bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOSIALISASI CiPOM (CEK KLIKK BPOM) KOSMETIK PADA SISWA SISWI SMA NEGERI 4 JEMBER
Authors: Alishlah Tanfidz , Ulfa Evi Umayah , Ningsih Indah Yulia 
Published: July 2023

Industri kosmetik Indonesia saat ini sangat berkembang pesat. Seiring dengan meningkatnya pasar kosmetik di Indonesia, semakin banyak oknum yang mengambil keuntungan dengan memproduksi kosmetik ilegal mengandung bahan berbahaya yang sangat merugikan konsumen karena dapat membahayakan kesehatan. Berdasarkan data, 70% konsumen pengguna kosmetik di Indonesia yaitu pada usia remaja. Para remaja yang baru mulai mengenal kosmetik sering kali mudah terpengaruh dan tidak memiliki pengetahuan tentang keamanan produk kosmetik. Salah satu upaya yang dilakukan adalah sosialisasi CiPOM yaitu Cek KLIKK (Kemasan, Label, Izin edar, Kegunaan, dan Kadaluarsa) BPOM pada kosmetik. Kegiatan ini bertujuan meningkatkan edukasi masyarakat di kalangan remaja tentang kosmetik. Metode kegiatan pengabdian ini menggunakan metode ceramah dan diskusi secara daring menggunakan Zoom meeting. Peserta kegiatan ini adalah siswa-siswa Kelas 2 SMA Negeri 4 Jember. Hasil post-test peserta yaitu 90% dari total peserta mendapat nilai ≥ 70, serta mengalami peningkatan akurasi ketepatan dengan nilai rata-rata dari 38,4% saat pre-test menjadi 75,5% saat post-test yang menunjukkan bahwa peserta memahami materi sosialisasi yang telah disampaikan. Kegiatan ini dapat dikatakan berhasil, dilihat dari indikator keberhasilan yang telah dicapai, tingkat kehadiran, dan keaktifan peserta. Kegiatan sosialisasi ini diharapkan dapat terus dilaksanakan secara rutin mengingat masih rendahnya tingkat pengetahuan remaja sebagai konsumen produk kosmetik Adanya kegiatan pengabdian masyarakat ini diharapkan mampu memberikan pemahaman, pengetahuan, dan peserta mampu mengaplikasikan serta menyebarluaskan informasi untuk memilih kosmetik yang aman.
CASE SIMULATION AS AN EFFORT FOR EARLY DETECTION AND EMERGENCY MANAGEMENT IN STROKE ATTACKS
Authors: Widianto Eko Prasetya , Maisyaroh Arista , Kurnianto Syaifuddin 
Published: July 2023

Stroke is the second leading cause of death worldwide and the leading cause of long-term disability. Stroke survivors are at high risk for recuurent stroke and long-term disabling sequelae. Stroke causes reduced or oven loss of function that occurs in these tissues, because a stroke attacks brain function without other causes. Patients with stroke will experience disturbances. Post stroke sensory and motor disturbances result in balance disturbances including muscle weakness, decreased soft tissue flexibility, and impaired motor and sesnsory control. There fore it is necessary to have a simulation that is socialized to the community. This services aims to improve skills through the role of the community, especially the elderly, in supporting produktivity by providing solutions that can be implemented, including increasing community knowledge through counseling and early detection and early management of stroke. The methods used in community service are field learning practice methods and learning practicums to improve the quality of health through lectures, discussions, and early detection. This activity is carried out with health counseling about emergency management of stroke attacks. Efforts to increase community knowledge and skills in overcoming stroke attacks can be carried out with counseling and early detection, especially in the elderly. This simulation activity is expected to increase knowladge so that it can reduce victims in the event of a stroke.
PENGEMBANGAN USAHA BAGIAK (JAJANAN KHAS ETNIS OSING) MELALUI PRODUKSI BAGIAK KAYA SERAT DAN APLIKASI BUSSINES MODEL CANVAS (BMC)
Authors: Herlina Herlina , Utami Elok Sri , Fauziah Riska Rian , Lindriati Triana , Harsita Pradiptya Ayu , Wiyono Andi Eko , Indraningrat Ketut 
Published: July 2023

