bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wellbore Stability in a Depleted Reservoir by Finite Element Analysis of Coupled thermo-poro-elastic Units in an Oilfield, SW Iran
Authors: Pirhadi Alireza , Kianoush Pooria , Ebrahimabadi Arash , Shirinabadi Reza 
Published: August 2023

Abstract
Maintaining wellbore stability in depleted reservoirs is a critical problem. With production from hydrocarbon reservoirs, the pore pressure of the reservoir is reduced over time, and the reservoir is depleted since field development is one of the main purposes for oil companies. Heavy mud weight in depleted reservoir caused fracture due to reduced fracture gradient, and low mud weight caused blow out in high-pressure zone or well collapse due to shale beds that required high mud weight to prevent collapse. Considering geomechanics and coupled equilibrium equation, continuity equation, Hook’s law, compatibility equation, Darcy’s law, and thermal relation, the Thermo-poro-elastic equation was derived in this research. A finite element method has been developed to implement the fully coupled thermo-poro-elastic non-linear models. The finite element model was validated by comparing it to the available analytical solutions for the thermo-poro-elastic wellbore problems in shale. The non-linear thermal-poro-elasticity finite element model was used to analyze wellbore stability in a depleted reservoir during drilling. The numerical results showed that a decrease drilling fluid’s temperature (cooling) causes to increase in the potential for tensile failure and reduces the potential of shear failure. Due to the depletion reservoir, the potential of tensile failure increased than shear failure, so heating the drilling fluid could cause wellbore stability in the depleted reservoir. Furthermore, based on the numerical results, it may be concluded that the drilling fluid’s temperature is one of the important factors in the wellbore stability analysis in depleted reservoirs.
Impact of AI on Working Hours, Wage Rate and Global Economy
Authors: Jhaveri Saumya , Chauhan Anshika , Nizami Nausheen 
Published: August 2023

Abstract
Artificial Intelligence has a substantially increasing impact on the markets and economy. Implications on wage rates, working patterns, and lifestyles have also been marked as important factors. AI has the potential to extend the gap between inequality and unemployment. The framework discussed in this paper connects the dots between AI and the affecting factors. In a report published in 2018 by the World Economic Forum, it was projected that the advancement and implementation of AI would result in a net increase of 58 million new jobs by the year 2022. This estimation suggests that, despite concerns about the impact of AI on employment, the technology has the potential to generate a significant number of job opportunities globally.
The objective of this paper is to give an analytical explanation of artificial intelligence with respect to employment, working hours, and leisure in the short run and long run. The paper aims to bridge the gap between theoretical, mathematical and visual interpretations towards the trends of growing AI and its impact on the supply of labour in the market. It is an analytical research method using data from secondary sources. Time period of the study is from 2018 to 2022. Model one shows how the labour supply will behave when a firm is catering to the full demand by existing labour. It considers the situation of a firm with the extensive use of AI and limited work distribution amongst the labour which will lead to constant wage rates and decrease in number of working hours. Model two shows the impact of AI on the supply of labour of a firm which expects excess demand for goods than they can cater. Here, productivity will increase and therefore production will increase which will lead to more work done by labourers and an increase in their wage rate as there is more demand in the market. Given the speed of advancements, they will first have to work on investments and establishments of these technologies faster in order to complement their labor force and not substitute them. The impact of SDG 8 [Decent work and Economic growth] is also evaluated in the research. This paper analyzes the pace of development and impacts on labour markets in both the types of nations (developed and developing) and to study how the work and leisure patterns will change in low, medium, and high-skilled labour forces.
JEL: D24, D23, J01, J21, J24, J64.
Identifying and fixing in-plane positioning and stability issues on a microscope using nanoGPS OxyO scales
Authors: Acher Olivier , de Abreu Matheus Belisario , Grigoriev Alexander , de Bettignies Philippe , Vilotta Maxime , Nguyên Thanh-Liêm 
Published: August 2023

