bluuebunny/crossref_metadata_2025_split huggingface dataset:
The different predictive value of mean platelet volume-to-lymphocyte ratio for postoperative recurrence between non-muscular invasive bladder cancer patients treated with intravesical chemotherapy and intravesical chemohyperthermia
Authors: Wang Chengbo , Jin Wenjun , Ma Xiaodong , Dong Zhilong 
Published: January 2023

IntroductionThe inflammatory response plays a potential role in postoperative recurrence in patients with non-muscular invasive bladder cancer (NMIBC). We aimed to investigate whether platelet-to-lymphocyte ratio (PLR), mean platelet volume to lymphocyte ratio (MPVLR), and the systemic immune-inflammatory index (SII) have prognostic values in NMIBC treated with conventional intravesical chemotherapy or intravesical Chemohyperthermia (CHT) and the differences between them.Materials and methodsA retrospective cohort study was conducted on 222 patients with NMIBC treated with Intravesical Chemotherapy or Intravesical CHT between January 2016 and December 2020. Within a week before surgery, PLR, MPVLR, and SII were determined based on routine blood settling. The optimal cutoff value of each index was determined using the receiver operating characteristic curve, and various groups were categorized accordingly. The factors influencing the prognosis of NMIBC patients receiving various treatments were investigated using the Kaplan- Meier survival curve and the Cox regression model.Results69 cases (46.3%) in the gemcitabine (GEM) group had tumor recurrence and 19 (12.8%) of them progressed to muscle-invasive bladder cancer (MIBC) or got metastasis, while 19 cases (26.0%) in the CHT group recurred and 2 (2.7%) progressed. Elevated PLR, MPVLR, and SII were associated with higher recurrence rates in the GEM group. Meanwhile, PLR and MPVLR were the independent risk factors. While in the CHT group, high PLR and SII were related to postoperative recurrence and none of them were independent risk factors.ConclusionThe preoperative clinical inflammatory indexes PLR, SII, and MPVLR have certain predictive value for the postoperative recurrence-free survival (RFS) in NMIBC patients treated with intravesical chemotherapy while PLR and SII can predict the prognosis of NMIBC patients treated with intravesical CHT, which indicates that intravesical CHT may stop tumor recurrence by influencing the effect of mean platelet volume on tumor growth through some unknown mechanisms.
Plasma metabolomics, lipidomics and cytokinomics profiling predict disease recurrence in metastatic colorectal cancer patients undergoing liver resection
Authors: Costantini Susan , Di Gennaro Elena , Capone Francesca , De Stefano Alfonso , Nasti Guglielmo , Vitagliano Carlo , Setola Sergio Venanzio , Tatangelo Fabiana , Delrio Paolo , Izzo Francesco , Avallone Antonio , Budillon Alfredo 
Published: January 2023

PurposeIn metastatic colorectal cancer (mCRC) patients (pts), treatment strategies integrating liver resection with induction chemotherapy offer better 5-year survival rates than chemotherapy alone. However, liver resection is a complex and costly procedure, and recurrence occurs in almost 2/3rds of pts, suggesting the need to identify those at higher risk. The aim of this work was to evaluate whether the integration of plasma metabolomics and lipidomics combined with the multiplex analysis of a large panel of plasma cytokines can be used to predict the risk of relapse and other patient outcomes after liver surgery, beyond or in combination with clinical morphovolumetric criteria.Experimental designPeripheral blood metabolomics and lipidomics were performed by 600 MHz NMR spectroscopy on plasma from 30 unresectable mCRC pts treated with bevacizumab plus oxaliplatin-based regimens within the Obelics trial (NCT01718873) and subdivided into responder (R) and non-R (NR) according to 1-year disease-free survival (DFS): ≥ 1-year (R, n = 12) and &lt; 1-year (NR, n = 18). A large panel of cytokines, chemokines, and growth factors was evaluated on the same plasma using Luminex xMAP-based multiplex bead-based immunoassay technology. A multiple biomarkers model was built using a support vector machine (SVM) classifier.ResultsSparse partial least squares discriminant analysis (sPLS-DA) and loading plots obtained by analyzing metabolomics profiles of samples collected at the time of response evaluation when resectability was established showed significantly different levels of metabolites between the two groups. Two metabolites, 3-hydroxybutyrate and histidine, significantly predicted DFS and overall survival. Lipidomics analysis confirmed clear differences between the R and NR pts, indicating a statistically significant increase in lipids (cholesterol, triglycerides and phospholipids) in NR pts, reflecting a nonspecific inflammatory response. Indeed, a significant increase in proinflammatory cytokines was demonstrated in NR pts plasma. Finally, a multiple biomarkers model based on the combination of presurgery plasma levels of 3-hydroxybutyrate, cholesterol, phospholipids, triglycerides and IL-6 was able to correctly classify patients by their DFS with good accuracy.ConclusionOverall, this exploratory study suggests the potential of these combined biomarker approaches to predict outcomes in mCRC patients who are candidates for liver metastasis resection after induction treatment for defining personalized management and treatment strategies.
Development and validation of the Ibadan Simplified Developmental Screening chart
Authors: Lagunju I. A. , Adeniyi Y. , Orimadegun A. E. , Fernandez-Reyes D. 
Published: January 2023

