bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of medication adherence and medication beliefs and their relation with quality of life in osteoporotic patients with and without vertebral fractures: a path analysis
Authors: Erdem Sultanoğlu Tuba , Ataoğlu Safinaz 
Published: August 2023

Abstract
Background
Osteoporosis (OP) is a public health problem that causes morbidity and mortality with various complications, especially fractures, negatively affects quality of life (QoL) and creates an economic burden on society. The aim of this study was to investigate the relationships among medication adherence, medication beliefs, QoL in Turkish patients with OP.

Results
The Medication Adherence Report Scale (MARS) total score was 17 in those with vertebral fractures and 18 in those without vertebral fractures. The total Quality of Life Questionnaire of the European Foundation for Osteoporosis (Qualeffo-41) score was 48.7 in those with vertebral fractures and 35.1 in those without vertebral fractures. Visual analog scale (VAS) of pain scores showed a moderate correlation with every domain of the Qualeffo-41 scores (r = 0.401, r = 0.412, r = 0.391, r = 0.402, r = 0.380, r = 0.387 respectively, P = < 0.001). MARS total score, Beliefs about Medicines Questionnaire (BMQ), and Qualeffo-41 parameters were compared between patients with osteoporotic fractures and without fractures. In patients with a vertebral fracture, the patients Qualeffo-41 scores were higher with every domain and their QoL was more impaired (p < 0.001); but there were no significant differences between patients with osteoporotic fractures and without fractures in terms of MARS total score and BMQ domains. The pathway analysis results showed that general beliefs about drugs is associated with the physical function and social function of statistically significant and general overuse is associated with the pain (β = 1.781; p < 0.001), and general health (β = 1,832; p = 0.039). However, self-reported medication adherence and specific beliefs is not associated with the pain, physical function, social function, general health, and mental function (p > 0.05) of statistically significant.

Conclusions
Enhancing positive medication beliefs are a promising approach to improve medication adherence, and in turn, improved diseases self management and better QoL, in OP patients.
People’s perspectives on heritage conservation and tourism development: a case study of Varanasi
Authors: Pati Ananya , Husain Mujahid 
Published: August 2023

AbstractThe conservation of heritage and heritage-based tourism are interrelated activities in which the development in one can lead to the growth of the other and vice versa. In recent years, people have become increasingly aware of the importance of heritage and the necessity of its conservation. People’s knowledge and preservation of their roots and emotional attachments to traditions and places are beneficial for heritage conservation activities. Heritage places are also considered a growth point for the tourism industry that supports small- and medium-scale industries as well as numerous cottage industries. However, with the development of tourism and related industries in heritage areas, the local community may face difficulties in performing their day-to-day activities in the area. In many cases, local communities need to relocate and people must leave their residences due to the demand for tourism development. A case study of Varanasi City was conducted to obtain a detailed understanding of the impact of a recent tourism development programme (the Kashi Vishwanath Corridor Project) and people’s perception of it through a review of newspaper articles. It was found that people had mixed reactions regarding the development programme. The immediate residents of the area who were directly affected by the process in terms of emotional, economic and social loss were opposed to the project, while tourists and other residents of the city were pleased with the development activities. This paper attempts to identify the changes that occurred in the area due to the project and to capture people’s perspectives regarding the corridor project of Varanasi.
Long-term Survival From Breast Cancer Brain Metastases in the Era of Modern Systemic Therapies
Authors: Mashiach Elad , Alzate Juan Diego , De Nigris Vasconcellos Fernando , Bernstein Kenneth , Donahue Bernadine R. , Schnurman Zane , Gurewitz Jason , Rotman Lauren E. , Adams Sylvia , Meyers Marleen , Oratz Ruth , Novik Yelena , Kwa Maryann J. , Silverman Joshua S. , Sulman Erik P. , Golfinos John G. , Kondziolka Douglas 
Published: August 2023

BACKGROUND AND OBJECTIVES:
Median survival for all patients with breast cancer with brain metastases (BCBMs) has increased in the era of targeted therapy (TT) and with improved local control of intracranial tumors using stereotactic radiosurgery (SRS) and surgical resection. However, detailed characterization of the patients with long-term survival in the past 5 years remains sparse. The aim of this article is to characterize patients with BCBM who achieved long-term survival and identify factors associated with the uniquely better outcomes and to find predictors of mortality for patients with BCBM.

