bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolactin in headache and migraine: A systematic review of preclinical studies
Authors: Al‐Karagholi Mohammad Al‐Mahdi , Kalatharan Veberka , Ghanizada Hashmat , Dussor Gregory , Ashina Messoud 
Published: February 2023

AbstractObjectiveTo systemically review preclinical studies investigating the implication of prolactin signaling in headache and migraine pathophysiology.BackgroundThe features of migraine attacks, including characteristics, duration, frequency, and prevalence, are sex‐dependent with variability across a lifetime, indicating the involvement of the hypothalamus‐pituitary‐gonadal axis. Prolactin is a key regulator of this axis, and a new line of evidence implicates prolactin signaling in sex‐related differences in pain perception.MethodsIn this systematic review, we searched PubMed and EMBASE for the terms prolactin, hyperprolactinemia, macroprolactinemia, hypoprolactinemia, migraine, headache, head pain, and trigeminal pain pathway to find preclinical studies investigating prolactin signaling in headache and migraine. Two reviewers independently screened 841 articles for population, intervention, comparison, outcome, and study design. Studies were restricted to the English language and were excluded if they had a nonexperimental methodology.ResultsOf a total of 15 preclinical articles selected, 11 were both ex vivo and in vivo, 3 were ex vivo, and 1 was an in vivo study. The main findings were that prolactin receptors are distributed in the trigeminal pain pathway, and prolactin induced migraine‐like behavior in rodents. Moreover, prolactin signaling has a crucial role in calcitonin gene–related peptide (CGRP) release, a key molecule in migraine pathogenesis, and prolactin gene deletion attenuated CGRP‐induced migraine‐like behavior.ConclusionPreclinical data indicate a key role of prolactin and its receptors in mechanisms causing migraine. Further randomized and placebo‐controlled clinical studies targeting prolactin signaling are needed to further clarify the influences of prolactin in migraine‐attack initiation.
New regimens as first‐line eradication therapy for Helicobacter pylori infection in patients allergic to penicillin: A randomized controlled trial
Authors: Zhang Yuxin , Suo Baojun , Tian Xueli , Zhang Hua , Lu Haoping , Yao Xingyu , Li Cailing , Ren Xinlu , Zhou Liya , Song Zhiqiang 
Published: February 2023

AbstractBackgroundHelicobacter pylori eradication in penicillin‐allergic patients is challenging. The effective regimen is lacking in areas with high antibiotic resistance and tetracycline unavailable. Minocycline, cefuroxime, and full‐dose metronidazole are promising drugs.AimsTo compare the eradication rate, safety, and compliance among three new bismuth quadruple therapies for first‐line H. pylori eradication in penicillin‐allergic patients.MethodsThis randomized trial was conducted on 450 naive patients with H. pylori infection and penicillin allergy. The 14‐day minocycline‐metronidazole‐containing (minocycline 100 mg twice daily and metronidazole 400 mg four times/day), minocycline‐cefuroxime‐containing (minocycline 100 mg twice daily and cefuroxime 500 mg twice daily), and cefuroxime‐metronidazole‐containing (cefuroxime 500 mg twice daily and metronidazole 400 mg four times/day) bismuth quadruple therapies were randomly assigned to the participants. Safety and compliance were assessed within 3 days after eradication. Urea breath test was performed 4–8 weeks after eradication to evaluate outcome.ResultsThe differences of eradication rates in either intention‐to‐treat (84.0%, 82.7%, and 23 82.0%, p = .896) or per‐protocol (91.7%, 90.9%, and 88.2%, p = .599) analysis among minocycline‐metronidazole, minocycline‐cefuroxime, and cefuroxime‐metronidazole‐containing bismuth quadruple therapies were statistically insignificant. The incidence of adverse events (35.1%, 22.6%, and 28.9%) and compliance (90.5%, 91.8%, and 91.9%) were similar. Taste distortion, nausea, and anorexia were more common in metronidazole‐containing regimens, and dizziness was more common in minocycline‐containing regimens. The allergy was rare (~3%).ConclusionsThe efficacies of three bismuth quadruple therapies containing minocycline, cefuroxime, and full‐dose metronidazole (pairwise) for first‐line H. pylori eradication in penicillin‐allergic patients were similarly satisfactory with relatively good safety and compliance. The study was registered in the Chinese Clinical Trials Registration (ChiCTR1900023702).
Ion beam assisted electron beam vacuum deposition of antireflective SiO2coating on MgAl2O4spinel
Authors: Meng Xiaomin , Peng Bo , Yao Longjiao , Wang Yadong , Feng Shuang , Ge Qi , Shaker Majid 
Published: February 2023

