bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of COVID‐19 on percutaneous coronary intervention utilization and mortality in New York
Authors: Hannan Edward L. , Zhong Ye , Cozzens Kimberly , Osinaga Alda , Efferen Linda , Jacobs Alice K. , Ling Frederick S. K. , Gary Walford , Venditti Ferdinand J. , Berger Peter B. , Tamis‐Holland Jacqueline , King Spencer B. 
Published: April 2023

AbstractBackgroundCOVID‐19 has disrupted the care of all patients, and little is known about its impact on the utilization and short‐term mortality of percutaneous coronary intervention (PCI) patients, particularly nonemergency patients.MethodsNew York State's PCI registry was used to study the utilization of PCI and the presence of COVID‐19 in four patient subgroups ranging in severity from ST‐elevation myocardial infarction (STEMI) to elective patients before (December 01, 2018–February 29, 2020) and during the COVID‐19 era (March 01, 2020–May 31, 2021), as well as to examine the impact of different COVID severity levels on the mortality of different types of PCI patients.ResultsDecreases in the mean quarterly PCI volume from the prepandemic period to the first quarter of the pandemic ranged from 20% for STEMI patients to 61% for elective patients, with the other two subgroups having decreases in between these values. PCI quarterly volume rebounds from the prepandemic period to the second quarter of 2021 were in excess of 90% for all patient subgroups, and 99.7% for elective patients. Existing COVID‐19 was rare among PCI patients, ranging from 1.74% for STEMI patients to 3.66% for elective patients. PCI patients with COVID‐19 and acute respiratory distress syndrome (ARDS) who were not intubated, and PCI patients with COVID‐19 and ARDS who were either intubated or were not intubated because of Do Not Resuscitate//Do Not Intubate status had higher risk‐adjusted mortality ([adjusted ORs = 10.81 [4.39, 26.63] and 24.53 [12.06, 49.88], respectively]) than patients who never had COVID‐19.ConclusionsThere were large decreases in the utilization of PCI during COVID‐19, with the percentage of decrease being highly sensitive to patient acuity. By the second quarter of 2021, prepandemic volumes were nearly restored for all patient subgroups. Very few PCI patients had current COVID‐19 throughout the pandemic period, but the number of PCI patients with a COVID‐19 history increased steadily during the pandemic. PCI patients with COVID‐19 accompanied by ARDS were at much higher risk of short‐term mortality than patients who never had COVID‐19. COVID‐19 without ARDS and history of COVID‐19 were not associated with higher mortality for PCI patients as of the second quarter of 2021.
Excited State Processes in Supramolecular Complexes of Cyclic Dibenzopyrrolopyrrole Isomers with C60 Fullerene
Authors: George Gibu , Stasyuk Olga. A. , Voityuk Alexander A. , Stasyuk Anton J. , Solà Miquel 
Published: April 2023

AbstractAn approach to modulating the properties of carbon nanorings by incorporating pyrrolo[3,2‐b]pyrrole units is of particular interest due to the combined effect of heteroatom and antiaromatic character on electronic properties. The inclusion of units other than phenylene leads to the formation of stereoisomers. In this work, we computationally study how the spatial orientation of monomeric units in the ring affects the properties of cyclic dibenzopyrrolo[3,2‐b]pyrroles and their complexes with C60 fullerene. For [4]PP and [4]DHPP, the most symmetrical AAAA isomer is the most stable and forms stronger interactions with fullerene than the isomers where one or two monomeric units are flipped, mostly due to less Pauli repulsion. π‐Electron delocalization in the monomeric unit is crucial for directing the electron transfer (from or to nanoring). The energy of excited states with charge transfer depends on the HOMO–LUMO gap, which varies from one stereoisomer to another only for [4]DHPP⊃C60 with aromatic 1,4‐dihydropyrrolo[3,2‐b]pyrrole units. The rates of electron transfer and charge recombination reactions are relatively weakly dependent of the spatial isomerism of nanorings.
Associations between household income and disordered eating differ across sex and racial identity in a population‐based sample of adults
Authors: Mikhail Megan E. , Ackerman Lindsay S. , Anaya Carolina , Culbert Kristen M. , Burt S. Alexandra , Klump Kelly L. 
Published: April 2023

