bluuebunny/crossref_metadata_2025_split huggingface dataset:
Site-specific performance of 68Ga-DOTATATE PET/CT in detecting tumors with ectopic adrenocorticotropic hormone secretion
Authors: Wang Junhu , Luan Zhonghua , Li Ting , Guan Xiaodong 
Published: June 2023

ObjectiveThe aim of this study was to assess the detection ability of 68Ga-DOTATATE in pulmonary versus extrapulmonary tumors with ectopic adrenocorticotropic hormone secretion (EAS).MethodsImages of 68Ga-DOTATATE PET/CT from 74 patients with suspected EAS were retrospectively reviewed. EAS tumors were confirmed in 39 patients through surgical resection or biopsy. Image findings were compared with the histopathological results.ResultsEAS tumors were pathologically confirmed via surgery or biopsy in 39 patients. Among those 39 patients, 25 were with pulmonary neuroendocrine tumors (NETs), and the remaining 14 were with extrapulmonary NETs. 68Ga-DOTATATE PET/CT correctly identified the tumor in 26 patients, rendering an overall detection rate of 66.7%. On a site-based analysis, 68Ga-DOTATATE PET/CT correctly identified the EAS tumor in 13 of 25 patients with pulmonary NETs, yielding a detection rate of 52%; for the 14 patients with extrapulmonary NETs, 68Ga-DOTATATE PET/CT correctly identified the EAS tumor in 13, yielding a detection rate of 92.9%. The detection rate of 68Ga-DOTATATE was significantly higher in extrapulmonary NETs than in pulmonary NETs (92.9%% vs. 52%, P = 0.013). For the 13 patients with positive pulmonary NETs, the tumor SUVmax ranged from 1.1 to 7.4 with an average SUVmax of 3.1 ± 2.1. For the 13 patients with positive extrapulmonary NETs, the tumor SUVmax ranged from 2.7 to 21.8 with an average SUVmax of 9.9 ± 6.3. The tumor SUVmax was significantly higher in extrapulmonary tumors than pulmonary tumors (P = 0.015). The tumor size was smaller in pulmonary tumors than in extrapulmonary tumors, while the difference was not significant (P = 0.516).Conclusion68Ga-DOTATATE showed site-specific difference in detecting tumors with EAS secretion. Specifically, 68Ga-DOTATATE performed better in the extrapulmonary EAS tumors than in pulmonary ones with both higher detection rate and uptake. Combination of anatomic imaging techniques are necessary for the correct diagnosis of pulmonary EAS tumors.
Joint effect of overweight/obesity and tobacco exposure on hypertension in children aged 6–17 years: a cross-sectional study
Authors: Gu Huan , Hao Long , Li Mingxi , Li Ji 
Published: June 2023

AimTo assess the individual effects of overweight/obesity and tobacco exposure, and their combined effects on hypertension in children.MethodsThis cross-sectional study included 6,339 children aged 6–17 years from National Health and Nutrition Examination Surveys 1999–2018. Participants’ height, weight and blood pressure (BP) were measured by trained technicians. Hypertension was defined as: mean systolic BP (SBP) and/or diastolic BP (DBP) ≥ 90th percentile for sex, age, and height (for children aged 1–13 years), and SBP ≥120 mmHg and/or a DBP ≥80 mmHg (for adolescents aged 13–17 years); or self-reported having been diagnosed with hypertension or taking antihypertensive medication. Gender- and age-specific body mass index (BMI) cut-points were used to define overweight/obesity: “overweight” was defined as a BMI &gt; 1 standard deviation (SD); “obesity” was defined as BMI &gt; 2SD; and “thinness” was defined as BMI &lt; −2SD. Tobacco exposure was defined as having serum cotinine levels &gt;0.05 µg/L or reporting the presence of at least one smoker in the household. Weighted univariate and multivariate logistic regression models were used to assess overweight/obesity and tobacco exposure with the odds of hypertension, and the combined effects of overweight/ obesity and tobacco exposure on hypertension, followed by strata-specific analyses. Odds ratios (OR) with 95% confidence intervals (CI) were calculated.ResultsThe prevalence of overweight/obesity and tobacco exposure was significantly higher in the hypertension group than in the non-hypertension group. Overweight/obesity (OR = 1.67, 95%CI: 1.26–2.21/ OR = 2.38, 95%CI: 1.67–3.39) and tobacco exposure (OR = 1.58, 95%CI: 1.16–2.14) were associated with a higher odd of hypertension in children, respectively. Additionally, we also observed the combined effect between overweight (OR = 3.05, 95%CI: 1.96–4.75)/obesity (OR = 3.68, 95%CI: 2.24–6.03) and tobacco exposure were related to hypertension odds in children, with a significant effect in different populations.ConclusionThere may exist joint effect of overweight/obesity and tobacco exposure on the odds of hypertension in American children. These findings offer an insight that early weight control and reduction of tobacco exposure may be important to reduce odds of hypertension in children.
Cost-effectiveness of empagliflozin for the treatment of heart failure: a systematic review
Authors: Liu Jinyu , Liu Dong , Gong Xuepeng , Wei Anhua , You Ruxu 
Published: June 2023

