bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Calcium Propionate plus Propylene Glycol on the incidence of Calving-related Disorders in Transition Florida Dairy Cows fed Anionic Salts
Authors: Melendez Pedro , Donovan Art , Hall Mary B. , Risco Carlos , Goff Jesse 
Published: February 2023

Transition period in the dairy cow is characterized by tremendous physiological demands. Calving-related disorders (CRD) such as milk fever (MF), retained fetal membranes (RFM), metritis, fatty liver, ketosis, left and right displacement of abomasum (DA), mastitis, and lameness are common features. These disorders are interrelated and have a significant negative economic impact in dairy cattle operations. Any attempt to decrease the incidence of CRD will positively affect milk yield and reproductive performance.
The following field trial was conducted to determine the effect of a calcium-energy supplement on the incidence of calving-related disorders in Florida dairy cows.
Developing Fluid Administration Protocols in Bovine Practice
Authors: McGuirk Sheila M. 
Published: February 2023

In a variety of clinical disorders of cows and calves, dehydration develops because of fluid losses from the body. Normally, the volume and composition of body fluids are maintained in an extremely narrow range as excretion is matched to intake. Water intake from ingested water and feeds as well as endogenous water production balances water loss through the urine, gastrointestinal tract, respiratory tract and skin. The amount of a substance added by intake and endogenous production is equal to the amount eliminated by excretion or endogenous utilization. The urinary and gastrointestinal tracts are the major means by which cattle maintain water and electrolyte balance. Excesses can be managed by increased excretion but deficits must be corrected by increased intake.
The purpose of this paper is to identify the clinical conditions that are associated with dehydration in cattle, and to provide the assessment parameters that guide trained farm personnel to chose the best route of administration for an appropriate volume and concentration of rehydration fluids. The fluid protocols discussed in this paper will be based on body weight assumptions for a calf and cow of 100 and 1200 lb ( 45 and 550 kg), respectively.
Use of Ovsynch/TAI for Postpartum or Post-service Anestrus in Dairy Cows and Effects of Some Factors Affecting Conception Rate
Authors: Yamada K. , Nakao T. , Matsuda G. , Tanaka T. , Tokunaga T. , Numayama N. , Saito J. , Arai K. 
Published: February 2023

Postpartum as well as post-service anestrus is a major cause of a prolonged interval between calving and conception.
Ovulation synchronization/timed artificial insemination (OVS/TAI) is known to be effective to increase a submission rate after voluntary waiting period without heat detection. However, conception rates after OVS/TAI vary greatly among different herds. Factors contributing to the variation need to be clarified to improve the conception rate after OVS/TAI.
Occurrence of estrus prior to the day of timed insemination is another problem with this protocol. Objectives of this study are to show the effect of OVS/TAI for the treatment of postpartum or post-service anestrus, describe effects of some factors on the conception rate and to investigate the occurrence of estrus before the day of TAI.
Incorporating Consulting Into Veterinary Practice
Authors: Tyler Donald H. 
Published: February 2023

Our advice is important to every operation for which we provide consultation. Helping our clients make the right decision is not solely dependent on our ability to provide a logical analysis of all the factors that affect the current situation, but also on our ability to show the value, personal benefits and possible ramifications of utilizing the advice. The best advice possible has no value ifwe cannot help our clients understand it and make timely decisions concerning the welfare of their operation.
In my work in advising clients in the area of personnel management, manager coaching and professional development, transfer of the business to the next generation, and achieving higher production goals, it has become extremely important for me to help owners and managers alike make tough decisions. Though they understand the logic involved in the decision, emotion sometimes clouds the process and evokes hesitation. Many times our clients know that they must make a change, but tradition, habit, fear of failure and a natural resistance to change get in the way. This hesitation is only exacerbated by the emotions of depression, confusion and grief from extended financial distress.
An advisory methodology that incorporates an appreciation for these factors with an understanding of the emotional implications will provide greater success. Additionally, this appreciation will enhance a sense of camaraderie among all the decision-makers involved in the process.
Cooling towerLegionella pneumophilasurveillance results: Vancouver, Canada, 2021
Authors: Radziminski Christopher , White Phillip 
Published: February 2023

