bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eskalasi Perkebunan Kelapa Sawit terhadap Masyarakat Suku Pedalaman di Suku Sakai Riau
Authors: Wahyuni Putri 
Published: June 2023

Perkebunan kelapa sawit merupakan industri strategis Indonesia. Sejak 2000, industri minyak sawit Indonesia berkembang pesat dan memengaruhi dinamika persaingan antar minyak nabati termasuk bentuk kampanye hitam dan tuduhan sebagai pemicu deforestasi di Indonesia. Industry perkebunan kelapa sawit mempunyai peran besar dalam perkembangan ekonomi Indonesia. Perindustrian ini menyumbang devisa terbesar ke dalam kas Negara. Selain penghasil devisa, Kelapa sawit juga menyumbang penyerapan tenaga kerja. Tujuan penelitian ini adalah menganalisis (1) apakah perkebunan kelapa sawit merupakan pemicu utama deforestasi di Indonesia; dan (2) bagaimanakah kontribusi industri minyak sawit Indonesia terhadap pembangunan berkelanjutan, baik secara ekonomi, sosial, maupun ekologi. Jenis Penelitian ini termasuk Penelitian Deskriptif Kualitatif. Sumber data yang digunakan berupa dokumen-dokumen tentang deforestasi, data perkebunan kelapa sawit daerah Kalimantan serta, narasumber-narasumber yang berhubungan dengan masalah deforestasi. Dari hasil observasi, wawancara, serta dokumentasi, peneliti mengolah hasil tersebut secara deskriptif. Waktu penelitian dilakukan pada tanggal 9 Februari 2021 dengan lokasi Perkebunan sawit di Kalimantan. Hasil dari data tersebut sebagai berikut Pada 1950–2013, konversi hutan menjadi nonhutan cukup tinggi, yakni 98,8 juta hektare. Namun, luas perkebunan kelapa sawit Indonesia hanya meningkat dari 0,1 juta ha (1950) menjadi 10,4 juta ha (2013). konversi lahan pertanian, dan hanya 3,4% yang dikonversi dari hutan primer. Hal ini membuktikan anggapan bahwa perkebunan kelapa sawit sebagai pemicu utama deforestasi di Indonesia tidak benar. Kesimpulannya isu deforestasi buka menjadi pemicu hilangnya kawasan perhutanan di Indonesia. Akan tetapi, disebabkan oleh masalah lain yakni kebakaran hutan, illegal loging secara liar dan pengalian fungsi hutan menjadi kawasan perumahan atau industry pabrik.
Penggunaan Metode Pembelajaran Supervisi Klinis dalam Upaya Peningkatan Kemampuan Guru di SDN 4 Sikabu
Authors: Jusneti Jusneti 
Published: June 2023

