bluuebunny/crossref_metadata_2025_split huggingface dataset:
The under-loading cascading failure model: a tool for assessing the vulnerability of SME cooperation networks
Authors: Yin Hang , Hou Jishan , Gong Chengju , Xu Chen 
Published: March 2023

PurposeThe behavior of the entities in a small and medium-sized enterprise (SME) cooperation network is influenced by the core enterprise. Addressing the problem of how the network vulnerability changes when the core enterprise is attacked is a challenging topic. The purpose of this paper is to reveal the failure process of SME cooperation networks caused by the failure of the core SME from the perspective of cascading failure.Design/methodology/approachAccording to the Torch High Technology Industry Development Center, Ministry of Science & Technology in China, 296 SMEs in Jiangsu province were used to construct an SME cooperation network of technology-based SMEs and an under-loading cascading failure model. The weight-based attack strategy was selected to mimic a deliberate node attack and was used to analyze the vulnerability of the SME cooperation network.FindingsSome important conclusions are obtained from the simulation analysis: (1) The minimum boundary of node enterprises has a negative relationship with networks' invulnerability, while the breakdown probability has an inverted-U relationship with networks' invulnerability. (2) The combined effect of minimum boundary and breakdown probability indicates that the vulnerability of networks is mainly determined by the breakdown probability; while, minimum boundary helps prevent cascading failure occur. Furthermore, according to the case study, adapting capital needs and resilience in the cooperation network is the core problem in improving the robustness of SME cooperation networks.Originality/valueThis research proposed an under-loading cascading failure model to investigate the under-loading failure process caused by the shortage of resources when the core enterprise fails or withdraws from the SME cooperation network. Two key parameters in the proposed model—minimum capacity and breakdown probability—could serve as a guide for research on the vulnerability of SME cooperation networks. Additionally, practical meanings for each parameter in the proposed model are given, to suggest novel insights regarding network protection to facilitate the robustness and vulnerability in real SME cooperation networks.
Challenges of primary health care leadership during the COVID-19 pandemic in Sweden: a qualitative study of managers’ experiences
Authors: Skagerström Janna , Fernemark Hanna , Nilsen Per , Seing Ida , Hårdstedt Maria , Karlsson Elin , Schildmeijer Kristina 
Published: March 2023

PurposeAt the outbreak of the COVID-19 pandemic, health care was at the centre of the crisis. New demands made existing organizational practices and services obsolete. Primary health care had a great deal of responsibility for COVID-19-related care. The pandemic demanded effective leadership to manage the new difficulties. This paper aims to explore experiences and perceptions of managers in primary health care in relation to their efforts to manage the COVID-19 crisis in their everyday work.Design/methodology/approachThe authors used a qualitative approach based on 14 semi-structured interviews with managers in primary health care from four regions in Sweden. The interviews were conducted during September to December 2020. Data were analysed using conventional qualitative content analysis.FindingsData analysis yielded three categories: lonely in decision-making; stretched to the limit; and proud to have coped. The participants felt lonely in their decision-making, and they were stretched to the limit of their own and the organization’s capacity. The psychosocial working conditions in primary care worsened considerably during the pandemic because demands on leaders increased while their ability to control the work situation decreased. However, they also expressed pride that they and their employees had managed the situation by being flexible and having a common focus.Originality/valueLooking ahead and using lessons learnt, and apart from making wise decisions under pressure, an important implication for primary health-care leaders is to not underestimate the power of acknowledging the virtues of humanity and justice during a crisis. Continuing professional education for leaders focusing on crisis leadership could help prepare leaders for future crises.
Exploring paths underlying Industry 4.0 implementation in manufacturing SMEs: a fuzzy-set qualitative comparative analysis
Authors: Marrucci Anna , Rialti Riccardo , Balzano Marco 
Published: March 2023

