bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple and efficient strategy for cell‐based and cell‐free‐based therapies in acute liver failure: hUCMSCs bioartificial liver
Authors: Feng Lei , Wang Yi , Fu Yu , Yimamu Adilijiang , Guo Zeyi , Zhou Chenjie , Li Shao , Zhang Linya , Qin Jiasheng , Liu Shusong , Xu Xiaoping , Jiang Zesheng , Cai Shaoru , Zhang Jianmin , Li Yang , Peng Qing , Yi Xiao , He Guolin , Li Ting , Gao Yi 
Published: June 2023

AbstractAcute liver failure (ALF) is a life‐threatening condition. Cell‐based and cell‐free‐based therapies have proven to be effective in treating ALF; however, their clinical application is limited by cell tumorigenicity and extracellular vesicle (EV) isolation in large doses. Here, we explored the effectiveness and mechanism of umbilical cord mesenchymal stem cells (hUCMSCs)‐based bioartificial liver (hUCMSC‐BAL), which is a simple and efficient strategy for ALF. D‐galactosamine‐based pig and mouse ALF models were used to explore the effectiveness of hUCMSC‐BAL and hUCMSC‐sEV therapies. Furthermore, high‐throughput sequencing, miRNA transcriptome analysis, and western blot were performed to clarify whether the miR‐139‐5p/PDE4D axis plays a critical role in the ALF model in vivo and in vitro. hUCMSC‐BAL significantly reduced inflammatory responses and cell apoptosis. hUCMSC‐sEV significantly improved liver function in ALF mice and enhanced the regeneration of liver cells. Furthermore, hUCMSC‐sEV miRNA transcriptome analysis showed that miR‐139‐5p had the highest expression and that PDE4D was one of its main target genes. The sEV miR‐139‐5p/PDE4D axis played a role in the treatment of ALF by inhibiting cell apoptosis. Our data indicate that hUCMSC‐BAL can inhibit cytokine storms and cell apoptosis through the sEV miR‐139‐5p/PDE4D axis. Therefore, we propose hUCMSC‐BAL as a therapeutic strategy for patients with early ALF.
Macrophage‐based delivery of anti‐fibrotic proteins alleviates bleomycin‐induced pulmonary fibrosis in mice
Authors: Liu Huiying , Yang Cuiping , Gao Yun , Zhang Xueli , Wang Min , Yu Xinting , Wang Weidong , Xie Lixin , Tang Ping , Yin Xiushan , Bai Changqing , Zhang Luo 
Published: June 2023

AbstractIdiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by chronic, progressive, and fibrotic lung injury. Although remarkable progress has been made toward understanding the pathogenesis of PF, finding more effective treatments for this fatal disease remains a challenge. In this study, we describe an innovative macrophage‐based approach to deliver anti‐fibrotic protein to the lung and inhibit PF in a mouse model of bleomycin (BLM)‐induced lung injury. We engineered macrophages to continuously secrete three types of proteins: interleukin‐10, which prevents inflammation; TGFRcFc, a soluble truncated TGF‐βR2 that blocks TGF‐β; and CD147, which induces matrix metalloproteinases (MMPs) and causes collagen degradation. Infusing these engineered macrophages into the lungs of BLM‐induced PF mouse models in an optimal pattern significantly ameliorated PF in mice. Specifically, the most effective therapeutic outcome was achieved by infusing IL‐10‐secreting macrophages on day 1, followed by TGFRcFc‐secreting macrophages on day 7 and CD147‐secreting macrophages on day 14 into the same mice after BLM treatment. Our data suggest that macrophage‐based delivery of anti‐fibrotic proteins to the lungs is a promising therapy for fibrotic lung disorders.
Prophylactic treatment of dacomitinib‐induced skin toxicities in epidermal growth factor receptor‐mutated non–small‐cell lung cancer: A multicenter, Phase II trial
Authors: Iwasaku Masahiro , Uchino Junji , Chibana Kenji , Tanzawa Shigeru , Yamada Takahiro , Tobino Kazunori , Uchida Yasuki , Kijima Takashi , Nakatomi Katsumi , Izumi Miiru , Tamiya Nobuyo , Kimura Hideharu , Fujita Masaki , Honda Ryoichi , Takumi Chieko , Yamada Tadaaki , Kaneko Yoshiko , Kiyomi Fumiaki , Takayama Koichi 
Published: June 2023

