bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of primary debulking surgery and neoadjuvant chemotherapy plus interval debulking surgery for epithelial ovarian cancer with extra-abdominal metastasis
Authors: Jiang Qidi , Zou Ruoyao , Chen Mo , Yuan Lei , Bao Yiting , Yao Liangqing 
Published: January 2023

Abstract
Background

Primary debulking surgery (PDS) or neoadjuvant chemotherapy with interval debulking surgery (NACT-IDS) was the standard treatment for advanced ovarian cancer. Optimal cytoreduction is believed one of the most important factors for survival. However, in patients with extra-abdominal metastases which is impossible to achieve optimal cytoreduction around whole body, which treatment should be used is not clear yet.

Methods

Patients with stage IV epithelial ovarian cancer with extra-abdominal metastases who underwent primary treatment between January 1, 2015 and January 31, 2022 were identified. Data were retrospectively extracted. Each patient record was evaluated to subclassify stage IV disease according to the sites of metastases at the time of diagnosis. Kaplan-Meier plot and Log-rank test were used to analyze the difference between two groups. Univariate and multivariate Cox regression analysis were used to identify important prognostic factors.

Results

A total of 72 newly diagnosed stage IV epithelial ovarian cancer patients were included, in which 36 (50%) patients underwent PDS, 36 (50%) patients underwent NACT-IDS. The median overall survival was significantly longer in PDS group than NACT-IDS group (51.3 months vs. 36 months, p = 0.027). Patients receiving PDS has significantly longer progression-free survival than who received NACT-IDS (21.6 months vs. 14.3 months, p = 0.049). The rate of no residual disease was higher in patients with NACT-IDS versus PDS (61% vs. 44%). The complete response rate was significantly higher in PDS group than NACT group (83% vs. 67%, p = 0.013) after PDS/IDS and full course of chemotherapy. Women who received PDS had a trend toward a higher rate of grade III/IV postoperative complications than those who received NACT (25% vs. 6%, p = 0.046).

Conclusions.

PDS for epithelial ovarian cancer patients with extra-abdominal metastasis resulted in longer OS and PFS than NACT + IDS. Cytoreduction to no residual disease in the interval debulking surgery should be the goal in patients who receive NACT.
Using rice bran for encapsulating probiotic and by different methods to produce synbiotic powder which can be tolerance gastrointestinal condition, application in health products.
Authors: Tianwitawat Chanika , Klaiprasitti Patimakorn 
Published: January 2023

Abstract
Several consumers who have been interested in Lactic acid bacteria for healthy food are higher due to awareness of the probiotic’s role. Several studies have presented stress adaptation of single probiotic strains, but the comparison of stress-tolerant capacity between probiotic strains have not been completely investigated. Five lactic acid cultures were tested for adaptation in four sub-lethal conditions, including heat, cold, acidity and bile salt. Lactobacillus casei is found to be the most resilient probiotic from heat and cold adaptation, while Lactobacillus acidophilus is more tolerant to low acid and bile salt. Then these probiotics were subjected to the stress challenge that stimulated drying temperature, inclusive of heat challenge at 72°C for 15 seconds and cold challenge at -60°C for 48 hours. The results showed that acid adaptation can improve Lactobacillus acidophilus TISTR 1338 as the highest tolerance for both harsh drying temperature due to the major brand protein involved in stress adaptation that are DnaK and GrpE. Acid-adapted L. acidophilus TISTR 1338 at the sub-lethal is able to be applied to high and low temperature processing. In addition, it was found that the encapsulation using prebiotic extracts from rice bran combined with pectin and resistant starch in the crosslinking technique treated by freeze-drying method provides the highest encapsulation efficiency or more than 90%. Also, the amount of survivable probiotic after via gastrointestinal tract remained 5 LogCFU/g, which is suitable for application in the production of synbiotic cold brew coffee.
Nd:YAG 1064-nm laser for residual infantile hemangioma after propranolol treatment
Authors: Khamaysi Ziad , Pam Nadav , Zaaroura Hiba , Avitan-Hersh Emily 
Published: January 2023

