bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early and sustained efficacy of fremanezumab over 24-weeks in migraine patients with multiple preventive treatment failures. The multicenter, prospective, real-life FRIEND2 study.
Authors: Barbanti Piero , Egeo Gabriella , Aurilia Cinzia , Torelli Paola , Finocchi Cinzia , d'Onofrio Florindo , d'Onorio Luigi , Rao Renata , Messina Stefano , Clemente Laura Di , Ranieri Angelo , Autunno Massimo , Sette Giuliano , Colombo Bruno , Carnevale Antonio , Aguggia Marco , Tasillo Miriam , Zoroddu Francesco , Frediani Fabio , Filippi Massimo , Fiorentini Giulia , Tomino Carlo , Proietti Stefania , Bonassi Stefano 
Published: January 2023

Abstract
Background
To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥8 days/month) or chronic migraine (CM: ≥15 days/month), and multiple preventive treatment failures.
Methods
This is a prospective, cohort, real-life study at 28 headache centers on consecutive patients affected by HFEM or CM with multiple preventive treatment failures who were prescribed subcutaneous fremanezumab (225 mg monthly/675 mg quarterly) for ≥ 24 weeks. Primary endpoint was the change in monthly migraine days (MMDs) in HFEM and monthly headache days (MHDs) in CM at weeks 21–24 compared to baseline. Secondary endpoints encompassed changes in monthly analgesic medications, ≥ 50%, ≥ 75%, and 100% responder rates, and variation in NRS, HIT-6 and MIDAS scores at the same time interval. Changes in MMDs/MHDs, monthly analgesic medications, ≥ 50%, ≥ 75%, and 100% responder rates, and variation in NRS and HIT-6 scores at week 4 were also monitored.
Results
410 patients who had received ≥ 1 dose of fremanezumab were considered for safety analysis while 148 patients treated for ≥ 24 weeks were included in the efficacy analysis. At weeks 21–24, fremanezumab significantly (p < 0.001) reduced MMDs, MHDs, monthly analgesic medications and NRS, HIT-6, and MIDAS scores in both HFEM and CM compared to baseline. The proportions of ≥ 50%, ≥ 75% and 100% responders at weeks 21–24 were 75.0%, 30.8%, 9.6% (HFEM), and 72.9%, 44.8% and 1% (CM). A significant (p < 0.001) decrease in MMDs, MHDs, monthly analgesic medications and NRS, HIT-6, and MIDAS scores in both HFEM and CM was already present at week 4. The proportions of ≥ 50%, ≥ 75%, and 100% responders at week 4 were 67.6%, 32.4%, 11.8% (HFEM) and 67.3%, 40%, 1.8% (CM). CM remitted to episodic migraine and medication overuse to no-medication overuse in 83.3% and 75% of patients at week 24, and in 80% and 72.4% at week 4. Adverse events were rare (2.4%), mild and transient. No patient discontinued treatment for any reason.
Conclusions
Fremanezumab is characterized by an early and sustained efficacy in HFEM and CM patients with multiple preventive treatment failures in real-life, revealing an optimal safety and tolerability profile.
Return of Participants' Incidental Genetic Research Findings: Experience from a Case-Control Study of Asthma in an American Indian Community
Authors: Best Lyle G. , O'Leary Marcia , O'Leary Rae , Lawrence Wendy , Torgerson Dara G. 
Published: January 2023

