bluuebunny/crossref_metadata_2025_split huggingface dataset:
Z-scheme MIL-125 (Ti)@Graphene Oxide composite photocatalysts with enhanced photocatalytic activity and stability for Tetracycline degradation
Authors: Tang Jijun , Gao Guicheng , Luo Weiqi , Dai Qiuyang , Wang Yuchen , Elzilal Hala A. , Abo-Dief Hala M. , Algadi Hassan , Zhang Jiaoxia 
Published: September 2023

Abstract
Domestic wastewater contains trace amounts of organic pollutants that are difficult to remove, such as antibiotics and dyes, so effective degradation technologies need to be found. Therefore, we report the fabrication of a novel Z-scheme MIL-125(Ti)/GO photocatalyst by an in-situ growing method. The photodegradation experiment showed that MIL-125(Ti)/GO degraded TC by 81.1% at 5% GO addition, which is 1.7 and 3.8 times higher than MIL-125(Ti) and GO, respectively. The degradation rate reached 0.0201 min-1, 3.3 times and 8.1 times higher than MIL-125(Ti) and GO, respectively. The study shows that GO and MIL-125(Ti), as electron donor and electron acceptor, respectively, form a Z-scheme heterojunction structure, which effectively improves the photocatalytic performance of MIL-125(Ti). MIL-125(Ti)/GO has excellent structural stability and reusable availability, and the main reactive radical are ·O-2 and h+. This study provides new insights into the design and fabrication of MIL-125(Ti) derivatives as photodegrading organic pollutants.
ChatGPT-4 and Wearable Device Assisted Intelligent Exercise Therapy for Co-existing Sarcopenia and Osteoarthritis (GAISO): A feasibility study and design for a randomized controlled PROBE non-inferiority trial
Authors: Li Jian , You Mingke , Chen Xi , Li Pengcheng , Deng Qian , Wang Kexin , Wang Li , Xu Yang , Liu Di , Ye Lin , Chen Gang , Liu Weizhi 
Published: September 2023

Abstract
Background
Sarcopenia and osteoarthritis are prevalent age-related diseases that mutually exacerbate each other, creating a vicious cycle that worsens both conditions. Exercise is key to breaking this detrimental cycle. Facing increasing demand for rehabilitation services within this patient demographic, ChatGPT-4 and wearable device may increase the availability, efficiency and personalization of such health care.
Aim
To evaluate the clinical efficacy and cost-effectiveness of a rehabilitation system implemented on mobile platforms, utilizing the integration of ChatGPT-4 and wearable devices.
Methods
The study design is a prospective randomized open blinded end-point (PROBE) non-inferiority trial. 278 patients diagnosed with osteoarthritis and sarcopenia will be recruited and randomly assigned to the intervention group and the control group. In the intervention group patients receive mobile phone-based rehabilitation service where ChatGPT-4 generates personalized exercise therapy, and wearable device guides and monitor the patient to implement the exercise therapy. Traditional clinic based face-to-face exercise therapy will be prescribed and implemented in the control group. All patients will receive three-months exercise therapies following the FITT-VP principle. The patients will be assessed at baseline, one month, three months, and six months after initiation. Outcome measures will include ROM, gait patterns, Visual Analogue Scale (VAS) for pain assessment, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS) for functional assessment, Short-Form Health Survey 12 (SF-12) for quality of life, Minimal Clinically Important Difference (MCID), Patient Acceptable Symptom State (PASS), and Substantial Clinical Benefit (SCB) for clinically significant measures.
Discussion
A rehabilitation system combining the capabilities of ChatGPT-4 and wearable devices potentially enhance the availability and efficiency of professional rehabilitation services, thus enhancing the therapeutic outcomes for a substantial population concurrently afflicted with sarcopenia and osteoarthritis.
Trial registration
This study has been registered on the Chinese Clinical Trial Registry. Registration number: ChiCTR2300069515.
Reliability and Validity of the Turkish Version of the COVID-19 Anxiety Syndrome Scale among Health Professionals
Authors: Arkan Burcu , Bostanlı Aylin , Bektaş Murat 
Published: September 2023