BackgroundDevelopmental assessment remains an integral part of the routine evaluation of the wellbeing of every child. Children in resource-poor countries are not routinely assessed for signs of developmental delay and developmental disorders are frequently overlooked. A major gap exists in the availability of culturally appropriate and cost-effective developmental screening tools in many low and middle income countries (LMICs) with large populations.ObjectiveTo bridge the existing gap, we describe the process of the development and validation of the Ibadan Simplified Developmental Screening (ISDS) chart, for routine developmental screening in Nigerian children.MethodsWe developed an item pool across 4 domains of development namely, the gross motor, vision-fine motor, communication and socio-behavioural domains. The ISDS chart consists of 3–4 item questions for each domain of development, and responses are to be provided by the caregiver. Each chart is age-specific, from 6 weeks to 12 months. A total score derived from the summation of the scores in each domain are plotted on the ISDS scoring guide with a pass or fail score. Each child was evaluated by the Ages and Stages Questionnaire as the standard.ResultsA total of 950 infants; 453 males and 497 females were enrolled. The estimates of internal consistency between the two instruments ranged between 0.7–1.0. Using the ASQ as the gold standard, the ISDS chart demonstrated a sensitivity of 98.8%, 78.4% and 99.7% in the gross motor, communication and the social and emotional domains respectively, for detecting infants who might require further assessment for developmental delays.ConclusionThe indigenous tool fills a major gap in the need for cost-effective interventions for developmental monitoring in LMICs. Future work should include the deployment of the tool in the wider population, using digital health approaches that could underpin policy making in the region.
A review of health—related quality of life issues in children suffering from certain key otolaryngological illnesses
Authors: Chmielik Lechosław Paweł , Mielnik–Niedzielska Grażyna , Kasprzyk Anna , Niedzielski Artur 
Published: January 2023

BackgroundThe health—related quality of life (HRQoL) concept is nowadays increasingly and more broadly used for helping evaluate the effectiveness of medical treatment, superseding the earlier “quality of life” approach. The HRQoL concept likewise applies to otolaryngology and this narrative review study is focused on HRQoL outcomes in four key childhood otolaryngological diseases as reported in the literature.Study aimTo retrospectively evaluate the literature on measuring HRQoL in children suffering from selected otolaryngological illnesses, during treatment.Materials and MethodsPublished studies/case reports were searched for in Medline, PubMed, Web of Science, Scopus and ORCID on the quality of life based on paediatric patient questionnaires, whether completed by subjects themselves or by their parents (by proxy). The following key words were used: health quality of life, otolaryngology/ENT, pediatrics/paediatrics. Studies before 1999 were omitted because hitherto, the “quality of life” had been imprecisely defined thus rendering any subsequent comparisions problematic.ResultsHRQoL scores and well-being were found to significantly deteriorate in child patients suffering from four important otolaryngological disorders: chronic sinusitis, nasal septum deviation, adenoid hypertrophy and hearing disease. The main problems found were infection, inflammation, disruption to family life and child-parental interaction, fitness-related issues, reduced ENT patencies and apnea.ConclusionsThe HRQoL appears to significantly deteriorate in children suffering from otolaryngological diseases. Further such studies are needed for other ENT diseases.
Screening and identification of genes associated with flight muscle histolysis of the house cricket Acheta domesticus
Authors: Lu Ying , Wang Zizhuo , Lin Fei , Ma Yuqing , Kang Jiangyan , Fu Yuying , Huang Minjia , Zhao Zhuo , Zhang Junjie , Chen Qi , Ren Bingzhong 
Published: January 2023

