bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Transcriptome Combined with Morphophysiological Analyses Revealed Carotenoid Biosynthesis for Differential Chilling Tolerance in Two Contrasting Rice (Oryza sativa L.) Genotypes
Authors: Zhang Peng , Wu Xiang , Chen Yulin , Ji Guangmei , Ma Xinling , Zhang Yuping , Xiang Jing , Wang Yaliang , Wang Zhigang , Li Liangtao , Chen Huizhe , Zhang Yikai 
Published: September 2023

Abstract
Early spring cold spells can lead to leaf chlorosis during the rice seedling greening process. However, the physiological and molecular mechanisms underlying the rice greening process under low-temperature conditions remain unknown. In this study, comparative transcriptome and morphophysiological analyses were performed to investigate the mechanisms mediating the responses of the Koshihikari (Kos) and Kasalath (Kas) rice cultivars to chilling stress. According to their growth-related traits, electrolyte leakage, and chlorophyll fluorescence parameters, Kos was more tolerant to low-temperature stress than Kas. Moreover, chloroplast morphology was more normal (e.g., oval) in Kos than in Kas at 17°C. The comparative transcriptome analysis revealed 610 up-regulated differentially expressed genes that were common to all four comparisons. Furthermore, carotenoid biosynthesis was identified as a critical pathway for the Kos response to chilling stress. The genes in the carotenoid biosynthesis pathway were expressed at higher levels in Kos than in Kas at 17°C, which was in accordance with the higher leaf carotenoid content in Kos than in Kas. The lycopene β-cyclase and lycopene ε-cyclase activities increased more in Kos than in Kas. Additionally, the increases in the violaxanthin de-epoxidase and carotenoid hydroxylase activities in Kos seedlings resulted in the accumulation of zeaxanthin and lutein and mitigated the effects of chilling stress on chloroplasts. These findings have clarified the molecular mechanisms underlying the chilling tolerance of rice seedlings during the greening process.
Large-Scale Cultural Heritage Conservation and Utilization Based on Cultural Ecology Corridors: A Case Study of the Dongjiang-Hanjiang River Basin in Guangdong, China
Authors: Sun Ying , Wang Yushun 
Published: September 2023

Abstract
In China, cultural heritage conservation is benefiting from a trend of regionalization and integration. Additionally, the combination of culture and surroundings has typically been a requirement for international heritage conservation. Through the construction of large-scale cultural ecology corridors, heritage and surroundings can be integrated to explore the interaction between culture and natural ecology.The Dongjiang and Hanjiang River Basin is a representative area with great cultural and ecological value for both Guangdong Province and the whole country. However, some problems exist, such as the significant isolation of cultural heritage sites, the insufficient connectivity of ecological patches and the insufficient development of the cultural ecology economy. Morphological spatial pattern analysis (MSPA), minimum cumulative resistance (MCR) and other methods were used to construct the cultural ecology corridor of the Dongjiang-Hanjiang River Basin, coordinate cultural and ecological resources, and establish a cross-regional and large-scale cultural and surroundings research framework. To realize the overall conservation and utilization of cultural ecology resources in the basin, pass on Lingnan culture, promote the overall development of heritage sites along the corridor, and create a demonstration base for the conservation and value of Chinese cultural ecology, efforts should be implemented to clarify the cultural routes, repair the natural ecological system and build a corridor cultural ecology economic belt. At both the national and international level, these actions address current human conservation and construction requirements for better cultural and ecological environments; furthermore, they are important for achieving sustainable development.
Congenital Diaphragmatic Hernia: Improving Outcomes using a Maximal Lung Protection Strategy and Early Surgery
Authors: Bromiker Ruben , Sokolover Nir , Ben-Hemo Inbar , Idelson Ana , Gielchinsky Yuval , Almog Anastasia , Zeitlin Yelena , Herscovici Tina , Klinger Gil 
Published: September 2023

