bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tannic acid-loaded chitosan-RGD-alginate scaffolds for wound healing and skin regeneration
Authors: Mndlovu Hillary , du Toit Lisa C , Kumar Pradeep , Choonara Yahya E 
Published: April 2023

Abstract
Hydrogels have drawn much attention in the field of tissue regeneration and wound healing owing to the application of biocompatible peptides to tailor structural features necessitating optimal tissue remodeling performance. In the current study, polymers and peptide were explored to develop scaffolds for wound healing and skin tissue regeneration. Alginate (Alg), chitosan (CS), and arginine-glycine-aspartate (RGD) were used to fabricate composite scaffolds crosslinked with tannic acid (TA), which also served as a bioactive. The use of RGD transformed the physicochemical and morphological features of the 3D scaffolds and TA crosslinking of the scaffolds improved their mechanical properties, specifically tensile strength, compressive Young’s modulus, yield strength, and ultimate compressive strength. The incorporation of TA as both a crosslinker and a bioactive allowed for 86% encapsulation efficiency and burst release of 57% of TA in 24 h, accompanied by an 8.5% steady release per day of up to 90% over 5 d. The scaffolds increased mouse embryonic fibroblast cell viability over 3 d, progressing from slightly cytotoxic to non-cytotoxic (cell viability >90%). Wound closure and tissue regeneration evaluations in a SpragueDawley rat wound model at predetermined wound healing time points highlighted the superiority of the Alg-RGD-CS and Alg-RGD-CS-TA scaffolds over the commercial comparator product and control. The scaffolds’ superior performance included accelerated tissue remodeling performance from the early to the late stages of wound healing, indicated by the lack of defects and scarring in scaffold-treated tissues. This promising performance supports the design of wound dressings that can act as delivery systems for the treatment of acute and chronic wounds.
Topical effect of polyherbal flowers extract on xanthan gum hydrogel patch—induced wound healing activity in human cell lines and male BALB/c mice
Authors: Saha Ishita , Roy Shubham , Das Deepak , Das Sukhen , Karmakar Parimal 
Published: April 2023

Abstract
Wound or injury is a breakdown in the skin’s protective function as well as damage to the normal tissues. Wound healing is a dynamic and complex phenomenon of replacing injured skin or body tissues. In ancient times the Calendula officinalis and Hibiscus rosa-sinensis flowers were extensively used by the tribal communities as herbal medicine for various complications including wound healing. But loading and delivery of such herbal medicines are challenging because it maintains their molecular structure against temperature, moisture, and other ambient factors. This study has fabricated xanthan gum (XG) hydrogel through a facile process and encapsulated C. officinalis and H. rosa-sinensis flower extract. The resulting hydrogel was characterized by different physical methods like x-ray diffractometer, UV–vis spectroscopy, Fourier transform infrared spectroscopy, SEM, dynamic light scattering, electronkinetic potential in colloidal systems (ZETA) potential, thermogravimetric differential thermal analysis (TGA-DTA), etc. The polyherbal extract was phytochemically screened and observed that flavonoids, alkaloids, terpenoids, tannins, saponins, anthraquinones, glycosides, amino acids, and a few percentages of reducing sugar were present in the polyherbal extract. Polyherbal extract encapsulated XG hydrogel (X@C–H) significantly enhanced the proliferation of fibroblast and keratinocyte cell lines in comparison to the bare excipient treated cells as determined by 3-(4, 5-dimethylthiazol-2-Yl)-2, 5-diphenyltetrazolium bromide assay. Also, the proliferation of these cells was confirmed by BrdU assay and enhanced expression of pAkt. In an in-vivo study, wound healing activity of BALB/c mice was carried out and we observed that X@C–H hydrogel showed significant result compared to the other groups (untreated, X, X@C, X@H). Henceforth, we conclude that this synthesized biocompatible hydrogel could emerge as a promising carrier of more than one herbal excipients.
Potential Fruit and Vegetable Waste as Laundry Liquid Waste Treatment
Authors: Risqi Lucyanita Bayu , Budiastuti M T S , Rosariastuti Retno 
Published: April 2023

