bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and enablers influencing female athlete return-to-sport postpartum: a scoping review
Authors: Tighe Boden Joel , Williams Susan L , Porter Courtney , Hayman Melanie 
Published: September 2023

ObjectiveMotherhood within sport has become more common with many female athletes seeking to return-to-sport (RTS) postpartum; yet few sport organisations possess policies that support female athletes to RTS postpartum. Our aim was to synthesise existing literature to identify the barriers and enablers that influence female athlete RTS postpartum to help guide the development of evidence-based policies to support postpartum athlete RTS.DesignScoping review.Data sourcesOvid-Medline, Embase, SportDiscus and Scopus were systematically searched. Reference lists of eligible studies were also searched to identify additional studies of relevance.Eligibility criteriaOriginal, empirical, peer-reviewed, English-language studies reporting on female athletes and their RTS postpartum. Reviews, book chapters and grey literature were excluded.ResultsTwenty-two studies were included in this review. Identified barriers and enablers reflected 11 categories which occurred within and/or across three domains of the socioecological model. Five key factors were found to significantly influence female athlete RTS postpartum including (1) postpartum recovery time; (2) time to manage motherhood and sport demands; (3) sport organisation policies; (4) stereotypes; and (5) social support.ConclusionVarious barriers and enablers exist that influence successful RTS postpartum. These factors present opportunities for clinicians and sport organisations to improve their support of postpartum athletes. Paid maternity leave, offering job security, travel support for carer and child and affordable and accessible childcare are critical policy inclusions to appropriately support female athletes in their RTS postpartum.
Is alternate day dosing of oral iron an effective option for iron-deficiency anaemia?
Authors: Feather Katie , Khong Teck K 
Published: September 2023

AbstractCommentary on:Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020;99:57-63.Series Editor:Dr Teck Khong, DTB Associate Editor, Clinical Pharmacology, St George’s, University of London, UK
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
Authors: Xu Yue , Quan Zihan , Zhan Yuting , Wang Haihua , Luo Jiadi , Wang Weiyuan , Fan Songqing 
Published: September 2023

AimsEpidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases family and overexpression of EGFR has been linked to poor prognosis and cancer progression. Somatostatin receptor 2 (SSTR2) is a G-protein-coupled receptor (GPCR) with diverse biological functions in humans, and it is upregulated through the NF-KB signalling pathway in nasopharyngeal carcinomas (NPC). However, no studies have examined the EGFR and SSTR2 in NPC. This study aimed to investigate whether SSTR2 is associated with EGFR and clinicopathological features in NPC.MethodsBioinformatics analysis was performed to assess the correlation between EGFR and SSTR2 based on the GEO database. The expression of SSTR2 and EGFR was evaluated by immunohistochemistry (IHC) in 491 cases of NPC and 50 cases of non-cancerous nasopharyngeal epithelium.ResultsThe bioinformatics analysis and IHC showed a positive correlation between SSTR2 and EGFR in NPC. High expression of SSTR2 and EGFR was significantly increased in NPC patients compared with non-cancerous nasopharyngeal epithelium. High expression of SSTR2 and/or EGFR was associated with a worse outcome and a higher risk of progression. The study found that patients receiving chemoradiotherapy (CR) with high expression of SSTR2, high expression of EGFR, and high coexpression of SSTR2 and EGFR had a poorer prognosis in both progression-free survival (PFS) and overall survival (OS). Interestingly, NPC patients with high expression of SSTR2, high expression of EGFR, high coexpression of EGFR and SSTR2, and EGFR/SSTR2 anyone high expression had a better prognosis with CR combined with targeted therapy. Cox multivariate analysis identified SSTR2 and EGFR as independent poor predictors of PFS.ConclusionOur study is the first to shed light on the intricate relationship between SSTR2 and EGFR in NPC and provides new insights into the potential benefits of EGFR targeted therapy for patients with high SSTR2 expression. Additionally, SSTR2 has potential as a new biomarker for poor prognosis in NPC patients.
Comparing whole body and red muscle mitochondrial respiration in an active teleost fish, brook trout (Salvelinus fontinalis)
Authors: Durhack Travis C. , Aminot Mélanie , Treberg Jason R. , Enders Eva C. 
Published: September 2023

