bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of noncoding RNAs in pancreatic birth defects
Authors: Yang Ziyue Zoey , Parchem Ronald J. 
Published: April 2023

AbstractCongenital defects in the pancreas can cause severe health issues such as pancreatic cancer and diabetes which require lifelong treatment. Regenerating healthy pancreatic cells to replace malfunctioning cells has been considered a promising cure for pancreatic diseases including birth defects. However, such therapies are currently unavailable in the clinic. The developmental gene regulatory network underlying pancreatic development must be reactivated for in vivo regeneration and recapitulated in vitro for cell replacement therapy. Thus, understanding the mechanisms driving pancreatic development will pave the way for regenerative therapies. Pancreatic progenitor cells are the precursors of all pancreatic cells which use epigenetic changes to control gene expression during differentiation to generate all of the distinct pancreatic cell types. Epigenetic changes involving DNA methylation and histone modifications can be controlled by noncoding RNAs (ncRNAs). Indeed, increasing evidence suggests that ncRNAs are indispensable for proper organogenesis. Here, we summarize recent insight into the role of ncRNAs in the epigenetic regulation of pancreatic development. We further discuss how disruptions in ncRNA biogenesis and expression lead to developmental defects and diseases. This review summarizes in vivo data from animal models and in vitro studies using stem cell differentiation as a model for pancreatic development.
Analysis of antiplatelet therapy adherence in patients with ischemic cerebral stroke
Authors: Zhong Jie , Gao Yuguang , Huang Deqing , Hu Yueqiang , He Qianchao , Diao Limei , Hu Yuying , Chen Wei 
Published: April 2023

AbstractBackgroundThe related factors affecting the adherence of ischemic cerebral stroke (ICS) patients to antiplatelet therapy have attracted much attention.MethodsPatients with ICS (confirmed by CT or MRI) were enrolled from January 2020 to July 2021. The demographic data were retrospectively investigated and analyzed. The adherence calculation was as follows: Adherence = number of tablets taken/number of tablets needed to be taken. Adherence < 100% was defined as nonadherence. Severe nonadherence is defined as adherence ≤ 75%.ResultsA total of 229 patients with ICS were enrolled. We found no significant difference in the proportion of patients with nonadherence, while the proportion of severe nonadherence in the aspirin group was significantly higher (p < .001). Multivariable analysis indicated that medical insurance (odds ratio [OR] = 0.071, p < .001) and regular exercise (OR = 0.438, p = .015) were independent factors associated with adherence. In addition, only medical insurance (OR = 5.475, p < .001) and aspirin treatment (OR = 0.228, p < .001) were independent risk factors associated with severe nonadherence. We therefore constructed a nomogram plot and a model as follows: Adherence risk score = 3 × medical insurance + regular exercise. Patients were divided into low‐risk and high‐risk groups for adherence based on the median model score. A total of 13.3% of patients in the low‐risk group were nonadherent patients compared with 53.4% in the high‐risk group (p < .001). Similarly, 8.4% of patients in the low‐risk group had severe nonadherence compared with 19.9% in the high‐risk group (p = .022). Moreover, in low‐risk patients, no significant difference was observed. In patients with high risk, aspirin‐treated patients showed significantly decreased adherence compared with the other two groups.ConclusionMedical insurance and regular exercise were independent factors for antiplatelet therapy adherence. For patients with high model scores, timely intervention is necessary.
HMGB1, angel or devil, in ischemic stroke
Authors: Gao Bin , Wang Shuwen , Li Jiangfeng , Han Nannan , Ge Hanming , Zhang Gejuan , Chang Mingze 
Published: April 2023

AbstractIntroductionHigh‐mobility group box 1 protein (HMGB1) is extensively involved in causing ischemic stroke, pathological damage of ischemic brain injury, and neural tissue repair after ischemic brain injury. However, the precise role of HMGB1 in ischemic stroke remains to be elucidated.MethodsComprehensive literature search and narrative review to summarize the current field of HMGB1 in cerebral ischemic based on the basic structure, structural modification, and functional roles of HMGB1 described in the literature.ResultsStudies have exhibited the crucial roles of HMGB1 in cell death, immunity and inflammation, thrombosis, and remodeling and repair. HMGB1 released after cerebral infarction is extensively involved in the pathological injury process in the early stage of cerebral infarction, whereas it is involved in the promotion of brain tissue repair and remodeling in the late stage of cerebral infarction. HMGB1 plays a neurotrophic role in acute white matter stroke, whereas it causes sustained activation of inflammation and plays a damaging role in chronic white matter ischemia.ConclusionsHMGB1 plays a complex role in cerebral infarction, which is related to not only the modification of HMGB1 and bound receptors but also different stages and subtypes of cerebral infarction. future studies on HMGB1 should investigate the spatial and temporal dynamics of HMGB1 after cerebral infarction. Moreover, future studies on HMGB1 should attempt to integrate different stages and infarct subtypes of cerebral infarction.
Continuous and intermittent theta burst stimulation of primary visual cortex do not modulate resting state functional connectivity: A sham‐controlled multi‐echo fMRI study
Authors: Cohan Remy , Rafique Sara A. , Stoby Karlene S. , Gorbet Diana J. , Steeves Jennifer K. E 
Published: April 2023

