bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mandated Public Disclosure and Trade Credit Payment Practices
Authors: Boghossian Mirna , Carnes Robert R. 
Published: February 2025

ABSTRACTWe investigate the efficacy of mandated public disclosure to improve firms’ trade credit payment practices. We exploit a regulation adopted by the United Kingdom in 2017 that mandates firms meeting certain size criteria to disclose information about their payment practices toward their trade suppliers. Using a difference‐in‐differences research design combined with a regression discontinuity approach for a sample of firms just above and below the mandatory disclosure size criteria, we find that firms disclosing supplier payment information reduce the number of days they take to pay their trade credit. Further, this effect is concentrated in firms with higher liquidity and lower leverage. After performing robustness tests, we explore two potential channels that could explain our findings. First, we consider whether firms are responding to pressure from suppliers in competitive industries. Second, we investigate whether firms are managing their external reputations. Using the Herfindahl–Hirschman Index to measure industry competitiveness, and firms that sell to end consumers and their market share to measure reputational exposure, we find evidence consistent with both explanations. Collectively, these findings suggest that disclosure motivates firms to improve their payment practices; however, this effect appears to be limited to firms with the financial flexibility to respond.
Strain‐Dependent Performance of Spodoptera frugiperda on Cabbage
Authors: Zhang Zhichun , Niu Hongtao , Zhao Dongxiao , Dai Hanyang , Sun Shuai , Zhang Haibo , Guo Huifang 
Published: February 2025

ABSTRACTThe invasion of fall armyworm, Spodoptera frugiperda, originating from the Americas, into numerous provinces of China has emerged as a significant threat to the nation's grain crop production. Other than crops, will S. frugiperda be a threat to vegetable crops in China? Here, we firstly surveyed the occurrence of S. frugiperda in cabbage field in Jiangsu province, China, and then, we detected the strain composition of the natural population on cabbage; after that, we compared the performance of all the field strains on cabbage in the lab. In 2021, S. frugiperda was found in field cabbage in three sites in Jiangsu province, and there were three strains, namely COIcorn‐Tpicorn strain (COICS‐TpiCS), COIrice‐Tpicorn strain (COIRS‐TpiCS) and COIrice‐Tpirice strain (COIRS‐TpiRS); the dominant strain in Haian and Luhe was COICS‐TpiCS and COIRS‐TpiCS, respectively. Further investigation on the performance of the three strains on cabbage leaves showed that both the survival rate of larvae and the fecundity of the strain COIRS‐TpiCS were significantly higher than that of the other two strains, whether fed on seedlings or ball leaves, which showed divergent performance among the three strains on cabbage. These findings underscore the potential threat posed by S. frugiperda to vegetable production in China.
Effect of Blanching, Ultrasonication and Pulsed Electric Field as Pretreatment on Acrylamide Mitigation and Overall Quality of Jackfruit Chips
Authors: Anilkumar Karthimol , Tangirala A. D. Srikanth , Hema V. , Anandakumar S. , Sunil C. K. , Rawson Ashish 
Published: February 2025

ABSTRACTIn this study, blanching, ultrasonication, and pulsed electric field were used as pretreatment prior to frying to mitigate acrylamide formation in jackfruit chips. Application of pretreatments effectively reduced acrylamide and its precursor content in chips. Structural modification on product introduced by all three pretreatments resulted in leaching of acrylamide precursors. Comparing all the pretreatment applied ultrasound treatment at 22 kHz (U1) showed effective mitigation of acrylamide along with superior organoleptic and nutritional properties. The lowest reducing sugar content (1.99 g/100 g) and a reduced asparagine content (0.001 mg/g) in U1 limited acrylamide formation. Nutritional, biochemical, physical and sensory properties of the products were analyzed and results reveals application of all three pretreatments at optimized condition as potential tool to produce jackfruit chips with desired quality and limited acrylamide.
Traditional cultural expressions and copyright law: Denoting the long‐lasting confusion
Authors: Aroian Mariam 
Published: February 2025

