bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of health expenditures and environmental degradation on health status—Disability-adjusted life years and infant mortality
Authors: Omri Anis , Kahouli Bassem , Kahia Montassar 
Published: March 2023

IntroductionHuman health and well-being are intimately related to environmental quality. In this respect, the present study contributes to the existing health economic literature by examining whether public and private health expenditures (PPHE) moderate the incidences of environmental degradation on the health status in Saudi Arabia, particularly disability-adjusted life years (DALYs) and infant mortality.MethodsUsing the fully modified ordinary least squares (FMOLS) method.Results and DiscussionThe empirical results revealed that (i) unconditional positive impacts of CO2 emissions on increasing DALYs and infant mortality; (ii) conditional negative impacts of public health expenditures on DALYs and infant mortality in all the estimated models, whereas global and private expenditure contribute only on reducing infant mortality; (iii) public health expenditure is more effective than private health expenditure in reducing infant mortality; (iv) the effects of the interactions between the indicators of both health expenditures and CO2 emissions on DALYs and infant mortality are negative and significant only for the specifications relating to public health expenditures, indicating that this later could be employed as a policy or conditional variable that moderates the adverse impacts of carbon emissions on the population’s health status. Generally, the study presents an overview of environmental health change’s effects and examine how these effects may be reduced through increasing health spending. The study provides recommendations for addressing health status, health expenditures, and carbon emissions, all of which are directly or indirectly linked to the study.
Network analysis of affect, emotion regulation, psychological capital, and resilience among Chinese males during the late stage of the COVID-19 pandemic
Authors: Guo Zhihua , Cui Yi , Yang Tianqi , Liu Xufeng , Lu Hongliang , Zhang Yinling , Zhu Xia 
Published: March 2023

BackgroundPrevious studies have confirmed that both affect and emotion regulation strategies are closely associated with psychological capital (PsyCap) and resilience. These factors are assumed to buffer the effect of the COVID-19 pandemic on mental health, especially among males. However, these interactions have not been closely examined to date. To fill this gap, this paper explores the dimension-level relationships of these psychological constructs among Chinese males during the late stage of the COVID-19 pandemic and identified critical bridge dimensions using network analysis.MethodsA total of 1,490 Chinese males aged 21–51 years completed self-report scales assessing emotion regulation strategies, affect, PsyCap, and psychological resilience. Two regularized partial correlation networks, namely the affect and emotion regulation-PsyCap network and the affect and emotion regulation-psychological resilience network, were then constructed to examine links between the dimensions of these constructs. The bridge expected influence (BEI) index was also calculated for each node to identify important bridge nodes.ResultsPositive affect, negative affect, cognitive reappraisal, and expressive suppression showed distinct and complex links to various dimensions of PsyCap or psychological resilience. In both networks, positive affect, cognitive reappraisal, and negative affect were identified as critical bridge nodes, with the first two having positive BEI values and the third having a negative value.ConclusionThe findings elucidate the specific role of the dimensions of emotion regulation or affect in relation to PsyCap and psychological resilience, which facilitates further understanding of the mechanisms underlying these interrelationships. These findings also provide implications for developing effective intervention strategies to increase PsyCap and psychological resilience.
The embryo mosaicism profile of next-generation sequencing PGT-A in different clinical conditions and their associations
Authors: Heiser Hadassa Campos , Cagnin Natalia Fagundes , de Souza Mariane Uehara , Ali Taccyanna Mikulski , Estrada Paula Regina Queiroz , de Souza Camila Cristina Wuaquim Dantas , Coprerski Bruno , Rubio Carmen , Riboldi Marcia 
Published: March 2023

