bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of diabetes diagnosis on dental care utilization: evidence from Finland
Authors: Nurminen Mikko , Rättö Hanna 
Published: May 2023

Abstract
Background
Poor oral health is associated with many chronic diseases, including diabetes. As diabetes can worsen oral health and vice versa, care guidelines recommend that patients with diabetes maintain good oral health and have regular dental checkups. We analyzed the impact of receiving an initial type 2 diabetes diagnosis on dental care utilization.

Methods
We used register data on residents aged over 25 in the city of Oulu, Finland, covering the years 2013–2018. We used the difference-in-differences method and individuals with no diabetes diagnosis as control group. As robustness checks, we used propensity score matching and constructed an alternative control group from patients that received the same diagnosis a few years apart.

Results
Despite the guideline recommendations, we found that receiving a diabetes diagnosis did not increase the probability for dental care visits in a two-year follow-up. The findings remained similar for both high-income and low-income persons.

Conclusions
The finding is concerning in terms of diabetes management and oral health. Further research is needed on the reasons behind the lack of response to guidelines.
Innovation strategy design of public sports service governance based on cloud computing
Authors: Hao Yangyang , Qiu Zhaoyi , Xu Qiner , He Qiuhong , Fang Xuemo , Wang Chuyun 
Published: May 2023

AbstractPublic sports service is an important component of the modern government construction service system. They play an important role in strengthening the national physique, improving people’s satisfaction with public services, and improving people’s welfare. With the implementation of the national sports strategy, the quality of sports has continuously improved, and significant progress has been made in the construction of sports facilities, sports service mechanisms, sports service projects, and sports service personnel. Due to the inclination of national development centers and differences in regional economic levels, the effectiveness and implementation of public sports service governance may be affected. In order to solve the current problems of unbalanced development of public SS and insufficient social security, this article used cloud computing to conduct an innovative design for public SS governance and surveyed the satisfaction of residents in the community with public SS governance under the innovative design. Through comparative experiments, it studied the service quality and implementation effect of cloud computing on public SS governance. Through experimental analysis, it was found that the service quality and implementation effect of the public SS governance innovation strategy were higher than the original public SS service system. The service quality of the edge computing public SS innovation system was about 10.6% higher than the original public SS system, and the implementation effect was about 8.1% higher than the original public SS system. Experiments have verified the feasibility of sports service innovation strategies under cloud computing.
Filbertone, (2E)-5-methyl-2-hepten-4-one, regulates thermogenesis and lipid metabolism in skeletal muscle of a high-fat diet fed mice
Authors: Kim Hyemee , Ahn Byungyong 
Published: May 2023

AbstractFilbertone, the principal flavor compound of hazelnuts, is known to have preventive effects against hypothalamic inflammation, obesity and adipocity in vitro and in vivo. However, the effect of filbertone in skeletal muscle remains unknown. In the present study, we determined the effect of filbertone in skeletal muscle of mice fed a high-fat diet (HFD). To identify the underlying molecular and cellular processes of filbertone, we performed whole transcriptome sequencing in skeletal muscle. The muscle transcriptome analysis revealed that the upregulated differentially expressed genes (DEGs) in filbertone-fed mice were substantially associated with several pathways including thermogenesis, fatty acid degradation, oxidative phosphorylation, and branched chain amino acids (BCAAs) degradation. Furthermore, the expression level of thermogenic genes such as uncoupling protein 1 (Ucp1; p < 0.05), cell death-inducing DNA fragmentation factor alpha-like effector A (Cidea; p < 0.05), peroxisome proliferator-activated receptor alpha (Ppara; p < 0.05) and lipid droplet-associated protein genes such as Plin3 (p < 0.05), Plin4 (p < 0.05), and Plin5 (p < 0.05) were significantly upregulated in muscle tissue of HFD with filbertone fed mice compared to HFD only fed mice. Filbertone also elevated the protein level of UCP1 (p < 0.05) and PPARα (p < 0.05). In addition, filbertone reduced the accumulation of intracellular lipids in C2C12 myotubes (p < 0.05). On the basis of these results, we suggest that filbertone has a crucial effect in the regulation of muscle lipid metabolism and energy balance.
Emotional and external eating styles associated with obesity
Authors: Benbaibeche Hassiba , Saidi Hamza , Bounihi Abdenour , Koceir Elhadj Ahmed 
Published: May 2023

Abstract
Background
Obesity is related to eating habits. Overeating is the most behavioural trait implicated in obesity; emotional, external and rigid restrained eating are three maladaptive eating habits that are associated to overeating.

