bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptable clinical outcomes despite high reoperation rate at minimum 12-month follow-up after concomitant arthroscopically assisted anterior cruciate ligament reconstruction and medial meniscal allograft transplantation
Authors: Shankar Dhruv S. , Vasavada Kinjal D. , Avila Amanda , DeClouette Brittany , Aziz Hadi , Strauss Eric J. , Alaia Michael J. , Jazrawi Laith M. , Gonzalez-Lomas Guillem , Campbell Kirk A. 
Published: January 2023

Abstract
Background
Single-stage medial meniscus allograft transplantation (MAT) with concomitant anterior cruciate ligament reconstruction (ACLR) is a technically challenging procedure for management of knee pain and instability in younger patients, but clinical and functional outcomes data are sparse. The purpose of this study was to assess surgical and patient-reported outcomes following concomitant ACLR and medial MAT.

Methods
We conducted a retrospective case series of patients who underwent medial MAT with concomitant primary or revision ACLR at our institution from 2010 to 2021 and had minimum 12-month follow-up. Complications, reoperations, visual analog scale (VAS) pain, satisfaction, Lysholm score, return to sport, and return to work outcomes were assessed. Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference, Pain Intensity, and Physical Function Scores were used to measure patients’ functional status relative to the US population. P-values < 0.05 were considered significant.

Results
The cohort consisted of 17 knees of 16 individual patients. The cohort was majority male (82.4%) with mean age of 31.9 years (range 19–49 years) and mean body mass index (BMI) of 27.9 kg/m2 (range 22.5–53.3 kg/m2). Mean follow-up time was 56.8 months (range 13–106 months). Most patients underwent revision ACLR (64.7%). The 1-year reoperation rate was high (23.5%), with two patients (11.8%) tearing their meniscus graft. Patient-reported outcomes indicated low VAS pain (mean 2.2), high satisfaction (mean 77.9%), and fair Lysholm score (mean 81.1). Return to work rate was high (92.9%), while return to sport rate was low (42.9%). Postoperative PROMIS scores were comparable or superior to the national average and correlated significantly with patient satisfaction (p < 0.05).

Conclusions
The concomitant ACLR and MAT procedure is associated with excellent knee pain and functional outcomes and high rate of return to work after surgery, though the 1-year reoperation rate is high and rate of return to sport is low.
Level of evidence: IV.
Circulating expression patterns of TL1A and FFAR2 in patients with stable and unstable angina
Authors: Kamel Amira A. , Taha Salma , Mosa Aliaa A. 
Published: January 2023

AbstractBackground and aimThe primary factor in sudden cardiac death is coronary artery disease. We intended to discover the diagnostic worth of circulating tumor necrosis factor like cytokine 1A (TL1A) and free fatty acid receptor 2 (FFAR2) as early, noninvasive indicators for individuals with stable angina (SA) and unstable angina (UA).MethodsIn all, 90 people were enrolled in the current case–control study: 30 patients with SA, 30 patients with UA, and 30 healthy volunteers. Circulating TL1A and FFAR2 gene expression levels were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). FBG, TC, TG, and HDL-C were assessed by spectrophotometry, while hs-CRP and troponin T were measured by ELISA.ResultsCirculating TL1A expression was significantly elevated in SA (P < 0.001) and UA patients (P < 0.001) as compared to controls and also was significantly higher in UA patients (P < 0.001) as compared to SA patients. Circulating FFAR2 expression was significantly decreased in SA (P < 0.001) and UA patients (P < 0.001) in comparison with controls and was significantly lowered in UA patients (P = 0.001) in comparison with SA patients. Our results show that TL1A and FFAR2 were sensitive and specific biomarkers for discriminating SA patients from controls. Moreover, TL1A and FFAR2 displayed a remarkable ability to distinguish UA from SA. Multivariate regression analysis revealed that TL1A, FFAR2, FBG, TC, TG, LDL-C, and Troponin T were independent risk factors for SA, while TL1A, TG, and hs-CRP were independent risk factors for UA. TL1A has a significant positive correlation with LDL-C (r = 0.406,P = 0.001), hs-CRP (r = 0.673,P < 0.001), and troponin T (r = 0.653,P < 0.001). There was a significant inverse relationship between FFAR2 and each of TL1A (r = − 0.858,P < 0.001), FBG (r = − 0.325,P = 0.011), TC(r = − 0.306,P = 0.017), TG (r = − 0.368,P = 0.004), LDL-C (r = − 0.413,P = 0.001), hs-CRP (r = − 0.737,P < 0.001), and troponin T (r = − 0.715,P < 0.001).ConclusionGene expression of TL1A and FFAR2 is a good new blood-based molecular indicator for early detection of SA and UA. Early detection of a possible UA is crucial for initiating appropriate treatment that results in better patient health.
Ocular motor impairment in early-stage multiple sclerosis: a video-oculography assessment
Authors: Ouattassi Naouar , El Ghoul Salma El Alaoui , Bouchal Siham , Belahssen Mohammed Faouzi , Ridal Mohammed , El Alami Mohammed Nouredine El Amine 
Published: January 2023

