bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freehand Apple-peeling Technique for Recycled Skin Graft Harvesting in a Case of Buttock Hidradenitis Suppurativa
Authors: Ho Chen-Yu , Lin Keng-Yu , Huang Shu-Hung 
Published: January 2025

Summary:
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder that often necessitates extensive surgery when medical treatment fails, particularly in advanced stages. Traditional surgical approaches, including flaps and skin grafts, are effective for tissue coverage but can lead to vascular complications and recurrence of HS. This study introduces a novel technique, the apple-peeling procedure, combined with negative pressure wound therapy at −50 mm Hg for 5 days postoperatively. This approach demonstrated improved operative efficiency and a low complication rate. Over a 3-year follow-up, there were no signs of HS recurrence, and the patient exhibited satisfactory functional and cosmetic outcomes. This technique may offer a promising alternative for treating HS, reducing the need for additional donor sites and mitigating the risks associated with conventional methods.
Ibrutinib pharmacokinetics in B-lymphoproliferative disorders discloses exposure-related incidence of hypertension
Authors: Ysebaert Loïc , Protin Caroline , Obéric Lucie , Beziat Guillaume , De Barros Sandra , Bonneau Baptiste , Allal Ben , Yakoubi Malika , Quillet-Mary Anne , Despas Fabien 
Published: January 2025

Objective:
Ibrutinib has been the first Bruton tyrosine kinase inhibitor (BTKi) authorized for the treatment of B-cell lymphoproliferative disorders (B-LPDs). Numerous publications have confirmed the efficacy of this orally administrated drug in chemo-free regimens for B-LPDs. They also reported several adverse events (AE) associated with ibrutinib treatment. Whether these AEs depended on ibrutinib exposure has however been seldom explored.

Methods:
In the study reported here, the incidence of AE was recorded in 92 patients with B-LPD (mostly chronic lymphocytic leukemia n = 79) for whom ibrutinib alone was proposed as fist line therapy. Moreover, a pharmacokinetics (PK) exploration was planned over one day after 1 month treatment. PK assays included drug and metabolite (DHD-ibrutinib) mean/median and maximal plasmatic concentrations as well as areas under the curve (AUE) data.

Results:
This PK evaluation was analyzed regarding AEs recorded over the first year of therapy, which were similar as in published reports. PK data disclosed a significant impact of ibrutinib exposure on infections but mostly on the occurrence of hypertension. The latter was mostly related to dihydrodiol-ibrutinib (DHD-ibrutinib) exposure.

Conclusions:
These data suggest that a DHD-ibrutinib assay after one month of treatment could be interesting to consider a lower dosage for patients above maximal concentration thresholds for the drug, its metabolite or the sum of both. Whether this can be applied to newer BTKi remains to be explored but it could be important for patients to whom ibrutinib is proposed.
SMILE-Derived Corneal Stromal Lenticule: Experimental Study as a Corneal Repair Material and Drug Carrier
Authors: Wang Qin , Rao Jing , Zhang Min , Zhou Ling , Chen Xiao , Ma Yanran , Guo Hongjian , Gu Jianing , Wang Yini , Zhou Qizhi 
Published: January 2025

Purpose:
A detailed study of the physicochemical properties of SMILE-derived lenticules and evaluation of their drug delivery after loading with silver nanoparticles (AgNPs).

Methods:
The lenticules were decellularized and modified with crosslinking concentrations of 0.01 (0.01E/L), 0.05 (0.05E/L), and 0.25 (0.25E/L) mmol N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) per mg lenticule at 5:1 carbodiimide/N-hydroxysuccinimide (EDC/NHS) ratios. The degree of swelling, light transmittance, biomechanical properties, and stability of the non-crosslinked decellularized lenticules (DLs), 0.01E/L, 0.05E/L, and 0.25E/L were measured and characterized using Fourier transform infrared spectroscopy and transmission electron microscopy with non-crosslinked non-decellularized lenticules as controls. DLs, 0.01E/L, 0.05E/L, and 0.25E/L were soaked in AgNPs for 24 hours, and the concentration of the drug released was measured.

