bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Age Judaism
Authors: Werczberger Rachel 
Published: April 2023

New Age Judaism, sometimes also called “Jewish Renewal” or “neo-Hasidism,” is an umbrella term used here to describe the loose assemblage of various cultural initiatives and collective individual practices that have emerged in North America and in Israel since the late 1960s under the influence of the counterculture and later the New Age spiritualities. In the framework of American Judaism, New Age Judaism is often used to refer to the style of discourse and practice offered by the Jewish Renewal movement founded and led by the late Rabbi Schachter-Shalomi (b. 1924–d. 2014). However, in this article, the term refers to a much broader phenomenon and includes New Age Kabbalah (neo-Kabbalah); neo-Hasidism; the North American Jewish Renewal movement; New Age–styled hybrid practices such as Torah yoga and Jewish shamanism; and new types of non-affiliated Jewish, spirituality-inclined communities and fellowships. These cultural modalities differ from each other in terms of their commitment to the Jewish law, their emphasis on renewal and personal and collective transformation, and the universalization of Jewish mystical tradition. At the same time they all share the following aspects: a (re)turn to Jewish mystical lore, especially to Kabbalah and Hasidism; eclecticism and hybridity (i.e., openness to non-Jewish spiritual traditions and the willingness to integrate them into the Jewish practice); a critical outlook on institutionalized Judaism; an emphasis on spiritual experiences (i.e., highly personal, subjective, and unmediated experiences of the sacred); and a therapeutic approach and a focus on self-help, self-realization, and development. Some scholars suggest that New Age Judaism is the product of the global New Age culture and postmodern spiritualities pointing to intersection of this new form of Jewish discourse and practice with the broader contemporary spiritualties. Others prefer to study it through the notion of “Jewish spirituality” and its relation to Jewish mystical traditions, namely Kabbalah and Hasidism. Because such cognate topics are represented by separate Oxford Bibliographies in Jewish Studies entries, this article does not directly cover Modern Kabbalah, Hasidism, and Bratslav/Breslev Hasidism. Attracting the attention of anthropologists and ethnographers of contemporary Jewish life, New Age Judaism is often studied using ethnographic methods. Other scholarship takes a more textual and philosophical direction and focuses on the writings of leaders of Jewish New Age groups.
Beyond Skin Rash: Alpelisib-Induced Anaphylactic Reactions
Authors: Schutte Tim , Zeverijn Laurien J , Geurts Birgit S , de Wit Gijsbrecht F , Kok Marleen , Opdam Frans L 
Published: April 2023

Abstract
Alpelisib is a specific oral PI3K inhibitor used combined with fulvestrant for the treatment of patients with HR+/HER2–/PIK3CA-mutated metastatic breast cancer. Adverse drug reactions with alpelisib are common, including hyperglycemia and rash. Here we describe extraordinary and life-threatening reactions beyond skin rash in two patients with progressive PIK3CA-mutated metastatic cancer in whom alpelisib was initiated. Case-A (vaginal cancer): After 10 days on treatment, she developed dry eyes, generalized rash and itching. Alpelisib was interrupted and symptomatic treatment initiated. Because of an initial tumor response, a rechallenge was done. Ninety minutes after a reduced dose of alpelisib, she developed an anaphylactic reaction with angioedema, hypotension, and skin rash. Case-B (breast cancer): After 11 days on treatment, she developed skin rash and alpelisib was interrupted. At re-initiation, she felt tingles in her face and ears and some skin erythema. Given the mild rash, a second rechallenge with premedication was performed. Ninety minutes after a reduced dose of alpelisib, she developed a type-1 allergic reaction with angioedema, tingles, and skin rash. In both cases, a type-1 allergic reaction was diagnosed and symptomatic treatment was initiated, alpelisib was permanently discontinued and the patients fully recovered the next week(s). This report underlines the critical importance to consider type-I allergic reactions in the differential diagnosis in cases of rash associated with alpelisib. Even if a reaction develops after days on treatment, a type-I allergic reaction cannot be excluded. A rechallenge can be dangerous and should always be well contemplated or even avoided.
The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms
Authors: Liu Man , Li Na , Tang Hongzhen , Chen Luohai , Liu Xuemei , Wang Yu , Lin Yuan , Luo Yanji , Wei Shaozhen , Wen Wenli , Chen Minhu , Wang Jiaqian , Zhang Ning , Chen Jie 
Published: April 2023

Abstract

Background
Neuroendocrine neoplasms (NENs) represent clinically and genetically heterogeneous malignancies, thus a comprehensive understanding of underlying molecular characteristics, prognostic signatures, and potential therapeutic targets is urgently needed.

