bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of predicting the availability of power line communication nodes using machine learning
Authors: Moussa Kareem , Amin Mennatullah Mahmoud , Darweesh M. Saeed , Said Lobna A. , Elbaz Abdelmoniem , Soltan Ahmed 
Published: August 2023

AbstractPower Line Communication technology uses power cables to transmit data. Knowing whether a node is working in advance without testing saves time and resources, leading to the proposed model. The model has been trained on three dominant features, which are SNR (Signal to Noise Ratio), RSSI (Received Signal Strength Indicator), and CINR (Carrier to Interference plus Noise Ratio). The dataset consisted of 1000 readings, with 90% in the training set and 10% in the testing set. In addition, 50% of the dataset is for class 1, which indicates whether the node readings are optimum. The model is trained with multi-layer perception, K-Nearest Neighbors, Support Vector Machine with linear and non-linear kernels, Random Forest, and adaptive boosting (ADA) algorithms to compare between statistical, vector-based, regression, decision, and predictive algorithms. ADA boost has achieved the best accuracy, F-score, precision, and recall, which are 87%, 0.86613, 0.9, 0.8646, respectively.
Impaired cecal motility and secretion alongside expansion of gut-associated lymphoid tissue in the Nlgn3R451C mouse model of autism
Authors: Lee Chalystha Yie Qin , Balasuriya Gayathri K. , Herath Madushani , Franks Ashley E. , Hill-Yardin Elisa L. 
Published: August 2023

AbstractIndividuals with Autism Spectrum Disorder (ASD; autism) commonly present with gastrointestinal (GI) illness in addition to core diagnostic behavioural traits. The appendix, or cecum in mice, is important for GI homeostasis via its function as a key site for fermentation and a microbial reservoir. Even so, the role of the appendix and cecum in autism-associated GI symptoms remains uninvestigated. Here, we studied mice with an autism-associated missense mutation in the post-synaptic protein neuroligin-3 (Nlgn3R451C), which impacts brain and enteric neuronal activity. We assessed for changes in cecal motility using a tri-cannulation video-imaging approach in ex vivo preparations from wild-type and Nlgn3R451C mice. We investigated cecal permeability and neurally-evoked secretion in wild-type and Nlgn3R451C tissues using an Ussing chamber set-up. The number of cecal patches in fresh tissue samples were assessed and key immune populations including gut macrophages and dendritic cells were visualised using immunofluorescence. Nlgn3R451C mice displayed accelerated cecal motor complexes and reduced cecal weight in comparison to wildtype littermates. Nlgn3R451C mice also demonstrated reduced neurally-evoked cecal secretion in response to the nicotinic acetylcholine receptor agonist 1,1-dimethyl-4-phenylpiperazinium (DMPP), but permeability was unchanged. We observed an increase in the number of cecal patches in Nlgn3R451C mice, however the cellular morphologies of key immune populations studied were not significantly altered. We show that the R451C nervous system mutation leads to cecal dysmotility, impaired secretion, and neuro-immune alterations. Together, these results suggest that the R451C mutation disrupts the gut-brain axis with GI dysfunction in autism.
A phenol amine molecule from Salinivenus iranica acts as the inhibitor of cancer stem cells in breast cancer cell lines
Authors: Safarpour Atefeh , Ebrahimi Marzieh , Fazeli Seyed Abolhassan Shahzadeh , Amoozegar Mohammad Ali 
Published: August 2023

AbstractIn recent years, the anticancer properties of metabolites from halophilic microorganisms have received a lot of attention. Twenty-nine halophilic bacterial strains were selected from a culture collection to test the effects of their supernatant metabolites on stem cell-like properties of six human cancer cell lines. Human fibroblasts were used as normal control. Sphere and colony formation assay were done to assess the stem cell-like properties. invasion and migration assay, and tumor development in mice model were done to assess the anti-tumorigenesis effect in vitro and in vivo. The metabolites from Salinivenus iranica demonstrated the most potent cytotoxic effect on breast cancer cell lines (IC50 = 100 µg/mL) among all strains, with no effect on normal cells. In MDA-MB-231 cells, the supernatant metabolites enhanced both early and late apoptosis (approximately 9.5% and 48.8%, respectively) and decreased the sphere and colony formation ability of breast cancer cells. Furthermore, after intratumor injection of metabolites, tumors developed in the mice models reduced dramatically, associated with increased pro-apoptotic caspase-3 expression. The purified cytotoxic molecule, a phenol amine with a molecular weight of 1961.73 Dalton (IC50 = 1 µg/mL), downregulated pluripotency gene SRY-Box Transcription Factor 2 (SOX-2) expression in breast cancer cells which is associated with resistance to conventional anticancer treatment. In conclusion, we suggested that the phenol amine molecule from Salinivenus iranica could be a potential anti-breast cancer component.
Fossils of the oldest diplodocoid dinosaur suggest India was a major centre for neosauropod radiation
Authors: Bajpai Sunil , Datta Debajit , Pandey Pragya , Ghosh Triparna , Kumar Krishna , Bhattacharya Debasish 
Published: August 2023

