bluuebunny/crossref_metadata_2025_split huggingface dataset:
CADORmed: a tool for internal dose assessment
Authors: Landry Bernard , Breustedt Bastian , Castellani Carlo Maria , Lopez Maria Antonia , Sierra Inmaculada , Navarro Juan Francisco , Roberts Gareth 
Published: March 2023

Abstract
CADORmed is a free bespoke Excel® tool for committed effective dose assessment using latest dose coefficients from ICRP OIR publications. The field of application of CADORmed is special monitoring, and it is not available for the dose assessment of chronic exposure. Calculations are made according to EURADOS guidelines and principles (EURADOS report 2013-1). The Chi-squared test for the goodness of fit is made with a scattering factor for type A and type B errors according to the EURADOS report. The Intake is calculated with the maximum likelihood method. Measurements that are below the detection limit are incorporated by the use of an allocated value equal to one-half or one-quarter of the detection limit. The Identification of rogue data can easily be achieved. Advanced options may also be used: mixed ingestion and inhalation, mixture of default absorption types, correction for DTPA treatment, calculation with a new intake and adjustment when the date of intake are unknown. The validation of the tool has been included in the work plan of EURADOS WG 7. The validation plan has been defined and the validation tests completed. All changes are traced in a Quality Assurance document.
Radiation monitoring after experimental dirty bomb explosion
Authors: Kozlovska Michaela , Sybkova Hana , Otahal Petr PS 
Published: March 2023

Abstract
Experiments simulating radioactive dirty bomb explosions in an urban area were performed at the National Institute of NBC Protection (SUJCHBO v.v.i.), Czech Republic. A solution containing 99mTc radionuclide was dispersed by an explosion on an open-air model of a square covered with filters. Subsequently, spectra of gamma rays originating in contaminated filters were measured by a hand-held NaI(Tl) spectrometer and laboratory HPGe spectrometers. The ambient dose equivalent rate at measuring vessels was set as well. Self-made standards had been prepared by dripping a defined amount of 99mTc solution uniformly on the filters to set the 99mTc surface contamination of measured samples. The urban area model’s radioactive contamination map was set using previously determined filters’ locations. The defined amount of 99mTc solution was dripped non-homogenously on some filters to estimate the impact of non-homogenous filters’ coverage by radioactive aerosol’ particles.
Intercomparison study of sensitivities from commercial OSL readers and a newly developed OSL reader
Authors: de Lazzari Rodrigo , Souza Edgar H , Zanetti Susan Y , Viana Emilson R , Malthez Anna LMC 
Published: March 2023

Abstract
In this study, we compared the sensitivities of a newly designed OSL system with two commercial systems, performing OSL readouts of Al2O3:C irradiated with doses ranging from mGy to a few Gy. It is our first prototype, and we used a cluster of three blue LEDs (5 W each and approximately wavelength 450 nm) for the optical stimulation in the modes continuous wave (CW-OSL) and pulsed (POSL). The detection window used a bandpass filter, allowing the detection of OSL signal with a wavelength shorter than 360 nm. For detection, we have a photodetector module with a photomultiplier tube. We compared the readouts with commercial readers, respecting each reader’s different characteristics, which present different wavelengths for optical stimuli (blue and green, respectively) in CW-OSL and POSL modes. The obtained results concluded that the developed reader could be applied for OSL readouts of detectors exposed to a few hundred of mGy in POSL mode and high doses (up to a few Gy) in CW-OSL mode.
Radiosurgery dosimetry using CaSO4:Eu OSLD film—a feasibility study
Authors: Gasparian Patricia BR , Malthez Anna LMC , Torquato Michele , Campos Leticia L 
Published: March 2023

