bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transformation From NHx to NOy Deposition Aggravated China's Forest Soil Acidification
Authors: Zhang Qiongyu , Zhu Jianxing , Wang Qiufeng , Mulder Jan , Liu Congqiang , He Nianpeng 
Published: May 2023

AbstractElevated nitrogen (N) deposition and changes in reduced or oxidized component contribution greatly affect soil acidification. China has experienced a significant transformation of N deposition components from NHx to NOy over the past 40 years, but the effects of component transformation on soil acidification are poorly understood. Therefore, long‐term monitoring data and literature on N deposition, combined with the results of isotope experiments, were used to explore the contributions of different N forms on soil acidification in China's forests. Here, all processes related to NHx and NOy, including the transformation to NH4+ and NO3− and subsequent N cycling in the soil, were considered. We found that N‐induced soil acidification in 80% area of China’s forests was dominated by NHx deposition, and the other areas (South China) were dominated by NOy deposition in 2010s. From 1980 to 2019, the average contribution of NHx was higher than that of NOy but the latter contribution continued to increase. Meanwhile, the results showed that soil acidification increased with the decrease of the ratio of NHx to NOy (RNHx/NOy), which is mainly because NOy is more easily leached in the form of NO3− than that of NHx under the influence of different plant preferences and soil retention rates, resulting in a higher net proton production of NOy. Our research has powerful implications for policymaking, provides a theoretical basis for formulating different N reduction policies in different regions, and points out that the synergistic effect of RNHx/NOy changes should be considered to alleviate soil acidification.
Phase Shift of the Winter South China Sea Western Boundary Current Over the Past Two Decades and Its Drivers
Authors: Wang Qiang , Zeng Lili , Chen Ju , He Yunkai , Liu Qinyan , Sui Dandan , Wang Dongxiao 
Published: May 2023

AbstractThe winter South China Sea (SCS) western boundary current (WBC) has presented a significant weak–strong–weak phase shift in the last two decades, as revealed by observations and model products. Its phase shift has mainly been attributed to the joint effect of wind stress curl over the SCS and Luzon Strait transport (LST). Changes in the wind stress curl and planetary vorticity input through the Luzon Strait are the two major sources maintaining the winter SCS WBC state in different phases. The LST is closely related to the Kuroshio strength and thus the Pacific North Equatorial Current (NEC) bifurcation. Therefore, the winter SCS WBC phase shift is attributed to phase shifts of the winter monsoon and the NEC bifurcation, which are mostly related to those of the Indian Ocean Dipole Mode and Atlantic Multidecadal Oscillation, respectively. Understanding the SCS circulation low‐frequency variability is essential to forecast its thermodynamic state and regional climate effect.
The Rainfall Intensity‐Duration Control of Debris Flows After Wildfire
Authors: Thomas Matthew A. , Lindsay Donald N. , Cavagnaro David B. , Kean Jason W. , McCoy Scott W. , Graber Andrew P. 
Published: May 2023

AbstractIncreased wildfire activity in the western United States has exposed regional gaps in our understanding of postfire debris‐flow generation. To address this problem, we characterized flows in an unstudied area to test the rainfall intensity‐duration control of the hazard. Our rainfall measurements and field observations from the northern Sierra Nevada (California, USA) show that debris flows resulted from a short burst rainfall during a low‐accumulation storm. In contrast, a much higher accumulation storm (∼10 times more rainfall) with lower short‐duration rainfall rates only produced low‐hazard flooding. We conclude that total storm rainfall is not an ideal metric for identifying the rainfall conditions that initiate runoff‐generated debris flows in the first year after wildfire. Rather, a focus on short‐duration (<1 hr), high‐intensity rainfall that can occur during localized thunderstorms, or bands of intense rainfall during prolonged rainstorms, is more beneficial for the purposes of hazard assessment and warning.
Water Ages Explain Tradeoffs Between Long‐Term Evapotranspiration and Ecosystem Drought Resilience
Authors: Knighton J. , Berghuijs W. R. 
Published: May 2023