AbstractThe Early Jurassic and Cretaceous deposits of India are known for their diverse sauropod fauna, while little is known from the Middle and Late Jurassic. Here we report the first ever remains of a dicraeosaurid sauropod from India, Tharosaurus indicus gen. et sp. nov., from the Middle Jurassic (early–middle Bathonian) strata of Jaisalmer Basin, western India. Known from elements of the axial skeleton, the new taxon is phylogenetically among the earlier-diverging dicraeosaurids, and its stratigraphic age makes it the earliest known diplodocoid globally. Palaeobiogeographic considerations of Tharosaurus, seen in conjunction with the other Indian Jurassic sauropods, suggest that the new Indian taxon is a relic of a lineage that originated in India and underwent rapid dispersal across the rest of Pangaea. Here we emphasize the importance of Gondwanan India in tracing the origin and early evolutionary history of neosauropod dinosaurs.
Anatomically modern human in the Châtelperronian hominin collection from the Grotte du Renne (Arcy-sur-Cure, Northeast France)
Authors: Gicqueau Arthur , Schuh Alexandra , Henrion Juliette , Viola Bence , Partiot Caroline , Guillon Mark , Golovanova Liubov , Doronichev Vladimir , Gunz Philipp , Hublin Jean-Jacques , Maureille Bruno 
Published: August 2023

AbstractAround 42,000 years ago, anatomically modern humans appeared in Western Europe to the detriment of indigenous Neanderthal groups. It is during this period that new techno-cultural complexes appear, such as the Châtelperronian that extends from northern Spain to the Paris Basin. The Grotte du Renne (Arcy-sur-Cure) is a key site for discussing the biological identity of its makers. This deposit has yielded several Neanderthal human remains in its Châtelperronian levels. However, the last inventory of the paleoanthropological collection attributed to this techno-complex allowed the identification of an ilium belonging to a neonate (AR-63) whose morphology required a thorough analysis to assess its taxonomic attribution. Using geometric morphometrics, we quantified its morphology and compared it to that of 2 Neanderthals and 32 recent individuals deceased during the perinatal period to explore their morphological variation. Our results indicate a morphological distinction between the ilia of Neanderthals and anatomically modern neonates. Although AR-63 is slightly outside recent variability, it clearly differs from the Neanderthals. We propose that this is due to its belonging to an early modern human lineage whose morphology differs slightly from present-day humans. We also explore different hypotheses about the presence of this anatomically modern neonate ilium among Neanderthal remains.
Mechanisms for successful management of enterprise resource planning from user information processing and system quality perspective
Authors: Jo Hyeon , Park Do-Hyung 
Published: August 2023

AbstractEnterprise resource planning (ERP) systems are now ubiquitous in modern organizations. A number of previous studies have focused only on system factors and perceptions, there is a noticeable shortfall in research that concurrently addresses technological factors and human roles in explaining user satisfaction. This study aimed to identify these variables from the perspectives of information systems, technology, and human participation, thereby addressing this knowledge gap. The focus of the study was a large shipbuilding and marine company utilizing an ERP system. The participants, a sample of 234 ERP users, were carefully selected by the company’s executives and practitioners, and data was collected through online questionnaires. They were selected through purposive sampling from among employees who use ERP systems in large-scale shipbuilding and marine engineering companies. The study aimed to clarify the relationships between user satisfaction and perceived ease of use, perceived usefulness, system quality, service quality, participation, and information quality. A partial least squares structural equation modeling (PLS-SEM) was used to analyze the collected data. The results indicated that perceived ease of use, system quality, service quality, and participation positively influenced user satisfaction, whereas perceived usefulness did not have a significant impact. Interestingly, participation was found to lessen the effects of perceived usefulness on satisfaction. The findings of this study suggest that to enhance ERP user satisfaction, managers should strive to make the ERP system easy-to-use and stable, encourage employee participation in the decision-making process, and bolster the role of the support team. It should be noted, however, that the study has limitations as it did not consider all possible factors, such as training and support. Future research should take a broader view of the variables involved in the operation of an enterprise-wide information system.
Tasmanian devil cathelicidins exhibit anticancer activity against Devil Facial Tumour Disease (DFTD) cells
Authors: Petrohilos Cleopatra , Patchett Amanda , Hogg Carolyn J. , Belov Katherine , Peel Emma 
Published: August 2023

