bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community-Based 4-Level Intervention Targeting Depression and Suicidal Behavior in Europe: Protocol for an Implementation Project
Authors: Schnitzspahn Katharina , Abdulla Kahar , Arensman Ella , Van Audenhove Chantal , Mere Rainer , Pérez Sola Victor , Sisask Merike , Székely András , Toczyski Piotr , Hegerl Ulrich 
Published: January 2025

Background
The community-based, 4-level intervention of the European Alliance Against Depression (EAAD) is simultaneously addressing depression and suicidal behavior. Intervention activities target primary care health professionals (level 1), the general public (level 2), community facilitators (level 3), and patients and their relatives (level 4). Activities comprise the digital iFightDepression tool, a guided self-management tool based on cognitive behavioral therapy.

Objective
This study aimed to present the European Union–cofunded EAAD-Best study protocol, aiming at the implementation, dissemination, and evaluation of the 4-level intervention and the iFightDepression tool in several countries across Europe.

Methods
The 4-level intervention has been implemented for the first time in Bulgaria, Estonia, Greece, and Poland. In 3 countries that have already implemented the 4-level intervention (Hungary, Ireland, and Spain), activities have been extended to new regions. In addition, the nationwide uptake of the iFightDepression tool by patients with depression has been promoted in all mentioned countries and Italy.

Results
To evaluate the implementation of the 4-level intervention and the iFightDepression tool, data related to the process, output, and outcome were collected between 2022 and 2024. Data processing and analyses started in 2023. Analyses are expected to be completed in 2024. Results are expected to be published in 2025.

Conclusions
This paper informs researchers, practitioners, and stakeholders on how to implement best practices in mental health promotion and evaluate their effectiveness.

International Registered Report Identifier (IRRID)
DERR1-10.2196/64218
The Effect of Liquidity, Liquid Assets, and Non-Performing Loans on Financial Performance with Cost Efficiency As A Moderation Variable Banking Listed on The Indonesia Stock Exchange
Authors: Marjohan Masno 
Published: January 2025

Objectives: This investigation aimed to ascertain the influence of Liquidity, Capital Adequacy, and Non-Performing Loans on Financial Performance while considering the moderating role of Cost Efficiency. Methodology: This study utilizes secondary data collected through purposive sampling. 100 samples were selected based on specific criteria over 5 time periods using the EViews testing tool. The data was analyzed using Panel Data Regression with Moderating Regression Analysis. Finding: Liquidity and capital adequacy positively impact financial performance, while non-performing loans have no significant effect. Cost efficiency strengthens the positive effects of liquidity and capital adequacy but not of non-performing loans.Conclusion: Enhancing financial performance is crucial for any organization, and liquidity and capital adequacy play a vital role in achieving this goal. These factors have been proven to have a favorable impact on the overall financial health of a company. Conversely, non-performing loans appear to have a negligible impact on financial performance. However, cost efficiency can further strengthen the positive effects of liquidity and capital adequacy, but it does not have the same impact on non-performing loans. Hence, focusing on maintaining high levels of liquidity and capital adequacy, along with improving cost efficiency, can greatly contribute to enhancing financial performance.
The Dynamics of Turnover Intentions: Emotional Intelligence, Thriving at Work, and Career Adaptability in an Indonesian Banking Sector
Authors: Arti Miladani Binti , Kurniawati Desi Tri 
Published: January 2025

Objectives: The research focuses on the high turnover intention ratio in the East Java banking sector. The aim is to explore the role of emotional intelligence (EI) in reducing employee turnover by considering thriving at work (TW) and career adaptability (CA). This research highlights the importance of emotional intelligence and its positive effects through training programs to reduce Turnover Intentions (TOI).Methodology: This research used an explanatory quantitative method involving 105 frontline employees. The sample used a saturated sampling method. Data was collected through questionnaires distributed to all frontliners, with 103 questionnaires returned. The data were analyzed using the SEM-PLS method.Finding: The result found that EI does not directly influence frontline employees' desire for TOI. Nonetheless, employees with high levels of EI tend to thrive more at work, reducing their desire for TOI. The ability to develop and adapt in the work environment can be a more significant factor in reducing TOI.Conclusion: EI is important in reducing the TOI of Bank frontline employees. Employees with high EI can better develop and adapt to a stressful work environment, reducing TOI and increasing well-being and commitment to self-development.
Effectiveness of multitask cognitive training in cardiac surgery patients in the early postoperative period: description of clinical cases
Authors: Trubnikova O. A. , Tarasova I. V. , Syrova I. D. , Kukhareva I. N. , Sosnina A. S. , Kupriyanova D. S. 
Published: January 2025