AbstractBackgroundDacomitinib significantly improves progression‐free survival and overall survival (OS) compared with gefitinib in patients with non–small‐cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR)‐activating mutations. However, dacomitinib often causes skin toxicities, resulting in treatment discontinuation. We aimed to evaluate a prophylactic strategy for skin toxicity induced by dacomitinib.MethodsWe performed a single‐arm, prospective, open‐label, multi‐institutional phase II trial for comprehensive skin toxicity prophylaxis. Patients with NSCLC harboring EGFR‐activating mutations were enrolled and received dacomitinib with comprehensive prophylaxis. The primary endpoint was the incidence of skin toxicity (Grade ≥2) in the initial 8 weeks.ResultsIn total, 41 Japanese patients participated between May 2019 and April 2021 from 14 institutions (median age 70 years; range: 32–83 years), 20 were male, and 36 had a performance status of 0–1. Nineteen patients had exon 19 deletions and L858R mutation. More than 90% of patients were perfectly compliant with prophylactic minocycline administration. Skin toxicities (Grade ≥2) occurred in 43.9% of patients (90% confidence interval [CI], 31.2%–56.7%). The most frequent skin toxicity was acneiform rash in 11 patients (26.8%), followed by paronychia in five patients (12.2%). Due to skin toxicities, eight patients (19.5%) received reduced doses of dacomitinib. The median progression‐free survival was 6.8 months (95% CI, 4.0–8.6 months) and median OS was 21.6 months (95% CI, 17.0 months–not reached).ConclusionAlthough the prophylactic strategy was ineffective, the adherence to prophylactic medication was quite good. Patient education regarding prophylaxis is important and can lead to improved treatment continuity.
Impact of comorbidities on people with and without cancer early in the COVID‐19 pandemic: An observational study
Authors: Schwartz Carolyn E. , Rapkin Bruce D. 
Published: June 2023

AbstractBackgroundThe present study sought to investigate how comorbidity burden influences cancer survivors' quality of life (QoL) and the challenges/adaptations during the coronavirus disease 2019 (COVID) pandemic, and to examine how appraisal processes are related to this impact.MethodsThis cross‐sectional study, administered in spring/summer 2020, compared cancer survivors to a general‐population comparison sample. QoL was assessed with standardized tools. COVID‐specific questions included selected items compiled by the US National Institutes of Health, and cognitive appraisal processes were assessed using the QoL Appraisal Profilev2 Short‐Form. Principal components analysis reduced the number of comparisons. Multivariate analysis of covariance investigated group differences in QoL, COVID‐specific variables, and cognitive‐appraisal processes. Linear regression investigated group differences in COVID‐specific variables as a function of cognitive‐appraisal processes, QoL, demographic covariates, and their interactions.ResultsCancer survivors fared substantially better than non‐cancer participants in QoL and cognitive functioning when they had no other comorbidities, but substantially worse on QoL when they had three or more comorbidities. Cancer survivors with no comorbidities were less likely to feel worried about COVID, less likely to engage in self‐protection, and prioritized engaging in problem‐focused and prosocial actions compared to non‐cancer participants. Conversely, cancer survivors confronted with multiple comorbidities exhibited more proactive self‐protection and experienced more anxiety about the pandemic.ConclusionThe impact of having multiple comorbidities in the context of cancer is associated with notable differences in social determinants of health, QoL outcomes, COVID‐specific challenges/adaptations, and appraisal of QoL. These findings provide an empirical basis for implementing appraisal‐based coping interventions.
The road to learning “who am I” is digitized: A study on consumer self‐discovery through augmented reality tools
Authors: Ambika Anupama , Belk Russell , Jain Varsha , Krishna Rajneesh 
Published: June 2023

