bluuebunny/crossref_metadata_2025_split huggingface dataset:
LARANGAN PELAKSANAAN ADAT MANDI KASAI PADA RITUAL PERKAWINAN MASYARAKAT LUBUKLINGGAU DI MASA PANDEMI COVID 19
Authors: Arafah Ricca Alfiatul , Tsani Wifa Lutfiani 
Published: March 2023

Sejak tahun 2020 Indonesia dilanda pandemi covid-19, pemerintah melalui Kementrian Agama (Kemenag) mengeluarkan Surat Edaran Nomor: P-004/DJ.III/Hk.00.7/04/2020 Tentang Pengendalian Pelaksanaan Nikah di Masa Darurat Bencana Wabah Penyakit Akibat Covid-19. Lalu bagaimana dengan ritual adat Mandi Kasai yang harus ditiadakan pada masa pandemi COVID-19 ini. Maka tulisan ini menganalisis mengenai larangan ritual adat Mandi Kasai pada upacara perkawinan masyarakat Lubuklinggau pada saat pandemi COVID-19. Hasil dari penelitian ini, perkawinan tetap dilaksanakan hanya dengan akad nikah tanpa adanya ritual adat. Tujuan diberlakukan larangan ini yaitu menunda perkawinan adat pada masa pandemi COVID-19 adalah perbuatan yang mulia karena menyelamatkan banyak jiwa. Segala hal yang lebih banyak menimbulkan mudharat harus dijauhi.
Competence aspects in forensic expertise of documents
Authors: Cataraga Olga , Alămoreanu Sorin , Petkovich Petr 
Published: March 2023

The technical expertise of documents, although it already seems to be a well-developed field, in the current stage faces many problems which need to be investigated. This especially concerns the limits of expert-examiners’ competences. Apart from the “classic” means of falsifying and counterfeiting documents, new ones constantly appear as the offenders gain new skills and equipment, which makes expertise much more complex.
In the present article, the authors attempt to discuss the limits of competences in the specialties of judicial expertise – code 6.01 (technical expertise of documents) and code 10.11 (examination of materials, documents, and writings). Exceeding one’s competence in carrying out the expertise cancels the evidence accumulated through scientific effort as well as entails disciplinary and often criminal liability of the expert-executor. The authors also propose an exemplary curriculum for training experts in forensic expertise of materials and documents and writings.
Value of Safety of Anticoagulant Therapy in Elderly Patient with Atrial Fibrillation and High Risk of Bleeding
Authors: Vorobyeva N. M. , Tkacheva O. N. 
Published: March 2023

The review article discusses the safety issue of anticoagulant therapy in elderly patients with atrial fibrillation and high risk of bleeding. An evidence base is presented demonstrating the high safety of rivaroxaban in patients over 80 years of age, with a high risk of bleeding and cardiovascular complications, the presence of comorbid pathology, geriatric syndromes and chronic kidney disease (including in combination with anemia). The problem of low adherence to treatment in elderly patients and the possibility of solving it were separately considered.
Microbiota and Cardiovascular Diseases: Mechanisms of Influence and Correction Possibilities
Authors: Gorbenko A. V. , Skirdenko Y. P. , Andreev K. A. , Fedorin M. M. , Nikolaev N. A. , Livzan M. A. 
Published: March 2023

The term "microbiota" refers to the microbial community occupying a specific habitat with defined physical and chemical properties and forming specific ecological niches. The adult intestinal microbiota is diverse. It mainly consists of bacteria of Bacteroidetes and Firmicutes types. The link between the gut microbiota and cardiovascular disease (CVD) is being actively discussed. Rapid progress in this field is explained by the development of new generation sequencing methods and the use of sterile gut mice in experiments. More and more data are being published about the influence of microbiota on the development and course of hypertension, coronary heart disease (IHD), myocardial hypertrophy, chronic heart failure (CHF) and atrial fibrillation (AF). Diet therapy, antibacterial drugs, pro- and prebiotics are successfully used as tools to correct the structure of the gut microbiota of the macroorganism. Correction of gut microbiota in an experiment on rats with coronary occlusion demonstrates a significant reduction in necrotic area. A study involving patients suffering from CHF reveals a significant reduction in the level of uric acid, highly sensitive C-reactive protein, and creatinine. In addition to structural and laboratory changes in patients with CVD when modifying the microbiota of the gut, also revealed the effect on the course of arterial hypertension. Correction of gut microbiota has a beneficial effect on the course of AF. We assume that further active study of issues of influence and interaction of gut microbiota and macroorganism may in the foreseeable future make significant adjustments in approaches to treatment of such patients.
Acute Coronary Syndrome during the Pandemic New Coronavirus Infection
Authors: Drapkina O. M. , Kravchenko A. Ya. , Budnevskiy A. V. , Kontsevaya A. V. , Ovsyannikov E. S. , Drobysheva E. S. 
Published: March 2023