PurposeThe purpose of this article is to develop a configurational approach based on the TOE framework (technology, organization and environment) to understand the degree of implementation of I4.0 technologies in manufacturing small- and medium-sized enterprises (SMEs). Specifically, the study considers technological infrastructure and competence, I4.0 integration capabilities, organizational agility and strategic flexibility, environmental dynamism and industry-specific forces as simultaneous pre-conditions for achieving an effective implementation of I4.0 technologies.Design/methodology/approachThis study uses the fuzzy-set qualitative comparative analysis (fsQCA) methodology as it allows for asymmetric and configurational-focused testing of proposition and sound theoretical development. In total, 305 responses were collected through a survey administered to SME managers in Europe and the United Kingdom (UK).FindingsThe study examines the influence of technology, organizational and environmental aspects on I4.0 technologies implementation in SMEs. High I4.0 degree of implementation is structured around 5 configurations, while other 4 configurations are related to low levels of I4.0 implementation.Originality/valueThis study proposes a configurational approach for SMEs to become I4.0 ready and how they may successfully implement I4.0 technologies. Such findings represent an original and novel contribution to existing research, offering a broad view on the I4.0 implementation by manufacturing SMEs.
On to the next one? Using social network data to inform police target prioritization
Authors: Hashimi Sadaf , Bouchard Martin 
Published: March 2023

Purpose
Target prioritization is routinely done among law enforcement agencies, but the criteria to establish which targets will lead to the most crime reduction are neither systematic, nor do they take into account the networks in which offenders are embedded. The purpose of this paper is to propose network capital as a guide for prioritization exercises. The approach simultaneously considers a participant’s network centrality and their crime-affiliated attributes.

Design/methodology/approach
Data on all police interactions are used to map the social networks of two mutually connected police targets from a mid-size city in British Columbia, Canada. Network capital is captured by combining the extent to which individuals act as brokers between otherwise unconnected individuals (betweenness centrality), their number of contacts in the network (degree centrality), and whether they have a criminal record, gang ties, and a firearm carrier status.

Findings
The network comprises 101 associates, with nine mutual contacts amongst the two targets, and half of the network having a crime-affiliated attribute. Network capital directed the prioritization process to seven associates who stood out. Targeting strategies from two different investigative outcomes are compared.

Research limitations/implications
The specific recommendations of the study can only be interpreted within the context of the initial targets around which the network was constructed. As a prioritization approach, however, network capital is generalizable to other contexts with implications for law enforcement officials and, more broadly, the community.

Originality/value
The study provides insights into the practical application of network analysis with already existing police data. Network capital is data driven, which comes with its own limitations, but which constitutes an improvement over purely informal approaches to target prioritization.
The net primary productivity of early Permian peatland and their control factors: evidenced by the no. 6 coal seam of Jungar coalfield in North China
Authors: Hou Yijun , Wang Dongdong , Dong Guoqi 
Published: March 2023

Purpose
The purpose of this paper is to take the early Permian no.6 coal seam in Jungar coalfield of North China as an example, this paper studied the net primary productivity (NPP) level of the early Permian peatland and its relationship with the atmospheric environment at that time, analyzed the influence of the atmospheric environment, and discussed its control factors.

Design/methodology/approach
First, geophysical logging signals were used for a spectrum analysis to obtain the Milankovitch cycle parameters in the no. 6 coal seam, including the eccentricity (95 ka); obliquity (35.6 ka); and precession (21.2 ka). These were then used to calculate the accumulation rate of the residual carbon in the no. 6 coal seam, which was determined to be between 49.44 and 50.57 gC/(m2 · a). The carbon loss could be calculated according to the density and residual carbon content of the no. 6 coal seam. Then, the total carbon accumulation rate of the peatland was further derived as being between 64.91 and 66.40 gC/(m2 · a). Also, the NPP of the peatland was determined to be between 129.82 and 132.8 gC/(m2 · a).

Finding
The result showed that the NPP of the early Permian peatland area was lower than that of the Holocene at the same latitude, and also lower than that of the later Permian of South China.

