bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panentheism as cosmopolitanism: Karl Christian Friedrich Krause's conception of a global human league
Authors: Göcke Benedikt Paul 
Published: January 2023

AbstractKarl Christian Friedrich Krause (1781–1832) left for posterity an impressive and astonishingly contemporarycorpusof philosophical creativity. Not only does it cover numerous topics of theoretical and practical philosophy, from a panentheistic-cosmopolitan point of view, but, in terms of the history of philosophy, it may be seen as one of the first works from a European pen which also appreciates the Indian roots of European thinking in their systematic importance. It combines them with Platonic metaphysics and Kant's transcendental philosophy to form a system of philosophy that is truly intercultural. In what follows, Krause's fundamental argument for panentheism is presented before it is argued that Krause's panentheism entails a cosmopolitan theory of human society according to which it is a postulate of practical reason to realize a cosmopolitan global league of humanity.
When prayer goes wrong: A negative theology of prayer
Authors: Cocksworth Ashley 
Published: January 2023

AbstractPrayer is often taken to be the solution to all manner of things. But what happens when prayer is not so much the solution to the injustices of the world as part of the problem? In this article, I present Karl Barth's idea of the ‘shadow-side’ of creation as a way of querying the prayer-as-the-solution-to-everything trope and encouraging more disciplined thinking about prayer – one that is self-critical, alert to and realistic about the dangers of prayer and yet not without hope in the promise of prayer's remaking. I call this way of thinking about prayer a ‘negative’ theology of prayer.
Who should work in Antarctica? An exploration of the individual, social and cultural aspects of expeditioner recruitment
Authors: Nash Meredith 
Published: January 2023

AbstractDrawing on qualitative interview data, this article explores past and current Australian Antarctic Program expeditioners' perceptions of the personal qualities of expeditioners alongside their views of Antarctic station culture and expeditioner recruitment procedures. The findings reveal study participants shared similar views about expeditioner personal qualities. However, the findings also suggest that the current demographic similarity of expeditioners (e.g. the overrepresentation of white men) is perhaps much more important for assessing organizational fit than the Program might be selecting for. Participants described the ways in which interpersonal interactions and the social environment can deeply affect an expeditioner's experience of the station culture. Women in this study pointed to the connection between the overrepresentation of men in the expeditioner population and a potential male bias in station culture. These results extend the existing literature on person-culture fit in Antarctica. To conclude, I provide recommendations for diversifying the expeditioner applicant pool in Antarctica that can also be applied to the selection of other workforces in isolated, confined and extreme work environments, including space missions.
Sound‐Side Inundation and Seaward Erosion of a Barrier Island During Hurricane Landfall
Authors: Sherwood Christopher R. , Ritchie Andrew C. , Over Jin‐Si R. , Kranenburg Christine J. , Warrick Jonathan A. , Brown Jenna A. , Wright C. Wayne , Aretxabaleta Alfredo L. , Zeigler Sara L. , Wernette Phillipe A. , Buscombe Daniel D. , Hegermiller Christie A. 
Published: January 2023

AbstractBarrier islands are especially vulnerable to hurricanes and other large storms, owing to their mobile composition, low elevations, and detachment from the mainland. Conceptual models of barrier‐island evolution emphasize ocean‐side processes that drive landward migration through overwash, inlet migration, and aeolian transport. In contrast, we found that the impact of Hurricane Dorian (2019) on North Core Banks, a 36‐km barrier island on the Outer Banks of North Carolina, was primarily driven by inundation of the island from Pamlico Sound, as evidenced by storm‐surge model results and observations of high‐water marks and wrack lines. Analysis of photogrammetry products from aerial imagery collected before and after the storm indicate the loss of about 18% of the subaerial volume of the island through the formation of over 80 erosional washout channels extending from the marsh and washover platform, through gaps in the foredunes, to the shoreline. The washout channels were largely co‐located with washover fans deposited by earlier events. Net seaward export of sediment resulted in the formation of deltaic bars offshore of the channels, which became part of the post‐storm berm recovery by onshore bar migration and partial filling of the washouts with washover deposits within 2 months. This event represents a volumetric setback in the overwash/rollover behavior required for barrier transgression, but the new ponds and lowland habitats may provide beneficial habit for endangered species and will likely persist for years.
Last Glacial Maximum Reconstructions of Rwenzori Mountain Glaciers
Authors: Doughty Alice M. , Kelly Meredith A. , Russell James M. , Jackson Margaret S. , Anderson Brian M. , Chipman Jonathan , Nakileza Bob R. 
Published: January 2023

