bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoción turística digital de España en China: estudio de caso de la cuenta de Turespaña en WeChat
Authors: Zhang Leticia-Tian , Yu Qinwen 
Published: February 2023

ResumenLa promoción turística se vuelve cada día más digital y sofisticada. El presente estudio se centra en el Instituto de Turismo de España (Turespaña) y pretende identificar, analizar y evaluar las herramientas y estrategias del marketing turístico presentes en sus publicaciones en una de las plataformas digitales más utilizadas en China, WeChat, teniendo en cuenta la reacción y participación de los usuarios. Utilizando el estudio de caso y el análisis de contenido, se recoge un total de 90 artículos del año 2020 publicado por Turespaña, se categorizan los temas tratados y se examinan los recursos multimodales adoptados. Los resultados revelan una diversidad de temas (naturaleza, ciudades, compras, comida, festivales, cultura y arte, arquitectura, deporte, consejos de viaje, temáticas y noticias), en la que el contenido relacionado a ciudades y comida interesa más al público chino, mientras las temáticas y noticias atraen menos atención, a pesar de su frecuencia elevada de publicación. Sobre las herramientas, Turespaña acude principalmente a la inserción de vídeos, acogida por la audiencia china, pero apenas organiza concursos o sorteos. Partiendo de los referidos procedimientos, se plantean varias sugerencias para mejorar la promoción turística digital del organismo y satisfacer las nuevas necesidades de los jóvenes turistas chinos.
Characteristics of anemia in heart failure: iron metabolism, erythropoietic activity and markers of inflammation
Authors: Gurkina A. A. , Stuklov N. I. , Kisly N. D. , Gimadiev R. R. , Kovalchuk M. S. 
Published: February 2023

Aim. To determine the characteristics of erythrocyte parameters, iron metabolism, erythropoiesis, inflammation markers in patients with heart failure (CHF) and anemia.Material and methods. The study included 68 patients with HF to describe the characteristics of anemia (general group). Patients of the general group were divided into 3 subgroups depending on the serum ferritin (SF) and transferrin saturation (TS).Results. Anemia in HF is not always associated with iron deficiency (ID), characterized by inadequate production of erythropoietin, increased levels of C-reactive protein and hepcidin. From the general group of patients, the following were distinguished: absolute ID (43%), functional ID (19%), and non-ID anemia (38%).Conclusion. In the general group of patients with HF, anemia is normochromic, normocytic, characterized by high levels of C-reactive protein, hepcidin, and inadequate production of erythropoietin. Patients with absolute and functional ID do not differ in the main iron metabolism parameters and in general account for 62% (p=0,01). In these two subgroups, iron supplements should be prescribed at further stages.
Speciation of iron(II/III) at the iron-cement interface: a review
Authors: Wieland Erich , Miron George Dan , Ma Bin , Geng Guoqing , Lothenbach Barbara 
Published: February 2023

AbstractSteel is used as reinforcement in construction materials and it is also an important component of cement-stabilized waste materials to be disposed of in deep geological repositories for radioactive waste. Steel corrosion releases dissolved Fe(II/III) species that can form corrosion products on the steel surface or interact with cementitious materials at the iron-cement interface. The thermodynamically stable Fe species in the given conditions may diffuse further into the adjacent, porous cement matrix and react with individual cement phases. Thus, the retention of Fe(II/III) by the hydrate assemblage of cement paste is an important process affecting the diffusive transport of the aqueous species into the cementitious materials. The diffusion of aqueous Fe(II/III) species from the steel surface into the adjacent cementitious material coupled with the kinetically controlled formation of iron corrosion products, such as by Fe(II) oxidation, decisively determines the extension of the corrosion front. This review summarises the state-of-the art knowledge on the interaction of ferrous and ferric iron with cement phases based on a literature survey and provides new insights and proper perspectives for future study on interaction systems of iron and cement.
Biofertilizer and Inorganic Fertilizers Effect on Favorable Characters for Productivity of Chickpea in Bundelkhand of Madhya Pradesh
Authors: Singh R.K. , Singh S.R.K. , Tripathi Uttam , Shrivastava Varsha , Kantwa C.R. , Kumar Sushil 
Published: February 2023

