bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Trans-Atlantic Order to Afro-Eur-Asian Worlds? Reimagining International Relations as Interlocking Regional Worlds
Authors: Fisher-Onar Nora , Kavalski Emilian 
Published: January 2023

AbstractThe apparent transition underway from a trans-Atlantic, liberal world order to one of multiple, overlapping orders has caused much policy, scholarly, and public anxiety. In tandem with this structural development, in the field of international relations (IR), heated contests are underway between alternative visions of how to read this transformation. In this introduction to the special forum, we outline an approach for grappling with these dynamics. Our overarching question is: How to make sense of emergent regional imaginaries, the ways that they interlock, and the implications for IR theory and practice? To begin answering, we first challenge the increasingly widespread view that the return of great power politics—or what we call the “great game” vision of multipolarity—is the only or best register with which to read emerging patterns. Instead, we propose the idea of “interlocking regional worlds,” a notion inspired by “Afro-Eur-Asia” as a site that evokes multiple meanings. A historically sensitive and sociologically nuanced analytical modality, we argue for theory as “itinerant translation” across regional worlds. This relational framework, we contend, can help to better understand and explain, observe and encounter one another, the problems that collectively embroil us, and the transformative processes to which we are bearing witness. The exercises in itinerant translation across the interlocking regional worlds of Afro-Eur-Asia on offer in this special forum likewise reveal the globe as a pluriversal space where multiple realities can and do coexist (and always have).
Skin for Skin: Biblical Language in Jamaica’s Morant Bay Rebellion
Authors: Russell Stephen C 
Published: January 2023

AbstractIn October, 1865, Paul Bogle and a few hundred Black residents of rural Jamaica rebelled against the vagaries of an overly zealous magistrate. They set the courthouse at Morant Bay on fire and killed over a dozen people, mostly white. In the savage government reprisals that followed, over 430 Black Jamaicans were executed. Here, I observe how biblical language played a central role in public discourse about the rebellion. I focus on the rebellion’s slogan: skin for skin. I trace the interpretive history of this phrase drawn from the book of Job, showing how it became associated with advocacy for Black rights. And I examine the social context of Bogle’s use of the phrase to call for a Black alliance that crossed ethnic, religious, and class lines. I thus further a critical trajectory that has recognized the importance of biblical language to race talk in the age of emancipation.
Identification of outcomes reported for hospital antimicrobial stewardship interventions using a systematic review of reviews
Authors: Yousuf Shazia , Rzewuska Magdalena , Duncan Eilidh , Ramsay Craig 
Published: January 2023

Abstract

Background
Randomized trials of hospital antimicrobial stewardship (AMS) interventions aimed to optimize antimicrobial use contribute less to the evidence base due to heterogeneity in outcome selection and reporting. Developing a core outcome set (COS) for these interventions can be a way to address this problem. The first step in developing a COS is to identify and map all outcomes.

Objectives
To identify outcomes reported in systematic reviews of hospital AMS interventions.

Methods
Cochrane Database of Systematic Reviews, MEDLINE and Embase were searched for systematic reviews published up until August 2019 of interventions relevant to reducing unnecessary antimicrobial use for inpatient populations in secondary care hospitals. The methodological quality of included reviews was assessed using AMSTAR-2, A (revised) MeaSurement Tool to Assess systematic Reviews. Extracted outcomes were analysed using deductive and inductive thematic analysis. A list of overarching (unique) outcomes reflects the outcomes identified within the systematic reviews.

Results
Forty-one systematic reviews were included. Thirty-three (81%) systematic reviews were of critically low or low quality. A long list of 1739 verbatim outcomes was identified and categorized under five core areas of COMET (Core Outcome Measures in Effectiveness Trials) taxonomy: ‘resources use’ (45%), ‘physiological/clinical’ (27%), ‘life impact’ (16%), ‘death’ (8%) and ‘adverse events’ (4%). A total of 421 conceptually different outcomes were identified and grouped into 196 overarching outcomes.

