bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide characterization and evolutionary analysis of the AP2/ERF gene family in lettuce (Lactuca sativa)
Authors: Park Sunchung , Shi Ainong , Meinhardt Lyndel W. , Mou Beiquan 
Published: August 2023

Abstract
The APETALA2/ETHYLENE RESPONSIVE FACTOR (AP2/ERF) gene family plays vital roles in plants, serving as a key regulator in responses to abiotic stresses. Despite its significance, a comprehensive understanding of this family in lettuce remains incomplete. In this study, we performed a genome-wide search for the AP2/ERF family in lettuce and identified a total of 224 members. The duplication patterns provided evidence that both tandem and segmental duplications contributed to the expansion of this family. Ka/Ks ratio analysis demonstrated that, following duplication events, the genes have been subjected to purifying selection pressure, leading to selective constraints on their protein sequence. This selective pressure provides a dosage benefit against stresses in plants. Additionally, a transcriptome analysis indicated that some duplicated genes gained novel functions, emphasizing the contribution of both dosage effect and functional divergence to the family functionalities. Furthermore, an orthologous relationship study showed that 60% of genes descended from a common ancestor of Rosid and Asterid lineages, 28% from the Asterid ancestor, and 12% evolved in the lettuce lineage, suggesting lineage-specific roles in adaptive evolution. These results provide valuable insights into the evolutionary mechanisms of the AP2/ERF gene family in lettuce, with implications for enhancing abiotic stress tolerance, ultimately contributing to the genetic improvement of lettuce crop production.
Catalytic oxidation processes for the degradation of Progesterone using V2O5 catalyst and C/Ti anode: Optimization and degradation dynamics
Authors: Farissi Salman , Gopi Utukuri , Ajith Gara , Palasseri Harikrishnan , Prasanthi Tejomurtula , Muthukumar Anbazhagi , Muthuchamy Muthukumar 
Published: August 2023

Abstract
Progesterone (PGT) is a steroid hormone produced naturally by humans. Advent of pharmaceuticals has given rise to synthetic production of PGT as a medicine for various pregnancy related issues. As a result of synthetic production and utilization rate of PGT, they have become an emerging contaminant in water sources worldwide. Conventional wastewater treatment is not equipped to remove steroid contaminants. Hence, current study attempted the degradation of10 mgL− 1 of PGT in water using photocatalysis (PC) followed by electrocatalytic oxidation (EC) using Vanadium Pentoxide (V2O5) and carbon coated titanium (C/Ti) anode. Characterization involved XRD and FTIR spectral studies that established the stability of the catalyst with the fact that no adsorptive removal of PGT had taken place. Optimization studies found UV-C irradiation, pH 5, 50 mg L− 1 catalyst, 180 min PC, 210 min EC and 69 mA.cm− 2 managed to accomplish 97% COD and 71.5% TOC removal. Comparative studies showed that PC + EC (UV-C) was 50% and 25% more efficient than EO and EC, respectively, for TOC removal. PC pretreatment to EC was found capable of bringing down the current consumption requirement of electrolysis by 23 mA.cm− 2. High resolution mass spectrometry (HRMS) studies were utilized to propose the degradation pathway that involved hydroxylation, demethylation, dehydroxylation and decarboxylation mechanisms.
The relationship between extreme inter-individual variation in macrophage gene expression and genetic susceptibility to inflammatory bowel disease
Authors: O'Brien Claire , Summers Kim , Martin Natalia , Carter-Cusack Dylan , Yang Yuanhao , Barua Rasel , Dixit Ojas , Hume David , Pavli Paul 
Published: August 2023