Objectives
The current study assesses the eating styles of Algerian adults. It identifies and analyses differences in eating styles in a sample from adults with normal BMI and who have obesity. The study examines the relationship between eating styles and BMI.

Methods
The sample consisted of 200 volunteers aged from 31 to 62 years old, 110 with obesity and 90 having normal BMI. The participants were recruited from hospital and university employees. They were questioned about their eating habits. The participants did not receive any treatment. To assess eating styles, participants completed the DEBQ.

Results
The prevalence of women was in the majority, representing 61% (n = 122) in the total sample (63.63% (n = 70) with obesity, and 55.77% (n = 52) with normal BMI). The prevalence of men represents 39% (n = 78) in the total sample (36.36% (n = 40) with obesity, and 42.22% (n = 38) with normal BMI). Participants with obesity showed pathological eating styles. They scored higher on emotional and external eating styles than to normal BMI group. However, restraint eating showed a slight no significant increase. The mean scores ± standard deviations observed in each eating styles were: emotional eating (2.88 ± 0.99** vs. 1.71 ± 0.32), external eating (3.31 ± 0.68** vs. 1.96 ± 0.29), and retrained eating (1.81 ± 0.7ns vs. 1.3 ± 0.30). The linear regression analysis showed an effect of emotional and external eating on BMI.

Conclusion
These results could be used to provide clinical information at the initial screening for obesity criteria, obesity prevention and treatment.
Cost-effective, rapid decorrelation stretching and responsive UAS mapping as a method of detecting archaeological sites and features
Authors: Potter Rich , Pitman Derek , Manley Harry , Rönnlund Robin 
Published: May 2023

Abstract
Approaches to aerial photography and remote sensing have become increasingly complex, can rely on opaque workflows, and have the potential to be published with inaccessible language. Conversely, aerial capture has become increasingly accessible with affordable, user-friendly unmanned aerial systems (UAS) now being commonplace in the field-archaeology toolkit. This means that considerable amounts of data are being produced by diverse projects, yet only a limited quantity are subject to advanced processing techniques. This paper aims to address this imbalance through a low-cost, accessible workflow that pairs frequent (multi-temporal) surveys with straightforward, out of the box processing. The results are comparable to more complex methodologies without the need to invest in expensive hardware (although a fast computer will make processing quicker) or abstract workflows. The detail and depth are still available if needed, but the aim is to make the interpretation of a wide range of imagery easier, rather than focus on the mechanics of the phenomena. The results demonstrate an effective, inexpensive and user-friendly workflow that requires only limited computational skills, but which offers robust, highly interpretable results.
Association of blood viscosity and device-free days among hospitalized patients with COVID-19
Authors: Waksman Ori , Choi Daein , Mar Phyu , Chen Qinzhong , Cho Daniel J. , Kim HyoungSup , Smith Robin L. , Goonewardena Sascha N. , Rosenson Robert S. 
Published: May 2023

Abstract
Background
Increased estimated whole blood viscosity (eWBV) predicts higher mortality in patients hospitalized for coronavirus disease 2019 (COVID-19). This study assesses whether eWBV is an early predictor of non-fatal outcomes among patients hospitalized for acute COVID-19 infection.

Methods
This retrospective cohort study included 9278 hospitalized COVID-19 patients diagnosed within 48 h of admission between February 27, 2020 to November 20, 2021 within the Mount Sinai Health System in New York City. Patients with missing values for major covariates, discharge information, and those who failed to meet the criteria for the non-Newtonian blood model were excluded. 5621 participants were included in the main analysis. Additional analyses were performed separately for 4352 participants who had measurements of white blood cell count, C-reactive protein and D-dimer. Participants were divided into quartiles based on estimated high-shear blood viscosity (eHSBV) and estimated low-shear blood viscosity (eLSBV). Blood viscosity was calculated using the Walburn–Schneck model. The primary outcome was evaluated as an ordinal scale indicating the number of days free of respiratory organ support through day 21, and those who died in-hospital were assigned a value of -1. Multivariate cumulative logistic regression was conducted to evaluate the association between quartiles of eWBV and events.

