bluuebunny/crossref_metadata_2025_split huggingface dataset:
(105) The Discovery of New Incredible Positive Actions of Hormone Replacement Therapy and Sex in Menopause
Authors: Dominguez-Bali A , Baqer A , Hassan Z , Sharma R , Dominguez-Bali C , Marquez L 
Published: May 2023

Abstract

Introduction
Every year, two or more benefits of the use of hormone replacement therapy (HRT) in menopause and andropause appear in medical literature. We present an extensive review of the literature describing the classical and novel benefits of hormonal replacement therapy and sex in menopause. Additionally, we present recent findings from our own patient population.

Objective
To contribute to the presently known benefits of the use of HRTs, and additionally to present new findings from our own practice not previously described.

Methods
We conducted an extensive literature review and described our own experience and findings within our centers.

Results
`- In the area of prevention and treatment of genitourinary syndrome of menopause, we have found: - Prevention and treatment of false positive cervical dysplasia in perimenopause. - Prevention and treatment of vulvar, labial, and vaginal occlusion in late menopause. - Prevention and treatment of recurrent urinary tract infections in geriatric patients for prevention of sepsis, secondary pneumonia, and even death. - Prevention and treatment of clitoral atrophy, phimosis, and urethral caruncles - Dermatology: We have found: - Prevention and treatment of wrinkles, alopecia related, postmenopause. - Prevention in prostrated geriatric patients of decubitus ulcers. - Internal Medicine: prevention of obesity, decreased metabolic rate, and insulin resistance. - Ophthalmology: - Prevention and treatment of macular degeneration. - Prevention of glaucoma (increased intraocular pressure), most notably in primary open- angle glaucoma. - The prevention of aging of optic nerve and neuroprotection of retinal cells. - Oncology: - Prevention of kidney cancers, and breast cancer (only estrogen hormone replacement therapy). - Enhanced visualization of the transformation zone during cervical cancer screening - Gastroenterology: protection of the gut microbiome and serum metabolome, especially in premature ovarian insufficiency - Dentistry: prevention of tooth loss through decreased gingival inflammation and periodontitis, mandibular bone loss, and oral dysesthesia. - Neurology: - Protection against intracranial aneurysm rupture in ovariectomized mice. - The prevention of Parkinson’s and Alzheimer’s disease - Rheumatology: prevention of rheumatoid arthritis.

Conclusions
To demonstrate the number of studies with the anti-aging mechanism of the use of HRT. How this knowledge, alongside our own findings of hundreds of menopausal women within our centers justify the generalized use of this therapy.

Disclosure
No
(128) Pelvic Pain in Tarlov Cyst: Pathognomony in Gender Inequality
Authors: Choucroun D , Kone Groot N 
Published: May 2023

Abstract

Introduction
The production of knowledge having long been the prerogative of men, scientific research and patients care are still largely unequal in the field of medecine and surgery: the construction of a weak, spontaneously painful female nature is accepted as a cause of the historical delay of 130 years in the diagnosis of endometriosis. but who knows Tarlov cysts, getting lost in a maze of protean urogenital and somatic symptoms? Pelvic pain leads always to the search for a local cause by examination, ultrasounds, sometimes MRI as well as biological explorations. At least, if nothing is found, the pain is mainly attributed to depression, whereas depression is a consequence of this chronic pain and lack of adequate care.

Objective
To be able to identify symptomatic Tarlov cysts in front of pelvic pain with or without other various symptoms. -in presence of unexplained pelvic pain, urogenital or sexual symptoms without local cause and without compatible clinical features such a Marfan syndrome, neurofibromatosis, Ehlers Danlos, other -especially if it exists urinary or sphincters disorders -knowing that Tarlov cyst can become symptomatic after childbirth -know that when discovered incidentally, an asymptomatic Tarlov cyst does not usually require treatment

Methods
Literature review on PubMed for the last ten years

Results
For the last ten years we found only eleven relevant results for the keywords Tarlov cyst and pelvic pain and Tarlov cyst and adnexal mass: in the presence of atypical or persistent pelvic pain the differential diagnosis occurs at four levels: -pain persists despite the treatment of a first etiology -a large Tarlov cyst can mimic an adnexal mass, although this is very rare, with only twelve cases described so far -gaining the patient's trust may lead her to describe the persistent genital arousal disorder, that is unwanted, intrusive and sometimes painful sensation of genital arousal, more than 60% of these patients would have a Tarlov cyst according to some authors. -Some symptoms such as early sensation of bladder filling, or urinarybladder or lumosacral symptoms might be overlooked by the patient herself, making diagnosis more difficult.

