bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating laboratory acoustic measurements, deep neural networks, and micro-CT imaging for characterizing rock brittle deformation
Authors: Ding Jihui , Clark Anthony C. , Vanorio Tiziana 
Published: May 2023

Brittle deformation is prevalent in both geological processes and engineered structures, so probing its actions is an important task as much for Earth materials and engineered ones. To characterize brittle deformation, acoustic waves are especially useful in revealing deformation processes. To promote the use of acoustic techniques, we present an integrated characterization approach that includes both acoustic data collection and analysis. By customizing a rock sample and acoustic sensor assembly, we incorporate acoustic data acquisition into a core holder system that accommodates relatively small samples (2.54 cm diameter) under triaxial loading. Along with fast and high-resolution acoustic waveform recording, the compact design facilitates convenient collection of high-quality acoustic data. To meet the challenge of efficiently and accurately picking P-wave arrivals for hundreds of thousands of acoustic waveforms, we modified and implemented a deep neural network model from the seismology literature called PhaseNet. After training with an augmented dataset of manually-picked arrivals (a total of around 50,000 waveforms), the modified PhaseNet model achieved more than 88% (96%) picking accuracy within ±1 μs (±2 μs) time residual relative to manual picks. This demonstrates the potential of integrating deep learning techniques into the workflow of acoustic data analysis for rapid and accurate extraction of valuable information from a large acoustic dataset. Finally, we conducted high-resolution micro-computed tomography (micro-CT) to inform and complement acoustic characterization at micron- and centimeter-scales. Microscopic observations validate the spatial development of two macroscopic fractures, and suggest that deformation-induced changes in velocity need to be incorporated for accurately locating microcracking events. Thus, integrating acoustic monitoring, a deep neural network, and micro-CT imaging offers an effective means to understand brittle deformation from micro to centimeter scales.
Advanced monitoring of soil-vegetation co-dynamics reveals the successive controls of snowmelt on soil moisture and on plant seasonal dynamics in a mountainous watershed
Authors: Dafflon Baptiste , Léger Emmanuel , Falco Nicola , Wainwright Haruko M. , Peterson John , Chen Jiancong , Williams Kenneth H. , Hubbard Susan S. 
Published: May 2023

Evaluating the interactions between above- and below-ground processes is important to understand and quantify how ecosystems respond differently to atmospheric forcings and/or perturbations and how this depends on their intrinsic characteristics and heterogeneity. Improving such understanding is particularly needed in snow-impacted mountainous systems where the complexity in water and carbon storage and release arises from strong heterogeneity in meteorological forcing and terrain, vegetation and soil characteristics. This study investigates spatial and temporal interactions between terrain, soil moisture, and plant seasonal dynamics at the intra- and inter-annual scale along a 160 m long mountainous, non-forested hillslope-to-floodplain system in the upper East River Watershed in the upper Colorado River Basin. To this end, repeated UAV-based multi-spectral aerial imaging, ground-based soil electrical resistivity imaging, and soil moisture sensors were used to quantify the interactions between above and below-ground compartments. Results reveal significant soil-plant co-dynamics. The spatial variation and dynamics of soil water content and electrical conductivity, driven by topographic and soil intrinsic characteristics, correspond to distinct plant types, with highest plant productivity in convergent areas. Plant productivity in heavy snow years benefited from more water infiltration as well as a shallow groundwater table depth. In comparison, low snowpack years with an early first bare-ground date, which are linked to an early increase in plant greenness, imply a short period of saturated conditions that leads to lower average and maximum greenness values during the growing season. Overall, these results emphasize the strong impact of snowpack dynamics, and terrain and subsurface characteristics on the heterogeneity in plant type and seasonal dynamics.
The influence of interdisciplinary literacy on learning effects among college students: the mediating effects of online physical education on learning behavior
Authors: Zhang Qi , Chen Shan Ping , Hang Lanping 
Published: May 2023

