bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new Lean tool for efficiency evaluation in SMED projects
Authors: Braglia Marcello , Di Paco Francesco , Marrazzini Leonardo 
Published: May 2023

AbstractThe ability of companies to rapidly conduct a changeover from one product to another as part of a production process is a fundamental step towards a more flexible production system that can deal with an increasingly dynamic and competitive market. Single-Minute Exchange of Die (SMED) is the best-known lean tool that aims to reduce time consumption in the changeover process. This paper presents a new lean tool called Set-up Saving Deployment (SSD), which improves set-up efficiency by classifying, analyzing, and removing set-up losses within a changeover process, and which supports decision-making for SMED implementation. SSD uses three matrices, constructed sequentially from the first (L-Matrix) to the last (ECE-Matrix), in order to assess the possible time savings that can be achieved by eliminating losses and, in addition, to forecast possible improvements resulting from implementing a SMED project. SSD also provides a new basket of tailored set-up efficiency indicators that allow the analysis team to correctly assess set-up efficiency and compare the “as is” condition with the subsequent “to be” condition from an operational perspective. The effectiveness of SSD in addressing set-up losses and predicting time savings is illustrated using an industrial case study of a resin-doming machine. Thanks to its structured step-by-step procedure, SSD significantly improves the efficiency of the changeover process.
The paint pot problem and common multiples in monoids
Authors: Zantema Hans , van Oostrom Vincent 
Published: May 2023

Abstract
Illustrated by a problem on paint pots that is easy to understand but hard to solve, we investigate whether particular monoids have the property of common right multiples. As one result we characterize generalized braid monoids represented by undirected graphs, being a subclass of Artin–Tits monoids. Stated in other words, we investigate to which graphs the old Garside result stating that braid monoids have the property of common right multiples, generalizes. This characterization also follows from old results on Coxeter groups and the connection between finiteness of Coxeter groups and common right multiples in Artin–Tits monoids. However, our independent presentation is self-contained up to some basic knowledge of rewriting, and also applies to monoids beyond the Artin–Tits format. The main new contribution is a technique to prove that the property of common right multiples does not hold, by finding a particular model, in our examples all being finite.
Intramuscular coherence enables robust assessment of modulated supra-spinal input in human gait: an inter-dependence study of visual task and walking speed
Authors: Zipser-Mohammadzada Freschta , Scheffers Marjelle Fredie , Conway Bernard A. , Halliday David M. , Zipser Carl Moritz , Curt Armin , Schubert Martin 
Published: May 2023

AbstractIntramuscular high-frequency coherence is increased during visually guided treadmill walking as a consequence of increased supra-spinal input. The influence of walking speed on intramuscular coherence and its inter-trial reproducibility need to be established before adoption as a functional gait assessment tool in clinical settings. Here, fifteen healthy controls performed a normal and a target walking task on a treadmill at various speeds (0.3 m/s, 0.5 m/s, 0.9 m/s, and preferred) during two sessions. Intramuscular coherence was calculated between two surface EMG recordings sites of the Tibialis anterior muscle during the swing phase of walking. The results were averaged across low-frequency (5–14 Hz) and high-frequency (15–55 Hz) bands. The effect of speed, task, and time on mean coherence was assessed using three-way repeated measures ANOVA. Reliability and agreement were calculated with the intra-class correlation coefficient and Bland–Altman method, respectively. Intramuscular coherence during target walking was significantly higher than during normal walking across all walking speeds in the high-frequency band as obtained by the three-way repeated measures ANOVA. Interaction effects between task and speed were found for the low- and high-frequency bands, suggesting that task-dependent differences increase at higher walking speeds. Reliability of intramuscular coherence was moderate to excellent for most normal and target walking tasks in all frequency bands. This study confirms previous reports of increased intramuscular coherence during target walking, while providing first evidence for reproducibility and robustness of this measure as a requirement to investigate supra-spinal input.Trial registration Registry number/ClinicalTrials.gov Identifier: NCT03343132, date of registration 2017/11/17.
TechnoSapiens: merging humans with technology in augmented reality
Authors: Rudolph Carsten , Brunnett Guido , Bretschneider Maximilian , Meyer Bertolt , Asbrock Frank 
Published: May 2023

