bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antinaturalistische Strategien in Jenseits von Gut und Böse
Authors: Guerreschi Luca 
Published: September 2023

Abstract

Antinaturalistic Strategies in
Beyond Good and Evil
. Naturalistic interpretations of Nietzsche’s thought ultimately appeal to two arguments. On the one hand, when tracing various human phenomena back to processes sufficiently explicable by the natural sciences, it would appear that Nietzsche was pursuing a de facto naturalization program. On the other hand, in BGE 230, the need for the naturalization of human beings as a whole is often interpreted as an argument de jure. After outlining some basic features of contemporary naturalism and showing its incompatibility with Nietzsche’s philosophy, I argue in this paper that neither the de jure nor the de facto argument can be understood in a naturalistic sense. The task of “translating man back into nature” in BGE 230 is indeed turned against a point of view held by “old metaphysical bird-catchers.” An analysis of the manuscript and a comparison of it with the preface to HH I, in which this figure is used in the opposite sense, suggests rather that Nietzsche conceives of the renaturalization of the human in a deceptive way, that is, as one of those numerous “snares and nets for unwary birds” scattered throughout his works. Widening this view, a similar dynamic arises with respect to the de facto argument. In the concluding section, I highlight how, in On the Prejudices of Philosophers, certain naturalization operations are countered by as many arguments to the contrary. Such sudden shifts in perspective seem to indicate, at least in Beyond Good and Evil, a desire to subvert naturalism from within.
UK trial of pressurised intraperitoneal aerosolised chemotherapy (PIPAC) with oxaliplatin for colorectal cancer peritoneal metastases (NCT03868228)
Authors: Kyle Peter , Perry Kitrick , Moutadjer Anne , Gilfillan Nicholas , Webb Rosalind , Basak Dolan , Ziprin Paul , Blunt Dominic , Burn James , Van Ree Katherine , Sergot Antoni , Murphy Jamie 
Published: September 2023

Abstract

Objectives
This is the first UK trial of pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for colorectal cancer peritoneal metastases. This trial aimed to assess the impact of PIPAC in combination with standard of care systemic treatment on: progression free survival (PFS); quality of life (QoL); and short-term complications. In addition, this trial set out to demonstrate that PIPAC can be performed safely in operating theatres within a National Health Service (NHS) setting.

Methods
Single-centre clinical trial with prospective data collection for patients undergoing 8-weekly PIPAC with oxaliplatin at 92 mg/m2 from January 2019 till January 2022. Progression free survival was assessed using peritoneal carcinomatosis index (PCI) by CT scans and laparoscopy. Quality of life was assessed by EORTC QLQ-C30 questionnaire. Adverse events were recorded using CTCAE.

Results
Five patients underwent a total of ten PIPAC administrations (median 2, range 1–4). Median PFS was 6.0 months. QoL was maintained across repeat PIPAC procedures but a decrease in social functioning and increased fatigue were evident. Three incidences of grade 3 adverse events occurred but PIPAC was well tolerated.

Conclusions
The presented data demonstrates that PIPAC is feasible and can be safely delivered within the NHS for patients with colorectal cancer peritoneal metastases, but caution must also be exercised given a risk of adverse events. Systemic chemotherapy can be safely administered at a different unit to the PIPAC procedure if both groups have clear lines of communication and timely data sharing.
Distinct Patterns of Connectivity between Brain Regions Underlie the Intra-Modal and Cross-Modal Value-Driven Modulations of the Visual Cortex
Authors: Antono Jessica Emily , Dang Shilpa , Auksztulewicz Ryszard , Pooresmaeili Arezoo 
Published: September 2023

