bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic synthesis of (Gd1−xLax)2O2SO4:Tb3+ and (Gd1−xLax)2O2S:Tb3+ nanophosphors for remarkably enhanced luminescence
Authors: Song Zhenqi , Li Fan , Feng Sihan , Pan Zhiyuan , Zhu Qi , Sun Xudong , Li Ji‐Guang 
Published: August 2023

AbstractCoprecipitation with rare‐earth nitrate, ammonium sulfate, and ammonium hydroxide produced hydroxide‐type amorphous precursors incorporating sulfate and carbonate anions, from which [(Gd1−xLax)0.99Tb0.01]2O2SO4 and [(Gd1−xLax)0.99Tb0.01]2O2S (x = 0, 0.15, 0.3, 0.5, 0.65, 0.8, and 1) were obtained as two series of nanophosphors by calcination at 950°C in air and hydrogen, respectively. The detailed characterization by X‐ray diffractometer, scanning electron microscopy/transmission electron microscopy, Brunauer–Emmett–Teller, and particle sizing confirmed that solid solutions were directly formed and that the products have small crystallite size, unimodal size distribution, and high specific surface area, revealing the advantages of the synthesis method. Photoluminescence study revealed that La3+ admixture may significantly improve the 545 nm main emission of Tb3+ for both the phosphor series. Furthermore, the 545 nm main emission of [(Gd1−xLax)0.99Tb0.01]2O2SO4 was identified to have an excellent thermal stability, which retained over 90% of its room‐temperature intensity at 150°C (no quenching for Gd2O2SO4:Tb3+). The two series of phosphors were comparatively studied for their excitation and luminescence performances, as a function of temperature and La3+ content, and the results were rationalized by considering bandgap, crystal structure, UV absorption, and the character of chemical bonds.
CircLDLRAD3 inhibits Oral squamous cell carcinoma progression by regulating miR‐558/Smad4/TGF‐β
Authors: Zhang Xue , Guo Guang‐Yu , Liu Ru‐Yue , Wu Ting , Wang Zhen‐Hua , Zhang Zhong‐Ti 
Published: August 2023

AbstractOral squamous cell carcinoma (OSCC) is a malignant neoplasm with high mortality and morbidity. The role of circRNA and its molecular mechanism in OSCC remains largely unknown. The study aims to explore the role of a novel circular RNA (circLDLRAD3) in OSCC and its underlying mechanism. PCR and fluorescence in situ hybridization were used to explore the expression features of circLDLRAD3 in OSCC. The effects of circLDLRAD3 on the behaviour of OSCC were investigated using CCK‐8, colony formation assay, transwell and animal experiments. Bioinformatics analysis along with dual luciferase reporter assay and RIP assay were used to reveal the interaction between circLDLRAD3, miR‐558 and Smad4. It was revealed that circLDLRAD3 exhibited low expression status in OSCC. CircLDLRAD3 inhibits proliferation, migration, and invasion of OSCC cells both in vitro and in vivo. Mechanistically, circLDLRAD3 could bind with miR‐558 to positively regulate its target gene Smad4 expression. Rescue experiments further confirmed both miR‐558 overexpression and Smad4 knockdown could reverse the influence of circLDLRAD3 on OSCC phenotypes. Moreover, circLDLRAD3 regulate the TGF‐β signalling pathways to influence EMT through miR‐558/Smad4 axis. Our study found that circLDLRAD3 is downregulated in OSCC and verified its tumour suppressor function and mechanism in OSCC through sponging miR‐558 to regulate miR‐558/Smad4/TGF‐β axis. The characterization of such regulating network uncovers an important mechanism underlying OSCC progression, which could provide promising targets targeted therapy strategies for OSCC in the future.
Spatiotemporal variability in diet composition of Greenland halibut (Reinhardtius hippoglossoides) from the eastern Canadian Arctic
Authors: Tremblay‐Gagnon Félix , Brown‐Vuillemin Sarah , Skanes Katherine , Polaczek Hannah , Walkusz Wojciech , Robert Dominique , Deslauriers David 
Published: August 2023

