bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of US Public R&D Investments on Agricultural Productivity and GHG Emissions
Authors: Baldos Uris Lantz C. 
Published: September 2023

AbstractThis study formally links the literature on R&D-driven productivity growth to studies which examine GHG emission benefits from increased farm productivity growth. Using a global agricultural model and estimates from the literature, this study examines the impact of greater US public agricultural R&D spending over 2025−2035. The results show that roughly doubling public R&D investments in US agriculture could provide greater economic gains relative to its costs over the period 2017−2050. The GHG mitigation co-benefits from these investments also can be enhanced by combining R&D policies with strategies aimed at directly reducing farm inputs.
Towards the characterisation of sustainable diet’s gut microbiota composition and functions: A narrative review
Authors: Lares-Michel Mariana , Reyes-Castillo Zyanya , Housni Fatima Ezzahra 
Published: September 2023

AbstractThe gut microbiome is a key element for health preservation and disease prevention. Nevertheless, defining a healthy gut microbiome is complex since it is modulated by several factors, such as host genetics, sex, age, geographical zone, drug use, and, especially, diet. Although a healthy diet has proven to increase microbial alpha and beta diversity and to promote the proliferation of health-related bacteria, considering the current environmental and nutritional crisis, such as climate change, water shortage, loss of diversity, and the obesity pandemic, it should be highlighted that a healthy diet is not always sustainable. Sustainable diets are dietary patterns that promote all dimensions of people’s health and well-being while exerting low pressure on the environment, and being accessible, affordable, safe, equitable, and culturally acceptable. Examples of diets that tend to be sustainable are the Planetary Health Diet of the EAT-Lancet Commission or territorial diets such as the Mediterranean and the Traditional Mexican diet (milpa diet), adapted to specific contexts. These diets are principally plant-based but include small or moderate amounts of animal-based foods. Characterising the effects of sustainable diets on gut microbiota is urgent to ensure that the benefits for human health are aligned with environmental preservation and respect the sociocultural aspects of individuals.
Pretending to Support? Duterte's Popularity and Democratic Backsliding in the Philippines
Authors: Kasuya Yuko , Miwa Hirofumi 
Published: September 2023

Abstract
The incumbent-led subversion of democracy represents the most prevalent form of democratic backsliding in recent decades. A central puzzle in this mode of backsliding is why these incumbents enjoy popular support despite their actions against democracy. We address this puzzle using the case of Philippine President Rodrigo Duterte. Although some Philippine analysts have speculated that his popularity was inflated due to social desirability bias (SDB) among survey respondents, there has been limited empirical examination. Our pre-registered list experiment surveys conducted in February/March 2021 detected SBD-induced overreporting at about 39 percentage points in face-to-face surveys and 28 percentage points in online surveys. We also found that the poor Mindanaoans, and those who believed their neighbors supported Duterte, were more likely to respond according to SDB. These possibly counter-intuitive results should be interpreted with caution because the survey was conducted during the height of the COVID-19 lockdown, and the findings cannot necessarily be extrapolated to the other period of his presidency. Nevertheless, this study suggests that preference falsification could be an alternative explanation for the puzzle of popular incumbents in democratic backsliding.
Dietary saturated fat and cholesterol: cracking the myths around eggs and cardiovascular disease
Authors: Antoni Rona 
Published: September 2023

