bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental smoking and risk of hypospadias: An updated meta-analysis of observational studies
Authors: Ye Zi-Han , Chen Hong-Song , Zhang Zhi-Cheng , Wang Xiao , Liu Xing , Wei Guang-Hui 
Published: February 2023

BackgroundInconsistent relationships have been shown between cigarette smoking and hypospadias in offspring. The purpose of this study was to summarize epidemiological evidence to evaluate the relationship between parental smoking and the risk of hypospadias.MethodsUp until October 2022, PubMed, EMBASE, Web of Science, and the Cochrane Library were systematically searched for qualified research. The summary RRs and 95% CIs were calculated using either a fixed-effects or a random-effects model. There were subgroup analyses undertaken to identify potential sources of heterogeneity.Results44 studies with 16,637,830 participants were included in our meta-analysis. Overall, maternal active smoking [risk ratio (RR) = 0.94; 95% confidence interval (CI): 0.90–0.99;P &lt; 0.01] was significantly associated with the risk of hypospadias. And neither paternal smoking (RR = 1.00; 95% CI: 0.86–1.15) nor maternal passive smoking (RR = 0.91; 95% CI: 0.60–1.23) was associated with the risk of hypospadias.ConclusionOur study discovered an association between maternal active smoking and a decreased risk of hypospadias, which may be due to the effect of smoking on androgen. However, as numerous studies have proved that cigarette smoking during pregnancy increases the risk of overall birth abnormalities in offspring, quitting cigarettes before pregnancy positively influences the health of offspring and should be advocated worldwide.Systematic review registration[www.crd.york.ac.uk/prospero], identifier [CRD42022319378].
Impact of hypertensive disorders of pregnancy on neonatal outcomes among infants born at 24+0–31+6 weeks’ gestation in China: A multicenter cohort study
Authors: Ge Jianfang , Gu Xinyue , Jiang Shanyu , Yang Ling , Li Xiaoyan , Jiang Siyuan , Jia Beibei , Chen Caihua , Cao Yun , Lee Shoo , Zhao Xiaopeng , Ji Yong , Zhou Wenhao 
Published: February 2023

ObjectiveTo describe the rate of hypertensive disorder of pregnancy (HDP) among mothers of very preterm infants (VPIs) admitted to Chinese neonatal intensive care units (NICUs), and to investigate the relationship between HDP and the outcomes of VPIs.Study designCohort study of all VPIs born at a gestational age of 24+0–31+6weeks and admitted to 57 tertiary NICUs of the Chinese Neonatal Network (CHNN) in 2019. Infants with severe congenital anomalies or missing maternal HDP information were excluded. Two multivariate logistic regression models were generated to assess the relationship between HDP and neonatal outcomes.ResultsAmong 9,262 infants enrolled, 1,744 (18.8%) infants were born to mothers with HDP, with an increasing incidence with increasing gestational age. VPIs born to mothers with HDP had higher gestational age but lower birth weight and were more likely to be small for gestational age. Mothers with HDP were more likely to receive antenatal steroids, MgSO4and cesarean section. Infants in the HDP group showed higher observed rates of mortality or any morbidity than infants in the non-HDP group (50.2% vs. 47.2%, crude odds ratio (OR) 1.13, 95% CI 1.02–1.26). However, the associations between HDP and adverse outcomes were not significant after adjustment. In the HDP group, mothers of 1,324/1,688 (78.4%) infants were diagnosed with preeclampsia/eclampsia. Infants born to mothers with preeclampsia/eclampsia had significantly lower odds of early death and severe retinopathy of prematurity.ConclusionsNearly one-fifth of VPIs were born to mothers with HDP in Chinese NICUs. No significant association was identified between HDP and adverse neonatal short-term outcomes of VPIs, while long-term follow-up of these infants is needed.
Case report: Idiopathic pulmonary fibrosis induced by nab-paclitaxel: A rare complication
Authors: Shen Jiahui , Wen Zhongyong , Lin Jingxia , Su Huiwen 
Published: February 2023

