bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food availability influences angling vulnerability in muskellunge
Authors: Bieber John F. , MacDougall‐Shackleton Scott A. , Suski Cory D. 
Published: September 2023

AbstractReduced food availability increases the capture of several fish species, although the mechanisms responsible for how food resources result in increased capture are undefined. Our objective was to quantify the mechanism by which food availability might influence the angling vulnerability of muskellunge (Esox masquinongy). We assessed capture rates in the field under different food levels, quantified the behaviors of muskellunge that were either fed or food deprived, and determined if appetite‐related hormones leptin and ghrelin affected fish behavior. Catch rates of fasted muskellunge were more than twice as high as those of fed muskellunge. However, food deprivation and hormonal treatments did not influence laboratory behavior, which suggested that catch rates of food‐deprived muskellunge increased because fish were more receptive to lures. Furthermore, an ecosystem approach should be used to consider forage as a component of management goals.
Phosphorus nutrition strategies in a Symbiodiniacean species: Implications in coral‐alga symbiosis facing increasing phosphorus deficiency in future warmer oceans
Authors: Li Jiashun , Zhang Kaidian , Li Ling , Wang Yujie , Lin Senjie 
Published: September 2023

AbstractCoral reefs thrive in the oligotrophic ocean and rely on symbiotic algae to acquire nutrients. Global warming is projected to intensify surface ocean nutrient deficiency and anthropogenic discharge of wastes with high nitrogen (N): phosphorus (P) ratios can exacerbate P nutrient limitation. However, our understanding on how symbiotic algae cope with P deficiency is limited. Here, we investigated the responses of a coral symbiotic species of Symbiodiniaceae, Cladocopium goreaui, to P‐limitation by examining its physiological performance and transcriptomic profile. Under P stress, C. goreaui exhibited decreases in algal growth, photosynthetic efficiency, and cellular P content but enhancement in carbon fixation, N assimilation, N:P ratio, and energy metabolism, with downregulated expression of carbohydrate exporter genes. Besides, C. goreaui showed flexible mechanisms of utilizing different dissolved organic phosphorus to relieve P deficiency. When provided glycerol phosphate, C. goreaui hydrolyzed it extracellularly to produce phosphate for uptake. When grown on phytate, in contrast, C. goreaui upregulated the endocytosis pathway while no dissolved inorganic phosphorus was released into the medium, suggesting that phytate was transported into the cell, potentially via the endocytosis pathway. This study sheds light on the survival strategies of C. goreaui and potential weakening of its role as an organic carbon supplier in P‐limited environments, underscoring the importance of more systematic investigation on future projections of such effects.
Climate cooling benefits of cellulosic bioenergy crops from elevated albedo
Authors: Lei Cheyenne , Chen Jiquan , Robertson G. Philip 
Published: September 2023

AbstractChanges in land surface albedo can alter ecosystem energy balance and potentially influence climate. We examined the albedo of six bioenergy cropping systems in southwest Michigan USA: monocultures of energy sorghum (Sorghum bicolor), switchgrass (Panicum virgatum L.), and giant miscanthus (Miscanthus × giganteus), and polycultures of native grasses, early successional vegetation, and restored prairie. Direct field measurements of surface albedo (αs) from May 2018 through December 2020 at half‐hourly intervals in each system quantified the magnitudes and seasonal differences in albedo (∆α) and albedo‐induced radiative forcing (RF∆α). We used a nearby forest as a historical native cover type to estimate reference albedo and RF∆α change upon original land use conversion, and a continuous no‐till maize (Zea mays L.) system as a contemporary reference to estimate change upon conversion from annual row crops. Annually, αs differed significantly (p < 0.05) among crops in the order: early successional (0.288 ± 0.012SE) >> miscanthus (0.271 ± 0.009) ≈ energy sorghum (0.270 ± 0.010) ≥ switchgrass (0.265 ± 0.009) ≈ restored prairie (0.264 ± 0.012) > native grasses (0.259 ± 0.010) > maize (0.247 ± 0.010). Reference forest had the lowest annual αs (0.134 ± 0.003). Albedo differences among crops during the growing season were also statistically significant, with growing season αs in perennial crops and energy sorghum on average ~20% higher (0.206 ± 0.003) than in no‐till maize (0.184 ± 0.002). Average non‐growing season (NGS) αs (0.370 ± 0.020) was much higher than growing season αs (0.203 ± 0.003) but these NGS differences were not significant. Overall, the original conversion of reference forest and maize landscapes to perennials provided a cooling effect on the local climate (RFαMAIZE: −3.83 ± 1.00 W m−2; RFαFOREST: −16.75 ± 3.01 W m−2). Significant differences among cropping systems suggest an additional management intervention for maximizing the positive climate benefit of bioenergy crops, with cellulosic crops on average ~9.1% more reflective than no‐till maize, which itself was about twice as reflective as the reference forest.
Safety, tolerability, and effectiveness of repetitive intravenous dihydroergotamine for refractory chronic migraine with cardiovascular risk factors: A retrospective study
Authors: Wang Victor S. , Kosman Justin , Yuan Hsiangkuo , Lauritsen Clinton , Shrewsbury Stephen , Aurora Sheena K. , Hopkins Mary , Silberstein Stephen 
Published: September 2023

