bluuebunny/crossref_metadata_2025_split huggingface dataset:
IoT forensics: Exploiting unexplored log records from the HIKVISION file system
Authors: Dragonas Evangelos , Lambrinoudakis Costas , Kotsis Michael 
Published: August 2023

AbstractCCTV surveillance systems are IoT products that can be found almost everywhere. Their digital forensic analysis often plays a key role in solving crimes. However, it is common for these devices to use proprietary file systems, which frequently hinders a complete examination. HIKVISION is a well‐known manufacturer of such devices that typically ships its products with its proprietary file system. The HIKVISION file system has been analyzed before but that research has focused on the recovery of video footage. In this paper, the HIKVISION file system is being revisited regarding the log records it stores. More specifically, these log records are thoroughly examined to uncover both their structure and meaning. These unexplored pieces of evidence remain unexploited by major commercial forensic software, yet they can contain critical information for an investigation. To further assist digital forensic examiners with their analysis, a Python utility, namely the Hikvision Log Analyzer, was developed as part of this study that can automate part of the process.
Interannual patterns of avian diseases in wild New Zealand avifauna near conservation areas
Authors: Filion Antoine , Webster Trudi , Poulin Robert , Godfrey Stephanie S. 
Published: August 2023

AbstractThe past few years have seen a noticeable increase in the emergence of infectious diseases in wildlife, especially vector‐borne diseases, presenting a challenge for the conservation of endangered species. One such vector‐borne disease, avian malaria (Plasmodium spp.) is on the rise in New Zealand avifauna, threatening bird populations that are among the most extinction‐prone in the world. Furthermore, recent reports have outlined an increase in deaths of native iconic bird species specifically due to this disease. In order to help manage breakouts of this pathogen at a local scale, we need a better understanding of potential drivers of the emergence of avian malaria in wild New Zealand avifauna. Here, we set to test the role of climatic drivers in synchronizing contacts between avian hosts and vectors, assess the temporal stability of transmission dynamics between years, and determine the role of introduced species in causing spill‐over of this pathogen towards native species. Our study focused on three sites that were sampled regularly during two consecutive years in the austral summer, each site being adjacent to a breeding colony of Yellow‐eyed penguins (Megadyptes antipodes). Our results reveal an overall temporal stability of avian malaria incidence patterns, with a decrease in infection throughout the austral summer for both sampled years. Moreover, we highlight a phylogenetic signal among sampled bird species, with introduced species being more heavily infected by avian malaria than their native counterparts. In contrast, we found no effect of the two climatic drivers investigated, temperature and rainfall, on mosquito abundance. Our results suggest a strong effect of alien species acting as reservoirs for diseases spilling‐over towards immunologically naïve species, and provide conservation managers with a critical timeframe to control avian malaria breakouts.
Clinical evaluation of culturable bacteria, endotoxins and lipoteichoic acid in teeth with vital normal pulp tissues
Authors: Chiarelli‐Neto Vito M. , de Aveiro Emelly , Bronzato Juliana D. , Arruda‐Vasconcelos Rodrigo , Louzada Lidiane M. , Godoi Ederaldo P. , Lopes Erica M. , de‐Jesus‐Soares Adriana , Ferraz Caio C. R. , Almeida José F. A. , Marciano Marina A. , Gomes Brenda P. F. A. 
Published: August 2023

AbstractThe objective of this study was to investigate the presence of culturable bacteria, endotoxins (LPS) and lipoteichoic acid (LTA) levels in teeth with normal vital pulp (NVP) with intact crowns (IC) and those with coronal restoration (CR) limited to the enamel level. A total of 20 teeth indicated for endodontic treatment due to prosthetic reasons were selected. Samples were collected from the root canals. The levels of cultivable bacteria, LPS and LTA were assessed. Statistical analyses were performed at significance level set at 5%. None of the teeth presented microbial growth. In the IC group, the LPS levels were limited to the lowest concentration of LPS. On the contrary, higher LPS and LTA levels were detected in teeth with CR. It was concluded that teeth with NVP and IC were negative for bacteria, LPS and LTA; while teeth with CR were positive for bacterial virulence factors.
Internal Information Quality and Corporate Employment Decisions
Authors: Choi Ahrum , Lee Woo‐Jong , Lee Yong Gyu , Zhou Gaoguang 
Published: August 2023

