bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular Complications of Immune Effector Cell Therapies in Pediatric Hematological and Solid Tumors
Authors: Ross Aaron B. , Puri Kriti , Johnson Thomas L. , Correa Lilliam D. , John Tami D. , Friend Brian , Navai Shoba A. , Ahmed Nabil , Hegde Meenakshi G. , Omer Bilal , Heczey Andras , Salem Baheyeldin M. , Tcharmtchi Hossein , Rouce Rayne H. , Steffin David H. , Krance Robert A , Rainusso Nino C. , Bhar Saleh 
Published: January 2025

ABSTRACTBackgroundImmune effector cell (IEC) therapies, including chimeric antigen receptor (CAR)‐modified T‐cell therapy, have shown efficacy in pediatric B‐cell acute lymphoblastic leukemia (B‐ALL) and are being investigated for other malignancies. A common toxicity associated with IEC therapy is cytokine release syndrome (CRS), which can lead to cardiovascular decompensation due to systemic inflammation. Data are limited regarding cardiovascular adverse effects in children. This study aims to describe the cardiovascular adverse effect profile of IEC therapies in pediatric patients with hematologic and solid tumor malignancies.MethodsWe retrospectively reviewed patients who received IECs directed towards various targets in patients with hematologic, solid, and brain tumor malignancies from January 2014 to June 2023 at Texas Children's Hospital. The primary end point was hypotension requiring vasoactive support and/or heart failure within 30 days of infusion.ResultsA total of 203 patients met inclusion criteria. Pretreatment echocardiogram was available for 142 (70%) pediatric patients, of whom 140 (96%) had normal baseline systolic function. Hypotension requiring vasoactive support occurred in 26 (13%) patients. Hematologic malignancy indications (p = 0.002), total body irradiation (TBI) (p = 0.002), and allogenic hematopoietic stem cell transplants (HCT) (p = 0.035) were associated with increased risk of hypotension requiring vasoactive support. Follow‐up echocardiograms were available for 14 patients who met the primary end point, and all showed return to baseline within 6 months.ConclusionsSignificant hemodynamic compromise occurred in a minority of patients treated with IEC therapies. All experiencing cardiac dysfunction had recovery of function, and there was no cardiovascular‐related mortality.
Registration of soybean germplasm DS1260‐2, with improved tolerance to mature seed damage and Phomopsis seed decay
Authors: Smith James R. , Gillen Anne M. , Li Shuxian , Abbas Hamed K. , Sulyok Michael , Shier W. Thomas , Mengistu Alemu , Cai Guohong , Gillman Jason D. 
Published: January 2025

AbstractDamage to mature soybean [Glycine max (L.) Merr.] seed occurs when mature seeds are subjected to weathering, fungi, and insects under hot humid conditions. Such damage can be exacerbated by delays in harvest. Mature seed damage (MSD) causes lost revenue to both producers and processors, as well as lower quality of the seed, protein meal, and oil to consumers. The release of DS1260‐2 (Reg. no. GP‐531, PI 705148) by the USDA‐ARS is part of our effort to increase soybean tolerance to mature seed damage using traditional plant breeding. Tolerance to MSD was derived from exotic accession Huang mao bai shui dou (PI 587982A) and incorporated through pedigree selection into an agronomically improved conventional late maturity group IV germplasm adapted for production in the midsouthern United States. DS1260‐2 has significantly lower levels of seed damage than cultivars ‘P46T59R’, ‘AG4632’, and ‘P48A60X’, which manifests as lower incidence of Diaporthe longicolla (Hobbs) J.M. Santos (Syn. Phomopsis longicolla Hobbs), less seed coat wrinkling and visual mold, lower incidence of fungal metabolites (nivalenol, cercosporin, cytochalasins H and J, tryptophol, fusaric acid, and beauvericin), and higher seed germination. DS1260‐2 yielded similar to P46T59R in trials over 4 years in Mississippi, but less than ‘AG46X6’, ‘AG48X9’, and ‘S16‐7922C’ in regional testing. DS1260‐2 is resistant to southern stem canker, frogeye leaf spot, and race 3 (HG type 0) of soybean cyst nematode. DS1260‐2 is a valuable source for developing cultivars with improved tolerance to the MSD that is caused by mold and weathering.
Using Multiple Anthropomorphic Measures to Estimate Height in Muscular Dystrophies and Its Impact on Lung Function
Authors: Whitley Kayleen , Spoede Elizabeth , Moore Glenn , Farber Harold J. 
Published: January 2025

