bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synovial fluid S100A8, S100A9, and HNP 1-3 in the diagnosis of periprosthetic joint infection: a prospective, double-blind trial
Authors: Xu Ying , Ma Xueting , Guo Haoran , Tang Hairong , Liu Jiayu , Wang Chi , Wang Chengbin 
Published: March 2023

Abstract
Background
Periprosthetic joint infection (PJI) is a common and serious complication after total joint arthroplasty. Early and accurate diagnosis of PJI can improve its therapeutic effect. However, there is no single method that can independently diagnose all PJI. Finding appropriate biomarkers is essential for the diagnosis of PJI. In this study, we prospectively investigated the clinical diagnostic value of synovial fluid S100 calcium-binding protein A8 (S100A8) and S100 calcium-binding protein A9 (S100A9) in PJI, and investigated the types of α-defensins that have diagnostic value for PJI.
Methods
Synovial fluid samples were collected from 82 patients with suspected PJI after hip and knee arthroplasty. Patients were divided into PJI group (n = 39) and non-PJI group (n = 43) according to the Musculoskeletal Infection Society (MSIS) guideline. The matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was used to determine S100A8, S100A9, α-defensins and internal reference standards (IRS) in synovial fluid. The “peak of target protein/peak of IRS” was recorded for further analysis. The receiver operating characteristic curve (ROC) was used to analyze the diagnostic efficiency of S100A8, S100A9, α-defensins for PJI.
Results
We detected elevated S100A8, three S100A9 variants, as well as three types of α-defensins in the synovial fluid of PJI patients by MALDI-TOF-MS. The sensitivity, specificity and the area under ROC curve (AUC) for synovial fluid S100A8 were 97.4%, 86.0% and 0.964 (95% CI: 0.929–0.998), and were 87.2%, 88.4% and 0.902 (95% CI: 0.823–0.980), respectively, for S100A9. Synovial fluid α-defensins 1–3, also known as human neutrophil peptides 1–3 (HNP 1–3), with the sensitivity, specificity and AUC of 89.7%, 83.7% and 0.933 (95% CI: 0.884–0.982), respectively. When synovial fluid S100A8, S100A9 and HNP 1–3 are combined with synovial fluid white blood cell count (SF-WBC) and polymorphonuclear neutrophil percentage (SF-PMN), the diagnostic efficiency could be improved.
Conclusion
Synovial fluid S100A8, S100A9 and HNP 1–3 have satisfactory diagnostic efficiency for the diagnosis of PJI.
Impacts of obesity and metabolic health on global subclinical left cardiac function: TyG index may be a predictor of subclinical left cardiac dysfunction
Authors: Mei Jiajie , Li Yanhua , Dong Jianli , Bai MiaoMiao , Jiang Yinong , Qu Xiaofeng , Yin Lili 
Published: March 2023

Abstract
Background: Obesity is a recognized risk factor for heart failure. People with similar weights may have different metabolic health. Notably, insulin resistance is a hallmark of obesity and a feature of heart failure. We aimed to evaluate the effects of obesity and metabolic health status on subclinical left cardiac function. We also investigated whether insulin resistance (TyG index) plays a role in BMI-linked subclinical left cardiac dysfunction.
Methods: The study involved 403 volunteers. Multivariate logistic regression models were used to assess associations between obesity, metabolic health, and overall subclinical left cardiac function .Mediating analysis was used to explore the role of the TyG index in the association between BMI and left cardiac function. Finally, ROC analysis was performed to explore the predictive value of the TyG index in subclinical left cardiac dysfunction.
Results: The correlation analysis showed that metabolic unhealth increased the risk of subclinical left ventricular (LV) dysfunction; obesity was associated with an increased risk of global left cardiac dysfunction regardless of metabolic health status. The TyG index mediated 25% of the associations between BMI and Left atrial (LA) function. ROC analysis exhibited that the TyG index can be used as a predictor of LA dysfunction (AUC = 0.63), and the optimal cut-off point for the TyG index is 9.33.
Conclusions: Even a "non-obese metabolically unhealthy" is a detrimental state of early LV function; obesity remains a major risk factor for global subclinical left cardiac dysfunction. Using the TyG index could allow early identification of individuals at high risk of subclinical left cardiac dysfunction.
Registration number：ChiCTR2200057991；Date of registration: 2022-03-25
URL:http://www.chictr.org.cn/showproj.aspx?proj=162316
Structure and titanium distribution of feiite characterized using synchrotron single-crystal X-ray diffraction techniques
Authors: Zurkowski Claire , Lavina Barbara , Prissel Kelsey , Chariton Stella , Prakapenka Vitali B. , Fei Yingwei 
Published: March 2023

