bluuebunny/crossref_metadata_2025_split huggingface dataset:
Government subsidy and firm's cost sharing in sustainable agriculture supply chain
Authors: He Yong , Yu Yanan , Guo Xiaotong , Li Dong 
Published: April 2023

SummaryThis paper studies an agriculture supply chain consisting of a government, a leading firm and a group of farmers. The government encourages farmers to make sustainable technologies' input by providing cost share or flat payment. The firm procures products from multiple farmers and shares a portion of input costs. The optimal sustainable technologies' input, wholesale price and government subsidy are determined, and the impacts of different parameters on the decisions with the endogenous or exogenous subsidy are analysed. The results show that when competition intensifies to a certain threshold, farmers will not invest in sustainable technologies. When the subsidy is endogenous, the firm will obtain less profit if he shares more costs because the optimal subsidy decreases with the cost‐sharing proportion. When the subsidy is exogenous, the farmers' optimal sustainable technologies' input under the government's cost share is higher, and the firm may obtain more profit with cost sharing if the subsidy is relatively high. The government provides a higher subsidy to motivate farmers to adopt sustainable technologies when the pollution is more environmentally damaging. The government's cost share is superior to flat payment because it alleviates the government's financial burden with the same effect on motivating sustainable technologies' input.
Careless hospitality: Family reunification in Ireland involving children and young people of international protection background
Authors: Smith Karen , Raghallaigh Muireann Ní , Johnson Derina 
Published: April 2023

AbstractThis article examines policy and provision in relation to family reunification for persons with international protection status in Ireland through the lens of hospitality. The particular focus is on reunification involving children and young people, including former unaccompanied minors. Drawing on interviews and focus groups with sponsors, reunited family members and service providers, the article identifies various policy gaps and deficiencies which create immense difficulties for children/young people and their families in the period after reunification. There is found to be a heavy burden of responsibility for sponsors, particularly young sponsors and a significant risk of housing precarity and homelessness for family members admitted to Ireland to join them. It is argued that while the right to reunification is protected under Irish law, the hospitality extended to those admitted under reunification mechanisms is in practice limited and characterised by carelessness in relation to experiences and outcomes.
Comparison of different approaches to multistage lot sizing with uncertain demand
Authors: Bindewald Viktor , Dunke Fabian , Nickel Stefan 
Published: April 2023

AbstractWe study a new variant of the classical lot sizing problem with uncertain demand where neither the planning horizon nor demands are known exactly. This situation arises in practice when customer demands arriving over time are confirmed rather lately during the transportation process. In terms of planning, this setting necessitates a rolling horizon procedure where the overall multistage problem is dissolved into a series of coupled snapshot problems under uncertainty. Depending on the available data and risk disposition, different approaches from online optimization, stochastic programming, and robust optimization are viable to model and solve the snapshot problems. We evaluate the impact of the selected methodology on the overall solution quality using a methodology‐agnostic framework for multistage decision‐making under uncertainty. We provide computational results on lot sizing within a rolling horizon regarding different types of uncertainty, solution approaches, and the value of available information about upcoming demands.
The association between nurse continuity and hypospadias repair patient outcomes: A retrospective study
Authors: Ji Yoonhye , Choi Eun Kyoung , Han Sang Won 
Published: April 2023

