bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinical case of preservation of reproductive potential in a patient with invasive cervical cancer
Authors: Korneva O. V. , Trishkin A. G. , Chernyshova A. L. , Vyalova K. V. 
Published: August 2023

Cervical cancer is a malignant tumor originating from the mucous membrane of the cervix (ectocervix or endocervix). In 2020, 604,000 new cases of the disease were registered, with 342,000 deaths. Today, a significant rejuvenation of this pathology is recorded – the highest incidence rate occurs in the age group from 15 to 39 years.The cause of the development of cervical cancer is the human papillomavirus of oncogenic genotypes, and in Russia, human papillomavirus types 16 and 18 are found in most patients. Risk factors: early onset of sexual activity, frequent change of sexual partners, refusal of “barrier” type contraceptives, smoking, immunosuppression, the question of the influence of various sexually transmitted infections is being discussed.The present article describes a clinical case of performing an organ-preserving operation: laparoscopic extended trachelectomy with sentinel lymph nodes determination, urgent cytological and histological studies, with the formation of the obturator apparatus with a soft titanium nickelide implant for invasive cervical cancer in a patient with unrealized reproductive function.Organ-preserving surgeries in patients with cervical cancer allow preserving childbearing function while maintaining oncological radicality of surgical treatment. A modern, multidisciplinary approach of an oncologist-gynecologist and a reproductologist is the basis of a modern strategy for managing a patient with cervical cancer and unrealized reproductive function.
Incidence of postoperative complications in breast cancer patients depending on their tumor subtype and type of surgery
Authors: Ismagilov A. Kh. , Karasev V. E. , Vyushkov D. M. 
Published: August 2023

Background. Breast cancer is distinguished by its heterogeneity. The biological subtype of the tumor influences the choice of treatment tactics, components of complex therapy. The appearance of targeted drugs made it possible to expand the indications of reconstructive plastic surgery in patients with breast cancer.Aim. To study the influence of the biological subtype of breast tumor on the frequency of complications after simultaneous and delayed reconstructive plastic surgeries.Materials and methods. The postoperative period of 577 patients 18–40 years with a diagnosis of stage I–IIIA unilateral breast cancer was studied. In 61.2 %, luminal cancer, subtype A, was verified, in 6.1 % – luminal cancer, subtype B, in 10.4 % – HER2-positive (luminal) ER+PR+, in 7.3 % – HER2-positive (non-luminal) ER–PR–, in 15 % – three times negative. All patients underwent surgical treatment, including, taking into account the indications and contraindications, in the volume of Madden mastectomy – 43.5 %, mastectomy with simultaneous two-stage reconstruction with silicone implants – 34.8 %, mastectomy with delayed two-stage reconstruction with silicone implants – 21.7 %.Results. In most patients, the early postoperative period was favorable, complications were recorded in 11.8 %: in 11.3 % of patients of group I, 11.4 % of group II, 11.7 % of group III, 14.3 % of group IV, 12.6 % of group V. After radical mastectomy, complications were recorded in 13.5 % of cases, after mastectomy with simultaneous and delayed reconstruction – in 10.4 %. The treatment efficacy rate was 65.2–84.6 %. Late postoperative complications were recorded in group I in 24.1 % of patients, in group II – in 22.9 %, in group III – in 23.3 %, in group IV – in 26.2 %, in group V – in 24.1 %. Among patients who underwent only radical mastectomy, complications were noted in 24.7 %, mastectomy with simultaneous reconstruction – in 24.9 %, mastectomy with delayed reconstruction – in 21.6 %. The treatment efficacy rate was 42.9–59.5 %.Conclusion. Our study did not reveal a relationship between the incidence of early and late postoperative complications in patients with different biological tumor types. Based on the literature, it can be assumed that not the type of tumor, but individually prescribed systemic therapy makes a significant contribution to the development of postoperative complications, which should be taken into account when planning reconstructive plastic surgeries.
Prognostic value of FOXA1 in patients with Т1–2N0M0 breast cancer
Authors: Paltuev R. M. , Kudaybergenova A. G. , Semiglazov V. F. , Komyakhov A. V. , Tseluyko A. I. 
Published: August 2023

