bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating cardiac function with chest computed tomography in acute ischemic stroke: feasibility and correlation with short-term outcome
Authors: Bao Jie , Wang Chen , Zhang Yimeng , Su Zhuangzhi , Du Xiangying , Lu Jie 
Published: July 2023

BackgroundThe outcomes of patients with acute ischemic stroke (AIS) are related to cardiac function. Cardiac insufficiency can manifest as hydrostatic changes in the lungs. Computed tomography (CT) of the chest is commonly used for screening pulmonary abnormalities and provides an opportunity to assess cardiac function.PurposeTo evaluate the correlation between hydrostatic lung manifestations on chest CT and cardiac function with its potential to predict the short-term outcome of AIS patients.MethodsWe retrospectively analyzed AIS patients who had undergone chest CT at admission and echocardiogram within 48 h. Morphological and quantitative hydrostatic changes and left ventricular dimensions were assessed using chest CT. Improvement in the National Institutes of Health Stroke Scale (NIHSS) score on the seventh day determined short-term outcomes. Multivariate analysis examined the correspondence between hydrostatic lung manifestations, left ventricular dimension, and left ventricle ejection fraction (LVEF) on echocardiography, and the correlation between hydrostatic changes and short-term outcomes.ResultsWe included 204 patients from January to December 2021. With the progression of hydrostatic changes on chest CT, the LVEF on echocardiography gradually decreased (p &lt; 0.05). Of the 204, 53 patients (26%) with varying degrees of hypostatic lung manifestations had less improvement in the NIHSS score (p &lt; 0.05). The density ratio of the anterior/posterior lung on CT showed a significant negative correlation with improvement in the NIHSS score (r = −5.518, p &lt; 0.05). Additionally, patients with a baseline NIHSS ≥4 with left ventricular enlargement had significantly lower LVEF than that of patients with normal NIHSS scores.ConclusionHydrostatic lung changes on chest CT can be used as an indicator of cardiac function and as a preliminary reference for short-term outcome in AIS patients.
A worldwide bibliometric analysis of acromegaly in the past two decades: 1999–2022
Authors: Peng Shuqin , Liu Qi , Teng Yuanyuan , Huang Biling , Liu Ze , Li Mingliu , Liang Jieyu , Zhang Yi , Wang Min 
Published: July 2023

ObjectivesTo conduct a bibliometric analysis to quantify and identify the current status and trends of acromegaly research in the past two decades.Materials and methodsArticles related to acromegaly that were published from 1999 to 2022 were retrieved through the Web of Science core collection (WoSCC) database. Then, they were imported into VOSviewer and CiteSpace to conduct a visualization analysis of authors, countries, institutions, citation numbers, cocitations, keywords, and references.ResultsA total of 3,909 articles were identified in the study. Among them, the United States made the largest contribution to the field. Moreover, Colao A. was the most prolific author, and the University of Naples Federico II was the institution with the most publications. In addition, the Journal of Clinical Endocrinology and Metabolism was the core journal in the field. High-frequency keywords mainly included “acromegaly,” “GH (Growth Hormone),” “IGH-I (Insulin-Like Growth Factor I),” “pituitary adenomas,” and “octreotide.”ConclusionStudies related to acromegaly have shown stable stepwise growth over the past two decades. Interestingly, the research focus after 2016 gradually shifted from the etiology, mechanism, medications for treatment, and complications to improving prognosis and quality of life of patients with acromegaly. The current findings may provide guidance for further research in the field of acromegaly.
Disruption in the regulation of casein kinase 2 in circadian rhythm leads to pathological states: cancer, diabetes and neurodegenerative disorders
Authors: Malik Md. Zubbair , Dashti Mohammed , Fatima Yasmin , Channanath Arshad , John Sumi Elsa , Singh R. K. Brojen , Al-Mulla Fahd , Thanaraj Thangavel Alphonse 
Published: July 2023

