bluuebunny/crossref_metadata_2025_split huggingface dataset:
FORMULASI DAN EVALUASI EKSTRAK KULIT BATANG SECANG (Caesalpinia sappan L) SEBAGAI PEWARNA PADA SEDIAAN BLUSH ON GEL PATI KENTANG (Amylum solanni L)
Authors: Hanawara Neta 
Published: January 2023

Blush on adalah jenis kosmetika dekoratif yang dapat digunakan untuk meningkatkan estetika dalam tata rias wajah. Tujuan penelitian ini adalah untuk memformulasi dan evaluasi sediaan blush on dalam bentuk semi padat menggunakan pati kentang sebagai gelling agent dan kulit batang secang sebagai pewarna. Kulit kayu secang yang mengandung pigmen braizilin,brailien dan senyawa flavonoid yaitu antosianin dalam jumlah yang besar sebagai pewarna. Pati kentang yang digunakan sebagai gelling agent memiliki nilai swelling power dan viskositas tinggi dibandingkan dengan pati lainnya. Pada formulasi konsentasi ekstrak kulit batang secang dibagi dalam 3 formula 1%, 3%, dan 6%. Tiap formula dilakukan pengujian selama 4 minggu pengujian yang dilakukan meliputi organleptik, homogenitas, pH, daya sebar, viskositas, , freeze thaw. Dari data hasil penelitian pada evaluasi sediaan blush on gel menunjukan stabilitas fisik blush on gel tidak mengalami perubah pada uji organoleptik, homogen tidak terdapat gumpalan, memiliki daya sebar 5 – 7,9 cm, pH yang dihasilkan 6,38 – 6,89, viskositas 2131 – 3029 cPs dan tidak terjadi pemisahan fase. Berdasarkan hasil yang diperoleh dapat disimpulkan ekstrak kulit batang secang dapat digunakan sebagai pewarna alam pada sediaan kosmetik.
Artikel Text FORMULASI DAN EVALUASI SEDIAAN PEWARNA RAMBUT EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus Polyrhizus)
Authors: Farhanah Aulia 
Published: January 2023

Salah satu jenis sediaan kosmetik yang digemari adalah pewarna rambut. Sediaan pewarna rambut adalah sediaan kosmetika yang digunakan dalam tata rias rambut untuk mewarnai rambut asalnya atau dengan warna lain. Tujuan penelitian ini ialah untuk memformulasi dan evaluasi sediaan pewarna rambut ekstrak kulit buah naga sebagai pewarna. Kulit buah naga memiliki unsur senyawa pewarna alami yang tinggi atau yang disebut antosianin, selain itu juga mengandung vitamin E yang tinggi, Vitamin C, Vitamin A. Pada formulasi konsentrasi ektrak kulit buah naga dibagi menjadi 3 formula yaitu F1= 8%, F2 = 10%, dan F3 = 12%. Evaluasi yang dilakukan pada penelitian ini berupa pengujian organoleptik yang dinilai oleh dosen ahli dan pegujian pH. Hasil dari uji organoleptik ialah mendapatkan hasil kestabilan yang baik serta penelitian sediaan ini menghasilkan warna rambut dari merah tua hingga merah gelap. Penelitian ini menunjukan bahwa konsentrasi yang menghasilkan warna terbaik ialah formula 2 yang menghasilkan warna merah keungu-unguan pada rambut. Dan pada uji pH menunjukan angka 4,5-5,0 sesuai dengan pH kulit rambut normal, berdasarkan hasil uji tersebut sediaan pewarna rambut ekstak kulit buah naga merah (Hylocereus Polyrizhus) aman digunakan dan dapat disimpulkan bahwa ekstrak kulit buah naga merah dapat digunakan sebagai pewarna alami pada sediaan kosmetik.
HUBUNGAN LINGKUNGAN KELUARGA DAN MOTIVASI BELAJAR LIFE SKILL (TATA RIAS) SISWA SMP TERBUKA CAKUNG 1 JAKARTA TIMUR
Authors: Rahma Adiharsinta  
Published: January 2023

