bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Relationship of Serum Fetuin-A Levels with Survival and Mortality in Cardiopulmonary Resuscitation
Authors: COSKUN Abuzer , DEMIRCI Burak , ALTINBILEK Ertugrul , ELGORMUS Cagrı Serdar , MISIRLIOGLU Naile Fevziye , Uzun Hafize 
Published: July 2023

Abstract
Introduction/aims:
Cardiopulmonary arrest can occur with different rhythms in in-hospital and out-of-hospital cases. Early and effective cardiopulmonary resuscitation (CPR) is the most important practice affecting survival in these patients. It was aimed to determine the relation of fetuin-A level, which is a new protein, with the collapse rhythm, prognosis, and mortality in patients who underwent CPR.
Methods:
One hundred four patients who had cardiopulmonary arrest as witnesses in the emergency department were included in prospective study. The patients were divided into four groups according to their collapse rhythm: asystole, pulseless electrical activity, pulseless ventricular tachycardia, and ventricular fibrillation. According to the mortality status, they were divided into three groups as alive, exitus at the emergency department (EXED), and exitus at intensive care unit (EXIC).
Results:
The average age of the patients included in the study was 63.38±12.38 years, 42 (40%) of them were women. Fetuin-A was 0.183±0.18 ng/ml in the EXED group, 0.183±0.22 ng/ml in the EXIC group, and 0.201±0.16 ng/ml in the survival group (p=0.001). The fetuin-A level was the highest in the pulseless electrical activity group with 0.206±0.10 ng/ml and the lowest in the ventricular fibrillation group with a value of 0.183±0.20 ng/ml (p=0.002). There was a strong negative correlation between fetuin-A and rhythm (p=0.001).
Conclusion:
In cardiopulmonary resuscitated patients, the fetuin-A level may be a helpful value in defining prognosis and mortality.
PTSD Symptoms Comparison EMDR and NFB with IPV Survivors: Ex-Post-Facto Study by
Authors: Shaikh Huda 
Published: July 2023

Abstract

Given the prevalence of post-traumatic stress disorder symptoms in intimate partner violence survivors, the need for personalized treatment plans for intimate partner violence (IPV) survivor post-traumatic stress disorder (PTSD) care, and no comparison of eye movement desensitization and reprocessing (EMDR) and neurofeedback therapy (NFB) in response to PTSD care, the researcher aimed to fill the gap in research. Using archival data, a comparison between EMDR therapy and NFB therapy in response to IPV survivor PTSD was analyzed. While there exists support for each modality in the existing literature, there does not exist a comparison of the two in response to IPV survivor PTSD symptoms. The theoretical lens utilized for the study were the theory of neuroscience (TN) and humanistic person-centered theory (PCT). The applied research methodology was quantitative, and the research design was ex-post-facto quasi-experimental. Findings did not support a statistically significant difference between the EMDR group and the NFB group in response to pre and post PTSD symptoms thereby failing to reject the null hypothesis for the main research question of the study. Findings pertaining to the sub-questions however noted a statically significant decrease in pre-and post-mean scores within the EMDR group and the NFB group thereby rejecting the null hypotheses for both sub-questions. The study’s findings suggest that NFB carries similar relief of PTSD symptoms as EMDR does. Several limitations pertaining to the study sample’s characteristics, external factors, and the study’s design exist. For example, given the study’s design, a control group was not present. Recommendations for future research include considering the interventions, ENDR and NFB, during the conceptualization and development of theories to test into practice while also testing the efficacy of other alternative therapeutic interventions that serve to be helpful for PTSD care. By doing so, researchers may be able to develop appropriate, effective, and restorative care for IPV survivors suffering from PTSD symptoms along with a wide variety of other mental health concerns.
Prevalence of Hamstring Tightness in Physically Active and Inactive College Going Students
Authors: Pusegaonkar Rutuja 
Published: July 2023