AbstractToday, digital tools offer multiple avenues for consumers to learn about themselves. Self‐discovery or knowing “who am I” is fundamental to our everyday experience. However, there is a paucity of research that investigates the “how and why” of self‐discovery, made possible by technological advancements. Adopting the theoretical tenets of extended self, possible selves, storied selves, and the twin metaphors of self and identity, we follow a multimethod qualitative approach to explore consumer self‐discovery in the context of AR‐based makeup and grooming apps and filters. We establish a framework for AR‐facilitated self‐discovery by analyzing the data obtained via Netnography and 22 in‐depth interviews. The findings suggest that digital tools enable the discovery of previously unknown facets of the consumers' self‐concept. Theoretically, this study demystifies the process of technology‐enabled self‐discovery, which is related to better life decisions and consumer well‐being. Brands may apply these insights to inculcate the discovery components into the AR design, which can facilitate the adoption of new products. Finally, this study highlights the possible challenges to be avoided to ensure consumer well‐being while using AR‐enabled digital tools.
Paclitaxel inhibits hepatocellular carcinoma tumorigenesis by regulating the circ_0005785/miR‐640/GSK3β
Authors: Yang Xianwu , Tian Xiaojuan , Zhao Pengcheng , Wang Zheng , Sun Xuedong 
Published: June 2023

AbstractPaclitaxel (PTX) is an effective chemotherapeutic agent for cancer patients. It has been reported that circular RNA (circRNA) circ_0005785is involved in the progression of hepatocellular carcinoma (HCC). The purpose of this study is to explore the role and mechanism of circ_0005785 in the PTX resistance of HCC. Cell viability, proliferation, invasion, migration, apoptosis, and angiogenesis were detected using 3‐(4, 5‐dimethyl‐2‐thiazolyl)‐2, 5‐diphenyl‐2‐H‐tetrazolium bromide (MTT), colony formation, transwell, wound‐healing, flow cytometry, and tube formation assay. Circ_0005785, microRNA‐640 (miR‐640), and Glycogen synthase kinase‐3 beta (GSK3β) levels were detected using real‐time quantitative polymerase chain reaction. Protein levels of Proliferating cell nuclear antigen (PCNA), Bcl‐2, and GSK3β were measured using western blot assay. After being predicted using Circular RNA interactome or TargetScan, binding between miR‐640 and circ_0005785 or GSK3β was verified using dual‐luciferase reporter and RNA Immunoprecipitation assay. PTX treatment could repress HCC cell viability, decrease circ_0005785 and GSK3β expression, and increase the miR‐640 level in HCC cell lines. Furthermore, circ_0005785 and GSK3β were increased, and miR‐640 was decreased in HCC tissues and cell lines. Moreover, circ_0005785 knockdown hindered proliferation, migration, invasion, angiogenesis, and boosted apoptosis in PTX‐treated HCC cells in vitro. In addition, circ_0005785 silencing improved the PTX sensitivity of HCC in vivo. Mechanistically, circ_0005785 acted as a sponge of miR‐640 to regulate GSK3β expression. PTX restrained HCC tumorigenesis partly via regulating the circ_0005785/miR‐640/GSK3β axis, hinting at a promising therapeutic target for the HCC treatment.
Homelessness and predictors of criminal reoffending: A retrospective cohort study
Authors: Mitchell Rebecca J. , Burns Nicholas , Glozier Nicholas , Nielssen Olav 
Published: June 2023

