bluuebunny/crossref_metadata_2025_split huggingface dataset:
PS-C34-4: EVALUATION OF EFFECTS ON BP AND CHOLESTEROL CHANGES AFTER MULTIPLE IMPUTATION FOR MISSING VALUES IN OBSERVATIONAL STUDY DATA OF POLYPILL
Authors: Son Chanseok , Lee Juneyoung 
Published: January 2023

Purpose:
The purpose of this study is to prove the effect of polypill on BP and cholesterol reduction effects by analyzing observational study data including missing.

Method:
Medical records were collected for a minimum of 8 weeks and a maximum of 24 weeks after the first prescription of the polypill for each subject for patients who changed their administration to the polypill, which was collected in a retrospective observational study at 71 centers in Korea. In the collected data, there were 1412 subjects, but at 8 weeks, 16 weeks, and 24 weeks, BP and cholesterol information were 30–50% or more missing.
Therefore, the available data were analyzed with GLM and LMM, and complete case data with missing removed and the imputed data by MICE estimated with pmm algorithm at all time points were analyzed by LMM.

Results:
As a result of analyzing the available data with GLM in the improvement effect of SBP, it decreased relatively linearly until the 24th week, and as a result of analyzing the complete case data with LMM, overestimation appeared. However, as a result of analyzing the available data by MICE and LMM, the effect appears until the 8th week, which can be judged as relatively normal data, and is maintained thereafter. Available data can also be analyzed by LMM, and in this case, when the missingness is less than 50%, the results are similar to the case with MICE and LMM analysis. The improvement effects of DBP and LDL-C were similar to SBP.
According to the data of this observational study, the administration of the polypill reduced SBP by 3.7 mmHg, DBP by 2.8 mmHg, and LDL-C by 14.8 mg/dL within 8 weeks of comsuming the polypill compared to the previous treatment. The effect was well maintained by 24 weeks.

Conclusion:
Interpretation of such RWD requires a lot of attention. Basically, errors in analyzing repeatedly measured data with GLM and errors in randomly deleting subjects with missing data should be taken care of. In addition, if there are less than 50% missing, it is convenient to LMM the available data, but if there are more than 50% missing, an unreasonable result has shown.
In conclusion, it is expected that the change of administration to polypill can show additional improvement effects in the control of blood pressure and lipids in patients who are taking two or more of the existing antihypertensive and antidyslipidemic drugs at the same time.
PS-C34-7: EFFECT OF FEBUXOSTAT ON THE LEVEL OF MALONDIALDEHYDE-MODIFIED LOW-DENSITY LIPOPROTEIN, AS AN OXIDANT MARKER, FROM THE SUB-ANALYSES OF PRIZE STUDY
Authors: Teragawa Hiroki , Tanaka Atsushi , Fujii Yuichi , Ueda Tomohiro , Nomura Shuichi , Node Koichi 
Published: January 2023

Background:
Febuxostat is a selective xanthine oxidase inhibitor that has been reported to possess antioxidant properties in experimental and animal studies. We previously conducted the program of vascular evaluation under uric acid control by xanthine oxidase inhibitor, febuxostat: multicenter, randomized controlled (PRIZE) study to evaluate the progression of carotid lesions in asymptomatic hyperuricemic patients with carotid atherosclerosis treated with febuxostat for 2 years compared with a control group. In the present sub-analysis study of the PRIZE study, the effect of febuxostat on the level of malondialdehyde modified low density lipoprotein (MDA-LDL), one of the oxidative stress markers, was examined.

Methods:
The subjects were 381 patients enrolled in the PRIZE trial for whom MDA-LDL measurements were available at baseline and at 24 months (182 in the febuxostat group and 199 in the control group). Uric acid (UA) levels, MDA-LDL levels, and MDA-LDL/LDL-C were determined, expressed as the estimated difference from baseline to 24 months, and compared between the two groups. We also examined the relationship between febuxostat dose (10 mg, 20–40 mg, 40–60 mg) and changes in MDA-LDL or MDA-LDL/LDL-C.

