bluuebunny/crossref_metadata_2025_split huggingface dataset:
Position-based assessment of head impact frequency, severity, type, and location in high school American football
Authors: Bagherian Amirhossein , Abbasi Ghiri Alireza , Ramzanpour Mohammadreza , Wallace James , Elashy Sammy , Seidi Morteza , Memar Marzieh 
Published: January 2025

IntroductionResearch on head impact characteristics, especially position-specific investigations in football, has predominantly focused on collegiate and professional levels, leaving a gap in understanding the risks faced by high school players. Therefore, this study aimed to investigate the effect of three factors—player position, impact location, and impact type—on the frequency, severity, and characteristics of impacts in high school American football. Additionally, we examined whether and how player position influences the distribution of impact locations and types.MethodsSixteen high school football players aged 14 to 17 participated in this study. Validated mouthguard sensors measured head impact kinematics, including linear acceleration, angular acceleration, and angular velocity across ten games, and were used to identify impact locations on the head. Video recordings verified true impacts, player position, and impact type at the moment of each recorded impact. Head impact kinematics were input into a head finite element model to determine the 95th percentile of the maximum principal strain and strain rate. Several novel and systematic approaches, such as normalization, binning, and clustering, were introduced and utilized to investigate the frequency and severity of head impacts across the three aforementioned factors while addressing some of the limitations of previous methodologies in the field. To that end, the number of recorded impacts for each player position during each game was divided by the number of players in that position, and then averaged across ten games. Instead of averaging, impacts were categorized into four severity bins: low, mid-low, mid-high and high. Clusters for the three factors were also identified according to the characteristics of impacts.Results and DiscussionResults revealed that offensive linemen and running backs experienced a higher normalized frequency and more severe impacts across all head kinematics and brain tissue deformation parameters. Frontal impacts, resulting from “head-to-head” impacts, were the most frequent and severe impact locations. The distributions of impact location and type for each specific position were distinct. Offensive linemen had the highest proportion of frontal impacts, while quarterbacks and centerbacks had more impacts at the rear location. These findings can inform interventions in game regulations, training practices, and helmet design to mitigate injury risks in high school football.
Acute effects of tissue flossing on boxers with chronic knee pain
Authors: Chen Jie , Wang Qirong , Zhao Zhiguang , Song Qipeng , Zhao Peng , Wang Dan 
Published: January 2025

ObjectivesTo explore the acute intervention effects of tissue flossing on chronic knee pain (CKP) in boxers.MethodsEighteen boxers with CKP (12 male/6 female) were randomly divided into an experimental group (EG) with tissue flossing (n = 9) and a control group (CG) (n = 9). The visual analog scale (VAS), Lysholm knee function score, flexion range of motion (ROM), maximal isometric extensor muscle strength, and stability of the knee were measured pre- and post-intervention (EG: 3-minute tissue flossing, CG: rest).ResultsVAS (F = 15.849, p = 0.001, η2p = 0.498) and Lysholm knee function (F = 9.327, p = 0.008, η2p = 0.357) significantly improved more in the EG than in the CG. There was a significant difference for maximal isometric extensor muscle strength (F = 17.769, p = 0.001, η2p = 0.542) and knee stability (F = 13.844, p = 0.002, η2p = 0.464) but no significant difference for ROM (F = 1.218, p = 0.287, η2p = 0.075) between the EG and CG.ConclusionTissue flossing can reduce knee pain, improve knee function, increase knee extensor strength, and improve knee stability in boxers with CKP.
Comparative efficacy of different drugs in acute heart failure with renal dysfunction: a systematic review and network meta-analysis
Authors: Lv Qianyu , Wu Qian , Yang Yingtian , Li Lanlan , Ye Xuejiao , Wang Shihan , Lv Yanfei , Wang Manshi , Li Yushan 
Published: January 2025

