bluuebunny/crossref_metadata_2025_split huggingface dataset:
LEADERS: MAKE PEOPLE FEEL SPECIAL
Authors: Deierlein Tom 
Published: August 2023

AbstractThe author, a technology and nonprofit executive with a military background, knew Frances Hesselbein for a decade. When he first met her, in similarity to the circumstances of many other people, she had an immediate and profound effect: “I left feeling special and with an odd sense of empowerment that I could achieve whatever goals I had set.” He later became a professional mentor for “her mentoring and development program for teens, the Hesselbein Global Academy For Student Leadership and Civic Engagement Fifth Annual Leadership Summit at the University of Pittsburgh in July of 2013.” In drawing lessons from these experiences and encounters, the author writes: “We all meet dozens of people every day. We really have no idea what struggles and challenges they might be facing. If given the chance to talk or listen to them – take a few extra moments to help them feel special.”
THE WORLD ACCORDING TO FRANCES HESSELBEIN
Authors: Patouillet Leland D. 
Published: August 2023

AbstractThe author relates stories about his friendship with Frances Hesselbein, and how he was mentored by her. The major segment of the article is about the creation of the Frances Hesselbein Global Academy for Student Leadership and Civic Engagement at the University of Pittsburgh, where the author had a long career. He writes: “Frances continues to have a profound impact on my thinking today. One of her big ideas called for carrying a big basket. Frances explained it was important to adopt and adapt a given idea. This concept has become part of my DNA.” Frances’s leadership ideas are further explored, including the following, as related by the author: “Another big idea I learned from Frances was the need to establish a common language leading to a common vision resulting in common ground.”
Healthy Shrimps on the Platter: Encouraging Eco‐Friendly Means to Promote Shrimp Aquaculture Industry
Authors: Yadav Kanika , Verma Arunima Kumar , Pathak Ajey Kumar , Awasthi Abhishek 
Published: August 2023

AbstractShrimps contribute a considerable share to global food demands and are presumed to be one of the most popular delicacies worldwide. The nutrition value of shrimps is also very high. Shrimp aquaculture industry faces a lot of challenges due to anthropogenic or non‐anthropogenic reasons. Occurrence of disease is one of the chief reasons involved in management of shrimp aquaculture. The shrimps are highly fragile species and are markedly prone to various viral, bacterial, and fungal diseases. Past few decades of shrimp aquaculture have experienced deadly devastations due to viral and bacterial outbreaks. In order to prevent the recurrent disease, usage of the antibiotics has become customary practice as a therapeutic measure. The repercussion of using antibiotics in aquaculture is biomagnifications of toxic residues that further get accumulated in the food chains and food webs, eventually causing pollution in the environment. Hence, proper sanitation practices when synergistically used with immunostimulants, immunomodulators, pathogen free stocks, etc. can help the shrimp industry flourish in the current times. In the present paper, the importance of shrimps is described as food and eco‐friendly measures to preserve the global shrimp industry so that it can meet the escalating food demands globally.
Sustainable Urban Sanitation and Septage Management: A Study of Small Towns in Uttar Pradesh
Authors: Gupta A. K. , Joshi Mahendra 
Published: August 2023

AbstractWhen sanitation is first conceived, its scope is restricted to the removal of human waste using methods such as cesspools, open ditches, pit latrines, bucket systems, and the like. Today, it refers to a more comprehensive concept that encompasses the elimination of solid and liquid waste, the hygiene of food, as well as personal, domestic, and environmental cleanliness. Sanitation is one of the fundamental factors that determines both quality of life and the indicator of human growth. Infections can be avoided altogether by adhering to proper sanitation practices, which stop the contamination of water and soil. As a result, the concept of sanitation is broadened to encompass not only personal hygiene but also the cleanliness of the home, the provision of clean water, the removal of waste products (including feces and urine), and the disposal of waste water. The government of India has implemented the Swachchatam Sarvekshan programme and begun developing protocols like as ODF, ODF+, and ODF++ in order to guarantee the long‐term viability of inclusive sanitation infrastructure and the efficient application of these facilities. In light of this, the purpose of the current article is to investigate the state of urban sanitation and the management of septage in a few select small towns in the Indian state of Uttar Pradesh. The information used in the paper has been collected through filed survey.
Insight into Molecular Interaction between Viral Envelop Protein VP26 and Eco‐Friendly Phytochemical Quercetin
Authors: Kumar Santosh , Verma Arunima Kumar , Thakur Gaurav , Dwivedi Arti , Awasthi Abhishek 
Published: August 2023

