bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mastery-Oriented Students Are Less Stubborn
Authors: Romero Miriam , Hernández José Manuel , Juola James F. , Casadevante Cristina , Santacreu José 
Published: May 2023

AbstractGoal orientation theory identifies
mastery-oriented people as adaptive and highly persistent when pursuing a goal. Performance-oriented people are described as being less persistent, and tend to show more maladaptive responses. However, previous works that have studied persistence have not always found that performance-oriented participants show the least persistence. In addition, it is not easy to conclude if the persistence measured in the studies implies a stubborn response and therefore if it is a maladaptive response. In this work, we classify participants as mastery- or performance-oriented using an objective test and we employ a behavioral task to study persistence defined as stubbornness. When studying response patterns, we found that performance-oriented students were more stubborn. The behavioral analysis performed in this work offers complement and rich information and provides empirical support for the goal orientation theory.
An empirical analysis of the impact of semiconductor engineer characteristics on outflows and inflows: evidence from six major semiconductor countries
Authors: Fujiwara Ayano 
Published: May 2023

AbstractThe impact of cross-border migration of semiconductor engineers has become an important concern for many countries’ economic policies. There has been limited large-scale data analysis regarding the movement of semiconductor engineers between countries. This study creates an original engineer database for six major semiconductor countries (U.S., China, Taiwan, Japan, Korea, and Germany) using bibliographic information on patents and papers to analyze their transnational migration. Multiple logistic analysis is conducted on the impact of engineers’ characteristics such as age, skills, and areas of expertise on outflows and inflows. The analysis reveals that (1) the United States, Taiwan, Japan, and Germany have excess outflows of engineers, while China and South Korea have excess inflows, (2) the movement of engineers between the United States and China is the most frequent, and (3) there is a significant outflow of engineers from semiconductor fields in which each country specializes.
Measurement of quality of recovery using the postoperative quality of recovery scale (PQRS) in patients undergoing laparoscopic cholecystectomy: A prospective cohort pilot study
Authors: Vu Phan Ton Ngoc , Bang Ho Tat , Hieu Huynh Huu , Chinh Le Hong 
Published: May 2023

Abstract

Objectives
Quality of post-operative recovery is an essential end-point for evaluating anesthesia and surgery. Measures must incorporate patient-reported outcomes and satisfaction in addition to physiological indicators of recovery in order to fully assess the effects of anesthesia and surgery. This study is to explore the quality of recovery using the postoperative quality of recovery scale (PQRS) in patients undergoing laparoscopic cholecystectomy.

Methods
This is a single-center, prospective cohort pilot study. Patients undergoing laparoscopic cholecystectomy were divided into two groups: Group D with deep neuromuscular blockade and Group M with moderate neuromuscular blockade. After surgery, patients were assessed by using Post-operative Quality Recovery Scale (PQRS).

Results
60 patients in group D and 60 patients in group M were analyzed. The proportion of patients with excellent surgical conditions in group D was higher than in group M. In the recovery room, at 15 min and 40 min after endotracheal extubation, the recovery of the physiological domain in group D was significantly higher than in group M. In postoperative day 1, the overall recovery percentage was 78.3% in group D and 76.7% in group M.

Conclusion
This is a pilot study showing that it is feasible and appropriate to use the postoperative quality of recovery scale (PQRS) in postoperative recovery assessment. Preliminary assessment of this result shows that anesthesia strategy with deep rocuronium-induced neuromuscular blockade-sugammadex reversal improved postoperative recovery versus the routine care with moderate neuromuscular block-neostigmine.

Highlights
Calibrated river-level estimation from river cameras using convolutional neural networks
Authors: Vandaele Remy , Dance Sarah L. , Ojha Varun 
Published: May 2023

Abstract
Monitoring river water levels is essential for the study of floods and mitigating their risks. River gauges are a well-established method for river water-level monitoring but many flood-prone areas are ungauged and must be studied through gauges located several kilometers away. Taking advantage of river cameras to observe river water levels is an accessible and flexible solution but it requires automation. However, current automated methods are only able to extract uncalibrated river water-level indexes from the images, meaning that these indexes are relative to the field of view of the camera, which limits their application. With this work, we propose a new approach to automatically estimate calibrated river water-level indexes from images of rivers. This approach is based on the creation of a new dataset of 32,715 images coming from 95 river cameras in the UK and Ireland, cross-referenced with gauge data (river water-level information), which allowed us to train convolutional neural networks. These networks are able to accurately produce two types of calibrated river water-level indexes from images: one for continuous river water-level monitoring, and the other for flood event detection. This work is an important step toward the automated use of cameras for flood monitoring.
Decomposition of multicorrelation sequences and joint ergodicity
Authors: DONOSO SEBASTIÁN , FERRÉ MORAGUES ANDREU , KOUTSOGIANNIS ANDREAS , SUN WENBO 
Published: May 2023

