bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the chemical quality of sandy-textured soil and shallot (Allium cepa L.) yields using biochar and clay
Authors: Siregar Raesa Sakinah , Khusrizal  , Yusra  , Nasruddin  
Published: July 2023

Sandy soils are known as low-fertility soils due to the soil's limited physical, chemical, and biological properties. Rice husk biochar and clay soil are organic and inorganic materials that can improve soil quality levels. This study aims to improve the chemical quality of sandy soil and shallot crop yields using rice husk biochar and clay. The study was arranged using a factorial randomized block design, with rice husk biochar as the first factor and soil clay as the second factor. Rice husk biochar consisted of four levels, and three levels for clay. The chemical properties of the soil observed included pH, organic-C, cation exchange capacity (CEC), available-P (av-P), and exchangeable-K (K-ex). The yield of shallots was measured as the number of tubers and each tuber's wet and dry weight. The result showed that soil pH tended to vary and decreased from 6.9 in the initial soil to 6.4. Organic-C content increased from 0.11% initial soil to 0.31% and CEC from 6.80 cmolc/kg initial soil to 19.60 cmolc/kg. Av-P and K-ex levels varied and increased, where av-P increased from 97.65 mg/kg of the initial soil to 105.15 mg/kg, and K-ex levels increased from 0.20 cmolc/kg of the initial soil to 0.65 cmolc/kg. The combination of rice husk biochar and clay had no significant effect on the shallot yield. Rice husk biochar and clay could improve the chemical quality of sandy-textured soil. Both rice husk biochar and clay independently increase shallot yields.
STUDI KASUS : EFEKTIVITAS LATIHAN BATUK EFEKTIF TERHADAP BERSIHAN JALAN NAFAS PADA ASMA BRONKIAL DI IGD RUMAH SAKIT UMUM DAERAH KRATON PEKALONGAN
Authors: DS Petrus Nugroho , . Supriyo , . Sumarni , Amirudin Zaenal 
Published: July 2023

Latar Belakang : Asma merupakan penyakit saluran pernapasan yang tidak menular. Meskipun demikian asma perlu tetap perlu mendapat perhatian lebih. Salah satu hal yang dapat memperburuk kondisi asma adalah adanya penumpukan sekret. Penumpukan sekret dapat diencerkan dan dikeluarkan dengan terapi nebulizer ataupun pemberian obat pengencer dahak. Selain menggunakan obat pengeluaran sekret juga dapat dilakukan dengan menggunakan terapi non farmakologi yaitu dengan melakukan latihan batuk efektif.Metode : Penelitian ini menggunakan metode studi kasus. Penerapan latihan batuk efektif diberikan pada 15 orang responden. Setelah itu evaluasi akan dilakukan menggunakan lembar monitoring berbasis Standar Luaran Keperawatan Indonesia.Hasil : Hasil dari penelitian ini adalah adanya peningkatan kondisi responden. sebelum dilatih melakukan batuk efektif kondisi responden dalam rentang cukup dan baik. Setelah diajarkan latihan batuk efektif kondisi responden membaik dalam rentang baik dan sangat baik.Simpulan : Intervensi batuk efektif pada pasien dengan gangguan bersihan jalan napas dapat membantu pengeluaran sekret. Petugas kesehatan dapat mengajarkan latihan batuk efektif pada pasien. Petugas kesehatan juga diharapkan membuat media untuk mengajarkan batuk efektif pada pasien. Kata Kunci : batuk efektif, asma bronkhiale, gangguan bersihan jalan napas
Assessment of AI Enabled Case Simulations
Authors: Babin Ron 
Published: July 2023

<p>This research examines the ability of AI to help business students improve their understanding of teaching cases.</p>
<p>The research is from four years of trials, using a commercial AI software package, to create four simulations. The simulations are directly tied to the course curriculum and are designed to give students a better understanding of various business environments and personalities. </p>
<p>The research seeks to understand if AI enabled simulation helps students to gain a better understanding of the case, compared to a written (textbook) case. This is important for young students who have little or no business experience.</p>
<p>The cases focus on how information technology (IT) is used in business organizations. The business course is ITM100, a required first year course for all IT Management students at TMU. </p>
Antioxidant Activity Testing Combination of Moringa Leaf (Moringa oleifera L.) and Bambian (Ocimum sanctum L.) Leaves Extract Using DPPH Method
Authors: Dwijayanti Endah , Zoraida Masli Nurcahya , Kurnianingsih Siti Rahayu 
Published: July 2023

