bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fusion of Heterocyclic Aromatic Hydrocarbons With Multiple Resonance: Balancing Spectral Redshifts and Broadening
Authors: Jin Qian , Du Mingxu , Zhang Yuewei , Duan Lian 
Published: January 2025

AbstractEfforts to fabricate ideal narrowband, long‐wavelength (>520 nm) multiple resonance (MR) emitters are often hampered by the mutual obstacles of effective spectral redshift and maintaining a small full width at half maximum (FWHM). This review focuses on a sophisticated molecular design methodology called “fusing heterocyclic aromatic hydrocarbons (HAHs) with MR” to overcome the aforementioned challenges. Here, HAH serves as a rigid structural fragment with a modest reorganization energy, which mainly plays the role of reducing ground‐excited state structural displacement and spectral redshift, while the MR fragment mainly plays the role of restricting low‐frequency vibrational coupling and narrowband emission. The synergy of these two advantages theoretically allows the significant redshift of the emission peak while further narrowing the spectrum. Utilizing the ingeniously designed emitters, the corresponding MR devices can achieve superior external quantum efficiencies of over 20% while maintaining remarkably small FWHMs of <25 nm in the green to red regions. These discoveries will spur the development of narrowband, full‐color, high‐efficiency MR emitters and usher in a transformative shift in the organic light‐emitting diode industry.
V‐/O‐Doping to Endow Ag2S‐based Bimetal Oxysulfide with Sulfur Vacancies and Heterovalent States for Rapid Reduction of Organic and Cr(VI) Pollutants in the Dark
Authors: Wu Xinru , Zhang Pengkun , Insua Benjamin Kunkadma , Yang Baoqian , Kuo Dong‐Hau , Lu Dongfang , Mosisa Mengistu Tadesse , Lin Jinguo , Chen Xiaoyun 
Published: January 2025

AbstractA novel AgVOS oxysulfide catalyst for rapid catalytic reduction of toxic organic substances and Cr(VI) under dark is synthesized by a facile method. With the V/O co‐doping, the doped Ag2S catalyst has the effectively regulated electron transfer performance, the hydrazine‐driven V5+‐to‐V4+ reduction to disturb charge equilibrium, and the formed sulfur vacancy balanced by oxygen doping to maintain charge equilibrium. The formed sulfur vacancy acts as the active site for electrophilic nucleophilic reaction, while the orbital hybridization of O2p and S3p stabilizes the valence state of S2−. A suitable ratio of n(V4+/V5+) is regulated during the hydrazine‐driven synthesis to facilitate the electron transfer and enhance the V5+‐to‐V4+ reduction reaction. V/O co‐doped AgVOS‐3 prepared by a suitable hydrazine content exhibits super catalytic reduction performance of organic 4‐NP (4‐nitrophenol), MB (methyl blue), MO (methyl orange), and RhB (Rhodamine B, 20 ppm, 100 mL) dyes, which are completely reduced within 8, 8, 10, and 8 min, respectively. In comparison, Cr6+ (50 ppm, 100 mL) is also completely reduced within 6 min by AgVOS‐3, indicating its good catalytic reduction activity for organic and inorganic mixture pollutants. Furthermore, AgVOS‐3 has good stability after cyclic tests to maintain a reduction efficiency of 96.5%. Therefore, the AgVOS catalyst shows a promising application for industrial wastewater treatment.
ODSEI Chip: An Open 3D Microfluidic Platform for Studying Tumor Spheroid‐Endothelial Interactions
Authors: Ro Jooyoung , Kim Junyoung , Park Juhee , Choi Yongjun , Cho Yoon‐Kyoung 
Published: January 2025