METHODS:
We reviewed 190 patients with breast cancer with 931 brain tumors receiving SRS who were followed at our institution with prospective data collection between 2012 and 2022. We analyzed clinical, molecular, and imaging data to assess relationship to outcomes and tumor control.

RESULTS:
The median overall survival from initial SRS and from breast cancer diagnosis was 25 months (95% CI 19-31 months) and 130 months (95% CI 100-160 months), respectively. Sixteen patients (17%) achieved long-term survival (survival ≥5 years from SRS), 9 of whom are still alive. Predictors of long-term survival included HER2+ status (P = .041) and treatment with TT (P = .046). A limited number of patients (11%) died of central nervous system (CNS) causes. A predictor of CNS-related death was the development of leptomeningeal disease after SRS (P = .025), whereas predictors of non-CNS death included extracranial metastases at first SRS (P = .017), triple-negative breast cancer (P = .002), a Karnofsky Performance Status of <80 at first SRS (P = .002), and active systemic disease at last follow-up (P = .001). Only 13% of patients eventually needed whole brain radiotherapy. Among the long-term survivors, none died of CNS progression.

CONCLUSION:
Patients with BCBM can achieve long-term survival. The use of TT and HER2+ disease are associated with long-term survival. The primary cause of death was extracranial disease progression, and none of the patients living ≥5 years died of CNS-related disease.
Ketamine infiltration improves analgesia after thyroid surgery
Authors: Sellami Moncef , Zouche Imen , Ben Ayed Mariam , Bouhali Maroua , Ben Ayed Khadija , Ktata Salma , Hammami Boutheina , Chaabouni Mohamed Amine , Charfeddine Ilhem 
Published: August 2023

Background: Postoperative pain increases the risk of postoperative complications and may predispose patients to chronic post-surgical pain. This study aims to evaluate the impact of ketamine wound infiltration versus placebo at the end of thyroid surgery on postoperative pain and analgesic requirements. Methods: In this randomized controlled trial, we prospectively studied patients who underwent thyroid surgery. Patients were randomized into two groups: group S, where local infiltration was performed using 10 ml of a physiological saline solution; and group K, where 10 ml of a solution containing 2 mg/kg ketamine was infiltrated. Standardized thyroidectomies were performed in the 2 groups. Pain perception was measured using a visual analog scale (VAS) every 10 minutes in the post-anesthetic care unit (PACU) for 2 hours and thereafter every 6 hours during the first 24 hours. The opioid requirement in the PACU was evaluated. A comparison between the 2 groups was carried out. Results: Postoperatively, the mean VAS was higher in group S compared to group K during all PACU stay periods and the first 24 hours. Pain scores during swallowing were significantly lower for group K in the PACU at 0, 10, and 20 minutes. The mean morphine consumption in the PACU was 0.71 mg and 0 mg respectively in group S and group K (p=0.03). The incidence of nausea and vomiting was similar in both groups. Conclusions: Ketamine wound infiltration is an efficient modality to reduce postoperative opioid consumption compared to a placebo after thyroid surgery.
Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial
Authors: Carrard Justin , Angst Thomas , Weber Nadia , Bienvenue Joëlle , Infanger Denis , Streese Lukas , Hinrichs Timo , Croci Ilaria , Schmied Christian , Gallart-Ayala Hector , Höchsmann Christoph , Koehler Karsten , Hanssen Henner , Ivanisevic Julijana , Schmidt-Trucksäss Arno 
Published: August 2023

