bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
Authors: Yu Dongsheng , Li Jiye , Wang Yu , Guo Danfeng , Zhang Xiaodan , Chen Mingming , Zhou Zheng 
Published: December 2022

AbstractAcetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome inhibitor, ameliorates APAP‐induced ALI through an unclear molecular mechanism. This study found that Ori decreased hepatic cytochrome P450 2E1 level and increased glutathione content to prevent APAP metabolism, and then reduced the necrotic area, improved liver function, and inhibited APAP‐induced proinflammatory cytokines and oxidative stress. Ori also decreased activating transcription factor 4 (ATF4) protein levels and increased peroxisome proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α) to reduce APAP‐induced endoplasmic reticulum stress activation and mitochondrial dysfunction. Furthermore, western blot and luciferase assay found that ATF4 inhibited transcription in the PGC‐1α promoter −507 to −495 region to reduce PGC‐1α levels, while ATF4 knockdown neutralized the hepatoprotective effect of Ori. Molecular docking showed that Ori bound to ATF4's amino acid residue glutamate 302 through 6, 7, and 18 hydroxyl bands. Our findings demonstrated that Ori prevented metabolic activation of APAP and further inhibited the ATF4/PGC‐1α pathway to alleviate APAP overdose‐induced hepatic toxicity, which illuminated its potential therapeutic effects on ALI.
Renal fluid and acid/base balance during refeeding in restrictive eating disorders
Authors: Rosen Elaine , Wiley Evan , Hung Phoebe , Song Dana , Sharma Yamini , Moscicki Anna‐Barbara , Wesseling‐Perry Katherine 
Published: December 2022

AbstractBackground and ObjectivesFluid shifts have been ascribed to central diabetes insipidus in patients with anorexia nervosa hospitalized for refeeding. Recent data, however, suggest that vasopressin production is not dysregulated in this population. Our objective was to describe the trajectory of fluid imbalances in relationship to kidney function, electrolyte disturbances, and acid/base balance during refeeding.MethodsA retrospective review of daily fluid balance and biochemical values was performed in 70 sequential unique patients admitted to University of California at Los Angeles Hospital Medical Stabilization Program for Eating Disorders from December 2018 to November 2020.ResultsParticipants (2 males/68 females) were between 10 and 24 years of age and with a median body mass index of 16.1 (14.3, 18.1) kg/m2. A severe negative fluid balance (>−900 ml/day) was observed in 80% of patients at some point during hospitalization. Serum sodium concentrations were normal on admission and remained stable during refeeding. Serum bicarbonate concentrations were 25 ± 1 mEq/dl on admission and increased above the normal range in 31% of patients. Metabolic alkalosis was inversely associated with the development of a negative fluid balance. Estimated glomerular filtration rate was impaired in 54% of patients, improved with refeeding, and was not associated with the development of a severe negative fluid balance or metabolic alkalosis.DiscussionChronic energy deprivation alters the physiology of renal fluid and bicarbonate handling in ways that are independent of vasopressin and glomerular filtration. Further studies are warranted to understand the renal adaptations that occur during energy restriction and subsequent refeeding.Public SignificanceMassive urinary fluid losses occur in patients with restrictive eating disorders hospitalized for refeeding. In addition, many patients have impaired renal bicarbonate excretion. These findings suggest that chronic energy deprivation impairs the kidney's ability to handle the shifts in fluid and acid/base balance that occur when appropriate oral nutrition is re‐introduced.
Emotion word use patterns and eating disorder symptoms: Considering the circumplex model of affect and basic emotions theory
Authors: Romano Kelly A. , Heron Kristin E. , Ferguson Giselle , Scott Stacey B. 
Published: December 2022

