bluuebunny/crossref_metadata_2025_split huggingface dataset:
The field of human building interaction for convergent research and innovation for intelligent built environments
Authors: Becerik-Gerber Burcin , Lucas Gale , Aryal Ashrant , Awada Mohamad , Bergés Mario , Billington Sarah , Boric-Lubecke Olga , Ghahramani Ali , Heydarian Arsalan , Höelscher Christoph , Jazizadeh Farrokh , Khan Azam , Langevin Jared , Liu Ruying , Marks Frederick , Mauriello Matthew Louis , Murnane Elizabeth , Noh Haeyoung , Pritoni Marco , Roll Shawn , Schaumann Davide , Seyedrezaei Mirmahdi , Taylor John E. , Zhao Jie , Zhu Runhe 
Published: December 2022

AbstractHuman-Building Interaction (HBI) is a convergent field that represents the growing complexities of the dynamic interplay between human experience and intelligence within built environments. This paper provides core definitions, research dimensions, and an overall vision for the future of HBI as developed through consensus among 25 interdisciplinary experts in a series of facilitated workshops. Three primary areas contribute to and require attention in HBI research: humans (human experiences, performance, and well-being), buildings (building design and operations), and technologies (sensing, inference, and awareness). Three critical interdisciplinary research domains intersect these areas: control systems and decision making, trust and collaboration, and modeling and simulation. Finally, at the core, it is vital for HBI research to center on and support equity, privacy, and sustainability. Compelling research questions are posed for each primary area, research domain, and core principle. State-of-the-art methods used in HBI studies are discussed, and examples of original research are offered to illustrate opportunities for the advancement of HBI research.
Tai chi-muscle power training for children with developmental coordination disorder: a randomized controlled trial
Authors: Fong Shirley S. M. , Chung Louisa M. Y. , Schooling Catherine Mary , Lau Eric H. Y. , Wong Janet Y. H. , Bae Young-Hyeon , Chung Joanne W. Y. 
Published: December 2022

AbstractThis study compared the effectiveness of tai chi (TC) muscle power training (MPT), TC alone, MPT alone, and no training for improving the limits of stability (LOS) and motor and leg muscular performance and decreasing falls in children with developmental coordination disorder (DCD). One hundred and twenty-one children with DCD were randomly assigned to the TC-MPT, TC, MPT, or control group. The three intervention groups received TC-MPT, TC, or MPT three times per week for 3 months. Measurements were taken before and after the intervention period. The primary outcomes were the LOS completion time and dynamic LOS scores. The secondary outcomes included the Movement Assessment Battery for Children-Second Edition total test score and percentile rank, knee muscle peak force and time to peak force, and the number of falls. None of the interventions affected the LOS test scores. Improvements in the peak forces of the knee extensors and flexors were demonstrated in the TC (p = 0.006) and MPT groups (p = 0.032), respectively. The number of falls also decreased in these two groups (p < 0.001). Thus, clinicians may prescribe TC or MPT for children with DCD to increase their knee muscle strength and reduce their risk of falls.
A matched-filter technique with an objective threshold
Authors: Hirano Shiro , Kawakata Hironori , Doi Issei 
Published: December 2022

AbstractWe propose an objective threshold determination method for detecting outliers from the empirical distribution of cross-correlation coefficients among seismic waveforms. This method is aimed at detecting seismic signals from continuous waveform records. In our framework, detectability is automatically determined from Akaike’s Information Criterion (AIC). We applied the method of seismic signal detection to continuous records collected over two years. The results show that the maximum value of network cross-correlation coefficients sampled from each constant interval can be approximated by the theory of extreme value statistics, which provides a parametric probability density function of maxima. By using the function, outliers can be considered with a reasonable criterion.
Multidimensional tie strength and economic development
Authors: Aiello Luca Maria , Joglekar Sagar , Quercia Daniele 
Published: December 2022

AbstractThe strength of social relations has been shown to affect an individual’s access to opportunities. To date, however, the correspondence between tie strength and population’s economic prospects has not been quantified, largely because of the inability to operationalise strength based on Granovetter’s classic theory. Our work departed from the premise that tie strength is a unidimensional construct (typically operationalized with frequency or volume of contact), and used instead a validated model of ten fundamental dimensions of social relationships grounded in the literature of social psychology. We built state-of-the-art NLP tools to infer the presence of these dimensions from textual communication, and analyzed a large conversation network of 630K geo-referenced Reddit users across the entire US connected by 12.8M social ties created over the span of 7 years. We found that unidimensional tie strength is only weakly correlated with economic opportunities ($$R^2=0.30$$

