bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial, Ethnic, and Socioeconomic Disparities in Burn Care Access: A Single-Center Retrospective Study
Authors: Tomtschik Julia , Sweitzer Keith , Cook Caitlin , O’Shea Aidan , Bell Derek 
Published: July 2023

Abstract
While racial, ethnic, and socioeconomic disparities in burn care have been identified in the literature, there is a paucity of research into specific underlying causes of these disparities. Here, we sought to characterize whether time to initial burn consult might contribute to racial, ethnic, and socioeconomic differences in burn care outcomes. We performed a retrospective review of all patients evaluated by the burn surgery service at a single regional ABA-verified burn center between June 2020 and April 2022. Patients without data for the time of onset of burn injury were excluded. Time to burn consult was defined as the time from onset of burn injury to the time of first burn consult. Three hundred and sixty-five patients met the inclusion criteria. Average age was 33.3 years, and 65.8% of patients were male. Average time to burn consult for all patients was 17 hours and 07 minutes. There were no significant differences in this variable among our cohort when stratified by race, ethnicity, or insurance status. Rates of surgical management (Chi-squared P = 0.05) and length of stay (ANOVA P &lt; 0.0001) significantly differed by insurance status, but not among racial or ethnic groups. Medicare patients had the highest rates of surgical intervention and longer hospital stays; patients without insurance had the lowest rates of surgical intervention and shorter hospital stays. These results indicate that time from burn onset to burn consult is unlikely to contribute meaningfully to racial, ethnic, and socioeconomic disparities in burn care. Further studies are needed to better understand other aspects of burn care that may contribute to the noted disparities.
Advance algorithm for two-dimensional fibrous-network generation
Authors: Kayali Yagiz , Gleadall Andrew , Silberschmidt Vadim V , Demirci Emrah 
Published: July 2023

Abstract
Fibrous networks are abundant in nature and commonly used in industry. However, their geometrical modelling is challenging due to their complex microstructure. In this study, a novel method, called fibre placement method (FPM), is developed. In contrast to the existing methods, the FPM has various advantages, such as a fully parametric definition of structure. Also, this method is superior in mimicking the stochastic microstructure of fibrous networks compared with other schemes. Various fibrous networks can be generated easily by employing a user-friendly graphical user interface. Also, the generated fibrous networks are compatible with analysis software such as computer-aided engineering tools. Finally, this algorithm characterizes various features of networks including uniformity, void area fraction, and average curliness.
Investigation of urban active faults using the short-offset transient electromagnetic method: an example from Shunping, Hebei Province, China
Authors: Song Wanting , Chen Weiying , He Yiming , Lei Kangxin , Lv Pengfei , Zhao Yang 
Published: July 2023

Abstract
The presence of an urban active fault carries a geological hazard risk that threatens urban construction. Therefore, detecting such faults is crucial for mitigating potential risks and ensuring safe urban development. The grounded-wire source short-offset transient electromagnetic method (SOTEM) offers an opportunity to identify faults with high-conductivity. The results of a SOTEM survey conducted in Shunping, Hebei Province, were presented to detect buried faults and locate the industrial park. Data were analysed using the one-dimensional inversion method with SOTEMsoft software, which was denoised using the short-time sliding window adaptive singular value decomposition algorithm based on the wavelet threshold. Despite the challenges posed by urban features, particularly traffic, the survey results located the fault and hold significant potential to reveal its extent and depth. The study highlights the importance of avoiding fault sites during urban construction, even though the area is currently tectonically stable. This paper reveals an unusual opportunity to study the effectiveness of electromagnetic methods for detecting buried faults in cities and reveal geological structures covered by Quaternary formations.
Climate Change Litigation before the African Human Rights System: Prospects and Pitfalls
Authors: Suedi Yusra , Fall Marie 
Published: July 2023

AbstractAfrica is a promising regional venue for climate change-related complaints—not least because it is distinctively vulnerable to climate harms. Yet, neither the African Commission on Human and Peoples’ Rights nor the African Court of Human and Peoples’ Rights have been theatres to such disputes at the time of writing. In anticipation that climate litigation will emerge before the African human rights system, this practice note provides information to the non-State actors and their lawyers on the procedural challenges that may arise, demonstrating how such challenges may be circumventable in the African context.
Human γδ T cell identification from single-cell RNA sequencing datasets by modular TCR expression
Authors: Song Zheng , Henze Lara , Casar Christian , Schwinge Dorothee , Schramm Christoph , Fuss Johannes , Tan Likai , Prinz Immo 
Published: July 2023

