bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of overfeeding on the digestive efficiency, voluntary physical activity levels, and fecal characteristics and microbiota of adult cats
Authors: Opetz Danielle L , Oba Patricia M , Swanson Kelly S 
Published: September 2023

AbstractThe incidence of feline obesity continues to rise despite it being a preventable disease. There are many risks and health perturbations associated with obesity, with several of those impacting a pet’s quality of life, wellness, and longevity. Feline obesity is commonly studied, but most research has been focused on weight loss rather than weight gain. To our knowledge, feline studies have not examined the implications of overfeeding and weight gain on gastrointestinal transit time (GTT) nor the association it has with the fecal microbiota. Therefore, the objective of this study was to determine the effects of overfeeding and weight gain on apparent total tract digestibility (ATTD), GTT, blood hormones, serum metabolites, hematology, fecal microbiota populations, and voluntary physical activity of cats. Eleven lean adult spayed female cats [body weight (BW) = 4.11 ± 0.43 kg; body condition score = 5.41 ± 0.3; age = 5.22 ± 0.03 y] were used in a longitudinal weight gain study. After a 2-wk baseline phase, cats were allowed to overeat for 18 wk. A commercially available complete and balanced diet was fed during the baseline phase to identify the intake needed to maintain BW. Cats were then fed the same diet ad libitum to induce weight gain. Fecal samples, blood samples, and voluntary physical activity data were collected at baseline (week 0) and 6, 12, and 18 wk after weight gain. Fecal samples were collected for microbiota analysis, determination of ATTD, and GTT measurement while blood samples were collected for serum chemistry, hematology, and insulin and leptin measurements. Microbiota data were evaluated using QIIME2. All other measures were evaluated statistically using the mixed models procedure of SAS using repeated measures analysis, with time effects being the focus. A P &lt; 0.05 was considered significant. The ATTD of dry matter (P = 0.0061), organic matter (P = 0.0130), crude protein (P &lt; 0.0001), fat (P = 0.0002), and gross energy (P = 0.0002), and GTT (P = 0.0418) decreased with overfeeding and weight gain. Fecal bacterial alpha diversity measures were unchanged, but fecal bacterial beta diversity was impacted (P &lt; 0.05) with overfeeding and weight gain. The relative abundances of 16 bacterial genera, including Bifidobacterium, Collinsella, Erysipelatoclostridium were affected (P &lt; 0.05) by overfeeding and weight gain. In conclusion, overfeeding and subsequent weight gain reduced ATTD, reduced GTT, and caused changes to the fecal microbial community of adult cats.
Inhibition of human glutathione transferase by catechin and gossypol: comparative structural analysis by kinetic properties, molecular docking and their efficacy on the viability of human MCF-7 cells
Authors: Guneidy Rasha Awni , Zaki Eman Ragab , Saleh Nevein Salah-eldin , Shokeer Abeer 
Published: September 2023

Abstract
Glutathione transferase Pi (GSTP1) expression is increased in many cancer types and is associated with multidrug resistance and apoptosis inhibition. Inhibitors of GSTP1-1 have the potential to overcome drug resistance and improve chemotherapy efficacy as adjuvant agents. This study investigated the effects of catechin and gossypol on human glutathione transferase Pi (GSTP1-1) activity and their cytotoxic effects on breast cancer cells (MCF-7) individually and in combination with tamoxifen (TAM). Gossypol effectively inhibited the enzyme with an IC50 value of 40 μM, compared to 200 μM for catechin. Gossypol showed stronger inhibition of GSTP1-1 activity (Ki = 63.3 ± 17.5 μM) compared to catechin (Ki = 220 ± 44 μM). Molecular docking analysis revealed their binding conformations to GSTP1-1, with gossypol binding at the subunit interface in an un-competitive manner and catechin showing mixed non-competitive inhibition. Gossypol had severe cytotoxic effects on both MCF-7 cells and normal BJ1 cells, while catechin had a weak cytotoxic effect on MCF-7 cells only. Combination therapy with TAM resulted in cytotoxicity of 27.3% and 35.2% when combined with catechin and gossypol, respectively. Gossypol showed higher toxicity to MCF-7 cells, but its strong effects on normal cells raised concerns about selectivity and potential side effects.
Irritable Bowel Syndrome Patient Experience: A Survey of Patient-Reported Symptoms by Irritable Bowel Syndrome Subtype and Impact on Quality of Life
Authors: Bhinder Ganive , Meza-Cardona Javier M , Low Alan , Aumais Guy , Attara Gail P , Gray James R 
Published: September 2023

Abstract

Objectives
Irritable bowel syndrome (IBS) is a chronic, debilitating, functional gastrointestinal disorder with symptoms of abdominal pain, bloating, and altered bowel behaviours of constipation (IBS-C), diarrhea (IBS-D), or a mixture of both (IBS-M). There is limited information published on the impact of symptoms on everyday life in the Canadian population.