AbstractIntroduction: Theta burst stimulation (TBS) is a type of rTMS protocol which has the advantage of a shorter delivery time over traditional rTMS. When applied to motor cortex, intermittent TBS (iTBS) has been shown to yield excitatory aftereffects, whereas continuous TBS (cTBS) may lead to inhibitory aftereffects, both lasting from minutes to hours. The majority of TBS research has targeted motor, frontal, and parietal regions, and to date very few studies have examined its efficacy at visual areas. We designed a sham‐controlled study to investigate the immediate poststimulation and short‐term (1 h post‐stimulation) effects of iTBS and cTBS to V1.Methods: Using multiecho functional magnetic resonance imaging, we measured the direct and indirect effects of TBS by comparing resting state functional connectivity (FC) before and after stimulation in whole brain networks, and seeds from V1 (stimulation site) and neighboring occipital and parietal visual networks. In addition, we also measured pre‐ and post‐TBS phosphene thresholds (PTs) to examine the modulatory effects of TBS on cortical excitability.Results: We found no changes in FC for iTBS, cTBS or sham stimulation conditions from baseline to poststimulation timepoints. Additionally, cTBS and iTBS had no effect on visual cortical excitability.Conclusions: Our results indicate that unlike our previous low frequency rTMS to V1 study, which resulted in widespread FC changes up to at least 1 h after stimulation, TBS to V1 does not affect FC. Contrary to the studies showing comparable TBS and rTMS aftereffects in motor and frontal regions, our findings suggest that a single session of cTBS or iTBS to V1 at 80% PT using a standard protocol of 600 pulses may not be effective in targeting FC, especially in clinical settings where therapy for pathological networks is the goal.
Recognizing schizophrenia using facial expressions based on convolutional neural network
Authors: Zhang Xiaofei , Li Tongxin , Wang Conghui , Tian Tian , Pang Haizhu , Pang Jisong , Su Chen , Shi Xiaomei , Li Jiangong , Ren Lina , Wang Jing , Li Lulu , Ma Yanyan , Li Shen , Wang Lili 
Published: April 2023

AbstractObjectiveFacial expressions have been served as clinical symptoms to convey mental conditions in psychiatry. This paper proposes to recognize patients with schizophrenia (SCZ) using their facial images based on deep learning algorithm, and to investigate objective differences in facial expressions between SCZ patients and healthy controls using deep learning algorithm and statistical analyses.MethodsThe study consists of two parts. The first part recruited 106 SCZ patients and 101 healthy controls, and videotaped their facial expressions through a fixed experimental paradigm. The video data were randomly divided into two sets, one for training a convolutional neural network (CNN) with the classification of “healthy control” or “SCZ patient” as output and the other for evaluating the classification result of the trained CNN. In the second part, all facial images of the recruited participants were put into another CNN separately, which was priorly trained with a facial expression database and will output the most likely facial expressions of the recruited participants. Statistical analyses were performed on the obtained facial expressions to find out the objective differences in facial expressions between the two recruited groups.ResultsThe trained CNN achieved an overall accuracy of 95.18% for classifying “healthy control” or “SCZ patient.” Statistical results on the obtained facial expressions demonstrated that the objective differences between the two recruited groups were statistically significant (p < .05).ConclusionsFacial expressions hold great promise as SCZ clues with the help of deep learning algorithm. The proposed approach would be potentially applied to mobile devices for autorecognizing SCZ in the context of clinical and daily life.
Corporate Nirvana: The Buddhist way to social sustainability and business innovation
Authors: Sharma Daneshwar , Sahoo Saumyaranjan , Kumar Ashwani , Huisingh Donald , Sharma Dheeraj 
Published: April 2023

