bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Variable Frequency Drive System in Pumping Stations of Irrigation Networks Using INACSEM Model
Authors: Ostad‐Ali‐Askari Kaveh , Sadeghi Fatemeh , Vanani Hamid Raeisi , Monem Mohammad Javad , Kianmehr Peiman 
Published: January 2025

ABSTRACTLimited resources for the construction of new irrigation networks and low performance of most of them have led to more attention to evaluate and improve the performance of networks. The use of automated systems to improve performance and increase flexibility in irrigation networks is expanding. Regarding the variety of equipment, algorithms and applications of various automated systems in different parts of irrigation networks, it is necessary to develop performance evaluation models that include all aspects of automation. In this research, the irrigation networks automatic control system evaluation model (INACSEM) has been prepared using the classical evaluation method to assess automated control systems in irrigation networks. In this model, evaluation includes both technical and general approach. The technical point of view includes the types of equipment, software and automated control structures and their application in different stages of operation in different parts of the network and the general approach, which includes the general aspects of evaluation, mainly the managerial, social, economic and environmental point of views. The remote‐control system [by variable frequency drive (VFD)] installed in the pumping stations of Moghan plain was examined in order to show the application of the developed model. The results of performance evaluation of the automatic system show a performance of 82% with a validity of 74% in the pumping stations of Moghan plain. The results indicate the suitability of the model for evaluating automated systems in irrigation networks. Considering all aspects of automation, it also shows the problems of its components.
Internalized Transnegativity, Self‐Warmth, Self‐Coldness, and Eating Disorder Symptomatology Among Transgender and Nonbinary Adults
Authors: McArthur Sarah , McLaren Suzanne , Goldie Peter D. 
Published: January 2025

ABSTRACTEating disorders (EDs) are highly prevalent among transgender and nonbinary (TNB) adults, and internalized transnegativity is a key risk factor for ED symptomatology. Although extant literature has established that self‐compassion protects against EDs among the cisgender population, research among TNB adults is nascent. The current study sought to identify whether internalized transnegativity and components of self‐compassion (i.e., self‐warmth and self‐coldness) were independently associated with ED symptomatology, and whether the components of self‐compassion moderated the relation between internalized transnegativity and ED symptomatology. An international sample of 127 TNB adults aged between 18 and 69 years (M = 32.24, SD = 11.12) completed the Transgender Identity Survey, the Self‐Compassion Scale, and the Screen for Disordered Eating via an online survey. Simple linear regression models were run, followed by moderation analyses. Internalized transnegativity and self‐coldness were associated with ED symptomatology, but self‐warmth was not. Self‐warmth and self‐coldness did not moderate the relation between internalized transnegativity and ED symptomatology. The results highlight that self‐coldness and, to a lesser extent, internalized transnegativity account for a significant portion of the variance in ED symptomatology among TNB adults. Although these effect sizes were small, they have important clinical implications. Future research should take alternative analytical approaches to examine how self‐warmth, self‐coldness, and internalized transnegativity are related to ED symptomatology among TNB adults.
Extracellular RNA communication: A decade of NIH common fund support illuminates exRNA biology
Authors: Amolegbe Sara M. , Johnston Nicolas C. , Ambrosi Angela , Ganguly Aniruddha , Howcroft T. Kevin , Kuo Lillian S. , Labosky Patricia A. , Rudnicki Dobrila D. , Satterlee John S. , Tagle Danilo A. , Happel Christine 
Published: January 2025

