bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of Comprehensive Genomic Profiling in Clinical Decision-Making in Oncology: A Systematic Review
Authors: Limaye Sewanti , Deshmukh Jayesh , Rohatagi Nitesh , Prabhash Kumar , Rauthan Amit , Singh Shambhavi , Kumar Arun 
Published: January 2025

ABSTRACT
Biologic factors limiting responsiveness to matched targeted therapies include genomic heterogeneity and complexity. Advanced tumors with unique molecular profiles can be studied by comprehensive genomic profiling (CGP) and enhance patient outcomes using principles of precision medicine. The clinical utility of CGP across all cancer types and different therapeutic interventions using overall survival (OS) and progression-free survival (PFS) data was studied in this systematic literature review. Randomized controlled, nonrandomized, and observational studies conducted in adult patients with advanced cancer, dated up to September 2022, were searched from PubMed and EMBASE databases following PRISMA guidelines. Of 14 CGP studies, 7 (50%) and 9 (64%) reported OS and PFS as an outcome, respectively. Improved OS and PFS were reported when CGP guided treatment decisions, but its clinical utility varied among cancer types. Treatments were assigned based on matching scores and with the involvement of molecular tumor board (MTB) enhanced OS and PFS. Patients following MTB recommendations had superior treatment outcomes compared with those on physician’s choice regimens. CGP clinically benefited patients with genomically matched therapies and yielded better clinical outcomes regardless of cancer type. Further, uniform clinical value-based ranking of actionable mutations can encourage oncologists to use CGP tests for patients.
ТЕПЛОВЫЕ ПРОЦЕССЫ ПРИ ИК-ОБЛУЧЕНИИ ВОДЫ: ЭКСПЕРИМЕНТ И МОДЕЛЬ
Authors: Сайко Д.С. , Андреев Д.Г. , Титов С.А. , Корепанов В.И. 
Published: January 2025

проведено экспериментальное исследование поглощения водой инфракрасного излучения, получены кривые зависимости температуры от времени и глубины положения двух датчиков относительно поверхности. Датчики были размещены на поплавках с таким условием, чтобы положение верхнего датчика было 0,5 мм от поверхности. Расстояние между термопарами было фиксировано и составляло 3 мм. Проведено моделирование тепловых процессов в образце. Для описания тепловых потоков в жидкости используется стандартная модель – уравнение теплопроводности с граничными условиями Ньютона-Рихмана. Для неоднородного уравнения теплопроводности с краевыми условиями третьего типа для полубесконечной среды с неоднородностью экспоненциального вида ранее было получено точное решение, которое используется для описания процессов в приповерхностной области при относительно малой длительности эксперимента. Проведено сравнение модели с экспериментом путем процедуры оптимизации входных параметров модели. Показано, что использование модели приводит, при высокой интенсивности инфракрасного (ИК)-облучения поверхности воды, к наблюдаемой зависимости температуры от времени и координаты, если полагать коэффициент теплопроводности в несколько раз большим табличного значения. В этом случае модель показывает, что в приповерхностной области толщиной порядка микрометра при высокой интенсивности облучения образца возникает инверсный тепловой поток, направленный к поверхности. Обсуждаются результаты моделирования и границы применения модели
the paper presents an experimental study of infrared absorption by the water, and temperature versus time and immersion depth curves of the two thermal sensors were obtained. The sensors were placed on floats so that the upper sensor was 0.5 mm from the surface. The distance between the thermocouples was fixed at 3 mm. Modeling of thermal processes in the sample was carried out. To describe heat flows in the liquid, a standard model is used - the heat conduction equation with Newton-Richman boundary conditions. For an inhomogeneous heat conduction equation with boundary conditions of the third type for a semi-infinite medium with exponential inhomogeneity, the authors previously obtained an exact solution, which is used to describe processes in the near-surface region with a relatively short duration of the experiment. The model is compared with the experiment by means of the optimization procedure of the input parameters of the model. It is shown that the use of the model leads, at high intensity of IR irradiation of the water surface, to the observed dependence of temperature on time and coordinate, if we assume the thermal conductivity coefficient to be several times greater than the tabulated value. In this case, the model shows that in the near-surface region with a thickness of the order of a micrometer at high intensity of irradiation of the sample, an inverse heat flow directed to the surface occurs. The results of modeling and the limits of application of the model are discussed
МЕТОДИКА ОПТИМИЗАЦИИ ХРАНЕНИЯ ДАННЫХ НА БАЗЕ ФЛЭШ-ПАМЯТИ С УЧЕТОМ АНАЛИЗА ПОРОГОВОГО НАПРЯЖЕНИЯ
Authors: Башкиров А.В. , Хорошайлова М.В. , Демихова А.С. 
Published: January 2025

