bluuebunny/crossref_metadata_2025_split huggingface dataset:
UN-PUNet for phase unwrapping from a single uneven and noisy ESPI phase pattern
Authors: He Hongxuan , Tang Chen , Zhang Liao , Xu Min , Lei Zhenkun 
Published: September 2023

The wrapped phase patterns of objects with varying materials exhibit uneven gray values. Phase unwrapping is a tricky problem from a single wrapped phase pattern in electronic speckle pattern interferometry (ESPI) due to the gray unevenness and noise. In this paper, we propose a convolutional neural network (CNN) model named UN-PUNet for phase unwrapping from a single wrapped phase pattern with uneven grayscale and noise. UN-PUNet leverages the benefits of a dual-branch encoder structure, a multi-scale feature fusion structure, a convolutional block attention module, and skip connections. Additionally, we have created an abundant dataset for phase unwrapping with varying degrees of unevenness, fringe density, and noise levels. We also propose a mixed loss function MS_SSIM + L2. Employing the proposed dataset and loss function, we can successfully train the UN-PUNet, ultimately realizing effective and robust phase unwrapping from a single uneven and noisy wrapped phase pattern. We evaluate the performance of our method on both simulated and experimental ESPI wrapped phase patterns, comparing it with DLPU, VUR-Net, and PU-M-Net. The unwrapping performance is assessed quantitatively and qualitatively. Furthermore, we conduct ablation experiments to evaluate the impact of different loss functions and the attention module utilized in our method. The results demonstrate that our proposed method outperforms the compared methods, eliminating the need for pre-processing, post-processing procedures, and parameter fine-tuning. Moreover, our method effectively solves the phase unwrapping problem while preserving the structure and shape, eliminating speckle noise, and addressing uneven grayscale.
The impact of heating, ventilation, and air conditioning design features on the transmission of viruses, including the 2019 novel coronavirus: A systematic review of filtration
Authors: Thornton Gail M. , Fleck Brian A. , Kroeker Emily , Dandnayak Dhyey , Fleck Natalie , Zhong Lexuan , Hartling Lisa 
Published: September 2023

Historically, viruses have demonstrated airborne transmission. Emerging evidence suggests the novel coronavirus (SARS-CoV-2) that causes COVID-19 also spreads by airborne transmission. This is more likely in indoor environments, particularly with poor ventilation. In the context of airborne transmission, a vital mitigation strategy for the built environment is heating, ventilation, and air conditioning (HVAC) systems. HVAC features could modify virus transmission potential. A systematic review was conducted to identify and synthesize research examining the effectiveness of filters within HVAC systems in reducing virus transmission. A comprehensive search of OVID MEDLINE, Compendex, and Web of Science Core was conducted to January 2021. Two authors were involved in study selection, data extraction, and risk of bias assessments. Study characteristics and results were displayed in evidence tables and findings were synthesized narratively. Twenty-three relevant studies showed that: filtration was associated with decreased transmission; filters removed viruses from the air; increasing filter efficiency (efficiency of particle removal) was associated with decreased transmission, decreased infection risk, and increased viral filtration efficiency (efficiency of virus removal); increasing filter efficiency above MERV 13 was associated with limited benefit in further reduction of virus concentration and infection risk; and filters with the same efficiency rating from different companies showed variable performance. Adapting HVAC systems to mitigate virus transmission requires a multi-factorial approach and filtration is one factor offering demonstrated potential for decreased transmission. For filtration to be effective, proper installation is required. Of note, similarly rated filters from different companies may offer different virus reduction results. While increasing filtration efficiency (i.e., increasing MERV rating or moving from MERV to HEPA) is associated with virus mitigation, there are diminishing returns for filters rated MERV 13 or higher. Although costs increase with filtration efficiency, they are lower than the cost of ventilation options with the equivalent reduction in transmission.Systematic review registration: PROSPERO 2020CRD42020193968.
Androgen receptor and its correlation with estrogen and progesterone receptors, aimed for identification of cases for future anti-androgen therapy in endometrial cancers
Authors: Moatamed Neda A. , Vahdatshariatpanahi Saba , Gjertson David W. , Sachs Chana R. , Kang Yuna , Ostrzega Nora , Huang Jiaoti , Memarzadeh Sanaz 
Published: September 2023

Introduction
The expression of androgen receptor (AR) is not commonly tested or studied in uterine cancers, unlike estrogen receptor (ER) and progesterone receptor (PR) which are positive in most endometrial carcinomas. In this series, we evaluated the expression of AR and its comparison to ER and PR in different types of endometrial cancers and have reviewed the literature.

