bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forebrain neural progenitors effectively integrate into host brain circuits and improve neural function after ischemic stroke
Authors: He Xiao , Chen Jiadong , Zhong Yan , Cen Peili , Shen Li , Huang Fei , Wang Jing , Jin Chentao , Zhou Rui , Zhang Xiaohui , Wu Shuang , Tu Mengjiao , Qin Xiyi , Luo Xiaoyun , Zhou Yu , Peng Jieqiao , Zhou Youyou , Civelek A. , Tian Mei , Zhang Hong 
Published: September 2023

Abstract
Human neural progenitor cell transplantation shows great potential in stroke treatment by replacing lost cortical neurons and repairing damaged brain circuits. However, the commonly utilized human neural progenitors fail to yield a substantial proportion of diverse cortical neurons and require an extended period to achieve synaptic integration, thereby diminishing the optimal benefits of cell transplantation for stroke. Here, we generated forkhead box G1 (FOXG1)-positive forebrain progenitors from human inducible pluripotent stem cells, which can differentiate into various cortical neurons including upper- and deep-layer excitatory and inhibitory neurons, achieving early functional maturation simultaneously in vitro. Furthermore, these FOXG1 forebrain progenitor cells achieved robust cortical neuronal differentiation, rapid functional maturation and efficient synaptic integration after transplantation into the sensory cortex of stroke-injured adult rats. Notably, we have successfully utilized the non-invasive 18F-SynVesT-1 PET imaging technique to assess alterations in synapse count before and after transplantation therapy of FOXG1 progenitors in vivo for the first time. Moreover, the transplanted FOXG1 progenitors improved fine motor behavior and prevented the onset of chronic post-stroke seizures. These findings provide systematic and compelling evidence for the suitability of these FOXG1 progenitors for neuronal replacement in ischemic cortical stroke.
Single-Cell and Transcriptomic Analyses Reveal the Influence of Diabetes on Ovarian Cancer
Authors: Zhao Zhihao , Wang Qilin , Zhao Fang , Ma Junnan , Sui Xue , Choe Hyok Chol , Chen Peng , Li Siqi , Zhang Lin 
Published: September 2023

Abstract
Background:There has been a significant surge in the global prevalence of diabetes mellitus (DM), which increases the susceptibility of individuals to ovarian cancer (OC). However, the relationship between DM and OC remains largely unexplored. The objective of this study is to provide preliminary insights into the shared molecular regulatory mechanisms and potential biomarkers between DM and OC.
Methods:Multiple datasets from the GEO database were utilized for bioinformatics analysis. Single cell datasets GSE184880 and GSE165816 from the GEO database were analysed. Subsequently, immune cell infiltration analysis was performed on mRNA expression data from GSE40595 and GSE29142. The intersection of these datasets yielded a set of common genes associated with both OC and DM. Using these overlapping genes and Cytoscape, a protein‒protein interaction (PPI) network was constructed, and 10 core targets were selected. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were then conducted on these core targets. Additionally, advanced bioinformatics analyses, including transcription factor (TF)–genes interaction network analysis and microRNA (miRNA)–genes coregulation network analysis, were performed based on the core targets.
Results:Immune cell infiltration analysis of mRNA expression data revealed significant differences in mononuclear cell levels. By intersecting the single-cell datasets, a total of 119 targets related to mononuclear cells in both OC and DM were identified. PPI network analysis further identified 10 hub genesincludingHSP90AA1, HSPA8, SNRPD2, UBA52, SOD1, RPL13A, RPSA, ITGAM, PPP1CC, and PSMA5, as potential targets of OC and DM. Enrichment analysis indicated that these genes are primarily associated with neutrophil degranulation, GDP-dissociation inhibitor activity, and the IL-17 signaling pathway, suggesting their involvement in the regulation of the tumor microenvironment. Furthermore, the TF-gene and miRNA-gene regulatory networks were validated using NetworkAnalyst. The identified TFs included SREBF2, GATA2, and SRF, while the miRNAs included miR-320a, miR-378a-3p, and miR-26a-5p.
Conclusion: This study revealed the shared gene interaction network between OC and DM and predicted the TFs and miRNAs associated with core genes in monocytes. Our research findings contribute to identifying potential biological mechanisms underlying the relationship between OC and DM.
Comparison of intravenous nabuphine and dexmedetomidine in combination with lidocaine aerosol inhalation in awake direct laryngoscopy: a randomized, double-blind, placebo-controlled trial
Authors: Li Xingxing , Xie Cuiyu , Zhong Weiwei , Lu Yao , Li Yuanhai 
Published: September 2023