AbstractBackgroundRecently, nurse continuity, the intensity and consistency of a patient's exposure to nurses during hospitalization, has been shown to be associated with patient outcomes. However, little is known about how nurse continuity is related to patients' surgical outcomes.AimsTo examine the association between nurse continuity and outcomes of hypospadias repair to clarify the importance of nurse continuity as a nursing practice.DesignThis is a retrospective study.MethodsWe analysed the data from electronic health records of patients under 1 year who had undergone proximal hypospadias repair between January 2014 and December 2016. Nurse continuity was measured using the Continuity of Care Index. Since approximately half of the patients reportedly needed further operations in the long term, the primary outcome was whether patients with proximal hypospadias repair had two or more additional operations within 3 years of discharge.ResultsThe rate of undergoing two or more follow‐up operations in 3 years was significantly higher in patients with low nurse continuity—38.6% versus 12.8% for high continuity.ConclusionThis study identified nurse continuity as an important factor related to patients' surgical outcomes. These findings suggest that nurse continuity be considered an important nursing strategy for patient outcomes and further research is needed on this topic.Impact StatementAs empirical evidence regarding the association between nurse continuity and patient outcomes grows, nurse managers and policymakers should view nurse continuity as a critical factor for positive patient outcomes when considering nursing workforce regulations.No Patient or Public ContributionThe data for this study were obtained from electronic health records, and the entire process of this study did not involve patient or public participation.
Sunda–Sahul floristic exchange and pathways into the Southwest Pacific: New insights from wet tropical forest trees
Authors: Holzmeyer Laura , Hauenschild Frank , Muellner‐Riehl Alexandra N. 
Published: April 2023

AbstractAimRecent investigations on the floristic exchange between Southeast Asia and Australia have shown a clear dispersal directionality bias (West to East) of wet‐adapted plant taxa. However, dispersal routes and directions of wet forest taxa into the South Pacific remain insufficiently known. We here aimed to establish the most likely routes and directions of plant dispersal into the Southwest Pacific islands.LocationSoutheast Asia, East Asia, Australia, Southwest Pacific.TaxonDysoxylum s.l. (Meliaceae). This includes Dysoxylum s.s., Didymocheton, Epicharis, Goniocheton, Pseudocarapa, and Prasoxylon.MethodWe sampled 75% of the species diversity in Dysoxylum s.l., covering the entire distribution range, all genera and major lineages. Phylogenetic relationships of 149 accessions were reconstructed using Bayesian Evolutionary Analysis and two internal constraints. The dispersal–extinction–cladogenesis variant, founder‐event speciation (DEC+J), was used for reconstructing the biogeographic history, and 100 Biogeographical Stochastic Mappings were simulated.ResultsDysoxylum s.l. originated and firstly diversified in the western part of its current distribution range (including Indochina) during the Miocene to Pliocene, followed by an overall eastern range expansion towards Malesia, Australia and the Southwest Pacific in the Pliocene.Main ConclusionsThe south‐eastward expansion of lineages into Wallacea and Australia is in temporal agreement with the convergence of the Asian and Australian tectonic plates since the Miocene. Long‐distance dispersal is the main mechanism that led to the current distribution. Two dispersal pathways into the Southwest Pacific are identified, (1) through New Guinea and the Solomon Islands to Fiji, and (2) from New Zealand to Fiji. For both routes, Fiji was an important secondary source area for dispersal into the Southwest Pacific.
WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression
Authors: Yan Jia , Zhang Ming Yang , Lin Jing , Li Ke Xin , Zhao Zhi Min , Gao Yu Min , Deng Xiu Ling , Wang Chang Shan , Wang Hai Sheng 
Published: April 2023

AbstractWolf–Hirschhorn syndrome candidate 1 (WHSC1) is a transcriptional regulatory protein that encodes a histone methyltransferase to control H3K36me2 modification. WHSC1 was upregulated and associated with poor prognosis in HCC. The elevated WHSC1 likely due to the alterations of DNA methylation or RNA modification. WHSC1 perhaps form a chromatin cross talk with H3K27me3 and DNA methylation to regulate transcription factors expression in HCC. Functional analysis indicated that WHSC1 was involved in DNA damage repair, cell cycle, cellular senescence and immune regulations. Furthermore, WHSC1 was associated with the infiltrating levels of B cell, CD4+, Tregs and macrophage cells. Therefore, our findings suggested that WHSC1 might function as a promotor regulator to affect the development and progression of HCC. Thus, WHSC1 could be a potential biomarker in predicting the prognosis and therapeutic target for patients with HCC.
Correlated responses in basal immune function in response to selection for fast development in Drosophila melanogaster
Authors: Shrivastava Nidhi Krishna , Shakarad Mallikarjun N. 
Published: April 2023

