bluuebunny/crossref_metadata_2025_split huggingface dataset:
Framework for sustainable value creation: a synthesis of fragmented sustainable business model literature
Authors: Manninen Kaisa , Laukkanen Minttu , Huiskonen Janne 
Published: July 2023

Purpose
This study aims to synthesize the body of sustainable value creation (SVC) research within sustainable business model literature through a systematic literature review.

Design/methodology/approach
A systematic literature review of 85 research articles of SVC through business models from 2011 to 2020.

Findings
The systematic literature review allowed the authors to identify five core SVC elements: value forms, stakeholders, temporal view, spatial view and tensions and conflicts. Moreover, a conceptual framework presenting the interrelationships of the SVC elements is proposed.

Practical implications
This study carries implications for practitioners in the form of guiding questions provided in the framework. Those questions help responsible managers to plan, identify and choose strategic sustainability actions and to develop companies’ business models aiming to lead to the creation of long-term sustainable value in different time frames and locations or different parts of the value network. Additionally, the framework guides managers to identify and manage potential tensions and conflicts which can otherwise hinder SVC.

Originality/value
To the best of the authors’ knowledge, this study is the first systematic literature review of SVC through business models with the conceptual development of SVC. The study synthesizes the fragmented literature to identify SVC elements and build basis for conceptualization of SVC through business models.
Essential 3: professional learning in the context of PDS’ and school-university partnerships
Authors: Polly Drew , Badiali Bernard , Burns Rebecca West , Coler Cynthia , Cosenza Michael , Goree Krystal , Stoicovy Donnan , Zenkov Kristien 
Published: July 2023

PurposeThe purpose of this article is to provide a description as well as examples related to Essential 3 in the Second Edition of the NAPDS Nine Essentials.
Regional resilience and the role of cooperative firms
Authors: Costa Michele , Delbono Flavio 
Published: July 2023

Purpose
This paper aims to investigate the impact of cooperative firms on the patterns of regional economic resilience in Italy from 2008 to 2019.

Design/methodology/approach
This study uses regional statistics to compute indices of resilience for both real GDP per capita and employment during both recovery and resistance periods. By means of a linear model, the authors investigate the relationships between indices of resilience and the cooperative presence, while controlling for a set of demographic, social and economic variables.

Findings
This study shows that during (and after) recessions such regional indices exhibit very different patterns, with notably poorer performance observed in Southern regions compared to the rest of the country. Furthermore, this study illustrates that the size of the cooperative employment improves the overall resilience of regional employment, especially during recovery periods.

Social implications
The findings hint at policies enhancing the strength and scope of the cooperative movement as a driver of territorial resilience.

Originality/value
To the best of the authors’ knowledge, this is the first study in relating territorial resilience and the presence of a type of companies. This study performs the analysis at the regional level regarding cooperative enterprises. The new findings hint at some policies enhancing the strength and scope of the cooperative movement.
Widespread amphibian Perkinsea infections associated with Ranidae hosts, cooler months and Ranavirus co‐infection
Authors: Atkinson Matthew S. , Savage Anna E. 
Published: July 2023

