bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the Role of Health Investments in Driving Economic Growth: Evidence from Rwanda
Authors: Jacques NGARUKIYE SEKANYANGE 
Published: February 2025

Abstract

Background
This study investigates the relationship between health investments and economic growth in Rwanda, analyzing the role of government and private health expenditures in driving economic development in Rwanda.
Methods
Using Full Modified Ordinary Least Squares (FM OLS) analysis, the research examines how factors such as health expenditure, household consumption, labor force participation, and life expectancy impact economic growth. Descriptive statistics and the Augmented Dickey-Fuller (ADF) Unit Root Test were first employed to assess key variables' stationarity, which indicated non-stationary data at original levels. The study then applied FM OLS regression analysis to explore direct effects.
Results
The results showed that health expenditure per capita had a positive impact on economic growth, with a coefficient of 0.60, suggesting that increased health spending directly boosts the economy. Household consumption expenditure also contributed significantly, with a coefficient of 0.49, highlighting the importance of consumption in driving economic activity. Additionally, labor force participation and life expectancy had positive coefficients of 0.17 each, indicating that a healthier, more engaged workforce fosters economic output. The model accounted for 99.37% of the variation in economic growth, demonstrating a robust fit, while the Durbin-Watson statistic confirmed the absence of significant autocorrelation.
Conclusion
The study concludes that health investments are crucial to Rwanda’s economic development. It recommends scaling up health investments, improving healthcare infrastructure, ensuring equitable healthcare access, and addressing income inequality. Moreover, policies aimed at increasing labor force participation and fostering economic diversification are advised to enhance growth. Public-private partnerships are also suggested to amplify the benefits of health investments.
SERS substrate based on COFs@Ag for rapid detection of pefloxacin
Authors: Chen Kun , Ma Chaoqun , Chen Guoqing , Yang Taiqun , Gao Hui , Li Lei , Hu Anqi , Cao Jun , Zheng Chenkai , Ma Longyao , Chen Zehao 
Published: February 2025

Abstract

The detection of pefloxacin in milk is of significant importance for food safety. Traditional methods for detecting pefloxacin often rely on techniques such as high-performance liquid chromatography (HPLC), which are complex and time-consuming. This article introduces a surface-enhanced Raman scattering (SERS) substrate based on a composite of covalent organic frameworks (COFs) and silver nanoparticles (AgNPs) for the rapid detection of pefloxacin in milk. After testing pefloxacin (PEF) in both water and milk, the detection limits were calculated to be 6.31 µg/L for water and 82 µg/L for milk, with correlation coefficients of 0.991 and 0.998, respectively. Furthermore, the average recovery rate of pefloxacin in milk ranged from 96.25–106.17%, with a relative standard deviation (RSD) of 4.32–8.88%. This work offers a simple and rapid method for detecting pefloxacin in milk.
Comparison of Streptococcus mutans adhesion to fixed orthodontic wires in different types of saliva under laboratory conditions
Authors: SheibaniNia Ahmad 
Published: February 2025

Abstract

Objectives: This study investigates the adhesion of Streptococcus mutans to fixed orthodontic wires in varying types of saliva under laboratory conditions, given the heightened microbial load and increased caries prevalence in patients with orthodontic appliances.
Methods and Materials: Stainless steel wires and nickel-titanium wires of the same dimensions were utilized, with six samples per group. After preparation and sterilization, the samples were immersed for two hours in artificial saliva solutions with either normal or acidic pH. Subsequently, the samples were incubated in a S. mutanssuspension. Following serial dilution and cultivation on BHI agar, the number of former colonies was counted. The results were analyzed using two-way ANOVA with a significance level at p ≤ 0.05.
Results: The adhesion rate of S. mutans to stainless steel archwires was significantly higher than that to nickel-titanium archwires in both acidic and normal saliva (p ≤ 0.05). Moreover, the adhesion rate to both archwires was lower in acidic saliva compared to normal saliva (p ≤ 0.05).
Conclusion: S. mutans exhibits a lower adhesion rate to nickel-titanium archwires compared to stainless steel archwires in both acidic and normal saliva.
Phosphorus-Doped NiFe Electrodes for Stable Alkaline Seawater Electrolysis at Industrial Current Densities: Facile Synthesis and Mechanistic Insights
Authors: Wang Wei , Ren Zhibo , Liu Peng , Zhang Chang , Wang Tao , Wang Fan , Yan Xupeng , Guo Weiqi , Wu Zhan , Wang Jinyi 
Published: February 2025

