bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Formation of MXene-Oxidized Sono/Chemo-Dynamic Sonosensitizer/Nanocatalyst for Antibacteria and Bone-Tissue Regeneration
Authors: Yu Yang , Lu Qunshan , Sun Junyuan , Zhang Pengfei , Zeng Linran , Vasilev Krasimir , Zhao Yunpeng , Chen Yu , Liu Peilai 
Published: January 2023

Abstract
Prolonged and incurable bacterial infections in soft tissue and bone are currently causing large challenges in the clinic. Two-dimensional (2D) materials have been designed to address these issues, but materials with satisfying therapeutic effects are still needed. Herein, CaO2-loaded 2D titanium carbide nanosheets (CaO2-TiOx@Ti3C2, C-T@Ti3C2) were developed. Surprisingly, this nanosheet exhibited sonodynamic ability, in which CaO2 caused the in situ oxidation of Ti3C2 MXene to produce acoustic sensitiser TiO2 on its surface. In addition, this nanosheet displayed chemodynamic features, which promoted a Fenton reaction triggered by self-supplied H2O2. We detected that C-T@Ti3C2 nanosheets increased reactive oxygen species (ROS) production in response to sonodynamic therapy, which displayed an ideal antibacterial effect. Furthermore, these nanoreactors facilitated the deposition of Ca2+, which promoted osteogenic transformation and enhanced bone quality in osteomyelitis models. Herein, a wound healing model and prosthetic joint infection (PJI) model were established, and the C-T@Ti3C2 nanosheets played a protective role in these models. Taken together, the results indicated that the C-T@Ti3C2 nanosheets function as a multifunctional instrument with sonodynamic features, which might reveal information regarding the treatment of bacterial infections during wound healing.
A national survey on registered products, availability, prices, and affordability of 100 essential medicines in community pharmacies across Sri Lanka
Authors: Liyanage Chiranthi Kongala , Gunawardane Mekala , Kumaradasa Pamodee Panchalee , Ranasinghe Priyanga , Jayakody Ravindra Laal , Galappatthy Priyadarshani 
Published: January 2023

Abstract
Introduction: Availability of essential medicines that meet the expected quality standards, in appropriate dosage forms at affordable prices is a fundamental prerequisite to fulfill healthcare needs of given a population. This study assessed available products, prices and affordability of essential medicines (EM) in community pharmacies in Sri Lanka with comparison of registration status from the National Medicines Regulatory Authority(NMRA).
Methods: A cross-sectional island-wide survey of 80 pharmacies was conducted according to World Health Organization and Health Action International Manual (WHO/HAI). Hundred medicines were selected from the global core list(n=14), regional core list(n=16) and the Sri Lanka Essential Medicine List (SL-EML) (n=70) based on healthcare needs. Number of registered products in 2015 and 2021 were compared.
Findings: Average availability was 85.4%(±12.31) and availability was lowest in the Northern province (69.38±21.18%)(p=0.008). Availability between the state owned, franchise and privately owned pharmacies was not significantly different (p>0.05). 89.4% medicines were affordable except for amiodarone, hydroxychloroquine, sitagliptin, soluble insulin, isophane insulin, losartan, levodopa carbidopa combination, clonazepam and ceftriaxone. The median price ratio (MPR) of 33.7% of medicines was less than 1 and MPR of 37.1% originator brands (OB) was over 3. Median number of generic brands in the market was 8(range 2-44), 9 % of medicines had 20 or more products in the market and 72.7% medicines had more products available than the number registered in 2015. The average number of registered products were similar in 2015(8.27) and 2021(7.59) (p=0.15).
Conclusion: The overall availability of EMs in Sri Lanka was high in all categories of community pharmacies. Medicines were largely affordable and reasonably priced in 2015, although OBs were generally more expensive. Majority of medicines had more products in the market than the number of registered products.
Hydrological cycle amplification overwhelms warming-driven oxygen loss in subsurface Atlantic Ocean
Authors: Hogikyan Allison , Resplandy Laure , Liu Maofeng , Vecchi Gabriel 
Published: January 2023

