bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing 3D modelling of MRI in the preoperative mapping of perianal fistula: How it could help the surgeons?
Authors: Boles Mary Salah Roman , El-Sayed Rania Farouk , Shawali Haney Ahmed Sami , Farag Ahmed , Fawzy Fawzy Salah , Awadallah Maryse Youssef 
Published: March 2023

Abstract
Background
Surgeons find treating perianal fistula difficult because insufficient drainage and failure to eradicate perianal sepsis could increase the risk of recurrence and postoperative complications. For better planning of the most suitable surgical technique, surgeons must consider the risk factors of recurrence with an accurate pre-operative assessment of perianal fistulae.
The most common imaging method for grading primary perianal fistulas, identifying their complications, and locating occult extensions is magnetic resonance imaging (MRI). However, surgeons may find it challenging to read the lengthy reports of complex tracts, particularly for complicated patients. The creation of three-dimensional (3D) models has gained traction recently as a genuinely useful diagnostic tool for pre-operative planning. The authors evaluated the value of these surgical models. Inspecting the 3D models in addition to the routine two-dimensional study caused four out of five skilled colorectal surgeons to re-evaluate how far the fistulae extended. This made promise that 3D models would be helpful, simple to understand, and quick to interpret for colorectal surgeons. The purpose of the study is to assess the value of adding 3D modelling of MRI to standard two-dimensional MRI protocol for more accurate delineation of perianal fistula and its complications aiming at better surgical outcomes.

Results
Regarding 3D models, the highest degree of accuracy was in detecting supra-levator extension (100%) by both the third radiologist and the surgeon. There was a statistically high diagnostic inter-observer agreement between both, with a p-value < 0.0001. The highest inter-observer agreement was in the supra-levator extension (50/50, 100%), and the lowest agreement was in the side branches detection (44/50, 88%).

Conclusions
Pre-operative 3D MRI modelling provided the surgeon with a pre- and intra-operative road map that improved the surgeon’s orientation and ability to see complex perianal fistulas and their consequences, especially those with supra levator extension, thus helping the surgeon achieve better surgical results and decrease the preoperative risk factors of recurrence. Surgeons should utilise it in complex and recurrent cases reducing preoperative risk factors and improving outcomes. Although this technique is expensive, its cost–benefit ratio is low relative to recurrent hospitalisation and complications.
Web-based payroll management system: design, implementation, and evaluation
Authors: Ahmed Ayah Mohammad , Mohammed Chira Nadheef , Ahmad Akeela Mustafa 
Published: March 2023

AbstractThe management of employees' salaries is an extremely complex task and time-consuming job due to having a large volume of payroll data and calculations. In many developing regions and countries including the Kurdistan Region of Iraq, the accounting processes of salary are manual. This leads to low speed in the calculation processes of deductions and allowances, easy making errors, difficulty to maintain salaries of previous months, low efficiency, and delay in generating reports. This paper represents the design, implementation, and evaluation of a web-based payroll management system (WPMS). This system can calculate the salary of every employee per month and annum efficiently and effectively. Moreover, it can keep the records of employees’ data including their pay, allowances, and deductions on monthly bases in the data mart. Additionally, the system can speedily and automatically generate employees’ payslips, accurate reports, and detailed statistics. Furthermore, WPMS provides a user-friendly environment and enables users to easily access, update, and delete data. The system was implemented by using programming languages: HTML, PHP, JavaScript, jQuery, AJAX, and MySQL. To conclude, the system was investigated for its usability by using the system usability scale tool. The results achieved an 87.8% score of usability satisfaction.
350-2500 nm supercontinuum white laser enabled by synergic high-harmonic generation and self-phase modulation
Authors: Hong Lihong , Hu Chenyang , Liu Yuanyuan , He Huijun , Liu Liqiang , Wei Zhiyi , Li Zhi-Yuan 
Published: March 2023

