bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perception, force, and content
Authors: Gregory Dominic 
Published: September 2023

AbstractPerceptual experiences have presentational phenomenology: we seem to encounter real situations in the course of visual experiences, for instance. The current paper articulates and defends the claim that the contents of at least some perceptual experiences are inherently presentational. On this view, perceptual contents are not always forceless in the way that, say, the propositional content that 2 + 2 = 4 is generally taken to be, as a content that may be asserted or denied or merely supposed; rather, there are perceptual contents such that any mental state or episode which has the relevant content must be one in which things seem to the given subject to be a certain way. Intuitive motivation for the view is presented and an explanatory line of argument in support of it is developed: it is argued that the recognition of inherently presentational perceptual contents allows us to explain certain representational limitations to which ordinary visualizations and other forms of perceptual mental imagery are subject. Some potential objections to the position are explored, leading to further elaboration of it.
Development of actinic lentigines due to multiple sub‐erythemal exposure to UVA1 radiation in Asian skin
Authors: Morita Akimichi , Seité Sophie , Le Dantec Guenaelle , Kerob Delphine 
Published: September 2023

AbstractThe appearance of actinic lentigines mainly found on face, back of the hands, upper back and décolleté is associated with chronic sun exposure. However, there is no study looking at the role of long UVA specifically in the development of actinic lentigines. This study was conducted in 20 Japanese adult women exposed on the upper back area three times per week for 6 weeks to incremental sub‐erythemal UVA1 doses (5 J/cm2 at weeks 1 and 2, 10 J/cm2 at weeks 3 and 4 and 15 J/cm2 at weeks 5 and 6). Clinical assessment, performed on day 0 (before any exposure), and on days 14, 28 and 42, included the evaluation of skin pigmentation (pigmented spots), chromametry of the pigmented skin lesions and measurement of dyschromy. The number of pigmented spots and uniformity of the skin's pigmentation were clearly increased in comparison with baseline, statistical significance of the difference (p < 0.05) being reached at D 28 and D 42 in both cases. In conclusion, repeated sub‐erythemal UVA1 exposure induces the development of actinic lentigines. Thus, a suitable protection including long UVA coverage is also needed to prevent from the damages induced by low, sub‐erythemal doses of UV exposure.
Relationship risk factors for intimate partner violence among sexual and gender minorities: A multilevel analysis
Authors: Sarno Elissa L. , Swann Gregory , Newcomb Michael E. , Whitton Sarah W. 
Published: September 2023

AbstractIntimate partner violence (IPV) is alarmingly prevalent among sexual and gender minority youth assigned female at birth (SGM‐AFAB), making it important to identify risk factors that can be targeted in prevention efforts for this population. Although several relationship‐level risk factors for IPV have been identified in different‐sex couples, research on SGM‐AFAB is sparse and predominantly cross‐sectional. The present study used seven waves of data from a longitudinal cohort study of SGM‐AFAB youth (n = 463) to explore relationship factors (relationship quality, destructive conflict, and self‐ and partner‐jealousy) as risk factors for perpetration and victimization of three types of IPV (physical, psychological, and coercive control). At each wave, participants reported on relationship factors and IPV for up to three romantic partners in the past 6 months. Multilevel models tested for associations between the relationship factors and IPV at three levels: between‐persons, within‐persons across time (wave), and within‐persons across relationships. Relationship quality was associated with IPV mostly at the between‐persons and within‐persons (wave) levels. Couple conflict was associated with all IPV outcomes at all levels. Partner jealousy was more consistently associated with IPV victimization; participant jealousy was more consistently linked with IPV perpetration. These novel findings suggest that, within SGM individuals, IPV may be influenced by relationship quality, destructive conflict, and jealousy as they fluctuate within individuals from relationship to relationship and within individuals over time. As such, these relationship factors represent promising potential targets for interventions to reduce IPV among SGM‐AFAB youth.
Continental Scale Hydrostratigraphy: Comparing Geologically Informed Data Products to Analytical Solutions
Authors: Swilley Jackson S. , Tijerina‐Kreuzer Danielle , Tran Hoang V. , Zhang Jun , Yang Chen , Condon Laura E. , Maxwell Reed M. 
Published: September 2023

