bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Propelled Ultrasmall AuNPs‐Tannic Acid Hybrid Nanozyme with ROS‐Scavenging and Anti‐Inflammatory Activity for Drug‐Induced Liver Injury Alleviation
Authors: Zhou Chunyu , Zhang Liang , Xu Zhongsheng , Sun Tao , Gong Mingfu , Liu Yun , Zhang Dong 
Published: February 2023

AbstractDeveloping nanomedicines with superior reactive oxygen species (ROS) scavenging capability has emerged as a promising strategy in treating ROS‐related diseases, for example, drug‐induced liver injury. However, designing nanoscavengers with the self‐propelling ability to scavenge ROS actively remains challenging. Here, a self‐propelled silica‐supported ultrasmall gold nanoparticles‐tannic acid hybrid nanozyme (SAuPTB) is designed that can effectively alleviate acetaminophen (APAP)‐induced liver injury by scavenging excessive ROS and regulating inflammation. SAuPTB exhibits multienzyme activity and displays significantly enhanced diffusion under hydrogen peroxide (H2O2). This in vitro research shows that SAuPTB can effectively eliminate ROS, increasing the viability of H2O2‐stimulated cells and reducing the cytotoxicity of APAP/H2O2‐treated AML12 cells. The in vivo studies show that SAuPTB can accumulate at inflammatory sites in mouse liver, resulting in the decrease of alanine aminotransferase, aspartate aminotransferase, and ROS, reduction in pro‐inflammatory cytokines and chemokines, hence reduced hepatocyte necrosis, liver injury, and mortality. Furthermore, SAuPTB activates the nuclear erythroid 2‐related factor 2 pathway to upregulate antioxidative genes and reduce oxidative stress. Finally, the liver shows decreased high mobility group box 1 and F4/80+macrophages, suggesting an anti‐inflammatory response. This work provides a novel design strategy of nanozymes for ROS‐related disease treatment.
Oral Metal‐Free Melanin Nanozymes for Natural and Durable Targeted Treatment of Inflammatory Bowel Disease (IBD)
Authors: Huang Qiong , Yang Yuqi , Zhu Yan , Chen Qiaohui , Zhao Tianjiao , Xiao Zuoxiu , Wang Mingyuan , Song Xiangping , Jiang Yitian , Yang Yunrong , Zhang Jinping , Xiao Yang , Nan Yayun , Wu Wei , Ai Kelong 
Published: February 2023

AbstractOral antioxidant nanozymes bring great promise for inflammatory bowel disease (IBD) treatment. To efficiently eliminate reactive oxygen species (ROS), various metal‐based nanozymes have been developed for the treatment of IBD but their practical applications are seriously impaired by unstable ROS‐eliminating properties and potential metal ion leakage in the digestive tract. Here, the authors for the first time propose metal‐free melanin nanozymes (MeNPs) with excellent gastrointestinal stability and biocompatibility as a favorable therapy strategy for IBD. Moreover, MeNPs have extremely excellent natural and long‐lasting characteristics of targeting IBD lesions. In view of the dominant role of ROS in IBD, the authors further reveal that oral administration of MeNPs can greatly alleviate the six major pathological features of IBD: oxidative stress, endoplasmic reticulum stress, apoptosis, inflammation, gut barrier disruption, and gut dysbiosis. Overall, this strategy highlights the great clinical application prospects of metal‐free MeNPs via harnessing ROS scavenging at IBD lesions, offering a paradigm for antioxidant nanozyme in IBD or other inflammatory diseases.
Synthesis of Phase Junction Cadmium Sulfide Photocatalyst under Sulfur‐Rich Solution System for Efficient Photocatalytic Hydrogen Evolution
Authors: Zheng Xinlong , Song Yiming , Liu Yuhao , Li Jing , Yang Yingjie , Wu Daoxiong , Liu Weifeng , Shen Yijun , Tian Xinlong 
Published: February 2023

