bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the recipe composition of gluten-free flour confectionery products based on chickpea flour
Authors: Omaraliyeva Aigul , Botbayeva Zhanar , Agedilova Mereke , Abilova Meruyert , Nurtayeva Ainur , Baishugulova Shyryn 
Published: January 2023

The object of this study was gluten-free flour confectionery. In order to improve the structure of the assortment and create products for specialized purposes, the hypothesis was tested that ultra-high-frequency processing can help reduce the microbiological contamination of raw materials and improve the organoleptic characteristics of finished products. For this purpose, recipes for gluten-free flour confectionery products were developed, making it possible to obtain the best values of the specific volume of finished products – custard semi-finished products and gluten-free cupcake. Based on the implementation of second-order rotatable plans, regression models were built, and the resulting response surfaces were transformed to the canonical form. Based on this, it was established that the rational ratios of the components of the cupcake in the formulation are: 80 % flour from ultra-high-frequency processed chickpea flour, 15 % rice, and 5 % amaranth flour. The ratio of components of the custard semi-finished product from ultra-high-frequency processed chickpea flour and corn flour was approximately 50:50 %.
Prototypes of gluten-free flour confectionery products were produced, and the main quality indicators were determined. It was found that when flour from ultra-high-frequency processed chickpeas was introduced into the recipe of a cupcake from rice and amaranth flour, the amount of limiting amino acid lysine increased by 1.08 times compared to unprocessed chickpea flour. In the custard semi-finished product, the amount of the limiting amino acid arginine increased by 1.97 times compared to unprocessed chickpea flour. In general, the biological value of enriched cupcake and custard semi-finished product on average exceeds the control sample by 1.5 times.
In terms of safety, the developed gluten-free flour confectionery products meet the requirements of regulatory documentation.
The effectiveness of cytoprotection in the treatment of stable angina in patients with arterial hypertension and hyperuricemia, taking into account the peculiarities of the course of coronary artery disease in wartime
Authors: Iablonska Victoriia , Kholopov Leonid , Khyzhnyak Olena , Batashova-Halinska Viktoriia 
Published: January 2023

The aim of the study is to establish the effectiveness of treatment of severe angina pectoris in patients with hyperuricemia, taking into consideration the peculiarities of the course of coronary artery disease (CAD) in wartime, using ranolazine – a selective inhibitor of the late sodium flow in combined pharmacotherapy.
Materials and methods. We studied the anti-anginal effect of ranolazine in 14 patients with CAD, stable angina pectoris III-IV functional class (FC), hyperuricemia and arterial hypertension (AH) during 6 months of the 2022 year. The effectiveness of the study drug on the clinical course of angina pectoris was assessed by questionnaire and clinical examination after three months of treatment.
The results. At the end of the second week of ranolazine use, angina attacks at rest, which were registered before the start of the observation, stopped in all patients with angina pectoris III FC and 50 % with angina pectoris IV FC. In 78.6 %, the number of angina attacks and the use of nitrates decreased by more than 2 times; 21.4 % no longer had angina attacks.
At the end of the first month, anginal attacks were not observed in all patients with angina pectoris III FC and 50 % with angina pectoris FC IV. In 2 patients with angina pectoris IV FC (50 %), anginal attacks continued to be registered during physical exertion and emotional stress, but no more than once a week. At the same time, there were no angina attacks at rest. The same results were obtained during the survey of patients at the end of three months of observation.
Conclusions. Ranolazine is an effective component of anti-anginal therapy, significantly affecting the patient's quality of life. Therefore, we can recommend ranolazine for patients with hyperuricemia in angina attacks that persist with insufficient effectiveness of zasic therapy with first-line drugs, especially during military conflicts
Preparation and evaluation of lipid matrix microencapsulation for drug delivery of azilsartan kamedoxomil
Authors: Rahi Firas Aziz , Ameen Muath Sheet Mohammed , Jawad Krar Kadhim Mohammed 
Published: January 2023

