bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time profile measurement method for a large-scale satellite antenna
Authors: Fang Zheng , Wang Yaru , Liu Yang , Lv Liangliang , Fang Guangqiang , Lv Zeqian , Gao Zeren , Su Yong , Zhang Qingchuan 
Published: February 2023

To improve the detection capability of satellite-based synthetic aperture radar, a
large antenna array with a length scale of 100 meters is urgently
needed. However, the structural deformation of the large antenna leads
to phase errors, which will significantly reduce the antenna gain;
hence, real-time and high-precision profile measurements of the
antenna are essential for active compensation of the phase and thus
improving the antenna gain. Nevertheless, the conditions of antenna
in-orbit measurements are rather severe because of limited
installation locations of measurement instruments, large areas, and
long distance to be measured, and unstable measurement environments.
To deal with the issues, we propose a three-dimensional displacement
measurement method for the antenna plate based on laser distance
measuring and digital image correlation (DIC). The proposed method
uses the DIC method to retrieve the in-plane displacement information
in combination with a laser range finder to provide depth information.
A Scheimpflug camera is used to overcome the limitation of the depth
of field of traditional cameras and enable clear imaging of the full
field. Moreover, a vibration compensation scheme is proposed to
eliminate the measurement error of the target displacement caused by
the random vibration (within 0.01°) of the camera support rod. The
results of the experiment in a laboratory setting show that the
proposed method can effectively eliminate the measurement error caused
by camera vibration (50 mm) and reduce the displacement
measurement error to within 1 mm with a measurement range of
60 m, which can meet the measurement requirements of
next-generation large satellite antennas.
Interpreting T-cell search “strategies” in the light of evolution under constraints
Authors: Wortel Inge M. N. , Textor Johannes 
Published: February 2023

Two decades of in vivo imaging have revealed how diverse T-cell motion patterns can be. Such recordings have sparked the notion of search “strategies”: T cells may have evolved ways to search for antigen efficiently depending on the task at hand. Mathematical models have indeed confirmed that several observed T-cell migration patterns resemble a theoretical optimum; for example, frequent turning, stop-and-go motion, or alternating short and long motile runs have all been interpreted as deliberately tuned behaviours, optimising the cell’s chance of finding antigen. But the same behaviours could also arise simply because T cells cannot follow a straight, regular path through the tight spaces they navigate. Even if T cells do follow a theoretically optimal pattern, the question remains: which parts of that pattern have truly been evolved for search, and which merely reflect constraints from the cell’s migration machinery and surroundings?
We here employ an approach from the field of evolutionary biology to examine how cells might evolve search strategies under realistic constraints. Using a cellular Potts model (CPM), where motion arises from intracellular dynamics interacting with cell shape and a constraining environment, we simulate evolutionary optimization of a simple task: explore as much area as possible. We find that our simulated cells indeed evolve their motility patterns. But the evolved behaviors are not shaped solely by what is functionally optimal; importantly, they also reflect mechanistic constraints. Cells in our model evolve several motility characteristics previously attributed to search optimisation—even though these features are not beneficial for the task given here. Our results stress that search patterns may evolve for other reasons than being “optimal”. In part, they may be the inevitable side effects of interactions between cell shape, intracellular dynamics, and the diverse environments T cells face in vivo.
Mental health, risk perception, and coping strategies among healthcare workers in Egypt during the COVID-19 pandemic
Authors: Elsayed Mohamed E. G. , El-Abasiri Radwa Abdullah , Marzo Roy Rillera , Dardeer Khaled T. , Kamal Manar Ahmed , Abdelaziz Heba , Soliman Soliman Belal , Htay Mila Nu Nu 
Published: February 2023

Background
Coronavirus disease-19 emerged in December 2019. Healthcare workers were exposed to this highly infectious virus during the pandemic and suffered several social and psychological consequences, such as anxiety, psychological distress, and burnout.

Objectives
To assess the psychological distress, anxiety, depression, coping strategies, risk perception, and attitude toward interprofessional teamwork among Egyptian healthcare workers during the COVID-19 pandemic.

Methods
We conducted a cross-sectional online survey which consisted of five sections. The primary outcomes were anxiety (GAD-7), depression (PHQ-9), risk perception towards COVID-19, interprofessional teamwork attitude, and coping strategies during the Coronavirus disease-19 pandemic. The web-based questionnaire was distributed to Egyptian healthcare workers from the 20th of April 2020 to the 20th of May 2020. A snowball sampling method was used. Regression analysis was conducted to test the relationship between the socioeconomic characteristics and the previously mentioned outcomes.

