bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between coronary flow and aortic stenosis during transcatheter aortic valve implantation
Authors: Suzuki Wataru , Nakano Yusuke , Ando Hirohiko , Fujimoto Masanobu , Sakurai Hikaru , Suzuki Mayu , Takahashi Hiroshi , Mukai Kentaro , Amano Tetsuya 
Published: April 2023

AbstractAimsIn patients with aortic stenosis (AS), the coronary flow reserve decreases even in the absence of epicardial coronary artery stenosis. Systolic coronary flow reversal (SFR) reflecting reduced coronary microcirculation, often seen in patients with severe AS, has a potential negative impact on the pathogenesis of cardiac dysfunction. However, there are limited data on the relationship between the severity of AS and SFR, as well as on the benefits of transcatheter aortic valve implantation (TAVI). The aim of this study was to evaluate the relationship between the severity of AS and efficacy of TAVI in improving SFR.Methods and resultsConsecutive patients with AS who had undergone TAVI using transoesophageal echocardiography (TEE) from November 2020 to February 2022 were prospectively enrolled. Coronary flow in the left anterior descending artery as well as the aortic valve peak velocities, and the mean aortic valve pressure gradients (AVPGs), indicating the severity of AS, were measured using intraprocedural TEE before and after TAVI. The following parameters were measured as coronary flow: systolic and diastolic peak velocity (cm/s) and systolic and diastolic velocity‐time integral (VTI) (cm). SFR was defined as the presence of a reversal coronary flow component in systole. The enrolled patients were classified into two groups according to the presence or absence of SFR before TAVI. A total of 25 patients were included: 13 had SFR and 12 who had no SFR, before TAVI. Patients with SFR had significantly higher aortic valve peak velocities (451.1 ± 45.9 vs. 372.1 ± 52.1 cm/s; P < 0.001) and mean AVPGs (49.2 ± 14.5 vs. 30.3 ± 11.6 mmHg; P = 0.002) than those without. The optimal binary cut‐off aortic valve peak velocity values and the mean AVPG associated with the presence of SFR before TAVI were >410.0 cm/s (specificity, 75.0%; sensitivity, 92.3%) and >37.4 mmHg (specificity, 83.3%; sensitivity, 92.3%), respectively. After TAVI, SFR immediately disappeared in 11 of 13 patients with SFR (84.6%). Overall, the systolic coronary VTI significantly increased after TAVI (2.0 ± 4.7 vs. 6.4 ± 3.2 cm, P < 0.001), and this increase was greater in patients with SFR than in those without SFR before TAVI (interaction P = 0.035).ConclusionsSFR was found to be associated with the severity of AS and with a greater increase in systolic coronary flow immediately after TAVI.
Implementation of particle swarm optimization strategy in Venlo‐type greenhouse climate to make energy‐efficient process
Authors: Kaur Arshdeep , Sonawane Vijay , Gandhewar Nisarg , Rosha Pali 
Published: April 2023

AbstractThis study appears to be the first to use a MATLAB simulator to illustrate Particle Swarm Optimization with multiple input–output restrictions. This proposed study's overarching objective was to make the entire process energy efficient, which provides improved performance with high accuracy and minimizes the operating cost by incorporating energy, ventilation, and CO2. Further, to reduce the complexity of the system, the optimization technique was divided into control and controlled variables. Meanwhile, to define state constraints for variables used in the objective function was to make the overall process cost‐effective, composing energy, CO2 supply, and ventilation cost. The chosen technique effectively decreased operating costs while maintaining the appropriate ranges for temperature (14–26°C), relative humidity (0–90%), and CO2 concentration (400–2000 ppm), according to simulation results. Off‐peak, standard, and peak energy cost levels were R1080.26, R748.56, and R7078.4, respectively. On the other hand, it was found through comparative analysis that the standard and off‐peak energy consumption figures decreased by 65.4 and 8.1%, respectively, as compared to the peak tariff (2279.9 kWh). The suggested PSO technique is implied to be a viable means of increasing greenhouse energy efficiency and achieving sustainable, cleaner manufacturing.
Studies of Endocrine Disruptors: Nonylphenol and Isomers in Biological Models
Authors: De la Parra-Guerra Ana C. , Acevedo-Barrios Rosa 
Published: April 2023

