bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder
Authors: Thakrar Ashish P. , Uritsky Tanya J. , Christopher Cara , Winston Anna , Ronning Kaitlin , Sigueza Anna Lee , Caputo Anne , McFadden Rachel , Olenik Jennifer M. , Perrone Jeanmarie , Delgado M. Kit , Lowenstein Margaret , Compton Peggy 
Published: February 2023

Abstract
Background
Patients with opioid use disorder (OUD) frequently leave the hospital as patient directed discharges (PDDs) because of untreated withdrawal and pain. Short-acting opioids can complement methadone, buprenorphine, and non-opioid adjuvants for withdrawal and pain, however little evidence exists for this approach. We described the safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with OUD at an academic hospital in Philadelphia, PA.

Methods
From August 2021 to March 2022, a pharmacist guided implementation of a pilot sOAT protocol consisting of escalating doses of oxycodone or oral hydromorphone scheduled every four hours, intravenous hydromorphone as needed, and non-opioid adjuvants for withdrawal and pain. All patients were encouraged to start methadone or buprenorphine treatment for OUD. We abstracted data from the electronic health record into a secure platform. The primary outcome was safety: administration of naloxone, over-sedation, or a fall. Secondary outcomes were PDDs and respective length of stay (LOS), discharges on methadone or buprenorphine, and discharges with naloxone. We compared secondary outcomes to hospitalizations in the 12 months prior to the index hospitalization among the same cohort.

Results
Of the 23 cases, 13 (56.5%) were female, 19 (82.6%) were 40 years or younger, and 22 (95.7%) identified as White. Twenty-one (91.3%) regularly injected opioids and four (17.3%) were enrolled in methadone or buprenorphine prior to hospitalization. sOAT was administered at median doses of 200–320 morphine milligram equivalents per 24-h period. Naloxone administration was documented once in the operating room, over-sedation was documented once after unsanctioned opioid use, and there were no falls. The PDD rate was 44% with median LOS 5 days (compared to PDD rate 69% with median LOS 3 days for prior admissions), 65% of sOAT cases were discharged on buprenorphine or methadone (compared to 33% for prior admissions), and 65% of sOAT cases were discharged with naloxone (compared to 19% for prior admissions).

Conclusions
Pilot implementation of sOAT was safe. Compared to prior admissions in the same cohort, the PDD rate was lower, LOS for PDDs was longer, and more patients were discharged on buprenorphine or methadone and with naloxone, however efficacy for these secondary outcomes remains to be established.
Do geography and institutions affect entrepreneurs’ future business plans? Insights from Greece
Authors: Rasvanis Evangelos , Tselios Vassilis 
Published: February 2023

AbstractIt is widely known that both geography and institutions determine the location of an investment. However, little is known about the impact of these factors on entrepreneurs’ future business plans. Using a questionnaire survey, this paper examines whether the 'first-' and 'second-nature' geography and institutions affect the plans of entrepreneurs to expand or sell their businesses in Greece. The analysis shows that entrepreneurs intend to expand their businesses when the importance of the country's relative geographical location to the international market increases, but that of localisation economies decreases. There is also evidence that entrepreneurs aim to sell their businesses to domestic investors when sea access, the natural environment, the agglomeration economies, the location of Greece and the local governance are ideal for the business performance in the country.
miR-6076 rs1463411 polymorphisms are associated with bleeding during clopidogrel treatment in patients with acute coronary syndrome
Authors: Mo Zhen-Zhen , Yuan Zhen , Peng Yuan-Yuan , Zhou Wan-Lu , Dai Wei , Wang Guo , Tang Jie , Zhang Wei , Chen Bi-Lian 
Published: February 2023

