bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conceptualizing multiplicity spectrum experiences: A systematic review and thematic synthesis
Authors: Eve Zarah , Heyes Kim , Parry Sarah 
Published: September 2023

AbstractBackgroundDissociative identity disorder and depersonalization–derealization have attracted research and clinical interest, facilitating greater understanding. However, little is known about the experience of multiplicity of self outside of traumagenic or illness constructs. Consequently, this systematic review explored how people identifying as having multiple selves conceptualize their experiences and identity.MethodsA comprehensive search of qualitative studies reporting lived experiences of multiplicity was conducted through PsycINFO, PubMed and Scopus (PROSPERO ID: CRD42021258555). Thirteen relevant studies were retrieved (N = 98, 16–64 years, conducted in the United Kingdom, the United States, Hungary and Poland).ResultsUsing line‐by‐line thematic synthesis, four analytical themes were developed: multiplicity: disorder versus experience; impact of understanding multiplicity; importance of supporting multiplicity; and continuum of experiences.DiscussionThis review highlights heterogeneity within multiplicity‐spectrum experiences, emphasizing the need for person‐centred, individualized understanding, separate from mental health conceptualizations. Therefore, training in person‐centred individualized care to promote self‐concept clarity is needed across health, education and social care. This systematic review is the first to synthesize voices of people with lived experience across the multiplicity spectrum, demonstrating how qualitative research can contribute to advancing our understanding of this complex phenomena with the community, acknowledging reciprocal psychosocial impacts of multiplicity and providing valuable recommendations for services.
Impact of climate change on the distribution and predicted habitat suitability of two fruit bats (Rousettus aegyptiacus and Epomophorus labiatus) in Ethiopia: Implications for conservation
Authors: Ahmed Ahmed Seid , Bekele Afework , Kasso Mohammed , Atickem Anagaw 
Published: September 2023

AbstractFruit bats serve as crucial bioindicators, seed dispersers, pollinators, and contributors to food security within ecosystems. However, their population and distribution were threatened by climate change and anthropogenic pressures. Understanding the impacts of these pressures through mapping distribution and habitat suitability is crucial for identifying high‐priority areas and implementing effective conservation and management plans. We predicted the distribution and extent of habitat suitability for Rousettus aegyptiacus and Epomophorus labiatus under climate change scenarios using average predictions from four different algorithms to produce an ensemble model. Seasonal precipitation, population index, land‐use land cover, vegetation, and the mean temperature of the driest quarter majorly contributed to the predicted habitat suitability for both species. The current predicted sizes of suitable habitats for R. aegyptiacus and E. labiatus were varied, on average 60,271.4 and 85,176.1 km2, respectively. The change in species range size for R. aegyptiacus showed gains in suitable areas of 24.4% and 22.8% in 2050 and 2070, respectively. However, for E. labiatus, suitable areas decreased by 0.95% and 2% in 2050 and 2070, respectively. The range size change of suitable areas between 2050 and 2070 for R. aegyptiacus and E. labiatus shows losses of 1.5% and 1.2%, respectively. The predicted maps indicate that the midlands and highlands of southern and eastern Ethiopia harbor highly suitable areas for both species. In contrast, the areas in the northern and central highlands are fragmented. The current model findings show that climate change and anthropogenic pressures have notable impacts on the geographic ranges of two species. Moreover, the predicted suitable habitats for both species are found both within and outside of their historical ranges, which has important implications for conservation efforts. Our ensemble predictions are vital for identifying high‐priority areas for fruit bat species conservation efforts and management to mitigate climate change and anthropogenic pressures.
Sap flux and stable isotopes of water show contrasting tree water uptake strategies in two co‐occurring tropical rainforest tree species
Authors: Sohel Md. Shawkat I. , Herbohn John L. , Zhao Ying , McDonnell Jeffrey J. 
Published: September 2023

