bluuebunny/crossref_metadata_2025_split huggingface dataset:
Отношение тувинцев к земле в тувинской литературе XX–XXI вв.
Authors: Кужугет Шенне Юрьевна 
Published: March 2023

В статье анализируется тема отношения тувинцев к земле, которая менялась на протяжении XX–XXI вв. Источниками исследования выступили наиболее характерные произведения тувинской художественной литературы разных лет: романы классика тувинской литературы — Народного писателя Тувы М. Б. Кенин-Лопсана «Чылгычыныӊ өө» («Юрта табунщика») (1980), «Кырган-авай өпей ыры» («Колыбельная бабушки») (1984 г.), «Азаныӊ бичези кончуг» («Младший чертенок») (1989), «Алдын чүрек» («Золотое сердце») (1992), «Читкен уруг» («Исчезнувшая девушка») (2000), а также Народного писателя Тувы Н. Ш. Куулара «Муӊгаштатпаан муӊчулбас ыр» («Непрегражденная неунывающая песня») (2018).
Встречающиеся в произведениях аспекты, связанные с трактовками земли, которые имеют особенности в связи с определенными историческими событиями, процессами, делятся на три большие темы: связь с землей, тема потерянной земли и новое в представлениях о земле.
Этнограф и писатель М. Б. Кенин-Лопсан показывал представления тувинцев о том, что она священна, что ее надо знать, быть связанным и пр. Он поднимал и вопросы воспитания чувства любви к родным местам, и обязательств человека перед ними. События XX в. сделали для тувинцев остро актуальной тему потери родных земель, насильственного расставания с ней, разрывов связей, что также показывает Кенин-Лопсан.
Н. Ш. Куулар в своем романе показывает жизнь тувинцев уже начала XXI в. Он показал сразу несколько вопросов: тему забвения родных мест, массовой миграции в Кызыл, ностальгии по Туве в зарубежных поездках, земляческих объединениях студентов и приобретения тувинцами земли.
В работе в подтверждении приводятся цитаты из произведений на тувинском языке с авторскими переводами на русский язык.
Смысловые компоненты в представлениях о родине тувинской студенческой молодежи
Authors: Селиверстова Нина Анатольевна , Сорокин Олег Владимирович , Ооржак Сайлана Ужар-ооловна 
Published: March 2023

В статье на основе анализа представлений тувинской студенческой молодёжи о родине выявляются вариации её смыслов. Представления о родине студентов-тувинцев проанализированы на материалах фокус-групп (февраль — март 2022 г.). В рамках методологии целостного подхода студенты-тувинцы рассматриваются как часть тувинского общества, которые одновременно представляют социально-демографическую группу «российская молодёжь».
Анализ выявил смысловую структуру культурного пространства исследуемой группы. В культурном пространстве студентов-тувинцев бытуют традиционные, современные и гибридные смыслы родины, что сближает их с другими российскими студентами.
В традиционных смыслах студентов-тувинцев сохраняется связь между местом рождения, местом жительства предков, родителей и любовью к этому месту, положительными эмоциональными реакциями. В современных смыслах родины эта связь прерывается. Наблюдается секуляризация отношения к родине, имеющей в традиционной тувинской культуре сакральное значение. Данные смыслы отражают рационализацию сознания студентов-тувинцев, приоритет целей индивида, что является характерной чертой российской молодёжи в целом. Гибридные смыслы родины на индивидуально-групповом уровне демонстрируют запрос на сингулярность, уникальность самореализации. В них устанавливается связь между (1) правом на выбор места жительства и любовью к Туве, признанием Тувы своей родиной, (2) жизнью на земле предков и развитием родины; (3) называнием другой страны родиной предательством и допущением того, что и родина может предать, но и в этом случае она ею остаётся.
Результаты анализа являются содержательно-методическим основанием для количественного исследования отношения тувинской молодёжи к родине во взаимосвязи с гражданской и этнической идентичностями, представлениями о будущем и установками на миграцию.
Spinal cord epidural stimulation for motor and autonomic function recovery after chronic spinal cord injury: A case series and technical note
Authors: Boakye Maxwell , Ball Tyler , Dietz Nicholas , Sharma Mayur , Angeli Claudia , Rejc Enrico , Kirshblum Steven , Forrest Gail , Arnold Forest W. , Harkema Susan 
Published: March 2023

Background:
Traumatic spinal cord injury (tSCI) is a debilitating condition, leading to chronic morbidity and mortality. In recent peer-reviewed studies, spinal cord epidural stimulation (scES) enabled voluntary movement and return of over-ground walking in a small number of patients with motor complete SCI. Using the most extensive case series (n = 25) for chronic SCI, the present report describes our motor and cardiovascular and functional outcomes, surgical and training complication rates, quality of life (QOL) improvements, and patient satisfaction results after scES.

