bluuebunny/crossref_metadata_2025_split huggingface dataset:
Program Terpadu Raph (Raise Awareness To Prevent Hypertension) Dalam Upaya Pencegahan Hipertensi Pada Remaja Di SMKN 62 Jakarta
Authors: Ekaningrum Annisa Yuri 
Published: September 2023

Hypertension is one of health problem among teenagers and tends to higher risk of morbidity and mortality in adulthood. RAPH program was initiated as hypertension prevention and stands for Raise Awareness to Prevent Hypertension. This program aimed to increase knowledge and attitude related to hypertension prevention. Activities that has implemented were education and giving information related to hypertension prevention and raise awareness through lecture and discussion. This community service activities in the form of Information Communication and Education (IEC), include pre-test activities, material delivery, demonstrations and post-test activities. Participant in this activities was 35 students in SMKN 62 Jakarta. The level of student’s knowledge in the high category during the pre-test was 0 people (0%), while at the post-test increased to 28 people (80%). The activity runs smoothly, students was active asking the questions in the class and knowledge about hypertension prevention and management increased that can be observed by increasing post-test score.
Implementasi Model Project Based Learning Pada Hasil Belajar
Authors: Tria Lestari  , Andi Ali Kisai  , Nurkholis  
Published: September 2023

Permasalahan yang melatarbelakangi penenlitian ini adalah rendahnya hasil belajar peserta didik di SDN 17 Kuningan. Hal tersebut ditunjukkan dengan nilai rata-rata yang dicapai peserta didik berdasarkan nilai ulangan harian mencapai 63,4. Peserta didik yang tuntas belajar (mencapai KKM) terdapat 6 peserta didik (20,69%), sedangkan peserta didik yang tidak tuntas belajar (dibawah KKM) 23 peserta didik (79,31%). Metode penelitian dalam penelitian tindakan kelas dengan pendekatan kualitatif. Penelitian ini menggunakan II siklus yang terdiri dari siklus I dan Siklus II. Setiap siklus terdiri dari kegiatan perencanaan, pelaksanaan, dan refleksi. Subjek penelitian ini yaitu peserta didik kelas VIB SD Negeri 17 Kuningan yang berjumlah 29 peserta didik. Hasi penelitian menunjukan adanya peningkatan hasil belajar siswa sebelum dan setelah dilakukan Penelitian Tindakan Kelas (PTK). Hasil belajar siswa yang mengalami peningkatan pada setiap siklus merupakan bukti keberhasilan penerapan model pembelajaran Project Based Learning (PjBL) pada proses pembelajaran. Berdasarkan hasil belajar peserta didik setiap siklus mengalami peningkatan. Nilai rata-rata hasil ulangan harian peserta didik diperoleh 63,4 dengan jumlah 6 peserta didik (20,69%) tuntas belajar. Nilai rata-rata hasil belajar Siklus I diperoleh 76,2 dengan jumlah 18 peserta didik (62,06%) tuntas belajar, dan nilai rata- rata pada siklus II diperoleh 88,45 dengan jumlah 27 siswa (93,1%) tuntas belajar. Kesimpulannya maka pembelajaran IPA dengan menerapkan model pembelajaran Project Based Learning (PjBL) dapat meningkatkan hasil belajar peserta didik. Saran utamanya kepada guru agar lebih meningkatkan wawasan tentang model pembelajaran yang inovatif sehingga dalam pembelajaran menjadi tidak monoton.
Pengaruh Kemampuan Berpikir Kritis Siswa dalam Pembelajaran Matematika
Authors: Reskinda Ramadhani  , Lintang Kusumawardani  , Hazna Dyah Ekaputri  , Intan Suryaningrum  , Wieline Dewi Azzahra  , Khoirunnisa Nabila 
Published: September 2023

