bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oscillometry of the Respiratory System in Parkinson's Disease: Physiological Changes and Diagnostic Use
Authors: Caldas Bruno Tavares , Ribeiro Fernando Carlos Vetromille , Pereira João Santos , Souza Wilma Costa , Lopes Agnaldo José , Melo Pedro Lopes 
Published: April 2023

Abstract
Background
Lung function analysis in Parkinson's disease (PD) is often difficult due to the demand for adequate forced expiratory maneuvers. Respiratory oscillometry exams require only quiet tidal breathing and provide a detailed analysis of respiratory mechanics. We hypothesized that oscillometry would simplify the diagnosis of respiratory abnormalities in PD and improve our knowledge about the pathophysiological changes in these patients.
Materials and Methods
This observational study includes 20 controls and 47 individuals with PD divided into three groups (Hoehn and Yahr Scale 1–1.5; H&Y scale 2–3 and PD smokers). The diagnostic accuracy was evaluated by investigating the area under the receiver operating characteristic curve (AUC).
Results
Initial stages are related to increased peripheral resistance (Rp; p = 0.0004). In more advanced stages, a restrictive pattern is added, reflected by changes in dynamic compliance (p < 0.02) and resonance frequency (Fr; p < 0.0001). Smoking PD patients presented increased Rp (p = 0.00015) and Fr (p = 0.007). PD does not introduce changes in the central airways. Oscillometric changes were correlated with respiratory muscle weakness (R = 0.37, p = 0.02). Rp showed adequate accuracy in the detection of early respiratory abnormalities (AUC = 0.858), while in more advanced stages, Fr showed high diagnostic accuracy (AUC > 0.948). The best parameter to identify changes in smoking patients was Rp (AUC = 0.896).
Conclusion
The initial stages of PD are related to a reduction in ventilation homogeneity associated with changes in peripheral airways. More advanced stages also include a restrictive ventilatory pattern. These changes were correlated with respiratory muscle weakness and were observed in mild and moderate stages of PD in smokers and non-smokers. Oscillometry may adequately identify respiratory changes in the early stages of PD and obtain high diagnostic accuracy in more advanced stages of the disease.
The Prognostic Value and Immune Landscaps of m6A/m5C-related LncRNAs signature in the Low Grade Glioma
Authors: Li Ran , Chen Haiyan , Li Chaoxi , Qi Yiwei , Zhao Kai , Wang Junwen , You Chao , Huang Haohao 
Published: April 2023

Abstract
Background: N6-methyladenosine (m6A) and 5-methylcytosine (m5C) are the main RNA methylation modifications involved in the oncogenesis of cancer. However, it remains obscure whether m6A/m5C-related long non-coding RNAs (lncRNAs) affect the development and progression of low grade gliomas (LGG).
Methods: We summarized 926 LGG tumor samples with RNA-seq data and clinical information from the Cancer Genome Atlas and Chinese Glioma Genome Atlas. 105 normal brain samples with RNA-seq data from the Genotype Tissue Expression project were collected for control. 39 m6A/m5C-related genes were used to draw co-expressed lncRNAs network. We obtained a molecular classification cluster from the expression pattern of sreened lncRNAs. The least absolute shrinkage and selection operator (LASSO) Cox regression was employed to construct a m6A/m5C-related lncRNAs prognostic signature of LGG. In vitroexperiments were employed to validate the biological functions of lncRNAs in our risk model.
Results: The expression pattern of 14 sreenedhighly correlated lncRNAs could cluster samples into two groups, in which various clinicopathological features and the tumor immune microenvironment were significantly distinct. The survival time of cluster 1 was significantly reduced compared with cluster 2. This prognostic signature is based on 8 m6A/m5C-related lncRNAs (GDNF-AS1, HOXA-AS3, LINC00346, LINC00664, LINC00665, MIR155HG, NEAT1, RHPN1-AS1). Patients in the high-risk group harbored shorter survival times. Time-ROC curve analysis was confirmed that our model had promising predictive power in survival prediction for both the TCGA (AUC at 1/3/5years respectively: 0.86, 0.84 and 0.77) and CGGA cohorts (AUC at 1/3/5years respectively: 0.73, 0.76 and 0.76). Notably, WHO class II, IDH mutation, 1p/19q co-deletion and MGMT promoter methylation were decreased in the high-risk group. Immunity microenvironment analysis showed B cells, CD4+ T cells, macrophages, and myeloid-derived DC cells were significantly increased in the high-risk group. In addition, patients in high-risk group possessed more CNVs, and higher G-score. Patients in high-risk group had the worse overall survival time regardless of followed TMZ therapy or radiotherapy. All observed results from the TCGA-LGG cohort could be validated in CGGA cohort. Afterwards, we investigated the biological functions of LINC00664 in glioma cells in vitro. LINC00664 was found to promote cell viability, invasion and migration ability of glioma cells.
Conclusion: Our study elucidated a prognostic prediction model of LGG by 8 m6A/m5C methylated lncRNAs and a critical lncRNA regulation function involved in LGG progression. High-risk patients have shorter survival times and a pro-tumor immune microenvironment.
A Scalable, Distributed Monitoring Framework for HPC Clusters Using Redfish-Nagios Integration
Authors: Ali Ghanzanfar , Hass Jon , Sill Alan , Hojati Elham , Dang Tommy , Chen Yong 
Published: April 2023

