bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nobiletin attenuates Nrf2-Gpx4-regulated ferroptosis in septic liver injury by modulating the gut microbiota
Authors: Huang Wei , Chen Hui , He Qi , Xie Weidang , peng Zanlin , Ma Qiang , Huang Qiaobing , Chen Zhongqing , Liu Yanan 
Published: February 2023

AbstractBackground Nobiletin (NOB), a plant-based polymethoxyflavone, has been shown to be a promising protective agent against sepsis; yet the mechanisms were not fully elucidated. The gut microbiota is found to be strongly associated with sepsis-associated acute liver injury (SALI). Here, our study aimed to determine whether these protective effects of NOB against SALI were related to modulations in the gut microbiota. Methods Cecal ligation and puncture (CLP) was used to induce SALI in mice. NOB therapy by gavage (50 mg/kg/day) was administrated for 7 days before CLP treatment. The 16S rRNA gene sequencing and fecal microbiota transplantation (FMT) were performed to explore the function of gut microbiota in SALI mice. Markers of ferroptosis, inflammation, gut microbiota composition, and liver injury were determined. Results NOB administration significantly alleviated hepatic ferroptosis and inflammation in septic mice. Meanwhile, NOB upregulated nuclear factor E2-related factor 2 (Nrf2) and its downstream proteins heme oxygenase-1 (HO-1) expression levels in the liver. Nrf2 inhibitor ML385 significantly eradicated NOB administration decreased hepatic ferroptosis in SALI mice. Additionally, increased abundances ofLigilactobacillus,Akkermansia, andLactobacillus, and decreased abundances ofDubosiellaandBacteroidesin the gut were observed under NOB treatment, suggesting that NOB ameliorated SALI-induced microbial dysbiosis. Furthermore, gut microbiota ablation by antibiotic treatment partly eradicated NOB administration decreased hepatic ferroptosis and activated Nrf2 signaling in SALI mice, suggesting NOB inhibited ferroptosis and activated Nrf2 signaling in SALI mice by modulating gut microbiota. Moreover, transplantation of the NOB-microbiota to microbiota-depleted mice was sufficient to decreased hepatic ferroptosis, inflammation, and activated Nrf2 signaling in the liver. Conclusions We have shown that NOB attenuates Nrf2-Gpx4-regulated ferroptosis in septic liver injury by modulating the gut microbiota. Of note, NOB might be employed as a potential therapeutic agent for sepsis treatment. Our findings also provide novel insights into microbiome-based therapeutic approaches for sepsis.
Incidence and risk factors of postoperative sleep disorders in patients with malignancy after radical surgery
Authors: Wang Zihan , Zhang Yu , Xu Kaiwei , Fu Haifeng , Yan Yixiu , Du Wenwen 
Published: February 2023

Abstract
Purpose
This prospective cohort study was designed to evaluate the incidence of and identify the risk factors associated with sleep disorders in patients with cancer following radical surgery.
Methods
In total, 297 patients with cancer underwent elective radical surgery in the Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, between October 2020 and December 2021. Patients were divided into two groups according to a Pittsburgh Sleep Quality Index (PSQI) score ≥ 8: a sleep-disorder group and no-sleep-disorder group. Data pertaining to preoperative, intraoperative, and postoperative risk factors were recorded. Logistic regression analysis was conducted to explore the risk factors associated with sleep disorders in this patient population.
Results
The prevalence of postoperative sleep disorders in patients with cancer after radical surgery was 63.64%. The preoperative PSQI score, postoperative sleep apnoea syndrome (SAS) score, tumour type, moderate and severe postoperative pain, remaining in confined spaces, and education level were significantly associated with postoperative sleep disorders. The area under the curve was 0.87.
Conclusions
We should pay attention to patients with cancer who have undergone radical surgery and have higher preoperative PSQI scores, postoperative SAS scores, moderate and severe postoperative pain, higher education level, and remain in confined spaces. A multimodal approach including preoperative education, postoperative multimodal analgesia, improvement of the environment, and use of some medication types could improve transient sleep disturbances in patients with cancer after radical surgery.
"Management of neonatal pulmonary hypertension – a survey of neonatal intensive care units in India”
Authors: Singh Pari , Deshpande Sujata , Nagpal Rema , Garegrat Reema , Gupta Samir , Suryawanshi Pradeep 
Published: February 2023

