bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of the Scalar and Vector Anomalous Couplings on the Z-production at ILC in the Randall - Sundrum Model
Authors: Giang Bui Thi Ha 
Published: September 2023

An attempt is made to present the effect of the scalar and vector anomalous couplings on scattering process with polarized initial beams in the Randall-Sundrum model. We have studied the contribution of radion, Higgs and gauge bosons on the Z-production cross-section at International Linear Colliders (ILC). The cross-section depends strongly on the polarization of initial beams, the center of mass energy and model interaction parameters. The obtained results indicate that with the vector anomalous couplings included Z boson and photon, the cross-sections for the Z production are much larger than that with the scalar couplings included radion and Higgs under the same conditions.
Mental Health Literacy Among Residents in Hien Chung Commune, Quan Hoa District, Thanh Hoa Province in 2022
Authors: Dang Tuan Mac , Thi Tinh Le , Thi Kim Chi Le , Thi Thu Hien Le , Bach Nguyen Xuan 
Published: September 2023

Objective: Describe the current state of mental health literacy of the community in Hien Chung commune, Quan Hoa district, Thanh Hoa province in 2022. Subjects and methods: In this cross-sectional study, a convenience sampling method was used to survey 198 participants in the commune. The data collection tools were the demographics section and the Vietnamese version of the Mental Health Literacy Scale (MHLS-VN). Results: The mean MHL total score of the sample was 79.1±13.9. Of these, the percentages of people having moderate mental health literacy and people having low mental health literacy were 66.1% and 18.2%, respectively. A small number of people with high mental health literacy accounted for 15.7%. Conclusion: People's mental health literacy is mainly low-medium.
SOSIALISASI SPORT MASSAGE PADA MASYARAKAT DESA KALOTOK KABUPATEN LUWU UTARA
Authors: Riswanto A. Heri , Kahar Irsan , Jalil Rasyidah , Hidayat Rachmat , Aliah Husnani , Firansyah Aldi 
Published: September 2023

Program PKM “Sosialisasi Sport Massage pada masyarakat desa kalotok kabupaten luwu utara” dilaksanakan sebagai bentuk pengabdian kepada masyarakat dibidang olahraga yang berada di kabupaten luwu utara. Target yang ingin dicapai dalam kegiatan ini adalah tingginya minat masyarakat terhadadap pengetahuan ilmu sport massage bagi kebugara tubuh dan kesahatan. Dalam ilmu sport massage sangat penting untuk di ketahui karna banyak manfaat untuk menjaga kebugaran tubuh dan Kesehatan. Selain itu massage juga dapat membantu meredakan stres dan ketegangan yang terkait dengan kehidupan sehari-hari. Dalam masyarakat yang sibuk dan penuh tekanan, massage dapat menjadi cara efektif untuk mengurangi tingkat stres dan menciptakan perasaan rileks. Kegiatan PKM ini diarahkan untuk “working with community” (bekerja bersama masyarakat) dan mengubah paradigma pembangunan (development) menjadi paradigma pemberdayaan (empowerment). Identifikasi beberapa Permasalahan yang ada di masyarakat diantaranya: 1) Minimnya pengetahuan masyarakat tentang ilmu sport massage, 2) kurangnya pemahaman masyarakat akan pentingnya sport massage3) Lemahnya pengetahuan teknis, Belum adanya Teknologi Tepat Guna Sederhana, serta masyarakat belum pernah diberikan pelatihan mengenai tata cara melakukan Teknik dalam melakukan sport massage. Terkait hal tersebut maka solusi yang ditawarkan yakni: Peningkatan Personal Income, 2) Pengembangan sport massage di masyarakat 3) Kaderisasi organisasi kepemudaan pengembangan organisasi kepemudaan. Adapun tindak lanjut dan program kegiatan ini yaitu: 1) Melaksanakan pelatihan massagepada masyarakat, 2) Pengenalan, praktik, dan pendampingan sport massage bagi Masyarakat.
Outcome of diagnostic laparoscopy in young patients presenting with acute nonspecific abdominal pain.
Authors: Rashid Aslam  , Haythem Abdul Shakoor  , Farrukh Ozair Shah  , Muhammad Nadir Shah  , Hamidullah  
Published: September 2023

