bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Gender pada Kemampuan Mengenal Angka pada Anak Usia Empat Tahun
Authors: Winda Netri , Mahyuddin Nenny 
Published: December 2022

Kemampuan mengenal angka merupakan dasar pembelajaran matematika. Kesuksesan belajar matematika di masa mendatang dilaporkan dipengaruhi oleh kemampuan ini. Penelitian ini bertujuan untuk mengalisis kemampuan mengenal angka pada anak usia dini. Penelitian ini merupakan penelitian survey yang menggunakan metode pengambilan sampel jenuh. Teknik pengumpulan data yang digunakan lembar observasi. Teknik analisis data yang digunakan pada penelitian ini merupakan analisis data deskripif dan uji t. Berdasarkan hasil penelitian diketahui bahwa kemampuan mengenal angka pada anak berada dalam kategori rendah. Kemudian setelah dilakukan uji t menggunakan independent sample t test diketahui tidak terdapat perbedaan yang signifikan kemampuan mengenal angka anak usia berdasarkan jenis kelamin. Implikasi hasil penelitian ini dapat digunakan sebagai dasar evaluasi bagi guru untuk melakukan variasi metode pembelajaran di kelas
Oral Solid Dosage form Modification in Community Pharmacies of Kavrepalanchok and Bhaktapur Districts of Nepal
Authors: Shrestha J. , Shrestha A. , Shrestha B. , Gamal K. , Manandhar S. , Koju S. , Koju Shrestha R. 
Published: December 2022

Background People may modify their oral solid dosage form of medicine to deal with problem faced during medicine administration. The modification of dosage form may adversely affect the quality, safety and efficacy of the medicine.
Objective To investigate the causes and practices of oral solid dosage form modification among the consumers going to community pharmacies.
Method A descriptive, cross-sectional study was conducted in five community pharmacies of Kavrepalanchok and Bhaktapur districts of Nepal. The consumers visiting these pharmacies for their oral solid dosage form of medicine were invited to participate in interview using structured questionnaire.
Result Among 419 participants,13.6% of participants reported having problem of taking intact medicine. Most of them (12.4% of total participants) experienced difficulty swallowing the medicine. The swallowing difficulty is significantly associated with age and sex (p < 0.05). Around one third (36.8%) of participant with medicine administration problem modified the dosage form of medicines. One quarter of medicine dosage form modifications (25.0%) were inappropriate. Medicine dosage form modification is associated with age and number of daily medicine intake (p < 0.05). Among participants modifying dosage form of medicines, 66.7% were advised to do so mainly by family and friends; 33.3% were modifying on their own and 76.2% were unaware of possible effects of medicine dosage form modification. About 62.3% of total participants were never asked about any problems on taking medicines by doctor/pharmacists.
Conclusion Difficulty swallowing medicines and medicine dosage form modification were prevalent in the Nepalese population. Medicine dosage form modifications also involved inappropriate modifications due to specialized design of such dosage forms. So, it seems important to provide proper counseling while dispensing such dosage forms.
Meniscal Tear at Knee: Repair or Resect? An Early Experience from a University Hospital in Nepal
Authors: Shrestha R. , Khadka S. K. , Basi A. , Malla M. , Thapa S. , Tripathi A. , Shrestha R. 
Published: December 2022

Background The meniscus plays an important role in maintaining healthy articular cartilage. Meniscus tear, one of the common intra-articular knee lesions, is treated by either debridement or repair.
Objective This study aims at identifying the early outcome of meniscus tears treated by debridement or repair. This study also elaborates on the spectrum of meniscal injuries presented in a tertiary care hospital in Nepal.
Method A retrospective descriptive cross-sectional study was conducted at Orthopedic Department of Dhulikhel Hospital from February 2018 until January 2020 among patients who underwent knee arthroscopies for meniscal tears treated either by debridement or repair. Patients having intra articular fractures, osteochondral injuries and multi-ligament injuries were excluded. The meniscal tears were classified according to location and type of tear. Those patients who had at least one-year of follow up were evaluated with Lysholm score for functional outcome. Data were compiled and analyzed with Microsoft Excel 2011.
Result One hundred and ten cases of meniscal tears were managed over the study period. Ninety-three cases could be traced for outcome evaluation, which included 50 cases of meniscal debridement and 43 cases of meniscal repair. The mean Lysholm score of the patients who received debridement was 81.5 (SD 10.4) and those who received meniscal repair was 84.9 (SD 9.1) (p=0.105). The population distribution was found to be similar in both the groups according to age and sex distribution and associated ligamentous injuries.
Conclusion Good functional outcome was seen for meniscal tears managed with debridement or repair in at least one year follow up and could not establish one modality of management better than the other.
Awareness and Knowledge of Glaucoma and their Associated Factors among People Visiting a Tertiary Level Hospital in Central Nepal
Authors: Shrestha A. , Shrestha P. , Shrestha T. , Shrestha R. M. , Sujakhu D. , Dhakal K. , Thapa G. , Adhikari S. , Karki S. , Adhikari B. 
Published: December 2022