Abstract
Background: Persistent pulmonary hypertension of the newborn (PPHN) is a common neonatal condition associated with significant morbidity and mortality. First-line diagnostic and treatment options such as echocardiography and inhaled nitric oxide (iNO) are not routinely available in resource limited settings and alternative treatment modalities need to be utilized. This study was conducted to assess current diagnostic and management strategies used for PPHN in Indian neonatal intensive care units (NICUs).
Methods: A questionnaire in multiple choice question format was sent to practising neonatologists in India via an online survey tool between July to August 2021. Information pertaining to demographic data, diagnostic criteria and management strategies of PPHN was requested. The responses were collated and information processed.
Results: There were 118 respondent NICUs (response rate 74%). The majority of neonatal units (65%) admitted an average of 1-3 patients of PPHN per month. Targeted neonatal echocardiography (TnECHO) was practised in 80% of the units. Most common management strategies being followed were pulmonary vasodilators (88.1%), inotropes (85.6%), conventional ventilation (68.6%) and high frequency ventilation (59.3%). The most preferred pulmonary vasodilator was sildenafil (79%) and inotropic agent was milrinone (32%). Only 25% of respondents reported use of iNO. None of the participating units used extracorporeal membrane oxygenation.
Conclusion: We found wide variability in management practices of PPHN across Indian NICUs. Non-selective pulmonary vasodilators are more widely used than iNO. There is an urgent need for structured TnECHO training programs and evidence based national guidelines for standardized management of PPHN as per availability of resources in India. Additional research on low cost alternative therapies to iNO in Indian settings might be helpful.
Real-time UAV (Unmanned vehicle) Tracking with Autonomous Drone in Flight
Authors: KAMANLI Ali Furkan 
Published: February 2023

Abstract
In recent years, the use of unmanned aerial vehicle (UAV) platforms in civil and military fields has significantly increased and become a critical technology. The artificial intelligence (AI) embedded UAV system has great importance and potential in the future. Research and development, search and rescue operations, aerial photography, videography, border security, traffic control, forest fire prevention, working in toxic chemical gas environments, preventing poaching, natural resource exploration, agriculture, extraction, and UAV detection while in the air are all applications for AI embedded UAVs.
In this project, Autonomous Drone (Vechür-SIHA) was developed for detecting and tracking other UAVs while in flight sequence. The system was simulated in Robot Operating System (ROS). Inside the simulated environment drone model was used for tracking UAV. After simulations and calculations, the Fighter drone was designed and developed. The real-time UAV detection was made with object detection algorithms inside the simulation and in real-time. The system was embedded with a tracking algorithm based on LSTM (Long-short term memory). The system achieves high-accuracy drone detection in changing backgrounds and weather conditions (%80 accuracy), LSTM drone tracking can be accomplished even with multiple drones inside the field of view, and the system can fly for 35 minutes (Take off and landing included). The system also can be locked other UAVs and track them while in the air. The system can detect and track other UAV's 4-10 seconds without losing contact.
Publication rate of abstracts presented in ConsEuro meetings held between 2003 and 2017: A bibliometric analysis
Authors: Cengiz-Yanardag Esra , Erturk-Avunduk Ayse Tugba , Karakaya Izgen 
Published: February 2023

