bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical ridge augmentation of atrophic posterior mandible with corticocancellous onlay symphysis graft versus sandwich technique: clinical and radiographic analysis
Authors: Fekry Yasser El-Sayed , Mahmoud Nermine Ramadan 
Published: March 2023

AbstractAlveolar ridge augmentation of atrophic posterior mandibular ridge represents a challenge in oral and maxillofacial surgery to restore aesthetic and function. The aim of the study was to compare the clinical and radiographic outcomes of bone formation in atrophic posterior mandibles augmented using onlay symphysis cortico-cancellous bone block with that augmented using sandwich bone augmentation technique (Inlay). Twelve patients were selected with missing mandibular posterior teeth. CBCT were done for all patients preoperatively to assess the residual bone height, ranged between 5 and 7 mm from the inferior alveolar nerve with adequate sufficient alveolar ridge width more than 4 mm. Patients required bone augmentation procedure with autologous onlay chin graft (group I) versus those used as inlay sandwich technique (group II). Clinical and radiographic analysis were done to analyses the newly formed bone and bone height. Percent of change in bone height was also calculated and revealed that group I was higher than group II, however, statistically insignificant differences between the two groups were found regarding the percentage of newly formed bone. Vertical ridge augmentation procedures using onlay chin graft took lesser time than the interpositional grafting with fixation technique, however, both techniques are promising for vertical ridge augmentation.
Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study
Authors: Oswald Ailsa J. , Symeonides Stefan N. , Wheatley Duncan , Chan Stephen , Brunt Adrian Murray , McAdam Karen , Schmid Peter , Waters Simon , Poole Christopher , Twelves Chris , Perren Timothy , Bartlett John , Piper Tammy , Chisholm Eve Macdonald , Welsh Michelle , Hill Robert , Hopcroft Lisa E. M. , Barrett-Lee Peter , Cameron David A. 
Published: March 2023

Abstract
Purpose
The development of oestrogen resistance is a major challenge in managing hormone-sensitive metastatic breast cancer. Saracatinib (AZD0530), an oral Src kinase inhibitor, prevents oestrogen resistance in animal models and reduces osteoclast activity. We aimed to evaluate the efficacy of saracatinib addition to aromatase inhibitors (AI) in patients with hormone receptor-positive metastatic breast cancer.

Methods
This phase II multicentre double-blinded randomised trial allocated post-menopausal women to AI with either saracatinib or placebo (1:1 ratio). Patients were stratified into an “AI-sensitive/naïve” group who received anastrozole and “prior-AI” group who received exemestane. Primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR) and toxicity.

Results
140 patients were randomised from 20 UK centres to saracatinib/AI (n = 69) or placebo/AI (n = 71). Saracatinib was not associated with an improved PFS (3.7 months v. 5.6 months placebo/AI) and did not reduce likelihood of bony progression. There was no benefit in OS or ORR. Effects were consistent in “AI-sensitive/naive” and “prior-AI” sub-groups. Saracatinib was well tolerated with dose reductions in 16% and the main side effects were gastrointestinal, hypophosphatemia and rash.

Conclusion
Saracatinib did not improve outcomes in post-menopausal women with metastatic breast cancer. There was no observed beneficial effect on bone metastases.
CRUKE/11/023, ISRCTN23804370.
Symptoms of Selective Mutism in Middle Childhood: Psychopathological and Temperament Correlates in Non-clinical and Clinically Referred 6- to 12-year-old Children
Authors: Muris Peter , Büttgens Leonie , Koolen Manouk , Manniën Cynthia , Scholtes Noëlle , van Dooren-Theunissen Wilma 
Published: March 2023