Background: A field experiment was conducted at the Instructional Farm of Krishi Vigyan Kendra, Chhatarpur during two consecutive rabi seasons of 2017-18 and 2018-19 to evaluate the effect of biofertilizers with 75% recommended dose of fertilizers on growth, yield, nutrient uptake, nutrient use efficiency and B:C ratio of chickpea (Cicer arietinum L.). Methods: In the two consecutive rabi seasons of 2017-18 and 2018-19, the experiment was laid out in randomized block design with improved wilt resistant variety of chickpea (JAKI 9218). Experiment consisted of five treatments including T0 (control), T1 (recommended dose of N:P2O5:K2O as 20:60:20 kg ha-1), T2 (recommended dose of NPK + seed inoculation by Rhizobium @ 10 g kg-1 seed), T3 (recommended dose of NPK + seed inoculation by Rhizobium and PSB separately @ 10 g kg-1 seed) and T4 (75% of recommended NPK + seed inoculation by Rhizobium @ 10 g kg-1 seed + soil application of PSB and KSB each @ 5 kg ha-1). Result: The result showed that among the biofertilizers seed treatment with Rhizobium leguminosorum @ 10 g kg-1 seed and soil application of PSB and KSB @ 5 as above along with application of 75% recommended dose of fertilizers have been significantly enhanced root nodule formation, fertilizer use efficiency, productivity and reduced wilt infestation under this treatment followed by recommended dose of NPK + seed inoculation by Rhizobium and PSB separately @ 10 g kg-1 seed as compared to control plot.
Use of the International Classification of Functioning, Disabilities and Health in assessing the readiness of persons with disabilities to be accompanied when receiving services, including accompanied accommodation
Authors: Sokurov A. V. , Ermolenko T. V. , Kozhushko L. A. , Ishutinа I. S. , Рavlova S. V. , Ryabtsev M. V. 
Published: February 2023

Introduction. Currently, assisted living technologies are actively developing in the Russian Federation. When receiving social services, education, promotion of employment, disabled people need to be accompanied. The effectiveness of these measures depends both on the conditions for the provision of services, the qualifications of accompanying persons, determining the required amount of support, on the ability of a disabled person to live independently and work, and on the readiness of the disabled person to be accompanied when receiving services, including a joint venture.Target. Rationale for the use of the International Classification of Functioning, Disabilities and Health in assessing the degree of readiness of persons with disabilities to be accompanied when receiving services, including accompanied accommodation.Materials and methods. Analysis of the results of monitoring the development of joint venture technologies, presented by 85 constituent entities of the Russian Federation for the period 2020–2021 on a wide range of issues, including the organization of employment of people with disabilities who are on a permanent SP and employed people with disabilities, social employment of people with disabilities, training of people with disabilities who are on a permanent accompanied accommodation, organizing a accompanied accommodation in stationary social service institutions, etc., using the ICF in determining the readiness of people with disabilities to be accompanied.Results. The number of disabled people receiving services within the framework of accompanied accommodation was studied based on materials submitted from 85 subjects of the Russian Federation as of 01.10.2022. The monitoring analysis showed that in 80 subjects of the Russian Federation (94.1 %), work is underway to organize accompanied accommodation. In 2022, there is an increase in the number of disabled people receiving services within the framework of accompanied accommodation to 6649 people, of which 4245 people are on educational (training) accompanied accommodation, 2404 people are on permanent accompanied accommodation.Discussion. Using the methodology of the ICF, questionnaires were developed, as well as a methodology for assessing the readiness of persons with disabilities to be accompanied when receiving services, including accompanied accommodation, carried out using them.Conclusions. The developed criteria and methodology for their use make it possible to quantify the degree of readiness of persons with disabilities and children with disabilities to be accompanied when receiving services, including accompanied accommodation, and be used in the preparation of an individual support program.
Salair–Gornaya Shoria Junction (Northwestern Central Asian Orogenic Belt): Deep Structure and Tectonics from Magnetotelluric Data
Authors: Zhimulev F.I. , Pospeeva E.V. , Potapov V.V. , Novikov I.S. , Kotlyarov A.V. 
Published: February 2023