Abstract
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor receptor (CSF1R). Analysis of genome-wide association studies (GWAS) indicates that dysregulation of macrophage differentiation and response to microorganisms contributes to susceptibility to chronic inflammatory bowel disease (IBD). Here, we analyzed transcriptomic variation in monocyte-derived macrophages (MDM) from affected and unaffected sib pairs/trios from 22 IBD families and 6 healthy controls. Transcriptional network analysis of the data revealed no overall or inter-sib distinction between affected and unaffected individuals in basal gene expression or the temporal response to lipopolysaccharide (LPS). However, the basal or LPS-inducible expression of individual genes varied independently by as much as 100-fold between subjects. Extreme independent variation in the expression of pairs of HLA-associated transcripts (HLA-B/C, HLA-A/F and HLA-DRB1/DRB5) in macrophages was associated with HLA genotype. Correlation analysis indicated the downstream impacts of variation in the immediate early response to LPS. For example, variation in expression of IL1B was significantly associated with local SNV genotype and with subsequent peak expression of target genes including IL23A, CXCL1, CXCL3, CXCL8 and NLRP3. Similarly, variation in IFNB1 expression was correlated with later expression of IFN target genes. Our results support the view that gene-specific dysregulation in macrophage adaptation to the intestinal milieu is associated with genetic susceptibility to IBD.
LMFD:Lightweight Multi-Feature Descriptors for Image Stitching
Authors: Yingbo Fan , Mao Shanjun , Li Mei , Kang Jitong , Ben Li 
Published: August 2023

Abstract
Image stitching is a fundamental pillar of computer vision, and its effectiveness hinges significantly on the quality of feature descriptors. However, the existing feature descriptors confront several challenges, including inadequate robustness to noise or rotational transformations and limited adaptability during hardware deployment. To address these limitations, this paper proposed a feature descriptor for image stitching, denoted as Lightweight Multi-Feature Descriptors (LMFD). By extensively extracting gradients, means, and global information surrounding the feature points, the feature descriptors are generated through various combinations to enhance the image stitching. This empowers the algorithm with formidable rotational invariance and noise resistance, thereby improving its accuracy and reliability. Furthermore, the feature descriptors take the form of binary matrices consisting of 0 and 1, which not only facilitates more efficient hardware deployment but also enhances computational efficiency. The utilization of binary matrices significantly reduces the computational complexity of the algorithm while preserving its efficacy. To validate the effectiveness of the LMFD, rigorous experimentation was conducted on the Hpatches and 2D-HeLa datasets. The results demonstrated that the LMFD outperformed state-of-the-art image matching algorithms in terms of accuracy. This empirical evidence solidifies the superiority of the LMFD and substantiates its potential for practical applications in various domains.
Lateral asymmetry of emotional arousal as a biomarker of attributional style during darts competitions
Authors: Szekely Szabolcs , Szekely Anna , Veres András , Kotyuk Eszter 
Published: August 2023

Abstract

According to the Multiple Arousal Theory, electrodermal activity (EDA) is not uniform across the body. However, the psychological meaning of a left or right sided EDA dominance is not clear. We explored EDA lateral asymmetry as a psychophysiological marker of optimistic and pessimistic attributional style regarding success and failure in a darts competition.
Bilateral EDA pattern of 230 throw actions of a competing pair was measured by Obimon EDA including accelerometer measurements of movements. First, we confirmed that lateral asymmetry can be measured reliably based on EDA data from both wrists. Second, we assessed attributional styles related to lateral asymmetry based on 80 individual throw actions. We recorded participants’ expectations regarding their upcoming throw performance, and their attribution of success and failure. Seligman’s definition was used to classify throw attributions as optimist (internal cause attributed to success, or external cause ascribed to failure) or pessimist. The ratio of optimist and pessimist attributions was significantly different for throw actions with right or left sided EDA dominance (p=0.001). Optimistic attribution characterized 84% of right-sided EDA throws, and pessimist attribution was present in 63% of left-sided EDA throws. We replicated these findings based on 50 throw actions from 10 more individuals (p=0.034).
We conclude that wrist EDA can be reliably measured during physical movements, such as throw actions in a darts game. Lateral EDA asymmetry is a consistent psychophysiological marker of the attitude towards success and failure in a competitive setting. Results underly the psychophysiological relevance of bilateral arousal assessment.
Virgin and Aged Microplastics Induce Type-specific Inflammatory Responses on Vascular Cells
Authors: Lomonaco Tommaso , Persiani Elisa , Biagini Denise , Gisone Ilaria , Ceccherini Elisa , Cecchettini Antonella , Corti Andrea , Ghimenti Silvia , Francesco Fabio Di , Castelvetro Valter , Vozzi Federico 
Published: August 2023

