bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelo de gestión en Clínicas Odontológicas de la Universidad San Gregorio de Portoviejo
Authors: García Briones Martha Yadira , León Zambrano David 
Published: January 2023

La Carrera de Odontología de la Universidad San Gregorio de Portoviejo gestiona clínicas odontológicas para el proceso enseñanza-aprendizaje de sus estudiantes, y para prestar un servicio a la comunidad; por este motivo es necesario contar con un modelo de gestión de recursos que garantice que los procesos fluyan en las diferentes dimensiones: políticas, técnicas y económicas, por tanto, el estudio tiene como objetivo definir y evaluar el modelo de gestión de las clínicas odontológicas de la USGP, realizándose una investigación cualitativa de naturaleza descriptiva y diseño no experimental, tomando información de las clínicas presenciales que se realizaron en la Universidad. Los participantes del estudio fueron 20 personas que laboran en las clínicas, entre profesores, y administradores, quienes contestaron preguntas de acuerdo a un cuestionario estructurado con escala liker, que permitió generar un alfa de cronbach total de 0.92, donde la principal conclusión es que el modelo de gestión maneja los recursos de forma adecuada enfocándose en la calidad del servicio.
Palabras clave: Modelo de gestión, clínicas odontológicas, calidad, servicio
Implementación de un Sistema de Gestión de la Calidad en la empresa Asertia Comercial S.A. en base a la Norma ISO 9001:2015
Authors: Vélez Holguín Joselin Roxana , Anchundia Loor Andrés Miguel 
Published: January 2023

La meta del presente artículo fue establecer los aspectos de la gestión de calidad determinados por la ISO 9001:2015 como estrategia de mejoramiento de los procesos de la empresa Asertia Comercial S.A. siendo esta uno de los principales medios para lograr el crecimiento de las empresas. Para el logro del objetivo del artículo (de tipo exploratorio y descriptivo), se ha hecho una revisión de diversas fuentes documentales científicas, teóricas y estadísticas. Esta información ha sido extraída, analizada y correlacionada en su totalidad, proceso que viabilizó el desarrollo de un diagnostico situacional de la empresa, mediante la que se estableció que no se tienen definidas las políticas y objetivos de calidad, la carencia de misión, visión precisa y documentada, por último, no se cuenta con un sistema de gestión de calidad certificado con normativa internacional. Por medio de este proceso se hace evidente la necesidad aplicar un proceso de mejora en base a un sistema de gestión de calidad.
Diagnóstico entorno al uso de herramientas tecnológicas en estudiantes de educación básica
Authors: Santamaría Espinoza Lisseth Jacqueline , Barzaga Sablón Oscar 
Published: January 2023

El uso de las herramientas tecnológicas en la educación básica es muy común en los actuales momentos, ya que las situaciones acontecidas a nivel mundial han hecho que este tipo de materiales se utilicen de forma permanente enfocándose en el buen uso y su adecuada aplicación en las aulas de clases, por ello el desarrollo del presente trabajo de investigación tiene como objetivo analizar el uso de las herramientas tecnológicas para contribuir al proceso de enseñanza aprendizaje de los estudiantes de educación básica de la Unidad Educativa Sagrada Familia, del cantón Portoviejo. Para lograr este propósito se realizó una investigación con un enfoque de tipo cuali - cuantitativo, fue de tipo exploratorio, empleando los métodos inductivo, deductivo, analítico y sintético, además del empírico ya que se empleó una encuesta a los docentes y una ficha de observación a los estudiantes, para evaluar el grado de utilización de las herramientas tecnológicas. Los resultados evidencian que el diagnóstico entorno al uso de dichas herramientas es deficiente tanto en los docentes como en los estudiantes, debido a que muchos carecen de estas y no existe la práctica constante en las aulas, por ende, los estudiantes no le dan la utilidad adecuada a este tipo de herramientas para desarrollar un aprendizaje significativo. Se concluye, que los docentes tienen dificultades para el uso de este tipo de herramientas tecnológicas y por tanto no motivan al uso de las mismas a sus estudiantes esto debido a que muchos poseen pocos conocimientos sobre dichas herramientas.
EFEKTIVITAS PEMBELAJARAN MATEMATIKA MELALUI WHATSAPP GROUP DITINJAU DARI HASIL BELAJAR MATEMATIKA SISWA KELAS VIII SMP IT MUTIA RAHMA
Authors: Husna Ella Arina , Mardiana Mardiana , Wirevenska Ice 
Published: January 2023