Aim. Approbation of a course of cognitive rehabilitation using multitasking cognitive training in the early postoperative period of coronary artery bypass grafting (CABG).Materials and Methods. The study involved 10 cardiac surgery patients who underwent a course of multitasking cognitive training in the early postoperative period of CABG. All patients underwent neurological and advanced neuropsychological testing before the intervention and upon completion of cognitive rehabilitation. The results of cognitive rehabilitation of two study participants are described as clinical cases.Results. Most patients (7 out of 10) responded positively to the course. It was also possible to achieve a reduction in the frequency of postoperative cognitive dysfunction (POCD) to 40 %. The individual relative change (Δ) index showed that 5 patients (50 %) improved by 20 % or more, or did not change their executive and psychomotor functions, attention scores in 3 patients (30 %), short-term memory improvement − 7 patients (70 %). Successful completion of cognitive rehabilitation course (no POCD) was observed in a man, 60 years old, with initial lack of cognitive impairment with sufficient level of motivation to undergo training. Whereas for a 68-year-old patient with preoperative cognitive impairment and reduced motivation, the training course was unsuccessful.Conclusion. Seven out of 10 patients showed satisfactory results in individual transferability of the multitask training course, as well as transfer of the training effect to other cognitive functions not trained. Two clinical cases demonstrated that the initial cognitive status, level of motivation and even gender of patients can affect the effectiveness of cognitive rehabilitation in the early postoperative period of coronary artery bypass grafting.
Characteristics of interpenetrating hydrogels based on fibrin and high molecular weight polyvinyl alcohol
Authors: Matveeva V. G. , Rezvova M. A. , Glushkova T. V. , Senokosova E. A. , Khanova M. Yu. , Krivkina E. O. , Torgunakova E. A. , Antonova L. V. 
Published: January 2025

Aim. In an in vitro experiment, to study the properties of the IPN hydrogel fibrin/high-molecular polyvinyl alcohol with an increased number of cryocycles and fibrinogen concentrations to assess the prospects for its use in the creation of small-diameter vascular prostheses.Materials and Methods. One-component samples of fibrin hydrogels containing 40 and 50 mg/ ml fibrinogen, PVA polymer (146000-186000 Da) 30 and 40 mg/ml and the corresponding groups of IPN hydrogel samples were polymerized: fibrin 40 mg/ml and PVA 30 mg/ml (F40P30), fibrin 40 mg/ ml and PVA 40 mg/ml (F40P40), fibrin 50 mg/ml and PVA 30 mg/ml (F50P30), fibrin 50 mg/ml and PVA 40 mg/ml (F50P40). PVA was cryostructured for 5 cycles.The structural properties of the samples were studied using SEM, histological staining of sections with hematoxylin and eosin, and IR spectroscopy. Biological properties were assessed by the viability, number and metabolic activity of cells colonized on the materials. The physical and mechanical properties of the samples were characterized by tensile strength, relative elongation and Young's modulus. The hemocompatibility of materials was assessed by contact activation of platelets and the percentage of erythrocyte hemolysis.Results. Sequential polymerization of fibrin and high-molecular-weight PVA produced an IPN hydrogel with a uniform distribution of components in the thickness and lower surface, but a predominant presence of PVA on the upper surface. The structural heterogeneity of the material affected the biological properties. The lower surface of IPN hydrogels showed higher biocompatibility compared to the upper surface.The strength of IPN hydrogels increased with increasing PVA molecular weight, concentration and number of cryocycles, but did not reach a. mammaria. Hydrogels do not hemolyze red blood cells and do not activate platelets.Conclusion. Using a technique of sequential polymerization of fibrin and high molecular weight PVA over five cryocycles, a double-sided IPN hydrogel with high biocompatibility on the lower side and improved strength was obtained. However, the physical and mechanical characteristics of IPN hydrogel were weaker than a. mammaria, which requires new solutions.
Expression of ER, PR and Ki-67 in tumor with different genetic variants of ESR and levels of antiidiotypic antibodies to steroid hormones in breast cancer patients
Authors: Glushkov A. N. , Polenok E. G. , Gordeeva L. A. , Mun S. A. , Glushkova O. A. , Zakharov V. N. , Antonov A. V. , Bayramov P. V. , Verzhbitskaya N. E. , Voronina E. N. , Kolpinskiy G. I. 
Published: January 2025