Abstract

Direct seawater electrolysis offers a promising route for sustainable hydrogen production, particularly in offshore applications, yet challenges such as high overpotentials at industrial current densities and chloride-induced corrosion hinder its scalability. Herein, we report a phosphorus-doped NiFe electrode (P-NiFe-NF) synthesized via a scalable electrodeposition and vapor-phase deposition approach. The optimized P-NiFe-NF electrode achieves a low oxygen evolution reaction (OER) overpotential of 282 mV at 400 mA/cm² in simulated seawater and demonstrates exceptional stability for 175 hours under continuous operation at 400 mA/cm². The incorporation of phosphorus facilitates the in situ formation of a phosphate-rich surface layer, effectively repelling chloride ions and suppressing competitive chlorine evolution. Combined with the synergistic catalytic activity of Ni and Fe, this design enables high efficiency and durability at industrial-relevant current densities. The simplicity of the fabrication process and robust performance highlight its potential for large-scale hydrogen production from seawater.
Breaking out of the silo: collaborative approaches to implementing blue-green infrastructure in urban areas
Authors: Hohmann Claudia , Bieker Susanne , Truffer Bernhard 
Published: February 2025

ABSTRACT

Blue-green infrastructure (BGI) represents a subtype of nature-based solutions that leverages the collective benefits of urban green spaces and urban water management for the purpose of climate change adaptation. The success of BGI as an alternative or as a complement to the current ‘gray’ urban infrastructure is, however, hampered by existing urban planning structures. Given the numerous advantages that BGI can offer, it is essential to integrate different sectors and policy domains in order to ensure its effective implementation. This represents a novel challenge in urban planning, as the responsibility for providing different parts of urban infrastructure is traditionally split across specialized departments. In order to accelerate the successful establishment of BGI through stakeholder collaboration, the infrastructure transition canvas is employed to identify and structure coordination gaps between key actors, with the objective of developing new mechanisms of collaboration. This results in four principal coordination tasks for BGI projects: (i) coordination for value creation, (ii) coordination of stakeholders with formal decision-making power, (iii) engaging stakeholders who have no formal mandate, and (iv) intermediation. In conclusion, the paper presents a synthesis of the conditions required for stakeholder collaboration that contribute to redistributing the roles and responsibilities to facilitate successful BGI implementation.
Estradiol Promotes Endometriosis Progression Via the ERβ/QKI /circSMAD2 Axis
Authors: Peng Yuan , Xiong Wenqian , He Haitang , Liu Hengwei , Fu Tian , Long Xuefeng , Li Xiaoou , Dai Xin , Xu Ying , Zhang Ling , Liu Yi 
Published: February 2025

Aims:
The present study aimed to examine the roles of circRNA-circSMAD2 and its
regulatory mechanisms in endometriosis (EMs).

Background:
Evidence has confirmed that circRNAs play multiple roles in regulating the occurrence
and development of EMs, but the regulatory mechanisms of circRNAs in EMs remain
largely unknown.

Objective:
The roles and regulatory mechanisms of circSMAD2 in EMs.

Method:
Eutopic and ectopic endometrium of ovarian EMs as well as normal endometrial
tissues, were used to extract circRNA, mRNA, and total proteins. The human endometrial stromal
cell lines (ThESCs) and endometrial stromal cells (ESCs) were stimulated with different
concentrations or times of 17β-estradiol (E2). The mouse model of EMs was established by implanting
uterine horns onto the peritoneum wall using a suture.