Abstract
Accurately identifying γδ T cells in large single-cell RNA sequencing (scRNA-seq) datasets without additional single-cell γδ T cell receptor sequencing (sc-γδTCR-seq) or CITE-seq (cellular indexing of transcriptomes and epitopes sequencing) data remains challenging. In this study, we developed a TCR module scoring strategy for human γδ T cell identification (i.e. based on modular gene expression of constant and variable TRA/TRB and TRD genes). We evaluated our method using 5′ scRNA-seq datasets comprising both sc-αβTCR-seq and sc-γδTCR-seq as references and demonstrated that it can identify γδ T cells in scRNA-seq datasets with high sensitivity and accuracy. We observed a stable performance of this strategy across datasets from different tissues and different subtypes of γδ T cells. Thus, we propose this analysis method, based on TCR gene module scores, as a standardized tool for identifying and reanalyzing γδ T cells from 5′-end scRNA-seq datasets.
Diet selection, commonness, and rarity in a pair of smooth-toothed pocket gophers
Authors: Brito Brittany T , Bjornlie Nichole L , Carling Matthew D , Goheen Jacob R 
Published: July 2023

Abstract
Understanding the determinants of species rarity is a perennial challenge for ecologists and conservation biologists. In addition to resource specialization, competitive interactions may limit the abundance and distribution of species, thereby accentuating rarity. However, resource partitioning can reduce or altogether offset such competitive effects, and thus permit species to thrive alongside more common, widespread competitors within a narrow range of environmental conditions. In south-central Wyoming, the Wyoming Pocket Gopher (Thomomys clusius) is restricted to areas dominated by Gardner’s Saltbush (Atriplex gardneri); it inhabits a geographic range that is entirely encompassed by a relatively abundant and widespread congener (T. talpoides, the Northern Pocket Gopher). However, the consumer–resource dynamics underlying the relationships among Wyoming pocket gophers, northern pocket gophers, and Gardner’s Saltbush are poorly understood. We assessed one dimension of consumer–resource interactions—diet selection—between Wyoming pocket gophers, northern pocket gophers, and Gardner’s Saltbush, using a combination of path analysis, DNA metabarcoding, and cafeteria-style feeding experiments. We rejected the null hypothesis that Wyoming pocket gophers and Gardner’s Saltbush co-occur solely because they require similar soil conditions. Although we could not distinguish between obligate and facultative specialization by Wyoming pocket gophers, the checkerboard-like distributions of these two Thomomys likely reflect the outcome of selection and avoidance of Gardner’s Saltbush. We suggest that Wyoming pocket gophers can persist within their small geographic range by capitalizing on Gardner’s Saltbush, a halophyte that probably requires some combination of physiological, morphological, and behavioral adaptations to exploit. Low abundances, restricted geographic ranges, or both are hallmarks of rarity, each of which are shaped by diet selection and other consumer–resource interactions. Quantifying consumer–resource interactions can therefore provide a mechanistic basis for the further refinement and testing of hypotheses on the abundance and distribution of closely related species.
Garbage in may not equal garbage out: sex mediates effects of ‘junk food’ in a synanthropic species
Authors: Ng Elizabeth M , Pidgeon Anna , West Elena H , Peery M Zachariah , Brunk Kristin M 
Published: July 2023

AbstractHuman influence on ecosystems is rapidly expanding, and one consequence is the increased availability of human food subsidies to wildlife. Human food subsidies like refuse and food scraps are widely hypothesized to be ‘junk food’ that is nutritionally incomplete; however, the impacts of ‘junk foods’ on the health and fitness of individual organisms remain unclear. In this study, we aimed to understand how human food consumption affects the body condition and fecundity of a generalist predator, the Steller’s jay (Cyanocitta stelleri). We used stable isotope analysis to quantify individual human food consumption (using δ13C as a proxy), estimated individual body condition based on body mass and feather growth bar width and assessed jay fecundity. Adults consumed more human food than juveniles on average, and we observed sex-specific responses to human food use where male body condition tended to increase, whereas female body condition tended to decline with human food consumption. However, fecundity was not strongly related. Thus, we found some evidence for the ‘junk food’ hypothesis in this system, which suggests that human foods may not be an equal replacement for natural foods from a nutritional perspective, especially for females. Human foods tend to be carbohydrate rich, but protein poor, which may benefit males because they are larger and limited overall by calorie intake. Females, particularly reproducing females, are more nutritionally limited and thus may experience fewer benefits from ‘junk food’. Our study advances knowledge of human–wildlife interactions by increasing the resolution of our understanding of the fitness benefits, or detriments, experienced by individuals that consume human foods.
Mapping Polar Distortions using Nanobeam Electron Diffraction and a Cepstral Approach
Authors: Holtz Megan E , Padgett Elliot , Johnston-Peck Aaron C , Levin Igor , Muller David A , Herzing Andrew A 
Published: July 2023