AbstractThe discovery that extracellular RNAs (exRNA) can act as endocrine signalling molecules established a novel paradigm in intercellular communication. ExRNAs can be transported, both locally and systemically in virtually all body fluids. In association with an array of carrier vehicles of varying complexity, exRNA can alter target cell phenotype. This highlights the important role secreted exRNAs have in regulating human health and disease. The NIH Common Fund exRNA Communication program was established in 2012 to accelerate and catalyze progress in the exRNA biology field. The program addressed both exRNA and exRNA carriers, and served to generate foundational knowledge for the field from basic exRNA biology to future potential clinical applications as biomarkers and therapeutics. To address scientific challenges, the exRNA Communication program developed novel tools and technologies to isolate exRNA carriers and analyze their cargo. Here, we discuss the outcomes of the NIH Common Fund exRNA Communication program, as well as the evolution of exRNA as a scientific field through the analysis of scientific publications and NIH funding. ExRNA and associated carriers have potential clinical use as biomarkers, diagnostics, and therapeutics. Recent translational applications include exRNA‐related technologies repurposed as novel diagnostics in response to the COVID‐19 pandemic, the clinical use of extracellular vesicle‐based biomarker assays, and exRNA carriers as drug delivery platforms. This comprehensive landscape analysis illustrates how discoveries and innovations in exRNA biology are being translated both into the commercial market and the clinic. Analysis of program outcomes and NIH funding trends demonstrate the impact of this NIH Common Fund program.
Body Temperature Regulation in Domestic Dogs After Agility Trials: The Effects of Season, Training, Body Characteristics, Age, and Genetics
Authors: Russel William Andrew , Jiménez Ana Gabriela , Paul Kailey D. , Hoopes Barbara C. , Ay Ahmet 
Published: January 2025

ABSTRACTAn animal's body mass is said to be indirectly related to its rate of heat loss; that is, smaller animals with higher surface area to volume tend to lose heat faster than larger animals. Thus, thermoregulation should be related to body size, however, generalizable patterns are still unclear. Domestic dogs are a diverse species of endothermic mammals, including a 44‐fold difference in body size. Previous work in sedentary dogs has determined that body size and other morphological variables tend to predict the thermoregulation of exercising pet dogs. Here, we aimed to address three questions: (1) whether thermoregulatory differences in domestic dogs across seasons are dictated strictly by external environmental temperatures or if individual thermal acclimation is affected by seasonal temperature variation, even indoors; (2) whether athleticism (or training experience) affects or changes thermoregulation in dogs, as it does in humans; and (3) whether thermoregulation in domestic dogs has a genetic basis. We obtained tympanic membrane (Tear) temperatures and thermal images to measure the rate of temperature change in the eyes, mouth, and nose of athletic dogs following an indoor agility trial. Additionally, we used image analysis to determine body morphology differences. We found body mass to play a strong role in thermoregulation in winter trials (Tmouth p = 0.017, Tnose p = 0.052) but a less determinate role in summer trials. We found distinct differences in thermoregulation patterns between winter and summer. Particularly, coat morphology and length may play different roles in thermoregulation across seasons. Additionally, we found that rates of mouth temperature change differ by an interaction between environmental temperature and training experience (p = 0.044), suggesting seasonal thermoregulation patterns in dogs depend on relative athleticism. Lastly, we found important genetic predictors of temperature change rate, such as GORAB and IGF1, as well as others that exert influence over body size, mitochondrial function, or coat characteristics. These genetic markers indicate markers similar to our whole‐animal physiological results. Overall, our data suggest that domestic dogs demonstrate thermal acclimation across seasons, that athleticism changes thermoregulatory patterns in domestic dogs, and that body size‐related genes are associated with thermoregulation in dogs.
A retrospective comparative study of percutaneous transhepatic gallbladder drainage versus endoscopic gallbladder stenting on the clinical course of acute cholecystitis: A propensity score matching analysis using a nationwide inpatient database in Japan
Authors: Ebinuma Shota , Nagano Hiroyuki , Itoshima Hisashi , Kunisawa Susumu , Fushimi Kiyohide , Sugiura Ryo , Kakisaka Tatsuhiko , Taketomi Akinobu , Imanaka Yuichi 
Published: January 2025

