bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macroseismic intensity attenuation models calibrated in Mw for Italy
Authors: Capera Augusto Antonio Gomez , Santulin Marco , D'Amico Maria Clara , D'Amico Vera , Locati Mario , Meletti Carlo , Varini Elisa 
Published: May 2023

Abstract
This study aims at developing new macroseismic intensity attenuation models valid for Italy by exploiting the most updated macroseismic dataset and earthquakes catalogue, as well as the information obtained from a critical analysis of the most recent models in the literature. Several different attenuation models have been calibrated as a function of the moment magnitude (Mw) and epicentral distance from 16.260 intensity data points, that are related to 119 earthquakes occurred after 1900. According to trends and residuals analysis, the preferred calibrated intensity (I) attenuation function is a Log-Linear model for epicentral distance (r in km) and a linear model for Mw as:
I = 1.81 - 2.61 LogR - 0.0039R + 1.42Mw
with R=(r2+(9.87)2)0.5; the estimated standard deviation is σ=0.75.
Also noteworthy is an unusual multiplicative model for macroseismic intensity attenuation which performs as well as the best model and shows higher sensitivity to physical parameters, such as focal depth and magnitude, especially in the epicentral area. Performance of all calibrated models was also checked on an independent set of 15 post-1900 Italian earthquakes.
At-site flood frequency analysis in Brazil
Authors: Valentini Marlon Heitor Kunst , Beskow Samuel , Beskow Tamara Leitzke Caldeira , de Mello Carlos Rogério , Cassalho Felício , Silva Maria Eduarda Silva da 
Published: May 2023

Abstract

Governmental research agencies from Australia, Austria, Germany, Italy, Spain, and UK have suggested the use of specific 2- and 3-parameter Probability Density Functions (PDFs) to estimate the magnitude and frequency of annual maximum streamflow (AMS). There are no guidelines in Brazil concerning the most indicated PDFs to model AMS, however, two- and three-parameter PDFs have been used. Considering the worldwide promising results when using multiparameter PDFs, we were encouraged to evaluate ten candidate PDFs to model AMS at the scale of a continental country. The methodology of this study consisted of the: acquisition of streamflow data for the Brazilian territory and organization of the AMS series; screening of AMS series considering temporal and statistical criteria; fit of the following PDFs to the AMS series based on the L-moments method: Gumbel, Gamma, Generalized Logistic, Generalized Normal, Generalized Pareto, 3-parameter Log-Normal, Pearson type 3, Generalized Extreme Value, Kappa, and Wakeby; quantile estimation; and PDF performance according to the Filliben test and the Relative Absolute Error (RAE). Out of 3,826 AMS series initially considered, 707 were effectively used for the analysis. We concluded that: a) Gumbel and Gamma provided poor performance; b) the multiparameter PDFs (Wakeby and Kappa) outperformed the other PDFs to model AMS in Brazil; c) Gumbel and Generalized Extreme Value had the highest RAE values for quantile estimate; and d) this study has potential to contribute with the scientific advances reported in literature and can offer insights into the most indicated PDFs for the development of national guidelines.
Exploring Thermal Annealing to Study Interaction of Calmodulin Protein with Carbon Nanotube:A Molecular Dynamics Simulation Approach
Authors: Mehta Dwij , Negi Sunita , Rajaraman Ganesh 
Published: May 2023

Abstract
Carbon nanotubes have shown their importance from their vast applications in all different fields such as electronics, sensors, drug delivery, air-water filtration and catalyst support this research aimed to investigate the potential application of an armchair single-walled carbon nanotube in the field of biomedicine by studying its interaction with calmodulin protein (3CLN). Through Molecular Dynamics simulations, it was found that the interaction only takes place at elevated temperatures, such as 500 K. Our research involved examining the interaction between Calmodulin protein and carbon nanotube through a thermal annealing process that entailed increasing the temperature from 300 K to 500 K, then cooling back to room temperature. We conducted molecular dynamics simulations using NAMD and VMD to study this process. Although we intended to investigate whether any significant interaction occurs at 300 K, we observed something unexpected during the experiment. Specifically, at the end of the simulation, we observed some fascinating dynamics during the annealing process, where the protein wrapped around the carbon nanotube, forming a stable corona-like structure. This was different from what we had initially set out to investigate. This structure remains intact even after cooling the structure to room temperature as well. The observed structure is important from the point of view of application of the carbon nanotube in the drug delivery applications.
A solitary finger nodule with a papulovesicular hands and feet eruption: a complicated human Orf virus infection
Authors: Salvi Martina , Tiecco Giorgio , Rossi Luca , Venturini Marina , Castelli Francesco , Quiros-Roldan Eugenia 
Published: May 2023