Conclusions
Tarlov cysts are extradural menigeal cysts, usually at the sacral level of the spine. their prevalence can reach up 13% of the population, and is largely female, 75 to 90% of the described cases, may be explained by thinner meninges in women compared to men and by the tilt of the pelvis, providing a stress on the spine. 1% of Tarlov cysts are symptomatic and require a specific,,usually surgical, treatment. This work has limitations in particular because of a poor literature about this subject, but highlights: - the importance of a neurological opinion in front of pleiomorphic female pelvic symptoms - the lack of scientific research for an essentially female pathology.

Disclosure
No
(130) Marsupialization of the Bartholin Duct Cyst and Recanalization for Symptomatic Recurrent Bartholin Cysts
Authors: Yee A , Goldstein I 
Published: May 2023

Abstract

Introduction
Bartholin glands (BGs) are located posteriorly on each side of the vaginal introitus. During sexual arousal, BGs release mucinous secretions into the vestibule at the 5:00 and 7:00 positions via a 2.5 cm Bartholin duct (BD). The BD may become obstructed from trauma, inflammation, infection, vestibular or vulvar surgery, or idiopathic factors. Despite BD obstruction, the glands may continue to produce mucinous secretion causing cystic dilation of the duct. Thus, a Bartholin duct cyst (BC) is formed and can result in pain during sexual arousal. Treatment strategies include sitz baths, hot compresses, aspiration, Word catheter placement, or BC marsupialization.

Objective
This chart review was performed to assess the safety and efficacy of a new technique for BD marsupialization in patients with symptomatic BC.

Methods
This is a chart review of patients with symptomatic BC who underwent BD marsupialization using a new technique. This new strategy involves marsupialization of the anterior wall of the BC, identification of the BD lumen on the posterior wall of the BC under surgical Loupes magnification and advancement of the BD lumen directly to the surface of the introitus at 5:00 and/or 7:00 locations. The BD neo-ostium was secured with interrupted 4.0 chromic sutures.

Results
14 patients (mean age 28 ± 9 years) between 2015 - 2022 diagnosed with recurrent BC-induced pain during sexual arousal were treated by marsupialization of the BC and advancement of the BD directly to the mucosal surface of the introitus. Each patient averaged 3 prior BC treatments (range 0- 6). Symptoms included pain with sexual arousal or walking/sitting (100%) and an introitus mass interfering with penetration (50%). The mean BC size on ultrasound was 2.7 ± 1.6 cm x 2.4 ± 1.7 cm. All BD marsupialization surgeries were performed as outpatient procedures. Sexual arousal was encouraged early post-operatively and mucinous secretion documented by vestibular photography post-arousal. With an average follow-up of 14 months, 11/14 (79%) symptomatic BCs have resolved.

Conclusions
A new surgical strategy is described for patients with symptomatic BCs involving BD anastomosis directly to the introital mucosa at the 5:00 or 7:00 locations, resolution of BD obstruction, and excellent restoration of BG lubrication.

Disclosure
No
Disc flaring with TNG50: diversity across Milky Way and M31 analogues
Authors: Sotillo-Ramos Diego , Donnari Martina , Pillepich Annalisa , Frankel Neige , Nelson Dylan , Springel Volker , Hernquist Lars 
Published: May 2023

