bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE ROLE OF LEADERSHIP FROM THE PERSPECTIVE OF INTRA ORGANIZATIONAL COMMUNICATIONS AT THE CENTRAL STATISTICS AGENCY OF PALU CITY
Authors: Mariyani Ince , Thahir Harifuddin , Adda Harnida Wahyu 
Published: June 2023

This research aims to find out the role of leadership from the perspective of intra-organizational communication at the Central Statistics Agency of Palu City. This research used a qualitative research method, to find out the facts and phenomena that occur regarding the leadership role from an intra-organizational perspective at the Central Statistics Agency of Palu City. The analysis consists of three stages, namely : data reduction, data presentation, and concluding. The results of the research show that 1) openness, there is a very visible difference in the form of communication carried out by superiors to subordinates (section heads) with employees as the lowest ranks in the organizational level. 2) Empathy, the head of the Central Statistics Agency of Palu City has a high sense of empathy for the problems and work needs of his subordinates, and the situation is not conducive in the environment of the Central Statistics Agency of Palu City. However, for personal interests, the attitude of empathy from the leadership is still lacking. Support, the head of the Central Statistics Agency of Palu City has not fully provided support to subordinates while the support for the fulfillment of facilities and infrastructure is good. 3) Positivity, the work is given by the head of the Central Statistics Agency of Palu City to its employees is responded to with a positive attitude so the positive indicators at the Central Statistics Agency of Palu City are good. 4) Similarity, perception in work which is one of the keys to the success of employees, has been carried out well.
Keywords: Leadership Role, Intra-Organizational Communication
THE INFLUENCE OF WORK DISCIPLINE ON EMPLOYEE COMMITMENT THROUGH WORK CULTURE AT EMPLOYEES OF PT. PLN (PERSERO) CUSTOMER SERVICE IMPLEMENTING UNIT (UP3) PALU
Authors: Pratiwi Munthe Julyandani , Natsir Syahir , Mahardiana Lina 
Published: June 2023

This research aimed to determine the influence of work discipline on organizational commitment through work culture at PT. PLN (Persero) Executive Customer Service Management Unit Palu. This was a correlational research. The research sample was all employees at PT. PLN (PERSERO) Executive Customer Service Management Unit Palu with 154 employees. This research used the Structural Equation Modelling (SEM) method, which is operated by SMART-PLS. The results of this research indicate that 1) Work discipline has a significant influence on employee commitment at PT. PLN (PERSERO) Executive Customer Service Management Unit Palu, 2) Work discipline has a significant influence on work culture at PT. PLN (PERSERO) Executive Customer Service Management Unit Palu, 3) Work culture has a significant influence on employee commitment to PT. PLN (PERSERO) Executive Customer Service Management Unit Palu, 4) Work discipline influence employee commitment mediated by work culture at PT. PLN (PERSERO) Executive Customer Service Management Unit Palu.

Keywords: Work Discipline, Employee Commitment, Work Culture.
ANALYSIS OF OWNERSHIP STRUCTURE INFLUENCE ON COMPANY VALUE IN THE PROPERTY AND REAL ESTATE INDUSTRY ON THE INDONESIA STOCK EXCHANGE
Authors: Akbar Muhammad , Muslimin Muslimin , Kasim Muhammad Yunus 
Published: June 2023

This research aims at determining the influence of ownership structure on company value of property and real estate industry on the Indonesia Stock Exchange. This research was quantitative research using panel data regression analysis. The object of this research was property and real estate companies listed on Indonesia Stock Exchange in 2010-2019. The results indicate that the ownership structure consisting of managerial ownership, institutional ownership, and foreign ownership together have a significant influence on company value. Managerial ownership partially has no effect on company value. Partial institutional ownership has a significant negative influence on company value. Partial foreign ownership has no influence on company value.

Keywords: Managerial Ownership, Institutional Ownership, Foreign Ownership, Company Value.
PREVENTING GOODS/SERVICES PROCUREMENT FRAUD IN HANDLING COVID-19 AND ITS IMPLICATION ON FINANCIAL PERFORMANCE IN SIGI DISTRICT
Authors: Sustrianti Sustrianti , Miru Sulaeman , Kadang Juliana 
Published: June 2023

