bluuebunny/crossref_metadata_2025_split huggingface dataset:
The State of Genetics and Genomics Education in US Physician Assistant Programs
Authors: Patterson Wesley G. , Tribble Leta M. , Hopkins Casey S. , Fasolino Tracy K. , Ward Linda D. 
Published: July 2023

Purpose
This study aimed to assess the current landscape of genetics-genomics education in physician assistant (PA) student training.

Methods
A 25-question electronic survey was emailed to program directors of the 273 accredited PA programs. Questions represented PA program demographics and 4 domains: curricular characteristics and perceived adequacy; content; curricular approaches and instructional methods; and intent, barriers, and perceived needs for an optimal curriculum.

Results
A total of 115 PA program representatives (42%) returned the survey. More than two-thirds of responding programs do not require a prerequisite genetics course for matriculation. Most programs (48%) include 1 to 10 contact hours of genetics-genomics content and use various content delivery methods and approaches. Most programs (67%) use PA program faculty to teach genetics-genomics as part of one course or many courses throughout the curriculum (85%) using didactic lectures (97%). The most significant barrier to developing an optimal curriculum is an already overloaded curriculum (71%). Physician assistant educators welcome supportive resources, such as genetic case studies (96%).

Conclusions
The study findings elucidate the current state of genetics-genomics education in PA programs. Every responding program reports that genetics-genomics is integrated into their curriculum; however, no standardization exists between programs. Although medical genetics-genomics has changed and advanced rapidly since a similar survey was conducted 14 years ago, the number of contact hours is unchanged, and genetics-genomics content is less dispersed throughout PA curricula. To create genetic-competent and genomic-competent PAs, education must evolve to stay current with ongoing advancements in genomic science.
Contribution of carbon inputs to soil carbon accumulation cannot be neglected
Authors: He Xianjin , Abramoff Rose , Abs Elsa , Georgiou Katerina , Zhang Haicheng , Goll Daniel S. 
Published: July 2023

AbstractIn a recently published paper (1), the authors report that microbial carbon use efficiency (CUE) is the primary determinant of global soil organic carbon (SOC) storage and that the relative impact of plant carbon inputs on SOC is minor. While soil microbes undoubtedly play an important role in soil organic carbon cycling, we are concerned about the robustness of the approach taken by Tao et al. (1) and highlight potential biases in their analyses that may lead to misleading, model-dependent results.
Barriers and facilitators of physical activity in adults with severe haemophilia: A qualitative study
Authors: Cotino Claudia , Pérez‐Alenda Sofía , Cruz‐Montecinos Carlos , López‐Bueno Rubén , Núñez‐Cortés Rodrigo , Suso‐Martí Luís , Mendez‐Rebolledo Guillermo , Andersen Lars Louis , Casaña José , Calatayud Joaquín 
Published: July 2023

AbstractBackgroundPeople with haemophilia (PWH) tend to be less physically active than the general population, but there is a lack of research on the specific barriers and facilitators affecting their participation in physical activities.ObjectivesThis study aims to explore perceived barriers and facilitators to physical activity in severe PWH.DesignAn explorative qualitative study based on focus groups.MethodsFour focus groups including 16 participants (severe haemophilia A patients) were conducted to examine the factors perceived as facilitators or barriers to haemophiliacs engaging in physical activity. One researcher conducted a thematic analysis of all data.ResultsThree themes were identified: body function, personal factors, and environmental factors. Key facilitators identified were access to prophylaxis treatment to reduce the risk of bleeding(s), the enjoyability of physical activity, fitness and health motives, social interaction, support, and low cost. PWH faced additional barriers to being physically active including hurtful joints, mobility issues, haemophilic arthropathy, dislike or disinterest, lack of motivation, fear of injury, tiredness, lack of time, lack of guidance, negative social influence, restriction, and lack of coordination of prophylaxis treatment.ConclusionThis exploratory study demonstrated that participation in physical activity in PWH is influenced not only by their own abilities and attitudes, but also by external variables, including family, friends, healthcare professionals, structures, and communities. The results of this study may be used to assist caregivers and health professionals, inform programs, interventions, and policies to promote physical activity and health in severe PWH.
Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
Authors: Zhang Jingjie , Meng Xianmei , Zhou Yi , Jiang Zhengyu , Chen Hongsuo , Meng Zhiyi , Zhang Qi , Chen Weichang 
Published: July 2023

AbstractNumerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but the role of lnc-LRRTM4 in the progression of CRC remains unclear. In this article, we found that lnc-LRRTM4 was highly expressed in CRC tissues and cell lines and that lnc-LRRTM4 could promote the proliferation and metastasis of CRC cells. These consequences were achieved by lnc-LRRTM4 directly binding to the promoter of LRRTM4 to induce its transcription. Moreover, lnc-LRRTM4 enhanced the growth of CRC cells in vivo by promoting cell cycle progression and reducing apoptosis. Taken together, our results revealed that lnc-LRRTM4 promotes the proliferation and metastasis of CRC cells, suggesting that it may be a potential diagnostic and therapeutic target for CRC.
The crystal structure of 1-propyl-2-nitro-imidazole oxide, C6H9N3O3
Authors: Jun Yuan , Bingheng Wu , Yong Wang , Jianlong Wang , Duanlin Cao , Lizhen Chen 
Published: July 2023

Abstract
C6H9N3O3, monoclinic, P21/n (no. 14), a = 9.5584(4) Å, b = 6.7828(3) Å, c = 12.8337(6) Å, β = 103.8810(10)∘, V = 807.74(6) Å3, Z = 4, R

gt
(F) = 0.0455, wR

ref
(F
2) = 0.1166, T = 170.0 K.
La tradición del doble en El otoño del patriarca
Authors: Motato C Hernando 
Published: July 2023

El enfoque analítico de esta novela garciamarquiana está centrado en la forma en la que su autor recoge obras clave de la literatura y del pensamiento universales, tales como el poema del Gilgamesh, La comedia de las equivocaciones, de Shakespeare, y el texto Esaú y Jacob, de la Biblia, entre otros, a fin de darle un sentido paródico con las figuras del doble de dichas obras. asimismo, retomo la presencia del doble en sus primeros cuentos: «La otra costilla de la muerte» y «Diálogo del espejo». A su vez, como también ese otro yo entre el médico y el cura en La hojarasca; igualmente, en la simetría de los espejos entre los hermanos gemelos de Cien años de soledad, hasta llegar al doble propiamente dicho en El otoño del patriarca, visto a través de la dualidad del poder entre Patricio Aragonés y el patriarca que es el punto culminante con el cual García Márquez cierra el horizonte estético en torno a la configuración del doble.
La geometría del agua: una luz pregunta por nosotros
Authors: Meza Barrios Jessica 
Published: July 2023

En este artículo[1] presentamos una aproximación al poemario de Fernando Denis (1968), La geometría del agua (2009), basándonos en los presupuestos de la fenomenología de Gaston Bachelard. En este texto analizaremos el lugar que ocupa dicha ensoñación en su visión alegórica del mundo y como las isotopías simbólicas como el mar de las imágenes, el jardín, los bosques, los colores, los pájaros místicos, la luz del fuego, los árboles, el cielo y la memoria permitirán transformar la existencia en un sueño. Y esa visión romántica apuntará a la recuperación de la identidad del ser, asumiendo una lectura mítica de la vida y la realidad.
Arrayán: la flor de nuestra memoria
Authors: Márquez Cristo Gonzalo 
Published: July 2023

Al leer Arrayán de Julio César Goyes que reúne sus libros El eco y la mirada (2001) y El quinde y los geranios (2013), nos queda la certidumbre de que la niñez es el único territorio donde todavía vuela el colibrí. En el primero de sus poemarios el tránsito se inicia en un patio de arrayanes con cuyes, donde una infancia expectante festeja la tierra natal del autor (Ipiales), para luego emprender el descubrimiento de una interiorizada Europa poblada de signos y evocaciones, mientras la indagadora escritura no renuncia a ser deseo y origen, y arrastra en el torrente el linaje de sus palabras de sol y sus silencios de luna.
¿Cuentos para fomentar el turismo o la ideología de la Generación del Treinta?
Authors: Báez Arroyo María I. 
Published: July 2023

