bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective mechanisms of polyphenols against NSAIDs-induced intestinal cell death in Caco-2 cells
Authors:   , Boonyong Cherdsak 
Published: September 2023

Indomethacin (INDO) and diclofenac (DIC) cause intestinal cell death through reactive oxygen species (ROS), endoplasmic reticulum stress (ER stress) and mitochondrial dysfunction. This study investigated the cytoprotective effects of certain natural polyphenolic antioxidants against INDO- and DIC-mediated Caco-2 cell death as well as underlying mechanisms. In this study, caffeic acid (CAF), curcumin (CUR), epigallocatechin gallate (EGCG), gallic acid (GAL), hypophyllanthin (HYPO), naringenin (NAR), phyllanthin (PHY), piperine (PIP), quercetin (QUE), rutin (RUT) and silymarin (SLY) were able to decrease ROS production in Caco-2 cells treated with INDO and DIC. However, only EGCG, QUE and RUT (100 µM) could prevent INDO- and DIC-mediated cytotoxicity after 72-h treatment. Their cytoprotective action could be related to suppression of CHOP expression, Bax/Bcl-2 ratios and loss of mitochondria membrane permeability (MMP). Further study on the cytoprotective effect of EGCG demonstrated that its underlying mechanism involved with suppressions of p-PERK/p-eIF-2α/ATF-4/CHOP and p-IRE-1α/p-JNK1/2 expressions. Another two polyphenols CAF and NAR (100 µM) protected Caco-2 toxicity from INDO treatment, but not DIC treatment. Moreover, the effect of NAR involved with suppression of Bax/Bcl-2 mRNA ratios and loss in MMP. Apparently, NAR did not affect CHOP expression. A group of polyphenols including CUR (50 µM), GAL (100 µM), HYPO (10 µM), PHY (10 µM), PIP (10 µM) and SLY (100 µM) had no effects on INDO-/DIC-induced Caco-2 cytotoxicity. Instead, CUR, NAR, PHY, PIP and SLY enhanced cytotoxicity caused by DIC exposure. Further study on the potentiation effect of PHY suggested that this compound suppressed survival p-Nrf-2/HO-1 expression in DIC-treated cells, leading to increased activation of PERK/CHOP pathway and apoptosis. Taken together, the cytoprotective capabilities of polyphenols against INDO-/DIC-induced Caco-2 apoptosis might be involved with suppressions of the specific ER stress signaling pathways, but not the direct ROS scavenging mechanism.
Effects of magnesium substitution on electronic properties of calcium difluoride
Authors:   , Chintananon Natthasart 
Published: September 2023

We use density functional theory to find the phase transitions of CaF2. The results show that CaF2 adopts the fluorite structure, with the space group Fm-3m, in the range 0f 0-8 GPa and transforms into the cotunnite structure, with the space group Pnma, above 8 GPa. The electronic band structure of the Pnma-CaF2 structure expresses an insulating phase, and the bandgap collapses under pressure above 70 GPa. In this work, we proposed a new decoration of Ca/Mg-substituted fluorides MgxCa1-xF2, using the cluster expansion technique which is commonly used to study alloys. We found that the Mg0.25Ca0.75F2, with a Pm structure, is stable at 70 GPa. Our electronic band structure calculations indicate that the substitution of Mg increases the bandgaps of the Mg0.25Ca0.75F2 compounds above 70 GPa.
Structural phase transitions and electronic properties of LI2o2 and Na2o2 under high pressure for Co2 capture application
Authors:   , Jimlim Pornmongkol 
Published: September 2023