Results
Among 5621 participants, 3459 (61.5%) were male with mean age of 63.2 (SD 17.1) years. The linear modeling yielded an adjusted odds ratio (aOR) of 0.68 (95% CI 0.59–0.79, p value < 0.001) per 1 centipoise increase in eHSBV.

Conclusions
Among hospitalized patients with COVID-19, elevated eHSBV and eLSBV at presentation were associated with an increased need for respiratory organ support at 21 days. These findings are highly relevant, as they demonstrate the utility of eWBV in identifying hospitalized patients with acute COVID-19 infection at increased risk for non-fatal outcomes in early stages of the disease.
“Goals in Focus”—a targeted CBT approach for motivational negative symptoms of psychosis: study protocol for a randomized-controlled feasibility trial
Authors: Schormann Alisa L. A. , Pillny Matthias , Haß Katharina , Lincoln Tania M. 
Published: May 2023

Abstract
Background
The reduction of goal-directed behavior is the main characteristic in motivational negative symptoms of psychosis as it accounts for the long-term decline in psychological well-being and psychosocial functioning. However, the available treatment options are largely unspecific and show only small effects on motivational negative symptoms. Interventions that directly target the relevant psychological mechanisms are likely to be more effective. For “Goals in Focus”, we translated findings from basic clinical research on mechanisms underlying motivational negative symptoms into a tailored and comprehensive novel psychological outpatient treatment program. With this study, we will test the feasibility of the therapy manual and the trial procedures. We also aim to examine first estimates of the effect size that can be expected from “Goals in Focus” to inform the sample size calculation of a subsequent fully powered trial.

Methods
Thirty participants diagnosed with a schizophrenia spectrum disorder and at least moderate motivational negative symptoms will be randomly assigned to either 24 sessions of “Goals in Focus” over the course of 6 months (n = 15) or to a 6-month wait-list control group (n = 15). Single-blind assessments will be conducted at baseline (t0) and 6 months after baseline completion (t1). Feasibility outcomes include patient recruitment, retention, and attendance rates. Acceptability will be rated by trial therapists and by participants at end of treatment. Primary outcome for effect size estimation is the motivational negative symptom subscale sum score of the Brief Negative Symptom Scale at t1 corrected for baseline values. Secondary outcomes include psychosocial functioning, psychological well-being, depressive symptoms, expressive negative symptoms, negative symptom factor scores, and goal pursuit in everyday life.

Discussion
The feasibility and acceptability data will be used to improve trial procedures and the “Goals in Focus” intervention where necessary. The treatment effect on the primary outcome will provide the basis for the sample size calculation for a fully powered RCT.

Trial registration
1) ClinicalTrials.gov, NCT05252039. Registered on 23 February 2022.
2) Deutsches Register Klinischer Studien, DRKS00018083. Registered on 28 August 2019.
A checklist to guide the planning, designing, implementation, and evaluation of learning analytics dashboards
Authors: Kaliisa Rogers , Jivet Ioana , Prinsloo Paul 
Published: May 2023

AbstractHigher education institutions are moving to design and implement teacher-facing learning analytics (LA) dashboards with the hope that instructors can extract deep insights about student learning and make informed decisions to improve their teaching. While much attention has been paid to developing teacher-facing dashboards, less is known about how they are designed, implemented and evaluated. This paper presents a systematic literature review of existing studies reporting on teacher-facing LA dashboards. Out of the 1968 articles retrieved from several databases, 50 articles were included in the final analysis. Guided by several frameworks, articles were coded based on the following dimensions: purpose, theoretical grounding, stakeholder involvement, ethics and privacy, design, implementation, and evaluation criteria. The findings show that most dashboards are designed to increase teachers’ awareness but with limited actionable insights to allow intervention. Moreover, while teachers are involved in the design process, this is mainly at the exploratory/problem definition stage, with little input beyond this stage. Most dashboards were prescriptive, less customisable, and implicit about the theoretical constructs behind their designs. In addition, dashboards are deployed at prototype and pilot stages, and the evaluation is dominated by self-reports and users’ reactions with limited focus on changes to teaching and learning. Besides, only one study considered privacy as a design requirement. Based on the findings of the study and synthesis of existing literature, we propose a four-dimensional checklist for planning, designing, implementing and evaluating LA dashboards.
Optimization and characterization of exopolysaccharides from Leuconostoc citreum BH10 and its functional properties in vitro
Authors: Ge Zhiwen , Azi Fidelis , Bao Xuan , Yin Xintao , Feng Xue , Zhang Min , Xia Xiudong , Dong Mingsheng 
Published: May 2023