Materials and methods
The status of AR, ER, and PR expression were evaluated in 71 cases which were categorized into endometrial endometrioid cancer (EEC), non-endometrioid endometrial cancers (NEEC), and metastatic carcinomas of endometrium. Expression of the receptors were compared to each other as well as to mismatch repair proteins (MMR), p53, and body mass index (BMI) using Fisher’s Exact test in the StatPlus software.

Results
In EECs, the positivity was 97% for all the three receptors. In NEEC, positivity rates were 68%, 48%, and 35% for AR, ER, and PR respectively. In Metastatic carcinomas, AR and ER positivity was seen in 100% while PR was positive in 75% of the cases. In all cancers, the rates were 17% (11/66) for MMR loss, 57% (30/53) for p53 aberrant expression, and 76% (54/71) for the patients with BMI of ≥ 25 (kg/m2).

Conclusion
AR is expressed in a high percentage of endometrial cancers. Its significance is more evident in high-grade NEEC where ER and PR may not be expressed. These findings warrant further evaluation of AR expression and candidacy of this pathway as a potential therapeutic target in endometrial cancers.
Protocol for a randomized controlled trial to evaluate a year-long (NICU-to-home) evidence-based, high dose physical therapy intervention in infants at risk of neuromotor delay
Authors: Deng Weiyang , Anastasopoulos Sofia , deRegnier Raye-Ann , Pouppirt Nicole , Barlow Ann K. , Patrick Cheryl , O’Brien Megan K. , Babula Sarah , Sukal-Moulton Theresa , Peyton Colleen , Morgan Catherine , Rogers John A. , Lieber Richard L. , Jayaraman Arun 
Published: September 2023

Introduction
Developmental disabilities and neuromotor delay adversely affect long-term neuromuscular function and quality of life. Current evidence suggests that early therapeutic intervention reduces the severity of motor delay by harnessing neuroplastic potential during infancy. To date, most early therapeutic intervention trials are of limited duration and do not begin soon after birth and thus do not take full advantage of early neuroplasticity. The Corbett Ryan–Northwestern–Shirley Ryan AbilityLab–Lurie Children’s Infant Early Detection, Intervention and Prevention Project (Project Corbett Ryan) is a multi-site longitudinal randomized controlled trial to evaluate the efficacy of an evidence-based physical therapy intervention initiated in the neonatal intensive care unit (NICU) and continuing to 12 months of age (corrected when applicable). The study integrates five key principles: active learning, environmental enrichment, caregiver engagement, a strengths-based approach, and high dosage (ClinicalTrials.gov identifier NCT05568264).

Methods
We will recruit 192 infants at risk for neuromotor delay who were admitted to the NICU. Infants will be randomized to either a standard-of-care group or an intervention group; infants in both groups will have access to standard-of-care services. The intervention is initiated in the NICU and continues in the infant’s home until 12 months of age. Participants will receive twice-weekly physical therapy sessions and caregiver-guided daily activities, assigned by the therapist, targeting collaboratively identified goals. We will use various standardized clinical assessments (General Movement Assessment; Bayley Scales of Infant and Toddler Development, 4th Edition (Bayley-4); Test of Infant Motor Performance; Pediatric Quality of Life Inventory Family Impact Module; Alberta Infant Motor Scale; Neurological, Sensory, Motor, Developmental Assessment; Hammersmith Infant Neurological Examination) as well as novel technology-based tools (wearable sensors, video-based pose estimation) to evaluate neuromotor status and development throughout the course of the study. The primary outcome is the Bayley-4 motor score at 12 months; we will compare scores in infants receiving the intervention vs. standard-of-care therapy.
Trends in U.S. self-reported health and self-care behaviors during the COVID-19 pandemic
Authors: Hooper Madison , Reinhart Morgan , Dusetzina Stacie B. , Walsh Colin , Griffith Kevin N. 
Published: September 2023

Importance
The COVID-19 pandemic represents a unique stressor in Americans’ daily lives and access to health services. However, it remains unclear how the pandemic impacted perceived health status and engagement in health-related behaviors.

