bluuebunny/crossref_metadata_2025_split huggingface dataset:
0695 The Association Between Social Support at Work and Sleep Quality
Authors: Shurovi Sumayya , David Michelle , Sedano Brandon Fernandez , Cornelius Talea , Schwartz Joseph , Abdalla Marwah 
Published: May 2023

Abstract

Introduction
Social support, including support received by coworkers, is associated with one’s emotional well-being. Poor sleep quality among employees is associated with worse employee health, increased workplace injury and is a growing occupational health problem. Social support at home is known to positively impact sleep quality. However, whether social support at work affects sleep quality is unknown. We examined whether social support at work is associated with sleep quality.

Methods
The Worksite Blood Pressure study is a multi-site study of psychological factors and ambulatory blood pressure. The study recruited 472 participants without major cardiovascular disease from 10 New York City worksites during 4 waves over 11 years. The current analysis was restricted to 189 employed participants at Wave 4 and provided complete data. Participants completed the Job Content Questionnaire which assessed psychosocial and social characteristics of jobs, including social support received from coworkers and supervisors, and a sleep questionnaire. The sleep questionnaire assessed sleep quality, self-reported sleep duration, alertness, and sleep habits. For this analysis, items related to sleep quality were summed. Higher scores indicated worse sleep quality. A linear regression model was specified predicting sleep quality from social support at work. Study site, age, race/ethnicity, marital status, total number of people at home, and years of education were included as covariates.

Results
Of the 189 participants, 72.5% were male, 16.4% were Black, 7.4% were Hispanic/Latinx, and 73.0% were married. Mean age was 50.1 years (SD = 7.0), mean years of education was 17.8 (SD = 3.2), and median number of people at home was 3 (Range 0, 6). Mean support at work was 23.3 (SD = 3.9) and mean sleep quality was 8.6 (SD = 4.4). Social support at work was not significantly associated with sleep quality, B = 0.12, 95% CI -0.29, 0.05, p = 0.16. Sensitivity analyses that examined support from supervisors and from coworkers separately were also not significant, p &gt; 0.20.

Conclusion
Social support at work was not significantly associated with sleep quality in our cohort. Factors beyond social support at work should be investigated to evaluate their associations with employees’ sleep quality.

Support (if any)
P01HL47540
0696 The Moderating Role of Sleepiness among Intraday Passive and Active Suicidal Ideation
Authors: Bishop Todd , Porter Andrew 
Published: May 2023

Abstract

Introduction
Disrupted sleep has been linked to suicidal thought and behavior. Less is known regarding underlying mechanisms of this relationship. A more nuanced understanding of the link between sleep and suicide may help inform treatment decisions and the development of prevention and intervention strategies. We examine prior day sleepiness as a moderator to the relationship between passive and active suicidal ideation (SI).

Methods
Young adults (mean age=21.04; SD=2.22) endorsing SI (n=59) at least twice in the past two weeks were enrolled in a trial examining potential iatrogenic effects of the ecological momentary assessment (EMA) of SI. A baseline battery collected data on past suicidal thought and behavior, demographics, and psychological distress. EMA surveys were administered randomly five times per day over four weeks and assessed sleepiness and current emotional state including occurrence and severity of SI and passive/active ideation.

Results
Altogether, 835 daily average EMA entries were utilized in the present analysis. A significant relationship (p&lt;.05) was observed between sleepiness and passive SI and its impact on the intensity and duration of SI. Specifically, the association between passive and active SI was stronger on days that participants endorsed greater sleepiness. There was also a significant interaction such that one’s desire to die and a low desire to stay awake significantly interacted (p&lt;.05) to predict same-day perceived controllability of SI. Meaning that when participants had a lower desire to stay awake, there was a stronger relationship among perceived ability to control one’s SI and lower desire to live.

Conclusion
This study examined the impact of daily sleepiness on relationships among passive and active SI among young adults endorsing suicidal thought. Findings indicate that the relation between daily passive and active SI severity grows stronger the sleepier one is relative to their average level of sleepiness. Future studies should incorporate objective measures of sleep to further explore these findings and clinical implications.

