bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudoaneurysm after aortopulmonary window repair and bilateral lung transplantation for eisenmenger syndrome: a case report
Authors: Nagashima Toshiaki , Taira Masaki , Hasegawa Moyu , Kugo Yosuke , Watanabe Takuji , Yoshioka Daisuke , Shimamura Kazuo , Ueno Takayoshi , Miyagawa Shigeru 
Published: July 2023

Abstract
Background
Aortopulmonary window (APW) is a rare congenital cardiac anomaly characterized by communication between the main pulmonary artery and ascending aorta. There are various surgical techniques, and the short- and long-term results are excellent if the surgical repair is performed early in life. To our knowledge, there have been no reports of pseudoaneurysm after APW repair. Herein, we present a case of a 30-year-old woman with an ascending aortic pseudoaneurysm found at the site of APW repair nine months after the APW repair and bilateral lung transplantation.

Case presentations
A 30-year-old woman presented with APW and Eisenmenger syndrome. The patient underwent APW repair and bilateral lung transplantation. We transected the communication between the aorta and pulmonary artery and closed the aortic side directly with strips of felts. Nine months after the surgery, the patient complained of chest pain. Cardiac computed tomography revealed an ascending aortic pseudoaneurysm at the anastomotic site. Emergent graft replacement of the ascending aorta was performed and the postoperative course was uneventful.

Conclusions
We have presented a case of a pseudoaneurysm at the anastomotic site after APW repair and bilateral lung transplantation. The choice of surgical technique should be based on the patient’s background requiring lung transplantation, and in these cases close postoperative follow-up is required.
Landscape of PCOS co-expression gene and its role in predicting prognosis and assisting immunotherapy in endometrial cancer
Authors: Zhang Yun , Hu Yifang , Yu Jian , Xie Xiaoyan , Jiang Feng , Wu Chuyan 
Published: July 2023

Abstract
Background
Endometrial carcinoma (EC) is the sixth most frequent malignancy in women and is often linked to high estrogen exposure. Polycystic ovarian syndrome (PCOS) is a known risk factor for EC, but the underlying mechanisms remain unclear.

Methods
We investigated shared gene signals and potential biological pathways to identify effective therapy options for PCOS- and EC-related malignancies. Weighted gene expression network analysis (WGCNA) was used to identify genes associated with PCOS and EC using gene expression data from the Gene Expression Omnibus (GEO) and Cancer Genome Atlas (TCGA) datasets. Enrichment analysis using Cluego software revealed that the steroid hormone biosynthetic process was a critical feature in both PCOS and EC. A predictive signature encompassing genes involved in steroid hormone production was developed using multivariate and least absolute shrinkage and selection operator (LASSO) regression analysis to predict the prognosis of EC. Then, we conducted further experimental verification.

Results
Patients in the TCGA cohort with high predictive scores had poorer outcomes than those with low scores. We also investigated the relationship between tumor microenvironment (TME) features and predictive risk rating and found that patients with low-risk scores had higher levels of inflammatory and inhibitory immune cells. Also, we found that immunotherapy against anti-CTLA4 and anti-PD-1/PD-L1 was successful in treating individuals with low risk. Low-risk individuals were more responsive to crizotinib therapy, according to further research performed using the “pRRophetic” R package. We further confirmed that IGF2 expression was associated with tumor cell migration, proliferation, and invasion in EC cells.

Conclutions
By uncovering the pathways and genes linking PCOS and EC, our findings may provide new therapeutic strategies for patients with PCOS-related EC.
Renal interferon-inducible protein 16 expression is associated with disease activity and prognosis in lupus nephritis
Authors: Wang Xueyao , Fu Shaojie , Yu Jinyu , Ma Fuzhe , Zhang Lihong , Wang Jiahui , Wang Luyu , Tan Yue , Yi Huanfa , Wu Hao , Xu Zhonggao 
Published: July 2023

AbstractBackgroundLupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). However, the current management of LN remains unsatisfactory due to sneaky symptoms during early stages and lack of reliable predictors of disease progression.MethodsBioinformatics and machine learning algorithms were initially used to explore the potential biomarkers for LN development. Identified biomarker expression was evaluated by immunohistochemistry (IHC) and multiplex immunofluorescence (IF) in 104 LN patients, 12 diabetic kidney disease (DKD) patients, 12 minimal change disease (MCD) patients, 12 IgA nephropathy (IgAN) patients and 14 normal controls (NC). The association of biomarker expression with clinicopathologic indices and prognosis was analyzed. Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) were utilized to explore potential mechanisms.ResultsInterferon-inducible protein 16 (IFI16) was identified as a potential biomarker for LN. IFI16 was highly expressed in the kidneys of LN patients compared to those with MCD, DKD, IgAN or NC. IFI16 co-localized with certain renal and inflammatory cells. Glomerular IFI16 expression was correlated with pathological activity indices of LN, while tubulointerstitial IFI16 expression was correlated with pathological chronicity indices. Renal IFI16 expression was positively associated with systemic lupus erythematosus disease activity index (SLEDAI) and serum creatinine while negatively related to baseline eGFR and serum complement C3. Additionally, higher IFI16 expression was closely related to poorer prognosis of LN patients. GSEA and GSVA suggested that IFI16 expression was involved in adaptive immune-related processes of LN.ConclusionRenal IFI16 expression is a potential biomarker for disease activity and clinical prognosis in LN patients. Renal IFI16 levels may be used to shed light on predicting the renal response and develop precise therapy for LN.
The role of Huidouba in regulating skeletal muscle metabolic disorders in prediabetic mice through AMPK/PGC-1α/PPARα pathway
Authors: Tian Yu , Shi Dongxu , Liao Haiying , Lu Binan , Pang Zongran 
Published: July 2023

AbstractPrediabetes is a transitional state between normal blood glucose levels and diabetes, but it is also a reversible process. At the same time, as one of the most important tissues in the human body, the metabolic disorder of skeletal muscle is closely related to prediabetes. Huidouba (HDB) is a clinically proven traditional Chinese medicine with significant effects in regulating disorders of glucose and lipid metabolism. Our study aimed to investigate the efficacy and mechanism of HDB in prediabetic model mice from the perspective of skeletal muscle. C57BL/6J mice (6 weeks old) were fed a high-fat diet (HFD) for 12 weeks to replicate the prediabetic model. Three concentrations of HDB were treated with metformin as a positive control. After administration, fasting blood glucose was measured as an indicator of glucose metabolism, as well as lipid metabolism indicators such as total triglyceride (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), free fatty acid (FFA), and lactate dehydrogenase (LDH). Muscle fat accumulation and glycogen accumulation were observed. The protein expression levels of p-AMPK, AMPK, PGC-1α, PPAR-α, and GLUT-4 were detected. After HDB treatment, fasting blood glucose was significantly improved, and TG, LDL-C, FFA, and LDH in serum and lipid accumulation in muscle tissue were significantly reduced. In addition, HDB significantly upregulated the expression levels of p-AMPK/AMPK, PGC-1α, PPAR-α, and GLUT-4 in muscle tissue. In conclusion, HDB can alleviate the symptoms of prediabetic model mice by promoting the AMPK/PGC-1α/PPARα pathway and upregulating the expression of GLUT-4 protein.
Multi-task deep cross-attention networks for far-field speaker verification and keyword spotting
Authors: Liang Xingwei , Zhang Zehua , Xu Ruifeng 
Published: July 2023

