bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between hypoproteinaemia with massive proteinuria and small for gestational age in pre-eclampsia: a single-centre, retrospective cohort study using propensity score matching
Authors: Lv Yanxiang , Zhou Ying , Hu Rui , Liang Yan , Lian Yanan , Wang Jun , Wei Yang , Zhang Yanmei , Qiao Yuan , He Tongqiang 
Published: July 2023

ObjectiveTo investigate the association between hypoproteinaemia with massive proteinuria and the incidence of small for gestational age in pre-eclampsia.DesignRetrospective cohort study using propensity score matching.SettingNorthwest Women’s and Children’s Hospital in Shaanxi Province, China, using data from January 2016 to December 2021.ParticipantsPatients diagnosed with pre-eclampsia were grouped into the massive proteinuria group if the maximum proteinuria was >3.5 g/day and the minimum serum albumin was <30 g/L; otherwise, they were placed in the control group.Outcome measuresThe primary outcome was the incidence of small for gestational age infants. Secondary outcomes included fetal death, admission to the neonatal intensive care unit, a 5 min APGAR score <7, severe small for gestational age, fetal growth restriction, birth weight, premature birth, and maternal outcomes such as eclampsia, encephalopathy, placental abruption, haemolysis, elevated liver enzymes and low platelet syndrome, heart failure and retinal detachment.ResultsIn total, 468 patients (234 from each group) were included, and the groups were well matched. The incidences of small for gestational age (33.76% vs 20.51%, OR 1.646, 95% CI 1.208 to 2.243, p=0.001), severe small for gestational age (14.70% vs 7.69%, OR 1.833, 95% CI 1.063 to 3.162, p=0.026), fetal growth restriction (23.93% vs 16.24%, OR 1.474, 95% CI 1.018 to 2.133, p=0.038), and the numbers of infants admitted to the neonatal intensive care unit (67.52% vs 58.55%, OR 1.153, 95% CI 1.003 to 1.326, p=0.044) were significantly higher in patients with hypoproteinaemia and massive proteinuria than in the control group. In addition, the median birth weight was significantly lower in the massive proteinuria group. There were no significant differences in maternal outcomes except for renal parameters, which were worse in the massive proteinuria group.ConclusionHypoproteinaemia with massive proteinuria was associated with fetal growth and a higher incidence of small for gestational age infants in pre-eclampsia.
Cannabis use among workers with work-related injuries and illnesses: results from a cross-sectional study of workers’ compensation claimants in Ontario, Canada
Authors: Carnide Nancy , Nadalin Victoria , Mustard Cameron , Severin Colette N , Furlan Andrea D , Smith Peter M 
Published: July 2023

ObjectivesLittle is known about how workers use cannabis following a work-related injury/illness, including whether they receive clinical guidance. The objective was to compare characteristics of workers using and not using cannabis after a work-related injury/illness and describe use patterns.DesignCross-sectional study.Setting and participantsWorkers who experienced a work-related physical injury/illness resulting in one or more days of lost time compensated by the workers’ compensation authority in Ontario, Canada (n=1196).MethodsParticipants were interviewed 18 or 36 months after their injury/illness. Participants were asked about their past-year cannabis use, including whether use was for the treatment of their work-related condition. Sociodemographic, work and health characteristics were compared across cannabis groups: no past-year use; use for the work-related condition; use unrelated to the work-related condition. Cannabis use reasons, patterns, perceived impact and healthcare provider engagement were described.ResultsIn total, 27.4% of the sample reported using cannabis (14.1% for their work-related condition). Workers using cannabis for their condition were less likely to be working (58.0%) and more likely to have quite a bit/extreme pain interference (48.5%), psychological distress (26.0%) and sleep problems most/all the time (62.1%) compared with those not using cannabis (74.3%, 26.3%, 12.0% and 38.0%, respectively) and those using cannabis for other reasons (74.2%, 19.5%, 12.0% and 37.1%, respectively) (all p<0.0001). No significant differences were observed in medical authorisations for use among those using cannabis for their condition (20.4%) or unrelated to their condition (15.7%) (p=0.3021). Healthcare provider guidance was more common among those using cannabis for their condition (32.7%) compared with those using for other reasons (17.1%) (p=0.0024); however, two-thirds of this group did not receive guidance.ConclusionsCannabis may be used to manage the consequences of work-related injuries/illnesses, yet most do not receive clinical guidance. It is important that healthcare providers speak with injured workers about their cannabis use.
Pan-Canadian study of psychiatric care (PCPC): protocol for a mixed-methods study
Authors: Rudoler David , Lavergne M Ruth , Marshall Emily Gard , Zaheer Juveria , Etches Selene , Good Kimberley P , Grudniewicz Agnes , Katz Alan , Kurdyak Paul , Bolton James , Kaoser Ridhwana , Moravac Catherine , Morrison Jason , Mulsant Benoit , Peterson Sandra , Tibbo Phil G 
Published: July 2023