Support (if any)
This study was funded by the American Psychological Foundation. This work was also supported, in part, by the VA Center of Excellence for Suicide Prevention. Authors’ views do not necessarily represent those of the Department of Veterans Affairs or the United States Government.
0699 Longitudinal Assessment of Buprenorphine Effectiveness for Severe Restless Legs Syndrome and Dopaminergic Augmentation
Authors: Berkowski Joseph Andrew , Wang Lu , Mehra Reena 
Published: May 2023

Abstract

Introduction
Opioids are a consensus second-line treatment for moderate-to-severe restless legs syndrome (RLS). Due to its partial mu-opioid receptor agonist mechanism, buprenorphine (bup) has lower risk of respiratory depression, euphoria, and dependence than full-agonist opioids. We hypothesize that with long-term administration for severe RLS, bup is both effective and well-tolerated and can facilitate successful weaning off dopamine agonists (DA) for patients with augmentation.

Methods
We conducted a longitudinal examination of a retrospective cohort of patients prescribed bup over a 21-month period by a tertiary RLS specialist. Patient-reported outcomes were administered through patient-completed electronic health record-based questionnaires or by clinician interview: International RLS Study Group(IRLS-SG,primary outcome), Clinical Global Impressions of Improvement(CGI-I), Epworth Sleepiness Scale(ESS), Insomnia Severity Index(ISI), Patient Health Questionnaire(PHQ-9), and Patient-Reported Outcomes Measurement Information System-Sleep Disturbance domain(PROMIS-SD). A linear mixed model assuming compound symmetry correlation structure was used (least square means,95%CI) to test the change from baseline to 6-week, 3-month, 6-month, and 1-year intervals, and the final visit, irrespective of time from baseline, with adjustment of age, sex, other RLS meds at final visit, and administration of iron infusion.

Results
55 patients (56.4% female, 64.9±12.1 years) started bup for RLS, and 42(76.3%) remained on bup at the final visit. IRLS-SG was 27.8(25.3,30.3) at baseline and was significantly reduced at every interval (p of trend &lt; 0.001), including 11.4(7.4,15.4) at 1 year. Of the 39(70.9%) patients that were on a DA with augmentation at baseline, 32(82.1%) had discontinued DAs with 5(12.8%) on a reduced dose at the final visit. Of those remaining on bup at the final visit, 93.8% were CGI-I responders, There was a statistically significant longitudinal trend in 1-year improvement in ESS:9.9(8.0,11.8) to 6.9(4.5,9.4),p=0.003, ISI:18.0(15.9,20.1) to 15.0(11.6,18.3),p=0.048, PHQ-9:10.4(8.2,12.5) to 6.1(3.6,8.6),p&lt; 0.001, and PROMIS-SD:63.0(60.2,65.7) to 53.8(49.8,57.8),p&lt; 0.001. 13(23.6%) discontinued bup with nausea, cognitive complaints, and dizziness as the most common side effects.

Conclusion
In this largest cohort to date to examine buprenorphine in severe RLS, our findings show buprenorphine markedly reduced RLS symptoms, effectively enabled the elimination of dopamine agonists in patients with augmentation, improved sleep and other health quality measures, and was tolerated comparably to other RLS medications.

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0703 The burden of obstructive sleep apnoea and periodic limb movements during sleep on symptoms of parasomnia
Authors: Bikov Andras , Aleem Muhammad Saad , Morris Bryn 
Published: May 2023

Abstract

Introduction
Both obstructive sleep apnoea (OSA) and periodic limb movements during sleep (PLMS) may trigger arousals which could induce parasomnias. However, the burden of OSA and PLMS in parasomnia is not fully understood. The aim of the study was to understand the prevalence of OSA and PLMS and their association with symptoms of parasomnia in patients referred with parasomnia for an inpatient polysomnography (PSG).