Abstract
Microplastics (MPs) are recognized as a major environmental problem due to their ubiquitous presence in ecosystems and bioaccumulation in food chains. Not only humans are continuously exposed to these pollutants through ingestion and inhalation, but recent findings suggest they may trigger vascular inflammation and potentially worsen the clinical conditions of cardiovascular patients. Here we combine headspace analysis by needle trap microextraction-gas chromatography-mass spectrometry and biological assays to evaluate the effects of polystyrene, high- and low-density polyethylene MPs on phenotype, metabolic activity, and pro-inflammatory status of Human Coronary Artery Smooth Muscle Cells (HCASMCs). Virgin and artificially aged MPs (4 weeks at 40 °C and 750 W/m2 simulated solar irradiation) were comparatively tested at 1 mg/mL to simulate a realistic exposure scenario. Our results clearly show the activation of oxidative stress and inflammatory processes when HCASMCs were cultured with aged polymers, with significant overexpression of IL-6 and TNF-α. In addition, volatile organic compounds (VOCs), including pentane, acrolein, propanal, and hexanal as the main components, were released into the headspace. Type-specific VOC response profiles were induced on vascular cells from different MPs.
Balance Impairment in Patients with Rheumatoid Arthritis and
Ankylosing Spondylitis
Authors: Kent Ali Erman , Gürses Emre , Karabekiroğlu Figen , Genç Aydan 
Published: August 2023

Background:
Balance weaknesses related to mobility and fall risk in patients with rheumatic
diseases are well-known. Vestibular dysfunction could negatively contribute to the balance
ability of this patient population. This study aims to investigate the effects of Rheumatoid Arthritis
(RA) and Ankylosing Spondylitis (AS), among the most common rheumatic diseases, on postural
balance related to vestibular function

Methods:
Seventy-eight participants were grouped as RA (n=34, 43%), AS (n=24, 30.7%), and the
control group consisted of healthy individuals (n=20, 25.6%). Cervical Vestibular Evoked Myogenic
Potentials (cVEMP) test, which assesses the vestibular function objectively, Dizziness Handicap
Inventory (DHI), which evaluates vertigo subjectively, and Berg Balance Scale (BBS) were
performed..

Results:
Different degrees of VEMP latency prolongations were found in the AS and RA groups.
Right, and left ear N1 latencies were significantly longer in the AS group than in RA and control.
Right ear P1 latency prolongation was statistically significant in the RA group. Amplitude asymmetry
ratio (AAR) was found to be considerably higher in the RA and AS groups than in the control
group (p < 0.05). The mean BBS score in the AS group was below the fall risk score of 45. A negative
statistically significant effect was observed between latency prolongation and BBS in AS
groups.

Conclusion:
The abnormal VEMP findings in individuals with RA and AS shows inner ear vestibular
system dysfunction. This vestibular impairment strictly contributes to their postural imbalance
and requires a focused vestibular rehabilitation program for balance treatment.
Anticancer Activity of Novel 1,3,4-oxadiazole Derivatives against PARP-1
Inhibitors: An In-silico Approach
Authors: Patel Praveen Kumar , Negi Preeya , Arun Sowmiya , Lakshmanan Kaviarasan , Byran Gowramma , Rajagopal Kalirajan , Swaminathan Gomathi 
Published: August 2023

Background:
Nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1) controls the
cell cycle, DNA repair, transcription, and replication processes. In this study, olaparib and
rucaparib have been taken as standard drugs for comparison of results. As per previous research
data, 1,3,4-Oxadiazole moiety has multidirectional biological activity and shows high activity
against cancer.

Objective:
This study aimed to carry out the in silico ligand-based screening for the identification
of hits for PARP1 inhibitors bearing 1,3,4-thiadiazole derivatives using Schrodinger suite 2022-1
and to perform MMGBSA and molecular dynamics simulation for lead molecules.