AbstractWhite spot disease (WSD) is one of the most devastating diseases that has deteriorated shrimp production since past several decades. It is caused by white spot syndrome virus (WSSV) in almost all the species of shrimps across the globe. Understanding the complete disease mechanism and postulating a consolidated drug/antiviral is still under way. The major envelop proteins that assist the virus to penetrate into the shrimp are VP28, VP26, VP24, and VP19. VP26 a major constituent of the envelope plays a significant role in maintaining the structure of the envelope as well as helps the virus instigate the infection. The drugs and antiviral used to treat any viral infection conventionally efflux several toxic by‐products that degrade the structural properties of the environment. Since quercetin is a natural product obtained from plant sources, hence its degradation does not leave any toxic residues in the environment. This study has tried to understand the structural aspects of the viral envelop protein VP26. Additionally, the study has also tried to understand the interaction of a flavonoid quercetin with VP26. Computational approaches are used to explore the binding cavity of VP26 as well as trace the amino acid interactions shown by quercetin inside the binding cavity of VP26. The study reveals that quercetin shows good compatibility with VP26. Thus, using quercetin as an antiviral and mapping more detailed interaction of VP26‐quercetin can open pathway for development of antiviral against white spot disease.
Nursing students' perception of nursing knowledge: A qualitative study
Authors: Jensen Kari Toverud , Jerpseth Heidi 
Published: August 2023

AbstractAimTo explore nursing students' perception of nursing knowledge.DesignQualitative interview study.MethodsSemistructured individual interviews with nine nursing students in their third year were conducted via a cloud‐based video communication app. Transcriptions were analysed based on Braun and Clarke's thematic analysis. The Consolidated Criteria for Reporting Qualitative Research checklist for qualitative research was used.ResultsThe findings show that the participants emphasised that values are the prerequisites of and basis for performing professional nursing. The students found it difficult to define nursing knowledge and to distinguish nursing knowledge from other subjects. The thematic analysis resulted in two themes: values—a prerequisite of nursing knowledge, and nursing knowledge—an umbrella of knowledge.ConclusionNursing knowledge seems to be difficult both to clarify and to demarcate for the students. However, the participants considered values to be important and vital to becoming a professional nurse.Implications for the professionThis study addresses students' perceptions of values, nursing knowledge and what it consists of, and how this is experienced. An understanding of the nursing students' perceptions of what they consider to be important values and how they understand nursing knowledge is important in making the profession clearer and more distinguishable.ImpactThe impact of this study means that nurse education needs to emphasise a more argumentative and visible education where nursing knowledge and values are more prominent than today.Reporting MethodCOREQ.Public ContributionNo patient or public contribution.
Forward genetics and functional analysis highlight Itga11 as a modulator of murine psoriasiform dermatitis
Authors: Bieber Katja , Bezdek Siegfried , Gupta Yask , Vorobyev Artem , Sezin Tanya , Gross Natalie , Prüssmann Jasper , Sayegh Jean‐Paul , Becker Mareike , Mousavi Sadegh , Hdnah Ashref , Künzel Sven , Ibrahim Saleh M , Ludwig Ralf J , Gullberg Donald , Sadik Christian D 
Published: August 2023

