bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS BALANCED SCORECARD DALAM PENGUKURAN KINERJA RADIO REPUBLIK INDONESIA KUPANG
Authors: Wutun Maria Mawarni 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui bagaimana pencapaian kinerja RRI Kupang dengan metode Balanced Scorecard sehingga mampu mempertahankan bidang jasa yang dijalankan hingga saat ini. Teknik pengumpulan data adalah wawancara dan dokumentasi. Sumber data yang digunakan adalah data primer dan data sekunder. Teknik analisis data yang digunakan adalah dengan Balanced Scorecard yaitu dengan tahapan mengetahui visi dan misi RRI Kupang, identifikasi sasaran strategi dan KPI, melakukan validasi strategis dan KPI, pendefinisian sasaran strategi dan KPI ke dalam Balanced Scorecard.
Berdasarkan penelitian yang dilakukan pada LPP RRI Kupang, empat (4) perspektif konsep Balanced Scorecard (pertumbuhan dan pembelajaran, proses bisnis internal, pelanggan serta keuangan) ditemukan sebelas (11) sasaran strategi untuk melakukan misi demi tercapainya visi yang direncanakan yaitu meningkatkan skill pegawai, meningkatkan kesejahteraan hidup pegawai, meningkatkan kepuasan kerja pegawai, proses inovasi, proses operasi, meningkatkan jumlah pendengar, meningkatkan kepuasan pendengar, kesesuaian perencanaan dan penganggaran, efektivitas pelaksanaan kegiatan, kepatuhan terhadap regulasi dan efisiensi pelaksanaan kegiatan. Dari sebelas sasaran strategis diperoleh 20 Key Performance Index.
LPP RRI Kupang diharapkan terus menjaga sasaran strategi dan indikator yang sudah ada serta menemukan sasaran strategi dan indikator baru guna mempertahankan dan meningkatkan kinerja maupun memuaskan keinginan para pendengar setia, terus membuat peta strategi berdasarkan sasaran strategi dan indikator yang sudah ada serta berdasarkan sasaran strategi dan indikator baru, harus tetap menjaga hubungan kerja yang baik antarbidang sehingga empat keunggulan yang diharapkan dari Balanced Scorecard (komperhensif, koheren, seimbang dan terukur) terus tercapai seperti yang terjadi sekarang.
ANALISIS PENGARUH BIAYA OPERASIONAL PER PENDAPATAN OPERASIONAL (BOPO),NON PERFORMING LOAN (NPL), PERTUMBUHAN EKONOMI DAN INFLASI TERHADAP RETURN ON ASSET (ROA) (Studi Kasus Pada PT Bank Mandiri [Persero] Tbk Indonesia)
Authors: TAE ROMUALDUS EMANUEL , MANEK AQUIDOWARIS MANEK 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui pengaruh Biaya Operasional Per Pendapatan Operasional (BOPO), Non Performing Loan (NPL), Pertumbuhan Ekonomi, dan Infasi terhadap Return On Asset (ROA) pada PT Bank Mandiri (Persero) Tbk Indonesia. Teknik pengumpulan data yang digunakan adalah dokumentasidan observasi. Populasi dalam penelitian ini adalah PT bank Mandiri (Persero) Tbk Indonesia, dan sampel yang diteliti sebanyak 31 responden (31 triwulan dari variabel-variabel penelitian) dengan teknik sampling yang digunakan adalah purposive sampling. Teknik analisis data yang digunakan adalah : deskriptif dan inferensial dengan alat analisis regresi linear sederhana dan regresi linear berganda. Hasil pada penelitian menunjukkan bahwa secara parsial variabel BOPO (X1) dan NPL (X2) berpengaruh negatif dan signifikan terhadap ROA Bank Mandiri; Pertumbuhan Ekonomi (X3), berpengaruh negatif dan tidak signifikan terhadap ROA Bank Mandiri; sedangkan Inflasi (X4) berpengaruh posetif dan tidak signifikan terhadap ROA Bank Mandiri. Secara simultan variabel BOPO, NPL, Pertumbuhan Ekonomi dan Inflasi berpengaruh terhadap ROA Bank Mandiri.
ANGGARAN PENDAPATAN UNIVERSITAS DALAM PERSPEKTIF PENGELOLAAN DAN PEMANFAATANNYA
Authors: Aksa Adi Faisal , Manane Desmon Redikson 
Published: April 2023

Abstract: Revenue budget is the amount of money earned and must be spent in a certain period to carry out a program or activity. In the realization or use of the budget, it is necessary to see how the perspective of management and utilization is from student discipline, income planning, and socialization. This study uses a regression analysis method with a number of lecturers and employees as samples. The results of this study reveal that to increase budget realization, it is necessary to control or manipulative student discipline, income planning, and socialization by providing herregistration socialization to students and planning income according to the right time so that it contributes more to increasing budget realization.

