bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scale for the assessment and rating of ataxia (SARA): Übersetzung und kulturelle Anpassung an den deutschsprachigen Raum
Authors: Silberbauer Julia , Schidl Sonja , Diermayr Gudrun , Schmitz-Hübsch Tanja , Greisberger Andrea 
Published: April 2023

Zusammenfassung
Hintergrund/Ziel
Die Scale for the Assessment and Rating of Ataxia (SARA) ist ein praxistaugliches Assessment für die Einschätzung des Schweregrades einer Ataxie und für die Evaluierung von Therapiemaßnahmen. Um im deutschsprachigen Raum über eine entsprechend internationalen Vorgaben übersetzte Version zu verfügen, war das Ziel dieser Arbeit, die SARA ins Deutsche zu übersetzen und für den deutschsprachigen Raum kulturell anzupassen.

Methode
Der Übersetzungsprozess beinhaltete 6 Schritte. Dabei wurde die Verständlichkeit der Übersetzung in Interviews mit den späteren Nutzer*innen überprüft.

Ergebnisse
Neun Physiotherapeut*innen und sechs Ärzt*innen mit unterschiedlichen Arbeitsumgebungen wurden interviewt. Sieben Personen waren in Deutschland und je vier in Österreich bzw. der Schweiz tätig. Die Interviews führten zu einer Präzisierung der übersetzten Version. Im länderspezifischen Vergleich wurden keine Auffälligkeiten der Verständlichkeit festgestellt.

Schlussfolgerung
Mit dieser Arbeit ist eine von der Mitautorin der Originalpublikation autorisierte deutsche Version der SARA verfügbar. Die Ergebnisse liefern außerdem methodische Erkenntnisse zum Übersetzungsprozess von beobachtungsbasierten standardisierten Assessments.
Human Cancer Cell Radiation Response Investigated through Topological Analysis of 2D Cell Networks
Authors: Tirinato Luca , Onesto Valentina , Garcia-Calderon Daniel , Pagliari Francesca , Spadea Maria-Francesca , Seco Joao , Gentile Francesco 
Published: April 2023

AbstractClonogenic assays are routinely used to evaluate the response of cancer cells to external radiation fields, assess their radioresistance and radiosensitivity, estimate the performance of radiotherapy. However, classic clonogenic tests focus on the number of colonies forming on a substrate upon exposure to ionizing radiation, and disregard other important characteristics of cells such their ability to generate structures with a certain shape. The radioresistance and radiosensitivity of cancer cells may depend less on the number of cells in a colony and more on the way cells interact to form complex networks. In this study, we have examined whether the topology of 2D cancer-cell graphs is influenced by ionizing radiation. We subjected different cancer cell lines, i.e. H4 epithelial neuroglioma cells, H460 lung cancer cells, PC3 bone metastasis of grade IV of prostate cancer and T24 urinary bladder cancer cells, cultured on planar surfaces, to increasing photon radiation levels up to 6 Gy. Fluorescence images of samples were then processed to determine the topological parameters of the cell-graphs developing over time. We found that the larger the dose, the less uniform the distribution of cells on the substrate—evidenced by high values of small-world coefficient (cc), high values of clustering coefficient (cc), and small values of characteristic path length (cpl). For all considered cell lines, $$sw>1$$

s
w
>
1

for doses higher or equal to 4 Gy, while the sensitivity to the dose varied for different cell lines: T24 cells seem more distinctly affected by the radiation, followed by the H4, H460 and PC3 cells. Results of the work reinforce the view that the characteristics of cancer cells and their response to radiotherapy can be determined by examining their collective behavior—encoded in a few topological parameters—as an alternative to classical clonogenic assays.
The Relationship Between Forgiveness and Health Outcomes Among People Living with HIV: A Cross-Sectional Study in France
Authors: Toussaint Loren L. , Skalski-Bednarz Sebastian Binyamin , Lanoix Jean-Philippe , Konaszewski Karol , Surzykiewicz Janusz 
Published: April 2023