Results:
There was no significant difference in the degree of swelling between the groups (P > 0.05). The light transmittance of the lenticules did not change after decellularization and crosslinking and decreased after loading with AgNPs. Non-decellularized lenticules biodegraded within 108 to 120 hours, and the other groups biodegraded within 96 to 108 hours in vitro. The 0.01E/L had the highest tensile strength. The absorption peak intensity ratio of the amide I band and the amide II band decreased, and the arrangement of collagen fibers was more compact in crosslinked decellularized lenticules. The 0.01E/L had the highest cumulative drug release (3.4 ± 0.91 μg).

Conclusions:
Crosslinking decellularization improved the biomechanical properties and resistance to water absorption of lenticules, increased covalent bonds between collagen fibers, and improved drug delivery. Crosslinked decellularized lenticules can be used as a new corneal patch material and drug delivery carrier for drug AgNPs.
Keratorefractive Lenticule Extraction: Early Postoperative Day 1 Outcomes in 1350 Consecutive Procedures
Authors: Pradhan Kishore Raj , Arba Mosquera Samuel 
Published: January 2025

Purpose:
To evaluate postoperative visual outcomes on postoperative day 1 (POD1) after lenticule extraction in myopia astigmatism in a large cohort of over 1350 consecutive treatments.

Methods:
A retrospective review chart identified 1357 eyes consecutively treated with SCHWIND ATOS using lenticule extraction for myopic astigmatism who had at least 6 months of follow-up completed and for which POD1 was completely recorded. The standard visual and refractive outcomes, and astigmatism outcomes, were analyzed on POD1. As a sanity check, the stability of defocus and uncorrected distance visual acuity (UDVA) were evaluated from day 1 to 1-year postoperative follow-ups.

Results:
On POD1, 82% of the eyes achieved an UDVA of 20/20 or better, with 82% of the eyes with postoperative UDVA being the same or better than the preoperative corrected distance visual acuity baseline, and only 2% of eyes lost 2 lines of corrected distance visual acuity. Postoperative spherical equivalent (+0.15 ± 0.35D) was within 0.75 D in 98% of the cases, with excellent stability from 1-week to 1-year postoperative follow-ups (11% eyes changing by 0.5D of defocus). Postoperative refractive astigmatism at POD1 (0.01 ± 0.08 D) was highly accurate, with over 99% of the cases within 0.5 D, and 99% within 5 degrees of the attempted axis. The astigmatic correction index (1.00 ± 0.08) showed 98% of the cases within 10% deviation.

Conclusions:
In this large cohort of over 1350 cases, lenticule extraction using SCHWIND ATOS is safe and effective on POD1, shows stability from 1-week to 1-year postoperative follow-ups, and suggests accurate and precise corrections for both defocus and astigmatism.
“I Look in the Mirror and Say ‘You Know What, There Is Hope for You’”—An Interpretative Qualitative Study of Current and Future Well-Being in Black African Women Older Than 50 Years With HIV in the United Kingdom
Authors: Conway Rebecca , Evangeli Michael , Namiba Angelina , Jones Rachael 
Published: January 2025

Abstract
Effective antiretroviral treatment means that people with HIV are living for longer. This includes Black African women, who represent a large proportion of people aging with HIV in the United Kingdom. Despite this, the impact of living and aging with HIV on the well-being of Black African women aging with HIV has not been investigated. Interpretative phenomenological analysis of interviews with eight Black African women ages 50 years and older living with HIV developed six superordinate themes. Findings demonstrated how experiences of HIV-related stigma negatively affected social, occupational, and psychological well-being. Perspectives on living and aging with HIV into the future included experiences of acceptance, uncertainty, anxiety, and hope. Recommendations are made, including developing clinical practice to consider needs relating to social and psychological well-being, as well as physical well-being, for women aging with HIV.
The Relationship Between Subjective Cognitive Complaints, Invalid Symptom Reporting, and Neurocognitive Test Performance Validity Among Adults Being Evaluated for ADHD
Authors: Phillips Matthew S. , Turchmanovych-Hienkel Nataliya , Leese Mira I. , Ramanauskas Brian , VanLandingham Hannah B. , Gonzalez Christopher , Ovsiew Gabriel P. , Robinson Anthony D. , Cerny Brian M. , Ulrich Devin M. , Soble Jason R. 
Published: January 2025

Objective:
Subjective cognitive complaints are common among patients presenting for evaluation of attention-deficit/hyperactivity disorder (ADHD). Despite these complaints, research overwhelmingly suggests that reported cognitive deficits do not align with objective neurocognitive performance. This study explored the relationship between subjective cognitive complaints, objective neuropsychological functioning, and performance and symptom validity testing in adult patients referred for evaluation due to concern about ADHD.