Kue bagiak merupakan kue tradisional khas Banyuwangi yang umumnya berbahan baku pati garut dan gula sehingga tidak mempunyai nilai fungsional kesehatan. Upaya untuk meningkatkan nilai fungsional kue bagiak perlu ditambahkan bahan lain seperti mocaf dan kelapa parut kering yang memiliki kandungan serat tinggi. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk mensosialisasikan cara pembuatan kue bagiak kaya serat dan meningkatkan pendapatan masyarakat pedesaan, khususnya UD. Waining Jaya sebagai mitra kegiatan melalui penjualan bagiak kaya serat. Metode kegiatan yang digunakan adalah melalui metode tepat guna yang mudah diadopsi oleh masyarakat, yaitu demo pembuatan bagiak kaya serat, pelatihan penggunaan alat pencetak bagiak, dan aplikasi penggunaan BMC (Bussines Model Canvas) untuk mempermudah pengelolan usaha bagiak kaya serat. Hasil kegiatan menunjukkan bahwa: 1) masyarakat desa Gintangan kecamatan Blimbingsari, khususnya UD. Waining Jaya sangat antusias menerima rekomendasi produk yang dikembangkan pelaksana kegiatan; 2) metode dan komposisi pembuatan bagiak kaya serat, yaitu proporsi mocaf 50g dan kelapa parut kering 25g dengan karakteristik nilai kecerahan warna (lightness) 71,31, baking loss 15,37%, kadar air 2,73%, kadar lemak 13,87%, total serat 10,63% dan dengan uji organoleptik untuk kesukaan warna 4,73, aroma 4,70, rasa 4,60, keremahan 4,83, serta kekerasan 4,87; 3) pembuatan alat pencetak bagiak semi otomatis; dan 4) penyusunan BMC(Business Model Canvas) usaha kue bagiak.
A Review of Indonesian Nationality Law
Authors: Prameswari Zendy Wulan Ayu Widhi , Agustin Erni , Felicia Stefania Arshanty 
Published: July 2023

Stateless people are often denied access to the same rights and services as citizens. Furthermore, statelessness is often the result of discrimination against women, an issue that SDGs aim to address. This paper analyses how the Indonesian Nationality Law protects children at risk of statelessness. It also raises some legal challenges when applying the law with regards to the country's SDG achievements. Discussion of the nationality law in Indonesia is not new, but scrutinising it in connection to Indonesia's achievement of SDGs has yet to be carried out by other authors. This paper is legal research using statute and conceptual approaches. The study shows that by reforming its nationality law, the Indonesian Government has allowed women to confer their nationality on their children equally with men. However, some challenges related to the implementation of this new law and its regulations still have the potential to cause issues of discrimination and statelessness for Indonesian children, which relates strongly to the issues addressed by SDGs. Additionally, this paper will be useful for the development of constitutional law, especially human rights and nationality laws in Indonesia.

Keywords: Children’s Rights, Indonesian Nationality Law, Non-discrimination Principle, SDGs, Statelessness
Criminal Justice Responses to Trafficking in Persons
Authors: Huong Ngo Thi Minh , Vu Giao Cong 
Published: July 2023

Human trafficking is a domestic and transnational crime that poses complex law enforcement challenges to all nations. Vietnam is particularly affected due to rapid growth in labour migration and international tourism. The presumption of law makers is that by improving the criminal justice response to trafficking in persons (TIP), its incidence within the country and beyond its borders will decrease. Inherent in this premise is the assumption that strong legal sanctions deter would-be traffickers. This paper describes Vietnam’s criminal justice responses to human trafficking with reference to the legal framework and institutions. Barriers and challenges in implementing the ASEAN Convention on Trafficking in Persons (ACTIP), and the underlying reasons why the current response is inadequate in addressing TIP are identified with a focus on issues associated with victims and trials. The paper argues that Vietnam needs to increase efforts to meet its obligations and standards as set out in the United Nation’s Recommended Principles and Guideline on Human Rights and Human Trafficking and ACTIP. In particular, prosecution of traffickers and the protection of victims need to be prioritised.

Keywords: Human Trafficking, Human Rights, Labor Migration, Criminal Justice, Vietnam
Study on the Synthesis and Properties of a New Salt-Resistant Drag Reducer
Authors: Ying Xiong , Lang Zhou , Pengfei Chen 
Published: July 2023

