bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concerns Regarding the Use of Kirchhoff’s Laws in Pharmacokinetics
Authors: Øie Svein 
Published: January 2025

Abstract
Over the last two years the idea that the principles presented in Kirchhoff’s circuit and voltage laws also pertain to pharmacokinetics (1–3). It is claimed that these principles make the elimination in the liver and kidney more straight forward to model and provide a rationale for understanding why sometimes during bioavailability studies one arrives at bioavailability values greater than 100%. In this paper it will be shown that these claims are based on incorrect translations of the Kirchhoff’s Laws to pharmacokinetics.
Bode gain-phase relation beyond the minimum phase condition
Authors: Prevedelli M. , Perinelli A. , Ricci L. 
Published: January 2025

Abstract
The Bode gain-phase relation links the phase shift introduced by a causal, linear and time-invariant system with its frequency-dependent magnitude gain. The relation, which is widely used in system theory and electronics, was first derived by H. W. Bode for a transfer function described, in the Fourier (Laplace) domain, by rational functions of frequency, where the numerator fulfills the so-called minimum-phase condition, according to which the polynomial numerator of the frequency-domain transfer function has no zeroes in the upper-half (right-half) of the complex ω-plane (s-plane). Here we discuss a general derivation that widens the range of applicability of the relation beyond the minimum phase condition, allowing the presence of zeroes and encompassing cases in which delays occur. Both these features are widely present in real physical systems, thus endowing the new proof with a broader range of validity.
Collective and non-collective states in
Authors: Gupta A. K. , Sharma H. P. , Rana A. K. , Anser M. , Sharma Ishika , Tiwary S. S. , Chakraborty S. , Majumder C. , Sharma Anupriya , Pandey Anand , Anuj  , Chamoli S. K. , Kumar S. , Katre Kaushik , Muralithar S. , Singh R. P. , Yashraj  , Bala Indu , Mukherjee Arunita , Bhattacharya Sutanu , Trivedi T. , Mozumdar Nikhil , Banerjee P. , Subodh  , Kumar A. 
Published: January 2025

Abstract
The high spin states of 136Ce (Z = 58) were investigated via 124Sn(16O, 4n)136Ce fusion evaporation reaction at

MeV. The γ-γ coincidence technique is used for placing the γ-transitions in the level scheme. The spin and parity of the levels have been assigned on the basis of results of the angular correlation and linear polarisation measurements, respectively. The bands based on the yrast

10+ isomeric state and the non-yrast

10+ state have been established. The structures of these bands are also compared with the band structures of the neighbouring nuclei.
KCNJ5 Somatic Mutations are Associated with Better Long-Term Outcomes in Patients with Unilateral Primary Aldosteronism
Authors: Chan Chieh-Kai , Yang Wei-Shiung , Lin Yen-Hung , Chang Chin-Cheng , Wu Vin-Cent , Chueh Jeff S 
Published: January 2025

Abstract

Context
The association between KCNJ5 somatic mutations and long-term outcomes in patients with operated unilateral primary aldosteronism (uPA) is unclear.

Objective
To evaluate associations among KCNJ5 somatic mutations, clinical characteristics, incident long-term cardiovascular events, and all-cause mortality in uPA patients after adrenalectomy in a large longitudinal population study.

Methods
We enrolled uPA patients from the Taiwan Primary Aldosteronism Investigation database who had undergone adrenalectomy between 2013 and 2017 and followed them until 2020. The outcomes were achieving complete clinical success at 1 year after adrenalectomy, long-term major adverse cardiac and cerebrovascular events (MACCEs), and mortality.

Results
Of the 358 enrolled patients (46.7% men; mean age, 51.3 years), 188 (52.5%) harbored KCNJ5 somatic mutations. The baseline characteristics of younger age [odds ratio (OR)=2.44; P=0.001], lower body mass index (OR=2.04; P=0.005), lower potassium (OR=6.55; P&lt;0.001), and larger tumor size (OR=2.05; P=0.023) were potential predictors of KCNJ5 somatic mutations. The operated uPA patients harboring KCNJ5 somatic mutations were associated with a higher likelihood of complete clinical success at 1 year after adrenalectomy (OR=1.98; P=0.016). KCNJ5 somatic mutation carriers [hazard ratio (HR)=0.46; P=0.044), those with a shorter duration of hypertension (HR=1.05; P=0.008), and those who achieved complete clinical success (HR=0.49; P=0.036) had a lower risk of MACCEs and mortality.

