bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid‐correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia
Authors: Arihisa Wataru , Kondo Takeshi , Yamaguchi Katsushi , Matsumoto Junya , Nakanishi Hiroki , Kunii Yasuto , Akatsu Hiroyasu , Hino Mizuki , Hashizume Yoshio , Sato Shumpei , Sato Shinji , Niwa Shin‐Ichi , Yabe Hirooki , Sasaki Takehiko , Shigenobu Shuji , Setou Mitsutoshi 
Published: July 2023

AbstractAimsSchizophrenia is a chronic relapsing psychiatric disorder that is characterized by many symptoms and has a high heritability. There were studies showing that the phospholipid abnormalities in subjects with schizophrenia (Front Biosci, S3, 2011, 153; Schizophr Bull, 48, 2022, 1125; Sci Rep, 7, 2017, 6; Anal Bioanal Chem, 400, 2011, 1933). Disturbances in prefrontal cortex phospholipid and fatty acid composition have been reported in subjects with schizophrenia (Sci Rep, 7, 2017, 6; Anal Bioanal Chem, 400, 2011, 1933; Schizophr Res, 215, 2020, 493; J Psychiatr Res, 47, 2013, 636; Int J Mol Sci, 22, 2021). For exploring the signaling pathways contributing to the lipid changes in previous study (Sci Rep, 7, 2017, 6), we performed two types of transcriptome analyses in subjects with schizophrenia: an unbiased transcriptome analysis solely based on RNA‐seq data and a correlation analysis between levels of gene expression and lipids.MethodsRNA‐Seq analysis was performed in the postmortem prefrontal cortex from 10 subjects with schizophrenia and 5 controls. Correlation analysis between the transcriptome and lipidome from 9 subjects, which are the same samples in the previous lipidomics study (Sci Rep, 7, 2017, 6).ResultsExtraction of differentially expressed genes (DEGs) and further sequence and functional group analysis revealed changes in gene expression levels in phosphoinositide 3‐kinase (PI3K)‐Akt signaling and the complement system. In addition, a correlation analysis clarified alterations in ether lipid metabolism pathway, which is not found as DEGs in transcriptome analysis alone.ConclusionsThis study provided results of the integrated analysis of the schizophrenia‐associated transcriptome and lipidome within the PFC and revealed that lipid‐correlated alterations in the transcriptome are enriched in specific pathways including ether lipid metabolism pathway.
Reinforcement effect of glass fiber modified by tannic acid and polyethyleneimine on polyamide 6 composites with no volatile organic compounds emission
Authors: Luo Kaiqiang , Guo Jinjing , Xu Jun , Guo Baohua 
Published: July 2023

AbstractAs an important surface modifier, conventional silane coupling agents generally emit volatile organic compounds (VOCs) like methanol or ethanol during the modification of glass fiber. To avoid VOCs emission, a phenol/amine co‐deposition of tannic acid (TA) with polyethyleneimine (PEI) was used to modify glass fiber (TP‐GF) based on mussel‐inspired surface chemistry. The reinforcement effect of TP‐GF on polyamide 6 (PA6) matrix was investigated, and the corresponding results were compared with those of γ‐aminopropyltriethoxysilane (KH550) modified glass fiber (KH550‐GF)/PA6 composites. The results showed that the interfacial adhesion between TP‐GF and PA6 matrix was superior to that between KH550‐GF and PA6 matrix, and thus TP‐GF/PA6 composites manifested more excellent mechanical properties than KH550‐GF/PA6 composites. Among these composites, TP‐GF (1.05 wt% of coating amount)/PA6 composites exhibited the optimal mechanical properties (tensile strength: 151.3 MPa, notched impact strength: 13.8 kJ m−2) compared with KH550‐GF (1.33 wt% of coating amount)/PA6 composites (tensile strength: 144.8 MPa, notched impact strength: 9.5 kJ m−2). In particular, the notched impact strength was significantly increased by 45%. Notably, there was no VOCs generation during the preparation of TP‐GF, indicating that TP‐GF could be used as an environmentally friendly glass fiber for the fabrication of high‐performance PA6 composites.
How to approach a study in ethnopharmacology? Providing an example of the different research stages for newcomers to the field today
Authors: Schultz Fabien , Garbe Leif‐Alexander 
Published: July 2023