AbstractBackground:Infantile hemangiomas (IH) arecommon benign tumors of infancy. Most IH involute, either spontaneously, or secondary to pharmacological treatment with systemic propranolol. Propranolol treatment mostly leads to regression of hemangiomas with satisfactory aesthetic results, but unfortunately not in all cases.Objective:To assess the safety and efficacy of long pulsed Nd:YAG 1064 nm laser in treating patients with residual infantile hemangioma after systemic propranolol treatment.Patients and methods:This is an open-label prospective cohort study. 30 patients with focal residual IH that had sub-optimal responses to systemic propranolol treatment were enrolled in the study. The patients were treated with 1 to 3 sessions with long pulsed Nd: YAG 1064 nm laser. The maximal response of the IH was assessed using a 4-point scale evaluation scale system.Results:Of the 30 patients enrolled, 18 patients exhibited a great response (>76% improvement), 10 patients had a good response (>51-75% improvement), while only 2 patients showed a moderate response (<50% improvement) to the treatment. No patients had an unsatisfactory response. No serious side effects were observed, and only minor side effects were reported.Conclusions:The treatment with long pulsed Nd:YAG 1064 nm laser for residual IH, which were resistant to systemic propranolol treatment, is safe and effective. Thus, we suggest its use as a second-line treatment for patients with sub-optimal aesthetic results following systemic propranolol.
The Evaluation of Pre-Extubation Vital Signs as Indicators for Extubation Failure in ICU Patients
Authors: Schwier Corrine P , Ozaki Haruka 
Published: January 2023

Abstract
Objective:

This retrospective study analyzes patient vital sign averages during intubation and compares them to 1-hour pre-extubation vital sign averages. Data from 7,185 ICU admissions were compiled from the MIMIC-IV database. Vital signs include heart rate, systolic and diastolic blood pressure, respiratory rate, blood oxygen level (SpO2), temperature, and glucose levels.

Results:

There were significant differences between the extubation success (ES) and failure (EF) groups both in their intubation averages and 1-hour pre-extubation averages. ES patients’ respiratory rates increased 1-hour prior to extubation, while EF patients did not demonstrate a marked change. In combination with decreased SpO2, the lack of change in respiratory rate can be a good indicator that a patient experience EF.
The results of this study suggest that there are marked changes in patient vital signs 1-hour pre-extubation compared to their total intubation averages between patients that are successfully extubated and those that require reintubation.
Trends and age-period-cohort effect on dental caries prevalence from 2008 to 2019 among Brazilian pre-school children
Authors: Ramadan Yassmín Hêllwaht , Knorst Jessica Klöckner , Brondani Bruna , Agostini Bernardo Antonio , Ardenghi Thiago Machado 
Published: January 2023

Abstract
Aim: This study aimed to evaluate trends in the prevalence of dental caries in preschool children and associated factors considering different time variations.
Methods: This is a time seriesstudy performed using data from three cross-sectional studies with pre-school children from southern Brazil in 2008, 2013 and 2019. Dental caries was evaluated by decayed, missing and filled deciduous teeth (dmft index). Demographic, socioeconomic, behavioural and psychosocial variables were also collected. Chi-square test for trends and a hierarchical age-period-cohort (HAPC) analysis using multilevel Poisson regression model for testing the associations between predictor variables and dental caries experience were used.
Results: A total of 1,644 pre-school children participated in all surveys. There was a significant difference in caries experience considering all APC effects. The prevalence of dental caries was 25.0% in 2008, 16.3% in 2013, and 19.4% in 2019 and no statistical difference was observed. An age effect showed that older children were more likely to experience dental caries. Considering the cohort effect, there is a significant difference between the generations, mainly between 2003 and 2018. Household income, use of dental services, and parent’s perception of child oral health were associated with dental caries experience no matter the time variation.
Conclusion: Despite recent declines in dental caries prevalence among preschool children, caries levels increased with age and social inequalities persisted through the years, indicating a need of reviewing the policies to reduce the burden of this oral disease.
Clinical relevance: Our findings reinforce that the common risk factors still represent the best predictor for dental caries trends.
Effect of methyl orange and Evans blue functional groups on photocatalytic activities of different magnetite nanoparticle surfaces
Authors: Ahmouda Kaouthar , Boudiaf Moussa , Barani Djamel 
Published: January 2023

