bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitrogen Atom Induced Contrast Effect on the Mechanofluorochromic Characteristics of Anthracene‐Based Acceptor‐Donor‐Acceptor Fluorescent Molecules
Authors: Yu Hao , Tian Peiyuan , Han Ningxu , Li Meng , Wang Ming 
Published: September 2023

AbstractThe mechanofluorochromic (MFC) characteristics of anthracene‐based acceptor‐donor‐acceptor (A−D−A) fluorescent molecules are explored through a comprehensive investigation of their photophysical behaviors. Six 9,10‐diheteroarylanthracene derivatives with varying acceptor groups (pyridin‐4‐yl, pyridin‐3‐yl, pyridin‐2‐yl, pyrimidin‐5‐yl, pyrazinyl and quinoxalinyl) are synthesized and systematically characterized. The photophysical properties in both solution and solid‐state are examined, revealing subtle yet significant influences of the spatial arrangement and number of nitrogen atoms within the acceptor group on fluorescence emission. Single‐crystal structures of these compounds provide insights into their steric configurations and intermolecular packing modes, offering valuable insights into the fundamental mechanisms that underlie the observed MFC properties. This study illuminates the intricate interplay between MFC properties and the refined molecular structure, thus presenting promising avenues for the design and advancement of novel MFC materials.
The anti‐inflammatory effects of mesenchymal stem cells attenuate diffuse pulmonary hemorrhage
Authors: Guan Yajin , Chen Qianqing , Xu Jiahuan , Chen Boyu , Ou Baofang , Liu Tianping , Xie Shuilin , Bie Yanan 
Published: September 2023

AbstractThere are few effective treatment options for diffuse pulmonary hemorrhage (DPH). We aimed to elucidate the therapeutic role and underlying mechanisms of mesenchymal stem cells (MSCs) and MSC‐derived extracellular vesicles (MSC‐EVs) in DPH. Therapeutic effects of MSCs/MSC‐EVs in pristane‐induced DPH mice were evaluated via pulmonary function testing and histopathology. Transcriptome sequencing analyzed differentially expressed genes in control, DPH, and MSC groups. The proportion of macrophage polarization was evaluated in vivo and in vitro via fluorescence‐activated cell sorting in control, DPH, MSC, MSC‐EV inhalation, and MSC‐EV intravenous groups. Intraperitoneal injection of pristane induced diffuse alveolar hemorrhage, early fibrosis, and inflammation in C57BL/6 mice. Monocytes were depleted in the peripheral blood in DPH mice and MSCs were recruited to the lungs, resulting in significantly attenuated diffuse alveolar hemorrhage and suppressed immunological response. This was more effective in the hyperacute hemorrhage phase than the early inflammatory phase. An MSC treatment‐mediated anti‐inflammatory effect was observed in DPH mice. Furthermore, MSC‐EVs inhalation or tail‐vein injection could effectively reduce DPH injury. MSCs could suppress macrophage M1 polarization in DPH in vivo and in vitro. MSCs displayed significant therapeutic effects in pristane‐induced DPH, which may be a promising cell‐free therapeutic approach.
Resting parasympathetic activity is associated with malodor‐induced change in perceived foreignness of speakers
Authors: Faig Kelly E. , Necka Elizabeth A. , Smith Karen E. , Dimitroff Stephanie J. , Norman Greg J. 
Published: September 2023

AbstractIntroductionTo protect against infection, individuals have evolved context‐dependent pathogen‐avoidant strategies, including selective social behaviors aimed at avoiding foreign individuals who may possess greater risk of infection. Parasympathetic nervous system (PNS) activity is associated with social engagement and regulation of the classical immune system but has not been widely investigated in relation to changes in intergroup perception and the behavioral immune system.MethodThe current research investigated the relationship between parasympathetic activity and perceived foreignness of in and outgroup speakers during exposure to a pathogen‐relevant odor (butyric acid). High‐frequency heart rate variability was measured at rest and while participants rated foreignness of speakers with and without the odor present.ResultsFindings show that exposure to the odor was associated with higher foreignness perceptions of outgroup speakers and lower foreignness perceptions of ingroup speakers. This effect was especially evident among individuals with higher resting parasympathetic activity.ConclusionThese results suggest that the PNS may play a role in changes in social perceptions during a behavioral immune response.
Impact of proton pump inhibitors on the onset of gastrointestinal immune‐related adverse events during immunotherapy
Authors: Lasagna Angioletta , Mascaro Federica , Figini Simone , Basile Sara , Gambini Giulia , Klersy Catherine , Lenti Marco Vincenzo , Di Sabatino Antonio , Di Benedetto Alice , Calvi Monica , Bruno Raffaele , Sacchi Paolo , Pedrazzoli Paolo 
Published: September 2023

