bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients
Authors: Gao Chen , Peng Longkai 
Published: March 2023

AimThe progression of acute kidney injury (AKI) might be associated with systemic inflammation. Our study aims to explore the association and predictive value of the red blood cell distribution width (RDW) to human serum albumin (ALB) ratio (RDW/ALB ratio), an inflammation-related indicator, in the risk of all-cause mortality and renal replacement therapy (RRT) in AKI patients admitted in intensive care units (ICU).MethodsA retrospective cohort study was designed, and data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III). The primary outcome was the risk of all-cause mortality (1-month, 3-month, and 12-month), and the secondary outcome was the risk of RRT. The association between the RDW/ALB ratio and the risk of all-cause mortality and RRT was assessed using the Cox regression analysis, with results shown as hazard ratio (HR) and 95% confidence intervals (CIs). The relationship between the RDW/ALB ratio and crude probability of all-cause mortality or RRT was assessed using restricted cubic splines (RCS). The concordance index (C-index) was used to assess the discrimination of the prediction model.ResultsA total of 13,856 patients were included in our study. In the fully adjusted Cox regression model, we found that a high RDW/ALB ratio was associated with an increased risk of 1-month, 3-month, and 12-month all-cause mortality and RRT (all p &lt; 0.05). Moreover, RCS curves showed the linear relationship between the RDW/ALB ratio and the probability of all-cause mortality and RRT, and the probability was elevated with the increase of the ratio. In addition, the RDW/ALB ratio showed a good predictive performance in the risk of 1-month all-cause mortality, 3-month all-cause mortality, 12-month all-cause mortality, and RRT, with a C-index of 0.728 (95%CI: 0.719–0.737), 0.728 (95%CI: 0.721–0.735), 0.719 (95%CI: 0.713–0.725), and 0.883 (95%CI: 0.876–0.890), respectively.ConclusionThe RDW/ALB ratio performed well to predict the risk of all-cause mortality and RRT in critically ill patients with AKI, indicating that this combined inflammatory indicator might be effective in clinical practice.
The increased antioxidant action of HDL is independent of HDL cholesterol plasma levels in triple-negative breast cancer
Authors: Campos Amarilis de Lima , Sawada Maria Isabela Bloise Alves Caldas , Santana Monique Fátima de Mello , Iborra Rodrigo Tallada , de Assis Sayonara Ivana Santos , Reis Mozania , de Carvalho Jacira Xavier , Gebrim Luiz Henrique , Passarelli Marisa 
Published: March 2023

IntroductionThe association between high-density lipoprotein cholesterol (HDLc) with the incidence and progression of breast cancer (BC) is controversial. HDL removes excess cholesterol from cells and acts as an antioxidant and anti-inflammatory. BC is a heterogeneous disease, and its molecular classification is important in the prediction of clinical and therapeutic evolution. Triple-negative breast cancer (TNBC) presents higher malignancy, lower therapeutic response, and survival rate. In the present investigation, the composition and antioxidant activity of isolated HDL was assessed in women with TNBC compared to controls.MethodsTwenty-seven women with a recent diagnosis of TNBC, without prior treatment, and 27 healthy women (control group) paired by age and body mass index (BMI) were included in the study. HDL and low-density lipoprotein (LDL) were isolated from plasma by discontinuous density gradient ultracentrifugation. Plasma lipid profile and HDL composition (total cholesterol, TC; triglycerides, TG; HDLc; phospholipids, PL) were determined by enzymatic colorimetric methods. ApoB and apo A-I were quantified by immunoturbidimetry. The antioxidant activity of HDL was determined by measuring the lag time phase for LDL oxidation and the maximal rate of conjugated dienes formation in LDL incubated with copper sulfate solution. The absorbance (234 nm) was monitored at 37°C, for 4 h, at 3 min intervals.ResultsThe control group was similar to the TNBC concerning menopausal status, concentrations, and ratios of plasma lipids. The composition of the HDL particle in TC, TG, PL, and apo A-I was also similar between the groups. The ability of HDL to retard LDL oxidation was 22% greater in the TNBC group as compared to the control and positively correlated with apoA-I in HDL. Moreover, the antioxidant activity of HDL was greater in the advanced stages of TNBC (stages III and IV) compared to the control group. The maximum rate of formation of conjugated dienes was similar between groups and the clinical stages of the disease.DiscussionThe results highlight the role of HDL as an antioxidant defense in TNBC independently of HDLc plasma levels. The improved antioxidant activity of HDL, reflected by retardation in LDL oxidation, could contribute to limiting oxidative and inflammatory stress in advanced stages of TNBC.
The repeatability and consistency of different methods for measuring the volume parameters of the primary rectal cancer on diffusion weighted images
Authors: Qiu Yong-juan , Zhou Lin-Li , Li Jun , Zhang Yi-fei , Wang Yong , Yang Yan-song 
Published: March 2023