AbstractBackgroundMost research on socioeconomic status (SES) and eating disorders (EDs) has focused on young White women. Consequently, little is known regarding how SES may relate to EDs/disordered eating in older adults, men, or people with different racial identities. We examined whether associations between SES and EDs/disordered eating differed across age, sex, and racial identity in a large, population‐based sample spanning early‐to‐later adulthood.MethodsAnalyses included 2797 women and 2781 men ages 18–65 (Mage = 37.41, SD = 7.38) from the population‐based Michigan State University Twin Registry. We first examined associations between SES and dimensional ED symptoms, binge eating (BE), and self‐reported ED diagnoses across age and sex in the full sample. We then examined the impact of racial identity on associations by conducting within‐ and between‐group analyses among Black and White participants.ResultsIn the full sample, lower SES was associated with significantly greater odds of BE and lifetime EDs in men, but not women, across adulthood. The association between lower SES and greater BE risk was stronger for Black men than for White men, though significant in both groups. Conversely, Black women showed a positive association between SES and dimensional ED symptoms that significantly differed from effects for Black men and White women.ConclusionsAssociations between socioeconomic disadvantage and EDs/disordered eating may be particularly robust for men in adulthood, especially men with a marginalized racial identity. Oppositely, Black women may encounter social pressures and minority stress in higher SES environments that could contribute to somewhat heightened ED risk.Public SignificanceLittle is known regarding how associations between socioeconomic status (SES) and eating disorders (EDs) may differ across age/sex or racial identity. We found lower SES was associated with greater odds of a lifetime ED or binge eating in men only, with a particularly strong association between lower SES and binge eating for Black men. Results highlight the importance of examining how SES‐ED associations may differ across other aspects of identity.
Cheilolejeunea zhui (Lejeuneaceae, Marchantiophyta), a new species with moniliate ocelli from Guangxi, China
Authors: Wei Yu‐Mei , Ye Wen , Ho Boon‐Chuan , Tang Qi‐Ming , Harris AJ 
Published: April 2023

AbstractA new ocellate liverwort species, Cheilolejeunea zhui (Lejeuneaceae), is described from Guangxi, China. The new species is similar to the neotropical C. urubuensis in having moniliate ocelli in the leaf lobes and in general appearances but differs in having obliquely spreading leaves, obtuse to subacute leaf apex, thin‐walled leaf cells with distinct trigones, shallowly bifid female bracteole apex, and numerous ocelli in its perianths. Molecular phylogeny of data from three regions (nrITS, trnL–F, and trnG) confirmed the systematic position of this new species to be sister to C. urubuensis, well apart from the remaining members of the genus. Based on morphological and molecular evidence, Cheilolejeunea sect. Moniliocella sect. nov. is proposed to accommodate C. urubuensis and C. zhui. The discovery of C. zhui represents the fourth known species in Cheilolejeunea with linearly arranged ocelli.
Intraspecific trait plasticity to N and P of the wetland invader, Alternanthera philoxeroides under flooded conditions
Authors: Harms Nathan E. , Knight Ian A. , DeRossette A. Blake , Williams Dean A. 
Published: April 2023

AbstractInteractions between invaders and resource availability may explain variation in their success or management efficacy. For widespread invaders, regional variation in plant response to nutrients can reflect phenotypic plasticity of the invader, genetic structure of invading populations, or a combination of the two. The wetland weed Alternanthera philoxeroides (alligatorweed) is established throughout the southeastern United States and California and has high genetic diversity despite primarily spreading clonally. Despite its history in the United States, the role of genetic variation for invasion and management success is only now being uncovered. To better understand how nutrients and genotype may influence A. philoxeroides invasion, we measured the response of plants from 26 A. philoxeroides populations (three cp haplotypes) to combinations of nitrogen (4 or 200 mg/L N) and phosphorus (0.4 or 40 mg/L P). We measured productivity (biomass accumulation and allocation), plant architecture (stem diameter and thickness, branching intensity), and foliar traits (toughness, dry matter content, percent N, and percent P). A short‐term developmental assay was also conducted by feeding a subset of plants from the nutrient experiment to the biological control agent Agasicles hygrophila, to determine whether increased availability of N or P to its host influenced agent performance, as has been previously suggested. Alternanthera philoxeroides haplotype Ap1 was more plastic than other haplotypes in response to nutrient amendments, producing more than double the biomass from low to high N and 50%–68% higher shoot: root ratio than other haplotypes in the high N treatment. Alternanthera philoxeroides haplotypes differed in seven of 10 variables in response to increased N. We found no differences in short‐term A. hygrophila development between haplotypes but mass was 23% greater in high than low N treatments. This study is the first to explore the interplay between nutrient availability, genetic variation, and phenotypic plasticity in invasive characteristics of the global invader, A. philoxeroides.
Prescribed fire alters nematode communities in an old‐field grassland
Authors: Song Min , McDaniel Marshall D. , Zhu Chen , Lin Feng , Zhang Yaojun 
Published: April 2023