AbstractCurrent in vitro models of 3D tumor spheroids within the microenvironment have emerged as promising tools for understanding tumor progression and potential drug responses. However, creating spheroids with functional vasculature remains challenging in a controlled and high‐throughput manner. Herein, a novel open 3D‐microarray platform is presented for a spheroid‐endothelium interaction (ODSEI) chip, capable of arraying more than 1000 spheroids on top of the vasculature, compartmentalized for single spheroid‐level analysis of drug resistance, and allows for the extraction of specific spheroids for further analysis. As proof of concept, the crosstalk between breast cancer spheroids and vasculature is monitored, validating the roles of endothelial cells in acquired tamoxifen resistance. Cancer spheroids exhibited reduced sensitivity to tamoxifen in the presence of vasculature. Further analysis through single‐cell RNA sequencing of extracted spheroids and protein arrays elucidated gene expression profiles and cytokines associated with acquired tamoxifen resistance, particularly involving the TNF‐α pathway via NF‐κB and mTOR signaling. By targeting the highly expressed cytokines (IL‐8, TIMP1) identified, tamoxifen resistance in cancer spheroid can be effectively reversed. In summary, the ODSEI chip allows to study spheroid and endothelial interaction in various contexts, leading to improved insights into tumor biology and therapeutic strategies.
Visible‐Light‐Driven Fluorescence Turn‐on Photoswitches With Near Quantitative Photocyclization Yield
Authors: Zhai Jiawei , Ai Qi , Li Huaqing , Liu Zugang , Hu Xiaoguang 
Published: January 2025

AbstractPhotoswitchable fluorescent materials have gained significant attention for their potential in advanced information encryption and anti‐counterfeiting applications. However, the common use of UV light to trigger the isomerization processes leads to photobleaching and poor fatigue resistance. Visible‐light‐driven fluorescent photoswitches are highly desirable, but achieving high cyclization yield remains challenging. Herein, it is reported that all visible‐light‐driven turn‐on fluorescence in dimethoxyphenyl functionalized diarylethene isomers. The open‐ring form of o‐DMPB and p‐DMPB exhibits near quantitative conversion yields (up to 94%) under 405 nm visible light, attributed to the strong electron‐donating character. In contrast, the meta isomer m‐DMPB shows limited response to visible light, with a ring‐closing yield of 22%. Furthermore, all photoswitches display good thermal stability, photostability, and fatigue resistance. Notably, o‐DMPB demonstrates promising applications in anti‐counterfeiting, information encryption, and photorewritable patterns. This work provides a valuable strategy for the development of high‐performance fluorescent photoswitches.
Integrated learning‐based estimation and nonlinear predictive control of an ammonia synthesis reactor
Authors: Bagheri Amirsalar , Cabral Thiago Oliveira , Pourkargar Davood B. 
Published: January 2025

AbstractThis paper presents an advanced machine learning‐based framework designed for predictive modeling, state estimation, and feedback control of ammonia synthesis reactor dynamics. A high‐fidelity two‐dimensional multiphysics model is employed to generate a comprehensive dataset that captures variable dynamics under various operational conditions. Surrogate long short‐term memory neural networks are trained to enable real‐time predictions and model‐based control. Additionally, a feedforward neural network is developed to estimate the outlet ammonia concentration and hotspot temperature using spatially distributed temperature readings, thereby addressing the challenges associated with real‐time concentration and maximum temperature measurements. The machine learning‐based predictive modeling and state estimation methods are integrated into a model predictive control architecture to regulate ammonia synthesis. Simulation results demonstrate that the machine learning surrogates accurately represent the nonlinear process dynamics with minimal discrepancy while reducing optimization costs compared to the high‐fidelity model, ensuring adaptability and effective guidance of the reactor to desired set points.
MATES in Manufacturing: A Cluster RCT Evaluation of a Workplace Suicide Prevention Program
Authors: LaMontagne Anthony D. , Lockwood Christopher , Mackinnon Andrew , Henry David , Cox Laura , Hall Neil R. , King Tania L. 
Published: January 2025

ABSTRACTBackgroundThe MATES in Construction suicide prevention program was adapted to the manufacturing sector and evaluated in a pilot of the program.MethodsTen manufacturing worksites were randomly assigned to intervention (5 sites) and wait‐list control (5 sites) conditions in a two‐arm cluster randomized design. 1245 workers responded at baseline (87% response rate) and 648 at final (35% response rate). Literacy of Suicide Scale (LOSS) was assessed as a process outcome, and help‐seeking intentions as the primary outcome (General Help‐Seeking Questionnaire [GHSQ] score). Secondary outcomes included help sought, suicidal thoughts and likelihood of suicide attempt scores, and Kessler‐6 scores. Linear mixed models for repeated measures were used in intention‐to‐treat (ITT) and completer analyses.ResultsAll sites finished the trial, with intervention periods ranging from 8 to 11 months; however, none of the five intervention sites fully implemented the intervention as planned. ITT analyses showed an improvement in LOSS scores within the intervention group (0.49, 95% CI 0.13–0.49), but the mean difference in change between intervention and control included the null (0.34, 95% CI −0.10 to 0.80). The primary outcome of GHSQ scores also improved within the intervention group, but the difference in change included the null (mean difference 1.52, 95% CI −0.69 to 3.74). No secondary outcomes improved relative to control in ITT or completers analyses. Exploratory analysis of disaggregated GHSQ help sources showed greater improvement in mean difference in change for the main MATES message of seeking help from MATES Connectors.ConclusionThe intervention, as implemented, was not effective at achieving the primary or secondary outcomes.Trial RegistrationAustralian and New Zealand Clinical Trial Registry: ACTRN 12622000122752.
Spreading the Word: Communicating Evidence‐Based Guidelines About Turner Syndrome to Patients, Parents, Providers, and Payors
Authors: Lin Angela E. , Kruszka Paul 
Published: January 2025