AbstractAmphibians suffer from large‐scale population declines globally, and emerging infectious diseases contribute heavily to these declines. Amphibian Perkinsea (Pr) is a worldwide anuran pathogen associated with mass mortality events, yet little is known about its epidemiological patterns, especially in comparison to the body of literature on amphibian chytridiomycosis and ranavirosis.Here, we establish Pr infection patterns in natural anuran populations and identify important covariates including climate, host attributes and co‐infection with Ranavirus (Rv).We used quantitative (q)PCR to determine the presence and intensity of Pr and Rv across 1234 individuals sampled throughout central Florida in 2017–2019. We then implemented random forest ensemble learning models to predict infection with both pathogens based on physiological and environmental characteristics.Perkinsea infected 32% of all sampled anurans, and Pr prevalence was significantly elevated in Ranidae frogs, cooler months, metamorphosed individuals and frogs co‐infected with Rv, while Pr intensity was significantly higher in ranid frogs and individuals collected dead. Ranavirus prevalence was 17% overall and was significantly higher in Ranidae frogs, metamorphosed individuals, locations with higher average temperatures, and individuals co‐infected with Pr. Perkinsea prevalence was significantly higher than Rv prevalence across months, regions, life stages and species. Among locations, Pr prevalence was negatively associated with crayfish prevalence and positively associated with relative abundance of microhylids, but Rv prevalence did not associate with any tested co‐variates. Co‐infections were significantly more common than single infections for both pathogens, and we propose that Pr infections may propel Rv infections because seasonal Rv infection peaks followed Pr infection peaks and random forest models found Pr intensity was a leading factor explaining Rv infections.Our study elucidates epidemiological patterns of Pr in Florida and suggests that Pr may be under‐recognized as a cause of anuran declines, especially in the context of pathogen co‐infection.
Issuer Motivations for Corporate Green Bond Offerings
Authors: Dutordoir Marie , Li Shuyu , Neto João Quariguasi Frota 
Published: July 2023

AbstractDespite the substantial increase in green bond issuance over the past decade, evidence on the drivers and costs of corporate green bond issuance is lacking. We develop four novel hypotheses on the determinants of firms’ choice between green and conventional bonds, by connecting the four distinct features of green bonds with relevant theories. We test these hypotheses on a sample of green and conventional bonds issued by US, Western European and Chinese firms between 2014 and 2021, using linear probability models and alternative approaches. Consistent with our hypotheses, we find that firms with higher reputational gains from being seen as green and a stronger focus on eco‐innovation are more likely to issue green instead of conventional bonds. Conversely, we obtain only limited evidence that green bond issuance is driven by the net benefits of additional disclosure and no evidence that green bond issuers cater to time‐varying investor preferences for corporate greenness. Our results, which survive several robustness tests, are relevant for corporate managers, investors and bond market regulators.
Untangling human resource management and employee wellbeing relationships: Differentiating job resource HR practices from challenge demand HR practices
Authors: Li Mengwei , Fu Na , Chadwick Clint , Harney Brian 
Published: July 2023

AbstractIn the strategic HR literature, current empirical results on the relationship between HR practices and employee wellbeing are mixed and contradictory. Based on the job resources and demands model and the fine‐tuned challenge‐hindrance demands framework, we propose that an important reason lies in the lack of attention paid to the different characteristics of HR practices. HR practices can serve as either job resources or challenge demands to employees, thereby having differential effects on the psychological, physical, and social dimensions of wellbeing. We integrate a measure of challenge demand (including time pressure and workload) as a mediator to further reveal how these different categories of HR practices influence employee wellbeing. Using structural equation modeling in a dataset of 4823 individual workers from a National Workplace Survey of Employees conducted in Ireland, we find that job resource HR practices are positively associated with all three dimensions of wellbeing both directly and indirectly, while challenge demand HR practices are positively associated with psychological wellbeing but negatively associated with physical wellbeing and social wellbeing primarily through the mediating effect of time pressure and workload. These findings point to important variable relationships, reinforcing the need to untangle the HRM employee wellbeing relationship beyond aggregated and uniform HRM‐wellbeing assertions.
Teaching through the cloud: An ethnography of the role of cloud‐based collaborative technologies in the formation of teachers' classroom practices
Authors: Unsworth Ruth 
Published: July 2023

AbstractThrough an examination of ethnographic fieldwork data, this paper explores the ways in which cloud‐based collaborative technologies created by Google mediate (Latour 1994) teachers' discussions around, agreement of and enactments of their classroom practices. Bringing together concepts from actor‐network theory and literacy studies, this paper argues for greater consideration of the role(s) of increasingly‐used technologies in shaping teachers' practices and suggests a framework for exploring this issue further.
The double‐edged sword of employee forgiveness: How forgiveness motives steer forgiveness toward interpersonal citizenship behaviors and interpersonal deviance
Authors: Zhang Junwei , Zhang Yajun , Lu Lu 
Published: July 2023

