bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRISPR/Cas9‐based double‐strand oligonucleotide insertion strategy corrects metabolic abnormalities in murine glycogen storage disease type‐Ia
Authors: Samanta Ananya , George Nelson , Arnaoutova Irina , Chen Hung‐Dar , Mansfield Brian C. , Hart Christopher , Carlo Troy , Chou Janice Y. 
Published: July 2023

AbstractGlycogen storage disease type‐Ia (GSD‐Ia), characterized by impaired blood glucose homeostasis, is caused by a deficiency in glucose‐6‐phosphatase‐α (G6Pase‐α or G6PC). Using the G6pc‐R83C mouse model of GSD‐Ia, we explored a CRISPR/Cas9‐based double‐strand DNA oligonucleotide (dsODN) insertional strategy that uses the nonhomologous end‐joining repair mechanism to correct the pathogenic p.R83C variant in G6pc exon‐2. The strategy is based on the insertion of a short dsODN into G6pc exon‐2 to disrupt the native exon and to introduce an additional splice acceptor site and the correcting sequence. When transcribed and spliced, the edited gene would generate a wild‐type mRNA encoding the native G6Pase‐α protein. The editing reagents formulated in lipid nanoparticles (LNPs) were delivered to the liver. Mice were treated either with one dose of LNP‐dsODN at age 4 weeks or with two doses of LNP‐dsODN at age 2 and 4 weeks. The G6pc‐R83C mice receiving successful editing expressed ~4% of normal hepatic G6Pase‐α activity, maintained glucose homeostasis, lacked hypoglycemic seizures, and displayed normalized blood metabolite profile. The outcomes are consistent with preclinical studies supporting previous gene augmentation therapy which is currently in clinical trials. This editing strategy may offer the basis for a therapeutic approach with an earlier clinical intervention than gene augmentation, with the additional benefit of a potentially permanent correction of the GSD‐Ia phenotype.
Effect of selected agents for ochratoxin A biocontrol on the colour, texture and volatile profile of dry‐cured fermented sausages
Authors: Álvarez Micaela , Núñez Félix , Cebrián Eva , Roncero Elia , Andrade María Jesús 
Published: July 2023

AbstractBACKGROUNDTraditional dry‐cured fermented sausages favour the growth of an autochthonous microbial population, which plays an important role in their sensory aspects. However, some moulds can produce mycotoxins such as ochratoxin A (OTA). The biocontrol agents (BCAs) Debaryomyces hansenii FHSCC 253H and Staphylococcus xylosus FHSCC Sx8 have been demonstrated to reduce OTA production in dry‐cured meat products, but their influence in the sensory characteristics of sausages has to be tested. The aim of this study was to evaluate the effect of these BCAs on the colour, texture and volatile profile of dry‐cured fermented sausages.RESULTSD. hansenii caused few differences in the tested parameters with respect to the control batch. S. xylosus modified the texture and colour, although the values found were within the range expected for dry‐cured fermented sausages ‘salchichón’. Additionally, the volatile profile revealed the potential antioxidant effect of both BCAs and their ability to produce compounds associated with the ripened aroma that could increase product acceptability.CONCLUSIONThe results indicate that there were no inconveniences in implementing both BCAs during the processing of dry‐cured fermented sausages ‘salchichón’. Moreover, D. hansenii FHSCC 253H could improve the volatile profile of this product. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Does the intention to purchase cause‐related products compared to charity donations indicate higher morality?
Authors: Adomaviciute Karina , Urbonavicius Sigitas 
Published: July 2023

AbstractThe growing competition among charity organizations provides individuals with a wide selection of ways how to support specific social causes. Donations to charity and purchase of cause‐related products are two forms of pro‐social behaviors that receive the most attention from researchers and practitioners. Though their aim (to help others) and many characteristics of campaigns are similar, usually these behaviors and factors affecting them are studied separately, using different theoretical backgrounds. This paper aims to investigate these two behaviors together on the basis of identity theory and analyze how moral identity and moral emotions impact them. Based on a survey of 571 respondents, SEM analysis disclosed the positive impact of the moral identity dimension internalization on the intention to purchase cause‐related products (a private prosocial act), whereas the impact of the symbolization dimension on the intention to donate (a public prosocial act) was not revealed. The results also show that purchase intentions of a cause‐related product are influenced by empathy, while donation intentions are influenced by guilt. The results indicate that although both behaviors can be explained using the same theoretical background (identity theory), the factors triggering them vary. Additionally, this study proposes several implications for non‐profit organizations and cause‐related marketing campaigns on how to make charity advertisements more appealing and increase consumers' direct and indirect donations.
Boosting Material Utilization via Direct Growth of Zn2(V3O8)2 on the Carbon Cloth as a Cathode to Achieve a High‐Capacity Aqueous Zinc‐Ion Battery
Authors: Ren Jie , Ran Yan , Yang Zhi Chao , Zhao Huaping , Wang Yude , Lei Yong 
Published: July 2023

