bluuebunny/crossref_metadata_2025_split huggingface dataset:
MUNAROH: PENGEMBANGAN MULTIMEDIA KOSAKATA BAHASA ARAB DENGAN APLIKASI ISPRING SUITE PADA ANAK USIA DINI
Authors: Rahmawati Monica , Zukhaira Zukhaira , Busri Hasan 
Published: August 2023

This research is motivated by conditions in the field that lack of learning media, especially for the introduction of Arabic vocabulary for kindergarten / RA children. So far, teachers have only used picture cards and singing as media, but the implementation has not been maximized because the media is not dynamic enough to see the development of technology which is very fast now.
The problems studied in this study are (1) how to analyze teacher needs for the MUNAROH (Mufrodat Anak Raudhotul Athfal) Multimedia Arabic Vocabulary Media with the iSpring Suite Application for Kindergarten/RA Children in Semarang, (2) how is the prototype of MUNAROH, and (3) how is expert validation and revision of the MUNAROH (Mufrodat Anak Raudhotul Athfal) media prototype. The type of this research is qualitative and quantitative research (mixed method) with a research and development design(RnD).
The results of this study, first the teachers want MUNAROH media for TK/RA children group B. Second, the prototype of MUNAROH (Mufrodat Anak Roudhatul Athfal) is media in the form of educational games designed with a PC application display to make it easier for Kindergarten/RA teachers teach the introduction of Arabic to children in this all-digital pandemic era. Third, the results of expert validation include (1) aspects of the feasibility of content and material, (2) aspects of display, (3) aspects of software engineering, (4) aspects of communication, (5) aspects of audio and, (6) visual aspects. The result of obtaining the average overall score is 335.875. So, this learning method is declared feasible with a good predicate. Then, it can be concluded that the learning media “MUNAROH” is suitable to use.
Direct Instruction-Based Cooperative Learning Model Type Team Games Tournaments to Increase Learning Motivation and Social Attitudes
Authors: . Yorman , Lasmawan I Wayan , Sriatha I Putu , Kertih I Wayan 
Published: August 2023

This study is a quasi-experimental study using a non-equivalent post-test-only control group design as the study design, Middle school students were divided into two groups, the experimental group and the control group. Data were collected using observation sheets and questionnaires. The observation sheet was used to collect data about the application form of the direct instruction-based cooperative learning model type team games tournaments with the instilment of the local culture of Maja Labo Dahu. Moreover, questionnaires were used to collect data on learning motivation and social attitudes. The results showed that the direct instruction-based cooperative learning model type team games tournaments with the local culture of Maja Labo Dahu were significantly different from the conventional learning model in terms of learning motivation and social attitudes in students' Social Studies learning. Based on these findings, learning using the direct instruction-based cooperative learning model type team games tournaments with the local culture of Maja Labo Dahu has a better effect on increasing learning motivation and social attitudes than the conventional learning model. About the application form.
Simon Bacon, Eco-Vampires: The Undead and the Environment
Authors: Juengling Stephanie 
Published: August 2023

Simon Bacon, Eco-Vampires: The Undead and the Environment (Jefferson, North Carolina: McFarland Company, Inc., 2020), 207 pp., 45.00 (pbk), ISBN: 978-1-4766-7622-7.
LITERATURA E COAPRENDIZAGEM NA DOCÊNCIA: UM CAMINHO PELA LEITURA DE METAFICÇÃO
Authors: Fernandes Gildene Lima de Souza , Amarilha Marly , Freitas Alessandra Cardozo de 
Published: August 2023

Este artigo discorre sobre um estudo motivado pela necessidade de fomentar o debate acerca da mediação da formação leitora e escritora de crianças já alfabetizadas. Tem por objetivo analisar o potencial da literatura de metaficção para possibilitar a reflexão acerca das práticas de leitura e escrita literárias na escola. Fundamenta-se nos estudos sobre literatura, metaficção e ensino. Numa perspectiva qualitativa, se apoia nos princípios da análise de conteúdo para o estudo de textos orais e escritos de crianças do 5º ano do ensino fundamental, de uma escola pública de Natal/RN (Brasil), durante uma intervenção pedagógica constituída por sessões de leitura literária, de escrita e reescrita de textos autorais. Os resultados revelaram que a mediação para a escrita via leitura de metaficção constitui-se em um processo de coaprendizagem: as crianças se experimentaram como escritoras e a mediadora como interlocutora aprendiz dos processos de ler e escrever literatura.
Seismic Site Characterization in the Charlevoix Region, Québec
Authors: Molnar Sheri , Foulon Thomas , Sharma Hema , Ross Martin , Parent Michel 
Published: August 2023