Abstract
—The Salair fold-thrust orogenic belt (Salair orogen, Salair) is located in the northwestern Altai–Sayan fold area within the Central Asian Orogenic Belt. The Salair orogen is an allochthon overriding the Kuznetsk Basin on a system of imbricate thrusts. The southern flank of the Salair thrust system is tectonically juxtaposed against the Gornaya Shoria terrane which differs markedly from Salair in its geological setting. The Salair and Gornaya Shoria terranes are separated by the Nenya-Chumysh Basin, a deep Mesozoic trough. The Salair orogen is composed of Cambrian–Early Ordovician island arc volcanic and sedimentary rocks, widespread garnet amphibolites and gneisses of the Angurep complex in its southern flank, and the Shalap subduction-related melange in the Alambai ophiolite suture. The southern Salair orogen and its junction with Gornaya Shoria have been imaged down to the lower crust by magnetotelluric (MT) soundings, which is an efficient tool for investigating the deep structure and tectonic history of orogenic areas. The MT surveys were performed at 25 stations on a 120 km long profile. MT data revealed an up to 70 km wide low-resistivity zone (a conductor) traceable till a depth of 20 km between the Salair and Gornaya Shoria terranes. The low-resistivity zone has a complex structure with its outer and interior boundaries dipping almost vertically. The conductor lies under several major geological structures: the Shalap melange, the Nenya-Chumysh Basin, and the NE trending Altai–Salair right-lateral strike-slip fault. The Altai–Salair fault, along which the Salair allochthon was displaced relative to Gorny Altai and Gornaya Shoria, joins the Salair system of imbricate thrusts. The Nenya-Chumysh Basin at the Salair–Gornaya Shoria junction is a deep trough having an asymmetric transversal profile with a steep western side and a shallower-dipping stepped eastern side. The southeastern flank of the basin is a wide area of thin sediments over the Paleozoic basement dipping gently in the northwestern direction. The revealed deep structure of the Nenya-Chumysh trough is consistent with its tectonic model implying an Early Cretaceous basin superposed over an early Jurassic pull-apart basin. Early Mesozoic motions on major faults is a regional-scale phenomenon known from many areas of southern West Siberia.
Semianalytical Model for Monitoring Fracture Liquid-Loading in Vertical Fractured Gas Wells
Authors: Wang Zhipeng , Ning Zhengfu , Guo Wenting 
Published: February 2023

Summary
Liquid loading seriously affects gas wells production and even causes gas wells abandonment. Many researchers still focus on correcting a critical liquid-loading flow rate to alleviate these problems. However, they still cannot reasonably be explained. Gas flow rate is higher than the critical liquid-loading flow rate, but liquid loading can still occur. Therefore, until an accurate critical fluid-loading flow rate is discovered, we should monitor the fluid-loading phenomenon to prevent it from affecting production gas wells’ performance. In this work, a fracture liquid-loading monitoring (FLLM) model is proposed and solved for the timely monitoring of fracture liquid-loading (FLL) positions and volume. The Newman product and Green function methods are used to develop and solve the FLLM model. The fracture is discretized into 2nxnz grids to describe an FLL volume and position. The numerical simulation method is used to verify the accuracy of the FLLM model. As a result, four innovative flow regimes, including fracture cavity liquid-loading flow, fracture root liquid-loading flow, transitional flow considering fracture cavity liquid-loading flow, and transitional flow considering fracture root liquid-loading flow, are identified on the pressure response curves. The pressure response of the same gas well at different times is well matched by the model in this paper, and the obtained parameters are more reasonable. The FLLM model can correct for magnified permeability, shortened half-length, and magnified wellbore storage coefficient. In conclusion, the FLLM model is established to monitor FLL, and alert engineers to remove liquid loading on time to prevent water from suddenly rushing into a wellbore and causing gas wells abandonment.
Individuals with severe psychiatric disorders display altered pattern of plasma immunometabolites
Authors: Hylén Ulrika , Särndahl Eva , Bejerot Susanne , Humble Mats B , Hyötyläinen Tuulia , Salihovic Samira , Eklund Daniel 
Published: February 2023

