bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of sweet potato germplasm for selection of day-neutral genotypes for wider adaptability
Authors: Anil Shirly Raichal , N Sheela M. , C Mohan , N Jyothi A. , Chandra Visalakshi , Shanawas S , Sreek J. 
Published: September 2023

Abstract
A total of 61 superior genotypes which included germplasm collections and prebreeding lines of sweet potato maintained in NAGS at ICAR-CTCRI and the popular released variety Sree Arun as control were evaluated in this study for six seasons for finding out the stable performer over the seasons. The best performers in each season were continued in the following seasons along with new genotypes for evaluation for six seasons. The observed variable was the yield (kg per plant). Data analysis was performed on yield character (kg per plant) by using SAS 9.1.3 (SAS Institute, Cary, North Carolina, USA), and means were separated by the least significant difference (LSD) at (p ≤ 0.01). The dry matter, starch, sugar, fibre and ash were estimated in the selected accessions. The genetic merit of each genotype was evaluated by best linear unbiased prediction (BLUP) using restricted maximum likelihood (REML) for variance component estimation in R. The overall mean across locations and years for tuber yield showed that 526/7 (S-1609) as the best accession, followed by S-1401. A similar ranking of varieties was observed for tuber yield using BLUPs. Amongst the tested samples, two (526/7 and S-1401) were found to be superior as compared to the rest of samples in terms of sensory evaluation criteria especially consistency, texture and sweetness and overall taste.
Assessment of two brands of fentanyl test strips with 251 synthetic opioids reveals “blind spots” in detection capabilities
Authors: Hayes Kathleen L. , Lieberman Marya 
Published: September 2023

Abstract
Background
Fentanyl test strips (FTS) are a commonly deployed tool in drug checking, used to test for the presence of fentanyl in street drug samples prior to consumption. Previous reports indicate that in addition to fentanyl, FTS can also detect potent fentanyl analogs like acetyl fentanyl and butyryl fentanyl, with conflicting reports on their ability to detect prominent fentanyl analogs like carfentanil and furanyl fentanyl. Yet with hundreds of known fentanyl analogs, there has been no large-scale study rationalizing FTS reactivity to different fentanyl analogs.
Methods
In this study, 251 synthetic opioids- including 214 fentanyl analogs- were screened on two brands of fentanyl test strips to 1) assess the differences in the ability of two brands of fentanyl test strips to detect fentanyl-related compounds and 2) determine which moieties in fentanyl analog chemical structures are most crucial for FTS detection. Two FTS brands were assessed in this study: BTNX Rapid Response and WHPM DanceSafe.
Results
Of 251 screened compounds assessed, 121 compounds were detectable at or below 20,000 ng/mL by both BTNX and DanceSafe FTS, 50 were not detectable by either brand, and 80 were detectable by one brand but not the other (n = 52 BTNX, n = 28 DanceSafe). A structural analysis of fentanyl analogs screened revealed that in general bulky modifications to the phenethyl moiety inhibit detection by BTNX FTS while bulky modifications to the carbonyl moiety inhibit detection by DanceSafe FTS; we hypothesize that the different “blind spots” may be caused by different haptens used to elicit the antibodies for these different strips.
Conclusions
By utilizing both brands of FTS in routine drug checking, users could increase the chances of detecting fentanyl analogs in the “blind spot” of one brand.
Diffuse Myocardial Fibrosis is Uncommon in People with Perinatally Acquired Human Immunodeficiency Virus Infection
Authors: Williams Jason L. , MS Frances Hung , Jenista Elizabeth , Barker Piers , Chakraborty Hrishikesh , Kim Raymond , McCrary Andrew Walker , Shah Svati H. , Thielman Nathan , Bloomfield Gerald S. 
Published: September 2023

