bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Vitamin D-enriched Bone Graft in Surgically-induced Critical-sized Bone Defects: An experimental study
Authors: Markopoulos Georgios , Agrogiannis George , Perrea Despoina N. , Iliopoulos Dimitrios C. , Nikolaou Vasileios S. 
Published: June 2023

Background:
Restoration of bone defects in the craniac vault may require the use of autografts, allografts, xenografts, or synthetic grafts. There are promising data that vitamin D may play a positive role in graft incorporation. The purpose of the present study is the evaluation of the impact of vitamin D addition to human-derived bone grafts in the healing of critical-sized bone defects in porcine skulls.

Materials and Methods:
Four identical critical-sized defects were created in the calvaria of 8 adult Landrace Large White pigs. The first defect was left blank as control, the second defect was filled with human-derived bone graft, the third defect was filled with human-derived bone graft enriched with a low concentration of vitamin D (2 mg/mL), and the fourth defect was filled with human-derived bone graft enriched with a high concentration of vitamin D (10 mg/mL). The animals were sacrificed after 12 weeks. Harvested tissue specimens were qualitatively evaluated by histology. New bone formation (bone volume/tissue volume) was quantitatively measured by histomorphometry.

Results:
Signs of bone formation were evident in all bone sockets. Mean values of the bone volume/tissue volume of the 4 defects were 10.91%, 11.05%, 10.40% and 10.87% respectively, at 12 weeks. In 5 animals, high concentration of vitamin D caused a significant improvement in bone formation in relation to controls. In 3 animals, a high concentration of vitamin D was associated with decreased bone formation compared with controls. No statistical difference was observed in the graft healing among the 4 graft sites (P > 0.05).

Conclusions:
The results of this study have shown that the addition of vitamin D to human-derived bone grafts does not have a significant effect on bone formation and graft incorporation in critical-sized bone defects of the porcine calvaria. Further high-quality studies are needed to fully elucidate the role of vitamin D in bone formation and bone graft union.
Comparable Outcomes for Exclusive Lipofilling and Lipofilling-Implant Combination in Breast Reconstruction: A Retrospective Cohort Study
Authors: Razzouk Kais , Fitoussi Alfred , Tabrizi Arash Rafii 
Published: June 2023

ABSTRACTBackgroundAutologous fat grafting combined with prosthesis placement has become a widely accepted standard for breast reconstruction. However, a growing trend toward exclusive lipofilling-based reconstruction (LBR) is emerging. In this retrospective study, we compared the surgical and cosmetic outcomes of LBR to combined breast reconstruction (CBR) using fat grafting in conjunction with prosthetic placement.MethodsThis single-center retrospective cohort study included 170 patients who underwent mastectomy between 2014 and 2018 and received either LBR or CBR. The surgical parameters and outcomes were compared between the two groups.Additionally, the cosmetic outcome was evaluated using a Likert-type ordinal scale by the patients, surgeon, and nurse.ResultsThe study included a total of 170 patients, with 91 patients receiving LBR and 79 patients receiving CBR in combination with prosthetic placement. Patients who received exclusive lipofilling had more sessions on average than those who received prosthetic placement (3.7 lipofilling sessions vs. 2.17 sessions). Additionally, the volume of injected fat was significantly higher in the lipofilling group. No reconstruction failures were reported in either group. Patient, surgeon, and nurse satisfaction scores were high, with an average score of 4.7/5, 4.8/5, and 4.8/5, respectively, at 24 months of follow-up.ConclusionIn this follow-up study, we demonstrate that exclusive lipofilling results in satisfactory cosmetic outcomes with a low rate of complications. This minimally invasive approach to breast reconstruction can serve as a viable alternative to flap and prosthetic-based reconstruction.
Spatial non-equilibrium and distribution dynamic evolution of the development level of national health in China’s provinces
Authors: Xiao Qin , Xiao Haiting 
Published: June 2023

BackgroundPhysical health is the material basis of a country’s socio-economic development, and an in-depth study of the spatial pattern and dynamic evolution of the distribution of national physical fitness in China is of great practical significance for improving national physical fitness.MethodsBased on the national health physique monitoring data of 31 provinces (cities, districts) in China in 2005, 2010 and 2015, the Gini coefficient and its decomposition method and nonparametric density estimation method were used to study the population, males, females, urban and rural nationals in China. Spatial non-equilibrium characteristics and dynamic evolution trend of healthy physique development level.ResultsThe regional disparities in the development level of health and physique among the general, female, urban and rural nationals in China all show a trend of narrowing at first and then expanding.There is obvious heterogeneity in the regional disparities in the development level of national health and physique within the three regions of East, Middle and West. The distribution of the nuclear density curve of the development level of the Chinese national health constitution showed a dynamic characteristic of evolution from a “spiky, multi-peak” shape to a “broad-peak, single-peak” shape.ConclusionsThe low-level provinces have the characteristics of “club convergence”. However, there is a “catch-up effect” between provinces with low levels of rural national health and physique development.
Endometrial cyclin A2 deficiency is associated with human female infertility and is recapitulated in a conditional knockout mouse model
Authors: Aljubran Fatimah , Shumacher Katelyn , Graham Amanda , Gunewardena Sumedha , Marsh Courtney , Lydic Michael , Holoch Kristin , Nothnick Warren B. 
Published: June 2023

