bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemotherapy alone versus chemotherapy plus 125I brachytherapy for the second-line treatment of locally recurrent cervical cancer after/with radical treatment: a propensity score analysis
Authors: Huang Zhimei , Yao Wang , Zhong Zhihui , Yang Guang , Liu Jihong , Gu Haifeng , Huang Jinhua 
Published: May 2023

Abstract
Objectives To retrospectively compare the survival between chemotherapy alone and the combination of chemotherapy and 125I brachytherapy for recurrent cervical cancer (CC) after radical treatment with failure from first-line chemotherapy.Methods Patients with recurrent CC after radical treatment with failure from first-line chemotherapy were collected between January 2007 and December 2016 from the two medical centers, and allocated into 2 groups. Group A underwent second-line chemotherapy alone and Group B received the combination of second-line chemotherapy and 125I brachytherapy. The overall survival (OS) as well as progression free survival (PFS) were evaluated. Propensity score matching (1:1), Kaplan-Meier curves, log-rank test, along with cox proportional hazards regression were performed for survival analysis.Results A matched cohort with Group A (n = 88) and Group B (n = 88) were included. The 1-, 2-, and 3-year cumulative PFS rates were 40.9%, 15.9%, 5.7% in Group A and 79.5%, 48.9%, 25.0% in Group B, respectively; and the difference was significant between groups (P = 0.003). Besides, the 1-, 2-, and 3-year cumulative OS rates were 67.0%, 27.3%, 5.7% in Group A and 89.8%, 63.6%, 30.7% in Group B, respectively, with significant difference between groups (P < 0.001). Additionally, the incidence of complications was similar between groups (P = 0.698).Conclusions The combination of chemotherapy and 125I brachytherapy has better therapeutic effect but similar rates of complications compared to chemotherapy alone in patients with locally recurrent CC after radical treatment with failure from first-line chemotherapy.
"It is human work": qualitatively exploring community roles that facilitate cultural food security for people from refugee backgrounds
Authors: Gingell Tina , Adhikari Rishita , Eltahir Nehal , Ntahomvukiye Fulgence , Pe Evelyn , Murray Kate , Correa-Velez Ignacio , Gallegos Danielle 
Published: May 2023

Abstract
Background Cultural food security is crucial for cultural health and, for people from refugee backgrounds, to assist with the settlement journey. Upon arrival in a new environment, people seek to form new relationships to create a sense of belonging, and food is often used as a pathway to achieve these connections. When displaced communities can act autonomously, new foodways may be formed to sustain cultural food security, and as a result, communities flourish. However, there is a lack of understanding about how refugee-background communities sustain cultural food security in the Australian context. This study aimed to explore key roles in refugee-background communities to understand why they were important and how they facilitate cultural food security.Methods Community researchers conducted interviews with people who came from a refugee-background community, lived in Greater Brisbane, and who fulfilled a key food role in the community that facilitated access to cultural foods. Participants were interviewed in the language and location they preferred. Data were collected on the participant’s role and activities supporting cultural food security. Transcripts were collectively analysed using a best-practice framework for collaborative data analysis.Results Six interviews were conducted between August and December 2022. Participants filled crucial and unique roles facilitating access to cultural foods for communities in Greater Brisbane. Cultural food security supported settlement by creating connections across geographical locations and cultures, and generated a sense of belonging that supported the settlement journey. Communities utilised communication methods that prioritised the knowledge, wisdom and experience of community members. This communication method allowed community members to influence the decisions of community retailers to increase the supply of cultural foods. Community leaders had an ethos that reflected collectivist values, where the needs of the community were an important part of their own health and wellbeing.Conclusions Communities are inherently structured and communicate in a way which allows collective agency over foodways supporting cultural food security. This collective agency is suggestive of food sovereignty where food justice and access are prioritised. Researchers and public health workers should work with communities and recognise community expertise and agency over foodways. Food security interventions should target cultural food security and autonomy.
The F-box protein encoding genes of the leaf-rust fungi Puccinia triticina: Genome-wide identification, characterization and expression dynamics during pathogenesis
Authors: Gidhi Anupama , Jha Shailendra Kumar , Kumar Manish , Mukhopadhyay Kunal 
Published: May 2023

