bluuebunny/crossref_metadata_2025_split huggingface dataset:
An experience with simultaneous integrated boost-volumetric-modulated arc therapy in the definitive treatment of head and neck cancer: An Indian data
Authors: Shivananjappa Rashmi , Mandal Sanjeet Kumar , Vishwanathan Bhaskar , Geeta S N 
Published: June 2023

ABSTRACT

Background:
There are very few prospective studies comparing simultaneous integrated boost versus sequential boost in the setting of definitive treatment modality of head and neck squamous cell cancer (HNSCC), especially in the Indian scenario.

Materials and Methods:
We prospectively randomized 50 patients with biopsy-proven squamous cell carcinoma of the oropharynx, hypopharynx, and larynx malignancies, stage T1–3, enlarged node measuring ≤3 cm that are planned for definitive radiotherapy with chemotherapy into either hypo-fractionated simultaneous integrated (Hypo-SIB VMAT) boost arm or conventional (Conv-VMAT) boost arm.

Results:
Most of the patients were men and aged less than 50 years. Patients with nodal involvement were 76% in Hypo-SIB VMAT and 80% in Conv-VMAT arm. The overall stage group distribution of II, III, and IVA were 16%, 44%, 40%, and 12%, 56%, and 32%, respectively, in both arms. All patients completed the intended treatment in both arms. Overall survival at the end of 2 years was 84% in Hypo-SIB VMAT arm and 80% in the Conv-VMAT arm (P = 0.25); disease-free survival (DFS) was 88% and 72%, respectively (P = 0.12); and locoregional recurrence-free survival (LRFS) was 92% and 84%, respectively (P = 0.38). All the acute and chronic toxicities in both the arms were comparable with no significant difference in any of the toxicities. The average overall treatment time (OTT) in Hypo-SIB VMAT arm is 39.4 days and in Conv-VMAT arm is 50.2 days (P = 0.00001) which is statistically significant.

Conclusions:
Accelerated Hypo-SIB VMAT has similar response and toxicities as compared to Conv-VMAT in the setting of definitive concurrent chemoradiation of HNSCC patients with the advantage of less OTT, faster treatment delivery, and patient compliance.
Expression of TP53 in oral squamous cell carcinoma and its correlation with adverse histopathological features
Authors: Giri Ranjana , Hota Subhransu Kumar , Sahu Subrat Kumar , Senapati Urmila 
Published: June 2023

ABSTRACT

Background:
This study aimed to evaluate the expression of TP53 in oral squamous cell carcinoma (OSCC) and to correlate its expressions with adverse histopathological features like depth of invasion (DOI), lymphovascular invasion (LVI), perineural invasion (PNI), extranodal extension (ENE), and margin status which significantly affect the prognosis.

Methodology:
This cross-sectional study included 48 patients of OSCC who underwent surgical resection. All the histopathological adverse features such as DOI, LVI, PNI, ENE, margin status were noted. Immunohistochemical expression of TP53 was noted and a correlation of TP53 with histopathological adverse features was done. Statistical analysis was performed using SPSS software.

Results:
TP53 immunopositivity was seen in 45.83% (22/48) of cases. TP53 has a statistically significant correlation with margin status (P = 0.002). Similarly, TP53 expression is more in cases with LVI (100% cases) though the value is not statistically significant. TP53 expressions are more in positive margin cases and less if the margin is >5 mm. Similarly, TP53 expression is more in cases with LVI (100% cases) though the value is not statistically significant.

Conclusion:
Few parameters that did not show the correlation of TP53 with adverse histopathological features could be attributed to a small sample size. Further studies with a large number of cases and using other ancillary molecular diagnostic techniques would throw further light on the exact alteration of TP53 in our population and their association with histopathological prognostic features.
Frequency and pattern of chromosomal abnormalities in acute myeloid leukemia from Western India: A retrospective study
Authors: Vundinti Babu Rao , Korgaonkar Seema , Dhangar Somprakash , Jijina Farah , Shanmukhaiah Chandrakala 
Published: June 2023

ABSTRACT

Context:
Chromosomal abnormalities play an important role in diagnosis and prognosis of hematological diseases.

Aims:
The aim of the present study was to study the pattern and frequency of chromosomal aberrations in acute myeloid leukemia (AML) subgroups from western India.

Settings and Design:
A retrospective study was conducted through evaluating laboratory proforma which were filled during 2005 to 2014 for diagnosis and treatment of AML subjects.

Methods and Material:
We have studied chromosomal aberrations in 282 subjects with AML from western India. AML patients were sub-grouped according to FAB classification. Cytogenetic study using conventional cytogenetics (GTG-banding) and Fluorescence in situ hybridization (FISH) was carried out using FISH probes (AML1/ETO, PML/RARA, CBFB).