Methods
An online survey was conducted with individuals diagnosed with IBS to capture the severity and frequency of patient-reported symptoms, including impact on productivity, quality of life, healthcare utilization, treatment access, and corresponding symptom relief. Responses from the three subtypes of IBS were categorized to illustrate differences among these.

Results
There were 2,470 qualified respondents (filtered from 2,981, which included nonspecific IBS). IBS-M was the most common subtype, at 44 percent. Most individuals from all three IBS subtypes reported experiencing moderate to severe abdominal pain (63–70 percent) and bloating (59–75 percent) over the previous 3 months. Persons living with IBS-C reported severe bloating (32 percent), straining (72 percent), and tenesmus (78 percent) whereas those with IBS-D experienced severe urgency (63 percent) and incontinence (29 percent). Symptoms interfered in daily life, sometimes in 46 percent and often in 23 percent of respondents. Patients reported mood and anxiety disorders as common comorbidities with IBS (mood disorders: 30–34 percent; anxiety disorders: 25–30 percent).

Conclusions
This study focuses on the differences among the IBS subtypes. IBS impacts productivity and healthcare utilization, which requires further investigation on approaches to improve treatment. The frequency and severity of symptoms in IBS are high and only a few respondents reported that their symptoms are under control.
Trophic discrimination factors and stable isotope variability in a captive feeding trial of the southern rock lobster Jasus edwardsii () (Decapoda: Palinuridae) in Tasmania, Australia
Authors: Smith Jennifer E , Dietz Christian , Keane John , Mundy Craig , Oellermann Michael , Gardner Caleb 
Published: September 2023

Abstract
Trophic discrimination or fractionation factors (TDFs), such as ∆15N and ∆13C, are used in stable isotope mixing models to account for differences between source tissues (diet/prey) and consumer tissues (predator). We aimed firstly to obtain TDF values for a spiny lobster, the southern rock lobster Jasus edwardsii (Hutton, 1875), to better understand lobster diet in the wild and secondly to investigate variability in isotope signature within tissues of individuals and across a temporal scale to test if non-lethal sampling can be used in an ecological context. We conducted an 18-mo captive feeding trial with juvenile lobsters using three diet treatments and analysed dorsal and leg muscle, along with dorsal and leg exoskeleton for δ13C and δ15N values. Average TDFs for the three diet treatments were 3.86 ± 0.98‰ (∆13C) and 5.06 ± 0.65‰ (∆15N) for leg muscle, and 4.45 ± 1.04‰ (∆13C) and 4.36 ± 0.6‰ (∆15N) for dorsal muscle. When tested against wild lobsters and prey, these TDFs outperformed multi-taxa TDFs found in the literature. Isotope values from lobster leg muscle were not identical to associated dorsal muscle but the two were highly correlated, indicating that non-lethal sampling is acceptable. Values for exoskeleton isotope were significantly different from muscle, likely due to the exoskeleton not being in a constant state of growth and replacement, unlike the muscle tissue, which constantly incorporates new material. We conclude that our experimentally derived TDFs are suitable for mixing model analysis for J. edwardsii and when tested on a wild sample of lobsters they outperformed other TDFs reported in the literature. We show that non-lethal sampling using leg muscle is an appropriate sampling method, since this tissue is highly correlated to the commonly used dorsal muscle. This option for non-lethal sampling enhances the potential to widely sample wild populations or sample during industrial processing without the need to sacrifice whole animals.
Seasonal occurrence of bark and woodboring Coleoptera in stands of Pinus densiflora (Pinales: Pinaceae) and Larix kaempferi (Pinales: Pinaceae) and monitoring method using multifunnel traps baited with pine volatiles
Authors: Park Ji-Hong , Huh Min-Jung , Lee Jae-Woo , Lee Min-Woo , Lee Dong-Ho , Nam Il , Park Il-Kwon 
Published: September 2023

