bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenosine, Lidocaine and Magnesium (ALM) therapy modulates early sex-specific inflammatory and immune responses following experimental anterior cruciate ligament rupture and reconstruction
Authors: Morris Jodie L. , McEwen Peter C. , Letson Hayley L. , Dobson Geoffrey P. 
Published: July 2023

Abstract
Background
Early dysregulation of local and systemic inflammatory and immune responses is implicated in the pathogenesis of fibrotic and degenerative complications after anterior cruciate ligament reconstruction (ACLR) surgery. In other surgical trauma models, ALM therapy has been shown to blunt inflammation, leading to a more permissive healing environment in injured tissues. The purpose of this study was to evaluate sex-specific effects of surgery and perioperative ALM therapy on leukocyte mobilization and activation, and systemic and joint tissue inflammation in a rat model of ACL rupture and reconstruction.

Methods
Adult male and female Sprague–Dawley rats were randomly divided into ALM (male, n = 15; female, n = 14) or Saline control (male, n = 13; female, n = 14) treatment groups. Three days after non-invasive ACL rupture, ACLR surgery was performed on the injured knee. Animals received a 1 h perioperative IV ALM or saline drip, and a 0.1 ml IA bolus of ALM or saline, and were monitored to 120 h postoperative. Hematology, leukocyte immunophenotyping, plasma and synovial inflammatory mediator concentrations, and joint tissue histopathology and gene expression of inflammatory markers were assessed.

Results
Following ACLR surgery, plasma concentrations of inflammatory cytokines IL-6, TNF-α and IL-1β peaked later and at a higher magnitude in females compared to males, with ALM dampening this systemic inflammatory response. At 1 h postoperative, ALM boosted circulating B cell numbers in males and females, and decreased neutrophil activation in females. By 72 h, numbers of circulating T cells with immunoregulatory potential were increased in all ALM-treated animals compared to Saline controls, and corresponded to a significant reduction in synovial TNF-α concentrations within the operated knees. Sex-specific treatment differences were found in inflammatory and immune profiles in the synovial fluid and joint tissues. Inflammatory cell infiltration and gene expression of markers of inflammation (Nfκb, Nlrp3), cytoprotective responses (Nrf2), and angiogenesis (Vegf) were increased in joint synovial tissue from ALM-treated males, compared to controls. In females, ALM treatment was associated with increased mononuclear cell recruitment, and expression of M2 macrophage marker (Arg1) in joint synovial tissue.

Conclusions
ALM has differential effects on the immuno-inflammatory response of males and females in the early postoperative period after ACLR surgery, with potential implications for subsequent joint tissue repair processes.
Gene polymorphism of FTO rs8050136 and CDKAL1 rs10946398 and their association with type 2 diabetes mellitus in the Egyptian patients
Authors: Ragab Halla M. , El Maksoud Nabila Abd , Amin Mona A. , Elaziz Wafaa Abd 
Published: July 2023

Abstract
Background
An extensive quest for genetic variables impacting the susceptibility for type 2 diabetes mellitus (T2DM) and other cardiometabolic disorders has been sparked by the global growth in the frequency of those widespread ailments. Although the association between several SNPs and T2DM has been reported in prior research, little is known about the association between SNPs FTO rs8050136, and CDKAL1 rs10946398 and T2DM in Egyptian population. This study aims to investigate these two identified SNPs in Egyptian diabetic patients to ascertain their underlying genetic influences on T2DM. This study included 50 diabetic patients and 50 healthy subjects. Each individual underwent a clinical assessment and total body examination, laboratory investigations including liver enzymes, fasting blood sugar, glycated hemoglobin (HbA1C), and lipid profile. The DNA Purification Kit was used to separate genomic DNA from the whole blood. Gene polymorphism was detected via PCR-REFLP and PCR-AS methods.

Results
There was a significant association between the presence of the C allele in the FTO gene at rs8050136 and T2DM among studied people. The patient group had a considerably higher frequency of the FTO "AC" genotype and the "C" allele (P < 0.05). Additionally, only the wild-type homozygous “GG” of the CDKAL1 rs10946398 was found in all the studied cases.