Originality/value
This study’s comprehensive analysis indicated that the temperature and humidity conditions, along with the oxygen and carbon dioxide levels in the atmosphere, were the main control factors of the NPP of the early Permian peatland. Also, wildfires were found to play a role.
Towards a Framework Law on Sustainable Food Systems
Authors: Poppe Krijn 
Published: March 2023

SummaryThe European Commission has proposed a Framework Law on Sustainable Food Systems. To stimulate debate, this Point de Vue summarises the key messages of a policy brief by the European Environment and Sustainable Development Advisory Councils Network (EEAC). The European food system does not deliver sustainable diets with low environmental impacts which contribute to food and nutrition security and to a healthy life for present and future generations. An EU Framework should foster human and planetary health in a coherent and balanced approach between an agricultural supply policy, environmental policy and food (consumption) policy. It should direct the strong innovation capacity of actors away from ever lower food prices towards more sustainable farming, food processing and food consumption. However, a just transition is key: to the extent that healthy diets are not affordable for consumers, compensation should be given by changes in minimum wages, social security or income taxes. Different policy instruments are needed. Food system actors should not be exempted from economy‐wide measures like carbon pricing. Certification of all commercial farms, as an extension of methods in organic farming and private label certifications is needed. Labelling, sustainable procurement and a blending obligation would reward more sustainable producers and raise the average price of the product towards its true cost.
Trends in substance use disorder diagnoses among Veterans, 2009–2019
Authors: Hoggatt Katherine J. , Chawla Neetu , Washington Donna L. , Yano Elizabeth M. 
Published: March 2023

AbstractBackground and ObjectivesSubstance use disorder (SUD) represents a substantial health burden to US Veterans. We aimed to quantify recent time trends in Veterans' substance‐specific disorders using Veterans Health Administration (VA) data.MethodsWe identified Veteran VA patients for fiscal years (FY) 2010–2019 (October 1, 2009–September 9, 2019) and extracted patient demographics and diagnoses from electronic health records (~6 million annually). We defined alcohol, cannabis, cocaine, opioid, sedative, and stimulant use disorders with ICD‐9 (FY10–FY15) or ICD‐10 (FY16–FY19) codes and variables for polysubstance use disorder, drug use disorder (DUD), and SUD.ResultsDiagnoses for substance‐specific disorders (excluding cocaine), polysubstance use disorder, DUD, and SUD increased 2%–13% annually for FY10–FY15. Alcohol, cannabis, and stimulant use disorders increased 4%–18% annually for FY16–FY19, while cocaine, opioid, and sedative use disorders changed by ≤1%. Stimulant and cannabis use disorder diagnoses increased most rapidly, and older Veterans had the largest increases across substances.Discussion and ConclusionsRapid increases in cannabis and stimulant use disorder present a treatment challenge and key subgroups (e.g., older adults) may require tailored screening and treatment options. Diagnoses for SUD are increasing among Veterans overall, but there is important heterogeneity by substance and subgroup. Efforts to ensure access to evidence‐based treatment for SUD may require greater focus on cannabis and stimulants, particularly for older adults.Scientific SignificanceThese findings represent the first assessment of time trends in substance‐specific disorders among Veterans, overall and by age and sex. Notable findings include large increases in diagnoses for cannabis and stimulant use disorder and among older adults.
IL‐4 drastically decreases deuterosomal and multiciliated cells via alteration in progenitor cell differentiation
Authors: Cho Hyung‐Ju , Chung Youn Wook , Moon Sungmin , Seo Ju Hee , Kang Miran , Nam Jae Sung , Lee Sang‐Nam , Kim Chang‐Hoon , Choi Augustine M. K. , Yoon Joo‐Heon 
Published: March 2023

