bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Efficient Self‐Assembly of Metallacages and Their Supramolecular Catalysis Behaviors in Microdroplets
Authors: Lin Hong‐Yu , Zhou Le‐Yong , Mei Fang , Dou Wei‐Tao , Hu Lianrui , Yang Hai‐Bo , Xu Lin 
Published: March 2023

AbstractDeveloping a new strategy to improve the self‐assembly efficiency of functional assemblies in a confined space and construct hybrid functional materials is a significant and fascinating endeavor. Herein, we present a highly efficient strategy for achieving the supramolecular self‐assembly of well‐defined metallacages in microdroplets through continuous‐flow microfluidic devices. The high efficiency and versatility of this approach are demonstrated by the generation of five representative metallacages in different solvents containing water, DMF, acetonitrile, and methanol in a few minutes with nearly quantitative yields, in contrast to the yields obtained with the hour‐scale reaction time in a batch reactor. A ring‐opening catalytic reaction of the metallacages was selected as a model reaction for exploring supramolecular catalysis in microdroplets, whereby the catalytic yield was enhanced by 2.22‐fold compared to that of the same reaction in the batch reactor. This work illustrates a new promising approach for the self‐assembly of supramolecular systems.
Sulfonium Salts as Acceptors in Electron Donor‐Acceptor Complexes
Authors: van Dalsen Leendert , Brown Rachel E. , Rossi‐Ashton James A. , Procter David J. 
Published: March 2023

AbstractThe photoactivation of electron donor‐acceptor complexes has emerged as a sustainable, selective and versatile strategy for the generation of radical species. Electron donor‐acceptor (EDA) complexation, however, imposes electronic constraints on the donor and acceptor components and this can limit the range of radicals that can be generated using the approach. New EDA complexation strategies exploiting sulfonium salts allow radicals to be generated from native functionality. For example, aryl sulfonium salts, formed by the activation of arenes, can serve as the acceptor components in EDA complexes due to their electron‐deficient nature. This “sulfonium tag” approach relaxes the electronic constraints on the parent substrate and dramatically expands the range of radicals that can be generated using EDA complexation. In this review, these new applications of sulfonium salts will be introduced and the areas of chemical space rendered accessible through this innovation will be highlighted.
Synthesis of Bicyclo[1.1.1]pentane (BCP)‐Based Straight‐Shaped Diphosphine Ligands**
Authors: Takano Hideaki , Katsuyama Hitomi , Hayashi Hiroki , Harukawa Miyu , Tsurui Makoto , Shoji Sunao , Hasegawa Yasuchika , Maeda Satoshi , Mita Tsuyoshi 
Published: March 2023

Abstract[1.1.1]Propellane, which is structurally simple and compact, exhibits promising potential for the synthesis of disubstituted straight‐shaped bicyclo[1.1.1]pentane (BCP) compounds by manipulation of its highly reactive internal C−C bond. BCPs are considered to be isosteres of 1,4‐disubstituted benzenes, which have found broad applications in the areas of functional molecules and drug discovery. The internal C−C single bond of [1.1.1]propellane is regarded as a charge‐shift bond, which can be readily cleaved by radical means to construct BCPs. We herein report a novel synthetic method for (un)symmetric diphosphines based on the BCP motif, which can be interpreted as isosteres of 1,4‐bis(diphenylphosphino)benzenes. The obtained BCP‐diphosphine derivatives were used to generate a straight‐shaped Au complex and an Eu‐based coordination polymer.
Dual‐Atom Support Boosts Nickel‐Catalyzed Urea Electrooxidation
Authors: Zheng Xiaobo , Yang Jiarui , Li Peng , Jiang Zhuoli , Zhu Peng , Wang Qishun , Wu Jiabin , Zhang Erhuan , Sun Wenping , Dou Shixue , Wang Dingsheng , Li Yadong 
Published: March 2023

AbstractNickel‐based catalysts have been regarded as one of the most promising electrocatalysts for urea oxidation reaction (UOR), however, their activity is largely limited by the inevitable self‐oxidation reaction of Ni species (NSOR) during the UOR. Here, we proposed an interface chemistry modulation strategy to trigger the occurrence of UOR before the NSOR via constructing a 2D/2D heterostructure that consists of ultrathin NiO anchored Ru−Co dual‐atom support (Ru‐Co DAS/NiO). Operando spectroscopic characterizations confirm this unique triggering mechanism on the surface of Ru‐Co DAS/NiO. Consequently, the fabricated catalyst exhibits outstanding UOR activity with a low potential of 1.288 V at 10 mA cm−2 and remarkable long‐term durability for more than 330 h operation. DFT calculations and spectroscopic characterizations demonstrate that the favorable electronic structure induced by this unique heterointerface endows the catalyst energetically more favorable for the UOR than the NSOR.
Iron‐Catalyzed Biomimetic Dimerization of Tryptophan‐Containing Peptides
Authors: Ueda Hirofumi , Sato Soichiro , Noda Kenta , Hakamata Hiroyuki , Kwon Eunsang , Kobayashi Nagao , Tokuyama Hidetoshi 
Published: March 2023