Background: Ovarian cancer is one of the deadliest gynecological cancers, with the most advanced disease and poor survival. Although BRCA genes play a key role in maintaining genomic stability and providing the possibility of clinically individualized treatments, with the emergence of new and more appropriate treatment options, new treatment–related adverse events are challenging and difficult for clinicians.Case presentation: An 80-year-old Chinese woman was diagnosed with stage IIIC ovarian high-grade serous adenocarcinoma (CT3cN1MX) with BRCA2 as the causative gene. She underwent three courses of neoadjuvant chemotherapy with nab-paclitaxel 400 mg and carboplatin 450 mg before surgery. Chest HRCT prior to chemotherapy demonstrated bilateral interstitial pneumonia. During chemotherapy, there were four episodes of dry cough, shortness of breath, dyspnea, and three episodes of bone marrow suppression. The symptoms became intermittent and progressively worse, and after three sessions of empirical cough and phlegm relief, oxygen inhalation, corticosteroids, anti-infectives, and leukopenia therapy, the symptoms became intermittent and progressively worse. The diagnosis of idiopathic pulmonary fibrosis came a week after the third round of chemotherapy. After a strong dose of corticosteroids and nintedanib anti-fibrosis therapy, the pulmonary symptoms abated, and intermediate tumor starvation was performed. The combination therapy was subsequently discontinued, and the patient experienced significant relief from pulmonary symptoms. Treatment response was positive following single-agent nab-paclitaxel 400 mg chemotherapy in combination with nintedanib 150 mg anti-fibrosis therapy.Conclusion: In this report, we describe a rare case of idiopathic pulmonary fibrosis associated with the use of nab-paclitaxel and carboplatin in ovarian cancer. During treatment, it is necessary to maintain a high level of vigilance for patients with interstitial pneumonia and engage the attention of clinicians to improve medication safety. Early diagnosis and anti-fibrosis therapy can reverse lung damage.
4-Methylesculetin ameliorates LPS-induced depression-like behavior through the inhibition of NLRP3 inflammasome
Authors: Choudhary Khushboo , Prasad Surendra Rajit , Lokhande Kiran Bharat , Murti Krishna , Singh Sanjiv , Ravichandiran Velayutham , Kumar Nitesh 
Published: February 2023

The pathophysiology of depression is heavily dependent on inflammation. Evidence suggests that the etiology of depression is linked with NLRP3 inflammasome-induced inflammation. Therefore, blocking the activated NLRP3 inflammasome may be beneficial for treating depression. Due to the limitations of currently available antidepressants, it is necessary to develop novel, safe, and affordable drugs for the treatment of depression. A natural coumarin derivative named 4-methylesculetin (4-MESC) possesses anti-inflammatory properties. However, the role of 4-MESC as an antidepressant has not been elucidated. Therefore, in this study, we explored the antidepressant-like effects of 4-MESC and its underlying molecular mechanism through the modulation of the NLRP3 inflammasome. The docking and molecular dynamic simulation studies revealed that 4-MESC has a higher affinity for the NLRP3 PYD. Blood–brain barrier permeability was confirmed using the SwissADME pharmacokinetic tool. High doses (50 mg/kg) of 4-MESC significantly reduced the immobility duration in the tail-suspension test (TST) and forced swim test (FST) without changing the overall locomotor activity in the female Swiss albino mice that were subjected to lipopolysaccharide (LPS). LPS-induced pro-inflammatory cytokines such as IL-6 and TNF-α were reduced in serum and brain tissues using 4-MESC. 4-MESC’s neuroprotective effects are mediated by increased brain-derived neurotrophic factor (BDNF) and decreased cortisol levels. 4-MESC markedly reduced LPS-induced elevated levels of ROS and lipid peroxidation (malondialdehyde levels) and enhanced the superoxide dismutase (SOD) activity and glutathione levels, which revealed its anti-oxidant potential against oxidative stress. 4-MESC diminished the expression levels of NF-κBp65, IL-6, NLRP3, caspase-1, gasdermin D, and IL-1β in the hippocampus. These findings demonstrated that 4-MESC exhibited antidepressant-like effects by inhibiting the NLRP3 inflammasome. However, other antidepressant mechanisms might also be involved which require further studies.
Human PARP1 substrates and regulators of its catalytic activity: An updated overview
Authors: Zhu Tao , Zheng Ju-Yan , Huang Ling-Ling , Wang Yan-Hong , Yao Di-Fei , Dai Hai-Bin 
Published: February 2023

