bluuebunny/crossref_metadata_2025_split huggingface dataset:
KECEMASAN LANJUT USIA DALAM MENGHADAPI MASA DEPERSONALISASI
Authors: Manurung Faisal Akbar , Hapni Elida , Dasril Dasril 
Published: June 2023

Penelitian ini mengenai kecemasan lanjut usia dalam menghadapi masa depersonalisasi, dimana lanjut usia di Kelurahan WEK I merasakan kecemasan dalam menghadapi kematian. Lanjut usia mengalami penurunan daya imunitas tubuh akibat kecemasan dalam menghadapi masa depersonalisasi berupa ketakutan dalam menghadapi kematian. Dan jenis kecemasan lanjut usia dalam menghadapi masa depersonalisasi di Kelurahan WEK I Kecamatan Padangsidimpuan Utara dan Bagaimana dampak kecemasan lanjut usia dalam menghadapi masa depersonalisasi di Kelurahan WEK I Kecamatan Padangsidimpuan Utara. Penelitian kualitatif deskriptif adalah penelitian yang peneliti gunakan, dengan menggunakan pendekatan fenomenologi. Adapu metode pengumpulan data yang dilakukan yakni melalui wawancara, observasi dan dokumentasi. Sumber data primer dalam penelitian ini adalah lanjut usia yang berusia 60-75 tahun, sedangkan sumber data sekundernya adalah keluarga yang tinggal bersama lanjut usia, tetangga, warga masyarakat dan lurah. Hasil penelitian yaitu jenis kecemasan lanjut usia dalam menghadapi masa depersonalisasi di Kelurahan WEK I Kecamatan Padangsidimpuan Utara menjadi 3 yaitu; kecemasan superego, kecemasan neurotis dan kecemasan psikotis. Lanjut usia yang mengalami kecemasan yang paling banyak adalah kecemasan psikis yaitu sebanyak 5 lanjut usia dengan persentase 50% sedangkan untuk kecemasan superego dan kecemasan neurotis sebanyak 3 lanjut usia atau 30%. Dimana individu yang berada pada fase usia lanjut mengalami masa depersonalisasi di Kelurahan WEK I Kecamatan Padangsidimpuan Utara menjadi 2 yaitu dampak positif dan dampak negatif. Dampak positif yaitu: religius, sabar dan berkumpul dengan keluarga. Sedangkan dampak negatifnya yaitu: suasana hati, pikiran dan perilaku. Dampak positif terlihat lebih banyak dari lanjut usia yang mengalami dampak religius dan sabar masing-masing 4 orang atau dengan persentase 40% sedangkan untuk dampak berkumpul dengan keluarga sebanyak 3 lanjut usia atau 30%. Sedangkan untuk dampak negatif terlihat lebih banyak dari lanjut usia yang mengalami dampak suasana hati dan perilaku masing-masing 4 orang atau dengan persentase 40% sedangkan untuk dampak pikiran dengan keluarga sebanyak 3 orang lanjut usia atau 30%.
Vessel wall imaging and carotid artery stenting for recurrent cervical internal carotid artery vasospasm syndrome: illustrative case
Authors: Tokunaga Shinya , Yamao Yukihiro , Maki Takakuni , Ishii Akira , Miyake Tomoaki , Yasuda Ken , Abekura Yu , Okawa Masakazu , Kikuchi Takayuki , Fushimi Yasutaka , Yoshida Kazumichi , Miyamoto Susumu 
Published: June 2023

BACKGROUND
Recurrent cervical internal carotid artery vasospasm syndrome (RCICVS) causes cerebral infarction, ocular symptoms, and occasionally chest pain accompanied by coronary artery vasospasm. The etiology and optimal treatment remain unclear.

