bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Self-Reported Adherence to Healthy Lifestyle Behaviors Among US Adults, 1999 to March 2020
Authors: Li Yue , Xia Peng-Fei , Geng Ting-Ting , Tu Zhou-Zheng , Zhang Yan-Bo , Yu Han-Cheng , Zhang Ji-Juan , Guo Kunquan , Yang Kun , Liu Gang , Shan Zhilei , Pan An 
Published: July 2023

ImportanceAdherence to a healthy lifestyle is associated with lower risks of adverse outcomes. However, trends in multiple lifestyle factors and overall healthy lifestyle status among US adults in recent years are unknown.ObjectiveTo examine trends in multiple lifestyle factors and overall healthy lifestyle among US adults.Design, Setting, and ParticipantsThis serial cross-sectional study used nationally representative data from 10 National Health and Nutrition Examination Survey (NHANES) cycles (nine 2-year cycles from 1999 to 2016 and 1 combined cycle from 2017 to March 2020) among adults 20 years or older. Data were analyzed from December 10, 2021, to January 11, 2023.ExposureSurvey cycle.Main Outcomes and MeasuresFive healthy lifestyle factors: never smoking, moderate or lighter alcohol consumption (for women: ≤7 drinks/wk; for men: ≤14 drinks/wk), healthy diet (Healthy Eating Index–2015 scores ≥60.0), sufficient physical activity (≥150 min/wk of equivalent moderate physical activity), and healthy weight (body mass index [calculated as weight in kilograms divided by height in meters squared] 18.5-24.9).ResultsA total of 47 852 adults were included in this study. The weighted mean [SE] age was 47.3 [0.2] years; 24 539 (weighted proportion, 51.5%) were women. From the 1999-2000 cycle to the 2017 to March 2020 cycle, the estimated prevalence of the 5 lifestyle factors showed divergent trends, with increasing prevalence of never smoking (from 49.4% [95% CI, 46.4%-52.4%] to 57.7% [95% CI, 55.5%-59.9%]; difference, 8.2% [95% CI, 4.5%-12.0%]), healthy diet (from 19.3% [95% CI, 16.0%-22.6%] to 24.5% [95% CI, 21.5%-27.5%]; difference, 5.2% [95% CI, 0.8%-9.7%]), and sufficient physical activity (from 55.7% [95% CI, 51.8%-59.6%] to 69.1% [95% CI, 67.2%-71.1%]; difference, 13.4% [95% CI, 9.0%-17.8%]), while prevalence of healthy weight decreased from 33.1% (95% CI, 30.5%-35.6%) to 24.6% (95% CI, 22.6%-26.7%; difference, −8.4% [95% CI, −11.8% to −5.1%]) (allP &amp;lt; .001 for trend). Meanwhile, there was no significant trend in moderate or lighter alcohol consumption. Overall, the estimated prevalence of at least 4 healthy lifestyle factors increased from 15.7% (95% CI, 12.8%-18.7%) to 20.3% (95% CI, 17.8%-22.7%; difference, 4.5% [95% CI, 0.7%-8.4%];P &amp;lt; .001 for trend). Disparities in healthy lifestyle were widened by age group, with little improvement among adults 65 years and older (difference, 0.04% [95% CI, −4.28% to 4.35%]). There were persistent disparities in healthy lifestyle by race and ethnicity, educational level, and income level.Conclusions and RelevanceThe findings of this cross-sectional study of NHANES data over a 22-year period suggest diverse change patterns across 5 healthy lifestyle factors and a modest improvement in overall lifestyle existed among US adults, with worsening or persistent disparities in lifestyle.
Synthesis of Carboxylic Acids from Benzamide Precursors Using Nickel Catalysis
Authors: Bulger Ana S. , Witkowski Dominick C. , Garg* Neil K. 
Published: July 2023

AbstractThis chapter describes the procedure for synthesis of carboxylic acids from benzamide precursors using nickel catalysis. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. Carboxylic acids are ubiquitous functional groups found in natural products and drugs but can be difficult to carry through multistep syntheses due to their acidity. Many methods for accessing carboxylic acids proceed from oxidation of alcohols or aldehydes to the corresponding carboxylic acid, but methods to access carboxylic acids from amide precursors are limited. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards.
A scoping review of workplace health promotion interventions for chronic diseases in Australia
Authors: Arnold Leonie , Harris Katherine , Weale Victoria 
Published: July 2023

Abstract

Objective
The aim of this study is to systematically chart and summarize the literature pertaining to workplace health promotion (WHP) interventions targeting the five main modifiable lifestyle risk factors for chronic disease, including smoking, nutrition, alcohol, physical activity, overweight/obesity (SNAPO) in Australian workers.

