bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diastolic ventricular function in persistent pulmonary hypertension of the newborn
Authors: Le Duc Kévin , Rakza Thameur , Baudelet Jean Benoit , Boukhris Mohamed Riadh , Mur Sébastien , Houeijeh Ali , Storme Laurent 
Published: June 2023

BackgroundPersistent pulmonary hypertension of the newborn (PPHN) is usually considered a consequence of impaired pulmonary circulation. However, little is known regarding the role of cardiac dysfunction in PPHN. In this study, we hypothesized that the tolerance for pulmonary hypertension in newborn infants depends on the biventricular function. The aim of this study is to evaluate biventricular cardiac performance by using Tissue Doppler Imaging (TDI) in an healthy newborn infants with asymptomatic pulmonary hypertension and in newborn infants with PPHN.MethodsRight and left cardiac function were investigated using conventional imaging and TDI in 10 newborn infants with PPHN (“PPHN”) and 10 asymptomatic healthy newborn infants (“asymptomatic PH”).ResultsSystolic pulmonary artery pressure (PAP) as assessed by TDI and the mean systolic velocity of the right ventricular (RV) free wall were similar in both groups. The isovolumic relaxation time of the right ventricle at the tricuspid annulus was significantly longer in the “PPHN” than in the “asymptomatic PH” group (53 ± 14 ms vs. 14 ± 4 ms, respectively; p &lt; 0.05). Left ventricular (LV) function was normal in both groups with a systolic velocity (S'LV) at the LV free wall groups (6 ± 0.5 cm/s vs. 8.3 ± 5.7 cm/s, p &gt; 0.05).ConclusionThe present results suggest that high PAP with or without respiratory failure is not associated with altered right systolic ventricular function and does not affect LV function in newborn infants. PPHN is characterized by a marked right diastolic ventricular dysfunction. These data suggest that the hypoxic respiratory failure in PPHN results, at least in part, from diastolic RV dysfunction and right to left shunting across the foramen ovale. We propose that the severity of the respiratory failure is more related to the RV diastolic dysfunction than the pulmonary artery pressure.
Serum soluble triggering receptor levels expressed on myeloid cells2 identify early acute kidney injury in infants and young children after pediatric cardiopulmonary bypass
Authors: Sun Mingwei , Yang Lijun , Zong Qing , Ying Liyang , Liu Xiwang , Lin Ru 
Published: June 2023

BackgroundAcute kidney injury (AKI) is a potential complication after cardiopulmonary bypass (CPB) of pediatric cardiac surgery and contributes to a certain amount of perioperative mortality. Serum soluble triggering receptor expressed on myeloid cells2 (sTREM2) is an inflammation-associated cytokine in circulation. Alterations of sTREM2 level have been reported in Alzheimer's disease, sepsis, and some other pathologic conditions. This study aimed to investigate the role of sTREM2 as a forecasting factor for AKI in infants and young children and other factors associated with early renal injury after pediatric CPB.MethodsA prospective cohort study with consecutive infants and young children ≤ 3 years old undergoing CPB from September 2021 to August 2022 was conducted in an affiliated university children's hospital. These patients were divided into an AKI group (n = 10) and a non-AKI group (n = 60). Children′s characteristics and clinical data were measured. Perioperative sTREM2 levels were analyzed with enzyme-linked immunosorbent assay (ELISA).ResultsIn children developing AKI, the sTREM2 levels significantly decreased at the beginning of CPB compared to the non-AKI group. Based on binary logistic regression analysis and multivariable regression analysis, risk-adjusted classification for congenital heart surgery (RACHS-1), operation time, and the s-TREM2 level at the beginning of CPB (AUC = 0.839, p = 0.001, optimal cut-off value: 716.0 pg/ml) had predictive value for post-CPB AKI. When combining the sTREM2 level at the beginning of CPB and other indicators together, the area under the ROC curve enlarged.ConclusionsOperation time, RACHS-1 score, and sTREM2 level at the beginning of CPB were independent prognosis factors of post-CPB AKI in infants and young children ≤ 3 years old. Decreased sTREM2 identified post-CPB AKI, and ultimately hampered the outcomes. Our findings indicated that sTREM2 may be a protective factor for AKI after CPB in infants and young children ≤ 3 years old.
Population pharmacokinetic analysis of transdermal granisetron in healthy Chinese and Caucasian volunteers
Authors: Li Jiayu , Hu Pei , Zhou Li , Nagahama Fumiko , Chen Rui 
Published: June 2023