AbstractBackgroundWe performed a retrospective comparative study to clarify the optimal gallbladder drainage method prior to elective cholecystectomy.MethodsWe collected data from the Diagnosis Procedure Combination database about cholecystitis patients who underwent gallbladder drainage prior to cholecystectomy in a subsequent hospitalization between April 2014 and March 2020. We divided the study population into two groups: an endoscopic gallbladder stenting (EGBS) group and a percutaneous transhepatic gallbladder drainage (PTGBD) group. We performed propensity score matching and compared surgical outcomes related to cholecystectomy.ResultsWe collected 6306 cases (PTGBD: 6112 cases; EGBS: 194 cases). In propensity score matching, we obtained 193 matched pairs from the study population. Long‐term postoperative antibiotics therapy (2 vs. 9; risk ratio 4.7 [95% CI: 1.1–30.9]) was more frequent in the EGBS group than the PTGBD group. There were no significant differences between the two groups for laparotomic cholecystectomy and postoperative bile duct drainage. For reoperation, postoperative abdominal drainage and postoperative blood transfusion, there were few outcome occurrences and effect measures were not obtained.ConclusionGallbladder drainage by EGBS may have more risk of surgical complications related to elective cholecystectomy than PTGBD. There are a few reports on this topic, so further research should be conducted.
Heads and Tails: Comparative Osteology of Nearctic Dipsadid Snakes
Authors: Murta‐Fonseca Roberta Azeredo , Fernandes Daniel Silva , Martins Angele 
Published: January 2025

ABSTRACTAlthough numerous studies have addressed some aspects of the cranial osteology of Nearctic dipsadid species, only the species within the genera Heterodon and Carphophis have a formal published description of their skull. Similarly, vertebral data on such species are extremely scarce, and most of the available literature is focused on fossils. Such group has a complex phylogenetic history, being recovered as monophyletic or nonmonophyletic depending on the approach. In this paper, we provide detailed and comparative descriptions of the osteology of dipsadid species distributed in the Nearctic region based on 69 specimens of dry material and high‐resolution computed tomography (CT) scans. Additionally, we explore the morphological variation of the skull and cervical vertebrae within the context of distinct phylogenetic hypotheses previously proposed. Only two suprageneric groups previously proposed shared exclusive morphological traits: (Carphophis amoenus + Contia tenuis), proposed by three studies, and (Diadophis punctatus (Ca. amoenus + Co. tenuis)), proposed by one study. Large and detailed studies on the skull, mandible, and vertebrae represent an important step toward the understanding of the evolution of species, especially when they also show intraspecific variation.
High‐Resolution Analysis of Severe Heat Wave Dynamics and Thermal Discomfort Across India
Authors: Lakshman Kesireddy , Nadimpalli Raghu , Srivastava Akhil , Osuri K. K. , Attada Raju , Parekh Anant 
Published: January 2025

ABSTRACTThe study explores variability and dynamical characteristics of heatwaves during March–June for 1990–2020 over India. Normalised Tmax anomaly is used to identify different heatwave spells in vulnerable regions of North‐central India (NCI) and Southeast coast of India (SECI) using India Meteorological Department (IMD, 1° × 1° resolution) observations, Indian Monsoon Data Assimilation and Analysis (IMDAA, 0.12° × 0.12°), and ECMWF Reanalysis v5 (ERA5, 0.25° × 0.25°). Results highlight that IMDAA exhibited a total 202 days (181 days) heatwaves duration in NCI (SECI) regions while ERA5 exhibited a total 132 days (89 days), respectively, compared with those of IMD (195 and 163 days). The primary heatwave periods for NCI (10 April to 20 June) and SECI region (1 May to 10 June) are well captured by IMDAA, unlike ERA5. The average length of the heatwave is 7.8, 7.5, and 7.76 days (8.15, 7.72, and 6.1 days) over NCI (SECI) in IMD, IMDAA, and ERA5, respectively. The high heat stress is more frequent in SECI than in the NCI region and is common during May–June (May only), as seen in IMDAA (ERA5). The middle to upper‐level anticyclone over NCI is stronger than SECI during heatwaves. Heat advection with stronger 850‐hPa north‐westerlies (~10 ms−1) abates sea breeze in the coastal region, aiding longer heatwaves in the SECI region. Ascending motion induced by surface heating is confined to the lower levels due to the subsidence by the upper‐level anomalous anticyclone, stagnating higher temperatures in the lower atmosphere, depicting a heat dome. The surface temperatures are slightly higher in NCI (31°C–39°C) than in SECI (30°C–37°C). However, the double moist heat dome in SECI has witnessed higher heat stress conditions than NCI. Higher relative humidity in the SECI region is contributed by maritime winds from the Bay of Bengal and Arabian Sea, soil moisture, and so forth. The study highlights the value of atmospheric moisture in differentiating the study regions for heat stress conditions.
Return to preinjury pivoting sports after anterior cruciate ligament reconstruction is different between males and females, as are the patient‐reported reasons
Authors: Ebert Jay R. , Kneebone Liza , Edwards Peter , Radic Ross , D'Alessandro Peter 
Published: January 2025