Abstract
Background
Eye movement disorders in multiple sclerosis (MS) are frequently misdiagnosed and frequently overlooked during clinical examinations. Even at a preclinical state, these defects frequently cause impairment and weariness.

Methods
We conducted a cross-sectional observational study including 20 individuals with a confirmed MS diagnosis. The inclusion criteria were an EDSS score of 4 or less and a 6-month interval between the last relapse and enrolment. As part of the MS assessment, a routine ORL, neurology exam, eye exam, assessment of eye movement using Ulmer’s videonystagmography battery tests, and routine brain MRI were performed on the patient.

Results
A total of 75% of the patients in our series are female, with a mean age of 39 years and a range of 24 to 59 years. The average age of MS onset is 32 years. The relapsing-remitting type of multiple sclerosis (RRMS) accounts for 95% of all cases. There is only a single case of secondary progressive disease course (SPMS). Principal VNG manifestations are related to subclinical eye movements abnormalities. Rotatory vertigo caused by vestibular dysfunction was less prevalent than other balance disorders. There were found to be two types of nystagmus: pendular and central positional nystagmus.

Discussion and conclusion
VNG is sensitive for detecting vestibular system dysfunction in MS patients. It is also beneficial for diagnosing subtle eye movement abnormalities that are usually overlooked.
Predicting total organic carbon from well logs based on deep spatial-sequential graph convolutional network
Authors: Shan Xiaocai , Chen Zhangxin , Fu Boye , Zhang Wang , Li Jing , Wu Keliu 
Published: January 2023

The total organic carbon (TOC) is a key geologic parameter for unconventional reservoirs. Conventional empirical [Formula: see text] methods cannot handle the nonlinear relationships between the characteristics of TOC and its well-log responses. Increased data availability has the potential to speed up deep learning applications, which can reasonably propagate the integrated information from well logs to indirectly observable geologic properties, such as TOC. Although the existing convolutional neural network (CNN) has found superior performance to [Formula: see text] for predicting TOC, CNNs feature-learning capability is still constrained by the fact that it can only extract log-specific sequential features of the input logs. However, the cross-log topological association features are potentially essential for the nonlinear mapping between well logs and TOC. Thus, we introduce a novel deep spatial-sequential graph convolutional network (SSGCN) for predicting the TOC by jointly leveraging the cross-log topological association features and log-specific sequential features. Through further use of the previously unaccounted topological interactions, our SSGCN dramatically outperforms the sequence-based CNN. In the southeast Sichuan Basin, SSGCN exhibits beneficial mapping not demonstrated previously: its models achieve a better cross-validation performance within the same gas field wells and a greater generalizability in another gas field well. Our SSGCN method can predict TOC of shale gas field well with the best [Formula: see text] being 0.87 within 1 s on the CPU of a desktop computer, which increases the efficiency of obtaining the TOC parameter. From this study, we recommend graph and sequential convolutions for designing deep learning architectures in the well-log analysis.
A multiple-point stochastic-based turbidite lobe architecture geomodeling: A case study from L Oilfield, Lower Congo Basin, West Africa
Authors: Xu Rui , Zhang Wenbiao , Li Meng , Lu Wenming 
Published: January 2023

