bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of a differential approach to surgical treatment of proximal humerus fractures in patients with osteoporosis
Authors: Korzh Mykola , Makarov Vasyl , Gupalov Igor , Pertseva Olena , Boyko Konstantin , Pidgaiska Olga 
Published: June 2023

Objective. To conduct a comparative retrospective analysis of the anatomical and functional results of surgical treatment of proximal humerus fractures AO/OTA 11-B, 11-C using different methods in patients over 50 years old with osteoporosis to justify a differential approach. Methods. The study included 102 patients aged 50 years and older with osteoporosis and proximal humerus fractures AO/OTA 11-B, 11-C. The patients were divided into three groups: I — 50 (16 men, 34 women) whom were performed open reduction and internal fixation (ORIF) with the PHILOS plate; II — 44 (8 men, 36 women) — ORIF with the PHILOS plate and using 3D polylactide (PLA) porous implants were applied; III — 8 (2 men, 6 women) whom were performed primary reversed total shoulder arthroplasty (RTSA) with developed total reversible endoprosthesis. The results of treatment were evaluated according to the Constant-Murley Shoulder Score system after 3, 6, 12 months. The results. Positive results in the first group were obtained in 72.0 % of patients (the average Constant-Murley Shoulder Score after 12 months was 78.4 points); in the second — in 81.8 % (88.0 points); in the third — 75.0 % (82.0 points). A differentiated approach to the choice of surgical treatment of patients aged 50 years and older with fractures AO/OTA 11-B, 11-C is proposed. The clinical trial of the reverse total modular shoulder endoprosthesis developed by us using porous 3D titanium parts, manufactured by additive technologies, showed positive short-term results. The design features of the device increase the reliability and durability of proposed endoprosthesis. Conclusions. RTSA in the case of unstable proximal humerus fracture or in the case of metal structure migration after primary ORIF in patients with low bone mineral density is the effective surgical intervention that allows to achieve satisfactory functional results in up to 3 years.
The knee joint deformities in rheumatoid arthritis patients
Authors: Herasymenko Sergiy , Poluliakh Myhailo , Babko Andriy , Herasymenko Andriy , Рoluliakh Dmytro , Kachan Dmytro , Kostogryz Yuriy , Duda Maksym , Huzhevskyi Igor 
Published: June 2023

Knee joints injury in rheumatoid arthritis patients appear in 70 % cases. This is the most common cause of loss of work capacity, the ability to self-care. Patients become severely disabled, in that the disease is accompanied by deformations with the development of discordant positions of the lower limbs, which lead to a partial or complete loss of the function of support and walking, so this problem needs to be studied. Objective. To make an analysis of orthopedic treatment of secondary arthrosis of knee joints in RA patients, complicated by deformities depending on the age and gender of the patient, stage, duration of the disease and activity of the inflammatory process. Methods. In this work we have analyzed the orthopedic treatment of 66 RA patients with secondary arthrosis with axial deformities, who underwent 75 total endoprosthetics between 2013 and 2020. Anamnestic data, clinical, biomechanical and statistical research methods were used. The obtained data were evaluated using the scale of Joseph J., Kaufman E. E. Results. The analysis of the results of knee joint replacement was followed in the period from 6 months to 5 years. The results were carried out according to the 100-point scale Joseph J., Kaufman E. E. (1990). Thus, the analysis of the results of total knee arthroplasty in patients with RA according to the scale of Joseph J., Kaufman E. E. showed that good results were obtained in 46 (79.31 %) patients, satisfactory results in 11 (18.97 %) and unsatisfactory results obtained in 1 (1.72 %) patients. The reliable relationship of the level of joint deformation with the level of disease activity and with the scale of Joseph J., Kaufman E. E. was researched. Other indicators are not reliably correlated with the level of joint deformation. As a result of pairwise comparisons of groups with each other using the Duncan test, a significant increase in the degree of joint deformation was found in the group with activity 3 compared to the group with activity 1. The use of basic or complex therapy does not reliably affect the degree of joint deformation. Conclusions. Total knee joint replacement need patients with II stage of the 2nd phase of the disease and higher. In our opinion, this is the most optimal time for surgical treatment, which allows patients with RA to fully use the possibilities of an implanted endoprosthesis.
Mathematical modeling of the acetabulum fracture (type 62-B1.3 by AO/ASIF) deformities and hip endoprosthetics in combination with osteosynthesis
Authors: Vyrva Oleg , Vatamanitsa Dmytro , Karpinsky Mykhaylo , Yaresko Oleksandr 
Published: June 2023

