bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthonomus grandis grandis Boheman (Coleoptera: Curculionidae) induces the formation of shelter structures in cotton plants
Authors: Vale Willian Santos do , Neto Benicio de Melo Santos , Araújo Lilian Rocha , Santana Henrique Juan Cardoso , Silva Thainara Ferreira Germano da , Bastos Cristina Schetino , Silva Carlos Alberto Domingues da , Zanuncio José Cola , Leite Suzany Aguiar , Castellani Maria Aparecida 
Published: May 2023

Abstract

Background
Herbivorous arthropods induce their hosts to form plant structures where they shelter during unfavorable periods. The boll weevil Anthonomus grandis grandis (Coleoptera: Curculionidae) can spend the off-season inside cotton plant structures, known as dry boll, protected from pesticides, natural enemies, and the heat and desiccation of the soil surface, increasing its survival and preserving its reproductive capacity. However, the relationship between the boll weevil and dry boll formation requires further study. The formation and external and internal characteristics of dry boll in cotton plants infested by boll weevils and the emergence and survival of this insect in these structures during infestation were evaluated.
Results
Plants infested by boll weevil formed almost twice as many dry bolls, which were 2.3 times heavier and with a diameter 1.7 times larger than those formed by non-infested plants.
Conclusion
Weevils induce the formation of structures in cotton plants to increase their survival during the crop off-season.
Biomonitoring of Heavy Metals Pollution in the University of Lagos, Akoka Campus Environment using the Moss Mnium Hornum Hedw
Authors: Igbari Aramide Dolapo , Amusa Oluwafemi Daniel , Orisejobor Divine Favour , Ogundipe Oluwatoyin Temitayo 
Published: May 2023

Abstract

This study investigated the deposition of heavy metals pollution in the University of Lagos, Akoka campus using the moss (Mnium hornum Hedw.) as a bioindicator. Samples of M. hornum. were collected in 2019 from four different locations within the University of Lagos campus: Faculty of Engineering (FE), Lagoon Front (LF), Main Library (ML) and Akintunde Ojo Library (AKT). A control sampling was done at First Estate, Amuwo-Odofin LGA (CL). The concentrations of Cadmium (Cd), Cobalt (Co), Chromium (Cr), Copper (Cu), Iron (Fe), Manganese (Mn), Nickel (Ni), Lead (Pb), and Zinc (Zn) were determined using the Atomic Absorption Spectrometer. Results confirmed the presence of heavy metals in this order Fe>Zn>Mn>Cu>Pb>Ni>Co>Cr>Cd. The concentrations of the examined heavy metals across the locations were lowest in CL except Ni which was lowest in FE and LF (0.03mg/kg). While there was no significant difference in the concentrations of Cd, Co, Cr, Cu, Mn, Ni, and Pb among locations, both Fe (66.00mg/kg) and Zn (64.33mg/kg) were significantly higher in ATK than in the other locations. The contamination factor suggests that ML (C2), FE (C3) and LF (C3) were moderately contaminated while AKT (C5) was seriously contaminated. The index of geo-accumulation revealed that FE (Igeo4) and ML (Igeo4) are moderate to severely polluted, LF (Igeo5) was severely polluted and AKT (Igeo7) was extremely polluted with the assayed metals. The difference in the occurrence of anthropogenic activities was seen to be the major factor responsible for the variations in the concentration of heavy metals accumulated by the mosses.
Oroxin A from Oroxylum indicum improves disordered lipid metabolism by inhibiting SREBPs in oleic acid-induced HepG2 cells and high-fat diet-fed noninsulin-resistant rats
Authors: Cai Tianqi , Xu Xiaoxue , Dong Ling , Liang Shufei , Xin Meiling , Wang Tianqi , Li Tianxing , Wang Xudong , Zheng Weilong , Wang Chao , Xu Zhengbao , Wang Meng , Song Xinhua , Li Lingru , Li Jingda , Wenlong Sun 
Published: May 2023

