bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cannabis use and perceptions among Canadians with Spinal Cord Injury
Authors: Ebrahimzadeh Sanam , Loh Eldon , Agudelo Alexandria Roa , Lawson Arden , Kassem Daad , Allison David 
Published: June 2023

Abstract
Design: A cross-sectional study was conducted based on an online survey among Canadian adults with any level or severity of SCI
Objectives: To understand aspects of cannabis use and perceptions among Canadians with spinal cord injury and describe the self-reported reasons and side effects of cannabis use.
Setting: Parkwood Institute at St Joseph’s Health Care London, the Power Cord SCI rehabilitation program at Brock University.
Methods: Participants were asked to complete a survey.
Results: 136 individuals were screened for participation, and 80 participants were enrolled. Of these participants, the majority (n=41 [51.2%]), indicated that they had tried cannabis in their lifetime, while 30 (37.5%) were current users. There was a non-significant increase (p=0.13) in cannabis use from pre (n=26, 32.5%) to post-injury (n=34, 42.5%). The most common reason for post-injury use was reducing pain (36.3%) and improving sleep (30%). Participants reported cannabis being moderately effective for both pain reduction and sleep improvement. Side effects were relatively mild and uncommon with the most frequently reported being fatigue both pre (7.5%) and post (11.3%) injury. Smoking was the most popular method of using cannabis before the injury (27.5%), while the preferred method after the injury was consuming edibles (26.3%).
Conclusions: Most participants who used cannabis before their injury continued using it after their injury. Participants reported recreational use before the injury, but they endorsed using cannabis to manage pain and medical conditions after injury and suggested that healthcare professionals should be aware of these findings. Additional research in this field is needed.
Uptake, Efflux, and Sequestration of Hg in the Asian Clam, Corbicula fluminea, at Environmentally Relevant Concentrations, and the Implications for Hg Remediation
Authors: Geeza Thomas Jeremy , Stevenson Louise Mote , Mathews Teresa Joan 
Published: June 2023

Abstract

Mercury is a persistent, ubiquitous contaminant that readily biomagnifies into higher trophic level species in aquatic environments across the globe. To better understand the bioaccumulation kinetics of aqueous Hg exposure in the invasive Asian Clam, Corbicula fluminea, a tank study was conducted at 3 treatment levels (20, 100, and 200 ng/L). These concentrations are lower than previous Hg uptake studies in clams, but more relevant to actual stream conditions. They represent the range of values commonly measured on several streams with legacy Hg contamination from past industrial operations, having undergone some remediation efforts to reduce Hg discharges. A biokinetic model, the first parameterized for Hg uptake in freshwater clams, was developed to describe uptake and efflux parameter and compared to previous parameter values estimated for other mollusk species. A decay model was used to account for rapid changes in concentration in the tanks due to Hg sorption to the container sides, a common issue in Hg empirical, lab-based studies. Results demonstrated that even at low Hg concentrations, Corbicula record signals of contamination through bioaccumulation, and both direct measurement and biokinetic models demonstrate large Hg bioaccumulation factors (as high as 1.34x105 mL/g dry tissue), similar to partitioning coefficients seen in engineered Hg sorbents.
The coupling of neuron-astrocyte lipid metabolism induced by neonatal hypoxic-ischaemic brain damage is ApoE dependent
Authors: hongyan chen , Shaozhi Zhao , Qiang Jian , Yinfang Yan , Simin Wang , Xinwen Zhang , Yuqiang Ji 
Published: June 2023