Granisetron patches are a prolonged delivery transdermal system that is used to prevent Chemotherapy-induced nausea and vomiting (CINV). To date, no pharmacokinetics comparison between Chinese and Caucasian populations has been conducted for granisetron patches. This study focused on the ethnic differences in pharmacokinetics (PK) of granisetron transdermal delivery system (GTDS) between Chinese and Caucasians and the influence of demographic covariates on pharmacokinetics (age, weight, height, body mass index, sex). To achieve this, blood concentration data were collected from 112 Caucasian healthy subjects participating in four clinical trials and 24 Chinese healthy subjects from one clinical trial, after a single application of the granisetron transdermal delivery system. A nonlinear mixed-effects model method of Phoenix NLME software was used to establish a population pharmacokinetic (Pop PK) model for Caucasian subjects. Bootstrap and visual predictive check (VPC) were used to validate the model. Based on the analysis a one-compartment model with first-order absorption and a first-order elimination well described the PK characteristics of GTDS. The apparent systemic clearance was determined to be 31316.3 mL/h and the central compartment volume of distribution was 6299.03 L. None of the five covariates (age, weight, height, body mass index, and sex) included in the Pop PK were significant covariates affecting PK. The final Pop PK model was used to simulate the Caucasian blood concentration by applying the dosing regimen used for the Chinese population. Comparison of the simulated Caucasian PK data with observed clinical PK data from Chinese healthy subjects revealed no significant differences in the main parameters, AUClast and Cavg, between the two groups. These findings suggested that no dose adjustment was required when applied to the Chinese population. In conclusion, this Pop PK study comparing the transdermal patch in Chinese and Caucasian healthy subjects provided valuable insights for optimizing dosage across ethnicities.
HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4+ T cell activation in Sjögren’s syndrome
Authors: Yin Junhao , Xu Jiabao , Chen Changyu , Ma Xinyi , Zhu Hanyi , Xie Lisong , Wang Baoli , Shao Yanxiong , Zhao Yijie , Wei Yu , Hu Anni , Zheng Zhanglong , Yu Chuangqi , Fu Jiayao , Zheng Lingyan 
Published: June 2023

Introduction: Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by exocrine gland dysfunction, leading to loss of salivary function. Histological analysis of salivary glands from SS patients reveals a high infiltration of immune cells, particularly activated CD4+ T cells. Thus, interventions targeting abnormal activation of CD4+ T cells may provide promising therapeutic strategies for SS. Here, we demonstrate that Hect, uba, and wwe domain containing 1 (HUWE1), a member of the eukaryotic Hect E3 ubiquitin ligase family, plays a critical role in CD4+ T-cell activation and SS pathophysiology.Methods: In the context of HUWE1 inhibition, we investigated the impact of the HUWE1 inhibitor BI8626 and sh-Huwe1 on CD4+ T cells in mice, focusing on the assessment of activation levels, proliferation capacity, and cholesterol abundance. Furthermore, we examined the therapeutic potential of BI8626 in NOD/ShiLtj mice and evaluated its efficacy as a treatment strategy.Results: Inhibition of HUWE1 reduces ABCA1 ubiquitination and promotes cholesterol efflux, decreasing intracellular cholesterol and reducing the expression of phosphorylated ZAP-70, CD25, and other activation markers, culminating in the suppressed proliferation of CD4+ T cells. Moreover, pharmacological inhibition of HUWE1 significantly reduces CD4+ T-cell infiltration in the submandibular glands and improves salivary flow rate in NOD/ShiLtj mice.Conclusion: These findings suggest that HUWE1 may regulate CD4+ T-cell activation and SS development by modulating ABCA1-mediated cholesterol efflux and presents a promising target for SS treatment.
No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
Authors: Hartner Andrea , Dambietz Thomas , Cordasic Nada , Willam Carsten , Burzlaff Nicolai , Brötsch Martin , Daniel Christoph , Schiffer Mario , Amann Kerstin , Veelken Roland , Schley Gunnar , Hilgers Karl F. 
Published: June 2023

