bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical observational study on the efficacy of induction chemotherapy sequential concurrent radiotherapy combined with targeted therapy in patients with locally advanced EGFR-positive nasopharyngeal carcinoma: prediction model construction and efficacy testing
Authors: Luo Yuanyuan , Xiang XueJing , Ma XiaoJie 
Published: August 2023

Abstract
Objective
To establish a nomogram for prediction of prognosis in EGFR-positive advanced nasopharyngeal carcinoma (NPC) patients who were treated with induction chemotherapy (IC) and concurrent chemoradiotherapy (CCRT). The clinical data of 124 NPC patients who received IC sequential CCRT combined with targeted therapy at the Department of Oncology of the Affiliated Hospital of North Sichuan Medical College between June 2017 and September 2022 were retrospectively reviewed. Logistic regression analysis was used to identify the prognostic factors for building the nomogram.

Results
Multifactorial regression analysis showed that the use of targeted drugs and T stage were independent factors of prognosis (p < 0.05) and the equation Y = 0.476 + 2.733X1 + − 0.758 × 2 (Y = efficacy, X1 = targeted drug therapy, X2 = T stage) was obtained. Then, a prognostic nomogram prediction model was constructed. The prediction model was validated internally for 1000 times using the Bootstrap resampling method with an accuracy of 79.29%. The calibration curve suggests that the predicted values fit well with the true values. The clinical decision curve (DCA) shows that the model has good clinical predictive value.

Conclusion
The use of targeted therapy significantly improved the prognosis of patients with EGFR-positive advanced NPC. For advanced NPC patients with T1 and T2 stages, IC sequenced with CCRT is more effective, and the addition of targeted therapy can further improve patients’ prognosis. For advanced NPC patients with T3 and T4 stages, IC sequenced with CCRT is ineffective, and the addition of targeted therapy can significantly improve patient prognosis.
Mediastinal large B cell lymphoma and surrounding gray areas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology
Authors: Gibson Sarah E. , Dojcinov Stefan , Dotlic Snjezana , Hartmann Sylvia , Hsi Eric D. , Klimkowska Monika , Melle Federica , Pileri Stefano A. , Ramsower Colleen A. , Rech Karen , Rimsza Lisa M. , Rodriguez-Pinilla Socorro Maria , Tousseyn Thomas A. , de Jong Daphne , Sabattini Elena 
Published: August 2023

AbstractSession 3 of the 2021 European Association for Haematopathology/Society for Hematopathology Workshop focused on mediastinal large B cell lymphomas and surrounding gray areas. One half of the session was dedicated to primary mediastinal large B cell lymphoma (PMBL) and included cases with classic clinicopathologic features, as well as cases with either morphologic or immunophenotypic variation, and PMBL-like cases with primary extramediastinal disease. The role of additional immunophenotyping and/or molecular testing to aid in the diagnosis of PMBL was discussed. The second half of the session focused on mediastinal and non-mediastinal gray zone lymphomas (GZL) with features intermediate between diffuse large B cell lymphoma (DLBCL) and classic Hodgkin lymphoma (CHL). Several cases illustrating the current challenges in separating this entity from PMBL/DLBCL and CHL were presented. There was discussion regarding the clinical and genetic differences between mediastinal and non-mediastinal GZLs. Rare cases of PMBL and GZL associated with EBV or follicular lymphoma were reviewed. Finally, several cases included in the session highlighted composite or sequential CHL and PMBL/DLBCL and/or GZL, highlighting challenges in separating such cases from GZL.
Guide curves in stochastic dynamic programming to optimize operation policies in sequential hydropower dams
Authors: Juárez Maritza Liliana Arganis , Ramírez Rosalva Mendoza , Mora Ramón Domínguez , Reséndiz Alejandro Mendoza , Esteban Rosa Valencia , De la Cruz Courtois Omar Antonio , Elizondo Eliseo Carrizosa 
Published: August 2023