Objective: This study aims to synthesize evidence on the cost-effectiveness of empagliflozin for heart failure (HF).Methods: MEDLINE, Embase, the Cochrane Library, EconLit, CNKI, Wanfang Data and Chongqing VIP were searched to identify original articles on cost-effectiveness of empagliflozin for HF, and literature surveillance ended on 20 November 2022. The reporting quality of the included articles was determined using the Consolidated Health Economic Evaluation Reporting Standards statement.Results: Of 97 articles identified, 11 studies published from 2020 to 2022 met the inclusion criteria, and the overall quality was accepted. The studies were conducted in 8 countries (China, Japan, Korea, Singapore, Thailand, Australia, United States, and United Kingdom). This body of evidence suggested that add-on empagliflozin was cost effective for HF with reduced ejection fraction (HFrEF) patients compared to standard of care alone in all the related studies including China, Japan, Korea, Singapore, Thailand, and Australia. For HF with preserved ejection fraction (HFpEF) patients, add-on empagliflozin was cost effective in China and Australia, but not in United States and Thailand. For HF with diabetes, add-on empagliflozin was cost effective in United Kingdom. Moreover, the incremental cost-effectiveness ratios (ICER) were lower for patients with diabetes than without in subgroup analysis. In the uncertainty analysis of all included studies, the ICERs were most sensitive to the cost of empagliflozin and cardiovascular mortality, followed by the cost of the standard treatment, hazard ratio of HF hospitalization.Conclusion: add-on empagliflozin for HFrEF might be cost-effective or dominant compared with standard of care alone. However, for HFpEF patients, add-on empagliflozin might be cost-effective in China and Australian, but not cost-effective in United States and Thailand.
Impact of deeper groundwater depth on vegetation and soil in semi-arid region of eastern China
Authors: Zhao Siteng , Zhao Xueyong , Li Yulin , Chen Xueping , Li Chengyi , Fang Hong , Li Wenshuang , Guo Wei 
Published: June 2023

IntroductionUnderstanding the impact of deep groundwater depth on vegetation communities and soil in sand dunes with different underground water tables is essential for ecological restoration and the conservation of groundwater. Furthermore, this understanding is critical for determining the threshold value of groundwater depth that ensures the survival of vegetation.MethodThis paper was conducted in a semi-arid region in eastern China, and the effects of deep groundwater depth (6.25 m, 10.61 m, and 15.26 m) on vegetation communities and soil properties (0–200 cm) across three dune types (mobile, semi-fixed, and fixed dunes) were evaluated in a sand ecosystem in the Horqin Sandy Land.ResultsFor vegetation community, variations in the same species are more significant at different groundwater depths. For soil properties, groundwater depth negatively influences soil moisture, total carbon, total nitrogen, available nitrogen, available phosphorus concentrations, and soil pH. Besides, groundwater depth also significantly affected organic carbon and available potassium concentrations. In addition, herb species were mainly distributed in areas with lower groundwater depth, yet arbor and shrub species were sparsely distributed in places with deeper groundwater depth.DiscussionAs arbor and shrub species are key drivers of ecosystem sustainability, the adaptation of these dominant species to increasing groundwater depth may alleviate the negative effects of increasing groundwater depth; however, restrictions on this adaptation were exceeded at deeper groundwater depth.
Pathways to the therapist paragon: a decolonial grounded theory
Authors: Bergkamp Jude , O’Leary Sloan Maeve , Krizizke Jack , Lash Malea , Trantel Noah , Vaught Jason , Fulmer Tessa , Waite Ilana , Martin Abigail M. , Scheiderer Cynthia , Olson Lindsay 
Published: June 2023