ABSTRAK
Lingkungan keluarga merupakan lembaga pendidikan pertama dan utama. Terdapat faktor yang berpengaruh pada belajar siswa di lingkungan keluarga ialah: (1) Cara orang tua mendidik, (2) Suasana rumah, (3) Keadaan ekonomi keluarga, (4) Pengertian orang tua terhadap anak. Perbedaan pendapatan keluarga dapat berpengaruh pada fasilitas dan prasarana belajar anak. Life skill Tata Rias memiliki peran penting dalam rangka membekali peserta didik agar dapat hidup secara mandiri. Hal ini bermaksud dapat memberi peluang mengetahui bakat minat siswa dan diharapkan dapat berguna apabila siswa harus terjun langsung ke dunia usaha, karena siswa memiliki pengalaman dan menguasai kompetensi produktif. Penelitian ini bertujuan unntuk mengetahui seberapa besar hubungan antara lingkungan keluarga dengan motivasi belajar life skill Tata Rias siswa SMP Terbuka Cakung 1 Jakarta Timur.
Penelitian ini merupakan penelitian korelasional dengan metode survei. Hasil penelitian ini menunjukan bahwa terdapat pengaruh positif lingkungan keluarga (X) terhadap motivasi belajar (Y) yang ditunjukkan dengan nilai koefisien korelasi (r) sebesar 0,633. Korefisien determinasi (R2) pada penelitian ini memnunjukkkan besar pengaruh lingkungan keluarga (X) terhadap motivasi belajar (Y) sebesat 40,1% dan sisanya sejumlah 59,9% dipengaruhi oleh faktor lain yang tidak diteliti oleh peneliti. Dengan perhitungan regresi linear sederhana diperoleh nilai koefisien regresi lingkungan keluarga (X) terhadap motivasi belajar (Y) sebesar 10,392 yang berarti setiap peningkatn lingkungan keluarga sebesar 1, maka motivasi belajar siswa akan meningkatkan sebesar 10,392. Dengan persamaan regresi dapat ditulis Y = 11.392 + 10.172X.
Kata Kunci: Motivasi Belajar, Lingkungan Keluarga, Life Skill, Tata Rias
Minat Beli Serum Bulu Mata Melalui Media Sosial Instagram
Authors: Erfina Nurfitria Rifani  , Ambarwati Neneng Siti Silfi 
Published: January 2023

ABSTRACT
ERFINA NURFITRIA RIFANI. Interest in Buying Eyelash Serum via Instagram Social Media. Jakarta. Diploma Three Makeup Study Program, Faculty of Engineering, Jakarta State University, 2021.
This study aims to found out how interest in buying eyelash serum through social media for students of the D3 Makeup Program 2019 Jakarta State University. This research was made using quantitative descriptive methods by distributing questionnaires to students of the D3 Makeup program 2019 at Jakarta State University. Based on theoretical studies and data collection conducted in this study, itu produces 81,11%.
Emerging Minimally Invasive Percutaneous Procedures for Periacetabular Osteolytic Metastases
Authors: Ibe Izuchukwu , Dussik Christopher M. , Callan Alexandra K. , Barr Jennifer , Lee Francis Y. 
Published: January 2023

➤ Periacetabular osteolytic skeletal metastases are frequently associated with pain and impaired ambulatory function. Minimally invasive techniques allow for the restoration of ambulation without interrupting critical systemic cancer therapy.➤ The open surgical management of massive periacetabular osteolytic lesions, such as by curettage, internal fixation, or complex total hip reconstruction, is associated with blood loss, hospitalization, rehabilitation, and complications such as infection or delayed wound-healing.➤ Minimally invasive percutaneous procedures have become increasingly popular for the management of periacetabular osteolytic metastases by interventional oncologists and orthopaedic surgeons before complex open surgical procedures are considered.➤ Minimally invasive procedures may include various methods of cancer ablation and reinforcement techniques. Minimally invasive procedures may entail cancer ablation, polymethylmethacrylate (PMMA) cement reinforcement, balloon osteoplasty, percutaneous screw fixation, or combinations of the aforementioned techniques (e.g., ablation-osteoplasty-reinforcement-internal fixation [AORIF]).
Precambrian–Cambrian Transition at the Igarka Uplift (Northwestern Siberian Platform)
Authors: Marusin V.V. , Kochnev B.B. , Karlova G.A. , Izokh O.P. , Sarsembaev Zh.A. , Ivanova N.A. 
Published: January 2023

