bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serial Urinary C-C Motif Chemokine Ligand 14 and Risk of Persistent Severe Acute Kidney Injury
Authors: Prowle John R. , Artigas Antonio , Bagshaw Sean M. , Forni Lui G. , Heung Michael , Hoste Eric , Marlies Ostermann , Koyner Jay L. , Chawla Lakmir , Kampf J. Patrick , Kwan Thomas , McPherson Paul , Kellum John A. ,   for the Sapphire and Ruby Investigators
Published: March 2023

OBJECTIVES:
To assess the added prognostic value of serial monitoring of urinary C-C motif chemokine ligand 14 (uCCL14) over that of single measurements, which have been shown to be prognostic for development of persistent severe acute kidney injury (AKI) in critically ill patients.

DESIGN:
Retrospective observational study.

SETTING:
Data derived from two multinational ICU studies (Ruby and Sapphire).

PATIENTS:
Critically ill patients with early stage 2–3 AKI.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
We analyzed three consecutive uCCL14 measurements at 12-hour intervals after diagnosis of stage 2–3 AKI by Kidney Disease Improving Global Outcomes criteria. Primary outcome was persistent severe AKI, defined as 72 consecutive hours of stage 3 AKI, death, or receipt of dialysis prior to 72 hours. uCCL14 was measured using the NEPHROCLEAR uCCL14 Test on the Astute 140 Meter (Astute Medical, San Diego, CA). Based on predefined, validated cutoffs, we categorized uCCL14 as: low (≤ 1.3 ng/mL), medium (> 1.3 to ≤ 13 ng/mL), or high (> 13 ng/mL). Seventy-five of 417 patients with three consecutive uCCL14 measurements developed persistent severe AKI. Initial uCCL14 category strongly correlated with primary endpoint and, in most cases (66%), uCCL14 category was unchanged over the first 24 hours. Compared with no change and accounting for baseline category, decrease in category was associated with decreased odds of persistent severe AKI (odds ratio [OR], 0.20; 95% CI, 0.08–0.45; p < 0.001) and an increase in category with increased odds (OR, 4.04; 95% CI, 1.75–9.46; p = 0.001).

CONCLUSIONS:
In one-third of patients with moderate to severe AKI uCCL14 risk category altered over three serial measurements and such changes were associated with altered risk for persistent severe AKI. Serial CCL-14 measurement may detect progression or resolution of underlying kidney pathology and help refine AKI prognosis.
Hemorrhage, Disseminated Intravascular Coagulopathy, and Thrombosis Complications Among Critically Ill Patients with COVID-19: An International COVID-19 Critical Care Consortium Study*
Authors: Fanning Jonathon P. , Weaver Natasha , Fanning Robert B. , Griffee Matthew J. , Cho Sung-Min , Panigada Mauro , Obonyo Nchafatso G. , Zaaqoq Akram M. , Rando Hannah , Chia Yew Woon , Fan Bingwen Eugene , Sela Declan , Chiumello Davide , Coppola Silvia , Labib Ahmed , Whitman Glenn J. R. , Arora Rakesh C. , Kim Bo S. , Motos Anna , Torres Antoni , Barbé Ferran , Grasselli Giacomo , Zanella Alberto , Etchill Eric , Usman Asad Ali , Feth Maximilian , White Nicole M. , Suen Jacky Y. , Li Bassi Gianluigi , Peek Giles J. , Fraser John F. , Dalton Heidi ,   on behalf of the COVID-19 Critical Care Consortium
Published: March 2023

