bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complexity science: A framework for psychotherapy integration
Authors: Schiepek Günter , Pincus David 
Published: April 2023

AbstractThe paradigm of complexity science provides a new way to address the problem of psychotherapy integration and allows us to bypass the various shortcomings of the linear‐interventionist perspective. Nine criteria are outlined, which should be satisfied by any integrative approach to psychotherapy: (a) the use of complexity science to provide a meta‐theoretical and generic understanding of change processes (from neuronal to social system levels); (b) a comprehensive and formalised modelling of change processes and personality development; (c) an integrative method of case formulation; (d) the ability to understand a variety of techniques in terms of basic change principles; (e) criteria to guide microdecisions; (f) the application of data‐driven feedback and real‐time monitoring of change dynamics; (g) standardised assessment of outcomes in naturalistic settings; (h) guidelines for training; and (i) strategies that are well‐suited to science–practice integration. Using these criteria as a framework for evaluation, one may grasp the potential of complexity science to drive innovation in the pursuit of psychotherapy integration.
A practice‐based exploration of therapeutic change in a charitable, community‐based person‐centred counselling service using routine outcome measures of anxiety and depression. I: Statistical and clinically significant change
Authors: Young Jennifer , Widdowson Mark , Tate David 
Published: April 2023

AbstractBackgroundEstablishing the value of differing treatments for depression and anxiety is crucial in a climate of delimited spending and increased demand. Drawing from a well‐founded, diverse evidence base is salient to constructive evaluation and any subsequent recommendations being fit for purpose.DesignThis study employed a practice‐based quantitative design to explore therapeutic gains in adult counselling clients attending person‐centred therapy (n = 301), delivered in a charitable, community‐based UK service.MeasuresOutcome measures PHQ‐9 and GAD‐7 were used from three time points: initial assessment (IA), first ongoing session and last or 6th ongoing appointment (whichever occurred first; T1, T2 and T3).AnalysisRepeated measures ANOVA, CSI, RI and RCSI calculations were used to consider significant change in clients.FindingsReductions in PHQ‐9 and GAD‐7 outcome measures were observed over time (between T2 & T3 and T1 & T3) and were all statistically significant (p = <0.001). By T3: CSI was achieved by 48.1% of clients on PHQ‐9 and 50.8% of clients on GAD‐7, RI was achieved by 47.8% of clients on PHQ‐9 and 60.5% of clients on GAD‐7, and RCSI was achieved by 32.6% of clients on PHQ‐9 and 41.2% of clients on GAD‐7.ConclusionsThe treatment observed resulted in effective outcomes equivalent to other therapies reviewed in the literature for clients' symptoms of anxiety and depression as measured by GAD‐7 and PHQ‐9.
The shifting sound of silence: A constructivist grounded theory
Authors: Montgomery Michael R. , Luca Maria , Gordon‐Finlayson Alasdair 
Published: April 2023

AbstractData on the use of silence from a therapist's perspective remain limited. This study aimed to develop an understanding of psychotherapists' use of silence in clinical settings. Practising psychotherapists were interviewed about their experiences of silence, and a constructivist grounded theory approach was adopted to arrive at a substantive theoretical understanding of psychotherapists' silence. A grounded theory analysis supported the construction of a theory conceptualised into four main categories: conditions (evolving disparity, rendering relationships and minding the gap), cornerstones (sensitising silence, productive comforting, productive discomforting and temperature gauging), consequences (deepening the treatment) and considerations (timing and silently experiencing). Silence is intersubjective and effective in clinical settings, and the results of the current study indicate that silence is powerful and ambiguous and is best used later in treatment when a strong therapeutic alliance is in place. Individual comfort and the needs of the client were found to be more significant than any single modality or theory. Silence is used to create a space in which treatment can be deepened through the presence of a therapist and mutual introspection. This study recommends a greater focus on a contemporary use of silence during the training and education of psychotherapists, and the importance of free association should be addressed earlier in clinician training. This theory requires further exploration of patients' experiences to establish their correspondence.
A case of necrotizing enterocolitis in full‐term infant on his first day of life—Early presentation with multifactorial etiology
Authors: Bednarczyk Małgorzata Maria , Żelazna Olga , Głuszczak‐Idziakowska Ewa , Schreiber‐Zamora Joanna , Furmanek Mariusz , Kociszewska‐Najman Bożena 
Published: April 2023