Objective: To assess the role of diagnostic laparoscopy in young patients with Non-specific abdominal pain. Study Design: Prospective study. Setting: General Surgery Department, Hayatabad Medical Complex Peshawar. Period: January 2021 to December 2021. Material & Methods: A total of 140 young patients between the ages of 15 and 30 who had diagnostic laparoscopy for non-specific abdominal pain and met the inclusion criteria were included. Dates of admission, dates of operation, demographic and clinical information about patients were recorded. Results: 140 patients in all were enrolled. The mean age was 22.5 years, with a range of 15 to 30 years. There were 50(35.7%) females and 90(64.3%) males, of the total. Diagnoses and therapeutic treatment were feasible in 95 cases (67.8%), no pathology was found in 29 cases (20.7%), the preoperative picture was uncertain in 11 cases (7.8%), and no diagnosis was obtained following laparoscopy in 5 cases (3.6%), respectively. Conclusion: Early diagnostic laparoscopy in young patients is a safe and effective procedure. As a result, it is a useful investigative technique for acute abdominal pain that has not been properly identified.
PCSK9 Antagonists: Clinical Efficacy and Main Trends in the Development of New Medicines
Authors: Nekipelova A. A. , Alyautdin R. N. 
Published: September 2023

Scientific relevance. Cardiovascular diseases (CVD) are the leading cause of death worldwide. Dyslipidemia, as the pathophysiological basis of atherosclerosis, is the most important cause of CVD. Among the factors that modify this pathology, the World Health Organisation lists statins, which effectively reduce the cholesterol level. However, statin treatment compliance is not sufficient to achieve population-based lipid targets. This is a powerful stimulus for the creation of fundamentally new groups of lipid-lowering agents, in particular, antagonists of proprotein convertase subtilisin/kexin type 9 (PCSK9).Aim.The study aimed to review innovative approaches to developing a new generation of lipid-lowering agents, PCSK9 antagonists, and to evaluate the effectiveness, safety, and clinical potential of these medicines.Discussion.PCSK9 antagonists significantly increase the effectiveness of lipid-lowering therapy when combined with statins and are an effective monotherapy in patients with contraindications for statins. PCSK9 monoclonal antibodies, as well as inclisiran, have a favourable risk–benefit ratio. However, the high cost of commercially available PCSK9 antagonists limits their clinical use. A number of promising directions exist for developing new PCSK9 antagonists that have fundamentally different mechanisms of action, such as adnectins; genome editing with CRISPR/Cas9; combining small molecules with low molecular weight PCSK9 inhibitors; PCSK9 vaccines; and antisense oligonucleotides. Medicinal products from these groups are currently at various stages of preclinical and clinical development.Conclusions.Therefore, new lipid-lowering agents can be developed by synthesising high and low molecular weight PCSK9 ligands and by altering the genetic mechanisms of PCSK9 synthesis. The innovative medicines considered in this review are highly effective, and most have shown no signs of toxicity at the pre-authorisation stage.
Using Zebrafish in Preclinical Drug Studies: Challenges and Opportunities
Authors: Kalueff A. V. , Kotova M. M. , Ikrin A. N. , Kolesnikova T. O. 
Published: September 2023

Scientific relevance. Since fiscal and regulatory constraints substantially limit bioscreening in rodent models, a wider implementation of additional alternative models in preclinical studies of medicines is gaining momentum. These alternative models include aquatic vertebrates, such as zebrafish (Danio rerio).Aim.The study aimed to examine zebrafish models in terms of their performance in preclinical studies, their current uses, the challenges and opportunities in the field, and strategic directions for the development of preclinical testing in zebrafish.Discussion.Here, the authors summarise the key zebrafish tests that are currently used to assess a wide range of small molecules for their general and endocrine toxicity and effects on the survival of embryos and larvae. The review discusses the strengths and weaknesses of zebrafish models for preclinical testing of neurotropic agents. Additionally, the authors overview various methodological approaches to improving zebrafish toxicity testing. Overall, the use of zebrafish models is gradually becoming internationally established for laboratory testing of small molecules.Conclusions.A wider implementation of zebrafish models in pharmaceutical research and preclinical testing as an additional alternative to rodents, particularly in Russia, may significantly accelerate the development of novel medicinal products and foster a more comprehensive and adequate assessment of the biological risks associated with chemical substances.
Current Approaches to the Preclinical Assessment of Endocrine Toxicity
Authors: Babkov D. A. 
Published: September 2023