AbstractFire is a common disturbance in many biomes, with both beneficial and detrimental effects on soil biology, which largely depend on fire intensity. However, little is known about the impact of fire on soil nematode communities in terrestrial ecosystem. In the present study, we investigated the effects of short‐term prescribed fire on soil nematode communities and soil properties in an old‐field grassland in Northern China. The results showed that burning significantly increased soil nematode abundance by 77% and genus richness by 49% compared to the control. Burning also decreased taxon dominance by 45% (Simpson's D) and increased nematode diversity by 31% (Shannon‐Weaver H'). However, burning increased plant parasites (particularly genera Cephalenchus and Pratylenchus) and shifted community to more bacterial‐feeding genera (i.e., decreased Channel Index). Generally, burning increased soil bio‐available nitrogen (NH4+–N and NO3−–N) content, which would be the main drivers causing nematode community to flourish via a “bottom‐up” effect. These results suggest that prescribed fire increases nematode diversity and alters community composition toward more plant parasites and bacterial feeders. Our findings highlight the importance of prescribed fire management in shaping short‐term nematode community structure and function, but the long‐term effects and impacts of these changes on soil nutrient and carbon cycling remain unknown.
View cells in the hippocampus and prefrontal cortex of macaques during virtual navigation
Authors: Corrigan Benjamin W. , Gulli Roberto A. , Doucet Guillaume , Mahmoudian Borna , Abbass Mohamad , Roussy Megan , Luna Rogelio , Sachs Adam J. , Martinez‐Trujillo Julio C. 
Published: April 2023

AbstractCells selectively activated by a particular view of an environment have been found in the primate hippocampus (HPC). Whether view cells are present in other brain areas, and how view selectivity interacts with other variables such as object features and place remain unclear. Here, we explore these issues by recording the responses of neurons in the HPC and the lateral prefrontal cortex (LPFC) of rhesus macaques performing a task in which they learn new context‐object associations while navigating a virtual environment using a joystick. We measured neuronal responses at different locations in a virtual maze where animals freely directed gaze to different regions of the visual scenes. We show that specific views containing task relevant objects selectively activated a proportion of HPC units, and an even higher proportion of LPFC units. Place selectivity was scarce and generally dependent on view. Many view cells were not affected by changing the object color or the context cue, two task relevant features. However, a small proportion of view cells showed selectivity for these two features. Our results show that during navigation in a virtual environment with complex and dynamic visual stimuli, view cells are found in both the HPC and the LPFC. View cells may have developed as a multiarea specialization in diurnal primates to encode the complexities and layouts of the environment through gaze exploration which ultimately enables building cognitive maps of space that guide navigation.
Risk factors for blood component therapy in parturients—Case–control study
Authors: Gabbai Daniel , Many Ariel , Lerner‐Geva Liat , Attali Emmanuel 
Published: April 2023

AbstractObjectivePostpartum hemorrhage is a major cause of maternal morbidity and mortality, so early identification of patients at risk is crucial. In this study, we aim to assess the risk factors for major transfusion in parturients.MethodsA case–control study was conducted between 2011 and 2019. The cases included women who were treated with postpartum major transfusion compared with two control groups, one of which was treated with 1–2 packed red blood cells and one of which was not treated with packed red blood cells. Cases were matched with controls based on two variables: multiple pregnancies and previous history of three or more cesarean sections. A multivariable conditional logistic regression model was used to determine the role of the independent risk factors.ResultsOf the 187 424 deliveries included in the present study, 246 (0.3%) women were treated with major transfusions. After applying a multivariate analysis, maternal age (odds ratio [OR] 1.07, 95% confidence interval [CI] 0.996–1.16), antenatal anemia with hemoglobin less than 10 g/dL (OR 12.58, 95% CI 2.86–55.25), retained placenta (OR 5.5, 95% CI 2.15–13.78), and cesarean delivery (OR 10.12, 95% CI 0.93–1.95) remained independent risk factors for major transfusions.DiscussionRetained placenta and antenatal anemia (hemoglobin < 10 g/dL) are independent risk factors for major transfusion. Of these, anemia was found to be the most significant.
Mitochondrial Ca2+ overload due to altered proteostasis amplifies apoptosis in C2C12 myoblasts under hypoxia: Protective role of nanocurcumin formulation
Authors: Kushwaha Asha D , Kalra Namita , Varshney Rajeev , Saraswat Deepika 
Published: April 2023