Abstract
Background
The hamstring is a very important part of flexibility in the human body. The tightness in the muscle is due to the decrease in the ability of the muscle to deform. It is the inability to achieve more than 160º of knee extension when the hip is flexed to 90º due to tightness. The study was carried out to find the prevalence of hamstring tightness in physically active & inactive college-going students.
Method
In this non-experimental cross-sectional study 100 participants were included. The study was performed on normal healthy individuals. The study excluded persons with low back pain and recent hamstring injury within less than 2 months. The tightness was measured by using the AKE test. Three measurements were taken and an average of their reading was noted.
Result
This study concludes that there is an equal prevalence of developing hamstring tightness in both young male & female participants. Hence increased physical activity is advised to prevent musculoskeletal disorders.
Conclusion
The prevalence of hamstring tightness is very high among college-going students in the age group between 18–25 years between the angle 45º-60º.
Magnesium supplementation therapy to prevent cisplatin-induced acute nephrotoxicity in pediatric cancer: A randomized phase 2 trial
Authors: Matsui Motohiro , Makimoto Atsushi , Chin Motoaki , Koh Katsuyoshi , Tomotsune Masako , Kaneko Tetsuji , Morikawa Yoshihiko , Hamada Riku , Yuza Yuki 
Published: July 2023

Abstract
Background:
The present study aimed to examine the effect of magnesium (Mg) supplementation on cisplatin-induced nephrotoxicity (CIN) in pediatric cancer patients.
Methods:
The present phase II, open-label, multicenter, randomized controlled trial enrolled patients aged less than 20 years who were scheduled to receive cisplatin-containing chemotherapy and randomly allocated them at a ratio of 1:1 to a Mg supplementation arm with even-numbered chemotherapy courses (arm AB) or another arm with odd-numbered courses (arm BA). Analysis objects were reconstructed into two groups depending on whether the chemotherapy course had Mg supplementation (group B) or not (group A). The primary outcome was the proportion of chemotherapy courses resulting in elevating serum creatinine per chemotherapy course. The secondary outcomes included efficacies evaluated using other biomarkers and the safety of the Mg supplementation.
Results:
Twenty-eight patients were randomly allocated to either group (16 to arm AB and 12 to arm BA). The baseline characteristics of the groups were similar. There was no significant difference in elevated serum creatinine between the groups (group A: 10% vs. group B: 6%; P = 0.465), nor was any significant difference observed in other biomarkers during any chemotherapy course. The Mg value during chemotherapy was significantly higher in group B than in group A. No adverse events related to magnesium administration were observed.
Conclusions:
The study design, which treated a single chemotherapy course as a study object, failed to detect a statistically significant benefit of Mg supplementation for preventing CIN in pediatric cancer patients.
Trial registration
JRCT (https://jrct.niph.go.jp/) Identifier UMIN000029215 jRCTs031180251.
Vulnerable Server under Bernoulli Vacation and Non-Persistent Customer
Authors: Bharathi J , Nandhini S 
Published: July 2023

Abstract
In this study, computing on the cloud is important to current technologies. CC (Cloud Computing) significantly emphasizes task scheduling as one of its most critical components, we examine an M/G/1 queueing system with two service categories and a Bernoulli vacation subject to the active breakdown. On occurrence of a breakdown , the repair on the service channel starts instantly. Furthermore, the nature of the customer is considered as reneging and balking. Significant performance measures for this queueing model are examined in steady-state using the supplementary variable technique and have also discussed a few special cases of this model. This technique handles each task using a Non-Markovian process before its real allocation to cloud resources. This step comes before the actual assignment of tasks. Numerical illustrations of the effects of various parameters on system performance have also been presented.
Metformin increases the expression of proinflammatory cytokines and inhibits supraspinatus fatty infiltration
Authors: Yoon Jong Pil , Park Sung-Jin , Kim Dong-Hyun , Lee Hyun Joo , Jin Park Eugene Jae , Shim Bum-Jin , Kim Jun Sung , Chung Seok Won 
Published: July 2023

