bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caracterización espacial de un paisaje de extracción prehispánico: el yacimiento de dacita de Las Minas, Zacapu, Michoacán
Authors: Quezada Ramírez Osiris , Darras Véronique 
Published: April 2023

ResumenEn la cuenca lacustre de Zacapu a lo largo de su ocupación prehispánica (100 a.C. a 1450 d.C.), la dacita, una roca de origen volcánico, fue un recurso estratégico dentro de la economía regional, con el cual los antiguos habitantes de la zona elaboraron una serie de artefactos líticos ligados tanto a actividades de subsistencia y artesanales como rituales. Las investigaciones iniciadas en 2011 en dos minas-taller del yacimiento de dacita del Cerro Vicente expusieron una explotación extensa y organizada en torno a este recurso. En 2015, a partir de la cobertura LiDAR, se identificó un tercer complejo minero con evidencias de una explotación a cielo abierto y subterránea, esta vez en el yacimiento de Las Minas. Con el fin de comprender los mecanismos de explotación de la dacita, se ha llevado a cabo un análisis espacial de este sitio con distintas escalas de aproximación, para caracterizar las evidencias materiales vinculadas con la actividad extractiva. La combinación en nuestra investigación de la información que aporta el LiDAR y la proveniente de la prospección en el campo, nos ofrece un panorama completo del yacimiento, su organización espacial y funcional en un contexto más amplio como un paisaje prehispánico de extracción.
Failure to post-dilate BeSmooth peripheral stents to adult vessel size diameters during benchside tests
Authors: Haddad Raymond N. , Bonnet Damien , Malekzadeh-Milani Sophie 
Published: April 2023

AbstractBackground:Low-profile stent implantation remains a rescue treatment for aortic coarctation and branch pulmonary arteries stenosis in small children. Stent re-expansion to cope with vascular growth remains problematic.Objectives:To evaluate ex vivo feasibility and mechanical behaviour of over-dilating BeSmooth peripheral stents (Bentley InnoMed, Germany).Methods:Three BeSmooth peripheral stents in diameters of 7, 8, and 10 mm were dilated to nominal pressure and then 13 atm. BeSmooth Ø7 × 23 mm was sequentially post-dilated using 12, 14, and 16 mm high-pressure balloons. BeSmooth Ø10 × 57 mm was post-dilated with a 14 mm balloon and then with a 48 mm bare-metal Optimus XXL stent hand-mounted on a 14 mm balloon (stent-in-stent). BeSmooth Ø8 × 57 mm was directly post-dilated with a 48 mm bare-metal Optimus XXL stent hand-mounted on a 16 mm balloon (stent-in-stent). The stents’ diameter and length were measured. Digital inflation pressure was noted. Balloon rupture and stent fracture patterns were closely evaluated.Results:At 20atm pressure, BeSmooth Ø7 × 23 mm shortened to 2 mm forming a 12 mm diameter solid ring circle and the woven balloon ruptured radially. At 10 atm pressure, BeSmooth Ø10 × 57 mm fractured longitudinally in various dispatched breaking points at a diameter of 13 mm without shortening and ruptured the balloon with multiple pinholes. At 10 atm pressure, BeSmooth Ø8 × 57 mm fractured centrally at three different points at a diameter of 11.5 mm without shortening and the balloon broke radially in half.Conclusions:In our benchmark tests, extreme shortening, severe balloon rupture, or unpredictable stent fracture patterns at small balloon diameters limits safe post-dilation of BeSmooth stents beyond 13 mm. BeSmooth stents are not ideal candidates for off-label stent interventions in smaller patients.
How does economic openness affect the relative economic voting?
Authors: Park Brandon Beomseob 
Published: April 2023

AbstractContrary to conventional wisdom, globalization strengthens the linkage between the economy (across-border benchmarked measures) and vote choice, thereby facilitating electoral accountability by enriching the information available to the public. In the pre-globalization era, ordinary citizens had difficulty assessing domestic economic conditions in a comparative setting, in part because they were less exposed to information concerning other countries’ economic performance. However, globalization has provided citizens with excellent sources for comparisons in the form of media coverage. Moreover, openness results in a reduction in relative variance of exogenous rather than competence shocks. Using media-guided comparisons from 29 countries since the 1980s, this study finds that relative economic performance significantly affects citizens’ vote choices when their economy is highly integrated into the world market.
The impact of the COVID-19 pandemic on physical activity and anxiety levels of young mental health patients and their parents
Authors: Vella Fondacaro Daniel , Vella Fondacaro Francesca , Camilleri Nigel 
Published: April 2023

