bluuebunny/crossref_metadata_2025_split huggingface dataset:
International differences in gradients in early childhood overweight and obesity: the role of maternal employment and formal childcare attendance
Authors: Panico Lidia , Boinet Cesarine , Akabayashi Hideo , de la Rie Sanneke , Kwon Sarah Jiyoon , Kameyama Yuriko , Keizer Renske , Nozaki Kayo , Perinetti Casoni Valentina , Volodina Anna , Waldfogel Jane , Weinert Sabine , Washbrook Elizabeth 
Published: April 2023

Abstract

Background
There are significant cross-country differences in socio-economic gradients in later childhood and adulthood overweight/obesity; few studies assess whether this cross-national variation is evident from early childhood. Furthermore, the role of childcare in explaining overweight/obesity gradients might vary across countries, given differences in access, quality and heterogeneity within. Additionally, childcare is linked to parental characteristics such as maternal employment. The interplay between childcare and employment in producing early overweight/obesity gradients has received little attention, and might vary cross-nationally.

Methods
Using harmonized data from six high-quality, large datasets, we explore the variation in gradients in early overweight/obesity (at age 3–4 years old) by parental education across several high-income countries (USA, UK, France, the Netherlands, Germany and Japan). We then assess whether differential formal group care use attenuates some of these gradients, and whether this varies across maternal employment.

Results
Gradients in early childhood overweight/obesity by parental education are evident across several developed countries. Countries with higher overall prevalence of early overweight/obesity did not have the largest inequalities across education groups. The contribution of formal group care to producing these gradients varied across countries and across maternal employment status.

Conclusion
Early childhood inequalities in overweight/obesity are pervasive across developed countries, as noted for older children and adults. However, mechanisms producing these gradients vary across national contexts. Our study shows that, given the right context, quality childcare and maternal employment can successfully support healthy weight trajectories and not contribute (or even reduce) social inequalities in early overweight/obesity.
The unknown silent drug reaction in acne patients: rare case of isotretinoin-induced haematuria
Authors: Kapetanovic Igor , Zivanovic Dubravka , Mijuskovic Margita , Minic Snezana 
Published: April 2023

Abstract

Background
Acne vulgaris is one of the most frequent visits to primary care physicians and dermatologists alike. Isotretinoin is the backbone of acne treatment. In most countries, depending on the health care system, isotretinoin is prescribed by dermatologists but primary care physicians are a part of the follow-up and interpreting analysis. Adverse effects of isotretinoin on the kidney and urinary system are mostly limited to sparse case reports. Specifically, gross and microscopic haematuria is not mentioned to be associated with isotretinoin. Lack of data regarding these adverse effects can lead to doubt regarding further patient management not only with dermatologists but also primary care physicians.

Objective
We report a 16-year-old male patient with isotretinoin-induced haematuria with multiple episodes and subsequent challenge and de-challenge. No personal or familial history of nephrological disease was present. Ultrasound imaging and nephrology workup was within normal limits. Other aetiologies were excluded. Nephrology consult stated there was no contraindication for isotretinoin use and was reinstated at 0.6 m/kg/day. More frequent observation was indicated until completion of isotretinoin.

Conclusion
Our case raises awareness to other dermatologists and primary care physicians that haematuria can be secondary to isotretinoin but not a contraindication for further use if asymptomatic and microscopic. More extensive evaluation and monitoring should be done if the patient is symptomatic with other abnormalities and symptoms. Urinalysis should be a part of routine follow-up monitoring in patients on isotretinoin. Furthermore, delineating and differentiating when to refer to a nephrologist is essential for physicians, patients, and the health care system overall.
Specific Distribution of Digital Gait Biomarkers in Parkinson’s Disease Using Body-Worn Sensors and Machine Learning
Authors: Cai Guoen , Shi Weikun , Wang Yingqing , Weng Huidan , Chen Lina , Yu Jiao , Chen Zhonglue , Lin Fabin , Ren Kang , Zeng Yuqi , Liu Jun , Ling Yun , Ye Qinyong 
Published: April 2023