AbstractWe present a marker-less AR/DR system that can replace the arm of the user with a virtual bionic prosthesis in real time including finger tracking. For this, we use a mixed reality HMD that provides the user with a stereo image based on video-see-through (VST). We apply chroma-keying to remove the user’s arm from each captured image and input reconstructed background information into the removed pixels. Before rendering the prosthesis model into the image, we re-target motion capture data of the user’s hand to the kinematic skeleton of the prosthesis to match the current hand pose. This system opens new research possibilities on self- and other-perception of bionic bodies. In a first evaluation study of the system, we propose that users perceive the virtual prosthesis model as a part of their body (i.e., that they experience a sense of ownership). We tested this assumption in a laboratory study with 27 individuals who used the system to perform a series of simple tasks in AR with their prosthesis. We measured body ownership and other measures with self-reports. In support of the hypothesis, users experienced a sense of body ownership. Also, a feeling of self-presence is induced during the task, and participants rated the overall experience as positive.
Temperature-specific spectral shift of luminescing thermally altered human remains
Authors: Schariatmadary Parnia , Aalders Maurice C. G. , Oostra Roelof-Jan , Krap Tristan 
Published: May 2023

AbstractHuman bone has shown to have luminescent properties that remain throughout the phases of cremation, with the exception of fully carbonized bone, when excited with a narrow band light source. During this research, an alternate light source (420–470nm, peak at 445nm) was used to visualize and investigate latent details relevant for forensic investigations of human remains recovered at fire scenes. As fire is a destructive force, it induces a vast variety of physical and chemical alterations to all components of the bone, making the subsequent analysis and interpretation of burned human remains challenging. A spectral shift in emission bandwidth, from green to red, was previously observed when the exposure temperature increased from 700 to 800 °C. This spectral shift was reproduced on a total of 10 human forearms, divided into 20 segments, by burning at 700 °C and 900 °C in an ashing furnace. The shift of emission bandwidth caused only by an increase in temperature was furthermore investigated by colorimetric analysis, proving the spectral shift to be significant. By easily quantifying the spectral shift, substantiation is provided for the use of this technique in practice to improve the interpretation of heat induced changes of bone.
Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers
Authors: Bede Peter , Lulé Dorothée , Müller Hans-Peter , Tan Ee Ling , Dorst Johannes , Ludolph Albert C. , Kassubek Jan 
Published: May 2023

Abstract
Background
The characterisation of presymptomatic disease-burden patterns in asymptomatic mutation carriers has a dual academic and clinical relevance. The understanding of disease propagation mechanisms is of considerable conceptual interests, and defining the optimal time of pharmacological intervention is essential for improved clinical trial outcomes.

Methods
In a prospective, multimodal neuroimaging study, 22 asymptomatic C9orf72 GGGGCC hexanucleotide repeat carriers, 13 asymptomatic subjects with SOD1, and 54 “gene-negative” ALS kindreds were enrolled. Cortical and subcortical grey matter alterations were systematically appraised using volumetric, morphometric, vertex, and cortical thickness analyses. Using a Bayesian approach, the thalamus and amygdala were further parcellated into specific nuclei and the hippocampus was segmented into anatomically defined subfields.

Results
Asymptomatic GGGGCC hexanucleotide repeat carriers in C9orf72 exhibited early subcortical changes with the preferential involvement of the pulvinar and mediodorsal regions of the thalamus, as well as the lateral aspect of the hippocampus. Volumetric approaches, morphometric methods, and vertex analyses were anatomically consistent in capturing focal subcortical changes in asymptomatic C9orf72 hexanucleotide repeat expansion carriers. SOD1 mutation carriers did not exhibit significant subcortical grey matter alterations. In our study, none of the two asymptomatic cohorts exhibited cortical grey matter alterations on either cortical thickness or morphometric analyses.

