bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Plantago asiatica L. extract on the anagen phase in human hair follicle dermal papilla cells
Authors: Lee Jiyeon , Kim Nari , Jung Ah‐Reum , Jang Jun‐Hwan , Lee Jae‐Soeb , Bae Jun‐Tae 
Published: March 2023

AbstractBackgroundThe hair growth cycle consists of the anagen, catagen, and telogen phases, and hair follicle dermal papilla (HDP) cells of human hair play a role in the initiation and maintenance of the anagen phase. Reduction in HDP cells contributes to hair loss; however, the limited treatment options are associated with negative side effects. Therefore, a naturally derived substance with hair loss‐preventing properties is needed.AimWe investigated the hair growth‐stimulating activities of Plantago asiatica L. extract (PAE) and its molecular mechanism in HDP cells.MethodsCell proliferation was determined using a 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide solution. Relative mRNA and protein expression levels of hair growth factors were determined using quantitative real‐time polymerase chain reaction and western blotting, respectively. Additionally, a tube formation assay was performed in human umbilical vein endothelial cells (HUVEC).ResultsPlantago asiatica L. extract significantly increased the cell proliferation and expression of hair growth factors, including keratinocyte growth factor (KGF), vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2) and MYC, in HDP cells. Moreover, PAE led to the accumulation of β‐catenin by promoting the phosphorylation of glycogen synthase kinase‐3 beta (GSK‐3β) at Ser9 and cAMP response element‐binding protein (CREB) at Ser133 via phosphorylation of extracellular signal‐regulated kinase (ERK) (Thr202/Tyr204). PAE also increased tube formation in HUVECs, which promoted angiogenesis for the anagen phase.ConclusionsPlantago asiatica L. extract amplified tube formation and production of growth factors (KGF, VEGF) via the activation of GSK‐3β/β‐catenin and mitogen‐activated protein kinase (MAPK)/CREB signaling pathways, demonstrating its potential to safely promote hair growth by inducing the anagen phase.
Quality of life in mothers of children with psoriasis
Authors: Elgamal EmadEldin Abd Elmoneim , Aboelwafa Hany Othman , Ibrahim Ayman Ahmed Mahmoud , Elshafey Mai Esam Mohamed 
Published: March 2023

AbstractBackgroundPatients' and their mothers' quality of life is severely affected by childhood psoriasis. Almost all children have a chronic illness that lasts until adulthood, which puts them at risk for lifelong difficulties like stigma, psychiatric comorbidity, and suicide.ObjectiveEvaluation of the effects of childhood psoriasis on the mothers' quality of life was the project's primary objective.Subjects and Methods100 mothers of children with various kinds of psoriasis participated in the study. The Family Dermatology Life Quality Index (FDLQI) was used to evaluate the mothers' quality of life.ResultsThe mother's FDLQI score was between 3 and 25, with a mean of 13. In terms of how the FDLQI was interpreted, 8 moms had an incredibly enormous impact, 63 mothers had a very significant impact, 26 mothers had a moderate impact, and 3 mothers had a modest impact. We discovered a substantial direct link between the mother's FDLQI and the children's PASI scores. Furthermore, we discovered that scalp and pustular psoriasis had the highest FDLQI scores, indicating a poor quality of life.ConclusionBoth the quality of life for affected children and their cares may be negatively impacted by childhood psoriasis. Age of the children, PASI score, and kind of psoriasis can all have an impact on how psoriasis in childhood affects the mother.
Host specificity of flea parasites of mammals from the Andean Biogeographic Region
Authors: Sanchez Juliana P. , Berrizbeitia M. Fernanda López , Ezquiaga M. Cecilia 
Published: March 2023

