bluuebunny/crossref_metadata_2025_split huggingface dataset:
Race, ethnicity, and clinical outcome following sport-related concussion: a systematic review
Authors: Cook Nathan E. , Gaudet Charles E. , Kissinger-Knox Alicia , Liu Brian C. , Hunter Amy A. , Norman Marc A. , Saadi Altaf , Iverson Grant L. 
Published: June 2023

IntroductionThis systematic review examined whether race or ethnicity are associated with clinical outcomes (e.g., time to return to school/sports, symptom duration, vestibular deficits, and neurocognitive functioning) following sport-related concussion among child, adolescent, or college-aged student athletes. Additionally, this review assessed whether the existing literature on this topic incorporated or included broader coverage of social determinants of health.MethodsThe online databases PubMed, MEDLINE®, PsycINFO®, CINAHL, Cochrane Library, EMBASE, SPORTDiscus, Scopus, and Web of Science were searched.ResultsA total of 5,118 abstracts were screened and 12 studies met inclusion criteria, including 2,887 youth and young adults. Among the included articles, only 3 studies (25%) examined whether race and ethnicity were associated with outcomes following concussion as a primary objective. None of the studies assessed the association between social determinants of health and outcomes following concussion as a primary objective, although 5 studies (41.7%) addressed a social determinant of health or closely related topic as a secondary objective.DiscussionOverall, the literature to date is extremely limited and insufficient for drawing conclusions about whether race or ethnicity are categorically associated with outcomes from sport-related concussion, or more specifically, whether there are socioeconomic, structural, or cultural differences or disparities that might be associated with clinical outcome.Systematic review registrationidentifier: PROSPERO, CRD42016041479, CRD42019128300.
Mammographic density in relation to breast cancer recurrence and survival in women receiving neoadjuvant chemotherapy
Authors: Zdanowski Anna , Sartor Hanna , Feldt Maria , Skarping Ida 
Published: June 2023

ObjectiveThe association between mammographic density (MD) and breast cancer (BC) recurrence and survival remains unclear. Patients receiving neoadjuvant chemotherapy (NACT) are in a vulnerable situation with the tumor within the breast during treatment. This study evaluated the association between MD and recurrence/survival in BC patients treated with NACT.MethodsPatients with BC treated with NACT in Sweden (2005–2016) were retrospectively included (N=302). Associations between MD (Breast Imaging-Reporting and Data System (BI-RADS) 5th Edition) and recurrence-free/BC-specific survival at follow-up (Q1 2022) were addressed. Hazard ratios (HRs) for recurrence/BC-specific survival (BI-RADS a/b/c vs. d) were estimated using Cox regression analysis and adjusted for age, estrogen receptor status, human epidermal growth factor receptor 2 status, axillary lymph node status, tumor size, and complete pathological response.ResultsA total of 86 recurrences and 64 deaths were recorded. The adjusted models showed that patients with BI-RADS d vs. BI-RADS a/b/c had an increased risk of recurrence (HR 1.96 (95% confidence interval (CI) 0.98–3.92)) and an increased risk of BC-specific death (HR 2.94 (95% CI 1.43–6.06)).ConclusionThese findings raise questions regarding personalized follow-up for BC patients with extremely dense breasts (BI-RADS d) pre-NACT. More extensive studies are required to confirm our findings.
Skeletal muscle contributions to reduced fitness in cystic fibrosis youth
Authors: Tomlinson Owen William , Barker Alan Robert , Fulford Jonathan , Wilson Paul , Shelley James , Oades Patrick John , Williams Craig Anthony 
Published: June 2023

