bluuebunny/crossref_metadata_2025_split huggingface dataset:
ICU health care workers opinion on physician-assisted-suicide and euthanasia: a French survey
Authors: Acquier Mathieu , Boyer Alexandre , Guidet Bertrand , Lautrette Alexandre , Reignier Jean , Thiery Guillaume , Robert René 
Published: March 2023

Abstract
Background
In France, physician-assisted suicide or euthanasia are not legal but are still debated. French intensive care unit (ICU) health care workers (HCWs) have an insider’s perspective on the global quality of the patient’s end-of-life, whether it occurs in ICU or not. However, their opinion about euthanasia/physician-assisted suicide remains unknown. The aim of this study is to investigate the opinion of French ICU HCWs about physician-assisted suicide/euthanasia.

Results
A total of 1149 ICU HCWs participated to a self-administered anonymous questionnaire: 411 (35.8%) physicians and 738 (64.2%) non-physicians. Among them, 76.5% indicated they were in favor of legalizing euthanasia/physician-assisted suicide. Non-physicians HCWs were significantly more in favor of the legalization of euthanasia/physician assisted suicide than physicians (87% vs 57.8% p < 0.001). Euthanasia/physician-assisted suicide of an ICU patient raised the most important difference in positive judgment between physicians and non-physicians HCWs (80.3% vs 42.2%; p < 0.001 of non-physicians and physicians, respectively). The questionnaire included three case vignettes of concrete examples which participated to the increase in the rate of response in favor of euthanasia/physician-assisted suicide legalization (76.5–82.9%; p < 0.001).

Conclusions
Keeping in mind the unknown representation of our sample, ICU HCWs, particularly non physicians, would be in favor of a law legalizing euthanasia/physician-assisted suicide.
A structural equation modelling of the direct and indirect factors associated with functional status over time as measured by WHODAS-32 items among postpartum women in Northwest Ethiopia
Authors: Malaju Marelign Tilahun 
Published: March 2023

Abstract
Introduction
Full functional status recovery which is a multidimensional concept, that includes personal care, infant and family care, social and occupational activities and adjusting to the role of motherhood may require several months to achieve. However, most study designs on postpartum maternal functional status were cross-sectional, providing limited insights into functional status patterns over time and the mediating relationships among variables associated with it during the postpartum period.

Objective
To investigate the patterns of functional status over time and the mediating relationships among variables associated with functional status after childbirth.

Methods
From October 2020 to March 2021, 775 women in Northwest Ethiopia participated in a community-based follow-up study that was linked to a health institution. Functional status was measured by the Amharic version of WHODAS 2.0 instrument. Structural equation modelling was used to determine the direct and indirect effects of predictor variables on individual domains of functional status as measured by WHODAS 2.0 instrument.

Results
Higher fear of childbirth score, anxiety and PTSD score had a direct deleterious effect (increased risk of functional disability) on the overall functional status and six domains of WHODAS 2.0 (cognition, mobility, self-care, getting along with people, household life activities and community participation) at the first, second and third follow up periods. Higher social support had a direct protective effect (decreased risk of functional disability) on all domains of WHODAS 2.0 and the overall functional status at the three follow up periods. Higher social support had also an indirect protective effect through fear of birth on the six domains of WHODAS 2.0 and the overall functional status throughout the follow up period. Higher PTSD symptom score had also an indirect deleterious effect (increased risk of functional disability) through fear of birth on the overall functional status and six domains of WHODAS 2.0 (higher disability) throughout the follow up period. Complications of delivery management had a direct deleterious effect (increased disability score) on the domains of getting along with people, household life activities, mobility, self-care and community participation and on the overall functional status disability score.