AbstractBackgroundAllergic inflammation affects the epithelial cell populations resulting in goblet cell hyperplasia and decreased ciliated cells. Recent advances in single‐cell RNA sequencing (scRNAseq) have enabled the identification of new cell subtypes and genomic features of single cells. In this study, we aimed to investigate the effect of allergic inflammation in nasal epithelial cell transcriptomes at the single‐cell level.MethodsWe performed scRNAseq in cultured primary human nasal epithelial (HNE) cells and in vivo nasal epithelium. The transcriptomic features and epithelial cell subtypes were determined under IL‐4 stimulation, and cell‐specific marker genes and proteins were identified.ResultsWe confirmed that cultured HNE cells were similar to in vivo epithelial cells through scRNAseq. Cell‐specific marker genes were utilized to cluster the cell subtypes, and FOXJ1+‐ciliated cells were sub‐classified into multiciliated and deuterosomal cells. PLK4 and CDC20B were specific for deuterosomal cells, and SNTN, CPASL, and GSTA2 were specific for multiciliated cells. IL‐4 altered the proportions of cell subtypes, resulting in a decrease in multiciliated cells and loss of deuterosomal cells. The trajectory analysis revealed deuterosomal cells as precursor cells of multiciliated cells and deuterosomal cells function as a bridge between club and multiciliated cells. A decrease in deuterosomal cell marker genes was observed in nasal tissue samples with type 2 inflammation.ConclusionThe effects of IL‐4 appear to be mediated through the loss of the deuterosomal population, resulting in the reduction in multiciliated cells. This study also newly suggests cell‐specific markers that might be pivotal for investigating respiratory inflammatory diseases.
Green synthesis of gold nanoparticles modulates lipopolysaccharide‐induced lung inflammation in Wistar rats
Authors: Casagrande Laura de R. , Porto Germano D. , Colares Mateus C. , Venturini Ligia M. , Silveira Gustavo de B. , Mendes Carolini , Corrêa Maria Eduarda A. B. , Lima Igor R. , Feuser Paulo E. , Machado‐de‐Ávila Ricardo A. , Silveira Paulo C. L. 
Published: March 2023

AbstractThis study aimed to investigate the effect of intranasal treatment of gold nanoparticles (GNPs) and Curcumin (Cur) on the lipopolysaccharide (LPS)‐induced acute pulmonary inflammatory response. A single intraperitoneal injection of LPS (0.5 mg/Kg) was performed, and the animals in the Sham group were injected with 0.9% saline. Treatment was daily intranasally with GNPs (2.5 mg/L), Cur (10 mg/kg) and GNP‐Cur started 12 h after LPS administration and ended on the seventh day. The results show that the treatment performed with GNP‐Cur was the most effective to attenuate the action of pro‐inflammatory cytokines, and a lower leukocyte count in the bronchoalveolar lavage, in addition to positively regulating anti‐inflammatory cytokines in relation to other groups. As a result, it promoted an oxirreductive balanced environment in the lung tissue, providing a histological outcome with a reduction in inflammatory cells and greater alveolar area. The group treated with GNPs‐Cur was superior to the other groups, with better anti‐inflammatory activity and reduced oxidative stress, resulting in less morphological damage to lung tissue. In conclusion, the use of reduced GNPs with curcumin demonstrates promising effects in the control of the acute inflammatory response, helping to protect the lung tissue at the biochemical and morphological levels.
A systematic review and meta‐ethnography to explore people's experiences of psychotherapy for self‐harm
Authors: Haw Rebecca , Hartley Samantha , Trelfa Sarah , Taylor Peter J. 
Published: March 2023

AbstractBackgroundSelf‐harm is a major public health concern. Lifetime prevalence is high, and rates of self‐harm are rising; however, available interventions do not benefit everyone, and engagement with therapy can be low. Qualitative accounts allow for a greater understanding of what is helpful to individuals. This study aimed to synthesize the experiences of interventions for self‐harm, from participants who have participated in these themselves.MethodsParticipants had self‐harmed at least once and undergone an individual psychotherapeutic intervention for self‐harm. Papers not written or translated to the English language were excluded. Four databases (Medline, CINAHL, Web of Science and PsycINFO) were systematically searched and each paper was assessed using the CASP quality appraisal tool. A meta‐ethnographic approach to the synthesis was taken.ResultsTen studies encompassing 104 participants were included. Four overarching themes were developed and the importance of recognizing the person beyond the self‐harm emerged through a line of argument synthesis. Building a trusted, therapeutic relationship founded on patience and without judgement was essential for the perceived success of therapy, which was unique to each person and often went beyond reducing self‐harming behaviours.LimitationsPapers included in the study showed a lack of diversity with regard to ethnicity and gender.ConclusionsThe findings illustrate the importance of the therapeutic alliance when working with self‐harm. Clinical implications of this paper include the importance of utilizing key therapeutic competencies which should be considered fundamental to change within psychotherapeutic interventions for self‐harm, with the uniqueness of each patient recognized throughout.
Genotypic and phenotypic characterisation of RP2‐ and RPGR‐associated X‐linked inherited retinal dystrophy, including female manifestations
Authors: Kuruvilla Shilpa E. , Song Eileen , Raoof Naz , van Bysterveldt Katherine , Oliver Verity F. , Hong Sheng Chiong , Al‐Taie Rasha , Wilson Graham , Vincent Andrea L. 
Published: March 2023