Abstract
The aim of this paper is to study the effect of Evans blue (EB) and methyl orange
(MO) functional group contents on the photocatalytic activities of four magnetite nanoparticle surfaces under UV-Vis (365 nm) in ambient conditions against the photodegradation of EB and MO. For this purpose, the adsorption has been conducted, at first, in dark ambient conditions to eliminate the effect of adsorption. The residual solutions of dye/magnetite were then used for photocatalytic reactions of the free functional groups of MO and EB on the four magnetite surfaces. The novelty of this paper lies in the demonstration of the effect of EB and MO functional groups on photocatalytic activities of magnetite nanoparticles (NPs) through the electron-hole pair’s interactions with dyes functional groups translated by the photoactivation of the Br ̈onsted and Lewis acid sites on the magnetite NPs. The results found show that MO photodegradation capacities and rates are higher than those of EB on the four magnetite surfaces, this is probably due to a large number of chromophores and auxochromes present in MO initial residual solutions. This is related to the effect of chromophore and auxochrome contents on the photoactivation of Br ̈onsted and Lewis acid sites. High chromophore and auxochrome contents in MO residual solutions further promote the photoactivation of Br ̈onsted and Lewis acid sites, resulting in the greater formation of trapped-electron and trapped-hole sites. The latter will then photoreduce more chromophores and photooxidize more auxochromes, respectively, which leads to an increase in the photocatalytic activity of magnetite surfaces.
The expression of Galectins-8 and its effect on neuroinflammation after intracerebral hemorrhage
Authors: JingjingSong  , JiyuLou  , ChaoJiang  , HongyingBai  , SiChen  , YuanyuanXing  
Published: January 2023

Abstract
At present, there is no effective treatment for secondary brain injury caused by spontaneous intracerebral hemorrhage (ICH). This study aims to explore new therapeutic targets after ICH. Galectins-8 is a tandem repeat galectin with a unique preference for α2,3-sialylated glycans, and its expression is ubiquitous. Gal − 8 regulates cytokine production, cell adhesion, apoptosis, chemotaxis, endocytosis, differentiation and migration, including immune cells. We used wild-type(WT)C57BL/6J mice and the mice of Galectins-8 gene knockout to establish intracerebral hemorrhage model by collagenase injection and found that Galectins-8 was highly expressed around the hematoma and in the center site of the hematoma after intracerebral hemorrhage. We also found that inhibiting the expression of Galectins-8 or Galectins-8 gene knockout mice may attenuate secondary brain injury following intracerebral hemorrhage by reducing microglia-induced inflammatory responses. Galecectin-8 knockout mice had significantly reduced expression of inflammatory factors, such as TNF-α(P = 0.0353), MCP-1(P = 0.0469), and HMBG1(P = 0.0466). This is in contrast to previous studies that have suggested Galectins-8 as a neuroprotective factor. From this, we draw a conclusion that Galectins-8 played an crucial role in regulating the inflammatory response during intracerebral hemorrhage. Our study highlights Galectins-8 as a potential therapeutic target to protect the brain against secondary brain damage during intracerebral hemorrhage.
Identifying Diagnostic Biomarkers of Breast Cancer Based on Gene
Expression Data and Ensemble Feature Selection
Authors: Li Lingyu , Algabri Yousif A. , Liu Zhi-Ping 
Published: January 2023

Background:
In recent years, the identification of biomarkers or signatures based on gene expression profiling data has attracted much attention in bioinformatics. The successful discovery of breast cancer (BRCA) biomarkers will be beneficial in reducing the risk of BRCA among patients for early detection.

Methods:
This paper proposes an Ensemble Feature Selection method to screen biomarkers (abbreviat-ed as EFSmarker) for BRCA from publically available gene expression data. Firstly, we employ twelve filter feature selection methods, namely median, variance, Chi-square, Relief, Pearson and Spearman correlation, mutual information, minimal-redundancy-maximal-relevance criterion, ridge regression, decision tree and random forest with Gini index and accuracy index, to calculate the importance (weights or coefficients) of all features on the training dataset. Secondly, we apply the logistic regres-sion classifier on the test dataset to calculate the classification AUC value of each feature subset indi-vidually selected by twelve methods. Thirdly, we provide an ensemble feature selection method by ag-gregating feature importance with classification AUC value. In particular, we establish a feature im-portance score (FIS) to evaluate the importance of each feature underlying all feature selection methods. Finally, the features with higher FIS are taken as identified biomarkers.

Results:
With the direction of the FIS index induced by the EFSmarker method, 12 genes (COL10A1,
COL11A1, MMP11, LOC728264, FIGF, GJB2, INHBA, CD300LG, IGFBP6, PAMR1, CXCL2 and
FXYD1) are regarded as diagnostic biomarkers for BRCA. Especially, COL10A1, ranked first with a
FIS value of 0.663, is identified as the most credible biomarker. The findings justified via gene and protein
expression validation, functional enrichment analysis, literature checking and independent dataset
validation verify the effectiveness and efficiency of these selected biomarkers.