AbstractThe paper shows that protecting traditional cultural expressions through the scope of copyright law is an erroneous approach and that recognition of folklore should be a separate issue outside of the copyright scope. It examines the key incompatibilities between the individualistic nature of copyright and the collective, culturally embedded nature of TCEs. This research aims to contribute to the debate on how to develop an approach that, firstly, respects and effectively protects the unique nature of TCEs, and secondly, has a greater chance of gaining international acceptance. By drawing on the familiar concepts of attribution and integrity, we can create a new legal framework that addresses the needs of various groups of stakeholders and ensures that TCEs are properly protected both now and in the future. While the concepts of attribution and integrity, as developed in copyright law, cannot be applied directly to TCEs due to their individualistic nature, the paper argues that these concepts offer valuable insights for lawmaking purposes. By drawing from the extensive research in copyright studies, this paper suggests that these insights can guide the development of a sui generis protection system tailored to TCEs.
The Australian Plant Breeder's Rights Act 1994 (Cth) and how it is used for Australian native plants
Authors: Lawson Charles , Pickering Catherine 
Published: February 2025

AbstractWith increasing interest in intellectual property relating to plants, it is timely to assess the use of Plant Breeder's Rights (PBRs) in Australia for native plants, with tens of thousands of native plants nearly all of which are endemic and many with known uses. A database of all applications received, accepted, granted and grants expired or withdrawn, refused and rejected for PBRs under the Australian Plant Breeder's Rights Act 1994 (Cth) from 10 November 1994 to 14 December 2022 was assessed including plants native to Australia. The analysis revealed: There are over 9500 applications and over 5180 granted, of which ~10 percent are for native plants; many PBR owners are Australian residents (~50%), but even more so for native plant PBRs (96%); few PBRs last the full term (average duration 6.6 years); and overwhelmingly PBRs of native plants are ornamentals (~92%). There is potential for breeding more native ornamentals, but particularly food crops and medicinal plants. This includes expanding commercial development by Australia's First Nations communities including enterprises based on their ‘Indigenous Knowledge’. Further research can help identify why PBRs are not used for breeding more varieties including native food and medicinal plants with potential taxa and uses assessed.
Rencofilstat Treatment Improves Liver Function in MASH With Advanced Fibrosis as Quantified by HepQuant DuO
Authors: Harrison Stephen A. , Mayo Patrick , Hobbs Todd , Zhao Caroline , Canizares Carlos , Foster Robert , McRae Michael P. , Helmke Steve M. , Everson Gregory T. 
Published: February 2025

ABSTRACTBackground and AimsRencofilstat inhibits cyclophilin to reduce hepatic inflammation and fibrosis, which, in turn, could improve liver function and reduce portal‐systemic shunting. Since HepQuant quantifies liver function and portal‐systemic shunting, it was used to measure the hepatic effects of rencofilstat treatment of MASH with advanced fibrosis.MethodsSeventy subjects with suspected ≥ F3 MASH, defined from liver biopsy or AGILE 3+ ≥ 0.53, were randomised to rencofilstat 75 mg/d (n = 24), 150 mg/d (n = 23) or 225 mg/d (n = 23), and tested by HepQuant at baseline, 60 and 120 days. The DuO version included oral dosing of d4‐cholate and two blood samples (20 and 60 min). DuO's disease severity index (DSI) and portal‐systemic shunting fraction (SHUNT%) were evaluated for changes from baseline at 60 and 120 days of rencofilstat treatment.ResultsAcross all subjects, there was a significant decrease in SHUNT% both at Day 60 (−1.67%, p = 0.0156) and Day 120 (−1.55%, p = 0.0441). In the 225 mg rencofilstat arm, 56% of subjects (10/18) were responders by Day 120 (p = 0.0549), and their DSIs improved with a mean change of −1.61 (p = 0.0190). Across all treatment arms, subjects with DSI > 18.3 at baseline had the greatest improvement with treatment (ΔDSI = −2.59, p = 0.0053).ConclusionAlthough further studies are warranted, the decreases in DSI and SHUNT% suggest that rencofilstat 225 mg/d improves hepatic function and portal‐systemic shunting. HepQuant DuO is simple to administer, well‐tolerated and a useful tool for detecting the hepatic effects of treatment.Trial RegistrationThe study was registered at ClinicalTrials.gov, NCT05461105
Puccinia striiformis Effector PNPi Suppresses TaIAA14 Expression to Inhibit Host Cell Death Response
Authors: Wang Huiyutang , Gao Xue , Kong Yixi , Jia Zhiqiang , Qiao Liang , Yang Baoju 
Published: February 2025