Abstract
Background: COVID-19 negatively affected people's lives in many ways. The aim of this study was to adapt the COVID-19 Anxiety Syndrome Scale (C-19ASS), used as reference to take measures against anxiety, worry, perceived threat and stressors, into Turkish and to test its reliability and validity on healthcare workers.
Methods: The sample of the methodological-descriptive-cross-sectional study consisted of 223 health care workers aged 18 years and above. "Sociodemographic Data Collection Form" and "COVID-19 Anxiety Syndrome Scale (C-19ASS) were used to obtain the data. Healthcare workers working in different cities and hospitals answered the questionnaires online using a link.
Results: The fit index of the scale was above 0.80 on both I-CVI and S-CVI basis. The results of the content validity analysis showed that the scale provided both content and language validity for the Turkish sample as well as measuring the subject matter as adequately as its original version with respect to the Turkish sample.
Conclusions: These findings support by showing that the Anxiety Syndrome Scale will be useful with mental status assessment and mental health services planning.
Formulation and optimization of pH-sensitive nanocrystals for improved oral delivery.
Authors: Lucía Lopez-Vidal , Pedro Parodi , Romanela Actis Maribel , Nahuel Camacho , Real Daniel Andrés , Fernando Irazoqui , Pablo Real Juan , Palma Santiago Daniel 
Published: September 2023

Abstract
The challenge of low water solubility in pharmaceutical science profoundly impacts drug absorption and therapeutic effectiveness. Nanocrystals (NC), consisting of drug molecules and stabilizing agents, offer a promising solution to enhance solubility and control release rates. In the pharmaceutical industry, top-down techniques are favored for their flexibility and cost-effectiveness. However, increased solubility can lead to premature drug dissolution in the stomach, which is problematic due to the acidic pH or enzymes. Researchers are exploring encapsulating agents that facilitate drug release at customized pH levels as a valuable strategy to address this. This study employed wet milling and spray drying techniques to create encapsulated NC for delivering the drug to the intestinal tract using the model drug ivermectin. Nanosuspensions (NS) were efficiently produced within two hours using NanoDisp®, with a particle size of 198.4 ± 0.6 nm and a low polydispersity index (PDI) of 0.184, ensuring uniformity. Stability tests over 100 days at 4°C and 25°C demonstrated practical viability, with no precipitation or significant changes observed. Cytotoxicity evaluations indicated less harm to Caco-2 cells compared to the pure drug. Furthermore, the solubility of the NC increased by 47-fold in water and 4.8-fold in simulated intestinal fluid compared to the pure active compound. Finally, dissolution tests showed less than 10% release in acidic conditions and significant improvement in simulated intestinal conditions, promising enhanced drug solubility and bioavailability. This addresses a long-standing pharmaceutical challenge in a cost-effective and scalable manner.
Cryopreservation of rat embryos at all developmental stages by small-volume vitrification procedure and rapid warming in cryotubes
Authors: Seki Shinsuke , Kawabe Toshiaki , Yamazaki Wataru , Matsumura Kazuaki , Oikawa Takanori , Obata Takahiro , Higashiya Misako , Yano Megumi , Eto Tomoo 
Published: September 2023

Abstract
Intracellular ice formation during cryopreservation is lethal to the cell, including during warming. Here, we examined the effect of sample volume and warming rate on the cryopreservation success of 1-cell rat embryos based on successful development into blastocysts in vitro and to term in vivo following embryo transfer. Embryos were equilibrated in 5% propylene glycol solution for 10 min, held for 40 s at 0°C in cryopreservation solution, and cooled by immersion in liquid nitrogen. When 1-cell embryos were cryopreserved in a volume of 30–100 uL at a cooling rate of 5,830–7,160°C/min and warmed at 35,480–49,400°C/min in 0.3 M sucrose at 50°C, 17.3%–28.8% developed into blastocysts, compared with 57.0% of untreated embryos. However, when 1-cell embryos were cryopreserved in a smaller volume of 15 ul at 7,950°C/min and warmed at 68,850°C/min, 58.8±10.6% developed into blastocysts and 50.0±7.4% developed to term, comparable to that of non-treated embryos (57.0±5.4% and 51.4±3.1%, respectively). Cryopreserved embryos at other developmental stages also showed high in vitro culture potential similar to that of the control. Using a conventional cryotube and a small-volume vitrification procedure with rapid warming, we achieved high levels of subsequent rat embryonic development at all developmental stages.
Sex-specific transgenerational effects imposed by ancestral exposure to neonicotinoid thiacloprid in murine thyroid gland
Authors: Lahmidi Mariam Diba , Noc Morgane Le , Dali Ouzna , Kernanec Pierre-Yves , Merret Pierre-Etienne , Jaulin Christian , Smagulova Fatima 
Published: September 2023

