bluuebunny/crossref_metadata_2025_split huggingface dataset:
Area‐time efficient point multiplication architecture on twisted Edwards curve over general prime field GF(p)
Authors: Javeed Khalid , El‐Moursy Ali 
Published: July 2023

AbstractElliptic curve point multiplication is the main primitive required in almost all security schemes using elliptic curve cryptography (ECC). It is the leading computationally intensive operation that sets the overall performance of the associated cryptosystem. This work presents a highly novel area–time efficient elliptic curve point multiplier over a general prime field
. It is based on an efficient radix‐23 parallel
multiplier, which performs a
‐bit
multiplication in
clock cycles. On the system level, the twisted Edwards curves with unified point addition using projective coordinates are adopted, where an efficient scheduling technique is presented to schedule several
operations on deployed modular arithmetic units. Due to the introduced optimization at different stages of the design, latency, hardware resource requirement, and total clock cycle count are reduced significantly. Synthesis, and implementation of the proposed design over different Xilinx FPGA platforms are completed using the Xilinx ISE Design Suite tool for key sizes of 192, 224, and 256 bits. The 256‐bit Xilinx Virtex‐7 FPGA implementation reveals that it completes a single point multiplication operation in 0.8 ms and occupies 6.7K FPGA slices in a clock cycle count of 132.2K. It produces significantly better area–time product and throughput per slice than the contemporary designs. The proposed design also has the potential to counter simple power analysis and timing attacks. Thus, it is an elegant solution to develop ECC‐based cryptosystems for applications, where both speed and hardware resource consumption are important.
Spatiotemporal epizootiology of chronic wasting disease in Wisconsin deer
Authors: Samuel Michael D. 
Published: July 2023

AbstractChronic wasting disease (CWD) is a fatal neurological disease of cervids caused by a misfolded protein with no vaccines or other cures to prevent infection and death. In the past decade, CWD has been recognized as one of the 10 most important challenges facing wildlife management. This paper evaluates the temporal and spatial patterns of CWD prevalence in southern Wisconsin white‐tailed deer during the past 20 years. In most CWD areas, prevalence progresses from introduction to enzootic equilibrium in 15–20 years. In some monitoring areas, the disease grows at a much slower rate and remains below the equilibrium levels. Outbreaks are characterized by four distinct epizootic stages. Disease establishment (Stage 1) depends on the distance from a CWD focus. High rates of incidence and prevalence growth (Stage 2) are followed by slower growth as the relative number of susceptible deer declines (Stage 3). The rate of prevalence increase over time is higher in more forested ecoregions and in males (0.48 vs. 0.43) but similar in females (0.43 vs. 0.37) and yearlings (0.44 vs. 0.39). Habitat features, acting as surrogates for deer behavior and contact, may affect the rate of prevalence growth at a landscape (ecoregion) scale. Additionally, prevalence may be affected by deer management practices that favor higher deer abundance and more mature males. Finally, enzootic equilibrium (Stage 4) is higher in males (0.5), followed by females (0.36) and then yearlings (0.26). These equilibrium prevalence levels are high enough to have significant population impacts, reduce the abundance of mature males, and facilitate CWD spread by infected yearlings. Epizootic patterns suggest that CWD transmission has been frequency‐dependent and primarily driven by direct contact with infected deer. Evidence for a meaningful change in the epizootic pattern from a 10‐year management program to reduce deer abundance is lacking. The trajectory of CWD dynamics in Wisconsin suggests rapid growth in regional prevalence following introduction and increased spread across the landscape.
Three‐dimensional simulation of the acidizing process under different influencing factors in fractured carbonate reservoirs
Authors: Guo Anbang , Tang Xuhai , Qiao Jiangmei , Zhou Linbo , Luo Pandeng 
Published: July 2023