AbstractIntroductionThe gut microbiota (GM) can influence the pathogenesis of immune‐mediated adverse events (irAEs). Proton pump inhibitors (PPIs) can affect the integrity of GM, but their role in promoting irAEs is still poorly understood.MethodsIn this retrospective single‐center cohort study, the primary endpoint was the evaluation of the incidence of gastrointestinal (GI) irAEs in cancer patients on PPIs (exposed) versus cancer patients who were not on PPIs (unexposed).ResultsThree hundred and sixty three patients' records (248 M/115F, median age 69) were reviewed. Twenty‐three exposed patients (92%) developed GI irAEs while only two unexposed patients (8%) developed GI irAEs (hazard ratio [HR] 13.22, 95% confidence interval [CI] 3.11–56.10, p < 0.000). This HR was confirmed after weighting for the propensity score (HR15.13 95% CI 3.22–71.03, p < 0.000).ConclusionChronic PPI use is associated with an increased risk of GI irAES.
Regional disparities in suicide among patients with cancer: A nationwide population‐based study in Japan
Authors: Kurisu Ken , Harashima Saki , Fujimori Maiko , Akechi Tatsuo , Yoshiuchi Kazuhiro , Uchitomi Yosuke 
Published: September 2023

AbstractBackgroundThis study aimed to explore prefecture‐level differences in suicide risk among patients with cancer in Japan.MethodsData from the National Cancer Registry, which covers the entire Japanese population, were used. Patients diagnosed with cancer between 2016 and 2017 were included. The standardized mortality ratio (SMR) for suicide within 2 years after cancer diagnosis was quantified compared with the general population for each prefecture. Multivariate Poisson regression analysis was conducted to quantify the adjusted relative risk using Hokkaido as the reference.ResultsThe analysis included 2,133,502 patients. The SMRs were high among patients with cancer residing in certain prefectures, such as the Hokuriku region (the middle and western parts of Japan's main island). These areas also exhibited a significant relative risk in the Poisson regression model.ConclusionThe results demonstrated that patients with cancer in certain prefectures in Japan have a high suicide risk.
Comparison of data from six psychotherapy research measures obtained through MTurk versus traditional clinics
Authors: Russell Kelley A. , Swift Joshua K. , Bingham Jacob 
Published: September 2023

AbstractObjectiveAlthough researchers have begun to use MTurk for psychotherapy‐related studies, little is known about the quality of psychotherapy research data that can be obtained through this platform. The fourfold purpose of this study was to (1) compare data collection times between clients recruited through MTurk and those recruited through traditional clinic sources, (2) test for differences in demographic and treatment use variables between these two samples, (3) examine whether psychotherapy research data gathered through these different strategies shows comparable properties and (4) test whether recruitment decisions within MTurk can impact the quality of the data obtained.MethodClients (828 recruited through MTurk and 62 recruited through outpatient clinics) completed an online survey that included treatment history questions and six measures that are frequently used in psychotherapy research.ResultsHighly similar demographics, treatment history and properties for the measures (i.e., means, standard deviations, internal consistency, factor structure and convergent validity) were found between the samples. For the most part, the quality of the MTurk data did not differ depending on the compensation amount or participant restrictions.ConclusionThese results suggest that MTurk can be a quick, reliable and valid resource for participant recruitment when conducting some types of psychotherapy research.
Original synthesis of polyvinyl butyral with a green deep eutectic solvent and a weakly polyacrylic acid from polyvinyl alcohol and the impacts of the chains structures of polyvinyl alcohol
Authors: Zhang Yumeng , Lv Xiaolu , Chen Hongjun , Zhang Ziyang , Li Fengtao , Zeng Zuoxiang , He Xuelian 
Published: September 2023

