bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progesterone receptor membrane component 2 is critical for human placental extravillous trophoblast invasion
Authors: Yokouchi-Konishi Tae , Liu Yongjie , Feng Liping 
Published: September 2023

Abstract
Proper extravillous trophoblast invasion is essential for normal placentation and pregnancy. However, the molecular mechanisms by which cytotrophoblasts differentiate into extravillous trophoblast are unclear. We discovered that in the first-trimester placenta, progesterone receptor membrane component 2 was highly expressed in syncytiotrophoblast but significantly lower in extravillous trophoblast and cytotrophoblasts, indicating a divergent role for progesterone receptor membrane component 2 in trophoblast functions. We aim to examine the role of progesterone receptor membrane component 2 in extravillous trophoblasts invasion mediated by both intracellular and extracellular signals. Progesterone receptor membrane component 2 knockdown and overexpression cells were established in HTR8/SVneo cells, a first-trimester extravillous trophoblast-derived cell model, by transfection with small-interfering RNA or progesterone receptor membrane component 2 plasmids, respectively. Progesterone receptor membrane component 2 knockdown led to cellular morphological changes , enhanced trophoblast proliferation,invasion, and promoted tube formation. These effects were mediated by the activation of hypoxia-inducible factor 1alpha and an increased expression of vascular endothelial growth factor A. The culture supernatant collected from progesterone receptor membrane component 2 knockdown cells did not significantly affect extravillous trophoblast invasion compared to the controls, indicating that extracellular signaling did not robustly regulate extravillous trophoblast invasion in this study. In conclusion, attenuation of progesterone receptor membrane component 2 plays a role in placentation by promoting cell proliferation, invasion, and angiogenesis in extravillous trophoblasts via activation of hypoxia-inducible factor 1 alpha signaling. We thus identified a new function of progesterone receptor membrane component 2 and provide insights on understanding the mechanisms of trophoblast invasion.
An Intersectional Analysis of Technology-Facilitated Abuse: Prevalence, Experiences and Impacts of Victimization
Authors: Flynn Asher , Powell Anastasia , Hindes Sophie 
Published: September 2023

Abstract
Technology-facilitated abuse (TFA) is a growing problem. This article explores lifetime victimization experiences of TFA, presenting findings from the first study to establish a reliable national prevalence estimate for victimization in Australia, using a general adult population sample (n = 4,562) and 20 qualitative interviews with adults who have experienced TFA. Key findings include an overall high lifetime victimization prevalence (one in two Australians), high negative emotional impacts and severe mental distress among some marginalized groups. Our findings lend support for the utility of marginalization and intersectional theories in understanding the prevalence and negative impacts of TFA and address gaps in knowledge of how TFA victimization may differentially impact marginalized groups within an adult population. We argue that TFA research, policy and practice must be more attentive to intersecting and marginalized identities including and beyond gender.
Increased expression of SCARF genes favoring SARS-CoV-2 infection in key target organs in CKD
Authors: Carriazo Sol , Ribagorda Marta , Pintor-Chocano Aranzazu , Perez-Gomez Maria Vanessa , Ortiz Alberto , Sanchez-Niño Maria Dolores 
Published: September 2023

ABSTRACT

Background
Chronic kidney disease (CKD), especially diabetic CKD, is the condition that most increases the risk of lethal coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the underlying molecular mechanisms are unclear. SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs) regulate coronavirus cell entry and/or replication. We hypothesized that CKD may alter the expression of SCARF genes.

Methods
A literature search identified 34 SCARF genes of which we selected 21 involved in interactions between SARS-CoV/SARS-CoV-2 and host cells, and assessed their mRNA expression in target tissues of COVID-19 (kidneys, lungs, aorta and heart) in mice with adenine-induced CKD.

Results
Twenty genes were differentially expressed in at least one organ in mice with CKD. For 15 genes, the differential expression would be expected to favor SARS-CoV-2 infection and/or severity. Of these 15 genes, 13 were differentially expressed in the kidney and 8 were validated in human CKD kidney transcriptomics datasets, including those for the most common cause of CKD, diabetic nephropathy. Two genes reported to protect from SARS-CoV-2 were downregulated in at least two non-kidney target organs: Ifitm3 encoding interferon-induced transmembrane protein 3 (IFITM3) in lung and Ly6e encoding lymphocyte antigen 6 family member 6 (LY6E) in aorta.

