bluuebunny/crossref_metadata_2025_split huggingface dataset:
MICAL1 stability by PlexinA1 promotes gastric cancer cell migration
Authors: ye fengwen , Xia Tianxiang , Wang Yueyuan , Min Pengxiang , Wang Qianwen , Zhao Weizhen , Yang Yixing , Zhang Yujie , Du Jun 
Published: September 2023

Abstract
Background
For metastasis to proceed, tumor cells must become mobile by modulating their cytoskeleton. MICAL1 is known as an actin cytoskeleton regulator, but the mechanisms by which it drives cancer cell migration are still unclear.
Methods
Immunohistochemistry assays and western blotting were used to detect the expression levels of MICAL1 in gastric cancer tissues and cells. Immunoprecipitation and immunofluorescence staining were used to detect the interactions of proteins. Wound-healing and transwell assays were performed to demonstrate the migratory function of MICAL1 in gastric cancer cells. In addition, qPCR, bioinformatics analysis, pulldown assay, ROS detection as well as western blotting were conducted to verify the mechanism of MICAL1 in gastric cancer cell migration.
Results
Analysis of gastric cancer tissues revealed that MICAL1 are elevated in gastric cancer tissues compared with non-tumor tissues and that its high expression is predictive of poor survival. PlexinA1 and MICAL1 were directly interact with each other. Specific inhibition of PlexinA1 accelerated MICAL1 ubiquitination and proteasome-based degradation. Furthermore, PlexinA1 positively regulates MICAL1 expression via Rac1 activation and following ROS production. Functional studies confirmed that PlexinA1 and MICAL1 facilitated gastric cancer cell migration via promoting vimentin expression.
Conclusions
These results indicate that PlexinA1 is a key regulator of MICAL1 stability via a Rac1/ROS dependent manner, and MICAL1 stability may be involved in promoting vimentin expression and gastric cancer cell migration.
Inflammation and altered metabolism impede efficacy of Functional Electrical Stimulation in critically ill patients
Authors: TSO Jameson , MK Caldow , Stephens F , Denehy L , Lynch GS , Koopman R , Krajcova A , Urban T , Berney Sue , Duska Frantisek , Puthucheary Zudin 
Published: September 2023

Abstract

BackgroundCritically ill patients suffer from acute muscle wasting, which is associated with significant physical functional impairment. We describe data from nested muscle biopsy studies from two trials of functional electrical stimulation (FES) that did not shown improvements in physical function.MethodsPrimary cohort:single-centre randomized controlled trial. Additional healthy volunteer data from patients undergoing elective hip arthroplasty.Validation cohort:Four-centre randomized controlled trial.Intervention: FES cycling for 60-90min/day.Analyses:Skeletal muscle mRNA expression of 223 genes underwent hierarchal clustering for targeted analysis and validation.ResultsPositively enriched pathways between healthy volunteers and ICU participants were “stress response” “response to stimuli” and “protein metabolism”, in keeping with published data. Positively enriched pathways between admission and day 7 ICU participants were “FOXO-mediated transcription” (admission = 0.48±0.94, day 7 = -0.47±1.04 mean log2fold change;P=0.042), “Fatty acid metabolism” (admission = 0.50±0.67, day 7 = 0.07±1.65 mean log2fold change;P=0.042) and “Interleukin-1 processing” (admission = 0.88±0.50, day 7 = 0.97±0.76 mean log2fold change;P=0.054). Muscle mRNA expression of UCP3 (P=0.030) and DGKD (P=0.040) decreased in both cohorts with no between group differences. Changes in IL18 were not observed in the validation cohort (P=0.268). Targeted analyses related to intramuscular mitochondrial substrate oxidation, fatty acid oxidation and intramuscular inflammation showed PPARg-C1α; (P<0.001), SLC25A20 (P=0.017) and UCP-3 (P<0.001) decreased between admission and day 7 in both arms. LPIN-1 (P<0.001) and SPT1 (P=0.044) decreased between admission and day 7. IL-18 (P=0.011) and TNFRSF12A (P=0.009) increased in both arms between admission and day 7. IL-1β (P=0.007), its receptor IL-1R1 (P=0.005) and IL-6R (P=0.001) decreased in both arms between admission and day 7. No between group differences were seen in any of these (all p>0.05).Conclusions:Intramuscular inflammation and altered substrate utilisation are persistent in skeletal muscle during first week of critical illness and are not improved by the application of Functional Electrical Stimulation-assisted exercise. Future trials of exercise to prevent muscle wasting and physical impairment are unlikely to be successful unless these processes are addressed by other means than exercise alone.
Mechanism of Effect of Non-Reactive Polyhedral Oligomeric Silsesquioxane Nanostructures on HTPB-Based Polyurethane Network Formation: A Rheokinetic Analysis
Authors: Moein Abolfazl , Kebritchi Abbas 
Published: September 2023