En este ensayo se destaca al escritor Emilio S. Belaval, de la llamada Generación del Treinta en Puerto Rico, que ha sido reconocido como uno de nuestros mejores cuentistas. Esta generación del siglo 20 ha sido muy comentada por sus posiciones ideológicas, las cuales mantuvieron y sostuvieron en muchos ensayos y además, en la narrativa de ese momento. El objetivo principal de este escrito es destacar qué la caracterización tanto de las feminidades como las masculinidades en el libro Cuentos para fomentar el turismo (1977) de Emilio S. Belaval responden a las concepciones ideológicas de la Generación del Treinta en Puerto Rico.
Jorge Teillier. El poeta de este mundo
Authors: Ordóñez Jorge Eliecer 
Published: July 2023

Se trata de un rastreo a la poética de Jorge Teillier, autor chileno que trabaja con vehemencia la llamada Poesía Lárica (de los lares), es decir, la que evidencia la experiencia de la casa y su entorno: la aldea, el territorio primigenio, donde el trabajo, los afectos iniciáticos, el paisaje, la saga familiar, los pioneros, están a la orden del día. Es una poesía que viaja en tren cuando el avión ya ha sobrepasado a la mula.
La física poscuántica: sexualidades alternativas en la ciencia ficción y novum de Vagabunda Bogotá de Luis Carlos Barragán
Authors: Avendaño Cumplido Eduardo 
Published: July 2023

Teniendo como eje el concepto de novum de Darko Suvin, y estableciendo una estrecha relación con la teoría queer, este artículo analiza la novela Vagabunda Bogotá de Luis Carlos Barragán como una propuesta ficcional que permite abordar una visión no binaria del género, al tiempo que expande imaginariamente el campo de la sexualidad. Para ello, el artículo ofrece un previo mapeo sobre el estatuto del género de ciencia ficción en Latinoamérica y en el marco de la literatura colombiana donde se inscribe la novela de Barragán.
PERANCANGAN TONGKAT BANTU INOVATIF UNTUK TUNANETRA DENGAN MEMANFAATKAN TEKNOLOGI SENSOR GYROSCOPE, GPS DAN ULTRASONIK
Authors: Pambudi Agung , Leonardo Muhammad Diego 
Published: July 2023

<p>The eyes are vital human sensory organs that react to light. One of the functions of the eyes is to record the state or surrounding conditions, to know the object. Then, <a href="https://id.wikipedia.org/wiki/Sel_kerucut">cones </a>on the <a href="https://id.wikipedia.org/wiki/Retina">retina </a>allow<strong> </strong>conscious light perception and vision, such as color differentiation and depth perception. The purpose of the research was to develop stick-based technology gyroscope sensors, GPS, and ultrasonic-based microcontrollers. The development of this tool aimed at helping blind people to detect objects around them so that blind people could walk well. The approach in this development utilized the Research an<strong>d </strong>Development (R&amp;D) method, and the testing used the Alpha method. The test results showed that all tools could function properly and could be implemented in the field.</p><p> </p>
Mathematical Models of the UAV Operators
Authors: Szabolcsi Róbert 
Published: July 2023

Abstract
The operators maintaining different kinds of activities might have different mathematical models regarding their physical and mental status, their skills and experiences, their level of training they own. Recent days more and more attention is paid to wide spread of different UAVs applied both in military and in non-military governmental applications. The UAV production industry is able to manufacture UAVs for different and diverging purposes. However, the effective maintenance of these UAVs requires highly trained and qualified operators. When massive UAV applications support combating ground forces in the war theatre the training of the UAV operators becomes to be one of the crucial criteria. Diversity of the UAV types often fabricated and gunned for military purposes shows difficulties of the training program created for UAV operators. This paper addresses mathematical models of the UAV operators applied both in open and closed loop control systems of the UAVs. Additionally, findings of this paper might support and improve selection process of the UAV operators to reach maximum efficiency of both military reconnaissance and combat applications.
Ivan Gavrilovich Alexandrov. Pages of Life and Achievements
Authors: Grigoriev N. D. 
Published: July 2023

Academician Ivan Gavrilovich Alexandrov is an outstanding hydropower engineer, the founder of the integrated design of large hydroelectric plants and irrigation systems, the developer of the GOELRO plan, the author of original innovative ideas, which then seriously influenced further development of hydropower engineering and are still of practical importance, the creator of DneproGES. The Angarsk HPP cascade was also designed according to the developments and proposals of Ivan G. Alexandrov. A brilliant researcher, designer, economist, teacher, manager, and administrator graduated from Moscow Engineering School (now Russian University of Transport).Ivan Alexandrov was recognised worldwide as an outstanding scientist and engineer. His activities mainly fell on the most difficult years of formation of the national economy of the USSR, on the years of the first five-year plans…For many years he taught at the higher educational institutions of Leningrad and Moscow and enjoyed great love and respect among students.
Analysis of the Relationship between Rail Cant and Track Gauge Based on the Data Obtained by Track Recording Cars
Authors: Gallyamov D. I. , Ovchinnikov D. V. 
Published: July 2023

