bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex‐dependent clinical presentation, body image, and endocrine status in long‐term remitted anorexia nervosa
Authors: Schloesser Louisa , Lotter Leon D. , Offermann Jan , Borucki Katrin , Biemann Ronald , Seitz Jochen , Konrad Kerstin , Herpertz‐Dahlmann Beate 
Published: June 2023

AbstractObjectiveAlthough anorexia nervosa (AN) in males has recently gained attention, knowledge of its psychological and physiological outcomes is still scarce. We explore sex‐specific characteristics of long‐term remitted AN with respect to residual eating disorder (ED) psychopathology, body image, and endocrinology.MethodWe recruited 33 patients with AN in remission for at least 18 months (24 women, 9 men) and 36 matched healthy controls (HCs). Eating disorder psychopathology and body image ideals were assessed via clinical interviews, questionnaires, and an interactive 3D body morphing tool. Plasma levels of leptin, free triiodothyronine, cortisol, and sex hormones were quantified. Univariate models controlled for age and weight were used to test for the effects of diagnosis and sex.ResultsBoth patient groups showed residual ED psychopathology but normal weight and hormone levels relative to HCs. Male remitted patients demonstrated significantly stronger muscularity‐focused body image ideals, evident in interviews, self‐reports, and behavioural data, than both female patients and HCs.ConclusionsSex‐specific body image characteristics in patients with remitted AN point towards the need to adjust test instruments and diagnostic criteria to male‐specific psychopathology. In the future, sufficiently powered studies should evaluate the risk of men with AN developing muscle dysmorphia in the long term.
Performance and energy loss mechanism of bifacial photovoltaic modules at a solar carport system
Authors: Hwang Sungho , Kang Yoonmook , Lee Hae‐seok 
Published: June 2023

AbstractAs photovoltaic modules are increasingly used in renewable energy systems, ensuring energy efficiency by reducing the levelized cost of electricity has become the focus of current research. Herein, the 1‐year performances of both monofacial and bifacial photovoltaic modules were monitored, compared, and analyzed at a solar carport system in the Korean peninsula. The environmental parameters during the four seasons were investigated for both systems under ambient conditions. Irradiance was determined as the primary influencing parameter in the system. The energy yield of the bifacial module system was 3.08% higher than that of the monofacial system owing to rear‐side absorption during the study period. The loss mechanism for this lower yield was determined by investigating the irradiance effect. It was attributed to low bifaciality due to cell properties (optical and electrical properties, and the sorting effect) and module properties (shading effects from the junction box cable and frame design, and glass grid effect), design of the carport system, and the albedo effect. These analyses revealed that the photovoltaic energy yield can be increased further by reducing these loss parameters at the carport system. This study can contribute to achieving higher energy yield from photovoltaic systems during field applications.
Material design and performance of carbon monoxide‐fueled solid oxide fuel cells: A review
Authors: Zhang Wei , Hu Yun Hang 
Published: June 2023

AbstractSolid oxide fuel cells (SOFCs) are electrochemical energy conversion devices with fuel flexibility. Since carbon monoxide (CO) is a major product of SOFC anodes operating with hydrocarbon fuels, direct utilization of CO as a fuel is expected for more efficient operation of SOFCs. A review on CO‐fueled SOFC technologies is imperative to promote research activities in this important field, but it has not been published. In this review, we summarize and comment on literatures in this field, with respect to (1) materials developed for three fundamental components (anode, cathode, and electrolyte), (2) power output and stabilization strategies, and (3) critical challenges and directions in the development of CO‐fueled SOFCs.
Experimental and thermal‐structure coupling analysis for oil and water‐swellable packer
Authors: Huang Xin , Xu Tao , Liu Yang 
Published: June 2023

AbstractIt has been widely acknowledged that traditional packers will lose their elastic performance in the context of long periods of operation due to plastic deformation. This paper will introduce a swellable packer that can reduce the failure cases of production effectively. The deformation of the packer rubber in different media and temperatures has been analyzed. The pressure test of several packer rubber under different media is carried out in this paper. The reasonable expansion clearance between the rubber tube and the well wall is obtained by strength calculation to ensure the sealing reliability of the packer. Finally, the thermomechanical coupling calculation of the packer with different structural sizes is carried out. Experiments at different temperatures show that the higher saline concentration is associated with a lower expansion rate and a larger expansion rate in clear water. At the same time, the expansion of volume in clear water increases. In addition, the higher the external temperature is, the larger the temperature gradient is. When the temperature of the outer ring is between 100°C and 140°C, the internal temperature rises to 37°C under the thermomechanical coupling effect.
Assessment of water absorption characteristics for improved sesame (Sesamum indicum L.) varieties during hydration
Authors: Gojiya Devanand , Gohil Vanraj , Dabhi Mukesh , Dhamsaniya Navnitkumar 
Published: June 2023

