bluuebunny/crossref_metadata_2025_split huggingface dataset:
INPP5E regulates CD3ζ enrichment at the immune synapse by phosphoinositide distribution control
Authors: Chiu Tzu-Yuan , Lo Chien-Hui , Lin Yi-Hsuan , Lai Yun-Di , Lin Shan-Shan , Fang Ya-Tian , Huang Wei-Syun , Huang Shen-Yan , Tsai Pei-Yuan , Yang Fu-Hua , Chong Weng Man , Wu Yi-Chieh , Tsai Hsing-Chen , Liu Ya-Wen , Hsu Chia-Lin , Liao Jung-Chi , Wang Won-Jing 
Published: September 2023

AbstractThe immune synapse, a highly organized structure formed at the interface between T lymphocytes and antigen-presenting cells (APCs), is essential for T cell activation and the adaptive immune response. It has been shown that this interface shares similarities with the primary cilium, a sensory organelle in eukaryotic cells, although the roles of ciliary proteins on the immune synapse remain elusive. Here, we find that inositol polyphosphate-5-phosphatase E (INPP5E), a cilium-enriched protein responsible for regulating phosphoinositide localization, is enriched at the immune synapse in Jurkat T-cells during superantigen-mediated conjugation or antibody-mediated crosslinking of TCR complexes, and forms a complex with CD3ζ, ZAP-70, and Lck. Silencing INPP5E in Jurkat T-cells impairs the polarized distribution of CD3ζ at the immune synapse and correlates with a failure of PI(4,5)P2clearance at the center of the synapse. Moreover, INPP5E silencing decreases proximal TCR signaling, including phosphorylation of CD3ζ and ZAP-70, and ultimately attenuates IL-2 secretion. Our results suggest that INPP5E is a new player in phosphoinositide manipulation at the synapse, controlling the TCR signaling cascade.
Inhibition of ACSL4 ameliorates tubular ferroptotic cell death and protects against fibrotic kidney disease
Authors: Dai Yue , Chen Yuting , Mo Dexiameng , Jin Rui , Huang Yi , Zhang Le , Zhang Cuntai , Gao Hongyu , Yan Qi 
Published: September 2023

AbstractFerroptosis is a recently recognized form of regulated cell death, characterized by iron-dependent accumulation of lipid peroxidation. Ample evidence has depicted that ferroptosis plays an essential role in the cause or consequence of human diseases, including cancer, neurodegenerative disease and acute kidney injury. However, the exact role and underlying mechanism of ferroptosis in fibrotic kidney remain unknown. Acyl-CoA synthetase long-chain family member 4 (ACSL4) has been demonstrated as an essential component in ferroptosis execution by shaping lipid composition. In this study, we aim to discuss the potential role and underlying mechanism of ACSL4-mediated ferroptosis of tubular epithelial cells (TECs) during renal fibrosis. The unbiased gene expression studies showed that ACSL4 expression was tightly associated with decreased renal function and the progression of renal fibrosis. To explore the role of ACSL4 in fibrotic kidney, ACSL4 specific inhibitor rosiglitazone (ROSI) was used to disturb the high expression of ACSL4 in TECs induced by TGF-β, unilateral ureteral obstruction (UUO) and fatty acid (FA)-modeled mice in vivo, and ACSL4 siRNA was used to knockdown ACSL4 in TGF-β-induced HK2 cells in vitro. The results demonstrated that inhibition and knockdown of ACSL4 effectively attenuated the occurrence of ferroptosis in TECs and alleviated the interstitial fibrotic response. In addition, the expression of various profibrotic cytokines all decreased after ROSI-treated in vivo and in vitro. Further investigation showed that inhibition of ACSL4 obviously attenuates the progression of renal fibrosis by reducing the proferroptotic precursors arachidonic acid- and adrenic acid- containing phosphatidylethanolamine (AA-PE and AdA-PE). In conclusion, these results suggest ACSL4 is essential for tubular ferroptotic death during kidney fibrosis development and ACSL4 inhibition is a viable therapeutic approach to preventing fibrotic kidney diseases.
Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency
Authors: Tsai Yu-Young , Shen Chiu-Lun , D Dhananjaya , Tsai Ching-Yen , Tarn Woan-Yuh 
Published: September 2023