Conclusion
CKD, including diabetic CKD, is associated with the differential expression of multiple SCARF genes in target organs of COVID-19, some of which may sensitize to SARS-CoV-2 infection. This information may facilitate developing therapeutic strategies aimed at decreasing COVID-19 severity in patients with CKD.
Royal Companies, Risk Management and Sovereignty in Old Regime France
Authors: Wade Lewis 
Published: September 2023

Abstract
Shortly after William of Orange arrived in Devon at the outset of the Glorious Revolution in 1688, Dutch troops stationed in Dartmouth seized the Amitié, a ship laden with marble purchased for the French court at Versailles. This seizure precipitated an extraordinary insurance dispute in Paris between two little-known royal companies: the Royal Insurance Company and the Royal Marble Company. This article analyses the fractious dispute and the companies at its heart. In so doing, it reflects on the dispute as a product of the French state’s broader exploitation of companies as tools of risk management: the state leveraged private capital in order to spread the risks of its virulently anti-Dutch commercial policy. Yet the dispute also exposed the ambiguities of war and peace in seventeenth-century thought and practice. In justifying their refusal to pay out on the insurance policy they had signed on the Amitié, the Royal Insurance Company’s directors suggested that an insurer could decide unilaterally that France was in a state of war, thereby triggering a contractual clause that would shift the onus back onto the policyholder. Although Louis XIV himself stepped in to defuse the dispute at its most contentious moment, the state proved unable to respond to the challenge posed to its sovereignty, with significant consequences for the French insurance industry and maritime commerce up to the end of the Old Regime.
Using machine learning to predict bleeding after cardiac surgery
Authors: Hui Victor , Litton Edward , Edibam Cyrus , Geldenhuys Agneta , Hahn Rebecca , Larbalestier Robert , Wright Brian , Pavey Warren 
Published: September 2023

Abstract

OBJECTIVES
The primary objective was to predict bleeding after cardiac surgery with machine learning using the data from the Australia New Zealand Society of Cardiac and Thoracic Surgeons Cardiac Surgery Database, cardiopulmonary bypass perfusion database, intensive care unit database and laboratory results.

METHODS
We obtained surgical, perfusion, intensive care unit and laboratory data from a single Australian tertiary cardiac surgical hospital from February 2015 to March 2022 and included 2000 patients undergoing cardiac surgery. We trained our models to predict either the Papworth definition or Dyke et al.’s universal definition of perioperative bleeding. Our primary outcome was the performance of our machine learning algorithms using sensitivity, specificity, positive and negative predictive values, accuracy, area under receiver operating characteristics curve (AUROC) and area under precision–recall curve (AUPRC).

RESULTS
Of the 2000 patients undergoing cardiac surgery, 13.3% (226/2000) had bleeding using the Papworth definition and 17.2% (343/2000) had moderate to massive bleeding using Dyke et al.’s definition. The best-performing model based on AUPRC was the Ensemble Voting Classifier model for both Papworth (AUPRC 0.310, AUROC 0.738) and Dyke definitions of bleeding (AUPRC 0.452, AUROC 0.797).

CONCLUSIONS
Machine learning can incorporate routinely collected data from various datasets to predict bleeding after cardiac surgery.
Worldwide trends in mortality for hypertensive heart disease from 1990 to 2019 with projection to 2034: data from the Global Burden of Disease 2019 study
Authors: Lu Wen-long , Yuan Jian-hui , Liu Ze-ye , Su Zhan-Hao , Shen Yu-Chun , Li Shou-jun , Zhang Hao 
Published: September 2023

Abstract

Aims
This study aims to analyse the worldwide trends in hypertensive heart disease (HHD) mortality and associations with age, period, and birth cohort and predict the future burden of HHD deaths.

