bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital health programme following rhythm control in patients with atrial fibrillation: comprehensive disease management by self-monitoring, coaching, and telemedicine
Authors: von Degenfeld Georges , Langbein Anke , Boscheri Alessandra , Ziegler Maximilian O , Demlehner Jonas , Weyh Paul , Leber Alexander , Schreier Sandra , Spitzer Stefan G 
Published: January 2025

Abstract

Aims
Digital health is becoming increasingly powerful and available but is frequently not effectively integrated into daily practice. A hybrid programme was developed to provide holistic diagnostic and therapeutic patient care in atrial fibrillation.

Methods and results
Patients (n = 68) were recruited at the electrophysiology centre following successful interventional restoration of sinus rhythm. The 12-month programme consists of the key modalities: (i) self-recording of one-lead electrocardiograms (ECGs), (ii) short-term remote ECG diagnosis and medical advice by video consultation, and (iii) App-based education on lifestyle and risk factor optimization with video consultation. Patients recorded 29 092 ECGs, averaging 1.42 ECGs/day. Recurrent arrhythmia was found and confirmed in 39 patients. In all cases, arrhythmia was first diagnosed based on wearable ECG over the platform, rather than by standard in-office ECG/Holter. No false positive occurred. Patients with recurred arrhythmia were treated by pulmonary vein isolation (n = 17), electric cardioversion (n = 17), antiarrhythmic medication (n = 5), or other interventional procedures (n = 1). Most patients (n = 30) scheduled a video consultation over the App as the first medical touchpoint after arrhythmia occurrence. In 21 patients with arterial hypertension, systolic blood pressure was reduced by 8.0 ± 8.6 mmHg (mean ± SD), P &lt; 0.01. In 25 patients with obesity (body mass index ≥ 30), body weight was reduced by 3.6 ± 5.5 kg (mean ± SD), P &lt; 0.01.

Conclusion
This real-world analysis indicates that the hybrid holistic programme is applicable in daily practice and is actively followed by patients and improves diagnostic and therapeutic outcomes. These promising data need to be confirmed in a controlled randomized study.
Bentham, O’Connell and the Failure of Radical Politics of Law Reform, 1828–1831
Authors: Li Cheng 
Published: January 2025

Abstract
This article examines the efforts of Jeremy Bentham to ally himself with the Irish Catholic leader Daniel O’Connell for the purpose of radical law reform. Between October 1828 and October 1829, Bentham provided three petitions to O’Connell to collect signatures and raise public support in Ireland for legal codification, judicial reforms and an Equity Dispatch Court. O’Connell responded with different levels of enthusiasm, and after July 1830 he was no longer passionate about promoting codification. Meanwhile, Bentham complained privately that O’Connell had been corrupted by the Whigs. It is argued that O’Connell’s public alliance with Bentham should be understood in the context of his personal negotiations with both Whigs and Tories. O’Connell’s support for Bentham was heavily influenced by practical considerations, such as the need to increase his bargaining power for the Irish interest. On the other hand, Bentham developed unrealistic expectations about O’Connell’s commitment to his law reform petitions. It is argued that the alliance between O’Connell and Bentham was mostly tactical, and that its eventual dislocation was the result of conflicting reform priorities and political strategies.
Composition, source appointment, and biomigration of per- and polyfluoroalkyl substances in the Fu River of Wuhan, China
Authors: Shi Si , Zhang Zijie , Wang Rong , Xue Shiji , Fei Wanyu , Peng Yue’e 
Published: January 2025

Abstract
In this study, a detailed analysis of 20 per- and polyfluoroalkyl substances (PFAS) was conducted, in different environmental media of the Fu River, the main sewage storage body, located near the Tianhe Airport in Wuhan, China. The PFAS included 13 perfluorocarboxylic acids (C4–C18), four perfluorosulfonic acids (C4, C6, C8, C10), and three PFAS. In the surface water samples, short-chain PFAS perfluorobutanesulfonic acid (PFBS) and perfluorobutanoic acid were the most prevalent and highest concentrations, 168 ng/L and 49.7 ng/L, respectively. However, in the sediment samples, PFBS and perfluorooctane sulfonate (PFOS) were the most prevalent and highest concentrations, 840 ng/kg and 1,510 ng/kg, respectively. In addition, PFOS was the most prevalent substance, with the highest concentrations measured at 23.3 μg/kg in egg yolk and 28.1 μg/kg in fish, accounting for proportions of 82% and 88%, respectively. Two new short-chain substitutes of PFOS, 6:2 clorinated polyfluoroalykyl ether sulfonate and 8:2 clorinated polyfluoroalykyl ether sulfonate, emerged in sediment and fish. The PFAS in eggs, fish, and vegetables of the Fu River Basin poses a potential health risk to residents according to the suggested values of the European Food Safety Agency.
Transcriptomic Data Reveal Divergent Paths of Chitinase Evolution Underlying Dietary Convergence in Anteaters and Pangolins
Authors: Allio Rémi , Teullet Sophie , Lutgen Dave , Magdeleine Amandine , Koual Rachid , Tilak Marie-Ka , de Thoisy Benoit , Emerling Christopher A , Lefébure Tristan , Delsuc Frédéric 
Published: January 2025