This research aimed to determine: 1) The influence of the internal control system on preventing goods/services procurement fraud in handling covid-19 in Sigi District, 2) The influence of compensation suitability on preventing goods/services procurement fraud in handling covid-19 in Sigi District, 3) The influence of organizational commitment to the prevention of goods/services procurement fraud in handling covid-19 in Sigi District, 4) The influence of the internal control system on the financial performance of Sigi District, 5) The influence of compensation suitability on the financial performance of Sigi District, 6) The influence of organizational commitment on the financial performance of Sigi District, 7) The influence of preventing goods/services procurement fraud in handling COVID-19 on the financial performance of Sigi District. Type of the research was quantitative approach with a sample of 30 respondents. Data analysis technique used path analysis with purposive sampling technique. The results of the research indicate that the internal control system has a positive and insignificant influence on preventing goods/services procurement fraud in handling covid-19 in Sigi District; the suitability of compensation has a positive and significant influence on preventing goods/services procurement fraud in handling covid-19 in Sigi District; organizational commitment has a positive and insignificant influence on preventing goods/services procurement fraud in handling covid-19 in Sigi District; the internal control system has a positive and significant influence on the financial performance of Sigi District; compensation suitability has a positive and significant influence on the financial performance of Sigi District; organizational commitment has a positive and significant influence on the financial performance of Sigi District and the prevention of goods/services procurement fraud in handling COVID-19 has a positive and insignificant influence on the financial performance of Sigi District.

Keywords: Internal Control System, Compensation Suitability, Organizational Commitment, Fraud Prevention, Financial Performance.
MFAP2 enhances cisplatin resistance in gastric cancer cells by regulating autophagy
Authors: Li Meng , Zhang Hong-Yi , Zhang Rong-Gui 
Published: June 2023

Background
Cisplatin (CDDP) is of importance in cancer treatment and widely used in advanced gastric cancer (GC). However, its clinical usage is limited due to its resistance, and the regulatory mechanism of CDDP resistance in GC has not yet been fully elucidated. In this study, we first conducted a comprehensive study to investigate the role of MFAP2 through bioinformatics analysis.

Methods
The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were applied to downloadgene expression data and clinicopathologic data, and the differentially expressed genes (DEGs) were further analyzed. Then, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis and survival analysis were conducted. Furthermore, according to the clinicopathological characteristics of TCGA, clinical correlation analysis was conducted, and a receiver operating characteristic curve (ROC) was plotted.

Results
We revealed that FAP, INHBA and MFAP2 were good diagnostic factors of GC. However, the mechanism of MFAP2 in GC remains elusive, especially in the aspect of chemotherapy resistance. We developed the CDDP-resistant cell line, and found that MFAP2 was upregulated in CDDP-resistant cells, and MFAP2-knockdown improved CDDP sensitivity. Finally, we found that MFAP2 enhanced CDDP resistance by inducing autophagy in drug-resistant cell lines.

Conclusions
The above results suggested that MFAP2 could affect the chemotherapy resistance by altering the level of autophagy in GC patients as a potential therapeutic target.
Evaluation of Glycemic Index, Hypolipidemic and Hypoglycemic Activities of “osu une” on Alloxan Induced Diabetic Rats
Authors: Umerah N. N. , Asouzu A. I. 
Published: June 2023

Background: The incidence of diabetes has been on the increase due to increase in sedentary lifestyle together with increase in life expectancy. “Osu une” is a native meal in Anambra State, Nigeria used in the management of diabetics. There is no scientific based study/data to ascertain the effect on blood glucose level.
Objective: The study investigated the glycemic index, hypolipidemic and hypoglycemic activities of “osu une” on Alloxan induced rats.
Methods: The “osu une” was prepared, dried and blended. Twenty adult male Albino rats were grouped into four of five rats each based on their body weight. Alloxan at a dose of 42mg/kg was induced intravenously through tails of group 2-4 rats. Blood samples were collected from the ocular vein and analyzed for blood glucose and lipid profile on day 7, 14 and 28 using standard method. Ten healthy subjects aged between 24 -40 participated in this study. They were fed with the standard food (50 g glucose) on day one and the test foods on day two, after an overnight fast. Blood samples were taken at 0, 30, 60, 120, and 180 min after the food had been eaten.
Results: The result showed that rats that received ‘osu une’ extract showed an increase in body weight from 130.70mg/kg to 146.20mg/kg, while rats that received glucophage tablets also showed an increase in body weight from 126.01mg/kg to 158.81mg/kg after inducing diabetes. The rats fed ‘osu une’ extract had a decrease in fasting blood glucose level, total cholesterol (TC), triglycerides, Low Density Lipoprotein (LDLc) and increase in High Density Lipoprotein (HDLc). The test diet had a low glycemic index of 9.59.
Conclusion: The study shows that “osu une” can play a key role in the management of Diabetes Mellitus.
Evaluation of Different Aphrodisiac Therapy Effect by Using Some Biochemical Parameters in Female Wistar Albino Rats
Authors: Aminu Fatima , Abubakar Farida Suleiman , Muhammad Bawa Yusuf , Nweze C. C. , Bamidele T. O. , Audu S. S. , Zaruwa M. Z. 
Published: June 2023