Aim. To study the possible associations of tumor ER, PR and Ki-67 expression with ESR1 and ESR2 genes polymorphisms and blood serum levels of antiidiotypic antibodies IgG2-E2 and IgG2-Pg in breast cancer patients (BCP).Materials and Methods. Blood serum levels of IgG2-E2 and IgG2-Pg were studied in 1025 BCP (478 with stage I and 547 with stages II-IV) by means of enzyme-linked immunosorbent assay. Real-time PCR was performed for ESR1(rs2234693) and ESR2 (rs4986938) genes polymorphisms detection. ER, PR and Ki-67 positive tumor cells was determined using immunohistochemistry.Results. IgG2-E2 and IgG2-Pg blood serum levels were not depended on ESR1 and ESR2 gene polymorphisms in BCP. ER+/PR+ tumors were revealed more frequently and ER-/PR- tumors less frequently in BCP at the I stage with high serum levels of both IgG2-E2 and IgG2-Pg than in BCP with their low levels: in patients with genotype TC ESR1 (91.8 % and 3.3 % vs 73.9 % and 11.1%, p = 0.015). Such differences were not revealed in patients with genotypes TT and CC ESR1. There were not discovered the desired association of ER/ PR tumor phenotype with studied antibodies and ESR2 genes polymorphisms. High levels of tumors Ki-67 positive cells (>20%) were determined less frequently in BCP at the II-IV stages with high levels of both IgG2-E2 and IgG2-Pg than in BCP with their low levels: in patients with genotypes TC ESR1 (48.4 % vs 69.7 %, p = 0.004) and GA ESR2 (46.8 % vs 66.3 %, p = 0.009). There were not revealed such differences in patients with other variants of ESR1 and ESR2 genotypes.Conclusion. Synergistic effects of IgG2-E2 and IgG2-Pg were discovered in BCP: the maintenance of ER and PR in tumors at the I stage and inhibition of tumor proliferation at the II-IV stages.
Aktivitas Antidiabetes Ekstrak Gryllus Bimaculatus terhadap Penurunan Glukosa Darah Tikus Jantan (Rattus norvegicus) Diabetes
Authors: As'ari Hasyim , Nurmasari Fitri , Safitri Tika 
Published: January 2025

Penelitian ini bertujuan untuk mengidentifikasi efek ekstrak Gryllus bimaculatus terhadap kadar gula darah dan kolesterol pada tikus diabetes (Rattus norvegicus). Metode yang digunakan adalah eksperimen laboratorium dengan desain acak lengkap (Randomized Complete Design) yang melibatkan lima kelompok perlakuan: kontrol negatif (Na-CMC 0,5%), kontrol positif (Glibenklamid 0,013 mg/kgBB), serta tiga kelompok yang masing-masing menerima ekstrak Gryllus bimaculatus pada dosis 12,5 mg/kgBB (P1), 25 mg/kgBB (P2), dan 50 mg/kgBB (P3). Setelah perlakuan, kadar gula darah dan kolesterol diukur menggunakan alat Easy Touch GCU pada penelitian hari ke-17 dan ke-25. Analisis data menggunakan uji Anova dan uji Duncan dengan IMB SPSS statistics 25. Hasil penelitian menunjukkan bahwa pemberian ekstrak pada dosis 50 mg/kgBB (P3) dapat menurunkan kadar gula darah mendekati normal selma 14 hari dengan penurunan sebesar 39,11% (dari 354,40 ± 7,53 mg/dL menjadi 215,80 ± 5,21 mg/dL), sedangkan kadar kolesterol menurun hingga 17,64% (dari 230,20 ± 2,79 mg/dL menjadi 189,60 ± 4,76 mg/dL). Analisis statistik menggunakan uji ANOVA menunjukkan perlakuan berpengaruh terhadap penurunan kadar gula darah, dan uji Duncan menunjukkan seluruh kelompok perlauan ekstrak Gryllus bimaculatus berbedanyata, dengan P3 memiliki efektivitas serupa dengan kontrol positif Glibenklamid. Kesimpulan penelitian ini menunjukkan dosis ekstrak Gryllus bimaculatus 50 mg/kgBB (P3) efektif dalam menurunkan kadar gula darah dan berpotensi sebagi alternatif dalam mengatasi hiperkolesterolemia.
Evaluation and treatment of lead toxicosis in rehabilitated avian species: 95 cases (2014–2023)
Authors: Elliott Stephanie A. , Hawkins Shawna , Lemley Erin , McCormick Logan , Mans Christoph 
Published: January 2025

Abstract

OBJECTIVE
To evaluate avian patients presented to a wildlife rehabilitation facility with confirmed lead toxicity for clinical signs associated with blood lead level groups, efficacy of subcutaneous chelation therapy with calcium disodium EDTA, and case outcome based on presenting blood lead levels.