Understanding how metabolic costs change in relation to increasing temperature under future climate changes is important to predict how ectotherms will be affected across the globe. In fish, whole body respiration is traditionally used to estimate aerobic performance via an organism’s minimum and maximum oxygen consumption rates. However, mitochondria play a crucial role in the aerobic cascade and may be a useful surrogate of aerobic performance. To test whether whole body oxygen consumption and mitochondrial capacity are correlated, we estimated whole body metabolic and mitochondrial respiration rates (using permeabilized red muscle fibres) in brook trout ( Salvelinus fontinalis (Mitchill, 1814)) at 10, 15, and 20 °C. Standard metabolic rate increased with acclimation temperature, while maximum rates were less sensitive. All mitochondrial respiration rates increased with acclimation temperature, suggesting that red muscle mitochondrial preparations may correlate to the minimal metabolic demands in this species. When expressed as relative rates of electron flow, the red muscle fibres showed no effect of temperature on mitochondrial coupling efficiency. However, there was a pattern of declining capacity to augment respiration via complex II with increasing temperature with a concomitant increase in the capacity of the phosphorylating system relative to maximal rates of mitochondrial electron flow.
Interdisciplinary research: Motivations and challenges for researcher
careers
Authors: Vantard Marylin , Galland Claire , Knoop Martina 
Published: September 2023

Abstract
Interdisciplinarity is a fundamental asset in today’s research landscape, but its rules and habits vary from those of disciplinary approaches. This article aims to evaluate the impact of researchers’ participation in interdisciplinary projects on their scientific careers. To do so, we conducted a survey of researchers working at the Centre National de la Recherche Scientifique (CNRS), the largest public multidisciplinary research institution in France. The survey is based on a sample of 970 respondents, representative of scientists from all disciplines and involved to varying degrees in interdisciplinarity. The main results indicate that involvement in interdisciplinary projects often starts very early (PhD, postdoctoral), and that interdisciplinarity is not slowing down career development. Interdisciplinarity has, however, certain specificities, such as the longer duration of projects and the absence of adequate scientific journals. In terms of valorization of scientific results, differences in disciplinary uses are found. Assessment criteria for interdisciplinary projects or careers do not take sufficient account of these specificities; they are considered inadequate to the challenges of interaction between disciplines and should be rethought. We make four proposals, which we believe essential to better recognize interdisciplinary scientific engagement.
The quantification of open scholarship—a mapping
review
Authors: Weimer Verena , Heck Tamara , van Leeuwen Thed , Rittberger Marc 
Published: September 2023

Abstract
This mapping review addresses scientometric indicators that quantify open scholarship. The goal is to determine what open scholarship metrics are currently being applied and which are discussed (e.g., in policy papers). The paper contributes to a better understanding of how open scholarship is quantitatively recorded in research assessment and where gaps can be identified. The review is based on a search in four databases, each with 22 queries. Out of 3,385 hits, we coded 248 documents chosen according to the research questions. The review discusses the open scholarship metrics of the documents as well as the topics addressed in the publications, the disciplines the publications come from, and the journals in which they were published. The results indicate that research and teaching practices are unequally represented regarding open scholarship metrics. Open research material is a central and exhausted topic in publications. Open teaching practices, on the other hand, play a role in the discussion and strategy papers of the review, but open teaching material is not recorded using concrete scientometric indicators. Here, we see a research gap and discuss the potential for further research and investigation.
Constitutional Acquisition and Regulation of Property, Investment Treaties and Expropriation in Africa
Authors: Dagbanja Dominic Npoanlari 
Published: September 2023