Abstract
Purpose: The proper communication of clinically actionable findings to participants of genetic research entails important ethical considerations, but has been challenging for a variety of reasons. We document an instance of return of individual genetic results in the context of a very rural American Indian community, in hopes of providing insight to other investigators about potentially superior or inferior courses of action.
Methods: The original study was a case/control study of asthma among 324 pediatric participants. The study utilized a genotyping microarray assessing over 2 million variants, including one conferring risk for hypertrophic cardiomyopathy for which the American College of Medical Genetics recommends return of results to participants. The study investigators engaged in extensive consultation with the IRB, the Tribal government and local clinicians to better inform our approach.
Results: With some difficulty we were able to notify the 2 participants heterozygous for this variant. One participant welcomed this information and proceeded to obtain further clinical work-up; the other participant declined further follow-up.
Conclusion: While demanding of considerable time and effort, the return of clinically actionable genetic results is important from both an ethical perspective and to provide an improved trust relationship with the community of research participants.
Practical biomarkers and robust multiplex models for the prediction of response to the promising first-line chemotherapy: A theranostic study in metastatic ovarian cancer patients with residual peritoneal tumors
Authors: Kawabata-Iwakawa Reika , Iwasa Norihiro , Satoh Kenichi , Colinge Jacques , Shimada Muneaki , Takeuchi Satoshi , Fujiwara Hiroyuki , Eguchi Hidetaka , Oishi Tetsuro , Sugiyama Toru , Suzuki Mitsuaki , Hasegawa Kosei , Fujiwara Keiichi , Nishiyama Masahiko 
Published: January 2023

AbstractBackground: In advanced or metastatic ovarian cancer patients, the therapeutic impact of molecular targeted agents and immunotherapy is limited, and current chemotherapeutic algorithm is still far from personalized medicine. We recently demonstrated that intraperitoneal carboplatin with dose-dense paclitaxel (ddTCip) therapy is a promising front-line chemotherapy even in the patients with residual peritoneal tumors, which led us to this theranostic study for biomarker discovery to realize the precision medicine (ID: UMIN000001713 on Feb 16 th , 2009). Methods: We first validated previously suggested markers (41 genes and 3 predictive models for the therapeutic efficacy and 31 polymorphisms for the toxicity), sought out more active effective biomarkers through genome-wide transcriptome and genotyping analyses, and then developed multiplex statistical prediction models for progression free-survival (PFS) and toxicity. Multiple regression analysis following forward stepwise method and Classification and Regression Trees (CART) algorithm were mainly employed to develop multiplex prediction models. Results: The association analyses with PFS in 76 patients followed by the validation study using data sets in 189 patients published in The Cancer Genome Atlas revealed that SPINK1 expression could be a possible predictive biomarker of ddTCip efficacy even when used alone, and multiple regression analyses provided a potent efficacy prediction model using expression data of 5 genes. SPINK1 appeared to be a critical resistant determinant of ddTCip therapy, which indicates the potential of SPINK1 also to be a novel therapeutic target. As for the toxicity prediction, ABCB1rs1045642 and ERCC1rs11615 polymorphisms appeared to closely associate with grade2-4 hematologic toxicity and peripheral neuropathy, respectively. We further successfully composed robust multiplex prediction models for the adverse events-CART models using a total of 4 genotype combinations and further powerful multiple regression models using 15 polymorphisms on 12 genes-. Conclusions: We newly proposed SPINK1 expression as a powerful predictive biomarker of the efficacy for ddTCip therapy and confirmed the predictive values of ABCB1 and/or ERCC1 polymorphisms for the toxicity. Multiplex prediction models composed herein were also found to work well for the prediction of therapeutic response. These may raise the potential to realize a precision medicine in the essential treatment for metastatic ovarian cancer patients.
Effects of exposure to incense smoke associated with impaired lung function and respiratory disease: A Systematic Review
Authors: Adnyana I Made Dwi Mertha , Utomo Budi , Dewanti Linda , Lagoa Ricardo , Fauziyah Shifa , Eljatin Dwinka Syafira , Setyawan Muhamad Frendy , Sumah Lesty Helda Marsel , Karina Citra Al 
Published: January 2023

Abstract
Incense (bakhour) is used by the community through ceremonies, traditional health practices, and aromatherapy. Nevertheless, evidence from experiments and studies of populations suggests that a habit of burning incense makes the lungs work less well. The study investigated the relationship between exposure to incense smoke and impaired lung function and respiratory diseases. Data tracing was carried out systematically by following PRISMA guidelines and establishing inclusion and exclusion criteria for filtering, selecting, and including articles registered in the PROSPERO database. This study describes respiratory symptoms/ diseases, home use of incense, and lung function measurement. Six articles were included; 6 articles (100%) reported using incense indoors, and five (83%) reported using incense outside the home. Respiratory symptoms and diseases caused by exposure to incense sticks are 5 (83%) shortness of breath, 6 (100%) wheezing, asthma, and inflammation of the lungs, 2 (33%) chronic obstructive pulmonary disease, and 4 (67%) allergic rhinitis. Incense smoke particles decrease lung function based on FVC, FEV, PEFR, and FEF values of 25–75%. The results indicate that smoking incense adversely affects lung function and leads to respiratory diseases. The community and related parties can minimize and conduct education and prevention related to simultaneous incense exposure in the community to reduce the burden of diseases and disorders due to respiratory incense smoke in areas that use it daily.
Observer Effect in Social Media Use
Authors: Saha Koustuv , Gupta Pranshu , Mark Gloria , Kıcıman Emre , De Choudhury Munmun 
Published: January 2023