Abstract
—The Precambrian–Cambrian transition is one of the most fundamental evolutionary turnovers in the Earth’s history. However, in many cases precise identification and correlation of this crucial boundary in lithologically contrasting sections is complicated, even if the whole spectrum of biostratigraphic and chemostratigraphic methods is applied. The Precambrian–Cambrian transitional strata of the Igarka Uplift (Sukharikha Formation) perfectly illustrate this problem. This unit has arguably one of the most detailed carbonate carbon isotope curves for this time interval (at least within the Siberian Platform). However, an extremely poor paleontological record previously reported from the Sukharikha Formation makes identification of major stratigraphic boundaries highly debatable. We present a detailed study of the Sukharikha and overlying Krasnyi Porog formations in three sections (Sukharikha River, Kulyumbe River, and Khantaisko-Sukhotungusskaya-1 well). Our chemostratigraphic and biostratigraphic data provide a correlation basis for these sections and identify the Cambrian boundary in terms of both the International Chronostratigraphic Chart and General Stratigraphic Scale of Russia. We show that lithologic boundaries and levels of the local first appearance of Tommotian small skeletal fossils are diachronous within the Igarka paleobasin. The latter is putatively caused by paleoecology of the early Cambrian biota and by taphonomic factors. Our data specify the location of the Tommotian Stage (sensu lato)/Cambrian Stage 2 boundary in other key Precambrian–Cambrian transitional sections of the Siberian Platform.
"One -step method" laparoscopic bile tube detection+laparoscopic cholecystectomy treatment
Meta analysis of gallbladder stones with gallbladder chassis stones
Authors: Ding Wei , Yan Sheng 
Published: January 2023

Abstract
Objective
Analyze the "one -step method" laparoscopic biliary tube detection (LCBDE) combined with laparoscopic gallbladder sinking (LC) to treat the effects and safety of gallbladder stones with bile stones (CBDS).
Methods
Retrieve Chinese and English databases, collect LCBDE combined with LC to treat gallbladder stones with clinical random control research (RCT). Essence The ending indicators include CBD clearing stones, transit opening rates, stones residual rates, stones recurrence rates, postoperative complications, and postoperative hospitalization.
Results
This study has been included in 21 documents. Two groups of CBD Qingshi (OR = 0.78, 95%CI: 0.49, 1.25), stones residue rate (or = 0.73, 95%CI: 0.34, 1.56) There is no statistical difference. The recurrence rate of "one -step method" is significantly lower than the "two -step method" (or = 0.37, 95%CI: 0.20, 0.69), the total incidence of complications was significantly lower (or = 0.66, 95%CI: 0.52, 0.84), shorter after surgery (WMD =−1.07D, 95%CI:−2.00,−0.14).
Conclusion
The "one -step method" LCBDE combined with LC treatment of gallbladder stones and CBDS effects are equivalent to ERCP/EST sequential LC, but their postoperative complications have fewer complications. Patients recovery after surgery are a more ideal choice.
Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis
Authors: Lavine Kory , Amrute Junedh , Luo Xin , Penna Vinay , Bredemeyer Andrea , Yamawaki Tracy , Yang Steven , Kadyrov Farid , Heo Gyu , Shi Sally , Lee Paul , Koenig Andrew , Kuppe Christoph , Jones Cameran , Kopecky Benjamin , Hayat Sikander , Ma Pan , Terada Yuriko , Fu Angela , Furtado Milena , Kreisel Daniel , Stitziel Nathan , Li Chi-Ming , Kramann Rafael , Liu Yongjian , Ason Brandon 
Published: January 2023