Research on the antioxidant activity combination of the ethanol extract of Moringa (Moringa oleifera L.) and basil (Ocimim sanctum L.) leaves has been carried out. The purpose of this study was to identify the content of secondary metabolites and measure the value of antioxidant activity as well as the maximum ratio of the combination of ethanol extract of Moringa leaves and basil leaves. The research methods include maceration extraction using 70% ethanol as a solvent, phytochemical screening using specific reagents and antioxidant activity testing using the DPPH method. The results of the phytochemical screening test for Moringa leaf extract and basil leaves were positive for containing chemical compounds of the flavonoid and tannin groups. The antioxidant activity test of Moringa leaf ethanol extract obtained IC50 results of 69.474 ppm which was categorized as a strong antioxidant, while basil leaves of 34.663 ppm which was categorized as very strong antioxidant, while the results of the combined study of antioxidant activity test of Moringa leaf ethanol extract and basil leaves obtained IC50 results at the ratio of 25:25 mg is 51.589 ppm and the ratio of 35:15 mg is 57.009 ppm which was categorized as a strong antioxidant, while at 15:35 mg is the optimum ratio because the IC50 result is 42.714 ppm which was categorized as very strong.
Boyarin, Adrienne Williams. The Christian Jew and the Unmarked Jewess: The Polemics of Sameness in Medieval English Anti-Judaism. Philadelphia: University of Pennsylvania Press, 2021.
Authors: Bunton Jim 
Published: July 2023

Review of Boyarin, Adrienne Williams. The Christian Jew and the Unmarked Jewess: The Polemics of Sameness in Medieval English Anti-Judaism. Philadelphia: University of Pennsylvania Press, 2021.
PEMANFAATAN APLIKASI MS. PROJECT DALAM PERENCANAAN PROYEK PADA PT. BERLIAN JAYA MANDIRI KONSULTAN
Authors: Leman Dedi , Cindy Paramitha Lubis  
Published: July 2023

Pembuatan jadwal proyek merupakan suatu hal yang penting karena dalam sistem penentuan jadwal telah diatur dalam perjanjian kontrak sebelum pengerjaan proyek dilaksanakan. Sehingga pihak perusahaan wajib membuat perhitungan pengerjaan sesuai dengan jadwal dan anggaran. Staf konsultan sering sekali memanfaatkan aplikasi Microsoft Excel karena dianggap lebih konvensional dari aplikasi yang lainnya. Akan tetapi, melalui pelatihan pengabdian kepada masyarakat dengan menggunakan aplikasi Microsoft Project diharapkan dapat memudahkan staf konsultan untuk membuat jadwal pengerjaannya lebih cepat dan efisien. Untuk mengetahui tingkat pemahaman dari peserta dilakukan ujian pretest dan posttest pada saat pelatihan dilakukan. Berdasarkan hasil posttest menyatakan bahwa staf konsultan dapat memahami pelathian dengan baik dengan tingkat pemahaman diatas 80%.
Analisis Sifat Mekanik Fe2O3 Undoping dan Doping Graphene sebagai Material Penguat pada Paduan Al-Si
Authors: Yazirin Cepi , Marlina Ena 
Published: July 2023

Aluminium memiliki berbagai aplikasi komersial karena memiliki ketahanan korosi yang baik, ringan, sifat mekanik yang baik, dan kemudahan fabrikasi. Paduan Aluminium-Silikon memiliki kemampuan cor dan las yang baik, konduktivitas termal yang baik, dan ketahanan korosi yang sangat baik. Semakin berkembangnya zaman, maka dunia industri saat ini dituntut untuk meningkatkan kualitas hasil produksinya. Tujuan dari penelitian ini adalah untuk mengetahui sifat mekanik paduan Al-Si setelah ditambahkan material lain. Metode penguatan pada paduan Al-Si menggunakan metode stir casting. Hasilnya Penambahan Fe2O3 undoping dan doping graphene tidak dapat meningkatkan kekuatan tarik dari paduan Al-Si dan sebaliknya penambahan Fe2O3 undoping dan doping graphene menurunkan kekuatan tarik dari paduan Al-Si. Penambahan material Fe2O3 undoping graphene dan Fe2O3 doping graphene pada paduan Al-Si memiliki pengaruh terhadap kekerasan paduan Al-Si yaitu terjadi peningkatan nilai kekerasan dari Al-Si raw 108,83 HV setelah ditambah material Fe2O3 undoping graphene menjadi 111 HV dan menjadi 134,83 HV setelah ditambah material Fe2O3 doping graphene.
Integrating scRNA and bulk-RNA sequencing develops a cell senescence signature for analyzing tumor heterogeneity in clear cell renal cell carcinoma
Authors: Gong Qiming , Jiang Yan , Xiong Junfeng , Liu Fahui , Guan Jikui 
Published: July 2023