AbstractThis study synthesizes two different methods for estimating hydraulic conductivity (K) at large scales. We derive analytical approaches that estimate K and apply them to the contiguous United States. We then compare these analytical approaches to three‐dimensional, national gridded K data products and three transmissivity (T) data products developed from publicly available sources. We evaluate these data products using multiple approaches: comparing their statistics qualitatively and quantitatively and with hydrologic model simulations. Some of these datasets were used as inputs for an integrated hydrologic model of the Upper Colorado River Basin and the comparison of the results with observations was used to further evaluate the K data products. Simulated average daily streamflow was compared to daily flow data from 10 USGS stream gages in the domain, and annually averaged simulated groundwater depths are compared to observations from nearly 2000 monitoring wells. We find streamflow predictions from analytically informed simulations to be similar in relative bias and Spearman's rho to the geologically informed simulations. R‐squared values for groundwater depth predictions are close between the best performing analytically and geologically informed simulations at 0.68 and 0.70 respectively, with RMSE values under 10 m. We also show that the analytical approach derived by this study produces estimates of K that are similar in spatial distribution, standard deviation, mean value, and modeling performance to geologically‐informed estimates. The results of this work are used to inform a follow‐on study that tests additional data‐driven approaches in multiple basins within the contiguous United States.
Preparation of nano SiC by carbothermic reduction of silicon cutting waste with phenolic resin
Authors: Jiang Shengnan , Gao Shuaibo , Zhang Baojie , Xu Xiaoxu , Chen Qifan , Xing Pengfei 
Published: September 2023

AbstractWith the vigorous development of photovoltaic industry, considerable amount of silicon cutting waste (SCW) has been generated and aroused a series of environmental problems. Current recycling methods focus on reutilizing the waste to prepare low‐value industrial Si, Al‐Si alloy, SiC block, and so forth. Herein, we have fully utilized the fine characteristic of SCW to prepare high‐value nano SiC particles with an average diameter of ∼30 nm through carbothermal synthesis at 1500°C for 2 h, and under Ar atmosphere. In the synthesis process, the SCW serves as the Si source and the phenolic resin serves as the C source. The synthesis process mainly includes two stages: the pyrolysis of phenolic resin and the synthesis process. The fine particles of the SCW and the pyrolytic carbon from the phenolic resin contribute to the formation of the nano SiC. Besides, the photoluminescence and Thermal Gravimetric Analyzer (TGA) results show that the obtained SiC nanoparticle possesses a special photoluminescence and a favorable thermal stability.
Copper homeostasis and cuproptosis in cancer immunity and therapy
Authors: Liu Wei‐Qing , Lin Wan‐Rong , Yan Li , Xu Wen‐Hao , Yang Jun 
Published: September 2023

SummaryCopper is an essential nutrient for maintaining enzyme activity and transcription factor function. Excess copper results in the aggregation of lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), which correlates to the mitochondrial tricarboxylic acid (TCA) cycle, resulting in proteotoxic stress and eliciting a novel cell death modality: cuproptosis. Cuproptosis exerts an indispensable role in cancer progression, which is considered a promising strategy for cancer therapy. Cancer immunotherapy has gained extensive attention owing to breakthroughs in immune checkpoint blockade; furthermore, cuproptosis is strongly connected to the modulation of antitumor immunity. Thus, a thorough recognition concerning the mechanisms involved in the modulation of copper metabolism and cuproptosis may facilitate improvement in cancer management. This review outlines the cellular and molecular mechanisms and characteristics of cuproptosis and the links of the novel regulated cell death modality with human cancers. We also review the current knowledge on the complex effects of cuproptosis on antitumor immunity and immune response. Furthermore, potential agents that elicit cuproptosis pathways are summarized. Lastly, we discuss the influence of cuproptosis induction on the tumor microenvironment as well as the challenges of adding cuproptosis regulators to therapeutic strategies beyond traditional therapy.
Improved sequential insertion heuristics for berth allocation problems
Authors: Rodrigues Filipe 
Published: September 2023

