bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, phase II selection study of ramucirumab and paclitaxel versus FOLFIRI in refractory small bowel adenocarcinoma: SWOG S1922.
Authors: Overman Michael J. , Guthrie Katherine A , Salem Mohamed E. , Pedersen Katrina Sophia , Kalyan Aparna , Colby Sarah , Fakih Marwan , Gholami Sepideh , Gold Philip Jordan , Chiorean E. Gabriela , Hochster Howard S. , Philip Philip Agop 
Published: January 2023

TPS784 Background: Small bowel adenocarcinoma is a rare malignancy with limited evidence to support the choice of systemic chemotherapy beyond the frontline setting. Though second-line therapy has historically been extrapolated from colorectal cancers, recent molecular data has demonstrated small bowel adenocarcinoma to be genomically unique when compared to either colon or gastric cancer. Retrospective analyses of irinotecan- and taxane-based therapies and one prospective phase II clinical trial of nab-paclitaxel have demonstrated clinical activity in this cancer. Ramucirumab/paclitaxel represents an active combination in the management of gastric cancer. SWOG 1922 evaluates the use of FOLFIRI or ramucirumab/paclitaxel in the second- and later-line setting for small bowel adenocarcinoma. Methods: This is randomized, phase II, selection design clinical trial of FOLFIRI (5-fluorouracil, leucovorin and irinotecan) every two weeks or ramucirumab D1,15 and paclitaxel D1,8,15 every 4 weeks with the primary endpoint of progression-free survival (PFS). Secondary endpoints include response rate, overall survival, and safety. Archived paraffin tumor tissue collection and serial blood collections are included for correlative analyses. Key eligibility criteria include having mismatch repair proficient/microsatellite stable small bowel adenocarcinoma (ampullary location excluded); metastatic or locally advanced unresectable disease; prior fluoropyrimidine and/or oxaliplatin therapy; no prior treatment with irinotecan, ramucirumab, or taxanes; no recent bleeding, blood clots, or bowel perforation/fistula; and Zubrod performance status of 0/1. Measurable disease is not required. The null hypothesis is median PFS of 2.5 months. If a median PFS of at least 3.5 months is observed in one or both arms, the goal is to choose the better regimen with respect to this endpoint. The design provides a 90% probability of selecting the more active arm, assuming a hazard ratio of 1.4, if both arms meet this threshold. This trial is open and, as of September 1, 2021, 21 of 94 planned patients have been enrolled. NCT04205968 Funding: NIH/NCI/NCTN grants U10CA180888, U10CA180819, U10CA180820, U10CA180821, U10CA180868; and in part by Eli Lilly and Company. Clinical trial information: NCT04205968 .
A prospective translational study investigating the association of gut microbiome (GM) diversity with pathological complete response (pCR) after neoadjuvant treatment in early stage rectal and esophageal cancers.
Authors: Mc Laughlin Ronan Andrew , Devoy Ciaran , moloney carolyn , Bennett Kathleen , Mcmahon David , Conroy Michael R , Fitzpatrick Orla , Egan Keith , Grogan William , Breathnach Oscar S. , Morris Patrick G. , Murphy Adrian Gerard , Naidoo Jarushka , Tangney Mark , Hennessy Bryan T. 
Published: January 2023