AbstractAqueous zinc‐ion batteries (AZIBs) have attracted the attention of researchers because of their high theoretical capacity and safety. Among the many vanadium‐based AZIB cathode materials, zinc vanadate is of great interest as a typical phase in the dis‐/charge process. Here, a remarkable method to improve the utilization rate of zinc vanadate cathode materials is reported. In situ growth of Zn2(V3O8)2 on carbon cloth (CC) as the cathode material (ZVO@CC) of AZIBs. Compared with the Zn2(V3O8)2 cathode material bonded on titanium foil (ZVO@Ti), the specific capacity increases from 300 to 420 mAh g−1, and the utilization rate of the material increases from 69.60% to 99.2%. After the flexible device is prepared, it shows the appropriate specific capacity (268.4 mAh g−1 at 0.1 A g−1) and high safety. The method proposed in this work improves the material utilization rate and enhances the energy density of AZIB and also has a certain reference for the other electrochemical energy storage devices.
A Generalization of Szep’s Conjecture for Almost Simple Groups
Authors: Gill Nick , Giudici Michael , Spiga Pablo 
Published: July 2023

AbstractWe prove a natural generalization of Szep’s conjecture. Given an almost simple group G with socle not isomorphic to an orthogonal group having Witt defect zero, we classify all possible group elements $$x,y\in G\setminus \{1\}$$

x
,
y
∈
G
\
{
1
}

with $$G=\textbf{N}_G(\langle x\rangle )\textbf{N}_G(\langle y\rangle )$$

G
=

N
G

(

⟨
x
⟩

)

N
G

(

⟨
y
⟩

)

, where we are denoting by $$\textbf{N}_G(\langle x\rangle )$$

N
G

(

⟨
x
⟩

)

and by $$\textbf{N}_G(\langle y\rangle )$$

N
G

(

⟨
y
⟩

)

the normalizers of the cyclic subgroups $$\langle x\rangle $$

⟨
x
⟩

and $$\langle y\rangle $$

⟨
y
⟩

. As a consequence of this result, we classify all possible group elements $$x,y\in G\setminus \{1\}$$

x
,
y
∈
G
\
{
1
}

with $$G=\textbf{C}_G(x)\textbf{C}_G(y)$$

G
=

C
G

(
x
)

C
G

(
y
)

.
Unterrichtliche Transformationsforschung – Formen bildsamer Erfahrung im schulischen Unterricht
Authors: Lipkina Julia , Yacek Douglas 
Published: July 2023

ZusammenfassungDer Beitrag setzt sich kritisch mit jüngsten Versuchen, die pädagogischen und unterrichtlichen Implikationen eines transformatorischen Bildungsbegriffs auszuarbeiten auseinander und problematisiert die Annahme, dass bildsame, transformative Erfahrungen im Unterricht lediglich unter dem Vorzeichen von Krisen und Irritationen initiiert werden können. Vor dem Hintergrund der Kritik am Konzept transformatorischer Bildung und seiner didaktischen Anwendung stellt der Beitrag alternative Ansätze vor, die es erlauben, die transformativen Momente im Unterricht jenseits von Krisen und Irritationen diskutieren zu können. In den Blick kommen dabei drei alternative Genren bildsamer Erfahrung, welche in den letzten fünf Jahren einen zunehmenden Einfluss auf die internationale bildungstheoretische Debatte ausgeübt haben: Die Begriffe der Artikulation (Taylor), der Resonanz (Rosa) und der Aspiration (Callard) werden in diesem Zuge erläutert und anschließend auf ihre Vor- und Nachteile für einetransformationssensibleUnterrichtsforschung geprüft. Ziel ist die Entwicklung eines analytischen Vokabulars, um im Rahmen einer bildungstheoretisch fundierten Unterrichtsforschung transformative Wirkungen des Unterrichts empirisch in den Blick nehmen zu können. Dabei zeigt sich, dass die unterschiedliche Erfahrungsformen – trotz mannigfacher Schwerpunktsetzungen und philosophischer Grundlegungen – in eingegenseitiges Ergänzungsverhältnisgebracht werden können, das einen besonderen empirischen Zugang zur Rekonstruktion der transformativen Momente des Unterrichts ermöglichen kann.
Miller Fischer syndrome after COVID-19 infection and vaccine: a systematic review
Authors: Neophytou Panayiota , Artemiadis Artemios , Hadjigeorgiou Georgios M. , Zis Panagiotis 
Published: July 2023