R
2

=
0.30

), while multidimensional constructs are highly correlated ($$R^2=0.62$$

R
2

=
0.62

). In particular, economic opportunities are associated to the combination of: (i) knowledge ties, which bridge geographically distant groups, facilitating the knowledge dissemination across communities; and (ii) social support ties, which knit geographically close communities together, and represent dependable sources of social and emotional support. These results point to the importance of developing high-quality measures of tie strength in network theory.
Activation of basal forebrain-to-lateral habenula circuitry drives reflexive aversion and suppresses feeding behavior
Authors: Swanson Jessica L. , Ortiz-Guzman Joshua , Srivastava Snigdha , Chin Pey-Shyuan , Dooling Sean W. , Hanson Moss Elizabeth , Kochukov Mikhail Y. , Hunt Patrick J. , Patel Jay M. , Pekarek Brandon T. , Tong Qingchun , Arenkiel Benjamin R. 
Published: December 2022

AbstractEnvironmental cues and internal states such as mood, reward, or aversion directly influence feeding behaviors beyond homeostatic necessity. The hypothalamus has been extensively investigated for its role in homeostatic feeding. However, many of the neural circuits that drive more complex, non-homeostatic feeding that integrate valence and sensory cues (such as taste and smell) remain unknown. Here, we describe a basal forebrain (BF)-to-lateral habenula (LHb) circuit that directly modulates non-homeostatic feeding behavior. Using viral-mediated circuit mapping, we identified a population of glutamatergic neurons within the BF that project to the LHb, which responds to diverse sensory cues, including aversive and food-related odors. Optogenetic activation of BF-to-LHb circuitry drives robust, reflexive-like aversion. Furthermore, activation of this circuitry suppresses the drive to eat in a fasted state. Together, these data reveal a role of basal forebrain glutamatergic neurons in modulating LHb-associated aversion and feeding behaviors by sensing environmental cues.
Validation of the brief instrument “Health Literacy for School-Aged Children” (HLSAC) among Norwegian adolescents
Authors: Bjørnsen Hanne Nissen , Moksnes Unni Karin , Eilertsen Mary-Elizabeth B. , Espnes Geir Arild , Haugan Gørill 
Published: December 2022

AbstractHealth literacy (HL) has been identified as an important and modifiable determinant of health. To succeed in promoting HL, it is crucial to evaluate interventions addressing HL using validated instruments. However, HL measurement is an under-researched area among adolescents. The Health Literacy for School-Aged Children (HLSAC) scale is developed in Finland to measure the subjective HL levels of school-aged children. The HLSAC has been used and validated across Europe. No validated instrument for measuring HL among Norwegian adolescents has been identified. Therefore, the aim of this study was to assess the psychometric properties of the HLSAC among Norwegian adolescents in upper secondary schools. Cross-sectional data were collected in 2017 from 1 054 adolescents with a response rate of 93.5%. The participants were students aged 16–21 (mean = 17.3) years from four upper secondary schools in an urban area in Mid-Norway. Confirmatory factor analysis (CFA) was utilized to investigate the underlying dimensionality of the data together with composite reliability based on Raykov’s reliability coefficient and certain aspects of construct validity. The original ten-item one-dimensional version of the HLSAC revealed a poor fit. A one-dimensional version including six of the original ten items presented the best fit to our data, demonstrating good reliability and construct validity. This validation study suggests a one-dimensional solution of the HLSAC scale including six of the original ten items, i.e., the HLSAC-6 as a statistical valid and reliable measure for HL among adolescents in upper secondary schools. However, the modifications of the instrument indicate the need for further investigation of the HLSAC in this age group, i.e. by conducting cognitive interviews and focus-group discussions on the concept of HL among adolescents. Testing the wording of the HLSAC prior to additional psychometric evaluations of both the original HLSAC and the suggested HLSAC-6 is recommended. Finally, developing more age-appropriate items for the measurement of HL in this age-group is suggested.
Preparation, characterization and properties of three different nanomaterials either alone or loaded with nystatin or fluconazole antifungals
Authors: Helal Sara H. , Abdel-Aziz Heba M. M. , El-Zayat Mustafa M. , Hasaneen Mohammed N. A. 
Published: December 2022