IntroductionCircadian rhythm maintains the sleep–wake cycle in biological systems. Various biological activities are regulated and modulated by the circadian rhythm, disruption of which can result in onset of diseases. Robust rhythms of phosphorylation profiles and abundances of PERIOD (PER) proteins are thought to be the master keys that drive circadian clock functions. The role of casein kinase 2 (CK2) in circadian rhythm via its direct interactions with the PER protein has been extensively studied; however, the exact mechanism by which it affects circadian rhythms at the molecular level is not known.MethodsHere, we propose an extended circadian rhythm model in Drosophila that incorporates the crosstalk between the PER protein and CK2. We studied the regulatory role of CK2 in the dynamics of PER proteins involved in circadian rhythm using the stochastic simulation algorithm.ResultsWe observed that variations in the concentration of CK2 in the circadian rhythm model modulates the PER protein dynamics at different cellular states, namely, active, weakly active, and rhythmic death. These oscillatory states may correspond to distinct pathological cellular states of the living system. We find molecular noise at the expression level of CK2 to switch normal circadian rhythm to any of the three above-mentioned circadian oscillatory states. Our results suggest that the concentration levels of CK2 in the system has a strong impact on its dynamics, which is reflected in the time evolution of PER protein.DiscussionWe believe that our findings can contribute towards understanding the molecular mechanisms of circadian dysregulation in pathways driven by the PER mutant genes and their pathological states, including cancer, obesity, diabetes, neurodegenerative disorders, and socio-psychological disease.
Non-invasive preoperative prediction of Edmondson-Steiner grade of hepatocellular carcinoma based on contrast-enhanced ultrasound using ensemble learning
Authors: Wang Yao , Yuan Dongbo , Sun Hang , Pan Xiaoguang , Lu Fangnan , Li Hong , Huang Ying , Tang Shaoshan 
Published: July 2023

PurposeThis study aimed to explore the clinical value of non-invasive preoperative Edmondson-Steiner grade of hepatocellular carcinoma (HCC) using contrast-enhanced ultrasound (CEUS).Methods212 cases of HCCs were retrospectively included, including 83 cases of high-grade HCCs and 129 cases of low-grade HCCs. Three representative CEUS images were selected from the arterial phase, portal vein phase, and delayed phase and stored in a 3-dimensional array. ITK-SNAP was used to segment the tumor lesions manually. The Radiomics method was conducted to extract high-dimensional features on these contrast-enhanced ultrasound images. Then the independent sample T-test and the Least Absolute Shrinkage and Selection Operator (LASSO) were employed to reduce the feature dimensions. The optimized features were modeled by a classifier based on ensemble learning, and the Edmondson Steiner grading was predicted in an independent testing set using this model.ResultsA total of 1338 features were extracted from the 3D images. After the dimension reduction, 10 features were finally selected to establish the model. In the independent testing set, the integrated model performed best, with an AUC of 0.931.ConclusionThis study proposed an Edmondson-Steiner grading method for HCC with CEUS. The method has good classification performance on independent testing sets, which can provide quantitative analysis support for clinical decision-making.
Value of loop electrosurgical excision procedure conization and imaging for the diagnosis of papillary squamous cell carcinoma of the cervix
Authors: Cui Can , Chen Ziren , Luo Lingxiao , Zeng Jianping , Sun Xiaoyi , Sui Long , Xu Congjian , Fu Zhongpeng , Cong Qing 
Published: July 2023

BackgroundLoop electrosurgical excision procedure (LEEP) conization and hysterectomy are performed for some patients with papillary squamous cell carcinoma (PSCC), whereas only hysterectomy is performed for others. We aimed to determine the optimal management for PSCC.MethodsPatients diagnosed with PSCC by colposcopy-directed biopsy between June 2008 and January 2020 who underwent LEEP conization and hysterectomy or only hysterectomy at our hospital were enrolled. Results of cervical cytology, high-risk human papillomavirus testing, transvaginal sonography, pelvic magnetic resonance imaging, LEEP, hysterectomy, and pathology testing of colposcopy-directed biopsy samples were analyzed.ResultsA total of 379 women were diagnosed with PSCC by colposcopy-directed biopsy; 174 underwent LEEP before hysterectomy and 205 underwent only hysterectomy. Patients underwent and did not undergo LEEP were aged 47 ± 11 years and 52 ± 11 years, respectively. Among women who underwent LEEP, the agreement between LEEP and hysterectomy pathology was 85.1%. For women who underwent only hysterectomy, the agreement between preoperative clinical staging and pathological staging after hysterectomy was 82.4%. For patients with preoperative imaging indicative of malignancy, the accuracy of LEEP for diagnosing and staging PSCC was 88.5%, whereas for the hysterectomy-only group, it was 86.2%. For patients without malignancy detected with imaging, the accuracy of LEEP for diagnosing and staging PSCC was 81.6%; however, for those who did not undergo LEEP, it was 70.0%.ConclusionFor women diagnosed with PSCC by colposcopy-directed biopsy, LEEP conization is necessary for an accurate diagnosis when imaging does not indicate cancer; however, LEEP is not necessary when imaging indicates cancer.
Financial burden of men with localized prostate cancer: a process paper
Authors: Housten Ashley J. , Rice Hannah E. , Chang Su-Hsin , L'Hotta Allison J. , Kim Eric H. , Drake Bettina F. , Wright-Jones Robin , Politi Mary C. 
Published: July 2023

