bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the System of Mandatory Requirements to Business under the Digital Transformation of Economy
Authors: Minich S. A. 
Published: August 2023

Objective: to elaborate scientifically substantiated proposals for improving the system of mandatory requirements in the sphere of business and other economic activity under formation of digital economy, taking into account the foreign experience of eliminating barriers for business and the available practice of legislation optimization in this sphere.Methods: the research methodological basis consists of traditional general and specific methods of scientific cognition: dialectical, formal-logical, historical-comparative, systematic, terminological, general logic methods (analysis, synthesis, generalization, induction, deduction, etc.), as well as special methods: historical-legal, formal-legal, and method of comparative jurisprudence.Results: the author investigated and systematized theoretical approaches and experience of improving the system of mandatory requirements in foreign countries and the Russian Federation; the possibilities of introducing the most successful innovative legal instruments and practices to improve the regulation of economic relations were considered. The role of a retrospective assessment of the regulatory impact of existing regulatory legal acts containing mandatory requirements in addressing issues of reducing burdensome rules and ensuring legal stability in the context of digital transformation of the economy was determined. The international experience of implementing the regulatory guillotine mechanism was considered; its essence, purpose, tasks, basic principles, and algorithm of operation were revealed. The issues of establishing and evaluating the application of the requirements for business contained in regulatory legal acts were analyzed.Scientific novelty: the author’s comprehensive analysis of existing scientific developments on improving the system of mandatory requirements for business; systematization of scientific and theoretical approaches to the selection of innovative legal instruments to eliminate excessive legal regulation of economic relations; generalization of successful foreign practices in the implementation of “regulatory guillotine” measures.Practical significance: recommendations were developed for effective reduction of burdensome requirements that negatively affect the development of business in the context of digital transformation of the economy. Conditions were determined for the implementation of a full-fledged regulatory impact assessment procedure and the successful implementation of regulatory reforms. The results of the study can be used in standard-setting activities and in the educational process when elaborating educational programs in Economics and Law.
Direct Laser Photocoagulation of the Retinal Pigment Epithelium: A Novel Method to Seal Retinal Breaks during Pars Plana Vitrectomy for Retinal Detachment
Authors: Du Shu , Yang Xun , Zha Youyou , Chen Xing , Zhang Jing , Kuhn Ferenc 
Published: August 2023

Abstract
Aims: To examine the clinical effectiveness of employing direct retinal pigment epithelium (RPE) laser photocoagulation to create chorioretinal adhesion around the retinal breaks.
Methods: Twenty eyes of 20 patients were included in the study; all eyes had rhegmatogenous or combined rhegmatogenous-tractional retinal detachment. Direct RPE laser photocoagulation during vitrectomy, using power of 100-150 mw for of 120-200 ms duration, was performed in the area where the edges of each retinal break would settle following retinal reattachment. The thickness of the neuroretina over the treated area was compared to that measured after traditional transretinal laser photocoagulation.
Results: The mean follow-up time was 24 (11-46) months. Postoperatively, an ophthalmoscopically visible pigmentary reaction developed over the treated area, except for a single eye where the retinal break was located in an area of myelinated nerve fibres. There were no serious complications, and the retinas in all 20 eyes remained reattached. The mean best-corrected visual acuity (BCVA) at the final follow-up was significantly higher than that before surgery (p=0.001). The thickness of the neuroretina at 1 month after surgery greatly differed between areas of direct versus transretinal laser photocoagulation: 217 μm in the former and 104 μm in the latter group.
Conclusions: The efficacy of direct RPE photocoagulation in retinal break sealing equals the effect of traditional transretinal photocoagulation, but without risking damaging the neurosensory retina, and the laser application is not hindered by retinal opacities.
Stability Classification of Stock Market Using Temporal Rule-Based Classification
Authors: Fattah Polla , Aickelin Uwe , Wagner Christian , Rashid Tarik A. , Jafar  , A. Bryar 
Published: August 2023