AbstractCooling towers have been linked to Legionnaires' disease cases and outbreaks. Legionella pneumophila results (from a culture-based method) are presented for 557 cooling towers across the City of Vancouver, Canada for 2021. Results of 10 CFU/mL or greater (defined as exceedances) were reported for 30 cooling towers (5.4%), including six &gt;1,000 CFU/mL, and L. pneumophila serogroup 1 (sg1) was identified in 17 of these cooling towers (out of 28 with serogroup-level analysis). The data indicate highly localised Legionella issues, with exceedances concentrated within 16 facilities, including two hospitals. In the 3 months preceding each cooling tower exceedance, the nearest municipal water sampling station had a free chlorine residual of at least 0.46 mg/L and a temperature of &lt;20 °C. There was not a statistically significant correlation between the L. pneumophila concentration of a cooling tower in exceedance and the municipal water free chlorine residual, temperature, pH, turbidity or conductivity. There was a statistically significant negative correlation between the concentrations of L. pneumophila sg1 and other L. pneumophila serogroups in cooling towers. This unique dataset underscores the pivotal role of building owners and managers in preventing the growth of Legionella bacteria and the value of regulations to verify operations and maintenance practices.
Deuterium Solvent Kinetic Isotope Effect on Enzymatic Methyl Transfer
Catalyzed by Catechol O-methyltransferase
Authors: Zipeng Zhao , Fangya Li , Jianyu Zhang 
Published: February 2023

Introduction::
Catechol o-methyltransferase plays a key role in the metabolism of
catecholamine neurotransmitters. At present, its catalytic mechanism, overall structure, and kinetic
characteristics have been basically clarified, but few people have paid attention to the function of
solvents on enzymatic methyl transfer reactions. The influence of solvents on enzymatic reactions has
always been a fuzzy hot topic. In addition, as a well-studied typical methyltransferase, COMT is a
good test bed for exploring the source of the solvent isotope effect, which is a powerful tool in
enzymatic mechanism research.

Methods::
We have measured the kinetic parameters of methyl transfer catalyzed by COMT in both
normal water (H2O) and heavy water (D2O) by high-performance liquid chromatography (HPLC) in
the range of pL 6 ~ 11

Results::
The kinetic characteristics of COMT in H2O and D2O were significantly different under
different pH/pD conditions. Significant solvent kinetic isotope effects (SKIE) were obtained, especially
inverse solvent kinetic isotope effects (SKIE < 1) were observed in this methyl transfer reaction for the
first time.

Conclusion::
Traditional factors which could interpret the solvent isotope effect were ruled out. It’s
suggested that the solvent might affect the overall conformation as well as the flexibility of protein
through non-covalent forces, thus altering the catalytic activity of COMT and leading to the solvent
isotope effect.
Triazolopyrimidine Derivatives: An Updated Review on Recent
Advances in Synthesis, Biological Activities and Drug Delivery Aspects
Authors: Abdelkhalek Ahmed S. , Attia Mohamed S. , Kamal Mohammad A. 
Published: February 2023

Abstract:
Molecules containing triazolopyrimidine core showed diverse biological activities,
including anti-Alzheimer's, anti-diabetes, anti-cancer, anti-microbial, anti-tuberculosis,
anti-viral, anti-malarial, anti-inflammatory, anti-parkinsonism, and anti-glaucoma activities.
Triazolopyrimidines have 8 isomeric structures, including the most stable 1,2,4-triazolo[1,5-
a] pyrimidine ones. Triazolopyrimidines were obtained by using various chemical reactions,
including a) 1,2,4-triazole nucleus annulation to pyrimidine, b) pyrimidines annulation to
1,2,4-triazole structure, c) 1,2,4-triazolo[l,5-a] pyrimidines rearrangement, and d) pyrimidotetrazine
rearrangement. This review discusses synthetic methods, recent pharmacological
actions and drug delivery perspectives of triazolopyrimidines.
Efficacy and Safety of Alirocumab and Evolocumab as Proprotein
Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors in Familial
Hypercholesterolemia: A Systematic Review and Meta-Analysis
Authors: Ghasempour Ghasem , Zamani-Garmsiri Fahimeh , Shaikhnia Farhad , Soleimani Ali Akbar , Hosseini  Fard Syed Reza , Leila Janani , Teimuri Shohreh , Parvaz Najmeh , Mohammadi Payam , Najafi Mohammad 
Published: February 2023

Background:
Familial hypercholesterolemia (FH) is a prevalent and potentially fatal illness
that causes a substantial elevation in low-density lipoprotein cholesterol (LDL-C).