Discussion
The presymptomatic radiological signature of C9orf72 is associated with selective thalamic and focal hippocampal degeneration which may be readily detectable before cortical grey matter changes ensue. Our findings confirm selective subcortical grey matter involvement early in the course of C9orf72-associated neurodegeneration.
Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute calculous cholecystitis in patients over 90 years of age
Authors: Ramírez-Giraldo Camilo , Isaza-Restrepo Andrés , Rico-Rivera Enid Ximena , Vallejo-Soto Juan Carlos , Van-Londoño Isabella 
Published: May 2023

Abstract
Background
Laparoscopic cholecystectomy (LC) is the standard of care for acute calculous cholecystitis; however, in patients at high risk for surgery, particularly in the elderly, insertion of a percutaneous catheter drainage (PCD) at gallbladder is recommended. Current evidence suggests that PCD may have less favorable outcomes than LC, but also that LC-associated complications increase in direct relation to patient age. There is no recommendation supported by robust evidence to decide between one or the other procedure in super elderly patients.

Methods
A retrospective observational cohort study was designed to analyze the surgical outcomes of super elderly patients with cholecystitis who underwent LC versus PCD for treatment. The surgical outcomes of a subgroup of high-risk patients were also analyzed.

Results
A total of 96 patients who met the inclusion criteria between 2014 and 2021 were included. The median age of patients were 92 years (IQR: 4.00) with a female predominance (58.33%). The overall morbidity rate in the series was 36.45% and mortality rate was 7.29%. There was no statistically significant difference when compared to the associated morbidity and mortality among patients who underwent LC versus those who underwent PCD, neither in the analysis of the complete series or in the subgroup of high-risk patients.

Conclusions
The morbidity and mortality associated with the two most frequently recommended therapeutic options for operating super elderly patients with acute cholecystitis are high. We found no evidence of superiority in outcomes for either of the two procedures in this age group.
Adjuvant and neoadjuvant use of immune checkpoint inhibitors in NSCLC
Authors: Walia Anushka , Prasad Vinay 
Published: May 2023

AbstractThe neoadjuvant and adjuvant use of immune checkpoint inhibitors (ICIs) in early stage non-small cell lung cancer (NSCLC) is increasing, with pembrolizumab approved as adjuvant therapy following surgical resection and chemotherapy by the U.S. Food and Drug Administration in early 2023. However, clinical trials of these agents have several key limitations including the use of surrogate endpoints that have not been validated and a lack of demonstrated survival benefit. Further data supporting the benefits of ICIs in this setting are necessary to justify their use at the cost of greater financial burdens, time, and adverse effects.
Filamin-A-interacting protein 1 (FILIP1) is a dual compartment protein linking myofibrils and microtubules during myogenic differentiation and upon mechanical stress
Authors: Grande Valentina , Schuld Julia , van der Ven Peter F. M. , Gruss Oliver J. , Fürst Dieter O. 
Published: May 2023

AbstractVariations in the gene encoding filamin-A-interacting protein 1 (FILIP1) were identified to be associated with a combination of neurological and muscular symptoms. While FILIP1 was shown to regulate motility of brain ventricular zone cells, a process important for corticogenesis, the function of the protein in muscle cells has been less well characterized. The expression of FILIP1 in regenerating muscle fibres predicted a role in early muscle differentiation. Here we analysed expression and localization of FILIP1 and its binding partners filamin-C (FLNc) and microtubule plus-end-binding protein EB3 in differentiating cultured myotubes and adult skeletal muscle. Prior to the development of cross-striated myofibrils, FILIP1 is associated with microtubules and colocalizes with EB3. During further myofibril maturation its localization changes, and FILIP1 localizes to myofibrillar Z-discs together with the actin-binding protein FLNc. Forced contractions of myotubes by electrical pulse stimulation (EPS) induce focal disruptions in myofibrils and translocation of both proteins from Z-discs to these lesions, suggesting a role in induction and/or repair of these structures. The immediate proximity of tyrosylated, dynamic microtubules and EB3 to lesions implies that also these play a role in these processes. This implication is supported by the fact that in nocodazole-treated myotubes that lack functional microtubules, the number of lesions induced by EPS is significantly reduced. In summary, we here show that FILIP1 is a cytolinker protein that is associated with both microtubules and actin filaments, and might play a role in the assembly of myofibrils and their stabilization upon mechanical stress to protect them from damage.
Modelling bivariate failure time data via bivariate extended Chen distribution
Authors: Kilany N. M. , El-Qareb F. G. 
Published: May 2023