The increase in the service life of track superstructure has always been an important task since this allows reduction in the cost of repairs and current maintenance of the track.The objective of the work is to determine the mutual influence of the rail cant and the track gauge based on the results of measurements carried out by track recording cars, as well as their impact on the stress-strain state of the rail. The analysis was based on statistical and the finite element methods. Using statistical methods, it was determined that the rail cant and track gauge values do not have a normal distribution and have a weak feedback. The reasons were explained in the conclusions.To determine with the finite element method contact stresses in the rail head on the track sections available in the sample, with different combinations of rail cant and track gauge, a model with full geometric similarity was developed.The results obtained from the calculations demonstrate that the deviation of the cant within the range from 1/15 to 1/30 leads to an increase in stresses by more than 20 %, while changing the track gauge has a weak effect on the stress-strain state of the rail head. The maximum increase in contact stresses, at the analysed section, was 97 %, with a cant of 1/990 and a track gauge of 1526 mm.The growth of contact stresses leads to the formation of fatigue cracks and, as a consequence, to the defects and then to replacement of the rail. To increase the service life of the rails, it is recommended to monitor the condition of fasteners and compliance with the technology of current maintenance works, as well as to reconsider tolerance of the deviation of the cant both upward and downward.
DNA methylation profiling in Trisomy 21 females with and without breast cancer
Authors: Bejaoui Yosra , Alresheq Sara , Durand Sophie , Vilaire-Meunier Marie , Maillebouis Louise , Zen Ayman Al Haj , Mégarbané André , Hajj Nady El 
Published: July 2023

BackgroundDown Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer however they are at higher risk of developing acute myeloid leukemia and acute lymphoblastic leukemia.MethodsIn this study, we investigated DNA methylation signatures and epigenetic aging in DS individuals with and without breast cancer. We analyzed DNA methylation patterns in Trisomy 21 (T21) individuals without breast cancer (T21-BCF) and DS individuals with breast cancer (T21-BC), using the Infinium Methylation EPIC BeadChip array.ResultsOur results revealed several differentially methylated sites and regions in the T21-BC patients that were associated with changes in gene expression. The differentially methylated CpG sites were enriched for processes related to serine-type peptidase activity, epithelial cell development, GTPase activity, bicellular tight junction, Ras protein signal transduction, etc. On the other hand, the epigenetic age acceleration analysis showed no difference between T21-BC and T21-BCF patients.ConclusionsThis is the first study to investigate DNA methylation changes in Down syndrome women with and without breast cancer and it could help shed light on factors that protect against breast cancer in DS.
The role of green finance in reducing agricultural non-point source pollution—an empirical analysis from China
Authors: Lv Wen , Zhang Zheng , Zhang Xiaran 
Published: July 2023

