bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antipyretic Effect of Oral Dipyrone (Metamizole) Compared to Oral Ibuprofen in febrile Children: A Systematic Review and Meta-Analysis
Authors: Alnajar Maged , Saker Zahraa , Haji Fatma , Abdelsamed Menna , Khaled Zeinab , Abd-ElGawad Mohamed 
Published: June 2023

Abstract

Background
The nonsteroidal anti-inflammatory medication dipyrone (metamizole) is most frequently used as a painkiller as well as an anti - pyretic. Despite the fact that it has been banned in many high-income countries following confirmed studies of fatal agranulocytosis and adverse drug reactions, it is still widely used in various countries of the world. However, the antipyretic therapeutic indications of dipyrone in febrile children are currently unknown, and there is little information on the advantages and disadvantages of using dipyrone in febrile youngsters. In febrile youngsters, we expected that dipyrone's antipyretic effectiveness wouldn't be any more effective than ibuprofen. Therefore, the purpose of this research is to evaluate the effectiveness of oral dipyrone and oral ibuprofen as antipyretics in febrile children.
Methods
Several databases, including PubMed, Scopus, Web of Science, and Cochrane Library, were searched thoroughly using a pre-established search strategy for potential research. The studies included in this analysis comprised randomized controlled trials that compared the antipyretic effects of oral ibuprofen and oral dipyrone in febrile kids. Data analysis was carried out using Revman 5.4 software.
Results
Three studies were selected among the 27 publications we discovered to be applicable, and they underwent qualitative and quantitative analysis. The pooled analysis revealed no discernible difference between oral dipyrone and oral ibuprofen in terms of their antipyretic effects (Mean difference (MD) = 0.06; 95% confidence interval (CI): -0.08, 0.20).
Conclusion
Both oral dipyrone and ibuprofen are effective in reducing high-temperature levels in febrile children without any significant difference.
Development of a multivariable prediction model for necrotizing enterocolitis stage III
or mortality within a week among preterm infants at the time of initial evaluation
for necrotizing enterocolitis: A retrospective cohort study
Authors: Nayak Sulir , Sanchez-Rosado Mariela , Brown L Steven , Mangona Kate Louise , Sharma Priya , Reis Jordan , Nelson David , Wyckoff Myra , Pandya Samir , Mir Imran , Brion Luc 
Published: June 2023

Abstract
Objective: This study was designed to develop a multivariate prediction model using variables obtained at the time of sepsis evaluation to predict necrotizing enterocolitis (NEC) stage III or death within a week with an area under the curve (AUC)>0.90.
Study design: This is a retrospective cohort study (n=269) of preterm infants <33 weeks' gestation or <1500 grams birthweight either suspected or with NEC born at Parkland Health between 2009-2021. A multivariate prediction model using the new PACSOFAH score (Pneumoperitoneum, Abdominal Compartment Syndrome, Neonatal Sequential Organ failure Assessment (NSOFA) score, acidemia, hyperkalemia, hyperglycemia), gestational age and use of inotropes for hypotension during the prior week was compared with a similar model using NSOFA score.
Results: The PACSOFAH-model had a greater AUC than the NSOFA-model (0.92 vs 0.85, respectively, P=0.0005).
Conclusion: A new prediction model for death or NEC stage III was developed with AUC=0.92 at the time of initial sepsis evaluation.
Nonlinear Behavior of Quasi-zero Stiffness Nonlinear Torsional Vibration Isolator
Authors: Xu Jiawei , Jing Jianping 
Published: June 2023

