bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trait-Based Segmentation for Mobile Personalization and Privacy Concerns: A Cluster Analysis Based on Need for Cognitive Closure
Authors: Quach Xuan 
Published: September 2023

<p>This research explores the connection between consumers’ characteristics and their perceptions of personalized preferences and privacy concerns. From a sample of 285 participants and using a cluster analysis technique, I segment consumers based on their need for cognitive closure. Need for cognitive closure contains five dimensions (preference for order, preference for predictability, discomfort with ambiguity, close-mindedness, and decisiveness) that characterizes one’s desire for firm answers and predictability. Three cluster groups, “Equivocal Users”, “Structured Users”, and “Eclectic Users” were identified and supplementary analyses revealed differences in their mobile personalization and preference for information privacy. The findings provide key insights and recommendation for marketers and retail managers to implement appropriate personalization strategies for these distinct target groups </p>
Did the STOCK Act Impact the Performance, Risk, and Flow of Hedge Funds?
Authors: Shah Meet 
Published: September 2023

<p>This research examines hedge funds’ performance, risk, and flow before and after the implementation of the Stop Trading on Congressional Knowledge (STOCK) Act. This study finds significant differences before and after the implementation of the STOCK Act. The results for the entire sample period indicate that hedge funds suffered lower-alpha, standard deviation, and idiosyncratic risk after the implementation of the STOCK Act. Consistent with other studies, the findings suggest that private, confidential information was likely passed down from congress members to the hedge fund managers through intermediary agents. Furthermore, the results indicate mixed evidence of the STOCK Act’s impact on hedge funds’ flow for most investment categories, which points to the direction that top-level hedge funds received more significant capital inflows. </p>
Foreign Direct Investment Inflows into China
Authors: Zhao Yunlong 
Published: September 2023

<p>Foreign direct investment (FDI) has shown itself to be a strong catalyst in economic development. This paper attempts to research what factors affect the Foreign Direct Investment (FDI) inflows to China from 2002 to 2018, making China a great success in economic development. This paper presents a multiple linear regression model methodology using monthly data spans from 2002 to 2018 to evaluate and analyze. This process will include gathering data from various secondary sources and a set of quantitative research methods. The multiple linear regression model hypothesizes there is a relationship between Foreign Direct Investment and explanatory factors: Consumer Price Index Growth, Producer Price Index Growth, Economic Climate coincident Indicator, Official Exchange Rate to USD, Net Exports, and Economic Policy Uncertainty. The result indicates that the CPI growth rate, Net Exports and Economic Policy Uncertainty have significant positive relationships with China’s FDI inflows. Whereas the PPI growth rate and ECI negatively correlate with the response variable. </p>
The Relationship of Trunk Control with Lower Extremity Sense, Balance, and Walking in Individuals with Stroke
Authors: EKMEKÇİOĞLU Zehra , KATIRCI KIRMACI Zekiye İpek , ERGUN Nevin 
Published: September 2023

Objective: This study was conducted to investigate the relationship between trunk control and lower extremity sense, balance and gait in stroke individuals.
Methods: Thirty subacute and chronic stroke patients were included in the study (mean age 52. 2 14.4 years). Trunk Impairment Scale (TIS) and Turkish version of Postural Assessment Scale for Stroke Patients (PASS-T) was used for evaluating the body control, and Tinetti Balance Test (TBT) was used for evaluating balance. Tinetti Gait Test (TGT) and Ten Meter Walking Test (TMWT) were applied for evaluating walking. The light touch sense and proprioception, Fugl-Meyer Assessment of Sensorimotor Function (FMASF) for lower extremity were used. Furthermore, neglect, plantar pressure sense and stereognosis for lower extremity were evaluated.
Results: There was a significant positively strong correlation between TIS and TBT, TGT and FMSMFT, and negatively strong correlation between TIS and TMWT (p
Hyaluronic Acid-Curcumin Complex Triggers Apoptotic Pathway in Breast Cancer Cells via CD44 Receptors
Authors: MOKHBERİOSKOUEİ Ziba , BİÇİM Gökhan , YİLMAZ Ayse , YALÇIN A. Suha 
Published: September 2023

