bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementación del POGIL (Process Oriented Guided Inquiry Learning) en las prácticas de laboratorio de fisiología en Medicina Veterinaria
Authors: Balaguera Quinche David Fernando , Gómez Duarte Leonardo , Balaguera Quinche Paula Andrea 
Published: August 2023

Se implementó la pedagogía POGIL (Process Oriented Guided Inquiry Learning) en los laboratorios prácticos de Fisiología dirigido a estudiantes de Medicina Veterinaria en la Universidad Nacional de Colombia. El objetivo consistió en explorar una alternativa educativa basada en el constructivismo diferente a la metodología tradicional compuesta por instrucciones “paso a paso”. Como herramientas para explorar esta implementación, se utilizó un test de pensamiento para evaluar las habilidades de pensamiento crítico en estudiantes, un formato de metacognición para evaluar el trabajo grupal, una encuesta estructurada para explorar el aporte del POGIL en varias habilidades académicas y un formato de “reflexión del aprendizaje” para visualizar las fortalezas y debilidades en aspectos teóricos y prácticos de los laboratorios en Fisiología. Como conclusión, en el estudiantado el POGIL promueve la memorización y el entendimiento de conceptos en Fisiología, aporta fortalezas académicas y promueve habilidades de dominio en su instrumentación, sin embargo, no se reflejó ningún aporte satisfactorio en el desempeño del trabajo grupal en este estudio.
¿Existen vínculos entre la racionalidad ambiental, el saber ambiental, el diálogo de saberes y la restauración ecológica? Aportes a la construcción de marcos teóricos para la recuperación de ambientes con fines educativos. Entrevista a Enrique Leff
Authors: Pérez Daniel Roberto 
Published: August 2023

¿Existen vínculos entre la racionalidad ambiental, el saber ambiental, el diálogo de saberes y la restauración ecológica? Aportes a la construcción de marcos teóricos para la recuperación de ambientes con fines educativos. Entrevista a Enrique Leff
DAUN SUKUN (ARTOCARPUS ALTILIS) SEBAGAI OBAT GANGGUAN GINJAL PADA TIKUS WISTAR YANG DIBERI CISPLASTIN
Authors: Suprasetya Edy 
Published: August 2023

Daun sukun (Artocarpus altilis (Park.) Fsb.) merupakan tanaman yang secara empiris dapatdigunakan untuk mengobati gangguan ginjal. Penelitian dilakukan untuk mengetahui efeknefroprotektif ekstrak etanol daun sukun daun sukun pada tikus putih jantan galur wistar yangdiinduksi dengan cisplastin terhadap parameter fungsi ginjal seperti BUN, Ureum dan KreatininPenelitian ekperimental menggunakan tikus putih jantan galur wistar 20 ekor, berat badan 150-250 g.Kelompok normal (+) diberi CMC-Na P.O. Kelompok kontrol (-)induksi cisplastin 60 mg/M2 I.P.Kelompok dosis I, II, III dengan EEDS50 mg/kgBB,100mg/kgBB dan 200mg/kgBB P.O. Pemberian
daun sukun pada ketiga kelompok dosis menunjukkan efek memperbaiki ginjal. Hasil uji Kruskall-Wallis didapat nilai p=0,009 (<0,05) BUN dan ureum, yang artinya terdapat perbedaan signifikan
pemberian ekstrak daun sukun dalam penurunan kadar BUN dan ureum. Pada kreatinin nilai p=0,134 >0,05 yang artinya tidak terdapat perbedaan yang signifikan untuk kadar kreatinin.
Uji Sifat Fisik Body Scrub dari Ekstrak Ubi Jalar Ungu ( Ipomoea batatas Lam )
Authors: Purwanti Ratih , Hanan Yumna Nadhia 
Published: August 2023

