bluuebunny/crossref_metadata_2025_split huggingface dataset:
Семіздіктің ерлердің эректильді және фертильді денсаулығына әсеріне, оны ота арқылы шешу жолдарына: әдебиетке шолу
Authors: Конакбаев Е.Ж. , Жанбырбекулы У. , Аннаоразов Ы.А. 
Published: January 2025

Аннотация
Өзектілігі: Дүние жүзінде өте қарқынды дамып келе жатқан семіздік ерлердің ұрық сапасының төмендеуінің ықтимал себептері болуы мүмкін. Ол гипоталамус -гипофиз-гоналдық осьіне әсер етеді және тестостерон мен В ингибиннің төмендете отырып, эстроген және май ұлпаларынан бөлінетін лептин сияқты гормондардың мөлшерін арттырады.Семіздік ума температурасының жоғарылауына, эректильді дисфункцияға және сперматозоидтардың ДНҚ үзілістеріне әкелуі мүмкін және көмекші репродуктивті әдістердің (КРӘ) нәтижелеріне теріс әсер етеді. Семіздікке шалдыққан ер адамдарға интервенциялық операциялардан кейін эректильді және репродуктивтік функцияларының жақсарауына әсерін сенімділікпен талдау әлі де зерттеулерді талап етеді.
Жүктілік кезіндегі әйелдердің өмір сүру сапасын талдау: әдебиетке шолу
Authors: Доланова Г.О. , Сарсенбаева Г.Ж. , Ахметова Л.В. , Саркулова И.С. 
Published: January 2025

Кіріспе: Жүкті әйелдердің денсаулығын жақсарту, ана мен перинаталдық сырқаттанушылық пен өлім-жітімді төмендету, Қазақстан Республикасының басым бағыты болып табылады.
Зерттеудің мақсаты – жүктілік кезіндегі әйелдердің өмір сүру сапасына әдеби шолу жасау.
Материалдар мен әдістер: Әдебиеттерге шолу; Elsevier, PubMed, Web of Science, Google Scholar, eLibrary деректеріне, сондай-ақ отандық басылымдарда ұсынылған зерттеу нәтижелеріне, шетелдік ғылыми жарияланымдарының талдаудын қамтиды.
Нәтижелер: әрі қарай, осы бөлімде жүктілік кезіндегі әйелдердің өмір сүру сапасын зерттеу туралы деректерге адеби шолу жасалынды. Әдебиеттерді шолу негізінде жүкті әйелдердің денсаулығы мен өмір салты туралы өзін-өзі бағалау анықталды. Бір неше зерттеу жұмыстарында өмір сүру сапасының жақсаруы ананың орташа жасы, алғашқы босану, ерте жүктілік жасы, экономикалық проблемалардың болмауы, білімнің жоғары деңгейі, жұмыс, неке, отбасының болуымен тығыз байланысты болды.
Қорытындылар: Өмір сүру сапасын бағалау жүктілік кезінде алдын алу шараларын уақытылы жүргізу тұрғысынан маңызды және жүкті әйелдердің денсаулығына назар аудара отырып, жүкті әйелдерге күтім жасау сапасының жоғарылауына және олардың әл-ауқатының жақсаруына әкелуі керек.
Comparison of antegrade and retrograde laparoscopic bilateral inguinal lymphadenectomy for penile cancer
Authors: Sun Dingqi , Zhang Hui , Diao Tongxiang , Zhang Keqin , Wang Jinhua 
Published: January 2025

ABSTRACT

Purpose:
To investigate and compare the feasibility, safety, and clinical outcomes of antegrade and retrograde laparoscopic bilateral inguinal lymphadenectomy for penile cancer.

Methods:
We retrospectively analyzed the clinical data of 32 patients with penile cancer admitted between 2018 and 2022. Among them, 17 patients underwent antegrade laparoscopic inguinal lymphadenectomy (ALIL group) and 15 underwent retrograde laparoscopic inguinal lymphadenectomy (RLIL group). The key surgical procedures and techniques are described. Operative time, intraoperative blood loss, hospital stay, drainage duration, postoperative complications, and follow-up data in both groups were statistically analyzed.