OBSERVATIONS
The authors report a patient with drug-resistant RCICVS who underwent carotid artery stenting (CAS). Magnetic resonance angiography revealed recurrent vasospasm in the cervical segment of the internal carotid artery (ICA). Vessel wall imaging during an ischemic attack revealed vascular wall thickening of the ICA, similar to that in reversible cerebral vasoconstriction syndrome. The superior cervical ganglion was identified at the anteromedial side of the stenosis site. Coronary artery stenosis was also detected. After CAS, the symptoms of cerebral ischemia were prevented for 2 years, but bilateral ocular and chest symptoms did occur.

LESSONS
Vessel wall imaging findings suggest that RCICVS is a sympathetic nervous system-related disease. CAS could be an effective treatment for drug-resistant RCICVS to prevent cerebral ischemic events.
OBEZ HASTALARDA BEDEN KİTLE İNDEKSİ VE ATEROJENİK İNDEKSİN RETINAL MİKROVASKÜLER YAPI ÜZERİNE ETKİLERİ
Authors: İÇEL Erel , AKBAŞ Nergis , AKBAŞ Emin Murat , İÇEL Aykut , ARSLAN Yusuf Kemal 
Published: June 2023

Amaç: Bu çalışmada, obez hastalarda retinal mikrovasküler yapısında meydana gelen değişiklikleri değerlendirmeyi ve bu değişikliklerin klinik özelliklerle ilişkisini belirlemeyi amaçladık.
Gereç ve Yöntemler: Tüm katılımcılarda kolesterol, açlık kan şekeri, açlık insülini,CRP ve HbA1C düzeylerini içeren biyokimyasal incelemeler yapıldı. Plazma aterojenik indeksi(AI) plazma trigliserid (TG) düzeyinin yüksek yoğunluklu lipoprotein (HDL) düzeyine oranının logaritması [log (TG/HDL-K)] olarak hesaplandı. Vücut Kitle İndeksi (VKİ) ≤25 kg/m2 olan hastalar kontrol grubuna dahil edildi. Obez hastalar VKİ'lerine göre üç gruba ayrıldı: grup 1 (VKİ: 30-34,99 kg/m2), grup 2 (VKİ: 35-39.99 kg/m2) ve grup 3 (VKİ ≥ 40 kg/m2) . Optik koherens tomografi anjiografi (OKT-A) ile foveal avasküler zon (FAZ), makulada yüzeyel ve derin kapiller pleksusun damar dansitesi (VD) ile radial peripapiller kapiller pleksus VD ölçüldü.
Bulgular: Çalışmaya 27 kontrol ve 83 obez hasta olmak üzere toplam 110 hasta dahil edildi. Kontrol vakalarına kıyasla obez hastalarda HbA1C, açlık insülini, HOMA-IR, C-reaktif protein ve AI seviyeleri anlamlı derecede yüksekti. Obez hastalarda retinanın yüzeyel (p=0,003) ve derin (p=0,001)VD'leri anlamlı olarak azaldı ve FAZ anlamlı olarak arttı (p=0,032). Klinik özellikler ile OKT-A bulguları arasında yapılan korelasyon analizinde yüzeyel ve derin VD'ler yaş, VKİ, HbA1C ve AI ile ters orantılıydı.
Sonuç: Obez hastalarda retina yüzeyel ve derin VD'leri azalmıştı ve retinal VD'ler ile yaş, VKI, HbA1C ve AI arasında ters bir ilişki vardı.
Dis-locative Spaces and Digital Interactions
Authors: Sharifi Meraj 
Published: June 2023