Conclusions
There is significant heterogeneity in outcomes reported for hospital AMS interventions. Reported outcomes do not cover all domains of the COMET framework and may miss outcomes relevant to patients (e.g. emotional, social functioning, etc.). The included systematic reviews lacked methodological rigour, which warrants further improvements.
Vitamin C Status of US Adults Assessed as Part of the National Health and Nutrition Examination Survey Remained Unchanged between 2003–2006 and 2017–2018
Authors: Powers Carissa D , Sternberg Maya R , Patel Sweta B , Pfeiffer Christine M , Storandt Renee J , Schleicher Rosemary L 
Published: January 2023

Abstract

Background
We compared serum vitamin C (VIC) status of the adult (≥20 y) US population in the National Health and Nutrition Examination Survey (NHANES) 2017–2018 with combined data from 2003–2004 and 2005–2006.

Methods
VIC was measured using HPLC with electrochemical detection. Mean data were stratified by age, sex, race/Hispanic origin, income, body mass index, dietary intake, supplement use, and smoking status. Prevalence of VIC deficiency (&lt;11.4 μmol/L) was calculated.

Results
In NHANES 2017–2018, the mean VIC was 8 μmol/L higher in people ≥60 y compared with those 20–59 y of age, 10 μmol/L lower in men vs women, 8 μmol/L lower in low vs high income, 11 μmol/L lower in obese vs healthy weight, and 15 μmol/L lower in smokers vs nonsmokers. Differences in mean VIC across race/Hispanic origin groups ranged from 2 to 7 μmol/L. Mean VIC was 27 μmol/L higher with vitamin C-containing supplement use and positively associated (Spearman ρ = 0.33; P &lt; 0.0001) with increasing dietary intake. The associations between mean VIC and the investigated covariates were generally consistent and the prevalence of deficiency was not significantly different between survey periods (6.8% vs 7.0%; P = 0.83). However, a few subgroups had double the risk. We found no significant survey differences in mean VIC (51.2 vs 54.0 μmol/L; P = 0.09).

Conclusions
Overall VIC status of the US adult population has remained stable since last assessed in the NHANES 2005–2006 survey. Vitamin C deficiency remained high for those with low dietary intake and who smoke.
Comparison of Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma on Pressure Ulcer in a Rat Model
Authors: Yuan Ze , Wang Yanxue , Li Yudan , Lin Caina , Wang Shaoling , Wang Junchao , Ma Chao , Wu Shaoling 
Published: January 2023

Abstract
Pressure ulcer (PU) is a common type of chronic wound that is difficult to treat. Platelet-rich plasma (PRP) is rich in cytokines and growth factors, and it can be divided into two categories according to its leukocyte content: leukocyte-poor PRP (P-PRP) and leukocyte-rich PRP (L-PRP). PRP has been applied in a variety of wound treatments, due to its strong ability to promote repair. This study aims to investigate the therapeutic effects of PRP on PU and elucidate the role of leukocytes in the treatment process. Sprague-Dawley rats were used to establish PU models of ischemia–reperfusion injury by applying magnets externally. L-PRP, P-PRP, and saline were injected into the dermal wounds. Wound healing analysis and sampling were performed on days 3, 7, 11, and 15 after treatment. Histological examinations, real-time PCR, immunohistochemical examinations, and biomechanical assay were carried out on the wound samples. The PRP groups exhibited greater wound inflammatory response than the control group in the early stage but the response reduced rapidly as the wound healed. On days 7, 11, and 15, the PRP groups also yielded better wound healing rates and histological outcomes than the control group, with superior biomechanical properties observed on day 15. Among both PRP groups, the L-PRP group attained a higher wound healing rate than the P-PRP group on day 7, with greater significant early inflammatory responses, and more prominent angiogenesis. Therefore, PRP is proven to accelerate the healing of PU, with L-PRP being more effective in regulating inflammation and promoting angiogenesis than P-PRP.
Exploring Music Therapy Research in Preschool Settings that Include Children with Disabilities: A Scoping Review
Authors: Birch Joshua , Thompson Grace 
Published: January 2023

