bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is he or she the main player in table tennis mixed doubles?
Authors: Zhou Zheng , Zhang Hui 
Published: January 2023

Abstract
Background
Since mixed doubles have been set up in the table tennis competition of the 2020 Tokyo Olympic Games, coaches and players have paid increasing attention to mixed doubles matches. This study aims to compare and analyse male and female performance in the different contexts of table tennis mixed doubles as well as the impact of their performance on the probability of winning matches.

Methods
100 matches between the top 30 mixed doubles were selected (based on the world rankings for 2019 to 2021) as samples. According to the stroke order of a mixed doubles match, the players are divided into four groups: male versus male (Pm–m), male versus female (Pm–f), female versus male (Pf–m) and female versus female (Pf–f). Then, new methods with concepts are proposed to analyse stroke performance by four groups of players in various competition contexts of mixed doubles.

Results
(1) The stroke performance in the first four strokes was much better than that in the after four strokes (P < 0.05), and males performed better than female players in the first four strokes (P < 0.05). (2) The stroke performance of each group for winning matches was significantly better than that for losing matches (P < 0.01). (3) Players in each group performed better (P < 0.01) in the ahead and under control states than in the behind and lost control states. However, most stroke performance within the four groups was not significantly different in different states. (4) The impact of scoring rates by different groups on the winning probability of a mixed doubles match from high to low was Pm–f > Pf–f > Pm–m > Pf–m. (5) In the actual competition, the percentage of female players serving first in each game is 79.64%, and the percentage of the stroke group of female players serving to female players receiving (Pf–f) is 58.25%.

Conclusion
This study considers several competition contexts to analyse the performance of male and female players in table tennis mixed doubles. We propose that the stroke performance of male versus female players is the most important factor affecting the results of mixed doubles matches. In addition, selecting the first server or first receiver in each game reasonably and analysing the stroke orders emphatically are also very important in mixed doubles.
Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy
Authors: Sandouka Sereen , Saadi Aseel , Singh Prince Kumar , Olowe Rhoda , Shekh-Ahmad Tawfeeq 
Published: January 2023

Abstract
Background
Drug resistance is a particular problem in patients with temporal lobe epilepsy, where seizures originate mainly from the hippocampus. Many of these epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure. Such conditions are characterized by pathophysiological mechanisms including massive oxidative stress that synergistically mediate the secondary brain damage, contributing to the development of epilepsy. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) has emerged in recent years as an attractive therapeutic approach targeting to upregulate the antioxidative defenses in the cell, to ameliorate the oxidative stress-induced damage. Thus, it is important to understand the characteristics of Nrf2 activation during epileptogenesis and epilepsy. Here, we studied the temporal, regional, and cell-type specific expression of Nrf2 in the brain, in a rat model of temporal lobe epilepsy.

Results
Early after status-epilepticus, Nrf2 is mainly activated in the hippocampus and maintained during the whole period of epileptogenesis. Only transient expression of Nrf2 was observed in the cortex. Nevertheless, the expression of several Nrf2 antioxidant target genes was increased within 24 h after status-epilepticus in both the cortex and the hippocampus. We demonstrated that after status-epilepticus in rats, Nrf2 is predominantly expressed in neurons in the CA1 and CA3 regions of the hippocampus, and only astrocytes in the CA1 increase their Nrf2 expression.

