bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of microencapsulated cocoa intake on muscle recovery, inflammation, and oxidative stress after exercise-induced muscle damage
Authors: Junior Olavo Ramos , Souza Karen , Tavares Isabela Ribeiro Grangeira , de Oliveira Gustavo Vieira , Alvares Thiago Silveira 
Published: December 2022

Abstract
The exercise-induced muscle damage is associated with symptoms such as inflammation, delayed onset muscle soreness and impaired muscle performance. Cocoa polyphenols intake has been suggested to improve muscle recovery due to their antioxidant and anti-inflammatory capacity. However, its bioavailability is challenging. Therefore, food microencapsulation may be an alternative to protect polyphenols, ensuring biological effects. This study aimed to investigate the effect of a single dose of microencapsulated cocoa intake on the changes in muscle damage markers after eccentric exercise. In this randomized, double-blind, crossover design study, fourteen healthy volunteers with previous resistance training experience performed 6 x 10 maximal isokinetic eccentric contractions of the elbow flexors using an isokinetic dynamometer after ingesting 25g of microencapsulated cocoa or placebo. Peak isometric torque was measured by maximal voluntary isometric contractions and pain by visual analogic scale before, 24h, 48h and 72h after damage protocol. Plasma glutathione and malondialdehyde levels were measured using high-performance liquid chromatography, and myoglobin and C-reactive protein were determined by a fluorescence immunoassay analyzer. Significant decreases were seen in peak isometric torque and pain measures from pre to 72h post eccentric exercise. A significant main effect for time was found only for plasma myoglobin at 2h, 48h, and 72h, and 2h for C-reactive protein compared to pre values. No significant time x treatment effects were observed (all p > 0.05). This study demonstrated that microencapsulated cocoa could not improve muscle recovery after eccentric exercise, at least when consumed in a single dose.
Primary ureteroscopy for proximal ureteral stones
Authors: Lazarovich Alon , Shvero Asaf , Zillberman Dorit E , Dotan Zohar , Winkler Harry , Kleinmann Nir 
Published: December 2022

Abstract
Purpose

Primary Ureteroscopy & Laser Lithotripsy is the treatment of choice for distal ureteral stones. However, in cases of proximal ureteral stones some urologists recommend preliminary insertion of a Double J ureteral stent (DJS) and deferred Ureteroscopy. We aim to evaluate the necessity of preliminary DJS insertion in proximal ureteral stones management, by comparing the surgical outcome of patients undergoing primary ureteroscopy and laser lithotripsy for proximal Vs. distal ureteral stones.

Patients and Methods

Medical records of patients who underwent ureteroscopy between January to December 2016 in our institution were reviewed. Data collected included: demographic data, stone size, renal function, intra and post-operative complications, stone free rate (SFR). Patients were divided into 2 groups: Proximal ureteral stones and Distal ureteral stones.

Results

This cohort included 241 patients who underwent ureteroscopy, among them 106 had a proximal ureteral stone. Median age was 51 years. Patients who underwent ureteroscopy for proximal ureteral stone were significantly older: 54.68 vs.49.2 (p = 0.007). The median stone maximal diameter was 7 mm, the proximal ureteral stones were larger with borderline statistical significance (p = 0.07). The complication rate and stone free rate (SFR) was similar among both groups (p = 0.657 and p = 1, respectively). The Prevalence of post procedural DJS insertion was higher among patients who underwent ureteroscopy for proximal ureteral stone: 92.5% Vs. 79.3% (p = 0.004).

Conclusions

Our study concludes that primary ureteroscopy and laser lithotripsy for proximal ureteral stones is a valid and feasible treatment with similar surgical outcome compared to distal ureteral stones. Preliminary DJS insertion seems to be unnecessary.
A comparative analysis on adaptation behavior and failure risk of femurs of different qualities under the effect of direct transfemoral fixations
Authors: Omidvar Armin , Soheilifard Reza , Kowsar Sara 
Published: December 2022