AbstractPrior studies argue that high‐quality internal information improves forecasting and reduces internal information asymmetry, and hence facilitates firms’ decision‐making. Consistent with this argument, we find that internal information quality (IIQ) is positively associated with employment efficiency. Furthermore, we find that better IIQ leads to an improvement in employment efficiency primarily by improving demand forecasts. The baseline finding is robust to using a setting that exploits time‐series shocks to IIQ (i.e., the adoption of SFAS 158) and other sensitivity analyses. Our findings add to prior studies on the role of IIQ in decision‐making.
Biallelic ANKS6 null variants cause notable extrarenal phenotypes in a nephronophthisis patient and lead to hepatobiliary abnormalities by YAP1 deficiency
Authors: Liu Keqiang , Chen Ru , Wang Xiaoying , Gong Yiming , Shi Jia , Gu Beilin , Zhou Ying , Cai Wei 
Published: August 2023

AbstractThe ankyrin repeat and sterile alpha motif domain containing 6 (ANKS6) gene, encoding an inversin compartment protein of the primary cilium, was recently reported as a pathogenic gene of nephronophthisis (MIM PS256100). Extrarenal manifestations are frequently observed in this disease, however, potential genotype–phenotype correlations and the underlying mechanisms remain poorly understood. Here we described an infant with kidney failure, hepatobiliary abnormalities, and heart disease, in whom whole exome sequencing identified compound heterozygous variants in ANKS6, including a novel nonsense variant p.Trp458* and a recurrent splicing variant c.2394+1G > A. mRNA expression studies showed that the splicing variant caused aberrant mRNA splicing with exon 13 skipping and the biallelic variants were predicted to cause loss of ANKS6 function. We systematically characterized the clinical and genetic spectra of the disease and revealed that biallelic null variants in ANKS6 cause more severe kidney disease and more extrarenal manifestations, thus establishing a clear genotype–phenotype correlation for the disease. Further evaluations showed that ANKS6 deficiency reduced YAP1 expression in the patient's bile duct epithelium and ANKS6 promotes YAP1 transcriptional activity in a dose‐dependent manner, indicating that loss of ANKS6 function causes hepatobiliary abnormalities through YAP1 deficiency during biliary morphogenesis and development, which may offer new therapeutic targets.
Lateral sinus floor elevation in patients with sinus floor defects: A retrospective study with a 1‐ to 9‐year follow‐up
Authors: Wen Yifan , Wei Donghao , Jiang Xi , Zhang Yu , Di Ping , Lin Ye 
Published: August 2023

AbstractObjectivesWe aimed to retrospectively evaluate the long‐term clinical outcomes of lateral sinus floor elevation (LSFE) in patients with sinus floor defects.Materials and MethodsBetween 2008 and 2020, patients with sinus floor defects were recruited after confirmation on preoperative cone‐beam computed tomography (CBCT). The split‐thickness flap technique with a palatal crestal incision was used to manage tissue adhesion in the bone defects area. A resorbable collagen membrane was used to close the sinus floor defects from the crestal side before bone substitute placement. Of 58 implants, 47 (81.0%) were placed after an 8‐month healing period, whereas 11 were placed simultaneously. Patients were followed up by radiography and clinical examination for 1–9 years. Finally, the cumulative survival rate (CSR) of implants, surgical complications, and marginal bone loss (MBL) were recorded and analyzed.ResultsIn total, LSFE was performed in 36 sinuses (35 patients) with sinus floor defects, of which surgery was completed in 35 sinuses (97.2%) in the first attempt. Schneiderian membrane perforations (SMP) occurred in 10/36 (27.8%) sinuses; nine were repaired carefully, whereas one surgery was suspended due to complicated SMP, and successful re‐entry LSFE was performed 4 months later. After a follow‐up period of 1–9 years, the CSR was 96.5% at the 1‐year, 3‐year, 5‐year, and 7‐year follow‐ups and 64.3% at the 8‐year follow‐up.ConclusionWithin the limitations of this study, sinus floor defects seem not to compromise LSFE therapy after appropriate management and long‐term clinical outcomes are predictable.
Acoustic‐electric trigeminal‐nerve stimulation enhances functional connectivity in patients with disorders of consciousness
Authors: Wu Min , Concolato Marta , Sorger Bettina , Yu Yamei , Li Xiaoxia , Luo Benyan , Riecke Lars 
Published: August 2023

