bluuebunny/crossref_metadata_2025_split huggingface dataset:
Up IGF-I via High-toughness Adaptive Hydrogels for Remodeling Growth Plate of Children
Authors: Zhang Zhiqiang , Li Haodong , Qian Manning , Zheng Yiming , Bao Luhan , Cui Wenguo , Wang Dahui 
Published: January 2025

Abstract
The growth plate is crucial for skeletal growth in children, but research on repairing growth plate damage and restoring growth is limited. Here, a high-toughness adaptive dual-crosslinked hydrogel designed to mimic the growth plate's structure, supporting regeneration and bone growth. Composed of aldehyde-modified bacterial cellulose (DBNC), methacrylated gelatin (GelMA), and sodium alginate (Alg), the hydrogel is engineered through ionic bonding and Schiff base reactions, creating a macroporous structure. This structure can transform into a denser form by binding with calcium ions. In vitro, the loose macroporous structure of the hydrogels can promote chondrogenic differentiation, and when it forms a dense structure by binding with calcium ions, it also can activate relevant chondrogenic signaling pathways under the influence of IGF-1, further inhibiting osteogenesis. In vivo experiments in a rat model of growth plate injury demonstrated that the hydrogel promoted growth plate cartilage regeneration and minimized bone bridge formation by creating a hypoxic microenvironment that activates IGF-1-related pathways. This environment encourages chondrogenic differentiation while preventing the undesired formation of bone tissue within the growth plate area. Overall, the dual-crosslinked hydrogel not only mimics the growth plate's structure but also facilitates localized IGF-1 expression, effectively reshaping the growth plate's function. This approach represents a promising therapeutic strategy for treating growth plate injuries, potentially addressing challenges associated with skeletal growth restoration in pediatric patients.
Build or Buy? Human Capital and Corporate Diversification
Authors: Beaumont Paul , Hebert Camille , Lyonnet Victor 
Published: January 2025

Abstract
Firms enter new sectors by either building on their resources or buying existing companies. Using French administrative data, we propose a measure of human capital distance between a firm and a sector of entry. Using a shift-share instrument, we show that firms build in close sectors and buy in distant sectors in terms of human capital distance. Firms build by hiring new workers, which becomes increasingly costly in distant sectors as it requires not only hiring more workers but also having more organizational capital to integrate these workers. Hence, firms buy in distant sectors to acquire already operational human capital.
Double-layer sign of the anterior lens capsule during cataract surgery: A case report
Authors: Liu Ruoxi , Shao Hongzhan , Xu Xiaoli , Huang Shanshan 
Published: January 2025

Rationale:
The double-layer sign of the anterior lens capsule during continuous curvilinear capsulorrhexis (CCC) in cataract surgery is a rare phenomenon. This case report highlights the occurrence of this sign and provides a practical technique for managing it.

Patient concerns:
A 55-year-old Chinese woman presented with blurred vision in her left eye. She had a history of nuclear sclerotic cataracts, but no abnormalities of the anterior capsule were noted in her preoperative evaluation.

Diagnoses:
Nuclear sclerotic cataract in the left eye with no preoperative abnormalities of the anterior lens capsule.

Interventions:
During CCC, a double-layer sign of the anterior lens capsule was identified. The surgeon successfully managed the double-layer sign by simultaneously grasping both layers with capsulorhexis forceps to complete CCC without complications.

Outcomes:
Postoperatively, the patient achieved 20/20 vision in the treated eye, and no complications were observed.

Lessons:
The double-layer sign of the anterior lens capsule is a rare finding during cataract surgery. Although its exact cause remains unclear, the technique described offers a practical approach to manage this intraoperative challenge effectively.
A bibliometric analysis of the development trend of Tuina research: Based on the Web of Science (WOS) platform
Authors: Gao Lin , Chen Suyu , Gao Tianlei , Yang Liuying , Tai Xiantao 
Published: January 2025

Background:
Tuina has been proven to significantly relieve symptoms, demonstrating its clinical value. With the growth of related research, a comprehensive review is urgently needed to promote its development. This study aims to clarify the collaboration and current research status in the field of Tuina research using bibliometric analysis, and to discuss future directions.