AbstractPersonalized voice triggering is a key technology in voice assistants and serves as the first step for users to activate the voice assistant. Personalized voice triggering involves keyword spotting (KWS) and speaker verification (SV). Conventional approaches to this task include developing KWS and SV systems separately. This paper proposes a single system called the multi-task deep cross-attention network (MTCANet) that simultaneously performs KWS and SV, while effectively utilizing information relevant to both tasks. The proposed framework integrates a KWS sub-network and an SV sub-network to enhance performance in challenging conditions such as noisy environments, short-duration speech, and model generalization. At the core of MTCANet are three modules: a novel deep cross-attention (DCA) module to integrate KWS and SV tasks, a multi-layer stacked shared encoder (SE) to reduce the impact of noise on the recognition rate, and soft attention (SA) modules to allow the model to focus on pertinent information in the middle layer while preventing gradient vanishing. Our proposed model demonstrates outstanding performance in the well-off test set, improving by 0.2%, 0.023, and 2.28% over the well-known SV model emphasized channel attention, propagation, and aggregation in time delay neural network (ECAPA-TDNN) and the advanced KWS model Convmixer in terms of equal error rate (EER), minimum detection cost function (minDCF), and accuracy (Acc), respectively.
Interventions targeting the mental health and wellbeing of care-experienced children and young people in higher-income countries: Evidence map and systematic review
Authors: Evans Rhiannon , MacDonald Sarah , Trubey Rob , Noyes Jane , Robling Michael , Willis Simone , Boffey Maria , Wooders Charlotte , Vinnicombe Soo , Melendez-Torres G. J. 
Published: July 2023

AbstractBackgroundThe mental health and wellbeing of care-experienced children and young people (i.e. foster care, kinship care, residential care) is poorer than non-care-experienced populations. The Care-experienced cHildren and young people’s Interventions to improve Mental health and wEll-being outcomes Systematic review (CHIMES) aimed to synthesise the international evidence base for interventions targeting subjective wellbeing, mental health and suicide amongst care-experienced young people aged ≤ 25 years.MethodsFor the first phase of the review, we constructed an evidence map identifying key clusters and gaps in interventions and evaluations. Studies were identified through 16 electronic databases and 22 health and social care websites, in addition to expert recommendations, citation tracking and screening of relevant systematic reviews. We charted interventions and evaluations with a summary narrative, tables and infographics.ResultsIn total, 64 interventions with 124 associated study reports were eligible. The majority of study reports were from the USA (n = 77). Interventions primarily targeted children and young people’s skills and competencies (n = 9 interventions), the parental functioning and practices of carers (n = 26), or a combination of the two (n = 15). While theoretically under-specified, interventions were largely informed by theories of Attachment, Positive Youth Development, and Social Learning Theory. Current evaluations prioritised outcomes (n = 86) and processes (n = 50), with a paucity of study reports including theoretical descriptions (n = 24) or economic evaluations (n = 1). Interventions most frequently targeted outcomes related to mental, behavioural or neurodevelopmental disorders, notably total social, emotional and behavioural problems (n = 48 interventions) and externalising problem behaviours (n = 26). There were a limited number of interventions targeting subjective wellbeing or suicide-related outcomes.ConclusionsFuture intervention development might focus on structural-level intervention theories and components, and target outcomes related to subjective wellbeing and suicide. In accordance with current methodological guidance for intervention development and evaluation, research needs to integrate theoretical, outcome, process and economic evaluation in order to strengthen the evidence base.Systematic review registrationPROSPERO CRD42020177478.
Effective inclusion practices for neurodiverse children and adolescents in informal STEM learning: a systematic review protocol
Authors: Jenson Ronda J. , Lee Michele S , Day Arden D. , Hughes Amy E. , Maroushek Emma E. , Roberts Kelly D. 
Published: July 2023

Abstract
Background
Informal learning experiences in science, technology, engineering, and math (STEM) can enhance STEM learning that occurs in formal educational settings and curricula as well as generate enthusiasm for considering STEM careers. The aim of this systematic review is to focus on the experiences of neurodiverse students in informal STEM learning. Neurodiversity is a subgroup of neurodevelopmental conditions, such as autism, attention deficit disorder, dyslexia, dyspraxia, and other neurological conditions. The neurodiversity movement regards these conditions as natural forms of human variation, as opposed to dysfunction, and recognizes that neurodiverse individuals possess many strengths relevant to STEM fields.

Methods
The authors will systematically search electronic databases for relevant research and evaluation articles addressing informal STEM learning for K-12 children and youth with neurodiverse conditions. Seven databases and content-relevant websites (e.g., informalscience.org) will be searched using a predetermined search strategy and retrieved articles will be screened by two members of the research team. Data synthesis will include meta-synthesis techniques, depending on the designs of the studies.