Methods
Next-generation sequencing (NGS) and immunohistochemistry were applied to acquire genomic and immune profiles of NENs from 47 patients.

Results
Difference was distinguished based on differentiation grade and primary localization. Poorly differentiated neuroendocrine carcinomas (NECs) and well-differentiated neuroendocrine tumors (NETs) harbored distinct molecular features; we observed that tumor mutational burden (TMB) and tumor neoantigen burden (TNB) were significantly higher in NECs versus NETs. Notably, we identified a 7-gene panel (MLH3, NACA, NOTCH1, NPAP1, RANBP17, TSC2, and ZFHX4) as a novel prognostic signature in NENs; patients who carried mutations in any of the 7 genes exhibited significantly poorer survival. Furthermore, loss of heterozygosity (LOH) and germline homogeneity in human leukocyte antigen (HLA) are common in NENs, accounting for 39% and 36%, respectively. Notably, HLA LOH was an important prognostic biomarker for a subgroup of NEN patients. Finally, we analyzed clinically actionable targets in NENs, revealing that TMB high (TMB-H) or gene mutations in TP53, KRAS, and HRAS were the most frequently observed therapeutic indicators, which granted eligibility to immune checkpoint blockade (ICB) and targeted therapy.

Conclusion
Our study revealed heterogeneity of NENs, and identified novel prognostic signatures and potential therapeutic targets, which directing improvements of clinical management for NEN patients in the foreseeable future.
Risk Factors for Immune Checkpoint Inhibitor Immunotherapy Toxicity Among Older Adults with Cancer
Authors: Johns Andrew C , Yang Mike , Wei Lai , Grogan Madison , Spakowicz Daniel , Patel Sandipkumar H , Li Mingjia , Husain Marium , Kendra Kari L , Otterson Gregory A , Rosko Ashley E , Andersen Barbara L , Carbone David P , Owen Dwight H , Presley Carolyn J 
Published: April 2023

Abstract

Objectives
Immune checkpoint inhibitor immunotherapy (IO) is revolutionizing cancer care but can lead to significant toxicity. This study seeks to describe potential risk factors for immune-related adverse events (irAEs) specifically among older adults.

Materials and Methods
This was a retrospective study at a single academic comprehensive cancer center based on chart review data abstracted by physicians. For patients aged ≥70 years, frequency, type, and grade of irAEs and their association with baseline patient demographics, comorbidities, mobility, and functional status were characterized using bivariate analysis. Based on those results, multivariable logistic regressions were constructed to model the association between these characteristics with any grade and grade 3 or higher irAEs.

Results
Data were analyzed for 238 patients aged ≥70 years who received IO for mostly (≥90%) advanced cancer between 2011 and 2018. Thirty-nine percent of older adults experienced an irAE and 13% experienced one that was grade 3 or higher. In the multivariable analysis, depression was associated with an increased incidence of any grade irAE, while decreased life-space mobility was associated with an increased incidence of grade ≥3 irAEs.

Conclusion
Most characteristics of special interest among older adults, include fall risk, weight loss, cognitive limitations, and hearing loss, were not associated with irAEs in our study. However, decreased life-space mobility and depression are potential risk factors for IO toxicity among older adults with advanced cancer. Interventions designed to evaluate and mitigate modifiable risk factors for treatment-related toxicity are needed, and the results of this study may be useful for guiding those efforts.
Chytrids alleviate the harmful effect of heat and cyanobacteria diet on Daphnia via PUFA-upgrading
Authors: Abonyi András , Pilecky Matthias , Rasconi Serena , Ptacnik Robert , Kainz Martin J 
Published: April 2023

Abstract
Chytrid fungal parasites increase herbivory and dietary access to essential molecules, such as polyunsaturated fatty acids (PUFA), at the phytoplankton–zooplankton interface. Warming enhances cyanobacteria blooms and decreases algae-derived PUFA for zooplankton. Whether chytrids could support zooplankton with PUFA under global warming scenarios remains unknown. We tested the combined effect of water temperature (ambient: 18°C, heat: +6°C) and the presence of chytrids with Daphnia magna as the consumer, and Planktothrix rubescens as the main diet. We hypothesized that chytrids would support Daphnia fitness with PUFA, irrespective of water temperature. Heating was detrimental to the fitness of Daphnia when feeding solely on the Planktothrix diet. Chytrid-infected Planktothrix diet alleviated the negative impact of heat and could support Daphnia survival, somatic growth and reproduction. Carbon stable isotopes of fatty acids highlighted a ~3x more efficient n-3 than n-6 PUFA conversion by Daphnia feeding on the chytrid-infected diet, irrespective of temperature. The chytrid diet significantly increased eicosapentaenoic acid (EPA; 20:5n-3) and arachidonic acid (ARA; 20:4n-6) retention in Daphnia. The EPA retention remained unaffected, while ARA retention increased in response to heat. We conclude that chytrids support pelagic ecosystem functioning under cyanobacteria blooms and global warming via chytrids-conveyed PUFA toward higher trophic levels.
Cytosolic isocitrate dehydrogenase regulates plant stem cell maintenance in response to nutrient deficiency
Authors: Zhan Sijia , Zhang Qian , Yao Yuhan , Cui Yuchao , Huang Tao 
Published: April 2023