The aim of the work is to consolidate azilsartan-kamedoxomil (AZM) into lipid matrix controlled-release microparticles to enhance its permeability because AZM belongs to Biopharmaceutical classification (BCS) IV which characterized by poor permeability and to protect AZM from light and humidity and execute a prolonged release profile.
Materials and methods. A reversed-phase HPLC method was created and validated to estimate the drug. AZM microparticles formulations were invented using melt dispersion technique and waxy materials such as carnuba wax, beeswax, stearic acid in the ratio of waxy-substance: drug ranging from 0.25: 1 to 1:1 and stabilizer namely; tween 80 and Poloxamer 407 in ratio of stabilizer: drug ranging from 0.5:1 to 1:1. Azilsartan formulations were assessed for azilsartan-medoxomil content, loading, entrapment efficiency, the zeta potential,the particle size, the morphology by scanning electronic microscopy (SEM), and in-vitro release profile.
Results. Zeta potential results for microparticle formulations using beeswax and carnuba range from -21.1 mV to -26.6 mV and -20.6 mV to -26.7 mV, respectively. This difference indicates that the azilsartan microparticles containing stearic acid are better stabilized with zeta potential of 25.3 - 29.7 mV. Furthermore, the release from azilsartan microparticle formulations containing stearic acid exceeded 80 % after 8 h and remained for 24 h while release from beeswax did not exceed 65 % after the same period and less than 60 % in case of carnuba formulations
Conclusions. The formulation (AZSP4) exhibited the highest zeta potential and released exceeding 80 % of AZM over the course of 8 hours and remained over a day. AZSP4 microparticles formulation containing, poloxamer 407, in a 0.8:0.8:1 drug: stearic acid: poloxamer ratio proved the ability of stearic acid microencapsulation employing poloxamer as stabilizer in a certain ratio can prolong the release of AZM
Disproportions of Supply and Demand in the Personnel Reproduction System for the Transport Industry
Authors: Vinichenko V. A. 
Published: January 2023

The modern system of personnel training for the transport industry has undergone significant changes after the collapse of the mechanism of graduates’ distribution and the transition to a three-level model of training in higher education. The permanent crisis in the educational environment has led to the emergence of supply and demand imbalances. The article analyzes the needs of the transport industry in the context of each segment (automobile, railway, water, air) and assesses the capabilities of the personnel training system for working in transport. The universities’ subordination has influenced the percentage of specialization of each of them and the share of students at the expense of budget allocations. The determination of the coefficients of paired regression shows a direct and quite a strong connection between the indicated parameters. The market capacity of the transport industry is assessed, showing that currently there are employees of aviation enterprises in excess. The other sectors are more or less deficient. The cohort-component method forecasts an even greater demographic deficit in the long term. There are generalized the results of personnel training by universities subordinate to the Ministry of Transport of the Russian Federation, as well as some quantitative parameters of the needs of transport enterprises.This research is an attempt to explain the imbalance between the demands of the transport industry and the capabilities of the higher education system. What seems practically important is that the study specifies the emerging disproportion in the context of individual sectors of the transport industry. This approach will probably allow the reader to make system management decisions for coordinating the educational process participants’ actions.
Dip range for intracontinental reverse fault ruptures: Truth not stranger than friction?
Authors: Sibson Richard H. , Xie Guoyuan 
Published: January 2023

AbstractHistograms of fault dips have been compiled for moderate to large (M &gt; 5.5) reverse-slip intracontinental earthquakes with the slip-vector raking 90 ± 30° in the fault plane. The principal data set is restricted to earthquakes where the fault plane in the focal mechanism can be unambiguously distinguished from the auxilliary plane; the reverse fault dips are bracketed within the range 12° &lt; δ &lt; 60° with a prominent peak in the 25° to 35° interval and a subsidiary peak in the 45° to 55° interval. Assuming horizontal trajectories for maximum compressive stress (σ1), the observed dip range is consistent with reactivation of faults possessing rock friction coefficients within Byerlee's (1978) range (0.85 &gt; μs &gt; 0.6), undergoing frictional lockup at dips approaching 60°. The broad 25° to 35° peak may arise from progressive domino steepening of imbricate reverse faults above the optimal dip for reactivation in regions undergoing bulk shortening. Paucity of very low-angle thrusts implies that it is generally the steeper ramps within ramp-flat assemblages that fail in moderate to large earthquakes. The subsidiary peak at 45° to 55° likely results from compressional reactivation of former normal faults in areas undergoing tectonic inversion, requiring some degree of fluid overpressuring. The results are consistent with previous studies on the dip range for active normal faults that again demonstrate frictional lockup at reactivation angles approaching 60°; together, these analyses suggest that “Byerlee” friction coefficients apply to faults with displacements of up to a few kilometers.
Morphological characteristics and expression of the S-100 protein in Purkinje cells of the cerebellum of a young and senile human
Authors: Balandin A. A. , Zheleznov L. M. , Balandina I. A. 
Published: January 2023