AbstractIn this work, an environmentally‐friendly deep eutectic solvent (DES) was employed as a catalyst to generate polyvinyl butyral (PVB) resins from polyvinyl alcohol (PVA) with a weakly acidic polymer (polyacrylic acid [PAA]) as an emulsifier. Finally, high viscosity PVB resins with molecular weight of 110,000–200,000 g · mol−1 and acetalization degree above 83% were successfully synthesized, which was found to satisfy the requirements for interlayer films between safety glass. Furthermore, it was well proved that the properties of PVB resins immensely depend on the molecular structures of the PVA. The molecular weight of the PVB, independent of alcoholic degrees of the PVA, indicated an upward trend with the increase of the molecular weight of the PVA. As for these four PVBs with high molecular weight, the Tg was sensitive to the content of hydroxyl and acetal groups rather than molecular weight, associated with the inter‐ or intra‐molecule hydrogen bond between OH. PVB‐1799 and PVB‐1797 had higher Ti and Tg than that of PVB‐1788 and PVB‐1795 because the former had low contents of vinyl acetate group (VAc) and alcohol hydroxyl group (VOH). The tensile strength of PVBs was all higher than 30 Mpa, and the elongation at break was about 300% due to their high molecular weights.
Who is CSR for in employer branding? Insights on employer branding strategies across industries, educational backgrounds and career styles
Authors: Buzzao Giacomo , Rizzi Francesco 
Published: September 2023

AbstractSince recruiting high‐potential employees is essential to be innovative and sustainable, scholars and practitioners advocate using attributes of general interest for employer branding. Through two empirical studies, this research investigates to what extent employer branding strategies can rely only on sustainability‐related attributes to win the war for talent. Study 1 compares the effects of (corporate social responsibility) CSR and other sustainability‐related symbolic attributes (namely originality and resilience) on applicants across different educational backgrounds. The results reveal that the applicants' attitudes towards these attributes vary across their social identities, especially concerning the search for employer originality, which is a proxy of organisational innovativeness. Study 2 focuses on how personal identities shape the reactions to different career growth opportunities. The experiment on engineering graduates reveals that those applicants aiming to advance their career faster (boundaryless) find advancement opportunities based on self‐initiative more attractive than those based on organisational support, which further contrasts the belief that CSR‐related attributes are universally effective. Results contribute to the employer branding theory by demonstrating that applicants' social and personal identities determine the effectiveness of CSR and other, previously unexplored, symbolic and instrumental employer attributes. They also provide employers with directions for designing effective recruiting strategies across educational backgrounds and career preferences.
Multi‐Functional Organofluoride Catalysts for Polyesters Production and Upcycling Degradation
Authors: Zhang Qiao , Hu Chenyang , Pang Xuan , Chen Xuesi 
Published: September 2023

AbstractThe production and degradation of polyesters are two crucial processes in polyester materials’ life cycle. In this work, multi‐functional organocatalysts based on fluorides for both processes are described. Organofluorides were developed as catalysts for ring‐opening polymerization of lactide (lactone). Compared with a series of organohalides, organofluoride performed the best catalytic reactivity because of the hydrogen bond interaction between F− and alcohol initiator. The Mn values of polyester products could be up to 72 kg mol−1. With organofluoride catalysts, the ring‐opening copolymerization between various anhydrides and epoxides could be established. Furthermore, terpolymerization of anhydride, epoxide, and lactide could be constructed by the self‐switchable organofluoride catalyst to yield a block polymer with a strictly controlled polymerization sequence. Organofluorides were also efficient catalysts for upcycling polyester plastic wastes via alcoholysis. Mixed polyester materials could also be hierarchically recycled.
Application of an Oscillatory Plug Flow Reactor to Enable Scalable and Fast Reactions in Water Using a Biomass‐Based Polymeric Additive**
Authors: Hammer Susanne , Nanto Filippo , Canu Paolo , Ötvös Sándor B. , Kappe C. Oliver 
Published: September 2023

