bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of folate receptor‐positive circulating tumor cells in the diagnosis of lung cancer and its correlation with clinical characteristics
Authors: Xu Yunjian , Li Qianjun , Lin Zhijian , Lin Yongping 
Published: March 2023

AbstractObjectiveThe aim of this research is to investigate the feasibility of folate receptor‐positive circulating tumor cells (FR+CTCs) as a biomarker for the diagnosis of malignant pulmonary nodules and the correlation between clinicopathological factors and FR+CTC levels.MethodsPatients initially diagnosed with one or more pulmonary nodules from a computed tomography scan were prospectively included. Three milliliters of peripheral blood was collected from each participant for FR+CTC analysis prior to surgery. Clinical and pathological parameters and FR+CTC levels were compared between patients with lung cancer and benign diseases.ResultsSix hundred fifty‐three patients had lung cancer and the other 124 had benign lung diseases based on pathological examinations of the resected specimens. The median FR+CTC value of the lung cancer group was 12.0 (95% CI 9.6–16.2) FU/3 mL and that of the benign group was 7.2 (95% CI 5.78–11.2) FU/3 mL. The difference was statistically significant (P < 0.0001). In a receiver operating characteristic analysis to distinguish the two groups, the area under curve of FR+CTC was 0.7457 (95% CI 0.6893–0.8021; P < 0.0001) using a cutoff of 8.65 FU/3 mL. The sensitivity was 86.37%, and the specificity was 74.19%. Combined with conventional serum tumor biomarkers, the area under curve was 0.922 (0.499–0.963). The sensitivity was 92.20%, and the specificity was 83.05%. FR+CTC levels were related to tumor staging (P4 < 0.001), the degree of tumor invasion both in single (P = 0.011) and multiple lesions (P = 0.022), pathological subtypes (P = 0.013), and maximum tumor diameter (P = 0.014).ConclusionsFR+CTC is an effective and reliable biomarker for the diagnosis of lung cancer. Further, FR+CTC level is correlated with tumor staging, degree of invasion, pathological subtypes, and tumor size.
The Free Sign in morphea and other sclerosing disorders: A clue to the presence of early sclerosis?
Authors: Ortega‐Springall Maria Fernanda , Yang Sarah , Mitra Anupam , Fung Maxwell A. 
Published: March 2023

AbstractBackgroundThe Floating Sign is a histopathologic clue to the diagnosis of autoimmune sclerosing skin disorders such as morphea and interstitial granulomatous dermatitis (IGD). On the other hand, the “free‐floating” sign has been associated with neoplasms, for example, dermatofibroma and interstitial mycosis fungoides. Herein, we report the Free Sign in sclerosing skin disorders.MethodsIn a case‐control study, we applied detailed histopathologic definitions of Floating Sign and Free Sign to assess their presence in morphea, IGD, and other sclerosing disorders.ResultsFree Sign was present in most cases of morphea (46/55, 84%) and IGD (7/13, 54%) but not necrobiosis lipoidica (NL) (6/14, 42.8%) or sclerodermoid graft versus host disease (SGVHD) (2/7, 28.5%). The sensitivity and specificity of Free Sign for morphea versus other disorders was 84% and 56%, respectively. Floating Sign was not identified in most cases: NL (3/14, 21.4%), SGVHD (1/7, 14.2%), morphea (5/55, 9%), IGD (1/13, 7.7%). The diagnostic sensitivity of Floating Sign in morphea was 9%.ConclusionsThe Free Sign was present in most cases of morphea in our series and may represent a clue to the presence of evolving sclerosis. Free Sign may be seen in other sclerosing disorders. Technical artifact is a potential cause of a false‐positive Free Sign.
Women's alcohol consumption in the early parenting period and influences of socio‐demographic and domestic circumstances: A scoping review and narrative synthesis
Authors: Vicario Serena , Buykx Penny , Peacock Marian , Hardie Iain , De Freitas Loren , Bissell Paul , Meier Petra Sylvia 
Published: March 2023