Abstract
The global ocean is losing oxygen due to warming, which is expected to significantly increase production of nitrous oxide, a greenhouse gas, and decrease the habitat of many megafauna. In the subtropical Atlantic Ocean, however, there is an observed oxygen gain that cannot be accounted for by observed warming. We show that the amplification of the hydrological cycle, a response to climate change which results in a ‘salty-get-saltier, fresh-get-fresher’ sea surface salinity pattern, influences deoxygenation patterns in an Earth System Model, and can explain the observed oxygenation. In the Atlantic Ocean, this hydrological cycle amplification leads to enhanced ventilation and oxygenation of ‘salty-get-saltier’ subtropical water masses, while reducing ventilation and oxygen content in ‘fresh-get-fresher’ water masses formed at higher latitudes. The oxygenation of subtropical Atlantic waters is thus shown to be a regional consequence of climate change (through surface salinity changes) even as the global consequence of climate change (directly through warming) is deoxygenation.
Design guidelines for the SPICE parameters of waveform-selective metasurfaces varying with the incident pulse width at a constant oscillation frequency
Authors: Imai Shiori , Homma Haruki , Takimoto Kairi , Tanikawa Mizuki , Nakamura Jin , Kaneko Masaya , Osaki Yuya , Niitsu Kiichi , Yongzhi Cheng , Fathnan Ashif Aminulloh , Wakatsuchi Hiroki 
Published: January 2023

Abstract
In this study, we numerically demonstrate how the response of recently reported circuit-based metasurfaces is characterized by their circuit parameters. These metasurfaces, which include a set of four diodes as a full wave rectifier, are capable of sensing different waves even at the same frequency in response to the incident waveform, or more specifically the pulse width. This study reveals the relationship between the electromagnetic response of such waveform-selective metasurfaces and the SPICE parameters of the diodes used. First, we show that reducing a parasitic capacitive component of the diodes is important for realization of waveform-selective metasurfaces in a higher frequency regime. Second, we report that the operating power level is closely related to the saturation current and the breakdown voltage of the diodes. Moreover, the operating power range is found to be broadened by introducing an additional resistor into the inside of the diode bridge. Our study is expected to provide design guidelines for circuit-based waveform-selective metasurfaces to select/fabricate optimal diodes and enhance the waveform-selective performance at the target frequency and power level.
Dynamic elasticity modulus of weathered red sandstone soil subject to drying-wetting cycles
Authors: Deng Yunye 
Published: January 2023

Abstract

The drying-wetting cycles has a significant effect on the dynamic behavior of the weathered red sandstone soil. A series of the unconsolidated undrained dynamic triaxial tests were conducted on the weathered red sandstone soil samples under different numbers of drying-wetting cycles N, and the hysteresis curves and dynamic backbone curves were obtained under different confining pressures σ3. A hyperbolic model of dynamic backbone curve based on Hardin-Drnevich model was proposed, and the regression expressions between the parameters of the proposed model and N were presented. The relation between the maximum dynamic elasticity modulus Edmax and N, σ3 was analyzed based on the proposed hyperbolic model. The fitting equation of dynamic elasticity modulus Ed and dynamic stress σd was put forward, and the relation between dynamic elasticity modulus Ed and N was studied. The main conclusions from this work as follows: (1) Hardin-Drnevich model can well express the hyperbolic behaviors of dynamic backbone curves of the weathered red sandstone soil. The proposed hyperbolic model and the expressions of Edmax and Ed can well reflect the influences of the numbers of drying-wetting cycles and σ3 on Edmax and Ed respectively. (2) Edmax and Ed increase with the increase of σ3 under certain N; and decrease with N under a certain σ3. (3) Ed of the weathered red sandstone soil increases non-linearly with the increase of dynamic strain εd. The introduced factor β can quantitatively reflects the influences of N on Edmax .
Refractory Right Ventricular Myocarditis Induced by Immune Checkpoint Inhibitor despite Therapy Cessation and Immune Suppression
Authors: Mohammad Khan O , Fanous Hanna , Vakamudi Sneha , Liu Yan 
Published: January 2023