Results:
Surgery in both groups was successfully completed without the need for intraoperative conversion to open surgery. The operative time was significantly shorter for ALIL than for RLIL (P < 0.001). Significantly less intraoperative blood loss was reported with ALIL than with RLIL (P < 0.001). The ALIL group had a significantly shorter hospital stay than the RLIL group (P = 0.027). The number of removed lymph nodes in the ALIL group differed insignificantly from that in the RLIL group (P = 0.360). Postoperative drainage duration, recurrence, short-term survival, and postoperative complications were similar between both groups.

Conclusion:
In the patients with penile cancer, ALIL and RLIL yielded similar perioperative outcomes. However, ALIL was associated with shorter operative time, less blood loss, and shorter hospital stays. ALIL did not require repositioning of the laparoscopic instruments, thereby simplifying the procedure and minimizing patient trauma. Additionally, if needed, pelvic lymphadenectomy could be performed simultaneously from the same trocar position used in ALIL.
Factors retarding enhanced recovery from thermal ablation of liver tumors: A single-center prospective study
Authors: Zhang Lanxia , Dai Fei , Zeng Qingjing , He Xuqi , Guo Na , Chen Xiaorui , Li Kai 
Published: January 2025

ABSTRACT

Purpose:
To evaluate the risk factors that may delay enhanced recovery in the ablation of liver tumors.

Methods:
A total of 310 patients who underwent ultrasound-guided ablation of liver tumors under general anesthesia were prospectively enrolled. Baseline data, intraoperative parameters, and postoperative events were evaluated. Postoperative pain was scored using the visual analog scale (VAS). Logistic regression analysis was conducted for univariate and multivariate analyses.

Results:
The study included 42 females (13.5%) and 268 males (86.5%). The mean age of the sample was 57 ± 11 years old. The average length of stay (LOS) was 4.3 ± 2.4 days. A total of 199 out of 310 patients (64.2%) experienced moderate to severe pain (VAS score > 3). Seventy out of 310 patients (22.6%) experienced other complications. In the multivariable analysis, the number of lesions [odds ratio (95% confidence interval): 3.23 (2.15–4.84); P < 0.001], maximum diameter of lesions [1.12 (1.07–1.17), P < 0.001], and smallest distance between the lesions and the liver capsule [0.91 (0.89–0.94), P < 0.001] were risk factors for postoperative pain (VAS > 3). A history of alcohol consumption [2.62 (1.33–5.19), P = 0.005] was a risk factor for other complications. Surgical history [0.40 (0.24–0.67), P = 0.001] was a protective factor against LOS. Total operation time [1.01, 1.00–1.01, P = 0.009] was a mild risk factor for LOS.

Conclusion:
The number of lesions, maximum diameter of the lesions, smallest distance between the lesions and the liver capsule, total operation time, and a history of alcohol use were risk factors that may delay enhanced recovery in patients undergoing ablation of liver tumors. These findings may provide evidence to promote the use of the enhanced recovery after surgery protocol.
Comparison between lymph and non-lymph node resection in patients with stage IA non-small-cell lung cancer: A retrospective study
Authors: Lei Bao , Zhang Zhiping , Li Chunxia , Yang Jiao , Peng Jing , Zhao Yanqiu , Liu Guiming , Liang Han , Feng Jun , Xiang Xudong 
Published: January 2025

ABSTRACT

Objective:
This retrospective study aimed to determine the need for lymph node resection during surgical treatment in patients with stage IA non-small-cell lung cancer (NSCLC).

Materials and Methods:
A total of 1428 patients diagnosed with cT1N0M0 1 A stage NSCLC who underwent surgery were divided into two groups: lymphadenectomy (n = 1324) and nonlymphadenectomy (n = 104). The effects of lymph node resection on overall survival (OS) and recurrence-free survival (RFS) and on clinicopathological factors that affected the prognosis of the patients were investigated.