AbstractThe Tasmanian devil (Sarcophilus harrisii) is endangered due to the spread of Devil Facial Tumour Disease (DFTD), a contagious cancer with no current treatment options. Here we test whether seven recently characterized Tasmanian devil cathelicidins are involved in cancer regulation. We measured DFTD cell viability in vitro following incubation with each of the seven peptides and describe the effect of each on gene expression in treated cells. Four cathelicidins (Saha-CATH3, 4, 5 and 6) were toxic to DFTD cells and caused general signs of cellular stress. The most toxic peptide (Saha-CATH5) also suppressed the ERBB and YAP1/TAZ signaling pathways, both of which have been identified as important drivers of cancer proliferation. Three cathelicidins induced inflammatory pathways in DFTD cells that may potentially recruit immune cells in vivo. This study suggests that devil cathelicidins have some anti-cancer and inflammatory functions and should be explored further to determine whether they have potential as treatment leads.
Observed increase in the peak rain rates of monsoon depressions
Authors: Vishnu S. , Risser Mark D. , O’Brien Travis A. , Ullrich Paul A. , Boos William R. 
Published: August 2023

AbstractMost extreme precipitation in the densely populated region of central India is produced by atmospheric vortices called monsoon lows and monsoon depressions. Here we use satellite and gauge-based precipitation estimates with atmospheric reanalyses to assess 40-year trends in the rain rates of these storms, which have remained unknown. We show that rain rates increased in the rainiest quadrant of monsoon depressions, southwest of the vortex center; precipitation decreased in eastern quadrants, yielding no clear trend in precipitation averaged over the entire storm diameter. In an atmospheric reanalysis, ascent increased in the region of amplifying precipitation, but we could not detect trends in the intensity of rotational winds around the storm center. These storm changes occurred in a background environment where humidity increased rapidly over land while warming was more muted. Monsoon lows, which we show produce less precipitation than depressions, exhibit weaker trends that are less statistically robust.
Small EV in plasma of triple negative breast cancer patients induce intrinsic apoptosis in activated T cells
Authors: Mondal Sujan Kumar , Haas Derick , Han Jie , Whiteside Theresa L. 
Published: August 2023

AbstractSmall extracellular vesicles (sEV) in TNBC patients’ plasma promote T cell dysfunction and tumor progression. Here we show that tumor cell-derived exosomes (TEX) carrying surface PDL-1, PD-1, Fas, FasL, TRAIL, CTLA-4 and TGF-β1 induce apoptosis of CD8+T and CD4+T cells but spare B and NK cells. Inhibitors blocking TEX-induce receptor/ligand signals and TEX pretreatments with proteinase K or heat fail to prevent T cell apoptosis. Cytochalasin D, Dynosore or Pit Stop 2, partly inhibit TEX uptake but do not prevent T cell apoptosis. TEX entry into T cells induces cytochrome C and Smac release from mitochondria and caspase-3 and PARP cleavage in the cytosol. Expression of survival proteins is reduced in T cells undergoing apoptosis. Independently of external death receptor signaling, TEX entry into T cells induces mitochondrial stress, initiating relentless intrinsic apoptosis, which is responsible for death of activated T cells in the tumor-bearing hosts. The abundance of TEX in cancer plasma represents a danger for adoptively transferred T cells, limiting their therapeutic potential.
A chromosome-level genome assembly of Stenchaetothrips biformis and comparative genomic analysis highlights distinct host adaptations among thrips
Authors: Hu Qing-Ling , Ye Zhuang-Xin , Zhuo Ji-Chong , Li Jun-Min , Zhang Chuan-Xi 
Published: August 2023