Methods and results
Mortality estimates were obtained from Global Burden of Disease 2019 study. We used age–period–cohort (APC) model to examine the age, period, and cohort effects on HHD mortality between 1990 and 2019. Bayesian APC model was utilized to predict HHD deaths to 2034. The global HHD deaths were 1.16 million in 2019 and were projected to increase to 1.57 million in 2034, with the largest increment in low- and middle-income countries (LMICs). Between 1990 and 2019, middle/high-middle socio-demographic index (SDI) countries had the largest mortality reductions (annual percentage change = −2.06%), whereas low SDI countries saw a lagging performance (annual percentage change = −1.09%). There was a prominent transition in the age distribution of deaths towards old-age population in middle/high-middle SDI countries, while the proportion of premature deaths (aged under 60 years) remained at 24% in low SDI countries in 2019. Amongst LMICs, Brazil, China, and Ethiopia showed typically improving trends both over time and in recent birth cohorts, whereas 63 countries including Indonesia, the Philippines, and Pakistan had unfavourable or worsening risks for recent periods and birth cohorts.

Conclusion
The HHD death burden in 2019 is vast and is expected to increase rapidly in the next decade, particularly for LMICs. Limited progress in HHD management together with high premature mortality would exact huge human and medical costs in low SDI countries. The examples from Brazil, China, and Ethiopia suggest that efficient health systems with action on improving hypertension care can reduce HHD mortality effectively in LMICs.
Leg-focused high-weight resistance training improves ventricular stroke volume, exercise capacity and strength in young patients with a Fontan circulation
Authors: Scheffers Linda E , Helbing Willem A , Pereira Thomas , Utens Elisabeth M W J , Dulfer Karolijn , Hirsch Alexander , Koopman Laurens P , van den Berg Linda E 
Published: September 2023

Abstract

Aims
Effective therapy to improve exercise capacity in Fontan patients is lacking. Leg-focused high-weight resistance training might augment the peripheral muscle pump and thereby improve exercise capacity.

Methods and results
This randomized semi-cross-over controlled trial investigated the effects of a 12-week leg-focused high-weight resistance training plus high-protein diet, on (sub)maximal exercise capacity, cardiac function (assessed with cardiovascular magnetic resonance), muscle strength, and quality of life in paediatric Fontan patients. Twenty-eight paediatric Fontan patients were included, 27 patients, (median age 12.9 [10.5–15.7]), and successfully completed the programme. Peak oxygen uptake (PeakVO2) at baseline was reduced [33.3 mL/kg/min (27.1–37.4), 73% (62–79) of predicted]. After training PeakVO2/kg and Peak workload improved significantly with +6.2 mL/kg/min (95%CI: 3.4–9.0) (+18%) P &lt; 0.001 and +22 Watts (95%CI: 12–32) (+18%) P &lt; 0.001, respectively, compared to the control period. Indexed single ventricle stroke volume increased significantly [43 mL/beat/m2 (40–49) vs. 46 (41–53), P = 0.014], as did inferior vena cava flow [21 mL/beat/m2 (18–24) vs. 23 (20–28), P = 0.015], while superior vena cava flow remained unchanged. The strength of all measured leg-muscles increased significantly compared to the control period. Self-reported quality of life improved on the physical functioning and change in health domains of the child health questionnaire, parent-reported quality of life improved the bodily pain, general health perception, and change in health domains compared to the control period.

Conclusion
In a relatively large group of 27 older Fontan children, 12-weeks of leg-focused high-weight resistance training improved exercise capacity, stroke volume, (sub)maximal exercise capacity, muscle strength, and domains of quality of life.

Registration
International Clinical Trials: Trial NL8181.
E-health literacy and associated factors among Korean adults during the COVID-19 pandemic: age-group differences
Authors: Park So-Young , Chung Soondool 
Published: September 2023

Abstract
The purpose of this study was to compare the mean scores of e-health literacy, health information, social relationships, and psychological status between younger, middle-aged, and older Korean adults during the COVID-19 pandemic and to identify the factors associated with e-health literacy as well as the moderating effect of age on the association between health information factors and e-health literacy. We used a cross-sectional survey of 2400 Korean adults aged 20 years or older residing in Seoul. Descriptive statistics, ANOVA, chi-square test, and hierarchical multiple regression analyses were used to analyze the data. Findings demonstrated an age-group difference in the mean score of e-health literacy with the older group having lower e-health literacy than the other groups. Health information, social support, and COVID-19-related anxiety were associated with e-health literacy and a moderating effect of age on the association between sources of health information and e-health literacy was also identified among the three age subgroups. This study emphasizes the importance of identifying e-health-related risk factors leading to health disparities between age groups.
The Lived Experience of Breast Cancer Patients during the COVID-19 Pandemic
Authors: Counselman-Carpenter Elisabeth , Williams Joyce 
Published: September 2023