Abstract
This study investigated the seasonal occurrence of bark and woodboring Coleoptera in Pinus densiflora (Pinales: Pinaceae), and Larix kaempferi (Pinales: Pinaceae) stands using multifunnel traps baited with pine volatiles in Korea. The number and species of bark and woodboring beetles caught in traps baited with ethanol, α-pinene, and ethanol+α-pinene were compared to determine the effective attractants. In addition, the effects of other pine volatiles, such as (-)-β-pinene, β-caryophyllene, (±)-limonene, β-myrcene, and 3-carene, were investigated. A total of 13,134 woodboring beetles from 150 species were collected from pine and larch stands from 2019 to 2020. Tomicus minor (Hartig) (Coleoptera: Curculionidae) adults were more attracted to traps baited with α-pinene, whereas Xyleborinus saxesenii (Ratzeburg) (Coleoptera: Curculionidae), Cyclorhipidion pelliculosum (Eichhoff) (Coleoptera: Curculionidae), and Phloeosinus pulchellus (Blandford) (Coleoptera: Curculionidae) adults were more attracted to traps baited with ethanol. Hylurgops interstitialis (Chapuis) (Coleoptera: Curculionidae), Shirahoshizo genus group, Rhagium inquisitor (Linne) (Coleoptera: Cerambycidae), and Rhadinomerus maebarai (Voss & Chûjô) (Coleoptera: Curculionidae) were more frequently attracted to traps baited with ethanol+α-pinene than to traps baited with other attractants. The addition of 3-carene to ethanol+α-pinene enhanced the capture of H. interstitialis, R. inquisitor, and Hylobius (Callirus) haroldi (Faust) (Coleoptera: Curculionidae).
Crisp Bi-Gödel modal logic and its paraconsistent expansion
Authors: Bílková Marta , Frittella Sabine , Kozhemiachenko Daniil 
Published: September 2023

Abstract
In this paper, we provide a Hilbert-style axiomatization for the crisp bi-Gödel modal logic $\textbf {K}\textsf {biG}$. We prove its completeness w.r.t. crisp Kripke models where formulas at each state are evaluated over the standard bi-Gödel algebra on $[0,1]$. We also consider a paraconsistent expansion of $\textbf {K}\textsf {biG}$ with a De Morgan negation $\neg $, which we dub $\textbf {K}\textsf {G}^{2}$. We devise a Hilbert-style calculus for this logic and, as a consequence of a conservative translation from $\textbf {K}\textsf {biG}$ to $\textbf {K}\textsf {G}^{2}$, prove its completeness w.r.t. crisp Kripke models with two valuations over $[0,1]$ connected via $\neg $. For these two logics, we establish that their decidability and validity are $\textsf {PSPACE}$-complete. We also study the semantical properties of $\textbf {K}\textsf {biG}$ and $\textbf {K}\textsf {G}^{2}$. In particular, we show that Glivenko’s theorem holds only in finitely branching frames. We also explore the classes of formulas that define the same classes of frames both in $\textbf {K}$ (the classical modal logic) and the crisp Gödel modal logic $\mathfrak {G}\mathfrak {K}^{c}$. We show that, among others, all Sahlqvist formulas and all formulas $\phi \rightarrow \chi $ where $\phi $ and $\chi $ are monotone define the same classes of frames in $\textbf {K}$ and $\mathfrak {G}\mathfrak {K}^{c}$.
Meet Amblyseius swirskii (Acari: Phytoseiidae): a commonly used predatory mite in vegetable crops
Authors: Lopez Lorena 
Published: September 2023

Abstract
The predatory mite, Amblyseius swirskii Athias-Henriot (Acari: Phytoseiidae), is a generalist predator feeding on multiple soft-bodied insects and mite pest species. It is a biological control agent commercially available since 2005 that has become one of the top 3 most released biocontrol predators worldwide. It is commonly used to suppress whitefly populations (Hemiptera: Aleyrodidae), thrips (Thysanoptera), and spider mites (Acari: Tetranychidae) to a lesser degree. This predatory mite has been used as part of Integrated Pest Management (IPM) programs for vegetable (e.g., peppers, eggplants, cucumbers, squash) and ornamental (e.g., roses, chrysanthemums) crops in open fields and greenhouses, and some field crops such as cotton, but it has been demonstrated to be more successful at establishing reproductive populations and suppressing pests under protected structures. Amblyseius swirskii can feed on various food resources besides prey, including pollen or honeydew. It is successful at suppressing pests when used together with low-risk pesticides, when multiple prey are available, when prey and pollen are available naturally (neighboring flowering or companion plants present), or when pollen is supplemented in the field. This predator is a good option to control pests early in the season if shelter and food resources are available for its establishment.
GKT137831 in combination with adipose-derived stem cells alleviates high glucose–induced inflammaging and improves diabetic wound healing
Authors: Dong Yunxian , Zhang Youliang , Li Fangwei , Tang Bing , Lv Dongming , Wang Haibin , Luo Shengkang 
Published: September 2023

