bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjudicating a Diverse Humanity
Authors: Kalaycioglu Elif 
Published: February 2025

Abstract
This chapter analyzes the regime’s implementation between 1994 and 2010, under the partial paradigm shift of the Global Strategy. With that change, two iterations of humanity began to circulate in the regime. The first is the original vision of a rarefied humanity, attached to art and world-historical resources, and facilitating the pursuit of civilizational, world-making subjectivities. The second is a diverse humanity constructed through anthropological resources, such as vernacular and living cultures. I analyze the complex negotiations of subjectivity that take place at this intersection by focusing on nominations from Africa, as the Global Strategy’s priority region. I locate these negotiations in a broader and fraught context, marked by debates on what universal value means in relation to a diverse humanity, and who can adjudicate it. The chapter concludes with the implications of these dynamics for peace and solidarity, including their more robust possibilities, which emerge from the nested narratives of humanity put forth by nominations associated with the history of the slave trade.
The Oxford English Literary History
Authors: Eisaman Maus Katharine 
Published: February 2025

Abstract
This book surveys the rich English literary tradition, 1603–1660, in the context of the eventful decades between the accession of James I and the restoration of Charles II. Part I describes the ‘social rules of writing’. Who could become a writer in the early seventeenth century? How could a literary career be pursued? How was literary work disseminated? And how did those practices change between 1603 and 1660? Part II of the book discusses the period’s most innovative and important literary genres. Genres that receive special attention include satiric city comedy, country house poetry, chorography, masque, tragedy, tragicomedy, religious poetry, epic, the poetry of love and friendship, and a variety of kinds of prose.
A Sense of Place
Authors: Eisaman Maus Katharine 
Published: February 2025

Abstract
Several distinctive new genres developed or revived in the early seventeenth century evoke particular places: satiric city comedy, ‘country house’ and prospect poetry, and ‘chorography’ or the literary mapping of England. This chapter considers these various kinds of ‘place poetry’ together, arguing that they share a set of common concerns, contrasting an imagined ‘rural’ ethos with disturbing but exciting ‘urban’ innovations, reflecting upon changing political realities and the future of a society in turmoil. Writers discussed include Ben Jonson, Thomas Middleton, Aemelia Lanyer, Thomas Carew, Andrew Marvell, Michael Drayton, and John Denham. Foreign and exotic places are more characteristic of masque, tragedy, and tragicomedy, which will be covered in Chapter 5.
A Hybrid View of Commitment
Authors: Alonso Facundo M 
Published: February 2025

Abstract
We often appeal to the notion of an agent’s commitment to action to characterize, for example, an agent’s faithfulness to a promise she has given to another, her robust disposition to pursue a goal she values or cares about, and her determination to stick to that goal. In the philosophy of action, that notion is often associated with the idea of an agent’s intention to act. In ethics, it is primarily associated with the idea of an agent’s commitment to, or endorsement of, a certain norm. This chapter argues that both these ideas, of intention and of normative endorsement, are central to the—or, at least, an—ordinary notion of an agent’s (psychological) commitment to action. In so doing, the chapter also sheds light on important features of intention.
Noninvasive fetal genotyping using deep neural networks
Authors: Schwammenthal Yonathan , Rabinowitz Tom , Basel-Salmon Lina , Tomashov-Matar Reut , Shomron Noam 
Published: February 2025