Abstract
Osseointegrated transfemoral prostheses secure the direct attachment of prosthetic limbs. Despite the existence of relevant studies concerning these fixations, the effect of bone quality on their outcome has not been thoroughly investigated. In this study, the finite element (FE) analysis was linked to a bone remodeling algorithm to simulate the bone adaptation process. The 3D models of femurs with average shaft diameters of 24mm, 26mm, and 28mm were created based on computerized tomography (CT) scan images. Three initial densities representing high, moderate, and low-density femurs were also modeled based on the available data in the literature. Eventually, the effect of bone quality was evaluated in terms of bone adaptation and failure risk. The analysis revealed that the dissimilarities in bone quality considerably affect the bone mineral density (BMD) changes and stress distribution in the implantation area. The presence of transfemoral implants increased the interface failure risk at the distal zones for low-quality femurs while decreasing the failure risk at the proximal zones. It was also shown that the chance of fracture and interface failure is lower for dense femurs, and the remodeling process does not significantly affect their failure risk.
Impact of Persistent Organic Pollutants on AIDS progression and all-cause mortality. A longitudinal study in HIV-2 infected individuals in Guinea-Bissau
Authors: Lindman Jacob , Ström Kajsa , Månsson Fredrik , Biague Antonio , Silva Zacarias José da , Esbjörnsson Joakim , Jansson Marianne , Medstrand Patrik , Jakobsson Kristina , Norrgren Hans 
Published: December 2022

Abstract
Background: Persistent organic pollutants (POPs) may be harmful to human health. In a previous study we found high levels of organochlorine (OC) pesticides in an occupational cohort in Guinea-Bissau. We investigated if POP levels in serum were associated with clinical progression to AIDS and mortality in individuals infected with HIV-2, an AIDS-causing virus that is circulating in West Africa.
Methods: We selected HIV-2 infected individuals entering an open prospective cohort of police officers in Guinea-Bissau between 1990 and 1996, who progressed to AIDS within five years after inclusion (progressors, n=30). For comparison, HIV-2 infected individuals without AIDS during at least five years of follow-up were selected (non-progressors, n=52). Biobanked sera were analysed for 22 POPs, including OC pesticides and polychlorinated biphenyls (PCB). Associations of individual POP concentrations with the development of AIDS within 5 years were first evaluated with logistic regression adjusted for age and sex. Cox proportional hazard models adjusting for age and sex were then used to determine associations between POPs and progression to AIDS or all-cause mortality during prolonged follow-up that continued until 2013.
Results: High serum levels of OC pesticides were detected at cohort entry. The development of AIDS was not related to baseline serum POP levels. During prolonged follow-up, 58 individuals developed AIDS (71%) and 53 died (65%). An increased risk for all-cause mortality was observed for beta- hexachlorocyclohexane (HR 1.35, 95%CI 1.01-1,82), p,p´-DDT (HR 1.32, 95%CI 0.99-1.77) and p,p´-DDE (HR 1.34, 95%CI 0.99-1.81). Eight PCBs were also evaluated without any association with development of AIDS or all-cause mortality.
Conclusions: An association was indicated between higher levels of OC pesticides and increased all-cause mortality risk, but not with progression to AIDS among HIV-2 infected individuals in Guinea-Bissau, West Africa. Our results reinforce that public health actions should be considered to minimize exposure to OC pesticides.
An ANN-assisted efficient enriched finite element method via the selective enrichment of moment fitting
Authors: Lee Semin , Kang Taehun , Jung Im Doo , Ji Wooseok , Chung Hayoung 
Published: December 2022

Abstract
Enrichment techniques that employ nonconforming mesh are effective in modeling structures with discontinuities because numerical issues regarding mesh quality are avoided. However, the accurate integration of the bilinear and linear forms on the discretized domain, which is required in the standard Galerkin-based finite element method, is computationally expensive due to the complexity of the enriched basis function. In this paper, we present a fast and accurate alternative method of numerical integration using nonlinear regression enabled by a multi-perceptron feedforward neural network. The relationship between an implicitly represented geometry and the quadrature rule derived from the moment fitting method is predicted by the neural network; the neural network-based regression model circumvents complex computation and significantly reduces the overall online time by avoiding expensive function evaluations. Through the selected numerical examples, we demonstrate the efficiency and accuracy of the current method, as well as the flexibility of the trained network to be used in different contexts.
CUX1-related neurodevelopmental disorder: Deep insights into phenotype-genotype spectrum and underlying pathology
Authors: Oppermann Henry , Marcos-Grañeda Elia , Weiss Linnea , Gurnett Christina , Jelsig Anne Marie , Vineke Susanne , Isidor Bertrand , Mercier Sandra , Magnussen Kari , Zacher Pia , Hashim Mona , Pagnamenta Alistair , Race Simone , Srivast Siddharth , Frazier Zoë , Maiwald Robert , Pergande Matthias , Milani Donatella , Rinelli Martina , Levy Jonathan , Krey Ilona , Fontana Paolo , Lonardo Fortunato , Riley Stephanie , Kretzer Jasmine , Rankin Julia , Reis Linda , Semina Elena , Reuter Miriam , Scherer Stephen , Iascone Maria , Weis Denisa , Fagerberg Christina , Brasch-Andersen Charlotte , Hansen Lars , Kuechler Alma , Noble Nathan , Gardham Alice , Tenney Jessica , Rathore Geetanjali , Beck-Woedl Stefanie , Haack Tobias , Pavlidou Despina , Atallah Isis , Vodopiutz Julia , Janecke Andreas , Lemke Johannes , Jamra Rami Abou , Nieto Marta , Tümer Zeynep , Platzer Konrad 
Published: December 2022

