bluuebunny/crossref_metadata_2025_split huggingface dataset:
Demographically adjusted Rey–Osterrieth Complex Figure Test norms in a Swedish and Norwegian cohort aged 49–77 years and comparison with North American norms
Authors: Öhman Fredrik , Eckerström Marie , Hessen Erik , Espenes Jacob , Eliassen Ingvild V. , Lorentzen Ingrid M. , Stålhammar Jacob , Kettunen Petronella , Schöll Michael , Fladby Tormod , Wallin Anders , Kirsebom Bjørn‐Eivind 
Published: September 2023

IntroductionThe Rey–Osterrieth Complex Figure Test (RCFT) is one of the most commonly used neuropsychological tests in Sweden and Norway. However, no publications provide normative data for this population. The objective of this study was to present demographically adjusted norms for a Swedish and Norwegian population and to evaluate these in an independent comparison group.MethodsThe RCFT was administrated to 344 healthy controls recruited from the Swedish Gothenburg MCI study, the Norwegian Dementia Disease Initiation study, and the Swedish Cardiopulmonary Bioimage Study. Age ranged from 49 to 77 years (mean = 62.4 years, SD = 5.0 years), and education ranged from 6 to 24 years (mean = 13.3 years, SD = 3.0 years). Using a regression‐based procedure, we investigated the effects of age, sex, and years of education on test performance. We compared and evaluated our Swedish and Norwegian norms with North American norms in an independent comparison group of 145 individuals.ResultsIn healthy controls, age and education were associated with performance on the RCFT. When comparing normative RCFT performance in an independent comparison group, North American norms generally overestimated immediate and delayed recall performance. In contrast, our Swedish and Norwegian norms appear to better take into account factors of age and education.ConclusionsWe presented demographically adjusted norms for the RCFT in a Swedish and Norwegian sample. This is the first normative study of the RCFT that presents normative data for this population. In addition, we showed that North American norms might produce inaccurate normative estimations in an independent comparison group.
The use of a “horizontal centrifugation protocol” to prepare autologous platelet‐rich fibrin membranes for corneal reconstruction surgery in dogs with complicated corneal ulcerations: A case series
Authors: Baadsgaard Bruun Louise , Waskiw Hardon Tommy A. , Havnsøe Krogh Anne K. , Qvortup Klaus , Heegaard Steffen , Thuri Kristensen Annemarie , Henriksen Michala de Linde 
Published: September 2023

AbstractObjectiveThe purpose of this case series was to describe the effect of autologous PRF membrane for corneal reconstruction surgery in dogs. PRF membranes made from two healthy dogs unrelated to the current case series were used for PRF histologic analyses.AnimalsSeven dogs with complicated corneal ulcerations.ProcedureA complete ophthalmic examination, hematology, and fibrinogen analysis were performed pre‐surgery. A PRF clot was made from autologous blood in a serum tube after centrifugation in a horizontal Bio‐PRF® Centrifuge at 700 × g for 8 min. The PRF clot was processed in a PRF‐Box® into a PRF membrane. The PRF membrane was sutured to the corneal ulcer bed. Each dog had a follow‐up at days 5–7, 12–14, and 30–40 post‐surgery. A final long‐term follow‐up was performed as well.ResultsA positive outcome with healing and a “good” quality PRF membrane was seen in six out of seven dogs. One dog had a fibrinogen level below normal range and the PRF membrane was of “poor” quality. This dog developed a descemetocele 13 days post‐surgery and needed rescue surgery. Mean healing time for all dogs was 9 ± 5.5 days. Minimal scarring, corneal pigmentation, and vascularization were observed at the final long‐term follow‐up 288 ± 44 days post‐surgery.ConclusionPRF membrane was successful as graft material for corneal ulceration reconstruction surgery. Low fibrinogen appeared to have negative effect on the quality of the PRF membrane, showing the importance for the surgeon to evaluate the quality of the PRF membrane prior to surgery.
Coaxial Nozzle-Assisted Embedded 3D Printing of Single-Layered Channels Within a Yield-Stress Matrix Bath
Authors: Raymond Lily , Hua Weijian , Valentin Naima , Coulter Ryan , Bandala Erick , Leong Kaitlin , Okaikoi Jada , Jin Yifei 
Published: September 2023