Methods
A scoping review was performed using the framework of Arksey and O’Malley. MEDLINE, EMBASE, CINAHL, and SCOPUS were searched to identify peer-reviewed publications that evaluated primary or secondary WHP interventions which targeted one or more modifiable risk factor (SNAPO).

Results
A total of fifty-six articles were included in the review. The findings revealed a heterogeneous nature of WHP intervention design and evaluation. The majority of the interventions focussed on physical activity, with fewer targeting the other four main modifiable risk factors. Health care and white-collar workers were most frequently targeted, with less attention paid to other worker groups. The review also found that many interventions had a duration of three months or less.

Conclusions
Significant gaps have been identified in relation to the occupational role, risk factors targeted, and intervention length. This review also highlights the need for further research to be conducted to determine the efficacy of interventions to facilitate the development of a framework for WHP interventions to reduce the risk and prevalence of chronic disease.
Realizing an Unprecedented Fill Factor of 82.2% in Ternary Organic Solar Cells via Co‐Crystallization of Non‐Fullerene Acceptors
Authors: Chen Chen , Wang Liang , Sun Yuandong , Fu Yiwei , Guo Chuanhang , Zhou Bojun , Gan Zirui , Liu Dan , Li Wei , Wang Tao 
Published: July 2023

AbstractTernary strategy is demonstrated as an efficient approach to achieve high short‐circuit current and open‐circuit voltage to boost the performance of organic solar cells (OSCs), however, the realization of high fill‐factor (FF) in ternary OSCs has been rare. In this study, three thiophene terminated non‐fullerene acceptors (NFAs) with methyl or chlorine substitutions on their end‐groups are designed and synthesized, and further incorporated into the state‐of‐the‐art PM6:L8‐BO system to construct ternary OSCs. Subtle changes in their chemical structures significantly modify the molecular packings of these thiophene terminated NFAs. While BTP‐ThMe and BTP‐ThCl have limited forms of dimer, versatile molecular dimers, including “Z” shaped D‐D, “S” shaped A‐A, and “F” shaped A‐D packings exist in BTP‐ThMeCl, which lead to the formation of compact 3D honey‐comb network and this is analogous to the host acceptor L8‐BO. This synergetic molecular packing between BTP‐ThMeCl and L8‐BO contributes to maintain the 3D charge transport network in the ternary system via the formation of NFA co‐crystals at the molecular level, and consequently realizing a maximum power conversion efficiency of 19.1% with a superior FF of 82.2%, which is the highest FF reported so far for OSCs.
Programmable Peptides Activated Macropinocytosis for Direct Cytosolic Delivery
Authors: Fan Yan‐Lei , Zhang Ni‐Yuan , Hou Da‐Yong , Hao Yi , Zheng Rui , Yang Jia , Fan Zhi , An Hong‐Wei , Wang Hao 
Published: July 2023

AbstractBioactive macromolecules show great promise for the treatment of various diseases. However, the cytosolic delivery of peptide‐based drugs remains a challenging task owing to the existence of multiple intracellular barriers and ineffective endosomal escape. To address these issues, herein, programmable self‐assembling peptide vectors are reported to amplify cargo internalization into the cytoplasm through receptor‐activated macropinocytosis. Programmable self‐assembling peptide vector‐active human epidermal growth factor receptor‐2 (HER2) signaling induces the receptor‐activated macropinocytosis pathway, achieving efficient uptake in tumor cells. Shrinking macropinosomes accelerate the process of assembly dynamics and form nanostructures in the cytoplasm to increase peptide‐based cargo accumulation and retention. Inductively coupled plasma mass (ICP‐MS) spectrometry quantitative analysis indicates that the Gd delivery efficiency in tumor tissue through the macropinocytosis pathway is improved 2.5‐fold compared with that through the use of active targeting molecular delivery. Finally, compared with nanoparticles and active targeting delivery, the delivery of bioactive peptide drugs through the self‐assembly of peptide vectors maintains high drug activity (the IC50 decreased twofold) in the cytoplasm and achieves effective inhibition of tumor cell growth. Programmable self‐assembling peptide vectors represent a promising platform for the intracellular delivery of diverse bioactive drugs, including molecular drugs, peptides, and biologics.
In Situ Li‐Plating Diagnosis for Fast‐Charging Li‐Ion Batteries Enabled by Relaxation‐Time Detection
Authors: Xu Lei , Xiao Ye , Yang Yi , Xu Rui , Yao Yu‐Xing , Chen Xiao‐Ru , Li Ze‐Heng , Yan Chong , Huang Jia‐Qi 
Published: July 2023