AbstractIssuesNumerous studies have explored alcohol consumption in pregnancy, but less is known about women's drinking in the early parenting period (EPP, 0–5 years after childbirth). We synthesise research related to three questions: (i) How are women's drinking patterns and trajectories associated with socio‐demographic and domestic circumstances?; (ii) What theoretical approaches are used to explain changes in consumption?; (iii) What meanings have been given to mothers' drinking?ApproachThree databases (Ovid‐MEDLINE, Ovid‐PsycINFO and CINAHL) were systematically searched. Citation tracking was conducted in Web of Science Citation Index and Google Scholar. Eligible papers explored mothers' alcohol consumption during the EPP, focusing on general population rather than clinical samples. Studies were critically appraised and their characteristics, methods and key findings extracted. Thematic narrative synthesis of findings was conducted.Key FindingsFourteen quantitative and six qualitative studies were identified. The (sub)samples ranged from n = 77,137 to n = 21 women. Mothers' consumption levels were associated with older age, being White and employed, not being in a partnered relationship, higher education and income. Three theoretical approaches were employed to explain these consumption differences: social role, role deprivation, social practice theories. By drinking alcohol, mothers expressed numerous aspects of their identity (e.g., autonomous women and responsible mothers).Implications and ConclusionAlcohol‐related interventions and policies should consider demographic and cultural transformations of motherhood (e.g., delayed motherhood, changes in family structures). Mothers' drinking should be contextualised carefully in relation to socio‐economic circumstances and gender inequalities in unpaid labour. The focus on peer‐reviewed academic papers in English language may limit the evidence.
Selected genodermatoses – Status quo and future prospects
Authors: Frank Jorge , Has Cristina , Betz Regina C. 
Published: March 2023

SummaryGenodermatoses are monogenetic disorders, which may manifest with symptoms either exclusively on the skin or also involve other organs in the context of an associated syndrome. Over the past 30 years, numerous hereditary hair, tumor, blistering, and keratinization diseases have been characterized both clinically and genetically. This has resulted in the continuous development of disease‐specific classifications as well as diagnostic algorithms and examination techniques, and has also led to new pathogenesis‐based therapeutic approaches. While the deciphering of the underlying genetic defects of these diseases is already well advanced, there is still much room for the development of new translationally motivated treatment strategies.
Biodiversity, biogeography, and connectivity of polychaetes in the world's largest marine minerals exploration frontier
Authors: Stewart Eva C. D. , Bribiesca‐Contreras Guadalupe , Taboada Sergi , Wiklund Helena , Ravara Ascensão , Pape Ellen , De Smet Bart , Neal Lenka , Cunha Marina R. , Jones Daniel O. B. , Smith Craig R. , Glover Adrian G. , Dahlgren Thomas G. 
Published: March 2023