Banyak kendala yang dihadapi SDN 4 Sikabu seperti sulitnya memperoleh tenaga pengajar sesuai bidangnya, terbatasnya guru tetap, kurangnya pengalaman mengajar bagi guru pada SD tersebut. Peningkatan kualitas yang mendesak dilakukan adalah kemampuan Guru dalam menggunakan metode pembelajaran agar pembelajaran lebih terarah sehingga diharapkan mampu meningkatkan persentase ketuntasan belajar siswa. Salah satu upaya yang dilakukan adalah melakukan kegiatan visiting dalam melaksanakan proses belajar mengajar di dalam kelas. Tujuan penelitian ini adalah untuk meningkatkan kemampuan Guru SDN 4 Sikabu dalam menggunakan metode pembelajaran dan menentukan langkah yang tepat untuk meningkatkan kemampuan guru dalam menggunakan metode pembelajaran melaui spervisi klinis. Penelitian dilakukan di SDN 4 Sikabu selama kurang lebih tiga bulan di mulai tanggal 22 Juli sampai tanggal 4 September 2018. Pengumpulan data dilakukan melalui angket, observasi dan dokumentasi. Penelitian dilakukan sebanyak 2 siklus. Perolehan hasil pada siklus I sebesar 58,23% guru berhasil menggunakan metode pembelajaran dan pada siklus 2 terdapat 91,66% guru berhasil menyelesaikan menggunakan metode pembelajaran. Terdapat peningkatan kemampuan guru dalam menggunakan metode pembelajaran setelah dilakukan supervisi klinis tahap 1 yaitu sebesar 33,43% dan masing-masing guru menunjukkan peningkatan yang signifikan. Supervisi klinis adalah salah satu pola yang sangat efektif untuk meningkatkan kemampuan guru dalam menggunakan metode pembelajaran.
PENGARUH KEBIASAAN BELAJAR DAN FASILITAS BELAJAR TERHADAP HASIL BELAJAR SISWA KELAS XI PADA MATA PELAJARAN EKONOMI SMK SWASTA HKBP PEMATANG SIANTAR T.A 2021/2022
Authors: Sihombing Sotarduga , R I Turnip Melki , Simatupang Leo 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui Pengaruh Kebiasaan Belajar Dan Fasilitas Belajar Siswa Kelas XI Pada Mata Pelajaran Ekonomi Di SMK Swasta HKBP Pematang Siantar T.A 2021/2022. Penelitian berjenis kuantitatif. Teknik pengambilan sampel dalam penelitian ini adalah teknik random sampling dengan jumlah sampel 60 siswa kelas XI SMK Swasta HKBP Pematang Siantar T.A 2021/2022. Teknik pengumpulan data dengan menggunakan angket dan dokumentasi. Data yang diperoleh berupa data angket respon siswa terhadap kebiasaan belajar dan fasilitas belajar siswa untuk melihat hasil belajar siswa selama pembelajaran berlangsung. Instrumen yang digunakan adalah angket kebiasaan belajar an fasilitas belajar. Uji hipotesis yang digunakaan adalah uji t parsial. Hasil penelitian menunjukkan bahwa ada Pengaruh Kebiasaan Belajar Dan Fasilitas Belajar Siswa Kelas XI Pada Mata Pelajaran Ekonomi Di SMK Swasta HKBP Pematang Siantar T.A 2021/2022 , hal ini ditunjukkan dari hasil Uji t yang telah peneliti lakukan yakni nilai thitung X1(2,1377), lebih besar daripada ttabel pada taraf signifikansi 5% (2.0009), menunjukkan H1 diterima dan H0 ditolak. Dan hasil uji t X2 ,yakni thitung (2,32425) dan (2.0009)
PEROGRAM PENINGKATAN SEMANGAT BELAJAR KEPADA ANAK-ANAK MDA DI KAMPUNG TEGAL HEAS PURWAKARTA
Authors: Aulia Gina , Setiawan Usep 
Published: June 2023

Penelitian ini bertujuan untuk program peningkatan semangat belajar terhadap anak-anak MDA di Kampung Tegal Heas Purwakarta, sebelumnya di kampung tersebut tidak ada pendidikan MDA yang dilaksanakan siang hari, mereka mengaji hanya di malam hari. Dengan itu saya dan rekan-rekan KPM mendirikan pengajian MDA yang dilaksanakan di siang hari pada jam 14.00 sampai waktu adzan asar tiba. Dengan adanya MDA anak-anak di Tegal Heas, mereka sangat antusias dalam mengikuti pembelajaran di MDA. Di Tegal Heas tersebut masyarakanya sangat minim, bahkan anak-anak yang ada di Tegal Heas kurang lebih hanya 15 orang anak, anak-anak tersebut dari kelas 1, 2, 3, 5, dan 6. Sedikitnya anak-anak di Tegal Heas mereka tidak pernah menyerah dalam belajar ilmu agama maupun ilmu umum, mereka sekolah harus turun dari gunung ke perkampungan tetangga, bahkan akses jalan yang sangat jauh dan anak-anak berangkat jalan kaki tidak boleh ada yang menggunakan sepedah motor karena itu sudah peraturan dari sekolahnya agar tidak ada rasa cemburu sosial. Madrasah Diniyah Takmiliyah (MDA) merupakan lembaga pendidikan Islam yang sudahdikenal sejak awal perkembangan Islam di Nusantara. Pengajaran Islam saat itu berkembang alamiah melalui proses alkuturasi yang berjalan secara perlahan dan damai dan akhirnya menjadi bagian tak terpisahkan dari kehidupan masyarakat.
Concordance of microbial and visual health indicators of white-band disease in nursery reared Caribbean coral Acropora cervicornis
Authors: Schul Monica D. , Anastasious Dagny-Elise , Spiers Lindsay J. , Meyer Julie L. , Frazer Thomas K. , Brown Anya L. 
Published: June 2023

