bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic dysfunction in obesity is related to impaired suppression of fatty acid release from adipose tissue by insulin
Authors: Schleh Michael W. , Ryan Benjamin J. , Ahn Cheehoon , Ludzki Alison C. , Varshney Pallavi , Gillen Jenna B. , Van Pelt Douglas W. , Pitchford Lisa M. , Howton Suzette M. , Rode Thomas , Chenevert Thomas L. , Hummel Scott L. , Burant Charles F. , Horowitz Jeffrey F. 
Published: March 2023

AbstractObjectiveThe aims of this study were: 1) to assess relationships among insulin‐mediated glucose uptake with standard clinical outcomes and deep‐phenotyping measures (including fatty acid [FA] rate of appearance [FA Ra] into the systemic circulation); and 2) to examine the contribution of adipocyte size, fibrosis, and proteomic profile to FA Ra regulation.MethodsA total of 66 adults with obesity (BMI = 34 [SD 3] kg/m2) were assessed for insulin sensitivity (hyperinsulinemic‐euglycemic clamp), and stable isotope dilution methods quantified glucose, FA, and glycerol kinetics in vivo. Abdominal subcutaneous adipose tissue (aSAT) and skeletal muscle biopsies were collected, and magnetic resonance imaging quantified liver and visceral fat content.ResultsInsulin‐mediated FA Ra suppression associated with insulin‐mediated glucose uptake (r = 0.51; p < 0.01) and negatively correlated with liver (r = −0.36; p < 0.01) and visceral fat (r = −0.42; p < 0.01). aSAT proteomics from subcohorts of participants with low FA Ra suppression (n = 8) versus high FA Ra suppression (n = 8) demonstrated greater extracellular matrix collagen protein in low versus high FA Ra suppression. Skeletal muscle lipidomics (n = 18) revealed inverse correlations of FA Ra suppression with acyl‐chain length of acylcarnitine (r = −0.42; p = 0.02) and triacylglycerol (r = −0.51; p < 0.01), in addition to insulin‐mediated glucose uptake (acylcarnitine: r = −0.49; p < 0.01, triacylglycerol: r = −0.40; p < 0.01).ConclusionsInsulin's ability to suppress FA release from aSAT in obesity is related to enhanced insulin‐mediated glucose uptake and metabolic health in peripheral tissues.
Investigation of the effect of chelating nitrogenous bases on click reactions on poly[(methyl acrylate)‐co‐(5‐azido‐1‐pentene)]
Authors: Hession Benjamin J , Botcha Niharika Krishna , Mukherjee Anusree , Scholz Carmen 
Published: March 2023

AbstractClick reactions on poly[(methyl acrylate)‐co‐(5‐azido‐1‐pentene)], synthesized by radical polymerization of methyl acrylate and 1‐bromo‐5‐pentene, and converted into the click‐ready azido form by nucleophilic substitution with sodium azide, were studied. Propargyl benzoate and propargyl acetate were clicked onto the polymeric substrate, with the latter known to be a poor click reactant. The impact of solvents (dimethyl formamide (DMF) and tetrahydrofuran (THF)), catalytic systems (CuSO4/Na ascorbate, [Cu(BPMEN)(ClO4)2]/Na ascorbate, bromotris(triphenylphosphine) copper(I) ([CuBr(PPh3)3])) and the addition of chelating nitrogenous bases (triethylamine (TEA), diisopropylethylamine, N,N,N′,N″,N″‐pentamethyldiethylenetriamine) on the degree of conversion was analyzed. Only reactions catalyzed with [CuBr(PPh3)3] led to high or complete conversions in both solvents. Reactions catalyzed with the pre‐catalyst complexes CuSO4⋅5H2O and [(CuBPMEN)(ClO4)2], which require the in situ reduction of Cu(II) to Cu(I) by sodium ascorbate, yielded incomplete conversions in both solvents. Adding chelating nitrogenous bases, with TEA being the most effective, yielded complete conversions for propargyl benzoate with all three catalytic systems in DMF. Adding TEA to reactions of propargyl acetate in DMF increased conversion by 17.9% for CuSO4⋅5H2O/Na ascorbate and 29.6% for [(CuBPMEN)(ClO4)2]/Na ascorbate. The addition of chelating bases was more effective in DMF than in THF, which was also the less suited solvent in reactions without chelating bases. The results show that click reactions with propargyl reagents that cannot increase the nucleophilicity of the vinylidene‐like β‐carbon through electron conjugation yield lower conversions. The effectiveness of catalytic systems that undergo in situ reductions can be enhanced by nitrogenous chelating bases that stabilize the Cu(I) stage. © 2023 Society of Industrial Chemistry.
Dynamic monomers for Hot Lithography: The UPy motif as a versatile tool towards stress relaxation, reprocessability, and 3D printing
Authors: Ruppitsch Larissa Alena , Ecker Jakob , Koch Thomas , Ehrmann Katharina , Stampfl Jürgen , Liska Robert 
Published: March 2023

