bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitis vinifera L. Bioactive Components Modulate Adipose Tissue Metabolic Markers of Healthy Rats in a Photoperiod‐Dependent Manner
Authors: Navarro‐Masip Èlia , Manocchio Francesca , Colom‐Pellicer Marina , Escoté Xavier , Iglesias‐Carres Lisard , Calvo Enrique , Bravo Francisca I , Muguerza Begoña , Desjardins Yves , Aragonès Gerard 
Published: July 2023

ScopeThe beneficial health effects of (poly)phenol‐rich foods such as red grapes mainly depend on both the type and concentration of (poly)phenols. Since fruit (poly)phenol content is influenced by growing conditions, the study examines the seasonal effects of red grapes (Vitis vinifera L.), grown under various cultivation conditions, on metabolic markers of adipose tissue in healthy rats.Methods and resultsFor this purpose, Fischer 344 rats are exposed into three different light‐dark cycles and daily supplemented with 100 mg kg−1 of either conventionally or organically grown red grapes for 10 weeks (n = 6). Seasonal consumption of organic grapes (OGs), which are richer in anthocyanins, increases energy expenditure (EE) of animals exposed to long photoperiod and enhances uncoupling protein 1 (UCP1) protein expression in brown adipose tissue of animals under standard photoperiod. Additionally, red grape consumption affects the gene expression profile of white adipose tissue (WAT), upregulating browning markers of subcutaneous WAT in 12 h light (L12) and 18 h light (L18) photoperiods, and downregulating adipogenic and lipolytic markers of visceral WAT in 6 h light (L6) and L12 photoperiods.ConclusionsThese results clearly show that bioactive compounds of grapes can modulate the metabolic markers of white and brown adipose tissues in a photoperiod and depot‐dependent manner, partly affecting EE when consumed out of season.
Comprehensive analysis of cuproptosis‐related gene expression and positive correlations with CD4+ T cell infiltration in head and neck squamous cell carcinoma
Authors: Hu Zhangwei , Lei Wenbin , Wen Weiping 
Published: July 2023

AbstractCuproptosis is a novel form of copper‐induced programmed cell death. Here, we investigate the role of cuproptosis‐related genes in head and neck squamous cell carcinoma (HNSCC), and the correlations between cuproptosis‐related genes and tumor‐infiltrating immune cells in the microenvironment. Gene expression data were downloaded from TCGA and analyzed using R. Protein–protein interaction analysis was conducted using STRING and GeneMANIA, while survival analyses examined the correlations between genes and overall survival. In addition, analyses of methylation and mutation sites were performed using Illumina HumanMethylation450 data and the cBioPortal data set, respectively. The correlations between gene expression level and infiltrating immune cells and predictive values of PD‐1/PD‐L1 blockade responses were also analyzed. Cuproptosis‐promoting genes were downregulated, while two out of three cuproptosis‐inhibiting genes, GLS and CDKN2A, showed upregulated expression. The CDKN2A expression level was identified as an independent prognostic factor for HNSCC through the multivariate Cox survival analysis. Meanwhile, levels of all cuproptosis‐related genes correlated positively with CD4+ T cell infiltration. Furthermore, expression of the cuproptosis‐promoting gene DLD was negatively correlated with immune score. All cuproptosis‐related genes were expressed aberrantly and correlated positively with CD4+ T cell infiltration in HNSCC. Thus, copper homeostasis and cuproptosis could be targeted therapeutically as a potential means of enhancing the efficacy of immunotherapy.
Design guidance of a circularly polarized bowtie antenna for ISM bands
Authors: Venouil Anton , Egels Matthieu , Benwadih Mohammed , Serbutoviez Christophe , Pannier Philippe 
Published: July 2023

AbstractThis article presents the design steps of a planar circularly polarized (CP) bowtie‐shaped antenna for 2.4–2.5 GHz industry, science, and medicine band. Using these design steps, an antenna model is developed. The antenna design is extensively described, simulated, measured, and analyzed. The antenna is simulated using the HFSS software and produced by laser etching of copper on a low‐cost Taconic RF‐35 substrate. The presented method of this design is easy to fabricate and is tunable to different frequencies. The produced CP planar antenna has a size of 55 × 55 × 0.25 mm3, a measured axial ratio bandwidth ranging from 2.33 to 2.49 GHz, and a measured peak gain of 3.21 dBiC. The produced antenna is fully planar, compatible with the printing process and thus suitable for Internet of Things applications.
Fiber optic sensor for transformer temperature detection
Authors: Shen Tao , Yuan Yue , Chen Qingguo , Xu Shaoyi , Zheng Wenlei , Xiao Hao , Liu Dongchao , Liu Dongwei , Zhao Senlin 
Published: July 2023