AbstractThe guide curves are tools that specify rules for dam operation that allow reducing the chances of unwanted spill or deficit events. In this research, we analyzed the importance of using guide curves and penalizing the deviation of such curves by the occurrence of surplus volume, or deficit, using optimization tools on an objective function that apply stochastic dynamic programming (SDP), guide curves and reservoir operation simulation all together, to obtain and evaluate biweekly operation policies for hydropower generation purposes. The main dams of the Grijalva River were taken as a case study. The optimization tool is based on sequential decision stages (time intervals) to operate a dam system that considers the restrictions on storage volumes, defined by high and low guide curves. An objective function was considered which maximizes energy generation, it uses coefficients to penalize unwanted events of spills, deficits, and operation conditions outside the limits of the guide curves. In conjunction with the agencies that manage the system, three tests with different guide curves were defined. To analyze their sensitivity in the results (mainly events of spillage) one more test was defined for an operation rule without considering guide curves. The system behavior was simulated with the historical record, where five variables were analyzed: total spills and deficit, minimum and maximum storage, as well as the average energy generated. By using the guide curves, the occurrence of spills and deficits was avoided.
Comparison of homocitrulline and carbamylated albumin as biomarkers of carbamylation reactions in hemodialyzed patients
Authors: Lenglet Aurelie , Jaisson Stéphane , Gillery Philippe , El Balkhi Souleiman , Liabeuf Sophie , Massy Ziad A. 
Published: August 2023

AbstractTo describe the association between levels of homocitrulline (HCit) and the degree of albumin carbamylation in a cohort of hemodialyzed patients. Plasma total and protein-bound HCit concentrations in samples from hemodialyzed patients included in NICOREN trial were determined by LC–MS/MS at baseline and after 24 weeks of treatment with either sevelamer or nicotinamide. HCit concentrations at all timepoints and in both groups were positively and significantly correlated with the degree of albumin carbamylation. Plasma concentrations of total HCit, protein-bound HCit and carbamylated albumin did not decrease after 24 weeks of treatment with either sevelamer or nicotinamide. The present results demonstrate that plasma total and protein-bound HCit concentrations were closely associated with albumin carbamylation in hemodialyzed patients. Therefore, total and protein-bound HCit concentrations might be valuable biomarkers of the overall intensity of protein carbamylation in this context. Given the less complex and time-consuming analytical methods required, these markers should be favored in future clinical studies of carbamylation reaction.
A fast time domain solver for the equilibrium Dyson equation
Authors: Kaye Jason , U. R. Strand Hugo 
Published: August 2023

AbstractWe consider the numerical solution of the real-time equilibrium Dyson equation, which is used in calculations of the dynamical properties of quantum many-body systems. We show that this equation can be written as a system of coupled, nonlinear, convolutional Volterra integro-differential equations, for which the kernel depends self-consistently on the solution. As is typical in the numerical solution of Volterra-type equations, the computational bottleneck is the quadratic-scaling cost of history integration. However, the structure of the nonlinear Volterra integral operator precludes the use of standard fast algorithms. We propose a quasilinear-scaling FFT-based algorithm which respects the structure of the nonlinear integral operator. The resulting method can reach large propagation times and is thus well-suited to explore quantum many-body phenomena at low energy scales. We demonstrate the solver with two standard model systems: the Bethe graph and the Sachdev-Ye-Kitaev model.
Analysis of photospheric magnetic fields in AR 12546: a case study
Authors: Abdelkawy Ali G. A. , Shaltout Abdelrazek M. K. 
Published: August 2023

AbstractWe investigate high-resolution observations with the spectropolarimeter (SP) aboard the Hinode satellite of the Solar Optical Telescope (SOT) of a positive polarity sunspot of an active region (AR) (NOAA 12546). We present a case study for the properties of the thermal, magnetic field, and plasma flows as a function of the optical depth from the inversion of the observed Stokes profiles, covering a wide field of view area. Particular attention is paid to the examination of the net circular polarization (NCP) and area asymmetry of spectral lines in sunspots. We detect a large red-shifted velocity of 10 km sec−1 localized with the presence of a strong magnetic field corresponding to the NCP best fit of the inverted profiles. In addition, the comparison between the observed and calculated NCPs or Stokes V area asymmetries of spectral lines fitted well for most pixels in the field of view region, with a significant indication of a single-component inversion. We study the vertical gradients of temperature, magnetic strength, inclination field, and LOS velocity in the deeper and higher layers of the photosphere. The difference in the penumbral temperature between the two atmospheric layers is −130 K. The penumbral regions reveal a magnetic field gradient of $\Delta B \sim -0.5$
Δ
B
∼
−
0.5
to −0.9 G km−1. The inclination gradient in the limb-side penumbra is between $(\Delta \gamma /\Delta z) = -9 \times 10^{-3}$
(
Δ
γ
/
Δ
z
)
=
−
9
×

