bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of serum from laying hen and antiprolactin drug on egg production of indigenous chicken in Bangladesh
Authors: Parvez Misrat Masuma , Islam Rakibul , Rashid Bazlar , Hasan Mahmudul , Mobarak Hosne , Roy Kishor Kumar , Haque Md Anowarul 
Published: May 2023

The study was carried out to improve egg production by decreasing the inter sequence pause days in indigenous chicken through the use of antiprolactin agent (Bromocriptine) and serum from laying hen. Sixty indigenous (deshi) chickens of 20-22 weeks of age, were randomly assigned into four groups (A, B, C and D) and each group consisting of 15 hens. Group A designated as control, group B was treated with Bromocriptine orally at a dose of 640 μg/bird/day, group C was treated with serum of laying hen at a dose of 1 ml intramuscularly/bird/day and group D was treated with both serum and Bromocriptine at doses given to group B and C for the period of 15 March, 2015 to 16 June, 2015 and egg production, pause days, prolactin level, hematological parameter and egg qualities were observed. Egg production increased significantly (p<0.05) in all treated groups compared to the non- treated control group and the highest production was recorded in group D. Pause days and prolactin levels decreased significantly (p<0.05) in all treated groups and lowest were recorded in hens of group D. No significant (p>0.05) differences were observed in hematological values among the group of chicken. The present study reveals that combined treatment with Bromocriptine and serum from laying hen increases egg production without affecting the health of indigenous chickens.
Asian Australas. J. Biosci. Biotechnol. 2017, 2 (1), 51-54
PENGARUH MEDIA DESAIN GRAFIS BERBASIS ADOBE PHOTOSHOP TERHADAP KREATIVITAS BELAJAR SISWA
Authors: Musmuliadi Musmuliadi , Purmadi Ary 
Published: May 2023

Tujuan Penelitian ini adalah Untuk mengetahui Pengaruh Media Desain Grafis Berbasis Adobe Photoshop Terhadap Kreativitas Belajar Siswa Kelas X Pada Mata Pelajaran Desain Grafis Di SMK NW Kembang Kerang Kabupaten Lombok Timur Tahun Pelajaran 2016/2017. Metode Pengumpulan data yang digunakan dalam penelitian ini adalah angket sebagai metode pokok, observasi, wawancara dan dokumentasi sebagai metode pelengkap. Penelitian ini mengambil sampel siswa kelas X jurusan Multimedia di SMK NW Kembang kerang Kabupaten Lombok Timur. Analisis data dalam penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan analisis data statistic uji perbedaan rata-rata hitung dengan rumus t- test. Hasil analisis yang diperoleh dalam penelitin ini adalah t-hitung 4,434 dan t-tabel 2,103 dengan demikian t-hitung lebih besar dari t-tabel (4,434> 2,103) dengan taraf signifikansi 5%, ini berarti Hipotesis Nol (Ho) ditolak dan Hipotesis alternatif (Ha) diterima. Sehingga penelitian ini dapat dikatakan ada Pengaruh Media Desain Grafis Berbasis Adobe Photoshop Terhadap Kreativitas Belajar Siswa Kelas X Pada Mata Pelajaran Desain Grafis Di SMK NW Kembang Kerang Kabupaten Lombok Timur Tahun Pelajaran 2016/2017.Kata kunci: Media pembelajaran, Kreativitas Belajar
PENGARUH REINFORCEMENT GURU TERHADAP MOTIVASI BELAJAR SISWA PADA MATA PELAJARAN MATEMATIKA DI SMPN 2 SAKRA TIMUR
Authors: Sakti Hadi Gunawan 
Published: May 2023