AbstractSupramolecular polymers can substantially influence the dynamic mechanical properties in slightly crosslinked polymer networks. One prominent example of supramolecular building blocks is 2‐ureido‐4[1H]‐pyrimidinones (UPy). Combining UPy‐terminated supramolecular segments with classical covalent‐reactive monomers implements dynamic behavior in photopolymerizable systems. In this work, a UPy‐based methacrylic monomer (up to 20 mol%) was introduced in a classical photopolymerizable methacrylate matrix. The influence of the UPy‐motif on the reactivity and (thermo)mechanical properties was investigated via RT‐NIR photorheology, DMTA, and tensile testing. The dynamic behavior was characterized via stress relaxation and reprocessing studies to demonstrate the dynamic effects of photopolymers containing the UPy building block compared to difunctional photopolymers with similar structural features. In a final step, the UPy‐based photopolymerizable system was applied in bulk in a Hot Lithography printing process at elevated temperatures yielding complex 3D‐printed parts with high resolution and precision.
Intolerance of uncertainty, cognitive fusion, coping self‐efficacy and self‐perceived burden in patients diagnosed with cancer
Authors: Eyni Sanaz , Mousavi Seyede Elham 
Published: March 2023

AbstractBackgroundAs the proportion of older people worldwide increases, cancer cases and deaths from cancer are rising. Suffering from cancer has a profound impact on the daily lives of patients and their families. Cancer patients often perceive themselves as a burden, which affects their quality of life; therefore, this study investigated the relationship between intolerance of uncertainty, cognitive fusion, and self‐perception as burdens and the mediating role of coping self‐efficacy in patients diagnosed with cancer.MethodsIn this descriptive, correlational, and structural equation modeling study, 400 patient diagnosed with cancer who were hospitalized in the oncology ward of Imam Khomeini Hospital in Ardabil in the first half of 2022 were selected as the sample and answered Casino et al. self‐perceived burden questionnaire, Gillanders et al. cognitive fusion questionnaire, Carleton et al. uncertainty intolerance scale, and Merleau et al. cancer behavior scale.ResultsBased on the results, the fitting indices of the research conceptual model were confirmed. Intolerance of uncertainty, cognitive fusion, and coping self‐efficacy had a direct and significant relationship with self‐perceived burden in patients diagnosed with cancer (p < 0.01); also, intolerance of uncertainty and cognitive fusion through coping self‐efficacy had an indirect effect on self‐perceived burden in patients diagnosed with cancer (p < 0.05).ConclusionTherefore, intolerance of uncertainty, cognitive fusion, and coping self‐efficacy plays a substantial role in the incidence of self‐perceived burden in patients diagnosed with cancer and targeting these three components by psychological therapies can reduce the perception of self‐perception as burden which is effective in patients diagnosed with cancer.
Effect of Al/O ratio on underwater explosion energy characteristics of CL‐20‐based aluminized explosives
Authors: Yao Lina , Zhao Shengxiang , Jia Xianzhen , Wang Haiqing , Wang Cailing 
Published: March 2023

AbstractTo study the underwater explosion energy characteristics of CL‐20‐based aluminized explosives with different Al/O ratio, underwater detonation parameters of explosives, including the shock wave peak pressure, the decay time, the bubble pulsation period, the shock wave energy and the bubble energy at 1 m, were measured by a series of underwater explosion experiments. The calculation model of CL‐20‐based aluminized explosive in the pool was established by using Ansys LS‐DYNA software and was calculated the shock wave energy and bubble pulsation period. The results showed that Al/O ratio significantly changed the energy output structure of CL‐20‐based aluminized explosives. With increasing Al/O ratio, the proportion of shock wave energy in the total energy decreased, while the proportion of bubble energy increased. When Al/O ratio was 0.35, the shock wave peak pressure and shock wave energy of the explosive were the largest, and when the ratio was 0.6, the bubble period and total energy reach their maximum; when the ratio was 0.94, the bubble energy and the bubble pulsation reached the maximum. The experimental values are in good agreement with the simulation results, and the model can be used to estimate the underwater detonation parameters of CL‐20‐based aluminized explosives with different Al/O ratio.
Single‐cell analysis of localized prostate cancer patients links high Gleason score with an immunosuppressive profile
Authors: Adorno Febles Victor R. , Hao Yuan , Ahsan Aarif , Wu Jiansheng , Qian Yingzhi , Zhong Hua , Loeb Stacy , Makarov Danil V. , Lepor Herbert , Wysock James , Taneja Samir S. , Huang William C. , Becker Daniel J. , Balar Arjun V. , Melamed Jonathan , Deng Fang‐Ming , Ren Qinghu , Kufe Donald , Wong Kwok‐Kin , Adeegbe Dennis O. , Deng Jiehui , Wise David R. 
Published: March 2023