AbstractResearch to date has shown that HIV infection is a highly stressful experience for individuals, and one of the key adaptive resources after such painful experiences may be forgiveness. The aim of the present study was to examine the associations between dispositional forgiveness (assessed using Mullet’s Forgivingness Questionnaire and Toussaint’s Forgiveness Scale), perceived stress (single-item measure of stress symptoms), health perception (EuroQol visual analogue version of the scale) and life satisfaction (Satisfaction With Life Scale) in people living with HIV (PLWH) in France. Paper surveys were completed by 222 PLWH aged 18–78 (57% male). Multiple regression analysis revealed that sensitivity to circumstances, unconditional forgiveness, self-forgiveness, and forgiveness of others were significant predictors of health and happiness. Mediation analysis showed that these relationships are completely mediated by perceived stress. The present findings suggest that forgiveness and perceived stress may be important variables for healing in PLWH. Interventions designed to improve forgiveness and self-forgiveness may result in improved health and life satisfaction in PLWH.
Seismic vibration mitigation of steel storage tanks by metafoundations endowed with linear and bistable columns
Authors: Guner Tugberk , Bursi Oreste S. , Broccardo Marco 
Published: April 2023

AbstractThis paper presents the seismic mitigation of typical storage tanks where extreme loading conditions are considered by safe shutdown earthquakes. To reproduce the main dynamic properties of the superstructure, a standard structural model was considered, where both the presence of the impulsive mode and of the convective mode were considered. Thus, to protect the tank from strong earthquakes, finite locally resonant multiple-degrees-of-freedom (MDoFs) metafoundations were designed and developed; and resonator parameters together with bistable columns were optimized by means of an improved time domain multiobjective optimization procedure. Also, the stochastic nature of the seismic input was taken into account. Therefore, it is proposed: (i) a linear metafoundation endowed with one/two layers and multiple cells, linear springs, and linear viscous dampers; and (ii) a relevant foundation equipped with columns operating in an elastic buckled state. With this arrangement, additional flexibility and dissipation against horizontal seismic loadings are activated. It was shown in both cases, how each metafoundation can be successfully optimized via a sensitivity-based parameter technique. Thus, the performance of the optimized metafoundations was assessed by means of time history analyses; and results were compared with a storage tank endowed with both rigid foundation solutions. Finally, single cells were analysed in the frequency domain while finite lattices and periodic metafoundations in the linear and bistable regime were characterized by means of dispersion relationships.
Two Azores shipwrecks and insect biological invasions during the Age of Discovery
Authors: Panagiotakopulu Eva , Garcia Ana Catarina 
Published: April 2023

AbstractInsect faunas from a Spanish and a Dutch shipwreck, Angra D and Angra C, recovered from a bay on Terceira island, Angra do Heroísmo, in the Azores, and dated to c. 1650 CE, provide information about the onboard ecology of seventeenth century shipping vessels and the role of these ships and of contemporary maritime routes in biological invasions. In addition to evidence for foul conditions, there is evidence for similar insect faunas on both these ships. The assemblages include the earliest records of the now cosmopolitan synanthropic scuttle fly Dohrniphora cornuta (Bigot) which was probably introduced through trade from southeast Asia to Europe. The presence of the American cockroach, Periplaneta americana (L.) from Angra D, in the context of other sixteenth and seventeenth century records from shipwrecks, gives information about its spread to North America and Europe through transatlantic and transpacific trade, hitching a ride with traded commodities. The insect data point to the importance of introduced taxa on traded commodities and ballast, transported from port to port, and the role of ports of call like Angra in the Azores, as hot spots for biological invasions.
Novel insights on atomic synchronization for sort-based group-by on GPUs
Authors: Gurumurthy Bala , Broneske David , Schäler Martin , Pionteck Thilo , Saake Gunter 
Published: April 2023

