bluuebunny/crossref_metadata_2025_split huggingface dataset:
1,2,3-Triazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones and 6,7-Dihydrobenzo[d]isoxazol-4(5H)-ones: Synthesis and Biological Activity
Authors: Khlebniсova T. S. , Zinovich V. G. , Piven Yu. A. , Baranovsky A. V. , Lakhvich F. A. , Trifonov R. E. , Golubeva Yu. A. , Klyushova L. S. , Lider E. V. 
Published: March 2023

Abstract
Triazole-containing 1,5,6,7-tetrahydro-4H-indazol-4-ones and 6,7-dihydrobenzo[d]isoxazol-4(5H)-ones were synthesized by cyclocondensation of 2-[(1H-1,2,3-triazol-1-yl)acetyl]cyclohexane-1,3-diones with phenylhydrazine (4-fluorophenylhydrazine) or hydroxylamine, respectively. Structure and composition of the obtained compounds were confirmed by 1H, 13C, 19F NMR spectroscopy methods and by data of elemental analysis. Cytotoxic and cytostatic activities of the series of obtained compounds were investigated in vitro against human hepatocellular carcinoma cells HepG2, mammary adenocarcinoma cells MCF-7, and laryngeal cancer cells Hep2.
Fragility and resilience: parental and family perspectives on the impacts of extreme prematurity
Authors: Janvier Annie , Bourque Claude Julie , Pearce Rebecca , Thivierge Emilie , Duquette Laurie-Anne , Jaworski Magdalena , Barrington Keith J , Synnes Anne R , Church Paige , Luu Thuy Mai 
Published: March 2023

ObjectivesExtremely preterm babies have a significant risk of neurodevelopmental impairment (NDI). There has been little investigation regarding the impact of prematurity on families. The objective of this study was to explore parental perspectives regarding the impact of prematurity on themselves/their family.MethodsOver 1 year, parents of children born <29 weeks’ gestational age (GA) who were between 18 months old and 7 years old and came for their follow-up visit were invited to participate. They were asked to categorise the impacts of prematurity on their life and their family as positive, negative or both and to describe those impacts in their own words. Thematic analysis was performed by a multidisciplinary group, including parents. Logistic regression was performed to compare parental responses.ResultsAmong parents (n=248, 98% participation rate), most (74%) reported that their child’s prematurity had both positive and negative impacts on their life or their family’s life, while 18% reported only positive impacts and 8% only negative impacts. These proportions were not correlated with GA, brain injury, nor level of NDI. The positive impacts reported included: an improved outlook on life, such as gratitude and perspective (48%), stronger family relationships (31%) and the gift of the child (28%). The negative themes were stress and fear (42%), loss of equilibrium due to medical fragility (35%) and concerns about developmental outcomes including the child’s future (18%).ConclusionParents report both positive and negative impacts after an extremely preterm birth, independent of disability. These balanced perspectives should be included in neonatal research, clinical care and provider education.
Piece of Mind: Presenting the Lived Experience and Scientific Research of Parkinson’s Disease through an Artistic Lens
Authors: Kuhlmann Naila , Robert Jérémie , Thomas Aliki , Blain-Moraes Stefanie 
Published: March 2023

Abstract
Many of the important research advances in understanding and treating Parkinson’s disease never leave the academic sphere, as communication barriers limit accessibility for, and engagement with, broader audiences. To increase meaningful dialogue between academic researchers and community stakeholders, Piece of Mind: Parkinson’s brought together neuroscientists, people with Parkinson’s disease (PD), and artists to co-create a knowledge translation performance based on scientific research and lived experience. The filmed, feature-length performance engages the viewer emotionally and intellectually using circus, dance, music, poetry, and patient testimonials. We provide an overview of our participatory process and a scene-by-scene description of the performance.
The Prospect of Art-Science Interplay in Filmmaking as Research: From Abstract to Implicit Film
Authors: Afdile Mamdooh 
Published: March 2023

Abstract
The neuroscientific and psychological use of fiction films for clinical and academic research is growing. However, artistic research using insights from these fields to advance the filmmaking practice is still in its infancy. Expanding on the author’s previous Leonardo publication proposing the use of scientific hypothesis formation for overcoming filmmaking uncertainty, this artistic research explores the feasibility of integrating scientific findings of abstract and ambiguous image perception to create a novel abstract filmmaking method. This research aims to revive the classical abstract film genre into an implicit cinematic experience.
Crescas and Gersonides on Freedom, Astrology, and Divine Omniscience
Authors: Green Alexander 
Published: March 2023