Pendidikan di sekolah mempunyai tujuan untuk menjadikan para siswanya agar mencapai suatu perkembangan yang optimal sesuai dengan bakat, kemampuan, minat serta cita-citanya masing-masing. Untuk mencapai tujuan tersebut maka di dalam proses belajar mengajar seorang guru hendaknya menciptakan situasi lingkungan yang memungkinkan supaya anak aktif dalam belajar. Guru juga harus memiliki komponen dan kompetensi dalam interaksi belajar mengajar. Disamping memiliki komponen dan kompetensi yang dimiliki, seorang guru juga hendaknya memiliki keterampilan dalam memberikan reinforcement. Metode yang digunakan dalam penelitian ini bersifat kuantitatif, adapun jenis penelitian yangg eksperimen. Dan teknik dalam pengumpulan data penulis menggunakan angket dan metode dokumentasi. Dengan melihat dari jenis data, maka dapat ditentukan teknik analisis data. Dalam penelitian, karena data bersifat kuantitatif maka teknik analisis data yang digunakan adalah statistik dengan rumus korelasi.Untuk mengetahui ada atau tidak ada pengaruh pemberian reinforcement guru terhadap peningkatan motivasi belajar matematika pada siswa SMP Negeri 1 Sakra Timur, penulis mengolah data hasil penelitian menggunakan rumus korelasi r product moment. Dengan rumus korelasi didapat hasil rxy = 0,430, dengan memilih taraf signifikan 5%. Adapun taraf signifikan 5% didapat rt = 0,316. Hal ini menunjukkan bahwa r hitung lebih besar dari r tabel (rxy > rt) karena rxy > rt, maka hipotesis alternatif (Ha) diterima yaitu ada pengaruh reinforcement guru terhadap motivasi belajar siswa pada mata pelajaran matematika di SMP Negeri 2 Sakra Timur. Kata Kunci : Reinforcement
Impacts of gait biomechanics of patients with thoracolumbar kyphosis secondary to Scheuermann’s disease
Authors: Cheng Hao , Jiang Zi-Ang , Chen Liang , Wang Guo-Dong , Liu Xiao-Yang , Sun Jian-Min , Tsai Tsung-Yuan 
Published: May 2023

Introduction: Thoracolumbar kyphosis (TLK) is a common feature in patients with spinal deformities. However, due to limited studies, the impacts of TLK on gait have not been reported. The objective of the study was to quantify and evaluate the impacts of gait biomechanics of patients with TLK secondary to Scheuermann’s disease.Methods: Twenty cases of Scheuermann’s disease patients with TLK and twenty cases of asymptomatic participants were recruited into this study. And the gait motion analysis was conducted.Results: The stride length was shorter in the TLK group compared to control group (1.24 ± 0.11 m vs. 1.36 ± 0.21 m, p = 0.04). Compared to control group, the stride time and step time were more prolonged in the TLK group (1.18 ± 0.11s vs. 1.11 ± 0.08 s, p = 0.03; 0.59 ± 0.06 s vs. 0.56 ± 0.04 s, p = 0.04). The gait speed of the TLK group was significantly slower than it of control group (1.05 ± 0.12 m/s vs. 1.17 ± 0.14 m/s, p = 0.01); In the sagittal plane, the range of motion (ROM) of the hip in the TLK group was significantly smaller than that of the control group (37.71 ± 4.35° vs. 40.05 ± 3.71°, p = 0.00). In the transverse plane, the adduction/abduction ROMs of the knee and ankle, as well as the internal and external rotation of the knee, were smaller in TLK group than ROMs in the control group (4.66 ± 2.21° vs. 5.61 ± 1.82°, p = 0.00; 11.48 ± 3.97° vs. 13.16 ± 5.6°, p = 0.02; 9.00 ± 5.14° vs. 12.95 ± 5.78°, p = 0.00).Discussion: The main finding of this study was that measurements of gait patterns and joint movement of the TLK group were significantly lower than those of the control group. And these impacts have the potential to exacerbate degenerative progress of joints in the lower extremities. These abnormal features of gait can also serve as a guideline for physicians to focus on TLK in these patients.
The safety and efficacy of balloon-expandable versus self-expanding trans-catheter aortic valve replacement in high-risk patients with severe symptomatic aortic stenosis
Authors: Senguttuvan Nagendra Boopathy , Bhatt Hemal , Balakrishnan Vinod Kumar , Krishnamoorthy Parasuram , Goel Sunny , Reddy Pothireddy M. K. , Subramanian Vinodhini , Claessen Bimmer E. , Kumar Ashish , Majmundar Monil , Ro Richard , Lerakis Stamatios , Jayaraj Ramamoorthi , Kalra Ankur , Flather Marcus , Dangas George 
Published: May 2023

