bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective comparison of monochorionic diamniotic twin pregnancies stratified by spontaneous or artificial conception
Authors: Roero Sofia , Arduino Silvana , Arese Arianna , Fea Teresa , Ferrando Isabella , Scaltrito Gabriella , Casula Viola , Ronco Alice , Bossotti Carlotta , Zizzo Roberto , Scali Roberto , Revelli Alberto 
Published: July 2023

Abstract

Objectives
To compare outcomes of monochorionic diamniotic (MCDA) twin pregnancies by in vitro fertilization (IVF) vs. spontaneously conceived counterparts.

Methods
Retrospective comparison. Data about MCDA twin pregnancies, conceived spontaneously or by IVF, attending the Twin Pregnancy Care Unit of Sant’Anna Hospital in Turin (Italy) between January 1st 2010 and March 31st 2022, were collected retrospectively. Obstetric, fetal, and neonatal outcomes of MCDA twin pregnancies by IVF were compared to those of spontaneously conceived counterparts. Data were described by univariate and multivariate analysis.

Results
541 MCDA twin pregnancies were included in the study, among which 45 conceived by IVF and 496 spontaneously conceived. Women with IVF twins were older than those who conceived spontaneously (36.7 ± 5.7 vs. 32.1 ± 5.2 years; p<0.001). No significant difference in the prevalence of pregnancy complications between the two groups was found, except for an increased incidence of hypertensive disorders among IVF pregnancies (17.8 vs. 8.5 %; p=0.039), which resulted nonsignificant after adjusting for maternal age and parity (aOR 1.9, 95 % CI 0.8–4.6). Data about 1,046 live born babies (90 conceived by IVF and 956 spontaneously) were also collected: perinatal outcomes did not differ between the two groups.

Conclusions
Our results suggest that MCDA twin pregnancies following IVF are not at increased risk of adverse outcomes compared to spontaneous MCDA twin pregnancies.
Bayesian analysis of Formula One race results: disentangling driver skill and constructor advantage
Authors: van Kesteren Erik-Jan , Bergkamp Tom 
Published: July 2023

Abstract
Successful performance in Formula One is determined by combination of both the driver’s skill and race-car constructor advantage. This makes key performance questions in the sport difficult to answer. For example, who is the best Formula One driver, which is the best constructor, and what is their relative contribution to success? In this paper, we answer these questions based on data from the hybrid era in Formula One (2014–2021 seasons). We present a novel Bayesian multilevel rank-ordered logit regression method to model individual race finishing positions. We show that our modelling approach describes our data well, which allows for precise inferences about driver skill and constructor advantage. We conclude that Hamilton and Verstappen are the best drivers in the hybrid era, the top-three teams (Mercedes, Ferrari, and Red Bull) clearly outperform other constructors, and approximately 88 % of the variance in race results is explained by the constructor. We argue that this modelling approach may prove useful for sports beyond Formula One, as it creates performance ratings for independent components contributing to success.
Overexpression of TRIM28 predicts an unfavorable prognosis and promotes the proliferation and migration of hepatocellular carcinoma
Authors: Chen Yuji , Pang Jinshu , Liao Wei , Wan Weijun , Kang Tong , Gan Xiangyu , Lin Peng , Wen Dongyue , He Yun , Yang Hong 
Published: July 2023

Abstract

Objectives
Previous studies have shown that tripartite motif-containing 28 (TRIM28) might be a latent target for cancer therapy. However, the detailed roles and mechanisms of TRIM28 in hepatocellular carcinoma (HCC) remain ambiguous.

Methods
We systematically analyzed TRIM28 mRNA expression and protein levels in HCC tissues based on large-scale data and publicly available immunohistochemistry images. We estimated the prognostic capacity of TRIM28 in HCC. Additionally, we performed gene enrichment, immune infiltration, and drug sensitivity analyses to further explore the roles of TRIM28 in HCC. To determine the effect of TRIM28 expression on HCC cell proliferation and migration, successful transfection of siRNAs was conducted in MHCC97-L and Huh7 cells, followed by cell functional assays.

