bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pemecahan Saham Terhadap Likuiditas Saham Dengan Price Earning Ratio Sebagai Variabel Moderasi
Authors: Leluni Hana Christianty 
Published: August 2023

Tujuan penelitian ini yaitu untuk mengetahui pengaruh pemecahan saham terhadap likuiditas saham dengan price earning ratio sebagai variabel moderasi (studi pada perusahaan yang terdaftar di BEI tahun 2019-2021). Penelitian ini menggunakan jenis penelitian kuantitatif dengan menggunakan metode purposive sampling untuk pemilihan sampel penelitian. Jumlah sampel yang digunakan yaitu sebanyak 31 perusahaan. Data yang diperoleh menggunakan sumber data sekunder yang diperoleh dari webside www.idx.co.id. Teknik analisis yang digunakan dalam penelitian ini yaitu menggunakan uji t dan moderated regression analysis untuk variabel moderasi. Berdasarkan hasil penelitian ini menunjukkan bahwa terdapat pengaruh positif signifikan pemecahan saham terhadap likuiditas saham, hal tersebut ditunjukkan oleh hasil uji hipotesis yang diperoleh karena t hitung 1,819 < t tabel 1,06390 dengan nilai signifikansi 0,016 < 0,05. Price earning ratio secara tidak dapat memperkuat pengaruh pemecahan saham terhadap likuiditas saham. Hasil uji koefisien determinansi menunjukkan bahwa variabel independen, variabel moderasi dan interaksi kedua variabel tersebut hanya mampu menjelaskan 10,7% selebihnya 89,3% dijelaskan oleh variabel lain.
Kata Kunci : pemecahan saham, price earning ratio, likuiditas saham
Dispositivo de monitoreo para pacientes con crisis epilépticas de tipo tónico-clónico
Authors: Alvarado Pereda Diana Melisa , Ibáñez Nangüelú Christian Roberto , Domínguez Pérez Obdulia Jocabed , Vazquez López Norberto , Villarreal  Madelin Gaspar 
Published: August 2023

La epilepsia es una enfermedad crónica del sistema nervioso central (SNC) con diversidad de presentaciones Una crisis convulsiva (CC) es un evento autolimitado, de origen cerebral, que resulta de la descarga anormal y excesiva de una población neuronal, con manifestaciones clínicas variadas, de inicio y finalización generalmente súbitos(Eslava, 2006). Con el objetivo de proporcionar un monitoreo efectivo para pacientes diagnosticados con crisis epilépticas tónico-clónico, se ha desarrollado un dispositivo especializado en la detección de parámetros fisiológicos como el pulso cardíaco, la temperatura y la posición del paciente. Además, cuenta con un sensor que detecta la actividad muscular en el bíceps braquial. El dispositivo está diseñado específicamente para este tipo de padecimiento. Las crisis epilépticas tónico-clónicas se manifiestan inicialmente con un aumento de tono muscular y sacudidas rítmicas de las extremidades, y duran unos pocos minutos (CDC,2020). Cuando los parámetros fisiológicos medidos están fuera del rango permitido por los sensores, el dispositivo emitirá una alerta visual, indicando el inicio de una crisis epiléptica. En ese momento, se enviará una notificación a un familiar o cuidador del paciente, para brindar la asistencia necesaria. Se espera que el dispositivo ayude a que la atención sea más precisa y personalizada, mejorando la calidad de vida y brindando mayor tranquilidad al paciente, su entorno familiar y cuidadores.
La andragogía en la enseñanza del turismo en instituciones superiores
Authors: Urgiles Alvarez Miguel Patricio 
Published: August 2023

