bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and risk factors for cholelithiasis after bariatric surgery: a systematic review and meta-analysis
Authors: Dai Yu , Luo Bujiangcun , Li Weizheng 
Published: January 2023

Abstract
Background
Obesity has been identified as an independent risk factor for cholelithiasis. As a treatment for obesity, bariatric surgery may increase the incidence of cholelithiasis. The risk factors for cholelithiasis after bariatric surgery remain uncertain. The purpose of this study was to explore the risk factors for postoperative cholelithiasis after weight-loss surgery and propose suggestions for clinical decision making.

Methods
Four databases, PubMed, EMBASE, Web of Science and Cochrane, were systematically searched for all reports about cholelithiasis after bariatric surgery, and literature screening was performed following prespecified inclusion criteria. The included studies were all evaluated for quality according to the NOS scale. Data extraction was followed by analysis using Reviewer Manager 5.4 and StataSE 15.

Results
A total of 19 articles were included in this meta-analysis, and all studies were of high quality. A total of 20,553 patients were included in this study. Sex [OR = 0.62, 95% CI (0.55, 0.71), P < 0.00001] and race [OR = 1.62, 95% CI (1.19, 2.19), P = 0.002] were risk factors for cholelithiasis after bariatric surgery. Surgical procedure, preoperative BMI, weight-loss ratio, smoking, hypertension, diabetes mellitus, and dyslipidemia were neither protective nor risk factors for cholelithiasis after bariatric surgery.

Conclusion
Caucasian race and female sex are risk factors for developing cholelithiasis after bariatric surgery; surgical procedure, BMI, weight loss ratio, hypertension, diabetes mellitus, dyslipidemia, and smoking are not risk factors for cholelithiasis after bariatric surgery.
Exploring high-density corticomuscular networks after stroke to enable a hybrid Brain-Computer Interface for hand motor rehabilitation
Authors: Pichiorri Floriana , Toppi Jlenia , de Seta Valeria , Colamarino Emma , Masciullo Marcella , Tamburella Federica , Lorusso Matteo , Cincotti Febo , Mattia Donatella 
Published: January 2023

AbstractBackgroundBrain-Computer Interfaces (BCI) promote upper limb recovery in stroke patients reinforcing motor related brain activity (from electroencephalogaphy, EEG). Hybrid BCIs which include peripheral signals (electromyography, EMG) as control features could be employed to monitor post-stroke motor abnormalities. To ground the use of corticomuscular coherence (CMC) as a hybrid feature for a rehabilitative BCI, we analyzed high-density CMC networks (derived from multiple EEG and EMG channels) and their relation with upper limb motor deficit by comparing data from stroke patients with healthy participants during simple hand tasks.MethodsEEG (61 sensors) and EMG (8 muscles per arm) were simultaneously recorded from 12 stroke (EXP) and 12 healthy participants (CTRL) during simple hand movements performed with right/left (CTRL) and unaffected/affected hand (EXP, UH/AH). CMC networks were estimated for each movement and their properties were analyzed by means of indices derived ad-hoc from graph theory and compared among groups.ResultsBetween-group analysis showed that CMC weight of the whole brain network was significantly reduced in patients during AH movements. The network density was increased especially for those connections entailing bilateral non-target muscles. Such reduced muscle-specificity observed in patients was confirmed by muscle degree index (connections per muscle) which indicated a connections’ distribution among non-target and contralateral muscles and revealed a higher involvement of proximal muscles in patients. CMC network properties correlated with upper-limb motor impairment as assessed by Fugl-Meyer Assessment and Manual Muscle Test in patients.ConclusionsHigh-density CMC networks can capture motor abnormalities in stroke patients during simple hand movements. Correlations with upper limb motor impairment support their use in a BCI-based rehabilitative approach.
Forty-five-months follow-up of a minimally invasive, interdisciplinary treated hemangioma of the mandible with a high risk of severe bleeding – a case report
Authors: Ommerborn Michelle Alicia , John Gordon , Becker Jürgen , Preetz Julia , Gabris Sondos 
Published: January 2023

Abstract
Background
Hemangiomas are benign tumours, mostly seen in the soft tissues. The intraosseous appearance is rare, in particular in the jaws they represent a very seldom malformation.

