bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Biotechnological Potential of Endophytic Fungi from Acorus calamus: Enzymatic Activity, Antimicrobial Properties, and Siderophore Production
Authors: Parki Prabha , Verma Himani , Rana Babita , Khulbe Kapil 
Published: September 2023

Abstract

The leaves and rhizome of Acorus calamus (Acoraceae) were investigated for the endophytic fungi associated with the plant. Two fungal endophytes were isolated and confirmed as Cladosporium sphaerospermumand Plectosphaerella sp. using molecular techniques. Both species were recorded as new isolates of A. calamus. The isolates were tested for extracellular enzyme production. The Plectosphaerella sp. demonstrated enzymatic activity in maximum instances, whereas C. sphaerospermum displayed positive results for three extracellular enzyme production (pectinase, cellulase, and tyrosinase) activities. The preliminary siderophore production assay was done, and Plectosphaerella sp. was found to have the potential for siderophore production. Both fungal isolates were screened for preliminary antibacterial activity by the agar-well diffusion method against plant and animal pathogens, in which C. sphaerospermumshowed the maximum zone of inhibition against the animal pathogenic Bacillus megaterium (30.67 ± 1.64) while Plectosphaerella sp. against Staphylococcus aureus(16.67 ± 1.20). When tested against plant pathogenic strains, C.sphaerospermum showed the maximum zone of inhibition against Xanthomonas phaseoli (31.50 ± 1.76) and Plectosphaerella sp. against Xanthomonas campestris (15.33 ± 0.88).
Financial conflicts of interest among authors of clinical practice guideline for diabetes mellitus in Japan between 2016 and 2020
Authors: Murayama Anju 
Published: September 2023

Abstract
Aims:
To assess the financial relationships between pharmaceutical companies and authors of the Japanese Clinical Practice Guideline for Diabetes 2019.
Methods:
Retrospective analysis of publicly available pharmaceutical-industry personal payments evaluated size and prevalence of financial relationships between all 27 authors of the CPG and pharmaceutical companies in Japan. Personal payments from pharmaceutical companies to the authors between 2016 and 2020 were extracted from publicly disclosed database and each pharmaceutical company.
Results:
Of all 135 authors of clinical practice guideline for diabetes mellitus developed by the Japan Diabetes Society in 2019, 129 (95.6%) received personal payments from pharmaceutical companies between 2016 and 2020. The total amounts of personal payments were $23,130,423, with a median of $89,955 and an average of $171,336 per author. More than 74.1% (100 authors), 60.7% (82 authors), and 47.4% (64 authors) received more than $10,000, $50,000, and $100,000 personal payments in total over the five years, respectively. The guideline chairpersons of the guideline development and review committees received substantial amounts of personal payments from the companies during the guideline development period.
Conclusion:
Nearly all guideline authors received substantial amounts of personal payments from pharmaceutical companies during the guideline development period and one year after its publication. Nevertheless, the Japan Diabetes Society roughly managed their COIs, and many authors self-declared no financial COIs with pharmaceutical companies even though they received moderate amounts of personal payments. These findings underscore the urgent need for policy interventions to enhance transparency, integrity, and reliability in the development of clinical practice guidelines in Japan.
Мутационный профиль генома нормальных и опухолевых клеток у больного множественной миеломой (клиническое наблюдение)
Authors: Жук А. С. , Кострома И. И. , Степченкова Елена Игоревна , Качкин Д. В. , Белопольская О. Б. , Зотова И. В. , Гарифуллин А. Д. , Волошин С. В. , Грицаев С. В. , Аксенова А. Ю. 
Published: September 2023