AbstractThe utilization of water as a sustainable reaction medium has important advantages over traditional organic solvents. Hydroxypropyl methylcellulose has emerged as a biomass‐based polymeric additive that enables organic reactions in water through hydrophobic effects. However, such conditions imply slurries as reaction mixtures, where the efficacy of mass transfer and mixing decreases with increasing vessel size. In order to circumvent this limitation and establish an effectively scalable platform for performing hydroxypropyl methylcellulose‐mediated aqueous transformations, we utilized oscillatory plug flow reactors that feature a smart dimensioning design principle across different scales. Using nucleophilic aromatic substitutions as valuable model reactions, rapid parameter optimization was performed first in a small‐scale instrument having an internal channel volume of 5 mL. The optimal conditions were then directly transferred to a 15 mL reactor, achieving a three‐fold scale‐up without re‐optimizing any reaction parameters. By precisely fine‐tuning the oscillation parameters, the system achieved optimal homogeneous suspension of solids, preventing settling of particles and clogging of process channels. Ultimately, this resulted in a robust and scalable platform for performing multiphasic reactions under aqueous conditions.
Neurobehavioral alterations induced by third‐trimester gestation‐equivalent ethanol exposure are inhibited by folate administration
Authors: Marengo Leonardo , Barey Agostina , Salguero Agustín , Fabio María C. , Cendán Cruz Miguel , Morón‐Henche Ignacio , D'Addario Claudio , Pautassi Ricardo Marcos 
Published: September 2023

AbstractPrenatal ethanol exposure (PEE) causes several neurobehavioral impairments in the fetus. Postnatal days (PDs) 4–9 in rodents are considered equivalent to the third trimester of gestation in humans. This period is characterized by high rates of synaptogenesis and myelination and the maturation of key structures and transmitter systems. Nutritional supplements, such as folate, have gained attention as putative treatments to mitigate detrimental effects of PEE. Folate is crucial for DNA synthesis and amino acid metabolism and heightens antioxidant defenses. The present study examined neurobehavioral effects of the concurrent administration of folate (20 mg/kg/day) and ethanol (5 g/kg/day) during PDs 4–9 in male and female Wistar rats. During PDs 16–18, the rat pups were tested for anxiety‐like and exploratory activity in the light–dark box (LDB), open field (OF), and concentric square field (CSF) tests. After weaning, they were tested for sucrose preference and ethanol intake. Neonatal ethanol exposure reduced body weight in infancy but did not enhance ethanol self‐administration or significantly affect performance in the OF or LDB. Neonatal ethanol exposure also reduced sucrose intake in the preference test and increased shelter‐seeking in the CSF, and folate significantly inhibited these effects. The present findings suggest that folate, a treatment that is devoid of serious side effects, can ameliorate some neurobehavioral effects of PEE.
Determination of urinary deanol‐N‐oxide excretion profiles after ingestion of nutritional supplements containing deanol
Authors: Krug Oliver , Guddat Sven , Görgens Christian , Piper Thomas , Möller Tristan , Thevis Mario 
Published: September 2023

Abstract2‐(Dimethylamino)ethan‐1‐ol (Deanol) is a widely produced chemical used by both industry and consumers in a variety of applications. Meclofenoxate, a stimulant classified on the World Anti‐Doping Agency Prohibited List, metabolizes into deanol and, presumably, its main metabolite deanol‐N‐oxide. Hence, using liquid chromatography–tandem mass spectrometry, a quantitative detection method for deanol‐N‐oxide in urine was developed. Subsequently, the urinary excretion of deanol‐N‐oxide after oral application of 130 mg of deanol was determined in six volunteers, and urine samples of a cohort of 180 male and female athletes from different sports were analyzed. In addition, urinary deanol‐N‐oxide was determined in an exploratory study with one volunteer ingesting 250 mg of meclofenoxate. The developed test method allowed for limits of detection and quantification for deanol‐N‐oxide at 0.05 and 0.15 μg/mL, respectively. Urinary deanol‐N‐oxide cmax levels were found between 100 and 250 μg/mL 2–5 h post‐administration of 130 mg of deanol. Similarly, urine samples collected after the administration of 250 mg of meclofenoxate exhibited cmax levels of 115 μg/mL. In contrast, deanol‐N‐oxide urine concentrations of pre‐administration specimens and 180 routine doping control urine sample were between 0.3 and 1.3 μg/mL and below limit of quantification and 1.8 μg/mL, respectively. The study suggests that the use of deanol and meclofenoxate results in significantly elevated urinary deanol‐N‐oxide levels. Whether or not monitoring deanol‐N‐oxide in doping controls can support decision‐making processes concerning the detection of meclofenoxate use necessitates further investigations taking into consideration the elimination kinetics of 4‐chlorophenoxyacetic acid, the main metabolite of meclofenoxate, and deanol‐N‐oxide.
Methiothepin downregulates SNAP‐23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow‐derived mast cells
Authors: Kondo Daisuke , Suzuki Ruriko , Matsumura Ayako , Meguri Hitomi , Tanaka Masahiko , Itakura Makoto , Hirashima Naohide 
Published: September 2023