10

−
3

deg km−1 to $-3.5 \times 10^{-2}$
−
3.5
×

10

−
2

deg km−1. In particular, we find a higher positive inclination gradient in the disk center-side penumbra $(\Delta \gamma /\Delta z)= 0.2 - 1.5 \deg \text{ km}^{-1}$
(
Δ
γ
/
Δ
z
)
=
0.2
−
1.5
deg

km

−
1

. The velocity gradient is $(\Delta V_{LOS}/\Delta \log \tau )= -0.13$
(
Δ

V

L
O
S

/
Δ
log
τ
)
=
−
0.13
to −0.30 km sec−1 in the limb-side penumbra, and the disk center-side penumbra is given by $(\Delta V_{LOS}/\Delta \log \tau )= 0.11$
(
Δ

V

L
O
S

/
Δ
log
τ
)
=
0.11
to 0.29 km sec−1.
Biomarkers for polycyclic aromatic hydrocarbons in human excreta: recent advances in analytical techniques—a review
Authors: Styszko Katarzyna , Pamuła Justyna , Pac Agnieszka , Sochacka-Tatara Elżbieta 
Published: August 2023

AbstractPolycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants that are generated by the incomplete combustion of organic materials. The main anthropogenic sources of PAHs are the combustion of solid fuels for heating purposes, illegal waste incineration, road transport and industries based on fossil fuels. PAHs can easily enter the body because they are present in all elements of the environment, including water, soil, air, and food. Due to their ubiquitous presence, PAHs, may exert a harmful effect on human health. Assessing PAH exposure through biomonitoring mostly involve techniques to measure the concentration of 1-hydroxypyrene in human urine. Nevertheless, through recent progress in analytical techniques, other common metabolites of PAHs in human biospecimens can be detected. A scientific literature search was conducted to determine which hydroxy derivatives of PAHs are markers of PAHs exposure and to reveal the leading sources of these compounds. Techniques for analyzing biological samples to identify OH-PAHs are also discussed. The most frequently determined OH-PAH in human urine is 1-hydroxypyrene, the concentration of which reaches up to a dozen ng/L in urine. Apart from this compound, the most frequently determined biomarkers were naphthalene and fluorene metabolites. The highest concentrations of 1- and 2-hydroxynaphthalene, as well as 2-hydroxyfluorene, are associated with occupational exposure and reach approximately 30 ng/L in urine. High molecular weight PAH metabolites have been identified in only a few studies. To date, PAH metabolites in feces have been analyzed only in animal models for PAH exposure. The most frequently used analytical method is HPLC-FLD. However, compared to liquid chromatography, the LOD for gas chromatography methods is at least one order of magnitude lower. The hydroxy derivatives naphthalene and fluorene may also serve as indicators of PAH exposure.
When gold standards are not so golden: prevalence bias in randomized trials on endoscopic colorectal cancer screening
Authors: Brenner Hermann , Heisser Thomas , Cardoso Rafael , Hoffmeister Michael 
Published: August 2023

AbstractRandomized trials on the effectiveness of screening endoscopy in reducing colorectal cancer (CRC) risk have reported statistically significant, but rather modest reduction of CRC risk by the screening offer. However, risk estimates in these trials included substantial proportions of prevalent CRC cases which were early detected, but could not possibly have been prevented by screening. Thereby, a key principle of randomized prevention trials is violated that only “at risk” persons who do not yet have the disease one aims to prevent should be included in measures of preventive effects. Using recently published data from the Nordic-European Initiative on Colorectal Cancer (NordICC) trial as an example, we illustrate that approaches aimed to account for “prevalence bias” lead to effect estimates that are substantially larger than those reported in the trial and more in line with results from observational studies and real life settings. More rigorous methodological work is needed to develop effective and user-friendly tools to prevent or adjust for prevalence bias in future screening studies.
How do Autistic and Neurotypical Children’s Interests Influence their Accuracy During Novel Word Learning?
Authors: Rothwell Charlotte , Westermann Gert , Hartley Calum 
Published: August 2023