This paper is a case report of a patient with newly diagnosed multiple myeloma (MM) who underwent exome sequencing of peripheral blood lymphocytes and CD138+ tumor plasma cells prior to therapy. This patient showed some inherited genetic variants which are associated with underlying risk for MM. This patient’s genotype was reported to have some variants in the DNA repair genes, including inherited mutations in the RFDW3 and TP53 genes. They are involved in the maintenance of genome stability and accumulation rate of somatic mutations, including structural rearrangements and chromosome aberrations. A large number of structural variations
and mutational signature ID6 in the tumor genetic material point to the disruption of DNA damage repair. The tumor cell exome analysis yielded a profile of somatic mutations, also the mutations in the genes previously associated with MM, as well as a functional significance of the detected abnormalities. Somatic mutations also included damaging mutations and highly significant mutations in the other tumor-associated genes, such as ASCC3, TET3, and CHD1, as well as in the antimicrobial peptide-coding genes CAMP and HTN3. With the exception of an extra copy of 1q arm in the tumor plasma cell genome, the patient showed no genetic risk factors associated with poor prognosis of the disease. Based on literature, inherited (ABCB1 mutations) and somatic (trisomy 3) variations detected in the patient’s genetic material can be characterized as positive prognostic factors in MM.
Complex skin care for psoriasis: effective control with modern dermatocosmetic products
Authors: Zhukova O. V. , Artemyeva S. I. 
Published: September 2023

Introduction. Recent decades have witnessed significant progress in the dermatocosmetic industry, driven by increased knowledge of skin physiology, development of new active ingredients and products based on well-studied action mechanisms. Dermatovenerologists actively use dermatocosmetics in inflammatory skin diseases, which include psoriasis. Even in mild forms, psoriatic rashes can be accompanied by itching and flaking. A significant proportion of patients have lesions on exposed skin, and the disease has a severe psychosocial burden. Full and successful control of psoriasis requires the use of adjuvant agents, which can be used alone to maintain remission or as an adjunct to medication, also reducing the negative effects of treatment. The Kertyol P.S.O. Ducray range is represented by products containing active components with anti-inflammatory, antipruritic, keratoregulatory action.Aim. To evaluate the effectiveness of including the Kertyol P.S.O. Ducray range of products in the treatment regimen of patients with psoriasis.Materials and methods. 20 patients with localization of psoriatic rashes on smooth skin and scalp were included in the study. Kertyol P.S.O. Ducray concentrate in combination with calcipotriol was recommended for smooth skin rashes, and daily skin care was corrected; Kertyol P.S.O. Ducray concentrate and regenerating shampoo in combination with calcipotriol/betamethasone dipropionate were recommended for scalp skin.Results. At the 4th week of therapy the average reduction of PASI index in the complex evaluation of clinical manifestations amounted to 89.6%; antipruritic effect was determined by the dynamics of VAS – the average reduction of the index at the 4th week amounted to 90.6%. Dermatologic life quality index (DLQI) decreased by 89.5% at the 4th week of therapy.Conclusion. Kertyol P.S.O. Ducray products can be recommended as an effective adjuvant therapy for smooth skin and scalp psoriasis.
Alterations in <I>IL</I>-17 expression in pediatric patients with psoriatic arthritis
Authors: Chebysheva S. N. , Sobolev V. V. , Geppe N. A. , Soboleva A. G. , Korsunskaya I. M. 
Published: September 2023

Introduction. Psoriatic arthritis is a common inflammatory disease affecting the joints and it is usually accompanied by plaque psoriasis. The pathogenetic link between psoriasis and psoriatic arthritis well reflects the mechanistic hypotheses of disease pathogenesis. Psoriatic arthritis is characterized by chronic inflammation which results in bone erosion and bone loss, as well as new bone formation around the affected joints. The exaggerated inflammatory response leads to enthesitis with the crucial contribution of IL-17 producing T cells and entheseal resident cells, expressing IL-23R. Studying the IL-17 gene expression patterns can help choose a therapy for patients with psoriatic arthritis.Aim. To study alterations in IL-17 gene expression in immune cells of paediatric patients with psoriatic arthritis.Materials and methods. Mono nuclear cells were isolated from the peripheral blood of 45 patients with psoriatic arthritis and 20 healthy controls. The IL-17 gene expression was analysed using a real-time PCR.Results and discussion. Mononuclear cells were isolated from whole peripheral blood for subsequent analysis of IL-17 gene expression by quantitative RT-PCR. The comparative analysis of the expression levels of patients with psoriatic arthritis and healthy volunteers showed that the expression level of IL-17 gene in patients with psoriatic arthritis was 345 times higher than the expression level in healthy volunteers.Conclusion. Patients with psoriatic arthritis are characterized by a very high level of IL-17 gene expression in immune blood cells. The high IL-17 gene expression level confirms its significant role in the inflammatory process in patients with psoriatic arthritis.
Microbial Biomass as a Bioresource of Functional Food Ingredients: A Review
Authors: Serba Elena , Yuraskina Tatyana , Rimareva Liubov , Tadzibova Polina , Sokolova Elena , Volkova Galina 
Published: September 2023