Abstract
The reforms of investment treaties include the incorporation of flexibilities into standards of investment protection such as indirect expropriation to accommodate public interest regulatory autonomy. In this article, I assess the efficacy of these reforms by analysing the intersection of constitutional provisions on compulsory acquisition and regulation of property in selected African constitutions and expropriation provisions in investment treaties. I argue that indirect expropriation provisions in investment treaties are unconstitutional. I also argue that the new generation investment treaties which incorporate these exceptions do not preserve African States’ authority to acquire and regulate private property. The exceptions do not resolve the incompatibility between the constitutional authority to take and regulate property without paying compensation and African States’ investment treaty obligations on indirect expropriation. By providing for precatory and inefficacious exceptions to indirect expropriation while leaving intact substantive standards of investment protection, the reforms of investment treaties preserve an investment treaty law and arbitration regime that remains skewed towards investors and covered investments.
Fine Balance: Empire, Neoliberalism, and the Fair and Equitable Treatment Standard in International Investment Law
Authors: Das Sannoy 
Published: September 2023

Abstract
In this article, I show how the framework of empire remains central for analyzing contemporary international investment law. Moving beyond criticisms about the domination of global South polities by the West, or by a transnational capitalist class, I suggest instead that ‘empire’ can help us analyze the protocols of reasoning in investor-State arbitrations. Through a close reading of scholarship on the fair and equitable (FET) clause, and a recent arbitral award arising out an FET claim, I show that the field is characterized by an imperial mode of legal reasoning. This mode was reason was produced by a foundational distrust of postcolonial developmental States. It involves judging concrete State action against a fictional universal baseline that represents the ordoliberal utopia of an austere rule of law bound State. Crucially, in investor-State dispute settlement, this form of reasoning remains discernible even when foreign investors do not succeed.
The Intellectual Odyssey of James R. Crotty: From the War on Vietnam to a Socialist Alternative to Global Capitalism
Authors: Orhangazi Özgür , Dymski Gary 
Published: September 2023

We summarize the intellectual journey of James R. Crotty in this tribute. We discuss how Crotty’s approach to macroeconomics based on Marxian and Keynesian insights led to a series of flexible models based on realistic assumptions that help us better understand the contradictory evolution of capitalism from the 1970s to the 2010s. The basic building blocks of Crottyian macroeconomics consist of the emphasis on macro foundations, focus on the concrete capitalist processes with their endogenous, dynamic, and conflict-ridden nature, and the centrality of money, credit, and competitive dynamics of the capitalist system. We also discuss how a study of these dynamics led to his final work on “liberal socialism” as the way to end the disruptive cycles of capitalism. We argue that those aiming to construct a solid theoretical foundation to guide the understanding, transformation, and transcending of contemporary capitalist societies would find much inspiration in Crotty’s intellectual legacy. JEL Classification: E11, E12, B51
“If Keynes Were Alive Today. . .”: Reflections on Jim Crotty
Authors: Jayadev Arjun , Mason J. W. 
Published: September 2023

James Crotty, who passed away earlier this year, was one of the most important but unheralded heterodox macroeconomists of his generation. In this article, we summarize what we think were some of his signal achievements—a deep synthesis of the insights of Marx and Keynes, an appreciation of the more radical implications of the Keynesian approach, and a passion for teaching relevant ideas. JEL Classification: E12, B14
Anti-obesity Effects of Triphala at Biochemical and Molecular Level in High-Fat Diet-induced Obese Rats
Authors: Bhalerao Supriya Sudhakar , Joshi Asavari Anirudha , Khadke Suresh , Sathiyanarayan Arulmozhi 
Published: September 2023

