bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence rate and distinctive characteristics of first episode psychosis during the COVID-19 pandemic: a multicenter observational study
Authors: Casanovas Francesc , Trabsa Amira , Bergé Daniel , Sánchez-Gistau Vanessa , Moreno Irene , Sanchez Julia , Montalvo Itziar , Tost Meritxell , Labad Javier , Pérez-Solà Victor , Mané Anna 
Published: December 2022

AbstractThe COVID-19 pandemic has affected the mental health of people around the world. However, its impact on first-episode psychosis (FEP) remains unclear. The aim of this study was to determine the incidence rate (IR) and the clinical and sociodemographic characteristics of patients who developed FEP during the nine-month period following the COVID-19 outbreak in Spain and to compare these data to the corresponding period in the previous year. We included all patients (n = 220) treated for the first time during these two time periods at three FEP programs in Spain. The IR was 0.42/100,000 person-years during the pandemic vs. 0.54/100,000 in the prior year (p = 0.057). Compared to prior year, women accounted for a significantly higher proportion of FEP patients (46.3% vs. 28%; p = 0.005) during the COVID-19 period. This association was significant on the logistic regression analysis (odds ratio, female: 2.12 [confidence interval 1.17–3.82]; p = 0.014). These data reveal a non-significant trend towards a lower incidence of FEP during the pandemic period. Female sex was associated with a greater risk of developing FEP during the pandemic period, perhaps due to differences between males and females in the susceptibility and expression of psychosis. The findings of this study contribute to a better understanding of stress-related disorders.
Field study on the severity of photovoltaic potential induced degradation
Authors: Badran Ghadeer , Dhimish Mahmoud 
Published: December 2022

AbstractPhotovoltaic (PV) systems can be affected by different types of defects, faults, and mismatching conditions. A severe problem in PV systems has arisen in the last couple of years, known as potential-induced degradation (PID). During the early installation stage of the PV system, the PID may not be noticed because it appears over time (months or years). As time passes, it becomes more apparent since the output power may drop dramatically. We studied PV modules over the course of three years that were affected by PID. An electroluminescent and thermal imaging technique helped discover the PID. PID appeared in PV modules after being in different fields for 4–8 months, resulting in a 27–39% drop in power. An anti-PID box was fitted during the second year of the PV operation to recover the PID. Accordingly, it has stabilized the power degradation, but it could not restore the performance of the affected PID modules as compared with healthy/non-PID modules.
Anastellin impacts on the processing of extracellular matrix fibronectin and stimulates release of cytokines from coronary artery smooth muscle cells
Authors: He Jianfei , Steffen Jonas Hyld , Thulstrup Peter Waaben , Pedersen Jannik Nedergaard , Sauerland Max B. , Otzen Daniel E. , Hawkins Clare L. , Gourdon Pontus , Davies Michael J. , Hägglund Per 
Published: December 2022

AbstractAnastellin, a recombinant protein fragment from the first type III module of fibronectin, mimics a partially unfolded intermediate implicated in the assembly of fibronectin fibrils. Anastellin influences the structure of fibronectin and initiates in vitro fibrillation, yielding “superfibronectin”, a polymer with enhanced cell-adhesive properties. This ability is absent in an anastellin double mutant, L37AY40A. Here we demonstrate that both wild-type and L37AY40A anastellin affect fibronectin processing within the extracellular matrix (ECM) of smooth muscle cells. Fibronectin fibrils are diminished in the ECM from cells treated with anastellin, but are partially rescued by supplementation with plasma fibronectin in cell media. Proteomic analyses reveal that anastellin also impacts on the processing of other ECM proteins, with increased collagen and decreased laminin detected in media from cells exposed to wild-type anastellin. Moreover, both anastellin forms stimulate release of inflammatory cytokines, including interleukin 6. At the molecular level, L37AY40A does not exhibit major perturbations of structural features relative to wild-type anastellin, though the mutant showed differences in heparin binding characteristics. These findings indicate that wild-type and L37AY40A anastellin share similar molecular features but elicit slightly different, but partially overlapping, responses in smooth muscle cells resulting in altered secretion of cytokines and proteins involved in ECM processing.
Analysis and design of terahertz reflectarrays based on graphene cell clusters
Authors: Hosseini Parinaz , Oraizi Homayoon 
Published: December 2022