Tujuan dari penelitian ini adalah untuk mengetahui kemampuan berpikir kritis siswa dan menyelesaikan masalah matematika di kelas rendah sekolah dasar. Jenis penelitian ini adalah penelitian deksriptif kuantitatif. Penentuan sampel dan representative dalam penelitian ini adalah menggunakan Teknik sampling non-probability sampling dengan Teknik sampling jenuh karena jumlah populasi kecil kurang dari 20 orang. Sampel penelitian ini adalah siswa kelas II SDN 02 Karangwage yang berjumlah 19 siswa. Dalam penelitian ini menggunakan angket dengan jumlah 6 pertanyaan untuk menguji kekritisan siswa dalam berpikir dan menyelesaikan masalah matematika di kelas rendah sekolah dasar. Data yang digunakan dalam menganalisis yaitu uji t one sample test dengan bantuan aplikasi SPSS. Hasil penelitian ini diperoleh bahwa sebagian besar siswa sudah memiliki kemampuan berpikir kritis untuk menyelesaikan masalah matematika yang terbukti oleh skor nilai yang lebih dari KKM (>75). Namun, masih ada 1 siswa yang skor nilainya tidak terlalu tinggi dari KKM yaitu 75,5 dari keseluruhan nilai yang didapat teman-temannya. Berdasarkan data tersebut disimpulkan bahwa nilai dari t hitung = 6.649 dan juga sig.(2-tailed) yang diperoleh adalah sebesar 0.000 yang berarti nilai sig.(2-tailed) < 0.05 maka H0 ditolak. Sehingga kemampuan berpikir kritis siswa berpengaruh terhadap hasil belajar matematika.
In vitro enzymatic degradation of the PTMC/cross-linked PEGDA blends
Authors: Li Wei , Lin Meina , Wang Chenchao , Lu Yongping , Sui Yu , Ni Xiang , Guo Jing , Jiang Miao , Yang Liqun , Cui Hong 
Published: September 2023

Introduction: Poly(1,3-trimethylene carbonate) (PTMC) is a flexible amorphous polymer with good degradability and biocompatibility. The degradation of PTMC is critical for its application as a degradable polymer, more convenient and easy-to-control cross-linking strategies for preparing PTMC are required.Methods: The blends of poly(trimethylene carbonate) (PTMC) and cross-linked poly(ethylene glycol) diacrylate (PEGDA) were prepared by mixing photoactive PEGDA and PTMC and subsequently photopolymerizing the mixture with uv light. The physical properties and in vitro enzymatic degradation of the resultant PTMC/cross-linked PEGDA blends were investigated.Results: The results showed that the gel fraction of PTMC/cross-linked PEGDA blends increased while the swelling degree decreased with the content of PEGDA dosage. The results of in vitro enzymatic degradation confirmed that the degradation of PTMC/cross-linked PEGDA blends in the lipase solution occurred under the surface erosion mechanism, and the introduction of the uv cross-linked PEGDA significantly improved the resistance to lipase erosion of PTMC; the higher the cross-linking degree, the lower the mass loss.Discussion: The results indicated that the blends/cross-linking via PEGDA is a simple and effective strategy to tailor the degradation rate of PTMC.
Medial and lateral knee contact forces during walking, stair ascent and stair descent are more affected by contact locations than tibiofemoral alignment in knee osteoarthritis patients with varus malalignment
Authors: Valente Giordano , Grenno Giulia , Dal Fabbro Giacomo , Zaffagnini Stefano , Taddei Fulvia 
Published: September 2023

Introduction: Knee OA progression is related to medial knee contact forces, which can be altered by anatomical parameters of tibiofemoral alignment and contact point locations. There is limited and controversial literature on medial-lateral force distribution and the effect of anatomical parameters, especially in motor activities different from walking. We analyzed the effect of tibiofemoral alignment and contact point locations on knee contact forces, and the medial-lateral force distribution in knee OA subjects with varus malalignment during walking, stair ascending and stair descending.Methods: Fifty-one knee OA subjects with varus malalignment underwent weight-bearing radiographs and motion capture during walking, stair ascending and stair descending. We created a set of four musculoskeletal models per subject with increasing level of personalization, and calculated medial and lateral knee contact forces. To analyze the effect of the anatomical parameters, statistically-significant differences in knee contact forces among models were evaluated. Then, to analyze the force distribution, the medial-to-total contact force ratios were calculated from the fully-informed models. In addition, a multiple regression analysis was performed to evaluate correlations between forces and anatomical parameters.Results: The anatomical parameters significantly affected the knee contact forces. However, the contact points decreased medial forces and increased lateral forces and led to more marked variations compared to tibiofemoral alignment, which produced an opposite effect. The forces were less medially-distributed during stair negotiation, with medial-to-total ratios below 50% at force peaks. The anatomical parameters explained 30%–67% of the variability in the knee forces, where the medial contact points were the best predictors of medial contact forces.Discussion: Including personalized locations of contact points is crucial when analyzing knee contact forces in subjects with varus malalignment, and especially the medial contact points have a major effect on the forces rather than tibiofemoral alignment. Remarkably, the medial-lateral force distribution depends on the motor activity, where stair ascending and descending show increased lateral forces that lead to less medially-distributed loads compared to walking.
Huntingtin CAG-expansion mutation results in a dominant negative effect
Authors: Laundos Tiago L. , Li Shu , Cheang Eric , De Santis Riccardo , Piccolo Francesco M. , Brivanlou Ali H. 
Published: September 2023