AbstractSupercontinuum white laser with large bandwidth and high pulse energy would offer incredible versatility and opportunities for basic science and high technology applications. Here, we report the generation of high-efficiency 2.8-octave-spanning ultraviolet-visible-infrared (UV-Vis-IR) (with 350-2500 nm 25 dB bandwidth) supercontinuum white laser from a single chirped periodically poled lithium niobate (CPPLN) nonlinear crystal via synergic high-harmonic generation (HHG) and self-phase modulation (SPM). The CPPLN exhibits multiple controllable reciprocal-lattice bands to simultaneously support the quasi-phase matching (QPM) for simultaneous broadband 2nd-10th HHG via cascaded three-wave mixing against a broadband fundamental pump laser. Due to the efficient second-order nonlinearity (2nd-NL) up-conversion and significant 3rd-NL SPM effect both in the pump and HHG laser pulses, 350-2500 nm supercontinuum white laser is eventually obtained with 17 μJ per pulse under pump of 45 μJ per pulse mid-infrared femtosecond laser corresponding to an average high conversion efficiency of 37%. Our work opens up a route towards creating UV-Vis-IR all-spectrum white lasers through engineering the synergic action of HHG and SPM effects in nonlinear crystals for applications in ultrafast spectroscopy, single-shot remote sensing, biological imaging, and so on.
Photonic-chip-based dense entanglement distribution
Authors: Ren Shang-Yu , Wang Wei-Qiang , Cheng Yu-Jie , Huang Long , Du Bing-Zheng , Zhao Wei , Guo Guang-Can , Feng Lan-Tian , Zhang Wen-Fu , Ren Xi-Feng 
Published: March 2023

AbstractThe dense quantum entanglement distribution is the basis for practical quantum communication, quantum networks and distributed quantum computation. To make entanglement distribution processes stable enough for practical and large-scale applications, it is necessary to perform them with the integrated pattern. Here, we first integrate a dense wavelength-division demultiplexing system and unbalanced Mach-Zehnder interferometers on one large-scale photonic chip and demonstrate the multi-channel wavelength multiplexing entanglement distribution among distributed photonic chips. Specifically, we use one chip as a sender to produce high-performance and wideband quantum photon pairs, which are then sent to two receiver chips through 1-km standard optical fibers. The receiver chip includes a dense wavelength-division demultiplexing system and unbalanced Mach-Zehnder interferometers and realizes multi-wavelength-channel energy-time entanglement generation and analysis. High quantum interference visibilities prove the effectiveness of the multi-chip system. Our work paves the way for practical entanglement-based quantum key distribution and quantum networks.
In vitro study to evaluate the effect of granulocyte colony stimulating factor on colorectal adenocarcinoma and on mesenchymal stem cells trans differentiation into cancer stem cells by cancer cells derived exosomes
Authors: Ahmed Azza Abusree , Monir Manar , Sabry Dina , Mostafa Abeer 
Published: March 2023

Abstract
Background
Colorectal cancer (CRC) is a common and lethal malignancies with poor prognosis. CRC cells release extracellular vesicles called exosomes to facilitate tumor progression by passing bioactive molecules such as proteins and nucleic acids between cells of the tumor and their microenvironment. Granulocyte colony stimulating factor (G-CSF) is a hematopoietic growth factor which mainly affects the lineage of neutrophil and exerts direct anti-tumor effects on various tumor types. The purpose of our study is to investigate the effect of G-CSF on CRC cells and to evaluate its capability to attenuate the potentiality of CRC cells derived exosomes to induce bone marrow-derived mesenchymal stem cells (BM-MSCs) malignant transformation into cancer stem cells (CSCs).

Results
The level of both lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT-1) (p = 0.014) & β-catenin (p = 0.01) was significantly decreased, whereas programmed cell death 4 (PDCD4) (p = 0.018) was increased in CRC exosomes pre-treated with G-CSF compared to untreated CRC exosomes. Additionally, there was a significant decrease in the cell proliferation in CRC cells pre-treated with G-CSF compared to untreated CRC cells (p = 0.008). Flow cytometric analysis of BM-MSCs showed that G-CSF could attenuate their transformation into CSCs.

Conclusion
G-CSF can be a promising therapeutic agent for CRC treatment.
Immunohistochemical expression of CD155 in invasive female breast carcinoma and its correlation with tumor infiltrating natural killer cells
Authors: Shibel Passant Essam Eldin , Abd Elmaogod Eman Ahmed 
Published: March 2023

Abstract
Background
CD155 is an immune checkpoint protein that interacts with ligands on natural killer cells to regulate the tumor associated immunity. CD155 overexpression has been detected in many human cancer types. CD155 and its pathways are promising tumor immunotherapy targets. We aimed to evaluate the immunohistochemical expression of CD155 in invasive breast carcinomas and to correlate such expression with the pathological parameters of the tumors and also with natural killer - tumor infiltrating lymphocytes (NK-TILs) density in breast carcinomas tissue as highlighted by CD56 immunostaining. This study included 78 cases of breast carcinomas. Immunohistochemistry was performed using antibodies against CD155 which was detected on the tumor cells and CD56 as a marker for stromal NK cells.

