bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Depression and Anxiety in Syrian Patients with Ankylosing Spondylitis: Associations with Disease-Related Factors, Fatigue, Quality of Life, and Sleep Disturbance - A Cross-Sectional Study
Authors: Safiah Mhd Homam , Ashabi Khaled Kalalib Al , Haj-Abow Tasnim , Alchallah Mhd Obai , Khalayli Naram , Kudsi Maysoun 
Published: September 2023

Abstract
Background
AS Patients are a vulnerable group to mood disorders due to the high burden of their disease and its impact on physical function and quality of life. Identifying risk factors for depression and anxiety is essential for at-risk groups to better outcomes. This study aims to assess the prevalence of depression and anxiety among Syrian AS patients and identify predictive factors.
Methods
This cross-sectional study was conducted using convenience sampling at the biological treatment unit of the rheumatology department in Damascus Hospital. Data were collected from face-to-face interviews with patients using validated structural questionnaires which included socio-demographics, disease characteristics variables, and different measures in order to assess disease activity (ASDAS, BASDAI), physical function and general health (BASFI, BASG), fatigue (FACIT Fatigue Scale), quality of life (ASQoL), depression (PHQ-9), anxiety (GAD-7), and sleep disturbance (JSS). A multiple linear regression model was used to investigate potentially predictive factors for depression and anxiety.
Results
Out of 103 patients, the majority were male 82 (79.6%), 40 (38.8%) quitted working due to disease, and 25 (24.3%) had a positive history of both depression and anxiety. 51 (49.5%) of patients showed clinically significant depression while clinically significant anxiety was identified by 38 (36.9%) of patients. Contextual and disease-related factors associated with depression and anxiety were quitting work due to disease, hip pain, and a positive history of mental distress. Disease activity scores were associated with both depression and anxiety but with low explanatory power. Significant association with relatively high explanatory power demonstrated between both depression and anxiety with poor quality of life, sever fatigue, and high frequency of sleep disturbance.
Conclusion
This study demonstrates high levels of depression and anxiety among Syrian AS patients, along with a high frequency of fatigue and sleep disturbance. Poor Quality of life, sever fatigue, and high frequency sleep disturbance are considered major predictive factors for depression and anxiety. Healthcare providers should pay more attention to depressive and anxiety symptoms in the course of AS patient management.
Genome-wide identification of the cation/proton antiporter (CPA) gene family and functional characterization of the key member BnaA05.NHX2 in allotetraploid rapeseed
Authors: Yue Cai-peng , Han Liao , Sun Si-si , Chen Jun-fan , Feng Ying-na , Huang Jing-yong , Zhou Ting , Hua Ying-peng 
Published: September 2023

Abstract
Rapeseed (Brassica napus L.) is susceptible to nutrient stresses during growth and development. So far, the CPA (cation proton antiporter) family genes have not been identified in B. napus and their biological functions are still unclear. Integrated analyses were conducted to identify the molecular characteristics of rapeseed CPAs and their responses to nutrient stresses. Through bioinformatics analysis, 117 BnaCPAs were identified at the genome-wide level, and they were divided into three subfamilies: Na+/H+ antiporter (NHX), K+ efflux antiporter (KEA), and cation/H+ antiporter (CHX). Transcriptomic profiling results showed that some BnaCPAs had various expression levels under different nutrient stresses especially under salt stress. Most members of the BnaNHX family showed a tendency of expression under different nutrient stress. The BnaNHX subfamily may be an important member of the BnaCPA family in regulating nutrient stress, especially in salt stress. We found that the salt tolerance of the transgenic overexpressed line constructed with BnaA05.NHX2 was significantly higher than that of the wild species Westar. Subcellular localization showed that BnaA05.NHX2 was localized on the tonoplast, and TEM combined with X-ray energy spectrum analysis revealed that the vacuolar Na+ concentrations of the BnaA05.NHX2-overexpressing rapeseed plants were significantly higher than those of wild type. According to our results, we provide insights into the complexity of the BnaCPA gene family and a valuable resource to explore the potential functions of BnaCPA genes in Brassica napus.
Chemical Composition, Allelopathic Potential, and Antimicrobial and Anticholinesterase Activity of Citrus sinensis (L.) Peel Oil
Authors: Silva Vítor Hugo Neves da , Trindade Ívina Thayná Miranda , Vicente Mayanna Emília Tenório , de Souza Geovania Santos , Maia Paulo José Sousa , Ávila Maiara de Souza Nunes , Silva Ingrid Reis da , de Lima Bruna Ribeiro , Carmo Dominique Fernandes de Moura do 
Published: September 2023