OBJECTIVES:To determine the prevalence and outcomes associated with hemorrhage, disseminated intravascular coagulopathy, and thrombosis (HECTOR) complications in ICU patients with COVID-19.DESIGN:Prospective, observational study.SETTING:Two hundred twenty-nine ICUs across 32 countries.PATIENTS:Adult patients (≥ 16 yr) admitted to participating ICUs for severe COVID-19 from January 1, 2020, to December 31, 2021.INTERVENTIONS:None.MEASUREMENTS AND MAIN RESULTS:HECTOR complications occurred in 1,732 of 11,969 study eligible patients (14%). Acute thrombosis occurred in 1,249 patients (10%), including 712 (57%) with pulmonary embolism, 413 (33%) with myocardial ischemia, 93 (7.4%) with deep vein thrombosis, and 49 (3.9%) with ischemic strokes. Hemorrhagic complications were reported in 579 patients (4.8%), including 276 (48%) with gastrointestinal hemorrhage, 83 (14%) with hemorrhagic stroke, 77 (13%) with pulmonary hemorrhage, and 68 (12%) with hemorrhage associated with extracorporeal membrane oxygenation (ECMO) cannula site. Disseminated intravascular coagulation occurred in 11 patients (0.09%). Univariate analysis showed that diabetes, cardiac and kidney diseases, and ECMO use were risk factors for HECTOR. Among survivors, ICU stay was longer (median days 19 vs 12;p< 0.001) for patients with versus without HECTOR, but the hazard of ICU mortality was similar (hazard ratio [HR] 1.01; 95% CI 0.92–1.12;p= 0.784) overall, although this hazard was identified when non-ECMO patients were considered (HR 1.13; 95% CI 1.02–1.25;p= 0.015). Hemorrhagic complications were associated with an increased hazard of ICU mortality compared to patients without HECTOR complications (HR 1.26; 95% CI 1.09–1.45;p= 0.002), whereas thrombosis complications were associated with reduced hazard (HR 0.88; 95% CI 0.79–0.99,p= 0.03).CONCLUSIONS:HECTOR events are frequent complications of severe COVID-19 in ICU patients. Patients receiving ECMO are at particular risk of hemorrhagic complications. Hemorrhagic, but not thrombotic complications, are associated with increased ICU mortality.
Real-Time Ultrasound Guidance as Compared With Landmark Technique for Subclavian Central Venous Cannulation: A Systematic Review and Meta-Analysis With Trial Sequential Analysis*
Authors: Zawadka Mateusz , La Via Luigi , Wong Adrian , Olusanya Olusegun , Muscarà Liliana , Continella Carlotta , Andruszkiewicz Pawel , Sanfilippo Filippo 
Published: March 2023

OBJECTIVES:
We conducted a systematic review and meta-analysis to assess the effectiveness of real-time dynamic ultrasound-guided subclavian vein cannulation as compared to landmark technique in adult patients.

DATA SOURCES:
PubMed and EMBASE until June 1, 2022, with the EMBASE search restricted to the last 5 years.

STUDY SELECTION:
We included randomized controlled trials (RCTs) comparing the two techniques (real-time ultrasound-guided vs landmark) for subclavian vein cannulation. The primary outcomes were overall success rate and complication rate, whereas secondary outcomes included success at first attempt, number of attempts, and access time.

DATA EXTRACTION:
Independent extraction by two authors according to prespecified criteria.

DATA SYNTHESIS:
After screening, six RCTs were included. Two further RCTs using a static ultrasound-guided approach and one prospective study were included in the sensitivity analyses. The results are presented in the form of risk ratio (RR) or mean difference (MD) with 95% CI. Real-time ultrasound guidance increased the overall success rate for subclavian vein cannulation as compared to landmark technique (RR = 1.14; [95% CI 1.06–1.23]; p = 0.0007; I
2 = 55%; low certainty) and complication rates (RR = 0.32; [95% CI 0.22–0.47]; p < 0.00001; I
2 = 0%; low certainty). Furthermore, ultrasound guidance increased the success rate at first attempt (RR = 1.32; [95% CI 1.14–1.54]; p = 0.0003; I
2 = 0%; low certainty), reduced the total number of attempts (MD = –0.45 [95% CI –0.57 to –0.34]; p < 0.00001; I
2 = 0%; low certainty), and access time (MD = –10.14 s; [95% CI –17.34 to –2.94]; p = 0.006; I
2 = 77%; low certainty). The Trial Sequential Analyses on the investigated outcomes showed that the results were robust. The evidence for all outcomes was considered to be of low certainty.

CONCLUSIONS:
Real-time ultrasound-guided subclavian vein cannulation is safer and more efficient than a landmark approach. The findings seem robust although the evidence of low certainty.
Surgical resection for a huge right ventricular hemangioma
Authors: Yang Jen Chen , Chen I Chen , Chang Chung Yi , Wei Jeng 
Published: March 2023

Abstract
Cardiac hemangiomas are particularly rare entities, are often asymptomatic, and are often merely observed because of its slow growth and benign nature. We report a 52-year-old male patient who presented with exercise intolerance and chest discomfort due to the mass effect of a large 14 × 10 × 6-cm epicardial hemangioma. The tumor arose from the recess between the aorta and main pulmonary artery and featured a prominent feeding artery from the right coronary artery. The tumor was successfully resected, and pathology confirmed the diagnosis of cavernous hemangioma. We review the clinical features, imaging characteristics, pathological findings, and prognosis of cardiac hemangiomas.
Cognitive Behavioral Therapy Enhances Survival in Cardiac Patients Aged Under 60
Authors: Murphy Barbara M. , Navaratnam Hema S. , Le Grande Michael R. , Higgins Rosemary O. , Rogerson Michelle C. , Elliott Peter , Worcester Marian U. C. , Jackson Alun C. 
Published: March 2023