IntroductionThe Canadian population has poor and inequitable access to psychiatric care despite a steady per-capita supply of psychiatrists in most provinces. There is some quantitative evidence that practice style and characteristics vary substantially among psychiatrists. However, how this compares across jurisdictions and implications for workforce planning require further study. A qualitative exploration of psychiatrists’ preferences for practice style and the practice choices that result is also lacking. The goal of this study is to inform psychiatrist workforce planning to improve access to psychiatric care by: (1) developing and evaluating comparable indicators of supply of psychiatric care across provinces, (2) analysing variations and changes in the characteristics of the psychiatrist workforce, including demographics and practice style and (3) studying psychiatrist practice choices and intentions, and the factors that lead to these choices.Methods and analysisA cross-provincial mixed-methods study will be conducted in the Canadian provinces of British Columbia, Manitoba, Ontario and Nova Scotia. We will analyse linked-health administrative data within three of the four provinces to develop comparable indicators of supply and characterise psychiatric services at the regional level within provinces. We will use latent profile analysis to estimate the probability that a psychiatrist is in a particular practice style and map the geographical distribution of psychiatrist practices overlayed with measures of need for psychiatric care. We will also conduct in-depth, semistructured qualitative interviews with psychiatrists in each province to explore their preferences and practice choices and to inform workforce planning.Ethics and disseminationThis study was approved by Ontario Tech University Research Ethics Board (16637 and 16795) and institutions affiliated with the study team. We built a team comprising experienced researchers, psychiatrists, medical educators and policymakers in mental health services and workforce planning to disseminate knowledge that will support effective human resource policies to improve access to psychiatric care in Canada.
Assessment of knowledge, attitudes and practices towards COVID-19 among rural adolescents in Thakurgaon district, Bangladesh: an interview-based study
Authors: Hossain Md Sobuj , Banik Rajon , Hosen Ismail , Islam Md Zohurul , Kundu Lakshmi Rani 
Published: July 2023

ObjectivesTo evaluate the understanding, opinions and actions concerning COVID-19, referred to as knowledge, attitudes and practices (KAP), among rural adolescents in Bangladesh. Additionally, the study aimed to identify the determinants that may influence adolescents’ KAP.DesignAn interview-based cross-sectional study.SettingThe study area was the Thakurgaon district, which was located in the northwestern region of Bangladesh.ParticipantsA total of 266 rural adolescents were selected using a non-probability (convenience sampling) technique.Main outcome measuresSociodemographic characteristics, source of information, COVID-19-related KAP, and their associated factors.ResultsThe majority of the respondents were females and reported that mass media (eg, television channels and papers) was the main source of information to learn about COVID-19. The mean score for knowledge was 7.15±3, whereas the scores were 10.5±2.8, and 8.78±2.66 for attitude and practice, respectively. Among the adolescents, only 11% had adequate knowledge, a positive attitude (27%) and good practices (31%). The predictive factors related to adolescents' knowledge and attitude were their religion, educational level and family income. Adolescents who were from the Islamic religion and who had secondary education were more knowledgeable and encompassed more positive attitudes. Besides, poor KAP towards COVID-19 was significantly higher among the participants with the lowest family income (less than 10 000 BDT). Moreover, their knowledge was significantly associated with their attitudes and practices.ConclusionThe study found that adolescents in rural areas lacked sufficient knowledge of COVID-19 and engaged in unsatisfactory preventative behaviour. Therefore, the development of effective health education programmes that incorporate consideration of KAP-modifying factors is needed. In addition, the result would be helpful for other similar types of pandemics.
Imaging Neuroscience opening
editorial
Authors: Smith Stephen , Bergmann Til Ole , Forstmann Birte , Dagher Alain , Keilholz Shella , Kennedy Kristen , Kotz Sonja A. , Lustig Cindy , Pike Bruce , Tittgemeyer Marc , Woolrich Mark , Yeo B.T. Thomas , Alexander Andrew , Bijsterbosch Janine , Boonstra Tjeerd , Chakravarty Mallar , Chambers Chris , Chang Catie , Christian Bradley , Dalal Sarang S. , Ding Nai , Duarte Audrey , Fan Audrey P. , Gramfort Alexandre , Hartwigsen Gesa , Jabbi Mbemba , Kochunov Peter , Krämer Ulrike , Lindquist Martin , Mangin Jean-Francois , Murphy Kevin , Polimeni Jonathan , Robinson Emma , Rosenberg Monica , Sadaghiani Sepideh , Seghier Mohamed , Shih Yen-Yu Ian , Thielscher Axel , Uddin Lucina Q. , Van De Ville Dimitri , Vanduffel Wim , Yan Chao-Gan , Yendiki Anastasia 
Published: July 2023