Abstract
Purpose: To evaluate the effectiveness of a novel protocol, adopted in our institution, for improving outcomes of congenital diaphragmatic hernia (CDH)
Mehtods: A maximal lung protection (MLP) protocol was implemented in 2019. This strategy included immediate use of high frequency oscillatory ventilation (HFOV) after birth, during stay at the Neonatal Intensive Care Unit (NICU) and during surgical repair. HFOV strategy included low distending pressures and higher frequencies (15 Hz) with subsequent lower tidal volumes. Surgical repair was performed early, within 24 hours of birth, if possible.
A retrospective study of all inborn neonates prenatally diagnosed with CDH and without major associated anomalies was performed at the NICU of Schneider Children's Medical Center of Israel between 2009 and 2022. Survival rates and pulmonary outcomes of neonates managed with MLP were compared to standard care.
Results: 33 neonates were managed with the MLP protocol vs. 39 neonates that were not. Major adverse outcomes decreased including death rate from 46% to 18% (p= 0.012), extracorporeal membrane oxygenation from 39% to 0% (p<0.001) and pneumothorax from 18% to 0% (p=0.013).
Conclusion(s): MLP with early surgery significantly improved survival and additional adverse outcomes of neonates with CDH. Prospective randomized studies are necessary to confirm the findings of the current study.
Biochar from digestate pyrolysis as a filler for biopolymer blends: effect of blend composition
Authors: Infurna Giulia , Botta Luigi , Ingargiola Irene , Maniscalco Marco , Caputo Giuseppe , Dintcheva Nadka Tz. 
Published: September 2023

Abstract
This study investigates biochar (BC) composites based on biopolymer blends, focusing on the effect of the biopolymer weight ratio on the final BC composites. The blends studied in this work were obtained by varying the weight ratio of poly-butylene adipate-co-terephthalate (PBAT) and polylactic acid (PLA) due to their great importance in packaging and agricultural fields. In particular, BC has been produced in our laboratories by the slow pyrolysis of the digestate obtained from the anaerobic digestion of the organic fraction of municipal solid waste (OFMSW). The effect of BC on PBAT and PLA biopolymer matrices is different, and for the blend compositions the relative weight ratio between PBAT and PLA plays an important role. In order to better investigate the filler/polymer interactions, biochar particles were dimensionally, morphologically and chemically characterised. The biocomposite blend has been fully characterised: Rheological, morphological, mechanical and dynamic-mechanical characterisations have been carried out, highlighting that a strong chemical interaction occurs between PLA and BC particles.
Real-world dispensing of buprenorphine in California during prepandemic and pandemic periods
Authors: Wang Yun , Chan Alexandre , Beuttler Richard , Schneberk Todd , Nichol Michael 
Published: September 2023

Abstract

Buprenorphine, the primary take-home medication for individuals with moderate to severe opioid use disorder (OUD), faced potential disruptions during the COVID-19 pandemic. While previous studies have focused on short-term effects, our comprehensive analysis spans 33 months, leveraging California's prescription drug monitoring program (PDMP). Our findings reveal that the pandemic moderated the growth of prescriber numbers but had minimal impact on monthly patient volumes, prescriptions, or daily dosage.
Protein restriction slows the development and progression of Alzheimer's disease in mice
Authors: Babygirija Reji , Sonsalla Michelle M. , Han Jessica H. , James Isabella , Green Cara L. , Calubag Mariah F. , Mill Jericha , Wade Gina , Tobon Anna , Michael John , Trautman Michaela M. , Matoska Ryan , Yeh Chung-Yang , Grunow Isaac , Pak Heidi H. , Rigby Michael J. , Denu John M. , Puglielli Luigi , Simcox Judith , Lamming Dudley W. 
Published: September 2023

Abstract

Over the last decade, it has become evident that dietary protein is a critical regulator of metabolic health and aging. Low protein diets are associated with healthy aging in humans, and we and others have shown that dietary protein restriction (PR) extends the lifespan and healthspan of mice. Here, we examined the effect of PR on metabolic health and the development and progression of Alzheimer’s disease (AD) in the 3xTg mouse model of AD. We found that PR has metabolic benefits for 3xTg mice and non-transgenic controls of both sexes, promoting leanness and glycemic control in 3xTg mice. We found that PR induces sex-specific alterations in circulating metabolites and in the brain lipidome, downregulating sphingolipid subclasses including ceramides, glucosylceramides, and sphingomyelins in 3xTg females. Consumption of a PR diet starting at 6 months of age reduced AD pathology in conjunction with reduced mTORC1 activity, increased autophagy, and had cognitive benefits for 3xTg mice. Finally, PR improved the survival of 3xTg mice. Our results demonstrate that PR slows the progression of AD at molecular and pathological levels, preserves cognition in this mouse model of AD, and suggests that PR or pharmaceutical interventions that mimic the effects of this diet may hold promise as a treatment for AD.
Literatura quechua contemporánea del Perú: continuidades y aperturas en la poesía
Authors: Mamani Macedo Mauro Félix 
Published: September 2023

