bluuebunny/crossref_metadata_2025_split huggingface dataset:
Androgen receptor blockade resistance with enzalutamide in prostate cancer results in immunosuppressive alterations in the tumor immune microenvironment
Authors: Xu Pengfei , Yang Joy C , Chen Bo , Nip Christopher , Van Dyke Jonathan E , Zhang Xiong , Chen Hong-Wu , Evans Christopher P , Murphy William J , Liu Chengfei 
Published: May 2023

BackgroundEmerging data suggest that patients with enzalutamide-treated prostate cancer with increased programmed death-ligand 1 (PD-L1) expression may benefit from anti-PD-L1 treatment. Unfortunately, the Phase III IMbassador250 clinical trial revealed that the combination of atezolizumab (a PD-L1 inhibitor) and enzalutamide failed to extend overall survival in patients with castration-resistant prostate cancer (CRPC). However, the mechanisms underlying treatment failure remain unknown.MethodsHuman CRPC C4-2B cells and murine Myc-CaP cells were chronically exposed to increasing concentrations of enzalutamide and the cells resistant to enzalutamide were referred to as C4-2B MDVR and Myc-CaP MDVR, respectively. The mechanisms of action in drug-resistant prostate cancer cells were determined using RNA sequencing analyses, RNA interference, real-time PCR, western blotting, and co-culturing technologies. Myc-CaP and Myc-CaP MDVR tumors were established in syngeneic FVB mice, and tumor-infiltrating leukocytes were isolated after enzalutamide treatment. The stained immune cells were determined by flow cytometry, and the data were analyzed using FlowJo.ResultsImmune-related signaling pathways (interferon alpha/gamma response, inflammatory response, and cell chemotaxis) were suppressed in human enzalutamide-resistant prostate cancer cells. PD-L1 was overexpressed and negatively regulated by androgen receptor signaling in resistant cells and patient with CRPC cohorts. Enzalutamide treatment decreased CD8+T-cell numbers but increased monocytic myeloid-derived suppressor cell (M-MDSC) populations and PD-L1 expression within murine Myc-CaP tumors. Similarly, chemotaxis and immune response-regulating signaling pathways were suppressed, and PD-L1 expression was also increased using enzalutamide-resistant Myc-CaP MDVR cells. Notably, MDSC populations were significantly increased in Myc-CaP MDVR orthotopic tumors compared with those in Myc-CaP parental tumors. Co-culturing bone marrow cells with Myc-CaP MDVR cells significantly promoted MDSC differentiation and shifted towards M2 macrophage skewing.ConclusionsOur study suggests that immunosuppressive signaling can be promoted directly by enzalutamide-resistant prostate cancer cells and may be a potential means by which the efficacy of immune checkpoint inhibitors in enzalutamide-resistant prostate cancer is diminished.
Impact of stent-retriever tip design on distal embolization during mechanical thrombectomy: a randomized in vitro evaluation
Authors: Li Jiahui , Tiberi Riccardo , Bhogal Pervinder , Buhk Jan-Hendrik , Behme Daniel , Tomasello Alejandro , Ribo Marc 
Published: May 2023

Background
Repeated number of passes, clot fragmentation, and distal embolization during mechanical thrombectomy (MT) lead to worse clinical outcomes in acute ischemic stroke. This study aimed to assess the recanalization and embolic outcomes of different stent-retrievers (SRs): open-tip SR (Solitaire X 6×40 mm), closed-tip SR (EmboTrap II 5×33 mm), and filter-tip SR (NeVa NET 5.5×37 mm).

Methods
Stiff-friable clot analogs were used to create middle cerebral artery (M1-MCA) occlusions in a benchtop model. After occlusion, experiments were randomized into one of the three treatment arms. The thrombectomy technique consisted of retrieving the SR into a balloon guide catheter under proximal flow arrest and continuous aspiration. A total of 150 single-attempt cases were performed (50 cases/treatment arm). Distal emboli (>100 µm) were collected and analyzed after each experiment.

