bluuebunny/crossref_metadata_2025_split huggingface dataset:
Herbal rodent repellent: a dependable and dynamic approach in defiance of synthetic repellent
Authors: Quasim Md. Asad , Karn Abhishek Kumar , Paul Sujata , Hmar El Bethel Lalthavel , Sharma Hemanta Kumar 
Published: June 2023

Abstract
Background
Rodents are the most common and diverse order of mammals, the most troublesome pest in agriculture, gardening, forestry, and public products, and to blame for the spread of many illnesses to humans and animals. In terms of rodenticidal exposure, rodenticide use is only to kill the rodent, not to repel it. On the other hand, herbal rodent repellents are compounds that, by taste, odour, or both, keep rodents away from human habitat and prevent diseases spread due to them. Herbal rodent repellents are more potent, economical, biodegradable, and do not persist in the soil or water, and they also have a broad range of other biological properties.

Main body of the abstract
Rodents are a prevalent and harmful pest that accounts for more than 2277 species distributed all over the world. The growing public awareness of the ethical and animal welfare problems associated with traditional pest animal control methods has progressively switched to non-lethal alternatives for the management of rodents. This article promotes herbal rodent repellents due to the various reported toxic effects of synthetic rodenticides on human health and the environment. The review discusses some of the important herbs that have the potency to repel rodents thereby raising awareness for the use of non-toxic methods for pest control. Data from different database like PubMed, Google Scholar, Research Gate, PLOS One, and others were retrieved, and then, an extensive literature review was carried out to prepare the article.

Short conclusion
From the information provided, it can be concluded that rodenticide poisoning could cause a serious public health issue with a high case death rate. Increasing public understanding of rodenticide toxicity, as well as stringent monitoring of rodenticide sales and use, might assist to reduce indiscriminate use and poisoning. Therefore, herbal rodent repellents, due to their least toxicity, could provide a safe and dynamic approach over the use of synthetic rodenticides.
A persistent median artery piercing the median nerve: a review and clinical implications
Authors: Pavlovsky Ethan , Kistner Gilberto , Loomis Mario 
Published: June 2023

Abstract
Background
This case report documents a rare variation of a persistent median artery. Normally a transient vessel present during embryologic development of the limbs, the median artery typically regresses by the eighth week of life as the radial and ulnar arteries predominate the distal vascular supply of the hand. In a subset of the adult population, this artery remains as a persistent median artery which most often ends in the carpal tunnel or hand without significant vascular dependence.

Case presentation
An 84-year-old female cadaver was found bilaterally to have an artery that penetrated the median nerve in the forearm, continued through the carpal tunnel, then joined the superficial arch, giving rise to the common digital artery to the second webspace. It also gave rise to the radialis indicis, the princeps pollicis, and an anastomotic branch to the radial artery.

Conclusions
This anatomic variant of a persistent median artery piercing the median nerve, traversing the carpal tunnel, and providing aberrant primary blood supply to a large area of the hand are details clinically relevant to those who treat hand disorders and injuries.
Key roles of amylopectin synthesis and degradation enzymes in the establishment and reactivation of chronic toxoplasmosis
Authors: Chen Pu , Lyu Congcong , Wang Yidan , Pan Ming , Lin Xingyu , Shen Bang 
Published: June 2023

