bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noncanonical splice‐site variant in peripheral myelin protein 22 gene (PMP22) in a patient with hereditary neuropathy with liability to pressure palsies
Authors: Kawamoto Norifumi , Hamada Yuichi , Kobayashi Shunsuke , Naruse Hiroya , Ishiura Hiroyuki , Matsukawa Takashi , Mitsui Jun , Tsuji Shoji , Sonoo Masahiro , Toda Tatsushi 
Published: May 2023

AbstractAimHereditary neuropathy with liability to pressure palsies (HNPP) is a peripheral neuropathy with autosomal dominant inheritance. Diagnosis can be made from the characteristic abnormalities determined by nerve conduction studies (NCS), including subclinical deficits at physiological compression sites. Heterozygous deletion of the chromosome 17p11.2–p12 region including the peripheral myelin protein 22 gene (PMP22) is the cause in the majority of cases. However, the loss of function of PMP22 due to frameshift‐causing insertion/deletion, missense, nonsense, or splice‐site disrupting variants cause HNPP in some patients. We report a case of a patient diagnosed with HNPP on the basis of clinical features and the results of NCS. No deletions of PMP22 were detected by fluorescence in situ hybridization.MethodsWe performed direct nucleotide sequence analysis and identified a heterozygous variant, c.78 + 3G > T, in PMP22. Since this variant is located outside the canonical splice site at the exon 2–intron 2 junction, we investigated whether the variant causes aberrant splicing and leads to the skipping of exon 2 of PMP22 by in vitro minigene splicing assay.ResultsWe demonstrated that the c.78 + 3G > T variant causes the skipping of exon 2 and leads to loss of function of the mutant allele.ConclusionSearching for sequence variants located outside the canonical splice sites should also be considered even when deletion of PMP22 is not found in a patient with a clinical diagnosis suggesting HNPP.
Text mining in a literature review of abnormal uterine bleeding according to the FIGO classification
Authors: Ono Masanori , Hiraike Osamu , Kitahara Yoshikazu , Maekawa Ryo , Ota Ikuko , Yoshino Osamu , Takai Yasushi , Iwase Akira ,   Reproductive Endocrinology Committee in Japan Society of Obstetrics and Gynecology
Published: May 2023

AbstractAimAbnormal uterine bleeding, as proposed in 2007, is defined as unexpected uterine bleeding in women of reproductive age; the cause of the bleeding is categorized using the PALM‐COEIN system. Identifying the diagnostic and treatment modalities for each cause might be intriguing. To summarize the options for abnormal uterine bleeding assessment, we employed text‐mining analysis for each of its causes.MethodsWe analyzed abstracts based on PALM‐COEIN from PubMed and Web of Science in March 2022. The literature was divided into categories; topics about the disorders were retrieved, and covalent network analysis was conducted to find information for evaluating abnormal uterine bleeding.ResultsDiagnostic approaches for PALM included histological and image analysis, including computerized tomography, magnetic resonance imaging, sonography, and hysteroscopy. The therapeutic approaches varied according to the cause. Diagnostic approaches for COEIN were mostly medical history interviews and blood sampling, and the therapeutic approaches for COEIN were ablation, hysteroscopy, and hormonal treatment. The PALM‐COEIN classification co‐occurrence search revealed each cause's diagnostic procedures, symptoms, and treatment procedures.ConclusionOur text‐mining methodology revealed comprehensive insights, important study themes, and clinical trends for abnormal uterine bleeding. A tailored approach to medical realities is required for treating abnormal uterine bleeding properly.
Government performance, political trust, and satisfaction with democracy in Venezuela, 2016–2017
Authors: Watson Antonella , Soares Rodrigues Margarida , Lee Juheon 
Published: May 2023

AbstractSince 2015, Venezuela has been home to numerous protests, instigated mostly by people's discontent with the government and its public services. Despite the seriousness of these protests, limited studies have examined the Venezuelans’ evaluation of their government and democracy, and only a few of these studies have used quantitative analysis. To fill this gap, this article offers a snapshot of the ongoing crisis using the Americas Barometer survey data collected between 2016 and 2017. We first identified Venezuelans’ three main concerns during this time—shortage of food and necessities, economic crisis, and crime—and examined their relationships with the respondents’ trust in government and satisfaction with democracy. We found that shortages of food and necessities and increasing crime were negatively associated with Venezuelans’ trust in their government (although shortages were a more significant factor than crime). The long‐standing problem of economic crisis was not a significant factor in people's trust in the government. Furthermore, these three factors were not directly linked to Venezuelans’ satisfaction with democracy, but people who showed low levels of trust in government tended to have low satisfaction levels with Venezuelan democracy. Our results invite future studies to compare different times and contexts in Venezuela's ever‐changing political landscape.
Psychologists' representations of gender identity between Spain and Greece: A qualitative cross‐cultural study
Authors: Argyriou Konstantinos 
Published: May 2023