AbstractThe safe and stable operation of the transformer is affected by the internal temperature. Therefore, it is very necessary to accurately and effectively detect the temperature of the transformer winding. To realize the effective detection of the internal temperature of the transformer, a fiber optic temperature sensor based on the structure of multimode fiber (MMF)–no core fiber (NCF)–multimode fiber (MMF) (i.e., MMF–NCF–MMF) is studied. The temperature sensitivity reaches 0.0313 nm/°C. Moreover, to enhance the accuracy of the test, the sensitive material polydimethylsiloxane (PDMS) is coated on the sensing area (the position of the NCF), and its temperature sensitivity reaches 0.123 nm/°C. By comparison, it was found that the temperature detection sensitivity increased by 3.93 times after coating PDMS. The sensor has the characteristics of simple structure, high sensitivity, and high integration, which provides research and application directions for temperature detection in the field of transformer health detection.
A mid‐infrared laser absorption sensor for calibration‐free measurement of nitric oxide in laminar premixed methane/ammonia cofired flames
Authors: Li Qing , Ji Feiyu , Wang Wei , Ma Liuhao , Wang Yu 
Published: July 2023

AbstractAn interband cascade laser (ICL)‐based absorption sensor was developed for calibration‐free and high‐fidelity measurement of nitric oxide (NO) in laminar premixed methane/ammonia cofired flames using a combination of a micro‐probe and a low‐pressure, high‐temperature gas cell. The developed sensor, which has been shown to be particularly suitable for kinetic studies of ammonia combustion, used a tunable, continuous, narrow‐linewidth, free‐space ICL operating at ~5.2 μm to target the optimal NO transition centered at 1900.07 cm−1. A direct absorption spectroscopy technique with a reduced line model was implemented for calibration‐free measurements. Comprehensive experiments were first conducted to evaluate the sensor performance against the standard gas mixture at varied pressure from 20 to 101 kPa at 393 K, showing a relative difference of ≤2.5% and a measurement uncertainty of ≤2.0%. Such a sensor shows a minimum detection limit of ~2 ppm at the integration time of 1 s. The sensor was then applied for investigating the NO formation in ammonia‐methane cofiring flames with various ammonia blending ratios; the acquired experimental data was further used as benchmark data for evaluation of literature chemical mechanisms for ammonia combustion. The developed sensor system was demonstrated to be capable of providing quantitative and spatially resolved measurement of NO in ammonia‐methane cofired flames.
A wideband single‐layer slotted patch antenna for millimeter wave 5G applications
Authors: Mustapha Ademola A. , Hussain Rifaqat , Abou‐Khousa Mohamed A. 
Published: July 2023

AbstractA slotted microstrip patch antenna for fifth‐generation (5G) mobile applications is presented in this paper. The proposed antenna addresses the intrinsic narrow bandwidth of patch antennas by introducing rectangular slots in the form of a disjointed H‐slot to broaden the bandwidth. The patch design and the slots introduce two extra resonances to broaden the bandwidth of the antenna. An impedance bandwidth of 26.6% from 24.95 to 32.6 GHz was achieved. A measured peak gain of 9.44 dBi was also achieved with a minimum half‐power beamwidth of 36° over the entire bandwidth. The proposed slotted patch antenna is implemented on a 44.6 mm × 26.3 mm × 0.8 mm RT5880 Printed Circuit Board.
Long term outcomes and causal modelling of compulsory inpatient and outpatient mental health care using Norwegian registry data: Protocol for a controversies in psychiatry research project
Authors: Hofstad Tore , Nyttingnes Olav , Markussen Simen , Johnsen Erik , Killackey Eoin , McDaid David , Rinaldi Miles , Dean Kimberlie , Brinchmann Beate , Douglas Kevin , Gröning Linda , Bjørkly Stål , Palmstierna Tom , Strømme Maria Fagerbakke , Blindheim Anne , Rugkåsa Jorun , Hofmann Bjørn Morten , Pedersen Reidar , Widding‐Havneraas Tarjei , Rypdal Knut , Mykletun Arnstein 
Published: July 2023