Introduction: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether HTT loss of function or gain of toxicity results from mutation, remains a matter of debate.Methods: In this study, we genetically modulated wild-type or mutant HTT expression levels in isogenic human embryonic stem cells to systematically investigate their contribution to HD-specific phenotypes.Results: Using highly reproducible and quantifiable in vitro micropattern-based assays, we observed comparable phenotypes with HD mutation and HTT depletion. However, halving endogenous wild-type HTT levels did not strongly recapitulate the HD phenotypes, arguing against a classical loss of function mechanism. Remarkably, expression of CAG-expanded HTT in non-HD cells induced HD like phenotypes akin to HTT depletion.Discussion: By corollary, these results indicate a dominant negative effect of mutated HTT on its wild-type counterpart. Complementation with additional copies of wild-type HTT ameliorated the HD-associated phenotypes, strongly supporting a classical dominant negative mechanism. Understanding the molecular basis of this dominant negative effect will guide the development of efficient clinical strategies to counteract the deleterious impact of mutant HTT on the wild-type HTT function.
Valve-in-valve procedures for degenerated surgical and transcatheter aortic valve bioprostheses using a latest-generation self-expanding intra-annular transcatheter heart valve
Authors: Schaefer Andreas , Demal Till Joscha , Bhadra Oliver D. , Grundmann David , Voigtländer Lisa , Waldschmidt Lara , Schirmer Johannes , Pecha Simon , Schneeberger Yvonne , Schofer Niklas , Sörensen Nils , Blankenberg Stefan , Reichenspurner Hermann , Seiffert Moritz , Conradi Lenard 
Published: September 2023

BackgroundValve-in-valve (ViV) transfemoral transcatheter aortic valve implantation (TAVI) for failing aortic surgical bioprostheses or transcatheter heart valves (THV) has demonstrated a reasonable clinical and hemodynamic efficacy. Traditionally, self-expanding (SE) supra-annular THV are considered to result in superior hemodynamics compared with balloon-expandable intra-annular THV after ViV. However, so far no data are found on latest-generation intra-annular SE THV for aortic ViV procedures which might be superior with regard to coronary access or subsequent valve reintervention.AimWe herein aim to evaluate a latest-generation SE intra-annular THV for aortic ViV procedures.Materials and methodsBetween May 2022 and November 2022, five consecutive patients (4/5 female with mean age of 76.2 years and mean Society of Thoracic Surgeons predicted risk of mortality score of 2.9%) received ViV TAVI using the Navitor system (Abbott, Chicago, IL, USA) for treatment of failing surgical bioprostheses or THV. Data were retrospectively analyzed according to updated Valve Academic Research Consortium 3 (VARC-3) definitions.ResultsAt 30 days, absence of mortality and VARC-3 adjudicated clinical endpoints were documented. Echocardiography at 30 days revealed complete absence of paravalvular leakage and single-digit mean transvalvular gradients (mean of 6.0 mmHg) in all patients.ConclusionThe investigated intra-annular SE THV results in excellent 30-day outcomes for aortic ViV procedures for failing surgical bioprostheses or THV. Despite the intra-annular design, hemodynamic results were excellent, even in small bioprostheses. Ease of use of this valve platform is reflected by only two cycles of resheathing in five ViV procedures with hemodynamic stability during all steps of valve deployment.
Comparison of analog and digital patient decision aids for the treatment of depression: a scoping review
Authors: Sedlakova Jana , Westermair Anna Lisa , Biller-Andorno Nikola , Meier Christoph A. , Trachsel Manuel 
Published: September 2023

