bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entrapment of Digoxin-KLH Conjugate in Alginate/Chitosan Nanoparticles:
A New Antigen Delivery System For Production of Anti-digoxin
Antibodies
Authors: Javid Nazli Kashani , Dounighi Nasser Mohammadpour , Arbabi Bidgoli Sepideh 
Published: May 2023

Background:
Nanoparticles have received more and more attention in the vaccine and drug delivery systems field due to their specific properties. In particular, alginate and chitosan have been known as the most promising nano-carries. Digoxin-specific antibodies effectively manage acute and chronic digitalis poisoning using sheep antiserum.

Objective:
The present study aimed to develop alginate/chitosan nanoparticles as a carrier of Digoxin-KLH to promote the immune response by improving the hyper-immunization of animals.

Methods:
The nanoparticles were produced by the ionic gelation method in mild conditions and the aqueous environment, which leads to the production of particles with favorable size, shape, high entrapment efficiency, and controlled release characteristics

Results:
The synthesized nanoparticles of 52 nm in diameter, 0.19 in PDI, and -33mv in zeta potential were considerably unparalleled and characterized by SEM, FTIR, and DSC. Nanoparticles resembled a spherical shell, smooth morphology, and homogeneous structure shown by SEM images. FTIR and DSC analyses confirmed conformational changes. Entrapment efficiency and loading capacity were 96% and 50%, respectively, via direct and indirect methods. The invitro conjugate release profile, release kinetics, and mechanism of conjugate release from the nanoparticles were studied under simulated physiological conditions for various incubation periods. An initial burst effect revealed the release profile, followed by a continuous and controlled release phase. The compound release mechanism from the polymer was due to Fickian diffusion.

Conclusion:
Our results indicated the prepared nanoparticles could be appropriate for the convenient delivery of the desired conjugate.
The Kinetics of Anti–SARS-CoV-2 Antibodies in Pediatric Patients and the Characterization of Post–COVID-19 Condition at 6 Months After Infection: Protocol for a Longitudinal Observational Study
Authors: Arguni Eggi , Chamida Fatia Murni , Indrawanti Ratni , Rusmawatiningtyas Desy , Dewi Yunika Puspa , Laksanawati Ida Safitri 
Published: May 2023

Background
Data regarding the kinetics of anti–SARS-CoV-2 antibodies and information about post–COVID-19 condition (colloquially known as “long COVID”) in children are scarce, especially in low-income countries. Even though cases of COVID-19 in children are less prevalent than adults, post–COVID-19 condition cases in children are high and have a burden that may impact their growth and development. There are other features of antibody kinetics in connection with SARS-CoV-2 infection that are yet unknown as of this writing, especially in children following infection. Furthermore, the long-term results, risk factors, and underlying pathophysiology are still uncertain. To better understand post–COVID-19 condition in children, it is necessary to further investigate the impact of clinically significant factors such multisystem inflammatory syndrome and disease severity among hospitalized survivors through their SARS-CoV-2 antibody response.

Objective
We aim to analyze anti–receptor-binding domain SARS-CoV-2 immunoglobulin G antibodies over time and characterize the signs and symptoms of post–COVID-19 condition in pediatric patients at the time of diagnosis and at 2 weeks and 1, 3, and 6 months following infection.

Methods
This is a longitudinal observational study in Indonesia. Pediatric patients diagnosed with COVID-19 by positive molecular assay using nasopharyngeal swab will be tested for anti–SARS-CoV-2 antibodies using the Roche Elecsys Anti-SARS-CoV-2 S assay at the time of diagnosis and at 2 weeks and 1, 3, and 6 months following infection. Antibody titer data will be reported as means and SDs. The respondents’ signs and symptoms will be observed up to 6 months after the onset of infection, including the vaccination event, reinfection, rehospitalization, and mortality. The clinical features will be reported as frequencies and percentages.

Results
Participant enrollment began in February 2022. As of September 30, 2022, a total of 58 patients were enrolled. After data collection, results are expected to be analyzed in August 2023.

Conclusions
This study will allow us to know the kinetics of anti–receptor-binding domain SARS-CoV-2 immunoglobulin G antibodies and data regarding post–COVID-19 condition up to 6 months following infection in the Indonesian pediatric population. Furthermore, this study has the potential to serve as a foundation for government decisions about vaccination programs and prevention measures.