Abstract

This study explored the influence of non-reactive POSS nanostructures (Octa isobutyl silsesquioxane (OIBS) and Octa phenyl silsesquioxane (OPS)) on polyurethane (PU) from Hydroxyl-terminated polybutadiene (HTPB) resin and various curing agents (Toluene diisocyanate (TDI), Hexamethylene diisocyanate (HDI), Isophorone diisocyanate (IPDI), and Dimeryl-diisocyanate (DDI)). Contrary to previous expectations, POSS nanostructures enhanced the initial viscosity of HTPB resin. The Chemo-rheological method and Arrhenius and Eyring equations were employed to determine the reaction kinetics of PU synthesis. It was found that POSS nanostructures modulated the reaction kinetics between isocyanate and diol depending on the curing agent and POSS type. For instance, POSS accelerated the reaction in IPDI and TDI systems but slowed it down in the DDI system. In the HDI system, the POSS effect varied with its type and concentration, which were analyzed in detail. Besides the type of POSS, the nanostructure concentration also affected the PU synthesis's kinetics. Different concentrations of OIBS and OPS in each system were compared, and the possible reasons for the observed patterns were discussed. These results were explained by considering the interactions between POSS nanostructures and PU components. A plausible mechanism for the role of non-reactive POSS in PU synthesis kinetics was proposed.
Phytoremediation by ornamental sunflower and its effects on the properties of drainage water
Authors: Mohammadian Elham , anesh Sasan Faramarzm , Garmdareh Seyyed Ebrahim Hashemi , Varavipoor Maryam 
Published: September 2023

Abstract
due to legal restrictions on burning and burying sewage sludge in land and oceans, experts recommend using the sludge as fertilizer in agriculture to avoid the environmental problems associated with its disposal. Using sewage sludge in agriculture has limitations due to the presence of heavy metals, which can cause soil pollution and potentially harm animals and humans through the food chain. Furthermore, the use of sewage sludge can also lead to salinity and pollution of underground water by increasing the levels of nitrates and heavy metals in the soil water. The aim of this study was to explore the potential of using ornamental sunflowers for phytoremediation and to examine how this process affects the properties of drainage water. This research was conducted in the research greenhouse of Aburaihan campus of Tehran University. The sewage sludge was related to the sewage treatment plant in the south of Tehran and was prepared anaerobically and dewatered. Sewage sludge containing 0, 10 and 20 percent by weight of soil was done in three replications in the form of a completely randomized block design. Ornamental sunflower plant (Helianthus annuus) was used in this research. During the growth period, the water drains from the first watering after applying the treatments and the water drain from the last watering of the pots before harvesting the flowers were collected. The test results showed that the use of sewage sludge causes a significant increase in the concentration of Pb, Ni and Cd in the Ornamental sunflower roots and drainage water. But the concentration of these elements is lower than the standard limit and it shows that sunflower is able to purify these metals. Also, the amount of nitrogen and potassium in the water was increased.
An integrated approach to remove endocrine-disrupting chemicals bisphenol and its analogues from the aqueous environment: a review
Authors: A. V. Monica , K. Anbalagan , I. Becky Miriyam 
Published: September 2023

