bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRISPR-Cas9: The Future of Precision Genome Engineering
Authors: Akram Tariq Muhammad 
Published: July 2023

CRISPR-Cas9, a revolutionary gene-editing tool, has garnered significant attention in the scientific community and beyond. This innovative technology holds immense promise for precision genome engineering, enabling scientists to modify DNA with unprecedented accuracy. The potential applications of CRISPR-Cas9 are vast, ranging from treating genetic disorders to enhancing agricultural crops. As we delve into the era of personalized medicine and genetic advancements, CRISPR-Cas9 emerges as a game-changer in the field of biotechnology. At the core of CRISPR-Cas9 lies its ability to precisely target and edit specific genes within the genome. This powerful tool utilizes RNA molecules as guides to direct the Cas9 enzyme to the desired DNA sequence, where it makes precise cuts. By introducing modifications or repairs to the DNA at these targeted sites, researchers can potentially correct genetic mutations responsible for diseases. The ability to edit the human genome with such precision offers hope for treating previously incurable genetic disorders and improving patient outcomes.
Moreover, CRISPR-Cas9 has implications beyond human health. It has the potential to revolutionize agriculture by enhancing crop resistance to pests, improving yields, and reducing the need for harmful pesticides. By modifying specific genes in plants, scientists can develop crops that are more resilient to environmental stressors, ultimately contributing to global food security and sustainability efforts. Despite its immense potential, CRISPR-Cas9 also raises ethical considerations and concerns. The technology's power to edit the human germline raises questions about the potential for unintended consequences and the need for responsible use. The scientific community and policymakers must engage in thoughtful discussions and establish guidelines to ensure the ethical and responsible implementation of CRISPR-Cas9.
CRISPR-Cas9 represents a landmark advancement in precision genome engineering, offering unprecedented opportunities to reshape the future of healthcare and agriculture. By harnessing its potential, we can envision a world where previously untreatable genetic diseases are curable, crops are more resilient and productive, and our understanding of the genetic basis of life is deepened. However, as we embrace the future of CRISPR-Cas9, it is crucial to navigate the ethical implications and ensure responsible use to maximize the benefits and minimize potential risks. The potential of this transformative technology is immense, and its impact on society will be profound.
BANKA DENETİM RAPORLARININ YETERLİLİĞİ VE BEKLENTİ BOŞLUĞU
Authors: KARTAL Fikret 
Published: July 2023

Ekonomik krizlerin negatif etkilerini azaltmak amacıyla bankacılık otoriteleri bazı tedbirler almakta
ve bankaların görünümü ile doğrudan ilişkili olan kredi sınıflandırması, sorunlu krediler için ayrılan
karşılıklar, sermaye yeterliliği, zorunlu karşılıklar ve likidite konularında raporlama standartlarını
değiştirmektedir. Bu değişiklikler bankaların finansal verileri üzerinde büyük etki doğurmakta ve
bundan dolayı bağımsız denetim raporları daha fazla önem kazanmaktadır. Yatırımcılar denetlenen
hakkında daha fazla bilgi sahibi olmak amacıyla denetim raporlarının ilave bilgi ve analizler içermesini
beklemektedir. Bu çalışma, beklenti boşluğu ve özellikle performans açığı bağlamında, denetim
raporlarının etkinliği ve yeterliliğini değerlendirmektedir. Çalışmanın işaret ettiği sonuçlar, kredi
kalitesi ve risk bileşenleri alanlarında denetim raporlarının denetimin amaçlarını ve yatırımcıların
ihtiyaçlarını karşılayamadığını göstermektedir.
TÜRKİYE’DE İLİŞKİLİ TARAF İŞLEMLERİNİN FİRMA DEĞERİ ÜZERİNE ETKİLERİ
Authors: KUTLUCAN ÖZÜLKEN Ayça , AYANOĞLU Yıldız 
Published: July 2023