AbstractUsing heterogeneous processing devices, like GPUs, to accelerate relational database operations is a well-known strategy. In this context, the operation is highly interesting for two reasons. Firstly, it incurs large processing costs. Secondly, its results (i.e., aggregates) are usually small, reducing data movement costs whose compensation is a major challenge for heterogeneous computing. Generally, for computation on GPUs, one relies either on sorting or hashing. Today, empirical results suggest that hash-based approaches are superior. However, by concept, hashing induces an unpredictable memory access pattern conflicting with the architecture of GPUs. This motivates studying why current sort-based approaches are generally inferior. Our results indicate that current sorting solutions cannot exploit the full parallel power of modern GPUs. Experimentally, we show that the issue arises from the need to synchronize parallel threads that access the shared memory location containing the aggregates via . Our quantification of the optimal performance motivates us to investigate how to minimize the overhead of atomics. This results in different variants using atomics, where the best variants almost mitigate the atomics overhead entirely. The results of a large-scale evaluation reveal that our approach achieves a 3x speed-up over existing sort-based approaches and up to 2x speed-up over hash-based approaches.
Efficacy of salvage therapies after failure of adjuvant anti-PD-1 monotherapy for melanoma in the Chinese population: a multi-institutional cohort study
Authors: Jia Dong-Dong , Xu Yu , Li Ting , Yang Ji-Long , Chen Yong , Li Tao 
Published: April 2023

SummaryThe majority of melanoma patients experience relapse during adjuvant therapy or after the end of therapy. Sixty-one patients from 3 melanoma centres who experienced recurrence and received adjuvant pembrolizumab for resected stage III/IV melanoma were enrolled. Disease characteristics, recurrence characteristics, subsequent management and outcomes were retrospectively analysed. Sixty-one patients were enrolled in this study. The median time to first relapse from the commencement of adjuvant pembrolizumab was 8 months (1–22 months). The first recurrences were locoregional alone in 25 patients (41%), distant alone in 29 (47.5%) and concurrent locoregional and distant relapse in 7 (11.5%). At the first recurrence, 4 patients (80%) who underwent resection alone experienced further relapse of disease. Three (60%) patients who were treated with adjuvant pembrolizumab following surgery, 2 (100%) patients who were treated with adjuvant chemotherapy, 2 (66.7%) patients who were treated with adjuvant chemotherapy and pembrolizumab combined and 3 (100%) patients who were treated with adjuvant radiotherapy and pembrolizumab combined had further recurrence. Of the three patients treated with adjuvant BRAF/MEKi following the first relapse, none had yet recurred. Of the 8 patients treated with pembrolizumab alone, only one patient (12.5%) who recurred after ceasing adjuvant PD1 had a partial response. The overall response rate to BRAF/MEKi was 75%, 3/4; to pembrolizumab in combination with an oral multitargeted receptor tyrosine kinase inhibitor, it was 22.2%, 2/9; to chemotherapeutic agents alone, it was 33.3%, 1/3; and to chemotherapeutic agents combined with pembrolizumab, it was 37.5%, 3/8. The patient treated with imatinib had progressive disease after 3 months of treatment. Of the 6 patients who received temozolomide combined with pembrolizumab, 3 (3/6, 50%) had a partial response. The median OS of the patients who relapsed locoregionally only was longer than that of the patients who relapsed distally at the first recurrence (35 months and 14 months, respectively; P < 0.01). The outcomes of the patients with disease recurrence during or after the completion of 1 year of adjuvant anti-PD1 therapy were poor despite multimodality treatment.
Mining definitions in Kissat with Kittens
Authors: Fleury Mathias , Biere Armin 
Published: April 2023

AbstractBounded variable elimination is one of the most important preprocessing techniques in SAT solving. It benefits from discovering functional dependencies in the form of definitions encoded in the CNF. While the common approach pioneered in SatELite relies on syntactic pattern matching, our new approach uses cores produced by an embedded SAT solver, Kitten. In contrast to a similar semantic technique implemented in Lingeling based on BDD algorithms to generate irredundant CNFs, our new approach is able to generate DRAT proofs. We further discuss design choices for our embedded SAT solver Kitten. Experiments with Kissat show the effectiveness of this approach.
Gender wage inequality: new evidence from penalized expectile regression
Authors: Bonaccolto-Töpfer Marina , Bonaccolto Giovanni 
Published: April 2023