Aim
To present a combined endodontic and surgical management report of a clinical case with a rare intraosseous hemangioma diagnosis in the mandible.

Case presentation
This well-documented case report describes the interdisciplinary treatment approach of an intraosseous hemangioma in the left mandible of a 70-year-old male patient. This incidental finding was detected through a routine dental examination. The panoramic radiograph revealed an asymptomatic, apical translucency approximately 15 mm diameter with contact to the mesial root of the tooth 36. The clinical examinations showed no abnormalities. The multifaceted specialized treatments started with the endodontic treatment of the tooth prior to the surgical removal of the lesion and were followed by the histological assessment. As derived from the histologically verified diagnosis, this rare case included the risk of severe bleeding complications during therapy.
Bacteria spatial tracking in Urban Park soils with MALDI-TOF Mass Spectrometry and Specific PCR
Authors: Arnal Diego , Moya Celeste , Filippelli Luigi , Segura-Garcia Jaume , Maicas Sergi 
Published: January 2023

AbstractUrban parks constitute one of the main leisure areas, especially for the most vulnerable people in our society, children, and the elderly. Contact with soils can pose a health risk. Microbiological testing is a key aspect in determining whether they are suitable for public use. The aim of this work is to map the spatial distribution of potential dangerous Enterobacteria but also bioremediation useful (lipase producers) isolates from soils in an urban park in the area of Valencia (Spain). To this end, our team has collected 25 samples of soil and isolated 500 microorganisms, using a mobile application to collect information of the soil samples (i.e. soil features, temperature, humidity, etc.) with geolocation. A combined protocol including matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) and 16S rDNA sequencing PCR has been established to characterize the isolates. The results have been processed using spatial statistical techniques (using Kriging method), taking into account the number of isolated strains, also proving the reactivity against standard pathogenic bacterial strains (Escherichia coli, Bacillus cereus, Salmonella, Pseudomonas and Staphylococcus aureus), and have increased the number of samples (to 896 samples) by interpolating spatially each parameter with this statistical method. The combined use of methods from biology and computer science allows the quality of the soil in urban parks to be predicted in an agile way, which can generate confidence in its use by citizens.
Can circulating cell free DNA be a promising marker in ovarian cancer? – a genome-scale profiling study in a single institution
Authors: Zhou Huimei , Zhang Xueying , Liu Qian , Yang Jiaxin , Bai Jian , Yin Min , Cao Dongyan , Zhang Qingzheng , Zheng Lu 
Published: January 2023

Abstract
Background
Cell-free DNA (cfDNA) is emerging as a potential biomarker for the detection of ovarian cancer (OC). Recently, we reported a method based upon cfDNA whole-genome sequencing data including the nucleosome distribution (nucleosome footprinting NF), terminal signature sequence (motif), DNA fragmentation (fragment), and copy number variation (CNV).In the present study, we explored whether multiomics early screening technology in cfDNA can be applied for early screening of ovarian cancer.

Methods
Fifty-nine patients with OC and 100 healthy controls were included in this prospective study. Cell-free DNA was extracted from plasma and analyzed by low-pass whole-genome sequencing. Genomic features were obtained for all samples of the cohort, including copy number variation (CNV), 5’-end motifs, fragmentation profiles, and nucleosome footprinting (NF). An integrated scoring system termed the OC score was developed based on the performance of these four features.

Results
All four features showed diagnostic potential for OC. Based on the unique genome features of cfDNA, the OC score has high accuracy in distinguishing OC patients from healthy controls (AUC 97.7%; sensitivity 94.7%; specificity 98.0%) as a new comprehensive diagnostic method for OC. The OC score showed a gradual trend from healthy controls to OC patients with different stages, especially for early OC monitoring of concern, which achieved a satisfactory sensitivity (85.7%) at a high specificity.

