bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synchronous Switching of Dielectric Constant and Photoluminescence in Cyanidonitridorhenate‐Based Crystals
Authors: Liberka Michal , Zychowicz Mikolaj , Hooper James , Nakabayashi Koji , Ohkoshi Shin‐ichi , Chorazy Szymon 
Published: August 2023

AbstractSwitching of multiple physical properties by external stimuli in dynamic materials enables applications in, e.g., smart sensors, biomedical tools, as well as data‐storage devices. Among stimuli‐responsive materials, inorganic‐organic molecular hybrids exhibiting thermal order‐disorder phase transitions were tested as promising molecular switches of electrical characteristics, including dielectric constant. We aimed at broadening the multifunctional potential of such hybrid materials towards the switching of not only electrical but also other physical properties, e.g., light emission. We report two ionic salts based on luminescent tetracyanidonitridorhenate(V) anions bearing two different diamine ligands, 1,2‐diaminoethane (1) and 1,3‐diaminopropane (2), both crystallizing with polar N‐methyl‐dabconium cations. They exhibit an order‐disorder phase transition related to the heating‐induced turning‐on of the rotation of polar cations. This leads to a unique synchronous switching of the dielectric constant as well as metal‐complex‐centered photoluminescence, as demonstrated by changes in, e.g., emission lifetime. The roles of organic cations, non‐trivial Re(V) complexes, and their interaction in achieving the coupled thermal switching of electrical and optical properties are discussed utilizing experimental and theoretical approaches.
Overcoming Cancer Resistance to Platinum Drugs by Inhibiting Cholesterol Metabolism
Authors: Wang Ying , Cai Linxiang , Li Hui , Chen Hanhua , Yang Tao , Tan Yehong , Guo Zijian , Wang Xiaoyong 
Published: August 2023

AbstractDrug resistance is a serious challenge for platinum anticancer drugs. Platinum complexes may get over the drug resistance via a distinct mechanism of action. Cholesterol is a key factor contributing to the drug resistance. Inhibiting cellular cholesterol synthesis and uptake provides an alternative strategy for cancer treatment. Platinum(IV) complexes FP and DFP with fenofibric acid as axial ligand(s) were designed to combat the drug resistance through regulating cholesterol metabolism besides damaging DNA. In addition to producing reactive oxygen species and active platinum(II) species to damage DNA, FP and DFP inhibited cellular cholesterol accumulation, promoted cholesterol efflux, upregulated peroxisome proliferator‐activated receptor alpha (PPARα), induced caspase‐1 activation and gasdermin D (GSDMD) cleavage, thus leading to both apoptosis and pyroptosis in cancer cells. The reduction of cholesterol significantly relieved the drug resistance of cancer cells. The double‐acting mechanism gave the complexes strong anticancer activity in vitro and in vivo, particularly against cisplatin‐resistant cancer cells.
Design and Synthesis of Artificial Nucleobases for Sequence‐Selective DNA Recognition within the Major Groove
Authors: Alavijeh Nahid S. , Serrano Alvaro , Peters Max S. , Wölper Christoph , Schrader Thomas 
Published: August 2023

AbstractWe present the design and synthesis of artificial specific nucleobases, each one recognizing a single base pair within the major groove of duplex DNA. Computational calculations indicate that PNAs modified with these nucleobases enable the formation of highly stable triple helices with no sequence restrictions through multiple hydrogen bonding and π⋅⋅⋅π stacking interactions, without significantly widening the DNA double helix. New synthetic routes were developed to the structures of these fused heterocycles which have rarely been described in the literature. NMR titration experiments indicate specific hydrogen bonding at the Hoogsteen sites. The new building blocks allow the construction of four PNA monomers for each canonic base pair and their covalent connection to PNA oligomers. These can be designed complementary to any given DNA sequence. With high efficiency and relative simplicity of operation, the described methodologies and strategies hence form the basis for a new supramolecular ligand system targeting double‐stranded DNA without strand invasion.
An energy‐efficient model for PPE waste management in a closed‐loop supply chain
Authors: Yadav Shikha , Kumar Mangla Sachin , Priyamvada Priyamvada , Borkar Aman , Khanna Aditi 
Published: August 2023