AbstractIn the present study, we found that methiothepin (a nonselective 5‐hydroxytryptamine [5‐HT] receptor antagonist) inhibited antigen‐induced degranulation in rat basophilic leukemia cells and mouse bone marrow‐derived mast cells. Although antigen stimulation induces release of histamine and serotonin (5‐HT) by exocytosis and mast cells express several types of 5‐HT receptor, the detailed role of these receptors remains unclear. Here, pretreatment of cells with methiothepin attenuated increased intracellular Ca2+ concentration, phosphorylated critical upstream signaling components (Src family tyrosine kinases, Syk, and PLCγ1), and suppressed TNF‐α secretion via inhibition of Akt (a Ser/Thr kinase activated by PI3K)and ERK phosphorylation. Furthermore, it inhibited PMA/ionomycin‐induced degranulation; this finding suggested that methiothepin affected downstream signaling. IκB kinase β phosphorylates synaptosomal associated protein 23, which regulates the fusion events of the secretory granule/plasma membrane after mast cell activation, resulting in degranulation. We showed that methiothepin blocked PMA/ionomycin‐induced phosphorylation of synaptosomal associated protein 23 by inhibiting its interaction with IκB kinase β. Together with the results of selective 5‐HT antagonists, it is suggested that methiothepin inhibits mast cell degranulation by downregulating upstream signaling pathways and exocytotic fusion machinery through mainly 5‐HT1A receptor. Our findings provide that 5‐HT antagonists may be used to relieve allergic reactions.
Divergent Total Syntheses of 2, 6‐Dioxabicyclo[3.3.1]nonan‐3‐one Styryllactones: (−)‐Goniopypyrone, (+)‐Goniochelienlactone and (+)‐7‐Acetylgoniochelienlactone
Authors: Cui Yuxin , Liang Changxu , Chen Minhao , Li Yong , Du Yuguo , Feng Fu , Liu Jun 
Published: September 2023

AbstractStereoselective total syntheses of (+)‐goniochelienlactone, (+)‐7‐acetylgoniochelienlactone and (−)‐goniopypyrone were accomplished by divergent strategies starting from readily available chiral pool methyl α‐D‐mannopyranoside. The present work provided an efficient strategy for the stereoselective construction of highly functionalized dioxabicyclo[3.3.1]nonan‐3‐one ring system through a sequential Bernet‐Vasella‐type reductive elimination/nucleophilic addition and a sequential cross‐metathesis/intramolecular oxa‐Michael addition in a one‐pot process.
In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of Drosophila melanogaster larval brain
Authors: Turna Demir Fatma , Demir Eşref 
Published: September 2023

AbstractAgriculture commonly utilizes crop protection products to tackle infestations from fungi, parasites, insects, and weeds. Validamycin A, an inhibitor of trehalase, possesses antibiotic and antifungal attributes. Epidemiological evidence has led to concerns regarding a potential link between pesticide usage and neurodegenerative diseases. The fruit fly, Drosophila melanogaster, has been recognized as a reliable model for genetic research due to its significant genetic similarities with mammals. Here, we propose to use D. melanogaster as an effective in vivo model system to investigate the genotoxic risks associated with exposure to validamycin A. In this study, we performed a neurotoxic evaluation of validamycin A in D. melanogaster larvae. Several endpoints were evaluated, including toxicity, intracellular oxidative stress (reactive oxygen species), intestinal damage, larval behavior (crawling behavior, light/dark sensitivity assay, and temperature sensitivity assay), locomotor (climbing) behavior, and neurogenotoxic effects (impaired DNA via Comet assay, enhanced by Endo III and formamidopyrimidine DNA glycosylase [FPG]). The results showed that exposure to validamycin A, especially at higher doses (1 and 2.5 mM), induced DNA impairment in neuroblasts as observed by Comet assay. Both larvae and adults exhibited behavioral changes and produced reactive oxygen species. Most importantly, this research represents a pioneering effort to report neurogenotoxicity data specifically in Drosophila larval neuroblasts, thus underscoring the importance of this species as a testing model in exploring the biological impacts of validamycin A. The in vivo findings from the experiments are a valuable and novel addition to the existing validamycin A neurogenotoxicity database.