AbstractIn this paper, the electron beam vacuum coating method was used to coat a SiO2film on an MgAl2O4spinel substrate. The thickness of the coating was aimed to be 925 nm based on the physics of the antireflection coatings. Atomic force microscope images revealed that the coated silica was 880 nm thick, which is close to the aimed theoretical thickness and had 2.11 nm roughness. It could enhance the transparency of the spinel substrate by being coated on it. The infrared transmittance of the sample coated with SiO2film in the range of 3700 nm‐4800 nm was measured by a Fourier transform infrared spectrometer and reached 92.5% to 78.5%, which was about 2%–4% higher than that of MgAl2O4spinel. In addition, it was discovered that the bonding force between the coating and the substrate is determined to be about 200 MPa. The results of this study can be used for further precise design and production of antireflection coatings on the transparent materials that need more transparency.
Consumers' willingness to pay for corporate social responsibility: Theory and evidence
Authors: Narayanan Sajith , Singh Guru Ashish 
Published: February 2023

AbstractIn an era when consumers believe that businesses should engage in corporate social responsibility (CSR), it is vital to understand how it affects consumers' willingness to pay (WTP) for the goods and services offered by such businesses. There is a need for an in‐depth study into the relationship between CSR and WTP, and to identify the mediators and the moderators affecting this relationship. To investigate this, we conducted a systematic literature review based on a preliminary search result of 116 unique articles indexed on this topic in four bibliographic databases—Scopus, Google Scholar, Dimensions and Web of Science—published over the previous seven decades. The findings confirm the overall positive effect of CSR on WTP. This study also reveals the indirect effect between CSR and WTP, mediated by variables like Brand Trust, Brand Loyalty, Brand Love, Customer Satisfaction, Brand Attitude, Purchase Intention and Brand Equity. The relationship is impacted by moderators, including demographics, cause‐based aspects, company characteristics, personal aspects and types of products. The theory explaining the evidence of each of these aspects provides a deeper understanding of the relationship between CSR and WTP, and the intervening variables. Based on these, a conceptual framework of this relationship involving all the variables is developed. The Theory, Context and Method (TCM) framework is employed to identify gaps and systematically make recommendations for future research. The findings of this study will aid marketers in developing pricing strategies based on a thorough understanding of consumer behaviour in terms of CSR perceptions. Scholars can use this study's conceptual framework to examine previously unexplored relationships. As the literature on CSR and its influence on consumers' purchase behaviour grows, this comprehensive systematic literature review on the effects of CSR on WTP fills an important gap.
Iron deficiency in nonanaemic COPD patients—Could Low haemoglobin density and Microcytic anaemia factor be usefull?
Authors: Trtica Marko , Milenković Branislava , Janković Jelena , Janjić Sanja Dimić , Pantić Vesna Dopuđa , Dopsaj Violeta 
Published: February 2023