Body scrub adalah sediaan kosmetik yang digunakan untuk perawatan kulit. Ubijalar ungu mempunya kandungan antosianin yang tinggi sebagai antikanker, antioksidandan antihipertensi. Ubi jalar ungu memiliki beberapa kelebihan dibandingkan ubi warnalainnya, terutama dalam hal kandungan antosianin yang lebih tinggi, juga kandunganvitamin A dan E. Ubi jalar ungu memiliki kandungan serat, karbohidat komplek, vitaminB6, asam folat, dan rendah kalori. Oleh karena kandungan antioksidannya, ubi jalar unguberpotensi dijadikan sebagai alternatif zat aktif antioksidan pada sediaan kosemtik.Penelitian ini bertujuan untuk mempelajari sifat fisik sediaan body scrub dari ekstrak cairubi jalar ungu dengan parameter daya lekat, daya sebar, pH dan Homogenitas. Jenispenelitian ini adalah eksperimental. Ubi jalar ungu diambil ekstraknya dengan cara diperasselanjutnya ekstrak dibuat dalam sedian krim body scrub. Krim dibuat dengan 3 (tiga)formulasi F1, F2, dan F3 dengan variasi konsentrasi ubi jalar ungu 35%, 40% dan 45%.Sediaan yang diperoleh diuji sifat fisiknya (Homogenitas, pH, daya sebar dan daya lekat).
Semua formula menunjukkan homogenitas yang baik. Uji pH pada F1, F2 dan F3 berturut-turut 6,4; 6,4 dan 6,5. Uji daya sebar pada ketiga formula didapatkan rata-rata daya sebar
F1, F2 dan F3 yaitu 3,5 cm, 4,8 cm dan 6,3 cm. Uji daya lekat pada ketiga formuladidapatkan rata-rata F1, F2 dan F3 yaitu 6,27 detik, 3,83 detik dan 3,52 detik. Berdasarkanhasil dapat disimpulkan semua formula mempunyai homogenitas dan pH yang memenuhisyarat. Daya sebar yang memenuhi syarat adalah F3 dan uji daya lekat memenuhi syaratuji syarat adalah F1.
PERBANDINGAN KADAR VITAMIN C PADA DAUN KELOR (Moringa oleifera) YANG TUMBUH DI DATARAN RENDAH, DATARAN RENDAH MENENGAH, DAN DATARAN TINGGI
Authors: Purwanti Ratih 
Published: August 2023

Tanaman kelor (Moringa oleifera L) dikenal juga sebagai tanaman obat berkhasiat dengan memanfaatkan seluruh bagian dari tanaman mulai dari daun, kulit batang, biji, hingga akarnya. Gizi yang terkandung dalam daun kelor (Moringa oleifera L) diantaranya protein, ß-karoten, nutrient C, mineral terutama zat besi dan kalsium. Nutrient C mempunyai peran penting dalam menjaga kebugaran tubuh dan membantu mencegah berbagai jenis penyakit. Penelitian ini bertujuan untuk Mengetahui perbandingan kadar vitamin C pada daun kelor (Moringa oleifera L) yang tumbuh di dataran rendah, dataran rendah menengah, dan dataran tinggi. Metode yang digunaka Penelitian ini merupakan penelitian eksperimental dengan menggunakan desain one-shot case study. Obyek penelitian adalah daun kelor muda (Moringa oleifera L) yang diambil dari dataran rendah (2,5 mdpl), dataran rendah menengah (325 mdpl), dataran tinggi (823 mdpl) yang diambil secara cluster sampling untuk menentukan daerah yang akan diambil dan proportionate stratified random sampling untuk menentukan daun yang digunakan. Hasil penelitian penetapan kadar vitamin C pada daun kelor (Moringa oleifera L) adalah 0,325% untuk dataran tinggi, 0,1951 % untuk dataran rendah menengah, dan 0,0975 % untuk dataran rendah. Kadar vitamin C tertinggi adalah tanaman kelor yang berasal dari dataran tinggi. Pada penelitain selanjutnya dapat dilakukan dengan metode penetapan kadar vitamin C yang lain.
Kata kunci : Tanaman kelor, Kadar vitamin C, Ketinggian tempat
HUBUNGAN ANTARA PENGETAHUAN ODAPUS DAN KEPATUHAN MINUM OBAT PADA ODAPUS MENGGUNAKAN METODE MMAS DAN LKQ DI MAGELANG
Authors: Siswatibudi Harpeni , Sunariyati Yuliana 
Published: August 2023