AbstractSevere hypoxia triggers apoptosis leads to myofibers loss and is attributable to impaired intracellular calcium (iCa2+) homeostasis, resulting in reduced muscle activity. Hypoxia increases intracellular Ca2+ by activating the release of Ca2+ from iCa2+ stores, however, the effect of increased [iCa2+] on the mitochondria of muscle cells at high‐altitude hypoxia is largely unexplored. This study examined mitochondrial Ca2+ overload due to altered expression of mitochondrial calcium uptake 1 (MICU1), that is, a gatekeeper of the mitochondrial Ca2+ uniporter, impaired mitochondrial membrane potential (ΔΨm). p53 stabilization and its translocation to the mitochondria were observed following disrupted mitochondrial membrane integrity in myoblasts under hypoxia. Furthermore, the downstream effects of p53 led to the upregulation of proapoptotic proteins (Bax, Caspase‐3, and cytochrome C) in myoblasts under hypoxia. Nanocurcumin‐pyrroloquinoline quinone formulation (NCF; Indian patent no. 302877), developed to address hypoxia‐induced consequences, was found to be beneficial in maintaining mitochondrial Ca2+ homeostasis and limiting p53 translocation into mitochondria under hypoxia in muscle myoblasts. NCF treatment also modulates heat shock proteins and apoptosis‐regulating protein expression in myoblasts. Conclusively, we proposed that mitochondrial Ca2+ overload due to altered MICU1 expression intensifies apoptosis and mitochondrial dysfunctionality. The study also reported that NCF could improve mitochondrial [Ca2+] homeostasis and antiapoptotic ability in C2C12 myoblasts under hypoxia.
Preparation of Ferrocene‐Terminated Dendrimers for the Thermal Decomposition of Ammonium Perchlorate
Authors: Liu Jinyi , Yu Haojie , Wang Li , Chen Tao , Vatsadze Sergey Z. , Chen Dingning , Shen Di , Wang Yu 
Published: April 2023

AbstractAs a common oxidizer, ammonium perchlorate (AP) is an important component in composite solid propellants (CSPs). Ferrocene (Fc)‐based compounds are often selected as burning rate catalysts (BRCs) to catalyze AP decomposition owing to their excellent catalytic behavior. However, one of the drawbacks of Fc‐based BRCs is migration in CSPs. In this study, five Fc‐terminated dendrimers are designed and synthesized to improve the anti‐migration properties, and their chemical structures are confirmed systemically by the related spectra characterization techniques. Moreover, the redox performance, catalytic effect on AP decomposition, combustion performance, and mechanical properties in CSPs are also studied. The shapes of the prepared propellant samples are observed via scanning electron microscopy. The obtained Fc‐based BRCs have good redox performance, a positive effect on promoting AP decomposition, excellent combustion catalytic performance, and good mechanical properties. Meanwhile, they have a higher anti‐migration ability than catocene (Cat) and Fc. This study demonstrates that Fc‐terminated dendrimers have great potential to be applied as anti‐migration BRCs in CSPs.
Bilateral Congenital Ossicular Anomalies: Are the Anomalies Symmetric for Both Ears?
Authors: Yeon Eun‐Kyeong , Son Hyo One , Sung Hanwool John , Choi Jin Woong 
Published: April 2023