Purpose:
To optimize recovery and improve prognosis, people who have had an acute cardiac event (ACE) need support to manage their cardiac risk. In 2008, we conducted a randomized controlled trial (RCT) of Beating Heart Problems (BHP), an 8-wk group program based on cognitive behavioral therapy (CBT) and motivational interviewing (MI), designed to improve behavioral and mental health. This study investigated 14-yr mortality status for RCT participants in order to evaluate the survival impact of the BHP program.

Methods:
In 2021, mortality data on 275 participants from the earlier RCT were obtained from the Australian National Death Index. Survival analysis was undertaken to investigate differences in survival for participants in the treatment and control groups.

Results:
Over the 14-yr follow-up period, there were 52 deaths (18.9%). For those aged <60 yr, there was a significant survival benefit to program participation, with 3% deaths in the treatment group and 13% deaths in the control group (P = .022). For those aged ≥60 yr, the death rate was identical in both groups (30%). Other significant predictors of mortality included older age, higher 2-yr risk score, lower functional capacity, lower self-rated health, and having no private health insurance.

Conclusions:
Participation in the BHP conferred a survival benefit for patients aged <60 yr but not for participants overall. The findings highlight the long-term benefit of behavioral and psychosocial management of cardiac risk through CBT and MI for those who are younger at the time of their first ACE.
Oxygen Uptake Efficiency Slope in South American Healthy Adults
Authors: Milani Juliana Goulart Prata Oliveira , Milani Mauricio , Cipriano Graziella França Bernardelli , de Castro Isac , Hansen Dominique , Cipriano Junior Gerson 
Published: March 2023

Purpose:The purpose of this study is to provide comprehensive reference values for oxygen uptake efficiency slope (OUES) in healthy adults. International heterogeneity was also explored through published databases.Methods:A cross-sectional study was conducted with treadmill cardiopulmonary exercise testing (CPX) from a Brazilian healthy adult sample, in which absolute OUES and values normalized by weight and body surface area (BSA) were calculated. Data were stratified by sex and age group. Prediction equations were calculated using age and anthropometric variables. International data were pooled and differences were explored using factorial analysis of variance or thettest, as appropriate. The OUES age-related patterns were calculated using regression analysis.Results:A total of 3544 CPX were included (1970 males and 1574 females) and the age ranged from 20-80 yr. Males had higher values than females for OUES, OUES/kg, and OUES/BSA. Lower values were found with aging and the data followed a quadratic regression curve. Reference value tables and predictive equations were provided for absolute and normalized OUES in both sexes. International comparisons of absolute OUES values among Brazilian, European, and Japanese data revealed substantial heterogeneity. The OUES/BSA measure minimized the discrepancies between Brazilian and European data.Conclusions:Our study provided comprehensive OUES reference values in a large healthy adult sample from South America with a wide age range and included absolute and normalized values. Differences observed between Brazilian and European data were reduced in the BSA-normalized OUES.
Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation
Authors: de Carvalho Ribeiro Marcelle , Iracheta-Vellve Arvin , Babuta Mrigya , Calenda Charles D. , Copeland Christopher , Zhuang Yuan , Lowe Patrick P. , Hawryluk Danielle , Catalano Donna , Cho Yeonhee , Barton Bruce , Dasarathy Srinivasan , McClain Craig , McCullough Arthur J. , Mitchell Mack C. , Nagy Laura E. , Radaeva Svetlana , Lien Egil , Golenbock Douglas T. , Szabo Gyongyi 
Published: March 2023

Background & Aims:
Prolonged systemic inflammation contributes to poor clinical outcomes in severe alcohol-associated hepatitis (AH) even after the cessation of alcohol use. However, mechanisms leading to this persistent inflammation remain to be understood.

