bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of laparoscopic and open ileocecal resection for Crohn’s disease in children
Authors: Dotlacil V. , Lerchova T. , Coufal S. , Kucerova B. , Schwarz J. , Hradsky O. , Skaba R. , Rygl M. 
Published: February 2023

Abstract
Purpose
Ileocecal resection (ICR) is the most frequently performed surgery in paediatric Crohn’s disease (CD) patients. The aim of the study was to compare laparoscopic-assisted and open ICR.

Methods
Retrospective review of consecutive CD patients undergoing ICR between March 2014 and December 2021 was performed. The patients were divided into open (OG) and laparoscopic (LG) groups. Compared parameters included patients’ demographics, clinical characteristics, surgery, duration of hospitalisation and follow-up. Complications were classified according to the Clavien–Dindo classification (CDc). Risk factors were identified using multivariable analysis.

Results
Sixty-two patients (29 females, 46.7%) were included in the analysis, forty-two patients in OG. The median duration of surgery was 130 in OG versus 148 in LG (p = 0.065) minutes. Postoperative complications were reported in 4 patients (12.1%). There was no significant difference in postoperative complications according to CDc (OG 7.14 vs LG 5%, p = 1). The median length of hospitalisation was 8 in OG and 7 days in LG (p = 0.0005). The median length of follow-up was 21.5 months.

Conclusion
The laparoscopic-assisted approach had shorter hospital stay and was not associated with increased risk of 30-day postoperative complications. Laparoscopic surgery should be considered the preferred surgical approach for primary ICR.
3D liver model-based surgical education improves preoperative decision-making and patient satisfaction—a randomized pilot trial
Authors: Giehl-Brown Esther , Dennler Sandra , Garcia Sebastián A. , Seppelt Danilo , Oehme Florian , Schweipert Johannes , Weitz Jürgen , Riediger Carina 
Published: February 2023

Abstract
Objective
Hepatobiliary surgery bares obstacles to informed consent for the patients due to its complexity and related risk of postoperative complications. 3D visualization of the liver has been proven to facilitate comprehension of the spatial relationship between anatomical structures and to assist in clinical decision-making. Our objective is to utilize individual 3D-printed liver models to enhance patient satisfaction with surgical education in hepatobiliary surgery.

Design, setting
We conducted a prospective, randomized pilot study comparing 3D liver model-enhanced (3D-LiMo) surgical education against regular patient education during preoperative consultation at the department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany.

Participants
Of 97 screened patients, undergoing hepatobiliary surgery, 40 patients were enrolled from July 2020 to January 2022.

Results
The study population (n = 40) was predominantly of male gender (62.5%) with a median age of 65.2 years and a high prevalence of preexisting diseases. Underlying disease, warranting hepatobiliary surgery, was malignancy in the majority of cases (97.5%). Patients in the 3D-LiMo group were more likely to feel very thoroughly educated and exhibited a higher level of satisfaction following surgical education than the control group (80 vs. 55%, n.s.; 90 vs. 65%, n.s.; respectively). Applying 3D models was also associated with enhanced understanding of the underlying disease with regard to amount (100% vs. 70%, p = 0.020) and location of liver masses (95 vs. 65%, p = 0.044). 3D-LiMo patients also demonstrated enhanced understanding of the surgical procedure (80 vs. 55%, n.s.), leading to better awareness for the occurrence of postoperative complications (88.9, vs. 68.4%, p = 0.052). Adverse event profiles were similar.

Conclusion
In conclusion, individual 3D-printed liver models increase patient satisfaction with surgical education and facilitate patients’ understanding of the surgical procedure as well as awareness of postoperative complications. Therefore, the study protocol is feasible to apply to an adequately powered, multicenter, randomized clinical trial with minor modifications.
Sodium-glucose cotransporter 2 inhibitor-associated perioperative ketoacidosis: a systematic review of case reports
Authors: Seki Hiroyuki , Ideno Satoshi , Shiga Toshiya , Watanabe Hidenobu , Ono Motoaki , Motoyasu Akira , Noguchi Hikari , Kondo Kazuya , Yoshikawa Takahiro , Hoshijima Hiroshi , Hyuga Shunsuke , Shishii Miho , Nagai Ai , Higashi Midoriko , Ouchi Takashi , Yasuda Kazuki , Kuratani Norifumi 
Published: February 2023