Abstract
A solid solution of the mineral feiite (Fe3TiO5) was recently discovered in a shock-induced melt pocket of the Shergotty martian shergottite. It is particularly interesting for its potential as an indicator of pressure-temperature (P-T) and oxygen fugacity in martian crustal and mantle material. To date, complete crystallographic analysis of feiite has not been conducted, as the mineral was previously analyzed by electron backscatter diffraction on micrometer-size grains (Ma et al. 2021). Here we report a convergent crystal-structure model for feiite based on synchrotron single-crystal X-ray diffraction data collected on three grains of feiite synthesized at 12 GPa and 1200 °C. Feiite adopts the CaFe3O5 structure type (Cmcm, Z = 4), which is composed of two octahedral M1 and M2 sites and one trigonal prismatic M3 site (M = metal) in a ratio of 1:2:1. The three feiite grains with composition Ti0.46–0.60Fe3.54–3.40O5 were best modeled by substituting Ti4+ into only the octahedral M2 site, accounting for 30% of this site. Comparisons of the measured average bond lengths in the coordination polyhedra with the optimized Ti4+–O, Fe2+–O, and Fe3+–O bond lengths suggest that ferrous iron occupies the trigonal M3 site, while iron is mixed valence in the octahedral M1 and M2 sites. The Ti4+ and Fe3+ content constrained by our crystal-chemical analyses suggests that at least ~30% of the available iron must be ferric (i.e., Fe3+/Fetotal = 0.3) for the sample synthesized at 12 GPa and 1200 °C and higher P-T conditions may be needed to form the end-member feiite (Fe32+TiO5).
The 450 nm (2.8 eV) cathodoluminescence emission in quartz and its relation to structural defects and Ti contents
Authors: Götze Jens , MacRae Colin M. , Pan Yuanming , Wilson Nicholas C. , Torpy Aaron , Audédat Andreas 
Published: March 2023

Abstract
The origin of the common blue 450 nm (2.8 eV) cathodoluminescence (CL) emission in natural and synthetic quartz has been investigated using a combination of CL microscopy and spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, and trace-element analysis by electron micro-probe analysis as well as inductively coupled plasma-mass spectrometry (ICP-MS). The study shows that the appearance of the ~450 nm emission band can be attributed to two different defects in quartz. First, a transient luminescence can be explained by structural defects in oxygen deficient quartz. The luminescence model implies self-trapped exciton (STE) emission related to oxygen vacancies. This type of CL emission is frequent in high-purity synthetic quartz and natural quartz of hydrothermal origin. Second, in Ti-rich quartz from natural samples (e.g., quartz phenocrysts in rhyolites) and synthetic quartz of Ti-diffusion experiments, an additional 450 nm (2.8 eV) emission was detected, which is stable under the electron beam. The intensity of this ~450 nm emission band correlates with the concentration of trace Ti in quartz, and substitutional Ti4+ at the Si4+ position was proved by EPR spectroscopy. In quartz crystals with elevated Ti concentrations both intrinsic and extrinsic blue CL emissions at ~450 nm can coexist, hindering a thorough characterization and quantification of the CL signal. A reliable distinction of the two different CL emission bands is possible by fitting the peaks of the CL spectra, and the peak width of the 450 nm emission can be used to differentiate the STE from the Ti4+ emission. However, the definitive technique is through the observation of CL peak shape change over time at a point by collecting a time series of CL spectra in conjunction with EPR spectroscopy and trace-element analysis of the Ti concentration.
WOMEN IN THE WORK PLACE – AN EMPIRICAL ANALYSIS OF THE CHALLENGE OF WORK LOAD
Authors: Wani Ambreen , Ahmad Mufeed 
Published: March 2023

Female employment has witnessed a drastic paradigm shift. Several factors like improving literacy, change is the socio-economic scenario, zest for financial independence and ambition; are responsible for this changing trend. Being the largest employer of women in India, education sector is witnessing drastic changes. The present study examines Work-Life Balance of women working in various universities of J&K with emphasis on work pressure the females face in the course of trying to balance their professional life with their personal life.
Investigation shows that most working women are upset with the amount of work-load in the universities. Women who work for longer hours tend to be more dissatisfied with their Work-Life Balance. The study strongly suggests that academic expectations must be attuned with the demands of a woman’s personal life or else a woman can never give her best.
Coliphages as indicators of primary wastewater treatment efficiency by constructed wetlands
Authors: Hernandez-Rivera Gisela , Santiago-Rodriguez Tasha M. , Toranzos Gary A. 
Published: March 2023