AbstractThe COVID‐19 crisis has significantly increased non‐decomposable personal protective equipment (PPE), such as gloves, masks, and shields. The improper disposal of these items poses a serious environmental threat. The present study explores the potential of recycling PPE to not only enhance the profitability of the supply chain but also address the environmental challenges associated with disposal. Specifically, it focuses on implementing a closed‐loop approach involving the manufacturer, the customer, and the collector. An extensive literature review on inventory models was conducted, resulting in a comprehensive data set. The numerical analysis, conducted using the Generalized Reduced Gradient Solver, validates the findings. The proposed model suggests that investing in a closed‐loop supply chain, employing an energy‐efficient approach, can effectively reduce carbon emissions at every stage of the system. This can be achieved by leveraging intelligent machinery and skilled labor to meet the growing demand for PPE while minimizing energy consumption. Furthermore, this research emphasizes the importance of implementing the reduce, reuse, and recycle (3Rs) phenomenon to manage waste effectively. This study provides valuable insights for businesses aiming to optimize waste management practices and contribute to economic‐environmental‐social sustainability.
What should I say? Online dating and disclosure experiences of adults with mental illness in long‐term romantic relationships
Authors: Stein Catherine H. , Griffith Frances J. , Rudd Melissa F. , Kalantzis Maria A. 
Published: August 2023

AbstractThe present study examined accounts of online and in‐person dating experiences from adults with mental illness who are in long‐term romantic relationships (N = 23). In focus group discussions, participants described their views of advantages and disadvantages of online dating and in‐person dating, how they constructed online dating profiles, decisions about disclosure of their mental health conditions to current romantic partners, and advice about dating for other people coping with mental illness. Overall, participants reported feeling less comfortable with online dating than in‐person dating. A majority of the sample reported that they intentionally excluded information about their mental health status from their online dating profiles. Present findings identified themes from participant accounts about disclosure of their mental illness to their romantic partners that included spontaneous or intentional disclosure, situational or circumstantial disclosure, delayed disclosure due to lack of information, and avoided disclosure. Adults' advice to others with mental illness centred on how to maintain romantic relationships. The importance of research focused on the lived experience of adults with mental illness in long‐term romantic relationships and practical implications of present findings are discussed.
Music conditioned 2D hand gesture dance generation with HGS
Authors: Zhou Dian , Liu Shiguang , Xu Qing 
Published: August 2023

AbstractIn recent years, the short video industry is booming. However, there are still many difficulties in the action generation of virtual characters. We observed that on the short video social platform, “hand gesture dance” is a very popular short video form. However, its development is limited by the professionalism of choreography. In order to solve these problems, we propose an intelligent choreography framework, which can generate new gesture sequences for unseen audio based on pairing data in the database. Our framework adopts multimodal method and obtains excellent results. In additional, we collected and produced the first and largest pair labeled hand gesture dance data set. Various experiments showed that our results not only generate smooth and rich action sequences, but also collect some semantic information contained in the audio.
Perfect apples or sustainable production?—Consumer perspectives from Germany
Authors: Hueppe Ronja , Zander Katrin 
Published: August 2023

AbstractIn recent years, environmental problems, such as resource depletion and biodiversity loss, have come to the forefront of society's attention. Consumption of fruits and vegetables from extensive production systems could decrease food loss and increase biodiversity and more sustainable resource use. However, fruits and vegetables from extensive production systems are not always of perfect external quality, and hence, rejected by consumers. To increase acceptance of imperfect fruits, this study aims to better understand consumers' perceptions of different levels of imperfections, using apples as an example. An online survey with 842 German consumers investigated associations, important apple‐buying criteria, organic apple consumption, socio‐demographics, and willingness to pay (WTP) for apples with different levels of imperfection. The latter is investigated via contingent valuation. A multiple linear regression was calculated for each level of imperfection. Results show that consumers' WTP for apples differed depending on the level of external imperfections. The majority of consumers accepted slightly imperfect apples; a noticeable share would even buy them at the same price as flawless apples. Apples with heavy imperfections were mainly accepted by consumers who had sustainable buying criteria. To increase acceptance, it is important to tell consumers that their food choice can make an impact on how apples are produced, that imperfect apples come from more sustainable production systems and are of perfect internal quality. And finally, it is important to give specific advice that buying these apples can help to increase sustainable resource use and biodiversity.
Nutraceutical Activity of Anthocyanins from the Edible Berries of Rhamnus pompana
Authors: Pacheco‐Hernández Yesenia , Lozoya‐Gloria Edmundo , Rangel‐Galván Maricruz , Varela‐Caselis Jenaro Leocadio , Villa‐Ruano Nemesio 
Published: August 2023

