bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the antiviral activity of ultraviolet light and zinc oxide nanoparticles on textile products exposed to Avian coronavirus
Authors: Asmat-Campos David , Rojas-Jaimes Jesús , Icochea-D’Arrigo Eliana , Castro-Sanguinetti Gina R. , More-Bayona Juan Anderson , Juárez-Cortijo Luisa , Delfín-Narciso Daniel , Montes de Oca-Vásquez Gabriela 
Published: June 2023

AbstractThis research has developed a piece of sanitizing locker-model equipment for textiles exposed to avian coronavirus, which has been put under the influence of UV light, UV + zinc oxide nanoparticles (phytosynthesized ZnONP), and water + UV, and, in turn, under the influence of the exposure time (60, 120, 180 s). The results linked to the phytosynthesis of ZnONP indicate a novel method of fabricating nanostructured material, nanoparticles with spherical morphology and an average size of 30 nm. The assays were made based on the viral viability of avian coronavirus according to the mortality of SPF embryonated eggs and a Real-Time PCR for viral load estimation. This was a model to evaluate the sanitizing effects against coronaviruses since they share a very similar structure and chemistry with SAR-CoV-2. The influence of the type of textile treatment evidenced the potential effect of the sanitizing UV light, which achieved 100% of embryo viability. The response of the ZnONP + UV nebulization showed a notorious influence of photoactivation according to the exposure time, and the 60-s treatment achieved a decrease of 88.9% in viral viability, compared to 77.8% and 55.6% corresponding to the 120 and 180-s treatments, respectively. Regarding the decrease in viral load between the types of treatments, UV 180 s reduced 98.42% and UV 60 s + ZnONP reduced 99.46%, respectively. The results show the combinatorial effect of UV light and zinc nanoparticles in decreasing the viral viability of avian coronavirus, as a model of other important coronaviruses in public health such as SARS-CoV-2.
Optimizing fluidity and tensile strength of magnetically driven epoxy-cement repair materials based on response surface
Authors: Qin Shifu , Liu Jie , Wang Xiaoping , Yu Fan , Li Zheng , Tan Delin , Yan Qiao , Wang Lehua 
Published: June 2023

AbstractUnderwater crack repair is challenging due to drainage and exhaust, slurry retention at fixed points, and other issues. Magnetically driven epoxy resin cement slurry was developed, which can perform directional movement and fixed-point retention of slurry under the effect of an applied magnetic field. This paper focuses on slurry fluidity and tensile properties. Firstly, in the preliminary pre-study, the main influencing factors of the ratios were determined. Then, the optimum range of each factor is determined by a single-factor experiment. Furthermore, the response surface method (RSM) is applied to obtain an optimal ratio. Finally, the slurry is characterized by micro. Results showed that the evaluation index F proposed in this paper can well evaluate the interaction between fluidity (X) and tensile strength (Y). The 2FI regression model and the quadratic regression model are developed with fluidity and tensile strength as the response values and Epoxy Resin (ER) content, water-cement ratio, Fe3O4 content and sulphoaluminate cement (SAC) content as the influencing factors, and have reasonable fit and reliability. The relationship between the degree of influence of the influencing factors on the response value X and the response value Y in ascending order was: ER content > water-cement ratio > SAC content > Fe3O4 content. The magnetically driven slurry made by the optimal ratio can reach a fluidity rate of 223.31 mm and a tensile strength of 2.47 MPa. This is with relative errors of 0.36% and 1.65% from the model predicted values. Microscopic analysis showed that the magnetically driven epoxy resin cement slurry had a favorable crystalline phase, surface morphology, and structural composition.
Synergistic influence of probiotic and florfenicol on embryonic viability, performance, and multidrug-resistant Salmonella Enteritidis in broiler chickens
Authors: Nabil Nehal M. , Tawakol Maram M. , Samir Abdelhafez , Hassan Heba M. , Yonis Ahlam E. , Reda Reem M. , Elsayed Mona M. 
Published: June 2023

