bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Immunopathy of Alzheimer’s Disease: Innate or Adaptive?
Authors: Weaver Donald F. 
Published: May 2023

Abstract:
Beyond the time-honoured targeting of protein misfolding and aggregation, Alzheimer’s disease needs new, innovative therapeutic directions. When exploring alternative druggable mechanisms, multifaceted in vitro and in vivo data demonstrate that immune system dysfunction is a pivotal driver of Alzheimer’s disease progression. In pursuing neuroimmunological targets, a major but often under-discussed consideration regards the issue of whether innate or adaptive immunity (or both) within the neuroimmune network should be the centre of focus when devising immunotherapeutic approaches to Alzheimer’s. This perspective article briefly reviews current data, concluding that while both innate and adaptive immunity contributes to the immunopathology of Alzheimer’s, the pro-inflammatory microglia and cytokines of innate immunity will provide higher yield targets with a greater likelihood of efficacy. Although it seems paradoxical to focus on a rapid, short-lived aspect of immunity when seeking approaches to a quintessentially chronic brain disease, accumulating evidence affords ample data to support the target-rich cascade of innate immunity for the development of much-needed new diagnostics and therapeutics.
Treatment of Peri-implant Diseases using Lasers: A Systematic Review
Authors: AlMarzooqi Amna Mohamed Abdulla , Ramachandra Srinivas Sulugodu , Kukreja Bhavna Jha , Reddy Sesha , Souza Jovita Lawrence D. , Abdelmagyd Hossam Abdelatty Eid 
Published: May 2023

Background:
Adjuncts to mechanical debridement, including administration of systemically and locally delivered antimicrobials, are constantly evaluated to achieve additional benefits while treating peri-implantitis. However, the potential for the development of antimicrobial resistance limits their use. Evaluation of the use of lasers for the treatment of peri-implantitis has provided varying results.

Objective:
This study aimed to summarize the existing literature on the additional benefits of lasers as adjuncts to mechanical debridement while treating peri-implant diseases.

Methods:
Randomised clinical trials published in English till Sept 2022 in PubMed, Medline, and clinical trial registries using the MeSH terms “peri-implant diseases”, “peri-implant mucositis”, “peri-implantitis”, and “lasers”, were included in the study. Case reports, case series, longitudinal studies, and retrospective analysis were excluded.

Results:
A total of fifteen (n=15) randomised clinical trials pertaining to peri-implantitis and three (n=3) trials pertaining to peri-implant mucositis were assessed. The trials assessed the use of diode, Nd: YAG, Er:YAG, CO2 lasers, and photodynamic therapy as adjuncts in the treatment of peri-implant diseases.

Conclusion:
The existing evidence regarding the use of laser for peri-implant mucositis is inconclusive, whereas for peri-implantitis, the majority of the studies support the use of lasers. Future trials should utilize the 2018 classification of peri-implantitis, so that a comparison of trials based on the studied parameters would be more accurate.
A Network Medical Framework based on Inflammatory Genes to Identify Drug
Candidates for Abdominal Aortic Aneurysms
Authors: Wang Bing , Niu Xiaoyang 
Published: May 2023

Background:
Clinically, abdominal aortic aneurysms (AAA) can be treated with surgical intervention, but there is currently no effective drug for the disease.

Methods:
This study analyzed the biomedical data of single-cell RNA sequencing (scRNA-seq), RNA-seq and the network medical data of drug-target interaction as well as protein-protein interaction to identify key targets and potential drug compounds of AAA.

Results:
Firstly, we identified 10 types of cells from AAA and nonaneurysmal control samples and screened monocyte, mast cell, smooth muscle cell and
327 genes showing significant differences between non-dilated PVATs and dilated PVATs. To further explore the association of three types of
cells in AAA, we screened the common DEGs associated with the three types of cells and then identified 10 potential therapeutic targets for AAA.
SLC2A3 and IER3 were the key targets that were the most closely related to immune score and significantly related to inflammatory pathways. We
then designed a network-based proximity measure to identify potential drugs targeting SLC2A3. Finally, with computer simulation, we found that
the compound with the highest affinity to SLC2A3 protein was DB08213, which was embedded into the SLC2A3 protein cavity and formed close
contact with various amino acid residues, and was stable during the 100-ns MD simulation.

