bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial Complex I activity is inhibited by changes in the abundance of phosphatidylinositol and phosphatidylserine in wheat plants exposed to high temperatures
Authors: Malone Aygul , Rupasinghe Thusitha W. , Roessner Ute , Taylor Nicolas L. 
Published: February 2023

AbstractIdentifying the molecular basis of thermotolerance in crops is becoming increasingly important with the changing climatic conditions that challenge future food security. Sustaining cellular energy production under heat stress is vital in maintaining an uninterrupted growth cycle, and thus the mitochondria is instrumental in facilitating the overall heat-tolerance of a crop plant. Using targeted mass spectrometry, the changes in abundance of the lipo-protein network in mitochondrial membranes following a short episode of extremely high temperature were analysed in two wheat cultivars of differing thermotolerance. The results indicated that membrane lipids remodel in favour of shorter fatty acyl tails, and an increase in the abundance of phosphatidylinositol, while specific to the heat-tolerant cultivar was an increase in the abundance of phosphatidylserine. The differences between the lipid profiles of the two cultivars is a likely explanation for the decrease in Complex I NADH dehydrogenase activity in the heat-sensitive cultivar. Further metabolite analysis by LC-MS revealed malate accumulation, indicating that the disruption in Complex I activity impacts the catabolism of reducing equivalents. The measured increase in the total amount of phosphatidylserine in the heat-tolerant cultivar suggests a potential role in conveying thermotolerance for this minor membrane constituent, and highlights that a focus on membrane lipid composition during thermal stress will be essential for the breeding of future heat tolerant crops.SummaryWe evaluated changes to the lipo-protein network of wheat mitochondria of differing heat tolerance in response to heat shock.Using targeted mass spectrometry, candidate transitions were selected to quantify changes in membrane lipids and the embedded protein components of the electron transport chain, which play a vital role in maintaining respiration.A significant increase in phosphatidylserine was exclusive to the mitochondria of the heat-tolerant wheat cultivar. In the absence of this, the heat-sensitive cultivar displayed a reduced Complex I activity.The minor membrane constituent phosphatidylserine plays a role in conveying thermotolerance, making this membrane lipid a focal point for the breeding of future heat tolerant crops.
A Rapid review on the COVID-19 Pandemic’s Global Impact on Breast Cancer Screening Participation Rates and Volumes from January-December 2020
Authors: Lee Reagan , Xu Wei , Dozier Marshall , McQuillan Ruth , Theodoratou Evropi , Figueroa Jonine D. 
Published: February 2023

AbstractBackgroundCOVID-19 has strained population breast mammography screening programs that aim to diagnose and treat breast cancers earlier. As the pandemic has affected countries differently, we aimed to quantify changes in breast screening volume and uptake during the first year of the COVID-19 pandemic.MethodsWe systematically searched Medline, the WHO (World Health Organization) COVID-19 database, and governmental databases. Studies covering January 2020 to March 2022 were included. We extracted and analyzed data regarding study methodology, screening volume and uptake. To assess for risk-of-bias, we used the Joanna Briggs Institute Critical Appraisal tool.ResultsTwenty-six cross-sectional descriptive studies were included out of 935 independent records. Reductions in screening volume and uptake rates were observed among eight countries. Changes in screening participation volume in five countries with national population-based screening ranged from -13% to –31%. Among two countries with limited population-based programs the decline ranged from -61% to -41%. Within the USA, population participation volumes varied ranging from +18% to -39% with suggestion of differences by insurance status (HMO, Medicare, and low-income programs). Almost all studies had high risk-of-bias due to insufficient statistical analysis and confounding factors.Discussion and ConclusionExtent of COVID-19-induced reduction in breast screening participation volume differed by region and data suggested potential differences by healthcare setting (e.g., national health insurance vs private health care). Recovery efforts should monitor access to screening and early diagnosis to determine if prevention services need strengthening to increase coverage of marginalized groups and reduce disparities.
Durga: An R package for effect size estimation and visualisation
Authors: Khan Md Kawsar , McLean Donald James 
Published: February 2023