Introduction: We previously reported that malignant hypertension is associated with impaired capillary density of target organs. Here, we tested the hypothesis that stabilization of hypoxia-inducible factor (HIF) in a modified “preconditioning” approach prevents the development of malignant hypertension. To stabilize HIF, we employed pharmacological inhibition of HIF prolyl hydroxylases (PHD), that profoundly affect HIF metabolism.Methods: Two-kidney, one-clip renovascular hypertension (2K1C) was induced in rats; controls were sham operated. 2K1C rats received either intermittent injections of the PHD inhibitor ICA (2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetate) or placebo. Thirty-five days after clipping, the frequency of malignant hypertension was assessed (based on weight loss and the occurrence of characteristic vascular lesions). In addition, kidney injury was compared between all ICA treated versus all placebo treated 2K1C, regardless of the occurrence of malignant hypertension. HIF stabilization was evaluated by immunohistochemistry, and HIF target gene expression by RT-PCR.Results: Blood pressure was elevated to the same degree in ICA- and placebo-treated 2K1C compared to control rats. ICA treatment did not affect the frequency of malignant hypertension or the extent of kidney tissue fibrosis, inflammation, or capillary density. There was a trend towards higher mortality and worse kidney function in ICA-treated 2K1C rats. ICA increased the number of HIF-1α-positive renal tubular cell nuclei and induced several HIF-1 target genes. In contrast, expression of HIF-2α protein as well as HIF-2 target genes were markedly enhanced by 2K1C hypertension, irrespective of ICA treatment.Discussion: We conclude that intermittent PHD inhibition did not ameliorate severe renovascular hypertension in rats. We speculate that the unexpected strong renal accumulation of HIF-2α in renovascular hypertension, which could not be further augmented by ICA, may contribute to the lack of a benefit from PHD inhibition.
Research on equity of medical resource allocation in Yangtze River Economic Belt under healthy China strategy
Authors: Ya-qing Liu , Hao-ran Niu , Xiang-yang Tian , Mei-cheng Zhang , Feng Jiang , Yu-tong Qian , Jian-bo Cao 
Published: June 2023

ObjectiveThis study aimed to assess the fairness of medical resource allocation in the Yangtze River Economic Belt, based on the Healthy China strategy. It aimed to identify the issues with resource allocation fairness and provide optimization suggestions.MethodsTo assess the allocation fairness from a geographical population perspective, the study used the Health Resource Concentration and Entropy Weight TOPSIS methods. Additionally, the study analyzed the allocation fairness from an economic level angle, using the Concentration Curve and Concentration Index.ResultsThe study found that the downstream area had higher resource allocation fairness than the midstream and upstream areas. The middle reaches had more resources than the upper and lower reaches, based on population concentration. The Entropy Weight TOPSIS method found that Shanghai, Zhejiang, Chongqing, and Jiangsu had the highest comprehensive score index of agglomeration. Furthermore, from 2013 to 2019, the fairness of medical resource distribution gradually improved for different economic levels. Government health expenditure and medical beds were distributed more equitably, while general practitioners had the highest level of unfairness. However, except for medical and health institutions, traditional Chinese medicine institutions, and primary health institutions, other medical resources were mostly distributed to areas with better economic conditions.ConclusionThe study found that the fairness of medical resource allocation in the Yangtze River Economic Belt varied greatly based on geographical population distribution, with inadequate spatial accessibility and service accessibility. Although the fairness of distribution based on economic levels improved over time, medical resources were still concentrated in better economic areas. The study recommends improving regional coordinated development to enhance the fairness of medical resource allocation in the Yangtze River Economic Belt.
A Compact Planar Wi-Fi Antenna with Optimized Radiation Patterns for Small UAV Applications
Authors: Yang Ya-Lung , Lin Ding-Bing 
Published: June 2023

This paper proposes a compact planar Wi-Fi antenna with optimized radiation patterns for small uncrewed aerial vehicle (UAV) applications in both urban and open areas. It is suitable for mounting on the outermost side of the non-metallic wing of small UAVs. It has small dimensions of 16.5 mm (L) by 30.3 mm (W) by 1.6 mm (h), and the measured results of its prototype are in agreement with simulated data. Its impedance bandwidths over the two frequency ranges are 2.11 to 2.58 GHz and 5.06 to 7.5 GHz (S11≤-10 dB). At 5.8 GHz, it has stronger radiation below the small UAV to reduce interference from rare-use directions. Its maximum radiations, the directions of the maximum radiation in each elevation plane, are below the UAV and between 14° and 29° from the horizontal plane. At 2.4 GHz, it has quasi-omnidirectional radiation to ensure a stable link in all directions, and its maximum radiations are near the horizontal plane. The optimized radiation patterns at 5.8 and 2.4 GHz can provide more antenna gain when the small UAV flies farther in urban and open areas, respectively. In addition, it has good vertically polarized radiation for long-distance applications.
The Clinical Characteristics and Outcomes of Human Papillomavirus-Positive Nasopharyngeal Carcinoma in a Single-Institution Cohort
Authors: Awawda Muhammad , Salman Saeed , Billan Salem 
Published: June 2023

