bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excellent outcome of stem cell transplantation for sickle cell disease
Authors: Vallée Tanja , Schmid Irene , Gloning Lisa , Bacova Martina , Ahrens Jutta , Feuchtinger Tobias , Klein Christoph , Gaertner Vincent D. , Albert Michael H. 
Published: September 2023

AbstractMany sickle cell disease (SCD) patients lack matched family donors (MFD) or matched unrelated donors (MUD), implying haploidentical donors (MMFD) as a logical donor choice. We used a reduced toxicity protocol for all donor types. We included 31 patients (2–22 years) with MFD (n = 15), MMFD (10), or MUD (6) HSCT and conditioning with alemtuzumab/ATG, thiotepa, fludarabine and treosulfan, and post-transplant cyclophosphamide for MMFD. After the initial six patients, treosulfan was replaced by targeted busulfan (AUC 65–75 ng*h/ml). After a median follow-up of 26 months (6–123), all patients are alive and off immunosuppression. Two MMFD patients experienced secondary graft failure with recurrence of SCD, both after treosulfan conditioning. Neither acute GVHD ≥ °III nor moderate/severe chronic GVHD was observed. The disease-free, severe GVHD-free survival was 100%, 100%, and 80% in the MFD, MUD, and MMFD groups, respectively (p = 0.106). There was a higher rate of virus reactivation in MMFD (100%) and MUD (83%) compared to MFD (40%; p = 0.005), but not of viral disease (20% vs 33% vs 13%; p = 0.576). Six patients had treosulfan-based conditioning, two of whom experienced graft failure (33%), compared to 0/25 (0%) after busulfan-based conditioning (p = 0.032). Donor chimerism was ≥ 80% in 28/31 patients (90%) at last follow-up. Reduced toxicity myeloablative conditioning resulted in excellent overall survival, negligible GVHD, and low toxicity among all donor groups in pediatric and young adult patients with SCD.
Angiography-based hemodynamic features predict recurrent ischemic events after angioplasty and stenting of intracranial vertebrobasilar atherosclerotic stenosis
Authors: Huang Kangmo , Yao Weihe , Zha Mingming , Qin Shanmei , Li Yingle , Xu Yan , Liu Rui , Ye Ruidong , Han Yunfei , Zhu Wusheng , Teng Zhongzhao , Du Juan , Liu Xinfeng 
Published: September 2023

Abstract
Objectives
To assess the predictive value of hemodynamic features for stroke relapse in patients with intracranial vertebrobasilar atherosclerotic stenosis treated with percutaneous transluminal angioplasty and stenting (PTAS) using quantitative digital subtraction angiography (q-DSA).

Methods
In this retrospective longitudinal study, patients with intracranial vertebrobasilar atherosclerotic stenosis and who underwent PTAS treatment between January 2012 and May 2020 were enrolled. The q-DSA assessment was performed before and after PTAS. ROIs 1–4 were placed along the vertebral artery, proximal and distal basilar artery, and posterior cerebral artery; ROIs 5–8 were in 5 mm and 10 mm proximal and distal to the lesion, respectively. Relative time to peak (rTTP) was defined as the difference in TTP between ROIs. Cox regression analyses were performed to determine risk factors for recurrent stroke.

Results
A total of 137 patients (mean age, 62 years ± 10 [standard deviation], 83.2% males) were included, and 26 (19.0%) patients had stroke relapse during follow-up (median time of 42.6 months [interquartile range, 19.7–60.7]). Preprocedural rTTP4-1 (adjusted hazard ratio (HR) = 2.270; 95% CI 1.371–3.758; p = 0.001) and preprocedural rTTP8-5 (adjusted HR = 0.240; 95% CI 0.088–0.658; p = 0.006) were independently associated with the recurrent stroke. These hemodynamic parameters provided an incremental prognostic value for stroke relapse (AUC, 0.817 [0.704–0.931]; the net reclassification index, 0.431 [0.057–0.625]; and the integrated discrimination index, 0.140 [0.035–0.292]).

Conclusions
In patients with intracranial vertebrobasilar atherosclerosis treated with PTAS, preprocedural prolonged TTP of the target vessel and shortened trans-stenotic TTP difference were associated with stroke relapse. Q-DSA-defined hemodynamic parameters provided incremental predictive value over conventional parameters for stroke recurrence.