AbstractWe show that, under finitely many ergodicity assumptions, any multicorrelation sequence defined by invertible measure-preserving
$\mathbb {Z}^d$
-actions with multivariable integer polynomial iterates is the sum of a nilsequence and a nullsequence, extending a recent result of the second author. To this end, we develop a new seminorm bound estimate for multiple averages by improving the results in a previous work of the first, third, and fourth authors. We also use this approach to obtain new criteria for joint ergodicity of multiple averages with multivariable polynomial iterates on
${\mathbb Z}^{d}$
-systems.
Molecular characterization of a suspected IMP-type carbapenemase-producing Pseudomonas aeruginosa outbreak reveals two simultaneous outbreaks in a tertiary-care hospital
Authors: Gual-de-Torrella Ana , López-Causape Carla , Alejo-Cancho Izaskun , Rojo-Molinero Estrella , Sanchez-García Gonzalo , Cortés-Lara Sara , Rodríguez Moral María B. , Berdonces-Gonzalez Pilar , Lopez de Goikoetxea María J. , Oliver Antonio 
Published: May 2023

AbstractObjective:To describe IMP-type carbapenemase-producing Pseudomonas aeruginosa outbreaks at Galdakao University Hospital between March 2021 to December 2021.Design:Outbreak report.Setting:Galdakao University Hospital is a tertiary-care hospital in the Basque Country (northern Spain).Patients:All patients with a positive IMP-type carbapenemase producing Pseudomonas aeruginosa (IMP-PA) culture were included in this study, both colonization and infection cases.Methods:An outbreak investigation was conducted, in which molecular epidemiology analysis [pulsed-field gel electrophoresis and whole-genome sequencing (WGS)] and environmental screenings were performed.Results:Between March and December 2021, 21 cases of IMP-PA were detected in Galdakao University Hospital: 18 infection cases and 3 colonization cases. In total, 4 different pulsotypes were detected belonging to 4 clones according to WGS: ST175 (n = 14), ST633 (n = 3), ST179 (n = 3), and ST348 (n = 1). IMP-13 was detected in most isolates belonging to the ST175 clone and in all ST179 and ST348 clones, whereas IMP-29 was detected in isolates belonging to the ST633 clone. Clinical isolates belonging to the ST175 clone were isolated mainly from patients admitted to the respiratory ward, and isolates belonging to the ST633 clone from patients admitted to the ICU. Two environmental isolates belonging to the ST175 clone were detected in the respiratory ward.Conclusions:Molecular and genomic epidemiology revealed that there had been 2 independent IMP-PA outbreaks, one of long duration in the respiratory ward and the other more limited in the ICU.
Frequency effects in Spanish phonological speech errors: Weak sources in the context of weak syllables and words
Authors: Santiago Julio , Pérez Elvira , Palma Alfonso , Stemberger Joseph Paul 
Published: May 2023

AbstractThe present study examines the effects of the frequency of phoneme, syllable, and word units in the Granada corpus of Spanish phonological speech errors. We computed several measures of phoneme and syllable frequency and selected the most sensitive ones, along with word (lexeme) frequency to compare the frequencies of source, target, and error units at the phoneme, syllable, and word levels. Results showed that phoneme targets have equivalent frequency to matched controls, whereas source phonemes are lower in frequency than chance (the Weak Source effect) and target phonemes (the Davideffect). Target, source, and error syllables and words also were of lower frequency than chance, and error words (when they occur) were lowest in frequency. Contrary to most current theories, which focus on faulty processing of the target units, present results suggest that faulty processing of the source units (phonemes, syllables, and words) is an important factor contributing to phonological speech errors. Low-frequency words and syllables have more difficulty ensuring that their phonemes, especially those of low frequency, are output only in their correct locations.
Direct and indirect vaccination effects on SARS-CoV-2 infection in day-care centres: Evaluating the policy for early vaccination of day-care staff in Germany, 2021
Authors: Schoeps Anja , Walter Jan , Vogt Manfred , Bent Stefan , Zanger Philipp ,   the Palatina Public Health Study Group
Published: May 2023