Abstract
Background
Cardiovascular disease (CVD) remains a leading cause of death in people living with HIV. Myocardial fibrosis is well-described in HIV infection acquired in adulthood. We evaluate the burden of fibrosis by cardiac magnetic resonance in people with perinatal HIV infection.
Methods
Individuals with perinatally acquired HIV (pnHIV) diagnosed before 10 years-old and on antiretroviral treatment for ≥ 6 months were matched with uninfected controls. Patients with significant cardiometabolic co-morbidities and pregnancy were excluded. Diffuse fibrosis was assessed by cardiac magnetic resonance (CMR). with native T1 mapping for calculation of extracellular volume fraction (ECV). Viability was assessed with late gadolinium enhancement. The normality of fibrosis was assessed using the Komogrov-Smirnov test. Fibrosis between the groups was analyzed using a Mann-Whitney U test, as the data was not normally distributed. Statistical significance was defined as a p-valve < 0.05.
Results
Fourteen adults with pnHIV group and 26 controls (71% female and 86% Black race) were assessed. The average (± standard deviation) age in the study group was 29 (± 4.3) years-old. All pnHIV had been on ART for decades. Demographic data, CMR functional/volumetric data, and pre-contrast T1 mapping values were similar between groups. Diastolic function was normal in 50% of pnHIV patients and indeterminate in most of the remainder (42%). There was no statistically significant difference in ECV between groups; p = 0.24.
Conclusion
Perinatally-acquired HIV was not associated with diffuse myocardial fibrosis. Early exposure to ART may be cardioprotective against development of myocardial fibrosis in patients with perinatal HIV.
Effects of Thermal Cycling on Residual Stress in Parts via Selective Laser Melting
Authors: Fang Ze-Chen , Wu Zhi-Lin , Zhao Lei , Huang Chen-Guang , Wu Chen-Wu 
Published: September 2023

Abstract
Contradictions have arisen in interpreting the parameter dependences of the residual stress in the parts formed via selective laser melting (SLM), which is thought to be clarified in the present article. Parametrical experiments were designed and conducted firstly to concentrate on the dominant significance of the typical thermal cycling in SLM. An integral definition of volumetric energy density was proposed to consider the laser beam profile and spot size. It has been proved both by the XRD and EBSD experiments that the correlation between residual stress and energy density depends on the peculiar characteristic of thermal cycling.
An experimental and computational approach to evaluate the antidiabetic activity of Guggul gum by inhibition of a common diabetes target
Authors: Jain Shalini , Sharma Mukesh Kumar , Gupta Nidhi , Chatterjee Sreemoyee 
Published: September 2023

Abstract
Background
In recent years, plant formulations with antidiabetic and antioxidant properties have gained popularity due to their lower cost and lesser side effects. Guggul gum is one such formulation that is already being used in curing arthritis, lowering cholesterol, and in weight management. The present study explored the antioxidant and antidiabetic properties of the aqua-ethanolic guggul gum extract (Commiphora wightii) using in vitro assays and in silico techniques. To predict the inhibition, GCMS-identified compounds were docked to the Human pancreatic α-amylase (PDB ID: 1HNY) in in silico studies. The inhibition of alpha-amylase enzyme (a common diabetes target) has been further evaluated at an in vitro level to show a hypoglycemic role of the compounds.
Results
The extract showed a good amount of phenolic (5.14 ± 0.011 mg) and flavonoid (0.66 ± 0.023 mg) content along with a promising free radical scavenging activity of 41.96 ± 4.02% at the highest concentration (9.6 mg/ml). For the in silico studies, the drug-likeliness of the GCMS-identified bioactive compounds of the extract was evaluated using SwissADME. Out of 6 compounds, 3 showed permissible values for LIPO, FLEX, INSATU, INSOLU, POLAR, and SIZE suggesting them as a potential candidate for antidiabetic drugs. In molecular docking studies, out of 6 GCMS-identified compounds, three showed binding energy (BE) more than the standard drug acarbose indicating better inhibition. This was further confirmed by in vitro analysis where the pancreatic α-amylase inhibitory activity of the extract and the standard drug (acarbose) at an IC50 value of 4.17 ± 1.26 mg/ml and 3.69 ± 0.89 mg/ml respectively, were comparable.
Conclusion
The results demonstrated Guggul gum as a potential alternative to commercial antidiabetic drugs. However, the isolation of the identified compounds could be done in the future for in vivo studies that can substantiate the extract’s significant role in diabetes management.
Two native andrenid bee pollinators face severe population declines in the semi-arid environments of Northwest India
Authors: Sihag Ram Chander 
Published: September 2023