Background
Coral diseases are one of the leading causes of declines in coral populations. In the Caribbean, white band disease (WBD) has led to a substantial loss of Acropora corals. Although the etiologies of this disease have not been well described, characterizing the coral microbiome during the transition from a healthy to diseased state is critical for understanding disease progression. Coral nurseries provide unique opportunities to further understand the microbial changes associated with diseased and healthy corals, because corals are monitored over time. We characterized the microbiomes before and during an outbreak of WBD in Acropora cervicornis reared in an ocean nursery in Little Cayman, CI. We asked (1) do healthy corals show the same microbiome over time (before and during a disease outbreak) and (2) are there disease signatures on both lesioned and apparently healthy tissues on diseased coral colonies?

Methods
Microbial mucus-tissue slurries were collected from healthy coral colonies in 2017 (before the disease) and 2019 (during the disease onset). Diseased colonies were sampled at two separate locations on an individual coral colony: at the interface of Disease and ∼10 cm away on Apparently Healthy coral tissue. We sequenced the V4 region of the 16S rRNA gene to characterize bacterial and archaeal community composition in nursery-reared A. cervicornis. We assessed alpha diversity, beta diversity, and compositional differences to determine differences in microbial assemblages across health states (2019) and healthy corals between years (2017 and 2019).

Results
Microbial communities from healthy A. cervicornis from 2017 (before disease) and 2019 (after disease) did not differ significantly. Additionally, microbial communities from Apparently Healthy samples on an otherwise diseased coral colony were more similar to Healthy colonies than to the diseased portion on the same colony for both alpha diversity and community composition. Microbial communities from Diseased tissues had significantly higher alpha diversity than both Healthy and Apparently Healthy tissues but showed no significant difference in beta-diversity dispersion. Our results show that at the population scale, Healthy and Apparently Healthy coral tissues are distinct from microbial communities associated with Diseased tissues. Furthermore, our results suggest stability in Little Cayman nursery coral microbiomes over time. We show healthy Caymanian nursery corals had a stable microbiome over a two-year period, an important benchmark for evaluating coral health via their microbiome.
Genetic polymorphism of the Dab2 gene and its association with Type 2 Diabetes Mellitus in the Chinese Uyghur population
Authors: Li Yan-Peng , Adi Dilare , Wang Ying-Hong , Wang Yong-Tao , Li Xiao-Lei , Fu Zhen-Yan , Liu Fen , Aizezi Aibibanmu , Abuzhalihan Jialin , Gai Min-Tao , Ma Xiang , Li Xiao-mei , Xie Xiang , Ma Yi-Tong 
Published: June 2023

Objective
The human Disabled-2 (Dab2) protein is an endocytic adaptor protein, which plays an essential role in endocytosis of transmembrane cargo, including low-density lipoprotein cholesterol (LDL-C). As a candidate gene for dyslipidemia, Dab2 is also involved in the development of type 2 diabetes mellitus(T2DM). The aim of this study was to investigate the effects of genetic variants of the Dab2 gene on the related risk of T2DM in the Uygur and Han populations of Xinjiang, China.