AbstractBackgroundCOVID-19 (CoranaVirus disease 2019) is an ongoing infectious disease caused by the RNA SARS-CoV-2 virus (Severe Acute Respiratory Syndrome CoronaVirus-2). The virus mainly causes respiratory symptoms, but neurological symptoms have also been reported to be part of the clinical manifestations of the disease. The aim of this study was to systematically review Miller fisher syndrome (MFS) published cases, in the context of COVID-19 infection or vaccination.MethodsA systematic literature review on Medline was performed. A total of 21 papers were included in the present review.ResultsTwenty-two MFS cases (77% males) were identified, 14 related to COVID-19 infection and 8 to vaccination against COVID-19. The median age of the adult patients was 50 years (interquartile range 36–63 years). Sixteen patients (73%) had the classic triad of MFS (ophthalmoplegia, ataxia, areflexia), four (18%) had acute ophthalmoplegia and one other characteristic symptom and two patients (9%) had only one other characteristic symptom, but they tested positive for GQ1b antibodies. Nine (41%) patients had positive GQ1b antibodies and were classified as “definite” MFS. Albuminocytologic dissociation was found in half of the cases. The outcome was favourable in the majority of cases (86%) whereas one patient, despite the initial improvement, died because of a cardiac arrest, after cardiac arrythmia.ConclusionsMFS after COVID-19 infection/vaccination was found to have the typical epidemiological characteristics of classic MFS; being rare, occurring more often after infection than vaccination, affecting mainly middle-aged males usually within 3 weeks after the event and having an excellent prognosis after treatment with IVIG or even with no treatment at all. We found no evidence that MFS after COVID-19 infection was different from MFS after COVID-19 vaccination, although the former tended to occur earlier.
Enantioselective catalytic Strecker reaction on cyclic (Z)-aldimines in flow: reaction optimization and sustainability aspects
Authors: Alfano Antonella Ilenia , Sorato Andrea , Ciogli Alessia , Lange Heiko , Brindisi Margherita 
Published: July 2023

AbstractCatalytic enantioselective Strecker reactions on an achiral substrate using sub-stoichiometric amounts of a chiral catalyst represent an evolving key strategy for the effective synthesis of α-amino nitriles. We herein disclosed the set-up of a flow-based methodology for enantioselective Strecker, employing ethyl cyanoformate as a relatively safe cyanide source, a cinchona-based catalyst, and methanol as additive. A thorough exploration of key parameters allowed the identification of the most efficient reagent mixing mode, the optimum solvent for the flow synthesis, minimum catalyst loading, additive, temperature, and residence time. The newly developed method allows straightforward reaction channeling towards the fast and complete formation of the α-amino nitrile products, thus reducing the yield drop due to indolenine degradation during long-lasting batch-wise reactions. Moreover, we herein provide preliminary hints for sustainability, by proposing a simple procedure for catalyst recycling, thus opening the way for further optimization of the proposed methodology.
Graphical Abstract
Evaluation of a commercial electrical stunning method for farmed grower saltwater crocodiles (Crocodylus porosus) using non-invasive EEG measurements
Authors: Small Alison , Niemeyer Dominic , Hewitt Leisha 
Published: July 2023

Abstract
The aim of this study was to assess welfare outcomes of electrical stunning as a means of restraint in farmed grower saltwater crocodiles (Crocodylus porosus). Physical handling of a stunned, unconscious crocodile is far safer for the operator than handling a fully conscious animal. Electroencephalogram (EEG) was recorded before and after the application of electrical stunning at 50 Hz or 400 Hz using an electrical stunner applied to the cranial plate (Position 1: P1–50 Hz; n = 31, P1–400 Hz; n = 29) or immediately behind the skull (Position 2: P2–50 Hz; n = 29; P2–400 Hz; n = 30). For all electrical stuns, percentage total EEG power in a 10-s epoch decreased in the alpha and beta frequency bands; and increased in the delta and lower frequencies bands. All electrical stuns resulted in increased strength of signal, based on the quadratic mean EEG power in all frequency bands of the EEG. Greatest change in power occurred in the delta frequency band, with P1–50 Hz. This was greater than with P2–50 Hz; while decibel change using 400 Hz at either position was intermediate and not significantly different from either. Application of either electrical stunner at position 1 resulted in seizure-like activity and activation in low frequencies, but at position 2 this was not consistent across all animals. The ability of the electrical stunning equipment to consistently induce recoverable unconsciousness could be ranked in decreasing order as: P1–50 Hz > P1–400 Hz = P2–50 Hz > P2–400 Hz. Based on behavioural observations, all animals in the study appeared to stunned however evaluation of duration of EEG changes indicates that use of the electrical stunning equipment at 50 Hz would allow some margin for inaccuracies in tong placement, while achieving a consistently reliable stun.
Targeted Nativism: Ethnic Diversity and Radical Right Parties in Europe
Authors: Svraka Dragana 
Published: July 2023