The experience of managing patients with COVID-19 around the world has shown that, although respiratory symptoms predominate during the manifestation of infection, then many patients can develop serious damage to the cardiovascular system. However, coronary artery disease (CHD) remains the leading cause of death worldwide. The purpose of the review is to clarify the possible pathogenetic links between COVID-19 and acute coronary syndrome (ACS), taking into account which will help to optimize the management of patients with comorbid pathology. Among the body's responses to SARS-CoV-2 infection, which increase the likelihood of developing ACS, the role of systemic inflammation, the quintessence of which is a "cytokine storm" that can destabilize an atherosclerotic plaque is discussed. Coagulopathy, typical for patients with Covid-19, is based on immunothrombosis, caused by a complex interaction between neutrophilic extracellular traps and von Willebrandt factor in conditions of systemic inflammation. The implementation of a modern strategy for managing patients with ACS, focused on the priority of percutaneous interventions (PCI), during a pandemic is experiencing great difficulties due to the formation of time delays before the start of invasive procedures due to the epidemiological situation. Despite this, the current European, American and Russian recommendations for the management of infected patients with ACS confirm the inviolability of the position of PCI as the first choice for treating patients with ACS and the undesirability of replacing invasive treatment with thrombolysis.
Arrhythmic Mitral Valve Prolapse: New Menaces of the Known Disease
Authors: Kuzhel D. A. , Matyushin G. V. , Savchenko E. A. 
Published: March 2023

Mitral valve prolapse (MVP) has long been the subject of intense discussions regarding the prognosis and follow-up tactics. In most cases, this condition has a benign prognosis. However, recent autopsy and follow-up studies have shown risks of developing sudden cardiac death (SCD) in some subgroups of patients who have this clinical phenomenon. The proposed literature review uses the population of patients with MVP with the highest probability of developing life-threatening ventricular tachyarrhythmias. Patients with the presence of a complex of changes, including bicuspid MVP, negative T waves in the inferior and lateral leads on a standard 12-lead electrocardiogram (ECG), and a special anatomical phenomenon called mitral annular disjunction (MAD), are at high risk of developing ventricular ectopias and VSS. A reflection of the high risk of SCD in such patients is the increase of ventricular ectopy according to Holter monitoring. The presence of a bicuspid MVP and the MAD phenomenon, which is a separation of the line of attachment of the posterior mitral leaflet from the basal inferior wall segment towards the atrial wall, determines the presence of a special form of MVP, the so-called arrhythmogenic MVP. Hence, in most cases MVP has a benign prognosis. However, patients with the aforementioned ar- rhythmic MVP signs must be given particular attention and annual follow-up including ECG control, Holter monitoring and echocardiographic examination of the heart to reduce the risk of ventricular tachyarrhythmias and SCD development.
Atrial Fibrillation: a Marker or Risk Factor for Stroke
Authors: Tatarsky B. A. , Napalkov D. A. 
Published: March 2023

Atrial fibrillation (AF) is strongly associated with stroke risk, but an association by itself does not necessarily imply causation. The question remains whether AF is a risk factor for stroke and whether treatment that reduces the severity of AF will also reduce the burden of stroke. On the other hand, it is possible that AF is a risk marker associated with atrial insufficiency, in which structural and electrical atrial remodeling coexist, leading to the clinical manifestations of AF and the risk of stroke simultaneously. Atrial fibrillation and stroke are inextricably linked to the classic Virchow pathophysiology, which explains thromboembolism as blood stasis in a fibrillating left atrium. This concept has been reinforced by the proven efficacy of oral anticoagulants for the prevention of stroke in AF. However, a number of observations showing that the presence of AF is neither necessary nor sufficient for stroke cast doubt on the causal role of AF in vascular brain injury. The growing recognition of the role of atrial cardiomyopathy and the atrial substrate in the development of stroke associated with AF, as well as stroke without AF, has led to a rethinking of the pathogenetic model of cardioembolic stroke. A number of recent studies have shown that AF is a direct cause of stroke. Studies in which cardiac implantable devices have been used to collect data on pre-stroke AF do not appear to show a direct time relationship. The presence of AF is neither necessary nor sufficient for stroke, which casts doubt on the causal role of AF in cerebrovascular injury. Known risk factors for stroke in the presence of AF are also recognized risk factors for ischemic stroke, regardless of the presence of AF. The risk of stroke in patients with AF in the absence of risk factors differs little from that in patients without AF. This work is devoted to an attempt to answer the question whether AF is a marker or a risk factor for ischemic stroke.
Inflammatory Activity in Patients with Obstructive and Non-obstructive Coronary Artery Disease
Authors: Pakhtusov N. N. , Yusupova A. O. , Lishuta A. S. , Slepova O. A. , Privalova E. V. , Belenkov Yu. N. 
Published: March 2023