Abstract
Recent studies demonstrated that optically stimulated luminescence (OSL) systems allow the evaluation of doses for 2D mapping in a relatively fast and simple way and results show submillimeter resolution. This work presents, for the first time, an optically stimulated luminescence dosemeter (OSLD) in the form of film made with CaSO4:Eu particles embedded in a silicone elastomer matrix. The OSLD film was produced using a low-cost and relatively simple methodology. This film is reusable and the signal can be satisfactorily bleached using blue LEDs. The main dosimetric properties were evaluated using TL/OSL Risø reader with blue stimulation and Hoya U-340 filter. Investigation shows repeatability within 3% when measuring with the same film sample. Regarding the OSLD film homogeneity, nearly 12% sensitivity change was observed within the 5 × 5 cm2 produced film. Additionally, the dose response curve shows linearity from 5 to 25 Gy. Fading of the OSL signal is relatively high, about 50% in the first week and then is stable. Nevertheless, a 3 × 3 cm2 OSLD film was successfully used to map dose distribution in radiosurgery (6 MV photon beam). This work demonstrates the feasibility of 2D dosimetry using reusable OSLD films based on CaSO4:Eu.
Engaging Stakeholders to Adapt an Evidence-Based Family Healthy Weight Program
Authors: Darling Katherine E , Hayes Jacqueline F , Evans E Whitney , Sanchez Irene , Chachra Jessica , Grenga Andrea , Elwy A Rani , Jelalian Elissa 
Published: March 2023

Abstract
Childhood obesity is associated with negative physical and psychosocial outcomes, especially for children from low-income backgrounds. It is critical to adapt evidence-based family healthy weight programs to meet the needs of this population. The Framework for Reporting Adaptations and Modifications to Evidence-Based Interventions was used to describe the process of using qualitative data from community and intervention stakeholders, children with overweight or obesity from low-income backgrounds, and caregivers to guide adaptations to the JOIN for ME pediatric weight management intervention. Qualitative interviews were conducted with key community and intervention stakeholders (e.g., nurse care managers, prior JOIN for ME coaches; N = 21). Focus groups were conducted in both Spanish and English with children with overweight or obesity from low-income backgrounds (N = 35) and caregivers of children with overweight or obesity from low-income backgrounds (N = 71). Qualitative data analysis informed modifications including content adaptations to simplify and tailor materials, contextual adaptations to improve intervention engagement and framing, resource awareness, and modality of delivery, training adaptations, and implementation/scale-up activities to increase connections with community partners. The process of engaging multiple stakeholder perspectives to tailor an existing intervention can provide a model for future researchers to improve the potential disseminability of an intervention.
Urinary L-Type Fatty Acid-Binding Protein Predicts Oxygen Demand of COVID-19 in Initially Mild Cases
Authors: Katagiri Daisuke , Asai Yusuke , Ohmagari Norio , Ishikane Masahiro , Hikida Sayaka , Iwamoto Noriko , Nagashima Maki , Suzuki Minami , Takano Hideki , Takasaki Jin , Hojo Masayuki , Sugiyama Haruhito , Tokunaga Katsushi , Miyashita Yoshihiro , Omata Masao , Ohata Keiichi , Bliden Kevin P. , Tantry Udaya S. , Dahlen Jeffrey R. , Sugaya Takeshi , Gurbel Paul A. , Noiri Eisei 
Published: March 2023

IMPORTANCE:
Early detection of illness trajectory in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected patients is crucial for patients and healthcare workers. An effective, noninvasive approach, with simple measurement for decision-making, is necessary in a pandemic to discriminate between high- and low-risk patients, even though both groups may exhibit mild symptoms in the beginning.

OBJECTIVES:
To predict COVID-19 disease severity within 10 days, distinguishing cases that will progress to moderate or severe versus mild, patient urinary L-type fatty acid-binding protein (L-FABP) was assayed within 4 days of receiving a diagnosis. The study also examined whether L-FABP point of care (POC) test is helpful in risk screening.

DESIGN:
Symptomatic subjects who tested positive for SARS-CoV-2 and were hospitalized were prospectively enrolled at the National Center for Global Health and Medicine (NCGM), Yamanashi Prefectural Central Hospital (YPCH), and Sinai Hospital in Maryland. The outcome of each case was evaluated 7 days after admission and the diagnostic performance of L-FABP was assessed.

SETTING AND PARTICIPANTS:
Subjects were treated for COVID-19 at public healthcare centers in Japan from January 31, 2020, to January 31, 2021, to NCGM, YPCH, and at Sinai Hospital in Baltimore, MD, during the same period.

MAIN OUTCOMES AND MEASURES:
The primary outcome was to determine whether urinary L-FABP within 48 hours of admission can predict the patient’s severity of COVID-19 1 week later. We obtained demographic data, information on clinical symptoms, radiographic images, and laboratory data.

