bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic factors and impact of fertility-sparing surgery in women with FIGO stage I clear cell ovarian carcinoma: a Surveillance, Epidemiology, and End Results (SEER) analysis
Authors: Tang Xinyue , Wang Tian , Hu Yuanjing 
Published: July 2023

Abstract
Purpose: This study aimed to investigate prognostic factors of stage I ovarian clear cell carcinoma (OCCC), as well as the impact of fertility-sparing surgery (FSS) on the oncologic outcomes of young patients with stage I ovarian clear cell carcinoma.
Methods: The Surveillance, Epidemiology, and End Results (SEER) database was accessed and data of patients with primary diagnosed stage I OCCC from 2010 to 2019 was extracted. Univariate and multivariate Cox regression analyses were employed to identify independent predictors associated with survival in women with stage I OCCC. Survival analysis was assessed with the Kaplan–Meier method, and the results were compared with the log-rank test.
Results: A total of 1,556 patients met the inclusion criteria. Median age was 56 years. The majority were unilateral (96.9%) and white (75.2%).1,213(78.0%) patients were treated with chemotherapy, and 1,271(81.7%) patients received Lymph node dissection. Age of diagnosis, race, and substage were independently associated with OS, while race, substage and months from diagnosis to treatment were independently associated with CSS. For OCCCs with stage IA, fertility-sparing surgery was not associated with a worse overall or cancer-specific survival. Chemotherapy and lymph node resection were not associated with survival outcomes of patients with stage IA who underwent FSS.
Conclusions:Overall LN dissection and chemotherapy did not significantly impact OS and CSS of women with FIGO stage I OCCC. Fertility-sparing surgery did not affect survival of stage IA OCCCs. Chemotherapy and LN dissection were not associated with survival outcome of patients with stage IA who underwent FSS.
Four-Period Integration Oversampling Method (4PIOM) for Hardware-in-the-Loop power converters with complementary switches
Authors: Zamiri Elyas , Sanchez Alberto , de Castro Angel 
Published: July 2023

Abstract
This paper addresses aliasing oscillations encountered in hardware-in-the-loop (HIL) simulation caused by inaccurate duty cycle detection in high-frequency power electronic applications. Oversampling has been commonly used as a solution to detect switching events more accurately. Traditional oversampling methods use the extra information obtained by oversampling the inputs for further computations to enhance the precision of the simulation. However, these techniques increase the complexity of the model since they take into account several switch states during each simulation step. To mitigate these complexities, the Integration Oversampling Method (IOM) is introduced as a recent alternative with minimum impact on the model complexity. IOM provides a modified switching pattern that effectively prevents aliasing oscillations while maintaining a single switch-state for each simulation step. It can be implemented as an independent block between the controller and the HIL model, so it keeps the HIL model unchanged. This study highlights the limitations detected in applying IOM to the models with complementary switches, including possible undesired short circuits. To overcome these limitations, a novel oversampling method called 4PIOM is presented. 4PIOM further enhances the IOM algorithm by reducing the simulation step and sampling period. The validity of the new method is demonstrated by comparison with previous proposals and also with the same model without any oversampling. Both experimental and MATLAB simulation results prove its superior performance in attenuating the aliasing oscillations and improving the quality of the simulation.
Flexural Behavior of Laminated Wood Beams Strengthened with Novel Hybrid Composite Systems: An experimental study
Authors: OZDEMIR Mehmet Faruk , Maras Muslum Murat , YURTSEVEN Hasan Basri 
Published: July 2023

