bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Individual Tree Crown Detection and Delineation with Convolutional Neural Networks (CNN)
Authors: Zhao Haotian , Morgenroth Justin , Pearse Grant , Schindler Jan 
Published: April 2023

Abstract

Purpose of Review
Crown detection and measurement at the individual tree level provide detailed information for accurate forest management. To efficiently acquire such information, approaches to conduct individual tree detection and crown delineation (ITDCD) using remotely sensed data have been proposed. In recent years, deep learning, specifically convolutional neural networks (CNN), has shown potential in this field. This article provides a systematic review of the studies that used CNN for ITDCD and identifies major trends and research gaps across six perspectives: accuracy assessment methods, data types, platforms and resolutions, forest environments, CNN models, and training strategies and techniques.

Recent Findings
CNN models were mostly applied to high-resolution red–green–blue (RGB) images. When compared with other state-of-the-art approaches, CNN models showed significant improvements in accuracy. One study reported an increase in detection accuracy of over 11%, while two studies reported increases in F1-score of over 16%. However, model performance varied across different forest environments and data types. Several factors including data scarcity, model selection, and training approaches affected ITDCD results.

Summary
Future studies could (1) explore data fusion approaches to take advantage of the characteristics of different types of remote sensing data, (2) further improve data efficiency with customised sample approaches and synthetic samples, (3) explore the potential of smaller CNN models and compare their learning efficiency with commonly used models, and (4) evaluate impacts of pre-training and parameter tunings.
Hospital antibiotic consumption—an interrupted time series analysis of the early and late phases of the COVID-19 pandemic in Poland, a retrospective study
Authors: Siewierska Małgorzata , Gajda Mateusz , Opalska Aleksandra , Brudło Michał , Krzyściak Paweł , Gryglewska Barbara , Różańska Anna , Wójkowska-Mach Jadwiga 
Published: April 2023

Abstract
Background
COVID-19 has been challenging for the entire healthcare system, due to the lack of sufficient treatment protocols, especially during initial phases and as regards antibiotic use. The aim of this study was to identify the trends of antimicrobial consumption in one of the largest tertiary hospitals in Poland during COVID-19.

Methods
This is a retrospective study conducted at the University Hospital in Krakow, Poland, between Feb/Mar 2020 and Feb 2021. It included 250 patients. All included patients were hospitalized due to COVID-19 with confirmed SARS-CoV-2 infection without bacterial co-infections during the first phase of COVID-19 in Europe and following 3-month intervals: five equal groups of patients in each. COVID severity and antibiotic consumption were assessed according to WHO recommendations.

Results
In total 178 (71.2%) patients received antibiotics with a incidence rate of laboratory-confirmed healthcare-associated infection (LC-HAI) was 20%. The severity of COVID-19 was mild in 40.8%, moderate in 36.8%, and severe in 22.4% cases. The ABX administration was significantly higher for intensive care unit (ICU) patients (97.7% vs. 65.7%). Length of hospital stay was extended for patients with ABX (22.3 vs. 14.4 days). In total, 3 946.87 DDDs of ABXs were used, including 1512.63 DDDs in ICU, accounting for 780.94 and 2522.73 per 1000 hospital days, respectively. The median values of antibiotic DDD were greater among patients with severe COVID-19 than others (20.92). Patients admitted at the beginning of the pandemic (Feb/Mar, May 2020) had significantly greater values of median DDDs, respectively, 25.3 and 16.0 compared to those admitted in later (Aug, Nov 2020; Feb 2021), respectively, 11.0, 11.0 and 11.2, but the proportion of patients receiving ABX therapy was lower in Feb/Mar and May 2020 (62.0 and 48.0%), whereas the highest during the late period of the pandemic, i.e., in Aug, Nov. 2020 and Feb. 2021 (78% and both 84.0%).