Latar Belakang: Lupus Eritematosus Sistemik (LES) merupakan penyakit autoimun kronik dengan manifestasi beragam yang kompleks yang membutuhkan penatalaksanaan secara individual. Banyak faktor yang mempengaruhi keberhasilan penatalaksanaan Lupus, dimana kepatuhan minum obat adalah salah satunya. Terkait hal tersebut, ternyata ada banyak hal yang mempengaruhi tingkat kepatuhan. Penelitian ini merupakan langkah awal intervensi penatalaksanaan komprehensif bagi Odapus, khususnya dalam lingkup lokal di Magelang.Tujuan: Tujuan umum penelitian ini adalah untuk mengetahui hubungan antara pengetahuan Odapus dan kepatuhan minum obat pada Odapus menggunakan metode MMAS dan LKQ di Magelang. Sementara tujuan khusus penelitian antara lain untuk mengetahui distribusi frekuensi, tingkat kepatuhan minum obat, dan tingkat pengetahuan Odapus di Magelang.Metode: Jenis penelitian yang dilakukan adalah penelitian analitik korelasi dengan pendekatan cross sectional.Populasi penelitian adalah seluruh Odapus di Magelang sebanyak 40 orang. Sampel sebanyak 40 orang dengan teknik total sampling. Pengambilan data menggunakan lembar kuesioner. Teknik analisis data menggunakan uji statistik Kendall Tau.Hasil: Distribusi frekuensi kepatuhan minum obat pada Odapus sebagian besar dengan kategori rendah sebanyak 28 responden (70.00%), sementara distribusi frekuensi pengetahuan pada Odapus sebagian besar dengan kategori baik sebanyak 24 responden (60.00%). Simpulan: Tidak ada hubungan signifikan antara tingkat pengetahuan dengan kepatuhan minum obat pada Odapus (p-value 0,134 > α 0,05). Mayoritas Odapus di Magelang berjenis kelamin wanita (97.50%), berusia 18-31 tahun (65.00%), mengenyam pendidikan SMA atau sederajat (52.50%) dan bekerja sebagai ibu rumah tangga (32.50%). Kebanyakan Odapus telah menyintas LES selama 3-5 tahun (40.00%), kontrol kembali ke poliklinik setiap bulan (90.00%), dan mengkonsumsi kombinasi lebih dari 3 jenis obat per hari. Jenis obat yang paling banyak dikonsumsi adalah kombinasi kortikosteroid dan DMARDs atau imunosupresan (50.00%).

Kata kunci: Lupus, Odapus, pengetahuan, kepatuhan minum obat
A Mixed-Membership Model for Social Network Clustering
Authors: Ouyang Guang , Dey Dipak K. , Zhang Panpan 
Published: August 2023

We propose a simple mixed membership model for social network clustering in this paper. A flexible function is adopted to measure affinities among a set of entities in a social network. The model not only allows each entity in the network to possess more than one membership, but also provides accurate statistical inference about network structure. We estimate the membership parameters using an MCMC algorithm. We evaluate the performance of the proposed algorithm by applying our model to two empirical social network data, the Zachary club data and the bottlenose dolphin network data. We also conduct some numerical studies based on synthetic networks for further assessing the effectiveness of our algorithm. In the end, some concluding remarks and future work are addressed briefly.
Clinicians’ interpretation of ventilation/perfusion (V/Q) lung scan reports: Where are we today?
Authors: Ismail A , Wong M L , Dhoodhat S , Vangu M D T 
Published: August 2023