TPS819 Background: The gut microbiome (GM) is thought to influence host immunity by modulating multiple immunologic pathways. Studies have suggested that dysbiosis of the GM confers a predisposition to certain malignancies and influences response to immune checkpoint inhibitors. However, little is known about how the GM diversity influences complete pathological response to neoadjuvant therapy in gastrointestinal (GI) tumours. We hypothesize that a more diverse GM constitution at baseline will lead to improved pathological response at the time of definitive surgery. Methods: We designed a cross-institutional multi-center translational study investigating the impact of the GM diversity on the efficacy of neoadjuvant therapy in GI cancers by assessing its association with pathological response. The study population will consist of patients with an early-stage rectal or esophageal cancer due to commence neoadjuvant therapy (including chemotherapy and chemoradiation) and planned for definitive surgery. Patients who received prior chemotherapy/monoclonal antibodies/immune checkpoint inhibitors or radiation will be excluded. The study assessments will include fecal sampling of the GM prior to neoadjuvant therapy, upon completion and again six months post completion of therapy. Fecal samples will be analysed by 16S RNA sequencing. Pathological response will be examined at time of surgery and patients will be classified as responders (complete pathological response) or non-responders. The primary endpoint of the study is to examine the association between the GM diversity and pathological response. 120 patients will be recruited over 18 months. Results: Species richness (Alpha Diversity) will be analysed using the Shannon diversity index and Jaccard similarity index to calculate beta diversity. Classification and clustering analysis will be performed with Principal Component Analysis (PCA) and Random Forest analysis. Comparison of taxa or functions between clinical cohorts will be performed using the two tailed Z test and corrected using the false discovery rate to determine Q-values. The association between GM and complete pathological response will be examined using logistic regression analysis adjusting for potential confounding factors. Adjusted odds ratios (OR) and 95% confidence intervals will be presented. Conclusions: This study will show preliminary insights into the role of GM as a potential biomarker for neoadjuvant therapy efficacy in patients with GI cancers. Recruitment is on-going.
Late Health Outcomes Among Survivors of Wilms Tumor Diagnosed Over Three Decades: A Report From the Childhood Cancer Survivor Study
Authors: Weil Brent R. , Murphy Andrew J. , Liu Qi , Howell Rebecca M. , Smith Susan A. , Weldon Christopher B. , Mullen Elizabeth A. , Madenci Arin L. , Leisenring Wendy M. , Neglia Joseph P. , Turcotte Lucie M. , Oeffinger Kevin C. , Termuhlen Amanda M. , Mostoufi-Moab Sogol , Levine Jennifer M. , Krull Kevin R. , Yasui Yutaka , Robison Leslie L. , Armstrong Gregory T. , Chow Eric J. , Armenian Saro H. 
Published: January 2023

PURPOSE To evaluate long-term morbidity and mortality among unilateral, nonsyndromic Wilms tumor (WT) survivors according to conventional treatment regimens. METHODS Cumulative incidence of late mortality (≥ 5 years from diagnosis) and chronic health conditions (CHCs) were evaluated in WT survivors from the Childhood Cancer Survivor Study. Outcomes were evaluated by treatment, including nephrectomy combined with vincristine and actinomycin D (VA), VA + doxorubicin + abdominal radiotherapy (VAD + ART), VAD + ART + whole lung radiotherapy, or receipt of ≥ 4 chemotherapy agents. RESULTS Among 2,008 unilateral WT survivors, 142 deaths occurred (standardized mortality ratio, 2.9, 95% CI, 2.5 to 3.5; 35-year cumulative incidence of death, 7.8%, 95% CI, 6.3 to 9.2). The 35-year cumulative incidence of any grade 3-5 CHC was 34.1% (95% CI, 30.7 to 37.5; rate ratio [RR] compared with siblings 3.0, 95% CI, 2.6 to 3.5). Survivors treated with VA alone had comparable risk for all-cause late mortality relative to the general population (standardized mortality ratio, 1.0; 95% CI, 0.5 to 1.7) and modestly increased risk for grade 3-5 CHCs compared with siblings (RR, 1.5; 95% CI, 1.1 to 2.0), but remained at increased risk for intestinal obstruction (RR, 9.4; 95% CI, 3.9 to 22.2) and kidney failure (RR, 11.9; 95% CI, 4.2 to 33.6). Magnitudes of risk for grade 3-5 CHCs, including intestinal obstruction, kidney failure, premature ovarian insufficiency, and heart failure, increased by treatment group intensity. CONCLUSION With approximately 40% of patients with newly diagnosed WT currently treated with VA alone, the burden of late mortality/morbidity in future decades is projected to be lower than that for survivors from earlier eras. Nevertheless, the risk of late effects such as intestinal obstruction and kidney failure was elevated across all treatment groups, and there was a dose-dependent increase in risk for all grade 3-5 CHCs by treatment group intensity.
A Mixed-Methods Approach to Understanding the Disconnection between Perceptions of Abortion Acceptability and Support for Roe v. Wade among US Adults
Authors: Buyuker Beyza E. , LaRoche Kathryn J. , Bueno Xiana , Jozkowski Kristen N. , Crawford Brandon L. , Turner Ronna C. , Lo Wen-Juo 
Published: January 2023

