bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bronchoscopy using a head-mounted mixed reality device—a phantom study and a first in-patient user experience
Authors: Kildahl-Andersen Arne , Hofstad Erlend Fagertun , Sorger Hanne , Amundsen Tore , Langø Thomas , Leira Håkon Olav , Kiss Gabriel 
Published: June 2023

Background: Bronchoscopy for peripheral lung lesions may involve image sources such as computed tomography (CT), fluoroscopy, radial endobronchial ultrasound (R-EBUS), and virtual/electromagnetic navigation bronchoscopy. Our objective was to evaluate the feasibility of replacing these multiple monitors with a head-mounted display (HMD), always providing relevant image data in the line of sight of the bronchoscopist.Methods: A total of 17 pulmonologists wearing a HMD (Microsoft® HoloLens 2) performed bronchoscopy with electromagnetic navigation in a lung phantom. The bronchoscopists first conducted an endobronchial inspection and navigation to the target, followed by an endobronchial ultrasound bronchoscopy. The HMD experience was evaluated using a questionnaire. Finally, the HMD was used in bronchoscopy inspection and electromagnetic navigation of two patients presenting with hemoptysis.Results: In the phantom study, the perceived quality of video and ultrasound images was assessed using a visual analog scale, with 100% representing optimal image quality. The score for video quality was 58% (95% confidence interval [CI] 48%–68%) and for ultrasound image quality, the score was 43% (95% CI 30%–56%). Contrast, color rendering, and resolution were all considered suboptimal. Despite adjusting the brightness settings, video image rendering was considered too dark. Navigation to the target for biopsy sampling was accomplished by all participants, with no significant difference in procedure time between experienced and less experienced bronchoscopists. The overall system latency for the image stream was 0.33–0.35 s. Fifteen of the pulmonologists would consider using HoloLens for navigation in the periphery, and two would not consider using HoloLens in bronchoscopy at all. In the human study, bronchoscopy inspection was feasible for both patients.Conclusion: Bronchoscopy using an HMD was feasible in a lung phantom and in two patients. Video and ultrasound image quality was considered inferior to that of video monitors. HoloLens 2 was suboptimal for airway and mucosa inspection but may be adequate for virtual bronchoscopy navigation.
Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma
Authors: Farahmand Pooyeh , Gyuraszova Katarina , Rooney Claire , Raffo-Iraolagoitia Ximena L. , Jayasekera Geeshath , Hedley Ann , Johnson Emma , Chernova Tatyana , Malviya Gaurav , Hall Holly , Monteverde Tiziana , Blyth Kevin , Duffin Rodger , Carlin Leo M. , Lewis David , Le Quesne John , MacFarlane Marion , Murphy Daniel J. 
Published: June 2023

Hypothesis: Asbestos-driven inflammation contributes to malignant pleural mesothelioma beyond the acquisition of rate-limiting mutations.Methods: Genetically modified conditional allelic mice that were previously shown to develop mesothelioma in the absence of exposure to asbestos were induced with lentiviral vector expressing Cre recombinase with and without intrapleural injection of amosite asbestos and monitored until symptoms required euthanasia. Resulting tumours were examined histologically and by immunohistochemistry for expression of lineage markers and immune cell infiltration.Results: Injection of asbestos dramatically accelerated disease onset and end-stage tumour burden. Tumours developed in the presence of asbestos showed increased macrophage infiltration. Pharmacological suppression of macrophages in mice with established tumours failed to extend survival or to enhance response to chemotherapy.Conclusion: Asbestos-driven inflammation contributes to the severity of mesothelioma beyond the acquisition of rate-limiting mutations, however, targeted suppression of macrophages in established epithelioid mesothelioma showed no therapeutic benefit.
Prognostic value of pretreatment Controlling Nutritional Status score in esophageal cancer: a meta-analysis
Authors: Lv Jing , Chen Peirui , Wu Jianqiang , Hu Caihong 
Published: June 2023

