bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong evidence for positive and negative correlational selection revealed by recreating ancestral variation
Authors: Waterman Robin , Sahli Heather , Koelling Vanessa A , Karoly Keith , Conner Jeffrey K 
Published: January 2023

Abstract
The study of adaptation helps explain biodiversity and predict future evolution. Yet the process of adaptation can be difficult to observe due to limited phenotypic variation in contemporary populations. Furthermore, the scarcity of male fitness estimates has made it difficult to both understand adaptation and evaluate sexual conflict hypotheses. We addressed both issues in our study of two anther position traits in wild radish (Raphanus raphanistrum): anther exsertion (long filament − corolla tube lengths) and anther separation (long − short filament lengths). These traits affect pollination efficiency and are particularly interesting due to the unusually high correlations among their component traits. We measured selection through male and female fitness on wild radish plants from populations artificially selected to recreate ancestral variation in each anther trait. We found little evidence for conflicts between male and female function. We found strong evidence for stabilizing selection on anther exsertion and disruptive selection on anther separation, indicating positive and negative correlational selection on the component traits. Intermediate levels of exsertion are likely an adaptation to best contact small bees. The function of anther separation is less clear, but future studies might investigate pollen placement on pollinators and compare species possessing multiple stamen types.
Sustainable development in general practice
Authors: Legrand Julie , Aubin-Auger Isabelle , De Bary Louise , Fossembas Élodie , Baruch Dan , Malmartel Alexandre 
Published: January 2023

Abstract

Background
As health care accounts for 4–5% of global carbon emissions, many health organisations have called for implementing sustainable development actions in health care. However, sustainable development measures in general practice are rarely implemented by physicians. The aim of this study was to explore the practices of general practitioners (GPs) in terms of sustainable development to identify which actions are appropriate and achievable.

Methods
A qualitative study was conducted in 12 French GPs using face-to-face or telephone interviews, transcribed verbatim and analysed through a global inductive analysis with constant comparison. Semi-structured interviews were focussed on waste management, relationships between health professionals, sustainable development, and GPs’ activity.

Results
The mean age of the GPs was 42.8 years and they mainly worked in an urban environment. The interviews highlighted 4 themes. It appeared that a balance needs to be found between the environmental impact and the constraints related to medical care. To be able to think about integrating sustainable development into health care, GPs should make a personal commitment to change their routine. In practice, consumption should be reassessed, prescriptions and prevention reconsidered. These actions could be applied to the GPs’ environment as role models for their patients, business leaders, and members of the healthcare system.

Conclusion
GPs felt concerned by sustainable development and were already involved in its implementation in their practice. Tools are available to help GPs to continue to implement their actions described in this article, but their impact remains to be investigated.
Contemporary Values Encounter Classic Illustrations in Rebecca Solnit’s Cinderella Liberator (2019)
Authors: Oancea Ana 
Published: January 2023

Abstract
Rebecca Solnit’s retelling of ‘Cinderella’ in Cinderella Liberator (2019) transforms the fairy tale by infusing a slew of modern ideas into its ‘once upon a time’. Cinderella becomes an independent, active, empowered heroine not only freed from servitude, but able to liberate others in her community from oppression. While the rewriting targets the morals and values of traditional ‘Cinderella’ texts, it is anchored in a specific version of the tale. Cinderella Liberator reuses illustrations Arthur Rackham produced for a 1919 Cinderella gift book by C. S. Evans. This article analyses the interplay of text and image in Cinderella Liberator to establish how the particularities of the Evans/Rackham version inflect the adaptation’s wider discourse on the Cinderella narrative. It focuses on images correlated with the fairy tale’s reassessment of the value and significance of work, the separation of social classes and of external appearance as an indication of moral values.
Polymorphic justice and the crisis of international order
Authors: Reus-Smit Christian , Zarakol Ayşe 
Published: January 2023

