bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3‐WG1A General Pharmacology Working Group of the ILAE/AES Joint Translational Task Force
Authors: Coles Lisa , Forcelli Patrick A. , Leclercq Karine , Katsarou Anna‐Maria , Klein Brian D. , Potschka Heidrun , Koehling Rudiger , Harte‐Hargrove Lauren , Galanopoulou Aristea S. , Metcalf Cameron S. 
Published: March 2023

AbstractGrowing concerns over rigor and reproducibility of preclinical studies, including consistency across laboratories and translation to clinical populations, have triggered efforts to harmonize methodologies. This includes the first set of preclinical common data elements (CDEs) for epilepsy research studies, as well as Case Report Forms (CRFs) for widespread use in epilepsy research. The General Pharmacology Working Group of the ILAE/AES Task Force (TASK3‐WG1A) has continued in this effort by adapting and refining CDEs/CRFs to address specific study design areas as they relate to preclinical drug screening: general pharmacology, pharmacokinetics (PK) and pharmacodynamics (PD), and tolerability. This work has expanded general pharmacology studies to include dose records, PK/PD, tolerability, and elements of rigor and reproducibility. Tolerability testing CRFs included rotarod and Irwin/Functional Observation Battery (FOB) assays. The material provided in the form of CRFs can be delivered for widespread use within the epilepsy research community.
Frequency‐Sensitivity of the seismic damage to suspended ceilings
Authors: Feng Yunxing , Li Qiqi , Qu Zhe 
Published: March 2023

AbstractSeismic damage to suspended ceilings was frequently reported even in minor to moderate earthquakes and caused problems to immediate occupancy and quick recovery of buildings. While peak floor acceleration (PFA) has been exclusively used as an intensity measure for suspended ceilings, this study introduces a shake table test on minimum subassemblies of suspended ceilings under sinusoidal excitation to critically assess the rationality of this practice. The test results show a significant frequency‐sensitivity of the ceiling damage that, depending on the dominant frequencies, an excitation of a lower PFA might cause much severer damage than that of a higher PFA. A numerical model that captures the nonlinear interaction of the individual components in a suspended ceiling, that is, the main and cross runners, ceiling panels, a hanger, and enclosure angles, is established and calibrated to simulate the frequency‐sensitive behavior observed in the shake table tests. The model is then extended for suspended ceilings of realistic dimensions. Three‐dimensional fragility spectra of suspended ceilings under sinusoidal excitations are proposed to relate the extent of seismic damage with not only the PFA but also the excitation frequency. Boundaries of damage limit states can be defined by taking two‐dimensional sections on the fragility spectra, based on which, the influence of key factors on ceiling damage characteristics is illustrated.
Cytogenotoxicity Screening of Urban and Rural Marshes: An Integrated In Vivo Approach Coupling Fish and Plant-Based Tests Adapted for Low-Income Countries
Authors: Pepey Elodie , Conéjéro Geneviève , Ndrianaivo Elia Njara , Verdeil Jean-Luc , Mortillaro Jean-Michel , Boggio David , Raliniaina Modestine , Pouil Simon 
Published: March 2023

Abstract
Effects of anthropogenic activities such as urbanization, population growth, and agriculture on water quality are major concerns particularly in low-income countries where water quality monitoring can be challenging. The purpose of the present study was to evaluate the cytogenotoxic potential of water from urban and rural Malagasy marshes, coupling a fish (Nile tilapia, Oreochromis niloticus) and a plant (Allium cepa) species as bioindicators. The fish and plants were exposed for 72 h to water sampled in the two locations investigated. Using the comet assay on fish erythrocytes, DNA strand breaks were assessed, while mitotic index and nucleolar alterations were estimated in cells of the plant root apex. Comet assays revealed significant DNA strand breaks to fish erythrocytes in both the marshes investigated while the mitotic index and nucleolar characteristics in the roots of A. cepa mainly highlighted potential cytotoxicity in the urban marsh. Our results demonstrate the advantages of coupling in vivo biological test systems to screen potential cytogenotoxicity of surface water in low-income countries where comprehensive data sets of aquatic contaminants are often lacking. Environ Toxicol Chem 2023;42:1266–1275. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
International approaches to contamination management: Introduction to the RemTech Europe 2021 Special Series
Authors: Falconi Marco , Grenni Paola 
Published: March 2023