Conclusions
This is the first study evaluating the potential of cell-free DNA for the diagnosis of primary OC using multidimensional early screening technology. We present a promising method to increase the accuracy of prediction in patients with OC.
Successful treatment with Omalizumab of a child affected by Systemic Mastocytosis: clinical and biological implications
Authors: Bossi Grazia , Brazzelli Valeria , De Amici Mara , Pietra Daniela , Raviola Chiara , Naso Matteo , Regalbuto Corrado , Boselli Federica , Fortina Valeria , Marseglia Gian Luigi 
Published: January 2023

Abstract
Background
Pediatric Mastocytosis is a rare and heterogeneous disease, characterized by accumulation of mast cells in the skin (Cutaneous Mastocytosis) and/or, less frequently, in other organs, mainly liver, spleen, bone marrow, lymph nodes and gastrointestinal tract (Systemic Mastocytosis). Patients affected by Systemic Mastocytosis show symptoms caused by a massive release of mast cell mediators: itching, flushing, abdominal pain, generalized weakness, fatigue and neuropsychiatric disorders. Moreover, children with Systemic Mastocytosis are at greater risk of anaphylactic/anaphylactoid reactions, often poorly controlled by the conventional therapy with antihistamines, mast cells stabilizers and steroids. As a result, children affected by Systemic Mastocytosis have a poor quality of life and suffer the consequence of prolonged steroidal treatment.

Case presentation
A child with Systemic Mastocytosis and severe symptoms, refractory to symptomatic and steroidal therapy, has been successfully treated with Omalizumab, an anti-IgE monoclonal antibody usually employed in allergic patients with severe asthma and orticaria. The onset of clinical benefit of Omalizumab therapy was extraordinarily rapid, but proved to be strictly dependent on drug administration. The child has become completely and steadily asymptomatic. No other anaphylactic episodes have been reported. Steroid treatment could be definitively withdrawn after the second dose of Omalizumab, and all the other medications were later reduced. Twenty months after beginning, Omalizumab therapy is still ongoing with good symptomatology control; no side effects have been observed so far.

Conclusions
In our experience, Omalizumab is an effective treatment for children affected by Systemic Mastocytosis not responding to conventional medical treatments. The main strengths of this therapy are its rapid and extraordinary efficacy to control the severe mast cells mediator-related symptoms, the lack of side effects and its steroid-sparing effect. However, more extensive and controlled studies in pediatric patients affected by Systemic Mastocytosis are needed to substantiate these promising findings.
Knowledge mobilization activities to support decision-making by youth, parents, and adults using a systematic and living map of evidence and recommendations on COVID-19: protocol for three randomized controlled trials and qualitative user-experience studies
Authors: Charide Rana , Stallwood Lisa , Munan Matthew , Sayfi Shahab , Hartling Lisa , Butcher Nancy J. , Offringa Martin , Elliott Sarah , Richards Dawn P. , Mathew Joseph L. , Akl Elie A. , Kredo Tamara , Mbuagbaw Lawrence , Motillal Ashley , Baba Ami , Prebeg Matthew , Relihan Jacqueline , Scott Shannon D. , Suvada Jozef , Falavigna Maicon , Klugar Miloslav , Lotfi Tamara , Stevens Adrienne , Pottie Kevin , Schünemann Holger J. 
Published: January 2023

Abstract
Introduction
The COVID-19 pandemic underlined that guidelines and recommendations must be made more accessible and more understandable to the general public to improve health outcomes. The objective of this study is to evaluate, quantify, and compare the public’s understanding, usability, satisfaction, intention to implement, and preference for different ways of presenting COVID-19 health recommendations derived from the COVID-19 Living Map of Recommendations and Gateway to Contextualization (RecMap).

Methods and analysis
This is a protocol for a multi-method study. Through an online survey, we will conduct pragmatic allocation-concealed, blinded superiority randomized controlled trials (RCTs) in three populations to test alternative formats of presenting health recommendations: adults, parents, and youth, with at least 240 participants in each population. Prior to initiating the RCT, our interventions will have been refined with relevant stakeholder input. The intervention arm will receive a plain language recommendation (PLR) format while the control arm will receive the corresponding original recommendation format as originally published by the guideline organizations (standard language version). Our primary outcome is understanding, and our secondary outcomes are accessibility and usability, satisfaction, intended behavior, and preference for the recommendation formats. Each population’s results will be analyzed separately. However, we are planning a meta-analysis of the results across populations. At the end of each survey, participants will be invited to participate in an optional one-on-one, virtual semi-structured interview to explore their user experience. All interviews will be transcribed and analyzed using the principles of thematic analysis and a hybrid inductive and deductive approach.

