bluuebunny/crossref_metadata_2025_split huggingface dataset:
Necessary condition for the L2 boundedness of the Riesz transform on Heisenberg groups
Authors: DĄBROWSKI DAMIAN , VILLA MICHELE 
Published: May 2023

AbstractLet
$\mu$
be a Radon measure on the nth Heisenberg group
${\mathbb{H}}^n$
. In this note we prove that if the
$(2n+1)$
-dimensional (Heisenberg) Riesz transform on
${\mathbb{H}}^n$
is
$L^2(\mu)$
-bounded, and if
$\mu(F)=0$
for all Borel sets with
${\text{dim}}_H(F)\leq 2$
, then
$\mu$
must have
$(2n+1)$
-polynomial growth. This is the Heisenberg counterpart of a result of Guy David from [Dav91].
Evidence of a Polar Cyclone on Uranus From VLA Observations
Authors: Akins Alex , Hofstadter Mark , Butler Bryan , Friedson A. James , Molter Edward , Parisi Marzia , de Pater Imke 
Published: May 2023

AbstractWe present observations of Uranus in northern spring with the Very Large Array from 0.7 to 5 cm. These observations reveal details in thermal emission from Uranus' north pole at 10s of bars, including a dark collar near 80°N and a bright spot at the polar center. The bright central spot resembles observations of polar emission on Saturn and Neptune at shallower pressures. We constrain the variations in temperature and NH3/H2S abundances which could explain these features. We find that the brightness temperature of the polar spot can be recreated through 5 K temperature gradients and/or 10× depletion of NH3 or H2S vapor between 10 and 20 bars, both consistent with the presence of a cyclonic polar vortex. The contrast of the polar spot may have increased since 2015, which would suggest seasonal evolution of Uranus' polar circulation at depth.
Flexible and frequency reconfigurable CPW-fed monopole antenna with frequency selective surface for IoT applications
Authors: Ibrahim Ahmed A. , Mohamed Hesham. A. , Abdelghany Mahmoud A. , Tammam Emad 
Published: May 2023

AbstractThis paper proposes a flexible, frequency-reconfigurable monopole antenna design with frequency selective surface (FSS) for Internet of Things (IoT) applications. The proposed antenna operates at three of the IoT frequency bands. This antenna is a coplanar waveguide (CPW)-fed monopole with two balanced arms printed on a thin ROGERS 3003 flexible substrate. The length of the right-hand arm of the antenna is used to achieve frequency reconfiguration by using PIN diodes. Three frequency modes of operation have been obtained; the 2.4 GHz frequency band with the right-hand arm is fully truncated, the 3.5 GHz frequency band with the two arms is completely maintained, and the 4 GHz frequency band with the right-hand arm is partially truncated. To improve the gain of the antenna, a simple FSS surface is designed to be placed under the antenna at a distance of 15 mm. The FSS operates efficiently from 2 to 4.5 GHz and has improved the gain of the antenna. A maximum gain of 6.5 dBi, 7.52 dBi, and 7.91 dBi has been achieved at the three frequency bands respectively. The behavior of the flexible antenna has been evaluated in both the flat and bent states, and stable performance has been observed in both cases.
Phase II trial of delta-tocotrienol in neoadjuvant breast cancer with evaluation of treatment response using ctDNA
Authors: Kjær Ina Mathilde , Kahns Søren , Timm Signe , Andersen Rikke Fredslund , Madsen Jonna Skov , Jakobsen Erik Hugger , Tabor Tomasz Piotr , Jakobsen Anders , Bechmann Troels 
Published: May 2023

AbstractNeoadjuvant treatment of breast cancer is applied to an increasing extent, but treatment response varies and side effects pose a challenge. The vitamin E isoform delta-tocotrienol might enhance the efficacy of chemotherapy and reduce the risk of side effects. The aim of this study was to investigate the clinical effect of delta-tocotrienol combined with standard neoadjuvant treatment and the possible association between detectable circulating tumor DNA (ctDNA) during and after neoadjuvant treatment with pathological treatment response. This open-label, randomized phase II trial included 80 women with newly diagnosed, histologically verified breast cancer randomized to standard neoadjuvant treatment alone or in combination with delta-tocotrienol. There was no difference in the response rate or frequency of serious adverse events between the two arms. We developed a multiplex digital droplet polymerase chain reaction (ddPCR) assay for the detection of ctDNA in breast cancer patients that targets a combination of two methylations specific for breast tissue (LMX1B and ZNF296) and one cancer specific methylation (HOXA9). The sensitivity of the assay increased when the cancer specific marker was combined with the ones specific to breast tissue (p < 0.001). The results did not show any association between ctDNA status and pathological treatment response, neither at midterm nor before surgery.
Using machine learning methods to predict electric vehicles penetration in the automotive market
Authors: Afandizadeh Shahriar , Sharifi Diyako , Kalantari Navid , Mirzahossein Hamid 
Published: May 2023