Abstract
Background
Neonicotinoids, a relatively new widely used class of insecticide is used in agriculture to control insect populations.
Objectives
We examined the capacity of ancestral exposure to the neonicotinoid thiacloprid (thia) to induce transgenerational effects on thyroid tissue.
Methods
Pregnant outbred Swiss female mice were exposed to thia at embryonic days E6.5 to E15.5 using 0, 0.6, and 6 mg/kg/day doses. Thyroid paraffin sections were prepared for morphology analysis. We apply ELISA method to measure T4 and TSH levels, RT-qPCR for gene expression analysis, ChIP-qPCR techniques for sperm histone H3K4me3 analysis, and immunofluorescence microscopy and western blots for protein detection.
Results
We observed an alteration in the morphology of thyroids in both males and females in the F3 generation. We observed an increase in T4 hormone in F1 females and a significant T4 level decrease in F3 males. T4 changes in F1 females were associated with a TSH increase. We found that the amount of Iodothyronine Deiodinase 1 (DIO1) (an enzyme converting T4 to T3) was decreased in both F1 and F3 generations in female thyroids. GNAS protein which is important for thyroid function has increased in female thyroids. Gene expression analysis showed that the expression of genes encoding thyroid gland development, chromatin, biosynthesis and transport factors were affected in the thyroid gland in both sexes in F1 and F3. The analysis of sperm histone H3K4me3 showed that H3K4me3 occupancy at the Dio1 locus has decreased while Thyroglobulin (Tg) and Matrix Metallopeptidase 2 (Mmp2) genes have increased H3K4me3 occupancy in the sperm of F3 mice.
Conclusion
Our data suggest that ancestral exposure to thiacloprid affects thyroid function not only in exposed but also in indirectly exposed F3 generation.
Sustainability of Organic Farming from a Global Perspective: A Critical Analysis of Soil Types and Fertility Status of Organically Managed vs. Chemicalized Vegetable Fields of South India
Authors: George Nirmal Philip , Ray Joseph George 
Published: September 2023

Abstract
Aims: Globally, organic farming is emerging as a promising alternative to chemicalized agriculture in overcoming agricultural challenges. However, experts often question its efficiency in maintaining soil fertility to sustain the global demand for agricultural production. South India, characterized by its rich agricultural heritage and diverse agroecosystems, stands as a unique test ground for analyzing the problems and prospects of sustainable organic farming. Therefore, the primary goal of the current studywas to assess the soil fertility status of organic vegetable fields concerning various agroclimatic zones, soil types, seasons, organic practices, and vegetable crops in South India as a model for global comparisons.
Method: The approach was an assessment of soil quality parameters such as soil pH, total organic carbon (TOC), soil available nitrogen (SAN), soil available phosphorus (SAP), and soil available potassium (SAK) as the basis of soil fertility status and to compare the soil quality at different levels.
Results: The organic fields didn't exhibit distinctiveness in soil parameters from that of chemicalized fields except for soil-specific variations in some fields. Soil fertility status was at par with chemicalized fields in the region. The region does not consistently monitor nutrient levels concerning soil type, climate, or seasons. Different kinds of organic practiceshad no significant influence on soil quality.
Conclusion: The study highlights the need for global standardization of procedures in organizing organic agriculture as a sustainable model of agricultural production.
Design and Develop Function for Research Based Application of Intelligent Internet-of-vehicles Model Based on Fog Computing
Authors: KHUDHUR Abduladheem Fadhil , Kurnaz Sefer 
Published: September 2023

