bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate Power and Accountability in International Economic Law
Authors: Low Lucinda A 
Published: January 2023

ABSTRACT
Over the past twenty-five years, States, international institutions, and private entities have attempted to rein in corruption and promote corporate social responsibility. Such efforts have produced mixed results but have led to greater international cooperation and the establishment of clear norms. Increasing the accountability of multinational corporate actors remains a challenge but depends upon cooperation among boards of directors, national governments, nongovernmental organizations, and international institutions. This paper analyzes the relationship among municipal statutes, nonbinding ‘soft law’, and private standards. None on their own can effectively solve the problem of irresponsible corporate behavior but together have made meaningful steps in creating a more fair and accountable business environment.
Taking Stakeholder Engagement in International Policy-Making Seriously: Is the WTO Finally Opening Up?
Authors: Pauwelyn Joost 
Published: January 2023

ABSTRACT
In the face of multiple global challenges, major policy-making initiatives are under way at various international fora. In many of these talks and discussions, a central question is how to fairly and effectively engage external stakeholders. While lagging behind for decades, the World Trade Organization has woken up to the potential of more actively engaging stakeholders in international trade policy-making, both to make better policies and mitigate implementation challenges. This contribution describes the groundbreaking steps taken in a number of Member-led informal discussions and dialogues: the Trade and Environmental Sustainability Structured Discussions and the Informal Dialogue on Plastics Pollution and Environmentally Sustainable Plastics Trade. The objective of this contribution is to describe and applaud recent developments and initiate a discussion on how the process can be made more inclusive and robust and, potentially, also be extended to formal World Trade Organization activities. In this context, the World Health Organization’s ongoing negotiations on a new pandemic treaty are used to offer an interesting point of comparison.
A new Pipistrelle bat from the oceanic Island of Príncipe (Western Central Africa)
Authors: Juste Javier , Torrent Laura , Méndez-Rodríguez Aline , Howard Kelli , García-Mudarra Juan Luis , Nogueras Jesús , Ibáñez Carlos 
Published: January 2023

AbstractWe describe a population of pipistrelle-like bats from Príncipe Island (Gulf of Guinea, Western Central Africa) as a new species based on the molecular and morphological characteristics of six specimens collected more than 30 years ago. The description of this new species was not possible until the traditionally entangled systematics of the whole pipistrelle group was clarified in recent years with the inclusion of molecular techniques and adequate species sampling. In this new taxonomic framework, the new species was clearly included within the dark-winged group of the recently described genus Pseudoromicia. The pipistrelles from Príncipe Island present a moderately inflated skull in lateral view with inner upper incisors that are moderately bicuspids and a baculum distinctly long with expanded tips. Besides these morphological characters, the new bat species is distinguished by its dwarfism, being the smallest species recognized within the genus. The ecology and conservation status of this endemic island species are unknown and field studies are urgently needed to evaluate the situation and conservation threats to this new species in its natural habitat.
Glyphosate exposure and urinary oxidative stress biomarkers in the Agricultural Health Study
Authors: Chang Vicky C , Andreotti Gabriella , Ospina Maria , Parks Christine G , Liu Danping , Shearer Joseph J , Rothman Nathaniel , Silverman Debra T , Sandler Dale P , Calafat Antonia M , Beane Freeman Laura E , Hofmann Jonathan N 
Published: January 2023