Discussion
The synthesis of the findings resulting from various research and evaluation designs, across the K-12 age span, and across various informal STEM learning contexts, will lead to depth and breadth of understanding of ways to improve informal STEM learning programs for neurodiverse children and youth. The identification of informal STEM learning program components and contexts shown to yield positive results will provide specific recommendations for improving inclusiveness, accessibility, and STEM learning for neurodiverse children and youth.

Trial registration
The current study has been registered in PROSPERO. Registration number: CRD42021278618.
Physiotherapy management of children with cerebral palsy in low- and middle-income countries: a scoping review protocol
Authors: Duma Noxolo E. , Hlongwa Mbuzeleni , Benjamin-Damons Natalie , Hlongwana Khumbulani W. 
Published: July 2023

Abstract
Introduction
Cerebral Palsy (CP) is the most common childhood physical disability worldwide. Approximately 1.5 to 4 children per live births live with CP, globally. There have been no specific treatments that can reverse the brain damage responsible for the complex clinical dysfunctions of CP. There are, however, several interventions that are currently being used by physiotherapists, most of which are deemed to be ineffective and unnecessary. We will conduct a scoping review aimed at mapping evidence on the physiotherapy management of children living with CP in low- and middle-income countries (LMICs).

Methods
The scoping review will be guided by the Arksey and O’Malley and Levac et al. frameworks. The databases that will be used to search for literature include PubMed, MEDLINE, CINAHL, EBSCOhost, Web of Science, and ProQuest One Academic and Scopus. Gray literature articles will also be included in this review, provided they meet our inclusion criteria. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis: Extension for Scoping Reviews (PRIMSA-ScR) guideline will be used to report the results of the scoping review. The screened results will be reported using the PRISMA flow diagram guidelines, and the results will be charted using an electronic data charting form and analyzed using thematic analysis.

Discussion
Understanding how physiotherapists manage children with CP in LMICs is essential for the development of internationally sound, yet locally relevant, intervention strategy for physiotherapists. It is anticipated that the results of the scoping review will inform the thinking geared towards the development of a contextualised evidence-based framework for physiotherapists to effectively manage CP in children.

Systematic review registration
Open Science Framework. https://doi.org/10.17605/OSF.IO/VTJ84
Association of statin use and increase in lipoprotein(a): a real-world database research
Authors: Feng Tienan , Li Yao , Xue Xiongfeng , Yang Wei , Li Qiang , Huang Yushi , Zhu Tengteng , Wang Jue , Xu Limin , Li Xianchen , Gao Jing , Sun Shiming , Zhu Bin , Zhang ShuYu , Cao Beibei , Xuan Jianwei , Zhao Zhigang , Qian Biyun 
Published: July 2023

Abstract
Background
There is an increased concern that statins may have an unintended effect of elevated lipoprotein(a) [Lp(a)]. We conducted a large sample real-world study to test the association.

Methods
This retrospective cohort study was conducted using data from an integrated SuValue database, which includes 221 hospitals across China covering more than 200,000 of population with longitudinal follow-up to 10 years. Propensity score matching was applied to identify two comparable cohorts with statin users and non-statin users. Detailed follow-up information such as Lp(a) levels were extracted. The hazard ratio was calculated on Lp(a) changes based on the statin usage cohorts. Detailed subgroup and different characteristic cohorts’ analyses were also conducted.

Results
After baseline propensity score matching, a total of 42,166 patients were included in a 1:1 matched ratio between statin users and non-statin users. In the case of no difference in low density lipoprotein (LDL-C), Lp(a) was increased significantly with the use of statins (adjusted HR 1.47; 95% confidence interval [CI] 1.43–1.50). Lp(a) increase was observed in various subgroup analyses and different cohorts. The dose intensity of statin was positively associated with the evaluated Lp(a) level.