Results

Filter-tip SR achieved a non-significantly higher first-pass recanalization rate than open-tip SR and closed-tip SR (66% vs 48% vs 44%; P=0.064). Filter-tip SR prevented clot fragments>1 mm from embolizing distal territories in 44% of cases, compared with 16% in open-tip SR and 20% in closed-tip (P=0.003). There were no significant differences between treatment arms in terms of total emboli count (open-tip=19.2±13.1, closed-tip=19.1±10.7, filter-tip=17.2±13.0; P=0.660). Nonetheless, the number of large emboli (>1 mm) and total area of emboli were significantly lower in the filter-tip arm (n=0.88±1.2, A=2.06±1.85 mm
2
) than in the closed-tip arm (n=2.34±3.38, A=4.06±4.80 mm
2
; P<0.05).

Conclusions
When facing fragment-prone clots, the filter-tip SR significantly reduces the number of large clots (>1 mm) that embolize distally during an MT procedure, which in turn may increase the chances of first-pass complete recanalization.
Evaluating transformative health leadership education for Indigenous health: a mixed methods study
Authors: Lu Michelle , Moinul Dina , Crooks Rachel , Kelly-Turner Kenna , Roze des Ordons Amanda , Keegan David , Roach Pamela 
Published: May 2023

BackgroundThere is an urgent need to improve structural competency and anti-racism education across health systems. Many leaders in health systems have the ability and responsibility to play a significant role in policy change and transforming healthcare delivery to address health inequities and injustices. The aim of this project was to evaluate a new health leadership Indigenous health course: PLUS4I.MethodsA mixed methods design grounded in a pragmatic paradigm was used. Attendees to the first four cohorts (n=75) were sent an invitation to complete a survey evaluating their learning immediately after the completion of PLUS4I. We retrospectively collected self-efficacy ratings from participants who were also invited to participate in a semi-structured interview about their experience in PLUS4I. Descriptive statistical analysis was conducted for the quantitative assessment of the survey data. A qualitative descriptive approach to thematic analysis was used for the qualitative interview data.ResultsA total of 45 completed quantitative evaluations (n=45) were completed across all four cohorts. Paired t-tests were used to show pre-changes and post-changes in self-reported confidence on a 6-point Likert scale across four categories of activities. Improvements were seen in the ratings across all categories of activities, and all were statistically significant (p<0.001). Two overarching themes emerged from the qualitative analysis: breaking down previous knowledge and critical applications; building new knowledge and change-making competencies. The qualitative interviews (n=25) averaged 32:23 min, with 18 female (72%) and 7 male (28%) interview participants.ConclusionFuture work will support expansion of the PLUS4I course into other work environments and faculties, where the learning environment, structure and relevant Truth and Reconciliation Calls to Action may be different. This work responds to the urgent need to create systems-level change to address structural racism and implement high-quality Indigenous health and anti-racism education.
Generation of copper fluoroalkyl complexes (CuRFLn) from chlorotrifluoroethylene and −RF transfer to aroyl chlorides
Authors: Porto Luana L.T.N. , Seifi Moutasem , Johnson Nicole , Baker R. Tom 
Published: May 2023

Given the importance of fluorinated drugs and agrochemicals, fluoroalkylation of organic electrophiles that can be performed at a late stage of chemical synthesis has attracted a flurry of contributions. New fluoroalkyl groups can be obtained by insertion of fluoroalkenes into Cu–H bonds. Chlorotrifluoroethylene undergoes regioselective insertion in its reaction with Stryker's reagent, [CuH(PPh3)]6 and triphos to give [Cu(CFClCF2H)(μ−κ1,κ2-triphos)]2, which mediates the fluoroalkylation of several aroyl chlorides (triphos = bis(2-diphenylphosphinoethyl)-phenylphosphine). In contrast, attempted −RF transfer to aryl iodides instead affords aryl–aryl coupling products.
A Data Mining Framework for Maintenance Prediction of Faulty Products Under Warranty
Authors: Al-Refaie Abbas , Hamdieh Banan Abu 
Published: May 2023

