bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding public protective behavioural intention during the COVID‐19 pandemic: Moderating effects of proxy efficacy and collective efficacy
Authors: Cheng Peng , Zhou YaPing , Zhou Shuang , Yang Shu 
Published: February 2023

AbstractPublic efficacy beliefs against COVID‐19 might affect a person's coping strategy toward infection control. This study presented a synthetic conceptual model based on the Integrative Model of Behavioural Prediction (IMBP). We examined inductively the relationships among media exposure, efficacy beliefs, attribution of responsibilities and recommended protective behavioural intention using a survey of 435 participants who experienced the epidemic in China. Results suggest that traditional media exposure could stably and consistently enhance people's self‐efficacy, collective efficacy as well as proxy efficacy, whereas social media exposure only increases the degree of self‐efficacy. Furthermore, we detect that protective behavioural intention is directly affected by self‐efficacy and indirectly affected by collective efficacy and proxy efficacy via the mediation of self‐efficacy. At the same time, the influence of self‐efficacy on attribution of responsibilities and protective behaviours can be moderated by collective efficacy and proxy efficacy, respectively.
Removing Barriers to Whistleblowing at Nonprofit Organizations through Employee Empowerment*
Authors: Arroyo Pardo Paulina , Smaili Nadia , Bensid Souad 
Published: February 2023

AbstractThis study explores how key organizational and governance actors perceive the effectiveness of whistleblowing at nonprofit organizations (NPOs) and how whistleblowing is interrelated with other anti‐fraud mechanisms. Using a systems approach, we develop a conceptual framework of anti‐fraud mechanisms consisting of a set of interrelated components: control‐focused mechanisms and employee‐focused mechanisms (whistleblowing) intended to prevent and detect fraud, influenced by the environment (regulation and stakeholders) and human factors (employees' attitudes and leaders' awareness of fraud). We conducted 14 semistructured interviews with key actors at Canadian NPOs and noted that diverse control mechanisms were in place at these groups, but seemingly no formal whistleblowing policy existed. The organizations were disinclined to formalize a whistleblowing system in the short term despite viewing such a system as effective. Whereas prior research has examined the role of control‐focused mechanisms, NPOs' adoption of whistleblowing systems, and the benefits thereof, we contribute to the literature by stressing that employee empowerment is crucial to overcoming reluctance to blow the whistle. If the board of directors is aware of fraud risk and provides employees with the resources, motivation, and protection to speak up, whistleblowing could be implemented in these organizations. Whistleblowing should be interrelated with other mechanisms to form an effective anti‐fraud system.
Risk of readmission among individuals with cannabis use disorder during a 15‐year cohort study: the impact of socio‐economic factors and psychiatric comorbidity
Authors: Rabiee Rynaz , Sjöqvist Hugo , Agardh Emilie , Lundin Andreas , Danielsson Anna‐Karin 
Published: February 2023

AbstractBackground and aimCannabis use disorder (CUD) is one of the main reasons for seeking substance treatment in the Nordic countries, but there are few studies on readmission to care. We aimed to characterize CUD readmission and estimate the magnitude of how socio‐economic factors and psychiatric comorbidity influence the risk of CUD readmission.Design, Setting and ParticipantsThis was a nation‐wide cohort study carried out between 2001 and 2016 in Sweden. The participants were individuals with CUD, aged 17 years and above (n = 12 143).MeasurementsInformation on predictors was obtained from registers and included education, income and psychiatric comorbidity assessed by six disease groups. The outcome measure was readmission, defined as a CUD visit to health‐care at least 6 months after initial CUD diagnosis. Hazard ratios (HR) were estimated using Cox survival analyses and flexible parametric survival analyses to assess risk of readmission and how the risk varied with age.FindingsThe vast majority of CUD visits took place in outpatient care (~80%). Approximately 23% of the included individuals were readmitted to care during follow‐up. The fully adjusted model showed an increased risk of readmission among those with schizophrenia and other psychotic disorders [HR = 1.54, 95% confidence interval (CI) = 1.29–1.84], low education (HR = 1.40, 95% CI = 1.24–1.57), personality disorders (HR = 1.27, 95% CI = 1.05–1.54) or mood disorders (HR = 1.27, 95% CI = 1.12–1.45). Flexible parametric modeling revealed increased risk of readmission mainly in individuals aged 18–35 years.ConclusionsThe risk of readmission was highest among those with low education, schizophrenia and other psychotic disorders, mood‐related disorders or personality disorders. Individuals aged 18–35 years showed the highest risk of readmission. Our findings highlight individuals with complex health‐care needs.
Terrorist Attacks, Cultural Incidents, and the Vote for Radical Parties: Analyzing Text from Twitter
Authors: Giavazzi Francesco , Iglhaut Felix , Lemoli Giacomo , Rubera Gaia 
Published: February 2023