AbstractToxoplasma gondii (T. gondii) is an obligate intracellular parasite with a wide range of hosts, including humans and many warm-blooded animals. The parasite exists in two interconvertible forms, namely tachyzoites and bradyzoites in intermediate hosts that are responsible for acute and chronic infections respectively. Mature bradyzoites accumulate large amounts of amylopectin granules but their roles have not been fully characterized. In this study, the predicted key enzymes involved in amylopectin synthesis (UDP-sugar pyrophospharylase, USP) and degradation (alpha-glucan water dikinase, GWD) of ME49 strain were individually knocked out, and then bradyzoite-related phenotyping experiments in vitro and in vivo were performed to dissect their roles during parasite growth and development. Deletion of the usp or gwd gene in the type II strain ME49 reduced the replication rates of tachyzoites in vitro and parasite virulence in vivo, suggesting that amylopectin metabolism is important for optimal tachyzoite growth. Interestingly, the Δusp mutant grew slightly faster than the parental strain under stress conditions that induced bradyzoite transition, which was likely due to the decreased efficiency of bradyzoite formation of the Δusp mutant. Although the Δgwd mutant could convert to bradyzoite robustly in vitro, it was significantly impaired in establishing chronic infection in vivo. Both the Δusp and Δgwd mutants showed a dramatic reduction in the reactivation of chronic infection in an in vitro model. Together, these results suggest that USP and GWD, which are involved in amylopectin synthesis and degradation have important roles in tachyzoite growth, as well as in the formation and reactivation of bradyzoites in T. gondii.
Inflamed Adipose Tissue: Therapeutic Targets for Obesity-related Endothelial Injury
Authors: Dai Wanlin , Liu Ziqi , Yang Shaojie , Kong Jing 
Published: June 2023

Abstract
Cardiovascular disease (CVD) is the leading cause of death worldwide and is primarily associated with obesity, visceral adiposity, and unhealthy perivascular adipose tissue (PVAT). The inflammatory polarization of immune cells residing in adipose tissue and abnormal levels of adipose-related cytokines are crucial factors contributing to the pathogenesis of metabolic disorders. We reviewed the most relevant papers in the English literature regarding PVAT and obesity-related inflammation and CVD, aiming to explore potential therapeutic targets for metabolic alterations related to CV health. Such an understanding will help determine the pathogenetic relationship between obesity and vascular injury in efforts to ameliorate obesity-related inflammatory responses. In the context of obesity, dysregulation of adipose tissue immune function, which consists of immune cells and adipose-derived cytokines, plays a crucial role in vascular injury and endothelial dysfunction, especially the PVAT. Metabolic changes between typical VAT and PVAT in obese conditions would be beneficial in improving the risk of obesity-induced endothelial dysfunction and CVDs.
Herpes Simplex Virus Diencephalitis Leading to Panhypopituitarism
Authors: Casey Caoimhe , O’Connor Antoinette , Cronin Simon , Tuthill Antoinette 
Published: June 2023

Abstract
Herpes simplex virus (HSV) is one of the most common causes of viral encephalitis. Hypothalamic-pituitary dysfunction has rarely been reported in HSV encephalitis, with few reports into the longer term outcomes for these patients. A 46-year-old male presented with a 10-day history of delirium, fever, and polydipsia. Initial computed tomography of the brain and cerebrospinal fluid cell counts were normal. Magnetic resonance imaging showed T2-hyperintensity affecting bilateral infundibuli, hypothalami, subthalamic nuclei, and optic radiations. Serial cerebrospinal fluid detected HSV1 DNA and we diagnosed him with HSV diencephalitis. He had marked biochemical abnormalities from the outset, with dramatic changes in serum sodium levels. He was ultimately diagnosed with permanent central diabetes insipidus and panhypopituitarism following evidence of central hypothyroidism, hypogonadotrophic hypogonadism, and a flat cortisol response to an insulin tolerance test. Neurocognitive recovery took several months, but subtle deficits in executive function and information processing remain. Hypothalamic hyperphagia developed as well as temperature dysregulation. He requires lifelong hormonal replacement and is undergoing regular endocrine follow up. This case highlights hypothalamic-pituitary dysfunction as a rare endocrine complication of HSV diencephalitis and illustrates the complexity of managing this in the long term.
Infrastructures of Aging: Form and Institutional Care in Dementia Fiction
Authors: Vermeulen Pieter 
Published: June 2023