ABSTRACTPurposeTo investigate return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR), differences based on sex and concomitant meniscal repair, and identify reasons why patients do not RTS.MethodsOverall, 232 patients undergoing ACLR, with or without concomitant meniscal repair, that were actively participating in pivoting sports at the time of injury, were prospectively recruited. At 2 years, return to preinjury pivoting sport was investigated and, if they had returned, whether they felt their performance was at (or better) or below preinjury status. Specific reasons for not returning were identified. RTS rates and reasons for not returning were compared based on sex and meniscal repair.ResultsOverall, 140 patients (60.3%) had returned to their preinjury pivoting sport, of which 98 (70.0%) felt they were performing at (or beyond) preinjury status. While a significantly greater (p = 0.024) percentage of males (66.9%) versus females (52.4%) had returned to pivoting sports by 2 years, no differences (p = 0.708) were seen based on concomitant meniscal repair. Overall, 92 patients (39.7%) had not RTS, with primary reasons being loss of interest (21.7%), too busy due to their work and/or family environment (22.8%), or fear of reinjury or lacking confidence (17.4%). Other less‐reported reasons included ongoing knee issues (6.5%) or not feeling physically ready (5.4%).ConclusionsThis study outlined specific reasons why community‐level patients do not RTS, with RTS status (and reasons for not returning to preinjury pivoting sports) differing between males and females, with the latter returning at a significantly lower rate overall.Level of EvidenceLevel IV.
Exploring implementation of interventions to facilitate integration in fragmented healthcare systems
Authors: Bragdon Cassandra , Siden Rachel , Winget Marcy , Harris Sonia Rose , Carey Rebecca , Ko Justin , Vyas Alpa , Brown‐Johnson Cati 
Published: January 2025

AbstractIntroductionStanford Medicine is working to better coordinate care across the Stanford healthcare system, as well as improve patient and provider experiences in seeking and receiving care. This study aimed to explore the complexities of moving from a fragmented to an integrated academic healthcare system and to identify and explain factors (e.g., facilitators and barriers) of the implementation of three interventions meant to improve patient experience, reduce staff burden, and integrate health care systems across faculty and community settings.MethodsWe conducted qualitative semi‐structured interviews via Zoom with faculty and community physicians. Interviews were audio‐recorded, professionally transcribed, and analyzed using the Consolidated Framework for Implementation Research (CFIR) and open coding. Using consensus coding approaches, researchers met regularly to discuss themes and adaptations to CFIR.ResultsWe analyzed transcripts from interviews with physicians (n = 26). Factors impacting integration included the following: (1) physicians supported the interventions, promoting mission alignment; (2) physicians were motivated for change, reporting the existing system was intolerable; (3) physicians reported different priorities between clinics: faculty versus community and primary care versus specialty; (4) physicians prioritized interpersonal versus system solutions; (5) specialists were wary of unintended consequences of integration, specifically inappropriate bookings or patients being redirected to other clinics. Broadly speaking, facilitator factors 1–2 focused on the openness to, and tension for, change; and barrier factors 3–5 promoted or sustained variation across specialties and faculty/community clinics.ConclusionsOur results illustrate the challenges and opportunities of moving from a fragmented to an integrated healthcare system and emphasize the importance of building shared culture, collaboration, and coordinated actions across and within an integrated healthcare network.
U‐Shaped Association Between Dietary Copper Intake and New‐Onset Chronic Kidney Disease: A 30‐Year Follow‐Up Study From Young Adulthood to Midlife
Authors: Zhang Yiwei , Gan Xiaoqin , Xiang Hao , Zhang Yanjun , Yang Sisi , Ye Ziliang , Huang Yu , Wu Yiting , Mai Jinsheng , Jiang Jianping , Qin Xianhui , Zhang Yuanyuan 
Published: January 2025