AbstractTrans people's relationship with mental health providers carries historical tensions. Counseling services have been tied to standardized procedures or diagnostic certification of dysphoria and gender evaluations, while other psychosocial demands have been largely disregarded. Moreover, protocols and approaches focus disproportionately on Anglo‐American frameworks, in terms of epistemic resources established to describe gender‐diverse experiences. These issues affect both representations of gender identity and attitudes toward counseling. The present study aimed to address psychologists' accounts cross‐culturally, by using qualitative data acquired through interviews with active practitioners from Spain and Greece. Eighteen qualitative semi‐structured interviews were conducted in both countries in order to delve into the narratives related to trans mental health care provision. Thematic analysis using Atlas.ti was used to systematize the data. The accounts centered on gender identity representations and attributions, attitudes toward counseling, relationship with diagnoses, psychological approaches, and competent training. Findings point to the need for all‐encompassing, obligatory training of psychologists on trans mental health, followed by situated considerations of the contextual factors that may contribute to experiencing gender diversity differently. More cross‐cultural qualitative accounts are thus encouraged, to enrich and update the upcoming trans literature on the matter.
Spatial distribution of new firms and firm‐level innovation: Evidence from Turkey
Authors: Can Karahasan Burhan 
Published: May 2023

AbstractThis paper examines the spatial distribution of new firms and tests the impact of new firms' agglomeration on firm‐level innovation. Our findings from a spatially unequal economy, Turkey, show that firms that are located in regions hosting more new firms have a higher propensity to be innovative. Moreover, we found that firms located in regions that are spatially connected to others with higher new firm formation are also more innovative. However, impact of local and spatial externalities created by agglomeration effects are conditional on the development level of regions.
Three‐dimensional stationary supersonic flows with axial symmetry in relativistic hydrodynamics
Authors: Lai Geng 
Published: May 2023

AbstractThe study of supersonic flows in relativistic hydrodynamics (RHDs) is of some interest for cosmology. This paper studies two types of three‐dimensional (3D) stationary supersonic flows with axial symmetry in RHDs: supersonic flows expanding in vacuum and supersonic flows against an infinite curved cone. To study supersonic flows expanding in vacuum, we consider a Cauchy problem for the 3D steady RHD equations with initial data that are a combination of an axisymmetric supersonic flow in a circular domain and vacuum in the remaining domain. Global existence of a piecewise smooth solution expanding in vacuum to the Cauchy problem is obtained, provided that the initial mass‐energy density is sufficiently small. When a supersonic flow arrives and hits a curved cone, a shock wave will arise around the cone. Moreover, if the vertex angle of the cone is less than a critical angle, then the shock will be attached to the vertex of the cone. We obtain the global existence of attached conical shock waves, provided that the curved cone satisfies some suitable conditions and the speed of the incoming flow is close to a limit speed.
Telehealth experiences in Canadian veterans: associations, strengths and barriers to care during the COVID-19 pandemic
Authors: Walker Deanna L , Nouri M S , Plouffe R A , Liu J J W , Le T , Forchuk C A , Gargala D , St Cyr K , Nazarov A , Richardson J D 
Published: May 2023

IntroductionIdentifying barriers to care in veteran populations is critical, as veterans face increased social isolation, relationship strains and financial insecurities. For Canadian veterans experiencing barriers to accessing healthcare, telehealth may be a promising alternative with comparable effectiveness to in-person services; however, the potential benefits and limitations of telehealth require further examination to determine its long-term utility, and to inform health policy and planning. The goal of the present research was to identify predictors and barriers to telehealth usage in Canadian veterans in the context of the COVID-19 pandemic.MethodsData were drawn from baseline data of a longitudinal survey examining the psychological functioning of Canadian veterans during the COVID-19 pandemic. Participants were 1144 Canadian veterans aged 18–93 years (Mage=56.24, SD=12.92; 77.4% men). We assessed reported telehealth use (ie, for mental healthcare, physical healthcare), healthcare access (ie, difficulty accessing care, avoidance of care) and mental health and stress since the beginning of the COVID-19 pandemic, sociodemographic variables and open-ended responses about telehealth experiences.ResultsFindings suggest that sociodemographic factors and previous telehealth use were significantly associated with telehealth use during the COVID-19 pandemic. Qualitative evidence highlighted both the benefits (eg, reducing barriers of access) and drawbacks (eg, not all services can be delivered) of telehealth services.ConclusionsThis paper provided a deeper understanding of Canadian veterans’ experiences with accessing telehealth care during the COVID-19 pandemic. While for some, the use of telehealth mitigated perceived barriers (eg, safety concerns of leaving home), others felt that not all health services could be appropriately carried out through telehealth. Altogether, findings support the use of telehealth services in increasing care accessibility for Canadian veterans. Continued use of quality telehealth services may be a valuable form of care that extends the reach of healthcare professionals.
Integrative oncology in cancer care – implementation factors: mixed-methods systematic review
Authors: Kwong Ming Hong , Ho Leonard , Li Angus S C , Nilsen Per , Ho Fai Fai , Zhong Claire C W , Chung Vincent C H 
Published: May 2023

