bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of astragaloside IV in extracellular matrix remodeling in fibrotic heart disease: Regulation of TRPM7-dependent macrophage function
Authors: Zhao Yi-Zhuo , Xu Ying , Feng Kai , Fan Xue-Ting , Ma Yun-Tian , Yan Hui-Ying , Liu Qian-Ru , Tang Yi-Qun 
Published: April 2023

Abstract
Background: Astragaloside IV (ASG), the main active constituent of Astragalus membranaceus, exerts protective effects against several diseases associated with myocardial fibrosis, while no data suggest its role on macrophages in the process of myocardial fibrosis. This study aimed to investigate the regulatory effects of ASG on macrophages during extracellular matrix remodeling in fibrotic heart disease
Methods and Results: Cardiac fibrosis of Sprague Dawley rats was induced by isoproterenol (5 mg/kg/day, s.c.) for 14 days, and ASG (10 mg/kg/day, 50 mg/kg/day, p.o.) treatment was administered from the 6th day of modeling. Histopathological changes and cytokines secretion by macrophages were observed. NIH-3T3 cells were incubated with the conditioned supernatant of the hypoxia model RAW 264.7 cells to investigate the involvement of macrophage-secreted cytokines. The results showed that cardiac fibrosis accompanied by infiltration of macrophages attenuated after ASG treatment. Importantly, ASG counteracted the activation of the miR-135a-TRPM7-TGF-β1/Smad3 pathway in primary macrophages and the increased levels of profibrotic cytokines in supernatants. In vitro, the conditioned medium secreted by RAW 264.7 macrophages stimulated the proliferation and differentiation of fibroblasts in a TRPM7-dependent manner. Moreover, patch-clamp data showed that ASG inhibited macrophage TRPM7 current in dose-dependent.
Conclusions: Our results suggest that macrophages promote the proliferation and differentiation of cardiac fibroblasts and remodeling of the extracellular matrix through paracrine function. In addition, TRPM7 may play an important role in the regulation of paracrine cytokines in macrophages. ASG remodeling the extracellular matrix and attenuating cardiac fibrosis by regulating macrophage activation via the miR-135a-TRPM7-TGF-β/Smads pathway.
Smith chart-based PSO algorithm for multi-objective engineering problems
Authors: Falloun Abdelbari , Dursun Yunus , Ozkaya Ufuk , Madi Abdessalam Ait 
Published: April 2023

Abstract
In this study, a new approach based on the Smith chart is proposed for multi-objective particle swarm optimization. With this approach, the position of each particle is updated according to the Smith chart’s impedance and admittance circles to determine the local best particle. The proposed method is applied to three test functions with different behaviors, namely concave, convex, and non-convex, and performance parameters are examined. In light of the obtained results, it has been observed that the proposed strategy offers successful convergence performance for multi-objective optimization applications and meets performance expectations with its obtained well-distributed solution set.
Dynamic prediction model of meteorological risk of offshore wind power
Authors: Tang Jiansong , Yang Ruijia , Dai Qiangsheng , Yuan Gaoteng , Mao Yingchi 
Published: April 2023

Abstract
In recent years, offshore wind farms, a crucial component of renewable energy, have attracted widespread interest and development worldwide. Nevertheless, offshore wind farms face a variety of meteorological risks during operation, including wind speed fluctuations, strong winds/storms, and extreme storms, which can have a significant impact on the safe operation and stable power generation of wind turbines. Existing methods for predicting meteorological risk frequently lack dynamism and adaptability, failing to meet the requirements of practical applications. This paper proposes a dynamic meteorological risk prediction method for offshore wind power based on hidden Markov models to address this issue. First, we propose four risk states based on the operation of offshore wind turbines under different wind speeds and meteorological conditions: extreme storm events, extreme ocean events, wind speed fluctuations, temperature fluctuations. Then, we construct state transition matrices and output matrices by collecting actual observational data (such as wind speed and wind direction) and combining expert experience and historical events. Finally, we use hidden Markov models to predict the risk states of offshore wind turbines in a dynamic manner. This paper uses artificially generated data to test and compare the performance of the proposed method, demonstrating that it significantly outperforms traditional Markov models and naive Bayes models in state prediction accuracy and is adaptable to some degree. In practical applications, the method can be continuously adjusted and optimized to improve prediction accuracy. By applying the dynamic meteorological risk prediction method for offshore wind power to actual scenarios, wind farm operators can receive real-time information about risks and take the necessary precautions to ensure the safe operation and stable power generation of wind turbines.
The more, the better? Social capital profiles and adolescent internalizing symptoms: A latent profile analysis
Authors: Pan Ye , Zhang Yifan , Ma Zijuan , Wang Dongfang , Ross Brendan , Huang Shuiqing , Fan Fang 
Published: April 2023

