bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design thinking for innovation in sustainable built environments: a systematic literature review
Authors: Tantiyaswasdikul Kallaya 
Published: September 2023

PurposeThis systematic literature review investigates the contribution of design thinking (DT) as a process and tool to drive innovation in a sustainable built environment (SBE) and develops a new model for sustainability research integrating DT and future thinking approaches toward achieving a unified DT and foresight notion for future research and applications.Design/methodology/approachThis review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Open-access English articles published between 2000 and 2022 identified using the EBSCOhost, Emerald Insight, DOJA, JSTOR, Scopus and Taylor and Francis database searches were reviewed. The review framework deploys a previously proposed modified Ansoff matrix with an integrated innovation matrix to identify and analyze the challenges and opportunities for innovation growth in SBE. Additionally, a citation analysis was conducted to explore the impact of DT for innovation in SBE, and a proposed framework based on design by drawing on foresight theory was developed.FindingsResearch on DT for innovation in SBE faces the challenge of unanticipated impacts. According to the average number of citations per document, innovation associated with new solutions within a new context seems to become highly influential. Additionally, research gaps exist in the integration of foresight and DT into sustainability research to identify new contexts and solutions to SBE. A model of foresight design thinking (FDT) is proposed to guide future research and support the practical application of DT in sustainability.Research limitations/implicationsThis analysis was limited by the selection criteria as only certain keywords were used and English-only articles were selected. Future research should consider the use of DT for innovation in SBE using various important keywords, which would improve research findings and expand the contribution of DT to SBE.Practical implicationsThe FDT model offers a new holistic framework for the iterative process of reframing and reperception, focusing on divergent and convergent thinking with the goal of contributing to SBE practices.Social implicationsThe integrated framework of DT and foresight can contribute to the study and development of sustainable innovation and a strategic shift toward a sustainable society.Originality/valueThe integration of DT, foresight and sustainability can broaden the horizons of sustainability research by systematically addressing future challenges related to SBE, which can be translated into feasible and innovative solutions. Thus, the FDT model complements the application of DT in sustainable innovation in this research field.
Siderophore‐producing Pantoea ferrattrahens sp. nov. isolated from a clinical specimen and Pantoea ferramans sp. nov. isolated from soil at the bottom of a pond
Authors: Kutsuna Ryo , Miyoshi‐Akiyama Tohru , Muramatsu Yuki , Hamada Moriyuki , Tomida Junko , Kikuchi Ken , Kawamura Yoshiaki 
Published: September 2023

AbstractTwo Gram‐negative facultative anaerobes were isolated from a sepsis patient with pancreatic cancer (strain PAGU 2156T) and soil at the bottom of a pond (strain PAGU 2198T), respectively. These two strains formed haloes around the colonies on chrome azurol S agar plates, indicating the production of siderophores. Two isolates assigned to the genus Pantoea based on the 16S rRNA gene were differentiated from established species by using polymorphic taxonomies. Phylogenetic analysis using four housekeeping genes (gyrB, rpoB, atpD, and infB) showed that strain PAGU 2156T is closely related to Pantoea cypripedii LMG 2657T (89.9%) or Pantoea septica LMG 5345T (95.7%). Meanwhile, strain PAGU 2198T formed a single clade with Pantoea rodasii DSM 26611T (93.6%) and Pantoea rwandensis DSM 105076T (93.3%). The average nucleotide identity values obtained from the draft genome assembly showed ≤90.2% between strain PAGU 2156T and closely related species and ≤81.5% between strain PAGU 2198T and closely related species. Based on various phenotypes, biochemical properties, and whole‐cell fatty acid composition compared with related species, it was concluded that each strain should be classified as a new species of the genus Pantoea. In this manuscript, Pantoea ferrattrahens sp. nov. and Pantoea ferramans sp. nov. with strain PAGU 2156T (=NBRC 115930T = CCUG 76757T) and strain PAGU 2198T (=NBRC 114265T = CCUG 75151T) are proposed as each type strain.
Assessing the sensitivity and resistance of communities in a changing environment
Authors: Sæther Bernt‐Erik , Engen Steinar , Solbu Erik Blystad 
Published: September 2023