Abstract
Soil is a nonrenewable resource, and groundwater is a critical source of drinking water. Effective soil and water protection, assessment and, if affected, recovery from contamination are priorities around the world; eco-friendly interventions in line with the United Nations Sustainable Development Goals are favored objectives. These issues were discussed during the sixth RemTech Europe conference (https://www.remtechexpo.com/it/remtech-europe/remtech-europe), which focused on sustainable technologies for land and water remediation; environmental protection; and the rehabilitation, regeneration, and sustainable development of contaminated sites, encouraging diverse stakeholders to share cutting-edge technologies, case studies, and innovation. Effective, practical, and sustainable management of remediation is only possible if the projects are completed, which is supported when the participants start the remediation planning with this end in mind. Several strategies to support and achieve the finalization of sustainable remediation processes were discussed at the conference. Addressing these gaps were among the goals of the papers included in this special series, which were selected from the RemTech EU conference presentations. The papers include risk management plan case studies, bioremediation tools, and preventive measures for minimizing disaster impacts. Moreover, the use of common and shared international best practices for effective and sustainable contaminated site management, with policy alignment among the remediation stakeholders in different countries, was also reported. Finally, many regulatory gaps, for example, the lack of practical end-of-waste criteria for contaminated soils, were also discussed. Integr Environ Assess Manag 2023;19:910–912. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Pain in desmoid‐type fibromatosis: Prevalence, determinants and prognosis value
Authors: Penel Nicolas , Bonvalot Sylvie , Le Deley Marie‐Cécile , Italiano Antoine , Tlemsani Camille , Pannier Diane , Leguillette Clémence , Kurtz Jean‐Emmanuel , Toulmonde Maud , Thery Julien , Orbach Daniel , Dubray‐Longeras Pascale , Verret Benjamin , Bertucci François , Guillemet Cécile , Laroche Lucie , Dufresne Armelle , Blay Jean‐Yves , Le Cesne Axel 
Published: March 2023

AbstractThe aim of this study is to evaluate the prevalence, determinants and prognostic value of pain at diagnosis in patients with desmoid‐type fibromatosis (DF). We selected patients from the ALTITUDES cohort (NCT02867033), managed by surgery, active surveillance or systemic treatments, with pain assessment at diagnosis. Patients were invited to fill QLQ‐C30 questionnaire and Hospital Anxiety Depression Scale. Determinants were identified using logistic models. Prognostic value on event‐free survival (EFS) was evaluated using the Cox model. Overall, 382 patients were included in the current study (median age: 40.2 years; 117 men). The prevalence of pain was 36%, without significant difference according to first‐line treatment (P = .18). In the multivariate analysis, pain was significantly associated with tumor size >50 mm (P = .013) and tumor site (P < .001); pain was more frequent in the neck and shoulder locations (odds ratio: 3.05 [1.27‐7.29]). Pain at baseline was significantly associated with poor quality of life (P < .001), depression (P = .02), lower performance status (P = .03) and functional impairment (P = .001); we also observed a nonsignificant association with anxiety (P = .10). In the univariate analysis, baseline pain was associated with poor EFS; the 3‐year EFS was 54% in patients with pain compared to 72% in those without pain. After adjustment for sex, age, size and line of treatment, pain was still associated with poor EFS (hazard ratio: 1.82 [1.23‐2.68], P = .003). One third of recently diagnosed patients with DF experienced pain, especially those with larger tumors and neck/shoulder locations. Pain was associated with unfavorable EFS after adjustment for the confounders.
Alkaline earth metals for osteogenic scaffolds: From mechanisms to applications
Authors: Weng Yihang , Jian Yujia , Huang Wenlong , Xie Zhuojun , Zhou Ying , Pei Xibo 
Published: March 2023

AbstractRegeneration of bone defects is a significant challenge today. As alternative approaches to the autologous bone, scaffold materials have remarkable features in treating bone defects; however, the various properties of current scaffold materials still fall short of expectations. Due to the osteogenic capability of alkaline earth metals, their application in scaffold materials has become an effective approach to improving their properties. Furthermore, numerous studies have shown that combining alkaline earth metals leads to better osteogenic properties than applying them alone. In this review, the physicochemical and physiological characteristics of alkaline earth metals are introduced, mainly focusing on their mechanisms and applications in osteogenesis, especially magnesium (Mg), calcium (Ca), strontium (Sr), and barium (Ba). Furthermore, this review highlights the possible cross‐talk between pathways when alkaline earth metals are combined. Finally, some of the current drawbacks of scaffold materials are enumerated, such as the high corrosion rate of Mg scaffolds and defects in the mechanical properties of Ca scaffolds. Moreover, a brief perspective is also provided regarding future directions in this field. It is worth exploring that whether the levels of alkaline earth metals in newly regenerated bone differs from those in normal bone. The ideal ratio of each element in the bone tissue engineering scaffolds or the optimal concentration of each elemental ion in the created osteogenic environment still needs further exploration. The review not only summarizes the research developments in osteogenesis but also offers a direction for developing new scaffold materials.
The intersection of adverse childhood experiences and mental health concerns for youth involved in the child welfare system
Authors: Vieira Alyssa , Sheerin Kaitlin M. , Modrowski Crosby , Kemp Kathleen 
Published: March 2023