Conclusions:
This study provided a computational framework for drug design and development. It revealed key targets and potential therapeutic drug compounds for AAA, which might contribute to the drug development for AAA.
Tuning green-to-red ratio of Ho3+ Activated YPO4 dual-mode luminescence through Yb3+ sensitized nano phosphors
Authors: Putta Venkata Nagendra Kumar , Bandi Sirisha , Koneru Girija Venkateswara , Kanuparthy Phani Raja 
Published: May 2023

INTRODUCTION:
Yb3+/Ho3+co-doped YPO4 nano phosphors were synthesized by polyol route, which has both up-conversion (UC) and down-conversion (DC) characteristics and excellent luminescent properties. DC peaks were seen at ~460, ~550, and ~650 nm.

METHOD:
Switching at ~750 with 300 nm excitation, a very faint P-O charge-transfer (CT) band of the Ho3+ ion and a minute non-radiative resonant energy transfer were observed. We found that YPO4: Yb3+/Ho3+ is an up-converting (UC ) nano phosphor capable of large-scale generation and enhancement of luminescence with green and red emissions.RESULT: Under strong laser irradiation at 980 nm, the up-conversion emission spectrum shows obvious peaks expected for Ho3+ ions at ~550 and ~650 nm. This process produces high-quality nanocrystalline materials with sizes in the range of tens of nm. Considering the results obtained under excitation at 300nm, YPO4:Yb3+/Ho3+ yielded high quantum yield values

CONCLUSION:
This finding can be used to manufacture high-efficiency phosphors and demonstrates that the nano-phosphor materials covered by this method have a wide range of applications.
Temporary anchorage devices in orthodontics: a bibliometric analysis of the 50 most-cited articles from 2012 to 2022
Authors: Ferrillo Martina , Nucci Ludovica , Gallo Vittorio , Bruni Alessandro , Montrella Roberta , Fortunato Leonzio , Giudice Amerigo , Perillo Letizia 
Published: May 2023

ABSTRACT

Objectives
To identify and analyze the 50 most cited articles on temporary anchorage devices (TADs) and investigate the achievement and development of scientific research about the topic through a bibliometric analysis.

Materials and Methods
On August 22, 2022, a computerized database search was performed to detect papers published in the scientific literature about TADs from 2012 to 2022. Metrics data were identified using the Incites Journal Citation Reports (Clarivate Analytics) data set. The Scopus database was used to obtain information on the authors’ affiliations, country of origin, and h-index. Key words were automatically harvested from the selected articles to implement the visualized analysis.

Results
From a total of 1858 papers screened by searching the database, a list of the top 50 most cited articles was created. The total number of citations collected by the 50 most cited articles in TADs was 2380. Among the 50 most cited articles on TADs, 38 were original research papers (76.0%) and 12 were reviews (24.0%). As shown by the key word–network analysis, Orthodontic anchorage procedure was identified as the larger node.

Conclusions
Findings of this bibliometric study showed an increasing number of citations for papers on TADs, accompanied by a simultaneous rise in scientific interest in this topic in the past decade. The present work identifies the most influential articles, emphasizing the journals, the authors, and the topics addressed.
Treatment planning protocols with the Invisalign appliance: an exploratory survey
Authors: Meade Maurice J. , Weir Tony 
Published: May 2023

ABSTRACT

Objectives
To investigate the changes made by orthodontists to the initial digital treatment plan (DTP) regarding the Invisalign appliance provided by Align Technology until acceptance of the plan by the orthodontist.

Materials and Methods
The DTPs of subjects who underwent treatment with the Invisalign appliance and satisfied inclusion criteria were assessed to determine the number of DTPs and changes regarding prescription of aligners, composite resin (CR) attachments, and interproximal reduction (IPR) between the initial DTP and the accepted plan. Statistical analyses were calculated via GraphPad Prism 9.0 (GraphPad Software Inc., La Jolla, Calif).

Results
Most of the 431 subjects who satisfied inclusion/exclusion criteria were female (72.85%). More DTPs were required for subjects who had orthodontic extractions (median [interquartile range; IQR]: 4 [3, 5]) compared with those who did not (median [IQR]: 3 [2, 4], P &lt; .0001). The median (IQR) overall number of aligners prescribed in the accepted DTP (30 [20, 39]) was greater than the initial DTP (30 [22,41], P &lt; .001). The number of teeth used for CR attachments increased from the initial to the accepted DTP (P &lt; .001). More CR attachments were observed in extraction treatment DTPs with a prescribed 2-week aligner change protocol compared with nonextraction treatment (P &lt; .0001). The number of contact points with prescribed IPR increased between initial and accepted DTPs (P &lt; .0001).

