bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do radioiodine-avid lymph nodes from differentiated thyroid cancer on the initial posttherapy scan need repeated 131I therapy?
Authors: Jiang Yongji , Liu Simin , Qiu Xiaotong , Huo Yanlei , Zhang Xiaoying , Cai Haidong , Lv Zhongwei , Ma Chao 
Published: May 2023

BackgroundResidual/recurrent lymph node metastase (LNM) is often found after differentiated thyroid cancer (DTC) surgery. This study aimed to investigate whether patients complicated with radioiodine-avid (131I+) lymph nodes from DTC on the initial posttherapy scan (PTS) need repeated 131I therapy.MethodsFrom June 2013 to August 2022, DTC patients with 131I+ lymph nodes on the initial PTS who received at least two cycles of 131I therapy were retrospectively enrolled. They were divided into a complete response (CR) group and an incomplete response (IR) group according to their response to the initial 131I therapy based on the 2015 American Thyroid Association (ATA) guidelines.ResultsA total of 170 DTC patients with 131I+ lymph nodes on the initial PTS were included; 42/170 (24.7%) patients were classified into the CR group and 128/170 (75.9%) were classified into the IR group according to their response to the initial 131I therapy. None of the 42 CR patients had disease progression at the subsequent follow-up, and 37/170 (21.8%) IR patients improved after repeated therapy. Univariate analysis showed that N stage (P=0.002), stimulated thyroglobulin (sTg) level before initial 131I therapy (P&lt;0.001), LNM size (P&lt;0.001), number of total residual/recurrent LNM (P=0.021), radioiodine-nonavid (131I-) LNM (P=0.002) and ultrasound features (P&lt;0.001) were related to the initial treatment response. On multivariate analysis, sTg level (OR=1.186, P&lt;0.001) and LNM size (OR=1.533, P=0.004) were independent risk factors for IR after initial 131I therapy. The optimal sTg level and LNM size cutoff value for predicting the treatment response after initial 131I therapy were 18.2 µg/l and 5mm.ConclusionThis study suggested that approximately one-quarter of patients with 131I+ lymph nodes on initial PTS, especially those with N0 or N1a stage, lower sTg level, smaller LNM size, ≤2 residual/recurrent LNMs, negative ultrasound features and no 131I- LNM, remain stable after one cycle of 131I therapy and do not need repeated therapy.
Axial spondyloarthritis in patients with recurrent fever attacks: data from the AIDA network registry for undifferentiated autoInflammatory diseases (USAIDs)
Authors: Vitale Antonio , Caggiano Valeria , Silva Isabel , Oliveira Daniel G. , Ruscitti Piero , Ciccia Francesco , Vasi Ibrahim , Tufan Abdurrahman , Lopalco Giuseppe , AlMaghlouth Ibrahim A. , Sota Jurgen , Wiesik-Szewczyk Ewa , Gaggiano Carla , Giardini Henrique Ayres Mayrink , Spedicato Veronica , Ragab Gaafar , Iannone Florenzo , Balistreri Alberto , Frassi Micol , Hernández-Rodríguez José , Fabiani Claudia , Falsetti Paolo , Di Meglio Nunzia , Frediani Bruno , Mazzei Maria Antonietta , Rigante Donato , Faria Raquel , Cantarini Luca 
Published: May 2023