Conclusion
Operated uPA patients harboring KCNJ5 somatic mutations had a lower risk of long-term MACCEs and mortality after adrenalectomy. However, better long-term outcomes in the operated uPA patients harboring KCNJ5 somatic mutations were attenuated in those with baseline lower potassium levels, shorter duration of hypertension, obesity, higher estimated glomerular filtration rate, and residual hypertension after adrenalectomy.
Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity
Authors: Anjom-Shoae Javad , Fitzgerald Penelope C E , Horowitz Michael , Holst Jens J , Rehfeld Jens F , Veedfald Simon , Feinle-Bisset Christine 
Published: January 2025

Abstract

Context
In males of normal weight, intraduodenal administration of calcium enhances the effects of the amino acid L-tryptophan (Trp) to suppress energy intake, associated with greater stimulation of cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), and peptide tyrosine-tyrosine (PYY) secretion (key mechanisms underlying the regulation of pyloric motility and gastric emptying) but not gastrin or glucose-dependent insulinotropic polypeptide (GIP).

Objective
Given the implications for the management of obesity, the current study evaluated the effects of calcium, when administered alone and in combination with Trp, on gut hormone secretion, antropyloroduodenal motility, and energy intake in males with obesity.

Methods
Fifteen males with obesity and without type 2 diabetes (mean ± SD; age: 27 ± 8 years; body mass index: 30 ± 2 kg/m2; hemoglobin A1c: 5.3 ± 0.2%), received 150-minute intraduodenal infusions of 0, 500, or 1000 mg calcium, each combined with Trp (load: 0.1 kcal/min, known to have submaximal energy-intake suppressant effects) from t = 75-150 minutes, on 3 separate occasions, in a randomized, double-blind, cross-over order. Plasma concentrations of gastrin, CCK, GIP, GLP-1, PYY, and pyloric pressures were measured during the infusions. Immediately postinfusion (t = 150-180 minutes), energy intake at a standardized buffet-style lunch was quantified.

Results
Calcium, in a dose of 1000 mg, stimulated GLP-1, PYY, and pyloric pressures alone (all P &lt; .05) and enhanced the effects of Trp to stimulate CCK, GLP-1, and PYY (all P &lt; .05), associated with greater suppression of energy intake (P = .01). Energy intake (R = −0.64; P = .001) was inversely related to the dose of calcium, while plasma concentrations of CCK (R = 0.44; P = .05), GLP-1 (R = 0.60; P = .01), and PYY (R = 0.83; P = .01) were directly related.

Conclusion
Intraduodenal calcium enhances the effect of intraduodenal Trp to stimulate CCK, GLP-1, and PYY and suppress energy intake in males with obesity.
Rab10 function in tubular endosome formation requires the N-terminal K3 residue and is disrupted by N-terminal tagging
Authors: Hata Rinka , Sugawara Akira , Fukuda Mitsunori 
Published: January 2025

ABSTRACT
Various N-terminal tags have often been used to identify the functions and localization of Rab small GTPases, but their impact on Rab proteins themselves has been poorly investigated. Here, we used a knockout (KO)–rescue approach to systematically evaluate the effect of N-terminal tagging of two Rabs, Rab10 and Rab27A, on RAB10-KO HeLa cells and Rab27A-deficient melanocytes (melan-ash cells), respectively. The results showed that all of the N-terminal-tagged Rab27A proteins mediated actin-based melanosome transport in the melan-ash cells, but none of the N-terminal-tagged Rab10 proteins fully rescued the defect in tubular endosome formation in RAB10-KO cells. Although the N-terminal-tagged Rab10 proteins had the ability to localize tubular endosomes in wild-type HeLa cells, they sometimes exhibited a dominant-negative effect on tubular endosome formation. We also found that a conserved lysine residue at amino acid position 3 (K3) in the Rab10 proteins of different species is required for tubular endosome formation. Thus, it will be important to determine whether other Rab isoforms with N-terminal tags behave similarly to their corresponding untagged isoforms by performing appropriate KO–rescue experiments in future studies.
Validity and Reliability of the Tampa Scale for Kinesiophobia for Adolescents with Heart Disease
Authors: White David A. , Black William R. , Cramer Emily , Malloy-Walton Lindsey , Walton Mollie , Martis Laura , Enneking Brandy , Teson Kelli M. , Watson Jessica S. , Gross-Toalson Jami 
Published: January 2025

