bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal-on-metal metaphyseal and ceramic-on-ceramic femoral neck arthroplasty: the impact on clinical results, oxidative stress and concentration of metal ions in serum and blood
Authors: Stołtny Tomasz , Dobrakowski Michał , Augustyn Aleksander , Kasperczyk Sławomir , Rokicka Dominika , Skowroński Rafał , Strojek Krzysztof , Koczy Bogdan 
Published: April 2023

Abstract
Purpose
Growing number of hip arthroplasty in Poland performed with the use of metaphyseal stems results from the decreasing age of patients qualified for procedures and is consistent with the corresponding trends in European countries. To this day, a significant population functions after undergoing hip replacement using metal-on-metal implant. This study was aimed at the assessment of the variability of the oxidative system, as well as the concentrations of chromium and cobalt ions in serum and blood and their potential impact on postoperative clinical status.

Material and methods
The analysis included 58 men. The first group—operated using J&J DePuy ASR metal-on-metal implant with metaphyseal stem ProximaTm. Second group—operated using K-Implant SPIRON® femoral neck prosthesis in full ceramic articulation. Selected parameters of oxidative stress and the antioxidant system as well as the concentration of metal ions in blood were determined twice. Each patient underwent two clinical evaluations using acclaimed physical examination scale systems.

Results
In the first group, significantly higher concentrations of Cr (p = 0.028) and Co (p = 0.002) were demonstrated compared to the group of femoral neck arthroplasty. The mean concentrations of Cr and Co, 10.45 and 9.26 μg/l, respectively, were higher in patients operated bilaterally. In the ASR group, greater pain intensity in the operated hip and higher indicators of oxidative stress were found.

Conclusions
Metal-on-metal articulation of the hip significantly increases the concentration of Cr and Co in blood, induces oxidative stress and modifies function of the antioxidant system and generates greater pain in the operated hip.
Identification of functional pathways and potential genes associated with interferon signaling during human adenovirus type 7 infection by weighted gene coexpression network analysis
Authors: Yang Zhongying , Wei Jianhua , He Yu , Ren Luo , Chen Shiyi , Deng Yu , Zang Na , Liu Enmei 
Published: April 2023

AbstractHuman adenovirus type 7 (HAdV-7) can cause severe pneumonia and complications in children. However, the mechanism of pathogenesis and the genes involved remain largely unknown. We collected HAdV-7-infected and mock-infected A549 cells at 24, 48, and 72 hours postinfection (hpi) for RNA sequencing (RNA-Seq) and identified potential genes and functional pathways associated with HAdV-7 infection using weighted gene coexpression network analysis (WGCNA). Based on bioinformatics analysis, 12 coexpression modules were constructed by WGCNA, with the blue, tan, and brown modules significantly positively correlated with adenovirus infection at 24, 48, and 72 hpi, respectively. Functional enrichment analysis indicated that the blue module was mainly enriched in DNA replication and viral processes, the tan module was largely enriched in metabolic pathways and regulation of superoxide radical removal, and the brown module was predominantly enriched in regulation of cell death. qPCR was used to determine transcript abundance of some identified hub genes, and the results were consistent with those from RNA-Seq. Comprehensively analyzing hub genes and differentially expressed genes in the GSE68004 dataset, we identified SOCS3, OASL, ISG15, and IFIT1 as potential candidate genes for use as biomarkers or drug targets in HAdV-7 infection. We propose a multi-target inhibition of the interferon signaling mechanism to explain the association of HAdV-7 infection with the severity of clinical consequences. This study has allowed us to construct a framework of coexpression gene modules in A549 cells infected with HAdV-7, thus providing a basis for identifying potential genes and pathways involved in adenovirus infection and for investigating the pathogenesis of adenovirus-associated diseases.
Evaluation of the properties of a new super quick-setting (2 min) polyether impression material
Authors: Singer Lamia , Keilig Ludger , Fichte Michèle , Bourauel Christoph 
Published: April 2023

Abstract
Objectives
Although a new super-quick setting polyether impression material has been commercially recently introduced, its properties have not been yet reported. Thus, it was the aim of this study to assess the dimensional stability, tear strength, and elastic recovery of the new material and to compare it with another commonly used polyether and polyvinyl siloxane.