Statistical analysis:
Student’s t test for continuous variables and Pearson’s Chi-squared test for categorical variables were used to identify the relationship between variables.

Results:
Cytomorphological study revealed AML- M3 as most frequent (32.3%) group followed by AML-M2 (25.2%) and AML-M4 (19.9%). Chromosomal abnormalities were identified in 145 (51.42%) of the total AML cases. A high frequency (38.6%) of chromosomal abnormalities was identified in AML-M3 subgroup as compared to AML-M2 (31%) and AML-M4 (20.6%).

Conclusions:
Cytogenetic study is important for the diagnosis and management of the AML patients. Our study identified chromosomal abnormalities in AML subgroups with varied frequencies. It is important in diagnosis and monitoring of the disease. As younger AML patients were more affected in our study, etiological factors such as environmental factors need to be studied. Combination of conventional cytogenetics and FISH has an advantage of identifying high frequency of chromosomal aberrations in AML patients.
Prevalence of Keratoconus and Keratoconus Suspect among Patients Seeking Refractive Surgery in Syria
Authors: Salman Abdelrahman , Darwish Taym , Badla Abdul Aziz , Askar Mohammad , Al-Rufayie Moussa , Ghabra Marwan , Haddeh Yusra , Kailani Obeda , Shaaban Rafea , Hajjo Samer , Hasan Hiba , Ali Ali 
Published: June 2023

Abstract:

PURPOSE:
The purpose of this study was to determine the prevalence of keratoconus (KC) and keratoconus suspect (KCS) among patients seeking refractive surgery in Syria.

METHODS:
This is a retrospective multicenter screening study. The study was conducted in Damascus University, Tishreen University, and Tartous Specialist Eye Center (a private center). Data were collected from refractive surgery candidates referred for preoperative evaluation before laser in situ keratomileusis, photorefractive keratectomy, intrastromal corneal rings, and phakic intraocular lens implantation. Corneal parameters were obtained by Scheimpflug–Placido tomography, Sirius (CSO, Italy).

RESULTS:
A total of 1479 patients were included in this analysis. The prevalence rates of KC and KCS were 18.19% (269/1479) and 13.52% (200/1479), respectively. In addition, patients with KC were found to have higher percentages of eye rubbing and astigmatism than suspect and normal (P < 0.0001).

CONCLUSION:
High prevalence rate of KC was found among patients seeking refractive surgery in Syria. Although this study was carried out on a highly selective population, it may reflect a high prevalence rate in a general population in Syria.
An evaluation of clinical outcome of total alloplastic temporomandibular joint replacement and costochondral graft in temporomandibular joint ankylosis cases – A retrospective study
Authors: Mishra Abhishek , Roy Choudhury S. K. , Bhandari S. K. , Pandey Satyanarayan 
Published: June 2023

Background:
The temporomandibular joint (TMJ) ankylosis management incorporates various modalities. Total alloplastic temporomandibular joint replacement (TJR) has opened a new avenue in TMJ reconstruction. Costochondral grafts (CCGs) are the gold standard treatment option.

Aim:
This study was designed to compare the clinical outcome between total alloplastic TJR and CCG in TMJ ankylosis cases.

Materials and Methods:
The retrospective data of patients were collected between 2017 and 2020. A total of 12 TJR cases and 8 cases of CCG were included in the study. Maximum mouth opening was recorded in mm and pain score/diet score was recorded on a Visual Analog Score system where 0 was no pain/normal diet and 10 was worse pain/liquid diet. The data were statistically analyzed using the “two-sample t-test (Welch's t-test).”

Results:
The mean interincisal opening in the TJR group was 32.67 (±2.19) and in the CCG group was 33.71 (±4.77). The pain reduction score was better in the TJR group with 0.5 (±0.90) and the diet score was better in the CCG group with 0.714 (±0.95).

Conclusion:
The stock TJR devices have a predictable outcome with a good pain reduction score and an acceptable diet score; however, the autogenous CCG is still better in terms of maximum mouth opening. Although failed CCG cases can be taken up for further correction with the TJR.
Atraumatic myositis ossificans of mentalis muscle
Authors: Govindaraju Roopashri , Ali Sheema H. , Baig Muqeet , Shetty Siri C. N. , Reddy Soundarya Narayana , Jain Vijay 
Published: June 2023

Rationale:
Atraumatic myositis ossificans circumscripta is a benign condition characterized by the aberrant formation of bone in extraskeletal soft tissues without a usual connection to trauma.