Results
A total of 403 participants responded to the online questionnaire. The majority were females (70.5%) and within the age group of 26–40 years (77.7%), with 2–5 years of work experience (43.2%). Most participants were pharmacists (33%) and physicians (22.1%). Eighty-two participants (21%) reported moderate to severe anxiety, and 79 participants reported (19.4%) moderate to severe depressive symptoms. In the univariate model, the marital status was associated with depression (OR 0.47, 95% CI 0.28–0.78), anxiety (OR 0.52, 95% CI 0.32–0.85), and an attitude toward interprofessional teamwork (β = -1.96 95% CI -2.72 to -1.2). Providing direct care to the patients was associated with lower anxiety symptoms (AOR 0.256, 95% CI 0.094–0.697). More severe anxiety and depressive symptoms were associated with difficulties in everyday life and the professional work environment (AOR 4.246 and 3.3, P = 0.003 and 0.01, respectively). Availability of mental health facilities at the workplace was associated with a lower risk perception towards COVID-19 (β = -0.79, 95% CI -1.24 to -0.34) and a more positive attitude towards teamwork (β = 2.77 95% CI 1.38–4.15).

Conclusions
According to our results, the COVID-19 pandemic was associated with mild anxiety and depression among healthcare workers in Egypt, especially pharmacists and physicians. We recommend more research targeting the mental health of healthcare workers in Egypt. If proven cost-effective and needed, wide-scale mental health screening and public health campaigns can facilitate effective prevention and treatment strategies. In addition, the availability of mental health facilities at the workplace could alleviate some of the risk perception associated with health emergencies and improve interprofessional teamwork.
Can We Use Our Dental Curing Lights to Polymerize Objects Produced with 3D Resin Printer?
Authors: Türkay Kölüş  , Mehmet Şahbaz  , Uğur Köklü  
Published: February 2023

BACKGROUND
Dental treatment objects produced with 3D resin printers barely polymerize after fabrication. They need post-curing and an extra polymerization oven is required. Present study is aimed to determine the effectiveness of dental curing lights for post-curing of objects produced with a 3D resin printer.
METHODS
Samples were produced with Alias ​​Sharp & Rigid Model 3D Printing Resin in Photon Mono X 3D resin printer. The control set samples were cured with UV light for 2 min in Wash & Cure Plus device. T-20, T-40 and T-60 set samples were exposed to VALO Cordless curing light for 20, 40 and 60 seconds respectively. The hardness was measured with the Shore D Durometer. Then, the samples were subjected to compression. For statistical analysis, one way analysis of variance (ANOVA) and Tukey test was used.
RESULTS
The set cured with VALO Cordless for 20 seconds showed the highest strength. Compressive strength decreased with prolongation of the curing time. All experimental sets showed significantly higher hardness than the control set. Hardness increased gradually in the 20 and 40 second sets, but the difference between the 40 and 60 second sets was not significant. Also, color change was observed in the experimental sets samples.
CONCLUSIONS
Dental curing lights are effective in post-curing 3D printer resins.
Morphologic and Topographic Anatomy of the Nutrient Foramen in Human Long Bones and Its Clinical Significance
Authors: Gamze Taşkin Şenol  , Ibrahim Kürtül  
Published: February 2023

BACKGROUND
The aim of the study was to evaluate the number and position of the nutrient foramina in tibia, fibula, femur, humerus, ulna, and radius bones of dry human bones and correlate the results clinically.
METHODS
For this purpose, 214 long bones were examined. Of the 214 bones studied, 31 were radial, 28 ulnar, 46 humeral, 33 tibial, 22 fibular and 54 femoral. The size, location and the number of nutrient foramina were analysed, and the length of the bone, and the distance of the nutrient foramina from the proximal end of the bone were measured. And the foraminal index was calculated.
RESULTS
The numbers of primary nutrient foramen (PF) and secondary nutrient foramen (SF) were 183 (85.5 %) and 16 (7.47 %), respectively, and distributed 80.64 % at radius, 92.85 % at ulna, 80.43 % at humerus, 93.93 % at tibia, 86.36 % at fibula, and 83.33 % at femur. The greatest number of SF was on the femur, but not on the tibia and fibula. A statistically significant correlation was seen among; TL-DPF (radius, tibia and femur), DPF-FI (radius, ulna, humerus, tibia, fibula and femur).
CONCLUSIONS
This study provides important information about the morphology of nutrient foramina in human long bones, knowledge of which will be useful to surgeons in planning orthopaedic procedures and useful to anthropologists in segmental analysis.
Prevalence of Influenza Virus in Patients with Severe Acute Respiratory Infections (SARI)
Authors: Debadatta Dhar Chanda  , Chhandasree Biswas  , Supriya Upadhyay  
Published: February 2023