AbstractAimDisruption of functional brain connectivity is thought to underlie disorders of consciousness (DOC) and recovery of impaired connectivity is suggested as an indicator of consciousness restoration. We recently found that rhythmic acoustic‐electric trigeminal‐nerve stimulation (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) in the gamma band can improve consciousness in patients with DOC. Here, we investigated whether these beneficial stimulation effects are mediated by alterations in functional connectivity.MethodsSixty‐three patients with DOC underwent 5 days of gamma, beta, or sham acoustic‐electric trigeminal‐nerve stimulation. Resting‐state electroencephalography was measured before and after the stimulation and functional connectivity was assessed using phase‐lag index (PLI).ResultsWe found that gamma stimulation induces an increase in gamma‐band PLI. Further characterization revealed that the enhancing effect is (i) specific to the gamma band (as we observed no comparable change in beta‐band PLI and no effect of beta‐band acoustic‐electric stimulation or sham stimulation), (ii) widely spread across the cortex, and (iii) accompanied by improvements in patients' auditory abilities.ConclusionThese findings show that gamma acoustic‐electric trigeminal‐nerve stimulation can improve resting‐state functional connectivity in the gamma band, which in turn may be linked to auditory abilities and/or consciousness restoration in DOC patients.
Abnormal bone marrow findings in patients following treatment with chimeric antigen receptor‐T cell therapy
Authors: Yeung Cecilia C. S. , Woolston David W. , Wu Vicky , Voutsinas Jenna M. , Basom Ryan , Davis Chris , Hirayama Alexandre V. , Naresh Kikkeri N. 
Published: August 2023

AbstractBackgroundBone marrow (BM) assessment after CAR‐T cell immunotherapy infusion is not routinely performed to monitor adverse events such as cytopenias, hemophagocytic lymphohistiocytosis, or infections. Our institution has performed BM biopsies as part of CAR‐T cell treatment protocols, encompassing pre‐ and post‐treatment time points and during long‐term follow‐up.MethodsWe conducted a systematic retrospective review of BM abnormalities observed in samples from 259 patients following CAR‐T cell immunotherapy. We correlated BM pathology findings with mortality, relapse/residual disease, and laboratory values.ResultsAt a median of 35.5 days post‐CAR‐T infusion, 25.5% showed severe marrow hypocellularity, and 6.2% showed serous atrophy, and peripheral blood cytopenias corroborated these observations. Marrow features associated with reduced disease burden post‐CAR‐T infusion include increased lymphocytes seen in 16 patients and an increase of macrophages or granulomatous response seen in 25 patients. However, a 100‐day landmark analysis also showed increased marrow histiocytes were associated with lower survival (median OS 6.0 vs. 21.4 months, p = .026), as was grade 2–3 marrow reticulin (18 patients) (median OS 12.5 vs. 24.2 months, p = .034).ConclusionsThese data represent the first systematic observations of BM changes in patients receiving CAR‐T cell immunotherapy.
Detection of proteomic alterations at different stages in a Huntington's disease mouse model via matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) imaging
Authors: Karayel‐Basar Merve , Uras Irep , Kiris Irem , Baykal Ahmet Tarik 
Published: August 2023

AbstractHuntington's disease (HD) is a progressive and irreversible neurodegenerative disease leading to the inability to carry out daily activities and for which no cure exists. The underlying mechanisms of the disease have not been fully elucidated yet. Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) allows the spatial information of proteins to be obtained upon the tissue sections without homogenisation. In this study, we aimed to examine proteomic alterations in the brain tissue of an HD mouse model with MALDI‐MSI coupled to LC–MS/MS system. We used 3‐, 6‐ and 12‐month‐old YAC128 mice representing pre‐stage, mild stage and pathological stage of the HD and their non‐transgenic littermates, respectively. The intensity levels of 89 proteins were found to be significantly different in YAC128 in comparison to their control mice in the pre‐stage, 83 proteins in the mild stage, and 82 proteins in the pathological stage. Among them, Tau, EF2, HSP70, and NogoA proteins were validated with western blot analysis. In conclusion, the results of this study have provided remarkable new information about the spatial proteomic alterations in the HD mouse model, and we suggest that MALDI‐MSI is an excellent technique for identifying such regional proteomic changes and could offer new perspectives in examining complex diseases.
Neurological side effects and drug interactions of antiviral compounds against SARS‐CoV‐2
Authors: Akhvlediani Tamar , Bernard‐Valnet Raphael , Dias Sara P. , Eikeland Randi , Pfausler Bettina , Sellner Johann ,   for the Infectious Disease Panel of the European Academy of Neurology
Published: August 2023