разработана методика регулирования хранения данных с учетом анализа порогового напряжения для увеличения срока службы флэш-памяти. Основная идея заключается в том, что во время операции считывания модуляция условий смещения позволяет анализировать уровень порогового напряжения (Vth). Могут быть обнаружены биты со слабым уровнем заряда при использовании кодов исправления ошибок (ECC), оперативного резервирования и анализа Vth. Для этой цели разработана модель массива памяти, использующая ячейки для обеспечения надежности реализации использовании стандартного кода исправления ошибок. Данная методика позволяет разделить страницы, хранящихся во флэш-памяти, на две группы в зависимости от частоты записи страниц и применить наиболее подходящих средства управления доступа к двум различным группам флэш-страниц/блоков. Данная методика позволяет устранить значительное количество ненужных обновлений и значительно увеличивает срок службы флэш-памяти. Приведена архитектура, которая повышает надежность ячейки памяти, и позволяет заменить ошибочную страницу избыточной страницей, как только будет обнаружена ошибка. Проведенное моделирование показывает, что с использованием кода четности, который может обнаруживать только одну ошибку, коррекция ошибок с анализом порогового напряжения может исправить до одной ошибки, что позволяет улучшить среднее время работы до отказа памяти в 4,7 раза в 2-мегабитном массиве с 32 битами на слово
in this article, a methodfor regulating data storagehas been developed, taking into account the analysisof threshold voltage to increase the servicelife of flash memory. The main idea is that duringthe reading operation, the modulation of the bias conditions allows you to analyze the threshold voltage level (Vth). Low-charge batteries can be detected using error correction codes (ECC), operational redundancy and Vth analysis. For this purpose, a memory array model has been developed that uses cells to ensure reliability when usinga standard error correction code. This technique allows you to divide the pages stored in flash memory into two groups depending onthe frequency of page recording and applythe most appropriate access controls to two different groups of flash pages/blocks. This technique eliminates a significant numberof unnecessary updates and significantly increases the service life of flash memory. An architecture is provided that increasesthe reliability of the memory cell, and allowsyou to replace an erroneous pagewith a redundant page as soon as an error is detected. The simulation shows that using a parity code that can detect only one error, error correction with threshold voltage analysis can correct up to one error, which improvesthe average operating time to memory failure by 4.7 times in a 2-megabit array with 32 bits per word
ПЕЧАТНАЯ ЛОГОПЕРИОДИЧЕСКАЯ АНТЕННА ДЛЯ ШИРОКОПОЛОСНОГО ПЕЛЕНГАЦИОННОГО КОМПЛЕКСА
Authors: Егорова Е.Д. , Ищенко Е.А. , Медведев А.Е. , Пацев Д.В. , Фёдоров С.М. 
Published: January 2025

рассматривается печатная широкополосная антиподальная логопериодическая антенна, которая предназначена для реализации широкополосного пеленгационного комплекса. Предлагаемая конструкция антенны обладает простотой реализации, повторяемостью, а также стабильностью характеристик в широком диапазоне рабочих частот. Для реализации был выбран диапазон рабочих частот 900-1400 МГц, что позволяет обеспечить максимально широкое перекрытие диапазона, в котором работают автоматизированные роботизированные комплексы. Приводятся результаты электродинамического моделирования антенны, а также измерения характеристик макета. Макет выполнялся на основе двустороннего фольгированного диэлектрика Fr-4 толщиной 1 мм, что позволяет обеспечить малые размеры антенны, а также большую прочность. Полученный макет использовался для измерения диапазона рабочих частот с применением векторного анализатора цепей, а также для измерения диаграммы направленности. Полученные результаты показывают высокую корреляцию результатов измерений и моделирования, что особенно важно для антенных систем пеленгационных комплексов. Также особое внимание в работе было уделено позиции фазового центра антенны, так как он оказывает влияние на измерение характеристик электромагнитного поля, что особенно важно в задачах пеленгации источников электромагнитного излучения
the paper considers a printed broadband antipodal logoperiodic antenna, which is designed to implement a broadband direction finding system. The proposed antenna design has simplicity of implementation, repeatability, as well as stability of characteristics over a wide range of operating frequencies. The operating frequency range 900-1400 MHz was selected for implementation, which allows for the widest possible overlap of the range in which automated robotic complexes operate. The article presents the results of electro-dynamic modeling of the antenna, as well as measurements of the characteristics of the layout. The layout was made on the basis of a double-sided foil dielectric Fr-4 with a thickness of 1 mm, which makes it possible to ensure the small size of the antenna, as well as greater strength. The resulting layout was used to measure the operating frequency range using a vector circuit analyzer, as well as to measure the radiation pattern. The obtained results show a high correlation of measurement and simulation results, which is especially important for antenna systems of direction finding complexes. Also, special attention was paid to the position of the phase center of the antenna, since it affects the measurement of the characteristics of the electromagnetic field, which is especially important in the problems of direction finding of electromagnetic radiation sources
METODOLOGIAS ATIVAS NO ENSINO MÉDICO EM FORMATO REMOTO EMERGENCIAL
Authors: Martins Frankly Eudes Sousa , Gomes Francisco Vinícius Ferreira , Gonçalves Fabiana Barbosa 
Published: January 2025