Since pressure induces exotic chemical and physical properties of materials, investigation of the high-pressure effect on structural phase transition and the related properties is paramount. Structural phase transitions and electronic properties of Li2O2 and Na2O2 under high pressure were investigated using first-principles calculations based on the density functional theory. Structural phase transitions of Li2O2 up to 500 GPa were predicted at ~75 GPa from the P63/mmc to the P21 structures and at ~136 GPa from the P21 to the P21/c structures. The calculated band gaps of all phases increase with elevated pressure. At 11 and 40 GPa, the band gaps decrease, while the O-O bond lengths and the electron localization function (ELF) values increase, resulting in the O-O stretching mode softening. Structural phase transitions of Na2O2 up to 300 GPa were investigated with elevated temperature up to 600 K based on the quasi-harmonic approximation. Two new phases were predicted consisting of the Amm2 and the P21/c structures, which are stable at low temperatures in the 0-22 and 22-28 GPa pressure ranges, respectively. At the elevated temperature, the P-62m and the Pbam structures more favor temperature than the Amm2 and the P21/c structures, respectively. In the 2-3 and 9-10 GPa pressure ranges, some phonon modes softening and some elastic stiffnesses decreasing result in the phonon free energies decreasing and the ELF values increasing. Their band gaps also increase with increasing pressure. High-pressure Raman measurements and Raman calculations for Na2O2 provide the evidence for the presence of an unidentified structure at 8.6-21.5 GPa and the Pbam structure at 24.8 GPa. The calculated Gibbs free energy changes of the CO2 capture reactions by Li2O2 and Na2O2 suggest that the reactions are spontaneous under high pressure and temperature studied.
The roles and perceptions of the Thai Ministry of Foreign Affairs through governmental politics in the Preah Vihear Temple dispute
Authors:   , Duangratana Ornthicha 
Published: September 2023

In the Thai-Cambodian Preah Vihear Temple dispute, the perceptions of the Thai Ministry of Foreign Affairs (MFA) are investigated. Through the employment of role theory, the MFA's national role conceptions (NRCs), since the Cold War period and with concentration on the years from 2008 to 2013, are explicated. The research presents that the organizational characteristics of the ministry conduce the propensity for cooperative NRCs. At the same time, as the agency dealing with foreign affairs, the material and ideational elements in the external environment are important determinants. Nevertheless, at times, the national public opinion and the decline of the MFA's autonomy have proven to counteract the ministry's organizational standpoint in the task of diplomacy and pragmatism in the dealings of external affairs. Moreover, whether the MFA's NRCs are translated to actual policy outcomes, it depends on the interplay of actors in the Thai foreign-policy domain. In the period covered, different dynamics between the foreign-policymaking actors are apparent. With the governmental politics approach, the dissertation demonstrates that Thailand's foreign policies do not represent the NRCs held by the MFA when governmental politics is high in confrontation and the MFA possesses low influence in the action channel.
Effectiveness of the enhanced psychological well-being intervention in family caregivers of schizophrenic patients
Authors:   , Thongthammarat Yada 
Published: September 2023

Most of the family-based interventions focus on assisting patients more than the family caregivers. Family caregivers of schizophrenic patients require intervention which focuses more on their strengths than on solving problems for schizophrenic patients. For this study with 127 family caregivers of schizophrenic patients in Nonsung District, Nakornratchasima Province, Thailand, 63 were in the intervention group and 64 were in the control group. The 4-session intervention was held every other week. Psychological well-being and burden of care were assessed pre-intervention, post-intervention, and at 3-month follow-up. The intervention group had significant increase in psychological well-being after receiving the intervention, but did not have significant decrease in burden of care after receiving the intervention. Further research is needed to develop specific interventions to better alleviate burden of care for family caregivers, which might include skill-building and psychoeducation for schizophrenic patient care.
Prostate cancer screening in Thailand: cost-effectiveness analysis and budget impact evaluation
Authors:   , Romyen Chavalit 
Published: September 2023

Objectives: As public health insurance schemes in Thailand did not included prostate cancer screening in their benefits package, this study aimed to systematically gather the effectiveness and explore the cost effectiveness of difference prostate cancer screening programs for the Thai population and find the financial impact for adapting prostate cancer strategy.

Method: We perform systematic and network meta-analysis, health economic evaluation using Markov’s model to compare four prostate cancer screening strategies with no screening options. And we perform budget impact analysis to assess the potential burden for adopting selected strategy.

