bluuebunny/crossref_metadata_2025_split huggingface dataset:
Realization of Schmitt Trigger Using Single DXCCII and its Utility as an Adjustable Waveform Generator
Authors: Kumar Atul 
Published: May 2023

This paper presents a Schmitt trigger (ST) circuit with anti-clockwise hysteresis and its utility as an adjustable square/triangular wave generator. The ST circuit employs a single dual-X second-generation current conveyor and two resistors. The threshold voltages of the circuit are adjustable such that it can also function as a zero crossing detector. The circuit has a wide operational frequency range and also consumes low power. Without using an additional active block, a square/triangular wave generator circuit is also realized within the same circuit topology. The generator circuit uses a single active element, one grounded resistor and one grounded capacitor only. The use of grounded passive components makes the proposed generator circuit easily integrable. Additionally, the generator circuit is adjustable as its duty cycle is tunable by means of an external current source. The generator circuit also has a wide operational frequency range from 2.1 Hz to 19.2 MHz. The theoretical aspects of the proposed circuits are validated via Cadence simulations. Additionally, a prototype of DXCCII, which is implemented by using current feedback operational amplifier ICs AD844, is used to verify the ST experimentally.
Factors Affecting the Adoption of Cloud for Software Development: A Case from Turkey
Authors: Pisirir Erhan , Chouseinoglou Oumout , Sevgi Cüneyt , Uçar Erkan 
Published: May 2023

Cloud-based solutions for software development activities have been emerging in the last decade. This study aims to develop a hybrid technology adoption model for cloud use in software development activities. It is based on Technology Acceptance Model (TAM), Technology–Organization–Environment (TOE) framework, and the proposed extension Personal–Organization–Project (POP) structure. The methodology selected is a questionnaire-based survey and data are collected through personally administered questionnaire sessions with developers and managers, resulting in 268 responses regarding 84 software development projects from 30 organizations in Turkey, selected by considering company and project sizes and geographical proximity to allow face-to-face response collection. Structural Equation Modeling (SEM) is used for statistical evaluation and hypothesis testing. The final model was reached upon modifications and it was found to explain the intention to adopt and use the cloud for software development meaningfully. To the best of our knowledge, this is the first study to identify and understand factors that affect the intention of developing software on the cloud. The developed hybrid model was validated to be used in further technology adoption studies. Upon modifying the conceptual model and discovering new relations, a novel model is proposed to draw the relationships between the identified factors and the actual use, intention to use and perceived suitability. Practical and social implications are drawn from the results to help organizations and individuals make decisions on cloud adoption for software development.
The Impact of Germline Alterations in Appendiceal Adenocarcinoma
Authors: Foote Michael B. , Walch Henry , Kemel Yelena , Vakiani Efsevia , Johannet Paul , Sheehan Margaret , Chatila Walid , Chung Sebastian , Nash Garrett M. , Maio Anna , Shia Jinru , Mandelker Diana , Berger Michael , Schultz Nikolaus , Diaz Luis A. , Cercek Andrea , Stadler Zsofia K. 
Published: May 2023

Abstract

Purpose:
More than 10% of assessed patients with appendiceal adenocarcinoma have a pathogenic (P) or likely pathogenic (LP) germline variant, including genes implicated in heritable gastrointestinal cancer syndromes, such as Lynch syndrome. We defined the clinical and molecular impact of heritable alterations in appendiceal adenocarcinoma to evaluate the need for dedicated appendiceal screening and prevention strategies in patients with LP/P germline variants.

Experimental Design:
We performed an integrated germline and somatic molecular analysis for patients with confirmed appendiceal adenocarcinoma. Patients underwent paired tumor-normal sequencing for up to 90 hereditary cancer risk genes and 505 genes for somatic mutation profiling. We defined the cooccurrence of LP/P germline variants and second-hit pathogenic somatic alterations. The associations between germline variants and patient clinicopathologic features were also evaluated.