AbstractThe magnitude of tropical cooling during the Last Glacial Maximum (LGM; ∼19–26.5 ka) remains controversial, with sea‐surface temperatures cooling by several degrees less than most temperatures reconstructed at high elevations. To explain this discrepancy, past studies proposed a steeper (increased) lapse rate—the temperature decrease with elevation—during the LGM relative to today. For instance, LGM temperatures in East Africa reconstructed from branched GDGTs from multiple elevations support an ∼0.9°C/km increase in the lapse rate during the LGM relative to present day. Lapse rates are a critical part of the Earth's climate sensitivity and atmospheric energy transfer, and it is vital to know whether and by how much the tropical lapse rate steepened during the LGM. Here, we simulate LGM glacier extents in the Rwenzori Mountains of Uganda with and without a change in lapse rate using a range of temperature and precipitation estimates. We find that the lapse rate must have been steeper than present for glaciers to reach their LGM positions using available sea‐level temperature and precipitation estimates for East Africa.
PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer
Authors: Garlapati Chakravarthy , Joshi Shriya , Bhattarai Shristi , Krishnamurthy Jayashree , Turaga Ravi Chakra , Nguyen Thi , Li Xiaoxian , Aneja Ritu 
Published: January 2023

AbstractProtein diversity due to alternative mRNA splicing or post-translational modifications (PTMs) plays a vital role in various cellular functions. The mitotic kinases polo-like kinase 1 (PLK1) and Aurora B (AURKB) phosphorylate survivin, an inhibitor of apoptosis (IAP) family member, thereby regulating cell proliferation. PLK1, AURKB, and survivin are overexpressed in triple-negative breast cancer (TNBC), an aggressive breast cancer subtype. TNBC is associated with high proliferative capacity, high rates of distant metastasis, and treatment resistance. The proliferation-promoting protein survivin and its activating kinases, PLK1 and AURKB, are overexpressed in TNBC. In this study, we investigated the role of survivin phosphorylation in racial disparities in TNBC cell proliferation. Analysis of TCGA TNBC data revealed higher expression levels of PLK1 (P = 0.026) and AURKB (P = 0.045) in African Americans (AAs; n = 41) than in European Americans (EAs; n = 86). In contrast, no significant racial differences in survivin mRNA or protein levels were observed. AA TNBC cells exhibited higher p-survivin levels than EA TNBC cells. Survivin silencing using small interfering RNAs significantly attenuated cell proliferation and cell cycle progression in AA TNBC cells, but not in EA TNBC cells. In addition, PLK1 and AURKB inhibition with volasertib and barasertib significantly inhibited the growth of AA TNBC xenografts, but not of EA TNBC tumors. These data suggest that inhibition of PLK1 and AURKB suppresses cell proliferation and tumor growth, specifically in AA TNBC. These findings suggest that targeting survivin phosphorylation may be a viable therapeutic option for AA patients with TNBC.
New approaches to epidemic modeling on networks
Authors: Gómez Arturo , Oliveira Gonçalo 
Published: January 2023

AbstractIn this article, we develop two independent and new approaches to model epidemic spread in a network. Contrary to the most studied models, those developed here allow for contacts with different probabilities of transmitting the disease (transmissibilities). We then examine each of these models using some mean field type approximations. The first model looks at the late-stage effects of an epidemic outbreak and allows for the computation of the probability that a given vertex was infected. This computation is based on a mean field approximation and only depends on the number of contacts and their transmissibilities. This approach shares many similarities with percolation models in networks. The second model we develop is a dynamic model which we analyze using a mean field approximation which highly reduces the dimensionality of the system. In particular, the original system which individually analyses each vertex of the network is reduced to one with as many equations as different transmissibilities. Perhaps the greatest contribution of this article is the observation that, in both these models, the existence and size of an epidemic outbreak are linked to the properties of a matrix which we call the$${\mathcal {R}}$$R-matrix. This is a generalization of the basic reproduction number which more precisely characterizes the main routes of infection.
Grassland versus forest dwelling rodents as indicators of environmental contamination with the zoonotic nematode Toxocara spp.
Authors: Krupińska Martyna , Antolová Daniela , Tołkacz Katarzyna , Szczepaniak Klaudiusz , Strachecka Aneta , Goll Aleksander , Nowicka Joanna , Baranowicz Karolina , Bajer Anna , Behnke Jerzy M. , Grzybek Maciej 
Published: January 2023