Background Glaucoma is one of the major causes of irreversible blindness globally. Almost 60 million people globally are affected by glaucoma making it the second leading cause of blindness worldwide. Diagnosis of glaucoma early on is vital for timely management and prevention of blindness. However, it is challenging to diagnose it early because it is asymptomatic in the initial stage, and there is also the dearth of appropriate screening tools. Awareness, knowledge, and beliefs are believed to influence the treatment-seeking behavior of people as well as their uptake of services.
Objective To assess the awareness and knowledge about glaucoma among general patients and patient attendants visiting Dhulikhel Hospital.
Method We conducted a cross sectional quantitative study among general patients visiting Dhulikhel Hospital. We collected data using face-to-face interviews with semi-structured questionnaires. We analyzed data in R version 4.0.3 (2020-10-10). We presented numerical variables as mean and standard deviation whereas categorical variables as frequency and percentage. We determined factors associated with awareness and knowledge of glaucoma using logistic regression analysis and estimated adjusted odds ratio (AOR) with 95% confidence interval.
Result Of 379 participants, a total of 214 (56.5%) participants had heard about glaucoma. Out of the participants who heard about glaucoma, the mean knowledge score was 48.3±21.7 and 53.3% had good knowledge on glaucoma. The odds of having heard about glaucoma were two percent lower (AOR=0.98; 95%CI: 0.97-0.99; p-value 0.036) in the older participants compared to one year younger participant, 1.98 (95%CI:1.01-3.86; p-value 0.046) times higher among literates and 2.79 (95%CI: 1.76- 4.41; p-value < 0.001) times among participants with previous ocular examination. The odds of having good knowledge was 1.94 (95%CI: 1.10-3.42; p value 0.021) times among participants with previous ocular examinations.
Conclusion The knowledge and awareness regarding glaucoma in a hospital-visiting population in central Nepal was low. Half of the participants were unaware of the disease glaucoma and half of the participants who heard of the glaucoma had poor knowledge on glaucoma.
Impact of Albendazole Therapy on Clinical and Radiological Outcomes at One Month in Patients with Active Solitary Neurocysticercosis Patients
Authors: Bhattarai S. , Thapa L. , Maharjan A. M. S. , Shrestha A. M. , Shrestha S. , Ghimire M. R. , Upadhyaya S. , Thapa M. 
Published: December 2022

Background Cerebral neurocysticerosis is a common parasitic disease of human nervous system but evidence on duration of albendazole therapy and their outcomes in this condition is inadequate
Objective To evaluate the impact of varying duration of albendazole therapy on the clinical and radiological outcomes at one month in patients with active solitary neurocysticercosis.
Method This is an interventional study conducted at Upendra Devkota Memorial National Institute of Neurological and Allied sciences, Bansbari over 1 year (2017 March - 2018 February). One hundred eighteen patients with new onset seizure secondary to active solitary cysticercal granuloma either received albendazole therapy for 1, 3, 9 or 21 days with the usual care or only received the usual care. Clinical and radiological outcomes were observed at one month follow-up. The difference in the proportion of the outcome measures between intervention and control groups were assessed using chi-square test.
Result Our study included 118 patients with male predominance of 61.9%. Albendazole therapy for 3, 9 and 21 days reduced headache by 57.2%, 70.0% and 63.1% respectively which was higher than those with 1-day therapy or without the therapy. This difference in the proportion was statistically significant at p=0.001. Though seizure recurrence also declined but the difference was not significant (p=0.406) between groups. However, at one-month follow-up, majority of patients who received albendazole for 9 days (14, 70%) and 21 days (14, 73.7%) had normal lesion, while most calcified lesion (21, 67.7%) was observed in those who did not receive albendazole therapy. The difference between lesion among the groups was significant (p < 0.001).
Conclusion Albendazole therapy in patients with active solitary neurocysticercosis for 9 days is as effective as 21 days and better than 3 days in headache control and lesion dissolution but seizure control could be achieved irrespective of the treatment.
PENYULUHAN HUKUM PERAN KOMUNITAS AKADEMIK DALAM PENDIDIKAN DI ERA DIGITAL DI SMA NEGERI 11 JAKARTA TIMUR
Authors: Hasibuan Edi Saputra , Aidy Widya Romasindah 
Published: December 2022