AbstractThe water absorption characteristics of sesame varieties (GT‐3, GT‐4, GJT‐5, GT‐6, and TKG‐22) were studied during hydration at temperatures ranging 35–55°C. The Peleg model adequately defined the hydration behavior of sesame seed varieties at the 35°C, 45°C, and 55°C soaking temperatures with the comparable coefficient of determination (R2) and mean relative percentage deviation modulus (P). The Peleg rate constant K1 and the capacity constant K2 reduced significantly with the rise in hydration temperatures, suggesting corresponding increases in the initial hydration rate as well as the equilibrium moisture content in all the varieties tested. The Arrhenius equation was used to calculate the activation energy (Ea) of GT‐3, GT‐4, GJT‐5, GT‐6, and TKG‐22 sesame varieties and was noted to be 38.74, 33.37, 30.68, 37.85, and 33.23 kJ/mol, respectively. The enthalpy (H) was raised significantly with hydration temperature while entropy (ΔS) and released energy (ΔG) were found nonsignificant (p > 0.05).
Improved prediction of glioma‐related aphasia by diffusion MRI metrics, machine learning, and automated fiber bundle segmentation
Authors: Shams Boshra , Reisch Klara , Vajkoczy Peter , Lippert Christoph , Picht Thomas , Fekonja Lucius S. 
Published: June 2023

AbstractWhite matter impairments caused by gliomas can lead to functional disorders. In this study, we predicted aphasia in patients with gliomas infiltrating the language network using machine learning methods. We included 78 patients with left‐hemispheric perisylvian gliomas. Aphasia was graded preoperatively using the Aachen aphasia test (AAT). Subsequently, we created bundle segmentations based on automatically generated tract orientation mappings using TractSeg. To prepare the input for the support vector machine (SVM), we first preselected aphasia‐related fiber bundles based on the associations between relative tract volumes and AAT subtests. In addition, diffusion magnetic resonance imaging (dMRI)‐based metrics [axial diffusivity (AD), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and radial diffusivity (RD)] were extracted within the fiber bundles' masks with their mean, standard deviation, kurtosis, and skewness values. Our model consisted of random forest‐based feature selection followed by an SVM. The best model performance achieved 81% accuracy (specificity = 85%, sensitivity = 73%, and AUC = 85%) using dMRI‐based features, demographics, tumor WHO grade, tumor location, and relative tract volumes. The most effective features resulted from the arcuate fasciculus (AF), middle longitudinal fasciculus (MLF), and inferior fronto‐occipital fasciculus (IFOF). The most effective dMRI‐based metrics were FA, ADC, and AD. We achieved a prediction of aphasia using dMRI‐based features and demonstrated that AF, IFOF, and MLF were the most important fiber bundles for predicting aphasia in this cohort.
ESG disclosure and financial performance of multinational enterprises: The moderating effect of board standing committees
Authors: Elmghaamez Ibrahim Khalifa , Nwachukwu Jacinta , Ntim Collins G. 
Published: June 2023

AbstractThe study examines the impact of board committee indexes on the relationship between Environmental, Social, and Governance (ESG) disclosure, and accounting‐ and market‐based performance measures of multinational enterprises (MNEs). Using quantile regression analysis and a large balanced panel data of 500 multinational companies operating in 40 countries from 2009 to 2019 (i.e., 5500 firm‐year observations), we uncovered the following significant associations: (i) a positive relationship between ESG disclosure and accounting performance indicators for large‐sized MNEs, but this relationship is counteracted by the negative influence of the audit and sustainability committee indexes; (ii) the association between market‐based performance outcomes and ESG disclosure is positively affected by the compensation, nomination, and sustainability committee indexes, while it is negatively influenced by the audit committee index; (iii) the combined board committee index has varying impacts on the connection between the components of ESG disclosure, and accounting and market‐relevant performance metrics for different sizes of MNEs; and (iv) while the audit and sustainability committee indexes exert negative effects on the relationship between the components of ESG disclosure and performance measures, these effects are countered by the positive moderating impacts of the compensation and nomination committee indexes. The study concludes by discussing the policy implications of these results.
Treatment effects of laparoscopy versus laparotomy on heterotopic pregnancy after in vitro fertilization and embryo transfer
Authors: Chen Xijing , Chen Feng , Zhu Wenting , Mao Luna , Lv Pingping , Zhu Yimin 
Published: June 2023