As a prominent component of turbidite deposition systems, turbidite lobe internal architecture characterization has proven essential due to its complicated sedimentary hierarchy and evident heterogeneity. This paper demonstrates an integrated methodology for doing a multiple-point stochastic (MPS) simulation of deepwater turbidite single-lobe architecture. Based on the logging data, high-frequency seismic data, thorough architectural feature analysis, and 3D training image, MPS-based geologic modeling of the Miocene turbidite lobe reservoir in the Lower Congo Basin is carried out. This effort has two objectives: (1) to expand the geologic knowledge base of deepwater turbidite lobes with morphology parameters and (2) to develop a process of turbidite geomodeling that could characterize the architectural hierarchy of a single lobe with limited difficult data. As a first step, we analyze and characterize properties of the single-lobe element characteristics and the manner of sedimentary dispersion using 145 m long cores, well logging, and seismic analysis. Second, shallow seismic-based turbidite lobes pick-up and morphology parameter measurements have been conducted to collect quantitative characteristics of turbidite lobe and will be used as geomodeling guidance. Third, a 3D lobe complex training image with single-lobe architecture elements superposition is derived by a seismic geobody caving (using threshold truncation) and enhanced based on the sedimentary distribution mode. An MPS simulation incorporating well data, morphological parameters, training image, and seismic inversion constraint is then performed, which results in obtaining an architecture model that could describe a single lobe. The simulation results generally followed the lobe architecture elements morphology and superposition. The coincidence between the MPS simulated turbidites lobe complex architecture model and the posterior well could reach up to 86%. The paper gives the methodology for a case study that proved the implementation of single turbidite lobe architectural characterization using an MPS, and the recommended process could be applied to other fields.
Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study
Authors: Wolpe Noham , Chen Shanquan , Kirkpatrick Brian , Jones Peter B. , Jenkins Christopher , Cardinal Rudolf N. , Fernandez-Egea Emilio 
Published: January 2023

SummaryNegative symptoms of schizophrenia manifest as reduced motivation and pleasure (MAP) and impaired emotional expressivity (EXP). These can occur as primary phenomena, but have also been suggested to occur secondary to other clinical factors, including antipsychotic-induced sedation. However, this relationship has not been established formally. Here, we examined the effect of antipsychotic-induced sedation (assessed via the proxy of total daily sleep duration) on MAP and EXP in a cohort of 187 clozapine-treated patients with schizophrenia followed for over 2 years on average, using multilevel regression and mediation models. MAP, but not EXP, was adversely influenced by sedation, independently of the severity of psychosis or depression. Moreover, clozapine impaired MAP indirectly by worsening sedation, but after accounting for clozapine-induced sedation, clozapine improved MAP. Our results highlight the importance of addressing sedative side-effects of antipsychotics to improve clinical outcomes.
GliaMorph: a modular image analysis toolkit to quantify Müller glial cell morphology
Authors: Kugler Elisabeth , Bravo Isabel , Durmishi Xhuljana , Marcotti Stefania , Beqiri Sara , Carrington Alicia , Stramer Brian , Mattar Pierre , MacDonald Ryan B. 
Published: January 2023

