bluuebunny/crossref_metadata_2025_split huggingface dataset:
RB1 aberrations predict outcomes of immune checkpoint inhibitor combination therapy in NSCLC
Authors: Wang Qian , Yu Tao , Ke Zi-Hao , Wang Fu-Feng , Yin Jia-Ni , Shao Yang , Lu Kai-Hua 
Published: June 2023

IntroductionImmune checkpoint inhibitors (ICI) have changed the treatment of non-small cell lung cancer (NSCLC). Furthermore, compared with monotherapy, ICI combination therapy had better efficacy and partly different mechanism. Therefore, we aim to investigate and improve biomarkers specialized for ICI combination therapy.MethodsWe enrolled 53 NSCLC patients treated with ICI combination therapy and collected their tissue and plasma samples to perform next-generation sequencing (NGS) with a 425-gene panel.ResultsThe line of treatment was the only clinical factor significantly affecting objective response rate (ORR) and progression-free survival (PFS). Surprisingly, classical markers PD-L1 and TMB only had limited predictive values in the ICI combination therapy. Instead, we found RB1 mutation was significantly associated with prognosis. Patients with mutated RB1 had shorter PFS than those with wild RB1 (134d vs 219d, p=0.018). Subsequent analysis showed the RB1 related mutated cell cycle and chromosomal instability were also deleterious to prognosis (103d vs 411d, p&lt;0.001; 138d vs 505d, p=0.018). Additionally, patients with more circulating tumor DNA (ctDNA) had significantly shorter PFS (41d vs 194d, p=0.0043).ConclusionThis study identified that NSCLC patients with mutated RB1 were less sensitive to ICI combination therapy. RB1 mutations and following cell cycle abnormalities and chromosomal instability can potentially guide clinical management.
Efficacy and safety comparison of esketamine-propofol with nalbuphine-propofol for upper gastrointestinal endoscopy in children: a multi-center randomized controlled trial
Authors: Zheng Xiaosu , Huang Jinjin , Wei Sisi , Tao Yingying , Shen Yang , Wang Yanting , He Pan , Zhang Mazhong , Sun Ying 
Published: June 2023

Background and AimsAnesthetics such as propofol, esketamine and nalbuphine are used during the upper gastrointestinal endoscopy to achieve and maintain the desired sedation level. The aim of the study was to evaluate the effectiveness and safety of propofol-nalbuphine and propofol-esketamine in children.MethodsA multi-centered study was performed at three tertiary class-A hospitals. Children between 3 and 12 years old undergoing diagnostic painless upper gastrointestinal endoscopy were included and randomly divided into esketamine or nalbuphine group to estimate the primary outcome of successful endoscope insertion. The patients were given esketamine 0.5 mg/kg and propofol 2 mg/kg intravenously in esketamine group, with nalbuphine 0.2 mg/kg and propofol 2 mg/kg in the nalbuphine group. The primary outcome was success rate for the first attempt of endoscope insertion in each group. Secondary outcomes included the safety of both anesthesia regimens and gastroenterologist's satisfaction. We used the Face, Leg, Activity, Cry and Consolability (FLACC) scale to evaluate the level of pain before and during the procedure and the Pediatric Anesthesia Emergence Delirium (PAED) scale to assess the level of agitation and delirium after awakening from anesthesia.ResultsAmong 246 patients, 200 were randomly included in the final intention-to-treat analysis, with 100 patients in each group. The success rate for the first attempt of endoscope insertion in the esketamine group was higher than the nalbuphine group (97% vs. 66%; P &lt; 0.01). The heart rate and mean arterial pressure after intraoperative administration in the esketamine group were higher than those in the nalbuphine group, while the delirium incidence during awakening was higher in esketamine group (all P &lt; 0.05).ConclusionThe success rate for the first attempt of endoscope insertion of children undergoing upper gastrointestinal endoscopy in the esketamine group was higher than the nalbuphine group, propofol-related hemodynamic changes were reduced accordingly, while the incidence of esketamine-related adverse effects could be high.Clinical Trial RegistrationChinese Clinical Trial Registry: ChiCTR2000040500.
The development and validation of the assessment engagement scale
Authors: Evans Carol , Zhu Xiaotong 
Published: June 2023