AbstractIn this paper, the graphene cell-cluster is introduced, which is composed of an array of identical unit-cells placed in a geometrical configuration. Such graphene cell-clusters are then used for the realization of a reflectarray. To the best of our knowledge, identical unit-cells in a particular geometrical configuration have already been introduced, but the analytical formulas for this model have not been investigated so far. In this paper, the Fourier-optics and aperture field estimation methods are applied to investigate the effect of cell-cluster dimensions on the generation of specified far-field radiation patterns. Implementing cell-clusters in graphene reflectarrays and similar structures, and also applying the proposed formulas, lead to the simplicity of configuration and enhancing the design accuracy. First, the effect of cell-cluster dimensions on the reflectarray radiation pattern is investigated. Then, a reflectarray composed of graphene cell-clusters is designed. A new configuration of graphene unit-cell composed of two graphene layers is proposed, where a middle layer of metallic patch is inserted. In the common graphene unit-cells, the rate of amplitude variations is quite high and greatly depends on the variation of phase in the proposed unit-cell. However, the amplitude variation is quite smaller than the phase variations.
Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development
Authors: Bordet Guillaume , Karpova Iaroslava , Tulin Alexei V. 
Published: December 2022

AbstractThe transcriptome is subject to rapid and massive changes during the transition between developmental stages. These changes require tight control to avoid the undesired reactivation of gene expression that is only important for previous developmental stages and, if unchecked during transition between developmental stages, could lead to anarchic proliferation and formation of malignant tumors. In this context, the involvement of chromatin factors is important since they can directly regulate the expression of multiple genes at the same time. Poly(ADP-ribose) enzymes, involved in several processes from DNA repair to transcription regulation, might play a role in this regulation. Here, we report that PARP-1 and PARG cooperate to temporally regulate the gene expression profile during the larval/pupa transition. PARP-1 and PARG are both essential in repressing the expression of genes coding for digestive enzymes and larval cuticle proteins, while PARG positively regulate the expression of defense response genes. These results suggest a cooperative coordination between PARP-1 and PARG that specifically maintains the integrity of expression profile between developmental stages.
Task-evoked pupillary responses track precision-weighted prediction errors and learning rate during interceptive visuomotor actions
Authors: Harris D. J. , Arthur T. , Vine S. J. , Liu J. , Abd Rahman H. R. , Han F. , Wilson M. R. 
Published: December 2022

AbstractIn this study, we examined the relationship between physiological encoding of surprise and the learning of anticipatory eye movements. Active inference portrays perception and action as interconnected inference processes, driven by the imperative to minimise the surprise of sensory observations. To examine this characterisation of oculomotor learning during a hand–eye coordination task, we tested whether anticipatory eye movements were updated in accordance with Bayesian principles and whether trial-by-trial learning rates tracked pupil dilation as a marker of ‘surprise’. Forty-four participants completed an interception task in immersive virtual reality that required them to hit bouncing balls that had either expected or unexpected bounce profiles. We recorded anticipatory eye movements known to index participants’ beliefs about likely ball bounce trajectories. By fitting a hierarchical Bayesian inference model to the trial-wise trajectories of these predictive eye movements, we were able to estimate each individual’s expectations about bounce trajectories, rates of belief updating, and precision-weighted prediction errors. We found that the task-evoked pupil response tracked prediction errors and learning rates but not beliefs about ball bounciness or environmental volatility. These findings are partially consistent with active inference accounts and shed light on how encoding of surprise may shape the control of action.
Bacterial infections epidemiology and factors associated with multidrug resistance in the northern region of Ghana
Authors: Gnimatin Jean-Pierre , Weyori Enoch Weikem , Agossou Shimea M. , Adokiya Martin Nyaaba 
Published: December 2022

