bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curative Management After Endoscopic Resection for Esophageal Squamous Cell Carcinoma Invading Muscularis Mucosa or Shallow Submucosal Layer–Multicenter Real-World Survey in Japan
Authors: Katada Chikatoshi , Yokoyama Tetsuji , Hirasawa Dai , Iizuka Toshiro , Kikuchi Daisuke , Yano Tomonori , Hombu Takuya , Yoshio Toshiyuki , Yoshimizu Shoichi , Ono Hiroyuki , Yabuuchi Yohei , Terai Shuji , Hashimoto Satoru , Takahashi Kazuya , Tanaka Shinji , Urabe Yuji , Arima Miwako , Tanabe Satoshi , Wada Takuya , Furue Yasuaki , Oyama Tsuneo , Takahashi Akiko , Sakamoto Yasutoshi , Muto Manabu 
Published: January 2023

INTRODUCTION:
Curative management after endoscopic resection (ER) for esophageal squamous cell carcinoma (ESCC), which invades the muscularis mucosa (pMM-ESCC) or shallow submucosal layer (pSM1-ESCC), has been controversial.

METHODS:
We identified patients with pMM-ESCC and pSM1-ESCC treated by ER. Outcomes were the predictive factors for regional lymph node and distant recurrence, and survival data were based on the depth of invasion, lymphovascular invasion (LVI), and additional treatment immediately after ER.

RESULTS:
A total of 992 patients with pMM-ESCC (n = 749) and pSM1-ESCC (n = 243) were registered. According to the multivariate Cox proportional hazards analysis, pSM1-ESCC (hazard ratio = 1.88, 95% confidence interval 1.15–3.07, P = 0.012) and LVI (hazard ratio = 6.92, 95% confidence interval 4.09–11.7, P < 0.0001) were associated with a risk of regional lymph node and distant recurrence. In the median follow-up period of 58.6 months (range 1–233), among patients with risk factors (pMM-ESCC with LVI or pSM1-ESCC), the 5-year overall survival rates, relapse-free survival rates, and cause-specific survival rates of patients with additional treatment were significantly better than those of patients without additional treatment; 85.4% vs 61.5% (P < 0.0001), 80.5% vs 53.3% (P < 0.0001), and 98.5% vs 93.1% (P = 0.004), respectively. There was no difference in survival rate between the chemoradiotherapy and surgery groups.

DISCUSSION:
pSM1 and LVI were risk factors for metastasis after ER for ESCC. To improve the survival, additional treatment immediately after ER, such as chemoradiotherapy or surgery, is effective in patients with these risk factors.
„Das ging ja nur hier…“ – Wohneigentümerstrukturen und Segregation in ostdeutschen Großwohnsiedlungen
Authors: Bernt Matthias , Böhmer Felix 
Published: January 2023

Throughout the last two decades, large housing estates in eastern Germany have become the scene of an increased concentration of low-income households. At the same time, considerable shifts in the structure of home ownership have been documented in these areas. National and international investors have acquired large housing stocks here and become a fundamental part of the local housing markets. This paper discusses the connection between both developments. Based on a case study in two large housing estates in Halle (Saale) and Schwerin, it is argued that the relative impoverishment of large housing estates can be traced back to two developments on the supply side: On the one hand, municipal housing companies are increasingly made responsible for the provision of homes for households that cannot provide for themselves on the market. Due to the uneven spatial distribution of municipal housing, this leads to an increased concentration of poor households in the large housing estates. On the other hand, letting policies of financial investors are characterised by tight yield requirements. In view of a rather restrained demand for the housing they manage, they therefore increasingly rent their flats to population groups that are avoided by other landlords. Together, these developments operate like a ‘segregation machine’, which continuously shifts low-income population groups to the large housing estates.
Total mean curvatures of Riemannian hypersurfaces
Authors: Ghomi Mohammad , Spruck Joel 
Published: January 2023

Abstract
We obtain a comparison formula for integrals of mean curvatures of Riemannian hypersurfaces via Reilly’s identities. As applications, we derive several geometric inequalities for a convex hypersurface

Γ

\Gamma

in a Cartan-Hadamard manifold

M

M

. In particular, we show that the first mean curvature integral of a convex hypersurface

γ

\gamma

nested inside

Γ

\Gamma

cannot exceed that of

Γ

\Gamma

, which leads to a sharp lower bound for the total first mean curvature of

Γ

\Gamma

in terms of the volume it bounds in

M

M

in dimension 3. This monotonicity property is extended to all mean curvature integrals when