Result: The result from systematic review and network meta-analysis suggest the difference of outcome between each prostate cancer screening strategies, ESRPC Scheme yield the most efficacy in term of prostate cancer diagnosis rate (OR 1.65; 95%CI 1.60-1.71) and Goteborg scheme yield the most efficacy in term of prostate cancer related death(OR 0.41; CI 0.31-0.56). Based on the pharmacoeconomic result simulated by Markov’s model, ESRPC and Goteborg schemes compared to no screening strategy yield ICUR at 97,350 THB and 95,554 THB respectively while CAP Scheme and PLCO Schemes are dominated option. For applying prostate cancer screening strategy (ESRPC Scheme), total budget impact per patients estimated for 5 years were 302.58, 601.92, 901.45, 1200.95 and 1500.64 THB respectively

Conclusion: Comparing to No Screening option, ESRPC scheme and Goteborg scheme is Cost Effectiveness strategy options. (ICUR Within threshold of 1XGDP (Around 150,000-200,000 THB). Applying ESRPC screening scheme will affect budget impact in Thailand which needed to weight with clinical benefit as screening will improve life year gained and QALY.
Development of prediction model for chronic kidney disease in type 2 diabetics in Thailand
Authors:   , Tuntayothin Wilailuck 
Published: September 2023

Diabetes mellitus (DM) is a major contributing factor that leads to end stage renal disease (ESRD) with unsuitable clinical management. Chornic kidney disease (CKD) prediction model could prevent the progression of CKD to ESRD. However, current CKD prediction models in patients with type 2 DM were developed to predict ESRD. This study aimed to develop prediction model for CKD stage 3 in patients with type 2 DM in Thailand. This was a 10-year retrospective cohort study obtaining data of patients with type 2 DM from electronic database of Taksin hospital during 1 January 2008 to 31 December 2017. The outcome variable was the present of CKD stage 3 which was defined as estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2. The total patients of 2,178 were randomly assigned into training dataset for developing model (N=1,525) and validation dataset for model validation (N=653). The study used Cox proportional hazard regression for model development. For model performance, while model discrimination was conducted using Harrell’s C-statistic, model calibration was evaluated by Hosmer-Lemeshow chi-square test and survival probability curve. The results showed that the median follow-up time was 1.29 years (interquartile range, 0.5- 2.5 years) and 385 patients or 17.68% with CKD stage 3. Data analysis identified five CKD stage 3 predictors including age, female, urinary albumin to creatinine ratio, baseline eGFR, and Hemoglobin A1c. Based on these five CKD predictors, two CKD prediction models were developed, model 1 using laboratory testing data and model 2 using simplified or proxy data. Both models demonstrated good discrimination with C-statistic of 0.890 and 0.812, respectively, and accurate prediction. These two CKD prediction models are recommended for health providers to use as an input for decision making on clinical management which could prevent diabetic kidney disease and for raising patients’ awareness on health prevention.
The relationship between Chinese viewers' attitude toward fansub videos and attitude toward sponsorship
Authors:   , Lou Ruiqi 
Published: September 2023

This paper aimed to study Chinese viewers’ attitude toward watching fan-subtitled online courses, attitude toward sponsorship activity, and attitude toward sponsor brand. The relationships among three attitude variables were examined based on Fritz Heider’s balance theory. A quantitative approach was employed and an online questionnaire was distributed on the online forum of the most popular fansub group's website in mainland China. 216 samples were collected. The finding showed that three variables were favorable, and significantly positively correlated. This suggested that sponsoring fan-subtitled video could contribute to a positive attitude towards brands.
Generation z's attitude towards music consumption on Joox online music streaming application
Authors:   , Pibulpanuvat Ravisrarat 
Published: September 2023

The objective of this study is to investigate Thai generation Z’s attitude towards their music consumption on Joox online music streaming application. A qualitative approach was selected, using semi-structured, in-depth interviews. Ten participants, Thai generation Z music listeners, aged 17-24 years old who consume Joox online music streaming application every day for at least six months, were selected through purposive, snowballing sampling methods. The interviews were interpreted using In Vivo coding. This study based on the theoretical framework of Ajzen and Fishbein’s (2000) theory of planned behavior which suggested that actual behavior is motivated by the combination of attitude towards the behavior, subjective norms, and perceived behavioral control.