Abstract
Ant-eating mammals represent a textbook example of convergent evolution. Among them, anteaters and pangolins exhibit the most extreme convergent phenotypes with complete tooth loss, elongated skulls, protruding tongues, and hypertrophied salivary glands producing large amounts of saliva. However, comparative genomic analyses have shown that anteaters and pangolins differ in their chitinase acidic gene (CHIA) repertoires, which potentially degrade the chitinous exoskeletons of ingested ants and termites. While the southern tamandua (Tamandua tetradactyla) harbors four functional CHIA paralogs (CHIA1-4), Asian pangolins (Manis spp.) have only one functional paralog (CHIA5). Here, we performed a comparative transcriptomic analysis of salivary glands in 33 placental species, including 16 novel transcriptomes from ant-eating species and close relatives. Our results suggest that salivary glands play an important role in adaptation to an insect-based diet, as expression of different CHIA paralogs is observed in insectivorous species. Furthermore, convergently evolved pangolins and anteaters express different chitinases in their digestive tracts. In the Malayan pangolin, CHIA5 is overexpressed in all major digestive organs, whereas in the southern tamandua, all four functional paralogs are expressed, at very high levels for CHIA1 and CHIA2 in the pancreas and for CHIA3 and CHIA4 in the salivary glands, stomach, liver, and pancreas. Overall, our results demonstrate that divergent molecular mechanisms within the chitinase acidic gene family underlie convergent adaptation to the ant-eating diet in pangolins and anteaters. This study highlights the role of historical contingency and molecular tinkering of the chitin digestive enzyme toolkit in this classic example of convergent evolution.
Horizontal Transfer and Recombination Fuel Ty4 Retrotransposon Evolution in Saccharomyces
Authors: Chen Jingxuan , Garfinkel David J , Bergman Casey M 
Published: January 2025

Abstract
Horizontal transposon transfer (HTT) plays an important role in the evolution of eukaryotic genomes; however, the detailed evolutionary history and impact of most HTT events remain to be elucidated. To better understand the process of HTT in closely related microbial eukaryotes, we studied Ty4 retrotransposon subfamily content and sequence evolution across the genus Saccharomyces using short- and long-read whole genome sequence data, including new PacBio genome assemblies for two Saccharomyces mikatae strains. We find evidence for multiple independent HTT events introducing the Tsu4 subfamily into specific lineages of Saccharomyces paradoxus, Saccharomyces cerevisiae, Saccharomyces eubayanus, Saccharomyces kudriavzevii and the ancestor of the S. mikatae/Saccharomyces jurei species pair. In both S. mikatae and S. kudriavzevii, we identified novel Ty4 clades that were independently generated through recombination between resident and horizontally transferred subfamilies. Our results reveal that recurrent HTT and lineage-specific extinction events lead to a complex pattern of Ty4 subfamily content across the genus Saccharomyces. Moreover, our results demonstrate how HTT can lead to coexistence of related retrotransposon subfamilies in the same genome that can fuel evolution of new retrotransposon clades via recombination.
Analysis of different strains of the turquoise killifish identify transcriptomic signatures associated with heritable lifespan differences
Authors: Mazzetto Mariateresa , Reichwald Kathrin , Koch Philipp , Groth Marco , Cellerino Alessandro 
Published: January 2025