Summary
To solve the problem of poor salt resistance of conventional drag reducers, a hydrophobic associative polymer drag reducer was prepared by inverse emulsion polymerization with acrylamide (AM), methacrylic acid (MAA), 2-acrylamide-2-methylpropane sulfonic acid (AMPS), and hexadecyl dimethyl allyl ammonium chloride (C16DMAAC) as the main monomers. The synthetic product was confirmed as the target product by infrared (IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The viscosity-average molecular weight of the prepared drag reducer is 1100×104 g/mol. The pipeline friction results show that the drag reducer has good friction reduction and salt resistance. When the concentration in clean water is 0.06%, the maximum friction reduction rate is 71.1%. When the salinity is 5×104 mg/L, the calcium ion concentration is 2000 mg/L, and the suspended solid content is 500 mg/L, the maximum friction reduction rate is 68.9% when the concentration of the drag reducer is 0.06%. Salt water will not significantly lower the friction reduction rate. If the concentration of the drag reducer is increased to 0.08%, the maximum drag reduction rate will reach 73.8%. The microrheological test results of the friction reducer solution show that, at 0.2% concentration, there is no network structure between friction reducer molecules, which is consistent with Newtonian fluids possessing a certain viscosity. The elasticity index (EI) of the drag reducer solution is basically unchanged over time, maintaining good friction reduction and sand-carrying performance during the shearing process of large displacement pumping.
Quercetin improves diabetic cardiomyopathy by inhibiting pyroptosis via the Nrf2 pathway
Authors: Wei Zhang , zhou jing , kang pinfang , shi chao , qian shaohuan 
Published: July 2023

Abstract
Introduction: The aim of the study was to investigate whether quercetin can promote the translocation of Nuclear factor erythroid-2 related factor 2 (Nrf2) into the nucleus to inhibit pyroptosis progression and improve diabetic cardiomyopathy.
Research design and methods:The protective effect of quercetin against diabetic cardiomyopathy was evaluated using a diabetic rat model by analyzing the expression of pyroptosis pathway proteins, myocardial cell apoptosis rate, degree of myocardial fibrosis, and serum inflammatory indexes in the hearts of rats in each group. The expression of Nrf2 in the nucleus of myocardial tissue and H9C2 cells were analyzed to clarify the role of quercetin in promoting the translocation of Nrf2 into the nucleus. In addition, the Nrf2 inhibitor ml385 was co-incubated with the myocardial tissue to confirm that quercetin inhibits diabetes-induced cardiomyocyte pyroptosis via the Nrf2 pathway.
Results: Quercetin promoted the translocation of Nrf2 into the nucleus in the cardiac cells of diabetic rats, increased the expression of antioxidant proteins HO-1, GCLC, and SOD, reduced the accumulation of ROS and the level of cell apoptosis in diabetic cardiomyocytes, and alleviated the cardiac fibrosis caused by diabetes. The therapeutic effects of quercetin were further validated in H9C2 cardiomyocytes. Additionally, ml385 prevented the beneficial effects of quercetin on diabetic cardiomyopathy, further indicating that the inhibition of pyroptosis by quercetin requires the participation of the Nrf2 pathway.
Conclusions: Quercetin promotes the translocation of Nrf2 into the nucleus, increases the expression of antioxidant factors in cells, and inhibits the progression of cell pyroptosis thereby alleviating diabetic cardiomyopathy.
Small networks of expressed genes in the whole blood and relationships to profiles in circulating metabolites provide insights in inter-individual variability of feed efficiency in growing pigs
Authors: Juigné Camille , Becker Emmanuelle , Gondret Florence 
Published: July 2023

Abstract
Background: Feed efficiency is a research priority to support a sustainable meat production. It is recognized as a complex trait that integrates multiple biological pathways orchestrated in and by various tissues. This study aims to determine networks between biological entities to explain inter-individual variation of feed efficiency in growing pigs.
Results: The feed conversion ratio (FCR), a measure of feed efficiency, and its two component traits, average daily gain and average daily feed intake, were obtained from 47 growing pigs from a divergent selection for residual feed intake and fed high-starch or high-fat high-fiber diets during 58 days. Datasets of transcriptomics (60 k porcine microarray) in the whole blood and metabolomics (1H-NMR analysis and target gas chromatography) in plasma were available for all pigs at the end of the trial. A weighted gene co-expression network was built from the transcriptomics dataset, resulting in 33 modules of co-expressed molecular probes. The eigengenes of eight of these modules were significantly (P ≤ 0.05) or tended to be (0.05 < P ≤ 0.10) correlated to FCR. Great homogeneity in the enriched biological pathways was observed in these modules, suggesting co-expressed and co-regulated constitutive genes. They were mainly enriched in genes participating to immune and defense-related processes. They were also generally associated with growth rate and percentage of lean mass. In the network, only one module composed of genes participating to the response to substances, was significantly associated with daily feed intake and body adiposity. The profiles in circulating metabolites and fatty acids of plasma were summarized by weighted linear combinations using a dimensionality reduction method. Close association was notably found between a module composed of co-expressed genes participating to T cell receptor signaling and cell development process in the whole blood and related to FCR, and the circulating concentrations of omega-3 fatty acids in plasma.
Conclusion: These systemic approaches have highlighted networks of entities driving key biological processes involved in the phenotypic difference in feed efficiency between animals. Connecting transcriptomics and metabolic levels together had some additional benefits.
Exploring persistent organic pollutants (POPs) in the Danube River: An analysis of Polybrominated diphenyl ethers (PBDEs) and Per- and Polyfluorinated Substances (PFAS) using NORMAN Database
Authors: Saxena Priyam , Sarkar Atanu , Hazarika Rashmi , Pattanaik Abhishek , Yadav Om Prakash , Achari Gopal 
Published: July 2023

