bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismicity-based 3D model of ruptured seismogenic faults in the North-South Seismic Belt, China
Authors: Rong Yilin , Bai Yongliang , Ren Mengjiao , Liang Mingjian , Wang Zhenjie 
Published: January 2023

The North–South Seismic Belt produces the most frequent strong earthquakes in the Chinese continental region, such as the MS 8.0 Wenchuan earthquake on 12 May 2008 and Ms 7.0 Lushan earthquake on 20 April 2013. This seismicity results in significant hazards. Fault geometry modeling is crucial for analyzing earthquake preparation and trigger mechanisms, simulating and predicting strong earthquakes, inverting fault slip rates,etc.In this study, a novel method for obtaining geometric models of ruptured seismogenic faults over a large area is designed based on datasets from surface fault traces, fault orientations, focal mechanism solutions, and earthquake relocations. This method involves three steps. 1) An initial model of the fault geometry is constructed from the focal mechanism solution data. This initial model is used to select the earthquake relocation data related to the target fault. 2) Next, a fine model of the fault geometry with a higher resolution than that of the initial model is fitted based on the selected earthquake relocation data. 3) The minimum curvature interpolation method (Briggs, 2012)is adopted to build a 3D model of the subsurface fault geometry according to the three-dimensional coordinates of nodes on all profiles of each fault/segment. Based on this method and data collected in the North–South Seismic Belt, the fine morphologies of different faults along 1,573 transverse profiles were fitted, and a 3D model of 263 ruptured seismogenic faults or fault segments in the North–South Seismic Belt was built using the minimum curvature spatial interpolation method. Since the earthquake number decreases with increasing depth, the model uncertainty increases with increasing depth. Different ruptured faults have different degrees of seismicity, so different fault models may have different uncertainties. The overall fitting error of the model is 0.98 km with respect to the interpreted results, from six geophysical exploration profiles.
Late Guadalupian–early Lopingian marine geochemical records from the Upper Yangtze, South China: Implications for climate-biocrisis events
Authors: Li Ruixuan , Sun Shi , Xia Wenpeng , Chen Anqing , Ogg James G. , Yang Shuai , Xu Shenglin , Liao Zhiwei , Yang Di , Hou Mingcai 
Published: January 2023

Major paleoenvironmental changes occurred during the Guadalupian-Lopingian boundary (GLB) transition, but the causative linkages among the Emeishan Large Igneous Province (LIP), end-Guadalupian crisis and climatic fluctuations are still in dispute. Variation of geochemical proxies preserved in the sedimentary records is important evidence in examining potential links between volcanisms and environmental changes. Herein, we carried out a comprehensive study of carbon/strontium isotope and trace element geochemistry at the Dukou section, northern margin of the Upper Yangtze. During the Late Guadalupian, the carbon isotope showed a negative drift, the marine primary productivity declined simultaneously, and redox proxies indicate the enhancement of ocean oxidation. It is worth noting that the δ13Ccarb turns into a rapid negative drift from a slow decline at approximately 260.55 Ma, which was almost synchronized with the latest reported eruption ages of Emeishan Large Igneous Province. This coincidence suggests that global volcanic-tectonic activity during the Late Guadalupian might have been the important factor in carbon-cycle perturbation. Subsequently, the δ13Ccarb presents a rapid positive shift at approximately 259.4 Ma, and climate transformed from interglacial to P4 glacial, indicating that the climate rapidly cooled before the Emeishan LIP completely ended, which may be due to carbon sinks caused by weathering of mafic rocks, and may also be associated with a significant reduction in global volcanic activity. Accompanied by sudden weathering attenuation, the 87Sr/86Sr ratios show a significant increase instead from the previous long-time low value, which only can be explained reasonably by the rapid decline in mantle-derived Sr flux associated with the weakening of volcanic activity and mafic weathering. Intergrated geochemical indices in this interval shows that there is a rapid climate perturbation associated with a significant δ13Ccarb negative shift at approximately 260.55 Ma ∼ 259.10 Ma, which may be related to the eruption surge of the Emeishan LIP, active volcanic arcs, and triggered the end-Guadalupian biocrisis.
A new method for estimating multi-source water supply considering joint probability distributions under uncertainty
Authors: Wei Chenxi , Wang Xuan , Fang Jiajia , Wang Zhijing , Li Chunhui , Liu Qiang , Yu Jingzhi 
Published: January 2023