Abstract
Crescas’s position on human freedom is dialectically rooted in the philosophy of his medieval predecessor, Gersonides. Crescas accepts Gersonides’s view that although the celestial bodies influence human affairs, human beings have the ability to overcome their predetermined fate. However, Crescas rejects Gersonides’s premise that God only knows the universal aspect of the particular. Crescas contends that God’s commandments give their followers the means to obtain freedom from the effects of the heavenly bodies, without denying that practical deliberation is still required in order to actualize God’s promises, even if God knows how the individual will achieve the promised outcome.
Diplomatic Peace
Authors: Kornprobst Markus 
Published: March 2023

Summary
This article introduces the concept of diplomatic peace. It starts by developing a heuristic frame for identifying understandings of peace embraced by the actors we study. This frame encompasses three faces of peace — restraint, compromise and polylogue — and further differentiates different degrees of each of these faces (induced, co-operative and categorical restraint; profitable, principled and iterated compromise; extended, communal and deliberative polylogue). Then, this heuristic is applied to key United Nations General Assembly declarations and conventions that have passed unanimously since 1946. Studying how diplomats define peace yields remarkable results. Diplomats make far-reaching promises about the kind of peace they purport to pursue, strongly endorsing co-operative restraint, principled compromises and deliberative polylogues. The added value of this article is threefold: it systematically enquires into the nexus of diplomacy and peace, develops a multifaceted concept of peace, and reminds scholars and practitioners of how far-reaching already existing diplomatic promises of peace are.
A new species of Xeroderus Gray, 1835 (Phasmida: Phasmatidae: Xeroderinae) from Papua New Guinea and notes on the genus
Authors: BROCK PAUL D. , HENNEMANN FRANK H. 
Published: March 2023

Studies on the genus Xeroderus have revealed a new species from Papua New Guinea: Xeroderus conlei sp. n., which is described and figured from the holotype female only. Keys are provided to compare it with X. kirbyi Gray, 1835 from Australia, the only other species in the genus. Lectotypes are designated for X. kirbyi and the synonym Cooktownia plana Sjöstedt, 1918. Xeroderus brevipennis Redtenbacher, 1908 is found to be a member of Nisyrus Stål, 1877 and is here removed from Xeroderus and transferred to Nisyrus Stål, 1877. N. brevipennis (Redtenbacher, 1908) comb. n. is the first record of Nisyrus from the Solomon Islands. Various additional Australian localities are recorded for X. kirbyi Gray, 1835.
Role of plasma fibrinogen and D-dimer as prognostic biomarkers in patients with non-muscle invasive bladder cancer
Authors: Singla Sahil , Goel Apul , Mishra Sanjay , Lohani Ravi , Sankhwar Satya Narayan , Singh Sashi Raj 
Published: March 2023

Abstract
Background
We aimed to evaluate the role of plasma fibrinogen and D-dimer as prognostic biomarkers in patients with non-muscle invasive bladder cancer (NMIBC).

Methods
The prospective study included 35 patients (30 males) with newly diagnosed NMIBC with no history of thromboembolic event or anti-coagulant intake or active infection and underwent complete trans-urethral resection between September 2020 and December 2021. Patients with deranged hepato-renal functions, refractory hypertension or diagnosed with COVID-19 infection with in one-month before surgery or routine follow-up were excluded. Follow-up was done as per NCCN guidelines. Fibrinogen and D-dimer levels were measured with in seven days of surgery or follow-up and analyzed for recurrence-free survival (RFS) and progression-free survival (PFS). Cox regression analyses were adopted to assess the influence of these two parameters on RFS and PFS.

Results
The mean age was 53.9 years with a median follow-up of 9-months. Nine had recurrence of which six had progression. The cut-off values of fibrinogen and D-dimer were 402.5 mg/dl and 0.55 µg/ml, respectively. Kaplan–Meier analysis demonstrated that high fibrinogen and D-dimer levels were significantly related to poor RFS and PFS (p < 0.001). On multivariate analysis only fibrinogen and D-dimer retained their significance for RFS (p = 0.026 and 0.014, respectively) and PFS (p = 0.027 and 0.042, respectively). High levels of fibrinogen and D-dimer were also present in patients who had recurrence or progression at follow-up visits compared to rest of the patients.