BackgroundIntegrative oncology (IO) appears to be beneficial to patients with cancer, but its implementation remains a challenge. Guided by the Theoretical Domains Framework (TDF) and the Capability–Opportunity–Motivation–Behaviour (COM-B) model, this systematic review identified the barriers to and facilitators of IO implementation in conventional cancer care settings.MethodsWe searched eight electronic databases from their inception until February 2022 for qualitative, quantitative or mixed-methods empirical studies reporting the implementation outcomes for IO services. Critical appraisal approach was tailored according to study types. The identified implementation barriers and facilitators were mapped onto TDF domains and the COM-B model, and subsequently onto the behavioural change wheel (BCW) for formulating behavioural change interventions.ResultsWe included 28 studies (11 qualitative, 6 quantitative, 9 mixed-methods and 2 Delphi studies) of satisfied methodological quality. The main implementation barriers were the lack of IO knowledge, the absence of funding and healthcare professionals’ low level of IO receptiveness. The key implementation facilitators were the dissemination of evidence on IO clinical benefits, the equipping of professionals with IO service delivery skills and the provision of a supportive organisational climate.ConclusionMultifaceted implementation strategies are needed to address the determinants influencing IO service delivery. Based on our BCW-based analysis of the included studies, the keybehavioural change techniquesare: (1) educating healthcare professionals about the value and application of traditional and complementary medicine; (2) ensuring access to actionable clinical evidence on IO effectiveness and safety and (3) designing guidelines on communicating traditional and complementary medicine interventions with patients and caregivers for biomedically trained doctors and nurses.
Changes in infectious agent profiles and host gene expression during spawning migrations of adult sockeye salmon (Oncorhynchus nerka)
Authors: Elmer Laura K. , Bass Arthur L. , Johnston Stephen D. , Kaukinen Karia H. , Kelly Lisa A. , Li Shaorong , Teffer Amy K. , Miller Kristi M. , Cooke Steven J. , Hinch Scott G. 
Published: May 2023

During spawning migrations, adult Pacific salmon ( Onco rhynchus spp.) must undergo a suite of morphological and physiological changes to prepare for spawning. Modern genomics approaches can be used to conduct nonlethal assessments of physiology and infectious agent presence in migrating salmon. We investigated gene expression changes and shifts in the prevalence and load of 18 infectious agents in the gill tissue of adult sockeye salmon ( Oncorhynchus nerka) during the final 50 km of their freshwater migration. We found 77% of fish successfully migrated to spawning grounds. Fish exhibited a decrease in thermal stress gene expression following lake migration, consistent with the hypothesized benefits of thermal refugia during spawning migrations. We also found evidence of cooler water selection (∼1.5 °C) during lake migration for fish with higher infection burden, suggesting behavioural changes for fish suffering higher infection burdens and potential benefits of thermal refuges for reducing the negative impacts of infection for migrating salmon. Collectively, our findings provide further evidence that fish behaviourally regulate exposure to stressful conditions such as high temperature that may undermine survival.
ALBA Synchrotron and its future
Authors: Biscari C. , Aigner E. , Attenkofer K. , Casas J. , Ferrer S. , Matilla O. , Nicolas J. , Pascual R. , Pérez F. , Pont M. , Sánchez A. 
Published: May 2023

AbstractThe ALBA Synchrotron light source is the Spanish national facility, providing extended research capabilities and a wide range of state-of-the-art instrumentation to academic and industrial users of the Spanish and European Research Area since 2012. It includes ten operating beamlines, two beamlines in commissioning and two more in construction. JEMCA (Joint Electron Microscopy Center at ALBA), a center including advanced electron microscopes, developed in collaboration with partner institutions, has recently been inaugurated. The next years will be dedicated to exploit the existing instrumentation, and in parallel prepare the upgrade toward a fourth generation synchrotron source, by combining the partial substitution of the accelerators with the upgrade of the existing instrumentation, the addition of new cutting-edge beamlines, the development of further capabilities for automatization, simulation, prototyping, nanotechnology and advanced optics, and the extension of the infrastructure in the nearby plots, which will host the new long beamline end-stations and aim at being the seed of a science, technology and innovation park. The 2-year dark period is foreseen for the end of this decade. The status of the facility, few scientific highlights, and the plans for the future are described.
Load-optimization in Reconfigurable Data-center Networks: Algorithms and Complexity of Flow Routing
Authors: Dai Wenkai , Foerster Klaus-Tycho , Fuchssteiner David , Schmid Stefan 
Published: May 2023