International Registered Report Identifier (IRRID)
DERR1-10.2196/43344
La Discrimination À L’égard Des Enfants Autochtones Au Québec : Regard Sur L’application Indifférenciée De La Loi Sur La Protection De La Jeunesse
Authors: Garcia Emmanuelle 
Published: May 2023

Cet article porte sur la divergence et l’incompatibilité de certaines valeurs et principes sous-tendant la Loi sur la protection de la jeunesse au Québec lorsqu’appliquée aux enfants des Premières Nations, des Inuit et des Métis. Notamment, les représentations différentes de la famille et de l’intérêt de l’enfant, la pertinence de la continuité culturelle ainsi que la validité des théories d’attachement et du principe de permanence seront analysés à la lueur des écrits juridiques nationaux et internationaux s’appliquant à la situation de ces familles.

Mots-clés : peuples autochtones, familles, éducation des enfants, parentalité, continuité culturelle, attachement, permanence, intérêt de l’enfant autochtone, relations avec l’État, service social aux autochtones – Québec

This article examines the difference and incompatibility of some of the values and principles underlying the Quebec Youth Protection Act when applied to First Nations, Inuit and Métis children. In particular, the different representations of the family and the child's interest, the relevance of cultural continuity as well as the validity of attachment theories and the principle of permanence will be analyzed in regards to the national and international legal writings that apply to the situation of these families.
Pengaruh Minat Siswa pada Pembelajaran Biologi Terhadap Hasil Belajar Siswa SMA N 1 Beringin
Authors: Wahyuda Agus , Ananda Putri Ananda Putri , Humayroh Siti , Reni Rahayu Reni Rahayu , Azzahra Putri Ramadana Azzahra Putri Ramadana 
Published: May 2023

The aim of this study is to investigate the effect of students' interest in biology on academic performance. This study was conducted at SMA N 1 Beringjin in 2022. This type of survey is a sample survey of 90 students in the 11th MIPA class. The research tool was a Google Forms questionnaire with 30 questions, administered to students. The indicators of the survey are the pleasure, interest, interest and participation of students in biology. The data analysis was performed by calculating the survey score of each student, applying it to the presentation and interpreting it into categories of good, good, bad and poor. As a result, the students 'pleasure was 77.9%, the students' interest was 77.1%, the students 'interest was 76.1% and the students' participation was 75.9%. Following this study, it was found that students 'interest in learning had a positive effect on students' school results, and the average level of interest in biological research in Beringin Class XI SMAN 1 in 2022 was 76.75, a very good category, seemed to correspond with expected.
Key words: Interest, Biology Learning, Learning Outcome

ABSTRAK
Tujuan dari penelitian ini adalah untuk mengetahui pengaruh minat siswa pada biologi terhadap prestasi akademik. Penelitian ini dilakukan di SMA N 1 Beringjin pada tahun 2022. Jenis survei ini adalah sampel survei terhadap 90 siswa kelas XI MIPA. Alat penelitian adalah kuesioner Google Forms dengan 30 pertanyaan, diberikan kepada siswa. Indikator survei adalah kesenangan, minat, minat dan partisipasi siswa dalam biologi. Analisis data dilakukan dengan menghitung skor survei masing-masing siswa, menerapkannya pada presentasi dan menginterpretasikannya ke dalam kategori baik, baik, buruk dan buruk. Hasilnya, kesenangan siswa sebesar 77,9%, minat siswa sebesar 77,1%, minat siswa sebesar 76,1% dan partisipasi siswa sebesar 75,9%. Berdasarkan penelitian ini diketahui bahwa minat belajar siswa berpengaruh positif terhadap hasil belajar siswa, dan rata-rata tingkat minat penelitian biologi pada siswa kelas XI SMAN 1 Beringin tahun 2022 adalah 76,75 dengan kategori sangat baik, tampaknya sesuai dengan yang diharapkan.
Kata kunci: Minat, Pembelajaran Biologi, Hasil Belajar
Cardiovascular and Renal Benefits of Novel Diabetes Drugs by Baseline Cardiovascular Risk: A Systematic Review, Meta-Analysis, and Meta-Regression
Authors: Rodriguez-Valadez José M. , Tahsin Malak , E. Fleischmann Kirsten , Masharani Umesh , Yeboah Joseph , Park Meyeon , Li Lihua , Weber Ellerie , Li Yan , Berkalieva Asem , Max Wendy , Hunink Myriam , S. Ferket Bart 
Published: May 2023

