bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal‐Coordination‐Mediated H‐Aggregates of Cyanine Dyes for Effective Photothermal Therapy
Authors: Lv Fangyuan , Feng Erting , Lv Shibo , Liu Dapeng , Song Fengling 
Published: July 2023

AbstractIntegration of cyanine dyes and metal ions into one nanoplatform via metal‐coordination interactions is an effective strategy to build multimodality phototheranostics. The multifunctionalities of the formed nanoscale metal–organic particles (NMOPs) have been widely explored. However, the effect of metal‐coordination interaction on the aggregation behavior of cyanine dyes is rarely reported. Herein, we reported the H‐aggregation behavior of cyanine dye Cy‐3COOH induced by different metal ions M (Fe2+ or Mn2+). Moreover, the extent of H‐aggregates varied with different metal‐coordination interactions. Upon NIR irradiation, H‐aggregates of Cy‐3COOH remarkably promoted photothermal conversion efficiency. Interestingly, we also find that H‐aggregates of Cy‐3COOH induced by metal ions can generate the reactive oxygen species (ROS) involving singlet oxygen (1O2) and superoxide anion radical (O2−⋅) upon light irradiation. In addition, the ROS efficiency varies depending on the extent of H‐aggregates. Additionally, the photoinduced ROS could disassemble aggregates and decompose cyanine dye Cy‐3COOH, which limits the photothermal capability of Cy‐3COOH/M NPs. Therefore, the photothermal performance of Cy‐3COOH/M NPs could be manipulated by the degree of H‐aggregation. This would provide a new insight to develop efficient phototheranostics NMOPs for cancer treatment.
Silver‐Catalyzed para‐Selective Sulfenyl Group Transfer Reactions of N‐Sulfenylanilides
Authors: Nakamura Itaru , Muranushi Ichiro , Asoh Takato , Terada Masahiro 
Published: July 2023

AbstractSilver‐catalyzed reactions of N‐sulfenylanilides afforded the corresponding p‐sulfenylanilides in good to high yields with good para selectivity. The transformation has a high compatibility of functional groups, such as ester, bromo, and iodo groups. Mechanistic studies indicate that the rearrangement reaction proceeds through intermolecular transfer of the sulfenyl group.
Study on the slurrying mechanism of coal water slurry prepared from coal gasification wastewater
Authors: Li Dedi , Feng Biao , Xu Chenxuan , Chen Cong , Wang Jianbin , Huang Huimin 
Published: July 2023

AbstractThe coal gasification process produces a large amount of wastewater which is seriously polluted and difficult to biochemically treat. The regasification of coal water slurry produced from gasification wastewater meets the requirements of clean and efficient use of energy and the concept of circular economy. In this paper, the slurryability of coal water slurry prepared with gasification wastewater was measured, and the influence mechanism of organic matter, metal ions, and ammonia nitrogen components in coal gasification wastewater on slurryability has been studied. Results show that (a) Coal water slurry can be prepared with gasification wastewater, and the composition of wastewater has a great influence on the slurryability. (b) Phenols and alcohols in wastewater are not conducive to slurryability, while urethane in wastewater is beneficial for slurrying. (c) K+ and Na+ in wastewater have little effect on the slurryablity even in high concentration, while Mg2+ and Ca2+ have basically no effect on the slurryability under the concentration range of coal gasification wastewater. However, Fe3+ has a negative effect and Cu3+ has a positive effect on the slurryability at low concentrations. (d) Ammonia nitrogen can affect the slurryability of coal water slurry by affecting the pH of the solution. NH4OH solution is alkaline, which is conducive to slurrying, while (NH4)2SO4 and NH4Cl solutions are acidic, resulting in poor slurryability of coal water slurry.
C‐Aryl Glycosylation via Interrupted Pummerer Rearrangement†
Authors: Li Jiagen , Jiang Xuefeng 
Published: July 2023

Comprehensive SummaryC‐aryl glycosides are an important kind of carbohydrate derivatives for drug discovery, due to their distinctive attributes of resistance to hydrolysis from enzymes. Herein, C‐aryl glycosylation was established for the synthesis of 2‐sulfur C‐aryl glycals and 1,2‐dihydrobenzofuran‐fused C‐aryl glycosides via interrupted Pummerer process, featured with sulfonium‐tethered [3,3]‐sigmatropic rearrangement between sulfoxide glycals and phenols. This protocol offers a broad substrate scope with diverse glycosyl and phenols. Dapagliflozin, Empagliflozin, and Ipragliflozin analogs were straightforward achieved, respectively.
The Impact of Nanomaterial Morphology on Modulation of Carbohydrate–Protein Interactions
Authors: Ravindra Bhoge Preeti , Chandra Ankita , Kikkeri Raghavendra 
Published: July 2023