Abstract
Background
After a rotator cuff (RC) tendon tear, the supraspinatus (SS) inflammatory response induces fatty infiltration (FI). Metformin has the effect of regulating the initial inflammatory response of atrophic muscles. Therefore, this study aimed to investigate the effect of metformin use on modulating the expression of proinflammatory cytokines and SS FI in an acute RC tear rat model.
Methods
This study used 26 male Sprague–Dawley rats. Animals were randomly divided into two groups: The metformin group received metformin for 5 days after cutting the RC tendon, and the control group was administered only with saline after cutting the tendon. Metformin 50 mg/kg was intraperitoneally injected for 5 days. Three rats in each group were sacrificed 5 days after SS tendon rupture surgery, and 10 rats in each group were sacrificed 14 days after surgery. The SS was sampled 5 days after SS tendon tear surgery, and the expression of proinflammatory cytokines was measured by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). On day 14 after sampling, histological analysis of the SS was performed using hematoxylin and eosin, Masson’s trichrome, and picosirius red staining.
Results
On day 5 of surgery, the expression values of interferon gamma (increased 7.2-fold, P < .01), tumor necrosis factor alpha (increased 13-fold, P < .05), interleukin-1β (increased 4.7-fold, P < .001), and interleukin-6 (increased 4.6-fold, P < .01) increased significantly in the metformin group compared with those in the control group. As a result of Oil Red O staining, SS FI was significantly suppressed in the metformin group compared with that in the control group (metformin group, 305 ± 50.3 µm2, P < .001; control group, 3136 ± 662.8 µm2, P < .001). In addition, the SS volume of the metformin group was not reduced compared with those of the control group, and the morphology and structure of the SS were better preserved.
Conclusions
The results of this study revealed that metformin can increase the expression of proinflammatory cytokines and suppress SS fat infiltration in delayed sutures.
Computer-Aided Dynamics Intraoperative Navigation in Oral Medicine: A Review
Authors: Jiang Jingang , Zhang Jiawei , Zhang Yongde , Huang Zhiyuan , Qian Kun , Pan Jie 
Published: July 2023

Abstract
Because the oral and maxillofacial areas are adjacent to important organs such as the brain and the eyes and contain a rich network of nerves and blood vessels, this poses a great challenge for surgery of the oral and maxillofacial areas. Traditional treatment protocols rely excessively on the physician's clinical experience and imagination for preoperative planning and do not provide intuitive and reliable intraoperative guidance to the physician during surgery. With the rapid development of medical imaging technology, computer-aided dynamic intraoperative navigation (CADIN) has been introduced into the field of oral and maxillofacial surgery for its ability to accurately locate key anatomical structures intraoperatively and provide the surgeon with a safe surgical boundary in real time. However, the vast majority of surgeries in oral and maxillofacial surgery are still dominated by traditional surgical methods without intraoperative guidance or computer-assisted static navigation (CASN), and CADIN techniques are not widely used. Therefore, this paper presents a systematic review of the application of CADIN technology in the field of oral and maxillofacial surgery from 2018-2023 by searching the PubMed database, discusses the problems faced in the actual clinical application of CADIN technology in the field of oral and maxillofacial surgery, and proposes solutions to improve the accuracy and application scope of CADIN technology in the future.
Caregiving intensity and its association with subjective views of ageing among informal caregivers with different sociodemographic background: a longitudinal analysis from Germany
Authors: Zwar Larissa , König Hans-Helmut , Hajek André 
Published: July 2023

Abstract
We analyzed whether care time, burden and range of caregiving tasks were associated with informal caregivers’ subjective views of ageing (measured as attitudes towards own age (ATOA), subjective age and onset of old age), and whether these associations differed as a function of the caregivers’ age and gender. Adjusted cluster-robust Fixed Effects regression analyses were conducted with gender and age as moderators using data on informal caregivers (≥ 40 years) of the population-based German Ageing Survey (2014, 2017). All aspect of care intensity were associated with changes in subjective views of ageing and this pattern was a function of the caregiver’s age and gender. Care time was significantly associated with higher subjective age. Care tasks were significantly associated with higher ATOA and lower onset of old age. Age moderated the association between burden and ATOA. Gender moderated the association between care time and ATOA and between care tasks and subjective age. Age- and gender-stratified analysis indicated further differences. Our findings suggest to reduce care time, especially among older and female caregivers, to prevent a worsening of views of ageing. However, variety in care tasks seemed to benefit female caregivers, while male caregivers may benefit from more training with care task diversity.
Cerebellar Nuclei Receiving Orofacial Proprioceptive Signals through the Mossy Fiber Pathway from the Supratrigeminal Nucleus in Rats
Authors: Tsutsumi Yumi , Morita Yayoi , Sato Fumihiko , Furuta Takahiro , Uchino Katsuro , Sohn Jaerin , Haque Tahsinul , Bae Yong Chul , Niwa Hitoshi , Tachibana Yoshihisa , Yoshida Atsushi 
Published: July 2023

