bluuebunny/crossref_metadata_2025_split huggingface dataset:
20-hydroxyecdysone Upregulates Ecdysone Receptor (ECR) Gene to Promote Pupation in the Honeybee, Apis mellifera Ligustica
Authors: Yu Jing , Song Hongyu , Wang Ying , Liu Zhenguo , Wang Hongfang , Xu Baohua 
Published: June 2023

Synopsis
A heterodimeric complex of two nuclear receptors, the ecdysone receptor (ECR) and ultraspiracle (USP), transduces 20-hydroxyecdysone (20E) signaling to modulate insect growth and development. Here, we aimed to determine the relationship between ECR and 20E during larval metamorphosis and also the specific roles of ECR during larval–adult transition in Apis mellifera. We found that ECR gene expression peaked in the 7-day-old larvae, then decreased gradually from the pupae stage. 20E slowly reduced food consumption and then induced starvation, resulting in small-sized adults. In addition, 20E induced ECR expression to regulate larval development time. Double-stranded RNAs (dsRNAs) were prepared using common dsECR as templates. After dsECR injection, larval transition to the pupal stage was delayed, and 80% of the larvae showed prolonged pupation beyond 18 h. Moreover, the mRNA levels of shd, sro, nvd, and spo, and ecdysteroid titers were significantly decreased in ECR RNAi larvae compared with those in GFP RNAi control larvae. ECR RNAi disrupted 20E signaling during larval metamorphosis. We performed rescuing experiments by injecting 20E in ECR RNAi larvae and found that the mRNA levels of ECR, USP, E75, E93, and Br-c were not restored. 20E induced apoptosis in the fat body during larval pupation, while RNAi knockdown of ECR genes reduced apoptosis. We concluded that 20E induced ECR to modulate 20E signaling to promote honeybee pupation. These results assist our understanding of the complicated molecular mechanisms of insect metamorphosis.
Mechanosensory Feedback in Lamprey Swimming Models and Applications in the Field of Spinal Cord Regeneration
Authors: Katz Hilary R , Hamlet Christina L 
Published: June 2023

Synopsis
The central pattern generator (CPG) in anguilliform swimming has served as a model for examining the neural basis of locomotion. This system has been particularly valuable for the development of mathematical models. As our biological understanding of the neural basis of locomotion has expanded, so too have these models. Recently, there have been significant advancements in our understanding of the critical role that mechanosensory feedback plays in robust locomotion. This work has led to a push in the field of mathematical modeling to incorporate mechanosensory feedback into CPG models. In this perspective piece, we review advances in the development of these models and discuss how newer complex models can support biological investigation. We highlight lamprey spinal cord regeneration as an area that can both inform these models and benefit from them.
In situ reconstruction of an infected infrarenal aortic pseudoaneurysm and arteriovenous fistula with self-made pericardium graft
Authors: Yang Guangmin , Sun Tao , Chen Hongwei , Zhang Leiyang 
Published: June 2023

Abstract
Infectious aortic disease is a challenging life-threatening disease in cardiovascular surgery. A 70-year-old man patient presented with an infected infrarenal aortic pseudoaneurysm and right iliac artery- left iliac vein fistula (arteriovenous fistula). He underwent total infected tissues excision, debridement, in situ reconstructions of the aorta using a self-made pericardium graft with omental coverage and arteriovenous fistula patch repair to prevent leakage. One-year follow-up revealed the absence of clinically relevant infection with patency of the graft and the absence of biochemical inflammatory markers.
Medicines use issues perceived by Arabic-speaking patients living in English-speaking countries: A systematic review
Authors: Sawalha Rawan , Hosseinzadeh Hassan , Bajorek Beata 
Published: June 2023

Abstract

Objectives
Quality use of medicines, or rational medicines use, requires patients’ adherence to the quality principles of medication use. There is a limited number of reviews about quality medication use among migrant patients. This review aims to fill this gap by exploring medication-related issues experienced by Arabic-speaking patients living in English-speaking countries.

Methods
The searched databases included WebMD, EMBASE, Scopus, CINHAL, PubMed/Medline and Web of science.