Results:
The group that underwent lymph node resection had a better 5-year OS (89.2% vs 81.1%) and 3-year RFS (87.6% vs 79.2%) than the one that did not. Multivariate Cox regression analysis revealed that the risk of OS in the nonlymphadenectomy group increased by 72% compared to that in the lymphadenectomy group [hazard ratio (HR), 1.72; 95% confidence interval (CI), 1.08–2.74; P < 0.05]. The risk of RFS in the group without lymphadenectomy increased by 45% compared to that in the group with lymphadenectomy (HR, 1.45; 95% CI, 0.98–2.14;P = 0.06). Significant reductions in the OS (HR, 5.90; 95% CI, 1.80–20.00; P < 0.005) and RFS (HR, 4.00; 95% CI, 1.50–11.00;P < 0.005) can be seen in the absence of lymph node resection in NSCLC patients with emphysema.

Conclusion:
A thorough evaluation and removal of the hilar and mediastinal lymph nodes may prove useful in determining the cancer stage and assessing the need for further treatment, thus enhancing the prognosis of patients with stage IA NSCLC.
Dihydroartemisinin ameliorates skeletal muscle atrophy in the lung cancer cachexia mouse model
Authors: Li Xin , Zhu Zhiying , Wen Keting , Ling Tingting , Huang Hong , Qi Li , Wang Bei 
Published: January 2025

ABSTRACT

Introduction:
Cancer cachexia (CC) is characterized by weight loss with specifically reduced skeletal muscles and adipose tissues in patients with late-stage cancer. Dihydroartemisinin (DHA), an effective antimalarial derivative of artemisinin, has been demonstrated to have anti-inflammatory and antitumor properties.

Materials and Methods:
This study examined the effects of DHA on the Lewis lung carcinoma (LLC)-induced CC mouse model.

Results:
DHA treatment significantly increases tumor-free body weight and food intake but decreases serum interleukin-6 level and tumor weight in CC mice. In addition, DHA treatment relieves muscle atrophy and decreases muscle ring finger 1 (MuRF1) and F-box-only protein 32 (Fbx32) expressions in CC mice. In vitro, DHA reverses the reduction in myotube formation induced by an LLC-conditioned medium and increases Fbx32 expression in C2C12 mouse myotubular cells.

Conclusions:
Our study demonstrated that DHA ameliorates the cachectic state and skeletal muscle atrophy in LLC-induced cachectic mouse models, suggesting its therapeutic potential for CC.
Effect of cryoablation on the spatial transcriptomic landscape of the immune microenvironment in non-small cell lung cancer
Authors: Zhou Jun , Wang Shengxi , Liu Ming , Li Zhaopei 
Published: January 2025

ABSTRACT

Background:
Cryoablation induces antitumor immune responses. Spatial transcriptomic landscape technology has been used to determine the micron-level panoramic transcriptomics of tissue slices in situ.

Methods:
The effects of cryoablation on the immune microenvironment in non-small cell lung cancer (NSCLC) were explored by comparing the Whole Transcriptome Atlas (WTA) panel of immune cells before and after cryoablation using the spatial transcriptomic landscape.

Results:
The bioinformatics analysis showed that cryoablation significantly affected the WTA of immune cells, particularly genes related to cellular components, biological processes, molecular functions, proliferation and migration, and cytokine-cytokine receptor interaction signaling pathways.

Conclusions:
The findings of this study suggest that cryoablation significantly impacts the biological functions of immune cells in the tumor microenvironment of NSCLC through multiple mechanisms.
The ability of contrast-enhanced ultrasound with Sonazoid to differentiate endometrial carcinoma from benign endometrial lesions: A preliminary, prospective, and multicenter clinical study
Authors: Li Xin , Huang Ying , Jiang Tianan , Luo Hong , Dong Xuejuan , Zhuo Tao , Cheng Wen , Zhang Xinling , Che Ying , Zhang Bingsong , Jiang Xue , Liu Rui , Zhang Jing , Liang Ping 
Published: January 2025

ABSTRACT

Objective:
To examine the diagnostic efficacy of contrast-enhanced ultrasound (CEUS) with Sonazoid (Sonazoid-CEUS) for endometrial lesions.