BeckgroundDespite the recent advances in the field of autoinflammatory diseases, most patients with recurrent fever episodes do not have any defined diagnosis. The present study aims at describing a cohort of patients suffering from apparently unexplained recurrent fever, in whom non-radiographic axial spondylarthritis (SpA) represented the unique diagnosis identified after a complete clinical and radiologic assessment.Materials and methodsPatients’ data were obtained from the international registry on Undifferentiated Systemic AutoInflammatory Diseases (USAIDs) developed by the AutoInflammatory Disease Alliance (AIDA) network.ResultsA total of 54 patients with recurrent fever episodes were also affected by non-radiographic axial SpA according to the international classification criteria. SpA was diagnosed after the start of fever episodes in all cases; the mean age at the diagnosis of axial SpA was 39.9 ± 14.8 years with a diagnostic delay of 9.3 years. The highest body temperature reached during flares was 42°C, with a mean temperature of 38.8 ± 1.1°C. The most frequent manifestations associated to fever were: arthralgia in 33 (61.1%) cases, myalgia in 24 (44.4%) cases, arthritis in 22 (40.7%) cases, headache in 15 (27.8%) cases, diarrhea in 14 (25.9%) cases, abdominal pain in 13 (24.1%) cases, and skin rash in 12 (22.1%) cases. Twenty-four (44.4%) patients have taken daily or on-demand non-steroidal anti-inflammatory drugs (NSAIDs) and 31 (57.4%) patients have been treated with daily or on demand oral glucocorticoids. Colchicine was used in 28 (51.8%) patients, while other conventional disease modifying anti-rheumatic drugs (cDMARDs) were employed in 28 (51.8%) patients. Forty (74.1%) patients underwent anti-tumor necrosis factor (TNF) agents and 11 (20.4%) were treated with interleukin (IL)-1 inhibitors. The response to TNF inhibitors on recurrent fever episodes appeared more effective than that observed with anti-IL-1 agents; colchicine and other cDMARDs were more useful when combined with biotechnological agents.ConclusionSigns and symptoms referring to axial SpA should be inquired in patients with apparently unexplained recurrent fever episodes. The specific treatment for axial SpA may lead to a remarkable improvement in the severity and/or frequency of fever episodes in patients with unexplained fevers and concomitant axial SpA.
Enhanced external counter pulsation therapy in patients with symptomatic and severe intracranial steno-occlusive disease: a randomized clinical trial protocol
Authors: Sharma Vijay K. , Gopinathan Anil , Tan Benjamin Y. Q. , Loh Poay Huan , Hung Jennifer , Tang David , Chua Christopher , Chan Amanda C. Y. , Ong Jonathan J. Y. , Chin Amanda , Jing Mingxue , Goh Yihui , Sunny Sibi , Keat Chin Howe , Ka Zhang , Pandya Shivani , Wong Lily Y. H. , Chen Jin Tao , Yeo Leonard L. L. , Chan Bernard P. L. , Teoh Hock Luen , Sinha Arvind K. 
Published: May 2023

Intracranial stenosis is prevalent among Asians and constitutes a common cause of cerebral ischemia. While the best medical therapy carries stroke recurrence rates in excess of 10% per year, trials with intracranial stenting have been associated with unacceptable peri-procedural ischemic events. Cerebral ischemic events are strongly related to the severity of intracranial stenosis, which is high in patients with severe intracranial stenosis with poor vasodilatory reserve. Enhanced External Counter Pulsation (EECP) therapy is known to improve myocardial perfusion by facilitating the development of collateral blood vessels in the heart. In this randomized clinical trial, we evaluate whether EECP therapy may be useful in patients with severe stenosis of intracranial internal carotid (ICA) or middle cerebral artery (MCA). The review of literature, methods of evaluation, status of currently used therapeutic approaches, and trial protocol have been presented.Clinical trial registrationClinicalTrials.gov, Identifier: NCT03921827.
Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease
Authors: Morgan Alasdair G. , Thrippleton Michael J. , Stringer Michael , Jin Ning , Wardlaw Joanna M. , Marshall Ian 
Published: May 2023

