bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics, risk factors, and thyroid profile of patients admitted with acute left ventricular heart failure from a tertiary hospital in Northeast India
Authors: BORO ANUP KUMAR , GUPTA PRABIR KUMAR , PAUL BIPLAB , RAHMAN HABIBAR , GANG SNEHA , BARMAN ANANYA 
Published: April 2023

Introduction:
Heart failure (HF) is a progressive chronic clinical syndrome. Thyroid dysfunction in HF patients has been reported in the literature. We aimed to explore the prevalence of thyroid dysfunction among acute left ventricular failure (LVF) patients admitted to our hospital.

Materials and Methods:
A retrospective study involving 78 patients diagnosed with acute LVF was conducted. Baseline information that included demographics, risk factors, clinical presentations, and biochemical data was recorded. A comparison of acute LVF patients with thyroid dysfunction to those with normal thyroid function was analyzed and documented.

Results:
About 29.5% (n = 23; 63.8 ± 11.4 years) of patients had normal thyroid function and 70.5% (n = 55; 65.3 ± 6 years) had thyroid dysfunction (P = 0.0003). The mean age of the cohort was 64.7 ± 12.4 years and 68% (n = 53) were men. Hypertension was the most common risk factor among both groups (56.5%, n = 13 vs. 67.3%, n = 37; P = 0.0006). Around 13% (n = 3) of patients with normal thyroid function and 20% (n = 11) of patients with thyroid dysfunction expired (P = 0.0325). The most common symptom seen in both groups was shortness of breath (28%, n = 16 vs. 72%, n = 41; P = 0009). There was a high prevalence of HF with reduced ejection fraction (60.8%, n = 14 vs. 65.5%, n = 36; P = 0.0018). Electrocardiography abnormalities were noted in 70.5% (n = 55) of patients of the cohort (65.2%, n = 15 vs. 72.7%, n = 40; P = 0.007). Irregularities in two-dimensional echocardiography and Doppler were seen in 76.5% (n = 59) of patients (69.6%, n = 16 vs. 78.2%, n = 43; P = 0.0004).

Conclusions:
Thyroid dysfunction can cause significant adverse effects on the heart. Early diagnosis and treatment of thyroid abnormalities can reduce and/or prevent the development of serious cardiac problems including HF.
The Effect of Evaporative Cooling Vests on the Physiological and Perceptual Strain Indices of Construction Workers
Authors: Dehghan Habibollah , Mirzabe Mohammad Reza 
Published: April 2023

Aim:
One of the most harmful agents in construction sites is heat exposure. The aim of this study was to evaluate the performance of new evaporative cooling vests in construction workers.

Materials and Methods:
This case–control study was implemented on 60 construction workers in hot conditions (air temperature 49.0°, relative humidity 5.5%) in the summer of 2019. In this study, 30 people with cooling vests (case group) and 30 people without cooling vests (control group) were working for 120 min in a hot environment. In both groups, heart rate oral temperature and wet bulb globe temperature (WBGT) index were measured. Moreover, the Perceptual Strain Index (PeSI) and Heat Strain Score Index (HSSI) questionnaires were completed by the workers. Data were analyzed after inter to SPSS16 software.

Results:
All of the WBGT values were higher than occupational exposure limit. The mean and standard deviation (SD) of the work heart rate in the case and control groups, was equal to 111.1 ± 7.6 beats per minute (bpm) and 114.3 ± 7.9 bpm respectively (P < 0.05). Also the average and SD of the oral temperature in the case and control groups, respectively, was equal to 36.36 ± 0.41 and 36.37 ± 0.55. There was no statistically significant difference. Mean and SD of Physiological Strain Index (PSI), in case and control groups, were 2.53 ± 0.66 and 3.64 ± 0.81, respectively. The mean and SD of the PeSI and the HSSI in the case group were 4.64 ± 0.79 and 10.12 ± 1.71, respectively, and in the control group, 6.41 ± 0.85 and 15.88 ± 0.1.43. Statistically, the difference between PSI, PeSI, and HSSI means was significant.

