bluuebunny/crossref_metadata_2025_split huggingface dataset:
Work-family interface and children's mental health: a systematic review
Authors: Bilodeau Jaunathan , Mikutra-Cencora Maya , Quesnel-Vallée Amélie 
Published: March 2023

AbstractThe COVID-19 pandemic and the public health measures adopted to contain it have highlighted the centrality of the work-family interface in the etiology of mental health among the employed population. However, while the impact on the mental health of workers has been well documented, the relationship with the mental health of children of those workers remains to be clarified.A systematic review was conducted through the identification of peer-reviewed studies on the association between parental work-family interface (e.g. work-family conflict and/or work-family enrichment) and children’s mental health. This method is based on the consultation of 7 databases (MEDLINE, PubMed, Web of Science, PsycINFO, SocIndex, Embase, and Scopus), considering all studies published through June 2022 (PROSPERO: CRD42022336058). Methodology and findings are reported according to the PRISMA guidelines. 25 of the 4146 identified studies met our inclusion criteria. Quality appraisal was performed using a modified Newcastle–Ottawa scale. Most studies investigated only work-family conflict, ignoring work-family enrichment. Child mental health outcomes evaluated included internalizing behaviours (n = 11), externalizing behaviours (n = 10), overall mental health (n = 13), and problematic Internet usage (n = 1). Results of the review are summarized qualitatively. Our analysis shows equivocal evidence for the direct relationships between the work-family interface and children’s mental health, as a large proportion of associations did not reach statistical significance. We can, however, posit that work-family conflict seems to be more associated with children’s mental health problems while work-family enrichment was more related to children’s positive mental health. A greater proportion of significant associations are observed for internalizing behaviors compared to externalizing behaviors. Almost all the studies that test for a mediating effect found that parental characteristics and parental mental health are significant mediators.Our research provides insight into the complex association between work-family interface and child mental health, showing both beneficial and detrimental consequences that may even occur simultaneously. This highlights the far-reaching effects of contexts affecting the work-family interface, including the COVID-19 pandemic. We conclude with the need for research adopting more standardized and nuanced measures of the work-family interface to further validate these conclusions.
Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy
Authors: Tu Zewei , Wang Chong , Hu Qing , Tao Chuming , Fang Zhansheng , Lin Li , Lei Kunjian , Luo Min , Sheng Yilei , Long Xiaoyan , Li Jingying , Wu Lei , Huang Kai , Zhu Xingen 
Published: March 2023

Abstract
Introduction
Increasing evidence has revealed the key activity of protein disulfide isomerase A4 (PDIA4) in the endoplasmic reticulum stress (ERS) response. However, the role of PDIA4 in regulating glioblastoma (GBM)-specific pro-angiogenesis is still unknown.

Methods
The expression and prognostic role of PDIA4 were analyzed using a bioinformatics approach and were validated in 32 clinical samples and follow-up data. RNA-sequencing was used to search for PDIA4-associated biological processes in GBM cells, and proteomic mass spectrum (MS) analysis was used to screen for potential PDIA4 substrates. Western blotting, real-time quantitative polymerase chain reaction (RT-qPCR), and enzyme-linked immunosorbent assays (ELISA) were used to measure the levels of the involved factors. Cell migration and tube formation assays determined the pro-angiogenesis activity of PDIA4 in vitro. An intracranial U87 xenograft GBM animal model was constructed to evaluate the pro-angiogenesis role of PDIA4 in vivo.

Results
Aberrant overexpression of PDIA4 was associated with a poor prognosis in patients with GBM, although PDIA4 could also functionally regulate intrinsic GBM secretion of vascular endothelial growth factor-A (VEGF-A) through its active domains of Cys-X-X-Cys (CXXC) oxidoreductase. Functionally, PDIA4 exhibits pro-angiogenesis activity both in vitro and in vivo, and can be upregulated by ERS through transcriptional regulation of X-box binding protein 1 (XBP1). The XBP1/PDIA4/VEGFA axis partially supports the mechanism underlying GBM cell survival under ER stress. Further, GBM cells with higher expression of PDIA4 showed resistance to antiangiogenic therapy in vivo.