Abstract
Research has revealed the potential of social media as a source of large-scale, verbal, and naturalistic data for human behavior both in real-time and longitudinally. However, the in-practice utility of social media to assess and support wellbeing will only be realized when we account for extraneous factors. A factor that might confound our ability to make inferences is the phenomenon of the ``observer effect''---that individuals may deviate from their otherwise typical social media use because of the awareness of being monitored. This paper conducts a causal study to measure the observer effect in longitudinal social media use. We operationalized the observer effect in two dimensions of social media (Facebook) use---behavioral and linguistic changes. Participants consented to Facebook data collection over an average retrospective period of 82 months and an average prospective period of 5 months around the enrollment date to our study. We measured how they deviated from their expected social media use after enrollment. We obtained expected use by extrapolating from historical use using time-series (ARIMA) forecasting. We find that the deviation in social media use varies across individuals based on their psychological traits. Individuals with high cognitive ability and low neuroticism immediately decreased posting after enrollment, and those with high openness significantly increased posting. Linguistically, most individuals decreased the use of first-person pronouns, reflecting lowered sharing of intimate and self-attentional content. While some increased posting about public-facing events, others increased posting about family and social gatherings. We validate the observed changes with respect to psychological traits drawing from psychology and behavioral science theories, such as self-monitoring, public self-consciousness, and self-presentation. The findings provide recommendations to correct observer effects in social media data-driven assessments of human behavior.
Mitochondrial dynamics in the rat dorsal raphe nucleus underlie sleep pressure and sleep structure regulation
Authors: Zhao Hui-Ling , Hu Xiao , Kurban Nurhumar , Qin Yu , Chen Xi , Ding Yu-Qi , Liu Xing-Yu , He Jun-Ming , Peng Yu-Shuo , Yang Xin-Di , Cui Su-Ying , Zhang Yong-He 
Published: January 2023

Abstract
Circadian rhythm and sleep homeostasis processes regulate sleep and wakefulness in mammals, which are highly interconnected with serotonergic circuits that originate in the dorsal raphe nucleus (DRN). Higher serotonin levels during wakefulness may exert “sleep pressure” and lead to sleep onset, but the mechanisms are unclear. Proteomics analysis indicated that mitochondria are key mediators. The present study found that an increase in mitochondrial fission and oxidative phosphorylation/electron transfer capacity were coupled with a reduction of sleep pressure in rats. When mitochondrial fission was moderately inhibited, wake-promoting and non-rapid-eye-movement sleep-enhancing effects were found to result from the activation of serotonergic function. These findings indicate that sleep homeostasis is highly integrated with the mitochondrial dynamic process in the rat DRN. Our findings support a conceptual framework by which mitochondria and energy metabolism in the rat DRN are introduced into the serotonergic modulation of sleep-wake states and provide evidence of sleep evolution from an energy-balance perspective.
Pathways to clean energy transition in Indonesia's electricity sector with OSeMOSYS modelling (Open-Source Energy Modelling System)
Authors: Paiboonsin Pusanisa 
Published: January 2023

