bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecotoxicological Studies Indicate That Sublethal and Lethal Processes Limit Insect-Mediated Contaminant Flux
Authors: Olson Connor I. , Beaubien Gale B. , Otter Ryan R. , Walters David M. , Mills Marc A. 
Published: January 2023

Abstract
Merolimnic insects can accumulate and transport considerable amounts of aquatic contaminants to terrestrial systems. The rate of contaminant biotransport, termed insect-mediated contaminant flux (IMCF), depends on emergent insect biomass and contaminant accumulation, both functions of environmental concentration. We developed a mathematical model of IMCF and apply it to three ecotoxicological studies obtained through the US Environmental Protection Agency's ECOTOX database to determine at which concentration maximum IMCF occurs. Model results demonstrate that the maximum IMCF depends on competing rates of biomass loss and contaminant accumulation and does not necessarily occur at the highest insect or environmental contaminant concentration. In addition, modeling results suggest that sublethal contaminant effects (e.g., decreased growth) on insect biomass can be an important and potentially underappreciated control on IMCF. Environ Toxicol Chem 2023;42:1982–1992. © 2023 SETAC. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Impact of human telomerase reverse transcriptase peptide vaccine combined with androgen deprivation therapy and radiotherapy in de novo metastatic prostate cancer: Long‐term clinical monitoring
Authors: Lilleby Wolfgang , Seierstad Therese , Inderberg Else Marit , Hole Knut Håkon 
Published: January 2023

AbstractProstate cancer is considered as poorly immunogenic. In a phase I/II study on de novo metastatic prostate cancer we found that a human telomerase reverse transcriptase (hTERT) vaccine induced an early immune response in most of the patients. Here we present the results from the long‐term monitoring of the immune responses and clinical outcomes. Twenty‐two men with ISUP 4 to 5 and lymph node and/or bone metastases were treated with androgen deprivation therapy (ADT), radiotherapy and the hTERT vaccine UV1 between January 2013 and July 2014. Immune response was monitored before, during and after vaccination and continued every 6 months until PSA progression. All patients had magnetic resonance imaging (MRI) at baseline, and after 6 months, 1 and 2 years, and at progression. The clinical outcome was time to progression, overall survival and prostate cancer‐specific survival. The median follow‐up was 62 months (range: 19‐101). At the last observation, nine of the 22 patients were still alive. Six have no progression, two have castration‐resistant disease treated with second‐line ADT and one has castration‐refractory disease. Median time to PSA progression was 21 months, median overall survival was 62 months and median prostate cancer‐specific survival was 84 months. Lack of immune response was an independent marker of prostate cancer death. The long‐term monitoring showed that some patients had unanticipated subsequent high immune responses without developing recurrence. This association indicates that there might be a clinical benefit of hTERT vaccination in a subgroup of men with primary metastatic hormone‐sensitive prostate cancer treated with ADT and radiotherapy.
Varying reinforcer dimensions during differential reinforcement without extinction: A translational model
Authors: Iannaccone Julia A. , Jessel Joshua 
Published: January 2023

AbstractProcedural arrangements of differential reinforcement of alternative behavior without extinction often involve presenting the same reinforcers for problem behavior and appropriate behavior, which is typically ineffective at reducing problem behavior and increasing an alternative response. However, manipulating reinforcement dimensions such that the contingencies favor the alternative response may improve treatment outcomes when using differential reinforcement of alternative behavior without extinction by increasing appropriate behavior and reducing problem behavior. We conducted this translational study with 32 college students completing a button‐pressing task on a computer program in which they could engage in analogs to problem behavior and appropriate behavior. The effects of manipulating magnitude, immediacy, quality, and a combination of all three dimensions for the alternative response were evaluated. Overall, all dimension manipulations reduced the analog to problem behavior, with the largest reductions observed during the quality probe and the probe with all dimensions combined. These results support the notion that differential reinforcement of alternative behavior without extinction can be an effective form of treatment.
Ultrasound findings and prognosis of shoulder pain: A role for Doppler signal?
Authors: Janeiro João , Barreira Sofia , Martins Patrícia , Sarmento Marco , Campos Jorge , Fonseca João Eurico 
Published: January 2023