IntroductionThe development of high-quality physical education curriculums is required in the information age. Interdisciplinary literacy and student learning behavior are two significant factors that affect the quality of teaching and learning. This study explores the relationship between interdisciplinary literacy (IDL) and learning effects (LE) among Chinese college students during the COVID-19 pandemic, as well as the mediating effects of online physical education learning behaviors (OPELB). This research aims to provide a reference for the development of high-quality online physical education.MethodsThe study involved 691 college students from 10 general universities in Shaanxi Province as research subjects. Descriptive statistics, Pearson correlation analysis, multiple regression analysis and Bootstrap testing were used to evaluate the mediating effects.ResultsThere was a significant positive relationship between the three variables of IDL, OPELB, and LE (p &lt; 0.001). Multiple regression analysis found that IDL significantly and positively predicted LE and OPELB (p &lt; 0.001), and OPELB predicted LE (p &lt; 0.001). IDL among college students had a total effect of 0.816 on LE, with OPELB accounting for 22.67% of the mediated effect.DiscussionThis study demonstrates that OPELB has a partial mediating effect on IL and LE, and stable IDL and OPELB improve LE. Therefore, teachers should pay attention to improving students’ IDL while encouraging them to develop better OPELB to achieve satisfactory learning outcomes.
Influence of ovarian reserves on assisted reproductive and perinatal outcomes in patients with endometriosis: a retrospective study
Authors: Liu Shuai , Guo Yaxin , Li Fei , Jin Lei 
Published: May 2023

ObjectiveTo investigate the association between different ovarian reserves and reproductive and adverse perinatal outcomes in patients with endometriosis.DesignRetrospective study.SettingReproductive Medicine Center in a hospital.PatientsPatients surgically diagnosed with endometriosis were divided into three groups according to their ovarian reserve: diminished ovarian reserve (DOR) group (n=66), normal ovarian reserve (NOR) group (n=160), and high ovarian reserve (HOR) group (n=141).Intervention(s)None.Main Outcome MeasuresLive birth rate (LBR), cumulative live birth rate (CLBR), and adverse perinatal outcome for singleton live births.ResultsThere were significantly higher live birth and cumulative live birth rates in endometriosis patients with NOR or HOR than in those with DOR. For adverse perinatal outcomes, patients with NOR or HOR had no significant association with preterm birth, gestational hypertension, placenta previa, fetal malformation, abruptio placentae, macrosomia, or low birth weight, except for a decreased risk of gestational diabetes mellitus.ConclusionOur study revealed that although patients with endometriosis with NOR and HOR had increased reproductive outcomes, patients with endometriosis with DOR had still an acceptable live birth rate and a similar cumulative live birth rate with available oocytes. Moreover, patients with NOR and HOR might not exhibit a decreased risk of abnormal perinatal outcomes, except for gestational diabetes mellitus. Multicenter prospective studies are needed to further clarify the relationship.
Nutritional deficiency in South African adults scheduled for bariatric surgery
Authors: Sadhai Prabash , Coetzee Ankia , Conradie-Smit Marli , Greyling C. J. , van Gruting Rutger , du Toit Inge , Lubbe Jeanne , van de Vyver Mari , Conradie Magda 
Published: May 2023

BackgroundGlobally, there is a rising trend in obesity, known to increase morbidity and mortality. Metabolic surgery and adequate weight loss decrease mortality but may worsen pre-existing nutrient deficiencies. Most data on pre-existing nutritional deficiencies in the population undergoing metabolic surgery is from the developed world, where an extensive micronutrient assessment is achievable. In resource-constrained environments, the cost of a comprehensive micronutrient assessment must be weighed against the prevalence of nutritional deficiencies and the potential harm if one or more nutritional deficiencies are missed.MethodsThis cross-sectional study investigated the prevalence of micronutrient and vitamin deficiencies in participants scheduled to undergo metabolic surgery in Cape Town, South Africa, a low-middle income country. 157 participants were selected and 154 reported on; who underwent a baseline evaluation from 12 July 2017 to 19 July 2020. Laboratory measurements were conducted, including vitamin B12 (Vit B12), 25-hydroxy vitamin D (25(OH)D), folate, parathyroid hormone (PTH), thyroid-stimulating hormone (TSH), thyroxine (T4), ferritin, glycated haemoglobin (HbA1c), magnesium, phosphate, albumin, iron, and calcium.ResultsParticipants were predominantly female, aged 45 years (37-51), with a preoperative BMI of 50.4 kg/m2 (44.6-56.5). A total of 64 individuals had Type 2 diabetes mellitus (T2D), with 28 undiagnosed cases at study entry (18% of study population). 25(OH)D deficiency was most prevalent (57%), followed by iron deficiency (44%), and folate deficiency (18%). Other deficiencies (vitamin B12, calcium, magnesium, phosphate) were rarely encountered and affected ≤1% of participants. Folate and 25(OH)D deficiency were related to obesity classification, with a higher prevalence in participants with a BMI ≥40 kg/m2 (p &lt;0.01).ConclusionA higher prevalence of some micronutrient deficiencies was noted compared with data from similar populations in the developed world. The minimum baseline/preoperative nutrient evaluation in such populations should include 25(OH)D, iron studies, and folate. Additionally, screening for T2D is recommended. Future efforts should seek to collate broader patient data on a national scale and include longitudinal surveillance after surgery. This may provide a more holistic picture of the relationship between obesity, metabolic surgery and micronutrient status inform more appropriate evidence-based care.
Vascular endothelial growth factor levels in diabetic peripheral neuropathy: a systematic review and meta-analysis
Authors: Ding Rui , Zhu Shicong , Zhao Xiaoyan , Yue Rensong 
Published: May 2023