Abstract
Economists have sought to predict stock market prices for decades with varying degrees of success. This study classifies stocks according to their stability in two consequent financial quarters (depending on whether the majority of stocks remain in the same stability group, which can indicate forecastability). However, classifying temporal information like stock market data using available methods produces complicated rules that cannot be easily interpreted by human experts. To reduce this complication a new approach of rule-based temporal classification is used. The method combines human-provided rules with machine optimisation to produce classes that can be easily interpreted by experts, enabling them to comprehend the complicated temporal dimension of the data. Rules provided by human experts might be via generalization of the temporal data using statistical functions like standard deviation and averages. Initially, each rule will have a range of possible values that can be reduced to a single one. For this study, we classify the stability of stock market data of the S&P 500 for two constitutive financial quarters to test if stocks have the same stability or not. The results show that the classes for stock markets are different beyond random chance, which might be an indication of the viability of forecasting stock markets depending on their old trends.
Path Planning of Mobile Robots under Uncertain Navigation Environments using FCM clustering ANFIS
Authors: MOHANTY PRASES KUMAR 
Published: August 2023

Abstract

In this paper an improved Multiple Adaptive Neuro-Fuzzy Inference System (MANFIS) to solve the wheeled mobile robots path planning in unstructured environments is proposed. The Fuzzy C-Means (FCM) clustering method is used in ANFIS to decrease the input data size, which leads to predict the efficiency of the proposed robot path planning model. The FCM clustering method allow classifying the robot sensors extracted input data into clusters; each cluster has similar properties that assists to develop the correlation between data and as a result simplify the proposed model. The design MANFIS architecture takes both the advantages of artificial neural network which has self-learning ability and fuzzy system to describe the uncertain phenomena of the data. Finally, by combining cluster data and MANFIS an optimum velocity for left and right wheel of the robot is determined, which safely navigate the robot in an optimized route. The simulation and experimental results show that the proposed path planning method is effective and can be implemented for any complex environments. This paper identifies and describes a new development on path planning technique that will help the robots to navigate in any kind of uncertain navigation environments.
Density kernel depth for outlier detection in functional data
Authors: Hernández Nicolás , Muñoz Alberto , Martos Gabriel 
Published: August 2023

Abstract
In this paper, we propose a novel approach to address the problem of functional outlier detection. Our method leverages a low-dimensional and stable representation of functions using Reproducing Kernel Hilbert Spaces (RKHS). We define a depth measure based on density kernels that satisfy desirable properties. We also address the challenges associated with estimating the density kernel depth. Throughout a Monte Carlo simulation we assess the performance of our functional depth measure in the outlier detection task under different scenarios. To illustrate the effectiveness of our method, we showcase the proposed method in action studying outliers in mortality rate curves.
Secure Sharing of Medical Images using Watermarking Technique
Authors: Priyadarshini Priyanka , Naik Kshiramani 
Published: August 2023

Abstract
The advanced healthcare system needs to share electronic patient record (EPR) among different hospitals and specialists for better and easy treatment of patient. However, the protection of the EPR from unauthorized access and malicious attacks is primary concern to preserve the privacy and proper diagnosis. Medical image watermarking in E-health care system is a suitable technique for safety and confidentiality of EPR. In this paper the medical image is separated into region of interest (ROI) and region of non interest (RONI) part, subsequently additive encryption technique is applied to embed patient record into ROI part of cover media. Backup of original information is embedded into RONI part for tamper detection. Thereafter visible hospital logo is embedded into watermarked medical image for identification purpose. Result of this algorithm tested over few medical images and that produces effectiveness of data payload and integrity.
A two-stage approach to the multiple-agent orienteering problem with stochastic weight and capacity constraints
Authors: Liu Xinrui , Luo XingGnag , Zhang Zhongliang , Hu Yuning , Hang Hang 
Published: August 2023