Abstract
Gait impairment leads to reduced social activities and low quality of life in people with Parkinson’s disease (PD). PD is associated with unique gait signs and distributions of gait features. The assessment of gait characteristics is crucial in the diagnosis and treatment of PD. At present, the number and distribution of gait features associated with different PD stages are not clear. Here, we used whole-body multinode wearable devices combined with machine learning to build a classification model of early PD (EPD) and mild PD (MPD). Our model exhibited significantly improved accuracy for the EPD and MPD groups compared with the healthy control (HC) group (EPD vs HC accuracy = 0.88, kappa = 0.75, AUC = 0.88; MPD vs HC accuracy = 0.94, kappa = 0.84, AUC = 0.90). Furthermore, the distribution of gait features was distinguishable among the HC, EPD, and MPD groups (EPD based on variability features [40%]; MPD based on amplitude features [30%]). Here, we showed promising gait models for PD classification and provided reliable gait features for distinguishing different PD stages. Further multicenter clinical studies are needed to generalize the findings.
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
Authors: Freeberg Kaitlin A , Udovich CeAnn C , Martens Christopher R , Seals Douglas R , Craighead Daniel H 
Published: April 2023

Abstract
Advancing age and many disease states are associated with declines in nicotinamide adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ abundance with precursor compounds, such as nicotinamide riboside or nicotinamide mononucleotide, has profound effects on physiological function in models of aging and disease. Translation of these compounds for oral supplementation in humans has been increasingly studied within the last 10 years; however, the clinical evidence that raising NAD+ concentrations can improve physiological function is unclear. The goal of this review was to synthesize the published literature on the effects of chronic oral supplementation with NAD+ precursors on healthy aging and age-related chronic diseases. We identified nicotinamide riboside, nicotinamide riboside co-administered with pterostilbene, and nicotinamide mononucleotide as the most common candidates in investigations of NAD+-boosting compounds for improving physiological function in humans. Studies have been performed in generally healthy midlife and older adults, adults with cardiometabolic disease risk factors such as overweight and obesity, and numerous patient populations. Supplementation with these compounds is safe, tolerable, and can increase the abundance of NAD+ and related metabolites in multiple tissues. Dosing regimens and study durations vary greatly across interventions, and small sample sizes limit data interpretation of physiological outcomes. Limitations are identified and future research directions are suggested to further our understanding of the potential efficacy of NAD+-boosting compounds for improving physiological function and extending human health span.
Support for Older Parents in Need in Europe: The Role of the Social Network and of Individual and Relational Characteristics
Authors: Cohen Liora , Shiovitz-Ezra Sharon , Erlich Bracha 
Published: April 2023

Abstract

Background and Objectives
Adult children form the backbone of informal care for older parents. To date, limited attention has been paid to the complex mechanism of providing support to older parents. The present study investigated mezzo- and micro-level correlates of provision of support to older parents. The focus was on the child–parent relationship in childhood and in the present.

Research Design and Methods
Data were derived from the Survey of Health, Ageing and Retirement in Europe (SHARE). The analytic sample comprised respondents who participated in SHARE Waves 6–8 and reported having an unhealthy mother (N = 1,554) or father (N = 478). We used hierarchical logistic regression to address 3 models including individual resources, child–parent characteristics, and social resources. We conducted separate analyses for mothers and fathers.

Results
Providing support to a parent depended primarily on personal resources followed by the quality of the relationship with the parent. A larger social network of the care provider was also related to increased likelihood of providing support. Support to a mother was associated with positive evaluations of the relationship with her in the present and in childhood. At the same time, negative evaluations of the relationship with the father in childhood were negatively related to providing support to him.

