bluuebunny/crossref_metadata_2025_split huggingface dataset:
The SAMI Galaxy Survey: Environmental analysis of the orbital structures of passive galaxies
Authors: Santucci Giulia , Brough Sarah , van de Sande Jesse , McDermid Richard , Barsanti Stefania , Bland-Hawthorn Joss , Bryant Julia J , Croom Scott M , Lagos Claudia , Lawrence Jon S , Owers Matt S , van de Ven Glenn , Vaughan Sam P , Yi Sukyoung K 
Published: March 2023

ABSTRACT
Most dynamical models of galaxies to date assume axisymmetry, which is not representative of a significant fraction of massive galaxies. We have built triaxial orbit-superposition Schwarzschild models of galaxies observed by the SAMI Galaxy Survey, in order to reconstruct their inner orbital structure and mass distribution. The sample consists of 153 passive galaxies with total stellar masses in the range 109.5 to $10^{12} \, {\rm M}_{\odot }$. We present an analysis of the internal structures and intrinsic properties of these galaxies as a function of their environment. We measure their environment using three proxies: central or satellite designation, halo mass and local 5th nearest neighbour galaxy density. We find that although these intrinsic properties correlate most strongly with stellar mass, environment does play a secondary role: at fixed stellar mass, galaxies in the densest regions are more radially anisotropic. In addition, central galaxies, and galaxies in high local densities show lower values of edge-on spin parameter proxy λRe, EO. We also find suggestions of a possible trend of the fractions of orbits with environment for lower mass galaxies (between 109.5 and $10^{11} \, {\rm M}_{\odot }$) such that, at fixed stellar mass, galaxies in higher local densities and halo mass have higher fractions of hot orbits and lower fractions of warm orbits. Our results demonstrate that after stellar mass, environment does play a role in shaping present-day passive galaxies.
Integratedde novogene prediction and peptide assembly of metagenomic sequencing data
Authors: Thippabhotla Sirisha , Liu Ben , Podgorny Adam , Yooseph Shibu , Yang Youngik , Zhang Jun , Zhong Cuncong 
Published: March 2023

AbstractMetagenomics is the study of all genomic content contained in given microbial communities. Metagenomic functional analysis aims to quantify protein families and reconstruct metabolic pathways from the metagenome. It plays a central role in understanding the interaction between the microbial community and its host or environment. De novo functional analysis, which allows the discovery of novel protein families, remains challenging for high-complexity communities. There are currently three main approaches for recovering novel genes or proteins: de novo nucleotide assembly, gene calling and peptide assembly. Unfortunately, their information dependency has been overlooked, and each has been formulated as an independent problem. In this work, we develop a sophisticated workflow called integrated Metagenomic Protein Predictor (iMPP), which leverages the information dependencies for better de novo functional analysis. iMPP contains three novel modules: a hybrid assembly graph generation module, a graph-based gene calling module, and a peptide assembly-based refinement module. iMPP significantly improved the existing gene calling sensitivity on unassembled metagenomic reads, achieving a 92–97% recall rate at a high precision level (&gt;85%). iMPP further allowed for more sensitive and accurate peptide assembly, recovering more reference proteins and delivering more hypothetical protein sequences. The high performance of iMPP can provide a more comprehensive and unbiased view of the microbial communities under investigation. iMPP is freely available from https://github.com/Sirisha-t/iMPP.
Magnetic activity variability from Hα line intensive monitoring of two F-type stars with a hot Jupiter, τ Bootis A and υ Andromedae A
Authors: Lee Sanghee , Notsu Yuta , Sato Bun’ei 
Published: March 2023

Abstract
We report the results of intensive monitoring of the variability in the Hα line for two F-type stars, τ Boo and υ And, over the last four years 2019–2022, in order to investigate their stellar magnetic activity. The 4 yr Hα line intensity data taken with the 1.88 m reflector at the Okayama Branch Office, Subaru Telescope, shows the existence of a possible ∼123 d magnetic activity cycle for τ Boo. The result of the Hα variability as another tracer of the magnetic activity on the chromosphere is consistent with previous studies of the Ca ii H&K line and suggests that the magnetic activity cycle persists in τ Boo. For υ And, we suggest a quadratic long-term trend in the Hα variability. Meanwhile, the short-term monitoring shows no significant period corresponding to specific variations likely induced by their hot Jupiter in both cases (≈3.31 and 4.62 d, respectively). In this Hα observation, we could not find any signature of the star–planet magnetic interaction. It is speculated that the detected magnetic activity variability of the two F-type stars is related to the stellar intrinsic dynamo.
Paternalism in Historical Context: Helmet and Seatbelt Legislation in the UK
Authors: Weston Janet 
Published: March 2023