Abstract
Introduction and aims: Orf virus (ORFV) is the pathogen responsible for Orf, a zoonotic viral infection that can be spread to humans from sheep and goat. Here, we present a case report of an ORFV infection complicated by an immune-related reaction to raise awareness of this under-recognized disease.
Case report: A 51-year-old woman presented with a 1-week history of a single asymptomatic swelling nodule with grey necrotic centre and red outer halo on her index finger. At physical examination, a pruritic papulovesicular eruption was also assessed on her hands and feet. Laboratory tests were within normal ranges and no past medical history was reported. She reported a recent contact with a goat which had a similar nodule in her mouth. The lesions biopsies were compatible with Orf virus infection complicated by erythema multiforme. The lesions spontaneously resolved within the next 2 weeks.
Conclusions: Clinicians should be aware of the primary presentation and the potential complications that may occur in case of Orf virus infection. Erythema multiforme is the most frequently reported Orf-induced immunological diseases and, although histopathological examination might help, generally, clinical and epidemiological characteristics are enough to achieve a prompt diagnosis. Both primary and secondary lesions generally auto-resolve without needing any unnecessary overtreatment.
Single dose intravenous ondansetron induces QTc prolongation in adult emergency department patients: is it predictable and persistent? A prospective observational study
Authors: Rukerd Mohammad Rezaei Zadeh , Shahrbabaki Fatemeh Rafiei , Movahedi Mitra , Honarmand Amin , Pourzand Pouria , Mirafzal Amirhossein 
Published: May 2023

Abstract
Background Ondansetron is one of the most routinely used drugs in the emergency department (ED) for treating nausea and vomiting, particularly in intravenous (IV) form. Nevertheless, it has been shown to prolong QT interval and increase the risk of fatal ventricular dysrhythmias. The accurate prediction of QTc interval prolongation induced by just a single-dose IV ondansetron in the ED remains unclarified in the literature. This study further evaluated the associations between IV ondansetron dosage and subsequent QTc prolongation.Methods In this prospective observational study, a total number of 106 patients presenting to the ED in a 3-month period with nausea and vomiting treated with IV ondansetron were enrolled. QTc intervals were measured at baseline (QTc0), 30 minutes (QTc30) and 60 minutes (QTc60) following a single-dose administration of ondansetron at 4 or 8 mg doses.Results In the multivariable logistic regression, ondansetron IV dose and QTc0 were independently associated with QTc60 > 480msec. The area under curves (AUC) for prediction of prolonged QTc60 were 0.71 and 0.64 for dosage and QTc0, respectively. There was a 100% sensitivity for QTc0 = 400msec to predict QTC60 < 480msec, while QTc0 > 460msec predicted QTC60 > 480msec with 98% specificity. Each msec increment in QTc0 increased the likelihood of prolonged QTc60 by 3%, while increasing the single dose of 4mg to 8mg increased prolonged QTc60 odds by 33%.Conclusions Based on our results, single doses of up to 8 mg ondansetron could be safely injected for patients with no risk factors for QTc prolongation and initial QTc of 400msec or less. Above this QTc cutoff, using the 4mg dose instead of 8mg as a precaution may be advisable if the baseline QTc is not prolonged and ondansetron administration is necessary.
Rheological and Molecular Dynamics Simulation Studies of the Gelation of Human Serum Albumin in Anionic and Cationic Surfactants
Authors: Nnyigide Tochukwu Olunna , Hyun Kyu 
Published: May 2023