ABSTRACT
We use the sample of 198 Milky Way (MW) and Andromeda (M31) analogues from TNG50 to quantify the level of disc flaring predicted by a modern, high-resolution cosmological hydrodynamical simulation. Disc flaring refers to the increase of vertical stellar disc height with galactocentric distance. The TNG50 galaxies are selected to have stellar discy morphology, a stellar mass in the range of M* = 1010.5–11.2 M⊙, and an MW-like Mpc-scale environment at z = 0. The stellar discs of such TNG50 MW/M31 analogues exhibit a wide diversity of structural properties, including a number of galaxies with disc scale length and thin and thick disc scale heights that are comparable to those measured or inferred for the Galaxy and Andromeda. With one set of physical ingredients, TNG50 returns a large variety of flaring flavours and amounts, also for mono-age stellar populations. With this paper, we hence propose a non-parametric characterization of flaring. The typical MW/M31 analogues exhibit disc scale heights that are 1.5–2 times larger in the outer than in the inner regions of the disc for both old and young stellar populations, but with a large galaxy-to-galaxy variation. Which stellar population flares more, and by how much, also varies from galaxy to galaxy. TNG50 de facto brackets existing observational constraints for the Galaxy and all previous numerical findings. A link between the amount of flaring and the z = 0 global galaxy structural properties or merger history is complex. However, a connection between the scale heights and the local stellar vertical kinematics and gravitational potential is clearly in place.
Parallel and perpendicular alignments of velocity gradient and magnetic field observed in the molecular clouds L1478 and L1482
Authors: Schmaltz Tyler , Hu Yue , Lazarian Alex 
Published: May 2023

ABSTRACT
Star formation is a complex process that typically occurs in dense regions of molecular clouds mainly regulated by magnetic fields, magnetohydrodynamic (MHD) turbulence, and self-gravity. However, it remains a challenging endeavour to trace the magnetic field and determine regions of gravitational collapse, where the star is forming. Based on the anisotropic properties of MHD turbulence, a new technique termed velocity gradient technique (VGT) has been proposed to address these challenges. In this study, we apply the VGT to two regions of the giant California Molecular Cloud (CMC), namely, L1478 and L1482, and analyse the difference in their physical properties. We use the 12CO (J = 2–1), 13CO (J = 2–1), and C18O (J = 2–1) emission lines observed with the Heinrich Hertz Submillimeter Telescope. We compare VGT results calculated in the resolutions of 3.3 and 10 arcmin to Planck polarization at 353 GHz and 10 arcmin to determine areas of MHD turbulence dominance and self-gravity dominance. We show that the resolution difference can introduce misalignment between the two measurements. We find the VGT-measured magnetic fields globally agree with those from Planck in L1478, suggesting self-gravity’s effect is insignificant. The best agreement appears in VGT-12CO. As for L1482, the VGT measurements are statistically perpendicular to the Planck polarization indicating the dominance of self-gravity. This perpendicular alignment is more significant in VGT-13CO and VGT-C18O.
Analyses of overlapping gravitational wave signals using hierarchical subtraction and joint parameter estimation
Authors: Janquart Justin , Baka Tomasz , Samajdar Anuradha , Dietrich Tim , Van Den Broeck Chris 
Published: May 2023

ABSTRACT
In the coming years, third-generation detectors such as Einstein Telescope and Cosmic Explorer will enter the network of ground-based gravitational-wave detectors. Their current design predicts a significantly improved sensitivity band with a lower minimum frequency than existing detectors. This, combined with the increased arm length, leads to two major effects: the detection of more signals and the detection of longer signals. Both will result in a large number of overlapping signals. It has been shown that such overlapping signals can lead to biases in the recovered parameters, which would adversely affect the science extracted from the observed binary merger signals. In this work, we analyse overlapping binary black hole coalescences with two methods to analyse multisignal observations: hierarchical subtraction and joint parameter estimation. We find that these methods enable a reliable parameter extraction in most cases and that joint parameter estimation is usually more precise but comes with higher computational costs.
Awesome SOSS: atmospheric characterization of WASP-96 b using the JWST early release observations
Authors: Taylor Jake , Radica Michael , Welbanks Luis , MacDonald Ryan J , Blecic Jasmina , Zamyatina Maria , Roth Alexander , Bean Jacob L , Parmentier Vivien , Coulombe Louis-Philippe , Feinstein Adina D , Espinoza Néstor , Benneke Björn , Lafrenière David , Doyon René , Ahrer Eva-Maria 
Published: May 2023