Abstract
Paternalism is a frequent source of anxiety and scholarly enquiry within public health. This article examines debate in the UK from the 1950s to the early 1980s about two quintessentially paternalistic laws: those making it compulsory to use a motorcycle helmet, and a car seatbelt. This kind of historical analysis, looking at change over time and the circumstances that prevent or enable such change, draws attention to two significant features: the contingent nature of that which is perceived as paternalistic and therefore objectionable, and the wide range of arguments that can be marshalled for and against. It suggests that paternalism became a particularly disruptive accusation in the UK of the 1970s in relation to seatbelts, thanks to the population that would be affected and the wider socio-political context. It also suggests that arguments about the social cost of death and injury on the roads, along with overt acceptance that some element of paternalism could be acceptable, proved influential—as was the sense of inevitability that 10 years of regular debate helped to create.
Elemental composition and stoichiometry of krill and salps
Authors: Plum Christoph , Möller Fenja-Marie , Smykala Mike , Moorthi Stefanie 
Published: March 2023

AbstractKrill and salps play a pivotal role in marine food webs and ocean biogeochemistry, yet little is known about their stoichiometry, which is crucial for our understanding of the consequences of key grazer population shifts for ecosystem functioning. To assess differences in stoichiometric requirements, we compared the elemental composition of carbon (C), nitrogen (N) and phosphorus (P) in body tissue and gut content of Euphausia superba and Salpa thompsoni collected along the Northern Antarctic Peninsula and conducted a systematic literature review on the stoichiometry of 33 euphausiid and 19 salp species. Our data revealed significantly lower body C:P and N:P ratios but higher gut content N:P in S. thompsoni compared with E. superba, suggesting higher P uptake. In contrast, literature data showed higher C:N, C:P and N:P ratios in salps, potentially indicating lower nutrient demand compared with krill. However, literature data exhibited high intra- and interspecific variability potentially driven by organism size, seasonal or latitudinal variations, emphasizing that nutritional requirements are not only related to the target species, but also to its habitat. Our study provides valuable stoichiometric information for future experimental and modeling studies, fostering our ability to predict the future role of krill and salps for ocean biogeochemistry.
Uptake of oomycete RXLR effectors into host cells by clathrin-mediated endocytosis
Authors: Wang Haixia , Wang Shumei , Wang Wei , Xu Lin , Welsh Lydia R J , Gierlinski Marek , Whisson Stephen C , Hemsley Piers A , Boevink Petra C , Birch Paul R J 
Published: March 2023

Abstract
Filamentous (oomycete and fungal) plant pathogens deliver cytoplasmic effector proteins into host cells to facilitate disease. How RXLR effectors from the potato late blight pathogen Phytophthora infestans enter host cells is unknown. One possible route involves clathrin-mediated endocytosis (CME). Transient silencing of NbCHC, encoding clathrin heavy chain, or the endosome marker gene NbAra6 encoding a Rab GTPase in the model host Nicotiana benthamiana, attenuated P. infestans infection and reduced translocation of RXLR effector fusions from transgenic pathogen strains into host cells. By contrast, silencing PP1c isoforms, susceptibility factors not required for endocytosis, reduced infection but did not attenuate RXLR effector uptake. Endosome enrichment by ultracentrifugation and sucrose gradient fractionation revealed co-localization of RXLR effector Pi04314-RFP with clathrin-coated vesicles. Immunopurification of clathrin- and NbAra6-associated vesicles during infection showed that RXLR effectors Pi04314-RFP and AvrBlb1-RFP, but not apoplastic effector PiSCR74-RFP, were co-immunoprecipitated during infection with pathogen strains secreting these effectors. Tandem mass spectrometry analyses of proteins co-immunoprecipitated with NbAra6-GFP during infection revealed enrichment of host proteins associated with endocytic vesicles alongside multiple pathogen RXLR effectors, but not apoplastic effectors, including PiSCR74, which do not enter host cells. Our data show that the uptake of P. infestans RXLR effectors into plant cells occurs via CME.
The transcription factor CitZAT5 modifies sugar accumulation and hexose proportion in citrus fruit
Authors: Fang Heting , Shi Yanna , Liu Shengchao , Jin Rong , Sun Jun , Grierson Donald , Li Shaojia , Chen Kunsong 
Published: March 2023

