bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of Hand-Held Dynamometer Measurement for Thumb Palmar Abduction Strength in Carpal Tunnel Syndrome
Authors: DOI Kazuteru , YASUI Noritada , ISOMURA Yuya , TAGAWA Masafumi , HATTORI Yasunori , SAKAMOTO Sotetsu 
Published: January 2025

Background: In carpal tunnel syndrome (CTS), pain and sensory disturbance are the main symptoms, but thumb palmar abduction (TPA) paralysis cannot be ignored as a concurrent symptom. The reliable quantitative measurement of TPA power was not established. The purpose of this study was to report on the reliability of TPA strength measurements by the hand-held dynamometry (HHD) in large samples of CTS and its superiority over other tests, including grip, pinch powers, TPA angles and manual muscle testing, in terms of clinical progress indicators. Methods: We examined the relative and absolute reliabilities of the perioperative TPA strength measured by HHD (HHD-TPA) in 566 participants with CTS and the correlation coefficient between the HHD-TPA and other clinical tests. Results: The reliability of the HHD-TPA was intraclass correlation coefficients: 97% or higher. The Bland–Altman absolute reliability showed a random pattern of bias, and the minimal detectable changes (MDC) of the inter-rater and intra-rater reliabilities indicated 9.0 N and 7.0 N individually. The HHD-TPA showed statistically significant recoveries between perioperative stages; however, the mean difference larger than the MDC was recognised only between the preoperative and 12-month postoperative stages by intra-rater comparison. More individual patients showed recovery of HHD-TPA beyond the MDC when the same examiner continuously measured HHD-TPA than when multiple examiners continuously measured HHD-TPA. Grip strength and pinch strength measurements showed a strong correlation with HHD-TPA and did not show statistically significant improvement during the perioperative period. Conclusions: HHD-TPA is the most reliable method for quantifying muscle strength in the perioperative course of TPA force in CTS. HHD-TPA is a more reliable assessment of CTS motor recovery when measured consistently for each patient by the same hand therapist. Level of Evidence: Level IV (Diagnostic)
Paediatric Locked Middle Finger due to Synovial Osteochondromatosis: A Case Report
Authors: SONEZAKI Shichoh , OGAWA Hikaru , ODA Yoshinao , KOJIMA Tetsuo 
Published: January 2025

Synovial osteochondromatosis is a relatively rare condition of the hand. We present a rare case of a locked finger in a paediatric patient with synovial osteochondromatosis, in which a tumourous lesion was continuous with the flexor tendon and trapped proximal to the A1 pulley. After resection of the tumour and synovium, no recurrence was observed over a 6-month follow-up period. Synovial osteochondromatosis in the hand or fingers can lead to swelling and limited range of motion; however, symptom progression is usually slow. Moreover, it is uncommon for an extra-articular tumour to cause a sudden onset of locking symptoms without prior warning signs. Comprehensive excision of the synovium is essential, and ongoing observation for recurrence is necessary during follow-up. Level of Evidence: Level V (Therapeutic)
Phase I Study of Adavosertib with Radiotherapy and Temozolomide in Newly Diagnosed Glioblastoma and Intratumoral Drug Levels in Recurrent Glioblastoma
Authors: Lee Eudocia Q. , Alexander Brian M. , Romo Carlos G. , Supko Jeffrey G. , Agar Nathalie Y.R. , Talebi Zahra , Ahluwalia Manmeet S. , Desai Arati S. , Dietrich Jorg , Kaley Thomas J. , Peereboom David M. , Gantchev Jennifer , Baquer Gerard , Santagata Sandro , Takebe Naoko , Desideri Serena , Fisher Joy D. , Sims Megan , Ye Xiaobu , Ligon Keith L. , Nabors Louis B. , Grossman Stuart A. , Wen Patrick Y. 
Published: January 2025

Abstract

Purpose:
Adavosertib is an oral small-molecule inhibitor of Wee1. The Adult Brain Tumor Consortium conducted a phase I study evaluating adavosertib in combination with radiation (RT) and temozolomide (TMZ) in patients with newly diagnosed glioblastoma (GBM), as well as a surgical window-of-opportunity study in recurrent GBM.

