bluuebunny/crossref_metadata_2025_split huggingface dataset:
The neural determinants of abstract beauty
Authors: Rasche Samuel E. , Beyh Ahmad , Paolini Marco , Zeki Semir 
Published: January 2023

AbstractWe have enquired into the neural activity which correlates with the experience of beauty aroused by abstract paintings consisting of arbitrary assemblies of lines and colours. During the brain imaging experiments, subjects rated abstract paintings according to aesthetic appeal. There was low agreement on the aesthetic classification of these paintings among participants. Univariate analyses revealed higher activity with higher declared aesthetic appeal in both the visual areas and the medial frontal cortex. Additionally, representational similarity analysis (RSA) revealed that the experience of beauty correlated with decodable patterns of activity in visual areas. These results are broadly similar to those obtained in previous studies on facial beauty. With abstract art, it was the involvement of visual areas implicated in the processing of lines and colours while with faces it was of visual areas implicated in the processing of faces. Both categories of aesthetic experience correlated with increased activity in medial frontal cortex. We conclude that the sensory areas participate in the selection of stimuli according to aesthetic appeal and that it is the co‐operative activity between the sensory areas and the medial frontal cortex that is the basis for the experience of abstract visual beauty. Further, this co‐operation is enabled by “experience dependent” functional connections, in the sense that currently the existence and high specificity of these connections can only be demonstrated during certain experiences.
Microbiological status at intake in relation to clinical periodontal status at intake and the response to non‐surgical periodontal therapy—A retrospective analysis
Authors: Tahery Ilias , Ahmadzai Fardin , Valkenburg Cees , Slot Dagmar E. , Van der Weijden Fridus (G. A.) 
Published: January 2023

AbstractAimRetrospective analysis of subgingival microbiological data at intake in relation to the clinical periodontal status at intake and following non‐surgical periodontal treatment.Materials and MethodsData were obtained from a population that consisted of patients diagnosed with moderate‐to‐severe periodontitis who had undergone non‐surgical periodontal treatment between 2016 and 2020. The presence and number of eight selected putative periodontal pathogens [Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Tannerella forsythia (Tf), Parvimonas micra (Pm), Fusobacterium nucleatum (Fn), Treponema denticola (Td) and Filifactor alocis (Fa)] at intake and the percentage of teeth and sites with PPD >5 mm at intake and after treatment were extracted. Correlations within collected data were analysed with adjustment for multiple comparisons. Sub‐analyses were performed based on gender, age, and smoking and diabetic status.ResultsSix hundred and sixty‐one patients could be included. The percentage of teeth with PPD >5 mm and the percentage of sites with PPD >5 mm at intake were significantly correlated to Pi, Tf, Pm, Fn and Fa. Patients with higher numbers of these pathogens at intake had a better treatment response. Those patients with higher numbers of Aa had a lower percentage of teeth and sites with PPD >5 mm at intake. Those with higher numbers of Aa also showed a smaller decrease in the percentage of sites with PPD >5 mm.ConclusionThe clinical periodontal status at intake and the response to treatment showed a weak but significant positive relationship for Pi, Tf, Pm, Fn and Fa. Conversely, higher numbers of Aa at intake were associated with more localized periodontitis and a reduced treatment response.
Ostracizing sources avoid communal tastes: Effect of ostracizing behaviour on extraordinary consumption
Authors: Park Eujin , Lee Sue Hyun 
Published: January 2023

AbstractAlthough people often exclude others in their daily encounters and social media interactions, no consumer research on ostracism has solely focused on sources of ostracism. We argue that the influence of ostracism on evasive behaviour is worth investigating since the scant academic investigations on sources are limited to their reparation intentions for their harmful behaviour. Three experiments were conducted to examine the influence of ostracizing behaviour (vs. neutral vs. social interaction) on extraordinary consumption in face‐to‐face and social media contexts. It was uncovered that sources sense dissonant feelings in dissimilar contexts when their behaviour transcends society's normative boundaries and, hence, prefer consumption that does not commonly appear in society as a means to evade this dissonance. The effect was moderated by sources' justification of their behaviour. We initiate consumer research on sources of ostracism and contribute to the marketing practice of introducing extraordinary consumption options by investigating the psychological consequences of ostracizing behaviour.
Cross‐sectional and longitudinal associations between family meals frequency and children's overweight/obesity in families at high risk of type 2 diabetes: The Feel4Diabetes‐study
Authors: Mahmood Lubna , Gonzalez‐Gil Esther M. , Makrilakis Konstantinos , Liatis Stavros , Schwarz Peter , Herrmann Sandra , Willems Ruben , Cardon Greet , Latomme Julie , Rurik Imre , Radó Sándorné , Iotova Violeta , Usheva Natalya , Tankova Tsvetalina , Karaglani Eva , Manios Yannis , Moreno Luis A. ,   the Feel4Diabetes‐Study Group
Published: January 2023