Abstract
Citrus sinensis is renowned for its notable biological effects. This research aimed to characterize the chemical composition of oil derived from the peel of Citrus sinensis (L.), referred to as CsPO, and to assess its antimicrobial efficacy against strains of Enterococcus faecalis (ATCC29212), Escherichia coli (ATCC25922), Candida albicans (ATCC10231), and Mycobacterium smegmatis (ATCC14468). Additionally, the investigation sought to analyze its impact on the growth of butter bean (Phaseolus lunatus) radicles, evaluate its inhibitory effects on acetylcholinesterase enzyme (AChE) both in vitro and in silico through molecular docking simulations, and determine its potential phytotoxicity. The analysis of the CsPO composition using gas chromatography coupled with mass spectrometry (GC-MS) identified thirty-three (33) monoterpene and sesquiterpene compounds, e.g., β-citronelene (7.33%), β-pinene (9.63%), car-3-en-2-one (8.43%), eugenol (4.24%), limonene-10-ol (8.26%), α-humulene (10.52%), α-neo-clovene (4.83%), and β-acoradiene (12.47%). CsPO demonstrated varying levels of antimicrobial activity, ranging from low (+) to moderate (++). In the allelopathy assay, one of the treatments exhibited alterations in radicular growth and germination rate of butter bean seeds. The in vitro anticholinesterase assay revealed an inhibitory concentration (IC50) of 72 µg/mL. These findings were corroborated by the in silico anticholinesterase assay, highlighting the potential of β-citronelene, limonene, β-acoradiene, and α-humulene to inhibit acetylcholinesterase. The in silico assay yielded binding energy values between -6.2 and -9.6 kcal/mol, closely resembling those of the galantamine inhibitor (-9.8 kcal/mol, RMSD 0.3678 Å). This study underscores the significant inhibitory activity of CsPO against AChE, suggesting its potential use in treating conditions like Alzheimer’s disease and other relevant ailments. Furthermore, this study aims to enhance the scientific understanding of this essential oil, thus contributing to its potential applications in agriculture and medicine.
Gender Marginalization and Entrepreneurial Motivation in the Global South
Authors: Onoshakpor Chioma , James Imaobong , Ibukun Tolulope , Irene Bridget 
Published: September 2023

Abstract
Purpose
This article sets out to the issues of gender marginalisation and entrepreneurial motivation are increasingly gaining interest in management, mainly to address social and gender exclusion. This paper explores the perceived differences in the motivating factors for women and men in choosing entrepreneurship as a career in a global south economy (Nigeria). This paper explores the perceived differences in the motivating factors for women and men in choosing entrepreneurship as a career in a global south economy (Nigeria). The study examines the role of patriarchy as it is perceived in Nigerian society, and how this might impact on the role of choosing entrepreneurship. These driving forces for entrepreneurship are typically divided into push and pull aspects. The push/pull theory is used to explore gender marginalisation, experienced by women in Nigeria.
Design/methodology/approach
The primary data were collected from semi-structured interviews with 14 males and 16 female entrepreneurs in hospitality and real estate sector in Nigeria. This data was analysed inductively and intuitively using an adapted form of grounded theory analysis. We used this data to develop a robust understanding of different factors that motivate men and women to choose entrepreneurship within Nigerian society.
Findings
Findings demonstrate that while supportive macro environment may be apparent, the entrepreneurial process is characterised, by deep set gendered constructions which policy alone may struggle to change. This is even more apparent due to the various levels of intersecting factors, in this case gender, class and religion.
Originality
This work is set in the sub-Saharan context of Nigeria, the findings illuminate a complex web of forces and how they contribute to a multi-faceted motivation for entrepreneurship.
A Comprehensive Review of Surgical Interventions for Advanced Lymphatic Filariasis: Current Approaches and Outcomes
Authors: Ali Anam Sayed Mushir , Kapil Challa Venkata Sai , Quadri Ahmed Alam , Chowdary Kalyani , Navya A. , Menezes Thanusha , Kathal Ritik , Siddiqua Ayesha 
Published: September 2023