Abstract
The African turquoise killifish Nothobranchius furzeri represents an emerging short-lived model for aging research. Captive strains of this species are characterized by large differences in lifespan. To identify the gene expression correlates of this lifespan differences, we analyzed a public transcriptomic dataset consisting of four different tissues in addition to embryos. We focused on the GRZ and the MZM0410 captive strains, which show a near twofold difference in lifespan, but similar growth and maturation and validated the results in a newly-generated dataset from a third longer-lived strain. The two strains show distinct transcriptome expression patterns already as embryos and the genotype has a larger effect than age on gene expression, both in terms of number of differentially expressed genes and magnitude of regulation. Network analysis detected RNA processing and histone modifications as the most prominent categories upregulated in GRZ that also showed idiosyncratic expression patterns such as high expression of DND is somatic tissues. The short-lived GRZ strain shows transcriptional aging signatures already at sexual maturity (anticipated aging) in all four tissues suggesting that short lifespan is the results of events that occur early in life rather than the progressive accumulation of strain-dependent differences. The GRZ strain is the most commonly used N. furzeri strain in intervention studies and our results warrant replication of at least key intervention studies in longer-lived strains.
Better mental health and fewer depressive symptoms are associated with greater psychological resilience after hip fracture
Authors: McClennen Taylor , Sharma Hari , Kiel Douglas P , Fortinsky Richard H , Guild Camelia P , Orwig Denise , Magaziner Jay , Binder Ellen F , Berry Sarah D 
Published: January 2025

Abstract

Background
High psychological resilience is associated with improved functional outcomes for older adults recovering from hip fracture. The objective of this study was to identify factors associated with increased psychological resilience in older women after hip fracture.

Methods
129 women aged ≥65 years with recent surgically-repaired hip fracture were enrolled in a trial of exercise and testosterone therapy. The Brief Resilience Scale (BRS) measured baseline resilience, and was categorized as low (BRS&lt;4) or high (BRS≥4). Sociodemographic (e.g., education), medical, and neuropsychological factors (e.g., cognition by Short Blessed Test, mental health by a Global Mental Health Score (PROMIS-GMH), and depressive symptoms by Geriatric Depression Score (GDS)) were considered as independent variables. Individual factors were evaluated for their association with resilience using bivariate regression, and those having a significance level of p≤0.10 were entered into age-adjusted multivariate logistic regression models.

Results
57 women (44%) reported high resilience. Neither education nor cognition was significantly associated with resilience. Lower GDS and better PROMIS-GMH scores were associated with high resilience in adjusted models. For every one-point worsening in GDS, the adjusted odds ratio (AOR) for high vs. low resilience was 0.76 (95% CI 0.61,0.93). In a model with GDS, PROMIS-GMH, and age, positive mental health remained significantly associated with higher resilience (AOR 1.34, 95% CI 1.14,1.58).

Conclusions
In older women after hip fracture, fewer depressive symptoms and better mental health were associated with higher psychological resilience. Addressing overall mental health when recovering from hip fracture could contribute to increasing psychological resilience thereby maximizing recovery potential.
Wound Healing After Vaginal Delivery, Episiotomy, and Cesarean Section Delivery Among Women With IBD: Results From the PIANO Registry
Authors: Lewin Sara , Long Millie , Cohen Russell , Scherl Ellen , Wolf Douglas , Mahadevan Uma 
Published: January 2025

Abstract

Background
Women with inflammatory bowel disease (IBD) face complexities of disease management during pregnancy and childbirth. Apprehension regarding vaginal delivery in pregnant individuals with IBD persists due to concern for perianal disease and perineal trauma. The incidence of poor wound healing after obstetric anal sphincter injury is approximately 4% in the general population. In an IBD population, risk of developing and difficulty healing perineal tears and episiotomy is not well described.

Methods
In a multicenter prospective cohort of pregnant individuals with IBD, we collected demographic information, IBD disease and treatment history, pregnancy and labor history, and reports of delayed wound healing &gt;1 month from episiotomy, vaginal tear, or Cesarean (C-) section. Prospective data were collected using questionnaires that were administered each trimester of pregnancy, at delivery, and in the year postpartum.

Results
There were 743 patients in the PIANO registry who answered questions pertaining to postpartum wound healing, with 330 (44%) reporting a C-section and 413 (56%) reporting a vaginal delivery. Of 119 C-section deliveries assessed for delayed wound healing, only 1 (0.8%) patient reported this complication. Episiotomies were reported in 59 (14%) patients, with 9 (15%) reporting delayed wound healing. Vaginal tears were reported in 252 (64%) patients. Delayed wound healing from vaginal tear was reported in 9% of patients. Use of immunomodulators was associated with delayed wound healing from episiotomy (33% vs 0% for those on no medications, P = .024). No difference was seen in wound healing time for episiotomy with other medications, including corticosteroids, anti-tumor necrosis factor, or anti-integrin use. Delayed wound healing from vaginal tear was not associated with any class of IBD medication.