AbstractOften, immunity is invoked in the context of infection, disease and injury. However, an ever alert and robust immune system is essential for maintaining good health, but resource investment into immunity needs to be traded off against allocation to other functions. In this study, we study the consequences of such a trade‐off with growth by ascertaining various components of baseline innate immunity in two types of Drosophila melanogaster populations selected for fast development, in combination with either a long effective lifespan (FLJs) or a short effective lifespan (FEJs). We found that distinct immunological parameters were constitutively elevated in both, FLJs and FEJs compared to their ancestral control (JB) populations, and these constitutive elevated immunological parameters were associated with reduced insulin signalling and comparable total gut microbiota. Our results bring into focus the inter‐relationship between egg to adult development time, ecdysone levels, larval gut microbiota, insulin signalling, adult reproductive longevity and immune function. We discuss how changes in selection pressures operating on life‐history traits can modulate different components of immune system.
Impact of educational attainment on time to cognitive decline among marginalized older adults: Cohort study of 20,311 adults
Authors: Jester Dylan J. , Palmer Barton W. , Thomas Michael L. , Brown Lauren L. , Tibiriçá Lize , Jeste Dilip V. , Gilmer Todd 
Published: April 2023

AbstractBackgroundThe effect of years of education on the maintenance of healthy cognitive functioning may differ by race and ethnicity given historical and ongoing inequities in educational quality.MethodsWe examined 20,311 Black, Latinx, and White adults aged 51–100 from the Health and Retirement Study (2008–2016). Telephone Interview for Cognitive Status‐27 data was used to measure cognitive functioning. Generalized additive mixed models were stratified by race and ethnicity and educational attainment (≥12 vs. <12 years). Selected social determinants of health, all‐cause mortality, time‐varying health and healthcare utilization characteristics, and study wave were included as covariates.ResultsOn average, Black and Latinx adults scored lower at baseline compared to White adults regardless of educational attainment (p < 0.001), with a significant overlap in the distributions of scores. The rate of cognitive decline was non‐linear for Black, Latinx, and White adults (p < 0.001), and a period of stability was witnessed for those with higher educational attainment irrespective of race and ethnicity. Compared to Black, Latinx, and White adults with lower educational attainment, higher‐educated White adults received the greatest protection from cognitive decline (13 years; 64 vs. 51), followed by Latinx (12 years; 67 vs. 55), and Black adults (10 years; 61 vs. 51). Latinx adults experienced cognitive decline beginning at a later age.ConclusionsThe extent to which higher educational attainment protects adults from cognitive decline differs by race and ethnicity, such that higher‐educated White adults received a greater benefit than higher‐educated Black or Latinx adults.
A high‐resolution transcriptomic atlas depicting nitrogen fixation and nodule development in soybean
Authors: Sun Baocheng , Wang Yu , Yang Qun , Gao Han , Niu Haiyu , Li Yansong , Ma Qun , Huan Qing , Qian Wenfeng , Ren Bo 
Published: April 2023

ABSTRACTAlthough root nodules are essential for biological nitrogen fixation in legumes, the cell types and molecular regulatory mechanisms contributing to nodule development and nitrogen fixation in determinate nodule legumes, such as soybean (Glycine max), remain incompletely understood. Here, we generated a single‐nucleus resolution transcriptomic atlas of soybean roots and nodules at 14 days post inoculation (dpi) and annotated 17 major cell types, including six that are specific to nodules. We identified the specific cell types responsible for each step in the ureides synthesis pathway, which enables spatial compartmentalization of biochemical reactions during soybean nitrogen fixation. By utilizing RNA velocity analysis, we reconstructed the differentiation dynamics of soybean nodules, which differs from those of indeterminate nodules in Medicago truncatula. Moreover, we identified several putative regulators of soybean nodulation and two of these genes, GmbHLH93 and GmSCL1, were as‐yet uncharacterized in soybean. Overexpression of each gene in soybean hairy root systems validated their respective roles in nodulation. Notably, enrichment for cytokinin‐related genes in soybean nodules led to identification of the cytokinin receptor, GmCRE1, as a prominent component of the nodulation pathway. GmCRE1 knockout in soybean resulted in a striking nodule phenotype with decreased nitrogen fixation zone and depletion of leghemoglobins, accompanied by downregulation of nodule‐specific gene expression, as well as almost complete abrogation of biological nitrogen fixation. In summary, this study provides a comprehensive perspective of the cellular landscape during soybean nodulation, shedding light on the underlying metabolic and developmental mechanisms of soybean nodule formation.
Facial rejuvenation with the new hybrid filler HArmonyCa™: Clinical and aesthetic outcomes assessed by 2D and 3D photographs, ultrasound, and elastography
Authors: Urdiales‐Gálvez Fernando , Braz André , Cavallini Maurizio 
Published: April 2023