AbstractEngineered nanoparticles have enabled the development of novel uses, particularly in disease management. In this investigation, we synthesized and studied three distinct nanomaterials: solid lipid nanoparticles (SLNPs), chitosan nanoparticles (CSNPs), and carbon nanotubes (CNTs), either alone or loaded with two antifungals, nystatin, and fluconazole. The purpose of this study is to investigate the different properties of the produced nanomaterials, either alone or in combination with antifungals. Drug release studies revealed that about 55% from SLNPs, 43% from CSNPs and 97% from CNTs of nystatin drug were released at the longest time point assessed (12 h). In addition, about 89% from SLNPs, 84% from CSNPs and 81% from CNTs of fluconazole drug were released at the longest time point assessed (12 h). This research will expand the understanding of nanomaterials as a viable technique for the management of different fungal diseases that harm several agricultural crops.
Efficient modification and preparation of circular DNA for expression in cell culture
Authors: Oliynyk Roman Teo , Church George M. 
Published: December 2022

Abstract
DNA plasmids are an essential tool for delivery and expression of RNAs and proteins in cell culture experiments. The preparation of plasmids typically involves a laborious process of bacterial cloning, validation, and purification. While the expression plasmids can be designed and ordered from the contract manufacturers, the cost may be prohibitive when a large number of plasmids is required. We have developed an efficient fully synthetic method and protocol that enables the production of circularized DNA containing expression elements ready for transfection in as little as 3 hours, thereby eliminating the bacterial cloning steps. The protocol describes how to take a linear double-stranded DNA fragment and efficiently circularize and purify this DNA fragment with minimal hands-on time. As proof of the principle, we applied Circular Vector expressing engineered prime editing guide RNA (epegRNA) in cell culture, and demonstrated matching and even exceeding performance of this method as compared to guides expressed by plasmids. The method’s speed of preparation, low cost, and ease of use will make it a useful tool in applications requiring the expression of short RNAs and proteins.
Star formation in outer rings of S0 galaxies
Authors: Sil’chenko O. , Moiseev A. , Oparin D. , Beckman J. E. , Font J. 
Published: December 2022

Aims. Though S0 galaxies are usually thought to be ‘red and dead’, they often demonstrate weak star formation organised in ring structures and located in their outer disks. We try to clarify the nature of this phenomenon and its difference from star formation in spiral galaxies. The nearby moderate-luminosity S0 galaxy UGC 4599 is studied here.
Methods. By applying long-slit spectroscopy at the Russian 6 m telescope, we have measured stellar kinematics for the main body of the galaxy and strong emission-line flux ratios in the ring. After inspecting the gas excitation in the ring using line ratio diagrams, and having shown that it is ionised by young stars, we determined the gas oxygen abundance by using conventional strong-line calibration methods. We inspected the gas kinematics in the ring with Fabry–Perot interferometer data obtained at the William Herschel Telescope. The pattern and properties of the brightest star formation regions were studied with the tunable filter MaNGaL at the 2.5 m telescope of the Caucasian Mountain Observatory of the SAI MSU.
Results. The gas metallicity in the ring is certainly subsolar, [O/H] = −0.4 ± 0.1 dex, which is different from the majority of the outer star-forming rings in S0s we have studied in the past, which typically have nearly solar metallicity. The total stellar component of the galaxy, which is old in the centre, is less massive than its extended gaseous disk. We conclude that the ring and the outer disk of UGC 4599 are probably a result of gas accretion from a cosmological filament.
Zungengrundhyperplasie nach Tonsillektomie und Korrelation mit dem BMI
Authors: Roßberg Willi , Dagistani Ahmad , Mitovska Dragana , Krüger Caroline , Warnecke Athanasia , Lenarz Thomas , Durisin Martin 
Published: December 2022