Clinical relevance statement
Quantitative DSA analysis enables intuitive observation and semi-quantitative evaluation of peri-therapeutic cerebral blood flow. More importantly, quantitative DSA–defined hemodynamic parameters have the potential for risk stratification of patients with intracranial atherosclerotic stenosis.

Key Points

Semi-quantitative angiography-based parameters can reflect pre- and postprocedural subtle changes in blood flow in patients with intracranial atherosclerotic stenosis.

Although angioplasty procedures can significantly improve blood flow status, patients with more restricted baseline blood flow still show a higher risk of stroke recurrence.

Angiography-based hemodynamic features possess prognostic value and can serve as clinical markers to assess stroke risk of patients with intracranial atherosclerotic stenosis.
Crop cultivation in the Talayotic settlement of Son Fornés (Mallorca, Spain): agricultural practices on the western Mediterranean islands in the first millennium bce
Authors: Stika Hans-Peter , Neugebauer Aleta , Rihuete-Herrada Cristina , Risch Roberto , Micó Rafael , Voltas Jordi , Amengual Paula , Gelabert Lara , Lull Vicente 
Published: September 2023

AbstractThe Balearic Islands were colonised around the transition from the Chalcolithic to the Bronze Age, not earlier than 2300 cal bce and certainly much later than any central or eastern Mediterranean islands. The number of archaeobotanical records is low and consists mainly of cereals and a few pulses. We present here new results of our long-term study of Son Fornés, an archaeological site on Mallorca which was occupied since the beginning of the Iron Age Talayotic period (~ 850 cal bce) and until Roman times (123 bce onwards), in the Balearic Islands. In the Talayotic period of Son Fornés Hordeum vulgare var. vulgare (hulled barley) and Triticum aestivum/durum/turgidum (free-threshing wheat) were the main cereals grown and Vicia faba (broad bean) was the main pulse, while Avena sp. (oats) is considered to have been a weed but was nonetheless consumed and was probably in an early phase of being domesticated. For the subsequent post-Talayotic (ca. 550 − 250 bce), Classic I and Classic II, the Republican Roman occupation period (from 123 bce onwards) the databases are weak, displaying hulled barley as the main crop and broad bean as the main pulse. The archaeobotanical records of Ficus carica (fig), Olea europaea (olive) and Vitis vinifera (grapevine) represent wild or cultivated and domesticated forms. Prunus dulcis (almond) and Pinus pinea (stone pine) were found on Eivissa (Ibiza), pointing to a Phoenician introduction to the islands, while Phoenix dactylifera (date palm) and Castanea sativa (chestnut), found on Menorca, might have been brought in by the Romans. The number of crops being used on the Balearic Islands was limited when compared to sites of similar periods on the European mainland or the central and eastern Mediterranean islands. According to carbon isotope results of Δ13C, hulled barley grew under damper conditions than free-threshing wheat. The high δ15N values indicated that both crops were well-manured with animal dung during the entire occupation period.
Climatology of near-surface wind speed from observational, reanalysis and high-resolution regional climate model data over the Tibetan Plateau
Authors: Minola Lorenzo , Zhang Gangfeng , Ou Tinghai , Kukulies Julia , Curio Julia , Guijarro Jose A. , Deng Kaiqiang , Azorin-Molina Cesar , Shen Cheng , Pezzoli Alessandro , Chen Deliang 
Published: September 2023