AimTransfemoral Trans-catheter Aortic Valve Replacement (TF-TAVR) is a safe and effective therapy compared with surgical aortic valve replacement (SAVR) in patients across all risk profiles using balloon-expandable valves (BEV) and self-expanding valves (SEV). Our aim was to compare safety and efficacy of BEV vs. SEV in high-risk patients undergoing TF-TAVR.Methods and resultsWe searched PubMed, EMBASE, Clinicaltrials.gov, Scopus, and Web of sciences for studies on patients with severe aortic stenosis undergoing TAVR. Primary outcome was 30-day all-cause mortality. Secondary outcomes defined by Valve Academic Research Consortium 2 (VARC-2) criteria were also examined. Six studies with 2,935 patients (1,439 to BEV and 1,496 to SEV) were included. BEV was associated with lower risk of all-cause mortality (2.2% vs. 4.5%; RR: 0.51; 95% CI: 0.31–0.82; p &lt; 0.006) and cardiovascular mortality [(2.5% vs. 4.3%; RR: 0.54; 95% CI: 0.32–0.90; p = 0.01) at 30 days compared with SEV. Implantation of more than one valve per procedure (0.78% vs. 5.11%; RR: 0.15; 95% CI: 0.07–0.31; p &lt; 0.00001), and moderate/severe AR/PVL (2.5% vs. 9.01%; RR: 0.3; 95% CI: 0.17–0.48); p &lt; 0.00001) were also lower in the BEV arm.ConclusionBEV TAVR is associated with reduced all-cause mortality (High level of GRADE evidence), cardiovascular mortality (very low level) at 30 days compared with SEV TAVR in high surgical risk patients. Data are necessary to determine if the difference in outcomes persists in longer-term and if the same effects are seen in lower-risk patients.
Systematic Review Registrationidentifier, CRD42020181190.
Subclinical postoperative atrial fibrillation: a randomized trial
Authors: Sabbag Avi , Berkovich Anat , Raanani Ehud , Volvovitch David , McIntyre William F. , Kassif Yigal , Kogan Alexander , Glikson Michael , Beinart Roy 
Published: May 2023

BackgroundPostoperative atrial fibrillation (POAF) is the most common complication of cardiac surgery, requiring interventions and prolonging hospital stay. POAF is associated with increased mortality and a higher rate of systemic thrombo-embolism. The rates of recurrent AF, optimal follow-up and management remain unclear. We aimed to evaluate the incidence of recurrent atrial fibrillation (AF) events, during long term follow-up in patients with POAF following cardiac surgery.MethodsPatients with POAF and a CHA2DS2-VASc score of ≥2 were randomized in a 2:1 ratio to either implantation of a loop recorder (ILR) or ECG monitoring using periodic Holters. Participants were followed prospectively for 2 years. The primary end point was the occurrence of AF longer than 5 min.ResultsThe final cohort comprised of 22 patients, of whom 14 received an ILR. Over a median follow up of 25.7 (IQR of 24.7–44.4) months, 8 patients developed AF, representing a cumulative annualized risk of AF recurrence of 35.7%. There was no difference between ILR (6 participants, 40%) and ECG/Holter (2 participants, 25% p = 0.917). All 8 patients with AF recurrence were treated with oral anticoagulation. There were no cases of mortality, stroke or major bleeding. Two patients underwent ILR explantation due to pain at the implantation site.ConclusionsThe rate of recurrent AF in patients with POAF after cardiac surgery and a CHA2DS2-VASc score of ≥2 is approximately 1 in 3 when followed systematically. Further research is need to assess the role of ILRs in this population.
Personal data governance and privacy in digital reproductive, maternal, newborn, and child health initiatives in Palestine and Jordan: a mapping exercise
Authors: Nemer Maysaa , Khader Yousef S. , Alyahya Mohammad S. , Pirlot de Corbion Alexandrine , Sahay Sundeep , Abu-Rmeileh Niveen M. E. 
Published: May 2023

IntroductionThere is a rapid increase in using digital technology for strengthening delivery of reproductive, maternal, newborn, and child health (RMNCH) services. Although digital health has potentially many benefits, utilizing it without taking into consideration the possible risks related to the security and privacy of patients' data, and consequently their rights, would yield negative consequences for potential beneficiaries. Mitigating these risks requires effective governance, especially in humanitarian and low-resourced settings. The issue of governing digital personal data in RMNCH services has to date been inadequately considered in the context of low-and-middle-income countries (LMICs). This paper aimed to understand the ecosystem of digital technology for RMNCH services in Palestine and Jordan, the levels of maturity of them, and the implementation challenges experienced, particularly concerning data governance and human rights.MethodsA mapping exercise was conducted to identify digital RMNCH initiatives in Palestine and Jordan and mapping relevant information from identified initiatives. Information was collected from several resources, including relevant available documents and personal communications with stakeholders.ResultsA total of 11 digital health initiatives in Palestine and 9 in Jordan were identified, including: 6 health information systems, 4 registries, 4 health surveillance systems, 3 websites, and 3 mobile-based applications. Most of these initiatives were fully developed and implemented. The initiatives collect patients' personal data, which are managed and controlled by the main owner of the initiative. Privacy policy was not available for many of the initiatives.DiscussionDigital health is becoming a part of the health system in Palestine and Jordan, and there is an increasing use of digital technology in the field of RMNCH services in both countries, particularly expanding in recent years. This increase, however, is not accompanied by clear regulatory policies especially when it comes to privacy and security of personal data, and how this data is governed. Digital RMNCH initiatives have the potential to promote effective and equitable access to services, but stronger regulatory mechanisms are required to ensure the effective realization of this potential in practice.
Gender differences in the impact of 3-year status changes of metabolic syndrome and its components on incident type 2 diabetes mellitus: a decade of follow-up in the Tehran Lipid and Glucose Study
Authors: Hadaegh Farzad , Abdi Amir , Kohansal Karim , Hadaegh Parto , Azizi Fereidoun , Tohidi Maryam 
Published: May 2023