AbstractThis study was conducted during the period of August 2021 to April 2022 and divided into two parts. The first part involved the isolation and characterization of Salmonella from 200 diseased broiler chickens collected from farms in Dakahlia Governorate, Egypt, with the detection of its antimicrobial susceptibility. The second experimental part involved in ovo inoculation of probiotics and florfenicol to evaluate their effects on hatchability, embryonic viability, growth performance traits and the control of multidrug-resistant Salmonella Enteritidis infections post hatching. The point prevalence of Salmonella in the internal organs of diseased chickens was 13% (26/200), including 6 serotypes: S. Enteritidis, S. Typhimurium, S. Santiago, S. Colindale, S. Takoradi and S. Daula. Multidrug resistance was found in 92% (24/26) of the isolated strains with a multiantibiotic resistance index of 0.33–0.88 and 24 antibiotic resistance patterns. The in ovo inoculation of probiotic with florfenicol showed significant improvement in the growth performance parameters compared with other groups and had the ability to prevent colonization of multidrug resistant S. Enteritidis in the majority of the experimental chicks, and the remaining chicks showed very low colonization, as detected by RT‒PCR. These findings suggested the application of in ovo inoculation techniques with both probiotics and florfenicol as a promising tool to control multidrug-resistant S. Enteritidis in poultry farms.
MHD mixed convection and heatlines approach of nanofluids in rectangular wavy enclosures with multiple solid fins
Authors: Azizul Fatin M. , Alsabery Ammar I. , Hashim Ishak , Roslan Rozaini , Saleh Habibis 
Published: June 2023

AbstractTwo dimensional wavy walls rectangular cavity with inclined magnetohydrodynamic has been examined in mixed convection configurations. Triple fins arranged in the upwards ladder were filled within alumina nanoliquid in the cavity. Vertical sinusoidal walls were heated, and the other side was kept cold while both horizontal walls were kept adiabatic. All walls were motionless except the top cavity that was driven to the right. The diversified range of control parameter in Richardson number, Hartmann number, number of undulations, length of the cavity has been performed in this study. The analysis was simulated using finite element method by employing the governing equation formula, and the results were delineated in the form of streamlines, isotherms, heatlines, and comparisons on several relationships between the local velocity in the y-axis line of 0.6, local and average Nusselt number along the heated surface and dimensionless average temperature. The findings revealed that high concentration nanofluids boost the rate of heat transfer without the need to apply any magnetic field. Results found that the best heat mechanisms are natural convection with significant-high Richardson number as well as constructing two waves on the vertical walls in the cavity.
The overexpression and clinical significance of TBX15 in human gliomas
Authors: Yan Dongming , Yu Yaping , Ni Qiongwei , Meng Qingwen , Wu Haolin , Ding Shun , Liu Xiaoqian , Tang Caiying , Liu Qibing , Yang Kun 
Published: June 2023

AbstractT-box transcription factor 15 (TBX15) is upregulated in a variety of tumors and has been reported to promote uncontrolled proliferation of tumor cells and induce tumor cells to avoid apoptosis, thus accelerating the malignant transformation of malignant tumors. However, the prognostic value of TBX15 in glioma and its relationship with immune infiltration remain unknown. In this study, we intended to explore the prognostic value of TBX15 and its link to glioma immune infiltration and examine TBX15 expression in pan-cancer using RNAseq data in TPM format from TCGA and GTEx. TBX15 mRNA and protein expressions in glioma cells and adjacent normal tissue were detected and compared by RT-qPCR and Western blot. The effect of TBX15 on survival was assessed by Kaplan-Meier Method. The correlation between TBX15 upregulation and the clinicopathological characteristics of glioma patients was assessed by using TCGA databases, and the relationship between TBX15 and other genes in glioma was evaluated by using TCGA data. The top 300 genes most significantly associated with TBX15 were selected to establish a PPI network through the STRING database. The relationship between TBX15 mRNA expression and immune cell infiltration was explored by using ssGSEA and the TIMER Database. It was found that TBX15 mRNA expression in glioma tissues was significantly higher than that in the adjacent normal tissues, and this difference was most obvious in high-grade gliomas. TBX15 expression was increased in human gliomas and associated with worse clinicopathological characteristics and poorer survival prognosis in glioma patients. In addition, elevated TBX15 expression was linked to a collection of genes involved in immunosuppression. In conclusion, TBX15 played an important role in immune cell infiltration in glioma and may prove to be a predictor of the prognosis in glioma patients.
Panel of miR-150 and linc00673, regulators of CCR6/CCL20 may serve as non-invasive diagnostic marker of non-small cell lung cancer
Authors: Baran Kamila , Kordiak Jacek , Jabłoński Sławomir , Brzeziańska-Lasota Ewa 
Published: June 2023