Abstract
Creating multilayered channels for mimicking human blood vessels in thick tissues is the main challenge to overcome in organ biofabrication. Current three-dimensional (3D) printing strategies cannot effectively manufacture hollow channels with multiple layers. This study aims to propose a coaxial nozzle-assisted embedded 3D printing method in which core–shell filaments can be formed in a yield-stress matrix bath by extruding different ink materials through the corresponding channels. The materials selected for the core ink, shell ink, and matrix bath are Pluronic F127 (F127) and calcium chloride (CaCl2), sodium alginate (NaAlg), and poly(ethylene glycol) diacrylate (PEGDA) and nanoclay, respectively. After crosslinking the matrix bath and shell, the core layer made from the sacrificial ink (F127) is removed to generate a single-layered, hollow channel. In this work, the effects of ink material properties and operating conditions on core–shell filament formation have been systematically studied. The rheological and mechanical properties of the yield-stress matrix bath have been characterized as well. A thick tissue-like structure with embedded single-layered, hollow channels has been successfully printed for demonstration. Since it is feasible to design coaxial nozzles with a core–shell–shell architecture, the proposed method is technically extendable to create double-layered channels within a cellular tissue construct, accurately mimicking human blood vascular networks in thick tissues in the future.
Fifty-Five Prompt Questions for Identifying Social Impacts of Engineered Products
Authors: Mattson Christopher A. , Geilman Thomas B. , Cook-Wright Joshua F. , Mabey Christopher S. , Dahlin Eric , Salmon John L. 
Published: September 2023

Abstract
This article introduces 55 prompt questions that can be used by design teams to consider the social impacts of the engineered products they develop. These 55 questions were developed by a team of engineers and social scientists to help design teams consider the wide range of social impacts that can result from their design decisions. After their development, these 55 questions were tested in a controlled experiment involving 12 design teams. Given a 1-h period of time, 6 control teams were asked to identify many social impacts within each of the 11 social impact categories identified by Rainock et al. (2018, The Social Impacts of Products: A Review, Impact Assess. Project Appraisal, 36, pp. 230241), while 6 treatment groups were asked to do the same while using the 55 questions as prompts to the ideation session. Considering all 1079 social impacts identified by the teams combined and using 99% confidence intervals, the analysis of the data shows that the 55 questions cause teams to more evenly identify high-quality, high-variety, high-novelty impacts across all 11 social impact categories during an ideation session, as opposed to focusing too heavily on a subset of impact categories. The questions (treatment) do this without reducing the quantity, quality, or novelty of impacts identified, compared to the control group. In addition, using a 90% confidence interval, the 55 questions cause teams to more evenly identify impacts when low quality, low variety, and low novelty are not filtered out. As a point of interest, the case where low quality and low variety impacts are removed – but low novelty impacts are not – the treatment draws the same conclusion but with only 85% confidence.
Enhancing the Performance of a Rooftop Solar Chimney Through Flow Disturbers
Authors: Zamora Blas 
Published: September 2023

Abstract
Enhancing the performance of passive solar chimneys constitutes a key point for successful applications in bioclimatic architecture. Present work assesses applications of several kinds of flow disturbers in a rooftop solar chimney, under isoflux heating and windless conditions, and including surface radiative effects. Systematic numerical calculations are conducted aiming a comprehensive analysis, by means of a low-Reynolds turbulence model, being the range of Rayleigh number considered 2.170 × 1012 − 2.170 × 1013. Effect of different geometrical parameters is analyzed, although main attention is posed on the influence of disturbers elements on the thermohydraulic behavior of the established airflow, for obtaining best performance conditions. Some obstacles cause a clear decrease in the efficiency of the system, but given disturbers appropriately located produce valuable enhancements in the thermal or dynamic efficiency. Insertion of intermediate plates proves to be the best option, achieving maximum increases of even approximately 50% in the ventilation capacity.
Structure of Fluctuations in the Edge Plasma of a Stellarator in Modes with Transport Transitions
Authors: Vasil’kov D. G. , Skvortsova N. N. , Kharchev N. K. 
Published: September 2023