Methods:
The sample consisted of 523 adult referrals who underwent comprehensive evaluation for concern about ADHD and to characterize cognitive strengths and weaknesses. Four hundred patients were diagnosed with ADHD, and 123 did not meet the diagnostic criteria for ADHD. Patients were dichotomized to form nonelevated (n=134) and elevated (n=389) cognitive complaint groups, which were compared on objective neurocognitive performance, report of ADHD-specific symptoms, and performance validity tests.

Results:
Significant differences were identified between the elevated and nonelevated cognitive complaints groups in performance validity tests and ADHD symptom reporting; however, clinical differences were not identified on objective neurocognitive measures.

Conclusions:
Consistent with the results of previously published research, subjective cognitive complaints did not align with objective neurocognitive deficits in a sample of adult ADHD referrals. Elevated cognitive complaints were associated with higher rates of performance validity failure and invalid ADHD-specific symptom reporting. These findings highlight the importance of assessing cognitive complaints using symptom report inventories and cognitive tests that include objective validity indices.
The Evaluation of the Pterygomaxillary Separation Pattern in Le Fort I Osteotomy Using Cone Beam Computed Tomography
Authors: Faisal Mustafa M. , Bede Salwan Y. 
Published: January 2025

Pterygomaxillary separation (PMS) is an important step in Le Fort I osteotomy procedure, without which complete mobilization of the maxilla cannot be achieved. The aim of this study was to evaluate PMS patterns and their relationship with the anatomic measurements in Le Fort I osteotomy. In this prospective observational study cone beam computed tomography (CBCT) was used to measure the anatomic variables of the pterygomaxillary junction (PMJ) region including thickness, width, the distance between the most concave point at the lateral surface of PMJ and the greater palatine foramen (C-GPF), and the angle preoperatively, and the separation patterns postoperatively divided into the clean-cut type, maxillary sinus type, and the pterygoid fracture type. Twenty-seven patients (54 sides) were included in this study. Nineteen females (70.4%) and 8 males (29.6%) with a mean (standard deviation) of 22.1 (5.5) years. The mean PMJ thickness, width, C-GPF, and angle were 5.6 mm, 8.6 mm, 6.55 mm, and 91.5 degrees, respectively. The most common PMS pattern was the clean-cut type (38/54, 70.4%), followed by the pterygoid plate fracture type (10/54, 18.5%), and the maxillary sinus type (6/54, 11.1%). There were non-significant relationships between the anatomic variables of PMJ and PMS patterns (thickness P=0.179, width P=0.234, C-GPF P=0.174, and angle P=0.792). There were non-significant relationships between PMS patterns and age, sex, and skeletal classification of the patients (P= 0.941, 0.211, and 0.519, respectively).
Predictive model for the determination of caesarean sections in the Catalan National Health System: an approach based on clinical factors
Authors: Medina Català Albert , Espada-Trespalacios Xavier , Raventos Gil de Biedma Maria , Ricart Conesa Assumpta , Palau-Costafreda Roser , Escuriet Ramon 
Published: January 2025