Background: Nasopharyngeal carcinoma (NPC) is a head and neck cancer more frequent among East Asian populations compared with Western populations. While much is known about human papillomavirus’s (HPV’s) role in oropharyngeal cancer (OPC), little is known about its prevalence and prognostic value in NPC. The aim of this study is to investigate the role of HPV in NPC treated with definitive radiotherapy at a single institution. Methods: A retrospective cohort analysis of patient’s medical records and HPV status treated for NPC in Rambam Health Care Campus (Rambam HCC). Immunohistochemical staining for p16 was used as a surrogate marker of HPV infection in the tumor cells. All specimens were stained and evaluated by pathologists at the referring center independently. Results: In total, 87 patients diagnosed with NPC were treated at Rambam HCC between 2005 and 2018. Seventy-four patients had accessible data on the disease’s clinical parameters and p16 status. In total, 10/74 (13.5%) had p16-positive staining in tumor cells; 75% were men and over 50% were smokers. The average age of diagnosis for the whole cohort was 48 years, being lower for p16-positive patients compared with p16-negative patients at 43 and 49 years old, respectively. A total of 84% of the patients had advanced disease of stage III and IV at presentation. Only 16% were diagnosed with stage I and II. Unlike the p16-negative group, the p16-positive group did not include any stage I or II disease. In univariate and multivariate analysis of overall survival rates, the age at diagnosis and the nodal spread status were the only statistically significant measures. P16 status was not found to be associated with survival. Conclusions: The HPV prevalence in NPC is nontrivial. p16-positive patients had significantly less nodal spread and tended to be younger. Both age and nodal status were significantly correlated with the survival, but P16 status was not prognostic. Further large-scale trials are needed to elucidate the role of HPV in NPC.
Risk of Death among Dialysis Patients Treated at Hospital-Affiliated versus Free-Standing Facilities in the United States
Authors: Zhang Lucy Y. , Amaral Sandra , McCulloch Charles E. , Grimes Barbara , Ku Elaine 
Published: June 2023

Key Points

Receipt of dialysis at hospital-affiliated facilities was associated with a higher risk of mortality compared with treatment at free-standing dialysis facilities.The differential mortality risk in free-standing versus hospital-affiliated facilities was more pronounced in non-Hispanic Black and Asian patients compared with other racial/ethnic groups.
Realization of Quantum Secure Direct Communication with Continuous Variable
Authors: Cao Zhengwen , Lu Yuan , Chai Geng , Yu Hao , Liang Kexin , Wang Lei 
Published: June 2023

With the progress of theoretical and applied technologies, the communication system based on the classical encryption is seriously threatened by quantum computing and distributed computing. A communication method that directly loads confidential information on the quantum state, quantum secure direct communication (QSDC), came into being for resisting security threats. Here, we report the first continuous-variable QSDC (CV-QSDC) experimental demonstration for verifying the feasibility and effectiveness of the CV-QSDC protocol based on Gaussian mapping and propose a parameter estimation for signal classification under the actual channels. In our experiment, we provided 4 × 10
2
blocks, where each block contains 10
5
data for direct information transmission. For the transmission distance of 5 km in our experiment, the excess noise is 0.0035 SNU, where SNU represents the unit of shot-noise units. The 4.08 × 10
5
bit per second experimental results firmly demonstrated the feasibility of CV-QSDC under the fiber channel. The proposed grading judgment method based on parameter estimation provides a practical and available message processing scheme for CV-QSDC in a practical fiber channel and lays the groundwork for the grading reconciliation.
Komunikasi Antarpersonal yang Efektif Pada Webinar Sosialisasi Bantuan Sosial Covid-19 di Dinas Sosial Provinsi Jawa Barat
Authors: Ainayah Almira 
Published: June 2023

