bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the volume of vascular intersection of two femoral neck fracture fixation implants using an In silico technique
Authors: Putnam Matthew D. , Rau Andrew , Frohbergh Michael , Ong Kevin , Bushelow Michael , Blauth Michael 
Published: May 2023

Background:
Femoral neck fracture displacement with subsequent vascular disruption is one of the factors that contribute to trauma-induced avascular necrosis of the femoral head. Iatrogenic damage of the intraosseous arterial system during fixation of femoral neck fracture is another possible cause of avascular necrosis that is less well understood. Recently, Zhao et al (2017) reconstructed 3D structures of intraosseous blood supply and identified the epiphyseal and inferior retinacular arterial system to be important structures for maintaining the femoral head blood supply after femoral neck fracture. The authors therefore recommended placing implants centrally to reduce iatrogenic vascular injuries. Our in vitro study compared the spatial footprint of a traditional dynamic hip screw with an antirotation screw versus a newly developed hip screw with an integrated antirotation screw on intraosseous vasculature.

Methods:
Three dimensional (3D) µCT angiograms of 9 cadaveric proximal femora were produced. Three segmented volumes—porous or cancellous bone, filled or cortical bone, and intraosseous vasculature—were converted to surface files. 3D in silico models of the fixation systems were sized and implanted in silico without visibility of the vascular maps. The volume of vasculature that overlapped with the devices was determined. The ratio of the vascular intersection to the comparator device was calculated, and the mean ratio was determined. A paired design, noninferiority test was used to compare the devices.

Results:
Results indicate both significant (P < 0.001) superiority and noninferiority of the hip screw with an integrated antirotation screw when compared with a dynamic hip screw and antirotation screw for the volume of vasculature that overlapped with each device in the femoral neck.

Conclusions:
Combining established methods of vascular visualization with newer methods enables an implant's impact on vascular intersection to be assessed in silico. This methodology suggests that when used for femoral neck fracture management, the new device intersects fewer blood vessels than the comparator. Comparative clinical studies are needed to investigate whether these findings correlate with the incidence of avascular necrosis and clinical outcomes.
Long-distance Wnt transport in axons highlights cell type-specific modes of Wnt transportin vivo
Authors: Pani Ariel M , Favichia Michelle , Goldstein Bob 
Published: May 2023

AbstractWnt signaling performs critical functions in development, homeostasis, and disease states. Wnt ligands are secreted signaling proteins that often move between cells to activate signaling across a range of distances and concentrations. In different animals and developmental contexts, Wnts utilize distinct mechanisms for intercellular transport including diffusion, cytonemes and exosomes [1]. Mechanisms for intercellular Wnt dispersal remain controversial in part due to technical challenges with visualizing endogenous Wnt proteinsin vivo, which has limited our understanding of Wnt transport dynamics. As a result, the cell-biological bases for long-range Wnt dispersal remain unknown in most instances, and the extent to which differences in Wnt transport mechanisms vary by cell type, organism, and/or ligand remain uncertain. To investigate processes underlying long-range Wnt transportin vivo, we utilizedC. elegansas an experimentally tractable model where it is possible to tag endogenous Wnts with fluorescent proteins without disrupting signaling [2]. Live imaging of two endogenously tagged Wnt homologs revealed a novel mode for long-distance Wnt movement in axon-like structures that may complement Wnt gradients generated by diffusion and highlighted cell type-specific Wnt transport processesin vivo.
Conditional independence as a statistical assessment of evidence integration processes
Authors: Salinas Emilio , Stanford Terrence R 
Published: May 2023

AbstractIntuitively, combining multiple sources of evidence should lead to more accurate decisions than considering single sources of evidence individually. In practice, however, the proper computation may be difficult, or may require additional data that are inaccessible. Here, based on the concept of conditional independence, we consider expressions that can serve either as recipes for integrating evidence based on limited data, or as statistical benchmarks for characterizing evidence integration processes. Consider three events,A, B, andC. We find that, ifAandBare conditionally independent with respect toC, then the probability thatCoccurs given that bothAandBare known,P(C|A, B), can be easily calculated without the need to measure the full three-way dependency betweenA, B, andC. This simplified approach can be used in two general ways: to generate predictions by combining multiple (conditionally independent) sources of evidence, or to test whether separate sources of evidence are functionally independent of each other. These applications are demonstrated with four computer-simulated examples, which include detecting a disease based on repeated diagnostic testing, inferring biological age based on multiple biomarkers of aging, discriminating two spatial locations based on multiple cue stimuli (multisensory integration), and examining how behavioral performance in a visual search task depends on selection histories. Besides providing a sound prescription for predicting outcomes, this methodology may be useful for analyzing experimental data of many types.
Mission drift or mission fulfillment? Examining microfinance's financial and social performance with growth curve modeling and variance decomposition
Authors: Jia Peiyi , Sun Sunny Li 
Published: May 2023