Methods:
In this prospective and multicenter study, data were collected from 84 patients with endometrial lesions from 11 hospitals in China. All the patients received a conventional US and Sonazoid-CEUS examination. The lesion characteristics based on US and Sonazoid-CEUS imaging were collected from the case report forms. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) were determined using histopathologic diagnosis as the gold standard.

Results:
Of the 79 patients included, 29 were diagnosed with benign lesions and 50 with endometrial carcinoma (EC). The accuracy, sensitivity, specificity, PPV, and NPV for Sonazoid-CEUS and US at differentiating EC from benign endometrial lesions were 82.2%, 94%, 62.1%, 81.0%, and 85.7%, and 79.7%, 96%, 51.7%, 92.3%, and 88.2%, respectively, with no significant differences observed for any of the values. For Sonazoid-CEUS, the best delineators of EC versus benign lesions were early enhancement and hyperenhancement (74% vs 53.3%, P = 0.029, 68% vs 45%, P < 0.001), and lesion size enlargement (76% vs 48%, P = 0.001). Despite finding no significant difference in the enhancement patterns (P = .367), a faster wash-in pattern with the contrast agent entering before the surrounding myometrium was more common in the EC vs benign cases (92% vs 48.3%).

Conclusions:
Sonazoid-CEUS has higher accuracy, specificity, and comparable sensitivity for differentiating EC from benign endometrial lesions compared with conventional US. It provides complementary hemodynamics information reflective of tissue vascularization, which may improve the overall diagnostic efficiency.
Integrin α6 and integrin β4 in exosomes promote lung metastasis of colorectal cancer
Authors: Cong Fengyun , Huang Jiahao , Wu Changtao , Zhong Huage , Qiu Guanhua , Luo Tao , Tang Weizhong 
Published: January 2025

ABSTRACT

Background:
Colorectal cancer (CRC) is one of the most common cancers worldwide. The mechanisms underlying metastasis, which contributes to poor outcomes, remain elusive.

Methods:
We used the Cancer Genome Atlas dataset to compare mRNA expression patterns of integrin α6 (ITGA6) and integrin β4 (ITGB4) in patients with CRC. We measured ITGA6 and ITGB4 expression levels in highly metastatic (i.e., HCT116 and SW620) and lowly metastatic (i.e., SW480 and Caco2) CRC cell lines. Exosomes were isolated from cell culture media and characterized using western blotting and nanoparticle analyses. The role of exosomes in lung metastasis was investigated using xenograft experiments in mice models, which received CRC cell injection and were treated with exosomes.

Results:

ITGA6 and ITGB4 were significantly overexpressed in CRC tissues, and ITGA6 was associated with the American Joint Committee on Cancer (AJCC) stage and outcome. ITGA6 and ITGB4, as well as exosomal ITGA6 and ITGB4, were significantly more highly expressed in HCT116 and SW620 cells than in SW480 and Caco2 cells. The proliferation and tubulogenesis of vascular endothelial cells were markedly decreased by disruption of ITGA6 and ITGB4 but were markedly increased by ectopic expression of ITGA6 and ITGB4. Exosomal ITGA6 and ITGB4 promoted CRC metastasis to the lung in vivo.

Conclusions:
Taken together, our findings suggested that exosomal ITGA6 and ITGB4 displayed organotropism to the lung and upregulated proliferation and tubulogenic capacities, which might help reduce lung metastasis from CRC. These findings provided new insights into the mechanisms of CRC metastasis and provided novel potential therapeutic targets.
Dermatofibrosarcoma protuberans: A clinical and pathological observational report of Asian samples from one center
Authors: Peng Qili , Lu Yi , Su Tingting , Tong Pengpeng , Huang Yixiong , Chen Rui 
Published: January 2025

ABSTRACT

Background:
Dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade fibrohistiocytic tumor with malignant potential. It is considered to have a high local recurrence rate due to the characteristic invasion of the finger-like lesion into the soft tissues.