AbstractFatal Shock, competing risks and stress models are utilized in reliability and survival analysis to characterize various application types. In this context, this paper aimed to introduce a new class of bivariate distribution based on the Marshall–Olkin type. The proposed distribution termed as the Bivariate Extended Chen (BEC) distribution so that the marginals have Extended Chen distribution. Some properties of this distribution are derived and explained. The BEC distribution parameters are estimated using the maximum likelihood method. Finally, two applications to real life applications highlight the significance and adaptability of the Bivariate Extended Chen (BEC) distribution. The BEC distribution offers a superior fit than different competing bivariate distributions, illustrating its flexibility and applicability in modelling.
Acute kidney injury: a strong risk factor for hypoglycaemia in hospitalized patients with type 2 diabetes
Authors: Carreira Ana , Castro Pedro , Mira Filipe , Melo Miguel , Ribeiro Pedro , Santos Lèlita 
Published: May 2023

Abstract
Aims
Acute kidney injury (AKI) is highly prevalent during hospitalization of patients with type 2 diabetes (T2D). We aimed to assess the impact of AKI and its severity and duration on the risk of hypoglycaemia in hospitalized patients with T2D.

Methods
Retrospective cohort analysis of patients with T2D, admitted at a University Hospital in 2018–2019. AKI was defined as an increase in serum creatinine by ≥ 0.3 mg/dl (48 h) or ≥ 1.5 times baseline (7 days), and hypoglycaemia as blood glucose concentration < 70 mg/dl. Patients with chronic kidney disease stage ≥ 4 were excluded. We registered 239 hospitalizations with AKI and randomly selected 239 without AKI (control). Multiple logistic regression was used to adjust for confounding factors and ROC curve analysis to determine a cutoff for AKI duration.

Results
The risk of hypoglycaemia was higher in the AKI group (crude OR 3.6, 95%CI 1.8–9.6), even after adjusting for covariates (OR 4.2, 95%CI 1.8–9.6). Each day of AKI duration was associated with a 14% increase in the risk of hypoglycaemia (95%CI 1.1–1.2), and a cutoff of 5.5 days of AKI duration was obtained for increased risk of hypoglycaemia and mortality. AKI severity was also associated with mortality, but showed no significant association with hypoglycaemia. Patients with hypoglycaemia had 4.4 times greater risk of mortality (95%CI 2.4–8.2).

Conclusions
AKI increased the risk of hypoglycaemia during hospitalization of patients with T2D, and its duration was the main risk factor. These results highlight the need for specific protocols to avoid hypoglycaemia and its burden in patients with AKI.
Aptamer-functionalized stir bar sorptive extraction for selective isolation, identification, and determination of concanavalin A in food by MALDI-TOF-MS
Authors: Vergara-Barberán María , Catalá-Icardo Mónica , Simó-Alfonso Ernesto F. , Benavente Fernando , Herrero-Martínez José Manuel 
Published: May 2023

AbstractAn aptamer-functionalized stir bar sorptive extraction (SBSE) coating is described for the first time devoted to selective isolation and preconcentration of an allergenic food protein, concavanalin A (Con A), followed by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS) determination. For this purpose, the polytetrafluoroethylene surface of commercial magnetic stir bars was properly modified and vinylized to immobilize a thiol-modified aptamer against Con A via straightforward “thiol-ene” click chemistry. The aptamer-functionalized stir bar was employed as SBSE sorbent to isolate Con A, and several parameters that can affect the extraction efficiency were investigated. Under the optimized conditions, Con A was extracted and desorbed during 30 and 45 min, respectively, at 25 °C and 600 rpm. The SBSE MALDI-TOF-MS method provided limits of detection of 0.5 μg mL−1 for Con A. Furthermore, the SBSE coating was highly selective to Con A compared to other lectins. The developed method was successfully applied to the determination of low levels of Con A in several food matrices (i.e., white beans as well as chickpea, lentils, and wheat flours). Recoveries ranged from 81 to 97% with relative standard deviations below 7%. The aptamer-based stir bars presented suitable physical and chemical long-term stability (1 month) and a reusability of 10 and 5 extraction cycles with standards and food extracts, respectively. The developed aptamer-affinity extraction devices open up the possibility of developing novel highly selective SBSE coatings for the extraction of proteins and peptides from complex samples.
Graphical abstract
Microsurgical clipping as a retreatment strategy for previously ruptured aneurysms treated with the Woven EndoBridge (WEB) device: a mono-institutional case series
Authors: Kranawetter B. , Hernández S. , Mielke D. , Ernst M.S. , Malinova V. , Rohde V. 
Published: May 2023

