bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of response to incentive recruitment strategies in a social media-based survey
Authors: Ichimiya Megumi , Muller-Tabanera Hope , Cantrell Jennifer , Bingenheimer Jeffrey B , Gerard Raquel , Hair Elizabeth C , Donati Dante , Rao Nandan , Evans W Douglas 
Published: June 2023

Objective This study aimed to examine varying incentives on acceptance to participate in an online survey on social media and to identify related demographic factors. Methods The study used Facebook and targeted its users aged 18 to 24 years in the United States. During recruitment, participants were randomized to one of the three types of incentives for survey completion, (1) a $5 gift card, (2) a lottery for a $200 gift card, and (3) a $5 gift card plus a lottery for a $200 gift card. Acceptance rates for survey participation were compared across three incentives using percentages, 95% logit-transformed confidence intervals, and Pearson’s chi-squared tests. The survey asked about cognition and behaviors around smoking and vaping. Results The ads had 1,782,931 impressions, 1,104,139 reaches, and 11,878 clicks. The average ad frequency was 1.615, and the click-through rate was 0.67%. Males clicked less than females when seeing the ads. The acceptance rates for the three incentives were 63.7%, 37.2%, and 64.6%, respectively. A Chi-square test confirmed that the lottery-only group had a lower acceptance rate compared to those guaranteed an incentive, including the gift card group and the gift card and lottery group. Further analyses indicated that males did not opt into the survey as often as females when given the lottery-only incentive option, and those who did not meet their financial expenses opted into the survey more often than those who had more money than their expenses when given the lottery-only incentive option. Conclusions This study suggests that incentives guaranteed to all participants, even if the incentive's value is small, may lead to higher acceptance rates compared to a lottery for a greater incentive in social media-based surveys.
MonDiaL-CAD: Monkeypox diagnosis via selected hybrid CNNs unified with feature selection and ensemble learning
Authors: Attallah Omneya 
Published: June 2023

Objective Recently, monkeypox virus is slowly evolving and there are fears it will spread as COVID-19. Computer-aided diagnosis (CAD) based on deep learning approaches especially convolutional neural network (CNN) can assist in the rapid determination of reported incidents. The current CADs were mostly based on an individual CNN. Few CADs employed multiple CNNs but did not investigate which combination of CNNs has a greater impact on the performance. Furthermore, they relied on only spatial information of deep features to train their models. This study aims to construct a CAD tool named “Monkey-CAD” that can address the previous limitations and automatically diagnose monkeypox rapidly and accurately. Methods Monkey-CAD extracts features from eight CNNs and then examines the best possible combination of deep features that influence classification. It employs discrete wavelet transform (DWT) to merge features which diminishes fused features' size and provides a time-frequency demonstration. These deep features’ sizes are then further reduced via an entropy-based feature selection approach. These reduced fused features are finally used to deliver a better representation of the input features and feed three ensemble classifiers. Results Two freely accessible datasets called Monkeypox skin image (MSID) and Monkeypox skin lesion (MSLD) are employed in this study. Monkey-CAD could discriminate among cases with and without Monkeypox achieving an accuracy of 97.1% for MSID and 98.7% for MSLD datasets respectively. Conclusions Such promising results demonstrate that the Monkey-CAD can be employed to assist health practitioners. They also verify that fusing deep features from selected CNNs can boost performance.
Remote vision testing of central retinal acuity and comparison with clinic-based Snellen acuity testing in patients followed for retinal conditions
Authors: Chen Earnest P , Mills Michael , Gallagher Tara , Polis Andrew , Blasberg Sophie , Pham Peter , Gentile Ronald C , Ianchulev Tsontcho ,   (The Accustat Study Group)
Published: June 2023

