bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paisaje social y espacios de tareas en canteras-taller de los Andes centro-sur
Authors: Bobillo Federico Miguel 
Published: May 2023

ResumenEn las canteras-taller los individuos y grupos llevan a cabo diversas actividades vinculadas al aprovisionamiento de recursos líticos. El objetivo de este trabajo es identificar cómo las acciones tecnológicas y prácticas sociales configuraron un paisaje de canteras-taller en Antofagasta de la Sierra (provincia de Catamarca, Argentina). En este sentido, interesa conocer cómo las personas interactuaron con su entorno físico y la variabilidad de actividades que se realizaron en el interior de un paisaje de aprovisionamiento. Para ello se hicieron prospecciones sistemáticas, muestreos, excavaciones y un análisis tecno-tipológico de conjuntos líticos. A partir de este estudio se identificaron loci de actividades con un registro lítico con atributos tecno-tipológicos distintos. Entre los contextos arqueológicos documentados se encuentran campamentos de actividades múltiples, o AET, talleres de reducción de grandes nódulos, o ADT, parapetos (estructuras de muro simple con forma de U), acumulaciones de rocas y reparos rocosos. Cada una de estas áreas de actividades se emplaza en el interior de una zona de canteras-taller y conforma un paisaje social que fue utilizado persistentemente. Precisamente, a partir de esta investigación se logró comprender cómo las personas configuraron un paisaje de tareas a través de sus prácticas sociales y sus modos de habitar un lugar.
New Rightists or Simply Opportunists? The New Right Parties in Power in Latin America and Europe between 2010 and 2019: An Analysis of Their Ideological Dimensions
Authors: López Aguilar Alejandra , Pino Uribe Juan Federico 
Published: May 2023

AbstractThere is a boom in the power of right-wing parties that are becoming government parties in Latin America and Europe. It has been pointed out that these are distinguished from traditional right-wing parties by their common ideology that transcends national contexts, which is why they have been grouped as New Right-wing parties. This article questions whether these parties share ideological themes or whether they are heterogeneous and obey national interests. This study systemizes the New Right-wing parties’ programs and classifies them to answer the question. This corpus is then studied through frequency, network, and principal component analysis. Two conclusions are reached from this. First, these parties agree on issues such as provider States and nationalist claims, and, second, their programs have diverse themes that do not show the formation of an identifiable transnational ideological agenda in their programs. Consequently, grouping these parties as an ideologically homogeneous phenomenon can make invisible the fact that they are parties that adjust to particular demands of their political environment, in a logic that obeys more catch-all parties than ideological and dogmatic parties.
Impact of selection bias on polygenic risk score estimates in healthcare settings
Authors: Lee Younga Heather , Thaweethai Tanayott , Sheu Yi-Han , Feng Yen-Chen Anne , Karlson Elizabeth W. , Ge Tian , Kraft Peter , Smoller Jordan W. 
Published: May 2023

AbstractBackgroundHospital-based biobanks are being increasingly considered as a resource for translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks originate from patient populations, there is a possibility of bias in polygenic risk estimation due to overrepresentation of patients with higher frequency of healthcare interactions.MethodsPRS for schizophrenia, bipolar disorder, and depression were calculated using summary statistics from the largest available genomic studies for a sample of 24 153 European ancestry participants in the Mass General Brigham (MGB) Biobank. To correct for selection bias, we fitted logistic regression models with inverse probability (IP) weights, which were estimated using 1839 sociodemographic, clinical, and healthcare utilization features extracted from electronic health records of 1 546 440 non-Hispanic White patients eligible to participate in the Biobank study at their first visit to the MGB-affiliated hospitals.ResultsCase prevalence of bipolar disorder among participants in the top decile of bipolar disorder PRS was 10.0% (95% CI 8.8–11.2%) in the unweighted analysis but only 6.2% (5.0–7.5%) when selection bias was accounted for using IP weights. Similarly, case prevalence of depression among those in the top decile of depression PRS was reduced from 33.5% (31.7–35.4%) to 28.9% (25.8–31.9%) after IP weighting.ConclusionsNon-random selection of participants into volunteer biobanks may induce clinically relevant selection bias that could impact implementation of PRS in research and clinical settings. As efforts to integrate PRS in medical practice expand, recognition and mitigation of these biases should be considered and may need to be optimized in a context-specific manner.
Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens
Authors: Zheng Ronger , Wang Qiqi , Wu Runbiao , Paradkar Prasad N , Hoffmann Ary A , Wang Guan-Hong 
Published: May 2023

