bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ghana and Nkrumah Revisited: Lenin, State Capitalism, and Black Marxist Orbits
Authors: Osei-Opare Nana 
Published: January 2023

AbstractThis paper reexamines African socialism, the Ghanaian political economy under Kwame Nkrumah (1957–1966), Nkrumah’s intellectual genealogical heritage, and African intellectual history as a genre that transcends the bounds of the Atlantic world. First, I sketch the lives of Black Marxists—Nkrumah, C.L.R. James, George Padmore, and Bankole Awoonor-Renner—from Africa and the Americas, to the Soviet Union, to England and Ghana, to rethink Black bodies not merely as theorists of racial and decolonial questions but also as sites, carriers, and manipulators of political-economic theories. In constructing connected and overlapping histories, I demonstrate how controversial and contested Soviet ideas became key sites of interrogation among global Black Marxists. By reframing travel as an intellectual process, I reconceptualize the movements of Black Marxists to the USSR, the United States, England, and Ghana as critical intellectual and historical processes in their understandings of Lenin’s state capitalist ideas. Second, I revisit the Ghanaian political economy under Nkrumah to argue that combining socialist and capitalist development paths was not a contradictory Marxian policy but was embedded within Black Marxist understandings of Lenin’s state capitalist ideas. In so doing, I argue that we must situate African political ideologies not solely within a romanticized Afrocentric origin but as ideas that emerge out of contemporaneous global political and ideological struggles. I draw on global Black Marxists’ correspondence; newspaper and magazine articles; British and American espionage files; and Ghanaian, American, and British state and inter-state departmental documents in imperial, colonial, and postcolonial British, Ghanaian, American, and Russian archives.
Rethinking Political Agency in the Russian Revolution: A View from the Russian Empire's Borderlands
Authors: Shtakser Inna 
Published: January 2023

AbstractThe four books under review challenge the revolutionary leadership-centered view of the Russian Revolution from various perspectives. Specifically, they highlight the influence on revolutionary politics of seemingly peripheral groups such as workers and Jewish revolutionary activists. Each of the authors claims that the agendas of these groups were considerably more important than the agendas of the revolutionary leadership in ensuring the success or the failure of revolutionary policies.
Review: bioavailability and efficacy of ‘free’ curcuminoids from curcumagalactomannoside (CGM) curcumin formulation
Authors: Matthewman Cristina , Krishnakumar I.M. , Swick Andrew G. 
Published: January 2023

AbstractThe golden spice turmeric with its main bioactive component curcumin is one of the most popular and extensively studied nutraceuticals. Despite numerous pre-clinical studies reporting positive pharmacodynamics of turmeric extracts and curcumin, the main issues in translating the pharmacological effects to clinical efficacy have been to overcome its poor pharmacokinetics and to deliver significant amounts of the biologically relevant forms of the actives to various tissues. This review is aimed at providing a first critical evaluation of the current published literature with the novel curcumagalactomannoside (CGM) formulation of curcumin using fenugreek galactomannan dietary fibre, specifically designed to address curcumin poor pharmacokinetics. We describe CGM and its technology as a food-grade formulation to deliver ‘free’ unconjugated curcuminoids with enhanced bioavailability and improved pharmacokinetic properties. The therapeutic relevance of improving bioavailability of ‘free’ curcuminoids and some of the technical challenges in the measurement of the ‘free’ form of curcuminoids in plasma and tissues are also discussed. A total of twenty-six manuscripts are reviewed here, including fourteen pre-clinical and twelve clinical studies that have investigated CGM pharmacokinetics, safety and efficacy in various animal models and human conditions. Overall current scientific evidence suggests CGM formulation has improved bioavailability and tissue distribution of the biologically relevant unconjugated forms of turmeric actives called ‘free’ curcuminoids that may be responsible for the superior clinical outcomes reported with CGM treatments in comparison with unformulated standard curcumin across multiple studies.
Immediate results of primary balloon dilation for congenital aortic valve stenosis predict the mid-term outcome
Authors: Pavlovic Andrija , Parezanovic Vojislav , Stefanovic Igor , Dähnert Ingo , Tzifa Aphrodite , Djordjevic Stefan A. , Ilic Slobodan , Milovanovic Vladimir , Bijelic Maja , Bisenic Dejan , Kalanj Jasna , Djukic Milan 
Published: January 2023

