bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel method for genomic-enabled prediction of cultivars in new environments
Authors: Montesinos-López Osval A. , Ramos-Pulido Sofia , Hernández-Suárez Carlos Moisés , Mosqueda González Brandon Alejandro , Valladares-Anguiano Felícitas Alejandra , Vitale Paolo , Montesinos-López Abelardo , Crossa José 
Published: July 2023

IntroductionGenomic selection (GS) has gained global importance due to its potential to accelerate genetic progress and improve the efficiency of breeding programs.Objectives of the researchIn this research we proposed a method to improve the prediction accuracy of tested lines in new (untested) environments.Method-1The new method trained the model with a modified response variable (a difference of response variables) that decreases the lack of a non-stationary distribution between the training and testing and improved the prediction accuracy.Comparing new and conventional methodWe compared the prediction accuracy of the conventional genomic best linear unbiased prediction (GBLUP) model (M1) including (or not) genotype × environment interaction (GE) (M1_GE; M1_NO_GE) versus the proposed method (M2) on several data sets.Results and discussionThe gain in prediction accuracy of M2, versus M1_GE, M1_NO_GE in terms of Pearson´s correlation was of at least 4.3%, while in terms of percentage of top-yielding lines captured when was selected the 10% (Best10) and 20% (Best20) of lines was at least of 19.5%, while in terms of Normalized Root Mean Squared Error (NRMSE) was of at least of 42.29%.
High-performance work practices and employee wellbeing: organizational identification as a mediator
Authors: Salin Denise , Stride Chris , Smith Sofia , Santokhie Stefan 
Published: July 2023

AimThe aim of this study was to examine how high-performance work practices affect engagement and workplace bullying, two different aspects of employee wellbeing. Furthermore, the study sought to examine the potential mediating role of organizational identification in these relationships.Method A two-wave survey study (n = 213) was conducted among psychologists in Finland.ResultsThe results showed that high-performance work practices (HPWPs) were positively associated with engagement and negatively associated with the risk of workplace bullying. Moreover, organizational identification acted as mediator of the HPWPs-engagement relationship, though alongside the significant indirect effect via organizational identification there was also a significant direct effect of HPWPs on engagement.DiscussionThe study adds knowledge to ongoing debates on whether HPWPs support or undermine employee wellbeing. In particular, it extends our understanding of the association between HPWPs and relationship wellbeing, a topic that has so far received scant attention. Furthermore, the study advances our understanding of explanatory mechanisms in the HPWPs-engagement relationship and points to the importance of organizational identification for explaining why HPWPs lead to higher engagement.
Short-term effect of household indebtedness and risk of alcohol use disorder among Korean youth: 2017–2020 longitudinal panel study
Authors: Kim Jinhyun , Yun Il , Kim Hyunkyu , Park Eun-Cheol 
Published: July 2023

BackgroundIn Republic of Korea, household debt has increased recently among young adults, especially during the COVID-19 pandemic. Household debt may potentially lead to numerous outcomes including alcohol use disorder (AUD). The aim of this study was to investigate the relationship between a change in indebtedness and the risk of developing AUD.MethodsA total of 5,091 participants (2,720 men and 2,371 women) were included during a 4-year study period. Indebtedness was divided into four groups: no debt a year ago and at present (group 1), paying off a year’s debt (group 2), newly incurred current debt after a year when there was no debt (group 3), and indebtedness a year ago and at present (group 4). Groups 2, 3, and 4 were also divided into subgroups based on debt characteristics. AUD risk was evaluated by the CAGE scale, and a score of 2 or higher was defined as AUD high risk. Several time-varying socioeconomic and health-related characteristics were adjusted.ResultsParticipants who indicated indebtedness at present (groups 3 and 4) were more likely to be AUD high-risk compared to group 1 in both genders (men: adjusted relative risk [aRR] = 1.031, 95% CI [1.014–1.049] in group 3, aRR = 1.028, 95% CI [1.007–1.050] in group 4; women: aRR = 1.039, 95% CI [1.016–1.163] in group 3, aRR = 1.028, 95% CI [1.007–1.050] in group 4). Even paid-off debt affected the risk of AUD among female participants (aRR = 1.018, 95% CI [1.001–1.034] in group 2). Women whose amount of debt increased for 1 year were more likely to be AUD high-risk compared to group 1. Women showed higher aRR than men for increasing CAGE scores by one unit in all debt subgroups.ConclusionOur research demonstrated a possible link between indebtedness and a heightened risk of AUD. These results underscore the importance of implementing targeted screening and interventions for AUD, particularly among young women who are facing mounting levels of debt.
Case report for an internet- and mobile-based intervention for internet use disorder
Authors: Bernstein Karina , Zarski Anna-Carlotta , Pekarek Emilia , Schaub Michael Patrick , Berking Matthias , Baumeister Harald , Ebert David Daniel 
Published: July 2023