AbstractObjectivesCompulsory mental health care includes compulsory hospitalisation and outpatient commitment with medication treatment without consent. Uncertain evidence of the effects of compulsory care contributes to large geographical variations and a controversy on its use. Some argue that compulsion can rarely be justified and should be reduced to an absolute minimum, while others claim compulsion can more frequently be justified. The limited evidence base has contributed to variations in care that raise issues about the quality/appropriateness of care as well as ethical concerns. To address the question whether compulsory mental health care results in superior, worse or equivalent outcomes for patients, this project will utilise registry‐based longitudinal data to examine the effect of compulsory inpatient and outpatient care on multiple outcomes, including suicide and overall mortality; emergency care/injuries; crime and victimisation; and participation in the labour force and welfare dependency.MethodsBy using the natural variation in health providers' preference for compulsory care as a source of quasi‐randomisation we will estimate causal effects of compulsory care on short‐ and long‐term trajectories.ConclusionsThis project will provide valuable insights for service providers and policy makers in facilitating high quality clinical care pathways for a high risk population group.
Digitally delivered education and exercises for patients with hand osteoarthritis—An observational study
Authors: Walter Matthias Michael , Sirard Paulina , Nero Håkan , Hörder Helena , Dahlberg Leif E. , Tveter Anne Therese , Kjeken Ingvild , Kiadaliri Ali 
Published: July 2023

AbstractHand osteoarthritis (OA) is a common form of OA, for which education and exercise are considered the first‐line treatment. The aim of the present study was to examine pain and perceived hand function in participants following 3 months of digitally delivered first‐line treatment for hand OA. Three‐hundred‐and‐seventy‐nine of 846 participants with clinical signs and symptoms of hand OA completed the study. The digital hand OA treatment program consists of video instructed daily exercises and patient education through text lessons. Pain (NRS, 0 no pain, 10 worst) was the primary outcome, and stiffness (NRS) and the Functional Index for Hand OsteoArthritis (FIHOA, 0 best, 30 worst) were among secondary outcomes. The McNemar test and linear mixed effect regression model were used to assess the changes in outcomes from baseline to 3‐month. After three months, the digitally delivered program was associated with a significant decrease in pain intensity (mean change −1.30 (95% CI −1.49, −1.12)) and hand stiffness (mean change ‐0.81 (95% CI −1.02, −0.60)) but no conclusive changes in the FIHOA scores (mean change 0.3 (95% CI −0.2, 0.7)). The results agree with reports on face‐to‐face delivered first‐line treatment for hand OA suggesting that digital treatment is a viable treatment option in patients with hand OA.
Dental disease and dietary patterns in coastal Phoenicia during the Roman period
Authors: Mardini Mahmoud , Badawi Ali , Zaven Tania , Gergian Raffi , Nikita Efthymia 
Published: July 2023

AbstractThe current paper presents one of the first bioarchaeological studies on dental disease and dietary patterns in coastal Phoenicia during the Roman period, focusing on the dentition of 145 adults from the contemporary and geographically proximal sites of Byblos, Beirut, and Tyre. Pathological conditions of the oral cavity and dental wear were used to assess intra‐assemblage and inter‐assemblage differences. Byblos in almost all instances exhibited higher levels of dental diseases and wear than Beirut and Tyre, suggesting a greater consumption of carbohydrates but also poorer oral hygiene and greater mechanical stress (dental wear) in this community. This difference between Beirut/Tyre and Byblos may be explained by the politico‐economic status of these cities as textual sources highlight the economic and political prowess of Beirut and Tyre due to their status as colonia. In addition, within each assemblage females generally exhibited higher caries (and associated periapical cavities and ante‐mortem tooth loss) than males. Although dental caries may be linked to nondietary factors, these patterns may support a more cariogenic diet for females in agreement with literary accounts reciting gender‐based divisions in Roman society, at least to the extent that these would manifest in dietary patterns. The findings from this study offer important insights into major and understudied communities along the Phoenician coast. Yet, further research is required, employing complementary methods (e.g., isotopic analysis and dental calculus microdebris) and including larger datasets of Roman Phoenician assemblages.
HPV16 E6 and E7 are involved in inhibition of autophagy and maintenance of cancer stem cell properties in HPV16‐positive oral squamous cell carcinoma cells
Authors: Shigeishi Hideo , Sugiyama Masaru , Akagi Misaki , Kaneyasu Yoshino , Maehara Tomoko , Ohta Kouji 
Published: July 2023