Indonesia amat menjunjung tinggi norma-norma adat dan budaya yang sudah ada sedari dulu, salah satunya dengan gotong royong. Gotong royong atau kerja sama adalah ciri khas Indonesia dan modal masyarakat Indonesia mencapai kemerdekaan dan refleksi jelas nilai-nilai komunal yang menjadi nafas dari kemasyarakatan Indonesia. Nilai komunalitas terlihat dalam berbagai budaya dan kearifan local yang tersebar diseluruh nusantara, seperti budaya rewang, kumpulan PKK dan kebiasaan Siskamling. Akan tetapi, penggunaan media digital dan pandemi COVID-19 menggeser pertemuan masyarakat dari ruang fisik ke ruang maya atau digital. Pola interaksi ini menyebabkan menyebabkan besarnya rasa individualitas dan rentan konflik serta perpecahan. Oleh karena itu diperlukan kesadaran untuk membangun komunitas akademik yang ajeg dan memperhatikan semangat kebersamaan dan gotong royong untuk membangun kembali nilai budaya komunalitas tersebut. Mitra dari kegiatan pengabdian ini adalah SMA Negeri 11 Jakarta Timur yang dihadapkan pada permasalahan minimnya pemahamannya terkait peran komunitas akademik khususnya bagi para siswa SMA dalam dunia digital.
OSMANLI’DAN CUMHURİYET’E ÇALIŞMA HAYATINDA KADIN HAREKETİ
Authors: ÇINAR Tuba 
Published: December 2022

Osmanlı’da kadınlar ekonomik faaliyetlerde ikinci planda kal(dırıl)mışlardı. Bu durum kadınların çalışmadığı anlamına gelmemelidir. Osmanlı Devleti’nin kuruluş yıllarından itibaren farklı mesleklere emek vermiş kadınlar bulunmaktadır. Kadınların çalışma hayatında daha fazla görünmeye başlamaları 19. yüzyılın sonları ve 20. yüzyılın başlarına denk gelir. Batı teknoloji ve sermayesinin Osmanlı’ya girişiyle kadınlar kent merkezlerinde gelişmekte olan ekonomik hayat içinde yer aldılar. Sosyal, ekonomik, fikri dönüşüm, siyasi durum kadın çalışanları artırdı. Çekirdeği 17. yüzyılda kadınların toplumsal hayata katılma çabalarıyla atılan kadın hareketi 20. yüzyıla doğru kökleşti. Kadınlar çalışma hayatında daha aktif oldular. Ancak gerek toplum gerekse devlet çalışma hayatında kadınların hukuklarının korunmasına pek hazırlıklı değildi. Hâlbuki kadınların istihdam edildiği alanlar çeşitlenip, çalışanlar artarken koşulların da iyileştirilmesi beklenirdi. Bunun aksi, devletin kadınları desteklemediğini, emeğini değersizleştirdiğini düşündürebilir.
Bu çalışma devletin emekçi kadın hareketi karşısında nasıl bir tavır benimsediği sorusuna yanıtlar aramaktadır. Kadınların evlerinin dışında çalışmaları hakkında hararetli tartışmalar olup buna tepki gösterenler kadar, devletin içinde bulunduğu çöküşten kurtulması ve modern devletin kurulması için sunulan reçetelerden biri olması bakımından bunu destekleyenler de vardı. Modern hayat, güçlü devlet için kadınların çalışmasına ihtiyaç hissedilmişti. Bu doğrultuda 19. yüzyılda sağlık, sanayi, eğitim alanlarında kadınlara eğitim imkânı sunulmuştu. Kamusal alanda eğitim alan kadınlardan Cumhuriyet döneminde de istifade edilmiştir.
Osmanlı Devleti’nde kadınların çalışma koşulları karşısında adalet ve hak arayışları, grev ve makine kırıcılığı, yeni düzene karşı direnç gibi çeşitli eylemlerdeki yerlerini ele alan bu çalışmanın temel argümanı, Osmanlı kadınlarının kötü çalışma şartları karşısında verdikleri mücadelenin bugünkü kadınların kazanımlarının temelini oluşturduğudur.
Endometrial small extracellular vesicles regulate human trophectodermal cell invasion by reprogramming the phosphoproteome landscape
Authors: Fatmous Monique , Rai Alin , Poh Qi Hui , Salamonsen Lois A. , Greening David W. 
Published: December 2022