Method:
This retrospective study presents details of 20 DFSP patients with a history of surgery and a long follow-up period. All patients were followed up for 10 years to assess the relationship between the surgical margin and the recurrence rate. Seventeen patients provided informed consent for detailed pathological examinations.

Results:
Twenty Asian patients with a mean age of 42.55 years were included in this study. The location of the DFSP varied among the individuals; seven were closed by sutures, four were full-thickness skin grafts, and nine were closed using a pedicled flap. The average follow-up period was 4.185 ± 3.09 years. Recurrence was observed in 8 out of the 20 patients 1–8 years after surgery (recurrence group). A significant (P = 0.04) difference in the average surgical margin was observed between the recurrence group (1.62 ± 0.74 cm) and the remaining patients (heal group; 2.83 ± 1.43 cm). The median Ki-67 value was 12%.

Conclusion:
Local control of DFSP after surgery is challenging. The first choice of DFSP treatment is surgery to clear the margins and reconstruct the area. Enhancing the diagnosis rate of DFSP during the initial visit is important for the proper management and operation opportunity.
Comparison of clinical outcomes in patients with advanced pulmonary sarcomatoid carcinoma treated with immunotherapy-based regimens or chemotherapy: A study based on the SEER database and multicentric real-world settings
Authors: Peng Duanyang , Xiong Le , Luo Yuxi , Chen Junxing , Zheng Yue’e , Zeng Xiaoli , Liu Shubin , Liu Anwen , Wang Xia , Zeng Zhimin 
Published: January 2025

ABSTRACT

Background:
Pulmonary sarcomatoid carcinoma (PSC) is a rare lung cancer characterized by early metastasis and invasion. It is predominantly diagnosed at a locally advanced or metastatic stage, hindering the possibility of surgical intervention. However, a standard treatment for advanced PSC remains unestablished. This study evaluated the effects of chemotherapy and immunotherapy-based strategies in patients with advanced PSC.

Methods:
The Surveillance, Epidemiology, and End Results (SEER) database and data from three cancer centers were used in this retrospective study. Progression-free survival (PFS) and overall survival (OS) were estimated using the Kaplan–Meier method. Univariate and multivariate analyses were conducted to identify the prognostic factors.

Results:
In total, 202 patients with stage IV PSC were identified from the SEER database (median OS, 5 months). The median follow-up time of patients from the three centers was 18.8 months. First-line treatment with immunotherapy-based regimens and chemotherapy was administered to 12 and 27 patients, respectively. The median PFS was 2.1 and 7.3 months [hazard ratio (HR), 0.16; 95% confidence interval (CI), 0.06–0.40; P < 0.001], while the median OS was 3.6 and 21.4 months (HR, 0.21; 95% CI, 0.09–0.50; P < 0.001) in the chemotherapy and immune-based groups, respectively. The immunotherapy-based regimen was an independent prognostic factor for PFS (HR, 0.21; 95% CI, 0.08–0.55; P = 0.001) and OS (HR, 0.20; 95% CI, 0.08–0.49; P < 0.001).

Conclusions:
Conventional chemotherapy offered limited benefits in patients with advanced PSC; however, those who received first-line immunotherapy-based regimens exhibited significantly improved responses.
Research progress on the structural and anti-colorectal malignant tumor properties of Shikonin
Authors: Chen Jinghua , Liu Jie , Nie Weiwei , Hou Xingqin , Zhang Xi , Liu Chao , Si Linxin , Zhang Mingzhu , Xu Shutao , Xie Qi , Liang Jing , Li Yan 
Published: January 2025

