bluuebunny/crossref_metadata_2025_split huggingface dataset:
NGHIÊN CỨU TÌNH HÌNH TRẦM CẢM Ở PHỤ NỮ THAI NGHÉN NGUY CƠ CAO ĐANG ĐIỀU TRỊ TẠI BỆNH VIỆN PHỤ SẢN - NHI ĐÀ NẴNG
Authors: Dương Thị Kim Hoa , Phạm Thị Minh Quyên , Ngô Thị Hồng Lĩnh 
Published: April 2023

Đặt vấn đề: Trầm cảm ở phụ nữ mang thai nếu không được phát hiện và điều trị kịp thời thì sẽ gây những tác hại đáng kể cho cả mẹ và con, đặc biệt ở những phụ nữ thai nghén nguy cơ cao: làm tăng nguy cơ sinh non, sinh trẻ nhẹ cân, ảnh hưởng đến sự phát triển tinh thần, tính cách của trẻ trong tương lai; hoặc tăng nguy cơ trầm cảm sau sinh, mắc bệnh tâm thần đối với mẹ. Mục tiêu nghiên cứu: Xác định tỷ lệ trầm cảm theo thang đo Edinburgh (EPDS) và tìm hiểu một số yếu tố liên quan đến trầm cảm ở phụ nữ thai nghén nguy cơ cao đang điều trị tại Bệnh viện Phụ sản – Nhi Đà Nẵng. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, tiến hành trên 312 phụ nữ thai nghén nguy cơ cao đang điều trị tại Bệnh viện Phụ sản – Nhi Đà Nẵng từ tháng 2 đến tháng 9 năm 2022. Kết quả: Tỷ lệ trầm cảm ở phụ nữ thai nghén nguy cơ cao là 36,5% và một số yếu tố liên quan: sống một mình; tiền sử có mắc Covid – 19, bệnh lý về máu; có hút thuốc lá, thai kỳ lần này không mong đợi, có rối loạn giấc ngủ và có lo lắng buồn phiền khác kèm theo (p<0,05). Kết luận: Tỷ lệ trầm cảm ở phụ nữ thai nghén nguy cơ cao có xu hướng tăng, bên cạnh các yếu tố liên quan đến tiền sử bệnh tật thì một số yếu tố tâm lý, xã hội cũng đóng vai trò quan trọng để làm tăng tỷ lệ trầm cảm.
THỰC TRẠNG RÁC THẢI TẠI MỘT SỐ TRƯỜNG TRUNG HỌC CƠ SỞ Ở QUẬN THANH KHÊ, THÀNH PHỐ ĐÀ NẴNG NĂM 2022
Authors: Hoàng Nguyễn Nhật Linh , Nguyễn Thị Thúy Nga , Nguyễn Trần Anh Vũ , Trần Đăng Trung , Trần Minh Huân 
Published: April 2023

Đặt vấn đề: Rác thải, đặc biệt là rác nhựa là một trong những nguyên nhân gây nên tình trạng ô nhiễm môi trường nghiêm trọng. Trong đó, rác thải từ trường học đang đóng góp một phần lớn vào lượng rác chung thải ra môi trường mỗi ngày. Mục tiêu nghiên cứu: Mô tả thực trạng rác thải tại 2 trường THCS tại quận Thanh Khê, Đà Nẵng. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang, thu thập dữ liệu rác thải trong 5 ngày và kiểm toán rác thải theo phương pháp của Tổ chức Quốc tế về Bảo tồn Thiên nhiên Việt Nam (WWF-Việt Nam). Kết quả: Trung bình 01 ngày, 2 trường thải ra 23,4 kg rác; chiếm thể tích 967,3 lít; với số lượng 1910 cái (riêng rác hữu cơ và giấy không đếm). Lượng rác thải nhựa giá trị thấp chiếm tỷ lệ cao nhất về cả khối lượng, thể tích và số lượng (lần lượt 49%; 63% và 81%). Kết luận: Kết quả trên cảnh báo nguy cơ ô nhiễm nhựa nghiêm trọng có phần đóng góp lớn từ rác thải trường học. Từ kết quả này, nhóm nghiên cứu đề xuất các hoạt động truyền thông cho giáo viên – nhân viên và học sinh nhằm nâng cao kiến thức, thái độ và thay đổi hành vi tiến tới không rác nói chung và không rác nhựa nói riêng trong trường học và gia đình.
Editorial: From the Incoming Editors of the European Journal of Therapeutics (Eur J Ther)
Authors: Balat Ayşe , Eren Şevki Hakan , Menzilcioğlu Mehmet Sait , Bahşi İlhan 
Published: April 2023