Conclusions
In conclusion, our data identify previously unrecognized spatial and cell-type dependent activation of Nrf2 during epilepsy development, highlighting the need for a time-controlled, and cell-type specific activation of the Nrf2 pathway for mediating anti-oxidant response after brain insult, to modify the development of epilepsy.
WOX11: the founder of plant organ regeneration
Authors: Wan Qihui , Zhai Ning , Xie Dixiang , Liu Wu , Xu Lin 
Published: January 2023

AbstractDe novo organ regeneration is the process in which adventitious roots or shoots regenerate from detached or wounded organs. De novo organ regeneration can occur either in natural conditions, e.g. adventitious root regeneration from the wounded sites of detached leaves or stems, or in in-vitro tissue culture, e.g. organ regeneration from callus. In this review, we summarize recent advances in research on the molecular mechanism of de novo organ regeneration, focusing on the role of the WUSCHEL-RELATED HOMEOBOX11 (WOX11) gene in the model plant Arabidopsis thaliana. WOX11 is a direct target of the auxin signaling pathway, and it is expressed in, and regulates the establishment of, the founder cell during de novo root regeneration and callus formation. WOX11 activates the expression of its target genes to initiate root and callus primordia. Therefore, WOX11 links upstream auxin signaling to downstream cell fate transition during regeneration. We also discuss the role of WOX11 in diverse species and its evolution in plants.
Response to back-to-back outbreaks of circulating vaccine-derived poliovirus type 2 in two nomadic pastoralist settlements in Oti Region, Ghana-2019
Authors: Ameme Donne Kofi , Yeboah Yaw Ofori , Odoom John Kofi , Djokoto Senanu Kwesi , Akyereko Ernest , Mamudu Abdulaziz , Diwura Mukaila , Opare William , Avevor Patrick , Diamenu Stanley , Ohene Sally-Ann , Kenu Ernest , Asiedu-Bekoe Franklin 
Published: January 2023

Abstract
Background
The global switch from trivalent oral poliovirus vaccine (OPV) to bivalent OPV in April 2016 without corresponding co-administration of inactivated poliovirus vaccine (IPV) until June 2018, created a cohort of poliovirus type 2 naïve children with risk of developing vaccine-derived poliovirus type 2 (VDPV2). In November and December 2019, two cases of circulating vaccine-derived poliovirus type 2 (cVDPV2) were confirmed in quick succession through Acute Flaccid Paralysis (AFP) surveillance in two nomadic pastoralist settlements in Oti Region. We investigated to determine the outbreak extent, identify risk factors and implement control and preventive measures.

Methods
We interviewed case-patients’ families, abstracted immunization records, assessed AFP surveillance and conducted rapid OPV and IPV vaccination coverage surveys. Using AFP case definition of any child less than 15 years in the community with sudden onset of paralysis from July to November 2019 (in case-patient 1’s district) and August to December 2019 (in case-patient 2’s district), we conducted active case search. Stool samples from apparently healthy children and close contacts of the case-patients were collected and tested for poliovirus. We conducted environmental assessment of the community to identify potential risk factors.

Results
Case-patient 1 was an eight-year-old female who had taken two doses of OPV while case-patient 2 was an eight-month-old male who had taken three out of required four OPV doses in addition to IPV at seven months. Families of both case-patients had either travelled to or received visitors from areas with confirmed cVDPV2. Of all children surveyed, eight (29.6%) of 27 and three (18.8%) of 16 eligible children in communities of case-patient 1 and 2 respectively had received required four doses of OPV. No AFP case was found in both communities and surrounding settlements. Both communities had no source of potable water and toilet facilities. A stool sample from a contact of case-patient 1 tested positive for cVDPV2.

Conclusion
Outbreaks of cVDPV2 occurred in insanitary, under-vaccinated nomadic pastoralist settlements in Oti Region. Three rounds of monovalent OPV vaccination campaigns for children under 5 years of age in the districts and region as well as countrywide IPV vaccination campaign for poliovirus type 2 naïve cohort were conducted.
Survival outcome among patients with out-of-hospital cardiac arrest who received cardiopulmonary resuscitation in China: a systematic review and meta-analysis
Authors: Zhou Guozhong , Wang Yan , Sun Zihong , Yuan Mingqi , Ma Yunlin , Wu Qianxi , Wu Chunyan , Xu Jing , Li Yongyi , Liu Yunchuan , Wang Zhenzhou , Song Chao 
Published: January 2023

Abstract
Background
This study aimed to assess the survival outcomes among patients with out-of-hospital cardiac arrest (CA) who received cardiopulmonary resuscitation (CPR) in China.

