bluuebunny/crossref_metadata_2025_split huggingface dataset:
Keuangan generasi z: Tingkat literasi dalam rangka peningkatan inklusi keuangan digital
Authors: Putri Vindaniar Yuristamanda , Halim Ruth Melisa , Fahira Tira Nur , Janice Stephanie Nuriani 
Published: June 2023

Tingkat literasi keuangan pada generasi Z masih pada tingkat less literate, sementara itu tingkat konsumsi generasi Z umumnya digunakan untuk memenuhi gaya hidup. Berdasarkan hal tersebut tujuan dari pengabdian masyarakat ini adalah untuk meningkatkan literasi dan inklusi siswa/i Sekolah Menengah Atas (SMA) XI yang tergolong pada generasi Z. Pengabdian masyarakat ini menggunakan metode Community-Based Participant Research (CBPR) dengan Teknik sosialisasi dan workshop yang mencakup pengetahuan dasar keuangan, manajemen keuangan, kredit dan hutang, tabungan dan investasi, risiko, asuransi, dan pengelolaan keuangan menggunakan media expense tracker. Untuk mengetahui efektivitas dari pengabdian masyarakat ini, analisis pretest posttest (pretest posttest analysis) menggunakan uji beda dilakukan. Dengan menggunakan uji hipotesis Wilcoxon Signed Rank Test, terdapat perbedaan yang signifikan pada tingkat literasi keuangan digital pada saat sebelum dilakukannya pengabdian masyarakat dengan setelah dilakukannya pengabdian masyarakat. Tingkat literasi keuangan digital siswa/i mengalami peningkatan yang diketahui dari nilai mean rank POSTTEST > PRETEST (25,31 > 17,00). Sehingga disimpulkan bahwa peningkatan literasi dan inklusi keuangan digital pada generasi Z di SMA Muhammadiyah 2, Depok harus tetap dilakukan sejak dini agar generasi Z tidak terjebak pada permasalahan-permasalahan keuangan di masa yang akan datang. Tindak lanjut dari program ini adalah seluruh peserta dibekali dengan expense tracker sheet yang dimonitor oleh tiap wali kelas, agar siswa/i terbiasa memonitor pengeluaran mereka dan memiliki kesadaran keuangan yang baik.
Upaya kegiatan kuliah kerja nyata integratif mendorong motivasi petani ikan dalam peningkatan produksi ikan air tawar
Authors: Grandiosa Roffi , Rosidah Rosidah , Putra Pringgo Kusuma Dwi Noor Yadi 
Published: June 2023

Pembudidaya ikan di Desa Cintaratu yang tergabung dalam Kelompok Kaliwungu Rahayu di Pangandaran dikenal dengan budidaya ikan Tilapia, Mas dan Nilem. Kelompok budidaya ini disertifikasi oleh Kementerian Kelautan dan Perikanan Indonesia, namun pengembangan budidaya ikan tergantung pada pengetahuan pembudidaya karena produksi di daerah setempat masih belum efektif. KKN atau yang dikenal dengan Kuliah Kerja Nyata Universitas Padjadjaran telah membawa hasil positif dimana dosen bersama mahasiswa dan petani belajar bersama mengenai topik inovasi pakan dalam budidaya seperti aplikasi herbal dan probiotik melalui metoda Participatory Action Research Method. Hasil pengamatan menunjukkan bahwa 100% petani ikan responden merasakan kegiatan pengabdian ilmiah memberikan manfaat terhadap peningkatan produksi dan peningkatan ilmu pengetahuan. Sekarang para pembudidaya menyadari faktor-faktor penting dari inovasi kualitas pakan ini yang berdampak nyata langsung pada turunnya rasio konversi pakan, meningkatnya pertumbuhan, meningkatnya pertumbuhan dan kelangsungan hidup ikan, membaiknya kesehatan dan produksi ikan. Pengetahuan praktik terbaik untuk mengimplementasikan kemajuan teknologi dalam budidaya sangat penting untuk memberdayakan budidaya ikan di daerah pedesaan.
Optimalisasi peran kader posyandu dalam peningkatan kesehatan ibu dan anak
Authors: Indahwati Lilik , Dewi Mustika , Fatmawati Fatmawati , Gayatri Mergy , Dewi Triyana Sinta , Sari Mita Herlina , Savitri Meiliana Eka 
Published: June 2023