O ensino remoto emergencial foi proposto indistintamente entre os cursos de graduação com diferentes currículos empregados. O presente trabalho objetivou relatar e refletir os desafios, as potencialidades e as estratégias usadas na implementação do ensino remoto emergencial em um curso de graduação em medicina com currículo baseado em metodologias ativas. As reflexões aqui tecidas são baseadas em observação participante durante a vivência do estágio à docência do Programa de Mestrado Profissional em Educação, Trabalho e Inovação em Medicina da EMCM/UFRN. A experiência destacou o uso de plataformas e ferramentas virtuais em métodos ativos de ensino na graduação em medicina, o que pode ser complementar ao ensino prático, especialmente quando o acesso a ambientes clínicos reais for restrito. Ademais, as metodologias ativas em ambiente virtual imprimiram dinamicidade, motivação e troca de saberes no percurso formativo em medicina, bem como o aprendizado significativo e qualificação profissional na pós-graduação.
Pengaruh Perputaran Kas, Perputaran Piutang dan Perputaran Persediaan Terhadap Profitabilitas Pada Perusahaan Sub Sektor Food and Beverages Yang Terdaftar di Bursa Efek Indonesia Tahun 2017-2022
Authors: Kusumawardhani Aninditha Putri , Rusnendar Elan , Noviyanti Lina 
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh dan seberapa besar pengaruh perputaran kas, perputaran piutang dan perputaran persediaan terhadap profitabilitas pada perusaahaan sub sektor food and beverages yang terdaftar di Bursa Efek Indonesia Tahun 2017-2022 secara parsial dan simultan. Data sekunder yang dipakai dalam penelitian ini adalah data dari laporan keuangan perusahaan sub sektor food and beverages yang terdaftar di Bursa Efek Indonesia pada tahun 2027-2022. Jumlah sampel yang digunakan sebanyak 54 laporan keuangan dari 9 perusahaan food and beverages selama enam tahun. Metode yang digunakan dalam penelitian ini adalah analisis kuantitatif dengan metode deksriptif dan verifikatif. Teknik pengujian data menggunakan uji asumsi klasik, uji regresi linier berganda, uji koefisien korelasi berganda, uji koefisien determinasi, uji parsial dan ujin simultan. Hasil dari penelitian ini menunjukan bahwa secara parsial variabel perputaran kas berpengaruh terhadap profitabilitas. perputaran piutang tidak berpengaruh terhadap profitabilitas. Perputaran persediaan tidak berpengaruh terhadap profitabilitas. Secara simultan perputaran kas, perputaran piutang dan perputaran persediaan berpengaruh terhadap profitabilitas.
Peningkatan Pengetahuan Pentingnya Keamanan Pangan dalam Sistem Produksi Yoghurt Drink Melalui Sosialisasi di UKM Yoghurt Sehati Banyumas
Authors: Latifasari Nurul , Syifa Fikra Titan , Agustia Friska Citra , Carantia Raharditya  , Septi Adi Cahyani  , Poppy Ambar Rini  
Published: January 2025