Materials and methods
A new super-quick set polyether, a regular set polyether and a polyvinylsiloxane (PVS) impression material have been used in the study. Dimensional changes were measured using a modified mold as per ISO 4823:2000 after 1 h and 7 days. Tear strength was evaluated by subjecting specimens to tension until failure with a crosshead speed of 250 mm/min. Elastic recovery was measured by deforming specimens using a materials testing machine to a height of 16 mm (20% strain). The change in length (ΔL) was measured afterwards and elastic recovery was calculated in percentages.

Results
Dimensional changes of the super quick and regular set polyether were comparable in both the vertical and horizontal dimensions after 24 h and 7 days. All the tested materials showed dimensional change values far below the maximum accepted ISO requirement (1.5%). The super quick setting polyether showed significantly improved tear strength (4.9 N/mm) in comparison to the regular set polyether (3.5 N/mm) and similar to PVS (5.2 N/mm). The elastic recovery of PVS (99.6%) was the highest among all the groups.

Conclusions and clinical relevance
The newly available super-fast set polyether offers a great potential for a reduced chair side time and comfort for both, the patient and the dentist. Super quick polyether showed as well improved tear strength, which is considered one of the shortcomings of the regular set polyether. In addition, the new polyether was as accurate as the regular set polyether and with good elastic recovery.
Closure result for $$ \Gamma $$-limits of functionals with linear growth
Authors: Jesenko Martin 
Published: April 2023

AbstractWe consider integral functionals$$ \mathcal {F}^{(j)}_{\varepsilon } $$Fε(j), doubly indexed by$$ \varepsilon > 0 $$ε>0and$$j \in \mathbb N\cup \{ \infty \}$$j∈N∪{∞}, satisfying a standard linear growth condition. We investigate the question of$$ \Gamma $$Γ-closure, i.e., when the$$ \Gamma $$Γ-convergence of all families$$ \{ \mathcal {F}^{(j)}_{\varepsilon } \}_{\varepsilon }$${Fε(j)}εwith finitejimplies$$ \Gamma $$Γ-convergence of$$\{ \mathcal {F}^{(\infty )}_{\varepsilon } \}_{\varepsilon }$${Fε(∞)}ε. This has already been explored forp-growth with$$ p > 1 $$p>1. We show by an explicit counterexample that due to the differences between the spaces$$ W^{1,1} $$W1,1and$$ W^{1,p} $$W1,pwith$$ p > 1 $$p>1, an analog cannot hold. Moreover, we find a sufficient condition for a positive answer.
Network analysis of terms in the natural sciences insights from Wikipedia through natural language processing and network analysis
Authors: Wulff Peter 
Published: April 2023

AbstractScientists use specific terms to denote concepts, objects, phenomena, etc. The terms are then connected with each other in sentences that are used in science-specific language. Representing these connections through term networks can yield valuable insights into central terms and properties of the interconnections between them. Furthermore, understanding term networks can enhance assessment and diagnostics in science education. Computational means such as natural language processing and network analysis provide tools to analyze term networks in a principled way. This study utilizes natural language processing and network analysis to analyze linguistic properties of terms in the natural science disciplines (biology, chemistry, and physics). The language samples comprised German and English Wikipedia articles that are labelled according to the respective discipline. The different languages were used as contrasting cases. Natural language processing capabilities allowed us to extract term networks from the Wikipedia articles. The network analysis approach enabled us to gain insights into linguistic properties of science terms and interconnections among them. Our findings indicate that in German and English Wikipedia terms such as theory, time, energy, or system emerge as most central in physics. Moreover, the science-term networks display typical scale-free, complex systems behavior. These findings can enhance assessment of science learner’s language use. The tools of natural language processing and network analysis more generally can facilitate information extraction from language corpora in the education fields.
The status of the global food waste mitigation policies: experience and inspiration for China
Authors: Shen Guohui , Li Ziqi , Hong Tiannuo , Ru Xin , Wang Kunzhen , Gu Yanting , Han Juan , Guo Yanzhi 
Published: April 2023