AbstractThe purpose of this study was to study psychopathological and temperamental correlates of selective mutism (SM) (symptoms) in a mixed sample of non-clinical (n = 127) and clinically referred (n = 42, of whom 25 displayed the selective non-speaking behavior that is prototypical for SM) 6- to 12-year-old children. Parents completed questionnaires to measure their child’s symptom levels of selective mutism, social anxiety, autism spectrum disorder, and the temperament trait of behavioral inhibition. The results first and foremost showed that SM symptoms were clearly linked to social anxiety and an anxiety-prone temperament (behavioral inhibition), but findings also suggested that autism spectrum problems are involved in the selective non-speaking behavior of children. While the latter result should be interpreted with caution given the methodological shortcomings of this study, findings align well with the notion that SM is a heterogeneous psychiatric condition and that clinical assessment and treatment need to take this diversity into account.
Is nobody interested in the future of banks? a scoping literature review on the state of the debate
Authors: Hübenbecker Ulf 
Published: March 2023

AbstractNarratives are playing an increasingly important role in economics since their performative character has been realised. Banks are not unaffected by this, as they face many future challenges and are thus directly affected by narratives. For this reason, this article aims to reveal the future prospects within the academic landscape on the basis of a scoping literature review to create transparency about where the narratives come from. So, it is not the intention to make another prediction about the future of the banks. The paper presents contributions that make explicit statements about the future of banks, either a description of the future or an assessment of the future prospects of banks. Two databases were searched in this context, IDEAS/RePEc and Scopus, for the period from 2001 to 2021. A total of 99 relevant contributions were identified and finally used to answer three questions: (1) What challenges are seen for banks in the future? (2) What kind of future is depicted? (3) How are the future prospects derived? It turns out that challenges are seen in profitability, regulation, technology, and customer behaviour. The future prospects vary considerably, which puts the focus on the last question. Among other things, an overemphasis on intermediation theory tends to generate negative future prospects. It can be seen that the importance of the assumptions for the derivation of future prospects has not yet been recognised and further research is necessary to get a more complete picture of the future of banks.
RETRACTED ARTICLE: International trade and environmental pollution in sub-Saharan Africa: do exports and imports matter?
Authors: Duodu Emmanuel , Mpuure Desmond Mbe-Nyire 
Published: March 2023

AbstractSub-Saharan Africa (SSA) and Africa in general are known as the lowest emitters of carbon dioxide (CO2) emissions. However, CO2 emissions in SSA are increasing, making it a problem of concern and calls for attention given its adverse consequences on human health and climate change. International trade is argued to have a vital role in global and SSA emissions in diverse ways, leading to doubts of whether trade is good or bad to the environment. As a result, we explore the environmental effect of international trade in 33 SSA countries from 1990 to 2020. The study further evaluates the differential effect of exports and imports on environmental pollution. The generalized method of moment estimator and Dumitrescu and Hurlin (D-H) causality test were utilized. The results revealed that the overall effect of trade reduces environmental pollution by about 0.10% and 0.79% in both the short and long run, respectively. Again, we observe that exports and imports minimize environmental pollution of about 0.07% and 0.45% (0.08% and 0.58%) in the short run (long run), respectively. Regarding D-H results, we noticed the existence of bidirectional causality between total trade and environmental pollution, whereas exports and imports have a unidirectional causality from CO2 emissions to exports and imports. We conclude based on the findings that international trade causes pollution reduction in SSA. Furthermore, we establish that exports and imports have a homogeneous impact on environmental pollution in SSA. Given the results, we call for trade initiatives that ensure improvement in environmental and energy efficiency technologies related to production and transportation of exported and imported goods and services.
Business plan competitions and nascent entrepreneurs: a systematic literature review and research agenda
Authors: Dana Léo-Paul , Crocco Edoardo , Culasso Francesca , Giacosa Elisa 
Published: March 2023