Masalah kesehatan ibu hamil dan anak merupakan masalah yang harus dipantau secara berkelanjutan terutama di daerah pasca bencana seperti pasca erupsi Semeru. Kader adalah bagian dari masyarakat yang memiliki akses langsung kepada masyarakat di wilayahnya. Kader kesehatan sangat membantu dalam peningkatan kesehatan ibu dan anak. Dengan demikian diperlukan update pengetahuan untuk menunjang peran tersebut. Tujuan kegiatan adalah meningkatkan pengetahuan kader melalui pelatihan tentang kesehatan ibu dan anak. Kegiatan ini dilaksanakan di Desa kawasan rawan bencana Gunung Semeru, Kecamatan Pronojiwo, Kabupaten Lumajang. Pelatihan diikuti oleh 24 kader. Metode kegiatan yaitu Participatory Action Research (PAR). Hasil kegiatan menunjukkan adanya peningkatan pengetahuan kader tentang kesehatan ibu dan anak, yang awalnya baik menjadi sangat baik. Diharapkan kegiatan selanjutnya dapat mengaplikasikan metode tersebut untuk meningkatkan keterampilan kader terkait kesehatan ibu dan anak.
Advances in molecular characterization of pediatric acute megakaryoblastic leukemia not associated with Down syndrome; impact on therapy development
Authors: Li Jixia , Kalev‐Zylinska Maggie L. 
Published: June 2023

Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML) in which leukemic blasts have megakaryocytic features. AMKL makes up 4%–15% of newly diagnosed pediatric AML, typically affecting young children (less than 2 years old). AMKL associated with Down syndrome (DS) shows GATA1 mutations and has a favorable prognosis. In contrast, AMKL in children without DS is often associated with recurrent and mutually exclusive chimeric fusion genes and has an unfavorable prognosis. This review mainly summarizes the unique features of pediatric non-DS AMKL and highlights the development of novel therapies for high-risk patients. Due to the rarity of pediatric AMKL, large-scale multi-center studies are needed to progress molecular characterization of this disease. Better disease models are also required to test leukemogenic mechanisms and emerging therapies.
The impact of geriatric nutritional risk index on one-year outcomes in hospitalized elderly patients with heart failure
Authors: Miura Masakazu , Okuda Shinichi , Murata Kazuhiro , Ohno Yutaka , Katou Satoshi , Nakao Fumiaki , Ueyama Takeshi , Yamamoto Takeshi , Ikeda Yasuhiro 
Published: June 2023

BackgroundStrategies that accurately predict outcomes in elderly heart failure (HF) patients have not been sufficiently established. In previous reports, nutritional status, ability to perform activities of daily living (ADL), and lower limb muscle strength are known prognostic factors associated with cardiac rehabilitation (CR). In the present study, we investigated which CR factors can accurately predict one-year outcomes in elderly patients with HF among the above factors.MethodsHospitalized patients with HF over 65 years of age from January 2016 to January 2022 were retrospectively enrolled in the Yamaguchi Prefectural Grand Medical (YPGM) Center. They were consequently recruited to this single-center retrospective cohort study. Nutritional status, ADL, and lower limb muscle strength were assessed by geriatric nutritional risk index (GNRI), Barthel index (BI), and short physical performance battery (SPPB) at discharge, respectively. One year after discharge, the primary and secondary outcomes were evaluated by all-cause death or HF readmission and major adverse cardiac and cerebrovascular events (MACCE), respectively.ResultsOverall, 1,078 HF patients were admitted to YPGM Center. Of those, 839 (median age 84.0, 52% female) met the study criteria. During the follow-up of 228.0 days, 72 patients reached all-cause death (8%), 215 experienced HF readmission (23%), and 267 reached MACCE (30%: 25 HF death, six cardiac death, and 13 strokes). A multivariate Cox proportional hazard regression analysis revealed that the GNRI predicted the primary outcome (Hazard ratio [HR]: 0.957; 95% confidence interval [CI]: 0.934–0.980; p &lt; 0.001) and the secondary outcome (HR: 0.963; 95%CI: 0.940–0.986; p = 0.002). Furthermore, a multiple logistic regression model using the GNRI most accurately predicted the primary and secondary outcomes compared to those with the SPPB or BI models.ConclusionA nutrition status model using GNRI provided a better predictive value than ADL ability or lower limb muscle strength. It should be recognized that HF patients with a low GNRI at discharge may have a poor prognosis at one year.
Experiences of health professional students’ participation in the GEMx regional elective exchange program in Africa
Authors: Nawagi Faith , Iacone Anna , Seeling Justin , Yuan Shiyao , Mukherjee Snigdha 
Published: June 2023