Abstract
Certain emerging pollutants are among the most widely used chemicals globally, causing widespread concern in relation to their use in products devoted to cleaniness and asepsis. Nonylphenol ethoxylate (NPEOn) is one such contaminant, along with its degradation product, nonylphenol, an active ingredient presents in nonionic surfactants used as herbicides, cosmetics, paints, plastics, disinfectants, and detergents. These chemicals and their metabolites are commonly found in environmental matrices. Nonylphenol and NPEOn, used, are particularly concerning, given their role as endocrine disruptors chemical and possible neurotoxic effects recorded in several biological models, primarily aquatic organisms. Limiting and detecting these compounds remain of paramount importance. The objective of the present review was to evaluate the toxic effects of nonylphenol and NPEOn in different biological models. Environ Toxicol Chem 2023;42:1439–1450. © 2023 SETAC
Using exogenous organizational and regional hospital attributes to explain differences in case‐mix adjusted hospital costs
Authors: Havranek Michael M. , Ondrej Josef , Widmer Philippe K. , Bollmann Stella , Spika Simon , Boes Stefan 
Published: April 2023

AbstractDiagnosis‐related group (DRG) hospital reimbursement systems differentiate cases into cost‐homogenous groups based on patient characteristics. However, exogenous organizational and regional factors can influence hospital costs beyond case‐mix differences. Therefore, most countries using DRG systems incorporate adjustments for such factors into their reimbursement structure. This study investigates structural hospital attributes that explain differences in average case‐mix adjusted hospital costs in Switzerland. Using rich patient and hospital‐level data containing 4 million cases from 120 hospitals across 3 years, we show that a regression model using only five variables (number of discharges, ratio of emergency/ambulance admissions, rate of DRGs to patients, expected loss potential based on DRG mix, and location in large agglomeration) can explain more than half of the variance in average case‐mix adjusted hospital costs, capture all cost variations across commonly differentiated hospital types (e.g., academic teaching hospitals, children's hospitals, birth centers, etc.), and is robust in cross‐validations across several years (despite differing hospital samples). Based on our findings, we propose a simple practical approach to differentiate legitimate from inefficiency‐related or unexplainable cost differences across hospitals and discuss the potential of such an approach as a transparent way to incorporate structural hospital differences into cost benchmarking and payment schemes.
Effect of correlated color temperature and illuminance on sustained attention collected via electroencephalography signals
Authors: Fu Xiaoyun , Feng Di , Xu Jiang 
Published: April 2023

AbstractThis study aimed to explore the differences in the subjects' sustained attention under the impact of nine lighting conditions consisting of the combination of three commonly used correlated color temperature (CCT) (3300 K, 4300 K, and 5300 K) and illuminance levels (300 lx, 500 lx, and 750 lx) to provide guidance on the adjustment of CCT and illuminance level parameters for indoor lighting. We selected 24 physically and mentally healthy university students (12 male and 12 female) as the experimental subjects. The subjects were required to perform sustained attention to response task (SART) activities under the nine different lighting conditions and collected the alpha (α) waves (8–12 Hz) from the electroencephalography signals. Subsequently, the mean power spectral density of the α waves and various SART parameters were analyzed and tested. Finally, the effects of different CCT and illuminance levels on the subjects' attention were compared. With the increase in CCT, the attention level tended to increase linearly, whereas the attention level was the lowest at 300 lx and the highest at 500 lx and appeared as an inverted “U” shape. The subjects' attention level was the highest at the combination of CCT of 5300 K and illuminance level of 500 lx and the lowest at the combination of CCT of 3300 K and illuminance level of 500 lx. These results provide important data to elucidate the impact of lighting condition on attention.
Significant reduction in the incidence of non‐coronavirus infections in patients with chronic lymphocytic leukemia on ibrutinib and venetoclax treatment during the COVID‐19 pandemic: An additional benefit of lockdown
Authors: Kislova Maria , Petrenko Andrei , Dmitrieva Elena A. , Milenkin Alexander , Nikitin Konstantin E. , Ptushkin Vadim V. , Shabunin Alexey V. , Nikitin Eugene A. 
Published: April 2023