Abstract

We propose that the ecological resilience of communities to permanent changes of the environment can be based on how variation in the overall abundance of individuals affects the number of species. Community sensitivity is defined as the ratio between the rate of change in the log expected number of species and the rate of change in the log expected number of individuals in the community. High community sensitivity means that small changes in the total abundance strongly impact the number of species. Community resistance is the proportional reduction in expected number of individuals that the community can sustain before expecting to lose one species. A small value of community resistance means that the community can only endure a small reduction in abundance before it is expected to lose one species.

Based on long‐term studies of four bird communities in European deciduous forests at different latitudes large differences were found in the resilience to environmental perturbations. Estimating the variance components of the species abundance distribution revealed how different processes contributed to the community sensitivity and resistance. Species heterogeneity in the population dynamics was the largest component, but its proportion varied among communities. Species‐specific response to environmental fluctuations was the second major component of the variation in abundance.

Estimates of community sensitivity and resistance based on data only from a single year were in general larger than those based on estimates from longer time series. Thus, our approach can provide rapid and conservative assessment of the resilience of communities to environmental changes also including only short‐term data.

This study shows that a general ecological mechanism, caused by increased strength of density dependence due to reduction in resource availability, can provide an intuitive measure of community resilience to environmental variation. Our analyses also illustrate the importance of including specific assumptions about how different processes affect community dynamics. For example, if stochastic fluctuations in the environment affect all species in a similar way, the sensitivity and resistance of the community to environmental changes will be different from communities in which all species show independent responses.
Genotypic variations and interspecific interactions modify gene expression and biofilm formation of Xanthomonas retroflexus
Authors: Jacquiod Samuel , Olsen Nanna Mee Coops , Blouin Manuel , Røder Henriette Lyng , Burmølle Mette 
Published: September 2023

AbstractMultispecies biofilms are important models for studying the evolution of microbial interactions. Co‐cultivation of Xanthomonas retroflexus (XR) and Paenibacillus amylolyticus (PA) systemically leads to the appearance of an XR wrinkled mutant (XRW), increasing biofilm production. The nature of this new interaction and the role of each partner remain unclear. We tested the involvement of secreted molecular cues in this interaction by exposing XR and XRW to PA or its supernatant and analysing the response using RNA‐seq, colony‐forming unit (CFU) estimates, biofilm quantification, and microscopy. Compared to wild type, the mutations in XRW altered its gene expression and increased its CFU number. These changes matched the reported effects for one of the mutated genes: a response regulator part of a two‐component system involved in environmental sensing. When XRW was co‐cultured with PA or its supernatant, the mutations effects on XRW gene expression were masked, except for genes involved in sedentary lifestyle, being consistent with the higher biofilm production. It appears that the higher biofilm production was the result of the interaction between the genetic context (mutations) and the biotic environment (PA signals). Regulatory genes involved in environmental sensing need to be considered to shed further light on microbial interactions.
Countering ‘the moral science of biopolitics’: Understanding hepatitis C treatment ‘non‐compliance’ in the antiviral era
Authors: Moore David , Fraser Suzanne , Farrugia Adrian , Fomiatti Renae , Edwards Michael , Birbilis Elizabeth , Treloar Carla 
Published: September 2023