Abstract
We report the gelation of human serum albumin (HSA) of 5–12 wt.% concentrations in 0–0.15 M aqueous solutions of a cationic surfactant, cetyltrimethylammonium bromide (CTAB), or an anionic surfactant, sodium dodecyl sulfate (SDS), under isothermal and nonisothermal conditions. Under both conditions, the initial increase in the CTAB concentration (up to 0.075 M) accelerated HSA gelation (marked by decreasing gel times (tgel) for the isothermal case or gel temperatures (Tgel) for the nonisothermal case), whereas increasing the SDS concentration inhibited HSA gelation (i.e., increasing tgel or Tgel). The increase and decrease in HSA gelation by CTAB and SDS, respectively, reached a maximum at a surfactant/protein molar ratio of 100. Rheological properties, i.e., storage modulus (G’) and loss modulus (G’’), exhibited mechanically stable behavior of HSA/CTAB gels over the covered concentration range, whereas HSA/SDS gels exhibited decreasing mechanical properties with increasing SDS concentrations. Molecular dynamics simulation showed that the greater rate of the unfolding of the HSA structure in CTAB than in SDS was behind the rapid gelation kinetics of HSA in CTAB compared with SDS. Our result establishes that cationic CTAB and anionic SDS surfactants exert wide-ranging control over the rheological and kinetic properties of HSA hydrogels.
Infectivity of human group B adenovirus to cells from different species
Authors: Yuan Liu , Mengke Wang , Yuanqing Qu , Zonghai Hu , Jie Xiong , Lu Wang , Lu Liu , Wenbo Wang 
Published: May 2023

Abstract
Adenovirus is a world public health problem that causes symptoms of respiratory, intestine, urethra and bladder, eyes and liver. The aim of this study is to observe the infectivity of adenovirus to cells from different species, which will provide evidence for finding potential adenovirus infecting animals and nature hosts. 10 cells from different species were infected with human adenovirus (HAdV) in group B (HAdV-3, HAdV-7, HAdV-14 and HAdV-55). Results showed that all the cells supported HAdV-55 entry and hexon protein expression. Increased viral DNA levels were observed in HEp-2, Vero, MDCK, PK15, OAR-L1, MDBK, and F81 cells, while not in CHO, NIH3T3, CT26WT and BHK21 cells. Infectious viral particles were produced in HAdV-55 infected HEp-2, Vero, MDCK, MDBK and PK15 cells, and in HAdV-7 infected HEp-2, Vero, MDCK, F81, MDBK, PK15 and OAR-L1 cells. Conclusively, it is possible to find animals that might be infected by human adenovirus through screening of susceptible cells, and the prevalence of human adenovirus in these animals deserves further investigation.
The Mediating Role of e-Health Literacy in Self-efficacy and Depressive Symptoms among Chinese College Students
Authors: Wang Yanan , Wang Tiantian , Wang Yaning , Liu Yitong , Xi Hanqing , Zhong Yaqin 
Published: May 2023

Abstract
Background Depressive symptoms is a relatively common mental disorder, which can lead to serious physical, psychological, and social problems. This study aimed to explore the associations between self-efficacy, e-Health literacy and depressive symptoms among Chinese college students and to evaluate the effect of e-Health literacy as a potential mediator.
Methods By using a cluster sampling method, 1500 students from two universities were recruited in Nantong City, China. Participants' demographic characteristics, self-efficacy, e-Health literacy and depressive symptoms were collected. OLS was used to explore the associations between variables and the Karlson Holm and Breen method was used to estimate the mediation effect.
Results A total of 1388 valid questionnaires were collected. The prevalence of depressive symptoms among the sample was 50.29%. Higher self-efficacy and e-Health literacy were all significantly associated with lower levels of depressive symptoms. E-health literacy partially mediated the association between self-efficacy and depressive symptoms, accounting for 26.6% of the total effect.
Conclusion Our results indicated that self-efficacy was negatively associated with depressive symptoms in college students. E-health literacy partially mediated the association between self-efficacy and depressive symptoms. Interventions for college students should include increasing self-efficacy, e-health literacy to attenuate depressive symptoms.
A four steps protocol for in vitro propagation of Eugenia uniflora L. (Myrtaceae)
Authors: Franco Lucas Barasuol , Hermann Bruna Ronchi , Fritsche Yohan , Stefenon Valdir Marcos 
Published: May 2023