Abstract
Whilst dietary cholesterol guidelines have waivered through the years with historic restrictions lifted for the majority of the general population, recommendations to reduce saturated fat intake have been the mainstay of dietary guidelines since the 1980s and were recently reinforced by the Scientific Advisory Committee on Nutrition (SACN). Cholesterol metabolism is complex, with saturated fat known to have a more significant contribution at raising levels of low-density lipoprotein (LDL) cholesterol, a well-established risk factor for cardiovascular disease (CVD). However, it is clear from metabolic research that hyper-responsiveness to both dietary cholesterol and saturated fat exists; hence, for specific subsets of the population, reductions in both nutrients may be indicated. With this in mind, the current article aims to provide an overview of the mechanisms underlying biological variation in responsiveness and introduces research currently underway which will hopefully identify simple biomarkers that can be used to predict responsiveness and permit tailored, personalised, dietary advice. Eggs are a well-known source of dietary cholesterol whilst being low in saturated fat. A common question encountered in clinical practice is must individuals limit intake to manage blood cholesterol levels. This article summarises key recent papers which confirm that eggs can be enjoyed as part of a healthy balanced diet, whilst highlighting the need for further research in certain population groups, e.g. in individuals with diabetes.
The burden of major depressive disorder in the Middle East and North Africa region, 1990–2019
Authors: Safiri Saeid , Mousavi Seyed Ehsan , Nejadghaderi Seyed Aria , Noori Maryam , Sullman Mark J. M. , Kolahi Ali-Asghar , Shekarriz-Foumani Reza 
Published: September 2023

AbstractBackground:Major depressive disorder (MDD) is one of the leading causes of disability. We aimed to report the MDD-attributable prevalence, incidence and years lived with disability (YLDs) in the Middle East and North Africa (MENA) region from 1990 to 2019 by age, sex and socio-demographic index (SDI).Methods:Publicly available data on the burden of MDD were retrieved from the Global Burden of Disease (GBD) study 2019 for the 21 countries in MENA. The counts and age-standardised rates (per 100,000) were presented, along with their corresponding 95% uncertainty intervals.Results:In 2019, MDD had an age-standardised point prevalence of 3322.1 and an incidence rate of 4921.7 per 100,000 population in MENA. Furthermore, there were 4.1 million YLDs in 2019. However, there were no substantial changes in the MDD burden over the period 1990–2019. In 2019, Palestine had the highest burden of MDD. The highest prevalence, incidence and YLDs attributable to MDD were found in the 35–39 age group. In 2019, the YLD rate in MENA was higher than the global rate for almost all age groups. Furthermore, there was a broadly negative association between the YLD rate and SDI.Conclusion:The study highlights the need to prevent the disorder using a multidisciplinary approach and for the provision of cost-effective treatments for those affected, in order to increase their quality of life.
Holocene millennial-scale variability of coastal environments on the southern coast of Korea and its controlling factors
Authors: Lim Jaesoo , Yi Sangheon , Kim Youngeun 
Published: September 2023

AbstractCoastal evolution is influenced by past sea-level changes and resultant shifts from fluvial- to marine-dominant environments and the accompanying significant geochemical and isotopic changes in the water mass and sediments. We investigated the elemental and isotopic features of coastal sedimentary cores (27 m in length) from a small paleo-bay located on the southern coast of Korea to determine such geochemical variability and specify past changes in the bay environment and anoxic conditions and possible links to past climate changes. We analyzed total organic carbon (TOC), total sulfur (TS), their isotopes (δ13CTOC and δ34STS), and pyrite. The δ13CTOC values ranging from −25 to −19‰ (a proxy for terrestrial influence) were lower than average (−22.5‰) before 8300 cal yr BP and since 500 cal yr BP, while the intervening Early to Late Holocene showed higher δ13CTOC values, indicating a shallow coastal environment. The δ34STS values fluctuating between −35 and +5‰ resembled sedimentation rate change. Based on the changes in the ratios of TOC to TS (C/S ratios), sedimentation rate, and δ34STS, we found five possible periods with higher salinity and intensified anoxic conditions at millennial timescales: 8900–8200, 7950–6500, 5200–4300, 3500–2600, and 2000–1100 cal yr BP. These intensified anoxic conditions seem to have been influenced by increased air temperature and sea-surface temperature conditions, which could have intensified the intensity of thermal stratification (less ventilation and mixing) between surface and bottom waters and resultant anoxic conditions.
Dairy products and brain structure in French older adults
Authors: Pellay Hermine , Thomas Aline , Baillet Marion , Helmer Catherine , Catheline Gwénaëlle , Marmonier Corinne , Samieri Cécilia , Féart Catherine 
Published: September 2023

