bluuebunny/crossref_metadata_2025_split huggingface dataset:
“When You Carry a Lot”: The Forgotten Spaces of Youth Prison Schooling for Incarcerated Disabled Girls of Color
Authors: Cabral Brian , Annamma Subini Ancy , Morgan Jamelia 
Published: June 2023

Context: The Crouse decision from 1838 laid precedent to the positioning of prisons as sites where education takes place. With a massive expansion of youth carceral facilities since then, alongside the prison-schools within them, we continually rely on prison-school spaces as places where youth are brought to experience education and punishment. While the wider population of youth who are incarcerated in the United States has significantly reduced since the year 2000, the reduction of incarcerated Girls of Color has not. Many incarcerated Girls of Color are also disabled. Thus, it is within this context that we explore the prison-school space as a site that is intended to provide robust educational opportunities. Focus of Study: In this article, we repositioned disabled incarcerated Girls of Color as knowledge generators and as experts well positioned to describe existing prison-school practices and alternatives to prison-school. Through the conceptual frames of forgotten places and the destructive practices within, we focused on the lived experiences of disabled incarcerated Girls of Color in SYRAD, a Midwestern maximum-security youth prison, to address our main research question: What are the education experiences of disabled Girls of Color in prison-schools? Research Design: Our qualitative study is part of a larger project that included 14 disabled incarcerated Girls of Color. Throughout the year, the girls were enrolled in a credit-bearing course with the principal investigator and research team. Our full corpus of data included interviews with the girls (23) and adults in the youth prison (6); classroom observations (25); education journey maps (10); focus groups (4); field notes (20); and classroom artifacts (21). For this study, we mainly focused on the initial interviews with the girls in which they discussed topics related to their experiences in a prison and prison-school. Conclusions/Recommendations: Our analyses showcased that prison-schools do not offer robust educational opportunities as claimed by the Crouse decision. Instead, the collective experiences of disabled incarcerated Girls of Color in our study were saturated with destructive prison-school practices. Three main findings emerged in our analysis that framed prison-school educational spaces as “concentrated sinks” of destructive practices: (1) curricular reduction, (2) remedial pedagogy, and (3) relational antagonism. Further, the girls offered robust explications on why naming and describing destructive practices is important, especially “when you carry a lot” as an incarcerated disabled Girl of Color in a forgotten place of prison-school. These findings led us to the need for an eventual abolition of prisons and prison-school spaces that can be anchored in a DisCrit abolitionist imaginary in the meantime.
REALizing and improving management of stable COPD in China: results of a multicentre, prospective, observational study (REAL)
Authors: Yang Ting , Cai Baiqiang , Cao Bin , Kang Jian , Wen Fuqiang , Chen Yahong , Jian Wenhua , Wang Chen 
Published: June 2023

Background: Chronic obstructive pulmonary disease (COPD) management in China is far from adequate; underdiagnosis and undertreatment are major barriers to optimal care and improved patient outcomes. Objective: To generate reliable information on COPD management, outcomes, treatment patterns and adherence, and disease knowledge in China in a real-world setting. Design: A 52-week multicentre, prospective, observational study. Methods: Outpatients (⩾40 years old) diagnosed with COPD were enrolled from 50 secondary and tertiary hospitals across six geographical regions. Data were collected in routine clinical practice. Results: Between June 2017 and January 2019, 5013 patients were enrolled and 4978 included in the analysis. Mean [standard deviation (SD)] age was 66.2 (8.9) years, 79.5% were male and 90% had moderate-to-very-severe airflow limitation. Annual rates of overall and severe exacerbation were 0.56 and 0.31, respectively. During 1 year, 1536 (30.8%) patients experienced ⩾1 exacerbation and 960 (19.3%) patients had ⩾1 exacerbation requiring hospitalization/emergency visit. Mean (SD) COPD assessment test score was 14.6 (7.6) at baseline and 10.6 (6.8) at follow-up; however, 42–55% of patients had persistent dyspnoea, chest tightness and wheezing at 1 year. The most prescribed treatments were inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA) (36.0%), ICS/LABA + long-acting muscarinic antagonist (LAMA) (17.7%) and LAMA monotherapy (15.3%). Among patients with high exacerbation risk (GOLD Groups C and D), 10.1% and 13.1%, respectively, did not receive any long-acting inhalers; only 53.8% and 63.6% of Group C and D patients with ⩾1 exacerbation during follow-up were prescribed ICS-containing therapy, respectively. Mean (SD) adherence for long-acting inhalers was 59.0% (34.3%). Mean (SD) score for the COPD questionnaire was 6.7 (2.4). Conclusion: These results indicate a high burden of severe exacerbations and symptoms in Chinese outpatients with COPD, and low adherence with treatment guidelines, highlighting the need for more effective management nationwide. Registration: The trial was registered on 20 March 2017 (ClinicalTrials.gov identifier: NCT03131362).
Therapeutic effects of thalidomide on patients with systemic sclerosis-associated interstitial lung disease
Authors: Pan Jie , Dong Fei , Ma Li , Zhao Cheng , Qin Fang , Wen Jing , Wei Wanling , Lei Ling 
Published: June 2023