Abstract

IntroductionPsychiatric disorders are common and significantly impact the quality of life. Inflammatory processes are proposed to contribute to the emergence of psychiatric disorders. In addition to inflammation, disturbances in metabolic pathways have been observed in individuals with different psychiatric disorders. A suggested key player in the interaction between inflammation and metabolism is the Nod-like receptor 3 (NLRP3) inflammasome, and NLRP3 is known to react to a number of specific metabolites. However, little is known about the interplay between these immunometabolites and the NLRP3 inflammasome in mental health disorders.AimTo assess the interplay between immunometabolites and inflammasome function in a transdiagnostic cohort of individuals with severe mental disorders.MethodsMass spectrometry-based analysis of selected immunometabolites, previously known to affect inflammasome function, were performed in plasma from low-functioning individuals with severe mental disorders (n=39) and sex and aged-matched healthy controls (n=39) using a transdiagnostic approach. Mann Whitney U test was used to test differences in immunometabolites between psychiatric patients and controls. To assess the relationship between inflammasome parameters, disease severity, and the immunometabolites, Spearman’s rank-order correlation test was used. Conditional logistic regression was used to control for potential confounding variables. Principal component analysis was performed to explore immunometabolic patterns.ResultsAmong the selected immunometabolites (n=9), serine, glutamine, and lactic acid were significantly higher in the patient group compared to the controls. After adjusting for confounders, the differences remained significant for all three immunometabolites. No significant correlations were found between immunometabolites and disease severity.ConclusionPrevious research on metabolic changes in mental disorders has not been conclusive. This study shows that severely ill patients have common metabolic perturbations. The changes in serine, glutamine, and lactic acid could constitute a direct contribution to the low-grade inflammation observed in severe psychiatric disorders.
Seroma control in axillary lymphadenectomy with Glubran 2® without drain. Multicenter, prospective, randomized, clinical trial. GALA-ND Study (Glubran, Axillary Lymphadenectomy, Ambulatory, No Drain)
Authors: Gordo Sandra López , Ruiz-Edo Neus , Fernández-Planas Maria Teresa , Viscaya-Martín Sara , Serra-serra Cristina 
Published: February 2023

Abstract
Background: Seroma after breast cancer surgery is a frequent entity, therefore different products have been described in literature with the aim to reduce it. The most studied ones have been the sealants products, being tested with aspirative drains. Symptomatic seroma represents the 19% after axillary lymphadenectomy without drains. The aim of this study is to analyse the effect of a sealant in the seroma control after axillary lymphadenectomy without drains and identify the risk factors related to symptomatic seroma.
Methods:
This is a prospective, multicenter, international and randomized clinical trial. Patients undergoing conservative surgery and axillary lymphadenectomy for breast cancer will be randomized to control group (lymphadenectomy without sealant) or interventional group (lymphadenectomy with sealant Glubrand 2®). In any of the study groups drains are placed. Patients who received neoajuvant treatment are included. Measurements of the study outcomes will take place at baseline, at 7-14-30 days post-surgery and at 6-12 months. The primary outcome is symptomatic seroma. Secondary outcomes are seroma volume, morbidity, quality of life and lymphedema.
Discussion:
Several studies compare the use of sealant products in axillary lymphadenectomy but generally with drains. We would like to demonstrate that patients who underwent axillary lymphadenectomy could benefit from an axillary sealant without drains and reduce axillary discomfort while maintaining a good quality of life. Assessing the relationship between axillary volume, symptoms and related risk factors can be of great help in the control of seroma in patients who received breast cancer surgery.
Trial registration: ClinicalTrials.gov, NCT05280353. Registration date 02 August 2022
Semi-synthesis of Novel Thebaine Derivatives and their Anti-bacterial and Wound Healing Properties
Authors: Hasanpour Zahra , Salehi Peyman , Aliahmadi Atusa , Hoseinpour Mahdieh , Behboodi Hossein , Staerk Dan , Bararjanian Morteza 
Published: February 2023