Background The prevalence of obesity is rising worldwide. Due to the side effects associated with modern drugs, there is a need for an alternative treatment for obesity management. Triphala (TP), a polyherbal formulation from Ayurveda, is used by Ayurvedic physicians for weight loss. Purpose This study was designed to evaluate the effects of TP on obesity at the biochemical, histological, and molecular levels. Materials and Methods Male Wistar rats (125–150 g, 6–7 weeks old) were fed with a high-fat diet (HFD) for total of 48 days. From day 24 to day 48, along with HFD, rats were given an aqueous extract of TP (50, 100, and 200 mg/kg/day) or atorvastatin (1.2 mg/kg/day). Biochemical parameters were estimated in serum. Histopathology was done for the liver and adipose tissue. Levels of the genes involved in lipid metabolism were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Monoamine levels were estimated from the brain tissue. Results At the end of the study (day 48), compared to only HFD receiving group (DC), all TP-treated groups showed a significant decrease in body weight, serum glucose, total cholesterol, triglycerides, leptin, interleukin-6, C-reactive protein, malondialdehyde, and noradrenaline levels. High-density lipoprotein, adiponectin, superoxide dismutase, serotonin, and dopamine levels were found to be increased compared to DC rats. Expression of various genes involved in lipid metabolism was found to be down regulated only in TP 100 group compared with DC. Additionally, all TP groups showed a reduction in adipocyte size and restored monoamine levels. Conclusion The aqueous extract of TP had shown an anti-obesity effect as demonstrated by lowering inflammation and oxidative stress, adipocyte size, and modulation of expression of genes involved in lipid metabolism.
Attention Deficit Hyperactivity Disorder in Adults With Migraine
Authors: Gonzalez-Hernandez Ayoze , Cano-Yepes Andres , Sainz de Aja-Curbelo Victoria , Santana-Farré Ruymán , Rodríguez-Sosa Teresa , Cabrera-Naranjo Fernando 
Published: September 2023

Introduction: Several studies have shown increased occurrence of migraine in ADHD patients. However, there is less evidence on whether migraine patients also have a higher ADHD frequency. The aim of this paper is determining whether the prevalence of ADHD symptoms or impulsivity is higher in patients with episodic migraine. Methods: An observational cohort study has been conducted. Patients with episodic migraine were included. The ADHD Rating scale, the Adult ADHD Self-Report Scale, and the scale of impulsiveness of Plutchik were used. Results: The mean value of inattention, hyperactivity and impulsivity scores on the ADHD scale was 5 ± 3.8 in cases and 2.7 ± 2.2 in controls ( p < .00001), 4 ± 3.2 in cases and 2.5 ± 2.4 in controls ( p = .000621) and 2 ± 1.5 in cases and 1.1 ± 1 in controls ( p = .000407), respectively. Conclusion: Adults with migraine have a higher prevalence of ADHD symptoms. This should be considered when assessing these patients.
Safety and efficacy of remote ischemic conditioning for spontaneous intracerebral hemorrhage (SERIC-ICH): A multicenter, randomized, parallel-controlled clinical trial study design and protocol
Authors: Guo Zhen-Ni , Qu Yang , Abuduxukuer Reziya , Zhang Peng , Wang Lijuan , Liu Ying , Teng Rui-Hong , Gao Jian-Hua , Jin Feng , Wang Hai-Feng , Cao Yu , Xue Yong-Quan , Zhao Jun-Feng , Selim Magdy H , Nguyen Thanh N , Yang Yi 
Published: September 2023

Background: Previous studies have revealed that remote ischemic conditioning (RIC) may have a neuroprotective function. However, the potential benefit of RIC for patients with ICH remain unclear. Objective: The primary aim of this study is to assess the safety and efficacy of RIC for patients with ICH. Methods: The Safety and Efficacy of RIC for Spontaneous ICH (SERIC-ICH) is an ongoing prospective, randomized, multicenter, parallel-controlled, and blinded-endpoint clinical trial. The study will enroll an estimated 2000 patients aged ⩾18 years within 24 h after ICH onset, with National Institutes of Health Stroke Scale ⩾6 and Glasgow Coma Scale ⩾8 upon presentation. The patients will be randomly assigned to the RIC or control groups (1:1) and will be treated with cuffs inflated to a pressure of 200 or 60 mmHg, respectively, twice daily for 7 days. Each RIC treatment will consist of four cycles of arm ischemia for 5 min, followed by reperfusion for another 5 min, for a total procedure time of 35 min. The primary efficacy outcome measure is the proportion of patients with good functional outcomes (modified Rankin scale 0–2) at 180 days. The safety outcome measures will include all adverse events and severe adverse events occurring in the course of the study. Discussion: RIC is an inexpensive intervention and might be a strategy to improve outcomes in patients with ICH. The SERIC-ICH trial will investigate whether RIC treatment can be applied as an adjuvant treatment in the acute phase of ICH and identify safety issues.
Risk factors in underweight older children with sickle cell anemia: a comparison of low- to high-income countries
Authors: Klein Lauren Jane , Abdullahi Shehu Umar , Gambo Safiya , Stallings Virginia A. , Acra Sari , Rodeghier Mark , DeBaun Michael R. 
Published: September 2023