Abstrak: Anggaran pendapatan merupakan sejumlah uang yang didapatkan dan harus dihabiskan dalam periode tertentu untuk melaksanakan suatu program atau kegiatan. Dalam realisasi atau penggunaan anggaran perlu dilihat bagaimana perspektif pengelolaan dan pemanfaatannya dari kedisiplinan mahasiswa, perencanaan pendapatan, dan sosialisasi. Penelitian ini menggunkan metode analisis regresi dengan sejumlah dosen dan karyawan sebagai sampel. Hasil penelitian ini mengungkapkan bahwa untuk meningkatkan realisasi anggaran maka perlu adanya kontrol atau manipulatif kedisiplinan mahasiswa, perencanaan pendapatan, dan sosialisasi dengan cara memberikan sosialisasi herregistrasi kepada mahasiswa serta merencanakan pendapatan sesuai dengan waktu yang tepat sehingga lebih memberikan kontribusi bagi peningkatan realisasi anggaran.
Diagnostic efficacy of conventional cytological smears and cell block of ascitic fluid for detection of malignant cell
Authors: Nowsher Md Neaz , Karim Syeda Noorjahan , Karim Rezwana , Rahman DM Arifur , Barua Ashim Ranjan 
Published: April 2023

Introduction: For identification of malignant cells in effusion, cell block is a simple, inexpensive method and no additional expatriation is needed. In the identification of malignant cells in effusion, its differentiation from cells showing reactive and degenerative changes were diagnostic difficulties in some of the cases. The cell block method yielded more cellularity and provided better morphological details. Multiple sections could be obtained for special stain and immunohistochemistry when required.
Methods: This cross-sectional observational study was carried out at the Department of Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; from March, 2017 to December, 2018. The sample size was 101 and the study material was ascitic fluids of clinically suspected malignancy cases. Conventional smears and cell block were prepared in every cases. Both conventional and cell block slides were scored according to Miar’s point scoring system and analyzed according to diagnostic categories.
Results: By conventional smear, 86 cases were diagnosed as negative for malignancy, four cases were diagnosed as suspicious for malignancy and remaining 11 cases were diagnosed as positive for malignancy. After analyzing cell blocks, three more malignant cases were diagnosed, which had been diagnosed as suspicious for malignancy by conventional smear. Cell block technique showed significant differences in the diagnosis of suspicious cases of effusion in comparison to conventional smear (p<0.05)
Conclusion: Cell Block technique could be considered as a useful adjunct in evaluating malignant cells in malignant ascitic effusion for a final cytodiagnosis, along with the routine conventional method.
Mediscope 2023;10(1): 01-09
UMA PESQUISA BIBLIOGRÁFICA SOBRE AS TECNOLOGIAS INCLUSIVAS PARA AS PESSOAS COM DEFICIÊNCIA NA INDÚSTRIA 4.0
Authors: Rosa Josely Cristiane , Modesto Bertoldi Roney 
Published: April 2023

Este estudo buscou apresentar as tecnologias inclusivas para as pessoas com deficiência, considerando a Indústria 4.0. Para tanto, a pesquisa apresentou um breve panorama sobre a deficiência no Brasil, compreendendo a legislação prevista para as pessoas com deficiência, além de entender as especificidades da Indústria 4.0 e as tecnologias assistivas. Do ponto de vista metodológico, a pesquisa foi caracterizada em bibliográfica. Os resultados evidenciaram que muitas tecnologias inclusivas estão sendo criadas, gerando novas oportunidades para as pessoas com deficiência, como por exemplo, os recursos de acessibilidade ao computador, os sistemas de controle de ambiente, os projetos arquitetônicos para acessibilidade, as órteses e próteses, auxílios para cegos ou com visão subnormal, entre outros. Nós compreendemos que a oportunidade é um dos principais fatores para gerar confiança na inclusão de pessoas com deficiência no mercado de trabalho e que as novas tecnologias da Indústria 4.0, vem para facilitar este processo de integração.
Palavras-Chave: Tecnologia Assistiva. Indústria 4.0. Inclusão 4.0.

