bluuebunny/crossref_metadata_2025_split huggingface dataset:
Widespread Increasing Ecosystem Water Limitation During the Past Three Decades in the Yellow River Basin, China
Authors: Zhao Fubo , Wang Xi , Ma Shuai , Wu Yiping , Qiu Linjing , Sun Pengcheng , Li Qiang 
Published: January 2023

AbstractTerrestrial ecosystems provide crucial ecosystem services to human beings, and their functions are largely dependent on soil moisture availability. Although many studies have evaluated the effects of vegetation and climate changes on soil moisture at the ecosystem scale, changes in ecosystem water limitation remain poorly understood. This study evaluated the spatiotemporal changes of ecosystem water limitation in the Yellow River Basin (YRB)—the second largest river basin of China—during 1982–2016 and identified the major drivers by establishing ecosystem limitation index (ELI) using soil moisture, transpiration, net radiation, and air temperature. The results show a significant and widespread spatiotemporal increase in the water limitation of ecosystems in YRB during the 35‐year study period. Temporally, areas with positive ELI (water‐limited regime) exhibited a significant upward trend (p < 0.01). Spatially, above 75.0% of the total areas showed an upward trend in ELI. Almost all ecosystems showed significant upward trends in water limitation over this period. Further analysis using two different but comparable methods, partial correlation and Lindeman‐Merenda‐Gold, show that vegetation change was the major driver of changes in water limitation, with contributions of more than 35.0%. Air temperature and atmospheric CO2 changes contributed comparably to changes in positive ELI, followed by precipitation changes. These findings improve the understanding of the spatiotemporal pattern and underlying mechanisms of ecosystem water limitation in the greening and warming YRB.
Efficacy and safety of perioperative application of ketamine on postoperative depression: A meta-analysis of randomized controlled studies
Authors: Guo Jie , Qiu Di , Gu Han-wen , Wang Xing-ming , Hashimoto Kenji , Zhang Guang-fen , Yang Jian-jun 
Published: January 2023

AbstractKetamine, a commonly used general anesthetic, can produce rapid and sustained antidepressant effect. However, the efficacy and safety of the perioperative application of ketamine on postoperative depression remains uncertain. We performed a meta-analysis to determine the effect of perioperative intravenous administration of ketamine on postoperative depression. Randomized controlled trials comparing ketamine with placebo in patients were included. Primary outcome was postoperative depression scores. Secondary outcomes included postoperative visual analog scale (VAS) scores for pain and adverse effects associated with ketamine. Fifteen studies with 1697 patients receiving ketamine and 1462 controls were enrolled. Compared with the controls, the ketamine group showed a reduction in postoperative depression scores, by a standardized mean difference (SMD) of −0.97, 95% confidence interval [CI, −1.27, −0.66], P < 0.001, I2 = 72% on postoperative day (POD) 1; SMD−0.65, 95% CI [−1.12, −0.17], P < 0.001, I2 = 94% on POD 3; SMD−0.30, 95% CI [−0.45, −0.14], P < 0.001, I2 = 0% on POD 7; and SMD−0.25, 95% CI [−0.38, −0.11], P < 0.001, I2 = 59% over the long term. Ketamine reduced VAS pain scores on POD 1 (SMD−0.93, 95% CI [−1.58, −0.29], P = 0.005, I2 = 97%), but no significant difference was found between the two groups on PODs 3 and 7 or over the long term. However, ketamine administration distinctly increased the risk of adverse effects, including nausea and vomiting (risk ratio [RR] 1.40, 95% CI [1.12, 1.75], P = 0.003, I2 = 30%), headache (RR 2.47, 95% CI [1.41, 4.32], P = 0.002, I2 = 19%), hallucination (RR 15.35, 95% CI [6.24, 37.34], P < 0.001, I2 = 89%), and dizziness (RR 3.48, 95% CI [2.68, 4.50], P < 0.001, I2 = 89%) compared with the controls. In conclusion, perioperative application of ketamine reduces postoperative depression and pain scores with increased risk of adverse effects.
Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1
Authors: Wei Keke , Zhang Huafeng , Yang Shuaishuai , Cui Yuxiao , Zhang Bingxia , Liu Jincheng , Tang Liang , Tan Yaoyao , Liu Simin , Chen Shiqi , Yuan Wu , Luo Xiao , Chen Chen , Li Fei , Liu Junwei , Chen Jie , Xu Pingwei , Lv Jiadi , Tang Ke , Zhang Yi , Ma Jingwei , Huang Bo 
Published: January 2023