Abstract
Current monitoring tools for high-performance computing (HPC) systems are often inefficient in terms of scalability and interfacing with modern data center management APIs. This inefficiency leads to a lack of effective management of the infrastructure of modern data centers. Nagios is one of the widely used industry-standard tools for data center infrastructure monitoring, which mainly includes monitoring of nodes and associated hardware and software components. However, current Nagios monitoring has special requirements that introduce several limitations. First, significant human effort is needed for the configuration of monitored nodes in the Nagios server. Second, the Nagios Remote Plugin Executor and the Nagios Service Check Acceptor are required on the Nagios server and each monitored node for active and passive monitoring, respectively. Third, Nagios monitoring also requires monitoring-specific agents on each monitored node. These shortcomings are inherently due to Nagios’ in-band implementation nature. To overcome these limitations, we introduced Redfish-Nagios, a scalable out-of-band monitoring tool for modern HPC systems. It integrates the Nagios server with the out-of-band Distributed Management Task Force’s Redfish telemetry model, which is implemented in the baseboard management controller of the nodes. This integration eliminates the requirements of any agent, plugin, hardware component, or configuration on the monitored nodes. It is potentially a paradigm shift in Nagios-based monitoring for two reasons. First, it simplifies communication between the Nagios server and monitored nodes. Second, it saves computational costs by removing the requirements of running complex Nagios-native protocols and agents on the monitored nodes. The Redfish-Nagios integration methodology enables the monitoring of next-generation HPC systems using the scalable and modern Redfish telemetry model and interface.
Mast cell-driven skewing of DC-Th1 vs. Th2 polarization within TDLNs underlies divergent immune infiltration into TNBC tumors
Authors: Lee Peter , Guo Weihua , Tan Jiayi , Wang Lei , Egelston Colt , Simons Diana , Lim Minhui , Solomon Shawn , Waisman James , Wei Christina , Hoffmann Caroline , Schmolze Daniel 
Published: April 2023

Abstract

Tumor draining lymph nodes (TDLNs) represent a key component of the tumor-immunity cycle. To investigate how TDLNs impact lymphocyte infiltration into tumors, we analyzed non-tumor-invaded LNs draining “cold” vs. “hot” triple negative breast tumors. Using machine-learning based self-correlation analysis of immune gene expression, we found unbalanced intranodal regulations within TDLNCold. Two gene pairs (TBX21/GATA3-CXCR1) with opposite correlations suggested preferential priming of T helper 2 (Th2) cells by mature dendritic cells (mDCs) within TDLNCold. This was validated by multiplex immunofluorescent staining identifying shorter mDC-Th2 distances within TDLNCold. Enrichment in mast cells (MCs) with an independent validation and upregulation of IL4 in TDLNCold supported MC-induced Th2 polarization. Lastly, increased Th2/Th1, IL4/CD3D, and PDGFC/CD68 ratios were observed in paired cold tumors, connecting Th2 polarization in TDLNCold to downstream type 2 immunity within tumors. Our results reveal the novel role of MCs within TDLNs and modulating their activity may improve immune infiltration into tumors.
Model-free fractional-order adaptive prescribed performance control for mechatronic systems with actuator failure
Authors: He Dingxin , Ma Xingyu , Tian Yang , Wang Haoping 
Published: April 2023