<p> </p>
<p><strong>Objective</strong></p>
<p>Eligibility for glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) has been expanded to patients with diabetes at lower cardiovascular risk, but it is not clear whether expected treatment benefits differ by risk levels. We investigated whether patients with varying risks differ in cardiovascular and renal benefits from GLP-1RAs and SGLT2i using meta-analysis and meta-regression. </p>
<p><strong>Research Design and Methods</strong></p>
<p>We updated searches of recent meta-analyses using PubMed through November 7, 2022. We included reports of confirmatory randomized trials of GLP-1RA and SGLT2i in adult patients with safety or efficacy endpoint data. We extracted hazard ratio (HR) and event rate data for mortality, cardiovascular, and renal outcomes.</p>
<p><strong>Results</strong></p>
<p>We analyzed 9 GLP-1RA and 13 SGLT2i trials comprising 154,649 patients. Summary HRs were significant for cardiovascular mortality (GLP-1RA: 0.87; SGLT2i: 0.86), major adverse cardiovascular events (0.87; 0.88), heart failure (0.89; 0.70), and composite renal (0.84; 0.65) outcomes. For stroke, efficacy was significant for GLP-1RAs (0.84), but not for SGLT2i (0.92). We did not find statistically significant associations between control arm cardiovascular mortality rates and HRs. Five-year absolute risk differences ranged from -4.25% to -0.80%, with larger reductions (11.6%) for heart failure with SGLT2i in high risk (p for slope <.001). For GLP1-RAs, associations were nonsignificant.</p>
<p><strong>Conclusions</strong></p>
<p>Relative effects of novel diabetes drugs are preserved across baseline cardiovascular risk, whereas absolute benefits increase at higher risks, particularly regarding heart failure. Our findings suggest a need for baseline risk assessment tools to identify variation in absolute treatment benefits and improve decision-making. </p>
DINAMIKA RELASI KEHIDUPAN UMAT KRISTEN DENGAN MASYARAKAT SIKINJANG, SANGIR, SOLOK SELATAN (2010-2018)
Authors: Rahmah Putri Aulia , Salam Abdul 
Published: May 2023

Sumatera Barat sebagai wilayah administratif memiliki Minangkabau dalam bentuk wilayah kultural, identitas Minangkabau terbentuk dari percampuran antara adat dan Islam. Secara komposisi penduduk 100% masyarakat asli Solok Selatan Minangkabau beragama Islam. Adanya kelompok minoritas dalam keagamaan membuat penulis tertarik untuk melihat bagaimana dinamika relasi yang terjadi antara dua agama ini dalam hidup berdampingan. Penelitian ini merupakan jenis penelitian sejarah deskriptif analisis yaitu dengan menggambarkan dan menginterpretasikan suatu peristiwa yang terjadi pada suatu objek. Dalam penelitian ini digunakan metode sejarah yang terdiri dari tahap tahapan pokok yakni : Heuristik, Kritik Sumber, Interpretasi Data, dan Penulisan Sejarah ( historiografi). Berdasarkan hasil penelitian ini masyarakat kristen yang berada di Sikinjang merupakan masyarakat pendatang atau trasnmigran yang sudah ada sejak tahun 1987 di dominasi dari etnis Batak yang menganut Kristen Prostestan, dan Katholik yang berasal dari Kayu Aro, Kerinci. Meskipun demikian mereka tetap menjalani hidup toleransi bersama masyrakat pribumi yang mayoritas Islam, begitupun sebaliknya.

Kata kunci: Agama, Dinamika relasi dan Sikinjang.
Media Pembelajaran Ritatoon Muatan IPS Kelas V
Authors: I Nengah Suba  , Desak Putu Parmiti  , Ndara Tanggu Renda  
Published: May 2023

Model belajar konvensional berpengaruh kepada kegiatan belajar dan keaktifan siswa. Masalah yang belum prestasi di sekolah dasar yaitu masih rendahnya belajar IPS pada siswa. Tujuan penelitian ini yaitu mengembangkan media pembelajaran Ritatoon Muatan IPS Kelas V. Jenis penelitian yaitu pengembangan dengan model ADDIE. Subjek penelitian yaitu 2 orang ahli media, 1 ahli materi, 1 ahli desain dan 1 ahli praktisi. Subjek uji coba yaitu siswa kelas V yang berjumlah 12 siswa. Metode yang digunakan mengumpulkan data yaitu kuesioner. Instrument yang digunakan untuk mengumpulkan data yaitu lembar kuesioner. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian yaitu penilaian yang dilakukan oleh ahli materi pembelajaran yaitu 0,88 (sangat valid), ahli media 0,85 (sangat valid) dan ahli desain 0,94 (sangat valid). Hasil uji peorangan 1 (sangat valid) dan kelompok kecil yaitu 1 (sangat valid). Disimpulkan Media Ritatoon mendapatkan kualifikasi sangat baik dan layak digunakan. Media Ritatoon dapat membantu siswa belajar IPS
Elektrolit Polimer Padat dari Pencampuran PVDF-HFP dan PEO serta Modifikasi Filler Sebagai Bahan Dasar Baterai Lithium-Ion
Authors: Mushaddaq Reyhan Fikri , Akhmad Aminuddin Bama  , Ramlan  , Titik Lestariningsih  
Published: May 2023

