bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders
Authors: Bonifazi Alessandro , Del Bello Fabio , Giorgioni Gianfabio , Piergentili Alessandro , Saab Elizabeth , Botticelli Luca , Cifani Carlo , Micioni Di Bonaventura Emanuela , Micioni Di Bonaventura Maria Vittoria , Quaglia Wilma 
Published: April 2023

AbstractOrexin‐A and orexin‐B, also named hypocretin‐1 and hypocretin‐2, are two hypothalamic neuropeptides highly conserved across mammalian species. Their effects are mediated by two distinct G protein‐coupled receptors, namely orexin receptor type 1 (OX1‐R) and type 2 (OX2‐R), which share 64% amino acid identity. Given the wide expression of OX‐Rs in different central nervous system and peripheral areas and the several pathophysiological functions in which they are involved, including sleep‐wake cycle regulation (mainly mediated by OX2‐R), emotion, panic‐like behaviors, anxiety/stress, food intake, and energy homeostasis (mainly mediated by OX1‐R), both subtypes represent targets of interest for many structure–activity relationship (SAR) campaigns carried out by pharmaceutical companies and academies. However, before 2017 the research was predominantly directed towards dual‐orexin ligands, and limited chemotypes were investigated. Analytical characterizations, including resolved structures for both OX1‐R and OX2‐R in complex with agonists and antagonists, have improved the understanding of the molecular basis of receptor recognition and are assets for medicinal chemists in the design of subtype‐selective ligands. This review is focused on the medicinal chemistry aspects of small molecules acting as dual or subtype selective OX1‐R/OX2‐R agonists and antagonists belonging to different chemotypes and developed in the last years, including radiolabeled OX‐R ligands for molecular imaging. Moreover, the pharmacological effects of the most studied ligands in different neuropsychiatric diseases, such as sleep, mood, substance use, and eating disorders, as well as pain, have been discussed. Poly‐pharmacology applications and multitarget ligands have also been considered.
Comparison of free‐space VNA and TDS measurements using transmission‐type frequency selective surfaces
Authors: Kato Yuto , Kato Eiji 
Published: April 2023

AbstractA method for directly comparing vector network analyzer (VNA) and time‐domain spectrometer (TDS) measurements in free space using transmission‐type frequency selective surfaces (FSSs) is proposed. The transmission characteristics of FSSs with artificially controlled frequency dispersions facilitate flexible and detailed comparisons of VNA and TDS measurements. Four FSSs were designed as verification devices of free space measurements. The proposed approach was demonstrated in the D and J bands by comparing the measurement results of the transmission amplitude and phase characteristics of the FSSs obtained using VNA and TDS systems. The amplitude and phase results obtained using both systems were in good agreement, confirming the consistency and validity of the VNA and TDS measurements.
A filtering waveguide aperture antenna based on all‐resonator structures
Authors: Mahmud Rashad H. , Salih Idris H. , Shang Xiaobang , Skaik Talal , Wang Yi 
Published: April 2023

AbstractIn recent years, there has been a large amount of attention focused on the design of filtering antennas to reduce the front‐end size of modern wireless communication systems. Although numerous design approaches are presented in the literature, they are usually applicable to a certain microwave circuit structure. Additionally, their implementations demand extra matching circuits or a structure which leads to an increase in the filtering antenna size. In this paper, the design of a 3rd‐order filtering antenna operating at the X‐band frequencies is presented utilizing the coupling matrix approach. It is based on 3rd order coupled‐resonators filter without employing any extra structure. For the physical configuration, three inline coupled rectangular waveguide cavity resonators operating at TE101 mode are employed. The output of the last resonator is coupled to free space via a rectangular aperture. The dimensions of the aperture are manipulated to control the radiation quality factor (Qr). To validate the simulated results, the design has been fabricated using the Computer Numerical Control technique. Excellent agreement between the simulation and measurement results has been obtained. The fractional bandwidth (FBW) is more than 10% when the reflection coefficient S11 = −20 dB. The gain response is very flat (7.54 0.2 dBi) from 9.5 to 10.5 GHz. The proposed filtering antenna is compact and low profile which may be of interest in radar applications.
A broad axial ratio bandwidth and wide angle coverage circularly polarized monopole antenna for wireless communication
Authors: Barik Deepak K. , Mondal Kalyan , Azharuddin Mohd 
Published: April 2023