Abstract
Circulating cell-free DNA (cfDNA) is a powerful diagnostics tool that is widely studied in the context of liquid biopsy in oncology and other fields. In obstetrics, maternal plasma cfDNA have already proven its utility, enabling noninvasive prenatal testing (NIPT), which has become a standard for detecting chromosomal aberrations. However, identification of point mutations responsible for monogenic diseases (NIPT-M) remains limited, even when accounting to fragment specific characteristics (i.e. fragmentomics). While genotyping of individual genomes is performed today using deep learning (DL) algorithms, cfDNA-based noninvasive fetal genotyping is performed only using traditional statistical and machine-learning methods. This study introduces the first DL-based framework for cfDNA based genotyping, heralding a significant stride toward genome-wide NIPT-M. Using unique ultra-deep whole genome sequencing (WGS) data, we were motivated to develop an efficient model, especially when compared with current DL methods for WGS. This facilitates the integration of previously overlooked levels of information, encompassing DNA nucleotides, fragments, mutation regions, samples, and familial traits. Employing this novel approach, we surpass the performance of existing methodologies, successfully detecting three deleterious mutations, and allowing for NIPT-M as early as the 7th week of gestation. Our proposed approach brings genome-wide NIPT for all mutation types closer to clinical feasibility, enabling families and healthcare providers to make well-informed decisions and alleviating the anxieties and uncertainties associated with pregnancy.
Multiply robust difference-in-differences estimation of causal effect curves for continuous exposures
Authors: Hettinger Gary , Lee Youjin , Mitra Nandita 
Published: February 2025

ABSTRACT
Researchers commonly use difference-in-differences (DiD) designs to evaluate public policy interventions. While methods exist for estimating effects in the context of binary interventions, policies often result in varied exposures across regions implementing the policy. Yet, existing approaches for incorporating continuous exposures face substantial limitations in addressing confounding variables associated with intervention status, exposure levels, and outcome trends. These limitations significantly constrain policymakers’ ability to fully comprehend policy impacts and design future interventions. In this work, we propose new estimators for causal effect curves within the DiD framework, accounting for multiple sources of confounding. Our approach accommodates misspecification of a subset of intervention, exposure, and outcome models while avoiding any parametric assumptions on the effect curve. We present the statistical properties of the proposed methods and illustrate their application through simulations and a study investigating the heterogeneous effects of a nutritional excise tax under different levels of accessibility to cross-border shopping.
zk-DCIAExchange: SGX protected fair exchange with distributed zero knowledge proof for data confidentiality and authentication
Authors: Zhan Jing , Li Bo , Zhao Jiang , Zhao Yong 
Published: February 2025

Abstract
Blockchain-based data transaction protocols augmented with zero-knowledge proofs offer fairness to the participants, yet they encounter challenges pertaining to both security and efficiency. We propose the zk-DSTARK, a zk-STARK-based protocol that enables distributed generation of zero-knowledge proofs, significantly reducing the computational burden. And zk-DSTARK inherits zk-STARK’s feature of single proof generation for multiple uses, improving the efficiency of successive transactions. Furthermore, we propose a fair exchange system named zk-DCIAExchange for off-chain verification, which is based on zk-DSTARK and intel software guard extensions (SGX). This system not only minimizes on-chain overhead but also ensures the security and fairness of the transaction. Experimental results show that, in continuous transactions scenarios, the time overhead for subsequent transactions is diminished by 99.9% compared to the first transaction; compared to zero knowledge contingent payment (ZKCSP), our scheme achieves a remarkable 92% reduction in time overhead, and a 26.3% reduction when compared to FairSwap; with 32 distributed nodes and a trace length of 216, the proof generation time is reduced by ~85.45%; the additional verification time introduced by the SGX is ~0.45 s, which is deemed acceptable, and the on-chain verification overhead is reduced by ~7.2% compared to the ZKCSP and ~54.4% compared to FairSwap.
Postoperative atrioventricular block after surgery for congenital heart disease: incidence, recovery, and risks
Authors: Kruse Kristin , Matsubara Muneaki , Schaeffer Thibault , Palm Jonas , Klawonn Frank , Osawa Takuya , Niedermaier Carolin , Heinisch Paul Philipp , Piber Nicole , Balling Gunter , Hager Alfred , Ewert Peter , Hörer Jürgen , Ono Masamichi 
Published: February 2025

Abstract

OBJECTIVES
We aimed to determine the incidence of postoperative complete atrioventricular block, the time to recovery or permanent pacemaker implantation, and the predictors for postoperative atrioventricular block after congenital heart surgery.

METHODS
Patients who underwent open heart surgery from January 2001 to January 2024 were analyzed and predictors of atrioventricular block were identified using a logistic regression model.