AbstractMacrophages in tumors (tumor-associated macrophages, TAMs), a major population within most tumors, play key homeostatic functions by stimulating angiogenesis, enhancing tumor cell growth, and suppressing antitumor immunity. Resetting TAMs by simple, efficacious and safe approach(s) is highly desirable to enhance antitumor immunity and attenuate tumor cell malignancy. Previously, we used tumor cell-derived microparticles to package chemotherapeutic drugs (drug-MPs), which resulted in a significant treatment outcome in human malignant pleural effusions via neutrophil recruitments, implicating that drug-MPs might reset TAMs, considering the inhibitory effects of M2 macrophages on neutrophil recruitment and activation. Here, we show that drug-MPs can function as an antitumor immunomodulator by resetting TAMs with M1 phenotype and IFN-β release. Mechanistically, drug molecules in tumor MPs activate macrophage lysosomal P450 monooxygenases, resulting in superoxide anion formation, which further amplifies lysosomal ROS production and pH value by activating lysosomal NOX2. Consequently, lysosomal Ca2+ signaling is activated, thus polarizing macrophages towards M1. Meanwhile, the drug molecules are delivered from lysosomes into the nucleus where they activate DNA sensor hnRNPA2B1 for IFN-β production. This lysosomal-nuclear machinery fully arouses the antitumor activity of macrophages by targeting both lysosomal pH and the nuclear innate immunity. These findings highlight that drug-MPs can act as a new immunotherapeutic approach by revitalizing antitumor activity of macrophages. This mechanistic elucidation can be translated to treat malignant ascites by drug-MPs combined with PD-1 blockade.
Alternative splicing in multiple myeloma is associated with the non-homologous end joining pathway
Authors: Liu Enze , Becker Nathan , Sudha Parvathi , Dong Chuanpeng , Liu Yunlong , Keats Jonathan , Morgan Gareth , Walker Brian A. 
Published: January 2023

AbstractAlternative splicing plays a pivotal role in tumorigenesis and proliferation. However, its pattern and pathogenic role has not been systematically analyzed in multiple myeloma or its subtypes. Alternative splicing profiles for 598 newly diagnosed myeloma patients with comprehensive genomic annotation identified primary translocations, 1q amplification, and DIS3 events to have more differentially spliced events than those without. Splicing levels were correlated with expression of splicing factors. Moreover, the non-homologous end joining pathway was an independent factor that was highly associated with splicing frequency as well as an increased number of structural variants. We therefore identify an axis of high-risk disease encompassing expression of the non-homologous end joining pathway, increase structural variants, and increased alternative splicing that are linked together. This indicates a joint pathogenic role for DNA damage response and alternative RNA processing in myeloma.
Mineral weathering is linked to microbial priming in the critical zone
Authors: Fang Qian , Lu Anhuai , Hong Hanlie , Kuzyakov Yakov , Algeo Thomas J. , Zhao Lulu , Olshansky Yaniv , Moravec Bryan , Barrientes Danielle M. , Chorover Jon 
Published: January 2023