Abstract
Constructed wetlands are an efficient and cost-effective system for the treatment of wastewater that can be reused for diverse purposes, including irrigation; however, few studies have determined the efficiency of microbial removal by constructed wetlands in tropical regions. Therefore, the present study aimed to determine the microbial quality of the influent and effluent of a constructed wetland in Puerto Rico, using traditional bacterial indicators (i.e., thermotolerant coliforms and enterococci), as well as somatic and male-specific (F+) coliphages. Results showed that over 99.9 and 97.7% of thermotolerant coliforms and enterococci were removed after treatment by constructed wetlands, respectively. Notably, approximately 84.0% of male-specific (F+) coliphages were removed, while somatic and total coliphages exhibited differing removal percentages at different steps during treatment by constructed wetlands. The potential risk of the presence of enteric viruses in treated wastewater by constructed wetlands may increase when considering traditional bacterial indicators exclusively. The present study may aid in the efforts to determine public health concerns associated with the exposure of bioaerosols resulting from wastewater treatment by constructed wetlands.
Prediction of groundwater quality index in the Gaza coastal aquifer using supervised machine learning techniques
Authors: Aish Adnan M. , Zaqoot Hossam Adel , Sethar Waqar Ahmed , Aish Diana A. 
Published: March 2023

Abstract
This paper investigates the performance of five supervised machine learning algorithms, including support vector machine (SVM), logistic regression (LogR), decision tree (DT), multiple perceptron neural network (MLP-NN), and K-nearest neighbours (KNN) for predicting the water quality index (WQI) and water quality class (WQC) in the coastal aquifer of the Gaza Strip. A total of 2,448 samples of groundwater were collected from the coastal aquifer of the Gaza Strip, and various physical and chemical parameters were measured to calculate the WQI based on weight. The prediction accuracy was evaluated using five error measures. The results showed that MLP-NN outperformed other models in terms of accuracy with an R value of 0.9945–0.9948, compared with 0.9897–0.9880 for SVM, 0.9784–0.9800 for LogR, 0.9464–0.9247 for KNN, and 0.9301–0.9064 for DT. SVM classification showed that 78.32% of the study area fell under poor to unsuitable water categories, while the north part of the region had good to excellent water quality. Total dissolved solids (TDS) was the most important parameter in WQI predictions while and were the least important. MLP-NN and SVM were the most accurate models for the WQI prediction and classification in the Gaza coastal aquifer.
Structural Insight on GPR119 Agonist as Potential Therapy for Type II
Diabetes: A Comprehensive Review
Authors: Nema Priyanshu , Asati Vivek , Kendya Priyadarshi , Gupta Twinkle , Agarwal Shivangi , Kori Shivam , Kashaw Varsha , Iyer Arun K. , Kashaw Sushil Kumar 
Published: March 2023

Abstract:
Diabetes Mellitus (DM) is a long-term metabolic condition that is characterized by excessive
blood glucose. DM is the third most death-causing disease, leading to retinopathy, nephropathy,
loss of vision, stroke, and cardiac arrest. Around 90% of the total cases of diabetic patients have Type
II Diabetes Mellitus (T2DM). Among various approaches for the treatment of T2DM. G proteincoupled
receptors (GPCRs) 119 have been identified as a new pharmacological target. GPR119 is distributed
preferentially in the pancreas β-cells and gastrointestinal tract (enteroendocrine cells) in humans.
GPR119 receptor activation elevates the release of incretin hormones such as Glucagon-Like
Peptide (GLP1) and Glucose Dependent Insulinotropic Polypeptide (GIP) from intestinal K and L
cells. GPR119 receptor agonists stimulate intracellular cAMP production via Gαs coupling to adenylate
cyclase. GPR119 has been linked to the control of insulin release by pancreatic β-cells, as well as
the generation of GLP-1 by enteroendocrine cells in the gut, as per in vitro assays. The dual role of the
GPR119 receptor agonist in the treatment of T2DM leads to the development of a novel prospective
anti-diabetic drug and is thought to have decreased the probability of inducing hypoglycemia.
GPR119 receptor agonists exert their effects in one of two ways: either by promoting glucose absorption
by β-cells, or by inhibiting α-cells' ability to produce glucose. In this review, we summarized potential
targets for the treatment of T2DM with special reference to GPR119 along with its pharmacological
effects, several endogenous as well as exogenous agonists, and its pyrimidine nucleus containing
synthetic ligands.
Glutathione S Transferase Theta1 and Mu1 (GSTT1 and GSTM1)
Deletion Among Autistic Population of India
Authors: Hegde Rajat , Hegde Smita , Kulkarni Suyamindra S. , Das Kusal K. , Gai Pramod B. 
Published: March 2023

Introduction:
Oxidative stress is an imbalance between an organism's reactive oxygen
species (ROS) production and antioxidant defence capacity. Long-term oxidative stress
contributes to cellular ageing and plays a role in the pathogenesis of several diseases. Several
investigations indicated that oxidative stress has a role in the pathogenesis of ASD.