Abstract
The aim of this study was to investigate whether neonatal hypoxic-ischaemic brain damage induces lipid metabolism coupling between neurons and astrocytes and whether this mechanism is affected by ApoE isoforms. A neonatal rat model of hypoxic-ischaemic brain damage was established. Excessive accumulation of lipid droplets and upregulation of ApoE expression occurred in the hippocampus and cerebral cortex after ischaemia and hypoxia. In this glucose and oxygen deprivation (OGD) model of ApoE−/− primary neurons, compared with the addition of human recombinant ApoE2 and ApoE3 proteins, the ApoE4 protein significantly reduced neuronal cell viability and the efficiency of lipid transport from neurons to astrocytes after OGD. Notably, the ApoE mimic peptide COG133 could compensate for the harmful effects of ApoE4. In conclusion, lipid metabolism coupling between neurons and astrocytes occurs and is the key to protecting neurons from stress injury after hypoxia-ischaemia; however, ApoE4, as a negative factor, plays a detrimental role in regulating the fatty acid metabolism of neurons and astrocytes and may be a potential target for the clinical treatment of neonatal hypoxic-ischaemic encephalopathy.
Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
Authors: Liu Kun , Gao Qiong , Jia Yuzhi , Wei Juncheng , Chaudhuri Shuvam , Wang Shengnan , Tang Amy , Mani Nikita , Iyer Radhika , Cheng Yang , Gao Beixue , Lu Weiyuan , Sun Zhaolin , Liu Huiping , Fang Deyu 
Published: June 2023

Abstract
Integrins plays critical roles in connecting the extracellular matrix and actin skeleton for cell adhesion, migration, signal transduction, and gene transcription, which upregulation is involved in cancer stemness and metastasis. However, the molecular mechanisms underlying how integrins are upregulated in cancer stem cells (CSCs) remain as a biomedical mystery. Herein, we show that the death from cancer signature gene USP22 is essential to maintain the stemness of breast cancer cells through promoting the transcription of a group of integrin family members in particular integrin β1 (ITGB1). Both genetic and pharmacological USP22 inhibition largely impaired breast cancer stem cell self-renewal and prevented their metastasis. Integrin β1 reconstitution partially rescued USP22-null breast cancer stemness and their metastasis. At the molecular level, USP22 functions as a bona fide deubiquitinase to protect the proteasomal degradation of the forkhead box M1 (FoxM1), a transcription factor for tumoral ITGB1 gene transcription. Importantly unbiased analysis of the TCGA database revealed a strong positive correlation between the death from cancer signature gene ubiquitin-specific peptidase 22 (USP22) and ITGB1, both of which are critical for cancer stemness, in more than 90% of human cancer types, implying that USP22 functions as a key factor to maintain stemness for a broad spectrum of human cancer types possibly through regulating ITGB1. To support this notion, immunohistochemistry staining detected a positive correlation among USP22, FoxM1 and integrin β1 in human breast cancers. Collectively, our study identifies the USP22-FoxM1-integrin β1 signaling axis critical for cancer stemness and offers a potential target for antitumor therapy.
Analysis of the influence of online emotional comments on product sales based on multiple regression model
Authors: Guo Kaiqiang , Cao Li 
Published: June 2023

Abstract
Based on Sentiment analysis and Empirical analysis, this research studies the impact that online reviews have on product sales in the context of movie industry. Firstly, finding the feature words of movie; secondly, using fuzzy statistics to identify the emotional intensity of evaluation words, and calculating the value of feature evaluation; finally, developing the multivariate regression model to analyze the impact of online reviews on product sales by importing the value of feature evaluation. The results show that reviews number, value of story evaluation, and value of act evaluation has significant influence on the box office revenue (product sales), furthermore, the model with value of feature evaluation have better goodness-of-fit than the model with reviews rating, confirming the sentiment analysis of online reviews has great practical implications.
Absence of female preference and the origin of a unisexual species, the Amazon molly (Poecilia formosa)
Authors: Smith Caden , de Filho Waldir Miron Berbel , Spikes Montrai , Fyon Frederic , Ubeda Francisco , Schlupp Ingo 
Published: June 2023

Abstract

The role of hybridization as a formative process in evolution has received much attention in the past few decades. A particularly fascinating outcome of hybrid speciation is the formation of asexual hybrid species. This is the case in the Amazon molly (Poecilia formosa). It is of hybrid origin and had a P. mexicana female as mother and a P. latipinna male as father. This implies that at the beginning of the existence of Amazon mollies, a heterospecific mating must have occurred, indicating a breakdown of any potential prezygotic isolation between parental species. We studied the female mate choice behavior with present day P. mexicana and P. latipinna from several populations using standard binary choice tests. Overall, our results show that in extant P. mexicana and P. latipinna no female choice for conspecific males was detectable. Consequently, heterospecific matings are possible, even likely, and not hindered by any apparent behavioral prezygotic isolation. If female preferences in these species were comparable around the time the Amazon molly originated as a hybrid species ca. 100.000 years ago, matings leading to hybrids would be very likely. Furthermore, for the first time we tested the mating preferences of F1 hybrid females and found that they also have no discernable mating preferences, potentially leading to F2 individuals and/or backcrosses.
Screening and Identification of key biomarkers associated with amyotrophic lateral sclerosis and depression using bioinformatics
Authors: Wang Ziyue , Yang Hao , Han Yu , Teng Jing , Kong Xinru , Qi Xianghua 
Published: June 2023