Objective: To evaluate the clinical efficacy of thalidomide in patients with systemic sclerosis-associated interstitial lung disease. Methods: Ninety-six systemic sclerosis-associated interstitial lung disease patients who received basic glucocorticoid treatment and admitted between 2016 and 2020 were included in this study, including 48 cases in the thalidomide group (combination of thalidomide and cyclophosphamide) and 48 cases in control group (cyclophosphamide monotherapy). Evaluation items included clinical symptoms, modified Rodnan skin score, pulmonary function test, chest high-resolution computed tomography scores, and adverse effects between two groups after 24 weeks of treatment. Results: Remarkable improvements in several aspects were found in the thalidomide group, including modified Rodnan skin score, expiratory dyspnea score, cough visual analog scale score, total ground-glass opacity score, and total interstitial lung disease score. Compared to the control group, improvements in the thalidomide group were found, such as significantly decreased cough visual analog scale score and expectoration; increased number of platelets; improved pulmonary fibrosis ( p  = 0.056), and reduced carbon monoxide diffusing capacity ( p = 0.053). There were no statistically significant differences in the expiratory dyspnea score and predicted forced vital capacity between the two groups. Patients who experienced at least one adverse event in the control group and thalidomide group were 33.3% and 64.6% ( p = 0.002); while those with serious adverse events were 8.3% versus 12.5% ( p = 0.504). Venous thrombosis was found in one case in the thalidomide group. Conclusion: Thalidomide combined with cyclophosphamide can improve the symptoms of cough and expectoration in patients with systemic sclerosis-associated interstitial lung disease, and may slightly delay the progression of pulmonary fibrosis, but with the possibility of an increased risk of adverse events.
The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment
Authors: Fei Ming-Yue , Wang Yong , Chang Bin-He , Xue Kai , Dong Fangyi , Huang Dan , Li Xi-Ya , Li Zi-Juan , Hu Cheng-Long , Liu Ping , Wu Ji-Chuan , Yu Peng-Cheng , Hong Ming-Hua , Chen Shu-Bei , Xu Chun-Hui , Chen Bing-Yi , Jiang Yi-Lun , Liu Na , Zhao Chong , Jin Jia-Cheng , Hou Dan , Chen Xin-Chi , Ren Yi-Yi , Deng Chu-Han , Zhang Jia-Ying , Zong Li-juan , Wang Rou-Jia , Gao Fei-Fei , Liu Hui , Zhang Qun-Ling , Wu Ling-Yun , Yan Jinsong , Shen Shuhong , Chang Chun-Kang , Sun Xiao-Jian , Wang Lan 
Published: June 2023

Abstract
The bone marrow microenvironment (BMM) can regulate leukemia stem cells (LSCs) via secreted factors. Increasing evidence suggests that dissecting the mechanisms by which the BMM maintains LSCs may lead to the development of effective therapies for the eradication of leukemia. Inhibitor of DNA binding 1 (ID1), a key transcriptional regulator in LSCs, previously identified by us, controls cytokine production in the BMM, but the role of ID1 in acute myeloid leukemia (AML) BMM remains obscure. Here, we report that ID1 is highly expressed in the BMM of patients with AML, especially in BM mesenchymal stem cells, and that the high expression of ID1 in the AML BMM is induced by BMP6, secreted from AML cells. Knocking out ID1 in mesenchymal cells significantly suppresses the proliferation of cocultured AML cells. Loss of Id1 in the BMM results in impaired AML progression in AML mouse models. Mechanistically, we found that Id1 deficiency significantly reduces SP1 protein levels in mesenchymal cells cocultured with AML cells. Using ID1-interactome analysis, we found that ID1 interacts with RNF4, an E3 ubiquitin ligase, and causes a decrease in SP1 ubiquitination. Disrupting the ID1-RNF4 interaction via truncation in mesenchymal cells significantly reduces SP1 protein levels and delays AML cell proliferation. We identify that the target of Sp1, Angptl7, is the primary differentially expression protein factor in Id1-deficient BM supernatant fluid to regulate AML progression in mice. Our study highlights the critical role of ID1 in the AML BMM and aids the development of therapeutic strategies for AML.
Galectin-1-dependent ceRNA network in HRMECs revealed its association with retinal neovascularization
Authors: Yang Ning , Zhang Ningzhi , Wang Zhiyi , Cao Wenye , He Xuejun , Zhang Wenxi , Xing Yiqiao 
Published: June 2023