Methods:
This prospective study occurred at the University of Louisville from 2009 to 2020. scES interventions began 2–3 weeks after surgical implantation of the scES device. Perioperative complications were recorded as well as long-term complications during training and device related events. QOL outcomes and patient satisfaction were evaluated using the impairment domains model and a global patient satisfaction scale, respectively.

Results:
Twenty-five patients (80% male, mean age of 30.9 ± 9.4 years) with chronic motor complete tSCI underwent scES using an epidural paddle electrode and internal pulse generator. The interval from SCI to scES implantation was 5.9 ± 3.4 years. Two participants (8%) developed infections, and three additional patients required washouts (12%). All participants achieved voluntary movement after implantation. A total of 17 research participants (85%) reported that the procedure either met (n = 9) or exceeded (n = 8) their expectations, and 100% would undergo the operation again.

Conclusion:
scES in this series was safe and achieved numerous benefits on motor and cardiovascular regulation and improved patient-reported QOL in multiple domains, with a high degree of patient satisfaction. The multiple previously unreported benefits beyond improvements in motor function render scES a promising option for improving QOL after motor complete SCI. Further studies may quantify these other benefits and clarify scES’s role in SCI patients.
Anaerobik Gut Funguslarının Uzun Süreli Muhafazalarında Agarlı Besi Yerlerinin ve Ön Soğutma İşleminin Etkinliğinin Araştırılması
Authors: TURGUT Tuğçe , TANIŞ Ayşe Nur , ÖZKÖSE Emin , EKİNCİ Mehmet Sait 
Published: March 2023

Amaç: Anaerobik gut funguslarının (AGF) kültüre alınması ve uzun süreli muhafazası özellikle aerobik mikroorganizmalar ve prokaryotik gut mikrobiyom ile karşılaştırıldıklarında göreceli olarak düşük verimlidir. Anaerobik koşullar altında yapılan bu muhafaza işleminde hücre yapılarının düşük sıcaklıklarda uzun süreli korunması amacıyla gliserol, dimetil sülfoksit (DMSO), kan serumu, polivinilpirolidon (PVP) ve sorbitol gibi kriyoprotektanlar kullanılır.
Materyal ve Metot: Bu çalışmada farklı enerji kaynakları (buğday samanı, sükroz, dekstroz, ksiloz ve glikoz) kullanılarak dağ keçisi dışkısından izolasyonu ve saflaştırılması yapılan Caecomyces GMLF77 izolatı ile kültür koleksiyonundan temin edilen Orpinomyces GMLF18 izolatı 6 aylık süreyle eğik agar ve Roll tüp agar besi yerlerinde farklı sıcaklık kombinasyonlarında muhafaza edilmiş ve izolatların yaşama oranları analiz edilmiştir.
Bulgular: Caecomyces GMLF77 izolatı en yüksek yaşama oranını (%67) ksiloz içeren eğik agar içerisinde %15 gliserol varlığında doğrudan –196 °C’de (sıvı azot) muhafazaya alındığında göstermiştir. Orpinomyces GMLF18 ise glikoz içeren eğik agarlı besi yerinde, 6 aylık süreyle ön soğutmasız –196 °C’de muhafazasında %83 yaşama oranı göstermiştir. Diğer taraftan her iki izolat da kullanılan tüm besi yeri ve enerji kaynaklarında 4 °C’de ön soğutmaya tabi tutulduklarında yaşama şansı bulamamışlardır.
Sonuç: Sonuçlar fungal izolatların sıvı azota aktarılmadan önce ön soğutma işlemine tabi tutulmalarının uzun süreli yaşama oranlarının artırılmasına önemli bir katkı sağlamadığını ortaya koymuştur.
Safety of vagus nerve stimulation and responsive neurostimulation used in combination for multifocal and generalized onset epilepsy in pediatric patients
Authors: Beaudreault Cameron P. , Spirollari Eris , Naftchi Alexandria F. , Sukul Vishad , Das Ankita , Vazquez Sima , Wolf Steven M. , McGoldrick Patricia E. , Muh Carrie R. 
Published: March 2023

OBJECTIVE
The aim of this study was to assess the safety and efficacy of combined active responsive neurostimulation (RNS) and vagus nerve stimulation (VNS) therapies in pediatric patients with drug-resistant epilepsy.

