bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impulse Noise Suppression by Deep Learning-Based Receivers in OFDM System
Authors: Tseng Der-Feng , Lin Che-Shien , Tseng Shu-Ming 
Published: March 2023

Abstract
Due to inevitable corruption on signals across all subcarriers, strong and frequently occurring impulses pose a grim threat to Orthogonal Frequency Division Multiplexing (OFDM) systems, where system performance is likely to be further degraded by multipath fading phenomenon. Recently, a deep neural network (DNN) receiver is shown to be capable of not only implicitly estimating channel state information but also explicitly recovering the transmitted symbols without assuming the signal-to-noise ratio (SNR) level. In principle, the DNN model is trained using data generated from computer simulations–according to WINNER II channel model as fading channels, and the additive white Gaussian noise (AWGN) as background noise. As with its conventional peers which assume the inter- fering source from AWGN only, the aforementioned DNN receiver is prone to substantial performance loss when subject to impulse noise. To address this obstacle, this paper incor- porates the fine-tuning notion into the DNN model–by substituting impulse noise-laced data samples for succeeding training data–with an aim at enhancing representation learning. To attest the efficacy of the proposed DNN receiver, the bit error rate (BER) result derived from a compressive sensing-based receiver, enabled by consensus alternating direction method of multipliers (ADMM), is used as a benchmark for performance comparison. Noteworthily, the induced BER performance is comparable to that of the clipping-featured receiver, the threshold of which however solicits the knowledge of the SNR value, an assumption that is otherwise relaxed by the proposed DNN receiver. Furthermore, through extensive simulations, the deep learning based approach demonstrates promising robustness against impulse noise model mismatch between training and testing counterparts.
Resistance training decreases PCSK9 levels in patients undergoing phase II cardiac rehabilitation after coronary artery bypass grafting: A randomized study
Authors: Dwiputra Bambang , Santoso Anwar , Purwowiyoto Budhi Setianto , Radi Basuni , Ambari Ade Meidian 
Published: March 2023

Abstract
Background: Resistance training is recommended for post coronary by-pass artery graft (CABG) patients in addition to aerobic training as part of secondary prevention. However, there is a lack of studies that investigate the impact of resistance training on proprotein convertase subtilisin kexin 9 (PCSK9).
Aim: This study aims to assess the impact of intensive resistance training on PCSK9 level in post-CABG patients undergoing phase II cardiac rehabilitation.
Methods: In this randomized, prospective, open label trial, 87 post­CABG patients were assigned to moderate to high intensity resistance training and aerobic training (n=44) and aerobic training only (n=43) for 3­4 weeks. The primary endpoint was change of PCSK9 levels after cardiac rehabilitation program. Secondary endpoints include change of six-minute walk test (6-MWT) result, aerobic capacity, WHO­5 well­being index, fasting blood glucose and lipid profile. Intention-to-treat analysis was performed in both groups.
Results: After completion of phase II cardiac rehabilitation, mean PCSK9 levels in intervention group decreased significantly compared to control group (β=­55 ng/ml, 95%CI ­6.7 to ­103.3, p=0.026). This reduction was followed by significant improvement of 6-MWT result (β=28.2 m, 95%CI 2.4-53.9, p=0.033), aerobic capacity (β=0.9 Mets, 95%CI 0.1-1.7, p=0.021), and WHO­5 well­being index (β=8.1, 95%CI 2.0-14.4, p=0.011) in patients who performed resistance training in addition to aerobic training. There are no significant changes in fasting blood glucose, cholesterol, LDL­C, HDL-C, and triglyceride.
Conclusion: The addition of resistance training to aerobic training components in phase II cardiac rehabilitation significantly reduces PCSK­9 levels and increases patient’s functional capacity and quality of life. (NCT02674659)
Effect of amino acid supplementation on short-term complications after gastrointestinal tumor surgery: the AMIGITS randomized clinical trial
Authors: Wang Junke , Chen Yuezhi , Zhao Zhiwen , Lian Guodong Lian , Peng Lipan , Zhou Xinxiu , Sha Shengxu , Qiao Wenhao , Tian Hui , Li Leping , Tian Feng , Jing Changqing 
Published: March 2023