Pollinator declines at the global level are the major concern of ecologists. Two ground nesting native andrenid bee species are important part of the pollination services of Northwest India. These include, Andrena savignyi Spinola an important wild pollinator of some major oilseed crops of the family Brassicaseae, and Andrena leaena Cameron an important wild pollinator of some spices crops of the family Umbelliferae, and vegetable crops of the families Brassicaceae, Apiaceae and Leguminoseae. Their importance in the agroecosystems of Northwest India notwithstanding, the actual status of their populations in such habitats is not known. The purpose of this study is to explore the latter aspect of these bees in Northwest India. A survey was conducted on the abundances of two andrenid species foraging on their respective host plants from 1990 to 2015 at an interval of 5 years. I counted the number of foraging bees of the two species on two crops viz. Andrena savignyi on a winter-flowering crop, raya (Brassica juncea) and Andrena leaena on a summer-flowering crop, carrot (Daucus carota). In 25 years, the foraging populations of Andrena savignyi declined from 4.16±0.168 bees/m2 in 1990 to 1.2±0.09 bees/m2 in 2015 and of Andrena leaena from 5.24±0.156 bees/m2 in 1990 to 1.4±0.11 bees/m2 in 2015. This decline in the numbers of foraging bees seemed to be caused by the habitat loss and poisoning of these bees due to the excessive and indiscriminate use of weedicides in the wheat and rice crops grown in this region. Viewing the importance of these bees in the pollination of crops, it is suggested that, habitat of these bees be conserved and, if at all necessary, weedicides safe to the soil nesting bees be used
Pemanfaatan Kombinasi Sistem Slow Sand Filter dan Constructed Wetland dengan Menggunakan Melati Air (Echinodorus palaefolius) dalam Pengolahan Limbah Cair di Bank Sampah Toli- Toli Mandiri
Authors: Runtulalo Junior , Sutanto Haryati Bawole , Prihatmo Guruh 
Published: September 2023

Keberadaan Bank Sampah Toli-Toli Mandiri (BSTM) telah menjadi fasilitas pengolahan sampah bagi masyarakat Toli-Toli dan sekitarnya. Proses pengolahan sampah di tempat ini meliputi pengumpulan, pemilahan dan konversi sampah. Lokasi BSTM berdekatan dengan sungai Kalangkangan yang menerima luaran langsung berwujud limbah cair dari BSTM. Pengolahan limbah cair berupa lindi potensial dilakukan menggunakan sistem filtrasi dan sistem constructed wetland yang dapat membantu menurunkan kontaminan berupa padatan tersuspensi dan patogen, serta menurunkan ragam kadar parameter kimia limbah cair. Penelitian ini bertujuan untuk mempelajari tingkat efektivitas dari kombinasi sistem slow sand filter dan constructed wetland sub-surface flow (CW-SSF) yang menggunakan tanaman melati air (Echinodorus palaefolius)dalam pengolahan limbah cair di Bank Sampah Toli-Toli Mandiri. Pengolahan limbah cair dimulai dengan pembuatan reaktor dengan desain yang terdiri dari sistem slow sand filter menggunakan pasir halus dan sistem constructed wetlands menggunakan Echinodorus palaefolius, tanah sawah, serta batu kerikil yang berukuran, 1 – 3 mm, 5 – 10 mm, 15 – 30 mm. Efisiensi penurunan parameter limbah cair BSTM setelah pengolahan dengan kombinasi sistem slow sand filter dan constructed wetland meliputi nilai COD 7,74%, TDS 62,56%, TSS 98,28%, dan fosfat 23,30%. Penggunaan sistem filtrasi slow sand filter dan constructed wetland dapat menghasilkan penurunan polutan limbah cair.
O direito à educação sob a ótica das políticas públicas: a arte de ensinar refletida na educação integral do PROEITI – SEEDF/Brasil
Authors: Da Silva Simone da Conceição Rodrigues , Dantas Otília Maria Alves da Nóbrega Alberto 
Published: September 2023

O artigo apresenta uma síntese de estudo de dissertação (SILVA, 2019) que visa a analisar o direito à educação expresso pelo Programa de Educação de Tempo Integral – Proeiti – das escolas públicas da SEEDF/Brasil. Metodologicamente, analisa-se os dados coletados mediante o questionário aplicado a 60 pais de estudantes de duas escolas públicas investigadas, que adotaram o Proeiti como política de educação. Igualmente, foi realizado um grupo focal com 19 professores. Os dados gerados destes instrumentos foram analisados à luz da técnica Análise do Discurso Crítica. Conclui-se que o Proeiti vem avançando na formação integral, de modo a se fixar em bases sólidas para a promoção da cidadania e da libertação para a realidade dos estudantes contemplados por este Programa, oriundo das políticas educacionais concebidas pelo Estado, na medida em que viabiliza a construção da formação do sujeito, mediante uma formação democrática, em prol de uma educação humanizadora e promotora de libertação.
A SAR Study on a Class of 6-(Trifluoromethyl)-pyridine Derivatives as RORγt Inverse Agonists
Authors: Ma Yi-Yuan , Cao Yu-Hao , Yang Li-Jin , Wu Shi-Han , Tong Zhen-Jiang , Wu Jia-Zhen , Wang Yi-Bo , Sha Jiu-Kai , Zhang Chen-Qian , Zheng Xin-Rui , Cai Jiao , Chen Zi-Jun , Wang Qing-Xin , Wang Jing-Jing , Zhao Jing-Han , Chang Liang , Ding Ning , Leng Xue-Jiao , Xu Jin-Guo , Dai Wei-Chen , Sun Shan-Liang , Yu Yan-Cheng , Wang Xiao-Long , Li Nian-Guang , Xue Xin 
Published: September 2023