ObjectiveThis network meta-analysis was to compare the efficacy of different drugs on cardiac function, renal function, and clinical outcomes in patients with acute heart failure (AHF) accompanied by renal dysfunction.MethodsPubMed, EMBASE, Cochrane Library, and Web of Science were searched to screen all clinical trials of AHF between January 1st 2001 and March 31th 2024. The primary outcome measures were N-terminal pro-B type natriuretic peptide (NT-proBNP), B-type natriuretic peptide (BNP), glomerular filtration rate (GFR), blood urea nitrogen, serum creatinine, all-cause mortality within 60 days, and cardiovascular mortality.ResultsAfter screening 30,697 citations, 13 studies (21,745 patients) were included, and drugs including nesiritide, dopamine, tolvaptan, levosimendan, dobutamine, furosemide, and spirolactone, and high dose of diuretics (HDD, furosemide, and spirolactone) were estimated. The results indicated that HDD had the best efficacy in reducing NT-proBNP levels. In detail, HDD notably reduced NT-proBNP levels compared to conventional treatment or placebo (PLC) [MD = −950.24; 95% CrI (−1,832.21, −64.12)]. Levosimendan significantly increased GFR levels compared to PLC [MD = 14.46; 95% CrI (3.88, 25.97)] and tolvaptan [MD = 13.83; 95% CrI (2.31, 25.33)]. No significant difference was found in 60-day all-cause mortality and cardiovascular mortality across drugs.ConclusionHDD showed the best efficacy in reducing NT-proBNP levels compared with dopamine and nesiritide, and levosimendan could significantly improve GFR levels, with no marked difference in the effect of various drugs on 60-day all-cause mortality. Hence, HDD and levosimendan may be optimal agents in the treatment of AHF with renal dysfunction.Systematic Review RegistrationPROSPERO, identifier (CRD42023454616).
Predictive value of CT-based and AI-reconstructed 3D-TAPSE in patients undergoing transcatheter tricuspid valve repair
Authors: Kirchner Johannes , Gerçek Muhammed , Omran Hazem , Friedrichs Kai Peter , Rudolph Felix , Rossnagel Tobias , Piran Misagh , Goncharov Arseniy , Ivannikova Maria , Rudolph Volker , Rudolph Tanja Katharina 
Published: January 2025

BackgroundThe tricuspid annular plane systolic excursion (TAPSE) assessed by echocardiography has failed in predicting outcomes in patients with severe tricuspid regurgitation (TR) undergoing transcatheter tricuspid valve intervention (TTVI). Considering the complex shape of the tricuspid annulus and right ventricle, as well as the difficult echocardiographic image acquisition of the right heart, cardiac computed tomography (CT) might be superior for the analysis of the annular excursion. Thus, this study aimed to analyze whether CT-captured TAPSE provides additional value in predicting outcomes after TTVI.Methods and resultsFor TTVI procedure planning, 75 patients (mean age, 77 ± 8 years; 61% female) with severe TR underwent full cardiac cycle CT. Septal, lateral, anterior, and posterior TAPSE, as well as TAPSE- volume, were analyzed. Indexed anterior and posterior (iTAPSE) and TAPSE volume were reduced in patients with right ventricular ejection fraction &lt;45%. At 1 year after TTVI (mean follow-up, 193 ± 146days), the combined endpoint of death and rehospitalization occurred in significantly fewer patients with posterior iTAPSE &gt;4.5 mm/m2 (17.2% vs. 63.6%; HR 0.225, CI 0.087–0.581; P &lt; 0.001) and in patients with iTAPSE volume &gt;9 ml/m2 (16.4% vs. 57.1%; HR: 0.269 CI 0.105–0.686; P = 0.003). Echocardiographic TAPSE correlated best with lateral CT-based TAPSE, although both failed in predicting outcomes after TTVI. In multivariate Cox regression, posterior iTAPSE was found to be a significant predictor of outcome 1 year after TTVI.ConclusionsPosterior iTAPSE is an independent predictor of cardiovascular outcomes among patients undergoing TTVI. Furthermore, CT-measured TAPSE has incremental value and refines risk stratification for clinical outcomes in patients undergoing TTVI.
The correlation between serum MHR and NLR and the severity of coronary lesions in NSTE-ACS patients of different genders
Authors: Yang Yanping , Lv Xiaobing , Tan Kai , Li Kai , Li Shaohua , Meng Xia , Chen Yunyun , Wang Fuqing , Xin Hui 
Published: January 2025