Conclusion
Maternal functioning in the postpartum period is initially impaired, but improves over time. Despite improvement, maternal morbidities are correlated with worse functioning scores compared to women without these morbidities. Interventions should target on the mediating role of fear of child birth, life threatening event of health risk and PTSD with the deleterious effects of complications of delivery management, poor social support, vaginal mode of delivery, anxiety, poor physical and mental quality of life on functional status of postpartum women.
The localization of molecularly distinct microglia populations to Alzheimer's disease pathologies using QUIVER
Authors: Shahidehpour Ryan K. , Nelson Abraham S. , Sanders Lydia G. , Embry Chloe R. , Nelson Peter T. , Bachstetter Adam D. 
Published: March 2023

AbstractNew histological techniques are needed to examine protein distribution in human tissues, which can reveal cell shape and disease pathology connections. Spatial proteomics has changed the study of tumor microenvironments by identifying spatial relationships of immunomodulatory cells and proteins and contributing to the discovery of new cancer immunotherapy biomarkers. However, the fast-expanding toolkit of spatial proteomic approaches has yet to be systematically applied to investigate pathological alterations in the aging human brain in health and disease states. Moreover, post-mortem human brain tissue presents distinct technical problems due to fixation procedures and autofluorescence, which limit fluorescence methodologies. This study sought to develop a multiplex immunohistochemistry approach (visualizing the immunostain with brightfield microscopy). Quantitative multiplex Immunohistochemistry with Visual colorimetric staining to Enhance Regional protein localization (QUIVER) was developed to address these technical challenges. Using QUIVER, a ten-channel pseudo-fluorescent image was generated using chromogen removal and digital microscopy to identify unique molecular microglia phenotypes. Next, the study asked if the tissue environment, specifically the amyloid plaques and neurofibrillary tangles characteristic of Alzheimer's disease, has any bearing on microglia's cellular and molecular phenotypes. QUIVER allowed the visualization of five molecular microglia/macrophage phenotypes using digital pathology tools. The recognizable reactive and homeostatic microglia/macrophage phenotypes demonstrated spatial polarization towards and away from amyloid plaques, respectively. Yet, microglia morphology appearance did not always correspond to molecular phenotype. This research not only sheds light on the biology of microglia but also offers QUIVER, a new tool for examining pathological alterations in the brains of the elderly.
Perioperative management of a patient with incidentally detected pulmonary artery aneurysm undergoing non-cardiac surgery—a case report
Authors: Shanker Bhawani , Alwardi Moosa Ahmed , Jagani Lalita , Yadav Ajay , Nair Abhijit 
Published: March 2023

Abstract
Background
There are few case reports in which non-cardiac surgery under regional anesthesia has been described in a patient with a pulmonary artery aneurysm. We report a case in which we managed a 74-year-old lady with a hip fracture for fixation under spinal anesthesia after thorough evaluation and meticulous planning. The patient was discharged home after 5 days without any perioperative events.

Case presentation
A 74-year-old, hypertensive lady with an incidentally detected pulmonary artery aneurysm was posted for a dynamic hip screw. Two-dimensional echocardiography revealed normal biventricular function with an ejection fraction of 60%, no regional wall motion abnormalities, concentric right ventricular hypertrophy (tricuspid annular plane systolic excursion or TAPSE of 19 mm), severe calcific pulmonary stenosis (PS) with pressures 90/61 mm Hg, pulmonary valve annulus of 12 mm, and pulmonary artery systolic pressure of 35 mm Hg. The left and right pulmonary artery diameters were 17 mm and 20 mm, respectively. She was clinically asymptomatic with an oxygen saturation of 98% on room air. A sequential lumbar epidural anesthesia was planned for this patient given her age, overall frail condition, and to avoid airway instrumentation. As epidural was difficult due to fused spaces, a sub-arachnoid block was administered with continuous monitoring. Surgery was uneventful and the patient was discharged on the 5th postoperative day.

