bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating post-mild traumatic brain injury neuromuscular function and musculoskeletal injury risk: A protocol for a prospective, observational, case–controlled study in service members and active individuals
Authors: Lynall Robert C , Wasser Joseph G , Brooks Daniel I , Call Jarrod A , Hendershot Brad D , Kardouni Joseph R , Schmidt Julianne D , Mauntel Timothy C 
Published: May 2023

IntroductionMusculoskeletal injury (MSKI) risk is increased following mild traumatic brain injury (mTBI). Increased MSKI risk is present up to 2 years following post-mTBI return-to-duty/activity relative to both non-mTBI peers and to their pre-mTBI selves across a range of populations, including military service members, and professional, college and high school athletes. Despite the well documented increased post-mTBI MSKI risk, the underlying neuromuscular mechanisms contributing to this increased risk have yet to be definitively determined. A number of potential mechanisms have been suggested (eg, aberrant kinematics, dynamic balance impairments, lower voluntary muscle activation), but none have been confirmed with a comprehensive, prospective study. This study aims to: (1) elucidate the neuromuscular control mechanisms following mTBI that contribute to increased MSKI risk, and (2) prospectively track patient outcomes (up to 12 months; MSKI occurrences and patient-reported outcomes (PRO)).Methods and analysisThis is a multicentre prospective, case-matched control observational study to identify deficiencies in neuromuscular function following mTBI that may contribute to increased MSKI risk. Participants (aim to recruit 148, complete data collection on 124) will be classified into two cohorts; mTBI and control. All participants will undergo longitudinal (initial, 6 weeks post-initial, 12 weeks post-initial) comprehensive three-dimensional biomechanical (jump-landing; single leg hop; cut; gait), neuromuscular (interpolated twitch technique, muscular ramp contraction) and sensory (joint repositioning; light touch sensation) assessments to elucidate the underlying neuromuscular control mechanisms post-mTBI that may contribute to increased MSKI. Occurrences of MSKI and PROs (National Institutes of Health Patient-Reported Outcome Measurement Information System: Physical Function, Pain Interference, Depression, Anxiety; Brief Resilience Scale; Tampa Scale of Kinesiophobia), will be tracked monthly (up to 1 year) via electronic data capture platforms.Ethics and disseminationThe study received approval from the Walter Reed National Military Medical Center Institutional Review Board. Results will be made available to the associated funding agency and other researchers via conference proceedings and journal articles.Trial registration numberNCT05122728.
Cash plus programming and intimate partner violence: a qualitative evaluation of the benefits of group-based platforms for delivering activities in support of the Ethiopian government’s Productive Safety Net Programme (PSNP)
Authors: Buller Ana Maria , Pichon Marjorie , Hidrobo Melissa , Mulford Michael , Amare Tseday , Sintayehu Wastina , Tadesse Seifu , Ranganathan Meghna 
Published: May 2023

ObjectivesIntimate partner violence (IPV) is a public health challenge but there is evidence that cash and cash ‘plus’ interventions reduce IPV. An increasingly popular design feature of these kind of interventions is the group-based modality for delivering plus activities, however, evidence of the mechanisms through which this modality of delivery impacts IPV is limited. We explore how the group-based modality of delivering plus activities that complemented the Government of Ethiopia’s Productive Safety Net Programme contributed to modifying intermediate outcomes on the pathway to IPV.DesignQualitative study using in-depth interviews and focus group discussions between February and March 2020. Data were analysed using a thematic content and gender lens approach. Findings were interpreted, refined and drafted in collaboration with our local research partners.SettingAmhara and Oromia regions in Ethiopia.ParticipantsIn total 115 men and women beneficiaries from the Strengthen PSNP4 Institutions and Resilience (SPIR) programme took part in the study. Fifty-eight were interviewed and 57 took part in 7 focus group discussions.ResultsWe found that Village Economic and Social Associations—through which SPIR activities were delivered—improved financial security and increased economic resilience against income shocks. The group-based delivery of plus activities to couples appeared to enhance individual agency, collective power and social networks, which in turn strengthened social support, gender relations and joint decision-making. Critical reflective dialogues provided a reference group to support the shift away from social norms that condone IPV. Finally, there appeared to be gender differences, with men highlighting the financial benefits and enhanced social status afforded by the groups, whereas women’s accounts focused primarily on strengthened social networks and social capital.ConclusionOur study offers important insights into the mechanisms by which the group-based delivery of plus activities affects intermediate outcomes on the pathway to IPV. It underscores the importance of the modality of delivery in such programmes, and suggests that policy-makers should consider gender-specific needs as men and women might differentially benefit from interventions that enhance social capital to generate gender transformative impacts.
Clinical features and novel technologies for prehospital detection of intracerebral haemorrhage: a scoping review protocol
Authors: Almubayyidh Mohammed , Alghamdi Ibrahim , Parry-Jones Adrian Robert , Jenkins David 
Published: May 2023