AbstractBackground and purposeThe COVID‐19 pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2), rapidly spread across the globe. Tremendous efforts have been mobilized to create effective antiviral treatment options to reduce the burden of the disease. This article summarizes the available knowledge about the antiviral drugs against SARS‐CoV‐2 from a neurologist's perspective.MethodsWe summarize neurological aspects of antiviral compounds against SARS‐CoV‐2 with full, conditional, or previous marketing authorization by the European Medicines Agency (EMA).ResultsNirmatrelvir/ritonavir targets the SARS‐CoV‐2 3c‐like protease using combinatorial chemistry. Nirmatrelvir/ritonavir levels are affected by medications metabolized by or inducing CYP3A4, including those used in neurological diseases. Dysgeusia with a bitter or metallic taste is a common side effect of nirmatrelvir/ritonavir. Molnupiravir is a nucleotide analog developed to inhibit the replication of viruses. No clinically significant interactions with other drugs have been identified, and no specific considerations for people with neurological comorbidity are required. In the meantime, inconsistent results from clinical trials regarding efficacy have led to the withdrawal of marketing authorization by the EMA. Remdesivir is a viral RNA polymerase inhibitor and interferes with the production of viral RNA. The most common side effect in patients with COVID‐19 is nausea. Remdesivir is a substrate for CYP3A4.ConclusionsNeurological side effects and drug interactions must be considered for antiviral compounds against SARS‐CoV‐2. Further studies are required to better evaluate their efficacy and adverse events in patients with concomitant neurological diseases. Moreover, evidence from real‐world studies will complement the current knowledge.
Where does ex‐dividend trading occur: An examination of trading venues around dividends
Authors: Cox Justin , Fuller Kathleen P. , Van Ness Robert 
Published: August 2023

AbstractWe examine the fragmentation of trading around the ex‐dividend date. We argue that the taker‐maker and dark trading venues provide potential dividend capture traders a more favorable platform than the maker‐taker venue(s) given the price improvement, lower queues, and lower net transaction costs. Our evidence indicates that taker‐maker (dark) venue market share decreases (increases) on cum‐dividend days but reverts to normal levels on the ex‐dividend day. Additionally, we find fragmented trading impacts the ex‐dividend price change and improves price efficiency. Finally, we find evidence that retail trades are associated with potential dividend‐capture trading.
Participation and co‐production for learning and development of identities: wherever I go, I meet myself
Authors: Stephens John , Carter Chris , McMahon Susan , Howard Bronwen , Scott Lesley 
Published: August 2023

AbstractBackgroundContemporary society is characterised by constant change with an ever‐increasing feature of interconnection, having clear implications for healthcare professional learning and role identity. It is proposed that active participation and coproduction for learning can provide options to understand contemporary challenges and opportunities in the development of personal and professional identity.AimsThis research aimed to explore the value of learning and development of identity through participation in co‐produced practical workshop activity involving service users and students across a Year 1 (level 4) undergraduate BSc(Hons) Physiotherapy module. Co‐production was also reflected within the research project design and operationalisation.Materials & MethodsFollowing delivery of the workshops, data were collected and analysed from a series of individual semi‐structured interviews (n = 11) and a focus group.ResultsSix emergent themes were identified. A central theme of identity and self‐worth was deconstructed within five interdependent sub‐themes; real and safe, person‐centred, backstage learning, good to talk and staging of curriculum.ConclusionA process of open dialogue within co‐produced workshop design and delivery would appear to enhance learning and a contextual appreciation of a broader ‘whole’ for all participants. Future research is aimed at building on this project, to explore co‐produced learning opportunities across levels and settings that provide further insight into personal and professional identity development.
A new gelatinous host for pelagic fishes: First in situ record of an association between driftfishes (Stromateiformes, Ariommatidae) and nudibranchs (Mollusca, Phylliroidae)
Authors: Pastana Murilo N. L. , Johnson G. David , Mundy Bruce , Datovo Alessio 
Published: August 2023