BackgroundGiven the significant gap in International Electives (IEs) opportunities for African health professions students, ECFMG|FAIMER through its Global Educational Exchange in Medicine and other health professions (GEMx) program launched a pilot African regional elective exchange program in 2016. During IEs, students have a choice of discipline they would like to learn, and the location, often at a host institution in a different country. This study provides an overview of health professional students’ experiences through participation in the pilot GEMx regional elective exchange program in Africa.MethodsThis was a quasi-experimental, single-group post-test-only study using the survey method. Data were collected online using a self-administered survey through SurveyMonkey. Students (N= 107) received emails with a link to the survey as they completed the electives. The survey was open for a month for each student and weekly reminders were sent.ResultsThe survey obtained a 100% response rate. All postgraduate and undergraduate students from various professional training programs (n= 107) reported gaining knowledge that was applicable back home. Over 43.4% (n= 46) reported having formed professional networks that are valuable for career progression. More than half 59.8% (n= 64) gained clinical skills and learned various procedures while 26.2% (n= 28) recognized the need for increased reliance on history taking for disease diagnosis. More than a third, 34.6% (n= 37) appreciated the different cultures and the effect of cultural beliefs on health outcomes.Discussion and conclusionsThe GEMx regional elective exchange program in Africa provided a useful platform that enabled health professional students at undergraduate and postgraduate levels in their respective disciplines to gain enhanced perspectives on health issues, acquire clinical knowledge and skills applicable to their home country, strengthen personal and professional development, and develop positive attitude change in various health care delivery approaches.
A frameshift variant in the SIRPB1 gene confers susceptibility to Crohn’s disease in a Chinese population
Authors: Tang Jian , Wan Xingyang , Zhang JunXiao , Diao Na , Zhang Caibin , Gao Xiang , Ren Donglin 
Published: June 2023

Background: Crohn’s disease (CD), a chronic gastrointestinal inflammatory disease, is increasing in China. With a focus on Han Chinese families with CD, the aim of this study was to find genetic variations that increase CD susceptibility by genome sequencing, genetic association, expression, and functional research.Materials and methods: We performed family-based genome sequencing (WGS) analysis on 24 patients with CD from 12 families and then filtered shared potential causal variants by incorporating association results from meta-analyses of CD GWAS and immunology genes and in silico variant effect prediction algorithms. Replication analyses were performed in an independent cohort including 381 patients with CD and 381 control subjects.Results: There were 92 genetic variants significantly associated with CD in Chinese individuals. Among them, 61 candidate loci were validated in replication analyses. As a result, patients carrying a rare frameshift variant (c.1143_1144insG; p. Leu381_Leu382fs) in gene SIRPB1 had significantly higher risk to develop CD (p = 0.03, OR 4.59, 95% CI 0.98–21.36, 81.82% vs. 49.53%). The frameshift variation induced tyrosine phosphorylation of Syk, Akt, and Jak2, elevated the expression of SIRPB1 at the mRNA and protein levels, activated DAP12, and controlled the activation of NF-κB in macrophages. Additionally, it promoted the synthesis of the pro-inflammatory cytokines IL-1, TNF-, and IL-6.Conclusion: Our results suggest that the rare gain-of-function frameshift variant in SIRPB1 is associated in Han Chinese patients with CD. The functional mechanism of SIRPB1 and its downstream inflammatory pathways was preliminarily explored in CD.
Correlation analysis of vaginal microecology and different types of human papillomavirus infection: a study conducted at a hospital in northwest China
Authors: Feng Fang , Hou Yue-min , Zhang Yan , Wang Lu-yuan , Li Pei-pei , Guo Ying , An Rui-fang 
Published: June 2023