Dear Colleagues,
We are delighted to share the new issue (June 2023, volume 29, Issue 2) of the European Journal of Therapeutics (Eur J Ther). Furthermore, we are honored to be appointed as the New Editor-in-Chief and New Deputies Editor-in-Chief of Eur J Ther, the international publication of the Gaziantep University Faculty of Medicine published since 1990.
First, we would like to thank the previous Editor-in-Chief, Prof. M. Murat Sucu, and his team for their hard work during their tenure. They significantly increased its contribution to the field and international reputation by further developing the journal.
In addition, we would like to express our gratitude to all the editors, authors, referees, and technical team who have contributed to the journal since 1990, when our journal first started being published.
Unfortunately, due to the change of publishing house, there were some technical problems and interruptions on the web page of Eur J Ther in the first few months of 2023. So, we regret to inform you that there are delays in the evaluation stages of some manuscripts sent to the journal. However, we would like to let you know that from now on, your valuable works submitted to Eur J Ther will be evaluated as quickly as possible. In addition, we would like to announce that all articles accepted for publication in our journal, which is considered an essential innovation, will be published on the web page of our journal as Early View / Accepted Articles in a short time. This innovation will expedite the citation process for your publications.
As the New Editor-in-Chief and New Deputies Editor-in-Chief, we aim to increase the quality and visibility of Eur J Ther and to improve its indexes.
We want to remind you that the journal’s target audience is researchers, physicians, and health professionals interested in or working in all medical and dental disciplines. Therefore, we request you submit your valuable research to Eur J Ther to contribute to the development and content of the journal.
Sincerely yours,

Editor-in-Chief
Ayşe Balat, MD

Deputies Editor-in-Chief
Şevki Hakan Eren, MD
Mehmet Sait Menzilcioğlu, MD
İlhan Bahşi, MD, PhD
Redaktionelt forord
Authors: Marcussen Martin 
Published: April 2023

Tilbage i september 2022 blev samtlige partier i Folketinget enige om et kommissorium for, hvad det hold af forskere, der skal opdatere den tidligere magtudredning fra 2003, skal fokusere på; og hvordan udredningen skal organiseres.
I dette temanummer af Økonomi & Politik, der er redigeret af Christoph Houman Ellersgaard og Anton Grau Larsen, har vi ønsket at give vores input til, hvad den kommende magtudredning eksempelvis kunne rette forskningsmæssig opmærksomhed mod. Dermed ligger temanummeret i forlængelse af et temanummer, der kredsede om samme emne fra 2018 (vol. 91, no. 1, Temaredaktørens forord (djoef-forlag.dk)). Listen er naturligvis langt fra udtømmende, men der argumenteres overbevisende for, at vi bl.a. mangler viden om magt i erhvervslivet og erhvervslivets magt, magt i medierne og mediernes magt, magt på arbejdsmarkedet, nye former for interessevaretagelse og rettens privatisering. Hertil kommer studiet af et væld af underliggende magtstrukturer, der kan knyttes til ulighed, eksklusion forskellige former for skævheder. Det hele kan studeres tværdisciplinært, i et internationalt perspektiv og med anvendelse af en bred vifte af data og metoder. Vores håb er, at forskningsledelsen og ikke mindst den allestedsnærværende følgegruppe vil gribe opgaven an med et åbent sind og med et inderligt ønske om at komme et spadestik dybere – også på de områder som interessenterne måske ikke i første omgang havde forestillet sig centrale i en udredning af magt.
Homoeopathic management of gastritis: a review.
Authors: Susanna Alajangi , Suresh Manhas Sushma 
Published: April 2023