AbstractRadical right parties are commonly associated with nativism and opposition to ethnic diversity, but there have been few systematic attempts to investigate this connection further. Noting that radical right parties in Europe do not express hostility towards all minorities or all immigrants, I investigate possible explanations for the difference in targeted hostility. I introduce the concept of targeted nativism, distinguishing between ethnic minorities that are excluded using the nativist cleavage, and those that are implicitly included in ‘the nation’. I propose three explanations for the targeted nativism, identifying minority outgroups based on: (1) ethnocultural differences, (2) minority political empowerment, or (3) ethnocultural minority accommodation. I examine these explanations using the examples of radical right parties in Sweden and Bulgaria, and further test these hypotheses with a new dataset that identifies targeted minorities. My findings indicate that more distinctive minorities are significantly more likely to be targeted by the radical right.
Disinfection efficacy of Oxivir TB wipe residue on severe acute respiratory coronavirus virus 2 (SARS-CoV-2)
Authors: Graves Amanda M. , Barrett Aaron , Addison Bechtler , Polage Christopher R. , Smith Becky A. , Lewis Sarah , Anderson Deverick J. , Warren Bobby G. ,   for the CDC Prevention Epicenters Program
Published: July 2023

AbstractWe assessed Oxivir Tb wipe disinfectant residue in a controlled laboratory setting to evaluate low environmental contamination of SARS-CoV-2. Frequency of viral RNA detection was not statistically different between intervention and control arms on day 3 (P=0.14). Environmental contamination viability is low; residual disinfectant did not significantly contribute to low contamination.
Efficacy of virtual reality-based exposure therapy for the treatment of fear of flying: a systematic review
Authors: Ribé-Viñes J.M. , Gutiérrez-Maldonado J. , Zabolipour Zahra , Ferrer-Garcia M. 
Published: July 2023

Abstract
Previous research has shown that virtual reality (VR)-based exposure therapy is effective in the treatment of anxiety disorders. However, more information regarding the specific features of this intervention for the treatment of fear of flying (FoF) is needed. The primary aim of this systematic review was to update and analyse the existing data on the efficacy of VR exposure treatment (VRET) in FoF, providing information on the optimal methodological conditions for its administration. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method was employed to select the articles. PsycInfo, Medline and Web of Science were chosen as databases with a wide range of publications related to health and psychology. Thirty-three eligible articles were included in this review. Results showed that participants’ anxiety decreased after being systematically exposed to flight-related VR environments. VRET is at least as effective as other evidence-based treatments, such as cognitive behavioural therapy (CBT) or in vivo exposure therapy (IVET), and therefore is a highly recommended alternative when IVET is difficult to administer, and an excellent complement to enhance CBT efficacy. Regarding sensory cues, the addition of motion feedback synchronised with visual and auditory cues during the exposure to VR environments might improve the efficacy of VRET for FoF, but more research supporting this statement is still needed.
An Energetic Eruption With Associated SO 1.707 Micron Emissions at Io's Kanehekili Fluctus and a Brightening Event at Loki Patera Observed by JWST
Authors: de Pater Imke , Lellouch Emmanuel , Strobel Darrell F. , de Kleer Katherine , Fouchet Thierry , Wong Michael H. , Holler Bryan J. , Stansberry John , Fry Patrick M. , Brown Michael E. , Bockelée‐Morvan Dominique , Trumbo Samantha K. , Fletcher L. N. , Hedman Matthew M. , Molter Edward M. , Showalter Mark , Tiscareno Matthew S. , Cazaux Stéphanie , Hueso Ricardo , Luszcz‐Cook Statia , Melin Henrik , Moeckel Chris , Mura Alessandro , Orton Glenn , Roth Lorenz , Saur Joachim , Tosi Federico 
Published: July 2023