AbstractThe Li‐plating behavior of Li‐ion batteries under fast‐charging conditions is elusive due to a lack of reliable indicators of the Li‐plating onset. In this work, the relaxation time constant of the charge‐transfer process (τCT) is proposed to be promising for the determination of Li‐plating onset. A novel pulse/relaxation test method enables rapid access to the τCT of the graphite anode during battery operation, applicable to both half and full batteries. The diagnosis of Li plating at varying temperatures and charging rates enriches the cognition of Li‐plating behaviors. Li plating at low temperatures and high charging rates can be avoided because of the battery voltage limitations. Nevertheless, after the onset, severe Li plating evolves rapidly under harsh charging conditions, while the Li‐plating process under benign charging conditions is accompanied by a simultaneous Li‐intercalation process. The quantitative estimates indicate that Li plating at high temperatures/high charging rates leads to more irreversible capacity losses. This facile method with rational scientific principles can provide inspiration for exploring the safe boundaries of Li‐ion batteries.
Plasmonic Bullseye Nanocavities for Broadband Light Localization and Multi‐Wavelength SERS
Authors: Dixon Katelyn , Hasham Minhal , Shayegannia Moein , Matsuura Naomi , Wilson Mark W.B. , Kherani Nazir P. 
Published: July 2023

AbstractPlasmonic nanostructures capable of broadband light trapping and field enhancement have promising applications in a wide range of fields. This study presents a platform for broadband, polarization‐independent field enhancement in the visible regime through the use of width‐graded nanocavities in a bullseye configuration. The fabrication procedure utilizes electron beam lithography (EBL) to achieve fine control over the nanocavity geometry and template stripping to enable rapid and low‐cost production. The utility of these devices as substrates for multi‐wavelength surface enhanced Raman spectroscopy (SERS) is demonstrated through molecular detection in a 10 μM solution at two excitation wavelengths. The impact of bullseye geometry on both the broadband spectral response and multi‐wavelength SERS performance is examined. The measured SERS enhancement factor (EF) is shown to depend primarily on the plasmonically active surface area of the device, regardless of the local electromagnetic field strength within the nanocavities. These results highlight not only the utility of the width‐graded bullseye as a broadband platform for SERS and other applications but also provide design guidelines to optimize the enhancement factor and broadband performance of similar devices.
Generalized Terahertz Perfect Vortices with Transmutable Intensity Profiles Based on Spin‐Decoupled Geometric Metasurfaces
Authors: Sun Bowen , Zang Xiaofei , Lu Binbin , Chi Haoxiang , Zhou Yiwen , Zhu Yiming , Zhuang Songlin 
Published: July 2023

AbstractPerfect vortex beams (PVBs) possessing orbital angular momentum (OAM) and constant intensity profile enable practical applications in information encoding and transmission due to an unbounded number of orthogonal OAM channels and fixed annular intensity distributions. Geometric metasurfaces, which are 2D counterparts of metamaterials, have provided an ultra‐compact platform to flexibly design perfect vortex beams in a single flat device. However, the previous reported PVBs based on geometric metasurfaces are limited to ring‐shaped intensity profiles and intrinsic spin‐coupling between two orthogonal spin‐components. Here, spin‐decoupled geometric metasurfaces encoding with two‐step coordinate transformations are proposed to generate helicity‐independent PVBs with transmutable intensity profiles. By tailoring local phase gradient along the azimuthal direction, spin‐independent and polarization‐rotated terahertz (THz) PVBs with CN‐fold rotationally symmetric intensity profiles have been theoretically designed and experimentally demonstrated. Furthermore, THz PVBs with arbitrary intensity profiles have also been realized. The unique approach for simultaneously manipulating the spiral phase, focusing phase, as well as intensity profiles will open a new avenue to develop multifunctional integrated devices and systems, which enables potential applications in information processing and optical communication.
Advancements in Airborne Viral Nucleic Acid Detection with Wearable Devices
Authors: Godin Ryan , Hejazi Sepehr , Reuel Nigel F. 
Published: July 2023