Helicobacter pylori and bile reflux are the main causes of diffuse, acute or chronic stomach inflammation known as gastritis. The most frequent disorder seen in clinical practice is this one. Changes in dietary practices, such as irregular meal times, fast food, and addictions to alcohol and tobacco use, can play a significant influence. Despite not being as fatal as other serious illnesses, the symptoms can be upsetting, make it difficult to enjoy daily life, and put a strain on both the mind and body. If gastritis is not treated quickly, serious problems such peptic ulcers and pyloric stenosis might result, followed by perforation. A significant part of homoeopathy in the management of gastritis is extremely effective in treating both chronic and acute gastritis symptoms. Furthermore, it is crucial in preventing a relapse of the illness. Homoeopathic drugs, on the other hand, are helpful in the prevention and treatment of many aliments. This study therefore lists typical homoeopathic medications that can be used to treat or ward off gastritis.
Understanding The Concept of Susceptibility and its Assessment on Respiratory Tract Infection (RTIs) : A review
Authors: Dr. Vinodini Vasantrao Patil  , Moirangthem Krishnakumari 
Published: April 2023

Background:
Homoeopathy as a system of medicines & that deals with any disease condition in a holistic way brings to the needs of present scenario which possesses a better scope to reduce the recurrency of disease. Susceptibility is revealed by the reaction that occur when the host interacts with environmental factors by the sign and symptoms. Respiratory tract infections is spreading rapidly within the communities & represent the third most frequent health problem across the globe due to microorganism. The disease is vulnerable to infection than the other parts of body. The intensity of symptoms can be ranged from mild to severe. Most of the incidence is underestimated because of infection are mild & not hampers the daily activities until severity. According to WHO data published in 2017 death in India due to RTI (i.e. lung disease) reaches 8, 96, 77 or 10.19% which India ranks 4th in the world & adolescent & adults have approximately 2-4 cold in a year. By assessing the susceptibility and proper selection of potency of simillimum can bring an ideal cure. The study was to understand the concept of susceptibility and its application in RTI disease.
Aim and Objective: The aim of the study is to review on the available literature with objective to subject each research paper in order to shed light on the current topic and to find the way for new research.
Methods: Databases such as PubMed, Google Scholar, Medline and Science Direct were used to search the articles.
CONCLUSION: This study suggested that the importance of assessment of Susceptibility in Homoeopathy which helps in evaluation of cases and selection of potency and the curative dose of simillimum. As Homoeopathic medicine gives effectively relief to the patient and restoration of the normal susceptibility is the basis of cure.
KEYWORDS: Homoeopathy, RTI, Susceptibility, Simillimum
Acute Toxicity and Anxiolytic Activity Screening of Hydroalcoholic Leaf Extracts of Bryophyllum pinnatum, Terminalia catappa and Tapinanthus dodoneifolius Growing on Terminalia catappa Tree in MIce
Authors: Umarudeen A. M. , Magaji M. G. , Khan F. , Abubakar A. 
Published: April 2023