AbstractA molecular and functional link between neurotrophin signaling and cerebellar foliation is lacking. Here we show that constitutive knockout of two homologous genes encoding the RNA binding protein RBM4 results in foliation defects at cerebellar lobules VI–VII and delayed motor learning in mice. Moreover, the features of Rbm4 double knockout (dKO), including impaired differentiation of cerebellar granule cells and dendritic arborization of Purkinje cells, are reminiscent of neurotrophin deficiency. Loss of RBM4 indeed reduced brain-derived neurotrophic factor (BDNF). RBM4 promoted the expression of BDNF and full-length TrkB, implicating RBM4 in efficient BDNF-TrkB signaling. Finally, prenatal supplementation with 7,8-dihydroxyflavone, a TrkB agonist, restored granule cell differentiation, Purkinje cell dendritic complexity and foliation—the intercrural fissure in particular—in the neonatal cerebellum of Rbm4dKO mice, which also showed improved motor learning in adulthood. This study provides evidence that prenatal activation of TrkB signaling ameliorates cerebellar malformation caused by BDNF deficiency.
Integrated aquatic and terrestrial food production enhances micronutrient and economic productivity for nutrition-sensitive food systems
Authors: Ignowski Liz , Belton Ben , Ali Hazrat , Thilsted Shakuntala Haraksingh 
Published: September 2023

AbstractIntegrated aquaculture–agriculture (IAA) is a form of crop diversification where aquatic and terrestrial foods are grown together on a single parcel of land. We compare economic and nutrient productivity per hectare for 12 distinct IAA combinations, identified from a representative survey of 721 farms in southern Bangladesh. Just under half of households integrate agriculture into their aquaculture production. Regression analyses show positive associations between the integration of terrestrial foods into aquatic farming systems and nutrient productivity, but that nutrient productivity is partly disconnected from economic productivity. However, we find that production of specific combinations of aquatic foods and vegetables can simultaneously improve nutrient productivity and economic productivity, thereby promoting nutrition-sensitive agriculture (NSA). The approach demonstrated here can be applied to the design of NSA programmes that are important for realizing nutrition-sensitive food systems.
Tightly bound and room-temperature-stable excitons in van der Waals degenerate-semiconductor Bi4O4SeCl2 with high charge-carrier density
Authors: Xu Yueshan , Wang Junjie , Su Bo , Deng Jun , Peng Cao , Wu Chunlong , Zhang Qinghua , Gu Lin , Luo Jianlin , Xu Nan , Guo Jian-gang , Chen Zhi-Guo 
Published: September 2023

AbstractExcitons, which represent a type of quasi-particles consisting of electron-hole pairs bound by the mutual Coulomb interaction, are often observed in lowly-doped semiconductors or insulators. However, realizing excitons in semiconductors or insulators with high charge-carrier densities is challenging. Here, we perform infrared spectroscopy, electrical transport, ab initio calculations, and angle-resolved-photoemission spectroscopy study of the van der Waals degenerate-semiconductor Bi4O4SeCl2. A peak-like feature (α peak) is present around ~125 meV in the optical conductivity spectra at low temperature T = 8 K and room temperature. After being excluded from the optical excitations of free carriers, interband transitions, localized states and polarons, the α peak is assigned as an exciton absorption. Assuming the existence of weakly-bound Wannier-type excitons in this material violates the Lyddane-Sachs-Teller relation. Moreover, the exciton binding energy of ~375 meV, which is about an order of magnitude larger than those of conventional semiconductors, and the charge-carrier concentration of ~1.25 × 1019 cm−3, which is higher than the Mott density, further indicate that the excitons in this highly-doped system should be tightly bound. Our results pave the way for developing optoelectronic devices based on tightly bound and room-temperature-stable excitons in highly-doped van der Waals degenerate semiconductors.
MXene-reduced graphene oxide sponge-based solar evaporators with integrated water-thermal management by anisotropic design
Authors: Liu Zonglin , Ding Renjie , Xue Fuhua , Zhao Xu , Chen Zhong , Zheng Haowen , Li Pengyang , Yan Qian , Xu Liangliang , Xiong Jinhua , Peng Qingyu , He Xiaodong 
Published: September 2023

