bluuebunny/crossref_metadata_2025_split huggingface dataset:
A follow up on the feasibility after national implementation of magnesium sulfate for neuroprotection prior to preterm birth
Authors: Hellström Sara , Jonsdotter Andrea , Jonsson Maria , Pettersson Karin , Saltvedt Sissel , Herbst Andreas , Ågren Johan , Ådén Ulrika , Domellöf Magnus , Hagberg Henrik , Carlsson Ylva 
Published: September 2023

AbstractIntroductionThe risk for brain injury manifested as cerebral palsy is higher in very preterm born children than in term. Prenatal administration of magnesium sulfate (MgSO4) has been shown to be neuroprotective and reduces the proportion of very preterm born children later diagnosed with cerebral palsy. A Swedish national clinical practice guideline was implemented in March 2020, stipulating the administration of a single intravenous dose of 6 g MgSO4 1–24 h prior to delivery before gestational age 32+0, aiming for 90% treatment coverage. The aim of this study was to evaluate the feasibility of this new clinical practice guideline in the first year of its implementation.Material and methodsData on MgSO4 treatment were collected by reviewing the medical charts of women who gave birth to live born children in gestational age 22+0–31+6 during the period of March 1, 2020 to February 28, 2021, at five Swedish university hospitals. Women with pre‐eclampsia, eclampsia, or high elevated liver enzymes low platelets (HELLP) were excluded.ResultsA total of 388 women were eligible and 79% received treatment with MgSO4. Of the 21% not receiving treatment, 9% did not receive treatment due to lack of knowledge about the clinical practice guideline, 9% were not possible to treat and 3% had missing data. The proportion treated increased from 72% to 87% from the first to the last 3 months. Of those treated, 81% received the drug within the stipulated timeframe (mean 8.7 h, median 3.4 h).ConclusionsThere was a positive trend over time in the proportion of women receiving MgSO4 treatment, but the a priori target of 90% was not reached during the first year of implementation. Our findings indicate that this target could be reached with additional information to clinicians.
Firm heterogeneity in competition among the big and the small
Authors: Fujiwara Kenji 
Published: September 2023

AbstractThis paper makes comparative statics in a model in which oligopolistic and monopolistically competitive firms that are heterogeneous in productivity compete. We demonstrate that (i) entry of oligopolistic incumbents, (ii) reduction in entry cost of monopolistically competitive entrants, and (iii) market size expansion improve the average productivity in the whole economy. However, (i) and (iii) raise welfare, but (ii) may lower welfare because of the presence of oligopolistic firms.
The role of NMDARs in the anesthetic and antidepressant effects of ketamine
Authors: Zhou Liang , Duan Jingjing 
Published: September 2023

AbstractBackgroundAs a phencyclidine (PCP) analog, ketamine can generate rapid‐onset and substantial anesthetic effects. Contrary to traditional anesthetics, ketamine is a dissociative anesthetic and can induce loss of consciousness in patients. Recently, the subanaesthetic dose of ketamine was found to produce rapid‐onset and lasting antidepressant effects.AimHowever, how different concentrations of ketamine can induce diverse actions remains unclear. Furthermore, the molecular mechanisms underlying the NMDAR‐mediated anesthetic and antidepressant effects of ketamine are not fully understood.MethodIn this review, we have introduced ketamine and its metabolism, summarized recent advances in the molecular mechanisms underlying NMDAR inhibition in the anesthetic and antidepressant effects of ketamine, explored the possible functions of NMDAR subunits in the effects of ketamine, and discussed the future directions of ketamine‐based anesthetic and antidepressant drugs.ResultBoth the anesthetic and antidepressant effects of ketamine were thought to be mediated by N‐methyl‐D‐aspartate receptor (NMDAR) inhibition.ConclusionThe roles of NMDARs have been extensively studied in the anaesthetic effects of ketamine. However, the roles of NMDARs in antidepressant effects of ketamine are complicated and controversial.
Identifying the common elements of psychological and psychosocial interventions for preventing postpartum depression: Application of the distillation and matching model to 37 winning protocols from 36 intervention studies
Authors: Lin Yuping , Zhang Xiangchun , Zhou Tianchun , Xu Feng , Zhu Xinli , Zhou Huixin , Wang Xiao , Ding Yan 
Published: September 2023