AbstractA uniquely shaped layout of a wideband circularly polarized (CP) printed monopole antenna is planned in this article. The proposed antenna comprises a 7‐shaped slotted radiating patch, tapered feed line, and modified partial ground plane. Multiple parasitic strips are employed at optimum positions on the ground and radiating planes to improve the axial ratio bandwidth (ARBW). The electrical dimension of the designed antenna is . The confirmed −10 dB impedance bandwidth (IBW) and 3 dB ARBW are 11.86 GHz (3.14–15 GHz), 130% and 6.32 GHz (4.04–10.36 GHz), 87.78% along with coverage angle. The proposed antenna is suitable for different applications in communication systems such as WLAN, WiMAX, FM CW altimeter, and satellite for C‐ and X‐ band.
The spectral‐voltage calibration technology of multispectral pyrometers based on Gauss–Newton‐genetic algorithm method for nonsource temperature regions
Authors: Xing Jian , Li Yaqi , Cui Shuanglong 
Published: April 2023

AbstractTo improve the accuracy of the nonsource temperature calibration method, a new method based on a Gauss–Newton‐genetic algorithm (GN‐GA) for the nonsource calibration of a multispectral pyrometer is proposed. Based on Planck's law, a temperature–voltage power function model was established based on constraint optimization, and the temperature–voltage function relationship of each spectral channel was obtained using a GN‐GA algorithm. When the GN‐GA algorithm extrapolated at 1000°C with 3000°C as the starting point, theoretical simulation results showed that, compared with the derivative least squares method, when the wavelengths were 0.4, 0.6, 0.8, and 1.0 μm, the extrapolation accuracy increased by 54.35%, 63.96%, 51.99%, and 44.05%, respectively. The black‐body experiment results showed that this method was feasible in multispectral, pyrometer, extrapolation, temperature–calibration technology. Compared with the results obtained by the derivative least squares method, the accuracy was improved for a given extrapolation temperature region, and the extrapolation interval was longer under the same accuracy.
Machine learning‐based automatic proton therapy planning: Impact of post‐processing and dose‐mimicking in plan robustness
Authors: Borderias‐Villarroel Elena , Huet Dastarac Margerie , Barragán‐Montero Ana María , Helander Rasmus , Holmstrom Mats , Geets Xavier , Sterpin Edmond 
Published: April 2023

AbstractPurposeAutomated treatment planning strategies are being widely implemented in clinical routines to reduce inter‐planner variability, speed up the optimization process, and improve plan quality. This study aims to evaluate the feasibility and quality of intensity‐modulated proton therapy (IMPT) plans generated with four different knowledge‐based planning (KBP) pipelines fully integrated into a commercial treatment planning system (TPS).Materials/MethodsA data set containing 60 oropharyngeal cancer patients was split into 11 folds, each containing 47 patients for training, five patients for validation, and five patients for testing. A dose prediction model was trained on each of the folds, resulting in a total of 11 models. Three patients were left out in order to assess if the differences introduced between models were significant. From voxel‐based dose predictions, we analyze the two steps that follow the dose prediction: post‐processing of the predicted dose and dose mimicking (DM). We focused on the effect of post‐processing (PP) or no post‐processing (NPP) combined with two different DM algorithms for optimization: the one available in the commercial TPS RayStation (RSM) and a simpler isodose‐based mimicking (IBM). Using 55 test patients (five test patients for each model), we evaluated the quality and robustness of the plans generated by the four proposed KBP pipelines (PP‐RSM, PP‐IBM, NPP‐RSM, NPP‐IBM). After robust evaluation, dose‐volume histogram (DVH) metrics in nominal and worst‐case scenarios were compared to those of the manually generated plans.ResultsNominal doses from the four KBP pipelines showed promising results achieving comparable target coverage and improved dose to organs at risk (OARs) compared to the manual plans. However, too optimistic post‐processing applied to the dose prediction (i.e. important decrease of the dose to the organs) compromised the robustness of the plans. Even though RSM seemed to partially compensate for the lack of robustness in the PP plans, still 65% of the patients did not achieve the expected robustness levels. NPP‐RSM plans seemed to achieve the best trade‐off between robustness and OAR sparing.Discussion/ConclusionsPP and DM strategies are crucial steps to generate acceptable robust and deliverable IMPT plans from ML‐predicted doses. Before the clinical implementation of any KBP pipeline, the PP and DM parameters predefined by the commercial TPS need to be modified accordingly with a comprehensive feedback loop in which the robustness of the final dose calculations is evaluated. With the right choice of PP and DM parameters, KBP strategies have the potential to generate IMPT plans within clinically acceptable levels comparable to plans manually generated by dosimetrists.
RF‐induced heating for active implantable medical devices in dual parallel leads configurations at 1.5 T MRI
Authors: Hu Wei , Guo Ran , Wang Qingyan , Zheng Jianfeng , Tsang Jeffrey , Kainz Wolfgang , Long Stuart , Chen Ji 
Published: April 2023