γ

\gamma

is parallel to

Γ

\Gamma

, or

M

M

has constant curvature. We also characterize hyperbolic balls as minimizers of the mean curvature integrals among balls with equal radii in Cartan-Hadamard manifolds.
Deciphering the role of monocyte and monocyte distribution width (MDW) in COVID-19: an updated systematic review and meta-analysis
Authors: Ligi Daniela , Lo Sasso Bruna , Henry Brandon M. , Ciaccio Marcello , Lippi Giuseppe , Plebani Mario , Mannello Ferdinando 
Published: January 2023

Abstract
The SARS-CoV-2 infection is characterized by both systemic and organ hyper-thromboinflammation, with a clinical course ranging from mild up-to critical systemic dysfunction and death. In patients with coronavirus disease 2019 (COVID-19) the monocyte/macrophage population is deeply involved as both trigger and target, assuming the value of useful diagnostic/prognostic marker of innate cellular immunity. Several studies correlated morphological and immunophenotypic alterations of circulating monocytes with clinical outcomes in COVID-19 patients, concluding that monocyte distribution width (MDW) may retain clinical value in stratifying the risk of disease worsening. Through an electronic search in Medline and Scopus we performed an updated literature review and meta-analysis aimed to explore the association between increased MDW levels and illness severity in COVID-19 patients, deciphering role(s) and function(s) of monocytes in the harmful network underlining SARS-CoV-2 infection. We found that significantly elevated MDW values were frequently present in COVID-19 patients who developed unfavorable clinical outcomes, compounded by a significant association between monocyte anisocytosis and SARS-CoV-2 outcomes. These findings suggest that blood MDW index and its scatter plot could represent useful routine laboratory tools for early identification of patients at higher risk of unfavorable COVID-19 and for monitoring the progression of viral infection, clinical outcomes, and therapeutic efficacy throughout hospitalization. According to this evidence, therapeutic decisions in patients with SARS-CoV-2 infection could benefit from monitoring MDW value, with administration of drugs limiting thrombo-inflammation due to monocyte hyper-activation in patients with severe/critical COVID-19 disease.
The multistep Laplace optimized decomposition method for solving fractional-order coronavirus disease model (COVID-19) via the Caputo fractional approach
Authors: Maayah Banan , Moussaoui Asma , Bushnaq Samia , Abu Arqub Omar 
Published: January 2023

Abstract
COVID-19, a novel coronavirus disease, is still causing concern all over the world. Recently, researchers have been concentrating their efforts on understanding the complex dynamics of this widespread illness. Mathematics plays a big role in understanding the mechanism of the spread of this disease by modeling it and trying to find approximate solutions. In this study, we implement a new technique for an approximation of the analytic series solution called the multistep Laplace optimized decomposition method for solving fractional nonlinear systems of ordinary differential equations. The proposed method is a combination of the multistep method, the Laplace transform, and the optimized decomposition method. To show the ability and effectiveness of this method, we chose the COVID-19 model to apply the proposed technique to it. To develop the model, the Caputo-type fractional-order derivative is employed. The suggested algorithm efficacy is assessed using the fourth-order Runge-Kutta method, and when compared to it, the results show that the proposed approach has a high level of accuracy. Several representative graphs are displayed and analyzed in two dimensions to show the growth and decay in the model concerning the fractional parameter α values. The central processing unit computational time cost in finding graphical results is utilized and tabulated. From a numerical viewpoint, the archived simulations and results justify that the proposed iterative algorithm is a straightforward and appropriate tool with computational efficiency for several coronavirus disease differential model solutions.
First-principles investigation of phase stability and elastic properties of Laves phase TaCr2 by ruthenium alloying
Authors: Wei Shishi , Xiao Xuan , Zhou Kai , Yao Jing , Chen Dezhi 
Published: January 2023

Abstract
Based on the first-principles method of density functional theory, the microscopic mechanism of the effect of addition of alloying element Ru content on the stability and elastic properties of Laves phase TaCr2 was investigated by parameters such as formation enthalpy, electronic structure, and elastic constants. The addition of Ru atoms tends to preferentially occupy the lattice sites of Cr. With the increase in the Ru content, the alloying ability of Ta8Cr16−n
Ru
n
(n = 0–6) becomes progressively weaker, the stability gradually decreases, whereas the Poisson’s ratio grows. The bonding peak appears to drop and widen, weakening the bonding strength of Ta–Cr atoms, rendering the shear deformation to be performed easily, thereby improving toughness. When the Ru content rises to 20.83 at%, the bulk modulus, shear modulus, Young’s modulus, and Poisson’s ratio of the alloy attain the maximum value, the brittleness diminishes to the most extent, the resistance to elastic deformation is the strongest, as well at the optimum fracture toughness.
Investigation of space-continuous deformation from point clouds of structured surfaces
Authors: Ötsch Elisabeth , Harmening Corinna , Neuner Hans 
Published: January 2023