AbstractThe partitioning of terrestrial precipitation into evapotranspiration and river flow shapes ecosystems and water resources. Using observed precipitation, discharge, and satellite‐derived soil moisture and vegetation indices for watersheds located throughout the contiguous United States, we demonstrate that ecosystems maximize long‐term average evapotranspiration when plants transpire older water (i.e., longer time since precipitation or snowmelt). However, ecosystems that transpire older water do so at the expense of decreased drought resilience and maintain higher stem water resilience than those that use younger water, suggesting a growth versus drought resilience tradeoff that is well predicted by water age. These findings indicate that the role of water age integrates processes whereby the relevance of age extends beyond its previously studied effects on biochemical and transport processes, as we reveal it shapes long‐term terrestrial evaporation rates and ecosystem plant functioning under drought stress.
Unsupervised full-color cellular image reconstruction through disordered optical fiber
Authors: Hu Xiaowen , Zhao Jian , Antonio-Lopez Jose Enrique , Correa Rodrigo Amezcua , Schülzgen Axel 
Published: May 2023

AbstractRecent years have witnessed the tremendous development of fusing fiber-optic imaging with supervised deep learning to enable high-quality imaging of hard-to-reach areas. Nevertheless, the supervised deep learning method imposes strict constraints on fiber-optic imaging systems, where the input objects and the fiber outputs have to be collected in pairs. To unleash the full potential of fiber-optic imaging, unsupervised image reconstruction is in demand. Unfortunately, neither optical fiber bundles nor multimode fibers can achieve a point-to-point transmission of the object with a high sampling density, as is a prerequisite for unsupervised image reconstruction. The recently proposed disordered fibers offer a new solution based on the transverse Anderson localization. Here, we demonstrate unsupervised full-color imaging with a cellular resolution through a meter-long disordered fiber in both transmission and reflection modes. The unsupervised image reconstruction consists of two stages. In the first stage, we perform a pixel-wise standardization on the fiber outputs using the statistics of the objects. In the second stage, we recover the fine details of the reconstructions through a generative adversarial network. Unsupervised image reconstruction does not need paired images, enabling a much more flexible calibration under various conditions. Our new solution achieves full-color high-fidelity cell imaging within a working distance of at least 4 mm by only collecting the fiber outputs after an initial calibration. High imaging robustness is also demonstrated when the disordered fiber is bent with a central angle of 60°. Moreover, the cross-domain generality on unseen objects is shown to be enhanced with a diversified object set.
RNA alternative splicing impacts the risk for alcohol use disorder
Authors: Li Rudong , Reiter Jill L. , Chen Andy B. , Chen Steven X. , Foroud Tatiana , Edenberg Howard J. , Lai Dongbing , Liu Yunlong 
Published: May 2023

AbstractAlcohol use disorder (AUD) is a complex genetic disorder characterized by problems arising from excessive alcohol consumption. Identifying functional genetic variations that contribute to risk for AUD is a major goal. Alternative splicing of RNA mediates the flow of genetic information from DNA to gene expression and expands proteome diversity. We asked whether alternative splicing could be a risk factor for AUD. Herein, we used a Mendelian randomization (MR)-based approach to identify skipped exons (the predominant splicing event in brain) that contribute to AUD risk. Genotypes and RNA-seq data from the CommonMind Consortium were used as the training dataset to develop predictive models linking individual genotypes to exon skipping in the prefrontal cortex. We applied these models to data from the Collaborative Studies on Genetics of Alcoholism to examine the association between the imputed cis-regulated splicing outcome and the AUD-related traits. We identified 27 exon skipping events that were predicted to affect AUD risk; six of these were replicated in the Australian Twin-family Study of Alcohol Use Disorder. Their host genes are DRC1, ELOVL7, LINC00665, NSUN4, SRRM2 and TBC1D5. The genes downstream of these splicing events are enriched in neuroimmune pathways. The MR-inferred impacts of the ELOVL7 skipped exon on AUD risk was further supported in four additional large-scale genome-wide association studies. Additionally, this exon contributed to changes of gray matter volumes in multiple brain regions, including the visual cortex known to be involved in AUD. In conclusion, this study provides strong evidence that RNA alternative splicing impacts the susceptibility to AUD and adds new information on AUD-relevant genes and pathways. Our framework is also applicable to other types of splicing events and to other complex genetic disorders.
TMTC1 promotes invasiveness of ovarian cancer cells through integrins β1 and β4
Authors: Yeh Ting-Chih , Lin Neng-Yu , Chiu Chin-Yu , Hsu Tzu-Wen , Wu Hsin-Yi , Lin Hsuan-Yu , Chen Chi-Hau , Huang Min-Chuan 
Published: May 2023

AbstractOvarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Although O-mannosyltransferase TMTC1 is highly expressed by ovarian cancer, its pathophysiological role in ovarian cancer remains unclear. Here, immunohistochemistry showed that TMTC1 was overexpressed in ovarian cancer tissues compared with adjacent normal ovarian tissues, and high TMTC1 expression was associated with poor prognosis in patients with ovarian cancer. Silencing TMTC1 reduced ovarian cancer cell viability, migration, and invasion in vitro, as well as suppressed peritoneal tumor growth and metastasis in vivo. Moreover, TMTC1 knockdown reduced cell-laminin adhesion, which was associated with the decreased phosphorylation of FAK at pY397. Conversely, TMTC1 overexpression promoted these malignant properties in ovarian cancer cells. Glycoproteomic analysis and Concanavalin A (ConA) pull-down assays showed that integrins β1 and β4 were novel O-mannosylated protein substrates of TMTC1. Furthermore, TMTC1-mediated cell migration and invasion were significantly reversed by siRNA-mediated knockdown of integrin β1 or β4. Collectively, these results suggest that TMTC1-mediated invasive behaviors are primarily through integrins β1 and β4 and that TMTC1 is a potential therapeutic target for ovarian cancer.
A novel frameshift variant in UBA2 causing split-hand/foot malformations in a Pakistani family
Authors: Parveen Asia , Tariq Muhammad , Khan Sher Alam , Kakar Naseebullah , Arif Amina , Wasif Naveed 
Published: May 2023

AbstractSplit-hand/foot malformation (SHFM) shows diverse heterogeneity and manifests with reduced penetrance and variable expressivity. This study investigated the underlying genetic cause of a family segregating SHFM. Exome sequencing followed by Sanger sequencing identified a novel single nucleotide heterozygous variant (NC_000019.9 (NM_005499.3):c.1118del) in UBA2 cosegregating in the family in an autosomal dominant manner. Our findings conclude that reduced penetrance and variable expressivity are the two remarkable and unusual features of SHFM.
Identification of Probucol as a candidate for combination therapy with Metformin for Type 2 diabetes
Authors: Guttapadu Ranjitha , Korla Kalyani , UK Safnaz , Annam Vamseedhar , Ashok Purnima , Chandra Nagasuma 
Published: May 2023

AbstractType 2 Diabetes (T2D) is often managed with metformin as the drug of choice. While it is effective overall, many patients progress to exhibit complications. Strategic drug combinations to tackle this problem would be useful. We constructed a genome-wide protein-protein interaction network capturing a global perspective of perturbations in diabetes by integrating T2D subjects’ transcriptomic data. We computed a ‘frequently perturbed subnetwork’ in T2D that captures common perturbations across tissue types and mapped the possible effects of Metformin onto it. We then identified a set of remaining T2D perturbations and potential drug targets among them, related to oxidative stress and hypercholesterolemia. We then identified Probucol as the potential co-drug for adjunct therapy with Metformin and evaluated the efficacy of the combination in a rat model of diabetes. We find Metformin-Probucol at 5:0.5 mg/kg effective in restoring near-normal serum glucose, lipid, and cholesterol levels.
Effective dose window for containing tumor burden under tolerable level
Authors: Masud M. A. , Kim Jae-Young , Kim Eunjung 
Published: May 2023