Abstract
Significant earthquake site effect potential exists in Charlevoix, Québec, the most seismically active region in the eastern Canada. Most of the population there lives on two buried river valleys (Du Gouffre in the west and Malbaie in the east) filled by ≤350 m of glacial, glaciomarine, and fluvial deposits atop hard rock. To constrain seismic site conditions and material properties in the two buried river valleys, we performed 164 single-station microtremor measurements and passive- and active-source seismic array testing at six sites. Joint inversion of fundamental-mode Rayleigh-wave dispersion and microtremor horizontal-to-vertical spectral ratio (MHVSR) datasets was performed to obtain shear-wave velocity (VS) depth (z) profiles at the six array sites. The 164 calculated MHVSRs are used to obtain a spatial distribution of the MHVSR fundamental frequency (f0HV) within, and to define the boundaries of, the buried river valleys. The Du Gouffre River valley is marked by low f0HV (0.44–1 Hz), with f0HV increasing progressively from the valley center to its edges and decreasing southward toward the river mouth. The Malbaie River valley is marked by higher f0HV (1–2 Hz), with several areas of higher f0HV within the valley, indicating a shallower sediment depth. The inverted VS(z) profiles demonstrate that sediments are thickest (∼150 m) under Baie Saint-Paul at the mouth of the Du Gouffre River and thin to &lt;50 m headward as well as in the neighboring Malbaie valley. We compile our inverted VS(z) with other available VS(z) data in Charlevoix to derive a linear average VS–z relationship of Charlevoix soils. Soils in Charlevoix have an intermediate VS–z relationship between that of low VS soils in Ottawa–Gatineau and high VS soils in Montreal and Québec City. At greater depths, Charlevoix’s VS–z relationship is most similar to clays in nearby Saguenay, Québec.
Analisis Bibliometrik Pelayanan Publik untuk Penyandang Disabilitas
Authors: Salsabiila Marsaa , Yuadi Imam 
Published: August 2023

Pelayanan publik untuk penyandang disabilitas saat ini masih menjadi topik pembahasan yang perlu banyak dikaji. Masih banyak pelayanan publik yang tidak ramah akses untuk para penyandang disabilitas. Pelayanan publik yang tidak merata untuk para penyandang disabilitas yang dimana jumlah penyandang disabilitas tergolong cukup banyak menimbulkan adanya rasa iri atas ketimpangan yang diberikan oleh pemerintah kepada masyarakat. Tujuan penelitian ini adalah mengetahui perkembangan riset dalam melihat perkembangan pelayanan publik untuk penyandang disabilitas. Metode penelitian menggunakan analisis bibliometrik dalam memberikan gambaran terkait sebaran publikasi studi pada bidang pelayanan publik terkhususnya pelayanan publik untuk penyandang disabilitas. Analisis bibliometrik ini menerapkan limit dalam penentuan data yang akan digunakan dalam penelitian dengan melihat pertumbuhan penelitian terkait pelayanan publik untuk penyandang disabilitas. Hasil dari penerapan limit kemudian di export dalam format RIS dan BibTex. Format RIS digunakan pada visualisasi menggunakan bantuan aplikasi VOSviewer. Sedangkan format BibTex digunakan pada visualisasi menggunakan bantuan aplikasi Biblioshiny. Hasil akhir analisis bibliometrik ini adalah memvisualisasi jurnal dan penulis yang relevan dengan topik bahasan dan analyze result yang menghasilkan visualisasi dari bidang kategori yang relevan, jenis dokumen, afiliasi yang turut berkontribusi, persebaran wilayah, dan tingkat publikasi setiap tahun dari data 145 data dokumen. Visualisasi yang dihasilkan dari analisis bibliometrik ini selain dapat mempermudah memperoleh data dan memahami aspek-aspek pendukung dalam pembahasan pelayanan publik untuk penyandang disabilitas. Dapat juga memahami ada beberapa aspek yang kurang diteliti dalam adanya pelayanan publik untuk disabilitas.
Neuroprotective Effect of Naringin on Acrylamideinduced Cytotoxicity in U87MG Cells and Wistar Rats: An <i>in-vitro</i> and <i>in-vivo</i> Study
Authors: Vineela Sathuluri , Manga Devi Chinta , Santhrani Thakur 
Published: August 2023