Abstract
In this editorial we introduce a new non-profit open access journal, Imaging Neuroscience. In April 2023, editors of the journals NeuroImage and NeuroImage:Reports resigned, and a month later launched Imaging Neuroscience. NeuroImage had long been the leading journal in the field of neuroimaging. While the move to fully open access in 2020 represented a positive step toward modern academic practices, the publication fee was set to a level that the editors found unethical and unsustainable. The publisher of NeuroImage, Elsevier, was unwilling to reduce the fee after much discussion. This led us to launch Imaging Neuroscience with MIT Press, intended to replace NeuroImage as our field’s leading journal, but with greater control by the neuroimaging academic community over publication fees and adoption of modern and ethical publishing practices.
A robust quality infrastructure is key to safe and effective delivery of immune effector cells: how FACT-finding can help
Authors: Curran Kevin J. , Nikiforow Sarah , Bachier Carlos , Hsu Yen-Michael , Maloney David , Maus Marcela V. , McCarthy Philip , Porter David , Shi Patricia , Shpall Elizabeth J. , William Basem , Wacker Kara , Warkentin Phyllis , Heslop Helen E. 
Published: July 2023

Abstract
Immune effector cells (IECs) include a broad range of immune cells capable of modulating several disease states, including malignant and nonmalignant conditions. The growth in the use of IECs as both investigational and commercially available products requires medical institutions to develop workflows/processes to safely implement and deliver transformative therapy. Adding to the complexity of this therapy are the variety of targets, diseases, sources, and unique toxicities that a patient experiences following IEC therapy. For over 25 years, the Foundation for the Accreditation of Cellular Therapy (FACT) has established a standard for the use of cellular therapy, initially with hematopoietic cell transplantation (HCT), and more recently, with the development of standards to encompass IEC products such as chimeric antigen receptor (CAR)-T cells. To date, IEC therapy has challenged the bandwidth and infrastructure of the institutions offering this therapy. To address these challenges, FACT has established a programmatic framework to improve the delivery of IEC therapy. In this study, we outline the current state of IEC program development, accreditation, and solutions to the challenges that programs face as they expand their application to novel IEC therapy.
Multi-Round versus Real-Time Delphi survey approach for achieving consensus in the COHESION core outcome set: a randomised trial
Authors: Quirke Fiona A. , Battin Malcolm R. , Bernard Caitlin , Biesty Linda , Bloomfield Frank H. , Daly Mandy , Finucane Elaine , Haas David M. , Healy Patricia , Hurley Tim , Koskei Sarah , Meher Shireen , Molloy Eleanor J. , Niaz Maira , Bhraonáin Elaine Ní , Okaronon Christabell Omukagah , Tabassum Farhana , Walker Karen , Webbe James R. H. , Parkes Matthew J. , Kirkham Jamie J. , Devane Declan 
Published: July 2023

Abstract
Background
Delphi surveys are commonly used to prioritise critical outcomes in core outcome set (COS) development. This trial aims to compare a three-round (Multi-Round) Delphi (MRD) with a Real-Time Delphi (RTD) in the prioritisation of outcomes for inclusion in a COS for neonatal encephalopathy treatments and explore whether ‘feedback’, ‘iteration’, and ‘initial condition’ effects may occur in the two survey methods.