AbstractHost specificity of fleas affects their biodiversity that plays a major role in determining the potential transmission routes by pathogens through vertebrate hosts, including humans. In the Biogeographic Andean region, numerous systematic and ecological studies have been conducted, revealing a high diversity of flea taxa of mammals and the presence of pathogenic organisms transmitted by fleas; however, the degree of preference with which each flea species associates with a mammal host remains poorly understood in this region. Herein, host specificity in mammal fleas from the Andean region was analysed. We employed the number of host species for each flea species and the index of host specificity STD*. Following the literature, 144 species and 13 subspecies of fleas (31 genera and 10 families) have been described in the Andean biogeographic region; 76 taxa are endemic to this region. To carry out the analyses of host specificity, we considered 1759 records of fleas collected from 124 species and 59 genera of wild and domestic mammals, mostly rodent species (85.9%). Our results indicate that typical Andean fleas are genus or family host specific (mostly STD* less than 3.0). More diverse mammal hosts are parasitized by more diverse flea genera and families and these hosts are phylogenetically related. Otherwise, these hosts are associated with different flea lineages, suggesting the interaction of ecological and evolutionary mechanisms (host‐switching, ecological adaptations and co‐evolutionary alternation). The fields of disease ecology and One Health are considering the host specificity of arthropod vectors as an important point to understand the mechanisms of emergence and re‐emergence of diseases. Our results allow us to estimate the risk of diseases involving fleas in the Andean region.
Protocol for a prospective cohort study exploring the gut microbiota of infants with congenital heart disease undergoing cardiopulmonary bypass (the GuMiBear study)
Authors: Magner Claire , Jenkins Dominic , Koc Fatma , Tan Mong Hoi , O’Toole Molly , Boyle Jordan , Maguire Niamh , Duignan Sophie , Murphy Kiera , Ross Paul , Stanton Catherine , McMahon Colin J 
Published: March 2023

IntroductionThe gut microbiota develops from birth and matures significantly during the first 24 months of life, playing a major role in infant health and development. The composition of the gut microbiota is influenced by several factors including mode of delivery, gestational age, feed type and treatment with antibiotics. Alterations in the pattern of gut microbiota development and composition can be associated with illness and compromised health outcomes.Infants diagnosed with ‘congenital heart disease’ (CHD) often require surgery involving cardiopulmonary bypass (CPB) early in life. The impact of this type of surgery on the integrity of the gut microbiome is poorly understood. In addition, these infants are at significant risk of developing the potentially devastating intestinal condition necrotising enterocolitis.Methods and analysisThis study will employ a prospective cohort study methodology to investigate the gut microbiota and urine metabolome of infants with CHD undergoing surgery involving CPB. Stool and urine samples, demographic and clinical data will be collected from eligible infants based at the National Centre for Paediatric Cardiac Surgery in Ireland. Shotgun metagenome sequencing will be performed on stool samples and urine metabolomic analysis will identify metabolic biomarkers. The impact of the underlying diagnosis, surgery involving CPB, and the influence of environmental factors will be explored. Data from healthy age-matched infants from the INFANTMET study will serve as a control for this study.Ethics and disseminationThis study has received full ethical approval from the Clinical Research Ethics Committee of Children’s Health Ireland, GEN/826/20.
Implementation of nursing-led follow-up service for patients newly discharged from paediatric intensive care units: quality improvement initiative
Authors: AlZaher Ruqiah Ali , Murabi Iris , Enazi Jaber , Antar Mohannad , Kolobe Efraim , Delafuente Shelia , Awani Mona 
Published: March 2023

BackgroundHuman resource shortages are a global challenge in the healthcare system and create barriers in providing timely follow-up visits for paediatric patients discharged recently from the intensive care unit (ICU). Relying on experienced intensive care nurses to provide follow-up services for patients post paediatric ICU (PICU) transfer has been proven a cost-effective and safe practice. This study aimed to achieve no delays in initiating follow-up visits and to assess the safety of implementing a nurse-led follow-up service.MethodsPlan–Do–Study–Act cycle was used targeting to achieve no delay in initiating follow-up visits and to maintain the safety of the patients. This cycle resulted in the implementation of a nurse-led follow-up service, which is under the provision of a paediatric rapid response team (RRT). Fifteen PICU nurses were trained in their new roles and responsibilities. Service databases were established to track and trend the frequency of visits, service safety measures and clinical deterioration.ResultsAfter the implementation of the nurse-led follow-up service, we achieved no delays in initiating the follow-up visits. 45% (n=487) of patients received a nurse-led follow-up visit service. Safety measures demonstrated 0.21% (n=1) recorded events of RRT activations during the follow-up service. RRT activation within 48 hours from service discharge was 1.2% (n=6), and readmission to PICU within 48 hours was 0.8% (n=4). No cardiopulmonary arrest event was recorded for patients under the nurse-led follow-up service during the service, postservice discharge or postreadmission to PICU.ConclusionsImplementing nursing-led service has been shown to be safe, efficient and provides patients with timely visits post-PICU discharge.
Gross myofascial release of trunk with leg pull technique on low back pain with radiculopathy — A randomised controlled trial
Authors: Rajan Abey P. , Gurudut Peeyoosha 
Published: March 2023

