bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Efficacy of Tadalafil and Tadalafil + Dapoxetine in Managing Sexual Dysfunction in Individuals with Type-2 Diabetes Mellitus
Authors: Chavda Vipul , Jha Santosh , Gandhi Tejal R. , Patel Anjali B. , Raninga Hiren , Chaudhari Amol , Hasnani Dhruvi 
Published: February 2023

Objective:
The present study was aimed to evaluate effect of metabolic parameters on erectile dysfunction (ED) in individuals with type-2 diabetes mellitus (T2DM) and to assess the efficacy of Tadalafil and Tadalafil + Dapoxetine combination.

Materials and Methods:
A prospective, observational, cross-sectional, bicentric study included 216 males with T2DM who are not treated with phosphodiesterase 5 inhibitors and without chronic kidney disease. The data were obtained from demographic questionnaire, clinical laboratory reports of glycometabolic parameters namely body mass index (BMI), hemoglobin A1c (HbA1c), testosterone, vitamin B12 (VitB12), and lipid profile and analyses of the International Index of Erectile Function (IIEF) questionnaire. The effect of physical and metabolic parameters on IIEF sub-domains namely erectile function; orgasmic function; sexual desire (SD); intercourse satisfaction; and overall satisfaction was evaluated. A statistical significance was evaluated using χ
2 test or t-test.

Result:
SD is most significantly lower in subjects with imbalanced physiological and metabolic characteristics including BMI, HbA1c, testosterone, VitB12, triglyceride, high-density lipoprotein, and low-density lipoprotein. Both Tadalafil and Tadalafil + Dapoxetine significantly improved almost all IIEF parameters without any pronounced effect of either. Similarly, both the treatments improved all the IIEF parameters for subjects with high BMI except for SD. In subjects with cardiac comorbidities, the use of either treatment significantly enhanced all the IIEF scores.

Conclusion:
The findings of this study outline the need of careful examination of sexual dysfunction in healthcare clinics for diabetic individuals. An imbalanced physiological and metabolic profile leads to ED in individuals with T2DM. Additionally, the presence of co-morbidities further elevates the odds of ED prevalence. The treatment with Tadalafil and Tadalafil + Dapoxetine drug combination shows promising results in improving the ED but a study with larger pool of subjects is needed to determine the additional benefits of Dapoxetine.
Development and Validation of a Situational Anxiety Scale Screening Assessment among Adults with Type 2 Diabetes During COVID-19 at a Tertiary Centre in Chennai, India
Authors: Poongothai Subramani , Latha Satish , Lalasa Mokkapati , Swetha Karthikeyan , Mohan Viswanathan 
Published: February 2023

Aim:
The aim of this study was to develop and validate the situational anxiety scale (SAS) during COVID-19 among adults with type 2 diabetes attending a tertiary diabetes center in Southern India.

Materials and Methods:
A total of 100 individuals aged from 18 to 65 years with type 2 diabetes attending a tertiary care diabetes center completed a structured SAS at two visits. The first visit (visit 1) survey was conducted in April 2021 and the second visit (visit 2) survey was conducted in March 2022. The SAS was administered to all 100 individuals. The State Trait Anxiety Inventory Scale (STAI-S) consisting of 20 questions was administered to the same 100 individuals in addition to the SAS during Visit 2.

Results:
The SAS showed good internal consistency for visit 1 (α = 0.855) and visit 2 (α = 0.795). Exploratory factor analysis showed four factors and explained 69% of variance. The four factors identified were as follows: (1) fear, (2) desire for COVID-free state, (3) lack of interest and energy, and (4) financial worries. A weak positive correlation was observed between SAS visit 2 and STAI-S, and it was statistically significant (r = 0.223; P = 0.026).

Conclusion:
The SAS is a valid and reliable tool for measuring situational anxiety during pandemics and post-COVID anxiety levels, which can help in the development of a holistic approach.
Effect of Gamma Irradiation on the 24-h Glycemic Responses of Parboiled Brown Rice Diets in Asian Indian Adults
Authors: Shobana Shanmugam , Gayathri Rajagopal , Jayanthan Mathiyazhagan , Sudha Vasudevan , Jamdar Sahayog N. , Malleshi Nagappa G. , Krishnaswamy Kamala , Mohan Anjana Ranjit , Unnikrishnan Ranjit , Mohan Viswanathan 
Published: February 2023

Background:
The nutritional importance of brown rice (BR) is well established. Despite several nutritional benefits of BR, its consumption remains limited due to long cooking time and limited shelf-life. BR can be subjected to processing to improve shelf-life. Gamma irradiation is one such strategy, but it could induce changes in the grain and thus affect its glycemic properties.