Abstract
In this study, it was aimed to improve the mechanical properties of laminated timber beams by using NovelHybrid Systems (Carbon Fiber Reinforced Polymer and Wire Rope). Reducing the cross-sectional area of the beam is important for the strength conditions required in large span systems with structural laminated wood material. Within the scope of this study, it is foreseen that the use of wood, which is an environmentally friendly and sustainable building element, will be made more economical and safe, instead of reinforced concrete and steel elements currently used to pass wide openings. Structural behavior of hybrid reinforced laminated timber beams was determined under the loading system.Experimental findings show that normal laminated timber beam (0N) has a maximum load of 14 kN and a deflection of 36 mm.On the other hand, the highest increase in the values of laminated beams reinforced with steel ropes was obtained with the (2N) reinforcement, with a maximum load of 38 kN and a displacement of 137mm.In this way, a load increase of 168% and a displacement increase of 275% compared to the reference sample were obtained. Since the steel rope-reinforced samples absorb the load, crack formation and transfer to the upper layers are prevented.3F beam specimen reinforced with CFRP and steel ropes obtained maximum load of 28 kN and a displacement of 152 mm. Compared to the reference sample, a load increase of 92% and a displacement increase of 14% were obtained. Consequently, the fabrics placed between the layers with CFRP prevented crack development and provided a significant interlayer connection.It has been observed that the fiber composite-reinforced wooden beams increase the load bearing capacity by more than 50% and exhibit a ductile behavior.The carbon fabrics placed between the laminated wooden beams with the innovative reinforcement system will not both disrupt the aesthetics and will reduce the effect of earthquake forces, and significant reductions can be achieved in the sections.
Nucleosome Positioning Events and Probability Model Created with Probability Theory Application in a Human DNA Sequence
Authors: Cherif Brahim , Cherif Salah 
Published: July 2023

AbstractThe histone code hypothesis predicts that histone modifications control chromatin processes such as gene expression, but their consequences are not highly predictable. Accordingly, nucleosome positioning is suggested to be a code that dictates distinct epigenetic states. The aim of this work was to mathematically model nucleosome positioning as a first step toward testing the nucleosome code hypothesis. Nucleosome positioning was predicted with NXSensor software in a human DNA sequence. Probability theory was applied to model nucleosome positioning; positioning events and probabilities were modeled, and then probabilities were calculated. Nucleosome positioning events were proportional to nucleosome occupancy, but they were not proportional to positioning probabilities. Based on our results, we proposed a general nucleosome positioning model, and we searched for evidence of the model in the literature. The proposed model can be applied to test the association between events and experimental data of both positioning and gene expression and cell states events to validate or reject the nucleosome code hypothesis.
Long-time traffic speed prediction model based on XGBoost
Authors: Shen Zhou (Eric) 
Published: July 2023

Abstract
Accurate traffic speed prediction plays a crucial role in traffic management and transportation planning. In this paper, we propose a long-time traffic speed prediction model based on XGBoost, a powerful ensemble learning algorithm. Our method addresses the challenge of predicting traffic speed over extended time horizons by incorporating spatial and temporal dependencies, feature selection, and interpretability analysis. We conduct experiments on a real-world traffic dataset and compare our results with state-of-the-art methods. The experimental results demonstrate the superior performance of our proposed model in terms of mean absolute error (MAE) and root mean square error (RMSE). The incorporation of spatial and temporal dependencies, coupled with the interpretability analysis provided by XGBoost, enables us to capture complex traffic patterns and gain insights into the factors influencing traffic speed. Our research contributes to the field of traffic prediction by offering a robust and interpretable solution that can aid in traffic management, urban planning, and intelligent transportation systems.
1,3,4-Oxadiazole: An Emerging Scaffold to Inhibit the Thymidine Phosphorylase as an Anticancer Agent
Authors: Murmu Anjali , Banjare Purusottam , Matore Balaji Wamanrao , Roy Partha Pratim , Singh Jagadish 
Published: July 2023

