bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthosiphon aristatus Alleviates Skin Barrier through Cytokines Regulation in DNCB- induced Atopic Dermatitis BALB/C Mice Model
Authors: Handono Kusworini , Widasmara Dhelya , Susianti Hani , Pandaleke Thigita A 
Published: June 2023

Abstract
Background: to analysed the effect of Orthosiphon aristatus on repairing skin lesions by regulating cytokines such as IgE, IL4, IL22, PGE2, NO in DNCB-induced Atopic Dermatitis BALB/C Mice Model
Methods: used BALB/C Mice which were sensitized by DNCB for 21 days to developed atopic dermatitis model. Mice were administered oral Orthosiphon aristatus extract once daily (on last 14 days after 7 days of sensitization). The doses given were divided into 6 groups: 17.5 mg/kgbw, 35 mg/kgbw, 70 mg/kgbw, and 140 mg/kgbw. We analysed the levels of cytokines such as IgE, IL4, IL22, PGE2 obtained from the blood. Additionally, we also measured morphological skin lesion severity to confirmed the amelioration effect clinically.
Results: Administration of Orthosiphon aristatus extract reduced the skin lesion severity in all intervention groups. The clinical improvement was supported by decrease of IgE, IL4, IL22, and PGE2 in dose dependent manner.
Conclussion: Orthosiphon aristatus alleviates DNCB-induced Atopic Dermatitis BALB/C Mice Model clinically through downregulating of IgE, IL4, IL22, PGE2, NO levels.
Burnout among Army personnel: A Sri Lankan Experience
Authors: Pathirana Anushka Chamod , Nimesha Dilshi , Palliyaguruge Shehan Sajinda , Nazreen Zahra , Nishadi Upulika , Nishamini Prasadika , Ratnayake Himali Erandathie , Wickramasinghe Nuwan Darshana 
Published: June 2023

Abstract
Purpose
Given the relatively scarce evidence on mental health of the military personnel in the South Asian region, this study was conducted to assess the burnout status and factors associated with burnout among Army personnel in Sri Lanka.
Methods
A cross-sectional study was conducted in a selected Security Forces Headquarters in Sri Lanka using a self-administered questionnaire including the validated Sinhala version of the Copenhagen Burnout Inventory (CBI) to assess the burnout status. The 19-item CBI assessed three burnout subscales (personal, work-related, and client-related) using a five-point Likert scale. The summary statistics of the overall and subscale burnout scores were presented with mean (SD) and median (IQR). The statistically significant factors in the bivariate analysis (p < 0.05) were included in the multiple linear regression model to assess the independent associations of the factors with the overall burnout score.
Results
The response rate was 80.2% (n = 481). The majority were males (n = 467,97.5%). The mean (SD) age was 39.6 (4.8) years. The mean (SD) overall burnout score was 26.5 (13.3). In the bivariate analysis, service duration, job satisfaction, perceived satisfactory physical health and mental health revealed statistically significant results (p < 0.05). In the multiple linear regression, satisfactory level of perceived physical health (p = 0.046) and perceived mental health (p < 0.001) emerged as statistically significant independent predictors of overall burnout score.
Conclusion
The overall burnout score is relatively low among the Army personnel in the selected Security Forces Headquarters in Sri Lanka. Satisfactory levels of perceived physical health and mental health are significant independent predictors of burnout among Army personnel.
Clinical and Growth Correlates of Retinopathy of Prematurity in Preterm infants with Surgical Necrotizing Enterocolitis and intestinal Perforation
Authors: Riddick Robin , Meilstrup Asha , Ansari Md Abu Yusuf , Ware Jennifer , Zepponi David , Smith Andrea , Sawaya David , Mungan Nils , Garg Parvesh Mohan 
Published: June 2023

Abstract
Background: we sought to determine the clinical and growth parameters associated with retinopathy of prematurity (ROP) in infants with necrotizing enterocolitis (NEC) and spontaneous ileal perforation (SIP).
Methods: Retrospective cohort study comparing clinical information before and following NEC/SIP onset in neonates with and without severe ROP (Type 1 and 2).
Results: Those with severe ROP (32/109, 39.5%) had lower GA, BW, chorioamnionitis, later median onset of ROP diagnosis and received Penrose drain and had higher AKI, poor weight z scores, poor linear growth, longer duration of ventilation and higher FIo2 than those without ROP following NEC/SIP. The GA and diagnosis at later age remained significant for any ROP on multi regression modelling.
Conclusion: The surgical NEC/SIP infants with severe ROP were more likely to be younger, smaller, had AKI, had higher oxygen exposure and poor weight gain and linear growth than those without severe ROP.
New binary [72,36,12] self-dual codes from block circulant matrix
Authors: Yu Cong , Zhu Shixin , Wu Tingting 
Published: June 2023