AbstractSmall mammals are suspected of contributing to the dissemination ofToxocara canisand helping with the parasite survival during periods when there is a temporary absence of suitable definitive hosts. While the primary aim of the current study was the assessment of seroprevalence ofToxocaraspp. infections in wild rodents in Poland, we also explored the role of intrinsic (sex, age) and extrinsic factors (study site) influencing dynamics of this infection to ascertain whether grassland versus forest rodents play a greater role as indicators of environmental contamination withT. canis. We trapped 577 rodents belonging to four species (Myodes glareolus, Microtus arvalis, Microtus agrestis, Alexandromys oeconomus) in north-eastern Poland. Blood was collected during the parasitological examination, and serum was frozen at − 80 °C until further analyses. A bespoke enzyme-linked immunosorbent assay was used to detect antibodies againstToxocaraspp.We foundToxocaraspp.antibodies in the sera of all four rodent species with an overall seroprevalence of 2.8% [1.9–4.1%]. There was a significant difference in seroprevalence between vole species, with the grassland species (M. arvalis, M. agrestisand A. oeconomus) showing a 16-fold higher seroprevalence (15.7% [8.7–25.9%]) than the forest-dwellingM. glareolus (0.98% [0.5–1.8%]). We hypothesise that the seroprevalence ofToxocaraspp. differs between forest and grassland rodents because of the higher contamination of grasslands by domestic dogs and wild canids. Our results underline the need for wide biomonitoring of both types of ecosystems to assess the role of rodents as indicators of environmental contamination with zoonotic pathogens.
Improved mineralization of dental enamel by electrokinetic delivery of F− and Ca2+ ions
Authors: Tay NamBeng , Gan HiongYap , de Sousa Frederico Barbosa , Shen Lu , Nóbrega Diego Figueiredo , Peng Chenhui , Kilpatrick-Liverman LaTonya , Wang Wei , Lavender Stacey , Pilch Shira , Han Jongyoon 
Published: January 2023

AbstractThis in vitro study evaluated the effects of the infiltration of F- and Ca2+ ions into human enamel by electrokinetic flow (EKF) on the enamel microhardness and F- content. Sound human enamel ground sections of unerupted third molars were infiltrated with de-ionized water by EKF and with F- ion by EKF respectively. All samples were submitted to two successive transverse acid-etch biopsies (etching times of 30 s and 20 min) to quantify F- ion infiltrated deep into enamel. Remarkably, sound enamel showed a large increase in microhardness (MH) after infiltration of NaF (p < 0.00001) and CaCl2 (p = 0.013) by EKF. Additionally, NaF-EKF increased the remineralization in the lesion body of artificial enamel caries lesions compared to controls (p < 0.01). With the enamel biopsy technique, at both etching times, more F- ions were found in the EKF-treated group than the control group (p << 0.05), and more fluoride was extracted from deeper biopsies in the NaF-EKF group. In conclusion, our results show that EKF treatment is superior in transporting Ca2+ and F− ions into sound enamel when compared to molecular diffusion, enhancing both the mineralization of sound enamel and the remineralization of artificial enamel caries.
A risk stratification and prognostic prediction model for lung adenocarcinoma based on aging-related lncRNA
Authors: Chen HuiWei , Peng Lihua , Zhou Dujuan , Tan NianXi , Qu GenYi 
Published: January 2023

