bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators for recruiting and retaining male participants into longitudinal health research: a systematic review
Authors: Haritopoulou-Sinanidou Melina , Gabrovska Pam , Tseng Hsu-Wen , Honeyman David , Schweitzer Daniel , Borg Danielle , Rae Kym M. 
Published: August 2023

Abstract
Background
Successfully recruiting male participants to complete a healthcare related study is important for healthcare study completion and to advance our clinical knowledgebase. To date, most research studies have examined the barriers and facilitators of female participants in longitudinal healthcare-related studies. Recruitment of male participants to longitudinal healthcare research studies poses a unique set of challenges. This systematic review examines the unique barriers and facilitators to male recruitment across longitudinal healthcare-related research studies.
Methods
Following PRIMSA guidelines, MEDLINE, Embase, CINAHL and Web of Science databases were systematically searched using the terms recruitment and/or retention, facilitators and/or barriers and longitudinal studies from 1900 to 2021 which contained separate data on males aged 17-59 years. Health studies or interventions were defined longitudinal if they were greater than or equal to 12 weeks in duration with 3 separate data collection visits.
Results
Eighteen articles published from 1976-2021 met the criteria. One-third of the studies had a predominantly male sample and four studies recruited only male participants. Most studies were either of high (39%) or medium quality (39%). Two key themes were identified as being particularly salient to the male population i) patient-related factors (e.g., limited understanding of study rationale as well as the needs for participation in the study) and ii)situational-based factors (e.g., difficulty accessing study sites).
Conclusions
Future research should focus on the specific impact of these factors across the spectrum of longitudinal health-related studies. Based on the findings of this systematic review, researchers from longitudinal health-related clinical trials are encouraged to consider male-specific recruitment strategies to ensure successful recruitment and retention in their studies.
Registration This systemic review is registered with the PROSPERO database (CRD42021254696).
Sedimentary records of sea-level fall at the end-Permian in the upper Yangtze Region, southern China: Implications for the mass extinction
Authors: Duan Xiong , Shi Zhiqiang 
Published: August 2023

Abstract
Sea-level fall is considered one of the significant factors leading to the end-Permian mass extinction. Our study focused on the relative sea-level changes in Beifengjing section which deposited in shallow-water platform and Shangsi section which deposited in deep-water trough. The results indicated a sea-level fall during the Permian—Triassic transition in the Upper Yangtze region. Considering that there is no significant change in fossil abundance in the strata following the two sea-level falls observed in the Beifengjing section, we conclude that the reduction of shallow marine habitat caused by sea level fall alone was insufficient to cause the mass extinction. However, sea-level fall did exacerbate the input of terrestrial debris into the ocean, leading to the deterioration of the marine environment (e.g., soil-induced turbidity and eutrophication). Furthermore, the presence of multiple layers of volcanic tuff near the lithostratigraphic boundary between Permian and Triassic in both sections suggests frequent volcanic activity during sea-level fall. Therefore, we propose that the combined adverse effects of volcanic eruptions, sea-level falls, and other events exceeded the threshold for biological survival, ultimately resulting in the catastrophic end-Permian mass extinction.
Machine Learning Based System for Identification of Light and Heavy Syllables in Sanskrit Verse
Authors: S Hrushikesha Shastry B , Wali Prashant K 
Published: August 2023

Abstract

Prosody provides information regarding a rhythmic structure present in poetry or a verse for any language. In particular, for the Sanskrit language, recognizing the prosody (called “Chandas” in Sanskrit literature) of the verse is entirely dependent on the identification of the light (“Laghu”) and heavy (“Guru”) syllables. In this regard, we propose an efficient and low-complexity two-step machine learning based system for identifying the Laghus and Gurus in Sanskrit verses, by developing an ingenious representation for the syllables. Our novel idea of preparing the first data-set and categorizing the syllables using the first machine learning model enables us to solve the sequence-to-sequence conversion problem as a simple classification problem in the second machine learning model, with two classes namely, the Laghu (denoted by a ‘0’) and the Guru (denoted by a ‘1’). The proposed data representation method and the two-step technique have been found to give an accuracy of more than 99%.
Data recovery methods for DNA storage based on fountain codes
Authors: Schwarz Peter , Freisleben Bernd 
Published: August 2023