AbstractAimPostpartum depression is prevalent worldwide and seriously endangers maternal and child health. Previous studies have demonstrated the effectiveness of psychological and psychosocial intervention programmes in preventing postpartum depression. However, the literature offers limited practice guidance. Therefore, this study aimed to deeply analyse prior findings to gather rich evidence‐based information on this topic.MethodsUsing the distillation and matching model, we conducted a systematic review of psychological and psychosocial interventions used to effectively prevent postpartum depression. Four researchers trained in coding system independently read eligible studies and identified reliable (Cohen's kappa >0.40) and frequently occurring (frequency ≥3 winning study groups) practice elements.ResultsOur review included 36 studies containing 37 winning study groups. Fourteen practice elements were identified and subsequently divided into six categories: postpartum practical problems‐related, social support‐related, interpersonal psychotherapy‐related, cognitive behavioural therapy‐related, labour trauma‐related and non‐specific techniques. The most common practice elements were baby care skills and mother–infant bonding/interaction enhancement. Inter‐rater reliability averaged 0.86, ranging from 0.48 to 1.ConclusionThe practice elements identified in this study provide rich evidence‐based information that can guide clinical practitioners in selecting or developing effective, realistically available intervention programmes.
SerpinA1 levels in amyotrophic lateral sclerosis patients: An exploratory study
Authors: Martinelli Ilaria , Zucchi Elisabetta , Simonini Cecilia , Gianferrari Giulia , Bedin Roberta , Biral Chiara , Ghezzi Andrea , Fini Nicola , Carra Serena , Mandrioli Jessica 
Published: September 2023

AbstractBackgroundSerpinA1, a serine protease inhibitor, is involved in the modulation of microglial‐mediated inflammation in neurodegenerative diseases. We explored SerpinA1 levels in cerebrospinal fluid (CSF) and serum of amyotrophic lateral sclerosis (ALS) patients to understand its potential role in the pathogenesis of the disease.MethodsSerpinA1, neurofilament light (NfL) and heavy (NfH) chain, and chitinase‐3‐like protein‐1 (CHI3L1) were determined in CSF and serum of ALS patients (n = 110) and healthy controls (n = 10) (automated next‐generation ELISA), and correlated with clinical parameters, after identifying three classes of progressors (fast, intermediate, slow). Biomarker levels were analyzed for diagnostic power and association with progression and survival.ResultsSerpinA1serum was significantly decreased in ALS (median: 1032 μg/mL) compared with controls (1343 μg/mL) (p = 0.02). SerpinA1CSF was elevated only in fast progressors (8.6 μg/mL) compared with slow (4.43 μg/mL, p = 0.01) and intermediate (4.42 μg/mL, p = 0.03) progressors. Moreover, SerpinA1CSF correlated with neurofilament and CHI3L1 levels in CSF. Contrarily to SerpinA1CSF, neurofilament and CHI3L1 concentrations in CSF correlated with measures of disease progression in ALS, while SerpinA1serum mildly related with time to generalization (rho = 0.20, p = 0.04). In multivariate analysis, the ratio between serum and CSF SerpinA1 (SerpinA1 ratio) and NfHCSF were independently associated with survival.ConclusionsHigher SerpinA1CSF levels are found in fast progressors, suggesting SerpinA1 is a component of the neuroinflammatory mechanisms acting upon fast‐progressing forms of ALS. Both neurofilaments or CHI3L1CSF levels outperformed SerpinA1 at predicting disease progression rate in our cohort, and so the prognostic value of SerpinA1 alone as a measure remains inconclusive.
Called to Transformation
Authors: Pillay Jerry 
Published: September 2023

AbstractAgainst the background of the document Called to Transformation – Ecumenical Diakonia, published in June 2022 by the World Council of Churches and ACT Alliance, this article argues for a comprehensive approach to diakonia in which community projects and programmes, education, and training should emphasize social justice, people's participation, and the role of people's movements and the need for networking between them. This approach also stresses that diakonia must go beyond mere service, charity, and relief and engage in radical transformation.
Using questionnaires as conversational tools to bolster the therapeutic alliance in family therapy practice
Authors: Rober Peter , Van Tricht Karine 
Published: September 2023