Conclusions
High levels of fibrinogen and D-dimer may indicate worse prognosis in patients with NMIBC, suggesting that these two can be used as prognostic biomarkers.
Effects of OsomeFood Clean Label plant-based meals on the gut microbiome
Authors: Jacky Dwiyanto , Bibi Chia , Meng Look Melvin Chee , Jason Fong , Gwendoline Tan , Jeremy Lim , Wie Chong Chun 
Published: March 2023

Abstract
Background
Plant-based diets offer more beneficial microbes and can modulate gut microbiomes to improve human health. We evaluated the effects of the plant-based OsomeFood Clean Label meal range (‘AWE’ diet), on the human gut microbiome.

Methods
Over 21 days, ten healthy participants consumed OsomeFood meals for five consecutive weekday lunches and dinners and resumed their regular diets for other days/meals. On follow-up days, participants completed questionnaires to record satiety, energy and health, and provided stool samples. To document microbiome variations and identify associations, species and functional pathway annotations were analyzed by shotgun sequencing. Shannon diversity and regular diet calorie intake subsets were also assessed.

Results
Overweight participants gained more species and functional pathway diversity than normal BMI participants. Nineteen disease-associated species were suppressed in moderate-responders without gaining diversity, and in strong-responders with diversity gains along with health-associated species. All participants reported improved short-chain fatty acids production, insulin and γ-aminobutyric acid signaling. Moreover, fullness correlated positively with Bacteroides eggerthii; energetic status with B. uniformis, B. longum, Phascolarctobacterium succinatutens, and Eubacterium eligens; healthy status with Faecalibacterium prausnitzii, Prevotella CAG 5226, Roseburia hominis, and Roseburia sp. CAG 182; and overall response with E. eligens and Corprococcus eutactus. Fiber consumption was negatively associated with pathogenic species.

Conclusion
Although the AWE diet was consumed for only five days a week, all participants, especially overweight ones, experienced improved fullness, health status, energy and overall responses. The AWE diet benefits all individuals, especially those of higher BMI or low-fiber consumption.
Hypotension prediction index guided versus conventional goal directed therapy to reduce intraoperative hypotension during thoracic surgery: a randomized trial
Authors: Šribar Andrej , Jurinjak Irena Sokolović , Almahariq Hani , Bandić Ivan , Matošević Jelena , Pejić Josip , Peršec Jasminka 
Published: March 2023

Abstract
Purpose
Intraoperative hypotension is linked to increased incidence of perioperative adverse events such as myocardial and cerebrovascular infarction and acute kidney injury. Hypotension prediction index (HPI) is a novel machine learning guided algorithm which can predict hypotensive events using high fidelity analysis of pulse-wave contour. Goal of this trial is to determine whether use of HPI can reduce the number and duration of hypotensive events in patients undergoing major thoracic procedures.

Methods
Thirty four patients undergoing esophageal or lung resection were randomized into 2 groups -“machine learning algorithm” (AcumenIQ) and “conventional pulse contour analysis” (Flotrac). Analyzed variables were occurrence, severity and duration of hypotensive events (defined as a period of at least one minute of MAP below 65 mmHg), hemodynamic parameters at 9 different timepoints interesting from a hemodynamics viewpoint and laboratory (serum lactate levels, arterial blood gas) and clinical outcomes (duration of mechanical ventilation, ICU and hospital stay, occurrence of adverse events and in-hospital and 28-day mortality).

Results
Patients in the AcumenIQ group had significantly lower area below the hypotensive threshold (AUT, 2 vs 16.7 mmHg x minutes) and time-weighted AUT (TWA, 0.01 vs 0.08 mmHg). Also, there were less patients with hypotensive events and cumulative duration of hypotension in the AcumenIQ group. No significant difference between groups was found in terms of laboratory and clinical outcomes.

Conclusions
Hemodynamic optimization guided by machine learning algorithm leads to a significant decrease in number and duration of hypotensive events compared to traditional goal directed therapy using pulse-contour analysis hemodynamic monitoring in patients undergoing major thoracic procedures. Further, larger studies are needed to determine true clinical utility of HPI guided hemodynamic monitoring.