Abstract
In this research, an advanced Large Energy-Aware Fog (LEAF) computing based technique was introduced that allows for the modeling of large-scale vehicular network scenarios for executing thousands of streaming applications on a distributed, heterogeneous infrastructure. Compute nodes can be interconnected with different types of wired or wireless networking protocols, and edge devices can be mobile and join or leave the topology during the simulation. This level of realism permits research on energy-conserving fog computing architectures leading to more informed decisions in the planning of future infrastructure. Furthermore, the proposed model enables online decision making based on power usage, which can be used to implement energy-aware task placement strategies or routing policies. These algorithms can make direct use of LEAF’s ability to trace the power usage of infrastructure back to the responsible applications in order to identify and mitigate potential inefficiencies. Moreover, different kinds of energy-saving mechanisms can be integrated into simulations. What further distinguishes LEAF from existing fog computing simulators is the combination of analytical and numerical modeling approaches. Instead of modeling network traffic in detail, all data flows, and power models are represented by parameterizable, mathematical equations. This method leads to results that are easy to analyze and ensures scalability to hundreds or thousands of devices and applications with percentage of distance between 1 to 1000 was covered up to 98.75% using the LEAF technique. The research collects findings of various papers on the energy usage of different compute and networking equipment, including a detailed derivation of WAN connection parameters, to provide the reader with examples on how to model and parameterize LEAF experiments. Furthermore, the evaluation results indicate that fog computing may indeed be able to conserve energy in the future, mainly by reducing WAN usage.
Combined treatment for a rare malignant glomus tumor of the esophagus with pulmonary and liver metastases: a case report and review of literature
Authors: Liu Yanan , Mao Jingjing , Shen Dongfeng , Jin Baoli , Feng Wuxue , Du Wenjing 
Published: September 2023

Abstract

Background:
Glomus tumors are typically benign soft tissue tumors that occur at the extremities; malignant and viscerally occurring cases are extremely rare.
Case Presentation:
We report a 49-year old male patient with a malignant esophageal glomus tumor that was complicated by lung and liver metastases. Genetic test results guided the patient's individualized treatment. Consequently, treatment with Anlotinib combined with Tislelizumab achieved significant clinical benefits.
Conclusion:
Our case report demonstrates that immunotherapy combined with anti-angiogenic therapy in patients with malignant esophageal glomus tumors can achieve significant efficacy and suggests the potential value of Next-Generation Sequencing(NGS) detection in guiding personalized treatments in patients with malignant esophageal glomus tumors.
Community bylaws concerning sexual and reproductive health and rights in Machinga district, Malawi: To what extent are they responsive to young people’s needs?
Authors: Kok Maryse , Munthali Alister , Mvula Peter , Chisiza Zindaba , Mat Marielle Le 
Published: September 2023

Abstract
Background
Community bylaws are commonly accepted mechanisms to influence behaviour change to achieve better health and development outcomes in sub-Saharan Africa. However, the uses, benefits, and potential downsides of community bylaws are largely unclear, especially regarding sexual and reproductive health and rights (SRHR) of young people. The objective of this study was to determine the extent to which community bylaws in Machinga district in southern Malawi are responsive to young people’s realities and SRHR needs.
Methods
In Phase 1 of this qualitative study, 35 community members were interviewed, including 14 young people (15–24 years), five parents, five traditional leaders, and eleven key informants. Based on findings from Phase 1, eleven members from local youth groups co-created a drama performance that covered issues concerning bylaws and young people’s SRHR (Phase 2). The drama was performed in the community, after which young women (18–24 years), young men (17–24 years), female and male parents discussed on what they saw in the drama, focusing on young people’s SRHR, in four focus group discussions (Phase 3). All transcripts were coded and thematically analysed and narratives were written on main themes.
Results
Three community SRHR bylaws, related to teenage pregnancy, child marriage, and sexual harassment and rape were identified and commonly accepted in the community. While these bylaws intend to reduce SRHR-related issues among young people, they are often not involved in bylaw formulation. The bylaws were associated with protection of girls, and a good reputation for boys, young men and traditional leaders. Bylaw enforcement faced problems, as fines were not in line with national laws, and wealthy offenders could avoid them through bribes. Effects of bylaws on teenage pregnancy rates seemed limited, while some positive effects on school readmission, prevention of child marriage, and reporting sexual harassment were reported.
Conclusions
The study revealed that community bylaws were accepted but not owned by young people, and had different effects on the rich versus the poor, and girls versus young men. Bylaws were associated with punishment in terms of money, which seemed to overpower their potential to promote rights and address social norms underlying SRHR issues of the youth.
Synthesis and characterization of nonmetal-doped TiO 2 nanoparticles for mineralization of rhodamine B dye
Authors: Karimi Maryam , Grayeli Alireza 
Published: September 2023

