bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Maximal Rowing-Ergometer Protocol to Predict Maximal Oxygen Uptake in Female Rowers
Authors: Mazza Oscar B. , Gam Søren , Kolind Mikkel E.I. , Kiær Christian , Donstrup Christina , Jensen Kurt 
Published: June 2023

Background: Laboratory assessment of maximal oxygen uptake () is physically and mentally draining for the athlete and requires expensive laboratory equipment. Indirect measurement of could provide a practical alternative to laboratory testing. Purpose: To examine the relationship between the maximal power output (MPO) in an individualized 7 × 2-minute incremental test (INCR-test) and and to develop a regression equation to predict from MPO in female rowers. Methods: Twenty female club and Olympic rowers (development group) performed the INCR-test on a Concept2 rowing ergometer to determine and MPO. A linear regression analysis was used to develop a prediction of from MPO. Cross-validation analysis of the prediction equation was performed using an independent sample of 10 female rowers (validation group). Results: A high correlation coefficient (r = .94) was found between MPO and . The following prediction equation was developed: (mL·min−1) = 9.58 × MPO (W) + 958. No difference was found between the mean predicted in the INCR-test (3480 mL·min−1) and the measured (3530 mL·min−1). The standard error of estimate was 162 mL·min−1, and the percentage standard error of estimate was 4.6%. The prediction model only including MPO, determined during the INCR-test, explained 89% of the variability in . Conclusion: The INCR-test is a practical and accessible alternative to laboratory testing of .
Management of a Special Warfare Trainee With Repeat Exertional Heat Stroke: A Case Study
Authors: Caraway J. Joseph , Shepard Julius , Hintz Courtney , Butler Cody R. 
Published: June 2023

Context: Exertional heat stroke (EHS) is the most deadly form the exertional heat illness with a higher incidence among active duty US military members than in the general population. Current guidelines on EHS recovery timelines and return to duty vary among the military branches. In some cases, individuals experience prolonged heat and exercise intolerance with repeat exertional heat illness events, which can complicate the recovery process. Management and rehabilitation of such individuals is unclear. Case Presentation: This manuscript addresses the case and management of a US Air Force Special Warfare trainee who experienced 2 episodes of EHS, despite early recognition, gold standard treatment, and undergoing 4 weeks of a stepwise recovery after an initial EHS. Management and Outcomes: After the second episode, a 3-step process was utilized, consisting of a prolonged and personalized recovery period, heat tolerance testing using Israeli Defense Force advanced modeling, and stepwise reacclimatization. This process allowed the trainee to successfully recover from repeat EHS and return to duty, and set a framework for future repeat EHS treatment guidelines. Conclusions: In individuals with repeat EHS, a prolonged recovery period followed by heat tolerance testing can be used to demonstrate appropriate thermotolerance and safely clear an individual to begin stepwise reacclimatization. Overall, patient care and military readiness may be improved by unified Department of Defense guidelines for return to duty after EHS.
Impact of the COVID-19 pandemic on the quality of medical products in Zimbabwe: a qualitative study based on key informant interviews with health system stakeholders
Authors: Yemeke Tatenda T , Umaru Farouk A , Ferrand Rashida A , Ozawa Sachiko 
Published: June 2023

ObjectiveTo explore the impact of the Coronavirus disease 2019 (COVID-19) pandemic on the quality of medical products in Zimbabwe, including market risks for substandard and falsified products and impacts on quality assurance activities.DesignQualitative study based on in-depth key informant interviews.SettingHealth system stakeholders across the medical product supply chain in Zimbabwe.Participants36 key informants were interviewed between April and June 2021.ResultsWe found that the COVID-19 pandemic disrupted quality assurance and regulatory activities of medical products in Zimbabwe, resulted in observations of poor-quality personal protective equipment (PPE) and other COVID-19-related products and led to increased risks to quality. Risks to quality due to COVID-19-related disruptions included increased layers of agents in the supply chain and an influx of non-traditional suppliers. COVID-19-related movement restrictions reduced access to health facilities and thus may have increased the usage of the informal market where smuggled and unregistered medical products are sold with less oversight by the regulator. Most reports of poor-quality medical products were for PPE, such as masks and infrared thermometers, used for the COVID-19 response. Besides these reports, many participants stated that the quality of essential medicines in the formal sector, not related to COVID-19, had largely been maintained during the pandemic due to the regulator’s stringent quality assurance process. Incentives for suppliers to maintain quality to retain large donor-funded contracts, and the need for local wholesalers and distributors to comply with quality-related aspects of distribution agreements with global manufacturers of brand-name medical products, mitigated threats to quality.ConclusionsThe COVID-19 pandemic presented opportunities and market risks for circulation of substandard and falsified medical products in Zimbabwe. There is a need for policymakers to invest in measures to safeguard the quality of medical products during emergencies and to build resiliency against future supply chain shocks.
Cerebral aneurysms: Germany-wide real-world outcome data of endovascular or neurosurgical treatment from 2007 to 2019
Authors: Haverkamp Christian , Kaier Klaus , Shah Mukesch , von zur Mühlen Constantin , Beck Jürgen , Urbach Horst , Meckel Stephan 
Published: June 2023