AbstractBacterial infections caused by multidrug resistant organisms are a major global threat. There is still a knowledge gap on this situation in the Northern Region of Ghana. This study determined the prevalence and resistance profile of bacterial infections. It also identified factors associated with multidrug resistance in the study area. This was a retrospective cross-sectional design and it analyzed data from the samples received at the Tamale Zonal Public Health Reference Laboratory from June 2018 to May 2022. The data were analyzed using the R software version 4.2.0. Univariate and multivariable binary logistic regression analyses were used to determine the factors associated with multidrug resistance. The samples included all specimen types possible. The specimens were collected for the purpose of clinical bacteriology diagnostics. Overall a total of 1222 isolates were obtained. The three (3) main bacteria responsible for infections were: Klebsiella spp. (27%), Moraxella spp. (22%), Escherichia spp. (16%). High resistance levels were found against the tested antibiotics and about 41.60% of the bacterial strains isolated were multidrug resistant. Hospitalization was associated with multidrug resistance in univariate (COR 1.96; 95% CI 1.43–2.71; P-value < 0.001) and multivariable analyses (AOR 1.78; 95% CI 1.28–2.49; P-value < 0.001). There is the need for further research on the molecular epidemiology of antibiotic resistance genes in the study area to effectively control the spread of multidrug resistant pathogens. In addition, efforts to build the capacity of health professionals on infection prevention and control as well as diagnostic and antimicrobial stewardship needs urgent attention.
Synergies of fuel cell system thermal management and cryogenic hydrogen exergy utilization
Authors: Lenger Magnus , Heinke Steffen , Tegethoff Wilhelm , Köhler Jürgen 
Published: December 2022

AbstractLow-temperature polymer electrolyte fuel cell systems (FCSs) need to reject large amounts of low temperature heat. Often a mobile FCS’s cooling capacity limits the FCS power output. Cryogenic hydrogen is typically utilized as a direct heat sink using heat exchangers (HXs), even though HXs destroy most hydrogen exergy. This paper investigates synergies between FCS thermal management and cryogenic hydrogen exergy utilization in terms of their benchmark performance: the FCS coolant circuit supplies heat at coolant temperature level to a so named reversible cryogenic exergy utilization system (rCEUS) comprised of thermodynamically ideal heat engine processes. The rCEUS converts this heat partly to electrical energy (the value of which equals the hydrogen exergy) and rejects remaining heat to hydrogen to heat it to coolant temperature. The rCEUS output power is used to support the FCS, so the FCS rejects less heat and a significant fraction of this heat is utilized by the rCEUS. As a result, significantly less heat has to be transferred to ambient and the fuel demand decreases. In this paper, three hydrogen storage options are compared: liquid hydrogen, subcooled liquid hydrogen and cryo-compressed hydrogen. Different para- and orthohydrogen compositions are evaluated. For typical FCS operating points, rejected FCS heat to ambient is reducible by 40–67%. FCS power demand is reducible by 14–31%. FCS rejected heat to ambient reduction is 4.5–8 times larger than that of conventional HXs. Calculations are based on hydrogen’s lower heating value.
Sex and menopause impact 31P-Magnetic Resonance Spectroscopy brain mitochondrial function in association with 11C-PiB PET amyloid-beta load
Authors: Jett Steven , Dyke Jonathan P. , Andy Caroline , Schelbaum Eva , Jang Grace , Boneu Yepez Camila , Pahlajani Silky , Diaz Ivan , Diaz Brinton Roberta , Mosconi Lisa 
Published: December 2022