A new method integrating techniques of copula and interval estimation to estimate multi-source water supply was proposed. Using the copula theory, joint probability distributions of multiple water sources were constructed for the estimation of water supply. In addition, the interval estimation was used to obtain the interval of water supply under uncertainty for the formulation of water-diversion strategies and the efficient allocation of water resources. This method can give an in-depth investigation on correlations and synchronous–asynchronous characteristics of runoff variations for multiple water sources, thus solving the uncertainty problem of water supply. To demonstrate its applicability, the method was applied to a case study in the Xiong’an New Area, a future metropolis in North China. The results showed that log-normal distributions for the marginal distributions of source 2 (i.e., the Water Diversion Project from the Yellow River to Baiyangdian Lake) and source 3 (i.e., the South-to-North Water Diversion Project) were feasible. The combined channel source, composed of source 2 and source 3, provided [5.20, 12.10] × 108 m3, and reservoir source provided [0.76, 3.60] × 108 m³ of water resources to the Xiong’an New Area per year. Furthermore, without the implementation of multi-source combined water supply pattern in the Xiong’an New Area, there would be a large water supply deficit. This research can provide effective practical suggestions and guidance on water-resource planning and management.
Geochemistry and zircon U–Pb ages of early Ordovician syenites from the Inexpressible Island, Antarctica and tectonic implications
Authors: Gao Peng , Tang Limei , Chen Ling 
Published: January 2023

The Ross Orogenic Belt is in the Antarctica Transantarctic Mountains. North Victoria Land Granite Harbour Intrusive complex (GHI) records the tectonic-magmatism evolution of Ross orogeny. Extensively developed post-collisional granites around this margin of early Paleozoic magmatism can provide insights into the growth of continental crust through accretionary orogenesis. We provide geochemical and geochronological data from syenites from Terra Nova Bay, north Victoria Land in order to constrain its tectonic evolution and setting. The syenite belongs to the potassium-alkaline, calc-alkaline series and is characterized by high concentrations of rare Earth elements and large ion lithophile elements (LILE), and low content in high field strength elements (Nb, Ta, P, Ti). The petrographic and geochemical signatures show a possible island-arc granite affinity. LA-ICP-MS zircon U-Pb dating results suggest that the Inexpressible Island syenite was emplaced at ca. 471.8 ± 1.8 Ma and 477.3 ± 1.7 Ma, respectively. Zircon εHf(t) values range from −7.4 to −9.1; average −8.2 and whole-rock εNd (t) values range from −8.5 to −10.3, indicating that formed by the partial melting of the lithospheric mantle enriched with subduction slab fluids and subcontinental lithosphere. Whereas, the syenite has a strong positive Eu anomaly and a positive Sr anomaly, suggesting that plagioclase cumulate crystallization occurred in the magma source area. Furthermore, through integration with previous studies, we suggest that syenite is a result of the melting zone of an older previously subduction enriched layer of the subcontinental lithospheric mantle (SCLM). To enable syenite emplacement we suggest a tectonic-magmatic model that invokes alternating phases of extension and contraction in the overriding plate. Finally, we report the youngest age of (post-orogenic) magmatism occurred during extension in the overriding plate ca. 478–471 Ma.
Influence mechanism of confining pressure on the hydraulic aperture based on the fracture deformation constitutive law
Authors: Feng Peichao , Ma Haichun , Wang Jingping , Qian Jiazhong , Luo Qiankun 
Published: January 2023