METHODS
A single-center retrospective chart review was conducted on pediatric patients implanted with the RNS System with a concomitant active VNS System (VNS+RNS) between 2015 and 2021. Patients with at least 1 month of overlapping concomitant VNS and RNS treatment were included. Patients who had an RNS device implanted after 21 years of age, those who had responsive neurostimulators implanted after their VNS was inactivated, or those in whom the VNS battery died and was not replaced before RNS System implantation were excluded.

RESULTS
Seven pediatric VNS+RNS patients were identified, and their courses of treatment were evaluated. All patients tolerated concurrent VNS and RNS treatment well, no device-device interactions were identified, and no major treatment-related adverse effects were noted. The median follow-up after RNS System implantation was 1.2 years. By electroclinical criteria, all 7 patients achieved 75%–99% reductions in the frequency of disabling seizures after RNS System implantation. By patient and caregiver report, 2 patients (28.6%) had 75%–99% reductions in the frequency of their disabling seizures, 2 patients (28.6%) achieved 50%–74% reductions, 2 patients achieved 1%–24% reduction in frequency of disabling seizures, and 1 patient (14.3%) experienced a 1%–24% increase in seizure frequency. The available VNS magnet swipe data identified 2 patients with 75%–99% reductions in seizure frequency as measured by magnet swipes, one with 25%–49% reductions and the other with 1%–24% increases in seizure frequency as measured by magnet swipes.

CONCLUSIONS
This study demonstrated that RNS and VNS therapies can safely be used simultaneously in pediatric patients. RNS may potentially augment the therapeutic effects of VNS treatment. Patients in whom a response to VNS has been suboptimal should still be considered for RNS therapy.
Analysis of recovery trajectories in degenerative cervical myelopathy to facilitate improved patient counseling and individualized treatment recommendations
Authors: Jaja Blessing N. R. , Witiw Christopher D. , Harrington Erin M. , He Yingshi , Moghaddamjou Ali , Fehlings Michael G. , Wilson Jefferson R. 
Published: March 2023

OBJECTIVE
There is a need to better understand and predict postsurgical outcomes for degenerative cervical myelopathy (DCM) patients, particularly to support treatment decisions for patients with mild DCM. The goal of this study was to identify and predict outcome trajectories for DCM patients up to 2 years postsurgery.

METHODS
The authors analyzed two North American multicenter prospective DCM studies (n = 757). Functional recovery and physical health component quality of life were assessed in DCM patients at baseline, 6 months, and 1 and 2 years postoperatively using the modified Japanese Orthopaedic Association (mJOA) score and Physical Component Summary (PCS) of the SF-36, respectively. Group-based trajectory modeling was used to identify recovery trajectories for mild, moderate, and severe DCM. Prediction models for recovery trajectories were developed and validated in bootstrap resamples.

RESULTS
Two recovery trajectories were identified for the functional and physical components of quality of life: good recovery and marginal recovery. Depending on outcome and myelopathy severity, one-half to three-fourths of the study patients followed the good recovery trajectory characterized by improvement in mJOA and PCS scores over time. The remaining one-half to one-fourth of patients followed the marginal recovery trajectory, experiencing little improvement and, in certain cases, worsening postoperatively. The prediction model for mild DCM had an area under the curve of 0.72 (95% CI 0.65–0.80), with preoperative neck pain, smoking, and posterior surgical approach noted as dominant predictors of marginal recovery.

CONCLUSIONS
Surgically treated DCM patients follow distinct recovery trajectories in the first 2 years postoperatively. While most patients experience substantial improvement, a significant minority experience little improvement or worsening. The ability to predict DCM patient recovery trajectories in the preoperative setting facilitates the formulation of individualized treatment recommendations for patients with mild symptoms.
Hypotension requiring vasopressor treatment and increased cardiac complications in elderly spinal cord injury patients: a prospective TRACK-SCI registry study
Authors: Agarwal Nitin , Blitstein Jacob , Lui Austin , Torres-Espin Abel , Vasnarungruengkul Chalisar , Burke John , Mummaneni Praveen V. , Dhall Sanjay S. , Weinstein Philip R. , Duong-Fernandez Xuan , Chou Austin , Pan Jonathan , Singh Vineeta , Ferguson Adam R. , Hemmerle Debra D. , Kyritsis Nikos , Talbott Jason F. , Whetstone William D. , Bresnahan Jacqueline C. , Beattie Michael S. , Manley Geoffrey T. , DiGiorgio Anthony 
Published: March 2023

OBJECTIVE
Increasing life expectancy has led to an older population. In this study, the authors analyzed complications and outcomes in elderly patients following spinal cord injury (SCI) using the established multi-institutional prospective study Transforming Research and Clinical Knowledge in SCI (TRACK-SCI) database collected in the Department of Neurosurgical Surgery at the University of California, San Francisco.