AbstractObjectiveFacial aging is a complex process that involves genetic, biological, and environmental factors. This paper aimed to present the first aesthetic and safety outcomes of a hybrid filler that combines hyaluronic acid (HA) (20 mg/mL) and calcium hydroxyapatite (HA/CaHa).MethodsProspective and non‐randomized interventional study conducted on consecutive healthy patients who attended the clinic for an aesthetic facial rejuvenation procedure. HA/CaHa was injected with 23G cannula (retrograde threads, 1.25 mL per side) in the preauricular region. Ultrasound examinations, elastography images, and 2D and 3D photographs were performed before and after treatment. The primary endpoint were the volumetric changes at Day 180.ResultsFifteen patients were included in the study. At Day 180 after treatment, median (interquartile‐range) volume increased by 2.1 (1.9–2.3) cc and 2.1 (1.8–2.2) cc in the right‐ and left‐side, respectively, p < 0.0001 each. As compared to pretreatment values, facial‐tension vectors significantly increased by 2.2 (1.6–2.2) mm and 2.0 (1.7–2.2) mm in the right and left side, respectively, p < 0.0001 each. Elastography images demonstrated an increase in collagen fibers at post‐treatment Day 60, which was confirmed on Day 90, and reached the peak effect between Days 90 and 180. Regarding safety, there were no either unexpected or serious treatment‐related adverse events. Most patients experienced a mild redness and inflammation that resolved within the first 48 h without treatment.ConclusionsThe HA/CaHa hybrid filler (HArmonyCa™), besides its volumizing and lifting properties, was associated with an increase in the viscoelasticity, both at the level of the reticular dermis and the subcutaneous cellular tissue, which might be indicative of the formation of new collagen fibers.
The association between sleep bruxism and awake bruxism: Polysomnographic and electromyographic recordings in women with and without myofascial pain
Authors: Chattrattrai Thiprawee , Janal Malvin N. , Lobbezoo Frank , Raphael Karen G. 
Published: April 2023

AbstractBackgroundSleep bruxism (SB) and awake bruxism (AB) are masticatory muscle activities that are rarely assessed in the same individuals and are thought to be associated with different behaviours.ObjectivesTo investigate whether individuals engaging in SB also engage in AB, that occurs during rest and during stress‐related activity, and to investigate whether SB and AB are associated with different characteristics.MethodsFemales with myofascial pain (N = 122) and non‐myofascial pain controls (N = 46) were evaluated for SB events and for AB events at rest and AB during stress‐related activity, using electromyographic (EMG) recordings and a standardised scoring of bruxism events. The joint distributions between SB and AB events and EMG activity were evaluated, and the characteristic qualities of SB and AB were assessed.ResultsNeither SB event rates nor the EMG activity associated with those events was associated with AB events rates or EMG activity, either at rest or during stress‐related activity. On the contrary, event rates and EMG activity when awake and at rest were positively associated with events and activity during stress‐related activity. SB was characterised mainly by grinding, while AB was characterised mainly by clenching.ConclusionSleep bruxism and awake bruxism do not tend to occur in the same individuals.
Job characteristics and personality change in young adulthood: A 12‐year longitudinal study and replication
Authors: Zheng Anqing , Hoff Kevin A. , Hanna Alexis , Einarsdóttir Sif , Rounds James , Briley D. A. 
Published: April 2023

