bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Patients With Takotsubo Syndrome Compared With Type 1 and Type 2 Myocardial Infarction
Authors: Khaloo Pegah , Ledesma Pablo A. , Nahlawi Acile , Galvin Jennifer , Ptaszek Leon M. , Ruskin Jeremy N. 
Published: September 2023

Background
Takotsubo syndrome (TS) and myocardial infarction (MI) share similar clinical and laboratory characteristics but have important differences in causes, demographics, management, and outcomes.

Methods and Results

In this observational study, the National Inpatient Sample and National Readmission Database were used to identify patients admitted with TS, type 1 MI, or type 2 MI in the United States between October 1, 2017, and December 31, 2019. We compared patients hospitalized with TS, type 1 MI, and type 2 MI with respect to key features and outcomes. Over the 27‐month study period, 2 035 055 patients with type 1 MI, 639 075 patients with type 2 MI, and 43 335 patients with TS were identified. Cardiac arrest, ventricular fibrillation, and ventricular tachycardia were more prevalent in type 1 MI (4.02%, 3.2%, and 7.2%, respectively) compared with both type 2 MI (2.8%, 0.8%, and 5.4% respectively) and TS (2.7%, 1.8%, and 5.3%, respectively). Risk of mortality was lower in TS compared with both type 1 MI (3.3% versus 7.9%; adjusted odds ratio [OR], 0.3;
P
<0.001) and type 2 MI (3.3% versus 8.2%; adjusted OR, 0.3;
P
<0.001). Mortality rate (OR, 1.2;
P
<0.001) and cardiac‐cause 30‐day readmission rate (adjusted OR, 1.7;
P
<0.001) were higher in type 1 MI than in type 2 MI.

Conclusions
Patients with type 1 MI had the highest rates of in‐hospital mortality and cardiac‐cause 30‐day readmission. Risk of all‐cause 30‐day readmission was highest in patients with type 2 MI. The risk of ventricular arrhythmias in patients with TS is lower than in patients with type 1 MI but higher than in patients with type 2 MI.
Arginine Vasopressin Plays a Role in Microvascular Dysfunction After ST‐Elevation Myocardial Infarction
Authors: Al‐Atta Ayman , Spray Luke , Mohammed Ashfaq , Shmeleva Evgeniya , Spyridopoulos Ioakim 
Published: September 2023

Background
Coronary microvascular dysfunction (CMD) predicts mortality after ST‐elevation–myocardial infarction (STEMI). Arginine vasopressin (AVP) may be implicated, but data in humans are lacking, and no study has investigated the link between arginine vasopressin and invasive measures of CMD.

Methods and Results

We invasively assessed CMD in 55 patients with STEMI treated with primary percutaneous coronary intervention (PPCI), by measuring the index of microcirculatory resistance after PPCI. In a separate group of 45 patients with STEMI/PPCI, recruited for a clinical trial, we measured infarct size and microvascular obstruction with cardiac magnetic resonance (CMR) imaging at 1 week and 12 weeks post‐STEMI. Serum copeptin was measured at 4 time points before and after PPCI in all patients with STEMI. Plasma copeptin levels fell from 92.5 pmol/L before reperfusion to 6.4 pmol/L at 24 hours. Copeptin inversely correlated with diastolic, but not systolic, blood pressure (r=−0.431,
P
=0.001), suggesting it is released in response to myocardial ischemia. Persistently raised copeptin at 24 hours was correlated with higher index of microcirculatory resistance (r=0.372,
P
=0.011). Patients with microvascular obstruction on early CMR imaging showed a trend toward higher admission copeptin, which was not statistically significant. Copeptin levels were not associated with infarct size on either early or late CMR.