IntroductionThe quality of student engagement in assessment within higher education affects learning outcomes. However, variations in conceptions of what quality in engagement looks like impacts assessment design and the way that students and lecturers engage with each other in the assessment process. Given that assessment is an important driver of student engagement in higher education, it is surprising that no specific measures to support understanding of this measure exist. To address this significant gap, we outline the evolution of an assessment engagement scale derived from a research-informed conceptual framework utilizing best practice in assessment and feedback.MethodsWe consider the validity and utility of the assessment engagement scale in supporting students’ understanding of assessment and their role within it using exploratory and confirmatory factor analyses.ResultsThe resultant nine-item assessment engagement scale’s underpinning two factors included: (i) Understanding of the Assessment Context (UAC) including one’s role within it, and confidence in navigating assessment requirement, and (ii) Realising Engagement Opportunities (REO) (i.e., willingness to engage and ability to utilise the assessment context effectively to support one’s understanding). Construct, criterion, and convergent validity of the scale were established.DiscussionThe AES is a powerful tool in promoting dialogue between lecturers and students about what high quality engagement in assessment looks like, and the respective roles of all parties in realising this. Implications for assessment practices are discussed along with the potential of the scale as a predictive and developmental tool to support enhancements in assessment design and student learning outcomes in higher education.
Effect of Shi-Zhen-An-Shen herbal formula granule in the treatment of young people at ultra-high risk for psychosis: a pilot study
Authors: Zhu Hong , Ning Yanzhe , Zheng Sisi , Feng Sitong , Dong Linrui , Jia Hongxiao 
Published: June 2023

IntroductionTo date, there is no conclusive evidence for early interventions on ultra-high risk (UHR) for psychosis. The Chinese herbal medicine is confirmed to be beneficial in improving psychiatric symptoms and cognitive impairments for schizophrenia patients. However, the effect of Chinese herbal medicine on treating UHR patients remains unknown.MethodsEighty UHR patients were recruited from the outpatient department. They were randomly assigned to receive either Shi-Zhen-An-Shen herbal formula granule (SZAS-HFG) combined with aripiprazole placebo or aripiprazole combined with SZAS-HFG placebo for a 12-week treatment. The psychiatric symptoms were assessed using the Structured Interview for Prodromal Syndromes (SIPS). The Trail Making Test part A (TMT-A), Brief Visuospatial Memory Test (BVMT), Hopkins Verbal Learning Test (HVLT), and Continuous Performance Test (CPT) were used to assess cognitive functions. we also employed the Global Assessment of Functioning (GAF) to evaluate social functioning. The linear mixed-effects models were performed to detect the difference in effectiveness between the two groups.ResultsAfter 12-week treatment, both groups showed significant effects of time on SIPS, TMT-A, HVLT, BVMT, and GAF. There was a significant effect of group only on CPT. Moreover, we also found a significant interaction effect on GAF.ConclusionSZAS-HFG can effectively alleviate psychosis symptoms, and improve cognitive impairments and overall functioning as well as aripiprazole.Clinical trial registration: Chinese Clinical Trial Registry, ChiCTR-IOR-17013513.
Health promotion networks in two districts in Bavaria, Germany: an exploratory case study mapping networks with respect to thematic agenda and location
Authors: Fehrmann Annika Marie , Steinbeisser Kathrin , Wolff Andrea R. , Coenen Michaela 
Published: June 2023