Past reward associations may be signaled from different sensory modalities; however, it remains unclear how different types of reward-associated stimuli modulate sensory perception. In this human fMRI study (female and male participants), a visual target was simultaneously presented with either an intra- (visual) or a cross-modal (auditory) cue that was previously associated with rewards. We hypothesized that, depending on the sensory modality of the cues, distinct neural mechanisms underlie the value-driven modulation of visual processing. Using a multivariate approach, we confirmed that reward-associated cues enhanced the target representation in early visual areas and identified the brain valuation regions. Then, using an effective connectivity analysis, we tested three possible patterns of connectivity that could underlie the modulation of the visual cortex: a direct pathway from the frontal valuation areas to the visual areas, a mediated pathway through the attention-related areas, and a mediated pathway that additionally involved sensory association areas. We found evidence for the third model demonstrating that the reward-related information in both sensory modalities is communicated across the valuation and attention-related brain regions. Additionally, the superior temporal areas were recruited when reward was cued cross-modally. The strongest dissociation between the intra- and cross-modal reward-driven effects was observed at the level of the feedforward and feedback connections of the visual cortex estimated from the winning model. These results suggest that, in the presence of previously rewarded stimuli from different sensory modalities, a combination of domain-general and domain-specific mechanisms are recruited across the brain to adjust the visual perception.SIGNIFICANCE STATEMENTReward has a profound effect on perception, but it is not known whether shared or disparate mechanisms underlie the reward-driven effects across sensory modalities. In this human fMRI study, we examined the reward-driven modulation of the visual cortex by visual (intra-modal) and auditory (cross-modal) reward-associated cues. Using a model-based approach to identify the most plausible pattern of inter-regional effective connectivity, we found that higher-order areas involved in the valuation and attentional processing were recruited by both types of rewards. However, the pattern of connectivity between these areas and the early visual cortex was distinct between the intra- and cross-modal rewards. This evidence suggests that, to effectively adapt to the environment, reward signals may recruit both domain-general and domain-specific mechanisms.
Negative Emotions Recruit the Parabrachial Nucleus Efferent to the VTA to Disengage Instrumental Food Seeking
Authors: Tsou Jen-Hui , Lee Syun-Ruei , Chiang Chia-Ying , Yang Yi-Jie , Guo Fong-Yi , Ni Shih-Ying , Yau Hau-Jie 
Published: September 2023

The parabrachial nucleus (PBN) interfaces between taste and feeding systems and is also an important hub for relaying distress information and threats. Despite that the PBN sends projections to the ventral tegmental area (VTA), a heterogeneous brain region that regulates motivational behaviors, the function of the PBN-to-VTA connection remains elusive. Here, by using male mice in several behavioral paradigms, we discover that VTA-projecting PBN neurons are significantly engaged in contextual fear, restraint or mild stress but not palatable feeding, visceral malaise, or thermal pain. These results suggest that the PBN-to-VTA input may relay negative emotions under threat. Consistent with this notion, optogenetic activation of PBN-to-VTA glutamatergic input results in aversion, which is sufficient to override palatable feeding. Moreover, in a palatable food-reinforced operant task, we demonstrate that transient optogenetic activation of PBN-to-VTA input during food reward retrieval disengages instrumental food-seeking behaviors but spares learned action–outcome association. By using an activity-dependent targeting approach, we show that VTA DA neurons are disengaged by the PBN afferent activation, implicating that VTA non-DA neurons may mediate PBN afferent regulation. We further show that optogenetic activation of VTA neurons functionally recruited by the PBN input results in aversion, dampens palatable feeding, and disengages palatable food self-administration behavior. Finally, we demonstrate that transient activation of VTA glutamatergic, but not GABAergic, neurons recapitulates the negative regulation of the PBN input on food self-administration behavior. Together, we reveal that the PBN-to-VTA input conveys negative affect, likely through VTA glutamatergic neurons, to disengage instrumental food-seeking behaviors.SIGNIFICANCE STATEMENTThe PBN receives multiple inputs and thus is well positioned to route information of various modalities to engage different downstream circuits to attend or respond accordingly. We demonstrate that the PBN-to-VTA input conveys negative affect and then triggers adaptive prioritized responses to address pertinent needs by withholding ongoing behaviors, such as palatable food seeking or intake shown in the present study. It has evolutionary significance because preparing to cope with stressful situations or threats takes priority over food seeking to promote survival. Knowing how appropriate adaptive responses are generated will provide new insights into circuitry mechanisms of various coping behaviors to changing environmental stimuli.
Remember Me: Vocal Cadenzas as Mementos in Nineteenth-Century Musical Autograph Albums
Authors: Zohn Steven 
Published: September 2023