Results
We verified the overexpression of TRIM28 in HCC at the mRNA and protein levels. The summary receiver operating characteristics curve with the area under curve of 0.84 (95 % CI: 0.81–0.87) indicated the high accuracy of increasing TRIM28 expression for discriminating HCC from non-HCC tissues. According to The Cancer Genome Atlas datasets, TRIM28 mRNA expression was significantly related to age, grade, stage, and pathologic T (p<0.05). Increased TRIM28 expression levels were significant correlated to poor survival in HCC patients. An enrichment analysis suggested that TRIM28-reated genes primarily participated in the spliceosome signaling pathway, with hub genes including SNRPA1, SNRPF, SNRPD1, SF3B2, SNRPB, SNRPE, and EFTUD2. TRIM28 expression was correlated with the infiltration of five immune cells. Higher TRIM28 expression was linked to better sensitivity of tumor cells to pluripotin. Molecular docking showed that pluripotin could bind to TRIM28. Further, knockdown of TRIM28 inhibited the proliferation and migration of HCC cells.

Conclusions
TRIM28 is highly expressed in HCC and contribute to the proliferation and migration of HCC cells, leading to unfavorable outcomes. These findings indicate TRIM28 promise as a novel prognostic indicator.
Iconographic Trends in Roman Imperial Coinage in the Context of Societal Changes in the Second and Third Centuries CE: A Small-Scale Test of the Affluence Hypothesis
Authors: Glomb Tomáš , Kaše Vojtěch , Zavřel Viktor 
Published: July 2023

Abstract
This article presents a quantitative analysis of iconographic trends in the depiction of deities in the coinage of the Roman Empire throughout the second and third centuries CE to explore temporal shifts in Roman imperial propaganda in the context of developments and pressures in affluence, prosperity, and political stability. Next to providing deeper insight into the topic of Roman imperial ideology, the article’s main objective is to test the validity of the so-called affluence hypothesis from the debate on cultural evolution. The hypothesis predicts that an increase in affluence and prosperity leads to the emergence of moralizing themes in religion. Based on the comparison of the iconographic trends in Roman coinage, as represented by the Online Coins of the Roman Empire project portal of coin types, with changes in affluence and prosperity indicators for the period of the second and third centuries CE, the results suggest that in times of political stability and prosperity, Roman Empire emphasized moralizing deities on coins more often than in times of crisis. In contrast, martial deities and those oriented on dominating power were promoted on coins more frequently in turbulent times. In this small-scale case study, the results support the arguments of the affluence hypothesis.
TARPγ2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina
Authors: Stincic Todd , Gayet-Primo Jacqueline , Taylor W. Rowland , Puthussery Teresa 
Published: July 2023

AbstractAMPA receptors (AMPARs) are the major mediators of fast excitatory neurotransmission in the retina as in other parts of the brain. In most neurons, the synaptic targeting, pharmacology, and function of AMPARs are influenced by auxiliary subunits including the transmembrane AMPA receptor regulatory proteins (TARPs). However, it is unclear which TARP subunits are present at retinal synapses and how they influence receptor localization and function. Here, we show that TARPɣ2 (stargazin) is associated with AMPARs in the synaptic layers of the mouse, rabbit, macaque, and human retina. In most species, TARPɣ2 expression was high where starburst amacrine cells (SACs) ramify and transcriptomic analyses suggest correspondingly high gene expression in mouse and human SACs. Synaptic expression of GluA2, GluA3, and GluA4 was significantly reduced in a mouse mutant lacking TARPɣ2 expression (stargazer mouse;stg), whereas GluA1 levels were unaffected. AMPAR-mediated light-evoked EPSCs in ON-SACs fromstgmice were ∼30% smaller compared with heterozygous littermates. There was also loss of a transient ON pathway-driven GABAergic input to ON-SACs instgmutants. Direction-selective ganglion cells in thestgmouse showed normal directional tuning, but their surround inhibition and thus spatial tuning was reduced. Our results indicate that TARPɣ2 is required for normal synaptic expression of GluA2, GluA3, and GluA4 in the inner retina. The presence of residual AMPAR expression in the stargazer mutant suggests that other TARP subunits may compensate in the absence of TARPɣ2.
Porcine-specific expression of the three functional CYP19 paralogs in early conceptus, placenta, and gonads
Authors: Gomes Lucas Caroline , Sullivan Riley M , Pfeiffer Caroline A , Chen Paula R , Kim JaeWoo , Sponchiado Mariana , Conley Alan J , Prather Randall S , Wells Kevin D , Geisert Rodney D 
Published: July 2023

