bluuebunny/crossref_metadata_2025_split huggingface dataset:
Communs et dynamiques de pouvoir dans l’Europe du Sud médiévale
Authors: Viso Iñaki Martín , Rao Riccardo 
Published: January 2023

Cet article propose une analyse comparée de l’évolution des communs dans deux grandes régions de l’Europe méridionale médiévale : l’Italie du centre-nord et le plateau du Duero dans la Péninsule ibérique. Au cours des dernières années, les recherches menées à partir des études économiques d’Elinor Ostrom sur différentes régions d’Europe du Nord ont insisté sur la centralité des communs dans l’agrosystème et l’organisation des communautés depuis le haut Moyen Âge. Face à une Europe du Nord résiliente, où la présence de biens communs stables a permis de résorber les inégalités sociales, les communs en Europe du Sud auraient été moins solides, entraînant une moindre cohésion des communautés. L’étude comparative de longue durée des deux régions met en évidence l’existence de biens communs dès le début du Moyen Âge, puis leurs évolutions successives au Moyen Âge central et au bas Moyen Âge, en même temps que les pratiques documentaires qui les ont enregistrés. Cette résilience a pris des formes différentes dans chacune des régions, en raison de facteurs contingents tout aussi divers. Partie prenante d’une « économie morale », les biens communaux ont donc pu s’adapter à des conditions changeantes et à la présence de nouveaux acteurs sociaux. Finalement, ces formes d’utilisation collective, en dialogue constant avec les notions de propriété et d’appropriation, étaient liées à la création et à la pérennité d’identités (rurales, urbaines) opérant à différentes échelles.
Hinge Communitarianism
Authors: Mion Giovanni 
Published: January 2023

AbstractIn this paper, I will defend a communitarian perspective on the so-called “hinge propositions” (hinges, for short). Accordingly, I will argue that hinges play a normative role, in the sense that, among other things, they govern the mechanisms of social inclusion/exclusion. In particular, I will examine the so-called “religious hinges”; and I will argue that such hinges, being the product of mere indoctrination, are particularly effective in shaping boundaries among communities. Finally, with the help of Peter Munz's theory of altruism, I will attempt to explain why religious hinges play the role they do.
On the prudence of adopting a ‘Sin now; repent later’ policy
Authors: Mawson T. J. 
Published: January 2023

Abstract‘Listen, I'm against sin. I'll kick it as long as I've got a foot; I'll punch it as long as I've got a fist; I'll butt it as long as I've got a head; and I'll bite it as long as I've got a tooth’ (Billy Sunday). Billy Sunday was a revivalist preacher in the early half of the twentieth century. I take it that Billy's approach to sin will be taken by most to be more theologically acceptable than the following. ‘I figure I'll go for the life of sin, followed by the presto-change-o deathbed repentance’ (Bart Simpson). Bart Simpson is a character in the animated TV Show, The Simpsons. In the vignette from which this quotation of Bart's is abstracted, Bart is actually in conversation with a Billy-Sunday-like preacher. The preacher, on hearing of Bart's theology (Bartian theology, we may call it; not, NB Barthian theology), replies in a slightly stunned way, as if he had never himself considered Bartianism prior to that particular moment, ‘Wow! That is a good angle. . .’ However, he quickly collects himself and adds definitively, ‘But it's not God's angle.’ In this article, I wish to explore Bart's angle; could it, or something like it, after all, be a prudent angle?
Calibrated analytical model for magnetic localization of wireless capsule endoscope based on onboard sensing
Authors: Li You , Huang Zhuokang , Liu Xiaobo , Jie Yu , Song Chaoyang , Hu Chengzhi 
Published: January 2023