AbstractInsects have a limited host range due to genomic adaptation. Thysanoptera, commonly known as thrips, occupies distinct feeding habitats, but there is a lack of comparative genomic analyses and limited genomic resources available. In this study, the chromosome-level genome of Stenchaetothrips biformis, an oligophagous pest of rice, is assembled using multiple sequencing technologies, including PacBio, Illumina short-reads, and Hi-C technology. A 338.86 Mb genome is obtained, consisting of 1269 contigs with a contig N50 size of 381 kb and a scaffold N50 size of 18.21 Mb. Thereafter, 17,167 protein-coding genes and 36.25% repetitive elements are annotated. Comparative genomic analyses with two other polyphagous thrips, revealing contracted chemosensory-related and expanded stress response and detoxification gene families in S. biformis, potentially facilitating rice adaptation. In the polyphagous thrips species Frankliniella occidentalis and Thrips palmi, expanded gene families are enriched in metabolism of aromatic and anthocyanin-containing compounds, immunity against viruses, and detoxification enzymes. These expansion gene families play crucial roles not only in adapting to hosts but also in development of pesticide resistance, as evidenced by transcriptome results after insecticides treatment. This study provides a chromosome-level genome assembly and lays the foundation for further studies on thrips evolution and pest management.
DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors
Authors: Jimmidi Ravikumar , Chamakuri Srinivas , Lu Shuo , Ucisik Melek Nihan , Chen Peng-Jen , Bohren Kurt M. , Moghadasi Seyed Arad , Versteeg Leroy , Nnabuife Christina , Li Jian-Yuan , Qin Xuan , Chen Ying-Chu , Faver John C. , Nyshadham Pranavanand , Sharma Kiran L. , Sankaran Banumathi , Judge Allison , Yu Zhifeng , Li Feng , Pollet Jeroen , Harris Reuben S. , Matzuk Martin M. , Palzkill Timothy , Young Damian W. 
Published: August 2023

AbstractThe development of SARS-CoV-2 main protease (Mpro) inhibitors for the treatment of COVID-19 has mostly benefitted from X-ray structures and preexisting knowledge of inhibitors; however, an efficient method to generate Mpro inhibitors, which circumvents such information would be advantageous. As an alternative approach, we show here that DNA-encoded chemistry technology (DEC-Tec) can be used to discover inhibitors of Mpro. An affinity selection of a 4-billion-membered DNA-encoded chemical library (DECL) using Mpro as bait produces novel non-covalent and non-peptide-based small molecule inhibitors of Mpro with low nanomolar Ki values. Furthermore, these compounds demonstrate efficacy against mutant forms of Mpro that have shown resistance to the standard-of-care drug nirmatrelvir. Overall, this work demonstrates that DEC-Tec can efficiently generate novel and potent inhibitors without preliminary chemical or structural information.
Impact of exposing lithium metal to monocrystalline vertical silicon nanowires for lithium-ion microbatteries
Authors: Refino Andam Deatama , Adhitama Egy , Bela Marlena M. , Sadhujan Sumesh , Harilal Sherina , Eldona Calvin , Bremers Heiko , Bashouti Muhammad Y. , Sumboja Afriyanti , Stan Marian C. , Winter Martin , Placke Tobias , Peiner Erwin , Wasisto Hutomo Suryo 
Published: August 2023

AbstractSilicon has attracted considerable attention for use as high-capacity anodes of lithium-ion microbatteries. However, its extreme volume change upon (de-)lithiation still poses a challenge for adoption as it leads to severe active lithium loss that shortens the cycle life. Here, we fabricate three-dimensional monocrystalline vertical silicon nanowires on a silicon wafer using low-cost metal-assisted chemical etching, then cover them with lithium using thermal evaporation prior to the battery operation as the pre-lithiation step, to investigate its impact on electrochemical performance. To reveal the underlying physical and electrochemical mechanisms, we also process a comparative planar monocrystalline silicon. We find that pre-lithiation results in improved (de-)lithiation behavior, especially in planar silicon-based cells, while silicon nanowire-based cells exhibit low capacity in early cycles. This study sheds light on the surface design and structural modification of monocrystalline silicon nanowires with respect to pre-lithiation by lithium thermal evaporation.
Trimester-specific associations of maternal dietary patterns with preterm birth: China Medical University birth cohort study
Authors: Hu Jiajin , Li Meihui , Li Chuang , Yin Shaowei , Tao Lin , Li Lin , Wan Ningyu , Liu Yilin , Liu Borui , Zheng Lu , Wang Xiaochuan , Yang Zhe , Ma Yanan , Qiao Chong , Wen Deliang , Liu Caixia 
Published: August 2023