Conclusion
The use of statins was associated with an increased risk of Lp(a) elevation compared with non-statin use counterparts. The clinical relevance of these increases needs to be addressed in surrogate marker trials and/or large, cardiovascular outcomes trials.
BUN level is associated with cancer prevalence
Authors: Wang Cai , Sun Hao , Liu Jin 
Published: July 2023

AbstractBlood urea nitrogen (BUN) was an important biomarker for the development and prognosis of many diseases. Numerous studies had demonstrated that BUN had a strong relationship with long-term mortality, survival and the prevalence of some diseases. The diagnosis and treatment, prognosis and long-term survival rate of cancer were the focus of clinical research at present. However, the relationship between BUN level and cancer prevalence was not clear. To investigate the relationship between BUN level and cancer prevalence, we performed a statistical analysis of population data from the National Health and Nutrition Examination Survey (NHANES) database. The results of the study showed that BUN level were positively correlated with cancer prevalence, and the correlation was more pronounced in breast cancer.
Does loop length change after anterior cruciate ligament reconstruction with adjustable loop cortical suspension device?: Observation of the hamstring graft completely filling the femoral tunnel
Authors: Hyodo Kojiro , Kanamori Akihiro , Watanabe Ryunosuke , Ainoya Takeshi , Kikuchi Naoya , Arai Norihito , Yamazaki Masashi 
Published: July 2023

AbstractPurposeThe adjustable loop cortical suspension device (ALD) is a useful femoral fixation device in anterior cruciate ligament (ACL) reconstructions, but the possibility of loosening has been suggested. The purpose of this study was to evaluate the elongation of an adjustable loop and the position of the hamstring graft inside the femoral socket.MethodsThe subjects were 33 patients who underwent ACL reconstruction with a hamstring tendon. The graft was fixed using ALD and completely filled the femoral socket. Magnetic resonance images were taken one week and one year after the operation. The loop length, femoral socket length, and graft length inside the socket were measured and statistically compared with the clinical outcomes.ResultsThe loop length one week after surgery was 18.9 ± 4.4 mm, and 1 year after surgery was 19.9 ± 4.5 mm (P < 0.001). The gap between the top of the graft and femoral socket was 0.9 ± 1.8 mm one week after surgery and 1.3 ± 1.7 mm one year after surgery (P = 0.259). At one week post‐operation, a gap was found in nine patients (27.3%). The loop length and gap did not strongly correlate with clinical findings.ConclusionACL reconstruction using ALD showed a gap between the graft and femoral socket at the one week post‐operation mark in 27.3% of participants. One year after the surgery, there were cases where the gap increased and/or decreased, but the elongation of the loop was 1 mm on average. Our findings suggest that ALD is clinically safe to use; however, has the possibility of initial loop elongation and non‐uniform changes.Level of evidenceIV.
Teaching and learning the four English skills before and during the COVID-19 era: perceptions of EFL faculty and students in Saudi higher education
Authors: Alhaider Siham Mousa 
Published: July 2023

AbstractAt the peak of the COVID-19 pandemic in 2020, synchronous online learning replaced physical classes worldwide. However, sustaining the quality of education during this transition was a challenge. Specifically, teaching and learning the four English skills (listening, speaking, reading and writing) among English-as-a-foreign-language (EFL) learners in contexts such as Saudi Arabia required greater adjustments to meet learners’ demands during the pandemic. Within this context, this study explored how online teaching and learning helped develop the four English skills among Saudi EFL students. A survey was conducted among EFL faculty and learners in a Saudi Arabian higher-learning institution regarding the diverse aspects of language skills development before and during the pandemic. Data were analyzed using descriptive and inferential statistics. The results showed that e-learning was most beneficial for writing and least beneficial for speaking and that writing was most nurtured and adopted in almost all schoolwork, while speaking was neglected during online courses. Indeed, instructors must be prepared for an effective online learning experience in the future. This study aims to strengthen the field of EFL teaching and learning in Saudi Arabia and related contexts by describing learners’ perceptions of their experiences before and during the pandemic.
Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer
Authors: Wang Huizeng , Liu Bingchun , Chen Hong , Xu Peixin , Xue Huiting , Yuan Jianlong 
Published: July 2023

AbstractBenzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and carcinogenesis in human respiratory system, digestive system, reproductive system, etc. Moreover, BaP triggered genome-wide epigenetic alterations by methylation, which might cause disturbances in regulation of gene expression, and thereby induced cancer. It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression. Here we summarized the changes in DNA methylation in BaP exposure, and revealed the methylation of DNA plays a role in cancer development.
Graphical Abstract