AbstractIntroductionErythrocyte indices LHD and Maf are complementary parameters to complete blood count and have been shown as reliable iron deficiency markers in different clinical settings. The aim of the study was to assess diagnostic performances of LHD and Maf in detecting iron deficiency in nonanaemic stable COPD patients.MethodsA total of 93 nonanaemic stable COPD patients were classified as either iron deficient (ID, N = 15) or non‐iron deficient (non‐ID, N = 78). Iron deficiency was defined as a ferritin level < 100 μg/L with a transferrin saturation (TSAT) <20%. A complete blood count, including LHD and Maf as well as other relevant inflammation and iron status parameters were obtained for all participants.ResultsBoth LHD and Maf have shown significant differences between the ID and non‐ID group with p = .003 and p = .007 respectively. The AUC for LHD was .744 (95% CI: .626–.863, p = .003) with the best cut‐off of 5.85 and sensitivity of 80% (95% CI: 76.0–84.0) and specificity of 61.5% (95% CI: 58.4–64.6). The AUC for Maf was .707 with optimal cut‐off value 12.65 and sensitivity of 83.3% (95% CI: 79.1–87.5) and specificity of 60.0% (95% CI: 57.0–63.0). Furthermore, LHD performance was not affected by vitamin B12 status.ConclusionLHD and Maf are useful for iron deficiency diagnosis in stable COPD patients. LHD was shown to be resistant to vitamin B12 deficiency, which is of substantial importance in specific patient subpopulations. Both parameters are not technology‐dependant and do not require additional sample and/or reagent volume, which makes them cost‐effective and convenient for everyday use.
The prospects of judicial social work for incapacitated older adults: Evidence on how Chinese social workers may contribute
Authors: Wang Yixuan , Guo Junjie , Gao Siyu , Wang Yucong , Liu Qi , Liu Jinnan , Zhou Xiaochun 
Published: February 2023

AbstractWith the increasing aging of the Chinese population, the issue of safeguarding the welfare of older adults has emerged in social governance. Currently, the primary strategy to address this issue is the guardianship system, which is plagued with various challenges in judicial practice. Through two consecutive and contingent studies, for the first time, this research investigated the status quo of China's guardianship disputes involving older adult wards, analysed the missing role of social workers during the civil litigation process of these disputes, and identified the subtypes of disputes to which judicial social work could contribute. In the first study, 12 members of a district court of Shanghai who have dealt with such disputes were interviewed to explore the potential roles of social workers. Findings highlight the prospects of social workers serving as assessors and conveners during court hearings, supervisors and moderators after the court hearing, and facilitators and carers throughout the litigation process. In the second study, 16 cases of guardianship disputes involving incapacitated older adult wards were extracted from this court through systematic sampling and processed with crisp‐set qualitative comparative analysis. Findings reveal the types of cases in which social workers should intervene. This article advocates for involving professionally trained social workers in China's civil court setting to safeguard incapacitated older adults' welfare further.
Postoperative symptom management perceptions and coping experiences of individuals with prostate cancer
Authors: Kazımoğlu Hatem , Ulutaşdemir Nilgün , Kulakaç Nurşen , Uzun Sevda 
Published: February 2023

AbstractObjectiveThis study aims to examine in depth the perceptions of postoperative symptom management and coping experiences of individuals with prostate cancer.Material‐MethodThe study was conducted with 15 individuals with prostate cancer using a phenomenological research design, which is a qualitative research design. Interviews were conducted via the WhatsApp application.ResultsThe data were analysed using Colaizzi's phenomenological method. In the data analysis, two categories, five main themes, and 15 sub‐themes emerged. In the category of symptom management perception, there are themes of pain management processes, the use of complementary and alternative therapies and practices to cope with symptoms and improve quality of life. In the category of coping experiences, the themes of individual coping, interpersonal relations, and productivity were obtained.ConclusionOur study suggests that individuals with prostate cancer have difficulty in symptom management in the postoperative coping process, but they managed them effectively with the support of their spouse, family, and health care professionals.
ASPP2 suppresses tumour growth and stemness characteristics in HCC by inhibiting Warburg effect via WNT/β‐catenin/HK2 axis
Authors: Liang Beibei , Jiang Yuan , Song Shaohua , Jing Wei , Yang Hao , Zhao Li , Chen Ya , Tang Qiqi , Li Xuhui , Zhang Lisha , Bao Haili , Huang Gang , Zhao Jian 
Published: February 2023