Acrylamide (ACR) is a potent neurotoxic to humans and animals. Neuroprotective effect of naringin was evaluated on ACR induced cytotoxicity using U87MG cells as in-vitro model and rat as in vivo model. ACR (50 mg/kg, i.p.) and Naringin (50 & 100 mg/kg) were administered to rats for 4 weeks. After 4 weeks, rats were sacrificed and sciatic nerves were isolated to determine the biochemical and apoptotic parameters. The exposure of U87MG cells to ACR reduced cell viability. Pretreatment of cells with 5–300 Î¼g/ml naringin before ACR treatment signiï¬cantly attenuated ACR cytotoxicity in a dose-dependent manner. Naringin down-regulated the Bax and up-regulated the Bcl2 protein expression levels and also scavenged ACR induced free radicals in rats. In conclusion, our results indicated that pretreatment with naringin protected cells and rats from ACR-induced cytotoxicity and the neuroprotective effect was due to its antiapoptotic and antioxidant potential.
Amelioration of Streptozotocin Induced Cytotoxicity by <i>Mimosa pudica</i> Root Extract - A Proteomic Based In-Vitro Study
Authors: Jamadagni Pallavi S. , Pawar Sharad D. , Jamadagni Shrirang , Chougule Shridhar , Wanjari Manish , Gautam Manish , Gaidhani Sudesh , Gurav Arun , Shrikanth N. 
Published: August 2023

The in-vitrocytotoxicity was studied in a pancreatic cell line (RIN5F) using streptozotocin-induced cellular damage. The Cytotoxic dose of aqueous and hydro-alcoholic extracts of Mimosa pudica root powder before and after streptozotocin treatment was studied and protein expression was explored. Both the extracts were subjected to metabolite analysis by LCMS. Mimosa pudica root powder extracts prevented Streptozotocin-induced cellular damage. Proteomics studies indicated both aqueous and hydro-alcoholic extracts of Mimosa pudica regulate proteins related to insulin secretion, glucose uptake, and insulin resistance with marked changes in proteins involved in insulin secretion. The study first time reports cytotoxicity of Mimosa pudica in RIN5F cells and explores protein expression after Mimosa pudica treatment. It was also observed that the abundance of Mimosine is more in Hydro-alcoholic extracts as compared to aqueous extracts.
Comparing competitive team-based learning with other instructional methods and approaches
Authors: Hosseini Seyed Mohammad Hassan 
Published: August 2023

Having introduced Competitive Team-Based Learning (CTBL), this paper presents a cogent and critical analysis and comparison of CTBL with other popular methods and approaches in the arena of Education in general and Language Teaching in particular, in terms of their distinguishing features and characteristics. Among such methods and approaches are Communicative Language Teaching (CLT), Collaborative Learning (ColL), Interactive Learning (IntL), and Cooperative Learning (CL)/methods which are appreciated particularly in the U.S. and in the West. A synthesis of the distinguishing drawbacks of the comparison methods and approaches is considered in this article. The article also explicates how CTBL, this researcher’s educational innovation, which has been formulated based on his edu-political theories in the last analysis, is an approach to human security and prosperity, and world peace. This article would contribute to making a sound decision on implementing CTBL in the arena of Language Teaching/Education for the ultimate goal of peace-making and more compassionate civilization building.
Keywords: Competitive team-based learning; edu-political theories; interactive learning; cooperative learning; collaborative learning
Quantitative determination of total flavonoids in Glycyrrhiza Glabra L. herbs
Authors: Belova O. A. , Kurkin V. A. , Egorov M. V. 
Published: August 2023