Abstract
There is a scarcity of large randomized clinical trials on the efficacy and safety of high-dose amino acid supplementation (AAS) in patients with gastrointestinal tumors undergoing surgical treatment. To investigate the effect of high-dose amino acid supplementation on the incidence of infection within 30 days after major surgery in patients with gastrointestinal tumors. In this randomized clinical trial, we randomly assigned patients with gastrointestinal tumors to receive either AAS or standard care (SC). The primary outcome was the 30-day postoperative incidence of infection; secondary outcomes included amino acid treatment-related adverse events, in-hospital infectious complications, postoperative hospital stay, other complications, and laboratory test results. We included 407 patients in the intention-to-treat analysis for the primary outcome (AAS group, 204; SC group, 203). During the intervention, the actual mean daily energy intake did not differ significantly between the AAS and SC groups (25.53 vs 25.16 kcal/kg daily, P = .493). However, the actual mean daily amino acid intake was significantly higher in the AAS group than in the SC group (1.81 vs. 0.94 g/kg daily, P < .001). The infection incidence within 30 days of surgery was significantly lower in the AAS group than in the SC group (P = .025). The incidence of amino acid treatment-related adverse events and other complications 30 days postoperatively did not significantly differ between the two groups. The infection incidence during hospitalization was significantly lower in the AAS group than in the SC group (P = .033). Compared to the SC group, the AAS group had significantly shorter postoperative hospital stays (P < .001). AAS is associated with a reduced infection incidence within 30 days of major surgery in patients with gastrointestinal tumors and can be a promising strategy. Trial registration: Chictr.org.cn, ChiCTR2200056258.
Case report: Infertility and pregnancy loss due to Intra-uterine Tuberculosis.
Authors: Stroeken Yaël , Broekhuijsen Kim , Leyten Eliane , Hermes Wietske 
Published: March 2023

Abstract
Tuberculosis (TB) is a disease with a high burden, with most patients in low and middle income countries (LMIC). In Western countries however, this disease is rare, but with the increasing number of migrants it becomes more relevant. Especially in women with fertility issues, TB is not the most likely diagnosis and therefore difficult to discover and treat. If TB is not detected at an early stage, it can have major consequences for fertility and pregnancy outcomes. Screening should be suggested in women originated from high endemic countries with unexplained fertility loss, or during first trimester screening. QuantiFERON testing and PCR sampling for TB should be the golden standard. This case report describes fertility issues and an immature delivery in a young woman caused by extrapulmonary TB in the genital tract. With this case report, we hope to draw attention to this disease so that early detection can take place and serious outcome can be prevented.
Research on the evaluation of heat resistance, sound insulation, economy and environmental protection performance of recycled plastic concrete based on the optimized proportion
Authors: wu haikuan , Kang Shun , zhang hangqi , Liu Changwu 
Published: March 2023

Abstract

With the rapid development of cities, the problem of environmental sustainability has become increasingly prominent, and it is increasingly important to build a socially resilient city. This research focuses on white pollution-the recycling of waste plastics in concrete in the city and the comfort of the urban living environment, from the perspective of concrete materials. Firstly, the proportion of recycled plastics, natural aggregate, water-cement ratio, and other parameters were optimized, and then the heat resistance, sound insulation, economic and environmental protection performance of the optimized concrete were studied. The results showed that the optimal proportion of recycled plastic concrete was obtained, and the strength deterioration mechanism was revealed. The maximum suitable use temperature of recycled plastic concrete is around 75 ℃. Recycled plastic concrete has better sound insulation performance for unsteady sound, human sound and mechanical sound. In terms of economic and environmental performance, the cost of raw materials of recycled plastic concrete is not dominant, and the water-soluble extracts have little impact on the environment. The research results are expected to provide a theoretical basis for the realization of urban environmental sustainable development.
The nature of psychiatric problems in Primary health Care centers: the experience of a Community Mental Health Center in northeast of Iran
Authors: Talebi Mahdi , Nemati Ahmad , Gholami Mobin , Niroumand Shabnam 
Published: March 2023