Background and aimsInternet use disorder (IUD), characterized as the inability to control one’s internet use, is associated with reduced quality of life and mental health comorbidities such as depression, substance abuse, or anxiety. Evidence-based treatment options are scarce due to the novelty of the diagnosis. Internet- and mobile-based interventions (IMI) may be an effective means to deliver psychological treatment to individuals with IUD as they address affected individuals in their online setting. This study presents a newly developed IMI for IUD disclosing treatment satisfaction and preliminary effects by exemplifying with a case report.MethodsThe case of a female participant with IUD, characterized by an excessive use of social media, is analyzed. The case report follows the CARE guidelines and presents qualitative and quantitative outcomes regarding potential symptom reduction measured by the Internet Addiction Test (IAT) and Compulsive Internet Use Scale (CIUS), treatment satisfaction measured by the Client Satisfaction Questionnaire (CSQ) and feasibility by analyzing participant’s written feedback during treatment.ResultsThe case report shows that internet- and mobile-based interventions may be feasible in supporting an individual in reducing symptoms of IUD as well as depressive symptoms, anxiety and procrastination behavior. Treatment satisfaction was reported as good.Discussion and conclusionsThis case report illustrates that IMIs can have the potential to be an easily accessible and possibly effective treatment option for IUD. Case studies on IMIs may provide insights into important mechanisms for symptom change. Further studies are needed to expand our understanding of this diverse disorder to provide adequate treatment.Clinical Trial Registrationhttps://clinicaltrials.gov/,DRKS00015314.
Association of monetary diet cost of foods and diet quality in Spanish older adults
Authors: Bouzas Cristina , Pastor Rosario , García Silvia , Monserrat-Mesquida Margalida , Martínez-González Miguel Ángel , Salas-Salvadó Jordi , Corella Dolores , Schröder Helmut , Martínez J. Alfredo , Alonso-Gómez Ángel M. , Wärnberg Julia , Vioque Jesús , Romaguera Dora , Lopez-Miranda José , Estruch Ramon , Tinahones Francisco J. , Lapetra José , Serra-Majem Lluís , Riquelme-Gallego Blanca , Romero-Secin Anny , Pintó Xavier , Gaforio José J. , Matía Pilar , Vidal Josep , Zapatero Miriam , Daimiel Lidia , Ros Emilio , García-Arellano Ana , Babio Nancy , Gonzalez-Monje Inmaculada , Castañer Olga , Abete Itziar , Tojal-Sierra Lucas , Benavente-Marín Juan Carlos , Signes-Pastor Antonio , Konieczna Jadwiga , García-Ríos Antonio , Castro-Barquero Sara , Fernández-García José C. , Santos-Lozano José Manuel , Bes-Rastrollo Maira , Mestres Cristina , Guillem-Saiz Patricia , Goday Albert , Goicolea-Güemez Leire , Puig-Aguiló Estanislao , Ruiz-Canela Miguel , Palau-Galindo Antoni , Fitó Montse , Tur Josep A. 
Published: July 2023

BackgroundA major barrier to a healthy diet may be the higher price of healthy foods compared to low-quality foods.ObjectivesThis study aimed to assess the association between the monetary cost of food and diet quality in Spanish older adults at high risk of cardiovascular disease.MethodsCross-sectional analysis was carried out in Spanish older adults (n= 6,838; 48.6% female). A validated food frequency questionnaire was used to assess dietary intake. Metabolic syndrome severity, adherence to the Mediterranean diet (MedDiet), adherence to a provegetarian dietary pattern, and dietary inflammatory index were assessed. The economic cost of the foods was obtained from the Spanish Ministry of Agriculture Fisheries and Food database (2015–2017, the period of time when the participants were recruited). The total cost of diet adjusted per 1,000 kcal was computed.ResultsThe healthier dietary pattern was associated with a higher cost of the diet. Higher adherence to the MedDiet, anti-inflammatory diet, and the healthy version of the provegetarian dietary pattern were related to higher costs of the diet.ConclusionHigher diet quality was associated with a higher dietary cost of the diet per 1,000 kcal/day. Food prices can be an important component of interventions and policies aimed at improving people's diets and preventing diet-related chronic diseases.Clinical trial registry numberThe trial was registered in 2014 at the International Standard Randomized Controlled Trial (ISRCT;http://www.isrctn.com/ISRCTN89898870) with the number 89898870.
“We can tell a good teacher who cares, understands, and can be confidential about it”: youth and caregiver experiences with HIV disclosure to schools in Kenya
Authors: Moraa Hellen , Njuguna Irene , Mugo Cyrus , Mbwayo Anne , Nyapara Florence , Aballa Calvins , Wagner Anjuli Dawn , Wamalwa Dalton , John-Stewart Grace , Inwani Irene , O'Malley Gabrielle 
Published: July 2023

