bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre‐pandemic autonomic function as a predictor of the COVID clinical course in young adults
Authors: Sharma Vagisha , Pattnaik Sanghamitra , Ahluwalia Himani , Kaur Manpreet 
Published: May 2023

AbstractLong coronavirus disease (COVID) is emerging as a common clinical entity in the current era. Autonomic dysfunction is one of the frequently reported post‐COVID complications. We hypothesize a bi‐directional relationship between the autonomic function and the COVID course. This postulation has been inadequately addressed in the literature. A retrospective cohort (pre and post‐comparison) study was conducted on 30 young adults whose pre‐COVID autonomic function test results were available. They were divided into case and control groups based on whether they tested reverse transcription polymerase chain reaction positive for COVID‐19. Autonomic function tests were performed in both the case and control groups. COVID infection in healthy young adults shifts the sympatho–vagal balance from the pre‐disease state. Postural orthostatic tachycardia syndrome was present in 35% of the COVID‐affected group. COVID course parameters were found to be associated with parasympathetic reactivity and the baroreflex function. Baseline autonomic function (parasympathetic reactivity represented by Δ heart rate changes during deep breathing and 30:15 ratio during lying‐to‐standing test) was also associated with the COVID course, the post‐COVID symptoms and the post‐COVID autonomic function profile. Additionally, multiple regression analysis found that the baseline parasympathetic reactivity was a very important determinant of the clinical course of COVID, the post‐COVID symptoms and the post‐COVID autonomic profile. Sympatho–vagal balance shifts to parasympathetic withdrawal with sympathetic predominance due to COVID infection in healthy young adults. There is a bi‐directional relationship between the autonomic function and the COVID course.
Women and the Labour Party: Gender and the Writing of British Political History
Authors: Jenkins Lyndsey , Ward Stephanie 
Published: May 2023

AbstractThis article takes stock of the state of women's political history in the twentieth century and suggests new lines of enquiry, drawing on the authors’ own work on the Labour Party. It identifies a number of key themes which have enriched histories of women and gender in the nineteenth and early twentieth century and considers how these might be developed. Firstly, it examines the significance of the local, and more particularly, the neighbourhood, in women's political lives. Secondly, it asserts the value of focussing on the membership, including the economic, social and cultural shifts that shaped their lives, the intersection of gender with factors such as age or ethnicity, and their own political identities. Finally, it stresses the importance of interrogating masculine cultures to understand how gendered dynamics played out. It concludes with a reminder that inserting women into established political narratives is insufficient: the point is to transform those narratives.
Effects of activated earth, activated alumina, and chitosan adsorption processes on thermal and rheological and chemical characteristics of menhaden oil
Authors: Yin Huaixia , Bechtel Peter. J. , Sathivel Subramaniam 
Published: May 2023

AbstractThe objective of this study was the effectiveness of using activated earth, activated alumina, and/or chitosan, either separately or in combination, as adsorbents to remove free fatty acids (FFA) and peroxides from unpurified menhaden oil (MO). Thermal and rheological properties of MO were also evaluated. Five different combinations of absorbents were used to purify MO: Processes 1–3 involved purifications of MO by 5% chitosan (wt/wt of oil), 5% activated earth, and 5% activated alumina, respectively, process 4 involved MO purification with a combination of 6.5% chitosan, 3.5% activated earth, and 5% activated alumina, and process 5 involved MO purification process with a combination of adsorbents of 9% chitosan, 1% activated earth, and 5% activated alumina. All the adsorption processes were conducted at 25°C. Purified MO and MO were evaluated for their fatty acid profile, FFA, peroxide value (PV), moisture content (MC), minerals, and color. Triplicate experiments were conducted, and data were statistically analyzed using α = 0.05. Processes 4 and 5 were effective in reducing PV, FFA, and MC in MO. Thermal properties indicated processes 4 and 5 produced purer MO than processes 1–3. All the oil samples became less viscous, and the flow behavior index of MO was close to 1 after the adsorption processes. This study demonstrated that adsorption processes that include chitosan, activated earth, and activated alumina could effectively improve MO quality.
Enhancing perspectives on lake impairments using satellite observations: A case study on High Rock Lake, North Carolina
Authors: Di Vittorio Courtney A. , Moerk Michael , Kreutzberger William 
Published: May 2023