AbstractWe study the role of perceived threats from other cultures induced by terrorist attacks and criminal events on public discourse and support for radical‐right parties. We develop a rule which allocates Twitter users to electoral districts in Germany and use a machine‐learning method to compute measures of textual similarity between the tweets they produce and tweets by accounts of the main German parties. Using the exogenous timing of attacks, we find that, after an event, Twitter language becomes on average more similar to that of the main radical‐right party, AfD. The result is driven by a larger share of tweets discussing immigrants and Muslims, common AfD topics, and by a more negative sentiment of these tweets. Shifts in language similarity are correlated with changes in vote shares between federal elections. These results point to the role of perceived threats from minorities on the success of nationalist parties.
TENT5D disruption causes oligoasthenoteratozoospermia and male infertility
Authors: Sha Yanwei , Liu Wensheng , Tang Songxi , Zhang Xiaoya , Xiao Ziyi , Xiao Yuwei , Deng Hongjing , Zhou Huiliang , Wei Xiaoli 
Published: February 2023

AbstractBackgroundOligoasthenoteratozoospermia (OAT) is one of the most complex aggregators of male gametic problems. However, the genetic etiology of OAT is still largely unknown.ObjectivesTo reveal the new genetic factors responsible for male infertility owning to OAT and reveal the outcomes of the affected patients from intracytoplasmic sperm injection (ICSI).Materials and methodsTwo infertile men with typical OAT were recruited in 2018 and retrospected a cohort that included 47 patients with OAT from 2013 to 2021. Fifty healthy men with proven fertility served as control subjects. To identify the novel pathogenic variants, whole‐exome sequencing and Sanger sequencing were used. In silico analysis revealed the affecting of the variants. Field emission scanning electron microscopy was employed to observe the morphological defects of the spermatozoa. Immunofluorescence was used to analyze the expression and localization of the related protein. CRISPR/Cas9 was used to generate the mouse model. ICSI was used as a treatment for the patients and to assess the effects of the pathogenic variant on fertilization and embryo development.ResultsWe identified a loss‐of‐function mutation NM_001170574.2:c.823G > T (p.Glu275*) in X‐linked TENT5D from two patients with OAT. This variant is highly deleterious and has not been found in the human population. The count of patients’ spermatozoa is dramatically decreased and displays multiple morphologic abnormalities with poor motility. Tent5d knockout mice are infertile and exhibit parallel defects. ICSI could rescue the infertility of the Tent5d knockout male mice. Moreover, the proband was treated with ICSI and achieved a successful pregnancy outcome for the first time. Subsequent mutation screening identified no TENT5D mutations among 47 additional patients with OAT and 50 control subjects.ConclusionMutation in TENT5D results in OAT and male infertility, and this terrible situation could be rescued by ICSI.
Synthetic lethal targeting of TET2‐mutant haematopoietic stem and progenitor cells by XPO1 inhibitors
Authors: Jing Chang‐Bin , Prutsch Nicole , He Shuning , Zimmerman Mark W. , Landesman Yosef , Look A. Thomas 
Published: February 2023