AbstractPhotocatalyst with excellent semiconductor properties is the key point to realize the efficient photocatalytic hydrogen evolution (PHE). As a representative binary metal sulfide (BMS) semiconductor, cadmium sulfide (CdS) possesses suitable bandgap of 2.4 eV and negative conduction band potential, which has a great potential to realize efficient visible‐light PHE performance. In this work, CdS with unique cubic/hexagonal phase junction is facilely synthesized through a sulfur‐rich butyldithiocarbamate acid (BDCA) solution process. The results illustrate that the phase junction can efficiently enhance the separation and transfer of photogenerated electron–hole pairs, resulting in an excellent PHE performance. In addition, the sulfur‐rich property of BDCA solution leads to the absence of additional sulfur sources during the synthesis of CdS photocatalyst, which greatly simplifies the fabrication process. The optimal PHE rate of the BDCA‐synthesized phase junction CdS photocatalyst is 7.294 mmol g–1 h–1 and exhibits a favorable photostability. Moreover, density function theory calculations indicated that the apparent redistribution of charge density in the cubic/hexagonal phase junction regions gives a suitable hydrogen adsorption capacity, which is responsible for the enhanced PHE activity.
A Rare‐Earth Selenite with Unexpectedly Well‐Balanced Ultraviolet Nonlinear Optical Functionality, Sc(HSeO3)3
Authors: Bai Zhiyong , Lee Jihyun , Kim Heewon , Kuk Yunseung , Choi Myung‐Ho , Hu Chun‐Li , Ok Kang Min 
Published: February 2023

AbstractEstablishing high performance ultraviolet (UV) nonlinear optical (NLO) selenite crystals with well‐balanced properties is very challenging attributable to their strong absorption for UV light. Here a rare‐earth selenite, Sc(HSeO3)3, with excellent UV NLO properties is introduced. Sc(HSeO3)3 crystallizing in the polar NCS space group, Cc, features a 3D archetiture built up by interconnected ScO6 octahedra and HSeO3 groups. The crystal exhibits remarkably well‐balanced UV‐NLO functionality, namely, the shortest absorption edge (214 nm) among NLO‐active selenites, wide bandgap (5.28 eV), large phase‐matchable SHG response (5 × KDP), and sufficiently large birefringence (cal. 0.105 @1064 nm). Detailed DFT calculations have been performed to elucidate the structure–property relationships. This work provides a new example of discovering novel UV NLO selenite materials.
3D Printed Graphene‐Based Metamaterials: Guesting Multi‐Functionality in One Gain
Authors: Du Junjie , Fu Gangwen , Xu Xi , Elshahawy Abdelnaby M. , Guan Cao 
Published: February 2023

AbstractAdvanced functional materials with fascinating properties and extended structural design have greatly broadened their applications. Metamaterials, exhibiting unprecedented physical properties (mechanical, electromagnetic, acoustic, etc.), are considered frontiers of physics, material science, and engineering. With the emerging 3D printing technology, the manufacturing of metamaterials becomes much more convenient. Graphene, due to its superior properties such as large surface area, superior electrical/thermal conductivity, and outstanding mechanical properties, shows promising applications to add multi‐functionality into existing metamaterials for various applications. In this review, the aim is to outline the latest developments and applications of 3D printed graphene‐based metamaterials. The structure design of different types of metamaterials and the fabrication strategies for 3D printed graphene‐based materials are first reviewed. Then the representative explorations of 3D printed graphene‐based metamaterials and multi‐functionality that can be introduced with such a combination are further discussed. Subsequently, challenges and opportunities are provided, seeking to point out future directions of 3D printed graphene‐based metamaterials.
Stabbündelstützen mit hochfestem Bewehrungsstahl
Authors: Röß Rudolf , Ameri Shaghayegh , Mensinger Martin , Zehfuß Jochen 
Published: February 2023