IntroductionCellular senescence (CS) plays a critical role in cancer development, including clear cell renal cell carcinoma (ccRCC). Traditional RNA sequencing cannot detect precise molecular composition changes within tumors. This study aimed to analyze cellular senescence’s biochemical characteristics in ccRCC using single RNA sequencing (ScRNA-seq) and traditional RNA sequencing (Bulk RNA-seq).MethodsResearchers analyzed the biochemical characteristics of cellular senescence in ccRCC using ScRNA-seq and Bulk RNA-seq. They combined these approaches to identify differences between malignant and non-malignant phenotypes in ccRCC across three senescence-related pathways. Genes from these pathways were used to identify molecular subtypes associated with senescence, and a new risk model was constructed. The function of the gene DUSP1 in ccRCC was validated through biological experiments.ResultsThe combined analysis of ScRNA-seq and Bulk RNA-seq revealed significant differences between malignant and non-malignant phenotypes in ccRCC across three senescence-related pathways. Researchers identified genes from these pathways to identify molecular subtypes associated with senescence, constructing a new risk model. Different subgroups showed significant differences in prognosis level, clinical stage and grade, immune infiltration, immunotherapy, and drug sensitivity.DiscussionSenescence signature markers are practical biomarkers and predictors of molecular typing in ccRCC. Differences in prognosis level, clinical stage and grade, immune infiltration, immunotherapy, and drug sensitivity between different subgroups indicate that this approach could provide valuable insights into senescence-related treatment options and prognostic assessment for patients with ccRCC. The function of the gene DUSP1 in ccRCC was validated through biological experiments, confirming its feasibility as a novel biomarker for ccRCC. These findings suggest that targeted therapies based on senescence-related mechanisms could be an effective treatment option for ccRCC.
Prognostic model for hepatocellular carcinoma based on anoikis-related genes: immune landscape analysis and prediction of drug sensitivity
Authors: Zhang Dengyong , Liu Sihua , Wu Qiong , Ma Yang , Zhou Shuo , Liu Zhong , Sun Wanliang , Lu Zheng 
Published: July 2023

BackgroundHepatocellular carcinoma (HCC) represents a complex ailment characterized by an unfavorable prognosis in advanced stages. The involvement of immune cells in HCC progression is of significant importance. Moreover, metastasis poses a substantial impediment to enhanced prognostication for HCC patients, with anoikis playing an indispensable role in facilitating the distant metastasis of tumor cells. Nevertheless, limited investigations have been conducted regarding the utilization of anoikis factors for predicting HCC prognosis and assessing immune infiltration. This present study aims to identify hepatocellular carcinoma-associated anoikis-related genes (ANRGs), establish a robust prognostic model for HCC, and delineate distinct immune characteristics based on the anoikis signature. Cell migration and cytotoxicity experiments were performed to validate the accuracy of the ANRGs model.MethodsConsensus clustering based on ANRGs was employed in this investigation to categorize HCC samples obtained from both TCGA and Gene Expression Omnibus (GEO) cohorts. To assess the differentially expressed genes, Cox regression analysis was conducted, and subsequently, prognostic gene signatures were constructed using LASSO-Cox methodology. External validation was performed at the International Cancer Genome Conference. The tumor microenvironment (TME) was characterized utilizing ESTIMATE and CIBERSORT algorithms, while machine learning techniques facilitated the identification of potential target drugs. The wound healing assay and CCK-8 assay were employed to evaluate the migratory capacity and drug sensitivity of HCC cell lines, respectively.ResultsUtilizing the TCGA-LIHC dataset, we devised a nomogram integrating a ten-gene signature with diverse clinicopathological features. Furthermore, the discriminative potential and clinical utility of the ten-gene signature and nomogram were substantiated through ROC analysis and DCA. Subsequently, we devised a prognostic framework leveraging gene expression data from distinct risk cohorts to predict the drug responsiveness of HCC subtypes.ConclusionIn this study, we have established a promising HCC prognostic ANRGs model, which can serve as a valuable tool for clinicians in selecting targeted therapeutic drugs, thereby improving overall patient survival rates. Additionally, this model has also revealed a strong connection between anoikis and immune cells, providing a potential avenue for elucidating the mechanisms underlying immune cell infiltration regulated by anoikis.
Adherence, belief, and knowledge about oral anticoagulants in patients with bioprosthetic heart valve replacement: a cross-sectional study
Authors: Ni Yun-Xia , Liu Lu-Lu , Feng Huang , Li Zhi , Qin Chao-Yi , Chen Miao 
Published: July 2023