Abstract
This paper researches the nonlinear behavior of a nonlinear torsional vibration isolator (NTVI) which is composed of flexible rod element and electromagnetic element. And the NTVI has a quasi-zero stiffness (QZS) characteristic. Firstly, a statics model of the QZS-NTVI is established and the effects of geometric parameters on the QZS behavior and restoring torque are described. Then, the statics model approximated by the Taylor series is incorporated into the dynamic model of QZS-NTVI. The stability of the harmonic solution is analyzed and the amplitude-frequency response and the torque transmissibility curves under different geometric parameters are derived according to the harmonic balance method. Furthermore, numerical analysis effort is performed to study the nonlinear behavior of QZS-NTVI. The results show that the QZS-NTVI exhibits super-harmonic and sub-harmonic resonances and undergoes the periodic and chaotic motions alternatively with the change in the excitation amplitude and the angular frequency. Finally, both the simulation and experimental efforts are performed to validate the statics model of the flexible rod and to study the vibration isolation performance and nonlinear behavior of QZS-NTVI. The results demonstrate that the vibration isolation performance of QZS-NTVI notably outperforms the linear system, as well as nonlinear behavior with frequency jump.
Identification of EMT-related gene signatures in glioblastoma to aid immunotherapy and prognosis
Authors: Li Chengcai , Diao Bo , Ning Weihai , Song Dixiang , Liu Deshan , Zhang Hongwei 
Published: June 2023

Abstract
Objective: Glioblastoma (GBM) is the most aggressive malignancy of the central nervous system, with the lowest survival rate of malignant brain tumors at approximately 6%. Epithelial mesenchymal transition (EMT) is closely associated with tumor metastasis and drug resistance. Therefore, it is necessary to construct models consisting of EMT-related genes (ERGs) to forecast prognosis and benefit from immunotherapy in GBM patients.
Methods: To identify differentially expressed genes (DEGs) for GBM by TCGA, CGGC, and GEO databases. To collect ERGs, databases called dbEMT2 and MSigDB were employed. Weighted gene co-expression network analysis (WGCNA) was used to find the core differentially expressed EMT-related genes (CDEERGs) at the junction of DEGs and ERGs. We developed the CDEERGs prognosis model (CPM) using a variety of bioinformatics analysis methods. The CPM was employed to determine risk scores for patients in TCGA-GBM dataset, and CGGC-325 and CGGC-693 datasets were utilized to externally validate the CPM's predictive ability. The differences in immunological traits and immunotherapeutic indicators between different groups were compared. Finally, it was evaluated if CPM may be helpful for determining whether immunotherapy would be appropriate for oncology patients.
Results:IGFBP2, RGS4, AGTR1, CCL5, and LOXL1 were the five risk factors and ACTL6A and MTHFD2 were the two protective factors in the CPM. Patients with GBM were separated into high-risk and low-risk subgroups according on median risk scores. Low-risk subgroup in the TCGA-GBM dataset was significantly better than that in high-risk subgroup, and prognosis of patients in CGGC-325 and CGGC-693 datasets remained consistent with that in TCGA-GBM dataset. Risk scores and the expression of CD274 and PDCD1 were positively associated, and CD274 expression was higher in high-risk subgroup than in low-risk subgroup. The expression of numerous immunotherapy markers was different in high-risk and low-risk subgroups. Compared to the other prognostic models, the CPM has greater predictive power. We discovered that patients with low-risk scores may be better candidates for immunotherapy by calculating the risk scores of patients in the IMvigor210 dataset.
Conclusion: The present study constructs CPMs that could be used to predict the prognosis of GBM patients as well as to screen for patients who can benefit from immunotherapy and to screen for CDEERGs that may provide new therapeutic targets for the treatment of GBM patients.
Lower limb venous thrombosis among breast cancer patients receiving tamoxifen in Uganda
Authors: Vincent Mboizi , Sereke Senai Goitom , Ameda Faith , Richard Okello Omara , Alfred Bulamu 
Published: June 2023