Predicting the sequential patterns of maintenance activities (replacement or repair) with the needed spare parts for faulty products becomes the main challenge to maintenance engineers. This research, therefore, develops a data mining framework for predicting the integrated sequential patterns of maintenance activities and identifying the classification of the frequent components’ spare parts for faulty products under warranty. In this framework, a large data set was mined for products under warranty including product attributes, maintenance activities, and spare parts. Then, data mining techniques were performed to determine the frequent sequence pattern of maintenance activities, involving: the selection of monthly maintenance activities, generalized sequential patterns (GSP), generation of association rules, and rule-based classification with/without considering product attributes. The frequent sequential patterns were validated using testing data. Further, the GSP was applied to determine the frequent sequential patterns of spare parts. Finally, integrated sequential patterns were generated for maintenance activities and spare parts. A case study of water-cooled chiller products was deployed to illustrate the developed framework. The effectiveness of the framework was illustrated with the warranty data mining for a water-cooled chiller. In conclusion, the proposed framework allows maintenance engineers to extract hidden knowledge regarding sequential patterns of maintenance planning and provides valuable information for maintenance prediction.
Improvements of Lagrangian Data Assimilation Tested in the Gulf of Mexico
Authors: Dong Junjie , Sun Luyu , Carton James A. , Penny Stephen G. 
Published: May 2023

Abstract
This study extends initial work by Sun and Penny and Sun et al. to explore the inclusion of path information from surface drifters using an augmented-state Lagrangian data assimilation based on the local ensemble transform Kalman filter (LETKF-LaDA) with vertical localization to improve analysis of the ocean. The region of interest is the Gulf of Mexico during the passage of Hurricane Isaac in the summer of 2012. Results from experiments with a regional ocean model at eddy-permitting and eddy-resolving model resolutions are used to quantify improvements to the analysis of sea surface velocity, sea surface temperature, and sea surface height in a data assimilation system. The data assimilation system assimilates surface drifter positions, as well as vertical profiles of temperature and salinity. Data were used from drifters deployed as a part of the Grand Lagrangian Deployment beginning 20 July 2012. Comparison of experiment results shows that at both eddy-permitting and eddy-resolving horizontal resolutions Lagrangian assimilation of drifter positions significantly improves analysis of the ocean state responding to hurricane conditions. These results, which should be applicable to other tropical oceans such as the Bay of Bengal, open new avenues for estimating ocean initial conditions to improve tropical cyclone forecasting.
Good performance of syphilis rapid diagnostic test kits among young key populations in Thailand
Authors: Kamolrattana Rujirek , Songtaweesin Wipaporn Natalie , Suchartlikitwong Pintip , Sophonphan Jiratchaya , Moonwong Juthamanee , Wongharn Prissana , Khamthi Sasiprapha , Sritammasiri Taweesak , Puthanakit Thanyawee , Anugulruengkitt Suvaporn 
Published: May 2023

Background The prevalence of syphilis is increasing among adolescents and young adults (AYAs) globally. Use of syphilis rapid diagnostic treponemal tests (RDTs) may improve test coverage and same-day treatment. This study aims to determine sensitivity and specificity of two syphilis RDTs. Methods A cross-sectional study was conducted in men who have sex with men and transgender women aged 15–24 years attending a sexual health clinic in Bangkok. Syphilis RDTs used were Determine Syphilis TP and Bioline Syphilis 3.0, using whole blood from finger pricks and venipuncture. Treponemal pallidum electrochemiluminescence assay was used as standard reference. Results From February to July 2022, 200 AYAs with a mean age 21.1 (SD2.1) years were enrolled, including 50 (25.0%) living with HIV. Prevalence of syphilis was 10.5% (95%CI 6.6–15.6), which was higher among AYAs living with HIV (22.0%) compared with AYAs unaffected by HIV (6.7%). Sensitivities of Determine Syphilis TP and Bioline Syphilis 3.0 were 85.7% (95%CI 63.7–97.0) and 66.7% (95%CI 43.0–85.4), respectively. Specificity of both RDTs was 100% (95%CI 98.0–100.0). Performance of RDTs was similar for both specimens. Conclusions Syphilis RDTs have high sensitivity and specificity in diagnosing syphilis. It should be considered for use in sexual health clinics with high syphilis prevalence to initiate treatment promptly.
“There's a lot missing”: Treating survivors of sex trafficking with trauma bonds
Authors: Casassa Kaitlin , Ploss Alexa , Karandikar Sharvari 
Published: May 2023