AbstractBackgroundGlyphosate is the most widely applied herbicide worldwide, and its use has been associated with increased risks of certain hematopoietic cancers in epidemiologic studies. Animal and in vitro experiments suggest that glyphosate may induce oxidative stress, a key characteristic of carcinogens; however, evidence in human populations remains scarce. We investigated associations between glyphosate exposure and urinary oxidative stress biomarkers in the Biomarkers of Exposure and Effect in Agriculture study, a molecular epidemiologic subcohort in the Agricultural Health Study.MethodsThis analysis included 268 male farmers selected based on self-reported recent and lifetime occupational glyphosate use and 100 age- and geography-matched male nonfarmers. Concentrations of glyphosate and oxidative stress biomarkers (8-hydroxy-2′-deoxyguanosine [8-OHdG], 8-iso-prostaglandin-F2α, and malondialdehyde [MDA]) were quantified in first-morning-void urine. We performed multivariable linear regression to evaluate associations of urinary glyphosate and self-reported glyphosate use with each oxidative stress biomarker.ResultsUrinary glyphosate concentrations were positively associated with levels of 8-OHdG (highest vs lowest glyphosate quartile; geometric mean ratio = 1.15, 95% confidence interval = 1.03 to 1.28; Ptrend = .02) and MDA (geometric mean ratio = 1.20, 95% confidence interval = 1.03 to 1.40; Ptrend = .06) overall. Among farmers reporting recent glyphosate use (last 7 days), use in the previous day was also associated with statistically significantly increased 8-OHdG and MDA levels. Compared with nonfarmers, we observed elevated 8-iso-prostaglandin-F2α levels among farmers with recent, high past 12-month, or high lifetime glyphosate use.ConclusionsOur findings contribute to the weight of evidence supporting an association between glyphosate exposure and oxidative stress in humans and may inform evaluations of the carcinogenic potential of this herbicide.
Exploring the antibacterial potential of Lactococcus lactis subsp. lactis bv. diacetylactis BGBU1-4 by genome mining, bacteriocin gene overexpression, and chemical protein synthesis of lactolisterin BU variants
Authors: Malesevic Milka , Gardijan Lazar , Miljkovic Marija , O'Connor Paula M , Mirkovic Nemanja , Jovcic Branko , Cotter Paul D , Jovanovic Goran , Kojic Milan 
Published: January 2023

Abstract
Lactic acid bacterium Lactococcus lactis BGBU1-4 produces 43 amino acids (aa) long bacteriocin, lactolisterin BU (LBU), a 5.161 kDa peptide with potent antibacterial activity against many Gram-positive pathogens. In addition, BGBU1-4 produces an additional unknown product of 3.642 kDa with antibacterial activity. Here, we determined that the significant amount of naturally produced LBU breaks down to create a 3.642 kDa truncated form of LBU bacteriocin consisting of 31 N-terminal aa (LBU1-31) that exhibits 12.5% the antibacterial activity of the full-length LBU. We showed that chemically synthesized LBU is stable and 50% less active than native LBU, and so we used the synthetic peptides of LBU and its variants to further study their activities and antibacterial potential. Deletion analysis of LBU revealed that the 24 N-terminal aa of LBU (LBU1-24) are responsible for antibacterial activity, while downstream aa (25–43) determine the species-specific effectiveness of LBU. Although LBU1-31 contains aa 1–24, the truncation at position 31 is predicted to change the structure within aa 15–31 and might impact on antibacterial activity. Intriguingly, whole genome sequencing and genome mining established that BGBU1-4 is abundant in genes that encode potential antibacterials, but produces LBU and its breakdown product LBU1-31 exclusively.
The ultraviolet continuum slopes (β) of galaxies at z ≃ 8-16 from JWST and ground-based near-infrared imaging
Authors: Cullen Fergus , McLure R J , McLeod D J , Dunlop J S , Donnan C T , Carnall A C , Bowler R A A , Begley R , Hamadouche M L , Stanton T M 
Published: January 2023

ABSTRACT
We study the rest-frame ultraviolet (UV) continuum slopes (β) of galaxies at redshifts 8 &lt; z &lt; 16 (〈z〉 = 10), using a combination of JWST ERO and ERS NIRCam imaging and ground-based near-infrared imaging of the COSMOS field. The combination of JWST and ground-based imaging provides a wide baseline in both redshift and absolute UV magnitude (−22.6 &lt; MUV &lt; −17.9), sufficient to allow a meaningful comparison to previous results at lower redshift. Using a power-law fitting technique, we find that our full sample (median MUV = −19.3 ± 1.3) returns an inverse-variance weighted mean value of 〈β〉 = −2.10 ± 0.05, with a corresponding median value of β = −2.29 ± 0.09. These values imply that the UV colours of galaxies at z &gt; 8 are, on average, no bluer than the bluest galaxies in the local universe (e.g. NGC 1705; β = −2.46). We find evidence for a β − MUV relation, such that brighter UV galaxies display redder UV slopes ($\rm {d}\beta / \rm {d} M_{\rm UV} = -0.17 \pm 0.05$). Comparing to results at lower redshift, we find that the slope of our β − MUV relation is consistent with the slope observed at z ≃ 5 and that, at a given MUV, our 8 &lt; z &lt; 16 galaxies are bluer than their z ≃ 5 counterparts, with an inverse-variance weighted mean offset of 〈Δβ〉 = −0.38 ± 0.09. We do not find strong evidence that any objects in our sample display ultra-blue UV continuum slopes (i.e. β ≲ −3) that would require their UV emission to be dominated by ultra-young, dust-free stellar populations with high Lyman-continuum escape fractions. Comparing our results to the predictions of theoretical galaxy formation models, we find that the galaxies in our sample are consistent with the young, metal-poor, and moderately dust-reddened galaxies expected at z &gt; 8.
Close encounters of tight binary stars with stellar-mass black holes
Authors: Ryu Taeho , Perna Rosalba , Pakmor Ruediger , Ma Jing-Ze , Farmer Rob , de Mink Selma E 
Published: January 2023