Abstract
Investigations of the in-plane positioning capabilities of microscopes using commercially available nanoGPS OxyO scales are presented. The scales have patterns that contain absolute position information, and nanoGPS software accurately determines the in-plane position from the scale images captured by the microscope camera. This makes in-plane positioning experiments simple and fast. We investigated different microscopy systems and found that positioning performance is a system issue that is not determined solely by the stage performance. In some cases, our experiments revealed software or hardware glitches that limited the positioning performance, which we easily fixed. We have also shown that it is possible to investigate vibrations using this approach and quantify their impact on image blurring. This is, for example, useful for experimentally determining the settling time after a stage movement.
Empirical Bayes Inference on the Weibull Distribution
Parameters Based on the Characteristic Prior
Authors: Maswadah M. 
Published: August 2023

Abstract
In this study, a new technique has been applied for eliciting the prior density function for the empirical Bayes by utilizing the characteristic function, which frees the Bayesian inference from subjectivity. The empirical Bayes estimates have been studied for the Weibull model parameters based on the characteristic prior and the informative gamma prior in terms of the mean squared errors and the mean percentage errors, via Monte Carlo simulations. The simulation results indicated that the empirical Bayes results based on the characteristic prior outperformed the ones based on the informative gamma prior. Finally, a numerical example is given to demonstrate the efficiency of the proposed priors.
High-pressure phase transitions of Fe-bearing orthopyroxene revealed by Raman spectroscopy
Authors: Li Luo , Zhang Xinyue , Yu Yingxin , Mao Zhu 
Published: August 2023

Abstract
Orthopyroxene is one of the dominant minerals in the Earth’s upper mantle. In this study, we used Raman spectroscopy to investigate the lattice vibration and phase transition of orthopyroxene with four different compositions using diamond-anvil cells up to 34 GPa at 300 K. Our orthopyroxene samples contain 0 (En100), 9% (En91Fs9), 11% (En86Fs11), and 21% (En74Fs21) Fe. At ambient conditions, the Raman modes exhibit a negative dependence on the Fe content, with the exception of the modes at ~850 and 930 cm–1. In contrast, these two Raman modes increase with increasing the Fe content. The phase transition from metastable α- to β-phase was observed at 12.9–15 GPa for samples with &lt;21 mol% Fe and varying Fe content has a minor effect on the phase transition pressure. Besides Fe, incorporation of 2–24 mol% Al can cause an increase in the phase transition pressure from 10–13 to 14–16 GPa. At 29–30.1 GPa, we observed the second apparent change in the Raman spectra for all four investigated samples. For Fe-bearing orthopyroxene, this change in the Raman spectra and frequency shift is associated with the phase transition from β- to γ-phase, whereas for En100, it should be caused by the change of coordination number of Si from 4 to 6 or the presence of α-popx phase. Using the obtained Raman frequency shifts, we calculated the Grüneisen parameters at high pressures. These parameters are useful for understanding the thermoelastic properties of orthopyroxene at high pressures.
Burst detection based on multi-time monitoring data from multiple pressure sensors in district metering areas
Authors: Zhang Xiangqiu , Wu Xuewei , Yuan Yongqin , Long Zhihong , Yu Tingchao 
Published: August 2023

Abstract

This research article presents a data-driven approach for detecting bursts in water distribution networks (WDNs). The framework uses spatiotemporal information from monitoring pressure and unsupervised learning model. This approach employs three stages: (1) benchmark dataset acquisition, (2) spatiotemporal information analysis, and (3) burst detection model construction. First, the benchmark datasets were the normal dataset initially obtained by the clustering algorithm. Second, spatiotemporal information features are extracted from multimoment time windows from multiple sensors, including the distance and shape features. Third, burst detection was performed based on the isolation forest technique. A WDN is used to evaluate the performance of the method. Results show that the method can effectively detect the burst.
A INEFICIÊNCIA DAS POLÍTICAS PÚBLICAS VOLTADAS AO IDOSO E A ADOÇÃO COMO ALTERNATIVA AO ABANDONO DELES
Authors: Thales de Araújo Martos Frederico , De Faria Matos José Antonio 
Published: August 2023

