bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on high-quality development marketing of scenic spots in the post epidemic era
Authors: Zhang Rong 
Published: April 2023

Under the influence of the epidemic, the number of tourists and the overall income of the Gulongshan Grand Canyon has been greatly reduced, which also highlights the problem that the Gulongshan Grand Canyon is susceptible to external factors due to its sensitivity and vulnerability. Two years after the start of the epidemic, it was not able to resume development. In the late stage of the epidemic, the domestic epidemic entered a state of steady development, but there were still cases of infection rebounding.
At the same time, the overseas epidemic has spread widely and entered a state of high incidence of cases. The Guangxi Gulongshan tourism market itself has not fully recovered, and the development of the overseas tourism market has been restricted, making the recovery of the Gulongshan Grand Canyon even more difficult. The traditional development is also severely limited, so we will use the 4P and swot theory to analyze the current situation of the Gulongshan Grand Canyon, and at the same time refer to the literature review at home and abroad, correctly view the challenges brought by these epidemics, seize the emerging opportunities, and discuss The strategy for the recovery and development of the Gulongshan Grand Canyon after the outbreak of the epidemic will promote the innovation and sustainable development of the Gulongshan Grand Canyon. This topic includes the following aspects: one is to analyze the current situation of the impact of the epidemic on the Gulongshan Grand Canyon scenic spot; the second is the opportunities and challenges faced by the Gulongshan Grand Canyon in the post-epidemic era; the third is the countermeasures and suggestions for the marketing of the Gulongshan Grand Canyon in the post-epidemic era. This paper completes the writing of this topic from these three aspects.
Yalnızlık Damgası Ölçeği: Türkçe geçerlik ve güvenirlik çalışması
Authors: ŞENAY Nilay , BİLGE Yıldız 
Published: April 2023

Bu çalışmanın amacı Yalnızlık Damgası Ölçeği’nin (YDÖ) Türkçe’ye uyarlama ve geçerlik
güvenirlik çalışmasının yapılmasıdır. Çalışma örnekleminin yaş aralığı 18 ile 57 (21.79±3.60) olan 285
(%59) kadın, 196 (%40.6) erkek ve 2 (%0.4) diğer olmak üzere toplam 483 üniversite öğrencisinden
oluşmuştur. Psikoloji bölümü öğrencisi olan 33 kişilik bir katılımcı grubuna 3 hafta arayla test-tekrar
test uygulaması yapılmıştır. Ölçüt geçerliliği kapsamında 239 katılımcıya YDÖ ile birlikte UCLA
Yalnızlık Ölçeği, Depresyon-Anksiyete-Stres Ölçeği (DASS-21), Kısa Psikolojik Sağlamlık Ölçeği
(KPSÖ) uygulanmıştır. Ölçeğin faktör yapısını belirlemek amacıyla açımlayıcı ve doğrulayıcı faktör
analizleri (AFA ve DFA) yapılmış, varimax döndürme yönteminin kullanıldığı AFA’da orijinal
çalışmada olduğu gibi özdeğeri 1’in üzerinde olan iki boyutlu bir yapının oluştuğu saptanmıştır. DFA
sonucunda ise iki faktörlü yapının herhangi bir modifikasyon yapılmadan doğrulandığı ve uyum
indekslerinin kabul edilebilir bir düzeyde olduğu görülmüştür. Ölçek güvenirliği kapsamında YDÖ’nün
Cronbach alfa iç tutarlılık katsayısı hesaplanmış, toplam ölçek için Cronbach alfa katsayısı .91, alt
boyutlar için ise Cronbach alfa iç tutarlılık katsayıları .80 ve .91 olarak tespit edilmiştir. Ölçeğin testtekrar test korelasyon katsayısı toplam ölçek için r=.47, öz-damgalama için r=.58 ve sosyal damgalama
için r=.45 olarak bulunmuştur. YDÖ’nün ölçüt geçerliği için yapılan korelasyon analizleri sonucunda
anlamlı ilişkiler saptanmıştır. Sonuçlar ölçeğin Türkçe versiyonunun geçerli ve güvenilir olduğunu
göstermiştir.
Antimicrobial Susceptibility Pattern of Klebsiella pneumoniae Isolated from Various Clinical Specimens in Ujjain City, Madhya Pradesh, India
Authors: Maity Soumendra N. , Marothi Yogyata , Pradhan Riddhi , Waske Sonali , Hemwani Kirti 
Published: April 2023