BackgroundIncreased maximal oxygen uptake (V̇O2max) is beneficial in children with cystic fibrosis (CF) but remains lower compared to healthy peers. Intrinsic metabolic deficiencies within skeletal muscle (muscle “quality”) and skeletal muscle size (muscle “quantity”) are both proposed as potential causes for the lower V̇O2max, although exact mechanisms remain unknown. This study utilises gold-standard methodologies to control for the residual effects of muscle size from V̇O2max to address this “quality” vs. “quantity” debate.MethodsFourteen children (7 CF vs. 7 age- and sex-matched controls) were recruited. Parameters of muscle size – muscle cross-sectional area (mCSA) and thigh muscle volume (TMV) were derived from magnetic resonance imaging, and V̇O2max obtained via cardiopulmonary exercise testing. Allometric scaling removed residual effects of muscle size, and independent samples t-tests and effect sizes (ES) identified differences between groups in V̇O2max, once mCSA and TMV were controlled for.ResultsV̇O2max was shown to be lower in the CF group, relative to controls, with large ES being identified when allometrically scaled to mCSA (ES = 1.76) and TMV (ES = 0.92). Reduced peak work rate was also identified in the CF group when allometrically controlled for mCSA (ES = 1.18) and TMV (ES = 0.45).ConclusionsA lower V̇O2max was still observed in children with CF after allometrically scaling for muscle size, suggesting reduced muscle “quality” in CF (as muscle “quantity” is fully controlled for). This observation likely reflects intrinsic metabolic defects within CF skeletal muscle.
A report on SARS-CoV-2 first wave in Ecuador: drug consumption dynamics
Authors: Orellana-Manzano Andrea , Cordeiro Fernanda B. , Garcia-Angulo Andrea , Centeno Elizabeth , Vizcaíno-Tumbaco María José , Poveda Sebastián , Murillo Ricardo , Andrade-Molina Derly , Mirabá Mariuxi , Mehta Saurabh , Cárdenas Washington 
Published: June 2023

Introduction: The first COVID-19 wave in Ecuador started in March 2020 and extended until November. Several types of drugs have been proposed as a potential treatment during this period, and some affected people have self-medicated.Method: A retrospective study was conducted with 10,175 individuals who underwent RT-PCR tests for SARS-CoV-2 from July to November 2020. We compared the number of positive and negative cases in Ecuador with symptoms and drug consumption. The Chi-square test of independence compared clinical and demographic data and PCR test results. Odds ratios analyzed drug consumption dynamics.Results: Of 10,175 cases, 570 were positive for COVID-19, while 9,605 were negative. In positive cases, there was no association between the RT-PCR result and sex, age, or comorbidities. When considering demographic data, Cotopaxi and Napo had the highest rates of positive cases (25.7% and 18.8%, respectively). Manabí, Santa Elena, and Guayas regions had fewer than 10% positive cases. The Drug consumption dynamic analysis showed that negative COVID-19 cases presented higher drug consumption than positive cases. In both groups, the most consumed medication was acetaminophen. Acetaminophen and Antihistamines had higher odds of consumption in positive PCR cases than in negative. Symptoms like fever and cough were more related to positive RT-PCR results.Conclusion: The first COVID-19 wave in Ecuador has affected the provinces differently. At a national level, the consumption of drugs has been highly associated with self-medication.
Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors
Authors: Zhang Xiaoyi , Jiang Lingna , Li Yixin , Feng Qiqi , Sun Xiulin , Wang Yaonan , Zhao Ming 
Published: June 2023

Introduction: Protein p97 is an extensively investigated AAA ATPase with various cellular activities, including cell cycle control, ubiquitin–proteasome system, autophagy, and NF-κB activation.Method: In this study, we designed, synthesized and evaluated eight novel DBeQanalogs as potential p97 inhibitors in vivo and in vitro.Results: In the p97 ATPase inhibition assay, compounds 6 and 7 showed higher potency than the known p97 inhibitors, DBeQ and CB-5083. Compounds 4-6 dramatically induced G0/G1 phase arrest in the HCT116 cells, and compound 7 arrested the cells in both G0/G1 and S phases. Western blots showed elevated levels of SQSTM/p62, ATF-4, and NF-κB in HCT116 cells with the treatment of compounds 4–7, confirming their role in inhibiting the p97 signaling pathway in cells. In addition, the IC50 of compounds 4–6 against HCT116, RPMI-8226, and s180 proliferation were 0.24–6.9 µM with comparable potency as DBeQ. However, compounds 4–6 displayed low toxicity against the normal human colon cell line. Thus, compounds 6 and 7 were proved to be potential p97 inhibitors with less cytotoxicity. In vivo studies using the s180 xenograft model have demonstrated that compound 6 inhibited tumor growth, led to a significant reduction of p97 concentration in the serum and tumor, and indicated non-toxicity on the body weight and organ-to-brain weight ratios except for the spleen at the dose of 90 μmol/kg/day for 10 days. Furthermore, the present study indicated that compound 6 may not induce s180 mice myelosuppression often observed in the p97 inhibitors.Conclusion: Compound 6 displayed high binding affinity to p97, great p97 ATPase inhibition, selective cytotoxicity, remarkable anti-tumor effect, and upregulated safety, which improved the clinical potential of p97 inhibitors.
Molecular determinants of TRPM8 function: key clues for a cool modulation
Authors: Pertusa María , Solorza Jocelyn , Madrid Rodolfo 
Published: June 2023