Aims and objectives:
The aim of this study was to look at the 24-h glycemic response of irradiated and non-irradiated BR-based iso-caloric diets in Asian Indians.

Methods:
Fifteen (mean body mass index: 24 ± 2.6 kg/m2) Asian Indian adults without diabetes, aged 25–39 years, participated in this randomized cross-over study. Iso-caloric diets were prepared with two varieties (ADT 43 and Swarna) of parboiled gamma-irradiated brown rice with 750–820 Gy dosage (IBR) and non-irradiated brown rice (NIBR). After the participants consumed these diets, 24-h glycemic responses were recorded using a continuous glucose monitoring system. The mean positive change from baseline glucose concentration was calculated as the incremental area under the curve (IAUC) for both the diets.

Results:
The percentage difference in 24-h average IAUC was 10% lower in the IBR diets when compared with NIBR diets, irrespective of the variety of BR (P = 0.56). In the case of ADT 43 rice variety, both IBR and NIBR diets showed similar IAUC (P = 0.68). However, the IBR of Swarna rice variety showed 21% lower IAUC when compared with the NIBR diet (P = 0.21). Comparing the IBR varieties, Swarna showed 21% lower IAUC than ADT 43 (P = 0.21), whereas between NIBR varieties, only 0.79% difference was observed between ADT 43 and Swarna (P = 0.93).

Conclusions:
Gamma irradiation of parboiled BR did not produce significant differences in the 24-h glycemic responses for BR-based diets. Swarna variety was better than ADT 43 with regard to glycemic response. Judicious application of radiation technology to BR varieties may help in shelf-life extension without affecting the glycemic properties.
Assessment of Serum Galectin-3 Levels in Patients with Gestational Diabetes Mellitus
Authors: Baldane Suleyman , Celik Murat , Korez Muslu K. , Gul Baldane Emine , Abusoglu Sedat , Ali Unlu , Ipekci Suleyman , Kebapcilar Levent 
Published: February 2023

Objective:
This study was aimed to compare serum galectin-3 (Gal-3) levels in gestational diabetes mellitus (GDM) and healthy pregnant women and to evaluate the relationship between insulin resistance parameters and serum Gal-3 levels.

Materials and Methods:
Fifty-nine pregnant women who were screened for GDM with oral glucose tolerance tests (OGTT) at the 24th–28th gestational weeks were included in the study. According to the results of OGTT, 34 pregnant women were included in the GDM group and 25 pregnant women were included in the control group.

Results:
Serum Gal-3 value was found to be similar in the GDM and control group (P < 0.471). However, there was a significant positive association between Gal-3 and fasting insulin (r = 0.509, P < 0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.479, P < 0.001) in the whole pregnancies, and between Gal-3 levels and fasting insulin (r = 0.608, P < 0.001), HOMA-IR (r = 0.609, P < 0.001), and OGTT 60 min glucose (r = 0.444, P = 0.016) in the GDM patients.

Conclusions:
There was no difference in the last trimester serum Gal-3 levels between GDM and healthy pregnant women. However, a significant positive correlation was determined between Gal-3 and fasting insulin, HOMA-IR, and OGTT 60 min glucose values in the GDM group, and fasting insulin and HOMA-IR values in whole pregnancies. The results of our study support previous data reporting the relationship between Gal-3 and GDM through insulin resistance.
Direct tracking of noncircular sources for multiple arrays via improved unscented particle filter method
Authors: Qian Yang , Shi Xinlei , Zeng Haowei , Ahmad Mushtaq 
Published: February 2023

