bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological expressions of early life trauma in the immune system of older adults
Authors: Noppert Grace A. , Duchowny Kate A. , Stebbins Rebecca , Aiello Allison E. , Dowd Jennifer B. , Clarke Philippa 
Published: June 2023

Background
Poor immune function is associated with increased risk for a number of age-related diseases, however, little is known about the impact of early life trauma on immune function in late-life.

Methods
Using nationally representative data from the Health and Retirement Study (n = 5,823), we examined the association between experiencing parental/caregiver death or separation before age 16 and four indicators of immune function in late-life: C-reactive Protein (CRP), Interleukin-6 (IL-6), soluble Tumor Necrosis Factor (sTNFR), and Immunoglobulin G (IgG) response to cytomegalovirus (CMV). We also examined racial/ethnic differences.

Findings
Individuals that identified as racial/ethnic minorities were more likely to experience parental/caregiver loss and parental separation in early life compared to Non-Hispanic Whites, and had poorer immune function in late-life. We found consistent associations between experiencing parental/caregiver loss and separation and poor immune function measured by CMV IgG levels and IL-6 across all racial/ethnic subgroups. For example, among Non-Hispanic Blacks, those that experienced parental/caregiver death before age 16 had a 26% increase in CMV IgG antibodies in late-life (β = 1.26; 95% CI: 1.17, 1.34) compared to a 3% increase in CMV antibodies among Non-Hispanic Whites (β = 1.03; 95% CI: 0.99, 1.07) controlling for age, gender, and parental education.

Interpretation
Our results suggest a durable association between experiencing early life trauma and immune health in late-life, and that structural forces may shape the ways in which these relationships unfold over the life course.
Seksio Sesarea pada Wanita G2P1A0 Hamil Aterm dengan Confirmed COVID-19 Disertai Diabetes Mellitus Dalam Terapi Insulin dan HIV Positif
Authors: Wicaksono Satrio Adi , Nugroho Taufik Eko 
Published: June 2023

Latar Belakang: Coronavirus disease 2019 (COVID-19) adalah penyakit sistem pernapasan akut yang disebabkan oleh virus corona jenis baru (SARS-CoV-2) yang pertama kali ditemukan pada bulan Desember 2019 di Wuhan, Provinsi Hubei, China. Beberapa penyakit salah satunya diabetes mellitus, menjadi penyakit predisposisi perjalanan penyakit yang berat dan meningkatkan risiko kematian akibat COVID-19. Penderita COVID-19, terlebih yang memiliki predisposisi penyakit lain seperti diabetes mellitus dan HIV, menjadi hal yang perlu diperhatikan dalam pengelolaan perioperatif. Laporan kasus ini akan membahas teknik anestesi yang dipilih pada pasien ini, yang mana pasien dalam kondisi hamil, dengan COVID-19, diabetes mellitus, dan HIV positif.Kasus: Kami melaporkan sebuah kasus, seorang wanita 31 tahun dengan diagnosis G2P1A0 hamil aterm dirujuk ke RSUP Dr. Kariadi dengan HIV positif diabetes mellitus on insulin, bekas seksio sesarea, penderita dalam pengawasan (PDP) COVID-19. Penderita memiliki riwayat diabetes mellitus dengan insulin sejak 6 tahun lalu dan dinyatakan positif HIV sejak tahun 2019. Penderita memiliki keluhan batuk kering sejak 1 bulan yang lalu. Pada pemeriksaan fisik didapatkan keadaan umum penderita tampak baik dengan kesadaran composmentis, tanda vital dalam batas normal. Swab antigen COVID-19 dinyatakan positif. Pada pemeriksaan laboratorium didapatkan keadaan anemia ringan dan hiponatremia. Penderita menjalani operasi seksio sesarea dengan anestesi spinal.Pembahasan: Sebelum operasi, selama operasi dan pascaoperasi seksio sesarea, hemodinamik penderita dalam keadaan stabil, hasil lab gula darah didapatkan hasil normal. Penderita kemudian dirawat di ruangan dengan perawatan isolasi COVID-19.Kesimpulan: Anestesi regional merupakan pilihan untuk penderita dengan COVID-19 bila memungkinkan. Teknik anestesi regional yang tepat dapat menjaga fungsi pernapasan dan menghindari aerosolisasi untuk mencegah penularan virus COVID-19 dengan tetap memperhatikan level Alat Pelindung Diri dan penggunaan ruangan bertekanan negatif. Obat-obat anestesi umum dapat berbahaya bila berinteraksi dengan obat HIV, maka dari itu, anestesi regional lebih dipilih.
Pojmové zakotvení modelu spirituální gramotnosti v českém pedagogickém prostoru a možnosti její kultivace ve školním prostředí
Authors: Jirásek Ivo 
Published: June 2023