Conclusions
The FTO "CC" genotype is significantly associated with T2DM in the Egyptian population. However, no association was detected between CDKAL1 rs10946398 and T2DM. This result may be attributed to the small sample size or the rare incidence of this SNP in the Egyptian population. The study suggests verifying the findings on a larger sample and looking into the relationship between T2DM and additional gene polymorphisms.
Isolation and evaluation of erythroid progenitors in the livers of larval, froglet, and adult Xenopus tropicalis
Authors: Omata Kazuki , Nomura Ikki , Hirata Akito , Yonezuka Yuka , Muto Hiroshi , Kuriki Ryo , Jimbo Kirin , Ogasa Koujin , Kato Takashi 
Published: July 2023

ABSTRACT
Xenopus liver maintains erythropoietic activity from the larval to the adult stage. During metamorphosis, thyroid hormone mediates apoptosis of larval-type erythroid progenitors and proliferation of adult-type erythroid progenitors, and a globin switch occurs during this time. In addition, the whole-body mass and the liver also change; however, whether there is a change in the absolute number of erythroid progenitors is unclear. To isolate and evaluate erythroid progenitors in the Xenopus liver, we developed monoclonal ER9 antibodies against the erythropoietin receptor (EPOR) of Xenopus. ER9 recognized erythrocytes, but not white blood cells or thrombocytes. The specificity of ER9 for EPOR manifested as its inhibitory effect on the proliferation of a Xenopus EPOR-expressing cell line. Furthermore, ER9 recognition was consistent with epor gene expression. ER9 staining with Acridine orange (AO) allowed erythrocyte fractionation through fluorescence-activated cell sorting. The ER9+ and AO-red (AOr)high fractions were highly enriched in erythroid progenitors and primarily localized to the liver. The method developed using ER9 and AO was also applied to larvae and froglets with different progenitor populations from adult frogs. The liver to body weight and the number of ER9+ AOrhigh cells per unit body weight were significantly higher in adults than in larvae and froglets, and the number of ER9+ AOrhigh cells per unit liver weight was the highest in froglets. Collectively, our results show increased erythropoiesis in the froglet liver and demonstrate growth-dependent changes in erythropoiesis patterns in specific organs of Xenopus.
CRIAÇÃO LITERÁRIA
Authors: Das Virgens Aldo , Aureo Augusto  , Borges Crisanto , Rodrigues Henrique , Figueiredo Herivelton , Hermes José , D'Eça Manoel , Carneiro Miguel , Lopes Raymundo Luiz 
Published: July 2023

Tritura um pedregulho de rimase engole a fábulada indigestãonasce o verso
Godofredo Filho
APLICAÇÃO DA METODOLOGIA SISTÊMICA AO ESTUDO DO SÍTIO URBANO DE FEIRA DE SANTANA - BA
Authors: Pacheco de Almeida José Antonio 
Published: July 2023

A pesquisa foi desenvolvida com base na teoria geossistêmica, considerando o geossistema como uma unidade de paisagem complexa, onde interagem elementos bióticos, abióticos e antrópicos. Dessa forma, o presente trabalho procurou, com base na compartimentação geomorfológica da área de estudo, definir os vários aspectos naturais da paisagem, identificar os conflitos ecológicos impactantes decorrentes do uso e ocupação do solo urbano, bem como, suas inter-relações e conseqüências sobre a dinâmica natural.
discours éthiques de la mode : Entre réparation et renouveau des modèles
Authors: Ambrosio Alberto Fabio 
Published: July 2023

La mode est en train de se « convertir » – et pour cause : ce n’est pas un hasard en temps d’urgence – à une éthique écologique. Le thème choisi pour cette contribution est dicté par l’intention d’explorer le langage qu’utilise la mode éthique dans un corpus de textes de nature diverse ayant tous pour trame de fond un vocabulaire dont les connotations renvoient à un lexique de philosophie religieuse. L’hypothèse sous-jacente à cette recherche est qu’une partie de cet outillage discursif peut être intimement reliée à un discours moral, voire résolument spirituel. De la « conversion » écologique de la mode à la préconisation de pratiques quasi ascétiques devant déboucher sur un comportement plus responsable de consommateur non compulsif en passant par le pacte de la mode et tout le discours tournant autour de la deuxième vie à donner aux vêtements, le langage utilisé semble parsemé d’emprunts au corpus de la théologie. Voilà qui conférerait à la mode, déjà éthique par nature, la possibilité de se hisser au rang d’un modèle moral dont la compétence s’élargirait jusqu’à devenir nouvelle orthodoxie ou nouvelle orthopraxie. L’idée d’où est sortie La Contre-mode, de Monsieur de Fitelieu, texte de 1642, trouve des correspondances contemporaines dans le manifeste anti-mode de Lidewij Edelkoort, aussi bien que dans un nouveau discours prônant une consommation vestimentaire capable de prendre en compte la protection de la planète. Ainsi la mode serait au confluent de deux modèles : celui du discours éthique renouvelé et, parallèlement, un élément récurrent du cycle historique, s’il faut en croire Giambattista Vico (m. 1744), philosophe de l’histoire, qui, dans Corsi e ricorsi oppose à la mode et à son discours une autre mode et ses pratiques.
Remote HbA1c testing via microsampling: fit for purpose?
Authors: Verougstraete Nick , Stove Veronique , Stove Christophe P. 
Published: July 2023