AbstractAimThe involvement of human papillomavirus (HPV) E6/E7 in autophagy has not been fully elucidated in oral squamous cell carcinoma (OSCC) cells. The objective of this study was to clarify the association between HPV E6/E7 and autophagy and cancer stem cell properties such as self‐renewal ability and chemotherapy resistance in HPV16‐positive OSCC cells.MethodsUM‐SCC‐104 HPV16‐positive OSCC cells were cultured on laminin 332‐coated silicone gel. The impact of HPV16 E6 or E7 siRNA transfection on cell proliferation, spheroid formation, 5‐fluorouracil (5‐FU)‐induced cell death, and autophagy was investigated. After treatment with rapamycin, DAPGreen was used to detect autophagosome formation.ResultsHPV16 E6 or E7 siRNA transfection resulted in knockdown of both E6 and E7 in UM‐SCC‐104 cells. HPV16 E6/E7 knockdown inhibited cell proliferation, mRNA expression of stem cell markers (i.e., CD44, ALDH1, BMI1, OCT4, and NANOG), and spheroid formation. Furthermore, HPV16 E6/E7 knockdown enhanced 5‐FU‐induced cell death. Additionally, mRNA expression of autophagy‐related genes such as ATG5 and BECN1 was significantly increased after HPV16 E6/E7 knockdown. Furthermore, HPV16 E6/E7 knockdown augmented rapamycin‐induced autophagy. Next, we found that miR‐30a‐5p is indicated to interact with the 3′‐untranslated region of ATG5 and BECN1 using TargetScan. However, significant induction of autophagy was not found after miR‐30a‐5p inhibitor transfection. Importantly, 5‐FU‐induced cell death was significantly attenuated by chloroquine autophagy inhibitor in HPV16 E6/E7 knockdown cells.ConclusionHPV16 E6/E7 is involved in autophagy regulation as well as in the maintenance of cancer stem cell features in OSCC cells.
Students' ratings of school climate as a moderator between self‐esteem and internalizing symptoms in a community‐based high school population
Authors: de Arellano Abigail , Neger Emily N. , Rother Yvette , Bodalski Elizabeth , Shi Dexin , Flory Kate 
Published: July 2023

AbstractThe prevalence of anxiety and depression symptoms in adolescents is increasing. Both self‐esteem and school climate have been found to predict mental health symptoms in adolescents and young adults, though little is known about how these constructs interact. The purpose of the current study was to examine the moderating role of school climate in the relation between self‐esteem and internalizing concerns in a weighted, stratified sample of high school students. Ninety‐five participants ages 14–19 (51.43% male) completed self‐report measures of self‐esteem (Rosenberg Self‐Esteem Scale), school climate (Psychological Sense of School Membership Scale), and internalizing symptoms (Revised Child Anxiety and Depression Scale). There were significant negative correlations between all internalizing concerns and both self‐esteem and school climate. Significant moderating effects of school climate were found such that students' ratings of low self‐esteem were more strongly associated with depression, generalized anxiety, and panic symptoms when they perceived a poorer school climate. Low self‐esteem was related to social anxiety, while perception of poor school climate was associated with separation anxiety and obsessive‐compulsive symptoms. School climate may act as a protective factor, buffering the relation between low self‐esteem and depression and some anxiety subtypes in adolescents. Implications for prevention and intervention are discussed.
Predicting the seasonal flight activity of Myzus persicae, the main aphid vector of Virus Yellows in sugar beet
Authors: Luquet Martin , Poggi Sylvain , Buchard Christelle , Plantegenest Manuel , Tricault Yann 
Published: July 2023

AbstractBACKGROUNDVirus Yellows (VY), a disease caused by several aphid‐borne viruses, is a major threat to the global sugar beet production. Following the ban of neonicotinoid‐based seed treatments against aphids in Europe, increased efforts are needed to monitor and forecast aphid population spread during the sugar beet growing season. In particular, predicting aphid flight seasonal activity could allow anticipation of the timing and intensity of crop colonisation and contribute to the proper implementation of management methods. Forecasts should be made early enough to assess risk, but can be updated as the season progresses to refine management. Based on a long‐term suction‐trap dataset gathered between 1978 and 2014, we built and evaluated a set of models to predict the flight activity features of the main VY vector, Myzus persicae, at any location in the French sugar beet production area (c. 4 × 105 ha). Flight onset dates, length of flight period and cumulative abundance of flying aphids were predicted using climatic and land‐use predictors as well as geographical position.RESULTSOur predictions outperformed current models published in the literature. The importance of the predictor variables varied according to the predicted flight feature but winter and early spring temperature always played a major role. Forecasts based on temperature were made more accurate by adding predictors related to aphid winter reservoirs. In addition, updating the model parameters to take advantage of new weather data acquired during the season improved the flight forecast.CONCLUSIONOur models can be used as a tool for the mitigation in sugar beet crops. © 2023 Society of Chemical Industry.
Icariin, a phytoestrogen, exerts rapid estrogenic actions through crosstalk of estrogen receptors in osteoblasts
Authors: Wong Ka‐Ying , Kong Tsz‐Hung , Poon Christina Chui‐Wa , Yu Wenxuan , Zhou Liping , Wong Man‐Sau 
Published: July 2023

