bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal study of antibody response following SARS-CoV-2 vaccination with Pfizer-BioNTech BNT162b2
Authors: Robles Navas Leandra J. , Ortega Huete Juan J. , Juliá Sanchis María L. , Bravo Miró Jorge S. , Cervera Sánchez Serezade , Molina Gasset Ricardo 
Published: August 2023

Abstract

Objectives
To assess the immunity of healthcare and non-healthcare workers in the Alcoy health area (Spain) after completing three doses of the Pfizer-BioNTech vaccine and how it relates with individual factors.

Methods
We conducted a prospective, observational, longitudinal, analytical study to observe immunogenicity in healthcare and non-healthcare workers at Virgen de los Lirios Hospital following administration of three doses of the Pfizer-BioNTech vaccine. Anti-SARS-CoV-2 spike protein IgG antibody concentrations were determined, while COVID-19 infections were identified by qualitative detection of IgG against the nucleocapsid protein. Samples from volunteers were analyzed 15 days, 3 months, and 6 months after receiving the second vaccine dose, and 12 months after receiving the third (booster) dose. A questionnaire was used to collect demographic data, risk factors, and use of immunosuppressive drugs. Statistical analyses were performed with SPSS software, and mean antibody levels over time were compared using ANOVA.

Results
Participation was 99.5 % (199/200). The IgG concentration was higher in men and in obese individuals. No significant changes were noted in factors such as smoking.

Conclusions
All participants developed humoral immunity, except for three subjects who were receiving immunosuppressive treatment. Participants with previous COVID-19 infection had higher antibody levels.
Integral inequalities with an extended Poisson kernel and the existence of the extremals
Authors: Tao Chunxia , Wang Yike 
Published: August 2023

Abstract
In this article, we first apply the method of combining the interpolation theorem and weak-type estimate developed in Chen et al. to derive the Hardy-Littlewood-Sobolev inequality with an extended Poisson kernel. By using this inequality and weighted Hardy inequality, we further obtain the Stein-Weiss inequality with an extended Poisson kernel. For the extremal problem of the corresponding Stein-Weiss inequality, the presence of double-weighted exponents not being necessarily nonnegative makes it impossible to obtain the desired existence result through the usual technique of symmetrization and rearrangement. We then adopt the concentration compactness principle of double-weighted integral operator, which was first used by the authors in Chen et al. to overcome this difficulty and obtain the existence of the extremals. Finally, the regularity of the positive solution for integral system related with the extended kernel is also considered in this article. Our regularity result also avoids the nonnegativity condition of double-weighted exponents, which is a common assumption in dealing with the regularity of positive solutions of the double-weighted integral systems in the literatures.
Treatment activity of the injectable hydrogels loaded with dexamethasone In(iii) complex on glioma by inhibiting the VEGF signaling pathway
Authors: Yu Hongmei , Liang Weiwei , Sun Yuan 
Published: August 2023

Abstract
In this work, a novel In(iii) coordination polymer, i.e., {[In(L)(im)(H2O)](H2O)}
n
(1) was produced from the synthetic reactions in water and dimethylformamide mixed solvents and using methyl-3-hydroxy-5-carboxy-2-thiophenecarboxylic acid (H2L) and imidazole (Him) as the co-ligands, and then successfully loaded with dexamethasone. The injectable hydrogels were prepared from natural polysaccharide hyaluronic acid with good biocompatibility and successfully loaded with In(iii) complex. The suppressive inhibitory effect of hydrogels toward U251 human glioma cell line viability was assessed using the Cell Counting Kit-8 assay kit, and the relatively expressed levels of the vascular endothelial growth factor signaling pathway were determined by real-time RT-PCR.
Polymer-based nanocarriers for biomedical and environmental applications
Authors: Idris Dahir Sagir , Roy Arpita , Pandit Soumya , Alghamdi Saad , Almehmadi Mazen , Alsaiari Ahad Amer , Abdulaziz Osama , Alsharif Abdulaziz , Khandaker Mayeen Uddin , Faruque Mohammad Rashed Iqbal 
Published: August 2023