Patient Concern:
A female patient of around 17 years of age reported with the main complaint of pain and swelling over the chin area for 6 months with no history of trauma.

Diagnosis:
Clinical, radiographic, and histopathological examinations were performed and all signs and symptoms pointed to a diagnosis of Atraumatic Myositis Ossificans in the Mentalis muscle.

Intervention:
Surgical exploration of the area concerned was done under (L.A) local anesthesia with adrenaline (1:1,00,000), where the nodes were extracted from the lower surface of the Mentalis muscle. The wound was sutured back to its normal physiologic anatomy, and the patient then was advised of postoperative instructions.

Results:
The patient recovered with a good prognosis and returned to a normal routine with good functional capacity.

Lessons Learned:
The practitioner must consider Atraumatic Myositis ossificans as a viable diagnosis for painful soft tissue calcification when a history of trauma is not present.
Pengaruh Store Atmosphere, Product Assortment dan Harga Terhadap Minat Beli Pada Lottemart Center Point Medan
Authors: Simanjuntak Demak Claudia Yosephine , Samosir Edward Nasareth , Simamora Teresia Indah Sari 
Published: June 2023

Lotte Mart Center Point Medan is a company engaged in trading services with a wholesale sales system. Lottemart Center Point Medan strives to continue to increase consumer buying interest. The purpose of research is to find out partially and simultaneously the influence of store atmosphere, product variety, and the price of consumer buying interest at Lotte Mart Center Point Medan. The research method used is descriptive quantitative. The independent variables of this research are store atmosphere, product variety, and price. The dependent variable of the study is buying interest. The population technique in this study uses an unlimited population because the population in this study is not possible to be calculated as a whole, so the population is all consumers who visit Lotte Mart Center Point Medan. The sampling method in this study was purposive sampling with a total of 90 people. Data collection techniques were carried out by observation, interviews, and questionnaires. The data were then analyzed using the F test and t test. The results of the study found that store atmosphere, product variety, and prices at Lotte Mart Center Point Medan had an effect on buying interest simultaneously and partially. The magnitude of the influence of store atmosphere, product variety, and price on buying interest at Lotte Mart Center Point Medan is 88.4%, while 11.6% is influenced by variables other than careful variables.
EFEKTIVITAS BIOFUNGISIDA Trichoderma koningii TERHADAP PENCEGAHAN PENYAKIT JAMUR AKAR PUTIH DI PEMBIBITAN BATANG BAWAH TANAMAN KARET (Hevea brasiliensis)
Authors: Tarigan Gema , Mardiana Wahyuni  , Guntoro  
Published: June 2023

One of the main obstacles in rubber cultivation is the white root fungus (JAP) attack which caused by Rigidophorus ligonosus. This pathogen infects rubber plants from the nursery until the mature plants. Efforts to control the disease have been carried out by chemical, technical culture and use of biological agencies. This research was conducted at the STIP-AP Medan in January 2017 to June 2017, this study used a non-factorial Randomized Block Design (RBD) with four replications and four treatments. Using Trichoderma koningii with somes doses were 20 grams, 30 grams, and 40 grams/seedling. The results of this study indicate that the biofungicide application of Trichoderma koningii 30 g/seedling produces the greatest inhibition of the rubber plants seedling nursery against the growth of pathogens Rigidoporus lignosus.
Salary Prediction Model for Non-academic Staff Using Polynomial Regression Technique
Authors: Ayua Samuel Iorhemen , Malgwi Yusuf Musa , Afrifa James 
Published: June 2023

The idea of regression has increased rapidly and significantly in the machine learning domain. This paper builds a salary prediction model to predict a justifiable salary of an employee commensurate to the increase or decrease in exchange rate (XR) using polynomial regression (PR) techniques of degree 2 in Jupyter Notebook on Anaconda Navigator tool. Predicting a feasible salary for an employee by the employer is a challenging task since every employee has a high goal and hope as the standard of leaving increases without a corresponding increase in salary. This model uses a salary dataset from Taraba State University, Jalingo, Nigeria in building and training the model and XR dataset for the prediction of employee salary. The result of the research shows that since the distribution of the dataset was nonlinear and the major feature significant in determining employee’s salary from the in-salary dataset was grade level and XR, this fully confirmed the use of PR algorithm. The research has immensely contributed to the knowledge and understanding of regression techniques. The researcher recommended other machine learning algorithms explored with various salary datasets and the potential applicability of machine learning fully incorporated in the financial department on the large dataset for better performance. The model performance was evaluated using R2 scores accuracy and the value of 97.2% realized, indicating how well the data points fit the line of regression and unseen dataset in the developed model.