METHODS
TRACK-SCI was queried for elderly individuals (≥ 65 years of age) with traumatic SCI from 2015 to 2019. Primary outcomes of interest included total hospital length of stay, perioperative complications, postoperative complications, and in-hospital mortality. Secondary outcomes included disposition location, and neurological improvement based on the American Spinal Injury Association Impairment Scale (AIS) grade at discharge. Descriptive analysis, Fisher’s exact test, univariate analysis, and multivariable regression analysis were performed.

RESULTS
The study cohort consisted of 40 elderly patients. The in-hospital mortality rate was 10%. Every patient in this cohort experienced at least 1 complication, with a mean of 6.6 separate complications (median 6, mode 4). The most common complication categories were cardiovascular, with a mean of 1.6 complications (median 1, mode 1), and pulmonary, with a mean of 1.3 (median 1, mode 0) complications, with 35 patients (87.5%) having at least 1 cardiovascular complication and 25 (62.5%) having at least 1 pulmonary complication. Overall, 32 patients (80%) required vasopressor treatment for mean arterial pressure (MAP) maintenance goals. The use of norepinephrine correlated with increased cardiovascular complications. Only 3 patients (7.5%) of the total cohort had an improved AIS grade compared with their acute level at admission.

CONCLUSIONS
Given the increased frequency of cardiovascular complications associated with vasopressor use in elderly SCI patients, caution is warranted when targeting MAP goals in these patients. A downward adjustment of blood pressure maintenance goals and prophylactic cardiology consultation to select the most appropriate vasopressor agent may be advisable for SCI patients ≥ 65 years of age.
Chlorine Dioxide Reprograms Rhizosphere Microbial Communities to Enrich Interactions with Tobacco (Nicotiana tabacum)
Authors: QI SHI , ZHANG JILI , LUAN XINBO , LI JUNLIN , HE ZIKANG , LONG JUNRU , XU MENGYUN , LI PING , CHEN ZEPENG , WEI JIANYU , YAN JIAN 
Published: March 2023

Abstract
For decades chlorine dioxide has been used in water disinfection with excellent results. As the scope of application expands, chlorine dioxide has the potential for soil disinfection. We used amplicon sequencing and gas chromatography-mass spectrometry to compare the changes of four mixed rhizosphere microbial community samples and 12 tobacco leaf volatile samples four months after the flood irrigation with chlorine dioxide in different concentrations (0, 2, 4, 8 mg/l). Phenotypic data of 60 tobacco plants were also collected. The effects of chlorine dioxide on rhizosphere microorganisms were positively correlated with dose gradients. Bacteria responded more strongly in both community structure and metabolic pathways than fungi. Five new bacterial phyla (Firmicutes, Bacteroidota, Myxococcota, Patescibacteria, Verrucomicroboata) appeared in chlorine dioxide treatment groups, while the fungal community only appeared as one new fungal phylum (Basidomycota). Alterations in 271 predicted metabolic bacterial pathways were found. However, in the fungal community were only 10 alternations. The correlations between leaf volatile compounds and rhizosphere microorganisms under the influence of chlorine dioxide treatment could be observed based on network results. However, natural connectivity had already been declining rapidly when less than 20% of the network’s nodes were removed. Therefore, the microbe-metabolite network is not stable. It might be why chlorine dioxide treatments did not significantly affect tobacco quality (p = 0.754) and phenotype (p = 0.867). As a comprehensive investigation of chlorine dioxide in agriculture, this study proves the effectiveness and safety of chlorine dioxide soil disinfection and widens the application range of chlorine dioxide.
Effects of exogenous retinoic acid on ocular parameters in Guinea pigs with form deprivation myopia
Authors: Wu Yajun , Feng Yuliang , Yang Jiasong , Fan Hua , Yu Zitong , Xie Xiaolin , Dai Yumeng , Huang Xin , Li Wensheng 
Published: March 2023

