bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПРОГНОЗУВАННЯ ГОРМОНАЛЬНИХ ПОРУШЕНЬ, ЯКІ ПРИЗВОДЯТЬ ДО НЕСПРИЯТЛИВОГО РЕПРОДУКТИВНОГО ПРОГНОЗУ У ЖІНОК МОЛОДОГО ВІКУ З АВТОІМУННИМ ТИРЕОЇДИТОМ
Authors: Пасєчко Н. В. , Кульчінська В. М. 
Published: July 2023

РЕЗЮМЕ. Умови сучасного суспільства вимагають створення чіткого діагностичного алгоритму, який дозволить швидко та точно виявляти жінок високих груп ризику виникнення та прогресування гормональних порушень на тлі автоімунного тиреоїдиту, які будуть впливати на несприятливий репродуктивний прогноз.
Метою було розробити математичну модель прогнозування гормональних порушень у жінок репродуктивного віку на тлі автоімунного тиреоїдиту, які сприяють негативному репродуктивному прогнозу.
Матеріал і методи. Нами обстежено 147 жінок репродуктивного віку (середній вік (33±1,87) р.) з автоімунним тиреоїдитом. Усім пацієнтам було проведено комплексне клініко-лабораторне обстеження. Для побудови прогностичної моделі гормональних порушень у жінок з автоімунним тиреоїдитом використовували множинний регресійний аналіз. Для статистичної обробки використовували статистичний пакет Statistica 10.0 і табличний редактор Microsoft Excel 2007.
Результати. Було виділено 11 достовірних факторів, до яких увійшли: вік, ТТГ, АТПО, АТТГ, 25(OH)D, АМГ, ЛПНЩ, ЛПВЩ, статус куріння, тривожний і депресивний синдроми, для прогнозування гормональних порушень при автоімунному тиреоїдиті, які сприяють несприятливому репродуктивному прогнозу у молодих жінок, та побудовано математичну модель, гістограму залишкових відхилень та діаграму розсіювання залишків.
Висновки. Розроблена модель прогнозування гормональних порушень при автоімунному тиреоїдиті, які призводять до несприятливого репродуктивного прогнозу, є якісною та інформативною. Використання даної моделі у клінічній практиці дозволить вчасно виділити групу жінок із високим ризиком прогресування гормональних порушень на тлі захворювання, які негативно впливають на репродуктивну здатність.
ВПЛИВ КОМПЛЕКСНОГО ЛІКУВАННЯ НА ПРОГРЕСУВАННЯ ФІБРОЗУ ПЕЧІНКИ У ПАЦІЄНТІВ ПІСЛЯ ПОЛІХІМІОТЕРАПІЇ
Authors: Прокопчук О. В. , Господарський І. Я. 
Published: July 2023

