bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who considers becoming a world language teacher? Comparing students who would with those who won't
Authors: Davis William S. , Liu Bo , Kim Josephine 
Published: August 2023

AbstractGiven the ongoing shortage of world language teachers in the United States, growing attention has developed toward recruiting new teachers at the secondary and postsecondary levels. This mixed methods study examined why some university noneducation students involved in language study at a large public institution indicated they would consider becoming a teacher (N = 116) while others would not (N = 129). Analyses indicated that those who would consider the profession were significantly more motivated for language study and had perceived experiencing significantly more instances of communicative and authentic pedagogy, as well as feelings of autonomy, community, and capability in their current language course than their counterparts who would not consider the profession. While passion for languages, teaching, and social contribution were factors that drew students to the profession, those who would not consider world language teaching were primarily dissuaded by a lack of passion for languages and teaching and perceptions of their own inadequate language proficiency.
Canola variety, nitrogen, phosphorus, and sulfur fertilization affect yield, quality, and fatty acid profile
Authors: Crittenden Stephen , Clayton George , Boyce Marley , Deng Xinmin , Grant Cynthia 
Published: August 2023

Canola yield and quality are important for food, feed, and industrial end-uses. There may be trade-offs between the agronomic and quality aspects of canola production depending on varietal traits and management. The objective of this work was to assess the effects of nitrogen (N), phosphorus (P), and sulfur (S) fertilization on agronomic and quality properties of canola varieties with distinct oleic acid contents. Nitrogen fertilization rates were 0, 25, 50, or 100 kg·ha−1, P rates were 0 or 30 kg·ha−1, and S rates were 0 or 20 kg·ha−1. Canola was grown in 2003, 2004, and 2005 at Brandon, a private farm close to Brandon, and at Lacombe, Canada. Canola yields averaged 2.36 t·ha−1 for conventional, 2.53 t·ha−1 for low, and 2.2 t·ha−1 for the high oleic acid varieties at maximum fertilization of N, P, and S. The high oleic acid variety averaged 75% oleic acid content, whereas the low variety averaged 65%, and the conventional variety 62%. Total saturated fatty acids were greatest with the conventional oleic acid variety, and tended to increase with N, decrease with S, and were not influenced by P. The high oleic acid variety yielded slightly less than the other two varieties but tended to have lower glucosinolate and saturated fatty acid contents. This work could have implications for human nutrition or other end-uses. Current canola varieties and fertility management should be studied to produce canola with quality tailored for the end use.
A Ternary Metal Oxide-Reduced Graphene Oxide Composite as High Capacity and Durable Anode for Li-Ion Batteries
Authors: T. K. M. Prashantha Kumar , Tripathy Debashis , Aiyer Hemantkumar , Sampath S. 
Published: August 2023

A ternary metal oxide, bismuth stannate and its carbon composite are prepared by a solution synthesis approach. The as-prepared materials are checked for phase purity by X-ray diffraction and characterized by various characterization techniques. The composite electrode performs better compared to pristine material when investigated as anodes for Li-ion batteries (LIBs). The use of an electrolyte additive leads to improved performance. High capacity of 960 mAh g−1 is obtained at 100 mA g−1 for LIBs. At a high-rate of 1000 mA g−1, 1250 stable cycles are observed with very good capacity retention, and the capacity is ∼475 mAh g−1 at the end of the cycling. As investigated by different techniques, both conversion and alloying reactions are responsible for such high performance. The carbon network improves the conductivity and stabilize the intermediates formed during cycling. Further, the full cell studies with the composite anode and LiFePO4 cathode show good performance.
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
Authors: Sun Xuejing , Lu Yao , Wu Junru , Wen Qing , Li Zhengxin , Tang Yan , Shi Yunmin , He Tian , Liu Lun , Huang Wei , Weng Chunyan , Wu Qing , Xiao Qingzhong , Yuan Hong , Xu Qingbo , Cai Jingjing 
Published: August 2023

BACKGROUND:
Tertiary lymphoid organs (TLOs) are ectopic lymphoid organs developed in nonlymphoid tissues with chronic inflammation, but little is known about their existence in different types of vascular diseases and the mechanism that mediated their development.