Abstract
Objective
This study aims to identify common molecular biomarkers between amyotrophic lateral sclerosis (ALS) and depression using bioinformatics methods, in order to provide potential targets and new ideas and methods for the diagnosis and treatment of these diseases.
Methods
Microarray datasets GSE139384, GSE35978, and GSE87610 were obtained from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) between ALS and depression were identified. After screening for overlapping DEGs, gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Furthermore, a protein-protein interaction (PPI) network was constructed using the STRING database and Cytoscape software, and hub genes were identified. Finally, a network between miRNAs and hub genes was constructed using the NetworkAnalyst tool, and possible key miRNAs were predicted.
Results
A total of 357 genes have been identified as common DEGs between ALS and depression. GO and KEGG enrichment analyses of the 357 DEGs showed that they were mainly involved in cytoplasmic translation. Further analysis of the PPI network using Cytoscape and MCODE plugins identified 6 hub genes, including MRPS12, PARP1, SNRNP200, PCBP1, SGSM1, and DNMT1. Five possible target miRNAs, including miR-221-5p, miR-21-5p, miR-100-5p, miR-30b-5p, and miR-615-3p, were predicted by constructing a miRNA-gene network.
Conclusion
This study used bioinformatics techniques to explore the potential association between ALS and depression, and identified potential biomarkers. These biomarkers may provide new ideas and methods for the early diagnosis, treatment, and monitoring of ALS and depression.
Level of noise-induced hearing loss and associated factors among workers in Bishoftu central air base of Ethiopia
Authors: Hailu Ashenafi , Zeleke Birhanu , Ermias Zeberihe , Fasil Kenea , Dula Sara , Wakuma Samson , mekonen Seblework , Tucho Gudina Terefe , Afata Tariku Neme 
Published: June 2023

Abstract

Background
Excessive occupational exposure to noise results in occupational hearing loss was considered a major public health problem. Since the expansion of the aviation industry and its exposure to the intensity of noise level was simultaneously high.
Objective
This study aims to assess the level of noise-induced hearing loss and associated factors among workers in the Bishoftu central air base in Ethiopia.
Methods
Institutional-based cross-sectional study was conducted among 260 central air base workers through face-to-face interviews; an environment noise survey with an audiometric test had been conducted to collect data. Data were entered by Epidata version 3.1 and SPSS was used to analyze the data. Finally, a statistical analysis such as descriptive statistics and binary logistic regression analysis was applied. A P-value < 0.05 at 95%CI was considered statistically significant.
Result
The overall prevalence of noise-induced hearing loss and hearing impairments were 24.6 and 30.9%, respectively. From this, 16.9% bilateral and 7.7% unilateral noise-induced hearing loss. The highest prevalence noise level was recorded for workers who were exposed to noise levels greater than 90 dBA. Around 21.9% were males with an age category between 18 to 27 years were exposed to noise-induced hearing loss. Similarly, the lowest experience was between 1 to 10 years of exposure to noise-induced hearing loss by 16.9% with working department transport helicopter (4.7%), transport airplane (4.7%), and daily maintenance (3.5%). Those participants who were exposed to noise-induced levels at work place previously were five times (AOR = 5.0, 95% CI: 1.74–14.36) more likely exposed to the sound noise level at the workplace than those workers not exposed at work place previously. Those workers who were exposed to greater or equal to 90dBA noise level were 4.98 times (AOR = 4.98, 95% CI: 2.59–9.58) more likely exposed to noise-induced levels than those who were exposed to less than 90dBA noise level. Moreover, male air base workers were 3.5 times more likely exposed to hearing impairment than female workers (AOR = 3.5, 95%CI 1.01–12.0) and participants who have abnormal otologic examinations were 1.9 times more likely exposed to hearing impairment than those who have normal otologic examinations (AOR = 1.9, 95%CI 1.02–3.54).
Conclusion
Workers were exposed to high levels of occupational noise that could induce immediate hearing loss. The prevalence of hearing loss was significantly high.
Prevalence and Determinants of Stunting Risk Factors among Children Under Five Years Old: An Analysis of the Indonesian Secondary Database
Authors: Nurdin Asrawati , Masrul Masrul , Gusnedi Gusnedi , Umar Hermita Bus , Purnakarya Idral , Syafrawati Syafrawati , Andrafikar Andrafikar , Novianti Novianti , Susilowati Andi , Nindrea Ricvan Dana , Lipoeto Nur Indrawaty 
Published: June 2023