Abstract
WUSCHEL (WUS) and WUSCHEL-RELATED HOMEOBOX (WOX) proteins determine stem cell maintenance for continual plant growth and development under changing environmental conditions. Nutrient availability is an environmental factor that substantially controls plant growth and development. However, how plant stem cell homeostasis is regulated under nutrient deficiency remains to be elucidated. Here, we showed that cytosolic isocitrate dehydrogenase (ICDH) plays an important role in nutrient sensing of stem cells in Arabidopsis (Arabidopsis thaliana). Nutrient deficiency induced the cytoplasmic-to-nuclear translocation of cytosolic ICDH protein. ICDH can interact with WUS/WOX protein as a complex that further promotes WUS/WOX expression by binding to its promoter. WUS/WOX expression in the icdh-2 mutant was lower than that of wild-type plants under nutrient deficiency. Consistently, loss of ICDH function caused a more serious growth repression under nutrient deficiency that was independent of ICDH's catalytic activity. Therefore, cytosolic ICDH regulates stem cell homeostasis of plants in response to nutrient deficiency.
A point mutation in the gene encoding magnesium chelatase I subunit influences strawberry leaf color and metabolism
Authors: Ma Yang-Yang , Shi Jian-Cheng , Wang Dan-Juan , Liang Xia , Wei Feng , Gong Chun-Mei , Qiu Li-Juan , Zhou Hou-Cheng , Folta Kevin M , Wen Ying-Qiang , Feng Jia-Yue 
Published: April 2023

Abstract
Magnesium chelatase (MgCh) catalyzes the insertion of magnesium into protoporphyrin IX, a vital step in chlorophyll (Chl) biogenesis. The enzyme consists of 3 subunits, MgCh I subunit (CHLI), MgCh D subunit (CHLD), and MgCh H subunit (CHLH). The CHLI subunit is an ATPase that mediates catalysis. Previous studies on CHLI have mainly focused on model plant species, and its functions in other species have not been well described, especially with regard to leaf coloration and metabolism. In this study, we identified and characterized a CHLI mutant in strawberry species Fragaria pentaphylla. The mutant, noted as p240, exhibits yellow–green leaves and a low Chl level. RNA-Seq identified a mutation in the 186th amino acid of the CHLI subunit, a base conserved in most photosynthetic organisms. Transient transformation of wild-type CHLI into p240 leaves complemented the mutant phenotype. Further mutants generated from RNA-interference (RNAi) and CRISPR/Cas9 gene editing recapitulated the mutant phenotype. Notably, heterozygous chli mutants accumulated more Chl under low light conditions compared with high light conditions. Metabolite analysis of null mutants under high light conditions revealed substantial changes in both nitrogen and carbon metabolism. Further analysis indicated that mutation in Glu186 of CHLI does not affect its subcellular localization nor the interaction between CHLI and CHLD. However, intramolecular interactions were impaired, leading to reduced ATPase and MgCh activity. These findings demonstrate that Glu186 plays a key role in enzyme function, affecting leaf coloration via the formation of the hexameric ring itself, and that manipulation of CHLI may be a means to improve strawberry plant fitness and photosynthetic efficiency under low light conditions.
Multi-walled carbon nanotubes reversing the bone formation of bone marrow stromal cells by activating M2 macrophage polarization
Authors: Lin Runlian , Ge Kun , Fan Dehui , Li Jing , Zhou Guoqiang , Zhang Kaihan , Huang Yuanyu , Ma Lili , Zhang Jinchao 
Published: April 2023