Abstract
In this work, we use five different forms of generator matrix to construct self-dual codes over $\mathbb{F}_{8}$. Then we establish a mapping from $\mathbb{F}_{8}$ to $\mathbb{F}_2$} which enables us to map a linear code of length $n$ over $\mathbb{F}_{8}$ to a binary linear code of length $3n$ and preserves orthogonality. We employ the five forms of generator matrix to construct binary [72,36,12] self-dual codes and find 180 singly-even and 1 doubly-even codes with new parameter in their weight enumerators which are not known before. We summarize all of our discoveries in tables.
Black Women Undergraduates
Authors: Allen-Handy Ayana , Farinde-Wu Abiola , Graham DaVonna , Johnson Johnitha W. 
Published: June 2023

This disquisition is a phenomenological exploration of the lived experiences and identity construction of Black women undergraduates (BWU) at predominantly white institutions (PWIs). While recent literature has focused on Black women and graduate studies, this article’s explicit focus on BWU provides a needed perspective in the field, contributing to our growing understanding of the experiences of Black women at PWIs. The purpose of this study was to examine BWUs’ academic, social, and cultural lived experiences and the ways in which they constructed their identities within their respective PWIs environments. Situated upon a critical race feminist theoretical framework, data was collected through semi-structured interviews with seven participants. Findings reveal that BWU engage in various degrees of negotiating contexts, managing subjectivities, and (re)defining identities while navigating their respective campuses. This study supports extant and emerging literature centered on the experiences of BWU at PWIs, and extends the field’s understanding of the intersection between their lived experiences and their identity construction while attending PWIs, specifically. Our findings illuminate PWIs’ responsibility to transform systems and practices in order to foster positive academic and social experiences for BWU.
The Impactful Effect of E-Learning Study Method Towards Students Academic Achievements in General
Authors: Wairooy Irma Kartika , Reynard Alexander , Octodhia Muhammad Robih , Andanu Wan Mahardika , Suri Puti Andam , Syahputra Muhammad Edo 
Published: June 2023

This study aims to analyze the impact of the online learning or e-learning system on students' academic scores in general. This study uses previous research to review the infrastructure and factors of the E-Learning system in influencing students' academic scores. The research method of this research is using SLR (Systematic Literature Review). Research searches will be carried out on databases of journals that are known to the public, such as Springer, ResearchGate, Scopus, and others. Twenty-seven articles have been screened to fit the research criteria, collected, and reviewed. This study concludes that the E-Learning System gets honest feedback and is ignored, but indirectly has an impact on the actors in teaching and learning activities in the world of education. E-learning systems can provide solutions to problems at hand, but also create unfamiliar problems. The main factor in improving student learning experiences is student academic value.
Keyword - E-Learning, Online Platform, Education, Systematic Online Learning, Academic Achievement, non-Academic Achievement
Atividade física e saúde na educação física escolar: perspectivas de professores formadores
Authors: Nascimento Kessiane Fernandes , Torres Aline Lima , Ferreira Heraldo Simões 
Published: June 2023

Este estudo objetivou analisar a compreensão de professores do ensino superior acerca da relação teórico-metodológica entre atividade física e saúde nas aulas de Educação Física escolar. A pesquisa foi desenvolvida com sete professores de um curso de licenciatura em Educação Física de uma instituição privada que responderam um questionário composto por seis questões. O resultado mostrou ampla diversidade na compreensão da concepção de saúde, havendo entre eles tanto os que a associaram exclusivamente à ausência de doenças, como os que a entenderam como um direito social de perspectiva coletiva. Ao relacionar a saúde com a Educação Física escolar, percebeu-se que ainda existe a ideia de que esta disciplina é a principal responsável por abordar o tema, desconsiderando uma proposta coletiva e colaborativa entre os diferentes atores da escola. Com relação à atividade física no contexto da Educação Física escolar, cinco participantes posicionaram-se estabelecendo uma relação de causalidade com a saúde, e apenas dois a relativizaram a outros fatores. Ainda há um distanciamento significativo entre a compreensão de alguns professores e a proposta trazida pelo paradigma atual da Promoção da Saúde no que concerne à relação teórico-metodológica entre atividade física e saúde no contexto das aulas de Educação Física escolar.
Palavras-chave: Atividade Física. Saúde. Educação Física Escolar. Professores Formadores.
Uso de artículos de investigación en la construcción de pruebas en ecuaciones diferenciales
Authors: Landa Eddie Aparicio , Ávila Vales Eric José , Sosa Moguel Landy , García Almeida Gerardo 
Published: June 2023