Aim: Myopia is a common chronic eye disease, this study is to investigate the effects of exogenous retinoic acid (RA) on intraocular parameters, especially choroidal thickness (CT) and retinal thickness (RT), in guinea pigs with form deprivation myopia (FDM).Methods: A total of 80 male guinea pigs were divided randomly into 4 groups: Control, FDM, FDM + RA, and FDM + Citral groups. The FDM + RA group was given 24 mg/kg RA dissolved in 0.4 mL peanut oil; the FDM + Citral group was given citral 445 mg/kg dissolved in 0.4 mL peanut oil; The other two groups were given 0.4 mL peanut oil. After 4 weeks, the refractive error (RE), axial length (AL), and intraocular pressure (IOP) of all guinea pigs were measured, and the parameters of RT and CT were obtained using enhanced depth imaging optical coherence tomography (EDI-OCT).Results: After 4 weeks, both the RE and AL in the FDM and FDM + RA groups were increased, and the RT and CT in both groups were smaller than those in the Control group (p &lt; 0.05). Only the IOP of the right eye in the FDM + RA group increased significantly (p &lt; 0.05). The RT of the right eye of the 4 groups was compared: Control group &gt; FDM + Citral group &gt; FDM group &gt; FDM + RA group. Compared with the RT of the left eye and the right eye among the 4 groups, the RT of the right eye in the FDM and FDM + RA groups was significantly less than that in the left eye (p &lt; 0.05). Moreover, the CT of the right eye in the Control group was greater than that in the other three groups (p &lt; 0.0001). There was no significant difference in the CT among the FDM, FDM + RA, and FDM + Citral groups (p &gt; 0.05). In contrast to the RT results, the CT results of the left and right eyes in the FDM + Citral group showed statistically significant differences (p &lt; 0.05).Conclusion: RA participates in the progression of FDM as a regulatory factor. Exogenous RA can increase the RE, AL, and IOP of FDM guinea pigs, and might aggravate the retinal thinning of FDM guinea pigs. Citral can inhibit these changes, but RA might not affect the thickness of the choroid.
Functional liposome loaded curcumin for the treatment of Streptococcus mutans biofilm
Authors: Hu Zhimin , Tang Ying , Jiang Bulin , Xu Yue , Liu Siying , Huang Cui 
Published: March 2023

Introduction: Plaque biofilms, mainly formed by Streptococcus mutans (S. mutans), play an important role in the occurrence and development of dental caries. Antibiotic treatment is the traditional way to control plaque. However, problems such as poor drug penetration and antibiotic resistance have encouraged the search for alternative strategies. In this paper, we hope to avoid antibiotic resistance through the antibacterial effect of curcumin, a natural plant extract with photodynamic effects, on S. mutans. However, the clinical application of curcumin is limited due to its low water solubility, poor stability, high metabolic rate, fast clearance rate, and limited bioavailability. In recent years, liposomes have become a widely used drug carrier due to their numerous advantages, such as high drug loading efficiency, high stability in the biological environment, controlled release, biocompatibility, non-toxic, and biodegradability. So, we constructed a curcumin-loaded liposome (Cur@LP) to avoid the defect of curcumin.Methods: Cur@LP functioned with NHS can adhere to the surface of the S. mutans biofilm by condensation reaction. Liposome (LP) and Cur@LP was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The cytotoxicity of Cur@LP was evaluated by CCK-8 assay and LDH assay. The adhesion of Cur@LP to S. mutans biofilm was observed by confocal laser scanning microscope (CLSM). The antibiofilm efficiency of Cur@LP were evaluated by crystal violet staining, CLSM, and scanning electron microscope (SEM).Results: The mean diameter of LP and Cur@LP were 206.67 ± 8.38 nm and 312 ± 18.78 nm respectively. The ζ-potential of LP and Cur@LP were ∼−19.3 mV and ∼−20.8 mV respectively. The encapsulation efficiency of Cur@LP was (42.61 ± 2.19) %, and curcumin was rapidly released up to ±21% at 2 h. Cur@LP has negligible cytotoxicity, and can effectively adhered to the S. mutans biofilm and inhibited its growth.Discussion: Curcumin has been widely studied in many fields such as cancer, which can be attributed to its antioxidant and anti-inflammatory effects. At present, there are few studies on the delivery of curcumin to S. mutans biofilm. In this study, we verified the adhesion and antibiofilm of Cur@LP to S. mutans biofilm. This biofilm removal strategy has the potential to be translated into the clinic.