IntroductionWhile 2D phase-contrast MRI is often used to examine intracranial vessels in neurovascular disease contexts, the ability of 4D flow to assess many vessels at once makes it an attractive alternative. We aimed to assess the repeatability, reliability, and conformity of 2D and 4D flow across intracranial vessels.MethodsUsing correlation analyses and paired t-tests, test-retest repeatability, intra-rater reliability, and inter-method conformity for measurements of pulsatility index (PI) and mean flow were assessed in the arteries and veins of 11 healthy volunteers. Inter-method conformity was also assessed in 10 patients with small vessel disease.ResultsRepeatability for PI measurements was mostly classed as good using both 2D (median ICC = 0.765) and 4D (0.772) methods, and for mean flow was mostly moderate across both (2D: 0.711, 4D: 0.571). 4D reliability was good for PI (0.877–0.906) and moderate for mean flow (0.459–0.723). Arterial PI measurements were generally higher using the 2D method, while mean flow was mostly higher using 4D flow.DiscussionThese results imply that PI measurement using 4D flow is repeatable and reliable across intracranial arteries and veins, but care should be paid to absolute flow measurements as they are susceptible to variation depending on slice placement, resolution, and lumen segmentation practices.
Epidemiological analysis and risk prediction of scrub typhus from 2006 to 2021 in Sichuan, China
Authors: Zhang Yao , Zhang Mengyuan , Qin Yao , Zhang Lun , Kang Dianju , Wei Rongjie , Yang Changhong 
Published: May 2023

BackgroundIn the past decade, the number of reported cases of scrub typhus (ST) has increased dramatically in Sichuan Province. We aimed to overview the epidemiological characteristics of ST, identify the variables contributing to the spatial distribution, and estimate the risk areas of ST occurrence.MethodsDaily ST cases reported at the county level from 2006 to 2021 and datasets on environmental and socioeconomic variables were obtained. Joinpoint regression model was utilized to examine the incidence trends and to calculate the annual percentage change. Global spatial autocorrelation analysis was employed to explore the spatial temporal patterns. Then BRT model was employed to identify variables that make sense and predict the risk areas of ST occurrence.ResultIt has been reported that there were 6,338 ST cases in Sichuan Province from 2006 to 2021, and the incidence rates continued to rise. Most cases were distributed between June and October each year, peaking in August. During the study period, the cases showed spatial clustering at the county level, mainly in the Panxi area, and then slowly spread to the northwest and northeast. Shrubs, precipitation, farmland and maximum temperature were the primary variables that affected the spatial distribution of this disease. It was estimated that the areas including Liangshan, Panzhihua, Bazhong, and Guangyuan were most at risk of transmission. and there were approximately 32.315 million people living in the areas with potential risk of infection throughout Sichuan.ConclusionMany counties in Sichuan Province were estimated to be susceptible to ST. Our found in this data-driven study could be used to guide the implementation of targeted prevention and control measures in high-risk areas.
Taşkın Yataklarının Ekosisteme Dayalı Kalite Durumunun Değerlendirilmesi İçin Bir Yaklaşım
Authors: AZLAK Muhammet , YÜCEL IŞILDAR Aysel Gamze 
Published: May 2023

Taşkın yatakları, nehrin taşması durumunda suyun yayıldığı, sucul ortamlarla karasal alanların bir arada olduğu ve çeşitli bitki ile hayvan türlerine ev sahipliği yapan ekosistemlerdir. Bu ekosistemler sürdürülebilir çevre ve sosyo-ekonomik açıdan önemli ekosistemler olup sağladıkları hizmetler aracılığıyla insan refahına çeşitli faydalar sağlarlar. Ancak, günümüzde şehirleşme ve tarım gibi faaliyetlerden dolayı taşkın yatağı ekosistemlerinden sağlanan hizmetler olumsuz etkilenmiş ve önemli bir kısmı kaybedilmiştir. Bu durum, taşkın yataklarının ekosistem esaslı kalitesinin değerlendirmesinin ve yönetilmesinin gerekliliğini ortaya koymuştur. Başta Avrupa ülkeleri olmak üzere pek çok ülkede taşkın yataklarının ekosistem esaslı değerlendirilmesiyle ilgili çalışmalar yürütülmeye ve ekosistem hizmetlerinin korunması için kalite durumunu dikkate alan yönetim planları hazırlanmaya başlanmıştır.
Taşkın yataklarının çeşitli müdahalelerle doğal yapılarının bozulması sorunu Türkiye için de gündemdedir. Bu nedenle Türkiye’de de taşkın yataklarının kalite durumunun değerlendirilebileceği bir metot ve yürütülen bir değerlendirme çalışmasına ihtiyaç duyulmaktadır. Bu çalışma ile bahsedilen ihtiyacı karşılamak üzere, Türkiye’deki veri altlıklarına uygun, kapsamı geniş ve Su Çerçeve Direktifi ile uyumlu değerlendirme yapan bir metot geliştirilmesi amaçlanmıştır. Bu doğrultuda ilk olarak mevcut literatürden faydalanılarak taşkın yataklarının ekosistem esaslı kalitesini değerlendirmek için kullanılan parametreler belirlenmiş ve değerlendirme kriterleri tanımlanmıştır. Daha sonra bu kriterler kullanılarak SÇD ile uyumlu bir değerlendirme yapısı oluşturulmuş ve Türkiye’de taşkın yataklarının ekosistem esaslı kalite durumlarının tespit edilmesi için kullanılabilecek bir metot geliştirilmiştir.
Role of chest computed tomography in the diagnosis of SARS-CoV-2 pneumonia in children
Authors: Korochkina E. S. , Khasanova K. A. 
Published: May 2023

