bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finite Element Investigation of Cutting Speed Effects on the Machining of Ti6Al4V Alloy
Authors: Pal Surinder , Velay Xavier , Saleem Waqas 
Published: August 2023

Abstract
In modern times, titanium alloy has a great application prospect in the medical field. Still, the pitiful machinability of titanium alloy material brings incredible difficulty to its ultra-precision cutting. This work presented the effect of parametric sensitivity analysis of the orthogonal cutting process using the finite element method, which dramatically enhances the cutting performance of Ti-6AL-4V. The simulation results are attained by applying Abaqus® explicit 6.14 software. The mechanical reaction of two-dimensional finite element models has been examined for cutting forces. Additionally, the impacts of rake angle, clearance angle, and nose radius on the stress distribution in orthogonal cutting of Ti-6AL-4V have been investigated. Also, to make certain numerical accuracy, the Johnson − Cook constitutive models for Ti6Al4V alloy are implemented. In the end, FE simulation outcomes were supported by the reported results in the literature.
Protective Effect of Probiotics Against Irinotecan-Induced Fatty Liver Disease: An Animal Model
Authors: ocaklı serhat , akkurt gökhan , kartal bahar , Akkurt Burcu , doğan ibrahim , yüksel bülent , çetinkaya erdinç 
Published: August 2023

Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic disease that affects approximately 25% of the global population and 20% of patients using irinotecan (IRI). Although many studies have been conducted on the treatment of NAFLD, a standard treatment method superior to diet modification and exercise has not been discovered yet. It has been shown that the use of probiotics has positive effects on diet-related fatty liver disease.
Objectives: This study aimed to investigate whether NAFLD caused by IRI, which is frequently included in the systemic treatment regimens of metastatic colon-rectum, stomach, and pancreatic tumors, can be prevented through the concomitant use of probiotics.
Methods: In this study, which was planned as an experimental animal model, four groups of eight mice each (normal saline, IRI alone, IRI + probiotics, and probiotics alone) were formed, and at the end of the seven-week period, the effect of probiotic use was examined using biochemical, histological, and immunohistochemical analyses.
Results: As a result of the examinations, a statistically significant improvement was observed in the IRI + probiotics group in terms of steatosis, lobular inflammation, hepatocyte ballooning, fibrosis, inducible nitric oxide synthase level, transforming growth factor beta level, and aspartate aminotransferase level compared to the group receiving IRI alone (p < 0.05).
Conclusions: The results obtained from this study suggest that the concomitant use of probiotics with IRI may reduce the development of fatty liver disease and steatohepatitis. Keywords: Non-alcoholic fatty liver disease, irinotecan, probiotics
Efficacy and safety of switching lamivudine-based dual therapies for the maintenance of virologic suppression in adults with HIV-1: a systematic review and network meta-analysis
Authors: Deng Boning , Deng Haiying , Chen Yajun , Jiang Zhenyu 
Published: August 2023

Abstract
Background：Based on available evidence, lamivudine-based dual therapies have been found to be effective, safe, and non-inferior to triple treatment in HIV-1 infected patients who are virologically suppressed. Because these dual therapies have fewer side effects and improved patient compliance. However, further comparisons of the efficacy and safety are still lacking among different lamivudine-based dual therapies. This study systematically assessed the efficacy and safety of switching to various lamivudine-based dual therapies.
Methods: We searched the eligible randomized controlled trials (RCTs) from electronic databases as followed: ScienceDirect, MEDLINE, EMBASE, Web of Science, Pubmed, U.S.National Library of Medicine (www.clinicaltrials.gov). Data were analyzed by network meta-analysis using the network package in Stata 15.0. On the basis of the SUCRA scores, cluster analysis was performed to evaluate the efficacy and safety of the interventions and determine the optimal therapies.
Results: A total of 7 randomized controlled trials (RCTs) involving 2539 patients were included in this study. The network meta-analysis results of different dual therapies based on lamivudine revealed that the increase in CD4 cell count from baseline was significantly higher in patients treated with DTG + 3TC compared to TT (MD=17.97, 95% CI:0.41, 35.54). However, no significant differences were observed in any other comparisons. Compared with TT alone, ATV + 3TC had the highest probability of maintaining virologic suppression, improving CD4 cell count from baseline and reducing the adverse events incidence. LPV + 3TC had the lowest rate of serious adverse events and withdrawal due to adverse events. According to the cluster analysis results, ATV + 3TC and DTG + 3TC might be the best choice concerning efficacy and safety simultaneously.
Conclusions: According to the data analysis, compared to triple treatment, lamivudine-based dual therapies might be the more favorable option in patients with an HIV-1 infection who were virologically suppressed. Among the lamivudine-based dual therapies, ATV + 3TC and DTG + 3TC might be the most favorable options for the maintenance of virologic suppression in adults with HIV-1.
Meta registration: The study protocol was registered in PROSPERO (CRD 42023387562).
Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Authors: Qian Jiang , Qian Cheng , Xin Ying , Qi Cheng , Wang Hui , Zack Donald , Blackshaw Seth , Hattar Samer , Zhou Feng-Quan 
Published: August 2023