Abstract
The post-1945 international order is in crisis, spurring a wide-ranging debate about its future in a period of rapid global change. A critical dimension of this crisis has been neglected by existing perspectives, however. At multiple levels the post-1945 international order is being challenged by claims of justice. Diverse actors criticize the order for its economic inequalities, social hierarchies, institutional unfairness, intergenerational inequities, and historical and epistemic injustices. This article, which serves as an introduction to a special section on ‘Injustice and the crisis of international order’ seeks to map and explicate this polymorphic politics of global justice. We begin by reviewing past debates about justice and order in world politics, highlighting their narrow and over-stylized engagement with justice politics. To fill this gap, we develop a typology of contemporary justice claims, differentiating between recognitional, institutional, distributive, historical and epistemic, and intergenerational claims. Our goal is not only to distinguish these distinct kinds of justice claims, however. We argue that justice claims are also intersectional, multiscalar and multivocal, with significant implications for how the relationship between justice and order is managed in contemporary world politics.
Hegemonic world orders, distributional (in)justice and global social change
Authors: Karataşlı Şahan Savaş 
Published: January 2023

Abstract
Focusing on the relationship between distributional justice and hegemonic world orders, this article turns attention to a fundamental contradiction in historical capitalism between profitability and legitimacy that manifests itself in successive creative destructions of hegemonic orders. Through a comparative–historical analysis of world hegemonies, I show that increasing distributional injustices during periods of ‘legitimacy crisis’ compel new hegemonic powers to pragmatically address some of these injustices as a part of their hegemony-building strategies. Despite growing efforts by world hegemonic powers to address such distributional injustices, social and global inequalities in the capitalist world-economy tend to increase over time. As social and global inequalities increase, new hegemonic powers are compelled to make greater promises and to undertake much greater efforts to address distributional injustices in order to gain intellectual and moral leadership in an emergent new world order. Yet, none of these efforts become successful in the long run because even the partial successes of redistribution policies pave the way for ‘profitability crises’ and undermined world hegemonies. This dynamic poses several challenges to achieving global distributional justice in an emergent new capitalist world order.
Temperature analysis of aortic repair with hypothermic circulatory arrest to quantify the injury by cooling
Authors: Sato Hiroshi , Iba Yutaka , Kawaharada Nobuyoshi , Fukada Joji , Iwashiro Yuu , Tsushima Shingo , Hosaka Itaru , Okawa Akihito , Shibata Tsuyoshi , Nakazawa Jyunji , Nakajima Tomohiro , Hasegawa Takeo , Tamiya Yukihiko 
Published: January 2023

AbstractOBJECTIVESWe analyzed the temperature in proximal aortic repair with moderate hypothermic circulatory arrest (HCA) and evaluated the effect of the cooling status on postoperative outcomes.METHODSA total of 340 patients who underwent elective ascending aortic replacement or total arch replacement with moderate HCA from December 2006 to January 2021 were studied. The change in body temperature trends recorded during surgery was shown graphically. Several parameters, such as the nadir temperature, cooling speed and the degree of cooling (cooling area), which was the area under curve of inverted temperature trends from cooling to rewarming as calculated by the integral method, were analyzed. The relationships between these variables and a major adverse outcome (MAO) postoperatively defined as prolonged ventilation (&gt;72 h), acute renal failure, stroke, reoperation for bleeding, deep sternal wound infection or in-hospital death were evaluated.RESULTSAn MAO was observed in 68 patients (20%). The cooling area was larger in the MAO group than in the non-MAO group (1668.7 vs 1383.2°C min; P &lt; 0.0001). A multivariate logistic model showed that old myocardial infarction, peripheral vascular disease, chronic renal dysfunction, cardiopulmonary bypass time and the cooling area were independent risk factors for an MAO (odds ratio = 1.1 per 100°C min; P &lt; 0.001).CONCLUSIONSThe cooling area, which indicates the degree of cooling, shows a significant relationship with an MAO after aortic repair. This finding indicates that the cooling status with HCA can affect clinical outcomes.
Intraosseous hibernoma in the rib
Authors: Song Minglei , Liu Hui , Zhang Lingling , Gao Liping 
Published: January 2023