BackgroundThe aim of this study was to examine the gender differences in the association between status changes of metabolic syndrome (MetS) and its components, using Joint Interim Statement (JIS) criteria, with the risk of type 2 diabetes mellitus (T2DM) among an urban population.MethodsThe study included 4,463 Iranian adult participants (2,549 women) aged ≥20 years. Based on status changes of MetS and its components during 3 years, subjects were categorized into four groups: MetS-free (reference), MetS-developed, MetS-recovery, and MetS-stable. A similar categorization was applied to MetS components. Multivariable Cox regression models were used for estimating hazard ratios (HRs) and women-to-men ratios of HRs (RHRs).ResultsDuring a median follow-up of 9.3 years, 625 T2DM events (351 women) occurred. Compared with the reference, the HRs of the MetS-developed, -recovery, and -stable groups among men for incident T2DM were 2.90, 2.60, and 4.92; the corresponding values for women were 2.73, 2.88, and 5.21, respectively (all p-values &lt; 0.01), without significant gender difference in these relationships. In both genders, the fasting plasma glucose (FPG) component, regardless of the change in status, was strongly and significantly associated with incident T2DM with HRs ranging from 2.49 to 9.42; a similar association was also found for high waist circumference (WC)-recovery and -stable groups, with HRs ranging from 1.58 to 2.85 (p-values ≤ 0.05). Regarding gender differences, the development and persistence of high blood pressure (BP) status exposed men to greater T2DM risk than women with women-to-men RHRs of 0.43 (0.26–0.72) and 0.58 (0.39–0.86), respectively. Moreover, stable low levels of high-density lipoprotein cholesterol (HDL-C) and high triglyceride (TG) levels conferred higher T2DM risk in women than in men, with women-to-men RHRs of 1.67 (0.98–2.86) and 1.44 (0.98–2.14), respectively (both p-values = 0.06).ConclusionAmong Tehranian adults, in both genders, all status changes of MetS, even those recovered from MetS, have a higher risk of T2DM compared to those who never had MetS. Also, all statuses of high FPG, in addition to recovered and stable high WC, were strongly associated with T2DM risk. Specifically, men with stable or developed high BP and women with stable dyslipidemic status were at differentially increased risk of incident T2DM.
Brown adipose tissue-derived exosomes delay fertility decline in aging mice
Authors: Zhang Hanke , Fang Yuqing , Gao Ying , Zeng Xinliu , Lu Zhenzhen , Liu Lin , Chen Chunyan , Huang Jiayu , Li Yanhui 
Published: May 2023