AbstractObjectiveTo compare the treatment effects of laparoscopy versus laparotomy on heterotopic pregnancy (HP) after in vitro fertilization‐embryo transfer (IVF‐ET).MethodsThe retrospective case–control study enrolled 109 patients diagnosed with HP after IVF‐ET treatment in our hospital from January 2009 to March 2020. All patients received surgical treatment by either laparoscopy or laparotomy. Data for general characteristics, diagnostic features, surgical parameters, as well as perinatal and neonatal outcomes were collected.ResultsSixty‐two patients received laparoscopy and 47 received laparotomy. Significantly lower percentage of large hemoperitoneum (P = 0.001), shorter surgery duration (P < 0.001), less intraoperative blood loss (P = 0.001), higher rates of general anesthesia (P < 0.001), and lower cesarean section rates for singletons (P = 0.003) were found in the laparoscopy group. The perinatal and neonatal outcomes were comparable between the two groups. When interstitial pregnancy was considered alone, the surgical blood loss was significantly reduced in the laparoscopy group (P = 0.021), but there was no significant difference in hemoperitoneum, surgery duration, or perinatal and neonatal outcomes in singletons.ConclusionBoth laparoscopy and laparotomy are effective surgical treatments for HP after IVF‐ET. Laparoscopy is minimally invasive but laparotomy can be an alternative in emergency situations.
Comparison of Diabetes in Pregnancy Study Group India (DIPSI) and WHO criteria for diagnosis of gestational diabetes by assessment of fetomaternal outcomes
Authors: Raghav Mansvi , Suri Jyotsna , Rani Anita , Debata Pradeep , Bachani Sumitra 
Published: June 2023

AbstractObjectiveTo evaluate fetomaternal outcomes in women who are normoglycemic by Diabetes in Pregnancy Study Group India (DIPSI) but have gestational diabetes mellitus (GDM) by WHO criteria versus those who are normoglycemic by both DIPSI and WHO criteria.MethodsThis was a prospective, cohort study. A total of 635 women participated. They underwent a 2‐h non‐fasting oral glucose tolerance test (OGTT) and results were interpreted by DIPSI. Out of 635 women, 52 were lost to follow up and 33 were diagnosed as GDM by DIPSI and excluded from the study. The remaining 550 women, after 72 h from the first test, underwent a 75‐g fasting‐OGTT and results were interpreted using WHO 2013 criteria. Results of the second test were blinded till delivery. The 550 women were followed for fetomaternal outcomes. Participants with normal DIPSI and normal WHO 2013 OGTT were labeled group 1. Participants with normal DIPSI but abnormal WHO 2013 OGTT were labeled group 2. Fetomaternal outcomes were compared between these groups.ResultsOccurrence of GDM by DIPSI was 5.1%, by WHO 2013 criteria it was 10.5%. Composite fetomaternal outcomes occurred more commonly in women with a normal DIPSI but an abnormal WHO 2013 test. Out of 550 women, 492 had normal DIPSI and normal WHO 2013 test. Out of this 492, 116 (23.6%) women had adverse fetomaternal outcomes. Fifty‐eight women out of 550 had a normal DIPSI but an abnormal WHO 2013 test. Thirty‐seven (63.8%) women out of 58 had adverse fetomaternal outcomes. We found statistically significant association between adverse fetomaternal outcome and GDM by WHO 2013 test (with normal DIPSI test).ConclusionWHO 2013 has superior diagnostic value compared with DIPSI criteria for diagnosis of GDM.
Time‐resolved SWIR imaging for the assessment of the activity of occlusal caries lesions
Authors: Ng Morgan , Wycoff Spencer , Zhu Yihua , Ho Yi‐Ching , Takasuka Hannah , Fried Daniel 
Published: June 2023