AbstractBackgroundEvading immune surveillance is a hallmark for the development of multiple cancer types. Whether immune evasion contributes to the pathogenesis of high‐grade prostate cancer (HGPCa) remains an area of active inquiry.MethodsThrough single‐cell RNA sequencing and multicolor flow cytometry of freshly isolated prostatectomy specimens and matched peripheral blood, we aimed to characterize the tumor immune microenvironment (TME) of localized prostate cancer (PCa), including HGPCa and low‐grade prostate cancer (LGPCa).ResultsHGPCa are highly infiltrated by exhausted CD8+ T cells, myeloid cells, and regulatory T cells (TRegs). These HGPCa‐infiltrating CD8+ T cells expressed high levels of exhaustion markers including TIM3, TOX, TCF7, PD‐1, CTLA4, TIGIT, and CXCL13. By contrast, a high ratio of activated CD8+ effector T cells relative to TRegs and myeloid cells infiltrate the TME of LGPCa. HGPCa CD8+ tumor‐infiltrating lymphocytes (TILs) expressed more androgen receptor and prostate‐specific membran antigen yet less prostate‐specific antigen than the LGPCa CD8+ TILs. The PCa TME was infiltrated by macrophages but these did not clearly cluster by M1 and M2 markers.ConclusionsOur study reveals a suppressive TME with high levels of CD8+ T cell exhaustion in localized PCa, a finding enriched in HGPCa relative to LGPCa. These studies suggest a possible link between the clinical‐pathologic risk of PCa and the associated TME. Our results have implications for our understanding of the immunologic mechanisms of PCa pathogenesis and the implementation of immunotherapy for localized PCa.
Unpaired deep adversarial learning for multi‐class segmentation of instruments in robot‐assisted surgical videos
Authors: Nema Shubhangi , Vachhani Leena 
Published: March 2023

AbstractPurposeImage segmentation of instruments in the raw surgical videos is a critical component of intraoperative assistance softwares. Challenges include addressing rendered overlays occluding the instrument while providing pivotal input to instrument tracking frameworks and, train the segmentation process with limited labelled data available from surgical videos.MethodThe proposed adversarial network, InstruSegNet uses unpaired training (eliminating need for massive paired data) for automated multi‐class surgical instrument segmentation in raw surgical videos with complex backgrounds. The proposed method is applied for single/multiple robotic and rigid instruments and optimised on least square Generative Adversarial Networks loss.ResultPromising validation has been conducted on the publicly available dataset. Proposed approach for multi‐class segmentation of robotic and rigid instruments meets outstanding performance in terms of accuracy and surpasses the existing methods.ApplicationThis work facilitates segmenting instrument information without manual interventions from raw videos providing means to code surgeon's actions for developing intelligent assistance software.
Fault‐alarm based hybrid control design for uncertain periodic piecewise time‐varying systems with actuator constraints
Authors: Sakthivel Rathinasamy , Satheesh Thangavel , Harshavarthini Shanmugam , Chadli Mohammed , Saat Shakir 
Published: March 2023

AbstractThis paper is concerned with the stabilization problem for continuous‐time periodic piecewise time‐varying uncertain systems with time‐varying delay, actuator failures and external disturbances. Specifically, the actuator failure consists of both unknown actuator partial failure and actuator bias failure. Based on multiple threshold values, in this work, a fault‐alarm based hybrid control protocol is developed, which is used to switch between robust and reliable controllers accurately and timely by eliminating false alarms. To be precise, a set of sufficient stability criteria is established in the form of linear matrix inequalities (LMIs) by considering an appropriate Lyapunov‐Krasovskii functional with time‐varying periodic piecewise positive‐definite matrices. Furthermore, the desired time‐varying robust and reliable controller gain matrices can be reckoned based on developed LMI‐based constraints. Eventually, two numerical examples are presented, which include the mass‐spring damper systems, to show the superiority and practicability of the designed controller.
The ℓ∞/p$$ {\ell}_{\infty /p} $$‐gains for discrete‐time observer‐based event‐triggered systems
Authors: Park Hae Yeon , Choi Hyung Tae , Kim Jung Hoon 
Published: March 2023