Abstract
Between the 1830s and the 1880s, leading female singers such as Henriette Rossi Sontag, Laure Cinti-Damoreau, Adelina Patti, and Pauline Viardot participated in a widespread custom of inscribing original vocal cadenzas in autograph albums (also known as friendship albums, keepsake albums, alba amicorum, or Stammbücher). The appeal of album cadenzas, along with other compact inscriptions, reflects a wider Romantic fascination with remembering through small keepsakes such as miniature almanacs and annual compilations of poetry, prose, or music. Whether improvised in the presence of collectors or offered as souvenirs of earlier performances, cadenzas functioned as mementos of musical and social encounters while visually representing singers’ musical personae through performative gestures. These florid pieces also allowed female singers to exercise agency as both creative artists and curators of their public images, much like the (mostly male) composers whose musical signatures fill surrounding album leaves. As performance-practical sources, vocal cadenzas preserve rare and revealing traces of singers’ artistry; many, in fact, can be linked to specific concerts or performances of operas by Bellini, Donizetti, Meyerbeer, Rossini, Verdi, and others. In the case of Cinti-Damoreau, such music illuminates the connection between improvisation, performance, and pedagogy. The gradual disappearance of album cadenzas during the last quarter of the nineteenth century is attributable not only to a waning interest in musical improvisation generally, but also to a shift in creative authority away from singers and toward composers, particularly in the operatic realm.
“Empty Claims of Fellowship”? Erich Doflein, Paul Hindemith, and Übungsmusik as Shared Task
Authors: Haney Joel 
Published: September 2023

Abstract
Studies of the Weimar-era discourse of Gebrauchsmusik (utility music, or music for everyday use) have emphasized Heinrich Besseler’s appropriation of Martin Heidegger’s concept of knowledge gained through immediate participatory experience. Along with Germany’s musical youth movement (Jugendmusikbewegung), Besseler rejected formal concert institutions and promoted musical practices that solicited active involvement in everyday social contexts. The focus on Besseler has kept alive Theodor Adorno’s critique of the amateur movement’s claims of participatory immediacy as being illusory and allied with unreflective, exclusivist elements of National Socialist ideology. Adorno’s assimilation of the prominent Gebrauchsmusik composer Paul Hindemith to a Besselerian/Heideggerian position still informs scholarship, although this view overlooks an alternative paradigm for amateur and school music-making articulated in the late 1920s by the critic and educationist Erich Doflein. Doflein outlined a concept of Übungsmusik (practice music) by intertwining Besselerian elements with a commitment to pedagogical contexts, and by interpreting Hindemith’s compositional strategies as rewarding participants only after challenging their understanding and drawing them into deeply focused, playful activity. Übungsmusik offers a lens for reexamining Hindemith’s collaborations with the music-educational reformers Hilmar Höckner and Edgar Rabsch. Here, ongoing mutual effort formed a precondition for claims of sociomusical connectedness, claims that are further illuminated by the play-centered theory of sociability formulated by the philosophical anthropologist Helmuth Plessner. By bringing together musical knowing and doing at a fundamental level, Doflein’s paradigm is also relevant to recent methodological disputes over music’s object- and event-status.
The implementation of fusion properties calculation to predict wax deposition
Authors: Ismailova Jamilyam , Abdukarimov Aibek , Kabdushev Arman , Taubayev Bakhytzhan 
Published: September 2023