AbstractIm Rahmen des AiF‐Projekts „Stabbündelstützen mit hochfestem Bewehrungsstahl“ wurde das Tragverhalten von Stabbündelstützen bei Raumtemperatur und im Brandfall untersucht. Stabbündelstützen sind eine neue Art von Verbundstützen. Hierzu wird ein Bündel aus hochfesten Bewehrungsstäben mit einer Streckgrenze von 670 MPa in ein Stahlrohr eingestellt und anschließend mit Mörtel verpresst. Das Bündel kann aus 1, 3, 7 oder 19 Stäben bestehen. Um das Tragverhalten zu analysieren, wurden relevante Materialparameter im Kalt‐ und im Brandfall bestimmt. Anschließend wurden großmaßstäbliche Knickversuche unter Raumtemperatur und im Brandfall durchgeführt. Unter Berücksichtigung der erzielten Ergebnisse wurde ein FE‐Modell erstellt und kalibriert. Auf dieser Basis wurde ein Bemessungskonzept ausgearbeitet.
Locating illness behavior as a social practice among women in Jammu city
Authors: Sharma Swati , Mishra Anindya J. 
Published: February 2023

AbstractThis paper seeks to understand the patterns of social experiences of women patients by means of an empirical study undertaken in the Jammu region of the union territory of Jammu and Kashmir in India. Social factors play an immense role in determining the onset and management of lifestyle diseases among South Asian women. These social factors entail some peculiar entities that require detailed investigation. Data were collected in Government Medical College Hospital, Jammu, and its allied hospitals. Results show that for women, social factors and their impact on illness patterns have a strong bearing on their care‐seeking behavior. Care‐seeking behavior of women in this part of the country is determined by their social status and is determined by the meanings that are provided to these illness experiences. Therefore, physical pain and related symptoms were not found to impact these women as much as changes in their socio‐familial status due to the onset of lifestyle diseases. These diseases can broadly be categorized into three categories, namely, socially stigmatising diseases, socially irrelevant diseases, and socio‐economically burdensome diseases. However, these categories are not fixed for a particular disease. As the experiences of the women undergo change, so does the categorization of the disease. Hence, diabetes may be a socially irrelevant disease at one point of time. Nevertheless, as the condition of the patient deteriorates, diabetes becomes a socio‐economically burdensome disease. That is why lifestyle diseases keeps circulating from one category to another every time a patient encounters a new result arising from a lifestyle disease.
Drell-Yan production in third-generation gauge vector leptoquark models at NLO+PS in QCD
Authors: Haisch Ulrich , Schnell Luc , Schulte Stefan 
Published: February 2023

Abstract
Motivated by the long-standing hints of lepton-flavour non-universality in the b → cℓν and b → sℓ+ℓ− channels, we study Drell-Yan ditau production at the Large Hadron Collider (LHC). In the context of models with third-generation gauge vector leptoquarks (LQs), we calculate the complete $$ \mathcal{O} $$
O
(αs) corrections to the pp → τ+τ− process, achieving next-to-leading order (NLO) plus parton shower (NLO+PS) accuracy using the POWHEG method. We provide a dedicated Monte Carlo code that evaluates the NLO QCD corrections on-the-fly in the event generation and use it to study the numerical impact of NLO+PS corrections on the kinematic distributions that enter the existing experimental searches for non-resonant ditau final states. Based on our phenomenological analysis we derive NLO accurate constraints on the masses and couplings of third-generation gauge vector LQs using the latest LHC ditau search results corresponding to an integrated luminosity of around 140 fb−1 of proton-proton collisions at $$ \sqrt{s} $$

s

= 13 TeV. The presented NLO+PS generator allows for an improved signal modelling, making it an essential tool for future ATLAS and CMS searches for vector LQs in τ+τ− final states at LHC Run III and beyond.
On two-body and three-body spin correlations in leptonic $$ t\overline{t}Z $$ production and anomalous couplings at the LHC
Authors: Rahaman Rafiqul 
Published: February 2023