The result demonstrated that among all attitudinal kinds, a strong positive attitude towards music consumption and Joox application contributed to the unique and heavy music consumption of generation Z. Among all subjective norms that were identified, peers influence prominently motivated participants’ music selection and new music adoption. The convenience of online music streaming platforms and Joox application granted a strong perceived behavioral control among participants and made their gratified daily music consumption possible. This study also drew guidelines from uses and gratification theory and agenda setting theory. Additional notion of consumer involvement with music was found to be relevant to the interviewees’ consumption patterns.
Correlation of allergen specific immunoglobulin to house dust mites and commensal microbes in atopic dogs and identification of major allergen in dermatophagoides farinae
Authors:   , Khantavee Nathrada 
Published: September 2023

To confirm a causative allergen in atopic dogs could test through intradermal skin testing (IDT) or allergen-specific IgE serology testing (ASIS). ASIS is more practical, convenient and safer. However, the results of ASIS could be affected by source and type of allergen. Crude allergen extracts were still used in commercial testing and protein antigens of skin microbes were not included in the panel of testing. In this study, our group developed serology test for confirming house dust mite allergy called Dermatophagoides farinae and D. pteronyssinus, and measuring specific immunoglobulin to skin microbes on dogs like Malssezia pachydermatis yeast and Staphylococcus pseudintermedius bacteria. The results was found that high IgE levels to house dust mites could be used to differentiate atopic dog with allergy to house dust mites and atopic dogs without allergy to house dust mites. Moreover, IgG1 levels could also use to differentiate house dust mite allergy and non-house dust mite allergy by using lower sample volumes than IgE about 100 times. In the other hand, total IgG and IgG2 levels could not be used to differentiate house dust mite allergy and non-house dust mite allergy in atopic dogs. Both of IgE and IgG1 levels showed the same degrees of agreement to IDT. By investigation through two-dimensional IgE blotting, ten proteins of house dust mites that related to house dust mite allergy in atopic dogs were found, Der f 28 protein is interesting and should be selected to apply for a component-resolved diagnostics. Alpha-enolase, serine protease, and arginine kinase are the critical protein to be a cause of cross reaction. The results of specific immune response to skin microbes were found that atopic dogs had higher specific IgE levels to both skin microbes than healthy dogs. This indicated that skin microbes could act as allergen in atopic dogs. Other specific IgG1 and IgG2 to these skin microbes also high. However, none of any types specific immunoglobulin to skin microbes related to skin severity scores in atopic dogs determining through the Canine Atopic Dermatitis Lesion Index. We concluded that levels of specific immunoglobulin to skin microbes did not relate to skin severity.
Effect of fish antifreeze protein type iii supplementation to semen extender on cryopreserved dog spermatozoa
Authors:   , Bayusalaksa Rudal 
Published: September 2023

Ice binding protein such as antifreeze protein (AFP) type III have been used as a cryoprotectant and proven to improve sperm survival in some species but dog. Addition of Equex STM paste to semen freezing medium provides beneficial effects on cryopreserved dog sperm. Hence, the objectives of this study were to (a) evaluate the effects of AFP (Experiment I) and (b) its combination with Equex STM paste on cryopreserved dog spermatozoa (Experiment II). The semen samples were pooled to allow for a sufficient number of sperm and to reduce an individual variation. Only sperm-rich fractions with total motility more than 70% were used. Pooled semen from three dogs was split in equal portions according to the number of tested extenders in Experiment I or II. Two steps-dilution freezing methods with 4 different tris egg-yolk based extender were used in experiment I, e.g. P0; no AFP added (control), P1; 0.01 µg/mL, P2; 0.1 µg/mL, P3; 1 µg/mL (w/v) and experiment II, e.g. E1; 0.1µl/mL AFP), E2; 0.1µl/ml AFP plus 1% (v/v) Equex STM paste and E3; 1% (v/v) Equex STM paste. Sperm evaluation was done one week after the freezing. Thawing was performed by immerse freeze-straw into 37oC water for 60 second. Sperm motility and velocity were evaluated by Sperm Class Analyzer® (SCA Microptic SL, Barcelona, Spain). Post-thawed samples were stained for sperm viability (SBYR-PI fluorescent staining), acrosome integrity (FITC-PNA and PI) and mitochondrial membrane potential (JC-1), and were evaluated. Plasma membrane functional integrity (PMFI) was evaluated by hypo-osmotic swelling test (HOST). In Experiment I, overall, regardless of time post thawing, addition of AFP type III at a concentration of 1µg/ml (P3) significantly deteriorated total motility, progressive motility and sperm velocity compared to P0 (control), P1 and P2. Semen extenders supplemented with 0.01 or 0.1µg/ml AFP yielded no significantly better quality of frozen-thawed dog sperm than those of the control. Immediately post-thawing, there are no significant differences among 3 treatments and control groups (P>0.05) except for the progressive motility. The progressive motility was significantly lower in P3 (P>0.05). In general, all parameters decreased after 1h incubation at 37°C (P>0.05). However, post-thawed sperm velocity (VCL, VSL and VAP) did not significantly decline at 1h in P2. In Experiment II, overall, Equex-contained extenders (E2, E3) significantly improved sperm quality post-thawing compared to E1 (P<0.0001). A combination of AFP and Equex STM paste provided a beneficial effect on sperm viability immediately after thawing (P<0.05). In conclusion, supplementation of AFP type III at a concentration of 0.01µg/ml provided a beneficial effect on dog sperm velocity. Higher concentration of AFP (1µg/ml) deteriorated post-thawed sperm quality. Addition of 0.01 µg/ml into Equex-contained semen extenders was essential for maintaining sperm viability post-thawing.
อัตราส่วนผสมสูงสุดของน้ำมันไพโรไลซิสเพื่อให้ได้มาตรฐานน้ำมันดีเซลของไทย
Authors:   , แสงเนตร อรปวีณ์ 
Published: September 2023