Abstract: Introduction: One restriction measure during the COVID-19 pandemic period was the closure of sport-related facilities, generating substantial anxiety. This study analyzed longitudinal changes in anxiety and physical activity (PA) levels in young people (YP) attending a community child and adolescent mental health service, and their parents/caregivers from 2020 to 2022. Method: This quantitatively driven convergent mixed-methods cohort study utilized validated scoring tools (GAD-7/GLTEQ) as the core quantitative component, and open-ended questions as the supplementary qualitative component. The quantitative and qualitative data were statistically analyzed, and both results were integrated. Questionnaires were distributed in August–October 2020 (Phase 1: At the peak of restriction period), August–October 2021 (Phase 2: During gradual removal of restrictions) and August–October 2022 (Phase 3: When all restrictions were removed). Results: Parent/caregiver’s anxiety levels significantly reduced from Phase 1 to Phase 3. Results revealed non-significant improvements in YP’s PA levels from Phase 1 to Phase 3. PA levels in YP were significantly higher than those of parents/caregivers throughout all Phases. A significant negative correlation was revealed between PA and anxiety levels in parents/caregivers throughout all Phases. The fear of getting infected, lifting of restrictive measures, vaccination benefits, and pandemic-induced social/financial struggles were common themes generated from the qualitative comments. Conclusion: The authors recommend PA promotional campaigns and incentives during such restrictive periods, helping the population’s mental well-being. The high attrition rates in this study may decrease its generalizability. However, the results generated from this innovative study may serve as a platform for future research carried out during traumatic periods.
A North Pacific Meridional Section (U.S. GEOTRACES GP15) of Helium Isotopes and Noble Gases I: Deep Water Distributions
Authors: Jenkins William J. , Doney Scott C. , Seltzer Alan M. , German Christopher R. , Lott Dempsey E. , Cahill Kevin L. 
Published: April 2023

AbstractThe noble gas signature of incoming Pacific Bottom Water (PBW), when compared to North Atlantic Deep Water, indicates the addition of 450 ± 70 GT a−1glacial melt water to form AABW and subsequently PBW. The downstream evolution of this signature between the southern (20°S to equator) and northern (25°–45°N) bottom waters indicates a decrease in sea level pressure around Antarctica over the past two millennia. Vertical profiles of noble gases in the deep Pacific show exponential relationships with depth with scale heights identical to temperature and salinity. Unlike the other noble gases, helium isotopes show evidence of mid‐depth injection of non‐atmospheric helium. Using observed deviations from exponential behavior, we quantify its magnitude and isotope ratio. There is a clear latitude trend in the isotope ratio of this added helium that decreases from a high exceeding 9 RA(atmospheric3He/4He ratio) in the south to around 8 RAnear the equator. North of 30–40°N, it systematically decreases northward to a low of ∼2 RAnorth of 50°N. This decline results from a combination of northward decline in seafloor spreading, release of radiogenic helium from increased sediment thickness, and the possible emission of radiogenic helium through cold seeps along the Alaskan and North American margins. Finally, we derive an improved method of computing the excess helium isotope concentrations and that the distributions of bottom water3HeXS/4HeXSare consistent with what is known about bottom water flow patterns and the input of low3He/4He sedimentary helium.
Influence of Creep Compaction and Dilatancy on Earthquake Sequences and Slow Slip
Authors: Yang Yuyun , Dunham Eric M. 
Published: April 2023