AbstractPurposeTo find ultrasound prognostic factors for shoulder pain.MethodsThis was an observational, prospective study, comparing the evolution of ultrasound findings with clinical outcomes, in patients with shoulder pain. Data were collected in two appointments, from February 2018 to March 2021. Two‐tailed non‐parametric statistics were used, and p values <0.05 were considered significant.ResultsA total of 79 participants were included in this study (median age 59 years, range 24–70, 61 women). A positive Doppler signal on tendons (p = 0.002) and absent tendon heterogeneity (p = 0.01) were associated with the patient's self‐reported improvement. Tendon calcifications with poorly defined contours (p = 0.03) and sparse distribution (p = 0.001) were associated with VAS improvement. A reduction in the number of calcifications (p = 0.004), in the supraspinatus tendon thickness (p = 0.01), in subacromial effusions (p = 0.03), and in color Doppler grade (p = 0.02), between initial and follow‐up exams, was found in patients with an improved DASH outcome.ConclusionA positive Doppler signal on shoulder tendons can be a marker for a better prognosis in shoulder pain. Poorly defined and sparsely distributed calcifications can also indicate a better course of the disease.
Elevated levels of anthropogenic antibiotic resistance gene marker, sul1, linked with extreme fecal contamination and poor water quality in wastewater‐receiving ponds
Authors: Gunjyal Neelam , Singh Gargi , Ojha Chandra Shekhar Prasad 
Published: January 2023

AbstractIn several low‐ and middle‐income countries, such as India, the rapid construction of toilets to combat open defecation has not been matched with adequate wastewater treatment, resulting in extreme fecal contamination of the receiving environments. The sewage‐receiving surface water bodies, typically close to the residences, are a potential hotspot for disease transmission and antibiotic resistance. Water, soil, and sediment samples from seven wastewater‐receiving ponds (WRPs) were analyzed for water quality, chlorophyll‐a, fecal contamination (yccT for Escherichia coli), 16S rRNA gene copies, and anthropogenic antibiotic resistance gene markers—sul1 and intI1. These WRPs were contrasted with two ponds that did not directly receive sewage. The water quality in the WRPs was comparable to raw sewage (BOD: 210–380 mg/L; COD: 350–630 mg/L; total‐N: 100–190 mg/L; and total‐P: 6–21 mg/L), and the relative levels of the DNA marker of E. coli were very high (yccT: 0.1% to ∼100% of total bacterial count) indicating extreme fecal contamination. The relative levels of sul1 and intI1 were 1–3 orders of magnitude higher in WRPs (sul1: 0.32%–10% of total bacterial count; and intI1: 0.2%–5% of total bacterial count) compared to the ponds that did not receive sewage directly. The relative levels of sul1 correlated with the DNA marker for the fecal indicator, E. coli (p‐value < 0.05; r = 0.50; Spearman's rank correlation), and poor water quality.
Moisture sorption isotherms characteristics for shelf‐life prediction of peanuts (Arachis Hypogaea L.)
Authors: Kaur Gurjeet , Sidhu Gagandeep Kaur , Kaur Preetinder 
Published: January 2023

AbstractBACKGROUNDThe spring grown peanut varieties J87 and TG37A are prone to quality deterioration as a result of high temperature and relative humidity during harvesting. Thus, the sorption isotherms of peanut varieties were evaluated at 25, 35 and 45 °C and the water activity (aw) range of 0.110–0.975 aiming to predict the suitable storage conditions, packaging material and shelf‐life.RESULTSThe equilibrium moisture content (EMC) increased with increased aw and isotherms of type II were observed. The monolayer moisture content varied between 3.135% and 4.235% for J87 and between 3.906% and 5.640% for TG37A variety. The experimental data were fitted to seven mathematical models. The variations in correlation coefficients were in the range 0.879–0.992 and in root mean square were in the range 0.055–1.988. On the basis of statistical parameters, Guggenheim Anderson de Boer and Double Log Polynomial were considered to be best fitted models. At aw of 0.6, critical moisture content (CMC) was 7.59%, 7.060% and 5.89% for J87 and 9.06%, 8.904% and 7.80% for TG37A at 25, 35 and 45 °C, respectively. The shelf‐life prediction model provided that the aluminum packages had the maximum predicted shelf‐life of around 1779 days for TG37A and 1077 days for J87 variety at 25 °C with an initial moisture content of 5.91% and 4.81%, respectively.CONCLUSIONThe EMC and CMC evaluated from sorption study provided the basis for determination of package properties and shelf life. Aluminum packages had the minimum water vapor transmission rate and permeability. Hence, peanuts packaged in these bags and stored at 25 °C and 75% relative humidity had the potential to attain the maximum storage life. © 2023 Society of Chemical Industry.
Effect of tea catechins on gut microbiota in high fat diet‐induced obese mice
Authors: Liu Jianhui , Ding Huafang , Yan Chi , He Zouyan , Zhu Hanyue , Ma Ka Ying 
Published: January 2023