AbstractBackground:Balloon valvuloplasty is the primary treatment for congenital aortic valve stenosis in our centre. We sought to determine independent predictors of reintervention (surgical repair or repeated balloon dilation) after primary valvuloplasty.Methods:We retrospectively studied patients with congenital aortic valve stenosis who underwent balloon valvuloplasty during 2004–2018. The following risk factors were analysed: aortic valve insufficiency after balloon valvuloplasty >+1/4, post-procedural gradient across the aortic valve ≥35 mmHg, pre-interventional gradient across the valve, annulus size, use of rapid pacing, and balloon/annulus ratio. Primary outcome was aortic valve reintervention.Results:In total, 99 patients (median age 4 years, range 1 day to 26 years) underwent balloon valvuloplasty for congenital aortic valve stenosis. After a mean follow-up of 4.0 years, 30% had reintervention. Adjusted risks for reintervention were significantly increased in patients with post-procedural aortic insufficiency grade >+1/4 and/or residual gradient ≥35 mmHg (HR 2.55, 95% CI 1.13–5.75, p = 0.024). Pre-interventional gradient, annulus size, rapid pacing, and balloon/annulus ratio were not associated with outcome.Conclusion:Post-procedural aortic valve insufficiency grade >+1/4 and/or residual gradient ≥35 mmHg in patients undergoing balloon valvuloplasty for congenital aortic valve stenosis confers an increased risk for reintervention in mid-term follow-up.
The impact of SNAP-Ed interventions on California students’ diet and physical activity during COVID-19
Authors: Linares Amanda , Plank Kaela , Hewawitharana Sridharshi C , Woodward-Lopez Gail 
Published: January 2023

AbstractObjective:School-based CalFresh Healthy Living (CFHL) (California’s SNAP-Ed) interventions adapted to new learning environments necessitated by COVID-19. We examined the impact of these interventions on student diet and physical activity (PA) outcomes.Design:Quasi-experimental, two-group, pre-post.Setting:California public schools with ≥50 % of students Free and Reduced Price Meal-eligible (nintervention= 47;ncomparison= 17).Participants:Fourth- and fifth-grade students who completed the online Eating and Activity Tool for Students at pre and post (nintervention= 1087;ncomparison= 846 students).Results:Intervention students reported a significantly greater increase in consumption frequency of total fruit (by 0·16 times/d;P= 0·032), driven primarily by a greater increase in 100 % fruit juice (by 0·11 times/d;P= 0·007). Intervention students reported a significantly greater increase in total vegetable consumption frequency (by 0·45 times/d;P< 0·001) than comparison students. Specifically, intervention students reported increased, whereas comparison students reported decreased, consumption frequencies for starchy vegetables (0·05v. −0·10 times/d,P< 0·001), salad/green vegetables (0·01v. −0·11 times/d,P= 0·005) and beans (0·04v. −0·03 times/d,P= 0·025). Consumption frequency of other vegetables decreased in both groups (−0·01v. −0·09 times/d) but decreased more among comparison students (P= 0·048). No differences in pre-post change in PA outcomes were detected.Conclusions:Findings suggest that despite COVID-19-related challenges necessitating programme modifications, CFHL interventions played a role in protecting student consumption of fruit and vegetables during the 2020–2021 school year. Therefore, it appears that school-based CFHL interventions can be a viable means of safeguarding student nutrition at a time when access to nutritious food and PA opportunities are hindered.
Multiple Group Membership, Optimistic Bias, and Infection Risk in the	Context of Emerging Infectious Diseases
Authors: Frings Daniel , Wills Jane , Sykes Susie , Wood Kerry V. , Albery Ian P. 
Published: January 2023