AbstractObjectiveTo evaluate whether bilateral congenital ossicular anomalies (COAs) differ regarding ossicular anomalies and hearing loss severities between the ears of the individual.Study DesignRetrospective case review.SettingTertiary referral academic center.MethodsBetween March 2012 and December 2022, 7 consecutive patients (14 ears) with surgically confirmed bilateral COAs were included in the study. Preoperative pure‐tone thresholds, COA classification according to the Teunissen and Cremers system, surgical procedures, and postoperative audiometric results were compared between the 2 ears of each patient.ResultsThe median age of the patients was 11.5 (range: 6‐25) years. Both ears of each patient were categorized based on the same classification. Three patients possessed class III COAs and the other 4 had class I COAs. The interaural differences in preoperative bone and air conduction thresholds were within 15 dB for all patients. Differences in postoperative air‐bone gaps between ears were not statistically significant. The surgical procedures required for ossicular reconstruction were almost identical for both ears.ConclusionThe severity of ossicular abnormalities and hearing loss in patients with bilateral COAs were symmetrical between ears, thereby enabling prediction of the characteristics of the contralateral ear based on the findings observed in 1 ear. These symmetric clinical features can aid surgeons when operating on the contralateral ear.
The incidence of cytomegalovirus and BK polyomavirus infections in kidney transplant patients receiving mTOR inhibitors: A systematic review and meta‐analysis
Authors: Ye Chen , Li Jingjie , Liu Xiaoman , Yan Jiajia , Chen Jie , Wang Changxi , Huang Min , Chen Xiao , Tang Kejing , Chen Pan 
Published: April 2023

AbstractCytomegalovirus (CMV) and BK polyomavirus (BKPyV) infections after kidney transplant have become increasingly prevalent. Based on previous studies, the mammalian target of rapamycin (mTOR) inhibitors seem like attractive alternatives with antiviral activity. The objective of this systematic review and meta‐analysis was to investigate the incidence of CMV and BKPyV infections in kidney transplantation recipients receiving mTOR inhibitors. This meta‐analysis included three comparisons of immunosuppressant regimens commonly used after kidney transplantation: Comparison 1: mTOR inhibitors versus calcineurin inhibitors (CNI); Comparison 2: mTOR inhibitors versus antimetabolites (AM); and Comparison 3: mTOR inhibitors plus a reduced‐dose of CNI versus AM plus a standard‐dose of CNI. The group containing mTOR inhibitors was the study group and the remaining one was the control group. The incidence of CMV or BKPyV infection defined by positive culture, serology, or polymerase chain reaction testing was the primary outcome. A total of 61 studies involving 13,609 patients were included. As compared with the control group, a significantly decreased risk of CMV and BKPyV infections favoring the mTOR inhibitors‐based group was shown in comparisons 1, 2, and 3 (p < 0.05). Compared with the control group in all three comparisons, mTOR inhibitors made no difference in regard to death and graft loss (p > 0.05). Compared with CNI, the incidence of biopsy‐proven acute rejection (BPAR) and anemia was higher with mTOR inhibitors (p < 0.05). In comparisons 2 and 3, the risk of new‐onset diabetes mellitus (NODM) was higher with mTOR inhibitors (p < 0.05). Early introduction of mTOR inhibitors reduced more CMV infections in comparisons 1 and 2 (p < 0.05). The mTOR inhibitor‐based regimen is an attractive alternative with lower risk of CMV and BKPyV infections in kidney transplant recipients. The combination regimen is more appropriate and acceptable than the mTOR‐inhibitor monotherapy‐based regimen. Early introduction of mTOR inhibitors is recommended, although it is worth noting that attention should be paid to wound healing when mTOR inhibitors are introduced early.
Short‐term efficacy and safety of early medical abortion in Japan: A multicenter prospective study
Authors: Osuga Yutaka , Shirasu Kazuhiro , Tsushima Ruriko , Ishitani Ken 
Published: April 2023

AbstractPurposeTo evaluate the short‐term efficacy and safety of a combined mifepristone‐misoprostol regimen in individuals seeking medical abortion at up to 63 days of gestational age.MethodsThis open‐label, multicenter, prospective study evaluated the short‐term efficacy and safety of medical abortion, with the primary outcome being the abortion success rate 24 h after misoprostol administration. The participants received 200 mg of mifepristone orally and 800 μg of misoprostol buccally in the hospital/clinic 36–48 h later. Bleeding and lower abdominal pain, which are the main symptoms associated with medical abortion, were recorded.ResultsThe abortion success rate was 93.3% (95% confidence interval [CI]: 87.3–97.1%) within 24 h of misoprostol administration, 63.3% (95% CI: 54.05–71.94%) within 4 h, and 90.0% (95% CI: 83.18–94.73%) within 8 h. The median time from misoprostol administration to a successful abortion was 3.93 h. Bleeding was most commonly observed 0–4 h prior to the confirmation of gestational sac (GS) expulsion. The most intense lower abdominal pain occurred 0–1 h before the confirmation of GS expulsion.ConclusionThe combined regimen of mifepristone and buccal misoprostol for medical abortion showed short‐term efficacy and a favorable safety profile.