ABSTRACTBackgroundAn accurate height estimate is important for assessing pulmonary function, and body mass index. If a patient cannot stand, an accurate standing height cannot be directly measured. Knee‐heel length, arm span, ulnar length, and tibial length have been studied in otherwise healthy populations as single measurements for height estimation.ObjectiveTo determine the relation of ulnar length, tibial length, arm span, and knee‐heel length to standing height in children with neuromuscular diseases.MethodsChildren and adolescents with neuromuscular diseases were recruited for participation. Knee–heel length, ulnar length, tibial length, arm span, and standing height (in those who could stand) were measured. Height estimation models were built using multivariate regression with backward elimination with criteria to eliminate as p > 0.20. Our results were compared to other published height estimation models.ResultsWe enrolled 28 children with a neuromuscular diagnosis who were able to stand. Models for standing height that combined arm span, ulnar length, and tibia length provided the best estimates, yielding an adjusted R square of 0.95 and a mean difference from measured height of 2.7 cm for a 5% difference in predicted forced vital capacity (FVC). Other models yielded a 5–7 cm difference between estimated and standing height for an 8.5%–12% difference in predicted FVC. We enrolled 30 children not able to stand. The mean ratios of anthropomorphic measures were similar in those who could not stand compared to those who could stand.ConclusionsA model combining three measurements of arm span, ulnar length, and tibial length together provided the best height estimation for patients with neuromuscular disease. Final height estimation model: (arm span [cm] × 0.457) + (ulnar length [cm] × 1.292) + (tibial length [cm] × 0.902) + 17.745 = Standing Height.
Optimizing Lognormal Process Monitoring With Bayesian Approach for Industrial Engineering Applications
Authors: Khan Imad , Abbas Tahir , Albogamy Fahad R. 
Published: January 2025

ABSTRACTIn this article, we introduce the Bayesian adaptive Max‐EWMA control chart designed to monitor both the mean and variance of processes following a lognormal distribution. By employing various loss functions, our Bayesian control chart demonstrates robust performance in detecting shifts in both the mean and dispersion across a wide range of magnitudes. We utilize Monte Carlo simulation techniques to compute run length characteristics, providing a thorough comparative analysis of the proposed chart against existing control charts in terms of run length performance. Our findings reveal the superior sensitivity of the Bayesian control chart to shifts of different magnitudes. To illustrate the practical applicability of our approach, we present a case study on the hard‐bake process in semiconductor manufacturing, showcasing its effectiveness when applying various loss functions. In conclusion, our research highlights the enhanced performance of the proposed Bayesian chart in detecting out‐of‐control signals.
Immunobiology of MPox Infection and Its Management: Experience From Developing Nations
Authors: Sahoo Om Saswat , Sapam Daina , Ajmeria Swati , Aidasani Hiya , Dhar Ruby , Karmakar Subhradip 
Published: January 2025

ABSTRACTPurposeAs humanity grapples with the COVID‐19 pandemic caused by the novel SARS‐CoV‐2 virus, the rising threats of the MPox virus (MPXV) in 2022 and 2024 have shown signs of global transmission and the potential to spark another pandemic. Though MPXV has been present for over 5 decades, with cases traditionally confined to endemic regions in West and Central Africa, recent outbreaks have occurred in multiple non‐endemic regions, declaring itself as a Public Health Emergency of International Concern. This study aims to examine the patterns of MPXV transmission, its zoonotic potential, associated complications, and viable strategies to control its spread.MethodsThe study examines recent outbreak data, case reports, and literature on MPXV transmission, emphasising zoonotic pathways and healthcare‐associated cases. A bibliometric analysis has also been performed to deepen the understanding and identify emerging research trends.ResultsThe findings suggest that while MPXV has traditionally been endemic in certain regions of Africa, recent outbreaks indicate an increased transmission risk in non‐endemic countries, raising concerns about potential global spread. Data reveals that much of the transmission has occurred within healthcare settings. Additionally, global research on the outbreak remains limited and requires further exploration from various perspectives, emphasising the need for prompt intervention.ConclusionContaining MPXV's spread is essential to prevent another potential pandemic. Effective management and control strategies, including enhanced surveillance, public health interventions, and targeted education within at‐risk communities, are critical to mitigate the spread and impact of MPXV globally. This study advocates for a proactive approach to MPXV control to avoid its escalation into a widespread health crisis.
Random Algebraic Graphs and Their Convergence to ErdőS–Rényi
Authors: Bangachev Kiril , Bresler Guy 
Published: January 2025