The problem of aging of the human body and the prevention of age-associated diseases in modern scientific literature is devoted to many studies. Researchers are showing increased interest in the aging of the cerebellum. Purkinje cells, which form the ganglionic layer of the cerebellar cortex, are considered to be very sensitive to various influences.The aim is to reveal the morphofunctional features of the Purkinje cells of the human cerebellum in the senile age in comparison with the young age.Material and methods. Morphological study of the cerebellum of 59 men and 52 women, right-handed, with anamnestic data that excluded diseases and injuries of the organs of the central and peripheral nervous system, as well as alcohol or drug addiction, was carried out during autopsy. The material for the study was taken from the region of the inferior semilunar lobule of the cerebellum. The studied material was divided into two groups: group I (n=59) included samples obtained from 31 men and 28 young women (from 25 to 32 years old inclusive), group II (n=52) – from 28 men and 24 women of senile age (from 79 to 88 years inclusive). We used general and neurohistological, immunohistochemical and morphometric research methods. Morphological assessment of Purkinje cells was carried out and the distance between their bodies was determined. An immunohistochemical study used a panel of antibodies to the S-100 protein.Results. A comparative analysis of the data obtained showed a statistically significant predominance of the distance between the bodies of Purkinje cells in the elderly compared to the young. Immunohistochemical study revealed an increase in the number of S-100-immunopositive Purkinje cells in old age.Conclusion. New data have been obtained on the age-related structural transformation of the cytoarchitectonics of the human cerebellar nervous tissue, which must be taken into account when studying age-associated diseases and movement coordination disorders.
The Pattern of Tuberculosis in Iran: A National Cross-Sectional Study
Authors: Doosti Adel , Nasehi Mahshid , Moradi Ghobad , Roshani Daem , Sharafi Saeed , Ghaderi Ebrahim 
Published: January 2023

Background: Despite of the remarkable achievement in control of tuberculosis, it is still a challenging health problem in Iran. Success in any health program depends on monitor the diseases epidemiology and finding the gaps. We aimed to describe the epidemiological profile of TB patients in Iran to find the gaps in the TB program and using the finding to set the program activities.
Methods: This cross-sectional study was performed based on the data of tuberculosis patients registered in Iran in 2016-2017. The information of all TB patients is registered in the TB registry software. The patients were followed during the treatment phase. The data were analyzed by SPSS 23 software using Chi-Square test.
Results: Overall 12% of cases were Afghans and 72.3% of patients had pulmonary tuberculosis. There was a significant difference in the success rate of treatment in smear-positive pulmonary patients by gender, HIV status, marital status, history of hospitalization and incarceration (P <0.01). The highest prevalence of antibiotic resistance was related to isoniazid (9.9%). In close contact persons who requiring prophylaxis, 65.3% of adults and 73.6% of children received full period of prophylaxis,
Conclusion: Despite of the TB treatment success and low prevalence of MDR cases, TB incidence has not been decreased significantly in Iran. Delay in diagnosis, high TB burden in refugees and close contact investigation and prophylaxis are important issues in the TB control program in Iran to be considered in the control planning.
Clustering of aqueous ethanol solutions. Qualitative approach
Authors: Chechko V.E. , Gotsulskyi V.Ya. 
Published: January 2023

The papers discuss the features of clustering in aqueous solutions of ethanol. It is assumed that the volume of an elementary cluster is smaller than the total molecular volumes of the components that make up this cluster. It is justified that the form of the concentration dependence of the cluster parameter. Based on the data on the cluster composition of water-ethanol solutions, the concentration dependence of was obtained. The value determination accuracy of does not worse than . Applying the group description of solutions, the concentration dependence of the molar volume of the solution in the concentration range was obtained. The deviation from experimental data is no more than. Obtained concentration dependence of contraction of aqueous solutions of ethanol at temperatures higher than. These dependences, in contrast to the contraction at temperatures lower than, do not pass through a special point of the solution.
Experimental studies of evaporation of paraffin drops
Authors: Orlovska S.G. 
Published: January 2023

Paraffin is a low-melting material that can be used as an environmentally friendly and high-energy fuel. It can also be considered as a promising material with phase transitions capable of accumulating heat. It is known that the period of induction of ignition of paraffin droplets consists of successive stages, the main ones of which are melting and evaporation. The paper examines the processes of evaporation of octadecane and docosane droplets in air at different temperatures. A method of studying the kinetics of evaporation of paraffin fuel droplets using digital photography of the research object and computer image processing has been developed.
It is proved that the evaporation kinetics of the studied alkanes is described by the linear law of the change of the square of the diameter of the drop over time. Evaporation rate constants were found. There are no such data in the literature for these paraffins. The use of evaporation constants made it possible to find the time of complete evaporation of drops and to estimate the diffusion coefficient of paraffin vapor in air at different temperatures. As a result of the experiments, it was established that the rate of evaporation of octadecane is more than 4 times higher than the rate of evaporation of docosane. It was found that when the air temperature reaches the specified values, the rate of evaporation of the specified alkanes increases significantly.
CONTRASTIVE REPRESENTATION OF CHARACTERS THROUGH THE CONTRASTIVE IMAGE OF THEIR CLOTHES IN THE NOVEL "ANNA KARENINA" BY LEO TOLSTOY
Authors: MURADIAN Iryna V. , VITYUKHOVSKAYA Alexandra V. 
Published: January 2023