Abstract
Sugars are fundamental to plant developmental processes. For fruits, the accumulation and proportion of sugars play crucial roles in the development of quality and attractiveness. In citrus (Citrus reticulata Blanco.), we found that the difference in sweetness between mature fruits of “Gongchuan” and its bud sport “Youliang” is related to hexose contents. Expression of a SuS (sucrose synthase) gene CitSUS5 and a SWEET (sugars will eventually be exported transporter) gene CitSWEET6, characterized by transcriptome analysis at different developmental stages of these 2 varieties, revealed higher expression levels in “Youliang” fruit. The roles of CitSUS5 and CitSWEET6 were investigated by enzyme activity and transient assays. CitSUS5 promoted the cleavage of sucrose to hexoses, and CitSWEET6 was identified as a fructose transporter. Further investigation identified the transcription factor CitZAT5 (ZINC FINGER OF ARABIDOPSIS THALIANA) that contributes to sucrose metabolism and fructose transportation by positively regulating CitSUS5 and CitSWEET6. The role of CitZAT5 in fruit sugar accumulation and hexose proportion was investigated by homologous transient CitZAT5 overexpression, -VIGS, and -RNAi. CitZAT5 modulates the hexose proportion in citrus by mediating CitSUS5 and CitSWEET6 expression, and the molecular mechanism explained the differences in sugar composition of “Youliang” and “Gongchuan” fruit.
Diversity beyond density: Experienced social mixing of urban streets
Authors: Fan Zhuangyuan , Su Tianyu , Sun Maoran , Noyman Ariel , Zhang Fan , Pentland Alex ‘Sandy’ , Moro Esteban 
Published: March 2023

Abstract
Urban density, in the form of residents’ and visitors’ concentration, is long considered to foster diverse exchanges of interpersonal knowledge and skills, which are intrinsic to sustainable human settlements. However, with current urban studies primarily devoted to city- and district-level analyses, we cannot unveil the elemental connection between urban density and diversity. Here we use an anonymized and privacy-enhanced mobile dataset of 0.5 million opted-in users from three metropolitan areas in the United States to show that at the scale of urban streets, density is not the only path to diversity. We represent the diversity of each street with the experienced social mixing (ESM), which describes the chances of people meeting diverse income groups throughout their daily experience. We conduct multiple experiments and show that the concentration of visitors only explains 26% of street-level ESM. However, adjacent amenities, residential diversity, and income level account for 44% of the ESM. Moreover, using longitudinal business data, we show that streets with an increased number of food businesses have seen an increased ESM from 2016 to 2018. Lastly, although streets with more visitors are more likely to have crime, diverse streets tend to have fewer crimes. These findings suggest that cities can leverage many tools beyond density to curate a diverse and safe street experience for people.
Why Dreaming Worlds aren’t Nearby Possible Worlds
Authors: Simpson James 
Published: March 2023

AbstractA familiar anti-sceptical response (à la Sosa) to radical sceptical scenarios employs the safety of knowledge. Radical sceptical scenarios are purported to be too modally remote to really threaten knowledge of ordinary propositions. Why? Because knowledge requires safety, and safety requires the target belief to be true in all nearby possible worlds, but radical sceptical scenarios purportedly take place at distant possible worlds. Hence, the safety theorist claims that radical sceptical scenarios don’t challenge our knowledge of ordinary propositions. But it's alleged by Sosa and others that there's one radical sceptical scenario that can’t be dismissed so easily: the dream scenario. After all, unlike evil demons and brains in vats, ‘dreaming is a daily part of our lives…it is too close for comfort’. In this paper, I sketch an argument to the effect that there's good reason to think that the dream of dream scepticism describes a modally remote possibility, in which case I argue that if the safety-based anti-sceptical response is successful against the evil demon sceptical scenario, the brain in a vat sceptical scenario, and other Cartesian sceptical scenarios in this mould, then it's successful against the dream sceptical scenario as well.
Dynamic Asset-Backed Security Design
Authors: Ozdenoren Emre , Yuan Kathy , Zhang Shengxing 
Published: March 2023