Summary Survivors of sex trafficking often develop trauma bonds with their traffickers. A trauma bond refers to an intense emotional attachment that can develop between victims and their abusers. Research on trauma bonds is sparse and as such so are practice recommendations for service providers. This study seeks to answer the question: What recommendations do service providers make for working with survivors of sex trafficking suffering from trauma bonding? This qualitative study involved in-depth interviews with 10 participants who were licensed social workers or counselors working directly with survivors. Audio recordings were transcribed and coded utilizing aspects of a grounded theory approach. Findings Three themes emerged: (1) understanding client needs, (2) the relational approach, and (3) using existing modalities. Participants discussed clients’ needs for healthy relationships, education about trauma bonding, and improved material circumstances. The relational approach participants described involves meeting clients where they are at, validating survivors, and establishing facts over feelings. Existing modalities discussed by participants include eye movement desensitization and reprocessing (EMDR) therapy and motivational interviewing (MI). Applications These findings can provide direction for service providers working with survivors of sex trafficking who have trauma bonds. Findings support the need for holistic interventions, and further intervention research is needed to empirically examine the efficacy of EMDR and MI with trauma bonds. Additionally, these findings can inform legislators and policy makers as they consider the needs of survivors.
Minimally Invasive Extirpation of Benign Atrial Cardiac Tumors: Clinical Follow-Up and Survival
Authors: Van Praet Karel M. , Kofler Markus , Wilkens Kristin , Sündermann Simon H. , Meyer Alexander , Hommel Matthias , Jacobs Stephan , Falk Volkmar , Kempfert Jörg 
Published: May 2023

Objective: Evidence determining the optimal treatment for cardiac tumors is rare. We report our midterm clinical outcome and patient characteristics of our series undergoing atrial tumor removal through a right lateral minithoracotomy (RLMT). Methods: From 2015 to 2021, 51 patients underwent RLMT for atrial tumor extirpation. Patients receiving concomitant atrioventricular valvular, cryoablation, and/or patent foramen ovale closure surgery were included. Follow-up was performed using standardized questionnaires (mean: 1,041 ± 666 days). Follow-up involved any tumor recurrence, clinical symptoms, and any recurrent arterial embolization. Survival analysis was successfully achieved in all patients. Results: Successful surgical resection was achieved in all patients. Mean cardiopulmonary bypass and cross-clamping times were 75 ± 36 and 41 ± 22 min, respectively. The most common tumor location was the left atrium ( n = 42, 82.4%). Mean ventilation time was 12.74 ± 17.23 h, intensive care unit stay ranged from 1 to 1.9 days (median: 1 day). Nineteen patients (37.3%) received concomitant surgery. Histopathological analysis showed 38 myxoma (74.5%), 9 papillary fibroelastoma (17.6%), and 4 thrombus (7.8%). Thirty-day mortality was observed in 1 case (2%). One patient (2%) suffered a stroke postoperatively. No patient had a relapse of cardiac tumor. Three patients (9.7%) showed arterial embolization during follow-up. Thirteen follow-up patients (25.5%) were in New York Heart Association class ≤II. Overall survival was 90.2% at 2 years. Conclusions: A minimally invasive approach for benign atrial tumor resection is effective, safe, and reproducible. Of the atrial tumors, 74.5% were myxoma and 82% were located in the left atrium. A low 30-day mortality rate with no manifestation of recurrent intracardiac tumor was observed.
A case of breast cancer: Suppression of lactation-related FDG uptake 2 days after cabergoline administration
Authors: Kuroda Hiroyuki , Yoshizako Takeshi , Yamamoto Nobuko , Kataoka Yuko , Hyakudomi Miki , Itakura Masayuki , Kaji Yasushi 
Published: May 2023

We present a case of a 35-year-old woman with breast cancer in lactation 3 months after childbirth, in which a lactation inhibitor was useful for 18F-FDG PET/CT examination. Via ultrasonography and biopsy with histopathology, we diagnosed the lesion in the upper region of the left breast as invasive ductal carcinoma. She stopped breastfeeding and was administered cabergoline to suppress lactation. Two days after the administration, 18F-FDG PET/CT revealed segmental uptake (10 cm in diameter) and no lactation-related uptakes. Dynamic MRI also revealed a segmental enhancement of the same size as 18F-FDG PET/CT. The lactation inhibitor was useful to delineate the extent of the lesion during the 18F-FDG PET/CT examination.
Health-related quality of life and vulnerability among people with myelodysplastic syndromes: a US national study
Authors: Abel Gregory A. , Hebert Donnie , Lee Cecilia , Rollison Dana , Gillis Nancy , Komrokji Rami , Foran James M. , Liu Jane Jijun , Al Baghdadi Tareq , Deeg Joachim , Gore Steven , Saber Wael , Wilson Steffanie , Otterstatter Michael , Thompson Jason , Borchert Christine , Padron Eric , DeZern Amy , Cella David , Sekeres Mikkael A. 
Published: May 2023