Günümüzde işletmelerin ilişkili taraflarıyla gerçekleştirdikleri işlemler kurumsal yönetişim ve
şeffaflık konularında önem arz etmektedir. Yakın tarihlerde ABD ve Avrupa’da yaşanan muhasebe
skandalları sonrasında bu işlemlerin firma değerine etkisi güncel yazında önemli bir yer edinmektedir.
Bu bağlamda, bu çalışmanın amacı Türkiye’de şirketlerin ilişkili taraflarla yaptığı işlemlerin firma
değerine etkisini incelemektir. Çalışma kapsamında 2013-2022 yılları arasında kurumsal yönetim
endeksinde yer alan 31 şirket örneklem olarak seçilmiştir. Panel veri analizi yöntemleri kullanılarak
yapılan araştırmada Türkiye’deki şirketlerin gerçekleştirdiği ilişkili taraf işlemlerinin firma değerine
istatistiksel olarak anlamlı bir etki gösterdiği görülmüştür. İlişkili taraf işlemlerinin türü bazında
yapılan analizler sonucunda şirketlerin ilişkili taraflarından yaptıkları alımların firma değerine
olumsuz yansıdığı, öte yandan ilişkili taraflarla girilen borç ve alacak işlemlerinin ise firma değerine
pozitif etki ettiği gözlemlenmiştir. Şirketlerin ilişkili taraflarla yürüttükleri işlemlerin, etkin işlemler
teoremi çerçevesinde, firmaların verimliliğini ve performansını artırdığı, dolayısıyla da firma değerini
artırdığı sonucuna ulaşılmıştır. Çalışmanın bulgularının karar alıcılara ve politika yapıcılara karar
aşamalarında önemli katkılar sağlayacağı öngörülmektedir.
Libro de Memorias de los Congresos Organizados y co-organizados por LATAM
Authors: Red de Investigadores Latinoamericana  
Published: July 2023

En este libro de resúmenes, les presentamos una selección de las investigaciones más destacadas presentadas en el evento. Durante este congreso, expertos y científicos de diversas disciplinas se han reunido para compartir conocimientos, debatir ideas y promover la colaboración científica en América Latina.
Los resúmenes aquí recopilados reflejan la diversidad y el alcance de los estudios presentados en el congreso. Desde avances en la medicina y la biotecnología hasta investigaciones en ingeniería, ciencias sociales, medio ambiente y mucho más, cada resumen representa un valioso aporte al conocimiento científico actual.
A Formulasi ‘Zilang Tea” Teh Herbal Peningkat Imunitas Tubuh Berbahan Jahe Merah (Zingiber officinale var. Rubrum) dan Bunga Telang (Clitoria ternatea)
Authors: Wijayanti Agustin 
Published: July 2023

Zilang Tea adalah the herbal yang diformulasi oleh Tim PKM Kewirausahaan Politeknik Kesehatan Bhakti Setya Indonesia. The herbal ini berupa the celup yang berbahan dasar bunga telang dan jahe merah yang telah dikeringkan. Tujuan formulasi the herbal ini adalah untuk membuat sediaan the herbal yang praktis yang mengandung senyawa aktif untuk meningkatkan imunitas tubuh.
Proses pembuatan the herbal ini dimulai dari sortasi, pencucian, perajangan hingga pengeringan dengan mengikuti pertunjuk pengeringan simplisia dari penelitian-penelitian sebelumnya. Selanjutnya dilakukan penghalusan dari simplisia. Simplisia yang telah halus selanjutnya ditimbang dan dicampur sesuai dengan formula yang terpilih dan selanjutnya dikemas.
Produk the herbal yang telah dikemas dapat dikonsumsi dengan cara menyeduh didalam air panas. Senyawa aktif yang berupa Vit C, berbagai jenis flavonoid yang terlalrut didalamnya dapat memiliki khasiat sebagai imunostimulan untuk meningkatkan aktivitas sistem imun melawan virus, bakteri dan mikroba-mikroba lainnya. Hasil seduhan teh herbal berwarna ungu seperti warna bunga telang dan berasa agak pedas seperti jahe. Kesimpulan dari formulasi ini adalah pemanfaatan bunga telang dan jahe merah untuk dijadikan teh herbal celup sebagai minuman kesehatan potensial dimanfaatkan dan dikembangkan oleh masyarakat luas.
Gambaran Kepuasan Pendonor Darah terhadap Pelayanan Petugas Seleksi Donor Darah di UDD PMI Kota Yogyakarta Tahun 2022
Authors: Rosyidah Rudina azimata 
Published: July 2023