AbstractWe aimed to show the complexity of NEC in the full‐term newborns. Additionally, we wanted to underline the importance of breastfeeding from the first day of life and show how deteriorating effect the antibiotics can have on gastrointestinal tract.
Sclerosing epithelioid fibrosarcoma of the foot: A case report
Authors: Mremi Alex , Sadiq Adnan , Goodluck Gregory , Lodhia Jay 
Published: April 2023

AbstractSclerosing epithelioid fibrosarcoma (SEF) is a rare and distinctive variant of fibrosarcoma. To date, about 100 cases only have been documented. Histopathologically, it resembles a variety of benign, pseudosarcomatous and other malignancies. Early diagnosis and treatment are vital for improving the treatment outcomes.
Harnessing Clickable Acylated Glycerol Probes as Chemical Tools for Tracking Glycerolipid Metabolism
Authors: Ancajas Christelle F. , Carr Adam J. , Lou Jinchao , Sagar Ruhani , Zhou Yue , Reynolds Todd B. , Best Michael D. 
Published: April 2023

AbstractWe report the use of clickable monoacylglycerol (MAG) analogs as probes for the labeling of glycerolipids during lipid metabolism. Incorporation of azide tags onto the glycerol region was pursued to develop probes that would label glycerolipids, in which the click tag would not be removed through processes including acyl chain and headgroup remodeling. Analysis of clickable MAG probes containing acyl chains of different length resulted in widely variable cell imaging and cytotoxicity profiles. Based on these results, we focused on a probe bearing a short acyl chain (C4‐MAG‐N3) that was found to infiltrate natural lipid biosynthetic pathways to produce click‐tagged versions of both neutral and phospholipid products. Alternatively, strategic blocking of the glycerol sn‐3 position in probe C4‐MEG‐N3 served to deactivate phospholipid tagging and focus labeling on neutral lipids. This work shows that lipid metabolic labeling profiles can be tuned based on probe structures and provides valuable tools for evaluating alterations to lipid metabolism in cells.
Tool Chain to Extract and Contextualize Process Data for AI Applications
Authors: Sherpa Lincoln , Müller-Pfefferkorn Ralph , Enste Udo , Tolksdorf Gregor , Kawohl Michael , Wiedau Michael 
Published: April 2023

AbstractSummarizing a key use case of a research workstream of the German publicly funded KEEN project, methods and tool chains are demonstrated to extract and to contextualize process data in an automated way based on engineering information. The contextualized process data serves as a high‐quality data source for machine learning methods. The article covers the applied basic methodical approaches, design decisions and the results of a successful pilot installation of the developed tool chain.
Promoting Oxygen Reduction Reaction on Carbon‐based Materials by Selective Hydrogen Bonding
Authors: Yang Li , Zhang Yue , Huang Yan , Deng Linjie , Luo Qiquan , Li Xiyu , Jiang Jun 
Published: April 2023

AbstractElectrochemical oxygen reduction reaction (ORR) is fundamental for many energy conversion and storage devices. Selective tuning of *OOH/*OH adsorption energy to break the intrinsic scaling limitation (ΔG*OOH=ΔG*OH+3.2 eV) is effective in optimizing the ORR limiting potential (UL), which is practically challenging to achieve by constructing a particular catalyst. Herein, using first‐principles calculations, we elucidated how to rationally plant an additional *OH that can selectively interact with the ORR intermediate of *OOH via hydrogen bonding, while not affecting the *OH intermediate. Guided by the design principle, we successfully tailored a series of novel carbon‐based catalysts, with merits of low‐cost, long‐lasting, synthesis feasibility, exhibiting a high UL (1.06 V). Our proposed strategy comes up with a new linear scaling relationship of ΔG*OOH=ΔG*OH+2.84 eV. This approach offers a great possibility for the rational design of efficient catalysts for ORR and other chemical reactions.
Frequency‐adapted hybrid modulation strategy of resonant converter with narrow frequency range
Authors: Chen Zhangyong , Zhu Xintong , Chen Gen , Chen Yong , Feng Chenchen 
Published: April 2023