Abstract
Objectives
This bibliometric study aims to evaluate the publication rates of the abstracts presented at ConsEuro congress between 2003–2017 as well as to determine the factors associated with publication rates.
Materials and Methods
The abstracts presented at 7 ConsEuro meetings held between 2003–2017 were evaluated for subspecialty, study design, number of authors, and the country of the principal investigator’s institution. When the abstract was confirmed as subsequently published, time to publication, the journal in which the abstract was published, impact factor, quartile, 5-year impact factor, index status, SJR of the journal at the publication year and changes in number of authors after publication were determined. Data were statistically analyzed.
Results
Out of 1250 abstracts presented, 445 were published in peer-reviewed journals with a publication rate of 35.6%. The mean duration of time to publication was 26.2 months. The leading journal in terms publication rate was Clinical Oral Investigation. There was no statistically significant difference between the distribution of publication rates by years (p = 0.083). Publication rates of abstracts related to laser therapy, caries and dental materials were statistically higher (p < 0.001) than other subspecialities. Animal, basic and clinical researches were more likely published (p < 0.001).
Conclusions
Less than half of the abstracts in ConsEuro meetings reached full publication. The study design and subspeciality of the researches have an effect on the publication rates which decreases over years.
Clinical Relevance
A considerable amount of scientific data and preliminary results presented in congresses which may contribute to science has been overlooked due to low publication rates.
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia
Authors: Rutten Martijn G.S. , Lei Yu , Hoogerland Joanne H. , Bloks Vincent W. , Yang Hong , Bos Trijnie , Krishnamurthy Kishore A. , Bleeker Aycha , Koster Mirjam H. , Thomas Rachel E. , Wolters Justina C. , Bos Hilda van den , Mithieux Gilles , Rajas Fabienne , Mardinoglu Adil , Spierings Diana C.J. , de Bruin Alain , de Sluis Bart van , Oosterveer Maaike H. 
Published: February 2023

Abstract
Background
Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. Hepatic GSD Ia is characterized by constitutive activation of Carbohydrate Response Element Binding Protein (ChREBP), a glucose-sensitive transcription factor. Previously, we showed that ChREBP activation limits non-alcoholic fatty liver disease (NAFLD) in hepatic GSD Ia. As ChREBP has been proposed as a pro-oncogenic molecular switch that supports tumour progression, we hypothesized that ChREBP normalization protects against liver disease progression in hepatic GSD Ia.
Methods
Hepatocyte-specific G6pc knockout (L-G6pc-/-) mice were treated with AAV-shChREBP to normalize hepatic ChREBP activity.
Results
Hepatic ChREBP normalization in GSD Ia mice induced dysplastic liver growth, massively increased hepatocyte size, and was associated with increased hepatic inflammation. Furthermore, nuclear levels of the oncoprotein Yes Associated Protein (YAP) were increased and its transcriptional targets were induced in ChREBP-normalized GSD Ia mice. Hepatic ChREBP normalization furthermore induced DNA damage and mitotic activity in GSD Ia mice, while gene signatures of chromosomal instability, the cytosolic DNA-sensing cGAS-STING pathway, senescence, and hepatocyte dedifferentiation emerged.
Conclusions
In conclusion, our findings indicate that ChREBP activity limits hepatomegaly while decelerating liver disease progression and protecting against chromosomal instability in hepatic GSD Ia. These results disqualify ChREBP as a therapeutic target for treatment of liver disease in GSD Ia. In addition, they underline the importance of establishing the context-specific roles of hepatic ChREBP to define its therapeutic potential to prevent or treat advanced liver disease.
Evaluation of the danger of a tailings pile belonging to an active mine through its characterization and a dispersion model
Authors: González-Sánchez Jesús Fidel , Mendoza-Lara Osiel Osvaldo , Romero-Hernández Jorge Luis , Fernandez-Villagómez Georgina 
Published: February 2023

Abstract
Mining is one of the principal economic activities in Mexico, which in addition to bringing benefits to the population, causes health and environmental problems. This activity produces many wastes, but the main is tailings. In Mexico, these wastes are disposed of in the open air, and there is no control over them, so the particles of these wastes are dispersed by wind currents to the surrounding population. In this research, tailings were characterized, being these particles smaller than 100 microns; in this way, tailings can enter the respiratory system and thence can cause diseases. Therefore, it is important to characterize these particles and identify the toxic components. The present work shows a qualitative characterization of the tailings from an active mine in Mexico using different analytical techniques. In addition, with the data obtained from the characterization of the tailings, as well as the concentration of the toxic elements found, which were Pb and As, a dispersal model was generated that was used to estimate the concentration of particles in the wind generated by the area study. Environmental Protection Agency (EPA) emission factors were used in the model. The air quality model used in this research is AERMOD, where available databases were used; in addition, the model was coupled with meteorological information from the latest generation WRF model. The modeling results estimated that the dispersion of particles from the tailings dam can contribute up to 10.15 µg/m3 of PM10 to the air quality of the site, which, according to the characterization of the samples obtained, could be dangerous for human health and can be estimated up to a concentration of 0.04 µg/m3 of Pb and 10.90 ng/m3 of As.
Message Transfer with Cosmic Muons
Authors: Tanaka Hiroyuki K.M. 
Published: February 2023