Abstract

Background
Lipid metabolism disorders have become a major global public health issue. Due to the complexity of these diseases, much more research and many more drugs are needed to address them. Oroxin A, the major component of Oroxylum indicum (L.) Kurz (Bignoniaceae), can improve the lipid profiles of diabetic and insulin-resistant (IR) rats. Since insulin resistance is highly correlated with lipid metabolism, improving insulin resistance may also be an effective way to improve lipid metabolism. Thus, more research on the efficacy and mechanism of oroxin A under non-IR conditions is needed.
Method
In this research, we established lipid metabolism disorder rats by high-fat diet feeding and fatty HepG2 cell lines by oleic acid induction and evaluated the therapeutic effect and mechanism of oroxin A in vitro and in vivo by biochemical indicators, pathological staining, immunoblotting, and immunofluorescence staining.
Results
Oroxin A improved disordered lipid metabolism under non-IR conditions, improved plasma and hepatic lipid profiles, and enhanced the lipid-lowering action of atorvastatin. Additionally, oroxin A reduced the total triglyceride (TG) level by inhibiting SREBP1 expression and reducing the expression of ACC and FASN in vivo and in vitro. Oroxin A also reduced the total cholesterol (TC) level by inhibiting SREBP2 expression and reducing HMGCR expression in vivo and in vitro. In addition, oroxin A bound LDLR and increased AMPK phosphorylation.
Conclusion
Our results suggested that oroxin A may modulate the nuclear transcriptional activity of SREBPs by binding to LDLR proteins and increasing AMPK phosphorylation, thereby reducing lipid synthesis for lipid metabolism disorder treatment and prevention.
Terrain influence landscape patterns of burn severity in subtropical forests of southern China
Authors: Guo Lingling , Wu Zhiwei , Parsons Russell A. , Li Shun , Xie Gu'ai 
Published: May 2023

Abstract
Context Understanding the landscape patterns of burn severity is vital for managing fire-prone ecosystems. Relatively limited research has been done about fire and burn severity patterns in subtropical forests.Methods Using Landsat 8 OLI remote sensing imagery, this paper spatially mapped the burn severity of 27 forest fires in the subtropical broadleaved evergreen forest in Southern China from 2017–2021. The landscape pattern of patches with different burn severity was quantified using landscape indices. In addition, factors influencing the patterns of burn severity across the landscape were determined using the Geodetector model.Results Burn severity of patches varied significantly. High burn severity was common in forest patches with low fragmentation, low patch density, and regular shape. In contrast, moderate and low burn severity was prevalent in patches with smaller patch size, high patch density, and complex shapes. Extensively burned forest patches were located at higher elevations, while more fragmented patches were located in gently sloping areas. Topographic factors were the most significant factors influencing variances in burn severity across the forest patches, followed by climatic conditions. A detailed understanding of burn severity patterns and driving factors in a landscape can help develop sustainable forest management and restoration strategies after severe forest fire disturbances.
Implementing a digital solution for patients with migraine - developing a methodology for comparing digitally delivered treatment to conventional treatment: A study protocol
Authors: Niiberg-Pikksööt Triinu , Laas Kariina , Aluoja Anu , Braschinsky Mark 
Published: May 2023

Abstract

Background Migraine is one of the most frequent and expensive neurological disease in the world. Non-pharmacological and digitally administered treatment options have long been used in the treatment of chronic pain and mental illness. Digital solutions increase the patients’ possibilities of receiving evidence-based treatment even when conventional treatment options are limited. The main goal of the study is to assess the efficacy of interdisciplinary digital interventions compared to conventional treatment.Methods The maximum number of participants in this multi-centre, open-label, prospective, randomised study is 600, divided into eight different treatment groups. The participants take part in either a conventional or a digital intervention, performing various tests and interdisciplinary tasks. The primary outcome is a reduction in the number of headache days. We also measure various other headache-related burdens as a secondary outcome.Discussion Based on preliminary data from the pilot study, digitally mediated treatment reduces a specialist’s time spent on a single patient by more than tenfold. The sample size; digital interventions not conducted via video calls; a lack of human connection; limited intervention programmes and conducting studies only in digitally sophisticated countries are all significant limitations. However, we believe that digitally mediated treatment options are at least as effective as traditional treatment options while also allowing for a significantly higher patient throughput. The future of chronic disease treatment is remote monitoring and high-quality digitally mediated interventions.Registration: The study is approved by the Ethics Committee of the University of Tartu for Human Research (permission no 315T-17, 10.08.2020) and is registered at ClinicalTrials.gov: NTC05458817 (14.07.2022)
Rehabilitation in Primary Health Care for the ageing population: A secondary analysis from a scoping review of rehabilitation models for the ageing population
Authors: Seijas Vanessa , Roxanne Maritz , Mishra Satish , Bernard Renaldo M , Fernandes Patricia , Lorenz Viola , Machado Barbara , Posada Ana María , Lugo Luz Helena , Bickenbach Jerome , Sabariego Carla 
Published: May 2023