Abstract

Background: The airway should be thoroughly and accurately evaluated before anesthesia induction and endotracheal intubation. The awake direct laryngoscopy(ADL) is an important tool for assessing airway especially difficult airway, sometimes eliminates the need for fiberoptic intubation in some suspicious difficult airway cases. However, an optimal regimen has not been determined.
Aims: This study aimed to assess and compare the tolerance, satisfaction and safety of nalbuphine and dexmedetomidine combined with lidocaine for ADL.
Methods: In this double-blind, controlled study, prior to ADL, 60 patients scheduled for general anesthesia were randomly allocatedto receive 0.75μg/kg of Dex (Dex group, n = 20), 0.15 mg/kg of nalbuphine (Nal group, n = 20), or a placebo (control group, n = 20) intravenously for 10 minutes. At the same time, all study subjects received atomized lidocaine for 15 minutes.The primary outcome was patient tolerance as assessed by a 5-point ADL comfort score, while secondary outcomes included satisfaction, coughing, pain, nausea and vital signs.
Results: Patients undergoing ADL in the Nal group had higher tolerance scores than those in the control and Dex groups (P<0.01 andP<0.001, respectively) andhigher satisfaction (P<0.01 andP<0.001, respectively). Additionally, the Nal group had significantly fewer adverse events, such as nausea, coughing, and pain, than the control and Dex groups. The sedation score and peripheral oxygen and saturation was significantly higher in the Nal group than in the Dex group, with no difference between the Nal and control groups (P< 0.001, P =0.159, respectively).
Conclusions: Intravenous nabuphine in combination with lidocaine aerosol inhalation significantly improved patient tolerance and satisfaction while reducing nausea, coughing, pain, sedation and hypoxemia during ADL.
Trial registration: ChiCTR2200062116, 23/07/2022.
Oxy-fuel and air atmosphere combustions of Zingiber officinalis biomass residues: Performances, dynamics, flue gas emissions, mechanisms, and ash properties
Authors: Zhang Xiaogang , Jia Dajie , Song Shuxiang , Yang Ruzhu , Evrendilek Fatih , Zeng Wu , Li Yaohuang , Dong Shuyu , liu jingyong 
Published: September 2023

Abstract
This study aimed to turn a better understanding of the combustion dynamics of ginger (Zb) residues into operationally optimal conditions. Thermogravimetric analysis revealed that the primary degradation range of Zb was between 144–432 °C. Under the same heating rate, the N2/O2 atmosphere was more favorable for the Zb combustion than was the CO2/O2 atmosphere. The emissions of functional groups in both atmospheres remained similar and mostly occurred between 150 and 550 °C. Based on the multi-objective optimization of the best-fit neural networks, the maximum energetic performance and minimum gas emissions consistently occurred in the range of 575-1000 ℃ in the CO2/O2 atmosphere. The propensity for slagging and scaling was significantly higher in the N2/O2 atmosphere than in the CO2/O2 atmosphere. The Zb ash exhibited higher alkalinity due to the presence of alkali metals, a lower melting temperature, and other characteristics associated with slagging. The combustion in both atmospheres followed a stochastic nucleation mechanism, suggesting high reactivity of the reaction system and positive and favorable progression of the reaction. This study provides valuable insights into the operationally optimal combustion dynamics of Zb, shedding light on how to best control and valorize its gas-to-ash byproducts.
Earthworm-assisted Bioremediation in a Clayey Soil Contaminated by Biodiesel.
Authors: Immich Gabriel , Visentin Caroline , Braun Adeli Beatriz , Reginatto Cleomar , Thomé Antônio 
Published: September 2023