Since ancient times, humans across diverse tradition, cultures and religious background have shown keen interest in traditional herbal products which enhance sexual ability, pleasure and libido as well as improving sexual functions and potency. The use of herbal aphrodisiacs among men and women in Nigeria is on the high side.
This research aimed to study the effect of Mi jian fen (MJF) (a foreign aphrodisiac) and Tsumin marke (TM) (a local aphrodisiac) on female libido. The research also aimed at determining the possible effects of MJF and TM on some toxicological parameters.
Eighteen Female wistar albino rats were selected randomly and assigned into six groups of three animals each. Group A served as the control group. Group B served as the standard rats in this group were given 0.2mg/kg dose of Clomid. Groups C and D were given low (0.2mg/kg) and high (0.4mg/kg) doses of MJF respectively. Groups E and F were given low (0.2mg/kg) and high (0.4mg/kg) doses of TM, respectively. All treatments were administered for a period of thirty days after which rats were sacrificed and blood samples collected. FSH, LH, Estrogen, ALT, AST, ALP, Urea, Creatinine and Hematological parameters were assayed using standard methods.
At the end of the analysis, it was observed that the levels of LH increased significantly (p<0.05) in all the groups that were treated with high and low doses of MJF and TM, likewise FSH and estrogen. AST and ALT were slightly increased in all test groups while ALP was increased significantly (p<0.05) in all test groups. Urea increased significantly (p<0.05) in all test groups while creatinine increased slightly in all test groups.
The results obtained confirmed MJF and TM to be potent aphrodisiacs. However, MJF shows to be a bit more libido enhancer them TM. The toxicity of MJF on the liver and kidney of the animals seem to be higher compared to that of TM. It is then concluded that long term usage of these substances could lead to clinical complications among human users.
Evaluate the Correlation and Regression Studies of Growth, Yield Attributes and Yield of Transplanted Finger Millet (Eleusine coracana L. Gaertn) under Different Weed Management
Authors: Chetty M. Rinky , Kumar K. Udhaya , Silambarasan M. , Lekha S. J. Blessy 
Published: June 2023

Aim: To evaluate the “Correlation and Regression Studies of Growth, Yield Attributes and Yield of finger millet under different weed management.”
Study Design: Randomized Complete Block Design (RBD).
Place and Duration of Study: The field trial was conducted during the Rabi season of 2021-22 at Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu. The experimental field had a silky clay loam soil composition.
Methodology: The field trial comprised of eight treatments and was replicated three times. In the experimental farm, the variety Paiyur 2 was grown into nursery and transplanted at 25th day with the spacing of 30 × 15 cm and followed the all other agronomic practices. To experimented the following treatments viz., T1- PE of pretilachlor at 1.0 kg ha-1,T2- PE of pretilachlor at 0.75 kg ha-1+ one hand weeding on 35th DAT, T3- PE of pendimethalin at 0.5 kg ha-1,T4- PE of pendimethalin at 0.5 kg ha-1+ one hand weeding on 35th DATP, T5- PE of Butachlor at 1.0 kg ha-1,T6- PE of Butachlor at 0.75 kg ha-1+ one hand weeding on 35th DAT, T7- POE of 2,4-D at 2 kg ha-1on 35 th DAT, T8- POE of 2,4-D at 2 kg ha-1+ one hand weeding on 35th DAT, T9- Two hand weeding at 35 DAT and 70 DAT, T10- Unweeded check. The biometric observations were recorded at three specific time points: 35 DAT, 70 DAT, and at harvest stage.
Results: The grain yield was highly significant positive correlation with Straw yield (r = 0.893), Leaf area index (r =0.975), Dry matter accumulation at 70 DAT (r=0.966), Dry matter accumulation at harvest (r =0.966), Productive tillers (r =0.902), Test weight (r =0.903), Weed control efficiency (r =0.797), Nitrogen uptake (r =0.980), Phosphorus uptake (r =0.972), Potassium uptake (r =0.960). However, significant positive correlation with Plant height (r =0.733). From the regression every unit increase in stover yield, plant height, LAI at 70 DAT, crop dry matter at 70 DAT, crop dry matter at harvest, number of productive tillers plant-1, test weight, Weed Control Efficiency and N, P and K uptake by crop substantially increased the grain yield by 0.798, 0.537, 0.951, 0.932, 0.992, 0.812, 0.865, 0.635, 0.960, 0.944 and 0.920 kg ha-1 respectively.
POLY4 Positively Improves the Growth, Fodder Yield and Quality of Oat (Avena sativa L.) in Semi-Arid Tropics of Central India
Authors: Ola Shrawan Kumar , Prasad Mahendra , Choudhary Mukesh , Srinivasan R. , Singh Susheel Kumar , Kumar Anup , Palsaniya Dana Ram , Kumar Sunil 
Published: June 2023