La implementación de la andragogía en institutos de educación superior ha resultado valiosa para mejorar el aprendizaje de estudiantes adultos, especialmente en las carreras de turismo de los Institutos de educación superior y uniiversidades con estrategias como la enseñanza basada en problemas y por proyectos. Estudios internacionales, ecuatorianos y locales han demostrado que esta metodología incrementa la motivación y el desempeño académico de los estudiantes adultos. La andragogía reconoce las necesidades y características de los estudiantes adultos, promoviendo un aprendizaje más significativo y relevante, adaptado a sus experiencias previas y fomentando su desarrollo personal y profesional. En este estudio se realizó una revisión documental, también conocida como revisión bibliográfica, para recopilar información objetiva y científica relacionada con la problemática investigada. La revisión bibliográfica constó de cuatro fases: planificación, búsqueda, selección y redacción de la información.Se establecieron criterios de inclusión y exclusión para seleccionar los textos adecuados. Finalmente, La andragogía enfatiza el aprendizaje autónomo y el desarrollo continuo, adaptando estrategias didácticas que permiten a los estudiantes aplicar conocimientos previos en situaciones reales. Además, se destaca la importancia de la capacitación docente en los principios andragógicos, el fomento de una cultura de aprendizaje continuo y el uso de evaluaciones formativas y auténticas basadas en habilidades relevantes.
Methanol Formation through Reaction of Low-energy CH3
+ Ions with an Amorphous Solid Water Surface at Low Temperature
Authors: Nakai Y. , Sameera W. M. C. , Furuya K. , Hidaka H. , Ishibashi A. , Watanabe N. 
Published: August 2023

Abstract
We have performed experimental investigations of methanol formation via the reactions of low-energy CH3
+ ions with an amorphous solid water (ASW) surface at ∼10 K. A newly developed experimental apparatus enabled irradiation of the ASW surface by several eV ions and detection of trace amounts of reaction products on the surface. It was found that methanol molecules were produced by low-energy CH3
+ irradiation of the ASW surface and that hydroxy groups in the produced methanol originated from water molecules in the ASW, as predicted in a previous theoretical study. Little temperature dependence of the observed methanol intensity is apparent in the temperature range 12–60 K. Ab initio molecular dynamics simulations under constant-temperature conditions of 10 K suggested that this reaction spontaneously produced a methanol molecule and an H3O+ ion, regardless of the contact point of CH3
+ on the ASW surface. We have performed a simulation with an astrochemical model under molecular-cloud conditions, where the reaction between CH3
+ and H2O ice, leading to methanol formation, was included. We found that the impact of the reaction on methanol abundance was limited only at the edge of the molecular cloud (<1 mag) because of the low abundance of CH3
+ in the gas phase, whereas the reaction between the abundant molecular ion (HCO+) and H2O ice, which has not yet been confirmed experimentally, can considerably affect the abundance of a complex organic molecule. This work sheds light on a new type of reaction between molecular ions and ice surfaces that should be included in astrochemical models.
Comparing Energetic Storm Particle Heavy-ion Properties in Solar Cycles 23 and 24
Authors: Santa Fe Dueñas A. , Ebert R. W. , Dayeh M. A. , Desai M. I. , Jian L. K. , Li G. 
Published: August 2023

Abstract
We examine variations in energetic storm particle (ESP) heavy-ion average intensities and energy spectra between ∼0.1 and 75 MeV nucleon−1 at coronal mass ejection (CME)–driven interplanetary shocks for events observed at the ACE spacecraft. We compare ESP events observed during the weaker solar cycle (SC) 24 and the relatively stronger SC 23 to investigate any effects on the strength of an SC, including the associated transient events, on ESP properties at 1 au. We find that the number of clearly defined heavy-ion ESP events at ACE during SC 23 is about twice that observed during SC 24 (76 versus 41). The average transit speed of the driving interplanetary CMEs (ICMEs) at 1 au is 20% higher during SC 23 than during SC 24 (859.4 km s−1 versus 729.1 km s−1). The correlation of ESP average intensities with ICME speeds shows that lower-speed ICMEs in SC 24 can be as efficient as the higher-speed events in SC 23 at producing ESPs below 2 MeV nucleon−1. The distribution and magnitude of the average intensities for energies below ∼1 MeV nucleon−1 are consistent between both SCs. However, events with intensity enhancements at higher energies (>∼10 MeV nucleon−1) are more frequent and their intensity distributions are harder for SC 23, resulting in an increase in the rollover energy (E
0) for their spectra profiles. This suggests more efficient ESP acceleration at >10 MeV nucleon−1 during SC 23.
Data-constrained 3D Modeling of a Solar Flare Evolution: Acceleration, Transport, Heating, and Energy Budget
Authors: Fleishman Gregory D. , Nita Gelu M. , Motorina Galina G. 
Published: August 2023