Abstract
Lymphatic Filariasis (LF) is a debilitating disease especially in the advanced stages when the quality of life of the patient is grossly affected due to the associated deformities in the limbs and the urogenital system. In these advanced stages, medical management is seldom effective in improving the deformity and hence surgical management comes into play. Various surgical and micro-surgical techniques are brought into play with varying degrees of success. These range from excisional procedures and lymphatic shunts and anastomosis to hydrocelectomy for bancroftian filariasis. However, definitive studies are lacking on the subject. Therefore, we have investigated all these various techniques across the existing literature on the topic and presented our findings. It was concluded that surgical techniques when applied to advanced grades of lymphatic filariasis, leads to improvement in disfigurement and improved quality of life in the patients. There is a need to develop surgical procedures and medical advancement for optimal outcome of this disease therapeutics until then shunt followed by reduction surgery with skin graft is the most reliable option.
Rwanda’s pathway to net zero empowering smallholder farmers and forest restoration
Authors: Mugabowindekwe Maurice , Brandt Martin , Mukuralinda Athanase , Ciais Philippe , Reiner Florian , Kariryaa Ankit , Igel Christian , Chave Jerome , Mertz Ole , Hiernaux Pierre , Tong Xiaoye , Rwanyiziri Gaspard , Gominski Dimitri , Li Sizhuo , Liu Siyu , Gasangwa Ivan , Hategekimana Yves , Ndoli Alain , Nduwamungu Jean , Saatchi Sassan , Fensholt Rasmus 
Published: September 2023

Abstract
Landscape restoration initiatives are mainly focusing on forest regeneration and agroforestry especially in the Global South. However, due to a lack of monitoring tools, the carbon balance of restoration efforts remains poorly quantified. Here, we use satellite images from 2008 and 2019 to calculate carbon stocks for individual trees in Rwanda, a country which has been actively engaged in restoration activities over the past decade. We show that small-holder farmers on average planted about 3 trees per farm during 2008–2019, contributing about 50.4 million new trees at the national scale. The overall C sink of the new farmland trees was 0.13 Mg C ha− 1 yr− 1, which is 6 times lower than gains observed from restoration of degraded forests (0.76 Mg C ha− 1 yr− 1). If national greenhouse gas emissions remain at the level of 2019, agroforestry (~ 61% of national area coverage) and continued restoration of degraded natural forests (~ 0.5% of national area coverage) have the potential to offset about 80% of the national emissions before 2050. Our work monitors and quantifies progress and impact of landscape restoration projects and outlines a pathway to engage smallholder farmers with a limited number of on-farm trees into the expanding carbon market.
Assessment of blood microRNA expression patterns by predictive classification algorithms can diagnose myxomatous mitral valve disease in dogs
Authors: Palarea-Albaladejo Javier , Bode Elizabeth. F. , Partington Catheryn , Basili Mattia , Mederska Elzbieta , Hodgkiss-Geere Hannah , Capewell Paul , Chauché Caroline , Coultous Robert M , Hanks Eve , Dukes-McEwan Joanna 
Published: September 2023