AbstractBackgroundDihydroergotamine (DHE), like triptans, is contraindicated in patients with ischemic heart disease or coronary vasospasm. Its true safety, tolerability, and efficacy in patients with cardiovascular risk without ischemic heart disease or coronary vasospasm remain unclear.ObjectivesTo assess the safety, tolerability, and effectiveness of repetitive intravenous DHE in patients with cardiovascular risk factors.MethodsA single‐center, retrospective cohort study was conducted at the Jefferson Headache Center inpatient unit for refractory chronic migraine patients treated with our intravenous DHE protocol between January 1, 2019, and October 15, 2019. We evaluated tolerability and effectiveness outcomes based on atherosclerotic cardiovascular disease 10‐year calculated risk scores, stratified into low (<5.0%) and elevated (≥5.0%) risk. Data were presented in mean ± standard deviation or median (25th percentile, 75th percentile) if non‐normally distributed.ResultsAmong 347 patients (median age of 46 [36, 57], femalen = 278 [80.1%]), who received inpatient intravenous DHE, 227 patients (age 53 [45, 60], female 81.1%) had calculable risk scores, 64 (28.2%) had elevated risk, and 38 (16.7%) had cardiology consultations. There were no clinically significant electrocardiogram abnormalities or cardiovascular adverse events. The median hospital length of stay was 6 (5, 7) days. Compared to the low‐risk group, those with elevated risk had higher nausea (31.3% vs. 14.1%,p = 0.008), but similar initial DHE dose (0.5 [0.25, 0.5] vs. 0.5 [0.25, 0.5],p = 0.009), lower final DHE dose (0.75 [0.5, 1] vs. 1 [0.75, 1]p < 0.001), and lower pain reduction after admission (−3.8 [2.1, 6] vs. −5 [3, 7]p = 0.037).ConclusionPatients receiving intravenous DHE by the Jefferson Headache Center inpatient headache protocol had significantly reduced pain severity at discharge. No clinically significant cardiac or electrocardiogram abnormalities were detected in patients with elevated (or low) atherosclerotic cardiovascular disease risk. Repetitive intravenous DHE used by our protocol was safe in refractory chronic migraine patients.
Significance of the autoantibody assay in predicting the development of immune‐related adverse events in patients receiving atezolizumab plus bevacizumab combination therapy for unresectable hepatocellular carcinoma
Authors: Takada Hitomi , Yamashita Koji , Osawa Leona , Komiyama Yasuyuki , Muraoka Masaru , Suzuki Yuichiro , Sato Mitsuaki , Kobayashi Shoji , Yoshida Takashi , Takano Shinichi , Maekawa Shinya , Enomoto Nobuyuki 
Published: September 2023