AbstractStakeholders developing water quality improvement plans for lakes and reservoirs are challenged by the sparsity of in‐situ data and the uncertainty ingrained in management decisions. This study explores how satellite images can fill gaps in water quality databases and provide more holistic assessments of impairments. The study site is an impaired water body that is serving as a pilot for improving state‐wide nutrient management planning processes. An existing in‐situ database was used to calibrate semi‐analytical models that relate satellite reflectance values to turbidity and total suspended solids (TSS). Landsat‐7 images from 1999 to 2020 that overpass High Rock Lake, North Carolina were downloaded and processed, providing 42 turbidity and 39 TSS satellite and in‐situ match‐ups for model calibration and validation. Model r‐squared values for the fitted turbidity and TSS models are 0.72 and 0.74, and the mean absolute errors are 14.6 NTU and 3.2 mg/L. The satellite estimates were compared to the in‐situ data and simulated TSS values produced by a calibrated hydrologic‐hydrodynamic model. The process‐based model is considered less accurate than the satellite model based on statistical performance metrics. Comparisons between data sources are illustrated with time series plots, frequency curves, and aggregate decision metrics to highlight the dependence of lake impairment assessments on the spatial and temporal frequency of available data and model accuracy.
Sequence capture: Obsolete or irreplaceable? A thorough validation across phylogenetic distances and its applicability to hybrids and allopolyploids
Authors: Bartoš Oldřich , Bohlen Jörg , Šlechtová Vendula Bohlen , Kočí Jan , Röslein Jan , Janko Karel 
Published: May 2023

AbstractAs whole‐genome sequencing has become pervasive, some have suggested that reduced genomic representation approaches, for example, sequence capture, are becoming obsolete. In the present study, we argue that these techniques still provide excellent tools in terms of price and quality of data as well as in their ability to provide markers with specific features, as required, for example, in phylogenomics. A potential drawback of the wide‐scale application of reduced representation approaches could be their drop in efficiency with increasing phylogenetic distance from the reference species. While some studies have focused on the degree and performance of reduced representation techniques in such situations, to our knowledge, none of them evaluated their applicability to inter‐specific hybrids and polyploids. This highlights a significant gap in current knowledge since there is increasing evidence for the frequent occurrence of natural hybrids and polyploids, as well as for the major importance of both phenomena in evolution. The main aim of the present study was to carry out a thorough validation of SEQcap applicability to (1) a set of non‐model taxa with a wide range of phylogenetic relatedness and (2) inter‐specific hybrids of various ploidies and genomic compositions. Considering the latter point, we especially focused on mechanisms causing allelic bias and consequent allelic dropout, as these could have confounding effects with respect to the evolutionary genomic dynamics of hybrids, especially in asexuals, which virtually reproduce as a frozen F1 generation.
Burial offerings in intramural tombs at Middle Bronze Age Megiddo
Authors: Amir Ayala , Kalisher Rachel , Cradic Melissa S. , Adams Matthew J. , Martin Mario A. S. , Neumann Ronny , Gadot Yuval , Finkelstein Israel 
Published: May 2023

AbstractTel Megiddo is a major type‐site for the Middle Bronze in the Levant. During this period a new burial custom appeared in which the dead were interred beneath occupied houses. This tradition is well attested in Area K at the site. Area H, near the palatial complex, revealed a monumental masonry‐constructed chamber tomb. This article presents the results of residue analysis conducted on ceramic vessels placed in these tombs as burial offerings. Hundreds of intramural Middle Bronze tombs with ceramic offerings were excavated in the Levant, but this is the first time the content of the vessels is revealed.
Expanding the phenotype of PIGP deficiency to multiple congenital anomalies‐hypotonia‐seizures syndrome
Authors: Martín‐Grau Carla , Orellana Alonso Carmen , Roselló Piera Mónica , Pedrola Vidal Laia , Llorens‐Salvador Roberto , Quiroga Ramiro , Marín Reina Purificación , Rubio Moll Juan Salvador , Gómez Portero Rosa , Martínez‐Castellano Francisco 
Published: May 2023