AbstractBackgroundWith the promise of gene replacement therapy, eligible males and females with X‐linked inherited retinal dystrophy (XL‐IRD) should be identified.MethodsRetrospective observational cohort study to establish the phenotypic and genotypic spectrum of XL‐IRD within New Zealand (NZ). Thirty‐two probands, including 9 females, with molecularly proven XL‐IRD due to RP2 or RPGR mutations, and 72 family members, of which 43 were affected, were identified from the NZ IRD Database. Comprehensive ophthalmic phenotyping, familial cosegregation, genotyping, and bioinformatics were undertaken. Main outcome measures were: RP2 and RPGR pathogenic variant spectrum, phenotype in males and females (symptoms, age of onset, visual acuity, refraction, electrophysiology, autofluorescence, retinal appearance), and genotype–phenotype correlation.ResultsFor 32 families, 26 unique pathogenic variants were identified; in RP2 (n = 6, 21.9% of all families), RPGR exons 1–14 (n = 10, 43.75%), and RPGR‐ORF15 (n = 10, 34.3%). Three RP2 and 8 RPGR exons 1–14 variants are novel, rare, and cosegregate. Thirty‐one percent of carrier females were significantly affected, with 18.5% of families initially classified as autosomal dominant. Of five Polynesian families, 80% had novel disease‐causing variants. One Māori family showed keratoconus segregating with an ORF15 variant.ConclusionsSignificant disease was present in 31% of genetically proven female carriers, often leading to an erroneous presumption of the inheritance pattern. Pathogenic variants in 44% of the families were in exon 1–14 of RPGR, more frequent than usually described, which may inform the gene testing algorithm. Proving cosegregation in families for novel variants and identifying affected females and males translates to optimised clinical care and potential for gene therapy.
Mortality after spinal fusion in children with cerebral palsy and cerebral‐palsy‐like conditions: A 30‐year follow‐up study
Authors: Hariharan Arun , Sees Julieanne P. , Pargas Carlos , Rogers Kenneth J. , Niiler Tim , Shrader Michael Wade , Miller Freeman 
Published: March 2023

AbstractAimTo report survival probability of a large cohort of children with cerebral palsy (CP) after spinal fusion.MethodAll children with CP who had spinal fusion between 1988 and 2018 at the reporting facility were reviewed for survival. Death records of the institutional CP database, institutional electronic medical records, publicly available obituaries, and the National Death Index through the US Centers for Disease Control were searched. Survival probabilities with different surgical eras, comorbidities, ages, and curve severities were compared using Kaplan–Meier curves.ResultsA total of 787 children (402 females, 385 males) had spinal fusion at a mean age of 14 years 1 month (standard deviation 3 years 2 months). The 30‐year estimated survival was approximately 30%. Survival decreased for children who had spinal fusion at younger ages, longer postoperative hospital stays, longer postoperative intensive care unit stays, gastrostomy tubes, and pulmonary comorbidities.InterpretationChildren with CP who required spinal fusions had reduced long‐term survival compared with an age‐matched typically developing cohort; however, a substantial number survived 20 to 30 years after the surgery. This study had no comparison group of children with CP scoliosis; therefore, we do not know whether correction of scoliosis affected their survival.