AbstractWord learning depends on attention – children must focus on the right things at the right times. However, autistic children often display restricted interests, limiting their intake of stimuli during word learning. This study investigates how category interests influence word learning in autism and neurotypical development. Autistic and neurotypical children matched on receptive vocabulary used a touch-screen computer to learn novel words associated with animals (high-interest stimuli) and objects (neutral-interest stimuli) via fast mapping. Response accuracy and speed were examined at referent selection, 5-minute retention, and 24-hour retention. Both groups identified meanings of novel words associated with unfamiliar animals and objects via mutual exclusivity with comparable accuracy. After 5 minutes, autistic children retained animal names with greater accuracy than neurotypical children. Autistic children showed a greater increase in their accuracy between 5-minute and 24-hour retention and outperformed neurotypical children across conditions after a night’s sleep. Across groups, 24-hour retention was predicted by number of target word repetitions heard at referent selection, indicating a relationship between fast mapping input and retention. However, autistic children were slower to respond correctly, particularly in the animal condition. For autistic children, superior word learning associated with high-interest stimuli was relatively short-term, as sleep appeared to consolidate their memory representations for neutral-interest stimuli. Although these results demonstrate that fundamental word learning mechanisms are not atypical in autism, slower response times may signal a speed-accuracy trade-off that could have implications for naturalistic language acquisition. Our findings also indicate favourable environmental conditions to scaffold word learning.
Pilot-scale cultivation of the red alga Porphyridium purpureum over a two-year period in a greenhouse
Authors: Schoeters Floris , Spit Jornt , Swinnen Erwin , De Cuyper Audrey , Vleugels Rut , Noyens Isabelle , Van Miert Sabine 
Published: August 2023

AbstractMicroalgae can form renewable feedstock for many sectors. However, most microalgae commercially cultivated are difficult to grow in colder climates. To overcome this problem one could cultivate cold tolerant algae. One such alga is the red marine alga Porphyridium purpureum. It is currently often cultivated in bag systems in limited volumes. In this study we cultivated P. purpureum at pilot-scale in horizontal tubular reactors in a greenhouse. P. purpureum was grown in batch mode in a total volume of either 350, 500, 1000 or 1500 L. A total of 28 batches, spread over two years, were cultivated reaching a maximum dry weight of 1.94 g L−1. The growth was continuously monitored to calculate the productivities and growth rates. The P and N concentrations were measured frequently during four batches to calculate the P and N usage per gram biomass. To calculate CO2 fixation efficiencies the total CO2 consumption was monitored during 6 of the 28 batches. A maximum productivity and growth rate of respectively 0.195 g L−1 day−1 and 0.233 day−1 were achieved while the P and N usage varied from 3.2–6.19 and 14.5–36.6 mg g−1 biomass for P and N, respectively. Growth was supported between 10 °C and 30 °C, while temperatures above 34—35 °C proved to be detrimental. The CO2 efficiencies differed among the 6 tested periods with the highest utilization efficiency being 13.5% and the lowest a mere 1.5%. Further large-scale, continuous, tests would be needed to fully optimize the cultivation of P. purpureum in larger volumes.
Targeted drug-loaded PLGA-PCL microspheres for specific and localized treatment of triple negative breast cancer
Authors: Nwazojie Chukwudalu C. , Obayemi John D. , Salifu Ali A. , Borbor-Sawyer Sandra M. , Uzonwanne Vanessa O. , Onyekanne Chinyerem E. , Akpan Udom M. , Onwudiwe Killian C. , Oparah Josephine C. , Odusanya Olushola S. , Soboyejo Winston O. 
Published: August 2023

