bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pan-American Guidelines for the Treatment of SARS-CoV-2/COVID-19: A Joint Evidence-Based Guideline of the Brazilian Society of Infectious Diseases (SBI) and the Pan-American Association of Infectious Diseases (API)
Authors: Barbosa Alexandre Naime , Chebabo Alberto , Starling Carlos , Pérez Clevy , Cunha Clóvis Arns , de Luna David , Nunes Estevão Portela , Zambrano Gabriela , Ferreira Juliana Carvalho , Croda Júlio , Falavigna Maicon , Silva Monica Maria Gomes da , Thormann Monica , Cimerman Sergio , Parahiba Suena Medeiros , Tanni Suzana , Bernardo Wanderley Marques , Rodriguez-Morales Alfonso J. 
Published: February 2023

Abstract

Background
Since the beginning of the COVID-19 pandemic, therapeutic options for treating COVID-19 have been investigated at different stages of clinical manifestations. Considering the particular impact of COVID-19 in the Americas, this document aims to present recommendations for the pharmacological treatment of COVID-19 specific to this population.
Method
Fifteen experts, members of the Brazilian Society of Infectious Diseases (SBI) and the Pan-American Association of Infectious Diseases (API) make up the panel responsible for developing this guideline. Questions were formulated regarding prophylaxis and treatment of COVID-19 in outpatient and inpatient settings. The outcomes considered in decision-making were mortality, hospitalisation, need for mechanical ventilation, symptomatic COVID-19 episodes, and adverse events. In addition, a systematic review of randomised controlled trials was conducted. The quality of evidence assessment and guideline development process followed the GRADE system.
Results
Nine technologies were evaluated, and ten recommendations were made, including the use of tixagevimab + cilgavimab in the prophylaxis of COVID-19, tixagevimab + cilgavimab, molnupiravir, nirmatrelvir + ritonavir, and remdesivir in the treatment of outpatients, and remdesivir, baricitinib, and tocilizumab in the treatment of hospitalised patients with severe COVID-19. The use of hydroxychloroquine or chloroquine and ivermectin was discouraged.
Conclusion
This guideline provides recommendations for treating patients in the Americas following the principles of evidence-based medicine. The recommendations present a set of drugs that have proven effective in the prophylaxis and treatment of COVID-19, emphasising the strong recommendation for the use of nirmatrelvir/ritonavir in outpatients as the lack of benefit from the use of hydroxychloroquine and ivermectin.
Effects of Zr, Al, and Mordenite on Pt-MCM-48 catalyst in n-heptane isomerization: Preparation, characterization and catalytic performance
Authors: Ghaderi Z. , Peyrovi M. H. , Parsafard N. 
Published: February 2023

Abstract
Herein, platinum loaded on various catalysts, MCM-48-Mordenite, Al-MCM-48, Al-MCM-48-Mordenite, Zr-MCM-48, and Zr-MCM-48-Mordenite has been synthesized and investigated for n-heptane isomerization reaction at four different temperatures. The XRD, FT-IR, UV-Vis DRS, NH3-TPD, and BET analysis characterized the structural characterization and acid distribution of these catalysts. The Pt/Mordenite catalyst showed higher hydrogenation and cracking activity while the hybrid catalysts showed better isomerization selectivity. The best catalytic behavior was obtained by Pt/Al-MCM-48-Mordenite catalyst at 200°C, with suitable n-heptane conversion (78.8%) and the highest isomer selectivity (81.9%). The maximum isomerization selectivity as well as the maximum yield of multi branched isomers probably not only due to its suitable acidity and large pores but also due to higher metal dispersion. This result indicates that the Pt/Al-MCM-48-Mordenite catalyst can be a hopeful candidate for good n-heptane isomerization catalysts.
The impact of sleep quality on mental health in working Australians: A quasi-experimental approach
Authors: Foo Jia Kai , Doan Tinh 
Published: February 2023

Abstract
Work conditions and major life events can impact individual sleep quality, and subsequently impact mental health. This study aims to investigate effect of sleep quality on mental health of working Australians. We pioneer to employ a novel method in public health studies, a quasi-experimental (Instrumental Variable) approach, which can address reciprocal relationships between sleep and mental health in order to estimate causal effect of sleep quality on mental health on a sample of 14,480 working Australians aged 25-64 from the Household, Income and Labour Dynamics in Australia (HILDA) survey waves 2013 and 2017. We find that work conditions such as high job demand, long workhours, long unpaid workhours, shift work, and major life events adversely affect sleep quality, and hence the changes in sleep quality strongly affect mental health of working Australians. The finding underscores the need for policies that should address current employment conditions by reducing long workhours, high work demand, irregular work shifts, and providing better support including emotional support programs, and creating worker-friendly settings to mitigate poor sleep quality in the Australian workforce. Doing so would help improve workers’ sleep quality, and ultimately mental health and overall health outcomes.
Risk factors for breast cancer in mammography consultation at hospital of Ecuador, 2020.
Authors: Meyra Mieles Resabala Rosa , Poveda Mildred Valeria Pico , Pérez Alfredo Marín , Cedillo-Balcázar Jamil 
Published: February 2023