AbstractBleeding is a major adverse event during clopidogrel treatment in patients with acute coronary syndrome (ACS). However, the potential mechanism affecting bleeding among individuals is unclear. Herein, we investigated the involvement of CYP2C19*2 and CYP2C19*3, as well as 10 miRNA polymorphisms, in bleeding in Chinese patients with ACS during the first year of clopidogrel treatment. The miR-6076 rs1463411 G polymorphism was significantly associated with the risk of bleeding (P < 0.001), and the rs1463411 GT + GG genotype significantly increased the risk of bleeding (adjusted odds ratio, 6.09; 95% confidence interval, 1.09–34.0; P < 0.001). Dual luciferase assay showed that miR-6076 significantly decreased the mRNA expression of P2RY12 (P < 0.05). P2RY12 mRNA and protein levels were significantly lower in cells transfected with miR-6076-G than in cells transfected with miR-6076-T (P < 0.05). The findings indicate that miR-6076 targets P2RY12 mRNA and that miR-6076 rs1463411 T/G polymorphisms differentially regulate P2RY12 mRNA and protein levels in cells. rs1463411 G polymorphism may increase the risk of bleeding during clopidogrel treatment in patients with ACS.
Experimental Evaluation of Shape Memory Alloy Retrofitting Effect for Circular Concrete Column Using Ultrasonic Pulse Velocity
Authors: Lee Taemin , Jeong Saebyeok , Woo Ukyong , Choi Hajin , Jung Donghyuk 
Published: February 2023

AbstractThe seismic performance of a concrete column retrofitted with an iron-based shape memory alloy (Fe-SMA) was evaluated under cyclic loading. In addition to structural behavior, internal damage was monitored using an ultrasonic pulse velocity test. The round shapes of three reinforced concrete (RC) columns were tested: a non-retrofitted RC column as a control, a carbon fiber-reinforced polymer (CFRP) column, and an Fe-SMA retrofitted column. During the cyclic loading test, the degradation of the column was defined based on the decrease in compressional wave velocities. The experimental results demonstrated a maximum improvement of 175% in seismic performance of the Fe-SMA retrofitted RC column compared with the controlled column. This is primarily owing to the active constraints of the SMA, which were quantified based on ultrasonic velocities. Furthermore, the surface degradation process was identified using external cracks, which were not visible in the CFRP retrofitted RC column.
Selective footprints and genes relevant to cold adaptation and other phenotypic traits are unscrambled in the genomes of divergently selected chicken breeds
Authors: Romanov Michael N. , Abdelmanova Alexandra S. , Fisinin Vladimir I. , Gladyr Elena A. , Volkova Natalia A. , Koshkina Olga A. , Rodionov Andrey N. , Vetokh Anastasia N. , Gusev Igor V. , Anshakov Dmitry V. , Stanishevskaya Olga I. , Dotsev Arsen V. , Griffin Darren K. , Zinovieva Natalia A. 
Published: February 2023

Abstract
Background
The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by, and formed due to, past and current admixture events. Adaptation to diverse environments, including acclimation to harsh climatic conditions, has also left selection footprints in breed genomes.

Results
Using the Chicken 50K_CobbCons SNP chip, we genotyped four divergently selected breeds: two aboriginal, cold tolerant Ushanka and Orloff Mille Fleur, one egg-type Russian White subjected to artificial selection for cold tolerance, and one meat-type White Cornish. Signals of selective sweeps were determined in the studied breeds using three methods: (1) assessment of runs of homozygosity islands, (2) FST based population differential analysis, and (3) haplotype differentiation analysis. Genomic regions of true selection signatures were identified by two or more methods or in two or more breeds. In these regions, we detected 540 prioritized candidate genes supplemented them with those that occurred in one breed using one statistic and were suggested in other studies. Amongst them, SOX5, ME3, ZNF536, WWP1, RIPK2, OSGIN2, DECR1, TPO, PPARGC1A, BDNF, MSTN, and beta-keratin genes can be especially mentioned as candidates for cold adaptation. Epigenetic factors may be involved in regulating some of these important genes (e.g., TPO and BDNF).

Conclusion
Based on a genome-wide scan, our findings can help dissect the genetic architecture underlying various phenotypic traits in chicken breeds. These include genes representing the sine qua non for adaptation to harsh environments. Cold tolerance in acclimated chicken breeds may be developed following one of few specific gene expression mechanisms or more than one overlapping response known in cold-exposed individuals, and this warrants further investigation.
Functions and mechanisms of lncRNA MALAT1 in cancer chemotherapy resistance
Authors: Hou Junhui , Zhang Gong , Wang Xia , Wang Yuan , Wang Kefeng 
Published: February 2023

AbstractChemotherapy is one of the most important treatments for cancer therapy. However, chemotherapy resistance is a big challenge in cancer treatment. Due to chemotherapy resistance, drugs become less effective or no longer effective at all. In recent years, long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been found to be associated with the development of chemotherapy resistance, suggesting that MALAT1 may be an important target to overcome chemotherapy resistance. In this review, we introduced the main mechanisms of chemotherapy resistance associated with MALAT1, which may provide new approaches for cancer treatment.
Cannabis use amongst tinnitus patients: Consumption patterns and attitudes
Authors: Mavedatnia Dorsa , Levin Marc , Lee Jong Wook , Hamour Amr F. , Dizon Kaye , Le Trung 
Published: February 2023