AbstractBiomimetic oxidative dimerization of tryptophan derivatives in aqueous media with oxygen as a bulk oxidant catalyzed by an iron octacarboxy phthalocyanine complex was established. The discovery of the extremely active iron catalyst enables aerobic enzyme‐mimetic oxidation to be performed in a flask. This method was applicable to the oxidative dimerization of a wide range of tryptophan derivatives, including various dipeptides and oligopeptides, with remarkable functional‐group tolerance without the protection of the amino acid residues. Furthermore, oxidative dimerization of tryptophan derivatives bearing dioxopiperazine units enabled the convergent total synthesis of five natural pyrroloindole compounds and unnatural congeners. The established chemical method provides facile access to a broad range of dimerized peptides with a unique scaffold to link two turn structures, which will serve as a powerful tool to create new small‐ and medium‐sized‐molecules as drug candidates.
Optical Analogs of Rabi Splitting in Integrated Waveguide‐Coupled Resonators
Authors: Arianfard Hamed , Wu Jiayang , Juodkazis Saulius , Moss David J. 
Published: March 2023

AbstractRealizing optical analogs of quantum phenomena in atomic, molecular, or condensed matter physics has underpinned a range of photonic technologies. Rabi splitting is a quantum phenomenon induced by a strong interaction between two quantum states, and its optical analogs are of fundamental importance for the manipulation of light–matter interactions with wide applications in optoelectronics and nonlinear optics. Here, purely optical analogs of Rabi splitting in integrated waveguide‐coupled resonators formed by two Sagnac interferometers are proposed and theoretically investigated. By tailoring the coherent mode interference, the spectral response of the devices is engineered to achieve optical analogs of Rabi splitting with anti‐crossing behavior in the resonances. Transitions between the Lorentzian, Fano, and Rabi splitting spectral lineshapes are achieved by simply changing the phase shift along the waveguide connecting the two Sagnac interferometers, revealing interesting physical insights about the evolution of different optical analogs of quantum phenomena. The impact of the device's structural parameters is also analyzed to facilitate device design and optimization. These results suggest a new way for realizing optical analogs of Rabi splitting based on integrated waveguide‐coupled resonators, paving the way for many potential applications that manipulate light–matter interactions in the strong coupling regime.
Gross anatomy of the Pacific hagfish, Eptatretus burgeri, with special reference to the coelomic viscera
Authors: Muramatsu Banri , Suzuki Daichi G. , Suzuki Masakazu , Higashiyama Hiroki 
Published: March 2023

AbstractHagfish (Myxinoidea) are a deep‐sea taxon of cyclostomes, the extant jawless vertebrates. Many researchers have examined the anatomy and embryology of hagfish to shed light on the early evolution of vertebrates; however, the diversity within hagfish is often overlooked. Hagfish have three lineages, Myxininae, Eptatretinae, and Rubicundinae. Usually, textbook illustrations of hagfish anatomy reflect the morphology of the Myxininae lineage, especially Myxine glutinosa, with its single pair of external branchial pores. Here, we instead report the gross anatomy of an Eptatretinae, Eptatretus burgeri, which has six pairs of branchial pores, especially focusing on the coelomic organs. Dissections were performed on fixed and unfixed specimens to provide a guide for those doing organ‐ or tissue‐specific molecular experiments. Our dissections revealed that the ventral aorta is Y‐branched in E. burgeri, which differs from the unbranched morphology of Myxine. Otherwise, there were no differences in the morphology of the lingual apparatus or heart in the pharyngeal domain. The thyroid follicles were scattered around the ventral aorta, as has been reported for adult lampreys. The hepatobiliary system more closely resembled those of jawed vertebrates than those of adult lampreys, with the liver having two lobes and a bile duct connecting the gallbladder to each lobe. Overall, the visceral morphology of E. burgeri does not differ significantly from that of the known Myxine at the level of gross anatomy, although the branchial morphology is phylogenetically ancestral compared to Myxine.
Achieving distributed consensus for networked uncertain Euler–Lagrange systems with average dwell time approach
Authors: Liu Lixia , Liu Wencheng , Li Yanping , Liu Shang , Guo Rongwei , Li Bin 
Published: March 2023