BackgroundEvidence on clinical outcome after endovascular treatment (EVT) vs neurosurgical clipping of intracranial aneurysms (IAs) is based on one randomized and one pseudo-randomized trial for ruptured aneurysms. Herein, we analyze nationwide real-world hospital outcomes after EVT vs clipping of ruptured and unruptured IAs.MethodsThis cohort study analyzed all EVT and clipping procedures for IAs in Germany between 2007 and 2019. The data basis was the billing-data of all German hospitals from the German Federal Statistical Office. EVT and clipping interventions, comorbidities, and in-hospital outcomes were identified using International Classification of Diseases (ICD) and Operation and Procedure (OPS) codes. Discharge type was used as a surrogate marker for functional independence. Poor clinical outcome at discharge was additionally defined by the dichotomous US National Inpatient Sample-Subarachnoid hemorrhage Outcome Measure score (NIH-SOM). Secondary outcomes included length of hospital stay, prolonged mechanical ventilation (>48 hour), and hospital reimbursement.ResultsWe analyzed 90 039 procedures (62.6% EVT, 35.52% clipping, 1.8% combined) for the treatment of IAs. After adjustment in-hospital mortality was equal after EVT compared with clipping, in ruptured IAs (adjusted OR (aOR) 0.98, p=0.707) and unruptured IAs (aOR 0.92, p=0.482). Functional independence was more likely after EVT for ruptured (aOR 0.81, p<0.001) and unruptured IAs (aOR 0.4, p<0.001). Poor clinical outcome was more likely after clipping for ruptured (aOR 0.67, p<0.001) and unruptured IAs (aOR 0.56, p<0.001).ConclusionsIn German clinical practice, we observed higher rates of functional independence and lower rates of poor outcomes at discharge with equal mortality for EVT.
Joint distraction using a purpose-built device for knee osteoarthritis: a prospective 2-year follow-up
Authors: Struik Thijmen , Mastbergen Simon C , Brouwer Reinoud W , Custers Roel J H , van Geenen Rutger C I , Heusdens Christiaan H W , Emans Pieter J , Huizinga Maarten R , Jansen Mylène P 
Published: June 2023

ObjectiveKnee distraction treatment for end-stage osteoarthritis successfully postpones arthroplasty for years. Studies performed thus far used general intended use, patient-personalised or custom-made devices. In this study, for the first time, a device specifically designed for knee distraction is evaluated.Design65 patients (≤65 years) with end-stage knee osteoarthritis indicated for arthroplasty received knee distraction. Before, 1-year and 2-year post-treatment, questionnaires were filled out and knee radiographs made. Adverse events and self-reported pain medication were registered.ResultsForty-nine patients completed 2-year follow-up: one patient did not complete treatment, three patients received arthroplasty in the first and four patients in the second year follow-up. Eight patients were lost to follow-up in the second year. The total Western Ontario and McMaster Universities Osteoarthritis Index score showed a clinically relevant improvement at 1 and 2 years (+26 and +24 points), as did all subscales (all p<0.001). The minimum radiographic joint space width improved over 1 (+0.5 mm; p<0.001) and 2 (+0.4 mm; p=0.015) years, as did the physical Short-Form 36 (+10 points; p<0.001). The most common adverse event was pin tract infection, experienced by 66% of patients, in 88% successfully treated with oral antibiotics. In two cases, hospitalisation and/or intravenous antibiotics were needed. Eight patients experienced device-related complications. None of the complications influenced 2-year outcomes. Before treatment, 42% of patients used pain medication, which had nearly been halved 1 (23%; p=0.02) and 2 years (29%; p=0.27) post-treatment.ConclusionsPatients treated with a general applicable, for knee distraction purpose-built device showed, despite adverse events, significant clinical and structural improvement over 2 years.Trial registration numberNL7986.
Detecting political biases of named entities and hashtags on Twitter
Authors: Xiao Zhiping , Zhu Jeffrey , Wang Yining , Zhou Pei , Lam Wen Hong , Porter Mason A. , Sun Yizhou 
Published: June 2023