AbstractIn this clinical paper, the focus is on the use of questionnaires in family therapy practice. Psychotherapy research has indicated that the quality of the therapeutic relationship is the most robust predictor of therapeutic change. While the therapeutic relationship is even more important in family therapy than in individual therapy, it is also more complex. As will be illustrated in this paper, questionnaires can be useful in clinical practice to deal with the complex alliances in family therapy. In this paper, we will introduce two questionnaires: the Worries Questionnaire and the Dialogical Feedback Questionnaire. As illustrated in detailed case stories, we use these questionnaires in our practice as conversational tools rather than measuring instruments. They serve as the starting point for the therapist's reflection and for dialogues with family members.
MEDIEVALISMS AND MEDIEVAL TIMES: CONFRONTING CHRONOPOLITICS WITH MEDIEVAL TEXTURES OF TIME
Authors: Skoda Hannah 
Published: September 2023

ABSTRACTThis review essay examines Nadia R. Altschul's discussion of medievalism in nineteenth‐ and twentieth‐century South America in Politics of Temporalization: Medievalism and Orientalism in Nineteenth‐Century South America. She explores a chronopolitics whereby the notion that late medieval Iberia lagged developmentally behind the rest of Europe sustained the claim that parts of South America were still medieval, even while capitalist modernity was established elsewhere. Her exploration of the instrumentalization of this trope for neocolonial and neoliberal purposes provokes my own exploration here of medieval ideas about time. Medieval people actually had very sophisticated ideas about time, and this complexity troubles the idea of a simplistic and dully repetitive medieval temporality on which the linear hierarchies of time analyzed and critiqued by Altschul rely. More than this, though, I suggest that medieval ideas of time provide us with alternative chronotopes in the sense of thinking through the relationships between time and space in very different ways; in turn, this might permit a different kind of chronopolitics. First, I explore the ways in which medieval people experienced and articulated multiple interwoven layers of time, de‐essentializing hierarchies of temporalities and puncturing the illusion that certain spaces should be associated with certain times. Second, I look at the ways in which time was not straightforwardly conceived of as linear in the Middle Ages and consider the ways in which this troubles ideas of periodization; a short discussion of nostalgia in different periods sustains this point. Third, I explore the ways in which ideas about time could be contested in the Middle Ages, challenging the idea that chronopolitics need just be a study of hegemonic attitudes.
Brushing behaviour changes and plaque removal with an electric toothbrush: A clinical trial
Authors: Adam Ralf , Zou Yuanshu , Grender Julie , Mesples Uta , Erb Jasmin , Bray Kimberly 
Published: September 2023

AbstractObjectiveTo evaluate changes in toothbrushing behaviour and plaque removal performance with usage of a next generation oscillating‐rotating electric toothbrush (NG‐OR).MethodsThis exploratory clinical study had a two‐treatment, three‐period, single‐group, sequential design. Generally healthy adults with a screening whole mouth mean Turesky modified Quigley‐Hein Plaque Index (TQHPI) score of at least 1.75 on a 0–5 scale and who were primarily OR brush users were enrolled. Participants used each OR toothbrush in A‐B‐B order, where a currently marketed OR brush with a traditional mechanical drive system (T‐OR) was used in period A, and the NG‐OR brush with a linear magnetic drive was used in period B. At Visit 1, qualifying participants brushed on‐site with T‐OR. After a 48 h washout, participants returned for Visit 2 and brushed on‐site with NG‐OR. Participants then used NG‐OR for 1 week, twice daily, at home and returned for Visit 3 to brush on‐site with NG‐OR again. For all on‐site brushings, participants were instructed to brush for 2 min without interactive features. Each toothbrush was tagged with a transmitter chip connected to a Motion Tracking System to record movements of the toothbrush and participant using infrared light transmission to determine Isochronicity (brushing time uniformly distributed across the dentition). Plaque was measured using TQHPI. Primary variables were Isochronicity and TQHPl whole mouth mean plaque reduction (pre‐brushing minus post‐brushing).ResultsOverall, 41 participants enrolled and received treatment; 40 completed the trial. NG‐OR showed significantly greater Isochronicity after a single brushing (p = 0.043) and after a 1‐week at‐home use (p = 0.001) versus T‐OR. NG‐OR showed 41% greater whole mouth plaque removal than T‐OR (p < 0.001) after a single brushing. Plaque reduction by region/surface was consistent with whole mouth results.ConclusionThe NG‐OR brush showed greater brushing uniformity and plaque removal versus the T‐OR brush.
Enterocin AS‐48 inhibits the growth of – and biofilm formation by – lactic acid bacteria responsible for the accumulation of biogenic amines in cheese
Authors: Sarquis Agustina , Villarreal Luis Alberto , Ladero Victor , Maqueda Mercedes , del Rio Beatriz , Alvarez Miguel A. 
Published: September 2023

