bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of probiotic supplementation (Saccharomyces cerevisiae) on pancreatic alpha and beta cells and energy metabolic profile in broilers
Authors: Peña Silvana J. , Salazar Johan S. , Pardo Jhon F. , Roa Maria L. , Corredor-Matus José R. , Ochoa-Amaya Julieta E 
Published: May 2023

Abstract
The use of growth-promoting antibiotics has increased bacterial resistance, making made it urgent to look for options in nutritional supplementation with probiotics. This, in turn, can contribute to improving nutrition as well as welfare of broilers.
Objective: To assess the effect of supplementation with Saccharomyces cerevisiae (SC) on areas of islets of Langerhans and alpha and beta cells (α- and β-cells) in broilers by immunohistochemistry (IHC). To correlate areas of α- and β-cells in relation to pancreatic islet area, glucose, and insulin in both SC-supplemented and control groups. To correlate data obtained for triglycerides, total, HDL, and LDL cholesterol, and histological parameters of vacuolar assessment in central splenic arteriole and coronary arteries in both treatments.
Materials and Methods: Two treatments were assessed: T1 (control group without probiotics; n = 10) and T2 (group treated with Saccharomyces cerevisiae; n = 14). Islet areas were measured according to the number of islets established per animal, with number of islets per individual equal to five for groups T1 (n = 10) and T2 (n = 14). Alpha and beta cells were measured by IHC (40x) with primary anti-glucagon (clone EP74) and anti-insulin (clone EP125) antibodies. Serum glucose and insulin were determined by spectrophotometry. Statistical analysis employed "t" tests for unpaired samples and Pearson’s correlation.
Results: HDL cholesterol increased in T2 (14.54 ± 0.979) (p = 0.0365) as compared to T1 (12.20 ± 0.8424) mg/dL. Glycemia decreased in T2 (p = 0.01) (244.7 ± 7.5) vs. T1 (297.9 ± 21.18).
Conclusion: Dietary supplementation with Saccharomyces cerevisiae (CS) decreased serum glycemia without affecting insulin. It modified the correlation of areas of pancreatic cell population in islets of Langerhans and enlarged areas of α-cells vs. β-cells, thereby maintaining blood glucose homeostasis. In addition, SC increased levels of high-density cholesterol (HDL) in the blood.
Financial support: General Directorate of Research at Universidad de los Llanos.
Chili pepper extracts as potential anticancer agents targeting topoisomerases
Authors: HUDÁKOVÁ Terézia , ŠEMELÁKOVÁ Martina , OČENÁŠ Peter , KOŽURKOVÁ Mária , KROCHTOVÁ Kristína , SOVOVÁ Simona , TÓTHOVÁ Zuzana , GUĽÁŠOVÁ Zuzana , POPELKA Peter , SOLÁR Peter 
Published: May 2023

Abstract
This study aimed to explain the effect of extracts from chili pepper varieties containing capsaicin and dihydrocapsaicin, among other substances, on the growth of colon cancer in humans through therapeutic research and drug screening. DNA topoisomerases regulate conformational changes in DNA topology during normal cell growth, such as replication, transcription, recombination, and repair, and may be targeted for anticancer drugs. A DNA topology assay was used to investigate DNA-damaging/protective activities of extracts from Habanero Red (HR), Habanero Maya Red (HMR), Trinidad Moruga Scorpion (TMS), Jalapeno (J), Serrano (SP), Habanero Red Savina (HRS), Bhut Jolokia (BJ), and Jamaica Rosso (JR) peppers, demonstrating their inhibitory effect on the relaxation of pBR by Topo I. DNA topoisomerase II (Topo II) is proven therapeutic target of anticancer drugs. Complete inhibition of Topo II was observed for samples TMS, HR, and HMR. Extracts J and SP had the lowest capsaicin and dihydrocapsaicin content compared to other peppers. HR, HMR, TMS, J, S, HRS, BJ, JR extracts showed the antiproliferative effect, examined by MTS and xCell assay on the in vitro culture of the cancer cell line HCT116.
Comparison of Bb With Meta-heuristic Approach in Optimization of Three Stage Fss With Multiple Processors
Authors: Malhotra Khushboo , Gupta Deepak , Goel Sonia , Tripathi A. K. 
Published: May 2023