Penelitian ini bertujuan untuk mengetahui efektivitas pembelajaran matematika melalui whatsapp group ditinjau dari hasil belajar siswa kelas VIII SMP IT Mutia Rahma. Jenis penelitian ini adalah penelitian deskriptif kualitatif. Subjek dalam penelitian ini adalah siswa kelas VIII-A SMP IT Mutia Rahma sebanyak 30 siswa dan objek penelitian ini adalah efektivitas pembelajaran melalui Whatsapp Group ditinjau dari hasil belajar Matematika. Instrumen tes yang diberikan dalam penelitian ini yaitu berupa tes soal cerita pada materi sistem persamaan linear dua variabel. Kesesuaian aktivitas guru dan aktivitas siswa dilihat dari kriteria aktivitas guru dan aktivitas siswa minimal baik. Dilihat dari tes hasil belajar ke II bahwa ada 26 siswa yang nilai nya sudah memenuhi KKM 75 yaitu 86%. Oleh karena itu, pembelajaran matematika melalui whatsapp group ditinjau dari hasil belajar matematika siswa kelas VIII SMP IT Mutia Rahma adalah efektif.
Photometry of the Four Anti-Galactocentric Old Open Clusters: Czernik 30, Berkeley 34, Berkeley 75, and Berkeley 76
Authors: Im Hyobin , Kim Sang Chul , Kyeong Jaemann , Park Hong Soo , Lee Joon Hyeop 
Published: January 2023

Abstract
We present a BVI photometric study of four old open clusters (OCs) in the the Milky Way, Czernik 30, Berkeley 34, Berkeley 75, and Berkeley 76 using the observation data obtained with the Small and Moderate Aperture Research Telescope System 1.0 m telescope at the Cerro Tololo Inter-American Observatory, Chile. These four OCs are located at the anti-Galactocentric direction and in the Galactic plane. We determine the fundamental physical parameters for the four OCs, such as age, metallicity, distance modulus, and color excess, using red clump and PARSEC isochrone fitting methods after finding center and size of the four OCs. These four old OCs are 2–3 Gyr old and 6–8 kpc away from the Sun. The metallicity ([Fe/H]) values of the four OCs are between −0.6 and 0.0 dex. We combine data for these four OCs with those for old OCs from five literatures resulting in 236 objects to investigate Galactic radial-metallicity distribution. The gradient of a single linear fit for this Galactocentric [Fe/H] distribution is −0.052 ± 0.004 dex kpc−1. If we assume the existence of a discontinuity in this radial-metallicity distribution, the gradient at Galactocentric radius <12 kpc is −0.070 ± 0.006 dex kpc−1, while that at the outer part is −0.016 ± 0.010 which is flatter than that of the inner part. Although there are not many sample clusters at the outer part, the broken linear fit seems to better follow the observation data.
GOALS-JWST: Mid-infrared Spectroscopy of the Nucleus of NGC 7469
Authors: Armus L. , Lai T. , U V. , Larson K. L. , Diaz-Santos T. , Evans A. S. , Malkan M. A. , Rich J. , Medling A. M. , Law D. R. , Inami H. , Muller-Sanchez F. , Charmandaris V. , Werf P. van der , Stierwalt S. , Linden S. , Privon G. C. , Barcos-Muñoz L. , Hayward C. , Song Y. , Appleton P. , Aalto S. , Bohn T. , Böker T. , Brown M. J. I. , Finnerty L. , Howell J. , Iwasawa K. , Kemper F. , Marshall J. , Mazzarella J. M. , McKinney J. , Murphy E. J. , Sanders D. , Surace J. 
Published: January 2023