AbstractGlycosylphosphatidylinositol‐anchored proteins are involved in multiple physiological processes and the initial stage of their biosynthesis is mediated by PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY, and DMP2 genes, which have been linked to a wide spectrum of phenotypes depending on the gene damaged. To date, the PIGP gene has only been related to Developmental and Epileptic Encephalopathy 55 (MIM#617599) in just seven patients. A detailed medical history was performed in two affected siblings with a multiple malformation syndrome. Genetic testing was performed using whole‐exome sequencing. One patient presented dysmorphic features, congenital anomalies, hypotonia and epileptic encephalopathy as described in PIGA, PIGQ and PIGY deficiencies. The other one was a fetus with a severe malformation disorder at 17 weeks of gestation whose pregnancy was interrupted. Both were compound heterozygous of pathogenic variants in PIGP gene: NM_153682.3:c.2 T > C(p.?) and a 136 Kb deletion (GRCh37/hg19 21q22.13(chr21:38329939‐38 466 066)×1) affecting the entire PIGP gene. Our results extend the clinical phenotype associated to PIGP gene and propose to include it as a novel cause of Multiple Congenital Anomalies‐Hypotonia‐Seizures syndrome.
Evolution of clinical and radiological presentations of spondyloepimetaphyseal dysplasia, RPL13‐related: Description of 11 further cases
Authors: Díaz‐González Francisca , Parrón‐Pajares Manuel , Lucas‐Castro Elsa , Modamio‐Høybjør Silvia , Sentchordi‐Montané Lucia , Seidel Verónica , Prieto Pablo , Tarraso‐Urios Guillermo , Codina‐Sola Marta , Cueto‐González Anna M. , Ballesta‐Martínez Mary J. , Santos‐Simarro Fernando , Sousa Sergio B. , Heath Karen E. 
Published: May 2023

AbstractSpondyloepimetaphyseal dysplasia (SEMD), RPL13‐related is caused by heterozygous variants in RPL13, which encodes the ribosomal protein eL13, a component of the 60S human ribosomal subunit. Here, we describe the clinical and radiological evolution of 11 individuals, 7 children and 4 adults, from 6 families. Some of the skeletal features improved during the course of this condition, whilst others worsened. We describe for the first time “corner fractures” as a feature of this dysplasia which as with other dysplasias disappear with age. In addition, we review the heights and skeletal anomalies of these reported here and previously in a total of 25 individuals from 15 families. In this study, six different RPL13 variants were identified, five of which were novel. All were located in the apparently hotspot region, located in intron 5 and exon 6. Splicing assays were performed for two of the three previously undescribed splicing variants. Until now, all splice variants have occurred in the intron 5 splice donor site, incorporating an additional 18 amino acids to the mutant protein. Here, we report the first variant in intron 5 splice acceptor site which generates two aberrant transcripts, deleting the first three and four amino acids encoded by exon 6. Thus, this study doubles the number of SEMD‐RPL13‐related cases and variants reported to date and describes unreported age‐related clinical and radiological features.
Picture books for young children of incarcerated parents: Through the lens of bibliotherapy
Authors: Spates Kamesha , Monobe Gumiko , James Tierra 
Published: May 2023

AbstractResearch suggests that bibliotherapy can help children cope with life's challenges through age‐appropriate reading and storytelling. Bibliotherapy has been employed to assist children in dealing with grief, divorce, adoption and other stressors. However, limited studies have investigated how this approach can support young children with incarcerated parents. Utilizing bibliotherapy as a framework, this study conducts a thematic analysis of children's picture books published between 1977 and 2014, featuring children of incarcerated parents as main characters to better understand the challenges they face. The study aims to explore the challenges depicted among child characters in picture books addressing parental incarceration for a young reading audience over almost 50 years. Our findings reveal that child characters grapple with various emotional, psychological and social challenges related to the sudden separation from their loved ones. We discuss the implications of each finding in greater detail.
Influence of bisphosphonate treatment on bone substitute performance in osteoporotic conditions
Authors: Camargo Winston Adam , Hoekstra Jan Willem , Jansen John A. , van den Beucken Jeroen J. J. P. 
Published: May 2023