ObjectiveVascular endothelial growth factors (VEGFs, including VEGF-A, VEGF-B, VEGF-C, VEGF-D and PLGF) have important roles in the development and function of the peripheral nervous system. Studies have confirmed that VEGFs, especially VEGF-A (so called VEGF) may be associated with the diabetic peripheral neuropathy (DPN) process. However, different studies have shown inconsistent levels of VEGFs in DPN patients. Therefore, we conducted this meta-analysis to evaluate the relationship between cycling levels of VEGFs and DPN.MethodsThis study searched 7 databases, including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP Database, WanFang Database, and Chinese Biomedical Literature (CBM), to find the target researches. The random effects model was used to calculate the overall effect.Results14 studies with 1983 participants were included, among which 13 studies were about VEGF and 1 was VEGF-B, so only the effects of VEGF were pooled. The result showed that there were obviously increased VEGF levels in DPN patients compared with diabetic patients without DPN (SMD:2.12[1.34, 2.90], p&lt;0.00001) and healthy people (SMD:3.50[2.24, 4.75], p&lt;0.00001). In addition, increased circulating VEGF levels were not associated with an increased risk of DPN (OR:1.02[0.99, 1.05], p&lt;0.00001).ConclusionCompared with healthy people and diabetic patients without DPN, VEGF content in the peripheral blood of DPN patients is increased, but current evidence does not support the correlation between VEGF levels and the risk of DPN. This suggests that VEGF may play a role in the pathogenesis and repairment of DPN.
Diagnostic performance of adult-based ultrasound risk stratification systems in pediatric thyroid nodules: a systematic review and meta-analysis
Authors: Xing Zhichao , Qiu Yuxuan , Zhu Jingqiang , Su Anping , Wu Wenshuang 
Published: May 2023

PurposeUltrasound (US) is the first choice in the detection of thyroid nodules in pediatric and adult patients. The purpose of this study was to evaluate the diagnostic performance of adult-based US risk stratification systems (RSSs) when applied to the pediatric population.MethodsMedline, Embase, and Cochrane Library (CENTRAL) were searched up to 5 March 2023 for studies about the diagnostic performance of adult-based US RSS in pediatric patients. The pooled sensitivity, specificity, positive likelihood ratio (LR), negative LR, and diagnostic odds ratio (DOR) were calculated. The summary receiver operating characteristic (SROC) curves and area under the curve (AUC) were also analyzed.ResultsThe sensitivity was highest in American College of Radiology-Thyroid Imaging Reporting and Data System (ACR-TIRADS) category 4–5 and American Thyroid Association RSS high-intermediate risk (ATA), which was 0.84 [0.79, 0.88] and 0.84 [0.75, 0.90], respectively. The specificity was highest in ACR-TIRADS category 5 and Europe-TIRADS (EU-TIRADS) category 5, which was 0.93 [0.83, 0.97] and 0.93 [0.88, 0.98], respectively. The ACR-TIRADS, ATA, and EU-TIRADS showed moderate diagnostic performance in pediatric thyroid nodule patients. For Korea-TIRADS (K-TRADS) category 5, the summary sensitivity and specificity with a 95% CI were 0.64 [0.40, 0.83] and 0.84 [0.38, 0.99], respectively.ConclusionsIn conclusion, the ACR-TIRADS, ATA, and EU-TIRADS have moderate diagnostic performance in pediatric thyroid nodule patients. The diagnostic efficacy of the K-TIRADS was not as high as expected. However, the diagnostic performance of Kwak-TIRADS was uncertain because of the small sample size and small number of studies included. More studies are needed to evaluate these adult-based RSSs in pediatric patients with thyroid nodules. RSSs specific for pediatric thyroid nodules and thyroid malignancies were necessary.
Spatial distribution of non-point source pollution from total nitrogen and total phosphorous in the African city of Mwanza (Tanzania)
Authors: Zong Yunlong , Chen Sophia Shuang , Kattel Giri Raj , Guo Zheng 
Published: May 2023