ABSTRACTA random algebraic graph is defined by a group with a uniform distribution over it and a connection with expectation satisfying . The random graph with vertex set is formed as follows. First, independent variables are sampled uniformly from . Then, vertices are connected with probability . This model captures random geometric graphs over the sphere, torus, and hypercube; certain instances of the stochastic block model; and random subgraphs of Cayley graphs. The main question of interest to the current paper is: when is a random algebraic graph statistically and/or computationally distinguishable from ? Our results fall into two categories. (1) Geometric. We focus on the case and use Fourier‐analytic tools. We match and extend the following results from the prior literature: For hard threshold connections, we match for , and for ‐Lipschitz connections we extend the results of when to the non‐monotone setting. (2) Algebraic. We provide evidence for an exponential statistical‐computational gap. Consider any finite group and let be a set of elements formed by including each set of the form independently with probability Let be the distribution of random graphs formed by taking a uniformly random induced subgraph of size of the Cayley graph . Then, and are statistically indistinguishable with high probability over if and only if . However, low‐degree polynomial tests fail to distinguish and with high probability over when
Mixing Cutoff for Simple Random Walks on the Chung–Lu Digraph
Authors: Bianchi Alessandra , Passuello Giacomo 
Published: January 2025

ABSTRACTIn this article, we are interested in the mixing behavior of simple random walks on inhomogeneous directed graphs. We focus our study on Chung–Lu digraphs, which are inhomogeneous networks that generalize Erdös–Rényi digraphs, and where edges are included independently and according to given Bernoulli laws. To guarantee that a unique equilibrium measure exists with high probability, we assume that the average degree grows logarithmically in the size of the graph. In this weakly sparse regime, we prove that the total variation distance to equilibrium displays a cutoff behavior at the entropic time of order . Moreover, we prove that on a precise window the cutoff profile converges to the Gaussian tail function. This is qualitatively similar to what was proved by Bordenave et al. and Cai et al. for the directed configuration model. In terms of statistical ensembles, our analysis provides an extension of these cutoff results from a hard to a soft‐constrained model.MSC2010 Classification: 60J10, 05C80, 05C81
Assessing the Potential of Gel–SA–MgHA Composite Biomaterial Ink for 3D Bioprinting Tracheal Stents
Authors: Wang Songquan , Lin Hao , Bo Yun , Dong Yudie , Cui Yuming , Li Haiquan , Hang Wenlu 
Published: January 2025

AbstractDiseases such as injury, stenosis, and tumors of the long trachea usually require the removal of the affected part of the trachea. There is an urgent need to implant tracheal stents as substitutes in clinical practice. In this paper, Mg2+ was first doped into hydroxyapatite (HA) matrix by hydrothermal synthesis and then mixed with gelatin sodium alginate (Gel–SA) double network crosslinked hydrogel to prepare gelatin sodium alginate magnesium doped hydroxyapatite (Gel–SA–MgHA) composite biomaterial ink. The trachea stent was prepared by 3D bioprinting technology and its physicochemical, mechanical, and biological properties were systematically evaluated. Due to the large number of hydrophilic groups on the surface of the HA matrix, the addition of MgHA improved the hydrophilicity of tracheal stents. The mechanical properties of the stent first increase and then decrease with the increase of MgHA content. When the MgHA content is 4 wt%, the tracheal stent has the optimal mechanical properties. In vitro cytology experiments have confirmed that the four stent materials have good cell compatibility and proliferation characteristics. Overall, Gel–SA–4MgHA has the best mechanical and cytological properties, and has certain potential in the clinical application of tracheal stents.
A Facile Route Through Iodine‐Mediated Synthesis of Isoxazole Derivatives from Chalcone Epoxide
Authors: Bhakta Avijit , Ahmed Naseem 
Published: January 2025