Abstract
Flow shop scheduling model (FSSM) is an important area of research in the field of Scheduling theory and it has many real applications in the industrial field. This study involves flow shop scheduling problem having machines on three levels in which utilization time of each task is considered as fuzzy triangular number. The concept of like parallel machines at each stage is also considered. Unit operational costs of jobs are also involved. The goal of this research is to recommend a heuristic approach inspired by Genetic algorithm (GA) which on implementation, provides an optimal or near-optimal schedule to reduce the make-span. Numerical example is also given to establish the usefulness of the proposed approach, and to approve the presentation, the results are compared with the existing methods like Branch and Bound (B & B).
Immune humanized mice reconstituted with peripheral blood mononuclear cells or hematopoietic stem cells develop distinct MDA-MB-231 tumor immune microenvironments
Authors: Wang Angela Jui-Ling , Chen Yi-Ting , Ma Wen-Hui , Liao Chia-Chi , Chiang Tien-Huang , Yu Chun-Keung , Su Yu-Chia 
Published: May 2023

Abstract
Triple-negative breast cancer (TNBC) is one of the most fatal subtype of breast cancer. Tumor immune microenvironments (TIMEs) have critical influences on TNBC therapies. However, syngeneic mouse tumor models are insufficient to evaluate immunotherapeutic efficacy, because the different immune responses between mice and human. Therefore, human xenograft tumor mouse models with humanized immune systems (HIS) are more suitable for evaluation of immunotherapeutic efficacy. In these study, two immune humanized mouse models transferred with human hematopoietic stem cells (hHSC-HIS) or human peripheral mononuclear cells (hPBMC-HIS) in our advanced severe immune deficiency (ASID) mice were generated. Both systemic immune profiling and TIMEs of TNBC MDA-MB-231 tumors from hHSC- and hPBMC-HIS ASID models were compared. Generation of the comprehensive human immune system and large amounts of human macrophages/bone marrow-derived stromal cells around the TIMEs were noted in hHSC-HIS ASID mice, but the growth of TNBC was not affected. In contrast, T cells dominated the systemic immune system and TIMEs in hPBMC-HIS ASID mice, and inhibited the tumor growth. In summary, the TIMEs of hHSC-HIS ASID model is suitable for validations of immunotherapies reversing immune suppression. The TIMEs of hPBMC-HIS ASID can be applied for cytotoxicity test of tumor specific T cells.
Distributed Adaptive Global Stabilization of a Class of Rigid Formation Systems
Authors: Wang Qin , Chen Zitao , Yi Yang , Shen Mouquan , Yang Jun 
Published: May 2023

Abstract
This paper proposes a distributed globally stable control strategy for a class of rigid formation systems. Specifically, the multiple equilibrium problem of distance-based formation control is solved for a class of rigid formation systems. Firstly, a scalable algorithm is given to check if the proposed rigid graph satisfies the specific structure and determine that each follower has only two neighbors to form a cascade interconnection. Secondly, according to the cascade structure induced by the given algorithm, the distributed perturbed gradient control law and the adaptive law are presented for the rigid formation system. Finally, the global convergence and stability properties are obtained using the cascade system stability theory and adaptive control theory. Simulations are provided to demonstrate the effectiveness of the globally asymptotically stable formation control strategy.
The Transcriptome Induced by Bazhen Decoction and its Function in G-quadruplex Resolving and Telomere Maintenance in Progeroid Cells
Authors: Li Chuanbiao , Tian Jie , Yang Jun , Wang Qianqian , Guo Bing , Huang Liming , Hu Ying , Luo Ying 
Published: May 2023