Patients and Methods:
The MTD of adavosertib was determined in adult patients with newly diagnosed GBM using a standard 3+3 design in two separate cohorts: with concurrent RT/TMZ or with adjuvant TMZ. A combination cohort with both concurrent and adjuvant adavosertib at MTD followed. We also performed intratumoral drug distribution studies in patients with recurrent GBM undergoing surgery.

Results:
As separate cohorts, the MTD for concurrent adavosertib with RT/TMZ was 200 mg daily Monday through Friday × 6 weeks during RT, and the MTD for adjuvant adavosertib with TMZ was 425 mg daily for 5 days of each 28-day cycle. However, six of 12 patients experienced dose-limiting toxicities (DLT) in the combination cohort. The mean ratios of the intratumoral to plasma concentration of adavosertib were 4.18 ± 3.36 for contrast-enhancing tissue and 0.74 ± 0.63 in nonenhancing tissue.

Conclusions:
Adavosertib at 200 mg daily Monday through Friday × 6 weeks with RT/TMZ and at 425 mg daily on a 5-day/28-day cycle with TMZ had an unacceptable DLT rate. Additional dose levels in combination cohorts resulted in DLT, and we deemed concurrent adavosertib too toxic for further examination. Adavosertib 425 mg daily on a 5-day/28-day cycle with adjuvant TMZ is the recommended phase II dosage. Tissue pharmacokinetics in tissue homogenates and by microdialysis provided complementary information about drug penetration.
Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5
Authors: Běhounek Matěj , Lipcseyová Denisa , Vít Ondřej , Žáček Petr , Talacko Pavel , Husková Zuzana , Kikerlová Soňa , Tykvartová Tereza , Wohlfahrt Peter , Melenovský Vojtěch , Beneš Jan , Petrák Jiří 
Published: January 2025

BACKGROUND:
Right ventricular dysfunction (RVD) is common in patients with heart failure with reduced ejection fraction, and it is associated with poor prognosis. However, no biomarker reflecting RVD is available for routine clinical use.

METHODS:
Proteomic analysis of myocardium from the left ventricle and right ventricle (RV) of patients with heart failure with reduced ejection fraction with (n=10) and without RVD (n=10) who underwent heart transplantation was performed. Concentrations of 2 ECM (extracellular matrix) proteins with the highest myocardial upregulation in RVD, FMOD (fibromodulin) and FBLN5 (fibulin-5), were assayed in the blood and tested in a separate cohort of patients with heart failure with reduced ejection fraction (n=232) to test for the association of the 2 proteins with RV function and long-term outcomes.

RESULTS:

Multivariable linear regression revealed that plasma concentrations of both FMOD and FBLN5 were significantly associated with RV function regardless of the RV function assessment method. No association of FMOD or FBLN5 with left ventricular dysfunction, cardiac index, body mass index, diabetes status, or kidney function was found. Plasma levels of FMOD and FBLN5 were significantly associated with patient outcomes (
P
=0.005;
P
=0.004). Area under the curve analysis showed that the addition of FBLN5 or FMOD to RV function assessment had a significantly higher area under the curve after 4 years of follow-up (0.653 and 0.631, respectively) compared with RV function alone (0.570;
P
<0.05 for both). Similarly, the combination of MAGGIC (Meta-Analysis Global Group in Chronic Heart Failure) score, FBLN5, and FMOD had a significantly larger area under the curve (0.669) than the combination of MAGGIC score+RVD grade (0.572;
P
=0.02). The Kaplan-Meier analysis demonstrated that patients with the elevation of both FMOD and FBLN5 (ie, FMOD >64 ng/mL and FMOD >27 ng/mL) had a worse prognosis than those with the elevation of either FBLN5 or FMOD (
P
=0.03) demonstrating the additive prognostic value of both proteins.