SummaryBackgroundThe frequency of family meals has been suggested as a protective factor against obesity among children.ObjectiveThis study aimed to investigate the cross‐sectional and longitudinal associations between family meals frequency and children's overweight/obesity in families at high risk of type 2 diabetes (T2D) across six European countries.Methods989 parent–child dyads (52% girls and 72% mothers) were included. Participants completed validated measures to assess the frequency of family meals and anthropometrics. Multivariable regression models were applied to examine the longitudinal associations between family meals frequency and overweight/obesity in children. Logistic regression was performed to predict the odds of having overweight/obesity depending on changes in family meals frequency over a two‐year follow‐up period. Analyses were stratified for children's sex.ResultsHigh frequency of family breakfasts and/or dinners was inversely associated with children's BMI in boys and girls at T2. Results showed decreased odds of overweight/obesity at follow‐up among both boys (OR = 0.65; 95% CI 0.41, 0.96) and girls (OR = 0.53; 95% CI 0.31, 0.87) who consumed minimum of three times family breakfasts and/or family dinners a week at baseline. An increase in family breakfasts and/or dinners frequency was associated with lower odds of overweight/obesity in both boys and girls at follow‐up.ConclusionA high frequency of family breakfasts and/or dinners but not lunch during childhood is associated with lower odds of overweight/obesity development in children from families at high risk of T2D. The promotion of family meals could help in preventing the development of overweight/obesity among children.
Molecular identification of glutathione S‐transferase genes and their potential roles in insecticides susceptibility of Grapholita molesta
Authors: Zhang Songdou , Zhang Dongyue , Jia Yujie , Li Jianying , Li Zhen , Liu Xiaoxia 
Published: January 2023

AbstractGrapholita molesta is one kind of serious fruit‐boring pests in the world, which caused huge economic losses to the fruit industry including pear and apple. The heavy usage of synthetic insecticides resulted in different degrees of resistance of G. molesta to some commonly used insecticides. However, the tolerance mechanisms of G. molesta to insecticides are still unclear. Glutathione S‐transferases (GSTs) belong to the superfamily of detoxifying enzymes and mainly play important roles in detoxification metabolism and insecticide susceptibility of insects. In this study, we first evaluated the toxicity of three insecticides including emamectin benzoate, chlorantraniliprole and lambda‐cyhalothrin on G. molesta at different developmental stages. Synergism study showed that the susceptibility of G. molesta larvae to these three insecticides obviously increased when the enzyme activity of GST was inhibited by diethyl maleate compared with the controls. Next, we screened out six GmGST genes which are upregulated after insecticides treatment from a total of 21 GmGST genes and analysed their sequence characteristics and expression profiles. RNAi and bioassay results further revealed that the mortality of 5th instar larvae significantly increased after exposure to LC30 of emamectin benzoate, chlorantraniliprole and lambda‐cyhalothrin when silencing of GmGSTo2, GmGSTs1 and GmGSTz1 compared with the controls. In conclusion, this study indicated that GmGSTo2, GmGSTs1 and GmGSTz1 play important roles in insecticides susceptibility of G. molesta to three commonly used insecticides, which is significance for its future integrated management.
Construction a novel detection method for Trichomonas vaginalis based on recombinant enzyme polymerase amplification targeting the Actin gene
Authors: Li Fakun , Deng Yangyang , Sheng Wanxin , Gao Xihui , Wang Weijuan , Chu Zhili , Mei Xuefang , Yang Zhenke , Tian Xiaowei , Wang Shuai , Zhang Zhenchao 
Published: January 2023