BackgroundVaginal microecology has a definite influence on human papillomavirus (HPV) infection and clearance, but the specific correlation is still controversial. This research aimed to investigate the differences in the vaginal microenvironment of different types of HPV infection and also provide data supporting clinical diagnosis and treatment.MethodsAccording to strict inclusion and exclusion criteria, the case data of 2,358 female patients who underwent vaginal microecology and HPV-DNA tests at the same time in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Xi'an Jiaotong University from May 2021 to March 2022 were retrospectively analyzed. The population was divided into two groups: an HPV-positive group and an HPV-negative group. HPV-positive patients were further classified into HPV16/18-positive group and HPV other subtypes positive group. The vaginal microecology of HPV-infected patients was analyzed using the chi-square test, Fisher's exact test, and logistic regression.ResultsAmong the 2,358 female patients, the HPV infection rate was 20.27% (478/2,358), of which the HPV16/18 infection rate was 25.73% (123/478), and the HPV other subtypes infection rate was 74.27% (355/478). The difference in HPV infection rates between the age groups was statistically significant (P &lt; 0.01). The prevalence of mixed vaginitis was 14.37% (339/2,358), with bacterial vaginosis (BV) paired with aerobic vaginitis (AV) accounting for the majority (66.37%). The difference in HPV infection rates among mixed vaginitis was not statistically significant (P &gt; 0.05). The prevalence of single vaginitis was 24.22% (571/2,358), with the most frequent being vulvovaginal Candidiasis (VVC; 47.29%, 270/571), and there was a significant difference in HPV infection rates among single vaginitis (P &lt; 0.001). Patients with BV had a higher risk of being positive for HPV16/18 (OR: 1.815, 95% CI: 1.050–3.139) and other subtypes (OR: 1.830, 95% CI: 1.254–2.669). Patients with Trichomoniasis were at higher odds of other HPV subtype infections (OR: 1.857, 95% CI: 1.004–3.437). On the contrary, patients with VVC had lower odds of becoming infected with other HPV subtypes (OR: 0.562, 95% CI: 0.380–0.831).ConclusionThere were disparities in HPV infection among different age groups; therefore, we should pay attention to the prevention and treatment of susceptible individuals. BV and Trichomoniasis are linked to HPV infection; hence, restoring the balance of vaginal microecology could assist in the prevention of HPV infection. As a protective factor for other HPV subtype infections, VVC may provide new insights into the development of immunotherapeutic therapies.
SSTM-IS: simplified STM method based on instance selection for real-time EEG emotion recognition
Authors: Ran Shuang , Zhong Wei , Duan Danting , Ye Long , Zhang Qin 
Published: June 2023

IntroductionEEG signals can non-invasively monitor the brain activities and have been widely used in brain-computer interfaces (BCI). One of the research areas is to recognize emotions objectively through EEG. In fact, the emotion of people changes over time, however, most of the existing affective BCIs process data and recognize emotions offline, and thus cannot be applied to real-time emotion recognition.MethodsIn order to solve this problem, we introduce the instance selection strategy into transfer learning and propose a simplified style transfer mapping algorithm. In the proposed method, the informative instances are firstly selected from the source domain data, and then the update strategy of hyperparameters is also simplified for style transfer mapping, making the model training more quickly and accurately for a new subject.ResultsTo verify the effectiveness of our algorithm, we carry out the experiments on SEED, SEED-IV and the offline dataset collected by ourselves, and achieve the recognition accuracies up to 86.78%, 82.55% and 77.68% in computing time of 7s, 4s and 10s, respectively. Furthermore, we also develop a real-time emotion recognition system which integrates the modules of EEG signal acquisition, data processing, emotion recognition and result visualization.DiscussionBoth the results of offline and online experiments show that the proposed algorithm can accurately recognize emotions in a short time, meeting the needs of real-time emotion recognition applications.
Multivariate prediction of long COVID headache in adolescents using gray matter structural MRI features
Authors: Kim Minhoe , Sim Sunkyung , Yang Jaeseok , Kim Minchul 
Published: June 2023

ObjectiveHeadache is among the most frequent symptoms after coronavirus disease 2019 (COVID-19), so-called long COVID syndrome. Although distinct brain changes have been reported in patients with long COVID, such reported brain changes have not been used for predictions and interpretations in a multivariate manner. In this study, we applied machine learning to assess whether individual adolescents with long COVID can be accurately distinguished from those with primary headaches.MethodsTwenty-three adolescents with long COVID headaches with the persistence of headache for at least 3 months and 23 age- and sex-matched adolescents with primary headaches (migraine, new daily persistent headache, and tension-type headache) were enrolled. Multivoxel pattern analysis (MVPA) was applied for disorder-specific predictions of headache etiology based on individual brain structural MRI. In addition, connectome-based predictive modeling (CPM) was also performed using a structural covariance network.ResultsMVPA correctly classified long COVID patients from primary headache patients, with an area under the curve of 0.73 (accuracy = 63.4%; permutation p = 0.001). The discriminating GM patterns exhibited lower classification weights for long COVID in the orbitofrontal and medial temporal lobes. The CPM using the structural covariance network achieved an area under the curve of 0.81 (accuracy = 69.5%; permutation p = 0.005). The edges that classified long COVID patients from primary headache were mainly comprising thalamic connections.ConclusionThe results suggest the potential value of structural MRI-based features for classifying long COVID headaches from primary headaches. The identified features suggest that the distinct gray matter changes in the orbitofrontal and medial temporal lobes occurring after COVID, as well as altered thalamic connectivity, are predictive of headache etiology.
Translation and concurrent validity, sensitivity and specificity of Chinese version of Short Orientation Memory Concentration Test in people with a first cerebral infarction
Authors: Zhao Jiang-Li , Chen Pei-Ming , Ng Shamay S. M. , Mao Yu-Rong , Huang Dong-Feng 
Published: June 2023