PurposeThe Radiofrequency (RF)‐induced heating for an active implantable medical device (AIMD) with dual parallel leads is evaluated in this paper. The coupling effects between dual parallel leads are studied via simulations and experiments methods. The global transfer function technique is used to assess the RF‐induced heating for dual‐lead AIMDs inside four human body models.MethodsRF‐induced heating for spinal cord stimulator systems with 60 and 90 cm length leads are studied at three parallel dual‐lead configurations (closely spaced, 8 mm spaced, and 40 mm spaced) and a single‐lead configuration. The global transfer function method is used to develop the AIMD models of different configurations and is used for lead‐tip heating assessments inside human body models.ResultsIn simulation studies, the peak 1g specific absorption rate/temperatrue rises of dual parallel leads systems is lower than those from the single‐lead system. In experimental American Society for Testing and Materials phantom studies, the temperature rises for the single‐lead AIMD system can be 2.4 times higher than that from dual‐lead AIMD systems. For the spinal cord stimulator systems used in the study, the statistical analysis shows the RF‐induced heating of dual‐lead configurations are also lower than those from the single‐lead configuration inside all four human body models.ConclusionFor the AIMD system in this study, it shows that the coupling effects between the dual parallel leads of AIMD systems can reduce RF‐induced heating. The global transfer function for different spatial distance dual‐lead configurations can potentially provide a method for the RF‐induced heating evaluation for dual‐lead AIMD systems.
Evaluation of the correlation between sleep quality and work engagement among nurses in Shanghai during the post‐epidemic era
Authors: Hui‐ren Zhuang , Li‐li Ma , Qin Liu , Wei‐ying Zhang , Hai‐ping Yu , Wei Zhao 
Published: April 2023

AbstractAimTo examine the status quo and influencing factors of sleep quality and work engagement of nurses participating in COVID‐19 during the post‐epidemic era and to study the relationship between them.DesignWe conducted a cross‐sectional survey and correlational and predictive logic to determine the association between sleep quality and work engagement among nurses in Shanghai during the post‐epidemic era.MethodsThis design involved 1060 frontline nurses in Shanghai. The Pittsburgh Sleep Quality Index questionnaire and the Utrecht Work Engagement Scale‐9 scales were used for data collection.ResultsThis study found that the sleep quality of frontline nurses was impaired and the nurses with poor sleep accounted for 48.20% during the post‐epidemic era. The work engagement of frontline nurses was at the medium level. Factors affecting nurses' sleep quality were the number of nurse night shifts, family support and nurse health. The factors affecting the nurse work engagement were monthly income, profession title, family support and self‐health status. There was a positive correlation between nurses' sleep quality and work engagement.
Growing beyond sickle cell disease: A metasynthesis of children, adolescents, and young adult experiences living with sickle cell disease
Authors: Coco Megan , Henderson Wendy A. , Park Crystal L. , Starkweather Angela R. 
Published: April 2023

