bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of RegCM4.7‐CLM precipitation and temperature by improved bias correction methods over Central Africa
Authors: Mbienda A. J. Komkoua , Guenang G. M. , Kaissassou S. , Tanessong R. S. , Choumbou P. C. , Giorgi F. 
Published: February 2023

AbstractPrecipitation and temperature projections from Regional Climate Models (RCMs) over Central Africa (CA) are of great importance. However, several studies have already shown that the data from RCMs cannot be directly used for climate impact studies on a local scale because of systematic biases that characterize them. Therefore, RCM simulations must be preprocessed in order to make them more representative of climate at a local scale. The present study focuses on improving temperature and precipitation simulations from the RegCM4.7 RCM over CA. For this purpose, two correction methods are used: The adjusted Linear Scaling and Variance (Va) methods. Corrected and uncorrected precipitation and near‐surface temperature are compared with Climate Hazards group Infrared Precipitation with Stations (CHIRPS) and the fifth generation of ECMWF reanalysis data (ERA5), respectively. Comparison of the performances of both methods was made during various seasons not only over the whole CA region but also over two sub‐domains (Zones 1 and 2) having different characteristics. This was done on the basis of the mean bias and Root Mean Square Error. Results show that the precipitation from RegCM4 is tainted with huge wet biases compared to CHIRPS. Overall, the analysis suggests that the Va method is the most suitable for reducing the biases of RegCM4.7 simulations, particularly for precipitation irrespective of regions or seasons. However, it has been found that both methods fail to improve temperature biases in the Inter‐Tropical Convergence Zone.
Molecular pathogenesis of a novel Met394Thr variant causing hemophilia B
Authors: Lu Linna , Wang Lingyu , Shen Wukang , Fang Shuai , Zhao Lidong , Hu Xuchen , Yang Linhua , Wang Gang 
Published: February 2023

AbstractBackgroundHemophilia B (HB), a rare bleeding disorder, shows X‐linked recessive inheritance and is caused by heterogeneous variants in the FIX gene (F9) encoding coagulation factor IX (FIX). This study aimed to investigate the molecular pathogenesis of a novel Met394Thr variant causing HB.MethodsWe used Sanger sequencing to analyze F9 sequence variants in members of a Chinese family with moderate HB. Subsequently, we performed in vitro experiments on the identified novel FIX‐Met394Thr variant. In addition, we performed bioinformatics analysis of the novel variant.ResultsWe identified a novel missense variant (c.1181T>C, p.Met394Thr) in a Chinese family with moderate HB in the proband. The proband's mother and grandmother were carriers for the variant. The identified FIX‐Met394Thr variant did not affect the transcription of F9 and the synthesis and secretion of FIX protein. The variant may, therefore, affect the physiological function of FIX protein by disrupting its spatial conformation. In addition, another variant (c.88+75A>G) in intron 1 of F9 was identified in the grandmother, which may also affect FIX protein function.ConclusionWe identified FIX‐Met394Thr as a novel causative variant of HB. Further understanding of the molecular pathogenesis underlying FIX deficiency may guide novel strategies for precision HB therapy.
Phenolic resin microspheres surface‐modified with sodium silicate for reducing fire hazard in TPU composites
Authors: Wang Yaxuan , Zhang Yanli , Feng Tingting , Teng Anqi , Ren Jinyong , Piao Junxiu , Wang Yaofei , Jiao Chuanmei , Chen Xilei 
Published: February 2023

AbstractIn this article, a sodium silicate surface‐modified phenolic resin microsphere (SSMPHM) was prepared to reduce the fire hazard of thermoplastic polyurethane (TPU). The characterization results demonstrated that sodium silicate was successfully deposited on the surface of the phenolic resin microsphere (PHM). The results of the combustion test demonstrated that the introduction of SSMPHM remarkably reduced the fire hazard of thermoplastic polyurethane (TPU) composites (e.g., ∼66.0% and 77.0% decline in peak heat release rate (pHRR) and smoke factor (SF) at 4 wt% content (TPU/SSM‐4)). At the same time, the peak value of COP reduced from 0.029 to 0.009 g s−1 compared with TPU. The results of condensed phase analysis demonstrated that compared with TPU, the char residue layer of TPU/SSM‐4 was relatively dense and continuous. In addition, mechanical performance tests showed that SSMPHM could make up for the loss of mechanical performance caused by PHM. The work provides new insights into modifying PHM for effectively reducing the fire hazard of TPU.
A systematic review and meta‐analysis of psychosocial interventions for immigrant and limited English proficient cancer patients
Authors: Lui Florence , Lewicka Malwina , Bao George C. , Moyer Anne , Boyce Lindsay , Leng Jennifer 
Published: February 2023