Abstract
The laundry industry is one of the largest producers of wastewater and contains high concentrations of chemicals that are not environmentally friendly. Fruit and vegetable waste can be reused through recycling to produce products with higher use and economic value. One of the steps to utilize fruit and vegetable waste is to convert it into eco-enzyme through a simple fermentation technology. This research aims to study the eco-enzyme stability in treating liquid laundry waste. This research is an experiment in a laboratory. The treatments are eco-enzyme raw materials made from fruit oranges waste (E1), vegetables kale waste (E2), and fruits oranges and vegetables kale waste (E3). Then the dilution is carried out with the ratio of eco-enzyme: laundry liquid waste = 1:40. The results showed that: E1 eco-enzyme fruit (orange) can process laundry wastewater phosphate (PO4) of 41.81%, pH of 6.66, BOD of 23.53%, COD of 23.54%, and a TSS of 32.95%. Phosphate (PO4) and pH values have met the quality standards of the Regulation of the Minister of the Environment of the Republic of Indonesia Number 5 of 2014 concerning Wastewater Quality Standards for Business and/or Industrial Activities of Soaps, Detergents, and Vegetable Oil Products.
Recycle Strategy for Processing Waste of the Sanan Tempeh Industrial Centre: Prevention of Air Pollution
Authors: Kalumbang Yuventia Prisca , Saputra Hanley Yunanda , Yulfa Ramadhani Ihsani , Azzahra Keyla , Saputra Arya Yudha 
Published: April 2023

Abstract
The Sanan tempeh industrial center community, located in Malang, East Java, has a special strategy to maintain environmental resilience in the area. 500 SMEs inhabit and produce tempeh in an area of 20 hectares. Each SME processes around 100 kg of soybeans on average into tempeh. In fact, the production of tempeh, of course, produces a lot of waste. The waste generated is boiled water and peeled soybean seeds. Therefore, it can be imagined the environmental burden of supporting the Sanan community from any tempeh production waste that is produced. If they don’t have an adequate waste management strategy, it can pollute the environment in the Sanan area. To anticipate environmental pollution, especially air pollution from boiled soybeans, the residents of Sanan carry out a waste recycling cycle to minimize waste disposal. The research method was carried out through qualitative approaches, such as interviewing the management of community associations as representatives of the Sanan community and observing & documenting several Sanan residents’ homes in managing the waste of Sanan tempeh production. The results of the research show that the waste recycling strategy is manifested in several activities: boiled wastewater and remaining soybean husks have been used as cattle feed, while since 2018 cow dung from the Sanan farm has been used as biogas as energy for burning stoves for tempeh production. The benefit of this strategy is that there is no strong odor generated from the tempeh production process and it strengthens the Sanan’s environmental sustainability.
Sustainability Assessment through Emergy Evaluation Analysis: Agricultural Waste Utilization for Pulp Production Case Study
Authors: Putra Agusta Samodra , Anita Yulia 
Published: April 2023

AbstractThe concern for reducing environmental impacts in pulp and paper industries can be supported with the tools to measure the environmental impacts quantitatively, such as life cycle assessment (LCA) and Emergy Evaluation Analysis (EMA). The sources of potential agricultural wastes for pulp production in Indonesia include oil palm empty fruit bunch (EFB), sugarcane bagasse, bamboo, rice straw, and banana stem. In this study, the first attempt at EFB-based pulp production’s EMA has been done. The main tool for conducting this study was based on EMA and was supported by the LCA framework. The foreground data and model used in this study were based on literature related to pulp production from EFB. In addition, the background data was obtained from the life cycle inventory database. The EMA of EFB-based pulp production was based on emergy yield ratio (EYR), environmental loading ratio (ELR) and emergy sustainability index (ESI). The result shows that EFB-based pulp production has 1.23, 4.43 and 0.28 of EYR, ELR and ESI, respectively.
Assessing Malaysian Firms’ Intention to Use Recombinant Collagen-Like Protein in Collagen Products
Authors: Duasa Jarita , Radzman Nurhasya Adibah Mohd , Thaker Mohamed Asmy Mohd Thas 
Published: April 2023