AbstractObjectiveNo prior research has examined whether the types of emotion words individuals use to describe their affective experiences cluster along affective dimensions inherent within leading affect theories, or how such emotion word use maps onto eating disorder (ED) symptoms.MethodTo address these gaps, latent profile analysis was used to empirically‐identify groups of young adults (N = 352) by how often they use emotion words characterized by the circumplex model of affect's valence‐arousal dimensions and basic emotions theory's basic versus complex emotion word categorizations. Auxiliary analyses examined differences in groups' ED symptoms (binge eating, purging, restricting, excessive exercising, muscle building, body dissatisfaction, and cognitive restraint).ResultsThe 5‐profile valence‐arousal model and 4‐profile basic‐complex model were the best‐fitting theoretically‐supported solutions. Valence‐arousal profiles with greater negative affect valence generally exhibited worse ED pathology than others, whereas profiles with greater positive affect valence produced inconsistent risk‐ and protective‐factor relations with distinct ED symptoms. Basic‐complex profiles characterized by frequent use of both basic and complex emotion words generally had the greatest ED severity, and profiles with greater basic emotion word use exhibited elevated binge eating.DiscussionIndividual‐differences in young adults' emotion word use patterns, versus sample‐level averages only, warrant further consideration in ED prevention and research.Public SignificanceThe present findings suggest that young adults differ in the types of words they use to describe their emotional experiences, and that these unique emotion word use patterns are linked to distinct eating disorder symptoms. These sources of variation warrant further consideration in eating disorders prevention efforts and future research seeking to advance affect‐based eating disorders theories.
The effect of decreasing human activity from COVID‐19 on the foraging of fallen fruit by omnivores
Authors: Osugi Shigeru , Baek Seungyun , Naganuma Tomoko , Tochigi Kahoko , Allen Maximilian L. , Koike Shinsuke 
Published: December 2022

AbstractIn 2020, a lockdown was implemented in many cities around the world to contain the COVID‐19 pandemic, resulting in a significant cessation of human activity which have had a variety of impacts on wildlife. But in many cases, due to limited pre‐lockdown information, and there are limited studies of how lockdowns have specifically affected behaviors. Foraging behavior is inherently linked to fitness and survival, is particularly affected by changes in temporal activity, and the influence of human disturbance on foraging behavior can be assessed quantitatively based on foraging duration and quantity. The purpose of this study was to determine whether and how the fruit‐foraging behaviors of two omnivores, the Japanese badger (Meles anakuma) and the raccoon dog (Nyctereutes procyonoides), were influenced by the decrease of human activity associated with lockdowns. Specifically, by comparing to a previous study in 2019–2020, we attempted to determine (1) whether foraging behavior increases during the daytime? (2) whether the duration of foraging per visit increases? and (3) what factors animals select for in fruiting trees? The results of the initial investigation showed that the foraging behavior of both species in 2019 was almost exclusively restricted to the nighttime. But as opportunities for foraging behavior without human interference increased in 2020 due to the lockdown, both species (but especially raccoon dogs) showed substantial changes in their activity patterns to be more diurnal. The duration of foraging per visit also increased in 2020 for both species, and the selection during foraging for both species shifted from selecting trees that provided greater cover in 2019 to trees with high fruit production in 2020. Our results show how human activity directly affects the foraging behavior of wildlife in an urban landscape.
Strong species structure but weak geographical structure in demersal Lake Victoria cichlids
Authors: van Rijssel Jacco C. , Moser Florian N. , Mwaiko Salome , Seehausen Ole 
Published: December 2022