AbstractAimAtezolizumab plus bevacizumab (AB) combination therapy is the first‐line treatment for unresectable hepatocellular carcinoma (u‐HCC). The management of immune‐related adverse events (irAEs) is an important issue associated with achieving a good therapeutic response in patients receiving AB therapy. However, few studies have reported irAE development in patients receiving AB therapy. This study focused on the association between irAE development and autoantibodies at baseline in patients receiving AB therapy.MethodsSixty‐one patients receiving AB therapy were enrolled. For autoantibodies, the following antibodies were tested before the start of AB therapy: antinuclear antibodies, rheumatoid factor (RF), anti‐thyroglobulin antibodies, thyroid peroxidase antibodies, anti‐thyroid stimulating hormone receptor antibodies, and acetylcholine receptor antibodies. A patient was considered to have pre‐existing antibodies if any of the listed antibodies were present at baseline.ResultsTen patients (16%) developed irAEs during the observation period. The irAEs included liver injury, hypothyroidism, adrenal insufficiency, adrenocorticotropic hormone deficiency, and rhabdomyolysis. Patients with irAE (n = 10) were more likely to be positive for any autoantibody (hazard ratio [HR] 3.7, p = 0.047) and RF at baseline (HR 5.4, p = 0.035) and to achieve complete response (HR 5.8, p = 0.027) than those without. The presence of autoantibodies at baseline was an independent factor associated with irAE development.ConclusionIn the real world, 16% of patients receiving AB therapy for u‐HCC developed irAEs. Patients with autoantibodies at baseline are at high risk of developing irAEs and require cautious follow‐up.
The HUSH Project: Using codesign to reduce sleep disruptions for patients in hospital
Authors: Adams Corey , Walpola Ramesh , Schembri Anthony , Harrison Reema 
Published: September 2023

AbstractBackgroundPoor quality sleep in hospitals may be problematic for patients, negatively impacting their recovery and wellbeing. This project aimed to investigate the effectiveness of codesign in addressing key issues affecting sleep disruption in the healthcare setting.MethodsCodesign with patients, staff and consumer representatives was conducted in an acute metropolitan tertiary public hospital in Sydney, Australia. Through a four‐stage process, a multimodal intervention to address and reduce the impact of sleep disruptions among hospital inpatients was created. Pre‐ and post‐intervention evaluation was used to determine changes in patient‐reported sleep disruption.Results‘The HUSH Project’ (Help Us Support Healing) intervention resulted from the codesign process, which included the provision of HUSH Sleep Packs (with earplugs, eye masks and herbal tea), patient information resources, and ward‐based Sleep Champions. Survey data from 210 patients revealed a statistically significant decrease in patient‐reported noise disturbances for patients in shared rooms following the 4‐week intervention period of the HUSH program.ConclusionThe HUSH Project demonstrated that a novel multimodal intervention may be valuable in reducing sleep disruption in hospitals. These findings also indicate the benefits of using codesign methodology to support improvement projects that seek to enhance patient experiences of care.Patient or Public ContributionThis project utilised codesign methodology, which involved significant contributions from patients and consumer representatives, from research conceptualisation into intervention design, implementation and project evaluation.
Improvement effect of different protein powder on cooking characteristics of gluten‐free pasta and the establishment of quality evaluation based on principal component analysis
Authors: Zhao Renjie , Zhao Ruixuan , Li Qingyao , Li Kang , Liu Qiannan , Liu Wei , Hu Honghai 
Published: September 2023

SummaryImproving the edible quality and nutrition of gluten‐free (GF) products is vital for patients to improve their coeliac disease (CD). This study explored the effect of the addition of soybean protein isolate (SPI), ovalbumin (OVA), and whey protein (WP) on the cooking characteristics of rice‐maize‐potato (RMP) GF pasta and made a comprehensive evaluation of the quality of GF pasta. The addition of SPI at higher concentrations would seriously increase the cooking loss of GF pasta. In contrast, the addition of OVA and WP could improve the cooking stability of GF pasta. The amount of OVA and WP powder in GF flour was positively correlated with gelatinization and gel stability, and negatively correlated with cooking loss. Moreover, the addition of OVA to GF flour improved the chewiness, hardness, elasticity and tensile properties of GF pasta based on texture profile analysis. Furthermore, 13 GF pasta with different additions of protein powder were studied based on principal component analysis to evaluate the comprehensive quality of GF pasta. The consistent results of GF pasta cooking characteristics and their ranking in comprehensive quality evaluation verified the reliability of this method. This study provides a reasonable instruction for quality improvement of GF pasta and a theoretical basis for the comprehensive quality evaluation of GF pasta, which could facilitate the development of foods with high cooking characteristics and nutrition suitable for patients with CD.
Risk factors for adverse outcomes after pediatric pyeloplasty: A retrospective cohort study
Authors: Zouari Mohamed , Dghaies Rim , Rhaiem Wiem , Belhajmansour Manel , Krichen Emna , Hamad Amel Ben , Boukattaya Mariem , Dhaou Mahdi Ben , Mhiri Riadh 
Published: September 2023