AbstractMatrix acidizing is widely used to enhance oil/gas production in the exploitation of carbonate reservoirs. In this work, a three‐dimensional (3D) hydro‐chemical‐thermal (H‐C‐T)‐coupled model was presented to improve the understanding of the acidizing process. The influence of different influencing factors was analyzed, especially the coupling effect of natural fractures and in situ stress. With the increase in acid injection concentration, the minimum pore volume of acid required for breakthrough (PVBT) decreases. The optimal injection rate and the minimum PVBT increase with increasing initial reservoir temperature. With the increasing initial reservoir permeability, the minimum PVBT increases. With the increasing initial reservoir pore diameter and specific surface area, the minimum PVBT and the optimal acid injection rate increase. When the fracture direction is perpendicular to the direction of the maximum principal stress, the fracture apertures decrease with the increase of the maximum principal stress, which leads to an increase in PVBT and wider paths of wormholes. Lastly, the present H‐C‐T‐coupled model was applied in the context of Tahe reservoir exploitation, which shows that optimizing the acid injection rate is able to enhance the connection between wellbores and natural caves.
Classification of multiple power quality disturbances based on continuous wavelet transform and lightweight convolutional neural network
Authors: Xi Yanhui , Li Xule , Zhou Feng , Tang Xin , Li Zewen , Zeng Xiangjun 
Published: July 2023

AbstractAiming at the problems of noise interference and too many network parameters for power quality disturbances' (PQDs') classification based on deep learning, the lightweight convolutional neural network combining maximum likelihood Kalman filter and continuous wavelet transform is proposed. In this proposed method, the disturbed PQD signals are denoised by maximum likelihood Kalman filter, and then the denoised PQDs are converted to time‐frequency diagrams, which can provide rich time and frequency domain information, and finally the lightweight convolution neural network is used for automatically extracting and classifying multiple PQDs. To verify the effectiveness and superiority of the proposed method, a variety of PQDs were tested under different noise levels, the experiment results indicate that the average classification accuracy can reach more than 99% even in the case of 10 dB noise. Compared with the existing classification methods, the accuracy and noise immunity ability are improved. Additionally, the proposed method has decided advantages, as evidenced by its low parameter count of 0.73M and short average test time with only 0.7 ms.
Notes on Potentilla (Rosaceae) of Altai. 10. New section from Mongolia
Authors: Kechaykin Alexey , Skaptsov Mikhail , Vaganov Alexey , Sinitsyna Tatiana , Zaikov Vladimir , Baasanmunkh Shukherdorj , Shmakov Alexander 
Published: July 2023

AbstractA new section Salsuginosae in the genus Potentilla is described based on morphological characteristics and ecological confinement. It contains P. laevipes and P. laevissima, two rarest endemics of the Altai Mountainous Country, known from collections only from Western Mongolia. For the representatives of the new section, for the first time, data on the genome size and chromosome numbers were revealed, information on morphology and distribution was supplemented, and a conservation status was proposed. Photos of P. laevissima in its natural habitat are provided, for the first time. Most of the studied herbarium samples were scanned and are provided in the Global Biodiversity Information Facility (GBIF.org).
Mannose‐rich exopolysaccharide from Agaricus sinodeliciosus var. Chaidam: Purification, chemical characterization, and neuroprotective activity
Authors: Lu Hongyun , Chen Jicheng , Shi Ying , Wang Wei , Chen Qihe 
Published: July 2023

AbstractAmyloid β (Aβ) aggregation is a hallmark of Alzheimer's disease (AD). Searching for compounds that attenuate Aβ aggregation could uncover novel prevention for AD. Herein, an exopolysaccharide (EPS)‐2 was purified from the fermentation broth of Agaricus sinodeliciosus var. Chaidam. Morphology characterization, circular dichroism spectroscopy, and molecular docking demonstrated that EPS‐2 inhibited oligomer formation and remodeled the conformational conversion of Aβ1‐42, thus reducing the cytotoxicity and oxidative stress induced by Aβ1‐42 oligomers in vitro. Structural characterization revealed that the neuroprotective EPS‐2 with an average molecular weight of 18 kDa consisted of mannose, galactose, and a small proportion of rhamnose, glucose, fucose, ribose, glucuronic acid, and galactosamine. Glycosidic linkage and nuclear magnetic resonance analysis suggested that EPS‐2 has a backbone of →1)‐D‐Galp‐(6→, →1)‐D‐Manp‐(2, 6→, →1)‐D‐Galp‐(2→ and →1)‐t‐Manp with branched chains. Therefore, EPS‐2 was able to block Aβ1‐42 aggregation and reduced its neurotoxicity, and thus can be developed into a potential functional food ingredient for AD patients.
Development of an innovative minimally invasive primate spinal cord injury model: A case report
Authors: Niu Yong‐Min , Liu Jin‐Xiang , Qin Hao‐Yue , Liu Yi‐Fan , Huang Ni‐Jiao , Jiang Ji‐Li , Chen Yan‐Qiu , Chen Si‐Jing , Bai Tao , Yang Chang‐Wei , Cao Yu , Liu Sheng , Yuan Hao 
Published: July 2023