Abstract

Bisphenol A (BPA) is a well-known endocrine-disrupting chemical (EDC) used as a plastic enhancer in producing polycarbonate resins to manufacture hard plastics. Due to strict limitations on the manufacturing and utilization of BPA, several bisphenol substitutes, bisphenol F (BPF), bisphenol S (BPS), and bisphenol AF (BPAF), have been developed to replace it in various applications. Because of their widespread use in food containers, infant bottles, and reusable water bottles, bisphenols (BPs) have been identified in different environmental circumstances, including drinking water, seawater, industrial effluent, and endocrine systems such as human blood, urine, and breast milk. However, locating and analyzing them in different conditions has proven to be challenging. Therefore, there is a need to reduce the prevalence of BPs in the environment. The significance of advanced treatment options for treating and eliminating BPA and its alternatives from water bodies are reviewed. Also, the research gaps and future scopes are discussed in this review article. According to the literature survey, adsorption and photocatalytic degradation provide synergistic benefits for environmental challenges because of their substantial adsorption Q5 capacity, high oxidation capability, and low cost compared to alternative individual treatment options.
Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System
Authors: Esposito Matteo , Palermo Sara , Nahi Ylenia Camassa , Tamietto Marco , Celeghin Alessia 
Published: September 2023

Abstract:
The ability of the brain to recognize and orient attention to relevant stimuli appearing in the
visual field is highlighted by a tuning process, which involves modulating the early visual system by
both cortical and subcortical brain areas. Selective attention is coordinated not only by the output of
stimulus-based saliency maps but is also influenced by top-down cognitive factors, such as internal
states, goals, or previous experiences. The basal ganglia system plays a key role in implicitly modulating
the underlying mechanisms of selective attention, favouring the formation and maintenance of implicit
sensory-motor memories that are capable of automatically modifying the output of priority maps
in sensory-motor structures of the midbrain, such as the superior colliculus. The article presents an
overview of the recent literature outlining the crucial contribution of several subcortical structures to
the processing of different sources of salient stimuli. In detail, we will focus on how the mesencephalic-
basal ganglia closed loops contribute to implicitly addressing and modulating selective attention
to prioritized stimuli. We conclude by discussing implicit behavioural responses observed in clinical
populations in which awareness is compromised at some level. Implicit (emergent) awareness in
clinical conditions that can be accompanied by manifest anosognosic symptomatology (i.e., hemiplegia)
or involving abnormal conscious processing of visual information (i.e., unilateral spatial neglect
and blindsight) represents interesting neurocognitive “test cases” for inferences about mesencephalicbasal
ganglia closed-loops involvement in the formation of implicit sensory-motor memories.
Identifying Cannabidiol (CBD) Research Priorities Relevant to
Child and Adolescent Psychiatry
Authors: Hulvershorn Leslie , Weinstein Sally , Bixler Kristina , Murray Olivia K. , Smoker Michael , Hammond Christopher 
Published: September 2023

Abstract:
Cannabidiol (CBD), a plant-derived cannabinoid compound found in
cannabis, has been readily available in the United States since the legalization of
hemp products in 2018. With all 50 states legalizing some form of CBD, many
products have appeared in the marketplace. The American public generally
considers CBD a safe and effective way to manage pain, mental health conditions,
and other health issues in children and adults, even though CBD has only been
approved for the treatment of specific types of pediatric seizures. This report
describes early findings from preclinical CBD studies, select clinical trials, and
naturalistic observational studies of CBD users and identifies knowledge gaps in
this emerging field, especially those relating to the developmental effects of CBD.
The main goal of this report is to identify priorities for future CBD research,
particularly those that will benefit the field of child and adolescent psychiatry.
In vitro Study on Antioxidant and Antiglycation Activities, and Molecular
Docking of Moroccan Medicinal Plants for Diabetes
Authors: Rhizlan Abdnim , Amine Elbouzidi , Ouassou Hayat , Elrherabi Amal , Berraaouan Ali , Legssyer Abdelkhaleq , Ziyyat Abderrahim , Mekhfi Hassane , Bnouham Mohamed 
Published: September 2023

Background:
Moroccan medicinal plants with historical usage to treat diabetes have
been analyzed to explore their potential anti-glycation and antioxidant activities through in vitro experiments.
These investigations have been complemented by molecular docking.

Methods:
The present study has examined the in vitro antioxidant and antiglycation properties of
six aqueous extracts from six medicinal plants (Ammodaucus leucotrichus, Thymelaea hirsuta, Arbutus
unedo, Urtica dioica, Ptychotis verticillata, and Caralluma europaea), and two seeds oils
from Argania spinosa and Opuntia dillenii. The antioxidant activity was determined by using the
DPPH radical scavenging activity test and β-carotene/linoleic acid bleaching assay. In addition, the
antiglycation activity was detected by using the hemoglobin protein model.