AbstractEthnopharmacology seeks to investigate humankind's use of natural materials, such as plants, fungi, microorganisms, animals, and minerals, for medicinal purposes. In this highly interdisciplinary field, which can be described as a bridge between the natural/medical and socio‐cultural sciences, pharmacological, anthropological, and socio‐cultural research methods are often applied, along with methods from other branches of science. When entering the field of ethnopharmacology as a newcomer, student, or early career researcher today, the tremendous amount of scientific publications, and even classical books from this field and related scientific disciplines, can be overwhelming. Ethnopharmacology has evolved over the past decades, and new key topics, such as the decolonization of the field, issues on intellectual property and benefit‐sharing, species conservation, the preservation of traditional knowledge, the protection of indigenous communities, science outreach, and climate change, have become important and urgent aspects of the field that must not be disregarded by today's ethnopharmacologists. One of the questions of newcomers will be, “Where to begin?” This review article offers a brief (and certainly not comprehensive) introduction to the science of ethnopharmacology, highlighting some of its past most notable achievements and future prospects. In addition, this article provides an example for newcomers to the field of how to address different stages that may be involved in conducting ethnopharmacological field and lab studies, including early‐stage drug discovery and community work. The example presented summarizes a series of studies conducted in the remote Greater Mpigi region of Uganda, located in East Africa. Stages of ethnopharmacological research described include ethnobotanical surveying and fieldwork, the pharmacological assessment of activity with diverse targets in the laboratory, and the transfer of results back to indigenous communities, that is, non‐financial benefit sharing as a potential best practice example. As a result of this research example, a total of six original research articles have been published on the medicinal application and ethnopharmacology of 16 plant species from the Ugandan study site, offering a large quantity of results. These six publications reflect the multifaceted nature of the interdisciplinary science of ethnopharmacology, which may serve as a reference point and inspiration for newcomers to design and conduct their own independent ethnopharmacological research endeavors at other study sites. Major bottlenecks and solutions are provided, and the current social media channels with educational ethnopharmacological content are briefly introduced.
Towards autonomous selective harvesting: A review of robot perception, robot design, motion planning and control
Authors: Rajendran Vishnu , Debnath Bappaditya , Mghames Sariah , Mandil Willow , Parsa Soran , Parsons Simon , Ghalamzan‐E. Amir 
Published: July 2023

AbstractThis paper provides an overview of the current state‐of‐the‐art in selective harvesting robots (SHRs) and their potential for addressing the challenges of global food production. SHRs have the potential to increase productivity, reduce labor costs, and minimize wastage by selectively harvesting only ripe fruits and vegetables. The paper discusses the main components of SHRs, including perception, grasping, cutting, motion planning, and control. It also highlights the challenges in developing SHR technologies, particularly in the areas of robot design, motion planning, and control. The paper also discusses the potential benefits of integrating artificial intelligence and soft robots and data‐driven methods to enhance the performance and robustness of SHR systems. Finally, the paper identifies several open research questions in the field and highlights the need for further research and development efforts to advance SHR technologies to meet the challenges of global food production. Overall, this paper provides a starting point for researchers and practitioners interested in developing SHRs and highlights the need for more research in this field.
Confronting Otherness: The Built Environments in Adrian Tchaikovsky’s Shadows of the Apt
Authors: Chudoba Minna 
Published: July 2023

AbstractConfronting the unfamiliar is a common theme in the fantasy fiction genre. British author Adrian Tchaikovsky underlines this theme in his ten-book series Shadows of the Apt (2008–2014) with a dichotomy of apt–inapt. This is enhanced by the insect-derived traits of the characters, which are reflected in the cities of this imagined fantasy world. Various urban architectures provide backgrounds for the protagonists as they face a foreign reality. The reader interpretation presented here focuses on the urban spaces and the architecture. The reading is structured by a division into strategies and tactics, as defined by Michel de Certeau. This provides a basis for understanding the interaction between the spaces and the spatial practices of the protagonists, as they move about in unfamiliar surroundings, confronting otherness. The architectural reading of the story opens the scalar structure used by the author and underlines the importance of the collective in the individual growth stories.
Domestic and International Drivers and Challenges for the Energy Transformation in the MENA Region
Authors: Hafner Manfred , Raimondi Pier Paolo , Bonometti Benedetta 
Published: July 2023

AbstractThe chapter examines the domestic and international drivers and obstacles for the transformation in the MENA region. It outlines the major domestic sociopolitical and economic features that could both incentivize and discourage the energy transformation in the region. These are the pervasive role of oil rents, high energy subsidies, high dependence on cheap imported labour force and low role of private sector. The transformation is also pushed by rising international climate pressure but also the need to adapt and mitigate the existing negative consequences of climate change in the region, which are expected to exacerbate the regional fragile environment (e.g. rising temperatures and sea levels as well as water stress and scarcity).
National Energy Sectors: Historical Evolution and Current Situation
Authors: Hafner Manfred , Raimondi Pier Paolo , Bonometti Benedetta 
Published: July 2023