Abstract
Background
Tamoxifen therapy is an effective and mainstay adjuvant treatment for estrogen-positive breast cancer patients. However, it has partial estrogen receptor agonist activity that causes hypercoagulation of blood and consequently venous thrombus formation. Patients who are being treated with tamoxifen require monitoring, because of the increased risk for developing deep venous thrombosis (DVT) and pulmonary embolism that could increase morbidity and mortality if left undiagnosed. This study sought to determine the prevalence and associated factors of lower limb DVT among breast cancer patients on tamoxifen, in Uganda.
Methods
This was a cross-sectional study done among patients receiving tamoxifen therapy who attended the breast clinic at the Uganda Cancer Institute. Clinical evaluation, mean platelet volume (MPV) and bilateral lower limb compression and Doppler ultrasound scans were done to screen for DVT. Univariate analysis was used to summarize continuous variables as mean and corresponding standard deviations, and categorical variables as proportions.
Results
Of the 180 participants, 170 (94.4%) were females, 141 (78.3%) were below 60 years. More than 95% were neither diabetic nor smokers and 163 (90.6%) of them had a BMI of < 35Kg/m2. The prevalence of DVT was 0.6%. The statistical significance of the associated factors could not be elucidated at bivariate or multivariate analysis due to the very low prevalence of DVT.
Conclusion
The prevalence of DVT among breast cancer patients on tamoxifen at the Uganda cancer institute was very low (0.6%). The patients with normal MPV findings are unlikely to have DVT despite the intermediate risk on clinical assessment, therefore a routine sonographic examination for younger Ugandan patients on tamoxifen may not be necessary.
Psychometric evaluation of the Chinese version of Self-assessment scale for the community- based and emergency practice among medical students
Authors: Zheng Chen , Li Xia , Yu Jie , Zhang Huijun 
Published: June 2023

Abstract

Objective As the population continues to age, community-based primary care for the elderly increases to an important level. The aim of this study was to translate the Self-assessment scale for the community- based and emergency practice (C-CEP) into Chinese and to test its reliability and validity among medical students. Methods After gaining access to the C-CEP scale, the Brislin translation-back translation model was used for translation and cross-cultural adaptation. 600 medical students were recruited to participate in this study using a convenience sampling method (n = 600). General information about the study population was analyzed by descriptive statistics; item analysis was used to screen the scale items; the reliability of the Chinese version of the questionnaire was measured by internal consistency, split-half reliability, and retest reliability; the validity of the questionnaire was measured by content validity and structural validity. Results The English version of the C-CEP consisted of 15 items and the analysis of the items showed that all indicators were met. The Cronbach's alpha for the translated scale was 0.933 and the range of Cronbach's alpha for each dimension was 0.927–0.931. The retest reliability was 0.754 and the split-half reliability was 0.883. The four-factor structure explained a cumulative 74.897% of the total variance. All the content validity was met. The results of the validation factor analysis showed that χ²/ df = 1.906, RMR = 0.031, GFI = 0.931, AGFI = 0.901, IFI = 0.974, TLI = 0.967, CFI = 0.973, PNFI = 0.757, PGFI = 0.651 and RMSEA = 0.055. The model-fit indicators were all within acceptable limits. Conclusions The Chinese version of the Self-assessment scale for the community- based and emergency practice had good reliability and validity and could effectively assess medical students' self-practice skills. The scale could provide intervention targets for medical educators to explore the direction of community practice education for medical students to improve their practice emergencies.
Numerical Solutions of Fractional Diffusion Equation of Jeffrey’s Flow
Authors: Khan Abdul Quayam , Ahmed Ali , Wahid Abdul , Anwar Muhammad Shoaib 
Published: June 2023

Abstract
In this article, we conducted a numerical study on the solution of the fractional diffusion equations combined with the temperature equation. These are one-dimensional coupled parabolic equations with a fractional derivative solved by the finite element method and the finite difference method. We applied the fractional Caputo operator to the Jeffrey fluid model equation and obtained the fractional diffusion equation as a result. Fractional differential terms are solved by the finite difference method, and non-fractional derivatives are solved by the finite element method. Numerical convergence of the scheme is applied through theoretical error estimation and the system is analyzed graphically. An algorithm simulated in MATLAB that graphs the results of various dimensionless physical and fractional parameters.
Analysis of the Manufacturing Porosity in Additively Manufactured Onyx/Long Fiber Reinforced Composites Using X-Ray Computed Tomography
Authors: Pace Francesco , Stamopoulos Antonios G. , Eckl Michael , Senck Sascha , Glinz Jonathan 
Published: June 2023