Abstract
Underground and underwater are challenging environments for communication where electromagnetic (EM) waves are strongly attenuated and do not penetrate easily. Very low frequency band signals have long EM wavelengths that can penetrate dense media. However, the base station transmitter for artificially generating long EM wavelengths requires high power consumption for operation; moreover, there are limitations on the types of matter it may pass through. For instance, and the signal cannot penetrate highly conductive materials. In this work, Message transfer to Underground/undersea with COsmic Muons (MUCOM), a slow but robust message transfer method that sends messages from the surface to shallow underground environments regardless of the material type located between the sender and the receiver, are proposed. This communication method is especially suitable under emergency circumstances, for example, it can be used for direct point-to-point message transfer to trapped people or to turn on automated emergency service equipment inside a collapsed subway tunnel. Based on the experimental and numerical analysis, it was found that a detector size of > 1.1–4.5 m2 would be required to attain a data rate higher than 0.01 bps when sending a message from the surface into a typical subway tunnel (at depths of 5–20 m). It is anticipated that MUCOM would be well suited for specific applications such as for sending brief communications to underground locations during accidents or other emergencies.
Incidence and significance of Donor-Specific Antibodies in Haploidentical Stem Cell Transplantation: Single Centre Experience
Authors: Fakih Riad El , Altareb Majed , Al-Awwami Moheeb , Alfraih Feras , Alhayli Saud , Syed Ahmed , Shaheen Marwan , Chaudhri Naeem , Sharif F Al , Alkhabbaz Hana , Albabtain Abdulwahab , Alfayez Mansour , Hanbali Amr , Alshaibani Alfadel , Alotaibi Ahmad , Rasheed Walid , Algharably Amal , Almohareb Fahad , Alahmari Ali , Alzahrani Hazzaa , Aljurf Mahmoud D 
Published: February 2023

Abstract
Background: primary graft failure is a devastating complication after allogeneic transplant. Donor specific antibodies has been reported as a major risk factor contributing to graft failure. We retrospectively analyzed our haploidentical transplant registry to report the incidence and impact of DSA and anti-HLA on engraftment in a cohort of malignant hematologic disease conditioned with myeloablative regimens.
Methods: retrospective analysis of consecutive cases with malignant hematologic disorders who received a myeloablative haplo-HSCT at a single center.
Results: 107 patients were identified with a median recipient age of 22 and a median donor age of 31. Sixty-two patients had AML (58%), 29 had ALL (27%), and 16 (15%) had other malignancies. Sixty-one recipients (57%) had positive anti-HLA, 56 of them had the DSA results available, of these 17 patients had DSAs (15% of the total number of patients, or 28% of patients who have anti-HLA antibodies). The median cumulative MFI was 2062 (IQR: 1038 - 6500). Sixty three percent of the DSA were against class II HLA antigens, while 37% were against class I HLA antigens. The OS, CIR, aGvHD, and cGvHD did not differ between patients with and without anti-HLA antibodies, nor between patients with and without DSA. The gender of the recipient and donor, as well as the gender mismatch between recipient and donor, were statistically associated with the incidence of anti-HLA antibodies, but not with DSA. Three patients only developed GF (2.8%), one was primary (0.9%) and the other two had secondary GF (1.9%). None of the GF cases was in patients with anti-HLA antibodies or DSA.
Conclusion: In our cohort, the presence of anti-HLA or DSAs did not affect the outcomes including the incidence of PGF following myeloablative haplo-HSCT for malignant hematologic disorders.
Tribomechanical Analysis and Machining development for TiSiCN Material Deposited on Industrial Steel
Authors: Caicedo Julio Cesar , Hernandez-Rengifo Erick , Ortíz Christian , Rodríguez Luis Alfredo , Magén Carlos 
Published: February 2023