Results:
Febuxostat significantly reduced the level of UA, compared with that in the control group, in a dose-dependent manner (p < 0.001). The estimated difference in MDA-LDL/LDL-C from baseline to 24 months was significantly lower in the Febuxostat group than that in the control group (p = 0.025), while the estimated difference in MDA-LDL from baseline to 24 months was not different in the two groups (p = 0.235). There was no significant correlation between the dose of febuxostat and the estimated difference in MDA-L/LDL-C (p = 0.626). Conclusions: In asymptomatic hypereuricemia patients with carotid atherosclerosis, febuxostat may have some antioxidant effect, but the effect may not be dose-dependent.
PS-C37-3: MULTIPLE VISITS TO THE EMERGENCY SERVICE - A CASE OF NUTCRACKER SYNDROME
Authors: Pinto Pedro David Teixeira Marques 
Published: January 2023

Background:
Nutcracker Syndrome (NS) is a rare clinical entity consisting of compression of the left renal vein by the superior mesenteric artery as it travels between it and the abdominal aorta. The compressive process leads to different levels of extrinsic renal artery stenosis, from asymptomatic episodes to episodes of macroscopic hematuria, proteinuria, renovascular hypertension, left flank pain, dyspareunia, dysmenorrhea and pelvic varicose veins. It is more prevalent in females and it can be diagnosed at any age, but particularly during the 2nd and 3rd decades of life. Renal veins Doppler ultrasonography is the exam of choice in the initial evaluation, being confirmed by imaging exams such as CT and MRI. The treatment is controversial, ranging from conservative treatment to nephrectomy.

Case Description:
Between 2015 and 2022, a 24-year-old Caucasian woman, without noteworthy personal and family clinical background, resorted several times to the Emergency Department with vomiting, diarrhea and abdominal distension and pain. Numerous alternative diagnoses have been made, such as Acute Gastroenteritis, Urinary Tract Infection, among other.
Due to the large number of emergency episodes, the patient was examined by gastroenterologist who requested an abdominal CT, and diagnosed NS.
The patient underwent an unsuccessful left renal vein stenting, which subsequently forced a renal auto transplantation, which was performed without complications.

Take Home Message:
In the GP daily practice, establishing NS diagnosis is difficult and usually made after the exclusion of other problematics. A great level of suspicion is therefore crucial in patients with diversified clinical findings.
PS-C37-6: IDENTIFICATION OF ALDOSTERONE-DRIVER SOMATIC MUTATIONS IN CELL-FREE DNA FROM ADRENAL VEIN SAMPLES OF PRIMARY ALDOSTERONISM PATIENTS
Authors: Nazri Siti Khadijah Syed Mohammed , Zakaria Rozman , Murad Nor Azian Abdul , Muhammad Rohaizak , Tan Geok Chin , Sukor Norlela , Azizan Elena Aisha 
Published: January 2023

Objective:
Cell-free DNA fragments (cf-DNA) of tumour cells are often found in the blood downstream to the tumour due to the high apoptosis or necrosis rate of the cells. Primary aldosteronism (PA), a curable cause of secondary hypertension, are commonly due to an autonomous aldosterone-producing adenoma that harbours a somatic mutation in an aldosterone-driver gene. We thus aimed to see if genotyping of cf-DNA for mutations in aldosterone-driver genes could be used as a biomarker for APA.

Design and Methods:
Genotyping of cf-DNA from the adrenal vein samples (AVS) of PA patients was performed using the Agena MassARRAY platform and validated by Sanger sequencing. In this study, six samples of cf-DNA from the left and right adrenals of three PA patients were interrogated.

Results:
Of the three PA patients, two had left adrenalectomy and one had right adrenalectomy. CTNNB1 S45 mutation was detected by the Agena MassArray platform in the cf-DNA of both right adrenal and left adrenal vein samples of all patients (Patient 1, Patient 2 and Patient 3). In Patient 1, Sanger sequencing confirmed a CTNNB1 S45del mutation in both cf-DNA of right adrenal and left adrenal vein samples. In Patient 3, who was found to have left adrenal hyperplasia, the cf-DNA of the right adrenal and left adrenal vein samples was also detected to have a KCNJ5 G151R mutation by the Agena MassArray platform which was confirmed by Sanger sequencing. Interestingly, only the cf-DNA of the left adrenal was found to have a CACNA1D S672L mutation in Patient 3.