Kepuasan pendonor adalah perasaan senang atau kecewa seseorang setelah membandingkan pelayanan petugas yang diberikan yang sesuai dengan harapannya. Kepuasan pendonor dalam kaitannya dengan pelayanan petugas seleksi donor dapat diukur berdasarkan 5 dimensi yaitu cepat tanggap (responsiveness), kehandalan (reliability), jaminan (assurance), perhatian (emphaty), dan penampilan fisik (tangible). Tujuan dilakukan penelitian ini adalah untuk menilai kepuasan pendonor darah terhadap pelayanan petugas seleksi donor berdasarkan dimensi cepat tanggap (responsiveness), kehandalan (reliability), jaminan (assurance), perhatian (emphaty), dan penampilan fisik (tangible).
Penelitian ini merupakan jenis penelitian deskriptif yaitu menggambarkan kepuasan pendonor darah terhadap pelayanan petugas seleksi donor di UDD PMI Kota Yogyakarta Tahun 2022. Sampel penelitian adalah pendonor darah di UDD PMI Kota Yogyakarta dengan metode accidental sampling dengan jumlah sampel 100 responden dan analisis data menggunakan program komputer dengan analisis univariat.
Berdasarkan data penelitian yang diperoleh bahwa didapatkan mayoritas hasil karakteristik pendonor darah berdasarkan jenis kelamin adalah pria yaitu sebanyak 75 orang (75%), berdasarkan umur pada kategori dewasa awal yaitu 25-44 tahun sebanyak 40 orang (40%), berdasarkan pendidikan terakhir adalah S1/S2/S3 sebanyak 48 orang (48%), dan berdasarkan pekerjaan adalah pegawai swasta sebanyak 31 orang (31%). Hasil penelitian tentang kepuasan pendonor darah terhadap pelayanan petugas seleksi donor di UDD PMI Kota Yogyakarta tahun 2022 didapatkan hasil bahwa persepsi kepuasan pendonor darah berdasarkan dimensi cepat tanggap (responsiveness) 90,06%, kehandalan (reliability) 91,54%, jaminan (assurance) 88,08%, perhatian (emphaty) 89,66%, dan penampilan fisik (tangible) 68,93%. Sehingga persentase rata-rata kepuasan pendonor darah terhadap petugas seleksi donor di UDD PMI Kota Yogyakarta tahun 2022 secara keseluruhan sebesar 85,80% dengan klasifikasi sangat puas.
THE ROLE OF COGNITIVE PROCESSES IN THE DEVELOPMENT OF MENTAL DISORDERS
Authors: Коваленко Ольга Олеговна 
Published: July 2023

Когнитивные процессы играют решающую роль в развитии и поддержании психических расстройств. В данной статье представлен обзор современных исследований роли когнитивных процессов в психологических расстройствах. Мы начнем с определения когнитивных процессов и различных типов когнитивных искажений. Затем мы обсудим, как когнитивные процессы могут влиять на развитие различных психологических расстройств, включая тревожные расстройства, депрессию, расстройства пищевого поведения и расстройства, связанные со злоупотреблением психоактивными веществами. Наконец, мы обсудим последствия этого исследования для клинической практики и будущие направления исследований в этой области.
Cognitive processes play a crucial role in the development and maintenance of mental disorders. This article provides an overview of current research on the role of cognitive processes in psychological disorders. We will start by defining cognitive processes and different types of cognitive distortions. Then we will discuss how cognitive processes can influence the development of various psychological disorders, including anxiety disorders, depression, eating disorders and substance abuse disorders. Finally, we will discuss the implications of this study for clinical practice and future research directions in this area.
ENSURING THE SAFETY OF TRAFFIC OF VESSELS AND CONSTRUCTIONS IN SHALLOW WATER CONDITIONS ON INLAND WATERWAYS
Authors: Хвостов Роман Сергеевич , Романова Екатерина Анатольевна 
Published: July 2023

Статья посвящена рассмотрению вопросов, связанных с возможностями обеспечения безопасности движения судов и составов в условиях мелководья на внутренних водных путях. Особое внимание уделено перспективам внедрения и широкого использования средств активного управления на базе современных информационных систем ECDIS, позволяющих отображать на электронных картах актуальную навигационную информацию.
The article is devoted to the consideration of topical issues related to the possibilities of ensuring the safety of the movement of ships and trains in shallow water conditions on inland waterways. Special attention is paid to the prospects for the introduction and widespread use of active management tools based on modern ECDIS information systems, which allow displaying up-to-date navigation information on electronic charts.
Green Innovation, Pressure, Green Training, and Green Manufacturing: Empirical evidence from the Indian apparel export industry
Authors: Jain Sweta , Kalapurackal Jacob Joseph 
Published: July 2023