AbstractThe aim of this study was to develop a clinical SWIR reflectance handpiece to assess the activity of lesions on the occlusal surfaces. The time‐resolved reflectivity of 10 active and 10 arrested occlusal caries lesions on extracted teeth was monitored at 1470 nm using a benchtop system and a modified clinical prototype during forced air drying. The presence of a highly mineralized surface layer measured with microcomputed tomography (microCT) was used to indicate lesion activity. Multiple kinetic parameters were extracted from the acquired SWIR time versus intensity dehydration curves and used to assess lesion activity. Three parameters: delay, %Ifin, and rate calculated from the SWIR dehydration curves were significantly different (p < 0.05) between active and arrested lesions. The modified clinical probe was able to completely dehydrate all the active lesion areas in the occlusal pits and fissures in less than 30 s.
Geographic distance and tax fundamentals: An empirical analysis of location choice of Japanese firms’ outbound mergers and acquisitions
Authors: Jiang Yanwen 
Published: June 2023

AbstractThe deterrent effect of geographic distance on international expansion has been extensively examined in extant literature; however, little is known about whether tax‐related firm‐level characteristics could moderate the deterrent effect although both merger and acquisition (M&A) location decisions and tax‐related decisions involve considerable managerial judgments. Results using data on Japanese firms’ outbound M&A from 2010 to 2020 after Japan shifted from a worldwide tax system to a territorial tax system show that the deterrent effect of geographic distance is moderated by high tax avoidance, use of a tax consolidation regime, and a high level of deferred tax asset (DTA) balance. Additionally, we find that the 2017 Tax Reform on Japanese controlled foreign company (CFC) rules reduced the moderating effect of use of a consolidation regime, whereas it enhanced the moderating effect of a high level of DTA balance. These results call for a radical change in further research on various distances to incorporate insight from a tax perspective.
Pharmacokinetics of Antiretroviral Agents in Pregnant Individuals Living With HIV: Current Status and Considerations for Study Design and Interpretation
Authors: Choi Su‐Young , Yang Xiaoxia , Belew Yodit , Struble Kimberly , Reynolds Kellie 
Published: June 2023

AbstractDetermining the appropriate dosing regimens of antiretroviral (ARV) drugs for pregnant individuals living with HIV‐1 infection is critical to maximize maternal health and prevent perinatal HIV transmission. Throughout pregnancy, pharmacokinetics (PK) of ARVs can be significantly altered due to physiological, anatomic, and metabolic changes. As such, conducting PK studies of ARVs during pregnancy is crucial to optimize dosing regimens. In this article, we summarize available data, key issues, challenges, and considerations in interpreting results of ARV PK studies in pregnant individuals. Discussion topics include the choice of the reference population (postpartum vs historical control), pregnancy trimester‐dependent changes in ARV PK, effects of pregnancy on once‐ versus twice‐daily dosing, factors to consider for ARVs that are administered with a PK booster such as ritonavir and cobicistat, and considerations when evaluating the effects of pregnancy on unbound ARV concentrations. Common approaches for the translation of the results into clinical recommendations and rationales and considerations when making clinical recommendations are summarized. Currently, limited PK data in pregnancy are available with long‐acting ARVs. Collection of PK data to characterize the PK profile of long‐acting ARVs is an important goal shared by many stakeholders.
Pharmacokinetics of Antidepressants in Pregnancy
Authors: Yue Min , Kus Lauren , Katta Shilpa , Su Isaac , Li Lang , Haas David M. , Quinney Sara K. 
Published: June 2023