AbstractGreenland halibut (Reinhardtius hippoglossoides) sustain one of the most lucrative fisheries in the eastern Canadian Arctic and Labrador Sea. This species also plays an important role in food web connectivity and benthic–pelagic coupling. Despite the relatively rich knowledge of this species, R. hippoglossoides ecology in these specific areas remains poorly understood. The main aim of this study was to characterize the diet of this deepwater fish in the Labrador Sea and Davis and Hudson Straits and characterize the predator–prey relationship with northern shrimp (Pandalus borealis), another commercially important species in the region. Stomach contents analyses were conducted on 1199 fish captured from 2018 to 2020. Small specimens (<20 cm) fed on invertebrates, whereas larger individuals (>60 cm) fed primarily on fish, indicative of size‐related changes in diet composition. The relative abundance of Pandalus shrimp species in the environment was reflected in the diet. Location appeared to be the most influential variable on feeding patterns. Distinct oceanographic conditions among areas, resulting in differences in prey availability, could explain these results. Arctic cod (Boreogadus saida) and redfish (Sebastes sp.) were selected in locations where fish prey were the most abundant. These results shed light on the opportunistic nature of R. hippoglossoides and its preference for fish at large size. With the rapidly changing oceanographic conditions of Arctic waters, a distributional change in the biomass of shrimp is expected. Results suggest that an increase in abundance of predatory groundfish species in the system (e.g., Sebastes sp.) could lead to acute predation on shrimp and competition with R. hippoglossoides. By revealing key trophic links within the demersal ecosystem, this work provides valuable information on the development of ecosystem approaches to fisheries management for the region.
The transcription factor NAC102 confers cadmium tolerance by regulating WAKL11 expression and cell wall pectin metabolism in Arabidopsis
Authors: Han Guang Hao , Huang Ru Nan , Hong Li Hong , Xu Jia Xi , Hong Yi Guo , Wu Yu Huan , Chen Wei Wei 
Published: August 2023

ABSTRACTCadmium (Cd) toxicity severely limits plant growth and development. Moreover, Cd accumulation in vegetables, fruits, and food crops poses health risks to animals and humans. Although the root cell wall has been implicated in Cd stress in plants, whether Cd binding by cell wall polysaccharides contributes to tolerance remains controversial, and the mechanism underlying transcriptional regulation of cell wall polysaccharide biosynthesis in response to Cd stress is unknown. Here, we functionally characterized an Arabidopsis thaliana NAC‐type transcription factor, NAC102, revealing its role in Cd stress responses. Cd stress rapidly induced accumulation of NAC102.1, the major transcript encoding functional NAC102, especially in the root apex. Compared to wild type (WT) plants, a nac102 mutant exhibited enhanced Cd sensitivity, whereas NAC102.1‐overexpressing plants displayed the opposite phenotype. Furthermore, NAC102 localizes to the nucleus, binds directly to the promoter of WALL‐ASSOCIATED KINASE‐LIKE PROTEIN11 (WAKL11), and induces transcription, thereby facilitating pectin degradation and decreasing Cd binding by pectin. Moreover, WAKL11 overexpression restored Cd tolerance in nac102 mutants to the WT levels, which was correlated with a lower pectin content and lower levels of pectin‐bound Cd. Taken together, our work shows that the NAC102‐WAKL11 module regulates cell wall pectin metabolism and Cd binding, thus conferring Cd tolerance in Arabidopsis.
Methyl donor supplementation reduces phospho‐Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy
Authors: van Hummel Annika , Taleski Goce , Sontag Jean‐Marie , Feiten Astrid Feentje , Ke Yazi D. , Ittner Lars M. , Sontag Estelle 
Published: August 2023

AbstractBackgroundReduced folate status and elevated levels of circulating homocysteine are modifiable risk factors for cognitive decline and dementia. Disturbances in one‐carbon metabolism are associated with the pathological accumulation of phosphorylated tau, a hallmark feature of prevalent dementia, including Alzheimer's disease and subgroups of frontotemporal dementia.MethodsHere, using transgenic TAU58/2 mouse models of human tauopathy, we tested whether dietary supplementation with L‐methylfolate (the active folate form), choline and betaine can reduce tau phosphorylation and associated behavioural phenotypes.ResultsTAU58/2 mice fed with the methyl donor‐enriched diet showed reduced phosphorylation of tau at the pathological S202 (CP13) and S396/S404 (PHF‐1) epitopes and alleviation of associated motor and learning deficits. Compared with mice on the control diet, the decrease in cortical phosphorylated tau levels in mice fed with the methyl donor‐enriched diet was associated with enhanced methylation of protein phosphatase 2A, the major brain tau Ser/Thr phosphatase. It also correlated with a reduction in protein levels of Fyn, a tau tyrosine kinase that plays a central role in mediating pathological tau‐induced neurodegeneration. Conversely, Fyn expression levels were increased in mice with deficiencies in folate metabolism.ConclusionsOur findings provide the first experimental evidence that boosting one‐carbon metabolism with L‐methylfolate, choline and betaine can mitigate key pathological, learning and motor deficits in a tauopathy mouse model. They give support to using a combination of methyl donors as a preventive or disease‐modifying strategy for tauopathies.
Computing parameter identifiability and other structural properties for natural resource models
Authors: Stigter J. D. 
Published: August 2023