The concept of space constantly is growing with the advancement of technology. The spatial interactions using digital media provide new possibilities to bridge between physical and digital spaces. Location is not all about longitude and latitude, but all the added digital layer which may change the idea of positioning. Over the last decades, space studies faced many conceptual perceptions. The approach of having/imagining the different worlds and spaces, such as cyberspace and physical space, has been mostly formed by distinguishing them. Adriana de Souza e Silva (2006) drew a chronology for these imaginary spaces from cyberspace to virtual and hybrid space. Hybridizing of space with the advancement of nomadic technology like mobiles become more popular and indicates how the interfaces are transparent in our everyday life. So, hybridity occurs when the interconnection of the spaces is accessible for the people who can interact with, through the devices, wearable, headsets, etc. In this respect, the physical space needed to be filled with data, as Manovich (2006, p.226) defined this as augmentation of the space through “overlay[ing] physical space with layers of data.”
The question of reality may not be valid anymore since both are affecting each other. And, maybe it is time to think about the interlinked worlds and their effects rather than separating and labelling them by real and unreal. Technology can play a crucial role in changing our interaction with space.
The paper will investigate the concept of hybrid spaces in relation to production of dis-locative space. The dislocation environment that reveals the interconnected spaces and their realities through new ways of interactions and narratives. The realities that are created under the influence of each other. The paper will use the art project Shadows from Another Place as a case study. It will explore the idea of dis-location through spatial interaction and digital technology. The paper will profit from the theories including Production of Space by Henry Lefebvre, Supermodernity and Non-places by Mark Augé, and Relational Spaces by Scott McQuire.
Paula Levine is a scholar and media artist who experiments with maps, geolocation data, and the dynamic of spaces. Shadows from Another Place is a web-based project using transposed maps, including three artworks San Francisco <-> Baghdad, The Wall, and TheWall-TheWorld. In this series, she tries to challenge the reality of geographical distances by hybridization of the spaces. Shadows from Another Place is a series of artwork that examines the discussion around dis-locative space, and spatial interaction using digital technology. The paper investigates with three questions of locations and dislocation, real and unreal, and intervening in the physical space by the virtual world and vice versa. Question of Location ‘where am I’? What is un/real? How virtual world affects physical world and vice versa?
Efficacy of Autologous Blood Clot in Primary Pterygium Excision Compared with Suture Technique
Authors: Tanzin Tanuja , Iqbal Md Iftekher 
Published: June 2023

Background: To assess the efficacy of pterygium excision and conjunctival autograft surgery among patients underwent autologous blood clot or using sutures (10-0 monofilament nylon).
Materials and methods: A randomized controlled trial was done at Department of Ophthalmology, Chittagong Medical College Hospital, with a study period from February 2017 to November 2018 was conducted with 60 eyes from 60 patients having primary nasal pterygium. They were selected according to inclusion and exclusion criteria and randomized into two groups for conjunctival autograft. Group A (30) was treated with autologous blood clot and Group B (30) was treated with sutures (10-0 monofilament nylon). All surgeries were performed by a single surgeon at single center. Standard examinations were performed preoperatively and postoperatively, preoperative and postoperative outcomes were evaluated and compared statistically where follow up was done at 1st day,7th days, 1-month, 3-month, and 6-month post operation. The mainoutcome variables were postoperative discomfort, graft stability and complications.
Results: This study included 60 patients (60 eyes) with a mean age of 46.77±7.04 (SD) (Range 33 to 58 years) in Group A (30) and 46.17±7.53 (SD) (Range 22 to 58 years) in Group B (30). In Group A, male was 22 (73.3%) and female was 8 (26.7%) where Group Bcontained male 20 (66.7%) and female 10 (33.3%). Follow-up at 1st and 7th post operation days showed marked discomfort in Group B (Mean rank 41.82 and 40.62) compared to Group A (Mean rank 19.18 and 20.38) respectively (p<0.001). At 1st post operation day there were 3 (10%) graft retraction in Group Aonly. Within 6 months follow-up, all grafts were stable and there wasonly 1 (3.3%) granuloma in Group B.
Conclusion: In primary pterygium excision, autologous blood clot showed excellent post- operative outcomes with much comfort, more stableas well as fewer complications. So, it appears to be an effective means to treat primary pterygium surgically.
JCMCTA 2020 ; 31 (1) : 42-47
Histomorphological Study of Nephrectomy Specimens in a Tertiary Care Hospital Of Chattogram: An Observational Study
Authors: Nasreen Sayeeda , Sadaf Anika , Ahamad Shahab Uddin , Rahman Md Zillur 
Published: June 2023