AbstractDepression is common in pregnant women. However, the rate of antidepressant treatment in pregnancy is significantly lower than in nonpregnant women. Although some antidepressants may cause potential risks to the fetus, not treating or withdrawing the treatment is associated with relapsing and adverse pregnancy outcomes such as preterm birth. Pregnancy‐associated physiologic changes can alter pharmacokinetics (PK) and may impact dosing requirements during pregnancy. However, pregnant women are largely excluded from PK studies. Dose extrapolation from the nonpregnant population could lead to ineffective doses or increased risk of adverse events. To better understand PK changes during pregnancy and guide dosing decisions, we conducted a literature review to catalog PK studies of antidepressants in pregnancy, with a focus on maternal PK differences from the nonpregnant population and fetal exposure. We identified 40 studies on 15 drugs, with most data from patients taking selective serotonin reuptake inhibitors and venlafaxine. Most of the studies have relatively poor quality, with small sample sizes, reporting concentrations at delivery only, a large amount of missing data, and not including times and adequate dose information. Only four studies collected multiple samples following a dose and reported PK parameters. In general, there are limited data available regarding PK of antidepressants in pregnancy and deficiencies in data reporting. Future studies should provide accurate information on drug dosing and timing of dose, PK sample collection, and individual‐level PK data.
A population‐level application of a method for estimating the timing of HIV acquisition among migrants to Australia
Authors: King Jonathan M. , Petoumenos Kathy , Dobbins Timothy , Guy Rebecca J. , Gray Richard T. , Nigro Steven J. , Si Damin , Minas Byron , McGregor Skye 
Published: June 2023

AbstractIntroductionAustralia has set the goal for the virtual elimination of HIV transmission by the end of 2022, yet accurate information is lacking on the level of HIV transmission occurring among residents. We developed a method for estimating the timing of HIV acquisition among migrants, relative to their arrival in Australia. We then applied this method to surveillance data from the Australian National HIV Registry with the aim of ascertaining the level of HIV transmission among migrants to Australia occurring before and after migration, and to inform appropriate local public health interventions.MethodsWe developed an algorithm incorporating CD4+ T‐cell decline back‐projection and enhanced variables (clinical presentation, past HIV testing history and clinician estimate of the place of HIV acquisition) and compared it to a standard algorithm which uses CD4+ T‐cell back‐projection only. We applied both algorithms to all new HIV diagnoses among migrants to estimate whether HIV infection occurred before or after arrival in Australia.ResultsBetween 1 January 2016 and 31 December 2020, 1909 migrants were newly diagnosed with HIV in Australia, 85% were men, and the median age was 33 years. Using the enhanced algorithm, 932 (49%) were estimated to have acquired HIV after arrival in Australia, 629 (33%) before arrival (from overseas), 250 (13%) close to arrival and 98 (5%) were unable to be classified. Using the standard algorithm, 622 (33%) were estimated to have acquired HIV in Australia, 472 (25%) before arrival, 321 (17%) close to arrival and 494 (26%) were unable to be classified.ConclusionsUsing our algorithm, close to half of migrants diagnosed with HIV were estimated to have acquired HIV after arrival in Australia, highlighting the need for tailored culturally appropriate testing and prevention programmes to limit HIV transmission and achieve elimination targets. Our method reduced the proportion of HIV cases unable to be classified and can be adopted in other countries with similar HIV surveillance protocols, to inform epidemiology and elimination efforts.
Aging and injury affect nuclear shape heterogeneity in tendon
Authors: Tinguely Yann , Shi Vivian , Klatte‐Schulz Franka , Duda Georg N. , Freedman Benjamin R. , Mooney David J. 
Published: June 2023

AbstractTissue level properties are commonly studied using histological stains assessed with qualitative scoring methods. As qualitative evaluation is typically insensitive, quantitative analysis provides additional information about pathological mechanisms, but cannot capture structural heterogeneity across cell subpopulations. However, molecular analyses of cell and nuclear behavior have identified that cell and more recently also nuclear shape are highly associated with cell function and malfunction. This study combined a Visually Aided Morpho‐Phenotyping Image Recognition analysis that automatically segments cells based on their shape with an added capacity to further discriminate between cells in certain protein‐rich extracellular matrix regions. We used tendon as a model system given the enormous changes in organization and cell and nuclear shape they undergo during aging and injury. Our results uncover that multiple shape modes of nuclei exist during maturity and aging in rat tendon and that distinct subgroups of cell nuclei shapes exist in proteoglycan‐rich regions during aging. With injury, several immunomarkers (αSMA, CD31, CD146) were associated with more rounded shape modes. In human tendons, the cell nuclei at sites of injury were found to be more rounded relative to uninjured tissues. To conclude, the tendon tissue changes occurring during aging and injury could be associated with a variation in cell nuclear morphology and the appearance of various region‐specific subpopulations. Thus, the methodologies developed allow for a deeper understanding of cell heterogeneity during tendon aging and injury and may be extended to study further clinical applications.