bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of composition and study of sorbent properties based on saponite
Authors: Zubkova Olga , Pyagay Igor , Pankratieva Ksenia , Toropchina Maria 
Published: March 2023

The development of a comprehensive approach to preventing the pollution of natural objects is necessary due to the high requirements of environmental legislation for the discharge of industrial wastewater. Adsorbents are used in various industries to extract heavy metals from wastewater. In this study the possibility of using saponite clay as a raw material for the production of sorbent for the extraction of copper ions Cu2+ from industrial wastewater is considered, a recipe and technology of sorbent production are developed, and its chemical composition is established. It has been established that the optimum temperature for heat treatment of the sorbent and corresponds to 550 ºC, since at this temperature saponite extrudates acquire strength (strength 34.1 kg/mm2) and textural properties (specific surface area of pellets 22.803 m2/g), allowing them to be used as sorbents. The kinetics of molecular adsorption was studied using model solutions of copper (II) sulfate. The extraction efficiency of copper (II) ions from the model solutions is 93 %. Extraction efficiency of copper (II) ions from copper plating wastewater reaches 94 %. SEM results confirm the presence of metal on the sorbent surface.
Segmentasi Pasar Wisatawan di Provinsi Banten
Authors: Soepardi Arya Nugraha , Khoir M. Henfi Abdul 
Published: March 2023

Perkembangan pariwisata di setiap wilayah dinilai sangat penting karena memberikan berbagai dampak positif terhadap pertumbuhan ekonomi di daerah tersebut. Provinsi Banten merupakan salah satu wilayah yang memiliki potensi pariwisata yang besar yang meliputi 279 wisata alam, 49 daya wisata budaya, 61 wisata buatan, 48 wisata minat khusus dan 110 wisata religi. Selain itu, terdapat 10 museum, 116 situs purbakala dan 61 bangunan bersejarah. disertai beberapa unit bisnis penunjang sektor pariwisata yang meliputi: rumah makan, akomodasi, dan biro perjalanan wisata. Tujuan Penelitian ini mengetahui karakteristik, minat, serta motivasi wisatawan berkunjung ke destinasi wisata di Provinsi Banten serta harapan wisatawan terhadap destinasi tersebut. Penelitian ini menggunakan metode primer yang meliputi observasi, survei dengan wawancara dan kuesioner, Selain itu metode sekunder juga digunakan dengan menggunakan berbagai jenis dokumen kebijakan dan peraturan, dokumen perencanaan, data statistik, dan lainnya, Hasil Penelitian ini menggambarkan segmentasi, motivasi, serta harapan wisatawan terhadap berbagai destinasi Pariwisata di Provinsi Banten.
Analisis Pelaksanaan Rekrutmen dan Seleksi Karyawan Oranger Mobile pada PT Pos Indonesia (Persero)
Authors: Patricia Mei Switta , Hersusetiyati Hersusetiyati 
Published: March 2023

Penelitian ini dilakukan untuk mengetahui bagaimana upaya PT Pos Indonesia (Persero) dalam memperoleh karyawan Oranger Mobile yang berkualitas yang dapat mendukung serta melancarkan kegiatan operasional perusahaan dalam mencapai target yang ditetapkan. Tujuan dari penelitian ini yaitu untuk mengetahui bagaimana proses pelaksanaan rekrutmen dan seleksi karyawan Oranger Mobile pada PT Pos Indonesia (Persero). Penelitian ini menggunakan pendekatan kualitatif melalui metode wawancara yang dilakukan terhadap pimpinan beserta staff yang terkait. Adapun hasil penelitian menyatakan bahwa pelaksanaan rekrutmen oranger dilakukan atas dasar permintaan tenaga kerja yang didasari oleh kebutuhan bisnis. Rekrutmen bermula dari adanya data formulir pelamar yang masuk kedalam website Sim Kemitraan yang diisi oleh pelamar melalui website rekrutmen karyawan/ website kemitraan yang disediakan perusahan. Sedangkan proses seleksi dilakukan setelah melihat kelengkapan data dan persyaratan dari setiap lamaran yang masuk dan sudah memenuhi kualifikasi rekrutmen yang ditetapkan. Kesimpulan dari penelitian ini yaitu, baik proses rekrutmen maupun seleksi yang diterapkan oleh PT Pos Indonesia (Persero) terhadap karyawan Oranger Mobile berjalan dengan efektif dan efisien, sesuai dengan Standard Operational Prosedure (SOP) yang ditetapkan oleh perusahaan dan juga dinilai sesuai dengan teori proses rekrutmen dan seleksi.
ISTILAH-ISTILAH DALAM PERADILAN ISLAM
Authors: Putra Eka 
Published: March 2023