Introduction The unmet need for remote monitoring of visual function with home-based, patient-centric technologies became increasingly palpable during the COVID-19 pandemic. Many patients with chronic eye conditions lack access to office-based examinations. Here, we evaluate the efficacy of the Accustat® test, a virtual application for measuring near visual acuity on any portable electronic device via telehealth. Materials and methods Thirty-three adult subjects from the telehealth remote monitoring service of a retina practice performed the Accustat® acuity testing at home. All patients underwent in-office general eye examination with additional fundoscopic examination and optical coherence tomography retina imaging. Best corrected visual acuity assessment using a Snellen chart was compared with remote visual acuity assessment with the Accustat® test. Visual acuity was analyzed and compared between the best-corrected near visual acuity potential achieved on the Accustat® and in-office distance best-corrected Snellen visual acuity. Results The mean logarithm of the minimum angle of resolution (logMAR) visual acuities of all eyes tested using the Accustat test was 0.19 ± 024 and for the office Snellen test 0.21 ±  0.21. A linear regression model with 95% confidence intervals reveals that there is a strong linear relationship between Accustat logMAR and office Snellen logMAR. Bland–Altman analysis demonstrated 95.2% significant agreement between Accustat and Office Snellen’s best corrected visual acuity. Intraclass correlation coefficient (ICC = 0.94) demonstrated a strong positive correlation between at home versus office visual acuity. Conclusion There was a high correlation between the visual acuity measured with the Accustat near vision digital self-test and the office Snellen acuity test, suggesting the potential utility of scalable remote monitoring of central retinal function via telehealth.
Exploring the mass adoption potential of wearable fitness devices in Malaysia
Authors: Hayat Naeem , Salameh Anas A , Mamun Abdullah Al , Alam Syed Shah , Zainol Noor Raihani 
Published: June 2023

Objective The current study explores the formation of an intention to use wearable fitness devices (WFDs) with wearable fitness attributes and health consciousness (HCS). Moreover, the research examines the use of WFDs with the health motivation (HMT) and intention to use WFDs. The study also exposes the moderating effect of HMT between the intention to use WFDs and the use of WFDs. Methods Five hundred and twenty-five adults participated in the current study, and data were collected from January 2021 to March 2021 through the online survey of Malaysian respondents. The cross-sectional data was analyzed using the second-generation statistical method of partial least square structural equation modeling. Results HCS is insignificantly associated with the intention to use WFDs. Perceived compatibility, perceived product value, perceived usefulness, and perceived technology accuracy significantly influence the intention to use WFDs. HMT significantly impacts the adoption of WFDs; however, the intention to use WFDs negatively but significantly influences the use of WFDs. Lastly, the association between the intention to use WFDs and the adoption of WFDs is significantly moderated by HMT. Conclusions Our study findings illuminate the significant impact of technology-level attributes of WFDs on the intention to use WFDs. However, an insignificant impact of HCS on the intention to use WFDs was reported. Our result confirms that HMT plays a significant role in the use of WFDs. Such as the moderating role of HMT is vital to transform the intention to use WFDs into the adoption of WFDs.
Activated Prothrombin Complex Concentrate in Pediatric Cardiac Patients, Our Early Experience
Authors: Ashikhmina Swan Elena , Brinkman Nathan J. , Lahr Brian D. , Nemergut Michael E. , Dearani Joseph A. , Stephens Elizabeth H. 
Published: June 2023

Background Pediatric cardiac surgery is associated with abnormal coagulation, bleeding, and nearly ubiquitous transfusions. With the popularization of patient blood management, attempts are being made to decrease liberal transfusions by administering prothrombin complex concentrates (PCCs). The safety and efficacy of PCCs in adult cardiac surgery has been studied extensively, but only few reports address this in children. We performed an observational study focused on transfusion requirements after off-label use of activated PCC Factor Eight Inhibitor Bypassing Activity (FEIBA) as an adjunct to post-cardiopulmonary bypass (CPB) hemostatic protocol. Methods We reviewed the medical records of children ≤15 kg undergoing cardiac operations with CPB between May 2018 and March 2022. A propensity score (PS) analysis was performed to identify matched pairs of patients who did and did not receive FEIBA. Results Out of 210 patients who met the inclusion criteria, 44 patients received FEIBA. Propensity score-based analysis identified 40 matched pairs of patients with similar baseline characteristics. There was no statistically significant difference in the primary outcome—the volume of transfusion after CPB, which included all allogeneic blood products and salvaged washed red cells administered after protamine. Specifically, FEIBA patients were transfused 28 (22-34) mL/kg and controls were transfused 22 (11-49) mL/kg, P = .989. Upon arrival to ICU, the FEIBA group averaged an 8% lower international normalized ratio, compared with the controls ( P = .009) and a 1.08 g/dL higher hemoglobin ( P = .050). Neither difference remained significant on POD 1. Conclusions In this exploratory study, we found no change in transfusion requirements after CPB despite FEIBA administration.
Osteoporosis in the Setting of Shoulder Arthroplasty: A Narrative Review
Authors: Daher Mohammad , Fares Mohamad Y. , Boufadel Peter , Khanna Akshay , Zalaquett Ziad , Abboud Joseph A. 
Published: June 2023