Secondary degenerative disabling changes in the hip joint often develop in the long term after surgical treatment of hip fractures. A well-founded differential approach to the selection of endoprosthesis components and additional means of stabilizing bone fragments is necessary. Objective. To investigate changes in relative deformation values in a hip joint model with a acetabulum fractures 62–B1.3 type by AO/ASIF classification under the conditions of its endoprosthesis using various osteosynthesis options. Methods. A basic finite-element model of the pelvic girdle of a person with a fracture of the bottom of the cruciate ligament type 62-B1.3 (АО/ASIF) was developed, on which 7 variants of endoprosthesis of the left hip joint were modeled: without fracture (1); without osteosynthesis of fragments (2); fixation of a fragment of the acetabulum back wall with two screws (3), two screws and a bone plate (4), two screws and a bone plate with a Jumbo cup implantation (5); 5 case, long screw in the front column (6); option 5, long screws in the front and rear columns (7). Results. When using a large-sized Jumbo cup, the relative deformations of the bone regenerate in the center of the bottom of the KZ were reduced to 1.0 %, regardless of the osteosynthesis option. Around the free fragment of the short circuit, the largest relative deformations (3.0 %) were found in version 5 of the model. The use of long rods in the columns led to decrease in the relative deformations of the bone regenerate around the free fragment of the KZ to 2.0 %. Conclusions. Mathematical models proved that an increase in the number of osteosynthesis tools under the conditions of the total hip endoprosthesis replacement, 62-B1.3 (АО/ASIF) type KZ fracture leads to a decrease in the relative deformations of the bone regenerate along the entire fracture line. The use of a large-sized Jumbo cup makes it possible to reduce the level of relative deformations of the bone regenerate in the cent­ral part of the KZ.
The effectiveness of resistance to torsional loads of various options for osteosynthesis of bone fragments of the tibia for fractures in the upper third of the diaphysis (mathematical modeling)
Authors: Karpinsky Mykhaylo , Stroiev Maksym , Berezka Mykola , Hryhoruk Viktoriia , Yaresko Oleksandr 
Published: June 2023

The treatment of patients with tibial fractures and overweight has certain peculiarities due to the increased load on the osteosynthesis device. Objective. To compare the stress-strain state of models of the lower leg with a fracture of the tibia in the upper third of the diaphysis under the influence of torsional load under different options of osteosynthesis depending on the patient's weight. Methods. Using the finite element method, a fracture in the upper third of the tibia and three types of osteosynthesis were modeled: using an external fixation device (EFD), a bone plate, and an intramedullary rod. A torque of 7 Nm and 12 Nm was applied to the tibial plateau. The results. The highest indicators of the stress level in the fracture zone (6.3‒10.8 MPa) and on the metal structure (251.0‒430.2 MPa) were determined in the model with a bony plate. In the model with osteosynthesis with the help of EFD, a fairly low stress level (0.2‒0.3 MPa) was established in the fracture zone, but a high one in the proximal part of the tibia (6.7‒11.5 MPa). The lowest values of stresses in the fracture zone (0.1‒0.2 MPa) and the proximal fragment of the tibia (0.6‒1.0 MPa) were determined under the conditions of reproduction of osteosynthesis using an intramedullary rod, but in the distal part of the tibia the stresses remained quite high — 11.1‒19.0 MPa. Conclusions. The values of stresses in the fracture zone in the models with EFD and intramedullary rod were significantly lower than the values of the intact bone, with the periosteal plate - only at a load of 7 Nm. In the distal fragment of the tibia, the highest stress level was determined in the model with osteosynthesis with an intramedullary rod, in the proximal one — with EFD. Among the metal structures, the greatest stresses were found in the periosteal plate and around the fixing screws and rods under the conditions of its use. The function of the dependence of the amount of stress on the weight of the patient in the elements of the model turned out to be linear and directly proportional.
Analysis of the relationship between degenerative changes in the joint under conditions of hip osteoarthritis with hemostasis disorders in patients based on the results of a biochemical study
Authors: Bondarenko Stanislav , Filipenko Volodymyr , Morozenko Dmytro , Leontyeva Frieda , Vysotskyi Oleksandr , Maltseva Valentyna 
Published: June 2023