РЕЗЮМЕ. Токсичний вплив лікарських препаратів на організм, зокрема на печінку, часто спостерігається при застосуванні протипухлинних засобів. Незважаючи на це, на сьогоднішній день немає стандартної стратегії лікування для таких уражень, які є одними з найсерйозніших ускладнень поліхіміотерапії [1, 3, 4, 7]. У статті досліджено вплив комплексного лікування на прогресування фіброзу печінки у пацієнтів після поліхіміотерапії.
Мета – дослідити та вивчити можливість комплексного лікування постгепатитного фіброзу печінки в якості медикаментозного її ураження, індукованого цитостатичною терапією з приводу раку молочної залози, в поєднанні з надмірною масою тіла та ожирінням.
Матеріал і методи. У дослідженні взяли участь жінки віком від 35 до 79 років, з фіброзом F1-F2 та різними показниками ІМТ (нормальною масою тіла, передожирінням та ожирінням І ступеня) яких поділили на дві групи – пацієнти І групи отримували немедикаментозну терапію (НМТ), пацієнти ІІ групи – медикаментозну терапію (МТ) (УДХК та вітамін Е). Після закінчення лікування пацієнтам виконано комплекс загальноклінічних лабораторних та інструментальних обстежень з метою порівняння ефекту від призначеної терапії.
Результати. Призначення УДХК у дозі 15 мг/кг на добу і вітаміну Е у дозі 400 МО на добу сприяло зменшенню клінічних проявів хвороби та показників жорсткості печінкової паренхіми за даними еластографії хвилі зсуву (на 17,9 %), нормалізації рівня непрямих показників фіброзу печінки АлАТ, АсАТ, рівня ЗХС, поступовій нормалізації прямих маркерів COL-4 та TGF-β1 за даними динамічного спостереження. Запропонований спосіб оптимізації лікування у значної частини пацієнтів дозволяє не лише зменшити ступінь ехогенності печінки, а й сповільнити темпи її фіброзування.
ГІСТОЛОГІЧНІ ЗМІНИ ПЕЧІНКИ, НИРОК ТА СЕЛЕЗІНКИ ТВАРИН ЗА УМОВИ ВВЕДЕННЯ НАНОЧАСТИНОК ОКСИДУ ЦИНКУ ТА ГЕРБІЦИДУ ГЛІФОСАТУ
Authors: Петренко Я. Ю. , Летняк Н. Я. , Корда М. М. 
Published: July 2023

РЕЗЮМЕ. Одними з найперспективніших видів наноматеріалів є високодисперсні наночастинки оксиду цинку, які все ширше використовуються в біомедицині. Незважаючи на широке застосування, їх безпека для людини досі не з’ясована. Потенційно небезпечною може бути ситуація, коли наночастинки потрапляють в організм разом із хімічними токсинами, наприклад, гербіцидами.
Мета – дослідити інтегральний вплив наночастинок оксиду цинку і гербіциду гліфосату на морфологічну структуру органів тварин.
Матеріал і методи. Білим щурам вводили перорально впродовж 14-и діб 0,5 мл суспензії наночастинок оксиду цинку в дозі 100 мг/кг маси тіла, 0,5 мл розчину гліфосату в дозі 250 мг/кг маси тіла або наночастинки і гліфосат у таких же дозах. На 15-у добу використовували тканини печінки, нирок і селезінки для морфологічних досліджень.
Результати. Введення експериментальним тваринам наночастинок оксиду цинку призводить лише до незначних змін судинного та паренхіматозного компонентів печінки, нирок і селезінки. Застосування гербіциду гліфосату викликає суттєві судинні розлади (розширення і повнокров’я вен, спазмування просвітів міжчасточкових артерій, розширення синусоїдів із явищами тромбозу, потовщення медії, набряк міоцитів, набряк периваскулярної сполучної тканини, повнокров’я гемокапілярів клубочків, стази і сладжі в перитубулярних капілярах) та порушення гістоархітектоніки досліджуваних органів (порушення балкового розміщення гепатоцитів, утрата контурів каріолеми, ознаки вакуольної дистрофії цитоплазми, гіпертрофія ниркових тілець, звуження просвіту капсули, деформація ниркових тілець, гідропічна дистрофія епітеліоцитів проксимальних канальців, набряк та дистрофія нефроцитів, підвищена гідратація основної речовини сполучної тканини, деструктуризація білої пульпи, активна проліферація лімфоцитів). У тварин, яким одночасно вводили токсикант гліфосат та наночастинки оксиду цинку, спостерігаються найвираженіші судинні, запальні та деструктивно-дегенеративні зміни усіх структурних компонентів печінки, нирок і селезінки.
Exploring the Application of the Social Cost of Carbon in Loss-and-Damage and Impact Assessment
Authors: Majekolagbe Adebayo , Seck Sara L. , Wright David V. 
Published: July 2023