Abstract
We present mid-infrared spectroscopic observations of the nucleus of the nearby Seyfert galaxy NGC 7469 taken with the MIRI instrument on the James Webb Space Telescope (JWST) as part of Directors Discretionary Time Early Release Science program 1328. The high-resolution nuclear spectrum contains 19 emission lines covering a wide range of ionization. The high-ionization lines show broad, blueshifted emission reaching velocities up to 1700 km s−1 and FWHM ranging from ∼500 to 1100 km s−1. The width of the broad emission and the broad-to-narrow line flux ratios correlate with ionization potential. The results suggest a decelerating, stratified, AGN-driven outflow emerging from the nucleus. The estimated mass outflow rate is 1–2 orders of magnitude larger than the current black hole accretion rate needed to power the AGN. Eight pure rotational H2 emission lines are detected with intrinsic widths ranging from FWHM ∼125 to 330 km s−1. We estimate a total mass of warm H2 gas of ∼1.2 × 107
M
⊙ in the central 100 pc. The PAH features are extremely weak in the nuclear spectrum, but a 6.2 μm PAH feature with an equivalent width of ∼0.07 μm and a flux of 2.7 × 10−17 W m−2 is detected. The spectrum is steeply rising in the mid-infrared, with a silicate strength of ∼0.02, significantly smaller than seen in most PG QSOs but comparable to other Seyfert 1s. These early MIRI mid-infrared IFU data highlight the power of JWST to probe the multiphase interstellar media surrounding actively accreting supermassive black holes.
Missing for 20 yr: MeerKAT Redetects the Elusive Binary Pulsar M30B
Authors: Balakrishnan Vishnu , Freire Paulo C. C. , Ransom S. M. , Ridolfi Alessandro , Barr E. D. , Chen W. , Krishnan Vivek Venkatraman , Champion D. , Kramer M. , Gautam T. , Padmanabh Prajwal V. , Men Yunpeng , Abbate F. , Stappers B. W. , Stairs I. , Keane E. , Possenti A. 
Published: January 2023

Abstract
PSR J2140−2311B is a 13 ms pulsar discovered in 2001 in a 7.8 hr Green Bank Telescope observation of the core-collapsed globular cluster M30 and predicted to be in a highly eccentric binary orbit. This pulsar has eluded detection since then; therefore, its precise orbital parameters have remained a mystery until now. In this work, we present the confirmation of this pulsar using observations taken with the UHF receivers of the MeerKAT telescope as part of the TRAPUM Large Survey Project. Taking advantage of the beamforming capability of our backends, we have localized it, placing it 1.′2(1) from the cluster center. Our observations have enabled the determination of its orbit: It is highly eccentric (e = 0.879) with an orbital period of 6.2 days. We also measured the rate of periastron advance,

ω

̇

=
0.078
±
0.002

deg

yr

−
1

. Assuming that this effect is fully relativistic, general relativity provides an estimate of the total mass of the system, M
TOT = 2.53 ± 0.08 M
⊙, consistent with the lightest double neutron star systems known. Combining this with the mass function of the system gives the pulsar and companion masses of m

p
< 1.43 M
⊙ and m

c
> 1.10 M
⊙, respectively. The massive, undetected companion could either be a massive white dwarf or a neutron star. M30B likely formed as a result of a secondary exchange encounter. Future timing observations will allow the determination of a phase-coherent timing solution, vastly improving our uncertainty in