METHODS
A retrospective record review of 95 avian cases representing 19 species treated for lead toxicosis from a wildlife rehabilitation center in Wisconsin between 2014 and 2023 was conducted. Data were evaluated for presenting complaints, clinical signs, radiographic findings, chelation therapy protocol, clinical pathology data, and case outcome.

RESULTS
A low lead level of < 20 µg/dL was the most commonly diagnosed level in avian patients. The presence of neurologic disease was found most commonly in birds with higher blood lead levels, whereas poor body condition, trauma, and anemia were most common in birds with low lead levels. Bald eagles (Haliaeetus leucocephalus) and tundra swans (Cygnus columbianus) were the most prevalent species presented. All methods of chelation therapy evaluated resulted in a reduction of blood lead levels. Patients with intake blood lead levels > 60 µg/dL were more likely to die or be euthanized while in care.

CONCLUSIONS
A bird with a blood lead level > 60 µg/dL is more likely to present with neurologic disease and have a poor case outcome. Diluted calcium disodium EDTA was clinically effective when administered SC.

CLINICAL RELEVANCE
Initial blood lead level, in conjunction with species, clinical signs, and radiographic changes, can help guide clinical decision-making for avian patients with lead toxicosis.
Outcomes associated with local treatment of nasal planum squamous cell carcinoma in dogs: 89 cases (2003–2020)
Authors: Raleigh Joseph S. , Culp William T. N. , Giuffrida Michelle A. , Thomson Chris , Martin Tiffany , Mathews Kyle G. , Skinner Owen , Leonardi Abby , Bertran Judith , Selmic Laura E. , Dornbusch Josephine , Wilson Jordan , Oblak Michelle , Fransson Boel , Lux Cassie N. , Wustefeld-Janssens Brandan , Hollenbeck Danielle , Liptak Julius M. , Phillips Heidi , Selting Kim A. , Park Ji Eun , Wallace Mandy , Steffey Michele A. , Balsa Ingrid M. , Mayhew Philipp D. , Rebhun Robert B. , Kent Michael S. 
Published: January 2025

Abstract

OBJECTIVE
To describe the clinical characteristics, treatments, complications, and outcomes in dogs with nasal planum squamous cell carcinoma (SCC) undergoing local treatment.

METHODS
A retrospective, multi-institutional study was performed. Medical records were searched to identify dogs diagnosed with nasal planum SCC. Variables were recorded from medical records and statistically analyzed.

RESULTS
89 dogs were included. The most common presenting complaint was a visible mass on the nasal planum (89%). Metastasis was detected in 12% of dogs at the time of local therapy. Local therapy consisted of surgical excision alone in 63 of 89 dogs (71%) and radiation therapy alone in 20 of 89 dogs (22%); 6 dogs had multiple local therapies. Tumor size decreased in 12 dogs (60%) undergoing radiation therapy alone. Local recurrence was reported in 19 of 89 dogs (21%), including 16 of 63 dogs (25%) treated with surgery alone. Median survival time of all dogs was 452 days (95% CI, 285 to 576). Median survival time among 33 dogs with documented disease progression was 336 days (95% CI, 189 to 458), versus 685 days (95% CI, 334 to 1,042) in 56 dogs that did not have documented disease progression, which was significantly different (P = .038). Documented disease progression was significantly associated with hazard of death (hazard ratio, 1.93; 95% CI, 1.03 to 3.63; P = .041).

CONCLUSIONS
Dogs undergoing local treatment of nasal planum SCC had a favorable prognosis. Metastasis at the time of treatment was uncommon. Long-term survival was possible, particularly in cases without disease progression.

CLINICAL RELEVANCE
Aggressive local therapy, particularly surgical resection, should be considered in dogs with nasal planum SCC.
Postoperative prophylactic antibiotics were not associated with decreased surgical site infections following hemilaminectomy in dogs: a retrospective study
Authors: Jaramillo Ericka L. , Frederick Steven W. , Israel Sarah K. 
Published: January 2025

Abstract

OBJECTIVE
To compare hemilaminectomy surgical site infection (SSI) rates in dogs treated with or without postoperative prophylactic antibiotics.

METHODS
Medical records of 275 client-owned dogs from 1 tertiary referral hospital were retrospectively reviewed for dogs treated with thoracolumbar hemilaminectomy for intervertebral disk herniation between 2018 and 2023. Dogs were grouped according to whether they were treated with prophylactic postoperative antibiotics (group A) or not (group B). Relevant case details including dog signalment, duration of anesthetic procedure, method of incision closure, perioperative and prophylactic postoperative antibiotic prescription, and diagnosis of postoperative SSI (as defined by the CDC) were recorded. Wilson binomial CIs were calculated for SSI rates. Surgical site infection rates between dogs given or not given antibiotics were analyzed with a Fisher exact test.

