bluuebunny/crossref_metadata_2025_split huggingface dataset:
INDONESIAN HEALTH IN CRISIS: ASSOCIATION BETWEEN COGNITIVE FUNCTION AND DEPRESSION
Authors: Arya Pangestu Rikky , Hidayati Iswana Zahraa , Martini Santi , Suryadi Rahman Firman , Mohamed Gomaa Nasr Nayla , Rahman Muhammad Aziz 
Published: June 2023

Background: Depression differs from common mood swings and short-lived emotions. It has been extensively reported that cognitive impairment is associated with depression. Depression affects all aspects of life and interferes with productivity. Purpose: This study examined the association between cognitive function and depression in an Indonesian working age group. Methods: We used data from longitudinal socioeconomic and health surveys based on the fifth wave of the Indonesian Family Life Survey (IFLS) from October 2014 to April 2015. Household members aged 15-64 were included in the analysis. Depression was assessed using the Short Center for Epidemiological Research Depression Scale (CESD). Cognitive function was measured using the Cognitive Status Telephone Interview (TICS). Simple linear regression analysis was performed to examine the association between cognitive function and depression. Results: A total of 10,628 households were included. Most respondents had good cognitive function (61.84%) and no depression (82.19%). A simple linear regression analysis showed that household members with good cognitive functioning had a significantly lower risk of developing depression compared to household members with cognitive decline, he was significantly 1.28 lower. Conclusion: This study found a significant association between cognitive function and depression in the productive-age group. Further research exploring variables related to depression other than cognitive function is recommended. Health care providers should provide education, counselling, and training sessions related to healthy lifestyles and positive mindsets to prevent depression.
Analisis Strategi Komunikasi Krisis Klinik Kesehatan Gigi di Masa Pandemi COVID-19
Authors: Puspitasari Salsabilla Arum , Afifi Subhan 
Published: June 2023

The dental health clinic is one of the institutions experiencing a crisis during the COVID-19 Pandemic. People who are worried about contracting COVID-19 refrain from visiting various health service institutions, including the Dental Health Clinic, which is considered a source of transmission because it is related to the mouth and teeth. This has an impact on decreasing the number of patients and affecting the existence of the business. This study aims to analyze the crisis communication strategy of a Dental Health Clinic in Banjarmasin during the COVID-19 Pandemic. The method used in this research is the case study method as part of descriptive qualitative research. Data collection techniques used in-depth interviews, observation and document analysis. The results showed that although the Dental Health Clinic, which was the object of the study, did not have a special Public Relations, it had carried out the role and function of Public Relations in crisis communication. The crisis communication strategy is implemented in a planned and systematic manner in 3 crisis phases: Pre-crisis, crisis and Post-crisis. Clinic Management Accommodative Strategy with Rectification as a crisis communication strategy tactic during the COVID-19 Pandemic. The use of direct communication demonstrates this through the spokesperson and optimization of the use of social media to convey information and education to the public. This research provides academic and practical contributions related to Crisis Communication Strategies in the world of health and enriches the scientific treasures of Health Communication in Indonesia.
Comparison of treatment among pulmonary tuberculosis patients with and without Covid- 19 and the impact of type 2 DM
Authors: Fachri Muhammad , Hatta Mochammad , Ubaidah Firda Muthi , Akaputra Risky , Dwiyanti Ressy , Syukri Ahmad , Junita Ade Rifka , Febrianti Andini , Primaguna Muhammad Reza , Azhar Azhar 
Published: June 2023