Abstract

The maintenance of forest formations under a scenario of climatic changes and unsustainable anthropic use of natural resources is vital for the future of mankind. In this context, there is a rising agreement that underutilized crops may be important for the future production of food, as they tend to be more adapted to stressful conditions than domesticated crops.Eugenia unifloraL. (Myrtaceae) is a key species in different forest formations with ecological, economical, and medicinal importance. The present work aimed at establishing anin vitroculture procedure for the mass micropropagation ofE. unifloragenotypes through the organogenesis route. Nodal segments fromin vitrogerminated seeds were introduced in a semi-solid medium for organogenesis establishment and posteriorly cultivated in immersion systems for shoot development and rooting. Different culture media, plant growth regulator concentrations, and immersion systems were tested. The protocol provided in this study may be helpful for the mass production of seedlings for degraded areas recovery or commercial orchard implementation, as well as in genetic improvement programs forE. uniflora.
Systematic Analysis of the Aberrances and Functional Implications of UPR in Hepatocellular Carcinoma
Authors: Xu Xuan , Huang Shaozhuo , Gao Na , Liao Weixin , Chen Yongjian , Dai Shixue 
Published: May 2023

Abstract
Background
Unfolded protein response (UPR), an orchestrating adaptive mechanism activated by endoplasmic reticulum (ER) stress, plays an instrumental protumoral roles in several kinds of cancers, and high unfolded protein response is correlated to poorer prognosis and malignant hallmark. Considerable evidence indicates that UPR induced by oncogenic conditions is a distinguishing feature of cancer.
Methods
Bioinformatics mining was carried out by using the public pancer data of TCGA and other public databases to analyze the differential gene expression profiles of the patients and Cox regression analysis to find out the differentially expressed endoplasmic reticulum stress related genes with prognostic value. ER-stress Potential Index (EPI) was defined to computationally dissect the UPR trends via gene set enrichment analysis using R package ‘GSVA’. Combined with TCGA and GEO databases, the clinical characteristics of EPI were comprehensively analyzed in LIHC. Virtual screening was performed to find out potential compounds targeting STC2, which was a good diagnostic marker and pharmacological target towards endoplasmic reticulum stress in LIHC.
Results
Pan-cancer analysis results showed that unfolded protein response pathway was generally positive associated with poor prognosis of patients across different cancer types. It would be an important and ubiquitous mechanism in different tumors. High EPI was positive associated with tumor malignant phenotype, including higher death rate, recurrence rate, metastatic risk, larger tumor size and other undesirable aggressive clinical traits. In addition, EPI was also responsible for immune evasion via upregulating the expression of immunosuppressive gene and facilitating the production of pro-inflammatory and immunomodulatory cytokines. Besides, EPI played pivotal role in liver cancers’ resistance of chemotherapy and therapeutic targeting UPR would be enhance the anti-tumor effectiveness. STC2 would be a good diagnostic marker and pharmacological target in LIHC. Through virtual screening, we found that flavonoids compounds could be a good compound targeting STC2. Flavonoids could become a good pharmaceutical therapeutic candidate in unique or adjuvant therapeutic approaches toward LIHC.
Conclusion
EPI was associated with subtypes and clinical features and providing new insight into tumor biology and can guide efficient pharmalogical intervention of unfolded protein response to help patients.
A Non-Flammable Flexible Aluminum-Lithium Dual-Ion Battery with a Wide Temperature Range Based on Ionic Liquid Electrolytes
Authors: Wang Lili , Yuan Zeyu , Zhao Lianjia , Chen Ruoyu , Li Dongdong , Han Wei 
Published: May 2023