Abstract
Background: Immune checkpoint inhibitors (ICIs) are currently widely used for treatment of various types of cancers. ICI-induced myocarditis, though uncommon, accounts for high risk of major adverse cardiac events and mortality, which makes appropriate diagnosis important. We here present a unique, challenging case of ICI-induced, refractory and isolated right ventricular myocarditis.
Case Presentation: A 32-year-old female with breast cancer presented with new onset chest pain and dyspnea shortly after initiation of Pembrolizumab. Coronary angiography showed normal coronary arteries and a cardiac magnetic resonance (CMR) revealed myocarditis primarily involving the right ventricle with chamber dilation and severe dysfunction. ICI therapy was stopped, and high dose steroid therapy was initiated and symptoms resolved. However, three months after initial presentation, the patient was hospitalized for DKA and decompensated right heart failure, and a repeat cardiac MRI at that time showed recurrent, isolated right ventricular ventricular (RV) myocardial inflammation/edema without LV involvement. High dose steroid therapy was started again and at 6-month follow up, surveillance CMR continued to show persistent right-sided myocarditis, patient was eventually treated with Abatacept with resolution of HF symptoms, RV dysfunction and dilation at 9-month follow up.
Conclusions: We describe a unique case of isolated ICI-induced right ventricular myocarditis leading to right ventricular failure, that was refractory despite ICI therapy cessation and immune suppression by repeated high dose steroids. Co-stimulatory pathway modulation with Abatacept eventually lead to the normalization of RV function and dilation nine months after initial myocarditis onset.
Magnetically-activated 3D printable PLA/PCL/Fe 3 O 4 composites for magnetic induction heating generation
Authors: Galarreta-Rodriguez Itziar , Lopez-Ortega Alberto , Garayo Eneko , Beato-López Juan Jesús , Roca Paulo La , Sanchez-Alarcos Vicente , Recarte Vicente , Gómez-Polo Cristina , Pérez-Landazábal Jose Ignacio 
Published: January 2023

Abstract
Additive manufacturing technology has attracted the attention of industrial and technological sectors due to the versatility of the design and the easy manufacture of structural and functional elements based on composite materials. The embedding of magnetic nanoparticles in the polymeric matrix enables the development of an easy manufacturing process of low-cost magnetically-active novel polymeric composites. In this work, we report a series of magnetic composites prepared by solution casting method combining 5 to 60 wt.% of 50 - 100 nm commercial Fe3O4 nanoparticles, with a semi-crystalline, biocompatible and biodegradable polymeric blend made of polylactic acid (PLA) and polycaprolactone (PCL). The composites were extruded, obtaining 1.5 mm diameter continuous and flexible filaments for fused deposition modelling 3D printing. The chemical, magnetic and calorimetric properties of the obtained filaments were investigated by differential scanning calorimetry, thermogravimetric analysis, magnetometry, and scanning electron microscopy. Furthermore, taking advantage of the magnetic character of the filaments, their capability to generate heat under the application of low-frequency AC magnetic fields (magnetic induction heating) was analysed. The obtained results expose the versatility of these easy manufacturing and low-cost filaments, where selecting a desired composition, the heating capacity can be properly adjusted for those applications where magnetic induction plays a key role (i.e., magnetic hyperthermia, drug release, heterogeneous catalysis, water electrolysis, gas capture or materials synthesis).
Room-temperature spin injection from a ferromagnetic semiconductor
Authors: Goel Shobhit , Khang Nguyen Huynh Duy , Anh Le Duc , Hai Pham Nam , Tanaka Masaaki 
Published: January 2023

Abstract
Spin injection using ferromagnetic semiconductors at room temperature is a building block for the realization of spin-functional semiconductor devices. Nevertheless, this has been very challenging due to the lack of reliable room-temperature ferromagnetism in well-known group IV and III-V based semiconductors. Here, we demonstrate room-temperature spin injection by using spin pumping in a (Ga,Fe)Sb / BiSb heterostructure, where (Ga,Fe)Sb is a ferromagnetic semiconductor (FMS) with high Curie temperature (TC) and BiSb is a topological insulator (TI). Despite the very small magnetization of (Ga,Fe)Sb at room temperature (45 emu/cc), we detected spin injection from (Ga,Fe)Sb by utilizing the large inverse spin Hall effect (ISHE) in BiSb. Our study provides the first demonstration of spin injection at room temperature from a FMS.
Solving Large-scale Discrete Time–cost Trade-off Problem Using Hybrid Multi-verse Optimizer Model
Authors: Pham Vu Hong Son , Dang Nghiep Trinh Nguyen 
Published: January 2023