Abstract
The study aims to assess the prospect of using recombinant collagen-like protein (RCLP) from producers’ point of view. Using cross-sectional data from a survey, the study attempts to validate the proposed hypothesis within Technology Acceptance Model (TAM) by using the Partial Least Square (PLS) path modeling approach (a variance-based SEM technique). Results show a direct positive and significant relations between ‘perceive ease of use’ and ‘attitude toward’, ‘perceived ease of use’ and ‘perceived usefulness’, ‘attitude toward’ and ‘behavioural intention’, and ‘perceived usefulness’ and ‘behavioural intention’ of producing collagen products sourced from recombinant collagen-like protein among firms. The results imply the high potential end collagen products to be marketed using this alternative source of collagen which is environmentally friendly and promotes sustainable development.
Assessment of coastal change detection on an urban coastline: A case study in metropolitan Manila, Philippines
Authors: Limbo-Dizon James Eduard , Dagamac Nikki Heherson A. 
Published: April 2023

Abstract
The coastal zone around the urban coastline of Metro Manila is said to be suffering major environmental difficulties due to fast population growth and urbanization. This study uses remote sensing and GIS techniques to (i) examine changes in land use/land cover and (ii) detect coastal changes. Between 1992 and 2020, four Landsat map images were obtained to create land-use/land-cover (LULC) maps to detect shoreline changes. Each dataset is subjected to an accuracy assessment, with an average LULC mapping accuracy of roughly 90%. The northern part of the study area, which is in Navotas City was composed of trees and grasslands but as the years went by it was converted into fishponds while the critically important Ramsar site, LPPCHEA, have maintained the preservation of its natural mangrove forest. In a 30-year period, the urban coastline of Metro Manila decreased by around 1.5 kilometers. This study can be used to design a long-term plan and environmental management strategy of Metro Manila.
Application of Amendment and Irrigation toward Soil Moisture and Corn Productivity in Alfisols Jumantono, Indonesia
Authors: Ariyanto Dwi Priyo , Syaifudin Ekhsan , Sumani  , Suyana Jaka 
Published: April 2023

Abstract
The use of amendments and irrigation will improve soil characteristics, increase land productivity, and corn crops. This research aims to find out the best type of amendment and irrigation volume to get optimal moisture for corn in Alfisol. The study was conducted at Jumantono, Karanganyar District, Central Java, Indonesia. The design of the study used a Factorial Complete Randomized Block Design (RCBD) with 2 treatment factors. The design of this study on the first treatment factor giving amendments with cow manure 5 tons/ha, biochar rice husk 5 tons/ha, zeolite 5 tons/ha and control, as well as the treatment factor of irrigation volume 50% x ETc, 100% x ETc, and 150% x ETc. The ETc value is obtained from the daily evapotranspiration value of corn. The results show that amendment and irrigation treatment could increase soil moisture content and soil organic matter. The addition of a single factor of irrigation affects the soil porosity, soil pH, soil moisture and soil organic matter. Corn crop productivity has also increased due to the provision of appropriate and efficient irrigation.
The Use of Adaptive Rice Varieties against Lodging in Yogyakarta Irrigated Low Land, Indonesia
Authors: Widyayanti Setyorini , Pustika Arlyna Budi 
Published: April 2023

Abstract
Lodging of some rice fields in irrigated low land of Yogyakarta has been usually occured during wet season, which seem as the impact of climate change. To overcome this problem, Indonesia has been produced many new rice varieties which are adaptive to the abiotic stress such as flooding and lodging condition. On the other side, the use of bio inoculant and chemical seed dressing were suggested to increase rice yield under the abiotic stress. This research was aimed to determine the effect of new rice varieties and bio inoculant as well as chemical seed dressing to the rice growth and yield in Yogyakarta. Research was conducted on the wet season 2021/2022 at irrigated low land of rice agro ecosystem in Yogyakarta, Indonesia. The research trial was designed in randomized block with 2 factors and 4 replications. Factor 1 was variety while factor 2 was bio inoculant and chemical seed dressing usage. Results showed that both variety and bioinoculant or chemical seed dressing gave positive effect to the plant height, numbers of tiller, weight of 100 grains, and root weight. Unfortunately, lodging was occurred at variety Inpari 45 Dirgahayu during the high rain intensity combine with strong wind, resulted non optimal yield obtained. However, bio inoculant of bacterium and fungi consorsia resulted higher yield, while the best yield was obtained from variety Inpari 32 HDB. As conclusion, the use of Inpari 32 HDB and Inpari 48 as new variety was promising to overcome lodging and increase the yield of Yogyakarta rice.
Impact of Bauxite Mining on Soil Chemical Properties at Several Depths
Authors: Sulakhudin  , Sukirno  , Abdilla Andi Massoeang 
Published: April 2023