AbstractIn this study, the yield of exopolysacchrides (LCEPS) produced by Leuconostoc citreum BH10 was optimized through the improvement of fermentation conditions. A three-level four-factor central composite design coupled with response surface methodology was employed to elucidate the interactions among four design variables, namely fermentation time (X1), fermentation temperature (X2), sucrose concentration (X3), and inoculation amount (X4) over a broad range of process conditions and determine their effects on LCEPS production. Based on the developed models, under the optimum process conditions of 49.99 h, 25.59 °C, 21.66, and 3.00%, the obtained maximum production of LCEPS was up to 55.96 g/L. Besides, the produced LCEPS presented better thermal stability than the original dextran and rendered finely emulsifying properties compared with commercial emulsifiers. Moreover, the LCEPS possessed good antioxidant activities and showed certain biofilm inhibition against Staphylococcus aureus ATCC 6538 strain, which indicated that it has fine potential to be used as an excellent additive into the food industry.
Graphical Abstract
Does medial patellofemoral ligament reconstruction result in femoral tunnel enlargement? A systematic review
Authors: Abelleyra Lastoria Diego Agustín , Gopinath Vathana , Divekar Omkaar , Smith Toby , Roberts Tobias R. W. , Hing Caroline B. 
Published: May 2023

Abstract
Background
Medial patellofemoral ligament (MPFL) reconstruction is a common surgical procedure for treating patellar instability. The primary aim of this systematic review was to determine whether MPFL reconstruction (MPFLR) leads to femoral tunnel enlargement (FTE). The secondary aims were to explore the clinical effects and risk factors of FTE. Electronic databases (MEDLINE, Global Health, Embase), currently registered studies, conference proceedings and the reference lists of included studies were searched independently by three reviewers. There were no constraints based on language or publication status. Study quality assessment was conducted. 3824 records were screened in the initial search. Seven studies satisfied the inclusion criteria, evaluating 380 knees in 365 patients. Rates of FTE following MPFLR ranged from 38.7 to 77.1%. Five low quality studies reported FTE did not lead to detrimental clinical outcomes as assessed with the Tegner, Kujala, IKDC, and Lysholm scores. There is conflicting evidence regarding change in femoral tunnel width over time. Three studies (of which two had a high risk of bias) reported age, BMI, presence of trochlear dysplasia and tibial tubercle-tibial groove distance did not differ between patients with and without FTE, suggesting these are not risk factors for FTE.

Conclusion
FTE is a common postoperative event following MPFLR. It does not predispose poor clinical outcomes. Current evidence lacks the ability to identify its risk factors. The reliability of any conclusions drawn is hindered by the low level of evidence of the studies included in this review. Larger prospective studies with long-term follow up are required to reliably ascertain the clinical effects of FTE.
Surgical resection of micronodular thymic carcinoma with lymphoid hyperplasia: a case report
Authors: Miyamoto Naoki , Kondo Kazuya , Bando Yoshimi , Izaki Fuyumi , Takeuchi Taihei , Sumitomo Hiroyuki , Sakamoto Shinichi , Takashima Mika , Kawakita Naoya , Toba Hiroaki , Takizawa Hiromitsu 
Published: May 2023

Abstract
Background
Micronodular thymic carcinoma with lymphoid hyperplasia is an extremely rare thymic tumor, exhibiting a variety of cell morphologies with mild to severe dysmorphism. Since few cases have been reported, the prognosis of this disease is unclear.