Abstract
With an increasing number of developed nations adopting elements of the social model of disability, early childhood intervention practice has evolved to place greater emphasis on an inclusive, ecological, and strength-based framework. Recent music therapy literature seems to align with this shift in policy and demonstrates how family-centered strategies can be promoted in homes. Although music therapy researchers have conducted studies in kindergartens and childcares, which are also fundamental naturalistic settings for children with disabilities, the overall breadth and nature of practice in these settings is unclear and has not been collated. This scoping review aims to identify the key characteristics of music therapy research in preschool settings that include children with disabilities, subsequently identifying key publication details, participants, therapeutic aims, outcome measures, study designs, preschool settings, delivery models, and choice of music therapy methods. A total of 19 peer-reviewed journal articles from 1988 to 2020 met inclusion and exclusion criteria, with more than half of the studies published during the last 15 years. Evaluation of these 19 studies reveals how funding policies and educational systems seem to inherently inform the application of music therapy research in early learning centers. Developmental perspectives and objectivist study designs underpin many of the included sources, with majority of the outcomes demonstrating music therapy’s positive impact upon a child’s development. Researchers outside of the United States should give greater focus to early childhood and collect data from preschools within their respective countries to broaden awareness on how music therapy can support children with disabilities in naturalistic settings.
Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions
Authors: Honda Hiroyuki , Yoshimura Motoi , Arahata Hajime , Yagita Kaoru , Sadashima Shoko , Hamasaki Hideomi , Shijo Masahiro , Koyama Sachiko , Noguchi Hideko , Sasagasako Naokazu 
Published: January 2023

Abstract
Fused in sarcoma (FUS), coded by FUS, is a heterogeneous nuclear ribonucleoprotein (hnRNP). FUS mutations are among the major mutations in familial amyotrophic lateral sclerosis (ALS-FUS: ALS6). The pathological hallmarks of ALS-FUS are FUS-positive neuronal cytoplasmic inclusions (NCI). We examined various hnRNPs in FUS NCIs in the hippocampus in ALS-FUS cases with different FUS mutations (Case 1, H517P; Case 2, R521C). We also examined TDP43-positive NCIs in sporadic ALS hippocampi. Immunohistochemistry was performed using primary antibodies against FUS, p-TDP43, TDP43, hnRNPA1, hnRNPD, PCBP1, PCBP2, and p62. Numerous FUS inclusions were found in the hippocampal granule and pyramidal cell layers. Double immunofluorescence revealed colocalization of FUS and p-TDP43, and FUS and PCBP2 (p-TDP43/FUS: 64.3%, PCBP2/FUS: 23.9%). Colocalization of FUS and PCBP1, however, was rare (PCBP1/FUS: 7.6%). In the hippocampi of patients with sporadic ALS, no colocalization was observed between TDP43-positive inclusions and other hnRNPs. This is the first study to show that FUS inclusions colocalize with other hnRNPs, such as TDP43, PCBP2, and PCBP1. These findings suggest that in ALS-FUS, FUS inclusions are the initiators, followed by alterations of multiple other hnRNPs, resulting in impaired RNA metabolism.
Mine Air Makes Free? Rural Liberty, Materiality, and Agency in Europe’s Long Thirteenth Century
Authors: Geltner G 
Published: January 2023

Abstract
Mines and miners began to proliferate in Europe from the late twelfth century on, in lockstep with the region’s accelerating economic integration and urbanization. Mining communities were often rural and remote, reflecting landlords’ capacity to attract workers through freedoms that echoed the era’s incentives for urban migration. If, according to the adage, “city air makes free,” so apparently did the mine. Yet the specific affordances of mines’ materiality, and the mobility regimes they fostered, shaped distinct social dynamics. These emerge in their complexity when mining ordinances—a new type of legal subgenre—are explored for their handling of matter and movement. Mining legislation attests that the composition of ores, the underground extension of seams, the quality of available tools, and the behavior of gas, water, and air across different topographies were salient factors over which elites had little control. The raw physical constraints on directing the flow of people and matter into, through, and out of mines thus created a network of subterranean agency that translated under certain conditions into exterranean power.
Progress on the antiferromagnetic topological insulator MnBi2Te4
Authors: Li Shuai , Liu Tianyu , Liu Chang , Wang Yayu , Lu Hai-Zhou , Xie X C 
Published: January 2023

