bluuebunny/crossref_metadata_2025_split huggingface dataset:
We Are All Monsters
Authors: Mangham Andrew 
Published: February 2023

How the monsters of nineteenth-century literature and science came to define us.
“Was I then a monster, a blot upon the earth, from which all men fled and whom all men disowned?” In We Are All Monsters, Andrew Mangham offers a fresh interpretation of this question uttered by Frankenstein's creature in Mary Shelley's 1818 novel in an expansive exploration of how nineteenth-century literature and science recast the monster as vital to the workings of nature and key to unlocking the knowledge of all life forms and processes. Even as gothic literature and freak shows exploited an abiding association between abnormal bodies and horror, amazement, or failure, the development of monsters in the ideas and writings of this period showed the world to be dynamic, varied, plentiful, transformative, and creative.
In works ranging from Comte de Buffon's interrogations of humanity within natural history to Hugo de Vries's mutation theory, and from Shelley's artificial man to fin de siècle notions of body difference, Mangham expertly traces a persistent attempt to understand modern subjectivity through a range of biological and imaginary monsters. In a world that hides monstrosity behind theoretical and cultural representations that reinscribe its otherness, this enlightened book shows how innovative nineteenth-century thinkers dismantled the fictive idea of normality and provided a means of thinking about life in ways that check the reflexive tendency to categorize and divide.
#You Know You're Black in France When…
Authors: Keaton Trica 
Published: February 2023

A groundbreaking study about everyday antiblackness and its refusal in an officially raceblind France.
What does it mean to be racialized-as-black in France on a daily basis? #You Know You're Black in France When… responds to that question. Under the banner of universalism, France messages a powerful and seductive ideology of blindness to race that disappears blackened people and the antiblackness they experience. As Trica Keaton notes, in everyday life, France is anything but raceblind.
In this interdisciplinary study, drawn from a range of critical scholarship including that of Philomena Essed and Frantz Fanon, Keaton illuminates how b/Black (racialized/politicized) French people distinctly expose and refuse what she calls “raceblind republicanism.” By officially turning a blind eye to the specificity of antiblackness, the French state in fact perpetuates it, she argues, along with structural racism. Through daily life, public policies, visual culture, the private lives of individuals and families shattered by police violence, the French courts where many are fighting back, and her own experiences, Keaton charts the troubling dynamics and continuities of antiblackness in French society.
Serologic Screening for Genital Herpes Infection
Authors:   US Preventive Services Task Force, Mangione Carol M. , Barry Michael J. , Nicholson Wanda K. , Cabana Michael , Chelmow David , Coker Tumaini Rucker , Davis Esa M. , Donahue Katrina E. , Jaén Carlos Roberto , Kubik Martha , Li Li , Ogedegbe Gbenga , Pbert Lori , Ruiz John M. , Stevermer James , Wong John B. 
Published: February 2023

ImportanceGenital herpes is a common sexually transmitted infection caused by 2 related viruses, herpes simplex type 1 (HSV-1) and herpes simplex type 2 (HSV-2). Infection is lifelong; currently, there is no cure for HSV infection. Antiviral medications may provide clinical benefits to symptomatic persons. Transmission of HSV from a pregnant person to their infant can occur, most commonly during delivery; when genital lesions or prodromal symptoms are present, cesarean delivery can reduce the risk of transmission. Neonatal herpes infection is uncommon yet can result in substantial morbidity and mortality.ObjectiveTo reaffirm its 2016 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a reaffirmation evidence update on targeted key questions to systematically evaluate the evidence on accuracy, benefits, and harms of routine serologic screening for HSV-2 infection in asymptomatic adolescents, adults, and pregnant persons.PopulationAdolescents and adults, including pregnant persons, without known history, signs, or symptoms of genital HSV infection.Evidence AssessmentThe USPSTF concludes with moderate certainty that the harms outweigh the benefits for population-based screening for genital HSV infection in asymptomatic adolescents and adults, including pregnant persons.RecommendationThe USPSTF recommends against routine serologic screening for genital HSV infection in asymptomatic adolescents and adults, including pregnant persons. (D recommendation)
Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction
Authors: Okafor Chinenye M. , Zhu Cenjing , Raparelli Valeria , Murphy Terrence E. , Arakaki Andrew , D’Onofrio Gail , Tsang Sui W. , Smith Marcella Nunez , Lichtman Judith H. , Spertus John A. , Pilote Louise , Dreyer Rachel P. 
Published: February 2023