RESULTS
The overall SSI rate was 3% (8 of 275; 95% CI, 1% to 6%). The SSI rate in group A was 3% (5 of 147; 95% CI, 1% to 8%), which was not statistically different from the 2% SSI rate (3 of 128; 95% CI, 1% to 7%) in group B (P = .728). There was not a statistical difference in SSI rates between closure methods (intradermal absorbable, 1% [1 of 79]; cutaneous staples, 4% [7 of 184]; cutaneous nylon, 0% [0 of 12]; P = .611).

CONCLUSIONS
Overall hemilaminectomy SSI rates in this study were low, and prescription of prophylactic antibiotics was not associated with a decreased SSI rate.

CLINICAL RELEVANCE
Practicing antimicrobial stewardship through avoidance of antimicrobial prophylaxis in clean surgical procedures may not be clinically detrimental to outcomes in hemilaminectomy dogs.
The Use of Technological Innovations in the Field From The Perspective of Rural Producers in Goiás
Authors: Pereira Ivone Vieira , Magalhaes Joice Carolina Sousa , Freitas Leninne Guimaraes , Furnieles Claudemir Bertuolo 
Published: January 2025

Objective: The objective of this study was to identify the technological innovations used in the field by rural producers in Goiás. Responsible for giving an impulse to agribusiness, Agro 4.0, also known as digital agriculture, goes beyond the simple mechanization of the countryside.

Theoretical picture: The operations and decisions take into variable considerations such as the climate, land and crop from which data collected by digital technologies is taken in real time. The use of technological innovations is transforming agribusiness in a surprising way, and is growing increasingly more among rural producers.

Method: The research has a qualitative nature, classified as exploratory, the collection of data was carried out through the application of a questionnaire. The data analysis was carried out in a descriptive manner.

Results and discussion: The results obtained made it possible to identify that 82.69% of the participating producers use some kind of technological innovation, and that 69.23% use some kind of on-board technology. Through the collected data it is possible to observe that the main technologies used by the participants in this study are GPS, drones and management software.

Implications of the research: The rural producers from Goiás make use of on-board technology.

Originality and value: The relevance of this research is to demonstrate what technological innovations the rural producers in Goiás are using in the field in order to emphasize its applicability by demonstrating the benefits and challenges in agro 4.0. This study seeks to offer significant contributions not only to academia, but also to professionals active in the market, fostering a deeper understanding of the advantages and usability of technological innovations in the field.
Peningkatan Kreativitas Bernilai Ekonomi Pada Komunitas Perempuan Hebat Sumenep Melalui Pelatihan Kerajinan Tangan Merajut
Authors: , Isyanto , Yuliastina Roos , Hidayat Imam 
Published: January 2025

Mitra PKM ini adalah Komunitas Perempuan Hebat Sumenep atau disingkat dengan istilah KPHS. Komunitas ini terbentuk pada tahun 2021, dan pada tanggal 04 April tahun 2022 telah resmi menjadi lembaga swadaya masyarakat legal berdasarkan akta notaris Naghfir, S.Hi, S.H, M.H. Jumlah Anggota KPHS sampai saat ini sebanyak 75 orang, dimana seluruh anggota yang bergabung dalam KPHS adalah perempuan dengan status janda. Peran sebagai single parent atau perempuan kepala keluarga memberi beban tersendiri bagi perempuan pasca perceraian. Posisi sebagai perempuan kepala keluarga menuntut perempuan – perempuan pacsa perceraian menanggung peran ganda, yaitu sebagai kepala keluarga dan sekaligus sebagai ibu rumah tangga. Hal ini terjadi karena baik perempuan janda cerai atau ditinggal mati dituntut mampu mengkombinasikan secara baik antara pekerjaan domestik dan publik, seperti harus mencari uang untuk menafkahi keluarganya dan juga harus memenuhi kebutuhan kasih sayang keluarganya (anak-anaknya). Fenomen ini yang menjadi dasar kegiatan PKM ini dilakukan, tujuan dari kegiatan PKM ini adalah memberikan peluang bagi komunitas perempuan (status janda) untuk dapat meningkatkan kreativitas sehingga membuka peluang usaha rumah tangga untuk meningkatkan pendapatan melalui pelatihan kerajinan tangan merajut. Luaran kegiatan ini dibagi menjadi tiga aspek, (1) luaran secara akademik berupa publikasi jurnal PKM ber ESSN, (2) poster kegiatan PKM dan video kegiatan PKM, dan yang terakhir tercapainya target keterampilan mitra PKM melalui kegiatan merajut