bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laminitis equina in vitro inducida por veneno entero y Fosfolipasa A2 de serpiente Bothrops alternatus de Argentina
Authors: Teibler G. P. , Maruñak L. S. , Bogado E. F. , Pollitt C. 
Published: December 2022

Bothrops alternatus (yarará grande, víbora de la cruz) es una serpiente perteneciente a la familia Viperidae, y se encuentra ampliamente distribuida en Argentina. En el nordeste de nuestro país, esta serpiente ocasiona el mayor número de accidentes. Existen reportes de envenenamiento en equinos, siendo sus signos y síntomas más importantes: inflamación y hemorragia, dermo y mionecrosis en el área de inoculación del veneno. Por otro lado, la acción sistémica consiste en incoagulabilidad sanguínea, hemorragia y lesiones de órganos que pueden comprometer la salud del animal. Una secuela, debida a la intoxicación por esta serpiente, es la laminitis, que afecta la capacidad de trabajo del equino, independientemente del sitio de inoculación del veneno, debido a la acción sistémica del mismo. Esta patología produce dolor, claudicación, que luego puede progresar con deformación del casco. Se efectuó un estudio in vitro, tomando como modelo experimental muestras (explantes) de pie equino. Estas fueron incubadas con veneno entero y con Fosfolipasa A2 (PLA2) del mismo veneno con el objeto de reproducir laminitis a los efectos de corroborar datos clínicos reportados en accidentes por yarará como así también proponer una metodología de estudio de laminitis en explantes de pie equino. La laminitis inducida por el veneno entero se caracterizó por la separación de la unión dermo–epidérmica, desprendimiento de membrana basal y citotoxicidad y consecuentemente desprendimiento de unión dermo–epidérmica, permaneciendo las células basales epidérmicas con alteraciones en forma y tamaño de los núcleos, entre otras anormalidades. En contraste, las muestras incubadas con PLA2, las células basales epidérmicas mostraron anomalías citoplasmáticas y nucleares, pero con separación leve de la unión dermoepidérmica y presente solo en algunas áreas de las LES.
Hepatozoonosis en caninos domésticos del Gran Buenos Aires
Authors: Martin P. L. , Pintos M. E. , Aquino S. , Vidal D. A. , Arauz M. S. 
Published: December 2022

La hepatozoonosis canina (HC) es una enfermedad transmitida por la ingestión de garrapatas infectadas con Hepatozoon canis que puede causar signos clínicos graves dependiendo de la inmunidad del hospedador. El objetivo de este trabajo fue detectar la presencia de H. canis en muestras de caninos sin signología provenientes del Gran Buenos Aires a través de la observación microscópica en extendidos de sangre periférica y capa flogística. Posteriormente, se determinó la casuística de la HC en los diferentes barrios, la asociación entre las variables raza, sexo, edad y la presencia de garrapatas con el diagnóstico hematológico positivo de HC y la asociación entre las alteraciones del hemograma y la presencia de HC. De las 207 muestras 10 (4,83%) fueron positivas mediante la observación en frotis de sangre periférica y 15 (7,24%) en frotis de sangre periférica y extendidos de la capa flogística. Con respecto a las variables evaluadas, la HC fue más frecuente en adultos, hembras, de raza mestiza y con presencia de garrapatas, no obstante las diferencias no fueron significativas. El mayor porcentaje de muestras positivas se observó en aquellos pacientes provenientes de los barrios de Solano y Quilmes. En relación a las alteraciones hematológicas en el grupo de muestras positivas a HC se observó anemia (20%), leucocitosis (40%), linfocitosis (26,6%) y eosinofilia (80%) en un mayor porcentaje con respecto al grupo de muestras negativas, no obstante las diferencias entre ambos grupos no fueron significativas (p>0,05). Este estudio corrobora la endemicidad de la HC en el Gran Buenos Aires y demuestra que la prevalencia varía con la procedencia de las muestras y del momento en que se realiza el estudio. Asimismo, refleja la utilidad de la concentración leucocitaria para aumentar las probabilidades de observación positiva de gamontes cuando no se disponga de métodos moleculares.
Evaluación preliminar del poder antigénico in vivo de una nueva formulación para la inmunoprofilaxis de la babesiosis bovina
Authors: Álvarez F. R. , Peichoto M. E. , Palma S. , Maletto B. , Lozina L. 
Published: December 2022