ABSTRACT
Kinesiophobia (KP) is the fear of movement or physical activity (PA) that is related to a medical condition. In adolescents, KP is associated with depression, anxiety, and impaired quality of life (QoL). Adolescents with heart disease (HD) often avoid PA. Factors that may moderate PA avoidance, such as KP, have not been adequately studied in this population. Purpose: To assess the validity and reliability of a newly adapted Tampa Scale for KP for adolescents with HD (TSK-Heart-A). Methods: The TSK-Heart-A survey consists of 17 Likert scale items, producing a summary score (SS) ranging from 17 (low KP) to 68 (high KP). Following content and face validity, adolescents (age 12-18 years) with arrhythmia disorders or Fontan palliation were recruited. The PROMIS pediatric anxiety and depression short forms, PedsQL generic core and cardiac module, and a PA questionnaire for adolescents (PAQ-A) were used for criterion validity. The TSK-Heart-A was completed twice (20.4 ± 6.3 days apart) for assessment of internal and test-retest reliability. Pearson correlations and Cronbach’s alpha determined validity and reliability, respectively. Results: Adolescents (n = 63) were 15.5 ± 1.8 years-old, 50.8% female, and 69.8% had arrhythmia disorder. Mean TSK-Heart-A SS was 33.8 ± 7.8 (range: 20 to 56). The TSK-Heart-A SS correlated significantly with PROMIS T-scores (anxiety: 49.7 ± 12.2, r = 0.48; depression: 46.9 ± 12.7, r = 0.41), PedsQL score (generic QoL: 75.2 ± 18.9, r = -0.61; cardiac QoL: 74.7 ± 17.5, r = -0.56), and PAQ-A (score: 2.0 ± 0.7, r = -0.35). Test-retest and internal reliability had a total score of r = 0.77 (p = 0.89). Conclusions: The new TSK-Heart-A survey is valid and reliable and suggests KP is present in some adolescents with HD.
How Social Movements Catalyze Firm Innovation
Authors: Odziemkowska Kate , Zhu Yiying 
Published: January 2025

We investigate the impact that social movements have on firm innovation through private politics. We argue that firms strategically respond to private politics by investing in new technologies that address movement-advocated issues material to firms’ performance. Although both contentious private politics—when activists contentiously target firms—and cooperative private politics—when activists and firms collaborate—catalyze innovation, they do so in different ways. Contentious private politics increases the amount of innovation that firms undertake by drawing managerial attention to movement-advocated issues material to the firm, prompting search for solutions to those issues. Conversely, cooperative private politics provides firms access to new knowledge that encourages firms to search for solutions in areas more distant from their existing knowledge and in so doing, increase innovation involving distant recombination on material issues. We find support for our arguments in a matched sample of firms contentiously targeted and with activist collaborations on climate change issues and firms that were not targets of private politics on those issues but had otherwise similar histories of climate-related innovation and relationships with climate movements and other environmental movements. Supplementary analyses corroborate the mechanisms that undergird our theoretical predictions; contentious private politics is associated with more innovation closer to a firm’s expertise, whereas cooperative private politics is associated with innovations that draw on more distant knowledge. We also find that when collaboration follows contention, their respective impacts on innovation are reduced, which may result from firms seeking collaborations for their legitimacy-granting benefits after contention rather than the learning opportunities they offer. Funding: Funding for this research was provided by the Strategic Management Society Strategy Research Foundation [dissertation grant] and Wharton’s Mack Institute for Innovation Management. Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2023.17497 .
The influence of sociodemographic characteristics and hospital type on patient satisfaction: an online survey
Authors: Smadi Audai Naji Al , Abugabah Ahed 
Published: January 2025