Cold thermoreceptor neurons detect temperature drops with highly sensitive molecular machinery concentrated in their peripheral free nerve endings. The main molecular entity responsible for cold transduction in these neurons is the thermo-TRP channel TRPM8. Cold, cooling compounds such as menthol, voltage, and osmolality rises activate this polymodal ion channel. Dysregulation of TRPM8 activity underlies several physiopathological conditions, including painful cold hypersensitivity in response to axonal damage, migraine, dry-eye disease, overactive bladder, and several forms of cancer. Although TRPM8 could be an attractive target for treating these highly prevalent diseases, there is still a need for potent and specific modulators potentially suitable for future clinical trials. This goal requires a complete understanding of the molecular determinants underlying TRPM8 activation by chemical and physical agonists, inhibition by antagonists, and the modulatory mechanisms behind its function to guide future and more successful treatment strategies. This review recapitulates information obtained from different mutagenesis approaches that have allowed the identification of specific amino acids in the cavity comprised of the S1-S4 and TRP domains that determine modulation by chemical ligands. In addition, we summarize different studies revealing specific regions within the N- and C-terminus and the transmembrane domain that contribute to cold-dependent TRPM8 gating. We also highlight the latest milestone in the field: cryo-electron microscopy structures of TRPM8, which have provided a better comprehension of the 21 years of extensive research in this ion channel, shedding light on the molecular bases underlying its modulation, and promoting the future rational design of novel drugs to selectively regulate abnormal TRPM8 activity under pathophysiological conditions.
The combined analysis of urine and blood metabolomics profiles provides an accurate prediction of the training and competitive status of Chinese professional swimmers
Authors: Yang Ruoyu , Wang Yi , Yuan Chunhua , Shen Xunzhang , Cai Ming , Wang Liyan , Hu Jingyun , Song Haihan , Wang Hongbiao , Zhang Lei 
Published: June 2023

Objective: The purpose of this study was to employ metabolomics for the analysis of urine metabolites in swimmers, with the aim of establishing models for assessing their athletic status and competitive potential. Furthermore, the study sought to compare the identification efficacy of multi-component (urine and blood) model versus single-component (urine or blood) models, in order to determine the optimal approach for evaluating training and competitive status.Methods: A total of 187 Chinese professional swimmers, comprising 103 elite and 84 sub-elite level athletes, were selected as subjects for this study. Urine samples were obtained from each participant and subjected to nuclear magnetic resonance (NMR) metabolomics analysis. Significant urine metabolites were screened through multivariable logistic regression analysis, and an identification model was established. Based on the previously established model of blood metabolites, this study compared the discriminative and predictive performance of three models: either urine or blood metabolites model and urine + blood metabolites model.Results: Among 39 urine metabolites, 10 were found to be significantly associated with the athletic status of swimmers (p &lt; 0.05). Of these, levels of 2-KC, cis-aconitate, formate, and LAC were higher in elite swimmers compared to sub-elite athletes, while levels of 3-HIV, creatinine, 3-HIB, hippurate, pseudouridine, and trigonelline were lower in elite swimmers. Notably, 2-KC and 3-HIB exhibited the most substantial differences. An identification model was developed to estimate physical performance and athletic level of swimmers while adjusting for different covariates and including 2-KC and 3-HIB. The urine metabolites model showed an area under the curve (AUC) of 0.852 (95% CI: 0.793–0.912) for discrimination. Among the three identification models tested, the combination of urine and blood metabolites showed the highest performance than either urine or blood metabolites, with an AUC of 0.925 (95% CI: 0.888–0.963).Conclusion: The two urine metabolites, 2-KC and 3-HIV, can serve as significant urine metabolic markers to establish a discrimination model for identifying the athletic status and competitive potential of Chinese elite swimmers. Combining two screened urine metabolites with four metabolites reported exhibiting significant differences in blood resulted in improved predictive performance compared to using urine metabolites alone. These findings indicate that combining blood and urine metabolites has a greater potential for identifying and predicting the athletic status and competitive potential of Chinese professional swimmers.
ASFL-YOLOX: an adaptive spatial feature fusion and lightweight detection method for insect pests of the Papilionidae family
Authors: Xu Lijia , Shi Xiaoshi , Tang Zuoliang , He Yong , Yang Ning , Ma Wei , Zheng Chengyu , Chen Huabao , Zhou Taigang , Huang Peng , Wu Zhijun , Wang Yuchao , Zou Zhiyong , Kang Zhiliang , Dai Jianwu , Zhao Yongpeng 
Published: June 2023