Conclusions
Patients with CMD after STEMI have persistently elevated copeptin at 24 hours, suggesting arginine vasopressin may contribute to microvascular dysfunction. Arginine vasopressin receptor antagonists may represent a novel therapeutic option in patients with STEMI and CMD.
Debated issues in the Church of England: The Roles of Theology and Psychology
Authors: Village Andrew 
Published: September 2023

Abstract
This paper tests whether or not psychological type preferences predicted the extent of liberal versus conservative attitudes towards a range of controversial moral issues among 3,515 clergy and laity from the Church of England who took part in the 2013 Church Times survey. Summated rating scales were produced from Likert items related to four different issues: same-sex relationships, the ordination of women, divorce and remarriage, and cohabitation. After allowing for general theological stance, psychological type preferences for sensing over intuition and thinking over feeling were significantly associated with more conservative attitudes. For theological liberals, sensing types had slightly more conservative moral attitudes, on average, than did intuitive types, but there was no difference among theological conservatives. For theological conservatives, thinking types had slightly more conservative moral attitudes, on average, than did feeling types, but there was no difference among theological liberals.
On the Sources of Water Supply Forecast Error in Western Colorado
Authors: Goble Peter E. , Schumacher Russ S. 
Published: September 2023

Abstract
Annual spring and summer runoff from western Colorado is relied upon by 40 million people, six states, and two countries. Cool season precipitation and snowpack have historically been robust predictors of seasonal runoff in western Colorado. Forecasts made with this information allow water managers to plan for the season ahead. Antecedent hydrological conditions, such as root zone soil moisture and groundwater storage, and weather conditions following peak snowpack also impact seasonal runoff. The roles of such factors were scrutinized in 2020 and 2021: seasonal runoff was much lower than expectations based on snowpack values alone. We investigate the relative importance of meteorological and hydrological conditions occurring before and after the snowpack season in predicting seasonal runoff in western Colorado. This question is critical because the most effective investment strategy for improving forecasts depends on if errors arise before or after the snowpack season. This study is conducted using observations from the Snow Telemetry Network, root zone soil moisture and groundwater data from the Western Land Data Assimilation Systems, and a random forest–based statistical forecasting framework. We find that on average, antecedent root zone soil moisture and groundwater storage values do not add significant skill to seasonal water supply forecasts in western Colorado. In contrast, using precipitation and temperature data after the time of peak snowpack improves water supply forecasts significantly. The 2020 and 2021 runoffs were hampered by dry conditions both before and after the snowpack season. Both antecedent soil moisture and spring/summer precipitation data improved water supply forecast accuracy in these years.

Significance Statement
Seasonal water supply forecasts in western Colorado are highly valuable because spring and summer runoff from this region helps support the water supply of 40 million people. Accurate forecasts improve the management of the region’s water. Heavy investments have been made in improving our ability to monitor antecedent hydrological conditions in western Colorado, such as root zone soil moisture and groundwater. However, results from this study indicate that the largest source of uncertainty in western Colorado runoff forecasts is future weather. Therefore, improved subseasonal-to-seasonal weather forecasts for western Colorado are what is most needed to improve regional water supply forecasts, and the ability to properly manage western Colorado water.
Care recipients’ management of and approaches to receiving personal and intimate care
Authors: Lövgren Veronica , Kalman Hildur , Andersson Katarina , Ahnlund Petra 
Published: September 2023

Summary An interview study was conducted with persons receiving home care services and personal assistance in Sweden (13 individuals, 25 interviews) with the aim to analyze their experiences of managing personal and intimate care. The analytical approach was guided by phenomenologically informed research and Erving Goffman's theoretical work on self-presentation and social life as it differs in frontstage and backstage settings. Findings A reflected approach to the complex challenges associated with becoming and being a person in need of personal and intimate care was revealed. This involved continuous adaptations and attuning to organizational and relational conditions of formal home care. Being a recipient of personal and intimate care does not mean being passive. It entails relating to and sustaining the care relation, where even choosing to accept suboptimal conditions is an act of agency. The recipients’ private homes were hybridized, transformed both into a waiting room, with the recipient on standby and into a workplace. The homes thus partly lost their character as a backstage realm where one could avoid the gaze of others. This also led to a hybridization of the personal sphere, in the form of marginal scope for true privacy, necessitating strategies for protecting one's own space. Applications It is important both to acknowledge the intrusive nature of personal and intimate care, which results in extensive hybridization of the home and personal sphere and to recognize care recipients’ agency in the relationship that care establishes.
Stroke Riskometer Application (SRA™) influence on lifestyle changes of home bound familial Malaysian stroke caregivers: a randomised controlled trial in a primary care based longer term stroke care facility
Authors: Hussin Radhiyah , Aziz Aznida Firzah Abdul , Ali Mohd Fairuz , Monoto Ezura Madiana Md , Arvinder-Singh HS , Alabed Alabed Ali Ahmed , Zaidi Wan Asyraf Wan , Ibrahim Norlinah Mohamed ,   FRCPE
Published: September 2023

Abstract
Background
In countries where access to Specialist stroke care services are limited, primary care physicians often manage stroke patients and the caregiving family members. This study aimed to evaluate the impact of Stroke Riskometer Application (SRA™) on promoting healthier lifestyles among familial stroke caregivers for primary prevention.