AbstractPrevious research has almost universally shown that forgiveness is a beneficial virtue that can generate a series of positive outcomes. We challenge this prevailing view by proposing that employee forgiveness is a mixed blessing. Setting off from distinguishing the motives behind forgiveness, we integrated the relational perspective and ego depletion theory to explore the beneficial and detrimental consequences of employee forgiveness. Specifically, our study investigated when and how employee forgiveness leads to interpersonal citizenship behaviors (ICBs) and interpersonal deviance. Using a sample of 349 supervisor–employee dyads, we found that employee forgiveness driven by strong relationship‐oriented motives could foster high‐quality relationships with coworkers and facilitate ICBs. In contrast, employee forgiveness driven by strong self‐oriented motives could cause more resource depletion and increase interpersonal deviance. Furthermore, we discuss the theoretical and practical implications of our study as well as future research directions.
Adopting telework: The causal impact of working from home on subjective well‐being
Authors: Gueguen Guillaume , Senik Claudia 
Published: July 2023

AbstractWe study the impact of work from home (WFH) on subjective well‐being during the Covid period, where self‐selection of individuals into telework is ruled out, at least part of the time, by stay‐at‐home orders. We use a difference‐in‐differences approach with individual fixed effects and identify the specific impact of switching to telecommuting, separately from any other confounding factor. In particular, our identification strategy avoids the influence of interpersonal heterogeneity by exploiting the multiple entries into WFH, by the same individuals, at different times. On average over the period, switching to WFH, especially full‐time, worsens mental health. We also find a positive but imprecisely measured impact of part‐time WFH on life satisfaction. However, this hides a dynamic evolution, whereby the initial deterioration gives place to an adaptation process after a couple of months. We also uncover a particularly pronounced fall in subjective well‐being of women with children, especially in the first months; this could be associated with home‐schooling.
Connection between oxidative stress and subcellular organelle in subarachnoid hemorrhage: Novel mechanisms and therapeutic implications
Authors: Zhang Jiahao , Zhang Zeyu , Wang Xiaoyu , Liu Yibo , Yu Qian , Wang Kaikai , Fang Yuanjian , Lenahan Cameron , Chen Maohua , Chen Sheng 
Published: July 2023

AbstractSpontaneous subarachnoid hemorrhage (SAH) is one of the most devastating forms of stroke, with limited treatment modalities and poor patient outcomes. Previous studies have proposed multiple prognostic factors; however, relative research on treatment has not yet yielded favorable clinical outcomes. Moreover, recent studies have suggested that early brain injury (EBI) occurring within 72 h after SAH may contribute to its poor clinical outcomes. Oxidative stress is recognized as one of the main mechanisms of EBI, which causes damage to various subcellular organelles, including the mitochondria, nucleus, endoplasmic reticulum (ER), and lysosomes. This could lead to significant impairment of numerous cellular functions, such as energy supply, protein synthesis, and autophagy, which may directly contribute to the development of EBI and poor long‐term prognostic outcomes. In this review, the mechanisms underlying the connection between oxidative stress and subcellular organelles after SAH are discussed, and promising therapeutic options based on these mechanisms are summarized.
Cost‐effectiveness of canagliflozin and dapagliflozin for treatment of patients with chronic kidney disease and type 2 diabetes
Authors: Nguyen Bao‐Ngoc , Mital Shweta , Bugden Shawn , Nguyen Hai V. 
Published: July 2023