AbstractThis chapter presents the present energy, economic and political landscape of the MENA region, country by country. While fossil fuels have been at the center of this landscape in the MENA region, each MENA country has gone through a transformation of its energy system. Understanding this historical evolution is instrumental to better understand the starting point for future national energy transformations. While fossil fuels play a key role in all national energy sectors, countries vary regarding energy endowment, population size and economics. The chapter highlights the clear regional cleavage between hydrocarbon-exporting and hydrocarbon-importing countries and its consequences on national energy sector evolutions.
Players in the Crowdsourcing Industry
Authors: Hornuf Lars , Mangold Sonja , Yang Yayun 
Published: July 2023

AbstractDifferent classifications of crowdsourcing markets have been proposed. This chapter outlines the most relevant classifications and provides examples of crowdsourcing in its various forms. It offers a more complete definition of crowdsourcing, provides statistics of market developments, and discusses some of the larger market trends in China, Germany and the United States.
Summary and Conclusion
Authors: Hornuf Lars , Mangold Sonja , Yang Yayun 
Published: July 2023

AbstractThis chapter summarizes the results of this book and draws some legal policy conclusions. Our findings are mainly based on the analysis of legal framework conditions and the evaluation of the privacy statements of crowdsourcing platforms located in China, Germany and the U.S., presented in the preceding chapters. The results of this study provide inspiration for future research and legal action in the field of crowdsourcing and data privacy.
Engaging with the Public: Comparing the National Museum of Indonesia and the Kolong Tangga Museum from the New Museology Perspective
Authors: Rizqika Mawaddatul Khusna , Wahyudi Wanny Rahardjo 
Published: July 2023

AbstractNowadays, the views of new museology bring changes to museum management in various countries. This concept is deemed to optimize earlier theories and can accommodate the current needs of museums and the society. In Indonesia, new museology is a relatively new theory, although it originated in the 1970s within the international museum sphere. In the past, museums focused on their collections. At the moment, however, they have shifted their orientation to the society. Information dissemination becomes a priority and is related to surrounding social climates. Something similar has also occurred in the aspects of curatorial management. Curators have had to extend focus from only the material aspect of collections to also the meaning behind them.
Locating Sikuru, “Hero of Loloda”
Authors: Rahman Abd. , Christomy Tommy , Zuhdi Susanto , Putri L. G. Saraswati 
Published: July 2023

AbstractHaving wrapped up our 2017-2018 fieldwork in the Moluccas, we landed in Jakarta only to receive a short message from someone we did not know. In the message, the person asked, “Why are you researching Loloda? There is nothing in Loloda. You probably want to work on other regions. Loloda is long gone.” The text message made us rethink the position of Loloda, a region in the west coast of Halmahera Island, North Maluku, in society today. Loloda used to be one of the oldest kingdoms in the area during colonial times. Such a message contrasted with the enthusiasm of the people of Loloda that we witnessed during the field research, particularly after the appointment of Suaib bin Syamsudin Syah as kolano (king) of Loloda in 2016. Belittling Loloda is a postcolonial legacy in the local politics of the region today.
The Treaty of Tumbang Anoi, 1894: Impact on Borneo’s Social Structure
Authors: Haryanti Sitti Utami 
Published: July 2023

AbstractVisitors to the village of Tumbang Anoi, which lies upstream of the Kahayan River in the Gunung Mas Regency of Central Kalimantan, may not realize that it was the site of a groundbreaking historical event that significantly changed the life of the people of the Dayak tribe. Yet the event that took place over three long months in 1894 in this very village had done precisely that. What is now often referred to as the Tumbang Anoi Peaceful Meeting was attended by representatives of all the Dayak tribes in Kalimantan to discuss issues of Dayak customary law and possible solutions to disputes, producing a historically significant document called the Treaty of Tumbang Anoi. The meeting involved the colonial government of the Dutch East Indies and all Dayak tribes in Kalimantan. The figures involved at that time were the Dutch controlleur of Dayak Lands and other representatives from the Dutch East Indies colonial government. The Dayak tribes were represented by the central figure, the Damang Batu, or Damang Ribu, who facilitated the Peace Meeting. This event marks the beginning of the establishment of a new legal order that generally affected the Dayak tribal community. It also brought about a number of social changes among the Dayak people.
Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund’s adjuvant-induced paw inflammation model
Authors: Heydeck Dagmar , Kakularam Kumar R. , Labuz Dominika , Machelska Halina , Rohwer Nadine , Weylandt Karsten , Kuhn Hartmut 
Published: July 2023

Abstract
Background, objectives and design
Arachidonic acid 15-lipoxygenase (ALOX15) has been implicated in the pathogenesis of inflammatory diseases but since pro- and anti-inflammatory roles have been suggested, the precise function of this enzyme is still a matter of discussion. To contribute to this discussion, we created transgenic mice, which express human ALOX15 under the control of the activating protein 2 promoter (aP2-ALOX15 mice) and compared the sensitivity of these gain-of-function animals in two independent mouse inflammation models with Alox15-deficient mice (loss-of-function animals) and wildtype control animals.