Abstract
Multi-walled carbon nanotubes (MWCNTs) are an excellent bone tissue repair material both in vitro and in vivo. The interactions between MWCNTs and single type of cells of bone tissue, including osteoblasts, bone marrow stromal cells (BMSCs) or osteoclasts, have been extensively studied. However, the interactions between MWCNTs with different types of cells in the bone microenvironment remain elusive. Bone microenvironment is a complex system composed of different types of cells, which have interactions between each other. In this work, the effects of MWCNTs on bone microenvironment were firstly studied by culture of MWCNTs with BMSCs, osteoblasts, osteoclasts, macrophages and vascular endothelial cells, respectively. Then, co-culture systems of macrophages–BMSCs, macrophages–calvaria and macrophages–BMSCs–vascular endothelial cells were treated with MWCNTs, respectively. The osteogenic differentiation of BMSCs and osteoblasts was inhibited when these two types of cells were cultured with MWCNTs, respectively. Strikingly, when co-culture MWCNTs with BMSCs and macrophages, the osteogenesis of BMSCs was promoted by inducing the M2 polymerization of macrophages. Meanwhile, MWCNTs promoted the bone formation in the osteolysis model of calvaria ex vivo. In addition, the formation of osteoclasts was inhibited, and angiogenesis was increased when treated with MWCNTs. This study revealed the inconsistent effects of MWCNTs on single type of bone cells and on the bone microenvironment. The results provided basic research data for the application of MWCNTs in bone tissue repair.
The impact of traditional cardiovascular risk factor control on 7-year follow-up atherosclerosis progression in systemic lupus erythematosus
Authors: Papazoglou Nikolaos , Kravvariti Evrydiki , Konstantonis George , Sfikakis Petros P , Tektonidou Maria G 
Published: April 2023

Abstract

Objectives
The 2022 EULAR recommendations for cardiovascular risk management in patients with rheumatic disorders, including SLE, call for rigorous management of cardiovascular risk factors (CVRF). The impact of CVRF target attainment on atherosclerotic plaque progression hasn’t been previously evaluated in prospective ultrasound studies.

Methods
A total of 115 patients with SLE and 1:1 age and sex-matched healthy controls who had a baseline carotid and femoral ultrasound examination in our cardiovascular research unit were invited for a 7-year follow-up assessment of new plaque development. We aimed to compare the incidence of plaque progression between SLE patients and controls and reveal the extent to which it is affected by the attainment of European Society of Cardiology (ESC) targets for modifiable CVRFs (blood pressure, smoking status, body weight, lipids and physical activity), and disease-related features (disease duration, disease activity, autoantibodies, treatments).

Results
Eighty-six SLE patients and 42 controls had a 7-year follow-up carotid and femoral plaque examination. New plaque development was observed in 32/86 patients vs 8/42 controls (P = 0.037). Patients with SLE had a 4-fold higher risk for plaque progression than controls (OR: 4.16, CI: 1.22, 14.19, P = 0.023), adjusting for potential confounders. Multivariate regression analyses showed a 50% decrease in plaque progression for every modifiable CVRF fulfilling ESC targets (OR: 0.56, CI: 0.34, 0.93, P = 0.026).

Conclusion
Patients with SLE develop a rapid progression of atherosclerotic plaques which may be drastically reduced by CVRF target attainment according to ESC guidelines.
Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with granulomatosis with polyangiitis
Authors: Lintermans Lucas L , Stegeman Coen A , Muñoz-Elías Ernesto J , Tarcha Eric J , Iadonato Shawn P , Rutgers Abraham , Heeringa Peter , Abdulahad Wayel H 
Published: April 2023

Abstract

Objectives
Granulomatosis with polyangiitis (GPA) is a chronic relapsing systemic autoimmune vasculitis. Current treatment of GPA is unsatisfactory, as it relies on strong immunosuppressive regimens, with either CYC or rituximab, which reduce the immunogenicity of several vaccines and are risk factors for a severe form of COVID-19. This emphasizes the need to identify new drug targets and to develop treatment strategies with less harmful side effects. Since CD4+ effector memory T cells (TEM) play a key role in the pathogenesis of GPA, we aimed in this study to modulate CD4+TEM cell activity via Kv1.3 blockade using the specific peptide inhibiter, ShK-186.

Methods
Peripheral blood samples from 27 patients with GPA in remission and 16 age- and sex-matched healthy controls (HCs) were pre-incubated in vitro in the presence or absence of ShK-186, followed by stimulation with phorbol myristate acetate, calcium ionophore and brefeldin-A. The effect of ShK-186 on the cytokine production (IFNγ, TNFα, IL-4, IL-17, IL-21) within total and subsets of CD4+ T helper (CD4+TH) cells were assessed using flow cytometry.