La babesiosis bovina es una enfermedad hemoparasitaria causada por protozoarios del género Babesia, siendo los de mayor importancia Babesia bovis y B. bigemina, ambos transmitidos por la garrapata común del bovino, Rhipicephalus microplus. Junto con la anaplasmosis, forman el complejo tristeza bovina, uno de los principales factores limitantes para el desarrollo productivo en zonas tropicales y subtropicales del mundo. Actualmente, para la profilaxis de la babesiosis bovina en Argentina solo se dispone de vacunas vivas en las presentaciones, fresca y ultra congelada. En el presente trabajo, se evaluó la inmunogenicidad de eritrocitos parasitados con Babesia sp y deshidratados, incorporados a un nuevo adyuvante, formulado para uso en humanos, como una nueva alternativa inmuno profiláctica. Con tal fin, eritrocitos parasitados obtenidos a partir de cultivos in vitro, fueron deshidratados por técnicas de secado por aspersión y ensamblados con un adyuvante. Se utilizaron 12 terneros negativos a hemoparásitos que fueron distribuidos en 4 grupos de 3 animales cada uno. Grupo Control: sin inocular; Grupo Tratado 1: inoculado con adyuvante; Grupo Tratado 2: adyuvante + eritrocitos parasitados con B. bovis y Grupo Tratado 3: adyuvante + eritrocitos parasitados con B. bigemina. Se realizaron dos inoculaciones subcutáneas, los días 0 y 15. Durante 60 días, se realizó el control de temperatura rectal, hematocrito y parasitemia, así como el muestreo para serología a los 30 y 60 días post-inoculación. Los animales se mantuvieron negativos durante todo el ensayo, excepto al día 60, donde el 33% del Grupo Tratado 3 presentó titulación de anticuerpos contra el agente inoculado, B. bigemina. Si bien el porcentaje de respuesta es bajo, el hecho de no contar a nivel mundial con una vacuna muerta eficaz para la profilaxis de esta enfermedad, nos alienta a continuar ajustando la dosis inoculante.
Peranan Kreativitas Guru terhadap Motivasi Belajar Peserta Didik Sekolah Dasar
Authors: Jusar Ira Rahmayuni , Mudjiran Mudjiran 
Published: December 2022

This study aims to determine the role of an elementary school teacher on students' learning motivation. One of the elements that influence the success of a student is motivation. If students have the drive to learn, then they will achieve the desired learning outcomes. In an effort to produce quality learning and education, teachers must be creative. To encourage motivation to acquire the principles of the creed, the teacher must be able not only to understand the teaching material but also various learning methods and designs. The findings show that teachers can increase students' motivation in learning in various ways, including by providing teaching materials, using various teaching techniques, managing classes, and utilizing learning media. High learning motivation will lead to the best results, the task of a teacher is to foster student motivation. The research methodology in research is a literature review (library research) available in online or offline libraries. The main component in learning, motivation can support and encourage learning. According to literature findings, students with high levels of motivation are more likely to try hard, dress impeccably, and not want to give up. They are also more likely to engage actively in reading to improve learning outcomes and solve problems. On the other hand, people who are unmotivated, appear disinterested, get discouraged easily, and don't pay attention to what they are learning will have difficulty in school.
EMOTION DYSREGULATION AFFECTS FUNCTIONALITY IN MAJOR DEPRESSIVE DISORDER
Authors: KELEŞ ALTUN İlkay 
Published: December 2022

Purpose: Mood disorders are recurrent chronic mental illnesses known to affect functionality. In this study, it was aimed to compare coping strategies and emotion regulation difficulties in depression and bipolar disorder and observe the effects of coping strategies and emotion regulation on functionality.
Methods: 31 patients with bipolar disorder (BD), 29 with major depressive disorder (MDD), and 27 healthy controls (HC) were included in the study. Participants completed the Coping Strategies Inventory (COPE), Bipolar Disorder Functioning Questionnaire (BDFQ), Difficulties in Emotion Regulation Scale (DERS), Hamilton Depression Scale (HAM-D), and Young Mania Rating Scale (YMRS).
Results: In the BD group, a positive significant correlation was found between COPE-M and DERS scores, and a negative significant correlation was found between COPE-M and BDFQ. In the MDD group, a positive significant correlation was found between COPE-A and BDFQ scores, and a negative significant correlation was found between DERS and BDFQ. BDFQ was statistically significantly predicted positively by COPE-A and negatively by DERS.
Conclusion: It was thought that emotion dysregulation may predispose to depressive symptomatology and negatively affect clinical course and functionality. Addressing emotion regulation difficulties and increasing the use of adaptive coping strategies in therapeutic interventions contribute to the improvement of functionality as well as clinical improvement.
ВЗАЄМОДІЯ ПОВЕРХНЕВОЇ ПООДИНОКОЇ ХВИЛІ ІЗ ЗАНУРЕНИМ ТА НАПІВЗАНУРЕНИМ ХВИЛЕГАСНИКАМИ
Authors: Горбань І. М. , Корольова А. С. , Лебідь О. Г. 
Published: December 2022

