase in stroke incidence. To estimate the non-linear relationship, we employed restricted cubic models. The results demonstrate a gradual decrease in the slope of the model curve as the intensity of physical activity increases, implying that engaging in physical activity may contribute to a reduction in the occurrence of stroke caused by blood cadmium and lead.
Conclusions
Our findings suggest that blood cadmium and lead could be considered an autonomous risk factor for stroke within the general population of the United States. Moreover, engaging in physical activity has the potential to mitigate the potential detrimental consequences associated with exposure to heavy metals.
Risk of Second Primary Malignancy after Surgery or Definitive Radiotherapy for Early-Stage Head and Neck Squamous Cell Carcinoma: A Population-based Study
Authors: Lin Hanqing , Wu Xiaobo , Yao Guangnan , Xu Yuanteng , Lin Chang 
Published: September 2023

Abstract
Background
The primary treatment modalities for patients with early-stage head and neck squamous cell carcinoma (HNSCC) predominantly include surgical resection and definitive radiotherapy (RT). However, RT may increase the risk of second primary malignancy (SPM) in cancer patients. This study aimed to investigate the association between treatment modalities and SPM risk in early-stage HNSCC patients.
Methods
Data of 5-year survivors of early-stage (stage I-II, 7th AJCC staging manual) HNSCC from 2000 to 2020 was extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Standardized incidence ratio (SIR) and excess absolute risk (EAR) were used to assess SPM development externally. Relative risk (RR) was estimated to compare SPM risk within treatment groups. Fine-Gray's competing risk model was applied to estimate cumulative SPM incidence after the diagnosis of index early-stage HNSCC.
Results
The study included 8957 5-year survivors with early-stage HNSCC. Patients who received definitive RT had poorer long-term survival compared to those who underwent surgical resection. Surgical resection was associated with a lower SPM risk (RR = 0.89, 95% CI 0.80–0.99), particularly in patients with primary oropharyngeal squamous cell carcinoma (RR = 0.56, 95% CI 0.39–0.82). Differences in the risk of SPM development among subgroups based on clinical characteristics were not significant. Treatment modalities did not significantly affect SPM risk within each subgroup.
Conclusions
Surgical treatment in early-stage HNSCC patients was associated with better overall survival and a lower risk of SPM compared to definitive RT. SPM incidence and sites varied among different primary sites, emphasizing the importance of targeted long-term follow-up surveillance.
FDANet: A frequency-domain attention network for super-resolution image quality assessment
Authors: Fan Dandan , Li Hui , Zhang Kaibing , Shi Guang 
Published: September 2023

Abstract
No-reference super-resolution image quality assessment (NR-SRIQA) is still a challenging task due to complicated degradation factors and the lack of reference high-resolution (HR) images. In this paper, we propose a novel NR-SRIQA framework that elaborately designs a frequency domain attention lightweight network called FDANet to predict the quality of SR images. Firstly the frequency domain attention module is used to extract the frequency domain salient map from the divided image patches, and then a frequency domain attention lightweight network is used as the backbone to learn the features in SR images to improve the performance of the network. Compared with the spatial domain attention module, the proposed frequency domain attention module is conducive to learn quality-aware features to quantify the quality of SR images. By integrating the deep learning-based features, the proposed NR-SRIQA model facilitates more compelling quality prediction but requires obviously less computational cost in contrast to compared deep networks for NR-SRIQA. Experimental results verify the superior performance of our method on two benchmark data-bases in terms of both quantitative evaluations and thorough analysis on the model deployment.
Modeling, prediction and suggestions of the amount of domestic waste clearance in Shenzhen using an optimized high- performance grey model
Authors: Zeng Bo , Xia Chao , Yang Yingjie 
Published: September 2023

Abstract
As a leading economic center in China and an international metropolis, Shenzhen has great significance in promoting sustainable urban development. To predict its amount of domestic waste clearance, a new multivariable grey prediction model with combinatorial optimization of parameters is established in this paper. Firstly, the new model expands the value range of the order r of a grey accumulation generation operator from positive real numbers (R+) to all real numbers (R), which enlarges the optimization space of parameter and has positive significance for improving model performance. Secondly, the dynamic background-value coefficient λ is introduced into the new model to improve the smoothing effect of the nearest neighbor generated sequences. Thirdly, the Particle Swarm Optimization (PSO) is employed to optimize parameters r and λ to improve the overall performance of the new model. The new model is used to simulate and predict the amount of domestic waste clearance in Shenzhen, and the comprehensive error of the new model is only 0.27%, which is far superior to several other similar models. Lastly, the new model is applied to predict the amount of domestic waste clearance in Shenzhen. The results indicate the amount of domestic waste clearance in 2028 could be 9.96 million tons, an increase of 20.58% compared to 2021.This highlights the significant challenge that Shenzhen faces in terms of urban domestic waste treatment. Therefore, some targeted countermeasures and suggestions have been proposed to ensure the sustainable development of Shenzhen's economy and society.
The role of ApoE on fatty acid transport from neurons to astrocytes under ischemia/hypoxia conditions
Authors: Chen Hongyan , Zhao Shaozhi , Qiang Jian , Yinfang Yan , Simin Wang , Zhang Xinwen , Yuqiang Ji 
Published: September 2023

Abstract
Background
The aim of this study was to investigate whether ischemia/hypoxia conditions induce fatty acid transport from neurons to astrocytes and whether this mechanism is affected by ApoE isoforms.
Methods and Results
A neonatal rat model of hypoxic-ischaemic brain damage was established. Excessive accumulation of lipid droplets and upregulation of ApoE expression occurred in the hippocampus and cerebral cortex after hypoxic-ischaemic, which implied the occurrence of abnormal fatty acid metabolism. Lipid peroxidation was induced in the oxygen-glucose deprivation and reperfusion (OGDR) model of ApoE−/− primary neurons. The number of BODIPY 558/568 C12-positive particles (fatty acid markers) transferred from neurons to astrocytes was significantly increased with the addition of human recombinant ApoE compared with the OGDR group, which significantly increased the efficiency of fatty acid transport from neurons to astrocytes and neuronal viability. However, ApoE4 was found to be associated with lower efficiency in fatty acid transport and less protective effects in OGDR caused neuronal cell death than both ApoE2 and ApoE3. COG133, an ApoE-mimetic peptide, partially compensated for the adverse effects of ApoE4. FABP5 and SOD1 gene and protein expression levels were upregulated in astrocytes treated with BODIPY 558/568 C12 particles.
Conclusions
In conclusion, ApoE plays an important role in mediating the transport of fatty acids from neurons to astrocytes under the ischemia/hypoxia conditions, and this transport mechanism is ApoE isoform dependent. ApoE4 has a low transfer efficiency and may be a potential target for the clinical treatment of neonatal hypoxic-ischaemic encephalopathy.