bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colostrum Feeding and Associated Factors Among Mothers Attending Child Immunization Clinic at Public Healthcare Facilities in Dire Dawa City, Eastern Ethiopia
Authors: Gemeda Natnael Dechasa , Muse Yomilan Geneti , Yilma Samson Mesfin , Getie Simegnew Asmer , Alemnew Fentahun , Aweke Amlaku Mulat , Nega Ayenew Tega , Sasiga Teshale Mengesha , Mesfin Firehiwot , Balcha Wondu Feyisa , Hailu Mickiale , Worku Nigus Kassie , Wondie Kindu Yinges , Gera Melaku Laikemariam , Kebede Shambel Abate , Mengesha Tadele 
Published: March 2023

AbstractIntroduction Colostrum is yellow to orange colored milk produced during a first few days of lactation and it is rich in nutrients and antibodies that have great role in health of the new born baby. Despite the world health organization recommends that every new born baby has to feed breast milk with colostrum within one hour of delivery; poor colostrum feeding practice is still a common problem in Ethiopia. Objectives The goal of this study was to assess the practice of colostrum feeding and related factors among women attending a child immunization clinic in governmental health facilities in Dire Dawa City, Eastern Ethiopia, in 2022. Method From February 1–30, 2022, in government health facilities in Dire Dawa city, 292 women with infants less than or equal to 12 months participated in this an institution-based cross-sectional study. Data were gathered by a method of systematic random sampling, and SPSS version 25 was used for analysis. The crude and adjusted odds ratios with a 95% confidence interval were calculated using bivariate and multivariate logistic regression models. A variable was deemed statistically significant if its P value was less than 0.05. Result 68.8% [95% CI: 63.4–74.3] of the moms in our study had good colostrum feeding habits. Living in an urban area [AOR = 2.52, 95% CI = 1.08–5.88], having at least a secondary education [AOR = 2.79, 95% CI = 1.12–6.98], having visited an antenatal clinic in the past [AOR = 3.12, 95% CI = 1.12–9.21], receiving counseling on when to start breastfeeding [AOR = 2.59, 95% CI = 1.02–6.59], receiving colostrum feeding counseling [AOR = 2.65, 95% CI = 1.12–6.30], having a professional attend the birth [AOR = 3.20, 95% CI = 1.23–8.31], getting information from a professional [AOR = 3.89, 95% CI = 1.54–9.82], and having good knowledge of colostrum feeding [AOR = 3.53, 95% CI = 1.56–7.96] were found to be associated with practice of colostrum feeding. Conclusion This study found that women who visit immunization clinics had a low degree of good colostrum feeding practice. Living in an urban area, being educated, having a history of antenatal visits, receiving counseling on when to start breastfeeding, having a professional attend the birth, getting information from a professional, and having a good understanding of colostrum feeding were all linked to the practice of colostrum feeding. To promote mothers' good colostrum feeding habits, prenatal care visits and breastfeeding education should be encouraged.
An artificial neural network for predicting the ultimate bending moments in reinforced concrete beams with fiber-reinforced polymer strengthening
Authors: Hoang Trung Tran Le , Masuya Hiroshi , Kurihashi Yusuke , Minh Tan Trinh 
Published: March 2023

Abstract
A practical artificial neural network tool is proposed for predicting the ultimate bending moments of reinforced concrete beams strengthened by the techniques of externally bonded fiber-reinforced polymer and near-surface mounted fiber-reinforced polymer. Accordingly, the testing database of 131 specimens was gathered for use in developing the artificial neural network model. In this regard, the breadth and height of the beam section, the compression strength of the concrete, the ratio of material reinforcement, and the elastic modulus of fiber reinforced polymer were regarded as input variables, whereas the ultimate bending moment was regarded as an output variable. The performance of the proposed artificial neural network model was compared to the current design model of the American Concrete Institute guide. The comparative analysis demonstrated that the proposed model made more accurate predictions than the current model. Based on the proposed model, a graphical user interface was created to facilitate the prediction of the ultimate bending moments of reinforced concrete beams with fiber-reinforced polymer strengthening.
Efficacy of tranexamic acid supplemented with local infiltration analgesia in reducing blood loss in patients undergoing unicompartmental knee arthroplasty.
Authors: Wiktor Łukasz , Damps Maria , Osadnik Bartłomiej 
Published: March 2023