Експериментально досліджена взаємодія поверхневої солітонної хвилі з напівзануреною висячою стінкою та підводним бар’єром. В експериментах змінювалися амплітуда падаючої хвилі, осадка напівзануреної стінки та висота підводного бар’єру. Ці дослідження були спрямовані на визначення найбільш ефективних конфігурацій берегозахисних споруд з точки зору коефіцієнтів відбиття та проходження хвилі. Отримано, що при набіганні солітонної хвилі на навісну стінку відбитий солітон утворюється з накату падаючої хвилі на споруду, а прохідний солітон формується після проходження рідини крізь зазор між дном і низом стінки. Характер взаємодії солітонної хвилі із зануреним бар'єром залежить від відношення амплітуди падаючої хвилі до товщини стовпа води над перешкодою. Коли значення цього параметру менше за критичне, що становить приблизно 1, падаюча хвиля м’яко поділяється на відбитий і прохідний солітони. Інакше, переміщення хвилі супроводжується інтенсивними хаотичними коливаннями вільної поверхні в околі споруди. Отримані з експериментів оцінки коефіцієнтів відбиття та проходження хвилі показують, що тонкі вертикальні бар’єри є достатньо ефективними в якості хвилегасників, а цільовий захист берегу може бути досягнутий за рахунок найкращого вибору осадки непроникної частини навісної стінки або висоти зануреної перешкоди. Виявлено, що навісна стінка, яка виступає за поверхню води, більш ефективно гасить енергію солітонних хвиль, ніж встановлений на дно підводний бар’єр. Вона може розсіювати до 60% енергії падаючої хвилі, тоді як повністю занурена споруда – до 20%.
Formirovanie uchetno-analiticheskoi informatsii o raschetakh s postavshchikami i pokupateliami
Authors: Soldatova Liubov Ivanovna 
Published: December 2022

Currently, in the conditions of market relations, organizations have significantly increased the number of counterparties – product suppliers and buyers, that is, debtors and creditors, due to a number of objective and subjective factors, the procedure for accounting and reporting receivables and payables has become more complicated.
In order to properly build relationships with customers, it is necessary to constantly monitor the current state of mutual settlements and monitor trends in their changes in the medium and long term. At the same time, control should be differentiated in relation to different groups of customers, distribution channels, regions and forms of contractual relations.
Accounts receivable and accounts payable are a natural phenomenon for the system of settlements between enterprises existing in Russia.
In the structure of receivables and payables, the largest share (up to 90%) is occupied by obligations to suppliers and claims to buyers, therefore, these indicators directly affect the solvency and financial stability of organizations.
The problems of reliability and timeliness of accounting, reporting and analytical information on settlement transactions with partners in commodity transactions, which affect the effectiveness of tactical and strategic management, are becoming especially relevant.
PENELUSURAN MORTALITY RISK FACTORS DAN DIGITAL INNOVATION DALAM MEMBANGUN KETAHANAN USAHA MIKRO, KECIL, DAN MENENGAH (UMKM) DI KOTA MAKASSAR
Authors: Hardi Rudi , Khaerah Nur , Putra Muhammad Amril Pratama , Nurjannah Nurjannah , Ismawati Ismawati , Sari Mayang , Fajar Muhammad 
Published: December 2022