AbstractA 64-year-old man was admitted with paroxysmal left-side thoracic pain. CT scan showed an irregular appearance, expansile, osteolytic lesion of the left seventh rib. Wide en bloc excision of the tumour was performed. Macroscopic examination showed that a 3.5 cm × 3.0 cm × 3.0 cm solid lesion with destruction of bone. Histological examination showed that the tumour cells were arranged in plate shaped and interspersed between the bone trabeculae. Mature adipocytes were noted in the tumour tissues. The immunohistochemical stainings showed that the vacuolated cells were positive for S-100 protein and negative for CD68 and CD34. These clinicopathological features were consistent with intraosseous hibernoma.
How Social Media Influencers Impact Consumer Collectives: An Embeddedness Perspective
Authors: Mardon Rebecca , Cocker Hayley , Daunt Kate 
Published: January 2023

Abstract
Research has documented the emergence of embedded entrepreneurs within consumer collectives. This phenomenon is increasingly prevalent as social media enables ordinary consumers to become social media influencers (SMIs), a distinct form of embedded entrepreneur. Whilst research has considered the implications of embeddedness for embedded entrepreneurs themselves, we lack insight into embedded entrepreneurship’s impact on consumer collectives. To address this gap, we draw from a longitudinal, qualitative study of the YouTube beauty community, where SMIs are pervasive. Informed by interactionist role theory, we document the Polanyian “double movement” prompted by the emergence of SMIs within the community. We demonstrate that the economy within the community was initially highly embedded, constrained by behavioral norms linked to established social roles. SMIs’ attempts to disembed the economy created dysfunctional role dynamics that reduced the benefits of participation for non-entrepreneurial community members. This prompted a countermovement whereby SMIs and their followers attempted to re-embed SMIs’ economic activity via role negotiation strategies. Our analysis sheds new light on the negative implications of embedded entrepreneurship for non-entrepreneurial members of consumer collectives, highlights the role of social media platforms in negotiations of embeddedness, and advances wider conversations surrounding the evolution of consumer collectives and the impact of SMIs.
Supporting the Transition to Climate-Neutral Production: An Evaluation Under the Agreement on Subsidies and Countervailing Measures
Authors: Ismer Roland , van Asselt Harro , Haverkamp Jennifer , Mehling Michael , Neuhoff Karsten , Pirlot Alice 
Published: January 2023

ABSTRACT
To reach climate neutrality, carbon emissions from the production of basic materials need to be curtailed. When governments encourage this transition by adopting support measures, the measures must comply with the Agreement on Subsidies and Countervailing Measures. This article analyzes three selected support schemes under the Agreement on Subsidies and Countervailing Measures: (i) free allocation under emissions trading systems to operators of installations at risk of carbon leakage; (ii) the combination of a charge on carbon-intensive materials with free allocation; and (iii) carbon contracts for difference, under which governments cover the incremental costs of climate-neutral production processes relative to conventional processes. The analysis reveals that the current regime of free allocation is vulnerable to challenges under the Agreement on Subsidies and Countervailing Measures. By contrast, the combination of free allocation and a charge on carbon-intensive materials would ensure consistent carbon pricing and thus would not amount to a subsidy under the Agreement on Subsidies and Countervailing Measures. In a similar vein, the carbon contracts for difference could be designed so that they would not confer a benefit and hence not constitute a subsidy.
Modifiers of radiation effects on breast cancer incidence revealed by a reanalysis of archival data of rat experiments
Authors: Imaoka Tatsuhiko , Nishimura Mayumi , Daino Kazuhiro , Kakinuma Shizuko 
Published: January 2023