Rapid urbanization has caused widespread environmental pollution in Africa, restricting sustainable development programs. Today, non-point source pollution has become a major threat to many African cities. In this study, we have classified urban land use followed by the identification of urban functional areas based on multi-source data. We have then evaluated non-point source pollution based on nitrogen and phosphorus loads at a spatial scale in Mwanza city (Tanzania). We have estimated the spatial distribution of total nitrogen (TN) and total phosphorus (TP) loads at a scale of 1 square kilometer grid. The results show that ① the built-up area of the city was identified as 28.9 km2, accounting for 6.8% of the total area of the city. The area of informal settlements was 56.9 km2, accounting for 13.4% of the total area of the city. About 90.38% of 2.41×105 kg of the total TN load and 87.23% of 4.00×104 kg of the total TP load in the city were derived from the informal settlements alone in 2020. ② The average load intensities of TN and TP in Mwanza city were 6.90 kg·hm-2·yr-1 and 1.14 kg·hm-2·yr-1, respectively. The average TN and TP intensities in Mwanza city were slightly higher than the average TN and TP load intensities in the Lake Victoria basin. However, given the high population density of the Mwanza city area, the average TN and TP intensities were found to be consistent. ③ The TN and TP pollution loads were relatively concentrated in the inner urban area, including the lower reaches of the Mirongo River basin, the eastern side of the Nyamagana Peninsula, and the lakeside area extending north and south from the peninsula, and gradually decreased toward the city’s outskirts. We propose that the identified riparian areas in our study should be prioritized as potentially key construction zones for pollution treatment plant facilities and urban renewal pilot programs for restraining the widespread informal settlements. This study contributes to the development of an innovative urban non-point source pollution control measure, which may be applicable to low-income countries in Africa and elsewhere.
Long-term impact of manuring on soil organic matter quality indicators under field cropping systems
Authors: Yadav Rajendra Kumar , Purakayastha Tapan Jyoti , Kumar Dhiraj , Jha Prakash Kumar , Mahala Deep Mohan , Yadav Dinesh Kumar , Khan M. A. , Singh Surendra , Singh Shikha , Vara Prasad P. V. 
Published: May 2023

Introduction: Soil organic matter (SOM) quality is the major driving force for nutrient cycles impacting the productivity of cropping systems. Identification of sensitive indicators and developing metrics to assess SOM quality is a major challenge under field conditions.Methods: Data from a continuing long-term experiment since 2005 at Modipuram, India, were analyzed with key objectives to 1) observe the long-term effect of vermicompost/crop residues alone or in conjunction with NPK chemical fertilizers on crop yield and quality of SOM, 2) identify and develop SOM quality indicators (SOMQI) by encompassing sensitive indicators, and 3) predict system productivity by using SOMQI under rice (Oryza sativa L.)–potato (Solanum tuberosum L.)–wheat (Triticum aestivum L.) (RPW) and maize (Zea mays L.)–potato–onion (Allium cepa L.) (MPO) cropping systems. The treatments comprised of 100% NPK fertilizer; 100% N from vermicompost (N-VC); 50% NPK from fertilizer + 50% N from VC; 100% NPK from fertilizer + crop residue (CR); 100% N from VC + CR.Results: Results showed that continuous application of 100% N-VC and 100% N-VC+CR for eight years considerably increased the soil’s particulate organic matter carbon (POM-C), light fraction organic matter carbon (LFOM-C), and nitrogen (LFOM-N), dissolved organic carbon (DOC) and nitrogen (DON), as well as the available N (AN), available P (AP) and available S (AS) over control. Principal component analysis (PCA) identified AN, POM-C, LFOM-C: N, and DON in RPW and AN, POM-C, microbial biomass carbon (MBC), and LFOM-C: N in MPO cropping system as sensitive SOM quality indicators for the development of SOMQI. Under the MPO cropping system, results were more pronounced with 100% N-VC and 50% NPK+50% N-VC at 0–15 cm soil depth. Furthermore, at 15–30 cm depth, the effect was more prominent in 100% NPK + CR over other treatments.Discussion: Overall MPO cropping system exhibited better SOMQI than the RPW system. Rice, wheat, and maize yields increased significantly under different fertilizer treatments with organic or inorganic amendments. Substitution of fertilizer N with organic sources showed comparable yields obtained under 100% NPK treatment. Partial substitution of chemical fertilizers either by VC and/or CR enhanced the SOM quality and productivity under both cropping systems. The use of PCA-based SOMQI can be helpful in assessing SOM quality and predicting the productivity of cropping systems.
Ethical and legal challenges in nanomedical innovations: a scoping review
Authors: Wasti Sophia , Lee Il Ho , Kim Sumin , Lee Jae-Hyun , Kim Hannah 
Published: May 2023