Abstract

Today’s digital data storage systems typically offer advanced data recovery solutions. For hard disk drives, various data recovery mechanisms exist, ranging from software-based disk sector or file analysis and data reconstruction techniques up to physical-level data retrieval methods. These approaches support data recovery in the event of catastrophic data loss. In contrast, DNA as a storage medium solely relies on the error correction capabilities of the methods used to encode digital data into strands of DNA. In this work, we present the first approach to provide data recovery for DNA storage. In particular, we present a novel method to reconstruct the original data from corrupted data stored and encoded in DNA using fountain codes. Our method takes advantage of the relationship between processed packets encoded using fountain codes to detect and correct errors. Furthermore, we present content-based and file type specific error detection and correction methods for three file types, to show that knowledge about the encoding can be combined with file-specific redundancy as well as general knowledge about the stored data to successfully reconstruct information from a partially corrupted DNA storage system. We demonstrate the feasibility of our approach by DR4DNA, a software toolkit that includes all of the presented methods, and evaluate DR4DNA using both in-silico and in-vitro experiments.
Letermovir for CMV prophylaxis in very high-risk pediatric hematopoietic stem cell transplantation recipients for inborn errors of immunity.
Authors: César Thibaut , Le Minh Patrick , Klifa Roman , Castelle Martin , Fournier Benjamin , Lévy Romain , Chbihi Marwa , Courteille Virginie , Moshous Despina , Blanche Stéphane , Alligon Mickaël , Leruez-Ville Marianne , Peytavin Gilles , Frange Pierre , Neven Benedicte 
Published: August 2023

Abstract
The burden of CMV infection and disease is important in pediatric hematopoietic stem cell transplantation (HSCT), notably in the subgroup of patients with inborn errors of immunity (IEIs). Letermovir (LMV) is now a standard of care for CMV prophylaxis in adult sero-positive (R+) recipients, but is not yet labeled for children. Published pediatric studies are still scarce. We report a monocentric real-life use of LMV in 36 HSCT pediatric recipients with IEIs considered at high-risk of CMV infection including 14 patients between 2 and 12 months of age. A homogenous dosage proportional to the body surface area was used. Pharmacokinetic (PK) was performed in 8 patients with a median of 6 years of age (range 0,6;15). The cumulative incidence of clinically significant CMV infections (CS-CMVi) and the overall survival of patients under LMV were compared to a very similar historical cohort under (val)aciclovir prophylaxis. LMV tolerance was good. As compared to the historical cohort, the incidence of CS-CMVi was significantly lower in LMV group (5 out of 36 transplants (13.9%) versus 28 of the 62 HSCT (45.2%)) (p = 0.002). Plasma LMV exposures did not significantly differ with those reported in adult patients. In this high-risk pediatric HSCT cohort transplanted for IEIs, CMV prophylaxis with LMV at a homogenous dosage was well tolerated and effective in preventing CS-CMVi compared with a historical cohort.
What makes blood clots break off? A back-of-the-envelope computation to de-mystify blood clot embolization
Authors: Gueltekin Osman , Lohr Matthew , Bechtel Grace , Rausch Manuel 
Published: August 2023