AbstractPsoriasis is a chronic inflammatory skin condition. Repeated epicutaneous application of Aldara® (imiquimod) cream results in psoriasiform dermatitis in mice. The Aldara®‐induced psoriasiform dermatitis (AIPD) mouse model has been used to examine the pathogenesis of psoriasis. Here, we used a forward genetics approach in which we compared AIPD that developed in 13 different inbred mouse strains to identify genes and pathways that modulated disease severity. Among our primary results, we found that the severity of AIPD differed substantially between different strains of inbred mice and that these variations were associated with polymorphisms in Itga11. The Itga11 gene encodes the integrin α11 subunit that heterodimerizes with the integrin β1 subunit to form integrin α11β1. Less information is available about the function of ITGA11 in skin inflammation; however, a role in the regulation of cutaneous wound healing, specifically the development of dermal fibrosis, has been described. Experiments performed with Itga11 gene‐deleted (Itga11−/−) mice revealed that the integrin α11 subunit contributes substantially to the clinical phenotype as well as the histopathological and molecular findings associated with skin inflammation characteristic of AIPD. Although the skin transcriptomes of Itga11−/− and WT mice do not differ from one another under physiological conditions, distinct transcriptomes emerge in these strains in response to the induction of AIPD. Most of the differentially expressed genes contributed to extracellular matrix organization, immune system, and metabolism of lipids pathways. Consistent with these findings, we detected a reduced number of fibroblasts and inflammatory cells, including macrophages, T cells, and tissue‐resident memory T cells in skin samples from Itga11−/− mice in response to AIPD induction. Collectively, our results reveal that Itga11 plays a critical role in promoting skin inflammation in AIPD and thus might be targeted for the development of novel therapeutics for psoriasiform skin conditions. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Buds, clusters, and transitions in 21st century colorectal carcinoma: revolution or reinvention?†
Authors: Feakins Roger M , Loughrey Maurice B , Silver Andrew 
Published: August 2023

AbstractTumour budding (TB) describes single or small groups of neoplastic cells that lack continuity with an advancing tumour front. Poorly differentiated clusters (PDCs) are larger and qualitatively different. TB grade and PDCs may predict a worse outcome in colorectal carcinoma and other cancers and fall into the category of ‘invasive front prognostic markers’ that also includes intratumoural stroma type. Epithelial–mesenchymal transition (EMT) allows the adoption by epithelial cells of mesenchymal characteristics such as dyscohesion, migration, and stromal invasion. TB and PDCs harbor alterations in EMT‐related proteins and RNAs and may be morphological manifestations of EMT. However, persistence of epithelioid features and absence of a full complement of typical alterations in TB and PDCs may indicate ‘partial EMT’, i.e. an intermediate/hybrid state. Recently, Pavlič et al asserted that TB and PDCs in colorectal cancer represent different manifestations of partial EMT and, perhaps controversially, that TB is closer than PDCs to complete transition. In clinical practice, low inter‐observer agreement for invasive front prognostic markers is a potential problem. The UK colorectal cancer pathology dataset advises assessment of TB and recommends the use of an international consensus system, but time will tell if we are adopting reliable prognostic markers or reinventing the wheel. Additional studies of TB, PDCs, and EMT will presumably allow greater insight into their role in tumour development and progression. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Influence of particle granulometry and panel composition on the physico‐mechanical properties of ultra‐low‐density hemp hurd particleboard
Authors: Fehrmann Johannes , Belleville Benoit , Ozarska Barbara , Gutowski Wojciech (Voytek) S. , Wilson David 
Published: August 2023

AbstractThis study investigated Australian hemp hurd (Cannabis sativa L., “Frog One”) as a lignocellulosic raw material for ultra‐low‐density hemp particleboard (ULHPB) with densities ranging from 213 to 309 kg/m3. The hurd was first milled and fractionated into three particle size categories, that is, fine (F), medium (M), and coarse (C). Twelve unique ULHPB variants were then fabricated comprising varying particle loadings from four particle size mixes, that is, 100% C, 100% M, 50%/50% CM, 25%/50%/25% CMF, and adhesive contents of bio‐epoxy (EPX), phenol resorcinol formaldehyde (PRF), and emulsifiable methylene diphenyl diisocyanate (MDI), respectively. The panel assessments, conducted in accordance with the Australian reconstituted wood‐based panels standard AS/NZS 1859.1 (2017), revealed a significant effect of particle dimension on most physico‐mechanical properties. Furthermore, the resination method and pressing temperature controlled post‐cure panel expansion and additional panel characteristics. Notably, MDI‐ULHPB exhibited drastically different behavior and properties compared to EPX and PRF equivalents, demonstrating greater bending strength, stiffness, screw withdrawal strength, and dimensional stability. Importantly, all MDI variants conformed to the 15% thickness swelling limit for moisture resistant particleboard. Surface lamination of MDI‐bonded ULHPB with sheets of aluminum, Masonite, and Kraft liner significantly improved the inherently low flexural properties, suggesting the potential suitability of ULHPB as a core layer in lightweight sandwich composite panels. The integration of agricultural by‐products, such as hemp hurd, into engineered building materials presents a promising opportunity to mitigate the depletion of finite timber resources and aligns well with circular economy principles.Highlights
Utilizing agricultural residue as sustainable raw material in building products.
Hemp hurd enables ultra‐low‐density particleboard with thermosetting resins.
Coarse particle size mix enhances mechanical performance in panels.
Panel characteristics controlled by resination method and pressing temperature.
Lamination enhances functionality of lightweight hemp hurd sandwich panel.
An in vitro evaluation of the biocompatibility of proline‐alanine‐serine peptides compared with polyethylene glycol and polyglycerol
Authors: Zhang Qianyu , Chen Hongjing , Chen Huali 
Published: August 2023