Background Tinnitus has a significant impact on quality of life and causes considerable psychological distress. Cannabis is known to modulate neuron hyperexcitability, provide protection against auditory damage, and has been used for treatment for many diseases which have physiological similarities with tinnitus. The objective of this study was to survey patients presenting with tinnitus regarding their perspectives and usage patterns of cannabis. Methods Patients with a primary presenting complaint of tinnitus in a tertiary neuro-otology clinic completed a 18-item questionnaire assessing perception, attitudes, and cannabis usage patterns. Results Forty five patients completed the survey (mean age: 54.5 years, 31 females and 14 males). Overall, 96% of patients reported that they would consider cannabis as treatment for their tinnitus. Patients considered cannabis use for auditory symptoms (91%), and symptoms related to their tinnitus, such as emotional complaints (60%), sleep disturbances (64%), and functional disturbances (56%). 36% of patients had previously used cannabis and 22% of patients reported cannabis use at the time of the study. 80% of patients that were actively using cannabis reported that it helped with tinnitus-related symptoms, such as dizziness, anxiety, bodily pain, and sleep disturbances. Most patients would prefer to use edibles (62%), tablet (58%) and cream (47%) formulations of cannabis. Patients were concerned about the cost (29%), potential physical health implications (53%) and psychosocial side effects (60%) of cannabis. Over half of patients learned about cannabis from a friend or family member and only 22% of patients learned about cannabis from a physician or nurse. Conclusion Cannabis use is common amongst patients with tinnitus and current users of cannabis reported that it helped with their symptoms. Most patients would consider its use as a potential treatment to alleviate their tinnitus-related symptoms and are interested in learning more regarding its use. By understanding how cannabis is perceived by tinnitus patients, healthcare providers can provide appropriate patient education. Graphical Abstract
UHPLC‐Q‐TOF‐MS/MS‐guided dereplication to study chemical constituents of Hedera nepalensis leaves in northern Vietnam
Authors: Ngoc Pham Hong , An Tran Chieu , Hiep Nguyen Tuan , Nhu Tran Phan Huynh , Hung Le Ngoc , Trung Nguyen Quang , Minh Bui Quang , Van Trung Phung 
Published: February 2023

AbstractHedera nepalensis is commonly used as a traditional medicine for the treatment of several diseases. In this research, the efficient characterization of chemical constituents, especially triterpenoid saponins, contained in H. nepalensis extract was established by applying ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight tandem mass spectrometry method (UHPLC‐Q‐TOF‐MS/MS). As a result, a total of 45 compounds including 21 triterpene saponins were tentatively elucidated based on MS and MS/MS data, in which eight structures have been reported for the first time. This study provided an efficient analysis strategy to rapidly determine the chemical constituents and laid a foundation for future study of H. nepalensis planted in Northern Vietnam and other Hedera species.
In silico toxicity assessment and trace level quantification of two genotoxic impurities in silodosin using capillary gas chromatography
Authors: Panchakarla Ravi Kiran , Ravi Punna Rao , Buddha Manidhar Syam Kumar , Mullangi Sumanth , Kondapalli Venkata Gowri Chandra Sekhar 
Published: February 2023

AbstractA capillary gas chromatographic method using flame ionization detection was developed and validated for the trace quantification of 2-bromoethanol (2-BE) and 2-bromoethylmethanesulfonate (2-BEM) in silodosin, used in the treatment of benign prostatic hyperplasia. Chromatographic separation was performed in spilt mode using nitrogen as carrier gas on a column containing crosslinked polyethylene glycol (30 m × 0.32 mm, 0.25 µm) stationary phase modified with nitroterephthalic acid. A simple matrix precipitation strategy was implemented to eliminate the sample overload and the matrix interference problems. The developed method was linear and accurate in the concentration range of 24–3000 ppm for 2-BE and 24–300 ppm for 2-BEM with r2 ˃ 0.999 and percent recoveries greater than 90% for both the analytes. The developed method was precise for both the analytes with RSD(%) of not more than 4.5%. In silico genotoxicity and carcinogenicity potential of 2-BEM were assessed using ICH M7 principles. The developed method can be applied in the quality control laboratories of pharmaceutical industries for trace level quantification of 2-BE and 2-BEM in silodosin.
Testing determinations of Thellier paleointensities on 1962 and 1983 lava flows and scoriae in Miyakejima, Japan
Authors: Fukuma Koji 
Published: February 2023