Methods
In this retrospective project we analysed demographics, medical history and PSG data of 94 patients with parasomnia. The relationship between symptoms of parasomnia, OSA and PLMS were analysed with logistic regression analyses. Data are expressed as odds ratio /95% confidence intervals/.

Results
Forty-seven patients were diagnosed with OSA and 19 with PLMS. Parasomnia symptoms consisted dream enactment (n=28), abnormal movements (n=35), sleep talking (n=36), confusional arousals (n=27), sleep walking (n=36), night terrors (n=18), nightmares (n=15), sleep eating (n=8) and sexsomnia (n=2). Based on symptoms and PSG results, 45 were diagnosed with REM-parasomnia, 63 with non-REM parasomnia, 14 had overlap (both REM and non-REM parasomnia). Interestingly, non-REM parasomnias were inversely related to both OSA (-0.89 /-1.77-0.00/) and PLMS (-1.60 /-2,69- -0.55/, p&lt; 0.01). More particularly, OSA was less prevalent in patients with night terrors (-1.52 /-2.72- -0.32, p&lt; 0.01), whilst PLMS was more prevalent in patients with dream enactment (1.26 /0.21-2.30/, p=0.03), but was less prevalent in patients with nightmares (-2.30 /-5.164-0.56/, p=0.03), and with sleep walking (-1.96 /-3.49- -0.42/, p&lt; 0.01).

Conclusion
Both OSA and PLMS are prevalent in patients with parasomnia, however their association with specific diseases and symptoms is less evident. Further studies are necessary to understand if they could be treatable traits in parasomnias.

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0708 Systematic Review of Behavioral Treatments for NREM Parasomnias
Authors: Mundt Jennifer , Schuiling Matthew , Warlick Chloe , Wescott Annie , Hagenaars Muriel , Furst Ansgar , Baron Kelly 
Published: May 2023

Abstract

Introduction
NREM parasomnias are often benign and transient, requiring no formal treatment. However, parasomnias can also be chronic, disrupt sleep quality, and pose a significant risk of harm to the patient or others. Numerous behavioral strategies have been described for the management of NREM parasomnias, but there have been no published comprehensive reviews. This systematic review was conducted in order to summarize the range of behavioral interventions and their efficacy.

Methods
We conducted a systematic search of the literature to identify all publications describing behavioral treatment of NREM parasomnias (confusional arousals, sexsomnia, sleepwalking, sleep terrors, sleep-related eating disorder, parasomnia overlap disorder). The search was conducted on March 10, 2021 in the following databases: Ovid (MEDLINE), Cochrane Library databases (Wiley), CINAHL (EBSCO), and Web of Science (Clarivate). The search yielded 2411 records. After removing duplicates, 1703 unique records were screened. This yielded 159 publications for full-text review. While reviewing those publications, an additional 83 were identified for screening. Based on the full-text reviews, a total of 66 publications were included in the systematic review, including manuscripts in English (n=63), Dutch (n=2), and German (n=1).

Results
Most included manuscripts were case studies, case series, or retrospective chart reviews. There were only three randomized controlled trials. Children (&lt; 18 years) were included in 33 publications and adults were included in 36. Numerous behavioral strategies were reported, the most common being hypnosis (n=33) and various types of psychotherapy (n=26). Additional interventions included sleep hygiene (n=15), education/reassurance (n=13), relaxation (n=10), scheduled awakenings (n=9), and sleep extension or scheduled naps (n=8). In many studies, multiple interventions were trialed in combination. Length of follow-up varied considerably both within and between studies (range=0-9 years). Outcome measures were inconsistent across studies and some included only qualitative descriptions. Quantitative outcomes included the frequency of symptoms and patient ratings of symptom severity.

Conclusion
This review highlights the wide breadth of potential interventions for managing NREM parasomnias without medication. Randomized controlled trials are needed to determine which interventions are most efficacious, including which are best for particular disorders or ages. Future trials should include standardized quantitative measures of symptoms in order to allow comparison across trials.