AbstractWe observed Io with the James Webb Space Telescope (JWST) while the satellite was in eclipse, and detected thermal emission from several volcanoes. The data were taken as part of our JWST‐ERS program #1373 on 15 November 2022. Kanehekili Fluctus was exceptionally bright, and Loki Patera had most likely entered a new brightening phase. Spectra were taken with NIRSpec/IFU at a resolving power R ≈ 2,700 between 1.65 and 5.3 µm. The spectra were matched by a combination of blackbody curves that showed that the highest temperature, ∼1,200 K, for Kanehekili Fluctus originated from an area ∼0.25 km2 in size, and for Loki Patera this high temperature was confined to an area of ∼0.06 km2. Lower temperatures, down to 300 K, cover areas of ∼2,000 km2 for Kanehekili Fluctus, and ∼5,000 km2 for Loki Patera. We further detected the a1Δ ⇒ X3Σ− 1.707 µm rovibronic forbidden SO emission band complex over the southern hemisphere, which peaked at the location of Kanehekili Fluctus. This is the first time this emission has been seen above an active volcano, and suggests that the origin of such emissions is ejection of SO molecules directly from the vent in an excited state, after having been equilibrated at temperatures of ∼1,500 K below the surface, as was previously hypothesized.
Depressive symptoms, anxiety and cognitive impairment: emerging evidence in multiple sclerosis
Authors: Margoni Monica , Preziosa Paolo , Rocca Maria A. , Filippi Massimo 
Published: July 2023

AbstractNeuropsychiatric abnormalities may be broadly divided in two categories: disorders of mood, affect, and behavior and abnormalities affecting cognition. Among these conditions, clinical depression, anxiety and neurocognitive disorders are the most common in multiple sclerosis (MS), with a substantial impact on patients’ quality of life and adherence to treatments. Such manifestations may occur from the earliest phases of the disease but become more frequent in MS patients with a progressive disease course and more severe clinical disability. Although the pathogenesis of these neuropsychiatric manifestations has not been fully defined yet, brain structural and functional abnormalities, consistently observed with magnetic resonance imaging (MRI), together with genetic and immunologic factors, have been suggested to be key players. Even though the detrimental clinical impact of such manifestations in MS patients is a matter of crucial importance, at present, they are often overlooked in the clinical setting. Moreover, the efficacy of pharmacologic and non-pharmacologic approaches for their amelioration has been poorly investigated, with the majority of studies showing marginal or no beneficial effect of different therapeutic approaches, possibly due to the presence of multiple and heterogeneous underlying pathological mechanisms and intrinsic methodological limitations. A better evaluation of these manifestations in the clinical setting and improvements in the understanding of their pathophysiology may offer the potential to develop tools for differentiating these mechanisms in individual patients and ultimately provide a principled basis for treatment selection. This review provides an updated overview regarding the pathophysiology of the most common neuropsychiatric symptoms in MS, the clinical and MRI characteristics that have been associated with mood disorders (i.e., depression and anxiety) and cognitive impairment, and the treatment approaches currently available or under investigation.
Epidemiology and clinical characteristics of interstitial lung disease in patients with rheumatoid arthritis from the JointMan database
Authors: Zhuo Joe , Lama Sonie , Knapp Keith , Gutierrez Cynthia , Lovett Kate , Thai Sydney , Craig Gary L. 
Published: July 2023

AbstractInterstitial lung disease (ILD) is a progressive fibrotic disease associated with rheumatoid arthritis (RA); real-world data for evaluating RA–associated ILD (RA–ILD) are limited. We evaluated prevalence, time to onset, clinical characteristics and prognostic factors in patients diagnosed with RA (n = 8963) in the Discus Analytics JointMan database (2009–2019) with and without ILD. ILD prevalence was 4.1% (95% confidence interval 3.7–4.5); > 90% had an ILD diagnosis after RA diagnosis (mean time to onset 3.3 years). At baseline, a higher proportion of patients with RA–ILD were older (> 65 years), male, with history of chronic obstructive pulmonary disease (COPD) compared with patients in the RA cohort. Patients in the RA–ILD cohort were likely to have more severe RA characteristics and joint evaluation compared with patients without ILD, at baseline and before/after ILD diagnosis. In this large, real-world database patients with (vs without) ILD had a higher burden of RA characteristics. Previously established risk factors for RA–ILD were confirmed (age, baseline COPD, anti-cyclic citrullinated peptide positivity, C-reactive protein, Clinical Disease Activity Index score); thus, recognition of these factors and tracking routine disease activity metrics may help identify patients at higher risk of RA complications and lead to improved diagnosis and earlier treatment.