:
Thymidine phosphorylase (TP), also referred to as "platelet-derived endothelial
cell growth factor" is crucial to the pyrimidine salvage pathway. TP reversibly transforms
thymidine into thymine and 2-deoxy-D-ribose-1-phosphate (dRib-1-P), which further degraded
to 2-Deoxy-D-ribose (2DDR), which has both angiogenic and chemotactic activity.
In several types of human cancer such as breast and colorectal malignancies, TP is
abundantly expressed in response to biological disturbances like hypoxia, acidosis, chemotherapy,
and radiation therapy. TP overexpression is highly associated with angiogenic
factors such as vascular endothelial growth factor (VEGF), interleukins (ILs), matrix metalloproteases
(MMPs), etc., which accelerate tumorigenesis, invasion, metastasis, immune
response evasion, and resistant to apoptosis. Hence, TP is recognized as a key target for
the development of new anticancer drugs. Heterocycles are the primary structural element
of most chemotherapeutics. Even 75% of nitrogen-containing heterocyclic compounds are
contributing to the pharmaceutical world. To create the bioactive molecule, medicinal
chemists are concentrating on nitrogen-containing heterocyclic compounds such as pyrrole,
pyrrolidine, pyridine, imidazole, pyrimidines, pyrazole, indole, quinoline, oxadiazole,
benzimidazole, etc. The Oxadiazole motif stands out among all of them due to its
enormous significance in medicinal chemistry. The main thrust area of this review is to
explore the synthesis, SAR, and the significant role of 1,3,4-oxadiazole derivatives as a
TP inhibitor for their chemotherapeutic effects.
Miniaturized Polymeric Systems for the Intravaginal Gene Therapies: Recent
Update on Unconventional Delivery
Authors: Pandey Manisha , Ting Jocelyn Su Szhiou , Gorain Bapi , Jain Neha , Mayuren Jayashree 
Published: July 2023

Abstract:
The prevalence of vaginal infection is increasing among women, especially at reproductive age. For
proper eradication of infection, the effective concentration of a drug is required at the infection site. Therefore,
local delivery is recommended to exert a direct therapeutic effect at the site action that causes a reduction in
dose and side effects. The main focus of vaginal drug delivery is to enhance retention time and patient compliance.
The high recurrence rate of vaginal infection due to the lack of effective treatment strategies opens the
door for new therapeutic approaches. To combat these setbacks, intravaginal gene therapies have been investigated.
High attention has been gained by vaginal gene therapy, especially for sexually transmitted infection
treatment. Despite much research, no product is available in the market, although in vitro and preclinical data
support the vaginal route as an effective route for gene administration. The main focus of this review is to discuss
the recent advancement in miniaturized polymeric systems for intravaginal gene therapies to treat local infections.
An overview of different barriers to vaginal delivery and challenges of vaginal infection treatment are
also summarised.
Pictet-Spengler Synthesis of N-heteroaromatics Extended Porphyrins
Authors: Singh Dileep Kumar 
Published: July 2023

Background:
Porphyrins are highly conjugated heterocyclic compounds and are found as the backbone of many natural products such as heme and chlorophyll. To improve its biological and optical properties, the functionalization of porphyrin at its β- and meso-position has gained importance in recent years.

Objective:
The purpose of this review is to describe the Pictet-Spengler method for the incorporation of nitrogenous and biologically important heterocyclic scaffolds such as pyrrolo-/indolo[1,2-a]quinoxaline, pyrrolo[1,2-a]pyrazine, and quinoline at the β- and meso-positions of the porphyrins to increase π-conjugation and improve their biological, optical, and electrochemical properties.

Conclusion:
This review provides a comprehensive overview of the synthesis of N-heterocyclic ex-tended porphyrins and metalloporphyrins via a modified Pictet-Spengler approach. The synthesized porphyrins were found to be highly conjugated and exhibited improved photophysical properties com-pared to their parent analogues. Moreover, the review article provided a brief overview of the Pictet-Spengler procedure, including product yields, reaction conditions, photophysical properties of the syn-thesized products, and potential applications in a variety of fields.
Regulatory Role, Mechanism, and Metabolic Profile of BIOTIN in
Gene Expression
Authors: Wal Ankita , Sasmal Abhijit , Singh Riya , Yadav Princy , Singh Yogesh , Garg Vipin , Wal Pranay 
Published: July 2023