Abstract
The evolution of fluctuating signals from electrostatic and magnetic probes and reflectometry on the L-2M stellarator is presented. The L-2M facility is a quasi-stationary toroidal magnetic trap in which plasma is generated and heated by high-power pulsed microwave radiation. Pulses with transitions to improved confinement modes accompanied by an increase in energy, increase in plasma density, and restructuring of the peripheral electric field, were analyzed. Spectral analysis of signals is carried out using Fourier analysis and various wavelets. The possible influence of magnetohydrodynamic and kinetic instabilities on the development of transient processes is considered.
Advances in the care of breast cancer survivors
Authors: Cathcart-Rake Elizabeth J , Tevaarwerk Amye J , Haddad Tufia C , D’Andre Stacy D , Ruddy Kathryn J 
Published: September 2023

Abstract
Breast cancer survivors may experience significant after effects from diagnoses of breast cancer and cancer directed therapies. This review synthesizes the evidence about optimal management of the sequelae of a diagnosis of breast cancer. It describes the side effects of chemotherapy and endocrine therapy and evidence based strategies for management of such effects, with particular attention to effects of therapies with curative intent. It includes strategies to promote health and wellness among breast cancer survivors, along with data to support the use of integrative oncology strategies. In addition, this review examines models of survivorship care and ways in which digital tools may facilitate communication between clinicians and patients. The strategies outlined in this review are paramount to supporting breast cancer survivors’ quality of life.
Full NLO QCD predictions for Higgs-pair production in the 2-Higgs-doublet model
Authors: Baglio J. , Campanario F. , Glaus S. , Mühlleitner M. , Ronca J. , Spira M. 
Published: September 2023

AbstractAfter the discovery of the Higgs boson in 2012 at the CERN Large Hadron Collider (LHC), the study of its properties still leaves room for an extended Higgs sector with more than one Higgs boson. 2-Higgs doublet models (2HDMs) are well-motivated extensions of the Standard Model (SM) with five physical Higgs bosons: two CP-even states h and H, one CP-odd state A, and two charged states $$H^\pm _{}$$

H

±

. In this letter, we present the calculation of the full next-to-leading order (NLO) QCD corrections to hH and AA production at the LHC in the 2HDM at small values of the ratio of the vacuum expectation values, $$\tan \beta $$

tan
β

, including the exact top-mass dependence everywhere in the calculation. Using techniques applied in the NLO QCD SM Higgs pair production calculation, we present results for the total cross section as well as for the Higgs-pair-mass distribution at the LHC. We also provide the top-quark scale and scheme uncertainties which are found to be sizeable.
Associations between Longer Leukocyte Telomere Length and Increased Lung Cancer Risk among Never Smokers in Urban China
Authors: Wong Jason Y.Y. , Shu Xiao-Ou , Hu Wei , Blechter Batel , Shi Jianxin , Wang Kevin , Cawthon Richard , Cai Qiuyin , Yang Gong , Rahman Mohammad L. , Ji Bu-tian , Gao Yutang , Zheng Wei , Rothman Nathaniel , Lan Qing 
Published: September 2023

Abstract

Background:
The complex relationship between measured leukocyte telomere length (LTL), genetically predicted LTL (gTL), and carcinogenesis is exemplified by lung cancer. We previously reported associations between longer pre-diagnostic LTL, gTL, and increased lung cancer risk among European and East Asian populations. However, we had limited statistical power to examine the associations among never smokers by gender and histology.