Abstract
The Multiple-Agent Orienteering Problem with Capacity Constraints (MAOPCC) is one kind of routing problem that finds applications in both tourism and transportation industries. The MAOPCC aims to find feasible routeS with maximum profit considering time constraints. In this paper, we extend the MAOPCC to the Multiple-Agent Orienteering Problem with Stochastic Weight and Capacity Constraints (MAOPCCSW) to address the uncertainty in practical situations. The problem is solved using a two-stage stochastic model with recourse and hard time constraints. The model considers the effect of stochastic weights on the expected total profit value during the modeling stage. The two-stage model is solved with Sample Average Approximation (SAA), which converges to the optimal solution with a high computational cost. Therefore, for solving large instances, a heuristic method is developed, which utilizes the problem structure of the MAOPCCSW and explicitly considers relevant uncertainties. In our experimental analysis, we demonstrate the effectiveness of the MAOPCCSW method, which outperforms both the standard deterministic method and the deterministic method amended with real-time information.
Audio-Biofeedback Versus the Scale Method for Improving Partial Weight-Bearing Adherence in Healthy Older Adults: a Randomised Trial
Authors: von Aesch Arlene Vivienne , Häckel Sonja , Kämpf Tobias , Baur Heiner , Bastian Johannes Dominik 
Published: August 2023

Abstract
Background
Adherence to partial weight-bearing prescription is poor, especially amongst older adults taught with traditional methods. Reasons for this remain unclear and improvements to the instruction of partial weight-bearing are necessary. This randomised controlled trial aimed to investigate how the use of audio-biofeedback during the instruction of partial weight-bearing affected adherence to a weight-bearing limit of 20 kg, compared to the scale method, in older adults.
Methods
The primary outcome measure was the amount of loading of the partial weight-bearing leg during functional mobility activities, measured as the ground reaction force in Newtons and converted to kilograms. Included were healthy volunteers 60 years of age or older without gait impairment. Participants were randomised into two groups. Blinding was not possible. Partial weight-bearing of 20 kg using crutches was trained with audio-biofeedback (intervention group) or a bathroom scale (control group). The degree of weight-bearing was measured during functional mobility activities (standing, sit-stand-sit, step-up/down and walking) with OpenGo sensor insoles (Moticon ReGo AG, Munich, Germany). A mean load between 15-25 kg was defined as adherent. Weight, height, cognitive function and grip strength were measured. Linear regression analyses were performed to identify factors influencing adherence.
Results
Thirty volunteers (16 females, 71±6 years, weight 74±17 kg; height 169±9 cm) participated in the trial, fifteen participants in each group. There were no drop-outs. There was no statistically significant difference in weight-bearing between both groups for the activities measured. For the sit-stand-sit activity, weight-bearing for the audio-biofeedback group (21.7±16.6 kg) and the control group (22.6±13 kg) were within the target range. For standing, loading was below the lower threshold (10±7 vs. 10±10 kg). Weight-bearing was above the upper threshold for both groups for: walking (26±11 vs. 34±16), step-up (29±18 vs. 34±20 kg) and step-down (28±15 vs. 35±19 kg). Lower cognitive function, older age, and higher body mass index were associated with poorer adherence to partial weight-bearing. There were no incidents or harms during the trial.
Conclusion
Audio-biofeedback delivered no statistically significant benefit over the scale method. Lower cognitive function, older age and higher BMI were associated with poorer adherence to partial weight-bearing instructions.
Trial registration
Not applicable due to the cross-sectional design (one measurement point, no intervention).
Perennial grassland systems possess more complex bacterial communities and inter-domain networks across three land-use types
Authors: Zhu Ruifen , Liu Chang , Xu Yuandong , Sun Wanbin , chen jishan 
Published: August 2023

