bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines
Authors: Węgierek-Ciura Katarzyna , Mierzejewska Jagoda , Szczygieł Agnieszka , Rossowska Joanna , Wróblewska Anna , Świtalska Marta , Goszczyński Tomasz M. , Szermer-Olearnik Bożena , Pajtasz-Piasecka Elżbieta 
Published: July 2023

BackgroundThe tumor microenvironment (TME) provides a conducive environment for the growth and survival of tumors. Negative factors present in TME, such as IL-10, may limit the effectiveness of cellular vaccines based on dendritic cells, therefore, it is important to control its effect. The influence of IL-10 on immune cells can be abolished e.g., by using antibodies against the receptor for this cytokine - anti-IL-10R. Furthermore, the anticancer activity of cellular vaccines can be enhanced by modifying them to produce proinflammatory cytokines, such as IL-12, IL-15 or IL-18. Additionally, an immunomodulatory dose of methotrexate and hydroxyethyl starch (HES-MTX) nanoconjugate may stimulate effector immune cells and eliminate regulatory T cells, which should enhance the antitumor action of immunotherapy based on DC vaccines. The main aim of our study was to determine whether the HES-MTX administered before immunotherapy with anti-IL-10R antibodies would change the effect of vaccines based on dendritic cells overproducing IL-12, IL-15, or IL-18.MethodsThe activity of modified DCs was checked in two therapeutic protocols - immunotherapy with the addition of anti-IL10R antibodies and chemoimmunotherapy with HES-MTX and anti-IL10R antibodies. The inhibition of tumor growth and the effectiveness of the therapy in inducing a specific antitumor response were determined by analyzing lymphoid and myeloid cell populations in tumor nodules, and the activity of restimulated splenocytes.Results and conclusionsUsing the HES-MTX nanoconjugate before immunotherapy based on multiple administrations of anti-IL-10R antibodies and cellular vaccines capable of overproducing proinflammatory cytokines IL-12, IL-15 or IL-18 created optimal conditions for the effective action of these vaccines in murine colon carcinoma MC38 model. The applied chemoimmunotherapy caused the highest inhibition of tumor growth in the group receiving DC/IL-15/IL-15Rα/TAg + DC/IL-18/TAg at the level of 72.4%. The use of cellular vaccines resulted in cytotoxic activity increase in both immuno- or chemoimmunotherapy. However, the greatest potential was observed both in tumor tissue and splenocytes obtained from mice receiving two- or three-component vaccines in the course of combined application. Thus, the designed treatment schedule may be promising in anticancer therapy.
Cognitive impairments predict the behavioral and psychological symptoms of dementia
Authors: Hemrungrojn Solaphat , Tangwongchai Sookjaroen , Charernboon Thammanard , Phanasathit Muthita , Chaipresertsud Pisit , Maleevach Pacharaporn , Likitjaroen Yuttachai , Phanthumchinda Kammant , Assawatinna Ratiya , Amrapala Arisara , Maes Michael 
Published: July 2023

IntroductionThe purpose of this study was to (1) validate the Thai version of the Neuropsychiatric Inventory Questionnaire (NPI-Q) as a screening tool for behavioral and psychological symptoms of dementia (BPSD), and (2) examine the relationship between cognitive performance and BPSD in an elderly population with amnestic mild cognitive impairment (aMCI) and dementia of Alzheimer’s type (DAT).MethodsOne hundred and twenty participants, comprising 80 aMCI and 40 DAT patients, and their respective caregivers were included in the study. Participants completed the NPI-Q and the Neuropsychiatric Inventory (NPI) within 2 weeks of each other and cognitive performance was primarily assessed using the Montreal Cognitive Assessment (MoCA).ResultsThe Thai NPI-Q had good validity and reliability. Pure exploratory bifactor analysis revealed that a general factor and a single-group factor (with high loadings on delusions, hallucinations, apathy, and appetite) underpinned the NPI-Q domains. Significant negative correlations between the MoCA total score and the general and single-group NPI-Q scores were found in all subjects (aMCI + DAT combined) and DAT alone, but not in aMCI. Cluster analysis allocated subjects with BPSD (10% of aMCI and 50% of DAT participants) into a distinct “DAT + BPSD” class.ConclusionThe NPI-Q is an appropriate instrument for assessing BPSD and the total score is largely predicted by cognitive deficits. It is plausible that aMCI subjects with severe NPI-Q symptoms (10% of our sample) may have a poorer prognosis and constitute a subgroup of aMCI patients who will likely convert into probable dementia.
18F-FDG PET/CT radiomics for prediction of lymphovascular invasion in patients with early stage non-small cell lung cancer
Authors: Wang Jie , Zheng Zhonghang , Zhang Yi , Tan Weiyue , Li Jing , Xing Ligang , Sun Xiaorong 
Published: July 2023