Abstract
Background
Retinal neovascularization (RNV) is a leading cause of blindness worldwide. Long non-coding RNA (lncRNA) and competing endogenous RNA (ceRNA) regulatory networks play vital roles in angiogenesis. The RNA-binding protein galectin-1 (Gal-1) participates in pathological RNV in oxygen-induced retinopathy mouse models. However, the molecular associations between Gal-1 and lncRNAs remain unclear. Herein, we aimed to explore the potential mechanism of action of Gal-1 as an RNA-binding protein.

Results
A comprehensive network of Gal-1, ceRNAs, and neovascularization-related genes was constructed based on transcriptome chip data and bioinformatics analysis of human retinal microvascular endothelial cells (HRMECs). We also conducted functional enrichment and pathway enrichment analyses. Fourteen lncRNAs, twenty-nine miRNAs, and eleven differentially expressed angiogenic genes were included in the Gal-1/ceRNA network. Additionally, the expression of six lncRNAs and eleven differentially expressed angiogenic genes were validated by qPCR in HRMECs with or without siLGALS1. Several hub genes, such as NRIR, ZFPM2-AS1, LINC0121, apelin, claudin-5, and C-X-C motif chemokine ligand 10, were found to potentially interact with Gal-1 via the ceRNA axis. Furthermore, Gal-1 may be involved in regulating biological processes related to chemotaxis, chemokine-mediated signaling, the immune response, and the inflammatory response.

Conclusions
The Gal-1/ceRNA axis identified in this study may play a vital role in RNV. This study provides a foundation for the continued exploration of therapeutic targets and biomarkers associated with RNV.
Comparison between hydroxychloroquine and systemic corticosteroids in IgA nephropathy: a two-year follow-up study
Authors: Si Feng-Lei , Tang Chen , Lv Ji-Cheng , Shi Su-Fang , Zhou Xu-Jie , Liu Li-Jun , Zhang Hong 
Published: June 2023

Abstract
Background
Hydroxychloroquine (HCQ) is recommended as a treatment for IgA nephropathy (IgAN) to control proteinuria. The long-term effects of HCQ compared to systemic corticosteroid therapy remain unclear.

Methods
We conducted a retrospective case‒control study at Peking University First Hospital. Thirty-nine patients with IgAN who received HCQ for at least 24 months without corticosteroids (CSs) or other immunosuppressive agents were included. Thirty-nine matched patients who received systemic CS therapy were selected using propensity score matching. Clinical data over a 24-month period were compared.

Results
In the HCQ group, the level of proteinuria decreased from 1.72 [1.44, 2.35] to 0.97 [0.51, 1.37] g/d (-50.5 [-74.0, -3.4] %, P < 0.001) at 24 months. A significant decline in proteinuria was also found in the CS group, but no significant differences were found between the HCQ group and CS group in the levels of proteinuria (0.97 [0.51, 1.37] vs. 0.53 [0.25, 1.81] g/d, P = 0.707) and change rates (-50.5% [-74.0%, -3.4%] vs. -63.7% [-78.5%, -24.2%], P = 0.385) at 24 months. In addition, the decline rates of eGFR between the HCQ and CS groups were comparable (-7.9% [-16.1%, 5.8%] vs. -6.6% [-14.9%, 5.3%], P = 0.758). More adverse events were observed in the CS group.

Conclusions
Long-term use of HCQ can maintain stable renal function with minimal side effects. In patients who cannot tolerate corticosteroids, HCQ might be an effective and safe supportive therapy for IgAN.
Socio-demographic and environmental determinants of under-five child mortality in Ethiopia: using Ethiopian demographic and Health 2019 survey
Authors: Girma Meseret , Eshete Hiwot , Asrat Rahel , Gebremichael Mignote , Getahun Dereje , Awoke Tadesse 
Published: June 2023

Abstract
Background
The under-five mortality rate is a reliable indicator of a country’s general level of development and the wellbeing of its children. Life expectancy is a good indicator of a population’s standard of living.