AbstractFluids influence fault zone strength and the occurrence of earthquakes, slow slip events, and aseismic slip. We introduce an earthquake sequence model with fault zone fluid transport, accounting for elastic, viscous, and plastic porosity evolution, with permeability having a power‐law dependence on porosity. Fluids, sourced at a constant rate below the seismogenic zone, ascend along the fault. While the modeling is done for a vertical strike‐slip fault with 2D antiplane shear deformation, the general behavior and processes are anticipated to apply also to subduction zones. The model produces large earthquakes in the seismogenic zone, whose recurrence interval is controlled in part by compaction‐driven pressurization and weakening. The model also produces a complex sequence of slow slip events (SSEs) beneath the seismogenic zone. The SSEs are initiated by compaction‐driven pressurization and weakening and stalled by dilatant suctions. Modeled SSE sequences include long‐term events lasting from a few months to years and very rapid short‐term events lasting for only a few days; slip is ∼1–10 cm. Despite ∼1–10 MPa pore pressure changes, porosity and permeability changes are small and hence fluid flux is relatively constant except in the immediate vicinity of slip fronts. This contrasts with alternative fault valving models that feature much larger changes in permeability from the evolution of pore connectivity. Our model demonstrates the important role that compaction and dilatancy have on fluid pressure and fault slip, with possible relevance to slow slip events in subduction zones and elsewhere.
Southern Ocean Ice‐Covered Eddy Properties From Satellite Altimetry
Authors: Auger Matthis , Sallée Jean‐Baptiste , Thompson Andrew F. , Pauthenet Etienne , Prandi Pierre 
Published: April 2023

AbstractWe investigate statistical properties of surface currents as well as coherent mesoscale eddies in the seasonally ice‐covered Southern Ocean. Based on a recent regional Sea Level Anomaly satellite altimetry data set, we compute Eddy Kinetic Energy (EKE) and detect mesoscale eddies. EKE is about one order of magnitude higher in the northern sector of the subpolar basin and over the continental slope, as compared to the middle of the subpolar gyres. An eddy detection methodology reveals that eddies are distributed evenly in the subpolar Southern Ocean, and their amplitude follows the spatial pattern of EKE. In addition to regional circulation variations, sea ice concentration arises as an important driver of eddy properties. Eddies have low amplitude and density in the pack ice, in particular in the middle of the gyres where the background circulation is unfavorable for instabilities. In contrast, the northern part of the Marginal Ice Zone is favorable for mesoscale eddies, especially cyclonic. There, eddies are stronger and their density is higher than in any other region of the ice‐covered or ice‐free subpolar Southern Ocean. This region is expected to be a site of frontogenesis due to sea ice melt and upwelling generated from interactions between the wind and the sea ice. While many mesoscale eddies will fall below detection level due to the small Rossby radius at high latitudes, these results contribute to understanding the interactions between mesoscale eddies, sea ice, and the background circulation in the subpolar region.
Assessing the Impact of Self‐Lofting on Increasing the Altitude of Black Carbon in a Global Climate Model
Authors: Johnson B. T. , Haywood J. M. 
Published: April 2023

AbstractBlack carbon (BC) absorbs solar radiation, increasing the buoyancy and vertical ascent of absorbing aerosol in the atmosphere. This self‐lofting process has been observed for individual plumes in the troposphere and lower stratosphere but here we show it occurring at broader scales through enhanced large‐scale ascent over BC‐rich regions. This is demonstrated in a pair of simulation using the UKESM1 Earth‐System model where BC aerosols were modeled either with or without the ability to absorb radiation. With absorption included the annual global mean concentration of BC in the upper troposphere and lower stratosphere (8–22 km) rose by up to 50% and the column loading over some remote oceanic regions more than doubled. The increase in aerosol height was particularly notable over the southeast Atlantic where biomass burning aerosol from Africa was elevated up to 1 km higher when their absorption was included. Similar effects were seen over the Arctic where the absorbing haze was transported in at higher levels and surface concentrations were halved. The absorption by BC also increased ascent over southern Asia, which tended to thicken the Asian brown cloud during the dry season but in the wet season enhancing ascent promoted deep convection and had the tendency to deplete the aerosol through wash‐out. We conclude that representing aerosol absorption accurately is important in simulating the vertical distribution, transport and abundance of aerosol in the Earth‐system that will affect their interactions with climate.
Simulation of the Propagation and Effects of Gravity Waves Generated by Tonga Volcano Eruption in the Thermosphere and Ionosphere Using Nested‐Grid TIEGCM
Authors: Wu Haonan , Lu Xian , Wang Wenbin , Liu Han‐Li 
Published: April 2023