Background:Rapid advancements in research and development related to nanomedical technology raise various ethical and legal challenges in areas relevant to disease detection, diagnosis, and treatment. This study aims to outline the existing literature, covering issues associated with emerging nanomedicine and related clinical research, and identify implications for the responsible advancement and integration of nanomedicine and nanomedical technology throughout medical networks in the future.Methods:A scoping review, designed to cover scientific, ethical, and legal literature associated with nanomedical technology, was conducted, generating and analyzing 27 peer-reviewed articles published between 2007–2020.Results:Results indicate that articles referencing ethical and legal issues related to nanomedical technology were concerned with six key areas: 1) harm exposure and potential risks to health, 2) consent to nano-research, 3) privacy, 4) access to nanomedical technology and potential nanomedical therapies, 5) classification of nanomedical products in relation to the research and development of nanomedical technology, and 6) the precautionary principle as it relates to the research and development of nanomedical technology.Conclusion:This review of the literature suggests that few practical solutions are comprehensive enough to allay the ethical and legal concerns surrounding research and development in fields related to nanomedical technology, especially as it continues to evolve and contribute to future innovations in medicine. It is also clearly apparent that a more coordinated approach is required to ensure global standards of practice governing the study and development of nanomedical technology, especially as discussions surrounding the regulation of nanomedical research throughout the literature are mainly confined to systems of governance in the United States.
Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model
Authors: Head Kimberly Z. , Bolatimi Oluwanifemi E. , Gripshover Tyler C. , Tan Min , Li Yan , Audam Timothy N. , Jones Steven P. , Klinge Carolyn M. , Cave Matthew C. , Wahlang Banrida 
Published: May 2023

IntroductionPolychlorinated biphenyls (PCBs) are persistent environmental toxicants that have been implicated in numerous health disorders including liver diseases such as non-alcoholic fatty liver disease (NAFLD). Toxicant-associated NAFLD, also known as toxicant-associated fatty liver disease (TAFLD), consists of a spectrum of disorders ranging from steatosis and steatohepatitis to fibrosis and hepatocellular carcinoma. Previously, our group demonstrated that 12-week exposure to the PCB mixture, Aroclor 1260, exacerbated steatohepatitis in high-fat diet (HFD)-fed mice; however, the longer-term effects of PCBs on TAFLD remain to be elucidated. This study aims to examine the longer-term effects of Aroclor 1260 (&gt;30 weeks) in a diet-induced obesity model to better understand how duration of exposure can impact TAFLD.MethodsMale C57BL/6 mice were exposed to Aroclor 1260 (20 mg/kg) or vehicle control by oral gavage at the beginning of the study period and fed either a low-fat diet (LFD) or HFD throughout the study period.ResultsAroclor 1260 exposure (&gt;30 weeks) led to steatohepatitis only in LFD-fed mice. Several Aroclor 1260 exposed LFD-fed mice also developed hepatocellular carcinoma (25%), which was absent in HFD-fed mice. The LFD+Aroclor1260 group also exhibited decreased hepatic Cyp7a1 expression and increased pro-fibrotic Acta2 expression. In contrast, longer term Aroclor 1260 exposure in conjunction with HFD did not exacerbate steatosis or inflammatory responses beyond those observed with HFD alone. Further, hepatic xenobiotic receptor activation by Aroclor 1260 was absent at 31 weeks post exposure, suggesting PCB redistribution to the adipose and other extra-hepatic tissues with time.DiscussionOverall, the results demonstrated that longer-term PCB exposure worsened TAFLD outcomes independent of HFD feeding and suggests altered energy metabolism as a potential mechanism fueling PCB mediated toxicity without dietary insult. Additional research exploring mechanisms for these longer-term PCB mediated toxicity in TAFLD is warranted.