Abstract
Background
The impact of the coronavirus disease 2019 (COVID-19) pandemic on tuberculosis (TB) was great enough for COVID-19 to replace TB as the leading cause of death worldwide. The WHO Global Tuberculosis Report 2020 stated that the number of TB cases reported was 845,000. The pandemic caused a decline in the detection of tuberculosis cases, and the attention of the Indonesian government became more focused on making COVID-19 a top priority in prevention and control measures so that tuberculosis cases were neglected.
Methods
This study used a cross-sectional. The research subjects were recruited using the consecutive sampling technique. The variable of this study was a comparison between pulmonary TB with confirmed COVID-19 and pulmonary TB without COVID-19 using the research subjects for total sampling. Bivariate analysis was used, which was carried out on two compared variables.
Results
Based on the results of this study, of the 127 samples studied, 101 pulmonary TB patients without COVID-19 and 26 pulmonary TB patients with confirmed COVID-19 were declared cured. This was observed more often among male patients than among female patients. Among TB patients with confirmed COVID-19, two age groups dominated, namely, the 17–25 (23.1%) and > 64 (23.1%) age groups. Moreover, most TB patients without COVID-19 were in the 26–35 age group (23.8%). The results of the length of treatment analysis among pulmonary TB patients without COVID-19 showed ≥ 6 months (82.2%) until these patients were cured. Moreover, the length of treatment for pulmonary TB patients with confirmed COVID-19 until they were declared cured was 7–9 months (61.5%). In this study, the number of pulmonary tuberculosis patients without COVID-19 who had type 2 DM (Diabetes Mellitus) was 77.1%.
Conclusions
The treatment period for pulmonary tuberculosis patients with confirmed COVID-19 was significantly longer than that for pulmonary tuberculosis patients without COVID-19.
Dietary connections of marine species to kelp and eelgrass
Authors: Chittaro Paul , Andrews Kelly , Tolimieri Nick , Gates Jonelle , Buckner Emily , Ylitalo Gina , Tonnes Dan 
Published: June 2023

Abstract
Ecosystem-based fisheries management requires an understanding of the interactions between managed and unmanaged species and the connections they have with their habitats. Although aquatic plants are known to provide important shelter for a variety of species, an often-overlooked component is the extent to which primary producers contribute to their diet. In this study, we reconstructed the dietary connections between 18 consumers, including vulnerable rockfish species, and several primary producers. Two of these primary producers, Zostera marina (eelgrass) and Nereocystis luetkeana (bull kelp), have experienced spatial variation in abundance and substantial declines, respectively, within Puget Sound, Washington, USA. Using stable isotope ratio data, we estimated that both bull kelp and Smithora naiadum (an epiphytic algae) were the most important sources of carbon in consumer diets, followed by particulate organic matter and eelgrass. Our results indicated strong dietary connections for certain consumers, such that epiphytic algae was found to comprise greater than 40% of the diets of copper rockfish (Sebastes caurinus), while bull kelp contributed most to the diets of Pacific staghorn sculpin (Leptocottus armatus) and quillback rockfish (S. maliger). For several consumers, we observed habitat-mediated prey choice because the relative importance of bull kelp or epiphytic algae in their diets increased when these consumers were collected from sites dominated by kelp or eelgrass, respectively. Understanding the strength of these trophic relationships is an important step for predicting ecosystem consequences following perturbations within these habitats, and such information is vital to managers making decisions related to the conservation of valuable populations.
A Novel Synergetic Process for Scandium Separation from Scandium Concentrate with Titanium Dioxide Wastewater
Authors: ZHONG Nanlan , Xiao Junhui , Deng Bing , Gao Deqiang , Zou kai 
Published: June 2023

Abstract
An effective process was proposed to extract scandium from a scandiumconcentrate with Sc2O3 content of 0.006624% and titanium dioxide wastewater with Sc content of 3.661 mg/L. After roasting and modified pretreatment of scandium Concentrate, the free acid in titanium dioxide wastewater is used as a leaching agent for the co-leaching of scandium. The result shows that: under the conditions of salt-free roasting, the roasting temperature of 850℃, roasting time of 2.0 h, leaching temperature of 80℃, leaching time of 2.0 h, leaching liquid-solid ratio of 8, leaching additive of NH4F and leaching additive consumption of 12%, the leaching results are optimal. A leaching efficiency of 83.90% can be reached. Meanwhile, the scandium content of the leaching residue decreases to 0.00115%. The SEM-EDS, XRD and Thermogravimetric analyses of scandium Concentrate, roasted ore and leaching residue show that: There will be two weight-loss phenomena during the roasting process. After roasting and modification, pyroxene and feldspar minerals can effectively decompose and release scandium element. It would create favourable conditions for the leaching of scandium with titanium dioxide wastewater and accomplish the purpose of synergic strengthening leaching and separation of scandium.
A new feedforward mechanism of Parkin activation
Authors: Lenka Dipti , Dahe Shakti , Sahoo Pritiranjan , Kumar Atul 
Published: June 2023