Abstract
Breast cancer is the most commonly diagnosed cancer among women in the western hemisphere and represents the cancer with the highest incidence in the female population of Ecuador and the predisposition to develop breast cancer responds to several factors.
Objective: To determine the risk factors for breast cancer in patients of the mammography office of the Dr. Verdi Cevallos Regional Hospital.
Methods: Observational, descriptive and cross-sectional research, with a sample of 143 women who attended the mammography consultation of the Regional Hospital Dr. Verdi Cevallos Balda during the period January-December 2020, through the application of a 22-question questionnaire on risk factors for breast cancer, prepared by specialists in the area.
Results: The most significant risk factors in the study were: family history of cancer, not breastfeeding, early menarche and hormone replacement therapy.
Conclusion: It was observed that the risk factors for breast cancer in order of importance are: family history of cancer, early menarche, not breastfeeding, and hormone replacement therapy.
Leakage detection in water distribution networks using machine-learning strategies
Authors: Sousa Diego Perdigão , Du Rong , Mairton Barros da Silva Jr José , Cavalcante Charles Casimiro , Fischione Carlo 
Published: February 2023

AbstractThis work proposes a reliable leakage detection methodology for water distribution networks (WDNs) using machine-learning strategies. Our solution aims at detecting leakage in WDNs using efficient machine-learning strategies. We analyze pressure measurements from pumps in district metered areas (DMAs) in Stockholm, Sweden, where we consider a residential DMA of the water distribution network. Our proposed methodology uses learning strategies from unsupervised learning (K-means and cluster validation techniques), and supervised learning (learning vector quantization algorithms). The learning strategies we propose have low complexity, and the numerical experiments show the potential of using machine-learning strategies in leakage detection for monitored WDNs. Specifically, our experiments show that the proposed learning strategies are able to obtain correct classification rates up to 93.98%.
The Recent Developments of ADCs with the Tubulysins as the Payloads
Authors: Xiangrong Xu , Yao Lei , Yao Angela 
Published: February 2023

Abstract:
As a novel bio-targeting antitumor agent, an antibody-drug conjugate (ADC) combines the
high selectivity of monoclonal antibody and potent cytotoxicity of drug or payload. It can expand the
scope of clinical application of small molecule drugs. Tubulysin and its bio-precursor pretubulysin
(PT) are potent tubulin-binding antitumor drugs. Due to the excellent antitumoral, antimetastatic, antiangiogenic,
and anti-multidrug resistance properties, Tubulysins or PT is believed to be a promising
cancer therapeutic approach. Currently, the modifications of tubulysin are centering on the C-11 acetoxyl
and N,O-acetal groups, and numerous promising payloads are identified. There are at least 5
sites to introduce appropriate drug linkers in tubulysin and PT for connecting the antibodies. The possible
sites of attachment are located in Mep, Tuv, or Tup parts. Cleavage and non-cleavage linkers are
used in these ADCs. The chemical reactions involved in the final conjugation of antibody and linkerpayload
(LP) are cysteine, lysine, site-specific, and click chemistry reactions. In this article, the recent
development of ADCs with tubulysins as the payloads is reviewed, with the hope of providing a
reference and future strategies for developing new ADSs.
The Influence of a Wearable-Based Reward Program on Health Care Costs: Retrospective, Propensity Score–Matched Cohort Study
Authors: Zaleski Amanda , Sigler Brittany , Leggitt Alan , Choudhary Shruti , Berns Ryan , Rhee Kyu , Schwarzwald Heidi 
Published: February 2023

Background
Mobile health (mHealth) technology holds great promise as an easily accessible and effective solution to improve population health at scale. Despite the abundance of mHealth offerings, only a minority are grounded in evidence-based practice, whereas even fewer have line of sight into population-level health care spending, limiting the clinical utility of such tools.