Conclusions
Our findings revealed the pro-angiogenesis role of PDIA4 in GBM progression and its potential impact on GBM survival under a harsh microenvironment. Targeting PDIA4 might help to improve the efficacy of antiangiogenic therapy in patients with GBM.
Impact of the route of adrenaline administration in patients suffering from out-of-hospital cardiac arrest on 30-day survival with good neurological outcome (ETIVIO study)
Authors: Monaco Tobias , Fischer Matthias , Michael Mark , Hubar Iryna , Westenfeld Ralf , Rauch Stefan , Gräsner Jan-Thorsten , Bernhard Michael 
Published: March 2023

Abstract
Background
Over the past decades, international guidelines for cardiopulmonary resuscitation (CPR) have changed the recommendation for alternative routes for drug administration. Until now, evidence for the substantial superiority of one route with respect to treatment outcome after CPR has been lacking. The present study compares the effects of intravenous (IV), intraosseous (IO) and endotracheal (ET) adrenaline application during CPR in out-of-hospital cardiac arrest (OHCA) on clinical outcomes within the database of the German Resuscitation Registry (GRR).

Methods
This registry analysis was based on the GRR cohort of 212,228 OHCA patients between 1989 and 2020. Inclusion criteria were: OHCA, application of adrenaline, and out-of-hospital CPR. Excluded from the study were patients younger than 18 years, those who had trauma or bleeding as suspected causes of cardiac arrest, and incomplete data sets. The clinical endpoint was hospital discharge with good neurological outcome [cerebral performance category (CPC) 1/2]. Four routes of adrenaline administration were compared: IV, IO, IO + IV, ET + IV. Group comparisons were done using matched-pair analysis and binary logistic regression.

Results
In matched-pair group comparisons of the primary clinical outcome hospital discharge with CPC 1/2, the IV group (n = 2416) showed better results compared to IO (n = 1208), [odds ratio (OR): 2.43, 95% confidence interval (CI): 1.54–3.84, p < 0.01] and when comparing IV (n = 8706) to IO + IV (n = 4353), [OR: 1.33, 95% CI: 1.12–1.59, p < 0.01]. In contrast, no significant difference was found between IV (n = 532) and ET + IV (n = 266), [OR: 1.26, 95% CI: 0.55–2.90, p = 0.59]. Concurrently, binary logistic regression yielded a highly significant effect of vascular access type (χ² = 67.744(3), p < 0.001) on hospital discharge with CPC1/2, with negative effects for IO (regression coefficient (r.c.) = − 0.766, p = 0.001) and IO + IV (r.c. = − 0.201, p = 0,028) and no significant effect for ET + IV (r.c. = 0.117, p = 0.770) compared to IV.

Conclusions
The GRR data, collected over a period of 31 years, seem to emphasize the relevance of an IV access during out-of-hospital CPR, in the event that adrenaline had to be administered. IO administration of adrenaline might be less effective. ET application, though removed in 2010 from international guidelines, could gain importance as an alternative route again.
Impact on the ability of healthcare professionals to correctly identify patient-ventilator asynchronies of the simultaneous visualization of estimated muscle pressure curves on the ventilator display: a randomized study (Pmus study)
Authors: Silva Daniel Oliveira , de Souza Patrícia Nery , de Araujo Sousa Mayson Laercio , Morais Caio Cesar Araujo , Ferreira Juliana Carvalho , Holanda Marcelo Alcantara , Yamaguti Wellington Pereira , Junior Laerte Pastore , Costa Eduardo Leite Vieira 
Published: March 2023

Abstract
Background
Patient-ventilator asynchronies are usually detected by visual inspection of ventilator waveforms but with low sensitivity, even when performed by experts in the field. Recently, estimation of the inspiratory muscle pressure (Pmus) waveforms through artificial intelligence algorithm has been proposed (Magnamed®, São Paulo, Brazil). We hypothesized that the display of these waveforms could help healthcare providers identify patient-ventilator asynchronies.

Methods
A prospective single-center randomized study with parallel assignment was conducted to assess whether the display of the estimated Pmus waveform would improve the correct identification of asynchronies in simulated clinical scenarios. The primary outcome was the mean asynchrony detection rate (sensitivity). Physicians and respiratory therapists who work in intensive care units were randomized to control or intervention group. In both groups, participants analyzed pressure and flow waveforms of 49 different scenarios elaborated using the ASL-5000 lung simulator. In the intervention group the estimated Pmus waveform was displayed in addition to pressure and flow waveforms.

Results
A total of 98 participants were included, 49 per group. The sensitivity per participant in identifying asynchronies was significantly higher in the Pmus group (65.8 ± 16.2 vs. 52.94 ± 8.42, p < 0.001). This effect remained when stratifying asynchronies by type.