Background/Aims Patient satisfaction has received much attention from healthcare organisations as a key quality indicator and as part of a global trend towards patient‑centred care. Despite this, there has been a lack of research on the influence of sociodemographic factors and type of hospital on patient satisfaction, particularly in developing countries. This study aimed to assess the impact of sociodemographic factors and hospital type on patient satisfaction in Jordan. Methods A cross‑sectional study using an online, structured survey was conducted in Jordan between 15 February 2023 and 20 April 2023. All adults living in Jordan who had accessed healthcare services within the previous 2 weeks, either as a patient or caregiver, were eligible to participate. The standard Patient Satisfaction Questionnaires‑18 was used to measure patient satisfaction, with patients rating their satisfaction with items across seven domains. Descriptive statistics, Cronbach's alpha, one‑way analysis of variance and multiple regression analysis were used to analyse the data. Results A total of 653 responses were obtained. The mean overall patient satisfaction score was 2.97 (±0.76), which was classified as neutral (neither satisfied nor dissatisfied). Significant differences were found between participants according to education level, area of residence, monthly salary, health insurance and age group. Significant differences were also found between participants who had attended a public vs private hospital. Multiple regression analysis indicated that area of residence, education level and hospital type were found to significantly influence patient satisfaction. Conclusions To improve patient satisfaction and the quality of healthcare services, organisations must pay more attention to sociodemographic factors such as age, education level, local area, monthly salary, hospital type and health insurance.
Plundering the Skilled Workforce: Depriving Developing Nations of Their Most Valuable Assets
Authors: Gürak Hasan 
Published: January 2025

Abstract
Whether developed or less developed, all countries need skilled mental labor (SML) to use technologies effectively and to attain economic growth and development. Without appropriate SML, no country can make the best use of its firms and institutions. Time and investment are required for an individual to become a skilled mental laborer, but these are not sufficient. The training must be at a level where contemporary technologies can be used effectively, so that the highest benefit can be given to society and companies. The most disturbing aspect of the issue is that although there are very few skilled mental laborers who are educated and equipped with modern qualifications, they generally migrate to more developed and richer countries to achieve better living conditions. Developed countries have found an excuse for this kind of migration by saying “We need skilled mental laborers.” The pertinent critical questions are as follows. While it is acknowledged that developed countries require SML, what about less developed countries? Do they not also have a need for SML? The crucial and vital question is which countries have a greater need for SML, developed countries or less developed countries?
Chinese Modernization and the Prospects of World Modernization: A Review of the 16th Forum of the World Association for Political Economy
Authors: Luo Zhihong , Ding Xiaoqin 
Published: January 2025

Abstract
The 16th forum of the World Association for Political Economy took place in Pingtan, Fujian province, China, on September 25–27, 2023. The theme was “Chinese Modernization and the Prospects of World Modernization.” Experts and scholars from over 20 countries and regions focused on the theme, discussing methods of political economy and theories of modernization research, Chinese modernization and global political and economic structures, the practice of Chinese modernization and the innovation and development of mesoeconomics, research on the political economy of socialism with Chinese characteristics, comparisons of Chinese modernization and capitalist modernization, ecological civilization and the practical path of Chinese modernization, the basic principles of Marxist economics, and the special characteristics of Chinese modernization. The forum has deepened the knowledge and understanding of scholars about Chinese modernization and global modernization, while also contributing wisdom to support people all over the world in pursuing an independent modernization path and promoting the modernization process.
A META analysis and systematic review of the effects of exercise interventions on middle-aged and elderly patients with depression
Authors: Zhang Zheng , Liu Jia-Yun , Zhu Kai-Tuo , Huo Gui-Quan 
Published: January 2025

Objective
This study sought to conduct a meticulous systematic review, delving into the efficacy of exercise interventions on depressive symptoms among middle-aged and older adults. Additionally, we aimed to scrutinize the nuanced influence of various intervention factors on the intricate relationship between exercise and depressive symptoms within this demographic.