AbstractThe main issue limiting the performance of the solar evaporators is that water-thermal management is difficult to coordinate. Herein, we achieve integrated water-thermal management by designing hierarchical MXene-reduced graphene oxide sponges with anisotropic thermal conductivity and axial-directional water conveyance channels. The reduced graphene oxide acts as the sponge framework and carbon source for in situ synthesis of MXenes on the surface. The axial-oriented framework supports the structure and provides fast water transmission channels to the air-water interface. Meanwhile, the MXene nanosheets are vertically aligned on the framework surface, making the radial thermal conductivity of the sponges much greater than the axial one, which suppresses heat loss in the axial direction. The material exhibits an evaporation rate of 2.35 kg m−2 h−1 under one sunlight and maintains 85 % energy efficiency under weak sunlight (0.5-sun). Furthermore, the sponge shows a long working life with 96 % evaporation rate retention after a 30-day-sustained operation.
The ephemeral history of Earth’s youngest supra-subduction zone type ophiolite from Timor
Authors: Lin Yu-Chin , Chung Sun-Lin , Maruyama Shigenori , Kadarusman Ade , Lee Hao-Yang 
Published: September 2023

AbstractOphiolites occur widely in orogenic belts, yet their origins remain controversial. Here we present a modern example with a geodynamic model from Timor, eastern Indonesia, where Earth’s youngest supra-subduction zone (SSZ)-type ophiolitic fragments are exposed. Zircon U-Pb ages and geochemical data indicate a short timespan (~10 to 8 Ma) for the magmatic sequence with boninitic and tholeiitic arc compositions. We interpret the Timor ophiolite as part of the infant Banda arc-forearc complex, which formed with the opening of the North Banda Sea and subsequent arc-continent collision along the irregular Australian continental margin. Our study connects the occurrence of small, short-lived ocean basins in the western Pacific with orogens around the globe where ephemeral SSZ-type ophiolites occur. These orogenic ophiolites do not represent preexisting oceanic crust, but result from upper-plate processes in early orogenesis and thus mark the onset of collision zone magmatism.
Moon’s high-energy giant-impact origin and differentiation timeline inferred from Ca and Mg stable isotopes
Authors: Fu Hairuo , Jacobsen Stein B. , Sedaghatpour Fatemeh 
Published: September 2023

AbstractMass-dependent stable isotopic variations recorded in lunar samples provide novel resolution to the formation and differentiation history of the Moon. In this study, we report new high-precision Ca-isotope measurements for lunar rocks and minerals. Ca-isotope data and modeling of the lunar magma ocean together demonstrate indistinguishable mass-dependent Ca isotopic compositions of the bulk silicate Earth and Moon. This implied Earth-Moon isotope equilibration is consistent with the Moon’s high-energy giant-impact (Synestia) origin and not readily compatible with the traditional giant-impact models. Moreover, a cross-comparison between Ca and Mg isotopic data for an important anorthosite sample (60025) consistently clarifies its formation near the completion of the lunar magma ocean crystallization. Therefore, the various existing radiometric dating for 60025 sets the lunar magma ocean to have fully solidified by either 4.51 or 4.38 billion years ago, constraining the two respective lunar differentiation timescales to <30 (short-lived) or ~130–150 (long-lived) million years.
Abrupt, climate-induced increase in wildfires in British Columbia since the mid-2000s
Authors: Parisien Marc-André , Barber Quinn E. , Bourbonnais Mathieu L. , Daniels Lori D. , Flannigan Mike D. , Gray Robert W. , Hoffman Kira M. , Jain Piyush , Stephens Scott L. , Taylor Steve W. , Whitman Ellen 
Published: September 2023

AbstractIn the province of British Columbia, Canada, four of the most severe wildfire seasons of the last century occurred in the past 7 years: 2017, 2018, 2021, and 2023. To investigate trends in wildfire activity and fire-conducive climate, we conducted an analysis of mapped wildfire perimeters and annual climate data for the period of 1919–2021. Results show that after a century-long decline, fire activity increased from 2005 onwards, coinciding with a sharp reversal in the wetting trend of the 20th century. Even as precipitation levels remain high, moisture deficits have increased due to rapid warming and increased evaporative demand. Bottom-up factors further influence fire activity, as the legacy of past wildfires, insect outbreaks, and land-use practices continually influence fire regimes. The compound effects of climate-induced moisture changes and altered fuels now force British Columbians to confront the harsh reality of more frequent years of intense and prolonged wildfire activity.
A unified approach for the thermodynamic comparison of heat pump cycles
Authors: Yu Zhibin , Ouderji Zahra Hajabdollahi 
Published: September 2023