Abstract
Polybrominated diphenyl ethers (PBDEs) and per- and polyfluoroalkyl substances (PFAS) are environmental contaminants that have been widely detected in various matrices, including air, water, sediment, and biota, across the globe, but their sources and fate remain poorly understood. This review aims to explore the occurrence of PBDEs and PFAS in the Danube River. The study employs the NORMAN database repository as a source of data pertaining to persistent organic pollutants (POPs). This study compares and evaluates the occurrence patterns of PBDEs and PFAS in various countries along the Danube River basin. The spatial results demonstrate a decreasing trend for PBDEs in surface water and biota, while a significant increase for PFAS is observed. The distributions of PBDE congeners in biota samples mirrored the compositional profiles in the water, which were dominated by BDE-47 and/or BDE-99, while BDE-209 predominated in sediments. In regards to PFAS, PFOA and PFOS are prevalent in surface water. In conclusion, the occurrence of PBDEs and PFAS in Europe is of significant concern, and regulatory policies have been implemented to control their use and release into the environment. The results of this study can be used to assess the health and environmental risks posed by POPs in the Black Sea and can aid in the formulation of future public health policies.
Metformin's Impact on Follistatin and Oxyntomodulin in PCOS, and Comorbidities: Secondary Analysis of a Double-Blind RCT
Authors: Damasceno Rachel , Oliveira Flávia , Cândido Ana Lúcia , Gomes Karina , Bizzi Mariana , Azevedo Rosana , Comim Fábio , Reis Fernando , Rocha Ana Luiza 
Published: July 2023

Abstract
Background: Abnormal secretion of incretins, particularly Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and oxyntomodulin (OXM), have been observed in individuals with Type 2 diabetes mellitus and PCOS. OXM plays a crucial role in metabolism, including reducing food intake and improving insulin secretion to decrease liver fat accumulation. Metformin, an insulin-sensitizing hypoglycemic drug, is widely used in the PCOS treatment. However, the impact of metformin on circulating OXM levels remais unknown, and this study aims to investigate it. Design: This study presents a secondary analysis of a randomized double-blind clinical trial. Methods: Forty-five patients with PCOS were enrolled and randomly divided into two groups: one received metformin (n=21), and other received placebo (n=24). The study aimed to evaluate the levels of follistatin and oxyntomodulin before and after metformin tretament (1500mg/day). Blood levels of oxyntomodulin and follistatin were assessed by ELISA tests. Results: At the end of the study, 20 patients were evaluated, including 5 (25%) from the metformin group and 15 (75%) from the placebo group. There was no significant difference in the variation of follistatin and oxyntomodulin levels between the metformin and placebo groups. However, a significant difference in follistatin levels was observed among participants with hyperandrogenic and non-hyperandrogenic phenotypes. There was no significant difference in oxyntomodulin levels in different phenotypes. Conclusion: Treatment with metformin for 60 days did not have a impact on follistatin and oxyntomodulin levels. However, a significant difference was found in follistatin values between participants with hyperandrogenic and non-hyperandrogenic phenotypes.
Trial registration: Brazilian Registration Platform for Clinical Studies - REBEC -ID RBR-47tvky – Date of fist registration: 04/07/2017/ Brazilian Health Ministry- ID 17127713.2.0000.5149.
Cobenefit Effect Between Pollution Reduction and Carbon Emission Mitigation: Evidence from Cities in the Middle Reaches of the China Yangtze River
Authors: Zhou Zhiyi , Zhu Yongguang , Gong Yuna , Xu Deyi 
Published: July 2023