Abstract
One in four deaths worldwide is due to thromboembolic disease; that is, one in four people die from blood clots first forming and then breaking off or embolizing. Once broken off, clots travel downstream, where they occlude vital blood vessels such as those of the brain, heart, or lungs, leading to strokes, heart attacks, or pulmonary embolisms, respectively. Despite clots’ obvious importance, much remains to be understood about clotting and clot embolization. In our work, we set out to untangle the mystery behind clot embolization and try to give a first answer to the simple question: "What makes blood clots break off?" To this end, we conducted experimentally-informed, back-of-the-envelope computations combining fracture mechanics and phase-field modeling. We also focused on deep venous clots as our model problem. Here, we show that of the three general forces that act on venous blood clots -- shear stress, blood pressure and wall stretch-induced interfacial forces -- the latter is a critical embolization force in occlusive and the non-occlusive clot, while blood pressure plays a determinant role only for occlusive clots. Contrary to intuition and prior reports, shear stress, even when severely elevated, is unlikely to cause embolization. This unexpected finding may fundamentally shift both scientists' and practitioners' perspectives on clot embolization and thereby inspire a rethinking of preventative and therapeutic approaches.
The relation between neocortical serotonin 2A receptor binding and neuroticism in the risk for developing depression in healthy individuals: a BrainDrugs study
Authors: Sankar Anjali , Ziersen Simon , Ozenne Brice , Dam Vibeke , Beaman Emily , Kessing Lars , Fisher Patrick , Budtz-Jørgensen Esben , Knudsen Gitte , Miskowiak Kamilla , Frokjaer Vibe 
Published: August 2023

Abstract
The serotonin 2A receptor (5HT2AR) and personality factors indexing stress coping mechanisms are implicated in the pathophysiology of depression. Cross-sectional studies performed in individuals with high familial risk for depression suggest that the coupling between 5-HT2AR and the inward-directed facets of neuroticism may be associated with a risk for depression. This study aimed to build a risk model for first-episode depression in healthy individuals based on serotonergic and personality biomarkers and utilizing up to 19 years of longitudinal data on depression. Such a model could have potential implications for identifying high-risk individuals for early preventative interventions. In this study, 131 healthy volunteers completed an [18F]altanserin positron emission tomography scan to measure 5-HT2AR binding and personality assessment of neuroticism, as part of research studies conducted between 2000-2008. Following study participation, information on future diagnoses of depression was obtained until 2019 from the Danish National Health Registers. Cause-specific Cox regression was used to investigate the hypothesis that neocortical 5-HT2AR binding in interaction with the inward-directed facets of neuroticism (neuroticisminward) would be associated with a risk of developing depression. The study found a significant positive interaction between neocortical 5HT2AR binding and neuroticisminward (p=0.018) such that individuals with high 5-HT2AR binding and high neuroticisminward scores had the highest risk for developing depression. In conclusion, the study provides a novel risk model for first-episode depression. Healthy individuals who have the personality phenotype of high neuroticisminward along with the serotonergic phenotype of high 5-HT2AR binding may be at the greatest risk for developing depression in the future.
High-alert medications errors in a Critical Care Unit
Authors: Pintado-Delgado Maria-Consuelo , Sánchez-Navarro Isabel-María , Baldominos-Utrilla Gemma 
Published: August 2023

Abstract
Purpose To describe the voluntarily reported medications errors related to high-alert medications (HAM) in an adult Intensive Care Unit (ICU).Methods Retrospective observational study. We reviewed all the ICU medications errors related to HAMs reported to intranet-accessible, anonymous adverse event –reporting program by healthcare professionals over 36 months.Results Of the 268 medication errors reported, 102 (38.0%) were related to HAMs. Insulin (19.6%), followed of adrenergic agonist (15.7%), were the most frequent drug class associated with medication error. Prescription errors (54.0%) were the most frequent type of error, mainly related to the use of verbal orders that were not prescribed. Most of the reported medication error (63.7%) did not result in harm to the patient, being the alterations of plasma glucose levels the most frequent harm. All reported damages were transient and resolved with treatment, but all, of them prolonged the stay in ICU.Conclusion Medications errors related to HAMs in UCI are frequent, up to 38% of all the medications errors notified. In our study, most of them were related to insulin and adrenergic agonist. Although in most cases they are not related to permanent damage or death, in 34.3% of them there is an increase in ICU stay.
Single-cell RNA-sequencing analyses along with abundant machine learning methods develop and validate a novel metabolism-related prognostic model in SKCM
Authors: Wang Daiyue , Chen Jiajie , Cao Lu , Luo Sihan , Fang Yuanyuan , Ge Huiyao , Yong Liang , Liu Shengxiu 
Published: August 2023