AbstractA novel synthetic route for the direct synthesis of 4,5‐diarylisoxazoles is less common. A facile and efficient synthesis of 4,5‐diarylisoxazole derivatives via I2‐mediated reaction from α,β‐chalcone epoxides under mild and metal‐free conditions is developed. This protocol enables facile access to 4,5‐diarylisoxazole derivatives in good to excellent yields using EtOH/H2O (1:1) solvent at 80 °C temperature. The structural integrity of the compounds was confirmed by 1H, 13C, IR, CHNS, GC‐MS, and SC‐XRD analysis.
Distribution of Fetal Nuchal Translucency Thickness in Normal Chinese Fetuses With Crown‐Rump Length of 45–80 mm
Authors: Tang Bin , Huang Yanlin , He Tianwen , Zhong Zhicheng , Li Jie , Chen Keyi 
Published: January 2025

ABSTRACTObjectiveThe primary aim of this research was to establish normative values for nuchal translucency (NT) thickness with crown‐rump length (CRL) ranging from 45 to 80 mm in a representative sample of the Chinese population.MethodsThe distributions of NT were derived for 24,892 unaffected fetuses with a CRL between 45 and 80 mm. The relationship between fetal NT thickness and CRL was assessed using linear regression analysis.ResultsThe regression equation describing the relationship between NT thickness and CRL was: NT thickness = 0.020 × CRL + 0.218, (R2 = 0.112, p < 0.001). The 50th percentile ranged from 1.12 to 1.82 mm and the 95th percentile ranged from 1.89 to 2.75 mm across 45–80 mm. The 95th percentile of NT MoM was 1.5375 over the CRL range of 45–80 mm.ConclusionsNormative values for NT thickness were established based on CRL measurements in a sample from the Chinese population. Due to physiological and ethnic variations in NT measurements, employing local CRL‐dependent cut‐offs for NT may offer advantages in anomaly screening during the first trimester of pregnancy compared to fixed cut‐off values.
PCM‐RF a Hybrid Feature Selection Mechanism for Intrusion Detection System in IoT
Authors: Ahmed Naveed , Ngadi Md Asri , Rathore Muhammad Siraj , Mahmood Azhar 
Published: January 2025

ABSTRACTThe integrity and security of data must be protected in the framework of the Internet of Things (IoT). This article addresses the difficulties presented by possible cyber threats to IoT devices by introducing a unique feature selection technique called Pearson correlation matrix with random forest (PCM‐RF). IoT device security is greatly influenced by machine learning techniques, which mostly depend on the caliber of characteristics taken from IoT datasets. By merging the advantages of RF with PCM, PCM‐RF maximizes feature selection and fine‐tunes features to improve the efficacy of current machine learning techniques and bolster classification algorithms' detecting powers. The study focuses on addressing limitations in existing ways of training and testing classification algorithms, which frequently lack strategies for optimizing and fine‐tuning features. Thirty‐four different forms of network assaults are included in the IoTCIC2023 dataset, used to assess PCM‐RF. Results demonstrate PCM‐RF's effectiveness, with XGBoost achieving an astounding accuracy of 99.39% and an 86% detection rate. Comparative studies highlight PCM‐RF's superiority in detection and classification results, offering insights into IoT security and emphasizing its potential to improve the overall device robustness in the IoT ecosystem.
Of “Employer Skills” and “Poetry”: Logics of New Arts and Humanities Programs
Authors: Hill Rob Loren 
Published: January 2025