Objective
To assess changes in self-reported health outcomes during the COVID-19 pandemic, and to explore trends in health-related behaviors that may underlie the observed health changes.

Design
Interrupted time series stratified by age, gender, race/ethnicity, educational attainment, household income, and employment status.

Setting
United States.

Participants
All adult respondents to the 2016–2020 Behavioral Risk Factor Surveillance System (N = 2,146,384).

Exposure
Survey completion following the U.S. public health emergency declaration (March-December 2020). January 2019 to February 2020 served as our reference period.

Main outcomes and measures
Self-reported health outcomes included the number of days per month that respondents spent in poor mental health, physical health, or when poor health prevented their usual activities of daily living. Self-reported health behaviors included the number of hours slept per day, number of days in the past month where alcohol was consumed, participation in any exercise, and current smoking status.

Results
The national rate of days spent in poor physical health decreased overall (-1.00 days, 95% CI: -1.10 to -0.90) and for all analyzed subgroups. The rate of poor mental health days or days when poor health prevented usual activities did not change overall but exhibited substantial heterogeneity by subgroup. We also observed overall increases in mean sleep hours per day (+0.09, 95% CI 0.05 to 0.13), the percentage of adults who report any exercise activity (+3.28%, 95% CI 2.48 to 4.09), increased alcohol consumption days (0.27, 95% CI 0.18 to 0.37), and decreased smoking prevalence (-1.11%, 95% CI -1.39 to -0.83).

Conclusions and relevance
The COVID-19 pandemic had deleterious but heterogeneous effects on mental health, days when poor health prevented usual activities, and alcohol consumption. In contrast, the pandemic’s onset was associated with improvements in physical health, mean hours of sleep per day, exercise participation, and smoking status. These findings highlight the need for targeted outreach and interventions to improve mental health in individuals who may be disproportionately affected by the pandemic.
Effects of non-technical skill-based surgical education for trainees on herniorrhaphy outcomes
Authors: Koike Daisuke , Nishimura Takahiro , Suka Yusuke , Nagai Motoki , Nomura Yukihiro , Kato Hiroyuki , Asano Yukio , Ito Masahiro , Arakawa Satoshi , Ishihara Takuma , Horiguchi Akihiko 
Published: September 2023

Introduction
Non-technical skills are essential for surgical patient safety and are implemented in clinical practice. However, training for non-technical skills has not been thoroughly investigated. This study aimed to evaluate the learning curve for non-technical skill-based education in herniorrhaphy.

Methods
Quality improvement initiatives, including non-technical skill-based intervention, were performed in the department of surgery. The intervention included declaring the patient safety policy, briefing and debriefing, and criterion for the switching of places of the trainee and instructor as defined by the department. Patients who underwent herniorrhaphy from April 2014 to September 2017 were included.

Results
A total of 14 trainees and nine instructors in the pre-intervention period and 14 trainees and seven instructors in the intervention period were included in this study. The median experience of each trainee was 28 and 15 cases in the pre-intervention and intervention groups, respectively. A total of 749 patients were included: 473 in the pre-intervention period and 328 in the intervention period. Demographics and hernia types were mostly similar between groups, and morbidity was not statistically different between the two groups (3.4 vs. 1.2%, p = 0.054). The nonlinear regression model showed an early decline and deep plateau phase of the learning curve in the intervention group. A significant difference was observed in the plateau operation time (61 min in the pre-intervention group and 52 min in the intervention group).