Abstract
Responding to the Paris agreement and climate change mitigation, Indonesia aims to reach Net Zero by 2060 or sooner. Due to Indonesia's dependence on coal and growing consumption, alternative sources of clean energy are imperative for meeting its rising energy needs and reducing energy-related greenhouse gas emissions to achieve the energy transition. This project aims to examine Indonesia's challenges, opportunities and potential to achieve low carbon ambition in the energy sector and identify alternative pathways for the energy transition in Indonesia. Cost-effective scenarios are developed by the Open Source Energy Modelling System (OSeMOSYS), providing comprehensive data analysis. OSeMOSYS is a least-cost model that enables long-term energy system modelling and its related intensive analysis. Indonesia energy data and OSeMOSYS input are obtained from an Indonesia starter data kit. In this study, a comparison of electricity generation, technology, investment, and carbon dioxide emissions is made between business-as-usual scenarios and model scenarios. The results show that NZ50 scenario is more cost-effective than others in meeting Indonesia's future energy demand at the lowest implementation cost. Although NZ50 and NZ60 are possible ways to reach carbon neutrality, NZ50 emits fewer CO2 emissions at a similar cost to NZ60. This paper's insights emphasise that large-scale renewable energy deployment and coal retirement are critical pathways to reaching carbon neutrality and achieving the energy mix transition.
Factors affecting the performance of household rainwater harvesting systems in the south-western coastal region of Bangladesh
Authors: Ghosh Shimul , Ahmed Tanvir 
Published: January 2023

Abstract
This study aims to evaluate the post-installation performance of household (HH) rainwater harvesting (RWH) systems in the southwestern coastal region of Bangladesh. A conceptual framework for evaluating the effectiveness of RWH systems was developed based on seven determinants. An application of multivariable logistic regression showed that family size, monthly income, the practice of tank and downpipe cleaning, and the organizations supporting the installation were the most significant parameters (p&lt; 0.05) affecting the effectiveness of the RWH systems. A family size of 1–4 has higher odds of having a properly functioning system (adjusted odds ratio (AOR) = 28.3; 95% confidence interval (CI) = 4.8–167.7) than a family of 9 or more. The practice of tank cleaning once per year (AOR = 3.3; 95% CI = 1.2–9.1) and downpipe cleaning more than 3 times/year (AOR = 9.7; 95% CI = 1.5–62.5) had higher odds than HHs practicing no cleaning at all. RWH systems installed by institutions other than the Department of Public Health Engineering, and NGOs had higher odds (AOR = 22.0; 95% CI = 2.3–213.0) compared to systems installed on their own. This study provides clues to strengthening the existing RWHS intervention programs in the water-challenged regions of Bangladesh.
Availability and accessibility of toilet facilities among low-income households in selected settlements of Cape Coast Metropolis, Ghana
Authors: Kipkoech Rogers , Takase Mohammed , Aliyu Aminu , Kibet Joy , Mugah Faith 
Published: January 2023

AbstractCape Coast Metropolis faces a serious lack of adequate toilet facilities among the low-income households, leading to poor sanitation, health, and environmental degradation. The research explored and provided valuable data on the availability and accessibility of toilet facilities among low-income households. Using a simple random sampling technique,100 closed-ended questionnaires were equally administered to respondents in four Cape Coast Metropolis communities. Descriptive statistics were used to assess the types of toilet facilities available, identify the accessibility of toilet facilities, and ascertain challenges in providing toilet facilities. Spearman's correlation coefficient was used to explore the relationship between income source and toilet facilities in the households. All statistical analysis was done using SPSS version 21. The findings were presented in form of tables and figures. The results reveal a significant lack of toilet facilities among the residents. Regarding the level of accessibility, most adults (79%) and children (72%) used household toilet facilities for defecation, while 14% of adults and 16% of children in the household were using toilet facilities outside the household. Open defecation near the house was more prevalent among the children (11%) than adults (6%) which shows unwillingness by most families to invest in improve toilet facilities.
Bedaquiline’s Safety Profile Monitoring in India: Considerations for
Future - A Systematic Review
Authors: Thangaraju Pugazhenthan , Velmurugan Hemasri , Yella Sree Sudha Tanguturi 
Published: January 2023

Background:
Tuberculosis is still one of the top causes of infection-related death globally.
Drug-resistant tuberculosis has a high mortality rate and is still a serious public health concern
around the world. The appearance of multidrug-resistant and extensively drug-resistant strains
of tuberculosis has increased the need for new therapeutic options against these strains. Most of the
drugs used to treat them have been poorly tested and have serious negative effects. Patients with
drug-resistant tuberculosis have been fighting for access to experimental medications, particularly
bedaquiline.