Abstract
In this tribute to our friend and colleague, Dr Meinhard Doelle, we bring together three strands of work that we each undertook in collaboration with Meinhard: social cost of carbon, climate change loss and damage, and climate impact assessment. We first introduce social cost of carbon estimates as a form of carbon valuation used in decision-making processes in Canada and the United States. We then introduce legal approaches to climate change loss and damage and related challenges of economic and non-economic valuation. After contemplating the potential for social cost of carbon to contribute to valuation of loss and damage, and vice versa, we examine the integration of climate change in impact assessment law. Ultimately, we tentatively consider whether application of the social cost of carbon for the valuation of loss and damage in impact assessment processes might help to centre justice concerns. In conclusion, we pose questions for future research.
The BiTe_Corpus as a Tool for Data Exploration in the History of Hispanic Linguistics
Authors: Battaner Moro Elena , Herranz-Llácer Cristina V. , Gordillo Ana Segovia 
Published: July 2023

Abstract
Digital humanities make it possible to approach traditional academic topics (such as Hispanic linguistic historiography) from a novel and revelatory perspective. Using tools such as Voyant Tools or Gephi, one can study both primary and secondary sources from the history of linguistics and extract various theoretical and historical values subject to historiographical and meta-historiographical reflection. To that end, combining corpora that facilitate analysis using digital tools is necessary. This article explains the steps that have been followed to create a corpus based on more than 3,000 abstracts gathered in the Bibliografía Temática de Historiografía Lingüística Española: fuentes secundarias [BiTe]. In doing so, researchers have access to a set of data which can be analysed in order to continue advancing in the history of Hispanic linguistics, thus offering a working methodology that can be exported to other traditions and currents in the field of linguistics.
“Merciful Substitution”: A Comparative-Theological Appraisal of George Hunsinger’s Philippians from an Evangelical Reformed Perspective
Authors: Tseng Shao Kai 
Published: July 2023

Abstract
This article consists of a comparative-theological appraisal of George Hunsinger’s Philippians in the Brazos Theological Commentary series. My aim is to bring the author’s constructive proposal of the doctrine of “merciful substitution” into dialogue with the evangelical notion of penal substitution. I will show that Hunsinger is largely in agreement with at least the wing of evangelicalism represented by followers of Geerhardus Vos like Richard Gaffin and G. K. Beale. I will present the case of John Owen and resort to the Canons of Dort to show that in this strain of evangelical theology, penal substitution describes only one aspect of the exchange of righteousness and guilt through participation. What evangelicals can learn from Hunsinger’s commentary, I will argue, is his relentless effort to formulate the doctrine of substitutionary atonement within an explicitly Nicene-Chalcedonian framework.
Optimizing the Biogeochemical Argo Float Distribution
Authors: Chamberlain Paul , Talley Lynne D. , Cornuelle Bruce , Mazloff Matthew , Gille Sarah T. 
Published: July 2023

Abstract
The core Argo array has operated with the design goal of uniform spatial distribution of 3° in latitude and longitude. Recent studies have acknowledged that spatial and temporal scales of variability in some parts of the ocean are not resolved by 3° sampling and have recommended increased core Argo density in the equatorial region, boundary currents, and marginal seas with an integrated vision of other Argo variants. Biogeochemical (BGC) Argo floats currently observe the ocean from a collection of pilot arrays, but recently funded proposals will transition these pilot arrays to a global array. The current BGC Argo implementation plan recommends uniform spatial distribution of BGC Argo floats. For the first time, we estimate the effectiveness of the existing BGC Argo array to resolve the anomaly from the mean using a subset of modeled, full-depth BGC fields. We also study the effectiveness of uniformly distributed BGC Argo arrays with varying float densities at observing the ocean. Then, using previous Argo trajectories, we estimate the Argo array’s future distribution and quantify how well it observes the ocean. Finally, using a novel technique for sequentially identifying the best deployment locations, we suggest the optimal array distribution for BGC Argo floats to minimize objective mapping uncertainty in a subset of BGC fields and to best constrain BGC temporal variability.
Exploring the usability of a smartphone application to monitor fatigue and activity for people with acquired brain injury
Authors: Ezekiel Leisle , Veiga Jose Juan Dominguez , Ward Tomas , Dawes Helen , Collett Johnny 
Published: July 2023