BackgroundMany individuals undergoing cancer treatment experience substantial financial hardship, often referred to as financial toxicity (FT). Those undergoing prostate cancer treatment may experience FT and its impact can exacerbate disparate health outcomes. Localized prostate cancer treatment options include: radiation, surgery, and/or active surveillance. Quality of life tradeoffs and costs differ between treatment options. In this project, our aim was to quantify direct healthcare costs to support patients and clinicians as they discuss prostate cancer treatment options. We provide the transparent steps to estimate healthcare costs associated with treatment for localized prostate cancer among the privately insured population using a large claims dataset.MethodsTo quantify the costs associated with their prostate cancer treatment, we used data from the Truven Health Analytics MarketScan Commercial Claims and Encounters, including MarketScan Medicaid, and peer reviewed literature. Strategies to estimate costs included: (1) identifying the problem, (2) engaging a multidisciplinary team, (3) reviewing the literature and identifying the database, (4) identifying outcomes, (5) defining the cohort, and (6) designing the analytic plan. The costs consist of patient, clinician, and system/facility costs, at 1-year, 3-years, and 5-years following diagnosis.ResultsWe outline our specific strategies to estimate costs, including: defining complex research questions, defining the study population, defining initial prostate cancer treatment, linking facility and provider level related costs, and developing a shared understanding of definitions on our research team.Discussion and next stepsAnalyses are underway. We plan to include these costs in a prostate cancer patient decision aid alongside other clinical tradeoffs.
Willingness to pay for hepatitis B virus vaccine and associated factors among households in Bahir Dar City, northwest Ethiopia: using contingent valuation method
Authors: Aychew Addis , Minyihun Amare , Tsehay Chalie Tadie , Amare Tsegaw , Aschalew Andualem Yalew 
Published: July 2023

BackgroundThe prevention of disease burden and death through vaccination is one of the most cost-effective methods. Even though the Hepatitis B Virus (HBV) has significant public health problems in Ethiopia, there is no compulsory HBV vaccination program for adults and the vaccine's market value was not yet estimated in the Ethiopia context. Therefore, this study aimed to assess the willingness to pay (WTP) for the HBV vaccine and its associated factors among households in Bahir Dar City, northwest Ethiopia.MethodsA cross-sectional study was conducted among 620 households from March 1 to 30, 2020. A systematic random sampling technique was employed to select the required number of households. An interviewer-administered questionnaire was used to collect the necessary information. The contingent valuation method was conducted to measure WTP for the HBV vaccine. A Tobit regression model was employed to investigate significantly associated factors, and variables with a p-value of &lt;0.05 were considered statistically significant.ResultsIn this study, 62.17% of households were willing to pay for the HBV vaccine with an average cost of ETB174.24 (US$5.25). Male household heads (P = 0.014), favorable attitude (P = 0.017), and good knowledge (P &lt; 0.001) toward the vaccine were positively associated with WTP, whereas age (P &lt; 0.001), single marital status (P = 0.012) and divorced/widowed (P = 0.018) marital status were negatively associated with WTP.ConclusionsOverall, most households were willing to pay for the HBV vaccine with an average demand of ETB174.24 (US$5.25). Therefore, a national-level HBV vaccine strategy should be designed considering the households' willingness to pay. In addition, working on attitudes and knowledge toward the vaccine could potentially increase the household's willingness to pay for the HBV vaccine.
Salmonella gallinarum strains from outbreaks of fowl typhoid fever in Southern Africa closely related to SG9R vaccines
Authors: Beylefeld Amanda , Abolnik Celia 
Published: July 2023