Key findings
The initial search retrieved 2071 publications and 23 publications met the inclusion criteria. Our review found that the most frequently reported medication-related issues among Arabic-speaking patients residing in English-speaking countries were problems related to decision-making regarding treatment options, inappropriate counselling and lack of information about medicines and diseases, lack of monitoring and follow-up, and intentional and unintentional medication non-adherence. Informed by the bio-psycho-socio-systems model, contributing factors to the medication issues included used coping strategies, ethno-cultural and religious beliefs and ineffective relationships with healthcare providers.

Conclusions
Our review suggests that cultural factors can significantly influence individuals’ perceptions and actions around the use of medication. Thus, healthcare providers need to be mindful of the specific cultural affiliations of ethnic minorities and exhibit cultural sensitivity when prescribing medication to migrant patients to foster a better relationship between patients and healthcare providers. Applying a patient-centred approach using shared decision-making can help. Our findings also suggest that pharmacy practice is critical in improving medication safety among Arabic-speaking patients.
Disease and Dissent: Epidemics as a Catalyst for Social Unrest
Authors: Cordell Rebecca , Wood Reed M , Wright Thorin M 
Published: June 2023

AbstractWe identify a set of potential theoretical mechanisms that link the outbreak and spread of communicable diseases to temporal and spatial patterns of social unrest. Despite the proliferation of research since 2020 analyzing the social impact of the Covid-19 pandemic, we examine the broader relationship between less severe epidemic outbreaks and their social consequences. Epidemics, as well as the policies that governments implement to tackle them, often generate acute grievances among the public and create new opportunities for collective dissent, the combination of which promotes unrest. Nonetheless, perceived opportunities for unrest are influenced by the scale and scope of the disease outbreak, and particularly lethal disease outbreaks may therefore offset the incentives for collective mobilization. We examine these relationships using sub-national data on communicable disease outbreaks and geo-located social unrest events data in 60 African and Latin American countries from 1990 to 2017 and find support for our argument. However, we observe a curvilinear relationships between the severity of the epidemic and the incidence of unrest.
Mapping and Unpacking Global Governance Bodies: A Cross Sectional and Cross Organizational Analysis
Authors: Saz-Carranza Angel , Maggetti Martino , Yesilkagit Kutsal , Coen David 
Published: June 2023

Abstract
Several recent studies have pointed to the increasing relevance of relatively informal, non-treaty-based global governance bodies (GGBs). Yet, a systematic fine-grained assessment of these bodies and their implications for global governance are still pending. To what extent, do non-treaty-based GGBs constitute a truly novel type of governance body, distinct from traditional treaty-based international organizations (IOs)? How do the distinctive features of GGBs affect their role in global governance? To what extent are GGB’s patterns of emergence and development specific to policy sectors? This article tackles these questions, drawing on an original dataset on GGBs in five distinct policy areas (banking and finance, energy, global health, Internet, and migration policy). We combine a micro-organizational perspective with a meso-level network approach to unpack the main features of non-treaty-based GGBs vis-à-vis, traditional IOs. Our results provide support to the general expectation that non-treaty-based GGBs offer distinctive opportunities for global governance with respect to traditional IOs. However, importantly, this relationship is not dichotomous. We find that GGBs exist on a continuum of fit-to-purpose designs ranging from hard, formal, and intergovernmental models to a soft, informal, and multistakeholder-based form of governance. Lastly, we also find notable variations across policy areas, where global health stands out given its decentralized network structure.
Speaking of Epistemic Injustice: A Reply
Authors: Hopman Marieke Janne , Jama Guleid Ahmed , Zvonareva Olga , Hoļavins Artūrs ,   Anonymous
Published: June 2023