AbstractDirect tracking problem of moving noncircular sources for multiple arrays is investigated in this study. Here, we propose an improved unscented particle filter (I‐UPF) direct tracking method, which combines system proportional symmetry unscented particle filter and Markov Chain Monte Carlo (MCMC) algorithm. Noncircular sources can extend the dimension of sources matrix, and the direct tracking accuracy is improved. This method uses multiple arrays to receive sources. Firstly, set up a direct tracking model through consecutive time and Doppler information. Subsequently, based on the improved unscented particle filter algorithm, the proposed tracking model is to improve the direct tracking accuracy and reduce computational complexity. Simulation results show that the proposed improved unscented particle filter algorithm for noncircular sources has enhanced tracking accuracy than Markov Chain Monte Carlo unscented particle filter algorithm, Markov Chain Monte Carlo extended Kalman particle filter, and two‐step tracking method.
The implementation of mobile learning for geometry and trigonometry students at CECyT 16 "Hidalgo"
Authors: Arroyo María Mónica García , Rivera Humberto Cuevas 
Published: February 2023

This paper presents the work of qualitative cut research as a result of the analysis of the implementation of Mobile Learning for students of the upper middle level in the Centrodef Estudios Científicos y Tecnológicos No. 16 Hidalgo, Mexico; being a support strategy for the teaching and learning process, where ICT is easy to transfer and viable, improving and speeding up its implementation; since having an Internet connection is having access to countless open resources and the barrier of distances do not exist. In the academic context, Internet revolutionized the way of presenting information, innovating the way in which it is learned and how it is taught, becoming playful, dynamic and fun; Currently, young people are used to new technologies, mobile devices such as cell phones and tablets used inside and outside the classroom, become a vital tool for mobile education taking advantage of the portability and ease of being able to connect anywhere and at any time.
Facilitating Independent and Collective Writing Skill Proficiency: The Think-Pair-Share Strategy Involvement
Authors: Akinwamide T. K. Ekiti , Oguntade F. M. 
Published: February 2023

Purpose: This study investigated the effects of Think-Pair-Share (TPS) strategy and the Conventional method on students’ performance and attitude to essay writing in senior secondary schools in Ondo State.
Methodology: The study adopted a quasi-experimental pre-test post-test two-group design as well as a descriptive survey-type design. The population for the study comprised all the public Senior Secondary School (SSS) III students of the 2021/2022 Session in Ondo State. The sample for this study was 65 SSS III students that were selected purposively. The two instruments used for this study are Essay Writing Attitudinal Scale and Students’ Socio-economic Background Status (EWASSSBS) and the Essay Writing Performance Test (EWPT). The reliability of EWPT was established through the test re-test method and a reliability coefficient of 0.70 was obtained while a reliability of EWASSSBS was obtained. The scores of the respondents from single administration were subjected to the Cronbach Alpha Reliability Co-efficient test and 0.82 was obtained.
Findings: The outcome revealed a substantial difference between the two groups Post-Treatment Performance Scores. The post-treatment performance means score for the TPS group was 15.67, whereas the post-performance mean score for the conventional group was 12.63. The results also showed that students who were taught essay writing utilising the TPS technique had a significantly different attitude.
Unique Contribution to Theory, Policy, and Practice: The study concluded that the TPS strategy enables student involvement in the learning process. The teachers encourage learning rather than being the exclusive source of knowledge for the students. Through collaborative learning, students have the chance to exchange ideas, respond, think creatively, discuss, critique, and assist their peers in creating better essays. As a result, we recommend that the government should ensure that English Language teachers are trained on how to use TPS strategies at regular intervals so that they can supplement the conventional method of teaching essay writing in Nigerian schools.
ANALISIS FAKTOR EKONOMI DAN NON EKONOMI YANG MEMPENGARUHI PERILAKU KONSUMEN INDOMARET (STUDI KASUS INDOMARET DESA RUMAH TIGA KOTA AMBON)
Authors: Manuhutu Stenly , Louhenapessy Desry Jonelda , Matitaputty Izaac Tonny 
Published: February 2023