Abstract
Measuring local polar ordering is key to understanding ferroelectricity in thin films, especially for systems with small domains or significant disorder. Scanning nanobeam electron diffraction (NBED) provides an effective local probe of lattice parameters, local fields, polarization directions, and charge densities, which can be analyzed using a relatively low beam dose over large fields of view. However, quantitatively extracting the magnitudes and directions of polarization vectors from NBED remains challenging. Here, we use a cepstral approach, similar to a pair distribution function, to determine local polar displacements that drive ferroelectricity from NBED patterns. Because polar distortions generate asymmetry in the diffraction pattern intensity, we can efficiently recover the underlying displacements from the imaginary part of the cepstrum transform. We investigate the limits of this technique using analytical and simulated data and give experimental examples, achieving the order of 1.1 pm precision and mapping of polar displacements with nanometer resolution.
High-Resolution Cathodoluminescence Images of Igneous and Metamorphic Monazite
Authors: Yang Saihong , Chen Yi , Li Xianhua , Tang Xu , Liu Jingbo , Mao Qian , Aung Me Me 
Published: July 2023

Abstract
Monazite is one of the most important dating accessory minerals for deciphering geological processes. The growth history of monazite can be identified by its internal structure; thus, high-resolution imaging is necessary for in situ U–Th–Pb dating. In this study, cathodoluminescence (CL) techniques were optimized via the key parameters of working distance, accelerating voltage, and beam current and were then applied to monazites from igneous and metamorphic rocks. The CL images of igneous monazites show concentric oscillatory zoning, whereas those of metamorphic monazites clearly show homogeneous, patchy, or core–rim structures. CL imaging is a more effective approach than back-scattered electron (BSE) imaging for the observation of the internal structure of monazite and may yield additional information. CL can add to the interpretation of X-ray maps and the two techniques that may complement each other. The CL spectra of monazite consist of broad peaks and sets of narrow emission rare earth element 3+ (REE3+) peaks (Gd3+, Tb3+, Dy3+, and Sm3+). The microstructures observed via CL imaging techniques can show a certain relationship between light REE (LREE) and U, Th, and Si in some igneous monazites and heavy REE (HREE) variation in some metamorphic monazites.
COMPREHENSIVE MULTIPLATFORM ANALYSIS OF CDKN2A ALTERATIONS IN MENINGIOMAS
Authors: Wang Justin Z , Patil Vikas , Liu Jeff , Dogan Helin , Tabatabai Ghazaleh , Behling Felix , Hoffman Elgin , Bunda Severa , Yakubov Rebecca , Kaloti Ramneet , Brandner Sebastian , Gao Andrew , Gadol Aaron-Cohen , Barnholtz-Sloan Jennifer , Skardelly Marco , Tatagiba Marcos , Raleigh David , Sahm Felix , Boutros Paul C , Aldape Kenneth ,   The International Consortium on Meningiomas (ICOM), Nassiri Farshad , Zadeh Gelareh 
Published: July 2023