Results:
Twenty-five of 237 patients (10.5%) carried pathogenic or likely pathogenic germline variants in cancer susceptibility genes. Clinicopathologic characteristics and appendiceal adenocarcinoma–specific survival were similar in patients with or without germline variants. Most (92%, N = 23/25) patients with germline variants demonstrated no second-hit somatic alterations, including loss of heterozygosity. Two patients with a germline APC I1307K low-penetrance founder variant exhibited secondary somatic pathogenic alterations in APC. However, only one patient tumor exhibited APC-mediated WNT signaling dysregulation: a plausible consequence of multiple somatic APC mutations with no germline variant contribution. Four patients had germline variants in PMS2 or MSH2 associated with Lynch syndrome, yet their cancers were microsatellite-stable.

Conclusions:
Germline variants are likely incidental without a contributory driver role in appendiceal adenocarcinoma. Appendiceal adenocarcinoma screening in patients with germline variants is not clearly merited.
La sombra del Condor: breve panorama de Arqueología de la represión y la resistencia en America del Sur
Authors: Zarankin Andrés , López Mazz Jose Maria , Maguire Pedro Pablo Fermin 
Published: May 2023

En el marco de la “guerra fría”, durante la segunda mitad del siglo XX, América Latina se vio inmersa en una serie de golpes militares y actuaciones conjuntas de ejércitos estimulados por las políticas anticomunistas de los EEUU. Estas dictaduras dejaron herencias nefastas de todo tipo, y con las cuales nuestras frágiles democracias continúan teniendo que enfrentar, aun después de pasadas décadas desde su caída. En este contexto, la arqueología viene mostrado su potencial para ayudar a comprender los crímenes cometidos, recuperar los restos de los desaparecidos y reflexionar sobre las políticas de la memoria. En este trabajo señalamos algunas de las direcciones fundamentales de los trabajos arqueológicos sobre la dictadura, sus principales contribuciones y las posibles direcciones para el futuro.
Hierarchical organization of spontaneous co-fluctuations in densely sampled individuals using fMRI
Authors: Betzel Richard F. , Cutts Sarah A. , Tanner Jacob , Greenwell Sarah A. , Varley Thomas , Faskowitz Joshua , Sporns Olaf 
Published: May 2023

Abstract
Edge time series decompose functional connectivity into its framewise contributions. Previous studies have focused on characterizing the properties of high-amplitude frames (time points when the global co-fluctuation amplitude takes on its largest value), including their cluster structure. Less is known about middle- and low-amplitude co-fluctuations (peaks in co-fluctuation time series but of lower amplitude). Here, we directly address those questions, using data from two dense-sampling studies: the MyConnectome project and Midnight Scan Club. We develop a hierarchical clustering algorithm to group peak co-fluctuations of all magnitudes into nested and multiscale clusters based on their pairwise concordance. At a coarse scale, we find evidence of three large clusters that, collectively, engage virtually all canonical brain systems. At finer scales, however, each cluster is dissolved, giving way to increasingly refined patterns of co-fluctuations involving specific sets of brain systems. We also find an increase in global co-fluctuation magnitude with hierarchical scale. Finally, we comment on the amount of data needed to estimate co-fluctuation pattern clusters and implications for brain-behavior studies. Collectively, the findings reported here fill several gaps in current knowledge concerning the heterogeneity and richness of co-fluctuation patterns as estimated with edge time series while providing some practical guidance for future studies.
Rethinking Historical Aspects
Authors: Imaz-Sheinbaum Mariana 
Published: May 2023

Abstract
Explaining the persistence of multiple interpretations of the same historical event has been an ongoing question in the philosophy of history. In this paper I illustrate two possible answers and argue that neither offers a satisfactory resolution. First of all, the realist view, which holds a metaphysical commitment to the past that precludes it from fully recognizing the legitimacy of variability of historical interpretations. Second, Ankersmit’s representationalism which seeks to overcome the realist view by introducing the notion of aspects. Nevertheless, I contend that this latter position ultimately proves indistinguishable from the sort of realist commitments it claims to avoid. In order to overcome these views, I argue that a new conception of historical aspects is needed. By developing a Wittgensteinian notion of aspect seeing, I provide a novel account of historical explanation. Wittgenstein’s insights allow us not only to explain the multiplicity of historical accounts but also to recognize the epistemic activity that goes into historiographical construction.
Impact of North Indian Atmospheric Diabatic Heating on Summer Precipitation in Central Asia
Authors: Wei Yun , Yu Haipeng , Li Shuanglin , Zhu Zhiwei , Yang Yaoxian , Ren Yu , Liu Chenxi , Zhou Jie 
Published: May 2023