Abstract

Inflammation and tissue fibrosis co-exist and are causally linked to organ dysfunction. However, the molecular mechanisms driving immune-fibroblast crosstalk in human cardiac disease remains unexplored and there are currently no therapeutics to target fibrosis. Here, we performed multi-omic single-cell gene expression, epitope mapping, and chromatin accessibility profiling in 38 donors, acutely infarcted, and chronically failing human hearts. We identified a disease-associated fibroblast trajectory marked by cell surface expression of fibroblast activator protein (FAP), which diverged into distinct myofibroblasts and pro-fibrotic fibroblast populations, the latter resembling matrifibrocytes. Pro-fibrotic fibroblasts were transcriptionally similar to cancer associated fibroblasts and expressed high levels of collagens and periostin (POSTN), thymocyte differentiation antigen 1 (THY-1), and endothelin receptor A (EDNRA) predicted to be driven by a RUNX1 gene regulatory network. We assessed the applicability of experimental systems to model tissue fibrosis and demonstrated that 3 different in vivo mouse models of cardiac injury were superior compared to cultured human heart and dermal fibroblasts in recapitulating the human disease phenotype. Ligand-receptor analysis and spatial transcriptomics predicted that interactions between C-C chemokine receptor type 2 (CCR2) macrophages and fibroblasts mediated by interleukin 1 beta (IL-1β) signaling drove the emergence of pro-fibrotic fibroblasts within spatially defined niches. This concept was validated through in silico transcription factor perturbation and in vivo inhibition of IL-1β signaling in fibroblasts where we observed reduced pro-fibrotic fibroblasts, preferential differentiation of fibroblasts towards myofibroblasts, and reduced cardiac fibrosis. Herein, we show a subset of macrophages signal to fibroblasts via IL-1β and rewire their gene regulatory network and differentiation trajectory towards a pro-fibrotic fibroblast phenotype. These findings highlight the broader therapeutic potential of targeting inflammation to treat tissue fibrosis and restore organ function.
Bioactive multi-protein adsorption enables targeted mast cell nanotherapy
Authors: Du Fanfan , Rische Clayton , Li Yang , Vincent Michael , Krier-Burris Rebecca , Qian Yuan , Yuk Simseok , Almunif Sultan , Bochner Bruce , Qiao Baofu , Scott Evan 
Published: January 2023

Abstract
Proteins readily and often irreversibly adsorb to nanomaterial surfaces, resulting in denaturation and loss of bioactivity1,2. Controlling this process to preserve protein structure and function has remained an elusive goal that would enhance the fabrication and biocompatibility of protein-based bioactive nanomaterials3-7. Here, we demonstrate that poly(propylene sulfone) (PPSU)8 nanoparticles support the controlled formation of multi-component enzyme and antibody coatings while maintaining their bioactivity. Simulations indicate that hydrophobic patches9 on protein surfaces induce site-specific dipole relaxation on PPSU surfaces to noncovalently anchor proteins without disrupting hydrogen bonding or protein structure. As proof-of-concept, a nanotherapy for enhanced antibody-based targeting of mast cells and inhibition of anaphylaxis3,4 is demonstrated in a humanized mouse model. The ratio of co-adsorbed anti-Siglec-610,11 and anti-FcεRIα antibodies is systematically optimized to effectively inhibit mast cell activation and degranulation. Protein immobilization on PPSU surfaces therefore provides a simple and rapid platform for the development of targeted nanomedicines.
An Optical Logic Gate Based On 2-Dimensional Photonic Crystals with High Operating Contrast Ratio And Fast Response Time
Authors: DERDOUR ROUMAISSA , Lebbal Mohamed Redha , Mouetsi Souheil 
Published: January 2023