Klebsiella pneumoniae is an important opportunistic pathogen that commonly causes nosocomial infections and contributes to substantial morbidity and mortality. We sought to investigate the sensitivity pattern of K. pneumoniae isolated from various clinical specimens. Methods- This cross-sectional study was conducted at Ruxmaniben Deepchand Gardi Medical College and Ujjain Charitable Trust Hospital in Ujjain City during March 2021 to September 2021 on total 463culture positive isolates from various clinical specimens. Identification of K. pneumoniae and antibiogram testing were performed by using VITEK-2 compact bacterial identification and monitoring system (bioMerieux, US). The data were analyzed by using NCSS statistical software 2021. Results- In total, 83 positive K. pneumoniae cultures from various clinical samples were examined. The isolates were more predominant in the females (n = 45; 54.2%) compared to males (n = 38; 45.8%). The antibiotic resistance rate of K. pneumoniae varied among different isolate clinical sample sources. Overall, high resistance rates were recorded for ampicillin (100%), amoxyclav (81.48%), piperacillin/ tazobactam (73.68%), cefuroxime (94.74%), ceftriaxone (91.2%), cefotaxime (91.2%), and cefepime (73.68%). A total of 83 K. pneumoniae isolates, 75 were ESBL (90.36%) producers. However, colistin (100%) showed the highest susceptibility rate against the isolates. Conclusion- the wide variety of MDR K. pneumoniae harboring β-lactams and virulence genes strongly suggest a necessity for the implementation of effective strategies to prevent and control the spread of antibiotic resistant infections.
ANALISIS PENGARUH PERCEIVED VALUE TERHADAP LOYALITAS PELANGGAN DENGAN KEPUASAN KONSUMEN SEBAGAI VARIABEL INTERVENING DITINJAU DARI MANAJEMEN BISNIS SYARIAH (Studi Pada Pengguna Scarlet di Bandar Lampung)
Authors: Yulistia Devi  , Saefurrohman Ghina Ulfah , Ermawati Liya , Ningsih Nurwahyu 
Published: April 2023

Produk skincare yang ada di Indonesia, Scarlet berada pada posisi pertama dengan pangsa pasar yang diraih jauh lebih tinggi dari merek lain, yaitu 18.9%. Nilai persepsi (perceived value) yang tinggi akan menghasilkan kepuasan pelanggan yang tinggi. Sebagaimana diketahui bahwa tujuan dari suatu bisnis adalah untuk menciptakan para pelanggan merasa puas. Terciptanya kepuasaan dapat memberikan beberapa manfaat, diantaranya hubungan antara perusahaan dengan pelanggannya menjadi harmonis sehingga memberikan dasar yang baik bagi pembelian ulang. Penelitian ini menggunakan analisis data kuantitatif. Pemilihan sampel menggunakan teknik probability sampling dengan total sampel berjumlah 100 sampel. Data diolah menggunakan alat bantu program IBM SPSS versi 25. Uji analisis data yang digunakan yaitu uji instrument penelitian (validitas dan reliabilitas), uji asumsi klasik (Normalitas, multikolinearitas, dan heteroskedastisitas), uji t, uji f, dan uji sobel test. Pengujian hipotesis penelitian dilakukan dengan menggunakan model analisis jalur (path analysis). Hasil penelitian menunjukan bahwa : (1) perceived value memiliki pengaruh yang signifikan terhadap loyalitas. (2) perceived value mempunyai pengaruh yang signifikan terhadap kepuasan pelanggan. (3) kepuasan mempunyai pengaruh dan signifikan terhadap Loyalitas pelanggan . (4) Kepuasan konsumen memediasi hubungan antara perceived value terhadap loyalitas konsumen pada pengguna scarlet.
Pengaruh Pengangguran dan Pertumbuhan Ekonomi Terhadap Indeks Pembangunan Manusia
Authors: Susilowati Dados , Adianita Happy 
Published: April 2023