IntroductionWhile many professional associations within clinical and counseling psychology have made an aspirational call for clinician awareness of social position, there is a lack of research into how socially-conferred privilege impacts psychotherapy. Specifically of interest is the differences in race and gender within the therapeutic dyad, in which there is a BIPOC (Black, Indigenous, and Persons of Color)/white1 or male/female-identified dynamic.MethodThe authors utilized a Grounded Theory approach to analyze qualitative interviews with practicing psychologists to construct a process model regarding how socially-conferred privileged identity domains impact the therapeutic relationship and the participants’ professionalization process.ResultsThe analysis identified the core conceptual theme of the Therapist Paragon, representing an idealized version of what a perfect therapist should be. This replicated the foundational figures of our field - primarily older, white men. The process model consisted of two distinct pathways toward the Therapist Paragon, one for BIPOC psychologists and one for white psychologists. The female BIPOC pathway consisted of imposter syndrome, persistent feelings of inadequacy, and tendencies to over-credential their professional identity to seek credibility in the eyes of clients and colleagues. The white pathway consisted of down-playing whiteness and attempting to initially modify behavior toward client cultural norms.DiscussionThe results point to a distinct professionalization and practice process for BIPOC psychologists compared to white counterparts. This dynamic may have implications beyond increasing support for BIPOC clinicians specifically, but instead indicate a lack of acknowledgement of the psychological impact of socially-conferred privilege in the psychotherapy enterprise overall. Recommendations are offered for revisions to training models, continuing education, and supervision/consultation.
Deep brain stimulation programming for intractable obsessive–compulsive disorder using a long pulse width
Authors: Beydler Emily , Katzell Lauren , Putinta Kevin , Holbert Richard , Carr Brent 
Published: June 2023

IntroductionAround 25% of patients with obsessive–compulsive disorder (OCD) do not respond to medication or psychotherapy, producing significant impairment and treatment challenges. Deep Brain Stimulation (DBS) has been shown in multiple blinded trials to be a safe and durable emerging option for treatment-refractory OCD. Intraoperative device interrogation offers a theoretical anchor for starting outpatient DBS programming; however, no definitive post-operative programming algorithm for psychiatrists exists currently.CaseHere we present a 58-year-old female with childhood-onset, severe, intractable OCD with multiple failed trials of psychotherapy, medication, and electroconvulsive therapy. After interdisciplinary evaluation, she underwent bilateral electrode implantation targeting the anterior limb of the internal capsule, nucleus accumbens (ALIC/NAc). Intraoperative interrogation afforded sparse information about a preferred lead contact or current density target. Subsequent outpatient interrogation consisted of systematic and independent mapping using monopolar cathodic stimulation with constant current. Modulating bipolar and triple monopolar configurations, amplitude, and pulse width all failed to induce observable effects. Given negligible interrogation feedback, we created an electrical field through the ALIC bilaterally, using the three most ventral contacts to create triple monopoles, with a long pulse width and moderate amperage.ConclusionThree months post-programming, the patient reported significant improvement in OCD symptoms, particularly checking behaviors, with response sustained over the next several months. As with our case, the majority of DBS lead contacts do not induce affective or physiological markers in patients, complicating programming optimization. Here, we discuss an approach to titrating various stimulation parameters and purported mechanisms of physiological markers in DBS for OCD.
Newton's method and regularly smooth operators
Authors: Argyros Ioannis K. 
Published: June 2023

A semilocal convergence analysis for Newton's method in a Banach space setting is provided in this study. Using a combination of regularly smooth and center regularly smooth conditions on the operator involved, we obtain more precise majorizing sequences than in [7]. It then follows that under the same computational cost and the same or weaker hypotheses than in [7] the following benefits are obtained: larger convergence domain; finer estimates on the distances involved, and an at least as precise information on the location of the solution of the corresponding equation. Numerical examples are given to further validate the results obtained in this study.
Unpredictable nightmare in thyroid surgery: Incidental Parathyroidectomy
Authors: TURGUT Hamdi Taner , ÇİFTÇİ Ali , YAZICIOGLU Murat Burç 
Published: June 2023

Background: Incidental removal of the parathyroid gland is an unwanted minor complication of thyroidectomy and would occur even in experienced centers. The purpose of this study was to evaluate our clinic’s outcomes, incidence, and risk factors for incidental parathyroidectomy.
Methods: A total of 627 patients with an average age of 50.74±12.68 years were included in the study. Seventy-eight point nine percent of the patients had bilateral total thyroidectomy, 11.2% had a total lobectomy with isthmectomy, 4.8% had completed thyroidectomy, 4% had bilateral total thyroidectomy with bilateral central dissection and 1.1% had bilateral subtotal thyroidectomy. Incidental parathyroidectomy was observed in 6.4% (n=40) of all patients.
Results: There was a significant correlation between incidental parathyroidectomy and bilateral total thyroidectomy and bilateral central neck dissection. There were no statistically significant differences between the incidental and nonincidental parathyroidectomy group with respect to age and gender. While the preoperative diagnosis of hyperthyroidism (20.6% vs 7.5%) was significantly higher in the non-incidental parathyroidectomy group than in the incidental parathyroidectomy group, and the diagnosis of malignancy was significantly higher in the incidental parathyroidectomy group (32.5% vs. 11.6%, p=0.001). Regarding parathyroid localization, our incidental parathyroidectomy rate was higher in intrathyroidal localized cases. Postoperative transient hypocalcemia (62.5%) was higher in the incidental parathyroidectomy group than in the non-incidental parathyroidectomy group (34.4%, p
Los Orígenes de Propuesta Republicana (PRO) en Santa Fe (2009-2015): actores y redes políticas
Authors: Ramos Hugo 
Published: June 2023

