bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness and safety of laparoscopic uterosacral ligament suspension: A systematic review and meta‐analysis
Authors: Vermeulen Carolien K. M. , Schuurman Britt , Coolen Anne‐Lotte W. M. , Meijs‐Hermanns Puck R. , van Leijsen Sanne A. L. , Veen Joggem , Bongers Marlies Y. 
Published: June 2023

AbstractBackgroundLaparoscopic uterosacral ligament suspension (LUSLS) is a technique to correct apical pelvic organ prolapse (POP) by shortening the uterosacral ligaments with sutures.ObjectiveA systematic review with meta‐analysis of the effectiveness and safety of LUSLS as treatment for apical POP.Search strategyPubMed and Cochrane search using ‘pelvic organ prolapse’, ‘laparoscopy’ and ‘uterosacral’, including synonyms.Selection criteriaAll articles in English presenting outcome of an original series of women with LUSLS as treatment of apical POP. Case reports were excluded.Data collection and analysisStudy enrollment was performed by two reviewers. Our primary outcome measures were objective and subjective effectiveness of the procedure. Secondary outcome measures regarded complications and recurrence. Bias was assessed with the Newcastle Ottawa Scale.Main resultsOf 138 hits, 13 studies were included with 933 LUSLS patients. The average follow‐up was 22 months. All were nonrandomised cohort studies. The pooled anatomic success rate is 90% for all LUSLS procedures (95% confidence interval [CI] 83.3–95.5). LUSLS with hysterectomy resulted in an anatomic success rate of 96.6% (95% CI 87.5–100) and LUSLS with uterus preservation 83.4% (95% CI 67.7–94.6). The pooled subjective cure rate was 90.5% (95% CI 81.9–96.5). The rate of major complications was 1%.ConclusionsLaparoscopic uterosacral ligament suspension (with or without uterus preservation) seems to be an effective and safe treatment for women with apical POP, but long‐term prospective trials and randomised controlled trials are necessary to confirm these findings.
Real‐world data on patterns and outcomes of radiation therapy for brain metastases in a population‐based cohort of lung cancer patients in Victoria
Authors: Kang Therese Min Jung , Ratnayake Gishan , Wada Morikatsu , Phillips Claire , Ruben Jeremy , Senthi Sashendra , Foroudi Farshad , Millar Jeremy , Ong Wee Loon 
Published: June 2023

AbstractIntroductionWe evaluated real‐world data on the patterns and outcomes of radiotherapy (RT) for brain metastases (BM) in a population‐based cohort of patients with lung cancer (LC) in Victoria.MethodsThe Victorian Radiotherapy Minimum Data set (VRMDS) and the Victorian Cancer Registry (VCR) were linked to identify patients with LC who underwent RT for BM between 2013 and 2016. We determined: (i) proportion of patients treated with stereotactic radiosurgery (SRS); (ii) overall survival (OS); and (iii) 30‐day mortality (30M) following RT for BM.ResultsOf the 1001 patients included in the study, 193 (19%) had SRS. There was no significant increase in SRS use over time – from 18% in 2013 to 21% in 2016 (P‐trend = 0.8). In multivariate analyses, increased age (P = 0.03) and treatment in regional centres (P < 0.001) were independently associated with lower likelihood of SRS treatment. The median OS following RT for BM was 3.6 months. Patients who had SRS had better OS than those who did not have SRS (median OS 8.9 months vs. 3 months, P < 0.01). SRS use, age, sex and year of treatment were independently associated with OS in multivariate analyses. A total of 184 (18%) patients died within 30 days of RT for BM, and the proportion was higher in older (P = 0.001) and male patients (P = 0.004).ConclusionOne‐in‐five LC patients who received RT for BM had SRS. The improved OS with SRS is likely confounded by patient selection. It is important to reduce 30M by better selecting patients who may not benefit from RT for BM.
Adults born prematurely prefer a periviability guideline that considers multiple prognostic factors beyond gestational age
Authors: De Proost L. , de Boer A. , Reiss I. K. M. , Steegers E. A. P. , Verhagen A. A. E. , Hogeveen M. , Geurtzen R. , Verweij E. J. (Joanne) 
Published: June 2023