Abstract

BackgroundThe Bazhen decoction is one of the most extensively used Traditional Chinese medicine (TCM) prescriptions for anti-aging. However, due to the complicity of the components, the pharmacological mechanism of Bazhen decoction is still limited.MethodsWe applied RNA sequencing and transcriptome analysis to get the full view of the signaling pathways regulated by Bazhen decoction in the wild type cell background. By using the progeroid cells derived from Werner syndrome mice, we applied Western blot, Immunofluorescence, flow cytometry and telomere FISH to verify the transcriptome data.ResultsThe transcriptome profile revealed that Bazhen decoction might systematically regulate multiple anti-aging pathways, including stem cell regulation, protein homeostasis, cardiovascular function, neuronal function, anti-inflammation, anti-DNA damage induced stress, DNA helicase activity and telomere lengthening. We found that multiple DNA helicases and telomere regulating proteins were up-regulated by Bazhen decoction, which promoted the resolving of G-quadruplex (G4) structure, and facilitated DNA replication and telomere elongation. These improvements also endowed the cellular resistance to DNA damages induced by replication stress. Together these data suggest that Bazhen decoction facilitate G4 resolving and telomere maintenance, which might contribute to the longevity sustaining properties revealed by transcriptome profile.ConclusionsOur data revealed a new strategy for recovering the pharmacological signature pathways for TCM, which could help the clinical precision medicine of TCM. By applying transcriptome in TCM-treated normal cell, we tried out a systematic analysis for dissecting the molecular mechanism of complicated TCM prescription in the normal genetic background.
High-throughput Design of a Lightweight and Ultra-strong Refractory Eutectic High-Entropy Alloy with Outstanding Irradiation Resistance
Authors: Liaw Peter , Yang Chao , Wang Beiyang , Shen Gaoyuan , Wei Tao , Wu Mingxu , Tao Qingzhou , Wang Shubin , Shu Da , Sun Baode 
Published: May 2023

Abstract
Lightweight, strong, and radiation-tolerant materials are essential for advanced nuclear systems and aerospace applications. However, the current research for these materials mainly focuses on a single design strategy to improve their irradiation resistance via empirical trial-and-error learning. In this study, a novel NbVTaSi refractory eutectic high-entropy alloy was target designed via high-throughput thermodynamic calculations. To exploit the unique eutectic structures of NbVTa and β-Nb5Si3 phases, a new synergistic mechanism for irradiation resistance via balancing inhibition effects on the generation of He-induced lattice defects and the formation and growth of He bubbles was proposed according to the experimental findings and density functional theory calculations. The alloy possesses lightweight (7.4 g/cm3), high yield strengths at room temperature (2.60 GPa) and 850 ℃ (1.84 GPa), and outstanding He-irradiation resistance, superior to other reported radiation-resistant alloys. This study sheds light on the development of future radiation-tolerant materials for advanced nuclear systems and aerospace applications.
Design of Sports Multimedia Teaching Platform Based on machine learning
Authors: Luo Changwei 
Published: May 2023

Abstract
Due to the rapid development of multimedia technology, communication technology and information technology in China, scholars in the field of education gradually focus their research on new educational models, which are represented by educational technology and can use multimedia to present internal forms, such as physical education. Therefore, under this background, this paper deeply develops a kind of PE teaching platform based on multimedia network system by combining modern communication technology, multimedia technology, computer technology, network technology and other mature college campus networks. Firstly, this paper investigates the design of machine learning decision tree algorithm and random forest algorithm, and discusses the application of machine learning in multimedia feature extraction and data processing; Then according to the actual needs, the structure of sports multimedia teaching platform is constructed, the relevant functions are analyzed, and the results of QoE multimedia experiment are integrated and tested. After the establishment of sports multimedia teaching platform, this paper uses this platform to practice, so as to analyze the teaching skills of physical education teachers in sports multimedia teaching platform, evaluate students' satisfaction, and discuss the application of multimedia teaching platform in sports teaching and the performance and influencing factors of the system with students. The experimental results show that the sports multimedia teaching platform proposed in this paper has a certain role in promoting the improvement of College Students' physical education curriculum performance, so it is worth popularizing.
Dietary Vitamins and DMFT index in Rafsanjan adults, a Cross- sectional Study on Rafsanjan Adults Cohort Data
Authors: Sardari Farimah , Khalili Parvin , jamali Zahra , Rezvaninejad Rayehehossadat , Rezvaninejad Raziyehsadat , Eslami Amirhosein 
Published: May 2023