Ethics and dissemination
Through Clinical Trials Ontario, the Hamilton Integrated Research Ethics Board has reviewed and approved this protocol (Project ID: 3856). The University of Alberta has approved the parent portion of the trial (Project ID:00114894). Findings from this study will be disseminated through open-access publications in peer-reviewed journals and using social media.

Trial registration
Clinicaltrials.gov NCT05358990. Registered on May 3, 2022
Long-term impact of paediatric critical illness on the difference between epigenetic and chronological age in relation to physical growth
Authors: Verlinden Ines , Coppens Grégoire , Vanhorebeek Ilse , Güiza Fabian , Derese Inge , Wouters Pieter J. , Joosten Koen F. , Verbruggen Sascha C. , Van den Berghe Greet 
Published: January 2023

AbstractBackgroundAltered DNA-methylation affects biological ageing in adults and developmental processes in children. DNA-methylation is altered by environmental factors, trauma and illnesses. We hypothesised that paediatric critical illness, and the nutritional management in the paediatric intensive care unit (PICU), affects DNA-methylation changes that underly the developmental processes of childhood ageing.ResultsWe studied the impact of critical illness, and of the early use of parenteral nutrition (early-PN) versus late-PN, on “epigenetic age-deviation” in buccal mucosa of 818 former PICU-patients (406 early-PN, 412 late-PN) who participated in the 2-year follow-up of the multicentre PEPaNIC-RCT (ClinicalTrials.gov-NCT01536275), as compared with 392 matched healthy children, and assessed whether this relates to their impaired growth. The epigenetic age-deviation (difference between PedBE clock-estimated epigenetic age and chronological age) was calculated. Using bootstrapped multivariable linear regression models, we assessed the impact hereon of critical illness, and of early-PN versus late-PN. As compared with healthy children, epigenetic age of patients assessed 2 years after PICU-admission deviated negatively from chronological age (p < 0.05 in 51% of bootstrapped replicates), similarly in early-PN and late-PN groups. Next, we identified vulnerable subgroups for epigenetic age-deviation using interaction analysis. We revealed that DNA-methylation age-deceleration in former PICU-patients was dependent on age at time of illness (p < 0.05 for 83% of bootstrapped replicates), with vulnerability starting from 6 years onwards. Finally, we assessed whether vulnerability to epigenetic age-deviation could be related to impaired growth from PICU-admission to follow-up at 2 and 4 years. Multivariable repeated measures ANOVA showed that former PICU-patients, as compared with healthy children, grew less in height (p = 0.0002) and transiently gained weight (p = 0.0003) over the 4-year time course. Growth in height was more stunted in former PICU-patients aged ≥ 6-years at time of critical illness (p = 0.002) than in the younger patients.ConclusionsAs compared with healthy children, former PICU-patients, in particular those aged ≥ 6-years at time of illness, revealed epigenetic age-deceleration, with a physical correlate revealing stunted growth in height. Whether this vulnerability around the age of 6 years for epigenetic age-deceleration and stunted growth years later relates to altered endocrine pathways activated at the time of adrenarche requires further investigation.
Intractable hyponatremia complicated by a reset osmostat: a case report
Authors: Kamel Mohamed Hassan , Upadhyay Ashish , Borkan Steven C. 
Published: January 2023

Abstract
Background
Hyponatremia associated with a low serum osmolality is a common and confounding electrolyte disorder. Correcting hyponatremia is also complicated, especially in the setting of chronic hyponatremia. Here, we provide a rational approach to accurately detecting and safely treating acute on chronic euvolemic hyponatremia in the setting of acute polydipsia with a chronic reset osmostat.