Abstract
Borrowers obtain liquidity by issuing securities backed by the current period payoff and resale price of a long-lived collateral asset, and they are privately informed about the payoff distribution. Asset price can be self-fulfilling: a higher asset price lowers adverse selection and allows borrowers to raise greater funding, which makes the asset more valuable, leading to multiple equilibria. Optimal security design eliminates multiple equilibria, improves welfare, and can be implemented as a repo contract. Persistent adverse selection lowers debt funding, generates volatility in asset prices, and exacerbates credit crunches. The theory demonstrates the role of asset-backed securities on stability of market-based financial systems.
IFN-beta and EIF2AK2 are potential biomarkers for interstitial lung disease in anti-MDA5 positive dermatomyositis
Authors: Liu Yiming , Feng Shuo , Liu Xingyue , Tang Yujie , Li Xiaoling , Luo Chengyu , Tao Jinhui 
Published: March 2023

Abstract

Objective
DM with positive anti-melanoma differentiation-related gene 5 (MDA5) antibody is an autoimmune disease with multiple complications. Interstitial lung diseases (ILDs) are significantly associated with DM and are particularly related to MDA5+ DM. This article aims to explore potential molecular mechanisms and develop new diagnostic biomarkers for MDA5+ DM-ILD.

Methods
The series matrix files of DM and non-specific interstitial pneumonia (NSIP) were downloaded from the Gene Expression Omnibus (GEO) database to identify the differentially expressed genes (DEGs). Gene set enrichment analysis (GSEA) was used to screen the common enriched pathways related to DM and NSIP. Next, the co-expressed differential expressed genes (co-DEGs) between MDA5+, MDA5− and NSIP groups were identified by Venn plots, and then selected for different enrichment analyses and protein–protein interaction (PPI) network construction. The mRNA expression levels of IFN-beta and EIF2AK2 were measured by RT-qPCR. The protein expression levels of IFN-beta were measured by ELISA.

Results
Using GSEA, the enriched pathway ‘herpes simplex virus 1 infection’ was both up-regulated in DM and NSIP. Enrichment analysis in MDA5+ DM, MDA5− DM and NSIP reported that the IFN-beta signalling pathway was an important influencing factor in the MDA5+ DM-ILD. We also identified that eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) was an important gene signature in the MDA5+ DM-ILD by PPI analysis. The expression levels of IFN-beta and EIF2AK2 were significantly increased in MDA5+ DM-ILD patients.

Conclusions
IFN-beta and EIF2AK2 contributed to the pathogenesis of MDA5+ DM-ILD, which could be used as potential therapeutic targets.
Schizophrenia and Increased Distrust-Based Competitiveness in Interpersonal Interactions: A Serial Process Model
Authors: Ellett Lyn , Wildschut Tim , Chadwick Paul 
Published: March 2023

Abstract

Background and Hypothesis
Game theory paradigms, such as the Prisoner’s Dilemma Game (PDG), have been used to study nonclinical paranoia, though research using clinical populations has been scarce. We test our novel theoretical model that schizophrenia leads to competitiveness in interpersonal interactions, and that this link is serially mediated by trait paranoia, state paranoia, and distrust.

Study Design
In this quasi-experimental study, individuals with schizophrenia spectrum diagnoses with current persecutory delusions (n = 46) and a nonclinical control group (n = 43) played the PDG, and completed measures of trait paranoia, state paranoia, and distrust.

Study Results
Individuals with schizophrenia competed more in the PDG than the control group. Supporting our theoretical model, all direct effects were significant: schizophrenia was associated with higher trait paranoia (H1); trait paranoia predicted state paranoia in the PDG (H2); state paranoia in the PDG predicted distrust of the opponent in the PDG (H3); and distrust predicted competition in the PDG (H4). The hypothesized indirect effect of schizophrenia on competition in the PDG via trait paranoia, state paranoia, and distrust was supported in a serial mediation model (H5).