ω

̇

and likely enabling the detection of additional relativistic effects, which will determine m

p
and m

c
.
South African nose flies (Diptera, Calliphoridae, Rhiniinae): taxonomy, diversity, distribution and biology
Authors: Thomas-Cabianca Arianna , Villet Martin , Martínez-Sánchez Anabel , Rojo Santos 
Published: January 2023

Rhiniinae (Diptera, Calliphoridae) is a taxon of nearly 400 known species, many of them termitophilous. Approximatelly 160 valid species in 16 genera are Afrotropical, with over 60 of them occurring in South Africa. The taxonomy of this group is outdated, as most studies of the South African taxa were conducted 40 to 70 years ago (mostly by Salvador Peris and Fritz Zumpt). Published information on their biology and ecology is also scarce.An annotated checklist of 73 species of Rhiniinae for South Africa was developed, based on the holdings of sixteen entomological collections in Africa, Europe and North America. Over 3,700 specimens were examined, revealing nine new species records for South Africa (Cosmina undulataMalloch, 1926,Isomyia cuthbertsoni(Curran, 1938),Rhyncomya botswanaZumpt, 1974,R. tristisSéguy, 1933,Stomorhina aptaCurran, 1931,S. malobana(Lehrer, 2007),Thoracites kirkspriggsiKurahashi, 2001,Th. sarcophagoidesKurahashi, 2001 andTrichoberia lanata(Villeneuve, 1920)). We propose one new combinationEurhyncomyia metzi(Zumpt, 1981)comb. nov.(=Rhyncomya metziZumpt, 1981)). Additionally, evidence is presented to removeRhyncomya viduellaVilleneuve, 1927stat. rev.from synonymy withRhyncomya cassotis(Walker, 1849). Relevant novel biological and seasonality information, historical occurrence maps and high-definition photographs for each species are compiled.
Vegetation Classification and Survey in the third year
Authors: Dengler Jürgen , Biurrun Idoia , Jansen Florian , Willner Wolfgang 
Published: January 2023

We report on the completed third volume of Vegetation Classification and Survey (VCS). VCS has been included in the Scopus bibliometric database and will receive its first CiteSore in mid-2023. We announce the 2022 Editors’ Award for a paper selected from the four papers nominated for Editors’ Choice during 2022. We selected Liu et al. (2022; Vegetation Classification and Survey 3: 121–144) for the Editors’ Award. This author team developed a comprehensive hierarchical classification system for the steppe vegetation over China. We present five Special Collections (two concluded and three ongoing) which form a backbone for VCS. Apart from Research Papers, Long and Short Database Reports were the prevailing article category in 2022. By contrast, there were no VCS Methods paper in 2022, and thus we encourage submissions particularly in this category. Finally, we welcome new members to the Editorial Board and open a call for free applications for our Editorial Review Board or as a Linguistic Editor.
Abbreviations: APC = article processing charge; IAVS = International Association for Vegetation Science; VCS = Vegetation Classification and Survey.
Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele
Authors: Grzelak Candice A , Ghajar Cyrus M 
Published: January 2023

Abstract
The human ubiquitin C promoter (UBC)–driven GFP-transgenic mouse (UBC-GFP) transgene integration site was mapped recently to chromosome 17, linked closely to the MHC locus. In this study, we demonstrate a functional consequence of this insertion site in the backcrossed UBC-GFP BALB/c congenic strain [CByJ.B6-Tg(UBC-GFP) 30Scha/J]: rejection of transplanted “syngeneic” 4T1 mammary tumor cells. Rejection of BALB/c-derived 4T1 cells is in all likelihood a consequence of MHC mismatch due to stable inheritance of C57BL/6-derived H-2b (rather than prototypical H-2d) by the BALB/c UBC-GFP strain. These data are a valuable resource to researchers who have previously employed the UBC-GFP congenic strain for attempted syngeneic MHC-matched and allogenic MHC-mismatched studies, as their data likely require reinterpretation. Further, this study reemphasizes the impact of mapping transgene integration sites of commonly used mouse strains as a way of increasing scientific rigor and reproducibility.
Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage
Authors: von Richthofen Helen J , Westerlaken Geertje H A , Gollnast Doron , Besteman Sjanna , Delemarre Eveline M , Rodenburg Karlijn , Moerer Petra , Stapels Daphne A C , Andiappan Anand K , Rötzschke Olaf , Nierkens Stefan , Leavis Helen L , Bont Louis J , Rooijakkers Suzan H M , Meyaard Linde 
Published: January 2023