Methods
Relevant studies, published between January 1, 2010 and September 5, 2022, were retrieved from databases, including EMBASE, PubMed, Cochrane Library, the China Biology Medicine disk, China National Knowledge Infrastructure, and Wanfang databases. We included clinical studies in which all patients were diagnosed with CA and underwent out-of-hospital CPR, and the outcome variables were at least one of the following: return of spontaneous circulation (ROSC), survival to admission, survival to hospital discharge, 1-month survival, achieved good neurological outcomes, and 1-year survival. Two investigators independently extracted the study data and assessed its quality using a modified Newcastle–Ottawa Scale tool. The data were pooled using random-effects models.

Results
Of the 3620 identified studies, 49 (63,378 patients) were included in the meta-analysis. The pooled ROSC rate was 9.0% (95% confidence interval [CI] 7.5–10.5%, I2 = 97%), the pooled survival to admission rate was 5.0% (95% CI 2.7–8.0%, I2 = 98%), and the pooled survival to discharge rate was 1.8% (95% CI 1.2–2.5%, I2 = 95%). Additionally, the ROSC rate of patients with bystander CPR was significantly higher than that of those without bystander CPR, and the pooled odds ratio (OR) was 7.92 (95% CI 4.32–14.53, I2 = 85%). The ROSC rate of participants who started CPR within 5 min was significantly higher than that of those who started CPR after 5 min, and the pooled OR was 5.92 (95% CI 1.92–18.26, I2 = 85%). The ROSC rate of participants with defibrillation was significantly higher than that of those without defibrillation, and the pooled OR was 8.52 (95% CI 3.72–19.52, I2 = 77%).

Conclusion
The survival outcomes of out-of-hospital CPR in China are far below the world average. Therefore, the policy of providing automated external defibrillators (AEDs) in public places and strengthening CPR training for healthcare providers and public personnel should be encouraged and disseminated nationwide.
Trial registration This study was registered in PROSPERO (CRD42022326165) on 29 April 2022.
Distributing transmitters to maximize population-level representativeness in automated radio telemetry studies of animal movement
Authors: Lamb Juliet S. , Loring Pamela H. , Paton Peter W. C. 
Published: January 2023

AbstractTelemetry is a powerful and indispensable tool for evaluating wildlife movement and distribution patterns, particularly in systems where opportunities for direct observation are limited. However, the effort and expense required to track individuals often results in small sample sizes, which can lead to biased results if the sample of tracked individuals does not fully capture spatial, temporal, and individual variability within the target population. To better understand the influence of sampling design on results of automated radio telemetry studies, we conducted a retrospective power analysis of very high frequency (VHF) radio telemetry data from the Motus Wildlife Tracking System for two species of birds along the United States Atlantic coast: a shorebird, the piping plover (Charadrius melodus), and a nearshore seabird, the common tern (Sterna hirundo). We found that ~ 100–150 tracked individuals were required to identify 90% of locations known to be used by the tracked population, with 40–50 additional individuals required to include 95% of used locations. For any number of individuals, the percentage of stations included in the sample was higher for common terns than for piping plovers when tags were deployed within a single site and year. Percentages of stations included increased for piping plovers when birds were tagged over multiple sites and, to a lesser extent, years, and increased with average length of the tracking period. The probability that any given receiver station used by the population would be included in a subsample increased with the number of birds tracked, station proximity to a migratory stopover or staging site, number of receiving antennas per station, and percentage of the tracked population present. Our results provide general guidance for the number and distribution of tagged birds required to obtain representative VHF telemetry data, while also highlighting the importance of accounting for station network configuration and species-specific differences in behavior when designing automated radio telemetry studies to address specific research questions. Our results have broad applications to remotely track movements of small-bodied migratory wildlife in inaccessible habitats, including predicting and monitoring effects of offshore wind energy development.
Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities
Authors: Solé-Guardia Gemma , Custers Emma , de Lange Arthur , Clijncke Elyne , Geenen Bram , Gutierrez Jose , Küsters Benno , Claassen Jurgen A. H. R. , de Leeuw Frank-Erik , Wiesmann Maximilian , Kiliaan Amanda J. 
Published: January 2023