AbstractWireless capsule endoscopes (WCEs) are pill-sized camera-embedded devices that can provide visualization of the gastrointestinal (GI) tract by capturing and transmitting images to an external receiver. Determination of the exact location of the WCE is crucial for the accurate navigation of the WCE through external guidance, tracking of the GI abnormality, and the treatment of the detected disease. Despite the enormous progress in the real-time tracking of the WCE, a well-calibrated analytical model is still missing for the accurate localization of WCEs by the measurements from different onboard sensing units. In this paper, a well-calibrated analytical model for the magnetic localization of the WCE was established by optimizing the magnetic moment in the magnetic dipole model. The Jacobian-based iterative method was employed to solve the position of the WCE. An error model was established and experimentally verified for the analysis and prediction of the localization errors caused by inaccurate measurements from the magnetic field sensor. The assessment of the real-time localization of the WCE was performed via experimental trials using an external permanent magnet (EPM) mounted on a robotic manipulator and a WCE equipped with a 3-axis magnetic field sensor and an inertial measurement unit (IMU). The localization errors were measured under different translational and rotational motion modes and working spaces. The results showed that the selection of workspace (distance relative to the EPM) could lead to different positioning errors. The proposed magnetic localization method holds great potential for the real-time localization of WCEs when performing complex motions during GI diagnosis.
Does Performance Competition Impact China's Leadership Behaviour? Re-examining the Promotion Tournament Hypothesis
Authors: Pang Baoqing , Keng Shu , Zhang Siyi 
Published: January 2023

AbstractHow can China develop so quickly and yet maintain stability? Most scholars pinpoint the efforts of China's local government leaders as a primary factor. Regarding what motivates these leaders, however, scholars display wide disagreement. The widely accepted “promotion tournament” hypothesis stresses competition among local leaders as the driving force, but empirical test results vary considerably and create controversy. We argue that tests of promotion competition should target leadership behaviour rather than institutional inducements; the latter are, at best, a necessary condition of the former. Informed by extensive fieldwork, this study proposes an alternative and more direct approach to verifying the promotion tournament hypothesis by examining the impacts of promotion competition on leaders’ performance efforts. Our test results show, however, that competition for promotion has no significant impact on local leaders’ behaviour, thereby indicating that the promotion tournament hypothesis cannot be the primary explanation for China's economic achievements and regime resilience. In so doing, our study illuminates the oversimplified assumptions behind a prevailing proposition in Chinese politics and offers empirically informed insights into the tensions between political institutions and leadership behaviour.
Gender and Political Representation in Times of Crisis
Authors: O’Brien Diana Z. , Piscopo Jennifer M. 
Published: January 2023

AbstractPolitics is increasingly dominated by crises, from pandemics to extreme weather events. These Critical Perspectives essays analyze crises’ gendered implications by focusing on their consequences for women’s descriptive and substantive representation. Covering multiple kinds of crises, including large-scale protests, climate shocks, and war and revolution, the contributions reveal three factors shaping both the theoretical conceptualization and empirical analysis of crisis and women’s representation: (1) the type of crisis, (2) the actors influenced by the crisis, and (3) the aftermath of the crisis. Together, the contributors urge scholars to “think crisis, think gender” far beyond the supply of and demand for women leaders.
Epochal Changes in the Intrinsic Nature/Dynamics of Flood and Drought During Indian Summer Monsoon
Authors: Maurya Archana , Verma Shruti , Pant Manas , Bhatla R. 
Published: January 2023

AbstractThe basic and derived meteorological parameters, are important factors that affect the epochal changes of monsoonal drought/flood events which consequently influence the socio‐economic aspects of India. The anomalous tricade departure of parameters namely rainfall, surface pressure, surface temperature, zonal and meridional wind, cloud cover (CC), outgoing longwave radiation, latent heat flux (LHF), sensible heat flux, net incoming shortwave radiation flux and net heat flux (NHF) have been considered between past, and recent tricade respectively drought and flood events. An anomalous decrease (−3 to −2 mm/d) in rainfall over the southern Arabian sea (AS), southern peninsular India and Bay of Bengal during past and recent tricade, on the other side increase (2–2.5 mm/d) in rainfall over the equatorial Indian ocean (EIO) during drought. The drought episode of the recent tricade is showing basin wise significant increase in LHF (20–30 W/m2) and decrease in NHF (−30 to −60 W/m2) from the Somali coast to Indonesian region which is linked with changing oceanic processes linked with the Indian ocean warming. The comparison of past and recent monsoonal flood has shown decrease in the CC over EIO and AS region which supported anomalous highest departure in LHF (12 W/m2) over EIO. A direct association of dry and moist static energy variations have been found to be linked with the surface fluxes during Indian summer monsoon season. Further, epochal differences of vertically integrated moisture flux convergence is consistent with flood/drought rainfall anomaly. Thus, radiative imbalance also plays a secondary role in determining epochal nature of drought/flood variability and its nature.
Discrete Element Modeling of Southeast Asia's 3D Lithospheric Deformation During the Indian Collision
Authors: Jiao Liqing , Tapponnier Paul , Donzé Frédéric‐Victor , Scholtès Luc , Gaudemer Yves , Xu Xiwei 
Published: January 2023