AbstractWearable health sensors for an expanding range of physiological parameters have experienced rapid development in recent years and are poised to disrupt the way healthcare is tracked and administered. The monitoring of environmental contaminants with wearable technologies is an additional layer of personal and public healthcare and is also receiving increased focus. Wearable sensors that detect exposure to airborne viruses can alert wearers of viral exposure and prompt proactive testing and minimization of viral spread, benefitting their own health and decreasing community risk. With the high levels of asymptomatic spread of Coronavirus Disease 2019 (COVID‐19) observed during the pandemic, such devices can dramatically enhance the pandemic response capabilities in the future. To facilitate advancements in this area, this review summarizes recent research on airborne viral detection using wearable sensing devices, as well as technologies suitable for wearables. Since the low concentration of viral particles in the air poses significant challenges to detection, methods for airborne viral particle collection and viral sensing are discussed in detail. A special focus is placed on nucleic acid‐based viral sensing mechanisms due to their enhanced ability to discriminate between viral subtypes. Important considerations for integrating airborne viral collection and sensing on a single wearable device are also discussed.
A Binder‐Free and Flexible VOPO4/CNT Film as Cathode for Aqueous Rechargeable Zn‐Metal Battery
Authors: Dilwale Swati , Babu Athira , Puthiyaveetil Priyanka Pandinhare , Kurian Maria , Ghosh Meena , Kurungot Sreekumar 
Published: July 2023

AbstractAqueous rechargeable Zn‐metal batteries (AZMBs) are promising energy storage aids due to their inherent safety, low cost, and competent performance, with prospects in stationary and portable applications. In this regard, one of the critical requirements is developing electrodes that can adapt to mechanical deformation without compromising the charge storage performance. The current work demonstrates the development of a binder‐free and mechanically flexible composite cathode film (VP/fCNT‐F, where ‘F’ stands for the film) based on VOPO4 (VP) and functionalized carbon nanotubes (fCNTs). The VP/fCNT‐F film processing involves simple vacuum filtration of the composite obtained from the in‐situ reaction of the fCNTs and the VP precursor in an aqueous medium. The functionalization of carbon nanotube (CNT) is important for the homogenous dispersion of VP and fCNT. The VP/fCNT‐F electrode is used as a monolithic electrode in AZMB cells in combination with both liquid and quasi‐solid‐state gel polymer electrolytes. Besides, the utility of the VP/fCNT‐F electrode in a flexible battery configuration is also demonstrated. Interestingly, in both the coin‐cell and flexible configurations, the VP/fCNT‐F electrode delivers a comparable discharge capacity of 90 and 78 mAh g−1, respectively (at 0.1 A g−1), validating the advantage of the binder‐free VP/fCNT‐F electrode for AZMBs.
MTA1, a Novel ATP Synthase Complex Modulator, Enhances Colon Cancer Liver Metastasis by Driving Mitochondrial Metabolism Reprogramming
Authors: Wang Ting , Sun Fangzhou , Li Chunxiao , Nan Peng , Song Yan , Wan Xuhao , Mo Hongnan , Wang Jinsong , Zhou Yantong , Guo Yuzheng , Helali Aya Ei , Xu Dongkui , Zhan Qimin , Ma Fei , Qian Haili 
Published: July 2023

AbstractLiver metastasis is the most fatal event of colon cancer patients. Warburg effect has been long challenged by the fact of upregulated oxidative phosphorylation (OXPHOS), while its mechanism remains unclear. Here, metastasis‐associated antigen 1 (MTA1) is identified as a newly identified adenosine triphosphate (ATP) synthase modulator by interacting with ATP synthase F1 subunit alpha (ATP5A), facilitates colon cancer liver metastasis by driving mitochondrial bioenergetic metabolism reprogramming, enhancing OXPHOS; therefore, modulating ATP synthase activity and downstream mTOR pathways. High‐throughput screening of an anticancer drug shows MTA1 knockout increases the sensitivity of colon cancer to mitochondrial bioenergetic metabolism‐targeted drugs and mTOR inhibitors. Inhibiting ATP5A enhances the sensitivity of liver‐metastasized colon cancer to sirolimus in an MTA1‐dependent manner. The therapeutic effects are verified in xenograft models and clinical cases. This research identifies a new modulator of mitochondrial bioenergetic reprogramming in cancer metastasis and reveals a new mechanism on upregulating mitochondrial OXPHOS as the reversal of Warburg effect in cancer metastasis is orchestrated.
Metal‐, Oxidant‐, and Additive‐Free Sulfenylation of Imidazo[1,2‐a]pyridines Using Sulfenamides and an I2 Catalyst
Authors: Qiao Huijie , Zhao Kun , Zhu Xilin , Xu Xiaoxu , Wang Chunyang , Zhong Lulu , Wang Shixing , Yang Liting , Yang Dehong , Liu Guoqun , Lin Chunlei , Jiao Mingli 
Published: July 2023