Abstract
Proprioception from muscle spindles is necessary for motor function executed by the cerebellum. In particular, cerebellar nuclear neurons that receive proprioceptive signals and send projections to the lower brainstem or spinal cord play key roles in motor control. However, little is known about which cerebellar nuclear regions receive orofacial proprioception. Here, we investigated projections to the cerebellar nuclei from the supratrigeminal nucleus (Su5), which conveys the orofacial proprioception arising from jaw-closing muscle spindles (JCMSs). Injections of an anterograde tracer into the Su5 resulted in a large number of labeled axon terminals bilaterally in the dorsolateral hump (IntDL) of the cerebellar interposed nucleus (Int) and the dorsolateral protuberance (MedDL) of the cerebellar medial nucleus. In addition, a moderate number of axon terminals were ipsilaterally labeled in the vestibular group y nucleus (group Y). We electrophysiologically detected JCMS proprioceptive signals in the IntDL and MedDL. Retrograde tracing analysis confirmed bilateral projections from the Su5 to the IntDL and MedDL. Furthermore, anterograde tracer injections into the external cuneate nucleus (ECu), which receives other proprioceptive input from forelimb/neck muscles, resulted in only a limited number of ipsilaterally labeled terminals, mainly in the dorsomedial crest of the Int and the group Y. Taken together, the Su5 and ECu axons almost separately terminated in the cerebellar nuclei (except for partial overlap in the group Y). These data suggest that orofacial proprioception is differently processed in the cerebellar circuits in comparison to other body-part proprioception, thus contributing to the executive function of orofacial motor control.
Characteristics of Adjacent Segment Disease Following Oblique Lateral Interbody Fusion：A retrospective study
Authors: Chen Junxin , Guo Jiandong , Fan Shunwu , Fang Xiangqian , Xu Wenbin 
Published: July 2023

Abstract
Objective: To retrospectively analyze the characteristics and related factors of adjacent segmental disease (ASD) after oblique lumbar interbody fusion (OLIF).
Methods:
This was a retrospective study of the effect of single- or multiple-segment OLIF combined with Wiltse-approach pedicle screw fixation on adjacent segment. For single-segment (n=92), the preoperative and last follow-up measurements of lumbar lordosis angle (LL), disc degeneration grade(DD), disc height (DH), facet joint degeneration grade (FD), and segmental angle (SA) of adjacent segments were recorded and analyzed statistically. For multiple-segment (n=56), based on the presence of ASD at the final follow-up, they were divided into the ASD group (n = 10) and non-ASD (NASD) group (n = 46). Smoking, hypertension, diabetes, osteoporosis, body mass index (BMI), and preoperative radiological parameters, including DD, FD, DH, and SA of both cranial and caudal adjacent segments, LL, and invasion of the facet joint by pedicle screws were recorded and statistically analyzed in both groups.
Results: For single-segment, there was no ASD occurred during the follow-up period. There was a statistically significant difference in the lumbar lordosis angle between preoperative and last follow-up measurements (t=8.2860, P<0.0001), but no statistical difference in the DD, DH, FD, or SA of caudal and cranial segments. For multiple-segment, ASD occurred only in the caudal segment, specifically L5/S1 segment. For the comparison of ASD and NASD, there were statistically significant differences in the preoperative caudal adjacent DD (χ2=12.2500, P=0.0156*) and DH (t=3.6430, P=0.0004*) , age (t=2.1090, P=0.0396), and proportion of patients with osteoporosis (χ2=12.7800, P=0.0003*), but no statistically significant difference in the LL, cranial adjacent DD or DH, and adjacent caudal or cranial FD, SA, proportion of patients with smoking or hypertension or diabetes or invasion of the facet joint.
Conclusion: ASD is less likely to occur in the early stage after single-segment OLIF, while ASD after multiple-segment OLIF mainly occurs at the caudal end, especially when the caudal vertebral body of the surgical segment is L5. Age, preoperative caudal adjacent segment disc degeneration, and osteoporosis are potential factors related to ASD after multiple-segment OLIF.
Pediatric Castleman Disease Combined with TAFRO Syndrome: Two Case Reports and Literature Review
Authors: Du Junye , Zhang Liping , Ma Honghao , Wei Ang , Wang Dong , Zhao Yunze , Zhang Qing , Zhang Rui , Wang Tianyou 
Published: July 2023