Conclusions:
This study results showed that hot environmental conditions were stressful for construction workers and also Iranian evaporative cooling vests (Hifitcool brand) were able to reduce perceptual and physiological heat strain in construction workers in the hot conditions.
Fusion Protein Consisting of Hemagglutinin Small Subunit and Truncated Nucleoprotein as a Universal Influenza Vaccine Candidate: Starting In-Silico Evaluation Toward In Vitro Expression
Authors: Morshedi Fatemeh , Nazeri Elaheh , Saleh Maryam , Farahmand Behrokh 
Published: April 2023

Background:
Influenza virus is a respiratory pathogen, which causes high degree of mortality and morbidity during seasonal epidemics and sporadic pandemics. By selecting conserved antigenic proteins, for example, hemagglutinin small subunit (HA2) and nucleoprotein (NP), we aimed to develop a vaccine based on a fusion protein leading to both cellular and humoral responses that are the most challenging aspects in designing a universal vaccine.

Materials and Methods:
The bioinformatics analysis was performed for HA2-NP structure and function prediction. Primers for the antigenic part of NP were designed using bioinformatics tools. The desired product was amplified via polymerase chain reaction using the designed primers, which was then penetrated into T vector, followed by insertion into pET28a vector in order to construct pET28a/NP. The pET28a/HA2, previously generated in our lab, was digested with the same restriction enzymes as pET28a/NP (HindIII/Xhol). Then, NP was inserted to the downstream region of HA2 to construct pET28a/HA2.

Results:
The generated pET28a/HA2-NP was transformed into Escherichia coli BL21 (DE3). The expression was induced by isopropyl β-d-l-thiogalactopyranoside. The results showed that the antigenic segment of NP was successfully cloned into pET28a/ HA2. The protein band of HA2-NP was observed on sodium dodecyl sulfate polyacrylamide gel electrophoresis, confirmed by Western blotting and purified with Ni-NTA purification system (QIAGEN, Germany).

Conclusion:
As currently available vaccines can cause some allergic reactions, using a chimer protein based on the bioinformatics analysis is continual, safe, and affordable, thus stimulating both cellular and humoral immunity systems. Our construct could potentially provide a basis for a universal vaccine candidate.
Optimized Solvents for the Maceration of Phenolic Antioxidants from Curcuma xanthorrhiza Rhizome using a Simplex Centroid Design
Authors: Nurcholis Waras , Marliani Nelly , Asyhar Rayandra , Minarni Minarni 
Published: April 2023

Background:

Curcuma xanthorrhiza Roxb., from the Zingiberaceae family, is a famous plant native to Indonesia that is highly effective in treating diseases due to the various chemical compounds it contains.

Objective:
This study aims to optimize the extraction process for the phenolic content, with its antioxidant activity, from the rhizome of C. xanthorrhiza using different solvent (water, acetone, methanol, and ethanol) systems based on the simplex centroid design using the Design Expert 13.0 program.

Methods and Material:
Total phenolic content (TPC) was analyzed by colorimetry using Follin–Ciocalteu, while the antioxidant activity was measured based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) using a spectrophotometer.

Results:
To measure TPC and DPPH, a special cubic model was used; to measure FRAP, a linear model was utilized. Each model demonstrated a good match with the R2 values for TPC (0.9808), DPPH (0.9583), and FRAP (0.7872). The combination of a mixture of water (0.409), acetone (0.307), and methanol (0.284) with a desirability level of 0.723, resulted in a TPC of 34.112 mg gallic acid equivalent (GAE)/g dry weight (DW), DPPH of 26.533 μmol Trolox equivalent (TE)/g DW, and FRAP of 92.353 μmol TE/g DW. This showed a high extraction efficiency which was optimal.

Conclusions:
The best condition to extract the rhizomes of C. xanthorrhiza was a ternary combination of solvents including water, acetone, and methanol in the proportions of 0.409, 0.307, and 0.284, respectively, with a desirability level of 0.723.
Bixin and Fuxoxanthin Alone and in Combination with Cisplatin Regulate ABCC1 and ABCC2 Transcription in A549 Lung Cancer Cells
Authors: Chandra Ferdy , Tania Teresa F. , Nurcahyanti Agustina D. R. 
Published: April 2023

Background:
The ATP-Binding Cassette (ABC) transporter has long been studied to confer drug resistance in human tumors and play important role in metabolic processes and cellular signaling. The overexpression of ABCB1, ABCC1, ABCC2, ABCC3, and ABCG2 leads to decreased sensitivity of lung cancer to cisplatin. At the transcription level, the expression of ABC transporters is highly regulated and requires the complex interplay of factors involved in differentiation and development, cell survival and apoptosis upon intrinsic and environmental stress. The p53 regulation of drug-resistance genes is also complex yet not well understood. Previously, we demonstrated the synergistic interaction between bixin or fucoxanthin with cisplatin in A549 lung cancer cells.