AbstractIncreasing evidence implicates sex and endocrine aging effects on brain bioenergetic aging in the greater lifetime risk of Alzheimer’s disease (AD) in women. We conducted 31Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) to assess the impact of sex and menopause on brain high-energy phosphates [adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi)] and membrane phospholipids [phosphomonoesters/phosphodiesters (PME/PDE)] in 216 midlife cognitively normal individuals at risk for AD, 80% female. Ninety-seven participants completed amyloid-beta (Aβ) 11C-PiB PET. Women exhibited higher ATP utilization than men in AD-vulnerable frontal, posterior cingulate, fusiform, medial and lateral temporal regions (p < 0.001). This profile was evident in frontal cortex at the pre-menopausal and peri-menopausal stage and extended to the other regions at the post-menopausal stage (p = 0.001). Results were significant after multi-variable adjustment for age, APOE-4 status, midlife health indicators, history of hysterectomy/oophorectomy, use of menopause hormonal therapy, and total intracranial volume. While associations between ATP/PCr and Aβ load were not significant, individuals with the highest Aβ load were post-menopausal and peri-menopausal women with ATP/PCr ratios in the higher end of the distribution. No differences in Pi/PCr, Pi/ATP or PME/PDE were detected. Outcomes are consistent with dynamic bioenergetic brain adaptations that are associated with female sex and endocrine aging.
Transposed-word effects in speeded grammatical decisions to sequences of spoken words
Authors: Dufour Sophie , Mirault Jonathan , Grainger Jonathan 
Published: December 2022

AbstractWe used the grammatical decision task (a speeded version of the grammaticality judgment task) with auditorily presented sequences of five words that could either form a grammatically correct sentence or an ungrammatical sequence. The critical ungrammatical sequences were either formed by transposing two adjacent words in a correct sentence (transposed-word sequences: e.g., “The black was dog big”) or were matched ungrammatical sequences that could not be resolved into a correct sentence by transposing any two words (control sequences: e.g., “The black was dog slowly”). These were intermixed with an equal number of correct sentences for the purpose of the grammatical decision task. Transposed-word sequences were harder to reject as being ungrammatical (longer response times and more errors) relative to the ungrammatical control sequences, hence attesting for the first time that transposed-word effects can be observed in the spoken language version of the grammatical decision task. Given the relatively unambiguous nature of the speech input in terms of word order, we interpret these transposed-word effects as reflecting the constraints imposed by syntax when processing a sequence of spoken words in order to make a speeded grammatical decision.
High-speed metamagnetic switching of FeRh through Joule heating
Authors: Blumenschein Nicholas A. , Stephen Gregory M. , Cress Cory D. , LaGasse Samuel W. , Hanbicki Aubrey T. , Bennett Steven P. , Friedman Adam L. 
Published: December 2022

AbstractDue to its proximity to room temperature and demonstrated high degree of temperature tunability, FeRh’s metamagnetic ordering transition is attractive for novel high-performance computing devices seeking to use magnetism as the state variable. We demonstrate electrical control of the antiferromagnetic-to-ferromagnetic transition via Joule heating in FeRh wires. The magnetic transition of FeRh is accompanied by a change in resistivity, which can be probed electrically and allows for integration into switching devices. Finite element simulations based on abrupt state transition within each domain result in a globally smooth transition that agrees with the experimental findings and provides insight into the thermodynamics involved. We measure a 150 K decrease in transition temperature with currents up to 60 mA, limited only by the dimensions of the device. The sizeable shift in transition temperature scales with current density and wire length, suggesting the absolute resistance and heat dissipation of the substrate are also important. The FeRh phase change is evaluated by pulsed I-V using a variety of bias conditions. We demonstrate high speed (~ ns) memristor-like behavior and report device performance parameters such as switching speed and power consumption that compare favorably with state-of-the-art phase change memristive technologies.
A preliminary study of further attempt at the development, testing and application of an independent primary screening stool card
Authors: Cai Huimin , Chen Hongliang , Gao Yang , Huang Qianqian , Lv Chengqian , Cang Xueyu , Qi Jihan , Luo Kunpeng , Jin Shizhu 
Published: December 2022