Deposition of wax on the pipe walls is one of the complex flow assurance problems that causes a decrease and complete blockage of oil production rates by reducing the cross-sectional area of flow in the pipelines. In addition, surface facilities require higher energy consumption and failure of facilities due to wax plugging.
Effective design of oil recovery processes requires an adequate prediction of the thermodynamic conditions in which wax can precipitate from crude oil, depending on the pressure, temperature, and composition of the oil.
In this paper, the modified melting and pour point temperatures were presented based on the fluid description. Other fusion properties such as the enthalpy of fusion, the solid-state transition enthalpies, and the heat capacity of fusion have been calculated to modify the multi-solid model for predicting wax deposition.
The proposed modified equations for melting and pour point temperatures were showing reliable agreement with experimental data based on SARA analysis and demonstrated more accurate results compare to literature data.
In order to justify the proposed model, the comparative approach has been implemented between literature, experimental, and data obtained based on proposed solutions.
The detailed description of the Republic of Kazakhstan’s (RoK) oil fields, components from C1 up to C36+ has been used during this research and the most crucial components which tend to form wax precipitation from C15H32 to C20H42 were plotted, which showed an increasing accuracy of 11 % for melting point temperature and 7 % for pour point temperature compared to literature data.
As a result, the proposed modified solutions for fusion properties demonstrated good agreement with literature and obtained results of modifications can be used for further research on Multi solid model of wax precipitation
Development of a model for determining the necessary FPGA computing resource for placing a multilayer neural network on it
Authors: Medetov Bekbolat , Serikov Tansaule , Tolegenova Arai , Zhexebay Dauren , Yskak Asset , Namazbayev Timur , Albanbay Nurtay 
Published: September 2023

In this paper, the object of the research is the implementation of artificial neural networks (ANN) on FPGA. The problem to be solved is the construction of a mathematical model used to determine the compliance of FPGA computing resources with the requirements of neural networks, depending on their type, structure, and size. The number of its LUT (Look-up table – the basic FPGA structure that performs logical operations) is considered as a computing resource of the FPGA.
The search for the required mathematical model was carried out using experimental measurements of the required number of LUTs for the implementation on the FPGA of the following types of ANNs:
– MLP (Multilayer Perceptron);
– LSTM (Long Short-Term Memory);
– CNN (Convolutional Neural Network);
– SNN (Spiking Neural Network);
– GAN (Generative Adversarial Network).
Experimental studies were carried out on the FPGA model HAPS-80 S52, during which the required number of LUTs was measured depending on the number of layers and the number of neurons on each layer for the above types of ANNs. As a result of the research, specific types of functions depending on the required number of LUTs on the type, number of layers, and neurons for the most commonly used types of ANNs in practice were determined.
A feature of the results obtained is the fact that with a sufficiently high accuracy, it was possible to determine the analytical form of the functions that describe the dependence of the required number of LUT FPGA for the implementation of various ANNs on it. According to calculations, GAN uses 17 times less LUT compared to CNN. And SNN and MLP use 80 and 14 times less LUT compared to LSTM. The results obtained can be used for practical purposes when it is necessary to make a choice of any FPGA for the implementation of an ANN of a certain type and structure on it
Determining the deformation properties of crushed rock under compressive compression conditions
Authors: Chepiga Daria , Pakhomov Serhii , Hnatyuk Vitalii , Hryhorets Maksym , Liashok Yaroslav , Podkopaiev Serhii 
Published: September 2023

The object of this study is the process that forms fill materials from crushed rock under load for managing the condition of side rocks in a coal-bearing massif with preparatory workings. Deformation properties of crushed rock under laboratory conditions were evaluated on the basis of a study of compressive compression of the fill material. It was registered that there is a quadratic functional dependence between the change in the bulk density of crushed rock of different granulometric composition and the specific potential energy of deformation. It was experimentally established that the specific potential energy of deformation reaches the limit values at the maximum compression of crushed rock when the fill material consists of parts of different sizes.
For experimental samples with different thickness of the rock layer h0 (m), there was a linear relationship between their longitudinal deformation Dh (m) and the external load F (kN), which determined the behavior of the deforming body at critical levels. Under such conditions, with a relative change in the volume of the fill material dV=0.36, that is, with the same relative deformation at any values of the parameter h0 (m) and the compaction coefficient of the crushed rock kcon=1.57, the maximum stiffness of the rock supports was ensured.
With a limited amount of external static load on the experimental samples, in the process of their deformation when the parameter h0 was reduced by 2 times before their compression, the compaction coefficient of the crushed rock increased from kcon=1.33 to kcon=1.57. At the same time, the specific potential energy of deformation increased by 40 %, which made it possible to ensure the maximum rigidity of the fill material at the minimum value of the longitudinal deformation Dh (m) of the experimental samples
Development of an A1100 aluminum corrugated metal gaskets
Authors: Nurhadiyanto Didik , Mujiyono Mujiyono , Ristadi Febrianto Amri , Fakhri Ardani Ahsanul , Ardeva Gewa , Kusnantoro Muhammad Iqbal , Haruyama Shigeyuki , Yunita Isti , Panichkin Alexander 
Published: September 2023