Abstract
Time–cost trade-off analysis is one of the most important aspects of construction project planning and control. The completion time of one project can be shortened by allocating additional resources to key activities; however, additional costs are required for accelerating the project completion time. Thanks to the critical path method (CPM), total project costs can be reduced by using inexpensive resources for minor activities without affecting the project schedule. However, this method is not sufficiently effective to solve large-scale time–cost trade-off problems. This study introduces a hybrid multi-verse optimizer model (hDMVO) combining the multi-verse optimizer (MVO) and the Sine Cosine algorithm (SCA) to address the discrete time–cost trade-off problem (DTCTP). Four benchmark test problems, including two medium-scale instances (63 activities) and two large-scale instances (630 activities) are used to evaluate the performance of hDMVO. The results indicate that hDMVO can provide solutions that are superior to previous algorithms in the time–cost optimization of large-scale and complicated projects.
New compartment model for COVID-19
Authors: Odagaki Takashi 
Published: January 2023

Abstract
Population is separated into five compartments for COVID-19; susceptible individuals (S), pre-symptomatic patients (P), asymptomatic patients (A), quarantined patients (Q) and recovered and/or dead patients (R). The time evolution of each compartment is described by a set of ordinary differential equations. Numerical solution to the set of differential equations shows that quarantining pre-symptomatic and asymptomatic patients is effective in controlling the pandemic. It is also shown that the ratio of non-symptomatic patients to the daily confirmed new cases can be as large as 20 and that the fraction of untraceable cases in new cases can be as large as 80%, depending on the policies for social distancing and PCR test.
Hydropower dam alters the microbial structure of fish gut in different habitats in upstream and downstream rivers
Authors: Li Yusen , Zhou Kangqi , Zhao Huihong , Shi Jun , Wu Weijun , He Anyou , Han Yaoquan , Lei Jianjun , Lin Yong , Pan Xianhui , Wang Dapeng 
Published: January 2023

Abstract
Hydropower dams are an important green renewable energy technology, but their effect on the gut microbes of fish in different habitats surrounding the dams is unclear. We collected the gut of seven fish species (n = 109 fish) both upstream and downstream of a dam in Xijiang River basin, China, and identified the microbes present by 16s rRNA pyrosequencing. A total of 9,071 OTUs were identified from 1,576,253 high-quality tags with 97% sequence similarity. Our results indicated that the gut microbial diversity of upstream fish was significantly higher than that of downstream fish, though the dominant microbial species were similar and mainly comprised Proteobacteria (mean 35.0%), Firmicutes (20.4%) and Actinobacteria (15.6%). The presence of the dam markedly altered the gut microbial composition in Squaliobarbus curriculusand Hypostomus plecostomus. Moreover, we found specificity in the composition of gut microorganisms in fishes of different diets and pelagic levels, whereas the omnivorous Pseudohemiculter dispar had a higher level of species richness and diversity of gut bacteria compared with the other species. The results of the functional analysis showed that the abundance of microorganisms related to energy metabolism (e.g., amino acid metabolism, carbohydrate metabolism, biosynthesis metabolism) was significantly higher in the gut of upstream fish than in downstream fish. Our results showed that the hydropower station affected downstream levels of chlorophyll-a, total nitrogen and total organic carbon. Canonical correspondence analysis showed that water temperature, Hg and chlorophyll-a significantly affected gut microbial composition. These results are important for assessing the impact of hydropower plant on fish gut microbes and their potential environmental risks.
Uniform magnetic field impact on absolute versus convective onset of Darcy-Benard convection with horizontal throughflow
Authors: Turkyilmazoglu Mustafa 
Published: January 2023

Abstract
The onset of Darcy-Benard convection in a fluid-saturated porous layer within a channelled walls can be through either the convectively amplified perturbations or absolutely unstable modes. The convective type route to formation of cellular forms has received much more interest in the literature than the absolute mode. The present effort is to explore the absolute instability mechanism on triggering the Benard convection in the presence of a uniformly acting magnetic field perpendicular to the channel walls. Pursuing a completely theoretical linear stability approach, the locus of wavenumbers and critical Rayleigh numbers with respect to Peclet number leading to zero complex group velocity, and hence the absolute instability onset, is formulated in closed-form. The formulae also incorporate the influence of fluid movement through the porous layer. Wanenumbers are found to be increasing under the effect of the magnetic field. Although the magnetic field expectedly behaves in favor of stabilizing the convection * through both convective and absolute instabilities by pushing the threshold value of Rayleigh number to higher values, a peculiarity exists in such a manner that the stabilizing effect of magnetic field can no longer compete against the absolute instability mechanism within the magnetized field after some critical location of negative part of the wavenumber. This is attributed to the exchange of instabilities as far as the absolute instability mechanism is concerned. Magnetic field is always stabilizing and no such trend is observed regarding the convective type instability.
Lymph node stain after radical resection of rectal cancer mainly increased the harvest of mini lymph node: a randomized controlled trial
Authors: Xiao Jianlin , Zhang Hao , Jiang Dan , Deng Xiangbing , Wang Ziqiang 
Published: January 2023