Result:
Compared with normal tissues, the expression of circSMAD2 was significantly decreased
in eutopic and ectopic endometrial tissues. Furthermore, the expression of circSMAD2
was downregulated by E2 in a dose- and time-dependent manner in ThESCs and ESCs. Overexpression
of circSMAD2 inhibited the invasion and migration of ThESCs, while knockdown of
circSMAD2 exerted the opposite effect. The RNA binding protein quaking (QKI), which is involved
in circRNA formation, was lower in eutopic and ectopic endometrial tissues compared to
normal tissues.

conclusion:
The E2/ERβ/QKI/circSMAD2 pathway was involved in cellular migration and invasion in EMs

Conclusion:
Moreover, E2 suppressed the expression of circSMAD2 by inhibiting the expression
of QKI. Additionally, E2 enabled the expression of estrogen receptor beta (ERβ) to inhibit
the expression of QKI and circSMAD2 in vitro and in vivo.

Conclusion:
The E2/ERβ/QKI/circSMAD2 pathway was involved in cellular migration and
invasion in EMs.
Bibliometric and Visualization Analysis of Research on Exosomes as Drug Delivery Systems (2008-2023)
Authors: Xiang Wei , Shang Qisong , Zhu Zhoujun , Wu Yuanyuan , Song Xinghua 
Published: February 2025

Objective:
Exosomes are unique bio-nanomaterials possessing significant value and potential
for drug delivery systems. However, to date, no bibliometric studies in this field have been reported.
Our aim is to explore the research hotspots and trends of exosome drug-carrying systems
across various medical fields through bibliometric analyses.

Methods:
Articles and reviews related to “exosome” and “drug delivery” are retrieved from the Web
of Science Core Collection. VOSviewer, CiteSpace, Scimago Graphica, and Origin 2021 are employed
for bibliometric analyses.

Results:
A total of 771 articles from 60 countries, such as China and the United States, are included.
The number of papers concerning exosomal drug delivery systems has been increasing yearly. The
main research institutions are the Chinese Academy of Sciences, Shanghai Jiao Tong University,
Huazhong University of Science and Technology, Fudan University, and Sichuan University. The
Journal of Controlled Release is the most prevalent and frequently cited journal in this field. These
papers are authored by 247 individuals, with Ando, Hidenori having the highest number of publications
and Alvarez-Erviti L receiving the most citations. “Extracellular vesicles”, “drug delivery”, “in
vitro”, “nanoparticles”, “cells”, “delivery”, and “mesenchymal stem cells” are the principal keywords
for this hotspot.

Conclusion:
This pioneering bibliometric study offers a comprehensive overview of the research
trends and advancements in exosomal drug delivery systems in medicine over the past fifteen years.
The Influence of Service Quality on Customer Satisfaction: An Empirical Study in the Fast-Food Industry
Authors: Md Johan Nur Jihan , Hamdan Nur Hazirah , Abd Rashid Suliza , Mustapha Nur Diyana 
Published: February 2025

Service quality (SERVQUAL) is crucial in knowing whether customers receive the level of services they expect and whether such services affect their satisfaction. This study examines the relationship between customer satisfaction and SERVQUAL dimensions of the A&W outlet at Aeon Bandaraya Melaka. 300 respondents were involved in this study, and the data were collected from the distribution of questionnaires. It was found that there was a significant relationship between customer satisfaction and SERVQUAL dimensions of A&W outlet Aeon Bandaraya Melaka, and SERVQUAL remains a critical factor for A&W. Thus, this study suggests that future research could be carried out in diverse cultural or regional settings to evaluate the relationship between service quality and customer satisfaction across international marketplaces. This will assist the other fast-food industry to overcome the SERVQUAL issues and maintain the sustainability of the fast-food economy.
The Effect of Enterprise Risk Management Implementation on Non-Financial Performance in Jordan Manufacturing Firms: A Review
Authors: Abdaljabar Wafa Mohammad , Zakuan Norhayati , Mat Saman Muhamad Zameri , Setapa Mariam 
Published: February 2025