Venous thromboembolism is one of the serious complications that occurs after total hip arthroplasty (THA). Among the risk factors may be the presence of disorders of hemostasis and fibrinolysis in patients before surgical intervention. The aim of study to identify the influence of hip osteoarthritis III–IV stages on the hemostasis of patients before performing THA. Methods. A prospective study was conducted with the participation of 60 patients with hip ostheoarthritis III–IV stages and 30 healthy volunteers (control group). Blood and urine samples were obtained from all participants (in patients — one day before THA). Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, fibrinolytic activity (FA), soluble fibrin monomer complexes (SFMCs), glycoproteins, sialic acids, chondroitin sulfates (CS), acid and alkaline phosphatases, β lipoproteins were determined in the blood; in urine — oxyproline, uronic acids, Ca and P. The Pearson correlation coefficient (r) was calculated to determine the relationship between markers of hemostasis and connective tissue metabolism. Results. Compared with the control group, the level of alkaline phosphatase in the blood of patients with hip ostheoarthritis level of glycoproteins (r = 0.97; p < 0.05), cholesterol (r = 0.91; p < 0.05); the level of SFMCs was correlated with the level of glycoproteins (r = 0.99; p < 0.05), CS (r = 0.94; p < 0.05). Conclusions. In patients with hip ostheoarthritis III-IV stages the levels of connective tissue markers (glycoproteins, CS) correlate with the levels of hemostasis markers (fibrinogen, SFMCs). This is of clinical significance for the timely prevention of the development of thromboembolic complications in patients to whom THA is recommended.
EFFECT OF RAMELTEON ON LIPOPOLYSACCHARIDE INDUCED HIPPOCAMPAL TOXICITY
Authors: KAYNAK Mine , SAVRAN Mehtap , AŞÇI Halil , GÜLLE Kanat , İLHAN İlter 
Published: June 2023

Objective
Despite the advances in medicine, sepsis still remains
a major health problem worldwide and brain tissue is
one of the structures damaged in the early period of
sepsis. Neuroinflammation (NI) is considered as the
main mechanism in septic brain injury. Ramelteon
(RML) is a non-selective (MT1 / MT2) melatonin
receptor agonist and was approved by the FDA in 2005
with the indication of insomnia. RML shows relatively
higher affinity for both receptor subtypes among other
melatonergic agonist drugs.
Material and Method
Twenty-eight male Wistar Albino rats were used
to investigate the protective effect of RML on
lipopolysaccharide (LPS) induced NI. Control, LPS (5
mg/kg, intraperitoneally), RML (8 mg/kg, orally) and
LPS + RML (45 minutes before LPS) groups were
created. Six hours following the last drug administration,
rats were sacrificed. Blood for hemogram analysis and
cortical and hippocampal tissues for histopathological
evaluation were collected.
Results
LPS increased white blood cell and neutrophil/
lymphocyte ratio (NLR) while it decreased lymphocyte
and platelet counts. RML decreased NLR and
increased platelet counts significantly. In histochemical
evaluation, marked inflammatory cell infiltration and
apoptosis were observed in both hippocampal and
cortical areas of LPS group. RML decreased the
inflammatory response and apoptotic bodies in these
areas.
Conclusion
RML may be protective on LPS-induced NI observed in
hippocampus via anti-inflammatory and anti-apoptotic
mechanisms.
ANKAFERD BLOOD STOPPER ALLEVIATES CADMIUM-INDUCED LUNG INJURY BY REDUCING MITOCHONDRIAL STRESS-RELATED APOPTOSIS VIA BAX/BCL-2 AND CYT-C/CAS-3 PATHWAYS
Authors: TEPEBAŞI Muhammet Yusuf , SEZGİNER Perihan 
Published: June 2023