Patients who undergo shoulder surgery are frequently affected by osteoporosis and osteopenia, and the prevalence of this association is expected to increase due to the growing number of elderly individuals undergoing these procedures. It may be advisable to conduct a preoperative DXA scan for orthopedic surgical candidates at high risk, to detect those who could benefit from early intervention and avoid any related adverse events. Some of these complications include periprosthetic fractures, infection, subsequent fragility fractures, and have an all-cause revision arthroplasty at 2 years post-op. Some studies analyzed the beneficence of antiresorptive medications pre-operatively but the latter did not show favorable outcomes. Surgical management may include cementing components of the prosthesis as well as modifying the diameter of the shoulder stem. Nevertheless, more studies are needed to evaluate the efficacy of any intervention, whether medical or surgical, to avoid any shoulder arthroplasty related-complication that may be precipitated by the reduced bone mineral density.
Exercise Therapy for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis
Authors: Mo Ling , Jiang Banghua , Mei Tao , Zhou Daihua 
Published: June 2023

Background: Exercise is an effective nonpharmaceutical therapy for knee osteoarthritis (KOA). Purpose: To identify the most effective type of exercise therapy for KOA with regard to pain, stiffness, joint function, and quality of life. Study Design: Systematic review; Level of evidence, 3. Methods: The PubMed, Web of Science, Embase, and Cochrane Library databases were searched, from inception to April 4, 2022. Included were randomized controlled trials that assessed the efficacy on KOA among 5 different exercise therapy groups (aquatic exercise [AE], stationary cycling [CY], resistance training [RT], traditional exercise [TC], and yoga [YG]) and compared with the control group. Outcomes among the groups were assessed with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), 6-minute walk test (6-MWT), visual analog scale (VAS) for pain, and Knee injury and Osteoarthritis Outcome Score (KOOS); weighted mean differences (WMDs) and 95% confidence intervals were calculated. Network meta-analyses comparing outcomes between all groups and with controls were performed, and group rankings were calculated using the surface under the cumulative ranking curve (SUCRA). Results: A total of 39 studies (N = 2646 participants) were included. Most of the studies failed to blind participants and researchers, resulting in a high risk of performance bias. Significantly worse WOMAC-Pain scores were seen in controls compared with all exercise interventions except AE (WMD [95% CI]: CY, –4.45 [–5.69 to –3.20]; RT, –4.28 [–5.48 to –3.07]; TC, –4.20 [–5.37 to –3.04]; and YG, –0.57 [–1.04 to –1.04]), and worse scores were seen in controls compared with YG regarding WOMAC-Stiffness (WMD, –1.40 [95% CI, –2.45 to –0.34]) and WOMAC-Function (WMD, –0.49 [95% CI, –0.95 to –0.02]). According to the SUCRA, CY was the most effective for improving WOMAC-Pain (80.8%) and 6-MWT (76.1%); YG was most effective for improving WOMAC-Stiffness (90.6%), WOMAC-Function (77.4%), KOOS–Activities of Daily Living (72.0%), and KOOS–Quality of Life (79.1%); AE was the most effective regarding VAS pain (77.2%) and KOOS-Pain (64.0%); and RT was the most effective regarding KOOS-Symptoms (84.5%). Conclusion: All 5 types of exercise were able to ameliorate KOA. AE (for pain relief) and YG (for joint stiffness, limited knee function, and quality of life) were the most effective approaches, followed by RT, CY, and TC.
Arabic Translation of the Knee Outcome Survey–Sports Activities Scale With Cross-cultural Adaptation and Validation
Authors: Alrabai Hamza M. , Algarni Abdulrahman D. , Alshehri Abdulrahman Ahmed , Alshihri Adel Faiz , Almansour Ammar Saleh , Alrawaf Rawaf Khalid , Al-Ahaideb Abdulaziz S. 
Published: June 2023