AbstractElectric vehicles (EVs) have been introduced as an alternative to gasoline and diesel cars to reduce greenhouse gas emissions, optimize fossil fuel use, and protect the environment. Predicting EV sales is momentous for stakeholders, including car manufacturers, policymakers, and fuel suppliers. The data used in the modeling process significantly affects the prediction model’s quality. This research’s primary dataset contains monthly sales and registrations of 357 new vehicles in the United States of America from 2014 to 2020. In addition to this data, several web crawlers were used to gather the required information. Vehicles sale were predicted using long short-term memory (LSTM) and Convolutional LSTM (ConvLSTM) models. To enhance LSTM performance, the hybrid model with a new structure called “Hybrid LSTM with two-dimensional Attention and Residual network” has been proposed. Also, all three models are built as Automated Machine Learning models to improve the modeling process. The proposed hybrid model performs better than the other models based on the same evaluation units, including Mean Absolute Percentage Error, Normalized Root Mean Square Error, R-square, slope, and intercept of fitted linear regressions. The proposed hybrid model has been able to predict the share of EVs with an acceptable Mean Absolute Error of 3.5%.
Novel in vivo endometriotic models associated eutopic endometrium by implanting menstrual blood-derived stromal cells from patients with endometriosis
Authors: Zhang Yuejian , He Tiantian , Lin Taoxiu , Guo Qi , Huo Chaoyue , Roberts Song Ze , Yang Mengping , Yang Sichen , Gao Luyi , Zhang Wenjuan , Li Changxiang , Ma Xiaona 
Published: May 2023

AbstractThe eutopic endometrium provides novel insights into endometriotic pathophysiology and treatment. However, no in vivo models currently available are suitable for eutopic endometrium in endometriosis. In this study, we present new endometriotic in vivo models associated with eutopic endometrium using menstrual blood-derived stromal cells (MenSCs). First, we isolated endometriotic MenSCs (E-MenSCs) and healthy MenSCs (H-MenSCs) from the menstrual blood of patients with endometriosis (n = 6) and healthy volunteers (n = 6). Then, we identified MenSCs’ endometrial stromal cell properties using adipogenic and osteogenic differentiation. A cell counting kit-8 and wound healing assay were used to compare the proliferation and migration capability between E-MenSCs and H-MenSCs. Seventy female nude mice were used to prepare endometriotic models related to eutopic endometrium by implanting E-MenSCs relying on three approaches, including surgical implantation using scaffolds seeded with MenSCs, and subcutaneous injection of MenSCs in the abdomen and the back (n = 10). H-MenSCs or scaffolds only were implanted in control groups (n = 10). One month after the surgical implantation and 1 week after the subcutaneous injection, we evaluated modeling by hematoxylin–eosin (H&E) and immunofluorescent staining of human leukocyte antigen α (HLAA). Fibroblast morphology, lipid droplets, and calcium nodules in E-MenSCs and H-MenSCs identified their endometrial stromal cell properties. We noticed that the proliferation and migration of E-MenSCs were considerably enhanced compared to H-MenSCs (P < 0.05). E-MenSCs implanted in nude mice formed ectopic lesions using three approaches (n = 10; lesions formation rate: 90%, 115%, and 80%; average volumes: 123.60, 27.37, and 29.56 mm3), while H-MenSCs in the nude mice shaped nothing at the implantation sites. Endometrial glands, stroma, and HLAA expression in these lesions further verified the success and applicability of the proposed endometriotic modeling. Findings provide in vitro and in vivo models and paired controls associated with eutopic endometrium in women with endometriosis using E-MenSCs and H-MenSCs. The approach of subcutaneous injection of MenSCs in the abdomen is highlighted due to non-invasive, simple, and safe steps, a short modeling period (1 week), and an excellent modeling success rate (115%), which could improve the repeats and success of endometriotic nude mice model and shorten the modeling period. These novel models could nearly intimate human eutopic endometrial mesenchymal stromal cells in the progress of endometriosis, opening a new path for disease pathology and treatment.
Effects of 5G-modulated 3.5 GHz radiofrequency field exposures on HSF1, RAS, ERK, and PML activation in live fibroblasts and keratinocytes cells
Authors: Joushomme Alexandre , Orlacchio Rosa , Patrignoni Lorenza , Canovi Anne , Chappe Yann Loïck , Poulletier De Gannes Florence , Hurtier Annabelle , Garenne André , Lagroye Isabelle , Moisan François , Cario Muriel , Lévêque Philippe , Arnaud-Cormos Delia , Percherancier Yann 
Published: May 2023