Abstract
To mitigate the known high transmission risk in day-care facilities for children aged 0–6 years, day-care staff were given priority for SARS-CoV-2 vaccination in Rhineland-Palatinate, Germany, in March 2021. This study assessed direct and indirect effects of early vaccination of day-care staff on SARS-CoV-2 transmission in daycares with the aim to provide a basis for the prioritisation of scarce vaccines in the future. Data came from statutory infectious disease notifications in educational institutions and from in-depth investigations by the district public health authorities. Using interrupted time series analyses, we measured the effect of mRNA-based vaccination of day-care staff on SARS-CoV-2 infections and transmission. Among 566 index cases from day-care centres, the mean number of secondary SARS-CoV-2 infections per index case dropped by −0.60 case per month after March 2021. The proportion of staff among all cases reported from daycares was around 60% in the pre-interruption phase and significantly decreased by 27 percentage points immediately in March 2021 and by further 6 percentage points each month in the post-interruption phase. Early vaccination of day-care staff reduced SARS-CoV-2 cases in the overall day-care setting and thus also protected unvaccinated children. This should inform future decisions on vaccination prioritisation.
Which Potential Evapotranspiration Formula to Use in Hydrological Modeling World‐Wide?
Authors: Pimentel R. , Arheimer B. , Crochemore L. , Andersson J. C. M. , Pechlivanidis I. G. , Gustafsson D. 
Published: May 2023

AbstractAlthough many potential evapotranspiration (PET) formulas are available, there is still a lack of knowledge on when and where to use them in catchment modeling world‐wide. Here we experimented with three different formulas in a global hydrological model (the World‐wide HYPE), using 15 years of observations from 5,338 streamflow gauges and global evapotranspiration from Earth‐observations (MOD16). We tested model performance in a multi‐process approach to select the best formula for catchments covering the global landmass. From comparing the results with land‐cover, climate classification, water‐energy limitations, we found that climate is the main driver behind the spatial patterns in model performance. Hargreaves was the best PET formula in 50% of the catchments, most of them located in the Amazonas, central Europe, and Oceania; Jensen‐Haise was better for catchments in northern latitudes (36%). Finally, Priestley‐Taylor was the best formula for India and latitudes above 65° North. The selection of a PET formula seems to be more critical in tropical regions close to the equator, where the differences in performance are above 50%. This is also where PET is highest. We found a strong connection between the five main Köppen regions and the PET formulas, further supported by landcover analysis. Hence, the PET formulas differed in their capacity to provide useful input to the water balance modeling, with complex formulas only giving improved predictions in temperate and polar regions; however, for the rest of the globe simpler formulas were better. We thus recommend to apply different PET formulas based on climatic regions world‐wide.
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer
Authors: Guenther Michael , Surendran Sai Agash , Haas Michael , Heinemann Volker , von Bergwelt-Baildon Michael , Engel Jutta , Werner Jens , Boeck Stefan , Ormanns Steffen 
Published: May 2023

Abstract
Background
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) overexpression in human tumours is associated with increased malignancy. Its effect on gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC) has not been studied yet.

Methods
The prognostic impact of TPX2 expression was examined in the tumour tissue of 139 patients with advanced PDAC (aPDAC) treated within the AIO-PK0104 trial or translational trials and of 400 resected PDAC (rPDAC) patients. The findings were validated using RNAseq data of 149 resected PDAC patients.

Results
In the aPDAC cohorts, 13.7% of all samples showed high TPX2 expression, conferring significantly shorter progression-free survival (PFS, HR 5.25, P < 0.001) and overall survival times (OS, HR 4.36, P < 0.001) restricted to gemcitabine-based treated patients (n = 99). In the rPDAC cohort, 14.5% of all samples showed high TPX2 expression, conferring significantly shorter disease-free survival times (DFS, HR 2.56, P < 0.001) and OS times (HR 1.56, P = 0.04) restricted to patients treated with adjuvant gemcitabine. RNAseq data from the validation cohort confirmed the findings.