Licorice herb (Glycyrrhiza glabra L.) is a promising herbal raw material, which can be comprehensively used to develop drugs with an anti-inflammatory action.The aim of the article was to development a quantitative determination method of total flavonoids in Glycyrrhiza glabra L. herbs.Materials and methods. The subjects of research were 5 samples of licorice herb harvested in summer in various places of growing and cultivation. Pinostrobin was used as a standard sample. The registration of the electronic spectra was carried out with a spectrophotometer (Analytik Jena AG, Germany) by differential spectrophotometry, 96% ethanol was used as a solvent.Results. The methods for quantitative determination of total flavonoids in Glycyrrhiza glabra L. was carried out at an analytical wavelength of 310 nm equivalent to pinocembrin. The optimum parameters for the extraction of total flavonoids from Glycyrrhiza glabra L. were as follows: the extractant – 90% ethanol; the «raw material-extractant» ratio was 1:50; the extraction time was 60 min; the degree of atomization was 2 mm. The content of total flavonoids for the Glyccyrhiza glabra L. herb has been determined, it varies from 0.39±0.002 to 3.41±0.015% with the humidity of the vegetative raw material from 9.97±0.003 to 10.03±0.003% depending on the place of the vegetation, cultivation and year of the raw material collection. The error of the single determination with a 95% confidence level was ±0.73%.Conclusion. The developed methods for the quantitative determination of total flavonoids in Glycyrrhiza glabra L. herbs can be used to solve the issues of standardization of these medicinal plant raw materials.
Analysis of cytokine response characteristics and immunopathogenetic effects of double-stranded sodium salt RNA-based drug for postexposure prophylaxis against novel coronavirus infection: double-blind, placebo-controlled trial
Authors: Radaeva O. A. , Balykova L. A. , Zaslavskaya K. Ya. , Kostina Yu. A. , Pyataev N. A. , Selezneva N. M. , Klimova A. V. , Chegodaeva I. Yu. , Koryanova K. N. , Taganov A. V. , Bely P. A. 
Published: August 2023

The aimof the workwas to study сytokine response characteristicsin the group of persons contacted by a novel coronavirus infection depending on the development of the disease over the next 14 days. Herewith, for the immunocorrection with a preparation based on RNA double-stranded sodium salt (RADAMIN®VIRO) causing a secondary reduction in the risk of COVID-19 in the analyzed group, potential targets had been selected.Materials and methods.A double-blind, placebo-controlled study of the drug based on RNA double-stranded sodium salt therapeutic effects was conducted in a group of patients who had been in contact with the persons having a confirmed diagnosis of COVID-19. The method of enzyme immunoassay in dynamics was used to determine the content of interferons alpha and beta (IFNα and IFNβ, respectively), interleukin-1β and -10 (IL1β and IL-10, respectively) in the blood serum and saliva in the contact persons, with a retrospective assessment of changes depending on the administration of the drug or placebo, as well as the development of COVID-19.Results.In the course of the presented study, it was demonstrated that the established content of IFNα (less than 28 pg/ml) and IFNβ (less than 12 pg/ml) in saliva on the 1st–2ndcontact days is a predictor of an increased risk of developing COVID-19. Herewith, the increase degree in these immunoregulatory peptides in the interval of 2–3 contact days is important: IFNα and IFNβ allows leveling the negative prognosis in patients by 250% or more. The lowest rates (p <0.001) of INFα on the 1st–2ndcontact days, as well as an increase of less than 21% by the 3rdday, were observed in persons with a waist circumference of more than 80/94 cm (women/men). The incidence in this group was higher and amounted to 85% (16 out of 20 people). The predictor role of IL-1β and IL-10 in the blood and saliva in relation to the start of the infectious process was not revealed. The administration of drug based on RNA double-stranded sodium salt to the contact patients made it possible to correct the interferon response in the form of an increase in the content of IFNα and IFNβ, as well as to reduce the incidence in comparison with the placebo group.Conclusion.Differences in the interferon regulation upon contact with SARS-CoV-2 in the form of lower INF α and β levels, as well as a slightly pronounced growth dynamics in the interval of the first 3 days, influenced the increased risk of developing COVID-19. RADAMIN®VIRO can be recommended as a means of post-exposure prophylaxis of COVID-19 for both medical institutions and for caregivers and / or contacts with COVID-19 patients.
New role of extemporaneous manufacturing in regulating drug products access onto the market
Authors: Alekhin A. V. , Erivantseva T. N. , Ryazhenov V. V. , Lyskov N. N. , Alekhina N. A. , Kuznetsova M. M. 
Published: August 2023