AbstractAimThe aim of the study was to explore the perspectives of adults born prematurely on guidelines for management at extreme premature birth and personalisation at the limit of viability.MethodsWe conducted four 2‐h online focus group interviews in the Netherlands.ResultsTwenty‐three participants born prematurely were included in this study, ranging in age from 19 to 56 years and representing a variety of health outcomes. Participants shared their perspectives on different types of guidelines for managing extremely premature birth. They agreed that a guideline was necessary to prevent arbitrary treatment decisions and to avoid physician bias. All participants favoured a guideline that is based upon multiple prognostic factors beyond gestational age. They emphasised the importance of discretion, regardless of the type of guideline used. Discussions centred mainly on the heterogeneity of value judgements about outcomes after extreme premature birth. Participants defined personalisation as ‘not just looking at numbers and statistics’. They associated personalisation mainly with information provision and decision‐making. Participants stressed the importance of involving families in decision‐making and taking their care needs seriously.ConclusionAdults born prematurely prefer a periviability guideline that considers multiple prognostic factors and allows for discretion.
Genetic diagnosis of kidney disease by whole exome sequencing and its clinical application
Authors: Jung Jiwon , Lee Joo Hoon , Seo Go Hun , Keum Changwon , Kang Hee Gyung , Cho Heeyeon , Lee Hajeong , Park Su‐Kil , Baek Chung Hee , Han Ro , Lee Sang Taek , Cho Min Hyun , Yim Hyung Eun , Koo Ja wook , Lee Beom Hee 
Published: June 2023

AbstractThe genetic spectrum of genetic kidney diseases (GKD) and the application of genetic diagnoses to patient care were assessed by whole exome sequencing (WES) of the DNA of 172 pediatric or adult patients with various kidney diseases. WES diagnosed genetic diseases in 63 (36.6%) patients. The diagnostic yields in patients with glomerulopathy were 33.8% (25/74 pts) due to variants in 10 genes, 58.8% (20/34) in patients with tubulointerstitial disease due to variants in 18 genes, 33.3% (15/45) in patients with cystic disease/ciliopathy due to variants in 10 genes, 18.2% (2/11) in patients with congenital anomalies of the kidneys and urinary tract (CAKUT) due to variants in two genes, and 12.5% (1/8) in patients with end stage kidney disease (ESKD). The diagnosis rate was high in patients aged <1–6 years (46–50.0%), and low in patients aged ≥40 years (9.1%). Renal phenotype was reclassified in 10 (15.9%) of 63 patients and clinical management altered in 10 (15.9%) of 63 patients after genetic diagnosis. In conclusion, these findings demonstrated the diagnostic utility of WES and its effective clinical application in patients, with various kinds of kidney diseases, across the different age groups.
Popular post‐separation parenting smartphone apps: An evaluation
Authors: Smyth Bruce M. , Payne Jason L. , Irving Michelle , Heard Genevieve 
Published: June 2023

AbstractIn recent years a bewildering array of smartphone applications (“apps”) has emerged to support separated parents' communication. Post‐separation parenting apps vary in cost and features; they typically comprise a messaging tool, shared calendar, expense tracker and a means to export records for legal purposes. A key challenge for separated parents and family law practitioners alike is knowing which apps or app feature(s) can work well for different family contexts, needs and budgets. The present study sought to evaluate nine popular post‐separation parenting apps and their features using small‐n Human–Computer Interaction methods. Mediators role‐played high conflict ex‐couples while completing a set of five common post‐separation communication or organizational tasks. A cross‐case analysis of ratings was conducted. We found that (a) many of the mediators changed their apparent enthusiasm for co‐parenting apps once they had used the apps themselves; (b) all nine apps were rated somewhere between “Poor” to Fair’; and (c) features of some of the best‐known apps were not rated as highly as some of the features of more recent, lesser‐known apps.
Variation in sleep profiles in children with ADHD and associated clinical characteristics
Authors: Sciberras Emma , Hiscock Harriet , Cortese Samuele , Becker Stephen P. , Fernando Julian W. , Mulraney Melissa 
Published: June 2023