The confining pressure induces the deformation of fractures with seepage through the fracture. The seepage characteristics can reflect the deformation of the hydraulic aperture. We propose theoretical models to describe the mechanism by which the confining pressure influences the hydraulic aperture based on the fracture deformation constitutive law models of Goodman, Bandis, Sun, and Rong. Hydromechanical testing data were used to validate the four types of proposed models. The experiment results reveal the confining pressure and hydraulic aperture model based on Sun’s exponential model describes the mechanism the best. The maximum hydraulic aperture closure deformation and initial hydraulic aperture go through a growth phase with a decreasing rate, and then, they enter a stability phase when the flow rate increases to 7 ml/min, while the normal stiffness of the fracture decreases to a certain value and then tends to a stable value. Flow rate decreases as confining pressure increases in a nonlinear progression, which is described by Sun’s exponential model well. We further found that in laboratory tests at various temperatures and in field tests, the confining pressure’s influence on the hydraulic aperture is highly consistent with the model based on Sun’s model. The model developed in this study describes the mechanism by which the confining pressure influences the hydraulic aperture, and it is meaningful to rock seepage engineering with in situ stress changes at different temperatures.
Curve and double-layer economic dispatching considering reasonable wind abandonment under different time granularities
Authors: Gang Zhang , Yue Yang , Tuo Xie , She Zhang Kao , Xin He 
Published: January 2023

In view of the large output of wind power during the load trough time, the peak regulation cost may increase sharply, and the traditional hourly dispatch may not be able to accurately track the load fluctuation due to the fluctuation of renewable energy. In this paper, based on different time granularities, an adaptive segmented double-layer economic scheduling model of the net load curve considering reasonable wind abandonment is constructed. The model can better cope with net load changes while reducing the load peak-to-valley difference. First, a reasonable wind abandonment model is established under different time granularities of 5 min, 15 min, 30 min, and 1 h; Then, based on the static thinking of the net load curve by time period, the load change in the hourly scale is fully considered without changing the total number of dispatching periods so that each dispatching period can adaptively select the duration according to the change of net load gradient, and a self-adaptive subsection model of the net load curve is established to minimize the total running cost. Finally, taking IEEE-30 nodes as the example system, the NSGA-II algorithm and CPLEX solver are used to solve the model. The results verify the economy and feasibility of the proposed model.
Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan
Authors: Fan Hsien-Yu , Lin Wan-Yu , Lu Tzu-Pin , Chen Yun-Yu , Hsu Justin BoKai , Yu Sung-Liang , Su Ta-Chen , Lin Hung-Ju , Chen Yang-Ching , Chien Kuo-Liong 
Published: January 2023

Background: Left ventricular mass is a highly heritable disease. Previous studies have suggested common genetic variants to be associated with left ventricular mass; however, the roles of rare variants are still unknown. We performed targeted next-generation sequencing using the TruSight Cardio panel, which provides comprehensive coverage of 175 genes with known associations to 17 inherited cardiac conditions.Methods: We conducted next-generation sequencing using the Illumina TruSight Cardiomyopathy Target Genes platform using the 5% and 95% extreme values of left ventricular mass from community-based participants. After removing poor-quality next-generation sequencing subjects, including call rate &lt;98% and Mendelian errors, 144 participants were used for the analysis. We performed downstream analysis, including quality control, alignment, coverage length, and annotation; after setting filtering criteria for depths more than 60, we found a total of 144 samples and 165 target genes for further analysis.Results: Of the 12,287 autosomal variants, most had minor allele frequencies of &lt;1% (rare frequency), and variants had minor allele frequencies ranging from 1% to 5%. In the multi-allele variant analyses, 16 loci in 15 genes were significant using the false discovery rate of less than .1. In addition, gene-based analyses using continuous and binary outcomes showed that three genes (CASQ2, COL5A1, and FXN) remained to be associated with left ventricular mass status. One single-nucleotide polymorphism (rs7538337) was enriched for the CASQ2 gene expressed in aorta artery (p = 4.6 × 10–18), as was another single-nucleotide polymorphism (rs11103536) for the COL5A1 gene expressed in aorta artery (p = 2.0 × 10–9). Among the novel genes discovered, CASQ2, COL5A1, and FXN are within a protein–protein interaction network with known cardiovascular genes.Conclusion: We clearly demonstrated candidate genes to be associated with left ventricular mass. Further studies to characterize the target genes and variants for their functional mechanisms are warranted.
Research frontiers and trends in the application of artificial intelligence to sepsis: A bibliometric analysis
Authors: Tang Meng , Mu Fei , Cui Chen , Zhao Jin-Yi , Lin Rui , Sun Ke-xin , Guan Yue , Wang Jing-Wen 
Published: January 2023