AbstractThe short‐term dynamics of tree water use strategies for neighbouring co‐occurring species are poorly understood. Here, we quantify the high frequency changes in water sources and sap flux patterns of two commonly co‐occurring tropical rainforest tree species: Dendrocnide photinophylla (Kunth; Chew) and Argyrodendron peralatum (F.M. Bailey; Edlin ex J.H. Boas). A combination of continuous sap flux measurements and hourly sampling of xylem water stable isotope composition (δD and δ18O) were used to observe water use strategies during a 24‐h transpiration cycle. Sap flux ranged between 2.82 and 28.50 L day−1, with A. peralatum recording a 67% higher rate than D. photinophylla. For both tree species, sap flux increased with tree size and diurnal sap flux increase resulted in more isotopically enriched xylem water. A Bayesian Mixing Model analysis, which used sampled soil water isotopic composition from five soil depths ranging from of 0 to 1 m, revealed that D. photinophylla primarily used water from very shallow depth or soil surface layer (2–60 cm), while A. peralatum sourced its water mostly from deeper layers (60–100 cm). We propose that these differences in species' water consumption patterns are related to plant water storage capacity and wood anatomical features. This research demonstrates that combining xylem isotope composition and sap flux measurements can help reveal species‐specific water use strategies, which can be beneficial for improved process understanding in ecohydrological modelling.
Protonation Behavior of a Tetrahydrido Molybdenum(IV) Complex with Organic and Inorganic Acids
Authors: Queyriaux Nicolas , Durvin Nina , Leon Daniel , Boegli Marie‐Christine , Vendier Laure , Simonneau Antoine 
Published: September 2023

AbstractThe reaction of [MoH4(depe)2] (1) (depe=1,2‐bis(diethylphosphino)ethane) with different proton sources (HPtBu3+, C6H5COOH, C6F5COOH, H2SO4) was investigated. Whereas complete conversion of 1 into its protonated form is observed in the presence of the phosphonium salt, [MoH5(depe)2]+ only transiently forms upon treatment with the other acids. Further reactivity of the pentahydride complex is indeed noticed with the conjugated base, typically resulting in the formation of neutral (C6F5COOH, H2SO4) or cationic (PhCOOH) molybdenum dihydride complexes. The compounds were characterized by NMR spectroscopy and X‐ray crystallographic studies were performed when suitable crystals were obtained.
Isolation of a Dodecanuclear Polyoxo Cluster {Nb12O21} Showing a Rare Case of Five‐fold Coordinated Niobium(V) Centers with a Square Pyramidal Geometry
Authors: Andriotou Despoina , Henry Natacha , Duval Sylvain , Volkringer Christophe , Shepard William E. , Pourpoint Frédérique , Loiseau Thierry 
Published: September 2023

AbstractThe reactivity of the complexing anthracene‐9‐carboxylate ligand has been investigated with a niobium(IV) tetrachloride precursor (NbCl4 ⋅ 2THF) in isopropanol solvent. This resulted in the crystallization of a molecular assembly containing two distinct {Nb12O21} cores surrounded by multiple isopropanolate and anthracenoate ligands. The compound is formulated [Nb12((μ3‐O)3(μ‐O)18(C15H9O2)8(OiPr)10] ⋅ [Nb12(μ3‐O)2(μ‐O)19(C15H9O2)8(OiPr)10] illustrating the two different dodecameric oxo‐clusters, for which the niobium(IV) precursor was oxidized in the niobium(V) state during the reactional process. The two distinct {Nb12O21} units mainly differs by the environment of the niobium centers, which exhibits unexpected five‐fold coordination (square pyramid) for some of them, together with the classical six‐fold coordination (octahedron) as usually found for niobium(V). In the crystallization process, the. IR spectroscopy was used to analyze the esterification reaction occurring between the anthracene acid an isopropanolate ligands responsible of the production of water used in the oxo‐condensation of the niobium centers. 93Nb Solid state NMR was tentatively used to assess the occurrence of the different niobium environments.
Diastereoselective Dearomatization of Chalcone‐Based Quinolinium Salts to Assemble Bridged Quinobenzazepine Polycycles
Authors: Luo Chengxiang , Li Chaoyang , Zhang Lijie , Liu Xiongli , Cheng Pengfei , Wang Qilin 
Published: September 2023

AbstractQuinobenzazepines are useful in medicinal chemistry, but their synthesis is very challenging. Herein, we designed and synthesized a range of multi‐functional chalcone‐based quinolinium salts; their synthetic application in the rapid and straightforward construction of quinobenzazepines was successfully explored. A wide range of oxa‐bridged quinobenzazepine polycycles were afforded serendipitously through a dearomative cascade reaction of our newly developed quinolinium salts and acetylacetone. This synthetic strategy features high bond‐ and ring‐forming efficiency and complete regio‐ and diastereoselective control.
Academic performance of engineering students: A predictive validity study of first‐year GPA and final‐year CGPA
Authors: Nurudeen Abdulhakeem Hassan , Fakhrou Abdulnaser , Lawal Nuruddeen , Ghareeb Sara 
Published: September 2023