AbstractThe major vascular cause of dementia is cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) amongst others. While the underlying pathology of SVD remains unclear, chronic hypertension and neuroinflammation are recognized as important risk factors for SVD and for the conversion of normal-appearing white matter (NAWM) to WMH. Unfortunately, most studies investigating the role of neuroinflammation in WMH relied on peripheral blood markers, e.g., markers for systemic or vascular inflammation, as a proxy for inflammation in the brain itself. However, it is unknown whether such markers accurately capture inflammatory changes within the cerebral white matter. Therefore, we aimed to comprehensively investigate the impact of hypertension on perivascular- and neuroinflammation in both WMH and NAWM. We conducted high field brain magnetic resonance imaging (MRI), followed by (immuno-)histopathological staining of neuroinflammatory markers on human post-mortem brains of elderly people with a history of hypertension (n = 17) and age-matched normotensive individuals (n = 5). MRI images were co-registered to (immuno-)histopathological data including stainings for microglia and astroglia to assess changes in MRI-based WMH at microscopic resolution. Perivascular inflammation was carefully assessed based on the severity of perivascular astrogliosis of the smallest vessels throughout white matter regions. Hypertension was associated with a larger inflammatory response in both WMH and NAWM. Notably, the presence of close-range perivascular inflammation was twice as common among those with hypertension than in controls both in WMH and NAWM, suggesting that neurovascular inflammation is critical in the etiology of WMH. Moreover, a higher degree of microglial activation was related to a higher burden of WMH. Our results indicate that neuro(vascular)inflammation at the level of the brain itself is involved in the etiology of WMH. Future therapeutic strategies focusing on multitarget interventions including antihypertensive treatment as well as neuroinflammation may ameliorate WMH progression.
Exploring the moderating role of financial development in environmental Kuznets curve for South Africa: fresh evidence from the novel dynamic ARDL simulations approach
Authors: Udeagha Maxwell Chukwudi , Breitenbach Marthinus Christoffel 
Published: January 2023

AbstractThe extant literature has produced mixed evidence on the relationship between financial development and ecological sustainability. This work addresses this conundrum by investigating financial development’s direct and indirect consequences on ecological quality utilizing the environmental Kuznets curve (EKC) methodological approach. Our empirical analysis is based on the novel dynamic autoregressive distributed lag simulations approach for South Africa between 1960 and 2020. The results, which used five distinct financial development measures, demonstrate that financial development boosts ecological integrity and environmental sustainability over the long and short terms. In the instance of South Africa, we additionally confirm the validity of the EKC theory. More importantly, the outcomes of the indirect channels demonstrate that financial development increases energy usage’s role in causing pollution while attenuating the detrimental impacts of economic growth, trade openness, and foreign direct investment on ecological quality. Moreover, the presence of an inadequate financial system is a requirement for the basis of the pollution haven hypothesis (PHH), which we examine using trade openness and foreign direct investment variables. PHH for both of these variables disappears when financial development crosses specified thresholds. Finally, industrial value addition destroys ecological quality while technological innovation enhances it. This research provides some crucial policy recommendations and fresh perspectives for South Africa as it develops national initiatives to support ecological sustainability and reach its net zero emissions goal.
Landscape-scale fuel treatment effectiveness: lessons learned from wildland fire case studies in forests of the western United States and Great Lakes region
Authors: Urza Alexandra K. , Hanberry Brice B. , Jain Theresa B. 
Published: January 2023