The purpose of this research is: 1) To find out the influence of economic factors on the behavior of indomaret consumers in Rumah Tiga Village of Ambon City. 2) To find out the influence of non-economic factors on the behavior of indomaret consumers in Rumah Tiga Village of Ambon City 3) Provide references for student friends to find out the influence of Economic and Non-Economic Factors on Indomaret Consumer Behavior in Rumah Tiga Village of Ambon City to be developed in future research
The result of study show that economic (X1) and non economic (X2) variables have a significant influence on the Y variable (consumer behavior). This can be seen from the F test result, so F count > F table (20.441 > 3.16) or sig F < 5% (0.000< 0.05).
The economic factor that most influences the dependent variable is consumer behavior. This is based on the result of the t-test X1 where t count > t table (4.296 > 2.0024) or the significance of t < 5% (0.000< 0.05) then partially X1 variable (economic factor) has a significant influence on the Y variable (consumer behavior).
CHANGES IN ECONOMIC STRUCTURE AND THEIR EFFECT ON POVERTY IN MALUKU PROVINCE
Authors: Saptenno Fibryano , Effendi Janni , Assel Muh Ridhwan 
Published: February 2023

The indicators used to measure changes in economic structure and their effect on poverty are the Primary Sector Growth Factor (GR), Secondary Sector Growth (GS), and Tertiary Sector Growth (GT) are factors that affect Economic Structure Change (YR, YS, YT ), Per capita Income, and Poverty Level. So far, Maluku Province is still attached to a poor province.
This study aims to analyze changes in economic structure and their effect on poverty in Maluku Province for the 2009-2018 period. The data collection method in this study uses documentation techniques. While the data analysis technique to determine the economic structure uses Location Quetient (LQ) analysis and Shift Share analysis. Meanwhile, to measure the influence of the economic structure on the poverty level, it is carried out through a two-stage analysis. The first stage is to directly analyze the effect of the economic structure on the poverty level, then the second stage is to analyze the effect of the economic structure on the poverty level through the absorption of labor. The analytical technique used is Path Analytic technique.
Based on the results of the study (1) From the Shift Share analysis of the Gross Regional Domestic Product (GRDP) of Maluku Province in 2009-2018, it shows that the economic structure in Maluku Province is dominated by the primary sector, as seen from the total component of the Shift Share analysis of the nine sectors, there are The three sectors that contribute the most to GRDP are agriculture, construction, and services. While the results of the Shift Share analysis on the employment of Maluku Province in 2009-2018, the primary sector has a negative Shift Share component value of -31775 workers, which is slower to absorb labor than the same sector at the provincial level. The results of data analysis through Path Analysis show that (2) the economic structure contributes and has a significant effect on employment as much as 55%; (3) The economic structure contributes directly and has a significant effect on the poverty rate by 40%.
DAMPAK PERTUMBUHAN EKONOMI, INFLASI, DAN KURS TERHADAP FOREIGN DIRECT INVESTMENT (FDI) DI INDONESIA
Authors: Sangur Korneles , Liur Lisye Magdalena 
Published: February 2023

ABSTRACT
Research Method: Multiple regression model. The method of data collection carried out is the literature method. Results: The effect of GDP, inflation, and exchange rate, then obtained the value of f-count > f-table (16.24765> 3.01 ) with a significant value of 0.000025 < 0.05, the effect of GDP on FDI investment in Indonesia shows an insignificant value with a prob value of > of 0.05 (0.0647 > 0.05) and a t-count value < t-table ( 2,013 < 2,945), the effect of inflation on FDI investment in Indonesia shows a significant value with a prob value < of 0.05 (0.0005 < 0.05) and t-count value < t-table (3,517 > 2,945), the effect of the exchange rate value on FDI in Indonesia shows an insignificant value with a prob value > from 0.05 (0.0659 > 0.05) and and a t-count < t-table (2,016 < 2,945). Conclusion: Showing simultaneously independent variables affecting dependent variables is shown by the f-count value > F-table. Partially, the economic growth variable calculated using GDP in 2000-2019 is positive and has no significant effect on FDI investment in Indonesia; inflation as seen from inflation data for 2000-2019 has a positive and significant effect on FDI investment in Indonesia; the exchange rate seen from the middle rate from 2000-2019 is positive and has no significant effect on FDI investment in Indonesia.
Keywords : Economic Growth, Investment, Exchange Rate, Inflation
STUDI KOPIGMENTASI CAMPURAN EKSTRAK BIJI KESUMBA KELING (Bixa orellana L.) DENGAN EKSTRAK ANGKAK MERAH
Authors: Alfajar Said Haikal , Salman Salman , Zebua Nilsya Febrika , Sari Nurmala 
Published: February 2023