Discussion and Implications
The findings point to a multidimensional mechanism, in which adult children’s resources are a prominent factor in shaping caregiving behaviors toward their parents. Clinical efforts should focus on adult children’s social resources and the quality of the child–parent relationship.
Behavioral Activation: Values-Aligned Activity Engagement as a Transdiagnostic Intervention for Common Geriatric Conditions
Authors: Kennedy Meaghan A , Stevens Courtney J , Pepin Renée , Lyons Kathleen D 
Published: April 2023

Abstract
Scalable, transdiagnostic interventions are needed to meet the needs of a growing population of older adults experiencing multimorbidity and functional decline. Behavioral activation (BA) is a pragmatic, empirically supported treatment for depression that focuses on increasing engagement in values-aligned activities. We propose BA is an ideal transdiagnostic intervention approach for older adults because it (a) specifically targets activity restriction, a shared characteristic of common conditions of aging; and (b) has strong potential for scalability through delivery by a broad range of clinician and nonclinician interventionists and via telehealth. We describe the history of BA and review recent literature demonstrating impacts beyond depression including on cognition, social isolation, and disability. We also describe the feasibility of delivering BA across interventionists, settings, and modalities. Our approach advances scholarship by proposing BA as a scalable, transdiagnostic behavioral intervention to address functional decline in older adults with common geriatric conditions.
Mental health outcomes in health care providers during the COVID-19 pandemic: an umbrella review
Authors: Majid Umair , Hussain Syed Ahmed Shahzaeem , Zahid Anas , Haider Muhammad Hasnain , Arora Ritika 
Published: April 2023

SummaryAs we head into the third year of the COVID-19 pandemic, there is an increasing need to consider the long-term mental health outcomes of health care workers (HCWs) who have experienced overwhelming work pressure, economic and social deprivation, burnout, and post-traumatic stress disorder (PTSD). This scoping umbrella review summarizes the mental health outcomes of published evidence syntheses on HCWs worldwide. We analyzed 39 evidence syntheses representing the findings from 1297 primary studies. We found several persistent fears and concerns (job-related fears, fear of stigmatization, worries about the pandemic, and infection-related fears) that shaped HCW experiences in delivering health care. We also describe several risk factors (job-related, social factors, poor physical and mental health, and inadequate coping strategies) and protective factors (individual and external factors). This is the first scoping umbrella review comprehensively documenting the various risk and protective factors that HCWs have faced during the COVID-19 pandemic. HCWs continue to fear the risk that they may infect their family and friends since they regularly interact with COVID-19 patients. This places HCWs in a precarious situation requiring them to balance risk to their family and friends and potential social deprivation from isolation.
The 2016 UN General Assembly Declaration on the Right to Peace: A Step towards Sustainable Positive Peace within Societies?
Authors: Turan Tuba 
Published: April 2023

Abstract
In 2016, the UN General Assembly adopted the Declaration on the Right to Peace. This article examines whether the implementation of the Declaration can likely lead to the realization of the right to peace in a way that elicits sustainable peace within societies. Thus, diverging from earlier studies, it provides conceptual and practical critiques of the Declaration to evaluate the viability of the right. First, following an in-depth analysis of the Declaration, this article draws on peace and conflict studies to explain what sustainable intra-state peace entails. Second, it establishes that the liberal and positive elements of peace and the frameworks prescribed in the Declaration are inadequate to address horizontal inequalities across all relevant identity groups qua groups, which is required to elicit sustainable peace. Third, it proposes guiding principles to direct implementing institutions, particularly UN bodies and frameworks, towards diagnosing and tackling inequalities across collectivities, thereby complementing the prevailing individualistic human rights approach.
Thrift, Morality, and Migration in the Barbados Savings Bank
Authors: Flores-Villalobos Joan 
Published: April 2023