ปัญหาการนำเข้าน้ำมันปริมาณมากทำให้ประเทศไทยตื่นตัวต่อการหาเชื้อเพลิงทดแทน ขณะเดียวกันขยะพลาสติกที่ไม่ย่อยสลายตามธรรมชาติเป็นอีกหนึ่งปัญหาหลักของประเทศ
และมีแนวโน้มจะเพิ่มความรุนแรงขึ้น การนำขยะพลาสติกมาเปลี่ยนเป็นน้ำมันไพโรไลซิส
เพื่อใช้ทดแทนการนำเข้าน้ำมันเชื้อเพลิงจึงเป็นอีกทางเลือกหนึ่ง ดังนั้น งานวิจัยนี้มีจุดมุ่งหมายเพื่อศึกษาอัตราส่วนน้ำมันไพโรไลซิสในน้ำมันดีเซลที่มีคุณภาพตามเกณฑ์มาตรฐาน
และความคุ้มค่าทางเศรษฐศาสตร์เบื้องต้นของการผสมน้ำมันไพโรไลซิสในน้ำมันดีเซลหมุนเร็ว โดยทำการทดสอบตัวอย่างน้ำมันไพโรไลซิสจาก 2 แหล่งที่มา ตามมาตรฐานการทดสอบ ASTM
จำนวน 6 รายการทดสอบ ได้แก่ ความถ่วงจำเพาะ ความหนืด จุดไหลเท กำมะถัน จุดวาบไฟ
และการกลั่น พบว่าน้ำมันไพโรไลซิสตัวอย่างที่ 1 (1PO) ที่ผลิตจากขยะพลาสติกสามารถ
ผสมที่อัตราส่วนมากกว่าร้อยละ 10 โดยปริมาตร ผ่านเกณฑ์มาตรฐานคุณภาพทุกรายการ
ส่วนน้ำมันไพโรไลซิสตัวอย่างที่ 2 (2PO) ที่ผลิตจากวัตถุดิบหลายชนิด เช่น ยาง ขยะพลาสติก และน้ำมันหล่อลื่นใช้แล้ว สามารถผสมที่อัตราส่วนน้อยกว่าร้อยละ 10 โดยปริมาตร
ไม่ผ่านเกณฑ์มาตรฐานคุณภาพ 1 รายการ และเมื่อนำเอาน้ำมันไพโรไลซิสตัวอย่างที่ 1
มาศึกษาต่อในเชิงปริมาณสูงสุดที่ผสมแทนน้ำมันดีเซลได้ พบว่าน้ำมันไพโรไลซิสตัวอย่างที่ 1 สามารถผสมได้สูงสุดที่อัตราส่วนน้ำมันไพโรไลซิสร้อยละ 18 โดยปริมาตร (1PO18)
และเมื่อวิเคราะห์ความคุ้มค่าทางเศรษฐศาสตร์เบื้องต้นที่สัดส่วนดังกล่าว โดยเปรียบเทียบกับราคา ณ โรงกลั่นของน้ำมันดีเซล พบว่าราคา ณ โรงกลั่นของน้ำมันดีเซลผสมน้ำมันไพโรไลซิสต่ำกว่าราคาน้ำมันดีเซลเฉลี่ยอยู่ที่ 0.19 บาทต่อลิตร ดังนั้น จึงมีความเป็นไปได้ในการผลักดันให้น้ำมันไพโรไลซิสเป็นเชื้อเพลิงจากพลังงานทดแทนในภาคขนส่งต่อไป
การพัฒนาชุดกิจกรรมการเรียนรู้ส่งเสริมทักษะการรู้ดิจิทัลที่ใช้เทคนิคระดมสมองด้วยการออกแบบอินโฟกราฟิกส์แบบมีปฏิสัมพันธ์สำหรับนักเรียนชั้นมัธยมศึกษา
Authors:   , ละออกุล กิตติ 
Published: September 2023