AbstractA maximum-tolerated dose (MTD) reduces the drug-sensitive cell population, though it may result in the competitive release of drug resistance. Alternative treatment strategies such as adaptive therapy (AT) or dose modulation aim to impose competitive stress on drug-resistant cell populations by maintaining a sufficient number of drug-sensitive cells. However, given the heterogeneous treatment response and tolerable tumor burden level of individual patients, determining an effective dose that can fine-tune competitive stress remains challenging. This study presents a mathematical model-driven approach that determines the plausible existence of an effective dose window (EDW) as a range of doses that conserve sufficient sensitive cells while maintaining the tumor volume below a threshold tolerable tumor volume (TTV). We use a mathematical model that explains intratumor cell competition. Analyzing the model, we derive an EDW determined by TTV and the competitive strength. By applying a fixed endpoint optimal control model, we determine the minimal dose to contain cancer at a TTV. As a proof of concept, we study the existence of EDW for a small cohort of melanoma patients by fitting the model to longitudinal tumor response data. We performed identifiability analysis, and for the patients with uniquely identifiable parameters, we deduced patient-specific EDW and minimal dose. The tumor volume for a patient could be theoretically contained at the TTV either using continuous dose or AT strategy with doses belonging to EDW. Further, we conclude that the lower bound of the EDW approximates the minimum effective dose (MED) for containing tumor volume at the TTV.
Learning from Alfred Wegener’s pioneering field observations in West Greenland after a century of climate change
Authors: Abermann J. , Vandecrux B. , Scher S. , Löffler K. , Schalamon F. , Trügler A. , Fausto R. , Schöner W. 
Published: May 2023

AbstractThe cryosphere in Greenland is currently undergoing strong changes. While remote sensing improves our understanding of spatial and temporal changes across scales, particularly our knowledge of conditions during the pre-satellite era is fragmented. Therefore, high-quality field data from that period can be particularly valuable to better understand changes of the cryosphere in Greenland at climate time scales. At Graz University, the last work-place of Alfred Wegener we have access to the extensive expedition results from their epic 1929–1931 expedition to Greenland. The expedition coincides with the warmest phase of the Arctic early twentieth century warm period. We present an overview of the main findings of the Wegener expedition archive and set it into context with further monitoring activities that occurred since, as well as the results from reanalysis products and satellite imagery. We find that firn temperatures have increased significantly, while snow and firn densities and have remained similar or decreased since. Local conditions at the Qaamarujup Sermia have changed strongly, with a reduction in length of more than 2 km, in thickness by up to 120 m and a rise in terminus position of approximately 300 m. The elevation of the snow line of the years 1929 and 1930 was similar to the one from the extreme years 2012 and 2019. Compared to the satellite era, we find that during the time of the Wegener expedition fjord ice extent was smaller in early spring and larger in late spring. We demonstrate that a well-documented snapshot of archival data can provide a local and regional context for contemporary climate change and that it can serve as the basis for process-based studies on the atmospheric drivers of glacier changes.
Elevated risk of cervical cancer in elderly women with incident ulcerative colitis in South Korea
Authors: Kim Jihoon , Jo Halim , Ha Min Chul , Kim Hyunil , Lee Jung Kuk , Han Jae Hun , Lee San-Hui , Kang Dae Ryong , Kim Su Young , Kim Hyun-Soo , Kim Hee Man 
Published: May 2023

AbstractThe association between ulcerative colitis (UC) and uterine cervical cancer is still unclear. To investigate cervical cancer risk in South Korean women with UC, we analyzed the Korean National Health Insurance claims data. UC was defined using both ICD-10 codes and UC-specific prescriptions. We analyzed incident cases of UC diagnosed between 2006 and 2015. Age-matched women without UC (control group) were randomly selected from the general population (1:3 ratio). Hazard ratios were calculated using multivariate Cox proportional hazard regression, and the event was defined as occurrence of cervical cancer. A total of 12,632 women with UC and 36,797 women without UC were enrolled. The incidence of cervical cancer was 38.8 per 100,000 women per year in UC patients and 25.7 per 100,000 women per year in controls, respectively. The adjusted HR for cervical cancer was 1.56 (95% CI 0.97–2.50) in the UC group with reference to the control group. When stratified by age, the adjusted HR for cervical cancer was 3.65 (95% CI 1.54–8.66) in elderly UC patients (≥ 60 years) compared to elderly control group (≥ 60 years). Within UC patients, increased age (≥ 40 years) and low socioeconomic status were associated with an increased risk of cervical cancer. The incidence of cervical cancer was found to be higher among elderly patients (≥ 60 years) with newly diagnosed UC in South Korea, compared to age-matched controls. Therefore, regular cervical cancer screening is recommended for elderly patients who have recently been diagnosed with UC.
On modeling the correlates of conspiracy thinking
Authors: Enders Adam M. , Diekman Amanda , Klofstad Casey , Murthi Manohar , Verdear Daniel , Wuchty Stefan , Uscinski Joseph 
Published: May 2023