Abstract
The progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, the extracellular environment also plays a critical role in regulating cell viability. Here we explore how intercellular communication contributes to the survival of retinal ganglion cells (RGCs) following the optic nerve crush (ONC). Although the direct effect of the ONC is restricted to the RGCs, we observed transcriptomic responses in other retinal cells to the injury based on the single-cell RNA-seq, with astrocytes and Müller glia having the most interactions with RGCs. By comparing the RGC subclasses showing distinct resilience to ONC-induced cell death, we found that the high-survival RGCs tend to have more ligand-receptor interactions with other retinal cells, suggesting that these RGCs are intrinsically programmed to foster more communication with their surroundings. Furthermore, we identified top 47 interactions that are stronger in the high-survival RGCs, likely representing neuroprotective interactions. We performed functional assays on one of the receptors, Mu-opioid receptor (Oprm1), a receptor known to play roles in regulating pain, reward, and addictive behavior. Although Oprm1 is preferentially expressed in intrinsically photosensitive retinal ganglion cells (ipRGCs), its neuroprotective effect could be transferred to multiple RGC subclasses by specific overexpressing Oprm1 in pan-RGCs in ONC, excitotoxicity, and glaucoma models. Lastly, manipulating Oprm1 activity improved visual functions and altered pupillary light response in mice. Our study provides an atlas of cell-cell interactions in both intact and post-ONC retina and an effective strategy to predict molecular mechanisms in neuroprotection, underlying the principal role played by extracellular environment in supporting neuron survival.
Spatio-Temporal Trends of Maternal and Child Health Service Utilization and Child Mortality in Poor and Rich Districts of Addis Ababa city, Ethiopia
Authors: Heyi Worku Dechassa , Mekonnen Wubegzier , Heyi Worku Dechassa , Melesse Desalegn Y. , Tejedor-Garavito Natalia , Nilsen Kristine , Getachew Theodros , Mulu Shegaw , Wondrad Naod 
Published: August 2023

Abstract
Although access and utilization of maternal, newborn, and child health (MNCH) services tend to be higher in urban areas compared to rural areas across SSA, previous studies suggest that large intra-urban inequalities exist. This study aims to examine temporal trends and spatial variations of maternal and child health service utilization between the poorest and richest districts of Addis Ababa. A World Bank district-based poverty index was used to classify districts into top 60% (non-poor) and bottom 40% (poor). Essential maternal and child health service coverage were estimated from routine health facility data for 2019–2021 and Five rounds of Ethiopian Demographic Health Survey (2000–2019) were used to estimate child mortality. Geospatial variation of the service coverage in poor and rich districts were estimated from DHIS 2 using QGIS. Results: Service coverage was substantially higher in the top 60% than bottom 40% districts. For example, four antenatal care(ANC4), skill birth attendance (SBA) and postnatal care (PNC) coverage was over 90% in the non-poor compared to 54–67% in the poor districts. Inequalities were less pronounced for childhood vaccinations with over 90% coverage levels across districts. District inequalities in mortality rates were considerable. Neonatal mortality was nearly twice as high in the bottom 40% as in the top 60% households. Similarly, the under 5 mortality rate was three times higher in the bottom 40% compared to top 60% of households. Addis Ababa has substantial inequalities in MNCH service utilization and child mortality. Greater focus on the city’s women and children living in the poorest households and districts in maternal, newborn and child health programs is urgently needed.
Unveiling Tissue Marker Migration in MRI-Guided Vacuum-Assisted Biopsies: Frequency, Factors, and Implications
Authors: Golan Orit , Lazar Sapir , Menes Tehillah , Freitas Vivianne , Kessner Rivka , Shalmon Tamar , Neeman Rina , Mercer Diego , Amitai Yoav 
Published: August 2023