SummaryCheese is a fermented food in which toxic concentrations of biogenic amines (BAs) may accumulate, mainly as a result of the metabolism of certain lactic acid bacteria (LAB); the formation of these compounds needs to be limited. This work reports the antimicrobial potential of bacteriocin AS‐48 against the LAB largely responsible for the accumulation of the BA histamine, tyramine and putrescine in cheese. Most of the 50 analysed BA‐producing LAB strains were sensitive to AS‐48. The bacteriocin also prevented biofilm formation of 92% of the BA‐producing strains tested. This result is of great technological importance since, in cheese production, biofilms are an important source of contamination by BA‐producing LAB. This study supports the potential use of AS‐48 as a biopreservative for controlling BA‐producing LAB in fermented food.
The texture factor: food product development for discrete populations including orally compromised elderly consumers and children with Down syndrome
Authors: Ross Carolyn F. 
Published: September 2023

SummaryIn the development of food products with optimised nutritional and sensory properties, the emphasis is often placed on the nutrient content of the food rather than the texture of the food. The objective of this short opinion piece is to argue that texture should be considered an integral property of a personalised food, considering two case studies. The first case study profiles older adults, a broad group who often experience an unwanted decrease in food texture variety in their diets, with associated negative health outcomes. The second case study examines children with Down syndrome who confront the task of expanding their food texture repertoire to allow for a healthy eating future but face challenges in texture handling due to delays in oral processing development. Following an overview of the texture challenges facing each of these groups, the importance of extending research to partner with the food industry to develop food products with desired texture properties and appropriate food structure is presented.
Influence of extruded whole wheat flour addition on quality characteristics of pasta
Authors: Kaur Harmandeep , Bobade Hanuman , Sharma Rajan , Sharma Savita 
Published: September 2023

SummaryThis work aimed to develop the whole wheat (common) flour pasta by incorporation of whole wheat flour modified by extrusion process at various percentages and assess the effect of modified extruded whole wheat flour (EWWF) on quality characteristics of pasta. The whole wheat flour was modified by extruding it at 15% feed moisture, 148 °C extrusion temperature and 434 rpm screw speed through a twin screw extruder. The modified EWWF was added to the whole wheat flour at a 10%–40% substitution level with whole wheat flour for the preparation of pasta and its quality was compared against the semolina pasta and pasta prepared from whole wheat flour. The study characterized the functional, antioxidant properties, in vitro starch and protein digestibility, cooking parameters and colour properties of the EWWF pasta. Extrusion increased the water absorption, water solubility and oil absorption characteristics of EWWF. The total phenolic content (TPC) and total flavonoid content (TFC) of pasta (0%—40%) ranged from 170.07 to 146.04 mg GAE/100 g and 156.00 to 137.60 mg CE/100 g, respectively, compared to the semolina pasta. The antioxidant properties of the EWWF pasta decreased after the incorporation of extruded flour. The pasta prepared with the incorporation of 40% EWWF showed the best cooking properties. The colour of EWWF pasta turned darker compared to semolina pasta. The pasta prepared with the use of EWWF could be utilized as a healthy alternative to the existing pasta in India.
TiNbO4‐coated industrial submicron Si anode for high‐performance Li‐ion batteries
Authors: Ma Yangzhou , Li Haoduo , Li Qi , Zhou Jingwei , Cai Zhenfei , Wang Shuai , Yu Mo , Liu Cheng , Song Guangsheng , Wen Cuie 
Published: September 2023