ABSTRACT
Topological materials, which feature robust surface and/or edge states, have now been a research focus in condensed matter physics. They represent a new class of materials exhibiting nontrivial topological phases, and provide a platform for exploring exotic transport phenomena, such as the quantum anomalous Hall effect and the quantum spin Hall effect. Recently, magnetic topological materials have attracted considerable interests due to the possibility to study the interplay between topological and magnetic orders. In particular, the quantum anomalous Hall and axion insulator phases can be realized in topological insulators with magnetic order. MnBi2Te4, as the first intrinsic antiferromagnetic topological insulator discovered, allows the examination of existing theoretical predictions; it has been extensively studied, and many new discoveries have been made. Here we review the progress made on MnBi2Te4 from both experimental and theoretical aspects. The bulk crystal and magnetic structures are surveyed first, followed by a review of theoretical calculations and experimental probes on the band structure and surface states, and a discussion of various exotic phases that can be realized in MnBi2Te4. The properties of MnBi2Te4 thin films and the corresponding transport studies are then reviewed, with an emphasis on the edge state transport. Possible future research directions in this field are also discussed.
New insights into the mucosal immune pathogenesis of IgA nephropathy from the perspective of COVID-19 vaccination
Authors: Ma Yaohui , Huang Yan , Xu Gaosi 
Published: January 2023

AbstractLarge-scale SARS-CoV-2 vaccination is one of the key strategies to curb the COVID-19 pandemic; however, there are increasing reports of IgA nephropathy following COVID-19 vaccination. The clinical manifestation, treatment and prognostic effects are different in IgAN patients who have had an onset after the first and second dose of vaccination, as well as new and recurrent IgAN patients. These conditions bring about a relatively important window for understanding the pathogenesis of IgAN. Gd-IgA1 is the core of the pathogenesis of IgAN. Most IgA is produced at mucosal sites; however, antigen-activated Toll-like receptor activation pathways expressed by antigen-presenting cells and B-cell homing receptors are different in the intestinal and respiratory mucosa, and the link between respiratory and intestinal mucosa is not well understood in the pathogenesis of IgAN. Budesonide treatment of IgAN is thought to inhibit the intestinal immune response by binding to glucocorticoid receptors in the intestinal mucosa or submucosa; however, it is unclear whether there is a therapeutic effect in respiratory mucosa-derived IgA nephropathy. The present review firstly described the relationship between the gut and respiratory mucosa, and the differences in antigen-presenting cell activation pathways and B-cell homing from the perspective of COVID-19 vaccines.
Discovery of novel Mamastroviruses in Bactrian camels and dromedaries reveals complex recombination history
Authors: Qureshi Muhammad I , Worthington Brian M , Liu Yongmei , Cheung William Y.-M , Su Shuo , Zheng Zuoyi , Li Lifeng , Lam Tommy T -Y , Guan Yi , Zhu Huachen 
Published: January 2023

Abstract
Virus emergence may occur through interspecies transmission and recombination of viruses coinfecting a host, with potential to pair novel and adaptive gene combinations. Camels are known to harbor diverse ribonucleic acid viruses with zoonotic and epizootic potential. Among them, astroviruses are of particular interest due to their cross-species transmission potential and endemicity in diverse host species, including humans. We conducted a molecular epidemiological survey of astroviruses in dromedaries from Saudi Arabia and Bactrian camels from Inner Mongolia, China. Herein, we deployed a hybrid sequencing approach coupling deep sequencing with rapid amplification of complementary deoxyribonucleic acid ends to characterize two novel Bactrian and eight dromedary camel astroviruses, including both partial and complete genomes. Our reported sequences expand the known diversity of dromedary camel astroviruses, highlighting potential recombination events among the astroviruses of camelids and other host species. In Bactrian camels, we detected partially conserved gene regions bearing resemblance to human astrovirus types 1, 4, and 8 although we were unable to recover complete reading frames from these samples. Continued surveillance of astroviruses in camelids, particularly Bactrian species and associated livestock, is highly recommended to identify patterns of cross-species transmission and to determine any epizootic threats and zoonotic risks posed to humans. Phylogenomic approaches are needed to investigate complex patterns of recombination among the astroviruses and to infer their evolutionary history across diverse host species.
Programmed intermittent bolus infusion vs. continuous infusion for erector spinae plane block in video-assisted thoracoscopic surgery
Authors: Taketa Yasuko , Takayanagi Yuki , Irisawa Yumi , Fujitani Taro 
Published: January 2023