AbstractBerth allocation decisions affect all subsequent decisions in port terminals. Thus assigning berthing positions and berthing times to vessels—known as the berth allocation problem (BAP)—is one of the most important problems in port terminals. Because this is an NP‐hard problem, most of the solution methods proposed for solving it are heuristics. Although very different, some heuristics applied to the continuous BAP share a common step usually performed several times: the insertion of vessels from an insertion sequence in the time‐space diagram that represents a BAP solution. This process is frequently done by using minimum cost sequential insertion heuristics such as bottom‐left‐based heuristics. Although fast and simple, these heuristics may not lead to high‐quality solutions. In this paper, we propose improved sequential insertion heuristics that generally outperform the traditional ones and keep their simplicity and speed. The proposed heuristics are tested on a large set of instances of BAPs with different optimization objectives, and the obtained results show that they can lead to solutions up to 70% better than those obtained by traditional sequential insertion heuristics.
In vitro prevention and inactivation of biofilms using controlled‐release iodine foam dressings for wound healing
Authors: Watson Fergus , Chen Rui , Percival Steven L. 
Published: September 2023

AbstractMicrobial biofilms are a major hindrance in the wound healing process, prolonging the inflammatory response phase, thus making them a target in treatment. The aim of this study is to assess the antibacterial properties of commercially available wound dressings, of various material composition and antibacterial agents, towards multiple in vitro microbial and biofilm models. A variety of in vitro microbial and biofilm models were utilised to evaluate the ability of wound dressing materials to sequester microbes, prevent dissemination and manage bioburden. Sequestering and dissemination models were used to evaluate the ability of wound dressing materials to prevent the biofilm‐forming bacterium, Pseudomonas aeruginosa, from migrating through dressing materials over a 24–72 h challenge period. Additionally, Centre for Disease Control (CDC) Bioreactor and Drip Flow models were used to evaluate antibacterial killing efficacy towards established P. aeruginosa and Staphylococcus aureus biofilms using more challenging, wound‐like models. Controlled‐release iodine foam and silver‐impregnated carboxymethylcellulose (CMC) wound dressing materials demonstrated potent biofilm management properties in comparison to a methylene blue and gentian violet‐containing foam dressing. Both the iodine‐containing foam and silver‐impregnated CMC materials effectively prevented viable P. aeruginosa dissemination for up to 72 h. In addition, the controlled‐release iodine foam and silver‐impregnated CMC materials reduced P. aeruginosa bioburden in the Drip Flow model. The controlled‐release iodine foam demonstrated superiority in the CDC Bioreactor model, as both the silver‐ and iodine‐containing materials reduced S. aureus to the limit of detection, but P. aeruginosa growth was only completely reduced by controlled‐release iodine foam dressing materials. The data generated within the in vitro biofilm models supports the clinical data available in the public domain for the implementation of iodine foam dressings for effective biofilm management and control in wound care.
Leaf traits and temperature shape the elevational patterns of phyllosphere microbiome
Authors: Wang Xing , Yuan Zuoqiang , Ali Arshad , Yang Teng , Lin Fei , Mao Zikun , Ye Ji , Fang Shuai , Hao Zhanqing , XugaoWang  , Le Bagousse‐Pinguet Yoann 
Published: September 2023

