bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factor analysis for major mediastinal vessel invasion in thymic epithelial tumors based on multi-slice CT Imaging
Authors: Ma Yu-Hui , Zhang Jie , Yan Wei-Qiang , Lan Jiang-Tao , Feng Xiu-Long , Wang Shu-Mei , Yang Guang , Hu Yu-Chuan , Cui Guang-Bin 
Published: September 2023

ObjectiveTo explore the characteristics and risk factors for major mediastinal vessel invasion in different risk grades of thymic epithelial tumors (TETs) based on computed tomography (CT) imaging, and to develop prediction models of major mediastinal artery and vein invasion.MethodsOne hundred and twenty-two TET patients confirmed by histopathological analysis who underwent thorax CT were enrolled in this study. Clinical and CT data were retrospectively reviewed for these patients. According to the abutment degree between the tumor and major mediastinal vessels, the arterial invasion was divided into grade I, II, and III (&lt; 25%, 25 – 49%, and ≥ 50%, respectively); the venous invasion was divided into grade I and II (&lt; 50% and ≥ 50%). The degree of vessel invasion was compared among different defined subtypes or stages of TETs using the chi-square tests. The risk factors associated with TET vascular invasion were identified using multivariate logistic regression analysis.ResultsBased on logistic regression analysis, male patients (β = 1.549; odds ratio, 4.824) and the pericardium or pleural invasion (β = 2.209; odds ratio, 9.110) were independent predictors of 25% artery invasion, and the midline location (β = 2.504; odds ratio, 12.234) and mediastinal lymphadenopathy (β = 2.490; odds ratio, 12.06) were independent predictors of 50% artery invasion. As for 50% venous invasion, the risk factors include midline location (β = 2.303; odds ratio, 10.0), maximum tumor diameter larger than 5.9 cm (β = 4.038; odds ratio, 56.736), and pericardial or pleural effusion (β = 1.460; odds ratio, 4.306). The multivariate logistic model obtained relatively high predicting efficacy, and the area under the curve (AUC), sensitivity, and specificity were 0.944, 84.6%, and 91.7% for predicting 50% artery invasion, and 0.913, 81.8%, and 86.0% for 50% venous invasion in TET patients, respectively.ConclusionSeveral CT features can be used as independent predictors of ≥50% artery or venous invasion. A multivariate logistic regression model based on CT features is helpful in predicting the vascular invasion grades in patients with TET.
Effect of far-infrared therapy device on arteriovenous fistula maturation and lifespan in hemodialysis patients: a randomized controlled clinical trial
Authors: Huang Jianqiang , Zheng Peilan , Chen Xiaobin , Zheng Fan , He Beibei 
Published: September 2023

IntroductionArteriovenous fistula (AVF) is the first choice of vascular access for hemodialysis treatment, and its surgical maturity rate is not high, and its postoperative complications (mostly stenosis) significantly shorten its life. At present, there are few studies on treatment methods to improve the maturity and survival of AVF. In this study, the effect of far infrared therapy (FIR) on the maturity and longevity of arteriovenous fistula in hemodialysis patients was discussed, and the protective mechanism of AVF induced by FIR therapy was explored, aiming at exploring a new treatment method.MethodsThe hemodialysis patients admitted to the 900th Hospital of the Chinese Joint Logistics Support Force of the People's Liberation Army from January 2021 to April 2023 were randomly divided into control group and intervention group, with 40 cases in each group. Among them, the control group was coated with mucopolysaccharide polysulfonate cream; Intervention group: The patients were treated with mucopolysaccharide polysulfonate cream and far infrared radiation at the same time. After 3 months' intervention, the arteriovenous fistula (vein diameter, mature time of arteriovenous fistula, blood flow controlled by pump during dialysis, blood flow of brachial artery during dialysis and the occurrence of complications of internal fistula (oozing, occlusion and infection) and the pain score (numerical rating scale, NRS) of the two groups were compared, and the curative effects were compared.ResultsThere was no significant difference in general data between the two groups (P &gt; 0.05), which indicated that the study was comparable. After 3 months' intervention, the vein diameter, pump-controlled blood flow and brachial artery blood flow in the intervention group were significantly higher than those in the control group (P &lt; 0.05). And the maturity time, NRS score and complication rate of arteriovenous fistula were significantly lower than those of the control group (P &lt; 0.05). The primary patency rate of AVF in the intervention group was higher than that in the control group, and the overall patency rate between the two groups was statistically significant (P &lt; 0.05).ConclusionsAs a promising new treatment method, far infrared therapy can effectively promote the maturity of AVF, increase venous diameter, pump controlled blood flow during dialysis, brachial artery blood flow during dialysis, and prolong the service life of AVF.
Case Report: Abdominal Wall Reconstruction in a High-Risk Patient With Incisional Hernia and Complications From Oncological Treatment
Authors: Silva Thiago Souza , Martins Mario Rino , Batista Thales Lima , Martins Euclides Dias , Fernandes Marcelo Henrique , Hinrichsen Eduarda Araujo 
Published: September 2023