AbstractThis paper aims at computing two types of system gains for discrete‐time observer‐based event‐triggered systems (ETSs) via the linear matrix inequality (LMI) approach. More precisely, an event‐trigger mechanism (ETM) is considered for the discrete‐time control systems consisting of a static controller and a Luenberger observer to determine whether or not the input signal for the controller is updated to the estimated value from the observer. For a tractable treatment of the input/output behavior of such ETMs, we derive their closed‐form representation through a piecewise linear difference equation. Based on this representation, we establish LMI‐based computation approaches to the gains for the ETSs from to (denoted by ) with . Finally, the effectiveness of the overall arguments is verified through a numerical example.
What kind of leaders can promote the disclosure of information on the sustainable development goals?
Authors: Garrido‐Ruso María , Aibar‐Guzmán Beatriz , Suárez‐Fernández Óscar 
Published: March 2023

AbstractAs the person responsible for a company's strategies and disclosure policies, the CEO is the architect of its CSR strategy. This paper analyzes which CEO's attributes influence the level of disclosure of information about business contribution to the SDGs. Based on the Upper Echelons Theory, a set of hypotheses on the influence of several CEO attributes (demographic and professional characteristics as well as personal traits) on SDGs disclosure have been tested in a sample of the leading Spanish companies for the period 2015–2021 using ordinal regressions for panel data. The results show that education level, nationality, and narcissism are the CEO attributes that significantly affect the level of SDG disclosure. Specifically, companies whose CEOs have a higher level of education, are Spanish (local), and are narcissist tend to disclose more information about the SDGs. This study aims to contribute to literature by providing new empirical evidence on an emerging research topic and by providing a glimpse into the CEO “profile” that may favor a company's propensity to disclose information on the SDGs.
Life is a gift: Value cosmologies in Hollywood cinema
Authors: Ecks Stefan 
Published: March 2023

AbstractIs life “priceless,” or can life be bought and sold like a commodity? Anthropological theory has not yet been able to integrate incommensurable value with commensurable value. But such an integrated theory of value exists—not explicitly in theory but implicitly in everyday ethics and fictional narratives. I analyze how the movie Titanic, one of the most commercially valuable artefacts of all time, reveals a comprehensive ideology of how life and material wealth should be valued. Titanic works through key themes in economic anthropology: social inequality, class struggle, gift/commodity distinctions, the meaning of money, and inalienable possessions. Titanic demonstrates that the tension between ethical values and economic value can be resolved when short‐term individual gains are transcended by a mutuality of being that reaches beyond death. Titanic proposes that American capitalism can integrate core cultural values with economic freedom and self‐realization.
External enablers and entrepreneurial ecosystems: The brokering role of the anchor tenant in capacitating grassroots ecopreneurs
Authors: Juma Norma , Olabisi Joy , Griffin‐EL Eliada 
Published: March 2023

AbstractResearch SummaryWe study how environmental enablers, specifically disruptive ecological shifts, and subsequent regulatory activity, led to the formation of a local ecopreneur ecosystem in Kenya and how this process was facilitated by the brokerage role of an international NGO. Drawing from the entrepreneurial ecosystem literature, and using a strategic network perspective to conceptually map salient interorganizational ties, multilevel engagement, and resource generation, we utilize qualitative grounded theory analysis to argue that environmental changes have catalyzed the regulatory change towards the formation of an entrepreneurial ecosystem for low‐resourced ecopreneurs. This process is facilitated through ecosystem brokering through an anchor tenant that accelerates knowledge, resources, and viable exchanges to advance venture sustainability.Managerial SummaryOur study unpacks how regulatory responses to environmental shifts enable the systemic development of venture creation. We explore how environmental changes, first in the natural environment, and subsequently, the regulatory environment—influence ecosystem emergence for entrepreneurial activity. We present three dimensions of regulatory enablement that shift conditions to favor venture building. Problem framing by the regulatory sector signals potential opportunities for entrepreneurs for value creation. Prioritization of this problem, emphasized in the government's regulation, sets new agendas and implies that new rules and resources would be allocated towards such opportunities. New rules also reconfigure boundaries to invite new actors and interactions into the discourse on environmental preservation in Kenya.
Special Issue: Nanotherapeutics in Women's Health Emerging Nanotechnologies for Triple‐Negative Breast Cancer Treatment
Authors: Torres Quintas Sofia , Canha‐Borges Ana , Oliveira Maria José , Sarmento Bruno , Castro Flávia 
Published: March 2023