Conclusion:
These results suggest that genotyping cf-DNA from AVS samples are able to detect aldosterone-driver mutations present in the APA. However, as AVS is an invasive procedure, it would be best if genotyping of cf-DNA from periphery blood can be performed. Therefore, further work is needed to ensure this strategy can be non-invasive as then it can be used as a screening method before AVS.
PS-P11-1: ASSESSING THE KNOWLEDGE, ATTITUDE AND AWARENESS OF URBAN HYPERTENSIVE PATIENTS FOR METABOLIC SYNDROME
Authors: Patil Vishal , Patil Mansi 
Published: January 2023

Objectives:
The aim of this study was to assess the awareness, knowledge, and attitude of hypertensive patients for metabolic syndrome and its relation to demographic data in those attending the out-patient services.

Design and Methods:
400 known hypertensive patients between the age 18–60 years were recruited. Data was collected using a 2-parts closed ended questionnaire using a 4-point Likert scale. Data was analysed using both descriptive and inferential statistics (student's t-test, Pearson correlation coefficient and Spearman correlation coefficient).

Results:
A significant relationship was established between knowledge score and age of the participants (p = 0.002), but not between age and awareness and attitude (p > ; 0.05). A significant relation was observed between the duration of metabolic syndrome and knowledge score (p < 0.05). There is a significant relationship between knowledge score and educational level (p < 0.05). There is a significant difference between men's and women's awareness scores (p < 0.005), but this difference is not seen in other aspects (knowledge, attitude) (p > ; 0.05). Women's awareness score was more than men's (p = 0.0007). Data analysis showed that there is a significant relationship between awareness and knowledge (P = 0.003), and awareness and attitude (P = 0.0001).

Conclusions:
The participants’ blood pressure was not controlled in spite of good awareness and attitude. The knowledge score was low and community-based programs to improve knowledge should be initiated. Programs like May Measurement Month, regular BP screenings, and awareness around medication compliance should be encouraged in the community.
PS-P11-2: THE PATTERN OF PHYSICAL DISABILITY AND DETERMINANTS OF ACTIVITIES OF DAILY LIVING AMONG DIABETIC PATIENTS IN BANGLADESH: A CROSS-SECTIONAL ANALYSIS.
Authors: Ahmed Sabrina , Faruque Mithila , Moniruzzaman Mohammad , Roby Naym Uddin , Ashraf Fatema , Miura Katsuyuki , Ahmed MSA Mansur 
Published: January 2023

Objective:
Diabetes mellitus is a known predictor of physical disability and decline in activities of daily living (ADL); however, there are existing controversies about the factors explaining the association between diabetes and disability. Therefore, we assessed the proportion of physical disabilities and possible factors associated with ADL decline among diabetic patients in Bangladesh.

Design and Methods:
We conducted a cross-sectional study among 480 diabetic individuals from a tertiary level hospital in Dhaka, Bangladesh, aged between 40 and 85 years. For determining the ADL decline, we used the Katz Index Scoring, the highest score of 6 indicates no ADL decline. We divided patients into two groups depending on ADL impairment to compare the population characteristics using the unpaired Students t-test or Wilcoxon rank-sum test for continuous variables and the chi-squared test for categorical variables. Age, sex, educational attainment, household expenditure, BMI, HbA1c, hypertension, and medication adherence to anti-diabetic drugs were included in the statistical models. We defined any ADL decline as an event, and multivariable logistic regression was performed to assess the factors associated with ADL decline.

Results:
The mean age of the participants was 59.0 (standard deviation [SD], 7.0) years. The majority of the participants (76.3%) had at least some sort of physical disability. Age, educational attainment, household expenditure, systolic blood pressure, waist circumference, quality of life, and comorbidities were different among the groups stratified by ADL impairment status. In multivariable logistic regression analysis after adjusting for all covariates simultaneously, age (OR, 95% CI: 1.35, 1.20–1.75), lower educational attainment (0.97, 0.94–0.99), BMI (1.40, 1.12–1.75), existing comorbidities (2.79, 1.48–5.25) and uncontrolled diabetes (1.35,1.10–1.45) were independently associated with ADL decline among diabetic population.

Conclusions:
Physical disability was common, and ADL decline was associated with age, educational attainment, BMI, comorbidities, and uncontrolled diabetes among diabetic patients in Bangladesh.
PS-P12-11: INFECTION CONTROL PRACTICES OF HEALTHCARE WORKERS INFECTED WITH COVID-19 IN TONDO MEDICAL CENTER FROM MARCH 2020 TO MAY 2021
Authors: Gracilla Sheryl Joy Esteban , Quebral Joseph 
Published: January 2023

Background:
COVID-19 has put the lives of our healthcare workers at the forefront of the battle against pandemic. Understanding how this pandemic directly affects them is vital in ensuring safe and continuous provision of service to the public. Reviewing their infection control practices is imperative in protecting their health and the patients they serve. This study aimed to determine the infection control practices of healthcare workers infected with COVID-19 in Tondo Medical Center from March 2020 to May 2021.