Trial registration
Date of first registration: 14/11/2022
Registration number: 04729481-3a96-4763-a9d5-23fc45fb722d
RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity
Authors: Barua David , Sultana Afrin , Islam Md Nahidul , Cox Fergus , Gupta Ananya , Gupta Sanjeev 
Published: March 2023

AbstractBackgroundEndocrine-resistant breast cancers have elevated expression of XBP1, where it drives endocrine resistance by controlling the expression of its target genes. Despite the in-depth understanding of the biological functions of XBP1 in ER-positive breast cancer, effectors of endocrine resistance downstream of XBP1 are poorly understood. The aim of this study was to identify the XBP1-regulated genes contributing to endocrine resistance in breast cancer.MethodsXBP1 deficient sub-clones in MCF7 cells were generated using the CRISPR-Cas9 gene knockout strategy and were validated using western blot and RT-PCR. Cell viability and cell proliferation were evaluated using the MTS assay and colony formation assay, respectively. Cell death and cell cycle analysis were determined using flow cytometry. Transcriptomic data was analysed to identify XBP1-regulated targets and differential expression of target genes was evaluated using western blot and qRT-PCR. Lentivirus and retrovirus transfection were used to generate RRM2 and CDC6 overexpressing clones, respectively. The prognostic value of the XBP1-gene signature was analysed using Kaplan–Meier survival analysis.ResultsDeletion of XBP1 compromised the upregulation of UPR-target genes during conditions of endoplasmic reticulum (EnR) stress and sensitized cells to EnR stress-induced cell death. Loss of XBP1 in MCF7 cells decreased cell growth, attenuated the induction of estrogen-responsive genes and sensitized them to anti-estrogen agents. The expression of cell cycle associated genes RRM2, CDC6, and TOP2A was significantly reduced upon XBP1 deletion/inhibition in several ER-positive breast cancer cells. Expression of RRM2, CDC6, and TOP2A was increased upon estrogen stimulation and in cells harbouring point-mutants (Y537S, D538G) of ESR1 in steroid free conditions. Ectopic expression of RRM2 and CDC6 increased cell growth and reversed the hypersensitivity of XBP1 KO cells towards tamoxifen conferring endocrine resistance. Importantly, increased expression of XBP1-gene signature was associated with poor outcome and reduced efficacy of tamoxifen treatment in ER-positive breast cancer.ConclusionsOur results suggest that RRM2 and CDC6 downstream of XBP1 contribute to endocrine resistance in ER-positive breast cancer. XBP1-gene signature is associated with poor outcome and response to tamoxifen in ER-positive breast cancer.
Caregiver, secondary victim: outcome of caring for patients with COVID -19: a qualitative content analysis study
Authors: Faghani Safieh , Ahmadi Fazlollah , Mohammadi Eesa 
Published: March 2023

Abstract
Background
Considering the importance of caring for patients with COVID -19 at home and the majority of care being the responsibility of family caregivers, it is necessary to identify and assess the problems during the implementation of patient care in family caregivers. Therefore, the present study was conducted to discover the different consequences of caring for patients with COVID-19 in family caregivers.

Method
Using Purposive sampling, 15 female family caregivers were included in the study. This study was conducted between 2021 and 2022 in Iran. Unstructured face-to-face and virtual interviews were used to collect data until data saturation was reached. Data were analyzed through Granheim and Lundman conventional content analysis approach.

Results
The analysis of data related to the outcome of caring for patients with COVID -19 in family caregivers, led to the extraction of six subcategories: " caregivers experiencing physical symptoms ", "perception of extra pressure and psychological symptoms in the caregiver", "disruption in marital relations", "feeling of homelessness and rejection" and " role pressure due to lack of family support". The subcategories led to the development of the main category "caregiver, the secondary victim", which is experienced by family caregivers during the provision of care for patients with COVID -19.

Conclusion
Family caregivers experience high levels of negative consequences from providing care to patients with COVID-19. Therefore, more attention should be paid to all dimensions of caregiver health such as physical, mental, and marital to provide quality care to patients finally.
The effect of ambient ozone exposure on three types of diabetes: a meta-analysis
Authors: Yu Sirui , Zhang Mingzhi , Zhu Jiamin , Yang Xu , Bigambo Francis Manyori , Snijders Antoine M. , Wang Xu , Hu Weiyue , Lv Wei , Xia Yankai 
Published: March 2023

Abstract
Background
Ozone as an air pollutant is gradually becoming a threat to people's health. However, the effect of ozone exposure on risk of developing diabetes, a fast-growing global metabolic disease, remains controversial.

Objective
To evaluate the impact of ambient ozone exposure on the incidence rate of type 1, type 2 and gestational diabetes mellitus.