Abstract:
Biotin, a vitamin that is water-soluble, is part of the vitamin B complex and is required
by all living things, including humans. Biotin-dependent carboxylases are a prosthetic
group of enzymes, and biotin catalyzes essential processes in the production of fatty acids,
the breakdown of amino acids, and gluconeogenesis in eukaryotic cells. The role of biotin
as the prosthetic group of the four biotin-dependent carboxylases is well understood in
higher animals. Based on the roles of these carboxylases in metabolism, it was discovered
that biotin is required for cell survival, proliferation, and differentiation. Biotin appears to
play a role in cell function and has a spermatogenic impact. Biotin has been found to have a
direct impact on the transcription of important enzymes in glucose metabolism. Glucokinase
and phosphoenolpyruvate carboxykinase are glycolytic enzymes that biotin controls
(PEPCK). Biotin appears to be involved in gene control, which may explain some of its
functions regarding fetal development and cellular biology. According to investigations using
microarrays as well as other types of gene expression, biotin appears to affect the transcription
of genes encoding cytokines and their receptors, glucose metabolism genes, and
genes involved in cellular biotin homeostasis. A biotin shortage has a considerable effect on
gene expression in numerous tissues and cells, according to a microarray study. Biotin supplementation
affects the expression of several genes depending on the tissue, demonstrating
that gene expression differences reflect tissue function. Biotin affects energy, lipid, and glucose
metabolism, according to metabolite research, which has improved our understanding
of the biotin metabolic pathway. Using microarray and transcriptome analysis, this research
investigates the effect of biotin on gene expression.
Pengaruh Latihan Resistance Band Terhadap Kemampuan Pukulan Atlet Karate Junior Kabupaten Sarolangun
Authors: Akbar Ilham , Indrayana Boy , Hasibuan Mhd. Usni Zamzami 
Published: July 2023

Tujuan penelitian ini adalah untuk mengetahui pengaruh latihan resistance band terhadap kemampuan pukulan Atlet Karate Junior Kabupaten Sarolangun. Penelitian ini menggunakan metode eksperimen, dalam penelitian ini terdapat satu kelompok eksperimen yang sengaja diberikan perlakuan. Adapun rancangan penelitian ini menggunakan rancangan One Group Pretest-Postest Design. Sampel yang digunakan adalah Atlet Junior Karate yang berjumlah 20 orang diambil secara purposive sampel. Berdasarkan hasi analisis data diperoleh untuk tes awal dengan jumlah sampel 20 orang kemudian didapatkan jumlah nilai 1445 dengan rata-rata nilai 72.25, dan standar deviasi 8.03, sedangkan varian 64.41. Untuk data tes akhir dengan jumlah sampel 20 orang kemudian didapatkan jumlah nilai 1620, dengan rata-rata nilai 81 dan standar deviasi 7.18, sedangkan varian 51.58. Untuk uji normalitas Lo < Ltabel, maka data dari tes awal dan tes akhir memiliki distribusi data yang normal karena, untuk tesawal Lo (0.1789) < Ltabel (0.190), tes akhir Lo (0.1412) < Ltabel (0.190). Perbandingan harga antar t hitung dengan nilai presentil pada tabel distribusi – t, untuk taraf nyata α = 0,05 dengan derajat kebebasan (dk) = (n – 1) = 19 diperoleh t hitung (9.1998 ) > t tabel (1,7291). Ini berarti hipotesis Ha yang diterima dan Ho ditolak. Jadi dapat disimpulkan terdapat pengaruh latihan resistance band terhadap kemampuan pukulan atlet karate junior Kabupaten Sarolangun dengan t Hitung > t Tabel. Dapat di simpulkan bahwa terdapat pengaruh latihan resistance band terhadap kemampuan pukulan atlet karate junior Kabupaten Sarolangun.
Kata kunci: Resistance Band, Kemampuan Pukulan Atlet.
Analisis Tingkat Kebugaran Jasmani pada Siswa kelas X MAN 1 Tanjung Jabung Barat
Authors: Marsanda Putri , Kurniawan Alexander 
Published: July 2023