Abstract
The impact of North Indian atmospheric diabatic heating variation on summer rainfall over Central Asia (CA) at an interannual scale during 1960–2019 was investigated from thermal adaptation and water vapor transportation perspective. The results showed that more precipitation in southeastern CA is associated with the southward subtropical westerly jet (SWJ), caused by the ascending motion and weakened water vapor output on the south side. When the SWJ moves southward, the high-level water vapor transportation on the south side changes from outward (−1.9 × 106 kg s−1) to inward (0.6 × 106 kg s−1), and the positive anomalous relative vorticity advections by the basic westerly winds produce ascending anomalies over southeastern CA. The position change in the SWJ was mainly related to atmospheric diabatic heating over northern India (NI). The thermal vorticity adaptation caused by a weakened heating rate over NI leads to an anomalous upper-level cyclone over southeastern CA, and the associated cold temperature advection eventually cools the upper troposphere of southeastern CA and reduces the temperature gradient at mid-to-high latitudes, leading to the southward SWJ. Thermal adaptation of the circulation and temperature anomaly over southeastern CA to the NI thermal forcing were also verified by numerical experiments. Both the abnormal ascending motions and the weakened outward water vapor associated with the southward SWJ, caused by the weakened heating rate over NI, lead to more summer rainfall in southeastern CA. The changes in diabatic heating over NI are closely related to Indian Ocean SST. When the Indian Ocean SST is warmer, the south Asian summer monsoon weakens, causing less precipitation and, thus, a weakened heating rate over NI.

Significance Statement
This study established that the northern Indian atmospheric diabatic heating anomalies associated with Indian Ocean SST variation play an important role in influencing precipitation in central Asia (CA). The weakening of the atmospheric diabatic heating over the NI would not only cause an abnormal cyclone and cooling over southern CA through thermal adaptation but also lead to southward subtropical westerly jet (SWJ), ascending motions, and decreased outward water vapor on the south side in southeastern CA, eventually resulting in more precipitation in southeastern CA. The results emphasize the influence of tropical SST and atmospheric heat sources on midlatitude climate and are important for understanding summer precipitation change in southeastern CA.
Comparative Analysis of the Hearing Effects of Partial Ossicular Replacement Prosthesis Versus Conchal Cartilage in Canal Wall Down Mastoidectomy with Type II Tympanoplasty: A Retrospective Case Review Study
Authors: Lu Fei , Zhu Qingwen , Fan Bei , Zhang Yukai , Zhou Min , Zha Dingjun , Chen Yang 
Published: May 2023

Objectives To investigate the effects of titanium partial ossicular replacement prosthesis (PORP) and conchal cartilage for ossiculoplasty on hearing results in single-stage canal wall down (CWD) mastoidectomy surgery with type II tympanoplasty in patients with cholesteatoma. Methods The patients were performed surgeries for the first time by a senior otosurgeon from 2009 to 2022 and were performed CWD mastoidectomy with type II tympanoplasty in one stage were enrolled. Patients who could not be followed up were excluded. Titanium PORP or conchal cartilage was used for ossiculoplasty. When the stapes head was intact, a cartilage 1.2–1.5 mm thick was attached directly to the stapes; when the head of the stapes was eroded, a 1 mm high PORP and cartilage of .2–.5 mm thick were placed on the stapes simultaneously. Results 148 patients were included in the study in total. The titanium PORP and conchal cartilage groups showed no statistically significant differences at 500, 1000, 2000, and 4000 Hz considering the number of decibels of closure of the air-bone gap (ABG) ( P > .05) and pure-tone average ABG (PTA-ABG) ( P > .05). Meanwhile, the closure of PTA-ABG between the 2 groups showed no statistically significant differences in the overall distribution ( P > .05). Conclusions For patients with cholesteatoma and mobile stapes who underwent CWD mastoidectomy with type II tympanoplasty in one stage, either PORP or conchal cartilage is a satisfactory material for ossiculoplasty.
The Strong Correlation Between Pain Interference and Abnormal Nutritional Status in Older Adults With Chronic Musculoskeletal Pain
Authors: Komolsuradej Narucha , Srikrajang Siwaluk , Rangsiprakarn Norrapat , Wongaree Arya , Wasusathapon Chonnapat , Kanjanakomut Darat , Nukaew Vannarat , Cheutalay Wannasak , Kaewpipat Suppawit , Hoonthong Sirinkit , Ung Sochealing , Iamthanaporn Khanin 
Published: May 2023