A study was carried out to examine the effects of different potassium fertilizer sources on growth, fodder yield and quality at the Research Farm, Rani Lakshmi Bai Central Agricultural University, Jhansi, Uttar Pradesh. The experiment was conducted under semi-arid climatic conditions in a simple Randomized Block Design (RBD) with ten treatments (control, 100% NP, 100% recommended dose of potassium (RDK) through MOP, 100% RDK through SOP, 100% RDK through POLY4, 75% RDK+ 1% RDK foliar spray (30 days after sowing and 30 days after fodder harvest) through POLY4, 100% RDK through schoenite and 75% RDK+ 1% RDK foliar spray (30 days after sowing and 30 days after fodder harvest) through schoenite, 75% RDK through MOP + KSB (potassium solubilizer bacteria, Seed treatment), KSB alone (Seed treatment) and three replications. Results showed that application of 75% RDK+ 1% RDK foliar spray (30 days after sowing and 30 days after fodder harvest) through POLY4 recorded the significantly highest growth and yield contributing parameters, which is beneficially resulted in increased green fodder yield (159%) as compared to control. However, it was at par with the application 75% RDK+ 1% RDK foliar spray (30 days after sowing and 30 days after fodder harvest) through schoenite. The fodder quality parameters viz. CP, ADF, and NDF were also remarkably improved with the application of 75% RDK+1% RDK foliar spray (30 days after sowing and 30 days after fodder harvest) through POLY4 in oat crop. The results imply that farmers may apply 75% RDK+1% RDK foliar spray through POLY4 to achieve good quality higher green fodder in sandy clay loam soil for oat production.
Effect of Exogenous Albumin Replacement on Plasma Colloid Osmotic Pressure in Severe Preeclampsia: A Case-control Study
Authors: Vázquez-Rodríguez Juan Gustavo , Vázquez-Arredondo Juan Gustavo , Cruz-Martínez Francisco Javier 
Published: June 2023

Background: In preeclampsia, hypoalbuminemia reduces plasma colloid osmotic pressure (PCOP) and favors capillary leakage. Replacement with exogenous albumin is a therapeutic alternative.
Objective: to determine the effect of exogenous albumin replacement on PCOP in patients with severe preeclampsia (SP).
Methods: A case-control study was carried out in 76 pregnant patients with SP from the Intensive Care Unit (ICU). The case group (n=38) received 0.9% saline solution 1000 ml every 8 hours and 25% albumin 50 ml every 8 hours and the control group (n=38) only received 0.9% saline solution 1000 ml every 8 hours. Plasma albumin concentrations, PCOP, hemodynamic and laboratory data from admission (baseline measurement) vs discharge from the ICU (final measurement) of both groups were compared.
Statistical Analysis: the data was analyzed with descriptive statistics, paired Student's t-test and Pearson's correlation coefficient with the statistical program SPSS® version 20. The p value <0.05 was significant.
Results: A significant decrease in plasma albumin was found (case group 2.72±0.44 vs 2.45±0.48 g/dL, p=0.0141; control group 3.06±0.33 vs 2.58±0.29 g/dL, p=0.0431). PCOP was also significantly reduced (case group 18.44±2.92 vs 16.82±2.70 mmHg, p=0.0210; control group 20.38±2.28 vs 17.46±1.96 mmHg, p=0.0763). The group of cases showed an increase in uresis (p=0.0326), but without changes in central venous pressure (p=0.3246) and serum creatinine (p=0.9515). With this evidence the recommendation is that its use in patients with preeclampsia should be reserved for the experience of the medical team.
Conclusion: Exogenous albumin replacement therapy did not correct the PCOP values or the blood albumin concentration.
Association Between Duration of Immunotherapy and Overall Survival in Advanced Non–Small Cell Lung Cancer
Authors: Sun Lova , Bleiberg Benjamin , Hwang Wei-Ting , Marmarelis Melina E. , Langer Corey J. , Singh Aditi , Cohen Roger B. , Mamtani Ronac , Aggarwal Charu 
Published: June 2023