Baterai lithium-ion sering mengalami masalah keamanan terkait dengan penggunaan elektrolit cair yang mudah terbakar. Untuk mengatasi masalah ini, elektrolit polimer padat digunakan sebagai pengganti elektrolit cair ; namun sampai saat ini pengembangannya dari segi konduktivitas ionik masih kurang maksimal. Untuk meningkatkan kualitas elektrolit polimer padat, banyak peneliti menggunakan polimer inang yang memiliki sifat dan keunggulan yang baik, salah satunya adalah PEO. Satu kelemahan elektrolit polimer padat yang berbasis PEO adalah kristalinitas tinggi yang menyebabkan konduktivitas ioniknya menjadi rendah. Kelemahan ini dapat dihilangkan dengan menggabungkan PEO dengan polimer lain yaitu PVDF-HFP. Penelitian ini bertujuan untuk menghasilkan lembaran polimer elektrolit yang berisi kombinasi PEO dan PVDF-HFP sebagai polimer, yang direndam di 2% asam sulfat sebagai filler, LiBOB sebagai garam lithium dan menganalisis sifat-sifat baik morfologi, kristalinitas dan konduktivitas ioniknya. Karakterisasi lembaran elektrolit dilakukan menggunakan SEM, XRD, dan EIS. Lembaran elektrolit polimer padat yang dihasilkan menunjukkan bahwa morfologi permukaan pada lembar elektrolit polimer padat berpori dengan porositas sebesar 43,27 %, kemudian Kristalinitas dari lembar sebesar 28,254 % dan konduktivitas ionik nya sebesar 5,626 x S/cm.
GPS-Based Rocket Payload Position Tracking System
Authors: Wiharta Dewa Made , Sastra Nyoman Putra , Putra A.A.B. Rama Windhu 
Published: May 2023

The Ministry of Research, Technology and Higher Education Indonesia routinely hosts a competition of payload tracking system placed on a rocket with a Ground Control Station (GCS), a competition known as Kompetisi Muatan Roket dan Roket Indonesia. Fixed GCS antenna causes some problems, including poor communication between payload and GCS, and position detection of the payload. This research was conducted to create a tracking system capable of moving the GCS antenna towards the payload position. In this research, we use two servos to move the antenna. This payload position tracking system works by calculating the azimuth angle of GCS coordinate and of the payload, then converting the azimuth value into the servo angle value. The calculation performs by Arduino Mega 2560 which then commands both the horizontal and vertical servos to direct the antenna towards the payload position. The experiments are performed with three main tests that are of tracking payload position based on GPS data, of antenna direction movement with servo horizontal motion direction, and of antenna direction movement with servo vertical motion direction. Testing are carried out by laying the payload on a drone and adjust the position and height of the drone manually. Experimental results show that the largest angular difference between the tracking system and the payload is 8 degrees azimuth. The mean angle difference is 4.7 degrees. This angle deviation occurs because the servo angle instruction can only be with an integer value.
Suggested Practices for Developing Intercultural Communication Competences in Early English Language Lessons Based on a Systematic Literature Review
Authors: Tsatzali Katerina , Beazidou Eleftheria 
Published: May 2023

In today’s globalised world, the development of Intercultural Communicative Competence is at the forefront of English Language Teaching, since it enhances students’ effective language learning as well as encourages them to gain a better and broader understanding not only of their own world, but also of the world around them. However, literature review on this topic is quite limited as regards early English language learning. Therefore, the aim of this systematic review is to provide insight on the teaching practices, techniques and learning activities employed by English language teachers in early English language learning so as to integrate the intercultural dimension in their lessons and develop their learners’ intercultural communicative competence. Data was collected from three databases Scopus, Eric, Elsevier and Google Scholar, based on predefined criteria. Findings indicate that various teaching methods, techniques and learning activities, popular in ELT, can be adapted to promote intercultural learning in early English language teaching. Moreover, online learning along with the use of different web tools and platforms, set a positive learning environment for successful intercultural interactions among culturally and linguistically diverse learners.
Transpunerea în dreptul intern a Directivei (UE) 2016/343 privind consolidarea anumitor aspecte ale prezumţiei de nevinovăţie şi a dreptului de a fi prezent la proces în cadrul procedurilor penale
Authors: Țuică Flavia-Ioana 
Published: May 2023