Conclusion:
Our proposed biomarker discovery strategy not only utilizes the feature contribution but also considers the prediction accuracy simultaneously, which may also serve as a model for identifying unknown biomarkers for other diseases from high-throughput gene expression data. The source code and data are available at https://github.com/zpliulab/EFSmarker.
Urothelial bladder cancer in young age group: Presentation, clinical behavior and outcome
Authors: Hashim Saeed Pishtewan , Abdullah Ahmed Bayar 
Published: January 2023

Objectives: The main aim of our study is to review the clinical presentation, histopathological features, staging and grading, as well as the recurrence, and progression (for 1 year) of UBC in patients less than 40 years age.
Methods: We retrospectively reviewed records of 42 newly diagnosed patients with UBC between May 2016 to May 2020 at the Rizgary Teaching hospital, and Zheen International hospital in Erbil city, Iraq.
Results: The mean age ± SD of the sample were 29.05 ± 7.05 years, ranging from 17 to 39 years. The median was 28.5 years. Patients were divided into three groups, Group I (6 patients) were aged ≤ 20 years, Group II (17 patients) were aged between 20-29 years old, and Group III (19 patients) were aged between 30-39 years old. The majority (78.6%) of the cases were males. Gross hematuria (73.8%) is the most common presenting symptom. The proportion of smoker patients was 61.9%. Significantly higher proportions of patients with lower grade and stage and small tumor size were detected that comparable with previous studies that support the bladder cancer in young-aged group with lower grade and stage. In one year follow up, the recurrence occurred in 6 (14.3%) of patients, just 2 of them progressed to a higher grade or stage.
Conclusion: The results suggested that young patients with UBC was expecting better prognosis than older patients.
Frontiers in early detection of hepatocellular carcinoma
Authors: Mohie Abdel-Hamid Nabil , Abd Almunim Baker Luma , Farhan Bdaiwi Lelas 
Published: January 2023

Description of the article
The need for more precise serodiagnosis marker for hepatocellular carcinoma (HCC) is always a must for many reasons:

Serodiagnosis is generally non-invasive and safe technique to have a human sample.
Different radiological modalities, although its accuracy is progressing, but many times its result is misinterpreted.
The current extensively used seromarker, alpha fetoprotein (AFP), doesn’t exceed 70% for sensitivity and 90% for specificity.
Many of clinicians requesting AFP tests, whether in HCC management or related diseases, as, hepatitis C or B infections don’t know exactly the diagnostic accuracy levels of AFP.
The need for spectrophotometric marker, rather than molecular or radio or Elisa parameter as a cost effective goal.
The earlier the detection of HCC, the longer the patient life.
Septoplasty with Nasal Packing or Transseptal Suturing: comparative study
Authors: Zidan Khalaf Usama , Darweesh Fadhil Ghadeer Raad , Abdulwahab Bahjat Mohammed 
Published: January 2023

Objective: The aim of study is to find out the better option to manage post-operative septal hematoma between the nasal packing or quilting sutures.
Methods: cross sectional comparative study of 2 groups patients, group [A]; 39 patients have septoplasty with no nasal Packing and suturing, while group [B]; 40 patients have septoplasty with nasal packing. The study has been carried out from July 2021 until February 2022 in Kirkuk General Hospital. From all patients take age, gender, pain, and bleeding occurrence after few moments after surgery, then after 1st day and then after seventh day after operation. Also, if patients have synechiae or not.
Results: there is significant difference between group A and group B in bleeding at time of operation, group A patient more bleeding. There is significant difference between group A and group B in bleeding at 1st day after operation, group A patient less bleeding. There is significant difference between group A and group B in pain at 1st day after operation, group A patient less bleeding. There is significant difference between group A and group B in pain at 7th day after operation, group A patient less bleeding.
Conclusion: Nasal pain, headache, were reduced in the trans – septal suturing group as compared to packing. However, nasal bleeding was present in both the groups. It also proves to be a cost-effective modality and gives a better post-operative quality of life to patients. Hence, we recommend trans-septal suturing as the preferred method over anterior nasal packing in patients after septoplasty.
Platelet rich plasma and exercise for pain relief in end stage knee osteoarthritis
Authors: Ahmed Mohammad Abdullah , Ghali Wadi Algawwam Hayder , Ihsan KhairuAllah Huda , Abdulwahab Muhammed Ali Nuha , Abbas Ali Safwat 
Published: January 2023