AbstractStudying phenotypic and genetic differentiation between very young species can be very informative with regard to learning about processes of speciation. Identifying and characterizing genetic species structure and distinguishing it from spatial genetic structure within a species is a prerequisite for this and is often not given sufficient attention. Young radiations of cichlid fish are classical speciation study systems. However, it is only during the past decade that population genomics based on next‐generation sequencing has begun to provide the power to resolve species and distinguish speciation from spatial population structure for the youngest of these radiations. The Lake Victoria haplochromine cichlids constitute the youngest large cichlid fish radiation, probably <20,000 years old. Earlier work showed that communities of rocky reef cichlids are composed of many reciprocally monophyletic species despite their very recent origins. Here, we build on this work by studying assemblages of offshore demersal cichlids, adding analyses of within‐species spatial structure to the sympatric species structure. We sampled seven multispecies communities along a 6‐km‐long transect from one side of the Mwanza Gulf to the other side. We investigated whether phenotypically diagnosed putative species are reciprocally monophyletic and whether such monophyly is stable across species geographic ranges. We show that all species are genetically strongly differentiated in sympatry, that they are reciprocally monophyletic, and that monophyly is stable across distribution ranges. We found significant differentiation between geographically distinct populations in two species, but no or weak isolation by distance. We further found subtle but significant morphological differences between all species and a linear relationship between genomic and morphological distance which suggests that differences in morphology begin to accumulate after speciation has already affected genome‐wide restrictions of gene flow.
Synthesis of [60]Fullerene Hybrids Endowed with Steroids and Monosaccharides: Theoretical Underpinning as Promising anti‐SARS‐CoV‐2 Agents
Authors: Lemos Reinier , Makowski Kamil , Almagro Luis , Tolón Blanca , Rodríguez Hortensia , Herranz M. Ángeles , Molero Dolores , Martín Nazario , Suárez Margarita 
Published: December 2022

AbstractCyclopropanation reactions between C60 and different malonates decorated with monosaccharides and steroids using the Bingel‐Hirsch methodology have allowed the obtention of a new family of hybrid compounds in good yields. A complete set of instrumental techniques has allowed us to fully characterize the hybrid derivatives and to determine the chemical structure of monocycloadducts. Besides, the proposed structures were investigated by cyclic voltammetry, which evidenced the exclusive reductive pattern of fullerene Bingel‐type monoadducts. Theoretical calculations at the DFT‐D3(BJ)/PBE 6‐311G(d,p) level of the synthesized conjugates predict the most stable conformation and determine the factors that control the hybrid molecules′ geometry. Some parameters such as polarity, lipophilicity, polar surface area, hydrophilicity index, and solvent‐accessible surface area were also estimated, predicting its potential permeability and capability as cell membrane penetrators. Additionally, a molecular docking simulation has been carried out using the main protease of SARS‐CoV‐2 (Mpro) as the receptor, thus paving the way to study the potential application of these hybrids in biomedicine.
Oral capsules of tetra‐hydro‐cannabinol (THC), cannabidiol (CBD) and their combination in peripheral neuropathic pain treatment
Authors: Zubcevic Kanita , Petersen Merete , Bach Flemming Winther , Heinesen Aksel , Enggaard Thomas Peter , Almdal Thomas Peter , Holbech Jakob Vormstrup , Vase Lene , Jensen Troels Stahelin , Hansen Christian Stevns , Finnerup Nanna Brix , Sindrup Søren H. 
Published: December 2022

AbstractBackgroundCannabinoids are often prescribed for neuropathic pain, but the evidence‐based recommendation is ‘weak against’.ObjectivesThe aim was to examine the effect of two cannabinoids and their combination in peripheral neuropathic pain.MethodsThis was a randomized, double‐blind, trial with treatment arms for cannabidiol (CBD), tetra‐hydro‐cannabinol (THC), CBD and THC combination (CBD/THC), and placebo in a 1:1:1:1 ratio and flexible drug doses (CBD 5–50 mg, THC 2.5–25 mg, and CBD/THC 5 mg/2.5 mg–50 mg/25 mg). Treatment periods of 8‐week duration were proceeded by 1 week for baseline observations. Patients with painful polyneuropathy, post‐herpetic neuralgia and peripheral nerve injury (traumatic or surgical) failing at least one previous evidence‐based pharmacological treatment were eligible for inclusion. The primary outcome was the change in weekly average of daily pain measured with a numeric rating scale (NRS). Trail Making Test (TMT) was used as one of the tests of mental functioning.ResultsIn all, 145 patients were included in the study of which 118 were randomized and 115 included in the intention‐to‐treat analysis. None of the treatments reduced pain compared to placebo (p = 0.04–0.60). Effect sizes as estimated in week 8 (positive values worse and negative better than placebo) were CBD mean 1.14 NRS points (95% CI 0.11–2.19), THC 0.38 (CI −0.65 to 1.4) and CBD/THC −0.12 (−1.13 to 0.89).ConclusionsCBD, THC and their combination did not relieve peripheral neuropathic pain in patients failing at least one previous evidence‐based treatment for neuropathic pain.
Regulation and impact of VOC and CO2 emissions on low‐carbon energy systems resilient to climate change: A case study on an environmental issue in the oil and gas industry
Authors: Fetisov Vadim , Gonopolsky Adam M. , Davardoost Hadi , Ghanbari Ata Rezapour , Mohammadi Amir H. 
Published: December 2022