Abstract
One approach to estimate space-continuous deformation from point clouds is the parameter-based epochal comparison of approximating surfaces. This procedure allows a statistical assessment of the estimated deformations. Typically, holistic geometric models approximate the scanned surfaces. Regarding this, the question arises on how discontinuities of the object’s surface resulting from e.g. single bricks or concrete blocks, influence the parameters of the approximating continuous surfaces and in further consequence the derived deformation. This issue is tackled in the following paper. B-spline surfaces are used to approximate the scanned point clouds. The approximation implies solving a Gauss–Markov-Model, thus allowing accounting for the measurements’ stochastic properties as well as propagating them on the surfaces’ control points. A parametric comparison of two B-spline surfaces can be made on the basis of these estimated control points. This approach is advantageous with regard to the transition of the space-continuous deformation analysis to a point-based task, thus ensuring the applicability of the well-established congruency model. The influence of the structure’s geometry on the surfaces’ control points is investigated using terrestrial laser scans of a clinker facade. Points measured in the joints are eliminated using an own developed segmentation approach. A comparison of the results obtained from segmented as well as from unsegmented laser scans for the B-spline approximation and the subsequent deformation analysis provides information about the structure-related influence. An aqueduct arc is used as measuring object in this study. For the intended comparison, data sets, which contain possible influences due to changes of the mechanical loads, are analysed.
Ectopic adrenocorticotrophic hormone syndrome secondary to treatment-related neuroendocrine differentiation of metastatic castrate-resistant prostate cancer
Authors: Tan Chelsea , Triay Jessica 
Published: January 2023

Summary
A 64-year-old man with progressive metastatic castrate-resistant prostate adenocarcinoma presented with recurrent fluid overload, severe hypokalaemia with metabolic alkalosis and loss of glycaemic control. Clinical features were facial plethora, skin bruising and proximal myopathy. Plasma adrenocorticotrophic hormone (ACTH), serum cortisol and 24-h urinary cortisol levels were elevated. Low-dose dexamethasone failed to suppress cortisol. Pituitary MRI was normal and 68Gallium-DOTATATE PET–CT scan showed only features of metastatic prostate cancer. He was diagnosed with ectopic ACTH syndrome secondary to treatment-related neuroendocrine prostate cancer differentiation. Medical management was limited by clinical deterioration, accessibility of medications and cancer progression. Ketoconazole and cabergoline were utilised, but cortisol remained uncontrolled. He succumbed 5 months following diagnosis. Treatment-related neuroendocrine differentiation of prostate adenocarcinoma is a rare cause of ectopic ACTH syndrome.

Learning points

Neuroendocrine differentiation following prostate adenocarcinoma treatment with androgen deprivation has been described.

Ectopic adrenocorticotrophic hormone (ACTH) syndrome should be considered where patients with metastatic prostate cancer develop acute electrolyte disturbance or fluid overload.

Ketoconazole interferes with adrenal and gonadal steroidogenesis and can be used in ectopic ACTH syndrome, but the impact may be insufficient. Inhibition of gonadal steroidogenesis is favourable in prostate cancer.

More data are required to evaluate the use of cabergoline in ectopic ACTH syndrome.

Ectopic ACTH syndrome requires prompt management and is challenging in the face of metastatic cancer.
Los invertebrados acuáticos como indicadores ecológicos
Authors: Roldán Gabriel 
Published: January 2023

Muchos descubrimientos han hecho furor en la historia del desarrollo de los conceptos biológicos. Darwin, con su teoría sobre la evolución de las especies, causó un gran revuelo a mediados del siglo pasado. Mendel, al descubrir las leyes de la herencia, dio un vuelco total a las teorías entonces exitentes sobre la tansmisión de caracteres hereditaros. Muchos otros adelantos científicos en el campo de la bioquímica, la fisiología, el comportamiento, la adaptación, etc. han acaparado igualmente la atención del hombre en épocas diferentes.
El hombre nativo de las grandes alturas
Authors: Hurtado Alberto 
Published: January 2023