Abstract
Heterozygous, pathogenic CUX1 variants are associated with global developmental delay or intellectual disability. This study delineates the clinical presentation in an extended cohort and investigates the molecular mechanism underlying the disorder in a Cux1+/− mouse model. Through international collaboration, we assembled the phenotypic and molecular information for 34 individuals (23 unpublished cases). A Cux1+/− mouse model was used to analyze CUX1 expression in the brain and evaluate susceptibility to epilepsy. We describe 34 patients with 26 different null and four missense variants. The leading symptoms were mild to moderate delayed speech and motor development, and intellectual disability. In Cux1+/− mice, we found delayed growth, histologically normal brains, and increased susceptibility to seizures. In Cux1+/− brains, the expression of Cux1 transcripts was half of WT animals. Expression of CUX1 proteins was also reduced, although in early postnatal animals significantly more than in adults. In summary, disease-causing CUX1 variants result in a non-syndromic phenotype of developmental delay and intellectual disability. In some patients, this phenotype ameliorates with age, resulting in a clinical catch-up and normal IQ in adulthood. Furthermore, the balance of CUX1 isoform expression in the brain during development appears to be important for this favorable clinical course.
Die Entsperrung und Spiegelung von passwortgeschützten Datenträgern im Siegelungsverfahren
Authors: Reimann Martin 
Published: December 2022

Mit seinem Urteil BGE 148 IV 221 hat das Bundesgericht die Praxis der Beschwerdekammer des Bundesstrafgerichts, wonach die Entsperrung und Spiegelung passwortgeschützter Datenträger im Rahmen eines Siegelungsverfahrens durch die Untersuchungsbehörde vorgenommen bzw. an die Forensikabteilung des Bundesamtes für Polizei (fedpol) delegiert werden kann, für bundesrechtswidrig erklärt. Auch wenn der Entscheid des Bundesgerichts im Ergebnis nicht zu beanstanden ist, wirft er mit Bezug auf künftige Siegelungsverfahren verschiedene Fragen auf, die im vorliegenden Beitrag im Anschluss an eine Zusammenfassung der bundesgerichtlichen Erwägungen erörtert werden.
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Dans son arrêt ATF 148 IV 221, le Tribunal fédéral a déclaré contraire au droit fédéral la pratique de la Cour des plaintes du Tribunal pénal fédéral selon laquelle l'autorité d'instruction peut, dans le cadre d'une procédure d'apposition de scellés, procéder à la copie-miroir de supports de données protégés par un mot de passe ou déléguer ces tâches à la division forensique de l'Office fédéral de la police (fedpol). Bien que le résultat de cette décision ne soit pas critiquable, elle soulève plusieurs questions en ce qui concerne les futures procédures de scellés. Ces questions sont abordées dans cet article, après un résumé des considérants de l'arrêt.
Towards the hydraulics of the hydroinformatics era
Authors: Abbott M.B. , Babovic V.M. , Cunge J.A. 
Published: December 2022