IntroductionBuilding networks is an essential part of health promotion. However, network analysis remains relatively unexplored in this field. This study introduces a new technique that maps thematic agendas and geographical locations of health promotion actors.MethodsThis case study used elements of quantitative and qualitative methods to analyse network data. We used empirical data from two networks in Bavaria, a federal state of Germany.ResultsWe identified a total of 55 actors in the first network and 64 actors in the second. We categorized the thematic agenda of actors according to their main field of work: “healthy childhood development,” “healthy middle age phase,” “healthy ageing,” “health equity in all phases of life.” One network showed a significant surplus of actors that focus on “healthy ageing.” We combined and analysed data from both networks collectively. Two districts with no health promotion actors within their geographical borders were identified. To put geographical gaps into context, data about deprivation and age was included.DiscussionResults identified geographical areas with high need for support from health promotion actors. Through comparison of our results with existing literature, we derived potential network strategies for further successful networking. This study adds a new perspective to characterize health promotion networks by mapping them thematically and geographically. The concept can be used to give health promotion organisations relevant insight into network structures. This can improve decision-making processes concerning partnership strategy and finally lead to a positive health impact. Hence, our findings encourage further development of this technique and other networking methods in the field of health equity and health promotion.
Compliance with health protocols in the banking sector facing Covid-19
Authors: Ghavamabadi Leila Ibrahimi , Shabab Mitra , Dehaghi Behzad Fouladi , Hoveizi Farkhondeh 
Published: June 2023

BackgroundThe spread of the coronavirus has become one of the current challenges in the world. Implementing health protocols in the workplace along with informing people who face them, has become a vital issue.ObjectiveThe purpose of this study was to determine the level of compliance with health protocols and measure the level of awareness, attitude and performance of bank employees while facing Covid-19.Materials and methodsThe data collection tool included a checklist and two questionnaires (demographic information and the other on the awareness, attitude and performance of bank staff) regarding the coronavirus.ResultsA total of 199 bank employees from 25 bank branches participated in the study. The results showed that in 24% of the bank branches, the staff did not use face masks. And 100% of the studied bank branches lacked proper ventilation. The mean awareness scores of female employees (94.3) were significantly higher than those of male employees (87.7). Also, the performance of female employees (93.2) was significantly better than male employees (87.2).ConclusionThe results showed that to achieve proper performance in controlling and reducing the covid-19 disease among bank employees and other workers, these items are noteworthy: (1) Providing and training the correct use of protective equipment including face masks. (2) Monitoring for strict implementation of health protocols. Therefore, it is necessary to keep training and information up-to-date due to the new phenomena of this disease.
Mental health knowledge and classroom experiences of school teachers in Aragon, Spain
Authors: Granada-López José Manuel , Ramón-Arbués Enrique , Echániz-Serrano Emmanuel , Juárez-Vela Raúl , Cobos-Rincón Ana , Satústegui-Dordá Pedro José , Navas-Echazarreta Noelia , Santolalla-Arnedo Iván , Nash Michael 
Published: June 2023

BackgroundResearch shows that many mental disorders begin in childhood but are sometimes not diagnosed until later years. School-age children spend much of their time in schools and have daily interactions with school teachers.AimExamine school teachers’ experiences of mental disorders in school going children and adolescents and their associated mental health training needs.Method and sampleA descriptive cross-sectional study was carried out with teachers in Infant-Primary and Secondary Education-Baccalaureate schools.ResultsA convenience sample of 685 teachers responded to the online survey. Participants worked in both urban and rural areas and in Infant-Primary and Secondary Education-Baccalaureate schools. Over half of participants reported classroom experiences of learner mental disorders such as ADHD, anxiety, conduct disorders or autism. Most participants acknowledged a training need, both in recognition of symptoms of mental disorders and in care resources and processes. However, 80% of respondents reported having not received any training in this regard. Participant preferences for training included face-to-face or hybrid – combined online learning. Participants also considered the management of their own mental health to be deficient, therefore any training should incorporate personal mental health awareness and self-help strategies.ConclusionIn Aragón (Spain), teachers of children and adolescents with mental disorders, recognize a need for training in the identification of symptoms and other aspects of mental healthcare, such as availability and access to services. Protocols for early identification and referral would promote mentally healthy school environments and reduce stigma which could be a barrier to timely intervention. In addition, any training should include mental health self-care for teachers.
Case report: Immediate revascularization for symptomatic hepatic artery pseudoaneurysm after orthotopic liver transplantation? A case series and literature review
Authors: Lerut An Verena , Pirenne Jacques , Sainz-Barriga Mauricio , Blondeel Joris , Maleux Geert , Monbaliu Diethard 
Published: June 2023