AbstractThe potential health risks of exposure to radiofrequency electromagnetic fields from mobile communications technologies have raised societal concerns. Guidelines have been set to protect the population (e.g. non-specific heating above 1 °C under exposure to radiofrequency fields), but questions remain regarding the potential biological effects of non-thermal exposures. With the advent of the fifth generation (5G) of mobile communication, assessing whether exposure to this new signal induces a cellular stress response is one of the mandatory steps on the roadmap for a safe deployment and health risk evaluation. Using the BRET (Bioluminescence Resonance Energy-Transfer) technique, we assessed whether continuous or intermittent (5 min ON/ 10 min OFF) exposure of live human keratinocytes and fibroblasts cells to 5G 3.5 GHz signals at specific absorption rate (SAR) up to 4 W/kg for 24 h impact basal or chemically-induced activity of Heat Shock Factor (HSF), RAt Sarcoma virus (RAS) and Extracellular signal-Regulated Kinases (ERK) kinases, and Promyelocytic Leukemia Protein (PML), that are all molecular pathways involved in environmental cell-stress responses. The main results are (i), a decrease of the HSF1 basal BRET signal when fibroblasts cells were exposed at the lower SARs tested (0.25 and 1 W/kg), but not at the highest one (4 W/kg), and (ii) a slight decrease of As2O3 maximal efficacy to trigger PML SUMOylation when fibroblasts cells, but not keratinocytes, were continuously exposed to the 5G RF-EMF signal. Nevertheless, given the inconsistency of these effects in terms of impacted cell type, effective SAR, exposure mode, and molecular cell stress response, we concluded that our study show no conclusive evidence that molecular effects can arise when skin cells are exposed to the 5G RF-EMF alone or with a chemical stressor.
Reversible metal-insulator transition in SrIrO3 ultrathin layers by field effect control of inversion symmetry breaking
Authors: Gallego Fernando , Tornos Javier , Beltran Juan Ignacio , Peralta Andrea , Garcia-Barriocanal Javier , Yu Guichuan , Rojas Geoffrey , Munuera Carmen , Cabero Mariona , Sanchez-Manzano David , Cuellar Fabian , Sanchez-Santolino Gabriel , Sefrioui Zouhair , Rivera-Calzada Alberto , Mompean Federico Jose , Garcia-Hernandez Mar , Leon Carlos , del Carmen Muñoz Maria , Santamaria Jacobo 
Published: May 2023

AbstractSrIrO3 is a correlated semimetal with narrow t2g d-bands of strong mixed orbital character resulting from the interplay of the spin-orbit interaction due to heavy iridium atoms and the band folding induced by the lattice structure. In ultrathin layers, inversion symmetry breaking, occurring naturally due to the presence of the substrate, opens new orbital hopping channels, which in presence of spin-orbit interaction causes deep modifications in the electronic structure. Here, we show that in SrIrO3 ultrathin films the effect of inversion symmetry breaking on the band structure can be externally manipulated in a field effect experiment. We further prove that the electric field toggles the system reversibly between a metallic and an insulating state with canted antiferromagnetism and an emergent anomalous Hall effect. This is achieved through the spin-orbit driven coupling of the electric field generated in an ionic liquid gate to the electronic structure, where the electric field controls the band structure rather than the usual band filling, thereby enabling electrical control of the effective role of electron correlations. The externally tunable antiferromagnetic insulator, rooted in the strong spin-orbit interaction of iridium, may inspire interesting applications in spintronics.
Residual vulnerabilities to power side channel attacks of lightweight ciphers cryptography competition finalists
Authors: Mozipo Aurelien T. , Acken John M. 
Published: May 2023