Methods:
On February 4, 2023, the Web of Science Core Collection (WoSCC) database was searched using the keywords “tuina,” “tui-na,” “tui na,” and “Chinese massage” to collect literature related to Tuina from its inception until December 31, 2022. The collected literature included all types of research articles and reviews. VOSviewer, CiteSpace, Pajek, and Scimago Graphica were utilized to perform a visual analysis of annual publication volume, as well as publication volume and collaboration networks of different countries, institutions, and authors, along with journal publication volume and keyword network analysis.

Results:
A total of 761 publications were included in the analysis, with the total number of papers showed an increasing trend over time. The countries and institutions with the most publications were China and Shanghai University of Traditional Chinese Medicine, respectively. The authors who contributed the most were Min Fang, Qingguang Zhu, Zhiwei Wu, Lingjun Kong and Yufeng Wang. The most widely published journal in the field was the Journal of Acupuncture and Tuina Science. The clinical efficacy evaluation of Tuina therapy for musculoskeletal and spinal diseases, apoplexy sequelae, chronic diseases, and pediatric diseases were research hotspots and developing trends in this field.

Conclusion:
The research on Tuina has been increasing year by year. Currently, the focus of Tuina research lies in clinical studies, including the treatment of skeletal muscle and spinal diseases, stroke sequelae, chronic diseases, and pediatric illnesses, with pediatric Tuina emerging as a hot topic of research. Basic research in this field is relatively scarce, and the mechanisms of action of this therapy have not yet been fully elucidated. Future efforts in this area should aim to strengthen basic research and promote cooperation among international institutions.
Comparison of TPF and PF induction chemotherapy combined with cisplatin concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: A systematic review and meta-analysis
Authors: Li Haiwen , Wu Qibiao , Luo Haiqing , Wu Jiayuan , Su Wenmei , Yu Lili 
Published: January 2025

Background:
The standard of care for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) is induction chemotherapy (ICT) followed by concurrent chemoradiation (CCRT). However, the ideal ICT regimen for LA-NPC remains unclear. We conducted a meta-analysis to evaluate the survival outcomes, responses, and incidences of toxicities between taxane, cisplatin and fluorouracil (TPF) and cisplatin and fluorouracil (PF) ICT regimens plus CCRT in LA-NPC.

Methods:
A systematic review and meta-analysis of the literature was conducted to compare the efficacy and safety of TPF versus PF followed by CCRT with cisplatin every 3 weeks or weekly cisplatin and intensity-modulated radiotherapy in LA-NPC.

Results:
Three studies with 2482 patients met the inclusion criteria. ICT with the TPF regimen plus CCRT resulted in a significantly improved progression-free survival (hazard ratios [HR] 0.84 [95% CI 0.73–0.96], P = .01), overall survival (HR 0.83 [95% CI 0.71–0.97], P = .02), and 3-year locoregional recurrence-free survival (risk ratios [RR] 1.03 [95% CI 1.01–1.06], P = .009) compared with the PF regimen plus CCRT in LA-NPC. However, distant metastasis-free survival was not statistically significant (P = .07). The incidence of grade 3 or 4 neutropenia (RR 2.08 [95% CI 1.84–2.36]) and diarrhea (RR 1.94 [95% CI 1.07–3.52]) during ICT was higher in the TPF group than in the PF group.