Abstract
Solar flares are driven by the release of free magnetic energy and its conversion to other forms of energy—kinetic, thermal, and nonthermal. Quantification of partitions between these energy components and their evolution is needed to understand the solar flare phenomenon including nonthermal particle acceleration, transport, and escape as well as the thermal plasma heating and cooling. The challenge of remote-sensing diagnostics is that the data are taken with finite spatial resolution and suffer from line-of-sight (LOS) ambiguity including cases when different flaring loops overlap and project one over the other. Here, we address this challenge by devising a data-constrained evolving 3D model of a multiloop SOL2014-02-16T064620 solar flare of GOES class C1.5. Specifically, we employed a 3D magnetic model validated earlier for a single time frame and extended it to cover the entire flare evolution. For each time frame we adjusted the distributions of the thermal plasma and nonthermal electrons in the model so that the observables synthesized from the model matched the observations. Once the evolving model had been validated in this way, we computed and investigated the evolving energy components and other relevant parameters by integrating over the model volume. This approach removes the LOS ambiguity and permits us to disentangle contributions from the overlapping loops. It reveals new facets of electron acceleration and transport as well as of the heating and cooling of the flare plasma in 3D. We find signatures of substantial direct heating of the flare plasma not associated with the energy loss of nonthermal electrons.
A Type II Radio Burst Driven by a Blowout Jet on the Sun
Authors: Hou Zhenyong , Tian Hui , Su Wei , Madjarska Maria S. , Chen Hechao , Zheng Ruisheng , Bai Xianyong , Deng Yuanyong 
Published: August 2023

Abstract
Type II radio bursts are often associated with coronal shocks that are typically driven by coronal mass ejections (CMEs) from the Sun. Here we conduct a case study of a type II radio burst that is associated with a C4.5-class flare and a blowout jet, but without the presence of a CME. The blowout jet is observed near the solar disk center in the extreme-ultraviolet (EUV) passbands with different characteristic temperatures. Its evolution involves an initial phase and an ejection phase with a velocity of 560 ± 87 km s−1. Ahead of the jet front, an EUV wave propagates at a projected velocity of ∼403 ± 84 km s−1 in the initial stage. The velocity of the type II radio burst is estimated to be ∼641 km s−1, which corresponds to the shock velocity against the coronal density gradient. The EUV wave and the type II radio burst are closely related to the ejection of the blowout jet, suggesting that both are likely the manifestation of a coronal shock driven by the ejection of the blowout jet. The type II radio burst likely starts lower than those associated with CMEs. The combination of the velocities of the radio burst and the EUV wave yields a modified shock velocity at ∼757 km s−1. The Alfvén Mach number is in the range of 1.09–1.18, implying that the shock velocity is 10%–20% larger than the local Alfvén velocity.
Brown Dwarf Retrievals on FIRE!: Atmospheric Constraints and Lessons Learned from High Signal-to-noise Medium-resolution Spectroscopy of a T9 Dwarf
Authors: Hood Callie E. , Fortney Jonathan J. , Line Michael R. , Faherty Jacqueline K. 
Published: August 2023

Abstract
Brown dwarf spectra offer vital testbeds for our understanding of the chemical and physical processes that sculpt substellar atmospheres. Recently, atmospheric retrieval approaches have been successfully applied to low-resolution (R ∼ 100) spectra of L, T, and Y dwarfs, yielding constraints on the chemical abundances and temperature structures of these atmospheres. Medium-resolution (R ∼ 103) spectra of brown dwarfs offer additional insight, as molecular features are more easily disentangled and the thermal structure of the upper atmosphere is better probed. We present results from a GPU-based retrieval analysis of a high signal-to-noise, medium-resolution (R ∼ 6000) FIRE spectrum from 0.85 to 2.5 μm of the T9 dwarf UGPS J072227.51–054031.2. At 60× higher spectral resolution than previous brown dwarf retrievals, a number of novel challenges arise. We examine the effect of different opacity sources, in particular for CH4. Furthermore, we find that flaws in the data like errors from order stitching can bias our constraints. We compare these retrieval results to those for an R ∼ 100 spectrum of the same object, revealing how constraints on atmospheric abundances and temperatures improve by an order of magnitude or more with increased spectral resolution. In particular, we can constrain the abundance of H2S, which is undetectable at lower spectral resolution. While these medium-resolution retrievals offer the potential of precise, stellar-like constraints on atmospheric abundances (∼0.02 dex), our retrieved radius is unphysically small (