This study aims to determine the effect of unemployment and economic growth on the Human Development Index in Bojonegoro. The research design used is associative descriptive quantitative. The data source for this research is secondary data in the form of data tables for 2006 – 2020 obtained from the Bojonegoro Central Bureau of Statistics (BPS). The technique of determining the sample using the judgment sampling method. The study shows that the variables of unemployment and economic growth simultaneously have a positive and significant influence on the Human Development Index. While partially, the unemployment variable has a negative and insignificant effect and the economic growth variable has a positive and significant influence on the Human Development Index. From the results of the two independent variables, the variable economic growth is the most dominant variable influencing the Bojonegoro Regency Human Development Index with the largest regression coefficient value.
Penelitian ini membahas mengenai pengaruh Pengangguran dan Pertumbuhan Ekonomi terhadap Indeks Pembangunan Manusia kabupaten Bojonegoro tahun 2006-2020. Tingkat pengangguran Kabupaten Bojonegoro selalu mengalami fluktuasi dari tahun ke tahun. Terhitung dari tahun 2006 sampai dengan 2020 tingkat pengangguran Kabupaten Bojonegoro tertinggi terdapat pada tahun 2006 sebesar 10,02%. Dampak buruk yang dapat ditimbulkan oleh pengangguran yaitu berkurangnya pendapatan dalam masyarakat. Pengangguran dan Pertumbuhan ekonomi secara bersama – sama mempengaruhi Indeks Pembangunan Manusia Kabupaten Bojonegoro tahun 2006-2020. Variabel bebas yaitu Pengangguran dan Pertumbuhan Ekonomi hanya mampu mempengaruhi variabel terikat yaitu Indeks Pembangunan Manusia Kabupaten Bojonegoro sebesar 50,51% sedangkan sisanya 49,49% dipengaruhi variabel diluar penelitian. Berdasarkan hasil regresi dapat dijelaskan bahwa variabel Pertumbuhan Ekonomi merupakan variabel dominan dalam mempengaruhi Indeks Pembangunan Manusia Kabupaten Bojonegoro tahun 2006-2020. Hal tersebut sesuai dengan hipotesis penelitian yang menyatakan Pertumbuhan Ekonomi berpengaruh dominan terhadap Indeks Pembangunan Manusia Kabupaten Bojonegoro tahun 2006-2020.
Thermophobic Trehalose Glycopolymers as Smart C‐Type Lectin Receptor Vaccine Adjuvants
Authors: Hendricksen Aaron T. , Ezzatpour Shahrzad , Pulukuri Anunay J. , Ryan Austin T. , Flanagan Tatum J. , Frantz William , Buchholz David W. , Ortega Victoria , Monreal Isaac A. , Sahler Julie M. , Nielsen Amy E. , Aguilar Hector C. , Mancini Rock J. 
Published: April 2023

