bluuebunny/crossref_metadata_2025_split huggingface dataset:
Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate‐binding pocket
Authors: Wang Jie , Li Xu , Wang Fang‐Fang , Cheng Meng‐Ting , Mao Yao‐Xu , Fang Shu‐Cheng , Wang Liang , Zhou Cong‐Zhao , Hou Wen‐Tao , Chen Yuxing 
Published: July 2023

AbstractThe human ABC transporter ABCC3 (also known as MRP3) transports a wide spectrum of substrates, including endogenous metabolites and exogenous drugs. Accordingly, it participates in multiple physiological processes and is involved in diverse human diseases such as intrahepatic cholestasis of pregnancy, which is caused by the intracellular accumulation of bile acids and estrogens. Here, we report three cryogenic electron microscopy structures of ABCC3: in the apo‐form and in complexed forms bound to either the conjugated sex hormones β‐estradiol 17‐(β‐D‐glucuronide) and dehydroepiandrosterone sulfate. For both hormones, the steroid nuclei that superimpose against each other occupy the hydrophobic center of the transport cavity, whereas the two conjugation groups are separated and fixed by the hydrophilic patches in two transmembrane domains. Structural analysis combined with site‐directed mutagenesis and ATPase activity assays revealed that ABCC3 possesses an amphiphilic substrate‐binding pocket able to hold either conjugated hormone in an asymmetric pattern. These data build on consensus features of the substrate‐binding pocket of MRPs and provide a structural platform for the rational design of inhibitors.
The Effect of Financial Literacy, Income and Self Control on Financial Behavior Generation Z (Study on Generation Z Financial Behavior in Bekasi Regency)
Authors: Trivani Gea , Soleha Erin 
Published: July 2023

Financial behavior is an important thing to pay attention to, with good financial behavior a person will beable to meet his needs both from the short and long term. The purpose of this study was to determine and analyze the effect of financial literacy, income and self-control on thelimited financial behavior of generation Z. The population of this study is generation Z in Bekasi Regency. This studyused quantitative research with data collection techniques using questionnaires. The sampling technique in this study is by using urposive sampling techniques, so that the number of samples inthis study was 100 respondents. And the technique of data analysis inthis research is using Structural Equation Modelling (SEM) withthe help of SmartPLS version 4.0 for windows. The results of this study found that financial liability variables have a negative and insignificant effect on financial behavior in generation Z in Bekasi Regency, income variables have a positive and significant effect on financial behavior in generation Z in Bekasi regency.ini show that income can increase financial behavior in generation Z in Bekasi regency, where the higher a person's income level, the more Be careful about using money. In managing finances, generation Z must remember that both large and small income they have from working and investing, they still have to manage their finances well. Then the variable of self-control has a positive and significant effect on financial behavior. This means that the higher the self-control, the better the financial behavior.
Caregiver Perspectives on Social Needs Screening and Interventions in an Urban Children’s Hospital
Authors: Luke Michael J. , Fernandes Danielle M. , Leon Rodriguez Florangel De , Acholonu Rhonda G. , Fiori Kevin 
Published: July 2023

OBJECTIVES
Caregiver opinions of inpatient social needs screening and ways of addressing positive screens are not well understood. We aimed to explore caregiver perspectives and goals surrounding inpatient screening and determine how helpful provided resources are at meeting these goals.

METHODS
We conducted a qualitative study using semistructured interviews with caregivers of pediatric patients admitted to an urban tertiary care children’s hospital from April to August 2021. English- and Spanish-speaking caregivers who screened positive for at least 1 social need on a standardized 10-item questionnaire were invited to participate in an interview 2 to 4 months after discharge. Interviews were recorded, transcribed, and analyzed by 2 independent coders using rapid qualitative methods.

RESULTS
We completed 20 interviews, with 14 English-speaking and 6 Spanish-speaking caregivers. Four themes emerged: (1) All caregivers expressed support for inpatient social needs screening. (2) Many caregivers cited it as an effective means to support families and help providers better understand their social situation. (3) Caregivers who recalled receiving a resource packet found it useful and at times even shared the resources with others. (4) The majority of caregivers expressed interest in longitudinal support, such as contact after discharge.