ImportanceAmong younger adults, the association between Black race and postdischarge readmission after hospitalization for acute myocardial infarction (AMI) is insufficiently described.ObjectivesTo examine whether racial differences exist in all-cause 1-year hospital readmission among younger adults hospitalized for AMI and whether that difference retains significance after adjustment for cardiac factors and social determinants of health (SDOHs).Design, Setting, and ParticipantsThe VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients) study was an observational cohort study of younger adults (aged 18-55 years) hospitalized for AMI with a 2:1 female-to-male ratio across 103 US hospitals from January 1, 2008, to December 31, 2012. Data analysis was performed from August 1 to December 31, 2021.Main Outcomes and MeasuresThe primary outcome was all-cause readmission, defined as any hospital or observation stay greater than 24 hours within 1 year of discharge, identified through medical record abstraction and clinician adjudication. Logistic regression with sequential adjustment evaluated racial differences and potential moderation by sex and SDOHs. The Blinder-Oaxaca decomposition quantified how much of any racial difference was explained and not explained by covariates.ResultsThis study included 2822 participants (median [IQR] age, 48 [44-52] years; 1910 [67.7%] female; 2289 [81.1%] White and 533 [18.9%] Black; 868 [30.8%] readmitted). Black individuals had a higher rate of readmission than White individuals (210 [39.4%] vs 658 [28.8%], P &amp;lt; .001), particularly Black women (179 of 425 [42.1%]). After adjustment for sociodemographic characteristics, cardiac factors, and SDOHs, the odds of readmission were 34% higher among Black individuals (odds ratio [OR], 1.34; 95% CI, 1.06-1.68). The association between Black race and 1-year readmission was positively moderated by unemployment (OR, 1.68; 95% CI, 1.09- 2.59; P for interaction = .02) and fewer number of working hours per week (OR, 1.01; 95% CI, 1.00-1.02; P for interaction = .01) but not by sex. Decomposition indicates that 79% of the racial difference in risk of readmission went unexplained by the included covariates.Conclusions and RelevanceIn this multicenter study of younger adults hospitalized for AMI, Black individuals were more often readmitted in the year following discharge than White individuals. Although interventions to address SDOHs and employment may help decrease racial differences in 1-year readmission, more study is needed on the 79% of the racial difference not explained by the included covariates.
Deep Eutectic Solvents‐Based Ionogels with Ultrafast Gelation and High Adhesion in Harsh Environments
Authors: Ge Gang , Mandal Kalpana , Haghniaz Reihaneh , Li Mengchen , Xiao Xiao , Carlson Larry , Jucaud Vadim , Dokmeci Mehmet Remzi , Ho Ghim Wei , Khademhosseini Ali 
Published: February 2023

AbstractAdhesive materials have recently drawn intensive attention due to their excellent sealing ability, stimulating advances in materials science and industrial usage. However, reported adhesives usually exhibit weak adhesion strength, require high pressure for strong bonding, and display severe adhesion deterioration in various harsh environments. In this study, instead of water or organic solvents, a deep eutectic solvent (DES) is used as the medium for the photopolymerization of zwitterionic and polarized monomers, thus generating a novel ionogel with tunable mechanical properties. Multiple hydrogen bonds and electrostatic interactions between DES and monomers facilitated ultrafast gelation and instant bonding without any external pressure, which has rarely been reported previously. Furthermore, high adhesion in different harsh environments (e.g., water, acidic and basic buffers, and saline solutions) and onto hydrophilic (e.g., glass and tissues) and hydrophobic (e.g., polymethyl methacrylate, polystyrene, and polypropylene) adherends is demonstrated. Also, the high stretchability of the ionogel at extreme temperatures (−80 and 80 °C) indicates its widespread applications. Furthermore, the biocompatible ionogel shows high burst pressure onto stomach and intestine tissues to prevent liquid leakage, highlighting its potential as an adhesive patch. This ionogel provides unprecedented opportunities in the packaging industry, marine engineering, medical adhesives, and electronic assembly.
A Bioinspired Polymer‐Based Composite Displaying Both Strong Adhesion and Anisotropic Thermal Conductivity
Authors: Zhang Heng , He Qingxia , Yu Huitao , Qin Mengmeng , Feng Yiyu , Feng Wei 
Published: February 2023