BackgroundTo determine the reproducibility of measuring the gross total volume (GTV) of primary rectal tumor with manual and semi-automatic delineation on the diffusion-weighted image (DWI), examine the consistency of using the same delineation method on DWI images with different high b-values, and find the optimal delineation method to measure the GTV of rectal cancer.Methods41 patients who completed rectal MR examinations in our hospital from January 2020 to June 2020 were prospectively enrolled in this study. The post-operative pathology confirmed the lesions were rectal adenocarcinoma. The patients included 28 males and 13 females, with an average age of (63.3 ± 10.6) years old. Two radiologists used LIFEx software to manually delineate the lesion layer by layer on the DWI images (b=1000 s/mm2 and 1500 s/mm2) and used 10% to 90% of the highest signal intensity as thresholds to semi-automatically delineate the lesion and measure the GTV. After one month, Radiologist 1 performed the same delineation work again to obtain the corresponding GTV.ResultsThe inter- and intra-observer interclass correlation coefficients (ICC) of measuring GTV using semi-automatic delineation with 30% to 90% as thresholds were all &gt;0.900. There was a positive correlation between manual delineation and semi-automatic delineation with 10% to 50% thresholds (P &lt; 0.05). However, the manual delineation was not correlated with the semi-automatic delineation with 60%, 70%, 80%, and 90% thresholds. On the DWI images with b=1000 s/mm2 and 1500 s/mm2, the 95% limit of agreement (LOA%) of measuring GTV using semi-automatic delineation with 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, and 90% thresholds were -41.2~67.4, -17.8~51.5, -16.1~49.3, -26.2~50.1, -42.3~57.6, -57.1~65.4, -67.3~66.5, -101.6~91.1, -129.4~136.0, and -15.3~33.0, respectively. The time required for GTV measurement by semi-automatic delineation was significantly shorter than that of manual delineation (12.9 ± 3.6s vs 40.2 ± 13.1s).ConclusionsThe semi-automatic delineation of rectal cancer GTV with 30% threshold had high repeatability and consistency, and it was positively correlated with the GTV measured by manual delineation. Therefore, the semi-automatic delineation with 30% threshold could be a simple and feasible method for measuring rectal cancer GTV.
Berberine regulates glucose metabolism in largemouth bass by modulating intestinal microbiota
Authors: Xia Yun , Yang Hui-Ci , Zhang Kai , Tian Jing-Jing , Li Zhi-Fei , Yu Er-Meng , Li Hong-Yan , Gong Wang-Bao , Xie Wen-Ping , Wang Guang-Jun , Xie Jun 
Published: March 2023