AbstractFood waste has become a significant challenge faced by the community with a shared future for mankind, and it has also caused a considerable impact on China's food security. Scholars across disciplines, international organizations, and especially policymakers are increasingly interested in food waste. Policies are seen as a powerful factor in reducing food waste, but current research on related policies is more scattered. This paper summarizes and analyzes the experiences of food waste policy development and implementation by systematically reviewing the studies on food waste reduction policies. The results of this paper's analysis show that current global food waste policies are focused at the national strategic level, with approaches such as legislation, food donation, waste recycling, awareness and education, and data collection. At the same time, we find that the current experience of developed countries in policy formulation and implementation is beneficial for policy formulation in developing countries. And taking China as an example, we believe that developing countries can improve food waste policies in the future by improving legislation, guiding the development of food banks, promoting social governance, and strengthening scientific research projects. These policies will all contribute strongly to global environmental friendliness. In addition, we discuss some of the factors that influence the development of food waste policies and argue that in the future, more consideration needs to be given to the effects of policy implementation and that case studies should focus more on developing countries. This will contribute to the global sustainable development process.
Hepatic and cardiac implications of increased toxic amyloid-beta serum level in lipopolysaccharide-induced neuroinflammation in rats: new insights into alleviating therapeutic interventions
Authors: Anwar Mai M. , Mabrouk Abeer A. 
Published: April 2023

AbstractNeuroinflammation is a devastating predisposing factor for Alzheimer’s disease (AD). A number of clinical findings have reported peripheral disorders among AD patients. Amyloid beta (Aβ) is a toxic physiological aggregate that serves as a triggering factor for hepatic and cardiac disorders related to neurotoxicity. As a drawback of Aβ excessive accumulation in the brain, part of Aβ is believed to readily cross the blood–brain barrier (BBB) into the peripheral circulation resulting in serious inflammatory and toxic cascades acting as a direct bridge to cardiac and hepatic pathophysiology. The main aim is to find out whether neuroinflammation-related AD may result in cardiac and liver dysfunctions. Potential therapeutic interventions are also suggested to alleviate AD’s cardiac and hepatic defects. Male rats were divided into: control group I, lipopolysaccharide (LPS)-neuroinflammatory-induced group II, LPS-neuroinflammatory-induced group treated with sodium hydrogen sulphide donor (NaHS) (group III), and LPS-neuroinflammatory-induced group treated with mesenchymal stem cells (MSCs) (group IV). Behavior and histopathological studies were conducted in addition to the estimation of different biological biomarkers. It was revealed that the increased toxic Aβ level in blood resulted in cardiac and hepatic malfunctions as a drawback of exaggerated inflammatory cascades. The administration of NaHS and MSCs proved their efficiency in combating neuroinflammatory drawbacks by hindering cardiac and hepatic dysfunctions. The consistent direct association of decreased heart and liver functions with increased Aβ levels highlights the direct involvement of AD in other organ complications. Thereby, these findings will open new avenues for combating neuroinflammatory-related AD and long-term asymptomatic toxicity.Graphic abstract
Abiotic factors predict taxonomic composition and genetic admixture in populations of hybridizing white oak species (Quercus sect. Quercus) on regional scale
Authors: Reutimann Oliver , Dauphin Benjamin , Baltensweiler Andri , Gugerli Felix , Kremer Antoine , Rellstab Christian 
Published: April 2023