Abstract
Background
Community Mental Health Centers (CMHCs) provide mental health services to patients at low cost, with less stigma, in a domiciliary. This is the first study to describe demographic characteristics, common mental disorders, referral status, and treatment discontinuation in patients at the only CMHC of Mashhad, northeastern Iran.
Methods
This cross-sectional study enrolled 662 patients who contacted this center between January 2014 and December 2021. We completed a checklist that included information on demographics, diagnosed mental disorders, referral status, and the number of psychiatric visits, all of which psychiatrists fully completed clinical records. The frequency distributions of all variables were carried out with SPSS11.5. In addition, the association between epidemiological findings and patient referral (referral system or self-referral) and the association between epidemiological findings and the number of psychiatric visits were examined by the Chi-square test.
Results
Of 662 patients, 472 (71%) women and 190 (29%) men were enrolled, and the mean age of all patients was 29 years. Among the 475 adult patients, 367 (77.3%) patients were married and had primary or secondary education (40.4%), and the majority of them were housewives (56.4%). Major Depression Disorder (32%), Generalized Anxiety Disorder (18.3%) were the two most common mental illnesses in patients. Large proportions of the patients (70.7%) were referred to this center via the referral system. Moreover, non-working patients (housewives and unemployed patients) and the female gender were associated with more referrals to this center through the referral system. 431 patients (65.1%) did not return for a second visit, and the higher number of psychiatric visits was associated with a lower level of education.
Conclusions
Based on the results of this study, most of the patients in this center had a low socioeconomic level. Most of them were referred through the referral system, and gender and employment significantly contributed to referral via the referral system. The majority of patients discontinued treatment after the first psychiatric visit, and this was associated with the level of education.
An Empirical Study of npm Ecosystem Related Tweets by Core Software Developers: A Case Study
Authors: Islam Syful , Nugroho Yusuf Sulistyo , Shahrear Akib , Wahed Nuhash , Gunawan Dedi , Pamungkas Endang Wahyu , Kabir Mohammed Humayun , Kurniawan Yogiek Indra 
Published: March 2023

Abstract
npm ecosystem is crucial for the JavaScript community and its development is significantly influenced by the opinions and feedback of core software developers.Many software developers have utilized social media, such as Twitter, to share community-related information and their views. However, the communication between npm developers via Twitter in terms of topics, nature, and sentiment have not been analyzed.This study conducts an empirical analysis of tweets by core software developers related to the npm ecosystem to understand their perceptions and opinions better. A dataset of tweets was collected and analyzed using qualitative analysis techniques to identify the topic of tweets, their nature and their sentiments. Our study demonstrated that most tweets belong to the package management category followed by notifications and community-related information.The most frequently discussed topics among core software developers in the package management category are usage scenarios. It appears that developers use a variety of approaches, with information tweets dominating, followed by questions and answers.Additionally, the sentiment analysis revealed that developers express more positive sentiments towards notification and community-related discussion while expressing more neutral opinions towards the package ecosystem discussion category. This case study provides valuable insights into the perceptions and opinions of core software developers regarding the npm ecosystem and can inform future development and decision-making.
Diagnostic yield and novel candidate genes for neurodevelopmental disorders by exome sequencing in an unselected cohort with microcephaly
Authors: Wang Chunli , Zhou Wei , Zhang Luyan , Fu Luhan , Shi Wei , Qing Yan , Lu Fen , Tang Jian , Gao Xiucheng , Zhang Aihua , Jia Zhanjun , Zhang Yue , Zhao Xiaoke , Zheng Bixia 
Published: March 2023