AbstractThe integration and functionality of high‐power electronic architectures or devices require a high strength and good heat flow at the interface. However, simultaneously improving the interfacial bonding and phonon transport of polymers is challenging because of the tradeoff between the cross‐linked flexible chains and high‐quality crystalline structure. Here, a copolymer, poly(dopamine methacrylate‐co‐hydroxyethyl methacrylate [P(DMA‐HEMA)] is designed and synthesized, inspired by the snail and mussel adhesion. The copolymer achievs a high surface adhesion up to 6.38 MPa owing to the synergistic effects of hydrogen bonds and mechanical interlocking. When the copolymer is introduced into vertically aligned carbon nanotubes (VACNTs), the catechol groups in P(DMA‐HEMA) formed strong bonding with the nanotubes through π‐π interactions at the interface. As a result, the P(DMA‐HEMA)/VACNTs composite shows a high through‐plane thermal conductivity (21.46 W m−1 K−1), an in‐plane thermal conductivity that is 3.5 times higher than that of pristine VACNTs, and an extremely low thermal contact resistance (20.27 K mm2 W−1). Furthermore, the composite forms weld‐free high‐strength connections between two pieces of various metals to bridge directional thermal pathways. It also exhibits excellent interfacial heat transfer capability and high reliability even under zero‐pressure conditions.
Engineered Ferritin Nanoparticle Vaccines Enable Rapid Screening of Antibody Functionalization to Boost Immune Responses
Authors: Vu Mai N. , Pilkington Emily H. , Lee Wen Shi , Tan Hyon‐Xhi , Davis Thomas P. , Truong Nghia P. , Kent Stephen J. , Wheatley Adam K. 
Published: February 2023

AbstractEmploying monoclonal antibodies to target vaccine antigens to different immune cells within lymph nodes where adaptive immunity is initiated can provide a mechanism to fine‐tune the magnitude or the quality of immune responses. However, studying the effects of different targeting antibodies head‐to‐head is challenging due to the lack of a feasible method that allows rapid screening of multiple antibodies for their impact on immunogenicity. Here self‐assembling ferritin nanoparticles are prepared that co‐display vaccine antigens and the Fc‐binding domain of Staphylococcal protein A, allowing rapid attachment of soluble antibodies to the nanoparticle surface. Using this tunable system, ten antibodies targeting different immune cell subsets are screened, with targeting to Clec9a associated with higher serum antibody titers after immunization. Immune cell targeting using ferritin nanoparticles with anti‐Clec9a antibodies drives concentrated deposition of antigens within germinal centers, boosting germinal center formation and robust antibody responses. However, the capacity to augment humoral immunity is antigen‐dependent, with significant boosting observed for prototypic ovalbumin immunogens but reduced effectiveness with the SARS‐CoV‐2 RBD. This work provides a rapid platform for screening targeting antibodies, which will accelerate mechanistic insights into optimal delivery strategies for nanoparticle‐based vaccines to maximize protective immunity.
Tumor‐Specific Photothermal‐Therapy‐Assisted Immunomodulation via Multiresponsive Adjuvant Nanoparticles
Authors: Liu Tao , Zhu Man , Chang Xiaowei , Tang Xiaoyu , Yuan Pingyun , Tian Ran , Zhu Zeren , Zhang Yanmin , Chen Xin 
Published: February 2023