Abstract
The relationship between people's attitudes about abortion acceptability and the Supreme Court decision in Roe v. Wade—two distinct but related issues—has not been rigorously explored. The authors used a mixed-methods approach for analyzing in-depth interviews to better understand how participants' feelings toward abortion acceptability are related to perceptions of whether abortion should be legal. The authors then assessed (1) correlations between abortion acceptability and different measures of support for Roe v. Wade, and (2) how the phrasing of survey items related to Roe v. Wade may evoke different responses via an online survey fielded in 2018. The study's qualitative results highlight that there is a disjuncture between people's moral feelings toward abortion and their attitudes toward abortion legality. The study's quantitative results further demonstrate that correlations between abortion acceptability and support for Roe v. Wade are moderate, and the differences in responses to the phrasing of survey items related to Roe v. Wade are moderated by knowledge. The authors recommend that when researchers develop survey items, they avoid ambiguities of abortion as a general construct, especially when public opinion measures on abortion are employed for research and the design of social and health policy and practice.
The effects of lateral meniscus posterior root tears or repair with anterior cruciate ligament reconstruction on the pressure of the patellofemoral joint: A biomechanical evaluation
Authors: Zhang Qian , Dong Jiangtao , Zheng Xiaozuo , Kang Kai , Gao Shijun 
Published: January 2023

Objective: The aim of our study was to evaluate the effect of tear and repair of the lateral meniscal posterior root (LMPR) on the patellofemoral contact pressure of the knee after anterior cruciate ligament (ACL) reconstructed.
Methods: This was a descriptive study. Six fresh-frozen cadaveric knees collected by The Third Hospital of Hebei Medical University from January 2019 and January 2022 were placed on a customized testing rig. Patellofemoral contact pressures were measured at 30°, 60°, and 90° of flexion using pressure-sensitive film inserted between the patella and trochlea. The following knee states were tested: ACL reconstruction and intact lateral meniscus, ACL reconstruction, and LMPR tear, and ACL reconstruction and LMPR repair. Pressure measurements were recorded for each state.
Results: In the ACL-reconstructed knee, a tear of the LMPR increased patellofemoral contact pressure at 30° of knee flexion. The repair of the posterior root by transosseous pull-out suture reduced the patellofemoral contact pressure as the status of intact lateral meniscal posterior root at 30° of knee flexion. There was no statistical difference between ACL reconstruction with the intact meniscal root and with the meniscal root tear and with the meniscal root repair at 60° and 90° of knee flexion.
Conclusion: The posterior root tear and repair of the lateral meniscus could have an influence on patellofemoral contact stress of the knee after ACL reconstruction at 30° of knee flexion.
doi: https://doi.org/10.12669/pjms.39.2.6692
How to cite this: Zhang Q, Dong J, Zheng X, Kang K, Gao S. The effecting of lateral meniscus posterior root tears or repair with anterior cruciate ligament reconstruction on the pressure of the patellofemoral joint: A biomechanical evaluation. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6692
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Risk factors associated with prolonged intensive care unit stay in post coronary artery bypass grafting patients with chronic kidney disease
Authors: Syeda Huma Zartash , Saleem Sidra , Rasool Zain , Mansur Abeera 
Published: January 2023

Objective: Prolonged intensive care unit stay not only increases hospital cost but it also prevents hospital equipment to be used by other patients who need them. The aim of this study was to identify factors that affect the duration of intensive care unit stay in post coronary artery bypass grafting patients with chronic kidney disease.
Method: This is a single centered observational prospective study done on 191 post coronary artery bypass grafting patients from June 2018 to April 2019 at Cardiac Surgery Unit of Doctor’s hospital and medical center, Lahore, Pakistan. Patients above 18 years with and without chronic kidney disease were included.
Results: Mean age of the patients was 57.83 years (± 9.862 SD. Logistic regression analysis shows that patients with post op arrhythmias had the strongest positive association with prolonged intensive care unit stay (OR:11; p value :<0.01), followed by recent myocardial infarction less than 90 days pre coronary artery bypass grafting (OR:5.93; p value:<0.01), shock (OR:3.93;p value:0.04) and acute kidney injury (OR :2.08;p value:0.04). 37.5% chronic kidney disease patients with recent myocardial infarction less than 90 days pre coronary artery bypass grafting and 51.4% patients of chronic kidney disease found with acute kidney injury, showed significant association with p values less than 0.05.
Conclusion: Post op arrhythmias, recent myocardial infarction, shock and acute kidney injury are independent risk factors causing prolonged intensive care unit stay in post coronary artery bypass grafting patients.
doi: https://doi.org/10.12669/pjms.39.2.6735
How to cite this: Zartash SH, Saleem S, Rasool Z, Mansur A. Risk factors associated with prolonged intensive care unit stay in post coronary artery bypass grafting patients with chronic kidney disease. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6735
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
An exploration of prenatal breastfeeding self-efficacy: a scoping review protocol
Authors: McGovern Liz , Geraghty Aisling , McAuliffe Fionnuala , O'Reilly Sharleen 
Published: January 2023