AbstractObjectiveImmigrants, particularly those who are less acculturated and limited English proficient (LEP), often lack access to culturally and linguistically appropriate psychosocial care in cancer survivorship. We sought to determine what psychosocial interventions are available for immigrant and/or LEP cancer patients and to assess treatment and patient factors that may correlate with better psychosocial outcomes for this population.MethodsWe conducted a systematic review and meta‐analysis of studies published through August 2022 of interventions conducted with immigrant and/or LEP cancer patients aimed at improving psychosocial outcomes (i.e., quality of life, depression, cancer‐related distress, and anxiety). Using Covidence, a software program for systematic review management, four independent raters screened 16,123 records with a systematic process for reconciling disagreement, yielding 48 articles (45 studies) for systematic review and 21 studies for meta‐analysis.ResultsMost studies were conducted with Spanish‐speaking patients with breast cancer. Study participants (N = 5400) were primarily middle‐aged (mean = 53 years old), female (90.0%), and Hispanic (67.0%). The weighted average effect size (g) across studies was 0.14 (95% CI 0.03–0.26) for quality of life (18 studies), 0.04 (95% CI −0.08 to 0.17) for depression (8 studies), 0.14 (95% CI −0.03 to 0.31) for cancer‐related distress (6 studies), and 0.03 (95% CI −0.11 to 0.16) for anxiety (5 studies).ConclusionThe interventions under review had small but beneficial effects on psychosocial outcomes for immigrant and LEP cancer patients. Notably, effect sizes were smaller than those found in previous meta‐analyses of psychosocial interventions conducted in majority U.S.‐born, non‐Hispanic White, English‐speaking cancer patient samples. More research is needed to identify key components and adaptations of interventions that benefit immigrant and LEP cancer patients to strengthen their effects for this growing yet underserved population.
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway
Authors: He Cheng‐Hui , Lv Jia‐Min , Khan Ghulam Jilany , Duan Hong , Wang Wei , Zhai Ke‐Feng , Zou Guo‐An , Aisa Haji Akber 
Published: February 2023

AbstractDracocephalum Moldavica L. is a traditional herb for improving pharynx and relieving cough. However, the effect on pulmonary fibrosis is not clear. In this study, we explored the impact and molecular mechanism of total flavonoid extract from Dracocephalum moldavica L. (TFDM) on bleomycin‐induced pulmonary fibrosis mouse model. Lung function testing, lung inflammation and fibrosis, and the related factors were detected by the lung function analysis system, HE and Masson staining, ELISA, respectively. The expression of proteins was studied through Western Blot, immunohistochemistry, and immunofluorescence while the expression of genes was analyzed by RT‐PCR. The results showed that TFDM significantly improved lung function in mice, reduced the content of inflammatory factors, thereby reducing the inflammation. It was found that expression of collagen type I, fibronectin, and α‐smooth muscle actin was significantly decreased by TFDM. The results further showed that TFDM interferes with hedgehog signaling pathway by decreasing the expression of Shh, Ptch1, and SMO proteins and thereby inhibiting the generation of downstream target gene Gli1 and thus improving pulmonary fibrosis. Conclusively, these findings suggest that TFDM improve pulmonary fibrosis by reducing inflammation and inhibition of the hedgehog signaling pathway.
Reliability modeling of competing failure processes with multi‐stage degradation
Authors: Li Long , Yu Tianxiang , Shang Bolin , Song Bifeng , Chen Yijian 
Published: February 2023

AbstractIn this paper, reliability models of competing failure processes for the product subject to degradation and random shocks are established, which are accompanied by degradation path slope change caused by specific shock patterns. The two related failure modes are hard failure arising from different random shocks, and soft failure due to consecutive structure damage or combined with a sudden increment of degradation because of an identical random shock. In sophisticated equipment like aircraft engine systems, the degradation path of performance parameters is characterized by multi‐stages when the product is more prone to fatigue or accelerated aging, as a consequence of experienced shocks. This article analyzes five random shock patterns that can change the slope of the degradation path and studies an example to explain the application of proposed reliability models as well as the sensitivity analysis of parameters.
Limonene: A scented and versatile tropospheric free radical deactivator
Authors: Francisco‐Márquez Misaela , Galano Annia 
Published: February 2023