ABSTRACT
Cell morphology is crucial for all cell functions. This is particularly true for glial cells as they rely on complex shape to contact and support neurons. However, methods to quantify complex glial cell shape accurately and reproducibly are lacking. To address this, we developed the image analysis pipeline ‘GliaMorph’. GliaMorph is a modular analysis toolkit developed to perform (1) image pre-processing, (2) semi-automatic region-of-interest selection, (3) apicobasal texture analysis, (4) glia segmentation, and (5) cell feature quantification. Müller glia (MG) have a stereotypic shape linked to their maturation and physiological status. Here, we characterized MG on three levels: (1) global image-level, (2) apicobasal texture, and (3) regional apicobasal vertical-to-horizontal alignment. Using GliaMorph, we quantified MG development on a global and single-cell level, showing increased feature elaboration and subcellular morphological rearrangement in the zebrafish retina. As proof of principle, we analysed expression changes in a mouse glaucoma model, identifying subcellular protein localization changes in MG. Together, these data demonstrate that GliaMorph enables an in-depth understanding of MG morphology in the developing and diseased retina.
The average age of first marriage for Indonesian women in their reproductive period who give birth to an average of two children: National survey (2017 – 2019)
Authors: Ekoriano Mario , Muthmainnah Muthmainnah , Titisari Anastasia , Devi Yuli Puspita , Widodo Teguh , Purwoko Edy 
Published: January 2023

Background: The results of the 2020 population census in Indonesia showed that the population has reached 270.020.000 million. This number shows that the population in Indonesia during the last 10 years has increased by around 32,56 million people. One of the BKKBN's efforts to reduce the birth rate in Indonesia is to urge people to marry at the ideal age, 21 years for women and 25 years for men. Methods: This study used GPAS/ SKAP data for the period 2017, 2018, and 2019 using the module for women aged (15-49) and the sample used was all women aged 40-49. This analysis used secondary data from the 2017, 2018, and 2019 government performance and accountability surveys. Results: The age at first marriage for women should be encouraged to be 25 years old, not 21 years old, which has always been echoed and socialized. Age at first marriage is the most dominant factor in women aged (40-49) to have more than two children (2017 SOR: 4.17 95% CI [1.85-17.31], (2018 SOR: 57.14 99% [4.12-793.67]) (2019 SOR 21.22 99% CI [2.28-197.45]), while only in 2019 the AFM variable after controlling for it remained significant in influencing having children more than 2 (AOR 27.64 99% [2.88-265.20]). Conclusion: Women aged (40-49) who have a younger age at first marriage (10-24) have a longer reproductive age range, so they have relatively more children than women who married at the age of 25 and over. After controlling for other factors, the characteristics of women who have a tendency to have more than two children. Therefore, it is necessary to design a health strategy that is more suitable to the needs, characteristics, and capacity of women to reduce the birth rate in Indonesia is to urge people to marry at the ideal age.
Interventions for supporting self-management in people with musculoskeletal pain, including focus on varying levels of health literacy: A systematic overview of reviews
Authors: Babatunde Opeyemi O , Corp Nadia , Shivji Noureen , Rowlands Gill , Quicke Jonathan , Healey Emma L , Protheroe Joanne , van der Windt Danielle A 
Published: January 2023

Background: Musculoskeletal (MSK) pain is a major cause of disability globally, affecting one in three adults. Self-management is a core recommendation for managing MSK pain; however, most self-management programmes require a high level of patient engagement, which may be partly influenced by health literacy levels. This overview aims to summarise current evidence on supported self-management and the influence of varying levels of health literacy in people with MSK pain. Methods: A systematic search was conducted for relevant systematic reviews in databases (Cochrane Library, Medline, EMBASE, CINAHLPlus, AMED, and PsycInfo). Data on study populations (including markers of health literacy), characteristics, and outcomes of supported self-management such as self-efficacy in pain management were extracted. Quality of systematic reviews was assessed using AMSTAR 2, and strength of evidence rated using a modified GRADE approach. Results: In total, 40 systematic reviews contributed evidence to this overview. Based on intervention components and mode of delivery, three main self-management intervention approaches were indicated: structured self-management education programmes (10 reviews), self-directed self-management (four reviews), and combined self-management activity and education programmes (26 reviews). MSK patients with low health literacy levels were found to have poorer outcomes with current self-management interventions. The strength of evidence for self-efficacy in pain management was assessed as low (across the three approaches). Only one review systematically extracted data on measures or markers of health literacy, highlighting an important gap in evidence. Conclusions: A comprehensive summary and critical assessment of current evidence on supported self-management and the influence of health literacy levels among patients with MSK pain was presented. There is a gap in evidence regarding potential mediators of the effects of supported self-management among people with musculoskeletal conditions and low levels of health literacy, thereby limiting the opportunity to positively influence outcomes.
Changing birthplaces to care for healthcare workers, lessons from the pandemic: A scoping review
Authors: Melacca Alessia , Urso Claudia , Calleja-Agius Jean , Gouni Olga , Gabbianelli Rosita , Lalor Joan , Morano Sandra 
Published: January 2023