Objectives
To identify Socio-demographic and Environmental determinants of under-five child mortality in Ethiopia.

Methods
A national representative cross sectional study and a quantitative study were conducted among 5753 households selected based on 2019 Mini-Ethiopian Demographic and Health Survey (EDHS-2019) data. The analysis was done using STATA version 14 statistical software. Bivariate and multivariate analyses were used. To assess the determinants of under-five child mortality in multivariate analysis, p values less than 0.05 were considered statistically significant, and odds ratios with 95% CI (confidence interval) were used.

Results
A total of 5,753 children were included in the study. Sex of the head of the household being female (AOR = 2:350, 95% CI: 1.310, 4.215), the U5CM for being their mother were currently married (AOR = 2:094, 95% CI: 1.076, 4.072), The odds of U5CM was less by 80% (AOR = 1.797, 95% CI: 1.159–2.782) with the number of under-five children at the household born 2-4th order as compared to those children born on the first order. For the mothers visit anti natal care four and above visit (AOR = 1:803, 95% CI: 1.032, 3.149), for the way of delivery (AOR = 0:478, 95% CI: 0.233, 0.982).

Conclusion
Multivariate logistic analysis reflected that way of delivery, mothers had being currently marred, sex of the head of the household and number of antenatal care visit were found to be significant predictors of under-five child mortality. So, government policy, nongovernmental organizations, and all concerned bodies should be focused on the major determinants of under-five child mortality and put in a lot more effort to reduce under-five child mortality.
The translation and psychometrics Persian version of irrational food belief scale
Authors: Afsahi Fatemeh , Alimehdi Mansoor , Sharif-Nia Hamid 
Published: June 2023

Abstract
Background
This study aimed to translate into the Irrational Food Belief Scale proposed by Osberg into the Persian language and determine the psychometric properties of in Iranian culture.

Methods
Osberg’s 57-item scale was translated into Persian by using the forward-backward method. The scale’s validity was examined using face validity, content validity, and construct validity (exploratory and confirmatory factor analysis). Its reliability was assessed with Cronbach’s alpha and McDonald’s Omega coefficient. Exploratory factor analysis and confirmatory factor analysis was performed by SPSS 28 (500 subjects) and also by AMOS 26 (500 subjects). The participants completed the demographic questionnaire and the Irrational Food Belief Scale (IFBS) over the Internet.

Results
After translation into Persian, the validity of the scale was determined by impact score, quantitative and qualitative face validity (modification of 10 items) and qualitative content validity (modification of 8 items), and quantitative content validity (CVR, CVI and Kappa coefficient), which were greater than 0.46, 0.86, and 0.85, respectively. In exploratory factor analysis, 30 items were removed and the remaining 27 items were loaded on five factors, including behavioral and psychological aspects, nutritional attitudes, healthy eating, controlled eating, and diet, which described 30.95% of the total variance. Confirmatory factor analysis showed that the 5-factor model was the best fitting model to explain the data.

Conclusion
Considering the need for a tool about in irrational food beliefs, this tool was unable to explain all these dimensions well. It is recommended to create a new questionnaire for the Iranian culture.
Efficacy and safety of Kumpe access catheter for pre-percutaneous nephrolithotomy renal access in modified supine percutaneous nephrolithotomy
Authors: Kang Jun-Koo , Lee Sang Hee , Kim Seok-Gi , Kim Ju-Bin , Lee Jeong-Yeon , Ha Seon-Yeon , Ha Chan-Geun , Hong Soon-Ho , Chung Jae-Wook , Ha Yun-Sok , Lee Jun Nyung , Chun So Young , Kim Bum Soo 
Published: June 2023

Abstract
Introduction
Traditionally, a pigtail catheter (PCN) is placed for preoperative renal access before performing percutaneous nephrolithotomy (PCNL). However, PCN can hamper the passage of the guidewire to the ureter, due to which, access tract can be lost. Therefore, Kumpe Access Catheter (KMP) has been proposed for preoperative renal access before PCNL. In this study, we analyzed the efficacy and safety of KMP for surgical outcomes in modified supine PCNL compared to those in PCN.