Methods
We recruited 269 participants (parents/caregivers, healthcare providers and researchers/academics) of which 222 were randomised to either the MRD or the RTD. We investigated the outcomes prioritised in each survey and the ‘feedback’, ‘iteration’, and ‘initial condition’ effects to identify differences between the two survey methods.

Results
In the RTD, n = 92 participants (83%) fully completed the survey. In the MRD, n = 60 participants (54%) completed all three rounds. Of the 92 outcomes presented, 26 (28%) were prioritised differently between the RTD and MRD. Significantly fewer participants amended their scores when shown stakeholder responses in the RTD compared to the MRD (‘feedback effect’). The ‘iteration effect’ analysis found most experts appeared satisfied with their initial ratings in the RTD and did not amend their scores following stakeholder response feedback. Where they did amend their scores, ratings were amended substantially, suggesting greater convergence. Variance in scores reduced with subsequent rounds of the MRD (‘iteration effect’). Whilst most participants did not change their initial scores in the RTD, of those that did, later recruits tended to align their final score more closely to the group mean final score than earlier recruits (an ‘initial condition’ effect).

Conclusion
The feedback effect differed between the two Delphi methods but the magnitude of this difference was small and likely due to the large number of observations rather than because of a meaningfully large difference. It did not appear to be advantageous to require participants to engage in three rounds of a survey due to the low change in scores. Larger drop-out through successive rounds in the MRD, together with a lesser convergence of scores and longer time to completion, indicate considerable benefits of the RTD approach.

Trial registration
NCT04471103. Registered on 14 July 2020.
Identification of potential biomarkers related to mesenchymal stem cell response in patients with Alzheimer’s disease
Authors: Choi Yejoo , Shin Sungho , Son Hyo Jin , Lee Na-Hee , Myeong Su Hyeon , Lee Cheolju , Jang Hyemin , Choi Soo Jin , Kim Hee Jin , Na Duk L. 
Published: July 2023

Abstract
Background
Preclinical studies showed that mesenchymal stem cells (MSCs) ameliorate tau phosphorylation, amyloid-beta accumulation, and inflammation in Alzheimer’s disease (AD) mouse models via secretion of neurotrophic factors and cytokines. We aimed to identify CSF biomarkers that can be used to predict or monitor the response to MSCs in patients with AD.

Methods
AD patients were injected with human umbilical cord blood-MSCs (n = 22) or placebo (n = 12). The cerebrospinal fluid (CSF) samples were collected at baseline, one day after the first injection, and one day after the third injection. The patients injected with MSCs were classified into good responder (GR) or poor responder (PR) groups based on the rate of changes in the ratio of total-tau and phosphorylated-tau in the CSF. We selected three typical participants in each group, and their CSF protein levels were analyzed using liquid chromatography/tandem mass spectrometry (LC–MS/MS).

Results
In the LC–MS/MS analysis, 1,667 proteins were identified. Eleven proteins showed significant differences between the typical GR and PR at baseline. Based on their significance level and known functions, two proteins, reticulocalbin-3 (RCN3) and follistatin-related protein 3 (FSTL3), were selected as potential biomarkers to predict MSC response. A total of 173 proteins showed significant change one day after the third injection compared to the baseline in typical GR. We excluded 45 proteins that showed significant change after the third injection compared to the baseline in the typical PR. Based on their significance level and known function, four proteins, scrapie-responsive protein 1 (SCRG1), neural proliferation differentiation and control protein (NPDC1), apolipoprotein E (ApoE), and cystatin C (CysC), were selected as potential biomarker to monitor MSC response. Additionally, functional analysis revealed that the increased CSF proteins after the third injection compared to the baseline in the typical GR were associated with synaptogenesis.