Background:
The nuclear retinoic acid-related orphan receptor γt (RORγt) is an important
transcription factor in immune cells. Functionally, RORγt plays an important role in promoting the
differentiation of T helper 17 cells and regulating the expression of proinflammatory factors, such as
interleukin 17. Therefore, RORγt is considered a promising target for the treatment of the autoimmune
disorder. Currently, 21 RORγt inverse agonists with various scaffolds have entered clinical trials.

Objective:
To discover novel and potent RORγt inverse agonists, a series of novel 6-(trifluoromethyl)
pyridine derivatives were designed and synthesized.

Methods:
We designed and synthesized a series of potent RORγt inverse agonists W1~W16 based on
VTP-43742. Molecular docking, molecular dynamics (MD) simulation, and MM/GBSA were used to
study the structure-activity relationship (SAR) of the derivatives.

Results:
The biological activity evaluation indicated that the target compounds showed potent RORγt
inhibitory activity. The most active compound, W14, exhibited low nanomolar inhibitory activity (IC50
= 7.5 nM) in the luciferase reporter assay, which was superior to the clinical compound VTP-43742.
Analysis of the binding mode of W14 demonstrated that the interaction of -CF3 with Leu324, Leu396,
and His479 has an important contribution to the binding. Furthermore, W14 broke the H-bond formed
by His479 and Tyr502 via a “push-pull” mechanism.

Conclusion:
Compound W14 could be used as a potential RORγt inverse agonist for further modification.
Comparison of Sputum Evaluation Conversion of Pulmonary TB patients with DM and non-DM in High Burden Setting
Authors: Rahman Anita , Subianto Tantri , Mulyawan Kadek , Zulkarnaen Decky Aditya 
Published: September 2023

ABSTRACT
Background
Tuberculosis (TB) remains a global health problem and is one of the leading causes of death worldwide. By 2022, an estimated 10 million people will suffer from TB worldwide. Based on data from the Global Tuberculosis Report in 2022, Indonesia ranks second as a high-burden country in the world after India. An estimated 1.5 million people die from tuberculosis, becoming the 13th leading cause of death worldwide and the second most deadly infectious disease after COVID-19.
Currently, many new cases of TB are influenced by several risk factors, one of which is Diabetes Mellitus (DM). Pulmonary TB is a potential opportunistic infection for people with Diabetes Mellitus. TB patients with DM are at risk of sputum conversion failure after TB treatment, 1.69 times higher risk of treatment failure, 1.24 times higher risk of anti-TB drug resistance, 3.89 times higher risk of relapse, and 4.95 times higher risk of death during treatment compared to TB patients.
Aim of Study
To evaluate the sputum smear conversion results at the end of the second month of treatment of patients with Tuberculosis with Diabetes Mellitus (TB-DM) and Tuberculosis Non-Diabetes Mellitus (TB-NDM).
Methods
This research was analytical with a retrospective cohort design by taking secondary data from the Tuberculosis Information System (SITB). The data were recorded in SITB and registered as TB patients undergoing Anti-Tuberculosis Drug treatment and screening for Diabetes Mellitus in all districts in West Nusa Tenggara Province in 2022.
Results
Among 200 patients with TB in this study, male patients dominated 62% of TB patients. TB patients are mostly found in the age group 46-55 years with 28,5%. Generally, TB patients come from Mataram, with an 18% percentage. Most TB patients were diagnosed using GeneXpert (80,5%). The sputum conversion rate at the end intensive phase in TB-DM patients reached 95%, while in TB-NDM patients, only 85%. The comparative test showed a significant difference between the AFB Sputum Evaluation conversion results between TB patients and those without DM (p-value: 0.018, p<0.05).
Conclusion
There is a significant difference between the AFB Sputum Evaluation conversion results between TB patients and those without DM.