Conclusions:
In terms of progression-free survival, overall survival, locoregional recurrence-free survival, in the era of intensity-modulated radiotherapy, the TPF plus CCRT with cisplatin is superior to PF plus CCRT with cisplatin in LA-NPC. Thus, the TPF plus CCRT regimen appears to be a reasonable treatment option, and further confirmation by prospective studies is needed.
An iliac arteriovenous fistula associated with leg swelling 2 years after the removal of a hemodialysis catheter: A case report
Authors: Du Tao , Zheng Xing 
Published: January 2025

Rationale:
Temporary central venous catheters are commonly used for patients who require emergency hemodialysis. In rare instances, this procedure can result in a very serious complication known as arteriovenous fistula (AVF). Although some cases of femoral arteriovenous fistula have been reported previously in the literature; however, the incidence of iliac AVF precipitated by a hemodialysis catheter is exceedingly uncommon. The purpose of this study is to report a case in which a hemodialysis catheter caused a femoral arteriovenous fistula and to describe the successful treatment, thereby providing a reference for the diagnosis and treatment of such conditions in the future.

Patient concerns:
Herein, we report the case of a patient with diabetes and end-stage kidney disease (ESKD) who presented with an iliac arteriovenous fistula as a complication of hemodialysis catheter insertion into the right femoral vein. Two years after hemodialysis catheter removal, the patient was admitted to our institution with swelling of the right lower limb and calf pain.

Diagnosis:
The patient was subsequently diagnosed with an iliac arteriovenous fistula by computed tomography angiography and angiography.

Interventions:
The patient was transferred to the Vascular Surgery Department for surgical treatment.

Outcomes:
The patient’s leg swelling improved after surgery. After 1 year of follow-up, there was no occurrence of swelling in the patient’s right leg.

Lessons:
If the patient has a history of femoral venous catheter placement and develops limb swelling, in addition to considering the presence of a femoral arteriovenous fistula, it is important to consider the possibility of an iliac AVF. Iliac AVF are rare disorders. The primary goal for treatment of IAVF is to relieve associated symptoms. Based on the results of this study, the endovascular approach is safe and effective for the treatment of iliac AVF. Iliac AVFs are rare disorders. The primary goal of treatment for iliac AVFs is to relieve associated symptoms. Based on the results of this study, the endovascular approach is safe and effective in the treatment of iliac AVFs.
Surgical treatment of cerebellar pontine angle lipoma combined with trigeminal neuralgia: A case report
Authors: Yin Yu-Ting , Gui Chao 
Published: January 2025

Rationale:
Cerebellar pontine angle lipomas with trigeminal neuralgia are rare. The treatment choice is influenced by whether the pain is caused by the lipoma or the compression of blood vessels. Herein, we aimed to report a case of the disease and provide a reference for its treatment.

Patient concerns:
The patient was a 54-year-old female who presented with a 20-year history of left-sided facial pain. Her pain had gradually worsened over time and oral medications became progressively less effective.

Diagnoses:
Brain magnetic resonance imaging detected a left cerebellar horn lesion, which was deemed a lipoma. Three-dimensional time-of-flight magnetic resonance angiography revealed a superior cerebellar artery adjacent to the trigeminal nerve root. Trigeminal nerve roots may have been compressed by lipomas and blood vessels.

Interventions:
The patient underwent a microvascular decompression of the trigeminal nerve. Part of the lipoma was removed, and the trigeminal nerve was isolated from the blood vessels and tumor.

Outcomes:
Postoperative pathology confirmed a lipoma. Neuralgia was completely relieved postoperatively, and no new neurological disorder was detected during the 6-month follow-up.

Lessons:
Surgery is recommended for patients with cerebellar pontine angle lipomas combined with trigeminal neuralgia when conservative treatment fails. Detailed preoperative imaging is crucial to identify lipomas and trigeminal root compression by the responsible artery. Complete decompression of the trigeminal nerve root is necessary for complete pain relief.
Exclusive liposuction with glandular tissue redistribution for severe gynecomastia: A case report
Authors: Yan Bingwen , Hong Xuezhe , Hao Dongyue , Zhang Juan , Pei Jiaomiao , Sun Liming , Cang Zhengqiang , Chen Yongjun , Ma Ying , Song Baoqiang , Liu Chaohua 
Published: January 2025

Rationale:
Gynecomastia, characterized by abnormal enlargement of male breast tissue, can lead to significant psychological distress, particularly among younger men. Traditional surgical options, such as subcutaneous mastectomy and liposuction, often result in visible scarring and contour deformities. This study introduces the “Stab Flatten” technique, a novel, minimally invasive approach for treating severe gynecomastia, designed to preserve chest aesthetics while minimizing postoperative complications, including scarring and contour irregularities.