Abstract
Past research suggests that offline and online social capital are empirically linked to adolescent psychological adjustment. However, little is known regarding the implications of distinctive combinations of social capital for adolescent internalizing symptoms. The present study aimed to examine adolescent social capital patterns and their associations with internalizing symptoms by using Latent profile analysis. A cross-sectional web-based survey was conducted among 1595 Chinese adolescents (mean age = 14.30 years, 50.7% male). All adolescents completed self-report questionnaires on their perceived offline and online social capital, depressive symptoms and anxiety symptoms. Latent profile analysis revealed four profiles of social capital: 1) Low Social Capital, 2) Moderate Social Capital, 3) High Social Capital, and 4) Only High Offline Social Capital. Further, analysis of covariance demonstrated that the Only High Offline Social Capital profile had significantly fewer internalizing symptoms than other three profiles. No statistical differences of internalizing symptoms were found between the other three profiles, except for the difference in anxiety symptoms between the Moderate Social Capital profile and the Low Social Capital profile. These findings suggest that the more social capital does not equal to the better mental health status. The social capital profiles and their associations with adolescent internalizing symptoms may provide practitioners with meaningful implications regarding the role of offline and online social capital in adolescent psychological adjustment.
Comparison of three typical lithium-ion batteries for pure electric vehicles from the perspective of life cycle assessment
Authors: Jiang Tingting , Wang Huifang , Jin Qiang 
Published: April 2023

Abstract
In the present study, environmental impacts of lithium-ion batteries (LIBs) has become a concern due the large-scale production and application. The present paper aims to quantify the potential environmental impacts of three LIBs in terms of life cycle assessment (LCA), as well as to identify hotpots and ways to reduce the environmental impacts. Three different batteries are compared in this study: lithium iron phosphate (LFP) batteries, lithium nickel cobalt manganese oxide (NCM) 811 batteries and NCM622 batteries. The results show that the environmental impacts caused by LIBs is mainly reflected in five aspects from eleven evaluation indexes. They are abiotic depletion (fossil fuels), global warming (GWP 100a), human toxicity, fresh water aquatic ecotox and marine aquatic ecotoxicity. Besides, the "Production phase" and "Assembly phase" of LIBs are the main sources of carbon emissions, the GHG emission of NCM622 battery is 1576 kg CO2-eq/kWh, which accounts for 37.5% of the total GHG emissions. The study shows that the hydrometallurgical method in the "Recycle phase" may not always be environmentally friendly, it can increase the indicators of human toxicity, fresh water aquatic ecotox and marine aquatic ecotoxicity. The precursor materials in NCM batteries and the electricity consumption of LFP batteries are sensitive factors to environmental impacts, which can be effectively improved by improving the process and optimizing the power structure. The findings are likely to provide the LIBs manufacturing sector with data. Suggestions for process optimization of China's LIBs industry were proposed based on the adjustment projection of China's LIB industry.
Interference with CHD1L inhibits proliferation, promotes apoptosis and G2/M phase arrest and enhances cisplatin sensitivity of ovarian cancer cells through PLK1
Authors: Qiao Kun , Guan Yuanxiazi , Xing Wenjing 
Published: April 2023