AbstractBreast cancer appears as the major cause of cancer‐related deaths in women, with more than 2 260 000 cases reported worldwide in 2020, resulting in 684 996 deaths. Triple‐negative breast cancer (TNBC), characterized by the absence of estrogen, progesterone, and human epidermal growth factor type 2 receptors, represents ≈20% of all breast cancers. TNBC has a highly aggressive clinical course and is more prevalent in younger women. The standard therapy for advanced TNBC is chemotherapy, but responses are often short‐lived, with high rate of relapse. The lack of therapeutic targets and the limited therapeutic options confer to individuals suffering from TNBC the poorest prognosis among breast cancer patients, remaining a major clinical challenge. In recent years, advances in cancer nanomedicine provided innovative therapeutic options, as nanoformulations play an important role in overcoming the shortcomings left by conventional therapies: payload degradation and its low solubility, stability, and circulating half‐life, and difficulties regarding biodistribution due to physiological and biological barriers. In this integrative review, the recent advances in the nanomedicine field for TNBC treatment, including the novel nanoparticle‐, exosome‐, and hybrid‐based therapeutic formulations are summarized and their drawbacks and challenges are discussed for future clinical applications.
Revealing Structural Insights of Solid Electrolyte Interphase in High‐Concentrated Non‐Flammable Electrolyte for Li Metal Batteries by Cryo‐TEM
Authors: Zhang Qing , Zhou Chuan , Li Menghao , Zhu Yuanmin , Wei Xianbin , Shen Shaocheng , Ji Zongwei , Luo Guangfu , Cheng Yifeng , Yang Xuming , Wang Zhijie , Zou Lingfeng , Zeng Lin , Lin Junhao , Li Lei , Francisco Joseph S. , Gu Meng 
Published: March 2023

AbstractHigh‐concentrated non‐flammable electrolytes (HCNFE) in lithium metal batteries prevent thermal runaway accidents, but the microstructure of their solid electrolyte interphase (SEI) remains largely unexplored, due to the lack of direct imaging tools. Herein, cryo‐HRTEM is applied to directly visualize the native state of SEI at the atomic scale. In HCNFE, SEI has a uniform laminated crystalline‐amorphous structure that can prevent further reaction between the electrolyte and lithium. The inorganic SEI component, Li2S2O7, is precisely identified by cryo‐HRTEM. Density functional theory (DFT) calculations demonstrate that the final Li2S2O7 phase has suitable natural transmission channels for Li‐ion diffusion and excellent ionic conductivity of 1.2 × 10‐5 S cm‐1.
Tuning Carbon Defect in Copper Single‐Atom Catalysts for Efficient Oxygen Reduction
Authors: Yao Xiuyun , Zhu Youqi , Xia Tianyu , Han Zhanli , Du Changliang , Yang Lifen , Tian Jiachen , Ma Xilan , Hou Jianhua , Cao Chuanbao 
Published: March 2023

AbstractDefect chemistry in carbon matrix shows great potential for promoting the oxygen reduction reaction (ORR) of metal single‐atom catalysts. Herein, a modified pyrolysis strategy is proposed to tune carbon defects in copper single‐atom catalysts (Cu‐SACs) to fully understand their positive effect on the ORR activity. The optimized Cu‐SACs with controllable carbon defect degree and enhanced active specific surface area can exhibit improved ORR activity with a half‐wave potential of 0.897 VRHE, ultrahigh limiting current density of 6.5 mA cm−2, and superior turnover frequency of 2.23 e site−1 s−1. The assembled Zn–air batteries based on Cu‐SACs can also show well‐retained reversibility and voltage platform over 1100 h charge/discharge period. Density functional theory calculations reveal that suitable carbon defects can redistribute charge density of Cu‐N4 active sites to weaken the O–O bond in adsorbed OOH* intermediate and thus reduce its dissociation energy. This discovery offers a universal strategy for fabricating superior single‐atom catalysts with high‐efficiency active sites toward energy‐directed applications.