Abstract

In this paper, a model-free fractional-order adaptive prescribed performance controller (MFF-APPC) is designed for mechatronic systems in presence of uncertainties, external disturbances and actuator failure. The MFF-APPC is composed of ultra-local model (ULM)-based time-delay estimation (TDE), Proportional-Differential (PD) controller and fractional-order adaptive prescribed performance compensator (FAPPC). The ULM is utilized to approximate the complex mechatronic system in an extra-short sliding time window and TDE is employed to observe and eliminate the lumped disturbance. Then, PD controller is designed to stabilize the closed-loop system. Correspondingly, the TDE-based PD (TDE-PD) controller is constructed. However, there always exists estimation error under TDE technique and the tracking performance cannot be guaranteed. Hence, the FAPPC is designed and introduced into TDE-PD controller to eliminate the effect of estimation error on control performance and constrain the tracking error with prescribed convergence time and precision. Moreover, an adaptive parameter is designed to approximate the upper bound of estimation error in TDE and thus reduces the unwanted chattering on the switching manifold. Correspondingly, the MFF-APPC is constructed. Furthermore, the stability of closed-loop system under the proposed MFF-APPC is analyzed by using Lyapunov theorem. To validate the proposed method, the numerical simulation on 2-DOF robotic manipulator and co-simulation on virtual prototype of 7-DOF iReHave upper limb exoskeleton are completed. Through the compared simulation results with supervising switching technique based adaptive model-free controller (SST-AMFC) and robust fault tolerant controller (RFTC), the proposed strategy shows better trajectory tracking with prescribed performance.
Childhood maltreatment, shame, psychological distress, and binge eating: Testing a serial mediational model
Authors: O’Loghlen Elyse , Galligan Roslyn , Grant Sharon 
Published: April 2023

AbstractObjective: Despite evidence of causal relationships between childhood maltreatment and the development of binge eating disorder (BED), research on mediating mechanisms is lacking. The present study sought to understand the childhood maltreatment-binge eating relationship more fully by examining three types of shame (internal, external, body) and psychological distress as mediators in this relationship. There is evidence that shame and psychological distress are associated with both childhood maltreatment and binge eating pathology. It was hypothesised that shame stemming from childhood maltreatment would contribute to psychological distress, and to binge eating as a dysfunctional emotion regulation strategy, in a serial mediational model.Method: Five hundred and thirty adults with self-reported binge eating symptoms completed an online survey, which included measures of childhood maltreatment, internal shame, external shame, body shame, psychological distress, and binge eating and other eating disorder symptoms.Results: Path analyses showed three specific relationships: (1) a relationship between childhood emotional maltreatment and binge eating, which was serially mediated by internal shame and psychological distress; (2) a relationship between childhood sexual abuse and binge eating, which was mediated by body shame; and (3) a relationship between childhood physical maltreatment and binge eating, which was mediated by psychological distress. The final model showed excellent fit for the data.Discussion: Findings extend our understanding of the link between childhood maltreatment and BED. Future intervention research should focus on examining the efficacy of interventions for different forms of childhood maltreatment, based on the key mediating factors.
Changing the institution of the family doctor in Kazakhstan: the experiences of medical staff and mentors of residents
Authors: Bubeliene Daiva , Merkys Gediminas , Zhamaliyeva Lazzat , Koshmagambetova Gulbakit , Abenova Nurgul , Zhylkybekova Aliya , Kuzembayeva Gulzhana 
Published: April 2023