Abstract
This study sought to present inclusive technologies to people with disabilities, considering Industry 4.0. Therefore, the research presented a brief overview of disability in Brazil, including the legislation provided for people with disabilities, in addition to understanding the specifics of the Industry 4.0 and assistive technologies. From the methodological point of view, the research was characterized as bibliographic. The results showed that many inclusive technologies are being created, creating new opportunities for people with disabilities, such as computer accessibility resources, environment control systems, architectural projects for accessibility, orthotics and prostheses, aids for the blind or those with low vision, among others. We understand that opportunity is one of the key factors to generate confidence in the inclusion of people with disabilities in the job market and that the new technologies of Industry 4.0, come to facilitate this integration process.
Keywords: Assistive Technology. Industry 4.0. Inclusion 4.0.
Eficácia de inseticidas alternativos e biológicos sobre Sitophilus zeamais (Coleoptera: Curculionidae) em grãos de milho
Authors: Cemin Marina Ferreira Rosa , Spazzin Magdalena Pomina , Bellon Patrícia Paula 
Published: April 2023

O estudo objetivou avaliar a eficiência de inseticidas alternativos e biológicos sobre a população de Sitophilus zeamais em grãos de milho. A pesquisa foi conduzida em delineamento inteiramente casualizado, contendo cinco tratamentos, terra de diatomácea (750 g/t), óleo de nim (10 ml/L), Beauveria bassiana (20 g/L) e fumo (10 ml/L), e nove repetições, sendo cada ensaio composto por 20 adultos. Para avaliação da atividade inseticida, amostras de grãos de milho, foram dispostas em potes plásticos submetidas aos tratamentos

. Os inseticidas foram polvilhados e pulverizados sobre os grãos de milho e posteriormente, cada amostra foi infestada com 20 adultos de Sitophilus zeamais, não sexados, com idade entre 10 e 15 dias. A mortalidade dos insetos foi avaliada em 48, 96, 144 e 240 h após a aplicação. A mortalidade total dos insetos foi corrigida pela fórmula de Schneider Orelli. Após, os dados foram submetidos ao teste não paramétrico de Kruskal-Wallis ao nível de significância de 5%. Havendo diferenças significativas entre os tratamentos, as medianas foram comparadas pelo teste de Dunn a 5% de probabilidade de erro. Somente o inseticida terra de diatomácea apresentou efeito significativo na mortalidade de Sitophilus zeamais para o terceiro dia (5,56%) e o sexto dia (84,21%) de exposição do produto. Os tratamentos nim, fumo e Beauveria bassiana, não interferiram na mortalidade do inseto, não diferindo estatisticamente da testemunha em nenhuma das datas de avaliação. O produto terra de diatomácea apresentou maior eficiência sobre Sitophilus zeamais, atingindo um percentual de 89,77% de mortalidade sobre os insetos.
Elevated Expression of miR-296 in Human Placentas and Serum Samples From Pregnancies With Preeclampsia
Authors: Zhu Dandan , Guo Ting , Xu Jie , Yuan Donglan , Lin Mei , Yang Minyan 
Published: April 2023

Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by widespread maternal endothelial dysfunction. Although clinical signs subside following delivery, long-term risks associated with PE include hypertension, stroke, and cardiovascular disease. MicroRNAs (miRNAs) are emerging as critical regulators of biological function, and while alterations to the miRNAs have been described in the context of pregnancy and PE, the postpartum implications of PE on miRNA expression are unknown. In the present study, we aimed to determine the clinical performance of miR-296 in PE.Methods: First, the clinical information and outcomes of all the participants were collected and analyzed. Afterward, the miR-296 expressions in the serum samples from healthy pregnant women and women with PE at different periods were detected using quantitative real-time polymerase chain reaction (qRT-PCR). Then, the receive operation characteristic (ROC) curve was used to determine the diagnostic value of miR-296 in PE. Finally, the at-term placentals were collected, the expressions of miR-296 in different groups were compared at first blood collection and at delivery.Results: In this study, we found that miR-296 expression was significantly increased in the placenta samples from PE patients compared with that in healthy controls both in early onset group (EOPE, p &lt; 0.01) and late onset group (LOPE, p &lt; 0.01). Furthermore, results of ROC analysis showed miR-296 might be a putative biomarker for early onset preeclampsia and late onset preeclampsia diagnosis with an area under the curve (AUC) of 0.84 (95% confidence interval 0.75–0.92) and 0.85 (95% confidence interval 0.77–0.93). Last but not the least, the expressions of miR-296 were significantly increased (p &lt; 0.05) in serum samples of EOPE and LOPE patients (p &lt; 0.001), and serum and placental levels of the miR-296 was positively correlated for EOPE (r = 0.5574, p &lt; 0.001) and LOPE (r = 0.6613, p &lt; 0.001) patients, respectively. Meanwhile, compared with those at first blood collection, the expression of miR-296 in EOPE (p = 0.05) and LOPE (p = 0.01) were significantly decreased at delivery.Conclusion: miR-296 may function as a putative diagnostic biomarker for PE and contribute to identifying at-risk mothers in pregnancy.
Exercises in activating lymphatic system on fluid overload symptoms, abnormal weight gains, and physical functions among patients with heart failure: A randomized controlled trial
Authors: Li Yuan , Meng Qingtong , Luo Biru , Li Minlu , Fang Jinbo , Allred Sarah R. , Fu Mei Rosemary 
Published: April 2023