AbstractThe protection of communications between Internet of Things (IoT) devices is of great concern because the information exchanged contains vital sensitive data. Malicious agents seek to exploit those data to extract secret information about the owners or the system. Power side channel attacks are of great concern on these devices because their power consumption unintentionally leaks information correlatable to the device's secret data. Several studies have demonstrated the effectiveness of authenticated encryption with advanced data, in protecting communications with these devices. A comprehensive evaluation of the seven (out of 10) algorithm finalists of the National Institute of Standards and Technology (NIST) IoT lightweight cipher competition that do not integrate built‐in countermeasures is proposed. The study shows that, nonetheless, they still present some residual vulnerabilities to power side channel attacks (SCA). For five ciphers, an attack methodology as well as the leakage function needed to perform correlation power analysis (CPA) is proposed. The authors assert that Ascon, Sparkle, and PHOTON‐Beetle security vulnerability can generally be assessed with the security assumptions “Chosen ciphertext attack and leakage in encryption only, with nonce‐misuse resilience adversary (CCAmL1)” and “Chosen ciphertext attack and leakage in encryption only with nonce‐respecting adversary (CCAL1)”, respectively. However, the security vulnerability of GIFT‐COFB, Grain, Romulus, and TinyJambu can be evaluated more straightforwardly with publicly available leakage models and solvers. They can also be assessed simply by increasing the number of traces collected to launch the attack.
Incidence of retained biopsy specimens after esophagogastroduodenoscopy and colonoscopy
Authors: Toy Gregory , Colletier Keegan , Hale Gillian , Valentine John , Gawron Andrew J , Sossenheimer Michael , Peterson Kathryn , Aparicio Rodrigo , Fang John C 
Published: May 2023

Abstract
Background and study aims In gastrointestinal endoscopy, biopsies must transit through the accessory channel and cap, presenting an opportunity for loss of tissue. We sought to determine the incidence of specimen retention in the accessory channel or cap and identify procedure characteristics associated with specimen retention.
Patients and methods After completion of standard endoscopic procedures in which biopsies were obtained, the biopsy cap and accessory channel were inspected, brushed, and irrigated for any retained biopsy specimens according to a standard protocol. For controls, the same protocol was applied to procedures in which biopsies were not obtained. Specimen bottles from the recovery protocol were sent for pathological examination regardless of whether any visible tissue was present.
Results A total of 216 outpatient procedures were included: 55 esophagogastroduodenoscopies (EGDs) and 50 colonoscopies in which biopsies were obtained and 56 EGDs and 55 colonoscopies in the control group. Retained specimens were found in either the cap or channel in 50 of 105 (48%). In 20 of 105 (19%), retained specimens were found just in the cap, in six of 105 (5.7%), retained specimens were found just in the channel, while in 24 of 105 (23%), retained specimens were found in both the cap and channel. Retained specimens were more likely to be found in EGDs compared to colonoscopies (58% vs. 36%, P = 0.031). No retained specimens were found in the control group.
Conclusions Retained specimens are startingly common in standard gastrointestinal endoscopic procedures and could potentially change diagnoses and management. Quality improvement measures should be instituted to monitor prevalence of retained biopsies and methods to prevent them should be developed.
The Fish Bone Technique: An Innovative Approach for the Bony Nasal Pyramid
Authors: Martins Lessandro , Fagundes Marina Serrato Coelho , Koener Heloisa Nardi , Fakih-Gomez Nabil , D'Souza Alwyn R. 
Published: May 2023

AbstractAmong many contributions to the world of art and science, Renaissance artist Leonardo da Vinci created the technique known as sfumato. In this technique, da Vinci considered that the regions to be highlighted should be lit up, while the regions to be hidden should be darkened. Drawing parallel with the face, we can work on the anatomical structures underlying the skin and create a favorable surface anatomy for the entire face, including the nose. However, to achieve the ideal hourglass shape of the nose, the bones must be shaped, and a variety of osteotomies are described and used to achieve this. The new and innovative Fish Bone technique, described in this article, allows for the bony nasal pyramid to be shaped and adapted to the hourglass shape, resulting in a harmonious contour, with smooth transitions and preservation airway.
Risk Factors for Adverse Maternal Outcomes among Patients with Severe Preeclampsia Before 34 Weeks
Authors: Nisly Gabriela , Dillon Jacquelyn L. , Darling Alice , Myers Sabrena , Al Shibli Noor , Gatta Luke A. , West-Honart Annie , Wheeler Sarahn , Grace Matthew R. , Dotters-Katz Sarah K. 
Published: May 2023