Abstract
Background Chromodomain helicase/ATPase DNA-binding protein 1-like gene (CHDIL) is an oncogene with abnormal expression in ovarian cancer (OC), but its regulatory effects on proliferation, apoptosis, cycle arrest and cisplatin resistance of OC and its mechanisms have not been reported.Methods The expression of CHD1L in OC cell lines was detected by RT-qPCR and Western blot. After constructing CHD1L interference plasmids in CAOV-3 cells, cell proliferation and apoptosis were detected by CCK8, EDU staining, TUNEL and Western blot. Flow cytometry and Western blot were used to detect cell cycle. CCK8 and TUNEL were used to detect the role of CHD1L in the sensitivity of OC cells to cisplatin. Next, RT-qPCR, Western blot and IP were used to investigate the relationship between CHD1L and Polo-like Kinase 1 (PLK1). Finally, the regulation mechanism of CHD1L on OC development and cisplatin sensitivity was investigated by concurrently silencing the expression of CHD1L and overexpressing PLK1 in cells.Results The expression of CHD1L and PLK1 in OC cell lines was abnormally elevated. Interference with CHD1L in OC cells could significantly inhibit the proliferation, promote cell apoptosis and cycle arrest, and promote the sensitivity of OC cells to cisplatin. This process might be achieved through activation of PLK1.Conclusion Interference with CHD1L inhibited proliferation, promoted apoptosis and G2/M phase arrest and enhanced cisplatin sensitivity of OC cells through PLK1.
Resveratrol Inhibits Zinc Deficiency-Induced Mitophagy and Exerts Cardioprotective Effects
Authors: Wang Pei , Yang Ying , Guo Jiabao , Ma Tingting , Hu Youcheng , Huang Luyao , He Yonggui , Xi Jinkun 
Published: April 2023

Abstract
Resveratrol (Res) has cardioprotective, anti-inflammatory, anti-aging and antioxidant effects; however, its mechanism remains unclear. Here we explored the protective effects of resveratrol on cardiomyocytes, focusing on the role of Zn2+ and mitophagy. Using the MTT/LDH assay, we found that addition of a zinc chelator TPEN for 4h induced mitophagy and significantly reduced cell viability, increased cytotoxicity and apoptosis in H9c2, while Res significantly inhibited these effects of TPEN. Similarly, Res inhibited TPEN-induced expression of mitophagy-associated proteins P62, LC3, PINK1, Parkin and TOM20. The mitophagy inhibitor 3-MA blocked the function of Res. At the same time, we found that Mfn2 siRNA could reverse the inhibition of mitophagy by Res through AMPK (adenosine 5'-monophosphate (AMP)-activated protein kinase) and prevent the effect of the mitochondrial permeability transition pore (mPTP) opening. Thus, our data suggest that Res can exert mitochondrial protection by inhibiting mitophagy and preventing mPTP opening through AMPK-Mfn2 axis in myocardial cells.
Survival of Prey-Predator System in a Contaminant Environment
Authors: Makwana Kavita , A. Raveendra Babu , Misra O.P. , Jadon B.P.S. 
Published: April 2023

Abstract

The survival of prey predator food chain model in a toxin or contaminant environment is considered and discussed in this paper. The mathematical model is formulated with the help of nonlinear ordinary differential equations. Mathematical equations assume that the growth of prey species is negatively impacted by organisms and environmental toxins. The mathematical model is analysed by considering the Jacobian matrix and positive definite functions. The analytical conditions are supported by the numerical simulations and verify them in the bounded region.
Mathematics Subject Classification (2000) 93A30 · 92D40 · 34D20
Survival benefit of radiotherapy and nomogram for patients with primary tracheal malignant tumors: A Propensity Score-Matched SEER Database Analysis
Authors: Zheng Zhen , Du Zhennan , Fang Zhongjie , Shi Yunbin , Chen Xue , Jin Ming , Liu Kaitai 
Published: April 2023