Conclusion
This study demonstrated the effectiveness of non-technical skill-based intervention for surgical training. An early decline and deep plateau of the learning curve can be achieved with well-implemented quality improvement initiatives. Nonetheless, further studies are needed to establish a training program for non-technical skill-based learning.
Efficacy of nonpharmacological interventions targeting social function in children and adults with autism spectrum disorder: A systematic review and meta-analysis
Authors: Yu Zhili , Zhang Peiming , Tao Chenyang , Lu Liming , Tang Chunzhi 
Published: September 2023

Background and aims
This paper aimed to evaluate the use of nonpharmacological interventions for the management of autism spectrum disorder (ASD). The effects of acupuncture and behavioural therapy, two nonpharmalogical interventions, on social function in ASD patients are still controversial. This meta-analysis investigated the impact of these two treatments and compared their effects.

Methods
Seven electronic databases were systematically searched to identify randomized controlled trials (RCTs) on the use of acupuncture or behavioural therapy for ASD. A meta-analysis was carried out using Review Manager 5.4 software. Continuous data are reported as mean differences (MDs) or standardized mean differences (SMDs) with 95% confidence intervals (CIs). An assessment of methodological quality using the Cochrane risk-of-bias (ROB) tool for trials was carried out. The Grading of Recommendation Assessment, Development, and Evaluation (GRADE) was applied to evaluate the quality (certainty) of evidence for results regarding social function indicators.

Results
Thirty RCTs on acupuncture and 36 on behavioural therapy were included. Compared with the control condition, body acupuncture (SMD: 0.76, 95% CI: [0.52, 1.01]; low certainty), modern acupuncture technology (SMD: 0.84, 95% CI: [0.32, 1.35]; low certainty), cognitive behavioural therapy (SMD: 0.42, 95% CI: [0.26, 0.58]; high certainty), the Denver model (SMD: 0.61, 95% CI: [0.23, 0.99]; moderate certainty) and social skills training (SMD: 0.56, 95% CI: [0.41, 0.71]; moderate certainty) improved social functioning.

Conclusion
Behavioural therapies (such as CBT, the Denver model, social skills training), improved the social functioning of patients with ASD in the short and long term, as supported by high- and moderate-quality evidence. Acupuncture (including scalp acupuncture, body acupuncture and use of modern acupuncture technology) also improved social functioning, as supported by low- and very low-quality evidence. More high-quality evidence is needed to confirm the effect of acupoint catgut embedding and Early Intensive Behavioural Intervention (EIBI).
Gee Vaucher: Beyond Punk, Feminism and the Avant-Garde, Rebecca Binns (2022)
Authors: Owens Emily 
Published: September 2023

Review of: Gee Vaucher: Beyond Punk, Feminism and the Avant-Garde, Rebecca Binns (2022)
Manchester: Manchester University Press, 216 pp.,
ISBN 978-1-52614-789-9, p/bk, £20
Knockdown of DLK4 inhibits non-small cell lung cancer tumor growth by downregulating CKS2
Authors: Wan Zongren , Wang Jipeng , Liu Qing , Yang Dan , Li Pengling , Wang Lixin 
Published: September 2023

Abstract
Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases and is considered as the most common type of cancer. DLX4 was originally identified as a β-globin gene suppressor in red blood cells, which plays critical roles in several types of cancers. However, the role and related mechanism of DLX4 in NSCLC are still unclear. The study aimed to uncover the expression of DLX4 in human NSCLC cells and tissues, reveal its possible role in NSCLC, and investigate the underlying mechanisms. Immunoblot and TCGA database were used to detect the expression of DLX4 in human NSCLC cells and tissues. CCK-8, colony formation, and FCM assays were conducted to detect the effects of DLX4 on the viability and cell cycle of NCI-H2170 and A549 cells. Immunoblot assays were further performed to investigate the possible mechanism underlying DLX4 affecting the growth of NSCLC. We revealed that knockdown of DLX4 inhibited NSCLC cell proliferation. We further revealed that DLX4 knockdown induced the NSCLC cell cycle arrest. Our results further showed that downregulation of DLX4 suppressed YB-1 expression, which further suppressed CKS2 expression, thereby suppressing tumor growth of NSCLC. In conclusion, DLX4 has the potential to serve as a promising drug for NSCLC treatment.
Assessing the dimensionality of Chinese as a second language reading: a confirmatory factor analysis approach
Authors: Lin Jia 
Published: September 2023