AbstractThe impact of emissions from the fuel and energy sectors adversely affects the environment on the economies of countries. One of these pollutants is volatile organic compounds (VOCs), which contribute to the formation of tropospheric ozone. Emissions of hydrocarbon formation in the form of VOCs occur in four stages of the fuel and energy industry sector: (1) production, (2) processing, (3) transportation, and (4) storage. The oil and gas industry ranks among the top polluting industries in terms of VOC emissions. Research on the negative impact of VOCs, as well as CO2 emissions from the consequences of the extraction, processing, transport, and storage of oil and gas on the ecosystem of the planet and the population, has begun to be studied by science recently. Typically, these studies were conducted using laboratory and field analyses, as well as using data on anthropogenic emissions in the development of regulatory documents and requirements governing the control of VOC and CO2 emissions in the oil and gas industry. This paper presents a critical analysis of the literature on research on the negative effects of VOC emissions on the ecosystem and human health because of such factors as production, processing, transportation, and storage of hydrocarbons. This analysis shows the global magnitude of VOC emissions. Data from human‐made emissions from the oil and gas industry and direct emissions from transportation and energy processing were used to figure out how VOCs affect the environment around the world and how far they spread. In conclusion, this study found patterns of VOC emissions that show how important it is to control VOCs during the production, processing, transportation, and storage of oil and gas, as well as how important it is to create a single research base on emissions for each industry sector and on sources of greenhouse gas absorption.
Design and key technology of the energy consumption management system for the liquid cooling data center
Authors: Lai Yibo , Fang Xiang , Han Rongjie , Xuan Yi , Huang Jiabin 
Published: December 2022

AbstractIn view of the serious problem of energy consumption waste in the application process of liquid cooling data center, a new energy consumption management system of liquid cooling data center is constructed in this research. Energy consumption predictor, resource controller and resource configurator are used to monitor and manage energy consumption and optimize resource allocation of liquid cooling data center. The S3C2440A microprocessor with the internal core of ARM920T is adopted as the core controller of the energy consumption data collection system, and the energy consumption sampling circuit is designed with the voltage transformer and the current transformer, and attenuation network is adopted to prevent frequency aliasing in data sampling. Particle swarm optimization algorithm is used to identify the parameters in the model estimator, and the resource coordinator is used to solve the power consumption and the performance models. When using multiple physical servers to simulate the data center environment, the experimental structure shows that the system in the research can control the overall energy consumption of the server within 260 W, and the prediction error of the model estimator is kept lower than 2.4%.
5G network slicing with unmanned aerial vehicles: Taxonomy, survey, and future directions
Authors: Bouzid Tarek , Chaib Noureddine , Bensaad Mohamed Lahcen , Oubbati Omar Sami 
Published: December 2022