IntroductionThe detection of intracerebral haemorrhage (ICH) in the prehospital setting without conventional imaging technology might allow early treatment to reduce haematoma expansion and improve patient outcomes. Although ICH and ischaemic stroke share many clinical features, some may help in distinguishing ICH from other suspected stroke patients. In combination with clinical features, novel technologies may improve diagnosis further. This scoping review aims to first identify the early, distinguishing clinical features of ICH and then identify novel portable technologies that may enhance differentiation of ICH from other suspected strokes. Where appropriate and feasible, meta-analyses will be performed.MethodsThe scoping review will follow the recommendations of the Joanna Briggs Institute Methodology for Scoping Reviews as well as the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. A systematic search will be conducted using MEDLINE (Ovid), EMBASE (Ovid) and CENTRAL (Ovid). EndNote reference management software will be used to remove duplicate entries. Two independent reviewers will screen titles, abstracts and full-text reports according to prespecified eligibility criteria using the Rayyan Qatar Computing Research Institute software. One reviewer will screen all titles, abstracts and full-text reports of potentially eligible studies, while the other reviewer will independently screen at least 20% of all titles, abstracts and full-text reports. Conflicts will be resolved through discussion or by consulting a third reviewer. Results will be tabulated in accordance with the scoping review’s objectives along with a narrative discussion.Ethics and disseminationEthical approval is not required for this review, as it will only include published literature. The results will be published in an open-access, peer-reviewed journal, presented at scientific conferences and form part of a PhD thesis. We expect the findings to contribute to future research into the early detection of ICH in suspected stroke patients.
Impact of prestroke physical activity and citalopram treatment on poststroke depressive symptoms: a secondary analysis of data from the TALOS randomised controlled trial in Denmark
Authors: Vestergaard Sigrid Breinholt , Damsbo Andreas Gammelgaard , Blauenfeldt Rolf Ankerlund , Johnsen Søren Paaske , Andersen Grethe , Mortensen Janne Kaergaard 
Published: May 2023

ObjectivesTo investigate the association between prestroke physical activity and depressive symptoms up to 6 months after stroke and examine if citalopram treatment modified the association.DesignA secondary analysis of data from the multicentre randomised controlled trial The Efficacy of Citalopram Treatment in Acute Ischemic Stroke (TALOS).Setting and participantsTALOS was conducted at multiple stroke centres in Denmark from 2013 to 2016. It enrolled 642 non-depressed patients with first-ever acute ischaemic stroke. Patients were eligible for this study if a prestroke physical activity level was assessed by the Physical Activity Scale for the Elderly (PASE).InterventionsAll patients were randomised to citalopram or placebo for 6 months.OutcomesDepressive symptoms 1 and 6 months after stroke measured on the Major Depression Inventory (MDI) ranging from 0 to 50.ResultsA total of 625 patients were included. Median (IQR) age was 69 (60–77) years, 410 (65.6%) were men, 309 (49.4 %) received citalopram and median (IQR) prestroke PASE score was 132.5 (76–197). Higher prestroke PASE quartile, compared with the lowest PASE quartile, was associated with fewer depressive symptoms both after 1 month (mean difference third quartile −2.3 (−4.2, –0.5), p=0.013, mean difference fourth quartile −2.4 (−4.3, –0.5), p=0.015) and 6 months after stroke (mean difference third quartile −3.3 (−5.5, –1.2), p=0.002, mean difference fourth quartile −2.8 (−5.2, –0.3), p=0.027). There was no interaction between citalopram treatment and prestroke PASE score on poststroke MDI scores (p=0.86).ConclusionsA higher prestroke physical activity level was associated with fewer depressive symptoms 1 and 6 months after stroke. Citalopram treatment did not seem to modify this association.Trial registration numbersNCT01937182(ClinicalTrials.gov) and 2013-002253-30 (EUDRACT).
Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma
Authors: Corradi Chiara , Lencioni Giulia , Gentiluomo Manuel , Felici Alessio , Latiano Anna , Kiudelis Gediminas , van Eijck Casper H J , Marta Katalin , Lawlor Rita T , Tavano Francesca , Boggi Ugo , Dijk Frederike , Cavestro Giulia Martina , Vermeulen Roel C H , Hackert Thilo , Petrone Maria Chiara , Uzunoğlu Faik Güntac , Archibugi Livia , Izbicki Jakob R , Morelli Luca , Zerbi Alessandro , Landi Stefano , Stocker Hannah , Talar-Wojnarowska Renata , Di Franco Gregorio , Hegyi Péter , Sperti Cosimo , Carrara Silvia , Capurso Gabriele , Gazouli Maria , Brenner Hermann , Bunduc Stefania , Busch Olivier , Perri Francesco , Oliverius Martin , Hegyi Péter Jeno , Goetz Mara , Scognamiglio Pasquale , Mambrini Andrea , Arcidiacono Paolo Giorgio , Kreivenaite Edita , Kupcinskas Juozas , Hussein Tamas , Ermini Stefano , Milanetto Anna Caterina , Vodicka Pavel , Kiudelis Vytautas , Hlaváč Viktor , Soucek Pavel , Theodoropoulos George E , Basso Daniela , Neoptolemos John P , Nóbrega Aoki Mateus , Pezzilli Raffaele , Pasquali Claudio , Chammas Roger , Testoni Sabrina Gloria Giulia , Mohelnikova-Duchonova Beatrice , Lucchesi Maurizio , Rizzato Cosmeri , Canzian Federico , Campa Daniele 
Published: May 2023