Methods
A total of 2,157 age- and sex-matched individuals (528 T2DM patients and 1,629 controls) were included in this case-control study. Four high frequency SNPs (rs1050903, rs2255280, rs2855512 and rs11959928) of the Dab2 gene were genotyped using an improved multiplex ligation detection reaction (iMLDR) genotyping assay, and the forecast value of the SNP for T2DM was assessed by statistical analysis of clinical data profiles and gene frequencies.

Results
We found that in the Uygur population studied, for both rs2255280 and rs2855512, there were significant differences in the distribution of genotypes (AA/CA/CC), and the recessive model (CC vs. CA + AA) between T2DM patients and the controls (P < 0.05). After adjusting for confounders, the recessive model (CC vs. CA + AA) of both rs2255280 and rs2855512 remained significantly associated with T2DM in this population (rs2255280: OR = 5.303, 95% CI [1.236 to −22.755], P = 0.025; rs2855512: OR = 4.892, 95% CI [1.136 to −21.013], P = 0.033). The genotypes (AA/CA/CC) and recessive models (CC vs. CA + AA) of rs2855512 and rs2255280 were also associated with the plasma glucose and HbA1c levels (all P < 0.05) in this population. There were no significant differences in genotypes, all genetic models, or allele frequencies between the T2DM and control group in the Han population group (all P > 0.05).

Conclusions
The present study suggests that the variation of the Dab2 gene loci rs2255280 and rs2855512 is related to the incidence of T2DM in the Uygur population, but not in the Han population. In this study, these variations in Dab2 were an independent predictor for T2DM in the Uygur population of Xinjiang, China.
Direct, indirect, and vicarious nature experiences collectively predict preadolescents’ self-reported nature connectedness and conservation behaviors
Authors: Yue Zhihui , Chen Jin 
Published: June 2023

Background
The quantity and context of children’s nature experiences are undergoing significant changes, exacerbating a pervasive negative cycle that could impact future conservation efforts. Therefore, it is essential to conduct further studies on the potential impacts of these changes on children’s willingness to engage in conservation practices.

Methods
We surveyed 2,175 preadolescents (aged 9–12) from rural and city schools in Hangzhou, Kunming, and Xishuangbanna, China, regarding their nature experiences (direct, indirect, and vicarious) and self-reported nature connectedness and conservation behaviors.

Results
We found that children in urban areas have higher frequencies of indirect and vicarious experiences than those in rural areas, with some direct nature experiences seldom reported among city respondents. Direct, indirect, and vicarious nature experiences significantly predicted children’s conservation behavior and collectively provided the highest predictive power for conservation behavior. Direct and vicarious experiences were strongly correlated with pro-nature behavior, and the latter with pro-environmental behavior. Emotional and cognitive connection with nature positively predicted conservation behavior, influenced by location and residence type.

Discussion
This study reveals that different types of nature experiences shape children’s current conservation behaviors in China.
Identification of iron metabolism-related genes as prognostic indicators for papillary thyroid carcinoma: a retrospective study
Authors: Jin Tiefeng , Ge Luqi , Chen Jianqiang , Wang Wei , Zhang Lizhuo , Ge Minghua 
Published: June 2023

Background
The thyroid cancer subtype that occurs more frequently is papillary thyroid carcinoma (PTC). Despite a good surgical outcome, treatment with traditional antitumor therapy does not offer ideal results for patients with radioiodine resistance, recurrence, and metastasis. The evidence for the connection between iron metabolism imbalance and cancer development and oncogenesis is growing. Nevertheless, the iron metabolism impact on PTC prognosis is still indefinite.

