bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailored Colloidal Shapes in Precursor Solutions for Efficient Blade‐Coated Perovskite Solar Modules
Authors: Yang Yongrui , Wu Jingjing , Zhang Kun , Wang Yang , Gao Jie , Guo Mengmeng , Min Fanyi , Wang Yumeng , Guo Lutong , Chen Yu , Qiao Yali , Song Yanlin 
Published: January 2025

AbstractMetal halide perovskite solar cells (PSCs) have emerged as one of the most promising candidates for next‐generation photovoltaic technologies. However, perovskite films deposited by blade‐coating usually exhibit inferior film morphology compared to those fabricated by spin‐coating, which hinders the power conversion efficiency (PCE) and stability of the scalable perovskite solar modules (PSMs). Herein, ellipsoidal colloids are tailored in the perovskite precursor solution by incorporating perovskite colloids and polymer additives. Compared to unregulated spherical colloids, the ellipsoidal colloids demonstrate more oriented packing during the blade‐coating process, which is due to the anisotropic driven force from the fluidic flow in the meniscus. As a result of the improved film morphology, the regulated PSCs and PSMs achieve superior PCE of 24.31% and 21.67% (21.37% certified), respectively, for aperture areas of 0.09 and 13.94 cm2, and 89% initial PCE after 600 h continuous operation.
γ‐Terpinene: Biorenewable Reductant for the Molybdenum‐Catalyzed Reduction of Sulfoxides, N‐Oxides and Nitroarenes
Authors: Hernández‐Ruiz Raquel , Solas Marta , Suárez‐Pantiga Samuel , Pedrosa María R. , Sanz Roberto 
Published: January 2025

AbstractA molybdenum‐catalyzed deoxygenation of sulfoxides, pyridine and quinoline N‐oxides, N‐hydroxybenzotriazoles, as well as the reduction of nitroarenes to anilines, has been developed using monocyclic terpenes such as γ‐terpinene as an environmentally benign hydrogen surrogate. The only byproducts generated are water and p‐cymene, under neat reaction conditions in which the terpene acts as both solvent and reducing agent. These features make this approach a highly attractive and sustainable alternative for the reduction of S‐O and N‐O containing compounds. Additionally, the reaction exhibited excellent chemoselectivity, tolerating a wide variety of functional groups.
Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis
Authors: Shin Dongkwan , Gong Jeong‐Ryeol , Jeong Seoyoon D. , Cho Youngwon , Kim Hwang‐Phill , Kim Tae‐You , Cho Kwang‐Hyun 
Published: January 2025

AbstractA cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT, is presented with which can reconstruct the core molecular regulatory network model and a reversion switch based on single‐cell transcriptome data over the transition process is identified. The usefulness of REVERT is demonstrated by applying it to single‐cell transcriptome of patient‐derived matched organoids of colon cancer and normal colon. REVERT is a generic framework that can be applied to investigate various cell fate transition phenomena.
Confining Surface Oxygen Redox in Double Perovskites for Enhanced Oxygen Evolution Reaction Activity and Stability
Authors: Hales Natasha , Huang Jinzhen , Sjølin Benjamin Heckscher , Garcia‐Padilla Alvaro , Borca Camelia Nicoleta , Huthwelker Thomas , Castelli Ivano E. , Skoupy Radim , Clark Adam H. , Andrzejewski Michal , Casati Nicola , Schmidt Thomas J. , Fabbri Emiliana 
Published: January 2025