RESULTS
Among 9765 congenital heart surgeries, 333 (3.4%) were complicated by atrioventricular block, and 193 patients (1.9%) underwent permanent pacemaker implantation. The highest rates of atrioventricular block were found in patients who underwent repair of congenitally corrected transposition of the great arteries (27.3%), followed by Konno procedure (20.0%), and mitral valve replacement (16.0%), and arterial switch with closure of ventricular septal defect and arch repair (15.0%). In 134 (1.4%) patients with transient atrioventricular block, the median time to resolution was 4 days (interquartile ranges: 2-8 days). After 7 postoperative days, 75% had resolved, and after 12 postoperative days, 90% had resolved. Risk factors for the development of atrioventricular block were older age at operation (odds ratio: 1.012, p = 0.001), preoperative endocarditis (2.422, p &lt; 0.001), longer aortic cross-clamp time (1.018, p &lt; 0.001), and high-risk procedures (1.397, p = 0.012).

CONCLUSIONS
Postoperative atrioventricular block is not rare after congenital heart surgery, with more than half of them needing permanent pacemaker implantation. Older age at operation, preoperative endocarditis, longer aortic cross-clamp time, and high-risk procedures were risks for the development of atrioventricular block. Pacemaker implantation should be delayed to the 12th postoperative day, when 90% of transient blocks have resolved.
Evoked delayed potential ablation for post-myocardial infarction ventricular tachycardia: results from a large prospective multicentre study
Authors: de Riva Marta , Evertz Reinder , Lukac Peter , Dekker Lukas R C , Blaauw Yuri , ter Bekke Rachel M A , Kimura Yoshitaka , Beukema Rypko J , Ouss Alexandre , Mulder Bart A , Vernooy Kevin , Wijnmaalen Adrianus P , Zeppenfeld Katja 
Published: February 2025

Abstract

Aims
The optimal substrate ablation approach for post-myocardial infarction (MI) ventricular tachycardia (VT) is unknown. Proposed ablation targets are prone to individual interpretation making the ablation outcome potentially operator dependent. Evoked delayed potentials (EDPs) are a well-defined target. Evoked delayed potential ablation was effective in preventing post-MI VT recurrence in a prior study. The aims of this study were to assess long-term outcomes of EDP ablation in a large multicentre cohort of post-MI patients and to compare ablation outcomes between centres with and without prior experience in EDP ablation.

Methods and results
Patients with post-MI VT undergoing ablation in one centre performing EDP ablation since 2013 and five centres without prior experience in EDP ablation were prospectively included. A uniform mapping protocol including right ventricular extra-stimulation aiming to EDP identification was followed. Ablation endpoints were EDP elimination and VT non-inducibility. Patients were followed for VT recurrence, mortality, heart transplant, and left ventricular assist device implantation. In total, 130 patients were included. The protocol was successfully performed in 99%, and in 94%, EDPs were identified and ablated. In total, 78% of patients were rendered non-inducible. Ventricular tachycardia-free survival was 78% [95% confidence interval (CI) 71–85] and 71% (95% CI 63–80) at 6 and 12 months, respectively. No difference in VT-free survival was observed among centres with and without prior experience in EPD ablation.

Conclusion
In a large multicentre prospective cohort of patients with post-MI VT, EDP ablation resulted in good long-term outcomes. Importantly, VT recurrence rates did not differ among centres with and without prior experience in EDP ablation, indicating that this approach can be easily reproduced by operators previously not familiar with the technique.
Decreased METTL3 in atrial myocytes promotes atrial fibrillation
Authors: Shi Jian , Zhu Xi-Yu , Yu Rong-Huang , Liu Wen-Xue , Yang Jie , Tang Lu , Kong Chui-Yu , Luo Han-Qing , Chen Fen , Xie Wen-Sen , Fu Jia-Lei , Wang Jing-Jie , Zhou Qian , Zhou Qing , Wang Dong-Jin 
Published: February 2025

Abstract

Aims
Methyltransferase like 3 (METTL3) plays a crucial role in cardiovascular diseases, but its involvement in atrial fibrillation (AF) remains unclear. The study aims to explore the relationship between METTL3 and AF in atrial myocytes.