AbstractAlthough new hepatitis C treatments are a vast improvement on older, interferon‐based regimens, there are those who have not taken up treatment, as well as those who have begun but not completed treatment. In this article, we analyse 50 interviews conducted for an Australian research project on treatment uptake. We draw on Berlant’s (2007, Critical Inquiry, 33) work on ‘slow death’ to analyse so‐called ‘non‐compliant’ cases, that is, those who begin but do not complete treatment or who do not take antiviral treatment as directed. Approached from a biomedical perspective, such activity does not align with the neoliberal values of progress, self‐improvement and rational accumulation that pervade health discourses. However, we argue that it is more illuminating to understand them as cases in which sovereignty and agency are neither simplistically individualised nor denied, and where ‘modes of incoherence, distractedness, and habituation’ are understood to co‐exist alongside ‘deliberate and deliberative activity […] in the reproduction of predictable life’ (Berlant, 2007, p. 754). The analysed accounts highlight multiple direct and indirect forces of attrition and powerfully demonstrate the socially produced character of agency, a capacity that takes shape through the constraining and exhausting dynamics of life in conditions of significant disadvantage.
Temporal lobe uncal herniation with contralateral superior cerebellar artery infarct
Authors: Chang Koping , Vincenti Donna M. , Troncoso Juan C. 
Published: September 2023

AbstractHerniation of the temporal lobe uncus typically leads to the compression of the ipsilateral oculomotor nerve, resulting in ipsilateral mydriasis, as well as compression of the ipsilateral posterior cerebral artery, leading to infarction in the posterior inferior temporal lobe and medial occipital cortex. In this report, we present the case of a 45‐year‐old man with a large left subdural hematoma. At autopsy, we observed left cingulate and uncal herniations, along with the characteristic lesions of Kernohan notch phenomenon due to compression of the contralateral cerebral peduncle. Additionally, a hemorrhagic infarct was identified in the right cerebellar hemisphere in the distribution of the superior cerebellar artery (SCA). This case provides the first autopsy report of uncal herniation with contralateral SCA infarct, an extremely rare condition. Importantly, this vascular complication may often go unnoticed in patients with Kernohan notch phenomenon although it may carry a grave clinical prognosis.
A critical review on antiviral peptides derived from viral glycoproteins and host receptors to decoy herpes simplex virus
Authors: Rahangdale Rakesh , Tender Tenzin , Balireddy Sridevi , Goswami Kamini , Pasupuleti Mukesh , Hariharapura Raghu Chandrashekar 
Published: September 2023

AbstractThe health of the human population has been continuously challenged by viral infections. Herpes simplex virus (HSV) is one of the common causes of illness and can lead to death in immunocompromised patients. Existing anti‐HSV therapies are not completely successful in eliminating the infection due to anti‐viral drug resistance, ineffectiveness against the latent virus and high toxicity over prolonged use. There is a need to update our knowledge of the current challenges faced in anti‐HSV therapeutics and realize the necessity of developing alternative treatment approaches. Protein therapeutics are now being explored as a novel approach due to their high specificity and low toxicity. This review highlights the significance of HSV viral glycoproteins and host receptors in the pathogenesis of HSV infection. Proteins or peptides derived from HSV glycoproteins gC, gB, gD, gH and host cell receptors (HSPG, nectin and HVEM) that act as decoys to inhibit HSV attachment, entry, or fusion have been discussed. Few researchers have tried to improve the efficacy and stability of the identified peptides by modifying them using a peptidomimetic approach. With these efforts, we think developing an alternative treatment option for immunocompromised patients and drug‐resistant organisms is not far off.
Aging and urinary control: Alterations in the brain–bladder axis
Authors: Hardy Cara C. , Korstanje Ron 
Published: September 2023

AbstractAge‐associated alterations in bladder control affect millions of older adults, with a heavy burden added to families both economically and in quality of life. Therapeutic options are limited with poor efficacy in older adults, lending to a growing need to address the gaps in our current understanding of urinary tract aging. This review summarizes the current knowledge of age‐associated alterations in the structure and function of the brain–bladder axis and identifies important gaps in the field that have yet to be addressed. Urinary aging is associated with decreased tissue responsiveness, decreased control over the voiding reflex, signaling dysfunction along the brain–bladder axis, and structural changes within the bladder wall. Studies are needed to improve our understanding of how age affects the brain–bladder axis and identify genetic targets that correlate with functional outcomes.
Correlation between emotion dysregulation and mood symptoms of bipolar disorder: A systematic review and meta‐analysis
Authors: Oliva Vincenzo , De Prisco Michele , Fico Giovanna , Possidente Chiara , Fortea Lydia , Montejo Laura , Anmella Gerard , Hidalgo‐Mazzei Diego , Grande Iria , Murru Andrea , Fornaro Michele , de Bartolomeis Andrea , Dodd Alyson , Fanelli Giuseppe , Fabbri Chiara , Serretti Alessandro , Vieta Eduard , Radua Joaquim 
Published: September 2023