AbstractCarbohydrate–protein interactions (CPIs) play a crucial role in the regulation of various physiological and pathological processes within living systems. However, these interactions are typically weak, prompting the development of multivalent probes, including nanoparticles and polymer scaffolds, to enhance the avidity of CPIs. Additionally, the morphologies of glyco‐nanostructures can significantly impact protein binding, bacterial adhesion, cellular internalization, and immune responses. In this review, we have examined the advancements in glyco‐nanostructures of different shapes that modulate CPIs. We specifically emphasize glyco‐nanostructures constructed from small‐molecule amphiphilic carbohydrates, block copolymers, metal‐based nanoparticles, and carbon‐based materials, highlighting their potential applications in glycobiology.
Classification of white blood cells based on modified U‐Net and SVM
Authors: Balasubramanian Kishore , Gayathri Devi K. , Ramya K. 
Published: July 2023

SummaryManual investigation of blood cell count is sometimes erroneous due to interoperability error, fatigue error, requiring expert skill and time consuming too. In particular, investigation of white blood cell (WBC) gains importance in identifying diseases like leukemia, leukopenia, etc. WBC does not possess regular structure because they move throughout the blood stream and hence analyzing WBC and its types for structure and shape is quite challenging. To aid in hematology, this work provides classification of WBC classification based on modified U‐Net and support vector machines (SVM). A modified U‐Net architecture is developed to segment WBC followed by feature extraction and classification by radial basis function‐support vector machine (RBF‐SVM). Experiments indicated that the modified U Net segmentation can detect the WBC nucleus with a dice similarity coefficient of 0.972. The proposed U‐Net‐SVM can recognize WBCs in Raabin‐WBC, LISC, and BCCD datasets with an accuracy of 99.45%, 98.62%, and 98.81%, respectively. Further investigation on leukemia dataset, ALL‐IDB2, revealed an accuracy of 99.42% with 100% sensitivity and specificity. The proposed model can be used to investigate WBCs and hence provide a great support to the hematologists in analyzing the blood smear for various disease identifications.
A game theory‐based approach for the study of inter‐interference in coexisting wireless body area networks
Authors: B.N. Priyanka , R Jayaparvathy 
Published: July 2023

SummaryA wireless body area network (WBAN) enables the continuous monitoring of health conditions including heart rate, temperature, and glucose levels. It is composed of several sensors that are placed on the body. The network's performance is significantly affected by the unpredictable movements of the human body. Due to the varying proximities between them, the existence of several WBANs creates a challenge when mobility is involved. In this fictitious scenario, we consider a park area with both mobile and static WBANs or WBAN‐equipped individuals passing through the park who have varying degrees of mobility. When a mobile WBAN passes a static WBAN and is within a minimum distance of the static WBAN, they pair up and immediately interfere. Inter‐interference caused by WBANs operating in a limited area causes packet loss and performance deterioration. In this work, static WBAN locations are optimised to minimise interference and system inter‐interference problems are addressed by a game theoretic method. This paper formulates a flexible game theoretic framework to study WBAN coexistence using the expected pay‐off function considering a two‐player game. It is observed from the results obtained that the probability of interference caused by fast mobile WBANs is reduced to a maximum of 50% compared with that caused by slow mobile WBANs thereby reducing the need for relocation of static WBANs.
Asymmetric Reductive Amination in Organocatalysis and Biocatalysis
Authors: Li Tingting , Zhou Qian , Meng Fanjing , Cui Wenhui , Li Qian , Zhu Jiang , Cao Yang 
Published: July 2023