Abstract
Purpose
To evaluate the frequency and factors associated with clip migration in MRI-guided breast biopsies.
Methods and materials
We retrospectively evaluated all MRI-guided biopsies performed between January 2013 and December 2020 in our institution for clip migration. Only patients with follow-up breast MRI showing the clip were included in the study. Migration was defined as > 1 cm movement from the target lesion. Migration frequency and directions were recorded. Different factors associated with clip migration were analyzed using statistical tests as appropriate.
Results
A total of 291 biopsies in 268 women were included in the study with 31 migration events recorded (11%, 95%CI 7–15). All migrations occurred along the biopsy tract, 30 of them distal from the tip of the needle (97%). More than 50% regional fat (around the target lesion) was the strongest factor associated with migration, seen in 21/140 (15%), compared to 10/150 (7%) with less than 50% local fat (P = 0.023). Global fatty breast was more loosely associated with migration, showing borderline significance (P = 0.06). Other factors did not correlate with clip migration, including lesion size, depth or location, pathology result, breast thickness or biopsy approach.
Conclusion
Although clip migration following breast MRI-guided biopsy is an uncommon event, it occurs more often when the target lesion is surrounded by fat, with the clip usually displaced away from the biopsy needle. This information could be valuable for pre-surgical localization and surgical planning.
B-line by Lung Ultrasound as a Predictor of Re-intubation in Mechanically Ventilated Patients with Heart Failure
Authors: Hyun Junho , Kim Ah-ram , Lee Sang-Eun , Kim Min-Seok 
Published: August 2023

Abstract
There have been few studies on predictors of weaning failure from mechanical ventilation (MV) in patients with heart failure (HF). We sought to investigate the predictive value of B-lines measured by lung ultrasound (LUS) on the risk of re-intubation after MV weaning and in-hospital outcomes. This was a single-center, prospective observational study that included HF patients who were on invasive MV. LUS was performed right before ventilator weaning. A positive exam for B-lines was defined as the observation of two or more regions that had three or more numbers of B-lines located bilaterally on the thorax. Early re-intubation with 72 hours after MV weaning was significantly higher in the positive B-line group (14.1%) than the negative B-line group (2.4%) (p=0.011). The rate of total re-intubation during admission (p=0.004), duration of intensive care unit stay (p=0.004), and hospital stay (p=0.010) were greater in the positive B-line group. The negative predictive value (NPV) of positive B-lines was 97.6% for the primary outcome. B-lines measured by LUS can predict the risk of re-intubation after MV weaning. Considering the high NPV of positive B-lines, it may help guide the decision of extubation in patients on invasive MV due to acute decompensated HF.
An inventory of medicinal and poisonous plants of the National Veterinary Research Institute Vom, Plateau State, Nigeria
Authors: Akpojosevbe Edirin James , Ishaku Leo Elisha , Akogwu Emmanuel Itodo , Tondo Bernard Kpensalen , Hong Joseph , Muhammad Zainab , Oyebade Kehinde Funmi , Makoshi Micah Shehu , Shok Blessing Zataat , Okpalaeke Emilia Ebere , Usman Joy Gararawa , Gotep Jurbe Gofwan , Kwaja Elisha Zailani , Barde Israel Joshua , Bitrus Yakubu , Muhammad Maryam 
Published: August 2023