IntroductionOnly a small number of risk factors for pancreatic ductal adenocarcinoma (PDAC) has been established. Several studies identified a role of epigenetics and of deregulation of DNA methylation. DNA methylation is variable across a lifetime and in different tissues; nevertheless, its levels can be regulated by genetic variants like methylation quantitative trait loci (mQTLs), which can be used as a surrogate.Materials and methodsWe scanned the whole genome for mQTLs and performed an association study in 14 705 PDAC cases and 246 921 controls. The methylation data were obtained from whole blood and pancreatic cancer tissue through online databases. We used the Pancreatic Cancer Cohort Consortium and the Pancreatic Cancer Case–Control Consortium genome-wide association study (GWAS) data as discovery phase and the Pancreatic Disease Research consortium, the FinnGen project and the Japan Pancreatic Cancer Research consortium GWAS as replication phase.ResultsThe C allele of 15q26.1-rs12905855 showed an association with a decreased risk of PDAC (OR=0.90, 95% CI 0.87 to 0.94, p=4.93×10−8in the overall meta-analysis), reaching genome-level statistical significance. 15q26.1-rs12905855 decreases the methylation of a 'C-phosphate-G' (CpG) site located in the promoter region of theRCCD1antisense (RCCD1-AS1) gene which, when expressed, decreases the expression of the RCC1 domain-containing (RCCD1) gene (part of a histone demethylase complex). Thus, it is possible that the rs12905855 C-allele has a protective role in PDAC development through an increase ofRCCD1gene expression, made possible by the inactivity ofRCCD1-AS1.ConclusionWe identified a novel PDAC risk locus which modulates cancer risk by controlling gene expression through DNA methylation.
Cripping the pain scale: literary and biomedical narratives of pain assessment
Authors: Mellor Neko 
Published: May 2023