Background: Lower Back Pain (LBP) with radiculopathy is a potentially more serious form of mechanical low back pain. A paucity of literature exists about the effect of the gross myofascial release (MFR) technique on the management of LBP. Objective: The study aimed to evaluate the effect of gross MFR when given as an adjunct to conventional physical therapy in subjects with low back pain with radiculopathy. Methods: Forty subjects ([Formula: see text]) clinically diagnosed with LBP with radiculopathy were enrolled and randomly allocated to either the control group ([Formula: see text]) or the experimental group ([Formula: see text]). Both study groups received 5 sessions of intervention. The control group received conventional physical therapy while the experimental group received gross MFR of the trunk and lower limb along with conventional physical therapy. The outcome measures included were pressure pain threshold for the lower back and lower extremity, lumbar flexion and extension range of motion (ROM), percentage disability, and patient satisfaction towards the treatment which were measured pre-intervention (day 1) and post-treatment (day 5). The interaction between group and time was analysed using two-way mixed ANOVA. Results: The results suggested that the experimental group was statistically significant over the control group in terms of pressure pain threshold in the lower back ([Formula: see text]) and lower limb ([Formula: see text]), disability ([Formula: see text]), and patient satisfaction ([Formula: see text]) and lumbar flexion ([Formula: see text]) except lumbar extension ROM ([Formula: see text]). Conclusion: When given as an adjuvant to conventional physical therapy, gross myofascial release proved to provide a significant and faster short-term improvement over conventional treatment alone in subjects diagnosed with low back pain with radiculopathy.
Tratamento cirúrgico da espasticidade
Authors: Teixeira Manoel Jacobsen , Fonoff Erich Talammoni 
Published: March 2023

A espasticidade decorre de uma reorganização funcional de circuitos, em geral, medulares espinais após uma lesão que afeta total ou parcialmente as vias moduladoras damotricidade e controle das interações sensitivas. Agrava-se devido a estímulos nociceptivos ou sensitivos de outra natureza, aumento de citocinas e emoções. A Avaliação da espasticidade fundamenta-se nos dados de história e no exame físico ressaltando-se a ocorrência de fatoresdesencadeantes e agravantes e nas possíveis complicações de sua ocorrência. O tratamento fundamenta-se na remoção das possíveis causas da lesão neurológica e na eliminação defatores desencadeantes das crises de espasticidade, incluindo as escaras, os processos inflamatórios e dor. Os procedimentos de medicina física são importantes para a reabilitação, prevenção de complicações e melhora da função motora. Dentre os medicamentos miorrelaxantes destacando-se o baclofeno e o diazepam. Os procedimentos neurocirúrgicos funcionais ablativos, ou seja, as neurotomias super-seletivas, a rizotomia super-seletiva, a lesão do trato de Lissauer e do corno posterior da medula espinal e as mielotomias são indicadas em casos de ausência de melhora com procedimentos conservadores. A infusão de fármacos miorrelaxantes no compartimento liquórico é opção interessante especialmente no doente em que a atividade motora é útil.
The Pathway towards Triple Helix
Authors: Liche Mesay Barekew , Braun Střelcová Andrea 
Published: March 2023