Objective:
The study aimed to summarise the existing evidence of bedaquiline's safety on drugresistant
tuberculosis treatment outcome and look for bedaquiline-related adverse drug reactions in
the Pharmacovigilance Programme of India and World Health Organisation - Uppsala Monitoring
Centre database.

Methods:
We searched the PubMed database for relevant studies on the safety profile of bedaquiline
used in the treatment of drug-resistant tuberculosis and bedaquiline-related adverse drug reactions
in the Pharmacovigilance Programme of India and World Health Organisation - Uppsala
Monitoring Centre database published up to April 25, 2022.

Results:
A total of 190 abstracts were identified through the Pubmed database. In a list of 157 fulltext
eligible articles assessed, 149 were excluded as they did not meet the inclusion criteria. The
complete articles of the remaining 8 studies were further evaluated. There were 4 prospective
cohorts, 2 retrospective cohorts, and 2 case series.

Conclusion:
Pharmacovigilance and medication safety monitoring of newer treatments, like bedaquiline,
are critical for enhancing treatment support and adherence, especially among drugresistant
tuberculosis patients.
Future Perspectives of Wharton’s Jelly Mesenchymal Stem Cells and their
Soluble Factors in Radioprotection
Authors: Maurya Dharmendra Kumar , Sandur Santosh Kumar 
Published: January 2023

Abstract:
Acute radiation syndrome (ARS) is also known as triple syndrome, which develops after
whole-body radiation exposure. During unforeseen exposures, these syndromes are set in depending on
the dose of radiation. Cell-based therapy, especially using stem cells and their soluble factors, is gaining
wide attention in the field of regenerative medicine to treat various diseases, including degenerative diseases.
Stem cells attract prime attention because of their profound inherent tissue repair capability and
regeneration potential. Further, stem cell therapy can be one of the promising strategies for the amelioration
of ARS because of its ability to lodge in damaged tissue and release regenerative cytokines by sensing
the local injury. In this regard, human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs)
have gained substantial attention for their applications in the treatment of various human diseases due to
several advantages offered by them. This article is intended to provide future perspective on the use of
WJ-MSCs for the management of accidental radiation injury in pre-clinical models, and finally, their
utility in regeneration of damaged tissues and organs.
GC-MS (Gas chromatography and mass spectroscopy) analysis of methanol leaf extract of Rhododendron arboreum Sm. of District Sirmaur, Himachal Pradesh
Authors: Prakash Ved 
Published: January 2023

Plants are a rich source of secondary metabolites or chemical constituents with interesting biological activities. Therefore, a thorough validation of the herbal agents has emerged as a new branch of science emphasizing and prioritizing the standardization of the natural drugs and products because several of these phytochemicals have complementary and overlapping mechanism of action. Mass spectrometry coupled with chromatographic separations such as Gas chromatography (GC-MS) is generally used for direct analysis of components existing in traditional medicines and medicinal plants. Gas chromatography separates the components of the mixture and mass spectroscopy analyses each of these components separately. In recent years, GC-MS studies have been increasingly applied for the analysis of medicinal plants as this technique has proved to be a valuable method for the analysis of non-polar components, volatile essential oils, fatty acids, lipids, alkaloids etc. The present study was aimed to find out the bioactive compounds present in methanol extract of Rhododendron arboreum Sm. by using Gas chromatography and Mass spectroscopy. GC-MS chromatogram showed 10 peaks indicating the presence of ten phytochemical constituents in this plant. The results revealed Limonene (18.48%), Caryophyllene (13.01%), 3-Heptanoicacid methyl ester (11.00%) and Phenol, 2-(2-methyl-2-propenyl) (5.52%) as the major components in the methanol extract. The results support the use of R. arboreum in traditional medicines for controlling bacterial, degenerative and other diseases. Thus, the present study approves the medicinal value of this plant and scientifically validates it for use as a component of medicinal preparations.
Keywords: Rhododendron arboreum, methanol, leaf extract, phytochemicals, Gas chromatography and Mass spectroscopy (GC-MS)