AbstractThe Hunga Tonga‐Hunga Ha'apai volcano eruption on 15 January 2022 triggered strong atmospheric gravity wave (GW) activity in the upper atmosphere, which was later detected by various observations. We perform one of the first ionosphere‐thermosphere (I‐T) model studies of the GW effects from the Tonga eruption in the ionosphere‐thermosphereI‐T system using the thermosphere‐ionosphere‐electrodynamics general circulation model (TIEGCM). We implement a high‐resolution mesh inside a regional domain (nested grid) in addition to the global low‐resolution mesh, which differs from the standard global uniform resolution setup. The nested‐grid TIEGCM (TIEGCM‐NG) successfully simulates the observed wave propagation and effects in the I‐T system by further nudging GW fields at TIEGCM lower boundaries (∼97 km) using output from the high‐resolution whole atmosphere community climate model with thermosphere and ionosphere extension simulations. The simulation results indicate that the critical parameter to simulate GW propagation is horizontal resolution. Inside the high‐resolution nested region, GWs with horizontal wavelengths of ∼400 km and periods of 10–30 min can propagate outward and upward and produce significant ionospheric disturbances close to observations. Outside the nested region, only long‐wavelength, low‐frequency waves survive. Another test indicates that GWs can be better resolved when geopotential height is nudged at TIEGCM lower boundaries. With the capability of simultaneously simulating local, small to mesoscale I‐T processes, TIEGCM‐NG is superior to global high‐resolution simulations due to its largely reduced computation cost and may find its application in the study of I‐T system regional dynamics.
Trends in dietary patterns over the last decade and their association with long-term mortality in general US populations with undiagnosed and diagnosed diabetes
Authors: Yuan Sheng , He Jining , Wu Shaoyu , Zhang Rui , Qiao Zheng , Bian Xiaohui , Wang Hongjian , Dou Kefei 
Published: April 2023

Abstract
Background
Dietary management plays an important role in diabetes care, while the trends in dietary patterns over the last decade in US adults with diagnosed and undiagnosed diabetes remain unknown. This study aims to estimate the dietary patterns over the last decade by baseline diabetes diagnoses and explore their association with long-term prognosis.

Methods
Participants’ data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2007–2018, which were divided into three groups according to the diabetes diagnosis: without diabetes, undiagnosed diabetes, and diagnosed diabetes. Healthy eating index (HEI) and dietary inflammatory index (DII) were used to evaluate dietary patterns. Survival analyses were adopted to estimate the association between HEI/DII scores and long-term all-cause mortality and cause-specific mortality.

Results
The prevalence of diabetes was increasing among US adults over the last decade. HEI scores of all three groups presented a downward trend in recent years. Participants with undiagnosed diabetes (weighted mean: 50.58, 95% CI: 49.79, 51.36) got significantly lower HEI score in comparison to participants with diagnosed diabetes (weighted mean: 51.59, 95% CI: 50.93, 52.25). Compared with participants without diabetes, participants in the undiagnosed or diagnosed diabetes group had higher DII scores, indicating a higher dietary inflammatory potential. Survival analysis found a significant association between HEI scores and all-cause mortality and death of heart diseases. Similar correlation was observed in DII scores.

Conclusions
Along with the growth in diabetes prevalence in the US, dietary management of people with diabetes is decreasing. The management of US adults’ diets needs special attention, and dietary inflammatory potential may be considered in the dietary intervention.
Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma
Authors: Kitagawa Akihiro , Osawa Tsuyoshi , Noda Miwa , Kobayashi Yuta , Aki Sho , Nakano Yusuke , Saito Tomoko , Shimizu Dai , Komatsu Hisateru , Sugaya Maki , Takahashi Junichi , Kosai Keisuke , Takao Seiichiro , Motomura Yushi , Sato Kuniaki , Hu Qingjiang , Fujii Atsushi , Wakiyama Hiroaki , Tobo Taro , Uchida Hiroki , Sugimachi Keishi , Shibata Kohei , Utsunomiya Tohru , Kobayashi Shogo , Ishii Hideshi , Hasegawa Takanori , Masuda Takaaki , Matsui Yusuke , Niida Atsushi , Soga Tomoyoshi , Suzuki Yutaka , Miyano Satoru , Aburatani Hiroyuki , Doki Yuichiro , Eguchi Hidetoshi , Mori Masaki , Nakayama Keiichi I. , Shimamura Teppei , Shibata Tatsuhiro , Mimori Koshi 
Published: April 2023

Abstract
Background
Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC need to be understood to develop new treatment strategies. We aimed to unravel the evolution of ICC and identify ICC-specific metabolic characteristics to investigate the metabolic pathway associated with ICC development using multiregional sampling to encompass the intra- and inter-tumoral heterogeneity.