Abstract
Polymer-based nanocarriers are created from natural or synthetic polymers that are modified to form submicroscopic particles. The polymer matrix can be customized to provide specific properties, such as surface chemistry and flexibility. This allows the particles to be designed and used in different fields. They are promising nanomaterials that are used as therapeutic and diagnostic agents, and they have potential biomedical and environmental applications. These nanocarriers are polymers that can be engineered with other types of nanomaterials with different sizes, shapes, and compositions. They can deliver drugs or their cargo to a specific site with precisely controlled release. They have many advantages compared to traditional drug delivery carriers, including improved biocompatibility, reduced toxicity, and increased efficacy. In biomedical applications, polymer nanocarriers have been used as drug delivery carriers, cancer therapy, and gene therapy. In environmental applications, polymer nanocarriers are able to remove heavy metals and other contaminants from air and water bodies. In this review, a summary of recent fabrication, design, synthesis, characterisation, and various applications in the biomedical and environmental fields has been provided. The review also highlights the current challenges and prospects of evolving polymer nanocarriers.
Geochemical characteristics of arc fractionated I-type granitoids of eastern Tak Batholith, Thailand
Authors: Singtuen Vimoltip , Phajuy Burapha , Wichaiya Kittisak 
Published: August 2023

Abstract
The Tak Batholith is located in the western part of Thailand’s eastern granitoid belt. To better understand the geochemical characteristics of granitoid and identify their occurrence, rock samples collected from the eastern part of the Tak Batholith were used for petrographical, mineralogical, and geochemical analyses. According to field investigation and lithology, petrography classifies these granitic rocks as medium-grained granodiorite and granodioritic dike. The granodiorites are composed chiefly of plagioclase, orthoclase, quartz, hornblende, and biotite, with tiny amounts of zircon, apatite, and opaque minerals. Meanwhile, the granitic dike shows a highly porphyritic texture, presenting mostly plagioclase phenocrysts, with a small amount of orthoclase and unidentified mafic phenocrysts sitting in a fine-grained groundmass comprising K-feldspar and quartz with a small amount of plagioclase and present granophyric intergrowth. Geochemical data of the amphiboles classified them as Ferro-edenite symbolizing the I-type granite. Whole-rock geochemistry indicates that these rock suites are I-type metaluminous granodiorite, and diorite fractionated from the high K calc-alkaline magma melted from the mafic crust of arc magmatism agreeable with the enrichment of large ion lithophile elements and depletion of highfield-strength elements, and rare earth element patterns.
Harmonization of Product Classifications: A Consistent Time Series of Economic Trade Activities
Authors: Baumgartner Christoph , Srhoj Stjepan , Walde Janette 
Published: August 2023

Abstract
Firm-product data provide information for various research questions in international trade, industrial or innovation economics. However, working with these data requires harmonizing product classifications consistently over time to avoid internal validity issues. Harmonization is required because classification systems like the EU classifications combined nomenclature (CN) for goods or the Prodcom for the production of manufactured goods undergo several changes. We have addressed this problem and developed an approach to harmonize product codes. This approach tracks product codes from 1995 to 2022 for CN and 2001 to 2021 for Prodcom. Additional years can be conveniently added. We provide the harmonized product codes for CN and Prodcom in the selected period’s last (or first) year. Our approach is summarized in an open-source R package so that researchers can consistently track product codes for their selected period. We demonstrate the importance of harmonization using the micro-level trade data for Croatia as a case study. Our approach facilitates working with firm-product data, allowing the analysis of important research questions.
Further collection of Patrizi’s Trident Leaf-nosed Bat, Asellia patrizii De Beaux 1931, from Saudi Arabia with Echolocation data
Authors: Al Obaid Ahmed , Al Ghamdi Abdul Rahman , Al Malki Khaled , Shuraim Faisal , Al Boug Ahmad , Al Jbour Sharif , Amr Zuhair S. 
Published: August 2023

Abstract
Additional record for Asellia patrizii from As Saqid Island, Saudi Arabia, is reported. Illustrations for alive specimens are given for the first time. Current distribution for this species across its known range of distribution was provided. Echolocation data for A. patrizii is given for the first time, where it ranged from 133-139 KHz for maximum energy (average 135.22 ± 2.41). Calls were compared with two populations of Asellia tridens in Saudi Arabia and other regions in the Middle East.
The safety and immunogenicity to inactivated COVID-19 vaccine in patients with hyperlipemia
Authors: Yang Lei , Liu YaMing , Guo Qiao , Jiang DePeng 
Published: August 2023