Abstract
The fictional representation of the cognitive experience of people with dementia is often credited with providing an occasion for readerly empathy and a privileged mimetic account of dementia experience. This essay draws on recent scholarship by Caroline Levine and Anna Kornbluh that expands the notion of form to include infrastructures, institutions, and other entities that provide sustenance and continuity to offer a different account of the cultural work such fictions do. The essay argues that two canonical works of fiction about dementia— J. Bernlef's Out of Mind and B. S. Johnson's House Mother Normal—do not merely offer a mimesis of dementia experience (the focus of existing research). These works take seriously dementia experience's challenge to formal coherence as they (however ambivalently) displace the task of providing continuity and sustenance to caring institutions rather than to residual ratiocinative capacities. Both novels repurpose the ellipses and blanks that are typical of the representation of dementia “mind styles” for something other than an indication of deficient subjectivity: in Bernlef, they become an indicator of lyrical and timeless sustenance and suspension; in Johnson, they point to regularities that invite the reader to coconstruct an imaginative space that sustains the lives the novel evokes.
Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes
Authors: Sundaramurthi Husvinee , Tonelotto Valentina , Wynne Kieran , O'Connell Fiona , O’Reilly Eve , Costa-Garcia Marcel , Kovácsházi Csenger , Kittel Agnes , Marcone Simone , Blanco Alfonso , Pallinger Eva , Hambalkó Szabolcs , Piulats Rodriguez Jose Maria , Ferdinandy Péter , O'Sullivan Jacintha , Matallanas David , Jensen Lasse D. , Giricz Zoltán , Kennedy Breandán N. 
Published: June 2023

Background: Uveal melanoma is a poor prognosis cancer. Ergolide, a sesquiterpene lactone isolated from Inula Brittanica, exerts anti-cancer properties. The objective of this study was to 1) evaluate whether ergolide reduced metastatic uveal melanoma (MUM) cell survival/viability in vitro and in vivo; and 2) to understand the molecular mechanism of ergolide action. Methods: Ergolide bioactivity was screened via long-term proliferation assay in UM/MUM cells and in zebrafish MUM xenograft models. Mass spectrometry profiled proteins modulated by ergolide within whole cell or extracellular vesicle (EVs) lysates of the OMM2.5 MUM cell line. Protein expression was analyzed by immunoblots and correlation analyses to UM patient survival used The Cancer Genome Atlas (TCGA) data. Results: Ergolide treatment resulted in significant, dose-dependent reductions (48.5 to 99.9%; p<0.0001) in OMM2.5 cell survival in vitro and of normalized primary zebrafish xenograft fluorescence (56%; p<0.0001) in vivo, compared to vehicle controls. Proteome-profiling of ergolide-treated OMM2.5 cells, identified 5023 proteins, with 52 and 55 proteins significantly altered at 4 and 24 hours, respectively (p<0.05; fold-change >1.2). Immunoblotting of heme oxygenase 1 (HMOX1) and growth/differentiation factor 15 (GDF15) corroborated the proteomic data. Additional proteomics of EVs isolated from OMM2.5 cells treated with ergolide, detected 2931 proteins. There was a large overlap with EV proteins annotated within the Vesiclepedia compendium. Within the differentially expressed proteins, the proteasomal pathway was primarily altered. Interestingly, BRCA2 and CDKN1A Interacting Protein (BCCIP) and Chitinase Domain Containing 1 (CHID1), were the only proteins significantly differentially expressed by ergolide in both the OMM2.5 cellular and EV isolates and they displayed inverse differential expression in the cells versus the EVs. Conclusions: Ergolide is a novel, promising anti-proliferative agent for UM/MUM. Proteomic profiling of OMM2.5 cellular/EV lysates identified candidate pathways elucidating the action of ergolide and putative biomarkers of UM, that require further examination.
Electronic Payment Technology and Business Finance: A Randomized, Controlled Trial with Mobile Money
Authors: Dalton Patricio S. , Pamuk Haki , Ramrattan Ravindra , Uras Burak , van Soest Daan 
Published: June 2023

