bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cholangiocarcinoma: a current literature review.
Authors: Pérez Ramírez A , Ruz Zafra P , Pérez Estrada C , Sánchez Torrijos Y 
Published: March 2023

Resumen

El colangiocarcinoma incluye un grupo muy heterogéneo de neoplasias que pueden surgir de cualquier punto del sistema biliar. Según el punto del árbol biliar donde se originen se pueden clasificar en intrahepático, perihiliar y distal. Generalmente presentan un mal pronóstico y la mayoría se diagnostican en etapas avanzadas de la enfermedad. Su incidencia a nivel mundial es variable según la prevalencia de sus diferentes factores de riesgo así como el subtipo de colangiocarcinoma.

Para el diagnóstico existen distintas pruebas de imagen como la ecografía, ecografía con contraste, tomografía computerizada y resonancia magnética, siendo esta última la técnica gold standard en los últimos años. La biopsia representa el pilar fundamental en el diagnóstico, sin embargo, ésta no siempre es posible ni imprescindible. Para la estadificación se utiliza el sistema TNM, existiendo clasificaciones independientes para cada subtipo.

La resección quirúrgica es la única opción potencialmente curativa, sin embargo, un alto porcentaje de pacientes se diagnostica en etapas avanzadas de la enfermedad, cuando el tumor es ya irresecable y la única opción disponible es la quimioterapia paliativa. Tras la cirugía, se recomienda tratamiento quimioterápico adyuvante dado el alto riesgo de recidiva. Se encuentran en marcha ensayos clínicos de inmunoterapia, basada en el perfil genético de cada tipo de colangiocarcinoma, de los que se esperan resultados prometedores.

El trasplante hepático es una opción terapéutica que actualmente solo se considera en el subtipo perihiliar, como excepción al MELD.
EFEKTIFITAS PIJAT BAYI TERHADAP PERKEMBANGAN BAYI (MOTORIK KASAR, MOTORIK HALUS, SOSIAL KEMANDIRIAN DAN BAHASA) PADA BAYI USIA 6-7 BULAN DI DESA DERMAYON KRAMATWATU
Authors: NURSEHA NURSEHA , SUBAGIYO SRI UTAMI 
Published: March 2023

Pendahuluan: Pemberian stimulus yang diberikan sesaat setelah bayi lahir memberikan efek yang sangat penting pada perkembangan kemampuan motorik dan adaptasi sosial di masa perkembangan bayi hingga dewas. Pijat bayi merupakan pengungkapan kasih sayang antara orang tua dengan anak lewat sentuhan pada kulit yang berdampak sangat luar biasa. Tujuan penelitian ini adalah untuk mengetahui efektifitas dari pijat bayi terhadap perkembangan (motoric kasar, motoric halus, social kemandirian dan Bahasa) bayi usia 6-7 bulan. Metode: Penelitian ini merupakan penelitian quasi experiment dengan rancangan non equivalen control group design. Lokasi penelitian akan dilakukan di Puskesmas Kramatwatu dan waktu penelitian dilakukan pada bulan Mei – Juli 2022. Populasi penelitian ini adalah ibu yang mempunyai bayi dengan umur 6 bulan sampai 7 bulan. Adapun teknik pengambilan sampel yang digunakan adalah total populasi. Analisis data dengan menggunakan uji t dengan tingkat kepercayaan 95% dan tingkat kemaknaan (α) 0,05. Hasil dan Pembahasan: Hasil penelitian menunjukan pijat bayi efektif terdapat perkembangan motorik kasar (0,015), Pijat bayi efektif terdapat perkembangan motorik halus (0,025), Pijat bayi efektif terdapat perkembangan sosial kemandirian (0,032), Pijat bayi efektif terdapat perkembangan bahasa (0,019). Kesimpulan: Pijat bayi terbukti efektif terhadap perkembangan motorik kasar, motorik halus, sosial kemandirian, dan bahasa pada bayi usia 6-7 bulan.
HUBUNGAN PERILAKU HIGIENE IBU DAN KEJADIAN DIARE DENGAN KEJADIAN STUNTING PADA BALITA
Authors: KHAIRANI NURUL , EFFENDI SANTOSO UJANG , SURYANI SURYANI 
Published: March 2023