AbstractTrichomoniasis is a common and curable sexually transmitted disease worldwide. The rapid, convenient, and accurate diagnosis of trichomoniasis is an important link in the prevention and treatment of the disease. The current detection methods of Trichomonas vaginalis are mainly wet mount microscopy, culture, nested PCR, and loop‐mediated isothermal amplification. However, these detection methods have some shortcomings. In this study, a recombinant enzyme polymerase amplification (RPA) assay had been conducted to detect T. vaginalis. The target gene and the corresponding primers were screened, and the reaction system and conditions were optimized in the assay of RPA. The sensitivity and specificity of this detection method were analyzed. The detection efficiency of wet mount microscopy, culture, nested PCR, and RPA was compared by testing 53 clinical samples from vaginal secretions. By screening, the actin gene of T. vaginalis could be used as a target gene for RPA detection of T. vaginalis, and the optimum reaction condition to amplify the actin gene by RPA was at 39°C for 30 min. The detection limit of T. vaginalis DNA using RPA was 1 pg, corresponding to a sensitivity of approximately five trophozoites. The RPA assay demonstrated high specificity for T. vaginalis, and there was no cross‐reactivity with Giardia lamblia, Escherichia coli, Lactobacillus, Toxoplasma gondii, Staphylococcus aureus, and Candida albicans. Of the 53 clinical samples, the positive rates of T. vaginalis detected by wet mount microscopy, culture, nested PCR and RPA were 50.9 4% (27/53), 71.7% (38/53), 71.7% (38/53), and 69.81% (37/53), respectively. Compared with culture which was used as the gold standard for diagnosing trichomoniasis, testing clinical samples by wet mount microscopy showed 71.05% sensitivity, 100% specificity, and moderate diagnostic agreement with the culture (K = 0.581, Z = 4.661, p < 0.001). The nested PCR showed 100% sensitivity, 100% specificity, and excellent diagnostic agreement (K = 1, Z = 7.28, p < 0.001), while RPA displayed 97.37% sensitivity, 100% specificity, and excellent diagnostic agreement (K = 0.954, Z = 6.956, p < 0.001). At the present study, rapid amplification of actin gene by RPA could be used as a tool for detection of T. vaginalis. The detection method of RPA was more sensitive than wet mount microscopy and displayed excellent specificity. Moreover, RPA amplification of actin gene did not require a PCR instrument and the amplification time was shorter than that of ordinary PCR. Therefore, the RPA assay was proposed in this study as a point‐of‐care examination and a diagnostic method of T. vaginalis infection, which exhibited the potential value in the treatment and prevention of trichomoniasis.
Differential response of RTGUTGC and RTGILL‐W1 rainbow trout epithelial cell lines to viral stimulation
Authors: Simón Rocío , Martínez Patricia , González Lucía , Ordás M. Camino , Tafalla Carolina 
Published: January 2023

AbstractMucosal surfaces constitute the main route of entry of pathogens into the host. In fish, these mucosal tissues include, among others, the gastrointestinal tract, the gills and the skin. However, knowledge about the mechanisms of regulation of immunity in these tissues is still scarce, being essential to generate a solid base that allows the development of prevention strategies against these infectious agents. In this work, we have used the RTgutGC and RTgill‐W1 epithelial‐like cell lines, derived from the gastrointestinal tract and the gill of rainbow trout (Oncorhynchus mykiss), respectively, to investigate the transcriptional response of mucosal epithelial cells to a viral mimic, the dsRNA poly I:C, as well as to two important viral rainbow trout pathogens, namely viral haemorrhagic septicaemia virus (VHSV) and infectious pancreatic necrosis virus (IPNV). Additionally, we have established how the exposure to poly I:C affected the susceptibility of RTgutGC and RTgill‐W1 cells to both viruses. Our results reveal important differences in the way these two cell lines respond to viral stimuli, providing interesting information on these cell lines that have emerged in the past years as useful tools to study mucosal responses in fish.
The associations between paranormal beliefs and sleep variables
Authors: Rauf Betul , Perach Rotem , Madrid‐Valero Juan J. , Denis Dan , Sharpless Brian A. , Poerio Giulia Lara , French Christopher C. , Gregory Alice M. 
Published: January 2023