Objective: Curcumin (CUR) was modified with hyaluronic acid (HA) to increase its water solubility and bioavailability. Our aim was to increase the uptake of CUR into the cells that express CD44 receptors and to compare the cellular effects in two different human breast carcinoma cells, MCF-7 and MDA-MB-231.
Methods: Hyaluronic acid-curcumin complex (HA-CUR) was synthesized and characterized.
MCF-7 and MDA-MB-231 cells were grown under appropriate conditions and the effect of CUR and HA-CUR on cell viability was determined. Apoptosis levels of cells after treatment with CUR and HA-CUR were also measured. CD44 receptor levels of both cells were compared and then apoptosis levels were measured in MDA-MB-231 cells after saturation of CD 44 receptors with HA. In both cells expression of caspase-9 and PARP was analyzed to confirm apoptosis.
Results: In MCF-7 cells, the percentage apoptosis level of the CUR group was slightly lower than the HA-CUR group. In MDA-MB-231 cells, no statistically significant difference was found in the CUR group compared to the control group, but the apoptosis level of the HA-CUR group was higher than the control group. CD44 receptor levels were higher in MDA-MB-231 cells compared to MCF-7 cells. Blocking the CD44 receptors reversed the apoptotic effect of HA-CUR in MDA-MB-231 cells. Both CUR and HA-CUR had apoptotic effects in MCF-7 and MDA-MB-231 cells.
Conclusion: Conjugation of CUR with HA, which is specific for CD44 receptors aids, in its entry to target cells making it a powerful agent for targeted cancer therapy.
The Effect of Mental Health on Health-Related Quality of Life in Adolescents
Authors: AK Tuba , İLHAN Nesrin 
Published: September 2023

Objective: The aim of this study was to determine the effect of mental health on health-related quality of life in adolescents.
Methods: This cross-sectional study was conducted among 1188 students studying in a public high school in Istanbul, Turkey. Data were collected using the General Health Questionnaire (GHQ-12) and the Turkish Generic Health-Related Quality of Life Questionnaire for adolescents (Kiddo-KINDL). Descriptive statistics, correlation analysis and multiple regression analysis were used in the analysis.
Results: The mean age of the adolescents was 16.61±1.17; 56.6% were female. This study shows that mental health was a negatively significantly related to all subscales of health-related quality of life (physical wellbeing, emotional wellbeing, self-esteem, family, friends, school) of adolescents (p
Determining the Image of Nursing Profession in the Society During Covid-19 Pandemia Process
Authors: YILMAZ GÜVEN Durdane , ŞENER Şenay 
Published: September 2023

Objective: This study aimed to descriptively determine the image of the nursing profession in the society during the Covid-19 pandemic process.
Methods: The study was carried out in a district between November 2020 and February 2021. The sample of the study consisted of 1285 individuals. While collecting the data, a “Questionnaire Form” containing personal characteristics and “Image Scale for Nursing Profession” were used. Data were collected by snowball sampling method. The data were collected through an online survey.
Results: The mean score of the participants’ Image Scale for Nursing Profession was found to be 150.68 ± 9.75. It was determined that the subdimensions of the scale, the professional qualification sub-dimension, had the highest mean score of 45.80 ± 4.45, and the other appearance sub-dimension had the lowest mean score of 11.10 ± 2.73. A significant difference was determined between the Image Scale for Nursing Profession and gender, profession, and the status of having the received care from nurses before (p
The instantly blocking-based fluorescent immunochromatographic assay for the detection of SARS-CoV-2 neutralizing antibody
Authors: Li Yizhe , He Jinyong , Zhang Ying , Liang Dan , Zhang Jiaqi , Ji Ruili , Wu Yue , Su Zejie , Ke Changwen , Xu Ning , Tang Yong , Xu Jianhua 
Published: September 2023