AbstractSpinal cord injury (SCI) animal models have been widely created and utilized for repair therapy research, but more suitable experimental animals and accurate modeling methodologies are required to achieve the desired results. In this experiment, we constructed an innovative dorsal 1/4 spinal cord transection macaque model that had fewer severe problems, facilitating postoperative care and recovery. In essence, given that monkeys and humans share similar genetics and physiology, the efficacy of this strategy in a nonhuman primate SCI model basically serves as a good basis for its prospective therapeutic use in human SCI.
Gut microbiota in heart failure and related interventions
Authors: Chen An‐Tian , Zhang Jian , Zhang Yuhui 
Published: July 2023

AbstractHeart failure (HF) is a sophisticated syndrome with structural or functional impairment of ventricular filling or ejection of blood, either causing symptoms and signs or being asymptomatic. HF is a major global health issue affecting about 64.3 million people worldwide. The gut microbiota refers to the complex ecosystem of microorganisms, mainly bacteria, in the gut. Studies have revealed that the gut microbiota is associated with many diseases ranging from neurodegenerative diseases to inflammatory bowel disease and cardiovascular diseases. The gut hypothesis of HF suggests that low cardiac output and systemic circulation congestion would cause insufficient intestinal perfusion, leading to ischemia and intestinal barrier dysfunction. The resulting bacterial translocation would contribute to inflammation. Recent studies have refined the hypothesis that changes of metabolites in the gut microbiota have a close relationship with HF. Thus, the gut microbiota has emerged as a potential therapeutic target for HF due to both its critical role in regulating host physiology and metabolism and its pivotal role in the development of HF. This review article aims to provide an overview of the current understanding of the gut microbiota's involvement in HF, including the introduction of the gut hypothesis of HF, its association with HF progression, the potential mechanisms involved mediated by the gut microbiota metabolites, and the impact of various interventions on the gut microbiota, including dietary interventions, probiotic therapy, fecal microbiota transplantation, antibiotics, and so on. While the gut hypothesis of HF is refined with up‐to‐date knowledge and the gut microbiota presents a promising target for HF therapy, further research is still needed to further understand the underlying mechanisms between gut microbiota and HF, the efficacy of these interventions, and contribute to the health of HF patients.
A novel online genomic counseling and variant interpretation certificate: Learning design, learning analytics, and evaluation
Authors: Macfadyen Leah P. , Austin Jehannine , Cao Ping , Cheng John , Cremin Carol , Duong Linda , Elliott Alison M. , Guimond Colleen , Lim Shur , Race Simone , Rajan‐Babu Indhu‐Shree , Richardson Anastasia , Wainstein Tasha , Zahir Farah , Birch Patricia H. 
Published: July 2023