Aims: Hydroalcoholic T. dodoneifolius, B.pinnatum and T. catappa leaf extracts were investigated for their acute toxicity and anxiolytic activities.
Study Design: Acute toxicity (LD50) was determined using the limit dose acute and Anxiolytic activities were assessed by open-field field behavioural testing in mice.
Place and Duration of Study: The study took place in the Neurobehavioural room of Department of Pharmacology & Therapeutics, Faculty of Pharmacy, Ahmadu Bello University, Zaria in late December 2022.
Methodology: Groups of mice (n=6; equal sexes) were each exposed to the open-field paradigm (OFT) following 1 hour of single oral administration of distilled water, extracts (125, 250, and 500 mg/kg) and diazepam (0. 5 mg/kg) using the behavioural indices of mean centre zone time (M%CZT), centre zone re-entry (MCZR) and defeaction/urination frequency (MD/UF).
Results: Acute toxicity testing shows that the three extracts are safe with LD50 of 5g/kg. Behavioural results indicate, compared to the distilled water treatment (M%CZT, 6.39±1.53; MCZR, 4.67±1.15, & MU/UF, 4.83±0.75), single acute T. dodoneifolius (M%CZT, 7.50±1.73, 13.72±2.43, & 20.94±3.91*; MCZR, 7.33±0.88, 9.50±0.76, & 11.50±1.6*; MD/UF, 4.17±0.48, 3.17±0.54, & 1.83±0.60*), and B.pinnatum (M%CZT, 9.72±1.91, 9.78±1.32, & 19.67±2.01*; MCZR, 6.00±1.15, 10.50±0.76, & 12.50±1.72*; MD/UF, 3.17±0.79, 2.33±0.42, & 1.33±0.49*) extract treatments demonstrated consistent dose-dependency in their anxiolytic activity across the three parameters with T. catappa extract (M%CZT, 6.95±1.27, 12.17±2.01, & 16.84±1.49*; MCZR, 8.17±1.60, 10.17±1.67, & 10.83±1.96; MD/UF, 2.83±0.60, 2.00±0.73, & 3.67±0.42) exhibiting dose-pendent anxiolytic effect only on the M%CZT. However, at the highest dose level of 500 mg/kg, all plant extract treatments caused anxiolytic effects that are comparable with those of 0.5 mg/kg diazepam treatments (M%CZT, 22.61±1.31*; MCZR, 12.17±1.66*; & MD/UF, 2.62±0.21*).
Conclusion: These findings justify the traditional use of these medicinal plant extracts in the remediation of nervous and related disorders.
Methodology for computed tomography characterization of commercially available 3D printing materials for use in radiology/radiation oncology
Authors: Kozee Madison , Weygand Joseph , Andreozzi Jacqueline M. , Hunt Dylan , Perez Bradford A. , Graham Jasmine A. , Redler Gage 
Published: April 2023

Abstract3D printing in medical physics provides opportunities for creating patient‐specific treatment devices and in‐house fabrication of imaging/dosimetry phantoms. This study characterizes several commercial fused deposition 3D printing materials with some containing nonstandard compositions. It is important to explore their similarities to human tissues and other materials encountered in patients. Uniform cylinders with infill from 50 to 100% at six evenly distributed intervals were printed using 13 different filaments. A novel approach rotating infill angle 10o between each layer avoids unwanted patterns. Five materials contained high‐Z/metallic components. A clinical CT scanner with a range of tube potentials (70, 80, 100, 120, 140 kVp) was used. Density and average Hounsfield unit (HU) were measured. A commercial GAMMEX phantom mimicking various human tissues provides a comparison. Utility of the lookup tables produced is demonstrated. A methodology for calibrating print materials/parameters for a desired HU is presented. Density and HU were determined for all materials as a function of tube voltage (kVp) and infill percentage. The range of HU (−732.0–10047.4 HU) and physical densities (0.36–3.52 g/cm3) encompassed most tissues/materials encountered in radiology/radiotherapy applications with many overlapping those of human tissues. Printing filaments doped with high‐Z materials demonstrated increased attenuation due to the photoelectric effect with decreased kVp, as found in certain endogenous materials (e.g., bone). HU was faithfully reproduced (within one standard deviation) in a 3D‐printed mimic of a commercial anthropomorphic phantom section. Characterization of commercially available 3D print materials facilitates custom object fabrication for use in radiology and radiation oncology, including human tissue and common exogenous implant mimics. This allows for cost reduction and increased flexibility to fabricate novel phantoms or patient‐specific devices imaging and dosimetry purposes. A formalism for calibrating to specific CT scanner, printer, and filament type/batch is presented. Utility is demonstrated by printing a commercial anthropomorphic phantom copy.
ECM‐Like Adhesive Hydrogel for the Regeneration of Large Corneal Stromal Defects
Authors: Wang Fuyan , Zhang Wei , Qiao Yujie , Shi Depeng , Hu Lizhi , Cheng Jun , Wu Jingyi , Zhao Long , Li Donfang , Shi Weiyun , Xie Lixin , Zhou Qingjun 
Published: April 2023