Conclusions
We showed that the display of the Pmus waveform improved the ability of healthcare professionals to recognize patient-ventilator asynchronies by visual inspection of ventilator tracings. These findings require clinical validation.
Trial registration: ClinicalTrials.gov: NTC05144607. Retrospectively registered 3 December 2021.
Different effects of cardiometabolic syndrome on brain age in relation to gender and ethnicity
Authors: Kang Sung Hoon , Liu Mengting , Park Gilsoon , Kim Sharon Y. , Lee Hyejoo , Matloff William , Zhao Lu , Yoo Heejin , Kim Jun Pyo , Jang Hyemin , Kim Hee Jin , Jahanshad Neda , Oh Kyumgmi , Koh Seong-Beom , Na Duk L. , Gallacher John , Gottesman Rebecca F. , Seo Sang Won , Kim Hosung 
Published: March 2023

Abstract
Background
A growing body of evidence shows differences in the prevalence of cardiometabolic syndrome (CMS) and dementia based on gender and ethnicity. However, there is a paucity of information about ethnic- and gender-specific CMS effects on brain age. We investigated the different effects of CMS on brain age by gender in Korean and British cognitively unimpaired (CU) populations. We also determined whether the gender-specific difference in the effects of CMS on brain age changes depending on ethnicity.

Methods
These analyses used de-identified, cross-sectional data on CU populations from Korea and United Kingdom (UK) that underwent brain MRI. After propensity score matching to balance the age and gender between the Korean and UK populations, 5759 Korean individuals (3042 males and 2717 females) and 9903 individuals from the UK (4736 males and 5167 females) were included in this study. Brain age index (BAI), calculated by the difference between the predicted brain age by the algorithm and the chronological age, was considered as main outcome and presence of CMS, including type 2 diabetes mellitus (T2DM), hypertension, obesity, and underweight was considered as a predictor. Gender (males and females) and ethnicity (Korean and UK) were considered as effect modifiers.

Results
The presence of T2DM and hypertension was associated with a higher BAI regardless of gender and ethnicity (p < 0.001), except for hypertension in Korean males (p = 0.309). Among Koreans, there were interaction effects of gender and the presence of T2DM (p for T2DM*gender = 0.035) and hypertension (p for hypertension*gender = 0.046) on BAI in Koreans, suggesting that T2DM and hypertension are each associated with a higher BAI in females than in males. In contrast, among individuals from the UK, there were no differences in the effects of T2DM (p for T2DM*gender = 0.098) and hypertension (p for hypertension*gender = 0.203) on BAI between males and females.

Conclusions
Our results highlight gender and ethnic differences as important factors in mediating the effects of CMS on brain age. Furthermore, these results suggest that ethnic- and gender-specific prevention strategies may be needed to protect against accelerated brain aging.
PSMD2 contributes to the progression of esophageal squamous cell carcinoma by repressing autophagy
Authors: Liu Yachen , Wu Meng , Xu Shuxiang , Niu Xiangjie , Liu Weiling , Miao Chuanwang , Lin Ai , Xu Yang , Yu Lili 
Published: March 2023

Abstract
Background
The ubiquitin–proteasome and autophagy-lysosomal systems collaborate in regulating the levels of intracellular proteins. Dysregulation of protein homeostasis is a central feature of malignancy. The gene encoding 26S proteasome non-ATPase regulatory subunit 2 (PSMD2) of the ubiquitin–proteasome system is an oncogene in various types of cancer. However, the detailed role of PSMD2 in autophagy and its relationship to tumorigenesis in esophageal squamous cell carcinoma (ESCC) remain unknown. In the present study, we have investigated the tumor-promoting roles of PSMD2 in the context of autophagy in ESCC.

Methods
Molecular approaches including DAPgreen staining, 5-Ethynyl-2ʹ-deoxyuridine (EdU), cell counting kit 8 (CCK8), colony formation, transwell assays, and cell transfection, xenograft model, immunoblotting and Immunohistochemical analysis were used to investigate the roles of PSMD2 in ESCC cells. Data-independent acquisition (DIA) quantification proteomics analysis and rescue experiments were used to study the roles of PSMD2 in ESCC cells.

Results
We demonstrate that the overexpression of PSMD2 promotes ESCC cell growth by inhibiting autophagy and is correlated with tumor progression and poor prognosis of ESCC patients. DIA quantification proteomics analysis shows a significant positive correlation between argininosuccinate synthase 1 (ASS1) and PSMD2 levels in ESCC tumors. Further studies indicate that PSMD2 activates the mTOR pathway by upregulating ASS1 to inhibit autophagy.