AbstractWe present the inhibitory properties of the R. pompana anthocyanin fraction (RPAF) and its major constituents on alpha‐glucosidase (AG), pancreatic lipase (PL), HMG‐CoA reductase, and ornithine decarboxylase (ODC). The effect of RPAF was also evaluated in ICR male mice subjected to oral glucose tolerance test (OGTT) and hypercaloric/atherogenic diet for 30 days. RP‐HPLC/MS profiling revealed that RPAF contained five major anthocyanins and induced slight inhibition on PL and HMG‐CoA reductase (IC50, 245–338 μg mL−1) whereas strong activity on AG and ODC (IC50, 130–133 μg mL−1) was observed. Kinetic studies and molecular docking with pelargonidin‐3‐O‐rutinoside (P3R) on ODC, revealed changes in Km (0.9514–0.9746 mM) and Vmax (1.96–2.32 μmol mg−1 min−1) suggesting mixed inhibition and molecular interaction with two active sites of ODC. P3R showed antiproliferative activity (IC50, 46.5 μM) and decreased polyamine accumulation in DLD‐1 cells. The results of OGTT confirmed that RPAF regulates postprandial glucose levels in diabetic animals which experienced a significant glucose depletion (30 %; p<0.001) from 30 to 120 min post‐treatment. Prolonged supplementation of RPAF caused significant decrease (p<0.001) in plasma glucose, total cholesterol, LDL‐c and triglycerides as well as significant increase (p<0.001) of HDL‐c compared with normoglycemic untreated animals.
Selecting Technologies for Sour and Ultra‐Sour Gas Treating
Authors: Spatolisano Elvira , Pellegrini Laura A. , Finocchi Antonio , de Angelis Alberto Renato 
Published: August 2023

AbstractAs the cleanest fossil fuel, natural gas plays a key role in the path towards renewables. Considering the increasing gas demand, rich CO2 and H2S gas reserves, in the past considered economically unviable, are becoming fruitful. However, the non‐conventional nature of this kind of gases, in addition to the potentially higher production cost, raises the need of new strategies for their monetization, bypassing the conventional approaches. Starting from the huge number of novel large‐scale projects for the exploitation of rich‐H2S gas fields, this paper overviews the current tendencies in sour and ultra‐sour natural gas production, focusing on the removal of sulfur‐based compounds, together with H2S and CO2. At first, available technologies for ultra‐sour gas treatment are discussed. Then, simulations of the absorption processes based on a real case‐study are carried out, in order to verify the effectiveness of the proposed alternatives for the removal of mercaptans, as well as CO2 and H2S. Results are critically analyzed, in view of providing a practical guide of industrial interest for the selection of the most suitable method.
PDGF‐C promotes cell proliferation partially via downregulating BOP1
Authors: Li Jiahui , Hu Wenjie , Zhang Ruting , Chen Wei , Li Xuri , Tang Zhongshu 
Published: August 2023

AbstractPlatelet‐derived growth factor C (PDGF‐C) is a member of PDGF/VEGF family, which is well‐known for important functions in the vascular system. It is widely reported that PDGF‐C is able to modulate cell proliferation. However, it is still not very clear about this cell modulating mechanism at the molecular level. In a screening of factors regulated by PDGF‐C protein, we fished out a factor called block of proliferation 1 (BOP1), which is a pivotal regulator of ribosome biogenesis and cell proliferation. In this study, we investigated the regulation of BOP1 by PDGF‐C and its role in modulating cell proliferation. We found that BOP1 was downregulated at both mRNA and protein levels in cells treated with PDGF‐C‐containing conditioned medium. On the other hand, BOP1 was upregulated in PDGF‐C deficient mice. Furthermore, we confirmed that overexpression of BOP1 inhibited HEK293A cell proliferation, whereas knockdown of BOP1 promoted cell proliferation. The mitogenic effect of PDGF‐C could be attenuated by downregulation of BOP1. Our results demonstrate a clear PDGF‐C–BOP1 signaling that modulates cell proliferation.
Fibromyalgia: Could hyperbaric oxygen therapy make the difference? Our experience
Authors: Cracchiolo Andrea Neville , Palma Daniela Maria , Genco Fabio , Palmeri Marco , Teresi Alessandra , Zummo Leila , Gigliuto Carmelo , Saporito Erik Flavio Giuseppe , Ferruzza Angela , Piccoli Tommaso 
Published: August 2023