AbstractThe paper presents the results of the experimental and analytical study of targeted drug-loaded polymer-based microspheres made from blend polymer of polylactic-co-glycolic acid and polycaprolactone (PLGA-PCL) for targeted and localized cancer drug delivery. In vitro sustained release with detailed thermodynamically driven drug release kinetics, over a period of three months using encapsulated targeted drugs (prodigiosin-EphA2 or paclitaxel-EphA2) and control drugs [Prodigiosin (PGS), and paclitaxel (PTX)] were studied. Results from in vitro study showed a sustained and localized drug release that is well-characterized by non-Fickian Korsmeyer–Peppas kinetics model over the range of temperatures of 37 °C (body temperature), 41 °C, and 44 °C (hyperthermic temperatures). The in vitro alamar blue, and flow cytometry assays in the presence of the different drug-loaded polymer formulations resulted to cell death and cytotoxicity that was evidence through cell inhibition and late apoptosis on triple negative breast cancer (TNBC) cells (MDA-MB 231). In vivo studies carried out on groups of 4-week-old athymic nude mice that were induced with subcutaneous TNBC, showed that the localized release of the EphA2-conjugated drugs was effective in complete elimination of residual tumor after local surgical resection. Finally, ex vivo histopathological analysis carried out on the euthanized mice revealed no cytotoxicity and absence of breast cancer metastases in the liver, kidney, and lungs 12 weeks after treatment. The implications of the results are then discussed for the development of encapsulated EphA2-conjugated drugs formulation in the specific targeting, localized, and sustain drug release for the elimination of local recurred TNBC tumors after surgical resection.
Graphical Abstract
Wave and current in extratropical versus tropical cyclones
Authors: Chang Yu-Chia , Chen Guan-Yu , Chu Peter C. , Centurioni Luca R. , Liu Chin-Chu 
Published: August 2023

AbstractData from QuikSCAT, ERA5, WAVERYS, drifters, and HYCOM + NCODA Reanalysis in the northern Pacific are analyzed under tropical cyclones (TCs) and extratropical cyclones (ECs). The EC (TC) has the stable (unstable) wind directions and wider (narrower) fetch resulting in a larger (smaller) significant wave height (Hs). For modest and weak wind speeds (W ≤ 26 m s−1), the current speed (U) is higher in low latitudes than in mid-latitudes since the oceanic mixed-layer thickness (ℎ) is not large enough. For strong wind speed (W > 26 m s−1), ℎ deepens more in low latitudes and causes lower U.
Assessing the Feasibility, Acceptability, and Effectiveness of a Pilot Hepatitis C Screening Program at Food Distribution Sites in Cherokee Nation, Oklahoma
Authors: Essex Whitney , Mera Jorge , Comiford Ashley , Winters Amanda , Feder Molly A 
Published: August 2023

AbstractCompared with other racial and ethnic groups in the United States, American Indian and Alaska Native (AI/AN) people experience the highest incidence of acute hepatitis c (HCV). Cherokee Nation Health Services (CNHS) implemented a pilot health screening program from January through May 2019 to assess whether conducting HCV and other preventive health screenings at food distribution sites is a feasible, acceptable, and effective strategy to increase health screening among underserved community members. Data were collected among 340 eligible participants. Most (76%) participants reported being very comfortable receiving health screenings at food distribution sites and that getting screened at food distribution sites is very easy (75.4%). Most (92.1%, n = 313) participants received HCV screening, with 11 (3.5%) individuals testing positive for HCV antibodies. Of the 11 HCV seropositive individuals, six were confirmed to have active HCV infection of which four initiated treatment. Most (55.7%) participants exhibited a body mass index in the obese range, 33.1% exhibited high hemoglobin A1C (> 6.0), 24.5% exhibited high (> 200) cholesterol, 44.6% exhibited high blood pressure ( > = 140/90), and 54.8% did not have a current primary care provider. This project demonstrated that conducting HCV and other health screenings at food distribution sites within Cherokee Nation was an effective strategy to engage AI/AN people in preventive health screenings. Future programs are needed to scale-up preventive health screenings outside of traditional medical facilities as these types of screenings may help to decrease the HCV disparities among AI/AN people.