IntroductionUniform chromosome abnormalities are commonly seen in early pregnancy loss, with analyses of the product of conception suggesting the presence of mosaic autosomal trisomy in ∼10% of cases. Although chromosomal mosaicism occurs in a minority of embryos, their relative commonality and uncertainty regarding associated transfer outcomes have created discussion at both the clinical and research levels, highlighting the need to understand the clinical conditions associated with the incidence of embryo mosaicism.MethodsWe took advantage of a preimplantation genetic testing for aneuploidy (PGT-A) database created from 2019 to 2022 in more than 160 in vitro fertilization (IVF) clinics in Brazil, the second-largest world market for IVF. We carried out descriptive statistical and associative analyses to assess the proportions of mosaicism associated with clinical conditions and reported incidence by chromosome, clinic origin, and biopsy operator.ResultsChromosomal analysis revealed that most mosaic aneuploidies occurred in the last three chromosomes, with 78.06% of cases having only one chromosome affected. Low mosaicism in trisomy represented the most ordinary form, followed by low mosaicism in monosomy. We identified associations between low (negatively-associated) and high mosaicism (positively-associated) and maternal age, indication (male factor and uterus/ovarian factor negatively associated with low and high mosaic, respectively), day of blastocyst development (day five has an overall better outcome), morphology grade (lower quality increased the chances of low and high mosaicism), origin (vitrified oocyte and embryo increased the rates of low and high mosaicism, respectively), and embryo sex (male embryos negatively associated with low mosaic).DiscussionWith these results, we hope to foster an improved understanding of the chromosomal mosaicism linked with distinct clinical conditions and their associations in Brazil.
Prevalence of extended-spectrum β-lactamase producing Enterobacterales in Africa's water-plant-food interface: A meta-analysis (2010–2022)
Authors: Richter Loandi , Du Plessis Erika M. , Duvenage Stacey , Korsten Lise 
Published: March 2023

BackgroundMultidrug-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacterales is regarded as a critical health issue, yet, surveillance in the water-plant-food interface remains low, especially in Africa.ObjectivesThe objective of the study was to elucidate the distribution and prevalence of antimicrobial resistance in clinically significant members of the Enterobacterales order isolated from the water-plant-food interface in Africa.MethodsA literature search was conducted using six online databases according to the PRISMA guidelines. All available published studies involving phenotypic and genotypic characterization of ESBL-producing Enterobacterales from water, fresh produce or soil in Africa were considered eligible. Identification and characterization methods used as well as a network analysis according to the isolation source and publication year were summarized. Analysis of Escherichia coli, Salmonella spp. and Klebsiella pneumoniae included the calculation of the multiple antibiotic resistance (MAR) index according to isolation sources and statistical analysis was performed using RStudio.ResultsOverall, 51 studies were included for further investigation. Twelve African countries were represented, with environmental AMR surveillance studies predominantly conducted in South Africa. In 76.47% of the studies, occurrence of antimicrobial resistant bacteria was investigated in irrigation water samples, while 50.98% of the studies included fresh produce samples. Analysis of bacterial phenotypic antimicrobial resistance profiles were reported in 94.12% of the studies, with the disk diffusion method predominantly used. When investigating the MAR indexes of the characterized Escherichia coli, Klebsiella pneumoniae and Salmonella spp., from different sources (water, fresh produce or soil), no significant differences were seen across the countries. The only genetic determinant identified using PCR detection in all the studies was the blaCTX − M resistance gene. Only four studies used whole genome sequence analysis for molecular isolate characterization.DiscussionGlobally, AMR surveillance programmes recognize ESBL- and carbapenemase-producing Enterobacterales as vectors of great importance in AMR gene dissemination. However, in low- and middle-income countries, such as those in Africa, challenges to implementing effective and sustainable AMR surveillance programmes remain. This review emphasizes the need for improved surveillance, standardized methods and documentation of resistance gene dissemination across the farm-to-fork continuum in Africa.
A meta-analysis of deltoid ligament on ankle joint fracture combining deltoid ligament injury
Authors: Yang XiaoLing , Zeng Jianshuang , Yang Wei , Dela Rosa Ronnell D , Jiang Zhixia 
Published: March 2023

PurposeAnkle fracture combined with deltoid ligament (DL) injury results in decreased stability of ankle mortise, reduced contact surface between tibial and talus, increased local stress, and increased postoperative complications. The purpose of this meta-analysis was to evaluate the postoperative effects of repairing ligaments in ankle fractures with DL rupture.MethodsAccording to the steps of the Cochrane systematic review, the related literatures from PubMed, Embase and the Cochrane Library Databases were retrieved as of September 1, 2021, and all relevant randomized controlled trials and retrospective studies were collected. The evaluation indicators include medial clear space (MCS), visual analogue scale (VAS), American Orthopedic Foot and Ankle Society (AOFAS), complications rate. Meta-analysis was conducted by RevMan® 5.3 provided by the Cochrane collaboration.ResultsA total of 388 patients (195 patients in the ligament repair group and 193 patients in the non-repair group) were included in 7 clinical trials. Meta-analysis data showed there were no statistically significant differences between the ligament repair group and non-repair group in final follow-up VAS, final AOFAS and postoperative MCS (P = 0.50, P = 0.04, P = 0.14, P = 0.14, respectively). Final follow-up MCS and complications rate in ligament repair group were smaller than those in the non-repair group and were statistically significant (P &lt; 0.00001, P = 0.006, respectively).ConclusionAlthough there was no difference in in final follow-up VAS, final follow-up AOFAS and postoperative MCS between experimental group and control group, It's statistically significant in final follow-up MCS and complications rate. Ligament repair could reduce the width of MCS, restore ankle stability, reduce the incidence of complications and lead to a better prognosis.
Comprehensive analysis of microRNA and metabolic profiles in bovine seminal plasma of different semen quality
Authors: Cao Wei , Sun Wenqiang , Chen Shiyi , Jia Xianbo , Wang Jie , Lai Songjia 
Published: March 2023