AbstractBusiness plan competitions (BPCs) are opportunities for nascent entrepreneurs to showcase their business ideas and obtain resources to fund their entrepreneurial future. They are also an important tool for policymakers and higher education institutions to stimulate entrepreneurial activity and support new entrepreneurial ventures from conceptual and financial standpoints. Academic research has kept pace with the rising interest in BPCs over the past decades, especially regarding their implications for entrepreneurial education. Literature on BPCs has grown slowly but steadily over the years, offering important insights that entrepreneurship scholars must collectively evaluate to inform theory and practice. Yet, no attempt has been made to perform a systematic review and synthesis of BPC literature. Therefore, to highlight emerging trends and draw pathways to future research, the authors adopted a systematic approach to synthesize the literature on BPCs. The authors performed a systematic literature review on 58 articles on BPCs. Several themes emerge from the BPC literature, including BPCs investigated as prime opportunities to develop entrepreneurial education, the effects of BPC participation on future entrepreneurial activity, and several attempts to frame an ideal BPC blueprint for future contests. However, several research gaps emerge, especially regarding the lack of theoretical underpinnings in the literature stream and the predominance of exploratory research. This paper provides guidance for practice by presenting a roadmap for future research on BPCs drawing from the sample reviewed. From a theoretical perspective, the study offers several prompts for further research on the topic through a concept map and a structured research agenda.
Inflammatory Cytokines Associated with Multiple Sclerosis Directly Induce Alterations of Neuronal Cytoarchitecture in Human Neurons
Authors: Meyer-Arndt Lil , Kerkering Janis , Kuehl Tess , Infante Ana Gil , Paul Friedemann , Rosiewicz Kamil Sebastian , Siffrin Volker , Alisch Marlen 
Published: March 2023

Abstract
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) coined by inflammation and neurodegeneration. The actual cause of the neurodegenerative component of the disease is however unclear. We investigated here the direct and differential effects of inflammatory mediators on human neurons. We used embryonic stem cell-derived (H9) human neuronal stem cells (hNSC) to generate neuronal cultures. Neurons were subsequently treated with tumour necrosis factor alpha (TNFα), interferon gamma (IFNγ), granulocyte–macrophage colony-stimulating factor (GM-CSF), interleukin 17A (IL-17A) and interleukin 10 (IL-10) separately or in combination. Immunofluorescence staining and quantitative polymerase chain reaction (qPCR) were used to assess cytokine receptor expression, cell integrity and transcriptomic changes upon treatment. H9-hNSC-derived neurons expressed cytokine receptors for IFNγ, TNFα, IL-10 and IL-17A. Neuronal exposure to these cytokines resulted in differential effects on neurite integrity parameters with a clear decrease for TNFα- and GM-CSF-treated neurons. The combinatorial treatment with IL-17A/IFNγ or IL-17A/TNFα induced a more pronounced effect on neurite integrity. Furthermore, combinatorial treatments with two cytokines induced several key signalling pathways, i.e. NFκB-, hedgehog and oxidative stress signalling, stronger than any of the cytokines alone. This work supports the idea of immune-neuronal crosstalk and the need to focus on the potential role of inflammatory cytokines on neuronal cytoarchitecture and function.
Graphical Abstract
The Arc Rotational Characteristics Inside a Plasma Torch with an External Magnetic Field
Authors: Perambadur Jyothikrishna , Shukla Pradeep , Klimenko Alexander Y. , Ramachandran K. , Rudolph Victor 
Published: March 2023