ABSTRACT
Colorectal cancer is the third most prevalent malignant tumor worldwide. Despite the advancements in surgical procedures and treatment options, CRC remains a considerable cause of cancer-related mortality. Shikonin is a naphthoquinone compound that exhibits multiple biological activities, including anti-inflammatory and anti-tumor effects as well as wound healing promotion. Recently, Shikonin has been increasingly used in basic research on colorectal malignant tumors. Therefore, we explored the mechanisms of action and structural improvements of Shikonin in colorectal cancer through a literature review to provide valuable insights for the advancement of research and development of related pharmaceuticals.
Interdisciplinary Approaches to Diagnostic Analysis in Behcet’s Disease
Authors: Sharma Arun Dev , Parihar Ajay , Tosh Sujata , Yadav Nidhi 
Published: January 2025

Abstract
The exploration of Behçet’s disease challenges the idea that “the oral cavity reflects systemic diseases.” This chronic systemic vasculitis, characterized by oral and genital ulcers, cutaneous lesions, and multi-organ involvement, poses diagnostic complexities. A 30-year-old male patient reported with Behçet’s syndrome, diagnosed via International Criteria for Behçet Disease 2014 and HLA B51 positivity, who achieved relief with Colchicine, highlighting the role of oral medicine.
Evaluation of Bcl-2, Mcl-1, and Bax as Potential Biomarkers in Chemo Radiotherapy Induced Oral Mucositis in Head and Neck Cancer Patients: A Pilot Study
Authors: Deepika R , Dharman Sreedevi , Jayaraman Selvaraj 
Published: January 2025

Abstract

Background:
Oral mucositis (OM) is an acute debilitating side effects of chemoradiotherapy (CRT) in head and neck cancer (HNC) patients. Salivary biomarkers are noninvasive and aid in early diagnosis and disease prevention.

Objective:
This study analyzed Bcl-2, Mcl-1, and Bax as potential biomarkers in CRT-induced OM in HNC patients.

Methods:
Forty-six HNC patients receiving CRT with OM were evaluated using WHO grading. Two time points were observed for saliva sample collection: Day 0 (prior to CRT) and Day 30 (CRT with OM) and from 46 healthy volunteers. Using an enzyme-linked immunosorbent assay (ELISA), levels of Bcl-2, Mcl-1, and Bax were measured. Oral mucositis progression was analyzed using Friedman’s test, and statistical significance between means of different salivary marker was determined using the ANOVA test.

Results:
From Day 0 to Day 30, grades of OM were statistically significant (P < 0.05). Apoptotic biomarkers showed statistically significant higher expression of proapoptotic regulator Bax and lower expressions of antiapoptotic markers Bcl-2 and Mcl-1 on Day 30 (severe OM) compared to Day 0 and healthy controls (P < 0.0001).

Conclusion:
Our research showcased Bax, Bcl-2, and Mcl-1 as early predictive indicators of OM, and targeted drugs should be developed against these to prevent onset and severity of oral mucositis that improves patients quality of life.
Fractal Analysis as an Aid in Gender Determination. A Retrospective Pilot Study
Authors: Srinivas Naveen , Ramdurg Praveen K. , Sali Ketki , Fazil K Mohammed , Rudrakshi Anusha B , Gachinmath Vijayalakshmi 
Published: January 2025

Abstract

Background of the Study:
Studies conducted for the determination of gender utilizing changes in trabecular pattern in mandible on an orthopantomogram have been very sparse. Hence, this study is designed to help in gender determination using an innovative aid, fractal analysis.

Aim:
The aim is to determine/establish the gender using fractal analysis.

Methodology:
A total of 1,248 orthopantomogram were screened during the period of 2020 and 2021 in the Oral and Maxillofacial Radiology Department of P. M. Nadagouda Memorial Dental College and Hospital of which 30 males and 30 females were selected between the age group of 20–30 years. The region of interest at the angle of the mandible on the right side was selected as the geometric center. The region of interest was again subjected to fractal analysis using ImageJ software, and the values were recorded by analyzing the trabecular pattern.

Result:
The data were analyzed statistically and it was noted that the mean fractal analysis values in females were 0.103 and 0.148 in males, which were significantly less when compared to the males.

Conclusion:
The results showed that fractal analysis can be used as an aid to assess the trabecular pattern in the determination of the sex of an individual.