AbstractHerein, this work reports the first synthetic vaccine adjuvants that attenuate potency in response to small, 1–2 °C changes in temperature about their lower critical solution temperature (LCST). Adjuvant additives significantly increase vaccine efficacy. However, adjuvants also cause inflammatory side effects, such as pyrexia, which currently limits their use. To address this, a thermophobic vaccine adjuvant engineered to attenuate potency at temperatures correlating to pyrexia is created. Thermophobic adjuvants are synthesized by combining a rationally designed trehalose glycolipid vaccine adjuvant with thermoresponsive poly‐N‐isoporpylacrylamide (NIPAM) via reversible addition fragmentation chain transfer (RAFT) polymerization. The resulting thermophobic adjuvants exhibit LCSTs near 37 °C, and self‐assembled into nanoparticles with temperature‐dependent sizes (90–270 nm). Thermophobic adjuvants activate HEK‐mMINCLE and other innate immune cell lines as well as primary mouse bone marrow derived dendritic cells (BMDCs) and bone marrow derived macrophages (BMDMs). Inflammatory cytokine production is attenuated under conditions mimicking pyrexia (above the LCST) relative to homeostasis (37 °C) or below the LCST. This thermophobic behavior correlated with decreased adjuvant Rg is observed by DLS, as well as glycolipid‐NIPAM shielding interactions are observed by NOESY‐NMR. In vivo, thermophobic adjuvants enhance efficacy of a whole inactivated influenza A/California/04/2009 virus vaccine, by increasing neutralizing antibody titers and CD4+/44+/62L+ lung and lymph node central memory T cells, as well as providing better protection from morbidity after viral challenge relative to unadjuvanted control vaccine. Together, these results demonstrate the first adjuvants with potency regulated by temperature. This work envisions that with further investigation, this approach can enhance vaccine efficacy while maintaining safety.
Antisense Oligonucleotides Selectively Enter Human‐Derived Antibiotic‐Resistant Bacteria through Bacterial‐Specific ATP‐Binding Cassette Sugar Transporter
Authors: Liu Mingzhu , Chu Binbin , Sun Rong , Ding Jiali , Ye Han , Yang Yunmin , Wu Yuqi , Shi Haoliang , Song Bin , He Yao , Wang Houyu , Hong Jiaxu 
Published: April 2023

AbstractCurrent vehicles used to deliver antisense oligonucleotides (ASOs) cannot distinguish between bacterial and mammalian cells, greatly hindering the preclinical or clinical treatment of bacterial infections, especially those caused by antibiotic‐resistant bacteria. Herein, bacteria‐specific ATP‐binding cassette (ABC) sugar transporters are leveraged to selectively internalize ASOs by hitchhiking them on α (1–4)‐glucosidically linked glucose polymers. Compared with their cell‐penetrating peptide counterparts, which are non‐specifically engulfed by mammalian and bacterial cells, the presented therapeutics consisting of glucose polymer and antisense peptide nucleic‐acid‐modified nanoparticles are selectively internalized into the human‐derived multidrug‐resistant Escherichia coli and methicillin‐resistant Staphylococcus aureus, and they display a much higher uptake rate (i.e., 51.6%). The developed strategy allows specific and efficient killing of nearly 100% of the antibiotic‐resistant bacteria. Its significant curative efficacy against bacterial keratitis and endophthalmitis is also shown. This strategy will expand the focus of antisense technology to include bacterial cells other than mammalian cells.
DARPP‐32 cells and neuropil define striosomal system and isolated matrix cells in human striatum
Authors: Arasaratnam Christine J. , Song Jennifer J. , Yoshida Tomoko , Curtis Maurice A. , Graybiel Ann M. , Faull Richard L. M. , Waldvogel Henry J. 
Published: April 2023

AbstractThe dorsal striatum forms a central node of the basal ganglia interconnecting the neocortex and thalamus with circuits modulating mood and movement. Striatal projection neurons (SPNs) include relatively intermixed populations expressing D1‐type or D2‐type dopamine receptors (dSPNs and iSPNs) that give rise to the direct (D1) and indirect (D2) output systems of the basal ganglia. Overlaid on this organization is a compartmental organization, in which a labyrinthine system of striosomes made up of sequestered SPNs is embedded within the larger striatal matrix. Striosomal SPNs also include D1‐SPNs and D2‐SPNs, but they can be distinguished from matrix SPNs by many neurochemical markers. In the rodent striatum the key signaling molecule, DARPP‐32, is a exception to these compartmental expression patterns, thought to befit its functions through opposite actions in both D1‐ and D2‐expressing SPNs. We demonstrate here, however, that in the dorsal human striatum, DARPP‐32 is concentrated in the neuropil and SPNs of striosomes, especially in the caudate nucleus and dorsomedial putamen, relative to the matrix neuropil in these regions. The generally DARPP‐32‐poor matrix contains scattered DARPP‐32‐positive cells. DARPP‐32 cell bodies in both compartments proved negative for conventional intraneuronal markers. These findings raise the potential for specialized DARPP‐32 expression in the human striosomal system and in a set of DARPP‐32‐positive neurons in the matrix. If DARPP‐32 immunohistochemical positivity predicts differential functional DARPP‐32 activity, then the distributions demonstrated here could render striosomes and dispersed matrix cells susceptible to differential signaling through cAMP and other signaling systems in health and disease.