AbstractWe describe the first recorded association between fishes and nudibranchs in epipelagic waters. In situ observations and photographs of a juvenile spotted driftfish Ariomma regulus (Stromateiformes; Ariommatidae) swimming alongside the planktonic nudibranch Phylliroe lichtensteinii (Gastropoda; Phylliroidae) were made during blackwater scuba dives off Palm Beach, Florida, United States of America. In this paper, we describe this behavior, highlighting a previously undocumented zooplanktonic host used by fishes. This finding also demonstrates the importance of community science in advancing our understanding of the early life history of marine species.
What interventions keep older people out of nursing homes? A systematic review and meta‐analysis
Authors: Gaugler Joseph E. , Zmora Rachel , Peterson Colleen M. , Mitchell Lauren L. , Jutkowitz Eric , Duval Sue 
Published: August 2023

AbstractBackgroundNursing home admission remains a central outcome in many healthcare systems and community‐based programs. The objective of this meta‐analysis was to determine the efficacy of pharmacological and nonpharmacological interventions in preventing nursing home admission for adults aged 65 years or older.MethodsMEDLINE, EMBASE, PsycInfo, CINAHL, and the Cochrane Library were all last searched in March 2022 to identify up‐to‐date eligible studies for the meta‐analysis. Two reviewers screened each abstract independently. In instances where reviewers disagreed as to inclusion, all reviewers convened to review the Abstract to come to a consensus decision regarding inclusion. Two reviewers independently collected data from each report. Disagreements were resolved using group consensus. The first author reviewed the narrative descriptions of intervention components to create a categorization scheme for the various interventions evaluated in selected studies. These categorizations were reviewed with the co‐authors (second–fifth) and collapsed to create the final classification of intervention type. Study risk of bias was assessed using an instrument developed based on Agency for Healthcare Research & Quality (AHRQ) guidance. Differences between the percentages of participants in treatment versus control arms was the outcome of interest.ResultsTwo‐hundred and eighty‐three studies with a total of 203,735 older persons were included in the meta‐analysis. Specialty geriatrics care (OR = 0.77, 95% CI, 0.60–0.99), multicomponent interventions (OR = 0.82, 95% CI, 0.67–0.99), and cognitive stimulation (OR = 0.60, 95% CI, 0.38–0.96) were associated with less frequent nursing home admission. Home‐based and inpatient/discharge management interventions approached statistical significance but were not associated with reduced institutionalization.ConclusionsEven in the face of complex care needs, older adults wish to live at home. Effectively disseminating and implementing geriatric care principles across healthcare encounters could achieve a highly valued and preferred outcome in older adulthood: aging in place.
Prevalence and development of a risk score for oral human papillomavirus infection in men who have sex with men in Mexico
Authors: Carnalla Martha , Rojas‐Martínez Rosalba , Barrientos‐Gutiérrez Tonatiuh , Allen‐Leigh Betania , León‐Maldonado Leith , Gutiérrez‐Xicoténcatl Lourdes , Portillo‐Romero Alejandra J. , Nyitray Alan G. , Salmerón Jorge , Giuliano Anna R. , Lazcano‐Ponce Eduardo 
Published: August 2023

AbstractBackgroundMen who have sex with men (MSM) are at high risk for oral human papillomavirus (HPV infection). There are no specific screening guidelines to facilitate the identification of people at risk for oral HPV infection. We aimed to estimate the prevalence of oral high‐risk HPV and create a risk score to identify MSM at higher risk for prevalent oral HPV.MethodsWe collected baseline data from a clinical trial from a subsample of 500 MSM attending sexually transmitted disease treatment clinics; they provided an oral gargle sample for high‐risk HPV detection. We calculated oral high‐risk HPV prevalence and 95% confidence intervals (CIs), used a logistic regression model to identify factors associated with high‐risk HPV infection, and created a risk score.ResultsThe prevalence of any oral high‐risk HPV among MSM was 11.1% (95% CI: 8.6–14.2), with a higher prevalence observed among men living with HIV (14.8%). Factors independently associated with oral high‐risk HPV were age ≥40 years (OR = 2.71, 95% CI: 1.28–5.73 compared to <40 years), being HIV‐positive with CD4 count 200–499 (OR = 2.76, 95% CI: 1.34–5.65 compared to HIV‐negative), and recent recreational use of vasodilators (poppers/sildenafil) (OR = 2.02, 95% CI: 1.02–2.97). The risk score had good discriminatory power (AUC = 0.70, 95% CI: 0.63–0.77).ConclusionsMSM have specific predictors for prevalent oral high‐risk HPV, and a risk score could be used by clinicians to target men with vaccine recommendations and counseling, and identify those who could benefit from primary interventions given the available resources, or for referral to dental services for follow‐up when available.