ABSTRACT
Strong dynamical interactions among stars and compact objects are expected in a variety of astrophysical settings, such as star clusters and the disks of active galactic nuclei. Via a suite of three-dimensional hydrodynamics simulations using the moving-mesh code arepo, we investigate the formation of transient phenomena and their properties in close encounters between an $2\, {\rm M}_{\odot }$ or $20\, {\rm M}_{\odot }$ equal-mass circular binary star and single $20\, {\rm M}_{\odot }$ black hole (BH). Stars can be disrupted by the BH during dynamical interactions, naturally producing electromagnetic transient phenomena. Encounters with impact parameters smaller than the semimajor axis of the initial binary frequently lead to a variety of transients whose electromagnetic signatures are qualitatively different from those of ordinary disruption events involving just two bodies. These include the simultaneous or successive disruptions of both stars and one full disruption of one star accompanied by successive partial disruptions of the other star. On the contrary, when the impact parameter is larger than the semimajor axis of the initial binary, the binary is either simply tidally perturbed or dissociated into bound and unbound single stars (‘micro-Hills’ mechanism). The dissociation of $20\, {\rm M}_{\odot }$ binaries can produce a runaway star and an active BH moving away from one another. Also, the binary dissociation can either produce an interacting binary with the BH, or a non-interacting, hard binary; both could be candidates of BH high- and low-mass X-ray binaries. Hence, our simulations especially confirm that strong encounters can lead to the formation of the (generally difficult to form) BH low-mass X-ray binaries.
Self-consistent models of our Galaxy
Authors: Binney James , Vasiliev Eugene 
Published: January 2023

ABSTRACT
A new class of models of stellar discs is introduced and used to build a self-consistent model of our Galaxy. The model is defined by the parameters that specify the action-based distribution functions (DFs) f(J) of four stellar discs (three thin-disc age cohorts and a thick disc), spheroidal bulge and spheroidal stellar and dark haloes. From these DFs plus a specified distribution of gas, we solve for the densities of stars and dark matter and the potential they generate. The principal observational constraints are the kinematics of stars with Gaia Radial Velocity Spectrometer (RVS) data and the density of stars in the column above the Sun. The model predicts the density and kinematics of stars and dark matter throughout the Galaxy, and suggests the structure of the dark halo prior to the infall of baryons. The code used to create the model is available on github.
Atomic data on inelastic processes in boron–hydrogen collisions with accounting for fine structure
Authors: Voronov Yaroslav V , Yakovleva Svetlana A , Belyaev Andrey K 
Published: January 2023

ABSTRACT
This paper reports the results of investigations of inelastic processes in B + H and B+ + H− collisions with accounting for the fine structure. The calculations of the cross-sections and rate coefficients for excitation, de-excitation, ion-pair formation, and mutual neutralization processes (240 in total) are performed by using the quantum asymptotic method, which is modified in this paper for accounting of the fine structure, and by the multichannel approach within the framework of the Born–Oppenheimer formalism. It is found that accounting for the fine structure may change the rate coefficients significantly, and the rates calculated with accounting for the fine structure cannot be obtained by a simple redistribution of the non-relativistic rates. The processes important for non-local thermodynamic equilibrium modelling of stellar atmospheres are designated.
Consistent and simultaneous modelling of galaxy clustering and galaxy–galaxy lensing with subhalo abundance matching
Authors: Contreras Sergio , Angulo Raul E , Chaves-Montero Jonás , White Simon D M , Aricò Giovanni 
Published: January 2023