AbstractPrevailing consumption‐based business models and capitalist practices place significant strain on the environment and society. Buddhism, as a practicing religion, may provide insights on practicing models as a solution to sustain society, the environment, and businesses. The present investigation adopts a structured literature review methodology to take stock of such prior studies and articulate its representation of Buddhism‐based business models, practices, ethical frameworks, and economic views. Based on the findings, it is clear that the prior studies have discussed the practitioner context of Buddhism religion in order to promote ethical and mindful business practices at the consumer, managerial, and business levels; to reduce the negative effects of identity politics in the workplace through spirituality; to introduce the idea of considering factors other than purely financial profitability; and to encourage the long‐term viability and genuine happiness of individuals, communities, and organizations. In relation to these topics, research avenues are proposed.
What was yours is (for now) mine: Prior user knowledge reduces product satisfaction but can improve experiential satisfaction in access‐based consumption
Authors: Stough Rusty Allen , Carter Erin Percival 
Published: April 2023

AbstractWith the rise of the sharing economy, more consumers than ever are thinking about products not in terms of ownership, but in terms of access necessary to facilitate experiences. In this paper, we build on prior literature, which distinguished product from experiential satisfaction to explore the role that knowledge of a prior user plays in shaping these two types of satisfaction in access‐based consumption experiences. Across three studies, we demonstrate that product and experiential satisfaction can be affected differently when consumers are provided with information about previous users of products. We find that information about the previous user of a product consistently negatively impacts product satisfaction. However, we find that when the previous user has positive and experientially relevant traits, experiential satisfaction is increased. When the information about the previous user is negative or experientially irrelevant, experiential satisfaction is decreased. In cases in which we find a positive effect of prior user information on experiential satisfaction, we find it is mediated by transfer of the previous user's traits and that the effectiveness of this mechanism depends on the relevance of traits and the stability of the self‐concept of the consumer.
Emodin‐Induced Necroptosis in Prostate Cancer Cells via the Mitochondrial Fission HSP90/MLKL/PGAM Pathway
Authors: Zhou Xi , Yeasmin Khusbu Farjana , Xie Yang , Yang Peng 
Published: April 2023

AbstractCurrently, prostate cancer is one of the major malignant tumors in males. Recurrence and metastasis are the main obstacles that prevent the effective treatment of prostate cancer. In the present study, we aimed to evaluate emodin (EG) against human prostate cancer PC3 and DU145 cells. Our study showed that EG significantly decreased the cell viability of PC3 and DU145 cells and strikingly induced non‐apoptotic cell death via necroptosis that was visualized through colony formation assay, Hoechst 33258 staining, and TEM analysis. Furthermore, RNA‐sequencing and KEGG functional enrichment analysis revealed that the necroptosis‐related pathway was activated upon EG treatment in PC3 cells. mRNA and protein expression of necroptosis markers were analyzed by qPCR and immunoblotting, which implied that EG‐induced cell necroptosis via enhancing the expression of MLKL and HSP90AA1 activating PGAM pathway which is considered as a key mediator of mitochondrial fission and leading to ROS generation in PC3 and DU145 cells. Thus, our findings suggested that EG is a new small molecule agonist that induced necroptosis in prostate cancer cells via the mitochondrial fission HSP90/MLKL/PGAM pathway.
22‐Oxocholestanes SPGP4 and SPGP8: in Silico and in Vitro Study as Activators of Plant Growth Promotion
Authors: Balbuena‐Hernández Luis , Miranda‐Arámbula Mariana , Merino‐Montiel Penélope , Carrasco‐Carballo Alan , Sandoval‐Ramírez Jesús 
Published: April 2023

AbstractThe 22‐oxocholestanes compounds have shown an outstanding plant growth promoting activity; they have similar bioactivity as brassinosteroids, so they are normally named as brassinosteroid analogs thinking that they also impact on the known receptor BRI1. However, in silico studies allow us to predict interactions with other receptors and thus it's possible to evaluate them, through receptors of gibberellins, auxins, jasmonates, strigolactones and the protein associated with the BRI1 gene. This article describes the bioactivity of structures SPGP4 and SPGP8 as plant growth‐promoting compounds. Both structures present coupling energies and interactions at the same level as epibrassinolide in the protein associated with BRI1 gene. Additionally, interactions through the auxin pathway and to strigolactone receptor were found using selected tests. In the rice lamina tilt, a higher effect was obtained when SPGP4 and SPGP8 were compared to epibrassinolide, although in a lesser level vis à vis to homobrassinolide. In the same way, when SPGP4 and SPGP8 were tested in the Growth Root Model an activity as strigonolactones was observed, enhancing the relationship between the main and secondary roots. However, the growth of coleptiles, when applying auxins, compounds SPGP4 and SPGP8 did not reach the same level as controls. In the tests associated to gibberellins and jasmonic acid, an increased bioactivity was observed, although this behavior was not reflected from the in silico study, possibly due to secondary signaling cascades. This work demonstrates that the 22‐oxocolestane compounds SPGP4 and SPGP8 could be used as plant growth hormones, promoting several pathways.
limpca: An R package for the linear modeling of high‐dimensional designed data based on ASCA/APCA family of methods
Authors: Thiel Michel , Benaiche Nadia , Martin Manon , Franceschini Sébastien , Van Oirbeek Robin , Govaerts Bernadette 
Published: April 2023