IntroductionInsect pests from the family Papilionidae (IPPs) are a seasonal threat to citrus orchards, causing damage to young leaves, affecting canopy formation and fruiting. Existing pest detection models used by orchard plant protection equipment lack a balance between inference speed and accuracy.MethodsTo address this issue, we propose an adaptive spatial feature fusion and lightweight detection model for IPPs, called ASFL-YOLOX. Our model includes several optimizations, such as the use of the Tanh-Softplus activation function, integration of the efficient channel attention mechanism, adoption of the adaptive spatial feature fusion module, and implementation of the soft Dlou non-maximum suppression algorithm. We also propose a structured pruning curation technique to eliminate unnecessary connections and network parameters.ResultsExperimental results demonstrate that ASFL-YOLOX outperforms previous models in terms of inference speed and accuracy. Our model shows an increase in inference speed by 29 FPS compared to YOLOv7-x, a higher mAP of approximately 10% than YOLOv7-tiny, and a faster inference frame rate on embedded platforms compared to SSD300 and Faster R-CNN. We compressed the model parameters of ASFL-YOLOX by 88.97%, reducing the number of floating point operations per second from 141.90G to 30.87G while achieving an mAP higher than 95%.DiscussionOur model can accurately and quickly detect fruit tree pest stress in unstructured orchards and is suitable for transplantation to embedded systems. This can provide technical support for pest identification and localization systems for orchard plant protection equipment.
Postpartum depression literacy in Chinese perinatal women: a cross-sectional study
Authors: Huang Weijian , Li Guiqin , Wang Dongmei , Qu Hua , Tian Maozhou , Wang Yanmei 
Published: June 2023

BackgroundPostpartum depression literacy is a specific mental health literacy that can help perinatal women identify, manage, and prevent postpartum depression. However, the current status and associated factors of postpartum depression literacy among Chinese perinatal women are still unclear. This study investigated postpartum depression literacy and its associated factors among this group.MethodsA cross-sectional survey was conducted involving 386 cases of perinatal women using the convenience sampling method. Participants completed four questionnaires to evaluate their general characteristics, postpartum depression literacy, perceived social support, and general self-efficacy. The SPSS 24.0 software was used for descriptive statistical analysis, univariate analysis, and multivariate analysis.ResultsThe total PoDLiS score was (3.56 ± 0.32). The factors that composed the final multiple regression equation included planned pregnancy condition (β = −0.137, p = 0.003), education (β = 0.127, p &lt; 0.001), history of depression (β = −0.271, p &lt; 0.001), social support (β = 0.0012, p &lt; 0.001), self-efficacy (β = 0.030, p &lt; 0.001), and complications (β = −0.0191, p = 0.0019). They accounted for 32.8% of the total postpartum depression literacy variation (R2 = 0.328, F = 24.518, p &lt; 0.001).ConclusionThe findings of this study improved our understanding of perinatal women’s postpartum depression literacy and its associated factors. Women with low postpartum depression literacy urgently need to be identified. Comprehensive nursing intervention measures should be taken from six dimensions of mental health literacy, social support, and self-efficacy to improve the postpartum depression literacy of perinatal women.
Higher adherence to the Dietary Approaches to Stop Hypertension (DASH Diet) is associated with lower greenhouse gases and land use from protein foods
Authors: Kling Nicole R. , Rosentrater Kurt A. , Lee Duck-Chul , Brellenthin Angelique G. , Lanningham-Foster Lorraine 
Published: June 2023