Patient concerns:
A 28-year-old male with a 15-year history of progressive bilateral breast enlargement presented with psychological distress and concerns about the cosmetic outcomes of traditional surgery. He sought a minimally invasive procedure to address both physical discomfort and aesthetic concerns, aiming for minimal scarring.

Diagnoses:
The patient was diagnosed with grade III gynecomastia according to Simon classification, characterized by significant glandular hypertrophy and excess skin. Diagnostic imaging and laboratory tests confirmed the absence of underlying medical conditions.

Interventions:
The patient underwent the “Stab Flatten” technique, which involved exclusive liposuction with glandular tissue redistribution. A 4-mm incision was made at the inframammary crease, and power-assisted liposuction was used to flatten fibroglandular tissue without excision. Postoperative care included a compression garment for 6 months.

Outcomes:
At the 6-month follow-up, the patient showed excellent cosmetic results, with significant improvement in breast contour and symmetry. There were no complications such as hematoma, seroma, or nipple-areola complex deformities. The patient reported high satisfaction with the aesthetic outcome, alongside improved psychological well-being and physical comfort.

Limitations:
This study is limited by its single-patient case report, which restricts the generalizability of the findings. Long-term outcomes of the “Stab Flatten” technique require further validation through larger, prospective studies with more diverse patient populations. Additionally, the technique may not be applicable to all grades of gynecomastia or patients with more complex conditions.

Lessons:
The “Stab Flatten” technique offers an effective, minimally invasive alternative for treating severe gynecomastia, providing excellent cosmetic and functional outcomes while minimizing scarring. This method may enhance patient satisfaction and reduce recovery times compared to traditional surgical approaches. However, further studies with larger cohorts are necessary to validate its efficacy and generalizability.
Effect of incentive nursing care on perioperative depression and anxiety in thyroid cancer: A systematic review and meta-analysis
Authors: Cui Ying , Li Yi-Xuan , Zhang Lian-Jie 
Published: January 2025

Background:
This study aimed to investigate the effect of incentive nursing care (ICN) as a supplementary therapy to routine nursing care (RNC) on depression and anxiety (DA) in patients undergoing thyroid cancer (TC) surgery during the perioperative period (PPP).

Methods:
A thorough search was conducted across various electronic databases, including PubMed, EMBASE, Cochrane Library, Chinese Biomedical Literature Database, WANGFANG, and China National Knowledge Infrastructure, spanning from their inception to October 1, 2023. The inclusion criteria were limited to randomized controlled trials focusing on the effects of ICN and RNC on DA in TC surgery during PPP. The primary outcomes assessed were depression, using the Self-Rating Depression Scale, and anxiety, measured by the Self-Rating Anxiety Scale. Additionally, the influence of ICN and RNC on the overall quality of life of the patients was evaluated using the Quality of Life Questionnaire-Core 30. Statistical analysis was carried out using RevMan 5.4 software.

Results:
This meta-analysis incorporated a total of 12 eligible trials encompassing 999 patients. The findings indicated that the combination of ICN and RNC yielded superior outcomes compared to RNC alone across various measures. Specifically, ICN plus RNC demonstrated significant improvements over RNC alone in terms of the Self-Rating Depression Scale (P < .001), Self-Rating Anxiety Scale (P < .001), and Quality of Life Questionnaire-Core 30 (physical function, role function, cognitive function, emotional function, social function, and overall quality of life) (P < .001).