Received: 24 February 2023 | Revised: 10 May 2023 | Accepted: 26 May 2023

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The average XR data that support the findings of this study are openly available at www.cbn.gov.ng/rates/exrate.asp.

Author Contribution Statement
Samuel Iorhemen Ayua: Conceptualization, Methodology, Software, Formal analysis, Data curation, Visualization, Project administration. Yusuf Musa Malgwi: Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Supervision, Project administration. James Afrifa: Validation, Resources, Visualization.
DETERMINATION OF HEMOGLOBIN A1c, LIPID PROFILES, HOMOCYSTEINE, OXIDATIVE STRESS AND PHYSICAL ACTIVITY LEVELS IN DIABETIC AND/OR NON-DIABETIC COVID-19 PATIENTS
Authors: ÖZDEMİR Kadirhan , SARUHAN Ercan , KAYA Gözde , KAYA BENLİ Tuba , MERAL Orhan , BOZOĞLAN Hümeyra , DEMİR Halit , DEMİR Canan , KAVAK Servet 
Published: June 2023

Objective: The coronavirus disease 2019 (Covid-19) pandemic results in higher morbidity and mortality rates. This study aims to compare hemoglobin A1c (HbA1c), lipid profiles, homocysteine, oxidative stress, and physical activity levels between diabetic Covid-19 patients (group I), non-diabetic Covid-19 patients (group II), and healthy controls (group III).
Method: HbA1c, lipid profiles, homocysteine, oxidative stress, oxidant, and antioxidant status were analyzed from the venous blood samples and physical activity levels were measured with International Physical Activity Questionnaire. All the parameters were compared between the groups (n=16 for each group).
Results: HbA1c and fasting blood glucose levels in group I were higher than group II and III (p
Implementasi Ta’zir Pada Pembiayaan Ijarah Al Muntahiya Bit Tamlik (IMBT) Di Bank Danamon Syariah Kantor Cabang Gunung Agung Denpasar
Authors: Kusjuniati Kusjuniati , Jekti Dyah Soelistya 
Published: June 2023

Pembiayaan dengan akad Ijarah Al Muntahiya Bit Tamlik tentunya tidak terlepas dari risiko-risiko yang akan timbul yakni pembiayaan bermasalah atau penundaan pembayaran yang dapat mengakibatkan kerugian bagi pihak bank. Agar Bank tidak mengalami kerugian secara terus menerus dan nasabah membayar angsuran sesuai dengan kesepakatan disaat awal akad pihak bank melakukan berbagai strategi dan kebijakan untuk menghindari adanya wanprestasi dari para nasabah. Nasabah yang melakukan wanprestasi seperti menunda-nunda angsuran pembiayaan yang sebenarnya mampu untuk membayarnya maka akan dikenakan sanksi sesuai dengan fatwa DSN-MUI No.17 Tahun 2000 yaitu dengan sanksi Ta’zir. Bank Danamon Syariah Cabang Denpasar telah mengimplementasikan Ta’zir tersebut terhadap nasabahnya yang melakukan penundaan pembayaran angsuran terutama pada pembiayaan Ijarah Muntahiyah Bit Tamlik. Pembiayaan Ijarah Al Muntahiya Bit Tamlik pada bank tersebut merupakan pembiayaan sewa yang diakhiri dengan pemindahan kepemilikan barang atau sejenis perpaduan antara kontrak jual beli dan sewa atau lebih tepatnya akad sewa yang diakhiri dengan kepemilikan barang.
Effect of Lawsuits on Professional Well-Being and Medical Error Rates Among Orthopaedic Surgeons
Authors: Adelani Muyibat A. , Hong Zachery , Miller Anna N. 
Published: June 2023

Introduction:
Orthopaedic surgery is one of the most cited specialties among legal claims. Malpractice lawsuits are financially burdensome, increase defensive practices, and incur a notable emotional toll on defendants. We sought to determine the effect of malpractice lawsuits on professional well-being and self-reported medical errors among orthopaedic surgeons.

Methods:
We surveyed 305 members of the American Orthopaedic Association to collect information on experiences with medical malpractice lawsuits, demographic and practice characteristics, professional well-being on the Professional Fulfillment Index, and self-reported medical errors. Multivariable logistic regression identified predictors of malpractice lawsuits, professional well-being, and self-reported medical errors.