Zusammenfassung
Hintergrund Die Hyperplasie der Zungengrundtonsille ist eine seltene und zugleich auch potenziell gefährliche Veränderung im Bereich der oberen Atemwege. Die Pathogenese der Zungengrundhyperplasie (ZGH) ist immer noch weitgehend unbekannt. Im Rahmen dieser Studie wurde der Zusammenhang zwischen Zustand nach Tonsillektomie und kompensatorischer Zungengrundhyperplasie untersucht.
Material und Methoden In der HNO-Klinik der Medizinischen Hochschule Hannover wurden 300 Patienten konsekutiv untersucht. Im Rahmen der indirekten Laryngoskopie wurden die Zungengrundtonsille, Einsehbarkeit des Larynx sowie seiner Subregionen nach einem Schema beurteilt. Die Daten wurden anschließend in Abhängigkeit vom Status der Gaumentonsillen ausgewertet. Ergänzend wurde der Body-Mass-Index (BMI) ermittelt und mit Ergebnissen der Laryngoskopie verglichen.
Ergebnisse Von den 300 untersuchten Patienten war bei 89 (29,6%) eine Tonsillektomie beidseits durchgeführt worden. In der Gesamtpopulation war eine stark vergrößerte Zungengrundtonsille nur in 14 Fällen (4,6%) nachweisbar. Von diesen 14 wurde bei 4 Patienten in der Vorgeschichte eine Tonsillektomie durchgeführt. Der BMI zeigte bei Patienten mit einer normal großen Zungengrundtonsille einen Wert von 24,4 und bei Patienten mit starker Zungengrundhyperplasie 27,3.
Schlussfolgerungen Die Inzidenz der ZGH fällt nach unseren Ergebnissen mit 4,7 % gering aus. Ein Zusammenhang zwischen einem Zustand nach Tonsillektomie und kompensatorischer Zungengrundhyperplasie konnte nicht nachgewiesen werden. Es zeigte sich jedoch ein statistisch signifikanter Zusammenhang zwischen BMI und ZGH.
Cannabis in der Onkologie – viel Rauch um nichts?
Authors: Burkhard-Meier Anton , Rémi Constanze , Lindner Lars H. , von Bergwelt-Baildon Michael 
Published: December 2022

ZusammenfassungDie medizinische Verwendung von Cannabis hat in den letzten Jahren in Europa und Nordamerika an Popularität gewonnen. Cannabinoide sind sowohl als Fertigarzneimittel als auch in Blüten- und Extraktform verfügbar. Der vorliegende Artikel legt den Fokus auf die supportive Therapie onkologischer Patienten. Mögliche Indikationen sind Schmerzen, Chemotherapie-bedingte Übelkeit und Erbrechen, Appetitlosigkeit und Geschmacksveränderungen. Trotz des enormen Hypes um Cannabis als Medizin ist die Evidenz für dessen Anwendung bei onkologischen Patienten unzureichend. Palliativpatienten mit refraktären Symptomen könnten jedoch geeignete Kandidaten für einen Therapieversuch darstellen. Der entscheidende Parameter für die Auswahl eines Cannabis-Arzneimittels ist die THC/CBD-Ratio. Orale Einnahmeformen bieten sich gerade für Cannabis-naive und ältere Patienten an. Psychische und kardiovaskuläre Nebenwirkungen sind nicht zu unterschätzen.
The Triple Aim Quality Improvement Gold Standard Illustrated as Extremely Premature Infant Care
Authors: Kaempf Joseph W. , Wang Lian , Dunn Michael 
Published: December 2022

Objectives The Triple Aim is widely regarded as the quality improvement gold standard that enhances population health, lowers costs, and betters individual care. There have been no large-scale, sustained demonstrations of such improvement in healthcare. Illustrating the Triple Aim using relevant extremely premature infant outcomes might highlight interwoven proficiency and efficiency complexities that impede sustained value progress.
Study Design Ten long-term collaborating neonatal intensive care units (NICU) in the Vermont Oxford Network calculated the Triple Aim in 230/7 to 276/7-week infants using three surrogate measures: (1) population health/x-axis—eight major morbidity rates as a composite, risk-adjusted metric; (2) cost/y-axis—total hospital length of stay; and (3) individual care/z-axis—mortality, then illustrated this relationship as a sphere within a three-dimensional cube.
Results Three thousand seven hundred six infants born between January 1, 2014 and December 31, 2019, with mean (standard deviation) gestational age of 25.7 (1.4) weeks and birth weight of 803 (208) grams were analyzed. Triple Aim three-axis cube positions varied inconsistently comparing NICUs. Each NICUs' sphere illustrated mixed x- and z-axis movement (clinical proficiency), and y-axis movement (cost efficiency). No NICU demonstrated the theoretically ideal Triple Aim improvement in all three axes. Backward movement in at least one axis occurred in eight NICUs. The whole-group Triple Aim sphere moved forward along the x-axis (better morbidities metric), but moved backward in the y-axis length of stay and z-axis mortality measurements.
Conclusion Illustrating the Triple Aim gold standard as extreme prematurity outcomes reveals complexities inherent to simultaneous attempts at improving interwoven quality and cost outcomes. Lack of progress using relevant Triple Aim parameters from our well-established collaboration highlights the difficulties prioritizing competing outcomes, variable potentially-better-practice applications amongst NICUs, unmeasured biologic interactions, and obscured cultural–environmental contexts that all likely affect care. Triple Aim excellence, if even remotely possible, will necessitate scalable, evidence-based methodologies, pragmatism regarding inevitable trade-offs, and wise constrained-resource decisions.
Key Points
Gallstone Ileus—Lessons from a Missed Diagnosis
Authors: Sathe Animesh Ajit , Bhargava Rajat Naresh 
Published: December 2022