Microbial biomass is a promising source of essential macro- and micronutrients to be used in the food industry, e.g., protein, vitamins, essential amino acids, polysaccharide, etc. This article reviews scientific publications on the properties and composition of microbial biomass as a source of functional ingredients, its biological effectiveness, production methods, and composition.
The review covered research articles published in 2005–2021 and indexed in eLIBRARY.RU, Google Scholar, Scopus, Elsevier, and PubMed. It relied on such general scientific methods as analysis, generalization, and systematization.
Saccharomyces cerevisiae yeast and Aspergillus mycelial fungi appeared to be the most popular research objects. Most studies concentrated on the chitin-glucan-mannan complex of cell walls and protoplasmic biovaluable protein. Others featured the biocatalytic conversion of microbial polymers with the transfer of biologically valuable components into an enzyme-accessible state. Bioactive ingredients of microbial origin could be divided into sorbents, immunomodulators, neurotransmitters, antioxidants, and anticarcinogenics.
Microbial fermentolysates are a potential source of bioactive compounds for functional foods. However, the medical and biological properties of their minor bioactive components remain understudied while fermentolysates can yield new functional products fortified with essential amino acids and low-molecular bioactive peptides.
FENG SHUI SUPERSTITIOUS BELIEF: DOES IT INFLUENCE YOUNG GENERATIONS IN HOUSING PURCHASE INTENTION?
Authors: Hassan Mohammad Mujaheed , Tedong Peter Aning , Haris Fadzilah Asmaul Husna 
Published: September 2023

Superstition is an indispensable part of every ethnic culture in Malaysia. Each race has its own culture and its own superstitions. This is certainly true in the multicultural landscape of Malaysia. Since superstition is part of daily life, it can even have an impact on the housing property market. This article aims to examine the superstitious beliefs in Feng Shui of the young generation’s intention to buy a house. This study focuses on the young generation with the prime working-aged between 25 and 40 years old in the Klang Valley. This study uses quantitative methods. A total of 2,600 questionnaires were distributed, however, only 97% or 2523 questionnaires are valid to proceed for data analysis. In summary, there is a significant correlation between the influences of superstition beliefs on the willingness of a young one to buy a house. Superstition is affecting the decision-making process of the Chinese community.
Gay App Use, Sexuality Traits, and High-Risk Sexual Behaviors Among Men Who Have Sex With Men in China: Mediation Analysis
Authors: Luo Rui , Xie Zhi , Silenzio Vincent M B , Kuang Yun , Luo Dan 
Published: September 2023

Background
Gay geosocial networking apps, also known as “gay apps,” have gained increasing popularity in the men who have sex with men (MSM) community. Certain sexuality traits and gay app use are both associated with high-risk sexual behaviors among MSM. However, little is known about the underlying mechanism of such relationships.

Objective
Based on the uses and gratifications theory, this study aimed to test the mediation effect of gay app use on the relationship between sexuality traits (sexual compulsivity and sexual sensation seeking) and high-risk sexual behaviors (multiple sexual partners and unprotected anal intercourse) among MSM.