Case presentation
A 71-year-old hispanic gentleman with chronic hyponatremia presented with hiccups, polydipsia, and a serum sodium concentration of 120 mEq/L associated with diffuse weakness, inattentiveness, and suicidal ideation. Symptomatic euvolemic hyponatremia warranted hypertonic saline treatment in the acute phase and water restriction in the chronic phase. Both interventions resulted in improvement in symptoms and/or the serum sodium concentration, but to a serum sodium level that persistently remained below the normal range. Remarkably, the urine osmolality appropriately fell when the serum sodium concentration fell below 126 mEq/L. Also remarkable was the appropriate increase in urine osmolality when the serum sodium concentration exceeded 126 mEq/L. The preservation of both concentration and dilution, albeit at a lower-than-normal serum osmolality, shows that the osmostat regulating antidiuretic hormone release had been “reset.” Both physiologic and pharmacologic resetting of the osmostat are discussed.

Conclusions
Preservation of urinary concentrating and diluting ability at a lower-than-normal serum sodium concentration, especially in the setting of chronic hyponatremia, is diagnostic of a reset osmostat. The presence of a reset osmostat often confounds the treatment of concomitant acute hyponatremia. Early recognition of a reset osmostat avoids the need to normalize serum sodium concentration, expedites hospital discharge, and limits potential harm from overcorrecting acute hyponatremia.
Double-difference earthquake relocation using waveform cross-correlation in Central and East Java, Indonesia
Authors: Muttaqy Faiz , Nugraha Andri Dian , Puspito Nanang T. , Sahara David P. , Zulfakriza Zulfakriza , Rohadi Supriyanto , Supendi Pepen 
Published: January 2023

AbstractThe Central and East Java region, which is part of the Sunda Arc, has relatively high seismic rates due to the convergence of two major tectonic plates in the Indonesian region; i.e., the Indo-Australian Plate subducting under the Eurasian Plate. Many devastating earthquakes have occurred in this area as a result of the interaction between these two plates. Two examples are the 1994 Banyuwangi earthquake (Mw 7.6) and the 2006 Yogyakarta earthquake (Mw 6.3). This study aims to determine precise earthquake locations and analyze the pattern of seismic distribution in Central and East Java, Indonesia. We manually re-picked P and S-wave arrival times that were recorded by the Agency for Meteorology, Climatology and Geophysics (BMKG) of the Indonesian earthquake network during the time period January 2009–September 2017. We then determined the earthquake locations using a non-linear method. To improve the accuracy of the earthquake locations, we relocated 1,127 out of 1,529 events, using a double-difference algorithm with waveform cross-correlation data. Overall, the seismicity in the Central and East Java region is predominantly distributed in the south of Java Island; e.g., the Kebumen, Yogyakarta, Pacitan, Malang, and Banyuwangi clusters. These clusters are probably related to the subduction activity in these regions. Meanwhile, there are clusters of earthquakes having shallow depths on the mainland that indicate the activity of inland faults in the region; e.g., the Opak Fault, the Kendeng Thrust, and the Rembang–Madura–Kangean–Sakala (RMKS) Fault Zone. Several other active inland faults have not shown any significant seismicity over the time period mentioned, i.e., the Pasuruan Fault, the Lasem Fault, the Muria Fault, the Semarang Thrust, and the Probolinggo Fault.
Asymmetric nexus between commercial policies and consumption-based carbon emissions: new evidence from Pakistan
Authors: Chishti Muhammad Zubair , Azeem Hafiz Syed Muhammad , Khan Muhammad Kamran 
Published: January 2023

AbstractThe current study extends the previous literature by exploring the effects of a newly discovered driver, i.e., import taxes (as a proxy for commercial policies), on the consumption-based carbon emissions (CCO2e) for 1990Q1-2017Q4. For empirical analysis, several tests and methods, including Augmented Dickey–Fuller unit root test, Zivot–Andrews unit root test, asymmetric cointegration bound testing approach, non-linear ARDL, Wald-test, Granger causality test and wavelet quantile correlation (WQC) method are utilized. Furthermore, NARDL technique estimates reveal that contractionary commercial policy enhances the environmental quality by disrupting the detrimental effects of CCO2e. However, expansionary commercial policy escalates the environmental pollution by boosting the carbon emissions. Also, the exports and the renewable energy improve the ecological quality; however, GDP deteriorates the atmospheric quality by increasing the CCO2e. Besides, WQC method and the trivariate Granger causality test are deployed to confirm the robustness of the results. Based on the findings, some crucial policies are also recommended for sustainable and green development in Pakistan.