CONCLUSIONS
Caregivers are in support of inpatient screening as a means for providers to optimize comprehensive care that explores how unmet social needs influence health. Although inpatient social work and resource packets may be helpful, longitudinal support after discharge may improve the effectiveness of social needs interventions, patient outcomes, and caregiver satisfaction.
Childhood and Adolescent Television Viewing and Metabolic Syndrome in Mid-Adulthood
Authors: MacDonell Nathan , Hancox Robert J. 
Published: July 2023

BACKGROUND
Excessive sedentary behaviors, such as television viewing or other screen time, may have adverse metabolic effects. We hypothesized that television viewing time in childhood would be associated with the risk of metabolic syndrome at 45 years of age.

METHODS
We studied a population-based birth cohort born in Dunedin, New Zealand in 1972 and 1973. Parent- and self-reported weekday television viewing times were recorded at ages 5, 7, 9, 11, 13, 15, and 32 years. The primary outcome was metabolic syndrome at age 45 years, defined as 3 or more of: high glycated hemoglobin; high waist circumference; high blood triglyceride; low high-density lipoprotein cholesterol; and high blood pressure. Reported television viewing time and metabolic syndrome data were available for 870 (87%) of 997 surviving participants.

RESULTS
Mean television viewing time between ages 5 and 15 years was associated with metabolic syndrome at 45 years of age. This association persisted after adjusting for sex, socioeconomic status, and BMI at age 5 (odds ratio: 1.30; 95% confidence interval: 1.08 to 1.58; P = .006) and after further adjustment for adult television viewing (odds ratio: 1.26; 95% confidence interval: 1.03 to 1.54; P = .026). Childhood television viewing was also associated with lower cardiorespiratory fitness and higher BMI at 45 years of age.

CONCLUSIONS
Time spent watching television during childhood and adolescence is associated with the risk of metabolic syndrome in mid-adulthood. Interventions to reduce screen time for children and young people may have long-lasting benefits for health.
Improvement of subgrade soil with sand columns for construction railway embankment: A case study
Authors: Abbas Basim Jabbar , Alsheakayree Talib K. Q. , Al Khuzaie Hussain M. Ashour , Sultan Hussein Kareem 
Published: July 2023

AbstractA railway on 4 m height embankment is being built in the south of Iraq. The railway alignment is extending on a compressible soil experienced impermissible settlement according to the results of soil investigation of the soil at the project site. A trial for reducing the settlement was done adopting sand piles. Nonlinear analysis was conducted to evaluate the settlement of soil before and after using the proposed technique.The results indicated that without any improvement, the expected total settlement of the railway embankment on the compressible clay layer is 170.2 mm. By inserting granular piles of diameter 0.3 m, it was obtained settlement decreases to 88.7 mm with reduction being in range of ∼48%.
Clinicopathological Characteristics of Cervical Carcinoma with Pelvic Lymph Node Metastases in Dr. Hasan Sadikin General Hospital, Bandung 2013-2021
Authors: Sri Rejeki Henny , Suryanti Sri , Yantisetiasti Anglita , Mantilidewi Kemala I. , Winarno Gatot Nyarumenteng Adhipurnawan 
Published: July 2023