Methods
A cross-sectional, multicenter study was conducted in Wuhan and Changsha, China, from August to October 2020. A representative sample of 402 MSM was recruited through respondent-driven sampling. A self-administered web-based structured questionnaire was used to collect data on sociodemographic information, high-risk sexual behaviors, gay app use, sexual compulsivity, and sexual sensation seeking. Path analysis was conducted to assess the mediation effect.

Results
Our study revealed that 67.42% (n=271) of MSM used gay apps for seeking potential sexual partners, with 37.06% (n=149) of them engaging in unprotected anal intercourse, and 45.42% (n=218) of them having multiple sexual partners. Of the participants, 17.16% (n=69) reported significant sexual compulsivity, while 29.10% (n=117) reported significant sexual sensation seeking. Notably, gay app usage partially mediated the relationship between sexual compulsivity and multiple sexual partners but fully mediated the relationship between sexual compulsivity and unprotected anal intercourse. Furthermore, gay app usage partially mediated the relationship between sexual sensation seeking and multiple sexual partners but fully mediated the relationship between sexual sensation seeking and unprotected anal intercourse.

Conclusions
High-risk sexual behaviors are common among MSM. Most MSM rely on gay apps to find sexual partners, which, when combined with higher levels of sexual compulsivity and sexual sensation seeking, can increase the likelihood of engaging in high-risk sexual behaviors. Therefore, interventions aimed at reducing these behaviors among MSM should focus on addressing the use of gay apps, while also considering the influence of their sexuality traits on gay app use.
CRECIMIENTO, DESINFLACIÓN Y DISTRIBUCIÓN: ¿OTRA TRINIDAD IMPOSIBLE?
Authors: Fares Florencia Melisa , Zack Guido , Libman Emiliano 
Published: September 2023

RESUMEN
En este trabajo desarrollamos un modelo teórico que explora los efectos desinflacionarios y distributivos del crecimiento económico. Sin margen para fijar el tipo de cambio nominal y con falta de credibilidad de la autoridad monetaria, el crecimiento puede ser una alternativa para la desinflación si se sostiene con incrementos de la productividad. En condiciones no tan particulares, asociadas al valor que toman las elasticidades empleo-producto e importaciones-producto, no sólo no es necesario resignar crecimiento para reducir la inflación, sino que este permite reducir los costos unitarios de producción por incrementos de productividad. No obstante, esta estrategia basada en el crecimiento trae consigo una mayor desigualdad de ingresos, y si los salarios son muy sensibles al crecimiento del producto podrían ser contraproducentes para la desinflación.

GROWTH, DISINFLATION AND DISTRIBUTION: ANOTHER IMPOSSIBLE TRINITY?
ABSTRACT
This paper builds a theoretical model that seeks to explore the disinflationary and distributional effects of economic growth. With no margin to fix the nominal exchange rate, and with a lack of credibility of the monetary authority, growth can be an alternative to disinflation if it is supported by productivity increases. Under not so particular conditions, associated with the value of employment-output and imports-output elasticities, not only is it not necessary to give up growth to reduce inflation, but it also allows reducing unit production costs through productivity increases. However, this growth-based strategy brings with it greater income inequality, and if wages are very sensitive to output growth it could be counterproductive to disinflation.
From the History of the Basilian Monks in Jēkabpils. Two Letters from the End of the 18th Century from the Former Archive of the Borch Family
Authors: Rączka-Jeziorska Teresa , Jeziorski Paweł A. 
Published: September 2023

The two letters from the end of the 18th century presented here are an interesting source for research into the history of the Basilian mission in eighteenth-century Jēkabpils (in Polish: Jakobsztat). They were written by Basilian monks working in the town and addressed to an unknown person, who, however, must undoubtedly be identified as Michał Jan Borch (in Latvian: Mihaels fon der Borhs), owner of the Varakļāni (in Polish: Warklany) estate in the former Polish Livonia (in Polish: Inflanty Polskie). The addressee of both letters is not accidental. The Basilian monks asked Borch for support of conducted construction works, bearing in mind that it was his ancestor who had funded their mission. Michał Jan Borch did not disappoint the monks, as he fulfilled at least some of the requests addressed to him.
Pretošanās kustība nacionālsociālistiskās Vācijas okupētajā Latvijā (1941–1945). Pētniecības sasniegumi un problēmas
Authors: Neiburgs Uldis 
Published: September 2023