El objetivo de este artículo es presentar las continuidades y aperturas temáticas y formales en la poesía quechua contemporánea. En la poesía quechua no existe una sistematización respecto de la fértil producción poética contemporánea que muestra una pluralidad de vertientes. Para ello, primero proponemos una introducción; luego, un examen de las continuidades en forma comparativa; finalmente, un análisis de las nuevas propuestas temáticas surgidas del impacto de la modernidad y la modernización. Se aplica para el análisis la semiótica de la cultura (semiosfera), los estudios latinoamericanos (totalidad contradictoria) y categorías andinas (ayni, pachakuti). Con ello demostramos que la poesía quechua contemporánea se alimenta de dos fuentes: la tradición nativa y los desarrollos de la modernidad, lo que genera persistencias y novedades en su representación.
PROTOTYPE ALAT PENCACAH SAMPAH PLASTIK TERKONEKSI ANDROID DENGAN SUMBER PANEL SURYA
Authors: Soedjarwanto Noer 
Published: September 2023

Limbah sampah Plastik merupakan masalah yang sangat serius bagi Lingkungan Indonesia, dikarenakan plastik merupakan sampah yang sulit terurai oleh bakteri. Plastik memerlukan puluhan bahan ratusan tahun agar dapat terurai alami oleh bakteri. Walaupun demikian limbah plastik dapat menjadi berguna apabila ia dicacah dan dijual agar mendapatkan nilai jual yang cukup besar untuk memenuhi kebutuhan keluarga sehari hari. Maka dari itu penelitian ini bertujuan untuk merancang dan mengembangkan alat pencacah sampah plastik yang terkoneksi dengan android untuk memudahkan proses pencacah sampah plastik. Pengembangan prototipe ini melibatkan Langkah Langkah perakitan dan pengujian alat pencacah sampah plastik. Penelitian ini menggunakan Node Mcu sebagai microcontroller dengan aplikasi blynk untk mengontrol node mcu melalui internet. Hasil pengujian menunjukkan bahwa alat ini mampu menghancurkan sampah plastik sebanyak 54 gram selama 1 menit. Penelitian ini menggunakan panel surya 100 wp sebagai sumber daya untuk mengecas dua buah aki 6.3 Ah dengan lama pengecasan 8 jam dan habis dalam waktu 36 menit.
Use of a jumbo plate in dogs greater than 50 kg following tibial plateau leveling osteotomy does not prevent increase in tibial plateau angle through convalescence
Authors: MacCormick Mathew R. A. , Daye Robert M. 
Published: September 2023

Abstract

OBJECTIVE
To investigate the use of a locking 3.5/4.0-mm jumbo tibial plateau leveling osteotomy (TPLO) plate in maintaining the postoperative tibial plateau angle (TPA) in giant-breed dogs weighing > 50 kg and to report the associated complications.

ANIMALS
Canine patients weighing > 50 kg that underwent TPLO stabilized with a locking 3.5/4.0-mm jumbo TPLO plate between January 2017 and May 2022.

METHODS
Retrospective case series retrieving postoperative outcomes from the medical records. Healing scores and TPAs were calculated using postoperative and recheck radiographs. Owner-perceived outcomes were obtained via questionnaire.

RESULTS
24 stifles in 22 dogs were included. Postoperative complications were recorded in 11 of 24 cases (45.8%) inclusive of 1 minor, 1 catastrophic, and 9 major complications. A statistically significant increase in TPA over the convalescent period was found. Grade 4 healing was present in 18 of 24 (75%) stifles, while the remainder were scored as grade 3.

CLINICAL RELEVANCE
The use of a locking 3.5/4.0-mm jumbo TPLO plate did not prevent a statistically significant increase in TPA through convalescence. This procedure displayed an unacceptably high complication rate when compared with contemporary literature of TPLO. Despite a high complication rate in this patient population, most complications were successfully managed with medical and/or surgical treatment, and high mean and median healing scores were achieved at the radiographic recheck. Additionally, owner-perceived long-term outcomes were excellent.
EFECTO IN VITRO DE LA INFUSIÓN Y ACEITE ESENCIAL DE Caesalpinia Espinosa (TARA) SOBRE Streptococcus mutans
Authors: Macedo Valdivia Sonia , Cano Araujo Delia , Quispe Eduardo Bonet Antonela , Machaca Huancollo Kely Yudan , Loayza Mamani Whiney Darlin , Padilla Caceres Tania Carola 
Published: September 2023