AbstractThe Machado-Mata decomposition building on quantile regression has been extensively analyzed in the literature focusing on gender wage inequality. In this study, we generalize the Machado-Mata decomposition to the expectile regression framework, which, to the best of our knowledge, has never been applied in this strand of the literature. In contrast, in recent years, expectiles have gained increasing attention in other contexts as an alternative to traditional quantiles, providing useful statistical and computational properties. We flexibly deal with high-dimensional problems by employing the Least Absolute Shrinkage and Selection Operator. The empirical analysis focuses on the gender pay gap in Germany and Italy. We find that depending on the estimation approach (i.e. expectile or quantile regression) the results substantially differ along some regions of the wage distribution, whereas they are similar for others. From a policy perspective, this finding is important as it affects conclusions about glass ceiling and sticky floors.
Damage evolution of the coating/substrate system TiN/X2CrNi18-9 under high indentation loads: experimental and numerical study
Authors: Bahri Amir , Ellouz Manel , Klöcker Michaela , Elleuch Khaled , Kordisch Thomas 
Published: April 2023

AbstractHard coatings, in particular TiN, are widely used as coatings for cutting tools and in the agri-food industry. In the literature, however, few characterizations of hard coatings can be found which define the minimum applied load when the coating starts to fail. In the present study TiN coating was deposited on stainless steel X2CrNi18-9. Vickers and Brinell indentation tests with a wide load range were performed. The main results revealed that the increase of the applied load in Vickers and Brinell indentation influenced the coating and coating/substrate damage evolution. SEM investigation of the Vickers indentation area shows five modes of damage: inclined cracks, radial cracks, lateral cracks, edge cracks, and shear steps. Each damage mode occurs at a specific load range. Parallel cracks already appeared at the edges of the indents at the lowest load of 2 N. For Brinell indentation, cracks start in the coating only at loads higher than F = 307 N. The SEM examinations present damage modes such as circumferential cracks in the border and additional circular cracks in the center of the indent, creating a crack network. Numerical simulations of Brinell indentation were carried out in order to determine the stress distribution in the indent. The comparison of the numerical simulation results with the experimental findings revealed that the coating started to fail at a stress range above 5735 MPa which corresponds to a normal load range of higher than 307 N in Brinell indentation tests. At a load of 613 N cracks were observed.
GDF15 as a key disease target and biomarker: linking chronic lung diseases and ageing
Authors: Wan Yang , Fu Jianhua 
Published: April 2023

AbstractGrowth differentiation factor 15 (GDF15), a member of the transforming growth factor-beta superfamily, is expressed in several human organs. In particular, it is highly expressed in the placenta, prostate, and liver. The expression of GDF15 increases under cellular stress and pathological conditions. Although numerous transcription factors directly up-regulate the expression of GDF15, the receptors and downstream mediators of GDF15 signal transduction in most tissues have not yet been determined. Glial cell-derived neurotrophic factor family receptor α-like protein was recently identified as a specific receptor that plays a mediating role in anorexia. However, the specific receptors of GDF15 in other tissues and organs remain unclear. As a marker of cell stress, GDF15 appears to exert different effects under different pathological conditions. Cell senescence may be an important pathogenetic process and could be used to assess the progression of various lung diseases, including COVID-19. As a key member of the senescence-associated secretory phenotype protein repertoire, GDF15 seems to be associated with mitochondrial dysfunction, although the specific molecular mechanism linking GDF15 expression with ageing remains to be elucidated. Here, we focus on research progress linking GDF15 expression with the pathogenesis of various chronic lung diseases, including neonatal bronchopulmonary dysplasia, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and pulmonary hypertension, suggesting that GDF15 may be a key biomarker for diagnosis and prognosis. Thus, in this review, we aimed to provide new insights into the molecular biological mechanism and emerging clinical data associated with GDF15 in lung-related diseases, while highlighting promising research and clinical prospects.
A Lucas Critique of Mortgage Lending: Theory, Evidence, and Implications
Authors: Smith Brent C. , Yezer Anthony M. 
Published: April 2023