METHODS:
To take advantage of single-cell RNA sequencing techniques, we integrated 28 single-cell RNA sequencing data sets containing 5 vascular disease models (atherosclerosis, abdominal aortic aneurysm, intimal hyperplasia, isograft, and allograft) to explore TLOs existence and environment supporting its growth systematically. We also searched Medline, Embase, PubMed, and Web of Science from inception to January 2022 for published histological images of vascular remodeling for histological evidence to support TLO genesis.

RESULTS:
Accumulation and infiltration of innate and adaptive immune cells have been observed in various remodeling vessels. Interestingly, the proportion of such immune cells incrementally increases from atherosclerosis to intimal hyperplasia, abdominal aortic aneurysm, isograft, and allograft. Importantly, we uncovered that TLO structure cells, such as follicular helper T cells and germinal center B cells, present in all remodeled vessels. Among myeloid cells and lymphocytes, inflammatory macrophages, and T helper 17 cells are the major lymphoid tissue inducer cells which were found to be positively associated with the numbers of TLO structural cells in remodeled vessels. Vascular stromal cells also actively participate in vascular TLO genesis by communicating with myeloid cells and lymphocytes via CCLs (C-C motif chemokine ligands), CXCL (C-X-C motif ligand), lymphotoxin, BMP (bone morphogenetic protein) chemotactic, FGF-2 (fibroblast growth factor-2), and IGF (insulin growth factor) proliferation mechanisms, particularly for lymphoid tissue inducer cell aggregation. Additionally, the interaction between stromal cells and immune cells modulates extracellular matrix remodeling. Among TLO structure cells, follicular helper T, and germinal center B cells have strong interactions via TCR (T-cell receptor), CD40 (cluster of differentiation 40), and CXCL signaling, to promote the development and maturation of the germinal center in TLO. Consistently, by reviewing the histological images from the literature, TLO genesis was found in those vascular remodeling models.

CONCLUSIONS:
Our analysis showed the existence of TLOs across 5 models of vascular diseases. The mechanisms that support TLOs formation in different models are heterogeneous. This study could be a valuable resource for understanding and discovering new therapeutic targets for various forms of vascular disease.
Pannexin 1 Modulates Angiogenic Activities of Human Endothelial Colony-Forming Cells Through IGF-1 Mechanism and Is a Marker of Senescence
Authors: Tien Ting-Yi , Wu Yih-Jer , Su Cheng-Huang , Hsieh Chin-Ling , Wang Bo-Jeng , Lee Yi-Nan , Su Yeu , Yeh Hung-I 
Published: August 2023

BACKGROUND:
We examined the role of Panxs (pannexins) in human endothelial progenitor cell (EPC) senescence.

METHODS:
Young and replication-induced senescent endothelial colony-forming cells (ECFCs) derived from human circulating EPCs were used to examine cellular activities and senescence-associated indicators after transfection of short interference RNA specific to Panx1 or lentivirus-mediated Panx1 overexpression. Hind limb ischemia mice were used as in vivo angiogenesis model. Protein and phospho-kinase arrays were used to determine underlying mechanisms.

RESULTS:

Panx1 was the predominant Panx isoform in human ECFCs and upregulated in both replication-induced senescent ECFCs and circulating EPCs from aged mice and humans. Cellular activities of the young ECFCs were enhanced by Panx1 downregulation but attenuated by its upregulation. In addition, reduction of Panx1 in the senescent ECFCs could rejuvenate cellular activities with reduced senescence-associated indicators, including senescence-associated β-galactosidase activity, p16
INK4a
(cyclin-dependent kinase inhibitor 2A), p21 (cyclin-dependent kinase inhibitor 1), acetyl-p53 (tumor protein P53), and phospho-histone H2A.X (histone family member X). In mouse ischemic hind limbs injected senescent ECFCs, blood perfusion ratio, salvaged limb outcome, and capillary density were all improved by Panx1 knockdown. IGF-1 (insulin-like growth factor 1) was significantly increased in the supernatant from senescent ECFCs after Panx1 knockdown. The enhanced activities and paracrine effects of Panx1 knockdown senescent ECFCs were completely inhibited by anti–IGF-1 antibodies. FAK (focal adhesion kinase), ERK (extracellular signal-regulated kinase), and STAT3 (signal transducer and activator of transcription 3) were activated in senescent ECFCs with Panx1 knockdown, in which the intracellular calcium level was reduced, and the activation was inhibited by supplemented calcium. The increased IGF-1 in Panx1-knockdown ECFCs was abrogated, respectively, by inhibitors of FAK (PF562271), ERK (U0126), and STAT3 (NSC74859) and supplemented calcium.