Abstract
The Success in bioremediation techniques depends on factors such as site characteristics, environmental factors, contaminant nature (temperature, pH, nutrients), presence of suitable biodegradable genes, the contamination nature, etc. Earthworms can aid in these on these factors, through their biological, chemical and physical characteristics, they aerate the soil, improve the nutritional status and help to release the contaminants binding in the soil particles, besides, they help the degrading microorganisms’ dispersion. Biodiesel is a contaminant widely used in the fuel industry, and its production is encouraged. Thus, the aim of this study is analyzed the efficiency of an earthworm species (Eudrilus eugeniae) to remediated a residual clayey soil contaminated with biodiesel, with and without assistance for biostimulated native microorganisms. Therefore, a clay soil was contaminated with biodiesel (24 g / kg) and the ability of the earthworms of the species (Eudrilus eugeniae) to degrade biodiesel with or without biostimulation (cattle manure) for a period of 90 days was analyzed. Earthworms and cow dung have proved to be efficient for remediation processes. Providing 100% degradation at the end of 90 days for "biostimulation and earthworm" and "biostimulation, microorganisms and earthworm" samples. Thus, the use of earthworms contributes to a faster remediation process and, together with microorganisms, they are a more sustainable solution for application in areas contaminated with fuels.
Unveiling the Multifaceted Associations between Work, Psychosocial Risks, and Musculoskeletal Disorders in the Italian workforce
Authors: Tecco Cristina Di , Adamo Giovanna , Russo Fabrizio , Iavicoli Sergio 
Published: September 2023

Abstract

Background
Musculoskeletal diseases (MSDs) pose a significant occupational health challenge and are the leading cause of disability worldwide. These conditions can adversely affect health, quality of life, productivity and result in substantial social and public costs. Psychosocial risk factors have been identified as having a causal link or worsening various MSDs. Given the advancements in technology and digitalization that may lead to new work tasks and organizational changes, MSDs and psychosocial risks have become top priorities for Occupational Safety and Health (OSH) initiatives. This study investigates the association between occupational characteristics, exposure to work-related psychosocial risks, and MSDs in a large cohort of Italian workers.
Methods:
The study draws upon data from a cross-sectional national survey, INSuLa-2, conducted in 2019 by the Italian Workers' Compensation Authority (INAIL). The survey involved 8,000 Italian workers, representing the national workforce population. The data analysis focused on variables related to psychosocial risks and MSDs, encompassing sociodemographic and occupational characteristics, psychosocial risks, and health-related aspects.
Results:
The study population had a mean age of 43.3 ± 11.5 years, with a majority of males (55.5%). The manufacturing/primary industry/mining/utilities sector was the most prevalent occupational sector (25.0%), with blue-collar workers (46.2%) and employees (43.1%) being the most common occupational groups. Participants reported a high prevalence of psychosocial risks, including elevated levels of violence and harassment (43.0%) and job insecurity (44.4%). Among MSDs, back pain was the most prevalent (45.3%), followed by shoulder, neck, and/or upper limb pain (39.4%), and lower limb pain (32.1%). Age, female gender, low educational level, and a BMI higher than 30 were identified as significant risk factors for experiencing MSDs. Occupational sectors with higher risks of MSDs included agriculture, fishing, hunting, healthcare, and social assistance. Furthermore, blue-collar workers were found to have a higher likelihood of experiencing MSDs compared to employees.
Conclusion:
This study provides insights into the association between occupational characteristics, psychosocial risk factors, and MSDs in a substantial cohort of Italian workers. The findings suggest that workers exposed to psychosocial risks in the workplace face an increased risk of MSDs. Consequently, the prevention of MSDs and psychosocial risks should be integrated into workplace health and safety programs to enhance employee health, well-being, and productivity.
Long-term outcomes by bone marrow B-cell depletion from the R2W trial of bortezomib with cyclophosphamide and rituximab in Waldenstrőm macroglobulinaemia
Authors: Auer Rebecca , de Tute Ruth , Counsell Nicholas , Clifton-Hadley Laura , D'Sa Shirley , Pratt Guy , Campbell Gavin , Campbell Lauren , Sadler Ross , Townsend William , Popova Bilyana , Smith Paul , Schofield Oliver , Owen Roger 
Published: September 2023