Conclusions
Data suggest great misuse of antibiotics without relevant data about HAIs. Almost all ICU patients received some antibiotics, which was correlated with prolonged hospitalization.
The Southern-sky MWA Rapid Two-metre (SMART) pulsar survey—I. Survey design and processing pipeline
Authors: Bhat N. D. R. , Swainston N. A. , McSweeney S. J. , Xue M. , Meyers B.W. , Kudale S. , Dai S. , Tremblay S. E. , van Straten W. , Shannon R. M. , Smith K. R. , Sokolowski M. , Ord S. M. , Sleap G. , Williams A. , Hancock P. J. , Lange R. , Tocknell J. , Johnston-Hollitt M. , Kaplan D. L. , Tingay S. J. , Walker M. 
Published: April 2023

AbstractWe present an overview of the Southern-sky MWA Rapid Two-metre (SMART) pulsar survey that exploits the Murchison Widefield Array’s large field of view and voltage-capture system to survey the sky south of 30$^{\circ}$in declination for pulsars and fast transients in the 140–170 MHz band. The survey is enabled by the advent of the Phase II MWA’s compact configuration, which offers an enormous efficiency in beam-forming and processing costs, thereby making an all-sky survey of this magnitude tractable with the MWA. Even with the long dwell times employed for the survey (4800 s), data collection can be completed in$<$100 h of telescope time, while still retaining the ability to reach a limiting sensitivity of$\sim$2–3 mJy (at 150 MHz, near zenith), which is effectively 3–5 times deeper than the previous-generation low-frequency southern-sky pulsar survey, completed in the 1990s. Each observation is processed to generate$\sim$5000–8000 tied-array beams that tessellate the full$\sim 610\, {\textrm{deg}^{2}}$field of view (at 155 MHz), which are then processed to search for pulsars. The voltage-capture recording of the survey also allows a multitude ofpost hocprocessing options including the reprocessing of data for higher time resolution and even exploring image-based techniques for pulsar candidate identification. Due to the substantial computational cost in pulsar searches at low frequencies, the survey data processing is undertaken in multiple passes: in the first pass, a shallow survey is performed, where 10 min of each observation is processed, reaching about one-third of the full-search sensitivity. Here we present the system overview including details of ongoing processing and initial results. Further details including first pulsar discoveries and a census of low-frequency detections are presented in a companion paper. Future plans include deeper searches to reach the full sensitivity and acceleration searches to target binary and millisecond pulsars. Our simulation analysis forecasts$\sim$300 new pulsars upon the completion of full processing. The SMART survey will also generate a complete digital record of the low-frequency sky, which will serve as a valuable reference for future pulsar searches planned with the low-frequency Square Kilometre Array.
Antiviral treatment in schizophrenia: a randomized pilot PET study on the effects of valaciclovir on neuroinflammation
Authors: Jonker Iris , Doorduin Janine , Knegtering Henderikus , van't Hag Erna , Dierckx Rudi A. , de Vries Erik F. J. , Schoevers Robert A. , Klein Hans C. 
Published: April 2023

AbstractBackgroundPatients with schizophrenia experience cognitive impairment, which could be related to neuroinflammation in the hippocampus. The cause for such hippocampal inflammation is still unknown, but it has been suggested that herpes virus infection is involved. This study therefore aimed to determine whether add-on treatment of schizophrenic patients with the anti- viral drug valaciclovir would reduce hippocampal neuroinflammation and consequently improve cognitive symptoms.MethodsWe performed a double-blind monocenter study in 24 male and female patients with schizophrenia, experiencing active psychotic symptoms. Patients were orally treated with the anti-viral drug valaciclovir for seven consecutive days (8 g/day). Neuroinflammation was measured with Positron Emission Tomography using the translocator protein ligand [11C]-PK11195, pre-treatment and at seven days post-treatment, as were psychotic symptoms and cognition.ResultsValaciclovir treatment resulted in reduced TSPO binding (39%) in the hippocampus, as well as in the brainstem, frontal lobe, temporal lobe, parahippocampal gyrus, amygdala, parietal lobe, occipital lobe, insula and cingulate gyri, nucleus accumbens and thalamus (31–40%) when using binding potential (BPND) as an outcome. With total distribution volume (VT) as outcome we found essentially the same results, but associations only approached statistical significance (p = 0.050 for hippocampus). Placebo treatment did not affect neuroinflammation. No effects of valaciclovir on psychotic symptoms or cognitive functioning were found.ConclusionWe found a decreased TSPO binding following antiviral treatment, which could suggest a viral underpinning of neuroinflammation in psychotic patients. Whether this reduced neuroinflammation by treatment with valaciclovir has clinical implications and is specific for schizophrenia warrants further research.
Efficacy of dynamic interpersonal therapy for major depressive disorder in China: results of a multicentered, three-arm, randomized, controlled trial
Authors: Wang Yuan , Yao Jiayu , Koszycki Diana , Jiang Wenhui , Fang Fang , Wang Minghong , Tao Jing , Zhao Wenqing , Liu Yilan , Su Shanshan , Peng Yihua , Wang Hongyan , Wang Lanlan , Gao Rui , Gu Junjie , Zhang Jie , Bai Yanle , Wu Yanru , Su Yousong , Zhao Yating , Zheng Ziwei , Chen Shuangyi , Qiu Jianyin 
Published: April 2023