As a result of environmental factors, cadmium (Cd)
taken into the body causes damage to lung tissues
through inflammation, oxidative stress, and increased
apoptosis. Ankaferd Blood Stopper (ABS), which is
used as a hemostatic agent, has antioxidant, antiinflammatory,
antibacterial, antiapoptotic, and wound
healing properties due to five different plant extracts
and components in its composition. Therefore, in our
study, we aimed to investigate the curative effect of
ABS on the toxicity of Cd on the lung.
Material and Method
Thirty two rats were used in the study, and they were
divided into 4 groups, with 8 rats in each group:
control, Kd (2.5 mg/kg single dose ip), ABS (1.5 ml/
kg single dose ip), and Kd+ABS (Kd, 2,5 mg/kg single
dose ip-ABS, 1.5 ml/kg single dose ip). Lung tissues
were evaluated histopathologically. Inflammation
was evaluated immunohistochemically with tumor
necrosis factor-α (TNF-α). Oxidative stress was
evaluated with the total oxidant level (TOS) and total
antioxidant level (TAS) using the spectrophotometric
method. Apoptosis was evaluated using RT-PCR with
relative mRNA fold changes of Bcl-2-associated X
(Bax), B-cell lymphoma 2 (Bcl-2), cytochrome c (Cyt
c), and caspase 3 genes.
Results
Histopathological findings such as congestion,
hemorrhage, and mononuclear cell infiltration were
found to increase in the Cd group. It was found that
Cd increased inflammation by increasing TNF-α,
increasing TOS and OSI, and decreasing TAS,
causing an increase in oxidative stress. (p
Clinical profile of congenital heart disease in children with special reference to echo correlation
Authors: Patra Upasana , Agarwalla Sunil Kumar , Das Bharati 
Published: June 2023

Background: Congenital heart disease (CHD) is the most frequently occurring congenital disorder responsible for 1/3rd of all congenital birth defects. Diagnostic accuracy of CHD is crucial for timely intervention and optimal patient outcome. So, the study has been done to look for the clinical profile and establishing correlation of clinical diagnosis with echocardiography diagnosis.
Methods: This is a prospective cross-sectional study conducted in the department of pediatrics MKCG MCH, Berhampur over a period of 2 years. All children between 1 month to 14 years admitted for suspected CHD were included in the study. Clinical diagnosis was made based on detailed history and physical examination supported by chest X-ray and ECG. Final diagnosis was confirmed by echocardiography and clinico-ECHO correlation was deduced.
Results: The 188 patients with CHD were included in this study. The most common age of presentation was 1 month to 1 year with 71.2%, male to female ratio was 1.06:1. Acyanotic CHD (ACHD) was found to be 70.29%, while 29.7% had congenital cyanotic heart disease (CCHD). Clinically specific diagnosis was attributed to 67.1% of cases and no specific diagnosis could be made in 32.9%. Isolated CHD was found to be 66.4% and Complex CHD with multiple defects was found to be 33.6%. Clinic echo correlation was accurate in 39.4% cases, partially correlated in 32% and no correlation in 28.6% cases.
Conclusions: So, echocardiography remains the gold standard for diagnosis of CHD and guiding the treatment. Clinical diagnosis alone may not detect associated CHD.
effect of fatty acid’s dielectric constant in the generation of surface plasmons using numerical attenuated total reflection (ATR)
Authors: Gunawan Vincensius 
Published: June 2023