AbstractIdeological divisions in the United States have become increasingly prominent in daily communication. Accordingly, there has been much research on political polarization, including many recent efforts that take a computational perspective. By detecting political biases in a text document, one can attempt to discern and describe its polarity. Intuitively, the named entities (i.e., the nouns and the phrases that act as nouns) and hashtags in text often carry information about political views. For example, people who use the term “pro-choice” are likely to be liberal and people who use the term “pro-life” are likely to be conservative. In this paper, we seek to reveal political polarities in social-media text data and to quantify these polarities by explicitly assigning a polarity score to entities and hashtags. Although this idea is straightforward, it is difficult to perform such inference in a trustworthy quantitative way. Key challenges include the small number of known labels, the continuous spectrum of political views, and the preservation of both a polarity score and a polarity-neutral semantic meaning in an embedding vector of words. To attempt to overcome these challenges, we propose the Polarity-aware Embedding Multi-task learning (PEM) model. This model consists of (1) a self-supervised context-preservation task, (2) an attention-based tweet-level polarity-inference task, and (3) an adversarial learning task that promotes independence between an embedding’s polarity component and its semantic component. Our experimental results demonstrate that our PEM model can successfully learn polarity-aware embeddings that perform well at tweet-level and account-level classification tasks. We examine a variety of applications—including a study of spatial and temporal distributions of polarities and a comparison between tweets from Twitter and posts from Parler—and we thereby demonstrate the effectiveness of our PEM model. We also discuss important limitations of our work and encourage caution when applying the PEM model to real-world scenarios.
Dissipative generation of significant amount of photon-phonon asymmetric steering in magnomechanical interfaces
Authors: Zheng Tian-Ang , Zheng Ye , Wang Lei , Liao Chang-Geng 
Published: June 2023

AbstractA theoretical scheme is proposed to generate significant amount of photon-phonon entanglement and asymmetric steering in a cavity magnomechanical system, which is constituted by trapping a yttrium iron garnet sphere in a microwave cavity. By applying a blue-detuned microwave driving field, we obtain an effective Hamiltonian where the magnon mode acting as an engineered resevoir cools the Bogoliubov modes of microwave cavity mode and mechanical mode via a beam-splitter-like interaction. By this means, the microwave cavity mode and mechanical mode can be driven to a two-mode squeezed state in the stationary limit. Particularly, strong two-way and one-way photon-phonon asymmetric quantum steering can be obtained with even equal dissipation. It is widely divergent with the conventional proposal, where additional unbalanced losses or noises should be imposed on the two subsystems. Our finding may be significant to expand our understanding of the essential physics of asymmetric steering and extend the potential application of the cavity spintronics to device-independent quantum key distribution.
Cardiovascular Measures of All-Cause Mortality in Duchenne Muscular Dystrophy
Authors: Soslow Jonathan H. , Xu Meng , Slaughter James C. , Crum Kimberly , Kaslow Jacob A. , George-Durrett Kristen , Raucci Frank J. , Wilkinson James D. , Cripe Linda H. , Hor Kan N. , Spurney Christopher F. , Markham Larry W. 
Published: June 2023

Background:
Cardiopulmonary failure is the leading cause of death in Duchenne muscular dystrophy (DMD). Research into DMD-specific cardiovascular therapies is ongoing, but there are no Food and Drug Administration-approved cardiac end points. To adequately power a therapeutic trial, appropriate end points must be chosen and the rate of change for these end points reported. The objective of this study was to evaluate rate of change for cardiac magnetic resonance and blood biomarkers and to determine which measures associate with all-cause mortality in DMD.