ImportanceFor patients with advanced non–small cell lung cancer (NSCLC) treated with frontline immunotherapy-based treatment, the optimal duration of immune checkpoint inhibitor (ICI) treatment is unknown.ObjectiveTo assess practice patterns surrounding ICI treatment discontinuation at 2 years and to evaluate the association of duration of therapy with overall survival in patients who received fixed-duration ICI therapy for 2 years vs those who continued therapy beyond 2 years.Design, Setting, and ParticipantsThis retrospective, population-based cohort study included adult patients in a clinical database diagnosed with advanced NSCLC from 2016 to 2020, who received frontline immunotherapy-based treatment. The data cutoff was August 31, 2022; data analysis was conducted from October 2022 to January 2023.ExposuresTreatment discontinuation at 2 years (between 700 and 760 days, fixed duration) vs continued treatment beyond 2 years (greater than 760 days, indefinite duration).Main Outcomes and MeasuresOverall survival from 760 days was analyzed using Kaplan-Meier methods. Multivariable Cox regression that adjusted for patient-specific and cancer-specific factors was used to compare survival beyond 760 days between the fixed-duration group and the indefinite-duration group.ResultsOf 1091 patients in the analytic cohort who were still on ICI treatment at 2 years after exclusion criteria for death and progression were applied, 113 patients (median [IQR] age, 69 [62-75] years; 62 [54.9%] female; 86 [76.1%] White) were in the fixed-duration group, and 593 patients (median [IQR] age, 69 [62-76] years; 282 [47.6%] female; 414 [69.8%] White) were in the indefinite-duration group. Patients in the fixed-duration group were more likely to have a history of smoking (99% vs 93%; P = .01) and be treated at an academic center (22% vs 11%; P = .001). Two-year overall survival from 760 days was 79% (95% CI, 66%-87%) in the fixed-duration group and 81% (95% CI, 77%-85%) in the indefinite-duration group. There was no statistically significant difference in overall survival between patients in the fixed-duration and indefinite-duration groups, either on univariate (hazard ratio [HR] 1.26; 95% CI, 0.77-2.08; P = .36) or multivariable (HR 1.33; 95% CI, 0.78-2.25; P = .29) Cox regression. Approximately 1 in 5 patients discontinued immunotherapy at 2 years in the absence of progression.Conclusions and RelevanceIn a retrospective clinical cohort of patients with advanced NSCLC who were treated with immunotherapy and were progression-free at 2 years, approximately only 1 in 5 discontinued treatment. The lack of statistically significant overall survival advantage for the indefinite-duration cohort on adjusted analysis provides reassurance to patients and clinicians who wish to discontinue immunotherapy at 2 years.
Defect Engineering in Biomedical Sciences
Authors: Yuan Meng , Kermanian Mehraneh , Agarwal Tarun , Yang Zhuang , Yousefiasl Satar , Cheng Ziyong , Ma Ping'an , Lin Jun , Maleki Aziz 
Published: June 2023

AbstractWith the promotion of nanochemistry research, large numbers of nanomaterials have been applied in vivo to produce desirable cytotoxic substances in response to endogenous or exogenous stimuli for achieving disease‐specific therapy. However, the performance of nanomaterials is a critical issue that is difficult to improve and optimize under biological conditions. Defect‐engineered nanoparticles have become the most researched hot materials in biomedical applications recently due to their excellent physicochemical properties, such as optical properties and redox reaction capabilities. Importantly, the properties of nanomaterials can be easily adjusted by regulating the type and concentration of defects in the nanoparticles without requiring other complex designs. Therefore, this tutorial review focuses on biomedical defect engineering and briefly discusses defect classification, introduction strategies, and characterization techniques. Several representative defective nanomaterials are especially discussed in order to reveal the relationship between defects and properties. A series of disease treatment strategies based on defective engineered nanomaterials are summarized. By summarizing the design and application of defective engineered nanomaterials, a simple but effective methodology is provided for researchers to design and improve the therapeutic effects of nanomaterial‐based therapeutic platforms from a materials science perspective.