Case presentation
A 55-year-old woman was referred to our hospital with an anterior mediastinal tumor. She was incidentally detected with a tumor in a medical examination. We diagnosed the patient with thymic carcinoma or thymoma and performed surgery via median sternotomy. Histologically, tumor cells showed weakly acidic vesicles and bright nuclei, including small nucleoli. Most of the tumor cells were cluster of differentiation (CD)5-positive, CD3-negative, and terminal deoxynucleotidyl transferase (TdT)-negative.

Conclusions
Based on these histological findings, the resected specimen was diagnosed as micronodular thymic carcinoma with lymphoid hyperplasia. The patient’s postoperative course was uneventful, and no signs of recurrence were observed at 5 years after the surgery.
Physical and Mental Health Disparities at the Intersection of Sexual and Gender Minority Statuses: Evidence From Population-Level Data
Authors: Stacey Lawrence , Wislar Wes 
Published: May 2023

Abstract
Sexual and gender minorities (SGM) experience detriments across many physical and mental health outcomes compared with heterosexual and cisgender people. But little is known about health outcomes for those who are both gender minorities and sexual minorities. Motivated by theories of double disadvantage and leveraging advancements in data collection and measurement, we examine physical and mental health disparities across sexual and gender minority statuses: cisgender heterosexuals, gender minority heterosexuals, cisgender sexual minorities, and people who are both gender and sexual minorities. Using Gallup's National Health and Well-Being Index (N = 93,144) and the Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System (N = 543,717), we estimate multivariable logistic regression models to examine how sexual and gender minority statuses are associated with poor/fair self-rated health, functional limitations, and diagnosed depression. Regression models adjusting for sociodemographic characteristics show marked physical and mental health disparities: people who are both gender and sexual minorities report greater odds of poor/fair self-rated health, functional limitations, and depression relative to cisgender heterosexuals and, in some cases, relative to gender minority heterosexuals and cisgender sexual minorities. Our results add to a growing body of research documenting the association between multiple disadvantaged statuses and health and provide novel information on SGM health disparities.
Protocol for Safety and Efficacy of MLC901 (NeuroAiD II) in Patients With Moderate Traumatic Brain Injury: A Randomized Double-Blind Placebo-Controlled Trial (ANDROMEDA)
Authors: Chua Annabell E. , Yacapin Vilma Jane , Manalo Guillermo L. , Ledesma Lourdes K. 
Published: May 2023

BACKGROUND AND OBJECTIVES:
Traumatic brain injury (TBI) remains a leading cause of death and disability, affecting approximately 69 million individuals each year worldwide. A significant portion of TBI research has focused on treatments for neuroprotection and/or neurorecovery, with most failing to transition to successful clinical applications despite promising animal/in vitro study results. MLC901 (NeuroAiD II), with origins from a traditional Chinese medicine, has been shown to exhibit both neuroprotective and neuroregenerative properties in in vitro and animal studies for stroke and TBI. Clinical trials have demonstrated its safety with significant improvements in some functional outcome and cognitive domain measures. The objective of this study is to determine the efficacy and safety of MLC901 (NeuroAiD II) vs placebo in adult patients with moderate TBI.

METHODS:
This is a multicenter randomized double-blind placebo-controlled trial that aims to enroll 120 adult patients with moderate TBI receiving standard of care in 2 arms: MLC901 vs placebo for a treatment period of 6 months with a further follow-up of 3 months. The total duration of the study is 9 months. The primary end point is Glasgow Outcome Scale Extended (GOS-E) at 6 months. Other assessments include mortality at 6 months, GOS-E, Glasgow Coma Scale, Montreal Cognitive Assessment Filipino Version, Frontal Assessment Battery Conflicting Instructions and Go-No-Go, Rivermead Post-Concussion Symptom Questionnaire, Barthel Index, Hospital Anxiety and Depression Scale, and Health related Quality of life (EQ-5D) at 1, 3, 6, and 9 months. Cerebral swelling at baseline and at 1 and 2 weeks will also be documented. Adverse events and drug compliance will also be monitored.

EXPECTED OUTCOMES:
We expect to find a significant improvement in functional and cognitive outcomes in patients who were given MLC901.

DISCUSSION:
Previous studies on the effect of MLC901 in adult patients with moderate TBI showed positive results; However, these studies are limited by the small number of patients. This study will establish a more definitive role of MLC901 in improving functional and cognitive outcomes in patients with moderate TBI.