IntroductionSalmonella enterica subspecies enterica serovar Gallinarum biovar Gallinarum (SG) is associated with fowl typhoid fever, and the attenuated rough strain SG9R is widely used as a vaccine in many regions. Reversion to virulence of vaccine strains was suspected as the cause during recent fowl typhoid fever outbreaks in poultry in South Africa and Eswatini.MethodsTo compare nine field isolates with global wild-type SG9 strains and the two commercial SG9R vaccines in use, Nobilis® SG9R and Cevac®-SG, we used whole-genome comparison with single-nucleotide polymorphism (SNP) detection.ResultsSNP phylogenic analysis showed that all the southern African field isolates were more closely related to the vaccine strains than wild-type SG9 strains. Furthermore, SNPs in the pyruvate dehydrogenase (aceE) and/or lipopolysaccharide 1,2-glucosyltransferase (rfaJ) genes, which are known markers of attenuation, were found in four of the field isolates along with intact spv, SPI-1, and SPI-2 gene clusters, providing conclusive evidence that these four isolates were originally vaccine strains that reverted to virulence. Five other field isolates lacked the SG9R attenuation markers, but variant analysis identified an SNP in the yihX gene, insertions in the ybjX and hydH genes, and deletions in the ftsK and sadA genes that were shared between the field isolates and vaccine strains but absent in wild-type SG9, indicating that these field isolates were also likely revertant vaccines.DiscussionOverall, this study highlights different mechanisms of reversion of two commercial vaccines, where virulence caused by field isolates closely related to the Nobilis® SG9R vaccine was associated with the restoration of intact virulence gene clusters, and those derived from the Cevac®-SG vaccine were characterized by point mutations resulting in restored aceE and rfaJ genes. A possible new marker of attenuation was identified as a point mutation in the yihX gene, as well as four new candidate genes that could potentially be used to distinguish current vaccine strains from wild-type strains using PCR assays.
Sur l'aptitude à la production de l’antitoxine tétanique créée chez le Cheval par la vaccination au moyen de l'anatoxine spécifique ; conséquences
Authors: Ramon Gaston , Richou Rémy 
Published: July 2023

Alors qu’il est facile d’avoir rapidement et économiquement des sérums de titre élevé en utilisant des chevaux antérieurement vaccinés contre le tétanos, ces sujets ayant une aptitude remarquable à la production de l’antitoxine spécifique, il est impossible de produire de tels sérums chez des sujets non antérieurement vaccinés, ce n’est qu’après une longue période d’immunisation qu’on peut obtenir, chez quelques-uns d’entre eux, des sérums utilisables.
Cette importante disproportion dans les résultats obtenus donne la mesure de l’énorme différence d’aptitude de production de l’antitoxine spécifique entre les chevaux non antérieurement vaccinés et les chevaux antérieurement vaccinés.
Il s’agit là non d’un des moindres intérêts de la vaccination antitétanique dont la généralisation dans l’armée française a permis d’obtenir des chevaux si admirablement préparés à la production de l’antitoxine spécifique.
Malheureusement, les chevaux de réforme de l’armée ont pratiquement disparu ; nombreux sont encore ceux de la population civile qui n’ont pas bénéficié de cette vaccination, et si on peut espérer y puiser de temps à autre quelques chevaux vaccinés, nous connaîtrons encore, durant un certain temps, la pénurie des chevaux antérieurement vaccinés, d’ici que la vaccination puisse être appliquée aux nouveaux effectifs militaires en formation. Ce ne sera au plus tôt que l’an prochain que de tels chevaux pourront être mis à la production du sérum antitétanique.
Cette rareté actuelle des chevaux de réforme de l’armée, les seuls sur lesquels on peut avoir aujourd’hui dans la pratique des renseignements quant à la vaccination antérieure, l’impossibilité de différencier par le titrage avant l’immunisation l’immunité passive et l’immunité active, la complication fréquente du dosage des traces d’antitoxine que recèle parfois le sérum des sujets très anciennement vaccinés, l’impossibilité de savoir si la vaccination d’un cheval donné n’est pas de date très récente, expliquent les grandes difficultés auxquelles on se heurte actuellement dans la production intensive de l’antitoxine tétanique.
APAKAH ELEMEN CORPORATE GOVERNANCE DAPAT MENGURANGI FINANCIAL DISTRESS PADA PERUSAHAAN BERISIKO TINGGI?
Authors: Agustin Isnaini Nuzula , Andryanto  
Published: July 2023