AbstractThis paper proposes a novel distributed consensus achieving algorithm for switched networked Lagrange systems with uncertain parameters, in order to solve the abruptly occurrence problem of parameters changing and communication topologies switching. We first model the multirobot systems as switched networked Lagrange systems. Then, by introducing the network topology into the sliding mode vector, a unified distributed consensus tracking strategy is then proposed by systematically combining the average dwell time (ADT) approach and adaptive control method. Besides, a sufficient condition regarding the ADT among subsystems is derived to ensure the asymptotical consensus performance of the multirobot systems. A unified analysis methodology is developed to perform the convergence analysis for the closed‐loop system by Lyapunov stable theory. Finally, illustrative examples and simulations are provided to demonstrate and validate the theoretical results.
Curcumin‐based nanoformulations alleviate wounds and related disorders: A comprehensive review
Authors: Ansari Legha , Mashayekhi‐Sardoo Habibeh , Baradaran Rahimi Vafa , Yahyazadeh Roghayeh , Ghayour‐Mobarhan Majid , Askari Vahid Reza 
Published: March 2023

AbstractDespite numerous advantages, curcumin's (CUR) low solubility and low bioavailability limit its employment as a free drug. CUR‐incorporated nanoformulation enhances the bioavailability and angiogenesis, collagen deposition, fibroblast proliferation, reepithelization, collagen synthesis, neovascularization, and granulation tissue formation in different wounds. Designing nanoformulations with controlled‐release properties ensure the presence of CUR in the defective area during treatment. Different nanoformulations encompassing nanofibers, nanoparticles (NPs), nanospray, nanoemulsion, nanosuspension, nanoliposome, nanovesicle, and nanomicelle were described in the present study comprehensively. Moreover, for some other systems which contain nano‐CUR or CUR nanoformulations, including some nanofibers, films, composites, scaffolds, gel, and hydrogels seems the CUR‐loaded NPs incorporation has better control of the sustained release, and thereby, the presence of CUR until the final stages of wound healing is more possible. Incorporating CUR‐loaded chitosan NPs into nanofiber increased the release time, while 80% of CUR was released during 240 h (10 days). Therefore, this system can guarantee the presence of CUR during the entire healing period. Furthermore, porous structures such as sponges, aerogels, some hydrogels, and scaffolds disclosed promising performance. These architectures with interconnected pores can mimic the native extracellular matrix, thereby facilitating attachment and infiltration of cells at the wound site, besides maintaining a free flow of nutrients and oxygen within the three‐dimensional structure essential for rapid and proper wound healing, as well as enhancing mechanical strength.
Synthesis and Evaluation of Piperazine‐Tethered Derivatives of Alepterolic Acid as Anticancer Agents
Authors: Liu Zi , Xia Chenlu , Wang Nina , Cao Jianguo , Huang Guozheng , Ma Liang 
Published: March 2023

AbstractAlepterolic acid is a natural diterpenoid isolated from Aleuritopteris argentea with potential anti‐cancer activity. In this study, alepterolic acid was modified to construct a series of arylformyl piperazinyl derivatives (3a–3p). The synthesized derivatives were fully characterized with HRMS, NMR, and IR. Four compounds with inhibition rate higher than 30 % at 10 μM (3f, 3n, 3g and 3k) were further measured to obtain the IC50 values against four cancer cell lines, including hepatoma cell lines HepG2, lung cancer cell lines A549, estrogen receptor‐positive cell lines MCF7, and triple‐negative breast cancer (TNBC) cell lines MDA‐MB‐231 by MTT assay. It was found that these compounds were more effective to HepG2 and MDA‐MB‐231 cells, while less toxic to A549 and MCF7 cells, and compound 3n as the most toxic derivatve against MDA‐MB‐231 cell lines, with IC50 value of 5.55±0.56 μM. Trypan blue staining and colony formation assay showed that compound 3n inhibited the growth of MDA‐MB‐231 cells and prevented colony formation. Hoechst staining, flow cytometry and western blot analysis revealed that compound 3n induced caspase‐dependent apoptosis in MDA‐MB‐231 cells. Conclusively, compound 3n was demonstrated to be a potential anti‐cancer lead compound for further investigation.
An uncommon paratubal cyst: Serous borderline tumor
Authors: Limaiem Faten , Halouani Ahmed 
Published: March 2023