AbstractGallstone ileus is an uncommon presentation in patients with acute abdomen. Its diagnosis and treatment are often delayed due to its nonspecific clinical presentation. Presence of gallstone in ileum can be difficult to detect on computed tomography (CT) as mostly they are lucent. We report the case of a 66-year-old man with a 1-day history of vomiting and abdominal bloating. Initial CT could not identify the obstructing gall stone. On the follow-up CT, there was a distal shift of obstruction site in the intestine raising suspicion of a gallstone. We discuss the imaging findings on CT and the clues to diagnosing gallstone ileus.
Antioxidant and Anti-Anemic Effects of Ethanol Leaf Extracts of Mucuna poggei and Telfairia occidentalis in Phenyl-Hydrazine-Induced Anemia in Wistar Albino Rats
Authors: Udeozor Precious A. , Ibiam Udu A. , Uti Daniel E. , Umoru Grace U. , Onwe Eucharia N. , Mbonu Francis O. , Omang Wilson A. , Ijoganu Samuel I. , Anaga Charles O. , Mbah Jenavine Onyinye , Nwadum Solomon K. 
Published: December 2022

Abstract
Introduction With the use of recent therapeutic data, several methods for finding medications from untapped natural materials continue to advance research and development. The antioxidant and antianemic effects of ethanol leaf extracts of Telfairia occidentalis and Mucuna poggei in phenylhydrazine-induced anemia in Wister albino rats were investigated.
Method A total of 54 male albino rats were randomly assigned to nine experimental groups (n = 6). Anemia was induced in groups 2 to 9 with 10 mg/kg body weight of phenylhydrazine. Group 1 (normal control) rats were administered normal saline only. Group 2 (anemic control) rats were untreated. Group 3 (standard controls) rats were treated with a standard multivitamin, groups 4, 5, and 6 rats were treated with varying doses of M. poggei leaf extract respectively, while groups 7, 8, and 9 rats were treated with similar doses of T. occidentalis leaf extract by oral intubation for 21 days.
Results Earlier, the gas chromatography-mass spectrometry analysis indicated eighteen (18) and twenty-nine (29) active compounds present in M. poggei and T. occidentalis, respectively. More so, T. occidentalis and M. poggei were studied for their inhibitory potentials against 2,2-diphenyl-1 picrylhydrazyl-free radicals, nitric oxide, phosphomolybdenum, and ferric-reducing antioxidant power. M. poggei and T. occidentalis also showed the following trend of minerals Mg > Ca > Fe > Na > Zn > Mn > K and Mg > Fe > Ca > Na > K > Mn > Zn, respectively. The results also showed that the packed cell volume, red blood cells, and hemoglobin significantly (p < 0.05) decreased in anemic control rats compared with normal controls and were significantly (p < 0.05) increased on treatment with the leaf extracts. Catalase, superoxide dismutase, glutathione peroxidase activities, and glutathione levels significantly (p < 0.05) decreased in anemic control, compared with normal. However, these significantly (p < 0.05) increased on treatment with the leaf extracts in a dose-independent manner. Malondialdehyde levels took the reverse trend.
Conclusion This study indicated that leaf extracts of M. poggei and T. occidentalis can be used in the management of anemia and oxidative stress-related complications