Introduction: Flight muscle histolysis, as an important survival strategy, is a widespread phenomenon in insects and facilitates adaptation to the external environment in various insect taxa. However, the regulatory mechanism underlying this phenomenon in Orthoptera remains unknown.Methods: In this study, the flight muscle histolysis in the house cricket Acheta domesticus was investigated by transcriptomics and RNA interference.Results: The results showed that flight muscle histolysis in A. domesticus was standard and peaked within 9 days after eclosion of adult crickets, and there was no significant difference in the peak time or morphology of flight muscle histolysis between males and females. In addition, the differentially expressed genes between before and after flight muscle histolysis were studied, of which AdomFABP, AdomTroponin T and AdomActin were identified as candidate genes, and after injecting the dsRNA of these three candidates, only the downregulated expression of AdomFABP led to flight muscle histolysis in A. domesticus. Furthermore, the expression level of AdomFABP was compared between before and after flight muscle histolysis based on RT-qPCR.Disscussion: We speculated that AdomFABP might play a role in the degradation of flight muscle by inhibiting muscle development. Our findings laid a molecular foundation for understanding the flight muscle histolysis.
Cold tolerance strategy and cryoprotectants of Megabruchidius dorsalis in different temperature and time stresses
Authors: Chen Si-Yu , Zhao Ru-Na , Li You , Li He-Ping , Xie Ming-Hui , Liu Jian-Feng , Yang Mao-Fa , Wu Cheng-Xu 
Published: January 2023

The honey locusts (genus Gleditsia) are a genus of high-value trees in Asia. Seed beetle, Megabruchidius dorsalis (Fåhraeus) (Col.: Chrysomelidae: Bruchinae), is a Gleditsia oligophagous pest that causes severe yield reduction. To understand the cold tolerance of M. dorsalis adults, this study investigated its cold tolerance strategy and the influence of low temperatures on its physiology and biochemistry. The low-temperature treatments were divided into three groups: long-term temperature acclimation (Group 1; 15°C, or 20°C, or 25°C, or 28°C [control check, CK] for 10 days), short-term low-temperature exposure (Group 2; 0°C or 4°C for 2 h), and long-term low-temperature induction (Group 3; 0°C or 4°C for 1, 3, or 5 d). The supercooling point (SCP; temperature at which spontaneous nucleation and ice lattice growth begin), freezing point (FP; temperature at which insect fluids freeze), low lethal temperature (LLT; temperature at which all individuals are killed), water, lipid, glycerol, and total sugars contents were measured under different temperature stresses. The results showed that M. dorsalis adults were a freeze-avoidant species. The SCP and LLT at 28°C were −10.62°C and −19.48°C, respectively. The SCP and FP of long-term temperature acclimation (15°C, or 20°C, or 25°C) were significantly lower than that of the control group (28°C). The water content of the long-term low temperature induction (0°C) group was significantly lower than that of the control group. The lipid and glycerol content in the acclimated group at 20°C and 25°C were significantly higher than in the control group. M. dorsalis adults may maintain their biofluids in a supercooled state via cryoprotectant accumulation and cryoprotective dehydration to prevent ice nucleation. This study provides a theoretical basis for future research on overwintering and potential distribution and related prediction of M. dorsalis adults.
Methane dynamics from a mixed plantation of north China: Observation using closed-path eddy covariance method
Authors: Yuan Wenwen , Huang Hui , Zhang Jinsong , Meng Ping , Li Jun , Wu Tonggui , Zhou Fang , Pan Qingmei 
Published: January 2023