Abstract
This article seeks to understand the impact of the COVID-19 pandemic on women currently undergoing treatment for breast cancer. As part of a mixed-methods study of 69 women who have or currently live with breast cancer, 27 participants opted into a Phase II semistructured interview to further discuss their experiences of emotional coping during the treatment process, beliefs about therapy, and the impact of COVID-19 on their emotional experience during treatment. Thematic narrative analysis was used to identify common themes. Participants shared about the unique stressors and impact of the COVID-19 pandemic during their treatment and how it complicated the already emotional experience of coping with cancer. Five identified themes include (1) logistical impact of COVID-19 and its effects on accessing medical care, (2) concerns related to accessing emotional support, (3) emotional reactions to battling breast cancer while living through a global pandemic, (4) ways in which loss was experienced, and (5) benefits to technology-based psychoeducation and social supports that were identified during the pandemic. COVID-19 had a significant impact on those currently in treatment for breast cancer including increasing fear, decreasing social support, and increased logistical challenges. Changes to psychotherapeutic treatment protocols to include technologically enhanced psychological support during treatment and digitally based psychoeducation curriculum are warranted.
Digital tools as experts in international peace and security
Authors: Lobato Luisa Cruz , Santos Victoria 
Published: September 2023

Abstract
Over the past decades, knowledge about peace and security has become increasingly mediated and co-produced with and through digital objects such as databases, indicators, apps, big data and data analysis algorithms. Only recently has the literature begun to recognize this. This article addresses the gap in the literature by exploring the centrality of digital objects' design in their emergence as experts in relation to international peace and security practices. By centering the politics of design, we contribute to broader debates on the effects of technology for who/what is considered an expert in contemporary international policy. Through a material-semiotic analysis of the UN SanctionsApp and the Security Assistance Monitor database, and semi-structured interviews with creators and users, we show how the normative goal of inclusion is inscribed into digital artifacts and translated into use. These cases were selected based on their inclusion of relevant state and nonstate actors into policy decisions, and our findings suggest that usage and material infrastructures play an important role in how this purpose is advanced. We shed light onto how digital expert objects produce actionable knowledge via the web of relations implicated in their production and highlight the importance of practitioners' participation in the making of such objects.
Psychiatric Diagnoses, Medication, and Service Use Among Patients Who Receive Emergency Care for Inflammatory Bowel Diseases
Authors: He Jimmy Z , Hirschtritt Matthew E , Wei Julia , Ramalingam Nirmala D , Kahane Shellie M , Velayos Fernando S , Hassid Benjamin G 
Published: September 2023

Lay Summary
This study examined relative psychiatric burden among patients who presented to the emergency department once or more than once for inflammatory bowel disease visits. Results highlight the need for integration of psychiatric and gastrointestinal care among high-risk inflammatory bowel disease patients.
The effect of quota portfolio composition on optimal harvest strategy and profitability in a multi-species fishery
Authors: Alizadeh Ashrafi Tannaz , Hermansen Øystein , Kvamsdal Sturla F 
Published: September 2023