Abstract
Traditional medicinal plants are still commonly used for primary healthcare in developing countries, and this study seeks to identify the types of medicinal plants present in our community and document the knowledge of poisonous plants. The study area was divided into four blocks, and the plants within each block were identified through a field survey using Android phones equipped with Google lens and GPS. Local and scientific names of the medicinal plants were identified using photographs, herbaria, and references. The study found a total of 98 medicinal plant species belonging to 41 plant families, with Fabaceae, Euphorbiaceae, and Lamiaceae families having the highest number of species. This study is significant for conserving traditional medicinal plants and adding to the inventory of medicinal plants in the area for conservation purposes. Furthermore, it is essential for public health and safety, as proper identification of medicinal plants is crucial to avoid poisoning.
Recycled Counterfeit Chips Detection for AMS and Digital ICs Using Low-Area, Self-Contained, and Secure LDO Odometers
Authors: Roy Sourav , Chen JinHong , Maghari Nima , Forte Domenic 
Published: August 2023

Abstract

Counterfeit electronics have widespread im-pacts on the many aspects of modern civilization thatdepend on integrated circuits (ICs) or chips. Among allof the counterfeit chips types, recycled and remarkedare the most prevalent. These are the chips that aretaken from discarded, obsolete electronics board andthen sold as new. As a result, they are aged and de-teriorated with short remaining lifespan and prone tofailure. Silicon odometers have been proposed to detectrecycled digital ICs, but few are applicable to analogand mixed signal (AMS) chips. Recently, an odometerthat can be integrated into a common AMS IP block,the low dropout regulator (LDO), was proposed. However, it has high area overhead, requires external mea-surements for classification, and has a security vulnera-bility. In this article, self-contained LDO odometers areproposed that overcomes these issues while still beingable to detect aging in AMS and digital chips. A calibra-tion feature is also introduced to compensate for processvariation. The area overhead of the analog and digitalversions are 8μm2 and 3.3μm2, respectively, which arean order of magnitude smaller than the prior state-of-the-art. A detection accuracy of 98.2% and 99.5% havebeen achieved for each which are comparable to existing odometers.
New strains of Trichoderma with potential for biocontrol and plant growth promotion improve early soybean growth and development
Authors: Galeano Rodrigo Mattos Silva , Ribeiro João Victor Souza , Silva Samanta Monção , Simas Ana Lorena de Oliveira , Guimarães Nelciele Cavalieri de Alencar , Masui Douglas Chodi , Corrêa Bianca Obes , Giannesi Giovana Cristina , de Lima Sebastião Ferreira , Brasil Marivaine Silva , Zanoelo Fabiana Fonseca 
Published: August 2023

Abstract

Aims
Bioformulations with Trichoderma strains offer cost-effective and sustainable options for integrated disease management and plant nutrition. Therefore, this study aimed selected new isolates of Trichoderma with antagonistic and plant growth promotion abilities, including the effect of inoculation of isolates on the early development of soybean seedlings.
Methods
Trichoderma isolated from the soybean rhizosphere were screenings assessed their antagonistic activity against three phytopathogens, as well as their capability for indole-3-acetic acid (IAA) synthesis and phosphate solubilization. Three promising isolates were further examined for their tolerance to various in vitro conditions and agrochemicals. Single and co-inoculation experiments to assess their effects on growth, chlorophyll, carotenoids, proteins, flavonoids, and phenolic compounds during early soybean development.
Results
T. viride GT-8, T. reesei GT-31, and T. longibrachiatum GT-32 demonstrated antagonism against phytopathogens. GT-31 and GT-32 exhibited higher IAA synthesis (175.8 ± 2.4 µg/mL and 119.6 ± 11.2 µg/mL, respectively), while GT-8 showed superior phosphate solubilization (28.56 ± 0.4 µg P/mL). All three fungi displayed robust growth under various conditions and agrochemical treatments. Trichoderma inoculation significantly enhanced shoot and root growth, with co-inoculation resulting in even higher dry shoot and root weights, increasing by 50.3% and 48.8%, respectively, compared to non-inoculated seedlings. Trichoderma-inoculated plants also exhibited elevated chlorophyll, carotenoids, flavonoids, and phenolic compounds.
Conclusion
Overall, these findings highlight the potential of these novel Trichoderma isolates for formulating bioformulations that can enhance plant growth and offer benefits in soybean crops, providing a sustainable strategy for agriculture.
Genetic Analysis of Exacerbated Healing Responses after Periodontal Therapy due to Type 2 Diabetes: Clinical and in vivo Studies
Authors: Nakagawa Keita , Watanabe Kazuki , Mizutani Koji , Takeda Kohei , Takemura Shu , Sakaniwa Eri , Mikami Risako , Kido Daisuke , Saito Natsumi , Kominato Hiromi , Hattori Atsuhiko , Iwata Takanori 
Published: August 2023