AbstractThe C–C motif ligand 20 (CCL20) is a chemokine that specifically binds to the chemokine receptor 6 (CCR6) and the CCL20/CCR6 axis has been implicated in the non-small lung cancer (NSCLC) development and progression. Its expression is regulated by mutual interactions of non-coding RNAs (ncRNAs). This goals of presented study was to evaluate the expression level of CCR6/CCL20 mRNA in NSCLC tissue comparative to selected ncRNAs: miR-150, linc00673. The expression level of the studied ncRNAs was also assessed in serum extracellular vesicles (EVs). Thirty patients (n = 30) were enrolled as the study cohort. Total RNA was isolated from tumor tissue, adjacent macroscopically unchanged tissue and serum EVs. The expression level of studied genes and ncRNAs were estimated based on the qPCR method. Higher expression level of CCL20 mRNA but lower expression level of CCR6 mRNA were observed in tumor in comparison to control tissue. Relative to the smoking status, higher CCL20 (p < 0.05) and CCR6 mRNA (p > 0.05) expression levels were observed in current smokers than in never smokers. In serum EVs the expression level of miR-150 has a negative correlation with AJCC tumor staging, whereas the expression level of linc00673 positively correlated (p > 0.05). The lower expression level of miR-150 and higher expression level of linc00673 in serum EVs were observed in NSCLC patients with lymph nodes metastases (p > 0.05). Regarding the histopathological type, significantly lower expression level of miR-150 and higher expression level of linc00673 were observed in the serum EVs of patients with AC compared to patient with SCC. Our findings revealed that smoking significantly changed the expression level of CCL20 mRNA in NSCLC tissue. Changes in expression levels of miR-150 and linc00673 in the serum EVs of NSCLC patients in relation to presence of lymph node metastases and the stage of cancer development may serve as a non-invasive molecular biomarkers of tumor progression. Furthermore, expression levels of miR-150 and linc00673 may serve as non-intrusive diagnostic biomarkers differentiating adenocarcinoma from squamous cell carcinoma.
A reinforcement learning approach to airfoil shape optimization
Authors: Dussauge Thomas P. , Sung Woong Je , Pinon Fischer Olivia J. , Mavris Dimitri N. 
Published: June 2023

AbstractShape optimization is an indispensable step in any aerodynamic design. However, the inherent complexity and non-linearity associated with fluid mechanics as well as the high-dimensional design space intrinsic to such problems make airfoil shape optimization a challenging task. Current approaches relying on gradient-based or gradient-free optimizers are data-inefficient in that they do not leverage accumulated knowledge, and are computationally expensive when integrating Computational Fluid Dynamics (CFD) simulation tools. Supervised learning approaches have addressed these limitations but are constrained by user-provided data. Reinforcement learning (RL) provides a data-driven approach bearing generative capabilities. We formulate the airfoil design as a Markov decision process (MDP) and investigate a Deep Reinforcement Learning (DRL) approach to airfoil shape optimization. A custom RL environment is developed allowing the agent to successively modify the shape of an initially provided 2D airfoil and to observe the associated changes in aerodynamic metrics such as lift-to-drag (L/D), lift coefficient (Cl) and drag coefficient (Cd). The learning abilities of the DRL agent are demonstrated through various experiments in which the agent’s objective-maximizing L/D, maximizing Cl or minimizing Cd-as well as the initial airfoil shape are varied. Results show that the DRL agent is able to generate high performing airfoils within a limited number of learning iterations. The strong resemblance between the artificially produced shapes and those found in the literature highlights the rationality of the decision-making policy learned by the agent. Overall, the presented approach demonstrates the relevance of DRL to airfoil shape optimization and brings forward a successful application of DRL to a physics-based aerodynamics problem.
Advancing hyper-crosslinked materials with high efficiency and reusability for oil spill response
Authors: Karmelich Caleb , Wan Zhijian , Tian Wendy , Crooke Emma , Qi Xiubin , Carroll Ann , Konstas Kristina , Wood Colin 
Published: June 2023