Abstract
Background: The world population is ageing rapidly. Rehabilitation is one of the most effective health strategies for improving the health and functioning of older persons. An understanding of the current provision of rehabilitation services in primary health care (PHC) is needed to optimise access to rehabilitation for the ageing population. The objectives of this scoping review are a) to describe how rehabilitation services are currently offered in PHC to the ageing population, and b) to explore age-related differences in the type of rehabilitation services provided.
Methods: We conducted a secondary analysis of a scoping review examining rehabilitation models for older persons, with a focus on PHC. Medline and Embase (2015-2022) were searched to identify studies published in English on rehabilitation services for people aged 50+. Two authors independently screened records and extracted data using the World Health Organization (WHO)'s operational framework, the PHC systems (PRIMASYS) approach and the WHO paper on rehabilitation in PHC. Data synthesis included quantitative and qualitative analysis.
Results: We synthesised data from 96 studies with 31,956 participants and identified five models for rehabilitation in PHC for the ageing population: community, home, telerehabilitation, outpatient and eldercare. Nurses, physiotherapists, and occupational therapists were the most common providers, with task-shifting reported in 15.6% of studies. The most common interventions were assessment of functioning, rehabilitation coordination, therapeutic exercise, psychological interventions, and self-management education. Environmental adaptations and assistive technology were rarely reported.
Conclusions: By understanding models of rehabilitation service delivery in PHC, stakeholders can work towards developing more comprehensive and accessible services that meet the diverse needs of the ageing population, considering multimorbidity, evidence of heterogeneity in the ageing process, and the importance of using limitations in functioning as a starting point. Our findings, highlight rehabilitation's role in healthy ageing and are a valuable resource for informing policy, practice, and future research in the context of the United Nations Decade of Healthy Ageing. They can also inform WHO's ongoing efforts to strengthen PHC for the provision of rehabilitation, as recommended by the Rehab2030 initiative and reaffirmed by the recently adopted World Health Assembly (WHA) resolution on strengthening rehabilitation in health systems.
Modeling the adsorption mechanism of 3-tertiary-butyl-4-hydroxyanisole (3BHA) on polyethylene and polypropylene microplastics.
Authors: Monteiro Norberto , Machado Richele 
Published: May 2023

Abstract
The Polyethylene (PE) and polypropylene (PP) microplastics (MPs), can act as carriers of the molecule 3-tertiary-butyl-4-hydroxyanisole (3BHA), which propose harmful impacts to aqueous ecosystems. Meanwhile, 3BHA has already been detected in several environments and human urine and serum samples. 3BHA is an antioxidant in foods, food packaging, cosmetics and pharmaceuticals. However, it raised concerns about its possible endocrine-disrupting effect in recent years. The interaction between two MPs and 3BHA could start in farmland and be maintained during transportation to the ocean. Herein, the adsorption behavior and mechanism of 3BHA by PE and PP MPs were investigated via molecular dynamics (MD) simulation, density functional theory (DFT), non-covalent interactions (NCI), the density of states (DOS) and frontier molecular orbital (FMO). Furthermore, the stability of 3BHA adsorbed complexes was investigated by adsorption-free energies (ΔGads), showing that the 3BHA has a significant interaction with the MPs studied, mainly with PP MP. Intermolecular van der Waals forces were one of the primary adsorption mechanisms of 3BHA by MPs, as evidenced by NCI calculations. It was demonstrated that the adsorption of the 3BHA in MPs decreases the energy gap of the HOMO and LUMO orbitals, as well as a slight shift in the HOMO and LUMO states in the TDOS analysis. In conclusion, this study about the mechanism of adsorption of the 3BHA in PE and PP MPs can provide new evidence and enhance our understanding of the environmental behavior of 3BHA in the environment.
The accuracy of navigated imageless total hip arthroplasty compared to conventional total hip arthroplasty in respect of leg length and hip off-set restoration
Authors: Laggner Roberta , Oktarina Anastasia , Windhager Reinhard , Bostrom Mathias P. G. 
Published: May 2023