AbstractBackgroundMaximizing the effectiveness of fuel treatments at landscape scales is a key research and management need given the inability to treat all areas at risk from wildfire. We synthesized information from case studies that documented the influence of fuel treatments on wildfire events. We used a systematic review to identify relevant case studies and extracted information through a series of targeted questions to summarize experiential knowledge of landscape fuel treatment effectiveness. Within a larger literature search, we identified 18 case study reports that included (1) manager assessment of fuel treatment effectiveness during specific wildfire events; (2) fuel treatment effects on fire size, severity, and behavior outside of the treatment boundaries; and (3) the influence of fuel treatments on fire suppression tactics.ResultsSeventeen of the 18 case studies occurred in the western United States, and all were primarily focused on forested ecosystems. Surface fire behavior was more commonly observed in areas treated for fuel reduction than in untreated areas, which managers described as evidence of treatment effectiveness. Reduced fire intensity diminished fire effects and supported fire suppression efforts, while offering the potential to use wildfires as a fuel treatment surrogate.ConclusionsManagers considered treatments to be most effective at landscape scales when fuels were reduced in multiple fuel layers (crown, ladder, and surface fuels), across larger portions of the landscape. Treatment effectiveness was improved by strategic placement of treatments adjacent to prior treatments or past wildfires, in alignment with prevailing winds, and adjacent to natural fire breaks (e.g., ridgetops), efforts that effectively expanded the treatment area. Placement in relation to suppression needs to protect infrastructure also can take advantage of continuity with unvegetated land cover (e.g., parking lots, streets). Older treatments were considered less effective due to the regrowth of surface fuels. Treatment effectiveness was limited during periods of extreme fire weather, underscoring the need for treatment designs to incorporate the increasing occurrence of extreme burning conditions. Overall, fuel treatment effectiveness would be improved by the increased use of landscape-scale treatment designs that integrate fuels, topography, prevailing winds, fire or treatment history, and available infrastructure.
Genome-wide landscape of RNA-binding protein (RBP) networks as potential molecular regulators of psychiatric co-morbidities: a computational analysis
Authors: Nishanth M. J. , Jha Shanker 
Published: January 2023

AbstractBackgroundPsychiatric disorders are a major burden on global health. These illnesses manifest as co-morbid conditions, further complicating the treatment. There is a limited understanding of the molecular and regulatory basis of psychiatric co-morbidities. The existing research in this regard has largely focused on epigenetic modulators, non-coding RNAs, and transcription factors. RNA-binding proteins (RBPs) functioning as multi-protein complexes are now known to be predominant controllers of multiple gene regulatory processes. However, their involvement in gene expression dysregulation in psychiatric co-morbidities is yet to be understood.ResultsTen RBPs (QKI, ELAVL2, EIF2S1, SRSF3, IGF2BP2, EIF4B, SNRNP70, FMR1, DAZAP1, and MBNL1) were identified to be associated with psychiatric disorders such as schizophrenia, major depression, and bipolar disorders. Analysis of transcriptomic changes in response to individual depletion of these RBPs showed the potential influence of a large number of RBPs driving differential gene expression, suggesting functional cross-talk giving rise to multi-protein networks. Subsequent transcriptome analysis of post-mortem human brain samples from diseased and control individuals also suggested the involvement of ~ 100 RBPs influencing gene expression changes. These RBPs were found to regulate various processes including transcript splicing, mRNA transport, localization, stability, and translation. They were also found to form an extensive interactive network. Further, hnRNP, SRSF, and PCBP family RBPs, Matrin3, U2AF2, KHDRBS1, PTBP1, and also PABPN1 were found to be the hub proteins of the RBP network.ConclusionsExtensive RBP networks involving a few hub proteins could result in transcriptome-wide dysregulation of post-transcriptional modifications, potentially driving multiple psychiatric disorders. Understanding the functional involvement of RBP networks in psychiatric disorders would provide insights into the molecular basis of psychiatric co-morbidities.