The aim of the work was to study the legal aspects of the legislative regulation for manufacturing medicines in a pharmacy organization.Materials and methods. Databases of ConsultantPlus, Cyberleninka, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Center for Biotechnology Information (NCBI), PubMed, e-library, WIPO Lex were used as search sources. The search was based on the following keywords and phrases: intellectual property, pharmacies+invention, patent, drugs, extemporal+production, orphan+diseases, as well as their Russian counterparts. 133 sources of information, including scientific articles and regulations, were found out; 50 have been included in this review. The analysis of information sources published from 2013 to 2023, was determined by the peculiarities of legislation changes in this area.Results. The article provided an overview of modern, including regulatory practice, pharmaceutical manufacturing in the Russian Federation, and also analyzed the benefits of this activity for the medical community, patients and the state. At the same time, the individualization of drug treatment has made it possible to work out systemic solutions for developing drug therapy methods for special groups of patients for whom the economic feasibility of a pharmaceutical registration and launching such drugs onto the market has been brought into challenge. In addition, pharmacy manufacturing is an accessible tool in the study of the drugs prescribed by a doctor not in accordance with the instructions for medical use (off-label) or in the dosage forms/dosages that are not on the market. Extemporaneous manufacturing can be also a part of the process of “repositioning” drugs on the market, subject to compliance with the requirements for pharmacy manufacturing and control of the prescribed drugs safety. The possibility of pharmaceutic drug manufacturing also makes it possible to partially resolve issues related to intellectual property. As a result of the carried out analysis, the following hypothesis was confirmed: the legislative changes have a similar legal assessment both in Russia and abroad and correspond to the legal practice in resolving intellectual property issues in relation to pharmacy organizations.Conclusion. The renewal of a pharmacy production will improve the availability of the drug care to the population, taking into account individual dosages and dosage forms in various therapeutic areas, and can also become a tool for repositioning drugs or clinical testing of new molecules for rare incurable diseases.
The Law Tech Clinic: Leading the way in Entrepreneurial Law Clinics
Authors: Weinberg Jacqueline , Hyams Ross 
Published: August 2023

Globalisation, economic forces and technological advancements are changing the way law is practised. Clients are seeking innovative solutions to an increasingly broad range of legal challenges. They want greater connectivity and streamlined delivery of legal services. The rate of change has accelerated in response to remote working, with the digital maturity of legal firms advancing more rapidly than ever before, utilising technology such as electronic billing practices, digital mailrooms, e- discovery, digital document signing and workflow automation.
Newly developed and deployed legal technology within the sector has increased demand for lawyers with the skills to adapt and thrive in a technological environment. Law firms favour graduates with a ‘technology mindset’ and aptitude to think beyond the traditional professional services model. The Monash University Faculty of Law, one of the leading law schools in Australia with a pioneering clinical program, has established a Law Tech Clinic (LTC). The LTC provides a unique opportunity for students to work on real client matters and receive end-to-end industry input to develop client-ready applications.
This paper describes the LTC’s structure and how the clinic is designed to educate students on the changing demands of the legal industry, providing practical knowledge on legal technology usage to advance legal services. This paper outlines how the LTC enables students to develop professional and practical legal skills that will help them become successful entrepreneurial lawyers, adept at integrating technology with innovative legal services. Further, this paper demonstrates how the Monash Clinical Program, with a strong focus on best practice in clinical legal education, provides a perfect forum to run such a clinic. We demonstrate how students work with technological systems to assist industry partners, law firms and other organisations and provide accessible legal services to their clients.2 Finally, this paper highlights how the LTC educates students on technological advances in legal practice, equipping them with frameworks for the knowledge, skills and attributes to be technologically proficient future legal practitioners. Although this discussion is in the Australian context, it can also apply to other jurisdictions as the associated issues with legal technology and its effects on legal practice are occurring globally.