Background: Carcinoma of the cervix is the most common gynecological malignancy, which ranks first among carcinomas in Indonesia. Lymph node metastasis is a risk of recurrence, affecting survival and therapy. The purpose of this study was to determine the clinicopathological characteristics of cervical carcinoma with pelvic lymph node metastasis that had undergone radical hysterectomy and lymphadenectomy at Dr. Hasan Sadikin General Hospital, Bandung.Methods: This study used a cross-sectional retrospective descriptive study. Data on the clinical stage I-II cervical cancer patients with pelvic lymph node metastasis were collected from the archives of the pathological anatomy laboratory during period from 2013 to 2021. Data were presented in percentage.Results: There were 64 data patients, and the most common age of cervical carcinoma ranged from 40 to 50 years old (51.6%), the most common stage was stage II (62.5%), and the most frequent histopathological type was squamous cell carcinoma (70.3%). The highest degree of differentiation was moderate differentiation (35.9%). The most frequently found tumor size was ≥4 cm (54.7%).Conclusion: The cases of cervical carcinoma at Dr. Hasan Sadikin General Hospital Bandung were treated with radical hysterectomy and lymphadenectomy. The patients generally aged between 41-50 years old, stage II, squamous cell carcinoma with a moderate degree of differentiation and tumor diameter around ≥ 4 cm.
What Are the Various Comprehensive Treatment Models to Improve Self-Efficacy and Self-Management in Adolescents with Diabetes Mellitus? A Scoping Review
Authors: Prasetyawati Arsita Eka , Probandari Ari , Claramita Mora , Julia Madarina 
Published: July 2023

Background: This review aimed to synthesize intervention models involving the role of adolescent and family support as part of comprehensive care to improve self-efficacy and self-management among adolescents with Diabetes Mellitus (DM).
Methods: A review was conducted to conform to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) standards. We searched PubMed, Research Gate, Science Direct, Cochrane Library databases, and grey literature. We included articles exploring family intervention models on improving self-efficacy and self-management among adolescents with DM, published from January 1, 2009, to June 30, 2022, and in English. Articles were declared eligible, reviewed critically, and then synthesized narratively.
Results: We identified 487 abstracts and title records from the initial search and excluded 409 irrelevant studies. Sixty-six full-text articles were screened, and nine were included in the synthesis. Five articles presented findings from using models focusing on child and adolescent intervention, while in the remaining four articles, the intervention models involved adolescents and their caregivers or parents. Only two models provide comprehensive care that requires collaboration among healthcare providers, patients, and families. Adolescent self-efficacy and self-management schemes as intermediary variables are closely related to everything that can influence health behavior, metabolic control, and quality of life for adolescents, which requires support from a multidisciplinary collaborative team.
Conclusion: Excellent comprehensive care team collaboration involving family support is essential to increase the self-efficacy and self-management of adolescents with DM.
Piroliza metanu – wpływ wybranych parametrów na przebieg procesu
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Wojtasik Michał , Burnus Zygmunt ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Markowski Jarosław ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy, Żak Grażyna ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy, Lubowicz Jan ,   Instytut Nafty i Gazu - Państwowy Instytut Badawczy
Published: July 2023

Piroliza metanu jest metodą otrzymywania wodoru z metanu, która coraz częściej zyskuje zainteresowanie naukowców oraz inwestorów z sektora gospodarki. Technologia ta jest alternatywą dla reformingu parowego – obecnie najczęściej stosowanej metody produkcji wodoru. Pomimo wielu zalet reforming parowy jest procesem, w trakcie którego powstają znaczne ilości ditlenku węgla. Dlatego trwają poszukiwania nowej, wydajnej metody produkcji wodoru. Oprócz elektrolizy wody, pirolizy biomasy wydaje się, że to właśnie piroliza metanu jest najbardziej obiecującą technologią. Metoda ta ma wiele zalet, jest prosta, szybka, uzyskany wodór cechuje się wysoką czystością, jednak największą jej zaletą jest brak ubocznej produkcji ditlenku węgla, co korzystnie wpływa na ocenę zrównoważenia tego procesu. Rozkład metanu przeprowadza się w reaktorach rurowych w temperaturze 600–1200°C, w zależności od rodzaju procesu. W procesie pirolizy obok wodoru powstają proporcjonalne ilości czystego węgla o różnorodnej morfologii oraz różnym poziomie grafityzacji. W pracy przedstawiono charakterystykę stanowiska do pirolizy metanu zbudowanego w 2022 r. w Zakładzie Zrównoważonych Technologii Chemicznych INiG – PIB. Stanowisko pozwala na prowadzenie prób pirolizy metanu w temperaturze do 1100°C. Maksymalna teoretyczna wydajność tej instalacji to 400 ml H2/minutę. Przeprowadzono wstępne próby działania pieca rurowego, wyposażonego w rurowy reaktor kwarcowy o pojemności 6,8 dm3. Opisano próby termicznego rozkładu metanu w zakresie temperatur 600–1050°C. Za pomocą metod chromatograficznych zbadano zawartość metanu, wodoru, azotu, tlenu oraz sumy węglowodorów C2 i C3 w gazach poprocesowych. Wytypowano zmienne mogące mieć wpływ na rezultaty pirolizy. Sprawdzono wpływ temperatury, czasu reakcji, strumienia surowca oraz składu mieszanki gazów procesowych w wybranych zakresach. Potwierdzono zależności pomiędzy temperaturą i szybkością przepływu substratu a wydajnością procesu.
Social work teaching and learning in the era of COVID-19: Lessons for the future
Authors: Mackle Danielle , Montgomery Lorna , Kelly Berni 
Published: July 2023