AbstractPASylation has been recently reported as a feasible alternative to PEGylation, which in essence is using polypeptides constituted of a combination of proline, alanine and serine for the hydrophilic modification of pharmaceuticals. In this work, we focused on the biocompatibility evaluation of two PAS peptides, (PAS)8 and (PA3)7 as well as the more frequently used polymers polyethylene glycol (PEG) and polyglycerol (PG). It has been verified in this study that (PAS)8 and (PA3)7 both exhibited low cell toxicity against HUVEC and RAW 264.7 cell lines. They also showed negligible RBC hemolysis and agglutination, which demonstrated adequate hemocompatibility. Their potential interactions with bovine serum albumin have also been investigated, and the results indicated little hydrophobic interactions between the polymers and protein. In conclusion, (PAS)8 and (PA3)7 as well as PEG and PG all showed considerable compatibility and safety in these studies, suggesting that (PAS)8 and (PA3)7 could be considered as potential candidates for PEG replacement in future studies.
Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis
Authors: Freeze Robert , Yang Kelly W. , Haystead Timothy , Hughes Philip , Scarneo Scott 
Published: August 2023

AbstractRheumatoid arthritis (RA) is a complex autoimmune disease characterized by hyperactive immune cells within the joints, which leads to inflammation, bone degeneration, and chronic pain. For several decades, frontline immunomodulators such as the anti‐tumor necrosis factor (TNF) biologics adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade) have successfully managed disease progression for many patients. However, over time, patients become refractory to these treatments requiring chronic disease to be managed with conventional and more problematic disease modifying antirheumatic drugs such as methotrexate and hydroxychloroquine, and corticosteroids. Due to the large proportion of patients who continue to fail on frontline biologic therapies, there remains an unmet need to derive novel alternative targets with improved efficacy and safety profiles to treat RA. Recent advances in the field have defined novel targets that play important roles in RA pathology, including the Janus activated kinase (JAK) and transforming growth factor beta activated kinase‐1 (TAK1). Although three inhibitors of the JAK signaling pathway have been approved for the treatment of moderately to severely active RA in patients who failed on one or more anti‐TNFs, at present, no FDA approved TAK1 treatments exist. Our recent discovery of a highly potent and selective, orally bioavailable TAK1 inhibitor has provided insight into the therapeutic potential of this protein kinase as a novel target for RA. Here, we show the distinct cytokine signaling of tofacitnib (Xeljanz; JAK1/3 inhibitor) compared to HS‐276 (TAK1 inhibitor) in lipopolysaccharide (LPS) challenged THP‐1 cells. Furthermore, in the collagen induced arthritis pre‐clinical mouse model of RA, both tofacintib and HS‐276 attenuated disease activity score and inflammatory cytokines in the serum. Overall, our results delineate the distinct cytokine signaling of JAK1/3 and TAK1 targeted therapies in vitro and in vivo and suggest that selective TAK1 inhibitors may provide superior therapeutic relief in RA with fewer adverse events.
Monitoring autocorrelated multivariate multiple linear profiles
Authors: Wang Yi‐Hua Tina , Zhan Shu‐Han 
Published: August 2023