Objectives:
Present study was undertaken to record the association of GSTTT1 and GSTM1 null
genotype among the autistic population of India.

Methods:
Genomic DNA was isolated from 108 autistic children along with healthy agematched
control. The quality and quantity of the isolated genomic DNA were analysed. GSTT1
and GSTM1 null genotype was analysed using polymerase chain reaction with internal positive
control. Statistical analysis was performed using SPSS 15.0.

Results:
Present study included 85 males and 23 females with a mean age of 11.7 ± 3.5 and 75
males and 33 females with a mean age of 11 ± 2.0 in the control group. 32 (29.6%) autistic
cases showed null genotypes for GSTT1 and 21(19.4%) autistic children showed null genotypes
for GSTM1. 3 (2.85%) control children showed a null genotype for GSTT1 and 5 (4.6%) control
children showed a null genotype for GSTM1. The GSTT1 and GSTM1 null genotypes were
observed to be significantly associated with the risk of autism (p value-0.0001, OR-14.73, 95%
CI 4.35-49.90) and (p value-0.003, OR-4.731, 95% CI 1.71-13.08) respectively.

Conclusion:
The findings of our study suggested that GSTT1 and GSTM1 null genotype is one
of the potential risk factors for autism through oxidative stress mechanism in our population.
The application of the make-a-match cooperative learning model to improve civics learning outcomes
Authors: Nurjanah Nurjanah , Samsuri Samsuri , Ramadan Syahri 
Published: March 2023

The study aims to reveal the learning outcome in the civic education of Junior High School 2 Wates students by implementing the cooperative learning model “Make A Match” type with film media on competency standard understanding of various constitutions used in Indonesia. This research is classroom action research conducted in three cycles. The technique used for data collection was observation and achievement test. The data analysis technique used the procedure of data reduction, data presentation, and conclusion drawing. The results show increased student learning outcomes in the cognitive, affective, and psychomotor domains from the first to the second and third cycles. It can be concluded from this study that implementing the cooperative learning model of “Make A Match” type with film media can improve the learning outcomes in the civic education of the students of class VIII C Junior High School 2 Wates in the academic year of 2015/2016. Therefore it can be used as an alternative learning model in civic education.
Impact of Overnight Glucose on Next-Day Functioning in Adults With Type 1 Diabetes: An Exploratory Intensive Longitudinal Study
Authors: Pyatak Elizabeth A. , Spruijt-Metz Donna , Schneider Stefan , Hernandez Raymond , Pham Loree T. , Hoogendoorn Claire J. , Peters Anne L. , Crandall Jill , Jin Haomiao , Lee Pey-Jiuan , Gonzalez Jeffrey S. 
Published: March 2023

OBJECTIVE
While there is evidence that functioning, or ability to perform daily life activities, can be adversely influenced by type 1 diabetes, the impact of acute fluctuations in glucose levels on functioning is poorly understood.

RESEARCH DESIGN AND METHODS
Using dynamic structural equation modeling, we examined whether overnight glucose (coefficient of variation[CV], percent time &lt;70 mg/dL, percent time &gt;250 mg/dL) predicted seven next-day functioning outcomes (mobile cognitive tasks, accelerometry-derived physical activity, self-reported activity participation) in adults with type 1 diabetes. We examined mediation, moderation, and whether short-term relationships were predictive of global patient-reported outcomes.

RESULTS
Overall next-day functioning was significantly predicted from overnight CV (P = 0.017) and percent time &gt;250 mg/dL (P = 0.037). Pairwise tests indicate that higher CV is associated with poorer sustained attention (P = 0.028) and lower engagement in demanding activities (P = 0.028), time &lt;70 mg/dL is associated with poorer sustained attention (P = 0.007), and time &gt;250 mg/dL is associated with more sedentary time (P = 0.024). The impact of CV on sustained attention is partially mediated by sleep fragmentation. Individual differences in the effect of overnight time &lt;70 mg/dL on sustained attention predict global illness intrusiveness (P = 0.016) and diabetes-related quality of life (P = 0.036).