IntroductionAt present, there is an urgent need for the rapid and accurate detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies (NAbs) to evaluate the ability of the human body to resist coronavirus disease 2019 (COVID-19) after infection or vaccination. The current gold standard for neutralizing antibody detection is the conventional virus neutralization test (cVNT), which requires live pathogens and biosafety level-3 (BSL-3) laboratories, making it difficult for this method to meet the requirements of large-scale routine detection. Therefore, this study established a time-resolved fluorescence-blocking lateral flow immunochromatographic assay (TRF-BLFIA) that enables accurate, rapid quantification of NAbs in subjects.MethodsThis assay utilizes the characteristic that SARS-CoV-2 neutralizing antibody can specifically block the binding of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and angiotensin-converting enzyme 2 (ACE2) to rapidly detect the content of neutralizing antibody in COVID-19-infected patients and vaccine recipients.ResultsWhen 356 samples of vaccine recipients were measured, the coincidence rate between this method and cVNT was 88.76%, which was higher than the coincidence rate of 76.97% between cVNT and a conventional chemiluminescence immunoassay detecting overall binding anti-Spike-IgG. More importantly, this assay does not need to be carried out in BSL-2 or 3 laboratories.DiscussionTherefore, this product can detect NAbs in COVID-19 patients and provide a reference for the prognosis and outcome of patients. Simultaneously, it can also be applied to large-scale detection to better meet the needs of neutralizing antibody detection after vaccination, making it an effective tool to evaluate the immunoprotective effect of COVID-19 vaccines.
Experimental and in silico evaluation of Carthamus tinctorius L. oil emulgel: a promising treatment for bacterial skin infections
Authors: Saeed Javaria , Hussain Shah Syed Nisar , Javed Hina , Aslam Asma , Ali Anam , Siddique Farhan , Zahra Tahreem , Bin Jardan Yousef A. , Wondmie Gezahign Fentahun , Nafidi Hiba-Allah , Bourhia Mohammed 
Published: September 2023

PurposeThe current study aimed to develop a topical herbal emulgel containingCarthamus tinctoriusL. (CT) oil extract, which has been scientifically proven for its antibacterial and antioxidant activities for the ailment of bacterial skin infections.MethodThe CT emulgel was formulated by response surface methodology (RSM) and was evaluated by various parameters like extrudability, spreadability, pH, viscosity, and antibacterial and antioxidant activities. Molecular docking was also performed using AutoDock.ResultsAmong all formulated CT emulgels, F9 and F8 were optimized. Optimized formulations had shown good spreadability and extrudability characteristics. Sample F8 had % inhibition of 42.131 ± 0.335, 56.720 ± 0.222, and 72.440 ± 0.335 at different concentrations. Sample F9 had % inhibition of 26.312 ± 0.280, 32.461 ± 0.328, and 42.762 ± 0.398 at concentrations of 250 µg/ml, 500 µg/ml, and 1,000 µg/ml, respectively, which shows that both samples F8 and F9 have significant antioxidant potential. Optimized CT emulgels F8 and F9 had significant antibacterial activity againstStaphylococcus aureusandEscherichia coliat p-value = 0.00, the Emulgel-F8 shows zone of inhibition of 24 mm forE-coliand 19 mm forS-aureus. Emulgel-F9 shows zone of inhibition of 22 mm forE-coliand 15 mm forS-aureuswhile pure CT- Oil extract shows zone of inhibition of 25 mm forE-coliand 20 mm forS-aureusand ciprofloxacin used as standard shows 36mm zone of inhibition against bothE-coliandS-aureus. The comparative investigation through molecular docking binding affinities and interactions of ligands with various target proteins provides insights into the molecular processes behind ligand binding and may have significance for drug discovery and design for the current study.ConclusionThe current study suggests thatC. tinctoriusL.-based emulgel has good antioxidant and antibacterial activities againstE. colifor the treatment of bacterial skin infections.
Assessment of left ventricular function in patients with type 2 diabetes mellitus by non-invasive myocardial work
Authors: Cao Wenjia , Deng Yan , Lv Linyi , Liu Xuebing , Luo Anguo , Yin Lixue , Li Zhaohuan 
Published: September 2023