SummaryResonant converters have been widely applied in many fields, such as electric vehicles, renewable energy sources, and switch‐mode power supply. Conventional resonant converters generally adopt pulse frequency modulation (PFM), which would cause an extremely wide frequency variation range under wide output applications. However, it would lead to high electromagnetic interference (EMI), low utilization of magnetic components, and loss of soft switching features. For catering to wide output range applications, this paper proposes a self‐adaptive narrow frequency range PFM and asymmetrical voltage‐cancelation hybrid modulation strategy to solve the above problem. The advantages of the proposed strategy include (1) narrow frequency variation range; (2) self‐adaptive shift frequency; and (3) full process achievement of zero voltage switch. The modulation strategy and operational principle and performance analysis of the proposed method are given. Eventually, a series resonant converters–based experimental platform was implemented to verify the proposed strategy.
Minimal seven‐element series‐parallel realizability of a certain positive‐real biquadratic impedance
Authors: Wang Kai , Chen Michael Z. Q. , Liu Fei 
Published: April 2023

SummaryThe minimal complexity realization of low‐order positive‐real immittances as resistor–inductor–capacitor (RLC) (or damper‐spring‐inerter) networks is an essential unsolved problem in the theory of network synthesis, and the results can be directly applied to the inerter‐based mechanical systems control. This paper solves the realizability problem of a certain class of biquadratic impedances as any seven‐element series‐parallel RLC network, where the impedance contains a repeated zero and pole of multiplicity two. In contrast to the previous results of this problem, the work in this paper considers the general case and removes the restrictions on the network structures and the number of reactive elements. The final results present a necessary and sufficient condition for the realizability of such an impedance as any seven‐element series‐parallel RLC network. A network synthesis example in suspension control design is presented to illustrate the results of this paper and the applications in inerter‐based mechanical control.
High‐grade squamous intraepithelial lesion cervicovaginal paps with negative high‐risk HPV testing, a prospective study with histological follow‐up
Authors: Agoff S. Nicholas , Brockmeyer Amy D. , Barrie Allison M. , Larson Julie 
Published: April 2023

AbstractBackgroundHigh‐risk human papillomavirus (hrHPV) testing has become integral in the screening and treatment protocols for cervical neoplasia. Stand‐alone HPV testing is advocated as a screening tool for cervical neoplasia. However, negative hrHPV tests with diagnosis of high‐grade squamous intraepithelial lesion or worse (≥HSIL) have been reported. We report our experience with paps diagnosed as HSIL, negative hrHPV testing, and subsequent follow‐up.MethodsOf 303 women with HSIL diagnosed on ThinPrep pap between 2019 and 2023, 84 (28%) were tested for hrHPV by Roche Cobas. Repeat testing was performed at a referral center. Immunohistochemistry (IHC) for p16 was performed on follow‐up biopsies and hrHPV in‐situ hybridization.ResultsOf 84 HSIL cases, 8 were hrHPV negative. Follow‐up biopsies available in 7 cases were ≥HSIL (1 with invasive squamous cell carcinoma, 1 endocervical adenocarcinoma in situ). Follow‐up HSIL was found on additional cases of HPV negative atypical glandular cells favor neoplastic and atypical squamous cells favor HSIL. IHC for p16 was positive on all biopsies. hrHPV FISH was negative.ConclusionsOur experience with hrHPV testing by Roche Cobas demonstrates that some morphologically diagnostic HSIL paps are hrHPV negative: 8.3% of HSIL paps with subsequent histological HSIL were HPV negative. The index case caused concern among our clinical colleagues. Positive staining for p16 is highly suggestive of HPV induced disease. Possible reasons for negative hrHPV testing could include non‐hrHPV types, low HPV DNA levels, or HPV types not included in the Cobas testing panel.
Detection of gonadotropin‐releasing hormone and its analogues in equine and canine urine by high‐resolution data‐independent acquisition
Authors: Timms Mark , Botteon Antony , Manos Christian , Griffin Joshua , Levina Vita , Steel Rohan 
Published: April 2023