R
=

0.50

−
0.01

+
0.01

R
Jup), indicating shortcomings with our modeling framework. This work is an initial investigation into brown dwarf retrievals at medium spectral resolution, offering guidance for future ground-based studies and JWST observations.
The Mass Fractionation of Helium in the Escaping Atmosphere of HD 209458b*
Authors: Xing 邢 Lei 磊 , Yan 闫 Dongdong 冬冬 , Guo 郭 Jianheng 建恒 
Published: August 2023

Abstract
The absorption signals of metastable He in HD 209458b and several other exoplanets can be explained via an escaping atmosphere model with a subsolar He/H ratio. The low abundance of helium can be a result of planet formation if there is a small amount of helium in their primordial atmosphere. However, another possibility is that the low He/H ratio is caused by the process of mass fractionation of helium in the atmosphere. In order to investigate the effect of fractionation in the hydrogen-helium atmosphere, we developed a self-consistent multi-fluid 1D hydrodynamic model based on the well-known open-source MHD code PLUTO. Our simulations show that a lower He/H ratio can be produced spontaneously in the multi-fluid model. We further modeled the transmission spectra of He 10830 lines for HD 209458b in a broad parameter space. The transmission spectrum of the observation can be fitted in the condition of 1.80 times the X-ray and extreme-ultraviolet flux of the quiet Sun. Meanwhile, the ratio of the escaping flux of helium to hydrogen, F
He/F
H, is 0.039. Our results indicate that the mass fractionation of helium to hydrogen can naturally interpret the low He/H ratio required by the observation. Thus, in the escaping atmosphere of HD 209458b, decreasing the abundance of helium in the atmosphere is not needed even if its He abundance is similar to that of the Sun. The simulation presented in this work hints that in the escaping atmosphere, mass fractionation can also occur on other exoplanets, which needs to be explored further.
Temporal Evolution of Titan’s Stratospheric Temperatures and Trace Gases from a Two-dimensional Retrieval of Cassini Composite Infrared Spectrometer Data
Authors: Achterberg Richard K. 
Published: August 2023

Abstract
We use a two-dimensional (2D) radiative transfer model of Titan, which allows the atmospheric structure to vary in both altitude and latitude, to retrieve the spatial distribution of temperature, haze extinction, and C2H2, C2H6, C3H8, CH3C2H, C4H2, and HCN gases, from Cassini Composite Infrared Spectrometer (CIRS) limb-mapping observations over the duration of the Cassini mission. We compare our results with previous analyses of CIRS limb observations using radiative models that only allow the atmosphere to vary in altitude. The temperature, haze, and gas composition retrieved with the 2D model mostly show the same broad spatial and temporal trends as previously published results from 1D models. However, there are some significant differences in the retrieved structure at the fall and winter poles poleward of 60°. Most noticeably, the HCN abundance in the depleted region near 65°N at 350 km in northern winter is stronger in the 2D retrievals than in previous 1D retrievals, and the 2D retrievals show very different structure from earlier 1D retrievals in the north polar C2H2 structure during early northern spring, with a strong depletion around 70°N at 0.02 mbar.
The role of Mas receptor on renal hemodynamic responses to angiotensin II administration in chronic renal sympathectomized male and female rats
Authors: Hosseini-Dastgerdi Hajaralsadat , Pourshanazari Ali-Asghar , Nematbakhsh Mehdi 
Published: August 2023

Background and purpose:
Renal hemodynamics is influenced by renal sympathetic nerves and the renin-angiotensin system. On the other hand, renal sympathetic denervation impacts kidney weight by affecting renal hemodynamics. The current study evaluated the role of the Mas receptor on renal hemodynamic responses under basal conditions and in response to angiotensin II (Ang II) in chronic renal sympathectomy in female and male rats.

Experimental approach:
Forty-eight nephrectomized female and male rats were anesthetized and cannulated. Afterward, the effect of chronic renal sympathectomy was investigated on hemodynamic parameters such as renal vascular resistance (RVR), mean arterial pressure (MAP), and renal blood flow (RBF). In addition, the effect of chronic sympathectomy on kidney weight was examined.