IntroductionDisclosure of one's HIV status to others is often difficult due to the fear of stigma. However, disclosure may facilitate receiving social support. Many youth living with HIV (YLH) are enrolled in school as better treatments have improved the health and survival of children with HIV. There is no structured process for disclosure at school for YLH and their caregivers. We sought to understand school disclosure experiences among YLH and their caregivers and assess the need for the development of a structured disclosure intervention tailored to school settings.MethodsWe conducted in-depth qualitative interviews with 28 school-going YLH aged 14–19 years and 24 caregivers of YLH. Interviews were conducted in English and Swahili, transcribed, and translated. The transcripts were uploaded to Atlas.ti 9 for thematic analysis.ResultsYLH and caregivers clearly articulated the benefits of disclosing to school staff. Disclosure to school staff was seen as the first step to receiving support for medication storage, adherence, and clinic attendance. However, disclosure was also perceived to be a very complicated and stressful process. Fear of stigma drove caregivers and YLH toward careful planning of when and to whom to disclose. Distrust of school staff was a significant barrier to disclosure, even among those who clearly articulated the benefits of disclosure. Disclosure to school staff largely resulted in positive experiences; the immediate reactions were positive or somewhat neutral and confidentiality was upheld. The anticipated benefits of practical and emotional support were demonstrated by the school staff to whom the HIV information was disclosed.ConclusionDisclosure of HIV status to someone at school is necessary to receive support for medication adherence. Stigma and the lack of structured support for the disclosure process at school often hinder YLH and their caregivers from disclosing. YLH would benefit from better support at schools, including policies to facilitate disclosure that address the caregiver and YLH's fear of stigma and loss of confidentiality. School policies could also provide guidance on whom to disclose to and available post-disclosure support.
Gender-specific social and environmental correlates of active travel to school in four European countries: the HBSC Study
Authors: Brindley Catherina , Hamrik Zdenek , Kleszczewska Dorota , Dzielska Anna , Mazur Joanna , Haug Ellen , Kopcakova Jaroslava , Marques Adilson , Altenburg Teatske , Demetriou Yolanda , Bucksch Jens 
Published: July 2023

IntroductionDespite the health benefits, a large proportion of girls and boys in Europe do not travel to school actively. A better understanding of the correlates associated with this behavior could guide interventions. This study examines perceived social and environmental correlates of active travel to school (ACTS) from the 2017/18 Health Behavior in School-Aged Children (HBSC) survey in four European countries, with a special emphasis on gender differences (n = 22,023).MethodsLogistic regression was conducted to analyze associations between the perceived importance of each correlate and ACTS behavior for 11-, 13-, and 15-year-old girls and boys from Germany, Czechia, Poland, and Slovakia. All models were adjusted for age, family affluence, and meeting World Health Organization recommendations for moderate-to-vigorous physical activity.ResultsRates of ACTS significantly differed between girls and boys. In Czechia, 65% of girls and boys traveled to school actively, followed by Slovakia (61.4% girls and 58.4% boys), Poland (57.7% girls and 60.2% boys), and Germany (42.6% girls and 48.6% boys). Girls were less likely to actively travel to school compared to boys (odds ratio [OR]: 0.92, 95% confidence interval [CI]: 0.87–0.97). Increasing age (OR: 0.95, 95% CI: 0.93–0.97) and a greater distance to school index (OR: 0.89, 95% CI: 0.88–0.90) were both negatively associated with ACTS. The perceived importance of living closer to school and of road and neighborhood safety was positively associated with ACTS, with a stronger association in boys than in girls for neighborhood safety. On the contrary, the perceived importance of having people to walk with was negatively associated with ACTS, with a stronger association in girls (OR: 0.74, 95% CI: 0.65–0.84) than in boys (OR: 0.77, 95% CI: 0.66–0.88).DiscussionThis study provides insights into perceived social and environmental correlates associated with ACTS behavior. Future research should include gender-specific perceptions and more in-depth investigations of correlates encouraging ACTS, especially considering social aspects, safety issues, and the structuring of the environment in different cultural settings.
SARS-CoV-2 spike-protein targeted serology test results and their association with subsequent COVID-19-related outcomes
Authors: Kaufman Harvey W. , Letovsky Stanley , Meyer William A. , Gillim Laura , Assimon Magdalene M. , Kabelac Carly A. , Kroner John W. , Reynolds Shannon L. , Eisenberg Marcia 
Published: July 2023