IntroductionPatient decision aids (PDAs) are important tools to empower patients and integrate their preferences and values in the decision-making process. Even though patients with mental health problems have a strong interest in being more involved in decision making about their treatment, research has mainly focused on PDAs for somatic conditions. In this scoping review, we focus on patients suffering from depression and the role of PDAs for this patient group. The review offers an overview of digital and analog PDAs, their advantages and disadvantages as well as recommendations for further research and development.MethodsA systematic search of the existing literature guided by the Cochrane Handbook for Systematic Reviews and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - extension for scoping reviews (PRISMA-ScR) was conducted. Three electronic literature databases with the appropriate thematic focus were searched (PubMed, PsycInfo, and Web of Science). The search strategy used controlled and natural language to search for the key concepts decision aids and depression. The articles were selected in a two-step process guided by predefined inclusion and exclusion criteria. We narratively synthetized information extracted from 40 research articles.ResultsWe included 40 articles in our review. Our review revealed that there is more focus on digital PDAs in research than in clinical practice. Digitalization can enhance the benefits of PDAs by developing tools that are more efficient, interactive, and personalized. The main disadvantages of both types of PDAs for the treatment of depression are related to time, dissemination, and capacity building for the health care providers. Digital PDAs need to be regularly updated, effective strategies for their dissemination and acceptance need to be identified, and clinicians need sufficient training on how to use digital PDAs. There is more research needed to study which forms of PDAs are most appropriate for various patient groups (e.g., older adults, or patients with comorbidities), and to identify the most effective ways of PDAs' integration in the clinical workflow. The findings from our review could be well aligned with the International Patient Decision Aids Standards.DiscussionMore research is needed regarding effective strategies for the implementation of digital PDAs into the clinical workflow, ethical issues raised by the digital format, and opportunities of tailoring PDAs for diverse patient groups.
“Online, the counselor can't see me cry”: a systematic literature review on emotion and computer-mediated care
Authors: De Coninck Sarah , Emmers Elke 
Published: September 2023

IntroductionComputer-mediated care is becoming increasingly popular, but little research has been done on it and its effects on emotion-related outcomes. This systematic literature review aims to create an overview that addresses the research question: “Is there a relationship between computer-mediated care and emotional expression, perception, and emotional and (long-term) emotion outcomes?”MethodThis systematic literature review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and used five eligibility criteria, namely, (1) participants: adults seeking support; (2) intervention: eHealth; (3) diagnostic criteria: transdiagnostic concept of difficulty identifying, expressing, and/or regulating emotions (e.g., alexithymia); (4) comparator: either face-to-face care or no comparator; and (5) study design: quantitative studies or qualitative studies. Quality was assessed using the QualSyst tool.ResultsThe analysis includes 25 research papers. Self-paced interventions appear to have a positive effect on emotion regulation. Videoconferencing interventions improved emotion regulation from before to after treatment but worsened emotion regulation compared with face-to-face treatment.DiscussionThe lack of variation in the modalities studied and the emotion measurements used make it difficult to draw responsible conclusions. Future research should examine how different modalities affect the real-time communication of emotions and how non-verbal cues influence this.
The influence of basal detachment strength on formation of the southwestern Sichuan fold-thrust belt: insights from discrete-element numerical simulations
Authors: Wang Yanqi , Wang Lining , Ren Rong , Wei Guoqi , Chen Zhuxin , Su Nan , Zhang Yuqing 
Published: September 2023

Introduction: The southwestern Sichuan fold-thrust belt (SWSB) is a duplex detachment system and features the basal Precambrian detachment at a depth of approximately 15–17 km and the upper Mid-Triassic detachment. Moreover, the SWSB undergoes forward-breaking propagation during the Cenozoic. To date, the mechanism and kinematic evolution governing the SWSB in this thrusting deformation as well as the way the two detachments control the structural deformation pattern of the SWSB remains unknown.Methods: In this work, three discrete-element numerical models with the same strong upper detachment but basal detachments with different mechanical strengths and thicknesses were designed to study the deformation of the SWSB.Results: The results indicate that for the Model I with a strong frictional basal detachment with thickness of 500 m, most deformation and thrust faults concentrate near the mobile backwall. Model I exhibits characteristics such as linearly increasing wedge height and stepwise increasing wedge width and slope angle. For the Model II with a modest frictional basal detachment with thickness of 500 m, the strain and deformation propagate into the foreland quickly and multiple back-thrust and thrust faults form on the upper detachment in the second thrusting period. The first thrusting period in Model II, exhibits similarities with Model I. However, in the second period, the wedge reaches a stable state, and its geometry remains constant. In this stage, the deformation propagates along the shallow detachment into the right side of the model. The geometry and activity of thrust faults in the foreland differ significantly in the model III with a modest frictional basal detachment but a greater thickness. Two additional pop-up structures are generated in the second period in this model. The first half of the first thrusting period is similar to the first two models. In the second half of the first period and the second period, the wedge is in a stable state. In the first stage of the shortening, all models undergo a transition from a subcritical state to entering a supercritical state, which indicates that the deformation is progressing rapidly along the basal detachment towards the right side of the model.Discussion: The results of Model III are consistent with the deformation pattern of the SWSB. The study of the kinematics and interaction between two detachments could help hydrocarbon exploration beneath the upper detachment.
Effect of tamoxifen in patients with thin endometrium who underwent frozen–thawed embryo transfer cycles: a retrospective study
Authors: Ji Mengxia , Fu Xiaohua , Huang Danni , Wu Ruifang , Jiang Yunqing , Huang Qiongxiao 
Published: September 2023