Dampak stunting pada anak bersifat langsung dan jangka panjang yaitu peningkatan morbiditas dan mortalitas, gangguan perkembangan, kapasitas belajar, dan peningkatan risiko infeksi dan penyakit tidak menular. Tujuan penelitian ini adalah untuk mempelajari hubungan perilaku higiene ibu dan kejadian diare dengan kejadian stunting pada balita yang berkunjung ke Posyandu di di wilayah kerja Puskesmas Padang Serai Kota Bengkulu. Jenis penelitian adalah Survei Analitik dengan desain Case Control. Sampel kasus adalah seluruh ibu yang memiliki balita stunting yang berusia 12-59 bulan sebanyak 26 ibu. Sampel kontrol adalah ibu yang memiliki balita tidak stunting yang berusia 12-59 bulan sebanyak 26 ibu. Teknik pengambilan untuk sampel kasus adalah Total Sampling, sedangkan untuk sampel kontrol adalah Purposive Sampling. Data dikumpulkan dengan menggunakan kuesioner dan pengukuran antropometri. Data dianalisis secara univariat dan bivariat. Analisis bivariat menggunakan uji statistik Chi-Square (χ2). Hasil penelitian menunjukkan bahwa 26 ibu (50,0%) memiliki balita yang mengalami kejadian stunting, 43 ibu (82,7%) memiliki perilaku higiene kurang baik, dan 39 ibu (75,0%) memiliki balita yang mengalami kejadian diare. Tidak ada hubungan yang signifikan antara perilaku higiene ibu (p=1,000, OR=1,310) dan kejadian diare (p=1,000, OR=0,814) dengan kejadian stunting. Diharapkan kepada petugas gizi Puskesmas untuk dapat memberikan edukasi kepada ibu balita tentang perilaku higiene yang baik dan pencegahan diare agar kejadian stunting dapat dicegah.
FACIAL NERVE PARALYSIS AND INTUSSUSCEPTION AS CLINICAL PRESENTATIONS OF LYMPHOBLASTIC LYMPHOMA: A RARE PEDIATRIC CASE REPORT
Authors: Musdalipa Musdalipa , Ridha Nadirah Rasyid , Salekede Setia Budi , Angriani Hadia 
Published: March 2023

Lymphoblastic lymphoma (LBL) is a highly aggressive lymphoblast neoplasm due to the presence of clonal hematopoietic stem cell abnormalities of B or T cell origin. LBL represents 30% of pediatric non-Hodgkin's lymphomas. We report a 2-year-11-month-old boy with complaints of a lump in the abdomen and facial paralysis on the left side. weight loss of 3 kg in 3 months, frequent nausea and vomiting, and constipation. On physical examination, the face was not symmetrical on the left and right. palpable mass from the right iliac region to the left iliac, measuring 17.5 x 10 x 5 cm, immobile, rubbery consistency. There is lymphadenopathy right inguinal region et sinistra. Abdominal ultrasound without contrast showed ileocolic intussusception, with histopathological results showing malignant non-Hodgkin's lymphoma. The therapy given was chemotherapy according to the protocol for non-Hodgkin's lymphoma. Facial nerve paralysis and intussusception are rare clinical features of LBL. It is important to consider a differential diagnosis such as LBL in a patient with a lump accompanied by facial nerve paralysis and intussusception. Histopathological and immunohistochemical examination were needed.Keywords: Â Lymphoblastic Lymphoma; Facial Nerve Paralysis; Intussusception
Simulations for Planning Next-generation Exoplanet Radial Velocity Surveys
Authors: Newman Patrick D , Plavchan Peter , Burt Jennifer A. , Teske Johanna , Mamajek Eric E. , Leifer Stephanie , Gaudi B. Scott , Blackwood Gary , Morgan Rhonda 
Published: March 2023