BACKGROUNDThe optimal form of administration for erector spinae plane block has not been established.OBJECTIVETo compare the efficacy of programmed intermittent bolus infusion (PIB) and continuous infusion for erector spinae plane block.DESIGNA prospective, randomised, double-blind study.SETTINGA single centre between June 2019 and March 2020.PATIENTSIncluded patients had an American Society of Anesthesiologists physical status 1 to 3 and were scheduled for video-assisted thoracic surgery.INTERVENTIONSPatients were randomised to receive continuous infusion (0.2% ropivacaine 8 ml h−1; Group C) or PIB (0.2% ropivacaine 8 ml every 2 h; Group P).MAIN OUTCOME MEASURESThe primary outcome was the number of desensitised dermatomes in the midclavicular line, measured 21 h after first bolus injection.RESULTSFifty patients were randomly assigned to each group; finally, the data of 24 and 25 patients in Group C and P, respectively, were analysed. The mean difference in the number of desensitised dermatomes in the midclavicular line at 5 and 21 h after the initial bolus administration was 1.0 [95% confidence interval (CI) 0.5 to 1.5] and 1.6 (95% CI 1.1 to 2.0), respectively, which was significantly higher in Group P than in Group C (P < 0.001). The median difference in rescue morphine consumption in the early postoperative period (0 to 24 h) was 4 (95% CI 1 to 8) mg, which was significantly lower in Group P (P = 0.035). No significant difference in the postoperative numerical rating scale score was found between the groups.CONCLUSIONSPIB for erector spinae plane block in video-assisted thoracic surgery resulted in a larger anaesthetised area and required a lower anaesthetic dose to maintain the analgesic effect. Therefore, it is more suitable for erector spinae plane block than continuous infusion.TRIAL REGISTRATIONUMIN Clinical Trials Registry (UMIN-CTR, ID: UMIN000036574, Principal investigator: Taro Fujitani, 04/22/2019, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000041671).
Adolescent and young adult cancers: unmet needs and closing the gaps
Authors: Berkman Amy M. , Mittal Nupur , Roth Michael E. 
Published: January 2023

Purpose of review
There is a growing population of adolescent and young adult (AYA, ages 15–39 years) cancer patients and survivors, and the field of AYA oncology is rapidly evolving. Despite an increased focus on survival and quality of life for AYAs, gaps in knowledge remain. The current review focuses on what is known across several domains unique to AYA cancer care as well as areas of improvement and future directions in research and intervention.

Recent findings
Due to the developmental stages included in the AYA age range, a cancer diagnosis and treatment can affect relationships, education and employment, finances, and long-term health differently than diagnoses in younger or older populations. Recent studies that have focused on these unique aspects of AYA cancer care, including health-related quality of life (HRQoL), fertility, financial toxicity, barriers to clinical trial enrollment, genetic predisposition, and survivorship care are included in the current review.

Summary
Although studies have described many of the challenges faced by AYAs across the cancer continuum from diagnosis to survivorship, more work is needed, particularly in systematically measuring HRQoL, eliminating barriers to clinical trial enrollment, addressing financial toxicity, and increasing access to fertility preservation and high-quality survivorship care.
FDA regulatory considerations for the review of drugs intended to treat pediatric cancers and rare tumors
Authors: Bradford Diana , Singh Harpreet , Donoghue Martha 
Published: January 2023

Purpose of review
We describe select recent FDA approvals in pediatric cancers and rare tumors, and the unique regulatory considerations raised by each application.

Recent findings
The approvals of naxitamab, selumetinib, selpercatinib, and crizotinib for pediatric and adolescent patients between April 2020 and January 2021 all represented first FDA approvals in their respective pediatric or adolescent populations. In addition, all represent approvals of targeted therapies administered in select patient populations, and were based on overall response rate (ORR) and duration of response (DOR) data in single-arm trials.

Summary
Recent approvals for the pediatric oncology indications have often, but not always, relied in part upon investigator-sponsored clinical trials. Early engagement with regulatory agencies to discuss drug development in rare populations is critical to obtain early agreement on trial design and streamline development. Although reliance on ORR and DOR data may be feasible to support an approval, the ability to rely on response rate depends on many factors, including the disease context, reliability of radiographic assessment, and the results of the trial. In some cases, a time-to-event endpoint may be most appropriate to assess clinical benefit; early consideration should be given to the feasibility of conducting of a randomized trial.