Conclusions
High TPX2 expression may serve as a negative predictor of gemcitabine-based palliative and adjuvant chemotherapy in PDAC and could be used to inform clinical therapy decisions.

Clinical trial registry
The clinical trial registry identifier is NCT00440167.
Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET
Authors: Kanellis Dimitris C. , Zisi Asimina , Skrott Zdenek , Lemmens Bennie , Espinoza Jaime A. , Kosar Martin , Björkman Andrea , Li Xuexin , Arampatzis Stefanos , Bartkova Jirina , Andújar-Sánchez Miguel , Fernandez-Capetillo Oscar , Mistrik Martin , Lindström Mikael S. , Bartek Jiri 
Published: May 2023

AbstractDrug repurposing is a versatile strategy to improve current therapies. Disulfiram has long been used in the treatment of alcohol dependency and multiple clinical trials to evaluate its clinical value in oncology are ongoing. We have recently reported that the disulfiram metabolite diethyldithiocarbamate, when combined with copper (CuET), targets the NPL4 adapter of the p97VCP segregase to suppress the growth of a spectrum of cancer cell lines and xenograft models in vivo. CuET induces proteotoxic stress and genotoxic effects, however important issues concerning the full range of the CuET-evoked tumor cell phenotypes, their temporal order, and mechanistic basis have remained largely unexplored. Here, we have addressed these outstanding questions and show that in diverse human cancer cell models, CuET causes a very early translational arrest through the integrated stress response (ISR), later followed by features of nucleolar stress. Furthermore, we report that CuET entraps p53 in NPL4-rich aggregates leading to elevated p53 protein and its functional inhibition, consistent with the possibility of CuET-triggered cell death being p53-independent. Our transcriptomics profiling revealed activation of pro-survival adaptive pathways of ribosomal biogenesis (RiBi) and autophagy upon prolonged exposure to CuET, indicating potential feedback responses to CuET treatment. The latter concept was validated here by simultaneous pharmacological inhibition of RiBi and/or autophagy that further enhanced CuET’s tumor cytotoxicity, using both cell culture and zebrafish in vivo preclinical models. Overall, these findings expand the mechanistic repertoire of CuET’s anti-cancer activity, inform about the temporal order of responses and identify an unorthodox new mechanism of targeting p53. Our results are discussed in light of cancer-associated endogenous stresses as exploitable tumor vulnerabilities and may inspire future clinical applications of CuET in oncology, including combinatorial treatments and focus on potential advantages of using certain validated drug metabolites, rather than old, approved drugs with their, often complex, metabolic profiles.
Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia
Authors: Sugita Mayumi , Yamazaki Takahiro , Alhomoud Mohammad , Martinet Jérémie , Latouche Jean-Baptiste , Golden Encouse , Boyer Olivier , Van Besien Koen , Formenti Silvia C. , Galluzzi Lorenzo , Guzman Monica L. 
Published: May 2023

AbstractAutologous T cells engineered to express a chimeric antigen receptor (CAR) specific for CD19 are approved for the treatment of various CD19+ hematological malignancies. While CAR T cells induce objective responses in a majority of patients, relapse frequently occurs upon loss of CD19 expression by neoplastic cells. Radiation therapy (RT) has been successfully employed to circumvent the loss of CAR targets in preclinical models of pancreatic cancer. At least in part, this reflects the ability of RT to elicit death receptor (DR) expression by malignant cells, enabling at least some degree of CAR-independent tumor killing. In a human model of CD19+ acute lymphoblastic leukemia (ALL), we also observed DR upregulation by RT, both in vitro and in vivo. Moreover, low-dose total body irradiation (LD-TBI) delivered to ALL-bearing mice prior to CAR T cell infusion considerably extended the overall survival benefit afforded by CAR T cells alone. Such an improved therapeutic activity was accompanied by a superior expansion of CAR T cells in vivo. These data encourage the initiation of clinical trials combining LD-TBI with CAR T cells in patients with hematological malignancies.
Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition
Authors: Sheikh Arsheed H. , Zacharia Iosif , Pardal Alonso J. , Dominguez-Ferreras Ana , Sueldo Daniela J. , Kim Jung-Gun , Balmuth Alexi , Gutierrez Jose R. , Conlan Brendon F. , Ullah Najeeb , Nippe Olivia M. , Girija Anil M. , Wu Chih-Hang , Sessa Guido , Jones Alexandra M. E. , Grant Murray R. , Gifford Miriam L. , Mudgett Mary Beth , Rathjen John P. , Ntoukakis Vardis 
Published: May 2023