AbstractBackgroundDynamic interpersonal therapy (DIT) is a brief, structured psychodynamic psychotherapy with demonstrated efficacy in treating major depressive disorder (MDD). The aim of the study was to determine whether DIT is an acceptable and efficacious treatment for MDD patients in China.MethodPatients were randomized to 16-week treatments with either DIT plus antidepressant medication (DIT + ADM; n = 66), general supportive therapy plus antidepressant medication (GST + ADM; n = 75) or antidepressant medication alone (ADM; n = 70). The Hamilton Depression Rating Scale (HAMD) administered by blind raters was the primary efficacy measure. Assessments were completed during the acute 16-week treatment and up to 12-month posttreatment.ResultsThe group × time interaction was significant for the primary outcome HAMD (F = 2.900, df1 = 10, df2 = 774.72, p = 0.001) in the acute treatment phase. Pairwise comparisons showed a benefit of DIT + ADM over ADM at weeks 12 [least-squares (LS) mean difference = −3.161, p = 0.007] and 16 (LS mean difference = −3.237, p = 0.004). Because of the unexpected high attrition during the posttreatment follow-up phase, analyses of follow-up data were considered exploratory. Differences between DIT + ADM and ADM remained significant at the 1-, 6-, and 12-month follow-up (ps range from 0.001 to 0.027). DIT + ADM had no advantage over GST + ADM during the acute treatment phase. However, at the 12-month follow-up, patients who received DIT remained less depressed.ConclusionsAcute treatment with DIT or GST in combination with ADM was similarly efficacious in reducing depressive symptoms and yielded a better outcome than ADM alone. DIT may provide MDD patients with long-term benefits in symptom improvement but results must be viewed with caution.
Paucity problems and some relatives of Vinogradov’s mean value theorem
Authors: WOOLEY TREVOR D. 
Published: April 2023

AbstractWhen$k\geqslant 4$and$0\leqslant d\leqslant (k-2)/4$, we consider the system of Diophantine equations\begin{align*}x_1^j+\ldots +x_k^j=y_1^j+\ldots +y_k^j\quad (1\leqslant j\leqslant k,\, j\ne k-d).\end{align*}We show that in this cousin of a Vinogradov system, there is a paucity of non-diagonal positive integral solutions. Our quantitative estimates are particularly sharp when$d=o\!\left(k^{1/4}\right)$.
A broadband Butler-based dual-polarized omni-directional antenna
Authors: Wu Xiaoqing , Shen Lin-Ping , Zhang Lijun 
Published: April 2023

AbstractThis paper presents a broadband Butler-based slant ±45° dual-polarized omni-directional antenna working at the frequency band of 1.69–2.69 GHz for extending wireless communication network capacity in the limited service size. The proposed antenna realizes a 360° full coverage with wider bandwidth in a compact cylinder and increases the network capacity to 6 × 6 MIMO instead of using three traditional 2 × 2 MIMO omni-directional antennas. Theoretical analysis, simulation, and fabrication are conducted to validate the idea of the proposed omni-directional antenna. The measured results show 46% bandwidth with 15 dB return loss, 2.2 dB azimuth null and 8.9–10.5 dBi gain for port-C with 0° phase increment, and 14.1 dB azimuth null and 9.6–10.6 dBi gain for port-L/R (left/right) with ±120° phase increment, respectively.
Compact modified hourglass-shaped aperture-coupled antenna for radar applications
Authors: Priyalatha P. , Kumari Runa , Nandi Sourav 
Published: April 2023