AbstractAlthough the recommended preoperative cessation period for sodium-glucose cotransporter 2 inhibitors (SGLT2is) changed in 2020 (from 24 h to 3–4 days preoperatively) to reduce the risk of SGLT2i-associated perioperative ketoacidosis (SAPKA), the validity of the new recommendation has not been verified. Using case reports, we assessed the new recommendation effectiveness and extrapolated precipitating factors for SAPKA. We searched electronic databases up to June 1, 2022 to assess SAPKA (blood pH < 7.3 and blood or urine ketone positivity within 30 days postoperatively in patients taking SGLT2i). We included 76 publications with 99 cases. The preoperative SGLT2i cessation duration was reported for 59 patients (59.6%). In all cases with available cessation periods, the SGLT2is were interrupted < 3 days preoperatively. No SAPKA cases with > 2-day preoperative cessation periods were found. Many case reports lack important information for estimating precipitating factors, including preoperative SGLT2i cessation period, body mass index, baseline hemoglobin A1c level, details of perioperative fluid management, and type of anesthesia. Our study suggested that preoperative SGLT2i cessation for at least 3 days could prevent SAPKA. Large prospective epidemiologic studies are needed to identify risk factors for SAPKA.
Mental health problems and suicidal behavior from adolescence to young adulthood in college: linking two population-based studies
Authors: Sivertsen Børge , O’Connor Rory C. , Nilsen Sondre Aasen , Heradstveit Ove , Askeland Kristin Gärtner , Bøe Tormod , Hysing Mari 
Published: February 2023

AbstractIt is well established that mental health problems are highly recurrent and persistent from childhood to adolescence, but less is known to what extent mental health problems also persist from adolescence into young adulthood. The aim of the current study was therefore to examine the chronicity and risk of mental health problems and suicidality from adolescence to young adulthood. Data stem from two Norwegian population-based studies conducted 6 years apart; the youth@hordaland study from 2012 (age 16–19) and the SHoT2018 study (age 22–25). These two data sources were linked to produce a longitudinal sample of 1257 individuals. A wide range of self-reported mental health and suicidality instruments (used both continuously and categorically) were analyzed using log-link binomial regression analysis, adjusting for age, sex, parental education, and financial problems. We found that high levels of mental health problems in late adolescence were a significant risk factor for reporting poor mental health 6 years later. Internalizing and externalizing problems in adolescence were associated with a 2.8-fold and 1.9-fold increased risk, respectively, of reporting a mental disorder 6 years later. Similarly, self-harm in adolescence was associated with a 2.1-fold increased risk of suicidal thoughts 6 years later. The magnitudes of the adjusted risk ratios were generally similar across the various mental health and suicidality measures used at the two assessment points. Adjustment for confounders did not, or only slightly, attenuate the risk ratios, and all associations remained statistically significant in the adjusted analyses. This longitudinal study provides new evidence of the chronicity of mental health problems and suicidality from adolescence to adulthood in Norway. The results emphasize the importance of early identification and timely interventions to reduce the prevalence and impact of mental health problems and suicidality.
Treatment of digital ulcers in systemic sclerosis: recent developments and future perspectives
Authors: Sagonas Ioannis , Daoussis Dimitrios 
Published: February 2023

AbstractDigital ulcers (DUs) comprise the main manifestation of vasculopathy and are a major cause of disability in patients with systemic sclerosis (SSc). A literature search in Web of Science, PubMed and Directory of Open Access Journals was performed in December 2022 to identify articles published in the last decade regarding the management of DUs. Prostacyclin analogues, endothelin antagonists and phosphodiesterase 5 inhibitors have shown promising results both as a stand-alone treatment and in combination for the treatment of existing and prevention of new DUs. Moreover, autologous fat grafting and botulinum toxin injections, although not readily available, can be of use in recalcitrant cases. Many investigational treatments with promising results could pave the way for a paradigm shift in the treatment of DUs in the future. Despite these recent advances, challenges remain. Better-designed trials are of paramount importance to optimise DU treatment in the years to come.