ObjectiveTo explore a prediction model for lymphovascular invasion (LVI) on cT1–2N0M0 radiologic solid non-small cell lung cancer (NSCLC) based on a 2-deoxy-2[18F]fluoro-D-glucose ([18F]F-FDG) positron emission tomography-computed tomography (PET-CT) radiomics analysis.MethodsThe present work retrospectively included 148 patients receiving surgical resection and verified pathologically with cT1–2N0M0 radiologic solid NSCLC. The cases were randomized into training or validation sets in the ratio of 7:3. PET and CT images were used to select optimal radiomics features. Three radiomics predictive models incorporating CT, PET, as well as PET/CT images radiomics features (CT-RS, PET-RS, PET/CT-RS) were developed using logistic analyses. Furthermore, model performance was evaluated by ROC analysis for predicting LVI status. Model performance was evaluated in terms of discrimination, calibration along with clinical utility. Kaplan-Meier curves were employed to analyze the outcome of LVI.ResultsThe ROC analysis demonstrated that PET/CT-RS (AUCs were 0.773 and 0.774 for training and validation sets) outperformed both CT-RS(AUCs, 0.727 and 0.752) and PET-RS(AUCs, 0.715 and 0.733). A PET/CT radiology nomogram (PET/CT-model) was developed to estimate LVI; the model demonstrated conspicuous prediction performance for training (C-index, 0.766; 95%CI, 0.728–0.805) and validation sets (C-index, 0.774; 95%CI, 0.702–0.846). Besides, decision curve analysis and calibration curve showed that PET/CT-model provided clinically beneficial effects. Disease-free survival and overall survival varied significantly between LVI and non-LVI cases (P&lt;0.001).ConclusionsThe PET/CT radiomics models could effectively predict LVI on early stage radiologic solid lung cancer and provide support for clinical treatment decisions.
Weekly reciprocal relationships between job crafting, work engagement, and performance—a within-person approach
Authors: Lopper Elisa , Milius Marvin , Reis Dorota , Nitz Sandra , Hoppe Annekatrin 
Published: July 2023

IntroductionFollowing the principles of the conservation of resources theory, this study explored whether job crafting, work engagement, and performance are reciprocally related from one week to the next.MethodData (N = 175) from a weekly diary study were analyzed using a random intercept cross-lagged panel model (RI-CLPM) to differentiate between stable trait-like between-unit and state-like within-person components.ResultsThe results revealed that, within weeks, job crafting, work engagement, and performance are associated with each other. Across weeks, on average, job crafting levels predicted work engagement and performance at the within-person level the following week. Inversely, work engagement, on average, predicted job crafting the next week, providing evidence for a positive cycle between both variables. Finally, work engagement and performance were reciprocally related from one week to the next, although the effects varied significantly in magnitude and direction.DiscussionOverall, the within-person relationships between job crafting, work engagement, and performance were more heterogeneous than anticipated.
Diversity awareness, diversity competency and access to healthcare for minority groups: perspectives of healthcare professionals in Croatia, Germany, Poland, and Slovenia
Authors: Ramšak Mojca , Orzechowski Marcin , Bielińska Katarzyna , Chowaniec Anna , Doričić Robert , Nowak Marianne , Skuban-Eiseler Tobias , Tutić Grokša Ivana , Łuków Paweł , Muzur Amir , Zupanič-Slavec Zvonka , Steger Florian 
Published: July 2023