Abstract
A novel series of C-, N-, and F-doped TiO2 photocatalysts were fabricated using a simple sol-gel method, utilizing 4-(trifluoromethyl) nicotinic acid (TFNA) as a precursor for carbon, nitrogen, and fluorine doping. The resulting materials were characterized using different advanced techniques such as X-ray Diffraction (XRD), Diffuse Reflectance Spectroscopy (DRS), Raman spectroscopy, Fourier Transform Infrared Spectroscopy (FT-IR), Transmission Electron Microscopy (TEM), and Field Emission Scanning Electron Microscopy (FESEM). The synthesis approach involved the creation of nanoparticles with varying weights of TFNA, ranging from 0.3 wt% to 1.6 wt%, followed by calcination at ambient temperature. The resulting nanostructures were then tested for their efficiency in degrading rhodamine B (RhB) dye under ultraviolet (UV) light irradiation.The experimental findings revealed that the 1.6 wt% TFNA/TiO2 composite exhibited exceptional photocatalytic activity, with approximately 87.0% degradation efficiency towards RhB dye in aqueous solutions under UV light. This remarkable performance can be attributed to the increased lifetime of photogenerated electron-hole pairs and accelerated interfacial charge transfer rates.
An antibody ordered assembly functional BPE-ECL platform for aflatoxin B1 detection
Authors: Qiao Fanglin , Jiang Yanjun , Chen Yin , Xu Mingyao , Xiong Xiaohui , Liu Yuanjian 
Published: September 2023

Abstract
Due to the complex characteristics of food matrix, inaccurate results are likely to occur when using traditional methods to detect Aflatoxin B1 (AFB1). In this paper, a biosensor based on closed bipolar electrode (BPE) has been developed to detect highly toxic AFB1 in mycotoxins. The biosensor uses cathode of closed BPE as a functional sensing interface and anode as a signal collection interface. On the functional sensing interface, monoclonal antibody connecting AFB1 at the top of DNA tetrahedron structure. In the presence of horseradish peroxidase (HRP), hydrogen peroxide (H2O2) catalyzes the oxidation of 4-chloro-1-naphthol (4-CN) to produce insoluble precipitations (4-CD). AFB1 competes with HRP-AFB1 to bind monoclonal antibody, resulting in a decrease in the content of HRP involved in catalytic oxidation reactions and a synchronous reduction in precipitations produced. Due to the electron transfer is influence by precipitation capacity, the decrease in precipitations lead to an increase in the BPE anode luminescence signal. On the signal collection interface, AFB1 detection is achieved by measuring the ECL strength of the [Ru(bpy)3]2+/TPA system. Through the above methods, the target does not need to participate in the ECL reaction of the anode, avoiding the direct contact between the photoactive molecules and the complex food matrix. The analysis shows that the relative deviation from ELISA is between − 4.5 ~ 9.8%, indicating that there is no significant difference between the biosensor and ELISA. The BPE-ECL sensor exhibits high sensitivity and specificity in detecting AFB1, with a linear range of 0. 01–40 ng mL− 1 and a detection limit of 3 pg mL− 1. It can be further applied to the detection of different kinds of toxins and has broad application prospects.