Abstract
Mosquito-borne diseases like dengue and malaria cause a significant global health burden. Unfortunately, current insecticides and environmental control strategies aimed at the vectors of these diseases are only moderately effective in decreasing disease burden. Understanding and manipulating the interaction between the mosquito holobiont (i.e., mosquitoes and their resident microbiota) and the pathogens transmitted by these mosquitoes to humans and animals could help in developing new disease control strategies. Different microorganisms found in the mosquito’s microbiota affect traits related to mosquito survival, development, and reproduction. Here, we review the physiological effects of essential microbes on their mosquito hosts; the interactions between the mosquito holobiont and mosquito-borne pathogen (MBP) infections, including microbiota-induced host immune activation and Wolbachia-mediated pathogen blocking (PB); and the effects of environmental factors and host regulation on the composition of the microbiota. Finally, we briefly overview future directions in holobiont studies, and how these may lead to new effective control strategies against mosquitoes and their transmitted diseases.
Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger
Authors: Liu Qianying , Zhang Xiang , Huang Hui , Chen Yuxin , Wang Fang , Hao Aihua , Zhan Wuqiang , Mao Qiyu , Hu Yuxia , Han Lin , Sun Yifang , Zhang Meng , Liu Zhimin , Li Geng-Lin , Zhang Weijia , Shu Yilai , Sun Lei , Chen Zhenguo 
Published: May 2023

AbstractPendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood pressure. However its molecular structure has remained unknown, limiting our understanding of the structural basis of transport. Here, we determine the cryo-electron microscopy structures of mouse pendrin with symmetric and asymmetric homodimer conformations. The asymmetric homodimer consists of one inward-facing protomer and the other outward-facing protomer, representing coincident uptake and secretion- a unique state of pendrin as an electroneutral exchanger. The multiple conformations presented here provide an inverted alternate-access mechanism for anion exchange. The structural and functional data presented here disclose the properties of an anion exchange cleft and help understand the importance of disease-associated variants, which will shed light on the pendrin exchange mechanism.
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice
Authors: Zhang Yang , Yang Yujie , Yang Fan , Liu Xiaohan , Zhan Ping , Wu Jichao , Wang Xiaojie , Wang Ziying , Tang Wei , Sun Yu , Zhang Yan , Xu Qianqian , Shang Jin , Zhen Junhui , Liu Min , Yi Fan 
Published: May 2023

AbstractRenal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are involved in G2/M arrest of TECs remain unclear. Here, we find that Hdac9 expression is significantly induced in the mouse fibrotic kidneys, especially in proximal tubules, induced by aristolochic acid nephropathy (AAN) or unilateral ureter obstruction (UUO). Tubule-specific deletion of HDAC9 or pharmacological inhibition by TMP195 attenuates epithelial cell cycle arrest in G2/M, then reduces production of profibrotic cytokine and alleviates tubulointerstitial fibrosis in male mice. In vitro, knockdown or inhibition of HDAC9 alleviates the loss of epithelial phenotype in TECs and attenuates fibroblasts activation through inhibiting epithelial cell cycle arrest in G2/M. Mechanistically, HDAC9 deacetylates STAT1 and promotes its reactivation, followed by inducing G2/M arrest of TECs, finally leading to tubulointerstitial fibrosis. Collectively, our studies indicate that HDAC9 may be an attractive therapeutic target for kidney fibrosis.
Structure-evolution-designed amorphous oxides for dielectric energy storage
Authors: Yu Yahui , Zhang Qing , Xu Zhiyu , Zheng Weijie , Xu Jibo , Xi Zhongnan , Zhu Lin , Ding Chunyan , Cao Yanqiang , Zheng Chunyan , Qin Yalin , Li Shandong , Li Aidong , Wu Di , Rabe Karin M. , Liu Xiaohui , Wen Zheng 
Published: May 2023