Abstract
The collection of capillary blood microsamples via finger-prick has several advantages over traditional blood collection. It is considered convenient and more patient-centric, enabling collection of the sample by the patient at her/his home with subsequent analysis in the lab following postal shipment. Determination of the diabetes biomarker HbA1c in self-collected microsamples to remotely monitor diabetes patients seems to be a very promising option which could eventually lead to better treatment adaptations and disease control. This is especially convenient/relevant for patients living in areas where venipuncture is impractical, or to support virtual consultations using telemedicine. Over the years, a substantial numbers of reports on HbA1c and microsampling have been published. However, the heterogeneity of the applied study designs and data evaluation is remarkable. This review provides a general and critical overview of these papers, along with specific points of attention that should be dealt with when aiming at implementing microsampling for reliable HbA1c determination. We focus on the used (dried) blood microsampling techniques, collection conditions, stability of the microsamples, sample extraction, analytical methods, method validation, correlation studies with conventional venous blood samples and patient satisfaction. Lastly, the possibility of using liquid instead of dried blood microsamples is discussed. Liquid blood microsampling is expected to have similar advantages as dried blood microsampling and several studies suggest it to be a suitable approach to collect samples remotely for subsequent HbA1c analysis in the lab.
Tensile properties of sandwich-designed carbon fiber filled PLA prepared via multi-material additive layered manufacturing and post-annealing treatment
Authors: Wang Zhaogui , Yin Xiuzeng , Wang Lihan 
Published: July 2023

Abstract
Polylactic Acid (PLA) experiences widely spread applications in Fused Filament Fabrication (FFF) owing to its relatively high stiffness, strength, and environmentally friendly biodegradability. Reinforcing inclusions like short carbon fibers are introduced to virgin PLA feedstock aiming to improve the mechanical performance of FFF-made products. Nevertheless, the rigid fibers significantly reduce the ductility of the overall fabricated parts. This study prepares sandwich specimens with PLA as core and its 10 wt% chopped carbon fiber reinforced composites (i.e., CF/PLA) as shell via a low-cost FFF-based multi-material additive layered manufacturing method. The sandwich specimen has three layers, which are changed according to different material volumes, which is able to design the local strength and toughness performances of a printed part. Tensile properties of these sandwich samples printed in the different volumetric rates of virgin PLA constituents are measured. It is found that the strength of sandwich specimens with 20% vol of PLA reduces noticeably as compared to the full CF/PLA specimens. The 80% vol specimens exhibit a competitive strength as compared to the 40% and 60% vol specimens, while its toughness increases notably as compared to the other cases. Finite element simulations of the layered manufacturing process show that the thermal residual stresses of 20% vol sandwich accumulates most significantly. We also explore the effects of thermal annealing on the prepared sandwiches. Experimental results indicated that the post-annealing process improved the strength and stiffness of the sandwich specimens, while enhancing the stability of the mechanical properties of the FFF printed sandwich.
Revisiting Dependency and Development in the Age of Globalization
Authors: Özekin Muhammed Kürşad 
Published: July 2023

Abstract
Does dependency theory no longer offer an analytical and conceptual framework for the study of underdevelopment under the dynamics of modern globalization and the new international division of labor? Has the emergence of newly industrialized countries and a rising proportion of higher value-added manufacturing in the Global South cast the notions of subordination, peripherality, and dependence into the dustbin of history? These questions are today answered affirmatively by a broad consensus. In contrast to this widely-held assertion in the current development discourse, this study aims to bring these notions back to critical development studies by offering an up-to-date and analytically valid theorization of dependency in today’s Global South. Taking the historical-structural dependency perspective as a point of departure, the study revisits the notion of dependent development by drawing on a set of conceptual insights derived from Schumpeter’s theory of innovation, Global Value Chain analyses, and a class-relational articulation of the developmental state. In doing so, the study shows how core and periphery activities have clustered in time and space, leading to polarization in today’s global economy, and how new forms of dependency have been spatially reproduced along hierarchically-structured global value chains through the interplay of transnational corporations, states, and classes.
A review of neuroimaging-based data-driven approach for Alzheimer’s disease heterogeneity analysis
Authors: Liu Lingyu , Sun Shen , Kang Wenjie , Wu Shuicai , Lin Lan 
Published: July 2023