El objetivo de esta investigación fue analizar cómo el uso artículos de investigación puede ser una estrategia pedagógica de aprendizaje activo por indagación que ayude a los estudiantes de matemáticas en la construcción de pruebas. El estudio se realizó bajo un paradigma cualitativo con enfoque interpretativo. Los datos se recopilaron durante un curso de modelación matemática de un programa de formación de matemáticos en una universidad pública del sureste de México. Nueve estudiantes participaron en este estudio y el profesor del curso. Los datos fueron analizados con base en la codificación de los razonamientos y estrategias seguidos por los estudiantes en su proceso de construcción de pruebas en relación con las cinco componentes que estructuran una competencia matemática y el ciclo de los cuatro modos de aprendizaje experiencial. El uso de artículos de investigación tuvo un rol esencial en el razonamiento adaptativo, la generación de argumentos e integración de conocimientos de los estudiantes durante la construcción de sus pruebas matemáticas sobre la positividad de las soluciones de un sistema de ecuaciones diferenciales e incluso, ayudó a superar dificultades tales como la comprensión de algunos teoremas implicados en las pruebas.
Trehalose and its Diverse Biological Potential
Authors: Sharma Eva , Shruti P.S. , Singh Shagun , Singh Tashvinder , Kaur Prabhsimran , Jodha Bhavana , Srivastava Yashi , Munshi Anjana , Singh Sandeep 
Published: June 2023

Abstract:Trehalose, a disaccharide molecule of natural origin, is known for its diverse biological applications, like in drug development, research application, natural scaffold, stem cell preservation, food, and various other industries. This review has discussed one such diverse molecule ‘trehalose aka mycose’, and its diverse biological applications with respect to therapeutics. Due to its inertness and higher stability at variable temperatures, it has been developed as a preservative to store stem cells, and later, it has been found to have anticancer properties. Trehalose has recently been associated with modulating cancer cell metabolism, diverse molecular processes, neuroprotective effect, and so on. This article describes the development of trehalose as a cryoprotectant and protein stabilizer as well as a dietary component and therapeutic agent against various diseases. The article discusses its role in diseases via modulation of autophagy, various anticancer pathways, metabolism, inflammation, aging and oxidative stress, cancer metastasis and apoptosis, thus highlighting its diverse biological potential.
High-Throughput Sequencing Reveals N6-Methyladenosine-modified
LncRNAs as Potential Biomarkers in Mice with Liver Fibrosis
Authors: Wu Furong , Zhang Shengyu , Fan Chang , Huang Shaopeng , Jiang Hui , Zhang Jiafu 
Published: June 2023

Background:
N6-methyladenosine (m6A) is the most frequent internal modification in eukaryotic RNA. Long noncoding RNAs (lncRNAs) are a new type of noncoding regulatory molecule with multiple cellular functions. Both are closely related to the occurrence and development of liver fibrosis (LF). However, the role of m6A-methylated lncRNAs in the progression of LF remains largely unknown.

Methods:
In this study, HE and Masson staining were used to observe pathological changes in the liver, m6A-modified RNA immunoprecipitation sequencing (m6A-seq) was performed to systematically evaluate the m6A modification level of lncRNAs in LF mice, meRIP-qPCR and RT-qPCR were used to detect the m6A methylation level and RNA expression level of the target lncRNAs.

Results:
A total of 415 m6A peaks were detected in 313 lncRNAs in liver fibrosis tissues. There were 98 significantly different m6A peaks in LF, which were located on 84 lncRNAs, of which 45.2% of the lncRNA length was between 200-400 bp. At the same time, the first three chromosomes of these methylated lncRNAs were chromosomes 7, 5 and 1. RNA sequencing identified 154 differentially expressed lncRNAs in LF. The joint analysis of m6A-seq and RNA-seq found that there were three lncRNAs with significant changes in m6A methylation and RNA expression levels: lncRNA H19, lncRNA Gm16023 and lncRNA Gm17586. Subsequently, the verification results showed that the m6A methylation levels of lncRNA H19 and lncRNA Gm17586 were significantly increased, while that of lncRNA Gm16023 was significantly decreased, and the RNA expression of three lncRNAs was significantly decreased. Through the establishment of a lncRNA-miRNA-mRNA regulatory network, the possible regulatory relationships of lncRNA H19, lncRNA Gm16023 and lncRNA Gm17586 in LF were revealed.