AbstractBackgroundEmotion dysregulation (ED) is a transdiagnostic construct characterized by difficulties regulating intense emotions. People with bipolar disorder (BD) are more likely to show ED and use maladaptive emotion regulation strategies than adaptive ones. However, little is known about whether ED in BD is a trait or it is rather an epiphenomenon of mood symptoms.MethodsWe conducted a systematic review and meta‐analysis of the evidence across major literature databases reporting correlations between measures of emotion regulation (overall ED and different emotion regulation strategies) and measures of depressive and (hypo)manic symptoms in BD from inception until April 12th, 2022.ResultsFourteen studies involving 1371 individuals with BD were included in the qualitative synthesis, of which 11 reported quantitative information and were included in the meta‐analysis. ED and maladaptive strategies were significantly higher during periods with more severe mood symptoms, especially depressive ones, while adaptive strategies were lower.ConclusionED significantly correlates with BD symptomatology, and it mainly occurs during mood alterations. ED may be a target for specific psychotherapeutic and pharmacological treatments, according to precision psychiatry. However, further studies are needed, including patients with mood episodes and longitudinal design, to provide more robust evidence and explore the causal direction of the associations.
Environmental suitability and potential range expansion of the Eurasian beaver in Italy
Authors: Falaschi Mattia , Ficetola Gentile Francesco , Viviano Andrea , Mazza Giuseppe , Mori Emiliano 
Published: September 2023

AbstractReintroduction and rewilding initiatives are key strategies to reverse human impacts on ecosystems and re‐establish natural processes. However, rewilding may involve complex management scenarios, because many expanding species can have economic impacts and cause human–wildlife conflicts. Conflicts can be particularly challenging when carnivores, large herbivores and ecosystem engineers are involved. The Eurasian beaver (Castor fiber) is a key ecosystem engineer that was once present in a large part of the Palearctic, but in Medieval times underwent a severe decline due to the joint effects of habitat loss and hunting. Subsequent legal protection and reintroductions triggered the recovery of the species through most of its original range. Eurasian beavers recently started the recolonization of Italy, because of the joint effects of natural dispersal (from Austria to northern Italy) and illegal reintroductions (central Italy). The lack of data on the most likely colonization routes hampers appropriate management of this species. Here, we identified the areas where beaver populations are most likely to arrive in the near future within Europe, with a specific focus on Italy. First, we developed spatially cross‐validated species distribution models to identify the areas with the highest suitability for the Eurasian beaver in Europe. Second, we used connectivity modelling to assess the possible expansion routes of this species in Italy. Large areas of Europe are suitable for the beaver and may soon be colonized. The connectivity model showed a high potential for expansion from central Italy to surrounding areas, while the high isolation of northern Italy populations suggests a slower expansion. Our results can help environmental managers to understand where to focus both the future monitoring of beaver populations and actions aimed at preventing and mitigating possible human–wildlife conflicts that could arise from the expansion of an environmental engineer such as the beaver.
Posthatch developmental changes in the ovary with emphasis on follicular development and atresia in the native chicken (Uttara fowl) of Uttarakhand, India
Authors: Mohd Khan Idrees , Saleem Rabab , Choudhary Om Prakash , Singh Ishwar 
Published: September 2023