AbstractTo create a risk model of aging-related long non-coding RNAs (arlncRNAs) and determine whether they might be useful as markers for risk stratification, prognosis prediction, and targeted therapy guidance for patients with lung adenocarcinoma (LUAD). Data on aging genes and lncRNAs from LUAD patients were obtained from Human Aging Genomic Resources 3 and The Cancer Genome Atlas, and differential co-expression analysis of established differentially expressed arlncRNAs (DEarlncRNAs) was performed. They were then paired with a matrix of 0 or 1 by cyclic single pairing. The risk coefficient for each sample of LUAD individuals was obtained, and a risk model was constructed by performing univariate regression, least absolute shrinkage and selection operator regression analysis, and univariate and multivariate Cox regression analysis. Areas under the curve were calculated for the 1-, 3-, and 5-year receiver operating characteristic curves to determine Akaike information criterion-based cutoffs to identify high- and low-risk groups. The survival rate, correlation of clinical characteristics, malignant-infiltrating immune-cell expression, ICI-related gene expression, and chemotherapeutic drug sensitivity were contrasted with the high- and low-risk groups. We found that 99 DEarlncRNAs were upregulated and 12 were downregulated. Twenty pairs of DEarlncRNA pairs were used to create a prognostic model. The 1-, 3-, and 5-year survival curve areas of LUAD individuals were 0.805, 0.793, and 0.855, respectively. The cutoff value to classify patients into two groups was 0.992. The mortality rate was higher in the high-risk group. We affirmed that the LUAD outcome-related independent predictor was the risk score (p < 0.001). Validation of tumor-infiltrating immune cells and ICI-related gene expression differed substantially between the groups. The high-risk group was highly sensitive to docetaxel, erlotinib, gefitinib, and paclitaxel. Risk models constructed from arlncRNAs can be used for risk stratification in patients with LUAD and serve as prognostic markers to identify patients who might benefit from targeted and chemotherapeutic agents.
Microcantilever-based current balance for precise measurement of the photon force
Authors: Pruchnik Bartosz , Orłowska Karolina , Świadkowski Bartosz , Gacka Ewelina , Sierakowski Andrzej , Janus Paweł , Gotszalk Teodor 
Published: January 2023

AbstractWe present a method for the quantitative determination of the photon force (PF)—the force generated by the radiation pressure of photons reflected from the surface. We propose an experimental setup integrating innovative microelectromechanical system (MEMS) optimized for the detection of photon force (pfMEMS). An active microcantilever was used as the force detector, while the measurement was conducted in a closed-loop setup with electromagnetic force compensation. In opposition to our previous works, this measurement method provides quantitative not qualitative assessment of PF interaction. Final current-balance setup is suitable for light sources from tens of microwatts to few watts. In our article, we present the results of the performed experiments, in which we measured the PF interactions in the range up to 67.5 pN with resolution of 30 fN in the static measurement.
Influence of the use of remineralizing agents on the tensile bond strength of orthodontic brackets
Authors: Domantaitė Milda , Trakinienė Giedrė 
Published: January 2023

AbstractThis study aimed to evaluate the influence of the use of remineralizing agents on the tensile bond strength. The study sample consisted of 80 recently extracted molars, which were randomly divided into four experimental groups (n = 20): groups FG1 and FG30, in which fluoride varnish was used, and groups RG1 and RG30, in which Recaldent tooth mousse was used. The mesiobuccal surfaces served as experimental, and distobuccal as control (n = 80). Brackets were bonded to both surfaces and were submitted to a tension test at different time intervals (T1 and T30). Tensile bond strength (TBS) and the amount of adhesive remnant (ARI) were assessed. A statistically significantly lower mean of TBS compared to the control group was found only in the FG1 group (p < 0.001), and no significant difference was found between the other groups. The FG1 group showed significantly higher ARI scores (p < 0.001) compared to the control group. No significant difference was found between the other groups. In conclusion, bonding brackets one day after applying fluoride varnish significantly reduced the TBS, but after 30 days it was set back to an optimal value. The use of Recaldent before orthodontic treatment had no adverse effect.
An optimal load indirect matching method without parameter identification and system efficiency optimization
Authors: Qiu Xueying , Sun Pan , Rong Enguo , Qiao Kangheng , Sun Jun , Wu Xusheng 
Published: January 2023