PurposeExamining multilevel effects of financial and social performance of microfinance institutions (MFIs), the authors aim to investigate microfinance mission drift from the trend effect. The authors also seek to move the literature forward by decomposing the performance variance at different levels and examining whether and how much each level of analysis matters.Design/methodology/approachGrowth curve modeling and variance decomposition analysis were conducted using a dataset consisting of 17,953 observations of 2,902 microfinance institutions in 122 countries from 1999 to 2017.FindingsThe study's result shows no evidence of mission drift in the microfinance industry. While MFIs improve their economic returns, they also increase the depth of outreach. In addition, firm-level heterogeneity is the dominant effect which explains 44% of the variance in microfinance financial performance (ROA) and 39% of the variance in social performance (Depth of outreach). The country-level is more critical in explaining financial performance (ROA) than social performance (Depth of outreach), accounting for 11 and 32% of the total variance, respectively. In particular, the interplay between the country-level and organizational-category level accounts for 9 and 11% of the total variance in financial performance (ROA) and social performance (Depth of outreach), respectively.Originality/valueThis study’s multilevel analysis of microfinance performances moves the literature forward by responding to the debate on microfinance mission drift and providing a comprehensive overview of both social and financial performance. By focusing on the trend effect, the result of our models shows that MFIs improve both financial and social performance to fulfill dual missions. The microfinance business model becomes sustainable over time. The study's results of country effect and its interaction effect with different organizational categories reveal the prominence of a good policy design on MFI's mission fulfillment.
Reminiscence and wellbeing – reflecting on past festival experiences during Covid lockdowns
Authors: Wood Emma Harriet , Kinnunen Maarit 
Published: May 2023

PurposeTo explore the value in reminiscing about past festivals as a potential way of improving wellbeing in socially isolated times.Design/methodology/approachThe paper uses previous research on reminiscence, nostalgia and wellbeing to underpin the analysis of self-recorded memory narratives. These were gathered from 13 pairs of festivalgoers during Covid-19 restrictions and included gathering their individual memories and their reminiscences together. The participant pairs were a mix of friends, family and couples who had visited festivals in the UK, Finland and Denmark.FindingsFour key areas that emerged through the analysis were the emotions of nostalgia and anticipation, and the processes of reliving emotions and bonding through memories.Research limitations/implicationsFuture studies could take a longitudinal approach to see how memory sharing evolves and the impact of this on wellbeing. The authors also recommend undertaking similar studies in other cultural settings.Practical implicationsThis study findings have implications for both post-festival marketing and for the further development of reminiscence therapy interventions.Originality/valueThe method provides a window into memory sharing that has been little used in previous studies. The narratives confirm the value in sharing memories and the positive impact this has on wellbeing. They also illustrate that this happens through positive forms of nostalgia that centre on gratitude and lead to hope and optimism. Anticipation, not emphasised in other studies, was also found to be important in wellbeing and was triggered through looking back at happier times.
How frequent and visible criminal violence affects housing prices: evidence from Mexico City (2007–2011)
Authors: Atuesta Laura H. , Carrasco Monserrat 
Published: May 2023

Purpose
Between 2006 and 2012, Mexico implemented a “frontal war against organized crime”. This strategy increased criminal violence and triggered negative consequences across the country’s economic, political and social spheres. This study aims to analyse how the magnitude and visibility of criminal violence impact the housing market of Mexico City.

Design/methodology/approach
The authors used different violent proxies to measure the effect of the magnitude and visibility of violence in housing prices. The structure of the data set is an unbalanced panel with no conditions of strict exogeneity. To address endogeneity, the authors calculate the first differences to estimate an Arellano–Bond estimator and use the lags of the dependent variable to instrumentalise the endogenous variable.

Findings
Results suggest that the magnitude of violence negatively impacts housing prices. Similarly, housing prices are negatively affected the closer the property is to visible violence, measured through narcomessages placed next to the bodies of executed victims. Lastly, housing prices are not always affected when a violent event occurs nearby, specifically, when neighbours or potential buyers consider this event as sporadic violence.

Originality/value
There are only a few studies of violence in housing prices using data from developing countries, and most of these studies are conducted with aggregated data at the municipality or state level. The authors are using geocoded information, both violence events and housing prices, to estimate more disaggregated effects. Moreover, the authors used different proxies to measure different characteristics of violence (magnitude and visibility) to estimate the heterogeneous effects of violence on housing prices.
Variation of surface integrity of cylindrical rollers under grinding and superfinishing processes
Authors: Wang Zhijian , Wang Yin , Liu Lin , Zhu Wengsheng , Li Jing , Zhao Yujie , Pang Haijun , Wu Qilong 
Published: May 2023

Purpose
The aim of this study is to first investigate the surface integrity of cylindrical rollers under grinding process and then design a reasonable superfinishing process that improve the anti-fatigue performance of cylindrical rollers by optimization of the surface integrity.