AbstractAmong food groups with putative benefits for brain structures, dairy products (DP) have been poorly studied. The sample included participants without dementia from the ancillary brain imaging study of the Three-City cohort who were aged 65+ years, had their DP intake assessed with a FFQ at baseline and underwent an anatomical scan 3 years (n 343) or 9 years (n 195) after completing the dietary survey. The frequencies of consumption of total DP, milk and cheese were not associated with brain structure. Compared with the lowest frequency, the highest frequency of fresh DP (F-DP) consumption (< 0·5 v. > 1·5 times/d) was significantly associated with a lower medial temporal lobe volume (MTLV) (β = −1·09 cm3, 95 % CI − 1·83, −0·36) 9 years later. In this population-based study of older adults, the consumption of F-DP more than 1·5 times/d was associated with a lower MTLV, which is considered an early biomarker of Alzheimer’s disease, 9 years later. This original study should be replicated in different settings before conclusions are drawn.
Association of dietary and lifestyle inflammation score with type 2 diabetes mellitus and cardiometabolic risk factors in Iranian adults: Sabzevar Persian Cohort Study
Authors: Bakhshimoghaddam Farnush , Jafarirad Sima , Maraghi Elham , Ghorat Fereshteh 
Published: September 2023

AbstractSystemic inflammation may contribute to the initiation and progression of type 2 diabetes mellitus (T2DM) through diet and lifestyle. We examined the association of dietary inflammation score (DIS), lifestyle inflammation score (LIS) and dietary and lifestyle inflammation score (DLIS) with T2DM and cardiometabolic risk factors among Iranian adults. In this study, we identified and recruited 619 patients with T2DM and 2113 without T2DM from 35 to 75 years old men and women in the baseline phase of the Sabzevar Persian Cohort Study. Using a validated 115-item semi-quantitative FFQ, we calculated a 19-component DIS and a 3-component LIS weighted by circulating inflammation biomarkers. The DIS, LIS and DLIS associations with diabetes were assessed by multivariable logistic regression analysis. The average age of the participants was 48·29 (sd 8·53) (without T2DM: 47·66 (sd 8·42); with T2DM: 50·44 (sd 8·57)). Individuals in the highest compared with the lowest tertiles of DLIS (OR: 3·40; 95 % CI 2·65, 4·35; Ptrend < 0·001), DIS (OR: 3·41; 95 % CI 2·66, 4·38; Ptrend < 0·001) and LIS (OR: 1·15; 95 % CI 0·90, 1·46; Ptrend = 0·521) had an increased risk of T2DM. For those in the highest relative to the lowest joint DIS and LIS tertiles, the results were OR: 3·37; 95 % CI 2·13, 5·32; Pinteraction < 0·001. No significant associations were found between DLIS and cardiometabolic risk factors, including blood pressure, liver enzymes and glycaemic and lipid profiles, except for waist circumference (P < 0·001) and waist-to-hip ratio (P = 0·010). A higher DIS and DLIS score was associated with a higher risk of T2DM, while the LIS score was not associated with T2DM risk.
Vitamin A biomarkers were associated withα(1)-acid glycoprotein and C-reactive protein over the course of a human norovirus challenge infection
Authors: Victor Courtney P. , Leon Juan S. , Williams Anne M. 
Published: September 2023

AbstractRetinol binding protein (RBP) is used as a proxy for retinol in population-based assessments of vitamin A deficiency (VAD) for cost-effectiveness and feasibility. When the cut-off of < 0·7 μmol/l for retinol is applied to RBP to define VAD, an equivalence of the two biomarkers is assumed. Evidence suggests that the relationship between retinol and RBP is not 1:1, particularly in populations with a high burden of infection or inflammation. The goal of this analysis was to longitudinally evaluate the retinol:RBP ratio over 1 month of follow-up among fifty-two individuals exposed to norovirus (n26 infected,n26 uninfected), test whether inflammation (measured asα-1-acid glycoprotein (AGP) and C-reactive protein (CRP)) affects retinol, RBP and the ratio between the two and assess whether adjusting vitamin A biomarkers for AGP or CRP improves the equivalence of retinol and RBP. We found that the median molar ratio between retinol and RBP was the same among infected (0·68) and uninfected (0·68) individuals. AGP was associated with the ratio and RBP individually, controlling for CRP, and CRP was associated with both retinol and RBP individually, controlling for AGP over 1 month of follow-up. Adjusting for inflammation led to a slight increase in the ratio among infected individuals (0·71) but remained significantly different from the expected value of one. These findings highlight the need for updated recommendations from the WHO on a cut-off value for RBP and an appropriate method for measuring and adjusting for inflammation when using RBP in population assessments of VAD.
Theory matters for identifying a causal role for genetic factors in socioeconomic outcomes
Authors: Durlauf Steven N. , Rustichini Aldo 
Published: September 2023