AbstractAimThe phyllosphere microbiome is central to plant health, distribution, and ecosystem function, yet, we lack a clear understanding of the drivers shaping their diversity in mountain ranges. Here, we examined how the endo‐ and epiphytic phyllosphere microbiomes of mountains simultaneously respond to climate and leaf functional traits.LocationTemperate forests of Changbai Mountain Natural Reserve, China.MethodsWe collected the leaves of dominant tree species along seven elevations from 800 to 1950. We investigated changes in species richness and Shannon diversity of endo‐ and epiphytic phyllosphere fungal and bacterial communities (using next‐generation sequencing of ITS2 and 16S) along an 1150 m elevational gradient. We also examined the direct and indirect effects of climate (mean annual temperature; MAT) and 13 leaf morphological and chemical traits on the microbiome of the phyllosphere.ResultsPhyllosphere microbiome declined monotonically with increasing elevation, contrasting with the hump‐shaped biodiversity patterns that are commonly reported. We observed a steeper decline in epiphytic bacterial diversity than in endophytic bacteria, whereas conversely endophytic fungi diversity declined more dramatically with increasing elevation than epiphytic fungi. Host plant traits – those involved in resource uptake and leaf surface temperature – predominantly shaped the elevational patterns of endophytic phyllosphere microbiome, whereas MAT mostly increased the richness and Shannon diversity of epiphytic organisms. We also observed weak, but significant indirect effects suggesting that host plant traits are important biotic drivers mediating climate effects on endophytic phyllosphere microbiome. Also, no covariation between bacteria and fungi was observed (neither for endophytic nor for epiphytic organisms), supporting neutral associations between bacterial and fungal communities, irrespective of the elevation.Main ConclusionsBoth direct and mediating effects of plant traits should be considered to better understand the drivers shaping the richness and Shannon diversity of endo‐ and epiphytic phyllosphere microbiomes, and more generally the plant–microbe associations. Our study also offers a trait‐based attempt to disentangle the effects of biotic and abiotic filters in shaping endo‐ and epiphytic phyllosphere microbiome along an elevational gradient.
Imeglimin‐mediated glycemic control in maternally inherited deafness and diabetes
Authors: Ishibashi Ryoichi , Hirayama Kiichi , Watanabe Suzuka , Okano Kosuke , Kuroda Yuta , Baba Yusuke , Kanayama Takuma , Ito Chiho , Kasahara Keisuke , Aiba Saki , Iga Ryo , Ohtani Ryohei , Inaba Yosuke , Koshizaka Masaya , Maezawa Yoshiro , Yokote Koutaro 
Published: September 2023

AbstractMitochondrial dysfunction causes maternally inherited deafness and diabetes (MIDD). Herein, we report improved glycemic control in a 47‐year‐old Japanese woman with MIDD using imeglimin without major adverse effects. Biochemical tests and metabolome analysis were performed before and after imeglimin administration. Blood glucose level fluctuations were determined. Sulfonylureas, dipeptidyl peptidase‐4 inhibitors (DPP4is), and sodium glucose transporter‐2 inhibitors (SGLT2i) were administered to evaluate the efficacy of their combination with imeglimin. Imeglimin decreased the HbA1c and ammonia levels and increased the time‐in‐range, C‐peptide reactivity, and glucagon level. Elevated citrulline and histamine levels were decreased by imeglimin. The hypoglycemic effect was not enhanced by imeglimin when combined with sulfonylurea or DPP4i, but the blood glucose level was improved when combined with SGLT2i. Imeglimin improved glucose concentration‐dependent insulin secretion and maximized the insulin secretory capacity by improving mitochondrial function and glutamine metabolism and urea circuit abnormalities by promoting glucagon secretion. Imeglimin could improve glycemic control in MIDD.
Influences of long‐term care insurance on pulmonary and urinary tract infections among older people with disability
Authors: Liu Hongyun , Feng Chuanteng , Yu Bin , Ma Hua , Li Yuchen , Wu Jinhui , Dong Birong , Wang Zihang , Jia Peng , Dou Qingyu , Yang Shujuan 
Published: September 2023