This study examine the role of Corporate governance (proxied by audit committee independence variables, institutional ownership, independent commissioners, board size) and enterprise risk management in predicting the emergence of corporate financial distress. The research design is quantitative. The research object or population studied is mining companies listed on the Indonesia Stock Exchange (IDX) during the period of 2016-2021. The method used for determining the research sample is purposive sampling, namely determining the sample from the existing population based on predetermined criteria obtaining research sample of 132 observations. All data sets are sourced from the Indonesia Stock Exchange website. This study is employing Panel Regression Analysis including descriptive statistics analysis, correlation, and hypothesis testing using the EViews 12 software. The result posits that institutional ownership has a significant positive effect on financial distress, while the independence of the audit committee, independent commissioners, board size, enterprise risk management do not have a significant impact on financial distress. Further, the control variable of this study, namely company size, has a significant negative effect on financial distress. This study is expected to have significant contribution to Mining enterprise’s stakeholder in examining prominent factors in predicting financial distress.
PENYULUHAN GIZI SEIMBANG DAN OLAHAN PANGAN LOKAL UNTUK MENCEGAH STUNTING
Authors: G S a l i n , Marihi La Ode , O S u m a r t o n , Tuharea Farida 
Published: July 2023

Sumber Daya Manusia (SDM) merupakan kunci bagi pembangunan sebuah bangsa. Dari aspek kesehatan, salah satunya kekurangan gizi pada awal kehidupan berpengaruh pada kualitas SDM di masa depan. Salah satu ancaman terbesar pembangunan kesehatan yang dihadapi Indonesia adalah stunting. Stunting adalah kondisi dimana tinggi badan anak lebih pendek dari anak dengan usia yang sama. Sehingga diperlukan edukasi sedini mungkin untuk mencegah stunting pada anak dan balita melalui sosialisasi mengenai gizi seimbang dan olahan pangan lokal di Kelurahan Margasari, Buah Batu Bandung. Metode yang dilakukan melalui beberapa tahapan yakni tahap persiapan dan tahap pelaksanaan. Edukasi diberikan kepada perwakilan kader posyandu, kader desa, serta masyarakat umum. Materi di berikan secara terstruktur yakni materi mengenai gizi seimbang beserta pentingnya edukasi mengenai pencegahan stunting, faktor penyebabnya, serta deteksi dini gejala stunting. Kegiatan penyuluhan mengenai Gizi Seimbang dan Olahan Pangan Lokal Untuk Mencegah Stunting ini di hadiri oleh perwakilan kader posyandu, kader desa, serta masyarakat umum dengan jumlah peserta kurang lebih 85 orang. Diharapkan melalui kegiatan ini dapat meningkatkan pengetahuan pencegahan stunting dan keterampilan dalam memodifikasi makanan serta memantau tumbuh kembang balita dan anak.
Intonazio Ereduak Zeanurin
Authors: Gaminde Iñaki 
Published: July 2023

Artikulu honetan Zeanuriko euskararen intonazio eredu nagusien azterketa aurkezten dugu. Azterketa fonetikoarekin batera, datuen azalpenerako, azterketa fonologikoa ere dakargu.
Zeanuriko intonazio ereduek interes handia daukate, izan ere, hobeto ezagutzen ditugun Bizkaiko itsasaldeko ereduen aldean, Zeanuriko eredua, Bizkaiko hegoaldean kokaturik, nahikoa desberdina da. Datuak jasotzeko erabili dugun metodologia eta bertako azentu ereduaren ezaugarri nagusiak azaldu eta ostean, esaldi deklaratzaile eta galderazkoen azterketa egiten dugu.
Pengaruh Latihan Lateral Crossover Terhadap Peningkatan Kecepatan Tendangan Taekwondo
Authors: Wardhani Rio , Yane Stephani 
Published: July 2023

Penelitian ini bertujuan untuk mengetahui pengaruh latihan lateral crossover terhadap kecepatan tendangan taekwondo dollyo chagi di klub NTC Kota Pontianak. Penelitian ini adalah penelitian kuantitatif. Yang merupakan suatu cara untuk mengukur pengaruh latihan lateral crossover terhadap kecepatan tendangan taekwondo dollyo chagi di klub NTC Kota Pontianak, dengan jumlah sampel 8 orang atlit putra kategori kelas junior. Sampel yang digunakan yang memiliki karakteristik jenis kelamin laki-laki berusia 15-17 tahun yang masih aktif latihan di klub NTC Kota Pontianak dengan teknik total sampling. Teknik pengumpulan data berupa pengukuran dan menggunakan alat berupa tes kecepatan tendangan taekwondo dollyo chagi. Penelitian dilaksanakan selama dua sampai tiga bulan.