Objectives:
Current study aims to identify whether carotenoids enhancing therapeutic effect of Cisplatin due to the ability to reverse drug resistance associated proteins, such as ABC transporter and regulating the tumor suppressor corresponding gene, p53.

Methods:
Real-Time Quantitative-Polymerase Chain Reaction (RT-qPCR) was performed to estimate the expression level of ABCC1 and ABCC2, and p53 of A549 cell lines in response to carotenoids alone and in combination with cisplatin.

Results and Conclusion:
The administration of bixin or fucoxanthin decreases the expression of ABCC1 and ABCC2. Both carotenoids, either alone or in combination with cisplatin, upregulated p53 gene expression indicating the mechanism of proliferation inhibition and apoptosis occurs via the p53 caspase-independent pathway.
Rancang Bangun Sistem Informasi Pencarian dan Penyewaan Rumah Kost di Palangka Raya Berbasis Website
Authors: Novianti Angellita , Nugrahaningsih Nahumi 
Published: April 2023

Information systems are currently growing rapidly which allows all jobs in life to be assisted by information technology. This technology that can help make things easier, faster, safer, and more effective is clearly very useful for anyone who uses it. This includes helping micro, small and medium enterprises (MSME),especially boarding house owners, in promoting their boarding houses and making it easier for someone who is looking for a boarding house to live in. This boarding house search and rental information system is a website-based information system as a means to provide boarding house information for boarding house seekers, as well as for boarding house managers to promote the boarding houses they rent and manage all things related to the boarding house on the website quickly and easy. The methodology used in making this Information System is to use the waterfall method with stages, with stages, namely Requitments Definition depicted by Flowcharts, Requirements Analysis and Definition described by DFD (Data Flow Diagrams), ERD (Entity Relationship Diagrams) and databases. Implementation and Unit Testing with the programming languages used, namely HTML, PHP, CSS, Bootstrap, Javascript and MySQL, Integration and System Testing using the Blackbox Method.
Sistem Informasi Penyewaan Lapangan Futsal Indoor Se-Kota Palangka Raya Berbasis Website
Authors: Vianus Rezaski Yoan , Nugrahaningsih Nahumi 
Published: April 2023

The use of computers and mobile phones in the field of ordering and in the Internet world is growing, because humans are always looking for new breakthroughs in the development of a remote information system that provides access rights and detailed information for the community. Therefore, it is necessary to have a futsal field booking website. so by making this website it can be a means for futsal field entrepreneurs in the field of field rental in Palangkaraya to develop their business. Therefore, a web-based futsal field ordering information system is needed to provide convenience to the public. Apart from being a medium to promote the field, this information system makes it easy for the public to order the desired futsal field. This Futsal Universe application with this system is expected that customers can see the latest information on field rentals on the Futsal Universe Website if there is an empty or full field, they can see it without having to go to the field directly and can place an order anytime and anywhere without having to go to the field
Pengaruh Kepemimpinan Transformasional Kepala Sekolah dan Iklim Organisasi Sekolah terhadap Produktivitas Sekolah: Studi Kasus di SMPI Nuurushshibyan (YAPIN) Cileungsi
Authors: Norman Efrita , Dzulfikar Dzulfikar , Sarta Sarta 
Published: April 2023

The problem of education in Indonesia still requires extra attention, both in terms of government policies and internal problems at the school level. The school as an organization is led by a principal who is authorized to apply a certain leadership style for the realization of the school's goals. To achieve the goals of national education and realize the vision of the school, factors are needed that can be successful ranging from leadership, educators, staff, infrastructure, work climate and several factors in it. So that the objectives of this study are: (1) To analyze how much influence the principal's transformational leadership has on school productivity at SMPI Nuurushshibyan Cileungsi; (2) To analyze how much influence the school organizational climate has on school productivity at SMPI Nuurushshibyan Cileungsi; (3) To analyze how much influence the principal's transformational leadership and climate school organization of school productivity at SMPI Nuurshshibyan Cileungsi. This research uses a quantitative approach, using a descriptive study method, which is a method directed at solving problems by explaining or describing what the results of the study are, all populations are made into samples so that they are called saturated samples. The results of this study are; (1) The influence of transformational principal leadership on productivity was highly influential by 36.4%; (b) The organizational climate has a 34.5% influence on school productivity; and (c) For transformational principal leadership and the school's organizational climate both have a 72% effect on school productivity.
Keywords: Transformational Principal leadership, organizational climate and school productivity.
Konsep Modernisasi dan Reformasi Pemikiran Islam Dalam Bidang Kalam
Authors: Pratomo Sigit Adi 
Published: April 2023