BackgroundSleep difficulties are common in children with attention‐deficit/hyperactivity disorder (ADHD). However, sleep problems are multifaceted and little is known about the variation in sleep difficulties across children with ADHD. We examined the profiles of sleep difficulties in children with ADHD and associated clinical factors (e.g. co‐occurring mental health conditions, stimulant use and parent mental health).MethodsData from two harmonised studies of children with ADHD (total: N = 392, ages 5–13 years) were used. Parents completed measures of children's sleep, co‐occurring mental health conditions and their own mental health. Both parents and teachers completed measures of child ADHD symptoms and emotional and conduct symptoms. Latent profile analysis was used to identify sleep profiles, and multinomial logistic regression assessed clinical correlates of the groups.ResultsFive sleep profiles were identified: (a) insomnia/delayed sleep phase (36%), (b) generalised sleep difficulties at sleep onset and overnight (25%), (c) high anxious/bedtime resistance difficulties (11%), (d) overnight sleep difficulties including obstructive sleep apnoea and parasomnias (5%) and (e) no sleep difficulties (22%). Compared with the group without sleep difficulties, the generalised, anxious/bedtime resistance and insomnia/delayed sleep phase sleep had greater parent‐reported emotional and conduct symptoms, co‐occurring anxiety and increased parent mental health difficulties. The generalised and anxious/bedtime resistance groups also had greater parent‐reported ADHD symptoms, with the anxious/bedtime resistance sleep group also having more frequent co‐occurring depression and teacher‐reported emotional symptoms.ConclusionsThe sleep difficulties experienced by children with ADHD are varied. Supports to help children with ADHD need to consider the particular profiles of sleep difficulties experienced and broader clinical characteristics. Tailored intervention approaches are likely needed (including a need to address parent mental health).
Triterpenoids in aerenchymatous phellem contribute to internal root aeration and waterlogging adaptability in soybeans
Authors: Takahashi Hirokazu , Abo Chisato , Suzuki Hayato , Romsuk Jutapat , Oi Takao , Yanagawa Asako , Gorai Tomoka , Tomisaki Yukari , Jitsui Mana , Shimamura Satoshi , Mori Hitoshi , Kaga Akito , Ishimoto Masao , Seki Hikaru , Muranaka Toshiya , Nakazono Mikio 
Published: June 2023

Summary

Soybeans (Glycine max) develop newly differentiated aerenchymatous phellem (AP) in response to waterlogging stress. AP is formed in the hypocotyl and root, thus contributing to internal aeration and adaptation to waterlogging for several legumes. Extensive accumulation of triterpenoids – lupeol and betulinic acid – has been identified in AP. However, their physiological roles in plants remain unclarified. Lupeol is converted from 2,3‐oxidosqualene by lupeol synthase (LUS) and oxidized to betulinic acid. Notably, soybeans have two LUS genes (GmLUS1 and GmLUS2).

Functional analysis was performed to reveal the biological and physiological functions of triterpenoids in AP using lus mutants.

The AP cells of lus1 mutant lacked triterpenoid accumulation and epicuticular wax. Lupeol and betulinic acid were the major components of epicuticular wax and contributed to tissue hydrophobicity and oxygen transport to the roots. Tissue porosity in AP was lower in the lus1 mutant than in the wild‐type, which resulted in reduced oxygen transport to the roots via AP. This reduction in oxygen transport resulted in shallow root systems under waterlogged conditions.

Triterpenoid accumulation in AP contributes to effective internal aeration and root development for adaptation to waterlogging, suggesting the significance of triterpenoids in improving waterlogging tolerance.
Exploring the performance of spectral and textural information for leaf area index estimation with homogeneous and heterogeneous surfaces
Authors: Zhang Yangyang , Han Xu , Yang Jian 
Published: June 2023