Emerging reconfigurable data centers introduce unprecedented flexibility in how the physical layer can be programmed to adapt to current traffic demands. These reconfigurable topologies are commonly hybrid, consisting of static and reconfigurable links, enabled by e.g., an Optical Circuit Switch (OCS) connected to top-of-rack switches in Clos networks. Even though prior work has showcased the practical benefits of hybrid networks, several crucial performance aspects are not well understood. For example, many systems enforce artificial segregation of the hybrid network parts, leaving money on the table.
In this article, we study the algorithmic problem of how to jointly optimize topology and routing in reconfigurable data centers, in order to optimize a most fundamental metric, maximum link load. The complexity of reconfiguration mechanisms in this space is unexplored at large, especially for the following cross-layer network-design problem: given a hybrid network and a traffic matrix, jointly design the physical layer and the flow routing in order to minimize the maximum link load.
We chart the corresponding algorithmic landscape in our work, investigating both un-/splittable flows and (non-)segregated routing policies. A topological complexity classification of the problem reveals NP-hardness in general for network topologies that are trees of depth at least two, in contrast to the tractability on trees of depth one. We moreover prove that the problem is not submodular for all these routing policies, even in multi-layer trees.
However, networks that can be abstracted by a single packet switch (e.g., nonblocking Fat-Tree topologies) can be optimized efficiently, and we present optimal polynomial-time algorithms accordingly. We complement our theoretical results with trace-driven simulation studies, where our algorithms can significantly improve the network load in comparison to the state-of-the-art.
Blurred Lines or Spatial Clustering? Assessing the Association between Peacekeeping Presence and Attacks against Humanitarians in Darfur
Authors: Duursma Allard , Fast Larissa , Read Róisín 
Published: May 2023

Abstract
A prominent explanation of the rising attacks on aid workers is that aid workers in proximity to peacekeepers or soldiers of an intervention force are seen to be associated with them. This article leverages high-quality, disaggregated data collected by the UN about attacks on humanitarians in Darfur between January 2008 and March 2009 to examine this “blurring of the lines” explantion. We argue that rather than a blurred lines logic, spatial clustering of peacekeepers and humanitarians in a given area explains why aid workers are often attacked in proximity to peacekeepers. Consistent with this argument, we find that when controlling for humanitarian activity, the number of peacekeepers in an area is no longer significantly associated with attacks on aid workers. This study has important implications for current discussions on the relationship between humanitarians and peacekeepers and the concept of humanitarian space.
The Second Edition of the South Commission
Authors: Abdenur Adriana Erthal 
Published: May 2023

Abstract
This essay proposes the creation of a second edition of the South Commission, with updated discussions featuring not only the central theme of development, but also the topics of climate and environment as part of joint efforts to achieve an overarching diagnosis of key challenges facing humankind – with a focus on the developing world – as well as a roadmap for global governance reform that takes both historical and current demands seriously and that shields, even if partially, key global governance institutions, including the UN system, from global power politics. While building bridges with the North is necessary, without a South-led reform agenda, global governance will remain undemocratic, unjust, and ineffective.
Casting and Casteing Indian Diplomacy
Authors: Thakur Vineet 
Published: May 2023

Abstract
In this essay, I look at a curious intersection – the emergence of Indian diplomacy in the interwar era and the end of indentured labor. A genealogical reading suggests that Indian diplomacy takes “birth” primarily to articulate the political and civic rights of the new, seemingly upper caste Indian, in contrast to the lower caste “coolie” of the past. Diplomacy here becomes a practice through which this difference between the upper caste Indian migrant as a rights-bearing individual, and the lower caste Indian migrant as a non-rights bearing individual is enacted. This interrogation of Indian diplomatic practice is primarily an effort to reveal the ways in which caste, rarely explored as a factor in Indian diplomacy, is indeed central to its making.
Fundamental Constitutional Changes Without Participation of the Constituent Power
Authors: Mayieka Oira Nickson 
Published: May 2023

Abstract
The book review analyzes the work of two renowned scholars who have highlighted how fundamental constitutional amendments could take place through interpretation of statutes by the judicial arm of government or through legislation without invoking the formal constitutional amendment processes. Such constitutional changes are fundamental and therefore transform the polity of a society without involving the constituent power. It is crystal clear from the authors that constitutional revolution is not so much about the process of change but about the significance of the changes made.