Background and purpose: The association between the pretreatment Controlling Nutritional Status (CONUT) score and the prognosis of esophageal cancer patients remains unclear. The aim of this meta-analysis was to further elucidate the prognostic role of the pretreatment CONUT score in esophageal cancer based on current evidence.Methods: The PubMed, Embase, Web of Science and CNKI databases were searched up to 27 September 2022. The primary and secondary outcomes were overall survival (OS) and progression-free survival (PFS)/cancer-specific survival (CSS), and the hazard ratio (HR) and 95% confidence interval (CI) were pooled for analysis.Results: A total of 11 retrospective studies involving 3,783 participants were included. The pooled results demonstrated that a higher pretreatment CONUT score was significantly related to poor OS (HR = 1.82, 95% CI: 1.31–2.54, p &lt; 0.001), and subgroup analysis stratified by pathological type showed similar results. In addition, the pretreatment CONUT score was associated with poor PFS (HR = 1.19, 95% CI: 1.10–1.28, p &lt; 0.001) and CSS (HR = 2.67, 95% CI: 1.77–4.02, p &lt; 0.001).Conclusion: The pretreatment CONUT score was predictive of worse prognosis in esophageal cancer, and patients with a higher CONUT score showed worse survival.
Phenotypic and Genotypic Analysis of Antimicrobial Resistance of Commensal Escherichia coli from Dairy Cows’ Feces
Authors: Kerluku Maksud , Ratkova Manovska Marija , Prodanov Mirko , Stojanovska-Dimzoska Biljana , Hajrulai-Musliu Zehra , Jankuloski Dean , Blagoevska Katerina 
Published: June 2023

Commensal Escherichia coli has the potential to easily acquire resistance to a broad range of antimicrobials, making it a reservoir for its transfer to other microorganisms, including pathogens. The aim of this study was to determine the prevalence of resistant commensal Escherichia coli isolated from dairy cows’ feces. Phenotypic resistance profiles and categorization were determined by minimum inhibitory concentration (MIC) testing with the broth microdilution method, while the PCR method was used to determine the presence of resistant genes. Out of 159 commensal E. coli isolates, 39 (24.5%) were confirmed to have resistance. According to the MIC values, 37 (97.3%) and 1 (2.7%) isolate were phenotypically categorized as ESBL and ESBL/AmpC, respectively. All isolates showed resistance to ampicillin, while 97.4%, 56.4%, and 36% showed resistance to cefotaxime, ciprofloxacine, and azitromycine, respectively. Not all isolates that showed phenotypic resistance were found to be carrying the corresponding gene. The most prevalent resistant genes were gyrA, tetA, sul2, and tetB, which were present in 61.5%, 64%, 54%, and 49% of the isolates, respectively. The results clearly indicate that, besides their resistance to multiple antimicrobials, the commensal E. coli isolates did not necessarily carry any genes conferring resistance to that particular antimicrobial.
Two Novel Mosquitocidal Peptides Isolated from the Venom of the Bahia Scarlet Tarantula (Lasiodora klugi)
Authors: Ahmed Jamila , Walker Andrew A. , Perdomo Hugo D. , Guo Shaodong , Nixon Samantha A. , Vetter Irina , Okoh Hilary I. , Shehu Dalhatu M. , Shuaibu Mohammed N. , Ndams Iliya S. , King Glenn F. , Herzig Volker 
Published: June 2023

Effective control of diseases transmitted by Aedes aegypti is primarily achieved through vector control by chemical insecticides. However, the emergence of insecticide resistance in A. aegypti undermines current control efforts. Arachnid venoms are rich in toxins with activity against dipteran insects and we therefore employed a panel of 41 spider and 9 scorpion venoms to screen for mosquitocidal toxins. Using an assay-guided fractionation approach, we isolated two peptides from the venom of the tarantula Lasiodora klugi with activity against adult A. aegypti. The isolated peptides were named U-TRTX-Lk1a and U-TRTX-Lk2a and comprised 41 and 49 residues with monoisotopic masses of 4687.02 Da and 5718.88 Da, respectively. U-TRTX-Lk1a exhibited an LD50 of 38.3 pmol/g when injected into A. aegypti and its modeled structure conformed to the inhibitor cystine knot motif. U-TRTX-Lk2a has an LD50 of 45.4 pmol/g against adult A. aegypti and its predicted structure conforms to the disulfide-directed β-hairpin motif. These spider-venom peptides represent potential leads for the development of novel control agents for A. aegypti.
Upaya Pencegahan Hipertensi Pada Masa Pandemi Covid-19
Authors: Andriani Rizki 
Published: June 2023