Prezenta lucrare reprezintă o analiză a aspectelor problematice privind transpunerea în dreptul intern a Directivei (UE) 2016/343 privind consolidarea anumitor aspecte ale prezumției de nevinovăție și a dreptului de a fi prezent la proces în cadrul procedurilor penale, în ceea ce privește reglementarea prezumției de nevinovăție, în esență articolele 1-7 din Directivă.
Pentru început sunt prezentate măsurile luate de statul român pentru a transpune Directiva; proiecte de lege complexe care ar fi adus schimbări majore Codului de procedură penală, dar și proiecte de lege care au fost în final adoptate. Apoi, autoarea trece la o analiză cronologică a dispozițiilor Directivei și a modului în care acestea se regăsesc în reglementarea națională, fiind evidențiate prevederi sau practici care nu oferă garanții suficiente persoanelor suspectate sau acuzate de comiterea unei infracțiuni. Studiul este completat de jurisprudența relevantă în materie a Curții de Justiție a Uniunii Europene, a Curții Europene a Drepturilor Omului, dar și a Curții Constituționale a României, care a adoptat decizii cu impact asupra sferei de incidență a prezumției de nevinovăție.
În final, se apreciază că stadiul actual al transpunerii Directivei 2016/343, ca urmare a închiderii procedurii de infringement împotriva statului român, este în linii mari complet, reglementarea națională suferind mai degrabă carențe din perspectiva aplicării efective și a interpretării adecvate.
GC, GC/MS analysis, and biological effects of Citrus aurantium amara essential oil
Authors: Vukić Milena D. , Branković Jovica , Ristić Marija S. 
Published: May 2023

Abstract

Citrus aurantium amara (sour orange) belongs to one of the largest genera of the Rutaceae family. The species of this genus are consumed worldwide as fresh or in form of beverages. They include well-known crops lemons, oranges, mandarins, grapefruits, and limes. The industrial processing of these fruits produces high amounts of waste (around 50%) which is a valuable source of essential oils. Since they are produced mainly from peel, considered waste, these essential oils have great economic value. In that regard, the aim of this study was to evaluate the chemical composition of the essential oil obtained from the peel of Citrus aurantium amara, as well as to assess the biological effects by the means of antioxidant and antibacterial activity. Results of GC and GC/MS analysis characterized this EO as a valuable source of limonene found in the amount of 90.4% of the total. Results of antioxidant activity indicate better inhibition of ABTS•+ (44.93 ±1.45%) compared to the DPPH• (11.03 ±1.08%). Moreover, the results of the antimicrobial assessment using the disc diffusion method displayed low inhibition potency of this essential oil towards G+ and G− bacteria and yeast strains.
Social and Communication Competences of Students: Future Teachers
Authors: Ninčević Marjan , Vukelić Dunja Jurić 
Published: May 2023

Abstract
Numerous studies have shown that teachers significantly shape student’s learning context. Socially and emotionally competent teachers tend to develop supportive and encouraging relationship with their students by promoting intrinsic motivation, focusing on student’s strengths and abilities, mediating through conflict situations and encouraging appropriate communication and prosocial behaviour. Teachers with good communication skills will create a more successful teaching and learning ambience for the students, and without communication, the teaching and learning process will not take place. Educators, parents and public today recognize the need for an educational agenda to improve academic performance, but also to enhance students’ social and communicational competence. The aim of the present study was to examine social and communication competence of the students of educational sciences and teacher education at the University of Zagreb Department Of Croatian Studies. As part of the most important aspects of the future educational work, the participants pointed out independence at work, the awareness that they would contribute to the future of the society and the awareness that they play a useful role in society. Participants also expressed optimism about their communication skills with students, planning and organizing teaching process and maintaining discipline, and to some less extent their competences for successful cooperation with students’ parents. Results were discussed in terms of possibilities to contribute to future teachers’ education.
Meaningful Learning and Effectiveness in Virtual Learning Spaces
Authors: Lopes Ana L. S. , Vieira Marili M. S. 
Published: May 2023

Abstract
Contemporary educational practices impose challenges and necessary changes in teaching and learning processes in which cyberspace and virtual contexts become places of learning. Affection, emotion, perception, and imagination compose the construction of meaningful adult knowledge. Such theoretical assumptions become fundamental for teaching and learning processes in virtual contexts in the online or distance modality. We adopted a qualitative analysis of the data of the postings in the forums and individual records of the students of the Course Methods of Studies for Distance Learning. The affectivity in virtual environments is a resource of great relevance to enhance the processes of teaching and learning. The study revealed that affectivity occurs to the extent that the student’s needs are met, and he can construct knowledge in a meaningful and conscious way.