Conclusions
With this case report, we suggest that a central neuraxial blockade could be administered in presence of severe PS with meticulous monitoring and careful planning.
Sublethal Hyperthermia Transiently Disrupts Cortisol Steroidogenesis in Adrenocortical Cells
Authors: Mullen Nathan , Donlon Padraig T , Sebek Jan , Duffy Katen , Cappiello Grazia , Feely Sarah , Warde Kate M , Harhen Brendan , Finn David P , O'Shea Paula M , Prakash Punit , O’Halloran Martin , Dennedy Michael C 
Published: March 2023

AbstractPrimary aldosteronism is the most common cause of secondary hypertension. The first-line treatment adrenalectomy resects adrenal nodules and adjacent normal tissue, limiting suitability to those who present with unilateral disease. Use of thermal ablation represents an emerging approach as a possible minimally invasive therapy for unilateral and bilateral disease, to target and disrupt hypersecreting aldosterone-producing adenomas, while preserving adjacent normal adrenal cortex. To determine the extent of damage to adrenal cells upon exposure to hyperthermia, the steroidogenic adrenocortical cell lines H295R and HAC15 were treated with hyperthermia at temperatures between 37 and 50°C with the effects of hyperthermia on steroidogenesis evaluated following stimulation with forskolin and ANGII. Cell death, protein/mRNA expression of steroidogenic enzymes and damage markers (HSP70/90), and steroid secretion were analyzed immediately and 7 days after treatment. Following treatment with hyperthermia, 42°C and 45°C did not induce cell death and were deemed sublethal doses while ≥50°C caused excess cell death in adrenal cells. Sublethal hyperthermia (45°C) caused a significant reduction in cortisol secretion immediately following treatment while differentially affecting the expression of various steroidogenic enzymes, although recovery of steroidogenesis was evident 7 days after treatment. As such, sublethal hyperthermia, which occurs in the transitional zone during thermal ablation induces a short-lived, unsustained inhibition of cortisol steroidogenesis in adrenocortical cells in vitro.
Tugendhat über Moralbegründung, Mystik und Religion
Authors: Steinvorth Ulrich 
Published: March 2023

AbstractTugendhat’s remarks on religion and mysticism are explored in section 5 and 6 of this paper. To this end I outline, in section 1, the role that the criticism of religion has played from its beginnings in philosophy’s self-understanding and its focus on reasoning, which philosophers opposed to the non-reasoning justification of religion. In section 2, I consider philosophy’s relation to empirical statements and to the empirical sciences; in section 3, I discuss Tugendhat’s substitution of anthropology for metaphysics; and in section 4, his moral theory.
Philosophie der Bionik: Das Komponieren von bio-robotischen Formen
Authors: Tamborini Marco 
Published: March 2023

AbstractIn this paper, I explore how bio-hybrid forms can be created and combined starting from organic forms. The thesis put forward is epistemological: the combinatorial practice of bionics, biomimetics, biorobotics, and all design strategies inspired by nature is not based on a kind of biomimetic inspiration, i. e., on a kind of imitation of nature, but on a practice of translation.To develop this thesis, I focus on the practices of contemporary biorobotics, first examining the practice of translating natural forms into technical artefacts as developed by Raoul Heinrich Francé at the beginning of the 20th century, secondly, analysing the production of robots capable of replicating complex locomotion systems and, finally, investigating the interaction between robots and living organisms (fish). In the last part of the paper, I reflect on the philosophical payoff and broader conditions of possibility for this translational practice. I discuss when and to what extent a translation of biological forms into biotechnical ones is acceptable and point out the notion of form that underlies this practice. Moreover, I draw attention to the need to philosophically investigate what happens between different domains of knowledge – and especially between science and technology. This article is thus an invitation to philosophers to develop a philosophy in the interstices of knowledge production.
Sokrates’ Verlegenheit(en)
Authors: Duc Viet Anh Nguyen 
Published: March 2023