AbstractStool characteristics are of great value to assess diseases, but patients knew little. E-learning applied in health popularization and patient education is booming. In China, WeChat applets has advantages of abundant users, convenient access and low cost, which may be a great media in patient education on stool. This preliminary study aims to develop and evaluate a stool card WeChat applet. We collected stools images during 2020 to 2022 in the Department of Gastroenterology and Hepatology in the Second Affiliated Hospital of Harbin Medical University, constructed a stool card applet named the Doctor Friend Primary Screening Stool Card (DFPSSC) and evaluated it. Eligible participants were divided into the applet, traditional paper media and control group. We implement a series of tests to evaluate the effectiveness. 20 clinicians and participants using the DFPSSC completed a questionnaire to evaluate the usability. We developed the DFPSSC for an E-learning approach. Of 108 volunteers, 97 completed the DFPSSC learning. No significant pretest differences were found among the three groups (P = 0.303). Applet group had significantly higher posttest scores than pretest scores in intervention (P < 0.001, d = 1.68) and simulation (P = 0.006) test, and it had higher scores than other two group (P < 0.001). 63% participants and 59% clinicians strongly agree or agree to the usability of DFSSC. This preliminary study verified that the DFPSSC can effectively improve participants’ knowledge of feces, making it an effective clinical tool for patient education and the avoidance of treatment delay.
Three mitochondrial lineages and no Atlantic-Mediterranean barrier for the bogue Boops boops across its widespread distribution
Authors: Cunha Regina L. , Faleh Abderraouf Ben , Francisco Sara , Šanda Radek , Vukić Jasna , Corona Luana , Dia Mamadou , Glavičić Igor , Kassar Abderrahmane , Castilho Rita , Robalo Joana I. 
Published: December 2022

AbstractMarine species exhibiting wide distributional ranges are frequently subdivided into discrete genetic units over limited spatial scales. This is often due to specific life-history traits or oceanographic barriers that prevent gene flow. Fine-scale sampling studies revealed distinct phylogeographic patterns in the northeastern Atlantic and the Mediterranean, ranging from panmixia to noticeable population genetic structure. Here, we used mitochondrial sequence data to analyse connectivity in the bogue Boops boops throughout most of its widespread distribution. Our results identified the existence of three clades, one comprising specimens from the Azores and eastern Atlantic/Mediterranean, another with individuals from the Canary Islands, Madeira and Cape Verde archipelagos, and the third with samples from Mauritania only. One of the branches of the northern subtropical gyre (Azores Current) that drifts towards the Gulf of Cádiz promotes a closer connection between the Azores, southern Portugal and the Mediterranean B. boops populations. The Almería-Oran Front, widely recognised as an oceanographic barrier for many organisms to cross the Atlantic-Mediterranean divide, does not seem to affect the dispersal of this benthopelagic species. The southward movement of the Cape Verde Frontal Zone during the winter, combined with the relatively short duration of the pelagic larval stage of B. boops, may be potential factors for preventing the connectivity between the Atlantic oceanic archipelagos and Mauritania shaping the genetic signature of this species.
Molecular signatures in the progression of COVID-19 severity
Authors: De Ronika , Azad Rajeev K. 
Published: December 2022

AbstractSARS-CoV-2 is the causative agent of COVID-19 that has infected over 642 million and killed over 6.6 million people around the globe. Underlying a wide range of clinical manifestations of this disease, from moderate to extremely severe systemic conditions, could be genes or pathways differentially expressing in the hosts. It is therefore important to gain insights into pathways involved in COVID-19 pathogenesis and host defense and thus understand the host response to this pathogen at the physiological and molecular level. To uncover genes and pathways involved in the differential clinical manifestations of this disease, we developed a novel gene co-expression network based pipeline that uses gene expression obtained from different SARS-CoV-2 infected human tissues. We leveraged the network to identify novel genes or pathways that likely differentially express and could be physiologically significant in the COVID-19 pathogenesis and progression but were deemed statistically non-significant and therefore not further investigated in the original studies. Our network-based approach aided in the identification of co-expression modules enriched in differentially expressing genes (DEGs) during different stages of COVID-19 and enabled discovery of novel genes involved in the COVID-19 pathogenesis, by virtue of their transcript abundance and association with genes expressing differentially in modules enriched in DEGs. We further prioritized by considering only those enriched gene modules that have most of their genes differentially expressed, inferred by the original studies or this study, and document here 7 novel genes potentially involved in moderate, 2 in severe, 48 in extremely severe COVID-19, and 96 novel genes involved in the progression of COVID-19 from severe to extremely severe conditions. Our study shines a new light on genes and their networks (modules) that drive the progression of COVID-19 from moderate to extremely severe condition. These findings could aid development of new therapeutics to combat COVID-19.