AbstractThe reactions of limonene with various free radicals (•OCH3, •OBr, •SH, •OOH, and •OOCH3) were investigated along the 273.15–312.15 K temperature range. To that purpose the density functional theory was used, at the M06‐2X/6–311+g(d,p) level. Two reaction mechanisms, hydrogen atom transfer (HAT) and radical adduct formation (RAF) were considered. It was found that the relative reactivity of the studied radicals toward limonene is: •SH > •OBr > •OCH3 > •OOH > •OOCH3. HAT was identified as the dominant mechanism for •OOH and •OOCH3, while RAF contributes the most to the reactions involving •OCH3, •OBr, and •SH. The obtained Arrhenius expressions are: k(•OCH3) = 1.58 × 10−13 e−1.59/RT, k(•OBr) = 3.55 × 10−12 e+1.82/RT, k(•SH) = 3.30 × 10−11 e+0.79/RT, k(•OOH) = 1.33 × 10−15 e−5.99/RT, and k(•OOCH3) = 5.88 × 10−17 e−6.26/RT. According to them, the reactions of •OBr and •SH become slower as temperature rises from 273.15 to 312.15 K, while for the other radicals the reactions rate increases with temperature. The subsequent tropospheric fate of the most abundant •OBr adduct was also investigated in the same temperature range, considering O2 addition to this radical (step 2) and the reaction of the peroxyl radical yielded in this step 2 with NO. The latter is predicted to take place in two steps: the NO addition (3a) and the NO2 elimination (3b). The corresponding Arrhenius expression are k2 = 3.56 × 10−15 e+1.43/RT and k3b = 1.35 × 1014 e−31.65/RT. Step 3a was found to be barrierless. To our best knowledge, all the data provided here is reported for the first time. Thus, it would hopefully contribute to enhance the knowledge necessary for the full understanding (and accurate modeling) of the troposphere.
A Nature‐Inspired Separator with Water‐Confined and Kinetics‐Boosted Effects for Sustainable and High‐Utilization Zn Metal Batteries
Authors: Qin Hongyu , Chen Wenjian , Kuang Wei , Hu Nan , Zhang Xiaoyan , Weng Haofan , Tang Huan , Huang Dan , Xu Jing , He Huibing 
Published: February 2023

AbstractUncontrollable dendrite growth and sluggish ion‐transport kinetics are considered as the main obstacles for the further development of high‐performance aqueous zinc ion batteries (AZIBs). Here, a nature‐inspired separator (ZnHAP/BC) is developed to tackle these issues via the hybridization of the biomass‐derived bacterial cellulose (BC) network and nano‐hydroxyapatite particles (HAP). The as‐prepared ZnHAP/BC separator not only regulates the desolvation process of the hydrated Zn2+ ions (Zn(H2O)62+) by suppressing the water reactivity through the surface functional groups, alleviating the water‐induced side‐reactions, but also boosts the ion‐transport kinetics and homogenize the Zn2+ flux, resulting in a fast and uniform Zn deposition. Remarkably, the Zn|Zn symmetric cell with ZnHAP/BC separator harvests a long‐term stability over 1600 h at 1 mA cm−2, 1 mAh cm−2 and endures stable cycling over 1025 and 611 h even at a high depth of discharge (DOD) of 50% and 80%, respectively. The Zn|V2O5 full cell with a low negative/positive (N/P) capacity ratio of 2.7 achieves a superior capacity retention of 82% after 2500 cycles at 10 A g−1. Furthermore, the Zn/HAP separator can be totally degraded within 2 weeks. This work develops a novel nature‐derived separator and provides insights in constructing functional separators toward sustainable and advanced AZIBs.
Charge imbalance resolved Rényi negativity for free compact boson: Two disjoint interval case
Authors: Gaur Himanshu , Yajnik Urjit A. 
Published: February 2023

Abstract
In this paper, we study the symmetry decomposition of Rényi negativity into charge imbalance sectors for the 1+1 dimensional free compact boson field with a global U(1) symmetry in the ground state for the case of two disjoint intervals. We obtain multicharged and charged Rényi negativity moments by computing the four-point correlator of flux-generating vertex operators on the Riemann surface. We then obtain charge imbalance resolved Rényi negativity by taking the Fourier transform of the charged moments. Finally, we match our results against the tight-binding model as a numerical check.
Searching for a single photon from lightest neutralino decays in R-parity-violating supersymmetry at FASER
Authors: Dreiner Herbi K. , Köhler Dominik , Nangia Saurabh , Wang Zeren Simon 
Published: February 2023