Conclusions
This study identified two proteins (RCN3 and FSTL3) that may be potential biomarkers for predicting MSC response and four proteins (SCRG1, NPDC1, ApoE, CysC) that may be potential biomarkers for monitoring MSC response in patients with AD. Further studies are needed to validate our results.
Trial registration Clinical Trials.gov, NCT02054208. Registered on 4 February 2014. Samsung Medical Center IRB File No.2017-04-025. Registered on 20 June 2017.
Chemical screening links disulfiram with cardiac protection after ischemic injury
Authors: Chen Yuanyuan , Du Jianyong , Zheng Lixia , Wang Zihao , Zhang Zongwang , Wu Zhengyuan , Zhu Xiaojun , Xiong Jing-Wei 
Published: July 2023

AbstractIschemia–reperfusion injury occurs after reperfusion treatment for patients suffering myocardial infarction, however the underlying mechanisms are incompletely understood and effective pharmacological interventions are limited. Here, we report the identification and characterization of the FDA-approved drug disulfiram (DSF) as a cardioprotective compound. By applying high-throughput chemical screening, we found that DSF decreased H2O2-induced cardiomyocyte death by inhibiting Gasdermin D, but not ALDH1, in cardiomyocytes. Oral gavage of DSF decreased myocardial infarct size and improved heart function after myocardial ischemia–reperfusion injury in rats. Therefore, this work reveals DSF as a potential therapeutic compound for the treatment of ischemic heart disease.
Antifungal activity of three different varieties of Capsicum annuum against clinical isolates of Candida species
Authors: Moghadam Shaghayegh , Azari Behnam , Rashidi Roghayeh , Bafghi Mahdi Hosseini , Rakhshandeh Hassan , Selman Selman Mohammed , Zarrinfar Hossein 
Published: July 2023

Abstract
Objective
Acquired resistance to antifungal agents is rising among Candida species. Herbal extracts including Capsicum annum extracts have biological profits, which can be employed to overcome drug resistance in fungal species. The present study investigated the efficacy of different varieties of C. annum extracts against Candida species.

Methods
Aqueous and alcoholic extracts of three different varieties of C. annum were prepared using the succulent method. Total values for compound extracts of C. annum var. cayenne, C. annum var. cayenne cultivar sabzevari, and C. annum var. cerasiforme were 43, 42, and 38 g, respectively. The clinical Candida isolates including C. albicans (n = 13), C. dubliniensis (n = 2), C. parapsilosis (n = 2), and C. tropicalis (n = 1); and reference strains of C. albicans (TIMML 1292 and TIMML 183), C. krusei (TIMML 1321), C. parapsilosis (TIMML 2201), and C. tropicalis (TIMML 731) were examined based on the M27-A3 guideline.

Results
Aqueous and alcoholic extracts of Capsicum annum showed a minimum inhibitory concentration (MIC) range of more than 512 µg/ml against clinical and reference strains of Candida. There was no justifiable difference between the effects of these extracts on Candida species.

Conclusion
Both aqueous and alcoholic extracts of Capsicum annum could not exert a significant effective impact on clinical and reference strains of Candida. The difference in pepper spiciness did not show a significant role against Candida isolates. However, their possible effects might be different among other yeasts or filamentous fungi.
Designing a survey framework to collect port stakeholders’ insight regarding AI implementation: results from the Flemish context
Authors: Farzadmehr Mehran , Carlan Valentin , Vanelslander Thierry 
Published: July 2023

AbstractToday, several research/initiatives exist in AI technology at the port operation. They mainly focus on solution development in a particular port and shipping industry domain. This scattered implementation leads to an unstructured overview of the port sector regarding AI innovation in use. Equally, this study aims to structure this overview for aligning stakeholders and AI providers toward implementation. In doing so, the first step would be collecting the port stakeholders' insight regarding AI implementation. This study develops a structured framework to collect the port stakeholders’ insight through both desk and empirical research. Besides, an online survey is built based on the framework and sent to a target group of port stakeholders to collect their insight. The survey results show that a huge effort is needed to establish a structure for data exchange to increase the quality of data. Additionally, by highlighting the importance of data from specific stakeholders, developers can effectively convey the value proposition to these stakeholders. They can emphasize how utilizing this vital data can result in operational enhancements, cost reductions, improved decision-making, and competitive advantages. As an implication, alignment between port stakeholders and AI providers enhances the maturity level of the market in AI solutions by fostering collaboration, addressing industry-specific challenges, tailoring solutions, and garnering support for implementation.