Abstract
Background
While previous studies on navigated total hip replacement (nTHA) focused on acetabular component positioning, we compared the results of nTHA with conventional total hip replacement (cTHA) in respect to leg length and hip offset restoration.
Methods
In a single-center study results radiographic parameters of patients with unilateral THA were included. Data were prospectively collected and then retrospectively analyzed from computer navigation data and radiographs. Analysis concentrated on the discrepancy in leg length (LLD) and hip offset (OSD) between the affected and unaffected hip. The restoration effect was defined as the difference between postoperative and preoperative LLD and OSD values in each group.
Results
2332 patients were analyzed. Both nTHA and cTHA were effective in restoring LLD and OSD by reducing the preoperative value significantly (p < 0.001). Regarding LLD restoration, no statistical difference between nTHA and cTHA could be found.OSD restoration nTHA was a slightly more effective than cTHA (-2.06 + 6.00 mm vs.-1.50 + 5.35 mm; p < 0.05).
Conclusion
Both navigated and conventional THA were successful in restoration of leg length and hip offset, while postoperative offset discrepancy was significantly lower in the navigated group at the cost of longer operation times. If these results are clinically relevant further investigation is needed.
Level of evidence:
III: retrospective case series study, therapeutic investigation of a treatment.
Association between patterns of nutrient intake and circulating vitamin D with sleep duration and sleep quality among Iranian adults
Authors: Rouhani Parisa , Lotfi Keyhan , Hajhashemi Zahra , Mokhtari Elahe , Heidari Zahra , Saneei Parvane 
Published: May 2023

Abstract
Background
The association between dietary nutrient patterns and sleep habits has not been investigated in adults. The purpose of this study was to examine the relationship between dietary nutrient patterns and circulating 25(OH)D concentrations with sleep duration and sleep quality among Iranian adults.
Methods
We used a multistage cluster random sampling method to enroll 535 adults in this cross-sectional investigation. A validated food frequency questionnaire was applied to evaluate typical dietary intakes. Fasting blood samples were obtained to determine levels of circulating 25(OH)D. Sleep characteristics were assessed using the Pittsburgh Sleep Quality Index (PSQI).
Results
Participants had a mean age of 42.57 years and 51.2% of them had insufficient or deficient levels of serum vitamin D. Three NPs were identified: "high animal protein", "high vegetable" and "high carbohydrate". After adjustments for potential confounders, no significant associations were observed between "high animal protein" pattern and short sleeping or sleep quality. Greater adherence to "high vegetable" NP was associated with lower odds of short sleeping (OR = 0.24; 95%CI: 0.10, 0.54) and poor sleep quality (OR = 0.45; 95%CI: 0.20, 1.05). Stratified analysis revealed that these associations were stronger in normal-weight participants. Greater adherence to "high carbohydrate" NP, on the other hand, was connected to higher odds of short sleeping (OR = 2.83; 95%CI: 1.20, 6.72). Low adherence to "high vegetable" pattern and vitamin D insufficiency/deficiency were jointly associated with increased odds of short sleeping (OR = 3.42, 95%CI: 1.42, 6.64).
Conclusion
Adults with higher adherence to the "high vegetable" NP had considerably a lower chance of being short sleepers and having poor sleep quality; these relations were stronger in normal-weight subjects. Low adherence to the "high vegetable" pattern and insufficient/deficient vitamin D levels were synergistically associated with greater likelihood of being short sleepers. Greater adherence to "high carbohydrate" NP was associated with higher odds of short sleeping.
A novel and sensitive fluorescence immunoassay on the basis of the inner-filter effects of quantum dots for the determination of norfloxacin in animal-origin foods
Authors: Hu Gaoshuang , Su Dan , Yu Qingxiu , Zhao Tao , Gao Shan , Hao Jianxiong 
Published: May 2023