AbstractBackgroundThere are not many longitudinal studies examining people experiencing homelessness and interacting with the criminal justice system over time.AimsTo describe the type of criminal offences committed, court outcomes, identify probable predictors of reoffending, and estimate the criminal justice costs in a cohort of homeless hostel clinic attendees.MethodA retrospective cohort study of 1646 people attending a homeless clinic who had had contact with the criminal justice system (CJS) in New South Wales (NSW), Australia, using linked clinic, criminal offence, health and mortality data from 1 July 2008 to 30 June 2021. Initial comparisons were made with the 852 clinic attendees without CJS contact in the period. Multivariable logistic regression was used to identify predictors of recidivism.ResultsThere were 16,840 offending episodes, giving an offence rate of 87.8 per 100 person‐years (95%CI: 86.5–89.1). The most common index offences were acts intended to cause injury (22%), illicit drug (17%) and theft‐related (12%) offences. Most people (83%) were found guilty of the index offence and received a fine (37%) or community‐based sentence (29%). Total court finalisation costs were AUD $11.3 million. Three‐quarters of those convicted reoffended within 24 months. Offenders were more likely to be younger, have a diagnosis of personality disorder (AOR: 1.31; 95% CI: 1.04–1.67), a substance use disorder (AOR: 1.60; 95% CI 1.14–2.23) and/or to have a previous charge dismissed on mental health grounds (AOR: 1.79; 95% CI: 1.31–2.46). Within the offending cohort, reoffenders had almost twice the odds of having theft‐related offences as their principal index offence (AOR: 1.85; 95% CI: 1.29–2.66).ConclusionsThis longitudinal study finding of not only a high rate of criminal justice contact, but also a high rate of recidivism among people who have been homeless, lends support to a need for strategies both to address the root causes of homelessness and to provide a comprehensive systems‐based response to reduce recidivism, that includes secure housing as well as mental health and substance use treatment programmes for homeless offenders.
Comparison of interventions for intermediate to high‐risk pulmonary embolism: A network meta‐analysis
Authors: Ishisaka Yoshiko , Watanabe Atsuyuki , Fujisaki Tomohiro , Iwagami Masao , So Matsuo , Steiger David , Aoi Shunsuke , Secemsky Eric A. , Wiley Jose , Kuno Toshiki 
Published: June 2023

AbstractBackgroundMultiple interventions, including catheter‐directed therapy (CDT), systemic thrombolysis (ST), surgical embolectomy (SE), and therapeutic anticoagulation (AC) have been used to treat intermediate to high‐risk pulmonary embolism (PE), but the most effective and safest treatment remains unclear. Our study aimed to investigate the efficacy and safety outcomes of each intervention.MethodsWe queried PubMed and EMBASE in January 2023 and performed a network meta‐analysis of observational studies and randomized controlled trials (RCT), including high or intermediate‐risk PE patients, and comparing AC, CDT, SE, and ST. The primary outcomes were in‐hospital mortality and major bleeding. The secondary outcomes included long‐term mortality (≥6 months), recurrent PE, minor bleeding, and intracranial hemorrhage.ResultsWe identified 11 RCTs and 42 observational studies involving 157,454 patients. CDT was associated with lower in‐hospital mortality than ST (odds ratio [OR] [95% confidence interval (CI)]: 0.41 [0.31−0.55]), AC (OR [95% CI]: 0.33 [0.20−0.53]), and SE (OR [95% CI]: 0.61 [0.39−0.96]). Recurrent PE in CDT was lower than ST (OR [95% CI]: 0.66 [0.50−0.87]), AC (OR [95% CI]: 0.36 [0.20−0.66]), and trended lower than SE (OR [95% CI]: 0.71 [0.40−1.26]). Notably, ST had higher major bleeding risks than CDT (OR [95% CI]: 1.51 [1.19−1.91]) and AC (OR [95% CI]: 2.21 [1.53−3.19]). By rankogram analysis, CDT presented the highest p‐score in in‐hospital mortality, long‐term mortality, and recurrent PE.ConclusionIn this network meta‐analysis of observational studies and RCTs involving patients with intermediate to high‐risk PE, CDT was associated with improved mortality outcomes compared to other therapies, without significant additional bleeding risk.
Bilateral spontaneous pneumothorax as a late complication of COVID‐19, a clinical case report
Authors: Naghavi Fakhri , Ghiasvand Fereshteh , Moradi Maryam 
Published: June 2023