Results
CD155 expression by the tumor cells was detected in 30.8% of the cases and correlated significantly with advanced prognostic stage, Estrogen receptor (ER) and Progesterone receptor (PR) negativity, high Ki-67 index and Human epidermal receptor 2 (HER2) enriched molecular subtype. High stromal TILs CD56 expression was detected in 28.2% of the cases and correlated significantly with high histologic grade, PR negativity, HER2 neu over-expression, high Ki-67 index, high stromal TILs and more aggressive molecular subtypes; triple negative breast cancer, HER2 enriched and Luminal B-HER2 positive. Finally, statistically significant direct correlation was detected between Tumor cells CD155 expression and high TILs CD56 expression.

Conclusions
Our results support tumor cell CD155 expression and TILs CD56 expression in breast cancers that are high grade, TILs rich and hormone receptors negative, highlighting those cases as possible candidates for CD155 targeted therapy.
Fabrication, characterization, antimicrobial, toxicity and potential drug-delivery studies of PEGylated Sesamum indicum oil based nanoemulsion system
Authors: Bamisaye Abayomi , Eromosele Catherine O. , Dare Enock O. , Akinloye Oluseyi A. , Idowu Mopelola A. , Ighodaro Osasenaga M. , Manickam Sivakumar 
Published: March 2023

Abstract
Background
The actively mutating properties of disease-causing pathogens and GI intolerance associated with certain antibiotics among other challenges necessitated the adoption of colloidal system for drug delivery. Nanoemulsions (Ciprofloxacin (Cp) -loaded and non-drug loaded) were prepared by spontaneous emulsification method, characterized using Cryo-TEM, FTIR and Zetasizer. Antimicrobial activities were carried out using agar well diffusion method on Klebsiella pneumoniae and Bacillus subtilis. The in-vitro and dermal toxicological assessment were carried out using adult Wistar rats.

Results
The Cryo-TEM micrographs showed spherical morphology while zetasizer results showed polydispersity index (PDI), mean droplet size and zeta potential (ZP) of 0.553, 124.3 ± 0.29 nm and − 15.3 mV respectively for non-drug loaded sesame oil-based emulsion (SOAB). While 0.295, 244.8 ± 0.33 nm and − 5.54 mV were recorded for Cp-loaded sesame oil-based emulsion (SOAB + Cp). The effective voltage charge of the emulsions was 147.4 V. FTIR results of Cp recorded O–H adsorption value of 3429 cm−1, while SOAB and SOAB + Cp showed superimposition at 3427.76 cm−1 showing no drug-excipient interactions. No skin irritation was observed after 14 days of skin corrosion assessment. No significant difference (p > 0.05) in body weight gain of both test and control animals, the treatment did not cause any observable alterations in blood-chemistry parameters and hematological indices. Photomicrographs of liver and heart shows an uncompromised histological architecture.

Conclusion
The finding of the study shows a skin friendly, nanosized, spherical negatively charged emulsion with no cardiotoxic, hematotoxic and hepatotoxic effects on Wistar rats, and as such appears promising as a safe vehicle for drug delivery.

Graphical Abstract
Impact of capital structure on financial performance of oil and gas firms in Nigeria
Authors: Anozie Obumneme Renato , Muritala Taiwo Adewale , Ininm Victor Edet , Yisau Nurudeen Salako 
Published: March 2023

AbstractThis study examines the impact of capital structure on the financial performance of Nigerian oil and gas companies. Using an ex-post facto research methodology, the short-term debt to total asset, long-term debt to total asset, total debt to total equity, and return on asset variables were investigated as proxies for capital structure and financial performance, respectively. Based on the data's availability at the time of the inquiry, the study used an easy sampling strategy to gather secondary data. These data covers the years 2011 through 2020 and were compiled from the annual financial reports of five Nigerian oil and gas companies. Descriptive statistics and panel regression analysis were used to analyze the data. The analysis' findings shows that while long-term debt to total assets has a negative significant influence on return on assets, short-term debt to total assets and total debt to total equity had positive insignificant impacts. According to the findings, managers of oil and gas companies should reduce the amount of long-term debt they have because doing so has a negative effect on their performance. They should also exercise caution when making capital structure decisions.
Comparative application of derivative spectrophotometric and HPLC techniques for the simultaneous determination of lamivudine and tenofovir disoproxil fumarate in fixed-dose combined drugs
Authors: Vaikosen Edebi N. , Bunu Samuel J. , Oraeluno Jude N. , Friday David 
Published: March 2023