AbstractUsing a fully automated magnetometer, test measurements of paleointensity by the Thellier method were performed on basaltic lava sections, including upper and lower clinkers through the lava interior, and scoriae that erupted from Miyakejima Volcano in 1962 and 1983. Curie temperatures showed a bimodal distribution with titanium-rich and -poor titanomagnetites, and in many cases two phases coexisted in a single sample. Thermomagnetic analyses on all samples prior to the Thellier measurements helped set appropriate temperature steps during Thellier measurements for individual samples. The Thellier results were selected using a combination of TTA and curvature criteria to detect thermal alteration and multidomain effects. Two-thirds of the clinker and scoria samples passed the criteria, which is 4.3 times higher compared to the lava interior. Paleointensities at all six sites are not largely different from the expected geomagnetic field intensities, and the averaged paleointensities for the 1962 and 1983 lavas/scoriae are within 5% of the expected intensities. Pass and fail samples have distinctly different hysteresis properties with a threshold ratio of saturation remanence to saturation magnetization ($$M_{\rm r}/M_{\rm s}$$

M
r

/

M
s

) at 0.22. To obtain reliable Thellier paleointensities on volcanic rocks, rapidly cooled clinkers and scoriae are to be collected, screened for the hysteresis properties, and then heated according to the temperature steps assigned to each sample.
Graphical abstract
Historical regional climate changes in Japan in winter as assessed by a 5-km regional climate model with a land surface process
Authors: Kawase Hiroaki , Fukui Shin , Nosaka Masaya , Watanabe Shun-ichi I. , Otomo Keishi , Murata Akihiko , Murazaki Kazuyo , Nakaegawa Tosiyuki 
Published: February 2023

AbstractWe investigate historical regional climate changes in Japan from 1959 to 2020, analyzing a high-resolution dynamical downscaling forced by the Japanese 55-year Reanalysis (JRA-55). One-year continuous simulations are conducted by the non-hydrostatic regional climate model with a land surface model that includes the snow accumulation process, which enables us to evaluate the seasonal variation of snow cover in all of Japan. Our simulation reproduces interannual variations of the annual mean surface air temperature and annual total precipitation, and it shows rapid warming since around 1980. The annual maximum snow depth and annual maximum daily snowfall show significant decreasing trends at lower elevations on the Japan Sea sides of eastern and western Japan. Areas at higher elevations in eastern Japan show no trend in the maximum snow depth and a significant increasing trend in the maximum daily snowfall. In northern Japan, altitudinal dependencies in snow depth and snowfall changes are smaller on the Japan Sea side than on the Pacific Ocean side: the Japan Sea side shows insignificant changes in snow depth at all elevations, while the Pacific Ocean side shows decreasing and significant increasing trends at lower and higher elevations, respectively. The total number of snow-covered days is decreasing at most elevations in all regions, while the rate of decrease is smaller at higher elevations and latitudes. Composite analyses of annual maximum daily snowfall events at one prefectural city facing the Japan Sea in central Japan indicate that heavy daily snowfall occurs when the Japan Polar air mass Convergence Zone appears over the Japan Sea and the snowfall amounts show increasing and decreasing trends over the mountainous and coastal areas, respectively, due to historical warming and moistening. Our results are basically consistent with previous studies that have focused on future changes in snow depth and snowfall.
A SafeML extension for a unified risk assessment to diverse service robots
Authors: Miyoshi Takao , Nakabo Yoshihiro , Fukui Hidetoshi , Yashiro Makoto , Miyazawa Iko , Sakamoto Takeshi , Ando Noriaki , Kuga Toru , Kitamura Atsushi , Ohara Kenichi , Kimura Tetsuya 
Published: February 2023

AbstractRisk assessment is one of the important processes in the social implementation of robots. In risk assessment and safety design of systems with various stakeholders, modeling and visualization of related elements are important not only for designers but also for users. We examined the use of SafeML in the process and proposed its extension for the purpose for missing elements.
Epidemiology, biology, pathogenesis, clinical manifestations, and diagnosis of dengue virus infection, and its trend in Ethiopia: a comprehensive literature review
Authors: Zerfu Biruk , Kassa Tesfu , Legesse Mengistu 
Published: February 2023