Methods:
To investigate further, we conducted nested case–control analyses on an expanded sample of never smokers from the prospective Shanghai Women's Health Studies (798 cases and 792 controls) and Shanghai Men's Health Studies (161 cases and 162 controls). We broke the case–control matching and used multivariable unconditional logistic regression models to estimate the ORs and 95% confidence intervals (CI) of incident lung cancer and adenocarcinoma (LUAD), in relation to LTL measured using quantitative PCR and gTL determined using a polygenic score. In addition, we conducted Mendelian randomization (MR) using MR-PRESSO.

Results:
We found striking dose–response relationships between longer LTL and gTL, and increased lung cancer risk among never-smoking women (P trendLTL = 4×10−6; P trendgTL = 3×10−4). Similarly, among never-smoking men, longer measured LTL was associated with over triple the risk compared with those with the shortest (OR, 3.48; 95% CI, 1.85–6.57). The overall results were similar for LUAD among women and men. MR analyses supported causal associations with LUAD among women (OR1 SD gTL, 1.19; 95% CI, 1.03–1.37; P = 0.03).

Conclusions:
Longer pre-diagnostic LTL is associated with increased lung cancer risk among never smokers.

Impact:
Our findings firmly support the role of longer telomeres in lung carcinogenesis.
Can lithium contents in mica be correctly calculated? Tischendorf́s proposal (Mineralogical Magazine 61/1997) 25 years after
Authors: Breiter Karel , Vašinová Galiová Michaela , Korbelová Zuzana , Hložková Michaela 
Published: September 2023

AbstractMicas are the most common hosts of lithium in granitoid igneous rocks. Unfortunately, their Li contents cannot be determined by electron-probe microanalysis (EPMA) which is the most common method of mineral analysis. In an effort to avoid the use of other, technically more complex and expensive methods, several empirical schemes for the estimation of Li-contents from EPMA data have been developed. The methods proposed by Tischendorf (Mineralogical Magazine, 1997) have found the widest application. After 25 years of common usage, we have evaluated these methods by direct Li determination using laser ablation-inductively coupled plasma-mass spectrometry (LA–ICP–MS). Approximately 3000 spot analyses of Li in micas from eight areas worldwide obtained by LA–ICP–MS were compared with the values yielded by the methods of Tischendorf. We conclude that none of the lithium estimation methods can compensate fully for a real local analysis by LA–ICP–MS or secondary-ion mass spectrometry (SIMS). Generally, SiO2-based estimation for trioctahedral micas provides a better match to the analysed values than F-based estimation for dioctahedral micas. The Rb-based estimation for dioctahedral micas does not provide acceptable results. The usage of averaged Si- and F-based estimations can be accepted in common petrological studies for a general characterisation of mica species. Large errors of individual spot estimations preclude their usage in detailed mineralogical studies.
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β1-adrenoceptor autoantibodies
Authors: Zhi Xiaoyan , Shi Shu , Li Yang , Ma Mingxia , Long Yaolin , Li Chen , Hao Haihu , Liu Huirong , Wang Xiaohui , Wang Li 
Published: September 2023

Abstract
Background
Cardiomyocyte death induced by autophagy inhibition is an important cause of cardiac dysfunction. In-depth exploration of its mechanism may help to improve cardiac dysfunction. In our previous study, we found that β1-adrenergic receptor autoantibodies (β1-AAs) induced a decrease in myocardial autophagy and caused cardiomyocyte death, thus resulting in cardiac dysfunction. Through tandem mass tag (TMT)-based quantitative proteomics, autophagy-related S100a9 protein was found to be significantly upregulated in the myocardial tissue of actively immunized mice. However, whether S100a9 affects the cardiac function in the presence of β1-AAs through autophagy and the specific mechanism are currently unclear.

Methods
In this study, the active immunity method was used to establish a β1-AA-induced mouse cardiac dysfunction model, and RT-PCR and western blot were used to detect changes in gene and protein expression in cardiomyocytes. We used siRNA to knockdown S100a9 in cardiomyocytes. An autophagy PCR array was performed to screen differentially expressed autophagy-related genes in cells transfected with S100a9 siRNA and negative control siRNA. Cytoplasmic nuclear separation, co-immunoprecipitation (Co-IP), and immunofluorescence were used to detect the binding of S100a9 and hypoxia inducible factor-1α (HIF-1α). Finally, AAV9-S100a9-RNAi was injected into mice via the tail vein to knockdown S100a9 in cardiomyocytes. Cardiac function was detected via ultrasonography.