Abstract
Signal inhibitory receptor on leukocytes-1 (SIRL-1) is an immune inhibitory receptor expressed on human granulocytes and monocytes that dampens antimicrobial functions. We previously showed that sputum neutrophils from infants with severe respiratory syncytial virus (RSV) bronchiolitis have decreased SIRL-1 surface expression compared with blood neutrophils and that SIRL-1 surface expression is rapidly lost from in vitro activated neutrophils. This led us to hypothesize that activated neutrophils lose SIRL-1 by ectodomain shedding. Here, we developed an ELISA and measured the concentration of soluble SIRL-1 (sSIRL-1) in patients with RSV bronchiolitis and hospitalized patients with COVID-19, which are both characterized by neutrophilic inflammation. In line with our hypothesis, sSIRL-1 concentration was increased in sputum compared with plasma of patients with RSV bronchiolitis and in serum of hospitalized patients with COVID-19 compared with control serum. In addition, we show that in vitro activated neutrophils release sSIRL-1 by proteolytic cleavage and that this diminishes the ability to inhibit neutrophilic reactive oxygen species production via SIRL-1. Finally, we found that SIRL-1 shedding is prevented by proteinase 3 inhibition and by extracellular adherence protein from Staphylococcus aureus. Notably, we recently showed that SIRL-1 is activated by PSMα3 from S. aureus, suggesting that S. aureus may counteract SIRL-1 shedding to benefit from preserved inhibitory function of SIRL-1. In conclusion, we report that SIRL-1 is released from activated neutrophils by proteinase 3 cleavage and that endogenous sSIRL-1 protein is present in vivo.
Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity
Authors: Hodgson Rose , Crockford Tanya L , Bhandari Aneesha , Kepple Jessica D , Back Jennifer , Cawthorne Eleanor , Abeler-Dörner Lucie , Laing Adam G , Clare Simon , Speak Anneliese , Adams David J , Dougan Gordon , Hayday Adrian C , Deobagkar-Lele Mukta , Cornall Richard J , Bull Katherine R 
Published: January 2023

Abstract
Prolidase deficiency (PD) is a multisystem disorder caused by mutations in the PEPD gene, which encodes a ubiquitously expressed metallopeptidase essential for the hydrolysis of dipeptides containing C-terminal proline or hydroxyproline. PD typically presents in childhood with developmental delay, skin ulcers, recurrent infections, and, in some patients, autoimmune features that can mimic systemic lupus erythematosus. The basis for the autoimmune association is uncertain, but might be due to self-antigen exposure with tissue damage, or indirectly driven by chronic infection and microbial burden. In this study, we address the question of causation and show that Pepd-null mice have increased antinuclear autoantibodies and raised serum IgA, accompanied by kidney immune complex deposition, consistent with a systemic lupus erythematosus–like disease. These features are associated with an accumulation of CD4 and CD8 effector T cells in the spleen and liver. Pepd deficiency leads to spontaneous T cell activation and proliferation into the effector subset, which is cell intrinsic and independent of Ag receptor specificity or antigenic stimulation. However, an increase in KLRG1+ effector CD8 cells is not observed in mixed chimeras, in which the autoimmune phenotype is also absent. Our findings link autoimmune susceptibility in PD to spontaneous T cell dysfunction, likely to be acting in combination with immune activators that lie outside the hemopoietic system but result from the abnormal metabolism or loss of nonenzymatic prolidase function. This knowledge provides insight into the role of prolidase in the maintenance of self-tolerance and highlights the importance of treatment to control T cell activation.
Cutting Edge: Negative Regulation of Inflammasome Activation by TRAF1 Can Limit Gout
Authors: Mirzaesmaeili Ali , Zangiabadi Safoura , Raspanti Jonathan , Akram Ali , Inman Robert D , Abdul-Sater Ali A 
Published: January 2023