SummaryMany modern analytical methods are used to analyze samples issued from an experimental design, for example, in medical, biological, chemical, or agronomic fields. Those methods generate most of the time, highly multivariate data like spectra or images, where the number of variables (descriptor responses) tends to be much larger than the number of experimental units. Therefore, multivariate statistical tools are necessary to identify variables that are consistently affected by experimental factors. In this context, two recent methods combining ANOVA and PCA, namely, ASCA (ANOVA‐Simultaneous Component Analysis) and APCA (ANOVA‐Principal Component Analysis), were developed. They provide powerful visualization tools for multivariate structures in the space of each effect of the statistical model linked to the experimental design. Their main limitation is that they produce biased estimators of the factor effects when the design of experiment is unbalanced. This article presents the R package limpca (for linear models with principal component effects analysis) that implements ASCA+ and APCA+, an enhanced version of ASCA and APCA methods based on several principles from the theory of general linear models (GLM). In this paper, the methodology is reviewed, the package structure and functions are presented, and a metabolomics data set is used to clearly demonstrate the potential of ASCA+ and APCA+ methods to highlight true biomarkers corresponding to effects of interest in unbalanced designs.
Electron‐Rich MoIV3‐Polyoxomolybdates Resembling the Paratungstic Archetype
Authors: Cheng Cheng , Yi Xiaofeng , Chen Weipeng , Sang Ruili , Xu Li 
Published: April 2023

AbstractThe first polyoxometalates (POMs) composed of MoIV, MoV2, discrete d1‐MoV and MoVI, [MoIV3MoV6MoVI4O32(μ2‐OH)(μ3‐OH)py9] (1), was prepared from the solvothermal partial oxidation of [MoIV3O2(O2CCH3)6(H2O)3]ZnCl4 in a mixture of pyridine and water. The MoV=O adduct‐free unit [H2Mo12O33py9] presents the 11e‐reduced Mo derivative of the paratungtic archetype. The use of methanol, ethanol, n‐propyl alcohol and triglycol instead of water produced the isostructural [MoIV3MoV6MoVI4O32(μ3‐OH)(μ2‐OR)py9](R=CH3, 2; C2H5, 3; C3H7, 4; C2H4OH, 5), providing the first examples of MoIV3−POMs containing bridging alkoxyl groups. The addition of [CrIIIMo6O24]9− led to the substitution of {MoV=O}3+ with {CrIII‐py}3+ in the allomer [MoIV3MoV5MoVI4CrIIIO32(μ‐OH)2py10] (6). Using a mixture of Mo3 and MoW2 precursors afforded WVI‐incorporated allomer [MoIV3MoV6MoVIWVI3O32(μ‐OH)2py9] (7). The complete substitution of MoVI with WVI by using a mixture of the Mo2W, MoW2 and W3 precursors produced the diamagnetic [MoIV3MoV6WVI4O33(μ3‐OH)py9]− (syn‐8) resulting from the anti→syn conversion between the top and bottom M3 triads concomitant with MoV‐MoV bonding. Both anti‐1‐7 and syn‐8 have been characterized by X‐ray single crystal structural analyses. The spin distribution and magnetic interactions have been investigated by temperature‐dependent magnetic susceptibility and DFT theoretical calculations. Heterogeneous hydrogen transfer catalysis has been examined by the Lewis catalysis field (LCF) theory.
Defluorination of Fluorophenols by a Nonheme Iron(IV)‐Oxo Species: Observation of a New Intermediate Along the Reaction
Authors: Bagha Umesh Kumar , Yadav Rolly , Mokkawes Thirakorn , Satpathy Jagnyesh Kumar , Kumar Devesh , Sastri Chivukula V. , de Visser Sam P. 
Published: April 2023