AbstractMultiresponsive adjuvant nanoparticles (RMmAGL) are fabricated to perform tumor‐specific photothermal therapy while regulating the behavior of tumor‐associated immune cells for primary tumor eradication and metastasis inhibition. Core–satellite‐like RMmAGL have a core of mannose‐functionalized mesoporous silica nanoparticles loaded with the TLR7 agonist imiquimod (R837@MSN‐mannose) connected via hydrazone bonds to satellites of glutamine (Glu)‐ and lysine (Lys)‐comodified gold nanoparticles (AuNPs‐Glu/Lys). During therapy, the acidic environment in tumor tissue cleaves the hydrazone bonds to release AuNPs‐Glu/Lys, which further accumulate in tumor cells. After internalization, photothermal agents (aggregated AuNPs‐Glu/Lys) are generated in situ through the intratumoral enzyme‐catalyzed reaction between Glu and Lys, resulting in tumor‐specific photothermal therapy. The detachment of AuNPs‐Glu/Lys also triggers the release of R837, which matured dendritic cells (DCs) via a vaccine‐like mechanism along with the tumor‐associated antigens generated by photothermal therapy. These matured DCs further activates surrounding T cells for immunotherapy. Moreover, the resulting free MSN‐mannose serves as an artificial glycocalyx to continuously induce the polarization of tumor‐associated macrophages from an immunosuppressive phenotype to an inflammatory phenotype, thus further enhancing immunotherapy. Both in vivo and in vitro experiments demonstrate significant inhibition of malignant tumors after therapy.
2‐Hydroxypropyl Group Linked Derivatives of Indole Azoles as Potential Multifunctional Antibacterial Candidates for Effectively Inhibiting the Activity of MRSA and Responding Inflammatory Factors
Authors: Hu Yuanyuan , Zhou Hao , Huang Jinxu , Pan Guangxing , Wang Hao , Wang Tiansheng , Yu Congwei , Zhang Ling , Gou Deming , Zhang Jiaheng 
Published: February 2023

AbstractThe increasing resistance of methicillin‐resistant Staphylococcus aureus (MRSA) to antibiotics has led to escalating efforts to design and synthesize new structural agents with significant antimicrobial potential. A novel class of 2‐hydroxypropyl group linked derivatives of indole azoles was developed as potential antibacterial agents. Bioactivity screening results demonstrated that metronidazole‐modified indole derivative 4 a had excellent antibacterial capacity against MRSA (MIC=6 μM), which was about 4 times that of norfloxacin (MIC=25 μM). Highly active hybrid 4 a did not cause obvious drug‐resistance in MRSA after multiple generations (15 passage operations). Compound 4 a showed low toxicity to normal mammalian cells (RAW 264.7). Molecular docking and molecular electrostatic potential (MEP) surface studies were used to map hydrogen bond interactions and the electron distribution in the highly active compounds. In addition, the preliminary exploration of the antibacterial mechanism revealed that the active molecule 4 a could infiltrate the membrane of MRSA and insert into MRSA DNA to prevent its replication, thus activating strong inhibition of the bacteria. Furthermore, highly active derivative 4 a could better respond to inflammatory factors (IL‐6, IL‐10, TNF‐α and PGE‐2), and it is less likely to cause inflammatory complications, hence diversifying the functions of antibacterial candidate molecules. These findings effectively indicate the potential of the bioactive hybrid 4 a as a multifunctional anti‐MRSA agent. Further exploration of the development of antimicrobials combining these kinds of 2‐hydroxypropyl group linked indole derivatives is of great value.
Synthesis and Optoelectronic Features of Rhodamine‐Triazole Dyads as Metallochromic Probes for Copper‐Selective Chemosensing
Authors: Vadivelu Murugan , Raheem Abbasriyaludeen Abdul , Shankar Bhaskaran , Karthikeyan Kesavan , Praveen Chandrasekar 
Published: February 2023

AbstractRhodamine‐based chromic materials have attracted significant interest owing to their cation recognition ability with high sensitivity. However, rhodamine chromophores with controllable sensing selectivity towards transition metal species are only at the advent. Herein, three triazole‐conjugated rhodamine dyads with different peripheral substituents were synthesized. The key triazole precursors required for the desired chemistry were prepared by adopting our recently developed CTAB catalyzed mechano‐click chemistry. Molecular properties derived from photophysics, electrochemistry and surface morphology of the synthesized dyads were analyzed. Furthermore, frontier molecular orbitals, electronic structure and secondary quantum chemical parameters of dyads were also compared. Screening of dyads for their sensing ability towards an array of alkali, alkaline and transition metal ions exhibited a noticeable naked‐eye detection of Cu2+ ions and was confirmed by spectrophotometric titration. The specific binding mode of dyads as probable with Cu2+ over other metal ions attributes to the chemoselectivity.
Stability analysis for linear time‐varying systems using bicoprime factorization
Authors: Jin Xianglu , Shi Yanyue , Xu Xiaoping 
Published: February 2023