AbstractAbnormal energy metabolism is one of the characteristics of tumours. In the last few years, more and more attention is being paid to the role and regulation of tumour aerobic glycolysis. Cancer cells display enhanced aerobic glycolysis, also known as the Warburg effect, whereby tumour cells absorb glucose to produce a large amount of lactic acid and energy under aerobic conditions to favour tumour proliferation and metastasis. In this study, we report that the haploinsufficient tumour suppressor ASPP2, can inhibit HCC growth and stemness characteristics by regulating the Warburg effect through the WNT/β‐catenin pathway. we performed glucose uptake, lactate production, pyruvate production, ECAR and OCR assays to verify ASPP2 can inhibit glycolysis in HCC cells. The expression of ASPP2 and HK2 was significantly inversely correlated in 80 HCC tissues. Our study reveals downregulation of ASPP2 can promote the aerobic glycolysis metabolism pathway, increasing HCC proliferation, glycolysis metabolism, stemness and drug resistance. This ASPP2‐induced inhibition of glycolysis metabolism depends on the WNT/β‐catenin pathway. ASPP2‐regulated Warburg effect is associated with tumour progression and provides prognostic value. and suggest that may be promising as a new therapeutic strategy in HCC.
Quality of life and nurse–patient interaction among NH residents: Loneliness is detrimental, while nurse–patient interaction is fundamental
Authors: Kuven Britt Moene , Drageset Jorunn , Haugan Gørill 
Published: February 2023

AbstractAims and ObjectivesTo investigate the association between perceived nurse–patient interaction and quality‐of‐life among nursing home residents, adjusted for loneliness, anxiety and depression.BackgroundSymptoms of anxiety and depression are known to residents of nursing homes along with cognitive impairment, physical inactivity and low quality‐of‐life. Anxiety, depression and loneliness are found detrimental to NH residents' quality‐of‐life. The nurse–patient relationship is important for patient's well‐being, both in terms of illness and symptom management.DesignCross‐sectional design.MethodsData were collected in 2017 and 2018 from 188 residents in 27 nursing homes resided in two large urban municipalities in Middle and Western Norway. The inclusion criteria were: (1) local authority's decision of long‐term NH care; (2) residential stay 3 months or longer; (3) informed consent competency recognised by responsible doctor and nurse; (4) capable of being interviewed, and (5) aged 65 years or older. This article is executed in accordance with STROBE statement.ResultsAdjusting for age, sex, anxiety, depression and loneliness, perceived nurse–patient interaction was statistically significant to quality‐of‐life. While anxiety and depression showed insignificant estimates, loneliness demonstrated a significant relation with quality‐of‐life. Nurse–patient interaction and loneliness explained together 25% of the variation in quality‐of‐life.ConclusionThis study suggests that loneliness is frequent as well as more detrimental to quality‐of‐life among nursing home residents compared to anxiety and depression. Furthermore, the present results show that the nurse–patient interaction represents an essential health‐promoting resource for Quality‐of‐life in this population.Relevance to clinical practiceStaff nurses need to exercise their awareness of loneliness to meet residents' needs. Nursing educations should provide knowledge about nurse–patient interaction, and students as well as staff nurses in NHs should be trained, for instance by simulation, to use the nurse–patient interaction as a health‐promoting resource. Finally, loneliness represents a bigger challenge than depression and anxiety; accordingly, building nurses that are capable of meeting patients' needs and facilitate care that counteracts loneliness is highly warranted
Digital planning for two‐implant‐supported overdenture and bone reduction guide using cone‐beam computed tomography: Simple features for predictable outcomes
Authors: Meneghetti Priscila Ceolin , Sabri Hamoun , Dastouri Ebrahim , Pereira Rafael Martins Afonso , Teixeira Wendel , Wang Hom‐Lay , Mendonça Gustavo 
Published: February 2023