Background: Now a-days nephrectomy is not an uncommon surgery practiced in urology. Not only the clinical suspicions are confirmed but also many unsuspecting lesions are brought to light by the histopahological study.Elective nephrectomy is done for both benign and malignant diseases of the kidney. On the other hand, trauma is the most common cause of emergency nephrectomy. To observe the demographic and histopathological aspects of nephrectomy specimens in a tertiary care hospital of Chattogram: Chittagong Medical College Hospital.
Materials and methods: This was an observational study of nephrectomy specimens received in the Department of pathology, Chittagong Medical College over a period of one year (January to December 2019). The studied parameters were: frequency, age, sex, laterality, clinical presentation, histological type and morphologic characteristics.
Results: There were 30 nephrectomy specimens of which 09 were non-neoplastic and 21 were neoplastic lesions. Among the neoplastic lesions, all the cases were malignant with no significant side and sex differences of patients. The most frequent (26.67%) age rage was 0-10 year and renal cell carcinoma was the commonest (13 out of 21 cases, 61.90%) malignant tumor. Among the nonneoplastic lesions, chronic pyelonephritis was the most frequent benign lesion (5 out of 9 cases, 55.56%).
Conclusion: In this study, there was a much higher rate of nephrectomy performed for malignant conditions of the kidney compared to other developing countries, where benign lesions are the main cause of nephrectomies.
JCMCTA 2020 ; 31 (1) : 58-63
Edukasi Patient Safety pada Pasien dan Keluarga Pasien di Instalasi Poliklinik Rumah Sakit Umum Daerah Sayang Rakyat Kota Makassar
Authors: Rachmawaty Rini , Hamid Firdaus , Gaffar Indra , Tombong Andi Baso , Razak Poppy Nurul Asmaul , Angraini Fatima 
Published: June 2023

In 2019, data was obtained that there were 12 cases of Potential Injury Events (KPC) at RSUD Sayang Rakyat. Therefore, RSUD Sayang Rakyat is the target of Patient Safety Education activities for patients and their families at the Polyclinic. The aim of carrying out community service is to prevent and reduce risks, errors and losses that occur to patients during the provision of health services. This community service uses educational methods for polyclinic patients and families using video and flayers and is simulated directly to patients and families. Besides that, to measure patient and family understanding before education, they are given a pre-test and after education, it is given a post-test which consists of 6 multiple choice questions related to 6 patient safety goals in the hospital. The evaluation results obtained after 3 times of education showed significantly increased knowledge of patients and patient families compared to before education with values 0,529 (p= 0,041) in education 1, 0,8 (p=0,046) in education 2 and 0,692 (p=0,041) in education 3 it is hoped that hospitals will pay more attention to and improve patient safety in hospitals in order to prevent incidents to patients.
Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in Helicobacter pylori infection
Authors: Li Huan , Lin Jiahui , Cheng Sha , Chi Jingshu , Luo Ju , Tang Yu , Zhao Wenfang , Shu Yufeng , Liu Xiaoming , Xu Canxia 
Published: June 2023