Abstract
Objectives: Microcephaly is caused by reduced brain volume and most usually associated with a variety of neurodevelopmental disorders (NDDs). To provide an overview of the diagnostic yield of whole exome sequencing (WES) and promote novel candidates in genetically unsolved families, we studied the clinical and genetic landscape of an unselected Chinese cohort of patients with microcephaly.
Methods: We performed WES in an unselected cohort of 103 NDDs patients with microcephaly as one of the features. Full evaluation of potential novel candidate genes was applied in genetically undiagnosed families. Functional validations of selected variants were conducted in cultured cells. To augment the discovery of novel candidates, we queried our genomic sequencing data repository for additional likely disease-causing variants in the identified candidate genes.
Results: In 71 families (68.9%), causative sequence variants (SVs) and clinically relevant copy number variants (CNVs) were identified. By incorporating coverage analysis to WES, a pathogenic or likely pathogenic CNV was detected in 15 families (16/103, 15.5%). In another eight families (8/103, 7.8%), We identified eight novel neurodevelopmental disorders /microcephaly candidate genes, which involved in cell cycle and division (PWP2, CCND2), CDC42/RAC signaling related actin cytoskeletal organization (DOCK9, RHOF), neurogenesis (ELAVL3, PPP1R9B, KCNH3) and transcription regulation (IRF2BP1). By looking into our data repository of 5066 families with NDDs, we identified additional two cases with variants in DOCK9 and PPP1R9B, respectively.
Conclusion: Our results expand the morbid genome of monogenic neurodevelopmental disorders and support the adoption of WES as a first-tier test for individuals with microcephaly.
Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine
Authors: Yu Peng , Li Mingyuan , Jia Lin , Xie Yanbo , Ma Wenlin , Yan Zhihong , Ma Yuman , Deng Jie , Zhu Ali , wei Xue Si , Su Wen , Liu XiaoFeng , Li Shiqin , Wang Haomeng , Zhu Tao 
Published: March 2023

Abstract
Some studies have shown that lyophilization significantly improves the stability of mRNA-LNPs and enables long-term storage at 2–8 ℃. However, there is little research on the lyophilization process of mRNA-lipid nanoparticles (LNPs). Most previous studies have used empirical lyophilization with only a single lyoprotectant, resulting in low lyophilization efficiency, often requiring 40–100 h. In the present study, an efficient lyophilization method suitable for mRNA-LNPs was designed and optimized, shortening the total length of the lyophilization process to 8–18 h, which significantly reduced energy consumption and production costs. When the mixed lyoprotectant composed of sucrose, trehalose, and mannitol was added to mRNA-LNPs, the eutectic point and collapse temperature of the system were increased. The lyophilized product had a ginger root-shaped rigid structure with large porosity, which tolerated rapid temperature increases and efficiently removed water. In addition, the lyophilized mRNA-LNPs rapidly rehydrated and had good particle size distribution, encapsulation rate, and mRNA integrity. The lyophilized mRNA-LNPs were stable at 2–8 ℃, and they did not reduce immunogenicity in vivo or in vitro. Molecular dynamics simulation was used to compare the phospholipid molecular layer with the lyoprotectant in aqueous and anhydrous environments to elucidate the mechanism of lyophilization to improve the stability of mRNA-LNPs. This efficient lyophilization platform significantly improves the accessibility of mRNA-LNPs.
Investigation the effect of nano carbon tube prepared from tea waste on Microstructure and properties of cement mortar
Authors: Biajawi Mohammad I. Al , Abdulrahman May F. , Saod Wahran M. , Hilal Nahla , Embong Rahimah , Sor Nadhim Hamah 
Published: March 2023

Abstract
Environmental contamination and the massively higher cost of disposal of wastes have been a big concern for scholars throughout the globe, prompting them to seek a way to recycle waste materials in various implementations filed. The rising expenditure of disposal and the shortage of naturally big aggregate have increased interest in reusing recycled waste materials to manufacture concrete and mortar. The some of the country population annually consumes hundreds of tonnes of black tea, resulting in a considerable number of discarded teabags. These huge quantities are disposed of in landfills without being recycled or otherwise used. Moreover, landfills are considered one of the country's biggest global issues. Therefore, the aim of this experimental work to investigate influence of nano carbon tube produced from tea waste as cement replacement materials in mortar mixtures. Cement mortar mixes contain four replacement levels (1%, 2%, 3%, and 4%) of cement with nano carbon tube produced from tea waste. The compressive strength, ultrasonic pulse velocity, and water absorption were tested to demonstrate the effect of the nano carbon tube made from recycled tea waste on the mechanical properties of the mortar mix. The fresh properties such as flow rate were evaluated in accordance with the specific standards. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDX) analyses were performed to demonstrate the microstructure of the mixtures. The results show that the fresh properties (flowability) of mortar containing nanocarbon tubes from tea waste were improved with the increase of the replacement ratio. In addition, the compressive strength was improved by substitution of up to 2%. For the other levels of substitution, it decreased with increasing proportion. In contrast, the density was increased with the increase in the substitution level of tea waste. Based on the results of the experiments, it seems that the suggested bio-mixture could increase the compressive strength of the material by up to 2% of the replacement at 28 days of curing.
Crenolanib inhibits retinal fibrosis associated with resistance to anti-VEGF in neovascular age-related macular degeneration in retinal Müller cells
Authors: Joo Jin-Ho , Chung Junkyu , Seo Jung-Woo , Moon Sang Woong 
Published: March 2023