AbstractGonadotropin‐releasing hormone (GnRH) and its synthetic analogues are considered banned substances by the racing industry. GnRH is used as a pharmaceutical to regulate the female oestrous cycle, but the hormone is also thought to increase the production of testosterone in male animals. Using liquid chromatography in conjunction with high‐resolution mass spectrometry (LC–HRMS) and data‐independent acquisition (DIA), a method is presented for the detection of intact and truncated peptides of GnRH and its analogues down to the low picogram level in equine urine. The study of the catabolism of GnRH and analogues in plasma, combined with the analysis of urine from administration studies, reveals a common pattern of peptide catabolites that can be used to guide the design of MS‐based screens for this class of drugs. This culminated in the successful detection of the peptide in two out‐of‐competition canine urine samples.
Clonally expanded PD‐1‐expressing T cells are enriched in synovial fluid of juvenile idiopathic arthritis patients
Authors: Vanni Anna , Mazzoni Alessio , Semeraro Roberto , Capone Manuela , Maschmeyer Patrick , Lamacchia Giulia , Salvati Lorenzo , Carnasciali Alberto , Farahvachi Parham , Giani Teresa , Simonini Gabriele , Filocamo Giovanni , Romano Micol , Liotta Francesco , Mashreghi Mir‐Farzin , Cosmi Lorenzo , Cimaz Rolando , Magi Alberto , Maggi Laura , Annunziato Francesco 
Published: April 2023

AbstractJuvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in childhood. The disease etiology remains largely unknown; however, a key role in JIA pathogenesis is surely mediated by T cells. T‐lymphocytes activity is controlled via signals, known as immune checkpoints. Delivering an inhibitory signal or blocking a stimulatory signal to achieve immune suppression is critical in autoimmune diseases. However, the role of immune checkpoints in chronic inflammation and autoimmunity must still be deciphered. In this study, we investigated at the single‐cell level the feature of T cells in JIA chronic inflammation, both at the transcriptome level via single‐cell RNA sequencing and at the protein level by flow cytometry. We found that despite the heterogeneity in the composition of synovial CD4+ and CD8+ T cells, those characterized by PD‐1 expression were clonally expanded tissue‐resident memory (Trm)‐like cells and displayed the highest proinflammatory capacity, suggesting their active contribution in sustaining chronic inflammation in situ. Our data support the concept that novel therapeutic strategies targeting PD‐1 may be effective in the treatment of JIA. With this approach, it may become possible to target overactive T cells regardless of their cytokine production profile.
Spin‐Crossover Iron(II) Compounds with Pendent Tetraphenylethylene Group
Authors: Shi Shi‐Hang , Hu Jie‐Sheng , Tao Jun 
Published: April 2023

AbstractTwo iron(II) compounds with the general formula of [Fe(phen‐TPE)2(NCX)2] ⋅ Y (phen‐TPE=3‐(tetraphenylethylene)‐1,10‐phenanthroline; X=S and Y=2DMF for 1 ⋅ 2DMF; X=Se and Y=DMF for 2 ⋅ DMF) were synthesized and characterized by single‐crystal X‐ray crystallography and magnetic measurements. Both compounds exhibited thermal‐induced complete one‐step spin‐crossover (SCO) behavior with the critical transition temperatures of 210 K and 260 K for 1 ⋅ 2DMF and 2 ⋅ DMF, respectively. The SCO behavior of these two isomorphic compounds depended significantly on robust intermolecular π⋅⋅⋅π interactions, NCX− groups and solvent molecules.
Characterizing biased visuospatial perception in complex regional pain syndrome
Authors: Filbrich Lieve , Kuzminova Avgustina , Molitor Victoria , Verfaille Charlotte , Mouraux Dominique , Berquin Anne , Barbier Olivier , Libouton Xavier , Legrain Valéry 
Published: April 2023