AbstractThe two‐implant‐supported mandibular overdenture is considered a reliable treatment option to restore masticatory function. Digital planning has been shown to improve the precision and accuracy of the surgical procedure. The outcomes are indeed pertinent to the ideal three‐dimentional positioning of the implant placement. Recently, the uses of cone‐beam computed tomography (CBCT) and intraoral scan have improved greatly the workflow of digital planning; however, the sophisticated technology caused confusion among clinicians. The purpose of this case series was to exhibit the efficacy of a bone‐supported guide in applying simultaneous implant placement and bone reduction, solely based on CBCT data. The bone reduction can therefore be determined accordingly, by adding windows to the guide, allowing the clinician to decide the amount of bone reduction as well as the location for implant placement. This novel surgical guide would not only fit properly on the bone but also provide the benefits of less‐invasive surgery and the opportunity to place implants parallel. The digital workflow described not only simplifies the fabrication process but also yields predictable surgical outcomes.
How do hospitalised children die? The context of death and end‐of‐life decision‐making
Authors: Serrano‐Pejenaute Idoya , Carmona‐Nunez Anabel , Zorrilla‐Sarriegui Ainhoa , Martin‐Irazabal Garazi , Lopez‐Bayon Julio , Sanchez‐Echaniz Jesus , Astigarraga Itziar 
Published: February 2023

AimThe decrease in childhood mortality, the growing clinical complexity and the greater technification of intensive care units have changed the circumstances of death of paediatric patients. The aim of this study is to describe the context of death and end‐of‐life decision‐making.MethodsSingle‐centre, retrospective, observational study of deaths in inpatients or home hospitalised children under 18 years old between 2011 and 2021. Demographic data, pathological history and circumstances of death were obtained from the medical record. The whole study period was divided into two halves for the analysis of the temporal trends.ResultsA total of 358 patients died, 63.2% under the age of 1 year old; 86.9% had underlying life‐limiting illnesses and 73.2% died in the intensive care unit, with no differences between the two time periods. Death at home was significantly higher in the second study period (3.8% vs. 9%). A total of 20.1% died during advanced cardiopulmonary resuscitation. Life‐sustaining treatment was withheld or withdrawn in 53.6%, with no differences between the time courses. Life‐sustaining treatment was withheld mainly in patients with neurological, metabolic and oncological conditions, and less frequently in patients with cardiovascular or respiratory diseases or who were previously healthy. Most patients coded as palliative care (PC) or followed up by PC teams had an advance care plan (ACP) recorded, while in the others it was infrequent. PC coding, following by PC teams and ACP recording increased in the last years of the study.ConclusionsDeath of children in our setting usually occurs in relation to complex underlying pathology and after the decision of withdrawing or withholding life‐sustaining treatment. In this context, PC and ACP acquire greater importance. In our study, PC involvement resulted in better documentation of ACP and PC coding.
Correlates of chronic hepatitis B virus infection in the general adult population of China: Systematic review and meta‐analysis
Authors: Hamilton Elizabeth Mova , Rassam Wadie , Yan Yan , Singh Avjit , Ng Sarah Yoon Ai , Zhang Jiabi , Lv Jun , Islam Nazrul , Malouf Reem , Yang Ling , Millwood Iona Y. , Chen Zhengming 
Published: February 2023

AbstractChronic infection with hepatitis B virus (HBV) is a significant public health issue in China. Understanding factors associated with chronic HBV is important to enable targeted screening and education and to improve early diagnosis and prevention of disease progression. This systematic review and meta‐analysis aimed to identify and describe correlates of chronic HBV among Chinese adults. Searches were conducted in MEDLINE, EMBASE and grey literature up to 25 June 2020. Eligible papers included observational studies in adults of the general population in China that reported factors associated with chronic HBV, measured by Hepatitis B surface antigen (HBsAg). Meta‐analysis was performed using fixed‐effect models of HBsAg prevalence among factors, and of adjusted odds ratios (ORs) for chronic HBV associated with each factor. Overall 39 articles were included, covering 22 factors, including a range of sociodemographic, behavioural and medical factors. In meta‐analysis of eligible studies, a range of factors were significantly associated with higher HBsAg prevalence, including middle age, male sex, being married, rural residence, lower education, smoking, having a HBsAg positive household contact, family history of HBV, history of surgery or blood transfusion. The adjusted ORs varied, from 1.11 (95% CI 1.05–1.18) for smoking to 5.13 (95% CI 4.99–5.26) for having a HBsAg positive household contact. In Chinese adults, a range of factors are associated with chronic HBV infection, which may help inform targeted screening in the general population.