AbstractAs near-surface wind speed plays a role in regulating surface evaporation and thus the hydrological cycle, it is crucial to explore its spatio-temporal characteristics. However, in-situ measurements are scarce over the Tibetan Plateau, limiting the understanding of wind speed climate across this high-elevation region. This study explores the climatology of near-surface wind speed over the Tibetan Plateau by using for the first time homogenized observations together with reanalysis products and regional climate model simulations. Measuring stations across the center and the west of the plateau are at higher elevations and display higher mean and standard deviation, confirming that wind speed increases with increasing altitude. By exploring wind characteristics with a focus on seasonal cycle through cluster analysis, three regions of distinct wind regimes can be identified: (1) the central Tibetan Plateau, characterized by high elevation; (2) the eastern and the peripheral areas of the plateau; and (3) the Qaidam basin, a topographic depression strongly influenced by the blocking effect of the surrounding mountainous terrain. Notably, the ERA5 reanalysis, with its improvements in horizontal, vertical, and temporal spacing, model physics and data assimilation, demonstrates closer agreement to the measured wind conditions than its predecessor ERA-Interim. It successfully reproduces the three identified wind regimes. However, the newest ERA5-Land product does not show improvements compared to ERA5, most likely because they share most of the parametrizations. Furthermore, the two dynamical downscalings of ERA5 analyzed here fail to capture the observed wind statistics and exhibit notable biases and discrepancies also when investigating the diurnal variations. Consequently, these high-resolution downscaling products do not show add value in reproducing the observed climatology of wind speed compared to ERA5 over the Tibetan Plateau.
Introducing a standardized assessment of patients’ interest in and usage of CAM in routine cancer care: chances and risks from patients’ and physicians’ point of view
Authors: Shalgouny M. , Bertz-Lepel J. , Fischer v. Weikersthal L. , Herbin J. , Meier-Höfig M. , Mücke R. , Rohe U. , Stauch T. , Stoll C. , Troeltzsch D. , Wittmann S. , Kurz O. , Naumann R. , Huebner J. 
Published: September 2023

Abstract
Background
Cancer patients often use complementary and alternative medicine (CAM), however, standardized assessment in clinical routine is missing. The aim of this study was to evaluate a screening questionnaire on CAM usage that was published in the S3 Guideline Complementary Medicine in the Treatment of Oncological Patients.

Methods
We developed a survey questionnaire to assess the practicability of the guideline questionnaire and communication on CAM between health care providers (HCPs) and patients. We collected 258 guideline questionnaires and 116 survey questionnaires from ten clinics and held twelve semi-structured interviews with HCPs.

Results
85% used at least one of the listed CAM methods, 54 participants (N = 77) never disclosed usage to a physician. The most frequently used CAM methods were physical activity (76.4%) and vitamin D (46.4%). 25.2% used at least one method, that was labeled risky by the guideline. 53.4% did not know of CAM’s risk of interactions and side effects. Introducing the guideline questionnaire in routine cancer care increased the rate of patients talking to an HCP regarding CAM significantly from 35.5 to 87.3%. The HCPs stated positive effects as an initiation of conversation, increased safety within CAM usage and patients feeling thankful and taken seriously. However, due to the limited amount of time available for discussions on CAM, generalized distribution to all patients was not feasible.

Conclusion
Institutions should focus on implementing standard procedures and resources that help HCPs discuss CAM on a regular basis. HCPs should meet the patient’s demands for CAM counseling and make sure they are equipped professionally.
Delay for cholecystectomy after common bile duct clearance with ERCP is just running after recurrent biliary event
Authors: Bergeron Eric , Doyon Théo , Manière Thibaut , Désilets Étienne 
Published: September 2023

Abstract
Background
Gallstone disease will affect 15% of the adult population with concomitant common bile duct stone (CBDS) occurring in up to 30%. Endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay of management for removal of CBDS, as cholecystectomy for the prevention of recurrent biliary event (RBE). RBE occurs in up to 47% if cholecystectomy is not done. The goal of this study was to evaluate the timing of occurrence of RBE after common bile duct clearance with ERCP and associated outcomes.

Methods
The records of all patients who underwent ERCP for gallstone disease followed by cholecystectomy, in a single center from 2010 to 2022, were reviewed. All RBE were identified. Actuarial incidence of RBE was built. Patients with and without RBE were compared.

Results
The study population is composed of 529 patients. Mean age was 58.0 (18–95). There were 221 RBE in 151 patients (28.5%), 39/151 (25.8%) having more than one episode. The most frequent RBE was acute cholecystitis (n = 104) followed by recurrent CBDS (n = 95). Median time for first RBE was 34 days. Actuarial incidence of RBE started from 2.5% at 7 days to reach 53.3% at 1 year. Incidence-rate of RBE was 2.9 per 100 person-months. Patients with RBE had significant longer hospitalisation time (11.7 vs 6.4 days; P < 0.0001), longer operative time (66 vs 48 min; P < 0.0001), longer postoperative stay (2.9 vs 0.9 days; P < 0.0001), higher open surgery rate (7.9% vs 1.3%; P < 0.0001), and more complicated pathology (23.8% vs 5.8%; P < 0.0001) and cholecystitis (64.2% vs 25.9%; P < 0.0001) as final diagnoses.