IntroductionThe average American diet is high in red and processed meats which increases one's risk for chronic diseases and requires more land and water to produce and yields greater greenhouse gases (GHG) compared to other protein foods. Reduction of red and processed meat intake, such as seen with the Dietary Approaches to Stop Hypertension (DASH diet), could benefit human and environmental health.ObjectiveThe objective of this study is to predict the environmental sustainability of the DASH diet by evaluating the GHG, land use, and water withdrawals from protein foods within the self-selected diets of people who were encouraged to follow the DASH diet.MethodsDietary data was collected from 380 Midwesterners aged 35-70 years old with hypertension using the Automated Self-Administered 24-Hour (ASA 24) Recall System. DASH diet adherence was measured using a nutrient-based DASH score. GHG, land use, and water withdrawals were obtained using Carnegie Mellon University's Economic Input-Output Life Cycle Assessment (eiolca.net) using the Purchaser model (cradle-to-consumer). Multiple linear regressions were used to view associations between individual DASH nutrient scores and environmental impacts of total, animal, and plant protein foods.ResultsDiets that met DASH diet guidelines, as indicated by higher individual DASH nutrient scores, were associated with less GHG and land use from total and animal protein foods but more GHG and land use from plant-protein foods, with a few exceptions. The pattern was not clear for water withdrawals. Diets with the greatest adherence had around 25–50% lower GHG and land use from total protein foods than diets with the lowest adherence. Changes may be due to decreased consumption of total and animal protein foods, selection of animal protein foods with lower environmental impacts, and increased consumption of plant protein foods.ConclusionAdhering to the DASH diet can promote the consumption of less environmentally demanding protein foods resulting in lower GHG and land use from protein foods. However, claims regarding the sustainability of the entire dietary pattern cannot be determined based off the current study. Regardless, it is evident that environmental impacts should be considered alongside health impacts when selecting, promoting, or recommending a dietary pattern.
Epigenetic analysis in a murine genetic model of Gulf War illness
Authors: Mozhui Khyobeni , O’Callaghan James P. , Ashbrook David G. , Prins Pjotr , Zhao Wenyuan , Lu Lu , Jones Byron C. 
Published: June 2023

Of the nearly 1 million military personnel who participated in the 1990–1991 Gulf War, between 25% and 35% became ill with what now is referred to as Gulf War Illness (GWI) by the Department of Defense. Symptoms varied from gastrointestinal distress to lethargy, memory loss, inability to concentrate, depression, respiratory, and reproductive problems. The symptoms have persisted for 30 years in those afflicted but the basis of the illness remains largely unknown. Nerve agents and other chemical exposures in the war zone have been implicated but the long-term effects of these acute exposures have left few if any identifiable signatures. The major aim of this study is to elucidate the possible genomic basis for the persistence of symptoms, especially of the neurological and behavioral effects. To address this, we performed a whole genome epigenetic analysis of the proposed cause of GWI, viz., exposure to organophosphate neurotoxicants combined with high circulating glucocorticoids in two inbred mouse strains, C57BL/6J and DBA/2J. The animals received corticosterone in their drinking water for 7 days followed by injection of diisopropylfluorophosphate, a nerve agent surrogate. Six weeks after DFP injection, the animals were euthanized and medial prefrontal cortex harvested for genome-wide DNA methylation analysis using high-throughput sequencing. We observed 67 differentially methylated genes, notably among them, Ttll7, Akr1c14, Slc44a4, and Rusc2, all related to different symptoms of GWI. Our results support proof of principle of genetic differences in the chronic effects of GWI-related exposures and may reveal why the disease has persisted in many of the now aging Gulf War veterans.