AbstractThis work investigates the dynamic behavior of an arc column in a DC thermal plasma torch using a three-dimensional transient model. The model assumes an axial magnetic field of constant magnitude inside the plasma torch domain which mimics a magnetic field that is generated either by a solenoid or a permanent magnet encircling the anode. Under the influence of a strong external magnetic field, the plasma arc swirls inside the torch with one end of the arc sweeping the inner surface of the anode while the other end pivoted at the cathode tip. The dynamic variation of the electric arc and its structure is analyzed by simulating a special case with a step-change in magnetic field strength. The transient simulation traces the formation of a helical arc structure as soon as the magnetic field is imposed. The arc column is seen to be axially constricted and radially diffused in the presence of a strong magnetic field. The impact of the magnetic field is also reflected in the arc attachment gap, which is the axial distance between cathode and anode attachments. The influence of magnetic field strength, arc current and gas flow rate on arc rotational frequency, voltage drop, and temperature distribution are analyzed.
Characteristics of COVID-19 vaccinated and unvaccinated patients admitted to Careggi University Hospital, Florence, Italy
Authors: Paggi Riccardo , Barbiero Anna , Manciulli Tommaso , Miftode Andreea , Tilli Marta , Lagi Filippo , Mencarini Jessica , Borchi Beatrice , Pozzi Marco , Bartalesi Filippo , Spinicci Michele , Martini Lorenzo , Coppola Alessandra , Nozzoli Carlo , Peris Adriano , Bonizzoli Manuela , Pieralli Filippo , Bartoloni Alessandro , Zammarchi Lorenzo 
Published: March 2023

AbstractMore than 11.5 billion COVID-19 vaccine doses have been administered around the world. Although vaccine effectiveness for severe infections is reported to be 89.0%, breakthrough infections are common and may lead to severe outcome in fragile population. We conducted a real-world observational study on 420 COVID-19 admitted patients from July 2021 to January 2022 in a tertiary level Italian hospital. We collected patient’s vaccination and SARS-CoV-2 serological status, SARS-CoV-2 treatments, oxygen supports, intensive (ICU) and subintensive (sub-ICU) care unit admissions, length of staying (LoS) and in-hospital mortality. One-hundred-seventy-two vaccinated and 248 unvaccinated patients were admitted during the study period. Vaccinated group (Vg) had a significantly more elevated Charlson Comorbidity Index than Unvaccinated group (UVg), and no statistical differences were found in terms of in-hospital mortality, LoS or ICU and sub-ICU admissions. Among Vg, anti-S antibodies were detected in 86.18% of patients (seropositives). Vaccinated seronegative patients’ in-hospital mortality was significantly higher than vaccinated seropositive patients (33.33% vs 10.69%, p = 0.0055): in particular, mortality rate in 45–69 years old population was higher in vaccinated seronegative group, and comparable in patients ≥ 70 years old. No differences in terms of outcome were registered between Vg and UVg, taking into account that Vg was considerably older and with more comorbidities. In line with other recent observations, higher mortality rate was evidenced for seronegative vaccinated patients. Primary prophylaxis and early treatments result to be necessary, especially for older and immunosuppressed populations.
Hispanic/Latinos and non-Hispanic whites’ childhood cancer survivors and parents: a dyadic analysis of coping resources and mental health
Authors: Ochoa Carol Y. , Cho Junhan , Miller Kimberly A. , Baezconde-Garbanati Lourdes , Chan Randall Y. , Farias Albert J. , Milam Joel E. 
Published: March 2023

Abstract
Purpose
While limited, dyadic research demonstrates the interdependent relationship between the health and adjustment after treatment between cancer survivors and caregivers. We examined interrelationships between coping resources and mental health among childhood cancer survivors (CCS)–parent dyads.

Methods
One hundred sixty CCS-parent dyads from the Project Forward pilot study completed validated questions assessing social support, religiosity, spirituality, depressive symptoms, and perceived stress. Bidirectional associations were identified with path analysis utilizing the actor-partner interdependence model (APIM). We used a multigroup approach to test for the moderating effects by Hispanic ethnicity on these relationships.

Results
Mean age of CCS was 20 years old, 51% female, 30% diagnosed with leukemia, and mean of 7 years from diagnosis. The mean age of parents was 49 years old and 89% were mothers. For both CCS and parents, perceived social support was inversely associated with their depressive symptoms and perceived stress (e.g., actor effects). Parents’ social support was not significantly associated with CCS’s depressive symptoms and stress. However, higher perceived social support by the CCS was inversely associated with parents’ depressive symptoms (β =  − 0.202, p < 0.01) and perceived stress (β =  − 0.164, p < 0.05) (e.g., partner effects). Additional actor effects were observed between spirituality, religiosity, and depressive systems when we explored the moderating effects of Hispanic ethnicity.