AbstractRecently, rapidly increased demands of integration and miniaturization continuously challenge energy densities of dielectric capacitors. New materials with high recoverable energy storage densities become highly desirable. Here, by structure evolution between fluorite HfO2and perovskite hafnate, we create an amorphous hafnium-based oxide that exhibits the energy density of ~155 J/cm3with an efficiency of 87%, which is state-of-the-art in emergingly capacitive energy-storage materials. The amorphous structure is owing to oxygen instability in between the two energetically-favorable crystalline forms, in which not only the long-range periodicities of fluorite and perovskite are collapsed but also more than one symmetry, i.e., the monoclinic and orthorhombic, coexist in short range, giving rise to a strong structure disordering. As a result, the carrier avalanche is impeded and an ultrahigh breakdown strength up to 12 MV/cm is achieved, which, accompanying with a large permittivity, remarkably enhances the energy storage density. Our study provides a new and widely applicable platform for designing high-performance dielectric energy storage with the strategy exploring the boundary among different categories of materials.
Sea surface warming patterns drive hydrological sensitivity uncertainties
Authors: Zhang Shipeng , Stier Philip , Dagan Guy , Zhou Chen , Wang Minghuai 
Published: May 2023

AbstractThe increase in global-mean precipitation with global-mean temperature (hydrological sensitivity; $$\eta$$
η
) is constrained by the atmospheric energy budget, but its magnitude remains uncertain. Here we apply warming patch experiments to a climate model to demonstrate that the spatial pattern of sea surface warming can explain a wide range of $$\eta$$
η
. Warming in tropical strongly ascending regions produces $$\eta$$
η
values even larger than suggested by the Clausius–Clapeyron relationship (7% K−1), as the warming and moisture increases can propagate vertically and be transported globally through atmospheric dynamics. Differences in warming patterns are as important as different treatments of atmospheric physics in determining the spread of $$\eta$$
η
in climate models. By accounting for the pattern effect, the global-mean precipitation over the past decades can be well reconstructed in terms of both magnitude and variability, indicating the vital role of the pattern effect in estimating future intensification of the hydrological cycle.
Climate co-benefits of tiger conservation
Authors: Lamba Aakash , Teo Hoong Chen , Sreekar Rachakonda , Zeng Yiwen , Carrasco Luis Roman , Koh Lian Pin 
Published: May 2023

AbstractBiodiversity conservation is increasingly being recognized as an important co-benefit in climate change mitigation programmes that use nature-based climate solutions. However, the climate co-benefits of biodiversity conservation interventions, such as habitat protection and restoration, remain understudied. Here we estimate the forest carbon storage co-benefits of a national policy intervention for tiger (Panthera tigris) conservation in India. We used a synthetic control approach to model avoided forest loss and associated carbon emissions reductions in protected areas that underwent enhanced protection for tiger conservation. Over a third of the analysed reserves showed significant but mixed effects, where 24% of all reserves successfully reduced the rate of deforestation and the remaining 9% reported higher-than-expected forest loss. The policy had a net positive benefit with over 5,802 hectares of averted forest loss, corresponding to avoided emissions of 1.08 ± 0.51 MtCO2equivalent between 2007 and 2020. This translated to US$92.55 ± 43.56 million in ecosystem services from the avoided social cost of emissions and potential revenue of US$6.24 ± 2.94 million in carbon offsets. Our findings offer an approach to quantitatively track the carbon sequestration co-benefits of a species conservation strategy and thus help align the objectives of climate action and biodiversity conservation.
An examination of how six reasons for valuing nature are endorsed and associated with pro-environmental behavior across 12 countries
Authors: Gainsburg Izzy , Roy Sukanya , Cunningham Julia Lee 
Published: May 2023