Background: Fatigue after acquired brain injury (ABI) leads to detrimental changes in ABI survivors’ daily activities and participation. There is a need to capture individual’s experience of fatigue as it happens, to better support self-management of fatigue. Study aims: To investigate the usability of a real-time tracker of fatigue and activity (using ecological momentary assessment delivered by a smartphone application) and the feasibility of capturing activity and environmental factors using phone sensors. Methods: Participants wore an activity monitor and completed up to eight surveys a day on a smartphone app, for 6 days, completed the system usability scale (SUS) and were interviewed on their views of using the app. Interview transcripts were analysed using qualitative content analysis. Agreement between data from the phone’s sensors and the activity monitor was analysed using Kappa statistics. Results: Seven participants completed between 11 and 58 surveys. Mean score on the SUS indicated good perceived usability of the app. Phone sensors did not reliably capture physical activity or background noise. Participants found the app easy to use and perceived self-monitoring to help their understanding of fatigue. A fatigue-tracking app may be acceptable to ABI survivors and has potential to aid self-management of fatigue.
Physical activity measurements in individuals with interstitial lung disease: a systematic review and meta-analysis
Authors: Iwakura Masahiro , Kawagoshi Atsuyoshi , Tamaki Akira , Oki Yutaro , Oshima Yohei , Spruit Martijn A 
Published: July 2023

BackgroundPhysical activity (PA) measurements are becoming common in interstitial lung disease (ILD); however, standardisation has not been achieved. We aimed to systematically review PA measurement methods, present PA levels and provide practical recommendations on PA measurement in ILD.MethodsWe searched four databases up to November 2022 for studies assessing PA in ILD. We collected information about the studies and participants, the methods used to measure PA, and the PA metrics. Studies were scored using 12 items regarding PA measurements to evaluate the reporting quality of activity monitor use.ResultsIn 40 of the included studies, PA was measured using various devices or questionnaires with numerous metrics. Of the 33 studies that utilised activity monitors, a median of five out of 12 items were not reported, with the definition of nonwear time being the most frequently omitted. The meta-analyses showed that the pooled means (95% CI) of steps, time spent in moderate to vigorous PA, total energy expenditure and sedentary time were 5215 (4640–5791) steps·day−1, 82 (58–106) min·day−1, 2130 (1847–2412) kcal·day−1and 605 (323–887) min·day−1, respectively, with considerable heterogeneity.ConclusionThe use of activity monitors and questionnaires in ILD lacks consistency. Improvement is required in the reporting quality of PA measurement methods using activity monitors.
SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis
Authors: Kelly J. Daniel , Curteis Tristan , Rawal Aaditya , Murton Molly , Clark Laura J. , Jafry Zarena , Shah-Gupta Rikisha , Berry Mark , Espinueva Aprille , Chen Linda , Abdelghany Mazin , Sweeney Daniel A. , Quint Jennifer K. 
Published: July 2023