Abstract
Future direct imaging missions similar to the HabEx and LUVOIR mission concepts aim to catalog and characterize Earth-mass analogs around nearby stars. The exoplanet yield of these missions will be dependent on the frequency of Earth-like planets, and potentially the a priori knowledge of which stars specifically host suitable planetary systems. Ground- or space-based radial velocity surveys can potentially perform the pre-selection of targets and assist in the optimization of observation times, as opposed to an uninformed direct imaging survey. In this paper, we present our framework for simulating future radial velocity surveys of nearby stars in support of direct imaging missions. We generate lists of exposure times, observation time-series, and radial velocity time-series given a direct imaging target list. We generate simulated surveys for a proposed set of telescopes and precise radial velocity spectrographs spanning a set of plausible global-network architectures that may be considered for next-generation extremely precise radial velocity surveys. We also develop figures of merit for observation frequency and planet detection sensitivity, and compare these across architectures. From these, we draw conclusions, given our stated assumptions and caveats, to optimize the yield of future radial velocity surveys supporting direct imaging missions. We find that all of our considered surveys obtain sufficient numbers of precise observations to meet the minimum theoretical white noise detection sensitivity for Earth-mass habitable-zone planets. While our detection rates and mass-sensitivity are optimistic, we have margin to explore systematic effects due to stellar activity and correlated noise in future work.
Multi-messenger Approaches to Supermassive Black Hole Binary Detection and Parameter Estimation. II. Optimal Strategies for a Pulsar Timing Array
Authors: Liu Tingting , Cohen Tyler , McGrath Casey , Demorest Paul B. , Vigeland Sarah J. 
Published: March 2023

Abstract
Pulsar timing arrays (PTAs) are Galactic-scale gravitational wave (GW) detectors consisting of precisely timed pulsars distributed across the sky. Within the decade, PTAs are expected to detect nanohertz GWs emitted by close-separation supermassive black hole binaries (SMBHBs), thereby opening up the low-frequency end of the GW spectrum for science. Individual SMBHBs which power active galactic nuclei are also promising multi-messenger sources; they may be identified via theoretically predicted electromagnetic (EM) signatures and be followed up by PTAs for GW observations. In this work, we study the detection and parameter estimation prospects of a PTA which targets EM-selected SMBHBs. Adopting a simulated Galactic millisecond pulsar population, we envisage three different pulsar timing campaigns which observe three mock sources at different sky locations. We find that an all-sky PTA which times the best pulsars is an optimal and feasible approach to observe EM-selected SMBHBs and measure their source parameters to high precision (i.e., comparable to or better than conventional EM measurements). We discuss the implications of our findings in the context of future PTA experiments with the planned Deep Synoptic Array-2000 and the multi-messenger studies of SMBHBs such as the well-known binary candidate OJ 287.
BICEP/Keck. XVI. Characterizing Dust Polarization through Correlations with Neutral Hydrogen
Authors: Ade P. A. R. , Ahmed Z. , Amiri M. , Barkats D. , Thakur R. Basu , Bischoff C. A. , Beck D. , Bock J. J. , Boenish H. , Bullock E. , Buza V. , Cheshire J. R. , Clark S. E. , Connors J. , Cornelison J. , Crumrine M. , Cukierman A. , Denison E. V. , Dierickx M. , Duband L. , Eiben M. , Fatigoni S. , Filippini J. P. , Fliescher S. , Giannakopoulos C. , Goeckner-Wald N. , Goldfinger D. C. , Grayson J. , Grimes P. , Hall G. , Halal G. , Halpern M. , Hand E. , Harrison S. , Henderson S. , Hildebrandt S. R. , Hubmayr J. , Hui H. , Irwin K. D. , Kang J. , Karkare K. S. , Karpel E. , Kefeli S. , Kernasovskiy S. A. , Kovac J. M. , Kuo C. L. , Lau K. , Leitch E. M. , Lennox A. , Megerian K. G. , Minutolo L. , Moncelsi L. , Nakato Y. , Namikawa T. , Nguyen H. T. , O’Brient R. , IV R. W. Ogburn , Palladino S. , Petroff M. A. , Prouve T. , Pryke C. , Racine B. , Reintsema C. D. , Richter S. , Schillaci A. , Schwarz R. , Schmitt B. L. , Sheehy C. D. , Singari B. , Soliman A. , Germaine T. St. , Steinbach B. , Sudiwala R. V. , Teply G. P. , Thompson K. L. , Tolan J. E. , Tucker C. , Turner A. D. , Umiltà C. , Vergès C. , Vieregg A. G. , Wandui A. , Weber A. C. , Wiebe D. V. , Willmert J. , Wong C. L. , Wu W. L. K. , Yang H. , Yoon K. W. , Young E. , Yu C. , Zeng L. , Zhang C. , Zhang S. ,   BICEP/Keck Collaboration
Published: March 2023