La Caesalpinia spinosa (Tara) es una planta muy utilizada en la medicina popular que se caracteriza por contener grandes cantidades de taninos en sus vainas, poseyendo actividad antioxidante y antimicrobiana; en cavidad bucal los Streptococcus mutans son los principales microorganismos relacionados a la caries dental y se encuentran en la placa que se deposita en la superficie de los dientes. Los resultados in vitro del efecto inhibidor de la Caesalpinia spinosa fueron obtenidos mediante la prueba de difusión con discos de papel filtro por el método de Kirby Bauer, embebidos con infusión a diferentes concentraciones de 50 %, 75 % y 100 %, y con aceite esencial al 100 %, el control positivo fue la clorhexidina al 0,12 % y el negativo agua destilada. Los resultados mostraron que la infusión de Caesalpinia spinosa en concentraciones de 50 %, 75 % y 100 % tienen efecto inhibitorio sobre las cepas de Streptococcus mutans con un promedio de 14,20 mm, 16,57 mm y 17,11 mm respectivamente a las 24 horas; el aceite esencial al 100 % de Caesalpinia spinosa tiene efecto inhibitorio mayor comparado con la infusión con un promedio de 18,09 mm también a las 24 horas, disminuyendo el efecto de ambos a las 48 horas. Se concluye que la infusión de Caesalpinia spinosa tiene efecto inhibitorio sobre cepas de Streptococcus mutans, y a mayor concentración mayor efectividad. El efecto inhibitorio del aceite esencial de Caesalpinia spinosa es mayor, pero en ambos es mejor a las 24 horas que a las 48 horas.
Tuberculosis en un Distrito de Salud de Ecuador: situación epidemiológica y control de la enfermedad. Años 2017 y 2018
Authors: Pereira Olmos Hugo , Morales-Tonato Gladys , Arguello Efraín , Cruz-Mariño Alexandro , Quishpe-Narváez Erika , Ruffino-Netto Antonio 
Published: September 2023

Introducción: La tuberculosis es la novena causa de muerte en el mundo y la primera de las enfermedades infecciosas. El objetivo del presente trabajo fue describir la situación epidemiológica de la tuberculosis y el alcance de la respuesta de la estrategia de control en un distrito de salud de la serranía del Ecuador.
Materiales y Métodos: estudio descriptivo, con información secundaria de la base de registros de personas con tuberculosis del Distrito de Salud 17D06 Chilibulo – Lloa; los datos de identificación personal se mantuvieron bajo estricto carácter anónimo y confidencial.
Resultados: En el 2017 y 2018 hubo 39 y 44 casos de tuberculosis; el 61% fue de sexo masculino; el 71,8% fueron mayores a 35 años; la tasa de mortalidad fue de 0.02 y 0.97 por cada 100.000 habitantes. La captación fue del 15,5% en el 2017 y 17,9% en el 2018. Las brechas en captación del sintomático respiratorio, diagnóstico de tuberculosis con baciloscopía positiva y su total estuvieron por encima del 80% en ambos años. De los pacientes que iniciaron tratamiento, el 87,2 % terminaron el mismo en el 2017 y el 31,8% en el 2018.
Discusión: La tasa de éxito en el tratamiento en el 2017 es similar a la meta planteada a nivel nacional (87%), algo inferior en el 2018. Los logros en captación también difieren al resto del país (30%),
Conclusión: El distrito de salud realiza un adecuado seguimiento en el tratamiento de personas con tuberculosis, pero falla en la captación de sintomáticos respiratorios.
Hereditary angioedema: Patient journey approach in Mexico.
Authors: Vargas Camaño María Eugenia , Buendía López Yareli Odemaris , Garcés Flores Homero , Guzmán Vázquez Silvia 
Published: September 2023

Objective: To understand the patient’s journey with HAE from symptom initiation to diagnosis, treatment allocation, follow-up, and the impact of the disease on their quality of life in Mexico.
Methods: A survey was administered to the patients with HAE. Participants completed a questionnaire covering five domains: patient journey; effects on productivity, school performance and daily activities; quality of life; anxiety and depression. Responses were analyzed using descriptive statistics.
Results: A total of 17 surveys were analyzed (15 women and 2 men, age range: 23-67 years). Type I HAE was most common (71%), normal C1 inhibitor HAE was 12% and 18% did not know their HAE type. The average disease evolution was 13.7 years and the time from symptom initiation to diagnosis was 20 years. 59% of patients knew of one or two treatments available, 12% knew 3 treatments and 18% were aware of 4 or more, 12% were not aware of any treatments. 53% had a job, 18% referred a severely anxious state, 41% were depressed and all patients referred some social impact due to HAE.
Conclusions: There is a need to reinforce the knowledge of general practitioners on HAE to promote an earlier diagnosis and awareness of rare diseases and their impact on quality of life among the general population and promote the removal of barriers to treatment.
Anais do I Simpósio Brasileiro de Saúde Mental na Medicina
Authors: Lopes Joice Ribeiro , Pires Bárbara Caldeira , Braga Anna Carlinda Arantes de Almeida , Silva Igor Yury , Arão Ana Elisa Choucair Hosken , Fagundes Machado Tamyres Karen 
Published: September 2023