Poly (ADP-ribose) polymerase 1 (PARP1) is a key DNA damage sensor that is recruited to damaged sites after DNA strand breaks to initiate DNA repair. This is achieved by catalyzing attachment of ADP-ribose moieties, which are donated from NAD+, on the amino acid residues of itself or other acceptor proteins. PARP inhibitors (PARPi) that inhibit PARP catalytic activity and induce PARP trapping are commonly used for treating BRCA1/2-deficient breast and ovarian cancers through synergistic lethality. Unfortunately, resistance to PARPi frequently occurs. In this review, we present the novel substrates and regulators of the PARP1-catalyzed poly (ADP-ribosyl)ation (PARylatison) that have been identified in the last 3 years. The overall aim is the presentation of protein interactions of potential therapeutic intervention for overcoming the resistance to PARPi.
High-SMSR wavelength-swept laser with a CL-band mode-hopping free tuning range
Authors: Qiao Shan , Sheng Liwen , Huang Lin , Zhang Aiguo , Wei Yu , Liu Zhiming , Ju Junwei , Zhang Zhihui , Yin Bingqi , Li Peng , Han Jilei , Zhang Yiqi , Qu Tianyang 
Published: February 2023

A high side-mode suppression ratio external-cavity wavelength-swept laser system with a wide mode-hopping free tuning range is developed. The proposed wavelength-swept laser is based on a single-angled facet gain chip in a classical Littman-Metcalf external-cavity configuration using a blazed diffraction grating as the feedback element. The output power, side-mode suppression ratio, and tunable range of the external-cavity wavelength-swept laser system are experimentally measured. Wide mode-hopping-free continuous wavelength tuning range about 100 nm in CL-band with a side-mode suppression ratio of more than 65.64 dB are realized. An output optical power of more than 14.12 dBm over the entire tunable region can also be achieved. The proposed external-cavity wavelength-swept laser system allows simultaneously high side-mode suppression ratio and no mode-hopping tunable radiation, thus opening a door for practical applications such as optical modulation schemes.
Magnesium improved fruit quality by regulating photosynthetic nitrogen use efficiency, carbon–nitrogen metabolism, and anthocyanin biosynthesis in ‘Red Fuji’ apple
Authors: Tian Ge , Qin Hanhan , Liu Chunling , Xing Yue , Feng Ziquan , Xu Xinxiang , Liu Jingquan , Lyu Mengxue , Jiang Han , Zhu Zhanling , Jiang Yuanmao , Ge Shunfeng 
Published: February 2023

IntroductionBoth nitrogen (N) and magnesium (Mg) play important roles in biochemical and physiological processes in plants. However, the application of excessive N and insufficient Mg may be the factor leading to low nitrogen utilization rate (NUE) and fruit quality degradation in apple production.MethodsIn this study, we analyzed the effects of different application rates of Mg (0, 50, 100, 150, 200 kg/ha) on the photosynthetic nitrogen use efficiency (PNUE), the accumulation and distribution of carbon (C), N metabolism, anthocyanin biosynthesis and fruit quality of the ‘Red Fuji’ apple in 2018 and 2019.ResultsThe results showed that the application of Mg significantly increased the 15NUE and increased the allocation rate of 15N in the leaves whereas the 15N allocation rate in the perennial organs and fruits was decreased. With the increase in Mg supply, the activities of N metabolism enzymes (NiR, GS, and GOGAT) were significantly promoted and the content of intermediate products in N metabolism (NO2−, NH4+, and free amino acid) was significantly decreased. Furthermore, an appropriate rate of Mg significantly promoted the net photosynthetic rate (Pn) and photosynthetic nitrogen use efficiency (PNUE), enhanced the enzyme activities of C metabolism (SS, SPS, S6PDH), and increased the contents of sorbitol and sucrose in leaves. In addition, Mg upregulated the gene expression of sugar transporters (MdSOT1, MdSOT3, MdSUT1, and MdSUT4) in fruit stalk and fruit fresh; 13C isotope tracer technology also showed that Mg significantly increased the 13C allocation in the fruits. Mg also significantly increased the expression of anthocyanin biosynthesis genes (MdCHS and MdF3H) and transcription factors (MdMYB1 and MdbZIP44) and the content of anthocyanin in apple peel.ConclusionThe comprehensive analysis showed that the appropriate application of Mg (150 kg/ha) promoted PNUE, C–N metabolism, and anthocyanin biosynthesis in apple trees.
Effects of wingwave® on athletes’ wellbeing and fluidity of gaze behavior
Authors: Weiland Frank Peter Gadso , Noël Benjamin , Klatt Stefanie 
Published: February 2023