Support (if any)
0709 Chronotype characteristics in restless legs syndrome
Authors: Lee Wankiun , Jung Ki-Young 
Published: May 2023

Abstract

Introduction
There are many people with a late chronotype in restless legs syndrome(RLS) patients. This phenomenon may be caused by sleep disturbance due to lower extremity symptoms of RLS, or it may be caused by some disease-specific characteristic of RLS, involving the circadian system. The aim of this study is to estimate the cause of this phenomenon.

Methods
This study is a retrospective study and was performed on 100 RLS patients without other major sleep disorders and 51 control subjects. Patients taking hypnotics such as benzodiazepines, melatonin, and zolpidem were also excluded. A survey on various sleep questionnaire scores was made for RLS patients. The questionnaire scores between the two groups were compared, and the collected data were analyzed with a significance level of 0.05.

Results
When the severity of RLS was evaluated by the IRLS score and the proportion of patients with late chronotype was checked by severity, it was 31.1% in the mild group, 41.7% in the moderate group, and 52.6% in the severe group(p=0.420). When the patient group with mild severity was compared with the entire patient group, the PSQI level was 82.0% of the total patient group(p=0.026).

Conclusion
RLS patients are more likely to have a late chronotype than those without RLS. The higher the severity of RLS symptoms, the higher the rate of having a late chronotype. Therefore, it could be inferred that the late chronotype identified in RLS patients was secondary to sleep disturbances caused by RLS symptoms.

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0716 Quality of Life in Idiopathic REM Sleep Behavior Disorder and Isolated REM Sleep Without Atonia
Authors: Barone Daniel , Sarva Harini , Wang Fei , Wu Zhenxing , Krieger Ana , Henchcliffe Claire 
Published: May 2023

Abstract

Introduction
Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) can affect quality of life (QOL) for both patient and bed partner; isolated REM sleep without atonia (iRSWA) has been less well-studied. We aimed to investigate whether QOL changes over time in those with either iRBD or iRSWA, as well as compare these changes to one another. Additionally, we attempted to demonstrate whether certain QOL changes were associated with phenoconversion to neurodegenerative illness.

Methods
We prospectively analyzed data from the “REM Sleep Behavior Disorder Associations with Parkinson’s Disease Study (RAPiDS)” cohort both at baseline and then at follow-up evaluations. We utilized the Neuro-QOL self-reported questionnaire to ascertain subjects’ level of QOL.

Results
There were 6 with iRSWA and 33 with iRBD, with an average age of 61.9 ± 13.0 years, with 13 women and 26 men. Significant QOL changes were found in both iRSWA and iRBD group. Among those who phenoconverted, fatigue and social functioning were the main QOL issues that that worsened over time.

Conclusion
This is the first time the Neuro-QOL has been studied in iRBD and iRSWA. QOL can be affected in both conditions; fatigue and social functioning seem to be of particular importance as they may be associated with phenoconversion.

Support (if any)
Grant from a private individual
0719 Association of subjective-objective discrepancy in sleep duration with all-cause mortality in community-dwelling older men
Authors: Utusumi Tomohiro , Yoshiike Takuya , Kaneita Yoshitaka , Aritake-Okada Sayaka , Matsui Kentaro , Nagao Kentaro , Saitoh Kaori , Otsuki Rei , Shigeta Masahiro , Suzuki Masahiro , Kuriyama Kenichi 
Published: May 2023

Abstract

Introduction
There is evidence for a mismatch between subjective and objective sleep durations not only in individuals with insomnia but also in healthy individuals . However, it is unclear how such discrepancy impacts long-term health outcomes. This study investigated whether and how the discrepancy between subjective and objective sleep duration affected all-cause mortality in a sample of community-dwelling older adult men, aged ≥ 65 years.