BackgroundMany individuals hospitalised with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection experience post-acute sequelae of SARS-CoV-2 infection (PASC), sometimes referred to as “long COVID”. Our objective was to conduct a systematic literature review and meta-analysis to identify PASC-associated symptoms in previously hospitalised patients and determine the frequency and temporal nature of PASC.MethodsSearches of MEDLINE, Embase, Cochrane Library (2019–2021), World Health Organization International Clinical Trials Registry Platform and reference lists were performed from November to December 2021. Articles were assessed by two reviewers against eligibility criteria and a risk of bias tool. Symptom data were synthesised by random effects meta-analyses.ResultsOf 6942 records, 52 studies with at least 100 patients were analysed; ∼70% were Europe-based studies. Most data were from the first wave of the pandemic. PASC symptoms were analysed from 28 days after hospital discharge. At 1–4 months post-acute SARS-CoV-2 infection, the most frequent individual symptoms were fatigue (29.3% (95% CI 20.1–40.6%)) and dyspnoea (19.6% (95% CI 12.8–28.7%)). Many patients experienced at least one symptom at 4–8 months (73.1% (95% CI 44.2–90.3%)) and 8–12 months (75.0% (95% CI 56.4–87.4%)).ConclusionsA wide spectrum of persistent PASC-associated symptoms were reported over the 1-year follow-up period in a significant proportion of participants. Further research is needed to better define PASC duration and determine whether factors such as disease severity, vaccination and treatments have an impact on PASC.
Triage policy to postpone endoscopy for patients with low-risk varices is safe during the lockdown period of COVID-19 pandemic
Authors: Chen Yu-Jen , Hou Ming-Chih , Yang Tsung-Chieh , Lee Pei-Chang , Huang Yi-Hsiang , Lee Fa-Yauh 
Published: July 2023

Abstract
Background & aims
During the COVID-19 pandemic, most of the endoscopic services were electively postponed or suspended. We aimed to assess the safety of a triage policy in patients receiving esophageal variceal ligation during the COVID-19 pandemic.

Methods
Triage policy of endoscopic variceal ligation (EVL) was implemented in our hospital during the lockdown period from 15th May 2021 to 26th July 2021. One experienced gastroenterologist reviewed the prior-scheduled list of patients for the EVL prophylaxisprogram. We compared the clinical characteristics and outcomes with those receiving endoscopy due to esophageal varices from 17th May 2020 to 28th July 2020.

Results
Of the 124 patients receiving EVL, a higher percentage of esophageal variceal bleeding (EVB) was noted (9/32, 28.1% vs. 8/92, 8.7%, p = 0.006) during the lockdown period, with a higher percentage of EVB in the referrals (7/9, 77.8% vs. 2/14, 14.2%, p = 0.007). Among patients who received prophylactic EVL, 6 of 78 (7.7%) experienced EVB during the normal period, which is no different to 2 of 23 (8.7%) during the lockdown period. Twenty-three patients whose endoscopies were postponed by triage policy due to low-risk or eradicated varices did not experience EVB during the lockdown period. Child-Turcotte-Pugh (CTP) class C was predictive of EVB (relative risk 8.400, P = 0.033), entering the program of prophylactic EVL was the protective factor of EVB (relative risk 0.016, P = 0.002).

Conclusion
Entrance into the prophylaxis program does not only decreases risk of EVB but also fosters comprehensive triage to postpone endoscopy during the lockdown period.
Implementing online group model building to unravel complex geriatric problems, a methodological description
Authors: Smeekes Oscar S , Willems Hanna C , Blomberg Ilse , Rouwette Etiënne A J A , Buurman Bianca M 
Published: July 2023

AbstractBackgroundGroup model building (GMB), is a qualitative focus group like study design from the field of system dynamics, that leads a group of topic experts (often key stakeholders of a problem), through a set of scripted activities to create a conceptual model of their shared view on this problems’ key contributing factors and their interactions. By offering a specific step wise approach to the complexity of a problem, GMB has provided better understanding and overview of complex problems across different scientific domains, in addition to traditional research methods. As the development of geriatric syndromes and organization of geriatric care are often complex issues that are difficult to research, understand and resolve, GMB might be a useful methodology to better address these issues. This study aimed to describe the methodology of online GMB using a geriatric case study.MethodsFour online GMB sessions were designed by two clinician researchers. A GMB methodology expert was consulted for optimal design. Scriptapedia scripts formed the core of the sessions. These scripts were adapted to the online format. Experts were recruited purposefully and included seven local health care professionals, one patient representative and one healthcare insurance data analyst. The outcome was a conceptual model of older adults’ emergency department visits, which was discussed in a separate article.ResultsDuring implementation of these four sessions, the sessions were adjusted and two extra (non-scripted) sessions were added because defining unambiguous contributing factors to the geriatric case was challenging for the experts. Paraphrasing, categorizing, iterative plenary reflection, and reserving extra time were used to help experts overcome this challenge. All sessions were held in April and May 2021.ConclusionThis study shows that GMB can help unravel complex problems in geriatrics, both pathophysiological as organizational, by creating step wise overview of their key contributing factors and interactions. Furthermore, it shows that GMB can be used by clinicians, researchers and health policy makers to better understand complex geriatric problems. Moreover, this paper can help to overcome specific implementational challenges in the geriatric field.
New asymptomatic thrombosis caused by carotid web during the acute period of cerebral infarction
Authors: Wang Yan , Li Hai-Lei , Xu Xiao-Hua , Ye Jin-Hao , Li Jian 
Published: July 2023