Keywords : Diabetes, diabetes mellitus, sputum conversion, tuberculosis, TB, DM
The Ethical, Care, and Client-Caregiver Relationship Impacts Resulting From Introduction of Digital Communication and Surveillance Technologies in the Home Setting: Qualitative Inductive Study
Authors: de Ruiter Hans-Peter , Clisbee David , Houston Rebecca , Skärsäter Ingela 
Published: September 2023

Background
Embedding communication and surveillance technology into the home health care setting has demonstrated the capacity for increased data efficiency, assumptions of convenience, and smart solutions to pressing problems such as caregiver shortages amid a rise in the aging population. The race to develop and implement these technologies within home care and public health nursing often leaves several ethical questions needing to be answered.

Objective
The aim of this study was to understand the ethical and care implications of implementing digital communication and surveillance technologies in the home setting as perceived by health caregivers practicing in the region of Halland in Sweden with clients receiving home care services.

Methods
A questionnaire was completed by 1260 home health caregivers and the written responses were evaluated by qualitative inductive content analysis. The researchers reviewed data independently and consensus was used to determine themes.

Results
This study identified three main themes that illustrate ethical issues and unintended effects as perceived by caregivers of introducing digital communication and surveillance technologies in the home: (1) digital dependence vulnerability, (2) moral distress, and (3) interruptions to caregiving. This study highlights the consequences of technology developers and health systems leaders unintentionally ignoring the perspectives of caregivers who practice the intuitive artistry of providing care to other humans.

Conclusions
Beyond the obtrusiveness of devices and impersonal data collection designed to emphasize health care system priorities, this study discovered a multifaceted shadow side of unintended consequences that arise from misalignment between system priorities and caregiver expertise, resulting in ethical issues. To develop communication and surveillance technologies that meet the needs of all stakeholders, it is important to involve caregivers who work with clients in the development process of new health care technology to improve both the quality of life of clients and the services offered by caregivers.
Guide Development for eHealth Interventions Targeting People With a Low Socioeconomic Position: Participatory Design Approach
Authors: Faber Jasper S , Al-Dhahir Isra , Kraal Jos J , Breeman Linda D , van den Berg-Emons Rita J G , Reijnders Thomas , van Dijk Sandra , Janssen Veronica R , Kraaijenhagen Roderik A , Visch Valentijn T , Chavannes Niels H , Evers Andrea W M 
Published: September 2023

Background
People with a low socioeconomic position (SEP) are less likely to benefit from eHealth interventions, exacerbating social health inequalities. Professionals developing eHealth interventions for this group face numerous challenges. A comprehensive guide to support these professionals in their work could mitigate these inequalities.

Objective
We aimed to develop a web-based guide to support professionals in the development, adaptation, evaluation, and implementation of eHealth interventions for people with a low SEP.

Methods
This study consisted of 2 phases. The first phase involved a secondary analysis of 2 previous qualitative and quantitative studies. In this phase, we synthesized insights from the previous studies to develop the guide’s content and information structure. In the second phase, we used a participatory design process. This process included iterative development and evaluation of the guide’s design with 11 professionals who had experience with both eHealth and the target group. We used test versions (prototypes) and think-aloud testing combined with semistructured interviews and a questionnaire to identify design requirements and develop and adapt the guide accordingly.

Results
The secondary analysis resulted in a framework of recommendations for developing the guide, which was categorized under 5 themes: development, reach, adherence, evaluation, and implementation. The participatory design process resulted in 16 requirements on system, content, and service aspects for the design of the guide. For the system category, the guide was required to have an open navigation strategy leading to more specific information and short pages with visual elements. Content requirements included providing comprehensible information, scientific evidence, a user perspective, information on practical applications, and a personal and informal tone of voice. Service requirements involved improving suitability for different professionals, ensuring long-term viability, and a focus on implementation. Based on these requirements, we developed the final version of “the inclusive eHealth guide.”

Conclusions
The inclusive eHealth guide provides a practical, user-centric tool for professionals aiming to develop, adapt, evaluate, and implement eHealth interventions for people with a low SEP, with the aim of reducing health disparities in this population. Future research should investigate its suitability for different end-user goals, its external validity, its applicability in specific contexts, and its real-world impact on social health inequality.