AbstractNickel‐based double perovskites AA′BB′O6 are an underexplored class of oxygen evolution reaction (OER) catalysts, in which B‐site substitution is used to tune electronic and structural properties. BaSrNiWO6, with a B‐site comprised of alternating Ni and W, exhibits high oxygen evolution activity, attributed to the evolution of a highly OER active surface phase. The redox transformation of Ni2+(3d8) to Ni3+(3d7) combined with partial W dissolution into the electrolyte from the linear Ni(3d)‐O(2p)‐W(5d) chains drives an in situ reconstruction of the surface to an amorphized, NiO‐like layer, promoting oxygen redox in the OER mechanism. However, the high valence W6+(5d0) acts as a stabilizing electronic influence in the bulk, preventing the mobilization of lattice oxygen which is bound in highly covalent W─O bonds. It is proposed that the surface generated during the OER can support a lattice oxygen evolution mechanism (LOEM) in which oxygen vacancies are created and preferentially refilled by electrolytic OH−, while bulk O species remain stable. This surface LOEM (sLOEM) allows BaSrNiWO6 to retain structural integrity during OER catalysis. With a Tafel slope of 45 mV dec−1 in 0.1 m KOH, BaSrNiWO6 illustrates the potential of Ni‐based double perovskites to offer both OER efficiency and bulk stability in alkaline electrolysis.
South Korean study to prevent cognitive impairment and protect brain health through multidomain interventions via face‐to‐face and video communication platforms in mild cognitive impairment (SUPERBRAIN‐MEET): A randomized controlled trial
Authors: Moon So Young , Park Yoo Kyoung , Jeong Jee Hyang , Hong Chang Hyung , Jung Jiwoo , Na Hae Ri , Cho Soo Hyun , Kim Hyun Sook , Song Hong‐Sun , Choi Muncheong , Ku Bon D. , Moon Yeon Sil , Han Hyun Jeong , Hong Yun Jeong , Kim Eun‐Joo , Kim Geon Ha , Kim Ko Woon , Jang Hyemin , Yoon Soo Jin , Kim Hee‐Jin , Choi Seong Hye 
Published: January 2025

AbstractINTRODUCTIONWe investigated the efficacy of a multidomain intervention (MI) via face‐to‐face and video communication platforms using a tablet personal computer application in patients with mild cognitive impairment (MCI).METHODSThree hundred participants with MCI and ≥ 1 modifiable dementia risk factor, aged 60‐85 years, were randomly assigned to either the MI group, who underwent a 24‐week intervention, or the control group, who received usual care.RESULTSThe overall adherence rate to MI was 84.7%. The adjusted mean change from baseline at 24 weeks in the total scale index score of the repeatable battery for the assessment of neuropsychological status was 8.43 in the MI group and 4.26 in the control group (difference, 4.17; 95% confidence interval, 1.92‐6.43; p < 0.001). MI showed significant beneficial effects on cognition in both apolipoprotein E (APOE) ε4 carriers and noncarriers.DISCUSSIONMI can exert beneficial effects on the cognition of patients with MCI.Trial Registration: ClinicalTrials.gov identifier: NCT05023057Highlights
Although the controls also demonstrated improved performance in cognition, multidomain interventions showed significantly greater benefits for cognition in MCI compared to the controls in a randomized controlled trial.
Multidomain interventions improved depression and quality of life.
Multidomain interventions significantly positively impacted cognition in both APOE ε4 carriers and noncarriers.
Multidomain interventions may be more effective for amnestic than nonamnestic MCI.
Light‐Driven Stepwise Reduction of Aliphatic Carboxylic Esters to Aldehydes and Alcohols
Authors: Wei Delian , Bu Jiawei , Zhang Shengfu , Chen Shiyu , Yue Ling , Li Xipan , Liang Kangjiang , Xia Chengfeng 
Published: January 2025