CONCLUSIONS:
Our study proposes that circulating levels of FMOD and FBLN5 may serve as new biomarkers of RVD in patients with heart failure with reduced ejection fraction.
Sound Entities: A Practice in Spatial Composition
Authors: Schnug David 
Published: January 2025

Abstract
This article describes the Sound Entity Creator—a Max abstraction designed for the generation of sound object trajectories for use in electroacoustic spatial composition—and a compositional framework developed for its use. The introductory section addresses issues concerning the use of space in electroacoustic composition and the development of new spatialization technologies. Then the Sound Entity is defined, technical design features of the patches are described, and a compositional framework is presented, which relies on the use of spectral centroid values to generate trajectories typically limited to the surface of a three-dimensional shape. This is followed by examples of the system at work from a composition created by the author. The article concludes with a summary of an expert panel review of the piece that suggests the primary aesthetic goal of the system was achieved.
Learning from Game Live Streaming: A Model for Networked Music Performance
Authors: Peles Goni , Adler Yuval 
Published: January 2025

Abstract
We propose a model of networked music performance to help musicians think through and evaluate their online music productions. First, we utilize a model of game live streaming by T. L. Taylor (2018) to analyze several of our own productions of distanced networked music performances of ludified notation (Peles 2023). Building on Taylor’s model and additional scholarship on music performance, both networked and not, we then extrapolate the insights gained to networked music performance in general and derive a list of key considerations for the analysis, critique, and ideation of networked music performances. Finally, we demonstrate the use of the model through (1) the analysis of a networked music project by other artists, (2) the critique of one of our own recent productions, and (3) the ideation of a potential future performance. Online music production has become an important mode of musicking and continues to grow as a practice. We offer this model as a tool for both practice-based and scholarly work.
Quality Diversity under Sparse Interaction and Sparse Reward: Application to Grasping in Robotics
Authors: Huber Johann , Helenon François , Coninx Miranda , Amar Faïz Ben , Doncieux Stéphane 
Published: January 2025

Abstract
Quality-Diversity (QD) methods are algorithms that aim to generate a set of diverse and highperforming solutions to a given problem. Originally developed for evolutionary robotics, most QD studies are conducted on a limited set of domains'mainly applied to locomotion, where the fitness and the behavior signal are dense. Grasping is a crucial task for manipulation in robotics. Despite the efforts of many research communities, this task is yet to be solved. Grasping cumulates unprecedented challenges in QD literature: it suffers from reward sparsity, behavioral sparsity, and behavior space misalignment. The present work studies how QD can address grasping. Experiments have been conducted on 15 different methods on 10 grasping domains, corresponding to 2 different robot-gripper setups and 5 standard objects. The obtained results show that MAP-Elites variants that select successful solutions in priority outperform all the compared methods on the studied metrics by a large margin. We also found experimental evidence that sparse interaction can lead to deceptive novelty. To our knowledge, the ability to efficiently produce examples of grasping trajectories demonstrated in this work has no precedent in the literature.
Clearing Muddied Waters: The Relationship Between the Rule of Law and the Fight against Corruption in the Jurisprudence of the European Court of Human Rights
Authors: Jelić Ivana , Jungfleisch Julia 
Published: January 2025

Abstract
This paper analyses the nexus between corruption and the rule of law, focusing on the role of international actors in upholding the latter. Special emphasis is placed on asset recovery, including the seizure of property derived from corrupt activities both abroad and within Member States of the Council of Europe and the European Union. The paper focuses on the actions of Member States of the Council of Europe, especially the jurisprudence of the ECtHR and the corresponding international legal framework. The paper concludes with recommendations for fighting corruption while upholding the rule of law for countries in transition and those on their way to European Union accession.
Risk assessment of black soldier fly (Hermetia illucens (L.), Diptera: Stratiomyidae) larvae composting for circular waste management in southern Benin
Authors: Ogbon E.A. , Dzepe D. , Lalander C. , Wiklicky V. , Sinda P.V.K. , Adéoti R. , Mignouna D. , Gbaguidi B. , Behanzin J.G. , Riggi L. , Djouaka R. 
Published: January 2025