SummaryTET2 inactivating mutations serve as initiating genetic lesions in the transformation of haematopoietic stem and progenitor cells (HSPCs). In this study, we analysed known drugs in zebrafish embryos for their ability to selectively kill tet2‐mutant HSPCs in vivo. We found that the exportin 1 (XPO1) inhibitors, selinexor and eltanexor, selectively kill tet2‐mutant HSPCs. In serial replating colony assays, these small molecules were selectively active in killing murine Tet2‐deficient Lineage‐, Sca1+, Kit+ (LSK) cells, and also TET2‐inactivated human acute myeloid leukaemia (AML) cells. Selective killing of TET2‐mutant HSPCs and human AML cells by these inhibitors was due to increased levels of apoptosis, without evidence of DNA damage based on increased γH2AX expression. The finding that TET2 loss renders HSPCs and AML cells selectively susceptible to cell death induced by XPO1 inhibitors provides preclinical evidence of the selective activity of these drugs, justifying further clinical studies of these small molecules for the treatment of TET2‐mutant haematopoietic malignancies, and to suppress clonal expansion in age‐related TET2‐mutant clonal haematopoiesis.
Homologous recombination inquiry through ovarian malignancy investigations: JGOG3025 Study
Authors: Yoshihara Kosuke , Baba Tsukasa , Tokunaga Hideki , Nishino Koji , Sekine Masayuki , Takamatsu Shiro , Matsumura Noriomi , Yoshida Hiroshi , Kajiyama Hiroaki , Shimada Muneaki , Kagimura Tatsuo , Oda Katsutoshi , Sasajima Yuko , Yaegashi Nobuo , Okamoto Aikou , Sugiyama Toru , Enomoto Takayuki 
Published: February 2023

AbstractThe Cancer Genome Atlas (TCGA) network has clarified that ~50% of high‐grade serous ovarian cancers show homologous recombination deficiency (HRD). However, the frequency of HRD in Japanese patients with ovarian cancer remains unclear. We aimed to identify the frequency of HR‐associated gene mutations in Japanese patients with ovarian cancer. The JGOG3025 study is a multicenter collaborative prospective observational study involving 65 study sites throughout Japan. We recruited 996 patients who were clinically diagnosed with ovarian cancer before surgery from March 2017 to March 2019, and 701 patients were eligible according to the criteria. We used frozen tumor tissues to extract DNA and performed next‐generation sequencing for 51 targeted genes (including 29 HR‐associated genes) in 701 ovarian cancers (298 high‐grade serous cases, 189 clear cell cases, 135 endometrioid cases, 12 mucinous cases, 3 low‐grade serous cases, and 64 others). HRD was defined as positive when at least one HR‐associated gene was mutated. The frequencies of HRD and tumor BRCA1/2 mutations were 45.2% (317/701) and 18.5% (130/701), respectively, in the full analysis set. Next, we performed multivariate Cox proportional hazards regression analysis for progression‐free survival (PFS) and overall survival (OS). Advanced‐stage ovarian cancer patients with HRD had adjusted hazard ratios of 0.72 (95% CI, 0.55–0.94) and 0.57 (95% CI, 0.38–0.86) for PFS and OS, respectively, compared with those without HRD (p = 0.016 and 0.007). Our study demonstrated that mutations in HR‐associated genes were associated with prognosis. Further studies are needed to investigate the prognostic impact of each HR‐associated gene in ovarian cancer.
Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes
Authors: Komohara Yoshihiro , Kurotaki Daisuke , Tsukamoto Hirotake , Miyasato Yuko , Yano Hiromu , Pan Cheng , Yamamoto Yutaka , Fujiwara Yukio 
Published: February 2023

AbstractTumor‐associated macrophages (TAMs) are the most prominent immune cells in the breast cancer microenvironment, and the protumor functions of TAMs are thought to affect cancer progression and resistance to anticancer therapy. Numerous studies using human breast cancer samples, cell lines, and murine breast cancer models have revealed details of the mechanisms by which the protumor functions of TAMs are activated. Recent advances have highlighted the significant involvement of TAMs in the resistance of breast cancer cells to immunotherapy. Tumor‐associated macrophages express a number of immunosuppressive genes, and single‐cell sequence analyses of human and murine cancer samples have helped elucidate the mechanism of TAM‐induced immunosuppression. As TAMs are considered suitable targets for anticancer therapies, we summarized the protumor functions of TAMs and the potential of anticancer therapies targeting TAMs, with a focus on breast cancer research.
Deciphering the modulatory role of apigenin targeting oncogenic pathways in human cancers
Authors: Pandey Pratibha , Khan Fahad , Upadhyay Tarun Kumar 
Published: February 2023