Conclusions
PSMD2 plays an important role in repressing autophagy in ESCC, and represents a promising biomarker to predict prognosis and a therapeutic target of ESCC patients.
Management-related energy, nutrient and worktime efficiencies of the wood fuel production and supply chain: modelling and assessment
Authors: Bilot Nicolas , Deleuze Christine , Saint-André Laurent , Rogaume Yann , Fournier Meriem , Wernsdörfer Holger 
Published: March 2023

AbstractContextBioenergy from wood can contribute to reach the goals of energy-transition policies. Use of wood as fuel should focus on low-quality wood, e.g. by-products from timber production, which production and supply is related to various management decisions. Reaching the policy objectives efficiently remains an issue.AimsThe aims are (1) to develop a modelling approach that links local management decisions with indicators of the whole wood fuel production and supply chain and (2) to test the model in a case study. The study should further provide first insights on how indicators of energy, nutrient and worktime efficiency vary according to wood fuel chain characteristics and the related management decisions.MethodsThe model depicts the flow of wood (biomass, nutrients, moisture content, heating value) from the forest stand to the heating plant for each silvicultural intervention simulated with a growth and yield model. It further quantifies the energy and worktime spent on different wood fuel chain tasks (e.g. felling, forwarding) set by the user. We defined four scenarios according to the scale of energy production (large vs. small) and the demand for wood fuel (high vs. moderate).ResultsThe case study revealed that the model outputs were plausible. Energy efficiency largely varied depending on the type of silvicultural intervention. Large-scale production associated with high demand was most favourable for energy and worktime efficiencies. In contrast, nutrient efficiency was best for small-scale production associated with moderate demand.ConclusionsLocal management decisions all along the wood fuel chain highly influenced efficiency indicators, and thus its relevance for energy-transition policies. Our model may contribute to strategic decision making in different forestry and energy production contexts.
Mitofusin2 expression is associated with podocyte injury in IgA nephropathy
Authors: Tang Xuanli , Yuan Yuan , Liang Xiaoli , Jiang Xue 
Published: March 2023

Abstract
Background
Podocyte injury is associated with IgA nephropathy (IgAN) prognosis. Mitochondrial dysfunction is a major contributor to podocyte injury and death. Mitofusin2 (Mfn2) plays an important role in regulating the morphology and function of mitochondria. This study aimed to investigate the potential of Mfn2 as a biomarker to evaluate the degree of podocyte injury.

Methods
This single-center, retrospective study enrolled 114 patients with biopsy-proven IgAN. Immunofluorescence and TUNEL staining were applied, and clinical and pathological features were compared between patients with different patterns of Mfn2 expression.

Results
In IgAN, Mfn2 is mainly expressed in podocytes and significantly associated with nephrin, TUNEL, and Parkin staining. Among the 114 IgAN patients, 28 (24.56%) did not exhibit Mfn2 expression in podocytes. The patients in the Mfn2-negative group had lower serum albumin (34.43 ± 4.64 g/L vs. 36.48 ± 3 .52 g/L, P = 0.015) and estimated glomerular filtration rate (eGFR) (76.59 ± 35.38 mL/min vs. 92.13 ± 25.35 mL/min, P = 0.013), higher 24 h proteinuria (2.48 ± 2.72 g/d vs. 1.27 ± 1.31 g/d, P = 0.002), serum creatinine (Scr) (107.39 ± 57.97 μmol/L vs. 84.70 ± 34.95 μmol/L, P = 0.015), blood urea nitrogen (BUN) (7.36 ± 4.45 mmol/L vs. 5.68 ± 2.14 mmol/L, P = 0.008), and higher S/T scores (92.86% vs. 70.93% and 42.85% vs. 15.12%, respectively, P < 0.05).
In the Mfn2-negative group, the mitochondria were punctate and round ridges disappeared, and a lower length-to-width ratio and much higher M/A ratio were observed. Correlation analysis showed that the intensity of Mfn2 was negatively correlated with Scr (r = − 0.232, P = 0.013), 24 h proteinuria (r = − 0.541, P = 0.001), and the degree of podocyte effacement (r = − 0.323, P = 0.001), and positively correlated with eGFR (r = 0.213, P = 0.025).
Logistic regression analysis showed that the Mfn2-negative group had a higher risk of severe podocyte effacement (≥ 50%) (OR = 3.061, P = 0.019).