AbstractBalanced samples from 12 countries (N = 12,000) were surveyed about their reasons for valuing nature and pro-environmental behaviors. Results showed that people were least likely to endorse moral-based reasons for valuing nature, as compared to five other reasons (wellbeing benefits, nature’s intrinsic value, health benefits, economic value, identity-based reasons). However, moral- and identity-based reasons (relative to the other four reasons) for valuing nature were the strongest predictors of pro-environmental behavior across three different methods (correlations, linear mixed models, and relative importance analysis) and two pro-environmental behavior categories (consumer behavior and activism). In other words, the reasons for valuing nature most associated with pro-environmental behavior also garnered the weakest support, presenting a potential dilemma for those hoping to leverage values to promote pro-environmental behavior. We also identify a possible mechanism (awareness of one’s environmental impact) to explain why moral- and identity-based reasons for valuing nature best predict behavior. Finally, we examine between-country variability in the endorsement of the six reasons and the reasons’ associations with pro-environmental behaviors, and country-level factors that may explain between-country variability in these outcomes. We discuss these results in the context of broader literature that has focused on an intrinsic vs. instrumental valuation of nature dichotomy.
Taxonogenomics of Culturomica massiliensis gen. nov., sp. nov., and Emergencia timonensis gen. nov., sp. nov. new bacteria isolated from human stool microbiota
Authors: Hamame Afaf , Magdy Wasfy Reham , Lo Cheikh Ibrahima , Fenollar Florence , Raoult Didier , Fournier Pierre-Edouard , Houhamdi Linda 
Published: May 2023

AbstractTwo new bacterial strains, Marseille-P2698T (CSUR P2698 = DSM 103,121) and Marseille-P2260T (CSUR P2260 = DSM 101,844 = SN18), were isolated from human stools by the culturomic method. We used the taxonogenomic approach to fully describe these two new bacterial strains. The Marseille-P2698T strain was a Gram-negative, motile, non-spore-forming, rod-shaped bacterium. The Marseille-P2260T strain was a Gram-positive, motile, spore-forming rod-shaped bacterium. Major fatty acids found in Marseille-P2698T were C15:0 iso (63%), C15:0 anteiso (11%), and C17:0 3-OH iso (8%). Those found in Marseille-P2260T strain were C16:00 (39%), C18:1n9 (16%) and C18:1n7 (14%). Strains Marseille-P2698T and Marseille-P2260T had 16S rRNA gene sequence similarities of 91.50% with Odoribacter laneusT, and of 90.98% and 95.07% with Odoribacter splanchnicusT and Eubacterium sulciT, respectively. The exhibited digital DNA-DNA Hybridization values lower than 20.7%, and Orthologous Average Nucleotide Identity values lower than 73% compared to their closest related bacterial species O. splanchnicusT and E. sulciT respectively. Phenotypic, biochemical, phylogenetic, and genomic results obtained by comparative analyses provided sufficient evidence that both of the two studied strains Marseille-P2698T and Marseille-P2260T are two new bacterial species and new bacterial genera for which the names Culturomica massiliensis gen. nov., sp. nov., and Emergencia timonensis gen. nov., sp. nov. were proposed, respectively.
Using machine learning to predict processes and morphometric features of watershed
Authors: Mokarram Marzieh , Pourghasemi Hamid Reza , Tiefenbacher John P. 
Published: May 2023

AbstractThe research aims to classify alluvial fans’ morphometric properties using the SOM algorithm. It also determines the relationship between morphometric characteristics and erosion rate and lithology using the GMDH algorithm. For this purpose, alluvial fans of 4 watersheds in Iran are extracted semi-automatically using GIS and digital elevation model (DEM) analysis. The relationships between 25 morphometric features of these watersheds, the amount of erosion, and formation material are investigated using the self-organizing map (SOM) method. Principal component analysis (PCA), Greedy, Best first, Genetic search, Random search as feature selection algorithms are used to select the most important parameters affecting erosion and formation material. The group method of data handling (GMDH) algorithm is employed to predict erosion and formation material based on morphometries. The results indicated that the semi-automatic method in GIS could detect alluvial fans. The SOM algorithm determined that the morphometric factors affecting the formation material were fan length, minimum height of fan, and minimum fan slope. The main factors affecting erosion were fan area (Af) and minimum fan height (Hmin-f). The feature selection algorithm identified (Hmin-f), maximum fan height (Hmax-f), minimum fan slope, and fan length (Lf) to be the morphometries most important for determining formation material, and basin area, fan area, (Hmax-f) and compactness coefficient (Cirb) were the most important characteristics for determining erosion rates. The GMDH algorithm predicted the fan formation materials and rates of erosion with high accuracy (R2 = 0.94, R2 = 0.87).
Wolbachia protects Drosophila melanogaster against two naturally occurring and virulent viral pathogens
Authors: Bruner-Montero Gaspar , Jiggins Francis M. 
Published: May 2023