Aim. To study the levels of pro-inflammatory biomarkers in patients with obstructive and non-obstructive coronary artery disease (CAD), to identify possible differences for diagnosing the degree of coronary obstruction.Material and methods. The observational study included two groups of patients: with non-obstructive (main group, coronary artery stenosis <50%; n=30) and obstructive (comparison group, hemodynamically significant coronary artery stenosis according to the results of coronary angiography; n=30) CAD. The levels of interleukin-1β (IL-1β) and interleukin 6 (IL-6) were measured in plasma using enzyme immunoassay.Results. IL-6 levels were significantly higher in patients with obstructive CAD (p=0.006) than in patients with non-obstructive CAD. There were no significant differences in the level of IL-1β in both groups (p=0.482). When constructing the ROC curve, the threshold value of IL-6 was 26.060 pg/ml. At the level of IL-6 less than this value, CAD was diagnosed with hemodynamically insignificant stenoses of the coronary arteries.Conclusion. The results of this study confirm that in patients with different types of coronary artery lesions, there are differences in the activity of the inflammation process in the arterial wall. IL-6 was higher in the obstructive lesion group, and IL-1β levels did not differ between groups. Thus, it can be assumed that hemodynamically significant obstruction of the coronary arteries develops as a result of highly active inflammation of the vascular wall. Given the presence of a proven biological basis and the available data on the effectiveness of monoclonal antibodies to IL-1β, one cannot exclude their possible benefit in a cohort of patients with CAD and hemodynamically insignificant stenoses.
Arterial Hypertension and Severe COVID-19 in Hospitalized Patients: Data from a Cohort Study
Authors: Podzolkov V. I. , Bragina A. E. , Tarzimanova A. I. , Vasilyeva L. V. , Ogibenina E. S. , Bykova E. E. , Shvedov I. I. , Ivannikov A. A. , Druzhinina N. A. 
Published: March 2023

Aim. To assess the association of hypertension with the severe forms and fatal outcomes of Coronavirus disease 2019 (COVID-19).Material and Methods. This retrospective cohort study involved adult patients (≥18 years old), admitted to the University hospital №4 of Sechenov University (Moscow, Russia) between 08 April 2020 and 19 November 2020 with clinically diagnosed or laboratory-confirmed COVID-19. The cohort included 1637 patients. The primary outcome was all-cause in-hospital mortality. The secondary outcomes included intensive care unit admission (ICU) and invasive ventilation. Multiple logistic regression was performed to assess the independent association between risk factors and endpoints.Results. A total of 1637 patients were included in the study. 51.80% (n=848) of the subjects were males. The median age was 59.0 (48.0; 70.0) years and 55.90% (n=915) had pre-existing diagnosis of hypertension. Patients with hypertension had significantly more severe lung injury based on chest CT scan findings as well as lower oxygen saturation (SрO2). More of them were admitted to ICU and placed on invasive ventilation. The hypertension group also had higher mortality. Age, hypertension, glucose, C-reactive protein and decreased platelet count were independently associated with mortality, hypertension having the strongest association (OR 1.827, 95% CI 1.174-2.846, p=0.008). Age, hypertension, neutrophil count, platelet count, glucose, and CRP were independently associated with ICU admission, with hypertension having the strongest association (OR 1.595, 95% CI 1.178-2.158, p=0.002). Age, hypertension, glucose, CRP and decreased platelet count were independently associated with invasive ventilation, with hypertension having the strongest association (OR 1.703, 95% CI 1.151-2.519, p=0.008).Based on the multiple logistic regression models, odds of death, ICU admission, and invasive ventilation were higher in the hypertension group as compared to the group without hypertension.Conclusion. Hypertension can be an independent predictor of severe COVID-19 and adverse outcomes, namely death, ICU admission, and invasive ventilation in hospitalized patients.
Effect of Antibiotic Therapy on the Sensitivity of Etiological Diagnostic Methods in Patients with Infective Endocarditis after Surgery
Authors: Kotova E. O. , Moiseeva A. Yu. , Kobalava Zh. D. , Domonova E. A. , Pisaruk A. S. , Silveistrova O. Yu. , Kakhktsyan P. V. , Vladimirov V. V. 
Published: March 2023