Abstract
Purpose: The purpose of this study was to conduct a matched pair analysis to assess the impact of radiotherapy (RT) on patients with malignant tracheal tumors using the Surveillance, Epidemiology, and End Results (SEER) database. Additionally, a predictive nomogram was developed for patients with malignant tracheal tumors.
Methods: Propensity Score Matching (PSM) was used to minimize bias between the RT and no-RT groups. We utilized both univariate and multivariate Cox proportional hazards regression analyses to identify independent prognostic factors for patients and subgroups. We developed a novel nomogram and evaluated its results using the C-index.
Results: A total of 648 patients between 1975 and 2019 were included, and 160 patients in RT were 1:1 propensity score-matched with no-RT. The independent prognostic factors for patients with tracheal malignant tumors were surgery, marital status, disease extension, pathology, and age. The independent risk factors for patients without sur-gery included RT and disease extension. The C-index confirmed that the nomogram accurately predicted the prognosis of patients with tracheal malignant tumors.
Conclusions: Our findings suggest that RT may provide a survival benefit for tracheal cancer patients who did not undergo surgery. The nomogram can be a useful tool for predicting prognosis in patients with tracheal malignant tumors.
Pregnancy and Vestibular Challenges: A narrative review
Authors: Madrigal Jorge , Castillo-Bustamante Melissa , Moreno Andrea 
Published: April 2023

Abstract
Pregnancy includes several physical, hormonal, and psychological changes from conception to labor. The vestibular system is also affected during this life cycle and several challenges in patients who present vertigo or vestibular disorders during this time still being unregistered and there is a lack of information about how the vestibular system is affected during pregnancy, clinical and physiological correlation, and the expected results of vestibular testing in this population. Herein, we performed a review of expected physiological, clinical and vestibular testing results in pregnant patients to get the deepest understanding of the vestibular phenomenon during this time.
Multilateral development banks investment behaviour in water and sanitation: Findings and lessons from 60 years of investment projects in Africa and Asia
Authors: Heidler Andri , Nesi Muhil , Nikiema Josiane , Lüthi Christoph 
Published: April 2023

Abstract

Multilateral development banks (MDBs) play a pivotal role in financing water and sanitation infrastructure projects and thus have a major impact on the development of basic services. Although information about the MDBs' investments is publicly available, it is dispersed and not easily comparable. A comprehensive compilation of MDBs' water and sanitation investments has long been lacking. To address this gap, we assess water and sanitation financing by the three MDBs most relevant to Africa and Asia between 1960 and 2020: the World Bank, the African Development Bank, and the Asian Development Bank. We compile a new dataset by drawing on 3,639 water and sanitation projects and assess territorial trends, technology choices, distribution of financial burdens, and reforms to institutional arrangements. We find that MDBs' investments align with changing patterns of urbanization and increasingly finance sanitation infrastructures including non-sewered technologies. However, our results also suggest that institutional reforms have addressed utility efficiency through investment in equipment and skills rather than through increased commercialization and private sector participation. The leverage effect of MDB investment on private financing is negligible, whereas co-financing from local governments dominates.
Spatial and temporal distributions of temperature and rainfall on tropical islands of Vietnam
Authors: Phan Thi Thanh Hang , Nguyen Hang Anh 
Published: April 2023

Abstract

This study presents the spatial-temporal distribution of temperature and rainfall on the tropical islands of Vietnam using observed data, and historical and future climate data extracted from the ACCESS-ESM1.5. Regarding spatial distribution, the average temperature increased from North to South while rainfall did not vary significantly. Regarding temporal distribution, this research employed the Mann–Kendall test at a 5% significance level to analyze the trend of climate change. According to the calculation result, only annual temperature tended to increase in all stations but at different rates. Other trends of climate change in maximum, temperature, minimum temperature, annual rainfall, and maximum 1-day rainfall are inconsistent and only found significant in islands with a long-observed period. Using 1970–2000 as the reference period with all R2 above 0.94, this research extracted and predicted climate trends in the period of 2021–2100 for areas above 1 km2 based on four scenarios which are SSP 1-2.6, SSP 2-4.5, SSP 3-7.0, and SSP 5-8.5. The projected maximum and minimum temperatures have shown increasing trends whereas the change in annual rainfall is not clear. The results of this study provide important implications for climate change adaptation scenarios and territorial planning of tropical islands.
Quality deterioration of an Indian urban water source near an open dumping site
Authors: Robert Sruthy , Luckins Nisha , Menon Ratish 
Published: April 2023