AbstractLeaf area index (LAI) is one of the key parameters of vegetation structure, which can be applied in monitoring vegetation growth status. Currently, abundant spatial information (e.g., textural information), provided by the developing remote sensing satellite techniques, could boost the accuracy of LAI estimation. Thus, the performance of spectral and textural information must be evaluated for different vegetation types of LAI estimation in different surface types. In this study, different spectral vegetation indices (SVIs) and grey‐level co‐occurrence matrix‐based textural variables under different moving window sizes were extracted from Landsat TM satellite data. First, the ability of different types of SVIs for LAI estimation in different surface types was analysed. Subsequently, the effect of different texture variables with different moving window sizes towards LAI estimation accuracy in different vegetation types was explored. Lastly, the performance of SVIs combined with textural information for the LAI estimation in different vegetation types was evaluated. Results indicated that SVIs performed better for LAI estimation in the homogeneous region than that in the heterogeneous region, and difference vegetation index was more remarkable for LAI estimation in different vegetation types than other SVIs. In addition, variations in texture variables and moving window sizes had a large influence on LAI estimation of natural vegetation with high canopy heterogeneity. SVI combined with textural information can efficiently improve the accuracy of LAI estimation in different vegetation types (R2 = 0.672, 0.455 and 0.523 for meadow, shrub and cantaloupe, respectively.) compared with SVI alone (R2 = 0.189, 0.064 and 0.431 for meadow, shrub and cantaloupe, respectively.). Especially for natural vegetation (meadow, shrub), the addition of textural information can greatly improve the accuracy of LAI estimation.
Comparison of caregiver burden between dementia with Lewy bodies and Alzheimer's disease
Authors: Yuuki Seiji , Hashimoto Mamoru , Koyama Asuka , Matsushita Masateru , Ishikawa Tomohisa , Fukuhara Ryuji , Honda Kazuki , Miyagawa Yusuke , Ikeda Manabu , Takebayashi Minoru 
Published: June 2023

BackgroundCaring for patients with dementia with Lewy bodies (DLB) would be more stressful for their caregivers than those with Alzheimer's disease (AD). In this study, we compared levels of caregiver burden and the possible influential factors on the caregiver burden between DLB and AD.MethodsNinety‐three DLB patients and 500 AD patients were selected from the Kumamoto University Dementia Registry. Caregiver burden, neuropsychiatric symptoms, basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were assessed by the Japanese version of the Zarit Caregiver Burden Interview (J‐ZBI), the Neuropsychiatric Inventory (NPI), the Physical Self‐Maintenance Scale (PSMS), and the Lawton IADL scale, respectively.ResultsDespite the comparable Mini‐Mental State Examination score, the J‐ZBI score was significantly higher in the DLB group than the AD group (P = 0.012). A stepwise multiple regression analysis revealed that IADL score (β = −0.23, P = 0.049), PSMS score (β = −0.31, P = 0.010), disinhibition (β = 0.22, P = 0.008), and anxiety (β = 0.19, P = 0.027) were significantly associated with J‐ZBI score in DLB. In AD, caregiver's relationship with patient (child) (β = 0.104, P = 0.005), caregiver's gender (female) (β = 0.106, P = 0.004), IADL score (β = −0.237, P < 0.001), irritability (β = 0.183, P < 0.001), apathy (β = 0.132, P = 0.001), agitation (β = 0.118, P = 0.007), and aberrant motor behaviour (β = 0.107, P = 0.010) were associated with caregiver burden.ConclusionsCaring for DLB patients caused a higher degree of caregiver burden than AD patients in the same level of cognitive decline. The factors responsible for the caregiver's burden were different between DLB and AD. The caregiver burden for DLB patients was associated with the disability of basic ADL, IADL impairment, anxiety and disinhibition.
Microbiological environmental contamination in the blood supply chain: An international survey by the bacterial subgroup of the ISBT Transfusion‐Transmitted Infectious Diseases Working Party
Authors: Ramirez‐Arcos Sandra , Garcia‐Otalora Michel , McDonald Carl ,   ISBT Transfusion‐Transmitted Infectious Diseases Working Party, Subgroup on Bacteria
Published: June 2023

AbstractBackground and ObjectivesBlood transfusion centres ensure the quality and safety of transfusable blood components. However, septic transfusion reactions involving environmental contaminants occur. An international survey issued by the ISBT Transfusion‐Transmitted Infectious Diseases Working Party (ISBT‐TTID‐WP) Bacterial Subgroup aimed to collect information regarding microbiological environmental monitoring from transfusion services.Materials and MethodsA Form survey (English and Spanish) with 35 questions was sent to ISBT‐TTID‐WP members. The survey had four sections: (1) respondent personal information, (2) cleaning/disinfection practices during blood component manufacturing, (3) cleaning/disinfection practices during blood component storage and (4) blood component storage bag integrity. Respondents completed the survey electronically, and data were comparatively analysed using Microsoft Excel.ResultsThere were 49 responses from 20 countries. Five of 49 sites manufacture blood components in a cleanroom, and most use personal protective equipment, although the type varied between sites. Approximately 40% of sites perform environmental monitoring during blood component production, with seven sites providing details about frequency and methods. Most (~94%) centres have procedures for cleaning/disinfection of processing and storage facilities with varying responses regarding areas, frequency and methods. Inconsistency was reported regarding the orientation of platelet component incubation (portrait vs. landscape). Over 93% of sites assess storage bag integrity and report damage to manufacturers, and 49% of centres report septic transfusion reactions potentially linked to damaged storage containers.ConclusionData from this survey highlight the need for consensual guidelines for transfusion services regarding cleaning and disinfection practices. Environmental monitoring could be adopted to minimize the risk of blood component contamination for transfusion patient safety.
Predictive Analytics on Scheduled Surgery Cases in Forecasting the Operating Theatre Utilisation
Authors: Ab Rashid Nurul Atiekah , Ya'acob Suraya 
Published: June 2023