AbstractIf the quality of a process can be represented by a functional relationship, a collection of this quality data is called a profile. In monitoring schemes, profile monitoring is used to evaluate the stability of a relationship. In some applications, quality data collected from continuous processes have time correlations and can thus be characterized by a linear relationship between more than one response and explanatory variables. Therefore, we investigate this type of multivariate multiple linear regression model with between‐profile correlations in this study. We propose two exponentially weighted moving average control charts for monitoring the regression parameters and the covariance matrix of the model. Our simulation results reveal that our proposed scheme has satisfactory performance in terms of the average run length and standard deviation run length criteria. Finally, we present an example using real data to demonstrate the applicability of the proposed scheme.
The Linkage‐Moderated Covalent Organic Frameworks with C=N and NN on Charge Transfer Kinetics Towards the Robust Photocatalytic Hydrogen Activity
Authors: Wu Haiyang , He Xuan , Du Xing , Wang Daheng , Li Weixin , Chen Hui , Fang Wei , Zhao Lei 
Published: August 2023

AbstractSince the linkages structured in covalent organic frameworks (COFs) usually impact the charge transfer behavior during photocatalytic hydrogen evolution reaction (pc‐HER), linkage dependence on charge transfer kinetics should be further claimed. Herein, COFs with N‐based linkages and pyrene‐based building nodes are constructed to enable us to obtain new clues about the charge transfer behavior and evolution tendency relevant to linkages at a molecular level for pc‐HER. It is demonstrated that photo‐excited electrons preferably move to the N sites in C=N linkage for pc‐HER and are trapped around NN linkage as well. A high electron transfer rate does not point to high photocatalytic activity directly, while a small difference between the electron transfer rate and electron recombination rate ΔkCT − CR predicts the inefficiency of charge transfer in Azod‐COFs. Contrarily, large value of ΔkCT − CR in the case of Benzd‐COFs, demonstrats an unimpeded charge transfer process to result in boosted pc‐HER rate (2027.3 µmol h−1 g−1). This work offers a prominent strategy for the reasonable design of efficient photocatalysts at the molecular level for structural regulation and achieves an efficient charge transfer process for the pc‐HER process.
Report of the General Committee: 26
Authors: Wilson Karen L. 
Published: August 2023

SummaryDecisions of the General Committee are reported on about half of the proposals and requests in Report 73 of the Permanent Nomenclature Committee for Vascular Plants and Report 16 of the Permanent Nomenclature Committee for Fossils. As specified by the Code, the GC was consulted by the NC Fungi on several matters relating only to fungi.
Magnetic resonance imaging in polymyalgia rheumatica—contrast enhancement is not always needed
Authors: Fruth Martin , Seggewiss Annika , Kozik Jessica , Martin-Seidel Philipp , Baraliakos Xenofon , Braun Jürgen 
Published: August 2023

Abstract
Background
Extracapsular inflammation at entheseal sites in the pelvic girdle as demonstrated by magnetic resonance imaging (MRI) was shown to be useful as an additional tool for diagnosing polymyalgia rheumatica (PMR). However, it is unclear whether MRI needs to be performed with contrast enhancement or whether oedema-sensitive sequences are sufficient.

Objective
To evaluate the performance of T2w TIRM (turbo inversion recovery magnitude) imaging compared to fat-saturated contrast-enhanced (ce) T1w at predefined pelvic sites to detect extracapsular inflammation in patients with PMR.

Methods
A total of 120 pelvic MRIs of patients with pelvic girdle pain, 40 with clinically diagnosed PMR and 80 controls, were retrospectively scored by three blinded radiologists separately evaluating the MRI with and without contrast enhancement at 19 previously defined pelvic structures. The intra- and interrater reliability and the diagnostic performance of both techniques were statistically analysed and evaluated.

Results
The detection of inflammatory MRI signals correlated moderately between both techniques (Cohen’s κ 0.583). With ceT1w imaging 20.7% more sites were detected as inflamed compared to T2w TIRM in PMR patients. Inter- and intrareader reliability was superior with ceT1w imaging. If the inflammatory signal was detected at three sites bilaterally including the origin of the rectus femoris muscle or adductor longus muscle, the sensitivity and specificity was 100% and 97.1% by ceT1w imaging vs. 80.8% and 93.3% by T2w TIRM, respectively.

Conclusion
Contrast enhancement is superior to oedema-sensitive MRI in the detection of extracapsular inflammation in PMR. However, using T2w TIRM also detects many but not all PMR cases.