AbstractStatistical analysis and data visualisation are integral parts of science communication. One of the major issues in current data analysis practice is an over-dependency on – and misuse of –p-values. Researchers have been advocating for the estimation and reporting of effect sizes for quantitative research to enhance the clarity and effectiveness of data analysis. Reporting effect sizes in scientific publications has until now been mainly limited to numeric tables, even though effect size plotting is a more effective means of communicating results, however, statistical software for plotting effect sizes is currently limited.We have developed the Durga R package to estimate and plot effect sizes. Durga allows users to estimate unstandardised and standardised effect sizes and bootstrapped confidence intervals of the effect sizes. The central functionality of Durga is to combine effect size visualisations with traditional plotting methods.Durga is a powerful statistical and data visualisation package that is easy to use, providing the flexibility to estimate effect sizes of paired and unpaired data using different statistical methods. Durga provides a plethora of options for plotting effect size, which allows users to plot data in the most informative and aesthetic way.Here, we introduce the package and its various functions. We further describe a workflow for estimating and plotting effect sizes using example data sets.
Oviposition-related behaviours ofLimenitis camillain a common garden experiment
Authors: Marcantonio M. , Vodă R. , Da Re D. , Igot Q , Dennis R.L.H. , Vielfaure A. , Vanwambeke S.O. , Nieberding C.M 
Published: February 2023

ABSTRACTHuman induced environmental changes are accelerating at an unprecedented pace, forcing organisms to rapidly adjust their behaviours. There is broad evidence that the main driver of the ongoing biodiversity crisis is land-use change, that reduces and fragments natural habitats. However, the consequence of habitat fragmentation on behavioural responses of fitness-related traits such as oviposition site selection in insects, which represent about 50% of \ Earth’s species diversity, have been so far understudied. In herbivorous insects, oviposition-related behaviours determine larval food access, and thus the fate of the next generation. We present a pilot study to assess differences in oviposition-related behaviours inLimenitis camillabutterflies from Wallonia (Belgium), one of the most fragmented regions in Europe. We first quantified variation in functional habitat connectivity forL. camillaacross Wallonia and found that fragmented habitats had more abundant, but less evenly distributedLonicera periclymenum, the host plant ofL. camilla. Secondly, we compared in a semi-natural experimental setting the behaviours of field-caughtL. camillafemales originating from habitats with contrasted landscape connectivity. We found differences in behaviours related to flight investment: butterflies from fragmented woodlands spent more time in non-compass orientation flight, which we associated with dispersal, than butterflies from homogenous woodlands, whereL. periclymenumwas less abundant and more evenly distributed. Although results from this study should be interpreted with caution given the limited sample size, they provide valuable insights for the advancement of behavioral research that aims to assess the effects of global changes on insects.
Insulin signaling regulatesPink1mRNA localization via modulation of AMPK activity to support PINK1 function in neurons
Authors: Hees J. Tabitha , Harbauer Angelika B. 
Published: February 2023

AbstractMitochondrial quality control failure is frequently observed in neurodegenerative diseases. The detection of damaged mitochondria by stabilization of PTEN-induced kinase 1 (PINK1) requires transport ofPink1mRNA by tethering it to the mitochondrial surface. Here, we report that inhibition of AMPK by activation of the insulin signaling cascade preventsPink1mRNA binding to mitochondria. Mechanistically, AMPK phosphorylates the RNA anchor complex subunit SYNJ2BP within its PDZ domain, a phosphorylation site that is necessary for its interaction with the RNA-binding protein SYNJ2. Interestingly, loss of mitochondrialPink1mRNA association upon insulin addition is required for PINK1 protein activation and its function as a ubiquitin kinase in the mitophagy pathway, thus placing PINK1 function under metabolic control. Induction of insulin-resistancein vitroby the key genetic Alzheimer-risk factor apolipoprotein E4 retainsPink1mRNA at the mitochondria and prevents proper PINK1 activity especially in neurites. Our results thus identify a metabolic switch controllingPink1mRNA localization and PINK1 activity via insulin and AMPK signaling in neurons and propose a mechanistic connection between insulin resistance and mitochondrial dysfunction.
Plastic and sustainability: a bibliometric analysis using VOSviewer and CiteSpace
Authors: Zhang Jiale , Quoquab Farzana , Mohammad Jihad 
Published: February 2023