Abstract
BTFC travel award recipient
In meningiomas, CDKN2A/B deletions are associated with poor clinical outcomes but are exceeding rare in most cohorts (1-5% of cases). Large molecular datasets are therefore required to explore these deletions and their relationship to other CDKN2A alterations that may be more common, but also prognostic on a transcriptomic, epigenomic, and/or copy number level.
METHODS: We used multidimensional molecular data of 560 meningioma samples from 5 independent cohorts to comprehensively interrogate the spectrum of CDKN2A alterations through DNA methylation, copy number variation, transcriptomics, and proteomics using an integrated molecular approach, and utilized preclinical models to validate our findings. RESULTS: Meningiomas with either CDKN2A/B deletions (partial or homozygous loss) or an intact CDKN2A gene locus but elevated mRNA expression (CDKN2Ahigh) both had poor clinical outcomes. Increased CDKN2A mRNA expression was a poor prognostic factor independent of deletion status. CDKN2A expression and p16 protein also progressively increased with tumor grade and more aggressive molecular and methylation groups. CDKN2Ahigh meningiomas and meningiomas with CDKN2A deletions were enriched for similar cell cycling pathways but dysregulated at different checkpoints (G1/S vs G2/M). p16 immunohistochemistry was unreliable in differentiating between meningiomas with and without CDKN2A deletions, but increased positivity was associated with mRNA expression. CDKN2Ahigh meningiomas were associated with gene hypermethylation, Rb-deficiency, and lack of response to CDK inhibition. CONCLUSIONS: In meningiomas, CDKN2A mRNA expression consistently increases with biological aggressiveness, is prognostic independent of copy number loss, and may be used as an important prognostic biomarker with therapeutic implications for resistance to CDK4/6 inhibitors clinically.
Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma
Authors: Richardson Timothy E , Yokoda Raquel T , Rashidipour Omid , Vij Meenakshi , Snuderl Matija , Brem Steven , Hatanpaa Kimmo J , McBrayer Samuel K , Abdullah Kalil G , Umphlett Melissa , Walker Jamie M , Tsankova Nadejda M 
Published: July 2023

Abstract

Background
Mutations in mismatch repair (MMR) genes (MSH2, MSH6, MLH1, and PMS2) are associated with microsatellite instability and a hypermutator phenotype in numerous systemic cancers, and germline MMR mutations have been implicated in multi-organ tumor syndromes. In gliomas, MMR mutations can function as an adaptive response to alkylating chemotherapy, although there are well-documented cases of germline and sporadic mutations, with detrimental effects on patient survival.

Methods
The clinical, pathologic, and molecular features of 18 IDH-mutant astrocytomas and 20 IDH-wild-type glioblastomas with MMR mutations in the primary tumor were analyzed in comparison to 361 IDH-mutant and 906 IDH-wild-type tumors without MMR mutations. In addition, 12 IDH-mutant astrocytomas and 18 IDH-wild-type glioblastomas that developed MMR mutations between initial presentation and tumor recurrence were analyzed in comparison to 50 IDH-mutant and 104 IDH-wild-type cases that remained MMR-wild-type at recurrence.

Results
In both IDH-mutant astrocytoma and IDH-wild-type glioblastoma cohorts, the presence of MMR mutation in primary tumors was associated with significantly higher tumor mutation burden (TMB) (P &lt; .0001); however, MMR mutations only resulted in worse overall survival in the IDH-mutant astrocytomas (P = .0069). In addition, gain of MMR mutation between the primary and recurrent surgical specimen occurred more frequently with temozolomide therapy (P = .0073), and resulted in a substantial increase in TMB (P &lt; .0001), higher grade (P = .0119), and worse post-recurrence survival (P = .0022) in the IDH-mutant astrocytoma cohort.

Conclusions
These results suggest that whether present initially or in response to therapy, MMR mutations significantly affect TMB but appear to only influence the clinical outcome in IDH-mutant astrocytoma subsets.
Immune Response Kinetics Following a Third Heterologous BNT162b2 Booster Dose After Primary 2-Dose ChAdOx1 Vaccination in Relation to Omicron Breakthrough Infection: A Prospective Nationwide Cohort Study in South Korea
Authors: Ahn Jin Young , Ko Jae-Hoon , Peck Kyong Ran , Bae Seongman , Kim Sung-Han , Lee Kyoung Hwa , Song Young Goo , Kim Yong Chan , Park Yoon Soo , Song Kyoung-Ho , Kim Eu Suk , Jeong Hye Won , Kim Shin-Woo , Kwon Ki Tae , Choi Won Suk , Choi Jun Yong 
Published: July 2023

Abstract

Background
Immune responses to each vaccine must be investigated to establish effective vaccination strategies for the ongoing coronavirus disease (COVID-19) pandemic. We investigated the long-term kinetics of immune responses after heterologous booster vaccination in relation to Omicron breakthrough infection (BI).