Abstract
Skin cutaneous melanoma (SKCM) is a fatal form of skin cancer. Metabolic-related genes (MRGs) are a set of genes which can mediate and control all of metabolic related pathways. In this study, the expression levels of MRGs were used to classify all patients into three molecular subtypes. Then the differentially expressed genes (DEGs) among the three MRGs molecular clusters were applied into the LASSO and COX regression analysis to identify five signature genes. Moreover, we constructed a prognostic model for forecasting the prognosis of SKCM and assess the response of the SKCM patients to immunotherapy according to the signature genes. Single-cell RNA-sequencing analyses are used to explore the expression of the five signature genes in immune or non-immune cells. Notably, different expression levels of the signature genes between normal melanocytes and SKCM cells were determined using in vitro experiments including western blot (WB), quantitative PCR (qPCR) and immunohistochemical (IHC) methods. In addition, silencing the expression of SLC5A3 in SKCM cells using small interfering RNAs (siRNAs) would inhibit the proliferation and migration of cells which could be observed by the EdU Fluorescence Labeling, CCK8 and cell transfection methods.
Extrapolation methods for solving hypersingular integral equation of the first kind
Authors: Li Jin 
Published: August 2023

Abstract
The hypersingular integral equation has been studied widely in boundary element methods, especially in natural boundary element methods. The asymptotic expansion of error function of composite rectangle rule for the computation of Hadamard finite-part integrals with the hypersingular kernel 1/ sin 2 (x − s) is obtained. Extrapolation algorithm is constructed. In order to solve the hypersin-gular integral equation, the superconvergence point is taken as the collocation point, then the extrapolation algorithm is presented and the convergence rate of extrapolation algorithm for hypersingular integral equation is presented. At last, some numerical results are also illustrated to confirm the theoretical results and show the efficiency of the algorithms. dt − 4f (s) cot ϵ 2 } (3) The equivalent of (2) and (3) can be similarly obtained in [32]. The composite middle rectangle rule is still valid when the singular point is located at the middle rectangle of each subintervals, in the words, the superconvergence phenomenon of the middle rectangle rule appears at this moment, we obtain the error expansion of the error functional. Moreover, we apply the asymptotic expansion results to construct a algorithm scheme for solving hypersingular integral equations.
MSC Classification: 65D05 65M70.
Study on the critical force range of magnetic compression anastomosis in rabbit intestinal tissue
Authors: Chen Ruomeng , Zhao Guangbin , Fang Ao 
Published: August 2023

Abstract
Purpose
Magnetic compression anastomosis is a new type of anastomosis that can replace traditional manual suture in the reconstruction of digestive tract anastomosis. One of the important prerequisites for the precise mechanical design of the magnamosis device is to obtain the critical compressive stress for ischemic necrosis of the lumen tissue. Although it is difficult to directly observe the deformation and closure of blood vessels in intestinal tissue under magnetic compression, the external manifestation is tissue necrosis. Therefore, the relationship between vascular deformation and crushing stress can be established by studying the necrosis degree of intestinal tissue under stress.
Methods
Magnets with different magnetic force groups (0.3、0.4、0.6、0.7、1.0 and 1.2N ) were implanted into each rabbit to form intestinal tissue side-to-side anastomoses. Three experimental press areas were placed for each rabbit. Thirty-six rabbits were euthanized on each of postoperative day 3, day 5 and day 7. Anastomoses were then harvested and compared with respect to direct observation and histology.
Results
By analyzing the healing state of the tissue in the anastomosis area and the necrosis of the tissue in the anastomotic area, the 0.3N tissue was basically not necrotic, and the 0.4N tissue began to become necrotic, and there was almost no difference between the two specimens at 7 days, and both showed slight healing. Therefore, 0.3N-0.4N is determined as the optimal compressive force range. According to the bottom surface of the magnet device, and the corresponding critical compressive range was 0.88×10− 2 − 1.17×10− 2MPa.
Conclusions
Through magnetic compression anastomosis experiment of intestinal tissue in rabbits, the critical compressive stress range of intestinal tissue was obtained was 0.88×10− 2 − 1.17×10− 2MPa.
A ultra wideband plasmonic reflector based on local resonant bandgap and Bragg bandgap
Authors: Chen San , Fang Liang , Liu Jianqiang , Wu Shan 
Published: August 2023