AbstractThe present study sought to identify if there is distinct mental health symptomology among child welfare‐involved youth depending on the category of adverse childhood experiences (ACEs) endorsed. A chart review of child welfare‐involved youth (N = 129, ages 8–16) and caregiver reported ACEs and mental health/trauma symptoms was conducted. A K‐means cluster analysis used ACE scores to identify groups of youth along two dimensions: household dysfunction and child abuse/neglect. The first cluster identified had low ACE scores outside of their system involvement (n = 62), the second predominantly endorsed household dysfunctions (n = 37), and the third predominantly endorsed abuse/neglect (n = 30). One‐way analysis of variance tests revealed that youth in the systems‐only cluster differed from youth in the other groups, while the two high ACE category groups did not differ from each other on mental health/trauma symptoms. These results have important implications for the screening and treatment referral processes in the child welfare system.
The Impact of Sedative Hypnotic Drugs on Hallucinated Sexual Assault or Sexual Fantasies Involving Health Professionals: A Systematic Review
Authors: White Melody , White C. Michael 
Published: March 2023

AbstractThis article discusses the rare but serious occurrence of sedative hypnotic drug–induced sexual thoughts. We searched PubMed from the earliest date to February 7, 2023. Articles were selected if they provided data on sexual assault hallucinations or sexual fantasies associated with the use of sedative hypnotic drugs including benzodiazepines, propofol, nitric oxide, ether, chloroform, ketamine, or esketamine. Twenty‐two citations provided useful information, including 87 cases of hallucinations about sexual assault or sexual fantasy. In several of the cases, the environment and monitoring made the actual occurrence of sexual assault unlikely, but there was still significant anguish for the patients and the accused clinicians. In many of the cases, the places of the body where procedures were conducted coincided with the area of the body where the patients perceived the sexual assault or fantasy occurred. The higher the dose of sedative hypnotic administered, the greater the risk of experiencing a hallucination about sexual assault or sexual fantasy. The US Food and Drug Administration Adverse Events Reporting System has numerous occurrences in which “excessive sexual fantasies” and “abnormal dreams” were associated with the use of sedative hypnotic medication but also occurrences of “sexual abuse.” While sexual assault hallucinations or fantasies associated with sedative hypnotics are rare, it is imperative that health care providers take the necessary precautions and follow recommendations to provide safety for themselves and their patients.
Remedies for the housewife's nervousness: Life advice in Abraham Myerson's popular self‐help texts, 1920–1930
Authors: McLaughlin Matthew J. 
Published: March 2023

AbstractIn 1920, the psychiatrist Abraham Myerson published a self‐help book titled The Nervous Housewife. In his book, he argued that the living conditions in urban‐industrial America were responsible for a significant increase in the number of housewives who suffered from nervous symptoms. He also warned that women were consequently becoming increasingly discontent with the role and were beginning to desire a life outside motherhood and housewifery. Accordingly, The Nervous Housewife offered housewives and their husbands directions on how to improve her living conditions. This would allow readers to manage and prevent the emergence of nervous symptoms so that women would continue to desire a life as housewife and mother. Throughout the 1920s, Myerson would continue to publish health advice for housewives on how they could manage and eliminate their nervous symptoms. This article analyzes how Myerson connected the everyday experiences and conditions of the housewife's life to her nervousness in his texts and reveals how his motivation was to keep women satisfied with what he deemed was their proper societal role, that of housewife and mother. In doing so, it will also compare his work to other self‐help texts on nervousness to illuminate how his how‐to guide was innovative, while examining both scholarly and popular reviews of his book to reveal what his peers and readers perceived as the benefits of his advice.
Using Raman spectroscopy to detect scytonemin of epiliths and endoliths from marble, serpentinite and gypsum
Authors: Jehlička Jan , Culka Adam , Němečková Kateřina , Mareš Jan 
Published: March 2023

AbstractHere, we present Raman spectra showing the presence and distribution of scytonemin and carotenoids in epilithic and endolithic colonisations from temperate locations in Central Europe and Sicily. In the Bohemian Massif, marble and serpentinitic cyanobacterial epiliths dominated by cyanobacteria Scytonema, Stigonema, Hassallia, Gloeocapsopsis and Gloeocapsa were investigated using light microscopy and Raman spectroscopy. Scytonemin was a common dark pigment, accompanied by carotenoids and gloeocapsin on the marbles from Opolenec and on serpentinites from Holubov (South Bohemia). Raman spectra from other sites originated from endolithic colonisations of gypsum. They were located in the Carpathian foredeep (Badenian, Silesian unit, eastern Poland) and in Messinian complexes in the Mediterranean area (Sicily). Similarly to the previous localities, almost ubiquitous occurrence of scytonemin confirmed the presence of cyanobacterial colonisations. Obtained findings are important from the spectroscopic point of view. Additionally, comparing results from several sites confirmed the common occurrence of scytonemin in both endoliths and epiliths from areas that cannot be considered climatically extreme, although they experience rapid fluctuations in temperature, humidity and UV irradiation on the exposed rocky substrates.
Effects of different protectants on the IgY content and physico‐chemical properties of spray‐dried egg yolk powder
Authors: Ang Yuan , Cao Weiwei , Wang Zhe , Li Linlin , Zhao Mengyue , Liu Zhiqin , Jin Xin , Jin Jiuyu , Dong Jingyin , Zhang Yan , Bhandari Bhesh , Ren Guangyue , Duan Xu 
Published: March 2023