AbstractAimThe abyssal Clarion‐Clipperton Zone (CCZ), Pacific Ocean, is an area of commercial importance owing to the growing interest in mining high‐grade polymetallic nodules at the seafloor for battery metals. Research into the spatial patterns of faunal diversity, composition, and population connectivity is needed to better understand the ecological impacts of potential resource extraction. Here, a DNA taxonomy approach is used to investigate regional‐scale patterns of taxonomic and phylogenetic alpha and beta diversity, and genetic connectivity, of the dominant macrofaunal group (annelids) across a 6 million km2 region of the abyssal seafloor.LocationThe abyssal seafloor (3932–5055 m depth) of the Clarion‐Clipperton Zone, equatorial Pacific Ocean.MethodsWe used a combination of new and published barcode data to study 1866 polychaete specimens using molecular species delimitation. Both phylogenetic and taxonomic alpha and beta diversity metrics were used to analyse spatial patterns of biodiversity. Connectivity analyses were based on haplotype distributions for a subset of the studied taxa.ResultsDNA taxonomy identified 291–314 polychaete species from the COI and 16S datasets respectively. Taxonomic and phylogenetic beta diversity between sites were relatively high and mostly explained by lineage turnover. Over half of pairwise comparisons were more phylogenetically distinct than expected based on their taxonomic diversity. Connectivity analyses in abundant, broadly distributed taxa suggest an absence of genetic structuring driven by geographical location.Main ConclusionsSpecies diversity in abyssal Pacific polychaetes is high relative to other deep‐sea regions. Results suggest that environmental filtering, where the environment selects against certain species, may play a significant role in regulating spatial patterns of biodiversity in the CCZ. A core group of widespread species have diverse haplotypes but are well connected over broad distances. Our data suggest that the high environmental and faunal heterogeneity of the CCZ should be considered in future policy decisions.
The effects of India's bilateral investment treaties termination on foreign direct investment inflows
Authors: Kotyrlo Elena , Kalachyhin Hryhorii M. 
Published: March 2023

AbstractIndia initiated the unilateral mass termination of bilateral investment treaties (BIT termination) in 2016. We consider it a natural experiment to clarify the issue of whether BITs attract foreign direct investment (FDI) to a developing country. We evaluate the effect of BIT termination on the FDI inflows using the double and triple difference approaches (DD and DDD) and the synthetic control (SCM) methods. Our study finds that BIT termination led to a significant decrease in FDI inflows from the country with which India terminated the agreement. Thus, the study confirms that BIT is an essential mechanism for attracting FDI.
Circadian rhythm and aneurysmal subarachnoid hemorrhage: Is there an alarm clock for the rupture timing?
Authors: Gümüs Meltem , Said Maryam , Chihi Mehdi , Dinger Thiemo F. , Rodemerk Jan , Frank Benedikt , Oppong Marvin Darkwah , Dammann Philipp , Wrede Karsten H. , Forsting Michael , Sure Ulrich , Jabbarli Ramazan 
Published: March 2023

AbstractBackground and purposeData on the temporal distribution of the bleeding time of intracranial aneurysms are limited to a few small studies. With this study, the aim was to analyze time patterns of the occurrence of aneurysmal subarachnoid hemorrhage (SAH), particularly focusing on the impact of patients' socio‐demographic and clinical characteristics on the ictus timing.MethodsThe study is based on an institutional SAH cohort with 782 consecutive cases treated between January 2003 and June 2016. Data were collected on the ictus time, patients' socio‐demographic and clinical characteristics, as well as the initial severity and outcome. Univariate and multivariate analyses were performed on the bleeding timeline.ResultsThere were two peaks in the circadian rhythm of SAH, one in the morning (7–9 a.m.) and the other in the evening (7–9 p.m.). The strongest alterations in the bleeding time patterns were observed for weekdays, patients' age, sex and ethnicity. Individuals with chronic alcohol and painkiller consumption showed a higher bleeding peak between 1 and 3 p.m. Finally, the bleeding time showed no impact on the severity, clinically relevant complications and the outcome of SAH patients.ConclusionsThis study is one of the very few detailed analyses of the impact of specific socio‐demographic, ethnic, behavioral and clinical characteristics on the rupture timing of aneurysms. Our results point to the possible relevance of the circadian rhythm for the rupture event, and therefore might be useful in the elaboration of preventive measures against aneurysm rupture.
Efficacy of remote ischemic conditioning does not differ between men and women: A secondary analysis of the RICAMIS study
Authors: Qu Hui‐Ling , Sun Xiao‐Yu , Cui Yu , Zhang Yi‐Na , Chen Hui‐Sheng 
Published: March 2023