Islamic Courts indeed have some sense of the terminology in the law. The terminology can be called by al-Qada 'al-adl / al-qist, al-hukm, al-iffa', and al-ijtihad. In this case, there are differences in the terms used in discussing and establishing a law. Because of differences all settings are based on existing ahwal and when it happens. The scope of the al-Qada 'is related to the implementation of syariah law in a particular case, which is intended for the realization of peace and well-being of the flesh. Formally, it was done by someone who is authorized to carry out these tasks in a particular area. The decision authorized person is obligated, with the meaning of words must be followed by those who stuck with what was decided that. The objective here is opposed to the wicked. People who transgress his testimony can not be accepted. Al-Hukm (plural al-Ahkam) is etymologically synonymous with al-Bukhari, al-fiqh, al-Qada 'bi al-'adl. Al-Hukm also means arrested. Ijtihad is an ability to exert maximum effort to achieve something.Peradilan Islam sesungguhnya memiliki beberapa peristilahan dalam mengertikan hukum. Peristilahan itu bisa disebut dengan al-qada', al-adl/al-qist, al-hukm, al-iffa', dan al-ijtihad. Dalam hal ini ternyata terdapat perbedaan istilah yang dipakai dalam membahas dan menetapkan sesuatu hukum. Karena adanya perbedaan kasus-kasus itu. Semua penetapan itu didasarkan kepada ahwal yang ada dan terjadi ketika itu.Ruang lingkup al-qada' adalah menyangkut pelaksanaan hukum syara' dalam suatu kasus tertentu, yang bertujuan agar terwujudnya ketentraman dan kemaslahatan hidup duniawi. Secara formal hal itu dilakukan oleh seseorang yang diberi wewenang untuk melaksanakan tugas tersebut dalam wilayah tertentu. Keputusan orang yang berwenang tersebut sifatnya mengikat, dengan arti kata wajib dipatuhi oleh orang yang tersangkut dengan perkara yang diputuskan itu. Adil di sini merupakan lawan dari fasiq. Orang yang fasiq tidak dapat diterima kesaksiannya. Al-Hukm (jamaknya al-ahkam) secara etimologi sinonim dengan al-'ilm, al-fiqh, al-qada' bi al-'adl. Al-Hukm juga bearti menahan. Ijtihad adalah mengerahkan suatu kemampuan secara maksimal untuk mencapai sesuatu.
QADHA SHALAT BAGI ORANG PINGSAN (STUDI KOMPARATIF PENDAPAT ULAMA)
Authors: Julir Nenan 
Published: March 2023

Shalat has a high position among other acts of worship. It is the prayer that accompanies the journey of human life all the time, at least five (5) times a day and night shall be done by humans. In fact, human life would not be fit at all times, sometimes they experienced pain, fainting so that prayer is neglected. Shall neglected prayer be replaced by / qadha or not? In this regard the fuqaha have different opinions on determining the law. Here the author tried to compare the opinions and arguments of each Imam mazhab to take a valid opinion. Ibadah shalat memiliki kedudukan yang tinggi di antara ibadah-ibadah yang lain. Ia adalah ibadah yang mengiringi perjalanan hidup manusia sepanjang waktu, minimal lima (5) kali sehari semalam wajib dikerjkan oleh manusia. Kenyataannya perjalanan hidup manusia tidak selalu prima sepanjang waktu, adakalnya mengalami sakit, pingsan misalnya sehingga shalat terabaikan.Shalat yang terabaikan itu apakah wajib diganti/diqadha atau tidak? Berkenaan dengan hal ini para fuqaha berselisih pendapat dalam menetapkan hukumnya. Di sini penulis mencoba mengkomparasikan pendapat dan dalil dari masing-masing Imam mazhab, untuk mengambil pendapat yang lebih kuat. Ibadah shalat memiliki kedudukan yang tinggi di antara ibadah-ibadah yang lain. Ia adalah ibadah yang mengiringi perjalanan hidup manusia sepanjang waktu, minimal lima (5) kali sehari semalam wajib dikerjkan oleh manusia. Kenyataannya perjalanan hidup manusia tidak selalu prima sepanjang waktu, adakalnya mengalami sakit, pingsan misalnya sehingga shalat terabaikan.Shalat yang terabaikan itu apakah wajib diganti/diqadha atau tidak? Berkenaan dengan hal ini para fuqaha berselisih pendapat dalam menetapkan hukumnya. Di sini penulis mencoba mengkomparasikan pendapat dan dalil dari masing-masing Imam mazhab, untuk mengambil pendapat yang lebih kuat.
Nerve ECM and PLA-PCL based electrospun bilayer nerve conduit for nerve regeneration
Authors: Mao Xiaoyan , Li Ting , Cheng Junqiu , Tao Meihan , Li Zhiyuan , Ma Yizhan , Javed Rabia , Bao Jie , Liang Fang , Guo Weihong , Tian Xiaohong , Fan Jun , Yu Tianhao , Ao Qiang 
Published: March 2023