Abstract

Background Stunting among children under five remains a global health problem. Indonesia is no exception, as its stunting reduction rate has not yet reached the expected target. Regencies/cities in the West Sumatra province in Indonesia still show a stark disparity of achievement following the implementation of their various stunting prevention policies and programs.Methods Cross-sectional study based on 2018 Riskesdas and 2021 SSGI. Nineteen regencies/cities in West Sumatra province. Families with children under five years involved 3,380 subjects from the 2018 Riskesdas and 4,662 subjects from the 2021 SSGI.Results The results showed that the stunting prevalence decreased from 31.2% in 2018 to 23.3% in 2021. Stunting risk factors include male gender, low birth weight, mothers over 35 years, upper respiratory tract infection, lack of vitamin A consumption, and parents’ low education. The rate of stunting reduction varies significantly between cities or regencies in the West Sumatra province due to non-exclusive breastfeeding, lack of growth monitoring, poor water quality, and working mothers.Conclusions Most stunting occurs before the age of two. Stunting is significantly influenced by various infectious diseases, dietary intake, and parents' socioeconomic status. The related city/regency governments should develop intervention strategies and specific programs to reach the expected target.
Genome-wide identification of GATA transcription factor family and the effect of different light quality on the accumulation of terpenoid indole alkaloids in Uncaria rhynchophylla
Authors: Shao Yingying , Zhou Yu , Yang Li , DeTian Mu , W Wilson Iain , Zhang Yao , Zhu Lina , Liu Xinghui , Luo Ling , He Jialong , Qiu Deyou , Tang Qi 
Published: June 2023

Abstract
Uncaria rhynchophylla is an evergreen vine plant, belonging to the Rubiaceae family, that is rich in terpenoid indole alkaloids (TIAs) that have therapeutic effects on hypertension and Alzheimer's disease. GATA transcription factors (TF) are a class of transcription regulators that participate in the light response regulation, chlorophyll synthesis, and metabolism, with the capability to bind to GATA cis-acting elements in the promoter region of target genes. Currently the GATA TF family in U. rhynchophylla has not been investigated. In this study, 25 UrGATA genes belonging to four subgroups were identified based on genome-wide analysis. Intraspecific collinearity analysis revealed that only segmental duplications were identified among the UrGATA gene family. Collinearity analysis of GATA genes between U. rhynchophylla and four representative plant species, Arabidopsis thaliana, Oryza sativa, Coffea Canephora, and Catharanthus roseus was also performed. U. rhynchophylla seedlings grown in either red lights or under reduced light intensity had altered TIA content after 21 days. Gene expression analysis reveal a complex pattern of expression from the 25 UrGATA genes as well as a number of key TIA enzyme genes. UrGATA7 and UrGATA8 were found to have similar expression profiles to key enzyme TIA genes in response to altered light treatments, implying that they may be involved in the regulation TIA content.
FSRD:Few-shot fuzzy rumor detection system with stance-enhanced prompt learning
Authors: Li Hao , Yang Wu , Wang Huanran , Wang Wei 
Published: June 2023