PurposeTo identify the risk factors for adverse outcomes after pediatric pyeloplasty.MethodsWe conducted a retrospective review of all children under the age of 14 years who underwent primary pyeloplasty for unilateral ureteropelvic junction (UPJ) obstruction at a single teaching hospital in Tunisia between January 1, 2013, and December 31, 2022.ResultsA total of 103 patients were included. Median age of patients at surgery was 27 months (interquartile range [IQR], 13–44). On ultrasound, median renal pelvic anteroposterior diameter was 3.2 cm (IQR, 2.3–4), and the median renal cortex thickness (RCT) was 2.5 mm (IQR, 2–3.5). Median differential renal function (DRF) on preoperative radionuclide renal scan was 40% (IQR, 30–46). Postoperative adverse outcomes occurred in 28 patients (27.2%). These included 19 cases of urinary tract infections (UTIs), 11 cases of UPJ restenosis, four cases of UPJ leakage, two cases of urinoma, and two cases of diversion‐related complications. Multivariate logistic regression analysis revealed two factors significantly and independently related to postoperative negative outcomes: RCT <3 mm and DRF > 50%.ConclusionOur study demonstrated that preoperative RCT on ultrasound of less than 3 mm and preoperative DRF on radionuclide renal scan of more than 50% were independent risk factors for adverse outcomes following pediatric pyeloplasty. These factors could be of interest in identifying, early on, patients who will develop postoperative negative outcomes, giving them more attention and support, and explaining the prognosis to the patient and family.
Effect of minimally invasive versus conventional aortic root replacement on transfusion and postoperative wound complications in patients: A meta‐analysis
Authors: Chen Yu , Yu Wenbo , Jiang Yue , Gao Jianfeng , Xie Dilin , Yu Junjian , Li Wentong , Liu Ziyou , Xiong Jianxian 
Published: September 2023

AbstractWe examined whether small incision aortic root replacement could reduce the amount of blood transfusion during operation and the risk of postoperative complications. An extensive e‐review of the 4 main databases (PubMed, Cochrane, Web of Science and EMBASE) was carried out to determine all the published trials by July 2023. The search terms used were associated with partial versus full sternotomy and aortic root. This analysis only included the study articles that compared partial and full sternotomy. After excluding articles based on titles or abstracts, selected full‐text articles had reference lists searched for any potential further articles. We analysed a total of 2167 subjects from 10 comparable trials. The minimally invasive aortic root graft in breastbone decreased the duration of hospitalization (MD, −2.58; 95% CI, −3.15, −2.01, p < 0.0001) and intraoperative red blood cell transfusion (MD, −1.27; 95% CI, −2.34, −0.19, p = 0.02). However, there were no significant differences in wound infection (OR, 0.88; 95% CI, 0.16, 4.93, p = 0.88), re‐exploration for bleeding (OR, 0.96; 95% CI, 0.60, 1.53, p = 0.86), intraoperative blood loss (MD, −259.19; 95% CI, −615.11, 96.73, p = 0.15) and operative time (MD, −7.39; 95% CI, −19.10, 4.32, p = 0.22); the results showed that the microsternotomy did not differ significantly from that of the routine approach. Small sternotomy may be an effective and safe substitute for the treatment of the aorta root. Nevertheless, the wide variety of data indicates that larger, well‐designed studies are required to back up the current limited literature evidence showing a benefit in terms of complications like postoperative wound infections or the volume of intraoperative red blood cell transfusion.
Subspecies‐level distribution maps for birds of the Amazon basin and adjacent areas
Authors: Rego Marco Antonio , Del‐Rio Glaucia , Brumfield Robb T. 
Published: September 2023