Materials and methods
Transgenic aP2-ALOX15 mice were tested in comparison with Alox15 knockout mice (Alox15−/−) and corresponding wildtype control animals (C57BL/6J) in the complete Freund’s adjuvant induced hind-paw edema model and in the dextran sulfate sodium induced colitis (DSS-colitis) model. In the paw edema model, the degree of paw swelling and the sensitivity of the inflamed hind-paw for mechanic (von Frey test) and thermal (Hargreaves test) stimulation were quantified as clinical readout parameters. In the dextran sodium sulfate induced colitis model the loss of body weight, the colon lengths and the disease activity index were determined.

Results
In the hind-paw edema model, systemic inactivation of the endogenous Alox15 gene intensified the inflammatory symptoms, whereas overexpression of human ALOX15 reduced the degree of hind-paw inflammation. These data suggest anti-inflammatory roles for endogenous and transgenic ALOX15 in this particular inflammation model. As mechanistic reason for the protective effect downregulation of the pro-inflammatory ALOX5 pathways was suggested. However, in the dextran sodium sulfate colitis model, in which systemic inactivation of the Alox15 gene protected female mice from DSS-induced colitis, transgenic overexpression of human ALOX15 did hardly impact the intensity of the inflammatory symptoms.

Conclusion
The biological role of ALOX15 in the pathogenesis of inflammation is variable and depends on the kind of the animal inflammation model.
Prospective randomized clinical studies involving reirradiation: update of a systematic review
Authors: Nieder Carsten , Willmann Jonas , Andratschke Nicolaus H. 
Published: July 2023

Abstract
Background
Reirradiation is a potentially useful option for many patients with recurrent cancer, aiming at cure or symptom palliation, depending on disease/recurrence type and stage. The purpose of this follow-up study to a previous review from 2016 was to summarize all recently published randomized trials. Points of interest again included identifcation of methodological strengths and weaknesses, practice-changing results, and open questions.

Material and methods
Systematic review of trials published between 2015 and February 2023.

Results
We reviewed 7 additional trials, most of which addressed reirradiation of head and neck or brain tumours. The median number of patients was 60. Mirroring the previous review, trial design, primary endpoints and statistical hypotheses varied widely. The updated results only impact on decision making for reirradiation of nasopharynx cancer and glioma. Patients with one of these diseases, as well as other head and neck cancers, may benefit from reirradiation-induced local control, e.g. in terms of progression-free survival. For the first time, hyperfractionated radiotherapy emerged as preferred option for recurrent, inoperable nasopharynx cancer. Despite better therapeutic ratio with hyperfractionation, serious toxicity remains a concern after high cumulative total doses. Randomized trials are still lacking for prostate cancer and other sites.

Conclusion
Multicentric randomized trials on reirradiation are feasible and continue to refine the current standard of care for recurrent disease after previous radiotherapy. Ongoing prospective studies such as the European Society for Radiotherapy and Oncology and European Organisation for Research and Treatment of Cancer (ESTRO-EORTC) observational cohort ReCare (NCT: NCT03818503) will further shape the clinical practice of reirradiation.
Mandatory retirement savings in the presence of an informal labor market
Authors: Pardo Oliver 
Published: July 2023

AbstractThis paper shows how mandating workers to save more for retirement can lead them to work informally and save less. Consider a worker who is more productive in the formal sector but works informally to avoid mandatory retirement contributions. Lowering the contribution rate (the share of wages mandated to be saved) will paradoxically increase her retirement savings. The reason for this is that working informally acts as borrowing against mandatory savings. The implicit cost of such borrowing, and hence the opportunity cost of working informally, rises as the contribution rate drops. This creates a substitution effect favoring formal work, driving the worker towards the formal sector. As her formal income increases, the base for her mandatory contributions rises, expanding her retirement savings. Therefore, the optimal contribution rate is no greater than the highest contribution rate under which the worker prefers to work exclusively in the formal sector.
Changes in international immigration and internal native mobility after COVID-19 in the USA
Authors: Peri Giovanni , Zaiour Reem 
Published: July 2023

AbstractThe COVID-19 pandemic produced a significant decline in international immigration to the USA between 2020 and 2021. This paper documents the timing, characteristics, and heterogeneity of the change in immigration across states and economic sectors. Additionally, we describe the trends in internal native mobility in the USA prior to and after the pandemic, investigating whether natives responded to the decrease in immigration by relocating either geographically or across sectors. Despite the substantial drop in international migration, we do not observe any significant changes in native internal mobility. Employing a panel regression and a shift-share IV, we study the effect of foreign immigration, the emergence of remote-work, and changes in labor demand on cross-state native mobility. Our results indicate that the decline in immigration following COVID-19 and the differential availability of remote-work opportunities across sectors and states did not drive changes in natives’ cross- state or cross-sector mobility.