DARPP‐32 is highly concentrated in cells and neuropil of striosomes in post‐mortem human brain tissue, particularly in the dorsal caudate nucleus.
Scattered DARPP‐32‐positive cells are found in the human striatal matrix.
Calbindin and DARPP‐32 do not colocalize within every spiny projection neuron in the dorsal human caudate nucleus.
How does solid‐state drives cluster perform for distributed file systems: An empirical study
Authors: Wu Jiashu , Wang Yang , Wang Jinpeng , Wang Hekang , Lin Taorui 
Published: April 2023

SummaryAs the capacity of Solid‐State Drives (SSDs) is constantly being optimised and boosted with gradually reduced cost, the SSD cluster is now widely deployed as part of the hybrid storage system in various scenarios such as cloud computing and big data processing. However, despite its rapid developments, the performance of the SSD cluster remains largely under‐investigated, leaving its sub‐optimal applications in reality. To address this issue, in this paper we conduct extensive empirical studies for a comprehensive understanding of the SSD cluster in diverse settings. To this end, we configure a real SSD cluster and gather the generated trace data based on some often‐used benchmarks, then adopt analytical methods to analyse the performance of the SSD cluster with different configurations. In particular, regression models are built to provide better performance predictability under broader configurations, and the correlations between influential factors and performance metrics with respect to different numbers of nodes are investigated, which reveal the high scalability of the SSD cluster. Additionally, the cluster's network bandwidth is inspected to explain the performance bottleneck. Finally, the knowledge gained is summarised to benefit the SSD cluster deployment in practice.
Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish
Authors: LeBleu Valerie S. , Dai Jianli , Tsutakawa Susan , MacDonald Brian A. , Alge Joseph L. , Sund Malin , Xie Liang , Sugimoto Hikaru , Tainer John , Zon Leonard I. , Kalluri Raghu 
Published: April 2023

AbstractBackgroundType IV collagen is an abundant component of basement membranes in all multicellular species and is essential for the extracellular scaffold supporting tissue architecture and function. Lower organisms typically have two type IV collagen genes, encoding α1 and α2 chains, in contrast with the six genes in humans, encoding α1–α6 chains. The α chains assemble into trimeric protomers, the building blocks of the type IV collagen network. The detailed evolutionary conservation of type IV collagen network remains to be studied.ResultsWe report on the molecular evolution of type IV collagen genes. The zebrafish α4 non‐collagenous (NC1) domain, in contrast with its human ortholog, contains an additional cysteine residue and lacks the M93 and K211 residues involved in sulfilimine bond formation between adjacent protomers. This may alter α4 chain interactions with other α chains, as supported by temporal and anatomic expression patterns of collagen IV chains during the zebrafish development. Despite the divergence between zebrafish and human α3 NC1 domain (endogenous angiogenesis inhibitor, Tumstatin), the zebrafish α3 NC1 domain exhibits conserved antiangiogenic activity in human endothelial cells.ConclusionsOur work supports type IV collagen is largely conserved between zebrafish and humans, with a possible difference involving the α4 chain.
Seizure control during spontaneous battery failure with responsive neurostimulation
Authors: Ward Ryan , Vallera Alexandra C. , Ali Irfan , Karakas Cemal , Haneef Zulfi 
Published: April 2023