AbstractStudents' academic achievement is regarded as the scholastic standing of students at the end of a given study period that is expressed in terms of grades. This study focused on students' first‐year GPA as a predictor of final‐year CGPA and the relationship between demographic attributes of the students to academic achievement. An ex‐post factor research approach was adopted, and Pearson's correlation and Regression Analysis were fitted with the data using Minitab software. The results of the study highlighted that first‐year GPA had a strong positive relationship with final‐year CGPA which is an indication that first‐year GPA greatly influences final‐year CGPA meanwhile, demographic characteristics have no significant correlation with students' final‐year CGPA. Finally, the correlations drawn from this study indicated that first‐year GPA had a strong positive relationship with final‐year CGPA. Therefore, the students should be properly guided, University administrators, Faculty members, policy‐makers and other stakeholders should effectively develop a monitoring blueprint for students' academic progress as poor performance has severe consequences on students, teachers should inculcate effective learning culture among students, while government and its supervisory agencies should provide adequate teaching and learning resources, create enabling learning environment for effective service delivery that focuses on improving students' performance in Engineering.
From Consensus Standards to Evidence of Claims: Assessment and Accreditation in the Case of Teacher Education
Authors: Murray Frank Brush 
Published: September 2023

AbstractTo what extent should accreditation focus on the processes of assessing student learning outcomes, and to what extent should it primarily be concerned with the levels of student attainment within the institution or program under review? There is a need to evaluate the purposes of procedural and substantive standards and the claims they make about graduates' competence.
qRT‐PCR analysis of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN in colon cancer lymph nodes—An improved method for assessment of tumor stage and prognosis
Authors: Lindmark Gudrun , Olsson Lina , Sitohy Basel , Israelsson Anne , Blomqvist Joel , Kero Sara , Roshdy Tamer , Söderholm Mattias , Turi Annamaria , Isaksson Jessica , Sakari Thorbjörn , Dooper Michiel , Dafnis George , Forsberg Pehr , Skovsted Susanne , Walldén Maria , Kung Chih‐Han , Rutegård Martin , Nordmyr Johanna , Muhrbeck Måns , Hammarström Sten , Hammarström Marie‐Louise 
Published: September 2023

AbstractOne fourth of colorectal cancer patients having curative surgery will relapse of which the majority will die. Lymph node (LN) metastasis is the single most important prognostic factor and a key factor when deciding on postoperative treatment. Presently, LN metastases are identified by histopathological examination, a subjective method analyzing only a small LN volume and giving no information on tumor aggressiveness. To better identify patients at risk of relapse we constructed a qRT‐PCR test, ColoNode, that determines levels of CEACAM5, KLK6, SLC35D3, MUC2 and POSTN mRNAs. Combined these biomarkers estimate the tumor cell load and aggressiveness allocating patients to risk categories with low (0, −1), medium (1), high (2) and very high (3) risk of recurrence. Here we present result of a prospective, national multicenter study including 196 colon cancer patients from 8 hospitals. On average, 21 LNs/patient, totally 4698 LNs, were examined by both histopathology and ColoNode. At 3‐year follow‐up, 36 patients had died from colon cancer or lived with recurrence. ColoNode identified all patients that were identified by histopathology and in addition 9 patients who were undetected by histopathology. Thus, 25% of the patients who recurred were identified by ColoNode only. Multivariate Cox regression analysis proved ColoNode (1, 2, 3 vs 0, −1) as a highly significant risk factor with HR 4.24 [95% confidence interval, 1.42‐12.69, P = .01], while pTN‐stage (III vs I/II) lost its univariate significance. In conclusion, ColoNode surpassed histopathology by identifying a significantly larger number of patients with future relapse and will be a valuable tool for decisions on postoperative treatment.
Application of a skin and liver Chip2 microphysiological model to investigate the route‐dependent toxicokinetics and toxicodynamics of consumer‐relevant doses of genistein
Authors: Tao Thi‐Phuong , Brandmair Katrin , Gerlach Silke , Przibilla Julia , Schepky Andreas , Marx Uwe , Hewitt Nicola J. , Maschmeyer Ilka , Kühnl Jochen 
Published: September 2023