Approach & Results:
We show that while chronic alcohol induces nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in the liver, alcohol binge results not only in NLRP3 inflammasome activation but also in increased circulating extracellular apoptosis-associated speck-like protein containing a caspase recruitment domain (ex-ASC) specks and hepatic ASC aggregates both in patients with AH and in mouse models of AH. These ex-ASC specks persist in circulation even after the cessation of alcohol use. Administration of alcohol-induced–ex-ASC specks in vivo in alcohol-naive mice results in sustained inflammation in the liver and circulation and causes liver damage. Consistent with the key role of ex-ASC specks in mediating liver injury and inflammation, alcohol binge failed to induce liver damage or IL-1β release in ASC-deficient mice. Our data show that alcohol induces ex-ASC specks in liver macrophages and hepatocytes, and these ex-ASC specks can trigger IL-1β release in alcohol-naive monocytes, a process that can be prevented by the NLRP3 inhibitor, MCC950. In vivo administration of MCC950 reduced hepatic and ex-ASC specks, caspase-1 activation, IL-1β production, and steatohepatitis in a murine model of AH.

Conclusions:
Our study demonstrates the central role of NLRP3 and ASC in alcohol-induced liver inflammation and unravels the critical role of ex-ASC specks in the propagation of systemic and liver inflammation in AH. Our data also identify NLRP3 as a potential therapeutic target in AH.
Influence of Personal and Injury-Related Factors Predicting Deficits in Quality of Life Domains Among Pediatric Athletes: Findings From the Sport Concussion Outcomes in Pediatrics Study
Authors: Valovich McLeod Tamara C. , Snedden Traci , Halstead Mark , Wilson Julie , Master Christina , Grady Matthew , Fazekas Matthew , Santana Jonathan , Zaslow Tracy , Miller Shane , Coel Rachel , Howell David R. ,   The PRiSM Concussion Research Interest Group
Published: March 2023

Objective:
To examine patient and injury factors that may predict quality of life (QoL) and symptom duration after concussion.

Design:
Prospective, longitudinal.

Settings:
Six children's hospital-based medical centers and 9 secondary school athletic training facilities.

Patients:
Pediatric patients (8-18 years) were enrolled as part of the Sport Concussion Outcomes in Pediatrics (SCOPE) study during their initial visit for a diagnosis of sport-related concussion.

Interventions:
Patients completed a medical history, the Postconcussion Symptom Inventory (PCSI), and Patient-Reported Outcomes Measurement Information System Pediatric Profile-25 (PROMIS-PP).

Main Outcome Measures:
Eight predictor variables [age, sex, assessment time, loss of consciousness, amnesia and history of concussion, migraines, or attention-deficit hyperactivity disorder or (ADHD)] were assessed using regression models constructed for each dependent variable.

Results:
A total of 244 patients (15.1 ± 2.1 years, 41% female) were enrolled (mean = 5 ± 3 days after concussion; range = 1-14 days). Female sex, later initial assessment, and presence of amnesia were associated with lower QoL scores on several domains, whereas loss of consciousness was associated with higher QoL for fatigue. A history of migraines was associated with lower peer relationship QoL. Patients who subsequently developed persisting symptoms had lower mobility scores and higher anxiety, depressive symptom, fatigue, and pain interference scores.

Conclusions:
Female sex, later clinic presentation, and amnesia were associated with a lower QoL related to mobility, anxiety, depressive symptoms, fatigue, and pain interference. Interestingly, previous concussion and preinjury ADHD diagnosis did not negatively impact postinjury QoL at the initial visit. Future studies should assess the influence of these factors on QoL at later postinjury time points using a concussion-specific outcomes instrument.
Comparative efficacy and safety of different hemostatic medications during spinal surgery: A network meta-analysis
Authors: Tan Haitao , Pan Songli , Wei Chuanchun , Chen Zhilin , Chen Tao 
Published: March 2023

Background:
Significant blood loss is still one of the most frequent issues in spinal surgery. There were different hemostatic methods to prevent blood loss during spinal surgery. However, the optimal hemostatic therapy for spinal surgery is controversial. The purpose of this study was to assess the efficacy and safety of different hemostatic therapies in spinal surgery.

Methods:
Two independent reviewers conducted electronic literature searches in 3 electronic databases (PubMed, Embase, and Cochrane library database) as well as a manual search to identify eligible clinical studies from inception to Nov 2022. Studies that including different hemostatic therapy (tranexamic acid [TXA], epsilon-acetyl aminocaproic acid [EACA], and aprotinin [AP]) for spinal surgery were included. The Bayesian network meta-analysis was performed with a random effects model. The surface under the cumulative ranking curve (SUCRA) analysis was performed to determine the ranking order. All analyses were performed by R software and Stata software. P value less than .05 was identified as statistically significant.