Background. New biomarkers of breast cancer are actively being studied to used them for breast cancer prognosis and develop optimal approaches to therapy. FOXA1 is one of these factors whose prognostic value for breast cancer has been analyzed in several studies.Aim. To evaluate the prognostic value of FOXA1 in patients with T1–2N0M0 breast cancer.Materials and methods. We measured FOXA1 expression in tumor cells of patients with hormone-dependent and hormone-independent breast cancer using the method developed by us (patent No. RU2748716C1 dated 03.06.2020). We performed immunohistochemical examination of tumor tissue using specific antibodies for staining. The Allred scale was used for results interpretation (to assess the number of cells with stained nuclei and the intensity of their staining). Then the total Allred score was calculated and used as a prognostic parameter. Patients with the Allred score between 4 and 8 had a favorable prognosis. We followed up patients in the groups and evaluated their survival. A univariate analysis was used to assess the risk of lethal outcome depending on the level of FOXA1 expression.Results. In 75 % of patients with hormone-dependent and 82 % of patients with hormone-independent breast cancer (stages T1–2, N0 in both groups), the prognostic parameter measured using the Allred scale ranged between 4 and 8 points; their 10-year overall survival was 93 % and 92 %, respectively.Conclusion. Our findings suggest high accuracy of our method for breast cancer prognosis. It can be used for breast cancer prognosis in early stages (T1–2, N0) and expands the range of techniques for breast cancer prognosis.
Male breast cancer. Clinical experience of the Russian Scientific Center of Roentgenradiology of the Ministry of Health of Russia
Authors: Khodorovich O. S. , Solodkiy V. A. , Astaturyan K. S. , Sherstneva T. V. , Kanakhina L. B. , Kleshneva V. O. , Tashchyan A. A. , Kalinina-Masri A. A. 
Published: August 2023

Interest in male breast cancer is increasing every year due to the increase in the spread of this disease. However, the lack of randomized trials in male breast cancer draws the attention of specialists to this problem. Male breast cancer is 100 times less common than female. Over the past decades, there has been an increase in the disease up to 26 %. Low awareness of general practitioners, as well as the male part of the population, untimely access to specialized specialists are the reasons for the late diagnosis of the disease. Recommendations for the treatment of male breast cancer are based on the results of studies conducted in female with a similar diagnosis.In the period from January 2015 to September 2022, 13 patients diagnosed with male breast cancer were examined and treated in the Department of Oncology and Reconstructive Plastic Surgery of the Breast of the Russian Scientific Center of Roentgenradiology, Ministry of Health of Russia. The age of patients at the time of treatment ranged from 58 to 75 years, with a mean age of 63 years. In 2 patients (15 %), stage 0 was established, in 4 (31 %) – stage Ia, in 4 (31 %) – stage IIa, in 1 (7.6 %) – stage IIb, in 1 (7.7 %) – stage IIIb, in 1 (7.6 %) – stage IIIc. Two (15 %) patients underwent neoadjuvant polychemotherapy, 6 (46 %) patients underwent adjuvant polychemotherapy. In 7 (54 %) patients, surgical treatment was performed without further adjuvant polychemotherapy. Six (46 %) patients underwent radiation therapy. Hormone therapy was prescribed to all 13 (100 %) patients. When contacting the clinic, the most frequent complaints would be the appearance of a seal behind the nipple, discharge from the nipple.When diagnosing male breast cancer, the same methods are used as female. Tactics of treatment is determined individually. Early diagnosis of the disease and timely prescribed therapy lead to many years of remission.
Representasi kekerasan seksual terhadap perempuan dalam Film “2037” (studi analisis semiotika Ferdinand de Saussure)
Authors: Nurhidayah Ika Amiliya , Bakhri Syamsul , Baharuddin M. Achwan 
Published: August 2023

