bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice
Authors: Pan Wei , Zhao Jinxiu , Wu Jiacheng , Xu Daxiang , Meng Xianran , Jiang Pengfei , Shi Hongli , Ge Xing , Yang Xiaoying , Hu Minmin , Zhang Peng , Tang Renxian , Nagaratnam Nathan , Zheng Kuiyang , Huang Xu-Feng , Yu Yinghua 
Published: February 2023

Abstract
Background
Gut homeostasis, including intestinal immunity and microbiome, is essential for cognitive function via the gut-brain axis. This axis is altered in high-fat diet (HFD)-induced cognitive impairment and is closely associated with neurodegenerative diseases. Dimethyl itaconate (DI) is an itaconate derivative and has recently attracted extensive interest due to its anti-inflammatory effect. This study investigated whether intraperitoneal administration of DI improves the gut-brain axis and prevents cognitive deficits in HF diet-fed mice.

Results
DI effectively attenuated HFD-induced cognitive decline in behavioral tests of object location, novel object recognition, and nesting building, concurrent with the improvement of hippocampal RNA transcription profiles of genes associated with cognition and synaptic plasticity. In agreement, DI reduced the damage of synaptic ultrastructure and deficit of proteins (BDNF, SYN, and PSD95), the microglial activation, and neuroinflammation in the HFD-fed mice. In the colon, DI significantly lowered macrophage infiltration and the expression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in mice on the HF diet, while upregulating the expression of immune homeostasis-related cytokines (IL-22, IL-23) and antimicrobial peptide Reg3γ. Moreover, DI alleviated HFD-induced gut barrier impairments, including elevation of colonic mucus thickness and expression of tight junction proteins (zonula occludens-1, occludin). Notably, HFD-induced microbiome alteration was improved by DI supplementation, characterized by the increase of propionate- and butyrate-producing bacteria. Correspondingly, DI increased the levels of propionate and butyrate in the serum of HFD mice. Intriguingly, fecal microbiome transplantation from DI-treated HF mice facilitated cognitive variables compared with HF mice, including higher cognitive indexes in behavior tests and optimization of hippocampal synaptic ultrastructure. These results highlight the gut microbiota is necessary for the effects of DI in improving cognitive impairment.

Conclusions
The present study provides the first evidence that DI improves cognition and brain function with significant beneficial effects via the gut-brain axis, suggesting that DI may serve as a novel drug for treating obesity-associated neurodegenerative diseases.
The impact of correctional officer gender on prison suicide
Authors: Carter TaLisa J. , Whittle Tanya N. 
Published: February 2023

AbstractCorrectional officers are critical members of the prison community. However, scholarship rarely considers how correctional officers contribute to prison outcomes instead largely focusing on importation (individual) and deprivation (organizational) factors related to the incarcerated population. This is also true regarding how scholars and practitioners approach suicide committed by incarcerated people, one of the leading causes of death in US carceral institutions. Using quantitative data from confinement facilities across the United States, this study answers the research question: What is the relationship between prison suicide rates and correctional officer gender? Results show that deprivation factors (variables related to the carceral environment) influence prison suicide. Additionally, gender diversity among correctional officers reduces the rate of prison suicide. Implications for future research and practice and limitations of the study are also discussed.
CAR-T cell therapy followed by allogenic hematopoietic stem cell transplantation yielded comparable outcome between Ph like ALL and other high-risk ALL
Authors: Dai Hai-ping , Kong Dan-qing , Shen Hong-jie , Cui Wei , Wang Qian , Li Zheng , Yin Jia , Kang Li-qing , Yu Lei , Wu De-pei , Tang Xiao-wen 
Published: February 2023