Results
ShK-186 reduced the expression level of IFNγ, TNFα, IL-4, IL-17 and IL-21 in CD4+TH cells from patients with GPA in vitro. Further analysis performed on sorted CD4+T cell subsets, revealed that ShK-186 predominantly inhibited the cytokine production of CD4+TEM cells. ShK-186 treatment reduced the production of the pro-inflammatory cytokines to the level seen in CD4+ TH cells from HCs.

Conclusions
Modulation of cellular effector function by ShK-186 may constitute a novel treatment strategy for GPA with high specificity and less harmful side effects.
Sleep Problems, Suicidal Ideation, and Psychopathology in First-Episode Psychosis
Authors: Ayers Nolan , McCall William V , Miller Brian J 
Published: April 2023

Abstract

Background and Hypothesis
Insomnia occurs frequently in the clinical course of schizophrenia. A growing literature has found associations between insomnia, suicidal ideation and behavior, and psychopathology in schizophrenia. We explored associations between sleep problems, suicidal ideation, and psychopathology in a cohort of patients with first-episode psychosis.

Study Design
We performed a secondary analysis of data for n = 403 subjects with data from the Recovery After an Initial Schizophrenia Episode study using regression models.

Study Results
The prevalence of sleep problems and suicidal ideation at baseline was 57% and 15%, respectively. After controlling for potential confounders, in the study baseline sleep problems were associated with increased odds of suicidal ideation with evidence of a dose-dependent relationship (OR = 2.25, 95% CI 1.15–4.41, P = .018). Over 24 months, sleep problems at any time point were associated with an over 3-fold increased odds of concurrent suicidal ideation (OR = 3.21, 95% CI 1.45–7.14, P = .004). Subjects with persistent sleep problems were almost 14 times more likely to endorse suicidal ideation at least once over the study than those without sleep problems (OR = 13.8, 95% CI 6.5–53.4, P &lt; .001). Sleep problems were also a predictor of higher Positive and Negative Syndrome Scale total (β = 0.13–0.22), positive (β = 0.14–0.25), and general (β = 0.16–0.27) subscale scores at baseline and multiple follow-up visits (P &lt; .01 for each).

Conclusions
Sleep problems are highly prevalent and associated with suicidal ideation and greater psychopathology in first-episode psychosis. Formal assessment and treatment of insomnia appear relevant to the clinical care of patients with psychosis as a predictor of suicidal ideation and symptom severity.
Parental Leave Reforms in South Korea, 1995–2021: Policy Translation and Institutional Legacies
Authors: Kim Yeonjin , Lundqvist Åsa 
Published: April 2023

Abstract
This article aims to explore how policy translation and institutional legacies have shaped South Korean parental leave policies between 1995 and 2021. It draws on a document analysis of central political documents and interviews with a number of key policy actors in South Korea. The findings show that reforms of parental leave policies were implemented according to four major rationales: maternity protection; combating low-fertility rates; (working mothers’) work–family life reconciliation; and, finally, men's involvement in childcare. Swedish parental leave policies, especially the introduction of the quota system (the “daddy month”), served as inspiration. The current design of Korean parental leave differs, however, from that of Sweden, and is analyzed as a result of localized reforms surrounding plummeting fertility rates and institutional legacies, mainly connected to the organization of the labor market.
Single-Cell RNA Sequencing ofSox17-Expressing Lineages Reveals Distinct Gene Regulatory Networks and Dynamic Developmental Trajectories
Authors: Trinh Linh T , Osipovich Anna B , Liu Bryan , Shrestha Shristi , Cartailler Jean-Philippe , Wright Christopher V E , Magnuson Mark A 
Published: April 2023

AbstractDuring early embryogenesis, the transcription factor SOX17 contributes to hepato-pancreato-biliary system formation and vascular-hematopoietic emergence. To better understand Sox17 function in the developing endoderm and endothelium, we developed a dual-color temporal lineage-tracing strategy in mice combined with single-cell RNA sequencing to analyze 6934 cells from Sox17-expressing lineages at embryonic days 9.0-9.5. Our analyses showed 19 distinct cellular clusters combined from all 3 germ layers. Differential gene expression, trajectory and RNA-velocity analyses of endothelial cells revealed a heterogenous population of uncommitted and specialized endothelial subtypes, including 2 hemogenic populations that arise from different origins. Similarly, analyses of posterior foregut endoderm revealed subsets of hepatic, pancreatic, and biliary progenitors with overlapping developmental potency. Calculated gene-regulatory networks predict gene regulons that are dominated by cell type-specific transcription factors unique to each lineage. Vastly different Sox17 regulons found in endoderm versus endothelial cells support the differential interactions of SOX17 with other regulatory factors thereby enabling lineage-specific regulatory actions.