AbstractBackgroundPatients suffering from complex regional pain syndrome (CRPS) are increasingly shown to be affected by cognitive difficulties. While these cognitive symptoms were initially described as limited to the perception, representation and use of the body, that is, the somatic space, they were recently shown to also extend to the perception of extra‐somatic space. CRPS patients seem indeed to pay less attention to visual stimuli occurring in the same side of space as their affected limb and especially those occurring close to that limb. The aim of the present study was to more precisely characterize these visuospatial biases, by investigating whether they may be dependent on the visually perceived proximity between the visual stimuli and the affected limb.MethodsUpper‐limb CRPS patients and matched control participants performed temporal order judgements on visual stimuli, one presented in either side of space, while they could either see their hands near the visual stimuli or not.ResultsVisuospatial biases were not modulated by the availability of visual feedback about the hands. However, secondary analyses revealed that these biases depended on the type of rehabilitation program that the patients followed: whereas patients who did not follow any specific program presented significant biases to the detriment of visual stimuli in the affected side of space, patients who did follow a CRPS‐specialized program did not.ConclusionsPatients' cognitive strategies will be important to consider when studying inter‐individual differences in the cognitive symptomatology and associated cognitive‐based rehabilitation procedures in CRPS.SignificanceThe existence of biases in visuospatial perception in Complex Regional Pain Syndrome has been reported but not always systematically replicated. We show that these biases might depend on the type of general rehabilitation program that the patients follow. Patients’ individual cognitive strategies will be important to consider when studying the cognitive symptomatology of CRPS.
A model‐driven method based on multisource data for reproducing displacement time history
Authors: He Zhizhou , Wang Haishen , Pan Peng 
Published: April 2023

AbstractThe seismic displacement time history of a structure is very important for damage assessment. This paper proposes a displacement estimation method based on multisource measurement data. In this method, the structure is simplified to a mass‐spring shear model, where a set of tunable parameters are assigned. The particle swarm optimization algorithm is used to search for the optimal values of the parameters, and the objective of the optimization problem is to minimize the difference between the measured roof response and that calculated by the model. A refined finite element model was established in ABAQUS, and the numerical calculation results were used to verify this proposed method. Results show that the estimation error of the maximum inter‐story drift ratio among all floors is 8.9%, and the average error of the maximum displacement of each floor is 7.0%, representing a satisfactory estimation effectiveness. The source of the errors is discussed, and we find that this method is more suitable for low‐rise buildings. Shaking table tests of a scaled four‐story reinforced concrete (RC) frame were conducted, and the estimation error of the maximum inter‐story drift ratio among all floors was 6.1%, indicating the feasibility of this method in practice.
Genesis of subglacial triangular‐shaped landforms (murtoos) formed by the Fennoscandian Ice Sheet
Authors: Mäkinen Joni , Kajuutti Kari , Ojala Antti E. K. , Ahokangas Elina , Tuunainen Aleksi , Valkama Markus , Palmu Jukka‐Pekka 
Published: April 2023

AbstractThe purpose of this paper is to describe the internal structure and composition of recently discovered subglacial landforms called “murtoos” in order to interpret their formative processes and depositional environment. So far, murtoos have only been reported from Finland and Sweden, but they probably exist in all areas covered by past ice sheets. Murtoos mainly occur in fields along subglacial meltwater routes or corridors in close relation to eskers and ribbed moraine tracts. Murtoos were excavated perpendicular to the long axes of the triangular murtoo heads in six locations. Murtoos were found to be composed of silt/clay‐poor, sandy and gravelly diamictons interbedded with sorted sediments, and are suggested to be produced by pulsed, highly sediment‐concentrated flows during weak glaciotectonic deformation, indicating effective pressure close to zero. Murtoos can be divided into three main depositional units: 1) the core, 2) the murtoo body and 3) the murtoo mantle. The initial deposition of murtoos took place in a network of low canals and conduits or cavities with fluctuating stream flow likely over 50 km from the ice margin. Murtoos reveal an increasing influence of subglacial meltwater flow in rapidly widening broad and low conduits with increasing sediment transport over short distances. The results of this work suggest that murtoos were formed time‐transgressively over yearly meltwater cycles in a semi‐distributed drainage system not recognised before, in which was high‐pressure porewater conditions with rapid mobilisation of subglacial saturated sediments, a critical factor in the development of semi‐efficient drainage. Murtoos are suggested as missing element between distributed and channelised drainage systems not included in current glaciohydrological models or even in the theoretical basis of glacial hydrology.