Abstract
Introduction: Vitamins are generally known to be important in oral health. Some associations have been found between vitamins and dental caries, but these findings have been controversial so far. This study aimed to investigate the associations of dietary intakes of vitamins and DMFT index.
Methods and materials: In this cross-sectional study, the study population was 3028 subjects aged 35-70 years from Rafsanjan Cohort Study's Oral Health Branch (OHBRCS) which is a branch of Rafsanjan Cohort Study (RCS). RCS is a part of the prospective epidemiological research studies in IRAN (PERSIAN). Subjects’ demographic information, variables related to oral health, history of underlying diseases, history of smoking, alcohol, and opium use based on questionnaires and checklists produced by the Persian cohort team was obtained and also dietary intakes of vitamin A, vitamin E and vitamin B family were collected by a validated food frequency questionnaire. Linier regression analysis was used to investigate the association between intake of dietary vitamins and DMFT (Decayed, Missing, and filled Teeth) using crude and adjusted models.
Results: The findings showed low levels of education and socio-economic status, older age, smoking and opium consumption, and decreasing the frequency of brushing are significantly associated with an increase in the DMFT index. DMFT index were more unfavorable in people with dietary intake ≤ median of all measured vitamins. In fully adjusted model, DMFT index showed a significant negative relationship with dietary intakes of Vitamin A, β_carotene, lutein_zea xanthin, Vitamin E, Vitamin K, thiamin, Vitamin B6, and folate (Unstd.B =-0.54, 0.63,0.86,0.49,0.88,0.63,0.66,0.54,respectively).
Conclusion: Increasing the intake of Vitamin A, β_carotene, lutein_zea xanthin, Vitamin E, Vitamin K, thiamin, Vitamin B6, and folate may be associated with the low DMFT index, so it is recommended to use more this category of vitamins.
A Study on the Facade Decorative Pattern of Modern Buildings in Kulangsu Taking the Gate House Decoration as an Example
Authors: Qian Yi , Hu Shen 
Published: May 2023

Abstract
The architectural decoration of Kulangsu is complex and magnificent, including the characteristics and styles of classicism, eclecticism, traditional style of southern Fujian, and decorative style of Amoy. It is a treasure house of architectural decoration patterns. At the same time, the development of Kulangsu architecture is the same as the internationalization of modern architecture. Therefore, many modern style gatehouse decoration appeared in the buildings of Kulangsu. Based on the outline of the gate building, the way of arching and the significance of decorative patterns, this paper traces its origin and analyzes its geometry. The geometric relationship in the decoration of the gate house on Kulangsu Island is sorted out, and the gate house style and the gate house mountain flower style are specifically and systematically classified. It is hoped that the relationship between overseas Chinese, local residents and colonists in Southeast Asia can be explained by tracing the origin of architectural decoration.
The Long-term Impact of Post-Operative Oral Contraceptive Recommendations After Laparoscopic Cystectomy of Endometrioma on the Incidence of Endometrioma Recurrence and Ovarian Cancer Development
Authors: Maki Eiko , Takamura Masashi , Koga Kaori , Izumi Gentaro , Satake Erina , Takeuchi Arisa , Makabe Tomoko , Haraguchi Hirofumi , Harada Miyuki , Hirata Tetsuya , Hirota Yasushi , Wada-Hiraike Osamu , Osuga Yutaka 
Published: May 2023