Abstract
Insect farming is becoming an important business in West Africa, and the black soldier fly (Hermetia illucens (L.), Diptera: Stratiomyidae) is one of the most widely farmed species. In this study, we investigated the potential risk factors, including heavy metals and pesticides, of the implementation of black soldier fly (BSF)-based technology for circular waste management in the context of Benin. The study was performed in two phases. In Phase 1, we identified and estimated the primary sources of biowaste streams suitable for BSF rearing in Benin. The study involved identifying these sources, estimating their availability, and analysing their characteristics, particularly in terms of contamination levels. In Phase 2, each identified biowaste streams was subjected to BSF larvae treatment and the levels of identified contaminants was analysed before and after the treatment, as well as some microbial contaminants such as Salmonella spp. and Escherichia coli and yeasts and moulds. The majority of biowaste streams and derived BSF larvae were contaminated with copper, chromium, cadmium, lead, and zinc. However, the concentrations detected were below the standard limit values recommended for animal feed. Traces of pesticides were detected in all biowaste streams and derived frass. No pesticide contamination was detected in BSF larvae. Salmonella spp. was found to be the most predominant pathogenic microorganism in fresh BSF larvae as well as in the frass. We therefore recommended to sanitise all BSF larvae that are intended for use in animal feed. As was demonstrated in this study, no Salmonella spp. was found in the sanitised larvae. The findings of this study will promote the establishment of safety measures in the BSF farming sector.
Antipsychotic Drug Prescribing in Children Previously Treated With Stimulants for ADHD: A Population-Based Longitudinal Study: La prescription d'antipsychotiques chez les enfants précédemment traités avec des stimulants pour le TDAH : une étude longitudinale basée sur la population
Authors: Gober Hans J. , Li Kathy H. , Carleton Bruce C. 
Published: January 2025

Objective Stimulant drug treatment in preschool-age children for attention-deficit hyperactivity disorder (ADHD) as well as the concomitant use of antipsychotic drugs is largely unstudied in terms of longitudinal outcomes. We characterized longitudinal patterns of stimulant drug use in children diagnosed for ADHD and analyzed the mental health disorders leading to add-on therapy with antipsychotics. Method The study population comprised of children and adolescents (age: 0–19 years) in the province of British Columbia (BC), Canada, with at least one dispensing for any psychotropic drug between 1997 and 2017 ( N = 144,825). BC health administrative databases were used to identify children with diagnosis for ADHD and dispensings for stimulant and antipsychotic drugs. Longitudinal patterns of drug use and diagnostic codes proximal to the add-on of antipsychotics were assessed. Results We found that residence in rural regions and lack of child psychiatrists are significantly associated with higher rates of stimulant drug prescription in preschool and early school-age children. Residence in rural regions was also associated with a higher rate for the concomitant use of antipsychotics over the course of stimulant treatment. When comparing children starting stimulant therapy before the age of 6 with those starting therapy after 6 years, we found an 82% increase in the likelihood of antipsychotic add-on in those starting stimulants at younger ages (HR: 1.82, 95% CI [1.63–2.04]). Moreover, children starting stimulant therapy before the age of 6 years had 3.57-fold higher rates of diagnostic codes for specific delays in development (ICD-9 315) in close proximity to the antipsychotic add-on. Conclusions The question remains whether the add-on of antipsychotics is a consequence of insufficient action of the stimulant in ADHD, or required to ameliorate the adverse effects of the stimulant drug. Our result suggests that care need to be taken in the diagnosis for ADHD in children at the age when entering elementary school.
Intra-day, short- and long-term reliability of surface electromyographic measurements during a standardized measurement protocol for lower back pain patients
Authors: Domokos Bruno , Hümmer Adrian , Ettinger Julia , Raschka Christoph , Spang Christoph , Düking Peter 
Published: January 2025

Background The identification of back muscle dysfunction is a prerequisite for successful rehabilitation. Therefore, surface electromyography can be used for diagnostic and evaluative purposes. However, data quality highly depends on a) variance and inaccuracies in methodological procedures and b) on time-dependent changes, particularly in complex conditions such as chronic low back pain. Objective To assess intra-day, short-term and long-term reliability of a protocol designed for electromyographic measurements of the paraspinal muscles. Methods Three everyday tasks were selected for measurement in two healthy populations (mean age (years): 26.25/30.49 (SD: 7.05/11.03), sex-balanced). The procedure follows a detailed protocol (e.g., including ultrasound, electrode placement, movement commands). Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and minimum detectable change (MDC) were calculated. Results Prone extension task demonstrated excellent test-retest agreement in all timespans (ICC = 0.92–0.96, SEM = 6.08–8.11, MDC = 16.85–22.49). Forward bending reliability ranged from moderate in long-term (ICC = 0.68–0.71, SEM = 1.98–2.52, MDC = 5.48–6.99) to good in intra-day (ICC = 0.76–0.89, SEM = 1.73–2.15, MDC = 4.79–5.95) to excellent in short-term assessment (ICC = 0.97, SEM = 1.07–1.21, MDC = 2.96–3.34). Sitting task showed the lowest test-retest agreement ranging between good to moderate in intra-day (ICC = 0.60–0.77, SEM = 1.22–1.26, MDC = 1.61–3.48)) and short-term reliability (ICC = 0.50–0.75, SEM = 1.24–2.06, MDC = 0.62–4.04) and moderate in long-term reliability (ICC = 0.65–0.71, SEM = 1.43–1.85, MDC = 3.95–5.12). Conclusion Using standardized procedures, surface electromyography can provide reliable data for practitioners in low back pain rehabilitation. Timespan had a limited influence on reliability compared to the type of task performed.
Efficacy Analysis of Hypofractionated Radiotherapy for Oligometastatic Tumors: A Retrospective Study
Authors: Sun Qian , Zhao Hanqing , Zhang Xianwen , Zhang Suli , He Zelai , Wang Gengming , Jiang Hao , Xuan Aili , Li Xianming 
Published: January 2025