Abstract
Nowadays, additive manufacturing techniques such as the Fused Filament Fabrication appear to be among the most promising additive manufacturing methods for enabling modern industry to produce components of high geometrical complexity. The main characteristic of this method is the deposition of thermoplastic polymers that can be further reinforced with chopped and/or continuous fibers that attributes to the product some unique structural characteristics. Nevertheless, the process is susceptible to a variety of defects that are derived from the fabrication process parameters, such as porosity, insufficient fiber impregnation with the polymer and fiber disorientation. On the other hand, since the applicability of the process depends on the development of numerical tools for assessing the effects of these defects, the accurate detection and quantification of them is a crucial part of it. In the present work, these defects are studied experimentally by implementing an X-Ray computed tomography testing campaign. The manufacturing defects, as a form of initial damage, are identified using well-established techniques while a complete analysis of the distribution of porosity is presented for various zones of Onyx, Onyx/Carbon and Onyx/Glass fiber reinforced structures. Finally, the tendency of the overall pore content to increase with increasing number of continuous fiber reinforcement was identified as well as porosity variations in printing direction are presented.
Electron beam lithography of GeTe through polymorphic phase transformation
Authors: Zhang Hu , Li Meng , Cheng Shao-Dong , Lu Lu , Chen Zhi-Gang , Ye Hengqiang , Mi Shao-Bo 
Published: June 2023

Abstract

Finding new phases can deeply understand the fundamental of materials and broaden their practical applications. Here, we report two undiscovered phases of GeTe including the zinc-blende (c-) phase and the hexagonal (h-) phase with interlayer van der Waals gaps. A polymorphic phase transformation from rhombohedral α-GeTe to c- and h-GeTe near room temperature, then supposedly to cubic β-GeTe at higher temperature, is first realized via electron beam irradiation. Theirunderlying thermodynamics and kinetics are illustrated by the in-situ heating experiments and molecular dynamics simulation. Density-functional theory calculation indicates that c-GeTe exhibits typical metallic behavior and h-GeTe is a narrow-gap semiconductor with a strong spin-orbital coupling effect. An atomic-scale electron beam lithography technique is finally developed and adopted to fabricate GeTe-based quantum devices compromising nanopillars and heterostructures of c- and h-GeTe in α-GeTe matrix.
Efficacy of Cymbopogon citratus extract (Spotless 1% Gearniol EC) against different plant pathogens and its gene expression
Authors: Priya R , Murugesan N V , Ramakrishnan P , K Latha , Narayanasamy Prabhakaran 
Published: June 2023

Abstract
Uncontrolled usage of synthetic fungicides has generated toxicological and environmental hazards. Essential oils are gaining popularity despite their extensive use as scents. To establish novel applications in human health, agriculture, and the environment, it's crucial to understand their biological action. Botanical insecticides are gaining popularity around the world. In this work, a botanical biocide (Cymbopogon citratus extract-Spotless 1% Gearniol EC) was investigated for its in vitro and in vivo efficiency against several plant pathogens. 0.2% was shown to be the most effective in treating bacterial and fungal pathogens with maximum inhibition. Relative electric conductivity (REC) grew with prolonged product use, showing the product was more effective. In vivo experiments showed a 15% increase in shoot height, panicle number, and grain output in paddy at 2.0 ml per litre of water. Cymbopogon citratus extract (Spotless 1% Gearniol EC) could be used as an alternative to synthetic biocides to prevent or control crop diseases caused by bacteria and fungi.
Reproductive interference between alien species in Veronica
Authors: Nishida Sachiko , Tamakoshi Naoko , Takakura Ko-Ichi , Watanabe Yuta , Kanaoka Masahiro M 
Published: June 2023