AbstractFor dynamic natural resource models a few fundamental questions are often omitted in practice such as (i) “Is it possible to calibrate the model?” and (ii) “Can we reconstruct all unknown dynamic state variables given a certain data record?” Other related questions are (iii) “Does the system allow the state variables to be controlled (or managed) to desired optimal values (e.g., in case of maximum sustainable yield)?” In this paper we highlight and discuss a software tool (the StrucID App) that allows a rapid evaluation of these fundamental and structural model properties that are important to study before a calibration and subsequent simulation of the model.
Determinants of remittance outflows: The case of Saudi Arabia
Authors: Javid Muhammad , Hasanov Fakhri J. 
Published: August 2023

AbstractThe Saudi Arabian economy heavily uses foreign labour and hence, ranks among the top countries not only in the Gulf Cooperation Council region, but also globally in terms of remittance outflows. This study develops a theoretical model to investigate the determinants of remittance outflows from Saudi Arabia. The cointegration and equilibrium correction methods, and adjustments for small sample bias, are applied to the data for 1970‐2021 using the theoretical model developed. In the long run, keeping other factors unchanged, Saudi Arabia's gross domestic and non‐Saudi employment have positive and statistically significant impacts on the remittance outflows, while the impacts of the price level and expatriate levy are negative and statically significant. This study's findings may be useful for macroeconomic policymaking, as the remittance outflows have numerous implications for the development of the Saudi economy. Particularly, remittances are a primary channel for leaking money from Saudi Arabia, reducing the economic growth effects of fiscal spending multipliers.
Esprit de Corpsand thinking on (and with) your feet: Standard, enactive, and poststructuralist aspects of relational autonomy and collective intentionality in team sports
Authors: Protevi John 
Published: August 2023

AbstractTo concretize my discussion of relational autonomy and collective intentionality, I present a case study in which we can see several themes in that scholarly literature exemplified in a real‐life event. The event in question is the Megan Rapinoe‐Abby Wambach goal in the quarterfinals of the Women's World Cup of 2011, one of the greatest in all World Cup history (A video clip of the goal can be found at:https://www.youtube.com/watch?v=0B4q6di‐3fg.). In the case study, I concentrate on the ontological status of two key aspects of soccer, the linking of teammates by a pass, and the emergence of the team from the interactions of players. I use concepts drawn from poststructuralism, phenomenology, and enactivist approaches to embodied cognition.
Erythematous reactions to two ultraviolet excimer therapy devices with different irradiance levels: Reconsidering the reciprocity law
Authors: Togawa Yaei , Kawashima Shusuke , Nagai Kazue , Kawasaki Yohei , Matsue Hiroyuki 
Published: August 2023

AbstractBackgroundFew studies have examined the effectiveness of the reciprocity law in ultraviolet excimer therapy. This study aimed to examine the difference in erythematous reaction in human skin when the irradiance of ultraviolet excimer treatment devices differed while the irradiation dose was constant.Materials and methodsThis study, conducted at the Department of Dermatology, Chiba University, included 15 healthy adults aged 20–65 years (mean age, 46.3 years; seven men). Using ultraviolet excimer treatment devices with different irradiances (50 or 150 mW/cm2), the upper abdomen of each participant was irradiated with ultraviolet light at set irradiation doses (80, 100, 120, 140, 160, 180, and 200 mJ/cm2). The erythema index of each irradiated site was measured using a melanin‐ and erythema‐measuring device, and the difference in erythema index before and 24 h after irradiation was the primary endpoint.ResultsThe change in erythema index was significantly higher for an irradiance of 150 mW/cm2. Significant differences (p < 0.05) were observed between these irradiance levels at irradiation doses of 100‒200 mJ/cm2.ConclusionsEven for the same irradiation dose, stronger erythematous reactions occurred at higher irradiances in ultraviolet excimer treatment. This suggests that the reciprocity law may not always hold true in excimer therapy.
MED8 regulates floral transition in Arabidopsis by interacting with FPA
Authors: Yuan Chen , Hu Yikai , Liu Qinggang , Xu Jingya , Zhou Wei , Yu Hao , Shen Lisha , Qin Cheng 
Published: August 2023