Methods
Herein, we acquired the medical data and gene expression of individuals with PTC from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) database. Typically, three predictive iron metabolism-related genes (IMRGs) were examined and employed to build a risk score (RS) model via the least absolute shrinkage and selection operator (LASSO) regression, univariate Cox, and differential gene expression analyses. Then we analyzed somatic mutation and immune cell infiltration among RS groups. We also validated the prognostic value of two IMRGs (SFXN3 and TFR2) by verifying their biological function through in vitro experiments.

Results
Based on RS, all patients with PTC were stratified into low- and high-risk groups, where Kaplan-Meier analysis indicated that disease-free survival (DFS) in the high-risk group was much lower than in the low-risk group (P < 0.0001). According to ROC analysis, the RS model successfully predicted the 1-, 3-, and 5-year DFS of individuals with PTC. Additionally, in the TCGA cohort, a nomogram model with RS was developed and exhibited a strong capability to anticipate PTC patients’ DFS. In the high-risk group, the enriched pathological processes and signaling mechanisms were detected utilizing the gene set enrichment analysis (GSEA). Moreover, the high-risk group had a significantly higher level of BRAF mutation frequency, tumor mutation burden, and immune cell infiltration than the low-risk group. In vitro experiments found that silencing SFXN3 or TFR2 significantly reduced cell viability.

Conclusion
Collectively, our predictive model depended on IMRGs in PTC, which could be potentially utilized to predict the PTC patients’ prognosis, schedule follow-up plans, and provide potential targets against PTC.
Analyzing the School Principal’s Role in Teacher Professional Development
Authors: Choeda Ugyen 
Published: June 2023

This article determined and analyzed the school principal’s roles in teacher professional development. This short research study was conducted to investigate the way in which principal’s coach and mentor teachers’ professional learning at the school level of primary schools in Bhutan.
Using the narrative-survey method, the finding reveals that, in general, a teacher should provide constant and timely coaching and monitoring, grant autonomy to make decisions, need to meet local needs and promote teamwork. Moreover, the principal should play a major role in involving teachers in leading, planning, encouraging, implementing, and evaluating.
“Branca é lésbica e preta é sapatona oh o erro?!":
Authors: Sousa Elaine Borges , Figueiredo Angela 
Published: June 2023

Este artigo é resultado de uma pesquisa monografia em Ciências Sociais, onde o tema identidade surgiu, a partir da fala de uma das interlocutoras, como um dos debates centrais para compreendermos as vivências de lésbicas e sapatonas negras periféricas. Desse modo, o presente trabalho se dedica em analisar a construção de identidades e autoafirmação de mulheres negras sapatonas e lésbicas, a partir de suas experiências no bairro de Pernambués, localizado na cidade de Salvador - Bahia. Através de uma abordagem qualitativa, a pesquisa buscou compreender como a intersecção dos vários marcadores sociais, como o gênero, raça, classe, sexualidade e território, criam lugares sociais, classificações, hierarquias e vulnerabilidades específicas para mulheres negras lésbicas e/ou sapatonas. Nesse processo foi possível identificar narrativas relacionadas a experiência de violências interseccionais, mas também sobre processos de construção de uma identidade referida ao resgate da autoestima e a ressignificação.
Hyperactivation of the JAK2/STAT5 Signaling Pathway and Evaluation of Baricitinib Treatment Among Patients With Eosinophilic Cellulitis
Authors: Morot Johanna , Del Duca Ester , Chastagner Marine , Fernandes Marie , Estrada Yeriel , Lefevre Marine-Alexia , Kanitakis Jean , Harou Olivier , Jullien Denis , Nicolas Jean-Francois , Krueger James G. , Vocanson Marc , Guttman-Yassky Emma , Villani Axel P. 
Published: June 2023