AbstractThe HUMMIC skin–liver Chip2 microphysiological system using EpiDerm™ and HepaRG and stellate liver spheroids was used to evaluate the route‐specific metabolism and toxicodynamic effects of genistein. Human‐relevant exposure levels were compared: 60 nM representing the plasma concentration expected after topical application of a cosmetic product and 1 μM representing measured plasma concentrations after ingesting soya products. Genistein was applied as single and repeated topical and/or systemic doses. The kinetics of genistein and its metabolites were measured over 5 days. Toxicodynamic effects were measured using transcriptional analyses of skin and liver organoids harvested on Days 2 and 5. Route‐specific differences in genistein's bioavailability were observed, with first‐pass metabolism (sulfation) occurring in the skin after topical application. Only repeated application of 1 μM, resembling daily oral intake of soya products, induced statistically significant changes in gene expression in liver organoids only. This was concomitant with a much higher systemic concentration of genistein which was not reached in any other dosing scenario. This suggests that single or low doses of genistein are rapidly metabolised which limits its toxicodynamic effects on the liver and skin. Therefore, by facilitating longer and/or repeated applications, the Chip2 can support safety assessments by linking relevant gene modulation with systemically available parent or metabolite(s). The rate of metabolism was in accordance with the short half‐life observed in in vivo in humans, thus supporting the relevance of the findings. In conclusion, the skin–liver Chip2 provides route‐specific information on metabolic fate and toxicodynamics that may be relevant to safety assessment.
Trace detection of canine distemper virus based on Michelson‐interferometer sensing probe
Authors: Zhang Xinyu , Hou Xiangyu , Feng Wenlin 
Published: September 2023

AbstractA single‐mode‐fiber (SMF)‐multimode‐fiber (MMF)‐tri‐core‐fiber (TCF) Michelson probe structure is proposed for trace detection of canine distemper virus (CDV). One end of the TCF is cut flat and fused with the multimode fiber, and the other end is coated with a silver film to enhance the reflection, and an optic‐fiber sensing probe with SMF‐MMF‐TCF structure is obtained. The (PDDA/PSS)3 multilayer film is modified on the surface of the fiber by layer‐by‐layer self‐assembly method as a polyelectrolyte binder to immobilize CDV antibodies to form a (PDDA/PSS)3/CDV antibody composite membrane for specific detection of CDV antigens. The response‐recovery test of the sensor is performed to verify its repeatability. The detection limit, the sensitivity, and the linear fitting degree for CDV antigen are 0.1236 pg/mL, 1.1776 dB/(pg/mL), and 0.9899, respectively. At the same time, the stability, selectivity, and clinical samples of the sensors were also verified.
N‐acetyl‐l‐tryptophan (NAT) ameliorates radiation‐induced cell death in murine macrophages J774A.1 via regulating redox homeostasis and mitochondrial dysfunction
Authors: Singh Darshana , Malhotra Poonam , Agarwal Prerna , Kumar Raj 
Published: September 2023

AbstractIonizing radiation interacts with the immune system and induces molecular damage in the cellular milieu by generating reactive oxygen species (ROS) leading to cell death. The present study was performed to investigate the protective efficacy of N‐acetyl‐L‐tryptophan (NAT) against gamma‐radiation‐induced cell death in murine macrophage J774A.1 cells. The radioprotective efficacy of NAT was evaluated in terms of cell survivability, effect on antioxidant enzyme activity, and free radicals inhibition. Radioprotective efficacy of NAT pretreatment to irradiated cells was assessed via cell cycle progression, mitochondrial membrane potential (MMP) perturbation, and apoptosis regulation using flow cytometry. Results of the study demonstrated significant radioprotective efficacy (>80%) of NAT in irradiated cells as estimated by sulforhodamine B (SRB), MTT, and clonogenic assay. Significant (p < 0.001) reduction in ROS, xanthine oxidase, and mitochondrial superoxide levels along with increment in catalase, glutathione‐s‐transferase, glutathione, and ATPase activities in NAT pretreated plus irradiated cells was observed as compared to the gamma‐irradiated cells. Further, significant (p < 0.001) stabilization of MMP and reduction in apoptosis was also observed in NAT pretreated plus irradiated cells as compared to irradiated cells that not pretreated with NAT. The current study demonstrates that NAT pretreatment to irradiated cells protects against gamma radiation‐induced cell death by reducing oxidative stress, stabilizing MMP, and inhibiting apoptosis. These observations conclusively highlight the potential of developing NAT as a prospective radioprotective agent upon further validation using in‐depth preclinical assessment in cellular and animal models.
The upregulation of miR‐3945 in CD14+ monocytes is the risk factor for cardiovascular disease
Authors: Xu Wei , Liu Tingting , Liu Xin 
Published: September 2023