Otrā pasaules kara laikā, kad Latvijas teritoriju pārvaldīja viena okupācijas vara – nacionālsociālistiskās Vācijas –, bet draudēja otras – PSRS – atgriešanās, Latvijas tautas pašnoteikšanās centienus un vēlmi atgūt valstisko neatkarību pauda nacionālā pretošanās kustība, kam piemita dažādas organizētas un individuālas izpausmes. Rakstā kritiski izvērtēti līdzšinējie pētījumi, dokumentu publikācijas un atmiņas par pretošanās kustības aktivitātēm un sniegts vispārīgs pārskats par pretošanās kustību Latvijā nacistiskās Vācijas okupācijas laikā, īpašu uzmanību pievēršot pretošanās kustības būtības izpratnei un aktuāliem pētniecības jautājumiem.
Harmoni Keberagaman pada Pemahaman Moderasi Beragama dan Penguatan Nilai-Nilai Kebangsaan di Vihara Siddharta Tangerang
Authors: Damana I Ketut 
Published: September 2023

The goal of diversity harmony is religious moderation towards national values at the Siddharta monastery. The previous problem was that there were difficulties in building national insights and after being given guidance there was meaning to the values of Pancasila. By conducting this research, it is hoped that after providing an overview of the relationship between Religious Moderation and National Values, there will be an increase in harmony at the Siddharta Tangerang Temple. From the main findings of this research effort, there were previous difficulties for teachers providing an understanding of national values so that the effect of reduced understanding of moderation at the Siddharta Temple. after guidance there is the contribution of the teacher as one of the strengths in the formation of religious moderation. The research method used is descriptive method with a qualitative approach. Data collection through in-depth interactive observations and interviews and findings from research results on religious moderation of strength, courage, honesty and self-esteem. Likewise, these findings provide more understanding of the importance of national values such as; consensus, the 1945 Constitution, and Bhinneka Tunggal Ika. Also efforts of Buddhist values such as; Metta, Karuna, Mudita and Upekkha.AbstrakTujuan harmoni keberagaman pada moderasi beragama terhadap nilai-nilai kebangsaan di Vihara Siddharta. Masalah sebelumnya terdapat kesulitan untuk membangun wawasan kebangsaan dan setelah diberikan bimbingan adanya makna pada nilai Pancasila. Dengan melakukan penelitian ini, diharapkan setelah diberikan gambaran keterkaitan antara Moderasi Beragama dengan Nilai-nilai Kebangsaan terdapat adanya peningkatan harmoni di Vihara Siddharta Tangerang. Upaya-upaya penelitian ini dari temuan utama terdapat sebelumnnya kesulitan guru memberikan pemahaman nilai-nilai kebangsaan sehingga berpengaruh pemahaman moderasi berkurang di Vihara Siddharta. setelah adanya bimbingan terdapat adanya kontribusi guru sebagai salah satu kekuatan terbentuknya moderasi beragama. Metode penelitian yang digunakan adalah metode deskriptif dengan pendekatan kualitatif. Pengumpulan data melalui interaktif secara mendalam pengamatan dan wawancara dan temuan dari hasil penelitian pada moderasi beragama adanya kekuatan, keberanian, kejujuran dan harga diri. Begitu juga temuan ini memberikan pemahaman yang lebih pada pentingnya nilai-nilai kebangsaan seperti; konsensus, UUD 1945, dan Bhinneka Tunggal Ika. Juga upaya-upaya nilai Buddhis seperti; metta, karuna, mudita dan upekha.