Abstract
Background: This study aimed to investigate the efficacy of tranexamic acid supplemented with local infiltration analgesia in reducing blood loss in patients undergoing unicompartmental knee arthroplasty (UKA).
Methods: This retrospective study was conducted on 176 individuals with a mean age of 64.27 (standard deviation [SD], 7.16) years undergoing unicompartmental cemented knee arthroplasty. The patients were divided into three groups according to patient blood management: I, patients without additional bleeding protocol (control group); II, patients intravenously administered tranexamic acid (TXA) (TXA group); and III, patients with exact TXA protocol combined with intraoperative local infiltration analgesia (LIA) (TXA + LIA group). Blood loss was measured as a substitute for blood loss by the maximal haemoglobin (Hb) drop compared with the preoperative Hb level.
Results: The mean Hb drops for the control, TXA, and TXA + LIA groups were 2.24 (16.0%), 2.14 (15.4%), and 1.81 (12.6%) g/dl, respectively. The mean hospitalisation days for patients in the control, TXA, and TXA + LIA groups were 5.91 (SD, 1.24), 5.16 (SD, 0.95), and 4.51 (SD, 0.71) days, respectively.
Conclusions: The combination of TXA with LIA reduces perioperative blood loss for patients after UKA.
Customizable Mapping of Virtualized Network Services in Multi-datacenter Environments Based on Genetic Metaheuristics
Authors: Fulber-Garcia Vinicius , Luizelli Marcelo , Santos Carlos Paula dos , Spinosa Eduardo , Duarte Elias 
Published: March 2023

Abstract
One of the major challenges of the Network Functions Virtualization (NFV) paradigm is to properly deploy functions and services across the network. In particular, current solutions for multi-domain service mapping present several restrictions in terms of the choice of optimization models and metrics. This lack of flexibility ultimately leads to sub-optimized mappings that do not meet the (often conflicting) requirements of all the parties involved in the deployment process (e.g., network operators, clients, providers). This work proposes GeSeMa (Genetic Service Mapping), a new intelligent mapping solution based on genetic algorithms. GeSeMa enables flexible configuration of the evaluation setup, which is used to generate candidate mappings. The solution allows the specification of arbitrary optimization metrics, constraints, and different evaluation policies. A genetic algorithm processes mapping requests and iteratively creates/evolves candidate mappings. We evaluate GeSeMa through comprehensive case studies, including a comparison with other classic and state-of-the-art alternatives.
Successful use of HTF as basal fertilization medium during SEcuRe mouse in vitro fertilization
Authors: Wigger Magdalena , Schneider Marco , Feldmann Anni , Assenmacher Sonja , Zevnik Branko , Tröder Simon E. 
Published: March 2023

Abstract
Objective:
The ever-increasing number of genetically engineered mouse models highlights the need for efficient archiving and distribution of these lines. Sperm cryopreservation has become the preferred technique for the majority of these models due to its low requirement of costs, time and experimental animals. Yet, current in vitro fertilization (IVF) protocols either exhibit decreased fertilization efficiency for the most popular C57BL/6 strain, as recently demonstrated by us, or require costly and difficult-to-prepare media, respectively. As a result, we previously developed SEcuRe, a modified IVF protocol with low costs and high fertilization efficiency. The popular basal fertilization medium, Cook’s® proprietary “Research Vitro Fert” (RVF), used in this protocol has recently been discontinued. As a result, the application of the SEcuRe approach has been severely limited.
Results:
Here we show that human tubal fluid (HTF), a popular and widely available medium with a known composition, can be used as basal fertilization medium instead of RVF. Direct comparison of RVF and HTF during SEcuRe IVF of cryopreserved C57BL/6N sperm revealed equal fertilization rates and unaffected developmental capacity of the embryos. In addition, we demonstrate that HTF has a substantially extended shelf-life by utilizing commercial HTF that was six months past its expiration date, yet did not affect fertilization during IVF or subsequent embryo development. This result not only increases the economic value of our modified method, but also validates it once more. Our results demonstrate that common, shelf-life extended HTF can be used in SEcuRe IVF in place of now-discontinued RVF medium and ensure the applicability of the method, which we since termed SEcuRe 2.0. Our modified SEcuRe 2.0 strategy will assist researchers to efficiently archive and distribute genetically engineered mouse models in a cost-effective, easily adaptable, and 3R-compliant manner with minimal animal use.
Pregabalin and Duloxetine versus Celecoxib in Pain Control after Total Knee Arthroplasty. A Randomized Controlled Trial
Authors: Du Ze , Huang Chao , Cao Jian , Zhou Zongke 
Published: March 2023