Hipertensi menjadi salah satu penyakit tidak menular yang banyak dialami oleh masyarakat di Indonesia, termasuk di Aceh Barat. Masyarakat Desa Alue Tampak Kecamatan Kaway XVI menyebutkan jarang dilakukan penyuluhan kesehatan terkait hipertensi oleh pihak puskesmas terlebih saat pandemi yang menyebabkan beberapa pelayanan puskesmas tutup dan tidak adanya kader desa menyebabkan informasi terkait kesehatan minim sekali didapatkan oleh masyarakat. Tujuan kegiatan ini adalah meningkatkan pengetahuan, sikap dan perilaku masyarakat terkait pencegahan hipertensi pada masa pandemi covid-19. Kegiatan pengabdian masyarakat ini dilaksanakan di Desa Alue Tampak yang merupakan salah satu desa yang terletak di Kecamatan Kaway XVI Kabupaten Aceh Barat. Pengabdian menggunakan metode ceramah dan disertai pemeriksaan tekanan darah. Disarankan pihak terkait termasuk puskesmas memaksimalkan kegiatan edukasi hipertensi serta membina kader desa sebagai salah satu promotor kesehatan kepada masyarakat yang efektif pada masa pandemi sekalipun. Sehingga informasi terkait kesehatan khususnya edukasi hipertensi secara berkala dapat ditemukan dengan mudah oleh masyarakat dan diharapakan menurunkan angka terjadinya hipertensi
Edukasi jamu dan ramuan herbal dan untuk mencegah COVID-19 pada kader penggerak PKK Kota Batu
Authors: Sulistyowati Erna , Purnomo Yudi , Latuconsina Husain , Ramadhan Majida , Widiyana Anita Puspa , Hidayatullah Muhammad Fahmi , AS Nour Athiroh 
Published: June 2023

Pandemi Coronavirus disease atau yang biasa disebut COVID-19 menimbulkan dampak di berbagai sektor kehidupan masyarakat. Perlu upaya serius untuk meningkatkan ketahanan tubuh dengan memanfaatkan ramuan herbal yang banyak kita jumpai di kebun tanaman obat keluarga. Program edukasi kader penggerak PKK tentang ramuan herbal pencegahan COVID-19 ini dilaksanakan di Kota Batu propinsi Jawa Timur. Penyampaian program melalui ceramah, pelatihan dan FGD UMKM Griya Jamu Siti Ara Kota Batu pada Desember 2021. Edukasi interaktif dengan memberikan materi berupa ceramah tentang khasiat jamu/herbal dan pelatihan keterampilan meracik jamu/herbal. Analisis uji korelasi Kendall’s tau-b menunjukkan adanya hubungan karakteristik sosioekonomi dan pendidikan dengan persepsi COVID-19. Uji korelasi Pearson menunjukkan tidak terdapat hubungan paparan COVID-19 dengan persepsi peserta engan COVID-19. Danlagi, uji Chi-Square menunjukkan tidak terdapat hubungan karakteristik sosioekonomi dan pendidikan peserta dengan perilaku konsumsi jamu atau herbal. Sejumlah 35 peserta terlibat aktif selama kegiatan. Domisili mereka meliputi seluruh wilayah Kota Batu, Malang Jawa Timur. Dapat disimpulkan bahwa program edukasi ramuan herbal pada penggerak kader PKK mampu meningkatkan pengetahuan dan pemahaman masyarakat dalam pemanfaatan jamu/herbal untuk mencegah COVID-19 kepada seluruh lapisan masyarakat.
Literasi Keuangan Digital Peer-To-Peer (P2P) Lending Kepada Pelaku UMKM Di Sendangmulyo Semarang
Authors: Lestari Rohmini Indah , Arifin Zaenal , Sudarmanto Kukuh 
Published: June 2023