ABSTRACTGiven the overwhelming volume of medical information, medical guidelines play a key role in informing clinicians and payors and guidelines directly affect how patients, and their families will be treated. In this review, we describe the production cycle of international guidelines for Turner syndrome (TS) and promote the timely and proactive dissemination of these guidelines. We encourage deliberate adoption of an updated standard of care by providers, payors, patients and their families, and professional organizations.
Rapid and Scalable Preparation of High‐Crystalline Carboxyl‐Functionalized Covalent Triazine Frameworks via Friedel‐Crafts Reaction
Authors: Zhang Lei , Sun Tian , Zhang Zhao , Zhang Ziyue , Xu Yuxi 
Published: January 2025

AbstractThe Friedel‐Crafts reaction has been extensively applied to the preparation of various porous organic polymers because of its simple operation and abundant building blocks. However, due to its poor reversibility and excessive random reactive sites, the synthesis of crystalline organic polymers/frameworks by Friedel‐Crafts reaction has never been realized so far. Herein, we develop a molecular confined Friedel‐Crafts reaction strategy to achieve rapid preparation (within only 30 minutes) of highly crystalline covalent triazine frameworks (CTFs) with tailorable functionality for the first time. Theoretical calculations and detailed experiments revealed the critical role of carboxyl groups in aromatic benzene monomer during the CTFs crystallization, which can not only effectively cause a suitable activation barrier for the electrophilic attack of 2,4,6‐trichloro‐1,3,5‐triazine through their electron‐withdrawing properties, but also introduce anchoring effects (molecular confinement effects) to facilitate the ordered polymerization at specific sites in 2D planar direction. Benefiting from the convenient synthetic route and low‐cost raw materials, we could unprecedentedly realize the kilogram‐scale fabrication of carboxyl‐functionalized high‐crystalline CTFs. Moreover, thanks to the hydrophilic and ionizable properties of carboxyl groups, the obtained functionalized CTFs exhibited excellent aqueous dispersibility and superior solution processability.
Critical role for Transglutaminase 2 in scleroderma skin fibrosis and in the development of dermal sclerosis in a mouse model of scleroderma
Authors: Tam Angela Y.Y. , Khan Korsa , Xu Shiwen , Bergin Marianne , Huang Linghong , Arroyo Colon Erik , Cheng Danyi , Verderio Elisabetta AM , Ong Voon , Denton Christopher P , Atkinson John , Johnson Tim S , Abraham David J. 
Published: January 2025