Background: Together with women giving birth, healthcare professionals involved in perinatal care faced significant challenges due to Covid-19 restrictions. The birth environment has been affected, influencing the quality and nature of interactions between care providers, women, and their families as well as the quality of care provided to women. Aim: To identify, categorize and reflect on the most relevant aspects of the experience of healthcare workers, especially obstetricians and gynecologists, involved in the peripartum period, after the first wave of the Covid-19 pandemic up till now. Methods: A scoping review was conducted. After conducting a literature search using a variety of online data- bases, 22 articles were included, and the main/recurrent themes were identified. Results: The following main themes were described: fear of the virus, changes in the way care is provided, increase in the workload, mental health, psychological distress, support strategies, university education, and perspectives of health managers. Discussion: Standard maternity departments appeared not appropriate to face the pandemic. Psychological distress on perinatal healthcare workers’, the majority of whom were women, led to the impairment of their mental health, affecting the quality of care provided to women. A key role was played by healthcare managers support in shaping how doctors can cope and recover, and in reducing the mental health impact. Conclusion: It is very important to address some of the most relevant issues to acknowledge the role of healthcare workers and improve the health systems organization to face future pandemics.
Pharmacokinetics and pharmacodynamics of azithromycin in severe malaria bacterial co-infection in African children (TABS-PKPD): a protocol for a Phase II randomised controlled trial
Authors: Olupot-Olupot Peter , Okiror William , Mnjalla Hellen , Muhindo Rita , Uyoga Sophie , Mpoya Ayub , Williams Thomas N , terHeine Rob , Burger David M , Urban Britta , Connon Roisin , George Elizabeth C , Gibb Diana M , Walker A Sarah , Maitland Kathryn 
Published: January 2023

Background: African children with severe malaria are susceptible to Gram-negative bacterial co-infection, largely non-typhoidal Salmonellae, leading to a substantially higher rates of in-hospital and post-discharge mortality than those without bacteraemia. Current evidence for treating co-infection is lacking, and there is no consensus on the dosage or length of treatment required. We therefore aimed to establish the appropriate dose of oral dispersible azithromycin as an antimicrobial treatment for children with severe malaria and to investigate whether antibiotics can be targeted to those at greatest risk of bacterial co-infection using clinical criteria alone or in combination with rapid diagnostic biomarker tests. Methods: A Phase I/II open-label trial comparing three doses of azithromycin: 10, 15 and 20 mg/kg spanning the lowest to highest mg/kg doses previously demonstrated to be equally effective as parenteral treatment for other salmonellae infection. Children with the highest risk of bacterial infection will receive five days of azithromycin and followed for 90 days. We will generate relevant pharmacokinetic data by sparse sampling during dosing intervals. We will use population pharmacokinetic modelling to determine the optimal azithromycin dose in severe malaria and investigate azithromycin exposure to change in C-reactive protein, a putative marker of sepsis at 72 hours, and microbiological cure (seven-day), alone and as a composite with seven-day survival. We will also evaluate whether a combination of clinical, point-of-care diagnostic tests, and/or biomarkers can accurately identify the sub-group of severe malaria with culture-proven bacteraemia by comparison with a control cohort of children hospitalized with severe malaria at low risk of bacterial co-infection. Discussion: We plan to study azithromycin because of its favourable microbiological spectrum, its inherent antimalarial and immunomodulatory properties and dosing and safety profile. This study will generate new data to inform the design and sample size for definitive Phase III trial evaluation. Registration: ISRCTN49726849 (27th October 2017).