Key Points• DUs are a major cause of pain and reduced quality of life in patients with SSc.• Prostacyclin analogues and endothelin antagonists have shown promising results both as a stand-alone treatment and in combination for the treatment of existing and prevention of new DUs.• In the future, a combination of more powerful vasodilatory drugs, perhaps in conjunction with topical approaches, may improve outcomes.
Last twenty-years activity of cardiovascular tissue banking in Barcelona
Authors: Castells-Sala C. , Pérez M. L. , Agustí E. , Aiti A. , Tarragona E. , Navarro A. , Tabera J. , Fariñas O. , Pomar J. L. , Vilarrodona A. 
Published: February 2023

AbstractThe Barcelona Tissue Bank was established from the merge of two previous multi-tissue banks. Potential donors are screened by Donor Center staff and multi-tissue retrieval is performed by specialized own teams. Tissue processing and preservation is performed in clean room facilities by specialised personnel. After quality control of both donor and all tissues results, the heart valves and vascular segments are stored until medical request. The aim of this report is to present the cardiovascular tissue activity and retrospectively evaluate the outcomes of the changes performed in last 20 years. Cardiovascular tissue from 4088 donors was received, specifically 3115 hearts and 2095 vascular segments were processed and evaluated. A total of 48% of the aortic valves, 68% of the pulmonary valves and 75% of the vascular segments were suitable for transplant. The main reason for discarding tissue was macroscopic morphology followed by microbiological results, for both valves and arteries. Altogether, 4360 tissues were distributed for transplantation: 2032 (47%) vascular segments, 1545 (35%) pulmonary valves and 781 (18%) aortic valves. The most common indication for aortic valve surgery was the treatment of endocarditis, while for pulmonary valves, it was congenital malformation reconstruction. Vascular segments were mainly used for reconstruction after ischemia. During this period, a number of changes were made with the goal of enhancing tissue quality, safety and efficacy. These improvements were achieved through the use of a new antibiotic cocktail, increasing of donor age criteria and changing the microbiological control strategy.
Impact of storage time prior to cryopreservation on mechanical properties of aortic homografts
Authors: Axelsson Ida , Gustafsson Anna , Isaksson Hanna , Nilsson Johan , Malm Torsten 
Published: February 2023

AbstractOptimal time spans in homograft procurement are still debatable among tissue banks and needs to be further investigated. Cell viability decreases at longer preparation intervals, but the effect on collagen and elastic fibers has not been investigated to the same extent. These fibers are of importance to the homograft elasticity and strength. The objective of this study was to analyze the mechanical properties of homograft tissue at different time spans in the procurement process. Ten aortic homografts were collected at the Tissue Bank in Lund. Twelve samples were obtained from each homograft, cryopreserved in groups of three after 2–4 days, 7–9 days, 28–30 days, and 60–62 days in antibiotic decontamination. Mechanical testing was performed with uniaxial tensile tests, calculating elastic modulus, yield stress and energy at yield stress. Two randomly selected samples were assessed with light microscopy. Procurement generated a total of 120 samples, with 30 samples in each time group. Elastic modulus and yield stress was significantly higher in samples cryopreserved after 2–4 days (2.7 MPa (2.5-5.0) and 0.78 MPa (0.68-1.0)) compared to 7–9 days (2.2 MPa (2.0-2.6) and 0.53 MPa (0.46–0.69)), p = 0.008 and 0.011 respectively. Light microscopy did not show any difference in collagen and elastin at different time spans. There was a significant decrease in elastic modulus and yield stress after 7 days of decontamination at 4 °C compared to 2–4 days. This could indicate some deterioration of elastin and collagen at longer decontamination intervals. Clinical significance of these findings remains to be clarified.
Seasonal and diurnal patterns of littoral microhabitat use by fish in gravel pit lakes, with special reference to supplemented deadwood brush piles
Authors: Maday A. , Matern S. , Monk C. T. , Klefoth T. , Wolter C. , Arlinghaus R. 
Published: February 2023