SUMMARYSuccess in plant reproduction is highly dependent on the correct timing of the floral transition, which is tightly regulated by the flowering pathways. In the model plant Arabidopsis thaliana, the central flowering repressor FLOWERING LOCUS C (FLC) is precisely regulated by multiple flowering time regulators in the vernalization pathway and autonomous pathway, including FPA. Here we report that Arabidopsis MEDIATOR SUBUNIT 8 (MED8) promotes floral transition in Arabidopsis by recruiting FPA to the FLC locus to repress FLC expression. Loss of MED8 function leads to a significant late‐flowering phenotype due to increased FLC expression. We further show that MED8 directly interacts with FPA in the nucleus and recruits FPA to the FLC locus. Moreover, MED8 is indispensable for FPA's function in controlling flowering time and regulating FLC expression. Our study thus reveals a flowering mechanism by which the Mediator subunit MED8 represses FLC expression by facilitating the binding of FPA to the FLC locus to ensure appropriate timing of flowering for reproductive success.
A test of the interaction between central and peripheral respiratory chemoreflexes in humans
Authors: Guluzade Nasimi A. , Huggard Joshua D. , Duffin James , Keir Daniel A. 
Published: August 2023

AbstractHow central and peripheral chemoreceptor drives to breathe interact in humans remains contentious. We measured the peripheral chemoreflex sensitivity to hypoxia (PChS) at various isocapnic CO2 tensions () to determine the form of the relationship between PChS and central . Twenty participants (10F) completed three repetitions of modified rebreathing tests with end‐tidal () clamped at 150, 70, 60 and 45 mmHg. End‐tidal (), , ventilation (E) and calculated oxygen saturation (SCO2) were measured breath‐by‐breath by gas‐analyser and pneumotach. The E– relationship of repeat‐trials were linear‐interpolated, combined, averaged into 1 mmHg bins, and fitted with a double‐linear function (ES, L min−1mmHg−1). PChS was computed at intervals of 1 mmHg of as follows: the difference in E between the three hypoxic profiles and the hyperoxic profile (∆E) was calculated; three ∆E values were plotted against corresponding SCO2; and linear regression determined PChS (Lmin−1mmHg−1%SCO2−1). These processing steps were repeated at each to produce the PChS vs. isocapnic relationship. These were fitted with linear and polynomial functions, and Akaike information criterion identified the best‐fit model. One‐way repeated measures analysis of variance assessed between‐condition differences. ES increased (P < 0.0001) with isoxic from 3.7 ± 1.5 L min−1mmHg−1 at 150 mmHg to 4.4 ± 1.8, 5.0 ± 1.6 and 6.0 ± 2.2 Lmin−1mmHg−1 at 70, 60 and 45 mmHg, respectively. Mean SCO2 fell progressively (99.3 ± 0%, 93.7 ± 0.1%, 90.4 ± 0.1% and 80.5 ± 0.1%; P < 0.0001). In all individuals, PChS increased with , and this relationship was best described by a linear model in 75%. Despite increasing central chemoreflex activation, PChS increased linearly with indicative of an additive central–peripheral chemoreflex response.
imageKey points
How central and peripheral chemoreceptor drives to breathe interact in humans remains contentious.
We measured peripheral chemoreflex sensitivity to hypoxia (PChS) at various isocapnic carbon dioxide tensions () to determine the form of the relationship between PChS and central .
Participants performed three repetitions of modified rebreathing with end‐tidal fixed at 150, 70, 60 and 45 mmHg. PChS was computed at intervals of 1 mmHg of end‐tidal () as follows: the difference in E between the three hypoxic profiles and the hyperoxic profile (∆E) was calculated; three ∆E values were plotted against corresponding calculated oxygen saturation (SCO2); and linear regression determined PChS (Lmin−1mmHg−1%SCO2−1).
In all individuals, PChS increased with , and this relationship was best described by a linear (rather than polynomial) model in 15 of 20.
Most participants did not exhibit a hypo‐ or hyper‐additive effect of central chemoreceptors on the peripheral chemoreflex indicating that the interaction was additive.
Heat Transfer and Pressure Loss Correlations for Leading Edge, Jet Impingement Using Racetrack-Shaped Jets With Filleted Edges
Authors: Kulkarni Ritwik V. , Wright Lesley M. 
Published: August 2023