Abstract

Background: Myxomatous Mitral Valve Disease (MMVD) is a commonly presenting and progressive cardiac pathology in dogs, and early medical intervention can delay progression. Current cardiac biomarkers can be useful in advanced clinical MMVD cases, but are unreliable in pre-clinical disease.Objectives:Assessment of canine serum and plasma expression profiles of 15 miRNA markers as a method to accurately discriminate MMVD patients from healthy controls. Additionally, an assessment of the same method to discriminate pre-clinical (stage B1/B2) from clinical (stage C/D) MMVD patients.Animals:Client-owned dogs (n = 123) were recruited. Following sample exclusions (n=26), healthy controls (n=50) and MMVD cases (n=47) were analyzedMethods:Multicenter, cross-sectional, retrospective investigation. MicroRNA expression profiles were compared between dogs, and the performance of predictive modelling to distinguish healthy controls from MMVD patients, and pre-clinical from clinical MMVD patients was evaluated.Results:Analysis of miRNA expression patterns by predictive classification algorithms could differentiate healthy controls from dogs with MMVD (sensitivity 0.85; specificity 0.82; accuracy; 0.83). Discrimination of pre-clinical (n=29) from clinical (n=18) MMVD cases resulted in promising results (sensitivity 0.61; specificity 0.79; accuracy 0.73). The method also compared advantageously to current biomarkers in a limited population.Conclusions and clinical importance:The analysis of miRNA expression profiles by probabilistic predictive classification algorithms provides a useful diagnostic tool to distinguish healthy controls from MMVD cases (stage B1 to D). Discrimination between pre-clinical and clinical MMVD cases by the same method yielded promising results, which could be further enhanced with an increased study population.
Role of Levatorplasty in Management of Rectal Prolapse in Patients with Wide Pelvic Hiatus
Authors: Shafik Ali Ahmed , El-barmelgi Mohamed Yehia , Mohamed Osama Refaei , Mohamed Mohamed Tamer , Badie Shady Fathy , Shafik Ali Ismail Ahmed 
Published: September 2023

Abstract
Purpose
Rectal prolapse (RP) is a debilitating condition associated with symptoms such as fecal incontinence, obstructed defecation, incomplete rectal evacuation, and significant discomfort. Recent evidence highlights the strong correlation between prolapse development and the size of the pelvic hiatus (GH). Surgical studies have suggested a potential link between an enlarged pelvic hiatus and prolapse recurrence. This study aims to evaluate recurrence rates in patients with rectal prolapse characterized by a wide pelvic hiatus who underwent surgical management.
Methods
In this prospective cohort study, 60 patients with rectal prolapse and a wide pelvic hiatus were divided into two groups, each comprising 30 patients. One group underwent rectal prolapse repair, while the other group underwent rectal prolapse repair with levatorplasty.
Results
The levatorplasty group exhibited notable improvements in Wexner scores and lower recurrence rates compared to the other group. Both groups demonstrated similar outcomes in terms of postoperative pain and dyspareunia.
Conclusion
Rectal prolapse repair combined with levatorplasty represents an effective approach for patients presenting with rectal prolapse and a wide pelvic hiatus. This combination results in improved Wexner scores and reduced recurrence rates, providing valuable insights into the management of this challenging condition.
Enhanced Omicron subvariant cross-neutralization efficacy of a SARS-CoV-2 BA.4/5 mRNA vaccine encoding a noncleaved, nonfusogenic spike antigen
Authors: Oh Jong-Won , Seo Han Young , Jung Haewon , Woo Hawon , Jung Hae-Gwang , Cho Hee , Bak Yeonju , Lee Se-Young , Son Yu-Min , Yoon Gone , Hwang Seo-Yeon , Park Inho , Shin Jeon-Soo 
Published: September 2023