Abstract
The benefits of individual vessel quota (IVQ) management in terms of improved harvest strategy and profitability are well recognized, but there is less focus on how different components of a quota portfolio can influence decisions underlying the effort allocation and profit-maximizing behaviour of fishers. Variations in the components of the quota portfolio may create economic incentives that alter the optimal harvest strategy and profitability. Thus, we study the potential impact of different components of quota portfolio on the intra-annual harvest strategy and profitability in two segments of the Norwegian bottom trawl fleet. By developing a vessel-based spatio-temporal bioeconomic framework, we demonstrate and compare adopted harvest strategies and accrued profits for small and large trawl vessels under three scenarios regarding restrictive quotas in codfish fishery. Our analysis confirms that alternations in the components of the quota portfolio influence the spatio-temporal dynamics of the fishing effort for small and large trawl vessels in different ways, probably due to the differences in vessel-specific characteristics. We also demonstrate that the differences in profit between small and large vessels in part depend on the overall size of the quota portfolio. The economies of scale in the trawl industry are being eroded as the shares of higher-priced species in the quota portfolio decreases. The benefits of economies of scale cannot be reaped as trawlers respond to the reduction in profit by redirecting effort from offshore areas of the Arctic to nearshore waters or staying ashore. Likewise, having small quotas of high-priced species reduces the effectiveness of the IVQ system in meeting management objectives, and could in some cases undermine sustainability outcomes. Our results also demonstrate that both the intensity with which fishers react to the fluctuations in market price levels and fishers’ perceptions of location attractiveness are influenced by the components of the quota portfolio.
Community health workers to reduce unmet surgical needs in an urban slum in India: an implementation study
Authors: Vora Kranti , Salvi Falguni , Saiyed Shahin , Desai Chinmayi , Joshi Rajendra , Buch Keyur , Mavalankar Dileep , Jindal Rahul M 
Published: September 2023

Abstract

Background
The Surgical Accredited & Trained Healthcare Initiative (SATHI) project demonstrates how community healthcare workers (CHWs) with merely 8 y of formal schooling and training for a short period can reduce unmet surgical needs.

Methods
A pilot study was carried out in the slums of a metropolitan city in India to know the effectiveness of a SATHI in reducing the burden of unmet surgical needs. In total, 12 730 people from 3000 households were included in the study for a duration of 6 months.

Results
We found 10% surgical needs (n=293) out of which 57% had unmet surgical needs. Out of total surgical needs, about half of the needs were cataract and abdominal, followed by extremities and chest conditions. SATHIs were able to convert 99 patients (60%) from unmet to met needs, who underwent surgery/treatment. The conversion from unmet to met among all surgery needs was highest for abdominal conditions (29%) followed by cataracts (17%).

Conclusions
SATHIs with short training can reduce the burden of unmet surgical needs. SATHIs were able to convert a significant proportion of unmet to met needs by trust building, facilitating access to healthcare and ensuring post-operative adherence. Scaling up could help in the achievement of equitable healthcare across India.
A Systematic Review and Meta-Analysis on the Efficacy of Virtual Reality Pedestrian Interventions to Teach Children How to Cross Streets Safely
Authors: Morgan Casie H , Stager Lindsay M , Schwebel David C , Shen Jiabin 
Published: September 2023

Abstract

Objective
Over 7,000 American children die from pedestrian injuries annually, and pedestrian injury ranks among the top 5 causes of unintentional child death. Prevention efforts are multifaceted. One strategy, use of virtual reality (VR) to teach children to cross streets, is of growing interest to public health practitioners. The present study is a systematic review and meta-analysis that examined the efficacy of using VR to teach children pedestrian safety.

Methods
Following PRISMA guidelines, searches among 7 databases were completed, followed by abstract/full-text screening and data extraction. Hedge’s g was computed for the effect sizes of 3 outcomes: pedestrian knowledge, pedestrian-relevant cognition (attention to traffic, time to contact, start delay), and pedestrian behaviors (safe crossings, unsafe crossings). Risk of bias was assessed using Cochrane guidelines. Meta-regression analyses and subgroup analyses were conducted including 3 moderators: age, sex, and immersion level.

Results
A total of 20 studies, reported in 24 articles, were included in the qualitative analysis. Meta-analysis of the 12 studies with sufficient quantitative data available showed a statistically significant medium effect of VR safety interventions on child pedestrian knowledge and behavior. Mixed results emerged for the effect of VR safety interventions on children’s pedestrian-relevant cognition. Age and sex moderated the effect of VR training on pedestrian knowledge.

Conclusions
This synthesis of the literature on pediatric VR pedestrian safety interventions suggests an overall beneficial impact of VR interventions to teach children how to cross streets safely. Efforts should continue to develop and disseminate effective VR interventions.

Registration ID
CRD42022309352