IntroductionOvarian aging has steadily grown to be a significant health issue for women as a result of the increase in average life expectancy and the postponement of reproductive age. One of the important pathological foundations of ovarian aging is formed by mitochondrial dysfunction, which causes decreases in follicle quantity and oocyte quality. In recent years, brown adipose tissue (BAT) transplantation has been proven as an effective treatment for aging-related diseases, such as ovarian aging. However, BAT transplantation is an invasive operation with long-term risks. Therefore, we need to find an alternative strategy.MethodsWe injected BAT-derived exosomes into eight-month-old C57BL/6 female mice. The fertility was detected by the estrous cycle and mating test. The changes of ovary and oocyte were measured by ovarian volume, organ coefficient, follicle counting, and oocyte maturation rate. ROS level, mitochondrial membrane potential and ATP level were measured to analyze the mitochondrial function of oocytes. The changes in metabolism were explored by cold stimulation test, body weight and blood sugar. The possible molecular mechanism was further investigated by RNA sequencing.ResultsIn terms of fertility, the estrous cycle of aging mice after BAT-derived exosome intervention was more regular, and the number of progenies and litters was increased. At the tissue level, the ovaries in the BAT-exosome group were larger, and the number of primordial follicles, secondary follicles, antral follicles and total follicles increased. At the cellular level, BAT-derived exosomes improved the maturation of oocytes in vivo and in vitro, increased the mitochondrial membrane potential and ATP levels of oocytes, and decreased ROS levels. Besides, BAT-derived exosomes ameliorated the metabolism and viability of aging mice. Furthermore, mRNA sequencing showed that BAT exosomes altered the expression levels of genes related to metabolism and the quality of oocytes.ConclusionBAT-derived exosomes enhanced mitochondrial function, promoted follicle survival, improved fertility, and extended ovarian lifespan in aging mice.
Identification of ferroptosis-related genes in the progress of NASH
Authors: He Linwei , Wang Jianming , Tao Baihua , Zhu Ruolan , Li Changbing , Ning Bo 
Published: May 2023

BackgroundNon-alcoholic steatohepatitis (NASH) is becoming more widespread, and some similarities exist between its etiology and ferroptosis. However, there are limited investigations on which ferroptosis-related genes (FRGs) are regulated in NASH and how to regulate them. We screened and validated the pivotal genes linked to ferroptosis in NASH to comprehend the function of ferroptosis in the development of NASH.MethodsTwo mRNA expression data were obtained from the Gene Expression Omnibus (GEO) as the training set and validation set respectively. FRGs were downloaded from FerrDb. The candidate genes were obtained from the intersection between differentially expressed genes (DEGs) and FRGs, and further analyzed using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). The hub genes were identified by the protein-protein interaction (PPI) network and Cytoscape. Then, FRGs closely related to the severity of NASH were identified and further confirmed using the validation set and mouse models. Ultimately, based on these genes, a diagnostic model was established to differentiate NASH from normal tissues using another data set from GEO.ResultsA total of 327 FRGs in NASH were acquired and subjected to GSEA. And 42 candidate genes were attained by overlapping the 585 FRGs with 2823 DEGs, and enrichment analysis revealed that these genes were primarily engaged in the fatty acid metabolic, inflammatory response, and oxidative stress. A total of 10 hub genes (PTGS2、IL1B、IL6、NQO1、ZFP36、SIRT1、ATF3、CDKN1A、EGR1、NOX4) were then screened by PPI network. The association between the expression of 10 hub genes and the progress of NASH was subsequently evaluated by a training set and verified by a validation set and mouse models. CDKN1A was up-regulated along with the development of NASH while SIRT1 was negatively correlated with the course of the disease. And the diagnostic model based on CDKN1A and SIRT1 successfully distinguished NASH from normal samples.ConclusionIn summary, our findings provide a new approach for the diagnosis, prognosis, and treatment of NASH based on FRGs, while advancing our understanding of ferroptosis in NASH.
Effect and degradation pathway of sulfamethoxazole removal in MBR by PVDF/DA modified membrane
Authors: Zhang Meilin , Li Shaofeng , Sun Jian , Sun Jianping , Wang Lei , Zhao Rui 
Published: May 2023

To reduce the hazard of sulfamethoxazole (SMX) to the water ecology, the removal mechanism of SMX in wastewater was revealed. This study evaluated the PVDF/DA modified membrane in the membrane bioreactor (MBR) toward the removal and degradation of SMX as a recalcitrant micropollutant. A strategy of dopamine for surface modification of polyvinylidene fluoride (PVDF) membrane was proposed, and PVDF/DA membrane was prepared. Subsequently, PVDF/DA was run in the MBR for 60 days, and the reactor could produce good removal ability for SMX after certain acclimation. When the SMX concentration increased from 0.5 to 2 mg/L, liquid chromatography was used for analysis, and the results showed that the average removal rate was above 85%. The removal effect of COD and NH4+-N and the degree of membrane fouling were also evaluated. By measuring the extracellular polymer (EPS) content, the results showed that after 30 days of operation, the protein and polysaccharide contents in the cake layer on the surface of the PVDF membrane were 1.35 times and 1.49 times that of PVDF/DA membrane, respectively, and the PVDF/DA membrane could alleviate membrane fouling, thereby improving the service life of the membrane and reducing its operating cost. Finally, degradation by-products are evaluated to achieve deeper insight into the degradation mechanisms in the MBR process.