A series of cyclical events within the uterus are crucial for pregnancy establishment. These include endometrial regeneration following menses, under the influence of estrogen (proliferative phase), then endometrial differentiation driven by estrogen/progesterone (secretory phase), to provide a microenvironment enabling attachment of embryo (as a hatched blastocyst) to the endometrial epithelium. This is followed by invasion of trophectodermal cells (the outer layer of the blastocyst) into the endometrium tissue to facilitate intrauterine development. Small extracellular vesicles (sEVs) released by endometrial epithelial cells during the secretory phase have been shown to facilitate trophoblast invasion; however, the molecular mechanisms that underline this process remain poorly understood. Here, we show that density gradient purified sEVs (1.06–1.11 g/ml, Alix+ and TSG101+, ∼180 nm) from human endometrial epithelial cells (hormonally primed with estrogen and progesterone vs. estrogen alone) are readily internalized by a human trophectodermal stem cell line and promote their invasion into Matrigel matrix. Mass spectrometry-based proteome analysis revealed that sEVs reprogrammed trophectoderm cell proteome and their cell surface proteome (surfaceome) to support this invasive phenotype through upregulation of pro-invasive regulators associated with focal adhesions (NRP1, PTPRK, ROCK2, TEK), embryo implantation (FBLN1, NIBAN2, BSG), and kinase receptors (EPHB4/B2, ERBB2, STRAP). Kinase substrate prediction highlighted a central role of MAPK3 as an upstream kinase regulating target cell proteome reprogramming. Phosphoproteome analysis pinpointed upregulation of MAPK3 T204/T202 phosphosites in hTSCs following sEV delivery, and that their pharmacological inhibition significantly abrogated invasion. This study provides novel molecular insights into endometrial sEVs orchestrating trophoblast invasion, highlighting the microenvironmental regulation of hTSCs during embryo implantation.
Polydopamine-based nanospheres as nanoplatforms to kill Staphylococcus aureus and to promote wound healing by photothermal therapy
Authors: Hou Zhidian , Yang Min , Huang Ling , Xin Songlin , Yang Huiming , Hou Jiangping 
Published: December 2022

Bacterial infections have always been a threat when it comes to public health accounting for increased morbidity and mortality rates around the world. For the first time, Polydopamine is often used as an ocular surface drug delivery medium to treat some ocular surface diseases based on its good tissue affinity. Mesoporous polydopamine nanospheres (MPDA NPs) under photothermal therapy (PTT) are demonstrated as efficient therapeutic nanoplatforms for Staphylococcus aureus (S. aureus) infection and wound healing. MPDA NPs were found to exhibit excellent photothermal performance, significantly causing an increase in temperature within a short period of NIR-I exposure (808 nm, 1 W cm−2, 6 min). The MPDA NPs under the NIR irradiation remarkably eliminated S. aureus in vitro. Moreover, these synergistic effects turnouts to be phenomenal in vivo, effectively killing and healing S. aureus-infected abscesses in mice. These revealed the combined effect of the intrinsic antibacterial activity of MPDA NPs enhanced upon NIR-I exposure. Hence, MPDA NPs under NIR-I could prove excellent therapeutic nanoplatforms for bacteria-related infections and other biomedical applications.
A tomographic microscopy-compatible Langendorff system for the dynamic structural characterization of the cardiac cycle
Authors: Dejea Hector , Schlepütz Christian M. , Méndez-Carmona Natalia , Arnold Maria , Garcia-Canadilla Patricia , Longnus Sarah L. , Stampanoni Marco , Bijnens Bart , Bonnin Anne 
Published: December 2022