The scheduled surgery cases, allocation of clinical provider, machine, equipment, preparation time, surgery performance, and patient recovery give the big impact on OT utilization. Low OT utilization due to no show patient and scheduling bottleneck interrupt patient flow in clinical process. It also decreases the admission to the OT and wastage of resources. In order to improve the capacity of OT, the logical solution need to be carried out is utilization audit. The trend of scheduled surgery cases has identified, and element affect the OT capacity have used to predict the OT optimization for future planning. The purpose of this study is to investigate efficiency of operating theatre (OT) utilization in healthcare institution and the application predictive analytics on its daily operational data. OT contribute to the revenue for the hospital and workload. This project use machine learning in identify which model can use to predict the decision of admission to which facility after the surgery. The model has been going through a few mathematical reasoning to getting the usage efficiency on the dataset. The result shows that Support Vector Machine (SVM) got the highest accuracy in test data rather than Logistic Regression (LR) and Random Forest Classifier. SVM used to predict the admission decision, which contribute to the surgery scheduling in OT. This project can be extended to the admission decision with the factor or severity of patient condition to undergo any intervention in outpatient.
IoT in Banking: The trends, threats, and solution
Authors: Abu Bakar Nur Azaliah , Abu Hassan Mardiana , Hassan Noor Hafizah 
Published: June 2023

The Internet of Things is the next step of the digital revolution that will change consumers' lives. The Internet of Things promises to be a worthy representative of an open course in technology, economics, and culture. IoT, without a doubt, has a promising future. The modern consumer actions and uses represent inescapable digital transformations for banking institutions. Emerging digital world developments guide all banking services' digital transformation. However, the security threats of using IoT in banking are increasing. Cybercriminals such as hacking, corruption, and financial violence, data breaches, and financial expenditure risks will continue to trouble the use of IoT in banking. Therefore, this research aims to study the banking industry's existing IoT uses, issues, and challenges in adopting the IoT in the banking industry. IoT threats are highlighted in this paper. This article sets out a model dimension of the process monitoring framework for IoT security risk management. Other than that, this paper also studies the existing security risk management model of IoT in banking. Moreover, preventive IoT protection initiatives and approaches to enhance IoT protection by implementing blockchain technology and Control Model Information Structure are addressed in this article
Systematic Literature Review: Factor For Physical Security And Access Control in Maximun Security Protection
Authors: Mohamed Roslinda , Abas Hafiza , Hassan Noor Hafizah , Ismail Saiful Adli 
Published: June 2023

Physical security and access control as one of the installations should be upgraded to confirm the security and readiness of the asset belong to the group to continue safely. As the quick development in technology offers a boundless defence level for physical security and access control in the office, every organization must offer a passable budget pertinent to the transformation of the world today. Through a very humane approach of natural surveillance, access control, maintenance, and reinforcements of territory, this strategy will contribute to the field of physical security as a whole. The purpose of this paper is to recognize the features that regulate taking for perimeter protection and access control in maximum were identified and analysed. The findings have revealed that five categories of features can be used to study the taking for perimeter protection and access control in maximum security protection: physical security; access control; security standard and policy; security awareness program and security training and security protection. A Systematic Literature Review (SLR) was accepted since it uses a more rigorous and well-defined method to swotting the study indication pertinent to the study. Initially, 62 papers were retrieved by a manual search in six databases and 17 primary studies were finally included. Consequently, 5 factors education.