AbstractThe habitat quality of the littoral zone is of key importance for almost all lentic fish species. In anthropogenically created gravel pit lakes, the littoral zone is often structurally homogenized with limited fish habitats. We supplemented deadwood brush piles in the littoral zone of eight gravel pit lakes and investigated the diurnal and seasonal use of this and other typical microhabitats by six dominant fish species. Shoreline habitats were sampled using point abundance electrofishing during day and night in all four seasons, and patterns of fish abundance were compared amongst unstructured littoral habitats, emerged macrophytes and brush piles. We caught a total of 14,458 specimens from 15 species in the gravel pit lakes. Complex shoreline structures were used by all fish species that we examined, especially during daytime, whilst the use of unstructured habitats was highest during night. The newly added brush piles constituted suitable microhabitats for selected fish species, perch (Perca fluviatilis), roach (Rutilus rutilus) and pike (Esox lucius), particularly during winter. Supplemented deadwood provides suitable fish habitat in gravel pit lakes and may to some degree compensate for the loss of submerged macrophytes in winter by offering refuge and foraging habitat for selected fish species.
Seasonal Differences in the Encounter Rate of the Fat-Tailed Dwarf Lemur (Cheirogaleus medius) in the Transitional Forests of Northwest Madagascar: Implications for Reliable Population Density Assessment
Authors: Hending Daniel , Randrianarison Heriniaina , Andriamavosoloarisoa Niaina Nirina Mahefa , Ranohatra-Hending Christina , Solofondranohatra James Sedera , Tongasoa Haja Roger , Ranarison Herinirina Tahina , Gehrke Victoria , Andrianirina Natacha , Holderied Marc , McCabe Grainne , Cotton Sam 
Published: February 2023

AbstractPrimate encounter rates often vary throughout the year due to seasonal differences in activity, ecology, and behaviour. One notably extreme behaviour is continuous hibernation. Although a rare adaptation in primates, the dwarf lemurs of Madagascar (genusCheirogaleus) enter obligate hibernation each year during the dry season, after spending the wet season consuming high-energy foods. Whilst seasonal changes in activity in someCheirogaleuspopulations are well-known, many species remain little-studied, and there is no specific information on their encounter rates, nor when they enter and emerge from hibernation. This uncertainty critically affects reliable calculation of population density estimates for these highly threatened lemurs. In this study, we assessed how encounter rates of the fat-tailed dwarf lemur (C. medius) vary seasonally in the transitional forests of the Sahamalaza-Iles Radama National Park, northwest Madagascar, during a 4-year period. We established a system of line transects (N = 60) throughout our study area, on which we conducted distance sampling ofC. medius. We then used our distance sampling data to calculate encounter rate and population density data. We found encounter rates ofC. mediusto be significantly higher during the wet season compared with the dry season. Furthermore, encounter rates ofC. mediuswere particularly low from May–August. These results provide some evidence to suggest the time period thatC. mediushibernate in Sahamalaza-Iles Radama National Park. These findings underpin the importance of careful study design when surveying threatened species with seasonal differences in activity, such as those that hibernate. This study also demonstrates the importance of species-specific behavioural data for accurate population density assessment, which is required to inform conservation action.
Integrated Mental Healthcare and Vocational Rehabilitation for People on Sick Leave with Anxiety or Depression: 24-Month Follow-up of the Randomized IBBIS Trial
Authors: Hoff Andreas , Poulsen Rie Mandrup , Fisker Jonas Peter , Hjorthøj Carsten , Nordentoft Merete , Christensen Ulla , Bojesen Anders Bo , Eplov Lene Falgaard 
Published: February 2023

AbstractIntegration of vocational rehabilitation and mental healthcare has shown some effect on work participation at 1-year follow-up after sick leave with depression and anxiety. We aimed to study the effect on work and health outcomes at 2-year follow-up, why we performed a randomized trial was conducted to study the effectiveness of integrated intervention (INT) compared to service as usual (SAU) and best practice mental healthcare (MHC). We included 631 participants, and at 24-month follow-up, we detected no differences in effect between INT and SAU. Compared to MHC, INT showed faster return-to-work (RTW) rates (p = 0.044) and a higher number of weeks in work (p = 0.024). No symptom differences were observed between the groups at 24 months. In conclusion, compared to SAU, INT was associated with a slightly higher work rate reaching borderline statistical significance at 12-month follow-up and lower stress levels at 6-month follow-up. The disappearance of relative effect between 12 and 24 months may be explained by the fact that the intervention lasted less than 12 months or by delayed spontaneous remission in the SAU group after 12 months. Despite the lack of effect at long-term follow-up, INT still performed slightly better than SAU overall. Moderate implementation difficulties, may partly explain the absence of the hypothesized effect. Integrated intervention, as implemented in this trial, showed some positive effects on mid-term vocational status and short-term stress symptom levels. However, these effects were not sustained beyond the duration of the intervention.
Spatial predictions for the distribution of woody plant species under different land-use scenarios in southwestern Ethiopia
Authors: Duguma Dula Wakassa , Law Elizabeth , Shumi Girma , Rodrigues Patrícia , Senbeta Feyera , Schultner Jannik , Abson David J. , Fischer Joern 
Published: February 2023