Conclusions
RBE occurred in 28.5% of the subjects at a median time of 34 days, with an incidence of 2.5% as early as 1 week. Cholecystectomy should be done preferably within 7 days after common bile duct clearance in order to prevent RBE and adverse outcomes.
The effects of warm weather on children’s outdoor heat stress and physical activity in a preschool yard in Gothenburg, Sweden
Authors: Wallenberg Nils , Lindberg Fredrik , Thorsson Sofia , Jungmalm Jonatan , Fröberg Andreas , Raustorp Anders , Rayner David 
Published: September 2023

AbstractHot weather conditions can have negative impacts on the thermal comfort and physical activity of vulnerable groups such as children. The aim of this study is to analyze the effects of warm weather on 5-year-old children’s thermal comfort and physical activity in a preschool yard in Gothenburg, Sweden. In situ measurements were conducted for 1–1.5 h in the early afternoon on 8 days in May, June, and August of 2022. The thermal comfort and physical activity was estimated with GPS-tracks, heart rate monitors, and step counts and compared to observed weather conditions. Results show that physical activity decreases under warmer weather conditions, depicted by a decrease in distance moved, step counts, and highest registered pulse. Moreover, on warm days, the children avoid sunlit areas. For 50% or more of the time spent in sunlit areas, the children are exposed to cautious levels of heat. In shaded areas, on the other hand, the children are less exposed, with five out of 8 days having 50% or more of the time at neutral levels. The study demonstrates the importance of access to shaded areas in preschool yards where children can continue their active play while simultaneously maintaining a safe thermal status.
Health-related quality of life 2 years after pedicle subtraction osteotomy for sagittal imbalance: a single-center experience of 65 patients
Authors: Girod Pierre-Pascal , Lener Sara , Kögl Nikolaus , Hartmann Sebastian , Abramovic Anto , Krismer Laura , Santer Markus , Ortler Martin , Thomé Claudius 
Published: September 2023

Abstract
Purpose
Pedicle subtraction osteotomy (PSO) as an invasive procedure with high reoperation and complication rates in an often elderly population has often been questioned. The purpose of our study was to evaluate the impact of PSO for sagittal imbalance (SI) on patient-reported outcomes including self-reported satisfaction and health-related quality of life 2 years postoperatively.

Methods
Consecutive patients who underwent correction of their spinal deformity by thoracolumbar PSO were assessed using self-reporting questionnaires 2 years postoperatively. Outcome was measured by visual analogue scale (VAS) for back and leg pain, Oswestry Disability Index (ODI), and EQ-5D scores. Additionally, a Patient Satisfaction Index (PSI) rated in four grades (A: very satisfied to D: not satisfied), walking range, and the Timed Up and Go (TUG) Test were evaluated.

Results
Sixty-five patients were included, and each parameter was assessed preoperatively and 24 months postoperatively. The intervention led to significant improvements in back pain (8.1 ± 1.2 vs. 2.9 ± 1.9; p < 0.001), as well as ODI scores (57.7 ± 13.9 vs. 32.6 ± 18.9; p < 0.001), walking range (589 ± 1676 m vs. 3265 ± 3405 m; p < 0.001), and TUG (19.2 s vs. 9.7 s; p < 0.05). 90.7% of patients (n = 59/65) reported a PSI grade “A” or “B” 24 months postoperatively.

Conclusion
Patient satisfaction 24 months after PSO for SI is high. Quality of life improved significantly by restoring sagittal balance.
Post-extraction volumetric analysis of alveolar ridge contour using subepithelial connective tissue graft in esthetic zone: a randomized controlled clinical trial
Authors: Gamal Nourhan , Shemais Nesma , Al-Nawawy Marwa , Ghallab Noha A. 
Published: September 2023

Abstract
Objectives
The aim of this randomized clinical trial was to assess the alveolar ridge contour after soft tissue augmentation using subepithelial connective tissue graft (SCTG) buccal to fresh extraction sockets in patients with thin buccal bone, versus minimally-traumatic extraction followed by spontaneous healing solely.