People started looking for information about Fintech Peer-To-Peer (P2P). Online loans have become attached a negative stigma; on the other hand, online credit platforms are very much needed by the community. Through the Financial Services Authority, the government uses this momentum to carry out digital financial literacy regarding online credit. In line with the government's goals, the purpose of Community Service activities from the Master of Law Study Program Universitas Semarang (USM) is to increase understanding, insight, and financial knowledge about Fintech P2P Lending to MSME Groups in Sendangmulyo Village, Semarang City. The material provided includes the development of Fintech P2P Lending in Indonesia. Second, explain the benefits and risks and how to choose an online loan platform registered and licensed at the OJK. Third, explain the consequences and legal protection for ordinary people so they do not worry when facing legal problems with illegal online credit companies. Fourth is the existence of an Investment Alert Task Force (SWI), which was formed to prevent and handle alleged unlawful acts by illegal online loan companies. This activity hopes that the community and MSME actors can choose a legal online credit platform and avoid the entanglement of illegal online credit. Masyarakat mulai mencari informasi mengenai Fintech Peer-To-Peer (P2P) Lending atau pinjaman online menjadi dikenal masyarakat setelah muncul berita maraknya jeratan pinjaman online ilegal. Pinjaman online menjadi lekat dengan stigma negatif, di sisi lain platform pinjaman online sangat dibutuhkan oleh masyarakat. Selaras dengan tujuan pemerintah maka tujuan dari kegiatan Pengabdian Kepada Masyarakat (PKM) adalah meningkatkan pemahaman, wawasan, pengetahuan keuangan digital mengenai Fintech P2P Lending kepada Kelompok UMKM di Kelurahan Sendangmulyo Kota Semarang. Materi yang diberikan meliputi perkembangan Fintech P2P Lending di Indonesia. Kedua, menjelaskan manfaat serta risiko serta bagaimana memilih platform pinjaman online yang terdaftar dan berijin di OJK. Ketiga, memberi penjelasan konsekuensi dan perlindungan hukum bagi masyarakat awam agar tidak khawatir saat menghadapi masalah hukum dengan perusahaan pinjaman online ilegal. Keempat, keberadaan Satuan Tugas Waspada Investasi (SWI) yang dibentuk pemerintah dalam rangka pencegahan dan penanganan dugaan tindakan melawan hukum oleh perusahaan pinjaman online ilegal. Harapan dari kegiatan ini adalah agar masyarakat dan pelaku UMKM dapat memilih platform pinjaman online yang legal serta terhindar dari jeratan pinjaman online ilegal.
UPAYA PENINGKATAN MUTU PEMBELAJARAN PENGAJARAN AGAMA ISLAM (DESKRIPTIF ANALITIK)
Authors: Musgar Musgar , Burhan Burhan , Roslina Roslina 
Published: June 2023

Upaya pengajar dalam meningkatkan belajar siswa dirasakan sangatlah besar pengaruhnya terhadap tingkah laku anak didik. Untuk dapat mengubah tingkah laku anak didik sesuai dengan yang diharapkan maka perlu seorang pengajar yang professional yaitu pengajar yang mampu menggunakan seluruh komponen pengajaran sehingga proses belajar mengajar tersebut berjalan dengan sesuai yang diharapkan. Hasil penelitian ini menggambarkan proses upaya pengajar pendidikan agama Islam dalam meningkatkan prestasi belajar siswa mata pelajaran pendidikan agama Islam melalui kegiatan ekstra kurikuler, pembahasan soal-soal, peningkatan kualitas pengajar agama Islam, metode pembelajaran. Setiap kegiatani dalam upaya meningkatkan prestasi belajar senantiasa dipengaruhi oleh faktor pendukung dan penghambat baik dari sisi dalam maupun penghambat dari sisi luar. Demikian halnya, pada upaya peningkatan prestasi belajar siswa.
POTENSI TUMBUHAN LOKAL SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Andarias S. Hafidhawati , D Yanti , Ardyati Dyah Pramesthi Isyana 
Published: June 2023