Introduction: A high risk patient with evisceration underwent to abdominal wall reconstruction without mesh or drains. We present a case of a 62 years-old female patient with a significant medical history of Wilson’s disease-related hepatopathy Child-Pugh class B classification, sequelae of a stroke, and relevant surgical background including total hysterectomy, oophorectomy, and Hartmann’s procedure for ovarian neoplasm stage 3. The patient developed a large incisional hernia in the midline incision while undergoing Bevacizumab (Avastin) treatment for clinical oncology. During an attempt at skin closure due to erosion and necrosis, there was progressive deterioration leading to evisceration. We opted for abdominal wall reconstruction by transposing the hernia sac without using mesh and employing hemostatic powder (Arista) to mitigate the risk of bleeding in a high-risk patient due to recent bevacizumab use and hepatopathy. The patient had a favorable postoperative course without any other intervention in abdominal wall. Patient developed worsening hepatic function with the presence of ascites, constipation, and disorientation. On the 6th day postoperative, a tomography was performed, which showed colonic distension without obstructive factors and a slight amount of supra-aponeurotic fluid. The patient was discharged on the 10th day postoperative after improvement of the condition with clinical treatment. The patient has been progressing under outpatient follow-up for 5 months, with a resumption of chemotherapy cycles and no evidence of hernia recurrence.Conclusion: Further studies and long-term follow-up are necessary to evaluate the efficacy and safety of hernia sac transposition as a mesh-free technique and the use of hemostatic powder without drains in high-risk patients. However, our case highlights the potential feasibility of these approaches in carefully selected cases.
Screening of Anti-Inflammatory Activity and Metabolomics Analysis of Endophytic Fungal Extracts; Identification and Characterization of Perylenequinones and Terpenoids from the Interesting Active Alternaria Endophyte
Authors: Spina Rosella , Ropars Armelle , Bouazzi Sihem , Dadi Safa , Lemiere Pascal , Dupire François , Khiralla Afra , Yagi Sakina , Frippiat Jean-Pol , Laurain-Mattar Dominique 
Published: September 2023

Patients suffering from inflammatory chronic diseases are classically treated with anti-inflammatory drugs but unfortunately are highly susceptible to becoming resistant to their treatment. Finding new drugs is therefore crucial and urgent and research on endophytic fungi is a promising way forward. Endophytic fungi are microorganisms that colonize healthy plants and live within their intercellular tissues. They are able to produce a large variety of secondary metabolites while allowing their host to stay healthy. A number of these molecules are endowed with antioxidant or antimicrobial as well as cytotoxic properties, making them very interesting/promising in the field of human therapy. The aim of our study was to investigate whether extracts from five endophytic fungi isolated from plants are endowed with anti-inflammatory activity. Extracts of the endophytic fungi Alternaria alternata from Calotropis procera leaves and Aspergillus terreus from Trigonella foenum-graecum seeds were able to counteract the lipopolysaccharide (LPS) pro-inflammatory effect on THP-1 cells differentiated into macrophages. Moreover, they were able to induce an anti-inflammatory state, rendering them less sensitive to the LPS pro-inflammatory stimulus. Taken together, these results show that these both endophytic fungi could be interesting alternatives to conventional anti-inflammatory drugs. To gain more detailed knowledge of their chemical richness, phytochemical analysis of the ethyl acetate extracts of the five endophytic fungi studied was performed using HPTLC, GC-MS and LC-MS with the Global Natural Products Social (GNPS) platform and the MolNetEnhancer tool. A large family of metabolites (carboxylic acids and derivatives, steroid derivatives, alkaloids, hydroxyanthraquinones, valerolactones and perylenequinones) were detected. The purification of endophytic fungus extract of Alternaria alternate, which diminished TNF-α production of 66% at 20 µg/mL, incubated one hour before LPS addition, led to the characterization of eight pure compounds. These molecules are altertoxins I, II, III, tricycloalternarenes 3a, 1b, 2b, anthranilic acid, and o-acetamidobenzoic acid. In the future, all these pure compounds will be evaluated for their anti-inflammatory activity, while altertoxin II has been shown in the literature as the most active mycotoxin in terms of anti-inflammatory activity.
Vidas clandestinas, historias fragmentadas otra forma de insilio en Uruguay
Authors: Larrobla Caraballo Fabiana , Figueredo Corradi Magdalena 
Published: September 2023