AbstractThis experiment was designed to investigate the postnatal development of the ovary in the Uttara fowl chicken and was conducted on 54 apparently healthy female birds divided into different age groups, namely Day 1 and Weeks 1, 4, 8, 12, 16, 20, 24, 28 with six birds each. During postnatal development, the left ovary gradually increased in size and complexity. The segmentation of the ovary started by 4 weeks, follicular eruption by 8 weeks, small liquor follicles (1–5 mm) appeared by 16 weeks, pre‐hierarchical follicles by 20 weeks and hierarchical follicles by 24 weeks of age. The cortex was distinctly differentiated from the medulla in the early stage of ovarian development. However, the division between cortex and medulla was gradually obscured with age (transitional stage) and distinction was completely lost in the mature ovary. The different stages of follicular development in the chicken ovary were classified as primordial, primary, growing at Stage I, II and III stromal follicles besides pre‐hierarchical and hierarchical surface follicles. The primordial and primary follicles showed cytoplasmic sudanophilic substances, especially in the Balbiani's yolk body, indicating the presence of lipids (Sudan Black B) with no activity for neutral polysaccharides (periodic acid Schiff method). It was observed that apoptotic changes may affect any stage of developing follicle resulting in arrested growth and atrophy. An early form of follicular atresia was the fate of the growth‐arrested primordial and primary follicles, whereas the glandular form of atresia was commonly observed in growing follicles arrested at Stages I and II. The scanning electron micrographs unveiled the follicles as hollow oval structures with a follicular lumen lined by the perivitelline membrane (glycoprotein membrane) having lacunae giving a honeycomb‐like appearance.
Association between immunity and different clinical symptoms in patients with polycystic ovary syndrome
Authors: Xiao Huan , Yin Tailang , Diao Lianghui , Zhang Yan , Huang Chunyu 
Published: September 2023

AbstractPolycystic ovary syndrome (PCOS) is a disease with endocrine and metabolic disorders. The main symptoms are hyperandrogenemia (HA), insulin resistance (IR), and ovulation disorder. However, the pathogenesis and pathophysiological process of these major symptoms in PCOS are still not well defined. In recent studies, the chronic low‐grade inflammatory state has become one of the factors affecting PCOS. Some alterable immune factors in PCOS, such as interleukin‐15 and interleukin‐1, have been identified to be related to androgen synthesis and insulin resistance in PCOS. In addition, a disturbed immune microenvironment in the ovary leads to impaired follicular growth and ovulation. Previous studies have roughly reviewed the relationship between immunity and PCOS. However, the link between the different clinical manifestations of PCOS and immunity has not been well explored and analyzed. The clinical presentation of each patient is diverse, and symptomatic treatment is mainly used. Therefore, this article reviews several representative immunological factors that affect these three symptoms to explore the underlying mechanism, which will be beneficial for developing new treatment strategies.
Daily solitude and well‐being associations in older dyads: Evidence from daily life assessments
Authors: Zambrano Garza Elizabeth , Pauly Theresa , Choi Yoonseok , Murphy Rachel A. , Linden Wolfgang , Ashe Maureen C. , Madden Kenneth M. , Jakobi Jennifer M. , Gerstorf Denis , Hoppmann Christiane A. 
Published: September 2023

AbstractOlder adults spend significant time by themselves, especially since COVID‐19. Solitude has been associated with positive and negative outcomes. Partners need to balance social connectedness with time for one's own needs. This project examines how individual and partner solitude are associated with daily affect and relationship quality in dyads of older adults and a close other. One‐hundred thirty‐six older adults plus a close other rated their relationship quality and reported affect, solitude, and its characteristics (desired and bothersome) every evening for 10 days. Over and above overall associations, individual and partner effects emerged; when individual desired solitude was up, participants reported more positive affect and their partners less negative affect. When bothersome solitude was up, participants and their partners alike reported more negative affect and less positive affect. Desired solitude was associated with more support, whereas bothersome solitude was associated with less partner support. Findings provide further evidence on the potential benefits of solitude, highlighting the importance of considering the social context of what is often believed to be an individual‐level phenomenon.