Introduction Metastasis remains a major cause of death among patients with malignant tumors. Radiotherapy is one of the main modalities of cancer treatment. The rapid development of radiotherapy technology has enabled the widespread application of hypofractionated radiotherapy (HFRT) in clinical practice. This study aimed to evaluate the effect of HFRT on the survival and safety of patients with oligometastatic tumors. Methods We conducted a retrospective study that involved 65 patients with well-controlled primary tumors and 1–5 metastatic foci treated at the study site between January 2020 and December 2022. Patients were aged >18 years and had a ≥ 6-month life expectancy. The patients received standard treatments plus HFRT for all metastatic foci. The dose fractionation regimen was adjusted according to the location and size of the patient’s metastatic foci. The planning gross tumor volume of HFRT was 82.93 cm3 (range: 10.12-562.80 cm3), and the radiation dose range was 20 Gy/5 F–60 Gy/15 F. Progression-free survival (PFS), overall survival (OS), local control rates, and incidence of adverse events of the patients were observed. Results Among the 65 patients, the median follow-up time, PFS, and OS were 26 months (95% CI: 0.80-37.50), 15 months (95% CI: 9.36-20.64), and 28 months (95% CI: 16.71-39.29), respectively. The 1- and 2-year PFS were 53.8% and 40.0%, respectively, while the 1- and 2-year OS rates were 73.8% and 56.9%, respectively. In total, 13.8%, 55.4%, 20.0%, and 13.8% of patients showed complete response, partial response, stable disease, and progressive disease, respectively. Four patients developed grade 3 or worse adverse events, and no treatment-related deaths occurred. Conclusions HFRT showed favorable clinical efficacy and safety in patients with oligometastatic tumors, generally achieving a good OS rate. Further randomized trials should be conducted.
Chatbot-delivered mental health support: Attitudes and utilization in a sample of U.S. college students
Authors: Rackoff Gavin N. , Zhang Zhenyu Z. , Newman Michelle G. 
Published: January 2025

Objective Chatbots’ rapid advancements raise the possibility that they can be used to deliver mental health support. However, public utilization of and opinions toward chatbots for mental health support are poorly understood. Methods Survey study of 428 U.S. university students who participated in early 2024, just over one year after the release of ChatGPT. Descriptive analyses examined utilization of and attitudes toward both traditional mental health services (i.e. psychotherapy, counseling, or medication) and chatbot-delivered mental health support. Results Nearly half (49%) of participants reported having used a chatbot for any purpose, yet only 5% reported seeking mental health support from a chatbot (8% when only considering participants with probable depression or generalized anxiety disorder). Attitudes toward traditional mental health services were broadly positive, and attitudes toward chatbot-delivered support were neutral and significantly less positive ( d = 1.18, p < .001). Participants reported lack of need and doubts about helpfulness as barriers to using chatbot-delivered support more frequently than they reported them as barriers to traditional services. Cost, time, and stigma barriers were less frequently reported for chatbot-delivered support than for traditional services. Attitudes were generally consistent as a function of mental health status. Conclusion Among U.S. students, utilization of chatbots for mental health support is uncommon. Chatbots are perceived as less likely to be beneficial, yet also less affected by cost, time, and stigma barriers than traditional services. Rigorous outcome research may increase public trust in and utilization of chatbots for mental health support.