AbstractBackground Total knee arthroplasty (TKA) is the terminal therapy for knee osteoarthritis (KOA). Long-term postoperative pain is the major complaint in TKA surgery. Nonsteroidal inflammatory drugs (NSAIDs), as the common medicine to treat long-term postoperative pain, have unsatisfactory analgesic effects. Pregabalin and duloxetine work as analgesia medicines, and their exact efficacy on long-term pain after TKA remains elusive. Methods This is a monocentral, open-label randomized clinical trial. KOA participants aged above 50 years old with surgical plans were recruited in January 2022. Eligible participants were randomized 1:1:1 to the standard, pregabalin, and duloxetine groups through a computer dynamic randomization approach. After TKA, the involved participants received study medicine according to their group and were measured 2, 4, and 12 weeks after the start of the study medicine treatment. Results In week 2, there were significant differences in the pressure pain thresholds (PPTs) of the operated knee (P < 0.001) among the three groups. At week 4, there were significant differences in visual pain score (VAS) (P < 0.001), operated knee PPTs (P < 0.001), and hospital for special surgery (HSS) score (P = 0.010) among the three groups. At week 12, there were significant differences in the operated knee PPTs (P < 0.001) and HSS scores (P = 0.009) among the three groups. Five participants in the duloxetine group and 2 participants in the standard group reported AEs. Conclusions Pregabalin and duloxetine were able to reduce both pain and pain sensitivity and improve joint function after TKA compared with celecoxib. Clinical trial registration No. ChiCTR2200056163.
Bark of Protium tenuifolium Engl from the Amazonian biome as a source of phenolic extracts with antioxidant properties
Authors: santos Laise de jesus dos , Araujo Elesandra da Silva , Lorenço Mário Sérgio , Rosário Bianca Bueno , Vieira Sabrina Benmuyal , Sales Agust , Siviero Marco Antonio , Melo Luiz Eduardo de Lima , Mota Graciene da Silva , de Oliveira Gabriela Aguiar , Mori Fabio Akira 
Published: March 2023

Abstract
This study evaluated the anatomical and chemical components of the bark of Protium tenuifolium, a tree species from the Brazilian Amazon, to provide information supporting its value in various industries as a source of polyphenols and natural antioxidants. The bark anatomy was analysed, as was the overall chemical composition (extractives, lignin, suberin, ash and polysaccharides), and a quantitative elemental analysis was performed of the bark and two tannin extracts (extracted with water only and with a mixture of water and Na2SO3). The phenolic composition and antioxidant activity of the bark extracts were quantified. The results indicated that the bark is composed of conductive phloem, nonconductive phloem and rhytidome. The average chemical composition was 15.9% extractives, 35.3% total lignin, 1.9% suberin, 15.4% ash and 31.5% polysaccharides. The condensed tannin yield in the extract obtained with water alone was 5.1%, and that in the treatment with water and Na2SO3 was 8.1%. The ethanol-water extract had a high phenolic content (112.6 mg GAE g-1 extract). The bark extract showed strong antioxidant activity, reaching 83.5% inhibition of DPPH free radicals, which was higher than the value of 75.0% for the commercial antioxidant BHT at the same concentration. These results demonstrate that Protium tenuifolium is a potential natural Amazonian source of phenolic compounds and antioxidants and can be used for medicinal purposes and the production of various sustainable products, such as cosmetics. The extraction of these compounds adds substantial value to the bark of this Amazonian species.
Identification of the Mechanism of Water Inrush from Coal Floor Based on Geological Conditions and Numerical modeling Technology
Authors: Qi Yueming , Zhou Pei , Pei Yifeng , Wu Jiaxin , Jiang Dan , Li Hongyu 
Published: March 2023