Abstract
The rapid emergence of diverse SARS-CoV-2 variants, notably the Omicron variant, poses challenges to vaccine development. Here, we present a noncleaved, nonfusogenic spike (S) protein eliciting robust B- and T-cell immune responses against Omicron BA.5. The antigen incorporates the R685S and R815A mutations, effectively preventing the shedding of the S1 subunit and eliminating fusogenic activity of the resulting S antigen, termed S(SA). Through reverse genetic analysis, we found that the noncleaved form S protein with the R685S mutation enhances ACE2-dependent viral entry in vitro compared to the wild-type S protein, without increasing the virulence of the mutant virus in mice. The mRNA vaccine encoding the Omicron BA.4/5 S(SA) antigen conferred protective immunity in mice following two doses of 1 mg Ψ-UTP- or UTP-incorporated mRNA vaccines. Despite a roughly 6-fold reduction in neutralizing potency, both mRNA vaccines exhibited broad neutralizing efficacy against Omicron subvariants, including the XBB lineage variants XBB.1.5 and XBB.1.16.
Dinamika Feminisme Islam dalam Mendefinisikan Perempuan
Authors: Imamah Fardan Mahmudatul 
Published: September 2023

Perempuan Muslim belum bersepakat tentang bagaimana hubungan antara feminisme dan Islam. Sebagian menerimanya sebagai bentuk upaya cendikiawan Muslim untuk menginterpretasikan kembali teks-teks keagamaan yang memiliki semangat kesetaraan. Di sisi lain, kritik terhadap feminisme yang dinilai membawa nilai-nilai Barat, nilai-nilai kolonial, dan definisi tunggal atas persoalan perempuan menyebabkan keraguan untuk menyebut upaya kesetaraan dalam Islam sebagai feminisme Islam. Artikel ilmiah ini mencoba untuk meninjau hubungan feminisme dan Islam dari sudut pandang filosofis dalam mendefinisikan perempuan, melalui studi tentang the self, the subject dan makna kesetaraan. Apakah terdapat persamaan dan perbedaan antara feminisme dan Islam dalam mendefinisikan ketiga konsep tersebut. Kajian ini dimulai dari filsafat feminisme melalui teori eksistensialisme Simone De Beauvoir, lahirnya Feminisme Islam, reinterpretasi teks keagamaan, dan dinamika subjektivitas dalam mendefinisikan kebebasan. Hasilnya, perspektif Feminisme dan Islam tidak tunggal. Baik Feminisme dan Islam sepakat atas perempuan sebagai diri dan subjek yang setara antara laki-laki dan perempuan. Namun, terjadi perbedaan tentang bagaimana kesetaraan tersebut didefinisikan khususnya hak-hak dan kewajiban.
Fenomena Kidfluencer dalam Beretika Media Sosial
Authors: Astuti Irawati Diah 
Published: September 2023

Media sosial saat ini menjadi bagian kehidupan yang sulit dipisahkan dari masyarakat. Bahkan, media sosial juga menjadi lahan bagi sebagian orang untuk mengais rupiah yang dipergunakan untuk berbagai kebutuhan hidup. Tak hanya orang dewasa, anak-anak juga turut hadir di media sosial sebagai objek untuk menghasilkan uang. Padahal, penggunaan media sosial dibatasi oleh aturan usia untuk menghindari berbagai hal yang bisa membahayakan anak di masa depan. Namun, orang-orang dewasa, yang umumnya merupakan orang tua si anak itu sendiri, melegitimasi terjunnya anak-anak ke media sosial demi berbagai alasan, salah satunya adalah popularitas dan keuntungan finansial. Penelitian ini menggunakan paradigma konstruktivis dengan pendekatan kualitatif. Strategi penelitian yang digunakan adalah studi pustaka dengan metode pengumpulan data berupa mencari literatur ilmiah yang sesuai dengan tema serta mengobservasi media sosial milik beberapa kidfluencer. Dalam artikel ini, penulis membahas fenomena kidfluencer di media sosial dari perspektif etika. Apakah kehadiran anak-anak sebagai selebriti media sosial sesuai dengan etika? Bagaimana seharusnya peran dan tanggung jawab orang tua dilihat dari perspektif etika? Hasilnya menunjukkan bahwa tindakan orang tua yang membagikan informasi tentang anaknya di media sosial bertentangan dengan etika. Sebab, membagikan konten anak di media sosial akan melucuti sisi humanitas orang tua terutama dari sisi etika.
Pengembangan Sistem Layanan Administrasi Kependudukan Desa Papasan dengan QR Code sebagai Validasi Dokumen
Authors: Wibowo Nur Cahyo Hendro , Khaq Albadru Muh Izul , Nur'aini Siti 
Published: September 2023