Abstract
We study the anomalous $$ t\overline{t}Z $$
t

t
¯

Z
couplings in the $$ t\overline{t}Z $$
t

t
¯

Z
production in leptonic final state at the 13 TeV LHC. We use the polarizations of top quarks and Z boson, two-body and three-body spin correlations among the top quarks and Z boson, and the cross section to probe the anomalous couplings. We estimate one parameter and simultaneous limits on the couplings of the effective vertex as well as the effective operators for a set of luminosities 150 fb−1, 300 fb−1, 1000 fb−1, and 3000 fb−1. The polarizations and the spin correlations are found to be helpful on top of the cross section to better constrain the anomalous couplings.
Loop corrections in Minkowski spacetime away from equilibrium. Part II. Finite-time results
Authors: Chaykov Spasen , Agarwal Nishant , Bahrami Sina , Holman R. 
Published: February 2023

Abstract
Loop corrections to finite-time correlation functions in quantum field theories away from equilibrium can be calculated using the in-in path integral approach. In this paper, we calculate the unequal-time two-point correlator for different massless self-interacting scalar quantum field theories on a Minkowski background, starting the field evolution at an arbitrary initial time. We find the counterterms that need to be added to UV-renormalize the result, including usual in-out counterterms in the dynamics and additional initial state counterterms that are required to cancel all UV divergences. We find that the late-time limit of the renormalized correlation function exhibits a linear or logarithmic growth in time, depending on whether the interaction strength is dimension-one or dimensionless, respectively. The late-time correlations match those obtained in our companion paper and, as shown there, the divergences do not indicate a real IR issue, consistent with what one would expect in Minkowski.
Phase and stability of black strings in Einstein-Gauss-Bonnet theory at large D
Authors: Suzuki Ryotaku , Tomizawa Shinya 
Published: February 2023

Abstract
The phase and stability of black strings in the Einstein-Gauss-Bonnet (EGB) theory are investigated by using the large D effective theory approach. The spacetime metric and thermodynamics are derived up to the next-to-leading order (NLO) in the 1/D expansion. We find that the entropy current defined by the Iyer-Wald formula follows the second law. As in the Einstein theory, the entropy difference from the total mass produces an entropy functional for the effective theory. Including the NLO correction, we find that for the large Gauss-Bonnet coupling constant αGB, the Gregory-Laflamme instability of uniform black strings needs longer wavelength. Moreover, we show that the critical dimension, beyond which non-uiform black strings becomes more stable than uniform ones, increases as αGB becomes large, and approaches to a finite value for αGB→ ∞.
Ultraviolet completion of pseudo-Nambu-Goldstone dark matter with a hidden U(1) gauge symmetry
Authors: Liu Dan-Yang , Cai Chengfeng , Jiang Xue-Min , Yu Zhao-Huan , Zhang Hong-Hao 
Published: February 2023

Abstract
We propose an ultraviolet completion model for pseudo-Nambu-Goldstone dark matter with a hidden U(1) gauge symmetry. Compared to previous studies, this setup is simpler, introducing less interactions. Dark matter scattering off nucleons is highly suppressed by the ultraviolet scale and direct detection constraints can be easily evaded. The kinetic mixing between the hidden U(1) and the U(1)Y gauge fields would lead to dark matter decays. We find that the current bound on the dark matter lifetime implies that the ultraviolet scale should be higher than 1010 GeV. The phenomenological constraints from the 125 GeV Higgs measurements, the dark matter relic density, and indirect detection of dark matter annihilation are also investigated.
Stable cohomology of graph complexes
Authors: Felder Matteo , Naef Florian , Willwacher Thomas 
Published: February 2023