Methods
We conducted a secondary analysis of data obtained via the Osteoporotic Fractures in Men Sleep Study, a community-based, longitudinal, observational, and multicenter study. We included data from 2,674 individuals who underwent an in-home polysomnography, completed morning surveys to assess subjective sleep duration during the polysomnography, and for whom survival or death data were available. We assessed the longitudinal association between misperception index (MI), calculated as MI = (objective sleep duration – subjective sleep duration) / objective sleep duration, and all-cause mortality. MI was treated as both a continuous and categorical predictor: the lowest (≤ -0.19; the overestimation of sleep duration) and highest MI quartiles (&gt; 0.08; the underestimation of sleep duration) were compared to the interquartile range of MI (-0.19 &lt;, ≤ 0.08 ).

Results
During the follow-up with a mean (standard deviation) of 10.8 (4.2) years, 1,596 deaths (59.7%) were observed. As a continuous variable, MI showed a negative association with all-cause mortality after adjusting for multiple covariates, including polysomnography-measured objective sleep duration (fully adjusted hazard ratio [HR], 0.69; 95% confidence interval [CI], 0.56–0.84). As a categorical variable, the lowest MI quartile (vs. the interquartile MI range) was associated with increased mortality (fully adjusted HR, 1.28; 95% CI, 1.12–1.46), whereas the highest MI quartile was not associated with mortality (fully adjusted HR, 0.97; 95% CI, 0.85–1.11).

Conclusion
The subjective overestimation (“reverse” misperception) of sleep duration, may be a risk factor for all-cause mortality in older men. Further investigations are needed to examine physiological mechanisms through which subjective overestimation of sleep duration leads to negative long-term health outcomes.

Support (if any)
This work was supported by the Ministry of Health, Labor and Welfare, Government of Japan (Grant numbers #19FA1009 and #21FA1002).
0721 Power Nap or Cognitive Trap? Role of Age in Associations Between Napping and Cognition
Authors: Nowakowski Lauren , Costa Amy , McCrae Christina , Curtis Ashley 
Published: May 2023

Abstract

Introduction
How napping is associated with cognition is currently unclear with past work indicating napping benefits cognition for young adults and inconsistent findings regarding cognition in older adults. The present study improved upon previous literature by examining how age moderates associations between napping behaviors across a full week and both subjective and objective cognition across the adult lifespan.

Methods
Cognitively healthy adults aged 18-82 (N=134, Mage=41.43, SD=22.14, 115 females) completed assessments of napping habits across 7 days (naps per week, duration), and subjective cognition [Cognitive Failures Questionnaire (CFQ) total, sub-scores of CFQ-memory, CFQ-distractibility, and CFQ-blunders]. A sub-set of participants (N=105) also completed objective cognitive tasks: Stroop (inhibition, attention, processing speed), Posner Cueing (attentional orienting), Sternberg (working memory), and Wisconsin Card Sorting (executive function). Multiple regression and Johnson-Neyman analyses evaluated the moderating impact of age on associations between napping and cognition, controlling for sex, anxiety and depression symptoms, and sleep and pain medication usage.

Results
Age moderated the relationship between nap duration and CFQ-total (R2-change=.02, p=.04), CFQ-memory (R2-change=.04, p=.01), and CFQ-blunders (R2-change=.06, p=.01). Specifically, longer nap duration was associated with fewer global cognitive complaints at age 20 and below (B=-.08, SE=.04, p=.049), more memory complaints at age 69 and above (B=.08, SE=.04, p=.05), as well as more blunder complaints at age 47 and above (B=.05, SE=.02, p=.048).

Conclusion
Findings suggest longer naps are associated with worse subjective cognition in older adults and better subjective cognition in younger adults. Similar patterns were not observed in middle-aged adults or for objective cognition. More work is needed to understand how the potential cognitive restorative impact of napping in younger adults may be disrupted in older adults. Given known associations between subjective cognition and future cognitive impairment, prospective studies should determine if napping is a key indicator of potential future cognitive decline in aging adults and explore underlying age-related mechanisms in this relationship such as systemic inflammation and changes in

Support (if any)
This work was supported by the American Academy of Sleep Medicine Foundation (NCT0282642; AASM Award #: 212-FP-19 PI: Curtis, a foundation of the American Academy of Sleep Medicine).