Aim. Assessment of impact of the duration of preoperative antimicrobial therapy (AMT) on the sensitivity of microbiological examination and polymerase chain reaction (PCR) of blood/tissues of resected valves in operated patients with infective endocarditis (IE).Materials and methods. 52 operated patients with active IE were included prospectively (Duke criteria, 2015). All patients underwent microbiological examination of blood before admission to the cardiac surgery hospital, as well as parallel simultaneous microbiological examination and PCR of blood/tissues of excised valves, followed by Sanger sequencing. The duration of preoperative treatment was calculated from the first day of AMT according to IE diagnosis to the day of surgery.Results. The causative agent of IE was established in 84.6% (n=44) patients by means of complex etiological diagnosis. A significant decrease in the sensitivity of microbiological examination of venous blood was revealed when performed in the period before and after hospitalization to a surgical hospital (up 44.2% to 17.3%, p<0.05). When comparing microbiological examination of blood/tissues of resected valves and PCR of blood/tissues of resected valves, molecular biological methods demonstrated the greatest sensitivity, with a great advantage when examining the tissues of resected valves (17.3% and 19.2% vs. 38.5% and 75.0%, respectively; p<0.001). The microbiological examination of venous blood performed at an early date before admission to the cardiac surgery hospital was comparable in sensitivity to the PCR blood test performed at a later date after prolonged AMT, and significantly less sensitive in relation to the PCR of resected valve tissues [44.2% and 38.5% (p>0.05) vs. 75.0% (p<0.05)]. In course of AMT 1-28 days, there were comparable results of microbiological examination with PCR blood examination and significantly better results of PCR of resected valve tissues [31.0% and 34.5% and 41.4% (p>0.05) vs 72.4% (p<0.001), respectively], and with AMT ≥ 29 days, microbiological examination of any biological material was negative in all patients, and PCR of blood/tissues of resected valves retained high sensitivity (0% and 0% vs. 34.8% and 78.3%, respectively; p<0.01).Conclusion. Long-term preoperative AMT significantly reduced the sensitivity of microbiological examination of resected valve blood/tissue in operated patients with IE, whereas PCR of resected valve blood/tissue was highly sensitive even with preoperative AMT for more than 29 days.
Design and Implementation of a Nationwide Population-Based Longitudinal Survey of SARS-CoV-2 Infection in Spain: The ENE-COVID Study
Authors: Pastor-Barriuso Roberto , Pérez-Gómez Beatriz , Oteo-Iglesias Jesús , Hernán Miguel A. , Pérez-Olmeda Mayte , Fernández-de-Larrea Nerea , Molina Marta , Fernández-García Aurora , Martín Mariano , Cruz Israel , Sanmartín José L. , León-Paniagua José , Muñoz-Montalvo Juan F. , Blanco Faustino , Yotti Raquel , Pollán Marina 
Published: March 2023