Berdasarkan permasalahan-permasalahan Setiap penelitian yang dikerjakan selalu memiliki tujuan akhir untuk memperoleh gambaran yang jelas dan bermanfaat bagi yang menggunakannya. Adapun tujuan dari penelitian ini adalah untuk mengetahui tingkat kebugaran jasmani pada siswa MAN 1 Tanjung Jabung Barat. Penelitian ini dilaksanakan di MAN 1 Tanjung Jabung Barat dengan subjek penelitian ini yaitu siswa kelas X. Jenis penelitian ini merupakan penelitian deskriptif kuantitatif, dalam penelitian ini diperoleh dari observasi, tes pengukuran menggunakan instrumen TKJI. Berdasarkan hasil penilitian diperoleh 0 siswa (0%) yang mempunyai tingkat kebugaran jasmani baik sekali, 2 siswa (2,82%) yang mempunyai tingkat kebugaran jasmani baik, 25 siswa (35,21%) yang mempunyai tingkat kebugaran jasmani sedang, 37 siswa (52,11%) yang mempunyai tingkat kebugaran jasmani kurang, dan 7 siswa (9,86%) yang mempunyai tingkat kebugaran jasmani kurang sekali. Hasil penelitan menunjukan bahwa tingkat kebugaran jasmani siswa putra kelas X MAN 1 Tanjung Jabung Barat mempunyai tingkat kebugaran jasmani dalam kategori kurang. Bagi siswa kelas X MAN 1 Tanjung Jabung Barat terkhususnya bagi siswa putra, diharapkan selalu memperhatikan dan menjaga kebugaran tubuhnya serta rutin melakukan aktivitas olahraga, dengan tujuan untuk membantu proses peningkatan kebugaran jasmani siswa..
Kata Kunci: Tes Kebugaran Jasmani Indonesia, siswa
Pengaruh Konsumsi Cafein Sebelum Latihan Terhadap Daya Tahan Cardiovescular Pemain PB. Siguntung Kabupaten Tebo
Authors: Moni Moni , Iqroni David 
Published: July 2023

Tujuan penelitian ini untuk mengetahui pengaruh konsumsi kafein sebelum latihan terhadap daya tahan Cardiovascular Pemain PB. Siguntung Kabupaten Tebo. Penelitian ini menggunakan metode eksperimen, dalam penelitian ini terdapat satu kelompok eksperimen yang sengaja diberi perlakuan. Penelitian ini dilaksanakan di PB. Siguntung Kabupaten Tebo. Berdasarkan hasil analisis data dengan jumlah sampel 5, mean 2,92, Standar Deviasi 1,67 dan thitung 3,93. Perbandingan harga antara t hitung dengan nilai presentil pada tabel distribusi – t, untuk taraf nyata α = 0,05 dengan derajat kebebasan (dk) = (n – 1) = 4 diperoleh t hitung (3,92) > t tabel (2,1318). Dapat disimpulkan bahwa terdapat pengaruh konsumsi kafein sebelum latihan terhadap daya tahan Cardiovascular Pemain PB. Siguntung Kabupaten Tebo
PENGARUH KONSENTRASI AKTIVATOR H3PO4 TERHADAP KARBON AKTIF AMPAS TEBU
Authors: Hasanah Hayatul , Sirait Ratni , Yusuf Lubis Ridwan 
Published: July 2023