PurposeThis study aims to present a comprehensive knowledge mapping and an in-depth analysis of plastic and sustainability research to understand better global trends and directions in this field that emerged between 1995 and 2022.Design/methodology/approachThis study presents a visual analysis of 1933 research articles listed in the Web of Science (WoS) databases between the years 1995 and 2022 related to plastic and sustainability. The knowledge mapping based on CiteSpace and VOSviewer presents the current research status, which contains the analysis of the collaboration network, co-citation network, references with citation bursts and keyword analysis.FindingsThe results reveal that China and the USA are the most prominent countries in exploring the notion of sustainability and plastic. The Chinese Academy of Science is the most prominent institution. Chai Qiang, Friedrich Daniel, Sahajwalla Veena and Ok Yong Sik are the most prolific authors in this field. Furthermore, circular economy, bioplastic, sustainable development, polyester and bioplastics are the highly discussed issues in recent years. Not surprisingly, COVID-19 is the latest topic of discussion started in 2021 due to its negative impact on plastic pollution and the challenges it posed to sustainability.Originality/valueThis study is among the pioneers to shed light on the current research status of plastic and sustainability using the bibliometric method and the newest data. This study also suggests that collaborations between scholars and institutions require to be enhanced for better management of plastic pollution and to contribute to sustainable development.
Eco-innovation of food processing and manufacturing SMEs
Authors: Riaz Adil , Ali Fouzia , Ashfaq Khurram , Bhatti Anam , Rehman Shafique Ur 
Published: February 2023

PurposeThis study aims to investigate the impact of green shared vision (GSV) and green knowledge sharing (GKS) on eco-innovation types and further investigates the impact of these types on sustainable competitive advantage (SCA) and sustainable business performance (SBP) within the food manufacturing and food processing small- and medium-sized enterprises (SMEs) of a developing country.Design/methodology/approachPartial least square structural equation modeling technique was used to test the hypotheses. Simple random sampling was used, and data were collected from 312 owners/managers of food manufacturing and processing SMEs.FindingsThe results reveal a significant positive relationship between GSV, GKS and eco-innovation types. Furthermore, it was revealed that all three types of eco-innovation are significantly related to SCA and SBP.Practical implicationsThe results of this research will assist food manufacturing and food processing SMEs in reducing their eco-footprint to gain SCA and SBP. Furthermore, policymakers and governing bodies may implement strong regulations to curtail eco-pollution.Originality/valueTo the best of the authors' knowledge, this is the first study that incorporates the concept of eco-innovation in food processing and food manufacturing SMEs of a developing country in the light of the natural resource orchestration theory.
Processors' understanding of process quality: a qualitative interview study with employees of organic dairies in Germany and Switzerland
Authors: Borghoff Lisa Marie , Strassner Carola , Herzig Christian 
Published: February 2023