Abstract
It is of urgent need to understand the safety and effectiveness of novel coronavirus (COVID-19)-inactivated vaccine in patients with hyperlipidemia (HLD). However, data on the safety and immune response of SARS-CoV-2-inactivated vaccine in HLD patients are limited. In this prospective study, 105 patients with HLD and 74 healthy controls (HCs) were selected. Within 16–168 days after inoculation-inactivated vaccine, the anti-receptor-binding domain (RBD) IgG and SARS-CoV-2 neutralizing antibodies (NAbs) were evaluated, respectively. Flow cytometry was performed to evaluate RBD-specific B cells and memory B cells. There was no significant difference between HLD patients and HCs in adverse events (AEs) within 7 days after vaccination, and no serious AEs occurred. The seropositivity rates and titers of two Abs (anti-RBD IgG and CoV-2 NAbs) were lower in HLD patients than in HCs (all, p < 0.05). HLD showed significantly lower frequencies of RBD-specific B cells than HCs (p = 0.040). However, in high cholesterol, high triglyceride, mixed (MiX), and lipid control (HC) subgroups, there was no significant difference in the seropositivity rates and titers of the both Abs. Through mixed factor analysis shows that days between the second dose and sample collection/antibody measurement were associated with the lower anti-RBD IgG antibody levels. In conclusion, inactivated COVID-19 vaccine is safe and well tolerated for HLD patients, but the humoral immune may be limited.
The application of iliac fascia space block combined with esketamine intravenous general anesthesia in PFNA surgery of the elderly: A prospective, single-center, controlled trial
Authors: Jia Xuandong , Liao Xingzhi , Zhou Maitao 
Published: August 2023

Abstract
To observe the effect of iliac fascia space block combined with esketamine intravenous general anesthesia in proximal femoral nail antirotation (PFNA) of the elderly. Eighty elderly patients who underwent PFNA were randomly divided into experimental group and control group. In the experimental group, iliac fascial block combined with esketamine and propofol intravenous general anesthesia was used to keep spontaneous breathing. The control group used iliac fascia block combined with remifentanil and propofol intravenous general anesthesia to maintain spontaneous breathing. Record important indexes such as heart rate (HR), mean arterial pressure (MAP), pulse oxygen saturation (SpO2), visual analogue score (VAS) scores, etc. at different moment during the operation. Trial data showed that there were significant differences in HR, MAP, and SpO2 between the two groups at the beginning of operation, and there was no significant difference in VAS scores between the two groups at each moment after surgery, and there were significant differences in the number of vasopressor applications, length of hospital stay, and QoR-15 scores between the two groups, and there were significant differences in the incidence of total adverse reactions and the incidence of hypotension. The trial indicated that patients in the experimental group have more stable hemodynamics and lower stress response, which is conducive to rapid recovery after surgery.
Vico’s Theory of Humor and Laughter
Authors: Peone Dustin 
Published: August 2023

Abstract
Giambattista Vico is a philosopher with a deeply tragic sense of life. His theory of the course of nations does not entail a notion of progress. Nations are born, mature, decline, and perish, and the nations that rise in their wake must begin again from barbarism. Nevertheless, Vico has a doctrine of humor and laughter, which he details in a digression within short apologia, the “Vici Vindiciae.” No significant scholarly attention has ever been paid to this digression. In this article, I critically consider Vico’s theory, with the greater intention of situating it in the context of his philosophy as a whole. I demonstrate that Vico’s association of “acute remarks” with the pursuit of truth, and his criticism of “argute remarks,” mockery, and laughter are an extension of his doctrine of the heroic mind. I also discuss the significance of Roman comedy for Vico as philologist.
Oppression, Subversive Humor, and Unstable Politics
Authors: Marvin Amy 
Published: August 2023