Methods
We performed the genomic, transcriptomic, proteomic and metabolomic analysis of 39–77 ICC tumour samples and eleven normal samples. Further, we analysed their cell proliferation and viability.

Results
We demonstrated that intra-tumoral heterogeneity of ICCs with distinct driver genes per case exhibited neutral evolution, regardless of their tumour stage. Upregulation of BCAT1 and BCAT2 indicated the involvement of ‘Val Leu Ile degradation pathway’. ICCs exhibit the accumulation of ubiquitous metabolites, such as branched-chain amino acids including valine, leucine, and isoleucine, to negatively affect cancer prognosis. We revealed that this metabolic pathway was almost ubiquitously altered in all cases with genomic diversity and might play important roles in tumour progression and overall survival.

Conclusions
We propose a novel ICC onco-metabolic pathway that could enable the development of new therapeutic interventions.
Temporal trends in cardiovascular burden among patients with prostate cancer receiving androgen deprivation therapy: a population-based cohort study
Authors: Chan Jeffrey Shi Kai , Satti Danish Iltaf , Lee Yan Hiu Athena , Hui Jeremy Man Ho , Dee Edward Christopher , Ng Kenrick , Liu Kang , Tse Gary , Ng Chi Fai 
Published: April 2023

Abstract
Background
Although androgen deprivation therapy (ADT) is associated with cardiovascular risks, the extent and temporal trends of cardiovascular burden amongst patients with prostate cancer receiving ADT are unclear.

Methods
This retrospective cohort study analyzed adults with PCa receiving ADT between 1993–2021 in Hong Kong, with follow-up until 31/9/2021 for the primary outcome of major adverse cardiovascular events (MACE; composite of cardiovascular mortality, myocardial infarction, stroke, and heart failure), and the secondary outcome of mortality. Patients were stratified into four groups by the year of ADT initiation for comparisons.

Results
Altogether, 13,537 patients were included (mean age 75.5 ± 8.5 years old; mean follow-up 4.7 ± 4.3 years). More recent recipients of ADT had more cardiovascular risk factors and used more cardiovascular or antidiabetic medications. More recent recipients of ADT had higher risk of MACE (most recent (2015–2021) vs least recent (1993–2000) group: hazard ratio 1.33 [1.11, 1.59], P = 0.002; Ptrend < 0.001), but lower risk of mortality (hazard ratio 0.76 [0.70, 0.83], P < 0.001; Ptrend < 0.001). The 5-year risk of MACE and mortality for the most recent group were 22.5% [20.9%, 24.2%] and 52.9% [51.3%, 54.6%], respectively.

Conclusions
Cardiovascular risk factors were increasingly prevalent amongst patients with prostate cancer receiving ADT, with increasing risk of MACE despite decreasing mortality.
RUVBL1-modulated chromatin remodeling alters the transcriptional activity of oncogenic CTNNB1 in uveal melanoma
Authors: Zhang Chao , Wu Shuai 
Published: April 2023

AbstractRecent years have witnessed an increasing research interest in the therapeutic value of aberrant chromatin regulatory processes in carcinogenesis. Our study was performed to explore the possible carcinogenic mechanism of the chromatin regulator RuvB-like protein 1 (RUVBL1) in uveal melanoma (UVM). The expression pattern of RUVBL1 was retrieved in bioinformatics data. The correlation between RUVBL1 expression and the prognosis of patients with UVM was analyzed in publicly available database. The downstream target genes of RUVBL1 were predicted and further verified by co-immunoprecipitation. The bioinformatics analysis results showed that RUVBL1 may be associated with the transcriptional activity of CTNNB1 by regulating chromatin remodeling, and that RUVBL1 functioned as an independent prognostic factor for patients with UVM. The UVM cells manipulated with RUVBL1 knockdown were introduced for in vitro investigation. CCK-8 assay, flow cytometry, scratch assay, Transwell assay and Western blot analysis were used for detection on the resultant UVM cell proliferation, apoptosis, migration, invasion and cell cycle distribution. In vitro cell experimental data showed that RUVBL1 expression was significantly increased in UVM cells and RUVBL1 knockdown inhibited the proliferation, invasion and migration of UVM cells, accompanied by augmented apoptosis rate and blocked cell cycle progression. To sum up, RUVBL1 enhances the malignant biological characteristics of UVM cells by increasing the chromatin remodeling and subsequent transcription activity of CTNNB1.