Key Clinical MessageFibromyalgia is a rare disease, difficult to diagnose and to treat. We think that hyperbaric oxygen therapy could improve its signs and symptoms although more evidences have to be accumulated.
Misdiagnosis of persistent left superior vena cava with unroofed coronary sinus as a coronary sinus‐type atrial septal defect
Authors: Al‐Dairy Alwaleed , Ahmad Reem , Hasan Rawan 
Published: August 2023

Key Clinical MessageAwareness of persistent left superior vena cava (PLSVC) with unroofed coronary sinus is crucial. Pre‐ and perioperative evaluation of this association is necessary for surgical plan. Creating an intra‐atrial tunnel to divert LSVC to right atrium without obstructing the mitral valve or the pulmonary veins is the safe surgical approach.AbstractUnroofed coronary sinus syndrome is a rare congenital heart defect representing less than 1% of all atrial septal defect (ASD) types, and may be associated with persistent left superior vena cava (PLSVC) which may be missed during preoperative diagnosis. Herein, we present a case of a 2‐year‐old patient who underwent an operation for repair of a coronary sinus‐type ASD; however, PLSVC was detected intraoperatively. An antra‐atrial tunnel has created to divert the flow of PLSVC into the right atrium along with the repair of the ASD.
Black hairy tongue after alprazolam intake
Authors: Jiang Long , Li Kun , Tan Lu , Tang Xiangdong 
Published: August 2023

Key Clinical MessageA 31‐year‐old female with a diagnosis of bipolar disorder developed black hairy tongue after alprazolam therapy. Her symptom resolved 10 days after the cessation of alprazolam.AbstractAlprazolam is a widely used antidepressant and antianxiety drug. Mild to moderate side effect of alprazolam was commonly seen, including lethargy, dizziness, headache, dry mouth, nausea, fatigue, constipation, and blurred vision. In this case, we reported a patient developed black hairy tongue after alprazolam intake, and her symptom resolved after 10‐day discontinuation of alprazolam. This rare adverse event should be of concern to clinicians. This is the first paper to report an alprazolam‐induced BHT. This rare side effect of alprazolam should be concern of clinicians; we hope our report will promote the understand of BHT and acknowledge clinicians of this rare side effect of alprazolam.
Optimum Yield of Empty Fruit Bunches Cellulose Nanofibers by Deep Eutectic Solvent and Ultrasonication
Authors: Jafri Nur Huda Syazwani Binti , Jimat Dzun Noraini , Wan Nawawi Wan Mohd Fazli , Ahmad Nor Yusilawati , Amid Azura 
Published: August 2023

AbstractCellulose nanofibers (CNFs) are extensively utilized as affordable, renewable materials. The conventional technique for making CNFs is time‐consuming, requires hazardous toxic chemicals, and consumes enormous amounts of energy. CNFs from empty fruit bunches (EFB) were produced via deep eutectic solvent (DES) and ultrasonication. The DES treatment conditions were optimized using the central composite design (CCD) approach of response surface methodology (RSM). Analysis of variance (ANOVA) revealed that the reaction time, DES molar ratio, and temperature were all significant variables. The experimental results closely correspond to the theoretical model of CNFs yield. X‐ray diffraction (XRD) studies demonstrated that the crystallinity index of the CNFs increased significantly after sonication. It could be stated that DES treatment and ultrasonication were effective ways to successfully generate CNFs from EFB. This study may serve as foundation for high‐yield, industrial‐scale synthesis of nanocellulose using DES treatment.
Total Synthesis of Syringin and Its Natural Analogues via C—C Bond Activation of Aryl Ketones†
Authors: Wang Zhen‐Yu , Sun Yi , Sun Guo‐Dong , Xu Hui , Dai Hui‐Xiong 
Published: August 2023