ABSTRACTNeoliberalism is ubiquitous in higher education. In its dedication to efficiency and measurement, neoliberalism poses threats to the arts and humanities, especially their least measurable, most human qualities. Guided by an institutional logics framework, this multiple case study gauged how arts and humanities faculty can navigate this tension as they develop new academic majors and minors. Findings detail collaborative and top‐down decision‐making and the importance to faculty of supporting students and advancing academic fields. Faculty showed how they employed hybrid logics by striking balances and compartmentalizing actions. Their actions emphasized adaptations to neoliberalism while advancing academic and democratic logics.
Analytical and Numerical Solutions of Concentration With Deposition Under Unstable Condition
Authors: Essa Khaled S. M. , Said Sawsan E. M. El , Taha Hanaa. M. , Shalaby Ahmed S. 
Published: January 2025

ABSTRACTIn order to study the analytical and numerical solutions with Adomain decomposition of the pollutant's concentration from point source, wind speed and vertical turbulent eddy diffusivity are taken into account as functions of the vertical height above the surface layer power law. The top of the boundary layer of height has an elevated inversion layer that limits the concentration, and there is dry deposition on the ground surface. The pollutant's degradation distance is also estimated. The outcomes of the analytical and numerical solutions were compared with Iodine‐135 measured data under unstable conditions at the Egyptian Atomic Energy Authority. One finds that there is a better agreement between the predicted and observed concentrations than between the numerical concentrations. This study compares the analytical and numerical solutions of the advection‐diffusion equation and data of Iodine‐135 concentrations observed under unstable conditions.
Condensed‐Phase Quantum Chemistry
Authors: Robinson Paul J. , Rettig Adam , Dinh Hieu Q. , Chen Meng‐Fu , Lee Joonho 
Published: January 2025

ABSTRACTMolecular quantum chemistry has seen enormous progress in the last few decades thanks to more advanced and sophisticated numerical techniques and computing power. Following the recent interest in extending these capabilities to condensed‐phase problems, we summarize basic knowledge of condensed‐phase quantum chemistry for readers with experience in molecular quantum chemistry. We highlight recent efforts in this direction, including solving the electron repulsion integrals bottleneck, implementing hybrid density functional theory and wavefunction methods, and simulating lattice dynamics for periodic systems within atom‐centered basis sets. Many computational techniques presented here are inspired by the extensive method developments rooted in quantum chemistry. In this Focus Article, we selectively focus on the computational techniques rooted in molecular quantum chemistry, emphasize some challenges, and point out open questions. We hope our perspectives will encourage researchers to pursue this exciting and promising research avenue.
Double-stranded RNA orbivirus disrupts the DNA-sensing cGAS-sting axis to prevent type I IFN induction
Authors: Louloudes-Lázaro Andrés , Nogales-Altozano Pablo , Rojas José M. , Veloz Jeury , Carlón Ana B. , Van Rijn Piet A. , Martín Verónica , Fernández-Sesma Ana , Sevilla Noemí 
Published: January 2025

Abstract
Cyclic GMP-AMP synthase (cGAS) is a DNA sensing cellular receptor that induces IFN-I transcription in response to pathogen and host derived cytosolic DNA and can limit the replication of some RNA viruses. Some viruses have nonetheless evolved mechanisms to antagonize cGAS sensing. In this study, we evaluated the interaction between Bluetongue virus (BTV), the prototypical dsRNA virus of the Orbivirus genus and the Sedoreoviridae family, and cGAS. We found mitochondrial damage and DNA accumulation in the cytoplasm of infected cells. In addition, we show that BTV infection blocks DNA-induced IFN-I transcription and that virus infection prevents DNA sensing by inducing cGAS and STING degradation. We identify BTV-NS3 as the viral protein responsible for cGAS degradation, showing that NS3 physically interacts with cGAS and induces its degradation through an autophagy-dependent mechanism. Taken together, these findings identify for the first time a mechanism by which a dsRNA virus interferes with a DNA sensing pathway to evade the innate immune response.
Representation theory of topological full groups of étale groupoids and paradoxicality
Authors: Alekseev Vadim , Finn-Sell Martin 
Published: January 2025

Abstract
We provide a unified treatment of several results concerning full groups of ample groupoids and paradoxical decompositions attached to them. This includes a criterion for the full group of an ample groupoid being amenable as well as comparison of its orbit, Koopman and groupoid-left-regular representations. Besides that, we unify several recent results about paradoxicality in semigroups and groupoids, relating embeddings of Thompson’s group V into full groups of ample étale groupoids.