Diversos trabajos analizan la emergencia del PRO en Ciudad de Buenos Aires (CABA) y su posterior crecimiento electoral hasta lograr la victoria en las elecciones presidenciales del año 2015 (Bellotti, Morressi y Vommaro, 2014; Vommaro y Morressi, 2015). Sin embargo, son escasos los estudios que den cuenta de cómo se conformó el partido en las distintas provincias de Argentina antes de su victoria nacional.
En este trabajo indagamos los orígenes y expansión del PRO en Santa Fe, distrito donde el partido estuvo muy cerca de ganar las elecciones a Gobernador en dos oportunidades (2011 y 2015). Desde una perspectiva anclada en la sociología política damos cuenta de los actores que intervinieron en su conformación y analizamos si sus orígenes y procedencia son similares a los observados para el caso de la Ciudad de Buenos Aires. El trabajo utiliza una metodología cualitativa y se basa en el análisis de noticias periodísticas obtenidas de medios gráficos de la provincia, especialmente de los diarios El Litoral (Santa Fe), La Capital (Rosario) y La Política On-line. Se estudia el período 2009-2015, identificado como coyuntura clave para la emergencia y consolidación del PRO en Santa Fe
The sacred and profane pada wisata religi kyai haji umar payaman kabupaten magelang
Authors: Zakaria Alif Muhammad , Moh. Mufid  
Published: June 2023

The sacred and the profane dinilai memiliki sisi yang berbeda, namun realitas secara ilmiah menjumpai bahwa dua hal tersebut merupakan dua sisi dalam satu mata uang yang sama. Penelitian dilakukan dengan pendekatan fenomenologis ini menjumpai bahwa peziarah yang datang dari berbagai daerah juga melakukan kegiatan yang sakral dengan berziarah sekaligus profane yang diperlihatkan melalui kegiatan berfoto selfie di dalam masjid, cara berpakaian dengan corak barat memperlihatkan bahwa western globalization telah masuk ke ranah masyarakat agama karena peranan teknologi internet dan media sosial, latar belakang KH Umar yang meninggalkan duniawi atau low profile berlainan dengan peziarah yang datang dengan sisi materialisnya. Hal tersebut menujukkan bahwa konsep yang sakral pada peziarah yang datang tersebut merupakan sakral yang semu. Kemudian adanya wisata religi memberikan ruang bagi pelaku usaha dan meningkatkan kesejahteraan ekonomi masyarakat sekitar.
Kata Kunci: Sakral, Profan, Wisata, Religi
Colchicine Effect on C-Reactive Protein Levels in Patients with Coronary Heart Disease after Myocardial Revascularization
Authors: Агабабян И.Р. , Кобилова Н.А. 
Published: June 2023