AbstractHigh‐valent iron(IV)‐oxo intermediates are versatile oxidants in the biotransformation of various substrates by metalloenzymes and catalyze essential reactions for human health as well as in the biodegradation of toxic organic pollutants in the environment. Herein, we report a biomimetic system that efficiently reacts with halophenols through defluorination reactions and characterize various short‐lived intermediates along the reaction mechanism. We study the reactivity pattern of a nonheme iron(IV)‐oxo species with a series of trihalophenols (X=F, Cl, Br). A combined experimental and computational study reveals that the oxidative dehalogenation of 2,4,6‐trifluorophenol is initiated with an H‐atom abstraction from the phenolic group by the iron(IV)‐oxo species resulting in the formation of a phenolate radical and an iron(III)‐hydroxo species. This iron(III)‐hydroxo species forms an adduct with the oxidized substrate with λmax at 558 nm which subsequently decays to give quinones as products.
A pH‐ and Metal‐Actuated Molecular Shuttle in Water
Authors: Kriat Amine , Pascal Simon , Kauffmann Brice , Ferrand Yann , Bergé‐Lefranc David , Gigmes Didier , Siri Olivier , Kermagoret Anthony , Bardelang David 
Published: April 2023

AbstractThe structure of the Viologen‐Phenylene‐Imidazole (VPI) guest, previously shown to be bound by cucurbit[7]uril (CB[7]) with binding modes depending on pH and silver ions, has been extended by adding hydrophobic groups on the two extremities ofVPIbefore investigations of CB[7] binding by NMR, ITC, X‐ray diffraction, UV‐vis and fluorescence spectroscopies. With an imidazole station extended by a naphthalene group (VPI‐N), binding modes of CB[7] are similar to those previously observed. However, with the viologen extended by a tolyl group (T‐VPI), CB[7] preferentially sits on stationT, shuttling between theTandPstations at acid pH or after Ag+addition. The CB[7] ⋅ T‐VPIcomplex thus behaves as a metal‐actuated thermodynamicstop‐and‐gomolecular shuttle featured by fast and autonomous ring translocation between two stations and a continuum for fractional station occupancy solely and easily controlled by Ag+concentration.
The Impact of the Solvent Dielectric Constant on A←NH3Dative Bond Depends on the Nature of the Lewis Electron‐Pair Systems
Authors: Manna Debashree , Lo Rabindranath , Nachtigallová Dana , Trávníček Zdeněk , Hobza Pavel 
Published: April 2023

AbstractThe present work aims to determine to what extent the value of the dielectric constant of the solvent can influence the dative bond in Lewis electron pair bonding systems. For this purpose, two different systems, namely H3B←NH3and {Zn←(NH3)}2+, were studied in selected solvents with significantly different dielectric constants. Based on the results from state‐of‐the‐art computational methods using DFT, constrained DFT, energy decomposition analyses, solvent accessible surface area, and charge transfer calculations, we found that the stability of the neutral H3B←NH3system increases with increasing solvent polarity. In contrast, the opposite trend is observed for the positively charged {Zn←(NH3)}2+. The observed changes are attributed to different charge redistributions in neutral and charged complexes, which are reflected by a different response to the solvent and are quantified by changes in solvation energies.
UV‐Blocking and Light‐Responsive Poly (ϵ‐Caprolactone)/ZIF‐8 Multifunctional Composite Films for Efficient Antibacterial Activities
Authors: Wang Cuijuan , Feng Siwen , Tang Hongwen , Tan Lichuan , Fan Shuyan , Sun Zeyu , Han Xinping 
Published: April 2023

AbstractAntibacterial photodynamic therapy (APDT) has received considerable attention owing to its superiority. ZIF‐8 was used to address the poor stability of the photosensitizer Rose Bengal (RB) encapsulation to synthesize RB@ZIF‐8 NPs, which were doped into a composite film with poly (ϵ‐caprolactone) (PCL) and polyvinyl alcohol‐quaternary ammonium chitosan (PVA‐QCS) as substrates to form composite films (PQZ). The composite films exhibited excellent photodynamic sterilization and good resistance to bacterial adhesion. The tensile strength of the film increased to 43.4 MPa, which was approximately 1.8 times that of the PCL film. With the addition of SiO2 and RB@ZIF‐8 NPs, the film exhibited water repellency and UV‐blocking properties. RAW264.7 cells were selected using the MTT method to confirm that the composite films had excellent biocompatibility and had no significant inhibitory effect on cell growth and reproduction. PQZ multifunctional composite films show potential as novel APDT antimicrobial materials for food packaging.