AbstractCancer risk after exposure to ionizing radiation can vary between individuals and populations, but the impact of factors governing those variations is not well understood. We previously conducted a series of carcinogenesis experiments using a rat model of breast cancer, in which 1654 rats born in 2002–2012 were exposed to γ rays at various doses and ages with or without non-radiation factors including high-fat diet, parity and chemical carcinogens. We herein reanalyze the incidence data from these archival experiments to clarify the effect of age at exposure, attained age, radiation dose and non-radiation factors (i.e. fat, parity, chemicals and birth cohorts) on radiation-related mammary cancer incidence. The analysis used excess relative risk (ERR) and excess absolute risk (EAR) models as well as generalized interaction models. Age-at-exposure dependence displayed a peak of susceptibility at puberty in both the ERR and EAR models. Attained age decreased ERR and increased EAR per unit radiation dose. The dose response was concordant with a linear model. Dietary fat exhibited a supra-multiplicative interaction, chemicals represented a multiplicative interaction, and parity and birth cohorts displayed interactions that did not significantly depart from additivity or multiplicativity. Treated as one entity, the four non-radiation factors gave a multiplicative interaction, but separation of the four factors significantly improved the fit of the model. Thus, the present study supports age and dose dependence observed in epidemiology, indicates heterogenous interactions between radiation and various non-radiation factors, and suggests the potential use of more flexible interaction modeling in radiological protection.
Analysis of the relationship between LET, γH2AX foci volume and cell killing effect of carbon ions using high-resolution imaging technology
Authors: Oike Takahiro , Kakoti Sangeeta , Sakai Makoto , Matsumura Akihiko , Ohno Tatsuya , Shibata Atsushi 
Published: January 2023

AbstractThe strong cell killing effect of high linear energy transfer (LET) carbon ions is dependent on lethal DNA damage. Our recent studies suggest that induction of clusters of double-strand breaks (DSBs) in close proximity is one of the potential mechanisms. However, the relationship between LET, the degree of DSB clustering and the cell killing effect of carbon ions remains unclear. Here, we used high-resolution imaging technology to analyze the volume of γH2AX foci induced by monoenergetic carbon ions with a clinically-relevant range of LET (13–100 keV/μm). We obtained data from 3317 γH2AX foci and used a gaussian function to approximate the probability (p) that 1 Gy-carbon ions induce γH2AX foci of a given volume (vth) or greater per nucleus. Cell killing effects were assessed in clonogenic assays. The cell killing effect showed high concordance with p at vth = 0.7 μm3 across various LET values; the difference between the two was 4.7% ± 2.2%. This relationship was also true for clinical carbon ion beams harboring a mixed LET profile throughout a spread-out Bragg peak width (30–120 mm), with the difference at vth = 0.7 μm3 being 1.6% ± 1.2% when a Monte Carlo simulation-derived dose-averaged LET was used to calculate p. These data indicate that the cell killing effect of carbon ions is predictable by the ability of carbon ions to induce γH2AX foci containing clustered DSBs, which is linked to LET, providing the biological basis for LET modulation in the planning of carbon ion radiotherapy.
Psychographic profiling — a method for developing relatable avatars for a direct-to-consumer mobile game for adolescent girls on mobile in India
Authors: Raj Aparna , Quilter Isabel , Ashby Elizabeth , Dixit Anvita , Howard Susan 
Published: January 2023