Цель. Изучить влияние колхицина на уровень С-реактивного белка у пациентов, перенесших чрескожное коронарное вмешательство (ЧКВ). Материалы и методы. Нами был проведен анализ пациентов с ишемической болезнью сердца, перенесших инфаркт миокарда, подвергшихся ЧКВ, с 1 августа по 1 ноябрь 2022 г., по данным Самаркандского областного регионарного филиала Республиканского специализированного научно-практического медицинского центра кардиологии. Всего было проанализировано 52 пациента, которым была проведена реваскуляризация миокарда. Результаты. У всех пациентов обеих групп, прошедших ЧКВ, был изначально повышен СРБ в среднем до 57,92±1,83 мг/л в первой группе, которая получала колхицин в дозе 0,5 мг в сутки, и 52,48±1,92 мг/л во второй группе, которая не получала колхицин. Через 3 месяца терапии у пациентов после ЧКВ на фоне приема колхицина С-реактивный белок снизился до 16,85±0,89 мг/л, в то время как во второй группе тоже уменьшился, но незначительно – 46,6±1,81 мг/л. Заключение. Применение колхицина в дозе 0,5 мг в сутки в течение 3 месяцев после ЧКВ значительно снизило уровень С-реактивного белка, а в группе без колхицина СРБ практически остался на тех же позициях.
Purpose. To study colchicine effect on C-reactive protein level in patients who underwent percutaneous coronary intervention (PCI). Materials and methods. We performed an analysis of patients with coronary heart disease who underwent PCI from August 1 to November 1, 2022, according to the data of the Samarkand regional branch of the Republican Specialized Scientific and Practical Medical Center for Cardiology. A total of 52 patients who underwent myocardial revascularization were analyzed. Results. All patients in both groups who underwent PCI had initially elevated CRP: to an average of 57.92±1.83 mg/L in group 1, receiving colchicine 0.5 mg per day, and 52.48±1.92 mg/L in group 2, which did not receive colchicine. After 3 months of therapy, C-reactive protein significantly decreased to 16.85±0.89 mg/L in patients after PCI against colchicine administration, while it also decreased, but insignificantly, to 46.6±1.81 mg/L, in patients of group 2. Conclusion. The use of colchicine at 0.5 mg per day for 3 months after PCI significantly reduced C-reactive protein levels, while in the group without colchicine CRP remained practically at the same level.
Postnatal Ontogenesis of Torsion Mechanisms of Child Heart in Prematurity: A Literature Review
Authors: Павлюкова Е.Н. , Колосова М.В. , Неклюдова Г.В. , Карпов Р.С. 
Published: June 2023

Высокие риски неблагоприятных событий со стороны сердечно-сосудистой системы в группе взрослых, рожденных недоношенными, требуют усиленного изучения вопросов физиологии и патофизиологии детского сердца при наличии информации о преждевременных родах в анамнезе, являющихся по современным представлениям хроническим состоянием. Истоки заболеваний сердца и сосудов во взрослом возрасте берут начало в патологии антенатального и раннего неонатального периодов развития и определяют в известной степени качество жизни взрослых пациентов в отдаленные временные промежутки. Использование современных неинвазивных ультразвуковых технологий исследования сердечно-сосудистой системы у детей, рожденных недоношенными с низкой, очень низкой и экстремально низкой массой тела, позволило получить новые данные фундаментального характера, а также существенно расширить традиционные представления о природе торсионных механизмов и вкладе потокогенной составляющей в процессы постнатального онтогенеза. Развитие различных моделей контрактильно-ротационных процессов и формирование нескольких вариантов вихревых диастолических потоков левого желудочка у детей в возрасте от одного года до пяти лет, рожденных недоношенными, является неотъемлемой частью процесса постнатального онтогенеза детского сердца при условии наличия фактора преждевременных родов в анамнезе.
High risks of adverse cardiovascular events in the group of adults born prematurely require an intensified study of the physiology and pathophysiology of the child heart given the history of preterm birth, which is considered as chronic condition under modern concepts. The origins of heart and vascular disease in adulthood originate in the pathology of antenatal and early neonatal periods, determining to a certain extent the quality of life of adult patients in remote time intervals. The use of modern non-invasive ultrasound technologies for studying the cardiovascular system in children born prematurely with low, very low and extremely low body weight allowed to obtain new fundamental data as well as to expand significantly conventional conceptions of the nature of torsion mechanisms and the contribution of the flow-generating component in postnatal ontogenesis. The development of various models of contractile-rotational processes and the formation of several variants of left ventricular vortex diastolic flows in preterm-born children aged one to five years is an integral part of the process of postnatal ontogenesis of the child heart given a history of preterm birth.
Urigoitiko hiztegitxoari buruz
Authors: Gonzalez Casado Asier 
Published: June 2023

Artikulu honetan Orozkon (Bizkaia) topatutako hitz zerrenda eskuizkribatu baten berri ematen dut. Orainokoan hiztegi hau ez da ezeingo ikerketa akademikotan deskribatu edo aipatu. Liburuxka Urigoiti auzoan agertu zen, baserri baten berriztapen lanetan. Egile edo data agerikorik gabe egon arren, behin-behineko azterketa baten ostean esan dezaket XIX. mendekoa dela eta inguru hartan (Orozko-Aiaraldean) idatzi zela. Ikerketa honen helburua da obratxoaren ezaugarri fisiko eta lexikografikoez aritzea, hiztegiaren edizio kritiko bat prestatzeko bidean. Hiztegia osatzeko baliatu ziren balizko iturriak, idatzizkoak zein ahozkoak, eta hiztegigilearen profila eta motibazioa ere hizpide ditut.