Abstract
Background Previous studies have shown the ovarian carcinoma after laparscopic cystectomy of endometrioma arises through the recurrence of endometrioma. Then it can be assumed that reduction of ovarian endometrioma recurrence through postoperative medication can lead prevention of carcinogenesis. Therefore, this study aimed to evaluate the long-term impact of oral contraceptive (OC) recommendation after laparoscopic cystectomy of endometrioma on the incidence of endometrioma recurrence and ovarian cancer development.Methods This retrospective study included 546 patients who underwent laparoscopic cystectomy of ovarian endometrioma at a tertiary referral hospital to evaluate the OC recommendation following laparoscopic cystectomy of endometrioma introduced after the year 2005.Results This study included 218 patients in the pre-recommendation group and 328 patients in the post-recommendation group. Patient characteristics (age, gravida, parity at surgery, comorbidity of uterine fibroids and adenomyosis, revised American Society for Reproductive Medicine score, cyst size, and bilateral involvement) were comparable between the groups. Postoperative OC was recommended to be started and continued for at least 2 years in 3.2% of patients in the pre-recommendation group and 38.7% of patients in the post-recommendation group. The endometrioma recurrence rate was significantly lower in the post-recommendation group (3.8% per year) than in the pre-recommendation group (6.8% per year, p < .001). The incidence of ovarian cancer was lower in the post-recommendation group (0.063% per year) than in the pre-recommendation group (0.248% per year), although this difference was not significant. None of the patients who had used OC for > 2 years developed ovarian cancer.Conclusions Introduction of the postoperative OC recommendation after laparoscopy significantly reduced the recurrence rate of endometrioma, and tended to reduce the incidence of ovarian cancer.
In it Together: Sense of Community and Psychologic Distress During COVID-19
Authors: Wu Kimberly , Doe Erica , Roude Gabriela , Wallace Jasmine , Francois Samantha , Richardson Lisa , Theall Katherine 
Published: May 2023

Abstract
We assessed the relationship between differences in indicators of social capital before and during the COVID-19 pandemic, and their association with self-reported measures of psychological distress. The data was analyzed from an existing cluster randomized control trial (the Healthy Neighborhoods Project) with 244 participants from New Orleans, Louisiana. Differences in self-reported scores between baseline (January 2019-March 2020) and participant’s second survey (March 20, 2020, and onwards) were calculated. Logistic regression was employed to examine the association between social capital indicators and measures of psychological distress adjusting for key covariates and controlling for residential clustering effects. Participants who reported higher than average scores for social capital indicators were significantly less likely to report increases in psychosocial distress between pre and during the COVID-19 pandemic. Those who reported higher-than-average sense of community were approximately 1.2 times less likely than those who reported lower than average sense of community scores to experience increases in psychological distress before and during the global pandemic (OR = 0.79; 95% CI = 0.70,0.88, p ≤ 0.001), even after controlling for key covariates. Findings highlight the potentially important role that community social capital and related factors may play in the health of underrepresented populations during times of major stress. Specifically, the results suggest an important role of cognitive social capital and perceptions of community membership, belonging, and influence in buffering changes of mental health distress experienced during the initial period of the COVID-19 pandemic among a population that is majority Black and female.
Improving soil pH, nutrient concentrations, and enzyme activities by green manure returning in young and mature rubber plantation on Hainan Island, China
Authors: xu wenxian , Yang Qiu , Jiang Yamin , Yu Jianan , Li Jiale , Liu Wenjie , Wu Zhixiang 
Published: May 2023

Abstract

BackgroundStudying green manure decomposition in various returning methods can establish a scientific foundation for farmland nutrient management.MethodsIn a rubber plantation on Hainan Island, China, utilized the nylon mesh bag method to imitate the decomposition of kudzu (whole plant, stem, and leaf) under two returning methods (mulching and burying) in two different sites (young and mature rubber plantations). The decomposition rate and nutrient release dynamics of kudzu and investigated the impact of kudzu returning on various soil properties such as soil pH, soil organic carbon (SOC), total nitrogen (TN), total phosphorus (TP), nitrate nitrogen (NO3−-N), ammonium nitrogen (NH4+-N), available phosphorus (AP), and enzyme activities were analyzed.ResultsCompared with mulching, the burying returning method significantly increased the kudzu decomposition rate and nutrient release proportions. After 270 days, more than 80% of the C, N, and P in different components of kudzu were released. The decomposition rate was found to be more affected by the initial soil factors than by the endogenous nutrients of kudzu. Compared with CK, all kudzu treatments led to significant increases in soil enzyme activities and soil pH, SOC, NO3−-N, and AP concentrations in two rubber plantations. The TN and NH4+-N concentrations were significantly increased in mature rubber plantations, while the TP was the opposite.ConclusionThe kudzu returned can effectively alleviate soil acidic, improve soil nutrient availability, regulating soil enzyme activities of the rubber plantation in the short-term. These results provide a scientific basis for the rational application of kudzu in rubber plantations.