AbstractBACKGROUNDTea catechins have been shown to have beneficial effects on the alleviation of obesity, the prevention of diabetes, and the amelioration of metabolic syndrome. The purpose of the present work is to explore the underlying mechanisms linking the intestinal microbiota and anti‐obesity benefits of green tea, oolong tea, and black tea catechins in C57BL/6J mice fed with a high‐fat diet (HFD).RESULTSThe results indicated that, after the dietary intake of three tea catechins, obesity and low‐grade inflammation were significantly alleviated. Hepatic steatosis was prevented, and this was accompanied by the upregulation of the mRNA and protein expressions of hepatic peroxisome proliferator‐activated receptor α (PPARα). Metagenomic analysis of fecal samples suggested that the three tea catechins similarly changed the microbiota in terms of overall structure, composition, and protein functions by regulating the metabolites, facilitating the generation of short‐chain fatty acids (SCFAs), and repressing lipopolysaccharides.CONCLUSIONThe anti‐obese properties of three tea catechins were partially mediated by their positive effect on gut microbiota, hepatic steatosis alleviation, and anti‐inflammatory activity. © 2023 Society of Chemical Industry.
Nano‐biochar: Properties and prospects for sustainable agriculture
Authors: Shafiq Fahad , Anwar Sumera , Firdaus‐e‐Bareen  , Zhang Lixin , Ashraf Muhammad 
Published: January 2023

AbstractBiochar is an extremely valuable carbon black material used since the Pre‐Columbian Era in Latin America and is known for its properties to promote soil fertility and sustain crop production. Modern civilization has followed the footsteps of ancient civilizations and has prepared nano‐sized biochar (nano‐BC). The synthesis of nano‐BC can be achieved using different feedstock materials via pyrolysis, yielding bulk‐BCs which are mechanical transformed into the nano‐BCs, the final value‐added product. This review provides insights into structural, functional, and elemental properties concerning synthesis, surface properties including functional groups, and carbon stability. Moreover, the prospects of improving soil physicochemical properties including CEC, nutrient availability, soil water retention, and buffering capacity are discussed with agricultural implications. Mechanistic insights have been provided regarding how nano‐BC can improve soil health and could promote plant growth and physio‐biochemical properties, which further pave the way for its application to improve plant resilience to abiotic stress factors. Last, limited studies have been conducted that elucidate potential negative effects including contaminant mobilization and residual effects and these are also critically discussed. Above all, nano‐BC could be used as a beneficial soil amendment to boost crop production and enhance soil fertilities.
Iranian nursing applicants' perception of the nursing profession: A qualitative study
Authors: Zamanzadeh Vahid , Ghahramanian Akram , Valizadeh Leila , Bagheriyeh Farzaneh 
Published: January 2023

AbstractAimThis study was conducted to describe the perceptions of nursing applicants about their chosen profession and to explore the factors which influenced their understanding.DesignA qualitative study with a conventional content analysis design.MethodsParticipants were 19 nursing applicants enrolling in nursing schools in three provinces of western Iran. Data were collected using semi‐structured interviews. The content analysis of the interviews was done according to the steps proposed by Zhang and Wildemuth.ResultsThe mean age of participants was 20 years (SD = 2.5), and 11 of them (57.9%) were females. Participants understood the nature of nursing work to encompass only a limited level of independence; they viewed it as a feminine profession, and as a job with spiritual rewards. The perceived content of nursing work included providing help and patient care in the hospital with a focus on performing procedural tasks. Applicants' perceptions of nurses' characteristics included strong physical endurance, communication skills, emotional strength and low intellectual skills. The professional status of nursing was perceived simultaneously as having high job security but limited potential for career advancement and professional growth. The factors reported to influence applicants' perceptions were related to the media, academic–career counsellors, personal factors, and family and friends.
Effect of yhfS gene on Bt LLP29 antioxidant and UV ray resistance
Authors: Liu Xihua , Zhang Yile , Du Xi , Luo Xingyu , Tan Weilong , Guan Xiong , Zhang Lingling 
Published: January 2023