Results:
Finally, a total of 34 randomized controlled trials met the inclusion criteria and finally included in this network meta-analysis. The SUCRA shows that TXA ranked first (SUCRA, 88.4%), AP ranked second (SUCRA, 71.6%), EACA ranked third (SUCRA, 39.9%), and placebo ranked the last (SUCRA, 0.3%) as for total blood loss. The SUCRA shows that TXA ranked first (SUCRA, 97.7%), AP ranked second (SUCRA, 55.8%), EACA ranked third (SUCRA, 46.2%), and placebo ranked the last (SUCRA, 0.2%) for need for transfusion.

Conclusions:
TXA appears optimal in the reduction of perioperative bleeding and blood transfusion during spinal surgery. However, considering the limitations in this study, more large-scale, well-designed randomized controlled trials are needed to confirm these findings.
Diagnostic value of magnetic resonance imaging and magnetic resonance arthrography for assessing acetabular labral tears: A systematic review and meta-analysis
Authors: Huang Zhihao , Liu Wenyu , Li Tianyu , Liu Zhihao , Zhao Pengfei 
Published: March 2023

Background:
This study aimed to systematically evaluate the value of magnetic resonance imaging (MRI) and magnetic resonance arthrography (MRA) in the diagnosis of acetabular labral tears.

Methods:
Databases including PubMed, Embase, Cochrane Library, Web of Science, CBM, CNKI, WanFang Data, and VIP were electronically searched to collect relevant studies on magnetic resonance in the diagnosis of acetabular labral tears from inception to September 1, 2021. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias in the included studies by using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. RevMan 5.3, Meta Disc 1.4, and Stata SE 15.0 were used to investigate the diagnostic value of magnetic resonance in patients with acetabular labral tears.

Results:
A total of 29 articles were included, involving 1385 participants and 1367 hips. The results of the meta-analysis showed that the pooled sensitivity, pooled specificity, pooled positive likelihood ratio, pooled negative likelihood ratio, pooled diagnostic odds ratio, area under the curve of the summary receiver operating characteristic, and Q* of MRI for diagnosing acetabular labral tears were 0.77 (95% confidence interval [CI], 0.75–0.80), 0.74 (95% CI, 0.68–0.80), 2.19 (95% CI, 1.76–2.73), 0.48 (95% CI, 0.36–0.65), 4.86 (95% CI, 3.44–6.86), 0.75, and 0.69, respectively. The pooled sensitivity, pooled specificity, pooled positive likelihood ratio, pooled negative likelihood ratio, pooled diagnostic odds ratio, area under the curve of the summary receiver operating characteristic, and Q* of MRA for diagnosing acetabular labral tears were 0.87 (95% CI, 0.84–0.89), 0.64 (95% CI, 0.57–0.71), 2.23 (95% CI, 1.57–3.16), 0.21 (95% CI, 0.16–0.27), 10.47 (95% CI, 7.09–15.48), 0.89, and 0.82, respectively.

Conclusion:
MRI has high diagnostic efficacy for acetabular labral tears, and MRA has even higher diagnostic efficacy. Due to the limited quality and quantity of the included studies, the above results should be further validated.
Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer
Authors: Li Jiaying , Li Li , Mahesutihan Gulijiang , Meng Juanjuan , Chen Yuan , Lv Jingsen 
Published: March 2023

Background:
Breast invasive cancer (BRCA) is the most common malignancy and the second leading cause of malignancy death among women. Signal transducers and activators of transcription (STAT) family played a vital role in regulating certain biological processes and could serve as biomarkers for many diseases or cancers.

Methods:
The expression, prognostic value, and clinical functions of STAT family in BRCA were evaluated with several bioinformatics web portals.

Results:
The expression of STAT5A/5B were downregulated in BRCA in subgroup analyses based on race, age, gender, race, subclasses, tumor histology, menopause status, nodal metastasis status, and TP53 mutation. BRCA patients with high STAT5B expression had a better overall survival, relapse free survival, MDFS and post progression survival. STAT5B expression level can impact the prognosis in BRCA patients with positive PR status, negative Her2 status and wild type TP53. Moreover, STAT5B was positively correlated with immune cell infiltration and the level of immune biomarkers. Drug sensitivity revealed that low STAT5B expression was resistant to the many small molecules or drugs. Functional enrichment analysis revealed that STAT5B was involved in adaptive immune response, translational initiation, JAK-STAT signaling pathway, Ribosome, NF-kappa B signaling pathway and Cell adhesion molecules.

Conclusions:
STAT5B was a biomarker associated with prognosis and immune infiltration in breast cancer.