ABSTRACT
The spatial distribution of galaxies and their gravitational lensing signal offer complementary tests of galaxy formation physics and cosmology. However, their synergy can only be fully exploited if both probes are modelled accurately and consistently. In this paper, we demonstrate that this can be achieved using an extension of Sub-Halo Abundance Matching extended model (SHAMe), dubbed SHAMe. Specifically, we use mock catalogues built from the TNG300 hydrodynamical simulation to show that SHAMe can simultaneously model the multipoles of the redshift–space galaxy correlation function and galaxy–galaxy lensing, without noticeable bias within the statistical sampling uncertainties of a SDSS volume and on scales r ∈ [0.6 − 30]h−1 Mpc. Modelling the baryonic processes in galaxy–galaxy lensing with a baryonification scheme allows SHAMe’s range of validity to be extended to r ∈ [0.1 − 30] h−1 Mpc. Remarkably, our model achieves this level of precision with just five free parameters beyond those describing the baryonification model. At fixed cosmology, we find that galaxy–galaxy lensing provides a general consistency test but little additional information on galaxy modelling parameters beyond that encoded in the redshift-space multipoles. It does, however, improve constraints if only the projected correlation function is available, as in surveys with only photometric redshifts. We expect SHAMe to have a higher fidelity across a wider range of scales than more traditional methods such as Halo Occupation Distribution modelling. Thus it should provide a significantly more powerful and more robust tool for analysing next-generation large-scale surveys.
Catching a Milky Way open cluster in its last breath
Authors: Piatti Andrés E 
Published: January 2023

ABSTRACT
Theoretical models have suggested peculiar velocity dispersion profiles of star clusters facing dissolution. They predicted that, besides bound stars that still belong to the star cluster, and unbound ones already stripped off, there is an intermediate population of stars that having acquired the enough energy to escape the cluster are still within the cluster Jacobi radius. Both, potential escapers and unbound stars, show hot kinematics, not observed along tidal tails of star clusters. We report on the first evidence of an open cluster with stars crossing such a transitional scenario, namely: ASCC 92. The open cluster gathers nearly 10 per cent of its initial total mass, and is moving towards Galactic regions affected by higher interstellar absorption. Precisely, the obscured appearance of the cluster could have hampered disentangling its true internal dynamical evolutionary stage, previously.
The comptonizing medium of the black hole X-ray binary MAXI J1535−571 through type-C quasi-periodic oscillations
Authors: Rawat Divya , Méndez Mariano , García Federico , Altamirano Diego , Karpouzas Konstantinos , Zhang Liang , Alabarta Kevin , Belloni Tomaso M , Jain Pankaj , Bellavita Candela 
Published: January 2023

ABSTRACT
We present a detailed spectral and temporal analysis of the black hole candidate MAXI J1535−571 using NICER observations in 2017 September and October. We focus specifically on observations in the hard-intermediate state when the source shows type-C quasi-periodic oscillations (QPOs). We fitted the time-averaged spectrum of the source and the rms and phase-lag spectra of the QPO with a one-component time-dependent Comptonization model. We found that the corona contracts from ∼104–3× 10 3 km as the QPO frequency increases from ∼ 1.8–9.0 Hz. The fits suggest that the system would consist of two coronas, a small one that dominates the time-averaged spectrum and a larger one, possibly the jet, that dominates the rms and lag spectra of the QPO. We found a significant break in the relation between the spectral parameters of the source and the properties of the QPO, including its lag spectra, with QPO frequency. The change in the relations happens when the QPO frequency crosses a critical frequency ν c ≈ 3.0 Hz. Interestingly, the QPO reaches this critical frequency simultaneously as the radio emission from the jet in this source is quenched.
Single-cell gene regulatory network prediction by explainable AI
Authors: Keyl Philipp , Bischoff Philip , Dernbach Gabriel , Bockmayr Michael , Fritz Rebecca , Horst David , Blüthgen Nils , Montavon Grégoire , Müller Klaus-Robert , Klauschen Frederick 
Published: January 2023