Methods:
A comprehensive search was done on PubMed/MEDLINE, EMBASE, Web of Science
(WOS/ ISI), Scopus, ClinicalTrials (www.ClinicalTrials.gov), and conferences/ congress research
papers. Random effect models were used to calculate mean differences (%) and risk ratios (RRs),
and confidence intervals (95%).

Results:
Ten studies (n=1489 patients) were included in this study. PCSK9 inhibitors decreased the
levels of LDL-C by -49.59% (95%CI -55.5%, -43.67%) as compared to placebo. They also didn’t
alter the Treatment-Emergent Adverse Event (TEAE) and neuronal events by RR 0.92 (0.75, 1.13)
and 1.31 (0.66, 2.59), respectively. PCSK9 inhibitors were effective and safe in treating patients
with FH.

Conclusion:
There was high-quality evidence showing that monoclonal antibodies (alirocumab &
evolocumab) lower LDL-C (GRADE: high), lipoprotein (a) (GRADE: High), triglycerides (TG)
(GRADE: High), total cholesterol (GRADE: High), non-high-density lipoprotein cholesterol (non-
HDL-C) (GRADE: Moderate), and apolipoprotein B (GRADE: High), and increase the HDL-C
(GRADE: High) as well as apolipoprotein A1 (GRADE: High). Comparing PCSK9 inhibitors
against placebo, neither TEAE (GRADE: high) nor neuronal events (GRADE: moderate) were
changed.

Registration number:
PROSPERO-CRD42022334035
DL-3-n-butylphthalide Attenuates Cerebral Ischemia-Reperfusion Injury
by Inhibiting Mitochondrial Omi/HtrA2-Mediated Apoptosis
Authors: Huang Shuo , He Qianyan , Sun Xin , Qu Yang , Abuduxukuer Reziya , Ren Jiaxin , Zhang Kejia , Yang Yi , Guo Zhen-Ni 
Published: February 2023

Background:
Ischemic stroke is a major cause of death and disability worldwide and
results from inadequate cerebrovascular blood supply; mitochondrial dysfunction plays an essential
role in its pathogenesis. DL-3-n-butylphthalide (NBP) is an effective medicine for ischemic stroke
that reduces cell apoptosis and improves long-term prognosis.

Objective:
Whether and how NBP regulates mitochondria-associated apoptosis in cerebral ischemia-
reperfusion injury remains unclear.

Methods:
Male Sprague Dawley rats were subjected to a middle cerebral artery occlusion (MCAO)
stroke and treated with low (20 mg/kg) or high (80 mg/kg) concentrations of NBP. The Omi/HtrA2
inhibitor UCF-101 was used as a positive control. Cerebral infarction, neuron injury and neuronal
apoptosis were assessed to determine the efficacy of NBP compared to UCF-101. We assessed the
expression of the Omi/HtrA2 signaling pathway by western blotting and tested the mRNA expression
of mitochondrial metabolism-related genes by PCR.

Results:
Compared to the MCAO group, both low and high concentrations of NBP substantially
improved cerebral infarction, neuron injury, and neuronal apoptosis; high concentrations of NBP
were more potent than low concentrations. The expression of proteins of the mitochondrial
Omi/HtrA2 signaling pathway, including Omi/HtrA2, XIAP, PARL, OPA1, CHOP, and ClpP, was
inhibited in the NBP group.