Pemakaian pewarna pada produk bertujuan untuk memperbaiki warna dan menarik minat konsumen. Penggunaan pewarna alami memiliki kelemahan antara lain warna tidak stabil dibandingkan dengan pewarna sintetis. Namun dibalik keunggulan zat warna sintetis menyimpan dampak berbahaya bagi kesehatan manusia seperti pencetus kanker. Karena dampak yang berbahaya bagi kesehatan, masyarakat lebih memilih pewarna alami dibandingkan pewarna sintetis. Salah satu pewarna alami yang baik bagi kesehatan manusia adalah biji kesumba keling dan angkak merah yang mengandung zat warna alami yaitu karotenoid dan antosianin. Tujuan dari penelitian ini untuk menganalisis zat warna yang stabil dari campuran biji kesumba keling dengan angkak merah dengan metode kopigmentasi. Dalam penelitian ini dilakukan proses maserasi untuk mendapatkan ekstrak dari biji kesumba keling dan angkak merah dengan perbandingan 1:10 (b/v). Lalu dicampurkan ekstrak kental dari biji kesumba keling dan angkak merah dengan perbandingan 1:0, 1:1, 1:2 dan 2:1 untuk dilakukan uji stabilitas terhadap pH, paparan sinar matahari, oksidator, penyimpanan, paparan sinar lampu dan suhu lalu diukur absorbansi dengan spektrofotometer visibel. Hasil penelitian menunjukan bahwa rendemen yang didapat dari maserasi biji kesumba keling dan angkak merah sebesar 8,65% dan 11,19%. Uji kestabilan 2:1 memiliki rata-rata kenaikan dan penurunan absorbansi sebesar 33,73%, 30,61% dan 15,06% pada uji pH, paparan sinar matahari dan paparan sinar lampu. Dari uji stabilitas didapatkan bahwa perbandingan 1:2 memiliki rata-rata kenaikan maupun penurunan absorbansi sebesar 2,24% dan 19,28% pada uji oksidator dan uji suhu. Dari uji stabilitas didapatkan bahwa perbandingan 1:1 memiliki rata-rata kenaikan maupun penurunan absorbansi sebesar 12,93% pada uji penyimpanan. Perbandingan 2:1 memiliki kestabilan yang paling baik dibandingkan dengan perbandingan yang lain.
Meningkatkan Pengetahuan Masyarakat Mengenai Kesehatan Menopause dan Pemberian Dukungan pada Lansia di Desa Cinta Rakyat Percut Sei Tuan
Authors: Erika Erika , Fridayana Fitri Rahma 
Published: February 2023

Lanjut usia (lansia) merupakan orang yang sudah memiliki perubahan tahap demi tahap pada kurun waktu tertentu, setiap orang yang sudah tua akan timbul masalah kesehatan bila tidak terjaga kesehatan dengan baik. Perubahan yang dialami lanjut usia yaitu perubahan fisik, kognitif, psikologis, biologis, ekonomi, dan juga peran sosialnya dalam masyarakat. Seiring bertambahnya usia, umumnya akan terjadi berbagai perubahan fisik. Tidak hanya rambut atau kulit saja yang berubah, banyak perubahan fisik terjadi pada lansia. Mulai dari tulang semakin rapuh, penglihatan yang buram, hingga jantung yang bekerja lebih keras. Di Desa Cinta Rakyat Kecamatan Percut Sei Tuan Kabupaten Deli Serdang, dijumpai beberapa lansia yang merasa kurang diperhatikan oleh keluarganya karena dianggap hanya menambah beban keluarga. Padahal dengan dukungan keluarga dan lingkungan sekitar dapat meningkatkan kesehatan fisik dan kualitas hidup lansia. Dalam situasi ini diperlukan peningkatan pengetahuan masyarakat tentang kesehatan manopause untuk dapat mendukung kualitas hidup para lansia. Ini adalah tugas penting untuk menekan angka kesakitan para lansia, dalam situasi ini meningkatkan pengetahuan masyarakat tentang kesehatan manopause lansia agar dapat memberi dukungan pada kesehatan mereka. Tujuan dari penulisan artikel ini adalah untuk menilai peningkatan pengetahuan masyarakat setelah dilakukan penyuluhan dengan metode didaktik dan sokratik. Penyuluhan dilakukan pada 26 orang di Desa Cinta rakyat untuk dipublikasikan di jurnal.