AbstractThe reduction of carboxylic esters to aldehydes and alcohols is a fundamental functional group transformation in chemistry. However, the inertness of carbonyl group and the instability of ketyl radical anion intermediate impede the reduction of carboxylic esters via photochemical strategy. Herein, we described the reduction of aliphatic carboxylic esters with synergistic dual photocatalysis via phenolate‐catalyzed single electron transfer process and thiol‐catalyzed hydrogen atom transfer process. The competitive back electron transfer process was effectively inhibited by protonation of the ketyl‐type radical anion. This protocol enabled the efficient reduction of carboxylic esters to alcohols under mild conditions. By interruption of the reduction with prolinol, the step‐controlled reduction of carboxylic esters to aldehydes was accomplished. The developed process was also successfully applied to the preparation of deuterated alcohols and aldehydes from esters with D2O as the deuterium source.
Tandem Catalysis for Plastic Depolymerization: In Situ Hydrogen Generation via Methanol Aqueous Phase Reforming for Sustainable Polyethylene Hydrogenolysis
Authors: Lee Junsung , Kwon Taeeun , Hyuk Kang Ki , Won Wangyun , Ro Insoo 
Published: January 2025

AbstractDepolymerizing plastic waste through hydrogen‐based processes, such as hydrogenolysis and hydrocracking, presents a promising solution for converting plastics into liquid fuels. However, conventional hydrogen production methods rely heavily on fossil fuels, exacerbating global warming. This study introduces a novel approach to plastic waste hydrogenolysis that utilizes in situ hydrogen generated via the aqueous phase reforming (APR) of methanol, a biomass‐derived chemical offering a more sustainable alternative. Our results show that a bimetallic Ru−Pt/TiO2 catalyst achieved high conversion (85.1 %) and selectivity (81.0 %) towards liquid fuels and lubricant oils in a tandem process combining polyethylene (PE) hydrogenolysis and methanol APR. By tuning the metal loading, we identified that Pt enhances hydrogen production through methanol APR, while Ru drives C−C bond cleavage, which is crucial for PE hydrogenolysis. Isotope labeling analysis confirmed that hydrogen generated from methanol APR is effectively utilized in the PE hydrogenolysis reaction. This method was also successfully applied to post‐consumer polyolefin waste, with selectivity toward valuable products ranging from 75.0 % to 88.9 %. This study highlights an innovative strategy to reduce reliance on fossil‐fuel‐derived hydrogen in plastic waste depolymerization, promoting both sustainability and environmental protection.
Transient Allosteric Regulation of Catalysis by Effector Switching in a Pt2L4 Cage
Authors: Ashbridge Zoe , Reek Joost N. H. 
Published: January 2025

AbstractThe complexity of allosteric enzymatic regulation continues to inspire synthetic chemists seeking to emulate interconnected biological systems. In this work, a Pt2L4 cage capable of catalyzing the cyclization reaction of an alkynoic tosyl amide is orthogonally coupled to a diacid‐catalyzed carbodiimide‐hydration cycle. This new Pt‐catalyzed cyclization reaction is demonstrated to exhibit electronic regulation by inclusion of different guest effectors. The orthogonal diacid‐catalyzed carbodiimide hydration cycle produces transiently diverse guests that influence the rate of the Pt‐catalyzed cyclization reaction to different extents. Further complexity can be introduced to the system through displacing the transiently‐formed, weakly bound anhydride guest with the stronger binding fumaronitrile, affecting the catalytic rate to a larger extent for the duration of the orthogonal reaction cycle. The modulation of a Pt‐catalyzed cyclization reaction can thus be regulated transiently over the course of the reaction— either up‐ or down‐regulating the turnover frequency (TOF)—via coupling with a temporally controllable orthogonal process. This study demonstrates that principles of allosteric enzymatic regulation can also be applied to simple artificial systems.
Monomer Design Enables Mechanistic Mapping of Anionic Ring‐Opening Polymerization of Aromatic Thionolactones
Authors: Zheng Shaoqiu , Chen Shu‐Sen , Li Yang‐Yang , Liao Minjian , Liang Xuhui , Li Ke , Li Xiaopeng , Hu Jinming , Chen Dian‐Feng 
Published: January 2025