BackgroundTo study the relationship between the monocyte/high-density lipoprotein cholesterol ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) and coronary artery stenosis in Non-st-elevation acute coronary syndromes (NSTE-ACS) patients of different genders.MethodsA total of 253 control and 800 NSTE-ACS patients were included, and clinic data (29 items) were also collected. NSTE-ACS patients were divided into low-risk (0–23) and high-risk (≥ 23) groups based on the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score. Then, Spearman correlation and multivariate logistic regression analyses were performed to study the associated factors of high-risk SYNTAX score in male and female NSTE-ACS patients, respectively. Finally, the receiver operating characteristic (ROC) curve was used to calculate the diagnostic value of MHR and NLR for predicting high-risk SYNTAX scores in male NSTE-ACS patients.ResultsSixteen distinct factors differed between the high- and low-risk groups in male NSTE-ACS patients, a significantly higher number than female NSTE-ACS patients. Gout/hyperuricemia, smoking, NLR, and MHR are independent risk factors for arterial stenosis. At the same time, high-density lipoprotein and left ventricular ejection fraction (LVEF) are found to be protective factors in male NSTE-ACS patients. Fibrinogen, apolipoprotein B/A, and neutrophils are identified as independent risk factors for arterial stenosis in female NSTE-ACS patients, while LVEF and high-density lipoprotein are protective factors. Finally, combined NLR and MHR [p = 0.000, 95% confidence interval (CI) = 0.726–0.810] had better predictive efficacy on the degree of arterial vessel stenosis than NLR or MHR alone. The sensitivity and specificity of the ROC curve were 0.672 and 0.769, respectively.ConclusionThe combination of MHR and NLR shows potential for predicting and assessing the severity of coronary artery stenosis in male patients with NSTE-ACS.
Eosinophilic granulomatosis with polyangiitis; a distinctive presentation with myocarditis and autoimmune haemolytic anaemia: case report
Authors: Ayish Doaa Abdulwahab Mohammed , Ayish Fatma , Khamjan Asayel , Mohamed Amal. H. , Abdalghani Nagla , Albasheer Osama 
Published: January 2025

BackgroundEosinophilic granulomatosis with polyangiitis (EGPA) is an extremely rare type of vasculitis characterized by inflammation within small blood vessels or tissues that may cause damage to the lungs, heart, kidneys, and other organs. Here, we present a rare case of EGPA with cardiac involvement that presented with acute heart failure.Clinical findingsA 44-year-old woman with a history of bronchial asthma and sinusitis presented with fever, shortness of breath, fatigue, unintentional weight loss, and polyarthritis. Physical examination revealed bilateral basal crepitation and mononeuritis multiplex.DiagnosisThe peripheral blood smear revealed red blood cells of different sizes and shapes (dimorphic features), more eosinophils, low hemoglobin, and higher lactate dehydrogenase (LDH) levels. Cardiac magnetic resonance imaging (CMR) revealed global hypokinesia and features suggestive of myocarditis. Echocardiography showed a low ejection fraction of 25%. Thus, the patient diagnosed with EPGA and myocarditis presented with acute heart failure.InterventionsThe patient was administered high-dose corticosteroids (intravenous bolus methylprednisolone 500 mg for three days, followed by 1 mg/kg of prednisolone) and cyclophosphamide 750 mg intravenously.OutcomeAfter one months, the patient showed a marked improvement in clinical and laboratory parameters. The ejection fraction improved to 30%–40%, the eosinophil count returned to normal, and the haemolytic anaemia resolved. The patient was sent home and shifted to mycophenolate mofetil 1 g twice a day as maintenance therapy.ConclusionPatients with EGPA have a higher morbidity and mortality rate when they have cardiac involvement. The pathophysiological mechanism of cardiac involvement in EGPA warrants consideration of immunosuppressive therapy in addition to standard heart failure treatment.
Terminal complement complex deposition on chondrocytes promotes premature senescence in age- and trauma-related osteoarthritis
Authors: Ruths Leonie , Hengge Jana , Teixeira Graciosa Q. , Haffner-Luntzer Melanie , Ignatius Anita , Riegger Jana 
Published: January 2025