AbstractThis review summarizes the recent progress of organocatalytic and biocatalytic asymmetric reductive amination (ARA), a challenging but important topic for drug discovery and the pharmaceutical industry. At present, ARA can be divided into three categories: metal catalysis, organic catalysis, and biocatalysis. In the past decade, transition metal‐catalysed ARA has been well established. Organocatalytic ARA has emerged as a powerful alternative to metal‐catalysed ARA, the hydrogen sources used in organocatalytic ARA are usually Hantzsch esters, benzothiazolines, boranes, and hydrosilanes, which require Lewis base or phosphoric acid catalysts to activate them to give secondary chiral amines. It is worth mentioning that biocatalytic ARA has made remarkable progress in the last decade, amino acid dehydrogenases, amine dehydrogenases, opine dehydrogenases and imine reductases have been successfully used in ARA.
Development of a pseudostatic method for seismic performance evaluation of rocking bridge foundations
Authors: Chiou Jiunn‐Shyang , Lee Tzu‐Chieh , Natalin Maria Desti 
Published: July 2023

AbstractPseudostatic analysis can be an efficient approach to evaluating the dynamic response of structures for a preliminary design. In this paper, we present a pseudostatic method based on a pushover analysis to assess the seismic performance of bridge piers supported by rocking‐governed shallow foundations. The method has two stages. In the first stage, the capacity spectrum method (CSM) is applied to evaluate the maximum acceleration and displacement response of the bridge system. To have an appropriate system damping ratio in the CSM, we propose a method to consider various earthquake energy dissipation mechanisms for the pier and foundation. In the second stage, the footing settlement is evaluated based on the maximum footing rotation; an incrementally cyclic pushover analysis with a fixed footing rotation increment is performed to estimate the footing settlement. Examples are presented to demonstrate the applicability of the proposed method and the results of the proposed method are compared with the dynamic analysis results. Compared with the conventional CSM, the proposed method improves the estimation of system damping and can estimate the settlement after earthquakes.
Performance analysis and comparison of approximate detectors with linear detectors in massive MIMO systems under imperfect channel state information
Authors: Khurshid Kiran , Imran Muhammad , Wakeel Abdul 
Published: July 2023

SummaryMassive MIMO systems are a key technology for enhancing the capacity and reliability of wireless communication systems. However, to unlock the full potential of massive MIMO systems, accurate channel state information is crucial at the receivers. In practice, channel estimation errors are inevitable, leading to significant performance degradation in traditional massive MIMO equalizers that assume perfect channel state information. In this work, we investigate the performance of approximate massive MIMO detectors, specifically the Gauss‐Seidel and Neumann series, over a time‐invariant channel with imperfect channel state information. We derive the expressions of signal‐to‐interference‐plus‐noise ratio and average bit error rate for approximate massive MIMO detectors in a unicellular environment using M‐ary quadrature amplitude modulation. Additionally, we compare the performance of linear detectors, including zero‐forcing, minimum‐mean‐squared‐error, and maximal‐ratio combining, with that of the approximate detectors. Through extensive Monte Carlo numerical simulations and various system configurations, we demonstrate that the Gauss‐Seidel detector, under imperfect channel state information, achieves comparable bit error rate performance to the zero‐forcing and minimum‐mean‐squared‐error detectors while requiring less computational complexity. Our study suggests that the Gauss‐Seidel detector has the potential to be used in massive MIMO systems in the presence of imperfect channel state information, highlighting its practical relevance in real‐world scenarios.
Visual genetic typing of glioma using proximity‐anchored in situ spectral coding amplification
Authors: Chen Xiaolei , Deng Ruijie , Su Dongdong , Ma Xiaochen , Han Xu , Wang Shizheng , Xia Yuqing , Yang Zifu , Gong Ningqiang , Jia Yanwei , Gao Xueyun , Ren Xiaojun 
Published: July 2023

AbstractGliomas are histologically and genetically heterogeneous tumors. However, classical histopathological typing often ignores the high heterogeneity of tumors and thus cannot meet the requirements of precise pathological diagnosis. Here, proximity‐anchored in situ spectral coding amplification (ProxISCA) is proposed for multiplexed imaging of RNA mutations, enabling visual typing of brain gliomas with different pathological grades at the single‐cell and tissue levels. The ligation‐based padlock probe can discriminate one‐nucleotide variations, and the design of proximity primers enables the anchoring of amplicons on target RNA, thus improving localization accuracy. The DNA module‐based spectral coding strategy can dramatically improve the multiplexing capacity for imaging RNA mutations through one‐time labelling, with low cost and simple operation. One‐target‐one‐amplicon amplification confers ProxISCA the ability to quantify RNA mutation copy number with single‐molecule resolution. Based on this approach, it is found that gliomas with higher malignant grades express more genes with high correlation at the cellular and tissue levels and show greater cellular heterogeneity. ProxISCA provides a tool for glioma research and precise diagnosis, which can reveal the relationship between cellular heterogeneity and glioma occurrence or development and assist in pathological prognosis.
Couple stress effects on the MHD oscillatory flow in a fluid‐saturated porous layer
Authors: Raghunatha K. R. , Vinod Y. 
Published: July 2023