Abstract
Backgorund
Anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (NVAMD) may cause fibrosis in primary cultured mouse retinal Müller cells (PMCs), resulting in resistance to treatment. This study aimed to confirm the decrease in the expression of fibrosis-related proteins after treatment with platelet-derived growth factor receptor (PDGFR) inhibitor.
Methods
PMCs were treated with anti-VEGF, bevacizumab, and PDGF, for 24 and 72 h, and the expression of fibrosis-related proteins, inflammatory cytokines, and PDGFR was confirmed. After 72 h of co-treatment of PMCs with bevacizumab and crenolanib, a PDGFR inhibitor, fibrosis-related protein expression was confirmed.
Results
When PMCs were treated with 1 mg/mL bevacizumab for 72 h, the expression of VEGF and inflammatory cytokines decreased, and the expression of fibrosis-related proteins and PDGFR-β increased. When PMCs were treated with 100 ng/mL PDGF-B for 72 h, the expression of VEGF and inflammatory cytokines increased, and the expression of fibrosis-related proteins and PDGFR-β decreased. When PMCs were treated with 1 mg/mL bevacizumab and 5 nM crenolanib, the expression of fibrosis-related proteins decreased.
Conclusion
If PMCs are treated with anti-VEGF agents for a long time, fibrosis may occur that may lead to resistance to NVAMD treatment. When PMCs are treated with anti-VEGF and crenolanib, a PDGFR inhibitor, the expression of fibrosis-related proteins is reduced.
Research on Key Acoustic Characteristics of Soundscapes of the Classical Chinese Gardens
Authors: Chen Wei , Liu Juanjuan 
Published: March 2023

Abstract
Soundscapes have played an important role in the design and building of classical Chinese gardens. In Chinese classical poetry, biophonies such as bird calls, and geophonies such as wind, are the preferable sound sources. Although these major sound sources have been categorized and summarized by scholars extensively, little research has been conducted to analyze the physical characteristics and preference matrix of these preferred sound sources. Moreover, the perceived loudness of sound in classical Chinese gardens has received more attention from scholars than acoustic frequency. In this study, we selected 12 sound sources that are most typically present in classical Chinese gardens based on extensive literature research on Chinese classical poetry, and acquired respective audio samples from the BBC’s library of Sound Effects. Through the spectrogram analyses, pitch detection algorithm and LSTM audio classification methods, the sound sources were classified into discrete sound sources with pitch variation and continuous sound sources with spectral characteristics of white noise or pink noise. The reasoning behind the preference for these two types of sound sources was then discussed from physical and mental healing perspectives, which aims to help provide perspectives on the associated implications in the planning of urban green spaces.
Atomic Delocalization in Solar Flare Heavy-Ion Tracks and Its Impact on the Plastic Deformation of CE-5 Lunar Soil
Authors: Chen Yujie , Fang Yan , Fu Xiaoqian , Guo Jiangang , Ying Tianping , Ding Jun , Liu Suya , Yang Guang , GU Lin , Bo Zheng , Zhang Ze , Chen Xiaolong , Li Jinhua , Yu Qian 
Published: March 2023

Abstract
Understanding the impact of space weathering on the mechanical properties of materials can provide strong implications for the exploration of the space including the building of a permanent base on airless planets. By examining the structure of solar flare tracks, which exist prevalently in lunar soils returned by Chang’e-5 mission, we revealed that the solar flare tracks are nanosized tubular defects where the silicon and oxygen atoms are delocalized. They are created by implantations of particles with atomic number larger than vanadium. The solar flare tracks first function as dislocation sources and act as strong hindrance for dislocation motions subsequently, resulting in dislocation multiplication and strain hardening. These changes make the mechanical properties of lunar soil significantly distinct from its counterpart residing on the Earth.