Abstract
Second language (L2) reading is a complex construct, and there is no consensus about its dimensionality. The investigation of the dimensionality of L2 reading ability is of great significance since it can provide important implications for teaching and testing. Understanding of the factor structure, subskills, and sub-knowledge of L2 reading is the starting point for language teachers and test developers to plan a syllabus, describe students’ reading proficiency, and develop reading assessments. This study investigated the factor structure of Chinese L2 reading, which has been less commonly studied compared to alphabetic languages. Three hypotheses derived from the literature review have been tested: 1) L2 reading is a unitary skill; 2) L2 reading is bi-divisible; 3) L2 reading is tri-divisible. A series of confirmatory factor analyses shows that the correlated three-factor model is the most appropriate for explaining the factor structure. L2 Chinese reading comprehension can be conceptualized as consisting of three inter-correlated components: lower-level decoding, interim-level textbase construction, and higher-level situation-model building. This study also explores subcomponents of each factor, highlighting Chinese-specific linguistic features and corresponding cognitive processes. Implications for future research, teaching, and testing are provided.
Group trends and individual variability in writing development: a descriptive grammatical complexity analysis
Authors: Qin Wenjuan , Li Huixian , Zheng Yongyan 
Published: September 2023

AbstractThis study aims to examine group trends and individual variability of descriptive Grammatical Complexity (GC) in writing development. A longitudinal sample of 41 high school EFL learners is followed for an academic year (12 waves of data collection), resulting in a corpus of 492 texts, coded for eight descriptive GC features of academic writing. Our analysis reveals different sets of descriptive GC features relevant to capturing group trends and individual variability in writing development. At the group level, two phrasal-level GC features could capture significant changes in group means over time; at the individual level, four types of clausal and phrasal GC features showed significant associations between individual variability over time (measured by Standard Deviation of differences) and gains (as measured by the increase of usage frequency). Findings are discussed with regard to modeling both inter-individual and intra-individual trajectories in writing development and pedagogical implications attuned to both group and individual needs.
A different approach to the evaluation of the genotype-phenotype relationship in biotinidase deficiency: repeated measurement of biotinidase enzyme activity
Authors: Sürücü Kara İlknur , Köse Engin , Koç Yekedüz Merve , Eminoğlu Fatma Tuba 
Published: September 2023

Abstract

Objectives
In the present study, we aimed to evaluate the genotype-phenotype relation in patients with biotinidase enzyme deficiency based on repeated biotinidase enzyme measurements.

Methods
The hospital file information of patients with biotinidase, enzyme deficiency was assessed retrospectively, and the relationship between the BTD gene mutations analysis results and biotinidase enzyme activity following the first and repeated enzyme activity assessments was analyzed.

Results
One-hundred-ten patients were included. In the first enzyme evaluation, profound biotinidase enzyme deficiency was identified in 15 (13.6 %), partial biotinidase enzyme deficiency in 63 (57.3 %), and heterozygous biotinidase enzyme deficiency in 32 (29.1 %) of the patients. The BTD genetic analysis revealed 42 (38.2 %) homozygous, 42 (38.2 %) heterozygous, and 26 (23.6 %) compound heterozygous variants. The most common homozygous variant, p.Asp444His, was evaluated with 130 repeated enzyme measurements and was consistent with a partial biotinidase enzyme deficiency in 55.4 % of cases, heterozygous biotinidase enzyme deficiency in 43.8 % of cases, and profound biotinidase enzyme deficiency in one (0.8 %) case. Clinical symptoms developed in 17 patients during follow-up, of which 70.6 % were related to neurodevelopment. The most common variant was homozygous p.Asp444His (29.4 %) among the patients who developed symptoms.

Conclusions
This is the first study to date to evaluate the genotype-phenotype relationship in patients with biotinidase deficiency through repeated measurements of biotinidase enzyme activity. The study reveals that biotinidase enzyme activity alone is inadequate for diagnosing biotinidase enzyme deficiency or evaluating disease severity, as genetic investigations are also required for a definitive diagnosis of biotinidase enzyme deficiency.