BACKGROUND
Influenza is viral fever with the main symptoms of the respiratory tract like cough, fever, breathlessness, nasal discharge, sore throat & myalgia. Pandemic 2009 H1N1 influenza A was the virus that presented a significant public health threat on a global scale. This prospective study was undertaken to analyse the prevalence of the influenza virus in patients with a severe acute respiratory infection (SARI) and also to determine the demographic characteristics and seasonal variations.
METHODS
This was a hospital-based prospective study done in the Department of Microbiology, Silchar Medical College & Hospital, Silchar for 1 year from June 2021 to May 2022. Respiratory specimens were tested for Influenza virus by one step real-time reverse transcription polymerase chain reaction (RT-PCR).
RESULTS
In real-time PCR, the influenza virus was detected in 6 out of 85 SARI patients (7%). Of 6 total positives, 4(67%) were influenza A and 2(33%) were influenza B. Among 4 influenza A positive cases, 3(75%) were influenza A (H1N1) pdm09 and 1(25%) was seasonal influenza A (H3N2). The highest percentage of positivity (50%) was detected in the age group of 15-29 years. The most common symptoms among the positive influenza cases were fever (100%), cough (88%), and breathlessness (56%). Other associated symptoms were sore throat (63%), nasal discharge (75%), and myalgia (75%).
CONCLUSIONS
This study clearly shows that influenza is an important cause of severe acute respiratory infection. It also suggests the need for continuous effective surveillance of influenza viruses to detect cases and control outbreaks. Early intervention and proper management of influenza virus cases are required to curb the disease burden.
Large Frontal Defect Reconstructed with a Suprafascial Anterolateral Thigh Flap and Brow Suspension with a Fascia Lata Frontalis Sling
Authors: Surya Rao Rao Venkata Mahipathy  , Manoj Ananthappan  , Narayanamurthy Sundaramurthy  , Anand Prasath Jayachandiran  , Alagar Raja Durairaj  
Published: February 2023

A 60-year-old gentleman presented with a single, dark scaly lesion over the forehead for the past 8 years. It started as a small plaque spontaneously, insidious in onset and gradually progressed to the present size. There was no history of trauma, pain or bleeding from the lesion. No history of similar complaints in the family. On examination, there was a large hyperpigmented plaque measuring 15 x 10 cm with well-defined margins and rolled-out edges with ulceration 2 x 0.5cm at the centre. (Fig. 1) Edge wedge biopsy from the lesion revealed a proliferation of basaloid cells which showed features consistent with basal cell carcinoma - atypical mitosis and peripheral palisading. After obtaining anaesthetic fitness, we proceeded with wide local excision with 1cm margin done by the surgical oncology team. (Fig. 2) We then followed by reconstruction of the frontalis sling using fascia lata and covered the defect with a free suprafascial ALT flap with superficial temporal as the recipient artery as an end-to-end anastomosis. (Fig. 3, 4) The donor site was resurfaced with SSG. The histopathology report was consistent with basal cell carcinoma without any perineural involvement. The early postoperative period showed the flap supple and soft with no oedema. (Fig. 5) On regular follow-up, the flap was well settled with good cosmesis. (Fig. 6)
Detection of moisture content in logs using multi-parameter GPR signal analysis and neural network models
Authors: Guo Jiaxing , Wang Peng , Qin Ruixia , Zhao Liming , Tang Xu , Zeng Jianyong , Xu Huadong 
Published: February 2023