Methods:
A total of 32 derivatives of 1,3,4-Oxadiazole were designed with four different acids:
phenoxy acetic acid, 1-Naphthoxy acetic acid, 2-Naphthoxy acetic acid, and piperonylic acid. Molecular
docking (XP) studies were performed between 4ZZZ.pdb and the designed analogues, and
the binding affinity values lay in the range of -8.52 to -3.52 kcal/mol. 2D interactions between the
protein and the ligand were observed. Based on the binding affinity values and ADMET results, top
10 analogues were selected for performing MM-GBSA.

Results:
The dG-bind score of the top compounds varied from -2.30 to -60.67 kcal/mol, and analogue
D4 was selected for MD simulation studies for 100ns. Results of Molecular dynamics (MD)
studies showed that D4 interacted with amino acid residues, and the ligand-protein interaction stabilized
from 58-90ns. The in silico study's findings suggested that the chemicals A1, A3, B1, B2, B3,
B4, C1, C6, D1, and D4 might be significantly active against breast cancer with potential therapeutic
benefits and are likely to be useful after further development.

Conclusion:
In conclusion, numerous molecules exhibit a high affinity for PARP-1 when derived
from 1,3,4-oxadiazole. The in silico study's findings suggested that the chemicals A1, A3, B1, B2,
B3, B4, C1, C6, D1, and D4 might be significantly active against breast cancer with potential therapeutic
benefits and are likely to be useful after further development.
Overview of Path Planning Algorithms
Authors: Liu Hongbo , Zhang Shuai , Yang Xiaodong 
Published: August 2023

Background:
Path-planning algorithms are widely used in robotics, vehicles, UAVs, carrier-based aircraft towing vehicles, etc. Using these algorithms, an optimal path with safe obstacle avoidance and high efficiency can be planned. In recent years, path-planning algorithms have received more and more attention from scholars at home and abroad.

Objective:
In order to promote the application and development of path-planning algorithms, an in-depth analysis of the current development status of path-planning algorithms was presented. The most widely used and representative algorithms in several representative results were extracted, and the characteristics and advantages and disadvantages of each algorithm were analyzed and elaborated in detail for the readers' reference.

Methods:
The existing path-planning algorithms were classified, and a brief overview of each traditional algorithm was given, followed by an in-depth study of the improved algorithms to summarize the advantages and disadvantages of each type of algorithm. Finally, based on these research results, the future development trend of path-planning algorithms was projected.

Results:
Through the research and analysis of the path-planning algorithm, it was found that the path- planning algorithm before the improvement had the problems of an unsmooth path, low computational efficiency, a slow response time, the inability to safely avoid obstacles, etc. After the improvement and optimization of the path-planning algorithm, the performance was greatly improved.

Conclusion:
After research and analysis, it was found that multi-algorithm fusion had great potential for development in path-planning compared to the application and optimization of a single algorithm. In addition, further research is needed in the areas of algorithm adaptability, fusion, intelligent algorithms, and extending the range of algorithmic applications.
A Novel Spectrophotometric Method Development for Quantification of
Desidustat in Bulk and Pharmaceutical Dosage Form
Authors: Sharma Sanjay , Jain Sunidhi 
Published: August 2023

Background:
Desidustat (DES) belongs to a new category of drugs, i.e., Hypoxia-Inducible Factor (HIF) propyl hydroxylase inhibitor, and is used for the treatment of anemia in chronic kidney disease. However, no method has yet been reported in the literature for the estimation of drugs.

Objective:
The objective of the study is to develop a simple, precise, and accurate method for determining DES in bulk and pharmaceutical dose form.

Methods:
The stability-indicating HPLC method for assay included the use of Kromasil 100-5-C8 (100 mm × 4.6 mm) column, UV detector 224 nm, mobile phase composition involving a mixture of acetonitrile:water (52:48), and a flow rate of 1.0 mL/min. ICH guidelines were followed for the method's validation. To assess the method's specificity and stability in showing characteristics, stress degradation studies were carried out. The working standard solution of dapagliflozin was exposed to 1 and 2 N HCl by refluxing 1 and 2 N NaOH with 30% hydrogen peroxide by volume and UV radiation in order to conduct a degradation study.