AbstractThe Indian collision has deformed the eastern Asian continent in a multifaceted way, uplifting Tibet and surrounding mountains, activating ≥1,000 km‐long strike‐slip faults, and opening Tertiary rifts and oceanic basins up to ≈3,000 km away from the Himalayas. Modeling such broad‐scale tectonics has been challenging. While continent‐scale, lithospheric deformation appears to have been primarily taken‐up by long, narrow, inter‐connected shear‐zones with large offsets, the contribution of processes such as channel‐flow, collapse, delamination, etc… has remained contentious. Here, based on increasing 4G (Geological, Geophysical, Geochronological, Geodetic) evidence including kinematic and timing constraints on the main mechanisms at play, we use Discrete Element (DE) Modeling to simulate and further understand the evolution of 3D strain across east Asia since the onset of collision, ≈55 Ma ago. The planar, 50 million km2, 125 km‐thick models are scaled for gravity. The approach permits mega‐fault generation and evolution without pre‐arranged initial settings. The results provide insight into fault birth, propagation and motion, as well as mountain building and plateau growth. They corroborate that continental crustal thickening across Tibet alternated with the extrusion of large blocks that rifted apart in the far field. Remarkably, without changes in boundary conditions or indentation rate, the DE model also vindicates slip reversal along initial strike‐slip shear zones.
Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma
Authors: Kurata Keiji , James-Bott Anna , Tye Mark A. , Yamamoto Leona , Samur Mehmet K. , Tai Yu-Tzu , Dunford James , Johansson Catrine , Senbabaoglu Filiz , Philpott Martin , Palmer Charlotte , Ramasamy Karthik , Gooding Sarah , Smilova Mihaela , Gaeta Giorgia , Guo Manman , Christianson John C. , Payne N. Connor , Singh Kritika , Karagoz Kubra , Stokes Matthew E. , Ortiz Maria , Hagner Patrick , Thakurta Anjan , Cribbs Adam , Mazitschek Ralph , Hideshima Teru , Anderson Kenneth C. , Oppermann Udo 
Published: January 2023

AbstractMultiple myeloma (MM) is a plasma cell malignancy characterised by aberrant production of immunoglobulins requiring survival mechanisms to adapt to proteotoxic stress. We here show that glutamyl-prolyl-tRNA synthetase (GluProRS) inhibition constitutes a novel therapeutic target. Genomic data suggest that GluProRS promotes disease progression and is associated with poor prognosis, while downregulation in MM cells triggers apoptosis. We developed NCP26, a novel ATP-competitive ProRS inhibitor that demonstrates significant anti-tumour activity in multiple in vitro and in vivo systems and overcomes metabolic adaptation observed with other inhibitor chemotypes. We demonstrate a complex phenotypic response involving protein quality control mechanisms that centers around the ribosome as an integrating hub. Using systems approaches, we identified multiple downregulated proline-rich motif-containing proteins as downstream effectors. These include CD138, transcription factors such as MYC, and transcription factor 3 (TCF3), which we establish as a novel determinant in MM pathobiology through functional and genomic validation. Our preclinical data therefore provide evidence that blockade of prolyl-aminoacylation evokes a complex pro-apoptotic response beyond the canonical integrated stress response and establish a framework for its evaluation in a clinical setting.
GWAS Explorer: an open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas
Authors: Machiela Mitchell J. , Huang Wen-Yi , Wong Wendy , Berndt Sonja I. , Sampson Joshua , De Almeida Jonas , Abubakar Mustapha , Hislop Jada , Chen Kai-Ling , Dagnall Casey , Diaz-Mayoral Norma , Ferrell Mary , Furr Michael , Gonzalez Alex , Hicks Belynda , Hubbard Aubrey K. , Hutchinson Amy , Jiang Kevin , Jones Kristine , Liu Jia , Loftfield Erikka , Loukissas Jennifer , Mabie Jerome , Merkle Shannon , Miller Eric , Minasian Lori M. , Nordgren Ellen , Park Brian , Pinsky Paul , Riley Thomas , Sandoval Lorena , Saxena Neeraj , Vogt Aurelie , Wang Jiahui , Williams Craig , Wright Patrick , Yeager Meredith , Zhu Bin , Zhu Claire , Chanock Stephen J. , Garcia-Closas Montserrat , Freedman Neal D. 
Published: January 2023