Introduction: The porcine nerve-derived extracellular matrix (ECM) fabricated as films has good performance in peripheral nerve regeneration. However, when constructed as conduits to bridge nerve defects, ECM lacks sufficient mechanical strength.Methods: In this study, a novel electrospun bilayer-structured nerve conduit (BNC) with outer poly (L-lactic acid-co-ε-caprolactone) (PLA-PCL) and inner ECM was fabricated for nerve regeneration. The composition, structure, and mechanical strength of BNC were characterized. Then BNC biosafety was evaluated by cytotoxicity, subcutaneous implantation, and cell affinity tests. Furthermore, BNC was used to bridge 10-mm rat sciatic nerve defect, and nerve functional recovery was assessed by walking track, electrophysiology, and histomorphology analyses.Results: Our results demonstrate that BNC has a network of nanofibers and retains some bioactive molecules, including collagen I, collagen IV, laminin, fibronectin, glycosaminoglycans, nerve growth factor, and brain-derived neurotrophic factor. Biomechanical analysis proves that PLA-PCL improves the BNC mechanical properties, compared with single ECM conduit (ENC). The functional evaluation of in vivo results indicated that BNC is more effective in nerve regeneration than PLA-PCL conduit or ENC.Discussion: In conclusion, BNC not only retains the good biocompatibility and bioactivity of ECM, but also obtains the appropriate mechanical strength from PLA-PCL, which has great potential for clinical repair of nerve defects.
Rapid and sensitive detection of superoxide dismutase in serum of the cervical cancer by 4-aminothiophenol-functionalized bimetallic Au-Ag nanoboxs array
Authors: Xia Ji , Chen Gao-Yang , Li You You , Chen Lu , Lu Dan 
Published: March 2023

Early, efficient and sensitive detection of serum markers in cervical cancer is very important for the treatment and prognosis to cervical cancer patients. In this paper, a SERS platform based on surface enhanced Raman scattering technology was proposed to quantitatively detect superoxide dismutase in serum of cervical cancer patients. Au-Ag nanoboxs array was made by oil-water interface self-assembly method as the trapping substrate. The single-layer Au-AgNBs array was verified by SERS for possessing excellent uniformity, selectivity and reproducibility. 4-aminothiophenol (4-ATP) was used as Raman signal molecule, it will be oxidized to dithiol azobenzene under the surface catalytic reaction with the condition of PH = 9 and laser irradiation. The quantitative detection of SOD could be achieved by calculating the change of characteristic peak ratio. When the concentration was from 10 U mL−1–160 U mL−1, the concentration of SOD could be accurately and quantitatively detected in human serum. The whole test was completed within 20 min and the limit of quantitation was 10 U mL−1. In addition, serum samples from the cervical cancer, the cervical intraepithelial neoplasia and healthy people were tested by the platform and the results were consistent with those of ELISA. The platform has great potential as a tool for early clinical screening of cervical cancer in the future.
Preparation of a 3D printable high-performance GelMA hydrogel loading with magnetic cobalt ferrite nanoparticles
Authors: Shi Yiwan , Wang Zhaozhen , Zhou Xinting , Lin Chengxiong , Chen Chao , Gao Botao , Xu Weikang , Zheng Xiaofei , Wu Tingting , Wang Huajun 
Published: March 2023