AbstractThe repair of large‐diameter corneal stroma defects is a major clinical problem. Although some studies have attempted to use hydrogels to repair corneal damage, most of these hydrogels can only be used for focal stromal defects that are ≤3.5 mm in diameter due to poor hydrogel adhesion. Here, a photocurable adhesive hydrogel that mimics the extracellular matrix (ECM) with regard to composition for repairing 6 mm‐diameter corneal stromal defects in rabbits is investigated. This ECM‐like adhesive can be rapidly cured after light exposure, with high light transmittance and good mechanical properties. More importantly, this hydrogel maintains the viability and adhesion of cornea‐derived cells and promotes their migration in vitro in 2D and 3D culture environments. Proteomics analysis confirms that the hydrogel promotes cell proliferation and ECM synthesis. Furthermore, in rabbit corneal stromal defect repair experiments, it is proven by histological and proteomic analysis that this hydrogel can effectively promote corneal stroma repair, reduce scar formation, and increase corneal stromal–neural regeneration at the six months follow‐up. This work demonstrates the great application of ECM‐like adhesive hydrogels for the regeneration of large‐diameter corneal defects.
Recent Advances of Platinum‐Based Anticancer Complexes in Combinational Multimodal Therapy
Authors: Zhong Tianyuan , Yu Jie , Pan Yong , Zhang Ning , Qi Yanxin , Huang Yubin 
Published: April 2023

AbstractPlatinum drugs with manifest therapeutic effects are widely used, but their systemic toxicity and the drug resistance acquired by cancer cells limit their clinical applications. Thus, the exploration on appropriate methods and strategies to overcome the limitations of traditional platinum drugs becomes extremely necessary. Combination therapy of platinum drugs can inhibit tumor growth and metastasis in an additive or synergistic manner, and can potentially reduce the systemic toxicity of platinum drugs and overcome platinum‐resistance. This review summarizes the various modalities and current progress in platinum‐based combination therapy. The synthetic strategies and therapeutic effects of some platinum‐based anticancer complexes in the combination of platinum drugs with gene editing, ROS‐based therapy, thermal therapy, immunotherapy, biological modelling, photoactivation, supramolecular self‐assembly and imaging modality are briefly described. Their potential challenges and prospects are also discussed. It is hoped that this review will inspire researchers to have more ideas for the future development of highly effective platinum‐based anti‐cancer complexes.
Immunostimulatory DNA Hydrogel Enhances Protective Efficacy of Nanotoxoids against Bacterial Infection
Authors: Guo Zhongyuan , Zhou Jiarong , Yu Yiyan , Krishnan Nishta , Noh Ilkoo , Zhu Audrey Ting , Borum Raina M. , Gao Weiwei , Fang Ronnie H. , Zhang Liangfang 
Published: April 2023