Abstract
This paper presents an experimental investigation of heat transfer and pressure loss for leading-edge jet impingement using racetrack-shaped jets. The majority of literature for gas turbine cooling applications considers jet impingement using square or sharp-edged orifices. However, the edge of the jet orifices generally has some degree of filleting (or rounding) along the edges, due to casting the airfoils or material wear due to long-term operation. Engineers need data under realistic engine configurations to improve the utilization of coolant while adequately protecting the airfoil. The current experimental study is a parametric investigation of heat transfer and pressure loss for leading-edge jet impingement, where the effects of jet Reynolds number (Re = 10,000–100,000), jet–to–jet spacing (s/d = 2–8), jet–to–target surface spacing (z/d = 2–4), surface curvature (D/d = 2.67–5.33), and jet fillet–to–jet plate thickness (r/l = 0.16–0.5) are each considered. The edge rounding at both the inlet and outlet of the jet plate yields reduced heat transfer compared to the square-edged jets. However, the fillets significantly improve the discharge coefficients associated with the racetrack-shaped orifices. With the extensive testing completed in this study, design correlations have been developed to predict the surface Nusselt number and discharge coefficients, with 10% and 19% deviation from experimental results, respectively. Engine designers can predict the level of heat transfer and pressure loss for leading-edge jet impingement using these correlations.
Visual Observation and Analytical Study of the Heat Load Sharing Mode in Multi-Evaporator Loop Heat Pipe
Authors: Kizawa Masafumi , Watanabe Noriyuki , Ueno Ai , Chang Xinyu , Nagano Hosei 
Published: August 2023

Abstract
In this paper, the operating characteristics of the heat load sharing mode of multiple-evaporator loop heat pipe (MLHP) were elucidated based on a visual observation test. The heat load sharing mode is a function of MLHPs that can share the heat between the evaporators through the vapor without electronic power for the heat storage utilization. A visualized MLHP with two evaporators and one condenser was designed and fabricated. To simulate the heat load sharing mode in the MLHP, one evaporator was heated in the range of 40–280 W and the other evaporator was cooled using a water jacket in the range of 10–80 °C. Under the heat load sharing mode, the flow behaviors in the evaporator cores and the compensation chambers were visually observed using borescope cameras, respectively. Moreover, two operating modes (defined as Mode A and Mode B) that affect the maximum heat sharing capability were identified. In Mode A, the heat sharing rate was proportional to the heat dissipation at the cooled side of evaporator, where the capillary force at the wick significantly affected the operation mode. By contrast, in Mode B, the heat sharing rate reached the upper limit and then was constant regardless of the heat dissipation. Furthermore, the proposed concept model can predict the transition of the operation mode from Mode A to Mode B.
Thermomechanical Performance Assessment of U-Mo Monolithic Fuel Plates With Zircaloy Cladding
Authors: Ozaltun Hakan , Cole James I. , Rabin Barry H. 
Published: August 2023

Abstract
Performance of two distinct fuel systems, U-7Mo fuel in Zircaloy (Zry-4) cladding and U-10Mo fuel in aluminum (Al6061-O) cladding was studied. First, a mini plate with Zry-4 cladding from a previous irradiation experiment was evaluated via finite element analysis (FEA). By using the same plate geometry and irradiation conditions, another plate consisting of U-10Mo fuel and Al6061-O cladding was simulated. The results were then comparatively evaluated to explore the feasibility of employing Zry-4 as an alternative cladding. Simulations indicated the Zircaloy cladding plate would operate roughly 50 °C hotter as compared with the Al alloy cladding plate. Larger deformations in the thickness direction for the plate with Zry cladding were noted. It was observed that the postfabrication stresses in the fuel would be relieved quickly in the reactor, regardless of cladding type. Although the fuel stresses would still develop at reactor shutdown, the fuel would be stress-free during the entire irradiation period for both cladding types. At shutdown, the plate with Zry cladding would have higher stresses due to higher operating temperatures. Similarly, the stresses after shutdown are higher in the foil core for the plates with Zry cladding. The Al cladding plate would have higher plastic strains as compared with the Zry cladding plate. The Zry cladding plate is significantly stiffer, causing higher stresses in the fuel zone and at the interface. Overall, employing Zry as an alternate cladding is not expected to produce a more favorable thermomechanical performance as compared to the performance of an Al alloy cladding plate.