Abstract

Objective
To investigate the clinical characteristics, treatment, and prognosis for TAFRO syndrome in pediatric patients.
Method
A retrospective analysis was performed on two patients with TAFRO Syndrome at Beijing Children’s Hospital, Beijing, China. One case was reported in 2019 as Castleman disease (CD) combined with hemophagocytic lymphohistiocytosis (HLH)[1]. The case was examined again from the perspective of TAFRO syndrome, and the follow-up was updated. Clinical features, treatment, and prognosis data of these patients were collected. Also, the published literature on pediatric TAFRO syndrome was reviewed.
Results
Two male patients were enrolled in this study. The ages of onset were 2 years and 9 years, respectively. Both patients presented fever, anemia, thrombocytopenia, lymphadenopathy, hepatosplenomegaly, ascites, bilateral pleural effusion, and limb edema and were diagnosed with idiopathic multicentric CD (iMCD) combined with TAFRO syndrome and secondary HLH. One patient responded satisfactorily to BCD (Bortezomib, Cyclophosphamide, and Dexamethasone) chemotherapy and thalidomide therapy, while the other had an adequate response to tocilizumab; their conditions were controlled by the last follow-up.
Conclusion
Due to the complicated clinical manifestations of TAFRO syndrome and the severe consequences, its diagnosis and treatment are challenging in clinical practice. Multiple chemotherapies combined with immunomodulatory or targeted drugs affect the prognosis of TAFRO syndrome. Also, the co-existing HLH should be noted in the course of the disease.
A detailed investigation of a Generalized Hermite cosh-Gaussian beam propagating in uniaxial crystals orthogonal to the optical axis
Authors: Saad Faroq , Belafhal Abdelmajid 
Published: July 2023

Abstract
In this paper, we study the propagation properties of a Generalized Hermite cosh-Gaussian beam (GHCGB) in uniaxial crystals orthogonal to the optical axis. The analytical propagation equation for the GHCGB at the receiver plane is derived based on Huygens-Fresnel integration. Some analyses are investigated to illustrate the influences of variation in crystal refractive indices, source beam parameters and propagation distance on the beam intensity profiles. Results indicate that a GHCGB would better preserve its intensity profile nearly invariant for a short propagation distance and larger source beam parameters, whereas, the anisotropy of the uniaxial crystal has a significant effect on intensity evolution with increasing the propagation distance. In addition, beam width of output beam can be controlled by adjusting the source beam parameters and uniaxial crystals. According to the results that it will be useful for the control of optical particle.
Nanoencapsulation of Oliveria decumbens Vent. and Basil Essential oils to Investigate Their Antibacterial Function in Vitro and Minced Beef Meat
Authors: Gorzodin Mahdis , Nouri Marjan , Javidi Sahar 
Published: July 2023

Abstract
Beef is a nutritious meat, which possesses biological factors such as protein and micronutrients. The purpose of present research is to investigate antioxidant and antibacterial activities for nanocapsules of Oliveria decumbens Vent. (OEO) and basil (BEO) essential oils in vitro and minced beef. OEO and BEO were extracted and their phytochemicals were identified by gas chromatography. These nanocapsules were produced using freeze drying and combination of maltodextrin and also gum arabic (1:1). Particle size, polydispersity index, encapsulation efficiency (EE), scanning electron microscopy, total phenolic (TPC) and flavonoid (TFC) contents, antioxidant and antibacterial activities, pH, thiobarbituric acid and also sensory were evaluated in vitro compared to free forms. The antibacterial functions were assessed against S. aureus, E. coli, L. monocytogenes, S. typhimurium and P. aeruginosa in minced meat during 10 days of cold storage. Thymol (28.12 %), carvacrol (23.97 %), γ-terpinene (19.56 %) and p-cymene (12.64 %) as well as estragole (48.93 %) and linalool (41.45 %) were the main in OEO and BEO, respectively. The TPC (30.43 to 32.41 mg GAE/g DW), TFC (27.72 to 30.10 mg GAE/g DW) and antioxidant capacity (25.97 to 26.42 %) were determined in free and encapsulated OEO and also antibacterial feature was observed, which were further than BEO. No significant effect was detected by nanoencapsulation on bioactive components and also antioxidant of OEO and BEO, however this process considerably improved antibacterial function (p< 0.05). Finally, OEO and BEO-loaded nanocapsules were applied to promote quality in beef, while potential of OEO nanocapsules was higher.