Abstract
We characterize Galactic dust filaments by correlating BICEP/Keck and Planck data with polarization templates based on neutral hydrogen (H i) observations. Dust polarization is important for both our understanding of astrophysical processes in the interstellar medium (ISM) and the search for primordial gravitational waves in the cosmic microwave background (CMB). In the diffuse ISM, H i is strongly correlated with the dust and partly organized into filaments that are aligned with the local magnetic field. We analyze the deep BICEP/Keck data at 95, 150, and 220 GHz, over the low-column-density region of sky where BICEP/Keck has set the best limits on primordial gravitational waves. We separate the H i emission into distinct velocity components and detect dust polarization correlated with the local Galactic H i but not with the H i associated with Magellanic Stream i. We present a robust, multifrequency detection of polarized dust emission correlated with the filamentary H i morphology template down to 95 GHz. For assessing its utility for foreground cleaning, we report that the Hi morphology template correlates in B modes at a ∼10%–65% level over the multipole range 20 < ℓ < 200 with the BICEP/Keck maps, which contain contributions from dust, CMB, and noise components. We measure the spectral index of the filamentary dust component spectral energy distribution to be β = 1.54 ± 0.13. We find no evidence for decorrelation in this region between the filaments and the rest of the dust field or from the inclusion of dust associated with the intermediate velocity H i. Finally, we explore the morphological parameter space in the H i-based filamentary model.
Weak-lensing Mass Bias in Merging Galaxy Clusters
Authors: Lee Wonki , Cha Sangjun , Jee M. James , Nagai Daisuke , King Lindsay , ZuHone John , Chadayammuri Urmila , Felix Sharon , Finner Kyle 
Published: March 2023

Abstract
Although weak lensing (WL) is a powerful method to estimate a galaxy cluster mass without any dynamical assumptions, a model bias can arise when the cluster density profile departs from the assumed model profile. In a merging system, the bias is expected to become most severe because the constituent halos undergo significant structural changes. In this study, we investigate WL mass bias in binary cluster mergers using a suite of idealized hydrodynamical simulations. Realistic WL shear catalogs are generated by matching the source galaxy properties, such as intrinsic shape dispersion, measurement noise, source densities, etc., to those from Subaru and Hubble Space Telescope observations. We find that, with the typical mass–concentration (M–c) relation and the Navarro–Frenk–White profile, the halo mass bias depends on the time since the first pericenter passage and increases with the mass of the companion cluster. The time evolution of the mass bias is similar to that of the concentration, indicating that, to first order, the mass bias is modulated by the concentration change. For a collision between two ∼1015
M
⊙ clusters, the maximum bias amounts to ∼60%. This suggests that previous WL studies may have significantly overestimated the mass of the clusters in some of the most massive mergers. Finally, we apply our results to three merger cases: A2034, MACS J1752.0 + 4440, and ZwCl 1856.8 + 6616, and report their mass biases at the observed epoch, as well as their pre-merger masses, utilizing their merger shock locations as tracers of the merger phases.
Classification of BATSE, Swift, and Fermi Gamma-Ray Bursts from Prompt Emission Alone
Authors: Steinhardt Charles L. , Mann William J. , Rusakov Vadim , Jespersen Christian K. 
Published: March 2023