AbstractBackgroundLamivudine (LAM) and tenofovir disoproxil fumarate (TDF) are part of a fixed-dose combination (FDC) therapy recommended by WHO. Both drugs exhibit similar solubility in many solvent systems and tend to have overlapping spectra with maxima at 260 and 270 nm, respectively, in the UV spectrum—thus making their spectrophotometric assay difficult in FDCs. A third-order derivative (D3, d3A/dλ3) spectrophotometric technique was applied to simultaneously evaluate TDF and LAM in FDC drugs, with amplitudes at 240 and 262.5 nm, respectively. Pharmacopoeia-recommended chromatographic method was also applied for comparative purpose.ResultsMethod performance by the proposed D3technique showed linearity for LAM and TDF from 2–10 µg mL−1to 8–24 µg mL−1, respectively (R2 ≥ 0.998), while for HPLC method both drugs ranged from 0.25 to 5.0 µg mL−1(R2 ≥ 0.999). The intercepts and slopes of the regression equations were ≤ 1.62 × 10−4and ≤ 3.58 × 10−5, respectively, while calculated standard errors were ≤ 8.04 × 10−5. Limits of detection and quantification for both methods were ≤ 0.46 μg mL−1and ≤ 1.40 μg mL−1, respectively, for LAM, while corresponding limits for TDF were ≤ 2.61 and ≤ 7.90 μg mL−1. The percentage recovery for both drugs and methods ranged from 94.80 to 100.33%. The amount of LAM and TDF in brands I and II was ≥ 99.59 ± 1.19% and ≥ 99.39 ± 0.63%, respectively, for the proposed D3spectroscopic method, while corresponding values for the HPLC method were ≥ 99.86 ± 0.50 and ≥ 99.87 ± 0.32%. Statistically, both methods were adjudged to have no significant difference at 95% confidence level as the student’st-test values; experimental pairedt-andF-test values were found satisfactory.ConclusionThe D3spectrophotometric technique was time saving, cheap, simple and more environmental friendly and shows reliability, precision and accuracy and could be used for routine analysis of FDCs where HPLC is not available.Graphical abstract
Misinterpretation of a giant idiopathic concealed right iliac artery aneurysm as infantile pelvic tumor imaged by non-angiographic computed tomography: a case report
Authors: Tangsiwong Thipsumon , Tangsriwong Tipsuda 
Published: March 2023

Abstract

Background
Idiopathic pediatric artery aneurysm is extremely rare and sometimes behaves like a pelvic neoplasm. As it is associated with a high mortality while ruptured, the accurate diagnosis is indispensable to avoid life-threatening complications. Angiographic imaging is the gold standard for diagnosis and treatment planning of the aneurysm. Due to the considerably higher radiation sensitivity of children, single portal venous-phase scanning of the abdominopelvic computed tomography (CT) is, however, reasonably utilized for the evaluation of a clinically palpable mass; the erroneous diagnosis of such aneurysm can be feasible.

Case presentation
A giant idiopathic concealed right iliac artery aneurysm in a 47-day-old girl presented with a palpable pelvic mass regardless of unidentifiable predisposing factors. Non-angiographic abdominopelvic CT was reappraised by the radiology consultant according to discordance between the mass characteristics on initial CT report and those on second-look sonography, revealing the concealed aneurysm instead of solid neoplasm as it originated from right internal iliac artery. The patient underwent an emergency laparotomy with successful proximal ligation of right internal iliac artery despite intraoperative aneurysmal rupture.

Conclusions
Typical CT features for the infantile iliac artery aneurysms may be overlooked, especially if the angiographic phase is omitted; thus, the imaging characteristics of the aneurysms are more difficult to appreciate and can mimic a pelvic neoplasm. Therefore, the identification of the origin of the mass should be more practical to achieve the precise diagnosis.
Otago Home Exercise Program along with other physiotherapy interventions for the management of prolapsed intervertebral disc and its associated symptoms in an elderly: a case report
Authors: Chakraverty Sneha , Jagtap Tanmay , Mahapatra Charuhasini 
Published: March 2023