Abstract
This article aims at conceptualising the notion of embarrassment as a negativistic figure of thought that takes the experience of one’s own non-sovereignty as a starting point and emphasises an engagement with situations of not-knowing. This consideration is clarified in discussion with the figure of Socrates or with the philosophical attitude of Socrates. Because the negativistic thrust of the conceptualisation undertaken is reminiscent of irony, the paper then addresses the question of what distinguishes embarrassment understood as a figure of thought from irony. For this purpose, Kierkegaard’s reading of Socratic irony is drawn upon. It is shown that irony is inherently a negativism, which in the last consequence aims at a retention of rights; but this is exactly what embarrassment avoids, because, as the article shows, it is not a negativism of strength, but of weakness.
Motivators for University of Professional Studies Accra Students to Adopt a Learning Management System in Ghana
Authors: Attuquayefio Samuel NiiBoi 
Published: March 2023

Abstract
The use of a learning management system (LMS) is believed to be significant for students’ academic performance, but students’ attitudes regarding its use are divided. Therefore, the purpose of this study is to apply a modified version of the technology acceptance model to determine the motivators for University of Professional Studies Accra students’ behavioural intentions (BIs) and actual use of LMSs using a convenient sampling technique to elicit data from first-year students in the faculty of information technology and communication studies. The investigation included a total of 188 samples. The study used structured equation modelling partial least squares to analyse the data. Specifically, the study employed the importance-performance map analysis to establish the factors that are important to students’ actual use of an LMS. The study’s findings suggest that REL and output quality significantly impact the perceived usefulness (PU). Also, perceived enjoyment and subjective norm exert a significant impact on the perceived ease of use (PEOU). Additionally, PEOU influences the PU, which in turn influences the BI. Furthermore, the findings reveal a strong link between BI and the actual use of the LMS. Finally, the study suggests that students’ BI to use the LMS is the most important factor for students’ actual use. PU is also an important determinant factor of students’ actual use. Following the study’s conclusion that BI and PU are important for students’ actual use of an LMS, higher education administrators must develop rules that increase the students’ PU of LMSs, while also ensuring that current measures that awaken students’ BIs are maintained or improved so that students can use the LMS for academic work.
Inguinal lymphadenectomy in penile cancer patients: a comparison between open and video endoscopic approach in a multicenter setting
Authors: Bada Maida , Crocetto Felice , Nyirady Peter , Pagliarulo Vincenzo , Rapisarda Sebastiano , Aliberti Antonio , Boccasile Stefano , Ferro Matteo , Barone Biagio , Celia Antonio 
Published: March 2023

Abstract

Objectives
To compare differences of operative outcomes, post-operative complications and survival outcomes between open and laparoscopic cases in a multicenter study.

Methods
This was a retrospective cohort study performed at three European centers from September 2011 to January 2019. The surgeon decision to perform open inguinal lymphadenectomy (OIL) or video endoscopic inguinal lymphadenectomy (VEIL) was done in each hospital after patient counselling. Inclusion criteria regarded a minimum follow-up of 9 months since the inguinal lymphadenectomy.

Results
A total of 55 patients with proven squamous cell penile cancer underwent inguinal lymphadenectomy. 26 of them underwent OIL, while 29 patients underwent VEIL. For the OIL and VEIL groups, the mean operative time was 2.5 vs. 3.4 h (p=0.129), respectively. Hospital stays were lower in the VEIL group with 4 vs. 8 days in OIL patients (p=0.053) while number of days requiring drains to remain in situ was 3 vs. 6 days (p=0.024). The VEIL group reported a lower incidence of major complications compared to the OIL group (2 vs. 17%, p=0.0067) while minor complications were comparable in both groups. In a median follow-up period of 60 months, the overall survival was 65.5 and 84.6% in OIL and VEIL groups, respectively (p=0.105).