IntroductionThe wingwave® method combining a muscular test and elements of eye movement desensitization and reprocessing has been found to successfully reduce anxiety and improve relaxation in people. However, it is still unclear how exactly its application improves individual wellbeing (though it is assumed to be related to changes in gaze patterns) and if it works for team sport athletes.MethodTo test both, team sport athletes who had reported a problem with a team sport aspect were randomly assigned to an experimental group and a control group. The experimental group members were individually coached by a wingwave® coach once while the other participants watched a tennis match instead.ResultsResults showed that athletes in the wingwave® group benefited from the coaching as their individual perception of their problems improved. These improvements were associated with a decrease of catch-up saccades in a visual object-tracking task conducted before and immediately after coaching.DiscussionThis points to wingwave® interventions affecting gaze behavior and consequently wellbeing of team sport athletes.
Nurses’ perceptions of the ISBAR handover protocol and its relationship to the quality of handover: A case study of bilingual nurses
Authors: Pun Jack 
Published: February 2023

IntroductionPoor communication at handover may cause harm to the patient. Despite numerous studies promoting ISBAR as a communication tool for structured handover, nurses have varied levels of understanding of the ISBAR tool; this may lead to different perceptions. This paper aims to explore the structural relationships between factors relating to handover communication among nurses.MethodA path analysis was conducted to analyse how 206 bilingual nurses’ knowledge of the ISBAR affects the perceived quality of handover, using a validated Nursing Handover Perception Questionnaire.ResultsNurses’ knowledge of the ISBAR was not a statistically significant factor affecting the perceived quality of handover. Rather, nurses’ understanding of patients’ care plans and receiving updated information about patients determine the perceived quality of handover.DiscussionNurses’ compliance with the ISBAR tool should be considered in order to further identify and develop effective communication skills. Nurses’ understanding of patients’ care plans and receiving updated patient information significantly corresponded to the perceived quality of handover.
The impact of gender differences in teachers’ teaching practices and attitudes on students’ math and science achievement in Saudi Arabia: Evidence from TIMSS 2019 data
Authors: Alnahdi Ghaleb Hamad , Schwab Susanne 
Published: February 2023

Previous results from large-scale studies often identified a gender gap in achievement outcomes between girls and boys. This study aims to investigate the existence of a relationship between students’ grades and gender differences in practices and attitudes among teachers. Data from the Saudi Arabian TIMSS 2019 were analyzed for this study. The dataset contains data from 10,817 4th grade students (5,447 girls and 5,370 boys) who took math and science as well as data from their 437 teachers (around 50% were female teachers). The results showed that teachers’ teaching practices were positively associated with students’ scores in math and science. In addition, teachers’ attitudes toward teaching were positively associated with students’ scores. Female teachers held more positive attitudes toward teaching and were rated more positively in terms of practices by their students.Highlights– Teacher practices were positively associated with students’ achievement.– Teachers’ attitudes were positively associated with students’ achievement.– Female teachers hold more positive attitudes toward teaching.– There are differences in teaching style and practices based on gender.
Prosocial behavior in toddlerhood and early childhood: Consistency across subtypes and over time
Authors: Paz Yael , Davidov Maayan , Orlitsky Tal , Hayut Mor , Roth-Hanania Ronit , Zahn-Waxler Carolyn 
Published: February 2023