ObjectiveScleroderma is a life‐threatening autoimmune disease characterized by inflammation, tissue remodelling, and fibrosis. This study aimed to investigate the expression and function of transglutaminase 2 (TGM2) in scleroderma skin and experimentally‐induced dermal fibrosis to determine its potential role and therapeutic implications.MethodsWe performed immunohistochemistry on skin sections to assess TGM2 expression and localisation, and protein biochemistry of both SSc‐derived and healthy control dermal fibroblasts to assess TGM2 expression, function and ECM deposition in the presence of a TGM2 and TGFβ neutralizing antibodies and a small molecule inhibitor of the TGFβRI kinase. Mice with a complete deficiency of TGM2 (Tgm2‐/‐) were investigated in the bleomycin‐induced model of skin fibrosis.ResultsTGM2 was found to be widely expressed in both control and scleroderma skin samples, as well as in cultured fibroblasts. Scleroderma fibroblasts exhibited elevated TGM2 expression, which correlated with increased expression of fibrosis markers (collagen type 1, αSMA and CCN2). Inhibition of TGM2 using a neutralizing antibody reduced the expression of key markers of fibrosis. The effects of TGM2 inhibition were similar to those observed with TGFβ neutralization, suggesting a potential cross‐talk between TGM2 and TGFβ signalling. Moreover, TGM2 knock‐out mice showed significantly reduced dermal fibrosis compared to wild‐type mice. In vitro experiments with TGM2‐deleted fibroblasts demonstrated impaired cell migration and collagen matrix contraction, which could be partially restored by exogenous TGFβ.ConclusionTGM2 can regulate several key pro‐fibrotic activities of TGFβ suggesting that attenuating TGM2 function may be of benefit in severe forms of connective tissue disease with skin fibrosis.image
Microwave‐Assisted Cobalt‐Catalyzed Synthesis of Quinazolinones via Acceptorless Dehydrogenative Coupling under Neat Condition
Authors: Pal Adwitiya , Majumdar Adrija , Sau Subham , Thakur Arunabha 
Published: January 2025

AbstractHerein, we present a sustainable and atom‐economical approach for the synthesis of quinazolinones via acceptorless dehydrogenative coupling (ADC) using earth‐abundant Co‐salt, (CoCl2) as the catalyst under neat condition. This method is distinguished by its green credentials, like, solvent‐free, microwave‐assisted heating, cost‐effective, use of renewable alcohols, and generating only H2 and water as byproducts. Remarkably, this protocol achieves quinazolinone synthesis without the need for external ligands, oxidants, or additional additives. Two synthetic pathways were developed: one involving the coupling of alcohols with 2‐aminobenzamide, and the other with N‐phenyl‐substituted 2‐aminobenzamides and its derivative. The scalability of this method, demonstrated through gram‐scale synthesis, highlights its potential for industrial applications. Mechanistic insights were explored through control experiments, intermediate detection by HRMS, and Hammett analysis, shedding light on the plausible reaction pathway.
Robustness analysis for switched cyber‐physical systems via logical networks
Authors: Zhao Guodong , Zhang Wenxin , Li Haitao 
Published: January 2025

AbstractThis paper presents robustness analysis for a kind of switched cyber‐physical systems in view of input‐output dynamical stability. At first, the underly definitions of switched systems and the input–output dynamical stability of switched systems are proposed. Secondly, an algorithm, which is aimed to transform the given switched finite systems into switched logical networks, is constructed and input–output dynamical stability between them is analyzed. Thirdly, with the help of approximate simulation relation, the switched infinite systems are approximated as switched finite systems, and input–output dynamical stability between them is also analyzed. Then, input–output dynamical stability of the given switched cyber‐physical systems is analyzed via the aforementioned results. Finally, an illustrative example is given to verify whether all the results are correct.
Feasibility and acceptability of Body Signal Integration training for Functional Neurological Disorder (FND): A case series
Authors: Panchmatia Krishna , Poliakoff Ellen , Brown Richard J. 
Published: January 2025

AbstractObjectivesFunctional neurological disorder (FND) is a common and often disabling condition, but existing treatments are limited and often do not target relevant underlying mechanisms. This study piloted a manualised intervention package—Body Signal Integration (BSI) training—designed to improve interoception and mind–body integration in individuals with FND. The primary aim was to determine feasibility and acceptability of delivering BSI. A secondary aim was to gather preliminary evidence regarding whether BSI is associated with reductions in FND symptoms and distress.MethodsA case series of BSI was conducted with eight individuals with FND. Baseline, weekly and one‐month follow‐up self‐report measures were completed. Feasibility was assessed by attendance and protocol adherence. Acceptability was evaluated using a self‐report measure. Weekly clinical outcome measures were completed.ResultsSeven of eight participants completed therapy with a total attendance rate of 98%. There were no unanticipated side effects or adverse events during therapy. High ratings on all items on the satisfaction questionnaire indicated treatment acceptability. Improvements in somatic symptoms, interoceptive awareness and quality of life were observed in some, but not all, participants. Five participants reported clinically important improvements in interoceptive awareness.DiscussionThis preliminary study suggests that BSI is feasible and acceptable for use in FND. Clinical outcomes indicate that BSI could improve interoceptive sensibility and reduce experiences of somatic symptoms for some people with FND, but variation in outcomes suggests that the treatment may be suitable for some people more than others. Qualitative process evaluation of the treatment is recommended.
Perspectives of Psychotherapists Regarding Psychedelic Assisted Therapy
Authors: Kinahan Seán , Wilson Elizabeth 
Published: January 2025