BackgroundThe complement system is locally activated after joint injuries and leads to the deposition of the terminal complement complex (TCC). Sublytic TCC deposition is associated with phenotypical alterations of human articular chondrocytes (hAC) and enhanced release of inflammatory cytokines. Chronic inflammation is a known driver of chondrosenescence in osteoarthritis (OA). Therefore, we investigated whether TCC deposition contributes to stress-induced premature senescence (SIPS) during aging in vivo and after ex vivo cartilage injury.MethodsFemoral condyles of male 13-week-old and 72-week-old CD59-ko (higher TCC deposition), C6-deficient (insufficient TCC formation), and C57BL/6 (WT) mice were collected to assess age-related OA. Furthermore, macroscopically intact human and porcine cartilage explants were traumatized and cultured with/without 30% human serum (HS) to activate the complement system. Explants were additionally treated with clusterin (CLU, TCC inhibitor), N-acetylcysteine (NAC, antioxidant), Sarilumab (IL-6 receptor inhibitor), STAT3-IN-1 (STAT3 inhibitor), or IL-1 receptor antagonist (IL-1RA) in order to investigate the consequences of TCC deposition. Gene and protein expression of senescence-associated markers such as CDKN1A and CDKN2A was determined.ResultsIn the murine aging model, CD59-ko mice developed after 72 weeks more severe OA compared to C6-deficient and WT mice. mRNA analysis revealed that the expression of Cdkn1a, Cdkn2a, Tp53, Il1b, and Il6 was significantly increased in the cartilage of CD59-ko mice. In human cartilage, trauma and subsequent stimulation with HS increased mRNA levels of CDKN1A, CDKN2A, and IL6, while inhibition of TCC formation by CLU reduced the expression. Antioxidative therapy with NAC had no anti-senescent effect. In porcine tissue, HS exposure and trauma had additive effects on the number of CDKN2A-positive cells, while Sarilumab, STAT-IN-1, and IL-1RA reduced CDKN2A expression by trend.ConclusionOur results demonstrate that complement activation and consequent TCC deposition is associated with chondrosenescence in age-related and trauma-induced OA. We provided evidence that the SIPS-like phenotype is more likely induced by TCC-mediated cytokine release rather than oxidative stress. Overall, targeting TCC formation could be a future approach to attenuate OA progression.
Case report: Movement-related neuroplasticity in a patient after spinal cord injury in response to task-oriented bimanual training
Authors: Ma Di , Zeng Roy Rongyue , Chan Sofina Sy , Pan Yu , Zhang Jack Jiaqi 
Published: January 2025

BackgroundBimanual motor training is an effective neurological rehabilitation strategy. However, its use has rarely been investigated in patients with paralysis caused by spinal cord injury (SCI). Therefore, we conducted a case study to investigate the effects of robot-assisted task-oriented bimanual training (RBMT) on upper limb function, activities of daily living, and movement-related sensorimotor activity in a patient with SCI.MethodsA patient with bilateral upper limb paresis due to incomplete cervical SCI underwent 20 sessions of RBMT. Functional recovery was measured using clinical scales for upper limb motor function and activities of daily living. Training-induced neuroplasticity was evaluated using event-related desynchronization (ERD) induced by movement of the right hand (the more affected side), recorded on the electroencephalogram (EEG).ResultsRBMT improved the patient’s upper limb motor function and activity independence. At baseline, our EEG paradigm demonstrated an ipsilateral predominance of movement-related ERD responses over the sensorimotor cortex (SMC) in relation to the moving hand. Following the RBMT, the ERD pattern shifted from being predominantly ipsilateral to a contralateral allocation.ConclusionThe present case study provides preliminary evidence to support the therapeutic use of RBMT to restore upper limb function in patients with incomplete SCI. The recovery of function following SCI might be related to the rebalancing of sensorimotor activation.
Validity of the Alberta Infants Motor Scale in Norwegian infants aged 6–9 months through comparison with Canadian and Dutch scores
Authors: Göthner Anniken , Riiser Kirsti , Tveten Kine Melfald 
Published: January 2025