AbstractDeveloping materials with high efficiency for recovering oil to mitigate the environmental impact of oil spills has always been a challenging task. A commercial melamine formaldehyde sponge was coated with an optimised superhydrophobic/superoleophilic hyper-crosslinked polymer and applied to the removal of crude oil from oil-in-water emulsions for the improvement of oil spill clean-up processes. The high surface area, porosity, hydrophobicity, and selectivity of oil over water made the hyper-crosslinked polymer coated sponge (HPCS) an ideal sorbent for efficient oil/water separation. The system was able to strip crude oil from water emulsions of 1000 ppm to a negligible level of 2 ppm oil with minimal amounts of the HPCS material. More importantly, the HPCS material could be reused via a simple mechanical compression process, and the uptake capacity was retained over ten cycles. For five cycles of oil adsorption/mechanical compression the HPCS was able to provide water filtrate with oil concentrations of under 15 ppm. This is an effective and economical recovery system, removing the need for consistent solvent washing and drying processes. These results suggest that the HPCS is a promising material for oil/water separation and recovery under challenging conditions.
Normal human craniofacial growth and development from 0 to 4 years
Authors: Liang Ce , Profico Antonio , Buzi Costantino , Khonsari Roman H. , Johnson David , O’Higgins Paul , Moazen Mehran 
Published: June 2023

AbstractKnowledge of human craniofacial growth (increase in size) and development (change in shape) is important in the clinical treatment of a range of conditions that affects it. This study uses an extensive collection of clinical CT scans to investigate craniofacial growth and development over the first 48 months of life, detail how the cranium changes in form (size and shape) in each sex and how these changes are associated with the growth and development of various soft tissues such as the brain, eyes and tongue and the expansion of the nasal cavity. This is achieved through multivariate analyses of cranial form based on 3D landmarks and semi-landmarks and by analyses of linear dimensions, and cranial volumes. The results highlight accelerations and decelerations in cranial form changes throughout early childhood. They show that from 0 to 12 months, the cranium undergoes greater changes in form than from 12 to 48 months. However, in terms of the development of overall cranial shape, there is no significant sexual dimorphism in the age range considered in this study. In consequence a single model of human craniofacial growth and development is presented for future studies to examine the physio-mechanical interactions of the craniofacial growth.
An antioxidant ameliorates allergic airway inflammation by inhibiting HDAC 1 via HIF-1α/VEGF axis suppression in mice
Authors: Islam Ramiya , Dash D. , Singh Rashmi 
Published: June 2023

AbstractHistone deacetylase inhibitors (HDACi) are novel class of drugs as they are involved in post translational modification of several proteins involved in signaling pathways related to asthma. HDACi have been reported to elicit protective effects on asthma but the signaling pathways associated with it have not been investigated much. Recently, we have demonstrated that intranasal administrations of Pan-HDAC inhibitors, sodium butyrate and curcumin, which have effectively reduced asthma severity via HDAC1 inhibition in Ovalbumin induced mouse model. Present study aimed to investigate possible pathways by which curcumin and sodium butyrate may minimize asthma pathogenesis via HDAC 1 inhibition. Balb/c mice were exposed (sensitized and challenged) with Ovalbumin to establish allergic asthma model followed by pretreatment of curcumin (5 mg/kg) and sodium butyrate (50 mg/kg) through intranasal route. Effects of curcumin and sodium butyrate on HIF-1α/VEGF signaling through activation of PI3K/Akt axis has been investigated using protein expressions followed by chromatin immunoprecipitation of BCL2 and CCL2 against HDAC1. Molecular docking analysis was also performed to investigate effects of curcumin and butyrate on mucus hypersecretion, goblet cell hyperplasia and airway hyperresponsiveness. Augmented expressions of HDAC-1, HIF-1α, VEGF, p-Akt and p-PI3K were observed in asthmatic group which was suppressed in both the treatments. NRF-2 level was significantly restored by curcumin and butyrate treatments. Protein expressions of p-p38, IL-5 and mRNA expressions of GATA-3 were also reduced in curcumin and butyrate treatment groups. Our findings suggest that curcumin and sodium butyrate may attenuate airway inflammation via down regulation of p-Akt/p-PI3K/HIF-1α/VEGF axis.
Localization of the ventricular pacing site from BSPM and standard 12-lead ECG: a comparison study
Authors: Sedova Ksenia A. , van Dam Peter M. , Blahova Marie , Necasova Lucie , Kautzner Josef 
Published: June 2023