RESULTS:
Diagnostic performance was assessed using receiver operating characteristic analysis. Of the 224 participants in the study, 173 initially had a mild form of COVID-19. The area under the curve (AUC) for a severe outcome was 93.5%. L-FABP POC risk prediction of a severe outcome had an AUC of 88.9%.

CONCLUSIONS AND RELEVANCE:
Urinary L-FABP can predict patient risk of COVID-19 illness severity. L-FABP POC is implementable for patient management. (ClinicalTrials.gov number, NCT04681040).
Dermabrasion Versus Microneedling in Transplantation of Autologous Noncultured Melanocyte–Keratinocyte Cell Suspension in Patients With Vitiligo
Authors: Hasan Mohamed S. , Almohsen Abdelraouf M. , Nasr Muhammad I. , Rageh Mahmoud A. 
Published: March 2023

BACKGROUND
Autologous noncultured melanocyte–keratinocyte transplantation is one of the procedures used to treat stable vitiligo with varying reported results. Recipient site preparation is one of the variables that could affect repigmentation outcomes.

OBJECTIVE
To assess the effectiveness of transplanting autologous melanocyte–keratinocyte suspension in patients with stable vitiligo and to compare recipient site preparation using dermabrasion versus microneedling.

METHODS
From March 2020 to September 2022, this randomized comparative study included 40 patients with 40 stable vitiligo lesions managed by suspension transplants of melanocytes. Patients were divided into 2 groups: group A, where the recipient site was prepared using dermabrasion, and group B, which was done by microneedling. The assessment was performed 3 months after the treatment based on the degree of repigmentation (excellent, ≥90%; good, 50%–89%; fair, 20%–49%; and poor response, <20%).

RESULTS
Both modalities resulted in effective repigmentation, but the dermabrasion group showed a statistically significant improvement and a satisfactory repigmentation rate.

CONCLUSION
Autologous melanocyte transplantation is a safe and effective treatment method for stable vitiligo lesions that have not responded to other therapies. When compared with microneedling, dermabrasion produced better outcomes for recipient site preparation.
Benefits of Cardiac Rehabilitation in Cardio-Renal Patients With Heart Failure With Reduced Ejection Fraction
Authors: Mroué Ahmad , Roueff Stéphane , Vanorio-Vega Isabella , Lazareth Hélène , Kovalska Oksana , Flahault Adrien , Tuppin Philippe , Thervet Eric , Iliou Marie-Christine 
Published: March 2023

Purpose:
Chronic kidney disease (CKD) is common in heart failure (HF). Chronic kidney disease often worsens the prognosis and impairs the management of patients with HF. Chronic kidney disease is frequently accompanied by sarcopenia, which limits the benefits of cardiac rehabilitation (CR). The aim of this study was to evaluate the impact of CR on cardiorespiratory fitness in HF patients with reduced ejection fraction (HFrEF) according to the CKD stage.

Methods:
We conducted a retrospective study including 567 consecutive patients with HFrEF, who underwent a 4-wk CR program, and who were evaluated by cardiorespiratory exercise test before and after the program. Patients were stratified according to their estimated glomerular filtration rate (eGFR). We performed multivariate analysis looking for factors associated with an improvement of 10% in peak oxygen uptake (V˙o
2peak).

Results:
Thirty-eight percent of patients had eGFR <60 mL/min/1.73m². With decreasing eGFR, we observed deterioration in V˙o
2peak, first ventilatory threshold (VT1) and workload and an increase in brain natriuretic peptide levels at baseline. After CR, there was an improvement in V˙O
2peak (15.3 vs 17.8 mL/kg/min, P < .001), VT1 (10.5 vs 12.4 mL/kg/min, P < .001), workload (77 vs 94 W, P < .001), and brain natriuretic peptide (688 vs 488 pg/mL, P < .001). These improvements were statistically significant for all stages of CKD. In a multivariate analysis predicting factors associated with V˙o
2peak improvement, renal function did not interfere with results.