IntroductionThe Alberta Infant Motor Scale (AIMS) is widely used to assess infant motor development but has shown limited cross-cultural validity in various populations. The distribution of the original AIMS scores has not been cross-culturally validated for Norwegian infants. This study aimed to evaluate the applicability of the Canadian AIMS norm reference for Norwegian infants aged 6–9 months and compare their percentile rankings with the Canadian and Dutch norms.MethodsIn this cross-sectional study, AIMS scores from a sample of 189 Norwegian infants aged 6–9 months were compared to the Canadian and Dutch norms. Total raw scores from the Canadian norms were compared to those of the Norwegian sample, and the percentiles of the Canadian and Dutch sample were compared to tentative Norwegian percentiles.ResultsNorwegian infants aged 6–9 months consistently scored lower on the AIMS than their Canadian counterparts (p &lt; 0.001), with 81% scoring at or below the 50th percentile and 18% falling at or below cut-off indicating possible motor delay. Using the Dutch norms, 20% of the Norwegian sample scored at or below the 50th percentile, while only 1% scored at or below the cut-off. A comparison of the percentile ranks showed that Canadian norms had the highest ranks for all age groups, followed by the Norwegian sample and subsequently the Dutch norms. The observed difference is considered clinically significant.ConclusionNeither Canadian nor Dutch AIMS norms are valid for Norwegian infants due to the Canadian norms being too stringent and the Dutch norms being too lenient. A thorough cross-cultural validation for infants 0–18 months to establish Norwegian-specific AIMS norms is recommended.
DNA methylation inhibitors adverse reaction characteristic analysis: an analysis based on the European spontaneous adverse event reporting system
Authors: Zhang Xia , Liu Yuyu , Hou Qingwang , Guo Yongxin , He Youfu 
Published: January 2025

IntroductionDNA methylation inhibitors have been approved for the prevention of Acute Myeloid Leukemia (AML), and their safety profile is not fully characterized. This study was aimed at evaluating the adverse drug reactions (ADRs) of DNA methylation inhibitors by analyzing the individual case safety reports (ICSRs) collected in the EudraVigilance (EV) database.Materials and methodsThe EV database managed by the European Medicines Agency was adopted. The standardized medical terminology set MedDRA was utilized. The ICSRs data of DNA methylation inhibitors for the treatment of acute myeloid leukemia originated from the EV database (2005–2024). A descriptive exploration of the combined data from EV was undertaken to assess the age, gender of patients, severity and outcome of ADR, event year, geographical origin and the qualification of the reporting source. A comprehensive assessment was made for severe ADR cases. By means of the Reporting Odds Ratio (ROR) and 95% Confidence Interval (CI), a non-proportional analysis was made for MedDRA® SOC in DNA methylation inhibitors. Statistical analysis was executed with SPSS version 23.0, and p &lt; 0.05 was regarded as statistically significant.ResultThe study reveals that reports related to AZACITIDINE increased from 2005 to 2023, with a slight decline in 2024, while those for DECITABINE have been on the rise since 2007. ICSRs were associated with a majority of males and individuals aged 65–85. Healthcare professionals frequently reported ICSRs related to DNA methylation inhibitors. A significant portion of these ICSRs were serious and completely resolved. The most common ADRs were identified, and certain ADRs had a higher reporting probability with AZACITIDINE (e.g., Febrile neutropenia, Anamia, etc.) and others with DECITABINE (e.g., Myelosuppression, Thrombocytopenia, etc.).ConclusionThe analysis regarding ADRs of DNA methylation inhibitors was consistent with the literature information disclosed. AZACITIDINE and DECITABINE each have ADRs with a high probability of being reported. Although the study has the advantage of using the database, it is limited by the spontaneous reporting system. Future improvements are needed to accurately evaluate the safety of the drugs.