We conducted a randomized, controlled trial with small- and medium-sized enterprises in Kenya to estimate the causal impact of an electronic payment (e-payment) technology on business finance. Using an encouragement design, we exogenously increased e-payment usage among a random subset of firms by relaxing adoption transaction costs and information barriers. Sixteen months after the intervention, we find that the e-payment technology increased access to mobile loans (in the number of loans as well as in the amount borrowed) by at least 50% (0.17 standard deviation), likely because of the reduction of information asymmetries brought by an increase in digital transactions. We find no effect of the e-payment technology on sales and profits, but we do find a reduction of sales volatility and precautionary investment, especially for smaller firms. This suggests that mobile loans help smaller firms cope with short-term negative shocks. We provide a stylized model of business finance that rationalizes these findings. This paper was accepted by Bruno Biais, finance. Funding: This paper was produced under the framework of the “Enabling Innovation and Productivity Growth in Low Income Countries (EIP-LIC/PO5639)” project, funded by the Department for International Development (DFID) of the United Kingdom and implemented by Tilburg University. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4821 .
The Irrelevance of Environmental, Social, and Governance Disclosure to Retail Investors
Authors: Moss Austin , Naughton James P. , Wang Clare 
Published: June 2023

Using an hourly data set on retail investor individual security positions from Robinhood Markets, we find no evidence that environmental, social, and governance (ESG) disclosures inform retail investors’ buy and sell decisions. The response on ESG press release days by retail investors is indistinguishable from nonevent days. In contrast, these same investors make economically meaningful changes to their portfolios in response to non-ESG press releases, especially those that pertain to earnings announcements. We use stock return tests to show that there is economic content in ESG press releases, and we conduct subsample analyses showing that retail investors do not respond to the most salient and economically transparent ESG disclosures. Collectively, these tests suggest that a lack of economic content, a lack of visibility, and difficulty with investment integration are unlikely to explain our findings. This paper was accepted by Suraj Srinivasan, accounting. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.4822 .
High-absorption optical stack for aluminum kinetic inductance detectors
Authors: Mai Zhanzhang , Dai Xucheng , Chen Yingni , Shi Zhongyu , Wang Haoyu , Pan Changzhao , Liu Xuming , Wang Zhao , Guo Weijie , Wang Yiwen 
Published: June 2023

We present a high-absorption optical stack design for aluminum (Al)
kinetic inductance detectors (KIDs). Aluminum can be easily processed
in micro-fabrication and is the most conventional superconducting
material for KIDs. However, it is challenging to achieve high
absorption in the Al absorber because of its high reflection at
optical wavelengths. By embedding the thin Al film between an
anti-reflection (AR) coating layer and a dielectric-based distributed
Bragg reflector, we show that close-to-unity absorption can be
achieved around a single wavelength (e.g., ≈98.9% at 1518 nm). The reflection
and transmission measurements agree well with the calculation based on
the transmission matrix model. We also show our preliminary results of
absorption ≥70% in a broader wavelength range (≈230nm) with multilayer AR coatings. The
absorber design in a lumped-element KID is discussed. Our work paves
the way to high-efficiency photon-counting and energy-resolving
Al-based KIDs in the optical to NIR range.
Identifying temporal variations in burn admissions
Authors: Beyene Robel T. , Stonko David P. , Gondek Stephen P. , Morrison Jonathan J. , Dennis Bradley M. 
Published: June 2023

Background
Variations in admission patterns have been previously identified in non-elective surgical services, but minimal data on the subject exists with respect to burn admissions. Improved understanding of the temporal pattern of burn admissions could inform resource utilization and clinical staffing. We hypothesize that burn admissions have a predictable temporal distribution with regard to the time of day, day of week, and season of year in which they present.

Study design
A retrospective, cohort observational study of a single burn center from 7/1/2016 to 3/31/2021 was performed on all admissions to the burn surgery service. Demographics, burn characteristics, and temporal data of burn admissions were collected. Bivariate absolute and relative frequency data was captured and plotted for all patients who met inclusion criteria. Heat-maps were created to visually represent the relative admission frequency by time of day and day of week. Frequency analysis grouped by total body surface area against time of day and relative encounters against day of year was performed.

Results
2213 burn patient encounters were analyzed, averaging 1.28 burns per day. The nadir of burn admissions was from 07:00 and 08:00, with progressive increase in the rate of admissions over the day. Admissions peaked in the 15:00 hour and then plateaued until midnight (p<0.001). There was no association between day of week in the burn admission distribution (p>0.05), though weekend admissions skewed slightly later (p = 0.025). No annual, cyclical trend in burn admissions was identified, suggesting that there is no predictable seasonality to burn admissions, though individual holidays were not assessed.