AbstractIn this paper, the oscillatory flow of hydromagnetic couple stress fluid‐saturated porous layer with inhomogeneous wall temperatures is studied. The flow is modeled using the modified Darcy equation. The fluid is subjected to a transverse magnetic field and the velocity slip at the lower plate is taken into deliberation. The governing coupled partial differential equations of the flow are transformed to coupled ordinary differential equations and are solved analytically. The impact of the physical parameters such as the Grashof number, Prandtl number, Darcy number, Hartmann number, and couple stress parameters on velocity profiles, temperature, rate of heat transfer, and skin friction are emphasized. The velocity field increased as either the Grashof number, the Darcy number, the suction/injection parameter, and Prandtl number increased nevertheless reverse growth can be seen by increasing the Hartmann number and the couple stress parameter. The temperature field in the channel increases with increasing the suction/injection parameter and Prandtl number but a conflicting development can be seen with increasing the oscillation amplitude. It is interesting to note that skin friction increases on both channel plates as injection increases on the heated plate.
Cryptocurrencies in an uncertain world: Comprehensive insights from a wide range of uncertainty indices
Authors: Hung Ngo Thai , Huynh Toan Luu Duc , Nasir Muhammad Ali 
Published: July 2023

AbstractThis study investigates the impacts of economic policy uncertainty on the Bitcoin market using the monthly data from January 2014 to December 2022. In so doing, six major uncertainty indices (Global Economic Policy Uncertainty, Equity Market Volatility, Twitter‐based Economic Uncertainty, Geopolitical risk index, The Cryptocurrency Policy Uncertainty Index, The Cryptocurrency Price Uncertainty Index), and in particular, two novel Cryptocurrency Uncertainty indexes as introduced by Lucey et al. (2022) are taken into account. Our findings uncover a negative connectedness between Bitcoin prices and the key selected uncertainty indices, suggesting that higher uncertainties result in lower Bitcoin fluctuation across time and frequency domains. Our results provide valuable information on constructing asset portfolios for investors who have investment strategies entailing Bitcoin since Bitcoin would be a diversifier under economic policy uncertainty shocks. Our results hold robust by using the alternative methodology.
Core processing neuron‐enabled circuit motifs for neuromorphic computing
Authors: Li Hanxi , Hu Jiayang , Chen Anzhe , Zhang Yishu , Wang Chenhao , Wang Beiduo , Tong Yi , Zhou Jiachao , Loh Kian Ping , Xu Yang , Hasan Tawfique , Yu Bin 
Published: July 2023

AbstractBased on brain‐inspired computing frameworks, neuromorphic systems implement large‐scale neural networks in hardware. Although rapid advances have been made in the development of artificial neurons and synapses in recent years, further research is beyond these individual components and focuses on neuronal circuit motifs with specialized excitatory–inhibitory (E–I) connectivity patterns. In this study, we demonstrate a core processor that can be used to construct commonly used neuronal circuits. The neuron, featuring an ultracompact physical configuration, integrates a volatile threshold switch with a gate‐modulated two‐dimensional (2D) MoS2 field‐effect channel to process complex E–I spatiotemporal spiking signals. Consequently, basic neuronal circuits are constructed for biorealistic neuromorphic computing. For practical applications, an algorithm‐hardware co‐design is implemented in a gate‐controlled spiking neural network with substantial performance improvement in human speech separation.image
Teen perceptions of adolescent dating violence
Authors: Morrison Katheryn E. , Hymel Shelley , Craig Wendy , Dirks Melanie , Holfeld Brett 
Published: July 2023