AbstractDengue fever is a dengue virus infection, emerging rapidly and posing public health threat worldwide, primarily in tropical and subtropical countries. Nearly half of the world's population is now at risk of contracting the dengue virus, including new countries with no previous history-like Ethiopia. However, little is known about the epidemiology and impact of the disease in different countries. This is especially true in countries, where cases have recently begun to be reported. This review aims to summarize epidemiology, biology, pathogenesis, clinical manifestations, and diagnosis of dengue virus infection and its trend in Ethiopia. It may help countries, where dengue fever is not yet on the public health list-like Ethiopia to alert healthcare workers to consider the disease for diagnosis and treatment. The review retrieved and incorporated 139 published and organizational reports showing approximately 390 million new infections. About 100 million of these infections develop the clinical features of dengue, and thousands of people die annually from severe dengue fever in 129 countries. It is caused by being bitten by a dengue virus-infected female mosquito, primarilyAedes aegyptiand, lesser,Ae. albopictus. Dengue virus is a member of theFlavivirusgenus of theFlaviviridaefamily and has four independent but antigen-related single-stranded positive-sense RNA virus serotypes. The infection is usually asymptomatic but causes illnesses ranging from mild febrile illness to fatal dengue hemorrhagic fever or shock syndrome. Diagnosis can be by detecting the virus genome using nucleic acids amplification tests or testing NS1 antigen and/or anti-dengue antibodies from serum, plasma, circulating blood cells, or other tissues. Dengue cases and outbreaks have increased in recent decades, with a significant public health impact. Ethiopia has had nearly annual outbreaks since 2013, devastating an already fragmented health system and economy. Standardization of medication, population-level screening for early diagnosis and prompt treatment, and minimization of mosquito bites reduce overall infection and mortality rates.
Clinical application of headache impact test (HIT)-6 and epworth sleepiness scale (ESS) for sleep apnea headache
Authors: Tabata Hiromitsu , Kinoshita Masako , Taniguchi Mitsutaka , Ooi Motoharu 
Published: February 2023

Abstract
Background
Sleep apnea headache is a major symptom accompanying obstructive sleep apnea (OSA), but relatively little evidence has been reported on the magnitude of its negative effects on patients or the evaluation of therapeutic effects. We quantitatively assessed sleep apnea headache using the Epworth sleepiness scale (ESS) and headache impact test (HIT)-6.

Methods
The first part of this study enrolled 86 patients (72 male; mean [± standard deviation] age 53.2 ± 13.8 years) who had been diagnosed with OSA by polysomnography in our sleep center and investigated the prevalence and characteristics of sleep apnea headache. The second part enrolled 21 patients (12 male; mean age, 47.5 ± 13.0 years) diagnosed with sleep apnea headache by polysomnography and/or peripheral arterial tonometry and evaluated the effects of OSA therapy on headache. Medical records including ESS, HIT-6, and polysomnographic data were retrospectively analyzed.

Results
The prevalence of sleep apnea headache among OSA patients was 22.1%, and was higher in female (50.0%) than in male (16.7%). The proportion of N3 and HIT-6 score showed a significant negative correlation (Pearson’s R = -0.51, p < 0.05). In female, median apnea–hypopnea index (AHI) was significantly lower in patients with headache (26.1 /h [interquartile range 21.4–29.6 /h]) than in patients without (54.2 /h [41.3–73.9 /h], p < 0.05, Wilcoxon rank-sum test). HIT-6 and ESS scores improved from 56.4 ± 9.7 to 45.9 ± 8.4 and from 9.0 ± 4.4 to 5.3 ± 4.2 in patients with oral appliance (OA), and from 54.3 ± 10.7 to 44.6 ± 6.1 and from 10.0 ± 4.0 to 4.9 ± 2.9 with continuous positive airway pressure (CPAP). In patients with good CPAP adherence, these scores improved from 58.1 ± 10.8 to 44.0 ± 6.0 and from 9.6 ± 3.8 to 3.6 ± 1.7.

Conclusion
Among patients with OSA, prevalence of sleep apnea headache was higher in female than in male. In female, headache was associated with relatively mild OSA. OA showed substantial effects on headache in mild to moderate OSA patients. CPAP adherence was important for improving the headache. HIT-6 score appears useful for the diagnosis and management of sleep apnea headache.