Abstract
To address the low accuracy of non-destructive detection of moisture content (MC) of logs (especially in small diameters) by ground penetrating radar (GPR) signals, the MC of 10–15 cm diameter spruce, Manchurian ash, and white birch logs were predicted using the time-frequency parameters of the GPR signals and a back-propagation neural network (BPNN) model. B-scan signals were obtained using tree radar on the barks of discs selected from fresh green logs. Then, 31 time-frequency parameters from the B-scan signals were optimised using the least absolute shrinkage and selection operator (Lasso) and principal component analysis (PCA). Finally, the log MCs of the single and hybrid models was predicted using the BPNN. The accuracy of the least absolute shrinkage and selection operator and back-propagation neural network (Lasso-BP) were higher than those of the principal component analysis and back-propagation neural network (PCA-BP), and the BPNN. The individual species and hybrid models both have good predictive capability; when the log MC is below 20%, the maximum residual errors are relatively small, almost within 6% and 10%, respectively. These models significantly improve the accuracy of non-destructive detection of log MC and are beneficial for efficient wood processing.
On the quality checking of persistent scatterer interferometry data by spatial-temporal modelling
Authors: Omidalizarandi Mohammad , Mohammadivojdan Bahareh , Alkhatib Hamza , Paffenholz Jens-André , Neumann Ingo 
Published: February 2023

Abstract
Today, rapid growth in infrastructure development and urbanisation process increases the attention for accurate deformation monitoring on a relatively large-scale. Furthermore, such deformation monitoring is of great importance in the assessment and management of natural hazard processes like landslides, earthquakes, and floods. In this study, the Persistent Scatterer Interferometry (PSI) technique is applied using open-source Synthetic Aperture Radar (SAR) data from the satellite Sentinel-1. It allows point-wise deformation monitoring based on time series analysis of specific points. It also enables performing spatio-temporal area-based deformation monitoring. Currently, these data do not have a sophisticated quality assurance process to judge the significance of deformations. To obtain different quality classes of the Persistent Scatterer (PS) data points, the first step is to classify them into buildings and ground types using LoD2 building models. Next, time series analysis of the PS points is performed to model systematic and random errors. It allows estimation of the offset and the deformation rate for each point. Finally, spatio-temporal modelling of neighbourhood relations of the PS points is carried out using local geometric patches which are approximated with a mathematical model, such as, e.g., multilevel B-Splines. Subsequently, the quality of SAR data from temporal and spatial neighbourhood relations is checked. Having an appropriate spatio-temporal quality model of the PS data, a deformation analysis is performed for areas of interest in the city of Hamburg. In the end, the results of the deformation analysis are compared with the BodenBewegungsdienst Deutschland (Ground Motion Service Germany) provided by the Federal Institute for Geosciences and Natural Resources (BGR), Germany.
The crystal structure of 4-(pyren-1-yl)butyl-4-nitrobenzoate, C27H21NO4
Authors: Barrientos Claudio , Squella Juan Arturo , Moris Silvana 
Published: February 2023

AbstractC27H21NO4, triclinic,P1‾$P\overline{1}$(no. 2),a = 7.3476(2) Å,b = 7.4894(2) Å,c = 20.5137(5) Å,α= 89.33000(10)°,β= 79.7070(10)°,γ= 67.5220(10)°,V = 1024.31(5) Å3,Z = 2,Rgt(F) = 0.0536, wRref(F2) = 0.1792, T = 296.15 K.
Analysis of thrombosis risk of commissural misaligned transcatheter aortic valve prostheses using particle image velocimetry
Authors: Borowski Finja , Kaule Sebastian , Oldenburg Jan , Schmitz Klaus-Peter , Öner Alper , Stiehm Michael 
Published: February 2023

Abstract
Due to excellent clinical results, transcatheter aortic valve replacement (TAVR) has evolved to a treatment option for patients with low surgical risk, resulting in an increasing demand for durable heart valve prostheses. Durability of TAVR could be limited by leaflet thrombosis. Thrombus formation in the aortic root is mainly affected by the hemodynamic situation, which is dependent on the positioning of the implant. We investigated the flow field in the aortic root after TAVR implantation by means of particle image velocimetry. To quantify the influence of the implant-position with respect to an alignment or misalignment of the leaflet commissures on the thrombogenic potential, we used a transport equation for residence time (RT) to consider washout behavior. Furthermore, we introduced a shear effect criterion (SIE) to address platelet activation as a measure for a potential thrombus formation. Misaligned implantation of a TAVR resulted in a reversed direction of rotation of the occurring recirculation area. This led to fluid flow with comparable areas of increased relative blood RT (RTaligned: 97.6%, RTmisaligned: 88.0%) and a smaller area of low shear load for the misaligned TAVR (SIEaligned: 57.7%, SIEmisaligned: 3.70%) into the sinus region, indicating a higher potential for thrombus formation.
Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease
Authors: Bhatnagar Akanksha , Krick Keegan , Karisetty Bhanu Chandra , Armour Ellen M. , Heller Elizabeth A. , Elefant Felice 
Published: February 2023