Abstract
Adipose-derived stem cells (ADSCs) have been proven to promote healing in diabetic wounds, which are one of the most serious chronic refractory wounds. However, reactive oxygen species (ROS) induced by high glucose (HG) lead to oxidative stress and aging in ADSCs, which limits the therapeutic effect of ADSCs. In this study, we investigated the role of GKT137831, a NOX1/4 inhibitor that can reduce ROS production, in protecting ADSCs from hyperglycemia and in diabetic wound healing. In vitro, ROS levels and NOX4 expression were increased after HG treatment of ADSCs, while the oxidative stress marker malondialdehyde was increased; mitochondrial membrane potential was decreased; inflammatory aging–related indicators such as p16, p21, matrix metalloproteinase-1 (MMP1), MMP3, interleukin-6, and β-galactosidase were increased; and migration was weakened. In vivo, we constructed a diabetic mouse wound model and found that the combination of ADSCs and GKT137831 synergistically promoted the 21-day wound healing rate, increased the expression of collagen and hydroxyproline, increased the number of blood vessels and the expression of CD31, and reduced the expression of interleukin-6, MMP1, MMP3, and p21. These results suggest that GKT137831 could protect ADSCs from oxidative stress and aging induced by HG and enhance the therapeutic effect of ADSCs on diabetic wounds.
Adjuvant chemotherapy benefit according to T and N stage in small bowel adenocarcinoma: a large retrospective multicenter study
Authors: Zaanan Aziz , Henriques Julie , Turpin Anthony , Manfredi Sylvain , Coriat Romain , Terrebonne Eric , Legoux Jean-Louis , Walter Thomas , Locher Christophe , Dubreuil Olivier , Pernot Simon , Vernet Chloé , Bouché Olivier , Hautefeuille Vincent , Gagniere Johan , Lecomte Thierry , Tougeron David , Grainville Thomas , Vernerey Dewi , Afchain Pauline , Aparicio Thomas 
Published: September 2023

Abstract

Background
Small bowel adenocarcinoma is a rare cancer, and the role of adjuvant chemotherapy for localized disease is still debated.

Methods
This retrospective multicenter study included all consecutive patients who underwent curative surgical resection for localized small bowel adenocarcinoma between 1996 and 2019 from 3 French cohort studies. Prognostic and predictive factors of adjuvant chemotherapy efficacy were analyzed for disease-free survival and overall survival. The inverse probability of treatment weighting method was applied in the Cox regression model using the propensity score derived from multivariable logistic regression.

Results
A total of 354 patients were included: median age, 63.5 years; duodenum location, 53.5%; and tumor stage I, II, and III in 31 (8.7%), 144 (40.7%), and 179 (50.6%) patients, respectively. The adjuvant chemotherapy was administered in 0 (0%), 66 (48.5%), and 143 (80.3%) patients with stage I, II, and III, respectively (P &lt; .0001). In the subgroup analysis by inverse probability of treatment weighting method, a statistically significant disease-free survival and overall survival benefit in favor of adjuvant chemotherapy was observed in high-risk stage II (T4 and/or &lt;8 lymph nodes examined) and III (T4 and/or N2) but not for low-risk stage II (T3 and ≥8 lymph nodes examined) and III (T1-3/N1) tumors (Pinteraction &lt; .05). Furthermore, tumor location in jejunum and ileum was also a statistically significant predictive factor of response to adjuvant chemotherapy in stage II and III tumors (Pinteraction &lt; .05).

Conclusion
In localized small bowel adenocarcinoma, adjuvant chemotherapy seems to provide a statistically significant survival benefit for high-risk stage II and III tumors and for jejunum and ileum tumor locations.
An optimized transient detection pipeline for the ASKAP Variables and Slow Transients (VAST) survey
Authors: An Tao , Lao Baoqiang , Xu Zhijun , Lu Shuoying , Wang Yuanming , Murphy Tara , Kaplan David L , Guo Shaoguang 
Published: September 2023