Background: First PCR-confirmed COVID-19 cases among Russian children were reported in early March 2020. Chest computed tomography (CT) is the most sensitive imaging modality in diagnosing early signs of viral lung damage. Limited data are available on clinical and laboratory features of COVID-19 in children and on their correlation with imaging findings. Studying COVID-19 features in children is crucial for modern medicine, which makes our research relevant.Objective: To determine the diagnostic efficacy and correlation between laboratory, clinical, and CT findings in children and adolescents with COVID-19.Materials and methods: From February 2020 to February 2021 372 patients with suspected COVID-19 were admitted to Morozov Children’s City Clinical Hospital (Moscow, Russian Federation). This retrospective study included 158 patients who presented with positive oropharyngeal and nasopharyngeal swab results, IgM and IgG test results, changes in complete blood count, blood biochemistry and coagulation test results, clinical symptoms, and suspected SARS-CoV-2 pneumonia based on chest CT findings.Results: Chest CT sensitivity and specificity for diagnosis of SARS-CoV-2 pneumonia were up to 98% and 85%, respectively. We considered that severe respiratory motion artifacts in young children under general anesthesia adversely affected the diagnostic efficacy. Sensitivity and specificity in this group were up to 89% and 71%, respectively.Conclusions: Viral pneumonia signs on chest CT scans were statistically significantly more frequent in children with cough, respiratory failure signs, lymphopenia, and increased D-dimer and C-reactive protein levels. One of these signs or a combination of them are an indication for chest CT in children with suspected SARS-CoV-2 pneumonia.
Features of the brainstem and its cavities in three-year-old children
Authors: Baybakov S. E. , Bakhareva N. S. , Yuzhakov D. V. , Yuzhakov M. V. , Belonozhkina A. S. , Kovalenko E. S. , Gordeeva E. K. , Shevchuk D. D. 
Published: May 2023