SummaryPrevious studies have found significant associations between paranormal beliefs and sleep variables. However, these have been conducted on a small scale and are limited in the number of sleep variables investigated. This study aims to fill a gap in the literature by investigating paranormal beliefs in relation to a wide range of sleep variables in a large sample. Participants (N = 8853) completed a survey initiated by the BBC Focus Magazine. They reported on their demographics, sleep disturbances and paranormal beliefs. Poorer subjective sleep quality (lower sleep efficiency, longer sleep latency, shorter sleep duration and increased insomnia symptoms) was associated with greater endorsement of belief in: (1) the soul living on after death; (2) the existence of ghosts; (3) demons; (4) an ability for some people to communicate with the dead; (5) near‐death experiences are evidence for life after death; and (6) aliens have visited earth. In addition, episodes of exploding head syndrome and isolated sleep paralysis were associated with the belief that aliens have visited earth. Isolated sleep paralysis was also associated with the belief that near‐death experiences are evidence for life after death. Findings obtained here indicate that there are associations between beliefs in the paranormal and various sleep variables. This information could potentially better equip us to support sleep via psychoeducation. Mechanisms underlying these associations are likely complex, and need to be further explored to fully understand why people sometimes report “things that go bump in the night”.
Using simulations to explore the potential effect of disease and inflammation on the frequency of violative flunixin residues in cattle
Authors: Greene Jonathan M. , Martinez Marilyn N. 
Published: January 2023

AbstractThe US Food and Drug Administration (FDA) assigns a tolerance and withdrawal period when evaluating new drugs for use in food‐producing species. Because withdrawal periods are determined from data generated in normal, healthy animals, questions have been raised regarding whether disease and inflammation can be a factor associated with some residue violations. We explored this question using flunixin liver concentrations as a model situation. Using data contained in the flunixin FOI Summary (NADA 101‐479) and Monte Carlo simulation, we generated sets of residue depletion data. Our mathematical model was simple linear regression containing the terms alpha (the marker residue back‐extrapolated to time zero, which equals ) and beta (the elimination rate constant which equals ). By modifying alpha and beta means and variances, we determined the smallest change in these parameters that would result in the presence of violative residues above the statistically determined expected frequency of 1%. The results of this in silico study indicated that the magnitude of change in alpha and beta needed to generate violative residues exceeds that likely to occur due to disease or inflammation when flunixin is used in accordance with the approved product label.
Twenty years of experimental philosophy research
Authors: Li Jincai , Zhu Xiaozhen 
Published: January 2023

AbstractThis paper reports the first study in the literature that adopts a bibliometric approach to systematically explore the scholarship in the young and fast‐growing research field of experimental philosophy. Based on a corpus of 1,248 publications in experimental philosophy from the past two decades retrieved from the PhilPapers website, the study examined the publication trend, the influential experimental philosophers, the impactful works, the popular publication venues, and the major research themes in this subarea of philosophy. It found, first, an overall growing trend in publications in experimental philosophy, encompassing four developmental stages. Second, it found that significant changes in topics of interest have taken place, with some gaining increasing attention, others seemingly going out of fashion, and still others remaining popular constantly. Third, the study identified lists of leading philosophers, frequently cited publications, and popular journals helpful for researchers and newcomers to get a quick start in learning about the field.
Dysfunctional breathing and its impact on asthma control in children and adolescents
Authors: Vahlkvist Signe , Jürgensen Louise , Hell Tine Detlefsen , Petersen Thomas Houmann , Kofoed Poul‐Erik 
Published: January 2023

AbstractBackgroundDysfunctional breathing (DB) has been shown to negatively affect asthma control in adults, but for children and adolescents, the knowledge is scarce. DB is among others characterized by dyspnea and hyperventilation. The Nijmegen Questionnaire (NQ) is often used as a marker for DB. We conducted a cross‐sectional survey to estimate the prevalence of DB in patients with asthma in a pediatric outpatient clinic and to determine the impact of DB on asthma control.MethodsPatients between 10 and 17 years were invited to complete the NQ and the Asthma Control Questionnaire (ACQ) and report the use of beta2 agonist (β2). Spirometry data and prescribed asthma medications were noted from the patient record.ResultsThree hundred and sixty‐three patients (180 boys) completed the survey. Sixty‐seven patients (18%) scored ≥23 points in the NQ predicting DB. The DB group was older (median (range)) 15.6 (10.5–17.9) vs. 13.7 (10.0–17.9) years) (p < .01), and girls were overrepresented (84%) (p < .01). FEV1% exp. was higher in the DB group (mean (SD)) (89.4 (9.0) vs. 85.7 (11.8)) (p < .02). ACQ score (median (range)) (2.0 (0–4) vs. 0.6 (0–3.4)) (p < .01) and the use of β2 (median (range)) (2 (0–56) vs. 0 (0–20) puffs/week) (p < .01) were higher. Inhaled corticosteroid dose (mean (SD) (416 (160) vs. 420 (150) mcg) and the use of a second controller were equal between the groups.ConclusionDysfunctional breathing was a frequent comorbidity, especially in adolescent girls. DB correlated with poorer asthma control and higher use of β2 and may be an important cofactor in difficult‐to‐treat asthma.
Interdependence between online peer‐to‐peer lending and cryptocurrency markets and its effects on financial inclusion
Authors: Chung Sunghun , Kim Keongtae , Lee Chul Ho , Oh Wonseok 
Published: January 2023