The severity of Alzheimer's disease (AD) progression involves a complex interplay of genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT)-mediated neuroepigenetic mechanisms. While disruption of Tip60 HAT action in neural gene control is implicated in AD, alternative mechanisms underlying Tip60 function remain unexplored. Here, we report a novel RNA binding function for Tip60 in addition to its HAT function. We show that Tip60 preferentially interacts with pre-mRNAs emanating from its chromatin neural gene targets in theDrosophilabrain and this RNA binding function is conserved in human hippocampus and disrupted inDrosophilabrains that model AD pathology and in AD patient hippocampus of either sex. Since RNA splicing occurs co-transcriptionally and alternative splicing (AS) defects are implicated in AD, we investigated whether Tip60-RNA targeting modulates splicing decisions and whether this function is altered in AD. Replicate multivariate analysis of transcript splicing (rMATS) analysis of RNA-Seq datasets from wild-type and AD fly brains revealed a multitude of mammalian-like AS defects. Strikingly, over half of these altered RNAs are identified as bona-fide Tip60-RNA targets that are enriched for in the AD-gene curated database, with some of these AS alterations prevented against by increasing Tip60 in the fly brain. Further, human orthologs of several Tip60-modulated splicing genes inDrosophilaare well characterized aberrantly spliced genes in human AD brains, implicating disruption of Tip60's splicing function in AD pathogenesis. Our results support a novel RNA interaction and splicing regulatory function for Tip60 that may underly AS impairments that hallmark AD etiology.SIGNIFICANCE STATEMENTAlzheimer's disease (AD) has recently emerged as a hotbed for RNA alternative splicing (AS) defects that alter protein function in the brain yet causes remain unclear. Although recent findings suggest convergence of epigenetics with co-transcriptional AS, whether epigenetic dysregulation in AD pathology underlies AS defects remains unknown. Here, we identify a novel RNA interaction and splicing regulatory function for Tip60 histone acetyltransferase (HAT) that is disrupted inDrosophilabrains modeling AD pathology and in human AD hippocampus. Importantly, mammalian orthologs of several Tip60-modulated splicing genes inDrosophilaare well characterized aberrantly spliced genes in human AD brain. We propose that Tip60-mediated AS modulation is a conserved critical posttranscriptional step that may underlie AS defects now characterized as hallmarks of AD.
A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling
Authors: Zhu Lingxin , Tang Yi , Li Xiao‐Yan , Kerk Samuel A , Lyssiotis Costas A , Feng Wenqing , Sun Xiaoyue , Hespe Geoffrey E , Wang Zijun , Stemmler Marc P , Brabletz Simone , Brabletz Thomas , Keller Evan T , Ma Jun , Cho Jung‐Sun , Yang Jingwen , Weiss Stephen J 
Published: February 2023

AbstractOsteoclasts are bone‐resorbing polykaryons responsible for skeletal remodeling during health and disease. Coincident with their differentiation from myeloid precursors, osteoclasts undergo extensive transcriptional and metabolic reprogramming in order to acquire the cellular machinery necessary to demineralize bone and digest its interwoven extracellular matrix. While attempting to identify new regulatory molecules critical to bone resorption, we discovered that murine and human osteoclast differentiation is accompanied by the expression of Zeb1, a zinc‐finger transcriptional repressor whose role in normal development is most frequently linked to the control of epithelial‐mesenchymal programs. However, following targeting, we find that Zeb1 serves as an unexpected regulator of osteoclast energy metabolism. In vivo, Zeb1‐null osteoclasts assume a hyperactivated state, markedly decreasing bone density due to excessive resorptive activity. Mechanistically, Zeb1 acts in a rheostat‐like fashion to modulate murine and human osteoclast activity by transcriptionally repressing an ATP‐buffering enzyme, mitochondrial creatine kinase 1 (MtCK1), thereby controlling the phosphocreatine energy shuttle and mitochondrial respiration. Together, these studies identify a novel Zeb1/MtCK1 axis that exerts metabolic control over bone resorption in vitro and in vivo.