Abstract

In North China, Water inrush from the Ordovician limestone aquifer often occurs when deep coal seams are being mined due to the complicated geologic conditions and the limitations of existing detection methods. In order to deeply explore the water inrush mechanism, prevention methods, and the safe production guidance, taking the water inrush accident in the floor of the 2-112 mining face of the Ganhe coal mine in Shanxi as an example, the authors established a stress distribution model for the coal floor and used simulation method to study the water inrush process in the floor of 2-112 deep mining face. The results showed that under the condition of no geological defects in the coal seam floor, water inrush from the floor will not occur, which suggests there must be geologic defects in the floor, if water inrush occurs. According to the actual conditions and the response phenomenon of water inrush, through repeated simulation and identification, the results indicate that there is a concealed fault defect in the floor of the working face, the depth of which is about 10m under the coal floor, and the extension length is about 86m, and the inclination angle is about 70 degree. Under the coupling effect of ground stress, hydraulic pressure and mining action, the concealed fault is activated, and the plastic zone of the floor plate is enlarged, then a connected flow channel is formed. Consequently, the water inrush occurs driven by high hydraulic pressure.
Thermal Pedestrian Detection Based on Different Resolution Visual Image
Authors: Li Songtao , Cui Jinzhong , Ye Mao , Li Ting , Tian Liang 
Published: March 2023

Abstract
Thermal pedestrian detection is a core problem in computer vision. Usually, the corresponding visual image knowledge are used to improve the performance in thermal domain. However, existing methods always assume the same resolution between visible and thermal images. But in reality, there is a problem with this setting. Since thermal imaging acquisition equipment is expensive, the resolution of thermal images is always lower than visible images. To address this issue, we propose a new method, named as Disentanglement Then Restoration (DTR). The key idea is to disentangle the features into content features and modal features, andrestore the complete content features of thermal images by learning the changes of content features caused by different resolutions.Specifically, we first train an object detector such as YOLO to initialize our model. Then, a feature disentanglement network is trained, which can disentangle the features from the backbone as content features and modal features. In the end, the feature disentanglement network is frozen. By forcing the content feature consistency between visual image and upsampled thermal image, the complete content features of low-resolution thermal images are restored. Experiment results on public datasets show that our method performs very well.
RNA m6A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression
Authors: Cao Xuetao , Liu Yang , Song Renjie , Lu Zhike , Zhao Lu , Zhan Xinyi , Li Yini 
Published: March 2023

Abstract
Emergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor (G-CSF) through its receptor G-CSFR are essential for antibacterial innate defense. Yet the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and neutrophil innate response against bacterial infection remain largely unclear. N6-methyladenosine (m6A) RNA modification and its demethylase alkB homolog 5 (ALKBH5) are key epigenetic regulators of immunity and inflammation, whereas their roles in neutrophil generation and mobilization are still unknown. Using cecal ligation and puncture (CLP)-induced polymicrobial sepsis to model systemic bacterial infection, here we report that ALKBH5 is required for emergency granulopoiesis and neutrophil mobilization. ALKBH5 depletion significantly impaired the generation of immature neutrophils in bone marrow of sepsis mice. Meanwhile, Alkbh5-deficient mice exhibited higher retention of mature neutrophils in bone marrow and defective neutrophil release into blood, leading to less neutrophils in the infected site than wild-type littermates undergoing sepsis. Mechanistically, ALKBH5 imprinted generation- and mobilization-promoting transcriptome signatures in both mouse and human neutrophils during bacterial infection, especially upregulated G-CSFR expression by erasing m6A methylation on CSF3R mRNAs to inhibit their decay, consequently increasing the cell-surface G-CSFR expression and JAK-STAT signaling. RIP-qPCR confirmed a direct binding of ALKBH5 to CSF3R mRNAs and the binding strength was declined upon bacterial infection, accounting for the decreased G-CSFR on bacteria-infected neutrophils. Together, we define a new role of ALKBH5 in intrinsically driving neutrophil generation and mobilization through m6A demethylation-dependent post-transcriptional regulation, indicating neutrophil m6A RNA modification as the potential target for treating bacterial infections and neutropenia.
Orogenic lode-gold deposits and listvenization processes in the El-Barramiya area, Eastern Desert, Egypt
Authors: Abdelrady Mohamed , Elhadek Hany , Abdelmoneim Mohamed , Saleh Ahmed 
Published: March 2023