ImportanceIn the absence of evidence of clinical utility, the United States' Centers for Disease Control and Prevention does not currently recommend the assessment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike-protein antibody levels. Clinicians and their patients, especially immunocompromised patients, may benefit from an adjunctive objective clinical laboratory measure of risk, using SARS-CoV-2 serology.ObjectiveThe aim of this study is to estimate the association between SARS-CoV-2 spike-protein targeted antibody levels and clinically relevant outcomes overall and among clinically relevant subgroups, such as vaccine and immunocompetency statuses.DesignA retrospective cohort study was conducted using laboratory-based data containing SARS-CoV-2 antibody testing results, as well as medical and pharmacy claim data. SARS-CoV-2 testing was performed by two large United States-based reference clinical laboratories, Labcorp® and Quest Diagnostics, and was linked to medical insurance claims, including vaccination receipt, through the HealthVerity Marketplace. Follow-up for outcomes began after each eligible individual's first SARS-CoV-2 semiquantitative spike-protein targeted antibody test, from 16 November 2020 to 30 December 2021.ExposuresExposure is defined as having SARS-CoV-2 spike-protein targeted antibody testing.Main outcomes and measuresStudy outcomes were SARS-CoV-2 infection and a serious composite outcome (hospitalization with an associated SARS-CoV-2 infection or all-cause death). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Propensity score matching was used for confounding covariate control.ResultsIn total, 143,091 (73.2%) and 52,355 (26.8%) eligible individuals had detectable and non-detectable levels of SARS-CoV-2 spike-protein targeted antibodies, respectively. In the overall population, having detectable vs. non-detectable antibodies was associated with an estimated 44% relative reduction in SARS-CoV-2 subsequent infection risk (HR, 0.56; 95% CI 0.53–0.59) and an 80% relative reduction in the risk of serious composite outcomes (HR 0.20; 95% CI 0.15–0.26). Relative risk reductions were observed across subgroups, including among immunocompromised persons.Conclusion and relevanceIndividuals with detectable SARS-CoV-2 spike-protein targeted antibody levels had fewer associated subsequent SARS-CoV-2 infections and serious adverse clinical outcomes. Policymakers and clinicians may find SARS-CoV-2 spike-protein targeted serology testing to be a useful adjunct in counseling patients with non-detectable antibody levels about adverse risks and reinforcing appropriate actions to mitigate such risks.
Emergency department crowding and mortality: an observational multicenter study in Sweden
Authors: Wretborn Jens , Wilhelms Daniel B. , Ekelund Ulf 
Published: July 2023

BackgroundEmergency department (ED) crowding is a serious problem worldwide causing decreased quality of care. It is reasonable to assume that the negative effects of crowding are at least partially due to high staff workload, but previous crowding metrics based on high workload have not been generalisable to Swedish EDs and have not been associated with increased mortality, in contrast to, e.g., occupancy rate. We recently derived and validated the modified Skåne Emergency Department Assessment of Patient Load model (mSEAL) that measures crowding based on staff workload in Swedish EDs, but its ability to identify situations with increased mortality is unclear. In this study, we aimed to investigate the association between ED crowding measured by mSEAL model, or occupancy rate, and mortality.MethodsAll ED patients from 2017-01-01 to 2017-06-30 from two regional healthcare systems (Skåne and Östergötland Counties with a combined population of approximately 1.8 million) in Sweden were included. Exposure was ED- and hour-adjusted mSEAL or occupancy rate. Primary outcome was mortality within 7 days of ED arrival, with one-day and 30-day mortality as secondary outcomes. We used Cox regression hazard ratio (HR) adjusted for age, sex, arrival by ambulance, hospital admission and chief complaint.ResultsWe included a total of 122,893 patients with 168,900 visits to the six participating EDs. Arriving at an hour with a mSEAL score above the 95th percentile for that ED and hour of day was associated with an non-significant HR for death at 7 days of 1.04 (95% CI 0.96–1.13). For one- and 30-day mortality the HR was non-significant at 1.03 (95% CI 0.9–1.18) and 1.03 (95% CI 0.97–1.09). Similarly, occupancy rate above the 95th percentile with a HR of 1.04 (95% CI 0.9–1.19), 1.03 (95%CI 0.95–1.13) and 1.04 (95% CI 0.98–1.11) for one-, 7- and 30-day mortality, respectively.ConclusionIn this multicenter study in Sweden, ED crowding measured by mSEAL or occupancy rate was not associated with a significant increase in short-term mortality.
State-level clustering in PrEP implementation factors among family planning clinics in the Southern United States
Authors: Sheth Anandi N. , Enders Kimberly P. , McCumber Micah , Psioda Matthew A. , Ramakrishnan Aditi , Sales Jessica M. 
Published: July 2023