AbstractWhile a robust literature on the psychology of conspiracy theories has identified dozens of characteristics correlated with conspiracy theory beliefs, much less attention has been paid to understanding the generalized predisposition towards interpreting events and circumstances as the product of supposed conspiracies. Using a unique national survey of 2015 U.S. adults from October 2020, we investigate the relationship between this predisposition—conspiracy thinking—and 34 different psychological, political, and social correlates. Using conditional inference tree modeling—a machine learning-based approach designed to facilitate prediction using a flexible modeling methodology—we identify the characteristics that are most useful for orienting individuals along the conspiracy thinking continuum, including (but not limited to): anomie, Manicheanism, support for political violence, a tendency to share false information online, populism, narcissism, and psychopathy. Altogether, psychological characteristics are much more useful in predicting conspiracy thinking than are political and social characteristics, though even our robust set of correlates only partially accounts for variance in conspiracy thinking.
Thermal inspection for viscous dissipation slip flow of hybrid nanofluid (TiO2–Al2O3/C2H6O2) using cylinder, platelet and blade shape features
Authors: Yang Hong , Hayat Umer , Shaiq Shakil , Shahzad Azeem , Abbas Tasawar , Naeem Muhammad , Khan Sami Ullah , Labidi Taher , Kolsi Lioua , Zahid Manzoor Ahmad 
Published: May 2023

AbstractHybrid nanofluid are the modified class of nanofluids with extra high thermal performances and present different applications in automotive cooling, heat transfer devices, solar collectors, engine applications, fusion processes, machine cutting, chemical processes etc. This thermal research explores the heat transfer assessment due to hybrid nanofluid with of different shape features. The thermal inspections regarding the hybrid nanofluid model are justified with aluminium oxide and titanium nanoparticles. The base liquid properties are disclosed with ethylene glycol material. The novel impact of current model is the presentation of different shape features namely Platelets, blade and cylinder. Different thermal properties of utilized nanoparticles at various flow constraints are reported. The problem of hybrid nanofluid model is modified in view of slip mechanism, magnetic force and viscous dissipation. The heat transfer observations for decomposition of TiO2–Al2O3/C2H6O2 is assessed by using the convective boundary conditions. The shooting methodology is involved for finding the numerical observations of problem. Graphical impact of thermal parameters is observed for TiO2–Al2O3/C2H6O2 hybrid decomposition. The pronounced observations reveal that thermal rate enhanced for blade shaped titanium oxide-ethylene glycol decomposition. The wall shear force reduces for blade shaped titanium oxide nanoparticles.
Zinc chloride is effective as an antibiotic in biofilm prevention following septoplasty
Authors: Noach Noa , Lavy Eran , Reifen Ram , Friedman Michael , Kirmayer David , Zelinger Einat , Ritter Amit , Yaniv Dan , Reifen Ella 
Published: May 2023

AbstractBiofilm-state bacterial infections associated with inserted medical devices constitute a massive health and financial problem worldwide. Although bacteria exhibit significantly lower susceptibility to antibiotics in the biofilm state, the most common treatment approach still relies on antibiotics, exacerbating the phenomenon of antibiotic-resistant bacteria. In this study, we aimed to assess whether ZnCl2 coating of intranasal silicone splints (ISSs) can reduce the biofilm infections associated with the insertion of these devices and prevent the overuse of antibiotics while minimizing waste, pollution and costs. We tested the ability of ZnCl2 to prevent biofilm formation on ISS both in vitro and in vivo by using the microtiter dish biofilm formation assay, crystal violet staining, and electron and confocal microscopy. We found a significant decrease in biofilm formation between the treatment group and the growth control when ZnCl2-coated splints were placed in patients’ nasal flora. According to these results, infections associated with ISS insertion may be prevented by using ZnCl2 coating, thereby obviating the overuse and abuse of antibiotics.