AbstractCancer is a complicated malignancy controlled by numerous intrinsic and extrinsic pathways. There has been a significant increase in interest in recent years in the elucidation of cancer treatments based on natural extracts that have fewer side effects. Numerous natural product‐derived chemicals have been investigated for their anticancer effects in the search for an efficient chemotherapeutic method. Therefore, the rationale behind this review is to provide a detailed insights about the anticancerous potential of apigenin via modulating numerous cell signaling pathways. An ingestible plant‐derived flavonoid called apigenin has been linked to numerous anticancerous potential in numerous experimental and biological studies. Apigenin has been reported to induce cell growth arrest and apoptotic induction by modulating multiple cell signaling pathways in a wider range of human tumors including those of the breast, lung, liver, skin, blood, colon, prostate, pancreatic, cervical, oral, and stomach. Oncogenic protein networks, abnormal cell signaling, and modulation of the apoptotic machinery are only a few examples of diverse molecular interactions and processes that have not yet been thoroughly addressed by scientific research. Thus, keeping this fact in mind, we tried to focus our review towards summarizing the apigenin‐mediated modulation of oncogenic pathways in various malignancies that can be further utilized to develop a potent therapeutic alternative for the treatment of various cancers.
Developmental changes in the structure of shyness and internalizing symptoms from early to middle childhood: A network analysis
Authors: Bekkhus Mona , McVarnock Alicia , Coplan Robert J. , Ulset Vidar , Kraft Brage 
Published: February 2023

AbstractShyness is a temperamental trait that shares considerable conceptual overlap with aspects of internalizing problems, creating difficulties in operationalizing and assessing these two constructs and their association. This study addresses these issues by employing network analyses. Participants were, white, N = 555 children (Mage = 52.45 months, SD = 15.96, 55% girls) followed longitudinally over 4 years (2016–2010) in Norway. Teachers rated child shyness and assessed children's internalizing symptoms. Results suggest that two behavioral shyness traits were the most central aspects of shyness. The centrality of these aspects was robust across age. The most influential symptom connecting internalizing symptoms with shyness was “unhappy.” Shyness became more differentiated with development, and associations between anxiety‐related symptoms and shyness increased as children entered formal schooling.
Why and how we can use data linkage in oral health research: a narrative review
Authors: Slack‐Smith Linda , Arena Gina 
Published: February 2023

AbstractObjectivesPoor oral health, impacting health and wellbeing across the life‐course, is a costly and wicked problem. Data (or record) linkage is the linking of different sets of data (often administrative data gathered for non‐research purposes) that are matched to an individual and may include records such as medical data, housing information and sociodemographic information. It often uses population‐level data or ‘big data’. Data linkage provides the opportunity to analyse complex associations from different sources for total populations. The aim of the paper is to explore data linkage, how it is important for oral health research and what promise it holds for the future.MethodsThis is a narrative review of an approach (data linkage) in oral health research.ResultsData linkage may be a powerful method for bringing together various population datasets. It has been used to explore a wide variety of topics with many varied datasets. It has substantial current and potential application in oral health research.ConclusionsUse of population data linkage is increasing in oral health research where the approach has been very useful in exploring the complexity of oral health. It offers promise for exploring many new areas in the field.
A content analysis of South Korean newspaper coverage of adolescent cyberbullying
Authors: Chun JongSerl , Kim Jinyung , Lee Serim 
Published: February 2023

AbstractThis study aims to understand the changing frameworks, perspectives and contents of cyberbullying over the years of enactment and amendments made to the School Violence Act. A total of 172 news articles published from 2004 to 2021 were first analysed by content and with a chronological segmentation strategy. In the early years, newspapers reported mostly verbal/written and sexual/visual cyberbullying, while exclusion/extortion emerged only recently. The causes of cyberbullying changed from more individual‐oriented ones to societal factors. Physical and psychological harms were consistently reported, but few indicated relational harms. Nowadays, laws/policies are gaining more emphasis as a solution to cyberbullying than services and/or interventions.
Obstructive sleep apnea and vitamin D level: Has the dust settled?
Authors: Loh Huai Heng , Sukor Norlela 
Published: February 2023