ABSTRACTObjectiveTo develop and validate a logistic regression model for analyzing the probability of caesarean section births, adjusted for clinical complexity, across public hospitals in Catalonia, and to identify deviations from expected caesarian section rates for benchmarking and quality improvement.MethodsThis retrospective cohort study analyzed data from the Catalan National Health System’s Minimum Basic Data Set (CMBD-AH), including all deliveries in public hospitals from January 2018 to June 2024. A logistic regression model was constructed using maternal and obstetric factors such as age, obstetric history, and clinical conditions. The model was validated through calibration plots and receiver operating characteristic (ROC) curve analysis, achieving an area under the curve (AUC) of 0.803.ResultsThe analysis revealed variability in observed-to-expected caesarean section ratios across hospital complexity levels. Level III hospitals aligned closely with expected rates, reflecting adherence to clinical standards for high-complexity cases. Level I hospitals demonstrated significant variability, with 59.1% performing more cesareans than expected; smaller hospitals with fewer than 1,000 births exhibited the greatest deviation. The model highlighted both underperforming and overperforming institutions, offering actionable insights for resource allocation and policy interventions.ConclusionsThe logistic regression model provides a robust framework for evaluating caesarean section practices, enabling fair comparisons between hospitals by adjusting for clinical complexity. It supports the identification of non-clinical factors influencing cesarean practices and offers a critical tool for quality improvement and optimizing maternal healthcare within Catalonia’s public health system.
CPI-Pred: A deep learning framework for predicting functional parameters of compound-protein interactions
Authors: Xu Zhiqing , Barghout Rana Ahmed , Wu Jinghao , Garg Dhruv , Song Yun S. , Mahadevan Radhakrishnan 
Published: January 2025

AbstractRecent advancements in deep learning have enabled functional annotation of genome sequences, facilitating the discovery of new enzymes and metabolites. However, accurately predicting compound-protein interactions (CPI) from sequences remains challenging due to the complexity of these interactions and the sparsity and heterogeneity of available data, which constrain the generalization of patterns across their solution space. In this work, we introduce CPI-Pred, a versatile deep learning model designed to predict compound-protein interaction function. CPI-Pred integrates compound representations derived from a novel message-passing neural network and enzyme representations generated by state-of-the-art protein language models, leveraging innovative sequence pooling and cross-attention mechanisms. To train and evaluate CPI-Pred, we compiled the largest dataset of enzyme kinetic parameters to date, encompassing four key metrics: the Michaelis-Menten constant (KM), enzyme turnover number (kcat), catalytic efficiency (kcat/KM), and inhibition constant (KI).These kinetic parameters are critical for elucidating enzyme function in metabolic contexts and understanding their regulation by compounds within biological networks. We demonstrate that CPI-Pred can predict diverse types of CPI using only the amino acid sequence of enzymes and structural representations of compounds, outperforming state-of-the-art models on unseen compounds and structurally dissimilar enzymes. Over workflow provides a valuable tool for tackling a range of metabolic engineering challenges, including the designing of novel enzyme sequences and compounds, such as enzyme inhibitors. Additionally, the datasets curated in this study offer a valuable resource for the scientific community, serving as a benchmark for machine learning models focused on enzyme activity and promiscuity prediction.
Accounting for comorbidity in etiological research
Authors: Khachadourian Vahe , Janecka Magdalena 
Published: January 2025

ABSTRACTIntroductionDespite the theoretical advancements and recommendations regarding covariate adjustment in causal inference, clinical studies often fail to explicitly state the underlying assumptions related to causal structure among the study variables. Specifically, despite the pervasive nature of comorbidity, explicit causal assumptions about the role of comorbidity in exposure-outcome relationships are often lacking, potentially leading to inappropriate accounting for comorbid conditions and resulting in biased effect estimates. This study aims to explore common causal structures involving comorbidity and provide guidance for handling it in etiologic research.MethodsWe use Directed Acyclic Graphs (DAGs) to depict six causal scenarios involving comorbidity as a confounder, mediator, collider, or consequence of the exposure or outcome. Simulations were conducted across 5,000 iterations for each scenario, assessing the impact of conditioning on comorbidity under three effect measures (mean difference, odds ratio, risk ratio). Bias was evaluated by comparing adjusted and unadjusted effect estimates to the true values.ResultsThe impact of conditioning on comorbidity varied by its causal role. Adjusting for comorbidity mitigated bias when it acted as a confounder, but introduced bias when it was a mediator or collider. In instances where comorbidity was a consequence of either the exposure or outcome, the decision to adjust depended on the research objectives. Nonlinear models revealed differences in marginal and conditional effects due to non-collapsibility.DiscussionExplicit causal assumptions are essential for selecting appropriate analytical strategies in etiologic research. This study provides practical guidance on handling comorbidity-related challenges, highlighting the need for study design and analysis to align with research objectives. Future work should address more complex causal structures and other methodological challenges.
Density-dependent expression of epitranscriptomic, stress, and appetite regulating genes in Atlantic salmon
Authors: Frapin Morgane , Quispe Laura , Troka Joana , Prokkola Jenni M. , Laurikainen Ossi , Hyvärinen Pekka , Primmer Craig R. , Aykanat Tutku , Ahi Ehsan Pashay 
Published: January 2025