Methods
A parallel, open-label, 2-arm prospective, pilot randomised controlled trial was conducted at a long-term stroke service at a university based primary care clinic. All stroke caregivers aged ≥ 18 years, proficient in English or Malay and smartphone operation were invited. From 147 eligible caregivers, 76 participants were randomised to either SRA™ intervention or conventional care group (CCG) after receiving standard health counselling. The intervention group had additional SRA™ installed on their smartphones, which enabled self-monitoring of modifiable and non-modifiable stroke risk factors. The Stroke Riskometer app (SRATM) and Life's Simple 7 (LS7) questionnaires assessed stroke risk and lifestyle practices. Changes in clinical profile, lifestyle practices and calculated stroke risk were analysed at baseline and 3 months.
The trial was registered in the Australia-New Zealand Clinical Trial Registry, ACTRN12618002050235.

Results
The demographic and clinical characteristics of the intervention and control group study participants were comparable. Better improvement in LS7 scores were noted in the SRA™ arm compared to CCG at 3 months: Median difference (95% CI) = 0.88 (1.68–0.08), p = 0.03. However, both groups did not show significant changes in median stroke risk and relative risk scores at 5-, 10-years (Stroke risk 5-years: Median difference (95% CI) = 0.53 (0.15–1.21), p = 0.13, 10-years: Median difference (95% CI) = 0.81 (0.53–2.15), p = 0.23; Relative risk 5-years: Median difference (95% CI) = 0.84 (0.29–1.97), p = 0.14, Relative risk 10-years: Median difference (95% CI) = 0.58 (0.36–1.52), p = 0.23).

Conclusion
SRA™ is a useful tool for familial stroke caregivers to make lifestyle changes, although it did not reduce personal or relative stroke risk after 3 months usage.

Trial registration
No: ACTRN12618002050235 (Registration Date: 21st December 2018).
Utilization of preconception care and associated factors among pregnant women attending ANC in private MCH Hospitals in Addis Ababa, Ethiopia
Authors: Girma Addisu , Bedada Abera , Kumbi Solomon 
Published: September 2023

Abstract
Background
Despite its benefit in promoting maternal health and the health of her developing fetus, little is known about preconception care practice and its associated factors in Ethiopia. Moreover, preconception care utilization in private hospitals is not known. The purpose of this study, therefore, is to determine the utilization of preconception health care services and its associated factors among pregnant women following antenatal care in the private Maternal and Child Health hospitals in Addis Ababa.

Methods
A Hospital based cross-sectional study was conducted from April 1 to April 30,2022 among 385 women attending ANC in private MCH hospitals. Bestegah and Hemen MCH hospitals were selected by convenience method. Data were collected by a pretested self-administered semi-structured questionnaire. To identify the factors associated with the utilization of preconception care, bivariable and multivariable logistic regression analysis were performed. Adjusted odds ratios with 95% confidence interval were estimated to assess the strength of associations, and statistical significance was declared at a p-value < 0.05.

Results
The utilization of preconception care among the pregnant mothers according to our study was 40%. Professional/technical/managerial occupation (AOR = 4.3, 95%CI = 1.13, 16.33, P < 0.032), having good knowledge on preconception care (AOR = 3.5, 95%CI = 1.92, 6.53, P < 0.000), having unintended pregnancy (AOR = 0.1, 95%CI = 0.03, 0.42, P < 0.001), history of family planning use before conception (AOR = 3.9, 95%CI = 1.20, 12.60, P < 0.023), having pre-existing medical disease(s) (AOR = 8.4, 95%CI = 2.83, 24.74, P < 0.002), and having adverse pregnancy outcome(s) in previous pregnancies (AOR = 3.2, 95%CI = 1.55, 6.50, P < 0.000) were significantly associated with preconception care utilization.