This article analyses the literary representation of pain scales and assessment in two chronic pain narratives: ‘The Pain Scale’, a lyric essay by Eula Biss, and essays from Sonya Huber’s collectionPain Woman Takes Your Keys, and Other Essays from a Nervous System. Establishing first a brief history of methods attempting to quantify pain before my close reading, I read both Biss’ and Huber’s accounts as performative explorations of the limitations of using linear pain scales for pain which is recursive and enduring. Considering both texts as cripistemologies of chronic pain, my literary analysis attends to their criticism of the pain scale, including its implicit reliance on imagination and memory, and how its unidimensionality and synchronic focus prove inadequate for lasting pain. For Biss, this surfaces as a quiet critique of numbers and a disturbance of their fixity, while Huber’s criticism employs the motif of pain’s legibility across multiple bodies to spell out alternative meanings of chronic pain.Crucially, this article proposes a crip and embodied approach for reading and responding to accounts of chronic pain’s measurement, including Biss’ and Huber’s literary accounts, and the biomedical account of pains scales which this article reads alongside them. The article’s analysis draws on my personal experience of chronic pain, neurodivergence and disability to demonstrate the generativity of an embodied approach to literary analysis. Rather than bowing to the impulse to impose false coherence on my reading of Biss and Huber, my article foregrounds the impact of the re-reading, misreading, cognitive dissonance and breaks necessitated by chronic pain and processing delays on this analysis. In bringing an ostensibly crip methodology to bear on readings of chronic pain, I hope to invigorate discussions on reading, writing and knowing chronic pain in the critical medical humanities.
β-Catenin–Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer
Authors: Mohan Dipika R. , Borges Kleiton S. , Finco Isabella , LaPensee Christopher R. , Rege Juilee , Solon April L. , Little Donald W. , Else Tobias , Almeida Madson Q. , Dang Derek , Haggerty-Skeans James , Apfelbaum April A. , Vinco Michelle , Wakamatsu Alda , Mariani Beatriz M.P. , Amorim Larissa Costa , Latronico Ana Claudia , Mendonca Berenice B. , Zerbini Maria Claudia N. , Lawlor Elizabeth R. , Ohi Ryoma , Auchus Richard J. , Rainey William E. , Marie Suely K.N. , Giordano Thomas J. , Venneti Sriram , Fragoso Maria Candida Barisson Villares , Breault David T. , Lerario Antonio Marcondes , Hammer Gary D. 
Published: May 2023

Abstract

Adrenocortical carcinoma (ACC) is a rare cancer in which tissue-specific differentiation is paradoxically associated with dismal outcomes. The differentiated ACC subtype CIMP-high is prevalent, incurable, and routinely fatal. CIMP-high ACC possess abnormal DNA methylation and frequent β-catenin–activating mutations. Here, we demonstrated that ACC differentiation is maintained by a balance between nuclear, tissue-specific β-catenin–containing complexes, and the epigenome. On chromatin, β-catenin bound master adrenal transcription factor SF1 and hijacked the adrenocortical super-enhancer landscape to maintain differentiation in CIMP-high ACC; off chromatin, β-catenin bound histone methyltransferase EZH2. SF1/β-catenin and EZH2/β-catenin complexes present in normal adrenals persisted through all phases of ACC evolution. Pharmacologic EZH2 inhibition in CIMP-high ACC expelled SF1/β-catenin from chromatin and favored EZH2/β-catenin assembly, erasing differentiation and restraining cancer growth in vitro and in vivo. These studies illustrate how tissue-specific programs shape oncogene selection, surreptitiously encoding targetable therapeutic vulnerabilities.

Significance:
Oncogenic β-catenin can use tissue-specific partners to regulate cellular differentiation programs that can be reversed by epigenetic therapies, identifying epigenetic control of differentiation as a viable target for β-catenin–driven cancers.
Coenesthesia or the Immediate Feeling of Existence: Maine de Biran and the Problem of the Unconscious between Physiology and Philosophy
Authors: Aloisi Alessandra 
Published: May 2023

Abstract
The term “coenesthesia” was introduced at the end of the eighteenth century by the German physiologist Johann Christian Reil to designate the general perception of the living body through the nerves. Over the course of the nineteenth century, this notion circulated widely not only in Germany, but also in France, where it was developed in particular by Théodule Ribot. However, a good sixty years before Ribot, Maine de Biran had already employed the notion of “coenesthesia” to indicate the “immediate feeling of existence,” which he distinguished from the apperception of the self in relation to the body. What Biran emphasized, in his philosophical appropriation of “coenesthesia,” is the impersonal and mostly unconscious nature of this feeling, which never leaves us and plays a key role in the shaping of our personal and conscious life, unnoticeably influencing the course of our ideas, our character, and the emotional tone of our perception of the world. The purpose of this article is to study Biran’s philosophical use of the notion of “coenesthesia” in the last phase of his philosophical reflection (1823–1824) in relation to the emergence of the problem of the unconscious.
Pierre Janet: A Psychological Reading of Maine De Biran’s Theory of the Unconscious
Authors: Vincenti Denise 
Published: May 2023