ABSTRACTFungal pathogens secrete effectors that suppress the hypersensitive response (HR) of the host, characterised by programmed cell death, facilitating colonisation. However, how effectors manipulate host cell death remains poorly understood. In this study, we discovered that the Puccinia striiformis effector PNPi (Puccinia NPR1 interactor) suppressed BAX‐induced cell death in Nicotiana benthamiana. This virulence was mediated by the FtsN domain of PNPi, and an enhanced suppression effect was observed when Ser129 was mutated into arginine. Further RNA‐sequencing analysis revealed that auxin signalling was disturbed, with the auxin‐responsive protein IAA29‐like (NbIAA29) being downregulated during cell death suppression by PNPi. Exogenous application of auxins alleviated cell death suppression in N. benthamiana. Silencing NbIAA29 enhanced the PNPi‐induced suppression; however, this effect was reduced in NbIAA29‐silenced plants pretreated with auxins. Additionally, we confirmed the in vivo interaction between PNPi and TaIAA14, which is the homologous gene of NbIAA29 in wheat. Knocking down TaIAA14 through virus‐induced gene silencing significantly increased the fungal development and reduced wheat cell death response. Overall, these results indicate that the P. striiformis effector PNPi suppresses the cell death response by targeting TaIAA14 to facilitate infection, advancing our understanding of how P. striiformis effectors manipulate host immunity and providing a theoretical basis for new strategies of sustainable disease control.
A Rare Case of Intraosseous Mucoepidermoid Carcinoma of the Left Hemi‐Mandible, Masquerading as an Odontogenic Tumour
Authors: Marston Duncan , Higgans Rebecca Schembri , Farrugia Eric , Khurram Syed Ali 
Published: February 2025

ABSTRACTIntroductionPrimary intraosseous mucoepidermoid carcinoma (MEC) of the jaws is a vanishingly rare entity, accounting for 2%–3% of all MEC diagnoses. Albeit its low incidence, intraosseous mucoepidermoid carcinoma is the commonest and most well recognised intraosseous salivary gland neoplasm. These neoplasms typically present in middle‐aged adults, with a slight female predilection. Their incidence within the mandible is three times that of the maxilla, with the posterior body of the mandible and ascending ramus being the most common intraoral sites of involvement. Typically, they come to attention due to cortical expansion. Some lesions are entirely asymptomatic, with only a minority being associated with occasional pain or facial paralysis.Clinical HistoryA 75‐year‐old gentleman presented with an 8‐year history of non‐worsening, intermittent otalgia. CT neck, chest‐abdomen, and pelvis (NCAP) revealed the presence of a locally advanced, expansile, and destructive lesion within the left body and ramus of the mandible. The mandibular left wisdom tooth was extracted, and a biopsy of the lesion was performed.Histology and Laboratory InvestigationsHistologic examination revealed the presence of a cystic neoplasm comprised primarily of clear cells. Immunohistochemistry was performed and expert opinion sought. The diagnosis was ultimately achieved using molecular studies, which showed the presence of a MAML2 rearrangement, confirming the diagnosis of MEC.Surgical ManagementSurgical resection was carried out, with the patient undergoing a left hemi‐mandibulectomy and left‐sided supraomohyoid selective neck dissection. The mandibular defect was reconstructed using a mandibular reconstruction plate and right vastus and anterolateral (ALT) free flap. Following this, the patient received adjuvant radiotherapy and is under periodic review with no evidence of disease recurrence to date.ConclusionIntraosseous MEC may clinically, radiographically, and histologically mimic other disease entities more commonly encountered within the jaws given its unusual location and variable histologic presentation, making the diagnosis challenging. Identification of MAML2 rearrangement via molecular studies greatly facilitates the diagnostic process due to its high specificity for MEC. The overall prognosis is favourable with appropriate treatment, highlighting the importance of careful histologic evaluation and use of molecular studies.Trial Registration: Clinical Trial Number: 184/2023
“When I became older, I started having to manage that more myself”—Experiences of adolescents with food allergies: A qualitative study
Authors: O'Sullivan Meg , Curtin Margaret , Flynn Rachel , Trujillo Juan , O'Mahony James 
Published: February 2025