Although an important greenhouse gas, methane flux in hilly forest ecosystems remains unclear. By using closed-path eddy covariance systems, methane flux was measured continuously from 2017 to 2019 in a mixed plantation in the Xiaolangdi area of the Yellow River in North China. The methane flux footprint and its diurnal and monthly variations were analysed, and its characteristics on rainy days are discussed. The results showed that: (a) the observation data were reliable with good spatial representation (b) The methane flux in the mixed plantation ecosystem had obvious diurnal and seasonal variations: the monthly average diurnal variation of the methane flux had a single-peak; the methane flux value was source in the daytime and sink at night. The daily mean maximum value of methane flux in growing season was lower than that in non-growing season with the maximum value appearing in March, and the minimum value in October. (c) The forest is an atmospheric CH4 source with the annual emission in 2017 of (3.31 g C·m-2·year -1) &gt;2019 (2.94 g C·m-2·year-1) &gt;2018 (2.81 g C·m-2·year -1), and the main influencing factor was precipitation. Rainfall affected CH4 flux with a lag period of approximately three days. Rainfall also changed the balance of CH4 flux between sink or source according to precipitation intensity and frequency.
Maintenance of postharvest storability and overall quality of ‘Jinshayou’ pummelo fruit by salicylic acid treatment
Authors: Huang Qiang , Huang Lulu , Chen Jinyin , Zhang Yajie , Kai Wenbin , Chen Chuying 
Published: January 2023

IntroductionThe loss of postharvest storability of pummelo fruit reduces its commodity value for long run. To maintain its storability, the effects of postharvest dipping treatment by salicylic acid (SA) with different concentrations (0, 0.1, 0.2, or 0.3%) were investigated on pummelo fruit (Citrus maxima Merr. cv. Jinshayou) during the room temperature storage at 20 ± 2°C for 90 d.Results and discussionAmong all treatments, pre-storage SA treatment at 0.3% demonstrated the most significant ability to reduce fruit decay incidence, decrease weight loss, delay peel color-turned process, and inhibit the declines in total soluble solids (TSS) as well as titratable acid (TA) content. The increases in electrolyte leakage, hydrogen peroxide (H2O2), and malondialdehyde (MDA) content of the 0.3% SA-treated pummelo fruit were reduced compared to the control (dipped in distilled water). Pummelo fruit treated with 0.3% SA exhibited the most outstanding ability to excess reactive oxygen species (ROS) accumulation, as evidenced by promoted the increases in glutathione (GSH), total phenolics and flavonoids contents, delayed the AsA decline, and enhanced the activities of antioxidant enzymes and their encoding genes expression.ConclusionPre-storage treatment dipped with SA, particularly at 0.3%, can be used as a useful and safe preservation method to maintain higher postharvest storability and better overall quality of ‘Jinshayou’ pummelo fruit, and thus delaying postharvest senescence and extend the storage life up to 90 d at room temperature.
Adolescents at risk of eating disorders: The mediating role of emotional distress in the relationship between differentiation of self and eating disorders
Authors: Peleg Ora , Boniel-Nissim Meyran , Tzischinsky Orna 
Published: January 2023