Studie s využitím metody pojmové analýzy zdůrazňuje téma spirituální gramotnosti (jako rozvoje specifické duchovní osobnostní kvality jedince) ve veřejném sekulárním školství. Spirituální dimenze je součástí lidského způsobu bytí a neměla by být zaměňována za religiózní vztah k posvátnému. Vyjevuje se ve čtyřech typech vztahů, přičemž první je vztahem k sobě s důrazem na schopnosti sebereflexe a kladení otázek po smyslu života. Druhý je vztahem k lidem v přátelském a láskyplném postoji. Třetí zakládá vztah k přírodě v modu spřízněnosti a citlivosti. A čtvrtý je přesahem zažívaným v údivu a úžasu při transcendenci zakoušené v transformativních prožitcích. Příspěvek závěrem upozorňuje na vybrané možnosti, jimiž lze spirituální gramotnost kultivovat ve veřejném školství s ohledem na věkové dispozice dětí a mládeže.
Effects of beetroot juice supplementation on vascular functional and structural changes in aged mice
Authors: Tawa Masashi , Nakagawa Keisuke , Ohkita Mamoru 
Published: June 2023

AbstractThis study investigated whether beetroot juice (BRJ) ingestion ameliorates aging‐induced functional and structural changes in vasculature. Aged mice (98–100 weeks old) were supplemented with BRJ (nitrate: 3.5 mmol/L) or drinking water for 4 weeks and compared with young mice (12–15 weeks old). The vasorelaxant response of isolated aortas to acetylcholine was markedly weaker in aged mice than in young mice, but the attenuated relaxation was significantly improved in BRJ‐supplemented aged mice. The acetylcholine‐induced relaxation was completely abolished by Nω‐nitro‐l‐arginine methyl ester in all groups. Additionally, the response to sodium nitroprusside was comparable among the three groups. The aortic medial thickness was significantly greater in aged mice than in young mice, and BRJ supplementation did not suppress this thickening. Plasma nitrate levels were significantly higher in BRJ‐supplemented aged mice than in non‐supplemented aged mice. Conversely, non‐supplemented aged mice had high plasma levels of thiobarbituric acid‐reactive substances, but the levels were suppressed in BRJ‐supplemented aged mice. These findings suggest that BRJ ingestion improves vascular endothelial dysfunction associated with aging, at least in part, by enhancing nitric oxide bioavailability and reducing oxidative stress. Therefore, beetroot ingestion may be a highly useful self‐medication option to prevent vascular aging.
Inhibition of TAZ impairs the migration ability of melanoma cells
Authors: Zhang Hao , Tu Leijing , Ma Zhouji , Lin Yue , Tan Qian 
Published: June 2023

Abstract
Malignant melanoma (MM) is characterized by rapid growth, frequent metastasis, and high mortality. Targeted therapy for MM is still a research hotspot due to the increasing understanding of the hippo pathway. The aim of this study is to investigate the role of transcriptional coactivator with PDZ-binding motif (TAZ) in MM tumorigenesis. Based on the database analysis, we found that the median mRNA expression of TAZ (5.4) was found to be similar to that of YAP (5.5) in 473 human melanoma specimens. However, in 63 MM cell lines, the median expression of TAZ (10.8) was expressed at a higher level than that of YAP (9.5), which was then validated in A375. TAZ down-regulation by siRNA decreased the migration (72%) and invasion (74%) abilities of A375. Furthermore, the down-regulation of TAZ inhibited the proliferation of A375 without affecting apoptosis. We subsequently blocked hippo signaling with verteporfin and found that verteporfin application decreased the number of migrating (63%) and invading (69%) cells, respectively. We further found that Cyr61 declined following TAZ down-regulation. Moreover, TAZ negatively correlates with melanoma patient’s overall survival. Our data proved that TAZ contributed to MM metastasis, which might be a potential therapeutic target in the future.
Urine transfer devices may impact urinary particle results: a pre-analytical study
Authors: Debunne Nathan , Delanghe Joris , Raman Leen , Oyaert Matthijs 
Published: June 2023

Abstract

Objectives
Well-standardized procedures in the pre-analytical phase of urine diagnostics is of utmost importance to obtain reliable results. We investigated the effect of different urine collection methods and the associated urine transfer tubes on urine test strip and particle results.