Objective
This study aimed to explore the influence of a health plan–sponsored, wearable-based, and reward-driven digital health intervention (DHI) on health care spending over 1 year. The DHI was delivered through a smartphone-based mHealth app available only to members of a large commercial health plan and leveraged a combination of behavioral economics, user-generated sensor data from the connected wearable device, and claims history to create personalized, evidence-based recommendations for each user.

Methods
This study deployed a propensity score–matched, 2-group, and pre-post observational design. Adults (≥18 years of age) enrolled in a large, national commercial health plan and self-enlisted in the DHI for ≥7 months were allocated to the intervention group (n=56,816). Members who were eligible for the DHI but did not enlist were propensity score–matched to the comparison group (n=56,816). Average (and relative change from baseline) medical and pharmacy spending per user per month was computed for each member of the intervention and comparison groups during the pre- (ie, 12 months) and postenlistment (ie, 7-12 months) periods using claims data.

Results
Baseline characteristics and medical spending were similar between groups (P=.89). On average, the total included sample population (N=113,632) consisted of young to middle-age (mean age 38.81 years), mostly White (n=55,562, 48.90%), male (n=46,731, 41.12%) and female (n=66,482, 58.51%) participants. Compared to a propensity score–matched cohort, DHI users demonstrated approximately US $10 per user per month lower average medical spending (P=.02) with a concomitant increase in preventive care activities and decrease in nonemergent emergency department admissions. These savings translated to approximately US $6.8 million in avoidable health care costs over the course of 1 year.

Conclusions
This employer-sponsored, digital health engagement program has a high likelihood for return on investment within 1 year owing to clinically meaningful changes in health-seeking behaviors and downstream medical cost savings. Future research should aim to elucidate health behavior–related mechanisms in support of these findings and continue to explore novel strategies to ensure equitable access of DHIs to underserved populations that stand to benefit the most.
Perencanaan Sistem Loop Jaringan 20 kV Menggunakan Load Breaking Switch Motorized di Penyulang Sawit, Jati dan Pala
Authors: Fitriono Fitriono , D Dasweptia , H Hamimi 
Published: February 2023

ABSTRAK
Perencanaan Sistem Loop Jaringan 20 kV Menggunakan LBS (Load Breaking Switch Motorized) di PenyulangSawit, Jati dan Pala. Program Studi Teknik Elektro Fakultas Teknik Universitas Muhammadiyah Lampung.
Setiap jaringan tegangan menengah 20 kV termasuk jaringan penyulang Sawit, Jati dan Pala pasti akan mengalami pemadaman untuk proses pemeliharaan secara berkala, selain itu dengan kondisi jaringan yang relatif panjang yaitu penyulang Sawit 78,4 KMS, penyulang Jati 45,8 KMS dan penyulang Pala 130,1 KMS maka potensi akan terjadi gangguan pada jaringan penyulang Sawit, Jati dan Pala cukup tinggi. Berdasarkan kondisi pemeliharaan dan potensi gangguan yang akan terjadi serta konfigurasi jaringan eksisting yang tidak memungkinkan untuk dimanuver maka penyaluran energi listrik ke pelanggan menjadi tidak handal.
Untuk mendapatkan jaringan tegangan menengah yang handal tentunya perlu dilakukan analisis, evaluasi dan simulasi kehandalan jaringan dalam menghadapi kondisi-kondisi pemeliharaan dan gangguan. Karena tingginya ENS (Energy Not Supplied) yang ditimbulkan pada simulasi kondisi eksisting maka dilakukan perencanaan pemasangan LBSM pada titik manuver penyulang atau titik pertemuan penyulang yaitu LBSM Dono Mulyo (pertemuan penyulang Sawit dan Pala) dan LBSM BD 8 (pertemuan penyulang Jati dan Pala), selain itu untuk mempercepat waktu pengusutan gangguan maka juga dilakukan resetting dan pengaktifan fungsi sectionalizer pada LBSM yang menjadi pembatas setiap section di penyulang.
Sistem Informasi Berbasis Web Untuk Memonitoring Perangkat Internet of Things (IoT) Menggunakan Node-Red
Authors: Mulyawan M Fikri , Batubara Mona Arif Muda , Pradipta Rio Ariestia 
Published: February 2023