The fact that garment companies contribute to the fast declining environmental conditions in emerging nations and the dearth of sufficient studies that may assist manufacturing companies in reversing this trend, this empirical study of Indian garment manufacturing export units aims to investigate the relationships between Pressure, Green manufacturing, Green Training, and Green Innovation Additionally, it investigates the mediating impacts of green innovation and green training while assessing the impact of Pressure on green manufacturing The research data is collected by preparing questionnaires for garment manufacturing firms in Karnataka Data was acquired by a survey method. Hypotheses were tested using Smart PLS 4.0. The findings indicate that green training, green innovation, and pressures significantly and positively impact green manufacturing. However, green innovation has the most significant impact, followed by green training and Pressure. According to the findings, there is a partial positive significant mediation of Pressure between Green training and GM, a partial positive significant mediation of green innovation between Green training and GM, and a partial positive significant mediation of Pressure between Green innovation and Green Manufacturing. Furthermore, the R2 value of GM is high, exhibiting a 78.2% impact. The investigation results indicate that all the proposed hypotheses have been validated, which adds to the existing literature. The results of this empirical study, which is the first to examine the implications of Pressure, Green Training, and Green Innovation variables on adopting GM practices specifically for the Indian garment manufacturing export industry, will be equally helpful to researchers and practitioners to combat India's environmental problems.
Comparative Molecular Genetic Characteristics of <i>Mycobacterium tuberculosis</i> Cultures Isolated in the European Part of the Russian Federation in 1998–2003 and 2016–2021
Authors: Andreevskaya S. N. , Larionova E. E. , Kiseleva E. A. , Chernousova L. N. , Ergeshov A. Е. 
Published: July 2023

The objective: to evaluate changes in detection frequency of Mycobacterium tuberculosis of the main phylogenetic lines with various genetic determinants of resistance to rifampicin, isoniazid and fluoroquinolones in 1998–2003 and 2016–2021.Subjects and Methods. 965 mycobacterial cultures were studied, those cultures were isolated from pulmonary tuberculosis patients in 1998–2003 and 2016–2021. The spoligotypes of isolated Mycobacterium tuberculosis cultures and presence of gene mutations associated with resistance to isoniazid, rifampicin, and fluoroquinolones were determined.Results. In 2016–2021 versus 1998–2003, the incidence of Beijing subline increased from 50,72% to 64,60%. Within Euro-American line, the detection frequency of subline LAM9 decreased (from 40,00% to 14,81%), while the detection frequency of sublineT1 increased (from 27,11% to 41,36%). Mycobacterium tuberculosis with MDR genotype rpoB531_Ser->Leu + katG315_Ser-> Thr [1] was selected. Mycobacterium tuberculosis with genotypic resistance to fluoroquinolones was detected only in cultures of 2016–2021, and Mycobacterium tuberculosis with preXDR genotype was significantly more common in Beijing subline compared to Euro-American line (21,67% vs. 3,73%, p <0,05).
Genetic Determinants of Rifampicin Resistance of Mycobacterium tuberculosis not Included in the Russian Molecular Genetic Test Systems
Authors: Mazurina E. A. , Umpeleva T. V. , Golubeva L. A. , Lavrenchuk L. S. , Vakhrusheva D. V. , Vasilyeva I. A. 
Published: July 2023

The objective: to study the genetic determinants of rifampicin resistance of Mycobacterium tuberculosis by sequencing the RRDR rpoB gene.Subjects and Methods. The study included 651 M. tuberculosis isolates that were tested for drug suceptibility (DST) by genotypic methods (gDST) TB-TEST (BIOCHIP-IMB, Russia), and Amplitube-MDR-RV (NPK Sintol, Russia) and phenotypic methods (phDST): the absolute concentration method, BACTEC MGIT 960 system, and Sensititre Myco TB kit. Sanger RRDR sequencing of the rpoB gene was performed for 20 isolates with discrepancies in the results of phDST and gDST.Results. As a result of sequencing, two variants of mutations in the RRDR region of the rpoB gene were found, which were not detected by TB-TEST and Amblitub MDR-RV test systems, however were strongly associated with rifampicin resistance of Mycobacterium tuberculosis. The most common variant was the insertion of three nucleotides (TTC) encoding the amino acid phenylalanine at position 434 of the codon (1296-1300insTTC).
REMAJA DAN HUBUNGAN SEKS PRA NIKAH
Authors: Nur Lutfiana Wike , Widhiyaningrum Tial , Risko Faristiana Andhita 
Published: July 2023