Online peer‐to‐peer (P2P) lending has emerged as an innovative financial technology (FinTech) platform that renders financial services that are potentially more inclusive and affordable than those offered by traditional financial institutions. A similar purpose is served by cryptocurrency markets, where transaction costs are reduced and financial accessibility is improved based on disruptive technologies such as blockchain and distributed ledgers. Despite these developments, however, in the operations management literature limited attention has been devoted to the contribution of online P2P lending to the promotion of financial inclusion (i.e., the availability and usage of financial services for all groups of people) and its dynamic interplay with cryptocurrency markets. The rise of cryptocurrency markets affects the composition and activity of borrowers and investors in P2P lending markets and hence the capacity of the latter to support financial inclusion, leading to an operations management challenge in online P2P lending. We examine how cryptocurrency markets influence P2P lending markets' democratization of access to financial services, particularly P2P borrowing. To investigate these effects in depth, we develop a simple theoretical model to derive testable propositions, which are then empirically validated on the basis of unique data sets. We find that the growth in cryptocurrency markets is associated with increased loan requests and larger loan amounts in P2P markets, especially from borrowers who maintain good credit ratings, possess technical knowledge about cryptocurrencies, and intend to borrow for investment purposes. Our results suggest that cryptocurrency markets bring economic gains to the P2P lending market, at least in the short term. Nonetheless, the transfer of funds from P2P lending to cryptocurrency markets, particularly by highly creditworthy and tech‐savvy investors, may provoke increased inequality in access to P2P lending markets. By scrutinizing the interdependence between two representative FinTech markets we uncover important operations management implications for theory and practice regarding the healthy growth and effective governance of crowdfunding platforms and the corresponding sustainability of their role in upholding financial inclusion.
Phenotypes of cyclic nucleotide‐gated cation channel mutants: probing the nature of native channels
Authors: Ma Yi , Garrido Keila , Ali Rashid , Berkowitz Gerald A. 
Published: January 2023

SUMMARYPlant cyclic nucleotide gated channels (CNGCs) facilitate cytosolic Ca2+ influx as an early step in numerous signaling cascades. CNGC‐mediated Ca2+ elevations are essential for plant immune defense and high temperature thermosensing. In the present study, we evaluated phenotypes of CNGC2, CNGC4, CNGC6, and CNGC12 null mutants in these two pathways. It is shown CNGC2, CNGC4, and CNGC6 physically interact in vivo, whereas CNGC12 does not. CNGC involvement in immune signaling was evaluated by monitoring mutant response to elicitor peptide Pep3. Pep3 response cascades involving CNGCs included mitogen‐activated kinase activation mediated by Ca2+‐dependent protein kinase phosphorylation. Pep3‐induced reactive oxygen species generation was impaired in cngc2, cngc4, and cngc6, but not in cngc12, suggesting that CNGC2, CNGC4, and CNGC6 (which physically interact) may be components of a multimeric CNGC channel complex for immune signaling. However, unlike cngc2 and cngc4, cngc6 is not sensitive to high Ca2+ and displays no pleiotropic dwarfism. All four cngc mutants showed thermotolerance compared to wild‐type, although CNGC12 does not interact with the other three CNGCs. These results imply that physically interacting CNGCs may, in some cases, function in a signaling cascade as components of a heteromeric channel complex, although this may not be the case in other signaling pathways.