Conclusions
This study found out that the utilization of preconception care in the private MCH hospitals is still low i.e., only 40%. Occupation, level of knowledge, having unintended pregnancy, history of family planning use before conception, having adverse pregnancy outcome(s) in previous pregnancy and having pre-existing medical disease(s) were independently associated with preconception care utilization. Lack of awareness about the availability of the services and having an unintended pregnancy were the main reasons for not utilizing preconception care.
Life expectancy and healthy life expectancy of Korean registered disabled by disability type in 2014–2018: Korea National Rehabilitation Center database
Authors: Jang Hyuna , Choi Kyung-Hwa , Kim Jung-Ae , Choi Yong-jun 
Published: September 2023

Abstract
Background
Conducting a distinct comparison between the life expectancy (LE) and healthy life expectancy (HALE) of people with disabilities (PWDs) and the general population is necessary due to the various environmental and health conditions they encounter. Therefore, this study aimed to develop the life table for PWDs and calculate those of LE and HALE based on sex, severity, and disability types among the registered Korean PWDs.

Methods
We used aggregated data of registered PWDs from the Korea National Rehabilitation Center database between 2014 and 2018. Overall, 345,595 deaths were included among 12,627,428 registered PWDs. First, we calculated the LE for total PWDs and non-disabled people using a standard life table, extending the old age mortality among nine models. Subsequently, we calculated the LE for each type of disability using the relationship between the mortality of total PWDs and those of each type of disability. Finally, HALE was calculated using the Sullivan method for three types as follows: disability-free and perceived health (PH) using the National Survey, and hospitalized for  ≥ 7 days using the Korea National Health Insurance System (NHIS) database.

Results
The calculated LE/HALE–NHIS (years) at registration in males and females were 81.32/73.32 and 87.38/75.58, 68.54/58.98 and 71.43/59.24, 73.87/65.43 and 78.25/67.51, and 61.53/50.48 and 62.41/49.72 years among non-disabled, total PWDs, mild disabled, and severe disabled, respectively. LE/HALE-NHIS was lowest and highest in respiratory dysfunction and hearing disabilities, respectively.

Conclusions
Males with disabilities had shorter LE and HALE at registration than females, except for those with severe disabilities, and there were variabilities in the LE based on the disability types.
A cytodiagnosis of adenoid cystic carcinoma of the tracheobronchial tree through a systematic clinical case comparison and analysis
Authors: Zhou Bing , Duan Ting , Liu Xianwei , Peng Lizi 
Published: September 2023

Abstract
Background
Primary adenoid cystic carcinoma (AdCC) of the tracheobronchial tree is very rare with a high risk for recurrence and metastasis. The diagnosis of AdCC by histologic and immunohistochemical means has been well studied clinically. However, the identification of AdCC by cytologic features remains elusive due to the atypical features the cancer presents. This study aimed to describe the cytologic features of AdCC by using bronchial brushing, which could aid in distinguishing AdCC from other pulmonary carcinomas.

Methods
The cytopathological features of bronchial brushing smears collected from seven cases were histologically diagnosed as AdCC. The defined cytologic features, which could potentially be diagnostic, were systemically analyzed.

Results
Four out of the seven cytologic cases were inconcordance with the histologic diagnosis and cytologically classified as positive for malignant cells, small cell carcinoma, or atypical cells. Three cases showed a characteristic adenoid structure and magenta stroma forming globule, which was distinguished from the four cases. Cytologically, the above mentioned three cases were uniform with relatively small bland nuclei and little cytoplasm. In this study, only one case showed atypical polygonal medium-sized cells with conspicuous nucleoli.

Conclusions
Unlike fine-needle aspiration cytology, magenta stroma globules might offer an alternate clue for cytodiagnosis of AdCC clinically. Bronchial brushings cytology was more present in bland uniform cells with high nuclear to cytoplasmic ratios and background mucoid substance. More cases should be collected and confirmed using histopathology with careful film reading to reduce the rate of misdiagnosis.
Effects of three spontaneous ventilation modes on respiratory drive and muscle effort in COVID-19 pneumonia patients
Authors: Simón José Manuel Serrano , Montosa Carolina Joya , Carmona Juan Francisco Martínez , Amaya Manuel Jesús Delgado , Castro Javier Luna , Carmona Ashlen Rodríguez , Pérez José Castaño , Delgado Marina Rodríguez , Centeno Guillermo Besso , Lozano José Antonio Benítez 
Published: September 2023