Abstract
Although it is generally assumed that there are two dominant classes of gamma-ray bursts (GRBs) with different typical durations, it has been difficult to classify GRBs unambiguously as short or long from summary properties such as duration, spectral hardness, and spectral lag. Recent work used t-distributed stochastic neighborhood embedding (t-SNE), a machine-learning algorithm for dimensionality reduction, to classify all Swift GRBs as short or long. Here, the method is expanded, using two algorithms, t-SNE and UMAP, to produce embeddings that are used to provide a classification for 1911 BATSE bursts, 1321 Swift bursts, and 2294 Fermi bursts for which both spectra and metadata are available. Although the embeddings appear to produce a clear separation of each catalog into short and long bursts, a resampling-based approach is used to show that a small fraction of bursts cannot be robustly classified. Further, three of the 304 bursts observed by both Swift and Fermi have robust but conflicting classifications. A likely interpretation is that in addition to the two predominant classes of GRBs, there are additional, uncommon types of bursts which may require multiwavelength observations in order to separate them from more typical short and long GRBs.
A Systematic Magnetic Polarity Inversion Line Data Set from SDO/HMI Magnetograms
Authors: Ji Anli , Cai Xumin , Khasayeva Nigar , Georgoulis Manolis K. , Martens Petrus C. , Angryk Rafal A. , Aydin Berkay 
Published: March 2023

Abstract
Magnetic polarity inversion lines (PILs) detected in solar active regions have long been recognized as arguably the most essential feature for triggering instabilities such as flares and eruptive events (i.e., eruptive flares and coronal mass ejections). In recent years, efforts have been focused on using features engineered from PILs for solar eruption prediction. However, PIL rasters and metadata are often generated as by-products and are not accessible for public use, which limits their utilization in data-intensive space weather analytics applications. We introduce a large-scale publicly available PIL data set covering practically the entire solar cycle 24 for applying to various space weather forecasting and analytics tasks. The data set is created using both radial magnetic field (B_r) and line-of-sight (B_LoS) magnetograms from the Solar Dynamics Observatory’s Helioseismic and Magnetic Imager Active Region Patches (HARP) that involve 4090 HARP series ranging from 2010 May to 2019 March. This data set includes three PIL-related binary masks of rasters: the actual PILs as per the spatial analysis of the magnetograms, the region of polarity inversion, and the convex hull of PILs, along with time-series-structured metadata extracted from these masks. We also provide a preliminary exploratory analysis of selected features aiming to correlate time series of feature metadata and eruptive activity originating from active regions. We envision that this comprehensive PIL data set will complement existing data sets used for space weather forecasting and benefit research in related areas, specifically in better understanding the PIL structure, evolution, and role in eruptions.
Young Stellar Objects, Accretion Disks, and Their Variability with Rubin Observatory LSST
Authors: Bonito R. , Venuti L. , Ustamujic S. , Yoachim P. , Street R. A. , Prisinzano L. , Hartigan P. , Guarcello M. G. , Stassun K. G. , Giannini T. , Feigelson E. D. , Caratti o Garatti A. , Orlando S. , Clarkson W. I. , McGehee P. , Bellm E. C. , Gizis J. E. 
Published: March 2023