Permasalahan yang dihadapi UMKM yaitu kualitas SDM, kepemilikan, pembiayaan, pemasaran, kesulitan bersaing dengan perusahaan yang besar.Selain itu, masih berorientasi jangka pendek dan rendahnya konsep inovasi yang sistematis. Untuk dapat tetap hidup, UMKM perlu menumbuhkan iklim inovasi serta penguasaan teknologi, khususnya yang terkait dengan transformasi digital. Tujuan penelitian ini adalah menelusuri Faktor Risiko Kematian dan Inovasi Digital pada UMKM untuk menemukan strategi membangun ketahanan UMKM dari keterpurukan lebih jauh. Terutama menelusuri dan mengidentifikasi Mortality Risk Factors sebagai indikator kekuatan bertahan UMKM dari kematian. Serta, menelusuri inovasi digital sebagai syarat penting UMKM untuk dapat beradaftasi pada perkembangan digitalisasi usaha. Metode Penelitian ini menggunakan kombinasi metodologi penelitian yaitu metode kuantitatif, metode kualitatif, serta historical analysis. Metode kualitatif menggunakan pendekatan observer-participant. Metode kuantitatif yaitu melalui cross-sectional dilakukan dengan convenience sampling, atau availability sampling. Historical analysis digunakan untuk dokumentasi situasi UMKM masa lalu. Hasil Penelitian menunjukkan bahawa permasalahan yang dihadapi UMKM di kota Makassar yang menjadi faktor yang dapat mendorong risiko kematian (risiko kebangkrutan/”gulung tikar”) yaitu kualitas SDM, kepemilikan, pembiayaan, pemasaran, kesulitan bersaing dengan perusahaan yang besar serta masih berorientasi jangka pendek dan rendahnya penggunaan inovasi yang sistematis. Kemudian faktor yang paling dominan penyebab risiko kematian UMKM adalah: manajemen, wirausaha, dan inovasi. Dalam 'wirausaha' perlu meningkatkan keterampilan dan kompetensi yang akan mencerminkan produktivitas organisasi. Dalam manajemen, wirausahawan harus mengetahui semua alat yang diperlukan dan tersedia untuk kinerja bisnis yang baik dan meminimalkan kegagalan sambil meningkatkan manajemen. Melalui inovasi, produk dan layanan diciptakan untuk melayani konsumen, dan proses organisasi dirampingkan untuk meningkatkan produktivitas bisnis.
VÍNCULO MÃE-FILHO E OPORTUNIDADES PARA O DESENVOLVIMENTO MOTOR DE LACTENTES EXPOSTOS E NÃO EXPOSTOS AO HIV
Authors: Ruivo Camila Ortega , Pádua Raissa Felipe , Sá Cristina Dos Santos Cardoso de 
Published: December 2022

Objetivos: Caracterizar e avaliar o vínculo mãe-filho, as oportunidades domiciliares e o desenvolvimento motor de lactentes expostos e não expostos ao HIV entre 4 a 12 meses de idade. Métodos: Estudo transversal com 48 lactentes e suas mães, sendo 21 expostos ao HIV e 27 não expostos. As mães responderam ao Protocolo de Avaliação do Vínculo Mãe-Filho, o questionário Affordances no Ambiente Domiciliar, o desenvolvimento motor foi avaliado pela Alberta Infant Motor Scale (AIMS). Aplicou-se a correlação de Pearson, e nível de significância p-valor <0,05. Resultados: A correlação entre vínculo mãe-filho e grupo é positiva (r=0,330; p=0,022). Os lactentes expostos ao HIV apresentaram menor vínculo mãe-filho (p=0,006). Conclusão: Houve relação entre menor vínculo mãe-filho entre os lactentes expostos ao HIV, mas não houve diferenças em relação ao desenvolvimento motor e as oportunidades domiciliares.
Acute worsening of CADASIL in a patient with COVID-19 infection: illustrative case
Authors: Rosenblum Jared S. , Tunacao Jessa M. , Nazari Matthew A. , Ronk Halle , Dang Danielle D. , Downing Chad , Zhuang Zhengping , Heiss John D. , Smirniotopoulos James G. , Bluestone Avraham , Badia James , White Joseph 
Published: December 2022

BACKGROUND
Reports of cerebrovascular ischemia and stroke occurring as predominant neurological sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which causes coronavirus disease 2019 (COVID-19), are increasingly evident within the literature. While various pathophysiological mechanisms have been postulated, including hypercoagulability, endothelial invasion, and systemic inflammation, discrete mechanisms for viral neurotropism remain unclear and controversial.

OBSERVATIONS
The authors present a unique case study of a 64-year-old male with acute COVID-19 infection and acute worsening of previously stable cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a rare heritable arteriopathy due to mutation in the Notch3 gene, which is critical for vascular development and tone. Delayed cranial neuropathies, brainstem fluid-attenuated inversion recovery signal, and enhancement of olfactory and vagus nerves on magnetic resonance neurography in this patient further support viral neurotropism via cranial nerves in addition to cerebral vasculature.