In brief
Aromatase catalyzes the synthesis of estrogens and has been shown to have an important role during the establishment of pregnancy in the pig. This study confirmed the differential expression of the three aromatase isoforms.

Abstract
Although three porcine aromatase isoforms have been identified, their gene expression profiles in reproduction are still poorly understood. Here, we identified by Sanger sequencing unique nucleotide signatures for the three paralogous copies of Cyp19 and analyzed by RT-PCR the occurrence of the Cyp19 and Cyp17a1 transcripts at different tissues and stages of conceptus and fetal–placental development. Cyp19a1 and Cyp19a3 expressions were detected in conceptuses and gonads, respectively. Cyp19a2 transcripts were identified on both the conceptuses and the placenta samples. Transcripts for Cyp17a1 were detected predominantly in conceptus and gonads. In the endometrium of day 21 pregnant females, as well as days 12 and 17 pseudopregnant females, we did not detect the expression of Cyp19a1, Cyp19a2, or Cyp19a3. In our study, we have demonstrated distinct transcriptional regulation for the three functional Cyp19 paralogs and a potential role for Cyp17a1 in controlling the secretion of estrogen from the conceptus and the placenta.
Pemidanaan Terhadap Pelaku Pengulangan Tindak Pidana Kekerasan Dalam Rumah Tangga
Authors: Priyadi Riza , Fitriasih Surastini 
Published: July 2023

Domestic violence often occurs repeatedly, as a result, the victim experiences violence again. Several studies state that cases of domestic violence can be resolved through restorative justice outside the court, with the aim of maintaining the integrity of the household. However, in several cases it was found that the perpetrators violated peace agreements and returned to violence. This article will discuss the repetition of domestic violence crimes. This study uses a normative juridical method by examining research materials from law no. 23 of 2004, the Criminal Code, theory of criminal law, the concept of restorative justice and recidive theory. From the results of this study it was concluded that agreements to resolve cases of domestic violence through restorative justice were often violated by the perpetrators, so that the violence reoccurred. A peace agreement cannot be used as a basis for ballast in imposing criminal sanctions. Therefore, it is necessary to have provisions to regulate the implementation of restorative justice and provisions regarding the outcome of a peace agreement as a weighting basis if there is a repetition of the crime of domestic violence.Keywords: Domestic Violence, Restorative Justice, Repetition of Domestic Violence Crimes Abstrak: Kekerasan dalam rumah tangga kerap terjadi secara berulang, akibatnya korban kembali mengalami kekerasan. Beberapa penelian menyebutkan bahwa perkara kekerasan dalam rumah tangga dapat diselesaikan melalui restorative justice di luar pengadilan, dengan tujuan untuk mempertahankan keutuhan rumah tangga. Akan tetapi dalam beberapa kasus ditemukan bahwa pelaku melanggar kesepakatan perdamaian dan kembali melakukan kekerasan. Artikel ini akan membahas mengenai pengulangan tindak pidana kekerasan dalam rumah tangga. Penelitian ini menggunakan metode yuridis normatif dengan mengkaji bahan-bahan penelitian dari Undang-Undang No. 23 tahun 2004, Kitab Undang-Undang Hukum Pidana, teori hukum pidana, konsep restorative justice dan teori recidive. Dari hasil penelitian ini menghasilkan kesimpulan bahwa kesepakatan penyelesaian perkara kekerasan dalam rumah tangga melalui restorative justice seringkali dilanggar oleh pelaku, sehingga kekerasan terjadi kembali. Kesepakatan damai tidak dapat dijadikan dasar sebagai pemberat dalam penjatuhan sanksi pidana. Oleh karenanya perlu ada ketentuan untuk mengatur pelaksanaan restorative justice dan ketentuan mengenai hasil kesepakatan damai sebagai dasar pemberat apabila terjadi pengulangan tidak pidana kekerasan dalam rumah tangga.Kata Kunci: Kekerasan Dalam Rumah Tangga, Restorative Justice, Pengulangan Tindak Pidana Kekerasan Dalam Rumah Tangga
Tinjauan Yuridis Terhadap Pemutusan Hubungan Kerja Sepihak Di Masa Pandemi Covid-19 Berdasarkan Undang-Undang tentang Ketenagakerjaan
Authors: Anggraeni RR Dewi , Imanuddin Iman , Ahmad Pendi 
Published: July 2023