Abstract
Bauxite is one of the mining commodities that have high economic value as a contributor to the country’s foreign exchange with a potential of 349.61 million tons. The potential for bauxite is large enough to cause soil damage at the beginning of mining because to get bauxite ore, it has to move the layer of soil above it. Soil damaged by the bauxite mining process was improve with reclamation activities, which is one of the PT ANTAM obligations after the extraction of bauxite ore is complete. The soil in the reclamation area after bauxite mining has some very low soil chemical properties, for example the nutrient content of N, K, Ca, Mg and Na. In addition, the cation exchange capacity is very low, each ranging from 2.56 - 5.82 Cmol(+).kg−1, while base saturation is between 6.53 – 12.45%. Soil pH values ranged from 4.32 to 5.11 which was classified as very acidic to acidic. There is a tendency in the deeper soil layers some soil properties to decrease, such as pH, CEC, base saturation and C-organic content.
Soybean Response to Organic Fertilizer Types in Pine Stand-Based Agroforestry System
Authors: Budiastuti M T S , Purnomo D , Pujiasmanto B , Supriyono  , Wahidurromdloni F , Setyaningrum D 
Published: April 2023

AbstractThe agricultural sector currently produces about 18.4% of the total emissions of greenhouse gases that cause climate change. This impact causes a decrease in the quality and quantity of agricultural products such as soybeans. One of the efforts to increase soybean production is by agroforestry systems. This research to examine the response of soybeans to organic fertilizers from various agricultural wastes in a pine-based agroforestry system. The research design used a completely randomized block design with one treatment fertilization with four levels, namely chemical fertilizers;Indigofera tinctoriacompost; corn cobs compost; peanut green manure. The type of organic fertilizer affects plant height, total chlorophyll, plant biomass, number of pods planted, and seed yield per hectare. Peanut green manure showed the highest seed yield per hectare at 1.4887 tons.ha−1. The highest plant height in peanut green manure. Meanwhile, with corncob compost, the highest number of pods planted was 14.60 pods. Total chlorophyll reached 1.912931 cd.m−2in the treatment of corn cobs compost. Chlorophyll a was positively correlated with chlorophyll, while plant fresh weight was positively correlated with seed weight per hectare. Agricultural waste can be used as organic fertilizer supporting soybean growth and yield in pine stands-based agroforestry systems.
Use of a Statistical Adaptive Treatment Strategy Approach for Emulating Randomized Controlled Trials Using Observational Data: The Example of Blood-Pressure Control Strategies for the Prevention of Cardiovascular Events Among Individuals With Hypertension at High Cardiovascular Risk
Authors: Jiao Tianze , Platt Robert W , Douros Antonios , Filion Kristian B 
Published: April 2023

Abstract
Statistical approaches to adaptive treatment strategies (ATS) can be used to mimic the sequential decision-making inherently found in clinical practice. To illustrate the use of a statistical ATS approach, we emulated a target trial of different blood pressure (BP) control plans for the prevention of cardiovascular events among individuals with hypertension at high cardiovascular risk, inspired by the Systolic Blood Pressure Intervention Trial (SPRINT). We included 103,708 patients with hypertension and a “QRISK3” estimated 10-year risk of cardiovascular disease of ≥20% who initiated an antihypertensive drug between 1998 and 2018. Dynamic marginal structural models estimated the comparative effects of treating patients with intensive (target BP: 130/80 mm Hg), standard (140/90 mm Hg), and conservative (150/90 mm Hg) BP control strategies. The adjusted hazard ratios (HRs) for the intensive versus standard strategy were 0.96 (95% confidence interval (CI): 0.92, 1.00) for major adverse cardiovascular events and 0.93 (95% CI: 0.88, 0.97) for death from cardiovascular causes. For the conservative versus standard strategy, they were 1.06 (95% CI: 1.02, 1.10) and 1.08 (95% CI: 1.03, 1.13), respectively. These results are largely compatible with SPRINT. ATS can be used to emulate randomized controlled trials of complex treatment strategies in an observational setting and represents an alternative approach for situations where randomized controlled trials are not feasible.
Interactions of Nonsteroidal Antiinflammatory Drugs and Aspirin and Risk of Cardiovascular Disease in Patients With Osteoarthritis
Authors: Wei Jie , Zeng Chao , Lane Nancy E , Li Xiaoxiao , Lei Guanghua , Zhang Yuqing 
Published: April 2023