Abstract
Background At this point in the health care reform process in Kazakhstan, it is very important to fully implement Data Driven Management methods. However, there is a lack of scientific evidence on how this reform, as well as the family doctor’s professional mission and training standards, are perceived by medical practitioners themselves. The study is aimed at revealing the opinions of medical practitioners about primary health care reform and the family doctor’s professional mission and training standards.Methods An interview was used as the qualitative research method in this study. Data from the Kazakhstani focus group research on the family doctor’s professional mission and training standards. The interviews were conducted in four focus groups with experienced health professionals and nurses from Kazakhstan medical institutions where residents do their internships. Each interview group had 8–10 informants.Results As a result of the study, a generalized content and categorization of the subjective perceptions of health professionals were obtained, reflecting their views on the reform of the primary health care sector and on the role of the family doctor and other health professionals.Conclusions Health professionals in Kazakhstan escalate important problems of modern health care and professional development, as well as the interaction of health professionals of different categories – family doctors, specialist doctors and nurse practitioners. At the same time, some of the problems raised have a universal, international character, while others reflect the socio-cultural specificity of healthcare in the countries of the former Eastern bloc.
Construction and experimental validation of a macrophage cell senescence-related gene signature to evaluate the prognosis, immunotherapeutic sensitivity, and chemotherapy response in bladder cancer
Authors: jiang jun , Zhou Junhao , Chen Qi , Huang Yuliang , Yang Cheng , liu cundong 
Published: April 2023

Abstract
Tumor-associated macrophages (TAMs) are pivotal components of tumor microenvironment (TME), and senescent TAMs contribute to the alternation of the profiles of TME. However, the latent biological mechanisms and the prognosis value of senescent macrophages are largely unknown, especially in bladder cancer (BLCA). Based on the single-cell RNA sequencing of a primary BLCA sample, 23 macrophage-related genes were identified. Genomic difference analysis, LASSO, and Cox regression were used to develop the risk model. TCGA-BLCA cohort (n = 406) was utilized as the training cohort, while three independent cohorts (n = 90, n = 221, n = 165) from Gene Expression Omnibus, clinical samples from the local hospital (n = 27), and in vitro cell experiments were used for external validation. Aldo-keto reductase family 1 member B (AKR1B1), inhibitor of DNA binding 1 (ID1), and transforming growth factor beta 1 (TGFB1I1)﻿ were determined and included in the predictive model. The model serves as a promising tool to evaluate the prognosis in BLCA (pooled hazard ratio = 2.51, 95% confidence interval = [1.43; 4.39]). The model was also effective for the prediction of immunotherapeutic sensitivity and chemotherapy treatment outcomes, which were confirmed by IMvigor210 cohort (P < 0.01) and GDSC dataset, respectively. 27 BLCA samples from the local hospital proved that the risk model was associated with the malignant degree (P < 0.05). At last, the human macrophage THP-1 and U937 cells were treated with H2O2 to mimic macrophage senescent process, and the expressions of the molecules in the model were detected (all P < 0.05).
Overall, a macrophage cell senescence-relatedgene signature was constructed to predict the prognosis, immunotherapeutic response, and chemotherapy sensitivity, providing novel insights to uncover the underlying mechanisms.
Asymmetric response of the atmosphere to SST anomalies associated with Kuroshio Extension decadal variability
Authors: Zhang Jianqi , Zhou Li , Huo Fei , Cheng Dong , Yu Kun 
Published: April 2023

Abstract
Using regional climate Model version 4.6, two sets of numerical experiments were designed to investigate the response of atmospheric circulation to symmetric sea surface temperature anomalies (SSTAs) associated with the decadal variability in the Kuroshio Extension (KE) under different atmospheric backgrounds in winter. The results show that the response of the atmosphere to symmetric SSTAs exhibits an asymmetric baroclinic structure related to the stable state of the KE and an equivalent barotropic structure related to the unstable state of the KE under the background of climatology. The diabatic heating associated with cumulus convection and barotropic processes, including irreversible potential vorticity mixing and wave breaking, exerts evident atmospheric circulation and is the main reason for the formation of the asymmetric atmospheric circulation structure. While using a given atmospheric field background in 2008 instead of the climatological background, the response of the atmosphere to SSTAs related to the KE unstable state is similar to the response of the atmosphere to SSTAs related to the KE stable state. The response pattern primarily results from the barotropic processes of nonlinear wave breaking, not the SSTAs coming from the internal variability of the atmosphere at midlatitudes.
The expression of GALNT7, a glycosyltransferase, shows estrogen receptor (ER)-, progesterone receptor (PR)- and HER2-dependent changes in breast cancer with implications in prognosis
Authors: BERKEL CAGLAR , CACAN ERCAN 
Published: April 2023