Employment challenges in emerging countries, especially Indonesia, are common. In Indonesia, the corporation unilaterally terminated employees. The global economy has increased COVID-19-related layoffs. Thus, unemployment rose in several nations. Article 1 point 2 of Law Number 13 of 2003 on Manpower defines labor as “everyone who is able to produce goods or services to meet his own needs and the needs of society.” In line with Law Number 13 of 2003 concerning Employment and Unemployment Barriers for Unilaterally Dismissed Workers, the problem is identified and solved by determining the company's unilateral termination of employment. This study method uses empirical law (statute approach) and a conceptual approach. The research found that Article 151 of the Law on Job Creation explains Termination of Employment (PHK). Article 153 of the Job Creation Law governs PHK termination. The PHK form lists several causes for termination. If not unilateral and harmful, termination of employment (PHK) is legal. The Job Creation Law prevents employers from unilaterally terminating employment (PHK). Law Number 2 of 2004 on Settlement of Industrial Relations Disputes forbids, save for specified conditions that force termination.Keywords: Juridical Review; Layoffs; COVID-19; Employment AbstrakTantangan ketenagakerjaan di negara-negara berkembang, khususnya Indonesia, merupakan hal yang biasa. Di Indonesia, korporasi memberhentikan karyawan secara sepihak. Ekonomi global telah meningkatkan PHK terkait COVID-19. Dengan demikian, pengangguran meningkat di beberapa negara. Pasal 1 angka 2 Undang-Undang Nomor 13 Tahun 2003 tentang Ketenagakerjaan mendefinisikan tenaga kerja sebagai “setiap orang yang mampu menghasilkan barang atau jasa untuk memenuhi kebutuhannya sendiri dan kebutuhan masyarakat”. Sejalan dengan Undang-Undang Nomor 13 Tahun 2003 tentang Hambatan Ketenagakerjaan dan Pengangguran Bagi Tenaga Kerja yang Diberhentikan Secara Sepihak, permasalahan tersebut diidentifikasi dan diselesaikan dengan penetapan pemutusan hubungan kerja sepihak oleh perusahaan. Metode penelitian ini menggunakan hukum empiris (statute approach) dan pendekatan konseptual. Hasil penelitian menemukan bahwa Pasal 151 UU Cipta Kerja menjelaskan Pemutusan Hubungan Kerja (PHK). Pasal 153 UU Cipta Kerja mengatur pemutusan PHK. Formulir PHK mencantumkan beberapa penyebab penghentian. Jika tidak sepihak dan merugikan, pemutusan hubungan kerja (PHK) adalah sah. UU Cipta Kerja mencegah pengusaha melakukan pemutusan hubungan kerja (PHK) secara sepihak. Undang-Undang Nomor 2 Tahun 2004 tentang Penyelesaian Perselisihan Hubungan Industrial melarang, kecuali syarat-syarat tertentu yang memaksa pemutusan hubungan kerja.Kata Kunci: Tinjauan Yuridis; PHK; Covid-19; Ketenagakerjaan
High-resolution record of Paleoclimate during the late Quarternary, recovered from Con Moong cave - North Vietnam
Authors: Luu Thi Phuong Lan , B. Ellwood Brooks , Nguyen Khac Su , Hsung Wang Wei- , Doan Dinh Lam , Nguyen Thanh Dung , Nguyen Thi Mai 
Published: July 2023