AbstractWolbachiais a common endosymbiont that can protect insects against viral pathogens. However, whether the antiviral effects ofWolbachiahave a significant effect on fitness remains unclear. We have investigated the interaction betweenDrosophila melanogaster, Wolbachiaand two viruses that we recently isolated from wild flies, La Jolla virus (LJV;Iflaviridae) and Newfield virus (NFV;Permutotetraviridae). Flies infected with these viruses have increased mortality rates, and NFV partially sterilizes females. These effects on fitness were reduced inWolbachia-infected flies, and this was associated with reduced viral titres. However,Wolbachiaalone also reduces survival, and under our experimental conditions these costs of the symbiont can outweigh the benefits of antiviral protection. In contrast, protection against the sterilizing effect of NFV leads to a net benefit ofWolbachiainfection after exposure to the virus. These results support the hypothesis thatWolbachiais an important defense against the natural pathogens ofD. melanogaster.Furthermore, by reducing the cost ofWolbachiainfection, the antiviral effects ofWolbachiamay aid its invasion into populations and help explain why it is so common in nature.
Predicting lymphovascular invasion in rectal cancer: evaluating the performance of golden-angle radial sparse parallel MRI for rectal perfusion assessment
Authors: Fan Yingying , Chen Meining , Huang Hongyun , Zhou Mi 
Published: May 2023

AbstractThis study aims to determine whether the dual-parameter approach combined with either time-resolved angiography with stochastic trajectories (TWIST) or golden-angle radial sparse parallel (GRASP) and diffusion-weighted imaging (DWI) has superior diagnostic performance in predicting pathological lymphovascular invasion (pLVI) rectal cancer when compared with traditional single-parameter evaluations using DWI alone. Patients with pathologically confirmed rectal cancer were enrolled. Perfusion (influx forward volume transfer constant [Ktrans] and rate constant [Kep]) and apparent diffusion coefficient (ADC) were measured by two researchers. For both sequences, areas under receiver operating characteristic (ROCs) to predict pLVI-positive rectal cancer were compared. A total of 179 patients were enrolled in our study. A combined analysis of ADC and perfusion parameters (Ktrans) acquired with GRASP yielded a higher diagnostic performance compared with diffusion parameters alone (area under the curve, 0.91 ± 0.03 vs. 0.71 ± 0.06, P < 0.001); However, ADC with GRASP-acquired Kep and ADC with TWIST-acquired perfusion parameters (Ktrans or Kep) did not offer any additional benefit. The Ktrans of the GRASP technique improved the diagnostic performance of multiparametric MRI to predict rectal cancers with pLVI-positive. In contrast, TWIST did not achieve this effect.
Development of Social-Pragmatic Understanding in Children With Congenital Hearing Loss and Typical Hearing Between the Ages of 4 and 6 Years
Authors: Tuohimaa Krista , Loukusa Soile , Löppönen Heikki , Välimaa Taina , Kunnari Sari 
Published: May 2023

Purpose:
This prospective longitudinal study aimed to explore (a) the development of social-pragmatic understanding of children with bilateral hearing aids (BiHAs), bilateral cochlear implants (BiCIs), and typical hearing (TH) between the ages of 4 and 6 years and (b) group differences between children with BiHAs, BiCIs, and TH.

Method:
The Pragma test was used for a comprehensive assessment of social-pragmatic understanding of a total of 86 children: 19 children with BiHAs, 22 children with BiCIs, and 45 children with TH. The Pragma test requires answering socially and contextually demanding questions and explaining the right answers. The explanation tasks are targeted at studying the participant's own awareness of the inferencing process. The children in this study were assessed yearly at the ages of 4, 5, and 6 years.

Results:
The participants with BiHAs, BiCIs, and TH showed significant development in their social-pragmatic understanding between the ages of 4 and 6 years, but most children with hearing loss (HL) still did not meet age expectations at the age of 6 years. Children with BiHAs and BiCIs both showed large-scale inferential difficulties, including utilizing theory of mind, utilizing verbal and visual information, and understanding conversational norms and emotions in context.

Conclusions:
Children with BiHAs and BiCIs are at risk of delays in social-pragmatic understanding despite early detection of HL, early amplification, and cochlear implantation. Therefore, the social-pragmatic abilities of children with HL should be assessed regularly, and the children with HL should have early access to social-pragmatic interventions where utilizing contextual information is practiced comprehensively.