Background: Little is known about the brainstem in healthy three-year-old children; yet there is a need for further studies because children at this age are growing and developing rapidly.Objective: To study differences in the brainstem and its cavities in healthy three-year-old children, considering the sex and bilateral asymmetry.Materials and methods: We retrospectively analyzed 120 MRI scans of healthy three-year-old children (60 boys and 60 girls) to study the brainstem features. The following parameters of the brain stem structures were assessed: 1) the length of the pons (mm), 2) the height of the pons (mm), 3) the length of the medulla oblongata (mm), 4) the height of the medulla oblongata at the upper and lower borders (mm), 5) the length and height of the vermis (mm), 6) the width of the cerebellum (mm), 7) the length, width, height of the cerebellar hemispheres (mm), 8) the length and height of the third ventricle, 9) the length of the cerebral aqueduct (mm), 10) the length and height of the fourth ventricle (mm). We assessed the compliance of quantitative parameters with the normal distribution according to the Kolmogorov-Smirnov criterion. We used Microsoft Excel 2016 tables to accumulate, correct and systemize the raw data. Statistica 10.0 software (StatSoft. Inc., USA) along with the corresponding statistical method provided the digital data. The differences were considered significant at P < .05.Results: We aimed to study sex-related differences in the basic sizes of the brainstem. The length and height of the pons, the length of the third and the fourth ventricles, and the size of the cerebellar hemispheres were greater in boys. We found a bilateral asymmetry in cerebellar hemispheres (length, width, and height).Conclusions: The changes in the complex brainstem of three-year-old children are sex-dependent and consist in active transformations of its structures.
Our experience with mitral valve repair using an autologous pericardium for recurrent mitral regurgitation
Authors: Zhurko S. A. , Aminov K. M. , Gamzaev A. B. O. , Fedorov S. A. , Lashmanov D. I. 
Published: May 2023

Objective: To present outcomes of mitral valve reinterventions for recurrent degenerative mitral regurgitation.Materials and methods: From May 2017 to February 2021 3 male patients aged 43, 50, and 54 years and an 18-year-old female patient underwent mitral valve reinterventions with an autopericardial strip at Scientific Research Institute – Specialized Cardiac Surgery Clinical Hospital named after Academician B.A. Korolev. Three patients had primary mitral valve annuloplasty using a support ring and 1 patient using an autopericardial strip. In this patient group recurrent mitral regurgitation developed within 6-33 months between the primary repair and reintervention (20 ± 13.5 months on average).Results: No hospital mortality was reported. Cardiopulmonary bypass duration averaged 109.8 ± 19.7 minutes, and myocardial ischemia lasted 77.5 ± 10.1 minutes. Two patients had an adjunctive repeat radiofrequency Maze procedure, with the supraventricular rhythm restored in 1 patient. Echocardiography demonstrated that mitral regurgitation did not exceed grade 1 at discharge. Reintervention using an autopericardial strip for recurrent mitral regurgitation significantly reduces sizes of the left atrium and left ventricle. Ejection fraction did not change after the intervention. Mitral valve peak gradient in all cases did not exceed 9 mm Hg.Conclusions: The key to a successful mitral valve reintervention is a qualitative analysis of the recurrence causes and use of various techniques and materials for intervention on the mitral valvular complex. Mitral valve reinterventions, especially in young patients, are justified if certain safety conditions are met and have similar outcomes to primary interventions.
Simultaneous laparoscopic surgery for ureteropelvic junction obstruction and retrograde intrarenal surgery for nephrolithiasis
Authors: Sergeev V. V. , Medvedev V. L. , Gabriel S. A. , Zamulin G. Yu. , Churbakov V. V. , Korotchenko Ya. Yu. , Rasulov A. A. 
Published: May 2023

Objective: To determine the surgical possibilities of the one-stage laparoscopic repair in the obstructed ureteropelvic junction (UPJ) complicated with nephrolithiasis in combination with the retrograde intrarenal surgery.Case report: The patient A., a 36-year-old male complaining about dragging pains in the right lumbar region was admitted to Urology Unit No. 1 of Krasnodar Regional Clinical Hospital No. 2. The patient underwent ultrasound examination, CT, and dynamic renal scintigraphy. The findings were as follows: the enlargement of pelvicalyceal system in the right kidney (calyx up to 22 mm, pelvis up to 50 mm), 5 calyx concrements and 2 pelvic concrements 6 to 8 mm in size, obstruction at the level of the right UPJ up to 10 mm in length, III grade hydronephrosis on the right according to Lopatkin classification.Conclusions: The combination of laparoscopic surgery and retrograde intrarenal surgery with the flexible ureteroscope and holmium laser is an effective and safe method for the treatment of UPJ obstruction complicated with nephrolithiasis.
ALISIS YURIDIS PENGENAAN HONORARUM ATAS JASA-JASA NOTARIS DI KOTA MEDAN
Authors: Meutia Keumala 
Published: May 2023