Abstract
In 2015, the Ethiopian government established two Science and Technology (S&T) universities with the objective to boost university-industry collaboration. Although both Addis Ababa S&T University and Adama S&T University encourage such collaboration through their offices of technology transfer (OTT), their links with local industry are weak. However, current literature on triple helix in developing countries does not explain how universities can internally stimulate interaction with external actors. This paper addresses this gap by asking how the two universities evaluate the technology development process and how the current approach can be improved to stimulate triple helix interactions. Insights from organizational control theory (OCT) and the Context, Input, Process, and Product (CIPP) evaluation model are integrated into the triple helix framework in a qualitative case study design. Our findings indicate the existing approach combines outcome- and behavior-based evaluation, which constrains engagement with the industry. We recommend that a more comprehensive, people-based evaluation system, built around shared goals and involvement of industry as external stakeholders, is adopted as a pathway to triple helix.
Polycystic ovarian syndrome among women diagnosed with infertility in the Gulf Cooperation Council countries: A protocol for systematic review and meta-analysis of prevalence studies
Authors: Alam Zufishan , Abdalla Mohammed Altigani , Alseiari Saleh , Alameemi Mahra , Alzaabi Mayytha , Alkhoori Reem , Östlundh Linda , Al-Rifai Rami H. 
Published: March 2023

Background: Polycystic ovarian syndrome, a common endocrine disorder, is an important cause of infertility among women of reproductive age. Within the Gulf Cooperation Council countries, polycystic ovarian syndrome is found to affect women increasingly. No study has been carried out to critically summarize the evidence on the prevalence of polycystic ovarian syndrome among women suffering from infertility in these countries. Objective: This protocol aims to conduct a systematic review and meta-analysis of the studies reporting the prevalence of polycystic ovarian syndrome among women seeking infertility treatment in the six Gulf Cooperation Council countries (Bahrain, Kuwait, Oman, Saudi Arabia, Qatar, and United Arab Emirates). Design/Methods and analysis: The systematic review and meta-analysis will follow the following method. Data source: Five databases, including PubMed, Embase, CINAHL, Web of Science, and SCOPUS, will be searched for observational studies using a combination of relevant keywords and Medical Subject Headings from inception of databases. Data extraction: Two reviewers will screen titles and abstracts, followed by a full-text search based on the eligibility criteria. The main outcome is to measure the proportion of women who have polycystic ovarian syndrome among infertility-diagnosed patients. In addition, the risk of bias in the included studies will be assessed using the national institute of health quality assessment tool for observational studies. Data synthesis: The random-effects method of the analysis with the inverse variance will be used to calculate the pooled prevalence of polycystic ovarian syndrome–attributed infertility. Variation in prevalence estimates will be calculated using subgroup analysis based on study and patients’ characteristics and publication bias will be assessed via funnel plot inspection and Eggar’s test. Discussion: A critical assessment of evidence on the prevalence of polycystic ovarian syndrome in women attending fertility clinics is helpful in risk quantification, enabling better planning for managing infertility in women with polycystic ovarian syndrome. Registration: This protocol has been registered with PROSPERO, protocol registration number (CRD42022355087).
Application of behavioral change theory and models on COVID-19 preventive behaviors, worldwide: A systematic review
Authors: Anagaw Tadele Fentabil , Tiruneh Misganaw Guadie , Fenta Eneyew Talie 
Published: March 2023