Abstract
Background
This study aims to investigate the mechanisms underlying the exacerbated healing response by diabetes after periodontal therapy.
Methods
Zucker diabetic fatty (ZDF) and lean (ZL) rats underwent experimental periodontitis by ligating the mandibular molars for one week. The gingiva at the ligated sites was harvested one day after ligature removal, and gene expression was comprehensively analyzed using RNA-Seq. In patients with and without type-2 diabetes (T2D), the corresponding gene expression was quantified in the gingiva of the shallow sulcus and residual periodontal pocket after non-surgical periodontal therapy.
Results
Ligation-induced bone resorption and its recovery after ligature removal were significantly impaired in the ZDF group than in the ZL group. The RNA-Seq analysis revealed 252 differentially expressed genes. Pathway analysis demonstrated an enrichment of downregulated genes involved in peroxisome proliferator-activated receptor (PPAR) signaling pathway. PPARα and PPARγ were decreased in mRNA level and immunohistochemistry in the ZDF group than in the ZL group. In clinical, less probing depth reduction and significantly downregulated expression of PPARα and PPARγ were detected in the residual periodontal pocket of the T2D group compared with those of the control group.
Conclusions
Downregulated PPAR subtypes expression may involve the impaired healing of periodontal tissues by diabetes.
Activated Carbon prepared from ridge gourd peels as a novel adsorbent for removal of cephalexin from wastewater
Authors: krishna gautham 
Published: August 2023

Abstract
Ride gourd peels were used to prepare activated carbon (RGAC) by zinc chloride activation. In order to remove Cephalexin (CFX) from aqueous solution, the RGAC was utilized as an adsorbent. CFX being an antibiotic pollutant which can cause hormonal changes in living organisms on long-term consumption, needs immediate attention in its removal specially from aquatic environment. It was discovered that RGAC could potentially remove CFX. The RGAC's highly porous structure and uneven surface were discovered by scanning electron microscopy. The excellent adsorption capacity of RGAC was aided by its large surface area − 945.857 m2/g and middling pore size − 1.7 nm. The maximal CFX adsorption capacity of RGAC was determined to be 37.56 mg/g. The highest connection between the theoretical and experimental data was found for the Langmuir isotherm at 25 oC (R2 = 0.9647), which suggests monolayer adsorption. The experimental findings are well-matched by the pseudo-second-order kinetics model. Fourier transform infrared analysis proved the existence of zinc comprising groups, C-H, C-O, C = O and C = C functional groups on the facade of RGAC. A negative surface charge was indicated by zeta potential analysis. The usage of RGAC as an adsorbent for CFX removal is investigated in this study which is first of its kind in this field.
Help-seeking behaviours and experiences for mental health symptoms related to the menstrual cycle: a UK-wide exploratory survey
Authors: Funnell Erin , Martin-Key Nayra A. , Spadaro Benedetta , Bahn Sabine 
Published: August 2023

Abstract
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) are menstrual cycle-related disorders characterised by psychological and physical symptoms which impact functioning. Little is known about avenues for help-seeking for these disorders. Therefore, we sought to examine help-seeking behaviors and experiences, and investigate differences between identified PMS and PMDD groups. An online survey was delivered and data from 530 participants were analysed. All participants endorsed at least one PMS symptom, with 97.17% experiencing functional impairment. Help was sought by 64.91% (online: 45.93%; formal: 11.34%; online and formal: 42.73%), with 78.49% perceiving their symptoms were not taken seriously when seeking formal help. Most sought help online to look up symptoms (85.57%) and treatment options (39.67%). The study revealed the high frequency of PMS symptoms and the impact on wellbeing, as well as the significant proportion of online help-seekers, emphasizing the need for high-quality, evidence-based online resources and improvement of formal care interactions.