IntroductionGreen finance plays a crucial role in driving sustainable development and has the potential to effectively reduce pollution emissions, thereby positively impacting the environment. However, in the agricultural sector, China, unlike developed countries, primarily relies on a small-peasant economy, and the green financial system is not well-developed. As a result, the specific emission reduction effects and mechanisms of green finance on agricultural non-point source pollution (ANSP) remain unclear. The objective of our research is to explore the internal mechanisms through which green finance influences ANSP, with the aim of providing valuable policy insights to the government and promoting the green transformation of agriculture for enhanced food security.MethodsThis study employs an empirical analysis of green finance on ANSP using provincial panel data from China spanning the years 2005 to 2020. By utilizing robust data and applying empirical analysis, we can derive scientifically credible conclusions. We introduce a relative indicator to assess the trend of ANSP and investigate the pathways through which green finance operates using heterogeneity analysis, intermediary effect evaluation, and threshold effect analysis.Results and DiscussionThe empirical findings reveal the following insights: (1) While green finance demonstrates a significant reduction effect on ANSP, this effect varies across different regions. Specifically, the impact of green finance on ANSP reduction is more pronounced in areas characterized by strong comprehensive agricultural strength, high levels of economic development, and predominantly focused on plantation agriculture. (2) From a mechanistic standpoint, green finance substantially diminishes ANSP by facilitating agricultural scaling and promoting the adoption of green technologies. (3) The threshold effect analysis demonstrates that the mitigation effect of green finance on ANSP exhibits non-linear characteristics, with a double threshold effect observed. As the level of green finance development increases, the mitigation effect is further enhanced.ConclusionIn conclusion, the appropriate implementation of green finance can effectively enhance the agricultural environment and ensure food security. Considering the heterogeneity of the role of green finance and the presence of threshold values, it is crucial for the government to tailor green finance policies according to local conditions. This research not only expands on previous studies but also offers valuable insights for the government in formulating green finance policies. Furthermore, it provides a viable pathway for reducing ANSP while serving as a reference for other developing countries aiming to establish green agriculture and sustain food system security.
The JWST PEARLS View of the El Gordo Galaxy Cluster and of the Structure It Magnifies
Authors: Frye Brenda L. , Pascale Massimo , Foo Nicholas , Leimbach Reagen , Garuda Nikhil , Robles Paulina Soto , Summers Jake , Diaz Carlos , Kamieneski Patrick , Furtak Lukas J. , Cohen Seth H. , Diego Jose , Beauchesne Benjamin , Windhorst Rogier A. , Willner S. P. , Koekemoer Anton M. , Zitrin Adi , Caminha Gabriel , Caputi Karina I. , Coe Dan , Conselice Christopher J. , Dai Liang , Dole Hervé , Driver Simon P. , Grogin Norman A. , Harrington Kevin , Jansen Rolf A. , Kneib Jean-Paul , Lehnert Matt , Lowenthal James , Marshall Madeline A. , Menanteau Felipe , Pampliega Belén Alcalde , Pirzkal Nor , Polletta Mari , Richard Johan , Robotham Aaron , Ryan Russell E. , Rutkowski Michael J. , Sifón Christóbal , Tompkins Scott , Wang Daniel , Yan Haojing , Yun Min S. 
Published: July 2023

Abstract
The massive galaxy cluster El Gordo (z = 0.87) imprints multitudes of gravitationally lensed arcs onto James Webb Space Telescope Near-Infrared Camera (NIRCam) images. Eight bands of NIRCam imaging were obtained in the “Prime Extragalactic Areas for Reionization and Lensing Science” (“PEARLS”) program. Point-spread function–matched photometry across Hubble Space Telescope and NIRCam filters supplies new photometric redshifts. A new light-traces-mass lens model based on 56 image multiplicities identifies the two mass peaks and yields a mass estimate within 500 kpc of (7.0 ± 0.30) × 1014
M
⊙. A search for substructure in the 140 cluster members with spectroscopic redshifts confirms the two main mass components. The southeastern mass peak that contains the brightest cluster galaxy is more tightly bound than the northwestern one. The virial mass within 1.7 Mpc is (5.1 ± 0.60)×1014
M
⊙, lower than the lensing mass. A significant transverse velocity component could mean the virial mass is underestimated. We contribute one new member to the previously known z = 4.32 galaxy group. Intrinsic (delensed) positions of the five secure group members span a physical extent of ∼60 kpc. 13 additional candidates selected by spectroscopic/photometric constraints are small and faint, with a mean intrinsic luminosity ∼2.2 mag fainter than L
*. NIRCam imaging admits a fairly wide range of brightnesses and morphologies for the group members, suggesting a more diverse galaxy population in this galaxy overdensity.
O TRATADO DA CIRCUNFERÊNCIA DE AL-KĀSHĪ
Authors: Morey Bernadete , França Kaline Andreza 
Published: July 2023

O artigo apresenta uma tradução para o português do Tratado da Circunferência escrito pelo estudioso islâmico Jamshīd al- Kāshī em 1427. A tradução para o português teve como base o texto russo publicado no volume 7 da revista IstorikoMatematitcheskie Issledovaniya de 1954, traduzido por Boris Rozenfeld a partir do manuscrito árabe de Istambul. O presente artigo está organizado em duas grandes partes, sendo a primeira parte dedicada à apresentação do Tratado em seus diversos aspectos e a segunda parte consiste no texto em português do Tratado traduzidos do russo por Bernadete Morey