Information systems in monitoring Internet of Things (IoT) devices in this advanced telecommunications world are very important, where we can see in real-time the data displayed by the device. This is very useful in improving the performance and efficiency of the development party. The use of this technology makes it easier to anticipate error that occurs to system Internet of Things (IoT) devices. By being displayed using a dashboard, it makes it easier for users to read data provided by the Internet of Things devices.
In this study, the author develops a Dashboard information system for the Internet of Things Device system. Data from the system will be sent to a database which will then be displayed using the Node-Red tools. This tool is a middleware that connects the Internet of Things (IoT) devices with a database, the results of reading the Internet of Things system will be stored in the database and the results can be seen through the Dashboard in real-time. The result of the measurement if it exceeds the standard limit that has been determined, will give an alert in the form of a notification in the Email.
Pendidikan Karakter Anak Usia Dini untuk Melatih Kendirian Melalui Bermain Bahan Alam
Authors: Prifiantari Siska 
Published: February 2023

The decline in the morals of the millennial generation, an era that is increasingly rampant with technological sophistication in the era of globalization has made a retreat in the moral quality of life of the Indonesian people today, especially among students and demands character education. This research uses the library research method. Data collection techniques are obtained from 11 kinds of journal articles related to the topic of discussion. It is very important to form the character of the child from an early age. A strong identity and character really need a systematic and well-organized coaching program. Child character education is not only carried out by the teacher, but the main task of parents is also to implement the child's character education at home. In carrying out character education, parents and teachers are role models to imitate and follow. Independence is the ability of the child to do everything independently, both related to his own activities and in everyday life, without being completely dependent on others. With the attitude of independence that the child has provides enormous benefits for himself including, 1) Children can move more freely to learn and interact with the surrounding environment; 2) Make them more confident and make things free; 3) Children are easy to play and interact well; 4) Easy to work and communicate with the child
Pelaksanaan Pendidikan Karakter di SMPN 3 Pariaman
Authors: Oktavia Aini Anisa , Eldarni Eldarni 
Published: February 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan pendidikan karakter di SMPN 3 Pariaman serta mengetahui kendala-kendala dan upaya yang dilakukan guru dalam pelaksanaan pendidikan karakter. Pendidikan karakter yang dibangun dalam kegiatan sekolah merupakan salah satu program strategis yang diharapkan dapat mengatasi berbagai permasalahan yang berkaitan dengan moral siswa. Jenis penelitian ini menggunakan penelitian kuantitatif deskriptif. Populasi yang diambil adalah guru SMPN 3 Pariaman. Sampel penelitiannya sebanyak 45 guru. Instrumen pengumpulan data menggunakan angket (kuisioner). Hasil penelitian dianalisis menggunakan presesentase. Penelitian menyimpulkan bahwa: (1) pelaksanaan pendidikan karakter di SMPN 3 Pariaman sudah dilaksanakan dengan kategori “Sangat Baik” dengan hasil rata-rata 91,20%; (2) kendala-kendala dalam pelaksanaan pendidikan karakter berada pada kategori “Tinggi” dengan rata-rata 71,38%; (3) upaya yang dilakukan guru untuk mengatasi hambatan tersebut berada pada kategori “Sangat Baik” dengan rata-rata 85,78%
KEMAMPUAN KONEKSI MATEMATIS SISWA PADA MODEL PEMBELAJARAN CONNETED MATHEMATICS PROJECT (CMP)
Authors: Puteri Junike Wulandari , Riwayati Selvi 
Published: February 2023

Tujuan penelitian ini mengetahui apakah ada perbedaan kemampuan koneksi matematis siswa menggunakan model pembelajaran CMP dan pembelajaran konvensional. Salah satu tujuan matematika adalah kemampuan menjelaskan keterkaitan antar konsep matematika. Oleh karena itu, kemampuan koneksi matematis peting dalam proses pembelajaran. Salah satu alternatif model pembelajaran untuk menumbuh kembangkan kemampuan koneksi matematis siswa adalah dengan memilih model pembelajaran CMP. Pada proses pembelajaran CMP dilakukan dengan berkelompok dimana siswa akan dituntut untuk bisa menghubungkan materi yang sudah di pelajari dengan materi yang akan dipelajari. Jenis penelitian ini adalah penelitian eksperimen semu. Adapun populasi dalam penelitian ini adalah semua siswa kelas VIII SMP N 15 Kota Bengkulu yang terdiri dari 5 kelas. Setelah diambil secara acak terpilih kelas VIII D sebagai kelas kontrol dan VIII E sebagai kelas eksprimen. Instrument penelitian ini adalah tes kemampuan koneksi matematis berupa pretest-posttest dalam bentuk soal uraian. Dalam penelitian ini teknik analisis data menggunakan uji t. Hasil penelitian menunjukkan bahwa kemampuan koneksi matematis siswa yang diajar menggunakan model pembelajaran CMP lebih baik dibandingkan dengan pembelajaran konvensional.
SEMIGRUP SMARANDACHE (L_D (V,W),Θ)
Authors: Rahmawati Miftah Sigit 
Published: February 2023