To clarify the paleoclimatic events in Northern Vietnam during the Late Quaternary, 132 Con Moong - Thanh Hoa cave sediment samples were collected to analyze magnetic susceptibility (χ), δ18O, and δ13C. Based on the tendency in the value of χ Con Moong's sediment, 14 climate zones that change continuously from warm to cold were identified. These climate zones also correspond to the changing trend of δ18O and δ13C. The period of 14 magnetic zones is referenced from the extrapolation of four 14C data. These alternating cold-warm χ sequences correspond to the Composite Reference Section (CRS) developed in Southern Europe from a χ zonation of multiple caves. The paleoclimate characteristics, including the Heinrich H2 and H1 climate events, the Bølling/Allerød, and Younger Dryas warm-cold events, were elucidated for Northern Viet Nam from ~28.000 to ~10.000 yr BP.
PARENTAL RIGHTS TO PARTICIPATE IN A CHILD’S PERSONALITY DEVELOPMENT AND ITS RELIGIOUS AND MORAL UPBRINGING AND THE CHILD’S RIGHT TO FREEDOM OF CHOICE: OBSERVATIONS ON THE FIELD OF TENSION CAUSED BY THE IRRATIONAL IN A HUMAN RIGHTS DISPENSATION
Authors: JMT Labuschagne  , JC Bekker  , GJ van Zyl  
Published: July 2023

One of the factors that must be taken into account in child custody cases is the religious upbringing of the child. If the parents agree, there is normally no issue. The courts will not interfere, unless the parents' religious practices are not in the child's best interests. Courts have consistently held that the parents' autonomy in this regard is a fundamental right.
In this article the authors argue that religious upbringing is implicit in parenthood. At an early age a child does not have a choice. It is indeed strange to suggest that young children have a choice, as if it is presented to them on a menu. Parents have a right and a duty to promote the development of their children's character, value system and spiritual and moral well-being.
Estilos de crianza parental y conductas agresivas en adolescentes de una institución educativa pública, Juliaca
Authors: Larico Viamonte Rocina , Quispe Lupaca Erika Victoria 
Published: July 2023

Objetivo: determinar la relación entre estilos de crianza y el nivel de conductas agresivas en adolescentes de una institución educativa pública, Juliaca, 2022. Metodología: de enfoque cualitativo de nivel correlacional, de diseño no experimental. Por otro lado, la población fue de 796 sujetos de ambos sexos de 14 a 17 años de edad que representan a un tipo de muestra no probabilístico por conveniencia. Los instrumentos utilizados fueron “Escala de Estilos de Crianza Parental” elaborado por Lawrence Steinberg 1991 y adaptado en Perú por Merino y Arndt (2004) y Cuestionario de Agresión (AQ) elaborado por Arnold H. Buss y Mark Perry en 1992 en estados unidos y adaptado en Perú por Matalinares en 2012. Resultados: al concluir esta investigación se encontró en los resultados que existe relación significativa donde el nivel de significancia es de 0.000. Conclusión: existe una relación directa entre ambas variables.
Adaptación y propiedades psicométricas de la Escala Sentido de Coherencia (SOC-29) en jóvenes universitarios
Authors: Torres Tapia Neftali , Quispe Hilasaca Sheyla , Quispe Mamani Alcides 
Published: July 2023