This study examined the role of intestinal microbiota in berberine (BBR)-mediated glucose (GLU) metabolism regulation in largemouth bass. Four groups of largemouth bass (133.7 ± 1.43 g) were fed with control diet, BBR (1 g/kg feed) supplemented diet, antibiotic (ATB, 0.9 g/kg feed) supplemented diet and BBR + ATB (1g/kg feed +0.9 g/kg feed) supplemented diet for 50 days. BBR improved growth, decreased the hepatosomatic and visceral weight indices, significantly downregulated the serum total cholesterol and GLU levels, and significantly upregulated the serum total bile acid (TBA) levels. The hepatic hexokinase, pyruvate kinase, GLU-6-phosphatase and glutamic oxalacetic transaminase activities in the largemouth bass were significantly upregulated when compared with those in the control group. The ATB group exhibited significantly decreased final bodyweight, weight gain, specific growth rates and serum TBA levels, and significantly increased hepatosomatic and viscera weight indices, hepatic phosphoenolpyruvate carboxykinase, phosphofructokinase, and pyruvate carboxylase activities, and serum GLU levels. Meanwhile, the BBR + ATB group exhibited significantly decreased final weight, weight gain and specific growth rates, and TBA levels and significantly increased hepatosomatic and viscera weight indices and GLU levels. High-throughput sequencing revealed that compared with those in the control group, the Chao one index and Bacteroidota contents were significantly upregulated and the Firmicutes contents were downregulated in the BBR group. Additionally, the Shannon and Simpson indices and Bacteroidota levels were significantly downregulated, whereas the Firmicutes levels were significantly upregulated in ATB and BBR + ATB groups. The results of in-vitro culture of intestinal microbiota revealed that BBR significantly increased the number of culturable bacteria. The characteristic bacterium in the BBR group was Enterobacter cloacae. Biochemical identification analysis revealed that E. cloacae metabolizes carbohydrates. The size and degree of vacuolation of the hepatocytes in the control, ATB, and ATB + BBR groups were higher than those in the BBR group. Additionally, BBR decreased the number of nuclei at the edges and the distribution of lipids in the liver tissue. Collectively, BBR reduced the blood GLU level and improved GLU metabolism in largemouth bass. Comparative analysis of experiments with ATB and BBR supplementation revealed that BBR regulated GLU metabolism in largemouth bass by modulating intestinal microbiota.
BrUFO positively regulates the infection of Chinese cabbage by Plasmodiophora brassicae
Authors: Zhang Bo , Feng Hui , Ge Wenjie , Wang Xinlei , Zhang Jing , Ji Ruiqin 
Published: March 2023

IntroductionChinese cabbage is one of the most important vegetable crops in China. However, the clubroot disease caused by the infection of Plasmodiophora brassicae (P. brassicae) has seriously affected the yield and quality of Chinese cabbage. In our previous study, BrUFO gene was found to be significantly up-regulated in diseased roots of Chinese cabbage after inoculation with P. brassicae. UFO (UNUSUAL FLORAL ORGANS) have the properties of substrate recognition during ubiquitin-mediated proteolysis. A variety of plant can activate immunity response through the ubiquitination pathway. Therefore, it is very important to study the function of UFO in response to P. brassicae.MethodsIn this study, The expression pattern of BrUFO Gene was measured by qRT-PCR and In situ Hybridization (ISH). The expression location of BrUFO in cells was determined by subcellular localization. The function of BrUFO was verified by Virus-induced Gene Silencing (VIGS). proteins interacting with BrUFO protein were screened by yeast two-hybrid.ResultsQuantitative real-time polymerase chain reactions (qRT-PCR) and in situ hybridization analysis showed that expression of BrUFO gene in the resistant plants was lower than that in susceptible plants. Subcellular localization analysis showed that BrUFO gene was expressed in the nucleus. Virus-induced gene silencing (VIGS) analysis showed that silencing of BrUFO gene reduced the incidence of clubroot disease. Six proteins interacting with BrUFO protein were screened by Y2H assay. Two of them (Bra038955, a B-cell receptor-associated 31-like protein and Bra021273, a GDSL-motif esterase/acyltransferase/lipase Enzyme) were confirmed to strongly interact with BrUFO protein.DiscussionBrUFO gene should be a key gene of chinese cabbage against the infection of P. brassicae. BrUFO gene silencing improves the resistance of plants to clubroot disease. BrUFO protein may interact with CUS2 to induce ubiquitination in PRR-mediated PTI reaction through GDSL lipases, so as to achieve the effect of Chinese cabbage against the infection of P. brassicae.
Brief moderate-intensity aerobic exercise improves the executive function of Chinese undergraduates regardless of mobile phone addiction: Evidence from the antisaccade task
Authors: Zhou Junyi , Bai Zhanshuang 
Published: March 2023