Objective: To evaluate the efficacy of exercise and intra-articular ozonized platelet rich plasma (IA-OPRP) injections as management for sever grad IV knee osteoarthritis (KOA).
Methods: Over 18-month period (January 1, 2018– July 31, 2019), 33 patients (21 females and 12 males) with 58 grade IV osteoarthritic knees were retrospectively studied. Severity of KOA was assessed according to the clinical features and Kellgren &Lawrencegrading scale. All patients underwent 8-weeks simple exercises followed by 4 sessions of IA-OPRP.OPRP was prepared by centrifuging patients’ own blood and activated by passing 1 ml of ozone for each 1 ml of platelet rich plasma. A questionnaire was used to categorize the pain severity into mild, moderate, and severe and the response to therapy was graded as excellent, good, fair, and poor.
Results: The mean age was 63.7 years. The top co-morbid condition were overweight and obesity (n=28, 84.8%) whereas diabetes and hypertension ranked second (n=15 each, 45.4%). All patients had severe pain of grad IV knee OA. Overall, exercise and four IA-OPRP injections yielded good-excellent results in (72.4%) of the treated joints (p˂0.01) with no significant sex-related difference in pain response (p>0.01).
Conclusion: Exercise and IA-OPRP seems to be a safe, effective and cheap method for relieving the chronic pain of severeknee OA.
¿Rumor o verdad? La “peste” en Cartagena de Indias en 1696
Authors: Sánchez Torres Lireida José 
Published: January 2023

El presente artículo analiza una supuesta “peste” que tuvo lugar en Cartagena en 1696, a partir de un expediente que da cuenta del suceso y la conmoción que causó en ese puerto y en la capital del virreinato. Si bien no existe consenso sobre el tipo de enfermedad y el impacto mortal que tuvo en la sociedad cartagenera, este trabajo indaga acerca de varias posibilidades y se presenta como una incipiente veta de análisis para futuras investigaciones. En este sentido, el trabajo plantea aportes sobre el estudio de las epidemias en el virreinato de la Nueva Granada, específicamente en Cartagena de Indias, algunas de las cuales no s e encuentran bien documentadas o estudiadas por la historiografía. Asimismo, por medio de los testimonios de la época, se intenta adentrarse en el rol que desempeñaban el rumor y el miedo en estas situaciones, a la vez que se rastrean las rutas de contagio entre Cartagena y Santafé.
Rural Residence is Associated with a Delayed Trend Away From Sulfonylurea Use for Treatment Intensification of Type 2 Diabetes
Authors: Nagy Danielle K , C. Bresee Lauren , Eurich Dean T. , Simpson Scott H. 
Published: January 2023

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<p>Objective: To examine the intersection between location of residence along the rural-urban continuum (metropolitan/urban/rural) and sulfonylurea dispensation records for the management of type 2 diabetes.<br>
Research Design and Methods: This retrospective cohort study used administrative health records of adult new metformin users between April 2008-March 2019 in Alberta, Canada. Multivariable logistic regression was performed to examine the association between sulfonylurea-based treatment intensification and location of residence.<br>
Results: Treatment was intensified in 66,084 (38%) of 171,759 new metformin users after a mean of 1.5 years. At treatment intensification, mean age was 55 years, 62% were male, and 27% were rural residents. The most common antihyperglycemic drug, given to 30,297 (46%) people for treatment intensification, was a sulfonylurea. At the beginning of our observation period, the proportion of people dispensed a sulfonylurea at first treatment intensification was highest in rural (57%), compared to urban (54%) and metropolitan (52%) areas (p=0.009). Although proportions decreased over time across the province, rural residents continued to have the highest proportion of sulfonylurea users (45%) compared to urban (35%) and metropolitan (37%) (p< 0.001) and the trend away from sulfonylurea use was delayed by ~4 years for rural residents. Adjusting for potential sources of confounding, rural residence was associated with a significantly higher likelihood of using a sulfonylurea compared to metropolitan (aOR:1.34; 95% CI:1.29-1.39).<br>
Conclusions: Variation in sulfonylurea dispensation across the rural-urban continuum provides a basis for continued research in the differences in process of care by location.</p>