Abstract
In recent years, nanocomposite coatings have become relevant in different metal-mechanical processes related to the increase of the tribo-mechanical properties. Therefore, this research is focused on improving mechanical behavior and wear resistance of TiSiCN nanocomposite coating with different power applied on the silicon nitride (Si3N4) target by means of Magnetron Sputtering r.f. technique and synthesized on HSS (High-speed-steel) and oriented silicon (100) substrates. The response of the nanocomposite coatings to power variation were analyzed by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM) and instrumented nanoindentation. Ball-On-Disk and Scratch tests were used for tribological characterization. The XRD study determined an FCC structure with a peak of maximum intensity in the plane (200). XPS analysis showed chemical energies in the bonds and stoichiometry. By means of the AFM technique, the tendency to decrease the roughness and grain size were detected, with the increase of the power for the coatings obtained at 500W. From the nanoindentation test, it was possible to stablish increases in mechanical properties as the applied power increases; the best performance was obtained for coating with a 500 W power, where the hardness and elastic modulus were 32 GPa and 301 GPa respectively. The friction coefficient in dry environment decreased with increasing applied power (500 W, 0.31), the critical load produced by adhesive wear was determined for the TiSiCN nanocomposite coatings for the different applied powers, showing the highest critical load in the coating with 500W (62.42 N). Finally, the cutting tests with AISI 1020 steel (workpiece) to assess wear as a function of the applied power. A comparison of the tribological properties revealed a decrease of flank wear (approximately 37%) for ASSAB 17 steel burins coated with TiSiCN nanocomposite coatings with 550 W, when compared to uncoated ASSAB 17 steel burins. These results open a great industrial potential in anti-wear applications.
Prevalence and factors predicting for abnormal multichannel intraluminal impedance-pH monitoring in infants with comorbidities
Authors: Chen Mi-Chi , Yeh Pai-Jui , Lai Ming-Wei , Chen Chien-Chang , Chiu Chih-Yung , Chao Hsun-Chin 
Published: February 2023

Abstract
Infants with history of prematurity, neurological impairment and under critically illness have higher risk of gastroesophageal reflux disease (GERD) and often presented with extraesophageal manifestations. This retrospective study enrolled 79 infants less than 1 year of age (corrected age for prematurity) referred for 24-hour MII-pH monitoring. Prematurity (65.8%), laryngomalacia (46.5%), and neurological impairment (40.5%) were the most common three comorbidities. Abnormal MII-pH monitoring was detected in 39.2% of study subjects, significantly higher in those presenting with esophageal symptom presentation (P = 0.038). Positive pressure ventilation and feeding tube support were significantly associated with less acidic and weakly acidic reflux episodes. Underweight and neurological impairment were identified to be the most important factors for predicting abnormal MII-pH monitoring in overall and extra-esophageal symptom presented infants, respectively. In conclusion, infants presenting with esophageal symptoms or underweight have higher risk of abnormal MII-pH study, whereas extra-esophageal symptoms presented infants comorbid with neurological impairment appear to have normal results. A 24-hour MII-pH study provides a comprehensive evaluation of reflux in the esophagus, determining subsequent anti-reflux therapy or other management strategies for those GER-like symptoms.
Improving the photoelectrochemical water splitting performance of CuO photocathodes using a protective CuBi2O4 layer
Authors: Lam Nguyen Hoang , Truong Nguyen Tam Nguyen , Le Nam , Ahn Kwang-Soon , Jo Younjung , Kim Chan Duk , Jung Jae Hak 
Published: February 2023

Abstract
A heterojunction photocathode of CuO and CuBi2O4 grown on an FTO substrate (FTO/CuO/CuBi2O4) was synthesized using hydrothermal method followed by spin coating and annealing to overcome the bottlenecks encountered by CuO in photoelectrochemical (PEC) water splitting application. The synthesis methods, morphological, structural properties, and composition of each sample under each synthesis condition are discussed in detail. The photocathode with 15 coating layers annealed at 450 °C exhibited the best PEC performance. Moreover, its current density reached 1.23 mA/cm2 under an applied voltage of -0.6 V vs. Ag/AgCl in a neutral electrolyte. Additionally, it exhibited higher stability than the bare CuO thin film. The bonding of CuBi2O4 on CuO resulted in close contact between the two semiconductors, helping the semiconductors support each other to increase the PEC efficiency of the photocathode. CuO acted as the electron-generating layer, and the CuBi2O4 layer helped minimize photocorrosion as well as transport the carriers to the electrode/electrolyte interface to accomplish the hydrogen evolution reaction.