AbstractIntraspecific competition due to e.g., density, has substantial influence on fitness dynamics and life histories, but the underlying physiological mechanisms are often complex, and the molecular basis unclear. Further, designing laboratory experiments to measure physiological responses that reflect natural conditions is challenging. Here, we reared Atlantic salmon juveniles in semi-wild conditions in two naturally occurring densities to investigate the molecular mechanism of density-related changes in the hypothalamus, a key brain region regulating stress and energy homeostasis. We measured density-dependent changes in the expression of 12 genes involved in appetite and stress regulation, and 16 genes involved in post-transcriptional regulation of gene expression via m6A RNA methylation. This gene set includes paralog pairs, to account for potential functional divergence associated with salmonid genome duplication. We also quantified genotype-environment interactions between density and two major life-history loci,vgll3andsix6. We found significant density-related differences in the expression of genes coding for corticotropin-releasing factors, appetite stimulators and inhibitors, and m6A RNA methylation actors. Moreover, a paralogue of an appetite inhibitor showed a density-dependent pattern that was the opposite of what was expected.Six6locus was also associated with changes in the expression of epitranscriptomic markers, including two writers and one eraser. Our results highlight that individuals’ response to density in natural conditions is shaped by a complex interplay between stress, appetite and epitranscriptomic pathways in the hypothalamus. In addition, the functional divergence of paralogs indicates a potential role of genome duplication shaping such a response. We emphasize the value of integrating different physiological responses at the molecular level to better understand ecological processes affected by environmental change.
Barriers and facilitators to specialist service referrals for sleep disorders from healthcare professionals’ perspective: A scoping review of qualitative research evidence
Authors: Sýkorová Martina , Nolte Ellen , Martineau Frederick , Miller Michelle A. , Eriksson Sofia H. , Smith Ian E. , Strongman Helen 
Published: January 2025

AbstractBackgroundAccess to specialist sleep centres can lead to timely diagnosis and management of sleep disorders, improving the health and quality of life of people with these conditions. Evidence describing factors that influence referral to specialist sleep services is needed to inform improvements to the referral process.ObjectiveThis scoping review identifies and summarises qualitative evidence on barriers and facilitators to referrals to specialist sleep services by healthcare professionals.Eligibility criteriaThe review considered qualitative studies published in any language between 1995-2024 that explore the barriers and/or facilitators to referral to specialist services for sleep-related disorders from healthcare care professionals’ perspective.Sources of evidenceA systematic search of six databases (Cochrane Library, MEDLINE, PubMed, Scopus, EMBASE and Open Grey) was conducted.ResultsOut of 3507 records, seven heterogeneous studies from two countries (Australia and USA) and one multi-country study met the inclusion criteria. Referrals were from a range of settings including primary care (two studies). Major themes identified as influencing referral included clarity of roles, referral experiences and options, knowledge of sleep disorders, funding, and views on treatment. Specific barriers and facilitators varied between countries, healthcare professionals and sleep disorders.ConclusionsAlthough specific barriers and facilitators vary between settings, cross-cutting themes influencing referral to sleep centres reflect a lack of awareness of sleep disorders among healthcare professionals, poorly defined referral pathways, and funding issues.ImpactsThis is the first scoping review to synthesise qualitative evidence on factors influencing referrals to specialist services for sleep disorders. The themes identified can be used in further research to inform improvements to referral pathways in different settings.Reporting MethodAdherence to the PRISMA-ScR checklist was maintained.