Abstract
Any empirical claim about the role of genes in socioeconomic outcomes involves successfully addressing the identification problem. This commentary argues that socioeconomic outcomes such as education are sufficiently complex, involving so many mechanisms, that understanding the role genes requires the use of formal theoretical structures.
Polygenic scores, and the genome-wide association studies they derive from, will have difficulty identifying genes that predispose one to develop a social behavioral trait
Authors: Fox Edward 
Published: September 2023

Abstract
Polygenic scores (PGSs) have several limitations. They are confounded with environmental effects on behavior and cannot be used to study how mutations affect brain function and behavior. For this, mutations with large effects, which often arise in only one geographical population are needed. Genome-wide association studies (GWASs), commonly used for identifying mutations, have difficulty detecting these mutations. A strategy that overcomes this challenge is discussed.
True to form: Media and data technologies of self-inscription
Authors: Oertzen Christine von 
Published: September 2023

ArgumentThis paper examines self-inscription, a mode of census enumeration that emerged during the nineteenth century. Starting in the 1840s, a number of European states introduced self-inscription as an auxiliary means to facilitate the work of enumerators. However, a decisive shift occurred when Prussian census statisticians implemented self-inscription via individual “Zählkarten”—or “counting cards”—in 1871. The paper argues that scientific ideals of accuracy and precision prevalent in the sciences at the time motivated Prussian census officials to initiate self-inscription as an at-home scenario unmediated by enumerators, in which the census form alone was to yield truthful information from the respondents. By illuminating the bureaucratic means for implementing scientific ideals and practices in gathering personal census data, the paper offers an in-depth analysis of the media, technologies, and manpower that census takers deployed to reveal the epistemic—as well as social and political—impact of being “true to form.”
Language proficiency modulates L2 orthographic learning mechanism: Evidence from event-related brain potentials in overt naming
Authors: Fu Yang , Bermúdez-Margaretto Beatriz , Beltrán David , Huili Wang , Dominguez Alberto 
Published: September 2023

AbstractThe present study investigates bilinguals’ capacity to rapidly establish memory traces for novel word forms in a second language (L2), as a function of L2 linguistic proficiency. A group of Chinese-English bilinguals with various English proficiency levels were presented with a reading-aloud task, consisting of 16 pseudowords and 16 English words repeatedly presented across six training exposures. Behavioral and neurophysiological data were collected, and modulations in the word-length effect across repetitions were measured as an index of transition from sublexical to lexical involvement. Results revealed that higher L2 proficiency was associated with decreased word-length effect on novel words, reflected in both naming latencies and early N1 and P200 brain responses. In contrast, lower proficiency learners appeared to engage in effortful letter-to-sound decoding processes, with higher attentional allocation to the letter sequence and greater use of sublexical processing across exposures. Our findings highlight the need to tackle specific grapheme-to-phoneme skills for efficient learning of L2, particularly in populations where the L1 is nonalphabetic.
Duration of untreated illness in gambling disorder
Authors: Grant Jon E. , Chamberlain Samuel R. 
Published: September 2023