Abstract
Nonsteroidal antiinf lammatory drugs (NSAIDs) remain the mainstay of the pharmacologic management for relieving osteoarthritis pain, and low-dose aspirin is often prescribed to osteoarthritis patients who are at high risk of cardiovascular disease (CVD). We conducted cohort studies using data from The Health Improvement Network (THIN) database (2000–2019) to assess whether the relationship of initiation of naproxen or ibuprofen vs. initiation of other NSAIDs (excluding both naproxen and ibuprofen), respectively, to the risk of CVD was modified by coprescription of low-dose aspirin among the participants with osteoarthritis. Among participants without coprescription of aspirin, the risk of CVD was lower in naproxen initiators (10.3/1000 person-years) than in other NSAIDs initiators (13.2/1000 person-years; hazard ratio = 0.71, 95% confidence interval: 0.60, 0.85). Among participants with coprescription of aspirin, however, the risk of CVD was higher among naproxen initiators (36.9/1000 person-years) than that among other NSAIDs initiators (34.8/1000 person-years; hazard ratio = 1.48, 95% confidence interval: 1.12, 1.84). The association was significantly modified by coprescription of aspirin (P &lt; 0.001). Similar findings were observed in the association of initiation of ibuprofen vs. other NSAIDs with the risk of CVD, which was significantly modified by coprescription of aspirin (P &lt; 0.001). These findings suggest that osteoarthritis patients and clinicians should be aware of the potential CVD risk of concurrently taking naproxen or ibuprofen and low-dose aspirin.
Causal Effects of Stochastic PrEP Interventions on HIV Incidence Among Men Who Have Sex With Men
Authors: Sewak Ainesh , Lodi Sara , Li Xiaojuan , Shu Di , Wen Lan , Mayer Kenneth H , Krakower Douglas S , Young Jessica G , Marcus Julia L 
Published: April 2023

Abstract
Antiretroviral preexposure prophylaxis (PrEP) is highly effective in preventing human immunodeficiency virus (HIV) infection, but uptake has been limited and inequitable. Although interventions to increase PrEP uptake are being evaluated in clinical trials among men who have sex with men (MSM), those trials cannot evaluate effects on HIV incidence. Estimates from observational studies of the causal effects of PrEP-uptake interventions on HIV incidence can inform decisions about intervention scale-up. We used longitudinal electronic health record data from HIV-negative MSM accessing care at Fenway Health, a community health center in Boston, Massachusetts, from January 2012 through February 2018, with 2 years of follow-up. We considered stochastic interventions that increased the chance of initiating PrEP in several high-priority subgroups. We estimated the effects of these interventions on population-level HIV incidence using a novel inverse-probability weighted estimator of the generalized g-formula, adjusting for baseline and time-varying confounders. Our results suggest that even modest increases in PrEP initiation in high-priority subgroups of MSM could meaningfully reduce HIV incidence in the overall population of MSM. Interventions tailored to Black and Latino MSM should be prioritized to maximize equity and impact.
Intermittent rivers and ephemeral streams are pivotal corridors for aquatic and terrestrial animals
Authors: Sánchez-Montoya María Mar , Datry Thibault , Ruhi Albert , Carlson Stephanie M , Corti Roland , Tockner Klement 
Published: April 2023

Abstract
Rivers are efficient corridors for aquatic animals, primarily under the assumption of perennial flow. However, the recognition that river drying is a common and widespread phenomenon requires reexamining animal movement through river networks. Intermittent rivers and ephemeral streams have been overlooked when studying animal movement, even though approximately 60% of the global river network dries. In the present article, we extend the current focus of river ecology by integrating the effects of drying on the movement of aquatic and terrestrial animals. Moreover, we introduce a conceptual model that challenges the current bias, which is focused on perennial waterways, by encompassing animal movement across hydrologic phases (nonflowing, flowing, dry, rewetting) and habitats (aquatic, terrestrial). We discuss their corridor function in conservation and restoration planning and identify emerging research questions. We contend that a more comprehensive and inclusive view of animal movement in dry channels will advance ecological understanding of river networks and respective conservation efforts.