AbstractThis paper furnishes a compact modified hourglass-shaped aperture-coupled antenna for radar applications. The effect of slots of various shapes and various slot lengths on the input impedance, radiation pattern, and gain of the antenna are analyzed. The proposed antenna, designed using a modified hourglass-shaped aperture, offers a gain of 8.214 dBi for an compact antenna with a dimension of 20.4 × 20.4 × 1.041 mm3 and an aperture area of 2.495 mm2. Implementation of this proposed modified hourglass-shaped aperture offers a high gain per unit radiating patch area of 40.26 dB/$\lambda _g ^2$ and a high gain per unit aperture area of 1324.84 dB/$\lambda _g ^2$. The proposed aperture feeds a circular patch which radiates at its resonant frequency of 10.5 GHz. The proposed design is fabricated and the simulated results are verified experimentally. Equivalent circuit analysis is also done. A measured gain of 7.2 dBi is observed at 10.5 GHz. The physical area of the antenna is reduced without compromising the gain by judiciously choosing the shape of slot with more degree of freedom for impedance matching. The proposed antenna is well suited for the unit cell of phased array antennas for X-band missile radar applications.
Assessment of Top of Atmosphere, Atmospheric and Surface Energy Budgets in CMIP6 Models on Regional Scales
Authors: Li Donghao , Folini Doris , Wild Martin 
Published: April 2023

AbstractWe examine top of atmosphere (TOA), atmospheric, and surface energy budget components of 53 CMIP6 models for the period 2000–2009 on regional scales with respect to two reference data sets: the NASA Energy and Water cycle Study (NEWS), from which we adopt the regional decomposition, and the Clouds and the Earth's Radiant Energy System (CERES) Energy Balanced and Filled (EBAF). Focusing on regional scale, CMIP6 models tend to have more energy entering or less energy leaving the climate systems at TOA over the Northern Hemisphere land, Southern Hemisphere ocean and the polar regions compared to CERES EBAF, while the contrary applies in other regions. Atmospheric net shortwave and longwave fluxes both tend to be underestimated in CMIP6 models as compared to EBAF, with substantial regional differences. Regional surface radiative fluxes as reported by NEWS and EBAF can differ substantially. Nevertheless, robust regional biases exist in CMIP6. Surface upward shortwave radiation is overestimated by 43 (81%) models over Eurasia. For almost all surface radiative flux components over the North Atlantic and Indian Ocean, there are at least 21 (40%) models which fall outside the NEWS uncertainty range. Latent heat flux is overestimated over most of the land and ocean regions while firm conclusions for sensible heat flux remain elusive due to discrepancies between different reference data sets. Compared to CMIP5, there is an overall improvement in CMIP6 on regional scale. Still, substantial deficiencies and spreads on regional scale remain, which are potentially translated into an inadequate simulation of atmospheric dynamics or hydrological cycle.
Record‐Strong Eastward Propagating 4‐Day Wave in the Southern Hemisphere Observed During the 2019 Antarctic Sudden Stratospheric Warming
Authors: Luo Jiahui , Ma Zheng , Gong Yun , Zhang Shaodong , Xiao Qiao , Huang Chunming , Huang Kaiming 
Published: April 2023

AbstractBased on the zonal winds from the Modern‐Era Retrospective Analysis for Research and Applications, version 2 reanalysis data, we investigate the enhancement of an eastward propagating 4‐day wave (E4DW) during the 2019 Antarctic sudden stratospheric warming (SSW). The amplitudes of E4DW are centered at 50°S and 50 km with a maximum amplitude of ∼20 m/s. The enhanced E4DW significantly exceeds the climatological level and has the strongest amplitude in the Southern Hemisphere since 1980. Our results show that the E4DW is generated by the atmospheric instabilities via a double‐jet configuration of the zonal mean zonal winds. Our analysis further indicates that the special structure of the zonal mean zonal winds caused by the 2019 Antarctic SSW at the stratopause is responsible for the excitation of the record‐strong E4DW in 2019 in the Southern Hemisphere.
Characterizing the Variability of Boundary Currents and Ocean Heat Content Around New Zealand Using a Multi‐Decadal High‐Resolution Regional Ocean Model
Authors: Kerry Colette , Roughan Moninya , De Souza Joao 
Published: April 2023