The surface plasmons were collective excitation of free charges which can be generated at the interface between metal and dielectrics. The active material was metal which provided free charges while dielectrics was passive material which maintained the electric fields at the interface. One of the most effective method to generate surface plasmons was attenuated total reflection (ATR). The basic concept of this method was total internal reflection. Hence, it required a high index prism, such as thallium halogenide. The ATR method can be done numerically by deriving ATR reflectivity. In the process of derivation, we should consider the reflectivity at the all involved interfaces. Then, the ATR reflectivity can be obtained by scanning frequency at the certain interval near the surface plasmon frequency. In this report, we study the surface plasmon which was generated at the interface between gold and fatty acid. We analysed the effect of fatty acid’s dielectric constant to the ATR spectroscopy. We found that the decrease of the fatty acid’s permittivity increase the surface plasmon resonance (SPR frequency and decrease the reflectivity at this resonance frequency.
Carotid Body Enlargement in Patients with Hypertension and Comorbid Diseases: a CT Angiographic Study
Authors: ÖZER Gözde , DAMGACI Lale 
Published: June 2023

Aim: To determine the carotid body (CB) size and its relationship with hypertension, other sympathetically mediated disorders and smoking.
Materials and Methods: Neck CT angiographies of 180 patients performed in our clinic in the previous year were included in the study. The patients' histories were assessed for hypertension (HT), congestive heart failure (CHF), diabetes mellitus (DM), chronic obstructive pulmonary disease and smoking. The study groups were smokers without any chronic condition (S group, n=21), patients with HT alone (HT group, n=26), patients that had at least two chronic disorders (CD+S group, n=78) and the controls (n=33). The widest axial diameter of the CB was measured on axial sections.
Results: CB diameter could be measured in 158 patients. The CB diameter was significantly greater in HT (2.77±3.28 mm, p=0.02) and CD+S (2.76±3.38 mm, p
Aynı marka cihazlarda çalışılan testlerin six sigma metrikleri ile analitik performansının değerlendirilmesi
Authors: DUNDAR Bagnu , HALIPCI TOPSAKAL Hatıce Nur 
Published: June 2023

Amaç: Altı sigma ile analitik testlerin istenilen kalitede olup olmadığı ve kalitenin sayısal değeri görülebilir. Laboratuvarlara sunulan testlerin yöntem kalitesini değerlendirmek, cihazlar arasında yöntem performansını karşılaştırmak, kalite kontrol prosedürlerini yeniden gözden geçirmek konusunda altı sigma metriklerinden faydalanılmaktadır.
Gereç ve Yöntemler: Bu çalışmanın amacı; laboratuvarda aktif çalışılan aynı marka cihazlar arasındaki altı sigma metrikleri ile analitik performansın değerlendirilmesi ve laboratuvar test çalışma hızına göre bu cihazlarda hangi testlerin çalışılıp çalışılmayacağı sorusuna yanıt bulmaktır. Yapılan araştırmada bütün testler ABBOTT marka Architeck c 8000 ve Architeck ci 4000 cihazlarında 6 ay süre ile çalışılmıştır. Glukoz (Glc), üre (BUN), kreatinin (CREA), aspartat aminotransferaz (AST), total kolesterol (CHOL), trigliseritler (Tg), Sodyum (Na), potasyum (K), klor (Cl) parametreleri değerlendirilmiş testlerin sigma değerleri performans yaklaşımına göre hesaplanmış ve cihazlar arasında karşılaştırma yapılmıştır. Toplam kabul edilebilir hata ( TEa), Klinik Laboratuvarları İyileştirme Yasası (CLIA) klavuzlarından alınmıştır. Bias, yeterlilik test verilerine göre belirlenmiştir. Biyokimyasal analitler için varyasyon katsayısı (CV) laboratuvarımızın IQC kayıtlarından elde edilmiştir. Sigma metrikleri (SM) = ( TEa-%Bias )/ %CV formülüne göre hesaplanmıştır
Bulgular: 6 ay boyunca yapılan karşılaştırılmalı takipte ay bazında hangi cihazda çalışılması gereken parametrelerin belirlenmesi değişkenlik göstermiştir. Laboratuvarımızda en fazla çalışılan glucose, urea ve creatinine testlerinin Architeck ci 4000 cihazında sigma değerleri Architeck c8000 cihazından daha düşük olduğu için bu testlerin sadece c8000 cihazında çalışılmasına karar verildi. Elde edilen metriklere göre, 2019 Ekim ayından itibaren başlattığımız çalışmada altı ay sonra elektrolitlerin tek cihazda çalışılmaya başlanması ile sigma değerinde artış tespit edildi.
Sonuç: Altı sigma metrikleri, binlerce test yapılan aynı marka cihazların yöntem performansını değerlendirmede aylık olarak özellikle düşük biyolojik varyasyona sahip testleri takip etmek için kullanılmalıdır.
Diagnostic Accuracy and Safety of Ultrasound Guided Omental Biopsy: Single Center Experience
Authors: ÖZEN Özgür , ZEYDANLI Tolga , KİRİSCİ Batuhan , KARAKAYA Emre 
Published: June 2023