AbstractThe Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial is a prospective cohort study of nearly 155,000 U.S. volunteers aged 55–74 at enrollment in 1993–2001. We developed the PLCO Atlas Project, a large resource for multi-trait genome-wide association studies (GWAS), by genotyping participants with available DNA and genomic consent. Genotyping on high-density arrays and imputation was performed, and GWAS were conducted using a custom semi-automated pipeline. Association summary statistics were generated from a total of 110,562 participants of European, African and Asian ancestry. Application programming interfaces (APIs) and open-source software development kits (SKDs) enable exploring, visualizing and open data access through the PLCO Atlas GWAS Explorer website, promoting Findable, Accessible, Interoperable, and Re-usable (FAIR) principles. Currently the GWAS Explorer hosts association data for 90 traits and >78,000,000 genomic markers, focusing on cancer and cancer-related phenotypes. New traits will be posted as association data becomes available. The PLCO Atlas is a FAIR resource of high-quality genetic and phenotypic data with many potential reuse opportunities for cancer research and genetic epidemiology.
Lipidomic alterations in human saliva from cystic fibrosis patients
Authors: Caterino Marianna , Fedele Roberta , Carnovale Vincenzo , Castaldo Alice , Gelzo Monica , Iacotucci Paola , Ruoppolo Margherita , Castaldo Giuseppe 
Published: January 2023

AbstractCystic fibrosis is a hereditary metabolic disorder characterized by impaired traffic of chloride ions and water through membranes of the respiratory and gastrointestinal, that causes inadequate hydration of airway surfaces, dehydrated mucous secretions and a high-sodium chloride sweat. Although the classical presentation of the condition is well known, a better characterization of metabolic alterations related is need. In particular, the metabolic composition alterations of biological fluids may be influence by the disease state and could be captured as putative signature to set targeted therapeutic strategies. A targeted comprehensive mass spectrometry-based platform was employed to dissect the lipid content of saliva samples form CF patients, in order to investigate alterations in the lipid metabolic homeostasis related to the pathology, chronic obstructive pulmonary disease, Pseudomonas Aeruginosa infection, pancreatic insufficiency, liver disfunction and diabetes-related complications.
An untargeted metabolomic approach to investigate antiviral defence mechanisms in memory leukocytes secreting anti-SARS-CoV-2 IgG in vitro
Authors: Federica Gevi , Giuseppina Fanelli , Veronica Lelli , Gianpaolo Zarletti , Massimo Tiberi , Veronica De Molfetta , Giuseppe Scapigliati , Maria Timperio Anna 
Published: January 2023

AbstractEvidence shows that individuals infected by SARS-CoV-2 experience an altered metabolic state in multiple organs. Metabolic activities are directly involved in modulating immune responses against infectious diseases, yet our understanding of how host metabolism relates to inflammatory responses remains limited. To better elucidate the underlying biochemistry of the leukocyte response, we focused our analysis on possible relationships between SARS-CoV-2 post-infection stages and distinct metabolic pathways. Indeed, we observed a significant altered metabolism of tryptophan and urea cycle pathways in cultures of peripheral blood mononuclear cells obtained 60–90 days after infection and showing in vitro IgG antibody memory for spike-S1 antigen (n = 17). This work, for the first time, identifies metabolic routes in cell metabolism possibly related to later stages of immune defence against SARS-CoV-2 infection, namely, when circulating antibodies may be absent but an antibody memory is present. The results suggest reprogramming of leukocyte metabolism after viral pathogenesis through activation of specific amino acid pathways possibly related to protective immunity against SARS-CoV-2.
ST8SIA6-AS1 contributes to hepatocellular carcinoma progression by targeting miR-142-3p/HMGA1 axis
Authors: Feng Tianhang , Yao Yutong , Luo Le , Zou Haibo , Xiang Guangming , Wei Lingling , Yang Qinyan , Shi Ying , Huang Xiaolun , Lai Chunyou 
Published: January 2023