Findings/Results:
Chronic renal sympathectomy increased RVR and subsequently decreased RBF in both sexes. Renal perfusion pressure also increased after sympathectomy in male and female rats, while MAP did not change, significantly. In response to the Ang II injection, renal sympathectomy caused a greater decrease in RBF in all experimental groups, while it did not affect the MAP response. In addition, chronic sympathectomy increased left kidney weight in right nephrectomized rats.

Conclusion and implications:
Chronic renal sympathectomy changed systemic/renal hemodynamics in baseline conditions and only renal hemodynamics in response to Ang II administration. Moreover, chronic sympathectomy increased compensatory hypertrophy in nephrectomized rats. These changes are unaffected by gender difference and Mas receptor blocker.
A novel approach to enhance the performance of kallikrein 6 enzyme using Pichia pastoris GS115 as a host
Authors: Mahmoodi Fatemeh , Bakherad Hamid , Mogharrab Navid , Rabbani Mohammad 
Published: August 2023

Background and purpose:
Enzyme engineering is the process of raising enzyme efficiency and activity by altering amino acid sequences. Kallikrein 6 (KLK6) enzyme is a secreted serine protease involved in a variety of physiological and pathological activities. The increased expression of KLK6 plays a key role in various diseases. Instability and spontaneous activation and deactivation are major challenges in the study of this enzyme. This study aimed to create a stable pro-KLK6 enzyme by enzyme engineering, designing a specific cleavage site for enterokinase, and using Pichia pastoris GS115 as a host cell. Then, recombinant pro-KLK6 was used to introduce a novel inhibitor for it.

Experimental approach:
An engineered pro-KLK6 gene was cloned into the pPICZα A expression vector. Then, it was expressed in P. pastoris GS115 and purified by Ni-NTA chromatography. An inactive engineered pro-KLK6 gene was cleaved by enterokinase and converted to an active KLK6. The KLK6 enzyme activity and its kinetic parameters were measured using N-benzoyl-L-arginine ethyl ester (BAEE) substrates.

Findings/Results:
The secretory form of the pro-KLK6 was expressed at about 11 mg/L in P. pastoris (GS115). Before activation with enterokinase, pro-KLK6 was inactive and did not activate spontaneously. The kinetic parameters, including Km and Vmax, were estimated at 113.59 μM and 0.432 μM/s, respectively.

Conclusion and implications:
A stable pro-KLK6 enzyme was produced using P. pastoris (GS115) as the host cell and a specific cleavage site for enterokinase. Additionally, this study assessed the kinetic parameters of the KLK6 enzyme using the BAEE substrate for the first time.
PCL/Agarose 3D-printed scaffold for tissue engineering applications: fabrication, characterization, and cellular activities
Authors: Ghaedamini Sho'leh , Karbasi Saeed , Hashemibeni Batool , Honarvar Ali , Rabiei Abbasali 
Published: August 2023

Background and purpose:
Biomaterials, scaffold manufacturing, and design strategies with acceptable mechanical properties are the most critical challenges facing tissue engineering.

Experimental approach:
In this study, polycaprolactone (PCL) scaffolds were fabricated through a novel three-dimensional (3D) printing method. The PCL scaffolds were then coated with 2% agarose (Ag) hydrogel. The 3D-printed PCL and PCL/Ag scaffolds were characterized for their mechanical properties, porosity, hydrophilicity, and water absorption. The construction and morphology of the printed scaffolds were evaluated via Fourier-Transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The attachment and proliferation of L929 cells cultured on the scaffolds were investigated through MTT assay on the cell culture study upon the 1st, 3rd, and 7th days.

Findings/Results:
The incorporation of Ag hydrogel with PCL insignificantly decreased the mechanical strength of the scaffold. The presence of Ag enhanced the hydrophilicity and water absorption of the scaffolds, which could positively influence their cell behavior compared to the PCL scaffolds. Regarding cell morphology, the cells on the PCL scaffolds had a more rounded shape and less cell spreading, representing poor cell attachment and cell-scaffold interaction due to the hydrophobic nature of PCL. Conversely, the cells on the PCL/Ag scaffolds were elongated with a spindle-shaped morphology indicating a positive cell-scaffold interaction.

Conclusion and implications:
PCL/Ag scaffolds can be considered appropriate for tissue-engineering applications.