Abstract
Knowing which drivers affect the spatial distribution of hybridizing species and their admixed individuals on local or regional scale can leverage our understanding about processes that shape taxonomic diversity. Hybridizing white oak species (Quercus sect. Quercus) represent an ideal study system to elucidate which environmental factors determine their relative abundance and admixture levels within admixed forest stands. To elaborate these relationships, we used 58 species-diagnostic single-nucleotide polymorphism (SNP) markers and high-resolution topographic and soil data to identify the environmental factors associated with taxonomic composition of individuals and populations in 15 mixed stands of Q. petraea and Q. pubescens in the Valais, an inner-Alpine valley in Switzerland. At the individual tree level, generalized linear models (GLMs) explained a relatively small part of variation (R2 = 0.32). At the population level, GLMs often explained a large part of variation (R2 = 0.54–0.69) of the taxonomic indices. Mean taxonomic composition of the sites depended mainly on altitude and geographic position. Moreover, the more within-site variation we found in predictors related to topographic position, the higher was the average genetic admixture of single trees. Our results show that a multitude of topographic and edaphic factors affect the taxonomic composition and admixture levels of these two hybridizing oak species on local scale and that regional heterogeneity of these factors promote taxonomic diversity and admixture. Overall, our study highlights the prospects of using tailored genetic resources and high-resolution environmental data to understand and predict taxonomic composition in response to changing environments.
Integration (of Immigrants) in the European Courts’ Jurisprudence: Supporting a Pluralist and Rights-Based Paradigm?
Authors: Bottero Matteo 
Published: April 2023

AbstractThe concept of integration is the subject of various immigration policies but is still lacking a proper legal definition. In view of the abiding interest of the EU Member States to preserve their sovereignty over immigration, it is at serious risk of being instrumentalised for this purpose. Taking such circumstances into account, this article reflects on the model of integration resulting from the jurisprudence of the Court of Justice of the European Union and the European Court of Human Rights and questions the capacity of the two courts to advance a pluralist and rights-based paradigm of integration. On the one hand, it acknowledges the progressive enhancement of the protection of the immigrants’ fundamental and human rights. On the other hand, it points out the contradictions of a narrative that appears intrinsically incompatible with the very idea of pluralism by conceiving integration primarily as civic and cultural assimilation and placing most of the integration burden on the immigrants’ side.
Predicting bronze casting recipes in ancient China: ternary copper-lead–tin alloys and the “unit sum problem”
Authors: Pollard A. M. , Liu Ruiliang 
Published: April 2023

Abstract
This paper explores the relationship between trends in the observed composition of ternary copper-lead–tin alloys and the recreation of “recipes” used for the casting of bronze objects, and in particular, to ask if the recipe can be reconstructed from the chemical data. The archaeological context is specifically the manufacture of bronzes in pre-Dynastic China, but the nature of the discussion is essentially mathematical. Although the chemical compositions of Chinese bronzes have been well-studied and the casting processes have been exhaustively researched in terms of mould technology, little attention has been given to understanding the recipes used by the bronze casters when producing the alloy to pour into the moulds. The mathematical issue is simple—clearly, in a ternary alloy, the weight percentage compositions of the three components are intimately connected, such that if one goes up, the other two must reduce. Within this constraint, can the correlation patterns seen when assemblages of such objects are plotted as simple binary diagrams be interpreted in terms of the recipe used to create that alloy, and, in particular, can such recipes be replicated by simple numerical models?
Pattern of Facebook use by university students during the COVID-19 pandemic: relations with loneliness and resilience
Authors: Touloupis Thanos , Sofologi Maria , Tachmatzidis Dimitrios 
Published: April 2023