AbstractDecomposition of soil organic matter (SOM) can be stimulated by fresh organic matter input, a phenomenon known as the ‘priming effect’. Despite its global importance, the relationship of the priming effect to mineral weathering and nutrient release remains unclear. Here we show close linkages between mineral weathering in the critical zone and primed decomposition of SOM. Intensified mineral weathering and rock-derived nutrient release are generally coupled with primed SOM decomposition resulting from “triggered” microbial activity. Fluxes of organic matter products decomposed via priming are linearly correlated with weathering congruency. Weathering congruency influences the formation of organo-mineral associations, thereby modulating the accessibility of organic matter to microbial decomposers and, thus, the priming effect. Our study links weathering with primed SOM decomposition, which plays a key role in controlling soil C dynamics in space and time. These connections represent fundamental links between long-term lithogenic element cycling (= weathering) and rapid turnover of carbon and nutrients (= priming) in soil.
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
Authors: Inguanzo Anna , Poulakis Konstantinos , Mohanty Rosaleena , Schwarz Christopher G. , Przybelski Scott A. , Diaz-Galvan Patricia , Lowe Val J. , Boeve Bradley F. , Lemstra Afina W. , van de Beek Marleen , van der Flier Wiesje , Barkhof Frederik , Blanc Frederic , Loureiro de Sousa Paulo , Philippi Nathalie , Cretin Benjamin , Demuynck Catherine , Nedelska Zuzana , Hort Jakub , Segura Barbara , Junque Carme , Oppedal Ketil , Aarsland Dag , Westman Eric , Kantarci Kejal , Ferreira Daniel 
Published: January 2023

AbstractDementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.
Deep phenotyping and genomic data from a nationally representative study on dementia in India
Authors: Lee Jinkook , Petrosyan Sarah , Khobragade Pranali , Banerjee Joyita , Chien Sandy , Weerman Bas , Gross Alden , Hu Peifeng , Smith Jennifer A. , Zhao Wei , Aksman Leon , Jain Urvashi , Shanthi G. S. , Kurup Ravi , Raman Aruna , Chakrabarti Sankha Shubhra , Gambhir Indrajeet Singh , Varghese Mathew , John John P. , Joshi Himanshu , Koul Parvaiz A. , Goswami Debabrata , Talukdar Arunansu , Mohanty Rashmi Ranjan , Yadati Y. Sathyanarayana Raju , Padmaja Mekala , Sankhe Lalit , Rajguru Chhaya , Gupta Monica , Kumar Govind , Dhar Minakshi , Jovicich Jorge , Ganna Andrea , Ganguli Mary , Chatterjee Prasun , Singhal Sunny , Bansal Rishav , Bajpai Swati , Desai Gaurav , Bhatankar Swaroop , Rao Abhijith R. , Sivakumar Palanimuthu T. , Muliyala Krishna Prasad , Sinha Preeti , Loganathan Santosh , Meijer Erik , Angrisani Marco , Kim Jung Ki , Dey Sharmistha , Arokiasamy Perianayagam , Bloom David E. , Toga Arthur W. , Kardia Sharon L. R. , Langa Kenneth , Crimmins Eileen M. , Dey Aparajit B. 
Published: January 2023

AbstractThe Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study of cognitive aging and dementia. We present a publicly available dataset of harmonized cognitive measures of 4,096 adults 60 years of age and older in India, collected across 18 states and union territories. Blood samples were obtained to carry out whole blood and serum-based assays. Results are included in a venous blood specimen datafile that can be linked to the Harmonized LASI-DAD dataset. A global screening array of 960 LASI-DAD respondents is also publicly available for download, in addition to neuroimaging data on 137 LASI-DAD participants. Altogether, these datasets provide comprehensive information on older adults in India that allow researchers to further understand risk factors associated with cognitive impairment and dementia.
Constraints on cooperation shape hierarchical versus distributed structure in human groups
Authors: Zefferman Matthew R. 
Published: January 2023