IntroductionCardiac architecture has been extensively investigated ex vivo using a broad spectrum of imaging techniques. Nevertheless, the heart is a dynamic system and the structural mechanisms governing the cardiac cycle can only be unveiled when investigating it as such.MethodsThis work presents the customization of an isolated, perfused heart system compatible with synchrotron-based X-ray phase contrast imaging (X-PCI).ResultsThanks to the capabilities of the developed setup, it was possible to visualize a beating isolated, perfused rat heart for the very first time in 4D at an unprecedented 2.75 μm pixel size (10.6 μm spatial resolution), and 1 ms temporal resolution.DiscussionThe customized setup allows high-spatial resolution studies of heart architecture along the cardiac cycle and has thus the potential to serve as a tool for the characterization of the structural dynamics of the heart, including the effects of drugs and other substances able to modify the cardiac cycle.
A nomogram prediction model for early death in patients with persistent pulmonary hypertension of the newborn
Authors: Lin Chuyang , Mi Jiao , Zhang Yinyue , Duan Sichen , Wu Jinlin , Li Yifei 
Published: December 2022

BackgroundPersistent pulmonary hypertension of the newborn (PPHN) is a major lethal disorder in neonates that leads to an extremely high mortality rate. Thus, the early identification of adverse outcomes in PPHN is critical for clinical practice. This research attempted to develop a nomogram prediction system for assessing the mortality of newborns with PPHN.MethodsTwo hundred and three newborns with PPHN diagnosed from January 2015 to March 2022 were involved in the study. The clinical features of these newborns and pregnancy details were compared between newborns in the survival and lethal groups. Univariable and multivariate analyses were established in sequence to demonstrate the essential risk factors. The nomogram prediction model was built.ResultsA total of 203 newborns were included in the analysis. 136 (67.0%) newborns represented the hospital survival group. Plasma pH value (OR = 0.606, p = 0.000, 95% CI 0.45715–0.80315), septicemia (OR = 3.544, p = 0.000, 95% CI 1.85160–6.78300), and abnormal pregnancy history (OR = 3.331, p = 0.008, 95% CI 1.37550–8.06680) were identified as independent risk factors for neonatal death in newborns associated with PPHN. Finally, the nomogram predictive model was established based on multivariate analysis results, indicating the efficacies of prediction and calibration.ConclusionThis study generated an applicable risk score formula using the plasma pH value, septicemia, and abnormal pregnancy history to recognize neonatal death in newborns with PPHN, presenting a sufficient predictive value and calibration.
Glycohemoglobin: A new warning strategy for non-alcoholic fatty liver disease: Study from the NHANES 2017- 2020
Authors: Hou Jiaxing , Liu Yanyu , Deng Zhen , Sun Jichun , Zhao Mingyi 
Published: December 2022

ContextThe development and progression of Non-alcoholic Fatty Liver Disease (NAFLD) is associated with type 2 diabetes mellitus (T2DM), but there are no studies to demonstrate whether blood glucose levels are associated with the progression of NAFLD.ObjectiveAlterations in glucose metabolism may cause hepatic steatosis and inflammatory responses, leading to hepatocyte damage and promoting NAFLD’s progression. Since glycohemoglobin reflects current blood glucose levels and is easily detectable, the present study aimed to investigate whether glycohemoglobin is associated with liver stiffness in patients with NAFLD.MethodsWe studied 1510 NAFLD patients aged 20-80 in NHANES 2017- March 2020, who were defined using the controlled attenuation parameter (CAP) ≥263 dB/m. Multivariable linear regressions were used to assess the independent association between glycohemoglobin and median liver stiffness measurements (LSM) after adjusting for potential confounders. Subsequently, they were subjected to curve fitting and threshold effect analysis. Stratified analysis was used to find the variables affecting the relationship.ResultsGlycohemoglobin and median LSM showed a positive correlation in different models (β (95% CI): Crude Model: 1.460 (1.053, 1.867); Model 1: 1.476 (1.066, 1.885); Model 2: 1.517 (0.919, 2.115)), and this correlation disappeared when glycohemoglobin ≥8.6%. Furthermore, this correlation was more pronounced in the non-diabetic and former smoking subgroups.ConclusionIn patients with NAFLD, glycohemoglobin may reflect the degree of liver stiffness, and preventing excessive glycohemoglobin may have a positive effect on slowing the progression of NAFLD especially in non-diabetic and former smokers.