Maternal adherence to a fish-seafood pattern in the 1st and 2nd trimester was associated with higher and lower risk of preterm birth (PTB), respectively. A dairy-egg pattern score in the 2nd or 3rd trimester was associated with higher risk of PTB.
Test–Retest Reliability of Virtual Acoustic Space Identification Test in School-Going Children
Authors: Syeda Aisha , Nisha K. V. , Jain Chandni 
Published: August 2023

Purpose:
The virtual acoustic space identification (VASI) test was designed to assess spatial-hearing acuity by simulating sound location perception in a closed field (under headphones). The utility of this tool in children can be asserted only if the test results are consistent across measurement sessions, which is evaluated in this study using test–retest reliability assessments.

Method:

The VASI test assessed the spatial abilities of 40 typically developing school-aged children aged 7–13 years (
M
age
= 10.47 ± 1.83 years, 22 boys, 18 girls). The test consisted of eight virtual location percepts (with 45° separation) produced under headphones (Sennheiser HD 569). Each spatial percept was presented randomly 7 times at 65 dB SPL. Each participant completed the assessment in three measurement sessions (baseline, intrasession, and intersession). The accuracy scores at each location and overall accuracy scores were compared across the sessions.

Results:
The Shapiro–Wilk test indicated that the VASI data were not normally distributed. Intraclass correlation coefficient analysis revealed excellent test–retest reliability of the overall accuracy scores and moderate-to-high reliability of location-specific scores. This was complimented by the low response variability of the overall and location-specific accuracy scores. The Bland–Altman analysis also indicated minimal bias in VASI accuracy scores across the three sessions.

Conclusions:
It can be concluded from the results that VASI is a reliable tool for assessing spatial-hearing acuity in school-aged children. The high test–retest reliability and ease of portability make the test highly relevant for classroom setups where early diagnosis and intervention of spatial deficits can play a critical role in determining the academic success of school-going children.
Clock synchronization based on pulse with propagation delay eliminated in wireless sensor networks
Authors: Liu Wei , Fan Ruijie , Mai Yiyuan , Wan Zehan 
Published: August 2023

AbstractClock synchronization is indispensable for numerous applications of wireless sensor networks (WSNs). When no common reference clock is available, the nodes must employ distributed synchronization techniques. This paper proposes, a distributed pulse‐based clock synchronisation approach, wherein the propagation delay is eliminated through signal ping‐pongs between neighbouring nodes. Such an approach can jointly estimate the clock skew and offset without requiring any reference clock. The whole synchronization process is completed at the physical (PHY) layer, effectively avoiding the random delay caused by packet queuing and retransmission. Simulation results show that the proposed approach can achieve higher synchronization accuracy compared with other existing methods.
Zero‐shot temporal event localisation: Label‐free, training‐free, domain‐free
Authors: Sun Li , Wang Ping , Wang Liuan , Sun Jun , Okatani Takayuki 
Published: August 2023

AbstractTemporal event localisation (TEL) has recently attracted increasing attention due to the rapid development of video platforms. Existing methods are based on either fully/weakly supervised or unsupervised learning, and thus they rely on expensive data annotation and time‐consuming training. Moreover, these models, which are trained on specific domain data, limit the model generalisation to data distribution shifts. To cope with these difficulties, the authors propose a zero‐shot TEL method that can operate without training data or annotations. Leveraging large‐scale vision and language pre‐trained models, for example, CLIP, we solve the two key problems: (1) how to find the relevant region where the event is likely to occur; (2) how to determine event duration after we find the relevant region. Query guided optimisation for local frame relevance relying on the query‐to‐frame relationship is proposed to find the most relevant frame region where the event is most likely to occur. Proposal generation method relying on the frame‐to‐frame relationship is proposed to determine the event duration. The authors also propose a greedy event sampling strategy to predict multiple durations with high reliability for the given event. The authors’ methodology is unique, offering a label‐free, training‐free, and domain‐free approach. It enables the application of TEL purely at the testing stage. The practical results show it achieves competitive performance on the standard Charades‐STA and ActivityCaptions datasets.