Results:
Maximum absorbance wavelength was observed at 229 nm. The sample solution remained stable for up to 12 hours. The linear response from 2 to 12 μg/ml of DES was y = 0.1087x + 0.0962 and r2 = 0.9963. The accuracy was between 100 to 101%. Precision was recorded under three criteria: repeatability, intraday and interday, for which results fell within the acceptable ranges (<2%). The limit of detection (LOD) and limit of quantification (LOQ) of the technique were 0.434 μg/ml and 1.316 μg/ml, respectively.

Conclusion:
The proposed method was found to be beneficial for drug monitoring and the ongoing analysis of DES in research and quality control laboratories. This approach is simple, precise, rapid, economical, and sensitive
Evaluating the Effectiveness of Apps Designed to Reduce Mobile Phone Use and Prevent Maladaptive Mobile Phone Use: Multimethod Study
Authors: Rahmillah Fety Ilma , Tariq Amina , King Mark , Oviedo-Trespalacios Oscar 
Published: August 2023

Background
Mobile apps are a popular strategy for reducing mobile phone use and preventing maladaptive mobile phone use (MMPU). Previous research efforts have been made to understand the features of apps that have the potential to reduce mobile phone use and MMPU. However, there has been a lack of a comprehensive examination of the effectiveness of such apps and their features.

Objective
This paper investigated existing apps designed to reduce mobile phone use and prevent MMPU and examined the evidence of their effectiveness. The research aimed to provide a comprehensive analysis of app features that can reduce mobile phone use and MMPU, while also assessing their effectiveness. In addition, we explored users’ perceptions of these apps and the various features the apps offer to understand potential adoption issues and identify opportunities.

Methods
This study used 3 methods: a review of scientific evidence, content analysis, and sentiment analysis.

Results
Our study comprehensively examine the common features of 13 apps designed to reduce mobile phone use. We extracted and classified the features into 7 types: self-tracking, social tracking, goal setting, blocking, gamification, simplification, and assessment. The effectiveness of these apps in reducing mobile phone use and MMPU varied from weak to strong. On the basis of content analysis, self-tracking and goal setting were the most frequently used features, whereas gamification and assessment were used the least frequently. The intervention strategies that effectively reduce mobile phone use and MMPU included using grayscale mode, app limit features, and mixed interventions. Overall, users tended to accept these apps, as indicated by sentiment scores ranging from 61 to 86 out of 100.

Conclusions
This study demonstrates that app-based management has the potential to reduce mobile phone use and MMPU. However, further research is required to evaluate the effectiveness of app-based interventions. Collaborations among researchers, app developers, mobile phone manufacturers, and policy makers could enhance the process of delivering, evaluating, and optimizing apps aimed at reducing mobile phone use and MMPU.
Adapting the Diabetes Prevention Program for Older Adults: Descriptive Study
Authors: Beasley Jeannette M , Johnston Emily A , Costea Denisa , Sevick Mary Ann , Rogers Erin S , Jay Melanie , Zhong Judy , Chodosh Joshua 
Published: August 2023

Background
Prediabetes affects 26.4 million people aged 65 years or older (48.8%) in the United States. Although older adults respond well to the evidence-based Diabetes Prevention Program, they are a heterogeneous group with differing physiological, biomedical, and psychosocial needs who can benefit from additional support to accommodate age-related changes in sensory and motor function.

Objective
The purpose of this paper is to describe adaptations of the Centers for Disease Control and Prevention’s Diabetes Prevention Program aimed at preventing diabetes among older adults (ages ≥65 years) and findings from a pilot of 2 virtual sessions of the adapted program that evaluated the acceptability of the content.

Methods
The research team adapted the program by incorporating additional resources necessary for older adults. A certified lifestyle coach delivered 2 sessions of the adapted content via videoconference to 189 older adults.

Results
The first session had a 34.9% (38/109) response rate to the survey, and the second had a 34% (30/88) response rate. Over three-quarters (50/59, 85%) of respondents agreed that they liked the virtual program, with 82% (45/55) agreeing that they would recommend it to a family member or a friend.

Conclusions
This data will be used to inform intervention delivery in a randomized controlled trial comparing in-person versus virtual delivery of the adapted program.