AbstractDegradable chalcogenide polyesters, e.g., polythioesters (PTEs), typically exhibit improved thermal, mechanical, and optical properties. Anionic ring‐opening polymerization (ROP) of thionolactones, an intrinsically promising yet underexplored approach to accessing PTEs, however, is still limited by: intolerance of metal catalysts, inadequate control over chain growth, and the absence of aromatic system. Monomer design‐boosted mechanistic studies may address the above challenges. Here, we present a new and highly reactive thionolactone synthesized from 1,1′‐binaphthyl‐2,2′‐diol (BINOL). Our investigations into polymerization kinetics and thermodynamics have underscored the importance of rapid initiation, eventually leading to the discovery of tetrabutylammonium 2‐naphthyl‐thiocarboxylate as a distinctive initiator that enables genuinely controlled and living polymerization of thionolactones. Ultimately, the atropisomerism inherent in BINOL has resulted in the creation of axially chiral PTE materials with tailored molecular weights, enantiomeric compositions, and topologies.
Degradation of Bisphenol A and Pyrocatechol in the Photocatalytic System in the Presence of Fe3O4@SiO2@PAEDTC‐Doped MIL‐101 (Fe) Under Visible and UV and Sunlight Irradiation
Authors: Al‐Musawi Tariq J. , Mengelizadeh Nezamaddin , Rahimpoor Razzagh , Balarak Davoud 
Published: January 2025

ABSTRACTIn this investigation, a novel core‐shell photocatalyst, denoted as Fe3O4@SiO2/PAEDTC (FSP)‐doped MIL‐101 (Fe) (FSPM), was synthesized through the sol–gel method and applied for the degradation of bisphenol A (BPA) and pyrocatechol (PCT) in aqueous solutions. Various analytical techniques were employed to assess the characteristics of the core‐shell photocatalyst. The resultant nanocomposite displayed specific attributes, including a saturation magnetization of 12 emu/g, a pore size of 1.35 nm, and a surface area of 992 m2/g, allowing for facile separation using a magnetic field. The optimal conditions for achieving highest BPA (%94.2) and PCT (%100) degradation efficiencies were found to be a pH of 7, 50 mg/L pollutant, a nanocomposite quantity of 0.8 g/L, and a radiation intensity of 8 W after 1 h. The BOD5/COD (biological oxygen demand during 5 days/chemical oxygen demand) ratio exceeded 0.4, accompanied by total organic carbon (TOC) and COD removal rates surpassing 85%. The tests conducted on scavenging suggested the formation of •OH, hole, and electron in the studied system. Among these, •OH was found to be the foremost species responsible for degrading BPA and PCT. Stability tests revealed that the photocatalyst could be recycled with a minimal reduction of only 7% during five reaction steps. The energy consumed by the system during different reactions ranged from 10.2 to 27.1 kWh/m3 for BPA degradation and from 10.9 to 29.4 kWh/m3 for PCT degradation at time of 10 to 60 min. Finally, the results of this study showed that the use of all three sources of radiation in the photocatalytic process can effectively destroy pollutants.
Elucidation on the Interaction Between Transferrin and Tetrachlorobisphenol A Based on Multispectroscopic Analysis, Molecular Docking Technique, and Conformational Studies
Authors: Feng Yuchuan , Zhang Qiumei , Li Xiting , Zeng Yujing , Wang Yiming , Zhang Lanfang , Tian Miaomiao , Chi Baozhu , Guo Hui 
Published: January 2025