Previous business crises have highlighted the shortcomings in the methodologies employed for risk management within organizations. In response to these problems, organizational risk management has gained importance recently for the oversight of corporate risk. Unlike solo-based risk management, Enterprise Risk Management (ERM) analyses the organization's whole risk exposure in an integrated and complete manner. The execution of such an integrated approach is essential for all organizations of size and types. Therefore, this study aims to investigate how the COSO ERM framework is considered a crucial framework that provides precise direction and guidance in enterprise risk management among manufacturing enterprises in Jordan and its impact on non-financial performance to enable organizations to mitigate risks and losses and exploit the opportunities.? Furthermore, it highlights the prominent role of risk governance including boards of directors, risk committees, chief risk officers, and IT systems as moderators of this relation.
PENGEMBANGAN MEDIA VIDEO PEMBELAJARAN BERBASIS PENDEKATAN STEM UNTUK MENINGKATKAN PENGUASAAN KONSEP FISIKA SISWA MATERI SUHU DAN KALOR DI SMA NEGERI 4 KISARAN
Authors: Anjani Astri , Wulandari Dewi 
Published: February 2025

Indonesia telah memasuki era teknologi pendidikan di mana media dapat mendukung aktivitas pembelajaran. Salah satu pendekatan pembelajaran yang dapat digunakan dalam media adalah pendidikan STEM. Tujuan penelitian ini adalah untuk menentukan validitas, kepraktisan, dan efektivitas pengembangan video pembelajaran Fisika berbasis STEM pada materi suhu dan kalor untuk meningkatkan penguasaan konsep siswa. Penelitian RnD ini menggunakan model pengembangan 4D yang diperkenalkan oleh Thiagarajan. Media dikembangkan melalui 4 tahap: define untuk menentukan hasil belajar dan kebutuhan siswa, design untuk merancang prototipe media, development untuk menentukan validitas dan kepraktisan media, dan dissemination. Hasil validitas media adalah 88,5% dalam kategori sangat layak dan valid, uji kepraktisan pengguna sebesar 90,6% dalam kategori sangat praktis, dan nilai N-gain dari pre-test dan post-test sebesar 0,31 menunjukkan peningkatan rata-rata penguasaan konsep pada kategori sedang. Kata Kunci: RnD, Video pembelajaran, STEM, Penguasaan konsep.
PENGARUH MODEL DISCOVERY LEARNING TERHADAP HASIL BELAJAR SISWA PADA MATERI GELOMBANG BUNYI
Authors: Manurung Angelina , Tampubolon Togi 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh model discovery learning terhadap hasil belajar siswa pada materi gelombang bunyi. Populasi dalam penelitian ini adalah seluruh siswa kelas XI SMA Negeri 1 Silaen T.P 2023/2024 dan sampel diambil sebanyak 2 kelas secara random. Dalam penelitian yang digunakan adalah Two Group Pretes-PostesDesign. Instrumen penelitian menggunakan tes hasil belajar berbentuk pilihan berganda sebanyak 25 soal dan aktivitas siswa dengan lembar observasi. Berdasarkan hasil penelitian diperoleh nilai rata-rata pretes kelas eksperimen 30,93 dan hasil pretes kelas kontrol 28,8. Setelah diberi perlakuan model discovery learning terhadap kelas eksperimen diperoleh nilai rata-rata postes 70,8. Sedangkan kelas kontrol dengan pembelajaran konvensional diperoleh nilai rata-rata pretes 60,13. Analisis data dilakukan dengan uji t pada taraf signifikansi α = 0,05, dinyatakan bahwa ada perbedaan hasil belajar siswa setelah diberikan perlakuan model discovery learning terhadap hasil belajar siswa sehingga model discovery learning berpengaruh terhadap hasil belajar siswa pada materi gelombang bunyi Kata Kunci: Discovery learning, hasil belajar, gelombang bunyi
EFEKTIVITAS BAHAN AJAR DIGITAL UNTUK MATA KULIAH TEKNOLOGI INFORMASI DAN LITERASI DATA DI JURUSAN FISIKA
Authors: Ramadhani Irham , Purwanto Purwanto , Simanjuntak Yanthy Leonita Perdana 
Published: February 2025