Abstract
Aim: The lymph node status plays an important role in rectal cancer, which depends on adequate lymph node harvest. Lymph node stain techniques increase the lymph node harvest. The aim of this prospective study is to investigate which subgroups of lymph nodes harvested were increased mostly.
Methods: From May 2020 to May 2022, 172 stage II-III rectal cancer patients were randomized to methylene blue (MB) stained group or unstained group to retrieve the lymph nodes. Methylene blue solution was injected into the inferior mesenteric artery, we dissected lymph nodes by palpation and sight. The lymph nodes were divided into 3 groups depending on the anatomy (main lymph nodes, superior rectal and perirectal lymph nodes (SPLNs), and pericolic lymph nodes located beyond 10 cm proximal to the tumor), and 3 groups depending on the short diameter of the nodes (big: ≥5mm, small: 5mm~2mm, mini: ≤2mm).
Results:The number of lymph nodes harvested with MB was significantly higher (22.0(14.8,32.0) vs 14.5 (11.0,22.0); p <0.001) without difference in positive patients or number of positive nodes. The positive rate of the big node was 3.5%, the small node was 1.9%, and the mini node was 0.2%. In the subgroup analysis, the median number of mini lymph nodes in the MB-stained group was significantly more than unstained group (median (IQR): 9.0(6.0,14.0) vs 4.0(2.0,6.0), p<0.001); and the median number of SPLNs in the MB-stained group were significantly more than unstained group (median (IQR): 15.0(9.0,19.0) vs 10.0(6.0,13.3), p<0.001); these differences were existing in both patients with and without neoadjuvant treatments.
Conclusion:Intra-arterial injection of MB can significantly increase the number of lymph nodes harvested in rectal cancers, especially those mini lymph nodes. However, methylene blue staining did not significantly increase the number of positive lymph nodes and the proportion of patients with more than 12 lymph nodes, or affect lymph node staging accuracy after radical resection of rectal cancer
Pulse Pressure: A Predictor of Intervention in Blunt Abdominal Trauma
Authors: Salman Sumbla , Laeeque Osama , Jawaid Bushra , Jamil Omer Bin Khalid , Shahab Hassan , Faheem Komal 
Published: January 2023

Abstract
Background: Patients with life-threatening hemorrhage due to blunt torso trauma are at a particularly high risk of being under-diagnosed. The pulse pressure starts narrowing down before the traditional parameters start changing, making it a useful tool for assessing and planning early intervention.
Objective: Toassess the utility of low pulse pressure in predicting massive transfusion or operative intervention in patients with isolated blunt torso trauma.
Material and Methods: total of 186 patients were included. The pulse pressure and mean arterial pressure were calculated. Vitals, pulse pressure, and mean arterial pressure were monitored every 15 min during the first 6 h, then every 30 min during the next 6 h and afterwards, every 4 h until discharge. Chi-square test and an independent t-test (as appropriate) were applied to compare variables with pulse pressure at the time of presentation. A Differences were considered as statistically significant at p-value ≤ 0.05.
Results: total of 55.9% of these patients had injuries due to road traffic accidents. Emergency operative intervention was provided to 26.3% of the patients. Death was 4.3%. Massive transfusion was required by 26.3% of the patients. There was a statistically significant association between low pulse pressure and sex, length of stay, repeat eFAST, emergency operational intervention, outcome, massive transfusion, number of crystalloids consumed within the first four hours after presentation, injury severity score, systolic blood pressure, and pulse rate.
Conclusion: The pulse pressure <30 mmHg was observed as an independent predictor for increased blood loss requiring blood transfusion or operative intervention.