AbstractParatubal cysts are almost always benign, with rare reports of paratubal serous borderline tumors (PSBT). Only 10 cases of PSBT have been reported in the literature. Their treatment in young patients relies on fertility‐preserving surgery. Herein, the authors report a case of PSBT revealed by chronic pelvic pain.
Application of wearable devices for monitoring cardiometabolic dysfunction under the exposome paradigm
Authors: Zhang Haodong , Hu Lingming , Zheng Pai , Jia Guang 
Published: March 2023

AbstractEnvironmental factors, including chemical/physical pollutants, as well as lifestyle and psychological factors, contribute greatly to the pathways leading to cardiometabolic diseases with a heavy disease burden and economic loss. The concept of exposomes provides a novel paradigm for combining all exposure characteristics to evaluate disease risk. A solution‐like exposome requires technological support to provide continuous data to monitor vital signs and detect abnormal fluctuations. Wearable devices allow people to conveniently monitor signals during their daily routines. These new technologies empower users to more actively prevent and manage cardiometabolic disease by reviewing risk factors of the disease, especially lifestyle factors, such as sleeping time, screen time, and mental health condition. Devices with multiple sensors can monitor electrocardiography data, oxygen saturation, intraocular pressure, respiratory rate, and heart rate to enhance the exposome study and provide precise suggestions for disease prevention and management.
Electrooxidation of the Glycerol Derivative Solketal over Cu−Co Hydroxycarbonates to Enable the Synthesis of Glyceric Acid
Authors: Kumari Bhawana , Braun Michael , Cychy Steffen , Sanjuán Ignacio , Behrendt Gereon , Behrens Malte , Muhler Martin , Andronescu Corina 
Published: March 2023

AbstractThe glycerol oxidation reaction (GOR) has high potential in substituting the oxygen evolution reaction (OER) in electrochemical water splitting, enabling the synthesis of value‐added organic products. The Cu‐rich Cu−Co hydroxycarbonates show high activity in GOR and promote formate production but undergo severe Cu leaching in the presence of deprotonated glycerol. In this work, the electrooxidation of solketal (SOR), acetal‐protected glycerol, is explored over a series of Cu−Co hydroxycarbonates, to promote the formation of glycerol‐derived C3 products, such as glyceric acid, with faradaic efficiencies of around 70 %, and to limit the Cu leaching from the catalyst. The competition between OER and SOR was evaluated using rotating disk electrodes and differential electrochemical mass spectrometry. Insights into the solketal de‐acetalization as a function of potential are obtained using in situ spectroscopic methods. The solketal/OH− ratio influences the reaction selectivity, with oxalate production increasing when 7 m KOH is used instead of 1 m KOH.
Lightweight diamond/Cu interface tuning for outstanding heat conduction
Authors: Dou Wenjie , Zhu Congxu , Wu Xiwang , Yang Xun , Fa Wenjun , Zhang Yange , Tong Junfeng , Zhu Guangshan , Zheng Zhi 
Published: March 2023

AbstractWith rapid developments in the field of very large‐scale integrated circuits, heat dissipation has emerged as a significant factor that restricts the high‐density integration of chips. Due to their high thermal conductivity and low thermal expansion coefficient, diamond/Cu composites have attracted considerable attention as a promising thermal management material. In this study, a surface tungsten carbide gradient layer coating of diamond particles has been realized using comprehensive magnetron sputtering technology and a heat treatment process. Diamond/Cu composites were prepared using high‐temperature and high‐pressure technology. The results show that, by adjusting the heat treatment process, tungsten carbide and di‐tungsten carbide are generated by an in situ reaction at the tungsten–diamond interface, and W–WC–W2C gradient layer‐coated diamond particles were obtained. The diamond/Cu composites were sintered by high‐temperature and high‐pressure technology, and the density of surface‐modified diamond/Cu composites was less than 4 g cm−3. The W–WC–W2C@diamond/Cu composites have a thermal diffusivity as high as 331 mm2 s−1, and their thermal expansion coefficient is as low as 1.76 × 10−6 K−1. The interface coherent structure of the gradient layer‐coated diamond/copper composite can effectively improve the interface heat transport efficiency.
Agronomic and structural responses of stockpiled alfalfa–bermudagrass mixtures
Authors: Vasco A. C. C. M. , Silva L. S. , Burt J. C. , Mason K. , Mullenix M. K. , Prevatt C. , Tucker J. J. 
Published: March 2023