AbstractObjectivePersonality changes are related to successfully performing adult occupational roles which require teamwork, duty, and managing stress. However, it is unclear how personality development relates to specific job characteristics that vary across occupations.MethodWe investigated whether 151 objective job characteristics, derived from the Occupational Information Network (O*NET), were associated with personality levels and changes in a 12‐year longitudinal sample followed over the school to work transition. Using cross‐validated regularized modeling, we combined two Icelandic longitudinal datasets (total N = 1054) and constructed an individual‐level, aggregated job characteristics score that maximized prediction of personality levels at baseline and change over time.ResultsThe strongest association was found for level of openness (0.25), followed by conscientiousness (0.16) and extraversion (0.14). Overall, aggregated job characteristics had a stronger prediction for personality intercepts (0.14) than slopes (0.10). These results were subsequently replicated in a U.S. sample using levels of the Big Five as the dependent variable. This indicates that associations between job characteristics and personality are generalizable across life stages and nations.ConclusionsOur findings suggest that job titles are a valuable resource that can be linked to personality to better understand factors that influence psychological development. Further work is needed to document the prospective validity of job characteristics across a wider range of occupations and age.
Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome
Authors: Lynch Alex M. , Ruterbories Laura K. , Robertson James B. , Lunn Katharine F. , Mowat Freya M. 
Published: April 2023

AbstractBackgroundSudden acquired retinal degeneration syndrome (SARDS) is a common cause of irreversible blindness in dogs. It bears clinical resemblance to hypercortisolism, which can be associated with hypercoagulability. The role of hypercoagulability in dogs with SARDS is unknown.ObjectiveDetermine hemostatic profiles in dogs with SARDS.AnimalsProspective pilot study: Dogs with a history of SARDS (n = 12). Prospective case‐control study: Dogs with recent onset of SARDS (n = 7) and age‐, breed‐, and sex‐matched controls (n = 7).MethodsProspective pilot study: We performed thromboelastography (TEG). Prospective case‐control study: Dogs had CBC, serum biochemistry, urinalysis, TEG, fibrinogen concentration, antithrombin activity, D‐dimers, thrombin‐antithrombin complexes, and optical platelet aggregometry performed.ResultsProspective pilot study: 9/12 dogs with a history of SARDS were hypercoagulable with increased TEG G value and 2/3 had hyperfibrinogenemia. Case‐control study: All dogs with SARDS and 5/7 controls were hypercoagulable based on TEG G value. Dogs with SARDS had significantly higher G values (median, 12.7 kdynes/s; range, 11.2‐25.4; P = .04) and plasma fibrinogen concentration (median, 463 mg/dL; range, 391‐680; P < .001) compared to controls.Conclusions and Clinical ImportanceHypercoagulability was common in both dogs with SARDS and controls, but dogs with SARDS were significantly more hypercoagulable on TEG. The role of hypercoagulability in the pathogenesis of SARDS remains to be determined.
The effect of vaccine‐associated cross‐stitch vertebrae pathology on growth of farmed Atlantic salmon
Authors: Thorarinsson Ragnar , Negaard Paul , Baeverfjord Grete , Peña Patricio , Skjerve Eystein 
Published: April 2023

AbstractA field study comparing two vaccine regimes against pancreas disease (PD) was carried out in 2018 S0 year class smolts at two commercial sea cage sites in southern Norway. The fish from the same hatchery source were immunized using licensed vaccines; either a DNA PD vaccine and a hexavalent oil‐adjuvanted vaccine (group A), or a heptavalent oil‐adjuvanted PD vaccine (group B). The experimental design included the two fish groups reared together (15% as group A and 85% as group B) in four large hatchery tanks. These fish groups were later transferred to four production cages at two separate sea sites (two cages per site). In the absence of any notable PD prior to the pre‐harvest sampling, the primary objective and outcome variables entailed evaluation of vaccine side effects and their impact on growth. The results show that vaccine and sea cage site significantly impacted prevalence and severity of a newly described pathology named cross‐stitch vertebrae. Further, moderate to severe cross‐stitch pathology (scores ≥3) resulted in significantly reduced growth.