Scientific relevance. Endocrine disruptors affect the functioning of endocrine organs, which leads to adverse drug reactions. Endocrine toxicity requires special attention in preclinical studies of candidate medicinal products.Aim. The study aimed to review international guidelines and approaches to assessing the risk of endocrine toxicity associated with medicinal products.Discussion. This review covers documents that provide a methodological framework for identifying and classifying a chemical compound as an endocrine disruptor. These documents include the following: Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption (Organisation for Economic Cooperation and Development, 2018), Nonclinical Evaluation of Endocrine-Related Drug Toxicity (Food and Drug Administration, 2015), and Guidance for the Identification of Endocrine Disruptors in the Context of Regulations (EU) No. 528/2012 and (EC) No. 1107/2009. The proposed algorithm for endocrine toxicity assessment involves collecting all available data on the test compound, such as the literature and previously obtained experimental data, including acute and subchronic toxicity data, and in silico predictions. Particular attention should be paid to the standard battery of preclinical chronic toxicity studies, which can identify most side effects associated with the endocrine system. The main endpoints for endocrine toxicity include changes in the mass and histopathology of the major endocrine organs (adrenal glands, testes, epididymides, ovaries, and the thyroid gland), oestrous cycle effects, reproductive toxicity, and transplacental action. A thorough assessment of the data obtained provides for the determination of unfavourable endocrine activity that requires further studies.Conclusions. The OECD guidelines offer a set of validated in vivo and in vitro tests that characterise the most important mechanisms of endocrine toxicity (oestrogen, androgen, thyroid, and steroidogenic endocrine pathways) by identified toxic effects. This approach allows researchers to identify potential endocrine disorders early in the drug development process and to optimise the scope of the required studies accordingly.
INDONESIAN TRADITIONAL GAME «BANDHUL SADA» IN LEARNING ROTATION DYNAMIC CONCEPTS WITH CONTEXTUAL APPROACH
Authors: Fatmaryanti Siska Desy 
Published: September 2023

Teachers can support cultural preservation while also providing a relevant and interesting way to teaching diverse subjects by including traditional games into the learning process. The aim of this research is identify the rotation dynamic concepts of Indonesian traditional game «Bandhul Sada» with contextual approach
Formulation of the problem. We focused how to learn the rotational dynamic concept with traditional game «Bandhul Sada» and implementation learning steps with contextual approach.This identification includes analysis of rotation dynamic consepts in “Bandhul Sada” and analysis of learning steps with a contextual approach to the application of the game.
Materials and methods. The method used qualitative approach with descriptive analysis. In the analysis of rotation dynamic concepts and learning step in contextual approach, we used the method of narrative review research. Literature and observation have been used as the data collection methods. In the analysis of learning step, we used the literature review includes gathering information through literature that supports the development of learning steps based on a contextual approach.
Results. Result of the research shows that (1) in «Bandhul Sada» game can be explained the concept of rotation dynamics that occur, namely linear speed, angular velocity, and angular momentum; (2) this game can be applicate in learning with contextual approach. This learning consist of 5 phase. There were constructing knowledge possessed by students, developing students' initial knowledge, using game «Bandhul Sada» in delivering material concepts, conducting inquiry processes through discussion activities and finally reflection. From all these learning phases, it appears that there is a relationship between teaching approaches and achievement of goals.
Conclusions. Thus it can be concluded that the traditional game «Bandhul Sada» can be used as a real example in learning physics the concept of rotational dynamics such as angular velocity and linear velocity. And it provides students with valuable experience in constructing their own knowledge in a variety of methods.
Geochemical features of organic matter in the Lower Cretaceous deposits of the Ozhoginskaya Suite (Indigiro-Zyryansky basin)
Authors: Zueva I. N. , Chalaya O. N. , Kashirtsev V. A. , Glyaznetsova Yu. S. , Lifshits S. Kh. 
Published: September 2023

Limited available data on molecular geochemistry indicate the predominance of terragenous organic matter in the source material of the Lower Cretaceous deposits of the Ozhoginskaya suite, which allows it to be considered gasgenerating. However, based on the mixed nature of the source material, this suite could possess potential for liquid hydrocarbon generation. The geochemical features of the organic matter were studied using classical bituminology, Fourier transform infrared spectroscopy, gas chromatography, and mass spectrometry. The results showed a regular distribution of alkanes with a predominance of low-molecular-weight homologues with a maximum at nC15-19 and low values of ∑n.c.-nC20/∑nC21-c.c., vanadylporphyrin complexes. Thus, the contribution of algal material could be significant to the composition of the fossil organic matter of the Lower Cretaceous Ozhoginsky suite with different ratios of terrigenous and aquatic components in the section. Our results on the Ozhoginskaya suite showed the similarity of geochemical parameters with the Upper Bastakh suite of the Upper Jurassic, the features of bitumoid composition, which were mainly due to the predominance of planktonic-algal material capable of generating a large amount of liquid hydrocarbons. This established similarity raises the estimate of the oil generation potential of the organic matter of the Lower Cretaceous deposits of the Ozhoginskaya suite, along with the high gas generation potential inherent in terragenous organic matter.
Identification of thermal anomalies in Yakutsk using satellite data
Authors: Struchkova G. P. , Krupnova T. G. , Rakova O. V. , Tikhonova S. A. , Shein N. S. , Kapitonova T. A. 
Published: September 2023