Abstract

In developing countries, the stress of drinking water is often due to the increase in population, and rivers are the most important source of water. In this study, the pollution of the Kadambrayar River, located in southern India, was evaluated. The river flows through major establishments in the city, and an open dumping site is located near its bank. The river was infested with water hyacinth, which is considered a bioindicator of pollution in water bodies. Sixteen water quality parameters were analyzed across eight sampling stations in the river and compared with the standard limits as per IS 10500:2012 and IS 2296:1992, WHO, ICMR. It was found that parameters such as DO, BOD, and Coliforms did not comply with the limits at any of the stations. The heavy metals were also analyzed for water and sediment samples, in which the concentrations of arsenic in water were seven times higher and chromium was 50 times higher than the national standard limit. Thus, it can be concluded that the quality of this drinking water source is declining abruptly, especially downstream near the dumpsite, affecting the ecosystem as well as human health when exposed to carcinogenic metals.
Review of the Application of PAT in the Pharmaceutical Continuous Crystallization
Process
Authors: Zhao Bing , Zang Hengchang , Zhong Liang , Ma Xiaobo , Wang Haowei , Zhang Hui , Li Lian 
Published: April 2023

Abstract:
As an important pharmaceutical process, crystallization greatly impacts the final product.
In recent years, the continuous crystallization process has attracted more attention from researchers,
with the promotion of continuous manufacturing (CM) by the Food and Drug Administration
(FDA). The continuous crystallization process has the advantages of high economic benefit, stable
and uniform quality, a short production cycle, and personalization. To carry out continuous crystallization,
some related process analytical technology (PAT) tools have become the focus of breakthroughs.
Infrared (IR) spectroscopy, Raman spectroscopy, and focused beam reflection measurement
(FBRM) tools have gradually become research hotspots due to their fast, non-destructive, and
real-time monitoring characteristics. This review compared the advantages and disadvantages of the
three technologies. Their applications in the upstream mixed continuous crystallization process, the
middle reaches of crystal nucleation and growth, and the process of the downstream refining were
discussed to provide corresponding guidance for the practice and further development of these three
technologies in the continuous crystallization process and promote the development of CM in the
pharmaceutical industry.
The Open, Randomized, Positive Control Clinical Trial of Guluronic Acid
(G2013) on SARS-CoV-2 Patients
Authors: Aghazadeh Zahra , Sanaee Delir Davod , Gholamrezaie Hamid Reza , Sadoughi Arezoo , Nezami Asl Amir , Noori Sanami Mehran , Mahdavi Gorabi Armita , Panahi Younes , Taeb Mahsa , Razavi Alireza , Rafia Sara , Naderiyan Zahra , Robat-Jazi Behrouz , Mirshafiey Abbas 
Published: April 2023

Introduction:
Recently, the coronavirus disease 2019 (COVID-19) infection, with a vast spectrum
of clinical and paraclinical symptoms has been a major health concern worldwide. Therapeutical
management of COVID-19 includes antiviral and anti-inflammatory drugs. NSAIDs, as the second-line
therapy, are often prescribed to relieve the symptoms of COVID-19. The a-L-guluronic acid (G2013) is a
non-steroidal patented (PCT/EP2017/067920) agent with immunomodulatory properties. This study investigated
the effect of G2013 on the outcome of COVID-19 in moderate to severe patients.

Methods:
The disease’s symptoms were followed up during hospitalization and for 4 weeks postdischarge
in G2013 and control groups. Paraclinical indices were tested at the time of admission and
discharge. Statistical analysis was performed on clinical and paraclinical parameters and ICU admission
and death rate.

Results:
The primary and secondary outcomes indicated the efficiency of G2013 on COVID-19 patients’
management. There were significant differences in the duration of improvement of fever,
coughing, fatigue/malaise. Also, a comparison of paraclinical indices at the time of admission and discharge
showed significant change in prothrombin, D-dimer, and platelet. As the main findings of this
study, G2013 significantly decreased the percentage of ICU admission (control:17 patients, G2013:1
patient) and death (control: 7 cases, G2013:0).

Conclusion:
These results conclude that G2013 has sufficient potential to be considered for moderate
to severe COVID-19 patients, can significantly reduce the clinical and physical complications of this
disease, has a positive effect on modulating the coagulopathy process, and aids in saving lives.