Conclusions:
Cardiac rehabilitation is beneficial in patients with HFrEF with CKD regardless of CKD stage. The presence of CKD should not prevent the prescription of CR in patients with HFrEF.
VALSALVA RETINOPATHY
Authors: Rohowetz Landon J. , Patel Veshesh , Sridhar Jayanth , Yannuzzi Nicolas A. 
Published: March 2023

Purpose:To report the clinical presentation and outcomes in patients with Valsalva retinopathy.Methods:This was a retrospective case series of patients diagnosed with Valsalva retinopathy between June 1, 2010, and May 31, 2020. Clinical notes, operative reports, fundus photography, and optical coherence tomography images were reviewed.Results:This study comprised 58 eyes of 58 patients. The most common causes were lifting (34.4%), vomiting (20.6%), straining (20.6%), and coughing (17.2%). Mean best-corrected visual acuity at diagnosis was 20/163. The most frequently involved vitreoretinal compartment was the subhyaloid space (42.3%) followed by the intraretinal (32.7%), intravitreal (23.1%), and subretinal (13.4%) spaces. Mean best-corrected visual acuity of all patients was 20/59 at 3 months, 20/48 at 6 months, and 20/22 at 1 year. Mean time to clearance of hemorrhage on clinical examination was 99.0 ± 18.7 days in patients who underwent observation and 4.5 ± 3.5 days after surgery in patients who received pars plana vitrectomy.Conclusion:Valsalva retinopathy is generally associated with a favorable visual prognosis. Most eyes perform well with observation although pars plana vitrectomy may be indicated in patients requiring rapid resolution of hemorrhage.
Predictability of the Phenylephrine Test in Congenital Ptosis: Ten Years of Experience
Authors: Akella Sruti S. , Srivatsan Sudarshan , Kravets Sasha , Setabutr Pete 
Published: March 2023

Purpose:
To assess the predictability of phenylephrine testing for congenital ptosis and review outcomes of Müller’s Muscle-conjunctival resection (MMCR) for congenital ptosis across ten years of follow-up.

Methods:
In this retrospective case series, all patients who underwent MMCR for congenital ptosis at a single institution between 2010 and 2020 were identified. Exclusion criteria included patients who had not undergone preoperative testing with 2.5% phenylephrine in the superior fornix; patients who underwent revision surgery; and patients who had a broken suture in the early postoperative period. Demographics, margin-reflex distance 1 (MRD1) values pre- and postphenylephrine, millimeters of tissue resected intraoperatively, and final postoperative MRD1 were recorded.

Results:
A total of 28 patients were included; 19 patients received MMCR and 9 patients received a combined MMCR plus tarsectomy. The amount of tissue resected ranged from 5 to 11 mm. There was no significant difference between median postphenylephrine MRD1 and median final postoperative MRD1 in either surgical group. Neither patient age nor levator function was significantly associated with a change in MRD1 in either group. The addition of a tarsectomy had no bearing on the final MRD1 value.

Conclusions:
MMCR is a viable option for patients with congenital ptosis and moderate levator function with a response to phenylephrine. In these patients, MRD1 after 2.5% phenylephrine testing correlates to the final postoperative MRD1 outcome within 0.5 mm.
Evidence-Based Performance Indicators of Positive Inpatient Experiences
Authors: Kemp Elyria , Trivitt Julie , Davis Cassandra 
Published: March 2023

Goal:
Patient experiences affect the competitiveness and financial viability of a hospital. The purpose of this research was to ascertain the factors that contribute to positive inpatient experiences by using empirical evidence from national databases and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey data.

Methods:
Data were assembled from four publicly available U.S. government datasets. The HCAHPS national survey responses (n = 2,472) were based on four consecutive quarters of patient surveys. Measures of clinical complications obtained from the Centers for Medicare & Medicaid Services were used to assess hospital quality. Social determinants of health were incorporated into the analysis by including data from the Social Vulnerability Index as well as zip code–level information from the Office of Policy Development and Research.

Principal Findings:
The study results show that hospital quietness, nurse communication, and care transition positively affected patient experience ratings and the patient's likelihood to recommend the hospital. In addition, findings show that hospital cleanliness positively influenced patient experience ratings. However, hospital cleanliness had little impact on the likelihood of a patient's recommending the hospital, and staff responsiveness had a negligible impact on both patient experience ratings and the likelihood to recommend the hospital. The results also revealed that hospitals with better clinical outcomes received better patient experience ratings and recommendation scores, whereas hospitals that serve more vulnerable populations received worse patient experience ratings and recommendation scores.