Introduction: Growing scientific evidence indicates that sphingolipids predict cardiometabolic risk, independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, it remains largely unknown if and how exercise, a simple, low-cost, and patient-empowering modality to optimise cardiometabolic health, influences sphingolipid levels. The SphingoHIIT study aims to assess the response of circulating sphingolipid species to a single session of high-intensity interval training (HIIT). Methods: This single-centre randomised controlled trial (RCT) will last 11 days per participant and aim to include 32 young and healthy individuals aged 20-29 (50% females). Participants will be randomly allocated to the HIIT (n= 16) or control groups (physical rest, n= 16). Participants will self-sample fasted dried blood spots for three consecutive days before the intervention (HIIT versus rest) to determine baseline sphingolipid levels. Dried blood spots will also be collected at five time points (2, 15, 30, 60min, and 24h) following the intervention (HIIT versus rest). To minimise the dietary influence, participants will receive a standardised diet for four days, starting 24 hours before the first dried blood sampling. For females, interventions will be timed to fall within the early follicular phase to minimise the menstrual cycle's influence on sphingolipid levels. Finally, physical activity will be monitored for the whole study duration using a wrist accelerometer. Ethics and dissemination: The Ethics Committee of Northwest and Central Switzerland approved this protocol (ID 2022–00513). Findings will be disseminated in scientific journals and meetings. Trial Registration The trial was registered on www.clinicaltrials.gov (NCT05390866, https://clinicaltrials.gov/ct2/show/NCT05390866) on May 25, 2022.
Evaluation and comparison of anxiety levels after using Guided Imagery technique for relaxation and modified Guided Imagery-Hypnotherapy technique in 6 to 14 year-old children undergoing local anesthesia administration
Authors: Parakh Himani , Thosar Nilima 
Published: August 2023

Anxiety has been defined as a “vague, unpleasant feeling accompanied by a premonition that something undesirable is about to happen”. Dental anxiety is driven by a strong negative or unpleasant emotion towards a dental office or dental procedures. Children with a high level of dental anxiety are more resistant to treatment, and due to this avoidance in dental care can lead to needing more dental treatments. The quality of a treatment being carried out, as well as what materials that are to be used, is directly influenced by a child’s level of cooperation and ability to follow instructions. Behaviour management techniques play a major role during all paediatric treatment procedures, and it is the clinician who is responsible to properly and safely guide the child’s behaviour. Guided Imagery is a visual and sensory-based complementary and alternative medicine (CAM) technique. In hypnotherapy which is a type of mind-body intervention; increased suggestibility is used in the treatment of a medical or psychological disease or condition. Therefore, there is a need of a newer modality based on guided imagery and hypnotherapy to be used in as a whole or in tandem with other conventional behaviour management techniques. The aim of this study is to evaluate and compare anxiety levels after using Guided Imagery for relaxation and modified Guided Imagery-Hypnotherapy techniques in 6-14 year-old children undergoing local anesthesia administration.
Case Report: HUGHES-STOVIN SYNDROME: A RARE ENTITY AND CHALLENGING THERAPEUTIC DECISION: CASE SERIES AND REVIEW OF THE LITERATURE
Authors: Mahjoub Lobna , Kallala Mohamed Yassine , Hammami Ahmed Sami , Saad Jamel , Kechida Melek , Dabbabi Hanen , Dada Syrine , Ben Brahim Marwa , Gamra Habib , Hassine Majed , Ouali Sonia 
Published: August 2023

Hughes-Stovin Syndrome is a systematic disorder generally revealed by deep venous thrombosis (DVT) and pulmonary artery (PA) aneurysms. Its pathogenesis is still unclear and there are no previously established diagnostic criteria or treatment guidelines. It is usually associated with Behçet disease. The aim of this study was to further enlighten this entity as it is often misdiagnosed. We report a case series of five patients with this rare pathology with a systematic literature review of all the previously reported cases.
Prevalence of Panton-Valentine leucocidin (pvl) and exfoliative toxin A (eta) gene within methicillin resistant and sensitive Staphylococcus aureus in an urban tertiary referral hospital: A molecular epidemiology pilot study
Authors: Amelia Sri , Kusumawati R. Lia , Hasibuan Mirzan , Winda Lavarina , Balatif Ridwan , Ivander Alvin 
Published: August 2023