Conclusion:
This study revealed the unique m6A methylation pattern of lncRNAs in LF mice, suggesting that the m6A methylation modification of lncRNAs is related to the occurrence and development of LF.
Forgotten Topological and Wiener Indices of Prime Ideal Sum Graph of ℤn
Authors: Sözen Esra Öztürk , Eryaşar Elif , Abdioğlu Cihat 
Published: June 2023

Background:
Chemical graph theory is a sub-branch of mathematical chemistry, assuming each atom of a molecule is a vertex and each bond between atoms as an edge.

Objective:
Owing to this theory, it is possible to avoid the difficulties of chemical analysis because many of the chemical properties of molecules can be determined and analyzed via topological indices. Due to these parameters, it is possible to determine the physicochemical properties, biological activities, environmental behaviours and spectral properties of molecules. Nowadays, studies on the zero divisor graph of Z_n via topological indices is a trending field in spectral graph theory.

Methods:
For a commutative ring R with identity, the prime ideal sum graph of R is a graph whose vertices are nonzero proper ideals of R and two distinctvertices I and J are adjacent if and only if I+J is a prime ideal of R.

Results:
In this study the forgotten topological index and Wiener index of the prime ideal sum graph of Z_n are calculated for n=p^α,pq,p^2 q,p^2 q^2,pqr,p^3 q,p^2 qr,pqrs where p,q,r and s are distinct primes and a Sage math code is developed for designing graph and computing the indices.

Conclusion:
In the light of this study, it is possible to handle the other topological descriptors for computing and developing new algorithms for next studies and to study some spectrum and graph energies of certain finite rings with respect to PIS-graph easily.
Acute Pancreatitis Complicated by Thrombosis in the Right Brachiocephalic
Veins and Superior Vena Cava: A Case Report
Authors: Zhang Yan-li , Yang Bin , Yu Fei , Liu Yong , Si Guang-yan , He Qi-zhou 
Published: June 2023

Background::
Acute pancreatitis (AP) is one of the most common digestive emergencies, and vascular complication is one of the primary reasons for death, with
splanchnic venous thrombosis being the most common. Although extra-splanchnic venous thrombosis is rare, it carries the risk of life-threatening
secondary pulmonary embolism.

Case Presentation:
We have, herein, reported a case of AP complicated by rare brachiocephalic vein thrombosis and superior vena cava thrombosis. A 40 years old
woman was diagnosed with severe AP for abdominal pain 21 days ago. The patient received symptomatic treatment, including acid suppression,
enzyme suppression, lipid-lowering, fluid infusion, anti-infection, and continuous renal replacement therapy. The patient was discharged after
symptomatic relief. Recently, the patient was admitted again for middle-upper abdominal pain and discomfort. On admission, her blood platelet, DDimer,
fibrin degradation products (FDP), and triglyceride levels have been found to be increased; abdominal enhanced CT showed pancreatic
necrosis and an accumulation of peripancreatic necrosis and fluid, while chest enhanced CT suggested thrombosis in the right brachiocephalic vein
and superior vena cava. The patient, however, improved and was discharged after anticoagulation combined with insulin and trypsin inhibitors.

Conclusion::
In diagnosing and treating AP, dynamic monitoring of D-dimer levels is necessary for the timely detection of the development of thrombotic
complications.
Potential Mechanisms Underlying the Therapeutic Roles of Gancao
fuzi Decoction in Cold-dampness Obstruction Syndrome-type Knee
Osteoarthritis
Authors: Zhao Jinlong , Liang Guihong , Huang Hetao , Yang Weiyi , Pan Jianke , Luo Minghui , Zeng Lingfeng , Liu Jun 
Published: June 2023

Background:
The key active components and potential molecular mechanism of
Gancao Fuzi decoction (GFD) in the treatment of cold-dampness obstruction-type knee osteoarthritis
(KOA) remain unclear.

Objective:
To explore the mechanism of GFD in the treatment of cold-dampness obstruction
syndrome-type KOA by network pharmacology.