AbstractIn some wireless charging applications where the coil spacing varies in real time, such as UAV, electric boat and tram, etc., the traditional direct impedance matching method is difficult to identify the mutual inductance timely and accurately, thus affecting the efficiency optimization effect of the system. In this paper, an indirect impedance matching method without parameter identification is proposed, this method is based on the characteristic that the optimal voltage gain of the resonator is only related to its inherent parameters, and impedance matching can be achieved by controlling the voltage gain in real time. To further improve the efficiency of the system, a single-sided detuning design method is used to achieve soft switching of the inverter. Based on the optimal voltage gain expression derived by using both the indirect impedance matching method and the single-sided detuning design method, a compound control strategy for a series-series-compensated topology with dual-side power control is proposed to improve efficiency and stabilize the output voltage. A hardware prototype is built and a peak DC-to-DC efficiency with the optimal output resistanceRLat about 28.9 Ω is 91.58%. When the output resistanceRLis 100 Ω, the efficiency improved by 7% after using the proposed strategy.
Quantitative magnetic resonance imaging assessment of muscle composition in myotonic dystrophy mice
Authors: Bargiela Ariadna , Ten-Esteve Amadeo , Martí-Bonmatí Luis , Sevilla Teresa , Perez Alonso Manuel , Artero Ruben 
Published: January 2023

AbstractMyotonic dystrophy type 1 (DM1) is a severe autosomal dominant neuromuscular disease in which the musculoskeletal system contributes substantially to overall mortality and morbidity. DM1 stems from a noncoding CTG trinucleotide repeat expansion in the DMPK gene. The human skeletal actin long repeat (HSALR) mouse model reproduces several aspects of the disease, but the muscle-wasting phenotype of this model has never been characterized in vivo. Herein, we used quantitative MRI to measure the fat and muscle volumes in the leg compartment (LC) of mice. These acquired data were processed to extract relevant parameters such as fat fraction and fat infiltration (fat LC/LC) in HSALR and control (FBV) muscles. These results showed increased fat volume (fat LC) and fat infiltration within the muscle tissue of the leg compartment (muscle LC), in agreement with necropsies, in which fatty clumps were observed, and consistent with previous findings in DM1 patients. Model mice did not reproduce the characteristic impaired fat fraction, widespread fat replacement through the muscles, or reduced muscle volume reported in patients. Taken together, the observed abnormal replacement of skeletal muscle by fat in the HSALR mice indicates that these mice partially reproduced the muscle phenotype observed in humans.
Coronavirus covid-19 detection by means of explainable deep learning
Authors: Mercaldo Francesco , Belfiore Maria Paola , Reginelli Alfonso , Brunese Luca , Santone Antonella 
Published: January 2023

AbstractThe coronavirus is caused by the infection of the SARS-CoV-2 virus: it represents a complex and new condition, considering that until the end of December 2019 this virus was totally unknown to the international scientific community. The clinical management of patients with the coronavirus disease has undergone an evolution over the months, thanks to the increasing knowledge of the virus, symptoms and efficacy of the various therapies. Currently, however, there is no specific therapy forSARS-CoV-2 virus, know also as Coronavirus disease 19,and treatment is based on the symptoms of the patient taking into account the overall clinical picture. Furthermore, the test to identify whether a patient is affected by the virus is generally performed on sputum and the result is generally available within a few hours or days. Researches previously found that the biomedical imaging analysis is able to show signs of pneumonia. For this reason in this paper, with the aim of providing a fully automatic and faster diagnosis, we design and implement a method adopting deep learning for the novel coronavirus disease detection, starting from computed tomography medical images. The proposed approach is aimed to detect whether a computed tomography medical images is related to an healthy patient, to a patient with a pulmonary disease or to a patient affected with Coronavirus disease 19. In case the patient is marked by the proposed method as affected by the Coronavirus disease 19, the areas symptomatic of the Coronavirus disease 19 infection are automatically highlighted in the computed tomography medical images. We perform an experimental analysis to empirically demonstrate the effectiveness of the proposed approach, by considering medical images belonging from different institutions, with an average time for Coronavirus disease 19 detection of approximately 8.9 s and an accuracy equal to 0.95.