O aumento da expectativa de vida reconfigurou a sociedade, levando-a a um olhar mais cauteloso sobre o envelhecimento e a velhice, pois trazem consigo um processo de vulnerabilização do sujeito idoso, já que alteram características físicas, psíquicas, culturais e sociais. Cabe ao Estado, à sociedade e à família o dever de proteção dessas pessoas. O Estado, por meio de políticas públicas, não consegue proteger e atender a toda demanda que envolve os idosos, sobrando à família e à sociedade o dever de cuidar. Contudo, quando a família se esquiva de tal obrigação, acentua-se a condição de vulnerabilidade do idoso, pois fala-se em abandono. O Estatuto do Idoso prevê a possibilidade de colocação do idoso em família substituta nesses casos, como forma de garantir ao idoso melhores condições de vida e integração social e familiar. O convívio entre idoso e família substituta pode criar laços afetivos e, a depender do caso, uma verdadeira relação de adoção. Assim sendo é objetivo do presente artigo demonstrar a ineficiência das políticas públicas voltadas ao idoso, que leva à necessidade de se pensar em alternativas diante de sua vulnerabilidade, nos casos de abandono, como também discorrer sobre a adoção de idosos e o posicionamento do Judiciário diante tal pleito. Para isso parte-se de uma metodologia com abordagem qualitativa, método dedutivo e técnica bibliográfica, pesquisando a doutrina nacional, bem como documental, ao observar as normas que tratam sobre o cuidado com o idoso. Ao final, espera-se concluir se a colocação de idoso em família substitua especialmente com a adoção de idoso, enseja alternativa que permitirá o idoso gozar de direitos estabelecidos pela Constituição Federal, Estatuto do Idoso e demais leis que protegem esse público.
PLGA Nanoparticles as New Drug Delivery Systems in Leishmaniasis Chemotherapy: A Review of Current Practices
Authors: Valiallahi Alaleh , Vazifeh Zahra , Gatabi Zahra Rezanejad , Davoudi Maryam , Gatabi Iman Rezanezhad 
Published: August 2023

:
Although leishmaniasis is one of the most common parasitic diseases, its traditional
treatments suffer from some serious problems. To solve such issues, we can take advantage
of the effective nanoparticle-based approaches to deliver anti-leishmanial agents into
leishmania-infected macrophages either using passive targeting or using macrophagerelated
receptors. Despite the high potential of nanotechnology, Liposomal Amphotericin B
(AmBisome®) is the only FDA-approved nanoparticle-based anti-leishmanial therapy. In an
effort to find more anti-leishmanial nano-drugs, this 2011-2021 review study aimed to investigate
the in-vivo and in-vitro effectiveness of poly (lactic-co-glycolic acid) nanoparticles
(PLGA-NPs) in the delivery of some traditional anti-leishmanial drugs. Based on the results,
PLGA-NPs could improve solubility, controlled release, trapping efficacy, bioavailability,
selectivity, and mucosal penetration of the drugs, while they decreased resistance,
dose/duration of administration and organotoxicity of the agents. However, none of these
nano-formulations have been able to enter clinical trials so far. We summarized the data
about the common problems of anti-leishmanial agents and the positive effects of various
PLGA nano-formulations on reducing these drawbacks under both in-vitro and in-vivo conditions
in three separate tables. Overall, this study proposes two AmB-loaded PLGA with a
99% reduction in parasite load as promising nanoparticles for further studies.
Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of
Gastrointestinal Stromal Tumor
Authors: Yan Jingyi , Chen Xiaolei , Dong Qiantong , Lin Ji , Sun Xuecheng 
Published: August 2023

Introduction:
Recent studies have found that circular RNA is an abundant RNA species
that belongs to part of the competing endogenous RNA network (ceRNA), which was proven to
play an important role in the development, diagnosis and progress of diseases. However, the function
of circRNAs in imatinib resistance in Gastrointestinal stromal tumor (GIST) are poorly understood
so for. The present study aimed to screen and predict the potential circRNAs in imatinib resistance
of GIST using microarray analysis.

Methods:
We determined the expression of circular RNAs in paired normal gastric tissues (N),
primary GIST (gastrointestinal stromal tumor) tissues (YC) and imatinib mesylate secondary
resistance GIST tissues (C) with microarray and predicted 8677 dysregulated circular RNAs.

Results:
Compared with the YC group, we identified 15 circRNAs that were up-regulated and 8
circRNAs that were down-regulated in the C group. Gene ontology (GO) and Kyoto Encyclopedia
of Genes and Genomes (KEGG) pathway analysis indicated that these host linear transcripts that
differentially express circular RNAs are involved in many key biological pathways, predicting the
potential tumor-genesis and drug resistance mechanismrelated to HIF-1 pathway, later we draw the
cirRNA-miRNA-mRNA network involved in the HIF-1 pathway and found several dysregulated
circRNAs and the relationship between circRNA-miRNAs-mRNA, such as circRNA_06551,
circRNA_14668, circRNA_04497, circRNA_08683, circRNA_09923(Green, down-regulation)
and circRNA_23636, circRNA_15734 (Red, up-regulation).