PurposeThis study aimed to translate the English version of the Short Orientation-Memory-Concentration (SOMC) test into a Chinese version, denoted the C-SOMC test, and to investigate the concurrent validity, sensitivity, and specificity of the C-SOMC test against a longer and widely used screening instrument in people with a first cerebral infarction.MethodsAn expert group translated the SOMC test into Chinese using a forward–backward procedure. Eighty-six participants (67 men and 19 women, mean age = 59.31 ± 11.57 years) with a first cerebral infarction were enrolled in this study. The validity of the C-SOMC test was determined using the Chinese version of Mini Mental State Examination (C-MMSE) as the comparator. Concurrent validity was determined using Spearman’s rank correlation coefficients. Univariate linear regression was used to analyze items’ abilities to predict the total score on the C-SOMC test and the C-MMSE score. The area under the receiver operating characteristic curve (AUC) was used to demonstrate the sensitivity and specificity of the C-SOMC test at various cut-off values distinguishing cognitive impairment from normal cognition.ResultsThe total score for the C-SOMC test and the score for item 1 on this test exhibited moderate-to-good correlations with the C-MMSE score, with respective ρ-values of 0.636 and 0.565 (P &lt; 0.001). The scores for each of items 2, 4, 5, 6, and 7 yielded fair correlations with C-MMSE score, with ρ-value from 0.272 to 0.495 (P &lt; 0.05). The total score on the C-SOMC test and the item score were good predictors (adjusted R2 = 0.049 to 0.615) of the C-MMSE score, and six items were good predictors (adjusted R2 = 0.134 to 0.795) of the total score. The AUC was 0.92 for the C-SOMC test. A cut-off of 17/18 on the C-SOMC test gave optimal performance: correct classification of 75% of participants, with 75% sensitivity and 87.9% specificity.ConclusionThe C-SOMC test demonstrated good concurrent validity, sensitivity and specificity in a sample of people with a first cerebral infarction, demonstrating that it could be used to screen for cognitive impairment in stroke patients.
Adjuvant therapy with Huatan Sanjie Granules improves the prognosis of patients with primary liver cancer: a cohort study and the investigation of its mechanism of action based on network pharmacology
Authors: Yuan Juhua , Abdurahman Abdusami , Cui Ning , Hao Tengteng , Zou Jianhua , Liu Liren , Wu Yu 
Published: June 2023

Objective: Nowadays, primary liver carcinoma (PLC) is one of the major contributors to the global cancer burden, and China has the highest morbidity and mortality rates in the world. As a well-known Chinese herbal medicine (CHM) prescription, Huatan Sanjie Granules (HSG) has been used clinically for many years to treat PLC with remarkable efficacy, but the underlying mechanism of action remains unclear.Methods: A clinical cohort study was conducted to observe the overall survival of PLC patients with vs. without oral administration of HSG. Meanwhile, the BATMAN-TCM database was used to retrieve the potential active ingredients in the six herbs of HSG and their corresponding drug targets. PLC–related targets were then screened through the Gene Expression Omnibus (GEO) database. The protein–protein interaction (PPI) network of targets of HSG against PLC was constructed using Cytoscape software. The cell function assays were further carried out for verification.Results: The results of the cohort study showed that the median survival time of PLC patients exposed to HSG was 269 days, which was 23 days longer than that of the control group (HR, 0.62; 95% CI, 0.38–0.99; p = 0.047). In particular, the median survival time of Barcelona Clinic Liver Cancer stage C patients was 411 days in the exposure group, which was 137 days longer than that in the control group (HR, 0.59; 95% CI, 0.35–0.96; p = 0.036). Meanwhile, the enrichment analysis result for the obtained PPI network consisting of 362 potential core therapeutic targets suggest that HSG may inhibit the growth of liver cancer (LC) cells by blocking the PI3K-Akt/MAPK signaling pathways. Furthermore, the above prediction results were verified by a series of in vitro assays. Specifically, we found that the expressions TP53 and YWHA2, the targets of the hepatitis B virus signaling pathway, were significantly affected by HSG.Conclusion: HSG shows promising therapeutic efficacy in the adjuvant treatment of PLC.