Materials and methods
From July 2017 to December 2020, 232 patients underwent modified supine PCNL at a single tertiary center, of which 151 patients were enrolled in this study after excluding patients who underwent bilateral surgery, multiple punctures, or combined operations. Enrolled patients were divided into two groups according to the type of pre-PCNL nephrostomy catheter used: PCN versus KMP. A pre-PCNL nephrostomy catheter was selected based on the radiologist’s preference. A single surgeon performed all PCNL procedures. Patient characteristics and surgical outcomes, including stone-free rate, operation time, radiation exposure time (RET), and complications, were compared between the two groups.

Results
Of the 151 patients, 53 underwent PCN placement, and 98 underwent KMP placement for pre-PCNL nephrostomy. Patient baseline characteristics were comparable between the two groups, except for the renal stone type and multiplicity. The operation time, stone-free rate, and complication rate were not significantly different between the two groups; however, RET was significantly shorter in the KMP group.

Conclusion
The surgical outcomes of KMP placement were comparable to those of PCN and showed shorter RET during modified supine PCNL. Based on our results, we recommend KMP placement for pre-PCNL nephrostomy, particularly for reducing RET during supine PCNL.
Evaluation of apical extrusion of debris and centering ability in different nickel-titanium files during curved root canal preparation
Authors: Yu Dongsheng , Guo Li , Gao Jing , Liu Jie , Yang Deqin 
Published: June 2023

AbstractBackgroundCurved root canals lead to difficulties in cleaning, shaping and filling the root canal system. Apical extrusion of debris and root canal transportation are important factors causing postoperative complications. In clinical practice, commonly selected instruments include multifile NiTi systems, such as M3-Pro PLUS (M3-PRO), Orodeka Plex 2.0 (ODP), Rotate (ROT), and Protaper Gold (PTG), as well as single-file NiTi systems, such as M3-L Platinum 2019 (M3L), Waveone Gold (WOG), and Reciproc Blue (RCB). This study aimed to comprehensively evaluate the differences in the apical extrusion of debris and centering ability of the above NiTi files.MethodsSeventy 3D-printed resin teeth were used (n = 10). The apically extruded debris was collected in a preweighed centrifuge tube. The resin teeth with or without root canal preparation were cut into separate cross sections at 1 mm, 3 mm, 5 mm, and 7 mm away from the root apex, and then the root canal transportation and centering ratio of each cross section were calculated.ResultsApical extrusion of debris was highest in RCB but lowest in OD-P (P < 0.05). Root call deviation was lowest in ROT at the 3 mm level, in PTG at the 5 mm level, and in PTG and ROT at the 7 mm level (P < 0.05). The centering ratio of NiTi files was highest in the RCB group at the 3 mm level, in the PTG group at the 5 mm level, in the ROT group at the 7 mm level (P < 0.05).ConclusionsFor NiTi files with the same system, the cross-sectional design is the greatest factor affecting the extrusion of debris, and motion mode is the second. In addition, the multifile system could reduce the degree of root canal transportation.
Cervical cancer screening among English- and Spanish-speaking Hispanic women in an urban safety net health system, 2015–2020
Authors: Amboree Trisha L. , Parker Susan Lackey , Bulsara Shaun , Anderson Matthew L. , Schmeler Kathleen M. , Chiao Elizabeth Y. , Montealegre Jane R. 
Published: June 2023

Abstract
Background
The Hispanic population is heterogeneous with differences in health behaviors across subgroups by nativity and preferred language. We evaluated cervical cancer screening adherence among English- and Spanish-speaking Hispanic patients receiving care at a safety net health system.

Methods
Electronic health records were used to identify 46,094 women aged 30–65. Up to date (UTD) screening was defined based on date of last Pap test, human papillomavirus (HPV) test, or Pap/HPV co-test.

Results
Overall, 81.5% of 31,297 Hispanic women were UTD. English-speaking Hispanic women had a lower prevalence of being UTD when compared to Spanish-speaking Hispanic women (aPR: 0.94, 95% CI: 0.93 – 0.96). Further, those with indigent healthcare plans had a higher prevalence of being UTD when compared to those with private insurance (aPR: 1.10, 95% CI: 1.09 – 1.12), while all other health insurance plans were associated with lower UTD screening when compared to private insurance.

Conclusions
These findings suggest screening differences within the Hispanic population, highlighting the need for disaggregated research assessing heterogeneity within racial/ethnic groups, specifically among Hispanic populations.