As a public official, a notary does not receive a salary from the government but has the right to withdraw an honorarium from services provided based on Law Number 2 of 2014 concerning Amendments to Law Number 30 of 2004 concerning Notary Positions, and the Notary Code of Ethics. The position of a notary makes it possible to serve requests from presenters regarding work other than making authentic deeds by receiving the agreed honorarium. The data used are primary data and secondary data.
The data collection method used is library research and field research. The data collection tool used is interviews.The results of the study show that the notary's honorarium needs to be regulated because it helps determine the minimum standard of the notary's honorarium will greatly help maintain the professionalism of the notary in carrying out his profession and prevent competition between fellow notaries and there are no violations of the law. So that the creation of justice for notaries in receiving notary services rates. The application of the Notary's honorarium in Medan City in its implementation is not always in accordance with the applicable regulations, due to the Notary's reasons in determining the honorarium, namely factors from the Notary himself, competition between Notaries, the economic value of the deed, the existence of levies, requests and interests of clients, families , life experience, friends, organization, spirituality, situational factors and other factors originating from the environment of the Notary concerned, which are taken into consideration by the Notary in determining the value of the honorarium services he provides and the agreement of both parties.
Analisis Kadar Kalium Pada Makanan dan Minuman
Authors: Sakina Irene Virda , Aprida Cantika Dewi Berliana , Andini Syfa Dwi , Utami Marsah Rahmawati , Nurfadhila Lina 
Published: May 2023

Kalium adalah salah satu unsur-unsur mineral yang diperlukan tubuh dalam jumlah tertentu disamping kalsium, fosfor, besi, magnesium, sulfur, natrium dan klor. Jika kekurangan kalium dalam tubuh manusia menyebabkan abnormalitas metabolisme terutama pada usia dini, gangguan pertumbuhan seperti tulang kurang kuat, mudah bengkok dan rapuh. Dengan ini dilakukan penelitian dengan tujuan menganalisis kadar kalium pada buah, sayur dan ikan. Metode yang digunakan dalam penelitian ini adalah literature review pencarian literature acuan dengan menggunakan database yaitu google scholar, dan research gate. Dengan literatur artikel yang dipakai ke dalam penelitian merupakan literature yang terbit pada 10 tahun terakhir (2012-2022) yang berkaitan dengan Analisis kadar kalium pada makanan dan minuman.
Hasil penelitian pengujian pada kadar kalium pada makanan ataupun minuman dengan menggunakan spektrofotometri dengan menunjukan hasil yang baik dan sesuai dengan hasil yang didapatkan. Walaupun metode lain juga dapat digunakan untuk melalukan pengujian kadar kalium pada makanan dan minuman.
Kata kunci : Kalium, Makanan, Minuman
PENGARUH FAKTOR FUNDAMENTAL MAKRO DAN MIKRO PERUSAHAAN TERHADAP NILAI PERUSAHAAN (Pada Industri Pulp and Paper yang terdaftar di BEI)
Authors: Sari Retty Purnama , Romli Harsi , Marnisah Luis 
Published: May 2023

This research aims to know the impact of macro fundamental factors such as interest rate (SBI), kurs and gross domestic product; and micro fundamental factors such as return on asset (ROA), debt to equity ratio (DER) and price earning ratio (PER) on firm value in pulp and paper industry that listed in Indonesian Stock Exchange. This research used multiple regression analysis and processed with Eviews version 8. The results of study is: 1) By partial, just interest rate have negative and no significant effect on firm value, other factors such as kurs and gross domestic products, return on asset, debt to equity ratio and price earning ratio have positive and no significant effect on firm value; 2) By Simultaneous macro fundamental factor have positive and significant effect on firm value, also micro fundamental factors have positive and significant effect on firm value; 3) By Simultaneous macro and micro fundamental factors have positive and significant effect on firm value.Â Keywords: macro fundamental factor, micro fundamental factor, firm value