Abstract

Aim - This study was aimed at identifying F-box genes in Puccinia triticina, the causal organism for the leaf rust disease in wheat and inferring their role in pathogenicity in susceptible wheat plants.
Methods and results - Genome-wide analysis revealed 10 F-box genes and were characterized using in silico approaches for revealing phylogenetic relationships, gene structures, gene ontology, protein properties, sequence analysis and gene expression studies. Domain analysis predicted functional domains like WD40 and LRR at C-terminus along with the obvious presence of F-box motif in N-terminal. MSA showed amino acid replacements, which might be due to nucleotide substitution during replication. Phylogenetic analysis revealed the F-box proteins with similar domains to be clustered together while some were spread out in different clades, might be due to functional diversity. The clustering of GG705409 and TaAFB4/TaAFB5 in a single clade suggested the possibilities of horizontal gene transfer during the coevolution between Pucciniaand wheat. Gene ontological annotation categorized them into three classes and were functionally involved in protein degradation through the protein ubiquitination pathway. Protein-protein interaction network revealed F-box proteins to interact with other components of SCF complex involved in protein ubiquitination. Relative expression analysis of five F-box genes in a time course experiment denoted their role in pathogenicity in leaf rust susceptible wheat plants.
Conclusion- This study provides information on structure elucidation of F-box proteins of a basidiomycetes plant pathogenic fungi and their role during pathogenesis. A total of 10 F-box genes were predicted in Puccinia triticina genome sequences that revealed conserved phylogenetic relationship among different Pucciniaspecies. Expression analysis imparted their role in pathogenicity.
A study of the inter- and intra-operator variability on echocardiographic measurements in dogs
Authors: Ghilardi Sara , Pradelli Danitza , Rizzi Rita M. , Polli Michele , Bagardi Mara , Santilli Roberto A. , Brambilla Paola G. , Bussadori Claudio M. 
Published: May 2023

Abstract
Standard transthoracic echocardiography is considered the non-invasive gold standard for the diagnosis of most cardiac diseases. Defining reproducibility, repeatability, and reliability of this exam is imperative to reduce errors in clinical evaluations. The present study aimed at: 1) evaluating the reproducibility and repeatability of 15 echocardiographic parameters in dogs by analyzing measurements obtained from several operators with different levels of experience and comparing them to the ones obtained from two board-certified operators (gold standards - GSs); 2) assessing whether different formative paths have an influence on the variability of the echocardiographic measurements. Fifty-one operators have been included in this study, along with two diplomates of the European College of Veterinary Internal Medicine - Cardiology. Ten dogs were enrolled, 5 Golden Retrievers and 5 Cavalier King Charles Spaniels. Echocardiographic examination was performed on each dog by one GS and several operators on the same day. Results show that M-mode measurements of the interventricular septum and the left ventricular free wall are the least reliable ones since they show a high deviation from the GS and a poor inter-operator reproducibility. Differently, M-mode-obtained internal diameters of the left ventricle in systole and diastole, and measurements of the aortic annulus and root are the most reliable echocardiographic parameters, demonstrating that all the operators can correctly assess left ventricular systolic function and dilation, and evaluate the aortic valve. Furthermore, a specialist clinical activity, more than the acquired theoretical knowledge, affects the reliability of the echocardiographic examination by reducing the difference from the GS’ measurements.
The mechanism of Pb(II) and Cd(II) removal by coffee grounds biochar: Role of KOH modification
Authors: Deng Zhihua , Ma Peiyao , Xiang Ping 
Published: May 2023