Mengetahui kenakalan remaja ataupun tentang perilaku seks pranikah di kalangan remaja Desa x Kabupaten Ngawi dan mendreskripsikan secara mendalam tentang perilaku seks pranikah di kalangan remaja di Desa x Kabupaten Ngawi. Sumber data diperoleh melalui dokumentasi maupun wawancara dengan masyarakat sekitar. Perilaku seks pranikah pada remaja merupakan suatu fenomena yang semakin marak terjadi, tak terkecuali di Desa x Kabupaten Ngawi. Faktor-faktor penyebab munculnya perilaku seks pranikah berdasarkan hasil penelitian diantaranya adalah 1) Kurangnya pengawasan keluarga terhadap anak 2) Pengaruh media yang semakin berkembang 3) Rendahnya pendidikan nilai agama. Upaya pencegahan perilaku seks bebas dapat dilakukan dengan yang pertama yaitu melalui diri kita sendiri yang kedua yaitu melalui keluarga dan yang ketiga yaitu melalui lingkungan yang dimana kita harus bisa memilah anttar teman yang baik maupun teman yang buruk dalam berperilaku dan kita juga harus memiliki kegiatan diluar yang lebih baik semisal dalam sekolah kita mengikuti ekstrakulikuler.
PENGARUH KONFLIK KERJA DAN BEBAN KERJA TERHADAP KINERJA KARYAWAN PADA PT. MUJUR TIMBER SIBOLGA
Authors: Giot Marito Simatupang  , Mansur Tanjung  , Nurainun Hasibuan  
Published: July 2023

Writing this thesis aims to determine the effect of work conflict and workload on employee performance at PT. Lucky Timber Sibolga. The problem encountered in this study is the lack of a sense of mutual support in doing work as a team.
The formulation of the problem in this study is whether there is an influence of work conflict and workload on employee performance at PT. Lucky Timber Sibolga? While the purpose of this study was to find out whether there is an influence of work conflict and workload on employee performance at PT. Lucky Timber Sibolga? The hypothesis put forward is that there is an influence of work conflict and workload on employee performance at PT. Lucky Timber Sibolga. The population in this study amounted to 525 people consisting of employees and contract employees, the sample in this study were 84 people. The data collection technique was carried out by distributing questionnaires. The data analysis technique used is quantitative analysis.
The results of the study found that work conflict and workload can affect employee performance at PT. It is known that Timber Sibolga has a coefficient of determination (R Square) of 0.605. Work conflict and workload together or simultaneously have a positive and significant effect on employee performance at PT. Lucky Timber Sibolga. Where is the Fcount > Ftable value (61.931> 3.11). Partially, work conflict has a positive and significant effect on employee performance at PT. Lucky Timber Sibolga. Where the value of tcount = (5.461) is greater than the value of ttable (1.989), Partially the most dominant workload affects performance, meaning that the workload variable is more decisive in improving employee performance compared to work conflict. Where the value of tcount = (8.886) > ttable value (1.989 ). Multiple linear regression equation Y = 11.315 + 0.315X1 + 0.511X2 employee performance shows a positive direction. It is recommended for companies to always try to control conflicts that occur in employees, namely by providing solutions to every problem that occurs in employees.
PENGARUH KETERLIBATAN KERJA DAN PEMBAGIAN KERJA TERHADAP KINERJA PEGAWAI PADA PEMERINTAHAN KECAMATAN SIBOLGA KOTA
Authors: Harmoko W Purba  , Mansur Tanjung  , Yacub Hutabarat  
Published: July 2023

The organization is a means or tool for achieving goals, as a vehicle (vehicle) for the activities of workers who work together in their efforts to achieve goals. These goals certainly differ from one another, for example, they can be in the form of social services, education improvement, career development and so on. Every activity carried out by an organization certainly requires various resources, such as capital, materials, and machinery. Existing resources will be meaningless if not managed properly. To manage it requires other resources, namely, human resources.
The formulation of the problem in this study is the formulation of whether work involvement and division of labor jointly affect the performance of employees in the Sibolga Kota District Government? This study aims to determine how much influence work involvement and division of labor have on employee performance in the Sibolga Kota District Government. The temporary hypothesis is that work involvement and division of labor have a joint effect on the performance of employees in the Sibolga Kota District Government. The population is 85 people and is used as a sample. Data collection techniques using library research and field research. The results of the study show that the variables of work involvement and division of labor can affect the performance of employees in the Sibolga Kota District Government by 54.2%. Work involvement and division of labor jointly or simultaneously have a positive and significant effect on the performance of employees in the Sibolga Kota District Government. Where the Fcount value is greater than the Ftable value (38.510 > 3.11). Partially, work involvement has a positive and significant effect on employee performance in the Sibolga Kota District Government. Where the value of tcount = (2.373) is greater than the value of ttable (1.992), Partially the most dominant division of labor affects employee performance, meaning that the variable of division of labor is more decisive in improving employee performance compared to work involvement. Where the value of tcount = (4.453) is greater than the value of ttable (1.995).