Abstract
Reproductive interference can lead to the exclusive distribution of species. Although interference from alien to native species has been reported, reports on reproductive interference between alien species are scarce. However, because alien species are becoming more abundant, evaluations of reproductive interference between aliens and its influence on community structure are essential. We therefore investigated the presence of interference in two alien species of Veronica, V. cymbalaria and V. persica. Hand-pollination experiments revealed that heterospecific pollen adversely affected both species, but asymmetrically: in V. cymbalaria, it reduced the number of seeds both before and after conspecific pollination, but in V. persica it reduced the number of seeds only when it occurred before conspecific pollination. Field observation showed that the number of seeds produced by V. cymbalaria decreased when the frequency of surrounding V. persica flowers increased. However, this association could be due to the positive effect on seed set of conspecific flowers. Pot experiments showed that the presence of heterospecific individuals did not lead to reductions in the number of seeds in either species. Observations of visiting pollinators revealed no pollinator preference between the plant species. Although we demonstrated asymmetrical reproductive interference between V. cymbalaria and V. persica, its effect in the field seemed limited. An essential factor mitigating the adverse effect of reproductive interference might be a shortage of pollinators that might facilitate interspecific pollination. This issue needs to be further investigated in the future.
Pathological and Molecular Analysis of Spontaneous Canine Mammary Carcinomas and its Prognostic implications
Authors: Kuppusamy Krithiga , Rajan Arathi , Varghese Geetu Rose , Latha Neetha Rajan , Krishnan Neethu , Patra Dipyaman , Warrier Arathy , Bhushan Satej , Nair Narayanan Divakaran , Srini Priya 
Published: June 2023

Abstract
Purpose: The canine mammary tumours (CMT) and human breast cancers (HBC) are postulated to resemble each other in genesis, progression, presentation and prognostication. Thus, studies involving naturally occurring CMT may aid in better understanding of HBC. The study also aims at replicating the techniques used to study the HBC in CMT and to find whether the canine model can be utilized for HBC research and also provide diagnostic methods for patients with CMT.
Methods: Samples from spontaneous CMT cases were collected and a cohort of canine mammary carcinomas (CMC) was utilised for this study after histopathological examination and grading. Immunophenotyping and identifying the cancer stem cells (CSC) which are the most acclaimed cause of recurrence, metastasis, and treatment failures in CMC was performed by using suitable markers.
Results: Expression of CD44+/24-/low CSC phenotype, CD24 overexpression, ALDH1 in higher grades, decreased E cadherin and increased N cadherin in recurrence/ metastasis were observed by immunohistochemistry. The qRTPCR results showed increased Oct-4, Sox-2, Nanog expression in higher grades of tumours, while the E and N cadherin switch was observed in recurrent/ metastatic cases. A survival analysis of a 36 months follow-up study revealed that prognosis was poor in patients with higher grades and in CMC with CD44+/24-/low or CD24 overexpression.
Conclusion: It could be deciphered from the study that the human and canine breast cancers share common diagnostic and prognostic signatures and can serve as better model to study the human disease.
Comparison of plantar deformation and damping behavior in different areas of plantar tissue in relaxed and tense muscular state
Authors: Paul Benedikt , Senner Veit , Compeyron Robin , Mitternacht Jürgen , Gelsinova Lora 
Published: June 2023

Abstract
During gait, the cushioning function of the soft tissue on the sole of the foot plays a pivotal role, which is particularly evident when this function is limited due to the lack of these complex structured fat tissue chambers. Therefore, further research of the biomechanics of this tissue is conducted. A technique to determine the effective Young's modulus, the spring constant, and the absorbed energy during impact on the sole of the foot is used to investigate these parameters at four different plantar measurement points. Vertical in vivo impact tests and ultrasonic tissue examinations were used on the right feet of n = 19 study participants for this purpose. Measurements were conducted under the calcaneus, under the first metatarsal head, in the area between the fourth and fifth metatarsal head, and the plantar section of the tendon of the flexor hallucis longus. Measurements were taken both in a relaxed and in a tense muscular state in order to gain insights into the relationship between plantar elasticity and muscular activity. The effective Young's modulus showed a significant (P from 0.0442 to > 0.001) increase at all points in the tense state, while the spring constant rose at just three. Energy absorption decreased significantly (P between 0.04 and 0.002) at all points except for the subcalcaneal region. This provided information may help for further understanding of foot biomechanics and in the development of new tailored damping systems for shoes or insoles.