CONCLUSIONS:
Panx1 expression is upregulated in human ECFCs/EPCs with replication-induced senescence and during aging. Angiogenic potential of senescent ECFCs is improved by Panx1 reduction through increased IGF-1 production via activation of the FAK-ERK axis following calcium influx reduction. Our findings provide new strategies to evaluate EPC activities and rejuvenate senescent EPCs for therapeutic angiogenesis.
Combined Estimation of Vehicle Dynamic State and Inertial Parameter for Electric Vehicles Based on Dual Central Difference Kalman Filter Method
Authors: Jin Xianjian , Yang Junpeng , Xu Liwei , Wei Chongfeng , Wang Zhaoran , Yin Guodong 
Published: August 2023

AbstractDistributed drive electric vehicles (DDEVs) possess great advantages in the viewpoint of fuel consumption, environment protection and traffic mobility. Whereas the effects of inertial parameter variation in DDEV control system become much more pronounced due to the drastic reduction of vehicle weights and body size, and inertial parameter has seldom been tackled and systematically estimated. This paper presents a dual central difference Kalman filter (DCDKF) where two Kalman filters run in parallel to simultaneously estimate vehicle different dynamic states and inertial parameters, such as vehicle sideslip angle, vehicle mass, vehicle yaw moment of inertia, the distance from the front axle to centre of gravity. The proposed estimation method only integrates and utilizes real-time measurements of hub torque information and other in-vehicle sensors from standard DDEVs. The four-wheel nonlinear vehicle dynamics estimation model considering payload variations, Pacejka tire model, wheel and motor dynamics model is developed, the observability of the DCDKF observer is analysed and derived via Lie derivative and differential geometry theory. To address system nonlinearities in vehicle dynamics estimation, the DCDKF and dual extended Kalman filter (DEKF) are also investigated and compared. Simulation with various maneuvers are carried out to verify the effectiveness of the proposed method using Matlab/Simulink-Carsim®. The results show that the proposed DCDKF method can effectively estimate vehicle dynamic states and inertial parameters despite the existence of payload variations and variable driving conditions. This research provides a boot-strapping procedure which can performs optimal estimation to estimate simultaneously vehicle system state and inertial parameter with high accuracy and real-time ability.
Integration of anatomy and physiology into nursing practice as perceived by undergraduate students and registered nurses: a scoping review
Authors: Horiuchi-Hirose Miwa , Fukuoka Tomoko , Saeki Yuka 
Published: August 2023

Abstract
Objective
The current study aimed to determine perceptions of registered and student nurses regarding the integration of anatomy and physiology into nursing practice.

Methods
This scoping review was conducted following the checklist provided in the Reporting Items for Systematic reviews and Meta-Analysis extension for scoping reviews. Articles published in PubMed, ERIC, and CINAL from January 1, 2002 to September 30, 2022 were included.

Results
A literature review of 20 articles that matched the indicative criteria revealed that both undergraduate student and registered nurses recognized knowledge of anatomy and physiology as important to nursing practice. Student nurses recognized that such knowledge is related to understanding patient pathophysiology, patient observation, treatment selection, and patient safety and forms the basis for nursing practice. Registered nurses who were confident in their knowledge of anatomy and physiology also reported that they were able to explain the rationale for their nursing practice. They also reported that this knowledge is necessary for communication with multiple professions, which promotes patient/family trust in nurses and is the basis for building trusting relationships with patients and their families.