Methods:
Seventy-eight DMD subjects underwent 211 cardiac magnetic resonance studies analyzed for left ventricular (LV) ejection fraction, indexed LV end diastolic and systolic volumes, circumferential strain, late gadolinium enhancement presence and severity (global severity score, and full width half maximum), native T1 mapping, T2 mapping, and extracellular volume. Blood samples were analyzed for BNP (brain natriuretic peptide), NT-proBNP (N-terminal pro-B-type natriuretic peptide), and troponin I. Cox proportional hazard regression modeling was performed with all-cause mortality as the outcome.

Results:

Fifteen subjects (19%) died. LV ejection fraction, indexed end systolic volumes, global severity score, and full width half maximum worsened at 1 and 2 years while circumferential strain and indexed LV end diastolic volumes worsened at 2 years. LV ejection fraction, indexed LV end diastolic and systolic volumes, late gadolinium enhancement full width half maximum, and circumferential strain associated with all-cause mortality (
P
<0.05). NT-proBNP was the only blood biomarker that associated with all-cause mortality (
P
<0.05).

Conclusions:
LV ejection fraction, indexed LV volumes, circumferential strain, late gadolinium enhancement full width half maximum, and NT-proBNP are associated with all-cause mortality in DMD and may be the best end points for use in cardiovascular therapeutic trials. We also report change over time of cardiac magnetic resonance and blood biomarkers.
Black Queer Fugitivity: Agency, Language, and Digital Joy
Authors: Taylor Leonard D. , Harry Dion T. , Blockett Reginald A. 
Published: June 2023

Abstract
Moving beyond axial considerations, we recount the experiences of Black queer educators and the literacies we engage in for survival and thriving (Blockett et al. 2022). In our pointed exploration of virtual and physical, we consider anti-Black and anti-queer moments as sites of fugitivity – a Black resistance formation (Best & Hartman 2005; Givens 2021). For this paper, we focus on non-conventional, un-codified, rule-defying literacies that Black queer people have and continued to engage to resist, subvert, decenter, exist, and create. In doing so we provide insight into the survival and agency of Black queer people, and invite opportunities to consider new possible futures for the experiences of Black queer educators.
Queer Worldmaking in Animal Crossing: Disruptive and Joyful Critical Media Literacies
Authors: Shelton Stephanie Anne , Coogler Carlson H. , Watson Venus 
Published: June 2023

Abstract
While the educational possibilities for the Nintendo Switch video game Animal Crossing: New Horizon seem near-endless, we have been particularly struck with the game’s worldmaking potential, and the ways that such opportunities push against pervasive anti-queer and anti-trans educational legislation, while offering queer- and trans- affirming communities and creativity for players. Through analysis of online gaming communities, online gaming community, and authors’ gameplay, this paper explores the research question: How does acnh afford players opportunities to engage in queer- and trans-affirming worldmaking through critical media literacies? Our findings include considerations of the in-game gender elasticity afforded players and player-created online lgbtq+ communities.
Gluteal Muscle Size and Quality in Professional Ballet Dancers Compared to Non-Dancing Athletes
Authors: McMillan Rachael Mary , Mayes Susan , Cook Jillianne , Semciw Adam Ivan , Plass Lindsey Marie , Pizzari Tania 
Published: June 2023

Introduction: Professional ballet dancers load their hips in extreme ranges of motion and commonly report hip pain. Evaluating gluteal muscle size and quality may help guide exercise programs. Objectives of this study were to compare gluteal muscle size and quality (fatty infiltration) in ballet dancers compared to athletes; and to investigate the relationship between gluteal muscle size and quality, and reports of hip-related pain. Methods: This study was a case-control design. Professional ballet dancers (current and retired, n = 49, mean age 35 years, range 19-63) and age and sex-matched athletes (current and retired, n = 49) underwent magnetic resonance imaging of both hips. Muscle cross-sectional areas (CSA) were obtained at standardized landmarks for gluteus maximus (GMax) and gluteus medius (GMed). Full muscle volume was calculated for gluteus minimus (GMin). Fatty infiltration was rated using the Goutallier classification system. Muscle size was compared between groups using linear mixed models. Fatty infiltration was compared using a mixed model binary logistic regression. Hip-related pain, participation status, limb side and sex were included as covariates. Results: Ballet dancers had significantly larger GMax (upper P < .01, middle P < .01, lower P = .01) and GMed (level of anterior inferior iliac spine P < .01, greater sciatic foramen P < .01) CSA and larger GMin volume ( P < .01), when normalized to weight. There was no difference in fatty infiltration ratings between dancers and non-dancing athletes. Retired dancers and athletes reporting hip-related pain were more likely to have fatty infiltration in GMax lower ( P = .04). Conclusion: Gluteal muscles are larger in ballet dancers compared to athletes suggesting high-level loading of these muscles. There is no relationship between hip-related pain and gluteal muscle size. Dancers and athletes have comparable muscle quality.
Factors associated with fall risk of community-dwelling older people: A decision tree analysis
Authors: Fong Kenneth N K , Chung Raymond C K , Sze Patrick P C , NG Carmen K M 
Published: June 2023