BackgroundFluid overload remains a vexing problem in management of heart failure. The lymphatic system that plays the central role in fluid homeostasis has recently been explored as a potential target to counteract tissue fluid overload. The goal of the study was to evaluate the preliminary effects of exercises in activating lymphatic system on fluid overload symptoms, abnormal weight gains, and physical functions for patients with heart failure.Methods and resultsA pilot, pre- and post-test, randomized clinical trial was conducted to recruit a total of 66 patients who were randomized to receive either a 4-week The-Optimal-Lymph-Flow for Heart Failure (TOLF-HF) program or usual care alone. The primary outcome was the prevalence and burden of the fluid overload symptoms. Findings of the trial showed that the TOLF-HF intervention was effective in reducing the prevalence or burden of the majority of fluid overload symptoms. TOLF-HF intervention also demonstrated significant improvement in the outcomes of abnormal weight gains (MD: −0.82; 95% CI: −1.43 to −0.21; P = 0.010) and physical functions (F = 13.792, P &lt; 0.001).ConclusionsThe TOLF-HF program focusing on activating lymphatic system through the performance of therapeutic lymphatic exercises holds the promise as an adjuvant therapy for patients with heart failure to manage fluid overload symptoms, reduce abnormal weight gains, and improve physical functions. Future larger-scale study with longer duration of follow-up is needed.Clinical Trial Registrationhttp://www.chictr.org.cn/index.aspx, identifier ChiCTR2000039121.
Interpretable clinical phenotypes among patients hospitalized with COVID-19 using cluster analysis
Authors: Yamga Eric , Mullie Louis , Durand Madeleine , Cadrin-Chenevert Alexandre , Tang An , Montagnon Emmanuel , Chartrand-Lefebvre Carl , Chassé Michaël 
Published: April 2023

BackgroundMultiple clinical phenotypes have been proposed for coronavirus disease (COVID-19), but few have used multimodal data. Using clinical and imaging data, we aimed to identify distinct clinical phenotypes in patients admitted with COVID-19 and to assess their clinical outcomes. Our secondary objective was to demonstrate the clinical applicability of this method by developing an interpretable model for phenotype assignment.MethodsWe analyzed data from 547 patients hospitalized with COVID-19 at a Canadian academic hospital. We processed the data by applying a factor analysis of mixed data (FAMD) and compared four clustering algorithms: k-means, partitioning around medoids (PAM), and divisive and agglomerative hierarchical clustering. We used imaging data and 34 clinical variables collected within the first 24 h of admission to train our algorithm. We conducted a survival analysis to compare the clinical outcomes across phenotypes. With the data split into training and validation sets (75/25 ratio), we developed a decision-tree-based model to facilitate the interpretation and assignment of the observed phenotypes.ResultsAgglomerative hierarchical clustering was the most robust algorithm. We identified three clinical phenotypes: 79 patients (14%) in Cluster 1, 275 patients (50%) in Cluster 2, and 203 (37%) in Cluster 3. Cluster 2 and Cluster 3 were both characterized by a low-risk respiratory and inflammatory profile but differed in terms of demographics. Compared with Cluster 3, Cluster 2 comprised older patients with more comorbidities. Cluster 1 represented the group with the most severe clinical presentation, as inferred by the highest rate of hypoxemia and the highest radiological burden. Intensive care unit (ICU) admission and mechanical ventilation risks were the highest in Cluster 1. Using only two to four decision rules, the classification and regression tree (CART) phenotype assignment model achieved an AUC of 84% (81.5–86.5%, 95 CI) on the validation set.ConclusionsWe conducted a multidimensional phenotypic analysis of adult inpatients with COVID-19 and identified three distinct phenotypes associated with different clinical outcomes. We also demonstrated the clinical usability of this approach, as phenotypes can be accurately assigned using a simple decision tree. Further research is still needed to properly incorporate these phenotypes in the management of patients with COVID-19.
Population structure, genetic diversity and prolificacy in pishan red sheep under an extreme desert environment
Authors: Zhang Cheng-long , Zhang Jihu , Tuersuntuoheti Mirenisa , Chang Qianqian , Liu Shudong 
Published: April 2023