Conclusion:
Overall, early application of NBP attenuated cerebral ischemia-reperfusion injury by
inhibiting mitochondrial Omi/HtrA2-mediated apoptosis in rats. Our study supports a novel neuroprotective
mechanism of NBP, making it a promising therapeutic agent for ischemic stroke.
Assessment of Wine Quality, Traceability and Detection of Grapes Wine,
Detection of Harmful Substances in Alcohol and Liquor Composition
Analysis
Authors: Shahrajabian Mohamad Hesam , Sun Wenli 
Published: February 2023

Abstract:
Wine production is the result of the interaction between various strains and grapes, and its
good quality is also affected by many factors. Aureobasidium, Cladosporium, Candida, Filobasidium,
Hanseniaspora, Hannaella, Saccharomyces, Wickerhamomyce, Alternaria, Starmerella, Acetobacter,
Papiliotrema, Bradyrhizobium, Leuconostoclia, Gluconobacter, Comamonas, and Massilia, are significantly
correlated with changes of physiological properties and volatile compounds. Phenolic compounds,
shortened as phenolics, are a vital parameter to the quality of wine, and wine phenolics include two main
families: non-flavonoids, which consist of hydroxybenzoic acids (HBAs), hydroxycinnamic acids
(HCAs), and stilbenes, and flavonoids, comprising flavonols, flavan-3-ols, and anthocyanins. Wine quality
is determined by either sensory tests or physicochemical tests, and the latter analyse the wine’s chemical
parameters such as sugar, pH, and alcohol level. The most important constituents found in wine are
Terpenes; Aldehydes, Pyrazines, Esters, Ketones and diketones, Mercaptans, and Lactones. In wine quality
analysis, the most chief variables are volatile acidity, alcohol, sulphates, citric acid, density, total sulfur
dioxide, chlorides, pH, fixed acidity, free sulfur dioxide, and residual sugar. Some classifiers utilized for
wine quality prediction in machine learning are: k-Nearest Neighbor (KNN), Random Forest, Decision
Tree, Support Vector Machines, Linear Regression, Stochastic Gradient Descent, Artificial Neural Networks
(ANN), and Naive Bayes. This article is aimed to review wine quality parameters, detection and
traceability of wine, and detection of harmful substances in alcohol and liquor composition analysis.
Azo Based Chromogenic Sensor: An Approach for Naked Eye Detection of Biologically Relevant Anions and Metal Cations
Authors: Damade Kanchan Ramsingh , Hiraman More Dhananjay 
Published: February 2023

Abstract:
It was previously reported that azo compounds are vigorous and chemically stable compounds
and well-known chromophores. Having different chromophores, the azo dyes act as probing
units for capturing the charged particles either by electron transfer or deprotonation mechanisms. The
probing efficiency usually exhibits in the magnitude of variations in UV absorbance, NMR peaks and
visually observed color changes. The sensing application is a prerequisite for numerous analytical
techniques involved in pharmaceutical as well as pathological discipline. In the last two decades,
numerous azo based sensors have been developed, which render low cost and effective sensing approaches
towards ionic diagnosis through instantaneous eye beaming chromogenic change. This
sensing approach is simple, cost-effective, and precise and provides reliable quantitative and qualitative
statistics of an analyte present in a complex environment. Our present study culminates the recent
progress on the synthesis of azo compounds and their chromogenic sensing application towards
various reactive analytes through reviewing spectral variations and colorimetric observations. This
review article assesses the potential of azo dyes in chromogenic sensing for different analytes. We
believe this review will be of interest and important for researchers working on designing azo-based
chromogenic sensors.
The Perceived Support Received by Women with Breast Cancer during
the COVID-19 Pandemic: A Qualitative Study
Authors: Heidari Haydeh , Mardani-Hamooleh Marjan , Pezaro Sally 
Published: February 2023

Background:
Women with breast cancer in Iran face challenges requiring support. Yet the
provision of support may have changed during the coronavirus disease 2019 (COVID-19) pandemic.

Objective:
The aim of the present study was to explore the perceptions of women with breast cancer
about the support they received during the COVID-19 pandemic.

Methods:
This study was qualitative in nature. Semi-structured interviews were conducted with Iranian
women with breast cancer. The interviews were transcribed verbatim and analysed via conventional
content analysis.