AbstractObstructive sleep apnea and vitamin D deficiency are associated with multiple complications with increased morbidity and mortality. However, the relationship between these two entities remains unclear, with clinical studies demonstrating contradictory results. This narrative review aims to present the current evidence and understanding of this relationship and discuss the possible mechanisms linking these two disease entities. Finally, we summarize and propose areas of opportunity for future research.
The impact of surgical interventions on the psychosocial well‐being of patients with hidradenitis suppurativa
Authors: Scholl Lisa , Schneider‐Burrus Sylke , Fritz Björn , Sabat Robert , Bechara Falk G. 
Published: February 2023

SummaryBackground and objectivesHidradenitis suppurativa is a chronic inflammatory skin disease. Depending on disease severity, a combination of conservative and surgical treatments is necessary. This analysis aimed to determine the impact of surgical interventions on patient psychosocial well‐being.Patients and methodsThis is a prospective, noninterventional, multicenter study. The medical history, medical examination, and patient‐reported outcomes, including the Hospital Anxiety and Depression Scale, Dermatology Life Quality Index, and the Short Form‐12 Health Survey, were collected from 481 patients with hidradenitis suppurativa.ResultsAmong all patients with hidradenitis suppurativa included in this study, 74.2% reported surgery before study inclusion, of whom 92.4% could identify surgery type and location. Although adjusted for confounding factors, such as disease severity and activity, the aforementioned patient reported outcomes, did not vary significantly between groups of patients with different techniques and number of prior surgical intervention. However, patients without any prior surgical intervention yielded significantly better scores.ConclusionsIn patients with hidradenitis suppurativa, previous surgery was associated with worse outcomes in anxiety, depression, and quality of life, showing the apparent need of psychological support. It remains unclear whether the morbidity of surgical procedures or a possible higher severity score in patients undergoing surgery is responsible.
Image‐based response assessment during immunotherapy in skin cancer
Authors: Mayer Kristine E. , Gaa Jochen , Biedermann Tilo , Posch Christian 
Published: February 2023

SummaryImmune‐checkpoint inhibitors and further immunotherapeutic treatment strategies have significantly extended therapy options for melanoma and other skin cancer entities over the last decade. In the context of a broader application of immunotherapeutic approaches, sufficient ways to monitor the course of the disease during therapy are required. Immunotherapies are based on different ways of modulating the immune system. This leads to complex clinical response patterns including pseudoprogression and others, requiring an adaptation of conventional diagnostic imaging tools or the introduction of novel technologies. In this review, current non‐invasive imaging approaches for response assessment during immunotherapies in skin cancers as well as their limitations are discussed. To overcome present hurdles, promising alternatives to better address novel imaging features during immunotherapy are depicted giving an outlook on what can be expected in the future.
Management of rare inherited bleeding disorders: Proposals of the French Reference Centre on Haemophilia and Rare Coagulation Disorders
Authors: Trossaert Marc , Chamouard Valerie , Biron‐Andreani Christine , Casini Alessandro , De Mazancourt Philippe , De Raucourt Emmanuelle , Drillaud Nicolas , Frotscher Birgit , Guillet Benoit , Lebreton Aurelien , Roussel‐Robert Valerie , Rugeri Lucia , Dargaud Yesim 
Published: February 2023

AbstractIntroductionThe rare coagulation disorders may present significant difficulties in diagnosis and management. In addition, considerable inter‐individual variation in bleeding phenotype is observed amongst affected individuals, making the bleeding risk difficult to assess in affected individuals. The last international recommendations on rare inherited bleeding disorders (RIBDs) were published by the United Kingdom Haemophilia Centre Doctors' Organisation in 2014. Since then, new drugs have been marketed, news studies on surgery management in patients with RIBD have been published, and new orphan diseases have been described.AimTherefore, the two main objectives of this review, based on the recent recommendations published by the French Reference Centre on Haemophilia and Rare Bleeding Disorders, are: (i) to briefly describe RIBD (clinical presentation and diagnostic work‐up) to help physicians in patient screening for the early detection of such disorders; and (ii) to focus on the current management of acute haemorrhages and long term prophylaxis, surgical interventions, and pregnancy/delivery in patients with RIBD.