Abstract
Rumor detection is a classification task that uses information including the content of a rumor, the comments surrounding it, and information about the users involved. In existing social networks, rumors are usually emergent and often about unknown events, leading researchers to consider tasks in low-resource situations, including early rumor detection and unknown rumor detection. Existing approaches require constructing rumor representations based on the entire propagation cycle of rumors or specific features of current events. They can lead to models that are too dependent on existing data features and lack generality in low-resource situations and are not suitable for real-world environments that are constantly changing.
This paper proposes prompt-learning based on few-shot and zero-shot rumor fuzzy detection systems FSRD. These two types of methods can detect rumors in a variety of low-resource scenarios (e.g., early rumor detection, unknown rumor detection) using only a small amount of source rumors with the help of better explainable prompt templates, without waiting for rumors to spread to obtain more features.
On several standard rumor detection datasets, FSRD outperforms various other detection methods for few-shot scenarios, and achieves competitive results on zero-shot tasks as well.
Inhibitory Control Training Improves Cold but Not Warm Cognition
Authors: Nejati Vahid , Ghotbi Ladan , Raskin Sarah 
Published: June 2023

Abstract
Inhibitory control, as a fundamental executive function, has been found to be associated with a range of cognitive processes. In this study, our objective was to enhance inhibitory control through a targeted training program and assess its impact on delay discounting and risky decision making. Thirty-two typically-developing children (age mean 6.89±0.32 years) were recruited in a random clinical trial design in two equal intervention and active control groups. Go/No-Go, Flanker, continuous performance, delay discounting, and balloon analogue risk tasks were used for assessment in three baseline, post- intervention, and 1-months follow-up sessions. The intervention group received the program for attentive rehabilitation of inhibition and selective attention (PARISA) and the active control group participated in a story telling class, both in 12 sessions. The results of the study indicate significant improvements in sustained attention, interference control, and prepotent inhibition among participants in the intervention group. However, there were no significant changes observed in delay discounting and risky decision making. These findings suggest that the inhibitory control training primarily enhances aspects of cold cognition and attentional processes. However, the observed improvements did not extend to reward processing or warm cognition.
Intraspecific variability in cold hardiness of Taurus Cedar (Cedrus libani A. Rich.) in Türkiye
Authors: İmal Bora , Semerci Akkın , Gonzalez-Benecke Carlos A. 
Published: June 2023

Abstract

To better guide Cedrus libani provenances movement to northerly and higher altitudes sites for afforestation, the limits of hardiness to cold should be better known. In this study, we quantified the cold hardiness of seven C. libani provenances sampled from a provenance trial in Ankara, Türkiye, a site located outside the natural range of distribution of the species. Visual damage observation and chlorophyll fluorometry screening methods were used to assess variation in cold hardiness (LT50, the temperature estimated at which 50% of the needle tissue is damaged) among populations. Overall, C. libani can tolerate winter temperatures up to -21°C. Even though there were significant differences in cold hardiness among populations, the maximum difference was only 1.9°C between the most and the least cold-resistant provenances. Cold tolerance was generally greater for provenances that experienced colder temperatures in March and lower levels of total precipitation in their native ranges. We also conclude that the fluorometry method provides a more efficient and stable comparison of cold hardiness than visual observation for C. libani. The results of this study may be useful for assisted migration and breeding programs, as well as for developing guidelines for genetic materials transfer, to increase productivity or adaptability of C. libani.
The Roles of Plant-derived Nanovesicles in Malignant Tumours: a bibliometric analysis
Authors: Wang Dandan , Mei Zifan , Zhao Tingting , Tian Hao , Peng Zaihui , Kang Xia , Zhang Yi , Qi Xiaowei 
Published: June 2023

Abstract
Malignant tumours remain one of the most intractable health problems worldwide. Recently, plant-derived nanovesicles (PDNVs) have been used as an emerging tool in the treatment of malignant tumours due to their high biosafety. This paper presents a systematic review of the research progress of PDEVs in malignant tumours based on bibliometric analysis. In this review, the research on PDEVs in malignant tumours was identified and analyzed through various countries/institutions, authors, references and research hotspots. In addition, the different biological functions and applications of PDNVs from different sources in malignant tumours by themselves or as carriers were summarized. Finally, the application prospect of PDEVs in malignant tumours is prospected. The purpose of this paper is to summarize the research progress of the role of PDEVs in malignant tumours, and to provide new ideas and clues for overcoming the difficulties of tumour treatment.