Abstract: Background: Understanding psychosocial factors which impact responses to emerging infectious diseases (EIDs) is vital in managing epidemics and pandemics. Two under-researched areas in this field are the interactive roles of optimistic bias (underestimation of the likelihood of negative events occurring to the self, relative to others) and group membership (a factor observed to be psychologically protective, but infection risk enhancing). Aims: The current study aimed to test the relationships between optimistic bias and membership of multiple groups upon EID-related emotional and psychological responses and behavioral intentions. Methods: Participants from the UK and US ( N = 360) rated how they would evaluate and respond to a fictitious EID immediately before the 2020 COVID-19 lockdowns in a correlational study. Results: Negative relationships were observed between optimistic bias and perceived infection vulnerability, infection prevention strategies, and perceived EID severity. Multiple group membership correlated negatively with germ avoidance, but positively with emotional responses such as disgust and increased perceived vulnerability to infection – factors linked to avoiding infection. Multiple group memberships and optimistic bias were unrelated. Limitations: The study focussed on a fictitious disease and relies on cross-sectional data and behavioral intentions. Conclusions: These findings build upon the small evidence base on the role of optimistic bias in EID management and suggest that multiple group membership is unlikely to increase optimistic bias. The theoretical and practical implications of the findings for EID management are discussed.
Effect of Plankton Composition Shifts in the North Atlantic on Atmospheric pCO2
Authors: Boot A. , von der Heydt A. S. , Dijkstra H. A. 
Published: January 2023

AbstractMarine carbon cycle processes are important for taking up atmospheric CO2 thereby reducing climate change. Net primary and export production are important pathways of carbon from the surface to the deep ocean where it is stored for millennia. Climate change can interact with marine ecosystems via changes in the ocean stratification and ocean circulation. In this study we use results from the Community Earth System Model version 2 (CESM2) to assess the effect of a changing climate on biological production and phytoplankton composition in the high latitude North Atlantic Ocean. We find a shift in phytoplankton type dominance from diatoms to small phytoplankton which reduces net primary and export productivity. Using a conceptual carbon‐cycle model forced with CESM2 results, we give a rough estimate of a positive phytoplankton composition‐atmospheric CO2 feedback of approximately 60 GtCO2/°C warming in the North Atlantic which lowers the 1.5° and 2.0°C warming safe carbon budgets.
Fast Spin‐Up of Geochemical Tracers in Ocean Circulation and Climate Models
Authors: Khatiwala Samar 
Published: January 2023

AbstractOcean geochemical tracers such as radiocarbon, protactinium and thorium isotopes, and noble gases are widely used to constrain a range of physical and biogeochemical processes in the ocean. However, their routine simulation in global ocean circulation and climate models is hindered by the computational expense of integrating them to a steady state. Here, a new approach to this long‐standing “spin‐up” problem is introduced to efficiently compute equilibrium distributions of such tracers in seasonally‐forced models. Based on “Anderson Acceleration,” a sequence acceleration technique developed in the 1960s to solve nonlinear integral equations, the new method is entirely “black box” and offers significant speed‐up over conventional direct time integration. Moreover, it requires no preconditioning, ensures tracer conservation and is fully consistent with the numerical time‐stepping scheme of the underlying model. It thus circumvents some of the drawbacks of other schemes such as matrix‐free Newton Krylov that have been proposed to address this problem. An implementation specifically tailored for the batch HPC systems on which ocean and climate models are typically run is described, and the method illustrated by applying it to a variety of geochemical tracer problems. The new method, which provides speed‐ups by over an order of magnitude, should make simulations of such tracers more feasible and enable their inclusion in climate change assessments such as IPCC.
Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia
Authors: Ryan Sarra L. , Peden John F. , Kingsbury Zoya , Schwab Claire J. , James Terena , Polonen Petri , Mijuskovic Martina , Becq Jenn , Yim Richard , Cranston Ruth E. , Hedges Dale J. , Roberts Kathryn G. , Mullighan Charles G. , Vora Ajay , Russell Lisa J. , Bain Robert , Moorman Anthony V. , Bentley David R. , Harrison Christine J. , Ross Mark T. 
Published: January 2023

AbstractChildhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent genetic abnormalities that drive risk-directed treatment strategies. Using current techniques, accurate detection of such aberrations can be challenging, due to the rapidly expanding list of key genetic abnormalities. Whole genome sequencing (WGS) has the potential to improve genetic testing, but requires comprehensive validation. We performed WGS on 210 childhood B-ALL samples annotated with clinical and genetic data. We devised a molecular classification system to subtype these patients based on identification of key genetic changes in tumour-normal and tumour-only analyses. This approach detected 294 subtype-defining genetic abnormalities in 96% (202/210) patients. Novel genetic variants, including fusions involving genes in the MAP kinase pathway, were identified. WGS results were concordant with standard-of-care methods and whole transcriptome sequencing (WTS). We expanded the catalogue of genetic profiles that reliably classify PAX5alt and ETV6::RUNX1-like subtypes. Our novel bioinformatic pipeline improved detection of DUX4 rearrangements (DUX4-r): a good-risk B-ALL subtype with high survival rates. Overall, we have validated that WGS provides a standalone, reliable genetic test to detect all subtype-defining genetic abnormalities in B-ALL, accurately classifying patients for the risk-directed treatment stratification, while simultaneously performing as a research tool to identify novel disease biomarkers.
Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells
Authors: Toledano Shira , Sabag Adi D. , Ilan Neta , Liburkin-Dan Tanya , Kessler Ofra , Neufeld Gera 
Published: January 2023

AbstractThe semaphorin guidance factors receptor plexin-A2 transduces sema6A and sema6B signals and may mediate, along with plexin-A4, the anti-angiogenic effects of sema6A. When associated with neuropilins plexin-A2 also transduces the anti-angiogenic signals of sema3B. Here we show that inhibition of plexin-A2 expression in glioblastoma derived cells that express wild type p53 such as U87MG and A172 cells, or in primary human endothelial cells, strongly inhibits cell proliferation. Inhibition of plexin-A2 expression in U87MG cells also results in strong inhibition of their tumor forming ability. Knock-out of the plexin-A2 gene in U87MG cells using CRISPR/Cas9 inhibits cell proliferation which is rescued following plexin-A2 re-expression, or expression of a truncated plexin-A2 lacking its extracellular domain. Inhibition of plexin-A2 expression results in cell cycle arrest at the G2/M stage, and is accompanied by changes in cytoskeletal organization, cell flattening, and enhanced expression of senescence associated β-galactosidase. It is also associated with reduced AKT phosphorylation and enhanced phosphorylation of p38MAPK. We find that the pro-proliferative effects of plexin-A2 are mediated by FARP2 and FYN and by the GTPase activating (GAP) domain located in the intracellular domain of plexin-A2. Point mutations in these locations inhibit the rescue of cell proliferation upon re-expression of the mutated intracellular domain in the knock-out cells. In contrast re-expression of a plexin-A2 cDNA containing a point mutation in the semaphorin binding domain failed to inhibit the rescue. Our results suggest that plexin-A2 may represent a novel target for the development of anti-tumorigenic therapeutics.
Increased endogenous PKG I activity attenuates EGF-induced proliferation and migration of epithelial ovarian cancer via the MAPK/ERK pathway
Authors: Lan Ting , Li Ying , Wang Yue , Wang Zhong-Cheng , Mu Chun-Yan , Tao Ai-Bin , Gong Jian-Li , Zhou Yuan , Xu Hao , Li Shi-Bao , Gu Bing , Ma Ping , Luo Lan 
Published: January 2023

AbstractThe type I cGMP-dependent protein kinase (PKG I) is recognized as a tumor suppressor, but its role in EGFR regulated epithelial ovarian cancer (EOC) progression remains unclear. We evaluated the in vivo and in vitro effects of activated PKG I in EGF-induced EOC cell proliferation, migration, and invasion. The expressions of EGFR and PKG I were elevated, but the activated PKG I was decreased in EOC tissues of patients and cells lines. The addition of 8-Br-cGMP, a specific PKG I activator, attenuated the EGF-induced EOC cell proliferation, migration, and invasion in vitro. Similarly, activated PKG I also attenuated EOC progression in vivo using an EOC xenograft nude mouse model. The activated PKG I interacted with EGFR, causing increased threonine (693) phosphorylation and decreased tyrosine (1068) phosphorylation of EGFR, which resulted in disrupted EGFR-SOS1-Grb2 combination. Subsequently, the cytoplasmic phosphorylation of downstream proteins (c-Raf, MEK1/2, and ERK1/2) were declined, impeding the phosphorylated ERK1/2’s nucleus translocation, and this reduction of phosphorylated tyrosine (1068) EGFR and ERK1/2 were also abolished by Rp-8-Br-cGMPS. Our results suggest that the activation of PKG I attenuates EGF-induced EOC progression, and the 8-Br-cGMP-PKG I-EGFR/MEK/ERK axis might be a potential target for EOC therapy.
Hepatocyte growth factor-mediated apoptosis mechanisms of cytotoxic CD8+ T cells in normal and cirrhotic livers
Authors: Chen Quanyu , Yan Min , Lin Heng , Lai Jiejuan , Yang Zhiqing , Hu Deyu , Deng Yuanyu , Shi Saiyu , Shuai Ling , Zhang Leida , Zhang Hongyu , Bai Lianhua 
Published: January 2023