AbstractBACKGROUNDBacillus thuringiensis (Bt) is a widely used microbial insecticide. However, its persistence is limited because of ultraviolet (UV) rays or other environmental factors. The yhfS gene, which encodes acetyl‐CoA acyltransferase, plays an important role in lipid transport and metabolism in many organisms. To explore whether it is related to the stress resistance of Bt LLP29, the yhfS gene knockout strain LLP29 Δ‐yhfS and the complementary strain LLP29 R‐yhfS were generated successfully by homologous recombination technology, and the related phenotypic changes were compared in this study.RESULTSGene yhfS was found to be functional in response to UV radiation in Bt by comparing the survival rates of Bt LLP29 harboring yhfS or not under UV light. Enzyme activity assays of key enzymes showed the the Embden–Meyerhof–Parnas pathway was enhanced yet the tricarboxylic acid cycle as well as butanoate synthesis were repressed when the gene was deleted. At the same time, the amino acid content was decreased, but reduced nicotinamide adenine dinucleotide (NADH) and reactive oxygen species (ROS) content were increased. Most noteworthy, antioxidase (such as superoxide dismutase and peroxidase) activities and contents of some potent antioxidants (such as pyruvate, carotenoids and NADPH) were lower in LLP29 Δ‐yhfS than in LLP29.CONCLUSIONThese tests revealed that the loss of the yhfS gene led to metabolic disorders and reduction of the antioxidant ability of Bt. Higher ROS level and lower anti‐oxidative capacity might be responsible for the reduced UV resistance when the gene was deleted. These results not only greatly enrich understanding of the mechanism of Bt UV resistance, but also provide an important theoretical basis for Bt application. © 2023 Society of Chemical Industry.
The weak ligand field in lanthanoid(III) hydrogensulfate‐sulfates
Authors: Hein Sebastian , Jähnig Maximilian , Kannengießer Nils , Pape Jonathan , Laporte Tobias , Schnakenburg Gregor , Kremer Reinhard K. , Urland Werner , Glaum Robert 
Published: January 2023

AbstractThe hydrogensulfate‐sulfates Ln(HSO4)(SO4) (Ln: Sm, Eu, Gd, Tb, Dy) have been crystallized from sulfuric acid and their thermal decomposition behavior has been studied. The crystal structures for all members of the series were refined from X‐ray single‐crystal diffraction data (for all: Tb(HSO4)(SO4) structure type, P21, Z=2, a≈6.66 Å, b≈6.63 Å, c≈6.82 Å, β≈104.6°). Optical spectra (Sm–Dy) and magnetic susceptibilities (Eu–Dy) have been measured. For comparison the octahydrates Ln2(SO4)3 ⋅ 8 H2O (Sm, Eu) and the anhydrous sulfates Ln2(SO4)3 (Sm, Eu) have also been characterized by optical spectroscopy and magnetic measurements. Ligand field analyses (angular overlap model) based on these data suggest for the square‐antiprismatic [LnIIIO8] chromophores in the hydrogensulfate‐sulfates a rather weak ligand field, which is comparable only to that in ultraphosphates LnP5O14 and in contrast to the much stronger field observed for most other lanthanoid(III) oxo‐compounds studied so far.
Die Entwicklung der psychischen Gesundheit bei hochaltrigen Individuen während der COVID-19-Pandemie und die Rolle sozialer Unterstützung
Authors: Gerhards Sina K. , Pabst Alexander , Riedel-Heller Steffi G. , Luppa Melanie 
Published: January 2023

Zusammenfassung
Hintergrund
Die Bevölkerungsgruppe der Hochaltrigen gehört zu den Hochrisikogruppen in Bezug auf einen schweren Erkrankungsverlauf und erhöhte Mortalität bei Ansteckung mit dem Coronavirus SARS-CoV-2 (engl.: Severe Acute Raspiratory Syndrom Coronavirus 2). Sie ist durch die COVID-19-Pandemie selbst, aber auch durch Maßnahmen des Gesundheitsschutzes möglicherweise einem höheren Risiko für psychische Belastung ausgesetzt. Es soll untersucht werden, wie sich Symptomatiken von Depressivität, Ängstlichkeit und Somatisierung im Verlauf der Pandemie verändern und welche Rolle die soziale Unterstützung dabei spielt.