Abstract
Background
At present, the carotid web (CaW) as an important cause of cryptogenic ischemic stroke has gradually received clinical attention. CaW is associated with a high risk of stroke and patient is more likely to have recurrent stroke if the CaW is untreated. We report a patient who developed CaW related thrombosis during the acute period of cerebral infarction.

Case presentation
A 49-year-old male patient with CaW in the left internal carotid artery was diagnosed by computed tomography angiography (CTA) and had two cerebral infarctions in two years. Within 72 h after thrombolysis for an acute cerebral infarction, acute thrombosis was identified between the web and the posterior wall of the carotid artery on carotid ultrasound. Emergent carotid endarterectomy (CEA) was performed to remove abnormal CaW structures and thrombosis to prevent stroke. The patient recovered well and was asymptomatic at 2 months follow-up.

Conclusion
Carotid web related thromboembolism is a rare cause of stroke. Carotid ultrasound plays an important role in the diagnosis of asymptomatic thrombosis caused by carotid web. Carotid endarterectomy is effective for stroke prevention in patient with carotid web related thrombosis.
Comparison of widefield swept-source optical coherence tomographic angiography and fluorescein fundus angiography for detection of retinal neovascularization with diabetic retinopathy
Authors: Yang Yanyan , Li Fengjiao , Liu Tingting , Jiao Wanzhen , Zhao Bojun 
Published: July 2023

Abstract
Background
To compare vitreous angiomosaic images (VAMIs), obtained by widefield swept-source optical coherence tomographic angiography (wfSS-OCTA) and the image of fluorescein fundus angiography (FFA) in the identification of retinal neovascularization (NV) in patients with diabetic retinopathy (DR).

Methods
In this prospective observational study, severe non-proliferative diabetic retinopathy (NPDR) or proliferative DR (PDR) patients were included. All patients underwent FFA and wfSS-OCTA. The number of NVs identified by wfSS-OCTA VAMIs using five fixations 12 × 12 mm montage scans and the resembling FFA images were compared.

Results
Fifty-three eyes of 29 patients were enrolled. NVs were detected in 25 eyes by using FFA, including 9 NVs of the disc (NVDs) and 72 NVs elsewhere (NVEs), and in 29 eyes by OCTA, including 11 NVDs and 90 NVEs. The detection rate of NV and NVD of OCTA was comparable to that of FFA (p > 0.05), and the level of agreement was excellent (κ = 0.850, κ = 0.754). Using FFA as the gold standard, the sensitivity for detection of NV by OCTA was 100.0%, specificity was 85.7%, the positive-predictive value was 86.2%, and the negative-predictive value was 100.0%. Compared with FFA, OCTA was superior in terms of the number of NVEs identified (p = 0.024). When we excluded images of patients treated with anti-vascular endothelial growth factor (VEGF) intravitreal therapy for < 3 months, OCTA was comparable to FFA in terms of the number of NVEs discovered (p = 0.203), with excellent agreement (intraclass correlation coefficient = 0.941).

Conclusions
WfSS-OCTA is an independent non-invasive alternative to FFA for NV discovery, NVD detection, and individual NVE identification, particularly in patients with PDR who have a history of prior treatment with anti-VEGF.