Thermal anomalies in the city, otherwise called “heat islands, “are formed under the influence of anthropogenic factors. In Yakutsk, temperature anomalies were caused by GRES-1, GRES-2, and other industrial complexes. The crowding of residential buildings and structures prevents the movement of air masses and makes it impossible to maintain the condition of the cryolithozone at the proper level, which contributes to the degradation of permafrost in a warming climate. We propose to didentify “heat islands” in Yakutsk using remote sensing methods, based on the data of the thermal infrared range of the Landsat 8 satellite, which provides information with an interval of 16 days. The thermal anomalies in various areas of Yakutsk and its vicinity in summer and winter, which create zones of possible permafrost degradation and affect the geocryological safety of the city, were analyzed based on the proposed methodology. This information will make it possible to monitor the process of changes in the temperature field of a territory and implement preventive measures for the stability of buildings and structures.
Biomonitoring of the environment of the Arctic urbanized area using the pollen of Sorbus gorodkovii Pojark
Authors: Vasilevskaya N. V. , Sikalyuk A. I. 
Published: September 2023

This article investigates the content of heavy metals (Cu, Ni, V, Cd, Zn) in the reproductive organs of the Gorodkov’s rowan (Sorbus gorodkovii Pojark.) growing in the impact zone of environmentally hazardous facilities in Murmansk (CHP plants, waste incineration plant and trade sea port). The samples most contaminated by heavy metals were registered in the vicinity of the incineration plant. High concentrations of vanadium (4,2–4,8 mg/kg) and Cu, Ni, Cd, and Zn exceeding the limits of MPC are revealed in the impact zone of CHP plants operating on fuel oil. Biomonitoring of the viability of S. gorodkovii pollen showed that in all samples, the content of fertile pollen grains was reduced compared to that in the control. At the test sites of the Central and South CHP plants, the proportion of fertile pollen was 35–41 % (compared to 72 % in the control sample). The induced sterility was more than two times higher than the spontaneous sterility. High concentrations of vanadium and other toxic metals in emissions of Heating Plants have a gametocidal effect on the male gametophyte of S. gorodkovii. Groups of fertile and sterile pollen grains were selected according to their size: dwarf, normal, or hypertrophied. In the vicinity of the CHP plants, the proportion of fertile pollen of normal size decreased (62–69 %), whereas the content of dwarf (16–18 %) and hypertrophic pollen (17.4–22.7 %) increased. Sterile pollen grains were mostly dwarf (63–70 %). The results of biomonitoring indicated that CHP plants polluted the urban environment with vanadium and other toxic metals, which caused sterilization of S. gorodkovii male gametes. To improve the ecological situation in Murmansk, it is necessary to switch the thermal stations for the use of natural gas.
Data on hunting use of waterfowl resources in Yakutia
Authors: Solokha A. V. , Blokhin Yu. Yu. 
Published: September 2023

Scientific information on waterfowl harvesting in Yakutia is mostly outdated. The lack of reliable bag data prevents the establishment of sustainable use of waterfowl resources under the conditions of massive shooting and a modified legislation base. This research aimed to collect and analyze contemporary information on the hunting take of waterfowl (Anatidae, Coot, loons, and grebes) in Yakutia. We used data from the State Hunting Registry (2017–2022) to estimate the total harvest. Species-specific shares in hunting bags were identified using digital photographs of shot birds collected from the Internet in 2015, 2017, and 2018 (around 1000 photos). The distribution and results of traditional spring hunting of scoters were studied through a survey of hunters conducted in 2015. On average, 18,400 geese and 200,000 ducks were shot during the summer-autumn season, whereas 26,600 geese and 160,500 ducks were shot during the spring season. Overall, 23 waterfowl species were identified, namely three species of geese, 17 species of ducks, Coot, Arctic Loon, and Red-necked Grebe. The autumn bag included 22 species, of which the bean goose, mallard, Eurasian wigeon, and common teal were the most abundant. Spring bags consisted of 14 species with prevailing bean geese, common teals, northern pintails, and mallards. Based on “least concern” international and national conservation status we suggest to exclude the Chinese Spot-billed Duck, Gadwall, Common Scoter and Coot from the Red Data Book of the Republic of Sakha (Yakutia) and resume their hunting use.
Post-fire reforestation of pine forests adjacent to the tukulans of the Lena-Vilyui interfluve
Authors: Gabysheva L. P. 
Published: September 2023

This article presents the results of forestry and geobotanical studies of post-fire communities in pine forests adjacent to large sandy deserts, tukulans, in the Lena-Vilyui interfluve. Pine forests, which are widespread in the middle and around the tukulans, have recently become highly susceptible to fires, as the entire territory of the Lena-Vilyui interfluve. In 2019, we collected materials on post-fire communities in multi-age burned areas, which supplement a few pieces of information regarding post-fire reforestation. We found that the vast areas of the studied region were occupied by pyrogenic communities. We assumed that the natural regeneration of Scotch pine in the vicinity of tukulans was unsatisfactory, with 0.3–0.95 thousand pieces of pine undergrowth/ha. Post-fire communities can become launching pads for the development of modern aeolian processes or can expand the area of existing tukulans.