Corrugated metal gaskets (CMG) made from SUS304 have previously been developed, however a coating process with a softer material is necessary for its design to be optimal. The coating process is time consuming and expensive. This research aims to develop CMG from aluminum by simulation analysis and form a CMG design made of aluminum A1100. The method used is development research. The optimum CMG thickness is analyzed using ANSYS Finite Element Analysis (FEA). The control variables being investigated are contact area and contact stress. The independent variable being investigated is the material thickness of CMG. An aluminum gasket is then constructed using a cold-forming process based on the optimum design. The control variables in the leak test are axial force and water pressure. Experiments were also carried out to test the aluminum gasket for leakage. A leakage test is carried out using a water pressure test. Simulation analysis showed results that were in line with experimental leak tests. FEA simulation results show that the optimum gasket thickness is between 3 and 5 mm, with 5 mm being the most optimal. However, CMG with thicknesses of 4 and 5 have similar contact stress and contact area. Leakage test results also show similarities with simulation results. CMG with a thickness of 5 mm has the best performance. The experimental results show that CMG made from aluminum A1100 is suitable for use as a gasket to prevent leakage, it prevents leakage at fluid pressure up to 12 MPa and axial force 100 kN. The results show that aluminum CMG performs on par with SUS304 CMG coated with nickel or copper. This research succeeded in developing CMG made of aluminum
Determination of quality indicators of sugar fortified with a by-product of elderberry processing
Authors: Samilyk Maryna , Bal’-Prylipko Larysa , Korniienko Daria , Paska Mariia , Ryzhkova Taisia , Yatsenko Ivan , Hnoievyі Ihor , Tkachuk Svetlana , Bolgova Natalia , Sokolenko Viktoriia 
Published: September 2023

Granulated and pressed beet sugar consists of 99.61–99.7 % sucrose, which is a source of energy for the body. However, this product does not contain other vital nutrients. The object of the study is the method of non-waste processing of elderberry fruits. Wild-growing fruits of black elder Sambucus nigra L were used as the subject of the study. Pre-cleaned elder fruits were frozen at a temperature of –18±2 °C, and after defrosting they were subjected to osmotic dehydration. For this, a 70 % sugar solution with a temperature of 50±5 °C was used (hydromodule 1). The duration of osmosis was 1 hour. The derivative product formed as a result of osmotic dehydration of elderberries (elderberry syrup) was used to enrich granulated sugar in an amount of 10 % by weight of sugar. After thorough mixing with the solution, the sugar was dried in a laboratory vacuum dryer. Anthocyanin dyes contained in the elderberries gave the sugar a bright pink color. The resulting product had a characteristic smell and taste of elderberry. The composition of sugar was studied by high-performance liquid chromatography. It was found that sugar enriched with an elderberry derivative contains 0.03±0.02 mg/100 g of vitamin C and 0.28±0.02 % flavonoids. This gives it certain antioxidant properties. In addition to sucrose, glucose (0.20±0.02) and fructose (0.27±0.02) were found in the product by the polarimetric method. Analysis of the amino acid spectrum of enriched sugar showed the presence of 18 amino acids (total amount of 5.547 mg/100 g), including all essential ones. The most found in enriched sugar, mg/100g: tyrosine (0.93), alanine (0.79), phenylalanine (0.752) and leucine (0.749). The results obtained indicate an increase in the biological value and additional functional properties of fortified sugar