AbstractEffective treatment and prevention of infections challenge management of patients with chronic lymphicytic leukemia (CLL). The COVID‐19 pandemic resulted in the reduction of outpatient hospital visits as a part of non‐pharmaceutical interventions that could affect the incidence of infectious complications. Study enrolled patients with CLL receiving ibrutinib or/and venetoclax who were observed at the Moscow City Centre of Hematology from 01 April 2017 to 31 March 2021. We found a reduction in the incidence of infectious episodes after the implementation of the lockdown in Moscow in 01 April 2020, when compared to data on the year prior to the lockdown (p < 0.0001), as well as when compared to the predictive model (p = 0.02), and based on individual infection profiles using cumulative sums (p < 0.0001). Bacterial infections had 4.44‐fold decrease, bacterial in combination with undefined infections had 4.89‐fold decrease, viral infections had unsignificant changes. The decrease in the number of outpatient visits coincides with the time of the lockdown could be a likely factor, explaining a decline in the incidence of infection. Patients were clustered according incidence and severity of infectious episodes for subgroup mortality assessment. No differences in overall survival due to COVID‐19 were observed. Typical respiratory infections, bacterial and undefined, the transmission of which may be affected by patient‐to‐patient contact in the settings of out‐patient health care visits were decreased, possibly due to SARS‐CoV‐2 restrictive measures. A positive correlation between outpatient visits and the incidence of bronchial and upper respiratory tract infection points at the role of hospital‐acquired infection and attests to the necessity of reorganizing care for all patients with CLL.
The potential role of scavenger receptor B type I (SR‐BI) in SARS‐CoV‐2 infection
Authors: Alkazmi Luay , Al‐kuraishy Hayder M. , Al‐Gareeb Ali I. , Alexiou Athanasios , Papadakis Marios , Saad Hebatallah M. , Batiha Gaber El‐Saber 
Published: April 2023

AbstractScavenger receptor type B I (SR‐BI), the major receptor for high‐density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane. SR‐BI is implicated as a receptor for entry of severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2). SR‐BI is colocalized with the angiotensin‐converting enzyme 2 (ACE2) increasing the binding and affinity of SARS‐CoV‐2 to ACE2 with subsequent viral internalization. SR‐BI regulates lymphocyte proliferation and the release of pro‐inflammatory cytokines from activated macrophages and lymphocytes. SR‐BI is reduced during COVID‐19 due to consumption by SARS‐CoV‐2 infection. COVID‐19‐associated inflammatory changes and high angiotensin II (AngII) might be possible causes of repression of SR‐BI in SARS‐CoV‐2 infection. In conclusion, the downregulation of SR‐BI in COVID‐19 could be due to direct invasion by SARS‐CoV‐2 or through upregulation of pro‐inflammatory cytokines, inflammatory signaling pathways, and high circulating AngII. Reduction of SR‐BI in COVID‐19 look like ACE2 may provoke COVID‐19 severity through exaggeration of the immune response. Further studies are invoked to clarify the potential role of SR‐BI in the pathogenesis of COVID‐19 that could be protective rather than detrimental.
Global trends in the treatment of local public entities in distress: A principled approach
Authors: Coordes Laura N. , Marique Yseult , Vaccari Eugenio 
Published: April 2023

AbstractThis article presents the findings of a global study on the treatment of local public entities in distress conducted in 20 jurisdictions across the world. It sets out to detail and analyses how different national insolvency law systems treat local public entities in distress. The main purpose of this study is to provide recommendations for a harmonised and principled treatment of these entities. The key priority of the recommendations proposed in the study is to ensure the continuity of essential public services without necessarily deviating from the established insolvency principles of collectivity and equality of treatment among creditors.
Strategies for Competitive Activity‐Based Protein Profiling in Small Molecule Inhibitor Discovery and Characterization
Authors: Zhu He , Sharafi Mona , Teh Wei Pin , Bratt Ariana S. , Buhrlage Sara J. , Marto Jarrod A. 
Published: April 2023

AbstractSince its introduction by Cravatt and colleagues in 1999, activity‐based protein profiling (ABPP) has become widely utilized throughout academia, government, and industry laboratories to study enzymes spanning numerous gene families in a multitude of biological systems. As a variation of ABPP, competitive ABPP provides a powerful approach to characterize the binding behavior of small molecule probes and clinical drugs throughout the functional proteome. The power and flexibility of competitive ABPP are exemplified by a wide range of creative adaptions which increase assay throughput, enable diverse detection schemes, and support the implementation of this approach within a hybrid target‐based screening platform. We review major developments in competitive ABPP through a compare‐contrast format to provide a useful introduction to this enabling technology for scientists in chemical biology and drug discovery.
Inhibitory interaction of flavonoids with organic cation transporter 2 and their structure–activity relationships for predicting nephroprotective effects
Authors: Tan Huixin , Wang Fenghe , Hu Jiahuan , Duan Xiaoyan , Bai Wanting , Wang Xinbo , Wang Baolian , Su Yan , Hu Jinping 
Published: April 2023