AbstractObjectiveConsidering the elevated number of osteoporotic patients in need of bone graft procedures, we here evaluated the effect of alendronate (ALN) treatment on the regeneration of bone defects in osteoporotic rats. Bone formation was histologically and histomorphometrically assessed in rat femoral condyle bone defects filled with bone graft (Bio‐Oss®) or left empty.MethodsMale Wistar rats were induced osteoporotic through orchidectomy (ORX) and SHAM‐operated. The animals were divided into three groups: osteoporotic (ORX), osteoporotic treated with ALN (ORX + ALN) and healthy (SHAM). Six weeks after ORX or SHAM surgeries, bone defects were created bilaterally in femoral condyles; one defect was filled with Bio‐Oss® and the other one left empty. Bone regeneration within the defects was analyzed by histology and histomorphometry after 4 and 12 weeks.ResultsHistological samples showed new bone surrounding Bio‐Oss® particles from week 4 onward in all three groups. At week 12, the data further showed that ALN treatment of osteoporotic animals enhanced bone formation to a 10‐fold increase compared to non‐treated osteoporotic control. Bio‐Oss® filling of the defects promoted bone formation at both implantation periods compared to empty controls.ConclusionOur histological and histomorphometric results demonstrate that the enteral administration of alendronate under osteoporotic bone conditions leverages bone defect regeneration to a level comparable to that in healthy bone. Additionally, Bio‐Oss® is an effective bone substitute, increasing bone formation, and acting as an osteoconductive scaffold guiding bone growth in both healthy and osteoporotic bone conditions.SignificanceBased on the results of this study, enteral use of ALN mitigates adverse effects of an osteoporotic condition on bone defect regeneration.
Inhibiting leukocyte‐endothelial cell interactions by Chinese medicine Tongxinluo capsule alleviates no‐reflow after arterial recanalization in ischemic stroke
Authors: Liu Shen , Zhang Zhaoxu , He Yannan , Kong Lingbo , Jin Qiushuo , Qi Xiangjia , Qi Dahe , Gao Ying 
Published: May 2023

AbstractAimsDespite successful vascular recanalization in stroke, one‐fourth of patients have an unfavorable outcome due to no‐reflow. The pathogenesis of no‐reflow is fully unclear, and therapeutic strategies are lacking. Upon traditional Chinese medicine, Tongxinluo capsule (TXL) is a potential therapeutic agent for no‐reflow. Thus, this study is aimed to investigate the pathogenesis of no‐reflow in stroke, and whether TXL could alleviate no‐reflow as well as its potential mechanisms of action.MethodsMice were orally administered with TXL (3.0 g/kg/d) after transient middle cerebral artery occlusion. We examined the following parameters: neurological function, no‐reflow, leukocyte‐endothelial cell interactions, HE staining, leukocyte subtypes, adhesion molecules, and chemokines.ResultsOur results showed stroke caused neurological deficits, neuron death, and no‐reflow. Adherent and aggregated leukocytes obstructed microvessels as well as leukocyte infiltration in ischemic brain. Leukocyte subtypes changed after stroke mainly including neutrophils, lymphocytes, regulatory T cells, suppressor T cells, helper T type 1 (Th1) cells, Th2 cells, B cells, macrophages, natural killer cells, and dendritic cells. Stroke resulted in upregulated expression of adhesion molecules (P‐selectin, E‐selectin, and ICAM‐1) and chemokines (CC‐chemokine ligand (CCL)‐2, CCL‐3, CCL‐4, CCL‐5, and chemokine C‐X‐C ligand 1 (CXCL‐1)). Notably, TXL improved neurological deficits, protected neurons, alleviated no‐reflow and leukocyte‐endothelial cell interactions, regulated multiple leukocyte subtypes, and inhibited the expression of various inflammatory mediators.ConclusionLeukocyte‐endothelial cell interactions mediated by multiple inflammatory factors are an important cause of no‐reflow in stroke. Accordingly, TXL could alleviate no‐reflow via suppressing the interactions through modulating various leukocyte subtypes and inhibiting the expression of multiple inflammatory mediators.
Bilateral inferior venae cava combined with the persistent left superior vena cava and hemiazygos continuation of left inferior vena cava with drainage into right atrium: A case report
Authors: Jia Yongmei , Gao Junxia 
Published: May 2023