In 2020, the UK and Ireland, and indeed most countries across the globe, found themselves unprepared to deal with a worldwide pandemic (BASW, 2020; Mellish et al., 2020). Indeed, in the UK and Ireland, health and social care workers had to respond to unprecedented situations and adapt quickly and extensively to the health, social and economic dimensions of the crisis (Egan et al., 2020; BASW,2020). It is timely, then, to consider the role of the social worker and the impact on social work training for undergraduate students in light of the changes that have taken place as a result of the global pandemic. The COVID-19 restrictions led to the rise of new forms of social engagement and interaction, as well as the need for professionals, including social workers, to develop new digital skills. This paper will draw on the findings from an online survey (using qualitative and quantitative question sets) conducted with 30 undergraduate social work students in 2021. The survey explored student experiences of online teaching during their ‘preparation for practice learning’ module and the extent to which this online teaching prepared them for their practice learning opportunity (PLO) that followed during a time of strict COVID-19 measures, including social distancing. Recent research has been conducted that highlights the benefits of blended learning (online and face-to-face) as a strong pedagogical approach (Finlay et al., 2022; Karma et al., 2021). As we transition back to face-to-face teaching and learning, this paper will consider the implications of online learning for social work students, analyse the benefits and limitations of this to the learning and practice environment and capture the lessons to hold on to for the future.
Diagnostic Reference Levels in Interventional Pediatric Cardiology: Two-Year Experience in a Tertiary Referral Hospital in Latin America
Authors: Aristizabal Ana M , Gutiérrez Jaiber A , Ramirez Emmanuel , Mejía-Quiñones Valentina , Ubeda Carlos , Mosquera Walter Fernando , Mosquera Walter 
Published: July 2023

This work presents patient radiation dose data for pediatric interventional cardiology procedures in a large hospital in Colombia.
The data collection period was from April 2020 to July 2022. The local DRLs were calculated as the 3rd quartile of patient dose data distributions for kerma area-product (Pka) values. The sample of collected clinical procedures (255) was divided into diagnostic and therapeutic procedures and grouped into five weight and five age bands.
The Pka differences found between diagnostic and therapeutic procedures were statistically in all weight and age bands, except the group between 1-5 years. The local DRLs were 69 Gy/cm2 (&lt; 5 kg), 3.44 Gy/cm2 (5-&lt;15 kg), 8.87 Gy/cm2 (15-&lt;30 kg), 10.51 Gy/cm2 (30-&lt;50 kg) y 22.61 Gy/cm2 (50-&lt;80 kg), respectively.
In conclusion, from comparing our results with other existing DRL values, we are similar to other centers and scope to continue optimizing the radiation dose values. This will contribute to setting national diagnostic reference levels (DRLs) for Colombia in the near future.
Efectos del aula invertida en el rendimiento académico en cursos de Física: una revisión sistemática
Authors: Muñoz Jiménez Wilton , Tamayo Ancona Martín E. 
Published: July 2023