Abstract
Aims Continuous cropping is a common cropping practice in northeast China. This practice can positively or negatively impact soil microbial community. However, the response of rhizosphere microbial community structures, specific microbial taxa, and co-occurrence patterns to different continuous cropping systems are rarely tested.Methods In this study, soil samples were collected from the rhizosphere of three different continuous cropping systems (Corn, Alfalfa and Sheepgrass) were analyzed for microbial community (bacterial and fungal) composition and structural responses using an Illumina HiSeq high-throughput sequencing technique.Results Our results revealed that the α- and β-diversity indices of the fungal communities were significantly different across the three continuous cropping systems. The analysis of the molecular ecological network revealed that Alfalfa communities had the highest number of nodes and edges in the bacterial network while Sheepgrass had the highest number of nodes and edges in the fungal network. To distinguish differences between the co-occurring taxa among the three cropping systems, we compared the number of positive and negative links within and between microbial groups. This highlights that perennial grassland systems had more complex bacterial and inter-domain networks. Our inter-domain networks also revealed the predominant role of fungi as a key taxon in soil microbiome networks across the three land-use types.Conclusions Our results demonstrated that continuous cropping of perennial forage crops enhanced soil microbial diversity, network complexity and multifunctionality. Moreover, changes in microbiota characteristics are positively dependent on forage-induced changes in soil multifunctionality.
Associations of Self-Reported Sun Exposure and 25- Hydroxyvitamin D with Blood Pressure: Cross-Sectional Analysis from a Multi-Ethnic Community Sample
Authors: Rahman Juma , Sluyter John , Scragg Robert 
Published: August 2023

Abstract
Background: Physiological and epidemiological studies indicate that vitamin D may have several antihypertensive actions, and sun exposure is the primary source of vitamin D in humans. However, the results of recent trials are inconsistent. We carried out a cross-sectional analysis to evaluate the relationships between serum 25-hydroxyvitamin D [25(OH)D], sun exposure, and blood pressure (BP).
Methods: We performed univariate and multivariable regression analyses. Sun exposure was assessed using a questionnaire to investigate the frequency of this activity in the past three months. Serum 25(OH)D was measured by liquid chromatography-tandem mass spectrometry from blood samples collected during baseline assessment. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured by an Omron T9P oscillometric device.
Results: A total of 5,108 study participants aged 50–84 years were recruited from family practices in New Zealand. Age, ethnicity, BMI, and history of high BP were significantly associated with all BP indices. Serum 25(OH)D was not associated with systolic blood pressure (SBP) [25(OH)D <25 nmol/L mean diff -0.7 mmHg (1.5) compared to ≥75 nmol/L; P = 0.62] or diastolic blood pressure (DBP) [25(OH)D <25 nmol/L mean diff 0.7 (0.8) compared to ≥75 nmol/L; P = 0.79]. Sun exposure was positively associated (P<0.0001) with serum 25(OHD) level. When all key variables were adjusted for, sun exposure was positively associated (P < 0.05) with SBP [3.1 mmHg (1.0) compared to lowest; P = 0.01] and DBP [1.7 mmHg (0.5) compared to lowest; P = 0.01], but 25(OH)D was unrelated to these. Independently of sun exposure and 25(OH)D, BP varied with season, being lowest in summer (by up to 3 mmHg).
Conclusion:
These results indicate that sun exposure and winter season are associated with higher BP, independently of one another and of 25(OH)D, while the latter was unrelated to BP. The winter increase in BP is likely due to other factors than low vitamin D levels at that time of year (Figure 1).
Preoperative sequential short-course radiation therapy and FOLFOX chemotherapy versus long-course chemoradiotherapy for locally advanced rectal cancer: A multicenter, randomized controlled trial (SOLAR trial)
Authors: Kang Min Kyu , Yeun Park Soo , Park Jun Seok , Kim Hye Jin , Kim Jong Gwang , Kang Byung Woog , Baek Jin Ho , Cho Seung Hyun , Seo An Na , Kim Duck-Woo , Kim Jin , Baek Se Jin , Kim Ji Hoon , Ha Gi Won , Park Eun Jung , Park In Ja , Kim Chang Hyun , Kang Hyun , Choi Gyu-Seog , Kim Ji Yeon 
Published: August 2023