BackgroundSeminal plasma plays a pivotal role in modulating sperm viability and function. However, the underlying mechanisms have not been fully elucidated.MethodIn this study, the bull semen production records of core breeding farms and bull stations in the past 10 years were analyzed.ResultsWe found that the semen of 5-year-old bulls collected for the first time is of the best quality (p &lt; 0.05). Despite the bull semen collected under the above conditions, low-quality sperm is still obtained from part of bulls due to individual differences. Interestingly, seminal plasma from normal semen is capable of improving low-quality semen motility. To identify the potential key factors in seminal plasma, the differences in miRNA and metabolite profiles between normal and low-quality seminal plasma were analyzed. We found that 59 miRNAs were differently expressed, including 38 up-regulated and 21 down-regulated miRNAs. Three hundred and ninety-one and 327 significantly different metabolites were identified from the positive and negative ion models, respectively. These multiple miRNAs and metabolites collectively contribute to the motility of sperm, subsequently, affect semen quality.DiscussionTogether, these results not only revealed the critical factors of seminal plasma improving sperm quality but also provided potential miRNA- or metabolite-based biomarkers to identify the high semen quality.
Fabrication and Properties of the Multifunctional Rapid Wound Healing Panax notoginseng@Ag Electrospun Fiber Membrane
Authors: Gao Zhaoju , Liu Songlin , Li Shangfei , Shao Xinzhe , Zhang Pingping , Yao Qingqiang 
Published: March 2023

The Panax notoginseng@Ag core/shell electrospun fiber membrane was prepared by coaxial electrospinning combined with the UV reduction method (254 nm). The prepared Panax notoginseng@Ag core/shell nanofiber membrane has a three-dimensional structure, and its swelling ratio could reach as high as 199.87%. Traditional Chinese medicine Panax notoginseng can reduce inflammation, and the silver nanoparticles have antibacterial effects, which synergistically promote rapid wound healing. The developed Panax notoginseng@Ag core/shell nanofiber membrane can effectively inhibit the growth of the Gram-negative bacteria Escherichia coli and the Gram-positive bacteria Staphylococcus aureus. The wound healing experiments in Sprague Dawley mice showed that the wound residual area rate of the Panax notoginseng@Ag core/shell electrospun nanofiber membrane group was only 1.52% on day 9, and the wound of this group basically healed on day 12, while the wound residual area rate of the gauze treatment group (control group) was 16.3% and 10.80% on day 9 and day 12, respectively. The wound of the Panax notoginseng@Ag core/shell electrospun nanofiber membrane group healed faster, which contributed to the application of the nanofiber as Chinese medicine rapid wound healing dressings.
Small Ruminant Piroplasmosis: High Prevalence of Babesia aktasi n. sp. in Goats in Türkiye
Authors: Ulucesme Mehmet Can , Ozubek Sezayi , Karoglu Aleyna , Turk Zeliha Irem , Olmus Irem , Irehan Bunyamin , Aktas Munir 
Published: March 2023