Objective: To synthesise the evidence on prenatal breastfeeding self-efficacy, including identifying concepts and theoretical frameworks that underpin its development, the evidence on its measurement, interventions used to improve it, and association with breastfeeding outcomes. Background: Breastfeeding self-efficacy is described as a woman’s self-belief and confidence in her perceived ability to breastfeed. It is a modifiable measure that is strongly associated with breastfeeding outcomes such as initiation, exclusivity, and duration. Interventions aimed at increasing self-efficacy are often in the postnatal period and have been shown to be effective at improving breastfeeding outcomes. The prenatal period appears to be underexplored in the literature and yet focusing on enhancing it may have the potential for further improvements in self-efficacy and on subsequent breastfeeding outcomes. A comprehensive knowledge synthesis on prenatal breastfeeding self-efficacy is lacking. Methods: The search will include databases across health, psychology, sociology, and the grey literature on breastfeeding guidance. Once the PCC framework (Problem: breastfeeding, Concept: self-efficacy, Context: prenatal period) is met, sources of evidence from any contextual setting will be eligible for inclusion. Limits will not be applied on geographic location or year of publication. The PRISMA-ScR flow diagram of search and study selection will be used to report final figures. Two independent reviewers will perform title and abstract screening and full text review. Data will be charted to provide a logical and descriptive summary of the results that align with the objectives. Conclusion: The results will provide an understanding of what has been done in the space and what gaps exist, informing recommendations for the timing of measurement and the design of prenatal interventions.
Caregiving burdens of family members of patients living with hepatocellular carcinoma
Authors: Hua Lu-Shu , Chen Ya-Yun , Yiin Jia-Jean , Lee Kwo-Chen 
Published: January 2023

Background: Caregiving burden is common among family caregivers (FCs). In Taiwan, no reports have compared caregiving burden according to disease stage, or explored the comprehensive factors of caregiving burden in the FCs of patients with hepatocellular carcinoma (HCC). Aim: The aim of the study was to investigate caregiving burden at different diagnosis stages and its potential predictors in the FCs of patients with hepatocellular carcinoma. Methods: This descriptive, cross-sectional study included 192 FCs. Caregiving burden was measured using the Caregiver Reaction Assessment tool. The predictive factors of caregiving burden in the FCs of patients with HCC were identified using a linear regression model. Results: The global caregiving burden had no significant differences between the four disease stages. The lack of family support and impact on schedule were significantly higher at the terminal stage than at the earlier stage. The risk factors of caregiving burden were high depression, high financial demand, heavy caregiving tasks, advanced age and frequent patient contact, which obtained a variance of 47.8% in the regression model. Conclusion: Healthcare providers need to proactively identify and assess FCs with risk factors of caregiving burden and provide appropriate interventions specific to individual needs at different disease stages.
Fear of COVID-19 and its influence on palliative care patients
Authors: Kocatepe Vildan , Yildirim Dilek , Yağmur Sümeyya 
Published: January 2023

Background: Fear of COVID-19 may have adverse psychological effects on palliative patients; it may also reduce their quality of life, increase physical symptoms and lead to the postponement of treatment. Aim: This study aimed to determine how the fear of COVID-19 influences factors (personal and disease-related characteristics) in palliative care patients. Methods: A descriptive, cross-sectional design study was conducted on 110 patients. A patient information form, the ‘Fear of COVID-19 scale’ and the Eastern Cooperative Oncology Group performance status were used for data collection. Findings: The mean score obtained from the COVID-19 scale was 20.44±5.78. There was a statistical significance between the stage of disease and the fear of COVID-19 score. The fear of COVID-19 was higher for participants who had received polymerase chain reaction testing. Conclusion: There was a positive and statistically significant relationship between the oxygen flow rate and fear of COVID-19 score, as well as a statistically significant relationship between the stage of disease and fear of COVID-19 score. It was determined that the COVID-19 pandemic process affected the mental health of palliative care patients.
The FR BCPPm: A novel, hybrid function regulator
Authors: Chate Rob AC 
Published: January 2023