Extreme environmental conditions are a major challenge for livestock production. Changes in climate conditions, especially those that lead to extreme weather, can reduce livestock production. The screening of genes and molecular markers is of great significance to explore the genetic mechanism of sheep prolificacy traits in Taklimakan Desert environment. We selected healthy adult Pishan Red Sheep (PRS) and Qira Black Sheep (QR) which live in Taklimakan Desert environment, collected blood from jugular vein, extracted DNA, and prepared Illumina Ovine SNP50 chip. For PRS, linkage disequilibrium (LD) was calculated using the ovine SNP50 Beadchip and the effective population size (Ne) was estimated using SMC++. The genetic characteristics of PRS were analyzed by integrated haplotype score (iHS) and fixation index (FST). The result showed that r2 of PRS was 0.233 ± 0.280 in the range of 0–10 Kb and decreased with increasing distances. SMC++ tested that the Ne of PRS remained at 236.99 in recent generations. 184 genes were screened out under iHS 1% threshold, and 1148 genes were screened out with FST under the 5% threshold, and 29 genes were obtained from the intersection of the two gene sets. In this study, the genetic characteristics of PRS and QR were compared by ovine genome chip, and the related excellent genes were searched, providing reference for the protection of sheep germplasm resources and molecular breeding in a desert environment.
Impact of endogenous glucocorticoid on response to immune checkpoint blockade in patients with advanced cancer
Authors: Cui Yu , Han Xinyue , Liu Hongtao , Xie Qi , Guan Yaping , Yin Beibei , Xiao Junjuan , Feng Dongfeng , Wang Xuan , Li Junwei , Chen Jinghua , Liu Xiaolin , Li Xingyu , Nie Weiwei , Ma Lin , Liu Hairong , Liang Jing , Li Yan , Wang Baocheng , Wang Jun 
Published: April 2023

BackgroundPrevious studies indicate that exogenous use of glucocorticoid (GC) affects immune checkpoint inhibitor (ICI) efficacy. However, there is a paucity of clinical data evaluating the direct impact of endogenous GC on the efficacy for cancer patients with immune checkpoint blockade.MethodsWe first compared the endogenous circulating GC levels in healthy individuals and patients with cancer. We next retrospectively reviewed patients with advanced cancer with PD-1/PD-L1 inhibitor alone or combination therapy in a single center. The effects of baseline circulating GC levels on objective response rate (ORR), durable clinical benefit (DCB), progression‐free survival (PFS), and overall survival (OS) were analyzed. The association of the endogenous GC levels with circulating lymphocytes, cytokines levels, and neutrophil to lymphocyte ratio, and tumor infiltrating immune cells, were systematically analyzed.ResultsThe endogenous GC levels in advanced cancer patients were higher than those in early-stage cancer patients as well as healthy people. In the advanced cancer cohort with immune checkpoint blockade (n=130), patients with high baseline endogenous GC levels (n=80) had a significantly reduced ORR (10.0% vs 40.0%; p&lt;0.0001) and DCB (35.0% vs 73.5%, p=0.001) compared to those with low endogenous GC levels (n=50). The increased GC levels was significantly associated with reduced PFS (HR 2.023; p=0.0008) and OS (HR 2.809; p=0.0005). Moreover, statistically significant differences regarding PFS, and OS were also detected after propensity score matching. In a multivariable model, the endogenous GC was identified as an independent indicator for predicting PFS (HR 1.779; p=0.012) and OS (HR 2.468; p=0.013). High endogenous GC levels were significantly associated with reduced lymphocytes (p=0.019), increased neutrophil to lymphocyte ratio (p=0.0009), and increased interleukin-6 levels (p=0.025). Patients with high levels of endogenous GC had low numbers of tumor infiltrating CD3+ (p=0.001), CD8+ T (p=0.059), and CD4+ T (p=0.002) cells, and the numbers of circulating PD-1+ NK cells (p=0.012), and the ratio of CD8+PD-1+ to CD4+PD-1+ (p=0.031) were higher in patients with high levels of endogenous GC compared to low levels of endogenous GC.ConclusionBaseline endogenous GC increase executes a comprehensive negative effect on immunosurveillance and response to immunotherapy in real-world cancer patients accompanied with cancer progression.