Keamanan pangan merupakan aspek kritis dalam produksi makanan dan minuman, terutama bagi UKM yang berfokus pada olahan minuman seperti yoghurt. Undang-undang RI No. 7 Tahun 1996 menekankan pentingnya mencegah kontaminasi biologi, fisik, dan kimia yang dapat merugikan kesehatan manusia. UKM Yoghurt Sehati di Banyumas, menghadapi tantangan terkait minimnya pengetahuan tentang pentingnya penerapan keamanan pangan pada produk yogurt yang diproduksi. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman dan kesadaran karyawan mengenai pentingnya keamanan pangan melalui sosialisasi yang mencangkup identifikasi titik kritis produk dan metode pencegahan kontaminasi. Metode yang digunakan meliputi observasi, pre-test, pemaparan materi, dan post-test. Hasil kegiatan menunjukkan peningkatan pengetahuan yang cukup signifikan mengenai pentingnya keamanan pangan yang perlu diterapkan pada sistem produksi yogurt drink, dengan nilai pre-test rata-rata sebesar 60% meningkat menjadi 100% setelah dilakukan sosialisasi. Peningkatan pengetahuan ini diharapkan dapat meningkatkan kualitas dan keamanan produk yoghurt yang dihasilkan oleh UKM Yoghurt Sehati Banyumas.
The Lack of RR Lyrae Variables in Ultrafaint Dwarf Galaxy Sextans II
Authors: Ngeow Chow-Choong , Bhardwaj Anupam 
Published: January 2025

Abstract
RR Lyrae in ultrafaint dwarf (UFD) galaxies, if found, would be valuable to constrain the distances of these UFD. In this work, we report our search of RR Lyrae in a recently discovered UFD—Sextans II. Based on multiband (griz) time-series archival DECam imaging data, we do not find any RR Lyrae in Sextans II. On the contrary, the sparse multiband DECam light curves allowed recovery of a known foreground RR Lyrae, BB Sex, which happened to fall within the DECam images, and its pulsation period was correctly identified. Therefore, it is possible that Sextans II lacks RR Lyrae, similar to several other fainter UFDs (with M

V
≳ −5.0 mag) that do not have RR Lyrae.
Closing the Stellar Labels Gap: Stellar Label independent Evidence for [α/M] Information in Gaia BP/RP Spectra
Authors: Laroche Alexander , Speagle 沈 Joshua S. 佳士 
Published: January 2025

Abstract
Data-driven models for stellar spectra that depend on stellar labels suffer from label systematics which decrease model performance: the stellar labels gap. To close the stellar labels gap, we present a stellar label independent model for Gaia BP/RP spectra. We develop a novel implementation of a variational auto-encoder, which learns to generate an XP spectrum and accompanying scatter without relying on stellar labels. We demonstrate that our model achieves competitive XP spectra reconstructions in comparison to stellar label dependent models. We find that our model learns stellar properties directly from the data itself. We then apply our model to XP/APOGEE giant stars to study the [α/M] information in Gaia XP. We provide strong evidence that the XP spectra contain meaningful [α/M] information by demonstrating that our model learns the α-bimodality, without relying on stellar label correlations for stars with T
eff < 5000 K, while also being sensitive to the anomalous abundances of Gaia-Enceladus stars. We have publicly released our trained model, codebase and data. Importantly, our stellar label independent model can be implemented for any and all XP spectra because our model's performance scales with training object density, not training label density.
Early Results from GLASS-JWST. XXV. Electron Density in the Interstellar Medium at 0.7 ≲ z ≲ 9.3 with NIRSpec High-resolution Spectroscopy*
Authors: Li Sijia , Wang Xin , Chen Yuguang , Jones Tucker , Treu Tommaso , Glazebrook Karl , He Xianlong , Henry Alaina , Meng Xiao-Lei , Morishita Takahiro , Roberts-Borsani Guido , Yang Lilan , Yu Hao-Ran , Calabrò Antonello , Castellano Marco , Leethochawalit Nicha , Metha Benjamin , Nanayakkara Themiya , Roy Namrata , Vulcani Benedetta 
Published: January 2025

Abstract
The electron density (n
e) of the interstellar medium (ISM) in star-forming galaxies is intimately linked to star formation and ionization condition. Using the high-resolution spectra obtained from the JWST Near-Infrared Spectrograph (NIRSpec) microshutter assembly (MSA) as part of the GLASS-JWST program, we have assembled the largest sample to date (34 galaxies) with individual n
e measurements derived from the [O ii] λλ3726, 29 and/or [S ii] λλ6718, 32 doublets at 0.7 ≲ z ≲ 9.3. The gravitational lensing magnification by the foreground A2744 cluster allows us to probe n
e in galaxies with stellar masses (M
*) down to ≃107.5
M
⊙ across the entire redshift range. Our analysis reveals that the [O ii] flux ratios are marginally anticorrelated with a specific star formation rate (sSFR) within a 1σ confidence interval, whereas the [S ii] flux ratios show no significant correlation with sSFR. Despite a clear correlation between sSFR and redshift within our sample, we find no apparent redshift evolution of n
e at z ≃ 1–9. Our data set also includes 13 galaxies where n
e can be measured from both [O ii] and [S ii]. Contrary to findings at lower redshifts, we observe considerable scatter in n
e measurements from [O ii] and [S ii], indicating a complex gaseous environment with significant variations in n
e in high-redshift galaxies. This work highlights the unique capability of JWST NIRSpec/MSA high-resolution spectroscopy to characterize the detailed physical properties of the ISM in individual high-redshift galaxies.
A Possible Metal-dominated Atmosphere below the Thick Aerosols of GJ 1214 b Suggested by Its JWST Panchromatic Transmission Spectrum
Authors: Ohno Kazumasa , Schlawin Everett , Bell Taylor J. , Murphy Matthew M. , Beatty Thomas G. , Welbanks Luis , Greene Thomas P. , Fortney Jonathan J. , Parmentier Vivien , Edelman Isaac R. , Mehta Nishil , Rieke Marcia J. 
Published: January 2025