IntroductionThin endometrium leads to an impaired implantation rate. The aim of the study is to compare the clinical outcomes of tamoxifen (TAM) and hormone replacement therapy (HRT) used in patients with thin endometrium (&lt;7mm) in frozen-thawed embryo transfer (FET)cycles.MethodsA total of 176 FET cycles with thin endometrium were retrospectively analyzed in our center from Jan 2020 to May 2022. According to patients' own will, 112 patients were allocated to the HRT group and 64 patients chose the TAM protocol. Clinical outcomes were compared between two groups.ResultThe duration of treatment was shorter in the TAM group(12.03±2.34d) than the HRT group (16.07±2.52 d), which was statistically different (p&lt;0.05). The endometrial thickness on the transfer day of the TAM group (7.32±1.28 mm) was significantly thicker than that of the HRT group (6.85±0.89mm, p&lt;0.05). The clinical pregnancy rate of the TAM group (50.0%) was higher than that of the HRT group (36.6%), but there was no significant difference (p &gt;0.05). The early miscarriage rate was significantly lower in the TAM group compared with the HRT group (5.9% Vs 26.8%, adjusted OR 0.10, p&lt;0.05), while the live birth rate was higher in the TAM group (46.9% Vs 26.8%, adjusted OR 2.24, p&lt;0.05) compared with the HRT group.ConclusionFor patients with thin endometrium, TAM effectively improved the endometrial thickness and increased the live birth rate. TAM can be used as an alternative protocol for patients with thin endometrium.
Identification of endoplasmic reticulum stress-related biomarkers of diabetes nephropathy based on bioinformatics and machine learning
Authors: Su Jiaming , Peng Jing , Wang Lin , Xie Huidi , Zhou Ying , Chen Haimin , Shi Yang , Guo Yan , Zheng Yicheng , Guo Yuxin , Dong Zhaoxi , Zhang Xianhui , Liu Hongfang 
Published: September 2023

BackgroundsDiabetes nephropathy (DN) is a growing public health concern worldwide. Renal dysfunction impairment in DN is intimately linked to ER stress and its related signaling pathways. Nonetheless, the underlying mechanism and biomarkers for this function of ER stress in the DN remain unknown.MethodsMicroarray datasets were retrieved from the Gene Expression Omnibus (GEO) database, and ER stress-related genes (ERSRGs) were downloaded from the MSigDB and GeneCards database. We identified hub ERSRGs for DN progression by intersecting ERSRGs with differentially expressed genes and significant genes in WGCNA, followed by a functional analysis. After analyzing hub ERSRGs with three machine learning techniques and taking the intersection, we did external validation as well as developed a DN diagnostic model based on the characteristic genes. Immune infiltration was performed using CIBERSORT. Moreover, patients with DN were then categorized using a consensus clustering approach. Eventually, the candidate ERSRGs-specific small-molecule compounds were defined by CMap.ResultsSeveral biological pathways driving pathological injury of DN and disordered levels of immune infiltration were revealed in the DN microarray datasets and strongly related to deregulated ERSRGs by bioinformatics multi-chip integration. Moreover, CDKN1B, EGR1, FKBP5, GDF15, and MARCKS were identified as ER stress signature genes associated with DN by machine learning algorithms, demonstrating their potential as DN biomarkers.ConclusionsOur research sheds fresh light on the function of ER stress in DN pathophysiology and the development of early diagnostic and ER stress-related treatment targets in patients with DN.