AbstractIt was previously believed that patients with Ph-like ALL had poorer prognosis compared with other B-ALL subgroups due to resistance to conventional chemotherapy and lack of targeted drugs. CAR-T therapy has been successfully applied in the treatment of relapsed and refractory B-ALL. Currently, there are few data on whether CAR-T therapy can alter the outcome of Ph-like ALL. Here we included 17 Ph-like, 23 Ph+ and 51 other B-ALL patients, who received autologous CAR T-cell therapy and subsequently allogenic stem cell transplantation. Patients in the Ph-like group and B-ALL-others group were younger that those in the Ph+ group (P=0.001). Ph-like and Ph+ ALL patients showed higher white blood cell counts at diagnosis (P=0.025). The percentage of patients with active disease before receiving CAR T-cells infusion was 64.7%, 39.1% and 62.7% in the Ph-like, Ph+ and B-ALL-others groups. The response rates to CAR-T therapy were 94.1% (16/17), 95.6% (22/23) and 98.0% (50/51) in the Ph-like, Ph+ and B-ALL-others groups. Measurable residual disease negative CR was achieved in 64.7% (11/17), 60.9% (14/23) and 54.9% (28/51) in the Ph-like, Ph+ and B-ALL-others groups, respectively. The estimated rates of 3-year overall survival (65.9%±16.5%, 59.7%±10.5% and 61.6%±7.3%, P=0.758) and 3-year relapse-free survival (59.8%±14.8%, 63.1%±10.5% and 56.3%±7.1%, P=0.764) were comparable among the Ph-like, Ph+ and B-ALL-others groups. Estimated 3-year cumulative relapse rate was 7.8%±0.6%, 23.4%±0.9% and 29.0%±0.4% (P=0.241). Our findings suggest that CART followed by allo-HSCT results in a comparable prognosis in Ph-like ALL and other high-risk B-ALL.Trial registration ClinicalTrials. gov, NCT03275493, Registered on September 7, 2017, prospectively registered and NCT03614858, Registered on August 3, 2018, prospectively registered.
A comparative study on the audio-visual evaluation of the grand Song of the Dong soundscape
Authors: Mao Linqing , Zhang Xin , Ma Jianjun , Jia Yihong 
Published: February 2023

Abstract
Soundscape heritage records the cultural connotations of different ethnic groups, the destruction, and the disappearance of certain heritage makes its preservation urgent. This work aims to explore the influence of audio-visual different sensory stimuli on the subjective cognition, perceptual dimension and value evaluation of the Grand Song of the Dong soundscape heritage. We have conducted an audio-visual interaction experiment, using 2D video and high-fidelity audio systems to show typical visual elements and cultural scenes of the Grand Song of the Dong, and combined them with questionnaires to collect subjective data. The results show that the visual stimuli have no effect on the subjective evaluation of the Grand Song of the Dong soundscape, and that the different social characteristics of the participants are the main reason for the variations. The influence of audio-visual interaction on the perception of the of the Grand Song of the Dong soundscape is greater, with an enhanced perceptual dimension than the single auditory sensory, i.e., the scale dimension, indicating that visual stimuli can enhance the sensing of spatial limitation. The introduction of the visual element results in higher scores for each heritage value than the auditory element alone, indicating a positive impact on the value evaluation. The results of these studies provide a theoretical basis for the living transmission and holistic conservation of the Grand Song of the Dong and their scenes.
Prediction of hepatic lymph node metastases based on magnetic resonance imaging before and after preoperative chemotherapy in patients with colorectal liver metastases underwent surgical resection
Authors: Zhu Hai-bin , Xu Da , Sun Xue-Feng , Li Xiao-Ting , Zhang Xiao-Yan , Wang Kun , Xing Bao-Cai , Sun Ying-Shi 
Published: February 2023

Abstract
Background
Patients with colorectal liver metastases (CRLM) combined with hepatic lymph node (HLN) metastases have a poor prognosis. In this study, we developed and validated a model using clinical and magnetic resonance imaging (MRI) parameters to predict HLN status before surgery.