Osteosarcoma remains a worldwide concern due to the poor effectiveness of available therapies in the clinic. Therefore, it is necessary to find a safe and effective therapy to realize the complete resection of osteosarcoma and reconstruction of the bone defect. Magnetic hyperthermia based on magnetic nanoparticles can kill tumor cells by raising the temperature without causing the side effects of conventional cancer treatments. This research aims to design a high-performance magnetic hydrogel composed of gelatin methacrylate and highly magnetic cobalt ferrite (CFO) nanoparticles for osteosarcoma treatment. Specifically, CFO is surface functionalized with methacrylate groups (MeCFO). The surface modified CFO has good biocompatibility and stable solution dispersion ability. Afterward, MeCFO nanoparticles are incorporated into GelMA to fabricate a three-dimensional (3D) printable MeCFO/GelMA magnetic hydrogel and then photocross-linked by UV radiation. MeCFO/GelMA hydrogel has high porosity and swelling ability, indicating that the hydrogel possesses more space and good hydrophily for cell survival. The rheological results showed that the hydrogel has shear thinning property, which is suitable as a bioprinting ink to produce desired structures by a 3D printer. Furthermore, 50 μg/mL MeCFO not only decreases the cell activity of osteosarcoma cells but also promotes the osteogenic differentiation of mBMSCs. The results of the CCK-8 assay and live/dead staining showed that MeCFO/GelMA hydrogel had good cytocompatibility. These results indicated that MeCFO/GelMA hydrogel with potential antitumor and bone reconstruction functions is a promising therapeutic strategy after osteosarcoma resection.
Suppression of SMOC2 alleviates myocardial fibrosis via the ILK/p38 pathway
Authors: Rui Huang , Zhao Fang , Yuhua Lei , Hong Jiang 
Published: March 2023

BackgroundFibrosis of the myocardium is one of the main pathological changes of adverse cardiac remodeling, which is associated with unsatisfactory outcomes in patients with heart disease. Further investigations into the precise molecular mechanisms of cardiac fibrosis are urgently required to seek alternative therapeutic strategies for individuals suffering from heart failure. SMOC2 has been shown to be essential to exert key pathophysiological roles in various physiological processes in vivo, possibly contributing to the pathogenesis of fibrosis. A study investigating the relationship between SMOC2 and myocardial fibrosis has yet to be conducted.MethodsMice received a continuous ISO injection subcutaneously to induce cardiac fibrosis, and down-regulation of SMOC2 was achieved by adeno-associated virus-9 (AAV9)-mediated shRNA knockdown. Neonatal fibroblasts were separated and cultured in vitro with TGFβ to trigger fibrosis and infected with either sh-SMOC2 or sh-RNA as a control. The role and mechanisms of SMOC2 in myocardial fibrosis were further examined and analyzed.ResultsSMOC2 knockdown partially reversed cardiac functional impairment and cardiac fibrosis in vivo after 21 consecutive days of ISO injection. We further demonstrated that targeting SMOC2 expression effectively slowed down the trans-differentiation and collagen deposition of cardiac fibroblasts stimulated by TGFβ. Mechanistically, targeting SMOC2 expression inhibited the induction of ILK and p38 in vivo and in vitro, and ILK overexpression increased p38 phosphorylation activity and compromised the protective effects of sh-SMOC2-mediated cardiac fibrosis.ConclusionTherapeutic SMOC2 silencing alleviated cardiac fibrosis through inhibition of the ILK/p38 signaling, providing a preventative and control strategy for cardiac remodeling management in clinical practice.
Exploring the perceptions of lecturers and final year students about the infusion of inclusion in initial teacher education programmes in South Africa
Authors: Nel Mirna , Hay Johnnie , Bekker Tanya , Beyers Christa , Pylman Nicky , Alexander Gregg , Matoti Sheila 
Published: March 2023