Papasan Village is located in the Bangsri sub-district, Jepara district. The process of managing mail services in a day serves 20 submissions of letters. This mail service process is still done manually so it takes a relatively long time. Another problem is the potential for document falsification because administrative data reports are not recorded properly, so in this study a population administration service system was developed that utilizes the Quick Response Code (QR Code). System development is carried out using the waterfall method. The system design stage is carried out using Data Flow Diagrams, while the database design is carried out by compiling a Physical Data Model. The QR Code on the letter is scanned through the system to determine the authenticity of the letter. System testing involved 30 respondents consisting of village heads and village residents. The first test using a black box results that the system can run if the data entered is appropriate and the data is not empty. The second test uses the User Acceptance Test (UAT), the total percentage results are 88% or the system is in the very good category. Desa Papasan terletak di kecamatan Bangsri, kabupaten Jepara. Proses pelayanan pengurusan surat dalam sehari melayani 20 pengajuan surat. Proses pelayanan surat ini masih dilakukan secara manual sehingga membutuhkan waktu yang relatif lama. Permasalahan lainnya adalah adanya potensi pemalsuan dokumen karena laporan data administrasi tidak tercatat dengan baik, maka dalam penelitian ini dikembangkan sistem pelayanan administrasi kependudukan yang memanfaatkan Quick Response Code (QR Code). Pengembangan sistem dilakukan dengan menggunakan metode waterfall. Tahap perancangan sistem dilakukan dengan menggunakan Data Flow Diagram, sedangkan perancangan basis data dilakukan dengan menyusun Model Data Fisik. QR Code pada surat dipindai melalui sistem untuk mengetahui keaslian surat. Pengujian sistem melibatkan 30 responden terdiri dari kepala desa dan warga desa. Pengujian pertama menggunakan black box hasilnya sistem dapat berjalan jika data yang dimasukkan sesuai dan data tidak kosong.
Chatbot Telegram Menggunakan Natural Language Processing
Authors: Furqan Mhd , Sriani Sriani , Shidqi Muhammad Naufal 
Published: September 2023

Media sosial dapat membantu dalam kehidupan sehari-hari untuk berkomunikasi dan mengobrol tanpa batas jarak. Poltekpar memiliki website yang menyediakan informasi tentang tes masuk universitas dan Frequently Ask Question (FAQ) yang bertujuan membantu mahasiswa baru menemukan informasi terkait pendaftaran di Poltekpar. Untuk meningkatkan pelayanan publik, Poltekpar harus memberikan pelayanan yang terbaik pada calon mahasiswa. Pelayanan yang sebelumnya menggunakan FAQ memiliki kendala tidak dapat menjawab secara cepat, sehingga dinilai kurang efisien, maka akan lebih mudah dengan adanya Chatbot yang dapat menjawab pertanyaan secara realtime. Metode penelitian yang digunakan merupakan System Development Life Cycle (SDLC) Waterfall yang memiliki empat tahap yaitu analysis, design, coding dan testing dan menggunakan teknik pengujian aplikasi User Acceptance Testing (UAT). Dalam penelitian ini melakukan proses pembuatan sistem dengan menggunakan metode Natural Language Processing (NLP) yang diterapkan pada sistem yang dibangun dengan Telegram Messenger dan bahasa pemrograman Python. Hasil Chatbot yang diuji mendapat nilai persentase sebesar 94%. Hasil ini menunjukkan sistem Chatbot sangat layak dan efektif dalam membantu mahasiswa memperoleh informasi yang dibutuhkan.