Design/methodology/approach
First, the white and dark layers produced by the grinding process is analyzed by microscope. Then, the influence of oilstone pressure on the stock removal, surface precision and crowned profile are explored. Finally, an optimal superfinishing process and a novel turnaround device are designed to improve surface integrity.

Findings
The experimental results show that as the oilstone pressure increases, the stock removal first increases and then remains stable. This hints that the stock removal of a single-time superfinishing process has an upper limit. In the current conditions, the maximum stock removal is 6 µm. Double-time superfinishing process and the turnover device can effectively eliminate the white and dark layers and improve the symmetric of roller profile. In addition, the surface precision is also improved.

Originality/value
The surface integrity of bearing rollers is very important to the application of industry field. The findings and the methods in the study can be helpful to improve the surface integrity of the bearing rollers.
How peer feedback affects knowledge contribution in online innovation communities: a social identity perspective
Authors: Wang Liya , Cong Rong , Wang Shuxiang , Li Sitan , Wang Ya 
Published: May 2023

PurposeThe research aims to explore the influence mechanism of peer feedback and users' knowledge contribution behavior. This study draws on the social identity theory and considers social identity as a mediating factor into the research framework.Design/methodology/approachThis paper collected users' activity data of 142,191 ideas submitted by 76,647 users from the MIUI community between October 2010 and May 2018 via Python software, and data were processed using Stata 16.0.FindingsThe results indicate that knowledge feedback and social feedback positively influence users' knowledge contribution (quantity and quality), respectively. User's cognitive identity positively mediates the relationship between peer feedback and knowledge contribution behavior, affective identity positively mediates the relationship between peer feedback and knowledge contribution behavior, while evaluative identity positively mediates the relationship between peer feedback and knowledge contribution quality, but there is no mediating effect between peer feedback and knowledge contribution quantity.Originality/valueThis study advances knowledge management by highlighting peer feedback on online innovation communities. By demonstrating the significant mediating effect of social identity, this study empirically clarifies the relationships of peer feedback (knowledge feedback and social feedback) to specific dimensions of knowledge contribution, thereby providing managerial guidance to the online innovation community on incentivizing and managing user interaction to foster the innovation development of firms.
Involvement of ribonuclease Y in pilus production by M49 Streptococcus pyogenes strain via modulation of messenger RNA level of transcriptional regulator
Authors: Kubota Seiko , Nakata Masanobu , Hirose Yujiro , Yamaguchi Masaya , Kreikemeyer Bernd , Uzawa Narikazu , Sumitomo Tomoko , Kawabata Shigetada 
Published: May 2023

AbstractStreptococcus pyogenes displays a wide variety of pili, which is largely dependent on serotype. A distinct subset of S. pyogenes strains that possess the Nra transcriptional regulator demonstrates thermoregulated pilus production. Findings obtained in the present study of an Nra‐positive serotype M49 strain revealed involvement of conserved virulence factor A (CvfA), also referred to as ribonuclease Y (RNase Y), in virulence factor expression and pilus production, while a cvfA deletion strain showed reduced pilus production and adherence to human keratinocytes as compared with wild‐type and revertant strains. Furthermore, transcript levels of pilus subunits and srtC2 genes were decreased by cvfA deletion, which was remarkable at 25°C. Likewise, both messenger RNA (mRNA) and protein levels of Nra were remarkably decreased by cvfA deletion. Whether the expression of other pilus‐related regulators, including fasX and CovR, was subject to thermoregulation was also examined. While the mRNA level of fasX, which inhibits cpa and fctA translation, was decreased by cvfA deletion at both 37°C and 25°C, CovR mRNA and protein levels, as well as its phosphorylation level were not significantly changed, suggesting that neither fasX nor CovR is necessarily involved in thermosensitive pilus production. Phenotypic analysis of the mutant strains revealed that culture temperature and cvfA deletion had varied effects on streptolysin S and SpeB activities. Furthermore, bactericidal assay data showed that cvfA deletion decreased the rate of survival in human blood. Together, the present findings indicate that CvfA is involved in regulation of pilus production and virulence‐related phenotypes of the serotype M49 strain of S. pyogenes.
AGAINST THE COLONIZATION OF URBAN DEVELOPMENT: The Top‐dong Right to the City Movement in Jeju, South Korea
Authors: Oh Youjeong 
Published: May 2023