IntroductionSouth Africa embraced the move to inclusive education after the political transformation in 1994 by partaking in and subscribing to the international Education for All (EFA) drive initiated in 1990 at the Jomtien World Conference on Education for All, which declared that all children, youth and adults should receive a basic education. Furthermore, the Salamanca Statement of 1994 the United Nations (UN) Convention on the Rights of Persons with Disabilities (CRPD) of 2006 and the Sustainable Development Goal 4 are internationally regarded as the most important influence on the transformation of education systems to become more inclusive and consequently continue to have an important influence on education policies and practices in South Africa. The key policy driving inclusive education in South Africa is Education White Paper 6 (EWP6). EWP6 affirms that teachers play a central role in implementing an inclusive education system. Therefore, training is emphasized as a key strategy to enable educators to become more inclusive in their teaching practices. The focus of this article is on Initial Teacher Education (ITE) for inclusion. Influenced by international developments to transform ITE programmes and the national endorsement of inclusive education the Department of Higher Education and Training (DHET) embarked on a project called the Teaching and Learning Capacity Development Improvement Project (TLCDIP). The project reported on in this article was one facet of the TLCDIP and focused specifically on teacher education for inclusion in the Foundation (Reception to Grade 3) and Intermediate Phases (Grade 4 to 6) of the Baccalaureus Educationis (B Ed) programme.MethodsThe primary research aim was: To explore the perceptions of final year students and their lecturers in ITE programmes regarding the preparation of pre-service teachers for teaching in inclusive and diverse learning environments. A qualitative research approach was employed to gain in-depth and rich data. Purposive sampling was used including final year students and their lecturers. Open questionnaires and group interviews were employed as data generation strategies.ResultsAn inductive thematic analysis showed that the following themes were identified by the participants as critical to be considered in the development and implementation of ITE programmes: Understanding inclusive education, which is also linked to knowledge; the disconnect between theory and practice, the lack of knowledge and practical experience regarding inclusive teaching strategies and how inclusion is addressed in the B Ed curriculum.
Optimization of the adsorption of lead (II) by hydroxyapatite using a factorial design: Density functional theory and molecular dynamics
Authors: El Hammari L. , Hamed R. , Azzaoui K. , Jodeh S. , Latifi S. , Saoiabi S. , Boukra O. , Krime A. , Boukra A. , Saoiabi A. , Hammouti B. , Khan M. M. , Sabbahi R. , Hanbali G. , Berisha A. , Taleb M. , Dagdag O. 
Published: March 2023

Hydroxyapatite (HAp) synthesized through a wet chemical procedure was used to adsorb lead (II) from an aqueous solution. HAp was characterized using Fourier transform infrared, X-ray diffraction, Brunauer–Emmett–Teller analysis, and scanning electron microscopy. The removal of Pb+2 was investigated using the factorial design approach to investigate the efficiency of different Pb+2 concentrations, adsorption contact time, and HAp mass. The greatest Pb+2 removal (98.94%) was obtained at a starting concentration of 50 mg/L, a contact period of 15 min, and a pH of 8. At 323 K, the isothermal adoption module was fitted to the Langmuir isotherms with a regression coefficient (R2) of 0.96. The thermodynamic calculations revealed that the adsorption process was exothermic, spontaneous, and predominantly dominated by chemisorption. Furthermore, the maximum adsorption capacity (Qmax) at equilibrium was 90.18 mg/g, and the adsorption kinetics was specified by a pseudo-second-order kinetic model. Density functional theory and theoretical studies showed that the results of the experiment were correlated by the observation of a much higher negative Eads value for the lead ion adsorbate molecules as they attached to the surface of the adsorbent.
KLF4 loss in hepatocellular carcinoma: Improving prognostic prediction and correlating immune infiltrates
Authors: Chen Desheng , Zhu Qi , Li Tiewen , Fan Xuhui , Lou Yichao , Zhang Yi , Huang Kejie , Sun Hongcheng 
Published: March 2023

Introduction: Although the molecular mechanisms of Krüpple-like factor 4 (KLF4) as a tumor suppressor in HCC tumorigenesis have been thoroughly examined, its clinical application in terms of precise prognostication and its influence on tumor immune microenvironment in patients with HCC require further investigation.Methods: Bioinformatics and immunohistochemistry (IHC) were used to validate KLF4 expressions in a tissue microarray (TMA) containing HCC samples. Using Cox regression models, independent prognostic factors were identified and employed in the development of nomograms. Decision curve analysis (DCA) demonstrated the superiority of the nomograms. GO and KEGG pathway analyses were applied to the functional study of KLF4. The GSVA program explored the link between KLF4 expression and tumor-infiltrating immune cells, and CAMOIP was used to construct KLF4 expression immune scores. Changes in immune-related gene markers were also investigated in relation to KLF4 expression. The association between immune cell infiltration and KLF4 expression was validated by IHC in TMA.Results: HCC was reported to have a notable depletion of KLF4. The absence of KLF4 was associated with advanced clinicopathological characteristics of HCC and predicted a bad prognosis for patients. Nomograms constructed using KLF4 expression, tumor differentiation, and TNM stage provided a more accurate prognostic assessment of HCC patients than TNM stage alone. KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8+ T cells, and other immune cells, and elevation of immune checkpoints. Higher levels of CD8+ T cells and macrophage infiltration are associated with increased KLF4 expression in HCC TMA.Conclusion: KLF4 loss in HCC is a prognostic biomarker that influences the tumor immune microenvironment (TIME).