Este artículo explora la experiencia de la clandestinidad política en Uruguay durante los años de dictadura (1973-1985) ubicándola dentro del fenómeno del insilio o exilio interior entendiendo que configura una expresión de las consecuencias vinculadas al control social, vigilancias y producción del terror por parte del Estado. Su inclusión permite ampliar y complejizar conceptualmente las experiencias de los insilios en el entendido de que representó, para quienes la vivieron y sus familias, otra forma de destierro sin salir del territorio de origen.
El mismo se estructura en base a fuentes testimoniales y entrevistas realizadas por las autoras, como forma de acceder al complejo entramado de emociones y sensaciones que se van desplegando al recorrer la memoria.
De esta manera el artículo pretende dar cuenta de las transformaciones profundas en la vida de los militantes que ingresaron a la clandestinidad a partir de las rupturas con los lugares de pertenencia (tanto reales como simbólicos), la interrupción de los vínculos afectivos, el miedo como compañía permanente, la dificultad de dar forma al relato y la fuerte presencia del silencio así como también las construcciones de sentido en torno a la militancia clandestina que permitieron atravesar esta experiencia traumática.
La relegación como mecanismo de represión de la dictadura chilena (1973-1989) y su representación en el cine. El caso de la película “La Frontera” de Ricardo Larraín
Authors: Peñaloza Palma Carla 
Published: September 2023

A partir del 11 de septiembre de 1973, la dictadura chilena y sus servicios represivos, desplegaron una amplia gama de mecanismos de castigo, persecución y control de los opositores políticos.
Una de las características del régimen, es que, aun cuando todos estos métodos estaban reñidos con el Estado de derecho, muchas veces se buscó dar un respaldo administrativo a través de decretos y disposiciones legales, que buscaban dar una apariencia normativa a la represión.
Entre los diversos mecanismos represivos que usó la dictadura para perseguir a sus opositores, recurrió a la relegación de personas a lugares extremos y apartados del país como medida de castigo y aislamiento.
Esta práctica se institucionalizó en 1980, a través de una ley que permitía estos traslados a quienes eran acusados de alterar el orden público, sin necesidad de un proceso judicial. De hecho, fue una medida recurrente contra aquellos dirigentes sociales que convocaron a las jornadas de protesta contra la dictadura entre 1983 y 1986.
A pesar de haber sido aplicada con relativa frecuencia en la década de los ochenta, y en especial afectaba, en general, a dirigentes sociales y políticos conocidos, existen muy pocas investigaciones que aborden el tema.
En contrapartida a su escaso abordaje en el ámbito académico, y en el espacio público en general, la relegación fue visibilizada a través del cine en una de las películas más renombradas de la filmografía nacional, a comienzos de la transición a la democracia, como fue la película "La frontera" (1991) que relata la historia de un profesor, que en su calidad de dirigente gremial es relegado a un pequeño y aislado pueblo del sur de Chile.
La pesca en el Atlántico sur, del Estrecho de Magallanes a la Antártida. Un análisis descriptivo desde 1980 a la actualidad
Authors: López Manuel Isidoro , López García Rebeca Florentina 
Published: September 2023

Este trabajo pretende realizar un análisis descriptivo del desarrollo pesquero en el Atlántico Sur, y, su estado actual, dentro del ámbito jurisdiccional de la Provincia de Tierra del Fuego, Antártida e Islas del Atlántico Sur. A partir de la información bibliográfica y normativa disponible, se realizará un análisis de las distintas pesquerías, desde un enfoque integral. Abordando, cronológicamente, tanto el marco legal, como el contexto político, social y económico en el cual se desarrollan.
El recorte temporal de la investigación estará limitado a los últimos cuarenta años. Se iniciará con la pesca artesanal en las localidades costeras, describiendo características de cada zona, actividades realizadas y dificultades que se presentan para establecer proyectos económicamente sostenibles.
Luego se profundizará en la actividad industrial, realizando una caracterización de la actividad y de las especies objetivo. Mostrando que, la reducción en el tamaño y número de la flota, está asociada al aumento del esfuerzo pesquero. Por otra parte, se deja en evidencia, de que, si bien la explotación con buques factorías genera el mayor volumen de divisas para el país, es una actividad que no genera trabajo en tierra, ni vinculo social, impidiendo la reactivación de la economía local asociada a la pesca.
Overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus, a diagnostic and a management challenge
Authors: Krstevski M. , Janev Olivera Gjeorgjieva , Krstic L. 
Published: September 2023