IntroductionDue to cultural, language, or legal barriers, members of social minority groups face challenges in access to healthcare. Equality of healthcare provision can be achieved through raised diversity awareness and diversity competency of healthcare professionals. The aim of this research was to explore the experiences and attitudes of healthcare professionals toward the issue of social diversity and equal access to healthcare in Croatia, Germany, Poland, and Slovenia.MethodsThe data reported come from semi-structured interviews with n = 39 healthcare professionals. The interviews were analyzed using the methods of content analysis and thematic analysis.ResultsRespondents in all four countries acknowledged that socioeconomic factors and membership in a minority group have an impact on access to healthcare services, but its scope varies depending on the country. Underfunding of healthcare, language barriers, inadequate cultural training or lack of interpersonal competencies, and lack of institutional support were presented as major challenges in the provision of diversity-responsive healthcare. The majority of interviewees did not perceive direct systemic exclusion of minority groups; however, they reported cases of individual discrimination through the presence of homophobia or racism.DiscussionTo improve the situation, systemic interventions are needed that encompass all levels of healthcare systems – from policies to addressing existing challenges at the healthcare facility level to improving the attitudes and skills of individual healthcare providers.
The Impact of COVID-19 on the Epidemiology and Outcomes of Candidemia: A Retrospective Study from a Tertiary Care Center in Lebanon
Authors: El Zakhem Aline , Mahmoud Omar , Zakhour Johnny , Nahhal Sarah B. , El Ghawi Nour , Omran Nadine , El Sheikh Walaa G. , Tamim Hani , Kanj Souha S. 
Published: July 2023

Invasive fungal infections, notably candidemia, have been associated with COVID-19. The epidemiology of candidemia has significantly changed during the COVID-19 pandemic. We aim to identify the microbiological profile, resistance rates, and outcomes of COVID-19-associated candidemia (CAC) compared to patients with candidemia not associated with COVID-19. We retrospectively collected data on patients with candidemia admitted to the American University of Beirut Medical Center between 2004 and 2022. We compared the epidemiology of candidemia during and prior to the COVID-19 pandemic. Additionally, we compared the outcomes of critically ill patients with CAC to those with candidemia without COVID-19 from March 2020 till March 2022. Among 245 candidemia episodes, 156 occurred prior to the pandemic and 89 during the pandemic. Of the latter, 39 (43.8%) were CAC, most of which (82%) were reported from intensive care units (ICU). Non-albicans Candida (NAC) spp. were predominant throughout the study period (67.7%). Candida auris infection was the most common cause of NAC spp. in CAC. C. glabrata had decreased susceptibility rates to fluconazole and caspofungin during the pandemic period (46.1% and 38.4%, respectively). The mortality rate in the overall ICU population during the pandemic was 76.6%, much higher than the previously reported candidemia mortality rate observed in studies involving ICU patients. There was no significant difference in 30-day mortality between CAC and non-CAC (75.0% vs. 78.1%; p = 0.76). Performing ophthalmic examination (p = 0.002), CVC removal during the 48 h following the candidemia (p = 0.008) and speciation (p = 0.028) were significantly associated with a lower case-fatality rate. The epidemiology of candidemia has been significantly affected by the COVID-19 pandemic at our center. Rigorous infection control measures and proper antifungal stewardship are essential to combat highly resistant species such as C. auris.
Treatment results of children and adolescents with relapsed AML who were initially treated according to the AML-MM-2006 protocol
Authors: Kalinina I. I. , Venyov D. A. , Goronkova O. V. , Baydildina D. D. , Voronin K. A. , Maschan M. A. , Maschan A. A. 
Published: July 2023