AbstractIntroductionPrevious research shows that adolescents who experience dating violence most often disclose their victimization to a peer or friend, more so than to other sources of support. However, surprisingly little research has explored how adolescents respond to peer disclosures of dating violence. Addressing this gap, the present study assessed variations in adolescents' perceptions of blame, interpretations of the incident as violence, and intentions to respond across physical, psychological, sexual, cyber‐psychological, and cyber‐sexual dating violence scenarios.MethodsAs part of a national research project across Canada, 663 high school adolescents (432 girls, 65.2%) between the ages of 14‐17 were randomly assigned to complete a questionnaire which included one of five different hypothetical dating violence scenarios. Next, participants responded to questions about their perceptions of the incident, as well as victim and perpetrator blame and responsibility, and their intentions to respond.ResultsResults indicated that the type of dating violence experienced and the age and gender of participants all played a role in perceptions of blame, understandings of violence, and intentions to respond.ConclusionsAs one of the first studies to explore how adolescents perceived and responded to dating violence, considering both in‐person and cyber forms of dating violence, this study fills an important gap in the literature. Findings underscore the uniqueness of cyber forms of dating violence and how pre/intervention programs must address the specific contexts and issues unique to each type of dating violence.
Analysis for codon usage bias in membrane anchor of nonstructural protein 5A from BVDV
Authors: Gao Mingyang , Yang Xuanye , Wu Yuhu , Wang Jinqian , Hu Xinyan , Ma Zhongren , Zhou Jian‐hua 
Published: July 2023

AbstractThe nonstructural protein 5A (NS5A) of the bovine viral diarrhea virus (BVDV) is a monotopic membrane protein. This protein can anchor to the cell membrane by an in‐plane amphipathic ⍺‐helix, which participates in the viral replication complex. In this study, the effects of synonymous codon usage pattern of NS5A and the overall transfer RNA (tRNA) abundance in cells on the formation of the in‐plane membrane anchor of NS5A were analyzed, based on NS5A coding sequences of different BVDV genotypes. BVDV NS5A coding sequences represent the most potential for BVDV genotyping. Moreover, the nucleotide usage of BVDV NS5A dominates the genotype‐specific pattern of synonymous codon usage. There is an obvious relationship between synonymous codon usage bias and the spatial conformation of the in‐plane membrane anchor. Furthermore, the overall tRNA abundance profiling displays that codon positions with a high level of tRNA abundance are more than ones with a low level of tRNA abundance in the in‐plane membrane anchor, implying that high translation speed probably acts on the spatial conformation of in‐plane membrane anchor of BVDV NS5A. These results give a new opinion on the effect of codon usage bias in the formation of the in‐plane membrane anchor of BVDV NS5A.
Increasing Pedicle Reach with Musculocutaneous Perforator Dissection in Anterolateral Thigh Free Flaps
Authors: Plonowska‐Hirschfeld Karolina A. , House Adrian , Park Andrea M. , Seth Rahul , Heaton Chase M. , Fridirici Zachary , Knott P. Daniel 
Published: July 2023

ObjectiveTo measure the increase in effective pedicle reach with microdissection of musculocutaneous perforators during anterolateral thigh (ALT) free tissue harvest.MethodsA review of our institution's free flap database was performed to identify ALT free tissue transfers. The distance from pedicle vessel origin to its perforator's insertion at the fascia lata (effective pedicle length [EPL]) was measured prior to and following intramuscular dissection of musculocutaneous perforators. Pertinent clinicopathologic variables were abstracted from the electronic medical record.ResultsA total of 314 ALT free flaps were performed between February 2017 and August 2022. Of these, 85 had documentation of EPL before and after musculocutaneous perforator dissection. ALT reconstruction was primarily performed for reconstruction of oncologic ablative defects (66, 78%). The mean EPL prior to perforator microdissection was 8.8 cm (standard deviation, SD 2.8 cm; range 3–15 cm). Following perforator dissection, mean EPL significantly increased to 14.0 cm (SD 3.0 cm; range 7–22 cm) with a mean net gain of 5.2 cm in distance (95% confidence interval 4.8–5.6 cm; p < 0.001). Nine patients (11%) required operating room take‐back for anastomosis revision (3, 3.5%), recipient site hematoma evacuation (4, 4.7%), and wound dehiscence (2, 2.3%); one complete flap loss due to venous thrombosis was observed.ConclusionDissection of musculocutaneous perforators during ALT free flap harvest can increase effective pedicle reach by 5.2 cm or nearly 60%. This harvest technique can facilitate the performance of tension‐free anastomoses when substantial vascular pedicle length or vascular pedicle tunneling is required.Level of Evidence4 Laryngoscope, 134:666–670, 2024