Methods
In total, 146 selected urine samples were subdivided into three different collection containers and subsequently transferred into its accompanying transfer tube (BD, Greiner, Sarstedt vacuum and Sarstedt aspiration). As reference, the original urine sample was directly measured on the analyser. Both chemical test strip analysis (Sysmex UC-3500) and fluorescence flow cytometry particle analysis (Sysmex UF-5000) were performed on all samples.

Results
No statistically significant differences in test strip results were found between the studied transfer methods. On the contrary, transfer of urine samples to the secondary tubes affected their particle counts. Clinically significant reductions in counts of renal tubular epithelial cells and hyaline casts were observed using the BD and Greiner transfer tubes and in counts of pathological casts using the BD, Greiner and Sarstedt vacuum tubes.

Conclusions
The results of this study indicate that the use of urine transfer tubes may impact counts of fragile urine particles. Clinical laboratories need to be aware about the variation that urine collection methods can induce on urine particle counts.
Tuning of PID controllers for unstable first-order plus dead time systems
Authors: Bi Jianyu , Tan Wen , Yu Mei 
Published: June 2023

Abstract
In this paper, proportional-integral-derivative (PID) controllers are tuned for unstable first-order plus dead time (UFOPDT) systems. Genetic algorithm (GA) is used to find the parameters of the PID controller for UFOPDT systems under the constraint of robustness measure. By curve fitting, the controller parameters are expressed as the functions of the UFOPDT model parameters. Two tuning formulas which consider robustness and the tradeoff between disturbance rejection and robustness of the closed-loop system are proposed. The proposed tuning formulas extend the application range of the existing methods and simulation results show that the tuned PID controllers can achieve good performance for UFOPDT systems.
On some geometric results for generalized k-Bessel functions
Authors: Toklu Evrim 
Published: June 2023

Abstract
The main aim of this article is to present some novel geometric properties for three distinct normalizations of the generalized

k

k

-Bessel functions, such as the radii of uniform convexity and of

α

\alpha

-convexity. In addition, we show that the radii of

α

\alpha

-convexity remain in between the radii of starlikeness and convexity, in the case when

α
∈

[

0
,
1

]

,

\alpha \in {[}0,1],

and they are decreasing with respect to the parameter

α
.

\alpha .

The key tools in the proof of our main results are infinite product representations for normalized

k

k

-Bessel functions and some properties of real zeros of these functions.
Multicenter evaluation of a method to identify delayed diagnosis of diabetic ketoacidosis and sepsis in administrative data
Authors: Michelson Kenneth A. , Bachur Richard G. , Cruz Andrea T. , Grubenhoff Joseph A. , Reeves Scott D. , Chaudhari Pradip P. , Monuteaux Michael C. , Dart Arianna H. , Finkelstein Jonathan A. 
Published: June 2023

Abstract

Objectives
To derive a method of automated identification of delayed diagnosis of two serious pediatric conditions seen in the emergency department (ED): new-onset diabetic ketoacidosis (DKA) and sepsis.

Methods
Patients under 21 years old from five pediatric EDs were included if they had two encounters within 7 days, the second resulting in a diagnosis of DKA or sepsis. The main outcome was delayed diagnosis based on detailed health record review using a validated rubric. Using logistic regression, we derived a decision rule evaluating the likelihood of delayed diagnosis using only characteristics available in administrative data. Test characteristics at a maximal accuracy threshold were determined.

Results
Delayed diagnosis was present in 41/46 (89 %) of DKA patients seen twice within 7 days. Because of the high rate of delayed diagnosis, no characteristic we tested added predictive power beyond the presence of a revisit. For sepsis, 109/646 (17 %) of patients were deemed to have a delay in diagnosis. Fewer days between ED encounters was the most important characteristic associated with delayed diagnosis. In sepsis, our final model had a sensitivity for delayed diagnosis of 83.5 % (95 % confidence interval 75.2–89.9) and specificity of 61.3 % (95 % confidence interval 56.0–65.4).