Background. Clinicians’ interpretation of lung scan reports will determine which further management decisions are taken when potentially fatal pulmonary embolism (PE) is suspected.
Objectives. To assess current referring clinicians’ interpretation of the terminology used in ventilation/perfusion (V/Q) scan reports, whether this interpretation is affected by experience level, and how it affects clinical management decisions.
Methods. This was a questionnaire-based cross-sectional study. Between September 2020 and May 2021, 300 questionnaires were distributed among clinicians who refer patients for V/Q scans.
Results. Of the 162 clinicians who responded, 94% thought that there is >85% likelihood of PE or definitely PE present when a scan is reported as ‘high probability of PE’; 87% interpreted ‘low probability of PE’ as <10% likelihood of PE or definitely no PE present. Overall,>70% of clinicians across all experience levels correctly interpreted the intended meaning of probability categories according to the Modified Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED) II criteria. Of the respondents, 77% agreed that clinically significant PE is ruled out by a normal scan. Further investigation for inconclusive findings, features of parenchymal lung disease and cardiomegaly were selected by 72%, 93% and 98% of clinicians, respectively.
Conclusion. The findings of this study regarding high-probability scan results were in line with existing literature on lung scan report interpretation. However, our findings regarding low-probability scan results and negative V/Q scan specificity contrasted with the findings in these articles, suggesting that clinicians are now more familiar with lung scan interpretation guidelines. Experience level did not significantly affect interpretation of reports. Although most clinicians agreed that a negative scan excludes clinically significant PE, two-thirds of them would still subject the patient to further unnecessary investigations to exclude PE.
Complementary value of the Shock Index v. the Modified Shock Index in the prediction of in-hospital intensive care unit admission and mortality: A single-centre experience
Authors: Surendhar S , Jagadeesan S , Jagtap A B 
Published: August 2023

Background. Shock is a state of circulatory insufficiency that creates an imbalance between tissue oxygen supply and demand, resulting in end-organ dysfunction and hypodynamic circulatory failure. Most patients with infectious and trauma-related illnesses present to the emergency department (ED) in shock.
Objectives. To study the usefulness of the shock index (SI) and modified shock index (MSI) in identifying and triaging patients in shock presenting to the ED.
Methods. This was a year-long observational, cross-sectional study of 290 patients presenting to the ED of a tertiary hospital in compensated or overt shock. The SI and MSI were calculated at the time of first contact, and then hourly for the initial 3 hours. Relevant background investigations targeting the cause of shock and prognostic markers were done. The outcome measures of mortality and intensive care unit admission were documented for each participant.
Results. The mean age of the participants was 49 years, and 67% of them were men. In consensus with local and national data, the major medical comorbidities were hypertension (20%) and diabetes mellitus (16%). An SI ≥0.9 and an MSI ≥1.3 predicted in-hospital mortality (p<0.05) and ICU admission (p<0.05) with no significant superiority of the MSI over the SI in terms of mortality, although the MSI was a better surrogate marker for critical care admission.
Conclusion. The study showed the complementary value of the SI and MSI in triage in a busy tertiary hospital ED, surpassing their components such as blood pressure, heart rate and pulse pressure. We determined useful cut-offs for these tools for early risk assessment in the ED, and larger multicentre studies are needed to support our findings.
The hypoxia-associated genes in immune infiltration and treatment options of lung adenocarcinoma
Authors: Liu Liu , Han Lina , Dong Lei , He Zihao , Gao Kai , Chen Xu , Guo Jin-Cheng , Zhao Yi 
Published: August 2023

Background
Lung adenocarcinoma (LUAD) is a common lung cancer with a poor prognosis under standard chemotherapy. Hypoxia is a crucial factor in the development of solid tumors, and hypoxia-related genes (HRGs) are closely associated with the proliferation of LUAD cells.