Key Clinical MessageBilateral spontaneous pneumothorax and sudden dyspnea can occur as late complication in patients with COVID‐19 even without any history of mechanical ventilation usage.AbstractBilateral spontaneous pneumothorax can occur as a late complication in patients with COVID‐19, even without any history of mechanical ventilation. Here, we present a patient with mild COVID‐19 pneumonia with a left massive pneumothorax in the third week of hospitalization and the addition of a right pneumothorax.
Acute vision loss due to CML leukemic retinopathy reversed with leukapheresis
Authors: Leong Sally , Do Tiffanie , Shodiya Michael , Lee Jennifer 
Published: June 2023

AbstractLeukemic retinopathy is a severe complication of severe leukocytosis that results from untreated chronic myelogenous leukemia (CML). Immediate cytoreduction via leukapheresis may reverse ocular manifestations and prevent permanent vision damage. We present a case of a patient with acute unilateral vision loss found to have leukemic retinopathy in the setting of untreated CML with improvement of visual symptoms after leukapheresis and initiation of hydroxyurea.
Management of huge verrucous carcinoma of lower lip: A case report at a tertiary hospital in northern Tanzania
Authors: Nnko Kanankira A. , Rwakatema Deogratius S. , Bina Steven M. , Mwita Samweli F. , Mremi Alex 
Published: June 2023

Key Clinical MessageWell‐differentiated variant of squamous cell carcinoma. Slow growing, exophytic, cauliflower‐like growth easily confused with a viral wart. Cutaneous, anogenital, and oral variant exist. Risk factors for oral variant include alcohol and smoking. Histopathologically exhibits lobules with a pushing margin and blunt borders.AbstractVerrucous carcinoma (VC) is a low‐grade variant of squamous cell carcinoma with specific clinicopathologic features and good prognosis when affecting skin. We report the case VC of lip in a‐70‐year‐old lady. She underwent surgical excision with excellent outcomes. A brief review of the literature is provided.
Ceftriaxone‐induced neutropenia successfully overcome by a switch to penicillin G in Cardiobacterium hominis endocarditis
Authors: Nau Roland , Schmidt‐Schweda Stephan , Frank Tobias , Gossner Johannes , Djukic Marija , Eiffert Helmut 
Published: June 2023

AbstractLeukopenia, including agranulocytosis, is a severe complication of treatment with all β‐lactam antibiotics. Its incidence increases with age. Cardiobacterium hominis endocarditis after implantation of an aortic valve bio‐prosthesis in a 77‐year‐old woman was treated with ceftriaxone 2 g/day plus gentamicin 160 mg/day intravenously. On Day 25 of treatment, blood leukocytes had decreased to 1800/μl (neutrophils 370/μl). Antibiotic therapy was switched to penicillin G 20 million international units (IU)/day. Thereafter, blood leukocytes including neutrophils normalized suggesting that penicillin G was less bone marrow‐toxic than ceftriaxone. High‐dose ciprofloxacin, the alternative to penicillin G, was avoided because of the risk of cognitive and behavioral side effects. The present case suggests that with close laboratory monitoring a β‐lactam with differing side chains should not be considered contraindicated after β‐lactam antibiotic‐induced neutropenia.
Pneumonia due to Mycobacterium cosmeticum in a patient with systemic sclerosis: A case report
Authors: Hu Yueqin , Zhang Chao , Jia Liangliang 
Published: June 2023