Practical Applications:
Findings from this research demonstrate that managing the physical surroundings by providing a clean and quiet environment, providing relationship-centered care through interactions with medical personnel, and working to engage patients in their health as they transition out of care contributed to positive inpatient experiences.
Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers
Authors: Fazen Louis E. , Abad Queenie-Ann , Smith Richard F. , Santiago Romero , Liu Jian , Wisnewski Adam V. , Redlich Carrie A. 
Published: March 2023

ObjectiveThe aim of the study is to evaluate COVID-19 risk factors among healthcare workers (HCWs) before vaccine-induced immunity.MethodsWe conducted a longitudinal cohort study of HCWs (N= 1233) with SARS-CoV-2 immunoglobulin G quantification by ELISA and repeated surveys over 9 months. Risk factors were assessed by multivariable-adjusted logistic regression and Cox proportional hazards models.ResultsSARS-CoV-2 immunoglobulin G was associated with work in internal medicine (odds ratio [OR], 2.77; 95% confidence interval [CI], 1.05–8.26) and role of physician-in-training (OR, 2.55; 95% CI, 1.08–6.43), including interns (OR, 4.22; 95% CI, 1.20–14.00) and resident physicians (OR, 3.14; 95% CI, 1.24–8.33). Odds were lower among staff confident in N95 use (OR, 0.55; 95% CI, 0.31–0.96) and decreased over the follow-up.ConclusionsExcess COVID-19 risk observed among physicians-in-training early in the COVID-19 pandemic was reduced with improved occupational health interventions before vaccinations.
Role of gastric ultrasound to guide enteral nutrition in the critically ill
Authors: Pérez-Calatayud Ángel Augusto , Carillo-Esper Raul 
Published: March 2023

Purpose of review
Early initiation of enteral nutrition (EN) is often not feasible due to the high prevalence of gastrointestinal dysfunction that constitutes one of the leading nonavoidable causes for discontinuing or delaying enteral feeding in critically ill. This review summarizes current evidence on the role of gastric ultrasound as a management and monitoring tool for enteral nutrition in critically ill patients.

Recent findings
The ultrasound meal accommodation test, the gastrointestinal and urinary track sonography (GUTS), and other gastric ultrasound protocols used to diagnose and treat gastrointestinal dysfunction in critically ill patients have not changed the outcome. However, this intervention could help clinicians with accurate daily clinical decisions. The dynamic changes in the cross-sectional area (CSA) diameter could help to access gastrointestinal dynamics results immediately, provide a valuable guide to initiate EN, predict feeding intolerance (FI), and aid in following treatment response. More studies are necessary to determine the complete scope and true added clinical value of these tests in critically ill patients.

Summary
Using gastric point of care ultrasound (POCUS) is a noninvasive, radiation-free, and inexpensive method. Implementing the ultrasound meal accommodation test in ICU patients might become a step forward to ensure safe early enteral nutrition in critically ill patients.
Physical therapy and nutrition therapy: synergistic, antagonistic, or independent interventions?
Authors: Haines Kimberley J. , Emery Kate L. , Berney Sue C. 
Published: March 2023

Purpose of review
Physical therapy and nutrition therapy have predominantly been studied separately in the critically ill, however in clinical practice are often delivered in combination. It is important to understand how these interventions interact. This review will summarize the current science – where they are potentially synergistic, antagonistic, or independent interventions.

Recent findings
Only six studies were identified within the ICU setting that combined physical therapy and nutrition therapy. The majority of these were randomized controlled trials with modest sample sizes. There was an indication of benefit in the preservation of femoral muscle mass and short-term physical quality of life - particularly with high-protein delivery and resistance exercise, in patients who were predominantly mechanically ventilated patients, with an ICU length of stay of approximately 4–7 days (varied across studies). Although these benefits did not extend to other outcomes such as reduced length of ventilation, ICU or hospital admission. No recent trials were identified that combined physical therapy and nutrition therapy in post-ICU settings and is an area that warrants investigation.

Summary
The combination of physical therapy and nutrition therapy might be synergistic when evaluated within the ICU setting. However, more careful work is required to understand the physiological challenges in the delivery of these interventions. Combining these interventions in post-ICU settings is currently under-investigated, but may be important to understand any potential benefits to patient longitudinal recovery.