AbstractBackgroundIt's often caregivers or healthcare professionals' experiences that are studied in the field of allergy, but the adolescents' perspective is crucial to develop interventions that support them in areas they find most challenging. This study aims to explore adolescents' experience of managing food allergies, particularly how they navigate the transition from parental management to self‐management.MethodsThis is an interpretive descriptive qualitative study. Semi‐structured interviews were conducted with ten adolescents with food allergies aged 12–16 years. Reflexive thematic analysis was conducted. The Reflexive Thematic Analysis Reporting Guidelines were used.ResultsFour themes were generated, (1) belonging—seeing me, (2) not knowing (3) taking responsibility—“So I guess when I became older, I started having to manage that more myself” and (4) variation in coping strategies. These describe adolescents need for belonging, that their peers acknowledge their food allergies without making them feel like a burden. Adolescents understanding of essential food allergy information was lacking, with some unaware of this lack of knowledge. Adolescents were conscious of the need to take over responsibility from their parents, although this could be difficult. Finally, how adolescents coped with all these aspects of their food allergy could be seen as avoidant due to high anxiety, minimizing of risk, or adaptive, where adolescents are aware of and mitigate risks appropriately, without avoiding life experiences.ConclusionAdolescents find the transition of responsibility from their parents difficult. A trusted source of allergy information is required, aimed at adolescents, covering both physical allergy management and psychosocial content.
Strigolactones, ROS and ABA Regulate Systemic Salt‐Tolerance Priming Signals Between Dodder‐Connected Tobacco Plants
Authors: Zheng Xijie , Zhang Jingxiong , Zhao Man , Su Zhongxiang , Li Hongjing , Wu Jianqiang 
Published: February 2025

ABSTRACTThe parasitic plants dodders (Cuscuta spp., Convolvulaceae) can often simultaneously parasitize two or more neighbouring hosts, forming dodder‐connected plant clusters. In a dodder‐connected plant cluster, salt‐induced systemic priming signals are transferred from the salt‐stressed host (signal donor, SD) to the other host (signal receiver, SR) through dodder and prime the SR plants for enhanced salt tolerance, but what signalling pathways regulate the dodder‐mediated interplant priming signals remain unclear. In this study, using genetic analyses, we show that in dodder‐connected tobacco (Nicotiana tabacum) clusters, the strigolactone (SL), reactive oxygen species (ROS) and abscisic acid (ABA) pathway in the SD plants negatively control the salt stress‐induced systemic signals from SD to SR plants. Transcriptome data suggested that the salt‐induced systemic signals regulated by SLs in the SD plants may also affect the ABA and ROS signalling pathway in the SR plants. Quantification of the ABA and H2O2 contents in the SD plants suggested that the SL and ROS signalling likely converge on the ABA pathway to regulate the priming signals. This study reveals the important regulatory roles of phytohormones and ROS in dodder‐mediated interplant communications and provides new insight into systemic signalling during salt stress adaptation in individual plants.
Patient Perspectives on Clinician Support When Pursuing Permanent Contraception in the United States
Authors: Bullington Brooke W. , Lyleroehr Madison , Berg Kristen A. , White Kari , Boozer Margaret , Serna Tania , Miller Emily S. , Bailit Jennifer L. , Arora Kavita Shah 
Published: February 2025