Thrombotic thrombocytopenic purpura (TTP) is a rare, potentially fatal blood disorder that can be challenging for clinicians to identify in the setting of autoimmune diseases such as systemic lupus erythematosus (SLE). SLE can present with thrombotic microangiopathy (TMA) and differentiation between the two diseases can be quite difficult.
In this case report we present a 62-year-old female with a history of SLE who was hospitalized with thrombocytopenia, dysarthria, dizziness, paresthesia and altered mental status. The laboratory results revealed direct Coombs negative hemolytic anemia, severe thrombocytopenia, significant elevation of lactate dehydrogenase, leukocytosis and presence of few schistocytes in the peripheral film. In addition, we also present evidence for circulating anti-ADAMTS13 antibody/ADAMTS13 antigen. Based on clinical, hematological, and biochemical findings, we concluded that it was a case of TTP-like microangiopathy associated with SLE and indicated treatment with methylprednisolone pulses and plasmapheresis. Later on, she developed psychosis and made plasmapheresis difficult to perform. We continued corticosteroids (dose 1mg/kg), RhoGAM, Chloroquine and Azathioprine, obtaining a satisfactory response after one week of treatment.
Historical Reality Depicted in Early Russian Hagiography
Authors: Конявская Е.Л. 
Published: September 2023

В статье анализируются Жития Феодосия Печерского и Авраамия Смоленского с точки зрения значимости содержащихся в них данных по русской истории — политической, церковной и истории повседневности.
The article is based on the Life of Theodosius of the Caves and the Life of Abraham of Smolensk. Analyzed is the significance of the available political, religious, and everyday historical data.
«I don’t fit abroad…» Investigatory Records on Colonel L.V. Kostandi (1920–1921)
Authors: Ганин А.В. 
Published: September 2023

Материал представляет первую публикацию документов следственного дела пленного белого офицера полковника Л.В. Костанди – видного участника Белого движения на Севере России.
The material represents the first publication of the documents of the investigative case of the captured Colonel of the White Movement, L.V. Kostandi – a prominent participant of the White Movement in North Russia
Bridging Loss-of-Lock in InSAR Time Series of Distributed Scatterers
Authors: Conroy Philip 
Published: September 2023

<p>In this work, we discuss a type of signal loss/decorrelation encountered in InSAR time series analysis which we call “loss-of-lock”, and show how it has significant implications for the use of InSAR in monitoring dynamically changing regions. We show how this otherwise irreparable loss of coherence in InSAR time series’ can be overcome by informing the processing algorithm with contextual data of the region of interest. </p>
DESAFIOS E ESTRATÉGIAS DE APRENDIZAGEM SOBRE COMPETÊNCIAS GERENCIAIS NA ÓTICA DOS DOCENTES DE ENFERMAGEM
Authors: Laura Andrian Leal  , Sílvia Helena Henriques  , Denise Maria Osugui  , Sonia Maria Kalckmann de Macedo  , Luan Gagossian Savóia  , Carolina Cassiano  
Published: September 2023

Introdução: Na sociedade moderna, tem-se cada vez mais, a necessidade de formar enfermeiros competentes e propiciar ferramentas para a edificação de competências gerenciais. Portanto, faz-se relevante uma atuação docente que abarque aspectos profícuos de desenvolvimento dessas competências, bem como instituições de ensino que possibilitem ensejos que também as priorizem. Objetivos: Identificar os principais desafios para os estudantes de enfermagem desenvolverem competências gerenciais e as estratégias de aprendizagem segundo a ótica dos docentes de enfermagem. Métodos: Estudo exploratório de abordagem qualitativa, realizado com 12 docentes vinculados a uma Instituição de Ensino Superior pública brasileira. Os dados foram coletados em 2020 por meio da técnica de grupo focal e analisados de acordo com a análise temática indutiva. Evidencia-se que o estudo foi aprovado pelo comitê de ética em pesquisa da instituição proponente. Resultados: Os resultados mostraram que as competências mais desafiadoras são: comunicação, tomada de decisão, liderança, relacionamento interpessoal e negociação de conflitos; tais competências foram justificáveis em virtuda da imaturidade e inexperiência do aluno. Além disso, também foram ressaltados desafios relacionados ao trabalho do docente, sobretudo quanto à limitação de tempo e sobrecarga. Quanto às estratégias, os docentes evidenciaram: estimulação da iniciativa, raciocínio, empoderamento e autorresponsabilidade do aluno, metodologias ativas de ensino, incluindo simulações e prática de estágio. Conclusões: O método qualitativo permitiu verificar com maior aprofundamento a temática em questão, desvelando as percepções dos docentes de enfermagem. Faz-se necessário que instituições de ensino se atentem para esses fatores com vistas a mitigar as lacunas por meio de estratégias inovadoras e experiências exitosas no ensino de competências gerenciais.
Perfil sociodemográfico e citológico de mulheres em investigação de neoplasia cérvico-uterina em um serviço secundário
Authors: Tavares de Oliveira Jorge Luís , Pinheiro Rodrigues Nádia Cristina , O'dwyer Gisele 
Published: September 2023