Abstract
There remains a lack of consensus as to the most appropriate primary therapy in Waldenstrőm macroglobulinemia (WM). We evaluated a novel bortezomib-based combination and developed a sensitive WM-specific flow cytometry assay (limit of detection 0.004% of leucocytes) to assess bone marrow (BM) response. Sixty treatment-naïve WM patients were enrolled into this phase II trial and randomised (2:1) to receive cyclophosphamide and rituximab with either bortezomib (BCR) or fludarabine (FCR). The primary objective was to assess the overall response rate (ORR) in eligible patients receiving BCR (N=41). An ORR of 97.6% (95%CI: 87.1-99.9) was observed; 27 (65.9%) patients remain alive without progression after 62.6 months median follow-up, with 2- and 3-year progression-free survival (PFS) rates of 92.7% (95%CI: 79.0-97.6) and 80.5% (95%CI: 64.8-89.7). Persistent WM B-cells were demonstrable in 19/38 patients at the end of treatment (median 0.24%, range 0.02-11.2%). PFS was markedly longer in patients with BM B-cell depletion (<0.004%) compared to those who had persistent BM B-cells detectable at end of treatment (HR=0.06, 95%CI:0.01-0.47, p<0.001), and remained independently associated after adjusting for baseline risk stratification or investigator-assessed response. BCR is a tolerable, highly efficacious regimen for treatment-naïve WM patients. BM B-cell depletion is independently associated with patient outcomes.
Can nonfinancial disclosure (NFD) benefit companies? - Evidence from the 2016 Hong Kong “Comply or Explain” mandatory environmental, social, and governance (ESG) disclosure policy
Authors: Xu Juan , Kaneko Shinji , Goto Daisaku 
Published: September 2023

Abstract
This empirical study investigates whether mandatory nonfinancial disclosure (NFD) impacts financial performance using the Hong Kong 2016 “Comply or Explain” mandatory ESG disclosure policy. We use a total of 4712 observations from balanced panel data obtained from combined sources: Refinitiv and manually collected databases from 2013 to 2020. We employ the difference-in-difference (DID) as an identification strategy to explore the average treatment effect on the treated (ATET) of mandatory ESG disclosure policy. The treatment group is dual-listed companies (A/H shares) from Hong Kong, and the control group is domestic-list-only companies (A shares) from Mainland China. The results suggest that a mandatory ESG disclosure policy positively affects corporate financial performance (Tobin’s Q). From heterogeneity analysis, we also find that mandatory disclosure varies across ownership status, economic development regions and industrial sectors. We find that Hong Kong’s 2016 "Comply or Explain" mandatory ESG disclosure policy positively impacts corporate financial performance. Our findings demonstrate the effectiveness of regulatory-driven nonfinancial information disclosure on corporate financial performance.
Carefix hexaxial spatial frame versus Ilizarov circular external fixator in treating high-energy tibial shaft fractures：a retrospective study
Authors: Zhao Zhiming , Chen Xu , Guo Feng , Liu Yabin , Shi Bowen , Ji Guoqi , Cai Chengkuo , Shu Hengsheng 
Published: September 2023

Abstract
Background: External fixation has become an effective technique for treating the high-energy tibial shaft fractures (HETSFs) , which is usually accompanied by significant surrounding soft tissue damage. This study aimed to explore the differences of clinical outcomes of HETSFs with the treatment of Carefix hexaxial spatial frame (CHSF) or Ilizarov circular external fixator (ICEF).
Methods: 46 patients suffering HETSFs that were treated between January 2019 and July 2022 by CHSF or ICEF were divided into two groups: CHSF group and ICEF group. There were 38 males and 8 females with age range of 20 to 65 years. The characteristics data, operation time, external fixation time, bone union time, final radiological outcomes, complications and clinical outcomes were recorded. The minimum follow-up was 12 months.The clinical outcomes were evaluated by the Association for the Study and Application of the Method of Ilizarov criteria (ASAMI) at the final follow-up.
Results: 46 patients with HETSFs were evaluated, including 26 patients in CHSF group and 20 patients in ICEF group in this study. The mean operation time in CHSF group (85.9±11.5 min) was shorter than that in ICEF group (95.8±4.2 min) (P<0.001). All patients achieved complete bone union. Mean external fixation time was (26.0±3.8) weeks for CHSF group and (26.5±4.1weeks) for ICEF group (P>0.05). Translation and angulation in lateral view for CHSF group were all less than that for ICEF group (P<0.001). At the final follow-up, no significant differences were found between the two groups concerning the ASAMI scores and complication rate (P>0.05).
Conclusion: In terms of final clinical outcomes, there is no statistically significant difference between CHSF and ICEF in treating HETSFs. Nevertheless, CHSF is superior to ICEF in aspects of operation time and tibial fracture reduction.
Organic Molecules are Deterministically Assembled across River Corridor Sediments
Authors: Stegen James , Garayburu-Caruso Vanessa , Danczak Robert , Chu Rosalie , Goldman Amy , McKever Sophia , Renteria Lupita , Toyoda Jason , Consortium WHONDRS 
Published: September 2023