Abstract
In order to make comprehensive use of coffee grounds, and to investigate the effect of KOH on the surface properties of biochar and the adsorption performance of heavy metal Pb(II) and Cd(II), this paper investigates the surface properties and the adsorption performance of unmodified and modified biochar for heavy metal Pb and Cd ions by means of SEM, elemental analysis, FTIR, XRD and other characterization, adsorption kinetics, adsorption thermodynamic model fitting, and other adsorption experiments. The results show that the modified biochar has the best adsorption performance for heavy metals, the maximum adsorption capacity for Pb(II)and Cd(II) reaches 593 mg/g and 128 mg/g respectively, and the adsorption process is mainly chemical adsorption. An isothermal sorption fit using the Langmuir and Freundlich model can better reflect the sorption behaviour and properties of biochar in coffee grounds. The results show that KOH modification has a good activation on biochar, and KOH- activated biochar from coffee grounds has excellent adsorption performance on Pb(II) and Cd(II).
Are The Seizures Under Control or Unnoticed? Electroclinical Evaluation of Epilepsy with Eyelid Myoclonia
Authors: Yasguclukal Miray Atacan , Gulec Bade , Elmali Ayse Deniz , Yalcinkaya Cengiz , Demirbilek Veysi 
Published: May 2023

Abstract

Purpose In this study, patients with epilepsy with eyelid myoclonia (E-EM) were evaluated according to their EEG findings, seizure outcomes, and their consistency with the final ictal EEG findings. We also investigated the possible prognostic factors.Methods Patients with E-EM and at least two years of follow-up in our clinic were included in the study. We analyzed the presence of eyelid myoclonia, absence and myoclonic seizure, and generalized tonic-clonic seizure for the prior two years and then verified with the latest ictal EEG features. Video-EEGs were analyzed according to the background activity, the existence of generalized spike-wave discharge or polyspike-wave complexes, focal spike-wave discharge, photoparoxysmal responses, and fast activity.Results Twenty-one patients were involved in this study. In six patients, the seizures were undetected on the first EEGs, whereas they were detected on subsequent ones. The seizures were captured on the first EEGs of six patients; however, they disappeared on subsequent ones. Only one patient had seizures detected on every EEG. The consistency of the seizures was variable in eight patients. At final follow-up, seizures were reported as under control for more than two years in 12 patients, according to patients and their parents’ report. However, ictal EEG findings were detected in six of these patients. No electroclinical feature was associated with seizure freedom.Conclusion This study provides further evidence that the prognosis of E-EM is complicated and probably poor. The patients and their parents may not be aware of the seizures. Therefore, video-EEG monitorization is essential during follow-up.
Real-time Co-PPGIS Based Integrated Grievance Redressal Management System Modeling of Public Water Utilities of Lahore
Authors: Mehmood Rashid , Mahmood Syed Muhammad Amer , Butt Muhammad Atif 
Published: May 2023

Abstract
Lahore is the most populated and a rapid growing city of the province Punjab, Pakistan. The need of the time is to bank on e-governess to meet the demands of the people. To satisfy the complaint and grievance linked to the city emergency services, water supply and sanitation. Currently, these services are being handled by each department themselves and no proper centralized grievance system exists. There is no integrated approach adopted in response to complaints in Water and Sanitation Agency (WASA), established by Lahore Development Authority (LDA). GPS mobile phones have become equally common in urban and rural areas. This paper will introduce an innovated technology based system name GIS-based real-time Grievance Redressal management system which is initially designed for Lahore. This system employs the Collaborative Public Participatory GIS (Co-PPGIS) environment for visualizing and analyzing the real-time Geo-statistical data both in spatial and non-spatial view through mobile and web based applications. The customer will register their complaint through android and web based applications equipped with map and participatory tools provided by the GIS. This paper provides a structure to overcome the mismanagement issues in government agencies and devises a check and balance flow model primarily for public utilities like water supply, sanitation and sewage. Hence, this paper is an effort to resolve public issues and grievance real-time engagement in faster, accurate and trustworthy way.
Dynamics in a memristor-coupled heterogeneous neuron network under electromagnetic radiation
Authors: Peng Cheng , Li Zhijun , Wang Mengjiao , Ma Minglin 
Published: May 2023