Abstract
Unlike previous reports that utilized periodic modulation of insulation layer thickness or dielectrics, we propose the use of split ring resonators and their arrays to modulate the propagation characteristics of MIM plasmon waveguides. Due to the strong resonance backscattering of SRR, resonance transmission valleys appear in the transmission spectra of MIM waveguides. Changing the size of SRR can achieve continuously adjustable positions of resonance transmission valleys. The introduction of SRRs periodic arrays will result in two bands (bandgaps) with transmission minimum in the transmission spectra. Combining the dependence of the two bandgaps on the array period and the field distribution, the two bandgaps are Bragg bandgaps and local resonance bandgaps, respectively. By modulating the local resonance bandgap, the Bragg bandgap can be tuned. The introduction of local bandgap increases the degree of freedom to modulate the transmission characteristics of MIM waveguides. Combining local resonant bandgap and Bragg bandgap can significantly increase the reflection bandwidth, achieve broadband filtering, and facilitate the miniaturization of waveguide devices.
Evaluating low impact development of Urban rainwater management at the watershed scale
Authors: Zhang Wei , Meng Yaoyao , Xue Lifang 
Published: August 2023

Abstract
Rapid urbanization has led to ecological problems such as urban stormwater disasters and water pollution, and Low Impact Development (LID) has been proven to be an effective urban stormwater management technique. This study simulated the regulation of runoff volume and pollutants by means of LID stormwater control measures using the Stormwater Management Model (SWMM) in the Sanba River Watershed of Xuzhou City. The results show that after setting up LID measures according to the requirements of sponge city construction in Jiangsu Province and Xuzhou City, surface runoff from the watershed can be adjusted to decrease by about 75% while both infiltration and final storage increase. LID also has a good effect on water purification, with reduction rates of TP and TN of about 35% and 32%, respectively. This study can provide technical support for improving urban rainwater management, deepening the resource utilization of urban rainwater, and building a livable-landscape-ecological city.
Initial non-invasive in vivo sensing of the lung using time domain diffuse optics
Authors: Pifferi Antonio , Miniati Massimo , Farina Andrea , Sekar Sanathana Konugolu Venkata , Lanka Pranav , Mora Alberto Dalla , Maffeis Giulia , Taroni Paola 
Published: August 2023

Abstract

Non-invasive in vivo sensing of the lung with light would help diagnose and monitor pulmonary disorders (caused by e.g., emphysema, immature lung tissue in infants, Covid-19). We investigated the possibility to probe the lung with time domain diffuse optics, taking advantage of the increased depth (few cm) reached by photons detected after a long (few ns) propagation time. An initial study on 5 healthy volunteers included time-resolved broadband diffuse optical spectroscopy measurements at 3 cm source-detector distance over the 600-1100 nm range, and long-distance (7-9 cm) measurements at 820 nm performed during a breathing protocol. The interpretation of the in vivo data with a simplified homogeneous model yielded a maximum probing depth of 2.6-3.9 cm, suitable to reach the lung. Also, signal changes related to the inspiration act were observed, especially at long photon propagation times. Yet, intra- and inter-subject variability and inconsistencies, possibly alluring to competing scattering and absorption effects, prevented a straightforward interpretation. Aspects to be further investigated to gain a deeper insight are discussed.