Es evidente que el estudio del hombre que ha nacido y vivido milenariamente en ambientes de grandes alturas, permite darnos la más adecuada comprensión de cómo el cuerpo humano puede tolerar al máximo la hipoxia costante derivada de una disminución en la presión parcial (tensión) de oxígeno en el aire inspirado.
Principios del síntoma: del desciframiento al goce
Authors: Becerra Fuquen Fabián 
Published: January 2023

El presente texto busca despejar algunos principios para la comprensión del síntoma, realizando un abordaje a los textos de Freud y Lacan con los que se busca elucidar la constitución del sentido en el síntoma, su génesis, su estatuto inconsciente, su relación con la satisfacción pulsional y con ello poder comprender el goce del síntoma.
Poder constatar esto, implica darle una vuelta a los principios que Freud y Lacan advierten en su teoría, para así comprender ¿por qué un síntoma cobra vida?, ¿cómo un síntoma logra decir algo?, y más aún ¿por qué un sujeto goza de su síntoma? Acercarse a una respuesta, permite tomar posición en la clínica del síntoma para pensar su orientación.
El duelo: UN-a batalla.
Authors: Vargas David Andres 
Published: January 2023

El presente ensayo aborda el duelo desde su doble acepción: desde la connotación freudiana de trabajo frente a la pérdida de un objeto de amor; y en tanto batalla. Se señalan diferentes tiempos lógicos del duelo y las implicaciones estructurales que estos conllevan. Igualmente, se advierte el estatuto ético del duelo por el acto que la resolución de todo duelo exige vía el sacrificio que el sujeto realiza de un trozo de sí. Los cambios a nivel del fantasma, la función de los rituales funerarios, así como la relación entre castración y muerte, son otras de las temáticas desarrolladas en este texto. Palabras Clave: duelo, falta, ética, fantasma Le deuil un-e bataille Résumé Dans cet essai le deuil est abordé dès son double acception : à partir de la connotation freudienne de travail face à la perte d'un objet d'amour; et en tant que bataille. Des différents temps logiques du deuil sont signalés ainsi que les implications structurales qu’ils entraînent. De même, l’on remarque le statut éthique du deuil à travers l'acte que la résolution de tout deuil exige au moyen du sacrifice que le sujet fait d’un morceau de lui-même. Les changements qui deviennent au niveau du fantôme, la fonction des rites funéraires, ainsi que la relation entre castration et mort, seront aussi des sujets développés dans ce texte. Mots-clés: deuil, manque, éthique, fantôme The mourning, a struggle Summary The current essay deals with the mourning from its double meaning: from Freudian connotation of work facing up the loss of an object of love; and as a struggle. Several normal times of mourning and the structural implications they involved are highlighted. As well, an ethical status of the mourning is noticed, due to the determination every mourning demands through the sacrifice of a part of the subject itself. The changes concerning the ghost, the function of funeral rites, as well as the relation between castration and death are other topics to be developed in this text.Key words: mourning, lack, ethics, ghost. .
Qué enseña Atalia de Racine al psicoanálisis.
Authors: Maya Restrepo Beatriz Elena 
Published: January 2023

El presente texto intenta descifrar el método que Lacan empleó en su Seminario sobre la Psicosis para leer un aparte de la Atalía de Racine, en la búsqueda de aquello que enseñan los poetas al psicoanálisis, teniendo claro que no se trata de psicoanálisis aplicado sino de aplicación del método analítico definido por él mismo como “ese método que procede al desciframiento de los significantes sin consideraciones por ninguna presupuesta forma de existencia del significado”. What does Racine’s Atalia show psychoanalysis? AbstractThe current text aims to decipher the method used by Lacan in his Seminar about the Psychosis to read a passage of Racine's Atalia, searching for what the poets show psychoanalysis. All this, bearing in mind it is not applied psychoanalysis but the application of the analytic method defined by him as “that method undertaking the interpretation of the signifier without consideration of any supposedly existing form of the signified.” Quel est l’enseignement d’Atalia de Racine à la Psychanalyse RésuméCe texte essaie de décrypter la méthode utilisée par Lacan dans son Séminaire sur la Psychose pour lire un extrait de l’Atalia de Racine, en cherchant ce que les poètesenseignent à la psychanalyse, sachant qu’il ne s’agit pas de psychanalyse appliquée mais d’une application de la méthode analytique définie par lui-même comme «cette méthode qu'entraine le déchiffrement des signifiants sans considérations par aucune forme présupposée de l’existence du signifié.»
De neurastenia a neurosis obsesiva.
Authors: Acosta Mesa Humberto 
Published: January 2023