Aim: Omental biopsy has conventionally been performed using a surgical approach. The thickened omentum can serve as a useful target for ultrasonography guided percutaneous biopsy, in clinical practice. The objective of our study was to determine the diagnostic value and safety of ultrasound guided percutaneous biopsy of omental thickening. Additionally, we aim to investigate the correlation of biopsy results with the paracentesis fluid cytology.
Methods: This retrospective study included 49 patients (33 women and 16 men; mean age, 64 ± 13.9 [SD] years) who underwent ultrasound guided omental biopsy between 2014 and 2022 at a single institution at which US served as the first-line modality for omental biopsy guidance. Post-biopsy clinical follow-up were reviewed for each patient. We compare the outcomes of biopsy and paracentesis fluid cytology results.
Results: Total 49 patients were included in our study. US-guided biopsy was diagnostic in 46/49 (93.8%) of patients. There were total 36 (73.4%) malignant cases, 5 (10.2%) chronic inflammation suggestive of tuberculosis, while 2 (4.1%) were chronic peritoneal infection. In 3 patients, the result of core biopsy was benign and reported as Ig4-related inflammatory pseudotumor, desmoid fibromatosis and fat necrosis-foreign body reaction. Out of 36 malignant cases, majority 17 (47.2%) had ovarian cancer. There were no major complications. In 21 of 25 patients (%84) who underwent paracentesis fluid sampling, cytology results (malign or bening cytology) were found to be consistent with omental biopsy results. The ascitic cytological evaluation was favourable for malignancy in 16/25 (64%) patients.

Conclusions: Ultrasound-guided percutaneous biopsy of omentum is less expensive, safe and effective method with a high diagnostic accuracy. Paracentesis fluid cytology results are highly sensitive in patients with omental thickening.
СТРАТЕГІЧНІ НАПРЯМИ ПІДВИЩЕННЯ ІННОВАЦІЙНОЇ АКТИВНОСТІ ПІДПРИЄМСТВ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ
Authors: Кузнецов Є. М. 
Published: June 2023

В статті досліджено підходи до визначення змісту інноваційної активності, що лягло в основу формулювання авторського розуміння категорії «інноваційна активність підприємств залізничного транспорту». Окреслено специфіку інноваційної діяльності підприємств залізничного транспорту та визначено причини загальнодержавного і галузевого впливу, що зумовлюють низький рівень інноваційної активності підприємств галузі. Обґрунтовано стратегічні напрями підвищення інноваційної активності підприємств залізничного транспорту.