AbstractIntrahepatic stem/progenitor cells and cytotoxic CD8+ T cells (CD8+ T cells) in the cirrhotic liver undergo apoptosis, which potentially facilitates progression to cancer. Here, we report that hepatocyte growth factor (HGF) signaling plays an important role in promoting normal and damaged liver CD8+ T cell Fas-mediated apoptosis through its only receptor, c-Met. In addition to binding with HGF, c-Met also binds to Fas to form a complex. Using a diethylnitrosamine (DEN)-induced liver fibrosis/cirrhosis mouse model, immunostaining, and terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) staining, we found that HGF secretion was significantly higher at 10 weeks post-DEN, the liver cirrhotic phase (LCP), than at 3 weeks post-DEN, the liver fibrotic phase (LFP). Correspondingly, differences in CD8+ T cell proliferation and apoptosis were noted between the two phases. Interestingly, staining and TUNEL assays revealed lower smooth muscle actin (α-SMA)+ cell apoptosis, a marker for hepatic stellate cells (HSCs), in the LFP group than in the LCP group, which suggested a beneficial correlation among HGF, CD8+ T cells and HSCs in improving the fibrotic load during damaged liver repair. In cultures, when met different concentrations of recombinant HGF (rHGF), phytohemagglutinin (PHA)-stimulated naive mouse splenic CD8+ T cells (pn-msCD8+ T cells) responded differently; as increases in rHGF increased were associated with decreases in the clonal numbers of pn-msCD8+ T cells, and when the rHGF dose was greater than 200 ng/mL, the clonal numbers significantly decreased. In the presence of 400 ng/mL rHGF, the death-inducing signaling complex (DISC) can be directly activated in both nsCD8+ T cells and healthy human peripheral blood CD8+ T cells (hp-CD8+ T cells), as indicated by recruitment of FADD and caspase-8 because DISC forms via the recruitment of FADD and caspase-8, among others. These findings suggest that Fas-mediated apoptosis, may also indicate a regulatory role of HGF signaling in hepatic homeostasis.
Relationship between clinical parameters and quality of life in primary Sjögren’s Syndrome: a prospective study
Authors: Greenan E. , Pilson Q. , Ní Gabhann-Dromgoole J. , Murphy C. C. 
Published: January 2023

Abstract
Objectives
To quantify the impact of dry eye disease (DED) on health and vision related quality of life (HR-QOL, VR-QOL) in patients with Primary Sjögren’s Syndrome (pSS).

Methods
Thirty-four participants with a confirmed diagnosis of pSS as per the 2016 ACR EULAR criteria participated. Main outcome measures included ocular surface parameters and HR-QOL and VR-QOL questionnaires. Clinical examination included visual acuity, Schirmer I testing, ocular surface staining (OSS) and measurement of tear film breakup time. The questionnaires included Ocular Surface Disease Index, National Eye Institute Visual Function Questionnaire-25, Short Form-36 (SF-36) and EULAR Sjogren’s Syndrome Patient Reported Index.

Results
Despite the majority of participants (28 female, 6 male, mean age 61.3 years) having attained LogMAR 0.3 or better visual acuity, participants scored low on VR-QOL measures, representing DED related fluctuation in functional vision. All participants suffered from moderate to severe DED. OSS did not correlate with DED symptoms or QOL parameters. Lubricant usage and symptom severity had a statistically moderate to strong negative correlation with VR-QOL and HR-QOL. This was most evident in relation to physical and physiological wellbeing. Compared with normative data, participants had a lower HR-QOL in all scales of the SF-36 ((MD = 9.91 ± 5.16); t(7) = 5.43, p = 0.001).

Conclusions
Participants with pSS have a lower perceived QOL especially in relation to physical and mental wellbeing, correlating to severity of DED symptoms and treatment burden. Clinical signs do not align with symptoms. Therefore, clinicians should remain cognisant, adjusting treatment in accordance with patient reported perceptions.