AbstractThe electromagnetic environment around neurons is very complex, and studying the effect of electromagnetic radiation on the firing behavior of neurons is of great significance. In this paper, we establish a memristor coupled heterogeneous neuron network composed of a HR neuron and a FHN neuron, where the effect of electromagnetic radiation is modeled by the induced current of the flux-controlled memristor. The firing behaviors of the network are studied through phase diagrams, time series, bifurcation diagrams, Lyapunov exponent spectrums, and local attraction basins. It is found that under different initial conditions, the network exhibits different bifurcation routes by varying the coupling strength, resulting in the coexistence of multiple firing patterns. More interestingly, the network, under different initials, appears completely opposite bifurcation routes when the electromagnetic radiation intensity varies. In addition, synchronous firing behavior between two heterogeneous neurons is also explored. It is observed that both neurons can achieve phase synchronization when the coupling strength decreases to a negative value. Finally, the numerical analysis is verified by the Multisim circuit.
Host’s body mass, not sex, affects ectoparasite loads in yellow-necked mouse Apodemus flavicollis
Authors: Zduniak Milena , Serafini Sarah , Wróbel Aleksandra , Zwolak Rafał 
Published: May 2023

AbstractWe investigated the presence and potential causes of sex bias in ectoparasite infestations in the yellow-necked mouseApodemus flavicollis. We compared the natural tick and flea burdens of male and female mice in a temperate beech forest and assessed whether the observed differences were driven by host sex or body mass. We found that males were more heavily infested by ticks compared to female mice. However, this difference was driven by host body mass, and not sex itself. Host body mass positively correlated with flea loads, but there was no evidence of sex bias in flea abundance. In addition, the abundance of both ticks and fleas infesting yellow-necked mice changed over time, both seasonally (month to month) and annually (year to year). Our results underscore the importance of the sexual size dimorphism and the parasite taxon as the primary factors that influence the occurrence of sex-biased parasitism in small mammals.
Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans models
Authors: Chen Yun , Xu Ruina , Liu Qiaoxing , Zeng Yanting , Chen Weitian , Liu Yongfa , Cao Yong , Liu Guo , Chen Yunjiao 
Published: May 2023

Abstract

Numerous natural antioxidants have been developed into agents for neurodegenerative diseases (NDs) treatment. Rosmarinic acid (RA), an excellent antioxidant, exhibits neuroprotective activity, but its anti-NDs efficacy still reminds puzzled. Here, Caenorhabditis elegans models were employed to systematically reveal RA-mediated mechanisms in delaying NDs from diverse facets, including oxidative stress, the homeostasis of neural and protein, and mitochondrial disorders. Firstly, RA significantly inhibited reactive oxygen species accumulation, reduced peroxide malonaldehyde production, and strengthened the antioxidant defense system via increasing superoxide dismutase activity. Besides, RA activated Notch and Wnt signaling to promote neurohomeostasis, reduce neuronal loss, and ameliorated polyglutamine and ɑ-synuclein-mediated dyskinesia in NDs models. Further, RA enhanced proteostasis by activating insulin/insulin-like growth factor 1 signaling, mitogen activated protein kinases and heat-shock factor 1 pathways. More importantly, molecular docking results revealed that RA specifically bound huntington protein and ɑ-synuclein to prevent toxic protein aggregation, which was consistent with the data that RA diminished polyglutamine and ɑ-synuclein aggregates in nematodes. Finally, RA ameliorated mitochondrial dysfunction including increasing adenosine triphosphate and mitochondrial membrane potential levels and rescuing mitochondrial membrane proteins’ expressions and mitochondrial structural abnormalities via regulating mitochondrial dynamics genes and improving the mitochondrial kinetic homeostasis. Thus, this study systematically revealed the RA-mediated neuroprotective mechanism and promoted RA as a promising nutritional intervention strategy to prevent NDs.
Intelligent recommendation system of injection molding process parameters based on CAE simulation, process window and machine learning
Authors: Ma Yitao , Dang Kaifang , Wang Xinming , Zhou Yang , Yang Weimin , Xie Pengcheng 
Published: May 2023