AbstractThe flexible heat pump cycle introduces a heat storage device into the Evans-Perkins cycle to recover, store, and reuse part of the sensible heat carried by the hot liquid refrigerant from the condenser, achieving a higher coefficient of performance than the latter. In this paper, we develop a unified approach, namely cycle superposition to allow comparison of the flexible heat pump cycle with other performance-enhancing cycle layouts including two-stage cycles with intercooling, subcooling, flash gas removal, or their combinations. We show that under ideal conditions, the flexible heat pump cycle is thermodynamically similar to two-stage heat pump cycles with full subcooling or flash gas removal, but no intercooling. From the energy recovery perspective, the two-stage cycles recover and reuse some sensible heat carried by hot liquid refrigerant simultaneously using their high-stage compressor, whereas the flexible heat pump cycle decouples the recovery and reuse of such heat in time using a heat storage. However, the irreversible heat transfer via real heat exchangers during charging and discharging processes will reduce the benefits of the flexible heat pump cycle. The effectiveness of all these performance-enhancing methods strongly depends on the characteristics of refrigerants.
Gut microbiota profile and the influence of nutritional status on bacterial distribution in diabetic and healthy Tunisian subjects
Authors: Fassatoui Meriem , Saffarian Azadeh , Mulet Céline , Jamoussi Henda , Gamoudi Amel , Ben Halima Yosra , Hechmi Meriem , Abdelhak Sonia , Abid Abdelmajid , Sansonetti Philippe J. , Pedron Thierry , Kefi Rym 
Published: September 2023

Abstract
Gut microbiota plays a key role in the regulation of metabolism and immunity. We investigated the profile of gut microbiota and the impact of dietary intake on gut bacterial distribution in diabetic and healthy Tunisian subjects, aiming to identify a dysbiotic condition, hence opening the way to restore eubiosis and facilitate return to health. In the present research, we enrolled 10 type 1 diabetic (T1D), 10 type 2 diabetic (T2D) patients and 13 healthy (H) subjects. Illumina Miseq technology was used to sequence V3-V4 hypervariable regions of bacterial 16SrRNA gene. Data were analyzed referring to QIIME 2 pipeline. RStudio software was used to explore the role of nutrition in gut bacterial distribution. At the phylum level, we identified an imbalanced gut microbiota composition in diabetic patients marked by a decrease in the proportion of Firmicutes and an increase in the abundance of Bacteroidetes compared with H subjects. We observed higher amounts of Fusobacteria and a decline in the levels of TM7 phyla in T1D patients compared with H subjects. However, we revealed a decrease in the proportions of Verrucomicrobia in T2D patients compared with H subjects. At the genus level, T2D subjects were more affected by gut microbiota alteration, showing a reduction in the relative abundance of Faecalibacterium, Akkermansia, Clostridium, Blautia and Oscillibacter, whereas T1D group shows a decrease in the proportion of Blautia. The gut bacteria distribution was mainly affected by fats and carbohydrates consumption. Gut microbiota composition was altered in Tunisian diabetic patients and affected by dietary habits.
Factors Associated With Hearing Aid Outcomes Including Social Networks, Self-Reported Mental Health, and Service Delivery Models
Authors: Mothemela Bopane , Manchaiah Vinaya , Mahomed-Asmail Faheema , Graham Marien , Swanepoel De Wet 
Published: September 2023

Purpose:
This study aims to identify and describe factors that influence hearing aid outcomes including social networks, self-reported mental health, and service delivery models.

Method:

A prospective cross-sectional online survey was sent to hearing aid users recruited through an online platform (
http://www.hearingtracker.com
) between October and November 2021. The survey contained questions on patient demographics, audiological variables, general health and social factors, and self-reported hearing aid outcomes using the International Outcome Inventory for Hearing Aids (IOI-HA). Regression models evaluated potential contributing factors of hearing aid outcomes on the IOI-HA.

Results:

Three hundred ninety-eight hearing aid users completed the survey with an average age of 66.6 (
SD
= 13.0) years, of which 59.3% were male. Positive contributing factors of hearing aid outcomes (IOI-HA total score) were social network of people with hearing loss with hearing aids (
p
< .010; Exp[B] = 0.03, 95% CI [0.01, 0.1]), self-reported mental health (
p
< .05; Exp[B] = 0.6, 95% CI [0.01, 1.2]), work situation (
p
< .001; Exp[B] = 1.9, 95% CI [0.7, 2.8]), quality of life (
p
< .005; Exp[B] = 1.2, 95% CI [0.3, 1.1]), and self-reported hearing difficulty (
p
< .02; Exp[B] = 0.8, 95% CI [0.2, 1.5]). Negative contributing factors of hearing aid outcomes included social networks of people with hearing loss without hearing aids (
p
< .001; Exp[B] = −0.1, 95% CI [−0.2, −0.2]) and service delivery model of private or university clinic compared to big-box retailers (
p
< .001; Exp[B] = −1.6, 95% CI [−2.7, −0.7]).