AbstractAimTo examine the cost‐effectiveness of adding canagliflozin or dapagliflozin to standard of care (SoC) versus SoC alone in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D).Materials and MethodsWe used a Markov microsimulation model to assess the cost‐effectiveness of canagliflozin plus SoC (canagliflozin + SoC), dapagliflozin plus SoC (dapagliflozin + SoC) and SoC alone. Analyses were conducted from a healthcare system perspective. Costs were measured in 2021 Canadian dollars (C$), and effectiveness was measured in quality‐adjusted life‐years (QALYs).ResultsOver a patient's lifetime, canagliflozin + SoC and dapagliflozin + SoC yielded cost savings of C$33 460 and C$26 764 and generated 1.38 and 1.44 additional QALYs compared with SoC alone, respectively. While QALY gains with dapagliflozin + SoC were higher than those with canagliflozin + SoC, this strategy was also more costly with the incremental cost‐effectiveness ratio exceeding the willingness to pay threshold of C$50 000 per QALY. Dapagliflozin + SoC, however, generated cost savings and QALY gains compared with canagliflozin + SoC over shorter time horizons of 5 or 10 years.ConclusionsDapagliflozin + SoC was not cost‐effective versus canagliflozin + SoC in patients with CKD and T2D over the lifetime horizon. However, adding canagliflozin or dapagliflozin to SoC was less costly and more effective relative to SoC alone for treatment of CKD and T2D.
Comparison of physicochemical and functional characteristics of insoluble dietary fibre from okara by separate and co‐fermentation with lactic acid bacteria and Kluyveromyces marxianus
Authors: Yue Yang , Li Yunbo , Li Pengcheng , Xiao Yuyi , Piao Chunhong , Wang Xiujuan 
Published: July 2023

SummaryOkara, a natural source of dietary fibre (DF), is recognised as an edible and safe material. In this study, lactic acid bacteria (LAB) and Kluyveromyces marxianus were used to ferment okara in separately or in combination, and the physicochemical and functional characteristics of obtained insoluble dietary fibre (IDF) excluded from okara were compared. The result showed that compared with non‐fermented okara, the content of IDF from co‐fermented okara by LAB and K. marxianus increased by 6.8%, while separate fermentations were 2.4% and 4.0%. Scanning electron microscopy result showed that the structure of co‐fermented okara IDF was looser and porous with the edge disappeared compared to separate and non‐fermented okara. All the fermentation treatment groups effectively reduced the particle size and affected the cellulose and hemicellulose functional groups of IDF. Furthermore, compared with non‐fermented okara, processing performance, and the activities of hypoglycaemic and hypolipidaemic of IDF were greatly improved in fermented okara.
Spatiotemporally programming cytokine immunotherapies through protein engineering
Authors: Santollani Luciano , Wittrup K. Dane 
Published: July 2023

SummaryCytokines have long been considered promising cancer immunotherapy agents due to their endogenous role in activating and proliferating lymphocytes. However, since the initial FDA approvals of Interleukin‐2 (IL‐2) and Interferon‐ɑ (IFNɑ) for oncology over 30 years ago, cytokines have achieved little success in the clinic due to narrow therapeutic windows and dose‐limiting toxicities. This is attributable to the discrepancy between the localized, regulated manner in which cytokines are deployed endogenously versus the systemic, untargeted administration used to date in most exogenous cytokine therapies. Furthermore, cytokines' ability to stimulate multiple cell types, often with paradoxical effects, may present significant challenges for their translation into effective therapies. Recently, protein engineering has emerged as a tool to address the shortcomings of first‐generation cytokine therapies. In this perspective, we contextualize cytokine engineering strategies such as partial agonism, conditional activation and intratumoral retention through the lens of spatiotemporal regulation. By controlling the time, place, specificity, and duration of cytokine signaling, protein engineering can allow exogenous cytokine therapies to more closely approach their endogenous exposure profile, ultimately moving us closer to unlocking their full therapeutic potential.
Classification and characterisation of extracellular vesicles‐related tuberculosis subgroups and immune cell profiles
Authors: Zhou Peipei , Shen Jie , Ge Xiao , Ding Fang , Zhang Hong , Huang Xinlin , Zhao Chao , Li Meng , Li Zhenpeng 
Published: July 2023