AbstractBackground and PurposeThe present study aimed to determine sex difference in clinical outcomes after Remote Ischemic Conditioning for Acute Moderate Ischemic Stroke (RICAMIS).MethodsIn this secondary analysis of the RICAMIS study, eligible patients aged 18 years or older with acute moderate ischemic stroke who received remote ischemic conditioning (RIC) within 48 h of stroke onset were divided into two groups: men and women. The primary endpoint was an excellent functional outcome, defined as a modified Rankin Scale score of 0–1 at 90 days. Binary logistic regression analyses and generalized linear models were used.ResultsOf 1707 eligible patients, 34% (579) were women. Women had a higher burden of hypertension and diabetes, and less alcohol and smoking consumption than men. The mean systolic blood pressure and blood glucose level at randomization were higher in women than in men. Compared with the control group, RIC was associated with an increased rate of primary endpoint in men (unadjusted odds ratio [OR] = 1.277; 95% confidence interval [CI] 0.933–1.644; p = 0.057) and women (unadjusted OR = 1.454; 95% CI 1.040–2.032; p = 0.028). Furthermore, a higher absolute risk difference in primary endpoint between control and RIC groups was found in women (9.2%) than in men (5.7%), but there was no significant interaction effect between sex and intervention on primary outcome (p interaction = 0.545).ConclusionCompared with men, women may have a higher probability of excellent functional outcomes at 90 days in the RIC group than in the control group; however, no interaction effect between sex and intervention was found.
Tick size and price efficiency: Further evidence from the Tick Size Pilot Program
Authors: Chung Kee H. , Chuwonganant Chairat 
Published: March 2023

AbstractThis paper examines whether larger tick sizes improve or hinder price efficiency for small‐capitalization stocks using data from implementing and terminating the Tick Size Pilot Program (TSPP). We show that the TSPP led to increases in various liquidity measures, and its termination restored them to their pre‐TSPP levels. We also find evidence that the TSPP led to trader migration from the pilot to control stocks. The TSPP implementation (termination) is associated with decreases (increases) in price efficiency, indicating that price efficiency decreases with tick sizes. Liquidity and informed trading are two channels through which the TSPP changes price efficiency.
GERMAN COLONIALISM IN EAST AFRICA AND ITS AFTERMATH IN ABDULRAZAK GURNAH'S NOVELS PARADISE AND AFTERLIVES AND IN CONTEMPORARY GERMAN LITERATURE
Authors: Göttsche Dirk 
Published: March 2023

ABSTRACTBritish author and literary scholar Abdulrazak Gurnah, born in Zanzibar in 1948 and awarded the Nobel Prize for Literature in 2021, makes significant contributions to the memory and critique of German colonialism in East Africa and its aftermath both in Tanzania and in Germany. This study examines Gurnah's novels Paradise (1994) and Afterlives (2020) for their representation of German imperial rule and its impact on Swahili society and culture and its place in the Indian Ocean universe, World War I in East Africa, the fate of askari soldiers in Weimar and Nazi Germany, and the memory and postmemory of German colonialism through to the 1960s. Gurnah's literary modelling of African experiences and memories of German colonialism is discussed in Anglo‐German comparative perspective with reference to postcolonial memory discourses in contemporary German literature, including Afro‐German life‐writing.
Commanding men, governing masculinities: Military institutional abuse and organizational reform in the Australian armed forces
Authors: Wadham Ben , Connor James 
Published: March 2023

AbstractSince its inception, the Australian armed forces, like all five eye military nations, have been challenged by the phenomenon of violence within the institution. Militaries are institutions of and for violence. The imperative of violence cultivates all service personnel through their initial training and then ongoing roles. This article assesses 4 decades of significant Australian military inquiries around the question of internal institutional violence, including bullying, sexual assault, sexual harassment, hazing, and bastardization. We define this as “military institutional abuse,” which represents a new term for describing this phenomenon that allows for a deeper understanding of institutional gendered and martial culture. The aim is to provide the first overview of military institutional abuse within the Australian military. We argue that military institutional abuse is not an anomaly but endemic to the military institution. In the last decade, there has been a significant activity around gender reforms, changing the alcohol culture and the tribal forms of masculinity associated with it. The question of how the military has responded to this phenomenon illuminates better avenues of cultural reform and responds to the problematic question, “to what extent can this authoritarian institution liberalize”?
Functional decline in persons with haemophilia and factors associated with deterioration
Authors: Blokzijl Johan , Pisters Martijn F. , Veenhof Cindy , Schutgens Roger E. G. , Timmer Merel A. 
Published: March 2023