AbstractProper action of the female sex steroids, 17β-estradiol (E2) and progesterone (P4) on endometrium is essential for fertility. Beyond its role in regulating the cell cycle, cyclin A2 (CCNA2) also mediates E2 and P4 signalingin vitro, but a potential role in modulating steroid action for proper endometrial tissue development and function is unknown. To fill this gap in our knowledge, we examined human endometrial tissue from fertile and infertile women for CCNA2 expression and correlated this with pregnancy outcome. Functional assessment of CCNA2 was validatedin vivousing a conditional Ccna2 uterine deficient mouse model whilein vitrofunction was assessed using human cell culture models. We found that CCNA2 expression was significantly reduced in endometrial tissue, specifically the stromal cells, from women undergoing in vitro fertilization who failed to achieve pregnancy. Conditional deletion of Ccna2 from moue uterine tissue recapitulated the inability to achieve successful pregnancy which appears to be due to alterations in the process of decidualization, which was confirmed using in vitro models. From these studies, we conclude that CCNA2 expression during the proliferative/regenerative stage of the menstrual cycle acts as a safeguard allowing for proper steroid responsiveness, decidualization and pregnancy. When CCNA2 expression levels are insufficient there is impaired endometrial responsiveness, aberrant decidualization and loss of pregnancy.Graphical Abstract
Channeling Chirmi
Authors: Vyas Astha , Srivastava Ritu , Gupta Parul 
Published: June 2023

Learning outcomes
The case is intended to assist students to:1. understand the customer’s purchase decision with reference to channel values;2. evaluate and assess the channel strategy using conventional and digital channels; and3. design the channel strategy for start-ups in emerging markets.

Case overview/synopsis
The subject area for this teaching case was marketing management. The teaching case could be used for the undergraduation and graduation levels of students. The case was about the marketing channel strategy of a small start-up boutique called Chirmi in India, with the theory of consumption values explained. In this case, primary data was taken directly from Chirmi, whereas secondary data for market analysis was taken from various reports, articles and other sources. Because the owner provided the records and documentation, the account was therefore substantiated by the collected first-hand information. The case uses quantitative methods to make students understand the channel arithmetic and consumption values of all the channels used by Chirmi.

Complexity academic level
In the course of core marketing classes at the undergraduate and graduate levels, this case may be used. The case addresses the channel structure, including wholesaling, retailing and e-commerce. Distribution channel management, the theory of consumption values and e-commerce marketing management are explained. Evaluation of channel strategy, design, implementation and management is emphasized.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS: 8: Marketing.
Driving smartness for organizational performance through Industry 4.0: a systems perspective
Authors: Abiodun Temitayo Seyi , Rampersad Giselle , Brinkworth Russell 
Published: June 2023

PurposeThe internationalization of business has grown the production value chains and created performance challenges for industrial production. Industry 4.0, the digital transformation of industrial processes, promises to deliver performance improvements through smart functionalities. This study investigates how digital transformation translates to performance gain by adopting a systems perspective to drive smartness.Design/methodology/approachThis study uses qualitative research to collect data on the lived experiences of digital transformation practitioners for theory development. It uses semi-structured interviews with industry experts and applies the Gioia methodology for analysis.FindingsThe study determined that enterprise smartness is an organizational capability developed by digital transformation, it is a function of integration and the enabler of organizational performance gains in the Industry 4.0 context. The study determined that performance gains are experienced in productivity, sustainability, safety and customer experience, which represents performance metrics for Industry 4.0.Research limitations/implicationsThis study contributes a model that inserts smartness in the linkage between digital transformation and organizational outcomes to the digital transformation and production management literature.Practical implicationsThe study indicates that digital transformation programs should focus on developing smartness rather than technology implementations, which must be considered an enabling activity.Originality/valueExisting studies recognized the positive impact of technology on performance in industrial production. The study addresses a missing link in the Industry 4.0 value creation process. It adopts a systems perspective to establish the role of smartness in translating technology use to performance outcomes. Smart capabilities have been the critical missing link in the literature on harnessing digital transformation in organizations. The study advances theory development by contributing an Industry 4.0 value model that establishes a link between digital technologies, smartness and organizational performance.
Creeping COVID catastrophe: the impact of COVID-19 on nonprofits by sector
Authors: Intindola Melissa , Burke-Kolehmainen Cari 
Published: June 2023