Objective: This systematic review aimed to assess the global application of behavioral change theory and models on COVID-19 preventive behaviors. Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses procedure. Databases such as PubMed/MIDLINE, Web of Science, Scopus, EMB ASE, World Health Organization libraries, and Google Scholar were used to search all published articles in the area of application of behavioral change theory and model on COVID-19 preventive behavior until October 1, 2022. Studies published in another language other than English were excluded. Two independent reviewers did the article selection and quality check. A third reviewer asked if any disagreement were found. Result: Seventeen thousand four hundred thirty-six total articles were retrieved from all sources after the removal of duplicated articles and those not evaluating the outcome of interest were excluded. Finally, 82 articles done using behavioral change theory and model on COVID-19 preventive behaviors were included. The health belief model (HBM) and theory of planned behavior (TPB) were most commonly used in COVID-19 preventive behaviors. The constructs of most behavioral theories and models were significantly associated with COVID-19 preventive behaviors such as hand washing, face mask use, vaccine uptake, social isolation, self-quarantine, social distance, and use of sanitizers. Conclusion: This systematic review summarizes comprehensive evidence on the application of behavioral change theory and model on COVID-19 preventive behaviors globally. A total of seven behavioral change theories and models were included. The HBM and TPBs were most commonly used for COVID-19 preventive behaviors. Therefore, the application of behavioral change theory and models is recommended for developing behavioral change interventional strategies.
Feasibility and acceptability of an online guided self-determination program to improve diabetes self-management in young adults
Authors: Rasmussen Bodil , Wynter Karen , Hamblin Peter S , Rodda Christine , Steele Cheryl , Holton Sara , Zoffmann Vibeke , Currey Judy 
Published: March 2023

Objective Evaluate the feasibility and acceptability of an online guided self-determination (GSD) program to improve diabetes self-management skills among young adults with type 1 diabetes (YAD). Methods An online program comprising seven structured interactive conversations was designed. A pre- and post- interventional study used a sequential, two-phase multiple method design. Phase one comprised a training program for diabetes educators (DEs). In Phase two YAD participated in program and completed pre- and post-surveys assessing motivation to self-manage, perceived competence in diabetes and communication with DEs. Both YAD and DEs provided a program evaluation. Results The online GSD program was acceptable, feasible and effective in improving autonomous motivation in self-management and communication with DEs. Easy access and program flexibility were highly appreciated by both participant groups and perceived to assist YAD to stay motivated. Conclusion The program had a significant impact on the diabetes self-management of YAD and was a feasible and acceptable way to engage and communicate with DEs. The GSD platform contributes to age appropriate and person-centred diabetes self-management. It can potentially reach geographically distanced populations, or with social circumstances or other barriers impeding in-person service provision.
Intravoxel Incoherent Motion Factors Affecting Collapse and Nonunion of Osteoporotic Vertebral Fracture
Authors: Ogon Izaya , Takebayashi Tsuneo , Takashima Hiroyuki , Abe Yasuhisa , Oguma Hiroshi , Imamura Rui , Akatsuka Yoshihiro , Morita Tomonori , Teramoto Atsushi 
Published: March 2023

Study Design Longitudinal study. Objectives Intravoxel incoherent motion (IVIM), a magnetic resonance imaging (MRI) scanning technique that applies diffusion-weighted imaging (DWI), is effective for the quantitative assessment of malignant tumors of the vertebral bone. We hypothesized that IVIM parameters of vertebral bodies are associated with the prognosis of osteoporotic vertebral fracture (OVF). We aimed to explore the relationships between IVIM parameters for vertebral collapse and non-union after OVF and calculate the cut-off values of these parameters for vertebral collapse and non-union. Methods A total of 150 patients with acute OVF (150 women; mean age: 79.1 ± 7.4 years) were included and treated conservatively with bracing. MRI was performed at the time of injury. IVIM parameters, such as apparent diffusion coefficient (ADC), molecular diffusion coefficient (D), and perfusion-related diffusion (D*) were recorded. The patients were classified into 3 groups: low-collapse (height loss of ≤50%), high-collapse (height loss of >50%), and non-union. We compared ADC, D, and D* among the low-collapse, high-collapse, and non-union groups and performed a receiver operating characteristic (ROC) curve analysis to determine the boundary values of the high-collapse and non-union groups. Results The low-collapse, high-collapse, and non-union groups had no significant differences in ADC and D. However, D* differed significantly among the 3 groups. ROC analysis revealed cut-off values of 19.0 × 10-3 mm2/s and 12.3 × 10-3 mm2/s for the high-collapse and non-union groups, respectively. Conclusions D* is a significant prognostic indicator for high-collapse and non-union groups with OVF. This suggests that D* should be considered when assessing OVF.