Abstract
An optimized all-optical "NAND" logic gate is studied analytically. The particular characteristic of this logic gate is that it is based on photonic crystals, it consists of a resonator coupled with two waveguides on a silicon substrate. The operating wavelength is equal to 1.55µm which represents the telecommunication wavelength, the switching power of the optical logic gate studied is 1.693 kw /µm2 its response is independent of the response of the resonator when the power intensity of the optical waves is lower than the resonance wavelength, the light will be coupled in the waveguides, in the opposite case the light propagates in the waveguide of the bus.
Serum zinc in patients with colorectal cancer might contribute to the prediction of tumor clinical staging scores： a prospective single-center clinical study
Authors: Zhang Chenlong , Zhang Yumei , Wang Yujie , Guo Kaihang , Li Pengfei , Zhang Chunfang , An Hanxiang , Huang Lairong 
Published: January 2023

Abstract
Background: Diagnosis for colorectal cancer is infrequently diagnosed and not accurate staging. Trace elements may be involved in the whole process of intestinal tumors. Can trace elements be used to predict condition and staging scores for colorectal cancer?
Methods: Patients(n=74) and the control group (n=32) were enrolled. Data from the first acceptance were recorded including age, gender, clinical staging scores of tumors, and tumor biomarkers. The serological specimens were tested for magnesium, iron, copper, zinc, calcium, and selenium with ICP-MS. T-test was used to analyze serum trace elements in patients and the control group, and LASSO regression was executed to screen which factors contributed most to clinical staging scores.
Results: The level of copper in the control group is lower than in the patients (p=0.0004, ∆mean±SEM=210.7±57.79, and 95%CI=96.14to325.4). For the other five trace elements in the control group is higher than in the patients, respectively manganese (p=0.0003, ∆ mean±SEM=-1.658±0.4470, 95%CI=-2.544to-0.7713), iron (p=0.0343, ∆ mean=-0.3672±0.1712, 95%CI=-0.7068to-0.02761), zinc (p=0.0059, ∆ mean=-0.1348±0.04794, 95%CI=-0.2298to-0.03968), calcium (p<0.0001, ∆ mean=-15.10±3.482, 95%CI=-22.00to-8.195), selenium (p=0.0216, ∆mean=-12.23±5.242, 95%CI=-22.62to-1.832). The results of LASSO regression show variables selected are Ca125 （ coefficient=5.8e-04 ） , Ca199 （coefficient=7.4e-05）, zinc（coefficient=-0.2047） ， and intercept（3.1951）, which are regarded as the most contributing to the clinical staging scores， the coefficients for other factors are zero.
Conclusions: Ca125 and Ca199 are positively contributing to the clinical staging scores, and zinc is negatively correlated with them. Therefore, we suggest that serum zinc might be used to predict the clinical staging scores of patients with colorectal cancer.
Native microbiome dominates over host factors in shaping the probiotic genetic evolution in the gut
Authors: Jiang Shuaiming , Zhang Chengcheng , Han Zhe , Ma Wenyao , Wang Shunhe , Huo Dongxue , Cui Weipeng , Zhai Qixiao , Huang Shi , Zhang Jiachao 
Published: January 2023

Abstract
Probiotics often acquire adaptive mutations in vivo gaining new functional traits through gut selection. However, it remains challenging to separate microbiome and host contribution to such selective pressures. Here, we tracked and compared the temporal genetic evolution of representative probiotic strains in germ-free (GF) and specific-pathogen-free (SPF) mice. Notably, host only elicited < 15 probiotic mutations, < 0.25% of those derived from both factors that was never captured by other experimental evolution studies, indicating that keen microbial competitions exhibited the predominant evolutionary force in shaping probiotic genetic composition (> 99.75%). Furthermore, native microbiome consistently drove a more rapid and divergent genetic evolution of probiotic strains in seven days of colonization than host factors did. Our study further laid a theoretical foundation for genetically engineering probiotics for better gut adaptation through in vitro artificial gut ecosystems without the selection pressures derived from host factors.
The Church in the Face of the Challenges of the Post-Pandemic Era
Authors: Wyszowadzki Władysław 
Published: January 2023