Methods
A total of 104 CRLM patients undergoing hepatic lymphonodectomy with pathologically confirmed HLN status after preoperative chemotherapy were enrolled in this study. The patients were further divided into a training group (n = 52) and a validation group (n = 52). The apparent diffusion coefficient (ADC) values, including ADCmean and ADCmin of the largest HLN before and after treatment, were measured. rADC was calculated referring to the target liver metastases, spleen, and psoas major muscle (rADC-LM, rADC-SP, rADC-m). In addition, ADC change rate (Δ% ADC) was quantitatively calculated. A multivariate logistic regression model for predicting HLN status in CRLM patients was constructed using the training group and further tested in the validation group.

Results
In the training cohort, post-ADCmean (P = 0.018) and the short diameter of the largest lymph node after treatment (P = 0.001) were independent predictors for metastatic HLN in CRLM patients. The model’s AUC was 0.859 (95% CI, 0.757-0.961) and 0.767 (95% CI 0.634-0.900) in the training and validation cohorts, respectively. Patients with metastatic HLN showed significantly worse overall survival (p = 0.035) and recurrence-free survival (p = 0.015) than patients with negative HLN.

Conclusions
The developed model using MRI parameters could accurately predict HLN metastases in CRLM patients and could be used to preoperatively assess the HLN status and facilitate surgical treatment decisions in patients with CRLM.
The 2022 focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension
Authors: Kim Hack-Lyoung , Lee Eun Mi , Ahn Shin Young , Kim Kwang-il , Kim Hyeon Chang , Kim Ju Han , Lee Hae-Young , Lee Jang Hoon , Park Jong-Moo , Cho Eun Joo , Park Sungha , Shin Jinho , Kim Young-Kwon 
Published: February 2023

AbstractHypertension is the leading cause of death in human being, which shows high prevalence and associated complications that increase the mortality and morbidity. Controlling blood pressure (BP) is very important because it is well known that lowering high BP effectively improves patients’ prognosis. This review aims to provide a focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension. The importance of ambulatory BP and home BP monitoring was further emphasized not only for the diagnosis but also for treatment target. By adopting corresponding BPs, the updated guideline recommended out-of-office BP targets for both standard and intensive treatment. Based on the consensus on corresponding BPs and Systolic Blood Pressure Intervention Trial (SPRINT) revisit, the updated guidelines recommended target BP in high-risk patients below 130/80 mmHg and it applies to hypertensive patients with three or more additional cardiovascular risk factors, one or more risk factors with diabetes, or hypertensive patients with subclinical organ damages, coronary or vascular diseases, heart failure, chronic kidney disease with proteinuria, and cerebral lacunar infarction. Cerebral infarction and chronic kidney disease are also high-risk factors for cardiovascular disease. However, due to lack of evidence, the target BP was generally determined at < 140/90 mmHg in patients with those conditions as well as in the elderly. Updated contents regarding the management of hypertension in special situations are also discussed.
Sex-specific differences in neuromuscular activation of the knee stabilizing muscles in adults - a systematic review
Authors: Steiner Martina , Baur Heiner , Blasimann Angela 
Published: February 2023

Abstract
Introduction
The rupture of the anterior cruciate ligament (ACL) is one of the most common injuries of the knee. Women have a higher injury rate for ACL ruptures than men. Various indicators for this sex-specific difference are controversially discussed.

Aim
A systematic review of the literature that compares surface electromyography (EMG) values of adult female and male subjects to find out if there is a difference in neuromuscular activation of the knee stabilizing muscles.

Methods
This systematic review has been guided and informed by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies which examined sex-specific differences with surface EMG measurements (integral, root mean squares, mean values, analysis of time and amplitude) of the knee stabilizing muscles were retrieved via searches from the databases PubMed, CINAHL, Embase, CENTRAL and SPORTDiscus. The risk of bias of included studies was assessed with the National Heart, Lung and Blood Institute (NHLBI) study quality assessment tool. A synthesis of results was performed for relevant outcomes.