AbstractIn this paper we describe the analysis, planning, design, development, implementation and evaluation of a new online Graduate Certificate in Genomic Counselling and Variant Interpretation (GCGCVI) at The University of British Columbia (UBC). Genetic counselling is now a prerequisite for diagnostic genomic testing in many countries, demanding that genetic counselling practitioners have up‐to‐the‐moment genomic counselling skills and knowledge. Current practitioners reported a desire for more training in this rapidly developing field: our international survey revealed substantial interest in online continuing education addressing themes such as testing and clinical bioinformatics, applied variant interpretation, evidence‐based genomic counselling, and other emerging genomic topics. However, our market analysis found no post‐graduate program globally that offered such training. To fill this gap, our oversight team of genetic counsellors and geneticists therefore guided development of curriculum and materials, and online learning specialists developed rigorous interactive asynchronous online graduate courses through collaboration with subject matter experts, following best practices in online learning design. Since launch in September 2020, we have gathered learner feedback using surveys and focus groups, and we have used learning analytics to understand how learners engaged with each other and with course materials. Together, these have helped us understand learner behaviour and guide the continuous process of design improvement to support the learning goals of this audience of professional learners. Our courses have been reviewed and approved by the UBC Faculty of Medicine, UBC Senate, and the Province of British Columbia Ministries of Advanced Education and Health, and assessed by the National Society of Genetic Counselors (NSGC, USA) and the Canadian Association of Genetic Counsellors (CAGC) to enable learners to receive North American continuing education credits. To date, 151 individuals from 18 countries have succeeded in one or more course and 43 have completed the entire certificate.
Use of Real‐Time Cine MRI to Assess the Respirophasic Variation of the Inferior Vena Cava—Proof‐of‐Concept and Validation Against Transthoracic Echocardiography
Authors: Bogaert Jan , Bekhuis Youri , Rosseel Thomas , Laveaux Stijn , Dausin Christophe , Voigt Jens‐Uwe , Claessen Guido , Dresselaers Tom ,   Pro@Heart Consortium
Published: July 2023

BackgroundIn clinical practice, the right heart filling status is assessed using the respirophasic variation of the inferior vena cava (IVC) assessed by transthoracic echocardiography (TTE) showing moderate correlations with the catheter‐based reference standard.PurposeTo develop and validate a similar approach using MRI.Study TypeProspective.Population37 male elite cyclists (mean age 26 ± 4 years).Field Strength/SequenceReal‐time balanced steady‐state free‐precession cine sequence at 1.5 Tesla.AssessmentRespirophasic variation included assessment of expiratory size of the upper hepatic part of the IVC and degree of inspiratory collapse expressed as collapsibility index (CI). The IVC was studied either in long‐axis direction (TTE) or using two transverse slices, separated by 30 mm (MRI) during operator‐guided deep breathing. For MRI, in addition to the TTE‐like diameter, IVC area and major and minor axis diameters were also assessed, together with the corresponding CIs.Statistical TestsRepeated measures ANOVA test with Bonferroni correction. Intraclass correlation coefficient (ICC) and Bland–Altman analysis for intrareader and inter‐reader agreement. A P value <0.05 was considered statistically significant.ResultsNo significant differences in expiratory IVC diameter were found between TTE and MRI, i.e., 25 ± 4 mm vs. 25 ± 3 mm (P = 0.242), but MRI showed a higher CI, i.e., 76% ± 14% vs. 66% ± 14% (P < 0.05). As the IVC presented a noncircular shape, i.e., major and minor expiratory diameter of 28 ± 4 mm and 21 ± 4 mm, respectively, the CI varied according to the orientation, i.e., 63% ± 27% vs. 75% ± 16%, respectively. Alternatively, expiratory IVC area was 4.3 ± 1.1 cm2 and showed a significantly higher CI, i.e., 86% ± 14% than diameter‐based CI (P < 0.05). All participants showed a CI >50% with MRI versus 35/37 (94%) with TTE. ICC values ranged 0.546–0.841 for MRI and 0.545–0.704 for TTE.ConclusionAssessment of the respirophasic IVC variation is feasible with MRI. Adding this biomarker may be of particular use in evaluating heart failure patients.Level of Evidence1Technical Efficacy Stage2
How genuine is your diversity climate? A new typology highlighting the emergence of specious diversity climates
Authors: Ward‐Bartlett Anna‐Katherine , Ravlin Elizabeth , Park Ji Eun 
Published: July 2023