ABSTRACTTetrachlorobisphenol A (TCBPA) is a kind of fire retardant extensively used in our life, but it can accumulate in organisms and potentially have toxic effects. Transferrin (TF) is a glycoprotein predominantly present in the blood plasma, serving as an essential mediator for the transportation of iron and other small molecules. In our study, various techniques including multi‐spectroscopic and molecular docking were employed to examine the interaction between TCBPA and TF. The TF–TCBPA complex was formed with the binding constant (Ka) in 2.181 ± 0.035 × 104 M−1 at 298 K. ΔH and ΔS were all negative, which means dominant driving forces were van der Waals forces and H‐bonds. The secondary structure of TF was changed by TCBPA, resulting in a decline in the α‐helix structure, and a corresponding increase in the β‐sheet structure. The molecular docking revealed that TCBPA was positioned within a pocket of TF, and it engaged in interactions with some amino acid residues through different forces. Importantly, the interaction between Tyr426/Asp392/His585 and TCBPA implies that TCBPA potentially interferes with the transportation of iron ions in vivo. All of above results indicated the adverse effects of TCBPA on the TF structure and activity should be more attention.
Avelumab + axitinib treatment in older patients with advanced renal cell carcinoma in Japan: Subgroup analyses of post‐marketing surveillance data by age
Authors: Oya Mototsugu , Ito Taito , Sato Masashi , Morita Makiko , Kajita Masahiro , Nonomura Norio 
Published: January 2025

AbstractIntroductionAvelumab + axitinib was approved in Japan in December 2019 for the treatment of curatively unresectable or metastatic renal cell carcinoma (RCC) based on results from the JAVELIN Renal 101 trial.Materials and MethodsTo evaluate the safety and effectiveness of avelumab + axitinib in older patients in general clinical practice in Japan, an ad hoc analysis of data from post‐marketing surveillance (PMS) by age group was conducted.ResultsThe analysis population included 328 patients who had received ≥1 dose of avelumab and were enrolled between December 2019 and May 2021. In total, 100 patients (30.5%) were aged ≤64 years, 130 (39.6%) were aged 65–74 years, and 98 (29.9%) were aged ≥75 years. Within these age groups, adverse drug reactions (ADRs) of safety specifications of any grade occurred in 46 (46.0%), 71 (54.6%), and 56 (57.1%), and of grade ≥3 in 13 (13.0%), 23 (17.7%), and 20 (20.4%), respectively. The most common ADRs of safety specifications across all age groups were thyroid dysfunction, infusion reactions, and hepatic function disorders. Median overall survival (OS) was not reached in any age group; 12‐month OS rates in patients aged ≤64, 65–74, or ≥75 years were 83.8%, 86.2%, and 80.0%, and objective response rates were 31.0%, 43.8%, and 30.6%, respectively.DiscussionAnalyses of PMS data show the safety and effectiveness of avelumab + axitinib across all age groups of patients with RCC in general clinical practice in Japan. The favorable benefit–risk profile was generally consistent with that observed in previous clinical trials.
Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis
Authors: Takahashi Mio , Nakamura Kohei , Chiyoda Tatsuyuki , Okada Chihiro , Nohara Sachio , Takamatsu Reika , Yanazume Shintaro , Kobayashi Hiroaki , Nishihara Hiroshi , Yamagami Wataru 
Published: January 2025

ABSTRACTBackgroundBorderline ovarian tumors (BOTs) differ from ovarian carcinomas in their clinical presentation and behavior, yet their molecular characteristics remain poorly understood. This study aims to address this gap by integrating whole‐exome sequencing (WES) and RNA sequencing (RNA‐seq) to compare BOTs with high‐grade serous carcinoma (HGSC), endometrioid carcinoma (EC), and clear‐cell carcinoma (CCC).ObjectiveTo elucidate the molecular features of BOTs and evaluate their similarities and differences in comparison to HGSC, EC, and CCC.MethodsThe study analyzed 44 ovarian tumor samples, employing WES to identify genomic alterations and RNA‐seq to examine transcriptomic profiles. Comparative analyses were conducted to investigate the molecular relationships among the tumor types.ResultsThe genomic analysis revealed that BOTs share significant similarities with EC. Furthermore, the transcriptomic data highlighted a novel and substantial similarity between BOTs and EC, suggesting deeper biological linkages, including potentially shared oncogenic pathways or tumor microenvironmental factors. These findings challenge traditional classifications and suggest a closer molecular alignment of BOTs with EC than previously understood.ConclusionsThis study provides new insights into the molecular characteristics of BOTs, demonstrating their significant resemblance to EC at both the genomic and transcriptomic levels. These results underscore the potential need to reconsider the molecular classification of ovarian tumors and open new avenues for research into the pathogenesis and treatment strategies for BOTs.
Predicting Outcomes in Esophageal Squamous Cell Carcinoma Using scRNA‐Seq and Bulk RNA‐Seq: A Model Development and Validation Study
Authors: Zhang Jiaqi , Song Shunzhe , Li Yuqing , Gong Aixia 
Published: January 2025