AbstractThis paper presents a bicoprime factorization (BCF) approach to deal with various stability problems for linear discrete time‐varying (LTV) systems within the framework of nest algebra. Based on the bicoprime factorization, we give necessary and sufficient conditions for (strongly) simultaneous stabilization of three systems, which generalize similar results for systems by coprime factorization (CF). Finally, when the bicoprime factorization for the plant and controller has additive perturbations, we derive sufficient conditions using the norm inequality for robust stability of the system.
Investigation of the formation of NDMAUFC across biofilters
Authors: Kent Ashley N. , Russell Caroline G. , Carter Jason T. , Mitch William A. , Hozalski Raymond M. , Huck Peter M. 
Published: February 2023

AbstractFull‐scale sampling at 16 facilities illustrated that NDMA precursor concentrations, measured by adding chloramine under Uniform Formation Conditions (NDMAUFC), increased across biofiltration at 7 of 16 facilities (by 3–48 ng/L or 12%–296%) but stayed the same or decreased (by up to 5 ng/L or 24%) at the other nine facilities. Increases in NDMAUFC concentrations were attributed to both particulate and soluble precursors. Only two facilities had an increase in NDMAUFC greater than 10 ng/L. However, NDMAUFC concentrations in the biofilter effluent from five facilities exceeded 10 ng/L during one or more sampling events. For these facilities, testing at multiple scales showed that mitigation steps could include pretreatment with ozone (which resulted in overall lower NDMAUFC), increased free chlorine contact time prior to ammonia addition, and/or optimized biofilter design and operation.
The ethanol market in Brazil: price behavior and regional differences
Authors: Hoeckel Paulo Henrique , Alvim Augusto 
Published: February 2023

AbstractThe conditions facing the Brazilian ethanol market have created a need to improve the industry's understanding of price formation, and to analyze the effects of mandatory policies and the interaction between Brazil's ethanol, agricultural, and fuel markets. In this context, this study sought to analyze the behavior of ethanol production and consumption at the national and regional levels in Brazil from 2012 to 2016; hence, the supply and demand functions are estimated at national and at regional levels using the two‐stage least squares method. Our findings indicated that gasoline and anhydrous ethanol blended gasoline were substitutes for hydrous ethanol on the demand side in Brazil. At the national level, the estimates also showed that the income elasticity of hydrous ethanol characterizes it as a normal good. At the regional level, the regions with the highest production and consumption (southeastern and central‐western Brazil) responded to price variations less elastically than the other regions (southern, northeastern, and northern Brazil).
Altered rich‐club organization of brain functional network in autism spectrum disorder
Authors: Peng Liling , Chen Zhuang , Gao Xin 
Published: February 2023

AbstractDespite numerous research showing the association between brain network abnormalities and autism spectrum disorder (ASD), contrasting findings have been reported from broad functional underconnectivity to broad overconnectivity. Thus, the significance of rich‐hub organizations in the brain functional connectome of individuals with ASD remains largely unknown. High‐quality data subset of ASD (n = 45) and healthy controls (HC; n = 47) children (7–15 years old) were retrieved from the ABIDE data set, and rich‐club organization and network‐based statistic (NBS) were assessed from resting‐state functional magnetic resonance imaging (rs‐fMRI). The rich‐club organization functional network (normalized rich‐club coefficients >1) was observed in all subjects under a range of thresholds. Compared with HC, ASD patients had higher degree of feeder connections and lower degree of local connections (degree of feeder connections: ASD = 259.20 ± 32.97, HC = 244.98 ± 30.09, p = 0.041; degree of local connections: ASD = 664.02 ± 39.19, HC = 679.89 ± 34.05, p = 0.033) but had similar in rich‐club connections. Further, nonparametric NBS analysis showed the presence of abnormal connectivity in the functional network of ASD individuals. Our findings indicated that local connection might be more vulnerable, and feeder connection may compensate for its disruption in ASD, enhancing our understanding on the mechanism of functional connectome dysfunction in ASD.