Background: There are few sports-specific knee functional scales in the Arabic language. The Knee Outcome Survey–Sports Activities Scale (KOS-SAS) is a validated sports-specific patient-reported outcome measure that assesses knee function in an athletic population. Purpose: To provide a validated Arabic version of the KOS-SAS (KOS-SAS-Ar) while achieving cross-cultural adaptation for use in an Arabic-speaking population with sports-related knee disorders. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: There were 2 independent translators who conducted a forward translation of the KOS-SAS, followed by a backward translation by different translators. Subsequently, researchers and expert invitees judged the conceptual content and cultural adaptations of the final translation. A total of 276 patients completed the KOS-SAS-Ar as well as the International Knee Documentation Committee (IKDC) subjective assessment of knee function and a visual analog scale (VAS) for pain. Statistical analysis was performed for test-retest reliability, convergent validity, construct validity, and factor analysis. Results: The test-retest reliability of the KOS-SAS-Ar was high ( r = 0.9). The items of the KOS-SAS-Ar had statistically significant internal consistency, with a Cronbach alpha of .924 ( P < .0001). The KOS-SAS-Ar Symptoms subscore correlated with the VAS pain score ( P < .0001), and the KOS-SAS-Ar Functional Limitations subscore correlated with the IKDC subjective score ( P < .0001). The construct validity of the KOS-SAS-Ar was satisfactory (Kaiser-Meyer-Olkin value = 0.868; Bartlett test: P < .0001). Factor analysis showed a statistical correlation among the 11 items of the KOS-SAS-Ar. Conclusion: The KOS-SAS-Ar demonstrated favorable reliability and validity, and it appears to be a suitable tool for Arabic-speaking patients with sports-related knee conditions.
Translation and Validation of a Simplified Chinese Version of the Anterior Cruciate Ligament–Quality of Life Questionnaire
Authors: Kou Jun , Deng Bing , Liu Jinbiao , Wen Jun , Yin Li , Xie Qingyun , Wei Wang 
Published: June 2023

Background: The Anterior Cruciate Ligament–Quality of Life (ACL-QOL) questionnaire is a widely used and effective scale for quality of life in patients with chronic anterior cruciate ligament (ACL) injury. Purpose: To translate and adapt the ACL-QOL questionnaire for Chinese patients and evaluate its reliability, validity, and responsiveness in this population. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Translation and adaptation were conducted in accordance with the guidelines of the A merican Academy of Orthopaedic Surgeons Outcome Committee. Included were 121 patients who were diagnosed with a chronic ACL injury and underwent ACL reconstruction between January 2020 and June 2021. Preoperatively, patients completed the simplified Chinese version of the ACL-QOL (ACL-QOL-C), the Knee injury and Osteoarthritis Outcome Score, and the 12-Item Short Form Health Survey. The ACL-QOL-C was also completed at 12- and 24-week follow-ups. Psychometric evaluations were then performed and included score distribution, internal consistency, test-retest reliability, construct validity, and responsiveness. Results: The Cronbach alpha ranged from .905 to .975, indicating excellent internal consistency, and the intraclass correlation coefficient ranged from 0.864 to 0.985, indicating excellent test-retest reliability. The consistency between the above results and our a priori hypotheses was more than 70% (35/42), indicating good construct validity. The standard error of measurement and effect size of the total score and each item of the ACL-QOL-C were >0.8 at the final follow-up, indicating good responsiveness. Conclusion: The English version of the ACL-QOL has been successfully translated into Chinese, and it has been shown to be applicable for the assessment of the quality of life in Chinese patients with chronic ACL injury.
Intervention for Prevention of Type 2 Diabetes Mellitus Among Prediabetes: A Review of the Literature
Authors: Thipsawat Sopida 
Published: June 2023

Introduction In recent decades, the prevalence and incidence of type 2 diabetes mellitus (T2DM) have increased rapidly and represent a significant public health problem worldwide. Long-term T2DM is associated with microvascular complications such as retinopathy, nephropathy, and neuropathy. Prediabetes is a state of hyperglycemia with blood glucose levels higher than normal but lower than the diabetes threshold. Several studies have demonstrated the effectiveness of lifestyle interventions that resulted in a 40% to 70% reduction in diabetes mellitus in adults with prediabetes. These interventions focused on increased physical activity and dietary changes that were able to prevent or delay the onset of T2DM in prediabetes. However, most review studies focused on interventions to prevent T2DM in high-risk groups such as obesity. There was a limitation of reports related to prediabetes. Nevertheless, it remains a high-risk condition for the development of T2DM with a conversion rate of 5% to 10% per year. Therefore, the aim of this study was to review the current evidence on intervention studies aimed at reducing the incidence of type 2 diabetes in prediabetes. Method The researcher conducted a literature search of common online databases such as Medline, Google Scholar, and Cochrane Library between January 2011 and December 2021. Result The intervention for the prevention of T2DM in prediabetes consisted of a lifestyle intervention, a nutritional supplementation intervention, and a pharmacological intervention Conclusion Several studies suggest that T2DM in prediabetes can be prevented by lifestyle modification and pharmacological interventions, or a combined intervention. However, further interventions may be needed to confirm this.
Activating Life Course Theory through a Whole System Prevention Framework to Address the Wicked Problem of Maternal and Infant Morbidity and Mortality
Authors: LaFave Lea Ayers , Clemmons Naomi , Kotelchuck Milton , Morales Cozier Naima , Geltman Ana , Browne Dianne R. , Kenyon Katie 
Published: June 2023