The purpose of this article is to study the descriptions of the clothes of various opposing characters in the novel "Anna Karenina" by Leo Tolstoy. The object of this study is the lexemes used by Leo Tolstoy for describing the outfits of the heroes. The subject of the research is the ways of conveying the characters’ contrasts by using clothes as an important artistic detail. This study is based on the descriptions of Anna’s clothes and clothes of other characters of “Anna Karenina” novel. As a result of the study, the author comes to the following conclusions. Anna's clothes are marked with ordinary lexemes and are always in the background, being only a frame for the heroine. In contrast to Anna, the outfits of other characters are always in the foreground. Leo Tolstoy emphasizes that they are dressed according to the “extreme fashion”, uses lexemes of foreign origin in the description of their clothes. In contrast to the simplicity and naturalness of Anna, the pretentiousness and complexity of their outfits are emphasized.
PROSPECTS OF ONLINE EDUCATION FOR FOREIGN HIGHER EDUCATION ACQUIRES
Authors: Chernovaliuk Iryna 
Published: January 2023

Summary. The purpose of the study is to consider the features of online learning as a linguistic and didactic category of the modern educational space, to determine its main characteristics and methodological possibilities for its implementation in the education of foreign students. The object of the study is the process of online education of foreign students in higher education institutions. The subject of the study is the organization of the process of online education of foreign students and the content of its methodology. The main methods of research: analysis of scientific literature, questionnaires, testing, interviews with participants in the educational process, analysis of the content of educational programs and training plans, study of the learning experience of foreign students taking into account professional orientation. The research material was the theoretical works of linguists, methodologists, practicing teachers, as well as real online learning. The results of the research can be used in the process of designing a model of online education for foreign students, in improvement of a concept for the development of foreign students' language training, aimed at perfecting the system itself, improving the quality of education and training highly qualified specialists. The practical significance of the research consists in substantiation of pedagogical ways of perfecting and improving foreign language training of students and the conditions for their implementation in the educational process of a modern educational institution of higher education, the application of research data in the development of educational and methodological support, methodological materials and lecture courses for foreign students. The paper draws conclusions regarding the effectiveness of the use of new modern technologies and information and communication technologies for the purpose of developing and improving the language training system of foreign students. The prospects for creating effective online education for foreign students and using all the didactic possibilities of information and communication technologies have been clarified.
Empowerment of Indonesian MSME Business Performance: An Empirical Analysis of Knowledge Sharing and Innovation
Authors: Wahyuda Okta , A. Syukur M- Hanafi , Bagus Purmono Bintoro , Pebrianti Wenny , Setiawan Harry 
Published: January 2023

Abstract
The wheel of a country's economy is driven by the growth of Micro, Small, and Medium Enterprises (MSMEs). Structural socio-economic changes from MSME business activities can improve people's living standards, such as absorbing jobs, fostering a sustainable business climate, and equal distribution of people's income. Along with the increasing number of MSMEs, business actors are required to strengthen business performance through innovation orientation in the products they produce. Knowledge sharing is one of the competitive advantages built by the company so that MSMEs are guided in carrying out business activities. Acquiring knowledge and skills through collaboration is an effective and efficient effort to innovate in the business environment. This study examines knowledge sharing and product innovation in MSME performance management. The study used a quantitative method of 225 respondents based on purposive sampling criteria. The implementation of Structural Equation Modelling (SEM) with the AMOS 24 statistical tool was applied to test the feasibility of the data and research hypotheses.
Keywords: Knowledge Sharing; Product Innovation; Business Performance
Self-efficacy perceptions of teachers on using the Montessori method in special education in North Cyprus
Authors: Ender Devrim , Ozcan Deniz 
Published: January 2023

The aim of this study is to determine the self-efficacy perceptions of special education teachers about the use of the Montessori method by a valid and reliable scale developed by the researcher. The model of the research is a general descriptive model of quantitative research methods. In the 2017â€“2018 academic year, 67 special education teachers who work under the Directorate of Primary Education of the Ministry of National Education of the Turkish Republic of Northern Cyprus are participated in this research universe, which comprise 29, 12, 20, 4 and 2 teachers from Special Education Application Centre, Special Education and Work Application Centre, primary schools, kindergartens and school for visually impaired, respectively. This study was conducted only with all the special education teachers in the universe not by any sampling method. The general proficiency perceptions of the special education teachers for the use of the Montessori method were at the level of instability. According to the general competency perceptions of the female teachers on the use of the Montessori method, it was found that their responses were more positive than the males.
Keywords: Montessori method, self-efficacy scale, special education.