Methoden
Mittels zweier schriftlicher Befragungen von n = 156 Hochaltrigen in den Zeiträumen Mai bis Juni 2020 sowie März bis Mai 2021 wurden neben soziodemografischen Daten Faktoren der psychischen Belastung (Depressivität, Ängstlichkeit, Somatisierung) sowie die wahrgenommene soziale Unterstützung erfasst. Das mittlere Alter der Befragten betrug 87,20 Jahre (SD = 4,65; Altersspanne = 77,68–96,75 Jahre; 2020) bzw. 88,03 Jahre (SD = 4,63; Altersspanne = 78,52–97,62; 2021). Die Daten wurden mittels Wilcoxon-t-Tests und generalisierter linearer Regressionsmodelle analysiert.

Ergebnisse
Es lässt sich eine signifikante Zunahme der Ausprägung psychischer Belastung hinsichtlich Depressivität, Ängstlichkeit und Somatisierung erkennen. Höhere Werte der psychischen Belastung im Jahr 2020 sind mit einer höheren psychischen Belastung im Jahr 2021 assoziiert. Eine stärkere wahrgenommene soziale Unterstützung im Jahr 2020 ist mit geringerer Depressivität ein Jahr später assoziiert.

Schlussfolgerung
Bei hochaltrigen Menschen ist im Verlauf der COVID-19-Pandemie bis Mai 2021 eine Zunahme der psychischen Belastung zu verzeichnen. Sie sollten durch präventive Angebote unterstützt werden, um einer weiteren Zunahme der Symptomatik vorzubeugen. Der Ausbau von sozialer Unterstützung könnte v. a. bei der Prävention depressiver Symptomatik sinnvoll sein.
Geometric-kinematic model for reinforced concrete core drilling
Authors: Marra Lucas , Fabbro Stefan , Kuffa Michal , Wegener Konrad 
Published: January 2023

AbstractSince diamond-impregnated tools have a big share on tools for construction, the development of more efficient ones is necessary in the near future. The drilling speed performance is one of the concerns during the development of new diamond-impregnated segments in concrete core drilling. However, observations only based on experiments can be very costly, considering a quite demanding amount of material and workforce. One of the solutions to overcome these issues is the development of a geometric-kinematic model (containing a kinematic process model, material model, and drilling force model) to simulate the tangential and normal forces of diamond-impregnated segments in core drilling process. Such model is regularly used in the literature for the simulation of a bonded-abrasives process. The main purpose of the geometric-kinematic model is to generate simulations for the concrete core drilling for the tool performance estimation. This allows an evaluation of the geometric characteristics’ (diamond morphology, orientation, size, and positioning) impact of diamond-impregnated segments and of drilling parameters on the drilling force. The geometric-kinematic model will use detailed segment descriptions with stochastic and deterministic variables. The drilling simulation delivers a consistent drilling forces prediction in Utliberg concrete and ASTM A615 steel at the frequently used core drilling feed window. Besides, the model shows the competence to evaluate the impact of a diamond layer characteristics (diamond size and number of rows), allowing the comparison of distinct diamond arrangements designs between each other.
Infectious complications during monoclonal antibodies treatments and cell therapies in Acute Lymphoblastic Leukemia
Authors: Quattrone Martina , Di Pilla Alessia , Pagano Livio , Fianchi Luana 
Published: January 2023

AbstractInfections represent one of the most frequent complications during the treatment of patients with Acute Lymphoblastic Leukemia (ALL): of these, almost half develop an infectious event in the majority of cases in induction. The new monoclonal and bispecific antibodies and CAR-T, besides offering new perspectives in the overall survival and disease-free survival of patients, may also transform the epidemiology of infections in ALL by improving the toxicity of treatments. In this review, we examined studies published in the literature over the past 12 years and described the infectious complications of therapy with Blinatumomab, Inotuzumab, Rituximab and CAR-T in adult and pediatric patients with ALL. Infections are less frequent than in traditional chemotherapy treatment with vincristine, corticosteroids and anthracyclines, which has been the backbone of therapy for patients with ALL for years. On the other hand, the infection scenario in the CAR-T setting is quite peculiar: In these patients, infections are more frequent in the first month after infusion and are predominantly bacterial. As the time moves away from day zero, viral infections become more frequent, occurring mainly in patients who have had prolonged cytopenia and major cytokine release syndrome.