Method
We systematically searched PubMed, Web of Science, and Cochrane Library databases before July 9, 2022, to determine relevant literature. Data were extracted after quality evaluation according to the Newcastle Ottawa Scale (NOS) and the agency for healthcare research and quality (AHRQ) standards, and a meta-analysis was used to evaluate the correlation between ozone exposure and type 1 diabetes mellitus (T1D), type 2 diabetes mellitus (T2D), and gestational diabetes mellitus (GDM). The heterogeneity test, sensitivity analysis, and publication bias were performed using Stata 16.0.

Results
Our search identified 667 studies from three databases, 19 of which were included in our analysis after removing duplicate and ineligible studies. Among the remaining studies, three were on T1D, five were on T2D, and eleven were on GDM. The result showed that ozone exposure was positively correlated with T2D [effect size (ES) = 1.06, 95% CI: 1.02, 1.11] and GDM [pooled odds ratio (OR) = 1.01, 95% CI: 1.00, 1.03]. Subgroup analysis demonstrated that ozone exposure in the first trimester of pregnancy might raise the risk of GDM. However, no significant association was observed between ozone exposure and T1D.

Conclusion
Long-term exposure to ozone may increase the risk of T2D, and daily ozone exposure during pregnancy was a hazard factor for developing GDM. Decreasing ambient ozone pollution may reduce the burden of both diseases.
CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
Authors: Thieme Elana , Bruss Nur , Sun Duanchen , Dominguez Edward C. , Coleman Daniel , Liu Tingting , Roleder Carly , Martinez Melissa , Garcia-Mansfield Krystine , Ball Brian , Pirrotte Patrick , Wang Lili , Xia Zheng , Danilov Alexey V. 
Published: March 2023

AbstractDiffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, necessitating development of novel therapeutic approaches. Pharmacological inhibitors of cyclin-dependent kinases (CDK) demonstrated pre-clinical activity in DLBCL, however many stalled in clinical development. Here we show that AZD4573, a selective inhibitor of CDK9, restricted growth of DLBCL cells. CDK9 inhibition (CDK9i) resulted in rapid changes in the transcriptome and proteome, with downmodulation of multiple oncoproteins (eg, MYC, Mcl-1, JunB, PIM3) and deregulation of phosphoinotiside-3 kinase (PI3K) and senescence pathways. Following initial transcriptional repression due to RNAPII pausing, we observed transcriptional recovery of several oncogenes, including MYC and PIM3. ATAC-Seq and ChIP-Seq experiments revealed that CDK9i induced epigenetic remodeling with bi-directional changes in chromatin accessibility, suppressed promoter activation and led to sustained reprograming of the super-enhancer landscape. A CRISPR library screen suggested that SE-associated genes in the Mediator complex, as well as AKT1, confer resistance to CDK9i. Consistent with this, sgRNA-mediated knockout of MED12 sensitized cells to CDK9i. Informed by our mechanistic findings, we combined AZD4573 with either PIM kinase or PI3K inhibitors. Both combinations decreased proliferation and induced apoptosis in DLBCL and primary lymphoma cells in vitro as well as resulted in delayed tumor progression and extended survival of mice xenografted with DLBCL in vivo. Thus, CDK9i induces reprogramming of the epigenetic landscape, and super-enhancer driven recovery of select oncogenes may contribute to resistance to CDK9i. PIM and PI3K represent potential targets to circumvent resistance to CDK9i in the heterogeneous landscape of DLBCL.
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
Authors: Raju Ganji Seeta Rama , Pavitra Eluri , Bandaru Sai Samyuktha , Varaprasad Ganji Lakshmi , Nagaraju Ganji Purnachandra , Malla Rama Rao , Huh Yun Suk , Han Young-Kyu 
Published: March 2023

AbstractHOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated with the tumor grade and prognosis of a variety of carcinomas including breast cancer (BC). HOTAIR regulates various target genes via sponging and epigenetic mechanisms and controls various oncogenic cellular and signaling mechanisms including metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by a variety of transcriptional and epigenetic mechanisms. In this review, we describe the regulatory mechanisms that govern HOTAIR expression during cancer development and explore how HOTAIR drives BC development, metastasis, and drug resistance. In the final section of this review, we focus on the role of HOTAIR in BC management, therapeutic treatment, and prognosis, highlighting its potential therapeutic applications.