Methods
In this study, LUAD HRGs were screened, and bioinformatics analysis and experimental validation were conducted. The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases were used to gather LUAD RNA-seq data and accompanying clinical information. LUAD subtypes were identified by unsupervised cluster analysis, and immune infiltration analysis of subtypes was conducted by GSVA and ssGSEA. Cox regression and LASSO regression analyses were used to obtain prognosis-related HRGs. Prognostic analysis was used to evaluate HRGs. Differences in enrichment pathways and immunotherapy were observed between risk groups based on GSEA and the TIDE method. Finally, RT-PCR and in vitro experiments were used to confirm prognosis-related HRG expression in LUAD cells.

Results
Two hypoxia-associated subtypes of LUAD were distinguished, demonstrating significant differences in prognostic analysis and immunological characteristics between subtypes. A prognostic model based on six HRGs (HK1, PDK3, PFKL, SLC2A1, STC1, and XPNPEP1) was developed for LUAD. HK1, SLC2A1, STC1, and XPNPEP1 were found to be risk factors for LUAD. PDK3 and PFKL were protective factors in LUAD patients.

Conclusion
This study demonstrates the effect of hypoxia-associated genes on immune infiltration in LUAD and provides options for immunotherapy and therapeutic strategies in LUAD.
Prevalence of risk factors associated with rupture of abdominal aortic aneurysm (AAA): a single center retrospective study
Authors: Liu Sudong , Long Caifu , Hong Yuanjia , Gu Xiaodong , Weng Ruiqiang , Zhong Zhixiong 
Published: August 2023

Background
Abdominal aortic aneurysm (AAA) is a severe cardiovascular disease. The mortality rate for an AAA rupture is very high. Understanding the risk factors for AAA rupture would help AAA management, but little is known about these risk factors in the Chinese population.

Methods
This retrospective study included patients that were diagnosed with AAA during the last 5 years in a large national hospital in southern China. AAA patients were divided into a rupture and non-rupture group. Clinical data were extracted from the hospital medical record system. Clinical features were compared between the rupture and non-rupture groups. The associations between potential risk factors and rupture risk were evaluated using a multivariate logistic regression analysis.

Results
A total of 337 AAA patients were included for analysis in the present study. AAA diameter was significantly larger, and high-sensitivity C-reactive protein (hs-CRP) and serum creatinine levels were both significantly higher in AAA rupture patients. High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels were significantly lower in AAA rupture patients. After adjustment, the multivariate logistic analysis found that AAA diameter and hs-CRP were independently positively associated with AAA rupture, and HDL-C level was adversely associated with AAA rupture.

Conclusions
Our data suggests that larger AAA diameter and higher hs-CRP level are associated with a higher risk of AAA rupture, and higher HDL-C level is associated with a lower risk of AAA rupture. The results of this study may be helpful for the management of AAA patients in southern China.
Elucidating the Anti-Inflammatory Properties of Garcinia kola and Vernonia amygdalina through in silico Molecular Biology Techniques
Authors: Morebise Olugbenga , Chukuka Chimere , Adeleke Otitosan , Alexander Kimberley Jilliene , Ezenwa Carolyn , Ajadi Khaleed Desmond , Ikpama Wisdom , Iyke-Anunagba Erica Makuochukwu , Jackson Kurlyene Adrienne 
Published: August 2023