Methods
Our investigation involved an extensive search across multiple databases, including PubMed, Embase, Web of Science, and the Cochrane Library, spanning from the inception of these repositories to December 2023. Following a rigorous screening process, we identified and included 12 papers, encompassing a total of 994 subjects.

Results
The meta-analysis unveiled a compelling overall effect size of exercise interventions on depressive symptoms in middle-aged and older individuals, represented by SMD = -0.41, with a 95% confidence interval of [-0.60, -0.22], and P < 0.0001. This statistical evidence underscores the significant and positive impact of exercise interventions on ameliorating depressive symptoms in this demographic. However, a degree of heterogeneity among studies was observed, with I2 = 48% and P = 0.03.

Conclusion
The comprehensive synthesis of outcomes elucidates the pronounced positive effect of exercise interventions in enhancing depressive symptoms among middle-aged and older adults. Specifically, the gentle and balanced exercise series emerges as particularly efficacious in mitigating depression. Furthermore, individual exercises stand out as more effective, with optimal results noted for moderate exercise sessions lasting 30 to 60 minutes. Our findings also highlight the superiority of short-term interventions, followed by medium- and long-term exercise interventions, in terms of efficacy. Nevertheless, recognizing the inherent heterogeneity and potential limitations of our study, we advocate for future large-scale, comprehensive investigations to validate these findings. Additionally, optimizing exercise intervention protocols necessitates a more nuanced understanding, urging further research endeavors to refine strategies aimed at improving depressive symptoms in middle-aged and older adults.
The experience of living with human immunodeficiency virus among adolescents at Felege Hiwot Comprehensive Specialized Hospital Bahir-Dar, Northwest Ethiopia, A phenomenological study
Authors: Guadie Bazezew Asfaw , Belete Minyichil Birhanu , Beyene Meseret Mekuriaw , Melese Ayalew Kassie , Tessema Tarik Yenew , Workineh Yinager 
Published: January 2025

Background
Adolescents who have the human immunodeficiency virus face difficulties in their lives not just from the physical consequences of the illness but also from social stigma and discrimination. The quantitative side of this issue was the focus of earlier Ethiopian research. However, there hasn’t been any prior research done extensively in Ethiopia on the real-life experiences of teenagers infected with HIV. Therefore, in order to address the real issues that these teenagers encounter, it is imperative that we investigate their lived experiences as HIV-positive adolescents.

Objective
The goal is to investigate the experiences that adolescents at Felege Hiwot Comprehensive Specialized Hospital who are infected with HIV have on a daily basis.

Method
A phenomenological approach was conducted among thirteen purposively selected adolescents at Felege Hiwot Comprehensive Specialized Hospital, Bahir-Dar, northwest Ethiopia, from March 25 to April 30, 2023. Information saturation was used to estimate the sample size. Data was gathered through semi-structured open-ended interview guides and in-depth interview techniques. The talk was recorded using an audio recorder. The data was transcribed verbatim. The conceptual translation approach was used to translate the transcribed data from Amharic to English. For additional analysis, the translated data was entered into the Atlas.ti.8 program. To demonstrate findings, the inductive thematic analysis technique was applied using illustrative quotes. Colleague feedback, member checks, and a debriefing were used to guarantee the quality of the data.

Result
Eleven subthemes, including main theme of "lived with burdens of immunodeficiency virus," "disclosure," "ART adherence," and "future aspiration," were used to describe the findings. The participants discussed how difficult it has been for them to deal with social, emotional, and psychological difficulties in addition to living with the HIV infection. They kept their illness a secret from others out of fear of prejudice and stigma. In conclusion, adolescents infected with the human immunodeficiency virus faced a variety of difficulties related to their mental health, relationships, emotions, and compliance. It is advised that the community get ongoing, comprehensive health education in order to prevent stigmatization and discrimination against young people who have the virus.