Materials and methods
Forty non-restorable maxillary teeth in the esthetic zone were randomly assigned into two groups: minimally-traumatic extraction with SCTG (test) and minimally-traumatic extraction followed by spontaneous healing (control). The outcomes assessed included linear volumetric change of buccal soft tissue contour, vertical tissue loss, gingival thickness (GT), and interdental papilla (IDP) height after 6 months.

Results
The SCTG group showed a significant improvement (P < 0.001) in all outcomes after 6 months. The SCTG group showed a statistically significant (P < 0.001) gain in the buccal soft tissue volumetric change compared to the control group. The SCTG group showed a statistically significant increase in GT (P < 0.001) and IDP height (P < 0.05) after 6 months compared to the control group.

Conclusions
The use of SCTG buccal to extraction sockets in the anterior maxilla might be considered as a predictable approach for preserving the alveolar ridge contour.

Clinical relevance
SCTG buccal to extraction sockets might counteract post-extraction hard and soft tissue alterations in the esthetic zone.
Can local explanation techniques explain linear additive models?
Authors: Rahnama Amir Hossein Akhavan , Bütepage Judith , Geurts Pierre , Boström Henrik 
Published: September 2023

AbstractLocal model-agnostic additive explanation techniques decompose the predicted output of a black-box model into additive feature importance scores. Questions have been raised about the accuracy of the produced local additive explanations. We investigate this by studying whether some of the most popular explanation techniques can accurately explain the decisions of linear additive models. We show that even though the explanations generated by these techniques are linear additives, they can fail to provide accurate explanations when explaining linear additive models. In the experiments, we measure the accuracy of additive explanations, as produced by, e.g., LIME and SHAP, along with the non-additive explanations of Local Permutation Importance (LPI) when explaining Linear and Logistic Regression and Gaussian naive Bayes models over 40 tabular datasets. We also investigate the degree to which different factors, such as the number of numerical or categorical or correlated features, the predictive performance of the black-box model, explanation sample size, similarity metric, and the pre-processing technique used on the dataset can directly affect the accuracy of local explanations.
Leaf physiology and histopathology of the interaction between the opportunistic phytopathogen Fusarium equiseti and Gossypium hirsutum plants
Authors: de Souza Marques Matheus Mendonça , Vitorino Luciana Cristina , Rosa Márcio , Dário Bruno Matheus Mendes , Silva Fabiano Guimarães , Bessa Layara Alexandre 
Published: September 2023

AbstractFungal diseases constitute a major challenge in the cultivation of the world's most important textile plant, cotton. Opportunistic fungi attack plants and promote physiological alterations and tissue damage, thereby causing losses in productivity. Herein, the hypothesis that Gossypium hirsutum L. plants are physiologically affected, depending on the phenological stage and site of infection (root system or leaf), when affected by the opportunistic phytopathogen Fusarium equiseti was tested. To this end, the photosynthetic pigment production, gas exchange, chlorophyll a fluorescence, and histopathological mechanisms involved in the plant-phytopathogen interaction were evaluated. This study aimed to diagnose the most aggressive route of infection by comparing infection via root with infection via the leaf, and to identify the developmental stage with the highest susceptibility by comparing different phenological stages. Cotton plants show metabolic losses at the maturation stage, resulting in low photosynthetic pigment concentrations, low photosynthetic rates, and photochemical stress. However, when infected by F. equiseti in the root region, the photosynthesis and photochemistry of these plants are more affected than plants inoculated in the leaf region. Low net photosynthesis (A) and water use efficiency (WUE) rates, but high light absorption flux (ABS/RC) and energy dissipation flux (DI0/RC) values were observed. Regardless of the phenological stage, the presence of F. equiseti in the roots of cotton plants caused high transpiratory rates in the plants, suggesting non-stomatic water loss and photochemical damage. In contrast, non-inoculated plants produced more photosynthetic pigments and showed higher WUE and photochemical efficiency, as indicated by the high PIABS values. Leaf histopathology assessment revealed more fragile regions of the epidermis, such as the contact region between the guard cells and adjacent epidermal cells, as well as the basal region of glandular trichomes as important access routes for F. equiseti to the inner leaf layers at all developmental stages. This study confirmed that the root colonization of cotton plants with F. equiseti can more intensely impact the physiological quality of the plants, regardless of the developmental stage.