Dinas Sosial Provinsi Jawa Barat merupakan provinsi yang paling banyak dalam menyalurkan bantuan sosial Covid-19 di Indonesia. Demi kelancaran kegiatan penyaluran bantuan sosial, dilakukan sosialisasi secara daring oleh Dinas Sosial Provinsi Jawa Barat kepada 27 Dinas Sosial Kabupaten/Kota di Jawa Barat. Sosialisasi daring tersebut disebut juga dengan webinar. Maka penelitian ini dilakukan untuk mengetahui seberapa besar efektivitas komunikasi antarpersonal antara pemateri dan peserta pada webinar dalam mensosialisasikan bantuan sosial Covid-19 di Dinas Sosial Provinsi Jawa Barat dengan menggunakan teori efektivitas komunikasi menurut Devito yang menyebutkan bahwa efektivitas komunikasi dilihat dari lima sikap yaitu sikap dalam berkomunikasi yaitu keterbukaan (openness), sikap empati (emphaty), sikap mendukung (supportiveness), sikap positif (positiveness), serta keseteraan (equality). Pada penelitian ini digunakan jenis penelitian deskriptif dengan pendekatan kuantitatif; sedangkan teknik sampling yang digunakan adalah teknik sampling jenuh dengan jumlah populasi sebanyak 27 orang yang merupakan peserta webinar sosialisasi tersebut; pada penelitian ini digunakan teknik analisis data statistik deskriptif. Hasil penelitian menunjukkan bahwa komunikasi antarpersonal dalam webinar telah efektif dengan nilai total persentase sebesar 77.28%; hal ini sesuai dengan persentase rata-rata keefektifan yang tinggi dari kelima sub variabel penelitian yaitu Keterbukaan sebesar 80.24%, Empati sebesar 75.61%, Sikap Mendukung sebesar 76.54%, Sikap Positif sebesar 78.39%, dan Kesetaraan sebesar 75.61%.
STRATEGI KOMUNIKASI PEMASARAN DALAM MEMBANGUN BRAND IMAGE POSITIF DIMASA PANDEMI COVID-19
Authors: Mutiasari Desy 
Published: June 2023

Desa Wisata Nglanggeran merupakan salah satu desa wisata yang meraih bannyak penghargaan baik di Indonesia maupun didunia. Hal ini tidak terlepas dari Strategi Komunikasi Pemasaran dalam membangun brand image positif terhadap Desa Wisata Nglanggeran, terutama dimasa pandemic Covid 19 ini. Dalam penelitian ini menggunakan analisis SOSTAC dan analisis SWOT. Menggunakan paradigma konstruktivism, pendekatan kualitatif, sifat penelitian deskriptif dan metode penelitian studi kasus. Hasil data yang diperoleh Analisis SOSTAC terhadap strategi komunikasi pemasaran pada Desa Wisata Nglanggeran, dilihat dari Situation Analisis Desa Wisata Nglanggeran dengan menggunakan analisis SWOT dari Desa Wisata Nglanggeran. Objective yang berkaitan dengan tujuan jangka Panjang dan pendek Desa Wisata Nglanggeran. Strategi komunikasi pemasarandengan menggunakan berbagai macam platform social media dalam menyebarluaskan informasi. Tactics dengan menggunakan social media dan word of mouth serta Action harus dijalankan dengan komitmen dan konsistensi. Control dengan menilai keberhasilan yang sudah dicapai oleh Desa Wisata Nglanggeran.
Fotografi Kehumasan, Media Komunikasi dan Media Dokumentasi di Media Sosial Instagram
Authors: Mulyono Tanto Trisno 
Published: June 2023

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MENINGKATKN HASIL BELAJAR IPS SUB TEMA KEBERAGAMAN BUDAYA BANGSAKU MELALUI MODEL STUDENT TEAM ACHIVEMENT DEVISION (STAD) DENGAN MEDIA GAMBAR KELAS IV SD
Authors: Damayanti Damayanti 
Published: June 2023

This study aims to improve students' learning outcomes in social science subjects Sub Theme of Cultural Diversity of Bangsaku Through Learning Model Student Team Achivemenet Devision With Picture Media Grade IV SD Negeri 4 Ambeua Kaledupa District. The design and model used in this study kemmis and Taggart model which includes planning, implementation, observation, reflection and re-planning and the type of research conducted by researchers is a type of class action research (PTK). From the evaluation of cycle I obtained data from 22 students, there were 13 students who obtained a KKM score of 65 or classically reached 59% and 9 students who did not complete 41% with an average score of 65.52 and a score weight of 1,443. while in cycle II classically student learning outcomes increased whereas out of 22 students, there were 20 students who obtained a KKM score of 65 or classically reached 91% and 2 students who did not meet the KKM 9% with an average score of 85.22 and a score weight achieved as much as 1,875. Based on the results of the study, it was concluded that the application of student team achievement team learning model can improve students' learning outcomes in social science subjects in grade IV of SD Negeri 4 Ambeua Kaledupa Regency.