Abstract

Parkin E3-ligase is an auto-inhibited enzyme activated by phosphorylation of ubiquitin or ubiquitin-like (Ubl) domain of parkin by PINK1. Parkin mutations are known to affect its function leading to the onset of Parkinson’s disease. Herein, we show a competitive binding mode of the phospho-Ubl and RING2 domains on the RING0 domain, which regulates parkin activity. We show that phosphorylated parkin forms complex with native parkin leading to the activation of autoinhibited parkin in trans. Furthermore, we show that the activator element (ACT) of parkin is required to maintain the enzyme’s kinetics, and removal of ACT slows the enzyme catalysis. We also show that ACT can activate parkin in trans; however, it is more effective when present in the cis molecule. Furthermore, we identified and characterized a new donor ubiquitin binding pocket that plays a crucial role in parkin function.
NMRlipids Databank makes data-driven analysis of biomembrane properties accessible for all
Authors: Ollila Samuli , Kiirikki Anne , Antila Hanne , Bort Lara , Buslaev Pavel , Favela-Rosales Fernando , Ferreira Tiago , Fuchs Patrick , Garcia-Fandino Rebeca , Gushchin Ivan , Kav Batuhan , Kucerka Norbert , Kula Patrik , Kurki Milla , Kuzmin Alexander , Madsen Jesper , Miettinen Markus , Ricky Nencini , Piggot Thomas , Pineiro Angel , Suarez-Leston Fabian 
Published: June 2023

Abstract
Cellular membrane lipid composition is implicated in diseases and controls major biological functions, but membranes are difficult to study experimentally due to their intrinsic disorder and complex phase behaviour. Molecular dynamics (MD) simulations have been useful in understanding membrane systems, but they require significant computational resources and often suffer from inaccuracies in model parameters. Applications of data-driven and machine learning methods, currently revolutionising many fields, remain of limited use for membrane systems due to the lack of suitable training sets. Here we present the NMRlipids Databank—a community-driven, open-for-all database featuring programmatic access to quality-evaluated atom-resolution MD simulations of lipid bilayers. The NMRlipids Databank will benefit scientists in different disciplines by providing automatic ranking of simulations based on their quality against experiments, programmable interface for flexible implementation of data-driven and machine learning applications, and rapid access to simulation data through a graphical user interface. To demonstrate how it unlocks possibilities beyond current MD simulation studies, we analyzed the NMRlipids Databank to reveal how anisotropic diffusion of water and cholesterol flip-flop rates depend on membrane properties.
Effect of Intravenous N-acetylcysteine on Prevention of Mechanical Ventilation and Mortality among COVID-19 Patients: A Meta-Analysis
Authors: Claridad Karen Anne , Angeles Roland Reuben , Fernandez Lenora 
Published: June 2023

Abstract
BACKGROUND
COVID-19 is a looming disease that continuous to challenge medical systems all over the world due to its significant effect on morbidity and mortality. Early in the pandemic and even until present time, repurposing of a known drug significantly hasten the deployment of a novel approach for COVID- 19. One existing medication explored that could potentially provide invaluable treatment for COVID-19 is N-acetylcysteine (NAC) due to its antioxidant, anti-inflammatory and immune-modulating characteristics that has been hypothesized to modulate cytokine storm in patients with COVID-19.
OBJECTIVES
To investigate the effect of intravenous N-acetylcysteine in the prevention of mechanical ventilation and mortality among COVID-19 confirmed patients.
METHODS
A comprehensive literature search showed 7 records from which 5 were excluded and only 2 passed the inclusion and exclusion criteria. Two reviewers independently selected studies, assessed quality, and extracted and pooled outcomes. All selected studies were found to be of low risk of bias based on Review Manager Bias Assessment tool. Statistical analysis and forest plot generation were done using the Review Manager Software 5.3.
RESULTS
Pooled results showed a total of 227 patients in both NAC (n = 114) and control groups (n = 113) of COVID-19. There was no sufficient evidence to show that NAC prevents the need of mechanical ventilation among COVID-19 patients with odds ratio of 0.97 (95% CI, 0.54–1.74) and with p-value of 0.93. There was also no sufficient evidence to show that NAC prevents mortality among COVID-19 patients with odds ratio of 0.87 (95% CI, 0.44–1.7) and with p-value of 0.68.
CONCLUSION
NAC is an accessible, safe and highly tolerated drug used for many years already in patients with respiratory infection. This study showed that there is no sufficient evidence to prove that NAC prevents mechanical ventilation and mortality among COVID-19 patients and it’s use in resource limited areas cannot be recommended.
Physics-based 18-month lead forecast of Indian Summer Monsoon Rainfall
Authors: Sharma DEVABRAT , Das Santu , Chakraborty Deepayan , Mitra Adway , Goswami B. 
Published: June 2023