Abstract
Background
High drive and high effort during spontaneous breathing can generate patient self-inflicted lung injury (P-SILI) due to uncontrolled high transpulmonary and transvascular pressures, with deterioration of respiratory failure. P-SILI has been demonstrated in experimental studies and supported in recent computational models. Different treatment strategies have been proposed according to the phenotype of elastance of the respiratory system (Ers) for patients with COVID-19. This study aimed to investigate the effect of three spontaneous ventilation modes on respiratory drive and muscle effort in clinical practice and their relationship with different phenotypes. This was achieved by obtaining the following respiratory signals: airway pressure (Paw), flow (V´) and volume (V) and calculating muscle pressure (Pmus).

Methods
A physiologic observational study of a series of cases in a university medical-surgical ICU involving 11 mechanically ventilated patients with COVID-19 pneumonia at the initiation of spontaneous breathing was conducted. Three spontaneous ventilation modes were evaluated in each of the patients: pressure support ventilation (PSV), airway pressure release ventilation (APRV), and BiLevel positive airway pressure ventilation (BIPAP). Pmus was calculated through the equation of motion. For this purpose, we acquired the signals of Paw, V´ and V directly from the data transmission protocol of the ventilator (Dräger). The main physiological measurements were calculation of the respiratory drive (P0.1), muscle effort through the ΔPmus, pressure‒time product (PTP/min) and work of breathing of the patient in joules multiplied by respiratory frequency (WOBp, J/min).

Results
Ten mechanically ventilated patients with COVID-19 pneumonia at the initiation of spontaneous breathing were evaluated. Our results showed similar high drive and muscle effort in each of the spontaneous ventilatory modes tested, without significant differences between them: median (IQR): P0.1 6.28 (4.92–7.44) cm H2O, ∆Pmus 13.48 (11.09–17.81) cm H2O, PTP 166.29 (124.02–253.33) cm H2O*sec/min, and WOBp 12.76 (7.46–18.04) J/min. High drive and effort were found in patients even with low Ers. There was a significant relationship between respiratory drive and WOBp and Ers, though the coefficient of variation widely varied.

Conclusions
In our study, none of the spontaneous ventilatory methods tested succeeded in reducing high respiratory drive or muscle effort, regardless of the Ers, with subsequent risk of P-SILI.
A participatory ergonomics intervention to re-design work and improve the musculoskeletal health of paramedics: protocol for a cluster randomised controlled trial
Authors: Davies Karen , Weale Victoria , Oakman Jodi 
Published: September 2023

Abstract
Background
In this paper, we present the protocol for a cluster randomised controlled trial to evaluate the effectiveness and implementation of a participative risk management intervention to address work-related musculoskeletal disorders (WMSDs). The aims of the study include to evaluate the implementation process and the impact of the intervention on work related musculoskeletal pain and discomfort and exposure to physical and psychosocial hazards in paramedics over a 12-month period.

Methods
The intervention in this study is to implement A Participative Hazard Identification and Risk Management (APHIRM) toolkit in an ambulance service. Eighteen work groups containing eligible participants (registered paramedics) will be randomised into the intervention or wait-list control arm in one of three rolling recruitment periods. The APHIRM toolkit survey will be offered at baseline and 12 months later, to all current eligible participants in each work group allocated to the trial. The intervention work groups will receive the remainder of the APHIRM toolkit procedures. Identifying data about individual participants will not be collected in the survey, to protect participant privacy and encourage participation. Changes in primary (musculoskeletal pain and discomfort) and secondary (exposure to physical and psychosocial hazards at work) outcomes measured in the survey will be analysed comparing the baseline and follow up response of the cluster. A process evaluation is included to analyse the implementation and associated barriers or facilitators.

Discussion
This study is important in providing a comprehensive approach which focusses on both physical and psychosocial hazards using worker participation, to address WMSDs, a well-known and significant problem for ambulance services. The effectiveness of the intervention in work groups will be rigorously evaluated. If significant positive results are observed, the intervention may be adopted in ambulance services, both nationally and internationally.

Trial registration
ISRCTN77150219. Registered 21 November 2021.