PurposeThis study aims to provide a timely “first look” at the impact of COVID-19 lockdown restrictions on the financial distress of nonprofits.Design/methodology/approachThis study uses Internal Revenue Service Form 990 returns, US census information, and Oxford COVID-19 workplace restriction data and utilizes logistic regression to analyze results.FindingsNonprofits with greater COVID-19 lockdown restrictions are more likely to experience financial distress, whether measured by a 30% reduction in total, program, management and general, or fundraising expenses. This paper also examines results by subsector using National Taxonomy of Exempt Entities data and finds that the Human Services and Public and Society subsectors drive the full sample results when the authors use total, program, or managerial and general expenses in the measure of financial distress, and the Education and Environment and Animals subsectors drive the results when using fundraising expenses in the measure of financial distress.Originality/valueBroadly speaking, this paper contributes to the limited research stream examining the impact of crises on nonprofits. More specifically, this study is among the earliest to rely on quantitative data to investigate such effects.
Adjustment strategies for firms affected by international sanctions
Authors: Aliasghar Omid , Rose Elizabeth L. 
Published: June 2023

Purpose
When terrorism threaten geopolitical stability, many policymakers turn to economic sanctions. In this way, governments and multilateral organizations continue to affect corporate and managerial choices, through the shaping and constraining of international trade policies. Still, most of the international business remain relatively quiet about the impact of the non-market environment on firms’ strategic efforts. Questions remain about how firms adjust their strategies in the face of the often-sudden impact of changes in multilateral rules and enforcement mechanisms. This study aims to address this question by shedding light on three potential adjustment strategies for firms that have been impacted by sanctions.

Design/methodology/approach
As part of a larger, multimethod study, the authors undertook 16 semi-structured interviews with senior managers of firms whose operations have been affected by international sanctions.

Findings
International and political tensions can affect businesses in many ways, from exporting to strategies associated with global knowledge sourcing. Learnings from organizations that have had to respond to sudden and extreme changes in their fragile ecosystems will aid this study. In this commentary paper, the authors offer suggestions about how to adapt, respond and operate in a new reality.

Originality/value
While the imposition of long-term political sanctions, especially by powerful nations and multilateral institutions, has become more frequent, how businesses cope with these extreme external shifts still remains unknown. This paper focuses on firms operating in a sanctioned regime, investigating how they deal with these sudden changes in their environment.
Scaling social impact in women-led social enterprises in developing countries: a knowledge-based perspective
Authors: Hafiz Nusrat , Mohiuddin Md. Fazla , Abdul Latiff Ahmad Shaharudin , Yasin Ida Md. , Abd Wahab Sazali , Abdul Latiff Ahmed Razman 
Published: June 2023

PurposeAlthough scaling is considered a “hot topic”, very little is known about how knowledge management (KM) assists in scaling social impact. To fill this gap, the authors draw on knowledge-based and social capital theories and investigate how various KM practices and external networks (e.g. bridging social capital) affect scaling social impact in developing countries.Design/methodology/approachApplying structural equation modeling (SEM) with AMOS version 23, the authors conducted a survey with 354 women leaders who are working in women-led social enterprises in Dhaka, Bangladesh.FindingsThe authors found that knowledge codification, training and mentoring, and bridging social capital are positively and significantly associated with scaling social impact.Originality/valueThis is one of the pioneering study that explore how KM impacts scaling social impact for women-led social enterprises in the context of a developing country. The authors also extend knowledge-based theory by applying it at the individual level. Finally, the authors enhance the understanding of women entrepreneurship by showing that women entrepreneurs in developing countries are also utilizing bridging social capital to overcome challenges associated with scaling social impact.
Accounting and religious influence in the seventh day Adventist church in the Pacific islands
Authors: Kuma Clayton , Fukofuka Peni , Yong Sue 
Published: June 2023

Purpose
This paper aims to investigate the practice of accounting in the Seventh-day Adventist church of the Pacific Islands and pays particular attention to the coexisting of two control devices: accounting and religion.

Design/methodology/approach
This paper implemented a qualitative field study design collecting interview data from church members from the Solomon Islands, Tonga and Fiji. Data were also collected through focus group discussions, document reviews, website analysis and participant observations. Pierre Bourdieu’s thinking on symbolic violence, doxa and capital are used to interpret the findings.

Findings
This paper’s main contribution shows that while there is a divine and profane divide, social agents, given their agency, can move back and forth from one side of the divide to the other. Accounting as a control device does not include features such as faith, which is helpful for decision-making; accordingly, religion is relied upon when it comes to decision-making. In contrast, accounting has features that are useful for stewardship purposes. Accordingly, when it comes to the church’s stewardship function accounting in the form of financial reports is relied upon.