Objetivo: adaptar y analizar las propiedades psicométricas de la Escala Sentido de Coherencia (SOC- 29). Metodología: la investigación se clasifica como un estudio instrumental psicométrico, de diseño no experimental, corte transversal, enfoque cuantitativo y muestreo no probabilístico. La población de estudio consta de 500 estudiantes universitarios a los cuales se les realizó la encuesta de manera virtual. El instrumento tiene 15 ítems distribuidos en 3 dimensiones: comprensibilidad, manejabilidad y significatividad, con tipo de respuesta dicotómica. Para analizar la validez de contenido se aplicó el criterio de juicio de expertos, con la colaboración de 8 jueces quienes evaluaron la claridad, contexto, congruencia y dominio del constructo. Resultados: se obtuvo un índice por V de Aiken V= 0.91, una consistencia interna por alfa de Cronbach total de 0.702 lo que demuestra que el instrumento es confiable. El análisis factorial confirmatorio dio como resultado una medida de KMO= 0.779 y un valor Sig. < 0.00, la varianza total explicada por 3 factores logró un porcentaje acumulado de 42.1%, las cargas factoriales son mayores de .3 distribuidos en tres componentes, se concluye que el ítem 11 debe ser eliminado, ya que mejora el nivel de confiabilidad por alfa de Cronbach. Conclusión: el cuestionario tiene adecuadas propiedades psicométricas tales en validez y confiabilidad.
Strategi Coping stress pada Mahasiswa yang Mengikuti Organisasi di Fakultas Psikologi Universitas Negeri Malang
Authors: Firsthiansyah Ardan Virgianto  , Jawahiril Pranida  , Mia Ade Liana  , Muhammad Zidansyah Dwi Atmaja  , Mutia Husna Avezahra  
Published: July 2023

Students of the Faculty of Psychology, State University of Malang in semester 5 have quite heavy academic demands when compared to the previous semester and coupled with the demands of assignments from the organizational activities they participate in. There is an academic load as well as many programs and responsibilities in the organization that must be completed, so the stress level can be higher. This type of research is descriptive qualitative research using a phenomenological approach. The subjects were three psychology students who were active in organizations. Methods of data collection through interviews and observation. This study aims to gather information and find out how strategies for coping with stress on students who participate in organizations at the Faculty of Psychology, State University of Malang. The results of the study found that there were three phases that participants went through when faced with conditions that caused a sense of stress, besides that, planful problem solving, and accepting responsibility type coping strategies were the strategies most used by students who joined organizations in the psychology faculty, State University of Malang.
Abstrak
Mahasiswa Fakultas Psikologi Universitas Negeri Malang pada semester 5 memiliki tuntutan akademik yang cukup berat jika dibandingkan semester sebelumnya dan ditambah dengan tuntutan tugas dari kegiatan organisasi yang mereka ikuti. Adanya beban akademik dan juga banyaknya program dan tanggung jawab di organisasi yang harus diselesaikan, maka tingkat stres bisa menjadi lebih tinggi. Jenis penelitian ini adalah penelitian kualitatif deskriptif dengan menggunakan pendekatan fenomenologi. Subjeknya adalah tiga mahasiswa psikologi yang aktif berorganisasi. Metode pengumpulan data melalui wawancara dan observasi. Penelitian ini bertujuan untuk menggali informasi dan mengetahui bagaimana strategi coping stress pada mahasiswa yang mengikuti organisasi di fakultas psikologi Universitas Negeri Malang. Hasil penelitian menunjukkan bahwa terdapat tiga fase yang dilalui oleh partisipan ketika dihadapkan pada kondisi yang menimbulkan rasa stres, selain itu strategi coping jenis planful problem solving, dan accepting responsibility adalah strategi yang paling banyak digunakan oleh mahasiswa yang mengikuti organisasi di fakultas psikologi Universitas Negeri Malang.