Abstract
This essay argues that humor can be used as an unstable weapon against oppressive language and concepts. Drawing from radical feminist Marilyn Frye, I discuss the difficulty of challenging systematic oppression from within and explore the capabilities of humor for this task. This requires expanding Cynthia Willett’s and Julie Willett’s approach to fumerism beyond affect to fully examine the work of humor in manipulating language, concepts, and imagery. For this expansion, I bring in research on feminist linguistics alongside other philosophers of political humor to consider the connection between humor and world-making. I then link this with feminist world-breaking through Monique Wittig’s analysis of war machines and Trojan horses against heteropatriarchal language. Finally, I draw out the instability of humor as a war machine by investigating a bit where comedian Patti Harrison disguised herself as an official corporate brand platform to challenge the compulsory commodification of LGBTQ rights.
A Kernel of Truth: Outlining an Epistemology of Jokes
Authors: Wilk Thomas 
Published: August 2023

Abstract
I propose the Shared Presupposition Norm of Joking (SPNJ) as a constitutive norm of joke-telling. This norm suggests that a person should only tell a joke if they believe their audience shares the presuppositions—both explicit beliefs and implicit inferential connections—upon which the joke turns. Without this shared understanding, the audience would lack the necessary comprehension to appreciate the joke. I defend this norm in an analogous way to Williamson’s defense of the Knowledge Norm of Assertion by demonstrating that it explains a number of patterns of joking behavior. If SPNJ is indeed a constitutive norm of joking, it provides an epistemological foothold. Jokes function as conversational explicatures serving an epistemically diagnostic function, revealing implicit and perhaps disavowed inferential dispositions of the joking community. This norm does not teach us about the subject matter of the joke, but instead illuminates the language games of the joke teller and audience.
Ion Beam–Induced Modifications in the Optical and Structural Characteristics of Lexan Polycarbonate
Authors: Ramola R. C. , Semwal Anju 
Published: August 2023

Abstract
Lexan polycarbonate samples have been irradiated with lithium, Li+3 (50 MeV) and nickel, Ni+9 (120 MeV) ion beams at the fluence ranging from 3 × 1010 to 3 × 1012 ions/cm2. The effects of ion beam irradiation on Lexan polycarbonate were investigated using x-ray diffraction (XRD), ultraviolet (UV)-visible, and atomic force microscopy (AFM). The UV-visible spectra of ion beam–irradiated films reveal that the optical band gap of polycarbonate decreases with increasing ion beam fluence. The optical band gap shrinks more after irradiation by nickel ion beam because it loses more electronic energy than lithium-ion beams. The number of carbon atoms in carbon clusters incorporated in the Lexan polycarbonate is studied in relation to the optical band gap. The XRD analysis reveals that the intensity of the main peak decreases with increasing ion fluence, indicating the amorphization of Lexan polycarbonate. AFM analysis indicates systematic changes in the surface morphology of polymer films as beam intensity increases.
Hematopoiesis: a BETter understanding
Authors: Dasgupta Nirmalya , Adams Peter D 
Published: August 2023

Epigenetic modifications are known to be crucial for hematopoietic stem cell (HSC) differentiation, with the BET family member BRD4 playing a vital role in this as an epigenetic reader. In this issue of EMBO reports, Yang et al (2023) demonstrate that the absence of BRD4 leads to senescence in HSCs and hematopoietic progenitor cells (HPCs), affecting the expression of crucial genes involved in myeloid and erythroid development. These data suggest that BRD4 has a protective role in preserving histone tails, thereby sustaining normal HSC/HPC functions.
Fenomenologia miłości Sørena Kierkegaarda: miłość zmysłowa – miłość wieczna – lęk
Authors: Tkacz Malwina 
Published: August 2023

Cel. Celem artykułu jest przedstawienie fenomenu miłości w filozofii Sørena Kierkegaarda. Filozof ten wyróżnia wiele kategorii miłości – od miłości preferencyjnej po agape.
Metody. Metodę badań stanowi analiza wybranych publikacji naukowych i popularnonaukowych oraz tekstów filozoficznych.
Wyniki. Fenomen miłości w ujęciu Kierkegaarda przybiera wiele form i ujawnia się w różnych kate­goriach. Nie istnieje wiele fenomenów – istnieją różne ich przejawy, a koncepcja miłości zunifikowanej jest możliwa.
Wnioski. Miłość preferencyjna i miłość bliźniego nie wykluczają się – są w pe­wien sposób zależne, a przynajmniej mają „punkty wspólne”. Zależność ta wydaje się być obiecującym gruntem dla dalszej analizy i badań.
Ludovico Antonio Muratori y la problemática del buen gusto en la cultura italiana a principios del siglo XVIII
Authors: Núñez-García Laureano 
Published: August 2023