Conclusions
Children with delayed diagnosis of DKA can be identified by having a revisit within 7 days. Many children with delayed diagnosis of sepsis may be identified using this approach with low specificity, indicating the need for manual case review.
Russian War, Neocolonialism and Holocaust Studies in Ukraine
Authors: Dolhanov Petro 
Published: June 2023

Abstract
This text is related to the theme of the usage of historical narratives about WWII in the current Russian War against Ukraine. It is a brief analysis of the instrumentalisation of Holocaust history in Russian propaganda, as well as the role of historians as enablers in these processes. The essay also focuses on the issue of decolonization of historical narratives in Western academia and Ukrainian discourses of WWII in the context of the Russian–Ukrainian War. The final issue discussed in this text concerns how Russian aggression in Ukraine has affected academic studies and research on the history of the Holocaust in Ukraine and EU countries.
Un commento di età imperiale al libro secondo dell’Etica Nicomachea. Traduzione con introduzione e note
Authors: Natali Carlo 
Published: June 2023

Abstract
We present here the first translation into a modern language of the anonymous commentary on the second book of the Nicomachean Ethics. It is an evidence of the style of exegetical work that was being done in the Peripatetic schools during the 2nd–3rd century AD, and a testimony to a particular version of 2nd century Aristotelianism. Even if the comment is not continuous, one gets the impression of listening to a good lecturer illustrating Aristotle’s text. He paraphrases it at times, makes comparisons with other passages of the corpus, illustrates the structure and the logic of the discourse, and shows the difference between Aristotle’s positions and those of other schools. In the most theoretically interesting parts of the commentary the anonymous discusses aporiai, and opposes Aristotle’s ethical theories to other schools, especially to the Stoics.
On Plato’s Precosmos (Ti. 52d2–53c3)
Authors: Petrucci Federico M. 
Published: June 2023

Abstract
The aim of this paper is to provide a new reading of Plato’s precosmos (Ti. 52d2–53c3). More specifically, I shall argue that the precosmos is populated by bodies deriving from random complexes of properties, and that this is the effect of the Receptacle’s full precosmic participation in the Paradigm. This will turn out to be consistent with a robust notion of ‘precosmic generation’ and will reveal why Plato may have sought to refer to this otherwise puzzling scenario: representing the precosmos in this way allows Plato to effectively justify why the Demiurge is responsible only for the goodness and perfection of the universe, and why it is properly the best possible cause.
L’interprétation astrologique de la philosophie naturelle d’Aristote selon Alexandre d’Aphrodise et Bardesane le Syrien
Authors: Jurasz Izabela 
Published: June 2023

Abstract
The existence of common points between Alexander of Aphrodise and Bardaisan the Syrian has been pointed out on various occasions. However, this question has not been explored in depth. The article proposes to analyse the cosmological ideas of Alexander and Bardaisan. Because both authors are known for their anti-determinist and anti-astrological polemics, it is preferable to place this comparison in the context of the astrological interpretation of Aristotle’s natural philosophy. The article discusses the Aristotelianism of Bardaisan, who may be the first representative of the reception of this doctrine in Syriac.
Notes on Prior Analytics II 22.68a16–21
Authors: Zanichelli Riccardo 
Published: June 2023

Abstract
At Prior Analytics II 22.68a16–21, Aristotle argues that if A is predicated of all B and C and nothing else, and B is predicated of all C, then A and B convert. In justifying his argument, however, he appears to claim that B is not predicated of all A. This claim has long been a cause of puzzlement to commentators. A widespread view is that the kind of conversion discussed in the passage at issue should be explained in both extensional and intensional terms. After providing some textual evidence that Aristotle only apparently claims that B is not predicated of all A, I give a purely extensional account of Aristotle’s argument. This account is plausible, conservative and simpler than any of the intensional accounts that have been proposed so far.
Stanza-based networks for poetic texts: a pilot study
Authors: Buk Solomija , Rovenchak Andrij 
Published: June 2023

Abstract
We use approaches from the theory of complex networks to analyze the Prologue to Moses, a poem by the Ukrainian writer and scholar Ivan Franko. The Ukrainian text (in the original orthography from 1905 and the modern one) and several translations into Polish, English, French, German, Italian, Portuguese, Slovak, and Spanish are studied. Networks are built in a manner that links are drawn between words (considered network vertices) within a stanza. Seven network parameters are calculated: all-degree centralization, assortativity, average path length, betweenness, clustering coefficient, density, and transitivity. Their dynamics is analyzed as the vertices with the highest numbers of links are removed from the networks one by one. The data obtained for the human-made translations are compared to those based on machine translations generated by the Google Translate service. Peculiarities of certain translations are underlined. Tentative correlation between the values of parameters and levels of language analyticity/syntheticity are established. Prospects toward automatic lemmatization and related problems to be solved are briefly outlined.
Incidental collocational learning from reading-while-listening and the impact of synchronized textual enhancement
Authors: Jung Jookyoung , Lee Minjin 
Published: June 2023