Small ruminant piroplasmosis is the hemoparasitic infection of sheep and goats caused by Babesia and Theileria species responsible for clinical infections with high mortality outcomes. The disease is transmitted by ixodid ticks and prevalent in the tropical and subtropical regions of the world, including Türkiye. A prevalence survey, using molecular methods, is conducted in this study to determine the frequency of newly defined Babesia aktasi n. sp. and other tick-borne piroplasm species in small ruminants in Turkiye. A total of 640 blood samples from sheep (n = 137) and goats (n = 503) were analyzed by nested PCR-based reverse line blot (RLB) hybridization. The results show that 32.3% (207/640) of apparently healthy, small ruminants are infected with three Theileria and two Babesia species. Babesia aktasi n. sp. was the most prevalent species in goats, with 22.5% of samples being positive, followed by B. ovis (4%), T. ovis (2.8%), T. annulata (2.6%), and Theileria sp. (0.6%). None of the sheep samples were positive for Babesia aktasi n. sp.; however, 51.8% were infected with T. ovis. In conclusion, the findings reveal that B. aktasi n. sp. is highly prevalent in goats, but absent in sheep. In future studies, experimental infections will determine whether B. aktasi n. sp. is infectious to sheep, as well as its pathogenicity in small ruminants.
Structure of the space of GL4 (Z2)-coinvariants Z2 ⊗ GL4 (Z2) P H∗ (Z42,Z2) in some generic degrees and its application
Authors: Võ Phúc Đặng 
Published: March 2023

<p>Fix $k = \mathbb Z_2$ to be a field of characteristic 2, let $A$ denote the Steenrod algebra over $k.$ A problem of immense difficulty in algebraic topology is the determination of a minimal set of $A$-generators for the polynomial ring $P_q = k[x_1, \ldots, x_q] = H^{*}(k^{q}, k)$ on $q$ generators $x_1, \ldots, x_q$ with $|x_1|= |x_2| = \cdots = |x_q| = 1.$ By way of equivalence, one may choose to write an explicit basis for the cohit space $\pmb{Q}^{q} := k\otimes_{A} P_q$ in each non-negative degree $n.$ This subject, which has now a long history, is the content of the classical "hit problem" proposed in [Abstracts Papers Presented Am. Math. Soc. \textbf{833} (1987), 55-89]. Furthermore, it is closely related to the $q$-th transfer homomorphism $Tr_q^{A}$ constructed by William Singer in [Math. Z. \textbf{202} (1989), 493-523]. This map $Tr_q^{A}$ passes from the space of $G(q)$-coinvariant $k\otimes _{G(q)} P_A((P_q)_n^{*})$ of $\pmb{Q}^{q}$ to the $k$-cohomology group of the Steenrod algebra, ${\rm Ext}_{A}^{q, q+n}(k, k),$ wherein $G(q)$ stands for the general linear group of degree $q$ over the field $k,$ and $P_A((P_q)_n^{*})$ is the primitive part of $(P_q)^{*}_n$ under the action of $A.$ Particularly, the assertion that $Tr_q^{A}$ is always an injective map has been conjectured by Singer himself, but as of now, this remains an open problem for all $q\geq 4.$ Accordingly, the aim of the present study is to deal with the Singer conjecture for rank 4 in certain internal degrees. Specifically, by the usage of the techniques of the hit problem in four variables, we explicitly determine the structure of the coinvariant $k\otimes _{G(4)} P_A((P_4)_{n}^{*})$ in some generic degrees $n.$ Then, applying these results and a representation of $Tr_4^{A}$ via the lambda algebra, we state that Singer's conjecture is true for rank $q = 4$ in respective degrees $n.$ This has contributed to the final proof of Singer's conjecture in the rank 4 case.</p>
EEG-to-EEG: Scalp-to-Intracranial EEG Translation using a Combination of Variational Autoencoder and Generative Adversarial Networks
Authors: Abdi-Sargezeh Bahman 
Published: March 2023

<p>A generative adversarial network (GAN) enables mapping a data sample from one domain to another one. It has extensively been employed in image-to-image and text-toimage translation. We propose an EEG-to-EEG translation model based on a GAN structure in which a conditional GAN (cGAN) is combined with a variational autoencoder (VAE), named as VAE-cGAN. Scalp EEG (sEEG) is plagued by noise and suffers from low resolution. On the other hand, intracranial EEG (iEEG) recordings enjoy high resolution. Here, we consider the task of mapping the sEEG to iEEG to enhance the sEEG resolution. <br>
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ІНФОРМАЦІЙНО-АНАЛІТИЧНЕ ЗАБЕЗПЕЧЕННЯ ПРИЙНЯТТЯ УПРАВЛІНСЬКИХ РІШЕНЬ У СФЕРІ МАРКЕТИНГУ
Authors: Морохова Валентина  , Бойко Ольга  , Ковальчук Олег  
Published: March 2023