AbstractThe persistent left superior vena cava (PLSVC) is a common venous abnormality. However, malformation of the bilateral inferior venae cava (IVC) is extremely rare, with an incidence rate of .3%. IVC malformation is associated most frequently with heart defects and isomerism and often has a poor prognosis. We presented a case of vascular malformations in the fetus of bilateral caval veins with the interruption of the left‐sided venous return with hemiazygos continuation in presence of a right‐sided inferior caval vein. Also noted were the PLSVC and a dilated right heart with a widened pulmonary trunk. In this case, there were no heart defects or chromosomal abnormalities, and the newborn postpartum was in a good condition.
The United Kingdom's disappearing wartime imports 1939–45: A statistical, ideological, and historiographical accounting
Authors: Edgerton David 
Published: May 2023

AbstractIn this paper I show inter alia that, by one barely known but official measure, imports of goods into the United Kingdom towards the end of the Second World War were more than twice the best‐known measure. The lower measure is that found in the historical British national accounts and in the Bank of England's A millennium of macroeconomic data. That invaluable compendium in fact has both these measures, and indeed another one also, but this is not clear, and there is no proper explanation of the differences between these series. The differences matter. What I will show to be the most obvious, though not the only legitimate, measure of wartime goods imports suggests that real imports were higher at the end of the war than in the 1930s, and higher as a proportion of gross domestic product (GDP). By contrast the national accounts figures show an absolute real‐terms fall, and a larger still fall as a proportion of GDP. This really mattered in an economy already exceptional for its high imports. In this paper I clarify the nature of the different measures of imports and how they have resulted in a radically different understanding of the British war effort.
Sensitivity to syllable stress regularities in externally but not self‐triggered speech in Dutch
Authors: Emmendorfer Alexandra K. , Bonte Milene , Jansma Bernadette M. , Kotz Sonja A. 
Published: May 2023

AbstractSeveral theories of predictive processing propose reduced sensory and neural responses to anticipated events. Support comes from magnetoencephalography/electroencephalography (M/EEG) studies, showing reduced auditory N1 and P2 responses to self‐generated compared to externally generated events, or when the timing and form of stimuli are more predictable. The current study examined the sensitivity of N1 and P2 responses to statistical speech regularities. We employed a motor‐to‐auditory paradigm comparing event‐related potential (ERP) responses to externally and self‐triggered pseudowords. Participants were presented with a cue indicating which button to press (motor–auditory condition) or which pseudoword would be presented (auditory‐only condition). Stimuli consisted of the participant's own voice uttering pseudowords that varied in phonotactic probability and syllable stress. We expected to see N1 and P2 suppression for self‐triggered stimuli, with greater suppression effects for more predictable features such as high phonotactic probability and first‐syllable stress in pseudowords. In a temporal principal component analysis (PCA), we observed an interaction between syllable stress and condition for the N1, where second‐syllable stress items elicited a larger N1 than first‐syllable stress items, but only for externally generated stimuli. We further observed an effect of syllable stress on the P2, where first‐syllable stress items elicited a larger P2. Strikingly, we did not observe motor‐induced suppression for self‐triggered stimuli for either the N1 or P2 component, likely due to the temporal predictability of the stimulus onset in both conditions. Taking into account previous findings, the current results suggest that sensitivity to syllable stress regularities depends on task demands.