AbstractBackgroundPulmonary infection (PI) and urinary tract infection (UTI) have been the most common cause of hospitalization and most frequent infection respectively in older people with disability (OPWD). Long‐term care insurance (LTCI) policy, intending to provide services to reduce the disease burden of OPWD, it remains unclear whether LTCI could reduce PI‐, and UTI‐related hospitalizations. This quasi‐experimental study aimed to assess the influences of LTCI on all‐cause, especially PI‐ and UTI‐related hospitalizations among OPWD and the variation across sociodemographic characteristics.Methods32,120 participants in the Chengdu Long‐term Care Insurance cohort were considered the intervention group, and 2,704 not covered by the LTCI were in the control group. A total of 3,134,160 hospitalization records were collected between January 2014 and June 2021. A doubly robust difference‐in‐differences (DID) method was used to estimate the average treatment effect on the treated (ATT), indicating the average effect of LTCI on intervention group.ResultsThe average monthly all‐cause, PI‐, and UTI‐related hospitalization rates were 16.3%, 4.0% and 0.5% in the intervention group, respectively, and were 19.3%, 3.9% and 0.5% in the control group, respectively. Under LTCI, all‐cause (ATT [95% CI]: 7.15% [6.41%, 7.88%]), PI‐ (3.25% [2.76%, 3.74%]), and UTI‐related hospitalizations (0.46% [0.28%, 0.64%]) were decreased. The influences of LTCI became significant after 5 months since the LTCI implementation and remained stable over time. The impact was more pronounced among those with longer coverage. The overall reduction was stronger in those who were not married, lived alone, and resided in institutions.ConclusionsLTCI may reduce the occurrence of all‐cause, PI‐, and UTI‐related hospitalizations in OPWD, with stronger influences observed over an extended period of implementation. The implementation of LTCI can play a role in reducing the burden of infectious diseases in OPWD and the care burden of families and society.
The paradoxical position of nurses regarding euthanasia and its legalisation: A descriptive quantitative study
Authors: Ortega‐Galán Ángela María , Ibáñez‐Masero Olivia , Fernández‐Martínez Elia , Ortiz‐Amo Rocío , Fernández‐Santos Laura , Ruiz‐Fernández María Dolores 
Published: September 2023

AbstractAims and ObjectivesTo learn about the attitudes of nurses working in the Andalusian Public Health System regarding euthanasia and its legalisation.BackgroundEuthanasia often finds itself in the crosshairs of ethical and political debate on an international scale. Currently, the Spanish Organic Law 3/2021 of 24 March, 2021, recognises euthanasia as a fundamental right in Spain. It is of particular interest to know about the views, attitudes and stances that Andalusian nurses have of euthanasia as they are key players within the framework of euthanasia and administration of life‐ending drugs. They play a central role in guiding patients through the euthanasia application process.DesignObservational descriptive study.MethodsA study of Andalusian Public Health System nurses was carried out using non‐probability convenience sampling. 518 nurses with an average age of 44.75 years answered in a questionnaire that was distributed on an online platform. Socio‐demographic and occupational variables were assessed, together with the Death Anxiety Scale and the Euthanasia Attitude Scale. A bivariate analysis and a multivariate linear regression model were performed. The STROBE checklist was used.ResultsThe mean score obtained on the Euthanasia Attitude Scale was 75.95 (SD = 16.53). The mean score obtained on the Death Anxiety Scale was 7.56 (SD = 3.05). The variables age and work experience were negatively correlated with the total scores of the Euthanasia Attitude Scale and the categories ‘Ethical considerations’, ‘Practical considerations’ and ‘Treasuring life’. On the other hand, there was a significant positive correlation between age and work experience and ‘Spiritual beliefs’ category.ConclusionsThe current situation shows a worrying paradox. There is a stark difference between positive professional attitudes towards euthanasia and the desire to participate in its application.Relevance to Clinical PracticeIt is vital that educational and healthcare institutions make the necessary efforts to ensure that nurses develop sound moral judgement, displaying the moral conscience and ethical commitment required of this established profession.Patient or Public ContributionNo patient or public contribution.
Accentuating the positive: How and when occupational identity threat leads to job crafting and positive outcomes
Authors: Wang Yangxin , Lau Dora C. , Kim Youngsang 
Published: September 2023

AbstractDrawing on the identity literature and job crafting research, the present work investigates how occupational identity threat is positively related to individual job crafting (i.e., approach crafting and avoidance crafting) and how approach (or avoidance) crafting transforms occupational identity threat into increased job engagement and improved job performance. We also propose that the regulatory focus of individuals would moderate these relationships. After conducting two field studies, Study 1, which used data from 211 matched employee–supervisor pairs at an aluminium manufacturing company, found that occupational identity threat had a positive effect on approach and avoidance crafting. The results also showed further support for the moderating effect of prevention focus and a mediating effect of approach crafting in transferring the effect of occupational identity threat in a positive manner (i.e., higher job engagement and performance). In Study 2, we replicated the findings of Study 1 and found further evidence for the moderating effect of promotion focus and a moderated mediating effect of approach crafting on job engagement. Theoretical and practical implications of this research are discussed.