One of the developments in communication technology that occurs today is the presence of various communication channels or 'media' in the process of delivering ideas, messages, or ideas. The variety of communication media has become the most effective method today in the formation of a person's point of view and behavior. In this study, researchers are interested in making one of the three types of communication media, namely audio-visual communication media in the form of films. Film is claimed to be a mass media that has a dominant influence than other media, this is due to the influence of psychology on films which is fundamental in the formation of opinions and people's psyche. Researchers are interested in examining a film entitled "2037" as a medium of representation of sexual violence against women. This study aims to identify signs or symbols that represent sexual violence against women in the 2037 film using Ferdinand de Saussure's semiotic theory as his analysis knife. The method applied in this study is qualitative with a data analysis model using semiotic analysis by Ferdinand de Saussure, which is based on signifiers and signified. The results and discussion showed that there were three types of sexual violence against women represented in the film "2037" based on markers and markers that had been found, including forced marriage, verbal abuse, and sexual harassment.
Salah satu perkembangan teknologi komunikasi yang terjadi saat ini adalah hadirnya alat saluran komunikasi atau 'media' yang beragam dalam proses penyampaian ide, pesan, ataupun gagasan. Beragamnya media komunikasi telah menjadi metode paling efektif saat ini dalam pembentukan sudut pandang dan perilaku seseorang. Dalam penelitian ini, peneliti tertarik untuk menjadikan salah satu dari ketiga jenis media komunikasi tersebut yaitu media komunikasi audio-visual berupa film. Film diklaim sebagai media massa yang memiliki pengaruh dominan daripada media lain, hal tersebut disebabkan karena adanya pengaruh psikologi pada film yang fundamental dalam pembentukan opini dan jiwa masyarakat. Peneliti tertarik untuk mengkaji sebuah film berjudul "2037" sebagai media representasi dari kekerasan seksual terhadap perempuan. Tujuan dari penelitian ini adalah untuk mengidentifikasi tanda-tanda atau simbol-simbol yang merepresentasikan kekerasan seksual terhadap perempuan dalam film 2037 dengan menggunakan teori semiotika Ferdinand de Saussure sebagai pisau analisisnya. Metode yang diaplikasikan dalam penelitian ini adalah metode kualitatif dengan model analisis data menggunakan analisa semiotika oleh Ferdinand de Saussure yang berprinsip pada penanda (signifier) dan pertanda (signified). Hasil dan pembahasan menunjukkan adanya 3 jenis kekerasan seksual terhadap perempuan yang direpresentasikan dalam film "2037” berdasarkan penanda dan petanda yang telah ditemukan, diantaranya adalah pemaksaan perkawinan, pelecehan verbal, dan pelecehan seksual.
Pengembangan media pembelajaran Majalah Inspiratif Sejarah (Manis) pada materi peran Raden Tumenggung Sosrokusumo I dalam islamisasi masyarakat Kabupaten Nganjuk Tahun 1830-1832 M
Authors: Fritambiradi Didit Ditya , Ayundasari Lutfiah 
Published: August 2023

This study aims to develop learning media in the form of an inspirational historical magazine 'MANIS' on the material of the role of Raden Tumenggung Sosrokusumo I in the Islamization of the people of Nganjuk Regency in 1830-1832 M in class XI IPS SMA Diponegoro Nganjuk based on the results of an analysis of the potential and problems of the research subjects. This study uses the Research and Development (R&D) method with a model developed by Sugiyono, covering potentials and problems, collecting data, product design, design validation, design revision, product trials, product revisions, usage trials, product revisions and mass production. However, this research and development only used nine of the ten steps of the procedural model. The analysis technique in this study uses qualitative analysis and quantitative descriptive. Based on the data validation results, 95 percent was obtained for material validation and 90 percent for media validation, while the small group trial obtained 74.8 percent and the large group trial obtained 85.3 percent. Based on these percentage values, it can be concluded that historical inspirational magazine learning media are valid and effective as historical learning media in class XI IPS SMA Diponegoro Nganjuk.
Penelitian ini memiliki tujuan untuk mengembangkan media pembelajaran berupa majalah inspiratif sejarah ‘MANIS’ pada materi peran Raden Tumenggung Sosrokusumo I dalam islamisasi masyarakat Kabupaten Nganjuk tahun 1830-1832 M pada kelas XI IPS SMA Diponegoro Nganjuk yang berdasarkan hasil analisis potensi dan masalah subjek penelitian. Penelitian ini menggunakan metode Research and Development (R&D) dengan model yang dikembangkan oleh Sugiyono, meliputi potensi dan masalah, mengumpulkan data, mendesain produk, validasi desain, revisi desain, uji coba produk, revisi produk, uji coba pemakaian, revisi produk dan produksi massal. Penelitian dan pengembangan ini hanya menggunakan sembilan langkah dari sepuluh langkah model prosedural tersebut. Teknik analisis dalam penelitian ini menggunakan analisis kualitatif serta deskriptif kuantitatif. Berdasarkan hasil validasi data mendapatkan nilai persentase 95 persen untuk validasi materi dan 90 persen untuk validasi media, sedangkan untuk uji coba kelompok kecil mendapatkan hasil 74,8 persen dan uji coba kelompok besar mendapatkan hasil 85,3 persen. Berdasarkan nilai persentase tersebut mendapatkan kesimpulan bahwa media pembelajaran majalah inspiratif sejarah valid dan efektif digunakan sebagai media pembelajaran sejarah di kelas XI IPS SMA Diponegoro Nganjuk.
Aciduria glutárica tipo I: reporte de un caso con diagnóstico tardío
Authors: López Rodríguez Victor Rubén de Jesús , Chima Galán María Del Carmen , Parra Guerrero Lina , Navarro Estrada Mariana , Santillán Hernández Yuritzi , Vargas Quevedo Ericka 
Published: August 2023