Background:Helicobacter pylori (H.pylori) infection is an important factor in the occurrence of human gastric diseases, but its pathogenic mechanism is not clear. N6-methyladenosine (m6A) is the most prevalent reversible methylation modification in mammalian RNA and it plays a crucial role in controlling many biological processes. However, there are no studies reported that whether H. pylori infection impacts the m6A methylation of stomach. In this study, we measured the overall level changes of m6A methylation of RNA under H. pylori infection through in vitro and in vivo experiment.Methods: The total quantity of m6A was quantified in gastric tissues of clinical patients and C57 mice with H. pylori infection, as well as acute infection model [H. pylori and GES-1 cells were cocultured for 48 h at a multiplicity of infection (MOI) from of 10:1 to 50:1]. Furthermore, we performed m6A methylation sequencing and RNA-sequencing on the cell model and RNA-sequencing on animal model.Results: Quantitative detection of RNA methylation showed that H. pylori infection group had higher m6A modification level. M6A methylation sequencing identified 2,107 significantly changed m6A methylation peaks, including 1,565 upregulated peaks and 542 downregulated peaks. A total of 2,487 mRNA was upregulated and 1,029 mRNA was downregulated. According to the comprehensive analysis of MeRIP-seq and RNA-seq, we identified 200 hypermethylation and upregulation, 129 hypermethylation but downregulation, 19 hypomethylation and downregulation and 106 hypomethylation but upregulation genes. The GO and KEGG pathway analysis of these differential methylation and regulatory genes revealed a wide range of biological functions. Moreover, combining with mice RNA-seq results, qRT- PCR showed that m6A regulators, METTL3, WTAP, FTO and ALKBH5, has significant difference; Two key genes, PTPN14 and ADAMTS1, had significant difference by qRT- PCR.Conclusion: These findings provide a basis for further investigation of the role of m6A methylation modification in H. pylori-associated gastritis.
Potential interaction between the oral microbiota and COVID-19: a meta-analysis and bioinformatics prediction
Authors: Tan Li , Zhong Meng-Mei , Liu Qiong , Chen Yun , Zhao Ya-Qiong , Zhao Jie , Dusenge Marie Aimee , Feng Yao , Ye Qin , Hu Jing , Ou-Yang Ze-Yue , Zhou Ying-Hui , Guo Yue , Feng Yun-Zhi 
Published: June 2023

ObjectivesThe purpose of this study was to evaluate available evidence on the association between the human oral microbiota and coronavirus disease 2019 (COVID-19) and summarize relevant data obtained during the pandemic.MethodsWe searched EMBASE, PubMed, and the Cochrane Library for human studies published up to October 2022. The main outcomes of the study were the differences in the diversity (α and β) and composition of the oral microbiota at the phylum and genus levels between patients with laboratory-confirmed SARS-CoV-2 infection (CPs) and healthy controls (HCs). We used the Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA) database, Protein−protein interaction (PPI) network (STRING) and Gene enrichment analysis (Metascape) to evaluate the expression of dipeptidyl peptidase 4 (DPP4) (which is the cell receptor of SARS CoV-2) in oral tissues and evaluate its correlation with viral genes or changes in the oral microbiota.ResultsOut of 706 studies, a meta-analysis of 9 studies revealed a significantly lower alpha diversity (Shannon index) in CPs than in HCs (standardized mean difference (SMD): -0.53, 95% confidence intervals (95% CI): -0.97 to -0.09). Subgroup meta-analysis revealed a significantly lower alpha diversity (Shannon index) in older than younger individuals (SMD: -0.54, 95% CI: -0.86 to -0.23/SMD: -0.52, 95% CI: -1.18 to 0.14). At the genus level, the most significant changes were in Streptococcus and Neisseria, which had abundances that were significantly higher and lower in CPs than in HCs based on data obtained from six out of eleven and five out of eleven studies, respectively. DPP4 mRNA expression in the oral salivary gland was significantly lower in elderly individuals than in young individuals. Spearman correlation analysis showed that DPP4 expression was negatively correlated with the expression of viral genes. Gene enrichment analysis showed that DPP4-associated proteins were mainly enriched in biological processes, such as regulation of receptor-mediated endocytosis of viruses by host cells and bacterial invasion of epithelial cells.ConclusionThe oral microbial composition in COVID-19 patients was significantly different from that in healthy individuals, especially among elderly individuals. DPP4 may be related to viral infection and dysbiosis of the oral microbiome in elderly individuals.
Myocardial capacity of mitochondrial oxidative phosphorylation in response to prolonged electromagnetic stress
Authors: Savchenko Lesia , Martinelli Ilenia , Marsal Dimitri , Zhdan Vyacheslav , Tao Junwu , Kunduzova Oksana 
Published: June 2023