Sumber daya hayati yang melimpah di Indonesia sangat potensial untuk dimanfaatkan, salah satunya sebagai sumber belajar biologi. Pemanfaatan sumber daya di lingkungan sekitar sebagai sumber belajar dapat membantu siswa menghilangkan kejenuhan dan memberikan suasana belajar yang bervariasi. Tujuan penelitian ini adalah untuk mengkaji potensi tumbuhan yang ada di sekitar pemukiman penduduk di Desa Lasalimu Selatan untuk dimanfaatkan sebagai sumber belajar biologi. Penelitian ini adalah penelitian deskriptif kualitatif yang terdiri dari 2 tahap. Tahap I terdiri dari survei awal dan inventarisasi tumbuhan melalui wawancara, eksplorasi, dan pengamatan; dan tahap II adalah analisis potensi pemanfaatan tumbuhan lokal sebagai sumber belajar biologi. Hasil penelitian menunjukkan bahwa enam jenis tumbuhan lokal berpotensi untuk digunakan sebagai sumber belajar baik pada jenjang SMP maupun SMA pada materi klasifikasi dan pemanfaatan makhluk hidup, berbagai sistem dalam kehidupan tumbuhan, dan keanekaragaman hayati.
Coronary sinus as an anatomical landmark for atrial transseptal puncture
Authors: Votyakov L.  P. , Didenko M. V. , Menkov I. A. , Pasenov G. S. , Khubulava G. G. 
Published: June 2023

Aim. The study of interatrial septum (IAS) and coronary sinus (CS) syntopia in patients with atrial fibrillation (AF), who subsequently underwent pulmonary vein isolation with a cryoballoon and the determination of anatomical landmarks for puncture of the IAS.Methods. The data of preoperative computed tomography of the heart of 25 consecutive patients with AF, who subsequently underwent pulmonary vein isolation with a cryoballoon, were analyzed. Angulations describing IAS orientation and CS direction were measured. The relationships between IAS orientation, CS direction and size of left atrium were subsequently analyzed.Results. The mean angulations for IAS orientation and CS direction were 47.2±7.8° (range 27.6 - 57.3) and 47.2±7.8° (range 26.7 - 59.3) respectively. On the conventional clock face (direction of the flag of the puncture needle), these values corresponded to the following time: 4 h 34 min±15 min (from 3 h 55 min to 4 h 55 min) for the IAS orientation and 4 h 31 min±16 min (from 3 h 53 min to 4 h 54 min) for the CS direction. Statistically significant correlation was revealed between the IAS orientation and the CS direction (r = 0.77; p <0.001). Linear regression analysis by the least squares method showed that the CS direction explains 60% of the observed variability in IAS orientation. The final regression equation for the relationship between the IAS orientation and the CS direction is presented as: IAS orientation = 12.76 + 0.75 × CS direction. Analysis of the relationship between the IAS orientation and the size of the left atrium did not reveal any significant correlation and dependence (p=0.84). All 25 patients who took part in the study underwent pulmonary vein isolation with a cryoballoon. Puncture of the IAS from the first time was successful in 100% of patients. In 24 patients (96%), it was possible to achieve grade 4 occlusion of the pulmonary veins, and a bidirectional block was confirmed when checking the electrical activity of PV. All cryoballoon ablation procedures were completed without complications.Conclusion. In patients with AF, the CS direction can be a reliable predictor of the IAS orientation, which can be used in clinical practice. However, to verify the data and determine technical recommendations for transseptal puncture, additional clinical studies are needed.
Long-term outcomes of thoracoscopic ablation for atrial fibrillation
Authors: Strebkova E. D. , Revishvili A. Sh. , Malishenko E. S. , Artyukhina E. A. , Popov V. A. , Novikov M. A. , Yalova E. V. , Bondurko K. E. , Karmazanovsky G. G. , Kadirova M. 
Published: June 2023