AbstractAround the world, tuberculosis (TB) remains one of the most common causes of morbidity and mortality. The molecular mechanism ofMycobacterium tuberculosis(Mtb) infection is still unclear. Extracellular vesicles (EVs) play a key role in the onset and progression of many disease states and can serve as effective biomarkers or therapeutic targets for the identification and treatment of TB patients. We analysed the expression profile to better clarify the EVs characteristics of TB and explored potential diagnostic markers to distinguish TB from healthy control (HC). Twenty EVs‐related differentially expressed genes (DEGs) were identified, and 17 EVs‐related DEGs were up‐regulated and three DEGs were down‐regulated in TB samples, which were related to immune cells. Using machine learning, a nine EVs‐related gene signature was identified and two EVs‐related subclusters were defined. The single‐cell RNA sequence (scRNA‐seq) analysis further confirmed that these hub genes might play important roles in TB pathogenesis. The nine EVs‐related hub genes had excellent diagnostic values and accurately estimated TB progression. TB's high‐risk group had significantly enriched immune‐related pathways, and there were substantial variations in immunity across different groups. Furthermore, five potential drugs were predicted for TB using CMap database. Based on the EVs‐related gene signature, the TB risk model was established through a comprehensive analysis of different EV patterns, which can accurately predict TB. These genes could be used as novel biomarkers to distinguish TB from HC. These findings lay the foundation for further research and design of new therapeutic interventions aimed at treating this deadly infectious disease.
Environmental oestrogens disrupt testicular descent and damage male reproductive health: Mechanistic insight
Authors: Li Danli , Ping Hongyan , Li Ke , Lin Junjie , Jiang Xuewu , Zhang Xuan 
Published: July 2023

AbstractEnvironmental oestrogens (EEs) as environmental pollutants have been paid much attention due to their impact on congenital malformation of male genitourinary system. Exposure to EEs for prolonged time could hinder testicular descent and cause testicular dysgenesis syndrome. Therefore, it is urgent to understand the mechanisms by which EEs exposure disrupt testicular descent. In this review, we summarize recent advances in our understanding of the process of testicular descent, which is regulated by intricate cellular and molecular networks. Increasing numbers of the components of these networks such as CSL and INSL3 are being identified, highlighting that testicular descent is a highly orchestrated process that is essential to human reproduction and survival. The exposure to EEs would lead to the imbalanced regulation of the networks and cause testicular dysgenesis syndrome such as cryptorchidism, hypospadias, hypogonadism, poor semen quality and testicular cancer. Fortunately, the identification of the components of these networks provides us the opportunity to prevent and treat EEs induced male reproductive dysfunction. The pathways that play an important role in the regulation of testicular descent are promising targets for the treatment of testicular dysgenesis syndrome.
Endoplasmic reticulum homeostasis—From molecules to organisms: Report on the 14th International Calreticulin Workshop, Saint Malo, France
Authors: Bakambamba Ketsia , Di Modugno Federico , Guilbard Marianne , Le Goupil Simon , Lhomond Stephanie , Pelizzari‐Raymundo Diana , Avril Tony , Chevet Eric , Delom Frédéric , Lafont Elodie 
Published: July 2023

AbstractThe Calreticulin Workshop, initiated in 1994 by Marek Michalak in Banff (Alberta, Canada), was first organized to be an informal scientific meeting attended by researchers working on diverse biological questions related to functions associated with the endoplasmic reticulum (ER)‐resident lectin‐like chaperone and applied to a wide range of biological systems and models. Since then, this workshop has broadened the range of topics to cover all ER‐related functions, has become international and has been held in Canada, Chile, Denmark, Italy, Switzerland, UK, USA, Greece and this year in France. Each conference, which is organized every other year (pending world‐wide pandemic), generally attracts between 50 and 100 participants, including both early career researchers and international scientific leaders to favour discussions and exchanges. Over the years, the International Calreticulin Workshop has become an important gathering of the calreticulin and ER communities as a whole. The 14th International Calreticulin Workshop occurred from May 9–12 in St‐Malo, Brittany, France, and has been highlighted by its rich scientific content and open‐minded discussions held in a benevolent atmosphere. The 15th International Calreticulin Workshop will be organized in 2025 in Brussels, Belgium.