Abstract
This paper aims to analyze Pierre Janet’s interpretation of Maine de Biran’s notion of the “unconscious” through a comparative study between L’automatisme psychologique (1889) and some Biranian writings devoted to the problem of pure affections. The objective is to question whether Janet’s psychological reading of this very notion had been faithful to Biran’s intentions, and to understand what kind of Biranism Janet is referring to when dealing with the problem of the unconscious.
Model of Transnational Online Serial Sociocultural Lectures for Overseas Chinese Children and Its Evaluation
Authors: Yang Zhiling 
Published: May 2023

Abstract
Previous lectures targeted at overseas Chinese children have mostly been offline in the form of youth camps sponsored by the Chinese governments before the COVID-19 pandemic and are now usually administered online in a single-topic format transnationally post-pandemic. This form of “one-to-many” singular online lectures comes along with discontinuity, mass audiences, chaos, and being less tailored to the individual needs and context, failing to meet the evaluation metrics in different evaluation levels. This paper proposes a model of transnational online livestreaming serial socio-cultural lectures for overseas Chinese children, which puts forward the synergy of lecturing staff from higher educational institutions (HEIs) in China and students at Chinese language schools (CLSs) worldwide as participants. Lecturing staff from needs and context HEIs can guarantee sufficient keynote speakers for “one-on-one” mode and cope with the above-mentioned problems. After the implementation of five sessions of these serial lectures, evaluation of this model shows that the pre-lecture, during-lecture, and post-lecture stages have are applicable. Furthermore, for sociocultural lectures, the audience may be more interested in literature classics than folk arts from a specific region. Correlation analysis reveals that younger children have a better evaluation of this model and an improved inclination to attend lectures, which sheds light on the improvement of sociocultural lectures as online lectures are preferred among overseas Chinese children.
Mꜣꜥt ‘Maat’, Death and the Afterlife
Authors: Aketema Joseph , Kambon Ọbádélé Bakari 
Published: May 2023

Abstract
This study sets out to demonstrate how in classical and traditional Afrikan thought one’s afterlife on physical and spiritual planes is thought of as being commensurate with one’s adherence to Mꜣꜥt ‘Maat’ in terms of lived practice rather than simply as an abstract ideal. As such, we will interrogate textual examples from classical Kmt ‘The Black Nation/Land of the Blacks’ and attested lived examples from contemporary Afrika among the Kasena-Nankana with brief references to other cultural-linguistic groups. We demonstrate there is a shared understanding from the classical to the contemporary in terms of how one’s body is treated and how one’s experience in the afterlife is conceptualized. We find that conceptions of the afterlife have influenced how Afrikans engage Mꜣꜥt ‘Maat’ as praxis.
Radial growth rate does not affect radial variation of latewood tracheid length in aged trees of Thujopsis dolabrata var. hondae
Authors: Nezu Ikumi , Ishiguri Futoshi , Ohshima Jyunichi , Yokota Shinso 
Published: May 2023

Summary
Tracheid length is lowest at the pith and then it increases rapidly as cambial age increases up until it reaches an asymptote value in what is known as ‘Sanio’s first law’. However, it is still unclear the effect of radial growth rate on latewood tracheid length and the effect of radial variation pattern of latewood tracheid length on the boundary position between juvenile and mature wood in aged trees. Radial variation modeling was applied to annual ring width and latewood tracheid length in aged trees (79–238 years old) of Thujopsis dolabrata var. hondae grown in natural forests and a plantation in Shimokita Peninsula, Aomori, Japan. In addition, the effect of differences in radial variation patterns of latewood tracheid length on the boundary age between juvenile and mature wood was evaluated. Cambial age showing the maximum values of current annual increment and mean annual increment was 42–121 and 65–189 years for natural forests and 30–33 and 46–52 years for the plantation, respectively. A mixed-effects model based on a logarithmic function with an explanatory variable of only cambial age, and random intercepts of stand and individual tree, was selected as the one best explaining the radial variation of latewood tracheid length. The estimated boundary cambial age was approximately 20 years in all trees regardless of radial growth rate. We concluded that (1) the regularity of radial variation in tracheid known as ‘Sanio’s first law’ can be adapted to at least about 250 annual rings from the pith in T. dolabrata trees, (2) the boundary cambial age is similar to that in younger trees, and (3) the effect of radial growth rate on latewood tracheid length is minimal in T. dolabrata.