У статті розглянуто питання інформаційно-аналітичного забезпечення розробки, підтримки і реалізації маркетингових управлінських рішень. Встановлено, що нестабільність зовнішнього середовища функціонування підприємств вимагає від них прийняття нестандартних управлінських рішень, активізації маркетингових зусиль та індивідуалізації підходів до потреб цільових споживачів. За цих умов інформаційно-аналітичне забезпечення маркетингової діяльності виступає важливим інструментом адаптації підприємств до нестабільної кон’юнктури ринку. Узагальнено дослідження інформаційно-аналітичної складової маркетингової діяльності підприємств, за допомогою якої здійснюється спостереження, збирання та аналізування інформації про внутрішнє і зовнішнє середовище. Наголошено, що інформаційно-аналітичне забезпечення не повинно зводитися лише до акумулювання інформаційних ресурсів. Його метою повинно бути задоволення потреб суб’єктів господарювання в комплексі даних, цілеспрямований збір, обробка, аналіз і використання якісної інформації, здійснення оперативного та стратегічного моніторингу. Представлено і розглянуто спільні завдання та відмінності між маркетинговим аналізом і маркетинговими дослідженнями. Виділено дві основні групи маркетингових управлінських рішень: рішення у сфері стратегічного маркетингу та рішення у сфері тактичного маркетингу. Для успішного ведення маркетингової діяльності та прийняття ефективних управлінських рішень обґрунтовано необхідність використання сучасних інформаційних технологій та модернізації маркетингової інформаційної системи. Дослідженням доведено, що від якості інформаційно-аналітичного забезпечення маркетингової діяльності залежить ефективність маркетингових управлінських рішень. Недостатній рівень інформаційно-аналітичного забезпечення призводить до труднощів достовірної оцінки маркетингового потенціалу підприємств, що, в свою чергу, стає причиною прийняття необґрунтованих рішень у сфері маркетингу. Визначено шляхи удосконалення інформаційно-аналітичного забезпечення маркетингової складової системи управління підприємством.
Decoding reappraisal and suppression from neural circuits: A combined supervised and unsupervised machine learning approach
Authors: Ghomroudi Parisa Ahmadi , Scaltritti Michele , Grecucci Alessandro 
Published: March 2023

AbstractEmotion regulation is a core construct of mental health and deficits in emotion regulation abilities lead to psychological disorders. Reappraisal and suppression are two widely studied emotion regulation strategies but, possibly due to methodological limitations in previous studies, a consistent picture of the neural correlates related to the individual differences in their habitual use remains elusive. To address these issues, the present study applied a combination of unsupervised and supervised machine learning algorithms to the structural MRI scans of 128 individuals. First, unsupervised machine learning was used to separate the brain into naturally grouping grey matter circuits. Then, supervised machine learning was applied to predict individual differences in the use of different strategies of emotion regulation. Two predictive models, including structural brain features and psychological ones, were tested. Results showed that a temporo-parahippocampal-orbitofrontal network successfully predicted the individual differences in the use of reappraisal. Differently, insular and fronto-temporo-cerebellar networks successfully predicted suppression. In both predictive models, anxiety, the opposite strategy, and specific emotional intelligence factors played a role in predicting the use of reappraisal and suppression. This work provides new insights regarding the decoding of individual differences from structural features and other psychologically relevant variables while extending previous observations on the neural bases of emotion regulation strategies.
Measuring the quality of an e-learning course
Authors: Schreurs Jeanne , Lovasz Gabriella , Geder Mateja 
Published: March 2023

The EU Commission's learning action plan stresses the importance of ICT in education and quality assurance is part of the Bologna Declaration.
General approaches to quality and to measuring quality are ISO, TQM and EFQM and Kirkpatrick for education. 2 popular quality measuring models are SEVAQ and SEEQUEL which are both based on EFQM and Kirkpatrick.
In the project OLAREX a set of e-learning courses are developed to fulfill the project objectives: to enhance and modernize STEM curricula, foster students' creativity and motivation and develop professional e-didactic and technology competences and skills.
The following quality assurance methods and tools are used: external and internal evaluation, comparative assessments, learners evaluation using questionnaires, informal discussions, observations and networking.
A SEEQUEL revised model is developed by the external experts for the external evaluation. The model is described in the paper. Part of the evaluation report is presented. In this report strong and weak points are formulated and needed improvements of the e-learning courses are advised.