AbstractWe study three graph complexes related to the higher genus Grothendieck–Teichmüller Lie algebra and diffeomorphism groups of manifolds. We show how the cohomology of these graph complexes is related, and we compute the cohomology as the genusgtends to$$\infty $$∞. As a byproduct, we find that the Malcev completion of the genusgmapping class group relative to the symplectic group is Koszul in the stable limit, partially answering a question of Hain.
Chemotherapie ± Androgenrezeptorantagonisten beim metastasierten hormonsensitiven Prostatakarzinom
Authors: Wenzel Mike , Hoeh Benedikt , Chun Felix K. H. , Mandel Philipp 
Published: February 2023

Zusammenfassung
Hintergrund
Nachdem die alleinige Androgendeprivationstherapie (ADT) lange Zeit die Goldstandardbehandlung des metastasierten hormonsensitiven Prostatakarzinoms (mHSPC) war, wurde diese in den letzten Jahren durch Doublet-Kombinationstherapien aus ADT + erweiterte Hormontherapie (ARTA, „androgen receptor targeted agent“) oder ADT + Docetaxel-Chemotherapie abgelöst. Erstmals stehen nun Daten aus Triplet-Kombinationstherapien aus ADT + ARTA (Abirateron/Darolutamid) + Docetaxel-Chemotherapie zur Verfügung.

Fragestellung
Welcher mHSPC-Patient profitiert von einer „Doublet“- vs. „Triplet-Kombinationstherapie“ und welches Nebenwirkungsspektrum ist jeweils zu erwarten?

Ergebnisse
Die aktuellen Triplet-Therapien (ADT + Docetaxel + Abirateron/Darolutamid) zeigen eine Verlängerung des Gesamtüberlebens gegenüber der Doublet-Therapie aus ADT + Docetaxel aller mHSPC (ARASENS) bzw. primär metastasierten „High-volume-“ (PEACE-1) mHSPC-Patienten. Im Setting des High-volume-mHSPC zeigt sich dieser positive Gesamtüberlebenseffekt explizit für die Triplet-Kombination aus ADT + Docetaxel + Abirateron. Beim Low-volume-mHSPC zeigt sich dieser Effekt lediglich für das progressionsfreie Überleben – jedoch nicht für das Gesamtüberleben. Ähnliche Darolutamid‑/Triplet-Kombinationstherapie’ Daten (High- vs. Low-volume-mHSPC) liegen aktuell nicht vor. Die Nebenwirkungsraten von „Triplet- vs. Doublet-Kombinationstherapie“ sind nur leicht erhöht und v. a. auf typische Chemotherapie-assoziierte (Neutropenie) und Androgenrezeptorantagonisten (ARTA)-spezifische Nebenwirkungen (Abirateron) zurückzuführen.

Zusammenfassung
Die ADT-Mono- und die „Doublet-Kombinationstherapie“ aus ADT + Docetaxel sollten in der Erstlinientherapie beim mHSPC keine Rolle mehr spielen. Bis zum Vorliegen weiterführender Daten über den Zusatznutzen der „Triplet-Kombinationstherapie“ in relevanten Subgruppen, stellen die Kombinationstherapien aus ADT + ARTA bzw. ADT + ARTA + Docetaxel in Abhängigkeit patientenspezifischer Charakteristika (Alter, ECOG [Eastern Cooperative Oncology Group], Metastasenlast, primäre/sekundäre Metastasierung) die aktuelle primären Therapieoptionen dar.
3XOR Games with Perfect Commuting Operator Strategies Have Perfect Tensor Product Strategies and are Decidable in Polynomial Time
Authors: Bene Watts Adam , Helton J. William 
Published: February 2023