Abstract
This paper is based on the actual problems of the coordinated treatment of pollution reduction and carbon emission mitigation in the urban agglomeration in the middle reaches of the China Yangtze River. It makes two main contributions. First, on the basis of cross-impact analysis, the cobenefit variable of pollution reduction and carbon emission mitigation is added to measure the cobenefit effect more intuitively and accurately. Second, on the basis of adding cobenefit variables and taking into account regional and dynamic characteristics, variable coefficient regression is conducted on the cobenefit variables. It is found that the level of the cobenefit effect of pollution reduction and carbon emission mitigation of the urban agglomeration in the middle reaches of the Yangtze River in different regions is not only spatially heterogeneous but also heterogeneous between different types of cobenefit effects. The interregional collaborative level of pollution reduction in the urban agglomeration is better than that of carbon emission mitigation. Then, compared with carbon emission mitigation policy investment, carbon emission mitigation technology investment and pollution reduction investment have a higher cobenefit effect. At the same time, carbon emission mitigation investment has higher comprehensive benefits than pollution reduction investment.
Effects of microbes in pig farms on occupational exposed persons and the environment
Authors: Han Jinyi , Li Mengyu , Li Xin , Liu Chuang , Li Xiu-Ling , Wang Kejun , Qiao Ruimin , Yang Feng , Han Xuelei , Li Xin-Jian 
Published: July 2023

Abstract
Pig farming has an effect on farmers and the farm environment. Pig gut microbes play an important role in this effect. However, which microbial composition is more likely to be affected remains unknown. Primarily, we collected 136 samples in pig farm A, including 70 pig fecal, 18 farmers, 4 individuals without contact with any type of farm animal (“non-exposed” persons) fecal, and 44 environmental dust samples (dust from inside and outside pig houses and the farm). Another 43 samples were collected from pig farm B, including 10 pig fecal, 24 environment samples, and 9 humans fecal. Whereafter, 16S rRNA sequencing and taxonomic composition analysis were performed. Result showed that pig farmers significantly upregulated 13 genera compared with non-exposed persons, and 76 genera were significantly upregulated inside the pig house than outside the pig house. Comparing non-exposed persons who were farther away from the pig farm, the results showed that the relative abundance of three microbes, including Turicibacter, Terrisporobacter, and Clostridium_sensu_stricto_1, increased between the farmers and environment inside and outside the pig farm, and significant differences were observed (P < 0.05). Moreover, the abundance increased with the exposure time of farmer animals and spatial location to pigs. The greater the distance from the farm, the less effective the three microbes were. Although the distance is about 550 km, the analysis results of pig farm A and pig farm B confirm each other. This study shows that the three microbes where pig farmers co-occurring with the environment come from pig farms, which provides new ideas for blocking the transmission of microbial aerosols in pig farms and reducing pollution.
Moderately delayed maturation of composting promotes the reduction of guild-plant pathogenic fungi within vegetable waste
Authors: Lv Zijian , Tao Chengyuan , Zhang Jiawei , Shen Zongzhuan , Wang Dongsheng , Wang Bei , Liu Hongjun , Li Rong 
Published: July 2023

Abstract
The relationships among the relative abundance of guild-plant pathogenic fungi, compost maturation index and microbial community variation during vegetable waste composting, which are influenced by the C/N ratio, remain poorly understood. To address this, fungal communities were analyzed in composting treatments with C/N ratios of approximately 15 (CN15) and 25 (CN25), using vegetable waste as the primary raw material. The CN15 treatment showed greater microbial community variation and a better overall compost maturation index value than the CN25 treatment. However, the CN25 treatment had a greater decline in plant-pathogenic fungi than the CN15 treatment. Notably, the relative abundance of guild-plant pathogenic fungi was significantly negatively related to the compost maturity index in the CN25 treatment, while no significant relationship was observed in the CN15 treatment. This study suggests that the moderately delayed maturation of composting is beneficial for reducing guild-plant pathogenic fungi in vegetable waste.
A nonlinear quantum scheme of a single mode optical field and a four-level atom under energy dissipation effect
Authors: Raffah Bahaaudin , Berrada Kamal , Khalil Eied M. , Abdel-khalek Sayed 
Published: July 2023

Abstract
In this interferometry the geometrical phase, von-Neumann entropy, and non-classical features of a field interacting with a four-level moving atom in the presence of a Kerr medium were investigated. We highlight the influence of intensity-dependent coupling and energy dissipation to examine the temporal behavior of the geometrical phase, the statistical properties of the field as well as the von-Neumann entropy. The results show that the evolution of system dynamics, atomic von-Neumann entropy, and geometrical phase are strongly influenced by the Kerr medium, field mode structure, and atomic motion. Using empirically available parameters, we test this result, and many new items are discovered.