Abstract
Long-lead forecasts (6, 12, 18-month leads) of the Indian Summer Monsoon Rainfall (ISMR) are crucial for adaptive planning and damage minimization against climate change-induced increasing threats of higher frequency and intensity of hydrological disasters in the coming decades1–4. A recent study5 indicates that the ISMR is potentially predictable up to 24-months in advance as its variability is closely associated with the slowly varying Global El Niño and Southern Oscillation (G-ENSO). However, the growth of small initial errors and the chaotic nature of the climate system makes it formidable to achieve the ‘potential skill’ of long-lead ISMR forecasts by global Atmosphere-Ocean General Circulation Models (AOGCMs). Overcoming the challenge, here, we unravel a novel ‘hybrid long-lead forecast system’ for ISMR where predictor discovery is done using a deep learning Artificial Intelligence (AI) model trained on the nonlinear relationship between ISMR and the global depth of 20O isotherm (D20) from a large ensemble of AOGCMs and past observations. Our hybrid model demonstrates successful prediction capability of almost all ISMR droughts/floods at 18 and 5-month leads between 1980-2011. Our findings establish the physical basis and methodology for long-lead seasonal prediction of tropical systems like the ISMR and ENSO with unlimited socio-economic benefits.
Effect of dietary supplementation of Ganoderma lucidum residue on growth performance, immune organ index and faecal microbial community diversity in broiler chickens
Authors: Shi Chunfang , Guo Lipeng , Yang Huiting , Leng Xiaoyun , Deng Panbo , Bi Jie , Wang Yueming 
Published: June 2023

Abstract
Ganoderma lucidum residue (GLR) contains a variety of medicinal and nutritional components and is a potentially high quality roughage. The purpose of the experiment was to study the effects of GLR on the growth performance, immune function and intestinal flora of broilers. The study was conducted in a 90-day indoor cage experiment with broilers, and three feeding groups were set up with the addition of GLR to the basal diet at 0 (A), 10% (B) and 15% (C), with three replicates of 10 broilers in each group. The growth performance, immune organ index, and fecal microbial community structure of broiler chickens in different feeding groups were compared. The results showed that (1) there were no significant differences in the average daily weight gains of broilers in the different feeding groups. (2) The immune organ indices of broilers in Group B were higher than those in Groups A and C, with the spleen index in Group B being significantly higher than that in Group A. (3) The dominant phyla in the broiler faecal bacterial communities in all feeding groups were Firmicutes and Bacteroidetes, and the dominant genera were Lactobacillus, Bacteroides and Alistipes; however, the relative abundance of Bacteroidota was significantly higher in Group B than in Group A, and the relative abundances of Lactobacillus, Bacteroides and Alistipes were higher in Groups B and C than in Group A. (4) Manure microbial FAPROTAX functions predicted that GLR increased the abundances of heterotrophic and fermentative broiler manure microorganisms and significantly reduced the abundances of animal parasites or symbionts. In summary, group B was superior to other groups in terms of growth performance, spleen index and probiotic level. Adding GLR to the base feed has a positive effect on enhancing the immunity of broiler chickens, increasing the abundance of beneficial bacteria in the intestine, and maintaining the ecological balance of the intestinal flora. These findings reveal the effect of GLR on the fecal microorganisms of broiler chickens and provide a new development direction for improving poultry health.
Discerning Rise Time Constants to Quantify Charge Carrier Extraction in Perovskite Solar Cells
Authors: Ravishankar Sandheep , Kruppa Lennard , Jenatsch Sandra , Wang Yueming 
Published: June 2023