Abstract
The present study explored if textual enhancement would promote incidental learning of collocations from reading-while-listening, and if synchronizing the timing of textual enhancement to the audio could affect the efficacy of textual enhancement. Fifty-six Korean speakers engaged in reading-while-listening of two English stories under one of three conditions: no enhancement, target collocations coloured in red, and target collocations dynamically turning to red in synchronization with the audio. The target collocations were 12 adjective-pseudonoun pairs, and participants’ learning was measured with a series of recall and recognition tests on pseudonoun form, meaning, and collocations, recording both response accuracy and latency. The results from mixed-effects modeling revealed that both colouring conditions promoted receptive knowledge about the target collocations, and synchronized colouring further boosted semantic processing of the pseudonouns. The findings indicate that synchronization between textual and audio input could be a useful catalyst to encourage deeper engagement with the enhanced features.
Fibroblast growth factor 23 levels in cord and peripheral blood during early neonatal period as possible predictors of affected offspring of X-linked hypophosphatemic rickets: report of three female cases from two pedigrees
Authors: Nabeshima Yukiyo , Sato Takeshi , Zukeran Hiroaki , Komatsu Rieko , Nakano Satsuki , Ichihashi Yosuke , Tominaga Takahiro , Miwa Masayuki , Amano Naoko , Ishii Tomohiro , Hasegawa Tomonobu 
Published: June 2023

Abstract

Objectives
The role of serum fibroblast growth factor 23 (FGF23) level in early neonatal period on the diagnosis of X-linked hypophosphatemic rickets (XLH) remains unclear.

Case presentation
Two female patients from the first pedigree had an affected mother, and the other female from the second pedigree had an affected father. In all three cases, FGF23 levels were high in cord blood and peripheral blood at day 4-5. Additionally, the FGF23 levels considerably increased from birth to day 4-5. We identified a PHEX pathogenic variant and initiated treatment during infancy in each case.

Conclusions
In neonates with a parent diagnosed as PHEX-associated XLH, FGF23 in cord blood and peripheral blood at day 4-5 may be useful markers for predicting the presence of XLH.
How to Become a Good Artist – Kant on Humaniora and the ‘Propaedeutic for All Beautiful Art’
Authors: Berger Larissa 
Published: June 2023

AbstractIn § 60 of theCritique of Judgment, entitled ‘On the doctrine of method of taste,’ Kant suggests that the study of so-calledhumaniora(ancient Roman and Greek literature) will help one to become a good artist. I will argue that a proper, namely emotional, engagement withhumaniorawill further the two components of humanity in ourselves: the feeling of sympathy and the ability to communicate feelings. I will discuss two options of how a strengthening of these two components might contribute to the creation of good artworks: it will help one to create artworks that arouse the universal communicable pleasure in the beautiful, or it will help one to create artworks that arouse sympathetic feelings. Siding with the latter option, I will argue that emotions can contribute to the enlivening of aesthetic ideas and, thus, to good art.
Terahertz all-silicon metasurfaces with off-axis bifocal characteristics for polarization detection
Authors: Li Hui , Duan Shouxin , Zheng Chenglong , Xu Hang , Li Jie , Song Chunyu , Yang Fan , Shi Wei , Zhang Yating , Shen Yun , Yao Jianquan 
Published: June 2023

Abstract
Functional devices for terahertz (THz) polarization detection in transmission mode are highly desired in integrated applications, but traditional polarization measurement systems are bulky and highly cost. The combination between all-silicon metasurfaces and focused beams carrying polarization information has offered a new opportunity for miniaturized polarization detection behavior. Here, we investigate and experimentally demonstrate a new scheme for realizing efficiently miniaturized polarization detection behavior based on the polarization multiplexing encoding technique. The full-Stokes parameter matrix of the incident polarization state can be reconstructed in a single snapshot by using a microprobe to record, pixel by pixel, the complex amplitude information contained in a pre-designed plane. Subsequently, the polarization detection capability of the proposed design principle is evaluated using random polarization states defined on the surface of a standard Poincaré sphere (PS). Such a scheme offers potential applications for the development of compact photonic meta-platforms for polarization detection in transmission mode, being highly favored in polarization high-resolution imaging, remote sensing, and THz communications.