AbstractA novel sulfenylation reagent (sulfenamide) was applied to establish a simple and efficient process to convert C−H bond in imidazo[1,2‐a]pyridine to C−S bond. This process only requires sulfenamides as the sulfenylation reagent and I2 as an inexpensive and readily available catalyst, without using metal catalysts, oxidants, additives, or even light radiation. The proposed reaction features excellent reactivity, substrate compatibility, and regioselectivity.
Fabrication of Chitosan‐β‐cyclodextrin‐Fe nanofibers for the adsorption of As‐III from aqueous solution using a lab‐scale filtration system
Authors: Jamali Ahmed Ali , Mahar Faraz Khan , Hussain Nadir , Khatri Muzamil , Ullah Azeem , Ahmed Farooq , Khatri Zeeshan , Kim Ick Soo 
Published: July 2023

AbstractArsenate species are hazardous, toxic, and carcinogenic, they pose a significant risk to human health. In this finding, we have fabricated the Chitosan, β‐cyclodextrin and Fe2O3 (CS‐βCD‐Fe2O3) composite nanofibers through electrospinning for arsenic (As‐III) adsorption in a lab‐scale designed continuous filtration system. The SEM images have shown the bead free morphology of the prepared nanofibers and chemical composition was characterized by Fourier transforms infrared (FTIR) spectroscopy. The experimental data supported monolayer adsorptions by having a good fit to the Langmuir model. Further, kinetic studies have been conducted to illustrate the adsorption of As‐III onto CS‐βCD‐Fe2O3. The CS‐βCD‐Fe2O3 nanofibers at neutral pH have shown 83% adsorption efficiency of As‐III in the batch experiments and 72% in continuous filtration system with a flow rate of 660 mL/h. Additionally, the reusability of the nanofibers was performed, and 60% adsorption efficiency was achieved up to the 5th cycle for batch adsorption. Our prepared composite CS‐βCD‐Fe2O3 nanofibers could be used in both batch adsorption and continuous filtration system for removal of As‐III from aqueous solution.
A facile method to fabricate thermally stable methacrylate‐terminated oligo(2,6‐dimethyl‐1,4‐phenylene oxide)/benzoxazine thermosetting resins with low dielectric constants and losses at 10 GHz
Authors: Zeng Ming , Tan Dengru , Feng Zijian , Luo Haoyu , Lu Xiang , Zhou Yang , Shen Yufang , Liu Faxi , Xu Qingyu 
Published: July 2023

AbstractPoly(2,6‐dimethyl‐1,4‐phenylene oxide) (PPO) as a kind of low dielectric polymer has been applied in telecommunications. However, developing PPO based thermosetting resins with good comprehensive properties is highly challenging. Herein, an interpenetrating polymer network (IPN) design strategy for the preparation of methacrylate‐terminated oligo(2,6‐dimethyl‐1,4‐phenylene oxide) (SA9000) based thermosetting resins is presented. Two series of prepolymers are prepared by blending bisphenol A/furfurylamine benzoxazine (B‐f) or bisphenol A/aniline benzoxazine (B‐a) with SA9000. Then the IPN films are fabricated by the programmed temperature rising method with simultaneous polymerization reactions of both SA9000 and benzoxazines. Owing to the intermolecular interactions between SA9000 and benzoxazines, the polymerization peak temperatures of all prepolymers are lower than those of SA9000 and benzoxazines. In comparison with B‐a based films, B‐f/SA9000 films display better miscibility and higher thermal resistances over the entire composition range, due to the strengthened hydrogen bonding and higher cross‐linking density resulting from the presence of furan ring of B‐f. Specifically, B‐f/SA9000 films possess the advantages of low dielectric constants (2.296–2.475) and low‐loss grade dielectric losses (0.00550–0.00683) at 10 GHz. The current work provides a simple and effective path for the fabrication of high‐performance thermosetting PPO resins based on benzoxazine chemistry and IPN structure design.