The aim of this work is to analyze the effectiveness of thoracoscopic ablation (TSA) of atrial fibrillation (AF) and to define the risk factors for the return of atrial tachyarrhythmias after TSA in the long-term follow-up period.Methods. From January 2019 to December 2021, 150 patients with symptomatic atrial fibrillation (persistent 29.3% monitoring at the control points of the study, the results of which evaluated the effectiveness of the procedure.Results. The overall efficiency of TSA in the long-term follow-up period was 72.5%. After off-antiarrhythmic drugs, freedom from any atrial tachyarrhythmias was 79.2%, 70.5% and 68.9% after 6, 12 and 24 months, respectively. Additional catheter ablations after 3 months increase the effectiveness of the procedure to 82.9%. Important risk factors for the return of arrhythmia after TSA should be considered the patient’s age, duration of AF, previous catheter ablations and the left atria diameter of more 40 mm.Conclusion. The hybrid approach significantly improves the effectiveness of TSA for patients with non-paroxysmal forms of AF. The results obtained require further study of this problem in order to improve the quality of TSA and determine the optimal set of ablation lines, considering the risk factors for the return of arrhythmia.
RGB-D Visual Odometry via Low Order Gaussian Gradient Metrics
Authors: Yao Zhigang , An Xu , Charrier Christophe , Rosenberger Christophe 
Published: June 2023

<p>This paper gives a direct Visual Odometry (VO) of RGB-D cameras by using features conducted with low-order Gaussian derivative functions such as Gaussian gradient operator. By using the feature metrics locally, it improves further possibilities for sampling more reliable points from scenarios that are lack of structure or texture and is beneficial to continuous tracking. The proposed approach reaches relatively acceptable performance with a globally heuristic framework built on the general coarse-to-fine and inverse compositional estimation. Experimental results are conducted on a group of TUM datasets for validating the proposed approach.</p>
NDVI prediction of Mediterranean permanent grassland using soil moisture products
Authors: Milazzo Filippo , Brocca Luca , Vanwalleghem Tom , Peñuela Andres 
Published: June 2023

<p> Vegetation indexes are widely used as a proxy of vegetation status, they are often used to monitor and assess qualitatively and quantitatively the growing season. The Normalized Vegetation Index (NDVI) is the most widely used in agriculture, frequently as a proxy for different physiological and agronomical aspects, such as drought stress and crop yield losses evaluation. NDVI forecast is usually correlated to precipitation however, in Mediterranean and arid climates, it is not well correlated due to prolonged dry periods and sparse precipitation events. In this study, we forecast Mediterranean permanent grassland NDVI at 7 and 30 days ahead using machine learning and two soil moisture products as predictors, simulated soil moisture values and satellite-based Soil Water Index (SWI) values. Results show that both products can be used as reliable predictors of permanent grassland in Mediterranean areas. Predictions at 7 days are more accurate and better forecast the negative effect of drought on vegetation dynamics than 30 days. This study shows the potential of using a simple methodology and readily available data to predict the grassland growth dynamic in the Mediterranean area .</p>
ALGORITMA K-MEANS CLUSTERING ANALISIS RASIO AKTIVITAS MENGGUNAKAN PYTHON
Authors: Wisna Nelsi , Rani Melati Cahaya , Kastaman Kastaman 
Published: June 2023

Hasil kinerja keuangan perusahaan selama periode waktu tertentu dirinci dalam laporan keuangan. Evaluasi terhadap laporan keuangan diperlukan karena banyak penyebab yang dapat menyebabkan kenaikan dan penurunan data dalam laporan keuangan. Temuan evaluasi ini dapat memberikan informasi kepada para pengambil keputusan bisnis. Proses penilaian keberhasilan suatu perusahaan terlihat pada rasio-rasio keuangan perusahaan, termasuk rasio aktivitas. Total Asset Turnover (TATO), Inventory Turnover (ITO), dan Fixed Asset Turnover adalah rasio aktivitas yang dipertimbangkan dalam penelitian ini (FATO). Teknik kuantitatif dengan analisis K-Means Clustering yang digunakan sebagai metode dalam penelitian ini. Informasi yang digunakan adalah data sekunder dengan menggunakan 13 perusahaan subkontraktor yang terdaftar di Bursa Efek Indonesia sebagai unit observasi. Dari analisis yang telah dilakukan menunjukkan bahwa jumlah cluster yang optimal adalah 3 cluster. Hasil dari analisa tabel statistik deskriptifÂ bahwa perusahaan yang diteliti memiliki nilai rasio aktivitas rata-rata yang lebih besar pada tahun 2019 daripada yang perusahaan miliki pada tahun 2020. Hal ini menunjukkan bahwa penjualan perusahaan turun selama pandemi Covid-19.