Conclusion
Temporal variations in burn admissions exist, including a peak admission window late in the day. Furthermore, we did not find a predictable annual pattern to use in guiding staffing and resource allocation. This differs from findings in trauma, which identified admission peaks on the weekends and an annual cycle that peaks in spring and summer.
Correlation of bone density measured on CT chest with the severity of COVID-19 infection: A retrospective study
Authors: Bakhsh Noha , Banjar Mai , Baig Mukhtiar 
Published: June 2023

Purpose
This retrospective study investigated the correlation between bone mineral density (BMD) and COVID-19 severity among COVID-19 patients who underwent chest computed tomography (CT) scans.

Methods
This study was carried out at the King Abdullah Medical Complex in Jeddah, Saudi Arabia, one of the largest COVID-19 centers in the western province. All adult COVID-19 patients who had a chest CT between January 2020 and April 2022 were included in the study. The pulmonary severity scores (PSS) and vertebral BMD measurements were obtained from the patient’s CT chest. Data from the patients’ electronic records were collected.

Results
The average patient age was 56.4 years, and most (73.5%) patients were men. Diabetes (n = 66, 48.5%), hypertension (n = 56, 41.2%), and coronary artery disease (n = 17, 12.5%) were the most prevalent comorbidities. Approximately two-thirds of hospitalized patients required ICU admission (64%), and one-third died (30%). The average length of stay in the hospital was 28.4 days. The mean CT pneumonia severity score (PSS) was 10.6 at the time of admission. Patients with lower vertebral BMD (< = 100) numbered 12 (8.8%), while those with higher vertebral BMD (>100) numbered 124 (91.2%). Only 46 out of the total survived patients (n = 95) were admitted to the ICU versus all deceased (P<0.01). The logistic regression analysis revealed that an elevated PSS upon admission resulted in a reduced chance of survival. Age, gender, and BMD did not predict survival chances.

Conclusion
The BMD had no prognostic advantage, and the PSS was the significant factor that could have predicted the outcome.
Effects of acupuncture on earthquake survivors with major psychiatric disorders and related symptoms: A scoping review of clinical studies
Authors: Kwon Chan-Young , Leem Jungtae , Kim Da-Woon , Kwon Hui-Ju , Park Hyun-Seo , Kim Sang-Ho 
Published: June 2023

Background
This scoping review aimed to determine the current research status of acupuncture for major psychiatric disorder (MPD) in earthquake survivors.

Method
We followed the scoping review process described previously. A literature search on 14 electronic databases was conducted from inception to November 29, 2022. Data from the included studies were collected and descriptively analyzed to address our research question. Extracted data were collated, synthesized, and summarized the according to the analytical framework of a scoping review.

Result
This scoping review included nine clinical studies: four randomized controlled trials (RCTs) and five before–after studies. The most frequent MPD type among the included acupuncture studies was posttraumatic stress disorder (PTSD; 6/9, 66.67%). The most frequent acupuncture type was scalp electro-acupuncture (4/9, 44.44%), followed by manual acupuncture and ear acupressure/ear acupuncture (3/9, 33.33%). Studies using scalp electro-acupuncture all used common acupoints, including GB20, GV20, GV24, and EX-HN1. In general, the treatment period lasted between 4 and 12 weeks. Validated assessment tools for PTSD severity and accompanying symptoms were used for patients with PTSD, while the corresponding evaluation tools were used for patients with other diagnoses or clinical symptoms. Acupuncture-related adverse events were generally mild and temporary, such as mild bleeding and hematoma, and syncope was a rare but potentially serious adverse event (1/48 patients and 1/864 sessions over a treatment period of 4 weeks).

Conclusion
Acupuncture studies for MPD after an earthquake mainly focused on PTSD. RCTs accounted for around half of the included studies. Scalp electro-acupuncture was the most common acupuncture type, and EX-HN1 and GV24 were the most important acupoints in the acupuncture procedures for MPD. The included studies mostly used validated symptom assessment tools, though some did not. Clinical studies in this field need to be further expanded regardless of the study type.

Protocol registration
https://osf.io/wfru7/.