IntroductionAdolescents may feel dissatisfied with their bodies, which may lead to a risk of eating disorders (EDs) due to several factors, with emotional distress being one of the most important. Evidence suggests that family might be one of the most significant factors that may increase or decrease emotional distress. An important family pattern found to contribute to mental and physical health is the differentiation of self (DoS). The primary purpose of the current study was to map the complex relationships between DoS, emotional distress, and EDs among adolescents. We hypothesized that emotional distress would mediate the relationship between DoS and the risk of EDs among adolescents. Moreover, based on findings indicating a higher risk of EDs among females, we expected sex differences in the research indices and the mediation model.MethodsThe sample included 194 non-clinical adolescents (mean age 15.15; mean BMI 21.66). Preliminary analyses examined differences between males and females using t-tests. In addition, Pearson correlations were run to assess the association between background variables and the study metrics among males and females. To examine the mediation effect, we ran SEM.ResultsDue to a sex moderation effect, two mediation models were run (SEM), one for females and one for males. Results indicated that emotional distress partially mediated the relationships between DoS and the risk of EDs. In addition, sex differences were found in the mediated indices, showing that among female adolescents, perfectionism is the only dimension of EDs that was associated with DoS through the mediation of emotional distress. While the relationship between emotional distress and the risk of EDs is well documented.ConclusionsIt is concluded that high DoS may reduce emotional distress, which may, in turn, decrease the risk of EDs. In addition, the results enable an in-depth understanding of specific risk factors of EDs that characterize each sex.
The motive of competition but not courtship positively correlates with self-reported use of aggressive humor: A critical test of the contests- vs. mate-choice hypotheses
Authors: Duarte Brent , Zhang Jinguang 
Published: January 2023

IntroductionThe use of aggressive humor (e.g., teasing, schadenfreude, and sarcasm) is a spiteful behavior because it inflicts costs on both others and the self. To explain the existence of this spiteful behavior, two hypotheses derived from sexual selection theory—namely Mate-Choice and Contests—posit that the use of aggressive humor helps one attract mates or repel competitors. Both hypotheses have merit, but extant data are unable to discriminate between them.MethodsWe critically tested those two hypotheses with a survey study that measured 509 U.S. MTurkers’ self-reported tendencies to use aggressive (and other types of) humor, the motives to engage in competition and courtship, and the Dark-Triad personality traits. The final sample was N = 439.ResultsWe found that (1) the motive of competition but not courtship positively and significantly correlated with the self-reported tendency to use aggressive humor. (2) Subclinical psychopathy—a personality trait positively associated with competition—mediated the correlation between the motive of competition and self-reported use of aggressive humor. These results were held in both female and male respondents.DiscussionOur findings favored the Contests Hypothesis and helped reveal the psychological mechanism that generates the use of aggressive humor as a form of verbal aggression and spiteful behavior.
Prevalence and correlates of subjective cognitive concerns in Australian university students during the COVID-19 pandemic
Authors: Bird Laura J. , McCabe Melinda , Lim Yen Ying , Cornish Kim 
Published: January 2023

IntroductionCoronavirus (COVID-19) instigated unprecedented global effects on healthcare systems, economies, employment, education, travel, and social lives. In addition to increased mental health challenges, pandemic restrictions have triggered emerging cognitive concerns. University students are at particularly high risk of adverse lockdown-related effects, yet despite the substantial adaptions to learning necessitated by COVID-19, limited research has so far focused on the cognitive consequences of the pandemic among university students. This study aimed to comprehensively examine the nature, prevalence, and correlates of subjective cognitive concerns among 972 students (Median age = 22 years, 70% female) enrolled at Monash University, Australia, in December 2020.MethodsStudents completed the online THRIVE@Monash survey, 5 weeks following prolonged lockdown in Melbourne. Using group comparisons and hierarchical binary logistic regression analyses, we examined associations between demographic and enrolment characteristics, COVID-19-related experiences and impacts (author-developed questions), self-reported anxiety and depression symptoms (PROMIS Anxiety and Depression scales), and students’ perceived changes in everyday cognitive functions (author-developed questions).ResultsOver 60% of students reported subjective cognitive concerns (SCCs). After controlling for anxiety and depression symptoms, students reporting more SCCs were more likely to be younger, from White/European ethnic backgrounds, and in their first year of undergraduate study. No differences in SCCs were found between male and female students. Greater worry, anxiety, or stress related to COVID-19 (e.g., infection, leaving the house, hygiene and exposure prevention, impact on physical and mental health), and time spent reading or talking about COVID-19, were generally not associated with SCCs after controlling for anxiety and depression symptoms.DiscussionThese findings highlight vulnerable subgroups of students who might benefit from regular monitoring, education, and interventions to support their cognitive health during the pandemic and beyond. In addition, cognitive concerns may provide additional insight into mental health problems among students, and emphasize the importance of understanding factors that impact students’ long-term academic and career success.