Methods
Our study included 373 healthcare workers who received primary ChAdOx1 vaccine doses and a third BNT162b2 vaccine dose. BIs that occurred after the third vaccine were investigated. Blood specimens were collected before and 3 months after the booster dose from participants without BI and 1, 4, and 6 months after BI from participants who experienced BI. Spike-specific binding and neutralizing antibody levels against the wild-type virus, Omicron BA.1, and Omicron BA.5, as well as cellular responses, were analyzed.

Results
A total of 346 participants (82 in the no BI group; 192 in the BI group during the BA.1/BA.2 period; 72 in the BI group during the BA.5 period) were included in the analysis. Participants without BI exhibited the highest binding and neutralizing antibody concentrations and greatest cellular response 1 month after the third vaccination, which reached a nadir by the ninth month. Antibody and cellular responses in participants who experienced BI substantially increased postinfection. Neutralizing antibody titers in individuals who experienced BI during the BA.1/BA.2 period showed more robust increase against wild-type virus than against BA.1 and BA.5.

Conclusions
Our findings provide evidence of antigenic imprinting in participants who received a heterologous booster vaccination, thereby serving as a foundation for further studies on the impact of BIs on immune responses.
Preferred nesting habitat of the slow-breeding Superb Lyrebird is rare and was disproportionately impacted by Australia’s “Black Summer” megafires (2019–2020) within a World Heritage Area
Authors: Hughes Eric J , Austin Victoria I , Backhouse Fiona , Maisey Alex C , Lopez Kelsie A , Mikles Chloe S , Odom Karan J , Welbergen Justin A , Dalziell Anastasia H 
Published: July 2023

Abstract
Understanding nest site selection is critical to developing effective conservation management actions. The Superb Lyrebird (Menura novaehollandiae) is one of many endemic species extensively impacted by Australia’s unprecedented 2019–2020 megafires. Over a period of 5 months, an estimated 43% of the entire range of this slow-breeding species was burnt, with the biggest impact on the central subspecies M. n. novaehollandiae (55%). Four months prior to these megafires, we conducted a field study of nest site habitat selection in the Superb Lyrebird within the Greater Blue Mountains World Heritage Area (15,400 km2): a key stronghold of the central subspecies of the Superb Lyrebird. We found that at the local scale, lyrebird nest sites were more likely to be found in habitats characterized by dense canopy trees and rich in rainforest elements such as vines and treeferns. At the landscape scale, lyrebird nests were most likely to be constructed in rainforest; this fire-sensitive habitat type made up only 1% of the Greater Blue Mountains World Heritage Area. The probability of nest occurrence also increased with slope. We also found that &gt;74% of all nesting habitat within the Greater Blue Mountains World Heritage Area burned in the 2019–2020 megafires, including 80% of areas of high suitability for nesting. These results suggest that the impact of these megafires on Superb Lyrebirds may be greater than currently thought. Given the importance of rainforest as nesting habitat for the ﻿Superb Lyrebird, managers should prioritize its restoration and protect it from future fire events. More broadly, our results illustrate how large-scale catastrophic events—such as megafires—can disproportionately affect habitats critical to specific points within an organism’s life cycle.
How Responsive Are Wages to Firm-Specific Changes in Labour Demand? Evidence from Idiosyncratic Export Demand Shocks
Authors: Garin Andrew , Silvério Filipe 
Published: July 2023

Abstract
Do firms adjust wages in response to changes in their own demand level or to changes in competitive pressure from rival employers? We study how exporters adjust wages in response to unexpected product demand shocks during the 2008–9 Great Recession. Using rich data on Portuguese firms’ pre-recession export shipments, we measure firm-level shocks to export demand during the Recession. We show that shocks constructed at the firm level are not necessarily firm-specific and can be decomposed into a common component affecting all producers in a product market and an idiosyncratic component affecting individual firms within markets based on the locations of their pre-recession customers. We demonstrate that while both components impact firms’ output and their workers’ wages, the common component spills over from firms to their labour market rivals, whereas the idiosyncratic component does not. We find that 10–15% of firms’ idiosyncratic demand passes through to their employees’ wage growth with no effect on retention rates, implying significant dependence of wages on noncompetitive quasi-rents. Moreover, we find that wages respond primarily to shifts in internal labour demand when labour markets are thin, but they respond more to competition from other employers when labour markets are fluid. These results indicate that employers’ ability to set wages hinges on the underlying competitiveness of the labour market.