AbstractPatients with type 1 diabetes (T1DM) show an increased risk of cardiovascular disease. Bioinformatics analysis revealed that it is characterized by changes in the function of CD14+ mononuclear macrophages. The current study was to explore the potential relationship between the miR‐3845/TRIM35/PKM2 and abnormal polarization of mononuclear macrophages. Using bioinformatics to analyze the gene expression of mononuclear macrophages. The polarization of macrophages was analyzed using flow cytometry, and the expression changes of TRIM35/PKM2 were analyzed using Western blot, luciferase activity assay, and co‐immunoprecipitation. Database analysis showed that T1DM patients showed an abnormal increase of miR‐3945 in CD14+ monocyte macrophages. miR‐3945 targets TRIM35 to release PKM2 to cytometry, and PKM2 causes M1‐like polarization of mononuclear macrophages. Database analysis showed that miR‐3945 was abnormally upregulated in CD14+ monocytes in T1DM patients. miR‐3945 upregulates the expression of PKM2 in the cytoplasm by targeting TRIM35, which leads to M1 polarization of macrophages.
Clinician perspectives on technology‐enhanced in vivo exposures during prolonged exposure therapy for PTSD
Authors: Brown Delisa G. , Jarnecke Amber M. , Saraiya Tanya C. , Santa‐Ana Elizabeth , Acierno Ron , Reese Mclain , Adams Robert , Harley William , Back Sudie E. 
Published: September 2023

AbstractObjectiveTo investigate clinicians' perceptions regarding the use of mobile technology tools during prolonged exposure (PE) therapy to allow for monitoring and enhancing in‐vivo exposures (IVEs).MethodsClinicians with training in PE therapy (N = 32; average of 9 years of practice) completed surveys asking about their perspectives on the utility of virtually attending IVEs with patients while simultaneously having access to real‐time subjective and physiological data (i.e., heart rate, galvanic skin conductance) to guide exposure exercises and assure optimal stimulus engagement.ResultsFindings showed clinicians to have a favorable view of applying technology devices and systems to enhance IVEs of PE therapy. Most clinicians (93.8%) believed that real‐time monitoring of IVEs—particularly monitoring patients' subjective distress and completion of and duration of time in the IVE—would be useful and significantly enhance PE therapy.ConclusionThe positive perceptions toward integrating technology into IVEs in this study have important implications for the development and implementation of technology‐enhanced PE therapy. A mobile technology system that incorporates real‐time indicators of engagement (i.e., both subjective and physiological) during IVEs and allows clinicians to review recordings of, or virtually accompany, patients during IVEs has the potential to innovate and transform PE and other exposure‐based treatments. Clinicians also believed that technology‐enhanced IVEs may help reduce early termination from PE.
Pig slurry organic matter transformation and methanogenesis at ambient storage temperatures
Authors: Dalby Frederik Rask , Ambrose Herald Wilson , Poulsen Jan Struckmann , Nielsen Jeppe Lund , Adamsen Anders Peter S. 
Published: September 2023

AbstractManure management is a significant source of global methane emissions, and there is an increased interest in understanding and predicting emissions. The hydrolysis rate of manure organic matter is critical for understanding and predicting methane emissions. We estimated hydrolysis rate constants of crude protein, fibers, and lipids and used the Arrhenius equation to describe its dependency on temperature. Simultaneously, measurements of methane emission, 13/12C isotope ratios, and methanogen community were conducted. This was achieved by incubating fresh pig manure without inoculum at 10°C, 15°C, 20°C, and 25°C for 85 days in a lab‐scale setup. Hydrolysis of hemicellulose and cellulose increased more with temperature than crude protein, but still, hydrolysis rate of crude protein was highest at all temperatures. Results suggested that crude protein consisted of multiple substrate groups displaying large differences in degradability. Lipids and lignin were not hydrolyzed during incubations. Cumulative methane emissions were 7.13 ± 2.69, 24.6 ± 8.00, 66.7 ± 4.8, and 105.7 ± 7.14 gCH4 kgVS−1 at 10°C, 15°C, 20°C, and 25°C, respectively, and methanogenic community shifted from Methanosphaera toward Methanocorpusculum over time and more quickly at higher temperatures. This study provides important parameter estimates and dependencies on temperature, which is important in mechanistic methane emission models. Further work should focus on characterizing quickly degradable substrate pools in the manure organic matter as they might be the main carbon source of methane emission from manure management.