Research limitations/implications
Pacific Island culture almost permeates all facets of life, including church life; however, this study did not clarify this. Later studies can explore the implications of culture on the deployment of accounting in a religious setting.

Practical implications
This rich empirical study describes the control dynamics and the tension between accounting and religion in a religious organisation. Accounting needs to adapt to churches’ unique characteristics, whereby religious/doctrinal beliefs must be accounted for and respected. Unlike in the corporate world, accountants in churches cannot fully practice their training or exercise the kind of influence they usually hold in organisations due to their religious belief systems.

Originality/value
To the best of the authors’ knowledge, this research is one of a few studies on the religion-accounting relationship. While the focus of earlier studies was generally on a secular and sacred divide, this study looks at coexisting of accounting and religion. This study adds to the sparse literature on accounting and religion and their controlling influence.
Funding a “good death”: the financial crisis facing hospices
Authors: Scourfield Peter 
Published: June 2023

Purpose
This paper aims to highlight current finding issues relating to the provision of hospice care services which are largely provided by the independent sector and heavily reliant on charitable fund raising. The primary focus is on the UK, but it is an issue of relevance to many other countries around the world.

Design/methodology/approach
The paper is an opinion piece informed by contemporary reports, official publications and research findings, as well as the author’s own work within the hospice sector.

Findings
As with many other countries around the world, the bulk of hospice funding in the UK comes from charitable donations of various kinds. However, the impact of COVID-19 highlighted both the fragility of this funding model and the precarious nature of hospice sector finances currently.

Practical implications
This is an issue of growing importance that affects older people and their families not only in the UK but in all countries with ageing populations. Hospices play an important role in providing end-of-life care and, with demand for services steadily rising due to demographic trends, there are important questions about the sustainability of the current hospice funding model.

Social implications
Issues of funding require a much higher level of engagement from policymakers if hospice care is going to continue to play a significant part in achieving a good death for people from all sections of society.

Originality/value
Although hotly debated within the hospice sector and in official reports, this issue has yet to be properly examined within academic circles.
The significance of dense fine speckled pattern in antinuclear antibody‐associated rheumatic disease and coexisting autoantibodies: A propensity score‐matched cohort study
Authors: Cheng Chiao‐Feng , Lan Ting‐Yuan , Kao Jui‐Hung , Lu Cheng‐Hsun , Chang Yu‐Cheng , Huang Yi‐Min , Yang Feng‐Jung , Chen Jen‐Hao , Lin Yen‐Chun , Chuang Chieh‐An , Chang Chih‐Hui , Li Ko‐Jen , Shen Chieh‐Yu , Hsieh Song‐Chou 
Published: June 2023

AbstractAimTo investigate the relationship between the prevalence of antinuclear antibody (ANA) ‐associated rheumatic diseases (AARD) and the presence of dense fine speckled (DFS) and homogeneous patterns in ANA tests.MethodsThis retrospective study enrolled adult patients with either a DFS or homogeneous pattern in their ANA test. A mixed pattern was defined as the presence of more than one pattern reported in the test. The presence of anti‐DFS70 antibodies and other common autoantibodies were detected using EUROLINE ANA Profile 23. A 1:2 propensity score matching was applied to control for demographic and other interfering factors.ResultsA total of 59 patients with a DFS pattern were enrolled and compared with a matched homogeneous group. The DFS group had a significantly lower prevalence of AARD (3.4% vs. 16.9%, p = .008) and the subgroup with anti‐DFS70 antibodies showed an even lower prevalence (2% vs. 20%, p = .002). Among the 33 patients with monospecific anti‐DFS70 antibodies, five had a mixed pattern, and all patients with common autoantibodies had an isolated DFS pattern.ConclusionsThe findings of this study suggest that patients with a DFS pattern in their ANA test may have a lower prevalence of AARD compared with those with a homogeneous pattern. However, an isolated DFS pattern in ANA testing does not necessarily indicate the presence of monospecific anti‐DFS70 antibodies or AARD. Confirmatory testing for the monospecific anti‐DFS70 antibody is mandatory to exclude AARD.
Taking stock of systems for organizing existential and global catastrophic risks: Implications for policy
Authors: Taggart Gabel 
Published: June 2023

AbstractThis article takes stock of the literature that is advancing knowledge about how to classify, organize and think about existential risks and globally catastrophic risks altogether. It then points out policy implications from this literature and applies those implications to a short case study on the National Risk Register, a comprehensive risk policy in the United Kingdom. In doing so, it names three broad systems that have emerged in the literature, which are those that organize risks by (1) consequences of risks, (2) sources or causes of risks and (3) risk processes and interactions with human systems. Organizing risks by consequences aids in risk prioritization, while classifying risks by source or cause aids in risk prevention and mitigation. Analysing risk processes and interactions with human systems opens the policy frame to broader policies of risk response and resilience.