Objectives: Musculoskeletal pain, one of the most common issues faced by older adults, has multidimensional effects including an increased risk of malnutrition. Therefore, this study aimed to investigate the association between pain interference and nutritional status in older adults with chronic musculoskeletal pain. Methods: In this cross-sectional study, data were collected from older adults (age: >60 years) using the brief pain inventory and mini nutritional assessment questionnaire. The correlation between pain interference, pain severity, and nutritional status was assessed using the chi-square test and Spearman’s rank correlation. Multiple logistic regression analysis was used to analyze the variables associated with abnormal nutrition status. Results: Overall 241 older adults were recruited in the study. The median (IQR) age of the participants was 70 (11) years, pain severity subscale was 4.2 (1.8), and pain interference subscale was 3.3 (3.1). Abnormal nutritional status was positively correlated with pain interference (Odds ratio [OR]: 1.26; 95% confidence interval [CI]: 1.08-1.48; P = .004), pain severity (OR: 1.25; 95% CI: 1.02-1.53; P = .034), age (OR 1.06; 95% CI: 1.01-1.11, P = .011), and hypertension (OR = 2.17; 95% CI: 1.11-4.26; P = .024). Conclusions: This study reports a strong correlation between pain interference and nutritional status. Therefore, pain interference can be a useful pain assessment tool to indicate risk of abnormal nutritional status in older adults. In addition, related factors, including age, underweight, and hypertension, were associated with a higher risk of malnutrition.
Identification of unique transcriptomic signatures through integrated multispecies comparative analysis and WGCNA in bovine oocyte development
Authors: Zhang Fa-Li , Li Wei-Dong , Zhang Geng , Zhang Min , Liu Zhao-Jun , Zhu Ke-Xin , Liu Qing-Chun , Zhang Shu-Er , Shen Wei , Zhang Xi-Feng 
Published: May 2023

AbstractBackgroundCattle (Bos taurus) are a major large livestock, however, compared with other species, the transcriptional specificity of bovine oocyte development has not been emphasised.ResultsTo reveal the unique transcriptional signatures of bovine oocyte development, we used integrated multispecies comparative analysis and weighted gene co-expression network analysis (WGCNA) to perform bioinformatic analysis of the germinal follicle (GV) and second meiosis (MII) gene expression profile from cattle, sheep, pigs and mice. We found that the expression levels of most genes were down-regulated from GV to MII in all species. Next, the multispecies comparative analysis showed more genes involved in the regulation of cAMP signalling during bovine oocyte development. Moreover, the green module identified by WGCNA was closely related to bovine oocyte development. Finally, integrated multispecies comparative analysis and WGCNA picked up 61 bovine-specific signature genes that participate in metabolic regulation and steroid hormone biosynthesis.ConclusionIn a short, this study provides new insights into the regulation of cattle oocyte development from a cross-species comparison.
Modifications in steroid and triterpenoid metabolism in Calendula officinalis plants and hairy root culture in response to chitosan treatment
Authors: Rogowska Agata , Pączkowski Cezary , Szakiel Anna 
Published: May 2023

Abstract
Background
Chitosan, a deacetylated derivative of chitin, is one of the most preferred biopolymers for use as biostimulants and biofertilizers in organic agriculture and as elicitors to enhance the productivity of plant in vitro cultures. Valued as a non-toxic, biodegradable, and environment-friendly agent, it is widely applied to improve plant growth and yield, the content of bioactive specialized metabolites, and resistance to stress conditions and pathogens. However, the influence of chitosan on the growth-defense trade-off, particularly the interplay between steroid and triterpenoid metabolism, has not been extensively investigated.

Results
In this study, Calendula officinalis pot plants and hairy root cultures exposed to chitosan treatment displayed reduced biomass and altered steroid and triterpenoid metabolism. Biosynthesis and accumulation of free forms of sterols (particularly stigmasterol) were inhibited, while the content of sterol esters increased remarkably. The content of some triterpenoids (mainly free triterpenoid acids) was slightly enhanced; however, the biosynthesis of triterpenoid saponins was negatively affected.