Aims: To investigate adherence to oral anticoagulants among patients after mechanical heart valve (BHV) replacement and further examine the mediating role of medication belief in the relationship between knowledge and medication adherence.Background: The number of patients who undergo BHV replacement has increased in recent years. Short-term anticoagulant therapy is recommended for patients after BHV replacement. However, little is known about adherence to oral anticoagulant therapy and the underlying mechanisms among patients with BHV replacement.Methods: A cross-sectional study was conducted between September 2022 and November 2022. A convenience sample of 323 patients who underwent BHV replacement was recruited from a tertiary public hospital in Southwest China. Data were collected by using the 8-item Morisky Medication Adherence Scale, Beliefs about Medicines Questionnaire-specific, and the Knowledge of Anticoagulation Questionnaire. The mediation model was tested by Hayes’s PROCESS macro. The STROBE checklist was used.Results: Approximately 17.3% of participants had low adherence, 47.1% had medium adherence, and only 35.6% reported high adherence to oral anticoagulants. Knowledge and necessity beliefs were positively related to medication adherence, while concern beliefs were negatively correlated with medication adherence. Medication belief mediated the relationship between knowledge and adherence to oral anticoagulants.Conclusion: Patients with BHV replacement demonstrated relatively low adherence to oral anticoagulant therapy. Efforts to enhance medication adherence should consider improving patients’ knowledge and medication beliefs.
Impact of living and working in the heat on cognitive and psycho-physiological responses in outdoor fly-in fly-out tradesmen: a mining industry study
Authors: Taggart Sarah M. , Girard Olivier , Landers Grant J. , Ecker Ullrich K. H. , Wallman Karen E. 
Published: July 2023

Objective: This study aimed to evaluate complex cognitive function, manual dexterity and psycho-physiological parameters in tradesmen working outdoors in the mining industry during summer and winter.Methods: Twenty-six males working in a mining village in the north-west of Australia were assessed pre- and post-an 11-h shift at the start, middle, and end of a 14-day swing in summer (average daily temperature: 33.9°C, 38% RH; n = 12) and winter (24.3°C, 36% RH; n = 14).Results: Working memory performance did not differ between seasons, over the swing or shift (p ≥ 0.053). Processing efficiency and manual dexterity performance did not differ between seasons (p ≥ 0.243), yet improved over the course of the swing (p ≤ 0.001) and shift (p ≤ 0.001). Core temperature, heart rate, thermal comfort, rating of perceived exertion and thermal sensation were not significantly different between seasons (p ≥ 0.076); however, average shift dehydration was greater in winter compared to summer (1.021 ± 0.005 vs. 1.018 ± 0.006; p = 0.014).Conclusion: The ability to self-regulate the intensity of activity likely helped outdoor workers to thermoregulate effectively, minimising thermal strain during their swings and shifts, in turn explaining unaltered cognitive function and manual dexterity performance between seasons. Regardless of season, workers should receive education on dehydration and workplace risks to protect their health.
Cloning and expression characterization of elongation of very long-chain fatty acids protein 6 (elovl6) with dietary fatty acids, ambient salinity and starvation stress in Scylla paramamosain
Authors: Lin Zhideng , Wu Zhouyu , Huang Chaoyang , Lin Huangbin , Zhang Mingyao , Chen Mingfeng , Han Kunhuang , Huang Weiqing , Ruan Shaojiang 
Published: July 2023