Abstract
In this work, we propose a search for a single photon at FASER and FASER2, produced from decays of bino-like, sub-GeV lightest neutralinos in the theoretical framework of the R-parity-violating (RPV) Minimal Supersymmetric Standard Model (MSSM). We consider a list of representative benchmark scenarios with one or two non-vanishing RPV couplings. The photon has an energy 𝒪(0.1) − 𝒪(1) TeV. We find a sensitivity reach for RPV couplings beyond the current bounds by orders of magnitude at FASER and FASER2.
Axion-like particles as mediators for dark matter: beyond freeze-out
Authors: Bharucha A. , Brümmer F. , Desai N. , Mutzel S. 
Published: February 2023

AbstractWe consider an axion-like particle (ALP) coupled to Standard Model (SM) fermions as a mediator between the SM and a fermionic dark matter (DM) particle. We explore the case where the ALP-SM and/or the ALP-DM couplings are too small to allow for DM generation via standard freeze-out. DM is therefore thermally decoupled from the visible sector and must be generated through either freeze-in or decoupled freeze-out (DFO). In the DFO regime, we present an improved approach to obtain the relic density by solving a set of three stiff coupled Boltzmann equations, one of which describes the energy transfer from the SM to the dark sector. Having determined the region of parameter space where the correct relic density is obtained, we revisit experimental constraints from electron beam dump experiments, rareBandKdecays, exotic Higgs decays at the LHC, astrophysics, dark matter searches and cosmology. In particular, for our specific ALP scenario we (re) calculate and improve beam dump, flavour and supernova constraints. Throughout our calculation we implement state-of-the-art chiral perturbation theory results for the ALP partial decay width to hadrons. We find that while the DFO region, which predicts extremely small ALP-fermion couplings, can probably only be constrained by cosmological observables, the freeze-in region covers a wide area of parameter space that may be accessible to other more direct probes. Some of this parameter space is already excluded, but a significant part should be accessible to future collider experiments.
On supersymmetric multipole ratios
Authors: Ganchev Bogdan , Mayerson Daniel R. 
Published: February 2023

Abstract
Four-dimensional supersymmetric black holes are static and so have all vanishing multipoles (except the mass monopole). Nevertheless, it is possible to define finite multipole ratios for these black holes, by taking the ratio of (finite) multipoles of supersymmetric multicentered geometries and then taking the black hole scaling limit of the multipole ratios within these geometries. An alternative way to calculate these multipole ratios is to deform the supersymmetric black hole slightly into a non-extremal, rotating black hole, calculate the multipole ratios of this altered black hole, and then take the supersymmetric limit of the ratios. Bena and Mayerson observed that for a class of microstate geometries, these two a priori completely different methods give spectacular agreement for the resulting supersymmetric black hole multipole ratios. They conjectured that this agreement is due to the smallness of the entropy parameter for these black holes. We correct this conjecture and give strong evidence supporting a more refined conjecture, which is that the agreement of multipole ratios as calculated with these two different methods is due to both the microstate geometry and its corresponding black hole having a property we call “large dipole”, which can be interpreted as their center of mass being far away from its apparent center.
A Weak-Type Expression of the Orlicz Modular
Authors: Křepela Martin , Mihula Zdeněk , Soria Javier 
Published: February 2023

AbstractAn equivalent expression of Orlicz modulars in terms of measure of level sets of difference quotients is established. The result in a sense complements the famous Maz’ya–Shaposhnikova formula for the fractional Gagliardo–Slobodeckij seminorm and its recent extension to the setting of Orlicz functions.
Complications and revisions in anatomic and reverse short stem shoulder arthroplasty
Authors: Loew Markus , Schnetzke Marc , Kappes Sophia , Bruckner Thomas , Nolte Anna-Katharina 
Published: February 2023

Abstract
Introduction
One current trend in the field of shoulder arthroplasty is a design shift to shorter and metaphyseal fixed humeral stem components. The aim of this investigation is to analyze complications resulting in revision surgery after anatomic (ASA) and reverse (RSA) short stem arthroplasty. We hypothesize that complications are influenced by the type of prosthesis and indication for arthroplasty.