IntroductionHepatic artery pseudoaneurysm (HAPA), a rare vascular complication that can develop after liver transplantation, is associated with a high mortality rate and graft loss. To salvage the liver graft, immediate revascularization, either through surgical or endovascular intervention, is required. However, currently there is no consensus on the optimal strategy. Here, we report three cases of liver transplant recipients diagnosed with HAPA and treated with immediate revascularization. In addition, we present an overview of HAPA cases described in the literature and make recommendations on how to treat this rare complication.MethodsAll adults transplanted in our center between 2005 and 2021 were retrospectively reviewed. Literature search was done in PubMed for original studies between 1980 and 2021 reporting early hepatic artery (pseudo) aneurysm after liver transplantation requiring either surgical or endovascular intervention.ResultsFrom a total of 1,172, 3 liver transplant patients were identified with a symptomatic HAPA and treated with immediate revascularization. HAPA occurred 73, 27, and 8 days after liver transplantation and was treated with immediate revascularization (two surgical and one endovascular intervention). Literature review identified 127 cases of HAPA. HAPA was managed with endovascular therapy in 20 cases and by surgical intervention in 89 cases. Overall reported mortality rate was 39.6%, whereas overall graft survival was 45.2%.ConclusionImmediate surgical or radiological interventional excision and prompt revascularization to salvage liver grafts is feasible but still associated with a high mortality.
Edukasi Pemanfaatan Rebusan Daun Sirih Sebagai Obat Kumur Dalam Upaya Menjaga Kebersihan Gigi dan Mulut Pada Remaja
Authors: Sayekti Fitria Diniah Janah , Dewangga Vector Stephen , Rofifah Karina Winda , Devi Alvindo Thiananda , Santosa Lingka Elliesia Putri , Putri Sherrin Karina , Ramadhani Yayi Aullia 
Published: June 2023

Pemasalahan gigi dan mulut timbul akibat rendahnya perilaku pemeliharaan kesehatan gigi dan mulut. Menurut Riskesdas (2018) penderita penyakit gigi dan mulut pada remaja cukup tinggi, dengan permasalahan gigi dan mulut di perkotaan lebih rendah (57,2%) dibandingkan penduduk perdesaan (58,2%). Salah satu cara menjaga kebersihan gigi dan mulut adalah menggunakan obat kumur. Daun sirih merupakan tanaman obat tradisional yang mengandung berbagai senyawa yang bersifat antibakteri, dan antijamur yang kuat. Penyuluhan bertujuan untuk meningkatkan pengetahuan dalam menjaga kebersihan gigi dan mulut menggunakan obat kumur alami rebusan daun sirih. Sasaran penyuluhan adalah remaja anggota Karang Taruna dukuh Plumbon, Plumbon, Mojolaban, Sukoharjo, Jawa Tengah dilaksanakan secara online, metode ceramah dengan tahap identifikasi, perencanaan, pelaksanaan. Hasil penyuluhan sangat baik dengan presentase kehadiran 80% (20 peserta), antusiasme peserta dibuktikan dengan 11 pertanyaan yang diajukan kepada pemateri. Pada uji non parametrik Wilcoxon hasil nilai pengerjaan pre-test dan post-test menunjukan (p) < 0,05, dapat disimpulkan ada perbedaan yang signifikan antara hasil pre-test dan hasil post-test, dengan peningkatan hasil pengerjaan 15 peserta (75%).
PENERAPAN MODEL PEMBELAJARAN PAIRED STORY TELLING DALAM MENINGKATKAN KREATIVITAS MEMBACA SISWA KELAS VIII SMP NEGERI 3 KOTA BAUBAU
Authors: Arwati Andi Lucy 
Published: June 2023