BackgroundDiabetes mellitus (DM) is a chronic disease that poses a serious risk of cardiovascular diseases. Therefore, early detection of impaired cardiac function with non-invasive myocardial imaging is critical for improving the prognosis of patients with DM.PurposeThis study aimed to assess the left ventricular (LV) function in patients with type 2 diabetes mellitus (T2DM) by non-invasive myocardial work technique.Materials and methodsIn all, 67 patients with T2DM and 28 healthy controls were included and divided into a DM group and a control group. Two-dimensional dynamic images of apical three-chamber view, apical two-chamber view, and apical four-chamber view were collected from all subjects, consisting of at least three cardiac cycles. LV myocardial strain parameters, including global longitudinal strain (GLS) and peak strain dispersion (PSD), as well as myocardial work parameters, including global constructive work (GCW), global wasted work (GWW), global work index (GWI), and global work efficiency (GWE), were obtained and analyzed.ResultsA total of 15 subjects were randomly selected to assess intra-observer and inter-observer consistency of myocardial work parameters and strain parameters, which showed excellent results (intra-class correlation coefficients: 0.856 - 0.983, P&lt;0.001). Compared with the control group, the DM group showed significantly higher PSD (37.59 ± 17.18 ms vs. 27.72 ± 13.52 ms, P&lt;0.05) and GWW (63.98 ± 43.63 mmHg% vs. 39.28 ± 25.67 mmHg%, P&lt;0.05), and lower GWE (96.38 ± 2.02% vs. 97.72 ± 0.98%, P&lt;0.001). Furthermore, the PSD was positively correlated with GWW (r = 0.565, P&lt;0.001) and negatively correlated with GWE (r = -0.569, P&lt;0.001).ConclusionUncoordinated LV myocardial strain, higher GWW, and lower GWE in patients with T2DM may serve as indicators for the early assessment of cardiac impairment in T2DM.
Operation strategies of capital-constrained small and medium-sized enterprises based on blockchain technology
Authors: Huang Zuqing , Wu Zhen , Cao Bingbing 
Published: September 2023

Introduction: In reality, due to the low credit rating of small and medium-sized enterprises (SMEs), it is difficult for them to obtain sufficient financing from a single financier. This paper considers a dual-channel supply chain consisting of a capital-constrained manufacturer, an e-commerce platform (ECP), a third-party logistics company (3PL) and consumers. There are two innovations in this paper: the manufacturer obtains sufficient production funds through hybrid financing of the ECP and 3PL, and consumers want to know product information and compare prices. The contributions of this paper are to investigate new applications of blockchain in both hybrid financing and meeting consumer information search needs.Methodology: We discuss the operation and pricing decisions of supply chain in two scenarios. These two scenarios are without adopting blockchain (N) and with adopting blockchain (B). Then, we compare the equilibrium decisions in two scenarios.Results: The results show that the supply chain will adopt blockchain when certain conditions are met. The initial adoption of blockchain is bad for the ECP and 3PL. Further, we find that with the increase of financing ratio, the optimal financing interest rate of the ECP decreases, while the optimal financing interest rate of the 3PL increases.Discussion: The numerical analysis shows that the adoption of blockchain can be more profitable when the cost of information search is high.Management insights: In order to achieve supply chain coordination, the manufacturer should give subsidies the ECP and 3PL.
Factors influencing immunogenicity and safety of SARS-CoV-2 vaccine in liver transplantation recipients: a systematic review and meta-analysis
Authors: Luo Xinyi , Lessomo Fabrice Yves Ndjana , Yu Zhimin , Xie Yong 
Published: September 2023

BackgroundThis review summarizes the factors influencing the efficacy and safety of the COVID-19 vaccine in LTR through meta-analysis, hoping to provide strategies for vaccine use.MethodsElectronic databases were screened for studies on mRNA vaccines in LTR. The primary outcome was the pooled seroconversion rate, and the secondary outcome was the incidence of adverse events+breakthrough infections. Subgroup analyses were made based on BMI, associated comorbidities, presence of baseline leukopenia, time since transplant, and drugs used.ResultIn total, 31 articles got included. The pooled seroconversion rate after at least two doses of SARS-CoV-2 vaccination was 72% (95% CI [0.52-0.91). With significant heterogeneity among studies I2 = 99.9%, the seroconversion rate was about 72% (95%CI [0.66-0.75]), from the studies reporting two doses of vaccine slightly higher around 75%(95%CI [0.29-1.22]) from studies reporting three doses. The pooled seroconversion rate within the lower to normal BMI group was 74% (95% CI [0.22-1.27], Pi=0.005) against 67% (95% CI [0.52-0.81], Pi=0.000) in the high BMI group. The pooled seroconversion rate in the ‘‘positive leukopenia’’ group was the lowest, 59%. Leukopenia could influence the vaccine seroconversion rate in LTR. From the time since transplant analysis after setting seven years as cut off point, the pooled seroconversion rate after at least two doses of COVID-19 vaccination was 53% (95% CI [0.18-0.83], P=0.003, I2 = 99.6%) in &lt;7years group and 83% (95% CI [0.76-0.90], P=0.000 I2 = 95.7%) in &gt; 7years group. The only time since transplantation had reached statistical significance to be considered a risk factor predictor of poor serological response (OR=1.27 95%CI [1.03-1.55], P=0.024). The breakthrough infection rate after vaccination was very low2% (95% CI 0.01-0.03, I2 = 63.0%), and the overall incidence of adverse events, which included mainly pain at the injection site and fatigue, was 18% (95%CI [0.11-0.25], I2 = 98.6%, Pi=0.000).ConclusionThe seroconversion rate in LTR vaccinated with at least two doses of mRNA COVID-19 vaccine could be significantly affected by the vaccine type, immunosuppressant used, BMI, leukopenia, associated comorbidities, and time since transplantation. Nevertheless, booster doses are still recommended for LTR.
A nomogram to predict in-hospital mortality of gastrointestinal bleeding patients in the intensive care unit
Authors: Zhang Xueyan , Ni Jianfang , Zhang Hongwei , Diao Mengyuan 
Published: September 2023