ANTECEDENTES: La aciduria glutárica tipo I es un error innato del metabolismo ocasionado por variantes en GCDH que dan origen a una deficiencia de la enzima glutaril-CoA deshidrogenasa que, a su vez, produce acumulación de metabolitos neurotóxicos y un cuadro clínico caracterizado por lesión estriatal y trastornos del movimiento (distonía, coreoatetosis).CASO CLÍNICO: Paciente de tres años de edad, previamente asintomático hasta el inicio de una crisis encefalopática a los 10 meses, posteriormente con regresión de hitos del desarrollo, hipotonía central y movimientos involuntarios. Con el antecedente de laringomalacia, orzuelos de repetición, tos productiva crónica, alteración en el patrón de evacuaciones, hiperhidrosis generalizada y múltiples hospitalizaciones por infecciones respiratorias. La resonancia magnética cerebral reportó aumento del espacio subaracnoideo frontotemporal bilateral y de las cisuras de Silvio, globo pálido, putamen y caudado con atrofia bilateral, hiperintensos en T2/FLAIR y con restricción a la difusión. El análisis de los ácidos orgánicos demostró elevación del ácido glutárico y la secuenciación de GCDH reportó dos variantes patogénicas: p.Arg402Trp y p.Thr429Met.
CONCLUSIONES: Se reporta un caso de aciduria glutárica tipo I con diagnóstico tardío y dos variantes patogénicas en GCDH no comunicadas previamente en población mexicana. El tratamiento oportuno de la aciduria glutárica tipo I cambia radicalmente el pronóstico; sin embargo, depende de métodos de cribado para el diagnóstico temprano, que no se encuentran disponibles en todas las poblaciones.
PENGARUH MODEL PROBLEM BASED LEARNING TERHADAP KEMAMPUAN SPATIAL THINKING SISWA SMA PADA PEMBELAJARAN GEOGRAFI
Authors: Mike Mike , Nofrion Nofrion 
Published: August 2023

Spatial thinking ability is a very important ability in geography and everyday life. Geography learning has basic concepts, principles and approaches related to spatial (spatial), students should have the ability to think spatially and must develop it. This study aims to determine the effect of problem-based learning models on the spatial thinking abilities of students of SMAN 15 Padang. The research design is Quasi Experimental with a pretest-posttest design-control group. The subjects of this research were class X.E students of SMAN 15 Padang. Class E1 as the control class and class E3 as the experimental class with 33 students per class. The data collection technique was obtained from a spatial thinking ability test that had been tested for validity and reliability. The test questions are designed based on indicators of spatial thinking abilities and geography subject matter. The data analysis technique used an independent sample t-test with a sig level of 0.05 and was supported by IBM SPSS Statistics 25.0. The results of the t-test analysis showed a Sig (2-tailed) of 0.000 less than 0.05 and the average value of the experimental class was greater (37) than the control class (31), which means that the PBL model had an effect on the spatial thinking abilities of SMAN 15 students Padang.
ABSTRAK
Kemampuan spasial thinking merupakan kemampuan yang sangat penting dalam geografi dan kehidupan sehari-hari. Pembelajaran geografi memiliki konsep dasar, prinsip dan pendekatan yang terkait dengan spasial (keruangan), siswa seharusnya memiliki kemampuan berpikir spasial dan harus mengembangkannya. Penelitian ini bertujuan mengetahui pengaruh model Problem Based Learning terhadap kemampuan spasial thinking siswa SMAN 15 Padang. Desain penelitian yaitu Quasi Experimental dengan pretest-posttest design-control group. Subjek penelitian ini adalah siswa kelas X.E SMAN 15 Padang. Kelas E1 sebagai kelas kontrol dan kelas E3 sebagai kelas eksperimen dengan jumlah siswa per kelas 33 orang. Teknik pengumpulan data diperoleh dari tes kemampuan spasial thinking yang telah diuji validitas dan reliabilitas. Soal-soal tes dirancang berdasarkan indikator dari kemampuan spasial thinking dan materi pelajaran geografi. Teknik analisis data menggunakan uji independent sample t-test dengan taraf sig 0,05 dan didukung oleh IBM SPSS Statistics 25.0. Hasil analisis uji-t menunjukkan Sig (2-tailed) sebesar 0,000 kurang dari 0,05 dan nilai rata-rata kelas eksperimen lebih besar (37) dibandingkan kelas kontrol (31), yang berarti model PBL berpengaruh terhadap kemampuan spasial thinking siswa SMAN 15 Padang.
POTENSI PEMBIASAAN SANITASI DAN PELAKSANAAN TRIAS UKS DI LEMBAGA PAUD KECAMATAN LOWOKWARU KOTA MALANG
Authors: Shafa Febbi 
Published: August 2023