Results
Fifteen studies with 462 healthy participants, 233 women (mean age 21.9 (± 2.29) years) and 299 men (mean age 22.6 (± 2.43) years), were included in the systematic review. The methodological quality of the studies was mostly rated “fair” (40%). A significantly higher activity of the muscles vastus lateralis and vastus medialis was found in females, in three studies. Two studies found significantly lower neuromuscular activity in the muscles biceps femoris and semitendinosus in females. All other included studies found no significant differences or reported even contradicting results.

Conclusion
The controversial findings do not allow for a concluding answer to the question of a sex-specific neuromuscular activation. Further research with higher statistical power and a more homogeneous methodical procedure (tasks and data normalisation) of the included studies may provide insight into possibly existing sex-specific differences in neuromuscular activation. This systematic review could help to improve the methodical design of future studies to get a more valid conclusion of the issue.

Trial registration
CRD42020189504.
Carbon neutral Bhutan: sustaining carbon neutral status under growth pressures
Authors: Yangka Dorji , Rauland Vanessa , Newman Peter 
Published: February 2023

Abstract
Background
Bhutan has pledged to remain carbon neutral (CN) in perpetuity. Whether they can sustain this is questionable due to the country’s increasing economic growth (GDP) and commitment to gross national happiness (GNH) outcomes, both of which can lead to a rise in greenhouse gas (GHG) emissions. The nexus between GHG, GNH and GDP is the essence of the Paris Agreement and Sustainable Development Goals global project.

Results
Through scenario modelling using the Long-range Energy Alternative Planning (LEAP) model, the study finds that the carbon neutral declaration will derail between 2037 and 2050 without mitigation measures. By putting in place mitigation measures especially in the industry and transport sectors, CN can be retained even under high growth pressure, which may cost just 2% of GDP. CN can be easily retained under low economic growth, but this could undermine GNH. High growth will require immediate interventions to enable electrification of industry and transport.

Conclusions
The options to remain CN will require Bhutan to adopt more efficient technologies and electrify industry and transport under both low and high growth scenarios. The additional cost to the Bhutanese economy is feasible through low and high growth opportunities. The options are similar to those confronting emerging nations struggling with issues of climate commitments under economic growth pressures. All will need to adapt their specific economic contexts to achieve the simultaneous objectives of the Sustainable Development Goals whilst addressing the net zero Paris agenda. Bhutan shows it is possible.
The impact of UAS aerial ignition on prescribed fire: a case study in multiple ecoregions of Texas and Louisiana
Authors: Lawrence Brett L. , Mundorff Kevin , Keith Eric 
Published: February 2023

Abstract
Background
Small Unmanned Aerial System (UAS) technologies and their applications have expanded in recent years, to include aerial ignition support in prescribed fire and wildland fire settings. In 2019, we incorporated the use of UAS aerial ignition into our existing prescribed fire program of over 20 years. To assess its impact, comparisons of UAS and non-UAS burns were performed on burn data from 2012 to 2021, with 58 total UAS burns conducted from 2019 to 2021. A subset of these burns conducted at Cook’s Branch Conservancy in Montgomery County, TX, included post-burn assessment data, which we used to compare UAS and non-UAS fire effects.

Results
Non-parametric significance tests were used to analyze and compare non-UAS burning before (2012–2018) and after (2019–2021) the incorporation of the UAS, and UAS burning from 2019 to 2021. Response variables included ha day−1 burned and six different post-burn assessment metrics. Principal findings were that from 2019 to 2021, UAS burns were 61 ha day−1 or 129% more efficient than non-UAS burning and required one extra staff member to pilot the UAS on average. This increase enabled a previously unachievable efficiency in terms of hectares burned each year vs days burned each year when using the UAS. While fire effects were less severe for most post-burn assessment metrics during UAS burning, burn results still met fuel management goals when compared to non-UAS burning.