Results
The results showed that β1-AAs induced S100a9 expression. The PCR array indicated that Atg9a changed significantly in S100a9siRNA cells and that β1-AAs increased the binding of S100a9 and HIF-1α in cytoplasm. Knockdown of S100a9 significantly improved autophagy levels and cardiac dysfunction.

Conclusion
Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.
From common to rare: repurposing of bempedoic acid for the treatment of glycogen storage disease type 1
Authors: Das Anibh M. 
Published: September 2023

AbstractHypoketotic hypoglycaemia is a biochemical hallmark of glycogen storage disease type 1 (GSD1). This is due to inhibition of carnitine-palmitoyl transferase 1 by malonyl-CoA. This inhibits the influx of long-chain fatty acids into the mitochondrial matrix for fatty acid oxidation. This leads to reduced hepatic ketogenesis and impaired energy production in the liver and kidney. Hypoketotic hypoglycaemia may result in CNS symptoms due to energy depletion.Recently, it was reported that enzymes involved in mitochondrial long-chain fatty acid oxidation are upregulated in PBMC from patients suffering from GSD1.I suggest that administration of the prodrug bempedoic acid results in reduced production of malonyl-CoA by inhibiting the ATP-citrate lyase, thus releasing the block of mitochondrial long-chain fatty acid influx. These fatty acids could make use of the increased capacity of fatty acid oxidation as observed in PBMC recently. In the liver, ketogenesis is activated, and energy production is increased in both the liver and kidney. This could result in improved metabolic control and avoidance of cerebral energy depletion.Bempedoic acid is approved as medication in adult patients with hypercholesterolaemia and mixed dyslipidaemia. Repurposing bempedoic acid for the use in GSD1 may improve metabolic control in GSD1.
Efficacy of intravitreal dexamethasone implant used as monotherapy for the treatment of macular edema in non-infectious uveitis: a retrospective analysis
Authors: Gupta Rishi B. , Ilin Julius , Gottlieb Chloe C. 
Published: September 2023

Abstract
Background
Uveitic macular edema is a complication of acute or chronic uveitis. Current treatment regiments frequently have numerous side effects, often requiring supplemental treatment. This study investigates the efficacy of dexamethasone (DEX) intravitreal implants as monotherapy for treatment of macular edema in non-infectious intermediate, posterior or panuveitis.

Methods and results
Retrospective chart review of thirty patients with intermediate, posterior and panuveitis treated with DEX. Outcomes measured were central retinal thickness (CRT) and best corrected visual acuity (BCVA). Baseline measurements of CRT and BCVA were measured within 1 month prior to intravitreal DEX implant and follow up measurements were collected until 1 year post implant. 48 implants on 39 eyes of 30 patients were included in this study; 64.1% of patients had an improvement in BCVA and 65.4% had a reduction in CRT. BCVA improved from 0.285 logMAR (SD: 0.312) at baseline to 0.175 logMAR (SD: 0.194) at 1 month and was sustained thereafter. Preliminary CRT data showed a decrease from 392 $$\mu m$$

μ
m

(SD: $$161\mu m$$

161
μ
m

) at baseline to 303 $$\mu m$$

μ
m

(SD: $$80\mu m)$$

80
μ
m
)

at 1 month and 313 $$\mu m$$

μ
m

(SD: $$44\mu m)$$

44
μ
m
)

at 12 months.

Conclusions
The DEX implant as monotherapy for macular edema in non-infectious uveitis was associated with a reduction in CRT and improvement in BCVA. The DEX implant, used as a monotherapy in eyes with intermediate, posterior and panuveitis, has the potential to treat uveitis without oral corticosteroid or other immunomodulatory therapy.