Key Clinical MessagePulmonary infection due to Mycobacterium cosmeticum was reported in only two patients previously. More studies are warranted to define its characteristics and treatments. We report a systemic sclerosis patient who had a pulmonary infection due to M. cosmeticum and then successfully recovered after treatment with combination antibiotic regimen.
Bicondylar Hoffa fracture with concurrent medial and lateral collateral ligament avulsion: A case report
Authors: Noorigaravand Sajad , Heidari Razieh , Tayyebi Hamed , Shirvani Saeid , Amiri Shayan 
Published: June 2023

AbstractHoffa fractures are rare fractures of the femoral condyle that occur in the coronal plane of the bone. In most cases, high‐energy trauma leads to isolated coronal fractures of one of the femoral condyles, medial or lateral. Even with a typical unicondylar Hoffa fracture, our patient sustained a bicondylar Hoffa fracture in his right knee after falling from high and suffering direct trauma as well. The fracture was approached from both the medial and lateral sides of the distal femur. Three‐month follow‐up showed excellent functional scores, no laxity, and no pain.
Exploring the relationship between investors' financial literacy and advisor use with securities‐based loans
Authors: Sommer Matthew , Todd Timothy M. , Lim HanNa 
Published: June 2023

AbstractPast literature has explored the characteristics of individuals who use high‐interest and tax‐inefficient consumer debt products, such as carrying a monthly credit card balance and engaging with alternative financial services. That literature revealed that users of these debt products tended to be financially constrained households faced with an immediate liquidity need, and that they had lower levels of financial literacy. Much less is known, however, about the role financial literacy may play when a more advantageous solution may be available but not used—an example of which is securities‐based loans, which offer lower rates and potential tax preferences. Therefore, this study used the 2018 National Financial Capability Study to examine why investors use traditional debt products when they could likely have qualified for a securities‐based loan. Using bounded rationality as a theoretical framework, this research advances the literature in consumer debt and borrowing decisions. The results found that objective knowledge, as opposed to self‐assessed ability or confidence, explained the use of optimal debt products. Additionally, advisor engagement was positively associated with securities‐based loan use.
2‐Silylated Dihydroquinazolinone as a Photocatalytic Energy Transfer Enabled Radical Hydrosilylation Reagent
Authors: Uchikura Tatsuhiro , Nakamura Haruka , Sakai Hinata , Akiyama Takahiko 
Published: June 2023

AbstractThe hydrosilylation of alkenes is one of the most important methods for the synthesis of organosilicon compounds. In addition to the platinum‐catalyzed hydrosilylation, silyl radical addition reactions are notable as economic reactions. An efficient and widely applicable silyl radical addition reaction was developed by using 2‐silylated dihydroquinazolinone derivatives under photocatalytic conditions. Electron‐deficient alkenes and styrene derivatives underwent hydrosilylation to give addition products in good to high yields. Mechanistic studies indicated that the photocatalyst functioned not as a photoredox catalyst but as an energy transfer catalyst. DFT calculations clarified that the triplet excited state of 2‐silylated dihydroquinazolinone derivatives released a silyl radical through the homolytic cleavage of a carbon‐silicon bond, and this was followed by the hydrogen atom transfer pathway, not the redox pathway.
Approach and avoidance motivations in response to being envied at work and their effects on proactivity
Authors: David Timea , Shih Hsi‐An 
Published: June 2023

AbstractThe goal of the present study is to provide a deeper analysis of the envy‐proactivity link. Drawing upon regulatory theories and Smith's model on envy appraisal, we theorize that when envied individuals focus on the potential negative impact of envy on themselves, they adopt avoidant coping strategies, which hinder proactivity, whereas concern toward others stimulates approach‐motivated coping strategies, which foster proactivity. Specifically, our model operationalizes a parallel mediating mechanism between perceptions of being envied and proactivity via the serial mediation of self‐oriented concern and distancing, and other‐oriented concern and courtesy. Results from a multi‐source survey confirm that being envied indirectly decreases proactivity via the serial mediation of self‐oriented concern and distancing, and indirectly increases proactivity via other‐oriented concern and courtesy.