This paper discusses the concept of modernization and reform of Islamic thought in the field of kalam. The development of the history of Islamic culture and thought consists of three periods: the classical period which lasted from 650-1250 AD, the medieval period which lasted from 1250-1800 AD, the modern period which lasted from 1800 AD until now. Then came many figures who called for ideas as well as reform movements that contained the vision of Islamic civilization. In the field of kalam, their thoughts have varied patterns, according to the circumstances and conditions of the people. In an advanced society, the thinking of kalam tends to be rational, which requires that everything is logical and empirical. In developing societies, most likely on the midline. Meanwhile, in disadvantaged communities, the thinking of kalam will tend to lead to the concept of jabariyah which surrenders to everything that is in front of it. Several prominent Islamic thinkers in the field of kalam in modern times include Muhammad Abduh, Sayyid Ahmad Khan Ismail Raji Al-Faruqi, Hasan Hanafi and so on. Each of them shows a different pattern in understanding religious texts which then gives birth to their own understanding of kalam. From this, a question arises from the author, how is the concept of modernization and reform of Islamic thinkers as mentioned above in the field of kalam. The conclusion in this paper uses a historical approach, with the aim of trying to reveal the values of truth in society so that it should be actualized in the future.
Keywords: Modernization, Reform, Islamic Thought, Kalam
LETRAMENTO MATEMÁTICO: COMPREENSÕES EMERGENTES PARA A APRENDIZAGEM EM MATEMÁTICA NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL
Authors: Santos Anderson Oramisio , Oliveira Guilherme Saramago de , Oliveira Camila Rezende 
Published: April 2023

Objetiva-se com essa pesquisa favorecer a elaboração de conjecturas, e reflexões emergentes sobre o Letramento Matemático e as práticas pedagógicas nos anos iniciais do Ensino Fundamental. A compreensão especifica sobre Letramento Matemático implica em uma prática de ensino e aprendizagem voltada para o contexto social, cultural dos estudantes e a valorização dos conhecimentos prévios. A pesquisa é de cunho qualitativa, bibliográfica- documental apoiada em teóricos que discutem o tema, abarcada dos documentos oficiais do (BNCC, PCN, OCDE /PISA). Os resultados apontam a necessidade de aprofundamentos de estudos na perspectiva do Letramento Matemático que favoreçam a relação entre o Letramento Matemático, os conhecimentos matemáticos e a práticas sociais, visto que com a aprovação da BNCC, que orienta a elaboração dos currículos escolares no território brasileiro, o Letramento Matemático passa a ser concebido como um direito de aprendizagem.
FORMAÇÃO DOCENTE FRENTE AOS IMPERATIVOS DE FORMAÇÃO POR COMPETÊNCIAS DA BNCC
Authors: Techio Julia Patricia , Neitzel Odair 
Published: April 2023

O presente artigo deriva do trabalho de investigação de mestrado, sendo uma revisão bibliográfica e documental em perspectiva hermenêutica e analítica, com o objetivo de discutir e refletir sobre o conceito de competência presente na Base Nacional Curricular Comum (BNCC). A investigação dialoga com um conjunto de documentos e referências, com ênfase nos escritos de Philippe Perrenoud. Resgata a trajetória de construção e aprovação da BNCC, documento que norteia e orienta o currículo escolar da educação básica brasileira e reconstrói alguns elementos políticos dos bastidores da construção da política. Estes acabaram inclinando a BNCC para uma perspectiva neoliberal e mercadológica, enfatizando a formação técnica e, consequentemente, enfraquecendo o lugar da docência. Assim, estabelece algumas reflexões a respeito das implicações do termo “competência”, “pedagogia das competências” para a escola e a formação de professores. O caráter técnico-profissional da BNCC, de certo modo enfraquece a formação crítica e humana. Consequentemente descontrói o papel social e formativo da escola, que passa a ocupar o lugar de subordinação às exigências do mercado, sendo o professor um mero executor de tarefas.
American Female Missionary Victims of Epidemics
Authors: KUŞ Ayşegül , ALAN Gülbadi 
Published: April 2023