Conclusions
Significant changes regarding DTP protocols were observed between the initial and accepted DTPs and between nonextraction and extraction-based CAT.
Organization of the control and supervisory system in the field of regulation of land and property relations at the municipal level
Authors: Tikhonova K. V. , Burdova D. V. , Tikhonov D. A. , Yakunina T. G. 
Published: May 2023

The economic conditions of land resources management, dynamics and trends of increasing rates of intensification of their use are considered. The necessity of introducing new approaches to optimizing the mechanisms of regulation of land and property relations through the modernization of the regulatory framework regulating this field of activity is substantiated.
Despite a significant number of regulatory legal acts regulating the control functions for the use of land resources at the municipal level, the mechanism of its implementation is not perfect, as evidenced by the statistics of violations of land legislation by subjects of land and property relations. The analysis of statistical data of the main offenses in the field of use of land resources is given.
Preparation and characterization of non-isocyanate polyurethane resins derived from tannin of Acacia mangium bark for the modification of ramie fibers
Authors: Aristri Manggar Arum , Lubis Muhammad Adly Rahandi , Sari Rita Kartika , Kristak Lubos , Iswanto Apri Heri , Mardawati Efri , Hua Lee Seng 
Published: May 2023

Abstract
The purpose of this research was to create bio-based non-isocyanate polyurethane (Bio-NIPU) resins derived from the tannin of Acacia mangium Willd. bark for the impregnation of ramie fibres (Boehmeria nivea L.) and to investigate the properties of impregnated fibres. Tannin was extracted from the bark of A. mangium using hot water. Tannin-bio-NIPU resin was created using dimethyl carbonate and hexamine. Based on the findings, it is possible to conclude that tannin extract from the bark of Acacia mangium can be used effectively as a renewable alternative to toxic polyols in the development of tannin-Bio-NIPU resins. FTIR spectroscopy was used to confirm the urethane bond formed on the tannin-Bio-NIPU resins. Thermal and mechanical analysis were used to investigate the properties of tannin-Bio-NIPU resins and ramie fibres before and after impregnation. This study shows that the impregnation time of ramie fiber using tannin-Bio-NIPU resins is 30 minutes. The reaction between tannin-Bio-NIPU resins with ramie fiber forms the C=O urethane group as confirmed by FTIR Spectroscopy. The characterization results show that tannin-Bio-NIPU resins has ability to modify ramie fiber via impregnation in order to increase its mechanical properties, thus enhancing its potential for wider industrial application as a functional material.
Effect of laser cutting of oak wood on the drying process
Authors: Klement Ivan , Igaz Rastislav , Gergeľ Tomáš , Vilkovská Tatiana , Drugdová Jennifer 
Published: May 2023

Abstract
The subject of this paper is the analysis of the influence of laser cutting of oak wood on its drying process. The subject of the research was the comparison of the drying process and the quality of the dried wood in samples cut by classical technology (sawing) and samples cut with the use of laser. The research was carried out on two sets of samples which were subjected to an identical drying process. Continuous moisture loss and final moisture attained, moisture gradients before and after drying, and internal tensions before and after drying were monitored by means of the fork test and the cut-test. The final moisture content at the end of drying was 8.09% for the saw-cut samples and 8.22% for the laser-cut samples, a difference of only 0.13%. The analysis of the individual characteristics observed showed that the influence of the cutting technology did not have a significant effect on the drying process or the quality of the dried oak sawn timber.
Avaliação do nível de coordenação motora em escolares do 4° e 5° anos do ensino fundamental i da rede municipal de ensino
Authors: Couto Fernanda Maria do , Leal José Carlos , Cordeiro Geraldo Henrique Matias , Silva Jorge Edson Santos , Couto Daniela Paula do , Vieira Túlio César , Melo Igor Tales Oliveira 
Published: May 2023

Introdução: O desenvolvimento da coordenação motora é essencial na vida da criança especialmente para o aprimoramento do seu campo motor e se constitui como um alicerce para o movimento coordenado e eficiente. O desenvolvimento psicomotor de uma criança é pré-requisito para a realização de tarefas mais complexas na vida escolar, social e esportiva e um trabalho ineficiente da escola acarretará sérios problemas de aprendizado mais tarde. Objetivo: Avaliar o nível de coordenação motora de escolares do 4° e 5° anos do ensino fundamental I da rede municipal de ensino. Metodologia: A pesquisa de caráter quantitativo, observacional e transversal foi realizada em uma escola da rede municipal de ensino com escolares na faixa etária entre nove e 10 anos. A amostra foi composta por 107 escolares. Para avaliar o nível de coordenação motora foi utilizado o teste KTK, composto por quatro provas: Trave de Equilíbrio, Saltos Monopedais, Saltos Laterais e Transferências sobre Plataformas. Resultados: As crianças apresentaram maior rendimento na Trave de Equilíbrio, com média (95,2), e menor rendimento em Saltos Laterais (78,5). O quociente motor geral dos escolares foi de 104,9. Conclusão: O trabalho da Educação Física referente ao desenvolvimento da coordenação motora na escola onde foi realizada a pesquisa se mostra eficiente já que a maior parte dos escolares teve sua coordenação motora classificada como normal.