Introduction: Inflammation is implicated in many disorders, including communicable and noncommunicable diseases. Cyclooxygenase-2 (Cox-2) is a key enzyme involved in the production of prostaglandins implicated in inflammatory disorders. Garcinia kola and Vernonia amygdalina are medicinal plants being used for treating various ailments in many parts of the world and extensive in vitro and in vivo studies have been conducted on them. Five phytochemicals were selected from the two plants; aspirin and celecoxib were used as reference drugs. This study investigated the interactions of the seven ligands with the Cox-2 enzyme, using in silico molecular biology techniques.
Materials and Methods: The 3-D structures of the seven ligands were retrieved from the PubChem database in their Structure Data Format (SDF). Cox-2 was retrieved in its Protein Data Bank (PDB) format. The ligands and the protein were converted to their pdbqt formats through the open babel software. The Cox-2 was docked with the ligands using the Auto-Dock Vina software. The binding energies and the root mean square deviation values were noted. Pharmacophore modeling was visualized by using the Biovia Discovery Studio Visualizer. One of the ligands (luteolin) was further subjected to molecular dynamics simulation using the desmond maestro software.
Results: While celecoxib had the best binding property with Cox-2 (-10.8 kcal/mol, 3 H bonds), the five ligands from the two plants had better binding properties than aspirin (which had -6.5kcal/mol, 1 H bond). Kolaviron, from G. kola (-9.1 kcal/mol, 3 H bonds) and luteolin, from V. amygdalina (-8.5kcal/mol, 2 H bonds) demonstrated the best binding properties among the five phytochemicals. Additional interactions of H bonds and hydrophobic bonds were noticed post molecular dynamics simulation of luteolin with Cox-2, indicating dynamic forces’ fluctuations. MD simulations showed that Ser530 and Tyr385 were the best amino acid side chains that interacted with luteolin for the stabilization of the protein-ligand complex.
Conclusion: The energy values and protein-ligand interactions indicate affinity and stability of the complex. Luteolin can be taken as a promising drug target and subjected to ADMET (absorption, distribution, metabolism, excretion, toxicity) properties analysis and clinical trials. This is especially important in view of the various side effects associated with both nonselective and selective Cox-2 inhibitors, including aspirin and celecoxib.
Aphrodisiac Potentials of Methanol Extract of Homalium letestui Root in Male Rats
Authors: Udofia Ofonimeh Emmanuel , Nwafor Paul Alozie , Uffia Ifiok Dominic , Elijah Nya  
Published: August 2023

Aims: In this study, the methanol extract of Homalium letestui root was investigated with a view to ascertaining the scientific basis for its ethnobotanical use, and establishing, if any, the mechanisms of its effects, as an aphrodisiac.
Methodology: The crushed root of Homalium letestui was soaked in methanol for 72h and filtered with Whatman paper No.4; the extract was stored at -4oC. Mature male rats were divided into three groups (active, sluggish, and impotent) and administered with various doses of the extract. The rats were, thereafter, observed for the following: mount latency, intromission latency, ejaculation latency, post ejaculation latency, mount frequency, intromission frequency, erection frequency, and penile erection latency.
Results: The result showed that the Homalium letestui root extract (n-butanol, dichloromethane, ethyl acetate, petroleum ether and aqueous fractions) caused and maintained erection in the subjects, and their effects on the rats were dose-dependent and statistically significant (p<0.05-0.001). In addition, the aphrodisiac properties of the Homalium letestui root may in part be predicated on the properties of its phytochemical constituents which include alkaloids, saponins, flavonoids, tannins and cardiac glycosides.
Conclusion: These findings, therefore, justify the Homalium letestui root’s folkloric use as a sexual performance enhancer and demonstrate that the plant possesses aphrodisiac properties.
WSN Based Irrigation Management in Beans
Authors: Vimala M. , Ranjan Rajeev , Hanumanthappa D. C. 
Published: August 2023

Wireless sensor network is an important technology in agriculture to enhance the efficiency, productivity and profitability of farming with minimal use of inputs. Maintaining uniformity of soil moisture throughout the crop growth is of greater importance to achieve maximum yield. Hence, a field experiment entitled “WSN based irrigation management in beans” was conducted at ZARS, GKVK, Bengaluru during kharif 2021. This study was aimed to know the effect of sensor based irrigation management on the performance of beans, water saving and water use efficiency (WUE). For the sensor based irrigation treatment, irrigation was provided when available moisture in the soil was depleted for about 25-30 per cent. Results indicated that, sensor based irrigation recorded significantly higher beans yield (6972 kg ha-1) which enhanced crop yield by 18.87 per cent and saved water to the tune of 26.66 per cent over conventional method of irrigation. This could help farming community to boost income.