Abstract
Alzheimer’s disease (AD) is a complex form of dementia and due to its high phenotypic variability, its diagnosis and monitoring can be quite challenging. Biomarkers play a crucial role in AD diagnosis and monitoring, but interpreting these biomarkers can be problematic due to their spatial and temporal heterogeneity. Therefore, researchers are increasingly turning to imaging-based biomarkers that employ data-driven computational approaches to examine the heterogeneity of AD. In this comprehensive review article, we aim to provide health professionals with a comprehensive view of past applications of data-driven computational approaches in studying AD heterogeneity and planning future research directions. We first define and offer basic insights into different categories of heterogeneity analysis, including spatial heterogeneity, temporal heterogeneity, and spatial-temporal heterogeneity. Then, we scrutinize 22 articles relating to spatial heterogeneity, 14 articles relating to temporal heterogeneity, and five articles relating to spatial-temporal heterogeneity, highlighting the strengths and limitations of these strategies. Furthermore, we discuss the importance of understanding spatial heterogeneity in AD subtypes and their clinical manifestations, biomarkers for abnormal orderings and AD stages, the recent advancements in spatial-temporal heterogeneity analysis for AD, and the emerging role of omics data integration in advancing personalized diagnosis and treatment for AD patients. By emphasizing the significance of understanding AD heterogeneity, we hope to stimulate further research in this field to facilitate the development of personalized interventions for AD patients.
REPRESENTAÇÃO DAS MULHERES NOS LIVROS DIDÁTICOS DO PNLD CAMPO E SUAS POSSIBILIDADES
Authors: Santos Maria Luíza Lucas dos , Maldonado Maritza Maciel Castrillon , Peripolli Odimar João 
Published: July 2023

No Brasil os livros didáticos são os principais artefatos utilizados pelos professores da rede pública no processo de ensino e aprendizagem, contribuindo, consubstancialmente, na constituição de sujeitos de determinados tipos. Com base nessa constatação, percebemos a necessidade de problematizar como estes materiais representam homens e mulheres em seus enunciados e ilustrações. Para isso, escolhemos como objeto de pesquisa a coleção de livros didáticos “Novo Girassol: saberes e fazeres do campo”, do Programa Nacional do Livro Didático e do Material Didático (PNLD) Campo, utilizando como método de análise ferramentas arqueo-genealógicas. Como resultado, percebemos que as mulheres ainda possuem menos espaços de representação do que os homens nos livros didáticos, e que muitas vezes os papéis reforçam estereótipos de gênero, de raça e de classe. Porém, acreditamos na força desses artefatos, enquanto rizomas, que podem produzir efeitos outros nos corpos que os utilizam, desde que outras histórias sejam contadas, outras imagens sejam veiculadas. Ao final sugerimos que histórias de mulheres brasileiras, que se destacam sócio-cultural-artisticamente, sejam adicionadas às coleções de livros didáticos pertencentes ao PNLD e que encontrem igualdade de oportunidade para demonstrar seus feitos.
REFLEXÕES SOBRE RELAÇÕES ÉTNICO-RACIAIS
Authors: Bruxel Carla Maria Leidemer , Bianchi Vidica , Boff Eva Teresinha de Oliveira 
Published: July 2023

A educação antirracista combate todas as formas de expressão de racismo e busca promover o respeito e a valorização das diferentes culturas e identidades dos povos. A Lei Federal 10.639/2003, modificada pela Lei 11.645/2008, estabelece a inclusão da história e a cultura afro-brasileira e indígena como temáticas obrigatórias, e contribui na valorização da cultura e da história negra e indígena. Este artigo objetiva refletir sobre as relações étnico-raciais para o desenvolvimento de um currículo escolar voltado à educação antirracista, por meio da análise de artigos, apresentados em um dossiê temático de um periódico nacional, que tratam de práticas e reflexões envolvendo as relações étnico-raciais. Usou-se como metodologia a pesquisa bibliográfica, com abordagem qualitativa. Os dados demonstram que as reflexões e práticas pedagógicas desenvolvidas em relação às questões étnico-raciais contribuem na valorização da história, da cultura e da identidade racial. Assim, a educação antirracista, que incorpora as relações étnico-raciais, deve estar contemplada no currículo escolar e ser desenvolvida nas práticas pedagógicas para combater a discriminação racial e promover a valorização da identidade negra e indígena.
EU SOU PRETA, MINHA BOCA É MARROM... SOU IGUAL Á PRETINHA DA HISTÓRIA!
Authors: Oliveira Joana Paula dos Santos Gomes de , Esteban Maria Teresa 
Published: July 2023