Abstract
Previously, we demonstrated that older children with sickle cell anemia (SCA) living in Nigeria are at increased risk of death if they are underweight (weight-for-age z score &lt; −1). We now conducted a cross-sectional study in low- and high-income settings to determine the risk factors for being underweight a in children aged 5 to 12 years with SCA. The children from low- and high-income settings were eligible participants for the Primary Prevention of Stroke in Children with Sickle Cell Disease in Nigeria (SPRING; N = 928) and the Silent Cerebral Infarct (SIT, North America/Europe; N = 1093) trials, respectively. The median age in the SPRING and SIT cohorts was 8.1 and 8.5 years, respectively (P &lt; .001). A total of 87.9% (n = 816) of participants in the SPRING trial (low-income) met the study criteria for being underweight (weight-for-age z score &lt; −1), and 22.7% (n = 211) for severely underweight (weight-for-age z score &lt; −3), significantly higher than the SIT (high-income) cohort at 25.7% underweight (n = 281) and 0.7% severely underweight (n = 8; P &lt; .001 for both comparisons). In the combined cohort, older age (odds ratio [OR], 1.24; P &lt; .001) and lower hemoglobin level (OR, 0.67; P &lt; .001) were associated with being underweight. Age and hemoglobin level remained statistically significant in separate models for the SPRING and SIT cohorts. Older age and lower hemoglobin levels in children aged 5 to 12 years with SCA are associated with being underweight in low- and high-income settings.
Application of R2-ISS risk stratification to patients with multiple myeloma treated with autologous stem cell transplants at UAMS
Authors: Guo Wancheng , Zhan Anne , Mery David E. , Munshi Manit N. , Makhoul Oussama , Baily Clyde , Zangari Maurizio , Tricot Guido , Peng Hongling , Shaughnessy John D. 
Published: September 2023

Abstract
The Second Revision of the International Staging System (R2-ISS) was published in 2022 and has been validated in several cohorts of patients with multiple myeloma (MM). In this study, we investigated a total of 860 patients with MM who received an upfront autologous stem cell transplantation between 2001 and 2021. The median age of the patients was 60 years, with a median overall survival (OS) of 123 months and median progression-free survival (PFS) of 70 months. We collected the variables included in the ISS, R-ISS, and R2-ISS systems as well as additional standard variables. Our analyses demonstrated that all 3 ISS series systems (ISS, R-ISS, and R2-ISS) exhibited robust discrimination in terms of both OS and PFS among our study cohort. The ISS system effectively stratified patients into 3 risk groups, whereas the R-ISS system accurately identified patients at extremely high or low risk. The R2-ISS system further refined risk stratification by dividing patients into 4 more balanced risk groups. Furthermore, we specifically focused on identifying variables that distinguished patients with OS &lt; 3 years and OS &gt; 10 years within the low-risk R2-ISS stages (I and II) and high-risk R2-ISS stages (III and IV). Our findings revealed that age, hemoglobin, and 1p deletion significantly influenced the classification of patients in the low-risk R2-ISS stage. Additionally, serum light chain, platelet count, age, and the presence of the t(14;16) translocation were found to affect high-risk classification.