Conclusions
Episiotomy was a common occurrence in patients with IBD. Immunomodulator, but not biologic, use was found to be associated with delayed wound healing. This association could reflect a direct medication effect on episiotomy wound healing or inadequate treatment of underlying active disease prior to delivery. Vaginal tears were also common but delayed wound healing was not associated with IBD therapy. C-section occurred at high rates, particularly in Crohn’s disease patients, with no reported delays in postpartum wound healing.
Application of wide-field electromagnetic method for skarn-type polymetallic deposits exploration in the Yemaquan, Qinghai Province, China
Authors: Wang Jinhai , Pan Tong , Li Diquan , Zhang Heng , Zhan Jun 
Published: January 2025

Abstract
The Qimantag region in the East Kunlun Mountains is a significant skarn-type polymetallic metallogenic belt in China. With the exhaustion of shallow deposits due to extensive geological and exploration work, there is a pressing need to explore deeper buried ore bodies. The desert soil cover limits the effectiveness of geological and geochemical surveys. Traditional magnetic and gravity surveys have been the primary methods for early exploration but are inadequate for deep exploration. This study applies the Wide-field Electromagnetic Method (WFEM) to mineral exploration in the Yemaquan area of Qimantag region. Developed from the Controlled Source Audio-frequency Magnetotellurics (CSAMT), WFEM uses a vertical or horizontal dipole source to generate electromagnetic responses. It calculates apparent resistivity from a single observed parameter, significantly reducing data acquisition costs. The method is especially effective for identifying deep metal deposits under thick cover. WFEM data were recorded and then processed using the Gauss-Newton method for 2D inversion, followed by 3D kriging interpolation to generate a resistivity model at a depth of 1000 meters in the study area. The results revealed the distribution and contact relationships of sedimentary strata and rock bodies, correlating well with existing geological and geophysical data. Drilling verified the presence of iron, copper, and other polymetallic ore bodies, demonstrating the potential of WFEM for mineral exploration in areas with weak magnetic anomalies. This study validates the effectiveness of WFEM in detecting deep polymetallic deposits in the Qimantag area and provides valuable reference for future exploration in similar geological environments.
Colonic herniation through the foramen of Winslow—to close the defect or not?
Authors: Gitlin Saige , Hakmi Hazim , Pyke Owen , Brathwaite Collin E , Levine Jun , Kella Venkata 
Published: January 2025

Abstract
Internal herniation through the foramen of Winslow (FoW) is a rare, life-threatening diagnosis. We present a case of intestinal obstruction due to herniation of the ileum, cecum, appendix, and ascending colon through the FoW. We reduced the herniation using a small colotomy and preserved the entirety of the bowel. We closed the FoW and colotomy and secured the bowel to the lateral abdominal wall by suture cecopexy. Due to the rarity of this pathology, the literature remains unclear about the benefits of prophylactic measures, hence, we recommend continued reporting of cases and research on prophylactic measures. Further, our own treatment strategy outlined in this report may provide further insight into the misdiagnosis and management of FoW hernias.
Ruptured distal anterior cerebral artery aneurysm presenting with acute subdural hematoma without subarachnoid hemorrhage
Authors: Yamazaki Michio , Aoki Taisei , Matano Fumihiro , Murai Yasuo 
Published: January 2025

Abstract
We report a case of distal anterior cerebral artery (DACA) aneurysm presenting with subdural hematoma (SDH) without subarachnoid hemorrhage (SAH). A patient in his fifties presented with headache. Fluid-attenuated inversion recovery magnetic resonance imaging revealed SDH in the interhemispheric fissure and left frontotemporal region. SAH was not detected. Computed tomographic angiography revealed aneurysms in the left internal carotid artery (ICA) and DACA. The patient underwent frontotemporal craniotomy, which confirmed an unruptured ICA aneurysm, followed by bilateral frontal craniotomy for clipping of DACA aneurysm. The left DACA aneurysm was identified as the source of the SDH. Intraoperative findings showed adhesion between the aneurysm body and falx cerebri, explaining the SDH formation. Literature review identified only six reported cases of SDH without SAH due to DACA aneurysm. Evidence suggests that DACA aneurysms have a relatively higher propensity to cause SDH without SAH, likely due to the anatomical characteristics of the parent vessel and aneurysm projection.
Lumbosacral posterior meningocele in adult patient: a case report
Authors: Wahid Ali Tarik Abdul , Abdulghani Zahraa Monjed , Al-Fatlawi Nabeel , Al-Badri Sajjad Ghanim 
Published: January 2025