AbstractChildren, adolescents, and young adults living with sickle cell disease (SCD) often experience an unpredictable and complex disease course. Although there is a growing literature on the lived experience of patients with SCD, qualitative syntheses are lacking. Therefore, a qualitative metasynthesis was conducted to inform care and potential interventions. Noblit and Hare's phases of metaethnographic research were used to guide the synthesis of qualitative data. Data extracted from the identified studies were directly compared through reciprocal translation. The 12 studies that met inclusion criteria for the meta‐synthesis included 177 participants ranging in age from 6 to 35 years old from six different countries. The authors identified three key metaphors: Ubiquitous Intrusion, Coping to Learn: Learning to Cope, and Part of the Whole. The metaphors were elucidated by three essential concepts that underlie the experience of children, adolescents, and young adults living with SCD: (1) recognition of SCD implications, (2) identifying ways to balance responsibilities, and (3) positioning oneself to thrive with SCD. The metaphors and essential concepts support the global theme of “Growing Beyond SCD.” The metasynthesis revealed the shared complexity of living with SCD among children, adolescents, and young adults from diverse cultures in which the yearning for a normal life drove learning to adapt and manage SCD with their support network. The key metaphors may be used to guide development of nursing interventions designed to promote self‐acceptance, coping, and adaptation skills among children, adolescents, and young adults that will help them to flourish while managing SCD as a chronic condition.
Differential deposition of bird body parts in domestic Viking Age middens in Iceland
Authors: Cesario Grace M. , Steinberg John M. 
Published: April 2023

AbstractZooarcheological analysis shows that there is an overabundance of seabird wings recovered from Viking Age archeological sites in Iceland, especially when the rest of the body is considered. Cultural choices seem to be driving this differential. By comparing two species of alcids to ptarmigan, primarily recovered from domestic middens, the overabundance of specific bones suggests differences in bird butchery and use strategies. The data come from nine sites: one from Þjórsárdalur, five from Skagafjörður, and three from Mývatnssveit. Alcid wings, particularly proximal bones, are disproportionately recovered, while ptarmigan are generally represented by more legs than expected. By several metrics, the statistical significance of these patterns is dramatic and leads to the conclusion that alcid wings are discarded more frequently than other body parts. The simplest explanation for this pattern is that it is a result of the availability of each of the birds, which ultimately affects the way they are processed.
Combined effects of nanoparticle and stretch‐induced orientation on crystal structure and properties of UHMWPE/TiO2 composite microporous membranes
Authors: Hu Tao , Mu Yue , Chen Yunqiang , Zhou Chengfan , Zhao Guoqun , Dong Guiwei 
Published: April 2023

AbstractThe nanocomposite microporous membrane of ultra‐high molecular weight polyethylene (UHMWPE) and nano‐titanium dioxide (nano‐TiO2) system was prepared by combining the thermally induced phase separation (TIPS) technique with the extrusion‐casting process using liquid paraffin (LP) as the diluent. The effects of variations of TiO2 content and melt draw ratio on the properties of composite microporous membranes were studied and the optimal processing parameters were further investigated. ATR‐FTIR demonstrated that nanocomposite microporous membranes were successfully prepared. The crystallization behavior and morphological evolution of membranes were systematically investigated by WAXD, 2D‐SAXS, and SEM. It was found that the stretch‐induced orientation of UHMWPE was promoted and the shish‐kebab structure was formed for the reason of addition of TiO2. The mechanism of combined effects of nanoparticles and stretch‐induced orientation on the crystallization behavior of UHMWPE was further discussed and explained. Compared to pure UHMWPE film, the permeability of the optimum performance film was significantly improved, with porosity of 49% and pure water flux of about 193 L m−2 h−1. Mechanical studies showed that nanoparticles and DR have significant effects on tensile strength and elongation at break. In addition, the thermal stability of composite microporous membranes was found to be improved with the increase of TiO2 content and melt draw ratio. Thus, this investigation delivers inspiration for the expansion of excellent performance microporous membranes used for battery separators and filtration devices.
Dielectric study of CoFe2O4/MWCNT/epoxy nanocomposites: Effect of temperature, concentration and irradiation
Authors: Meena Shivali , Kumari Neelam , Mitra Supratim , Singhal Rahul , Verma Sarika , Choubey Ravi Kant , Dwivedi Umesh Kumar 
Published: April 2023