ABSTRACTScope: The relationship of dietary copper intake with new‐onset chronic kidney disease (CKD) remained unclear. We aimed to examine the association of dietary copper intake with new‐onset CKD in a 30‐year follow‐up study from young adulthood to midlife. Methods and results: A total of 4038 U.S. adults aged 18–30 years and without reduced estimated glomerular filtration rate (eGFR) from the Coronary Artery Risk Development in Young Adults (CARDIA) study was included. During a 30‐year follow‐up, 642 (15.9%) participants developed new‐onset CKD. Overall, there was a U‐shaped relationship between dietary copper intake and new‐onset CKD (p for nonlinearity = 0.034). When copper intake was assessed as quartiles, compared with those in the second quartile (2.03–<2.46 mg/day), the adjusted hazard ratios (HRs) (95% confidence interval [CI]) for new‐onset CKD were 1.29 (1.05, 1.66), 1.29 (1.02, 1.64), and 1.49 (1.16, 1.91) for participants in the first (<2.03 mg/day), third (2.46–<3.11 mg/day), and fourth (≥3.11 mg/day) quartiles, respectively. Similar U‐shaped associations were observed for new‐onset eGFR decline and albuminuria. Conclusions: There was a U‐shaped relationship of dietary total copper intake with new‐onset CKD, with the lowest risk at a dietary copper intake of 2.03–<2.46 mg/day. Emphasizing the importance of maintaining optimal copper intake levels for the primary prevention of CKD.
An Exact and Approximate Schur Complement Method for Time‐Harmonic Optimal Control Problems
Authors: Axelsson Owe , Lukáš Dalibor , Neytcheva Maya 
Published: January 2025

ABSTRACTTime‐harmonic control problems, constrained by a linear differential equation, can be solved efficiently by utilizing a Fourier time series expansion in the angular frequency variable. Then the optimal solution consists of a series of complex variable space discretization equations, which are uncoupled with respect to the different frequencies. Hence, it suffices to consider a single equation with the angular frequency as a parameter. We consider here methods to solve the so‐arising linear system of equations and describe, analyze and test the performance of two novel approaches based on its exact and approximate Schur complement. The performance of the methods is tested and compared with another existing method.
Genome‐Wide Analysis of the APETALA2/Ethylene‐Responsive Factor Gene Family in Carthamus tinctorius L.
Authors: Tan Zheng‐Wei , Lu Dan‐Dan , Yu Yong‐Liang , Li Lei , Xu Lan‐Jie , Dong Wei , Li Chun‐Ming , Yang Qing , Liang Hui‐Zhen 
Published: January 2025

ABSTRACTThe APETALA2/ethylene‐responsive factor (AP2/ERF) superfamily represents a class of transcription factors involved in plant growth, development, and stress responses. Carthamus tinctorius L., also known as safflower, is an important plant whose flowers contain carthamin, an expensive aromatic pigment with various medicinal and flavoring properties. This study aimed to elucidate the roles of these transcription factors in plant growth, metabolic regulation, and environmental adaptation in safflower, providing foundational information and theoretical support for genetic improvement and stress resilience research in this crop. In this study, we identified and characterized the AP2/ERF family genes in safflower through a comprehensive genomic analysis. A total of 127 AP2/ERF genes were identified and clustered into seven groups and 14 subgroups based on phylogenetic analysis. Multiple sequence alignment revealed that the basic region and two helical structures were highly conserved in most AP2/ERF proteins. Cis‐acting elements in the promoters of the AP2/ERF genes were analyzed, and a degree of safflower specificity was observed among different safflower species. Tissue‐specific expression analysis showed that 23, 21, 15, and 9 genes were most abundantly expressed in the roots, leaves, flowers, and buds, respectively, while only eight genes were highly expressed in all tissues examined. These results indicate that the AP2/ERF family genes in safflower are diverse and complex, with distinct expression patterns for different genes in different safflower species. The findings provide important fundamental data for in‐depth studies of the growth, development, and stress response mechanisms in safflower.