El término gusto empezó a adquirir relevancia en el debate estético-literario en Italia en la última década del siglo XVII y principios de siglo XVIII, época en la que la cultura y la literatura italianas eran conscientes de encontrarse en una fase de decadencia debida al agotamiento del barroco.
El presente estudio pretende analizar el sentido que el concepto o idea de buen gusto adquiere en el tratado Riflessioni sopra il buon gusto nelle scienze e nelle arti (1708 y 1715) de Ludovico Antonio Muratori, sin duda el autor más representativo del pensamiento estético y de la crítica literaria de su tiempo. El tratado está concebido como un ambicioso proyecto de reforma y renovación de la vida cultural y literaria italiana, en el que la idea de buen gusto debía jugar un papel fundamental. Pero como el estudio pretende demostrar, a pesar del mérito de la obra de Muratori y su influencia en autores posteriores, su idea de buen gusto permaneció fundamentalmente asociada a la de juicio, es decir, a una facultad intelectual, racional, capaz de distinguir entre lo que es y no es bello, y no como algo propio de la sensibilidad desde el punto de vista de la fruición.
Pengembangan E-Modul Kompetensi Dasar Menggambar Komik Berkarakter Wayang untuk Siswa SMP
Authors: Dipura Indah Dwi Cahyanti , Iriaji  , Anggriani Swastika Dhesti 
Published: August 2023

Era globalisasi menggerus pengetahuan remaja mengenai budaya lokal khususnya pewayangan sehingga rasa cinta remaja terhadap budayanya sendiri semakin memudar seperti remaja yang menyukai K-Pop, Anime, J-Pop dsb. Pengembangan bahan ajar yang mengangkat kebudayaan khususnya pewayangan terbatas sehingga peneliti mengembangkan e-modul dengan menyisipkan karakter pewayangan. Tujuan penelitian yaitu mengembangkan dan menghasilkan e-modul kompetensi dasar menggambar komik berkarakter wayang. Metode penelitian ini menggunakan penelitian dan pengembangan dengan model pengembangan ADDIE terdiri dari: (1) analisis; (2) desain; (3) pengembangan; (4) implementasi; dan (5) evaluasi. Pengambilan data menggunakan teknik kualitatif dan kuantitatif. Penelitian ini menghasilkan e-modul menggambar komik berkarak­ter wayang untuk kelas VIII yang telah divalidasi. Instrumen yang digunakan yaitu angket uji validasi ahli, angket uji efektivitas oleh peserta didik dan pretest posttest. Hasil penelitian dan pengembangan yaitu e-modul yang telah dikembangkan sangat efektif dalam meningkatkan pemahaman dan ketertarikan peserta didik dalam mempelajari materi lebih cepat karena terdapat ilustrasi wayang yang membantu mengarahkan peserta didik ketika mempelajari e-modul.
Kata kunci: e-modul, kompetensi dasar, menggambar komik, berkarakter wayang
Developing E-Module on Basic Competencies of Drawing Comics with Wayang Characters for Senior High School Students’
The era of globalization has eroded adolescents' knowledge of local culture, especially puppetry, so that adolescents' love for their own culture is fading, such as teenagers who like K-Pop, Anime, J-Pop, and so on. The development of teaching materials that raise culture, especially puppetry, is limited so that researchers develop e-modules by inserting puppet characters. The purpose of the research is to develop and produce e-modules for basic competencies in drawing comics with puppet characters. This research method uses research and development with the ADDIE development model consisting of: (1) analysis; (2) design; (3) development; (4) implementation; and (5) evalua­tion. Data were collected using qualitative and quantitative techniques. This research produced a validated e-module for drawing comics with puppet characters for class VIII. The instruments used are expert validation test questionnaire, effectiveness test questionnaire by students and pretest posttest. The results of research and development are e-modules that have been developed are very effective in increasing students' understanding and interest in learning the material faster because there are puppet illustrations that help direct students when studying e-modules.
Keywords: e-module, basic competency, drawing comics, wayang characters