LESSONS
To the authors’ knowledge, this is the first case in the literature that not only demonstrates the consequences of COVID-19 infection in a patient with altered cerebrovascular autoregulation such as CADASIL but also highlights the tropism of SARS-CoV-2 for (1) cranial nerves as a mode of entry to the central nervous system and (2) vessels as a cause of cerebrovascular ischemia.
THE INFLUENCE OF NASAL BREATHING DISORDERS ON THE ORAL FLUID PARAMETERS IN PRESCHOOL CHILDREN
Authors: Ulasevych L.P. 
Published: December 2022

Dental caries is the most common dental disease in preschool children. Negative changes in the quantitative and qualitative parameters of oral fluid create optimal conditions for the development of cariogenic situation. One of the most important factors of oral cavity homeostasis changes in children of 3-6 years old is a persistent disorder in nasal breathing.
The aim of the research is to determine the rate of saliva secretion and mixed saliva viscosity for their possible implementation as the biomarkers of risk of tooth caries appearence and justification of therapeutic and preventive measures prescription for elimination of the cariogenic situation in preschool children with persistent nasal breathing disorders. The rate of salivation and the viscosity of oral fluid were determined according to the method of Redynova T. L., Pozdeev A. R. (1994).
The analysis of the obtained data on the rate of salivation of the examined children of the main and control groups revealed that the average value is within the normal range or at the lower margin of the parameter. A 1.5-fold decrease in the rate of salivation was found in children with persistent nasal breathing disorders compared to practically healthy children (р≤0.05). A more pronounced parameter decrease is observed in case of deciduous teeth presense. The average value of the viscosity of oral fluid is 2 times higher in children with persistent nasal breathing disorders than in the control group (р≤0.05). Higher viscosity of mixed saliva was found in children with caries than in children without it, but in the main group the numerical values were significantly higher (р≤0.05).
The obtained data confirms the possibility of implementation of the determination of saliva secretion and viscosity rate as biomarkers of the tooth caries development in preschool children and provide an opportunity to control the application of therapeutic and preventive measures, considering the presence of nasal breathing disorders.
Environmental Transparency Rating of Oil and Gas Companies Operating in the Arctic: 2014—2021
Authors: Trubitsina O. P. , Bashkin V. N. 
Published: December 2022

The article focuses on identifying the dynamics of indicators and criteria for the rating of environmental transparency of oil and gas industry facilities in the Russian Arctic for 2014—2021. The authors managed to identify the general and differentiated dynamics of greening of the Arctic oil and gas sector enterprise in three sections: managerial, operational and informational. The leaders of the environmental rating have been identified — Sakhalin Energy (Sakhalin-2), LUKOIL, Zarubezhneft.
Socio-Economic Risks and Threats in the Economic Security System of the Region
Authors: Ryazanova O. A. , Timin A. N. 
Published: December 2022

The article deals with the issues of socio-economic risks and their definition through the criteria of economic security of the region. The criteria for assessing the social security of the region are highlighted; the methodology for processing primary data and their translation into a point assessment is developed and justified.The purpose of this article is to review and assess socio-economic risks and threats in the economic security system of the region on the example of the Kirov region.The objectives of the work are to review the main socio-economic risks and threats of the Kirov region, to study the methodological aspects of assessing socio-economic risks and threats in the economic security system of the region, to analyze and evaluate socio-economic indicators in the economic security system of the Kirov region.The basis of the developed system is the use of statistical data and grouping of indicators based on causal relationships between indicators. Based on the results of the study, an analysis of the economic security of the Kirov region by social groups of factors based on the presented criteria was carried out.
Bone height and width evaluation before dental implant placement on panoramic radiographs: a scoping review
Authors: Asmarani Shely Levita , Azhari Azhari , Pramanik Farina 
Published: December 2022

Objectives: The aim of this study is to evaluate the bone height and its width on panoramic radiography prior to dental implant placement.
Review: This study was carried out using scoping review methods. The referenced articles were published between 2010-2021 in English or Indonesian. The search was performed using PubMed and PMC database with keywords “(((Evaluation) AND (Presurgical)) AND (Dental Implant)) AND (Radiograph)) AND (Panoramic)” and Science Direct with keywords "presurgical evaluation dental implant in panoramic radiograph". Preferred Reporting Items for Systematic Review and Meta-analysis Scoping Review (PRISMA-Scr) was utilized to perform the article finding process. It is found that the height of alveolar bone after being assessed by panoramic radiograph is between 7.95-23.42 mm while the alveolar bone width is between 7.04-10.41 mm.
Conclusion: Panoramic radiograph can be performed to evaluate bone height and width before the dental implant placement procedure.