Penelitian ini bertujuan untuk menguji efektivitas bahan ajar mata kuliah Teknologi Informasi dan Literasi Data di Jurusan Fisika Universitas Negeri Medan. Penelitian menggunakan pendekatan kualitatif dengan instrumen berupa angket yang disebarkan kepada mahasiswa jurusan fisika. Angket tersebut dirancang untuk mengukur respons mahasiswa terhadap penggunaan bahan ajar serta mengevaluasi efektivitasnya dalam mendukung proses pembelajaran. Hasil penelitian menunjukkan bahwa bahan ajar mata kuliah TILDA efektif digunakan dalam perkuliahan, dengan hasil evaluasi berada dalam kategori baik. Temuan ini mengindikasikan bahwa bahan ajar yang dikembangkan mampu memenuhi kebutuhan pembelajaran mahasiswa, baik dari segi konten maupun penyampaian materi. Untuk pengembangan lebih lanjut, disarankan agar bahan ajar ini terus disempurnakan guna meningkatkan efektivitas pembelajaran dan mendukung pencapaian kompetensi mahasiswa secara optimal. Kata Kunci: Bahan Ajar, Efektivitas, Angket.
PENGARUH MODEL PEMBELAJARAN BERBASIS MASALAH BERBANTUAN SIMULASI PHET TERHADAP KEMAMPUAN PEMECAHAN MASALAH SISWA PADA MATERI GELOMBANG MEKANIK DI SMA NEGERI 1 PERCUT SEI TUAN
Authors: Sari Windi Laila , Lubis Rajo Hasim 
Published: February 2025

Masalah yang menyebabkan rendahnya hasil belajar fisika disebabkan oleh kurangnya keterampilan pemecahan masalah siswa. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran berbasis masalah yang dibantu dengan simulasi PhET terhadap keterampilan pemecahan masalah pada materi gelombang mekanik. Jenis penelitian yang digunakan adalah kuasi eksperimen dengan desain penelitian pretest dan posttest control group design, dengan populasi seluruh siswa kelas XI SMA Negeri 1 Percut Sei Tuan. Sampel diambil menggunakan simple random sampling, yaitu kelas XI-3 yang menggunakan model pembelajaran berbasis masalah yang dibantu dengan simulasi PhET dan kelas XI-5 yang belajar menggunakan pembelajaran konvensional. Instrumen yang digunakan adalah tes essai dengan jumlah 8 soal yang telah tervalidasi. Teknik analisis data yang digunakan adalah uji hipotesis (uji t), yang sebelumnya dilakukan uji normalitas dan uji homogenitas. Berdasarkan uji hipotesis, dapat disimpulkan bahwa ada pengaruh model pembelajaran berbasis masalah yang dibantu simulasi PhET terhadap keterampilan pemecahan masalah siswa kelas XI SMA Negeri 1 Percut Sei Tuan T.P 2022/2023. Kata kunci: Model Pembelajaran Berbasis Masalah, Simulasi PhET, KPM
Interaksi Hadis dan Budaya: Interpretasi Ali Mustafa Yaqub dalam Kitab Al-Turuq Al-Sahihah Fi Fahm Al-Sunnah Al-Nabawiyah
Authors: Khalilurrahman As'ad , Ichwayudi Budi , Shobri Alwi , Akbar Riko 
Published: February 2025