AbstractIcariin, a flavonoid glycoside derived from Epimedium brevicornum Maxim, exerts bone protective effects via estrogen receptors (ERs). This study aimed to investigate the role of ER‐α66, ER‐α36, and GPER in bone metabolism in osteoblasts following treatment with icariin. Human osteoblastic MG‐63 cells and osteoblast‐specific ER‐α66 knockout mice were employed. The ERs crosstalk in the estrogenic action of icariin was evaluated in ER‐α66‐negative human embryonic kidney HEK293 cells. Icariin, like E2, regulated ER‐α36 and GPER protein expression in osteoblasts by downregulating them and upregulating ER‐α66. ER‐α36 and GPER suppressed the actions of icariin and E2 in bone metabolism. However, the in vivo administration of E2 (2 mg/kg/day) or icariin (300 mg/kg/day) restored bone conditions in KO osteoblasts. ER‐α36 and GPER expression increased significantly and rapidly activated and translocated in KO osteoblasts after treatment with E2 or icariin. ER‐α36 overexpression in KO osteoblasts further promoted the OPG/RANKL ratio induced by E2 or icariin treatment. This study showed icariin and E2 elicit rapid estrogenic responses in bone through recruiting ER‐α66, ER‐α36, and GPER. Notably, in osteoblasts lacking ER‐α66, ER‐α36, and GPER mediate the estrogenic effects of icariin and E2, while in intact osteoblasts, ER‐α36 and GPER act as negative regulators of ER‐α66.
Distributed prescribed‐time leader‐following formation control for second‐order multi‐agent systems with mismatched disturbances
Authors: Li Bo , Gong Wenquan , Xiao Bing , Yang Yongsheng 
Published: July 2023

AbstractThis article investigates the distributed prescribed‐time formation control problem for the second‐order multi‐agent systems (MASs) subject to matched and mismatched disturbances in time‐varying formation case. As a stepping stone, novel distributed estimators are first proposed to accurately estimate the position and velocity information of the leader within prescribed time. Subsequently, the nominal control protocol is presented for the MAS in the absence of the disturbances to deal with the time‐varying formation control problem, and the prescribed‐time stability of the system is guaranteed. For system subject to matched and mismatched disturbances, the observer‐based integral sliding mode formation control protocol is then presented such that the desired trajectories can be tracked and the desired patterns can be achieved within the prescribed settling time. By adopting the sinusoidal function to the control scheme, the singularity‐like problem is solved if there exist measurement errors in the agents. Finally, a numerical simulation example utilizing unmanned aerial vehicles modeled by Simscape and Solidworks is presented to show the efficiency of the proposed scheme.
Generalized outer synchronization and parameters identification of uncertain delayed hypernetworks with stochastic noises
Authors: Wang Xiong , Gu Haibo , Lü Jinhu , Liu Kexin 
Published: July 2023

AbstractSynchronization of hypernetworks has been extensively researched due to its potential applications in various contexts, such as secure communications and power grid engineering. However, the existing works thus far have primarily been devoted to inner synchronization or complete outer synchronization with identical node dynamics and topology structures. To investigate harmonious coexistence between two networks with nonidentical node dynamics and reduce control costs as well, this paper focuses on generalized outer synchronization (GOS) and parameters identification of uncertain delayed hypernetworks with stochastic noises. Regardless of whether the node parameters are known or not, based on Lyapunov stability and the LaSalle‐type invariance principle for stochastic differential equations with multiple delays, some sufficient conditions are exhibited to reach GOS almost surely via adaptive control schemes. Moreover, the unknown node parameter vectors are identified by the designed updating laws. In addition, some corollaries are deduced and indicate that our proposed methods contain single‐layer networks and complete synchronization methods as special cases. Furthermore, numerical simulations are provided to verify the effectiveness of our approaches. In particular, it is revealed that network parameters, including time delays, coupling strengths, and noise intensities, have an impact on the performance of the proposed algorithms.