Este artículo tiene la intención de desentrañar el concepto de neurosis obsesiva a partir de la psiquiatría clásica, y en ese recorrido conducirse hasta los contemporáneos de Freud para establecer finalmente el concepto al interior de la formalización freudiana. Un recorrido fenomenológico que culmina esencialmente en su establecimiento a partir de la neurastenia, nosa problemática y generalizante cuya explicación, también confusa, se atribuía a una degeneración nerviosa y que finalmente Freud va desagregando hasta llegar a la particularización de la neurosis obsesiva con una etiología psíquica basada en el conflicto y la defensa. From neurasthenia to obsessive neurosis AbstractThis article aims to decipher the concept of obsessive neurosis from traditional psychiatry, and during this journey to head towards Freud’s contemporaries in order to establish finally this concept within the Freudian formalization. A phenomenological route ending essentially in its establishment from neurasthenia, problematic and generalizing thing whose explanation, also confused, was attributed to a nervous degeneration and which finally Freud is disintegrating until the particularization of the obsessive neurosis with a psychic etiology based on the conflict and the defense. De la neurasthénie à la névrose obsessionnelle RésuméCet article a l’intension de percer le concept de névrose obsessionnelle à partir de la psychiatrie classique, et sur ce parcours, se diriger jusqu'aux contemporains de Freud pour établir finalement le concept à l‘intérieur de la formalisation Freudienne. Un parcours phénoménologique qui culmine essentiellement avec son établissement à partir de la neurasthénie, où le problématique et généralisante dont l’explication, confuse aussi, s’attribuait à une dégénération nerveuse et que finalement Freud désagrège jusqu'à arriver à la particularisation de la névrose obsessionnelle avec une étiologie psychique basée sur le conflit et la défense.
La función del objeto a y la lógica del análisis.
Authors: Mesa Clara Cecilia 
Published: January 2023

Hay, en el psicoanálisis, y en particular en aquella tradición inaugurada por Jacques Lacan, una necesidad lógica de mantener a aquél a la altura de las reflexiones de la época. Más específicamente, la tarea del psicoanálisis es verificar si su praxis puede unir, a su horizonte, la subjetividad propia de la lógica colectiva en la cual se halla inmerso. El texto La función del objeto a y la lógica del análisis es resultado de una investigación realizada en el curso de la Maestría: Psicoanálisis, Cultura y Vínculo Social, de la Facultad de Ciencias Sociales y Humanas de la Universidad de Antioquia. En dicha investigación, la autora se deja llevar por una pregunta sobre la angustia y sus manifestaciones en los sueños que, aunque precede al proyecto académico, opera como causa. La reflexión, poco a poco, avanza en la vía de articular la angustia a otros conceptos, como el deseo y el goce, y con ellos, a una noción esencial al pensamiento lacaniano: el objeto a. Este concepto es, al decir del propio Lacan, su aporte inédito al psicoanálisis. Si bien es enunciado oficialmente en 1963, está presente desde antes: da consistencia a un punto opaco en la obra de Sigmund Freud, sobre el objeto de la satisfacción pulsional como objeto irremediablemente perdido e imposible de recuperar.
¿Hay amor y sexualidad sin conflicto?
Authors: Aguilar Julián 
Published: January 2023

El presente ensayo da cuenta de un recorrido bastante amplio y a la vez puntual por los avatares y las complejidades propios de la vida amorosa de los seres humanos. En él se resalta la disarmonía entre los mismos, como una consecuencia apenas lógica de su naturaleza simbólica. Es por efecto del lenguaje que el sujeto traba relaciones con los otros, y es también por él que dichas relaciones «se traban» para dar cabida a los conflictos cotidianos que, pocas veces, son vividos como hechos triviales. Aquí, el amor y la sexualidad, articulados a la pulsión de muerte y al goce mortífero, constituyen el núcleo mismo de tales conflictos.
Juicio y realidad.
Authors: Gallo Héctor 
Published: January 2023

Este texto se ocupa de articular la noción de sujeto a conceptos esenciales de la metapsicología freudiana, tales como juicio, pulsión, realidad y represión. Estas nociones, relacionadas con el concepto lacaniano de forclusión, enfatizan el aspecto estructural del sujeto sobre la dimensión genética. Juicio y pulsión son los dos términos que de principio a fin se ponen en discusión, sin dejar de consignar la nueva dimensión del sujeto que la vertiente freudiana de la denegación pone en juego.