Background Racial/ethnic disparities in maternal and infant morbidity and mortality (MIM&M) is a wicked problem that is reinforced and perpetuated by our system[s] of care. Life Course Theory (LCT) helps to explain drivers of health disparities, but its application is challenged. An upstream approach that promotes systemic change requires the implementation of an expanded prevention framework that includes primordial and quaternary prevention. Research Design We developed an innovative expanded Whole System Prevention Framework (WSPF) that incorporates LCT, prevention (including primordial and quaternary prevention) and systems thinking. Study Sample We implemented this new conceptual Framework with two Healthy Start community partnerships through training, service mapping, and strategic planning to address upstream drivers of MIM&M. Data Collection and Analysis Service mapping revealed few Healthy Start upstream activities/services with the predominance being delivered downstream at the program (microsystem) level. Results Service mapping provided a snapshot of the current service distribution of services across the systems. The preponderance were primary, secondary and tertiary prevention activities (75.5% and 65.6%) delivered at the program level (58.2% and 68%), revealing opportunities for upstream strategies to promote equity. The implementation process provided a new way to frame strategic planning and develop upstream strategies to promote health equity and reduce MIM&M. Conclusion The Whole System Prevention Framework and its implementation methodology could be applied to address other wicked problems.
Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized study
Authors: Fenaux Pierre , Gobbi Marco , Kropf Patricia L. , Issa Jean-Pierre J. , Roboz Gail J. , Mayer Jiri , Krauter Jürgen , Robak Tadeusz , Kantarjian Hagop , Novak Jan , Jedrzejczak Wieslaw. W. , Thomas Xavier , Ojeda-Uribe Mario , Miyazaki Yasushi , Min Yoo Hong , Yeh Su-Peng , Brandwein Joseph , Gercheva-Kyuchukova Liana , Demeter Judit , Griffiths Elizabeth , Yee Karen , Döhner Konstanze , Hao Yong , Keer Harold , Azab Mohammad , Döhner Hartmut 
Published: June 2023

Abstract
This phase 3 study evaluated the efficacy and safety of the new hypomethylating agent guadecitabine (n = 408) vs a preselected treatment choice (TC; n = 407) of azacitidine, decitabine, or low-dose cytarabine in patients with acute myeloid leukemia unfit to receive intensive induction chemotherapy. Half of the patients (50%) had poor Eastern Cooperative Oncology Group Performance Status (2-3). The coprimary end points were complete remission (19% and 17% of patients for guadecitabine and TC, respectively [stratified P = .48]) and overall survival (median survival 7.1 and 8.5 months for guadecitabine and TC, respectively [hazard ratio, 0.97; 95% confidence interval, 0.83-1.14; stratified log-rank P = .73]). One- and 2-year survival estimates were 37% and 18% for guadecitabine and 36% and 14% for TC, respectively. A large proportion of patients (42%) received &lt;4 cycles of treatment in both the arms. In a post hoc analysis of patients who received ≥4 treatment cycles, guadecitabine was associated with longer median survival vs TC (15.6 vs 13.0 months [hazard ratio, 0.78; 95% confidence interval, 0.64-0.96; log-rank P = .02]). There was no significant difference in the proportion of patients with grade ≥3 adverse events (AEs) between guadecitabine (92%) and TC (88%); however, grade ≥3 AEs of febrile neutropenia, neutropenia, and pneumonia were higher with guadecitabine. In conclusion, no significant difference was observed in the efficacy of guadecitabine and TC in the overall population. This trial was registered at www.clinicaltrials.gov as #NCT02348489.