IntroductionYoung children show their capacity for compassion and their desire to enhance the welfare of others in multiple ways. The present study sought to address gaps in knowledge regarding prosociality in the early years. Specifically, the study examined whether different subtypes of prosociality are interrelated, whether they are consistent over time, as well as the meaning of young children’s spontaneous versus cued prosocial behavior.MethodsIn a longitudinal sample (N= 151), three subtypes of prosocial behavior—instrumental helping, compassionate helping (comforting), and sharing—were assessed using behavioral tasks in toddlerhood (18 months) and early childhood (36 months).ResultsConsistent with hypothesis, partial convergence was found between the different prosociality subtypes at each age. There was also modest continuity over time, both within and across prosocial subtypes. Moreover, at both ages, when children helped or shared spontaneously, they also provided more assistance in the task. Children’s tendency to assist spontaneously was partially consistent across situations by early childhood.DiscussionThe findings indicate that a moderately stable disposition toward prosociality is already evident during early ontogeny. Moreover, different subtypes of prosocial behavior are distinct yet interrelated in the early years, suggesting they have both common and unique underlying mechanisms. Lastly, young children’s spontaneous (versus cued) prosocial action appears to reflect both motivational and cognitive processes.
Trends and risk factors of stillbirth among women of reproductive age in Pakistan: A multivariate decomposition analysis
Authors: Shakeel Abeera , Kamal Asifa , Ijaz Muhammad , Siddiqa Maryam , Tesema Getayeneh Antehunegn , Abushal Tahani 
Published: February 2023

BackgroundEvery year, 2 million babies are stillborn in the world. Globally, there has been a decline in the stillbirth rate of 2%. Despite advancements in prenatal care and the implementation of new medical technologies, the incidence of early stillbirths remains unchanged. A slight decrease in the rate of late-term stillbirth has been observed. Pakistan ranked third in South Asia for having the highest stillbirth rate. Compared to its neighbors and other developing nations, Pakistan has shown a lack of progress in reducing maternal and neonatal fatalities. Therefore, the purpose of this study is to use a multivariate decomposition analysis to examine the trends and factors that have contributed to the change in the stillbirth rate over time.MethodsTo conduct this study, we used a secondary data analysis approach and analyzed data from the Pakistan Demographic and Health Survey (PDHS) of 2012–2013 and 2017–2018). For the analysis, a total sample of 15,068 births in 2017–2018 and 13,558 births in the PDHS from 2012 to 2013 were taken into account. Using the MVDCMP function within STATA version 15 statistical software, a logit-based multivariate decomposition model was fitted to determine the variables that influence the change in stillbirth. The current study used two cross-sectional surveys to identify important risk factors for stillbirths.ResultsOver the past 5 years, Pakistan's stillbirth rate has risen from 3.98 to 5.75%. According to the total multivariate decomposition analysis, the change in coefficient (change in the effect of attributes) accounted for 81.17% of the overall change in the proportion of stillbirths. In contrast, the change in endowment was not statistically significant. Changes in maternal education, individual and community-level wealth status, and mode of delivery all significantly impacted the rate of stillbirths over time.ConclusionStillbirths increased in Pakistan from 2012 to 2017. Stillbirths are observed more frequently for women residing in Punjab, Sindh, and rural areas. A major concern that is directly related to the prevalence of stillbirths in Pakistan is the lack of accessible, affordable, and high-quality maternal healthcare facilities. Older, overweight, and uneducated women are more likely to have stillbirths than women who deliver vaginally. High parity and short birth intervals also accelerated the rate of stillbirths. An effective remedy to control stillbirths is the provision of accessible and affordable healthcare services. Awareness campaigns for the health education of pregnant women should focus on raising awareness to support better pregnancy outcomes for poor women living in communities with higher education levels. The risk of stillbirth can be reduced by offering free diagnostics for early detection of birth complications in low-resource settings and referring these cases to knowledgeable gynecologists for safe delivery.
A scoping Review of Tools to Evaluate Existing Playgrounds for Inclusivity of Children with Disabilities
Authors: Taylor Leah G. , Primucci Mara , Vanderloo Leigh M. , Arbour-Nicitopoulos Kelly P. , Leo Jennifer , Gilliland Jason , Tucker Patricia 
Published: February 2023

IntroductionChildren with disabilities may be unable engage playground spaces due to barriers exacerbating exclusion. Therefore, clarity on how to evaluate existing playgrounds for inclusivity of children with disabilities is required.MethodsA scoping review was undertaken to explore auditing tools.ResultsFourteen white and grey literature resources were identified. The term “inclusion” was operationalized differently across tools, primarily focusing on physical accessibility. Characteristics of the tools were synthesized into 13 inclusive design recommendations for playgrounds. Two tools showed promise, evaluating 12/13 recommendations.DiscussionThe results of this review provide guidance on existing tools for evaluating playgrounds for inclusion for community stakeholders and researchers.Systematic Review Registrationhttps://osf.io/rycmj.