Methods:
The potential active components and targets of the four herbs in GFD (Fuzi, Guizhi,
Baizhu, and Gancao) were screened using the Traditional Chinese Medicine Systems Pharmacology
(TCMSP) database. The targets of KOA were obtained with the Comparative Toxicogenomics
Database (CTD), the GeneCards database, and the DisGeNET database, and the common
targets of the drugs and disease were ultimately obtained. Cytoscape (v.3.7.1) was used to draw
the active component-target network, and the Search Tool for the Retrieval of Interacting
Genes/Proteins (STRING) (v.11.0) database was used to construct the protein interaction network.
The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was used
for the Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG)
pathway enrichment analyses of the intersecting targets.

Results:
A total of 102 potential active components and 208 targets of GFD in the treatment of
cold-dampness obstruction syndrome-type KOA were screened. GFD treatment was found to be
closely related to many inflammatory signalling pathways in the treatment of KOA.

Conclusion:
The effect of GFD on cold-dampness obstruction syndrome-type KOA is mediated
by multicomponent, multitarget, and multichannel mechanisms, which provides the basis for further
experimental study of its pharmacodynamic material basis and mechanism.
Empowerment Provided by Health Education and its Impact on Self-care:
Report of a Pharmaceutical Intervention
Authors: de Oliveira Alan Maicon , Romeiro Barbara Falaschi , Rodrigues João Paulo Vilela , Varallo Fabiana Rossi , Leira Pereira Leonardo Regis 
Published: June 2023

Aims:
Older people, due to the development of multiple morbidities and in a situation of
polypharmacy, become fragile in addition to their own physical and organic aging. For different reasons regarding the treatment, the health care provided, or the physical and mental condition of older
people, problems of adherence to pharmacotherapy are present. Pharmaceutical care is an important
practice to ensure rational pharmacotherapy for this population. The present study aims to describe the
report of pharmacotherapeutic follow-up to a hospitalized older individual with multimorbidity and
use of polypharmacy and to highlight an intervention aimed at adherence to pharmacotherapy.

Case presentation:
This is the planning of a strategy, aimed at promoting health education, which was
carried out during the hospital stay of an older person who was included in the institution's pharmaceutical care services. In addition, at hospital discharge, in order to ensure greater benefits, a bag was
made for the correct storage of medicines and a descriptive didactic list on how to use them. In this
way, improvements were achieved in the transition of care for this patient.

Conclusion:
The importance of developing techniques that promote adherence to pharmacotherapy,
especially for fragile populations, such as older people with multiple diseases, and using polypharmacy is suggested. Individualized educational interventions are instructive measures that can contribute
to people's autonomy in their self-care.
Vulnerabilidad costera y cambio climático: propuesta metodológica de prospectiva participativa basada en las Trayectorias Socioeconómicas Compartidas (SSP)
Authors: Nájera González Areli , Marceleño Flores Susana , Chávez-Dagostino Rosa María , Nájera González Oyolsi , Carrillo González Fátima Maciel 
Published: June 2023

Objetivo: diseñar un proceso prospectivo participativo con base en los escenarios SSP para estimar la vulnerabilidad futura al cambio climático de un territorio costero. Tomando como caso de estudio San Blas, Nayarit; una zona rural con actividad turística en el Pacífico mexicano.
Diseño metodológico: con base en los principios de prospectiva territorial, el método consistió en dos secciones. La elaboración de un diagnostico prospectivo en donde se presenta un modelo para analizar la vulnerabilidad territorial histórica, actual y su tendencia. Y el diseño de un proceso prospectivo participativo, que fue compuesto por la selección de actores clave, la delimitación espacio-temporal, elección de escenarios y dinámica del taller prospectivo.
Resultados: de acuerdo con el diagnostico; la vulnerabilidad de la zona aumentó de nivel bajo a nivel medio entre 2000 y 2019, y se proyecta que incremente a nivel medio-alto en 2038. Las zonas más vulnerables resultaron las cubiertas por ecosistemas estuarinos y manglares. De la propuesta metodológica de prospectiva participativa se presenta una guía en formato cuadernillo de trabajo, en donde se describe a detalle la dinámica para conducir el taller abordando tres escenarios SSP.
Limitaciones de la investigación: la principal limitante fue la escasez de información a nivel local para analizar cada uno de los componentes de vulnerabilidad en el diagnóstico prospectivo. La aplicación de la propuesta metodológica del taller prospectivo y sus resultados serán motivo de análisis en una segunda fase de la investigación.
Hallazgos: la actividad turística orientado al ecoturismo puede ser el vehículo que conduzca la propuesta y aplicación de estrategias de adaptación para reducir la vulnerabilidad de la zona al cambio climático.