Abstract
Vera C. Rubin Observatory, through the Legacy Survey of Space and Time (LSST), will allow us to derive a panchromatic view of variability in young stellar objects (YSOs) across all relevant timescales. Indeed, both short-term variability (on timescales of hours to days) and long-term variability (months to years), predominantly driven by the dynamics of accretion processes in disk-hosting YSOs, can be explored by taking advantage of the multiband filters option available in Rubin LSST, in particular the u, g, r, i filters that enable us to discriminate between photospheric stellar properties and accretion signatures. The homogeneity and depth of sky coverage that will be achieved with LSST will provide us with a unique opportunity to characterize the time evolution of disk accretion as a function of age and varying environmental conditions (e.g., field crowdedness, massive neighbors, metallicity) by targeting different star-forming regions. In this contribution to the Rubin LSST Survey Strategy Optimization Focus Issue, we discuss how implementing a dense observing cadence to explore short-term variability in YSOs represents a key complementary effort to the Wide–Fast–Deep observing mode that will be used to survey the sky over the full duration of the main survey (≈10 yr). The combination of these two modes will be vital to investigate the connection between the inner-disk dynamics and longer-term eruptive variability behaviors, such as those observed on EX Lupi–type objects.
La transmodalisation, un levier pour une inclusion efficiente des élèves allophones ?
Authors: Prévost Julie 
Published: March 2023

L’article interroge la transmodalisation et ses effets pour les élèves allophones inclus ou à inclure en cours de français disciplinaire, à partir d’une fonction expériencielle double : en tant que professeure de lettres modernes, d’une part, en tant que professeure de français langue seconde et scolaire (FLS/FLSco) dans une unité pédagogique pour élèves allophones nouvèlement arrivés (UPE2A) de collège, d’autre part. L’étude analyse plusieurs des contraintes effectives qui agissent sur les démarches didactiques intégrant la transmodalisation. Il en ressort que cette transmodalisation constitue l’un des leviers pour une accessibilité au sens et, conséquemment, une inclusion efficiente dans le cadre d’enseignements ordinaires.
Entre transmodalité et multimodalité : quelle(s) lecture(s) de Madame Bovary ?
Authors: Cuin Marie-Hélène 
Published: March 2023

L’article présente un dispositif d’enseignement de lecture littéraire mis en œuvre pour une classe de Seconde autour de l’étude en œuvre intégrale de Madame Bovary de Flaubert. Il interroge la nature et les usages des objets sémiotiques secondaires transmodaux et multimodaux en réception et en production, mis en dialogue avec les écrits textuels. La séquence intègre des objets transmodaux en réception afin de faciliter l’entrée dans l’œuvre princeps , sa contextualisation et son actualisation ; elle inclut également un écrit médiatique multimodal considéré comme un texte du lecteur transmodal. Si l’expérimentation menée au sein de deux classes au profil différent a permis de mettre en évidence une implication accrue des élèves pour l’œuvre patrimoniale et sa lecture, en revanche la multiplication des supports et des modalités de lecture semble accentuer les difficultés des élèves les plus fragiles et aggraver les inégalités socioculturelles.
Lectures et contre-lectures du Journal d’un chat assassin en CE2-CM1 : un éclairage interprétatif par la BD ?
Authors: Castagnet-Caignec Sonia 
Published: March 2023

La contribution s’attache à analyser comment une œuvre et son adaptation transmodale peuvent contribuer à développer des compétences de compréhension-interprétation chez des élèves de fin de cycle 2, début de cycle 3 du cursus primaire. L’étude s’appuie sur une œuvre recommandée par le ministère de l’Éducation nationale, Journal d’un chat assassin , court roman illustré d’Anne Fine, adapté en BD par Véronique Deiss. Trois classes ont étudié les deux ouvrages dans une séquence d’enseignement-apprentissage en lecture littéraire, suivant deux protocoles didactiques différents : succession des ouvrages et alternance des ouvrages avec dominante roman ou BD. Les retours sur la séance finale ainsi que sur les obstacles rencontrés par les élèves, notamment lors de la lecture-compréhension d’images transposant un récit à la première personne, permettent de dégager les bénéfices et les limites d’une lecture comparée d’une œuvre et de son adaptation pour un jeune public scolaire.