Materials and methods
A total of 279 short stem shoulder prostheses were implanted by the same surgeon (162 ASA; 117 RSA), and 223 of these prostheses were implanted as primary procedures; in 54 cases, arthroplasty was performed secondary to prior open surgery. Main indications were osteoarthritis (OA) (n = 134), cuff tear arthropathy (CTA) (n = 74) and posttraumatic deformities (PTr) (n = 59). Patients were evaluated at 6 weeks (follow-up 1; FU1), 2 years (FU2) and the time span of the last follow-up defined as FU3 with a minimum FU of 2 years. Complications were categorized into early complications (within FU1), intermediate complications (within FU2) and late complications (> 2 years; FU3).

Results
In total, 268 prostheses (96.1%) were available for FU1; 267 prostheses (95.7%) were available for FU2 and 218 prostheses (77.8%) were available for FU3. The average time for FU3 was 53.0 months (range 24–95). A complication leading to revision occurred in 21 prostheses (7.8%), 6 (3.7%) in the ASA group and 15 (12.7%) in the RSA group (p < 0.005). The most frequent cause for revision was infection (n = 9; 42.9%). After primary implantation, 3 complications (2.2%) occurred in the ASA and 10 complications (11.0%) in the RSA group (p < 0.005). The complication rate was 2.2% in patients with OA, 13.5% in CTA and 11.9% in PTr.

Conclusions
Primary reverse shoulder arthroplasty had a significantly higher rate of complications and revisions than primary and secondary anatomic shoulder arthroplasty, respectively. Therefore, indications for reverse shoulder arthroplasty should be critically questioned in each individual case.
Early treatment response as predictor of long-term outcome in a clinical cohort of children with ADHD
Authors: Houmann Tine Bodil , Kaalund-Brok Kristine , Clemmensen Lars , Petersen Morten Aagaard , Plessen Kerstin Jessica , Bilenberg Niels , Verhulst Frank , Jeppesen Pia ,   INDICES, Rasmussen Henrik Berg , Bjerre Ditte , Madsen Majbritt Busk , Ferrero Laura , Linnet Kristian , Thomsen Ragnar , Jürgens Gesche , Stage Claus , Stefansson Hreinn , Hankemeier Thomas , Kaddurah-Daouk Rima , Brunak Søren , Taboureau Olivier , Nzabonimpa Grace Shema , Houmann Tine , Jeppesen Pia , Kaalund-Brok Kristine , Hansen Peter Riis , Kristensen Karl Emil , Pagsberg Anne Katrine , Plessen Kerstin , Hansen Poul-Erik , Zhang Wei , Werge Thomas 
Published: February 2023

AbstractThis study investigates early onset of treatment response as predictor of symptomatic and functional outcome 3 years after initiation of methylphenidate (MPH) administration in a naturalistic, clinical cohort of children and adolescents with ADHD. Children were followed across an initial 12-week MPH treatment trial and after 3 years, with ratings of symptoms and impairment. Associations between a clinically significant MPH treatment response in week 3 (defined as ≥ 20% reduction in clinician-rated symptoms) and in week 12 (defined as ≥ 40% reduction), and 3-year outcome were tested in multivariate linear regression models, adjusting for sex, age, comorbidity, IQ, maternal education, parental psychiatric disorder, and baseline symptoms and function. We did not have information on treatment adherence or the nature of treatments beyond 12 weeks. 148 children, mean age 12.4 years (range 10–16 years), 77% males, participated in the follow-up. We found a significant decrease in symptom score from baseline [M = 41.9 (SD = 13.2)] to 3-year follow-up [M = 27.5 (SD = 12.7), p < 0.001, and in impairment score from baseline (M = 41.6 (SD = 19.4)] to 3-year follow-up [M = 35.6 (SD = 20.2), p = 0.005]. Treatment responses in week 3 and week 12 were significant predictors of the long-term outcome of symptoms, but not of impairment at 3-year follow-up, when adjusting for other well-known predictors. Early treatment response predicts long-term outcome over and above other well-known predictors. Clinicians should follow-up patients carefully, during the first months of treatment, and detect non-responders, since there might be a window of opportunity to alter the outcome, by changing the treatment strategy.Clinical trial registration: ClinicalTrials.gov, registration number NCT04366609, April 28, 2020 retrospectively registered.