Conclusions
VEIL is comparable to OIL regarding safety, overall survival and post-operative outcomes.
Lithium–lithium fusion evaporation research
Authors: Aksakal Hüsnü , Yıldız Ercan 
Published: March 2023

AbstractIn this study we have explored6Li + 7Li fusion evaporation reactions cross sections dependencies on both nuclear level density and various spin combination effects. The reaction cross section was calculated in the energy range of 0.1–16 MeV projectile of6Li on the fixed target of7Li. The excited compound nucleus (13C) can decay into various channels, and its decay rate in any given channel is proportional to the available phase space, i.e., the corresponding level density of it which is explained in the present study. In the present study, LISE++, PACE4, NRV and GEMINI codes were used to determine cross section of evaporation residues cross sections of13C.
The association between sleep duration, quality, and nonalcoholic fatty liver disease: A cross-sectional study
Authors: Liu Huiwei , Huang Shiliang , Xu Mengdan , Zhao Dan , Wang Xinxue , Zhang Liangshun , Chen Dahua , Du Jinman , Yu Rongbin , Li Hong , Ye Hua 
Published: March 2023

Abstract
Sleep can affect nonalcoholic fatty liver disease (NAFLD). We investigated the association between sleep duration, sleep quality, and NAFLD. From January to December 2018, 1,073 patients (age: 37.94 ± 10.88, Body Mass Index (BMI): 22.85 ± 3.27) were enrolled. Pittsburgh Sleep Quality Index Questionnaire and Munich Chronotype Questionnaire were used to assess sleep duration, quality, and habits. Ultrasonography was used to diagnose NAFLD. Multivariate logistic regression models were used to calculate the odds ratio (OR) and 95% confidence interval (CI) of the risk of NAFLD by different types of sleep duration and sleep quality. No significant differences in sleep time, sleep quality, and sleep habits between the NAFLD and the non-NAFLD groups were observed (P > 0.05). There was no correlation between sleep duration and NAFLD in the whole cohort. After adjusting for age, exercise, fasting plasma glucose, and BMI, the group with long sleep duration showed a decreased risk of NAFLD in men (OR = 0.01, 95% CI: 0.001–0.27, P = 0.032). However, in all four adjusted models, no correlation between sleep duration, quality, and NAFLD was found in women. In conclusion, sleep duration was significantly and negatively associated with NAFLD in men but not women. Prospective studies are required to confirm this association.
Blood and hair copper levels in childhood autism spectrum disorder: a meta-analysis based on case-control studies
Authors: Liu Hezuo , Huang Minhui , Yu Xiaomin 
Published: March 2023

Abstract

Objectives
The association between copper levels and autism spectrum disorder (ASD) has been a controversial topic. This study investigated relationship between copper levels and ASD.

Content
The following databases are searched until April 2022: PubMed, EMBASE and Web of Science. Combined effect size standardized mean differences (SMD) and 95% confidence intervals (95% CI) were calculated with Stata 12.0. In this meta-analysis, 29 case-control studies were included, which included 2,504 children with ASD and 2,419 healthy controls. The copper levels in hair (SMD: −1.16, 95% CI: −1.73 to −0.58) was significantly lower in ASD children than healthy controls. The copper levels in blood (SMD: 0.10, 95% CI: −0.12 to 0.32) not significantly compare ASD with controls.

Summary and outlook
Copper may be associated with the development of ASD in children.
Paradoxical kinesia may no longer be a paradox waiting for 100 years to be unraveled
Authors: Melo-Thomas Liana , Schwarting Rainer K. W. 
Published: March 2023

Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disorder mainly characterized by bradykinesia and akinesia. Interestingly, these motor disabilities can depend on the patient emotional state. Disabled PD patients remain able to produce normal motor responses in the context of urgent or externally driven situations or even when exposed to appetitive cues such as music. To describe this phenomenon Souques coined the term “paradoxical kinesia” a century ago. Since then, the mechanisms underlying paradoxical kinesia are still unknown due to a paucity of valid animal models that replicate this phenomenon. To overcome this limitation, we established two animal models of paradoxical kinesia. Using these models, we investigated the neural mechanisms of paradoxical kinesia, with the results pointing to the inferior colliculus (IC) as a key structure. Intracollicular electrical deep brain stimulation, glutamatergic and GABAergic mechanisms may be involved in the elaboration of paradoxical kinesia. Since paradoxical kinesia might work by activation of some alternative pathway bypassing basal ganglia, we suggest the IC as a candidate to be part of this pathway.