Os Anais do I Simpósio Brasileiro de Saúde Mental são um compilado de trabalhos acadêmicos, pesquisas e discussões realizadas durante o evento de abrangência Nacional. Este evento representa uma iniciativa crucial para promover o debate e a disseminação do conhecimento na área da saúde mental, abordando uma variedade de tópicos relevantes.
Data Mining berbasis Nearest Neighbor dan Seleksi Fitur untuk Deteksi Kanker Payudara
Authors: Setiawan Yohanes 
Published: September 2023

Detecting breast cancer in early stage is not straightforward. This happens because biopsy test requires time to determine whether the type is benign or malignant. Data mining algorithm has been widely used to automate diagnosis of a disease. One of popular algorithms is nearest neighbor based because of its simplicity and low computation. However, too many features can cause low accuracy in nearest neighbor based models. In this research, nearest neighbor based with feature selection is developed to detect breast cancer. Conventional k-Nearest Neighbor (KNN) and Multi Local Means k-Harmonic Nearest Neighbor have been chosen as nearest neighbor based models to experiment. The feature selection method used in this study is filter based, namely Correlation based, Information Gain, and ReliefF. The experimental result shows that the highest recall metric of MLM-KHNN and Information Gain is 94% with 5 features. In brief, MLM-KHNN algorithm with Information Gain can increase the recall of the prediction of breast cancer compared with the conventional K-NN algorithm and have been deployed into website using Streamlit such that the model can be used to detect breast cancer from chosen Wisconsin dataset features.
“Even the apocalypse isn’t the end”: Emotional Numbness and the Reconstruction of Interpersonal Bonding in Nana Kwame Adjei-Brenyah’s Friday Black
Authors: Villamarín-Freire Sara 
Published: September 2023

Abstract
This essay examines the role of waste as a categorizing mechanism in the formation of storyworlds in two of the short stories featured in Nana Kwame Adjei-Brenyah’s Friday Black (2018), “The Era” and “Through the Flash.” These two stories “waste” is a category defined according to the internal rules that govern their respective storyworlds, and in this case it arguably takes inspiration from preexisting classifications that have shaped, and continue to shape, the Black experience in the US under (late) capitalism. Analyzing how the relation between emotions, interpersonal bonding, and waste is constructed in each story, the essay demonstrates that understanding the power of waste as a classifying device helps shed light on mechanisms of oppression, which could contribute to dismantling the resulting classifications as well. (SVF)
Going Viral: The Media Anthropology of the “Quarantine Subject” in the Context of Biopolitics and Psychopolitics
Authors: Nemes Márió Z. 
Published: September 2023

Abstract
This essay explores the outlines of the “quarantine subject,” a construct that has formed along the borderlines of viral, immunological, psychopolitical, and biopolitical metaphors. The focus is grounded in media archeology and media anthropology. Under media anthropology lies a basically German philosophical anthropological tradition that explores the convergence of biological and cultural dimensions. Helmuth Plessner and Arnold Gehlen have only recently been rediscovered in the English-speaking world.1 Hans Belting, for one, has elaborated a triple image anthropology that uses the triad of picture–medium–body in the interpretation of various aesthetic paradigms. This essay maps the convergence between the three dimensions emphasized by Belting and the digital-virtual turn driven by, among other factors, the COVID–19 pandemic and the ensuing lockdowns. The goal is the elaboration of a speculative “quarantine subjectivity model,” one that is determined by geographical and social factors, such as Internet access and technological integration, as well as a relatively “moderate” degree of quarantine measures. (MZN)
Zwei Paradigmen der Pädagogik
Authors: Winkler Michael 
Published: September 2023

Abstract
Two Paradigms of Pedagogy. A Phenomenological Enquiry of Education, to Recognise it as a Praxis of Hope
Using a phenomenological approach, the paper starts with the idea, that culture has come to an end. How could education react on this situation? In answering that question two paradigms of education were identified, one is called the optimistic-pessimistic, which tends to understand education as tradition. The other one accepts the disrupture of culture and insists on education as a cooperative praxis of children and educators, which gains an internal dynamic as a real basis of hope for future.