AbstractProlapsed intervertebral disc or herniated disc (PIVD) is a common cause of back pain between the ages of 30 and 50 years. But, in the elderly PIVD is associated with associated symptoms whose management is often ignored. We reported a case of an 85 years old male patient with existing symptoms of PIVD for the last 5 years. However, the patient has never gone for physiotherapy treatment for the past 5 years due to unawareness and ignorance of the same. Since it was a geriatric case, the patient presented with associated symptoms along with PIVD. We tried to focus on the associated symptoms of the patient as well along with PIVD like fall risk and balance. The intervention program constituted 3 weeks of physiotherapy intervention focusing on pain management, strength conditioning, and balance training followed by an Otago Home Exercise Program.
Cavitatory necrotising pneumonia with extrapulmonary multi-systemic involvement — a rare presentation of macrolide-resistant Mycoplasma pneumoniae
Authors: Mohan Namitha , Sawant Vishal Dnyaneshwar , Kondekar Alpana 
Published: March 2023

Abstract
Background
Mycoplasma pneumoniae is one of the leading causes of community-acquired pneumonia. Due to its microbiological variation, clinical presentations of mycoplasma infections are atypical and diverse. Multiple pulmonary and extrapulmonary manifestations of Mycoplasma pneumoniae have been documented. Among pulmonary, common manifestations are fever, malaise, lymphadenopathy, pneumonia, upper respiratory tract infections, sinusitis, etc. Necrotising pneumonia leading to cavitation as a manifestation is rather an uncommon presentation.

Case presentation
We are reporting a rare case of a 5-year-old female child who presented with bilateral haemorrhagic pleural effusion and necrotising pneumonia with cavitation along with extrapulmonary manifestation in the form of maculo-papular rash, Coombs-positive haemolytic anaemia and serositis. The child was started on azithromycin and symptomatic management, but she did not respond to it; she had clinical worsening and evidence of radiological necrotising pneumonia. The child was treated as macrolide-resistant mycoplasma pneumonia with levofloxacin, steroids and rigorous physiotherapy.

Conclusions
Accurate clinical acumen along with timely radiological imaging is the need of the hour for early diagnosis of macrolide-resistant mycoplasma pneumonia (MRMP). This case also emphasises role of fluoroquinolones and steroids in treatment of macrolide-resistant mycoplasma pneumonia.
Hospital at home: emergence of a high-value model of care delivery
Authors: Kanagala Sai Gautham , Gupta Vasu , Kumawat Sunita , Anamika FNU , McGillen Brian , Jain Rohit 
Published: March 2023

Abstract

Background
With increasing healthcare demands for acute illness in patients especially in the times of pandemic, healthcare organizations require modern solutions. Hospital at home (HaH) is one such tool that has the potential to solve these problems without compromising the care of the patients.

Main body
Hospitals have been the conventional setting for managing acute sickness patients; however, it could be a very challenging environment for a few patients, especially for the older population who are highly susceptible to hospital-acquired infections. Health care in a hospital setting can also be very expensive, as it often involves a lot of healthcare professionals providing care. HaH service can provide the same quality of care expected in traditional settings.

Conclusions
The median length of stay and the rate of readmissions were lower in people under HaH care. Compared with patients in a hospital setting, patients in HaH had better clinical outcomes. HaH unit provides an integrated, flexible, easy-to-scale platform that can be cost-effectively adapted to high-demand situations.
Managing unpredictable challenge of a metastatic nodule in radiation treatment field—a case report
Authors: Sikdar Debanjan , Gupta Sweety , Charavarty Abhishek , Kaushik Bhoomika , Joseph Deepa M. , Gupta Manoj 
Published: March 2023

Abstract
Background
Despite the high prevalence of locally advanced head and neck cancer, treatment failure in the form of a cutaneous deposit in the treatment field during radiation is not common. There has never been a cytology-proven published case of marginal treatment failure in the cutaneous region during radiotherapy.

Case presentation
A 51-year-old male patient was diagnosed with squamous cell carcinoma of the left tonsillar fossa. After a partial response to induction chemotherapy, the patient was treated with definitive chemo-radiotherapy. After the 23rd fractionation of radiotherapy, there was a clinical progression in the form of a solitary skin nodule within the treatment field, which was further treated with an electron boost to a total dose of 70 Gy followed by palliative chemotherapy.

Conclusion
During definitive chemoradiotherapy, failure outside the high-dose radiation field is not common, and a skin nodule during treatment had never been described. Our case demonstrates the importance of performing thorough clinical examinations on a weekly basis, not only for toxicity assessment but also for treatment response.