AbstractIntroductionThe World Haemophilia Federation advises regular musculoskeletal assessment covering all International Classification of Functioning and Health (ICF) domains, including limitations in activities and participation in persons with haemophilia (PWH). This enables clinicians to detect changes early and enable adjustments in personalized healthcare when needed. However, data on the course of physical functioning and occurrence of decline is lacking. The aim of this study is to describe changes in perceived limitations in activities of PWH and to identify factors associated with a change.MethodsData were collected from medical health records of regular check‐up visits of adults with moderate and severe haemophilia in two time periods. Perceived limitations in activities was measured with the Haemophilia Activities List (HAL). Association between variables (e.g., age, body mass index, bleeding rate and synovitis) and change in perceived limitations was assessed using a generalized linear model.ResultsA total of 104 PWH were included. At T0, the median HAL sum score was 79.5 (IQR 62.1–93.6) and at T1 the median HAL sum score was 74.2 (IQR 57.5–88.3). A functional decline was found in 35.6% of PWH, 55.8% remained stable and 8.7% improved. Among other variables, a BMI > 30 kg/m2 appeared to be an important factor that negatively influenced the change in perceived functioning in adult PWH. With the included factors we could only explain a small part of this decline (R2adj: .12).ConclusionThe majority of PWH remained stable in their perceived functional ability over mid‐long term (median 3.5 years). However, about a third showed a clinical relevant decline in their functional ability.
Untersuchungen zum Phenylpropanstoffwechsel des Pollens
Authors: Wiermann R. 
Published: March 2023

ZusammenfassungUnter den Farbstoffen, die die Pigmentgarnitur des Pollens bestimmen, nehmen die flavonoiden Verbindungen eine hervorragende Stellung ein. Die phytochemischen Untersuchungen am Pollen von 132 dicotylen und monocotylen Arten aus 40 Familien lassen erkennen, daß die Pigmentgarnitur sehr einfache Züge trägt und in erster Linie durch die ubiquitär verbreiteten Verbindungen Quercetin, Kämpferol und Isorhamnetin bestimmt ist. Auf das häufige Vorkommen von Naringenin als Nebenkomponente des Flavonoidmusters wird aufmerksam gemacht. Die Pigmentausstattung des Gymnospermenpollens scheint durch häufigeres Auftreten von Flavonen und Flavanonolen bereichert zu sein.Es wird darauf hingewiesen, daß auch in Sporen von Farnen und Moosen flavonoide Verbindungen vorkommen können.Für die Bestimmung einiger Salix‐ und Populus‐Arten möchte ich Herrn F. Mang, Hamburg, vielmals danken. Herzlich gedankt sei auch Fräulein V. Scholand für ihre Hilfe bei der technischen Durchführung dieser Untersuchungen.
Pollenkorntypen und Sektionegliederung der Gattung Myosotis
Authors: Grau Jürke , Leins Peter 
Published: March 2023