Methodology:
This is descriptive retrospective study involving healthcare workers of Tondo Medical Center infected with COVID-19 from March 2020 to May 2021. Demographic data, exposure history, clinical manifestations and infection control practices data were surveyed, encoded and tabulated. Categorical variables were presented as frequencies and percentages.

Results:
A total of 425 healthcare workers developed COVID-19 from March 2020 to April 2021. Their mean age was 36.4 years; more female (57.4%) and single (56.0%) staff were affected. Most cases (41.4%) came from or low/lowest risk areas. Three clustering of cases were identified. More than half of the respondents (54.4%) had unknown exposure; housemates/relatives (21.0%) were the most common source of known exposure. Three out of 10 respondents were asymptomatic; majority had mild symptoms (62.2%), the most common of which was the loss of taste/smell (26.5%). Adherence to wearing of mask was highest in the community (99.5%) than in the workplace (93.4%) and least at home (78.3%). Majority practiced social distancing in the community (97.9%) and in the workplace (95.5%). Almost half (58.7%) practiced 1-meter social distancing. Respondents practiced frequent handwashing both at home (92.2%) and in the workplace (91.9%). Only 1–2 out of 10 washed their hands for 40 seconds or more. Majority employed hand hygiene with alcohol-based rub for less than 20 seconds in the workplace (71.6%) and at home (69.5%). Majority (98.3%) performed hand hygiene after coughing or sneezing and used tissue (44.4%). Most of the respondents decontaminated their work area before and after work (66.6%). Alcohol was most used in the workplace (70.7%). More than half (59.6%) ate in the pantry, mostly alone (65.5%). Most cleaned their cellphones daily (88.4%). Majority brought alcohol with them (97.2%) and almost half (47.5%) wore a mask for 4–8 hours.

Conclusion:
Some gaps have been identified in the knowledge and practices of infection control of healthcare workers infected with COVID-19 at Tondo Medical Center; hence reinforcement programs including refresher trainings and policy enhancement are warranted.
PS-P13-4: THE CONTRIBUTION OF RAISED BLOOD PRESSURE TO THE BURDEN OF CARDIOVASCULAR DISEASE AND DEATHS IN AUSTRALIA FROM 1990 TO 2019
Authors: Xu Xiaoyue , Islam Sheikh Mohammed Shariful , Schlaich Markus , Jennings Garry , Schutte Aletta 
Published: January 2023

Objective:
The 2019 Global Burden of Disease (GBD) findings highlight raised systolic blood pressure (SBP) as the leading cause of death globally. In a high-income country, Australia, it is unclear how SBP ranks among other risk factors regarding the overall and cardiovascular disease (CVD) burden, and whether the situation has changed over time.

Design and method:
We analysed the 2019 GBD data with a focus on Australia. We assessed the ten leading risk factors for all-cause and CVD deaths and disability-adjusted life-years (DALYs) and compared findings with the Australia Burden of Diseases Study.

Results:
From 1990 to 2019, raised SBP remained the leading risk factor for attributable deaths (followed by dietary risks and tobacco use), accounting for 29,056/75,235 (39%) (95% Uncertainty Interval (UI) [24,863–32,915]) deaths in 1990; 21,845/76,893 (28%) [17,678–26,044] in 2010; and 25,498/90,393 (28%) [20,152–30,851] in 2019. From 1990 to 2019, contributions of SBP to cardiovascular deaths were 54% [46–62], 44% [37–51] and 44% [36–52]. Recently (2010 to 2019), the contribution of SBP to cardiovascular deaths and DALYs increased in males (9,361/17,551 (53%) deaths in 2010 to 11,042/20,420 (54%) in 2019; and 181,127/325,783 (56%) to 203,677/359,931 (57%) DALYs) and females (10,184/18,047 (56%) cardiovascular deaths in 2010 and 11,228/19,811(57%) in 2019; and DALYs from 140,625/240,510 (58%) to 154,013/260,348 (59%)).