AbstractSilicon (Si) is a promising anode material for Li‐ion batteries but suffers from volume change during (de)lithiation, leading to electrode pulverization and capacity decay. To address this issue, we introduced a zero‐strain Li‐ion conductor TiNbO4 (TNO) coating on the surface of industrial submicron Si using a simple precipitation method. The density functional theory calculation confirmed TNO as an excellent coating layer to alleviate silicon expansion and benefit to the Li diffusion. The resulting compounds were characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscope, X‐ray photoelectron spectroscopy, half‐cell charge–discharge tests, and cyclic voltammetry and showed that amorphous TNO was well distributed on the Si particles and can effectively improve the Si anode's cycle performance. After 120 cycles, the TNO‐coated Si anode retained 565 mA h g−1 capacity under 0.1 C, which is better than that of pure Si with less than 100 mA h g−1.
A Reflection on Dialogic Diving Boards and Decolonising School Art: The African Mask Project
Authors: Grant Will , Richards Malcolm , Steward Ros , Whelan Jamie 
Published: September 2023

AbstractIn this paper, four colleagues working in teacher education reflect on a conversation. The conversation in question was a tangible discussion documented through frequent and purposeful email exchange, exploring traditionalist school art curricula through reference to lived experience, academic theory, and professional anecdote. The primary objective of this dialogic self‐enquiry was informal critical analysis of the cultural diversity and positioning of art objects that populate classroom curricula in English schools, starting with the ‘African mask’. The secondary objective of our conversation was exploration of how complex talk on culture and curriculum might be modelled for schoolteachers yet to initiate similar conversations in their own professional contexts. We each provide reflections on the success of our conversation against these objectives and find that while email exchange provided some formal advantages for the structure of our discourse, this was not as we might have expected. The dialogue facilitated a rhizomatic deepening of our individual questioning of culturality in the classroom, which while nourishing was arguably unproductive in instrumental terms. Collectively, our reflections suggest that dialogue may be a critical catalyst for the latter, inherently private work of decolonising one's own critical teaching praxis.
The involvement of transient receptor potential channels in mast cell activation by microbubbles
Authors: Liu Jia , Qing Long , He Yufei , Zhu Qihui , Xu Weigang , Wu Jianhua 
Published: September 2023

AbstractThis study was to explore the activation of mast cells by microbubbles, with the focus on transient receptor potential (TRP) channels mediated degranulation and calcium influx. Bone marrow‐derived mast cells (BMMCs) were primarily obtained from femurs in mice and induced differentiation for 4 weeks. After the purity identification, BMMCs were contacted by homogeneous microbubbles with the diameter of 1 mm for 1 h. β‐hexosaminidase and histamine levels in supernatants were assessed by enzyme‐linked immunosorbent assay (ELISA) and the CD63 expression was tested by flow cytometry. The intracellular calcium binding with Fluo‐4 AM dyes in BMMCs was observed under the fluorescence microscope and the mean fluorescence intensity was quantitatively measured by flow cytometry. β‐hexosaminidase release, histamine concentration, CD63 expression and calcium influx were significantly increased in BMMCs group upon microbubble stimulation compared to the control groups. After preconditioning with the available inhibitors and microbubble contact, only transient receptor potential vanilloid 1 (TRPV1) and TRPV4 inhibitors robustly suppressed the microbubble‐induced degranulation. Likewise, the elevated fluorescence intensity of cytosolic calcium level was also significantly weaken. The results demonstrated microbubble stimulus effectively promoted BMMCs degranulation, which could be substantially restrained by inhibitors targeted for blocking TRPV1 or TRPV4 channel. The alternation of intracellular calcium level in BMMCs was consistent with the changes of degranulation capacity. It's suggested that the activation of BMMCs by microbubbles may involve specific TRP calcium dependent channels.