Conclusions
These results indicate that in certain plants, chitosan treatment might not positively influence the growth and metabolite production. Therefore, to avoid unexpected effects, initial studies of the conditions of chitosan treatment are recommended, including the dose and the number of chitosan applications, the type of treatment (e.g., foliar or soil), and the vegetative stage of the treated plants.
Frequencies and reasons for unplanned emergency department return visits by older adults: a cohort study
Authors: van Loon-van Gaalen Merel , Voshol Ilje E. , van der Linden M. Christien , Gussekloo Jacobijn , van der Mast Roos C. 
Published: May 2023

Abstract
Background
As unplanned Emergency Department (ED) return visits (URVs) are associated with adverse health outcomes in older adults, many EDs have initiated post-discharge interventions to reduce URVs. Unfortunately, most interventions fail to reduce URVs, including telephone follow-up after ED discharge, investigated in a recent trial. To understand why these interventions were not effective, we analyzed patient and ED visit characteristics and reasons for URVs within 30 days for patients aged ≥ 70 years.

Methods
Data was used from a randomized controlled trial, investigating whether telephone follow-up after ED discharge reduced URVs compared to a satisfaction survey call. Only observational data from control group patients were used. Patient and index ED visit characteristics were compared between patients with and without URVs. Two independent researchers determined the reasons for URVs and categorized them into: patient-related, illness-related, new complaints and other reasons. Associations were examined between the number of URVs per patient and the categories of reasons for URVs.

Results
Of the 1659 patients, 222 (13.4%) had at least one URV within 30 days. Male sex, ED visit in the 30 days before the index ED visit, triage category “urgent”, longer length of ED stay, urinary tract problems, and dyspnea were associated with URVs. Of the 222 patients with an URV, 31 (14%) returned for patient-related reasons, 95 (43%) for illness-related reasons, 76 (34%) for a new complaint and 20 (9%) for other reasons. URVs of patients who returned ≥ 3 times were mostly illness-related (72%).

Conclusion
As the majority of patients had an URV for illness-related reasons or new complaints, these data fuel the discussion as to whether URVs can or should be prevented.

Trial registration
For this cohort study, we used data from a randomized controlled trial (RCT). This trial was pre-registered in the Netherlands Trial Register with number NTR6815 on the 7th of November 2017.
Challenges and opportunities for improved contact tracing in Ghana: experiences from Coronavirus disease-2019-related contact tracing in the Bono region
Authors: Asare Isaac Tachie , Douglas Mbuyiselo , Kye-Duodu Gideon , Manu Emmanuel 
Published: May 2023

Abstract
Background
In Ghana, contact tracing received heightened attention in the fight against the COVID-19 pandemic during its peak period. Despite the successes achieved, numerous challenges continue to limit the efforts of contact tracing in completely curtailing the effect of the pandemic. Despite these challenges, there are still opportunities that could be harnessed from the COVID-19 contact tracing experience for future eventualities. This study thus identified the challenges and opportunities associated with COVID-19 contact tracing in the Bono Region of Ghana.

Methods
Using a focus group discussion (FGD) approach, an exploratory qualitative design was conducted in six selected districts of the Bono region of Ghana in this study. The purposeful sampling technique was employed to recruit 39 contact tracers who were grouped into six focus groups. A thematic content analysis approach via ATLAS ti version 9.0 software was used to analyse the data and presented under two broad themes.

Results
The discussants reported twelve (12) challenges that hindered effective contact tracing in the Bono region. These include inadequate personal protective equipment, harassment by contacts, politicisation of the discourse around the disease, stigmatization, delays in processing test results, poor remuneration and lack of insurance package, inadequate staffing, difficulty in locating contacts, poor quarantine practices, poor education on COVID-19, language barrier and transportation challenges. Opportunities for improving contact tracing include cooperation, awareness creation, leveraging on knowledge gained in contact tracing, and effective emergency plans for future pandemics.

Conclusion
There is a need for health authorities, particularly in the region, and the state as a whole to address contact tracing-related challenges while simultaneously harnessing the recommended opportunities for improved contact tracing in the future for effective pandemic control.