AbstractIn both plants and animals, nucleotide-binding leucine-rich repeat (NLR) immune receptors play critical roles in pathogen recognition and activation of innate immunity. In plants, NLRs recognise pathogen-derived effector proteins and initiate effector-triggered immunity (ETI). However, the molecular mechanisms that link NLR-mediated effector recognition and downstream signalling are not fully understood. By exploiting the well-characterised tomato Prf/Pto NLR resistance complex, we identified the 14-3-3 proteins TFT1 and TFT3 as interacting partners of both the NLR complex and the protein kinase MAPKKKα. Moreover, we identified the helper NRC proteins (NLR-required for cell death) as integral components of the Prf /Pto NLR recognition complex. Notably our studies revealed that TFTs and NRCs interact with distinct modules of the NLR complex and, following effector recognition, dissociate facilitating downstream signalling. Thus, our data provide a mechanistic link between activation of immune receptors and initiation of downstream signalling cascades.
Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling
Authors: Bian Fenghua , Lan Ying-Wei , Zhao Shuyang , Deng Zicheng , Shukla Samriddhi , Acharya Anusha , Donovan Johnny , Le Tien , Milewski David , Bacchetta Matthew , Hozain Ahmed Emad , Tipograf Yuliya , Chen Ya-Wen , Xu Yan , Shi Donglu , Kalinichenko Vladimir V. , Kalin Tanya V. 
Published: May 2023

AbstractPulmonary fibrosis results from dysregulated lung repair and involves multiple cell types. The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA-sequencing we identified endothelial transcription factors involved in lung fibrogenesis, including FOXF1, SMAD6, ETV6 and LEF1. Focusing on FOXF1, we found that FOXF1 is decreased in EC within human idiopathic pulmonary fibrosis (IPF) and mouse bleomycin-injured lungs. Endothelial-specific Foxf1 inhibition in mice increased collagen depositions, promoted lung inflammation, and impaired R-Ras signaling. In vitro, FOXF1-deficient EC increased proliferation, invasion and activation of human lung fibroblasts, and stimulated macrophage migration by secreting IL-6, TNFα, CCL2 and CXCL1. FOXF1 inhibited TNFα and CCL2 through direct transcriptional activation of Rras gene promoter. Transgenic overexpression or endothelial-specific nanoparticle delivery of Foxf1 cDNA decreased pulmonary fibrosis in bleomycin-injured mice. Nanoparticle delivery of FOXF1 cDNA can be considered for future therapies in IPF.
Confining donor conformation distributions for efficient thermally activated delayed fluorescence with fast spin-flipping
Authors: Qiu Weidong , Liu Denghui , Li Mengke , Cai Xinyi , Chen Zijian , He Yanmei , Liang Baoyan , Peng Xiaomei , Qiao Zhenyang , Chen Jiting , Li Wei , Pu Junrong , Xie Wentao , Wang Zhiheng , Li Deli , Gan Yiyang , Jiao Yihang , Gu Qing , Su Shi-Jian 
Published: May 2023

AbstractFast spin-flipping is the key to exploit the triplet excitons in thermally activated delayed fluorescence based organic light-emitting diodes toward high efficiency, low efficiency roll-off and long operating lifetime. In common donor-acceptor type thermally activated delayed fluorescence molecules, the distribution of dihedral angles in the film state would have significant influence on the photo-physical properties, which are usually neglected by researches. Herein, we find that the excited state lifetimes of thermally activated delayed fluorescence emitters are subjected to conformation distributions in the host-guest system. Acridine-type flexible donors have a broad conformation distribution or bimodal distribution, in which some conformers feature large singlet-triplet energy gap, leading to long excited state lifetime. Utilization of rigid donors with steric hindrance can restrict the conformation distributions in the film to achieve degenerate singlet and triplet states, which is beneficial to efficient reverse intersystem crossing. Based on this principle, three prototype thermally activated delayed fluorescence emitters with confined conformation distributions are developed, achieving high reverse intersystem crossing rate constants greater than 106s−1, which enable highly efficient solution-processed organic light-emitting diodes with suppressed efficiency roll-off.