AbstractBackgroundEgg yolk powder (EYP) with high immunoglobulin of yolk (IgY) content and good solubility is in great demand in the market of functional foods. In this article, the properties of spray‐dried EYP with the addition of five protectants (maltodextrin, trehalose, mannitol, maltitol and sucrose) were investigated.ResultsAll the protectants increased IgY activity and solubility of EYP. Among them, EYP with maltodextrin displayed the highest activity of IgY (27.11 mg/g), the highest solubility (66.39%) and the lowest surface hydrophobicity. Moreover, the average particle size of EYP with maltodextrin was the smallest (9.78 μm). The egg yolk particles obtained by adding the protectants are more uniformly distributed and have smaller particle size. Fourier‐transform infrared spectroscopy confirmed the structural integrity of the proteins, indicating that the protectants addition enhanced the hydrogen bonding forces between the EYP protein molecules.ConclusionThe addition of protectants can significantly improve the IgY content, solubility and structural stability of EYP. © 2023 Society of Chemical Industry.
Patient and caregiver experience with telehealth for surgical cancer care: A qualitative study
Authors: Nguyen Oliver T. , Mason Arianna , Khanna Neel , Charles Dannelle , Naso Cristina , Hong Young‐Rock , Sprow Olivia , Alishahi Tabriz Amir , Turner Kea , Spiess Philippe , Patel Krupal B. 
Published: March 2023

AbstractIntroductionThe COVID‐19 pandemic led to telemedicine adoption for many medical specialties, including surgical cancer care. To date, the evidence for patient experience of telemedicine among patients with cancer undergoing surgery is limited to quantitative surveys. Thus, this study qualitatively assessed the patient and caregiver experience of telehealth visits for surgical cancer care.MethodsWe conducted semistructured interviews with 25 patients with cancer and three caregivers who had completed a telehealth visit for preanesthesia or postoperative visits. Interviews covered visit descriptions, overall satisfaction, system experience, visit quality, what roles caregivers had, and thoughts on what types of surgery‐related visits would be appropriate through telehealth versus in‐person.ResultsTelehealth delivery for surgical cancer care was generally viewed positively. Multiple factors influenced the patient experience, including prior experience with telemedicine, ease of scheduling visits, smooth connection experiences, having access to technical support, high communication quality, and visit thoroughness. Participants identified use cases on telehealth for surgical cancer care, including postoperative visits for uncomplicated surgical procedures and educational visits.ConclusionsPatient experiences with telehealth for surgical care are influenced by smooth system experiences, high‐quality patient‐clinician communications, and a patient‐centered focus. Interventions are needed to optimize telehealth delivery (e.g., improve telemedicine platform usability).
Reflectance confocal microscopic visualization of melanocytic bodies in the stratum corneum overlying acral lentiginous melanoma
Authors: Natarelli Nicole , Hanlon Katharine , Chen Wei‐Shen , Grichnik James M. , Zager Jonathan S. , Correa‐Selm Lilia 
Published: March 2023

AbstractBackgroundWe present a case of RCM evaluation of ALM surgical margins demonstrating intracorneal melanocytic bodies overlying subsequently confirmed melanoma in situ by histopathology.Case PresentationA 73‐year‐old male with a history of acral lentiginous melanoma (ALM) of the right great toe presented to our clinic for evaluation of positive surgical margins. The positive margin was localized for examination and subsequent biopsy with reflectance confocal microscopy (RCM) which allowed targeted re‐resection of the area of concern. Three punch biopsies were obtained in the area of concern, which confirmed residual melanoma in situ. Immunostains confirmed the cellular remnants in the stratum corneum were melanocytic. To correlate the intra stratum corneum findings seen with confocal to the histopathology, a 3D rendering of a stack of images was used to demonstrate the location.DiscussionTypically, acral surfaces are challenging to examine with RCM due to the limited ability of light to penetrate thickened stratum corneum; however, we observed unique cellular features with confocal. Scattered hyper‐reflective pleomorphic cells consistent with melanocytes were observed in the stratum corneum, although the visualized underlying epidermis appeared normal. Confocal microscopy may aid in diagnosis and management of ALM, especially in the context of positive surgical margins.