Results:
Participants (n = 33) were Iranian women aged 29-58 years. All women included were married
and were working in the role of a housewife. Women's perceptions of breast cancer during the
COVID-19 pandemic of support were identified under two main categories; Constructive support and
Lack of support. Sub-categories related to constructive support included receiving support from family,
peers, and nurses. Sub-categories related to lack of support included a perceived lack of spousal
and sociocultural support.

Conclusion:
Anti-stigma interventions (AS interventions) are suggested to increase both spousal and
sociocultural support in this context. Further studies may usefully be conducted with the participation
of Iranian women's family members in order to gain a deeper understanding of the support received
and required by Iranian women with breast cancer during the COVID-19 pandemic and beyond.
Synthesis and SAR of Potential Anti-Cancer Agents of Quinoline
Analogues: A Review
Authors: Tyagi Sonakshi , Salahuddin  , Mazumder Avijit , Kumar Rajnish , Datt Vimal , Shabana Km , Yar Mohammad Shahar , Ahsan Mohamed Jawed 
Published: February 2023

Abstract:
Quinoline has recently become an important heterocyclic molecule due to its numerous
industrial and synthetic organic chemistry applications. Quinoline derivatives have been used in clinical
trials for a variety of medical conditions that causes cancer. The present literature study is composed
of recent progress (mainly from 2010 to the present) in the production of novel quinoline derivatives
as potential anti-cancer agents, as well as their structure-activity relationship, which will
provide insight into the development of more active quinoline hybrids in the future.

:
The present review comprises the synthetic protocols of biologically active Quinoline analogs with
their structure-activity relationship studies as anti-cancer agents, which provide depth view of work
done on quinoline derivatives to the medicinal chemist for future research.
Tacrolimus and Azole Derivatives of Agricultural and Human Health
Importance: Prediction of ADME Properties
Authors: Antypenko Lyudmyla , Shabelnyk Konstyantyn , Kovalenko Sergiy 
Published: February 2023

Introduction:
Agricultural chemicals are impacting health nowadays. Recently, promising
synergistic antifungal interaction between tacrolimus and some azole compounds was studied.

Objectives:
To determine ADME parameters, potential side effects of test substances to reduce
time and resources in the future

Methods:
All descriptors and molecular parameters were obtained by the protocols of
SwissADME and ProTox II.

Results:
In the result, the following physicochemical and drug-likeness parameters were calculated.

Conclusion:
Studied triazoles 1 and 2 showed good ADME characteristics and promising toxicity
levels suitable to be checked for in vitro toxicology in case of future advanced results in the
agricultural field.
Evaluation of the Effectiveness of Remdesivir in the Treatment of
COVID-19 Outpatients: A Retrospective Cohort Study
Authors: Foroghi Ghomi Seyed Yaser , Mohammadbeigi Abolfazl , Ahmadi Abbas , Ahmadpour Sajjad , Shakeri Mansoureh , Adeli Seyed Hasan , Vafaeimanesh Jamshid , Tabaraii Reihane , Shajari Rasoul , Vahedian Mostafa , Asghari Akram 
Published: February 2023

Background:
The outbreak of acute respiratory syndrome with novel coronavirus 2019
(COVID-19) in December 2019 in Wuhan, China, caused a worldwide outbreak of the disease. To
treat the disease, some drugs were identified and introduced that did not show a significant effect on
the recovery of the disease. Due to the need to manage inpatient beds, this study was conducted to
evaluate the effectiveness of Remdesivir in the treatment of outpatients with moderate to severe
COVID-19.

Methods:
The present study was a retrospective cohort with a convenience sampling method. It was
conducted by referring to the records of COVID-19 patients who were referred to the respiratory clinic
of Shahid Beheshti Hospital as outpatients in the period from April to August 2021.

Results:
This study was conducted on 263 COVID-19 patients with a mean age of 51.16±14.39 years
from 19 and 90 years old. Data were collected through a researcher-made checklist and analyzed using
SPSS 20. Kolmogorov-Smirnov test, paired t-test, and Mc Nemar's test were used to evaluate the data.
The significance level was considered at the level of 0.05.

Conclusion:
Findings revealed that no clear correlation was found between hospitalization and death
rate compared to other patients. In our study, the risk factors for severe COVID-19 did not affect the
rate of hospitalization or death of patients.