Palavras-chave: Coordenação motora; Infância; Psicomotricidade.
Investigation of corrosion behaviour of defective pipelines within weld area
Authors: Гомес И.М. , да Cилва Т.Ф. 
Published: May 2023

Проблема обеспечения безопасной эксплуатации трубопроводов во многом является проблемой повышения их коррозионной стойкости и коррозионно-механической прочности. Несмотря на современные достижения в этой области, некоторые вопросы остаются открытыми. С позиций общей теории коррозионной усталости металлов сварные соединения являются одними из наиболее сложных объектов. При их эксплуатации возникают проблемы, связанные с неоднородностью свойств материала, сложностью структуры, наличием конструктивных и технологических концентраторов напряжений, остаточных напряжений и т. д. Целью работы является анализ коррозионного поведения стальной трубы API X65 с трещиной в зоне продольного сварного шва в нижней образующей. В рамках исследования проведены анализ химического состава и металлографический анализ в различных участках трубы, макроанализ сварного шва, макроанализ дефекта с использованием стереосъемки, анализ методом растровой электронной микроскопии, измерение микротвердости по Виккерсу, анализ химического и фазового состава продуктов коррозии, оценка строения дефектов с использованием внутритрубной диагностики и автоматизированного ультразвукового контроля. Предложены рекомендации по снижению рисков разрушения трубопровода с коррозионными повреждениями.
The problem of ensuring safe operation of pipelines is largely a problem of increasing their corrosion resistance and corrosion-mechanical strength. Despite modern achievements in this field, some issues remain not solved. From the standpoint of the general theory of corrosion fatigue of metals, welded joints are among the most complex objects. During operation, problems arise related to heterogeneity of the weld material properties, complexity of structure, presence of structural and technological stress concentrators, residual stresses, etc. The study purpose is to analyze corrosion behavior of API X65 steel pipe with a crack in the zone of longitudinal weld in lower generatix. As part of the study, chemical composition analysis and metallographic analysis in various sections of the pipe, macro analysis of the weld, macro analysis of the defect using stereo photography; analysis by scanning electron microscopy, Vickers microhardness measurement, analysis of the chemical and phase composition of corrosion products, evaluation of structure of defects using in-pipe diagnostics and automated ultrasound control were carried out. Recommendations for reducing risks of pipeline destruction with corrosion damage are proposed.
PENINGKATAN KESADARAN AKAN KESELAMATAN DAN KESEHATAN KERJA MELALUI REVITALISASI PENGGUNAAN ALAT PELINDUNG DIRI UNTUK KARYAWAN KERAJINAN KULIT KERANG MUTIARA “CONCHA” HANDYCRAFT
Authors: Joniarta I Wayan , Wijana Made , Wiratama I Kade , Nuarsa I Made , Okariawan I Dewa 
Published: May 2023

Concha Handycraft sebagai usaha rintisan anak muda, memproduksi produk kreatif , Usaha ini khusus mengolah limbah-limbah produksi kerajinan kulit kerang.. Bagian proses yang paling banyak menghasilkan debu adalah proses mengupas dan memotongkulit kerang..Permasalahan yang ada yaitu, ketersediaaan alat pelindung diri, kesadaran dalam penggunannya.Metode yang digunakan adalah penyuluhan penggunaan alat pelindung diri, peragaaan penggunaan langsung bekerja dan memberi bantuan untuk pengadaan alat pelindung diri.Hasil pengabdian dikaji secara kuantitatif dengan menggunakan kuisioner SkalaLikert.Setelah kegiatan pengabdian ini terlaksana maka, sudah adapenyediaan jumlah Alat Pelindung Diri (APD) secara memadai, bahwa ada peningkatan kecukupan APD untuk semua karyawan yang bekerja di Concha Handycraft dengan rata-rata sebesar 46.40%. Peningkatan kecukupan APD yang tertinggi adalah pada masker yaitu 60 %, dan yang terendah adalah peningkatan kecukupan pada penutup kepala (topi) sebesar 32.00 %. Kesadaran menggunakan APD tersebut juga meningkat, untuk semua karyawan yang bekerja di Concha Handycraft dengan rata-rata sebesar 48.80%. Tertinggi dalam menggunakan Sarung tangan yaitu 68 %, dan yang terendah adalah peningkatan kesadaran menggunakan clemek (Apron), sebesar 32.00 %. Dari segi kenyamanan menggunakan APD bahwa ada peningkatan untuk semua karyawan yang bekerja di Concha Handycraft dengan rata-rata sebesar 49,60%. Untuk yang tertinggi pada penggunaan sarung tangan yaitu 60 %, dan yang terkecil adalah penggunaan clemek (Apron), sebesar 40.00 %. Perubahan-perubahan yang terjadi pada karyawan ke arah yang lebih baik akan mampu mendorong adanya peningkatan produktiftas usaha, sehingga bisa berkelanjutan.
RUMAH BIBIT HORTUKULTURA SEBAGAI SOLUSI KETAHANAN PANGAN KELUARGA DI DESA SAMA GUNA KECAMATAN TANJUNG KABUPATEN LOMBOK UTARA NUSA TENGGARA BARAT
Authors: Aryana I Gusti Putu Muliarta , Alfitmatun Alfitmatun , Putri Aulia Shara , Khilafatulqudduus Ghalby , Nensi Baiq Arya , Ramdani Wahyu , Astarina Raditia , Kumairah Titi , Agustina Agustina , Puspitasari Apin , Wikanto Aditya Kusuma 
Published: May 2023