Background: Staphylococcus aureus is well known to cause a multitude of clinical manifestations, from mild to severe bloodstream infections that could lead to death. Infections are common, either in community-acquired or hospital-acquired settings, and treatment remains a challenge due to methicillin-resistant Staphylococcus aureus (MRSA). The pathogenesis of S. aureus is mediated by several cell-surface and secreted virulence factors. The virulence factors discussed in this study are Panton-Valentine leucocidin (pvl) and exfoliative toxin A (eta). Our pilot study aimed to observe pvl and eta as virulence gene prevalence in a North Sumatera tertiary referral health center. Methods: Our study was a descriptive-analytical observational study with a cross-sectional design in which we collected isolates over a single time period. The frequency of genes is reported as a percentage comparison between MRSA and methicillin-sensitive S. aureus (MSSA). Qualitative gene prevalence analysis was carried out using the polymerase chain reaction (PCR). Results: Our results showed that from 38 MRSA sample isolates, six samples were found to be pvl-negative, or 15.7% of the total samples. From 40 MSSA sample isolates, one sample was found to be pvl-negative MSSA, or 0.025%. Regarding eta, from 38 MRSA sample isolates, 18.4% of the total sample did not have eta, while from 40 MSSA sample isolates, all samples were found to be positive for eta. We found that both pvl and eta were significantly more likely to be expressed in the MSSA strain. Conclusions: Our study shows that pvl and eta are more likely expressed in MSSA strains than in MRSA strains in Indonesia.
Programmatic mapping and estimating the population size of female sex workers, men who have sex with men, people who inject drugs and transgender populations in Kenya
Authors: Musimbi Janet , Musyoki Helgar , Mugambi Mary , Kaosa Shem , Kioko Japheth , Aluko Diane , Wanjiru Waruiru , Wambua Solomon , Prakash Ravi , Isac Shajy , Bhattacharjee Parinita , Emmanuel Faran 
Published: August 2023

Introduction: Effective coverage of Human Immunodeficiency Virus prevention services for Key Populations (KPs) including female sex workers (FSWs), men who have sex with men (MSM), people who inject drugs (PWID) and transgender (TG) people necessitates periodic validation of physical venues and size estimates. Kenya conducted a robust size estimation of KPs in 2012 and a repeat mapping and size estimation exercise was conducted in 2018 to update KP Size Estimates and sub-typologies within each County for calculation of realistic program indicators. Methods: A prospective mixed methods programmatic mapping approach adopted comprised two steps. The first step involved consolidating and documenting all known venues where KPs congregate while the second step included visiting and validating these venues confirming their active status. Data were collected in 34 out of 47 Counties in Kenya between January and March 2018. Data collected included estimated number of KPs (range), venue typology and timing of operation of each venue. Results: We estimated a total number of 167,940 (129,271 to 206,609) FSWs; 32,580 (24,704 to 40,455) MSM; 16,063 (12,426 to 19,691) PWIDs; 10,951 (8,160 to 13,742) and 4,305 (2,826 to 5,783) transgender people congregating at 10,250, 1,729, 401 and 1,218 venues respectively. Majority of the venues for FSW (81%), MSM (64%) and transgender people (67%) were bars with and without lodging, PWIDs were mostly found on streets and injecting dens (70%). Around 9% of FSW and MSM and11% of PWIDs were below the age of 18 years. Conclusion: This study provided information on young KPs, female PWIDs, MSWs and for the first time, TG people in Kenya. The exercise updated size estimates of KPs by typology and provided new evidence for resource allocation, planning of interventions and targets. Programmatic mapping continues to be a useful approach supporting programs to achieve high levels of coverage and prioritize resources.
Risk factors associated with paediatric leukemia – a preliminary study amongst parents
Authors: Kister Klaudia , Laskowski Jakub , Mazur Magdalena , Szabrańska Anna , Bronst Paulina , Czechowska Julia , Rosa Lidia , Zach-Źródlak Monika , Małolepsza Aleksandra , Rektor Natalia 
Published: August 2023