Abstract
Dissolved organic matter (DOM) is central to ecosystem function. A fundamental challenge is understanding the processes leading to variation in the chemistry of organic molecules that comprise DOM. Here we study these processes in variably inundated riverbed sediments, as an understudied, yet ubiquitous component of rivers. Using null-model approaches adopted from community ecology, we found that within-site variation in environmental conditions caused non-random (i.e., deterministic) shifts in DOM chemistry. Deterministic shifts were observed across diverse biomes, though the strength of determinism varied substantially. We found that the strength of determinism decreased with increasing sediment moisture, but in the form of a constraint space. Many systems fell below the upper constraint boundary, however. We propose a conceptual model based on our results and other publications in which DOM assemblages are hypothesized to be increasingly deterministic across the continuum from the river water column to saturated sediment pore spaces to unsaturated and dry soils/sediments.
Impaired reinforcement learning and behavioral activation/inhibition systems in internet addiction
Authors: Chen Jin , Xie Ze-Yuan , Chen Tian-Zhen , Lu Jian-Xia , Zeng Ning-Ning , Zheng Hui 
Published: September 2023

Abstract
Background
The goal of this study is to examine whether goal-directed control and learning rate are more closely associated with internet addiction (IA) and analyze maladaptive behavior in IA through reinforcement learning processes and personality traits by looking at the personality traits of people with IA, thereby validating its alternative for diagnosing and measuring IA.
Methods
A total of sixty-one participants with IA and sixty-one healthy participants completed the Internet Addiction Test (IAT), the Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scale, and the two-step Markov decision task. Through hybrid modeling and multivariate regression, the relationship between reinforcement learning parameters, personality traits, and IA scores was analyzed.
Results
Significant impairment in goal-directed system was observed in the IA group, although this impairment did not correlate with the degree of IA. In comparison to the healthy control group, the IA group exhibited a significantly higher learning rate, which was positively correlated with the severity of IA and reward sensitivity. Furthermore, the BIS score and learning rate were predictive of IAT scores.
Conclusions
Maladaptive behavior in IA can be attributed partially to deficits in goal-directed system and an elevated learning rate. Individuals with a higher BIS sensitivity are more likely to experience IA. Incorporating behavioral modeling parameters and personality factors might aid in IA diagnosis.
Safety and effectiveness of atrial fibrillation ablation in patients aged ≥80 years: a retrospective study
Authors: Sakamoto Yusuke , Osanai Hiroyuki , Tanaka Yuki , Hiramatsu Shotaro , Arai Kenji , Watanabe Takashi , Ohguchi Shiou , Nakashima Yoshihito , Asano Hiroshi , Ajioka Masayoshi 
Published: September 2023

Abstract
Background
Catheter ablation is the first-line treatment for atrial fibrillation (AF). Although the efficacy and safety of this procedure have been reported in older patients, this might diminish with age. Therefore, this study aimed to determine the safety and effectiveness of AF ablation in patients aged ≥ 80 years.
Methods
We retrospectively analyzed the features of ablation and the subsequent clinical course and outcomes of 100 patients with AF aged ≥ 80 years who underwent ablation between July 2019 and December 2021 at Tosei General Hospital, Seto, Aichi, Japan.
Results
The average duration of AF was 6.0 ± 9.5 months, and 83% of the patients were symptomatic. Approximately 30% of the patients developed heart failure, with 15% requiring hospitalization within 1 year before ablation. Postablation, 93% of patients remained free of AF, and none required postoperative hospitalization due to heart failure. However, several complications were observed, including cardiac tamponade, hematoma at the access site, and postoperative bradycardia. Notably, an enlarged left atrial diameter before ablation was a predictor of complications.
Conclusions
In patients aged ≥ 80 years, AF ablation therapy demonstrated a high nonrecurrence rate and altered progression of heart failure. Although the incidence of complications was relatively low, caution should be exercised when older patients with enlarged left atrial diameters undergo AF ablation.