Abstract
Spinal dysraphism is the incomplete fusion of the neural arch, which can be seen as an occult or open neural tube defect. Meningoceles are a form of open neural tube defect characterized by cystic dilatation of the meninges containing cerebrospinal fluid without the involvement of neural tissue. Neurosurgical intervention is necessary in the newborn period since survival in advancing ages is often impossible. Therefore, meningoceles are rarely reported in adulthood. Here, we discussed a case of a 23-year-old female who presented with a meningocele in the lumbosacral area since birth, which had not been operated on. Surgical management and intraoperative findings are also discussed.
The effect of rice and edible starch compound ratios, starch type, and rice nutrients on Burkholderia gladioli pathovar cocovenenans growth and bongkrekic acid production in wet rice noodles and starch products
Authors: Huang Jingmin , Huang Jianfei , Liu Xiaoqing , Li Leshi , Lin Zeyu , Liu Xiaole , Lai Xintian , Kang Lirong , Liao Jingru , Chen Jing 
Published: January 2025

Abstract
Bongkrekic acid (BA) toxin, produced by Burkholderia gladioli pathovar cocovenenans bacteria, has been implicated in foodborne illness outbreaks. BA poisoning is associated with rice noodle consumption; hence, this study investigated B. cocovenenans growth and BA production in wet rice noodles comprising varying starch ratios, starch types, rice nutrients, and saccharides. Noodles with 100% rice flour had BA concentrations 47.7 times higher than that of 100% starch samples (30.53 ± 1.08 mg∙kg−1 vs 0.65 ± 0.03 mg∙kg−1). Moreover, protein powder and glucose significantly promoted BA production (P &lt; 0.05). Corn starch with 120 μl∙100 ml−1 rice oil had a BA concentration of 0.23 ± 0.01 mg∙kg−1, which was 31% lower than those without rice oil. Acid-treated starch had a BA concentration 7.24 times higher than that of other natural starch and no BA was detected in acetate starch. Of the carbohydrates tested, only hexacarbon sugars stimulated BA production. Overall, the degree of carbohydrate hydrolysis critically influenced BA formation. Increasing the use of edible starch and reducing the amount of polysaccharides hydrolyzed into monosaccharides during production will mitigate the risk of B. cocovenenans-related food poisoning in rice noodles and starch products. Rice oil serves as a possible additive to hinder BA production.
Constraining γ-ray dissipation site in gravitationally lensed quasar – PKS 1830−211
Authors: Agarwal Sushmita , Shukla Amit , Sharma Pranjali 
Published: January 2025

ABSTRACT
Variable $\gamma$-ray flares up to minute time-scales reflect extreme particle acceleration sites. However, for high-redshift blazars, the detection of such rapid variations remains limited by current telescope sensitivities. Gravitationally lensed blazars serve as powerful tools to probe $\gamma$-ray production zones in distant sources, with time delays between lensed signals providing crucial insights into the spatial distribution of emission regions relative to the lens’s mass-weighted centre. We have utilized 15 yr of Fermi–LAT $\gamma$-ray data from direction of PKS 1830–211 to understand the origin of flaring high-energy production zone at varying flux states. To efficiently estimate the (lensed) time delay, we used a machine learning-based tool – the Gaussian Process regression algorithm, in addition to – Autocorrelation function and Double power spectrum. We found a consistent time delay across all flaring activity states, indicating a similar location for the $\gamma$-ray emission zone, possibly within the radio core. The estimated time delay of approximately 20 d for the five flaring epochs was significantly shorter than previously estimated radio delays. This suggests that the $\gamma$-ray emission zone is closer to the central engine, in contrast to the radio emission zone, which is expected to be much farther away. A linear relationship between lag and magnification has been observed in the identified source and echo flares. Our results suggest that the $\gamma$-ray emission zone originates from similar regions away from the site of radio dissipation.