Abstract
In this article, we reply to ‘Ethics and Epistemic Injustice in the Global South’ (Kaur et al. 2023), a response to the original article ‘Covert Qualitative Research as a Method to Study Human Rights Under Authoritarian Regimes’ (Hopman 2022). Our reply is written by authors who have expertise and direct experience with the issues at stake (authoritarianism, Global North/Global South relations, covert research methods, epistemic injustice). We show that while there are some interesting points raised in the response article, in general, it does not do justice to the arguments presented in the original article. Instead it constructs a ‘straw man’ by misrepresenting claims in the original article, attributing to it assumptions that were not there, and lumping together notions such as authoritarian zones and Global South, that were not equated in the original article. After providing arguments for this position and discussing the main topics of the critique, we present two new elements: first, a contribution by someone from Moroccan controlled Western Sahara (MCWS), who experienced covert research as a research participant. Second, an overview of lessons learned from this exchange. These include: 1) instead of authoritarian zones, ‘authoritarian situations’ is a more appropriate concept; 2) projects using covert research should strive to include overt and participatory elements; 3) a response article alleging epistemic injustice should create space for the people concerned to speak for themselves.
Effects of sample collection and storage methods on fecal bacterial diversity in California ground squirrels (Otospermophilus beecheyi)
Authors: Person Erin S , von Maydell Kianna P , Baldoza Jada E , Lacey Eileen A , Smith Jennifer E 
Published: June 2023

Abstract
Measures of fecal bacterial abundance and taxonomic composition are commonly used as proxies for gut microbial diversity in studies of free-living mammals. Because methods of sample collection and storage may affect measures of bacterial diversity, we evaluated the effects of several procedures on fecal bacterial diversity in a free-living population of California ground squirrels (Otospermophilus beecheyi). Replicate fecal samples from 12 adult female squirrels were collected either from the soil beneath traps in which individuals had been captured or from tubs placed under squirrels during handling. Samples were then either frozen immediately in liquid nitrogen or stored on ice for several hours before being transferred to a −80°C freezer. Sequencing of the bacterial 16s RNA gene revealed no differences among methods with regard to sequence read depth (number of sequences recovered per animal) or alpha (within-individual) diversity of bacterial taxa. While our collection-storage procedures had a significant effect on one of the metrics of beta (among-individual) bacterial diversity examined, this effect was small compared to that of individual identity. Date of sample collection affected alpha and beta diversity; samples collected only 1 week apart differed significantly in bacterial diversity. Overall, these findings suggest that the collection and storage methods employed yield generally comparable information and are capable of capturing potentially important patterns of fecal bacterial composition and diversity in free-living mammals.
Efficacy of aural detection methods for detecting Northern Pika (Ochotona hyperborea) occupancy in rocky and densely vegetated habitats
Authors: Sakiyama Tomoki , García Molinos Jorge 
Published: June 2023

Abstract
Wildlife monitoring plays a key role in species conservation, with growing importance under the threat of climate change. The Northern Pika (Ochotona hyperborea) is a cold-adapted species found in Hokkaido, Japan, presumably vulnerable to such threats. However, its high elusiveness hinders detailed population surveys, and visual detection methods—often used for other pika species—are not applicable to its densely vegetated habitats. In this study, we assessed the efficacy of aural detection methods to survey the occupancy of Northern Pika through their distinct vocalizations. We conducted two types of point-count surveys—auditory observation and playback—during 2021 at 18 sites in and around Daisetsuzan National Park. We then assessed the efficacy of these methods in detecting presence and compared time until first detection of the animal. The Northern Pika was present at 11 of all surveyed sites, with a predominance at higher elevations. Our results suggest that both auditory observation and playback are effective at detecting presence, but playback is more time-efficient. We discuss the advantages and disadvantages of each method given these results. In conclusion, our results demonstrate that both survey methods are applicable for Northern Pika population surveys—even in densely vegetated habitats—representing valid and affordable survey methods that can help to improve current monitoring and conservation efforts, and will be of increasing value given potentially negative effects of climate change on persistence of the species.
Large-scale data-driven and physics-based models offer insights into the relationships among the structures, dynamics, and functions of chromosomes
Authors: Feng Cibo , Wang Jin , Chu Xiakun 
Published: June 2023