PurposeOrganic food processing must include organic principles to be authentic. This qualitative study aims to understand the processors' understanding of organic food processing quality.Design/methodology/approachThis study is based on semi-structured expert interviews with eight employees of six purely or partly organic dairies from Germany and Switzerland. Interview themes are (1) quality of organic milk processing in general, (2) assessment of specific processing techniques, (3) product quality of organic milk and (4) flow of information between producer and consumer. The interviews have been audio-recorded, transcribed verbatim and thematically analysed.Findings(1) Experts prefer minimal processing; some prefer artisanal processing, whilst others stress the advantages of mechanisation. (2) High temperature short time (HTST) pasteurisation and mechanical processing techniques are accepted; ultra-high-temperature (UHT) milk processing is partly rejected. (3) Traditional taste and valuable ingredients should be present in the final product. Natural variances are judged positively. (4) Consumers' low level of food technology literacy is challenging for communication.Research limitations/implicationsThe results cannot be generalised due to the qualitative study design. Further studies, e.g. qualitative case analyses and studies with a quantitative design, are necessary to deepen the results.Practical implicationsThe paper shows which processing technologies experts consider suitable or unsuitable for organic milk. The paper also identifies opportunities to bridge the perceived gap between processors' and consumers' demands.Originality/valueThe study shows the challenges of processors in expressing the processors' understanding of process quality.
Social media sensing framework for urban infrastructure management: a Philippine case study
Authors: Do Sy Tien , Nguyen Viet Thanh , Banlasan Denver 
Published: February 2023

Purpose
This study aims to use social media data mining to revitalize and support existing urban infrastructure monitoring strategies by extracting valuable insights from public opinion, as current strategies struggle with issues such as adaptability to changing conditions, public engagement and cost effectiveness.

Design/methodology/approach
Twitter messages or “Tweets” about public infrastructure in the Philippines were gathered and analyzed to discover reoccurring concerns in public infrastructure, emerging topics in public debates and the people’s general view of infrastructure services.

Findings
This study proposes a topic model for extracting dominating subjects from aggregated social media data, as well as a sentiment analysis model for determining public opinion sentiment toward various urban infrastructure components.

Originality/value
The findings of this study highlight the potential of social media data mining to go beyond the limitations of traditional data collection techniques, as well as the importance of public opinion as a key driver for more user-involved infrastructure management and as an important social aspect that can be used to support planning and response strategies in routine maintenance, preservation and improvement of urban infrastructure systems.
From EAP to BHAP: a conceptual framework to develop and implement a comprehensive behavioral health access program within the fire service
Authors: ODare Kellie , Bator Chris , Butler Lance , Orrange Jeffrey , Porter Lauren , Rehbein Michelle , Dilks John , Dillard Dana R. , King Erin , Herzog Joseph , Rotunda Robert 
Published: February 2023

PurposeThe purpose of this paper is to articulate the results of a comprehensive literature review and grassroots outreach with first responder organizations to present an operationalized framework for organizations to utilize as a blueprint in developing customized behavioral health access program (BHAP) programs.Design/methodology/approachHistorically, authorities having jurisdiction (AHJ)over fire service organizations have primarily offered behavioral health interventions through Employee Assistance Programs (EAPs) or commercial insurance carriers. These programs are necessary but may prove insufficient to meet the scope and needs of trauma-exposed firefighters and the firefighters' families.FindingsA BHAP is a comprehensive and operationalized plan which clearly specifies the mental health services fire department members and families need, where those services are available within their communities and levels and standards of care that are expected in the provision of these services.Originality/valueThe BHAP is becoming a world standard of behavioral health care for first responders. While some fire service agencies are beginning to create BHAP guides, developing and implementing a BHAP can be time consuming and overwhelming, particularly for departments with limited internal and external resources. While the results of this review focus on BHAP within the fire service, this framework is applicable across all first responder professions.
Ensuring sustainability in internationalisation efforts at higher education institutions
Authors: Leal Filho Walter , Viera Trevisan Laís , Dinis Maria Alzira Pimenta , Sivapalan Subarna , Wahaj Zujaja , Liakh Olena 
Published: February 2023

Purpose
Higher education institutions (HEIs) around the world are engaged in internationalisation efforts. Yet internationalisation per se is associated with significant pressures on the environment and environmental resources, which need to be addressed. This study aims to assess the opportunities, benefits and challenges associated with the internationalisation of universities at a global level.