Introduction. Relapse of acute myeloid leukemia (AML) develops in children who received intensive chemotherapy and achieved the first complete remission (CR1). Only intensive anti-relapse chemotherapy followed by allogeneic hematopoietic cell transplantation (allo-HSCT) may lead to cure.Aim — to present the results of treatment of children with AML who relapsed after completion of treatment or while on therapy according to the AML-MM-2006 protocol.Materials and methods. The study included children with AML who relapsed after completion of treatment of the first-line therapy according to the AML-MM-2006 protocol. During the follow-up period (median — 4.6 years), 68 relapses were registered among 187 patients who reached CR1 (early — 36, late — 26; with a change of phenotype to ALL-6). The cumulative probability of relapse was 40 %. Four (6 %) patients with relapsed AML initially belonged to the group of standard, 33 (54 %) — of intermediate risk of relapse of AML and 25 (40 %) — to the group of high risk. Eleven (18 %) were patients with “CBF-leukemia”, 19 (31 %) — with rearrangements of the 11q23 (KMT2A gene). Fludarabine, high doses of cytarabine and idarubicin in 33 (80 %) or mitoxantrone in 8 (20 %) patients were used to induce the second complete remission (CR2) in 41 patients (66 %).Results. Out of 53 patients who received chemotherapy as a second induction therapy, CR2 was achieved in 30 patients (57 %) (in 9 — with early, in 21 — with late relapse) after chemotherapy courses; 2 patients died within 30 days of the start of CT; 21 patients were refractory to chemotherapy. HSCT after relapse was performed in 51 patients, mainly from a haploidentical donor. Twenty-five patients underwent HSCT in CR2, 26 — in the status of “active disease”. Among patients transplanted into CR2, the probability of relapse was 20 %, and the overall survival rate was 80 %. Among patients transplanted outside of CR2, the probability of achieving CR2 was 77 %, the probability of relapse was 50 % and overall survival (OS) 58 %. The probability of OS in the group as a whole reached 52 %. The most significant prognostic factors of an unfavorable outcome were early relapse, refractory course of relapse, M7 variant of AML, complex karyotype and rearrangements of the ETV6 gene, combined (“bone marrow + CNS damage + non-hematopoietic tissue”) relapse and relapse after HSCT performed in CR1.Conclusion. About 50 % of patients with relapses of AML can be cured with the help of high-dose chemotherapy and allo-HSCT.
Storage of pathogen-reduced platelets
Authors: Rozhkov E. V. , Kozhemiako O. V. , Rozhkova N. S. , Kurmanova O. V. , Davidovich M. A. , Pokhabov D. S. , Madzaev S. R. 
Published: July 2023

Introduction. To improve the infectious safety of blood products, methods of pathogen inactivation in the donor container are used. Two technologies for pathogen inactivation in platelet concentrates have been approved in Russia: Intercept (amotosalen and ultraviolet A) and Mirasol (ribofl avin and ultraviolet).Aim — to study the quality parameters of stored pathogen-reduced platelet concentrates.Materials and methods. The platelet concentrate obtained by automatic plateletpheresis and resuspended in plasma was subjected to pathogen inactivation (PI), and samples were taken for research on the first day of storage before and after PI, as well as on the third and fifth days of storage. The volume of the dose and the number of cells were determined in 60 samples: 30 each, which underwent PI using the Intercept and Mirasol methods. The study of the pH level was performed in 46 platelet concentrates treated with Intercept and 38 containers treated with Mirasol. The characteristics of donors were also taken into account: gender, age, height, weight, and number of donations. The results were evaluated by descriptive statistics and analysis at a significance level of p < 0.05.Results. In the compared groups, there were no differences in the gender of donors, their donor experience, and anthropometric and hematological parameters. The number of platelets within 3 days in both groups did not differ both from the initial one and between the groups. On day 5, the number of Intercept platelets remained unchanged, and the number of Mirasol platelets significantly decreased both compared with the baseline (425.2 ± 31.0 × 109 vs. 519.6 ± 31.2 × 109, respectively, p < 0.001) and relative to Intercept platelets (425.2 ± 31.0 × 109 vs. 501.9 ± 32.8 × 109, respectively, p < 0.001). During the storage of platelet concentrates, the internal environment of the containers changed to the acidic side, and on day 5, the pH of Mirasol platelets was significantly more acidic than in the comparison group (6.51 ± 0.15 vs. 6.93 ± 0.15, respectively, р < 0.05).Conclusion. It was found that on day 5 of storage of Mirasol-platelets, the number of cells and pH significantly decreased compared to Intersept-platelets.
Haemovigilance in the United Kingdom
Authors: Pokhabov D. S. , Shestakov E. A. , Matveev S. A. , Shalygin L. D. , Zhiburt E. B. 
Published: July 2023