AbstractIn this research, a recommendation system was designed for optimizing the injection molding process parameters. The system incorporates the utilization of process windows, XGBoost, and genetic algorithms. CAE simulations were conducted to generate process window data and simulation data. Automatic hyperparameter optimization of the XGBoost was performed using grid search and cross-validation methods. The system employs 5 injection molding feature parameters as input and one product feature as output, and SEGA was used for predicting the optimal injection molding process parameters. The performance of the prediction model was evaluated using an RMSE of 0.0202 and an R2of 0.9826. The accuracy of the system was verified by conducting real production. The deviation of the product weight obtained from real production from the desired weight is 0.22%, which means that the prediction model achieves a correct rate of 99.78%. This recommendation system has a significant application value in reducing production costs and cycle time, as it can provide initial injection process parameter suggestions solely through the mold's digital data.
Applying the COM-B behavior model to inform the delivery of spatial repellents and insecticide-treated clothing among forest exposed populations in Mondulkiri Province, Cambodia
Authors: Chen Ingrid , Doum Dyna , Mannion Kylie , Hustedt John , Sovannaroth Siv , McIver David , Macdonald Michael , Lobo Neil F , Tatarsky Allison , Handley Margaret , Neukom Josselyn 
Published: May 2023

Abstract
Background: Southeast Asia is making tremendous progress towards their 2030 malaria elimination goal but needs new interventions to stop forest malaria. This study trials two new vector control tools, a volatile pyrethroid spatial repellent (VSPR) and insecticide-treated clothing (ITC), amongst forest-exposed populations in Mondulkiri Province Cambodia to inform their potential use for eliminating forest malaria.
Methods: 21 forest-exposed individuals were given a questionnaire on their perceptions of malaria and preventive practices used, after which they trialed two products sequentially. Mixed methods were used to understand their experience, attitudes, and preferences regarding the products trialed. Quantitative data was summarized and qualitative insights were analyzed using thematic analysis, applying the Capability, Opportunity, Motivation Behavior Change (COM-B) model and Behavior Change Wheel Framework to identify intervention functions to support tailored product rollout amongst these populations.
Results: Study participants reported a need for protection from mosquito bites in outdoor and forest-exposed settings and perceived both products trialed to be effective for this purpose. The VPSR product was preferred when travel was not required, whereas ITC was preferred for ease of use when going to the forest, especially in rainy conditions. COM-B analysis identified that key enablers for use of both products included their perceived efficacy and ease of use, which required no skill or preparation. For barriers to use, the odor of ITC was sometimes perceived as being toxic, as well as its inability to protect uncovered skin from mosquito bites, while the perceived usefulness of the VPSR product trialed was limited by its water sensitivity in rainy forest settings. Intervention components to encourage appropriate and sustained use of these products include education about how to use these products and what to expect, persuasion to use them from community leaders and targeted ads, and enablement to guarantee access.
Conclusion: The rollout of VPSRs and ITC amongst forest-exposed populations can be useful for eliminating malaria in Southeast Asia. Study findings can be applied to increase product uptake in Cambodia, while research efforts can aim to develop products that are rainproof, easy to use in forest settings, and have favorable odor profiles to target users.
Dotinurad restores exacerbated kidney dysfunction in hyperuricemic patients with chronic kidney disease
Authors: Amano Hoichi , Kobayashi Seiji , Terawaki Hiroyuki 
Published: May 2023

Abstract
Background In this study, we aimed to clarify the beneficial effects of urate-lowering treatment with the novel agent dotinurad on renal function in patients with chronic kidney disease (CKD) and hyperuricemia (HUA).Methods Thirty-five patients with CKD (mean age 65.4 ± 14.8 years, 23 men) diagnosed with HUA were recruited. Changes in eGFR before and after dotinurad administration were assessed.Results During the 3-month observation period, mean eGFR (mL/min/1.73 m2) declined significantly from 35.5 ± 16.8 to 31.8 ± 16.4, whereas it recovered to 36.5 ± 17.5 after dotinurad administration. The increase in eGFR after dotinurad administration was correlated with a decrease in sUA (R = 0.375, p = 0.0263).Conclusion Dotinurad administration to patients with CKD and HUA appears to be beneficial in restoring kidney function. Dotinurad may represent a potential medication for the prevention of kidney function decline caused by HUA.