Abstract
Background
Since its approval by the US Food and Drug Administration (FDA) in 2018, the flow disruptor Woven EndoBridge (WEB) device has become increasingly popular for the endovascular treatment of unruptured and ruptured cerebral aneurysms. However, the occlusion rates seem rather low and the retreatment rates rather high compared to other treatment methods. For initially ruptured aneurysms, a retreatment rate of 13 % has been reported. A variety of retreatment strategies has been proposed; however, there is a paucity of data concerning microsurgical clipping of WEB-pretreated aneurysms, especially previously ruptured ones. Thus, we present a single-center series of five ruptured aneurysms treated with the WEB device and retreated with microsurgical clipping.

Methods
A retrospective study including all patients presenting with a ruptured aneurysm undergoing WEB treatment at our institution between 2019 and 2021 was performed. Subsequently, all patients with an aneurysm remnant or recurrence of the target aneurysm retreated with microsurgical clipping were identified.

Results
Overall, five patients with a ruptured aneurysm treated with WEB and retreated with microsurgical clipping were included. Besides one basilar apex aneurysm, all aneurysms were located at the anterior communicating artery (AComA) complex. All aneurysms were wide-necked with a mean dome-to-neck ratio of 1.5. Clipping was feasible and safe in all aneurysms, and complete occlusion was achieved in 4 of 5 aneurysms.

Conclusions
Microsurgical clipping for initially ruptured WEB-treated aneurysms is a feasible, safe, and effective treatment method in well-selected patients.
Intruding into a conversation: how behavioral manipulation could support management of Xylella fastidiosa and its insect vectors
Authors: Avosani Sabina , Nieri Rachele , Mazzoni Valerio , Anfora Gianfranco , Hamouche Zeinab , Zippari Caterina , Vitale Maria Luisa , Verrastro Vincenzo , Tarasco Eustachio , D’Isita Ilaria , Germinara Salvatore , Döring Thomas F. , Belusic Gregor , Fereres Alberto , Thompson Vinton , Cornara Daniele 
Published: May 2023

AbstractBehavioral manipulation (BM) is a multimodal control approach based on the interference with the stimuli mediating insect perception and interaction with the surroundings. BM could represent a win–win strategy for the management of vector-borne plant pathogens as the bacterium Xylella fastidiosa, since it could reduce the number of vectors alighting on host plants and, consequently, the chances for transmission to occur. In this review, we summarized current knowledge and highlighted gaps in information on (i) how insect vectors of X. fastidiosa in general, and more specifically the meadow spittlebug Philaenus spumarius, locate and accept the host plant; and (ii) how behavioral manipulation techniques could be applied to disrupt the vector–host plant interaction. Finally, we discussed how diverse BM strategies could be combined with other integrated pest management tools to protect olive groves from inoculation with the fastidious bacterium.
Pest science in Pasteur’s Quadrant
Authors: Mangel Marc 
Published: May 2023

AbstractMore than 25 years ago, Donald Stokes argued that we must move beyond the false dichotomy of basic or applied research and suggested that when considering a program of scientific research it is important to ask whether (i) the work is motivated by use and (ii) if there is a search for fundamental understanding. Giving yes/no answers to these questions allows us to characterize research more fully, replacing the “or” of “basic or applied” by a richer understanding of the process of science. Stokes proposed that research that was motivated by a consideration of use and sought fundamental understanding be called research in Pasteur’s Quadrant. One advantage of such work is that the search for fundamental understanding means that the problem-solving tools are more likely to be transferrable. After reviewing Stokes’s formulation of research, I illustrate it with examples from the control of tephritid flies and the use of insect parasitoids for biological control. Thinking about one’s work within Stokes’s framework has many advantages for individual scientists, including guidance for journal selection, how to organize and conclude papers and seminars, and the “elevator speech.” Furthermore, since research in Pasteur’s Quadrant has the characteristic of simultaneously increasing our understanding of how the world works and improving applications, it will more likely benefit the community of pest scientists.