Abstract
This research aimed to conduct psychographic profiling for developing a direct-to-consumer mobile game targeting the sexual and reproductive health of adolescent girls in India. We used semi-structured tools to collect information on role models, family, education, dreams, fears and decision-making power. We also presented visual stimuli to the participants (Indian girls; age: 15–19 years; N = 103). Responding to the stimuli, the participants expressed their perceptions of social norms, moral standards, obligations and aspirations. We carried out thematic analysis using predetermined codes and did an inductive analysis to identify emergent profiles. Analysis revealed seven primary themes that influence the participants’ aspirations, decisions and agency: (i) clarity regarding career goals, (ii) information about the pathways to reach those goals, (iii) efforts toward achieving goals, (iv) clarity about priorities, (v) parental support, (vi) ability and willingness to negotiate and (vii) social mobility. Based on combinations of these themes, four predominant personas emerged as descriptive categories of girls’ lives and attitudes. These four profiles will form the basis of Game of Choice, Not Chance™ game: informing the scenarios, in-game decisions and relatable content. This study represents a novel approach to research for an equally innovative game for agency building and health awareness among adolescents.
Barn Swallows in East Asia show strong tolerance against nest mites
Authors: Liu Yu , Tian Li , Zhou Zhuoya , Gao Kai , Chen De , Li Donglai , Wang Yong , Zhang Zhengwang 
Published: January 2023

AbstractHosts defend against parasites through two main strategies: resistance and tolerance. These two strategies have different influences on the parasite load of the host and so have variable effects on the fitness of parasites. In this study, we investigated the strategy used by the Barn Swallow (Hirundo rustica) to defend against a hematophagous mite (Dermanyssus hirundinis) in East Asia. For the first time, we found Barn Swallows were parasitized by D. hirundinis in Asia and, in northeastern China, over 60% of broods were parasitized. We examined whether swallows with better body condition or the males with more extravagant sexually selected traits (longer tail streamers or redder ventral plumage) showed stronger resistance or tolerance to these parasites. The results showed that males with more extravagant sexual ornaments had weaker resistance (heavier brood mite load) than males with less extravagant traits; however, the heavier mite load was likely to be a byproduct of larger brood size. Moreover, the Barn Swallow population showed strong tolerance against the parasite (i.e. the brood mite load did not affect brood size or nestling body mass). It is worth noting that male swallows with redder breast plumage showed weaker tolerance (lower seasonal reproductive success) than other males. Further, we conducted experimental ectoparasite manipulations in 46 Barn Swallow nests to verify the potential effect of these parasites on the body condition of nestlings. Neither the body mass nor the hemoglobin concentration differed between the designed groups; however, the hemoglobin concentration of nestlings decreased with mite load. We concluded that the Barn Swallow population in East Asia used the tolerance strategy, rather than resistance to defend against nest mites, and the ectoparasitic mite did not appear to be a strong selective factor for reproductive success owing to the strong tolerance of the studied Barn Swallow population.
A new solution for the deformations of an initially elliptical elastic-walled tube
Authors: Netherwood D J , Whittaker R J 
Published: January 2023

SummaryWe investigate the small-amplitude deformations of a long thin-walled elastic tube having an initially axially uniform elliptical cross-section. The tube is deformed by a (possibly non-uniform) transmural pressure. At leading order, its deformations are shown to be governed by a single partial differential equation (PDE) for the azimuthal displacement as a function of the axial and azimuthal co-ordinates and time. Previous authors have obtained solutions to this PDE by making ad hoc approximations based on truncating an approximate Fourier representation. In this article, we instead write the azimuthal displacement as a sum over the azimuthal eigenfunctions of a generalised eigenvalue problem and show that we are able to derive an uncoupled system of linear PDEs with constant coefficients for the amplitude of the azimuthal modes as a function of the axial co-ordinate and time. This results in a formal solution of the whole system being found as a sum over the azimuthal modes. We show that the $n$th mode’s contribution to the tube’s relative area change is governed by a simplified second-order PDE and examine the case in which the tube’s deformations are driven by a uniform transmural pressure. The relative errors induced by truncating the series solution after the first and second terms are then evaluated as a function of both the ellipticity and pre-stress of the tube. After comparing our results with Whittaker et al. (A rational derivation of a tube law from shell theory, Q. J. Mech. Appl. Math. 63 (2010) 465–496), we find that this new method leads to a significant simplification when calculating contributions from the higher-order azimuthal modes, which in turn makes a more accurate solution easier to obtain.