O artigo traz reflexões sobre a produção, no cotidiano da educação infantil, de práticas pedagógicas articuladas à pedagogia antirracista. Sua referência está em uma pesquisa qualitativa, com o cotidiano escolar, envolvendo a experiência de uma de suas autoras, em seu processo de formação como professora pesquisadora, exercendo a docência numa instituição de educação infantil, vinculada a uma rede pública municipal. O artigo se desenha a partir da memória da professora e alguns de seus registros do vivido, especialmente com uma criança negra deste grupo, ao propor-se a articular literatura infantil e encontro com a negritude. O desenvolvimento da pesquisa percorre o racismo, como produção social que alimenta a desigualdade e fere as crianças e suas infâncias; sua problematização, como aspecto relevante da educação infantil; e seu enfrentamento, como processo que conduz ao exercício da pedagogia antirracista, imperioso no movimento de produção da educação libertadora. Suas conclusões ressaltam a potência da literatura infantil para mobilizar reflexão, diálogo e encontro com a negritude como afirmação do direito à diferença.
TEORIA CURRICULAR E POLÍTICA CURRICULAR
Authors: Ramos Jéssica Rochelly Da Silva , Cunha Kátia Silva , Santos Leonardo da Silva 
Published: July 2023

O artigo focaliza o debate sobre a teoria curricular e a política curricular nas atuais reformas e políticas educacionais, argumentando que tais políticas intentam sobre o controle do outro e na tentativa de dar uma resposta ao que é lido como conhecimento “faltoso” busca definir conhecimentos centralizados, excluindo as diferenças das políticas e dos currículos. A partir de um estudo e de revisão teórica, discutimos à luz da Teoria do Discurso e das contribuições do pensamento de Derrida, os processos contingentes de subjetivação das políticas, a tradução que impede o controle do conhecimento, dos currículos, da formação, da decisão e do sujeito. Concluímos, provisoriamente que, o conflito em torno do pensamento curricular e das teorias, bem como a disputa pelo poder de decidir o que deve ser ensinado e aprendido, tem marcado a tentativa de fixar nas políticas e nos currículos para a escola do campo projetos de formação que tentam controlar a formação desses povos e produzir sujeitos universais, desconsiderando os processos de diferir e as diferenças. Nesse sentido, defendemos a ideia de teoria e de política comprometida e marcada pelo comprometimento ético-político com a alteridade e com a desconstrução. Apostamos em uma teoria e política negociada e produzida nas ambivalências e contingências provocadas pelos processos de diferir, comprometidas com a alteridade na desconstrução de normatividades, da BNCC.
EDUCACIÓN SEXUAL INTEGRAL EN TIEMPOS DE PANDEMIA:
Authors: Baez Jesica , Fainsod Paula 
Published: July 2023

En este artículo reflexionamos acerca de tres experiencias pedagógicas que acontecieron durante el 2020-2021 tejidas durante la pandemia de Covid-19 que acompañamos como coordinadoras de las mismas. Estas propuestas surgieron en alianza entre universidad y estados provinciales, tuvieron como horizonte ampliar la implementación de la educación sexual integral como política educativa y se orientaron a estrategias de capacitación hacia actores centrales de la comunidad educativa. Estos cursos emergen en el marco de la virtualización forzada en las instituciones educativas dadas por la no presencialidad, en un contexto atravesado por la profundización y particularización de las desigualdades de género que la pandemia mostró y se inscribieron en un trama social disputada por grupos antiderechos. Nos interesa describir y analizar el itinerario de cada uno de estos cursos advirtiendo las lecciones aprendidas en torno a dos dimensiones. Por un lado, dando cuenta de cómo la educación sexual integral es una herramienta que permite hacer “texto el contexto” y por otra parte, analizando el lugar de la virtualidad destacando sus potencialidades y limitaciones. Para ello recuperaremos notas del proceso, registros de la experiencias, foros realizados en los campus, entre otros.