Conclusion:
The findings of this study demonstrate the considerable benefits of implementing ICN and RNC in the management of DA among patients with TC during PPP. However, it is crucial to interpret these results cautiously in light of the aforementioned limitations.
Cardiopulmonary resuscitation status among long-term care residents in Norway
Authors: Skirbekk Vegard , Sundsback Halse Bjørn Atle , Schøyen Seterelv Siri , Selbæk Geir , Langballe Ellen Melbye 
Published: January 2025

AbstractObjectivesNorwegian health authorities require all long-term care institutions to determine and record whether residents should have cardiopulmonary resuscitation (CPR) administered in the case of an emergency. There is a need to better understand variation in CPR-status using population level data to obtain accurate estimates and to understand how it differs by cultural and socioeconomic status.DesignPopulation register based assessments.Setting and ParticipantsThis study investigate the proportions of CPR+ and CPR-2. by age, gender, marital status, primary contact and care needs in a sample that include all residents in long-term care facilities in Oslo aged 50 years or older (N= 11,948) during the period 1stof January 2018 to 31stof December 2023. Everyone in the dataset had CPR status.MethodsDescriptive population-level assessment of health care residents’ registry data and logistic regression analyses.ResultsThe proportion of residents who were CPR+ was slightly below one third (31.4%), with significantly more women (33,2%) than men (27.9%). CPR+ decreased with age (45.9% for those aged 50–66 years, 27.4% for those aged 85-89 years) but rose again for the oldest age group (33.0%, aged 90+). Compared to unmarried individuals and widows or widowers, the proportion of married long-term care residents with CPR+ was lower. Those who had no primary contact or more distant ones (e.g., a lawyer) were more likely to be CPR+. The CPR+ was slightly higher among individuals with comprehensive care needs. However, the differences were only significant for CPR+ among those with comprehensive care needs compared to those with moderate care needs when adjusted for age, gender, and primary contact.Conclusions and ImplicationsOnly one third of long-term care residents in Norway are registered as CPR+. Particularly women and those at younger ages and the oldest old were more likely to be CPR+. The low proportions of CPR+ residents across major segments of Norway’s institutionalized population as well as gender and age distribution will hopefully spark debates about CPR practices.
Enhanced Detection of RNA Modifications inEscherichia coliUtilizing Nanopore RNA004 Technology
Authors: Guo Zhihao , Shao Yanwen , Tan Lu , Lu Beifang , Deng Xin , Chen Sheng , Li Runsheng 
Published: January 2025

AbstractRNA modifications are critical regulators of diverse cellular processes, yet their roles in prokaryotic mRNAs remain poorly understood. Recent advances in Oxford Nanopore sequencing—especially the RNA004 kit—have enabled higher yields, reduced signal-to-noise ratio, and improved read accuracy, making them promising tools for investigating bacterial epitranscriptomes. Here, we presented a comprehensive walkthrough forEscherichia coliRNA modification analysis based on RNA004. Using both native (WT) and in vitro-transcribed (IVT) RNA samples, we first evaluated the Dorado modification detection models (Ψ, m⁶A, m⁵C, and A-to-I). While each model successfully identified known rRNA modification sites, it also generated many false positives, emphasizing the need for careful data interpretation.To address these limitations, we introduced nanoSundial (https://github.com/lrslab/nanoSundial), a new comparative method that leveraged raw current features from WT and IVT samples to detect multiple types of RNA modifications in prokaryotes. We optimized nanoSundial on well-studied rRNA sites and validated its effectiveness with tRNA modifications. Through technical and biological replicate analyses, nanoSundial demonstrated reproducibility exceeding 95% in tRNA, rRNA, and ncRNA regions, albeit with lower reproducibility (∼61%) in mRNA. We further found enrichment of mRNA modifications at the start or end of coding sequences. In total, 190 stably modified CDS regions were identified inE. coli, many of which cluster near the end of highly expressed transcriptional units (TUs) in each operon.Overall, this study highlighted the strengths and limitations of current nanopore-based modification detection methods on bacterial RNA, introduced a robust new comparative tool, and elucidated previously uncharacterized mRNA modification landscapes. Our findings open new avenues for understanding the functional impacts of bacterial RNA modifications and advancing epitranscriptomic research in prokaryotes.