ZusammenfassungBei den hier untersuchten Myosotis‐Arten können sieben Pollenkorntypen unterschieden werden, die sich auf zwei Hauptgruppen verteilen lassen. Die eine Gruppe ist durch sehr kleine taillierte Pollenkörner gekennzeichnet (arvensis‐ und verna‐Typ). Die andere Gruppe besitzt deutlich größere Pollenkörner, die eine gewisse Formenmannigfaltigkeit aufweisen (discolor‐, australis‐, uniflora‐, exarrhena‐ und angustata‐Typ). Pollenkörner vom arvensis‐Typ besitzen die eurasiatischen Sippen (mit Ausnahme der westeuropäischen discolor‐Gruppe) sowie die südafrikanischen Arten. Der nur wenig verschiedene verna‐Typ gehört der nordamerikanischen M. verna an. Die australis‐, uniflora‐, exarrhena‐ und angustata‐Typen betreffen die Pollenkörner der Sippen aus Neuseeland, Australien und Patagonien. Pollenkörner vom discolor‐Typ hat neben der westeuropäischen discolor‐Gruppe noch die afrikanische M. abyssinica. Eine Gliederung nach den Pollenkorntypen zeigt mit der de Candolleschen Sektionsgliederung nur wenig Übereinstimmung. Da der Wert der zur Sektionseinteilung herangezogenen Blüten‐ und Klausenmerkmale recht zweifelhaft erscheint, wird nach den palynologischen Befunden eine sinnvollere Lösung erwogen: eine Zusammenfassung der eurasiatischen (mit Ausnahme der discolor‐Gruppe), nordamerikanischen und südafrikanischen Sippen einerseits sowie der restlichen südhemisphärischen Sippen andererseits. Eine Entscheidung über die discolor‐Gruppe und die augenscheinlich verwandte M. abyssinica soll zunächst noch nicht getroffen werden.
Zur Kenntnis der Soziologie und Ökologie der Schwermetallvegetation Großbritanniens1
Authors: Ernst Wilfried 
Published: March 2023

ZusammenfassungAuf den schwermetallreichen Böden Großbritanniens wurden soziologische und ökologische Untersuchungen durchgeführt. Die Schwermetallpflanzengesellschaften sind durch Minuartia verna und Thlaspi alpestre gekennzeichnet und können in die Klasse der europäischen Schwermetallpflanzengesellschaften, Violetea calaminariae, und innerhalb dieser in den westeuropäischen Verband Thlaspeion calaminariae gestellt werden.In ökologischen Untersuchungen konnte nachgewiesen werden, das Thlaspi alpestre und Minuartia verna erhebliche Zinkmengen in den Preßsäften speichern. Eine mengenmäßige Berechnung ergibt einen Anteil des im Preßsaft gespeicherten Zinks am Gesamtzinkgehalt von 46 bis 88% für Thlaspi alpestre und von 16 bis 68% für Minuartia verna. Der Anteil des Zinks am osmotischen Wert beträgt bei Thlaspi alpestre 2,1 bis 6,8% und bei Minuartia verna von 0,3 bis 1,8%. Dabei weisen die Preßsäfte von Pflanzen mit einem hohen Zinkgehalt hohe Sulfat‐, hingegen nur niedrige Phosphatkonzentrationen auf.
Bodenatmung und Streuproduktion verschiedener tropischer Pflanzengemeinschaften
Authors: Medina Ernesto 
Published: March 2023

ZusammenfassungDie „Bodenatmung” in einigen tropischen Pflanzengemeinschaften Venezuelas wird gemessen und in Beziehung zu der Stoffproduktion an Trockenmasse gebracht.
Thyrea radiata, eine Lempholemma‐Art mit Hormocystangien
Authors: Henssen Aino 
Published: March 2023

ZusammenfassungVon der Flechte Thyrea radiata konnten erstmals Apothecien untersucht werden. Nach Bau und Entwicklung der Apothecien sowie auf Grund des Vorkommens von Hormocystangien gehört die Flechte zur Gattung Lempholemma. Die neue Kombination Lempholemma radiatum wurde gemacht. Der Bau der Hormocystangien bei verschiedenen Lempholemma‐Arten wird kurz geschildert. L. radiatum wurde erstmals im kontinentalen Nordamerika, in Alberta und Alaska, gesammelt.