Results:
All studied plant extracts have shown potent antioxidant and antiglycation activity. Furthermore,
to confirm the in silico antiglycation activity of the selected medicinal plants, molecular
docking techniques were used assuming that binding energy decreases as compound affinity increases;
the best molecules responsible for the remarkable antiglycation activity have also been
highlighted.

Conclusion:
Antidiabetic herbal medicines are responsible for the inhibition of oxidative activity
and glycation. The molecular docking analysis showed catechin, kaempferol-O-acetylhexoside, luteolin,
luteolin-7-O-glucoside, quercetin, and zeaxanthin, to have a high affinity to AGEs receptor
and a potent inhibitory activity.
Investigation of Corrosion Protection Through CNTs/ CNFs Modified
Cement Mortars
Authors: Panagiotakopoulou Christina , Papandreopoulos Panagiotis , Batis George 
Published: September 2023

background:
the performance of nano modified cement based materials is substantial in
terms of their mechanical durability and other similar properties that are of great importance in the
functional life of cement structures. The motivation of this study is to formulate conclusions concerning
the anti-corrosive impact of Carbon nanotubes (CNTs) and Carbon nanofibers (CNFs) on the
properties of mortar specimens and respectively on their service life.

methods:
The nano additives performance, was investigated through Scanning methods, such as X-ray
diffraction (XRD), and Scanning Electron Microscopy (SEM) which analyze the microstructure of
mortar specimens with 0.1 % wt addition of CNTs and 0.1 % wt addition of CNFs in their synthesis.
In addition, other techniques such as total chloride content and gravimetric mass loss measurements,
provide a consolidated assessment of the impact of the nano modified cement materials. In particular,
(SEM) and (XRD) microstructure analysis results showed that nanoadditives are found as agglomerates
in the cement paste, whereas their hydrophobic nature blocks the diffusion of corrosive factors into
the cement paste. Additionally, the total chloride content in mortar specimens with CNFs is approximately
50% less than the relevant percentage of the specimens without additives, which is in compliance
with the relevant percentages of porosity values. Furthermore, from the elemental analysis of all
specimens, it is found that the samples that are corroded are the specimens without nano additives.

results:
The addition of nanomodified materials affects the porosity and the microstructure of the
mortar specimens.

conclusion:
The addition of 0,1 % of CNTs or CNFs positively affects against corrosion impact while
exposure in extremely corrosive conditions.
Usefulness of Unstimulated and Stimulated Whole Saliva, Accuracy of Minor Labial Salivary Gland Biopsy in the Diagnosis of Primary Sjögren's Disease: A Croatian Single-Center, Cross-Sectional Study
Authors: Baric Ivona , Tadin Antonija , Glavina Ana 
Published: September 2023

The aim of this cross-sectional study was to determine the accuracy of minor labial salivary gland (MLSG) biopsy in the diagnosis of primary Sjögren' s disease (pSD); to study the correlation between the focus score (FS) and anti-SSA/Ro, anti-SSB/La, anti-SSA and -SSB antibodies, unstimulated whole saliva (UWS) and stimulated whole saliva (SWS); to determine the role of UWS and SWS in the clinical evaluation of pSD patients and patients with sicca symptoms.
Methods. A total of 37 subjects were enrolled in the study and divided into two groups: the test group consisted of 15 patients diagnosed with pSD; the control group consisted of 22 patients who had sicca symptoms but did not meet the 2016 American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) diagnostic criteria. Clinical and laboratory tests, including saliva collection, MLSG biopsy, autoantibody titers, were performed in all patients.
Results. The median of the FS was 1.00 [IQR=1.00-1.50] in the test group, whereas in the control group, it was 0.00 [IQR=0.00-0.00] (p< 0.001). The sensitivity, specificity, and accuracy of MLSG biopsy were 86.7%, 100.0%, and 94.6%, respectively. The results showed a correlation between the FS and antinuclear antibodies (ANA) (p=0.002). In addition, Pearson’s correlation showed a weak negative correlation between UWS (r=-0.058, p=0.73) and SWS (r=-0.022, p=0.90) and the FS. In the test group, 73.3% of patients had abnormal UWS values, while 86.7% had abnormal SWS values; among them, values of 0.00 ml/min for UWS and SWS were found in 60.0% and 26.7% of patients, respectively.
Conclusions. Although MLSG biopsy has great diagnostic value and accuracy in diagnosing pSD, it is not always definitive. Our study found a statistically significant association between the FS and ANA, and the greater utility of SWS in diagnosing pSS.
A Case of Long COVID-19 Myocarditis with Asymptomatic Manifestation in a Young Male
Authors: Savchenko Oleksandr , Tyravska Yuliya , Moshkovska Yuliya , Pliskevych Dina , Altunina Nataliia , Lizogub Viktor 
Published: September 2023