Abstract
GJ 1214b is the archetype sub-Neptune for which thick aerosols have prevented us from constraining its atmospheric properties for over a decade. In this study, we leverage the panchromatic transmission spectrum of GJ 1214b established by the Hubble Space Telescope (HST) and JWST to investigate its atmospheric properties using a suite of atmospheric radiative transfer, photochemistry, and aerosol microphysical models. We find that the combined HST, JWST/NIRSpec, and JWST/MIRI spectrum can be well explained by atmospheric models with an extremely high metallicity of [M/H] ∼ 3.5 and an extremely high haze production rate of F
haze ∼ 10−8 to 10−7 g cm−2 s−1. Such high atmospheric metallicity is suggested by the relatively strong CO2 feature compared to the haze absorption feature or the CH4 feature in the NIRSpec-G395H bandpass of 2.5–5 μm. The flat 5–12 μm MIRI spectrum also suggests a small scale height with a high atmospheric metallicity that is needed to suppress a prominent ∼6 μm haze feature. We tested the sensitivity of our interpretation to various assumptions for uncertain haze properties, such as optical constants and production rate, and all models tested here consistently suggest extremely high metallicity. Thus, we conclude that GJ 1214b likely has a metal-dominated atmosphere where hydrogen is no longer the main atmospheric constituent. We also find that different assumptions for the haze production rate lead to distinct inferences for the atmospheric C/O ratio. We stress the importance of high-precision follow-up observations to confirm the metal-dominated atmosphere, as it challenges the conventional understanding of interior structure and evolution of sub-Neptunes.
The Energy Sharing Timescale in an Analytic Framework for Common Envelope Hydrodynamics
Authors: Everson Rosa Wallace , MacLeod Morgan , Ramirez-Ruiz Enrico 
Published: January 2025

Abstract
We propose a new predictive theory for the analysis of common envelope (CE) events that incorporates the effects of relevant hydrodynamical processes into a simple analytical framework. We introduce the ejection and dynamical parameters ξ and β, which define whether envelope ejection is energetically or hydrodynamically favorable, respectively, during CE inspiral. When combined, these parameters offer a detailed narrative of how inspiral begins, proceeds, and ends that is consistent with preliminary comparisons to 3D hydrodynamical models. This physically motivated framework impacts predictions for CE outcomes, especially for systems that have energy excess, and offers promise as a potential alternative for the treatment of CEs in binary population synthesis.
No Sky Too High, No Sea Too Rough: Qualitative Investigation of Resilience and Suicide in Special Operations Forces Service Members
Authors: Rocklein Kate , Paun Olimpia , Hamilton Rebekah , Shattell Mona , Held Philip , Chandler Genevieve , Viola Steve 
Published: January 2025

Purpose
To investigate resilience in American Special Operations Forces (SOF) personnel.

Method
A qualitative descriptive exploratory design was used to interview Special Forces and Navy SEAL participants about their perspectives on and experiences of resilience. Assumptions that high resilience inversely correlates with suicide risk in SOF drove our primary research questions and study focus. Questions were based on Holling's theory of ecological resilience.

Results
Participants provided insightful and detailed data of their resilience and were often self-effacing or self-critical. Responses indicated that although quite resilient, SOF personnel express their resilience in ways known to become pathological and precipitate suicidality if left undetected. Extracted subthemes indicated commitment to others over self and a nexus of trait variables linked to suicidality. Estimated neurotrauma from repetitive blast exposures should be incorporated in future models.

Conclusion

Findings challenge prevailing beliefs that dysfunctional behaviors and suboptimal resilience drive SOF suicide. Results herein justify future research and changes to command postures and U.S. Department of Defense initiatives regarding relationships between and among variables of resilience, neurotrauma, and suicide in SOF. [
Journal of Psychosocial Nursing and Mental Health Services, xx
(xx), xx–xx.]