Abstract
Context
Deforestation, forest degradation and intensification of farming threaten terrestrial biodiversity. As these land-use changes accelerate in many landscapes, especially in the Global South, it is vital to anticipate how future changes might impact specific aspects of biodiversity.

Objectives
The objectives of this study were to model woody plant species richness in southwestern Ethiopia, for the present and for four plausible, spatially explicit scenarios of the future (‘Gain over grain’, ‘Mining green gold’, ‘Coffee and conservation’ and ‘Food first’).

Methods
We used cross-validated generalized linear models for both forest and farmland, to relate empirical data on total and forest-specialist woody plant species richness to indicators of human disturbance and environmental conditions. We projected these across current and future scenario landscapes.

Results
In both farmland and forest, richness peaked at intermediate elevations (except for total species richness in farmland) and decreased with distance to the forest edge (except for forest specialist richness in forest). Our results indicate that the ‘Mining green gold’ and ‘Food first’ scenarios would result in strong losses of biodiversity, whereas the ‘Gain over grain’ scenario largely maintained biodiversity relative to the baseline. Only the ‘Coffee and conservation’ scenario, which incorporates a new biosphere reserve, showed positive changes for biodiversity that are likely viable in the long term.

Conclusions
The creation of a biosphere reserve could maintain and improve woody plant richness in the focal region, by forming a cluster with existing reserves, would be a major step forward for sustainability in southwestern Ethiopia.
“Your struggles are valid, you are worthy of help and you deserve to recover”: narratives of recovery from orthorexia nervosa
Authors: Talbot Catherine V. , Campbell Charleigh E. R. , Greville-Harris Maddy 
Published: February 2023

Abstract
Purpose
Limited research has examined recovery processes and conceptualisations of recovery within orthorexia nervosa (ON). This study harnessed Instagram data to examine how people who self-identify with ON use the hashtag #OrthorexiaRecovery and how recovery is represented within this online space.

Methods
500 textual posts containing #OrthorexiaRecovery were extracted from Instagram. Co-occurring hashtags were analysed descriptively to determine whether this online space is specific to ON, and textual data were analysed using reflexive thematic analysis.

Results
The hashtag analysis indicated that #OrthorexiaRecovery is being used within a wider context of eating disorder recovery and awareness, but also provides deep insights into experiences of recovery from ON. The thematic analysis generated five themes: the invisibility of orthorexia; a turbulent and continuous process; finding food freedom; from compulsive exercise to intuitive movement; a community of support. Our findings suggest that people with self-reported ON experience recovery as a continuous process and the current invisibility of ON within diagnostic criteria and wider society impedes recovery. While working towards recovery, users aimed to be free from diet culture, become more attuned to their bodies, and develop more adaptive relationships with food and fitness. Users noted a general lack of support for people with ON and so used this online space to create a supportive community, though some content was potentially triggering.

Conclusion
Our findings highlight the importance of increased recognition of ON and the potential value of targeting societal norms and harnessing social identity resources within therapeutic interventions for ON.
Rheuma nach COVID-19-Infektion oder Impfung
Authors: Herold Manfred 
Published: February 2023

ZusammenfassungSowohl nach COVID-Infektion als auch nach ein oder mehreren COVID-Impfungen können rheumatische Beschwerden beginnen. In beiden Fällen scheint der Mechanismus ähnlich zu sein und mit dem Coronavirus oder seinen spezifischen Folgen zusammenzuhängen. Zumeist wird von einer reaktiven Arthritis gesprochen, wenngleich die Bezeichnung COVID-19-assoziierte Arthritis für das Beschwerdebild eher zutreffen dürfte. In Relation zur Zahl der COVID-Infizierten und der COVID-geimpften ist die Zahl der Fälle, in denen es zu COVID-assoziierten Beschwerden kommt, außerordentlich gering und die Prognose scheint eher gut zu sein.