BackgroundWith the increasing interest of academics in the application of artificial intelligence to sepsis, thousands of papers on this field had been published in the past few decades. It is difficult for researchers to understand the themes and latest research frontiers in this field from a multi-dimensional perspective. Consequently, the purpose of this study is to analyze the relevant literature in the application of artificial intelligence to sepsis through bibliometrics software, so as to better understand the development status, study the core hotspots and future development trends of this field.MethodsWe collected relevant publications in the application of artificial intelligence to sepsis from the Web of Science Core Collection in 2000 to 2021. The type of publication was limited to articles and reviews, and language was limited to English. Research cooperation network, journals, cited references, keywords in this field were visually analyzed by using CiteSpace, VOSviewer, and COOC software.ResultsA total of 8,481 publications in the application of artificial intelligence to sepsis between 2000 and 2021 were included, involving 8,132 articles and 349 reviews. Over the past 22 years, the annual number of publications had gradually increased exponentially. The USA was the most productive country, followed by China. Harvard University, Schuetz, Philipp, and Intensive Care Medicine were the most productive institution, author, and journal, respectively. Vincent, Jl and Critical Care Medicine were the most cited author and cited journal, respectively. Several conclusions can be drawn from the analysis of the cited references, including the following: screening and identification of sepsis biomarkers, treatment and related complications of sepsis, and precise treatment of sepsis. Moreover, there were a spike in searches relating to machine learning, antibiotic resistance and accuracy based on burst detection analysis.ConclusionThis study conducted a comprehensive and objective analysis of the publications on the application of artificial intelligence in sepsis. It can be predicted that precise treatment of sepsis through machine learning technology is still research hotspot in this field.
Ancestry-dependent genetic structure of the Xq28 risk haplotype in the Mexican population and its association with childhood-onset systemic lupus erythematosus
Authors: García-Ortiz Humberto , Barajas-Olmos Francisco , Flores-Huacuja Marlen , Morales-Rivera Monserrat I. , Martínez-Hernández Angélica , Baca Vicente , Contreras-Cubas Cecilia , Orozco Lorena 
Published: January 2023