Conclusions
Although undergraduate student and registered nurses recognized the importance of learning anatomy and physiology, the integration of anatomy and physiology into nursing practice was not the same for all student and registered nurses. This suggests the need to investigate the overall perceptions of nurses regarding the integration of anatomy and physiology into nursing practice and for faculty to discuss how to facilitate critical thinking among students.
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease
Authors: Sachs Stephan , Götz Anna , Finan Brian , Feuchtinger Annette , DiMarchi Richard D. , Döring Yvonne , Weber Christian , Tschöp Matthias H. , Müller Timo D. , Hofmann Susanna M. 
Published: August 2023

Abstract
Background
Agonism at the receptor for the glucose-dependent insulinotropic polypeptide (GIPR) is a key component of the novel unimolecular GIPR:GLP-1R co-agonists, which are among the most promising drugs in clinical development for the treatment of obesity and type 2 diabetes. The therapeutic effect of chronic GIPR agonism to treat dyslipidemia and thus to reduce the cardiovascular disease risk independently of body weight loss has not been explored yet.

Methods
After 8 weeks on western diet, LDL receptor knockout (LDLR-/-) male mice were treated with daily subcutaneous injections of long-acting acylated GIP analog (acyl-GIP; 10nmol/kg body weight) for 28 days. Body weight, food intake, whole-body composition were monitored throughout the study. Fasting blood glucose and intraperitoneal glucose tolerance test (ipGTT) were determined on day 21 of the study. Circulating lipid levels, lipoprotein profiles and atherosclerotic lesion size was assessed at the end of the study. Acyl-GIP effects on fat depots were determined by histology and transcriptomics.

Results
Herein we found that treatment with acyl-GIP reduced dyslipidemia and atherogenesis in male LDLR-/- mice. Acyl-GIP administration resulted in smaller adipocytes within the inguinal fat depot and RNAseq analysis of the latter revealed that acyl-GIP may improve dyslipidemia by directly modulating lipid metabolism in this fat depot.

Conclusions
This study identified an unanticipated efficacy of chronic GIPR agonism to improve dyslipidemia and cardiovascular disease independently of body weight loss, indicating that treatment with acyl-GIP may be a novel approach to alleviate cardiometabolic disease.
The impact of patient navigation on glycemic control, adherence to self-care and knowledge about diabetes: an intervention study
Authors: Foppa Luciana , Nemetz Betina , de Matos Rosimeri , Schneiders Josiane , Telo Gabriela Heiden , Schaan Beatriz D. 
Published: August 2023

Abstract
Background
Patient navigation helps with better adherence to treatment, as well as better knowledge about diabetes and greater interest in performing, monitoring, and seeking health care. Therefore, this study aims to evaluate the effect of patient navigation on glycemic control, disease knowledge, adherence to self-care in people with type 1 diabetes mellitus.

Methods
This is an intervention study using a single group pre-test post-test design, carried out in a tertiary public teaching hospital in Southern Brazil. Participants over 18 years of age and diagnosed with type 1 diabetes were included. In total, three teleconsultations and one face-to-face consultation were carried out, with three-month intervals, until completing one year of follow-up. The nurse navigator conducted diabetes education based on the guidelines of the Brazilian Diabetes Society and the Nursing Interventions Classification. The differences between glycated hemoglobin, adherence to self-care, and knowledge about initial and final diabetes were estimated to verify the effect of patient navigation by nurses, according to the tool applied in the first and last consultations. Interaction analyses between variables were also performed. Student’s t-test, Generalized Estimating Equations, Wilcoxon test, and McNemar test were used.

Results
The final sample consisted of 152 participants, of which 85 (55.9%) were women, with a mean age of 45 ± 12 years, and diabetes duration of 23.6 ± 11.1 years. Nurse navigators conducted 812 teleconsultations and 158 face-to-face consultations. After the intervention, glycemic control improved in 37 (24.3%) participants (p < 0.001), and knowledge about diabetes also improved in 37 (24.3%) participants (p < 0.001). Adherence to self-care increased in 82 (53.9%) patients (p < 0.001). The analysis of the interaction between glycemic control and the results from the questionnaire of knowledge about diabetes showed an interaction effect (p = 0.005). However, we observed no interaction effect between glycemic control and the results from the questionnaire on adherence to self-care (p = 0.706).