IntroductionPrevious studies have shown that brief moderate-intensity aerobic exercise can improve the executive function of healthy adults. The present study sought to examine and compare the effects of brief moderate-intensity aerobic exercise on the executive functions of undergraduates with and without mobile phone addiction.MethodThirty-two healthy undergraduates with mobile phone addiction were recruited and randomly assigned to either an exercise or control group. Likewise, 32 healthy undergraduates without mobile phone addiction were recruited and randomly assigned to either an exercise or control group. Participants were asked to perform moderate-intensity aerobic exercise for 15 minutes for the exercise groups. The executive functions of all participants were assessed via the antisaccade task twice (i.e., pre-test and post-test).ResultsThe results showed that the saccade latency, variability of saccade latency, and error rate decreased significantly from pre-test to post-test for all participants. More importantly, after the 15-min moderate-intensity aerobic exercise intervention, participants in the exercise groups showed significantly shorter saccade latency than their counterparts in the control groups, regardless of whether they are with mobile phone addiction.DiscussionThis result is consistent with previous studies demonstrating that brief moderate-intensity aerobic exercise can improve one’s executive function. Furthermore, the absence of significant interaction among Time, Group, and Intervention implies that the effects of brief moderate-intensity aerobic exercise on executive function are comparable between participants with and without mobile phone addiction. The present study supports the previous conclusion that brief moderate-intensity aerobic exercise can improve one’s executive function effectively, and extends it to the population with mobile phone addiction. In summary, the present study has some implications for understanding of the relationship between exercise, executive function, and mobile phone addiction.
Evaluating primary care transformation: synthesis of findings from UK pilot project reviews
Authors: McSwiggan Emilie , Ng Lauren , Donaghy Eddie , Huang Huayi , Gillies John , Henderson David AG , Thompson Andrew , Wang Harry HX , Mercer Stewart W 
Published: March 2023

BackgroundPilot 'new models' of primary care have been funded across the UK since 2015, through various national transformation funds. Reflections and syntheses of evaluation findings provide an additional layer of insight into 'what works' in transforming primary care.AimTo identify good practice in policy design, implementation, and evaluation for primary care transformation.Design & settingA thematic analysis of existing pilot evaluations in England, Wales, and Scotland.MethodTen studies presenting evaluations of three national pilot studies — the Vanguard programme in England, the Pacesetter programme in Wales, and the National Evaluation of New Models of Primary Care in Scotland — were thematically analysed, and findings synthesised in order to identify lessons learnt and good practice.ResultsCommon themes emerged across studies in all three countries at project and policy level, which can support or inhibit new models of care. At project level, these included the following: working with all stakeholders, including communities and front-line staff; providing the time, space, and support necessary for the project to succeed; agreeing on clear objectives from the outset; and support for data collection, evaluation, and shared learning. At policy level, more fundamental challenges related to the parameters for pilot projects, in particular, the typically short-term nature of funding, with an expectation of results within 2–3 years. Changing expectations about outcome measures or project guidance part-way through project implementation was also identified as a key challenge.ConclusionPrimary care transformation requires coproduction and a rich, contextual understanding of local needs and complexities. However, a mismatch between policy objectives (care redesign to better meet patient needs) and policy parameters (short timeframes) is often a significant challenge to success.
DETERMINISTIC FINITE STATE MACHINE FOR SEARCH OF CONTAINERS IN STACK
Authors: Malikova T. , Solov'eva E. , Radochinskaya A. 
Published: March 2023

This paper considers the prospects of digitalization in the warehouse cargo handlingsystem, as well as the
impact of modern IT technologies on the logistics of a sea container terminal. The technological process of
container transshipment in the operational areas of the terminal and formation of auxiliary stacks for further
transfer of cargo between different transport means, their temporary storage and transformation (from containerized
form to general cargo and back), as well as the implementation of secondary operations (checking,
weighing, etc.) are the object of research. From an operational point of view, the formation of an auxiliary stack
is a time-taking technological operation, as it requires the selective search and withdrawal from the general
stack of a certain number of containers that make up the logistic flow of cargo moved to the relevant operational
zone. The method of research is automatic programming of the simulated technological process. In this case,
the simulation object is described by a finite automaton which is then converted into code. The main purpose
of the automaton is to implement the control function. In the context of this research work, the control actions
are aimed at the reloader and program the sequence of its actions to find the target containers in the stack. A
mathematical model of the search and withdrawal of the target containers from the stack in the terminal storage
area by means of a computerized control system, as well as a transition graph of the finite automaton with
control rules (codes) are the results of this research. The application of above mathematical facility to modeling
of technological processes makes it possible to present a unified logic of management of the prestacking process
in operational areas of the terminal
Moult strategies of White Wagtail Motacilla alba and Yellow Wagtail Motacilla flava in central Sweden
Authors: Sondell Jan 
Published: March 2023