Abstract
There has been little historiographical attention to working-class banking in the Caribbean. This article adds to the scholarship by considering the founding and use of the Barbados Savings Bank by working-class Black Barbadians. Colonial administrators hoped the bank would teach formerly enslaved Barbadians how to properly transition into the free wage labor force and sought to encourage household arrangements dependent on a male breadwinner who would use the bank for long-term savings. Using the new depositor ledgers of the Barbados Savings Bank, I argue that everyday Barbadians instead used this financial institution as a family repository of targeted savings for the purpose of emigration, defying colonial desires of a dependent workforce organized in patriarchal single-income households.
Association between vasoactive–inotropic score, morbidity and mortality after heart transplantation
Authors: Tohme Joanna , Lescroart Mickael , Guillemin Jérémie , Orer Pascal , Dureau Pauline , Varnous Shaida , Leprince Pascal , Coutance Guillaume , Bouglé Adrien 
Published: April 2023

Abstract

OBJECTIVES
The aim of this study was to evaluate the association between vasoactive–inotropic score (VIS), calculated in the 24 h after heart transplantation, and post-transplant mortality and morbidity.

METHODS
This was an observational single-centre retrospective study. Patients admitted to surgical intensive care unit after transplantation, between January 2015 and December 2018, were reviewed consecutively. VISmax was calculated as dopamine+ dobutamine+ 100 × epinephrine + 100 × norepinephrine + 50 × levosimendan + 10 × milrinone (all in µg/kg/min) + 10 000 × vasopressin (units/kg/min), using the maximum dosing rates of vasoactive and inotropic medications in the 24 h after intensive care unit admission. The primary outcome was mortality at 1 year post-transplant. The secondary outcomes included length of stay, duration of mechanical ventilation and inotropic support and the occurrence of septic shock, ventilator-associated pneumonia, bloodstream infection or renal replacement therapy.

RESULTS
A total of 151 patients underwent heart transplantation and admitted to intensive care unit. The median VISmax was 39.2 (interquartile range = 19.4–83.0). VISmax was independently associated with 1-year post-transplant mortality, as well as recipient age [hazard ratio (HR) = 1.004, P-value = 0.013], recipient gender (female to male: hazard ratio = 2.23, P-value = 0.047) and combined transplantation (hazard ratio = 2.85, P-value = 0.048). There was a significant association between VISmax and duration of mechanical ventilation (P-value &lt; 0.001), length of stay (P-value = 0.002), duration of infused inotropes (P-value &lt; 0.001), occurrence of bloodstream infections, septic shocks, ventilation-acquired pneumonia and renal replacement therapy.

CONCLUSIONS
VISmax calculated during the first 24 h after postoperative intensive care unit admission in transplanted patients is independently associated with 1-year mortality. In addition, length of stay, duration of mechanical ventilation and infused inotropes increased with increasing VISmax.
Sex and Estrous Cycle Are Not Mediators of S-Ketamine’s Rapid-Antidepressant Behavioral Effects in a Genetic Rat Model of Depression
Authors: Arjmand Shokouh , Vadstrup Pedersen Marie , Silva Nicole R , Landau Anne M , Joca Sâmia , Wegener Gregers 
Published: April 2023

Abstract

Background
Recent preclinical and clinical studies have shed light on the possible impact of sex and estrous/menstrual cycle on ketamine’s antidepressant action but with incongruous results. The preclinical studies that have shown the effects of ovarian sex hormones have not done so in animal models of depression. Thus, the aim of the present study is to scrutinize the acute behavioral responses to a subanesthetic dose of S-ketamine in males vs females and in different estrous phases in free-cycling females in a well-powered translational approach.

Methods
We evaluated the behavioral sensitivity to 20 mg/kg S-ketamine (i.p.) in male and female Flinders Sensitive Line rats (FSLs) and their counterpart Flinders Resistant Line rats (FRLs) subjected to the open field and forced swim tests. Female rats were disaggregated into different estrous phases, and the behavioral outcomes were compared.

Results
Acute administration of S-ketamine had robust antidepressant-like effects in FSLs. Within our study power, we could not detect sex– or estrous cycle–specific different antidepressant-like responses to S-ketamine in FSLs. Fluctuations in the levels of ovarian sex hormones across different estrous cycles did not behaviorally affect S-ketamine’s rapid-acting antidepressant mode of action. No sex-related or estrous cycle–related impact on behavioral despair was observed even among FRLs and saline-treated FSLs.