Conclusions
Our results showed improvement in glycemic control, adherence to self-care, and knowledge of diabetes in the study participants. In addition, they suggest that patient navigation performed by nurses is promising and feasible in improving care for patients with type 1 diabetes.
Clinical Neurobiology of Sleep and Wakefulness
Authors: Castillo Pablo R. 
Published: August 2023

ABSTRACT

Objective
This article focuses on novel neuronal mechanisms of sleep and wakefulness and relates basic science developments with potential translational implications in circadian neurobiology, pharmacology, behavioral factors, and the recently integrated potential pathways of sleep-related motor inhibition.

Latest Developments
During the past decade, remarkable advances in the molecular biology of sleep and wakefulness have taken place, opening a promising path for the understanding of clinical sleep disorders. Newly gained insights include the role of astrocytes in sleep brain homeostasis through the glymphatic system, the promotion of memory consolidation during states of reduced cholinergic activity during slow wave sleep, and the differential functions of melatonin receptors involving regulation of both circadian rhythm and sleep initiation. Ongoing investigations exploring sleep and circadian rhythm disruptions are beginning to unlock pathophysiologic aspects of neurologic, psychiatric, and medical disorders.

Essential Points
An understanding of sleep and circadian neurobiology provides coherent and biologically credible approaches to treatments, including the identification of potential targets for neuromodulation.
Intestinal dysbiosis in heart failure - modulation of dysbiosis as a potential therapeutic target
Authors: Osiak Joanna , Wołowiec Łukasz , Żukow Xawery , Fydrych Dagmara , Jasniak Albert , Gawłowska Kinga , Staniewska Agata , Grześk Grzegorz 
Published: August 2023

The last decade has provided extensive information on the human gut microbiota. The microorganisms populating the gastrointestinal tract play important roles in maintaining the body's homeostasis. It turns out that the intestinal microbiota can affect many diseases from various branches of medicine. The importance of the function of the microflora can also affect cardiovascular diseases (CVD), including heart failure (HF). The microflora influences among other things, nutrient digestion, vitamin production or the production of bioactive metabolites including trimethylamine/trimethylamine N-oxide, short-chain fatty acids and bile acids. Therefore, changes in the composition of the intestinal microflora, defined as dysbiosis, have become one of the key pathogenic factors in many diseases. There is emerging evidence of a strong correlation between gut microflora and the occurrence of cardiovascular disease. In patients with cardiovascular disease and corresponding risk factors, the composition and proportions of the intestinal microflora differed significantly from healthy subjects.
Differences in microbial composition and marked fluctuations in the levels of biomarkers such as TMAO, zonulin, LPS, SCFAs may become helpful in the diagnosis of cardiovascular diseases. For this reason, the intestinal microflora and its metabolic pathways have recently become the subject of numerous studies. A very important issue is the fact that it is possible to regulate the intestinal microflora through diet, the use of prebiotics, probiotics or influence through a much larger intervention - for example, fecal mass transplantation. These possibilities have become new strategies in the treatment of HF. The main purpose of this review is to summarize recent studies that illustrate the complex interactions between the microbiome and the occurrence of HF.
Conclusions. The gut microbiota is a complex ecosystem of microorganisms that live in the human gut. The gut microbiota plays an important role in maintaining the body's health, including the cardiovascular system. Dysbiosis, or an imbalance in the gut microbiota, has been linked to the development of heart failure. Gut microbiota metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and bile acids, can have harmful effects on the heart. Diet, probiotics, and fecal microbiota transplantation (FMT) are all potential interventions for improving gut microbiota and reducing the risk of heart failure. More research is needed to fully understand the role of gut microbiota in heart failure and to develop effective treatment strategies.