Methods and results
The protein level of METTL3 was evaluated in left atrial appendages (LAAs) from patients with persistent AF and in experimental AF models. cAMP-responsive element modulator (CREM) transgenic mice and CaCl2-acetylcholine (ACh)-injected mice were used as AF mice models. Methyltransferase like 3 was globally and atrial conditionally deleted in vivo to assess its role in AF. Confocal fluorescence microscopy was employed to examine calcium handling in atrial myocytes. Methylated RNA immunoprecipitation sequencing was performed to identify the downstream target genes of METTL3. Methyltransferase like 3 protein and RNA N6-methyladenosine (m6A) modification levels were significantly reduced in the LAAs of patients with AF and experimental AF models. Genetic inhibition of METTL3 promoted the development of AF in CREM transgenic mice and CaCl2-ACh-injected mice. Knockdown of METTL3 in atrial myocytes resulted in enhanced calcium handling. Reduced METTL3 levels increased SR Ca2+-ATPase Type 2a activity by up-regulating protocadherin gamma subfamily A, 10. Decreased METTL3 protein in atrial myocytes was attributed to down-regulation of cAMP-responsive element-binding protein 1/ubiquitin-specific peptidase 9 X-linked axis.

Conclusion
Our study established the pathophysiological role of METTL3 involved in the development of AF and provided a potential mechanism-based target for its treatment.
Draft genome of the endemic alpine ground beetle Carabus (Platycarabus) depressus (Coleoptera: Carabidae) from long-read sequencing of a frozen archived specimen
Authors: Gauthier Jérémy , Cardenas Cody Raul , Nari Matilde , Gillett Conrad P D T , Toussaint Emmanuel F A 
Published: February 2025

Abstract
The rapid advancement of genomic technologies has enabled the production of highly contiguous reference genomes for non-model organisms. However, these methods often require exceptionally fresh material containing unfragmented high molecular weight nucleic acids. Researchers who preserve field-collected specimens in ethanol at ambient temperatures, prior to transferring them to long-term frozen archives, face challenges in applying advanced genomic approaches due to DNA and RNA fragmentation under suboptimal preservation conditions. To explore the potential of such preserved specimens as sources of reference genomes, we utilized Nanopore MinION technology to generate genomic data from a frozen archived specimen of the endemic alpine ground beetle Carabus (Platycarabus) depressus. Using a rapid in-house protocol for high molecular weight DNA extraction, followed by sequencing on a single flow cell, we produced 8.75 million raw reads with an N50 of 2.8 Kb. The resulting assembly achieved remarkable completeness, recovering up to 98% of BUSCO genes, despite a moderate N50 of 945 Kb. This genome is only the second available for the taxonomically diverse genus Carabus and highlights the feasibility of performing short-to-long-read sequencing from frozen archived specimens commonly housed in natural history collections. These findings open new avenues for advancing non-model organism genomics and its downstream applications.
Racial-Ethnic Differences in Care Networks of Older Adults: Empirical Exploration of Possible Explanations
Authors: Lin Zhiyong 
Published: February 2025

Abstract

Objectives
Previous research on eldercare among minority populations often highlights the role of values, beliefs, and social expectations, placing greater emphasis on ideational factors than on sociostructural and health factors in explaining racial-ethnic differences in care arrangements. This study aims to describe the extent to which care received by older adults varies by race-ethnicity and to explore possible explanations for these variations using the behavioral model of health care use.

Methods
Data were sourced from the 2018 National Health and Aging Trends Study (NHATS), a nationally representative survey of Medicare beneficiaries aged 68 and older. Latent class analyses were used to develop a care network typology with combinations of care from different sources. Multinomial regression models assessed various predisposing, enabling, and need factors associated with racial-ethnic differences in the distribution of constructed care network types. Formal mediation analysis tested potential mediators of these differences.

Results
Black and Hispanic older adults tended to receive care from children and extended kin caregivers, while White older adults were more likely to receive care from their spouses and perform self-care with assistive technologies. Mediation analyses revealed that racial-ethnic differences in care networks were primarily attributable to enabling factors, including family configurations, social networks, and socioeconomic status. Limited evidence was found for the roles of predisposing factors, measured by care preferences, and need factors, measured by health conditions, in explaining these differences.