Conclusions:
Novel factors including social network of persons with hearing loss who use hearing aids, self-reported mental health, service delivery model, and work situation are significant contributors to hearing aid outcomes. These newly identified factors can inform public hearing health promotion and individualized audiological care to optimize hearing aid outcomes.

Supplemental Material:

https://doi.org/10.23641/asha.24060486
Motor Performance During Sensorimotor Training for Airway Protection in Parkinson's Disease
Authors: Borders James C. , Hegland Karen W. , Vanegas-Arroyave Nora , Troche Michelle S. 
Published: September 2023

Introduction:
Cough dysfunction is highly prevalent in Parkinson's disease (PD) and associated with pneumonia, a leading cause of death. Although research suggests that cough can be volitionally upregulated, patterns of improvements that occur during cough skill training and potential correlates remain unexamined. Therefore, we sought to characterize changes to peak flow during cough skill training, examine whether early variability predicted motor performance trajectories during treatment, and explore the relationship between peak flow during cough skill training and motor learning on a similar but untrained task (i.e., reflex cough testing).

Method:
This secondary analysis of treatment data from a randomized controlled trial included 28 individuals with PD who participated in five sessions of sensorimotor training for airway protection (smTAP). During this novel cough skill training, participants completed 25 repetitions of coughs targeting peak flow 25% above their baseline. Reflex and voluntary cough testing was performed pre- and posttreatment. Bayesian multilevel growth curve models provided group and individual-level estimates of peak flow during training.

Results:
The magnitude and consistency of peak flow increased during cough skill training. Variability in peak flow during the first treatment session was associated with greater improvements to peak flow in later sessions. There was no relationship between changes to peak flow during cough skill training and motor learning.

Conclusions:
Individuals with PD improved the strength and variability of cough peak flow during cough skill training. These findings provide a clinically relevant characterization of motor performance during cough skill training and lend insight into potential correlates to guide future treatment paradigms.
Hyolaryngeal Movement During Normal and Effortful Swallows Determined During Ultrasonography
Authors: Bahia Mariana M. , Lowell Soren Y. 
Published: September 2023

Purpose:
This study investigated (a) the effects of the effortful swallow under two different instructions (tongue emphasis vs. pharyngeal squeezing) on hyoid displacement and hyoid–larynx approximation, (b) the association between tongue pressure and hyolaryngeal movement during normal swallowing and the effortful swallow produced with tongue emphasis, and (c) age-related differences in hyolaryngeal movement during normal and effortful swallows (tongue emphasis vs. pharyngeal squeezing) in healthy individuals.

Method:
Forty healthy adults (20 younger and 20 older) swallowed their saliva as they normally do (normal swallow) and performed the effortful swallow with tongue emphasis and pharyngeal squeezing. Tongue-to-palate pressure during swallowing was measured using the Iowa Oral Performance Instrument, hyolaryngeal movement was measured using ultrasonography, and submental surface electromyography was used to track swallows.

Results:
Results revealed differences in hyolaryngeal movement across swallowing types. Both types of effortful swallows showed greater hyolaryngeal movement than normal swallows. Additionally, hyolaryngeal movement was greater during the effortful swallow with tongue emphasis than the effortful swallow with pharyngeal squeezing. Age-related differences were found only in hyoid–larynx approximation during the effortful swallow with tongue emphasis (younger > older adults). Furthermore, moderate positive correlations were identified between tongue pressure and hyolaryngeal movement during normal swallows and the effortful swallow with tongue emphasis.

Conclusions:
The findings show that varying instructions of the effortful swallow affect hyolaryngeal movement differently, suggesting that clinicians may need to individualize the effortful swallow instruction according to the physiological impairments of each patient. Additionally, natural age-related changes in swallowing physiology do not seem to affect an individual's ability to perform the effortful swallow or to impact hyolaryngeal movement. Finally, the association between tongue pressure and hyolaryngeal movement during normal swallows and the effortful swallow with tongue emphasis suggests that the tongue plays a critical role in swallowing, priming subsequent swallowing events.