Conclusions
The findings make clear theoretical and methodological contributions. We provide the first evidence for a theoretical process model by which schizophrenia leads to competitiveness in interpersonal interactions via trait paranoia, state paranoia, and distrust. Game theory paradigms, and the PDG in particular, are important for advancing theory and research on paranoia as it occurs in both clinical and nonclinical populations.
Temporal shifts in root exudates driven by vegetation restoration alter rhizosphere microbiota inRobinia pseudoacaciaplantations
Authors: Li Jiajia , Fan Miaochun , Yang Le , Yang Zhen , Shangguan Zhouping 
Published: March 2023

AbstractPlant–soil–microbiota interactions mediated by root exudates regulate plant growth and drive rhizosphere microbial feedbacks. It remains unknown how root exudates affect rhizosphere microbiota and soil functions in the course of forest plantation restoration. The metabolic profiles of tree root exudates are expected to shift with stand age, leading to variation in rhizosphere microbiota structure, and in turn, potentially altering soil functions. To unravel the effects of root exudates, a multi-omics study was conducted using untargeted metabonomic profiling, high-throughput microbiome sequencing and functional gene array. The interactions among root exudates, rhizosphere microbiota and nutrient cycling-related functional genes were explored under 15- to 45-year-old Robinia pseudoacacia plantations in the Loess Plateau region of China. Root exudate metabolic profiles, rather than chemodiversity, markedly changed with an increase in stand age. A total of 138 age-related metabolites were extracted from a key module of root exudates. The relative contents of six biomarker metabolites, such as glucose-1-phosphate, gluconic acid and N-acetylneuraminic acid, increased distinctly over time. The biomarker taxa (16 classes) of rhizosphere microbiota varied in a time-sensitive manner, which played potential roles in nutrient cycling and plant health. Nitrospira, Alphaproteobacteria and Acidobacteria were enriched in the rhizosphere of older stands. Key root exudates influenced functional gene abundances in the rhizosphere via direct effects or indirectly through biomarker microbial taxa (e.g., Nitrososphaeria). Overall, root exudates and rhizosphere microbiota are essential for soil function maintenance in R. pseudoacacia plantation restoration.
Hard and Soft Skills in Vocational Training: Experimental Evidence from Colombia
Authors: Barrera-Osorio Felipe , Kugler Adriana , Silliman Mikko 
Published: March 2023

Abstract
This paper studies the effects of an oversubscribed job-training program on skills and labor-market outcomes using both survey and administrative data. Overall, vocational training improves labor-market outcomes, particularly by increasing formal employment. A second round of randomization evaluates how applicants to otherwise similar job-training programs are affected by the extent that hard versus soft skills are emphasized in the curriculum. Admission to a vocational program that emphasizes technical relative to social skills generates greater short-term benefits, but these relative benefits quickly disappear, putting participants in the technical training on equal footing with their peers from the soft-skill training in under a year. Results from an additional randomization suggest that offering financial support for transportation and food increases the effectiveness of the program. The program fails to improve the soft skills or broader labor-market outcomes of women.
The roles of neuroinflammation and glutamatergic excitotoxicity in treatment-resistant depression
Authors: Candee Ryan , Wilkenson Rachel , Schreiber Molly , DeCenzo Megan 
Published: March 2023

ABSTRACT
Major depressive disorder affects nearly 20% of people during their lifetime. A growing body of evidence supports the theory that neuroinflammation plays a prominent role in the neurobiology of depression, which implicates glutamate and gamma aminobutyric acid as key factors in the pathophysiology of the disease process. This article reviews the pathologic pathways of glutamate excess in the central nervous system and how they may be implicated in the underlying disorder of treatment-resistant depression and targeted for treatment.
Recognizing and managing hydrocephalus in children
Authors: Alois Corinne I. , Luntz Allison 
Published: March 2023

ABSTRACT
Hydrocephalus is one of the most common indications for pediatric neurosurgical intervention and is associated with the need for lifelong monitoring. All clinicians should be familiar with the complications that may arise throughout life in these patients so that they can provide timely intervention. This article focuses on the assessment of hydrocephalus, the appropriate diagnostic workup and differential diagnoses, and evidence-based surgical treatments and associated outcomes.