Discussion
The findings highlight the need for more research and policy interventions to address the diverse challenges faced by socially disadvantaged older adults.
LRP8 inhibits bladder cancer cell ferroptosis by activating the Wnt/β-catenin-SCD1 positive feedback loop
Authors: Zhao Yong , Shi Guohong , Huang Xiang , Zhang Zhongyuan , Liao Kaijun , Xiong Hao , Feng Zhiqiang , Mao Shihui , Zhang Xu 
Published: February 2025

Abstract

Background
Advanced bladder cancer (bc) patients often have poor prognoses due to issues such as recurrence and drug resistance. The discovery of ferroptosis has opened new avenues for bc treatment; however, the specific regulatory mechanisms remain to be explored. This study aimed to investigate the mechanisms influencing ferroptosis in bc cells, with a particular focus on the role of low-density lipoprotein receptor-related protein 8 (LRP8).

Methods
We utilized reverse transcription-quantitative polymerase chain reaction and western blot to assess the expression of LRP8 in bc cells, activation of the Wnt/β-catenin signaling pathway, and the expression of genes related to fatty acid synthesis. We measured changes in ferroptosis levels by evaluating mitochondrial membrane potential, Fe2+, malondialdehyde, and reactive oxygen species levels. A xenograft mouse model was employed to validate the impact of LRP8 on bc progression.

Results
Cell experiments demonstrated a significant upregulation of LRP8 expression in bc cells. Knockdown of LRP8 induced ferroptosis in bc cells, a process directly triggered by the inhibition of the Wnt/β-catenin signaling pathway. Activation of the Wnt/β-catenin signaling pathway mediated by LRP8 upregulated the expression of stearoyl-CoA desaturase 1 (SCD1), subsequently leading to the suppression of ferroptosis. In vivo experiments indicated that LRP8 knockdown significantly impaired bc growth, accompanied by inhibition of the Wnt/β-catenin-SCD1 axis.

Conclusion
LRP8 mediates the synthesis of monounsaturated fatty acids through the Wnt/β-catenin-SCD1 positive feedback loop, thereby inhibiting ferroptosis in bc cells. These findings provide a promising target for the regulation of ferroptosis in bc cells.
Limits of Random Motzkin Paths with KPZ Related Asymptotics
Authors: Bryc Włodzimierz , Kuznetsov Alexey , Wesołowski Jacek 
Published: February 2025

Abstract
We study Motzkin paths of length $L$ with general weights on the edges and endpoints. We investigate the limit behavior of the initial and final segments of the random Motzkin path viewed as a pair of processes starting from each of the two endpoints as $L$ becomes large. We then study macroscopic limits of the resulting processes, where in two different regimes we obtain Markov processes that appeared in the description of the stationary measure for the KPZ equation on the half-line and of conjectural stationary measure of the hypothetical KPZ fixed point on the half-line. Our results rely on the behavior of the Al-Salam–Chihara polynomials in the neighbourhood of the right end of their orthogonality interval and on the limiting properties of the $q$-Pochhammer and $q$-Gamma functions as $q\nearrow 1$.
Segal K-theory of vector spaces with an automorphism
Authors: Bianchi Andrea , Kranhold Florian 
Published: February 2025

Abstract
We describe the Segal $K$-theory of the symmetric monoidal category of finite-dimensional vector spaces over a field $\mathbb{F}$ together with an automorphism, or, equivalently, the group-completion of the $E_\infty $-algebra of maps from $S^{1}$ to the disjoint union of classifying spaces $\mathrm{B}\mathrm{GL}_{d}(\mathbb{F})$, in terms of the $K$-theory of finite field extensions of $\mathbb{F}$. A key ingredient for this is a computation of the Segal $K$-theory of the category of finite-dimensional vector spaces with a nilpotent endomorphism. We also discuss the topological cases of $\mathbb{F}=\mathbb{C},\mathbb{R}$.