AbstractObjectiveGambling disorder is common, affects 0.5–2% of the population, and is under-treated. Duration of untreated illness (DUI) has emerged as a clinically important concept in the context of other mental disorders, but DUI in gambling disorder, has received little research scrutiny.MethodsData were aggregated from previous clinical trials in gambling disorder with people who had never previously received any treatment. DUI was quantified, and clinical characteristics were compared as a function of DUI status.ResultsA total of 298 individuals were included, and the mean DUI (standard deviation) was 8.9 (8.4) years, and the median DUI was 6 years. Longer DUI was significantly associated with male gender, older age, earlier age when the person first started to gamble, and family history of alcohol use disorder. Longer DUI was not significantly associated with racial-ethnic status, gambling symptom severity, current depressive or anxiety severity, comorbidities, or disability/functioning. The two groups did not differ in their propensity to drop out of the clinical trials, nor in overall symptom improvement associated with participation in those trials.ConclusionsThese data suggest that gambling disorder has a relatively long DUI and highlight the need to raise awareness and foster early intervention for affected and at-risk individuals. Because earlier age at first gambling in any form was strongly linked to longer DUI, this highlights the need for more rigorous legislation and education to reduce exposure of younger people to gambling.
Association of maternal psychosocial stress with newborn body composition in the Healthy Start study
Authors: Buck Kaitlin E. , Dhaliwal Satvinder K. , Dabelea Dana , Perng Wei 
Published: September 2023

AbstractMaternal psychosocial stress is associated with delivery of both small- and large-for-gestational-age newborns. Prior studies have relied on methods that do not capture fat mass (FM) vs. fat-free mass (FFM). We aimed to assess the relationship of maternal psychosocial stress, using the Edinburgh Postnatal Depression Scale (EPDS) and Cohen’s Perceived Stress Scale (PSS), with newborn body composition. The sample included 604 mother/newborn pairs in the Healthy Start study. We used linear regression to examine associations of EPDS (>6.5 vs. ≤6.5) and PSS (>21 vs. ≤21) with newborn adiposity (FM and %FM measured by air displacement plethysmography [ADP], BMI-for-age, weight-for-length, and weight-for-age z-scores) and lean mass (FFM and length-for-age z-score). Average age of the women was 29.2 ± 6 y. Fifty-five percent of the women were white, 26.2% Hispanic, and 12.1% Black. Twenty-four percent of women had EPDS >6.5 and 18.1% had PSS >21. Mean ± SD birthweight was 3136 ± 437 g. After adjustment for confounders, EPDS >6.5 vs. ≤6.5 corresponded with 35.3 (95% CI: 6.6, 64.0) g lower offspring FM and 0.18 (−0.03, 0.39) units shorter length z-score. PSS was not associated with any neonatal outcomes. Maternal psychosocial stress is associated with delivery of shorter newborns with less FM.
Low‐Latitude Forcing and High‐Latitude Response of the South Asian Summer Monsoon Through the Pliocene
Authors: Zhang Ze , Huang Chunju , Kemp David B. , Xu Yuqi , Cao Mengmeng , Wang Zhixiang 
Published: September 2023

AbstractPrecipitation carried by the Asian summer monsoon influences the livelihoods of millions of people, and there has been a great deal of work trying to reveal the driving mechanisms behind past changes. Compared to the widely studied East Asian summer monsoon, the behavior of the South Asian summer monsoon (SASM) in the Pliocene is still not well known. Here, we present new high‐resolution geochemical (Rb/Sr and Ti) data from the lacustrine Yuanmou Basin (Southwest China) spanning the Pliocene to early Pleistocene (4.30–2.0 Ma) that permit detailed analysis of hydroclimate changes related to orbital‐scale SASM variability. We find a clear weakening of the SASM at 2.9–2.75 Ma, which may be related to warming in the high‐latitude southern hemisphere and a weakening of atmospheric circulation at low latitudes over the Indian Ocean. Our results highlight that 405‐ and 100‐Kyr eccentricity forcing had a dominant role in driving climate change in the Yuanmou Basin during the Pliocene to early Pleistocene. Based on analysis of our data from the Yuanmou Basin, coupled with marine data from the Arabian Sea, we suggest that orbital‐scale SASM variability during the Pliocene was mainly controlled by changes in low‐latitude insolation. In addition, oscillations of the West Antarctic ice sheet after ∼3.5 Ma also significantly influenced the evolution of the SASM on orbital time scales.