AbstractThe molecular heterogeneity of cancer cells contributes to the often partial response to targeted therapies and relapse of disease due to the escape of resistant cell populations. While single-cell sequencing has started to improve our understanding of this heterogeneity, it offers a mostly descriptive view on cellular types and states. To obtain more functional insights, we propose scGeneRAI, an explainable deep learning approach that uses layer-wise relevance propagation (LRP) to infer gene regulatory networks from static single-cell RNA sequencing data for individual cells. We benchmark our method with synthetic data and apply it to single-cell RNA sequencing data of a cohort of human lung cancers. From the predicted single-cell networks our approach reveals characteristic network patterns for tumor cells and normal epithelial cells and identifies subnetworks that are observed only in (subgroups of) tumor cells of certain patients. While current state-of-the-art methods are limited by their ability to only predict average networks for cell populations, our approach facilitates the reconstruction of networks down to the level of single cells which can be utilized to characterize the heterogeneity of gene regulation within and across tumors.
The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis
Authors: Sánchez Brenda Janice , Mubaid Souad , Busque Sandrine , de los Santos Yossef Lopez , Ashour Kholoud , Sadek Jason , Lian Xian Jin , Khattak Shahryar , Di Marco Sergio , Gallouzi Imed-Eddine 
Published: January 2023

AbstractmRNA stability is the mechanism by which cells protect transcripts allowing their expression to execute various functions that affect cell metabolism and fate. It is well-established that RNA binding proteins (RBPs) such as HuR use their ability to stabilize mRNA targets to modulate vital processes such as muscle fiber formation (myogenesis). However, the machinery and the mechanisms regulating mRNA stabilization are still elusive. Here, we identified Y-Box binding protein 1 (YB1) as an indispensable HuR binding partner for mRNA stabilization and promotion of myogenesis. Both HuR and YB1 bind to 409 common mRNA targets, 147 of which contain a U-rich consensus motif in their 3′ untranslated region (3′UTR) that can also be found in mRNA targets in other cell systems. YB1 and HuR form a heterodimer that associates with the U-rich consensus motif to stabilize key promyogenic mRNAs. The formation of this complex involves a small domain in HuR (227–234) that if mutated prevents HuR from reestablishing myogenesis in siHuR-treated muscle cells. Together our data uncover that YB1 is a key player in HuR-mediated stabilization of pro-myogenic mRNAs and provide the first indication that the mRNA stability mechanism is as complex as other key cellular processes such as mRNA decay and translation.
Metabolically-targeted dCas9 expression in bacteria
Authors: Pellegrino Gregory M , Browne Tyler S , Sharath Keerthana , Bari Khaleda A , Vancuren Sarah J , Allen-Vercoe Emma , Gloor Gregory B , Edgell David R 
Published: January 2023

Abstract
The ability to restrict gene expression to a relevant bacterial species in a complex microbiome is an unsolved problem. In the context of the human microbiome, one desirable target metabolic activity are glucuronide-utilization enzymes (GUS) that are implicated in the toxic re-activation of glucuronidated compounds in the human gastrointestinal (GI) tract, including the chemotherapeutic drug irinotecan. Here, we take advantage of the variable distribution of GUS enzymes in bacteria as a means to distinguish between bacteria with GUS activity, and re-purpose the glucuronide-responsive GusR transcription factor as a biosensor to regulate dCas9 expression in response to glucuronide inducers. We fused the Escherichia coli gusA regulatory region to the dCas9 gene to create pGreg-dCas9, and showed that dCas9 expression is induced by glucuronides, but not other carbon sources. When conjugated from E. coli to Gammaproteobacteria derived from human stool, dCas9 expression from pGreg-dCas9 was restricted to GUS-positive bacteria. dCas9-sgRNAs targeted to gusA specifically down-regulated gus operon transcription in Gammaproteobacteria, with a resulting ∼100-fold decrease in GusA activity. Our data outline a general strategy to re-purpose bacterial transcription factors responsive to exogenous metabolites for precise ligand-dependent expression of genetic tools such as dCas9 in diverse bacterial species.