The purpose of the research is to analyze the situation of the Church and pastoral care in the post-pandemic reality. The experience of the 2020-2022 period shows that there has been a strengthening of the faith attitudes of Catholics actively participating in the life of the Church. At the same time, the weaker sides of pastoral care, resulting from a confrontation with the media world, have shown themselves. This calls for using the experience of people of science, medicine, bioethics, and psychology in the pastoral model. Pastoral activity should also value sacramental pastoral care with the Eucharist at the center. New challenges also face pastoral theology, whose research results can be used to seek new ways of carrying out salvific mission and evangelization.
Construcción de algoritmos como estrategia de aprendizaje en medicina
Authors: Pérez Romero Fernando René 
Published: January 2023

Introducción: Los algoritmos están en casi todos los procesos de interacción y coordinación para completar tareas físicas y mentales exigentes a futuro, suponiendo en medicina, el paso de los algoritmos biológicos a los artificiales con eliminación del error y un manejo óptimo de la información con mayor beneficio para el humano.
Objetivo: Determinar la percepción de la utilidad en la aplicación de la teoría de algoritmos para la solución a problemas clínicos mediante la aplicación del razonamiento algorítmico.
Material y método: Para evaluar la percepción de la aplicación de la teoría de algoritmos en la solución a problemas clínicos, teóricos y reales, se exploró la percepción de la utilidad de la teoría de algoritmos en estudiantes de la carrera de medicina, mediante la aplicación de encuestas previas y posteriores a una intervención educativa.
Resultados: Posterior a la intervención, la percepción de los estudiantes es que la mayoría (más del 70%) considera que los algoritmos son indispensables para los médicos, que su uso es evidente en la literatura médica y que es necesario tener un conocimiento profundo del tema a tratar. En cuanto a la utilidad para el aprendizaje, la mayoría (más del 60%) considera que sirven para describir o recordar un tema, para explicar o resumir, y para organizar y establecer soluciones a un problema. Las opiniones del estudiantado fueron predominantemente positivas para la utilidad de los algoritmos.
Conclusión: La teoría de algoritmos proporciona una alternativa metodológica de aprendizaje, pues se integran distintas áreas del conocimiento médico, proporcionando una o varias vías de solución, que ayudan a la descripción o explicación de la patología, o para su aplicación en un contexto real de atención al paciente.
La aplicación electrónica “MedAPProc” para la evaluación formativa en el internado médico
Authors: Vives Varela Tania , Hamui Sutton Liz 
Published: January 2023

Uno de los mayores retos de las universidades formadoras de médicos es repensar, investigar y adaptar las tecnologías para el aprendizaje y el conocimiento a procesos de comunicación empática, intercambio social, cultural, profesional y de armonía emocional para los actores universitarios. La evaluación del nivel de logro de las competencias que los médicos requieren alcanzar es una tarea fundamental en el proceso de formación de los mismos. Los celulares y tabletas electrónicas, brindan un gran número de posibilidades para incorporar nuevas formas de evaluación y registro de información durante el desarrollo de las competencias de los estudiantes.
En el marco de las evaluaciones por medio de las Actividades Profesionales Confiables, la implementación de las aplicaciones móviles (App) para capturar los datos y para ofrecer retroalimentación a los evaluados es cada día mayor. Se han realizado estudios para identificar los aciertos y las barreras en la incorporación de las App para evaluar las APROC. El propósito de este artículo es describir cómo se incorporaron las tecnologías para el aprendizaje y el conocimiento (TAC) en la implementación de una aplicación electrónica “MedAPProc” para la evaluación formativa por medio de Actividades Profesionales Confiables en el internado médico de la Licenciatura de Médico Cirujano de la Facultad de Medicina de la Universidad Nacional Autónoma de México. Se relatan las necesidades, ventajas y limitaciones de migrar del papel hacia los formatos electrónicos para mejorar y hacer más eficiente la evaluación del desempeño de las competencias de los estudiantes.