ImportanceThe pathogenesis of eosinophilic cellulitis (EC) is poorly understood, limiting available treatment options. The current treatment paradigm focuses on delayed type 2 hypersensitivity reaction to various triggers.ObjectiveTo gain further insight into the nature of EC inflammation and into the cellular signal transduction pathways that are activated in the context of EC.Design, Setting, and ParticipantsThis case series was conducted in Lyon, France, from January 2018 to December 2021. Analysis of archival skin biopsy samples from patients with EC and from healthy control participants was performed using histology, Janus kinase (JAK)–signal transducer and activator of transcription (STAT) immunohistochemistry, and gene profiling. Data analysis was conducted between January 2020 and January 2022.Main Outcomes and MeasuresPruritus (visual analog score), percentage of body surface area with lesional skin, and RNA transcripts of inflammatory biomarkers from the skin (threshold cycle) were assessed in 1 index patient with refractory EC who received oral JAK1/JAK2 inhibitor baricitinib (4 mg/d).ResultsThis study included samples from 14 patients with EC (7 men and 7 women) and 8 healthy control participants (4 men and 4 women). The mean (SD) age of patients was 52 (20) years. Marked type 2 inflammation (chemokines CCL17, CCL18, and CCL26 and interleukin 13) with preferential activation of the JAK1/JAK2–STAT5 pathways in EC lesions was observed. In the 1 index patient with refractory EC, complete clinical remission of skin lesions was observed after 1 month of treatment with baricitinib.Conclusions and RelevanceThese findings suggest that EC is a type 2 inflammatory disease with preferential activation of the JAK1/JAK2-STAT5 pathways. In addition, these results suggest the potential of treatment approaches targeting JAK1/JAK2 for patients with EC.
Transfascial Fixation vs No Fixation for Open Retromuscular Ventral Hernia Repairs
Authors: Ellis Ryan C. , Petro Clayton C. , Krpata David M. , Beffa Lucas R. A. , Miller Benjamin T. , Montelione Katie C. , Maskal Sara M. , Tu Chao , Huang Li-Ching , Lau Braden , Fafaj Aldo , Rosenblatt Steven , Rosen Michael J. , Prabhu Ajita S. 
Published: June 2023

ImportanceTransfascial (TF) mesh fixation in open retromuscular ventral hernia repair (RVHR) has been advocated to reduce hernia recurrence. However, TF sutures may cause increased pain, and, to date, the purported advantages have never been objectively measured.ObjectiveTo determine whether abandonment of TF mesh fixation would result in a noninferior hernia recurrence rate at 1 year compared with TF mesh fixation in open RVHR.Design, Setting, and ParticipantsIn this prospective, registry-based, double-blinded, noninferiority, parallel-group, randomized clinical trial, a total of 325 patients with a ventral hernia defect width of 20 cm or less with fascial closure were enrolled at a single center from November 29, 2019, to September 24, 2021. Follow-up was completed December 18, 2022.InterventionsEligible patients were randomized to mesh fixation with percutaneous TF sutures or no mesh fixation with sham incisions.Main Outcome and MeasuresThe primary outcome was to determine whether no TF suture fixation was noninferior to TF suture fixation for open RVHR with regard to recurrence at 1 year. A 10% noninferior margin was set. The secondary outcomes were postoperative pain and quality of life.ResultsA total of 325 adults (185 women [56.9%]; median age, 59 [IQR, 50-67] years) with similar baseline characteristics were randomized; 269 patients (82.8%) were followed up at 1 year. Median hernia width was similar in the TF fixation and no fixation groups (15.0 [IQR, 12.0-17.0] cm for both). Hernia recurrence rates at 1 year were similar between the groups (TF fixation, 12 of 162 [7.4%]; no fixation, 15 of 163 [9.2%]; P = .70). Recurrence-adjusted risk difference was found to be −0.02 (95% CI, −0.07 to 0.04). There were no differences in immediate postoperative pain or quality of life.Conclusions and RelevanceThe absence of TF suture fixation was noninferior to TF suture fixation for open RVHR with synthetic mesh. Transfascial fixation for open RVRH can be safely abandoned in this population.Trial RegistrationClinicalTrials.gov Identifier: NCT03938688