Conclusion:
Taken together, we identified a panel of dysregulated circRNAs that may be potential
biomarkers even therapy relevant to the GIST, especially imatinib secondary resistance GIST.
Machine Learning-derived Multi-omics Prognostic Signature of
Pyroptosis-related lncRNA with Regard to ZKSCAN2-DT and Tumor
Immune Infiltration in Colorectal Cancer
Authors: Chen Jiamin , Jin Dan , Shao Liming , Wang Lingling , Zhou Liuzhi , Cai Jianting 
Published: August 2023

Background:
Colorectal cancer (CRC) has become the most prevalent gastrointestinal
malignant tumor, ranking third (10.2%) in incidence and second (9.2%) in death among all malignancies
globally. The most common histological subtype of CRC is colon adenocarcinoma
(COAD), although the cause of CRC remains unknown, as there are no valid biomarkers.

Methods:
A thorough investigation was used to build a credible biomolecular risk model based on
the pyroptosis-associated lncRNAs discovered for COAD prediction. Furthermore, Cibersort and
Tumor Immune Dysfunction and Exclusion (TIDE), the methods of exploring tumor immune infiltration,
were adopted in our paper to detect the effects of differential lncRNAs on the tumor microenvironment.
Finally, quantitative real-time polymerase chain reaction (qPCR), as the approach of
exploring expressions, was utilized on four different cell lines.

Results:
Seven pyroptosis-related lncRNAs have been identified as COAD predictive risk factors.
Cox analysis, both univariate and multivariate, revealed that the established signature might serve
as a novel independent factor with prognostic meaning in COAD patients. ZKSCAN2-DT was
shown to be considerably overexpressed in the COAD cell line when compared to normal human
colonic epithelial cells. Furthermore, ssGSEA analysis results revealed that the immune infiltration
percentage of most immune cells dropped considerably as ZKSCAN2-DT expression increased,
implying that ZKSCAN2-DT may play an important role in COAD immunotherapy.

Conclusion:
Our research is the first to identify pyroptosis-related lncRNAs connected with COAD
patient prognosis and to construct a predictive prognosis signature, directing COAD patient
prognosis in therapeutic interventions.
BH3 Mimetic Peptides: An Effective Strategy to Complement Anticancer
Therapy
Authors: Saraswathy Sundra Dhakshinamurthy , Mirunalini Arumugam , Karthikeyan Kandasamy , Premkumar Kumpati 
Published: August 2023

Abstract:
Apoptosis, a natural process of programmed cell death, is a promising therapeutic target
as the disruption of apoptosis evolves in many diseases including cancer. Several pieces of evidence
indicate that errors in apoptotic pathways result in the imbalance between cell proliferation
and death, allowing cells with genetic abnormalities to survive. The intrinsic and extrinsic pathways
of apoptosis utilize different caspases to execute the event of cell death through the cleavage
of hundreds of proteins. Proteins from the Bcl-2 family, a pivotal component of the mitochondrial
apoptosis pathway, activate the death signal either directly or indirectly involving mitochondrial
translocation of Bax/Bak, which are recognized critical elements in defective apoptosis. The majority
of chemotherapeutic drugs destroy cancer cells by activating the apoptotic machinery via
Bcl-2/Bax-dependent process and failure of which leads to an intrinsic chemoresistance. Recent insights
into the dynamic action of pro-survival Bcl-2 proteins in cancer pathogenesis and resistance
has set the stage for the development of small molecules as Bcl-2 antagonist and modulators of
apoptosis. The BH3-only proteins are vital inducers of the mitochondrial apoptosis mechanism that
operate either by assuming the functional activity of the proapoptotic Bcl-2 family members or by
impeding the antiapoptotic Bcl-2 proteins. Based on the structural interaction studies between the
proapoptotic and anti-apoptotic proteins, several synthetic peptides have been designed to functionally
mimic the BH3 domain, targeting directly the pro-survival Bcl-2 proteins. The “BH3-peptide
mimetics” a novel class of Bcl-2 protein antagonists essentially play an important role in the treatment
of malignancies as they are predicted to persuade non-receptor mediated programmed cell
death. This review summarizes the most promising BH3-peptide mimetic compounds that function
as selective antagonists of Bcl-2 proteins and would be effective in treating various cancers.
Overexpressed microRNA (miR)-382-3p promoted vascular remodeling via suppressing autophagy-related protein 7 (ATG7) in chronic thromboembolic pulmonary hypertension
Authors: Wang Kaifeng , Feng Xiaona , Yang Ting , Dang Bo , Wang Xiaodong 
Published: August 2023