Abstract
With the rapid development and increase in popularity of electric vehicles and wearable devices, battery safety in the field of energy storage has become an increasingly strong focus. Aluminum-ion batteries (AIBs) are gaining attention as energy-storage systems that are low cost with high levels of safety and high theoretical energy density. However, to date, the dense alumina passivation layer on the aluminum anode surface and the slow kinetic performance of the IL (ionic liquid) electrolyte has rendered their performance unsatisfactory. We have reported on a new type of lithium–aluminum battery that maintains a certain discharge performance under destructive conditions such as continuous bending, high- and low-temperature environments, and shearing. The prepared AlLi metal battery achieved a stable cycle of 130 mAh g− 1 specific capacity and approximately 260 Wh kg− 1 energy density at a wide voltage platform of 2 V and a test temperature of 25°C. The batteries did not experience combustion and this product can meet the current demand for flexible and safe batteries. We also analyzed the reaction mechanism and principle of this Al–Li cell based on density functional theory and conducted ex situ XRD and XPS tests to elucidate the storage mechanisms of the Al-Li battery.
Genetic variations and character association among CGMS based chilli F1 hybrids for morphometric, fruit quality, and yield traits in shallow basaltic soils of India
Authors: Khapte Pratapsingh Suresh , Ponnam Naresh , K.M. Boraiah , Wakchaure G.C. , S. Gurumurthy 
Published: May 2023

Abstract
Chilli (Capsicum) is in high demand as a vegetable and spice throughout the world. Fruits have wider applications in the food, phytogenic feed, cosmeceutical and pharmaceutical industries. As surge for their uses is increasing, there is a need to develop F1 hybrids to enhance yields with tolerance/ resistance to major threatening diseases. The present investigation was carried out to study the diversity of morphometric, fruit quality and yield traits, and their reaction to chilli leaf curl disease among fourteen CGMS based high yielding F1 hybrids developed at ICAR-IIHR, Bangalore, India. The hybrids Arka Nihira, Arka Yashasvi, H-25, H-26, and Arka Tanvi excelled for the majority of the evaluated traits in terms of yield enhancement. The yield increment potential in these hybrids is attributed to higher morphometric, fruit biometric and physiobiochemcial traits (NDVI and chlorophyll content). In relation to the local check, hybrid Arka Nihira exhibited enhanced green fruit yield by about sixty-two percent. The cluster plot partitioned these hybrids into four primary groups, revealing genetic similarities and differences among the hybrids. Further, character association indicates that the traits such as days to 50 percent flowering, plant spread, fruit girth, and the number of fruits per plant can be leveraged as indirect selection indices for green fruit yield while selecting a commercial hybrid cultivar in chilli breeding programs. As a result, the hybrids Arka Nihira and Arka Tanvi, in particular, have the potential to be commercial cultivars in terms of yield, agronomic characteristics, and leaf curl disease tolerance in shallow basaltic soils of the Deccan plateau of India.
Microstructure evolution of S-TC4 titanium alloy blade preformed by cross wedge rolling
Authors: Li junling , Hang Sun , Li Xuan , Chen Ping , Wang Baoyu 
Published: May 2023

Abstract
This paper proposed to use cross wedge rolling (CWR) to manufacture sintered TC4 (S-TC4) titanium alloy blade preform prepared by powder metallurgy technology. The hot uniaxial compression tests, CWR experiments and numerical simulation were carried out to investigate the influence of forming parameters on microstructure evolution. The results showed that the pattern of stress-strain curve is typical featured of work hardening and dynamic softening, and the Arrhenius equation was determined to describe the high temperature flow behavior of the studied S-TC4 alloy. In regard to microstructure evolution, the volume fraction of alpha phase \({f}_{\alpha }\) increases and then decreases radially from inside to outside, and the lamellar alpha phase was equiaxialized by to the shear and torsion stress. And increasing the initial forming temperature T was not conducive to the preservation of the alpha phase, and both the volume fraction of alpha phase fα and average thickness of lamellar alpha phase lα are negatively correlated with the rolling speed n and area reduction \(\phi\). Moreover, the maximum initial forming temperature, rolling speed and area reduction are 940℃, 10r/min and 60%, respectively, in order to achieve the best match between strong plasticity and thermal.