Abstract
The organized three-dimensional chromosome architecture in the cell nucleus provides scaffolding for precise regulation of gene expression. When the cell changes its identity in the cell-fate decision-making process, extensive rearrangements of chromosome structures occur accompanied by large-scale adaptations of gene expression, underscoring the importance of chromosome dynamics in shaping genome function. Over the last two decades, rapid development of experimental methods has provided unprecedented data to characterize the hierarchical structures and dynamic properties of chromosomes. In parallel, these enormous data offer valuable opportunities for developing quantitative computational models. Here, we review a variety of large-scale polymer models developed to investigate the structures and dynamics of chromosomes. Different from the underlying modeling strategies, these approaches can be classified into data-driven (‘top-down’) and physics-based (‘bottom-up’) categories. We discuss their contributions to offering valuable insights into the relationships among the structures, dynamics, and functions of chromosomes and propose the perspective of developing data integration approaches from different experimental technologies and multidisciplinary theoretical/simulation methods combined with different modeling strategies.
Revealing ‘invisible’ poetry by W. H. Auden through computer vision: Using photometric stereo to visualize indented impressions
Authors: Brenner Simon , Frühwirth Timo , Mayer Sandra 
Published: June 2023

AbstractThis article explores the use of computer-vision technologies in the context of digitally editing and researching letters and literary papers by the British-American poet W. H. Auden. Two documents in the previously inaccessible ‘Auden Musulin Papers’ contain colourless indented typewriter impressions of poetry. These impressions result from the papers’ original use as ‘backing sheets’, inserted into a typewriter below those sheets of paper on which Auden typed his poetry. Subsequently, these backing sheets were reused in the poet’s ‘working correspondence’ to Welsh-Austrian writer Stella Musulin. While standard image-digitization technologies fail to capture these 3D indented impressions, they can successfully be represented by means of Photometric Stereo, which has been fruitfully employed in the research of 3D cultural-heritage objects. Following a detailed outline of this method, this article demonstrates how Photometric Stereo can help to reconstruct poetry that has survived only in the form of indented impressions. Thus, the case study illustrates how computer vision can contribute to our understanding both of ‘poetic’ practices of composition and revision as well as of ‘material’ writing practices. It also has wide-ranging implications for re-conceptualizing sheets of paper as 3D objects in the research of literary documents from the twentieth century.
A subarcsec localized fast radio burst with a significant host galaxy dispersion measure contribution
Authors: Caleb M , Driessen L N , Gordon A C , Tejos N , Bernales L , Qiu H , Chibueze J O , Stappers B W , Rajwade K M , Cavallaro F , Wang Y , Kumar P , Majid W A , Wharton R S , Naudet C J , Bezuidenhout M C , Jankowski F , Malenta M , Morello V , Sanidas S , Surnis M P , Barr E D , Chen W , Kramer M , Fong W , Kilpatrick C D , Prochaska J Xavier , Simha S , Venter C , Heywood I , Kundu A , Schussler F 
Published: June 2023

ABSTRACT
We present the discovery of FRB 20210410D with the MeerKAT radio interferometer in South Africa, as part of the MeerTRAP commensal project. FRB 20210410D has a dispersion measure DM = 578.78 ± 2 ${\rm pc \, cm^{-3}}$ and was localized to subarcsec precision in the 2 s images made from the correlation data products. The localization enabled the association of the FRB with an optical galaxy at z = 0.1415, which when combined with the DM places it above the 3σ scatter of the Macquart relation. We attribute the excess DM to the host galaxy after accounting for contributions from the Milky Way’s interstellar medium and halo, and the combined effects of the intergalactic medium and intervening galaxies. This is the first FRB that is not associated with a dwarf galaxy to exhibit a likely large host galaxy DM contribution. We do not detect any continuum radio emission at the FRB position or from the host galaxy down to a 3σ rms of 14.4 $\mu$Jy beam−1. The FRB has a scattering delay of $29.4^{+2.8}_{-2.7}$ ms at 1 GHz, and exhibits candidate subpulses in the spectrum, which hint at the possibility of it being a repeating FRB. Although not constraining, we note that this FRB has not been seen to repeat in 7.28 h at 1.3 GHz with MeerKAT, 3 h at 2.4 GHz with Murriyang, and 5.7 h at simultaneous 2.3 GHz and 8.4 GHz observations with the Deep Space Network. We encourage further follow-up to establish a possible repeating nature.
New evidence for the precession of tilted disc in SDSS J081256.85+191157.8
Authors: Sun Qi-Bin , Qian Sheng-Bang , Zhu Li-Ying , Liao Wen-Ping , Zhao Er-Gang , Li Fu-Xing , Shi Xiang-Dong , Li Min-Yu 
Published: June 2023