Objective This study aimed to characterize rates of maternal morbidity associated with early (<34 wk) preeclampsia with severe features and to determine factors associated with developing these morbidities.
Study Design Retrospective cohort study of patients with early preeclampsia with severe features at a single institution from 2013 to 2019. Inclusion criteria were admission between 23 and 34 weeks and diagnosis of preeclampsia with severe features. Maternal morbidity defined as death, sepsis, intensive care unit (ICU) admission, acute renal insufficiency (acute kidney injury [AKI]), postpartum (PP) dilation and curettage, PP hysterectomy, venous thromboembolism (VTE), PP hemorrhage (PPH), PP wound infection, PP endometritis, pelvic abscess, PP pneumonia, readmission, and/or need for blood transfusion. Death, ICU admission, VTE, AKI, PP hysterectomy, sepsis, and/or transfusion of >2 units were considered severe maternal morbidity (SMM). Simple statistics used to compare characteristics among patients experiencing any morbidity and those not. Poisson regression used to assess relative risks.
Results Of 260 patients included, 77 (29.6%) experienced maternal morbidity and 16 (6.2%) experienced severe morbidity. PPH (n = 46, 17.7%) was the most common morbidity, although 15 (5.8%) patients were readmitted, 16 (6.2%) needed a blood transfusion, and 14 (5.4%) had AKI. Patients who experienced maternal morbidity were more likely to be advanced maternal age, have preexisting diabetes, have multiples, and deliver nonvaginally (all ps < 0.05). Diagnosis of preeclampsia < 28 weeks or longer latency from diagnosis to delivery were not associated with increased maternal morbidity. In regression models, the relative risk of maternal morbidity remained significant for twins (adjusted odds ration [aOR]: 2.57; 95% confidence interval [CI]: 1.67, 3.96) and preexisting diabetes (aOR: 1.64; 95% CI: 1.04, 2.58), whereas attempted vaginal delivery was protective (aOR: 0.53; 95% CI: 0.30, 0.92).
Conclusion In this cohort, more than 1 in 4 patients diagnosed with early preeclampsia with severe features experienced maternal morbidity, whereas 1 in 16 patients experienced SMM. Twins and pregestational diabetes were associated with higher risk of morbidity, whereas attempted vaginal delivery was protective. These data may be helpful in promoting risk reduction and counseling patients diagnosed with early preeclampsia with severe features.
Key Points
The Present Condition of Sickle Cell Disease: An Overview of Stem Cell Transplantation as a Cure
Authors: Hussain Md. Sadique , Chaturvedi Varunesh 
Published: May 2023

AbstractTreatment of sickle cell disease (SCD) remains largely palliative. While it can enhance living standards, persons having SCD still suffer from extreme sickling crises, end-organ destruction, and reduced life expectancy. Increasing research has resulted in the recognition and advancement of stem cell transplantation and gene therapy as possible solutions for SCDs. However, there have been various factors that have hindered their clinical application. The more advantageous of the two, stem cell transplantation, is constrained by a small donor pool, transplant difficulties, and eligibility requirements. The current article reviewed the literature on SCDs, current treatment options, and more particularly the progress of stem cell transplants. It outlined various challenges of stem cell transplant and proposed ways to increase the donor pool using alternative strategies and modifications of regimen conditioning with minimal transplant-related toxicities and associated complications.
Role of Molecular Targeted Therapeutic Drugs in Treatment of Breast Cancer: A Review Article
Authors: Singh Himanshu 
Published: May 2023

AbstractBreast cancer is a multifactor, multistage, and heterogeneous disease. Systemic treatment of breast cancer has changed significantly over the last decade. With a better knowledge of the pathogenesis, researchers and scientists have discovered numerous signaling pathways and synonymous therapeutic targets in breast cancer. Because of the molecular nature of breast cancer, which makes it difficult to understand, previous attempts to treat or prevent it have failed. However, recent decades have provided effective therapeutic targets for treatment. In this review, literature or information on various targeted therapy for breast cancer is discussed. English language articles were explored in numerous directory or databases like PubMed, Web of Sciences, Google Scholar, ScienceDirect, and Scopus. The important keywords used for searching databases are “Breast cancer,” “Targeted therapy in breast cancer,” “Therapeutic drugs in breast cancer,” and “Molecular targets in breast cancer.”