AbstractThe Top‐dong Movement was an extensive residents’ resistance mobilization against the Top‐dong Public Water Reclamation project in the late 1980s in Jeju, South Korea. Starting as a local female divers’ struggle for subsistence, the Top‐dong Movement grew into a collective action to reveal the illegalities of the project, demand that profits should be fairly shared and assert self‐determination. State‐led development of Jeju in the post‐Korean war period functioned to render the island an extractive periphery during South Korea's capitalist modernization. Within that context, the Top‐dong reclamation project exemplifies how urban development projects create colonial conditions in local communities by dispossessing them of land and the means of subsistence, commodifying public resources and extracting profits. Jeju islanders reacted by claiming specific rights: female divers’ collective rights to public water and the means of livelihood against dispossession; local residents’ rights to control developmental profits against extraction; and islanders’ rights to participate in decision‐making processes against exclusion. Bridging Lefebvre's two concepts—colonization and the right to the city, this article argues that the historically situated, place‐based right to the city movement revealed the colonization involved in urban development and performed practices of decolonization.
Systemic review and meta‐analysis of the association between interleukin‐10 and Takayasu arteritis
Authors: Zhou Hang , Zhou Boyang , Liang Surong , Zhao Jian 
Published: May 2023

AbstractObjectiveThe aim of this meta‐analysis is to investigate the relationship between interleukin (IL)‐10 levels and its polymorphism and Takayasu arteritis (TAK).MethodsFive databases including PubMed, Web of Science, Ovid, Sinomed and China National Knowledge Infrastructure (CNKI) were gone through from inception to March 31, 2022. Studies were screened according to the inclusion and exclusion criteria. Newcastle‐Ottawa Scale (NOS) was applied to assess study quality. Strengths of association were evaluated by odds ratio (OR) and 95% CI. The T v. t (allele contrast), TT v. tt (homozygous contrast), Tt vs tt (heterozygous contrast), TT + Tt vs tt (dominant contrast) and TT vs Tt + tt (recessive contrast) models were adopted.ResultsSeven studies were included. No significant relationship between IL‐10 and TAK was detected in the included patients (P > 0.05). The levels of IL‐10 were lower in the active group than those in the stable group, which was −0.47 (95% CI: −0.93, 0.00) (P = 0.05). No significant relationships between IL‐10 and TAK were found under all contrasts for polymorphisms rs1800871, rs1800872 and rs1800896 (P > 0.05).ConclusionsThere was no significant difference in IL‐10 levels between TAK patients and control subjects. The levels of IL‐10 were lower in TAK patients in the active stage. There was no significant association between IL‐10 gene polymorphisms and TAK. Further well‐designed studies with larger sample sizes in patients with different stages are needed.
Commitment and cheap talk in search deterrence
Authors: Pan Siqi , Zhao Xin 
Published: May 2023

AbstractWe investigate the role of sellers' commitment power in discouraging consumer search. Theoretically, lack of commitment power transforms sellers' search‐deterring claims into cheap talk, eliminating sellers' ability to deter search in some market environments. However, our experiments show buyers' search decisions are significantly affected by sellers' cheap talk. When future prices are not adjustable, sellers falsely claim exploding offers to deter search. When future prices are adjustable, sellers falsely claim low future prices to lure consumers to return after search and exploit these “captive” consumers with subsequent price hikes. A behavioral model with naïve buyers explains our experimental findings.
A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term inflammatory exposure: A Canadian Longitudinal Study on Aging analysis
Authors: Verschoor Chris P. , Vlasschaert Caitlyn , Rauh Michael J. , Paré Guillaume 
Published: May 2023

AbstractA key hallmark in the age‐related dysfunction of physiological systems is disruption related to the regulation of inflammation, often resulting in a chronic, low‐grade inflammatory state (i.e., inflammaging). In order to understand the causes of overall system decline, methods to quantify the life‐long exposure or damage related to chronic inflammation are critical. Here, we characterize a comprehensive epigenetic inflammation score (EIS) based on DNA methylation loci (CpGs) that are associated with circulating levels of C‐reactive protein (CRP). In a cohort of 1446 older adults, we show that associations to age and health‐related traits such as smoking history, chronic conditions, and established measures of accelerated aging were stronger for EIS than CRP, while the risk of longitudinal outcomes such as outpatient or inpatient visits and increased frailty were relatively similar. To determine whether variation in EIS actually reflects the cellular response to chronic inflammation we exposed THP1 myelo‐monocytic cells to low levels of inflammatory mediators for 14 days, finding that EIS increased in response to both CRP (p = 0.011) and TNF (p = 0.068). Interestingly, a refined version of EIS based only on those CpGs that changed in vitro was more strongly associated with many of the aforementioned traits as compared to EIS. In conclusion, our study demonstrates that EIS outperforms circulating CRP with regard to its association to health‐traits that are synonymous with chronic inflammation and accelerated aging, and substantiates its potential role as a clinically relevant tool for stratifying patient risk of adverse outcomes prior to treatment or following illness.