Abstract
The small-perturbation analysis of perovskite solar cells (PSCs) highlights a fundamental conundrum - while time domain measurements yield two time constants corresponding to the rise and subsequent decay of the photovoltage or photocurrent, the corresponding frequency domain methods only yield one time constant from the analysis of the imaginary part of the transfer function. To solve this problem, we propose a modification of the frequency domain transfer function that focusses on the transition of its real part to negative values at high frequencies. After verification using drift-diffusion simulations and equivalent circuit analysis, the application of the method to experimental intensity-modulated photovoltage spectroscopy data of a PSC allows calculation of the hidden rise time constant, showing a good agreement with rise time constants obtained from transient photovoltage measurements. The calculated rise time constants are indicators of the charge extraction efficiency of the contacts, that determines short circuit and low-bias recombination losses.
In vitro naive CD4+ T cells differentiation upon treatment with miR-29b-loaded exosomes from Mesenchymal Stem Cells
Authors: Bolandi Zohreh , Hashemi Seyed Mahmoud , Abasi Mozhgan , aghamiri Shahin , Ghanbarian hossein 
Published: June 2023

Abstract
Background: Gene regulation by microRNA is central in T cell differentiation processes. Here, we investigate miR-29b roles in the reprogramming of T cell differentiation, which can be a promising therapeutic avenue for various types of inflammatory disorders such as rheumatoid arthritis and multiple sclerosis.
Methods and Results: Adipose Mesenchymal Stem Cell derived exosomes (AMSC-Exo) enriched with miR-29b were delivered into naive CD4+ T cells (nCD4+) cells. The expression level of some important transcription factors including RORγt, GATA3, T-bet, and Foxp3 was determined by quantitative Real-Time PCR (qPCR). Moreover, flow cytometry and Enzyme-linked Immunosorbent Assay (ELISA) was respectively used to measure the frequency of T regulatory cells and the levels of cytokines production (IL-17, IL-4, IFN-γ, and TGF-β). This study indicates that the transfection of miR-29b mimics into T lymphocytes through AMSC-Exo can alter the CD4+ T cells differentiation into other types of T cells.
Conclusions: In conclusion, AMSC-Exo-based delivery of miR-29b can be considered as a new fascinating avenue for T cell differentiation inhibition and the future treatment of several inflammatory disorders.
Description of chest pain patients in the Emergency Department of a central hospital in Ajman
Authors: Fouda Ghada , Vallabh Kamil , Elbahrawi Magda 
Published: June 2023

Abstract
Chest pain accounts for 8 million visits to the Emergency Department annually, which contributes to 5% to 10% of all ED visits. A recent study revealed that between 2% to 5% of acute coronary syndrome patients visiting the emergency department were missed without being diagnosed correctly. Study design: retrospective cross-sectional study, we analyzed the database in SKGH emergency department for all patients presenting with chest pain, between November 2017 and October 2019, using SPSS program. Analysis included: Demographics: age, sex, country of origin and mode of arrival. Medical data: vital signs, triage grade, pain scale, seen within 72 hours or not, discharged within 7 days or not, final diagnosis and predisposition. Exclusion criteria: patients less than 18 years old. Two hundred patients met the inclusion criteria. Results: Mean age of the studied population was 49.22± 12.65, Male to female ratio was 2:1, mode of transport by Walking 94 (47%), private vehicle 50 (25%) and by ambulance 31(15.5%). Majority of patients were given triage 3 (moderate pain severity) 156 (78%), mean heart rate was 87.56 ± 17.97. One hundred three were diagnosed as nonspecific chest pain (51.5%), 27 (13.5%) were diagnosed as musculoskeletal chest pain. We found that 26 patients (13%) suffered from acute myocardial infarction (18 STEMI and 8 NSTEMI). Regarding the eighteen patients with STEMI 15 (83.3%) were males and 3 (16.7%) were females, 12 sent for PCI and 6 for thrombolysis. Admitted patients were 38 (19%) with different diagnoses.