The design features of a novel, hybrid function regulator, the FR BCPPm, are presented to facilitate the construction of other such appliances that may be used in the treatment of juveniles with a prominent premaxilla associated with a bilateral cleft lip and palate and mandibular retrusion. As an essential prerequisite to facilitate secondary alveolar bone grafting, how it may be used and the results that can be achieved are documented in a single case. CPD/Clinical Relevance: To illustrate the design features of a novel function regulator in detail, which may be used to correct a prominent premaxilla in a patient with bilateral cleft lip and palate.
A comparison of preoperative scores prior to anterior cruciate ligament reconstruction with optimal preinjury scores and final scores at two-year follow up
Authors: Gabr Ayman , Haddad Fares S. 
Published: January 2023

Aims The aim of this study was to compare the preinjury functional scores with the postinjury preoperative score and postoperative outcome scores following anterior cruciate ligament (ACL) reconstruction surgery (ACLR). Methods We performed a prospective study on patients who underwent primary ACLR by a single surgeon at a single centre between October 2010 and January 2018. Preoperative preinjury scores were collected at time of first assessment after the index injury. Preoperative (pre- and post-injury), one-year, and two-year postoperative functional outcomes were assessed by using the Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm Knee Score, and Tegner Activity Scale. Results We enrolled 308 males and 263 females of mean age 27 years (19 to 46). The mean preinjury and preoperative post-injury Lysholm Knee Scores were 94 (73 to 100) and 63 (25 to 85), respectively, while the respective mean scores at one and two years postoperatively were 84 (71 to 100) and 89 (71 to 100; p < 0.001). The mean Tegner preinjury and preoperative post-injury scores were 7 (3 to 9) and 3 (0 to 6), respectively, while the respective mean scores at one and two years postoperatively were 6 (1 to 8) and 6 (1 to 9) (p < 0.001). The mean KOOS scores at preinjury versus two years postoperatively were: symptoms (96 vs 84); pain (94 vs 87); activities of daily living (97 vs 91), sports and recreation function (84 vs 71), and quality of life (82 vs 69), respectively (p < 0.001). Conclusion Functional scores improved following ACLR surgery at two years in comparison to preoperative post-injury scores. However, at two-year follow-up, the majority of patients failed to achieve their preinjury scores. The evaluation of ACLR outcomes needs to consider the preinjury scores rather than the immediate preoperative score that is usually collected. Cite this article: Bone Jt Open 2023;4(1):46–52.
Vale do Pati (Mirante)
Authors: Puiggrós Lucía Elena 
Published: January 2023

- A natureza é imensa, ao lado dela, somos ínfimos, mas ao mesmo tempo, somos parte dela, e ela e parte de nós. -Esse projeto procura mostrar, de um jeito poético, natural, e crú a integração desses corpos com a grandiosa natureza da Chapada Diamantina. A traves de uma linguajem única, criada no momento, em função das formas que vou achando, tanto dos corpos humanos, como dos elementos da natureza: pedra, terra, agua, arvores. O resultado: Beleza, equilíbrio, harmonia e união.
Fragmentos de Partes Musicais da Philarmônica Lyra Popular
Authors: Popular Lyra 
Published: January 2023

O Primeiro Livro de Partes Musicais Digitalizadas da Phylarmônica Lyra Popular de Lençóis é um esforço de parceria entre a Lyra e a Universidade Estadual de Feira de Santana (UEFS), do seu Campus Avançado da Chapada Diamantina (CACD) e pretende marcar o início do ano de comemoração dos 120 anos da Lyra, com o compromisso da UEFS-CACD de disponibilizar o acervo da Lira, ao mundo.
Essa é uma viagem histórica e musical, emocionante e informativa, que apresenta parte do acervo musical da Sociedade Phylarmônica Lyra Popular de Lençóis-Bahia. Um desafio, aqui ainda inicial e pequeno, que manterá resguardadas 150 partes musicais, as primeiras digitalizadas pela UEFS em Feira de Santana, vamos em frente. Esta é uma ínfima parte do grande acervo musical da Sociedade, que não só resiste secularmente, mas também a ausência de políticas públicas estáveis e contínuas para preservação da memória e da cultura, especialmente fora dos grandes centros urbanos. .