Summary
Hydroinformatics is the study of the flows of knowledge and data related to the flow of water and all that it transports, together with interactions with both natural and man-made, or artificial, environments (Abbott, 1991). Hydraulics, understood as the study of flows of water, more recently extended to include the transport of matter in all its forms with these flows, is accordingly central to hydroinformatics. Without hydraulics, no hydroinformatics! From this situation it may at first appear as though hydroinformatics provides only a new periphery to hydraulics: a new way of transmitting hydraulics knowledge and data to society. In practice, however, the way in which hydraulics is viewed and practised is itself now changing as a result of its incorporation into the new paradigm that hydroinformatics provides. The first purpose of the present paper is to introduce some of the changes that are currently proceeding in hydraulics under the influence of developments occurring in hydroinformatics. The second purpose is to indicate the consequences of these changes for the application of hydraulics with in society, and thus for the future direction of hydraulics and hydroinformatics themselves.
Preparation of magnetic biochar and its catalytic role in degradation of Cu-EDTA by heterogeneous Fenton reaction
Authors: Jiang Yu , Liu Xinyu , Huang Shikai , Wu Huifang , Liu Haiyan , Liu Shenzhe , Xu Jiale , Wang Kun 
Published: December 2022

AbstractIn this study, magnetic biochar (Fe-BC) was synthesized from phoenix tree leaves and FeSO4·7H2O by impregnation-pyrolysis method, and was used to activate H2O2 to degrade Cu-EDTA. The effects of preparation parameters on the degradation of Cu-EDTA by Fe-BC/H2O2 system were investigated by degradation experiments and characterization methods (SEM, BET, FTIR, XRD and XPS). The results showed that the magnetic biochar prepared under the pyrolysis temperature of 400 °C, pyrolysis time of 3 h and iron content of 3 wt% had the best catalytic activity. Within 120 min, the breaking efficiency of Cu-EDTA binding, precipitation efficiency of Cu2+ and removal efficiency of TOC could reach 78.48, 71.65 and 46.54% at the conditions of adding 1.0 g/L magnetic biochar and 25 mM H2O2 and the iron dissolution was only 0.32 mg/L. The characterization results and comparison experiments demonstrated that the catalytic effect of magnetic biochar not only depends on the transfer of electrons to H2O2 by the loaded iron oxides, but also the active oxygen functional groups (OFGs) and persistent free radicals (PFRs) contained on the surface can transfer electrons to H2O2 or even dissolved oxygen to produce an amount of hydroxyl radicals (·OH) and superoxide anion radicals ().
Experimental Animal Models: Tools to Investigate Antidiabetic Activity
Authors: Jain Akhlesh Kumar , Madhariya Rashmi , Dixena Bhupendra , Ram Alpana , Vyas Amber 
Published: December 2022

Abstract:About 2.8% of the global population are being suffered from Diabetes mellitus. Diabetes mellitus is a group of metabolic disorders that is characterized by an absolute lack of insulin and resulting in hyperglycemia. To overcome the challenges, many antidiabetic drugs are being used, and research is being carried out in search of more effective anti-diabetic drugs. To study the effectiveness of antidiabetic drugs, many diabetic models, chemicals, and diabetogenic hormones were used at the research level. In this review, we summarised various animal models used, chemicals that induce diabetes, their properties, and the mechanism of action of these models. Further, diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic manipulations. To better understand both the pathogenesis and potential therapeutic agents, appropriate animal models of type 1 & type 2 diabetes mellitus are needed. However, for an animal model to have relevance to the study of diabetes, either the characteristics of the animal model should mirror the pathophysiology and natural history of diabetes or the model should develop complications of diabetes with an etiology similar to that of the human condition. There appears to be no single animal model that encompasses all of these characteristics, but there are many that provide very similar characteristics in one or more aspects of diabetes in humans. The use of the appropriate animal model based on these similarities can provide much-needed data on pathophysiological mechanisms operative in human diabetes.
Effectiveness of HM-3-HSA on Inhibiting Cancer Cell Migration and
Metastasis
Authors: Yang Hui , Li Ting , Wang Ruyue , Li Kaike , Wang Peiya , Zhao Jiang , Guo Qi , Zhang Jun , Li Yang , Li Hongyu 
Published: December 2022

Background:
Metastasis is the major cause of treatment failure in cancer patients and cancer-associated death, and an antimetastatic drug would be a beneficial therapy for cancer patients. HM-3-HSA is a fusion protein which improved the pharmacokinetics of HM-3 and exerted antitumor and anti-angiogenesis activity in multiple tumor models. However, the efficacy of HM-3-HSA in cancer cell migration and metastasis has not been elucidated.