IntroductionMitochondria are central energy generators for the heart, producing adenosine triphosphate (ATP) through the oxidative phosphorylation (OXPHOS) system. However, mitochondria also guide critical cell decisions and responses to the environmental stressors.MethodsThis study evaluated whether prolonged electromagnetic stress affects the mitochondrial OXPHOS system and structural modifications of the myocardium. To induce prolonged electromagnetic stress, mice were exposed to 915 MHz electromagnetic fields (EMFs) for 28 days.ResultsAnalysis of mitochondrial OXPHOS capacity in EMF-exposed mice pointed to a significant increase in cardiac protein expression of the Complex I, II, III and IV subunits, while expression level of α-subunit of ATP synthase (Complex V) was stable among groups. Furthermore, measurement of respiratory function in isolated cardiac mitochondria using the Seahorse XF24 analyzer demonstrated that prolonged electromagnetic stress modifies the mitochondrial respiratory capacity. However, the plasma level of malondialdehyde, an indicator of oxidative stress, and myocardial expression of mitochondria-resident antioxidant enzyme superoxide dismutase 2 remained unchanged in EMF-exposed mice as compared to controls. At the structural and functional state of left ventricles, no abnormalities were identified in the heart of mice subjected to electromagnetic stress.DiscussionTaken together, these data suggest that prolonged exposure to EMFs could affect mitochondrial oxidative metabolism through modulating cardiac OXPHOS system.
Experimental evidence for the hydrothermal formation of native sulfur by synproportionation
Authors: Kürzinger Victoria , Hansen Christian T. , Strauss Harald , Wu Shijun , Bach Wolfgang 
Published: June 2023

Elemental sulfur (S0) is known to form in submarine acid-sulfate vents by disproportionation of magmatic SO2. S0 formed upon disproportionation shows δ34SS values considerably lower than the influxing magmatic SO2, which results in δ34SS values typically &lt;0‰. The peculiar occurrence of isotopically heavy sulfur in the Kemp Caldera hydrothermal system (δ34SS &gt; 5‰) and Niua North (δ34SS = 3.1‰) led to the suggestion that disproportionation is not the only sulfur forming process in submarine hydrothermal systems. We conducted hydrothermal experiments to investigate if synproportionation of SO2 and H2S can explain the occurrence and isotopic composition of S0 observed in some vent fields. Provided that SO2 and H2S are both abundant, this formation mechanism is thermodynamically conceivable, but it has not yet been demonstrated experimentally that this process actually takes place in submarine hydrothermal systems. We conducted the experiments in collapsible Ti-cells under pT-conditions (20–30 MPa, 220°C) that are relevant to S0 formation in submarine hydrothermal systems. We used starting concentrations of 10 mM sulfite and 20 mM sulfide of known isotopic composition. Under acidic conditions (pH25 °C = 1.2), S0 was the most abundant reaction product, but small amounts of sulfate were also produced. A Rayleigh fractionation model was applied to determine the isotopic composition of SO42–, SO2, H2S and S0 expected to form by SO2 disproportionation, H2S oxidation, and SO2–H2S synproportionation. The sulfur isotopic signatures of the sulfur produced in the experiments can only be explained by synproportionation of sulfite and sulfide. These results provide strong evidence that synproportionation is likely responsible for exceptionally high δ34SS values observed in S0 from some arc/back-arc hydrothermal environments, like the Kemp Caldera in the South Sandwich arc. Coeval degassing of H2S and SO2 is likely required to have this particular reaction dominate in the H–S–O reaction network and produce noticeable accumulations of isotopically heavy native sulfur at the seafloor.