BackgroundAvailability of PrEP-providing clinics is low in the Southern U.S., a region at the center of the U.S. HIV epidemic with significant HIV disparities among minoritized populations, but little is known about state-level differences in PrEP implementation in the region. We explored state-level clustering of organizational constructs relevant to PrEP implementation in family planning (FP) clinics in the Southern U.S.MethodsWe surveyed providers and administrators of FP clinics not providing PrEP in 18 Southern states (Feb-Jun 2018, N = 414 respondents from 224 clinics) on these constructs: readiness to implement PrEP, PrEP knowledge/attitudes, implementation climate, leadership engagement, and available resources. We analyzed each construct using linear mixed models. A principal component analysis identified six principal components, which were inputted into a K-means clustering analysis to examine state-level clustering.ResultsThree clusters (C1–3) were identified with five, three, and four states, respectively. Canonical variable 1 separated C1 and C2 from C3 and was primarily driven by PrEP readiness, HIV-specific implementation climate, PrEP-specific leadership engagement, PrEP attitudes, PrEP knowledge, and general resource availability. Canonical variable 2 distinguished C2 from C1 and was primarily driven by PrEP-specific resource availability, PrEP attitudes, and general implementation climate. All C3 states had expanded Medicaid, compared to 1 C1 state (none in C2).ConclusionConstructs relevant for PrEP implementation exhibited state-level clustering, suggesting that tailored strategies could be used by clustered states to improve PrEP provision in FP clinics. Medicaid expansion was a common feature of states within C3, which could explain the similarity of their implementation constructs. The role of Medicaid expansion and state-level policies on PrEP implementation warrants further exploration.
Thrombocytopenia as an important determinant of poor prognosis in patients with pyogenic liver abscess: a retrospective case series
Authors: Li Sheng-zhong , Liu Shao-hua , Hao Meng , Yu Tian , Hu Song , Liu Li , Liu Zhe-long 
Published: July 2023

BackgroundThrombocytopenia and poor prognosis in severe conditions are associated. However, the clinical significance of thrombocytopenia in pyogenic liver abscess (PLA) has not been evaluated.ObjectiveTo evaluate the association between thrombocytopenia and the prognosis of patients with PLA.MethodsA consecutive case series of 458 adult patients with PLA hospitalized at Tongji Hospital (Wuhan, China) between October 2011 and June 2021 was included in this cross-sectional analysis. Patient data were compared between the thrombocytopenia and non-thrombocytopenia groups. Multivariate logistic regression, receiver operating characteristic (ROC) curve and propensity score -matched analyses (PSM) were performed.ResultsOf the 458 patients with PLA, 94 (20.5%) developed thrombocytopenia, 19 (4.1%) developed septic shock, 14 (3.1%) were admitted to the ICU, and 15 (3.3%) died during hospitalization. Thrombocytopenia was independently associated with shock (95%CI = 3.529–57.944, P &lt; 0.001), ICU admission (95%CI = 1.286–25.733, P = 0.022), and mortality (95%CI = 1.947–34.223, P = 0.004) in multivariate regression analysis. ROC analysis showed that thrombocytopenia may be an identified marker of shock [area under the ROC curve (AUC), 0.8119; cut-off, 92.50; P &lt; 0.0001], ICU admission (AUC, 0.7484; cut-off, 82.50; P &lt; 0.0015), and mortality (AUC, 0.7827; cut-off, 122.50; P &lt; 0.002). These findings remained consistent across 86 pairs of patients analyzed for PSM analyses.ConclusionsThrombocytopenia is an independent risk factor for poor prognosis in PLA and patients may be more prone to adverse outcomes.