ABSTRACTBackgroundAltered glucose metabolism is a critical characteristic from the beginning stage of esophageal squamous cell carcinoma (ESCC), and the phenomenon is presented as a pink‐color sign under endoscopy after iodine staining. Therefore, calculating the metabolic score based on the glucose metabolic gene sets may bring some novel insights, enabling the prediction of prognosis and the identification of treatment choices for ESCC.MethodsA total of 8, 99, and 140 individuals from The Gene Expression Omnibus database, The Cancer Genome Atlas database, and the Memorial Sloan Kettering Cancer Center, respectively, were encompassed in the investigation. Patients diagnosed with ESCC after surgery were enrolled for further validation.ResultsA total of 13 kinds of cell clusters were screened, and the squamous epithelium was identified with the highest score. And 558 differential genes were selected from the single‐cell RNA sequencing (scRNA‐seq) dataset. Four glucose metabolism‐related genes, namely, SERP1, CTSC, RAP2B, and SSR4, were identified as hub genes to develop a risk prognostic model. The model was validated in another external cohort. According to the risk score (RS) determined by the model, the patients were categorized into low‐ and high‐risk groups (LRG and HRG). Compared with LRG, HRG indicated poor survival and decreased drug sensitivity. Additionally, the immune microenvironment and pathway enrichment were different between the two groups. Immunohistochemical staining revealed that hub genes were expressed differently in ESCC tissues, high‐ and low‐grade intraepithelial neoplasia, and adjacent normal tissues.ConclusionFour hub genes (SERP1, CTSC, RAP2B, and SSR4) screened based on glucose metabolism developed a predictive model in ESCC patients. The RS was established as an independent risk factor for predicting prognosis. These findings may enhance understanding of ESCC's molecular profile and serve as a new prognostic tool for better patient stratification and treatment planning in clinical practice.
Exploring Cervical Adenocarcinoma: Epidemiological Insights, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms
Authors: Li Shuhui , Liu Congrong , Weng Liang 
Published: January 2025

ABSTRACTBackgroundCervical cancer poses a significant threat to women's health and encompasses various histological types, including squamous cell carcinoma (SCC), cervical adenocarcinoma (CA), and adenosquamous carcinoma. CA, in particular, presents a formidable challenge in clinical management due to its low early detection rate, pronounced aggressiveness, high recurrence rate, and mortality, compounded by the complexities associated with late‐stage treatment. There is limited understanding of the similarities and differences in the pathogenesis mechanisms between CA and SCC, such as tumor heterogeneity and the tumor immune microenvironment (TME).MethodsA literature search was carried out in the PubMed, Web of Science, and Google Scholar databases using the following research terms: “gynecological oncology,” “cervical cancer,” “cervical adenocarcinoma,” “epidemiology,” “diagnosis and treatment of cervical adenocarcinoma,” “Human papillomavirus,” “World Health Organization,” “tumor microenvironment,” “single‐cell RNA sequencing,” “molecular mechanism,” and “preclinical research model.”ConclusionThis review consolidates the epidemiological characteristics, diagnostic and therapeutic hurdles, and the latest advances in research on CA. It aims to highlight the significant heterogeneity of the TME characteristics exhibited by CA compared to SCC. Additionally, we also summarize the common preclinical models for CA and discuss the advantages and disadvantages of using various models in research. We aspire that the discussions presented herein will offer novel insights and directions for subsequent research, as well as clinical diagnosis and treatment strategies for CA.