The source of religious teachings is the Qur'an and hadith (sayings and actions of Prophet Muhammad). The birth of both is closely related to the culture and customs of the society at that time. The Prophet used culture as a medium to convey his message. The actions of the Prophet served as an example for humanity, especially Muslims, in the world. These behaviors and traits are referred to as the "sunnah." One example of the Prophet's habits is wearing the imamah or turban, letting his hair grow long, and many other aspects related to the Prophet's life. As devout followers, it is important to practice everything the Prophet did as a form of reverence for him. However, the challenge arises because every place has different cultures and customs. This becomes an issue when the Prophet's habits, as depicted in the hadiths, are not followed due to reasons not related to religious matters. Consequently, practices that are not considered acts of worship (ibadah) may be abandoned according to the local culture and traditions.
Abstrak
Sumber ajaran agama adalah al-Qur’an dan hadis. Lahirnya keduanya tidak lepas dari budaya dan kebiasaan masyarakat pada masa itu. Nabi menggunakan budaya sebagai media dalam menyampaikan risalahnya. Tindakan yang dilakukan Nabi adalah suri tauladan atau contoh untuk umat manusia khususnya muslim didunia. Prilaku dan sifat itulah disebut dengan sunnah. Salah satu contoh kebiasaan Nabi adalah menggunakan imamah atau sorban, membiarkan rambutnya panjang dan banyak lagi hal-hal yang berkenaan dengan kehidupan Nabi. Sebagai umat yang taat beragama perlulah utuk mengamalkan semua yang dilakukan Nab dalam bentuk rasa cita kepada Nabi. namun masalahnya adalah setiap tempat mempunyai budaya dan istiadat yang berbeda-beda. Hal ini menjadi masalah ketika kebiasaan Nabi yang tergambar dalam kitab-kitab hadis tidak diamalkan dengan alasan bukan perkara agama. Sehingga amalan yang ranahnya bukan ibdah boleh ditinggal sesuai budaya, tradisi masyarakat setempat.
Konsep Al-Mass dalam Al-Qur'an (Suatu Kajian Tafsir Maudu’i)
Authors: Asirah Siti , Abubakar Achmad , Hidayatulah Galib Ahmad Syarif 
Published: February 2025

Penelitian ini merupakan penelitian terhadap konsep al-mass dalam Al-Qur’an, untuk menyelami ayat-ayat Al-Qur’an yang berkaitan dengan makna al-Mass­ sebagai landasan dalam memahami Al-Qur’an, sekaligus mengimplementasikan petunjuknya dalam memandu manusia kepada jalan yang diridhai Allah swt. Penelitian ini bertujuan untuk memahami hakikat, wujud serta urgensi al-mass dalam Al-Qur'an. Penelitian yang dilakukan merupakan penelitian pustaka dengan pendekatan deskriptif. Pendekatan yang diterapkan adalah ilmu tafsir dan teologis. Penelitian ini juga mengadopsi pola tafsir Mauḍū’i dalam mengolah data yang terkumpul. Hasil dari penelitian ini adalah pertama, hakekat al-mass dalam Al-Qur’an digunakan untuk menunjuk adanya hubungan dengan sesuatu, baik terkait fisik maupun non fisik, baik yang menyenangkan maupun yang menyulitkan. Meskipun pada umumnya digunakan untuk menunjuk kepada hal-hal yang menyulitkan, baik jasmani maupun rohani. Kedua, wujud al-mass dalam Al-Qur’an yaitu penimpaan dalam bentuk al-ba’sā’ dan al-darrā’. menggambarkan respon manusia terhadap penderitaan. Ketika terbebas, manusia cenderung lupa dan menyatakan kebebasannya sebagai hasil kepintarannya. Sebaliknya, saat ditimpa penderitaan, manusia berdoa dan berserah sepenuhnya kepada Allah. Ketiga, urgensi al-mass sebagai pengajaran bagi umat manusia agar terhindar dari kesulitan, penderitaan dan siksaan baik dari segi duniawi maupun ukhrawi. Implikasi dari penelitian ini dapat menjadi renungan bersama terkait gambaran perilaku manusia saat menghadapi penderitaan, dengan harapan menghindari siksaan sebagaimana diceritakan dalam Al-Qur'an pada masa lalu. Kemudian penelitian ini penulis juga berharap dapat menambah wawasan pembaca terkait objek kajian yang terkandung dalam al-Qur’an.