Ampas tebu adalah sisa penggilingan tebu yang sebagian belum dimanfaatkan secara maksimal oleh masyarakat. Kurang lebih 50% ampas tebu yang diperoleh setiap pabrik gula dijadikan untuk bahan bakar boiler kemudian sisanya ditimbun sebgai buangan. Ampas tebu mempunyai kandungan karbon cukup tinggi sehingga bisa digunakan untuk bahan dasar karbon aktif. Dilakukan penelitian tentang pembuatan karbon aktif ampas tebu dengan menggunakan aktivator H3PO4. Metode penelitian yang dilakukan yaitu dengan metode eksperimen secara kuantitatif. Untuk mengetahui mutu karbon aktif dilakukan pengujian meliputi uji kadar air, kadar ZMM, kadar abu dan kadar karbon terikat. Serta diukur luas permukaannya dengan metode methylene blue serta karakterisasi dengan SEM dan FTIR. Luas permukaan terbesar diperoleh pada sampel yang teraktivasi H3PO4 5% yaitu 11,0893 m2/g. Hasil analisis SEM menunjukkan karbon aktif ampas tebu yang teraktivasi H3PO4 5% memiliki pori-pori lebih banyak dibandingkan karbon aktif yang teraktvasi H3PO4 0% dan 15%. Hasil penelitian FTIR menunjukkan terdapatnya gugus fungsi OH, N-H, C=C, C-H alkana, C-O, OH, C-H. Vaiasi karakteristik yang optimum pada karbon aktif ampas tebu terdapat pada sampel B yang memilki nilai kadar air, kadar ZMM, kadar abu dan kadar karbon terikat memenuhi SNI No 06-3730-1995 mengenai karbon aktif.
Kata Kunci: Karbon aktif, Ampas Tebu, H3PO4 , SEM, FTIR
ANALISIS NEUTRONIK KEKRITISAN TERAS REAKTOR NUSCALE BERBAHAN BAKAR DENGAN MENGGUNAKAN SOFTWARE OPENMC
Authors: Putri Canti Dwi , Monado Fiber , Ariani Menik 
Published: July 2023

[Title: Neutronic Analysis of the criticality level of the nuscale reactor core with fuel using the openMC software] This study analyzed the design of the NuScale reactor, which aims to determine the level of criticality by modeling the shape of the cell pin, assembly, and core with nuclear fuel in the form of uranium dioxide, which will be varied by changing the percentage of uranium-235 content as much as 0% to 7% by using monte carlo methods in OpenMC program code. This study was conducted to obtain the design of nuclear reactors as well as the calculation of the effective multiplication factor, fission reaction rate, and neutron flux distribution for two years of the combustion process (Burn-up). The result of the calculation for the effective multiplication factor and reaction rate states that the greater the percentage of enrichment in uranium-235, the greater the value of the resulting in both parameters. While the distribution of neutron flux produces the most significant value in the middle region or center of the fuel and is seen from the average value produced, and the smallest value is at the edge of the cell. The analysis of this NuScale reactor can later be used as a reference in preparing a safe and efficient reactor core.
Sistem Pemerintahan dan Politik Etis Belanda Serta Penerapannya di Provinsi Jambi
Authors: Ayu Wulandari Mustika , Nurdin Fatonah , Adiguna Richad Saputra 
Published: July 2023

Penelitian ini mengkaji tentang bagaimana system pemerintahan dan politik etis belanda serta penerapanya di provinsi jambi dengan maksud dan tujuan dapat menyajikan data yang valid dengan metode kuantitif. Dalam penelitian ini, metode yang di gunakan yaitu mengumpulkan sumber-sumber dan menuangkanya kembali dalam bentuk deskriptif naratif yang mudah di pahami. Latar belakang dari penelitian yang di buat ini adalah adanya perubahan system pemerintahan yang pernah terjadi di jambi yaitu dari system pemerintah kesultanan menjadi keresidenan akibat adanya pengaruh belanda yang pada saat itu mulai menguasai wilayah jambi. Sejak masuknya belanda ke jambi banyak system pemerintahan di jambi sendiri mengalami perubahan salah satunya yaitu dengan adanya politik etis dimana pada penerapannya juga membawa banyak dampak positif bagi penduduk masyarakat pribumi khususnya di jambi walaupun belanda memiliki tujuan lainya yaitu menjajah dan menguasai wilayah jambi.
Kata Kunci: Sistem Pemerintah dan Politik Etis