Conclusions
We conclude that physiological oscillations of estrogen and progesterone levels neither amplify nor diminish the behavioral antidepressant-like effect of S-ketamine. In addition, fluctuations of ovarian sex hormones do not predispose female animals to exhibit enhanced or reduced depressive-like and anxiety-like behaviors.
The Growth–Employment–Poverty Nexus in Africa
Authors: Fields Gary S 
Published: April 2023

AbstractThis paper focuses on employment and the labour market as a key mechanism leading from growth to poverty reduction in Africa. Given that the development goals are economy-wide outcomes—less poverty, shared prosperity, more and better job opportunities, etc.—the required analysis must be at the market level. Individual-level analysis is not enough. The paper brings together insights from labour economics and from development economics. It draws upon Fields’ work over decades at the intersection of these two fields. A concluding section presents suggestions for policy analysis.
The provenance of the forms of knowledge thesis
Authors: Standish Paul 
Published: April 2023

Abstract
This paper sets out to consider what is probably the most widely known of the writings of Paul Hirst, ‘Liberal Education and the Nature of Knowledge’. It examines the central concept of the ‘forms’ and goes on to explore the provenance of the ideas he develops in this paper, exposing diversity and some tension between these. At the end it offers some brief suggestions regarding the prospects for the idea of a liberal education today in the light of Hirst’s views.
Human metabolism and body composition: prospects for novel studies
Authors: Pontes-Silva André , Lopes André Luiz , Maciel Erika da Silva , Quaresma Fernando Rodrigues Peixoto , Dibai-Filho Almir Vieira 
Published: April 2023

Abstract

Context
Most articles on gut microbiota argue the importance of body composition assessment in patients; however, body composition assessments are fragile (ie, with methodological limitations) in the most recent studies.

Objective
To present two suggestions for further research using the human body composition assessment.

Methods
The methods used in this study are based on a Pinto et al article published in Nutrition Reviews.

Data extraction
On the basis of data

obtained from the PubMed, SCOPUS, LILACS, and Web of Science databases, Pinto et al provided a current survey of intermittent fasting protocols and an understanding of the outcomes to date in terms of the profile of the intestinal microbiota in obese organisms.

Data analysis
Of the 82 original articles identified from the databases, 35 were eliminated because of duplication and 32 were excluded for not meeting the inclusion criteria. Two additional articles found in a new search were added, yielding a total of 17 studies to be included in this review. Among the protocols, alternate-day fasting and time-restricted feeding were the most common, and they were shown to have different mechanisms of metabolic signaling. Time-restricted feeding influences body mass control and biochemical parameters by regulating the circadian system and improving satiety control systems by acting on leptin secretion. In contrast, alternate-day fasting leads to a reduction of ±75% of all energy consumption regardless of dietary composition, in addition to promoting hormonal adjustments that promote body mass control. Furthermore, both protocols could remodel the intestinal microbiota by changing the Firmicutes to Bacteroidetes ratio and increasing the abundance of strains such as Lactobacillus spp. and Akkermansia that have a protective effect on metabolism against the effects of body mass gain.

Conclusion
Changes in adipose tissue (eg, body mass loss, control, gain) should be interpreted via the sum of skinfolds in absolute values, waist perimeter, and patients' body proportionality, because fat is just a fraction of the adipocyte (lipid).
Language, Sexuality, History
Authors: Leap William L. 
Published: April 2023

Abstract
Discussions of language and sexuality within history typically aim to produce a chronology tracing how language use related to sexuality at some previous time became language use related to sexuality in more recent settings. But there are “far more possibilities for living than time as measurement would lead us to believe” (Dinshaw 2012: 137), and historical inquiry needs to capture those possibilities. This chapter proposes that a queer historical linguistics offers a useful framework for exploring those possibilities. Applying “scavenger methodology” to examples from an ongoing project (Leap 2020), the chapter explores relationships between language and sexuality in the years preceding the so-called Stonewall rebellion (late June 1969).