AbstractInverse ECG imaging methods typically require 32–250 leads to create body surface potential maps (BSPM), limiting their routine clinical use. This study evaluated the accuracy of PaceView inverse ECG method to localize the left or right ventricular (LV and RV, respectively) pacing leads using either a 99-lead BSPM or the 12-lead ECG. A 99-lead BSPM was recorded in patients with cardiac resynchronization therapy (CRT) during sinus rhythm and sequential LV/RV pacing. The non-contrast CT was performed to localize precisely both ECG electrodes and CRT leads. From a BSPM, nine signals were selected to obtain the 12-lead ECG. Both BSPM and 12-lead ECG were used to localize the RV and LV lead, and the localization error was calculated. Consecutive patients with dilated cardiomyopathy, previously implanted with a CRT device, were enrolled (n = 19). The localization error for the RV/LV lead was 9.0 [IQR 4.8–13.6] / 7.7 [IQR 0.0–10.3] mm using the 12-lead ECG and 9.1 [IQR 5.4–15.7] / 9.8 [IQR 8.6–13.1] mm for the BSPM. Thus, the noninvasive lead localization using the 12-lead ECG was accurate enough and comparable to 99-lead BSPM, potentially increasing the capability of 12-lead ECG for the optimization of the LV/RV pacing sites during CRT implant or for the most favorable programming.
A fast magnetic vector characterization method for quasi two-dimensional systems and heterostructures
Authors: Herguedas-Alonso A. E. , Aballe L. , Fullerton J. , Vélez M. , Martín J. I. , Sorrentino A. , Pereiro E. , Ferrer S. , Quirós C. , Hierro-Rodriguez A. 
Published: June 2023

AbstractThe use of magnetic vector tomography/laminography has opened a 3D experimental window to access the magnetization at the nanoscale. These methods exploit the dependence of the magnetic contrast in transmission to recover its 3D configuration. However, hundreds of different angular projections are required leading to large measurement times. Here we present a fast method to dramatically reduce the experiment time specific for quasi two-dimensional magnetic systems. The algorithm uses the Beer-Lambert equation in the framework of X-ray transmission microscopy to obtain the 3D magnetic configuration of the sample. It has been demonstrated in permalloy microstructures, reconstructing the magnetization vector field with a reduced number of angular projections obtaining quantitative results. The throughput of the methodology is × 10–× 100 times faster than conventional magnetic vector tomography, making this characterization method of general interest for the community.
Greenhouse gas emission potential of sewage treatment plants in Himachal Pradesh
Authors: Sharma Apurva , Bhardwaj Satish Kumar , Aggarwal R. K. , Sharma Ravinder , Agrawal Ghanshyam 
Published: June 2023

AbstractIn recent times, waste management has emerged as a significant environmental challenge, and sewage is among the major contributors due to the rapidly increasing population. Despite sewage treatment plants (STPs) being the solution for the treatment of sewage, they have been identified as sources of greenhouse gas (GHG) emissions. This study aimed to estimate the contribution of STPs to GHG emissions in the state. This was achieved by visiting the sites, filling scientifically designed questionnaires, sample collection as well as computational methods by Intergovernmental Panel on Climate Change. The assessment of direct and indirect emissions from the STPs revealed that emissions were caused by the activated sludge process, electricity consumption, transportation, and sludge storage. Electricity consumption by STPs was responsible for the highest emissions, accounting for 43% of the total emissions, equivalent to 20,823 tCO2 eq. The activated sludge process contributed 31% (14,934 tCO2 eq) of the emissions, while storage of sludge in landfills accounted for 24% (11,359 tCO2 eq). Additionally, transportation contributed 2% (1121 tCO2 eq) of the emissions. In total, the STPs in Himachal Pradesh had the potential to contribute 48,237 tCO2 eq GHG emissions annually. Thus, the study suggests process-level modifications in STPs of Himachal Pradesh to mitigate GHG emissions. This research provides insight into the GHG emissions from STPs and highlights the need for their management to reduce environmental impacts.