AbstractOrganic cation transporter 2 (OCT2) is mainly responsible for the renal secretion of various cationic drugs, closely associated with drug‐induced acute kidney injury (AKI). Screening and identifying potent OCT2 inhibitors with little toxicity in natural products in reducing OCT2‐mediated AKI is of great value. Flavonoids are enriched in various vegetables, fruits, and herbal products, and some were reported to produce transporter‐mediated drug–drug interactions. This study aimed to screen potential inhibitors of OCT2 from 96 flavonoids, assess the nephroprotective effects on cisplatin‐induced kidney injury, and clarify the structure–activity relationships of flavonoids with OCT2. Ten flavonoids exhibited significant inhibition (>50%) on OCT2 in OCT2‐HEK293 cells. Among them, the six most potent flavonoid inhibitors, including pectolinarigenin, biochanin A, luteolin, chrysin, 6‐hydroxyflavone, and 6‐methylflavone markedly decreased cisplatin‐induced cytotoxicity. Moreover, in cisplatin‐induced renal injury models, they also reduced serum blood urea nitrogen (BUN) and creatinine levels to different degrees, the best of which was 6‐methylflavone. The pharmacophore model clarified that the aromatic ring, hydrogen bond acceptors, and hydrogen bond donors might play a vital role in the inhibitory effect of flavonoids on OCT2. Thus, our findings would pave the way to predicting the potential risks of flavonoid‐containing food/herb–drug interactions in humans and optimizing flavonoid structure to alleviate OCT2‐related AKI.
Performance of point‐of‐care severity scores to predict prognosis in patients admitted through the emergency department with COVID‐19
Authors: Prasad Priya A. , Correia Jessica , Fang Margaret C. , Fisher Arielle , Correll Mick , Oreper Sandra , Auerbach Andrew 
Published: April 2023

AbstractBackgroundIdentifying COVID‐19 patients at the highest risk of poor outcomes is critical in emergency department (ED) presentation. Sepsis risk stratification scores can be calculated quickly for COVID‐19 patients but have not been evaluated in a large cohort.ObjectiveTo determine whether well‐known risk scores can predict poor outcomes among hospitalized COVID‐19 patients.Designs, Settings, and ParticipantsA retrospective cohort study of adults presenting with COVID‐19 to 156 Hospital Corporation of America (HCA) Healthcare EDs, March 2, 2020, to February 11, 2021.InterventionQuick Sequential Organ Failure Assessment (qSOFA), Shock Index, National Early Warning System‐2 (NEWS2), and quick COVID‐19 Severity Index (qCSI) at presentation.Main Outcome and MeasuresThe primary outcome was in‐hospital mortality. Secondary outcomes included intensive care unit (ICU) admission, mechanical ventilation, and vasopressors receipt. Patients scored positive with qSOFA ≥ 2, Shock Index > 0.7, NEWS2 ≥ 5, and qCSI ≥ 4. Test characteristics and area under the receiver operating characteristics curves (AUROCs) were calculated.ResultsWe identified 90,376 patients with community‐acquired COVID‐19 (mean age 64.3 years, 46.8% female). 17.2% of patients died in‐hospital, 28.6% went to the ICU, 13.7% received mechanical ventilation, and 13.6% received vasopressors. There were 3.8% qSOFA‐positive, 45.1% Shock Index‐positive, 49.8% NEWS2‐positive, and 37.6% qCSI‐positive at ED‐triage. NEWS2 exhibited the highest AUROC for in‐hospital mortality (0.593, confidence interval [CI]: 0.588–0.597), ICU admission (0.602, CI: 0.599–0.606), mechanical ventilation (0.614, CI: 0.610–0.619), and vasopressor receipt (0.600, CI: 0.595–0.604).ConclusionsSepsis severity scores at presentation have low discriminative power to predict outcomes in COVID‐19 patients and are not reliable for clinical use. Severity scores should be developed using features that accurately predict poor outcomes among COVID‐19 patients to develop more effective risk‐based triage.
Varietal identification in pasta through an SSR‐based approach: a case study
Authors: Fanelli Valentina , Dellino Maria , Taranto Francesca , De Giovanni Claudio , Sabetta Wilma , De Vita Pasquale , Montemurro Cinzia 
Published: April 2023