AbstractWhile vaccines have been highly successful in protecting against various infections, there are still many high‐priority pathogens for which there are no clinically approved formulations. To overcome this challenge, researchers have explored the use of nanoparticulate strategies for more effective antigen delivery to the immune system. Along these lines, nanotoxoids are a promising biomimetic platform that leverages cell membrane coating technology to safely deliver otherwise toxic bacterial antigens in their native form for antivirulence vaccination. Here, in order to further boost their immunogenicity, nanotoxoids formulated against staphylococcal α‐hemolysin are embedded into a DNA‐based hydrogel with immunostimulatory CpG motifs. The resulting nanoparticle–hydrogel composite is injectable and improves the in vivo delivery of vaccine antigens while simultaneously stimulating nearby immune cells. This leads to elevated antibody production and stronger antigen‐specific cellular immune responses. In murine models of pneumonia and skin infection caused by methicillin‐resistant Staphylococcus aureus, mice vaccinated with the hybrid vaccine formulation are well‐protected. This work highlights the benefits of combining nanoparticulate antigen delivery systems with immunostimulatory hydrogels into a single platform, and the approach can be readily generalized to a wide range of infectious diseases.
Covalently Functionalized Leakage‐Free Healable Phase‐Change Interface Materials with Extraordinary High‐Thermal Conductivity and Low‐Thermal Resistance
Authors: Abdul Jaleel Shabas Ahammed , Kim Taehun , Baik Seunghyun 
Published: April 2023

AbstractPhase‐change materials (PCMs) have received considerable attention to take advantage of both pad‐type and grease‐type thermal interface materials (TIMs). However, the critical drawbacks of leaking, non‐recyclability, and low thermal conductivity (κ) hinder industrial applications of PCM TIMs. Here, leakage‐free healable PCM TIMs with extraordinarily highκand low total thermal resistance (Rt) are reported. The matrix material (OP) is synthesized by covalently functionalizing octadecanol PCM with polyethylene‐co‐methyl acrylate‐co‐glycidyl methacrylate polymer through the nucleophilic epoxy ring opening reaction. The OP changes from semicrystalline to amorphous above the phase‐transition temperature, preventing leaking. The hydrogen‐bond‐forming functional groups in OP enable nearly perfect healing efficiencies in tensile strength (99.7%),κ(97.0%), andRt(97.4%). Elaborately designed thermally conductive fillers, silver flakes and multiwalled carbon nanotubes decorated with silver nanoparticles (nAgMWNTs), are additionally introduced in the OP matrix (OP‐Ag‐nAgMWNT). The nAgMWNTs bridge silver‐flake islands, resulting in extraordinarily highκ(43.4 W m−1 K−1) and lowRt(30.5 mm2 K W−1) compared with PCM TIMs in the literature. Excellent heat dissipation and recycling demonstration of the OP‐Ag‐nAgMWNT is also carried out using a computer graphic processing unit. The OP‐Ag‐nAgMWNT is a promising future TIM for thermal management of mechanical and electrical devices.
Dynamic Motions of Topological Defects in Nematic Liquid Crystals under Spatial Confinement
Authors: Pawale Tejal , Swain Justin , Hashemi Mohammad Reza , Tierra Giordano , Li Xiao 
Published: April 2023

AbstractTopological defects (TDs) have become a sensational topic due to their significant influence on the unusual optical and physiochemical characteristics of the material. To facilitate their application across a wide range of disciplines it is desirable to analyze and gain fundamental understanding of TDs in both equilibrium and nonequilibrium systems. Liquid crystals (LCs) are considered an ideal system for study given the direct visualization of TDs and a straightforward analyzation process. In addition to the equilibrium morphology of LC TDs, it is also of great interest to track and control the formation and annihilation of defects during thermodynamic processes. However, controlling the dynamic behavior of formed defects remains a challenge. Here, nematic LCs confined in a cell exhibiting surfaces with periodic anchoring conditions containing surface topography are relied on. The effects of patterned surface characteristics such as width, periodicity, and degree of curvature on defects dynamic motion, stabilization, and annihilation are explored. The computational experiments recapitulate the TDs transition path and provide free energy‐based predictions of critical distances for defect annihilation. Taken together, this simple approach offers a promising opportunity to control the dynamics of TDs in LCs through chemical patterned surfaces with topography.