AbstractIn this work, dielectric behavior of CoFe2O4/MWCNT/epoxy nanocomposites affected by concentration, temperature and Au ion irradiation is reported. The CoFe2O4 nanoparticles are synthesized via co‐precipitation technique. The samples of CoFe2O4/MWCNT/epoxy nanocomposites are prepared by varying ferrite contents (upto 50 phr). After that, the dielectric behavior is evaluated using LCR meter. The results exhibited that the dielectric constant of CoFe2O4/MWCNT/epoxy nanocomposites increases with increased ferrite content. The effect of temperature on dielectric of CoFe2O4/MWCNT/epoxy nanocomposites is observed at 27–100°C. The dielectric constant of prepared nanocomposites is gradually enhanced with elevation in temperature up to a certain value then decreased due to accumulation of charges at interfaces. Furthermore, reduced dielectric behavior of prepared nanocomposites can be seen on the account of ion irradiation effect.
Effects of ε‐polylysine or ε‐polylysine hydrochloride on the pH responsive ι‐carrageenan gel
Authors: Tian Jie , Wang Nan , Teng Wenxiu , Song Shuang , Pang Jie , Wu Chunhua , Wen Chengrong 
Published: April 2023

AbstractThe binding of oppositely charged polyelectrolytes is a well‐known gel strategy, and pH is an important factor affecting the gel properties. In this work, the influence of pH (3, 5, 7, 9, 11) on the rheological and textural properties, molecular structure and micromorphology of binary mixed gels of ι‐carrageenan (IC) and ε‐polylysine (PLL) or ε‐polylysine hydrochloride (PLH) was investigated. The results showed that a change in pH led to a change in the properties of binary mixed gels. The lower the pH, the higher were G′, G″, complex viscosity and gel transition temperature. At the same time, the water holding capacity and gel strength of IC/PLL (IP) and IC/PLH (IPH) were also improved accordingly, and the gel properties of IPH were always better than those of IP. As the pH increased to alkalinity, the density of the gel network structure decreased, the pore size decreased, the pore wall became thinner and the surface smoothed. When the pH dropped into the acidic range, there was a red shift of the hydroxyl group and the sulfate group bands, an enhancement of the hydrogen bonding interaction and a blue shift of the methyl band and the amide I band. At pH 3, the microscopic network structure of IP and IPH were dense and uniform with small pore size, rough surface and thick pore wall. These results showed that the binary mixed gels had better gel properties at pH 3. The results provided a theoretical basis for the preparation of IP and IPH gels, and also enabled a deeper understanding of the mechanism of interaction between polypeptides and carrageenan. © 2023 Society of Industrial Chemistry.
Impact of psychological monitors' interview about suicide on college students' negative emotion
Authors: Zhan Qisheng , Xia Tianyu , Zhang Lisha , Liu Yang 
Published: April 2023

AbstractThis study was to analyze the influence of psychological monitors (namely peer counselors with Chinese characteristics) and counselors on the affect of suicide‐related interviews among high‐risk students. 126 college students (Mage = 19.75 ± 1.05, aged: 18–23, 60% were male) were randomly divided into experimental group (interviewed) and control group (not interviewed). The experimental group filled in the positive and negative affect scale (PANAS) before and after the interview, while the experimental group and the control group filled in the Beck Hopelessness Scale (BHS) and Centre for Epidemiological Studies Depression Scale (CES‐D) before the interview and 1 week after the interview. The results showed that negative affect of the experimental group decreased more after the psychological counselor interviewed the experimental group than the psychological monitors. (short‐term effect: p = .001, Cohen's d = 0.66; long‐term depression: p = .007, ηp2 = 0.057) The interviewer's identity had no effect on the subjects' long‐term affect changes. (depression: F = 0.000, p = .987; hopelessness: F = 2.960, p = .09). Both psychological monitors and counselors can carry out suicide‐related interview for high‐risk students.