AbstractHepatocellular carcinoma (LIHC) accounts for 90% of all liver cancers and is a serious health concern worldwide. Long noncoding RNAs (lncRNAs) have been observed to sponge microRNAs (miRNAs) and participate in the biological processes of LIHC. This study aimed to evaluate the role of the ST8SIA6-AS1-miR-142-3p-HMGA1 axis in regulating LIHC progression. RT-qPCR and western blotting were performed to determine the levels of ST8SIA6-AS1, miR-142-3p, and HMGA1 in LIHC. The relationship between ST8SIA6-AS1, miR-142-3p, and HMGA1 was assessed using luciferase assay. The role of the ST8SIA6-AS1-miR-142-3p-HMGA1 axis was evaluated in vitro using LIHC cells. Expression of ST8SIA6-AS1 and HMGA1 was significantly upregulated, whereas that of miR-142-3p was markedly lowered in LIHC specimens and cells. ST8SIA6-AS1 accelerated cell growth, invasion, and migration and suppressed apoptosis in LIHC. Notably, ST8SIA6-AS1 inhibited HMGA1 expression by sponging miR-142-3p in LIHC cells. In conclusion, sponging of miR-142-3p by ST8SIA6-AS1 accelerated the growth of cells while preventing cell apoptosis in LIHC cells, and the inhibitory effect of miR-142-3p was abrogated by elevating HMGA1 expression. The ST8SIA6-AS1-miR-142-3p-HMGA1 axis represents a potential target for the treatment of patients with LIHC.
Heat and mass flux analysis of magneto-free-convection flow of Oldroyd-B fluid through porous layered inclined plate
Authors: Riaz Muhammad Bilal , Ur Rehman Aziz , Wojciechowski Adam , Atangana Abdon 
Published: January 2023

AbstractThe present work examines the analytical solutions of the double duffusive magneto free convective flow of Oldroyd-B fluid model of an inclined plate saturated in a porous media, either fixed or moving oscillated with existence of slanted externally magnetic field. The phenomenon has been expressed in terms of partial differential equations, then transformed the governing equations in non-dimensional form. On the fluid velocity, the influence of different angles that plate make with vertical is studied as well as slanted angles of the electro magnetic lines with the porous layered inclined plate are also discussed, associated with thermal conductivity and constant concentration. For seeking exact solutions in terms of special functions namely Mittag–Leffler functions, G-function etc., for Oldroyd-B fluid velocity, concentration and Oldroyd-B fluid temperature, Laplace integral transformation method is used to solve the non-dimensional model. The contribution of different velocity components are considered as thermal, mass and mechanical, and analyse the impacts of these components on the fluid dynamics. For several physical significance of various fluidic parameters on Oldroyd-B fluid velocity, concentration and Oldroyd-B fluid temperature distributions are demonstrated through various graphs. Furthermore, for being validated the acquired solutions, some limiting models such as Newtonian fluid in the absence of different fluidic parameters. Moreover, the graphical representations of the analytical solutions illustrated the main results of the present work and studied various cases regarding the movement of plate.
Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine
Authors: Shang Linyue , Jin Zhenyu , Wei Huimei , Park Shawn , Zhan Chang-Guo , Zheng Fang 
Published: January 2023

AbstractCocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocaine to pharmacologically inactive metabolite(s) using an efficient cocaine-metabolizing enzyme. Our previous studies have successfully designed and discovered a highly efficient cocaine hydrolase, denoted as CocH5-Fc(M6), capable of rapidly hydrolyzing cocaine at the benzoyl ester moiety. In the present study, we determined the kinetic parameters of CocH5-Fc(M6) against norcocaine (kcat = 9,210 min−1, KM = 20.9 μM, and kcat/KM = 1.87 × 105 min−1 M−1) and benzoylecgonine (kcat = 158 min−1, KM = 286 μM, and kcat/KM = 5.5 × 105 min−1 M−1) for the first time. Further in vivo studies have demonstrated that CocH5-Fc(M6) can effectively accelerate clearance of not only cocaine, but also norcocaine (known as a cocaine metabolite which is more toxic than cocaine itself) and benzoylecgonine (known as an unfavorable long-lasting metabolite with some long-term toxicity concerns) in rats. Due to the desired high catalytic activity against norcocaine, CocH5-Fc(M6) is capable of quickly detoxifying both cocaine and its more toxic metabolite norcocaine after intraperitoneally administering lethal dose of 60 or 180 mg/kg cocaine. In addition, the ability of CocH5-Fc(M6) to accelerate clearance of benzoylecgonine should also be valuable for the use of CocH5-Fc(M6) in treatment of cocaine use disorder.