Abstract
Secretion of IL-1β, a potent cytokine that plays a key role in gout pathogenesis, is regulated by inflammasomes. TRAF1 has been linked to heightened risk to inflammatory arthritis. In this article, we show that TRAF1 negatively regulates inflammasome activation to limit caspase-1 and IL-1β secretion in human and mouse macrophages. TRAF1 reduces linear ubiquitination and subsequent oligomerization of the adapter protein, ASC. i.p. injection of monosodium urate crystals resulted in increased inflammatory cell infiltrates and IL-1β production in Traf1 knockout mice compared with wild type littermates. In a model of monosodium urate crystal–induced gout, Traf1 knockout mice exhibited more swelling in the knee joints, increased infiltration of inflammatory cells, and higher expression of proinflammatory cytokines. In summary, this study identifies TRAF1 as a key regulator of IL-1β production and a potential therapeutic target for inflammasome-driven diseases such as gout.
Swiss cheese disease: A rare case of juvenile papillomatosis of the breast mimicking carcinoma in a young female
Authors: Hameed Ronak , Vettuparambil Ajith 
Published: January 2023

ABSTRACT
Juvenile papillomatosis is a rare benign proliferative lesion of breast seen in young females. These patients have been reported to have a strong family history for carcinoma breast. It is rarely diagnosed preoperatively but has distinct histopathological features on postoperative examination. The subsequent treatment and prognosis vary accordingly. Here, we report a case of a 38-year-old female who was operated with a preliminary diagnosis of Mucinous carcinoma of left breast.
Progressive external ophthalmoplegia – A case report
Authors: Kaur Ashmeet , Mathur Kusum , Harsh Anita , Thakar Kapil 
Published: January 2023

ABSTRACT
Progressive external ophthalmoplegia is a slowly progressive hereditary mitochondrial myopathy. Most mitochondrial disorders overlap clinically, enzymatically, and genetically. The most common enzyme defect is the combined deficit of complexes I and IV. Progressive external ophthalmoplegia particularly affects the extraocular muscles and is characterised by ophthalmoplegia, and bilateral ptosis. The ptosis and ophthalmoplegia is unresponsive to anticholinergics, with no effective treatment, but corrective surgery for ptosis as a palliative one. In this article, we report a rare case of a 16-year-old female with characterstic histological features consistent with progressive external ophthalmoplegia.
A Survey of Patient Satisfaction with Telepsychiatry Services Delivered at a Tertiary Care Hospital in Western Punjab during the COVID-19 Pandemic
Authors: Aneja Jitender , Kaur Gurpreet , Udey Bharat 
Published: January 2023

Background:
Previous research has shown promising results of telepsychiatry in the form of patient satisfaction. However, its utilization in the wake of the COVID-19 pandemic and with bare minimum resources in the Indian context is scarcely studied.

Aim:
To evaluate patient satisfaction with telepsychiatry services delivered at a tertiary care hospital in Western Punjab.

Methods:
This study was done among 114 patients who had availed of telepsychiatry services between September and November 2021. The patients were interviewed telephonically using a pretested semi-structured tool that measured patient satisfaction on a 5-point Likert Scale.

Results:
The satisfaction rate was very high for various aspects of telepsychiatry services such as ease of seeking appointments, video quality, attending doctor's concern for the patient, time given, ability to procure medicines using the e-prescription and so on.

Conclusion:
Telepsychiatry services delivered through an easy medium encourage us to further strengthen and undertake more research into this aspect of health-care delivery.