Data System. The Spanish National Seroepidemiological Survey of SARS-CoV-2 (or ENE-COVID; SARS-CoV-2 [severe acute respiratory syndrome coronavirus 2] is the causative agent of COVID-19) was funded by the Spanish Ministry of Health, the Instituto de Salud Carlos III, and the Spanish National Health System. Data Collection/Processing. A stratified 2-stage probability sampling was used to select a representative cohort of the noninstitutionalized population of Spain. ENE-COVID collected longitudinal data from epidemiological questionnaires and 2 SARS-CoV-2 IgG antibody tests. From April 27 to June 22, 2020, 68 287 participants (77.0% of contacted persons) received a point-of-care test and 61 095 (68.9%) also underwent a laboratory immunoassay. A second follow-up phase was conducted between November 16 and 30, 2020. Data Analysis/Dissemination. Analyses use weights to adjust for oversampling and nonresponse and account for design effects of stratification and clustering. ENE-COVID data for research purposes will be available upon request from the official study Web page. Public Health Implications. ENE-COVID, a nationwide population-based study, allowed monitoring seroprevalence of antibodies against SARS-CoV-2 at the national and regional levels, providing accurate figures by gender, age (from babies to nonagenarians), and selected risk factors; characterizing symptomatic and asymptomatic infections; and estimating the infection fatality risk during the first pandemic wave. (Am J Public Health. 2023;113(5):525–532. https://doi.org/10.2105/AJPH.2022.307167 )
Design and Implementation of a National SARS-CoV-2 Monitoring Program in England: REACT-1 Study
Authors: Elliott Paul , Whitaker Matthew , Tang David , Eales Oliver , Steyn Nicholas , Bodinier Barbara , Wang Haowei , Elliott Joshua , Atchison Christina , Ashby Deborah , Barclay Wendy , Taylor Graham , Darzi Ara , Cooke Graham S. , Ward Helen , Donnelly Christl A. , Riley Steven , Chadeau-Hyam Marc 
Published: March 2023

Data System. The REal-time Assessment of Community Transmission-1 (REACT-1) Study was funded by the Department of Health and Social Care in England to provide reliable and timely estimates of prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection over time, by person and place. Data Collection/Processing. The study team (researchers from Imperial College London and its logistics partner Ipsos) wrote to named individuals aged 5 years and older in random cross-sections of the population of England, using the National Health Service list of patients registered with a general practitioner (near-universal coverage) as a sampling frame. We collected data over 2 to 3 weeks approximately every month across 19 rounds of data collection from May 1, 2020, to March 31, 2022. Data Analysis/Dissemination. We have disseminated the data and study materials widely via the study Web site, preprints, publications in peer-reviewed journals, and the media. We make available data tabulations, suitably anonymized to protect participant confidentiality, on request to the study’s data access committee. Public Health Implications. The study provided inter alia real-time data on SARS-CoV-2 prevalence over time, by area, and by sociodemographic variables; estimates of vaccine effectiveness; and symptom profiles, and detected emergence of new variants based on viral genome sequencing. (Am J Public Health. 2023;113(5):545–554. https://doi.org/10.2105/AJPH.2023.307230 )
Sex-specific associations between birthweight and objectively measured energy intake in adulthood
Authors: Guerithault Nicolas , Stinson Emma , De Baca Tomás Cabeza , Looker Helen , Votruba Susanne , Paolo Piaggi , Gluck Marci , Krakoff Jonathan , Chang Douglas 
Published: March 2023

Abstract
Background/Objectives: Lower birthweight has been previously identified as a risk factor for multiple chronic diseases which are also associated with poor diet. We sought to determine whether birthweight is related to objectively measured energy intake in adulthood. We hypothesized a negative association between birthweight and overall energy intake in adulthood.
Subjects/Methods: Healthy Indigenous American adults (n=65; age 33.2±8.0 years; female n=29; BMI 33.2±8.1 kg/m2) with measures of birthweight (mean 3465±376g; mean gestational age 40.1±1.2 weeks), ad libitum energy intake, and body composition were included. Three-day energy intake was measured using vending machines and categorized as high (≥45% kcal) or low in fat (<20% kcal) and as high in complex-carbohydrates (≥30% kcal), simple-sugars (≥30% kcal), or protein (≥13% kcal). Body composition was measured by DXA. General linear models assessed relationships between birthweight and intake, including age, sex, sex-birthweight interactions, fat mass index, and fat-free mass index as covariates.
Results: A birthweight-by-sex interaction was found such that birthweight was associated with energy intake negatively in males and positively in females (interaction p=0.04; simple slopes: male β=−64, female β= 93 kcal/day per 100 g birthweight). This pattern was evident in fat (interaction p=0.01; simple slopes: male β=−48, female β=42 kcal/day per 100g birthweight), protein (interaction p=0.02; simple slopes: male β=−5, female β=20 kcal/day per 100g birthweight), and high-fat/high-protein (interaction p=0.01; simple slopes: male β=−46, female β=45 kcal/day per 100g birthweight) consumption.
Conclusion: Birthweight was negatively associated with energy intake in adult males but was positively associated with energy intake in adult females.