Epidemics have always played an important role in human history and have deeply affected the individual, social and economic lives of states, communities and people. The communities located at the crossing point of civilizations and being on trade transition routes have been more affected by epidemics due to the intensity of interaction. This is probably why Anatolia has always faced epidemics from past to present. One of the time periods when these epidemics are intense is the process from 1820 to the end of the World War I. It is known that the American Board missionary organization was operating in the Ottoman lands during these epidemic times. For this reason, it is seen that the effects of the epidemic were voiced by missionaries, and even became the subject of American Board reports.
This study is about the female missionaries (married or single) who worked on behalf of the American Board organization, who left their country for an ideal, came to the Ottoman lands and lost their lives due to some epidemics. First of all, the subject of the study will be revealed through the information in the documents of the American Board, the articles in the Board’s publication called "The Missionary Herald". In the light of the aforementioned documents, the aim of the study is to both reveal the identities of the women missionaries who lost their lives in the Ottoman lands due to some epidemic diseases and also to relate which disease they died from, and thus to make some contributions to the literature.
Intergranular Corrosion of Feedstock Modified—Additively Manufactured Stainless Steel After Sensitization
Authors: Vukkum Venkata Bhuvaneswari , Delvecchio Evan , Christudasjustus Jijo , Storck Steven , Gupta Rajeev Kumar 
Published: April 2023

Laser powder bed fusion (LPBF), a metal additive manufacturing technique, was conducted on feedstock-modified 316L stainless steel (316L) powder produced by ball-milling of commercial 316L and 1 wt% additive (cerium oxide—CeO2, lanthanum (III) nitrate hexahydrate—La(NO3)3·6H2O, and chromium nitride—CrN). The feedstock-modified LPBF-316L specimens were sensitized at 675°C for 24 h, and the influence of additives on intergranular corrosion (IGC) was investigated following ASTM G108-94 and A262-14 standards. The LPBF-316L with La(NO3)3·6H2O showed higher IGC resistance. The microstructure of the LPBF specimen was investigated and correlated to understand the improved IGC resistance of LPBF-316L with La(NO3)3·6H2O additive.
Impact of chronic obstructive pulmonary disease on heart failure hospitalizations after an acute myocardial infarction
Authors: Yandrapalli Srikanth , Pandit Maya , Malik Aaqib , Gupta Kanika , Nabors Christopher , Jain Diwakar , Frishman William , Aronow Wilbert 
Published: April 2023

IntroductionThe presence of chronic obstructive pulmonary disease (COPD) can impact the management of acute myocardial infarction (AMI) and is associated with higher mortality. Few studies addressed COPD impact on heart failure hospitalisations (HFHs) in AMI survivors.Material and methodsAdult survivors of an AMI between January and June 2014 were identified from the US Nationwide Readmissions Database. The impact of COPD on HFH within 6 months, fatal HFH and the composite of in-hospital HF or 6-month HFH was studied.ResultsOf 237,549 AMI survivors, patients with COPD (17.5%) were older, more likely female, had a higher prevalence of cardiac comorbidities and a lower coronary revascularization rate. In-hospital HF was more frequent in patients with COPD (47.0% vs. 25.4%; p < 0.001). HFH within 6 months occured in 12,934 (5.4%) patients, at a 114% higher rate in patients with COPD (9.4% vs. 4.6%, OR = 2.14, 95% CI : 2.01–2.29; p < 0.001), which was attenuated to a 39% higher adjusted risk (OR = 1.39, 95% CI: 1.30–1.49). Findings were consistent across subgroups of age, AMI type, and major HF risk factors. Mortality during a HFH (5.7% vs. 4.2%, p < 0.001) and the rate of the composite HF outcome (49.0% vs. 26.9%, p < 0.001) were significantly higher in patients with COPD.ConclusionsCOPD was present in 1 of 6 AMI survivors and was associated with worse HF related outcomes. The increased HFH rate in COPD patients was consistent across several clinically relevant subgroups and these findings highlight the need for optimal in-hospital and post-discharge management of these higher-risk patients.