ABSTRACTBackgroundThis study explored the perspectives of trainees, recently qualified and experienced psychotherapists regarding psychedelic assisted therapy (PAT).AimsThe aim was to capture meaning, concerns and opportunities of PAT and understand what it means for the field of psychotherapy and to contribute to the growing body of literature on its development and inform subsequent research.Material and MethodsThe study was based on qualitative research capturing the perspectives of a range of counsellors via a questionnaire, two interviews and a focus group comprised of five people, with the dataset being analysed using reflexive thematic analysis (TA; Thematic Analysis—A Practical Guide, Sage, Thousand Oaks, CA, 2022) to capture meaning, experiences and perceptions and to identify descriptive and interpretive themes.ResultsThemes relating to therapeutic relationship, safety, ownership and professionalisation were identified within the dataset.DiscussionThe findings from this study reveal a complex and multi‐layered understanding of PAT, where a range of factors, such as the therapist's experience, the therapeutic relationship, safety concerns and issues of ownership and professionalisation, are all central. The themes demonstrated how counsellors are already aware of, interested in and curious about development in PAT and indicated a sense of inevitability of PAT becoming a professionalised part of the field of psychotherapy.ConclusionThe study concludes that while there are understandable and relevant concerns about safety, there is also a growing body of quality research and recommendations for safe and harm reducing processes and opportunities for psychotherapy bodies to lead the way and ensure the approach of PAT is a professional one underpinned by research, harm reduction, ethical standards and a sensitivity towards its Indigenous roots.
Synthesis, Antibacterial, and Antibiofilm Activities of Imidazo[2,1‐b]Thiazole Chalcone Derivatives: In Vitro and In Silico Studies
Authors: Azzouzi Mohamed , Boutaybi Mohamed El , Majidi El Hassan El , Timinouni Mohammed , Khattabi Lamiae El , Dioukhane Khadim , Fait Sofia , Oussaid Adyl 
Published: January 2025

ABSTRACTIn recent years, imidazothiazole–chalcone conjugates have emerged as notable pharmacophores with potential applications in discovering biologically active compounds. This study focuses on synthesizing novel imidazo[2,1‐b]thiazole chalcone derivatives through a facile and conventional process adhering to several principles of green chemistry, facilitating scalable production. The synthesized compounds underwent comprehensive spectroscopic analysis, including 1H NMR, 13C NMR, LC–MS, and FT‐infrared (IR) techniques. Theoretical FT‐IR and NMR analysis, frontier molecular orbitals (FMOs), and global reactivity descriptors were calculated and interpreted. Furthermore, molecular electrostatic potential (MEP) surface, Mulliken atomic charge, electron localization function (ELF), localized orbital locator (LOL), and quantum theory of atoms in molecules (QTAIM) were analyzed. The newly synthesized compounds were screened in vitro for their antibacterial and antibiofilm activities. In addition, computational docking studies were performed to gain further insights into molecular interactions and found to support the results.
Breaking New Ground: A Seropositive Neuromyelitis Optica (NMOSD) in Ethiopian Patients: A Case Series
Authors: Belete Yegzeru , Kuma Abera , Habtamu Wasyihun , Fulas Munewer , Girma Abdulkerim , Tadesse Sinetibeb , Anegagregn Amanuel 
Published: January 2025

ABSTRACTThis case series highlights the diverse presentations of seropositive neuromyelitis optica spectrum disorder, including the absence of optic neuritis despite anti‐aquaporin 4 antibody positivity. It emphasizes the importance of high index of suspicion, early neurologist referral for improved outcomes, the consequences of delayed referral, and the challenges and treatment potential in low‐income countries with limited resources.
I had a dream
Authors: Perbal Bernard 
Published: January 2025

AbstractExpressing hopes and desires is an essential part of communication, and communication is the major pillar of the Journal of Cell Communication and Signaling. There comes the time of giving the responsibility of leading JCCS to a new editor in chief and I am taking this opportunity to comment on a few recent milestones and future of the journal which I created in 2007, after I had created “Cell Communication and Signaling” 20 years ago (1), one of the first open access journals.