CONCLUSIONS
Overnight glucose predicts problems with objective and self-reported next-day functioning and can adversely impact global patient-reported outcomes. These findings across diverse outcomes highlight the wide-ranging effects of glucose fluctuations on functioning in adults with type 1 diabetes.
Peningkatan Hasil Belajar Peserta Didik dalam Pembelajaran Tematik Terpadu dengan Model PBL di kelas V SD
Authors: Yanti Rena Maiburni , Mansurdin Mansurdin 
Published: March 2023

AbtractThis research was backgrounded by unintegrated learning process applied to students in which a teacher, in this model of integrated thematic learning, had not introduced the students to actual cases happened in their environments. This research was aimed to describe the application of Problem Based Learning model to improve learning outcomes in integrated thematic learning to the students of grade V on SDN 114/III Dusun Baru Siulak Sungai Penuh Kerinci. The type of this research is CAR (Classroom Action Research) with mixed qualitative and quantitative approach. It was found in RPP that cycle I was 79.16% (C) in average, increased to 96.4% (SB) at cycle II. The implementation of learning on teacher aspect cycle I was 82.14% (B) in average and increased to 94.4% (SB) on cycle II. Meanwhile, the student aspect on cycle I was 82.14% (B) and increased to 94.4% (SB) on cycle II. The learning outcomes received on cycle I was 66.6% (D) in average and increased to 92.59% (SB) in average on cycle II
Peningkatan Hasil Belajar Peserta didik Pada Pembelajaran Tematik Terpadu Menggunakan Model Think Pair ShareLearning Kelas IV SD
Authors: Hafizah Nicken , Zuardi Zuardi 
Published: March 2023

AbstractThis study aims to describe the improvement of student learning outcomes in Integrated thematic Learning using Discovery Learning model in class IV SDN 05 Koto Tangah Kabupaten Agam. This research used a qualitative and quantitative approach. This type of research i.e. Research Action class (PTK). The subject of research is the grade IV SDN 05 Koto Tangah Kabupaten Agam Feed as many as 20 students. Research conducted two cycles. The design of the research include, (1) planning, (2) implementation, (3) and (4) observation of the reflection. The results showed an increase in: a) the RPP cycle I 86,37 % (B Cycle II 95,45% (SB) implementation on aspect of teacher cycle I82,82% (B) , a cycle II 93,75% (SB) c) Implementation on aspect students cycle I % 82,82 % (B and Cycle II II 93,75% (SB) student learning outcomes Cycle I 75 (B) cycle II 83 (B). Thus the model of Discovery Learning can improve the learning results of integrated thematic grade IV SDN 05 Koto Tangah Kabupaten Agam.
Peningkatan Proses Pembelajaran Tematik	Terpadu Menggunakan Model Discovery Learning pada Siswa Kelas V SD
Authors: Putri Elisa Deka , Ahmad Syafri 
Published: March 2023

This research is motivated by integrated thematic learning that has not been well implemented, is still in the process of improving. This causes the integrated thematic learning process to be carried out to the maximum. The purpose of this study, to improve the integrated thematic learning process using the Discovery Learning model. This type of research is classroom action research using qualitative and quantitative approaches. This research was conducted in the second semester of the 2018/2019 academic year. The results of the study showed an increase in: (1) the learning plan, namely cycle I obtained a percentage of 83.33% (Good), cycle II obtained a percentage of 97.2% (Very Good). (2) the implementation of learning cycle I obtained a percentage of 79,7% , cycle II obtained a percentage of 96,9% (Very Good). It can be concluded that the Discovery Learning model can improve the integrated thematic learning process in elementary schools.
UTILIZATION OF SATELLITE IMEGERY FOR MAPPING SETTLEMENT DEVELOPMENT TRENDS IN THE CITY BUKITTINGGI
Authors: Anwar Sherena Aurelia , Ernawati Ernawati 
Published: March 2023

This research was conducted to see the trend of the development of residential areas in the City of Bukittinggi using remote sensing methods. This technique is considered important and effective in providing spatial information on the earth's surface quickly, precisely and easily. This study aims to classify land use for residential areas using Landsat 8 OLI (Operational Land Imaginer) imagery. In this study, the maximum likelihood classification (MLC) method was used. The research used is descriptive with a quantitative approach, namely using numerical data, analysis, interpretation and presenting data in numerical form for sampling in identifying the results of land use for settlements in the City of Bukittinggi.
The research results have changed in the last 5 years, it was found that there was an increase in residential areas of 7.92 ha in 2016 and 2021 using Landsat imagery. The results of the research in the form of a map are land use maps in the City of Bukittinggi to see the distribution of residential areas.