ABSTRACT
The newly operational JWST offers the potential to study the atmospheres of distant worlds with precision that has not been achieved before. One of the first exoplanets observed by JWST in the summer of 2022 was WASP-96 b, a hot Saturn orbiting a G8 star. As a part of the Early Release Observations programme, one transit of WASP-96 b was observed with NIRISS/SOSS to capture its transmission spectrum from 0.6 to 2.85 μm. In this work, we utilize four retrieval frameworks to report precise and robust measurements of WASP-96 b’s atmospheric composition. We constrain the logarithmic volume mixing ratios of multiple chemical species in its atmosphere, including: H2O = $-3.59 ^{+ 0.35 }_{- 0.35 }$, CO2 = $-4.38 ^{+ 0.47 }_{- 0.57 }$, and K = $-8.04 ^{+ 1.22 }_{- 1.71 }$, thus generally consistent with 1× solar (with the exception of CO2). Notably, our results offer a first abundance constraint on potassium in WASP-96 b’s atmosphere and important inferences on carbon-bearing species such as CO2 and CO. Our short wavelength NIRISS/SOSS data are best explained by the presence of an enhanced Rayleigh scattering slope, despite previous inferences of a clear atmosphere – although we find no evidence for a grey cloud deck. Finally, we explore the data resolution required to appropriately interpret observations using NIRISS/SOSS. We find that our inferences are robust against different binning schemes. That is, from low R = 125 to the native resolution of the instrument, the bulk atmospheric properties of the planet are consistent. Our systematic analysis of these exquisite observations demonstrates the power of NIRISS/SOSS to detect and constrain multiple molecular and atomic species in the atmospheres of hot giant planets.
Rotation-tunnelling spectrum and astrochemical modelling of dimethylamine, CH3NHCH3, and searches for it in space
Authors: Müller H S P , Garrod R T , Belloche A , Rivilla V M , Menten K M , Jiménez-Serra I , Martín-Pintado J , Lewen F , Schlemmer S 
Published: May 2023

ABSTRACT
Methylamine has been the only simple alkylamine detected in the interstellar medium for a long time. With the recent secure and tentative detections of vinylamine and ethylamine, respectively, dimethylamine has become a promising target for searches in space. Its rotational spectrum, however, has been known only up to 45 GHz until now. Here we investigate the rotation-tunnelling spectrum of dimethylamine in selected regions between 76 and 1091 GHz using three different spectrometers in order to facilitate its detection in space. The quantum number range is extended to J = 61 and Ka = 21, yielding an extensive set of accurate spectroscopic parameters. To search for dimethylamine, we refer to the spectral line survey ReMoCA carried out with the Atacama Large Millimeter/submillimeter Array towards the high-mass star-forming region Sagittarius B2(N) and a spectral line survey of the molecular cloud G+0.693–0.027 employing the IRAM 30 m and Yebes 40 m radio telescopes. We report non-detections of dimethylamine towards the hot molecular cores Sgr B2(N1S) and Sgr B2(N2b) as well as G+0.693−0.027 which imply that dimethylamine is at least 14, 4.5, and 39 times less abundant than methylamine towards these sources, respectively. The observational results are compared to computational results from a gas-grain astrochemical model. The modelled methylamine to dimethylamine ratios are compatible with the observational lower limits. However, the model produces too much ethylamine compared with methylamine which could mean that the already fairly low levels of dimethylamine in the models may also be too high.
Fuelling the nuclear ring of NGC 1097
Authors: Sormani Mattia C , Barnes Ashley T , Sun Jiayi , Stuber Sophia K , Schinnerer Eva , Emsellem Eric , Leroy Adam K , Glover Simon C O , Henshaw Jonathan D , Meidt Sharon E , Neumann Justus , Querejeta Miguel , Williams Thomas G , Bigiel Frank , Eibensteiner Cosima , Fragkoudi Francesca , Levy Rebecca C , Grasha Kathryn , Klessen Ralf S , Kruijssen J M Diederik , Neumayer Nadine , Pinna Francesca , Rosolowsky Erik W , Smith Rowan J , Teng Yu-Hsuan , Tress Robin G , Watkins Elizabeth J 
Published: May 2023