Introduction. Haemovigilance is the set of surveillance procedures covering the entire blood transfusion chain, from the donation and processing of blood and its components, through to their provision and transfusion to patients, including patient follow-up. The United Kingdom (UK) haemovigilance system has been developing for 25 years and is one of the world's leading hemovigilance systems.Aim — to review the analysis of adverse events in the UK blood service in 2021.Methods. Analysis of the British haemovigilance system report for 2021.Results. Blood transfusion remains safe in the UK, with a risk of death from a blood transfusion of 0.92 per 100,000 components issued. Transfusion delays and pulmonary complications (mostly circulatory overload) were responsible for 77.1 % (27 out of 35) of blood transfusion-related deaths in 2021. Errors (including near miss cases) still make up the majority of reports. In 2021, 2569 out of 3161 (81.3 %) of all reports were associated with errors. Prerequisites for reactions still make up a significant proportion: 1155/3161 (36.5 %) incidents. Understaffing, lack of proper training, poor supervision and poor safety culture have been identified as contributing factors to numerous incidents. They need to be addressed urgently to reduce the risk to patient safety. Ensuring the safety of process-based transfusions through a multi-pronged approach, proper training, appropriate resources, user-centric design, and learning by doing are essential. Reassignment warnings in laboratory health information systems continue to contribute to error reporting. Trends in abnormal transfusion reactions such as febrile, allergic, hypotensive and hemolytic reactions are similar to previous years. All personnel involved in blood transfusion should be competent and confident in recognizing and appropriately treating transfusion reactions in recipients.Conclusion. Haemovigilance is an important tool for improving the efficiency and safety of blood transfusion.
Bias in Polarization CLEAN Imaging
Authors: Himes Morgan , Jagannathan Preshanth 
Published: July 2023

Abstract
Various deconvolution algorithms, such as Hogbom CLEAN, have been developed to construct radio images of the sky. The algorithms used for synthesis imaging in CASA are sub-optimal for polarimetric imaging of sources with nonzero rotation measures. This method focuses on linear polarization in Stokes Q and U and the bias introduced in cleaning linearly polarized sources. We propose a hybrid method of cleaning based on QU fitting to reduce this bias. This method acquires a fit for a source's spectral index, polarization angle, Stokes I amplitude, polarized fraction, and rotation measure from a dirty image and uses these parameters to form a model that is fed into CASA for cleaning. Preliminary results show that this method cleans faster than the existing CASA task but introduces some degeneracies that need to be resolved prior to polarimetric imaging.
Stability assessment of organic sulfur and organosulfate compounds in filter samples for quantification by Fourier- transform infrared spectroscopy
Authors: Anunciado Marife B. , De Boskey Miranda , Haines Laura , Lindskog Katarina , Dombek Tracy , Takahama Satoshi , Dillner Ann M. 
Published: July 2023

Abstract. Organic sulfur and sulfate compounds, which are tracers for sources and
atmospheric processes, are not currently measured in national monitoring
networks such as the Interagency Monitoring of Protected Visual Environments
(IMPROVE). The goal of this paper is to begin to assess the stability of
organic sulfur and sulfate-containing compounds on polytetrafluoroethylene
(PTFE) filters and the suitability of Fourier-transform infrared (FT-IR)
spectroscopy to measure these compounds. Stability assessment is needed
because PTFE samples collected by IMPROVE are typically stored 6–9 months
prior to analysis. For this study, two organosulfur compounds,
methanesulfonic acid (MSA) and hydroxymethanesulfonate ion (HMS), and two
organosulfate compounds, methyl sulfate (MS) and 2-methyltetrol sulfate
(2-MTS), are collected individually on PTFE filters. Gravimetric mass
measurements are used to assess mass stability over time. FT-IR spectra are
evaluated to assess the capability of measuring the compound from PTFE
filters by assessing the compound stability or chemical changes over time.
Ion chromatography (IC) and inductively coupled plasma optical emission
spectroscopy (ICP-OES) are used as additional tools to assess stability or
chemical changes over time. MS has the highest potential to be measured by
FT-IR in IMPROVE samples. For MS, a simple organosulfate, the mass changes
are within measurement uncertainty and FT-IR spectra indicate no
compositional change over a 4-month period, suggesting that MS can be measured
using FT-IR. IC and ICP-OES support the conclusion that MS is stable on the
filter. However, for 2-MTS, the other organosulfate measured in this study,
spectral changes after a month on the filter suggest that it decomposes into
other organosulfates or an inorganic sulfate. MSA in IMPROVE samples can be
measured, but only as a lower bound, due to volatility off the filter as
indicated by FT-IR and gravimetry. FT-IR and IC both show that MSA does not
chemically change over the course of the study. Measurements by all
methods indicate that HMS is unstable on the PTFE filter, and IC and FT-IR indicate
that it likely converts to inorganic sulfate. Future work includes the
evaluation of these compounds in an ambient aerosol sample matrix to
determine any differences in stability, identifying interference that could
limit quantification, and developing calibrations to measure the compounds or
functional groups in ambient samples.