AbstractThe incorporation of alfalfa (Medicago sativa L.) into bermudagrass [Cynodon dactylon (L.) Pers.] forage systems in the southern United States has increased. Stockpiling this mixture may extend the grazing season into the fall and winter months with high‐quality forage. The objective of this 2‐year study was to evaluate agronomic and structural responses of alfalfa–bermudagrass mixtures managed under five stockpiling periods (6, 8, 10, 12, or 14 weeks) in two locations (Shorter, AL, and Tifton, GA). Across locations, stockpiling mixtures for 8 weeks or longer (2400 lb DM ac−1, on average) resulted in greater (P = 0.001) herbage accumulation than 6 weeks (3185 lb DM ac−1). The alfalfa proportion was similar among stockpiling periods in Shorter but greater (P = 0.043) at 10 and 14 weeks than 6, 8, and 12 weeks in Tifton. A location × year × stockpiling interaction was observed for crude protein (CP, P < 0.001) and in vitro true dry matter digestibility over 48 h (IVTDMD48, P < 0.001). Crude protein concentrations were similar among stockpiling periods in 2020 in both locations. In 2019, however, CP concentrations reduced with increasing stockpiling period length in Shorter and were similar among treatments in Tifton, except for the lesser CP at 8 than at 10, 12, and 14, weeks. Forage IVTDMD48 concentrations declined with increasing stockpiling period length at both locations, with a more pronounced decline in Shorter in 2019. Results suggest that stockpiling alfalfa–bermudagrass mixtures for up to 8 weeks is a viable option to supply high nutritive value forage and lower lodging losses into the early winter months.
A concise review on recent advances in catalytic asymmetric hydrogenation
Authors: Behera Priyanka , Ramakrishna Duggirala S. , Chandrasekhar Manchikanti M. , Kothakapu Sridhar Reddy 
Published: March 2023

AbstractAccounts on the recent (over the past 10 years) catalytic asymmetric hydrogenation reaction‐based achievements with different catalysts to generate natural products and synthetic targets such as fragrances, pharmaceutical agents, and agrochemicals are mentioned in this present concise review. Mechanistic steps, chemoselectivity with higher functional group tolerance by employing transition metal‐based chiral catalysts (Ir‐, Rh‐, Ni‐, Ru‐, Fe‐, Mn‐, Pd‐, Co‐, and Zn‐based organometallic chiral complexes), and biocatalysts and their importance on the genesis of chirality coupled with higher turnover numbers are also described.
Targeting lysosomal HSP70 induces acid sphingomyelinase‐mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies
Authors: Qing Yingjie , Guo Yongjian , Zhao Qinwen , Hu Po , Li Hui , Yu Xiaoxuan , Zhu Mengyuan , Wang Hongzheng , Wang Zhanyu , Xu Jingyan , Guo Qinglong , Hui Hui 
Published: March 2023

AbstractBackgroundT cell malignancies proliferate vigorously, are highly dependent on lysosomal function, with limited therapeutic options. Deregulation of lysosomal structure and function has been confirmed to be a key role in the treatment of hematologic malignant disease.MethodsCell counting kit 8 and Annexin V/PI staining were used to assess the cell viability and apoptosis rate. Flow cytometry, liquid chromatography mass spectrometry, immunofluorescence and western blot were performed to detect the effect on lysosomes. Drug affinity responsive target stability, molecular docking and cellular thermal shift assay were employed to confirm the target protein of V8 on lysosomes. A xenograft model was constructed inNOD/SCIDmice to assess the effect and mechanism.ResultsV8, a new lysosomotropic compound, could be rapidly trapped by lysosomes and accumulation in lysosomes, contributing to lysosomal‐dependent cell death by evoking lysosomal membrane permeabilization (LMP), accompanied with disrupted lysosome and autophagic flux. Mechanistically, heat shock protein 70 (HSP70) was identified as the binding target of V8 in lysosome. As a downstream effect of targeting HSP70, enzymatic activity of acid sphingomyelinase (ASM) was inhibited, which induced disturbance of lipid metabolism, instability of lysosomal membrane, and leakage of cathepsin B and D, leading to LMP‐mediated cell death. In vivo study showed V8 well controlled the growth of the tumour and confirmed lysosomal cell death induced by V8.ConclusionsCollectively, this study suggests targeting lysosomal HSP70‐ASM axis by V8 illustrates the great value of drug therapy for T cell malignancies and the unlimited potential of lysosomal targeting for cancer therapy.