AbstractConsidering young adults’ extensive use of social media since the outbreak of the COVID-19 pandemic, the present study examined the pattern of Facebook use by university students during the period of hygienic crisis. Specifically, it was investigated students’ Facebook intensity use and self-disclosure to unknown online friends, as well as the role of sense of resilience and loneliness in the manifestation of the above Facebook behaviors. Overall, 792 undergraduate and postgraduate university students (48% women) completed online self-report questionnaires regarding the above variables. Undergraduate students, regardless of gender and Department of studies, made more intense Facebook use and self-disclosure to unknown online friends. Sense of loneliness positively predicted students’ online self-disclosure not only directly but also indirectly through their Facebook intensity use. Students’ resilience negatively moderated the relationship between sense of loneliness and Facebook behaviors. The findings propose a new explanatory model of emotional and behavioral mechanisms, which leads to a less safe pattern of Facebook use. This pattern possibly reflects youth’s collective tendency to use this social media platform recklessly as a way out of crisis periods, such as the pandemic period. The emergence of this pattern could be useful for launching or enriching university counselling/prevention actions aimed at strengthening students’ psycho-emotional skills, and subsequently their prudent use of social media.
Response surface optimization of a cardioprotective compound through pharmacosomal drug delivery system: in vivo bioavailability and cardioprotective activity potential
Authors: Dawoud Marwa H. S. , Zaafan Mai A. , Saleh Sarah S. , Mannaa Islam M. , Sweed Nabila M. 
Published: April 2023

AbstractVanillic acid (VA) is a phenolic compound with potential antioxidant activity, which improves ischemia-induced myocardial degeneration, by reducing oxidative stress; however, it suffers poor bioavailability owing to its poor solubility. VA-loaded pharmacosomes were optimized using a central composite design, where the effect of phosphatidylcholine:VA molar ratio and the precursor concentration were studied. An optimized formulation (O1) was prepared and tested for the release rate of VA, in vivo bioavailability, and cardioprotective potential on myocardial infarction-induced rats. The optimized formulation showed a particle size of 229.7 nm, polydispersity index of 0.29, and zeta potential of − 30 mV. O1 showed a sustained drug release for 48 h. The HPLC–UV method was developed for the determination of VA in plasma samples using protein precipitation. The optimized formulation showed a great improvement in the bioavailability as compared to VA. The residence time of the optimized formula was 3 times longer than VA. The optimized formulation showed a more potent cardioprotective effect as compared to VA, via inhibition of the MAPK pathway with subsequent inhibition of PI3k/NF-κB signaling, in addition to its antioxidant effect. The optimized formulation showed normalization of many oxidative stress and inflammatory biomarkers. Thus, a VA-loaded pharmacosome formulation with promising bioavailability and cardioprotective activity potential was prepared.
Graphical Abstract
Numerical studies to detect chaotic motion in the full planar averaged three-body problem
Authors: Di Ruzza Sara 
Published: April 2023

AbstractIn this paper, the author deals with a well-known problem of Celestial Mechanics, namely the three-body problem. A numerical analysis has been done in order to prove existence of chaotic motions of the full-averaged problem in particular configurations. Full because all the three bodies have non-negligible masses and averaged because the Hamiltonian describing the system has been averaged with respect to a fast angle. A reduction of degrees of freedom and of the phase-space is performed in order to apply the notion of covering relations and symbolic dynamics.
The Impact of Youth Digital Citizenship Education: Insights from a Cluster Randomized Controlled Trial Outcome Evaluation of the Be Internet Awesome (BIA) Curriculum
Authors: Jones Lisa M. , Mitchell Kimberly J. , Beseler Cheryl L. 
Published: April 2023

AbstractSchool psychologists and other school professionals are increasingly turning to digital citizenship programs to improve children’s online safety. However, to date, there has been no rigorous outcome evaluation of these programs. The current study used a cluster randomized control trial methodology (CRCT) to evaluate the impact of the Be Internet Awesome digital citizenship program on knowledge, attitudinal, and behavioral outcomes for 1072 4th–6th graders at 14 participating schools (7 treatment and 7 control schools). Multilevel logistic, multinomial, and Gaussian models were used to test outcomes. The study found support for program impact on children’s knowledge of new online safety concepts and self-efficacy for handling online problems relative to students in control conditions. However, no program impact was found for other outcomes including online privacy or civility, cyberbullying, and talking with parents about online problems. Findings highlight the need for clarity on digital citizenship program goals, innovative approaches, and increased evaluation research.