Objective To examine the predictive attributes for accidental falls in community-dwelling older people in Hong Kong using decision tree analysis. Methods We recruited 1151 participants with an average age of 74.8 years by convenience sampling from a primary healthcare setting to carry out the cross-sectional study over 6 months. The whole dataset was divided into two sets, namely training set and test set, which respectively occupied 70% and 30% of the whole dataset. The training dataset was used first; decision tree analysis was used to identify possible stratifying variables that could help to generate separate decision models. Results The number of fallers was 230 with 20% 1-year prevalence. There were significant differences in gender, use of walking aids, presence of chronic diseases, and co-morbidities including osteoporosis, depression, and previous upper limb fractures, and performance in the Timed Up and Go test and the Functional Reach test among the baselines between the faller and non-faller groups. Three decision tree models for the dependent dichotomous variables (fallers, indoor fallers, and outdoor fallers) were generated, with overall accuracy rates of the models of 77.40%, 89.44% and 85.76%, respectively. Timed Up and Go, Functional Reach, body mass index, high blood pressure, osteoporosis, and number of drugs taken were identified as stratifying variables in the decision tree models for fall screening. Conclusion The use of decision tree analysis for clinical algorithms for accidental falls in community-dwelling older people creates patterns for decision-making in fall screening, which also paves the way for utility-based decision-making using supervised machine learning in fall risk detection.
Identification of USP9X as a leukemia susceptibility gene
Authors: Sisoudiya Saumya Dushyant , Mishra Pamela , Li He , Schraw Jeremy M. , Scheurer Michael E. , Salvi Sejal , Doddapaneni Harsha , Muzny Donna , Mitchell Danielle , Taylor Olga , Sabo Aniko , Lupo Philip J. , Plon Sharon E. 
Published: June 2023

Abstract
We recently reported that children with multiple birth defects have a significantly higher risk of childhood cancer. We performed whole-genome sequencing on a cohort of probands from this study with birth defects and cancer and their parents. Structural variant analysis identified a novel 5 kb de novo heterozygous inframe deletion overlapping the catalytic domain of USP9X in a female proband with multiple birth defects, developmental delay, and B-cell acute lymphoblastic leukemia (B-ALL). Her phenotype was consistent with female-restricted X-linked syndromic intellectual developmental disorder-99 (MRXS99F). Genotype-phenotype analysis including previously reported female probands (n = 42) demonstrated that MRXS99F probands with B-ALL (n = 3) clustered with subjects with loss-of-function (LoF) USP9X variants and multiple anomalies. The cumulative incidence of B-ALL among these female probands (7.1%) was significantly higher than an age- and sex-matched cohort (0.003%) from the Surveillance, Epidemiology, and End Results database (P &lt; .0001, log-rank test). There are no reports of LoF variants in males. Males with hypomorphic missense variants have neurodevelopmental disorders without birth defects or leukemia risk. In contrast, in sporadic B-ALL, somatic LoF USP9X mutations occur in both males and females, and expression levels are comparable in leukemia samples from both sexes (P = .54), with the highest expressors being female patients with extra copies of the X-chromosome. Overall, we describe USP9X as a novel female-specific leukemia predisposition gene associated with multiple congenital, neurodevelopmental anomalies, and B-ALL risk. In contrast, USP9X serves as a tumor suppressor in sporadic pediatric B-ALL in both sexes, with low expression associated with poorer survival in patients with high-risk B-ALL.