Abstract
Gold mineralization in the El-Barramiya region of the Eastern Desert, Egypt, is connected to the post-accretionary stage throughout the Central Eastern Desert. It is represented by quartz, quartz-carbonate veins and disseminations in listvenite rocks. The thrust contact between rock units in El-Barramiya area played an imperative part in gold mineralization where the obduction of ophiolitic rocks over the metasediments and metavolcanics caused shear zones. Mineralization in the study area formed along shear zones and the gold mineralization prefers to precipitate along the transition zone between low-grade regional metamorphic area which is represented by metasediments and high grade which is represented by actinolite schist. Gold mineralization lode of El-Barramiya gold mine area is situated in E-W trending quartz and quartz-carbonate veins along a shear zone located in the intersections between faults trend in NE-SW (Najd fault), NW-SE and thrust faults trend in NEE-SWW in metavolcanic and metasedimentary host rocks. Porphyry granite in the mine area played an important role in hydrothermal alteration process where it represents the source of K, listvenite formed when fluids rich in CO2 and bearing-K permeate and alter the previously altered ultramafic rocks, usually serpentinites of the ophiolitic mélange rocks. Listvenitization process includes silicification and carbonatization metasomatic processes, tectonized serpentinites are altered to listvenite as the carbonatization becomes more intense close to dipping transpressive faults. Geochemical studies of listvenite and mineralized veins helped to determine the ultramafic genesis of listvenite and gold transformed as gold bisulfide. Petrographic investigation and geochemical studies show different types of alterations (carbonatization and silicification) and mineralization. Mineralizations are represented by gold and sulfides (pyrite, arsenopyrite and smaller quantities of chalcopyrite, sphalerite, galena, tetrahedrite and gersdorffite) found in auriferous quartz veins and disseminated in listvenite. The area exposed to brittle - ductile deformation in addition to different types of structures such as faults and fractures controlling on the formation of mineralization and act as hydrothermal channels ways for fluid flow. Fluid inclusions studies revealed that gold mineralization was formed from heterogeneous trapping of H2O–CO2 fluids at a temperature of 280–340°C and pressure within the range 1.5–1.9 kbar, which is consistent with the mesothermal conditions.
Radiomics biomarkers are associated with survival in patients with Oesophageal Adenocarcinoma
Authors: Aoude Lauren , Wong Bernadette , Bonazzi Vanessa , Brosda Sandra , Moradi Hamed , Lonie James , Patel Kalpana , Bradford Julia , Bloxham Conor , Koufariotis Lambros , Pearson John , Atkinson Victoria , Law Phillip , Lampe Guy , Smithers B. , Vegh Viktor , Waddell Nicola , Miles Kenneth , Barbour Andrew 
Published: March 2023

Abstract
Objective: Radiomics studies have shown promising results defining image surrogates that predict treatment response and survival in oesophageal squamous cell carcinoma. There are limited studies examining radiogenomics profiles in oesophageal adenocarcinoma (OAC) and this warrants further exploration.
Background: Although advances have been made in the treatment of OAC, the five-year overall survival remains poor. Hence, there is a need for biomarkers to improve therapeutic approaches.
Methods: Image analysis was performed on pre-treatment PET/CT scans from 80 OAC patients. In the discovery cohort (n=50), CT texture analysis was performed using a filtration-histogram method to evaluate the prognostic value of image features. Whole-genome sequencing, RNA sequencing (RNAseq) and immunohistochemistry characterised the molecular pathways associated with the CT markers. A validation cohort (n=30) was used to confirm radiomics biomarkers.
Results: Analysis showed 3 CT markers were significantly associated with both disease-specific and disease-free survival. Combining these markers provided further prognostic significance. Furthermore, we identified a correlation between CT markers and major pathological response rate. Both RNAseq and immunohistochemistry confirmed that lower CD8 T-cell expression in the tumour correlated with the poor survival group predicted using CT markers. RNAseq gene set enrichment analysis identified pathways associated with these radiomics biomarkers. Finally, radiomics analysis in a validation cohort confirmed CT marker (SD, standard deviation) as a biomarker of survival and identified additional image features associated with patient survival.
Conclusions: This study demonstrates that radiogenomics has the potential to identify OAC subgroups with prognostic significance and support clinical decision making.