AbstractWe consider 3XOR games with perfect commuting operator strategies. Given any 3XOR game, we show existence of a perfect commuting operator strategy for the game can be decided in polynomial time. Previously this problem was not known to be decidable. Our proof leads to a construction, showing a 3XOR game has a perfect commuting operator strategy iff it has a perfect tensor product strategy using a 3 qubit (8 dimensional) GHZ state. This shows that for perfect 3XOR games the advantage of a quantum strategy over a classical strategy (defined by the quantum-classical bias ratio) is bounded. This is in contrast to the general 3XOR case where the optimal quantum strategies can require high dimensional states and there is no bound on the quantum advantage. To prove these results, we first show equivalence between deciding the value of an XOR game and solving an instance of the subgroup membership problem on a class of right angled Coxeter groups. We then show, in a proof that consumes most of this paper, that the instances of this problem corresponding to 3XOR games can be solved in polynomial time.
Diverse Microbial Hot Spring Mat Communities at Black Canyon of the Colorado River
Authors: Moreno Ivan J. , Brahamsha Bianca , Donia Mohamed S. , Palenik Brian 
Published: February 2023

AbstractThe thermophilic microbial mat communities at hot springs in the Black Canyon of the Colorado River, thought to harbor the protistan human pathogen Naegleria fowleri, were surveyed using both culture-independent and -dependent methods to further understand the ecology of these hot spring microbiomes. Originating from Lake Mead source water, seven spring sites were sampled, varying in temperature from 25 to 55 °C. Amplicon-based high-throughput sequencing of twelve samples using 16S rRNA primers (hypervariable V4 region) revealed that most mats are dominated by cyanobacterial taxa, some but not all similar to those dominating the mats at other studied hot spring systems. 18S rRNA amplicon sequencing (V9 region) demonstrated a diverse community of protists and other eukaryotes including a highly abundant amoebal sequence related to Echinamoeba thermarum. Additional taxonomic and diversity metric analyses using near full-length 16S and 18S rRNA gene sequencing allowed a higher sequence-based resolution of the community. The mat sequence data suggest a major diversification of the cyanobacterial orders Leptolyngbyales, as well as microdiversity among several cyanobacterial taxa. Cyanobacterial isolates included some representatives of ecologically abundant taxa. A Spearman correlation analysis of short-read amplicon sequencing data supported the co-occurrences of populations of cyanobacteria, chloroflexi, and bacteroidetes providing evidence of common microbial co-occurrences across the Black Canyon hot springs.
Class II two-peptide lanthipeptide proteases: exploring LicTP for biotechnological applications
Authors: Barbosa Joana C. , Mösker Eva , Faria Raquel , Süssmuth Roderich D. , Mendo Sónia , Caetano Tânia 
Published: February 2023

Abstract

The enzymatic machinery involved in the biosynthesis of lantibiotic is an untapped source of proteases with different specificities. Lanthipeptide biosynthesis requires proteolysis of specific target sequences by known proteases, which are encoded by contiguous genes. Herein, the activity of lichenicidin A2 (LicA2) trimming proteases (LicP and LicT) was investigated in vivo. Firstly, the impact of some residues and the size of the peptide were evaluated. Then followed trials in which LicA2 leader was evaluated as a tag to direct production and secretion of other relevant peptides. Our results show that a negatively charged residue (preferably Glu) at cleavage site is important for LicP efficacy. Some mutations of the lichenicidin hexapeptide such as Val-4Ala, Asp-5Ala, Asn-6Ser, and the alteration of GG-motif to GA resulted in higher processing rates, indicating the possibility of improved lichenicidin production in Escherichia coli. More importantly, insulin A, amylin (non-lanthipeptides), and epidermin were produced and secreted to E. coli supernatant, when fused to the LicA2 leader peptide. This work aids in clarifying the activity of lantibiotic-related transporters and proteases and to evaluate their possible application in industrial processes of relevant compounds, taking advantage of the potential of microorganisms as biofactories.

Key points
• LicM2 correct activity implies a negatively charged residue at position -1.
• Hexapeptide mutations can increase the amount of fully processed Bliβ.
• LicA2 leader peptide directs LicTP cleavage and secretion of other peptides.

Graphical abstract