Background. Myocarditis is one of the most dangerous complications of both the acute phase of COVID-19 and long COVID-19, with a rather heterogeneous clinical presentation that ranges from asymptomatic to life-threatening. The diverse clinical presentation with a high risk of further complications, on the one hand, and a good prognosis in case of appropriate treatment, on the other hand, demand great attention from doctors.
Case Report. We report a case of a 27-year-old male presented to a cardiologist with complaints of dyspnea, chest pain, palpitation occurred eight months after a mild COVID-19 episode. The diagnostic search commenced with a detailed questioning and physical examination with further laboratory testing and instrumental procedures, including resting electrocardiography, resting two-dimensional speckle-tracking echocardiography, and stress echocardiography. Gadolinium-enhanced cardiac magnetic resonance was the final step in diagnosis establishment. Half-a-year follow-up period of the patient with asymptomatic manifestation of COVID-19 myocarditis demonstrated the normalization of the condition after prescribed pathogenetic treatment.
Conclusions. This case report raises awareness of the need for prolonged follow-up of patients after an episode of COVID-19 and proposes a comprehensive approach to a possible differential diagnostic search for precise diagnosis and treatment in a young male with rationale based on the relevant literature.
World Englishes Representation in English Textbooks of Indonesian Elementary Schools
Authors: Annisa Rifka Nida , Gusdian Rosalin Ismayoeng 
Published: September 2023

This study aimed at investigating the representation of World Englishes (WE) in English textbooks used in elementary schools in Indonesia. Two English books for a sixth-graders were used as the data sources. This study used qualitative approach and document analysis as the method to gather the data. The collected data were then analyzed based on Braj Kachru's theory of World Englishes comprising inner, outer, and expanding circles. The analyzed data were eventually validated by the experts in the field of applied linguistics. The findings show that the inner circle and expanding circle representations are found in these two books. The representation of both circles was reflected from pictures and reading texts. Meanwhile, the outer circle did not acquire ample depiction in both books. In conclusion, the effort of introducing WE to elementary school students has been presented in the text books that were dominated by expanding circles based on the research in this study case.
El juez, el historiador y el inquisidor. El testimonio histórico como prueba y como diálogo.
Authors: Urteneche Gonzalo 
Published: September 2023

Este trabajo tiene por objetivo realizar una distinción entre dos modelos de justicia que sirven de presupuesto para la historiografía: el modelo inquisitorial o infraccional y el adversarial u oral. Estos presupuestos se corresponderían con un determinado tratamiento de los testimonios orales en la historiografía a los que identifico como “inferencial” y “dialógico”. Tomando como caso paradigmático de análisis de la relación entre historia y justicia al libro de Carlo Ginzburg El juez y el historiador. Consideraciones a propósito del proceso de Sofri, propondré que la analogía entre historiografía y justicia inquisitorial no puede sostenerse en el contexto de aparición de la Historia del Tiempo Presente. Así, recuperando las críticas de Alberto Binder a la noción infraccional y su alegato en favor de la oralidad, analizaré el caso presente en Algo parecido a la felicidad. Una historia de la lucha de la clase trabajadora durante la década del setenta (1973-1978) de Federico Lorenz desde la óptica del testimonio entendido como “institución natural dialógica” propuesta por Paul Ricoeur.
Palabras clave: Testimonio histórico, Testimonio judicial, Evidencia, Diálogo