Abstract
A highly sensitive and reliable fluorescence immunoassay based on the inner-filter effects (IFE) of quantum dots (QDs) was developed for the sensitive detection of norfloxacin (NOR) in animal-origin foods. Briefly, the enzymatic formation of horseradish peroxidase in conventional ELISA effectively quenched the fluorescence of QDs through IFE, and then the absorption signal of conventional ELISA was transformed to fluorescent signals, resulting in a higher sensitivity for NOR detection in animal-origin foods.The detection limit of NOR in this developed method was 0.20 µg L− 1 in standard solution, which was 12-fold more sensitive than conventional ELISA (2.50 µg L− 1). The results of specificity analysis revealed that the proposed method could not only be used for the detection of NOR, but also for the other 9 structural analogues. The recovery rates of NOR-spiked animal-origin foods ranged from 88.11–108.16%, with CV values of 1.95%-18.03%. In addition, the established method had good consistency with the commercial ELISA kits and HPLC, indicating the accuracy of the developed method for the detection of NOR in real samples. In conclusion, the established fluorescence immunoassay was sensitive and facile, and could be alternatively used for the determination of NOR residues in animal-origin foods.
A Blended Root-Finding Algorithm for Solving Transcendental Equations
Authors: Thota Srinivasarao 
Published: May 2023

Abstract
This paper focus on a new blended root-finding algorithm to solve the given transcendental equations. This algorithm is based on the classical methods, namely Newton-Raphson method and trisection method. One of the advantages of the proposed algorithm is not only fast converging but also guarantee the root. The proposed algorithm is easy to understand and one can implement this algorithm in any mathematical software tools. Several numerical examples are presented to illustrate the algorithm and comparisons are made to show the efficiency of the proposed algorithm.
2010 AMS classifications: 65N30
Depiction of Chlorophyll in Nanofiber of Polymethylmethacrylate (PMMA)
Authors: Jassim Zainab , Akraa Mohammed 
Published: May 2023

Abstract
The widespread application of poly methyl methacrylate (PMMA) attracted the exerting efforts here to investigate the ability of production Nano fibers of this polymer material enhanced by natural chlorophyll pigment. The work aimed to construct a general visualization about the allowed bound of the addition of the natural chlorophyll pigment to PMMA nanofiber by presenting a general statistical model. Different chlorophyll concentrations were added to the matrix material throughout preparing the specimens. Production of nanofibers has been concocted by using the electrospinning technique. The reliable assessment norm in this paper is the extent of compatibility of the additive concentration in the used polymer. The results of viscosity of the variant solutions, images of Scanning electronic microscope SEM, Analysis of Fourier Transformation Infrared Radiation FT-IR, demonstrated their subordination to the Gaussian distribution versus the chlorophyll concentration. The distinctive allocation revealed two asymmetric plateaus. The smaller first one represented the manner properties of the homogenous Nano fibers. However, the great plateau symbolized the behavior of the heterogeneous specimens. The gained regions determined the allowed limits of the homogeneity and heterogeneity of the Nano fibers depending on the additive chlorophyll concentration.
Cardiac AAV9:PKP2 Gene Therapy Reduces Ventricular Arrhythmias, Reverses Adverse Remodeling, and Reduces Mortality in a Mouse Model of ARVC
Authors: Wu Iris , Greer-Short Amara , Aycinena Alex , Tefera Anley , Shenwai Reva , Farshidfar Farshad , Pell Melissa Van , Xu Emma , Reid Chris , Getuiza Neshel , Lim Beatriz , Chung Tae Won , Butler Renee , Steltzer Stephanie , Ho Jaclyn , Green Kristina , Ivey Kathryn , Hoey Timothy , Yang Jin , Zeng Aliya , Yang Zhihong 
Published: May 2023

Abstract
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying genetic cause of this disease. Mutations in desmosome gene Plakophilin-2 (PKP2) account for 45% of ARVC cases and result in reduced gene expression. Our goal is to examine the feasibility and the efficacy of adeno-associated virus 9 (AAV9)-mediated restoration of PKP2 expression in a cardiac specific knock-out mouse model of Pkp2. We demonstrated that a single-dose cardiac AAV9:PKP2 gene delivery effectively prevented disease development before overt cardiomyopathy and attenuated disease progression after overt cardiomyopathy. Restoration of PKP2 expression leads to highly coordinated and durable correction of PKP2-associated transcriptional networks beyond desmosomes, revealing a broad spectrum of biological perturbances behind ARVC disease etiology. These results indicate that cardiac AAV9:PKP2 gene therapy may be a promising therapeutic approach to treat ARVC patients with PKP2 mutations.