Semigrup merupakan struktur aljabar yang merupakan perumuman dari grup. Suatu semigrup yang memuat suatu subset sejati sedemikian hingga subset tersebut merupakan grup terhadap operasi biner yang sama pada semigrup disebut semigrup Smarandache. Himpunan semua transformasi linear dari suatu ruang vektor V ke ruang vektor V, yaitu LD(V) terhadap operasi komposisi transformasi linear membentuk suatu semigrup. Apabila diberikan himpunan transformasi linear dari suatu ruang vektor V ke ruang vektor W, yaitu LD(V,W) maka LD(V,W) bukan merupakan semigrup terhadap operasi komposisi transformasi linear. Himpunan transformasi linear LD(V,W) dapat menjadi suatu semigrup terhadap operasi komposisi transformasi linear dengan membantuk semigrup transformasi linear yang diperumum. Dalam tulisan ini akan dibahas mengenai regularitas dan unit-regularitas dari suatu semigrup transformasi linear yang diperumum tersebut. Selanjutnya, juga dibahas mengenai karakterisasi dan beberapa sifat dari semigrup Smarandache dan hubungannya dengan semigrup transformasi linear yang diperumum. Hubungan tersebut meliputi syarat perlu dan syarat cukup agar suatu semigrup transformasi linear menjadi semigrup Smarandache.
PENGARUH PEMANFAATAN ALAM SEKITAR DALAM MENINGKATKAN MOTIVASI BELAJAR SISWA PADA PEMBELAJARAN IPA DI SD
Authors: Kusumawardani Siska , Santi Apri Utami Parta , Pratiwi Dwi Lenggo 
Published: February 2023

Penelitian ini di latar belakangi dengan rendahnya motivasi siswa dalam pembelajaran IPA, permasalahan ini dikarenakan guru yang masih menggunakan metode ceramah pada saat kegiatan pembelajaran IPA berlangsung. Sehingga penulis tergerak untuk meneliti sambil memberikan solusi dengan menerapkan pendekatan alam sekitar. Adapun tujuan penelitian ini untuk menumbuhkan motivasi belajar siswa melalui pemanfaatkan alam disekitar. Metode yang digunakan menggunakan metode penelitian eksperimen dengan pendekatan posttest-only control design. Hasil penelitian menunjukkan bahwa terdapat pengaruh pemanfaatan alam sekitar dalam meningkatkan motivasi belajar siswa pada pembelajaran IPA. Hal ini terbukti dari hasil perhitungan uji t telah diketahui nilai t hitung sebesar 3,936 > 1.690 serta nilai signifikansinya sebesar 0,000 bahwa nilai signifikansinya < 0,05. Kemudian dilihat dari hasil R-Square bahwa terdapat pengaruh sebesarh 8,5%. Hasil penelitian ini diharapkan dapat bermanfaat kepada pihak-pihak terkait. . Kata kunci: Pemanfaatan Alam Sekitar, Motivasi Belajar, Pembelajaran IPA
POLA KOMUNIKASI DIGITAL PERUSAHAAN NASIONAL DAN MULTINASIONAL SELAMA PANDEMI COVID-19
Authors: Hidayat Mochamad Taufiq 
Published: February 2023

Selama pandemi Covid-19 banyak perusahaan nasional dan multinasioal menerapkan pembatasan kerja denan menerapkan work from home. Salah satu konsekuensinya akan membuat komunikasi dalam organisasi mengunakan aplikasi dan platform digital. Penelitian ini ditujukan untuk menggambarkan pola komunikasi dalam organisasi yang dilakukan melalui aplikasi atau platform digital. Penelitian ini difokuskan untuk menjelaskan pola komunikasi internal yang berlangsung dalam perusahaan. Dengan menggunakan pendekatan studi kasus, penelitian dilakukan di PT BHL perusahan nasional dan PT II perusahaan multinasional. Selain wawancara dan pengamatan, juga dilakukan penelusuran sumber sekunder berupa catatan aktivitas komunikasi dalam organisasi. Hasil penelitian menunjukkan bahwa pola komunikasi yang digunakan di perusahaan nasional dan multinasional yaitu semua saluran atau bintang. Faktor yang menjadi pendukung ialah Hubungan yang personal, dan fleksibilitas. Secara praktis, efektifitas berkomunikasi pola bintang bisa membawa fleksibelitas yang dijalankan dapat membuat kinerja karyawan lebih baik.