ABSTRACT
Galactic bars can drive cold gas inflows towards the centres of galaxies. The gas transport happens primarily through the so-called bar dust lanes, which connect the galactic disc at kpc scales to the nuclear rings at hundreds of pc scales much like two gigantic galactic rivers. Once in the ring, the gas can fuel star formation activity, galactic outflows, and central supermassive black holes. Measuring the mass inflow rates is therefore important to understanding the mass/energy budget and evolution of galactic nuclei. In this work, we use CO datacubes from the PHANGS-ALMA survey and a simple geometrical method to measure the bar-driven mass inflow rate on to the nuclear ring of the barred galaxy NGC 1097. The method assumes that the gas velocity in the bar lanes is parallel to the lanes in the frame co-rotating with the bar, and allows one to derive the inflow rates from sufficiently sensitive and resolved position–position–velocity diagrams if the bar pattern speed and galaxy orientations are known. We find an inflow rate of $\dot{M}=(3.0 \pm 2.1)\, \rm M_\odot \, yr^{-1}$ averaged over a time span of 40 Myr, which varies by a factor of a few over time-scales of ∼10 Myr. Most of the inflow appears to be consumed by star formation in the ring, which is currently occurring at a star formation rate (SFR) of $\simeq\!1.8\!-\!2 \, \rm M_\odot \, yr^{-1}$, suggesting that the inflow is causally controlling the SFR in the ring as a function of time.
Whole-cell modeling of E. coli confirms that in vitro tRNA aminoacylation measurements are insufficient to support cell growth and predicts a positive feedback mechanism regulating arginine biosynthesis
Authors: Choi Heejo , Covert Markus W 
Published: May 2023

Abstract
In Escherichia coli, inconsistencies between in vitro tRNA aminoacylation measurements and in vivo protein synthesis demands were postulated almost 40 years ago, but have proven difficult to confirm. Whole-cell modeling can test whether a cell behaves in a physiologically correct manner when parameterized with in vitro measurements by providing a holistic representation of cellular processes in vivo. Here, a mechanistic model of tRNA aminoacylation, codon-based polypeptide elongation, and N-terminal methionine cleavage was incorporated into a developing whole-cell model of E. coli. Subsequent analysis confirmed the insufficiency of aminoacyl-tRNA synthetase kinetic measurements for cellular proteome maintenance, and estimated aminoacyl-tRNA synthetase kcats that were on average 7.6-fold higher. Simulating cell growth with perturbed kcats demonstrated the global impact of these in vitro measurements on cellular phenotypes. For example, an insufficient kcat for HisRS caused protein synthesis to be less robust to the natural variability in aminoacyl-tRNA synthetase expression in single cells. More surprisingly, insufficient ArgRS activity led to catastrophic impacts on arginine biosynthesis due to underexpressed N-acetylglutamate synthase, where translation depends on repeated CGG codons. Overall, the expanded E. coli model deepens understanding of how translation operates in an in vivo context.
Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling
Authors: Kejiou Nevraj S , Ilan Lena , Aigner Stefan , Luo Enching , Tonn Tori , Ozadam Hakan , Lee Muyoung , Cole Gregory B , Rabano Ines , Rajakulendran Nishani , Yee Brian A , Najafabadi Hamed S , Moraes Trevor F , Angers Stephane , Yeo Gene W , Cenik Can , Palazzo Alexander F 
Published: May 2023

Abstract
In light of the numerous studies identifying post-transcriptional regulators on the surface of the endoplasmic reticulum (ER), we asked whether there are factors that regulate compartment specific mRNA translation in human cells. Using a proteomic survey of spatially regulated polysome interacting proteins, we identified the glycolytic enzyme Pyruvate Kinase M (PKM) as a cytosolic (i.e. ER-excluded) polysome interactor and investigated how it influences mRNA translation. We discovered that the PKM-polysome interaction is directly regulated by ADP levels–providing a link between carbohydrate metabolism and mRNA translation. By performing enhanced crosslinking immunoprecipitation-sequencing (eCLIP-seq), we found that PKM crosslinks to mRNA sequences that are immediately downstream of regions that encode lysine- and glutamate-enriched tracts. Using ribosome footprint protection sequencing, we found that PKM binding to ribosomes causes translational stalling near lysine and glutamate encoding sequences. Lastly, we observed that PKM recruitment to polysomes is dependent on poly-ADP ribosylation activity (PARylation)—and may depend on co-translational PARylation of lysine and glutamate residues of nascent polypeptide chains. Overall, our study uncovers a novel role for PKM in post-transcriptional gene regulation, linking cellular metabolism and mRNA translation.