Materials and methods:
Herein, high-cell density fermentation of Pichiapink strain expressing HM-3-HSA was performed for the first time. Then, the desired protein was purified by Butyl Sepharose High performance, Capto Blue, Phenyl Sepharose 6FF HS and DEAE Sepharose FF. Furthermore, the effect of HM-3-HSA on the migration and invasion of cancer cells was also evaluated, and B16F10 metastasis model was established to detected the anti- metastasis effect of HM-3-HSA in vivo.

Conclusion:
The results indicated that the yield of HM-3-HSA was 320 mg/L in a 10 L fermenter, which was a 46% increase over that expressed in flask cultivation. The desired protein was purified by four-step, which yielded a 40% recovery of a product that had over 99% purity. Purified HM-3-HSA significantly suppressed the migration and invasion of HCT-116, SMMC-7721 and B16F10 cell lines. On the other hand, in the B16F10 metastasis model, HM-3-HSA significantly inhibited pulmonary metastases of B16F10 cells, suggesting that HM-3-HSA exerted the anti-metastasis effect in vivo
Antiviral Activity of Pyrimidine Containing Compounds: Patent Review
Authors: Farghaly Thoraya A. , Harras Marwa F. , Alsaedi Amani M.R. , Thakir Halima A. , Mahmoud Huda K. , Katowah Dina F. 
Published: December 2022

Abstract:
Viruses are still the most prevalent infectious pathogens on a worldwide scale, with many
of them causing life-threatening illnesses in humans. Influenza viruses, because of their significant
morbidity and mortality, continue to pose a major threat to human health. According to WHO statistics,
seasonal influenza virus epidemics are predicted to cause over 2 million severe illness cases with
high death rates yearly. The whole world has been suffering from the COVID-19 epidemic for two
years and is still suffering so far, and the deaths from this virus have exceeded three million cases.
Because the great majority of viral infections do not have a specific medication or vaccination, discovering
novel medicines remains a vital task. This review covers reports in the patent literature from
1980 to the end of 2021 on the antiviral activities of pyrimidine moieties. The patent database,
SciFinder, was used to locate patent applications. A large variety of pyrimidine molecules have been
produced and tested for antiviral activity over the last decade. These molecules were reported to inhibit
a wide range of viruses, including influenza virus, respiratory syncytial virus, rhinovirus, dengue
virus, herpes virus, hepatitis B and C, and human immunodeficiency virus. The cytotoxicity of the
developed pyrimidine derivatives was tested in almost all reported studies and the selectivity index
was calculated to show the selectivity and safety of such molecules. From the remarkable activity of
pyrimidine compounds as antivirals for several dangerous viruses, we expect that these derivatives
will be used as potent drugs in the very near future.
A Glimpse at the Quinoline-Hybridization Approach for the Development
of New Antimalarials
Authors: Kaur Sukhbir , Kaur Amanjot , Arora Amandeep , Kumar Vipan 
Published: December 2022

Abstract:
One of the most fatal infectious diseases, malaria, still poses a threat to about half of the world's population and is the leading cause of death worldwide. The use of artemisinin-based combination therapy has helped to significantly reduce the number of deaths caused by malaria, but the emergence of drug resistance threatens to undo this gain. In a bid to boost adherence, several new combination therapies with effectiveness against drug-resistant parasites are currently being tested in clinical settings. Nevertheless, notwithstanding these gains, malaria must be completely eradicated by a concerted international effort on several fronts. Quinoline-based compounds were the cornerstone of malaria chemotherapy until recently when resistance to these drugs severely hampered efforts to achieve a "Zero Malaria" world. The inappropriate use of available antimalarials is one of the factors responsible for resistance development and treatment failure, warranting the search for new chemical entities and alternative approaches to combat this threat. A vast number of solutions have emerged and one of them, quinoline-hybridization, is an effective method for introducing structural diversity, resulting in molecules with improved biological activities, reduced drug resistance, fewer drug-drug interactions, and improved safety and pharmacokinetic profiles. Choosing the ideal target combination and achieving a balanced activity toward them while preserving drug-like properties are the key challenges in the development of molecular hybrids. This review examines the highlights of quinoline hybridization, with some of the hybrids exhibiting remarkable in vitro and in vivo activities, emphasizing that it is a useful method for developing new anti-malarial lead compounds.