Background:
This research has investigated the role of miR-382-3p in chronic thromboembolic pulmonary hypertension (CTEPH).

Methods:
Human pulmonary artery smooth muscle cells (hPASMCs) were treated with PDGF-BB to induce proliferation, and then transfected with miR-382-3p mimic, miR-382-3p inhibitor, ATG7 overexpression plasmid, and siATG7. MiR-382-3p, ATG7, VEGF, PCNA, p62, and LC3-Ⅱ/LC3-I levels were detected by qRT-PCR and Western blotting. Cell viability and migration were tested through CCK-8 and wound healing assays, respectively. Target genes of miR-382-3p were predicted by Targetscan and starBase, and pathway analysis was implemented through WebGestalt. The binding relationship between miR-382-3p and ATG7 was analyzed by the dual-luciferase reporter and RIP assays. A CTEPH model was constructed in rats with the treatment of miR-382-3p antagomir or agomir, and mean pulmonary artery pressure (mPAP) was measured. Lung tissue was observed through the HE staining assay.

Results:
MiR-382-3p level in hPASMCs was obviously upregulated with the increasing dose of PDGF-BB. MiR-382-3p mimic promoted yet miR-382-3p inhibitor suppressed hPASMC proliferation. MiR-382-3p directly targeted ATG7. ATG7 overexpression repressed hPASMC proliferation and migration, whereas siATG7 exerted the opposite effects. ATG7 overexpression partly neutralized the effects of miR-382-3p mimic on proliferation, migration, and autophagy-related proteins (ATG7, p62, and LC3-Ⅱ/LC3-I) in hPASMCs, whereas siATG7 partly offset the impacts of miR-382-3p inhibitor. MiR-382-3p antagomir reversed CTEPH-induced mPAP elevation, miR-382-3p upregulation, thickening of the pulmonary artery wall, and increased expressions of VEGF, PCNA, and autophagy-related proteins in rats, while miR-382-3p agomir potentiated these effects induced by CTEPH.

Conclusion:
Overexpressed miR-382-3p promotes vascular remodeling via ATG7 inhibition in CTEPH.
Wheel Running Adversely Affects Disease Onset and Neuromuscular
Interplay in Amyotrophic Lateral Sclerosis Slow Progression Mouse Model
Authors: Golini Elisabetta , Marinelli Sara , Pisu Simona , De Angelis Federica , Vacca Valentina , Rava Alessandro , Casola Irene , Laurenzi Gaia , Rizzuto Emanuele , Giuliani Alessandro , Musarò Antonio , Dobrowolny Gabriella , Mandillo Silvia 
Published: August 2023

Background:
Physical activity in Amyotrophic Lateral Sclerosis (ALS) plays a controversial
role. In some epidemiological studies, both recreational or professional sport exercise has
been associated to an increased risk for ALS but the mechanisms underlying the effects of exercise
have not been fully elucidated in either patients or animal models.

Methods:
To better reproduce the influence of this environmental factor in the pathogenesis of
ALS, we exposed SOD1G93A low-copy male mice to multiple exercise sessions at asymptomatic
and pre-symptomatic disease stages in an automated home-cage running-wheel system for about 3
months.

Results:
Repeated voluntary running negatively influenced disease progression by anticipating
disease onset, impairing neuromuscular transmission, worsening neuromuscular decline, and exacerbating
muscle atrophy. Muscle fibers and neuromuscular junctions (NMJ) as well as key molecular
players of the nerve-muscle circuit were similarly affected.

Conclusion:
It thus appears that excessive physical activity can be detrimental in predisposed individuals
and these findings could model the increased risk of developing ALS in predisposed and
specific professional athletes.