AbstractMortgage risk assessment is based on hazard models using data on “seasoned” mortgages, endorsed in previous years. These models assume that the lender’s pricing decision has no effect on the parameters of the hazard function. This paper argues that, when indicators of creditworthiness that can be influenced by applicants have a significant effect on credit cost, applicants behave strategically to influence the information disclosed to lenders. This gives rise to a Lucas Critique in which models generally perform well but occasionally fail because applicants are able and motivated to behave strategically.
Thrombus containing lesions strategies during primary percutaneous coronary interventions in ST-segment elevation myocardial infarction: insights from ORPKI National Registry
Authors: Rakowski Tomasz , Węgiel Michał , Malinowski Krzysztof P. , Siudak Zbigniew , Zasada Wojciech , Zdzierak Barbara , Tokarek Tomasz , Rzeszutko Łukasz , Dudek Dariusz , Bartuś Stanisław , Surdacki Andrzej , Dziewierz Artur 
Published: April 2023

AbstractIn the era of potent P2Y12 inhibitors, according to current guidelines, treatment with glycoprotein IIb/IIIa inhibitors (GPIs) should be limited to bail-out and/or highly thrombotic situations. Similarly, the recommendation for aspiration thrombectomy (AT) is downgraded to very selective use. We examine the prevalence, and predictors of GPI and AT use in STEMI patients referred to primary percutaneous coronary intervention (PCI). Data on 116,873 consecutive STEMI patients referred to primary PCI in Poland between 2015 and 2020 were analyzed. GPIs were administered in 29.3%, AT was used in 11.6%, and combined treatment with both in 6.1%. There was a mild trend toward a decrease in GPI and AT usage during the analyzed years. On the contrary, there was a rapid growth of the ticagrelor/prasugrel usage rate from 6.5 to 48.1%. Occluded infarct-related artery at baseline and no-reflow during PCI were the strongest predictors of GPI administration (OR 2.3; 95% CI 2.22–2.38 and OR 3.47; 95% CI 3.13–3.84, respectively) and combined usage of GPI and AT (OR 4.4; 95% CI 4.08–4.8 and OR 3.49; 95% CI 3.08–3.95 respectively) in a multivariate logistic regression model. Similarly, the administration of ticagrelor/prasugrel was an independent predictor of both adjunctive treatment strategies. In STEMI patients in Poland, GPIs are selectively used in one in four patients during primary PCI, and the combined usage of GPI and AT is marginal. Despite the rapid growth in potent P2Y12 inhibitors usage in recent years, GPIs are selectively used at a stable rate during PCI in highly thrombotic lesions.
On Damping of Plasmons and Plasmon-Polaritons in Metallic Nanostructures and Its Influence onto Numerical Simulations
Authors: Krzemińska Zofia , Jacak Janusz E. , Jacak Witold A. 
Published: April 2023

AbstractWe show that the damping of plasmons in metallic nanoparticles highly exceeds that caused by scattering of electrons on defects, phonons, and other electrons and on boundaries of particles. The radiation losses in far-field zone due to the Lorentz friction is especially high at nanometre scale of metal confinement (e.g. attains the maximum at ca. 100 nm diameter of particle, Au in vacuum). This causes a different e-m response of such size structures in comparison to conventional solution of Maxwell-Fresnel equations using the bulk dielectric function for metal. The strong discrepancy occurs also if plasmons are coupled in near-field zone to nearby-located absorbing medium, e.g. semiconductor substrate. This coupling cannot be accounted for by classical electrodynamic treatment (e.g. by numerical solution of Maxwell equations by finite element method for differential equation solution) and needs the application of quantum Fermi golden rule to estimate plasmon damping and related modifications of dielectric functions both of metallic nanoparticles and of absorbing medium. Similarly, the perfect cancellation of radiative losses of plasmon-polaritons in metallic nano-chains is beyond classical Maxwell equation modelling, as it reveals the perfect vanishing of Lorentz friction losses in chain segments by radiative contribution from other segments in near-, medium- and far-field zones. This demonstrates that nano-plasmonic effects cannot be reliably numerically modelled using material parameters from conventional packets referred to optical constants measured in bulk.