Design/methodology/approach
A total of 27 relevant case studies were extracted from the literature to illustrate how HEIs worldwide are ensuring sustainability in their internationalisation efforts.

Findings
Through case studies of international HEIs, the study lists the opportunities, benefits and challenges associated with the internationalisation of universities at a global level and some of the measures that may be deployed to reduce the environmental impacts of their international activities.

Originality/value
This study provides a welcome contribution to the literature because it outlines some of the works taking place at universities, where matters related to sustainable development are considered against a background of internationalisation efforts.
Delineating protective boundaries using the HUL approach a case study: heritage waterways of Isfahan
Authors: Chitsazzadeh Elnaz , Chizfahm Daneshmandian Mahsa , Jahani Najmeh , Tahsildoost Mohammad 
Published: February 2023

PurposeThe UNESCO recommendation under the historic urban landscapes (HUL) title and Operational Guidelines (OPG) were used to create dynamic protective boundaries to maintain the integrity and authenticity of Isfahan's heritage waterways. Accordingly, by using GIS and Isfahan urban layers, three protective zones were proposed and evaluated; the central zone, the functional zone and the visual zone.Design/methodology/approachHeritage waterways in historic cities are not adequately protected against the negative impacts of urban development, and there is a lack of a dynamic protective system to protect their integrity and authenticity. The problem can be observed in Isfahan, a historic Iranian city, where the boundaries of urban heritage waterways (Madi canals) are usually rigid and arbitrary. This study aims to develop a practicable paradigm for determining protection boundaries for Isfahan's Jolfa Madi, an urban heritage waterway.FindingsCompared to the current protective boundaries, the authors found that proposed protective boundaries create a greater amount of protection space, which makes a strong connection among the ecological, historical and socio-economic characteristics of the urban context. Furthermore, the protective zones based on the HUL approach give Isfahan's urban planning policy the opportunity to consider participatory tools, financial tools and regulatory systems.Originality/valueMany studies have emphasized a fixed-width buffer or an arbitrary distance from the urban waterway's axis (urban heritage) or its banks. Although these protections include technical conservation or setting restrictions on the adjacent buildings and blocks, studying crucial concepts such as urban dynamic, urban heritage context and producing a particular technique for protected boundaries has not been investigated. In this article three dynamic boundaries are delineated with various functions in order to provide urban heritage with dynamic preservation and sustainable development for the historic urban landscapes.
The initial survival of the Unicorns: a behavioral perspective of Snapchat
Authors: Cristofaro Matteo , Giannetti Federico , Abatecola Gianpaolo 
Published: February 2023

Purpose
Unicorn companies, such as Facebook, Uber, and Airbnb, significantly impact our economies. This happens although they had a dramatic initial start – at least in terms of financial performance – that would have let any other “conventional” business close. In other words, Unicorns challenge the start-ups’ problems traditionally associated with early failure (liability of newness). This paper aims to understand what helps Unicorn firms initially survive despite huge losses.

Design/methodology/approach
By adopting a behavioral lens, this historical case study article focuses on key strategic decisions regarding the famous social media Unicorn Snapchat from 2011 to 2022. The case combines secondary data and a thematic analysis of Snapchat founders’ and investors’ interviews/comments to identify the behavioral antecedents leading to Snapchat’s honeymoon.

Findings
Snapchat network effect triggered cognitive biases of Snapchat founders’ and investors’ decisions, leading them to provide initial assets (i.e. beliefs/goodwill, trust, financial resources and psychological commitment) to the nascent Unicorn. Therefore, the network effect and biases resulted in significant antecedents for Snapchat’s honeymoon.

Originality/value
The authors propose a general, theoretical framework advancing the possible impact of biases on Unicorns’ initial survival. The authors argue that some biases of the Unicorns’ founders and investors can positively support a honeymoon period for these new ventures. This is one of the first case studies drawing on a behavioral approach in general and on biases in particular to investigate the liability of newness in the Unicorns’ context.