Background: Acute lymphoblastic leukemia (ALL) is the most common leukemia seen among pediatric patients. Exposure to agents such as pesticides, tobacco smoke, solvents, and air pollution associated with traffic, factories, and incinerators is consistently associated with an increased risk of developing childhood leukemia. The purpose of this article is to attempt to assess the knowledge of parents of oncology patients about possible risk factors for the development of ALL acute lymphoblastic leukemia and the need for educational campaigns to increase cancer awareness in the community.
Material and methods: For the study, the authors created a structured questionnaire that included 15 questions. The printed questionnaire was then distributed to parents staying with their children in the pediatric oncology and hematology department and the hematology-oncology outpatient clinic at 2 clinical hospitals in Poland. The survey was conducted from February to May 2023.
Results: The study group was formed by 256 people. 13% of respondents believe that breastfeeding increases a child's risk of leukemia. One in three questioned pointed to vaccinations as a possible trigger for cancer. The majority of respondents consider care facilities such as the nursery as exposure to the development of leukemia. The vast majority of respondents are dissatisfied with their knowledge of proliferative diseases.
Conclusions: The overall level of parents' knowledge of leukemia risk factors is inadequate. A large percentage of respondents indicate vaccination as a risk factor for the development of ALL There is a need for educational campaigns on childhood cancer. There is a need to verify the sources of medical knowledge used by patients, especially on the Internet.
Topical skin adhesive PRINEO as the ideal wound closure system in cardiac surgery to limit surgical site infection
Authors: Gunga Ziyad , Marchese Mario Verdugo , Pfister Raymond , Dulgorov Filip , Nowacka Anna , Rancati Valentina , Ltaief Zied , Niclaus Lars , Pretre Rene , Kirsch Matthias 
Published: August 2023

Objective: Surgical site infections (SSIs) are a major source of morbidity after cardiac surgery, involving prolonged hospitalisation. Among the numerous techniques of skin closure and dressings available, the optimal method remains undetermined. The DERMABOND-PRINEO (PRINEO) (PRINEO, Ethicon, J&J) is the only skin closure system which combines a topical skin adhesive with a mesh. Other surgical disciplines have highlighted remarkable results with PRINEO. The aim of this study was to evaluate the effects of PRINEO, used as the final layer in sternotomy closure, in the incidence of postoperative SSIs. Method: This was a retrospective single-centre cohort study including adult patients who underwent cardiac surgery between January 2015 and December 2018. Patients who had undergone heart transplantation or ventricular assist surgery were excluded. Included patients were divided into two groups depending on the type of post-operative wound care technique used. Group 1 consisted of patients who had their sternotomy closed with a standard dressing and group 2 consisted of patients who were treated with PRINEO. The primary endpoint of our study was the occurrence of SSIs and secondary outcomes were the length of hospitalisation and mortality. Results: A total of 1603 patients were reviewed with the occurrence of 44 SSIs. Both groups were homogeneous in terms of risk factors. The incidence of SSIs was significantly lower in group 2 (PRINEO) than in group 1 (standard dressing) (n=29, 3.8% vs n=15, 1.8%, respectively; p=0.042). However, there was no significant difference in the duration of hospitalisation and mortality. Conclusion: In our practice, PRINEO has proven to be a safe wound closure system after sternotomy, with a reduced SSI rate compared to conventional wound care techniques.
ANÁLISE DA CONVENÇÃO INTERNACIONAL QUE VERSA SOBRE OS DIREITOS DA PESSOA COM DEFICIÊNCIA, REFERENDADA COMO EMENDA CONSTITUCIONAL NO BRASIL, E A NOVA INTERPRETAÇÃO E CONTROLE, EM TERMOS JURÍDICOS, DO CONCEITO DE DEFICIÊNCIA PARA FINS DE DIREITO
Authors: Cláudio Souza Silva  , Carlos Eduardo Behrmann Ratis Martins  
Published: August 2023

As convenções internacionais, no âmbito do Direito, são acordos entre países que versam sobre assunto de interesse das partes envolvidas.
No Brasil, umas das mais conhecidas é a Convenção Internacional que versa sobre os Direitos das Pessoas com Deficiência: A Convenção Internacional Sobre o Direito das Pessoas com Deficiência, assinada em New York em 2007, foi acolhida pela legislação brasileira através do Decreto Legislativo n º 186, de 9 de julho de 2008. A promulgação pelo Presidente da República Luiz Inácio Lula da Silva aconteceu em 25 de agosto de 2009, através do Decreto nº 6.949, de 25 de agosto de 2009, e a partir de então a Convenção passou a ter o status de Emenda Constitucional por força do §3º art. 5º da Carta de 1988 (FILHO, 2015, p. 1).