Objetivo: analisar o perfil sociodemográfico e comparar as diferenças das características de mulheres com alterações citológicas de alto grau em um serviço da atenção secundária. Método: estudo transversal retrospectivo de 2017 a 2021 realizado em 160 prontuários (CAAE 51800621.3.0000.5240). Resultados: predominaram mulheres com média de idade 40,7 anos, escolaridade abaixo do ensino médio, tiveram um a três filhos, não utilizavam preservativos e anticoncepcionais, não tabagistas e com alterações citopatológicas alto grau. As características com maiores percentuais para lesões citopatológicas de alto grau foram mulheres com quatro ou mais gestações, idade do parto menor ou igual a 18 anos, coitarca menor ou igual a 15 anos e tabagistas. Conclusão: serviços da rede de atenção, especialmente da atenção primária à saúde, devem capacitar permanentemente os profissionais visando cumprimento de fluxos assistenciais preconizadas pelas recomendações das diretrizes brasileiras de rastreamento da neoplasia cérvico-uterina atentando ao perfil encontrado de mulheres encaminhadas a atenção secundária.
Pendampingan Penentuan Harga Pokok Produksi Pesanan pada UMKM Sahabat Ummu Hafidz
Authors: Monoarfa Valentina 
Published: September 2023

Pengabdian ini membahas penentuan harga pokok produksi pesanan dengan penggunaan kartu pesanan, kartu jam kerja, dan kartu persediaan. Dalam menentukan harga pokok produksi pesanan pada UMKM di kecamatan Kabila. Tujuan pengabdian ini adalah untuk memberikan pendampingan penentuan harga pokok produksi pesanan dan cara pembuatan kartu pesanan, kartu jam kerja, dan kartu persediaan. Dalam mengetahui biaya yang diterapkan oleh CV. Ummu Hafidz dalam perhitungan HPP pesanan, Yang mana pada pelaku UMKM ini, belum menerapkan pembuatan kartu pesanan tersebut. Sehingga pelaku UMKM belum efisien dalam menentukan harga jual. Karena perhitungan harga pokok produksi pesanan merupakan hal yang sangat penting dalam menentukan harga jual dari suatu produk. Teknik yang kami gunakan dalam pengumpulan data ini adalah teknik wawancara, observasi, dan dokumentasi.
Smarte Überwachung elektrischer Großantriebe/Smart monitoring large electric drives
Authors: Geisert Claudio , Polte Julian , Uhlmann Eckart , Rauch Hartmut , Brach Karsten 
Published: September 2023

Die Nutzung von Digitalisierungstechnologien im Kontext von Industrie 4.0 bietet insbesondere für den gesamten Bereich der Wartung und Instandhaltung von elektrischen Großantrieben großes Potenzial zur Schaffung innovativer Serviceangebote. Durch erweiterte Sensorik im elektrischen Antrieb und Intelligenz in der Verarbeitung und Analyse von Daten im Betrieb von Anlagen, kann eine vorausschauende Instandhaltungsstrategie eingeführt werden, die eine höhere Verfügbarkeit der Anlagen ermöglicht und gleichzeitig den Aufwand für Instandhaltungseinsätze reduziert. Um diese Potenziale im Servicegeschäft elektrischer Großantriebe zu erschließen, wird in diesem Beitrag ein hypothesengetriebener Ansatz zur Zustandsüberwachung beschrieben.

The use of digitization technologies in the context of Industry 4.0 offers great potential for creating innovative service offerings, particularly for the entire area of the maintenance and servicing of large electrical drives. Advanced sensor technology in the electric drive and intelligence in the processing and analysis of data in the operation of plants can be used to introduce a predictive maintenance strategy that enables higher availability of the plants and at the same time reduces the cost of maintenance operations. To unlock this potential in the service business of large electrical drives, the following paper describes a hypothesis-driven approach to condition monitoring.