AbstractAimDistribution maps for Amazonian birds are often limited to species‐level taxonomy even though many subspecies represent biological species. We provide digital maps depicting subspecies‐level distributions of Neotropical birds in the Amazonas River basin and adjoining areas.LocationAmazon region, which includes the entire Amazon basin, the east slope of the tropical Andes, French Guiana, Suriname, Guyana, south Venezuela (Bolivar and Amazonas departments), parts of the Brazilian Cerrado and the Araguaia‐Tocantins basin.TaxonBirds (Class Aves).MethodsTo build the distribution maps, we compiled a point‐locality database of 620,000 records, 90% of which represent specimens vouchered in research collections. After manually cleaning and optimising the quality of the point localities, we generated extent‐of‐occurrence polygons at the subspecies level using a concave hull function. We corrected each polygon based on the literature and expert knowledge. We used this data set to define zoogeographical regions based on multidimensional scaling and clustering analyses, and then compared subspecies‐defined regions to zoogeographic regions inferred from species‐level data.ResultsWe inferred range polygons for 3990 subspecies, representing 2043 species from 65 families. The average distribution size was 955,739 km2, with half of the taxa having range sizes smaller than 230,484 km2 (median value) and nearly one‐quarter of all subspecies having ranges smaller than 50,000 km2. We identified 10 zoogeographical regions from the subspecies data set in comparison with four areas based on a species‐level analysis of the same data. The 10 zoogeographical regions are largely congruent with previously identified areas of endemism.Main ConclusionsThe new maps of Amazonian bird subspecies distributions allow biodiversity studies (e.g. macroecology, evolution, and conservation) to be conducted at the subspecies level, and facilitate biogeographic, ecological, evolutionary and conservation research on birds in the most biologically diverse region in the world.
Biological knowledge shortfalls impede conservation efforts in poorly studied taxa—A case study of Laboulbeniomycetes
Authors: Haelewaters Danny , Matthews Thomas J. , Wayman Joseph P. , Cazabonne Jonathan , Heyman Felix , Quandt C. Alisha , Martin Thomas E. 
Published: September 2023

AbstractMost empirical research on biological shortfalls has focused on vertebrate taxa. This is important given many species in poorly studied groups such as invertebrates, plants, and fungi are predicted to possess high conservation risk. Here, we focus on Laboulbeniomycetes: a class of microfungi that are understudied. We examined four shortfalls: Linnean (knowledge gaps in species diversity), Wallacean (knowledge gaps in distributions), Latimerian (knowledge gaps in species persistence), and the newly introduced Scottian (knowledge gaps in species conservation assessments) shortfalls. The Linnean shortfall in Laboulbeniomycetes is hard to predict due to inconsistent species description rates. Analysis of distribution patterns indicates Laboulbeniomycetes are likely to experience an extremely high Wallacean shortfall, with many species having highly disjunct known distributions. Latimerian shortfall analysis shows over half (51%) of Laboulbeniomycetes have not been recorded in >50 years, while the group has a collective Scottian shortfall of 100%, given none of the 2454 described species have received an IUCN threat assessment. We suggest continued study of natural history collections, expanded citizen science programmes, and machine‐learning identification approaches as important tools for reducing knowledge shortfalls in both Laboulbeniomycetes and poorly studied taxa more generally.
Equivalent roles of marine subsidies and island characteristics in shaping island bird communities
Authors: Obrist Debora S. , Hanly Patrick J. , Kennedy Jeremiah C. , Fitzpatrick Owen T. , Wickham Sara B. , Nijland Wiebe , Reshitnyk Luba Y. , Darimont Chris T. , Starzomski Brian M. , Reynolds John D. 
Published: September 2023

AbstractAimSpecies distributions across islands are shaped by dispersal limitations, environmental filters and biotic interactions but the relative influence of each of these processes has rarely been assessed. Here, we examine the relative contributions of island characteristics, marine subsidies, species traits, and species interactions on avian community composition.LocationCentral Coast region of British Columbia, Canada.TaxonTerrestrial breeding birds.MethodsWe observed 3610 individuals of 32 bird species on 89 islands that spanned multiple orders of magnitude in area (0.0002–3 km2). We fit a spatially explicit joint species distribution model to estimate the relative contributions of island physical characteristics, island‐specific inputs of marine subsidies, species' traits, and biotic interactions on species distributions. Biogeographic characteristics included island area, isolation, and habitat heterogeneity, while marine influence was represented by forest‐edge soil δ15N, wrack biomass, shoreline substrate, and distance to shore. This approach also allowed us to estimate how much variation in distributions resulted from species' biological traits (i.e. body mass, feeding guild, feeding height, and nesting height).ResultsBird species distributions were determined almost equivalently by island biogeographic characteristics (23.5% of variation explained) and marine influence (24.8%). We detected variation in species‐specific responses to both island biogeographic characteristics and marine influence, but no significant effect of any biological trait examined. Additionally, we found evidence that habitat preferences were a more important driver than competitive interactions.Main ConclusionsAlthough most island biogeographic studies focus only on islands' physical characteristics, we found evidence for an equivalent role of marine subsidy in structuring island bird communities. Our study suggests that for small islands, disentangling the effects of island biogeographic characteristics, marine inputs, and biotic interactions is a useful next step in understanding species distributions.