Conclusion
Mfn2 was negatively correlated with proteinuria and renal function. A lack of Mfn2 in podocytes indicates severe podocyte injury and a high degree of podocyte effacement.
The clinical impact of IKZF1 mutation in acute myeloid leukemia
Authors: Zhang Xiang , Huang Aijie , Liu Lixia , Qin Jiayue , Wang Chengcheng , Yang Min , Lou Yinjun , Wang Lei , Ni Xiong , Hu Xiaoxia , Tang Gusheng , Zhang Mengmeng , Cao Shanbo , Mao Liping , Qian Jiejin , Xu Weilai , Wei Juying , Xu Gaixiang , Meng Haitao , Mai Wenyuan , Yang Chunmei , Zhu Honghu , Tong Hongyan , Yang Jianmin , Yu Wenjuan , Wang Jianmin , Jin Jie 
Published: March 2023

AbstractGenetic heterogeneity poses a great challenge to the understanding and management of acute myeloid leukemia (AML). Knowledge of the IKZF1 mutation in AML specifically is extremely limited. In a previous work, we described the distribution pattern of IKZF1 mutation in AML, but its clinical impact has remained undefined due to the limited number of cases. Herein, we attempt to answer this question in one relatively large cohort covering 522 newly diagnosed AML patients. A total of 26 IKZF1 mutations were found in 20 AML patients (20/522, 3.83%). This condition has a young median age of onset of morbidity (P = 0.032). The baseline characteristics of IKZF1-mutated and wild-type patients were comparable. IKZF1 mutation showed significant co-occurrences with CEBPA (P < 0.001), SF3B1 (P < 0.001), and CSF3R (P = 0.005) mutations, and it was mutually exclusive with NPM1 mutation (P = 0.033). Although IKZF1-mutated AML was more preferably classified into the intermediate-risk group (P = 0.004), it showed one inferior complete remission rate (P = 0.032). AML with high burden of IKZF1 mutation (variant allele frequency > 0.20) showed relatively short overall survival period (P = 0.012), and it was an independent factor for the increased risk of death (hazard ratio, 6.101; 95% CI 2.278–16.335; P = 0.0003). In subgroup analysis, our results showed that IKZF1 mutation conferred poor therapeutic response and prognosis for SF3B1-mutated AML (P = 0.0017). We believe this work improves our knowledge of IKZF1 mutation.
Favorable locations for new VGOS antennas in India depending on the assessment of geodetic parameters and environmental factors
Authors: Dhar Sujata , Glaser Susanne , Heinkelmann Robert , Schuh Harald , Balasubramanian Nagarajan , Dikshit Onkar 
Published: March 2023

AbstractVLBI simulation studies are carried out to investigate the impact of any proposed station or strategy on the geodetic parameters, such as Earth Orientation Parameters (EOP) and Terrestrial Reference Frame (TRF). In general, such studies are performed for making decisions on any new development in the existing VLBI network. Thus, for selecting the favorable locations for establishment of a VLBI antenna in India, simulation studies are performed on 42 potential locations to cover the whole Indian subcontinent. Furthermore, the simulation setup is divided into four scenarios that consider the current and future situations of the global VLBI network. Extensive simulation strategy is applied with optimized scheduling for each network geometry, Monte-Carlo simulations and analysis in the VieSched++ software. Since only the simulation results are thought to be insufficient for a thorough evaluation of the realistic performance of locations, environmental factors are also investigated in the current study. The environmental factors affecting the operation and vulnerability of the VLBI technique at the potential locations are also incorporated in the present study. For this, a weighted scoring model is developed with the scores and weights based on the probable impact and occurrence frequency of disrupting environmental events, respectively. This approach will avoid the possibility of new VLBI station ending up in an unfavorable location in India and, underperforming substantially in terms of the achieved improvement of geodetic parameters as determined from the simulation study. The VLBI Global Observing System (VGOS) network is being established at a global level to create a uniformly distributed network of the next generation VLBI system to meet the goals of the Global Geodetic Observing Systems (GGOS). India is planning to establish its first VGOS antenna, and therefore, this study helps to mark the high-performance favorable locations for VGOS. The improvements in geodetic parameters of favorable locations identified in the simulation study are 6.7–11.2% in the first scenario, 12.8–46.8% in second scenario, 9–20.5% in third scenario and 2.9–6.1% in fourth scenario. The favorable locations outperform other Indian locations by a factor of 1.1–5.8. In addition to that, the Indian locations having environmental factors that might affect the VGOS adversely are not portrayed as the favorable choice.
Graphical Abstract