Conclusion
Partner effects of social support among CCS-parent dyads may influence psychological distress.

Implication for Cancer Survivors
Our findings on parent–child associations between social support and psychosocial well-being imply that survivorship care can be enhanced when the social support needs of both survivors and their parents are addressed together.
“I want it all”: exploring the relationship between entrepreneurs’ satisfaction with work–life balance, well-being, flow and firm growth
Authors: Drnovšek Mateja , Slavec Alenka , Aleksić Darija 
Published: March 2023

AbstractDrawing from the conservation of resources theory, we explore how two personal resources (satisfaction with work–life balance and experience of flow at work) contribute to two important outcomes in entrepreneurship: entrepreneurs’ subjective well-being and firm growth. Although previous research has emphasized the importance of personal factors for firm growth and explored a variety of factors affecting entrepreneurs’ subjective well-being, little attention has been paid to the role of satisfaction with work–life balance as a critical personal resource for entrepreneurs. With this study, we find that entrepreneurs’ satisfaction with work–life balance is positively associated with subjective well-being, which, in turn, mediates the relationship between satisfaction with work–life balance and firm growth. Our study also shows that experiencing flow at work accentuates the relationship between satisfaction with work–life balance and subjective well-being. Based on our findings, we offer implications for practicing entrepreneurs in terms of how to achieve higher levels of well-being and better firm growth. Specifically, we emphasize the benefits of achieving satisfaction with work–life balance, as this is important for an entrepreneur’s subjective well-being and has an indirect impact on firm growth. Stakeholders in entrepreneurial ecosystems should embrace subjective well-being as an important indicator of firm outcomes alongside traditional economic measures.
Pathophysiological Mechanisms Involved in Overactive Bladder/Detrusor Overactivity
Authors: Chess-Williams Russ , Sellers Donna J 
Published: March 2023

Abstract
Purpose of Review
To examine the latest published findings on the pathophysiological mechanisms involved in the development of overactive bladder (OAB) and detrusor overactivity (DO), and to identify common pathways linked to the risk factors associated with these conditions.

Recent Findings
Evidence is accumulating, both clinical and experimental, that many of the factors linked to the development of OAB/DO, including ageing, bladder outlet obstruction, psychological stress, and obesity are associated with reduced bladder blood flow. This induces local tissue inflammation with cytokine release and enhanced oxidative stress, ultimately resulting in altered detrusor sensitivity, detrusor hypertrophy and fibrosis, together with afferent hypersensitivity. These mechanisms would explain the symptoms of urgency and frequency observed in OAB patients. Although not a characteristic of OAB, undetected low level bacterial infections of the bladder have been proposed to explain the OAB symptoms in patients resistant to standard treatments. In this condition, inflammatory responses without reductions in perfusion activate the inflammatory pathways.

Summary
Evidence is mounting that poor bladder perfusion and local inflammatory responses are central mechanisms involved in the development of OAB/DO. As our understanding of these pathophysiological mechanisms advances, new avenues for drug development will be identified and ultimately treatment may become more individualized depending on the particular pathway involved and the drugs available.
Towards a New Classification of Cardiomyopathies
Authors: Elliott Perry 
Published: March 2023

Abstract
Purpose of Review
The aim of this paper is to briefly summarise the clinical approach to disease notation for cardiomyopathies and to highlight its limitations with respect to the integration of new knowledge about aetiology.

Recent Findings
The paper uses the recently advocated concept of arrhythmogenic cardiomyopathy as an example of the limitations of current classification systems.

Summary
At present, there is no single classification system that meets the needs of all potential users, whether they are basic scientists, clinicians, patients or families. The classical cardiomyopathy subtypes still have utility, but future disease notation needs to be modified to take into account the new and more complete phenotypes and aetiologies.