ObjectiveHere we aimed to investigate the association of the Xq28 risk haplotype (H1) with susceptibility to childhood-onset systemic lupus erythematosus (SLE), and to compare its frequency and genetic structure in the Mexican population with those in other continental populations.MethodsWe genotyped 15 single-nucleotide variants (SNVs) that form the H1 haplotype, using TaqMan real-time PCR. The association analysis [case-control and transmission disequilibrium test (TDT)] included 376 cases and 400 adult controls, all of whom were mestizos (MEZ). To identify risk alleles in Mexican Indigenous individuals, SNVs were imputed from whole-exome sequencing data of 1,074 individuals. The allelic frequencies determined in MEZ and Indigenous individuals were compared with those of the continental populations from the 1,000 Genomes database phase 3. Linkage disequilibrium (LD) analysis of risk alleles was performed on all populations. Interleukin-1 receptor associated kinase 1 (IRAK1) and methyl CpG binding protein 2 (MECP2) mRNA levels were determined using real-time PCR.ResultsCase-control analysis revealed genetic association with childhood-onset SLE for all 15 SNVs (OR = 1.49–1.75; p = 0.0095 to 1.81 × 10–4) and for the Xq28 risk haplotype (OR = 1.97, p = 4 × 10–6). Comparing with individuals of European ancestry (0.14–0.16), the frequencies of the risk alleles were significantly higher in the MEZ individuals (0.55–0.68) and even higher in Indigenous individuals (0.57–0.83). LD analysis indicated a differential haplotype structure within the Indigenous groups, which was inherited to the MEZ population as a result of genetic admixture. Individuals homozygous for the Xq28 risk haplotype exhibited decreased levels of both MECP2A and B transcripts.ConclusionWe found that the H1 risk haplotype differs in its conformation in the Mexican population. This difference could be attributed to positive selection within the Indigenous population, with its inheritance now having an autoimmune health impact in both the Mexican Indigenous and MEZ populations.
Observational case-control study of small-fiber neuropathies, with regards on smoking and vitamin D deficiency and other possible causes
Authors: Fouchard Maxime , Brenaut Emilie , Genestet Steeve , Ficheux Anne-Sophie , Marcorelles Pascale , Misery Laurent 
Published: January 2023

IntroductionSmall fiber neuropathies (SFNs) are disorders of skin nerve endings inducing pruritus, burning pain, numbness, and paresthesia. The aims of this study were to search for putative etiologies of SFN and their occurrence in a cohort of patients and to compare patients with SFN to a group of patients without SFN to highlight potential factors associated with SFN.MethodsThis study was observational, retrospective, and monocentric. All patients with symptoms of SFN who underwent skin biopsies with intraepidermal nerve density counts were included. Patients with a count lower than 5 percentiles were considered to be in the SFN group. Other patients were considered to be the control group.ResultsA total of 162 patients with SFN and 161 controls were included. No cause was identified for 108 patients (61.7%). The established causes were autoimmune diseases (9.1%), diabetes or glucose intolerance (8%), medication (4%), liver disease (3.4%), and monoclonal gammopathy of undetermined significance (2.9%). Current or former smokers were more numerous in the SFN group (26.5%) than in the control group (16.1%), while vitamin D amounts were significantly lower in the SFN group than in the control group.DiscussionHence, tobacco smoking and vitamin D deficiency might be new putative causes of SFN.
Case report: Double-armed flanged polypropylene suture for repairing wide iridodialysis
Authors: Peng Tingting , Guo Huafang , Wang Yong , Zhou Li , Bao Xianyi 
Published: January 2023

PurposeTo describe a new technique for repairing wide iridodialysis (&gt;180°) with a double-armed flanged polypropylene suture.SettingPrivate practice, Wuhan, China.DesignCase report.MethodsAdjacent to the iridodialysis side, the sclera was punctured 2 mm exterior to the corneal limbus into the anterior chamber with a 30-G needle, then the root of the de-inserted iris was punctured. A 7-0 polypropylene thread was placed into the anterior chamber through a corneal incision on the opposite side and inserted into the needle. The needle was withdrawn, leaving one side of the suture out of the eye. Then, the sclera was punctured by a new needle 2 mm from the first puncture site and passed through the iris root 2 mm from the original iris puncture point. The other end of the thread was inserted into the needle and taken out of the eye. The suture was tightened to make the iris root adhere to the corneal limbus. Finally, the suture is was cut, and the ends were cauterized and left inside the sclera. This procedure can be repeated until the iridodialysis is solved.ResultsThe abovementioned technique was applied in four cases. At the end of the operations, the pupils of all patients were nearly round, with a diameter of about 3 mm. No patient suffered from intraoperative and postoperative complications.ConclusionsThe double-armed flanged polypropylene suture is a simple and safe operation method that can be applied to repair wide iridodialysis.