ABSTRACTBackgroundGiven the history of coercion in the provision of sterilization, it is important that patients who desire permanent contraception receive patient‐centered care that respects their preferences. Recent literature examining the provision of postpartum permanent contraception has not explored whether patients who desire permanent contraception feel supported by their clinical teams.MethodsWe interviewed patients from four medical centers around the United States with a documented desire for postpartum permanent contraception. We audio‐recorded, transcribed, and analyzed interviews using rapid qualitative methods and thematic content analysis.ResultsOf the 81 patients interviewed, most (n = 64) felt supported by their clinician throughout their prenatal care and delivery hospitalization. Seventeen patients shared stories of feeling unsupported. Patients recalled feeling dismissed when they initiated conversations about permanent contraception. Additionally, they felt they had received incomplete counseling on permanent contraception and felt discouraged from getting the procedure during prenatal care encounters. During delivery hospitalization, patients discussed not being informed about barriers to permanent contraception as they surfaced, facing lack of prioritization of the procedure by clinicians, recognizing communications errors among the clinical team, and feeling pressured to undergo or not undergo permanent contraception.ConclusionMost patients felt supported by their clinicians throughout permanent contraception decision‐making and provision. Patients who did not feel supported reported a spectrum of experiences ranging from rushed appointments, perceived clinician bias in counseling, and communications barriers to the provision of permanent contraception after delivery. Patient‐centered care that prioritizes patient experiences, values, and desires is necessary to ensure that all people can achieve their reproductive goals.
The Impact of Disgusting Sounds on Pupil Diameter of Misophonic and Non‐Misophonic Listeners
Authors: Oszczapinska Urszula , Park Sungjoon , Qiu Yuqi , Nance Bridget , Julien Megan , Heller Laurie M. 
Published: February 2025

ABSTRACTEveryday sounds can elicit a range of emotional and physiological responses. For individuals with misophonia, some sounds can produce strong feelings of disgust, annoyance, and anger, often accompanied by increased perspiration and heart rate. Presently, methods of diagnosing misophonia rely on clinical interviews and self‐assessment scales. Coupling these subjective measures with an objective, physiological method like pupillometry may lead to improved understanding of misophonia and inform efficacy of treatments. Previous studies show that both unpleasant and pleasant sounds increase pupil diameter (Partala and Surakka 2003; Nakakoga et al. 2020); however, these have not compared pupil responses to disgust versus other emotions. Thus, we asked whether the pupil dilation to auditorily disgusting stimuli would be differentiable from other emotional sounds. In our listening task, we monitored pupil size changes while participants listened to positive and negative emotional sounds from the IADS database (Bradley and Lang 2007) along with “triggers” known to be especially aversive to misophonics. Participants reported the intensity of their emotional reactions (e.g., disgust, annoyance, happiness, fear) as well as valence and arousal. Misophonic listeners reported greater intensity of emotions associated with triggers (disgust, anger, and annoyance) as well as for fear. For all listeners, there was a positive association between changes in pupil diameter and emotion intensity. Overall, misophonics had greater pupil dilation than non‐misophonics, but after equating for emotion category of the sounds, misophonic pupil dilation was larger only for trigger sounds. Thus, pupillometry can differentiate misophonic and non‐misophonic listeners based on responses to everyday sounds evoking disgust.
Establishment and maintenance of embryogenic cell fate during microspore embryogenesis
Authors: Siemons Charlotte , Jonkers Sven , Vlieg Redmar Cornelis , Corral‐Martínez Patricia , van Noort John , Boutilier Kim 
Published: February 2025

SUMMARYMicrospore embryogenesis is a type of in vitro totipotency in which the immature male gametophyte (pollen) develops into a haploid embryo after an abiotic stress treatment. In Brassica napus, heat‐stress treatment of male gametophytes induces the development of different types of multicellular embryogenic structures, each with different cellular characteristics and the capacity to form a differentiated embryo. The origin and early development of these different embryogenic structures have not been determined. We used two‐photon excitation fluorescence microscopy and time‐lapse imaging of cells expressing either a LEAFY COTYLEDON1 (LEC1) embryo identity reporter or a DR5v2 auxin response reporter to follow the development of embryogenic structures starting at the single‐ to few‐cell stage. We show for the first time that the developmental fate of embryogenic structures is defined by the symmetry of the first embryogenic division and that the division plane also predicts the timing of subsequent pollen wall (exine) rupture: suspensorless embryos develop after a symmetric division and undergo late exine rupture, while suspensor‐bearing embryos and embryogenic callus develop after an asymmetric division and undergo early exine rupture. Live imaging also captured previously unknown dynamic LEC1 and DR5v2 expression patterns that are associated with changes in exine integrity. This study highlights the developmental plasticity of cultured pollen and uncovers new roles for the first embryogenic cell division plane and the exine in defining and maintaining cell fate during microspore embryogenesis.