Pembangunan rumah bibit menjadi solusi guna memenuhi kebutuhan pangan keluarga. Rumah bibit merupakaan cara penerapan pertanian berkelanjutan, rumah bibit dibuat agar penyemaian benih dapat berlangsung dengan kondisi iklim terkendali. Hal ini diperlukan untuk pertumbuhan tanaman yaitu dengan memperhatikan suhu, perhitungan transmisi cahaya dan mengatur kelembaban udara secara merata sesuai dengan kebutuhan tanaman. Permasalahan yang dialami oleh kebanyakan masyarakat adalah kurangnya suplay bibit siap tanam. Oleh karena itu tujuan dari kegiatan ini adalah terbentuknya rumah bibit dan bibit tanaman hortikultura yaitu cabe, sawi dan kangkung yang berkualitas. Metode pelaksanaan kegiatan dilakukan dengan 3 tahapan, yakni survei lokasi, sosialiasi dan membangun rumah bibit serta penamanan dan pemeliharaan bibit. Hasil kegiatan menunjukkan bahwa telah terbentuk rumah bibit hortikultura dan hasil pembibitan cabe, sawi dan kanggkung yang dapat memenuhi kebutuhan suplay masyarakat akan bibit hortikultura dengan mutu yang lebih baik.
Validitas Instrumen Pengembangan Video Pembelajaran Matematika Berbasis Software Wondershare Filmora Untuk Meningkatkan Minat Belajar Peserta Didik Materi Penyajian Didik Kelas VII SMP/MTs
Authors: Risali Hafizah , Zulfah Zulfah , Rizki Lussy Midani 
Published: May 2023

This research is based on the problems that exist in schools namely the lack of student interest in learning mathematics and this requires an innovation of learning media used in schools during the teaching and learning process. This study aims to produce quality instrument validation that will be used in assessing mathematics learning videos based on the wondershare filmora software. This development research uses the Plomp model. The Plomp model consists of 3 stages, preliminary research, prototyping stage and assessment stage. The subjects of this research are 3 expert validators who are competent in their respective fields. This study uses instrument validity, practicality and effectiveness. The research data were collected using observation sheets, interviews and questionnaires. The data analysis techniques used are preliminary data analysis, data validity analysis, data practicality analysis, and data effectiveness analysis. the results of the assessment sheet of interview questions, observations and questionnaires using instrument validation state that these three things are in the very valid category, so that interviews, observations and questionnaires have been used to obtain data and information on the study.
Interaksi Kelas Online pada Kurikulum Merdeka Belajar di Lingkungan Perguruan Tinggi
Authors: Pamungkas Ageng Satria , Ikhlas Al , Moeis Dikwan , Sitopu Joni Wilson , Purhanudin MS Viktor 
Published: May 2023

Online learning that has been carried out so far cannot be separated from problems such as unstable internet networks, which result in less than optimal teaching and learning processes. In addition, there is still very limited research that examines online interactions so it needs to be carried out considering that the learning system will not necessarily be carried out normally with a face-to-face process in the classroom. The purpose of this research was to determine the interaction that occurred in the online class of STKIP Muhammadiyan Sungai Full students. The method used by researchers in this study is the mixed method (Mix Method). The sample used in this study was mathematics education students. Sampling is carried out by purposive sampling. The analysis was carried out with stages: making transcripts of teaching and learning processes, coding, classifying online class interaction patterns, model interaction characteristics FIAC (Flander Interaction Analysis Code) and model BIAS (Brown Interaction Analysis System).