En esta revisión sistema de intervención se analizó la evidencia existente sobre el efecto de la metodología de aula invertida (FC) en el rendimiento académico en cursos de Física de educación secundaria y universitaria. A partir de una búsqueda en cinco bases de datos y buscadores: Scopus, Web of Science (WOS), ERIC, Google Académico y Google Chrome, de un total de 425 registros inicialmente encontrados se seleccionaron 22 artículos para su revisión. En la mayoría de los estudios (n = 20), se evidenció una mayor ganancia de aprendizaje en los cursos de Fisica donde se implementó alguna modalidad de FC en comparación con aquellos donde se utilizó el método tradicional de enseñanza u otro enfoque. Además, se reportaron mejoras en la motivación, comprensión conceptual, habilidades tecnológicas, autonomía en el aprendizaje y autoconcepto, y un alto grado de aceptación del FC en el alumnado. En conclusión, la evidencia analizada sugiere que el aula invertida mejora significativamente el rendimiento académico en los cursos de Física.
Geochemistry and Mineralogy of Rare-Earth Elements in Ferruginous Deposits and Bottom Sediments of the Laptev Sea
Authors: Kolesnik O.N. , Kolesnik A.N. , Astakhov A.S. 
Published: July 2023

Abstract
—The geochemical and mineralogical aspects of the distribution of rare-earth elements (REE) in ferruginous deposits (FD) and bottom sediments of the southeastern Laptev Sea are analyzed. The FD are dominated by biomorphs developed after polychaete tubes. The REE patterns depend on the proportion of ore and non-ore substances. The ore substance is represented mainly by iron hydroxides (limonite). It is a product of suboxic diagenesis enhanced by bioturbation and determines the slight enrichment of FD in MREE and cerium deficiency (Cean = 0.94). The non-ore substance comes from terrigenous sediments and has an (alumino)silicate composition. It controls the scandium content and is the source of REE mineral grains, among which monazite-(Ce) prevails. The sediments demonstrate a common similarity in REE patterns to shales and suspended material transported to the Laptev Sea by the Lena River, with elevated LREE and MREE contents and the value of Ce anomaly almost equal to unity (Cean = 1.06). In the sediments, REE minerals occur mostly in the silt fraction (&lt;63 μm in size). The high content of organic matter (Corg of up to 2.15%) of predominantly terrigenous origin (OMter of up to 85%) in the sediments explains the oxygen deficiency and weak diagenetic mineral formation with low accumulation of trace elements, including REE, in the FD. The total REE content in the FD is lower than that in the sediments (on average, 173 ppm against 206 ppm).
Improving Smart Irrigation Systems through Energy Efficient Cluster-Head Selection in Heterogeneous WSNs
Authors: Hassan Emad , Oshaba Ahmed , Elemary Atef 
Published: July 2023

Abstract

Smart irrigation systems require reliable and energy-efficient communication between the sensors in a Wireless Sensor Network (WSN) and the control system. To address this challenge, this paper presents several cluster-based selection protocols, based on the Stable Election Protocol (SEP) and Distributed Energy-Efficient Clustering (DEEC). The presented protocols divide the agriculture field into sub-fields to reduce energy consumption between far sensors and the base station (BS). Comparison with traditional protocols using evaluation metrics such as network throughput, stability, instability period, and lifetime, shows that the presented protocols outperform in terms of all metrics. The results indicate the effectiveness of the proposed protocols in prolonging the network's lifetime and improving energy efficiency in heterogeneous WSNs, thus supporting the performance of smart irrigation systems.
The SIR epidemic model with diffusion and nonlinear incidence: a symmetry approach
Authors: Naz R , Johnpillai A , Mahomed F , Omame A 
Published: July 2023

Abstract

We use Lie point symmetries to obtain reductions and closed-form solutions for the
diffusive SIR epidemic model with diffusion and nonlinear incidence. We determine
that the Lie algebra for this model is three-dimensional. We invoke these to establish
closed-form solutions of the diffusive SIR model. Furthermore, we utilized the closedform
solutions to generate a graphical representation of the infected curve, and
carried out a sensitivity analysis to gain valuable insights into the transmission
dynamics of the epidemic. Additionally, the most general Lie symmetry generator
is used to find the reductions and numerical solutions.