AbstractNew Zealand is located in the southwest Pacific Ocean and is surrounded by a complex system of boundary currents that vary on a variety of time scales, with important impacts on weather, primary productivity, and fisheries. While various observational and modeling studies have shed light on many of the characteristics of New Zealand's ocean circulation, this study provides a comprehensive, quantitative, seamless, 3‐dimensional characterization of the region's boundary current circulation and ocean heat content. We use a 28 yr long hydrodynamic model simulation that accurately represents the mean and variability of the ocean circulation to characterize and quantify the temporal and spatial variability across the region. We show that low‐frequency variability in boundary current transport and upper ocean heat content are correlated over the entire New Zealand oceanic region. Oceanic eddies dominate heat content variability at intra‐annual scales in the northeast of the region, while on the west and southeast coasts heat content varies predominantly at interannual scales controlled by large‐scale changes in the subtropical and sub‐Antarctic fronts. The model shows a significant downstream strengthening and deepening of the boundary currents off northeast New Zealand which, if confirmed by observations, could suggest a significant new understanding of this Western Boundary Current system. This study presents a region‐wide characterization of the temporal and spatial variability of ocean currents and heat content, and their interconnections, providing a vital basis for understanding climate change impacts and the increasing occurrence of marine heatwaves.
Using naltrexone to validate a human laboratory test system to screen new medications for alcoholism (TESMA)- a randomized clinical trial
Authors: Spreer Maik , Grählert Xina , Klut Ina-Maria , Al Hamdan Feras , Sommer Wolfgang H. , Plawecki Martin H. , O’Connor Sean , Böttcher Michael , Sauer Cathrin , Smolka Michael N. , Zimmermann Ulrich S. 
Published: April 2023

AbstractThis registered clinical trial sought to validate a laboratory test system devised to screen medications for alcoholism treatment (TESMA) under different contingencies of alcohol reinforcement. Forty-six nondependent, but at least medium-risk drinkers were given the opportunity to earn intravenous infusions of ethanol, or saline, as rewards for work in a progressive-ratio paradigm. Work demand pattern and alcohol exposure dynamics were devised to achieve a gradual shift from low-demand work for alcohol (WFA) permitting quickly increasing breath alcohol concentrations (BrAC) to high-demand WFA, which could only decelerate an inevitable decrease of the previously earned BrAC. Thereby, the reward contingency changed, modeling different drinking motivations. The experiment was repeated after at least 7 days of randomized, double-blinded treatment with naltrexone, escalated to 50 mg/d, or placebo. Subjects treated with naltrexone reduced their cumulative WFA (cWFA) slightly more than participants receiving placebo. This difference was not statistically significant in the preplanned analysis of the entire 150 min of self-administration, i.e., our primary endpoint (p = 0.471, Cohen’s d = 0.215). Naltrexone serum levels correlated with change in cWFA (r = −0.53; p = 0.014). Separate exploratory analyses revealed that naltrexone significantly reduced WFA during the first, but not the second half of the experiment (Cohen’s d = 0.643 and 0.14, respectively). Phase-dependent associations of WFA with changes in subjective stimulation, wellbeing and desire for alcohol suggested that the predominant reinforcement of WFA was positive during the first phase only, and might have been negative during the second. We conclude that the TESMA is a safe and practical method. It bears the potential to quickly and efficiently screen new drugs for their efficacy to attenuate positively reinforced alcohol consumption. It possibly also provides a condition of negative reinforcement, and for the first time provides experimental evidence suggesting that naltrexone’s effect might depend on reward contingency.
GPR84 regulates pulmonary inflammation by modulating neutrophil functions
Authors: Wang Si-wei , Zhang Qing , Lu Dan , Fang You-chen , Yan Xiao-ci , Chen Jing , Xia Zhi-kan , Yuan Qian-ting , Chen Lin-hai , Zhang Yang-ming , Nan Fa-jun , Xie Xin 
Published: April 2023

AbstractAcute lung injury (ALI) is an acute, progressive hypoxic respiratory failure that could develop into acute respiratory distress syndrome (ARDS) with very high mortality rate. ALI is believed to be caused by uncontrolled inflammation, and multiple types of immune cells, especially neutrophils, are critically involved in the development of ALI. The treatment for ALI/ARDS is very limited, a better understanding of the pathogenesis and new therapies are urgently needed. Here we discover that GPR84, a medium chain fatty acid receptor, plays critical roles in ALI development by regulating neutrophil functions. GPR84 is highly upregulated in the cells isolated from the bronchoalveolar lavage fluid of LPS-induced ALI mice. GPR84 deficiency or blockage significantly ameliorated ALI mice lung inflammation by reducing neutrophils infiltration and oxidative stress. Further studies reveal that activation of GPR84 strongly induced reactive oxygen species production from neutrophils by stimulating Lyn, AKT and ERK1/2 activation and the assembly of the NADPH oxidase. These results reveal an important role of GPR84 in neutrophil functions and lung inflammation and strongly suggest that GPR84 is a potential drug target for ALI.