ABSTRACT
Superorbital signals and negative superhumps are thought to be related to the reverse precession of the nodal line in a tilted disc, but the evidence is lacking. Our results provide new evidence for the precession of the tilted disc. Based on the TESS and K2 photometry, we investigate the superorbital signals, negative superhumps, positive superhumps, and eclipse characteristics of the long-period eclipsing cataclysmic variable star SDSS J0812. We find superorbital signals, negative superhumps, and positive superhumps with periods of 3.0451(5) d, 0.152047(2) d, and 0.174686 (7) d, respectively, in the K2 photometry, but all disappear in the TESS photometry, where the positive superhumps are present only in the first half of the same campaign, confirming that none of them is permanently present in SDSS J0812. In addition, we find for the first time a cyclic variation of the O-C of minima, eclipse depth, and negative superhumps amplitudes for 3.045 (8) d, 3.040(6) d, and 3.053 (8) d in SDSS J0812, respectively, and all reach the maximum at ∼0.75 precession phases of the tilted disc, which provides new evidence for the precession of the tilted disc. We suggest that the O-C and eclipse depth variations may come from a shift of the brightness centre of the precession tilted disc. Our first finding on the periodic variation of negative superhumps amplitude with the superorbital signals is significant evidence that the origin of negative superhumps is related to the precession of the tilted disc.
The Cosmic Ultraviolet Baryon Survey (CUBS) – VI. Connecting physical properties of the cool circumgalactic medium to galaxies at z ≈ 1
Authors: Qu Zhijie , Chen Hsiao-Wen , Rudie Gwen C , Johnson Sean D , Zahedy Fakhri S , DePalma David , Boettcher Erin , Cantalupo Sebastiano , Chen Mandy C , Cooksey Kathy L , Faucher-Giguère Claude-André , Li Jennifer I-Hsiu , Lopez Sebastian , Schaye Joop , Simcoe Robert A 
Published: June 2023

ABSTRACT
This paper presents a newly established sample of 19 unique galaxies and galaxy groups at redshift z = 0.89–1.21 in six QSO fields from the Cosmic Ultraviolet Baryon Survey (CUBS), designated as the CUBSz1 sample. In this sample, nine galaxies or galaxy groups show absorption features, while the other 10 systems exhibit 2σ upper limits of $\log N (\rm{He\,{\small I}})/\mbox{${\rm cm^{-2}}$}\lesssim 13.5$ and $\log N (\rm{O\,{\small V}})/\mbox{${\rm cm^{-2}}$}\lesssim 13.3$. Environmental properties of the galaxies, including galaxy overdensities, the total stellar mass and gravitational potential summed over all neighbours, and the presence of local ionizing sources, are found to have a significant impact on the observed CGM absorption properties. Specifically, massive galaxies and galaxies in overdense regions exhibit a higher rate of incidence of absorption. The CGM absorption properties in galaxy groups appear to be driven by the galaxy closest to the QSO sightline, rather than by the most massive galaxy or by mass-weighted properties. We introduce a total projected gravitational potential ψ, defined as −ψ/G = ∑Mhalo/dproj summed over all group members, to characterize the galaxy environment. This projected gravitational potential correlates linearly with the maximum density detected in each sightline (i.e. a power-law slope of $0.95_{-0.14}^{+0.15}$), consistent with higher pressure gas being confined in deeper gravitational potential wells. In addition, we find that the radial profile of cool gas density exhibits a decline from the inner regions to the outskirts, and the amplitude is consistent with the cool gas being in pressure balance with the hot halo. Finally, we note that the ionizing flux from nearby galaxies can elevate the N(H i)/N(He i) ratio, which provides a unique diagnostic of possible local sources contributing to the ionizing radiation field.