Tujuan dari penelitian ini yaitu untuk meningkatkan kreativitas membaca siswa pada pelajaran Bahasa Indonesia dengan menerapkan model pembelajaran Paired Story Telling siswa kelas VIII. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) yang dilakukan dalam dua siklus, pada tiap siklusnya terdapat empat komponen yaitu perencanaan, pelaksanaan tindakan, observasi dan refleksi. Teknik pengumpulan data dalam penelitian dengan observasi dan tes. Subjek penelitian ini adalah siswa kelas VIII SMP Negeri 3 Baubau yang terdiri dari 21 siswa yang terdiri dari 9 laki-laki dan 12 perempuan. Hasil penelitian menunjukan bahwa pada awal tindakan sebelum diterapkan model pembelajaran paired story telling, nilai rata-rata yang diperoleh siswa 5,1%, dalam keterangan kurang dengan presentase siswa yang tuntas yaitu 29% yang artinya sebanyak 6 orang siswa tuntas sedangkan 15 siswa yang tidak tuntas dengan presentase 71% dan nilai kreativitas bercerita siswa meningkat pada siklus I, nilai rata-rata siswa menjadi 6,9% dengan kategori baik dengan presentase siswa yang tuntas 57% yang artinya sebanyak 12 orang siswa yang tuntas sedangkan 9 siswa yang belum tuntas dengan presentase 43% dan semakin meningkat pada siklus II dengan nilai rata-rata siswa 7,8% dengan keterangan baik dengan presentase siswa yang tuntas sebesar 86% yang artinya sebanyak 18 siswa yang telah tuntas sedangkan 3 orang siswa yang tidak tuntas dengan presentase 14%.
MEMBANGUN NILAI KEPERCAYAAN TERHADAP TEMAN SEBAYA DI LINGKUNGAN PENDIDIKAN (Studi Kasus Siswa SMP Negeri 7 Baubau)
Authors: Taherong Rosmawati , Kurniawan Unhaluddin T. , Febriani Yuyun 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan bagaimana bentuk nilai kepercayaan terhadap teman sebaya dalam lingkungan pendidikan dimana kepercayaan sangat dibutuhkan dalam rangka menjalin hubungan interpersonal dan melakukan adaptasi. Penelitian dilakukan dengan model deskriptif kualitatif, dalam pengumpulan data sampel ditentukan melalui pusposivesampel melalui responden terpilih, yang kemudian dilakukan dengan melakukan wawancara mendalam terhadap kepercayaan teman sebaya. Hasil penelitian menunjukan (1) Untuk menumbuhkan rasa percaya serta pembentukan karakter seseorang harus memiliki nilai-nilai kepercayaan, yaitu: Jujur, Bertanggung Jawab, Disiplin, serta Suka Menolong. (2) kepercayaan merupakan suatu fenomen dinamis yang terjadi secara intrinsic pada suatu keadaan alamiah, dimana kepercayaan merupakan hal yang menyangkut masalah mental didasarkan oleh situasi seseorang dan konteks sosialnya.
PERANAN PEMBELAJARAN PAI DALAM MENGANTISIPASI KENAKALAN PESERTA DIDIK DI SMP NEGERI 1 POLEANG KABUPATEN BOMBANA
Authors: Burhanuddin Burhanuddin , Ali Marzuki Made , Musgar Musgar 
Published: June 2023