Comprehensive SummarySyringin is found in the root of Acanthopanax senticosus (Rupr. Maxim.) Harms and belongs to the lignin chemical compound with many biological activities. In this study, we employed commercially available starting materials and accomplished the total synthesis of syringin in 5 steps with an overall yield of 58%. Palladium‐catalyzed C(O)–C bond activation and subsequent cross coupling reaction is the key to construct syringin and its natural analogues.
Review of carbon dioxide mineralization of magnesium‐containing materials
Authors: Li Jia , Luo Mingzhi , Wang Kun , Li Gaomiao , Zhang Guoquan 
Published: August 2023

AbstractThe increasing utilization of fossil fuels and industrial activities has resulted in a surge of CO2 emissions, which have significantly impacted global climate change. Carbon capture and utilization technologies offer a promising solution to decrease atmospheric CO2 concentrations and convert CO2 into valuable products. This study focuses on the capture and storage of CO2 through the mineralization of magnesium‐containing materials. The analysis encompasses the mineralization process of solid and liquid minerals, the various mineralization processes of magnesium‐containing minerals categorized as direct and indirect mineralization, and the latest research advancements in magnesium‐containing minerals. Brine and seawater from salt lakes are considered the most appropriate materials for mineralization due to their abundance and the simplicity of the process compared to solid mineralization. This paper analyzes the impact of temperature, impurity ions, additives, and microorganisms on the process of magnesium carbonate synthesis crystallization. The use of magnesium‐containing materials for carbon dioxide sequestration can effectively reduce carbon emission. The review offers guidance on carbon dioxide mineralization and explores the potential applications of magnesium mineralization.
Nonverbal face‐to‐face interactions in macaques and humans: A translational pilot study
Authors: Dettmer Amanda M. , Bartz Cody , Rutherford Helena J. V. 
Published: August 2023

AbstractHuman and nonhuman primate mother–infant dyads engage in face‐to‐face interactions critical for optimal infant development. In semi‐free‐ranging rhesus macaques (Macaca mulatta), maternal primiparity and infant sex influence the expression of nonverbal face‐to‐face mother–infant interactions. However, whether similar patterns of variation exist in laboratory‐housed macaques or human mothers is not well understood. Comparing both species would yield information regarding the translational validity of macaques to humans in this important social/developmental domain. In this pilot study, we first compared semi‐free‐ranging (n = 39) and laboratory‐housed (n = 20) macaques, finding that laboratory‐housed dyads, first‐time mothers, and mothers of sons engaged in higher rates of face‐to‐face interactions regardless of housing. After translating the nonhuman primate coding scheme for use in a small but diverse group of human mother–infant dyads (N = 27; 44.4% African American, 18.5% American Indian, 7.4% Asian/Asian American, and 29.6% White), we found that, like macaques, human mothers of sons engaged in more face‐to‐face interactions; however, experienced (vs. first‐time) mothers engaged in more interactions. Macaques and humans also engaged in species–specific interactions with their infants. We conclude that components of caregiver–infant nonverbal face‐to‐face interactions are translatable across human and nonhuman primate species and represent an exciting avenue for future caregiving work.
Needle‐type pressure sensor with silicone oil and parylene membrane inside for minimally invasive measurement
Authors: Kishimoto Takuto , Agetsuma Masakazu , Hoshino Ayuko , Takahashi Hidetoshi 
Published: August 2023

AbstractThis paper addresses a pressure sensor for body pressure measurement. Many pressure sensors have been developed for disease treatment in the medical field. However, these sensors require inserting electronic components and other sensor elements via surgical operations, so the measurement physically burdens patients. Hence, we proposed a needle‐type pressure sensor using MEMS (Micro Electro Mechanical Systems) cantilever. The sensor has a needle part with a thin membrane on the tip and is filled with incompressible fluid inside. The fractional resistance of the built‐in piezoresistive cantilever varies according to the pressure change applied to the needle tip. We can measure body fluid pressure with minimal surgery by inserting a simple needle into the target organ. Because the fabricated sensor responded to pseudo‐body pressure changes, it was suggested that the fabricated needle‐type pressure sensor could detect pressure inside the body.