AbstractObjectiveWe examined seizure control during spontaneous responsive neurostimulation (RNS) battery failure to investigate the persistent benefits of RNS in the absence of neurostimulation. We hypothesized that the loss of direct RNS does not immediately result in seizure worsening.MethodsPatients with RNS battery failure between August 2019 and December 2020 at a single institution were studied. During periods of battery depletion, the RNS device does not store any electrocorticography records, so we used a telephone‐based survey and chart review to assess seizure control during battery depletion.ResultsEight of 10 eligible participants responded to the survey, with a mean duration of battery failure of 36 days (range: 10–219 days). During battery depletion, one patient reported decreased seizures and five reported no changes in seizure frequency. Only two patients reported increased seizure frequency.SignificanceThe benefits of RNS treatment may outlast the immediate effects of direct neurostimulation, lending support to the notion of persistent neuroplasticity. Larger studies should confirm our preliminary findings.
The devil is in the details: Understanding how misinformation regarding epilepsy manifests in TikTok videos
Authors: Jiang Kallie , Nordli Douglas R. , Galan Fernando 
Published: April 2023

AbstractObjectiveThis study sought to understand the amount of misinformation surrounding epilepsy on the social media platform, TikTok.MethodsVideos from TikTok were searched using keyword “epilepsy.” In all, 109 videos were categorized as personal experience videos, event videos, or educational videos. Misinformation surrounding each video was analyzed by two independent reviewers. The number of videos and views of each were tracked.ResultsEvent videos garnered the most attention (80% of total views). Of the event videos, 26/47 contained misinformation in the form of calling a nonepileptic event an epileptic seizure (55%). Videos of nonepileptic events labeled as epileptic seizures amassed 109 956 400 views.SignificanceThis novel study quantifies the amount of misinformation regarding epilepsy on the social media platform, TikTok. The results showcase that misinformation is very prevalent on the application. Most of the misinformation consists of the mislabeling of nonepileptic events as epileptic seizures. Physicians should be aware of cardinal features of nonepileptic events to better treat patients. The medical community must understand the type of misinformation people are exposed to in order to educate patients appropriately.
Different relationships between epilepsy syndromes and autoimmune diseases
Authors: Chaves João , Leal Bárbara , Sardoeira Ana , Carvalho Vanessa , Samões Raquel , Freitas Joel , Chorão Rui , Ferreira Ana Marta , Brás Sandra , Lopes João , Ramalheira João , Lemos Carolina , Costa Paulo Pinho , Marinho António , da Silva Berta Martins , da Silva António Martins 
Published: April 2023

AbstractObjectiveOur objective was to study the relationship between epilepsy and autoimmune diseases in two different types of epilepsy: idiopathic generalized epilepsies (IGEs) and mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS). The contribution of the human leukocyte antigen (HLA) system to this relationship was analyzed.MethodsAdult patients with IGEs and MTLE‐HS at a tertiary epilepsy center were consecutively enrolled between January 2016 and December 2020.ResultsA total of 664 patients, 422 with IGEs and 242 with MTLE‐HS, were included. Patients with IGEs were 15 years younger, on average, than patients with MTLE‐HS (p < .001). The frequency of autoimmune diseases was 5.5% (n = 23) and 4.5% (n = 11) in patients with IGEs and MTLE‐HS, respectively (p = .716). The mean age of autoimmune disease onset was 20 ± 15.6 years in patients with IGEs and 36.7 ± 16.5 years in patients with MTLE‐HS (p < .05). Clinical manifestations of autoimmune diseases preceded epilepsy onset in 30.4% of patients with IGEs (i.e., in early childhood); in the other patients, epilepsy appeared before autoimmune disease onset. In all but one patient with MTLE‐HS and autoimmune diseases, the autoimmune diseases appeared after epilepsy onset from adolescence onward.SignificanceOur study indicates two relationship patterns: a bidirectional association between IGEs and autoimmune diseases and a unidirectional relationship between MTLE‐HS and autoimmune diseases. The involvement of genetic susceptibility factors (such as the HLA system), autoinflammatory mechanisms, female sex, and antiseizure medications in these relationships are discussed.