Sanitation is one of the important factors in helping to create optimal growth and development in children, PAUD institutions are one of the key factors in creating and fostering sanitation habits, one of which is through the Triassic UKS program. The purpose of this paper is to determine sanitation habits in early childhood and the implementation of Triassic UKS in PAUD institutions, especially those in the Lowokwaru sub-district of Malang city. The approach used in this research is quantitative approach using survey method. The sampling technique in this study is purposive random sampling technique in PAUD institutions, namely KB/TK/RA and SPS (Similar PAUD Units) in the form of PAUD post. Meanwhile, the data analysis technique used is descriptive percentage analysis technique. The findings of the result show that most PAUD institutions in Lowokwaru sub district have the potential to carry out sanitation and Triassic UKS, but KB/TK/RA institutions are superior in carrying out both of these things compared to SPS (Similar PAUD Units) in the form of PAUD post.
Keywords: Sanitation, Triassic UKS, PAUD
Miradas femeninas sobre los exilios judío y español que México reunió
Authors: Houvenaghel Eugenia Helena , Ruelas Sara M. 
Published: August 2023

El presente número se centra en el trabajo y la trayectoria de escritoras (descendientes) de dos exilios emblemáticos —el judío y el español— en México. estos flujos de exiliados se reunieron en la sociedad mexicana y tuvieron su origen en persecuciones o en conflictos bélicos que ocurrieron en Europa durante la primera mitad del siglo XX. Las hijas y nietas de ambos exilios adoptaron en su obra nuevas perspectivas sobre el exilio y sobre las experiencias de sus ancestros. Por lo tanto, proponemos un enfoque intergeneracional que incluye mujeres escritoras de la primera, segunda y tercera generación de los exilios anteriormente mencionados.
Current Diagnostic Possibilities for the Initial Forms of External Endometriosis
Authors: Blazhnova E. M. , Oganesyan A. T. , Ibrahimova A. R. , Balter R. B. , Ivanova T. V. 
Published: August 2023

Background. Routine use of ultrasound methods does not always allow detecting endometriosis in the early stages. It is necessary to develop more accurate criteria for the diagnosis of endometriosis in its initial stages of development. Objective: to assess ultrasound and biological markers of endometriosis “small” forms of different localization in infertile women.Material and methods. Ultrasound examination of 208 infertile patients with initial stages of external endometriosis (1–15 points by revised American Fertility Society (rAFS) classificatoon) was performed (main group). The control group consisted of 195 healthy women of childbearing age. To verify the diagnosis, it is suggested to use a panel of biomarkers, including interleukins (IL) 1β and 6, CA125, HE4 as well as the ROMA (Risk of Ovarian Malignancy Algorithm) index in the dynamics of the menstrual cycle.Results. On ultrasound scans, 56 (94.9%) patients had small one- and two-sided ovarian cysts corresponding to endometriosis stage 1–2 (rAFS), and in 3 (5.4%) of them, the ultrasound result was questionable. Detectability during the initial ultrasound examination in the Douglas space was 76.9%, in the rest of cases the ultrasound picture was doubtful. Peritoneal endometriosis was detected only in 5 patients. In the remaining cases (88.9%), additional studies were necessary, including surgical (laparoscopy). The average content of CA125 in the main group on days 3–5 of the menstrual cycle was 42.6 (2.1) U/ml, on days 21–23 – 39.6(2.2) U/ml (p=0.32); in the control group, 5.1 (0.4) and 4.8 (0.7) U/ml, respectively (p = 0.71). The increase in CA125 in the main group was almost 8 times higher than in the control group, however, according to the indicators of HE4 and the ROMA index, statistically significant differences in the groups were not obtained. In the dynamics of the menstrual cycle, the content of ILs in the main group significantly decreased by days 21–23 of the cycle, while the content of CA125 and HE4 remained practically unchanged. Such sharp fluctuations of the considered biomarkers were not detected in the control group. However, even on days 21–23 of the cycle, the average content of ILs and CA125 in women of the main group remained statistically significantly higher than in the control group.Conclusion. In infertile women with dubious ultrasound criteria of external endometriosis, the use of IL1β and IL-6, which stimulate the immune inflammatory response, as well as tumor markers CA125, HE4 and ROMA index allows to differentiate the disease in the initial stages.