AbstractWith the ever‐expanding rise of network demands and user expectations, the fifth generation (5G) of cellular networks was envisioned to support a plethora of use cases and conflicting user demands. Next to providing traditional connectivity like its previous generations, 5G also promises to be a heterogeneous network connecting humans, vehicles, unmanned aerial vehicles (UAVs), smart devices, and more. These challenging expectations proved to be overwhelming for traditional network infrastructures to handle. Network slicing has emerged as a promising solution that can achieve such diverse, taxing, and sometimes conflicting requirements in a dynamic and programmable way. There is no denying that UAVs have attained significant focus and research in recent years, and with 5G already being deployed, UAVs can now exploit the capabilities of the new networks. Extensive research is being taken to integrate UAVs into networks, assisting and improving aspects like latency, coverage, and capacity. Motivated by these facts, this survey distinguishes itself from other works by jointly exploring 5G, network slicing, and UAVs. The main contributions of this article are to showcase how UAVs can assist networks, provide a taxonomy of UAVs in the context of network slicing, and survey works that contribute to network slicing with UAVs. In this article, we present a comprehensive survey on UAVs in the context of network slicing, covering contributions, and state‐of‐the‐art literature. We discuss network slicing in‐depth, focusing especially on the three major slices: enhanced Mobile BroadBand, massive machine type communications, and ultra‐reliable low‐latency communications. We provide an overview of 5G enablers, including software‐defined networking and network function virtualization. We cover UAVs and identify their roles in networks as both users and assistants. Furthermore, this survey provides insight into open issues and future research directions related to network slicing and UAVs before concluding.
Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN‐ response pathway activation and senescence in differentiated microglia; an early life stress model
Authors: Wei Jingzhang , Arber Charles , Wray Selina , Hardy John , Piers Thomas M. , Pocock Jennifer M. 
Published: December 2022

AbstractOne form of early life stress, prenatal exposure to glucocorticoids (GCs), confers a higher risk of psychiatric and neurodevelopmental disorders in later life. Increasingly, the importance of microglia in these disorders is recognized. Studies on GCs exposure during microglial development have been limited, and there are few, if any, human studies. We established an in vitro model of ELS by continuous pre‐exposure of human iPS‐microglia to GCs during primitive hematopoiesis (the critical stage of iPS‐microglial differentiation) and then examined how this exposure affected the microglial phenotype as they differentiated and matured to microglia, using RNA‐seq analyses and functional assays. The iPS‐microglia predominantly expressed glucocorticoid receptors over mineralocorticoid receptors, and in particular, the GR‐α splice variant. Chronic GCs exposure during primitive hematopoiesis was able to recapitulate in vivo ELS effects. Thus, pre‐exposure to prolonged GCs resulted in increased type I interferon signaling, the presence of Cyclic GMP‐AMP synthase‐positive (cGAS) micronuclei, cellular senescence and reduced proliferation in the matured iPS‐microglia. The findings from this in vitro ELS model have ramifications for the responses of microglia in the pathogenesis of GC‐ mediated ELS‐associated disorders such as schizophrenia, attention‐deficit hyperactivity disorder and autism spectrum disorder.
LEP and LEPR are possibly a double‐edged sword for wound healing
Authors: Zhang Kai‐Wen , Jia Yuan , Li Yue‐Yue , Guo Dan‐Yang , Li Xiao‐Xiao , Hu Kai , Qian Xiao‐Xi , Chen Zhong‐Hua , Wu Jun‐Jie , Yuan Zheng‐Dong , Yuan Feng‐Lai 
Published: December 2022

AbstractWound healing is a complex and error‐prone process. Wound healing in adults often leads to the formation of scars, a type of fibrotic tissue that lacks skin appendages. Hypertrophic scars and keloids can also form when the wound‐healing process goes wrong. Leptin (Lep) and leptin receptors (LepRs) have recently been shown to affect multiple stages of wound healing. This effect, however, is paradoxical for scarless wound healing. On the one hand, Lep exerts pro‐inflammatory and profibrotic effects; on the other hand, Lep can regulate hair follicle growth. This paper summarises the role of Lep and LepRs on cells in different stages of wound healing, briefly introduces the process of wound healing and Lep and LepRs, and examines the possibility of promoting scarless wound healing through spatiotemporal, systemic, and local regulation of Lep levels and the binding of Lep and LepRs.