The wing moult of the White Wagtail Motacilla a. alba and the Yellow Wagtail M. f .flava has been recorded since 1973 at Kvismaren, central Sweden. Based on data from 558 White and 78 Yellow Wagtails in active moult the wing moult duration of the former was estimated at 55–65 days and of the latter at 35–40 days. The moult sequence was the same in both species. The only significant difference was the speed of the moult. The reason for this difference in moult strategy is probably the difference in migration destination of the two species. The Yellow Wagtail arrives later than the White Wagtail, stays a shorter time in central Sweden and starts the migration towards tropical Africa just before finishing the moult in the middle of August. Swedish White Wagtails winter in the east Mediterranean, arrive almost a month earlier and leave a month later. It is difficult to compare the present results with data from other parts of Europe as there are plenty of misrepresentations published some decades ago and quoted in later works. Therefore, methods of moult data evaluation are also briefly discussed.
Cytotoxic Activity Test Of Ethanolic Extract Of Berenuk Fruit (Crescentia Cujete L.) On Artemia Salina Leach Shrimp Larva Using Brine Shrimp Lethality Test (BSLT) Method
Authors: Suzana Dona , Handayanti Isnani 
Published: March 2023

Abstract: Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy which has cytotoxic effects. One of the plants that have the same effect is berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae, which grows wild and is often referred to as a poisonous plant. This plant contains napthoquinone as one of cytotoxic chemical compounds and other metabolite secondary such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. The objective of this study is to determine the cytotoxic activity of ethanolic extract of the fruit of berenuk on Artemia salina Leach larva. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larva that has been prepared and the value of mortality was observed. The result of cytotoxic activity test of ethanolic extract of berenuk fruit on A. salina larva had the LC50 value of 529.386 ppm which is categorized as toxic.
Evaluasi Pengobatan Yang Diterima Anak Berkebutuhan Khusus Di Sumatera Selatan, Indonesia
Authors: Ramatillah Diana Laila , Dinli Dwi Yunisa , Ipadeola Mairo Hamid , Rabima Rabima , Paulina Ida , Rofii Ahmad 
Published: March 2023

ABSTRAK
Anak berkebutuhan khusus merupakan anak dengan karakteristik yang berbeda dengan anak pada umumnya yang secara signifikan mengalami kelainan (mental-intelektual, fisik, sosial dan emosi). Penelitian ini bertujuan untuk mengevaluasi pengobatan yang diterima anak-anak berkebutuhan khusus di Sumatera Selatan. Ini adalah survei cross-sectional yang dilakukan dikalangan siswa/siswi di SLB Sumatera Selatan dengan menggunakan kuesioner yang dikelola sendiri. Teknik pengambilan sampel dilakukan dengan convenience sampling. Dari hasil penelitian ini diketahui, laki-laki 53 orang dan perempuan 43 orang. Berdasarkan hasil penelitian didapatkan bahwa pengobatan yang diterima oleh anak berkebutuhan khusus yaitu DHA (Omega-3) + Vitamin B Complex sebanyak 20 orang (37%) sebesar 20% dipengaruhi oleh sebagian besar yang mengkonsumsi pengobatan pada usia 11-15 tahun. Terdapat hubungan yang signifikan antara pengobatan dengan tingkat kecerdasan yang ditandai dengan p-value 0.02, yang menunjukan bahwa sebanyak 7 orang (7%) baik dan sedang sebanyak 89 orang (93%). Diketahui juga, ada hubungan yang signifikan antara penyakit penyerta dengan pengobatan ditandai dengan p-value (P < 0.001), dimana diketahui epilepsy sebanyak 35 orang (37%), dan tidak memiliki penyakit penyerta sebanyak 61 orang (63%). DHA (Omega-3) adalah suplemen yang paling banyak diberikan kepada siswa/siswi berkebutuhan khusus pada usia 11-15, dan hanya sedikit siswa yang menerima Dapakote (Divalproex Sodium) dan multivitamin termasuk Vitamin A, B kompleks dan Vitamin C dengan rata-rata tingkat kecerdasan sedang. Hal ini dipengaruhi oleh penyakit penyerta seperti epilepsy.

Kata kunci: ABK; Pengobatan; Perkembangan; Variabel Demografi