Results:
Seventy-three percent (224 of 305) respondents had been involved in a medical malpractice lawsuit. The odds of experiencing a malpractice lawsuit increased by seven percent with each year in practice (OR = 1.07, 95% CI: 1.04 to 1.10, P < 0.001) and with specialization in spine surgery. Respondents with a lawsuit in 2 years before the survey reported comparable professional well-being and medical error rates with those without a lawsuit. However, compared with respondents without a lawsuit, respondents with a lawsuit more than 2 years in the past were less likely to report burnout (OR = 0.43, 95% CI: 0.20 to 0.90, P = 0.03) and more likely to report a medical error in the past year, which resulted in patient harm (OR = 3.51, 95% CI: 1.39 to 8.91, P = 0.008).

Discussion:
While malpractice lawsuits negatively affect professional well-being, this effect resolves with time. The effect on medical errors may be more permanent; orthopaedic surgeons who have experienced a lawsuit reported greater rates of medical errors even after these legal issues have been settled. Among orthopaedic surgeons dealing with lawsuits, supportive interventions to protect professional well-being and mitigate the factors which lead to greater medical errors are needed.

Level of Evidence:
Prognostic Level III.
Modernisering van de productaansprakelijkheidsrichtlijn: innovatief en baanbrekend?
Authors: Jelsma K.A. , Amiri Bavandpour M. 
Published: June 2023

Modernisering van de productaansprakelijkheidsrichtlijn: innovatief en baanbrekend?
De huidige richtlijn productaansprakelijkheid is al bijna veertig jaar geldend recht. Mede door de technologische ontwikkelingen heeft de Europese Commissie op 28 september 2022 een voorstel voor een herziene en geactualiseerde productaansprakelijkheidsrichtlijn gepubliceerd. Een aantal voorgestelde wijzigingen zullen in de praktijk niet voor veel verandering zorgen, maar een aantal wijzigingen zijn wel degelijk innovatief en baanbrekend. Duidelijk is wel dat veel van de nieuwe voorgestelde regels bedoeld zijn ter bescherming van de gelaedeerde. Potentieel kunnen deze wijzigingen voor betrokken marktdeelnemers leiden tot (veel) meer risico op claims en vordering en aldus hun risico op productaansprakelijkheid vergroten.
De redelijke kosten ter vaststelling van de schade: wie betaalt?
Authors: Bartels L. 
Published: June 2023

De redelijke kosten ter vaststelling van de schade: wie betaalt? HR 9 september 2022, ECLI:NL:HR:2022:1174, NJ 2022/343 (Redelijke kosten schadevaststelling)
In zijn arrest van 9 september 2022 heeft de Hoge Raad zich uitgelaten over de vergoeding van redelijke kosten ter vaststelling van de omvang van de schade als bedoeld in artikel 7:959 lid 1 BW. Aan de orde is onder andere de vraag of relevant is wie de kosten maakt. Ook komt de vraag aan bod welke kosten onder de redelijke kosten ter vaststelling van de schade vallen. In deze bijdrage wordt ingegaan op het oordeel van de Hoge Raad, waarbij ook wordt besproken of in de onderhavige kwestie sprake is van samenloop van verzekeringen.
Platelet Inventory and Using Out-of-group Platelet Suspension: A Cost-Effective Strategy for a Blood Transfusion Service
Authors: Yıldız Abdulkerim , Doğan Murat , Yalvaç Mehmet , Zihar Bilge 
Published: June 2023

Background:
Platelet (PLT) transfusions are essential for advanced hospitals, especially those with onco-hematology departments. However, platelet concentrates (PCs) have supply limitations and a shorter shelf life, which create difficulties for blood transfusion services (TSs).

Materials and methods:
This retrospective study was conducted over a 4-year period between January 2017 and January 2021 in a tertiary referral hospital. From the beginning of 2020, as a new strategy of our TS, a PLT inventory was produced and ABO-identical transfusions were prioritized when the inventory allowed; when this was not possible, ABO and Rh incompatible transfusion was employed. The numbers of transfused and discarded PCs were compared for each year.

Results:
In 2017, a total of 799 PPCs were used and 70 PPCs were discarded with the expiration ratio (ER) of 8.0%. In 2018,1124 PPCs were used and 99 PPCs were discarded with the ER of 7.4%. In 2019, 726 PPCs were used and 91 PPCs were discarded with the ER of 11.1%. In 2020,1100 PPCs were used for 569 patients, of which 251 PPCs were ABO and Rh incompatible without any severe transfusion reaction. A total of 56 PPCs were discarded with the ER of 4.8%.

Conclusion:
The results of the current study suggested that with the determination of the platelet stock level and the use of out-of-group PCs, the rate of discarded PLT could be reduced. Nevertheless, based on current literature and experience, each TSs should make their own strategies and policies to provide an adequate supply of PCs.