Conclusions:
Raised SBP continues to be the leading risk factor for all-cause and cardiovascular deaths in Australia. We urge cross-disciplinary stakeholder engagement to implement effective strategies to detect, treat and control raised blood pressure as a central priority to mitigate the CVD burden.
PS-P14-3: EFFORTS OF “S-1 GRAND PRIX”, A DELICIOUS LESS SALT RECIPE CONTEST AIMED AT PREVENTING CARDIOVASCULAR DISEASES
Authors: Sato Kaoru , Watanabe Sachie , Nagao Nobuyuki , Takemoto Sayuri , Watanabe Satomi , Kawabata Nao , Masuzaki Miku , Ohtani Misato , Tanaka Katsuhisa , Akagawa Eiki , Asano Shigehiro , Miyamoto Yoshihiro 
Published: January 2023

Purpose:
As the average salt intake of Japanese people is as high as 10 gram per day, it is necessary to reduce the salt intake for the prevention and treatment of cardiovascular diseases. We held a less salt recipe contest to promote delicious less salt recipes among society and examined the potentiality of “deliciously less salt meals”.

Method:
National Cerebral and Cardiovascular Center (NCVC) held the “The 5th S-1 Grand Prix”, a contest to develop delicious and less salt bento recipes on a nationwide scale. The contest named after its goal of reducing the salt intake by 1 gram in each meal. Under the theme of a delicious and attractive less salt bento meeting to the nutritional value standards (such as less than 2 gram of salt equivalent per meal), NCVC called for the bento recipe ideas from the 10th of May to 26th of July 2021. All the applied recipes are evaluated and tasted by NCVC contest board members, then the best one was decided for a “Grand-Prix” award. Contest was held on-line due to the COVID-19, the video presentation made by the applicants were evaluated for the final selection.

Result:
A total of 67 teams (25 teams in the general category, 15 teams in the student category, 27 teams in the disaster nutrition category) were applied to this contest. We encouraged governments, hospitals, dietitian training schools, and convention-related companies and organizations nationwide to apply the contest. Compared to the 4th tournament, the number of applicants were increased by 16 teams. More than half of the applicants were from “educational institutions such as universities”. Although the 5th tournament was held online, we were able to hold a recipe contest in a new format, such as using applicants’ video presentation for the final selection.

Discussion:
In the disaster nutrition category, many recipes for the delicious, preserved foods and cooking methods under the disaster were gathered, so that these less salt recipes can be widely adopted in the disaster foods. Through this attempt, we created an opportunity to make a delicious less salt meals, and motivated participants to cook “deliciously less salt meals”. In the future, more people will participate in this contest in order to get them to participate, we will consider the conditions of the recipe and the recruitment method.
PS-P14-5: THE LINK BETWEEN SALT KNOWLEDGE, SALT REDUCTION AWARENESS AND SALT REDUCTION BEHAVIOR
Authors: Nakamura Satoko 
Published: January 2023

Objective:
The effects of salt on health are well known. However, salt intake is still high in Japan and the number of hypertensive patients is increasing. Therefore, we investigated the association between knowledge, awareness, and behavior towards salt among university students.

Design and Methods:
72 university students (11 males and 61 females) from the Department of Nutrition (group N) and 70 university students (10 males and 60 females) from other departments than nutrition (group O) was included in the study. Knowledge and awareness of salt and their behavior were investigated using questionnaires and a salt checklist.

Results:
In terms of knowledge of salt, the target amount of salt intake (g/day) was answered as 7.2 ± 0.6 in group N and 15.0 ± 13.9 in group O, with no significant difference. When the target amount of 7–8 g/day of the Japanese Dietary Reference Intakes was used as the correct answer range, the percentage of correct answers was 86% in group N and 10% in group O (p < 0.001). The correct answer rate for seasonings with high salt content was 86% in group N and 27% in group O (p < 0.0001). There was no significant difference in the percentage of correct answers for low-salt condiments. The percentage of correct answers for diseases associated with salt intake was significantly higher in group N. The proportion with low-salt awareness was significantly higher in group N (p < 0.0001). The total score on the salt checklist was 10.7 ± 3.0 in group N and 13.4 ± 4.7 in group O (p < 0.0005).

Conclusion:
The students from the Department of Nutrition had a higher level of salt reduction awareness, more knowledge about salt and a lower total score on the salt checklist. Medical and food knowledge may be useful in linking salt reduction knowledge with awareness and behavior.