SummaryResearch supports the notion that diversity climate (employees' perceptions of the extent to which fairness and elimination of discrimination are promoted within the work unit) can help the unit attain benefits—rather than detriments—from workforce diversity. However, the diversity climate literature rests substantially on a questionable assumption—that all unit members perceive the environment uniformly—which fails to account for the potential of individuals' distinct experiences in units. We introduce a new typology of diversity climates to address how individual and subgroup perceptions develop and aggregate to reflect an overall climate. This framework calls attention to specious diversity climates, in which a homogeneous population of employees agrees in their perceptions of a supportive diversity climate despite exclusion and/or otherwise unfair treatment of marginalized members. We explore the emergence process of each distinct climate type, explicating how perceptions aggregate to form a unit diversity climate that falls into one of five categories (i.e., genuinely supportive, speciously supportive, moderate/unsupportive, multimodal, or fragmented). We conclude with implications for theory and managerial practice.
Physicochemical, microbiological, and sensory properties of low‐lactose yogurt using Streptococcus thermophilus with high β‐galactosidase activity
Authors: Li Ling , Zhou Ling , Liu Xuemin , Gong Jinyan , Xiao Gongnian 
Published: July 2023

AbstractBACKGROUNDLactose maldigestion or intolerance affects a large number of individuals worldwide. If lactose is hydrolyzed by the β‐galactosidase enzyme during the fermentation process, lactose‐intolerant individuals can consume milk products without experiencing diarrhea, flatulence, or other symptoms.RESULTS AND CONCLUSIONWe isolated and characterized Streptococcus thermophilus, which exhibits high β‐galactosidase activity. This was then used as a starter culture with Lactobacillus delbrueckii subsp. bulgaricus in yogurt to determine the effects of different starter ratios and fermentation temperatures on its organoleptic and physical properties. The β‐galactosidase activity of the isolated strain was 2.60 units mg−1. The optimal temperature was 42 °C for St. thermophilus to acidify yogurt faster than at other temperatures and it was effective in hydrolyzing the lactose in the media and yogurt. The lactic acid bacteria (LAB) population in 37 °C fermented yogurt was higher than in the other samples, but the starters St. thermophilus and Lb. bulgaricus with a ratio of 2:1 used lactose more effectively than other sample ratios. The lactose content decreased significantly at 37 °C, where it was ~50% hydrolyzed. The acceptability of the sensory properties of yogurt was unaffected by relative lower fermentation temperatures (30 and 37 °C), despite using different ratios of St. thermophilus and Lb. bulgaricus as starter cultures. © 2023 Society of Chemical Industry.
Acceptability, feasibility and preliminary effectiveness of Picopulse for the treatment of melasma among Malaysian women: A pilot quasi‐experimental
Authors: Foo Chai Nien , Dewadas Hemaniswarri Dewi , Chin Boon Keat , Teoh Tean Chun , Ong Hong Keat , Lim Yang Mooi 
Published: July 2023

AbstractBackgroundWomen are greatly affected by melasma as compared to men and has a significant negative impact on their quality of life. Thus far, there are no well‐conducted trials for melasma in Malaysia.ObjectivesThis multicentre quasi‐experimental pilot study aims to determine the acceptability and feasibility of conducting a preliminary effectiveness trial for the Picopulse treatment effect on melasma severity and quality of life in Malaysian women.MethodsOutcome measures were collected from 32 participants aged 18–65 years old presenting dermal melasma with Fitzpatrick skin type III–V from OneDoc Skin Centres in Klang Valley, Malaysia at baseline, 2 weeks, and 4 weeks after intervention. All preliminary effectiveness analyses were performed under the terms of intention‐to‐treat.ResultsOverall, the average score of Short Assessment of Patient Satisfaction (SAPS) was 22.2 (SD = 4.8), this demonstrated that the treatment was satisfied and well‐accepted by all patients. The recruitment and retention rates were 48.48% and 71.88%, respectively. Twenty‐five out of 32 patients completed all 10 treatments (78.13%). There were significant mean differences in Melasma severity index (MSI) score reported with partial eta square at 0.79 (p < 0.0001), physician global assessment (PGA) with partial eta square at 0.89 (p < 0.0001), and melasma quality of life scale (MELASQoL) with partial eta square at 0.32 (p < 0.05), from baseline measurement to 4 weeks postintervention. The three most common temporary side effects were pain (M = 0.2, SD = 0.46), redness (M = 0.12, SD = 0.24), and dryness (M = 0.11, SD = 0.17), however, all adverse effects were well‐tolerated and resolved without any treatments.ConclusionsThese findings provide promising data that support the acceptability and feasibility for future full‐scale clinical studies. This study was registered with ClinicalTrials.gov (NCT04834167).