Abstract
Health-related quality of life (HRQoL) and vulnerability are variably affected in patients with myelodysplastic syndromes (MDS) and other cytopenic states; however, the heterogeneity of these diseases has limited our understanding of these domains. The National Heart, Lung, and Blood Institute-sponsored MDS Natural History Study is a prospective cohort enrolling patients undergoing workup for suspected MDS in the setting of cytopenias. Untreated patients undergo bone marrow assessment with central histopathology review for assignment as MDS, MDS/myeloproliferative neoplasm (MPN), idiopathic cytopenia of undetermined significance (ICUS), acute myeloid leukemia (AML) with &lt;30% blasts, or “At-Risk.” HRQoL data are collected at enrollment, including the MDS-specific Quality of Life in Myelodysplasia Scale (QUALMS). Vulnerability is assessed with the Vulnerable Elders Survey. Baseline HRQoL scores from 449 patients with MDS, MDS/MPN, AML &lt;30%, ICUS or At-Risk were similar among diagnoses. In MDS, HRQoL was worse for vulnerable participants (eg, mean Patent-Reported Outcomes Management Information Systems [PROMIS] Fatigue of 56.0 vs 49.5; P &lt; .001) and those with worse prognosis (eg, mean Euroqol-5 Dimension-5 Level [EQ-5D-5L] of 73.4, 72.7, and 64.1 for low, intermediate, and high-risk disease; P = .005). Among vulnerable MDS participants, most had difficulty with prolonged physical activity (88%), such as walking a quarter mile (74%). These data suggest that cytopenias leading to MDS evaluation are associated with similar HRQoL, regardless of eventual diagnosis, but with worse HRQoL among the vulnerable. Among those with MDS, lower-risk disease was associated with better HRQoL, but the relationship was lost among the vulnerable, showing for the first time that vulnerability trumps disease risk in affecting HRQoL. This study is registered at www.clinicaltrials.gov as NCT02775383.
Oral candidiasis and cigarette, tobacco, alcohol, and opium consumption in Rafsanjan, a region in the southeast of Iran
Authors: Khalili Parvin , Movagharipoor Atekeh , Sardari Farimah , Movaghari Pour Fatemeh , Jamali Zahra 
Published: May 2023

Abstract
Background
We investigated the association between oral candidiasis prevalence and cigarette, tobacco, alcohol, and opium consumption in Rafsanjan, a region in the southeast of Iran.

Methods
This cross-sectional study was conducted using the data of Oral Health Branch of Rafsanjan Cohort Study (OHBRCS) as a part of the Rafsanjan Cohort Study (RCS). RCS included in Prospective Epidemiological Research Studies in IrAN (PERSIAN) was begun in 2015 in the Rafsanjan. A full-mouth examination was done by trained dental specialists. Oral candidiasis was diagnosed based on clinical examination. Information about cigarette, tobacco, and opium smoking and alcohol consumption were collected based on data from self-reported questionaries. Univariate and multivariate dichotomous logistics regression were used to assess the association between oral candidiasis and cigarette, tobacco, alcohol, and opium consumption.

Results
Among 8682 participants with mean age of 49.94 years, the prevalence of oral candidiasis was 7.94%. There was a direct association between cigarette smoking in current and former cigarette smokers with an increased odds of oral candidiasis (OR: 3.26, 95% CI: 2.46–4.33 and OR: 1.63, 95% CI: 1.18–2.25 respectively) in fully adjusted models. There was a dose-response relationship between the odds of oral candidiasis and dose (OR: 3.31, 95% CI: 2.38–4.60), duration (OR: 2.48, 95% CI: 2.04–3.95) and number (OR: 3.01, 95% CI: 2.02–4.50) of cigarette smoking in the 4th quartile compared to reference group.

Conclusions
A dose-response relationship was shown between cigarette smoking and increased odds of oral candidiasis.