Abstract
Background Preoperative (chemo)radiotherapy has been widely used as an effective treatment for locally advanced rectal cancer (LARC), leading to a significant reduction in pelvic recurrence rates. Because early administration of intensive chemotherapy for LARC has more advantages than adjuvant chemotherapy, total neoadjuvant therapy (TNT) has been introduced and evaluated to determine whether it can improve tumor response or treatment outcomes. This study aims to investigate whether short-course radiotherapy (SCRT) followed by intensive chemotherapy improves oncologic outcomes compared with traditional preoperative long-course chemoradiotherapy (CRT).Methods A multicenter randomized phase II trial involving 364 patients with LARC (cT3–4, cN+, or presence of extramural vascular invasion) will be conducted. Patients will be randomly assigned to the experimental or control arm at a ratio of 1:1. Participants in the experimental arm will receive SCRT (25 Gy in 5 fractions, daily) followed by four cycles of FOLFOX (oxaliplatin, 5-fluorouracil, and folinic acid) as a neoadjuvant treatment, and those in the control arm will receive conventional radiotherapy (45−50.4 Gy in 25−28 fractions, 5 times a week) concurrently with capecitabine or 5-fluorouracil. As a mandatory surgical procedure, total mesorectal excision will be performed 2–5 weeks from the last cycle of chemotherapy in the experimental arm and 6–8 weeks after the last day of radiotherapy in the control arm. The primary endpoint is 3-year disease-free survival, and the secondary endpoints are tumor response, overall survival, toxicities, quality of life, and cost-effectiveness.Discussion This is the first Korean randomized controlled study comparing TNT with traditional preoperative LC-CRT for LARC. The involvement of experienced colorectal surgeons ensures high-quality surgical resection. SCRT followed by FOLFOX chemotherapy is expected to improve disease-free survival compared with CRT, with potential advantages in tumor response, quality of life, and cost-effectiveness.Trial registration This trial is registered at Clinical Research Information under the identifier Service KCT0004874 on April 02, 2020, and at Clinicaltrial.gov under the identifier NCT05673772 on January 06, 2023.
ADHD Prescription Patterns and Medication Adherence during the COVID-19 pandemic
Authors: Cunniff Peter , Ahsan Amil , McCrary Catherine , Dien Tracy , Kuhn Tristan , Vazifedan Turaj , Harrington John 
Published: August 2023

Abstract
Background
COVID-19 put students with attention deficit hyperactivity disorder (ADHD) at risk of disruptions to their medication regimen and school performance, and telehealth appointments became more common during the pandemic. Our study aimed to identify if ADHD medication regimens were disrupted through analyzing prescription refill schedules and if telehealth management demonstrated a higher rate of adherence.
Methods
Patients between the ages of 8–18 with a history of ADHD for three or more years medically managed with four or more prescription refills between January 2019 and May 2022 were reviewed. A retrospective chart review collected age, sex, race, refill schedule, and appointment schedule.
Results
The total percentage of patients who had their ADHD medications refilled between January 2019 and March 2020 ranged from 40–66% versus 31–44% between April 2020 and May 2022. Additionally, the total percentage of patients who had quarterly ADHD management appointments between January 2019 and March 2020 ranged between 59–70% versus 33–50% between April 2020 and June 2022. The number of months with ADHD prescription refills over the last three years was significantly higher among those who had both virtual and in-person visits than those who had just in-person visits, p < 0.001.
Conclusions
Since the start of the pandemic, ADHD patients have both refilled their prescriptions and returned to clinic less frequently. This data suggests a need to re-evaluate the ADHD symptoms of GAP patients periodically and return them to a more consistent medication regimen. Telehealth appointments are a potential solution to increase adherence.