Abstract
GALNT7 is a glycosyltransferase enzyme transferring N-acetylgalactosamine to initiate O-linked glycosylation in the Golgi apparatus. Breast cancer is the most common cancer in women globally. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2; ERBB2) are important biomarkers in the prognosis and molecular subtyping of breast cancer. Here, we showed that ER-positive, PR-positive or HER2-positive breast cancer tumors have higher expression of GALNT7 compared to ER-negative, PR-negative or HER2-negative breast cancer tumors, respectively. We found that CpG-aggregated methylation of GALNT7 gene is decreased, and in parallel, its transcript levels are increased in breast cancer tumors compared to healthy breast tissue. We observed that the difference in the expression of GALNT7 between negative and positive status of the receptors is the highest for HER2, followed by ER and PR, pointing that HER2 might be relatively more influential than ER and PR on the expression of GALNT7 in breast cancer. We reported that basal-like breast cancer tumors have decreased expression of GALNT7 compared to non-basal-like tumors, and that high GALNT7 expression is associated with favorable relapse-free and distant metastasis-free survival in HER2 status-dependent manner in breast cancer patients. Moreover, we showed that GALNT7 expression in breast cancer is cell type (epithelial vs stromal cells), tumor grade and ethnicity-dependent. Combined, we propose that GALNT7 might contribute to different clinical outcomes depending on the receptor status in breast cancer, and that a better understanding of GALNT7 and its function in the context of breast cancer is needed.
Histogram Analysis of Computed Tomography Images to Differentiate Lacrimal Lymphoma and Lacrimal Inflammatory Pseudotumor
Authors: Zhang Siyao , Yuan Ting , Wan Huijuan , Zhao Xinrong , Lian Haidong 
Published: April 2023

Abstract
Background To investigate the value of the histogram analysis to identify between lacrimal lymphoma(LL) and lacrimal inflammatory pseudotumor(LIP).
Methods CT images of 30 patients with LL and 43 patients with LIP were analyzed for imaging features and histogram parameters. Tumor morphology and histogram parameters of LL and LIP were compared. Receiver operating characteristic (ROC) analysis of area under the curve (AUC), sensitivity, and specificity were used to measure the differential diagnostic efficacy of these parameters.
Results Compared those in LIP group，lesions in LL group were more bilateral and had clearer boundary (P= .036 and .000, respectively), while no significant difference of other CT features was found between groups(all P> .05). The variance of the LIP group were greater than that of the LL group, with statistically significant differences (P=.000). The mean, skewness, kurtosis, 1th, 10th, and 50th percentiles of the LL group were greater than those of the LIP group, with statistically significant differences (all P＜.05). Acceptable discrimination was detected between LL and LIP with mean, variance, skewness, kurtosis, 1th, 10th, and 50th percentiles alone (AUC =0.789, 0.825, 0.716, 0.762, 0.624, 0.719, and 0.666 respectively). The combination of these histogram parameters yielded excellent discrimination between LL and LIP(AUC = 0.961), with sensitivity and specificity values greater than 0.800.
Conclusions Histogram analysis of CT images is feasible for differentiating LL from LIP. It can be used as a supplementary tool for differentiating the lacrimal tumors.
Effects of acute piano performance with blood flow restriction on upper limb muscle and perceptual response in pianists
Authors: Yasuda Tomohiro , Sato Yumi , Nakajima Toshiaki 
Published: April 2023

Abstract
We investigated the physiological and perceptual responses related to piano performance with or without moderate blood flow restriction (BFR) based on acute responses of neuromuscular mechanisms. Student or professional pianists (n = 7) performed the "Revolutionary Etude" on the piano with (Piano-BFR) and without (Piano-Ctrl) BFR. During the Piano-BFR performance, 150–180 mmHg of cuff pressure was applied around the most proximal region of both arms as a moderate BFR. Changes in upper limb girth, muscle thickness, and hand grip strength were measured before and immediately after the performance. After the performance, perceptual and other responses were recorded. Immediately after the performance, the Piano-BFR condition induced greater changes in girth (forearm and upper arm), muscle thickness (forearm), and handgrip strength than the Piano-Ctrl condition. Piano-BFR was (p < 0.01) higher than Piano-Ctrl on eight questions regarding perceptual response (upper arm fatigue and difficulty playing the piano). Piano performance with BFR was revealed to increase upper extremity muscle size and fatigue in pianists after playing. The effect of BFR on neuromuscular mechanisms on piano performance was greater in the forearm than in the upper arm.