Introduction: Elongation of very long-chain fatty acids protein 6 (ELOVL6) played crucial roles in regulating energy expenditure and fatty acid metabolism. Many studies have performed to investigate the physiological roles and regulatory mechanisms of elovl6 in fish and animals, while few studies were reported in crustaceans.Methods: Here we reported on the molecular cloning, tissue distribution and expression profiles in response to dietary fatty acids, ambient salinity and starvation stress in Scylla paramamosain by using rapid amplification of cDNA ends (RACE) and quantitative real-time PCR.Results: Three elovl6 isoforms (named elovl6a, elovl6b and elovl6c) were isolated from S. paramamosain in the present study. The complete sequence of elovl6a was 1345 bp, the full-length sequence of elovl6b was 1419 bp, and the obtained elovl6c sequence was 1375 bp in full length. The elovl6a, elovl6b and elovl6c encoded 287, 329 and 301 amino acids respectively, and exhibited the typical structural features of ELOVL protein family members. Phylogenetic analysis showed that the ELOVL6a from S. paramamosain clustered most closely to ELOVL6 from Portunus trituberculatus and Eriocheir sinensis, while the ELOVL6b and ELOVL6c from S. paramamosain gathered alone into a single branch. Quantitative real-time PCR exhibited that the relatively abundant expression of elovl6b was observed in intestine and stomach, and the elovl6a and elovl6c were highly expressed in hepatopancreas. In addition, studies found that replacing fish oil with soybean oil could significantly increase the transcriptional levels of three elovl6 in hepatopancreas of S. paramamosain, and the expression of elovl6a and elovl6c in hepatopancreas were more sensitive to dietary fatty acids than the elovl6b. Compared with the normal sea water group (27‰), the expression of sterol-regulatory element binding protein1c (srebp-1), elovl6a, elovl6b and elovl6c were upregulated in the low salinity groups, particularly in 7‰. On the contrary, the starvation stress suppressed the expression of srebp-1, elovl6a, elovl6b and elovl6c.Discussion: These results may contribute to understand the functions of elovl6 in fatty acid synthesis and regulatory mechanisms in crustaceans.
Interactively learning behavior trees from imperfect human demonstrations
Authors: Scherf Lisa , Schmidt Aljoscha , Pal Suman , Koert Dorothea 
Published: July 2023

Introduction:In Interactive Task Learning (ITL), an agent learns a new task through natural interaction with a human instructor. Behavior Trees (BTs) offer a reactive, modular, and interpretable way of encoding task descriptions but have not yet been applied a lot in robotic ITL settings. Most existing approaches that learn a BT from human demonstrations require the user to specify each action step-by-step or do not allow for adapting a learned BT without the need to repeat the entire teaching process from scratch.Method:We propose a new framework to directly learn a BT from only a few human task demonstrations recorded as RGB-D video streams. We automatically extract continuous pre- and post-conditions for BT action nodes from visual features and use a Backchaining approach to build a reactive BT. In a user study on how non-experts provide and vary demonstrations, we identify three common failure cases of an BT learned from potentially imperfect initial human demonstrations. We offer a way to interactively resolve these failure cases by refining the existing BT through interaction with a user over a web-interface. Specifically, failure cases or unknown states are detected automatically during the execution of a learned BT and the initial BT is adjusted or extended according to the provided user input.Evaluation and results:We evaluate our approach on a robotic trash disposal task with 20 human participants and demonstrate that our method is capable of learning reactive BTs from only a few human demonstrations and interactively resolving possible failure cases at runtime.
n-3 PUFA-Enriched Diet Preserves Skeletal Muscle Mitochondrial Function and Redox State and Prevents Muscle Mass Loss in Mice with Chronic Heart Failure
Authors: Gortan Cappellari Gianluca , Aleksova Aneta , Dal Ferro Matteo , Cannatà Antonio , Semolic Annamaria , Guarnaccia Alberto , Zanetti Michela , Giacca Mauro , Sinagra Gianfranco , Barazzoni Rocco 
Published: July 2023

Rationale and Methods: Skeletal muscle derangements, potentially including mitochondrial dysfunction with altered mitochondrial dynamics and high reactive oxygen species (ROS) generation, may lead to protein catabolism and muscle wasting, resulting in low exercise capacity and reduced survival in chronic heart failure (CHF). We hypothesized that 8-week n-3-PUFA isocaloric partial dietary replacement (Fat = 5.5% total cal; EPA + DHA = 27% total fat) normalizes gastrocnemius muscle (GM) mitochondrial dynamics regulators, mitochondrial and tissue pro-oxidative changes, and catabolic derangements, resulting in preserved GM mass in rodent CHF [Myocardial infarction (MI)-induced CHF by coronary artery ligation, left-ventricular ejection fraction <50%]. Results: Compared to control animals (Sham), CHF had a higher GM mitochondrial fission-fusion protein ratio, with low ATP and high ROS production, pro-inflammatory changes, and low insulin signalling. n-3-PUFA normalized all mitochondrial derangements and the pro-oxidative state (oxidized to total glutathione ratio), associated with normalized GM cytokine profile, and enhanced muscle-anabolic insulin signalling and prevention of CHF-induced GM weight loss (all p < 0.05 vs. CHF and p = NS vs. S). Conclusions: n-3-PUFA isocaloric partial dietary replacement for 8 weeks normalizes CHF-induced derangements of muscle mitochondrial dynamics regulators, ROS production and function. n-3-PUFA mitochondrial effects result in preserved skeletal muscle mass, with potential to improve major patient outcomes in clinical settings.