Conclusions
A large increase in ha day−1 was previously unachievable, making the UAS a viable tool for accomplishing safer and more effective prescribed burn operations in the limited number of suitable days available. When managed responsibly, UAS aerial ignition is poised to have a positive impact on the safe and effective application of prescribed fire, resulting in more achievable conservation and fuel management goals.
Knowledge and awareness of physical therapy role in evaluating and treating temporomandibular disorders among physical therapists in Saudi Arabia
Authors: Almutairi Sattam M. , Alqoussi Taif F. , Alassaf Fai S. , Alharbi Amirah S. , Alrumihe Sara M. , Alharbi Majd S. , Almutairi Marzouq K. 
Published: February 2023

Abstract
Background
Practitioners, including physical therapists, are not proficiently trained to evaluate and treat individuals with temporomandibular disorders. The purpose of this study is to evaluate the knowledge and awareness of examining and treating temporomandibular disorders among physical therapists in Saudi Arabia.

Methods
An online questionnaire was distributed to physical therapists on different social media platforms. The survey covered demographics characteristics and knowledge of examining and treating temporomandibular disorders. Descriptive statistics were used for data analysis.

Results
A total of 143 participants with a mean of age of 30 (± 6.6) years participated in this study. The majority of participants (n = 109; 76.2%) did not take educational courses on temporomandibular disorders; more than half (n = 84; 58.7%) had never evaluated or treated individuals with temporomandibular disorders. Most physical therapists were aware that they could treat individuals with temporomandibular disorders (n = 121, 84.6%). The most common evaluation methods were temporomandibular joint palpation, jaw movement during opening and closing, and palpation of the masticatory muscles (n = 56, 95%); (n = 49, 83%); (n = 48, 81%), respectively. The common methods used for treatment were therapeutic exercise strengthening, manual therapy, and patient education (n = 49; 83%; n = 46; 78%; n = 33; 56%), respectively. Thirty-one participants (53%) referred patients to other practitioners.

Conclusion
This preliminary study indicates there is a fair level of knowledge, low confidence, low education, and low clinical experience for physical therapists in the evaluation and treatment of temporomandibular disorders in Saudi Arabia. More attention is needed on physical therapy education programs and post-graduate education courses on temporomandibular disorders.
Longitudinal trajectories in negative symptoms and changes in brain cortical thickness: 10-year follow-up study
Authors: Canal-Rivero Manuel , Ruiz-Veguilla Miguel , Ortiz-García de la Foz Victor , López-Díaz Alvaro , Garrido-Torres Nathalia , Ayesa-Arriola Rosa , Vazquez-Bourgon Javier , Mayoral-van Son Jacqueline , Brambilla Paolo , Kircher Tilo , Romero-García Rafael , Crespo-Facorro Benedicto 
Published: February 2023

BackgroundUnderstanding the evolution of negative symptoms in first-episode psychosis (FEP) requires long-term longitudinal study designs that capture the progression of this condition and the associated brain changes.AimsTo explore the factors underlying negative symptoms and their association with long-term abnormal brain trajectories.MethodWe followed up 357 people with FEP over a 10-year period. Factor analyses were conducted to explore negative symptom dimensionality. Latent growth mixture modelling (LGMM) was used to identify the latent classes. Analysis of variance (ANOVA) was conducted to investigate developmental trajectories of cortical thickness. Finally, the resulting ANOVA maps were correlated with a wide set of regional molecular profiles derived from public databases.ResultsThree trajectories (stable, decreasing and increasing) were found in each of the three factors (expressivity, experiential and attention) identified by the factor analyses. Patients with an increasing trajectory in the expressivity factor showed cortical thinning in caudal middle frontal, pars triangularis, rostral middle frontal and superior frontal regions from the third to the tenth year after the onset of the psychotic disorder. The F-statistic map of cortical thickness expressivity differences was associated with a receptor density map derived from positron emission tomography data.ConclusionsStable and decreasing were the most common trajectories. Additionally, cortical thickness abnormalities found at relatively late stages of FEP onset could be exploited as a biomarker of poor symptom outcome in the expressivity dimension. Finally, the brain areas with less density of receptors spatially overlap areas that discriminate the trajectories of the expressivity dimension.