AbstractBACKGROUNDPasta is a worldwide popular Italian food made exclusively of durum wheat. The choice of variety to be used to produce pasta is at the discretion of the producer based on the peculiar characteristics of each cultivar. The availability of analytical approaches for the tracking of specific varieties along the productive chain is becoming increasingly important to authenticate the pasta products and distinguish between fraudulent activities and cross‐contaminations during the production process. Among the different methods, molecular approaches based on DNA markers are the most used for these purposes because of their ease of use and high reproducibility.RESULTSIn the present study, we used an easy simple sequence repeats‐based method to identify the durum wheat varieties used to produce 25 samples of semolina and commercial pasta comparing their molecular profile with those of the four varieties declared by the producer and other 10 durum wheat cultivars commonly used in pasta production. All of the samples showed the expected molecular profile; however, most of them present also a foreign allele indicating a possible cross‐contamination. Moreover, we evaluated the accuracy of the proposed approach through the analysis of 27 hand‐made mixtures with increasing amounts of a specific contaminant variety, allowing the estimation of the limit of detection of 5% (w/w).CONCLUSIONWe demonstrated the feasibility of the proposed method and its effectiveness in the detection of not declared varieties when these are present in a percentage equal to or higher than 5%. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Effect of different botanically‐diverse diets on the fatty acid profile, tocopherol content and oxidative stability of beef
Authors: Kearns Michelle , Jacquier Jean‐Christophe , Harrison Sabine M , Cama‐Moncunill Raquel , Boland Tommy M , Sheridan Helen , Kelly Alan K , Grasso Simona , Monahan Frank J 
Published: April 2023

AbstractBACKGROUNDBeef from pasture‐fed animals is viewed as a healthier and more welfare‐friendly alternative to concentrate‐fed beef. Botanically‐diverse pastures consisting of numerous plant species may alter the fatty acid (FA) profile and the tocopherol content of beef, as well as the oxidative stability of the meat. In the present study, steers were assigned to one of three botanically‐diverse diets: perennial ryegrass (PRG), perennial ryegrass + white clover (PRG + WC) or multi‐species (MS), all with a finishing diet of the respective botanically‐diverse silages plus a cereal‐based concentrate, consistent with production systems in Ireland. The FA profile, tocopherol content, oxidative stability and colour of meat during storage were measured.RESULTSCompared to the other diets, the MS diet resulted in higher proportions of linolenic acid (C18:3n‐3c), linoleic acid (C18:2n‐6c) and total polyunsaturated fatty acids (PUFA), with higher PUFA:saturated fatty acid and n‐6:n‐3 ratios in the meat. α‐Tocopherol concentrations were lowest in the meat of animals from the MS diet. In uncooked meat, lipid oxidation and colour values were affected by storage time across all diets, whereas the MS diet led to higher hue values only on day 14 of storage. When cooked, meat from animals on PRG + WC and MS diets had higher lipid oxidation on days 1 and 2 of storage than meat from animals on the PRG diet.CONCLUSIONFeeding steers on a botanically‐diverse diet consisting of six plant species can improve the n‐3 FA and PUFA concentration of beef, affecting the susceptibility of cooked, but not uncooked, beef to oxidation. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Widely Tunable (2.47–2.64 µm) Hybrid Laser Based on GaSb/GaInAsSb Quantum‐Wells and a Low‐Loss Si3N4 Photonic Integrated Circuit
Authors: Ojanen Samu‐Pekka , Viheriälä Jukka , Zia Nouman , Koivusalo Eero , Hilska Joonas , Tuorila Heidi , Guina Mircea 
Published: April 2023

AbstractPhotonic integrated circuits fabricated using a Si3N4 waveguide platform exhibit low losses in a wide wavelength region extending from visible to beyond 2 µm. This feature is exploited to demonstrate a high‐performance integrated laser exhibiting broad wavelength tuneability near a 2.6 µm wavelength region. The laser is based on a Si3N4 photonic integrated circuit incorporating a tunable reflector and a AlGaInAsSb/GaSb quantum‐well gain element. A tuning range of 170 nm (2474–2644 nm) and single‐mode CW operation with a maximum power of 6.4 mW at room temperature are demonstrated. The performance is enabled by exploitation of several essential building blocks realized in Si3N4, namely low‐loss Y‐branches, inverse tapers, and a double‐ring resonator with a free spectral range of ≈160 nm. Moreover, the limits of wavelength coverage are explored using Si3N4 waveguides and show that the platform supports low propagation loss up to 3.5 µm. Finally, the possibility to achieve improved mode matching between Si3N4 and GaSb waveguides is analyzed, further enabling enhancing the performance of such a hybrid laser platform and supporting wavelength extension beyond a 3 µm range.