ABSTRACT
In this paper, we present an optimized version of the detection pipeline for the ASKAP Variables and Slow Transients (VAST) survey, offering significant performance improvement. The key to this optimization is the replacement of the original w-projection algorithm integrated in the Common Astronomy Software Applications package with the w-stacking algorithm implemented in the WSClean software. Our experiments demonstrate that this optimization improves the overall processing efficiency of the pipeline by approximately a factor of 3. Moreover, the residual images generated by the optimized pipeline exhibit lower noise levels and fewer artefact sources, suggesting that our optimized pipeline not only enhances detection accuracy but also improves imaging fidelity. This optimized VAST detection pipeline is integrated into the Data Activated Liu Graph Engine (DALiuGE) execution framework, specifically designed for SKA-scale big data processing. Experimental results show that the performance and scalability advantages of the pipeline using DALiuGE over traditional MPI or BASH techniques increase with the data size. In summary, the optimized transient detection pipeline significantly reduces runtime, increases operational efficiency, and decreases implementation costs, offering a practical optimization solution for other ASKAP imaging pipelines as well.
Particle-in-cell simulations – ion beam instabilities and the generation of Alfvén and whistler waves in low β plasma
Authors: Che H , Benz A O , Zank G P 
Published: September 2023

ABSTRACT
Ion beam-driven instabilities in a collisionless space plasma with low β, i.e. low plasma and magnetic pressure ratio, are investigated using particle-in-cell (PIC) simulations. Specifically, the effects of different ion drift velocities on the development of Buneman and resonant electromagnetic (EM) right-handed (RH) ion beam instabilities are studied. Our simulations reveal that both instabilities can be driven when the ion beam drift exceeds the theoretical thresholds. The Buneman instability, which is weakly triggered initially, dissipates only a small fraction of the kinetic energy of the ion beam while causing significant electron heating, owing to the small electron-ion mass ratio. However, we find that the ion beam-driven Buneman instability is quenched effectively by the resonant EM RH ion beam instability. Instead, the resonant EM RH ion beam instability dominates when the ion drift velocity is larger than the Alfvén speed, leading to the generation of RH Alfvén waves and RH whistler waves. We find that the intensity of Alfvén waves decreases with decrease of ion beam drift velocity, while the intensity of whistler waves increases. Our results provide new insights into the complex interplay between ion beams and plasma instabilities in low β collisionless space plasmas.
Extending the unified subhalo model to warm dark matter
Authors: He Feihong , Han Jiaxin , Gao Hongyu , Zhang Jiajun 
Published: September 2023

ABSTRACT
Using a set of high-resolution N-body simulations, we extend the unified distribution model of cold dark matter (CDM) subhaloes to the warm dark matter (WDM) case. The same model framework combining the unevolved mass function, unevolved radial distribution, and tidal stripping can predict the mass function and spatial distribution of subhaloes in both CDM and WDM simulations. The dependence of the model on the DM particle property is universally parametrized through the half-mode mass of the initial power spectrum. Compared with the CDM model, the WDM model differs most notably in two aspects. (1) In contrast to the power-law form in CDM, the unevolved subhalo mass function for WDM is scale-dependent at the low mass end due to the cut-off in the initial power spectrum. (2) WDM subhaloes are more vulnerable to tidal stripping and disruption due to their lower concentrations at accretion time. Their survival rate is also found to depend on the infall mass. Accounting for these differences, the model predicts a final WDM subhalo mass function that is also proportional to the unevolved subhalo mass function. The radial distribution of WDM subhaloes is predicted to be mass-dependent. For low mass subhaloes, the radial distribution is flatter in the inner halo and steeper in the outer halo compared to the CDM counterpart, due to the scale-dependent unevolved mass function and the enhanced tidal stripping. The code for sampling subhaloes according to our generalized model is available at https://github.com/fhtouma/subgen2.
Quasi-regular variations of subpulse drifting for PSR J1857+0057
Authors: Yan Yi , Han J L , Wang C , Wang P F 
Published: September 2023

ABSTRACT
During observations of the Galactic Plane Pulsar Snapshot survey by the Five-hundred-meter Aperture Spherical radio Telescope, varying subpulse drifting of PSR J1857+0057 is detected. The follow-up observation confirms the quasi-regular changes of the drifting rate about every 50 periods. We determine the drift rate D through a linear fit to the pulse-central longitudes of subpulses in a drifting band, and determine P3 from the cross-points of two fitted lines at the zero longitude for two neighbouring drifting bands. The low frequency modulation of about every 50 periods is found on variations of not only pulse intensity but also drift parameters. In most of low frequency modulation cycles, the integrated pulse intensity I and the absolute drift rate |D| tend to increase first and then decrease, and the drifting periodicity P3 varies just in the opposite. In addition, the phase-forward intensity-enhancement is observed in many modulation cycles. Based on our polarization data, the average position angle curve for pulses with a smaller |D| and larger P3 is slightly steep in the leading edge of pulse profile compared with that of the fully averaged profile.