Abstract

In the present study, some new 1,2,3-triazole-tethered analogues of N-northebaine were designed and synthesized. The anti-bacterial properties of novel thebaine derivatives were studied on Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Based on the results, compounds 5b, 5j and 5m showed the best activities against S. aureus (minimum inhibitory concentration (MIC) ~ 25 µM) compared to the parent compound (MIC = 321 µM). The most active anti-bacterial derivatives (i.e., 5b, 5j and 5m) and thebaine were considered as potent anti-bacterial wound healing agents. In this regard, fibroblast cell cytotoxicity and proliferation as well as anti-hemolytic activities of the mentioned compounds were studied. The cytotoxicity assay by using 3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyltetrazolium bromide (MTT) on Human dermal fibroblast cell lines (HDF) revealed that products 5j and 5m didn’t show inhibition of cell line growth after 24 hours and no further cytotoxic activity for a longer period (72 hours). Based on the investigation results on blood cell disruption for releasing of hemoglobin, compound 5j didn’t exhibit any hemolysis activity in different doses.
CD44 is a potential immunotherapeutic target and affects macrophage infiltration leading to poor prognosis
Authors: Liu Shuangqing , Liu Zehan , Shang Aichen , Xun Jing , Lv Zongjing , Zhou Siying , Liu Cui , Zhang Qi , Yang Yuming 
Published: February 2023

Abstract
Background
CD44 is the most common surface marker of CSCs (cancer stem cells) and plays a key role in the communication of CSCs with the microenvironment and the regulation of stem cell properties.
Methods
UALCAN was used to analyze the expression of CD44 in BLCA and normal tissue. Kaplan–Meier plotter and UALCAN were utilized to analyze the prognostic value of CD44 in BLCA. The TIMER database was used to explore the relationship between CD44 and tumor-infiltrating immune cells. The expression of CD44, the macrophage marker (CD68+), and the M2-type marker (CD163+) was evaluated using immunohistochemistry in 15 BLCA samples. GeneMania and Metascape were used to analyze protein-protein interaction investigations and functional enrichment analysis
Results
We found that patients with bladder cancer with high CD44 expression had worse survival than those with low CD44 expression (P < 0.05). Furthermore, CD44 expression is significantly associated with PD-L1 expression. Immune infiltration analysis showed that CD44 expression levels in BLCA were significantly correlated with immune infiltration levels of different immune cells. And the analysis showed that infiltration of macrophages means a worse prognosis for patients. Immunohistochemical (IHC) staining results further confirmed that the expression of CD44 was positively associated with the expression of CD68+ and CD163+ (P < 0.05).
Conclusion
Our results suggest that CD44 may be a potential immunotherapeutic target for bladder cancer, and macrophage infiltration in bladder cancer has prognostic value for bladder cancer patients. CD44 may be a key regulator of tumor macrophage infiltration and may be involved in M2 macrophage polarization. Our study sheds new light on prognosis and immunotherapy in bladder cancer patients by targeting macrophage infiltration and immune checkpoints.