Penelitian ini bertujuan untuk mendeskripsikan peranan pembelajaran PAI dalam mengantisispasi kenakalan peserta didik di SMP Negeri 1 Poleang Kabupaten Bombana. Penelitian ini merupakan penelitian deskriptif kualitatif jenis studi kasus. Data penelitian diperoleh dari observasi, wawancara dan dokumentasi. Teknik analisis data yang dilakukan yaitu reduksi data, display data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa faktor-fakor penghambat dalam peningkatan pendidikan Islam pada siswa di SMP Negeri 1 Poleang: (1) perilaku remaja yang selalu melanggar norma/tata aturan, kontribusi yang menyebabkan terjadinya kenakalan peserta didik, (2) Fungsi dan Pendekatan Pendidikan Agama Islam dalam mengatasi kenakalan peserta didik di SMP Negeri 1 Poleang: 1) Pendekatan moral dan akhlak pada peserta didik, fungsi pendidkan Agama Islam pada peserta didik terdiri (fungsi pengembangan, fungsi penyaluran, perbaikan, pencegahan, penyesuaian, sumber nilai. 2) Pendekatan-pendekatan pendidikan pada peserta didik (pendekatan pengalaman, pendekatan pembiasaan, pendekatan emosional, pendekatan rasional, pendekatan fungsional, pendekatan keteladanan) dan (3) Peranan Pendidikan Agama Islam dalam mengantisipasi kenakalan peserta didik di SMP Negeri 1 Poleang: Penerapan ajaran islam sebelum anak lahir (dalam kandungan), pembinaan setelah lahir terdiri (pendidikan iman, pendidikan akhlak, pendidikan jasmani, pendidikan intelektual (akal), pendidikan psikis, pendidikan sosial, pendidikan seksual.
Analisis Framing Nilai Anti Korupsi dalam Film Jimpitan
Authors: Nafi Ma'la Ahmad Azka , Asiyah Siti 
Published: June 2023

The Jimpitan film is one of the films that won the ACFFest event organized by the Corruption Eradication Commission. The Jimpitan film contains a story that represents the value of anti-corruption through the story of a farmer's struggle to replace the people's jimpitan rice. The focus of this study is to find out how the framing of anti-corruption values in the Jimpitan film. The anti-corruption value indicators are taken from the Nine Anti-Corruption Values formulated by the Corruption Eradication Commission. This research is a qualitative type of library research with Framing Analysis theory from Zong dang Pan & Gerald M. Kosicki. The results of the study show that the Jimpitan film contains four anticorruption values, namely responsibility, simplicity, independence and courage. This value is conveyed by the author through character building, storytelling and describing the efforts made by Poniman in replacing jimpitan rice.
Aktualisasi Metode Dakwah Milenial Menghadapi Tantangan Perubahan Sosial Masyarakat
Authors: Abrori Abrori , Alnashr M. Sofyan 
Published: June 2023

Perubahahan sosial yang diakibatkan oleh perkembangan teknologi dan perubahan gaya hidup menimbulkan problem sosial yang semakin konpleks. Aktivitas dakwah harus mampu menjawab perubahan sosial ini supaya tetap ajaran Islam dapat disampaikan sesuai dengan perkembangan zaman. Hal ini berarti pula bahwa keharusan adanya perubahan pola dan model dakwah terutama bagi generasi milenial. Artikel ini bertujuan memaparkan upaya aktualisasi metode dakwah milenial dalam menjawab tantangan perubahan. Penelitian ini merupakan penelitian kualitatif deskriptif dengan pendekatan pustaka. Pengumpulan data melalui studi dokumen tentang dakwah di era milenial kemudian dianalisis dengan analisis interaktif Miles dan Huberman. Hasil penelitian menunjukkan bahwa metode dakwah yang dilakukan oleh para da’i sudah menampakkan beragam metode yang aktual. Metode dakwah digital menjadi salah satu metode aktual yang banyak dilakukan untuk menangkap sasaran generasi milenial. Selain dakwah digital, metode dakwah tradisional dan struktural masih sangat penting untuk dilakukan. Konten dakwah milenial perlu disajikan lebih menarik, interaktif, dan kontekstual sehingga tujuan dakwah dapat terwujud dengan baik.