BackgroundGastrointestinal bleeding (GIB) is a common condition in clinical practice, and predictive models for patients with GIB have been developed. However, assessments of in-hospital mortality due to GIB in the intensive care unit (ICU), especially in critically ill patients, are still lacking. This study was designed to screen out independent predictive factors affecting in-hospital mortality and thus establish a predictive model for clinical use.MethodsThis retrospective study included 1,442 patients with GIB who had been admitted to the ICU. They were selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) 1.0 database and divided into a training group and a validation group in a ratio of 7:3. The main outcome measure was in-hospital mortality. Least absolute shrinkage and section operator (LASSO) regression was used to screen out independent predictors and create a nomogram.ResultsLASSO regression picked out nine independent predictors: heart rate (HR), activated partial thromboplastin time (aPTT), acute physiology score III (APSIII), sequential organ failure assessment (SOFA), cerebrovascular disease, acute kidney injury (AKI), norepinephrine, vasopressin, and dopamine. Our model proved to have excellent predictive value with regard to in-hospital mortality (the area under the receiver operating characteristic curve was 0.906 and 0.881 in the training and validation groups, respectively), as well as a good outcome on a decision curve analysis to assess net benefit.ConclusionOur model effectively predicts in-hospital mortality in patients with GIB, indicating that it may prove to be a valuable tool in future clinical practice.
Lactational and geographical variation in the concentration of six oligosaccharides in Chinese breast milk: a multicenter study over 13 months postpartum
Authors: Liu Shuang , Mao Yingyi , Wang Jin , Tian Fang , Hill David R. , Xiong Xiaoying , Li Xiang , Zhao Yanrong , Wang Shuo 
Published: September 2023

IntroductionUnderstanding the variations of oligosaccharide in breast milk contribute to better study how human milk oligosaccharides (HMOs) play a role in health-promoting benefits in infants.MethodsSix abundant HMOs, 2’-fucosyllactose (2’-FL), 3-fucosyllactose (3-FL), Lacto-N-tetraose (LNT), Lacto-N-neotetraose (LNnT), 3’-sialyllactose (3’-SL) and 6’-sialyllactose (6’-SL), in breast milk collected at 0–5 days, 10–15 days, 40–45 days, 200–240 days, and 300–400 days postpartum from six locations across China were analyzed using high-performance anion-exchange chromatography-pulsed amperometric detector.ResultsThe concentration of individual HMO fluctuated dynamically during lactational stages. The median ranges of 2’-FL, 3-FL, LNT, LNnT, 3’-SL, and 6’-SL across the five lactational stages were 935–2865 mg/L, 206–1325 mg/L, 300–1473 mg/L, 32–317 mg/L, 106–228 mg/L, and 20–616 mg/L, respectively. The prominent variation was observed in the content of 6’-SL, which demonstrates a pattern of initial increase followed by a subsequent decrease. Among the five lactational stages, the transitional milk has the highest concentration, which was 31 times greater than the concentration in mature milk at 300–400 days postpartum, where the content is the lowest. Geographical location also influenced the content of HMOs. LNT and LNnT were the highest in mature milk of mothers from Lanzhou among the six sites at 40–240 days postpartum. Breast milks were categorized into two groups base on the abundance of 2’-FL (high and low). There was no significant difference in the proportions of high and low 2’-FL phenotypes among the six sites, and the percentages of high and low 2’-FL phenotypes were 79% and 21%, respectively, across all sites in China.DiscussionThis study provided a comprehensive dataset on 6 HMOs concentrations in Chinese breast milk during the extended postpartum period across a wide geographic range and stratified by high and low 2’-FL phenotypes.