การวิจัยในครั้งนี้ มีวัตถุประสงค์เพื่อ 1) สร้างรูปแบบชุดกิจกรรมการเรียนรู้ส่งเสริมทักษะการรู้ดิจิทัลที่ใช้เทคนิคระดมสมองด้วยการออกแบบอินโฟกราฟิกส์แบบมีปฏิสัมพันธ์สำหรับนักเรียนชั้นมัธยมศึกษา และ 2) ศึกษาผลของการใช้ รูปแบบชุดกิจกรรมการเรียนรู้ส่งเสริมทักษะการรู้ดิจิทัลที่ใช้เทคนิคระดมสมองด้วยการออกแบบอินโฟกราฟิกส์แบบมีปฏิสัมพันธ์สำหรับนักเรียนชั้นมัธยมศึกษา กลุ่มตัวอย่างที่ใช้ในการพัฒนารูปแบบ คือ ผู้เชี่ยวชาญด้านการผลิตสื่อการเรียนการสอนและด้านการรู้ดิจิทัล กลุ่มตัวอย่างที่ใช้ใน การทดลอง คือ นักเรียนมัธยมศึกษาตอนปลาย จำนวน 43 คน เครื่องมือที่ใช้ในงานวิจัย ได้แก่ แบบสัมภาษณ์ผู้เชี่ยวชาญ แบบประเมินรูปแบบ ชุดกิจกรรม แผนการจัดการเรียนรู้ แบบวัดทักษะการรู้ดิจิทัล และแบบสอบถามความคิดเห็นในการเรียนโดยใช้รูปแบบฯ วิเคราะห์ข้อมูล ด้วยการใช้ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน และการทดสอบค่าที (t-test) ผลการวิจัยพบว่า รูปแบบชุดกิจกรรมการเรียนรู้ส่งเสริมทักษะการรู้ดิจิทัลที่ใช้เทคนิคระดมสมองด้วยการออกแบบอินโฟกราฟิกส์แบบมีปฏิสัมพันธ์สำหรับนักเรียนชั้นมัธยมศึกษาที่พัฒนาขึ้นประกอบด้วย 5 องค์ประกอบ ได้แก่ (1) สื่อการสอน (2) ผู้สอน (3) การระดมสมอง (4) อินโฟกราฟิกส์ และ (5) การวัดและประเมินผล มีขั้นตอน 5 ขั้นได้แก่ (1) กิจกรรมการเรียนการสอน และ กระตุ้นด้วยคำถาม (2) กิจกรรมระดมสมองภายในกลุ่ม เพื่อตอบคำถาม (3) กิจกรรมแชร์คำตอบ ค้นหาข้อสรุป (4) กิจกรรมระดมสมองเพื่อ สร้าง และ แชร์ ผลงาน และ (5) สรุปและประเมิน ผลการทดลองใช้รูปแบบการใช้ชุดกิจกรรมการเรียนรู้ส่งเสริมทักษะการรู้ดิจิทัลฯ พบว่า คะแนนเฉลี่ยทักษะการรู้ดิจิทัลหลังเรียนของกลุ่ม ตัวอย่างสูงกว่าคะแนนเฉลี่ยก่อนเรียนอย่างมีนัยสำคัญทางสถิติที่ระดับ .05