AbstractSome human groups are organized hierarchically and some are distributed. Both types of groups occur in economic, political, and military domains, but it is unclear why hierarchical organizations are favored in certain contexts and distributed organizations are favored in others. I propose that these different organizational structures can be explained by human groups having different constraints on their ability to foster cooperation within the group. Human within-group cooperation is often maintained by monitoring and punishment. In hierarchical groups, monitoring and punishment are organized into tree-like command-and-control structures with supervisors responsible for monitoring the cooperation of their subordinates and punishing non-cooperators. By contrast, in distributed groups, monitoring is diffuse and punishment is collective. I propose that the organization of cooperative human groups is constrained by the costs of monitoring and punishment. I formalize this hypothesis with a model where individuals in a group cooperate to produce public goods while embedded in a network of monitoring and punishment responsibilities. I show that, when punishment costs are high and monitoring costs are low, socially-optimal monitoring and punishment networks are distributed. The size of these distributed networks is constrained by monitoring costs. However, when punishment costs are low, socially-optimal networks are hierarchical. Monitoring costs do not constrain the size of hierarchical networks but determine how many levels of supervision are required to foster cooperation in the hierarchical group. These results may explain the increasingly large and hierarchical groups throughout much of human history. They also suggest that the recent emergence of large-scale distributed organizations has been possible because new technologies, like the internet, have made monitoring costs extremely low.
The influence of task difficulty, social tolerance and model success on social learning in Barbary macaques
Authors: Garcia-Nisa Ivan , Evans Cara , Kendal Rachel L. 
Published: January 2023

AbstractDespite playing a pivotal role in the inception of animal culture studies, macaque social learning is surprisingly understudied. Social learning is important to survival and influenced by dominance and affiliation in social animals. Individuals generally rely on social learning when individual learning is costly, and selectively use social learning strategies influencing what is learned and from whom. Here, we combined social learning experiments, using extractive foraging tasks, with network-based diffusion analysis (using various social relationships) to investigate the transmission of social information in free-ranging Barbary macaques. We also investigated the influence of task difficulty on reliance on social information and evidence for social learning strategies. Social learning was detected for the most difficult tasks only, with huddling relations outside task introductions, and observation networks during task introductions, predicting social transmission. For the most difficult task only, individuals appeared to employ a social learning strategy of copying the most successful demonstrator observed. Results indicate that high social tolerance represents social learning opportunities and influences social learning processes. The reliance of Barbary macaques on social learning, and cues of model-success supports the costly information hypothesis. Our study provides more statistical evidence to the previous claims indicative of culture in macaques.
Nudibranch predation boosts sponge silicon cycling
Authors: López-Acosta María , Potel Clémence , Gallinari Morgane , Pérez Fiz F. , Leynaert Aude 
Published: January 2023

AbstractDiatoms play a key role in the marine silica cycle, but recent studies have shown that sponges can also have an important effect on this dynamic. They accumulate large stocks of biogenic silica within their bodies over long periods, which are thought to vary little on an intra-annual scale. The observation of an abrupt decline in sponge biomass in parallel with large increases in abundance of a spongivorous nudibranch (Doris verrucosa) led us to conduct a year-long study on the effect of nudibranch predation on the silicon budget of a sponge (Hymeniacidon perlevis) population. After 5 months of predation, the abundance of sponge individuals did not change but their biomass decreased by 95%, of which 48% was explained by nudibranch predation. About 97% of sponge spicules ingested by nudibranchs while feeding was excreted, most of them unbroken, implying a high rate of sponge silica deposition in the surrounding sediments. After predation, sponges partially recovered their biomass stocks within 7 months. This involved a rapid growth rate and large assimilation of dissolved silicon. Surprisingly, the highest rates of silicon absorption occurred when dissolved silicon concentration in seawater was minimal (< 1.5 µM). These findings suggest that the annual sponge predation-recovery cycle triggers unprecedented intra-annual changes in sponge silicon stocks and boosts the cycling of this nutrient. They also highlight the need for intra-annual data collection to understand the dynamics and resilience of sponge ecosystem functioning.
Prediction of pathologic complete response to neoadjuvant systemic therapy in triple negative breast cancer using deep learning on multiparametric MRI
Authors: Zhou Zijian , Adrada Beatriz E. , Candelaria Rosalind P. , Elshafeey Nabil A. , Boge Medine , Mohamed Rania M. , Pashapoor Sanaz , Sun Jia , Xu Zhan , Panthi Bikash , Son Jong Bum , Guirguis Mary S. , Patel Miral M. , Whitman Gary J. , Moseley Tanya W. , Scoggins Marion E. , White Jason B. , Litton Jennifer K. , Valero Vicente , Hunt Kelly K. , Tripathy Debu , Yang Wei , Wei Peng , Yam Clinton , Pagel Mark D. , Rauch Gaiane M. , Ma Jingfei 
Published: January 2023

AbstractTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Neoadjuvant systemic therapy (NAST) followed by surgery are currently standard of care for TNBC with 50-60% of patients achieving pathologic complete response (pCR). We investigated ability of deep learning (DL) on dynamic contrast enhanced (DCE) MRI and diffusion weighted imaging acquired early during NAST to predict TNBC patients’ pCR status in the breast. During the development phase using the images of 130 TNBC patients, the DL model achieved areas under the receiver operating characteristic curves (AUCs) of 0.97 ± 0.04 and 0.82 ± 0.10 for the training and the validation, respectively. The model achieved an AUC of 0.86 ± 0.03 when evaluated in the independent testing group of 32 patients. In an additional prospective blinded testing group of 48 patients, the model achieved an AUC of 0.83 ± 0.02. These results demonstrated that DL based on multiparametric MRI can potentially differentiate TNBC patients with pCR or non-pCR in the breast early during NAST.
Sedentary behaviour and sleep quality
Authors: Koohsari Mohammad Javad , Yasunaga Akitomo , McCormack Gavin R. , Shibata Ai , Ishii Kaori , Liao Yung , Nagai Yukari , Oka Koichiro 
Published: January 2023

AbstractHigh-quality sleep is an important factor in sustaining health and improving well-being. Previous evidence has demonstrated the positive associations between increased physical activity and reduced sedentary behaviour (SB) with sleep quality. The substitutional relationships between SB, light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) need to be considered when examining how a particular behaviour may impact sleep quality. No studies, to our knowledge, have explored these substitutional relationships in middle-aged adulthood. Using an isotemporal substitution approach, this study examined the associations of replacing sedentary time with physical activity on sleep quality measures in a sample of middle-aged adults in Japan. Data from 683 adults aged 40–64 living in Japan were used. The average daily time spent in SB, LPA, and MVPA was objectively assessed by accelerometers. Two self-reported sleep quality measures were obtained using questionnaires, including rest by sleep and sleep quality. Multivariable linear regression models were used to assess the associations of SB, LPA, and MVPA with the sleep quality measures stratified by gender. We found that each 60 min unit of SB or LPA replaced with MVPA was favourably associated with rest by sleep among women (β = 0.16, 95% CI 0.07, 0.28, p < 0.001; β = 0.18, 95% CI 0.07, 0.32, p < 0.05, respectively). There were no significant associations between SB, LPA, and MVPA with sleep measures in men across all three models. These findings indicate that higher MVPA has a positive association with sleep quality in middle-aged women.
A high-throughput sequencing survey characterizing European foulbrood disease and Varroosis in honey bees
Authors: Anderson Kirk E. , Copeland Duan C. , Erickson Robert J. , Floyd Amy S. , Maes Patrick C. , Mott Brendon M. 
Published: January 2023

AbstractAs essential pollinators of ecosystems and agriculture, honey bees (Apis mellifera) are host to a variety of pathogens that result in colony loss. Two highly prevalent larval diseases are European foulbrood (EFB) attributed to the bacterium Melissococcus plutonius, and Varroosis wherein larvae can be afflicted by one or more paralytic viruses. Here we used high-throughput sequencing and qPCR to detail microbial succession of larval development from six diseased, and one disease-free apiary. The disease-free larval microbiome revealed a variety of disease-associated bacteria in early larval instars, but later developmental stages were dominated by beneficial symbionts. Microbial succession associated with EFB pathology differed by apiary, characterized by associations with various gram-positive bacteria. At one apiary, diseased larvae were uniquely described as “melting and deflated”, symptoms associated with Varroosis. We found that Acute Bee Paralysis Virus (ABPV) levels were significantly associated with these symptoms, and various gram-negative bacteria became opportunistic in the guts of ABPV afflicted larvae. Perhaps contributing to disease progression, the ABPV associated microbiome was significantly depleted of gram-positive bacteria, a likely result of recent antibiotic application. Our results contribute to the understanding of brood disease diagnosis and treatment, a growing problem for beekeeping and agriculture worldwide.