bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Active Phases of Transition Metal Oxide Heterostructures for Highly Efficient Ammonia Electrosynthesis
Authors: Yin Di , Chen Dong , Zhang Yuxuan , Wang Weijun , Quan Quan , Wang Wei , Meng You , Lai Zhengxun , Yang Zhe , Yip SenPo , Wong Chun‐Yuen , Bu Xiuming , Wang Xianying , Ho Johnny C. 
Published: August 2023

AbstractElectrochemically converting waste nitrate (NO3−) into ammonia (NH3) is a green route for both wastewater treatment and high‐value‐added ammonia generation. However, the NO3−‐to‐NH3 reaction involves multistep electron transfer and complex intermediates, making it a grand challenge to drive efficient NO3− electroreduction with high NH3 selectivity. Herein, an in‐operando electrochemically synthesized Cu2O/NiO heterostructure electrocatalyst is proven for efficient NH3 electrosynthesis. In situ Raman spectroscopy reveals that the obtained Cu2O/NiO, induced by the electrochemistry‐driven phase conversion, is the real active phase. This electronically coupled phase can modulate the interfacial charge distribution, dramatically lower the overpotential in the rate‐determining step and thus requiring lower energy input to proceed with the NH3 electrosynthesis. The orbital hybridization calculations further identify that Cu2O is beneficial for NO3− adsorption, and NiO could promote the desorption of NH3, forming an excellent tandem electrocatalyst. Such a tandem system leads to NH3 Faradaic efficiency of 95.6%, a super‐high NH3 selectivity of 88.5% at −0.2 V versus RHE, surpassing most of the NH3 electrosynthesis catalysts at an ultralow reaction voltage.
Clinical Chemotherapeutic Agent Coordinated Copper‐Based Nanoadjuvants for Efficiently Sensitizing Cancer Chemo‐Immunotherapy by Cuproptosis‐Mediated Mitochondrial Metabolic Reprogramming
Authors: Tian Hailong , Duan Jiufei , Li Bowen , Qin Siyuan , Nice Edouard C. , Zhang Wei , Lang Tingyuan , Zhang Haiyuan , Huang Canhua 
Published: August 2023

AbstractChemo‐immunotherapy has shown great success in boosting systemic anti‐tumor effects in the clinic. However, cancer cells can escape the maximum impact of chemotherapy through intracellular symbiotic bacteria and abnormally activated macropinocytosis, while cancer immune evasion is largely facilitated by the programmed cell death 1 ligand 1 (PD‐L1) protein and tumor‐secreted exosomes. To efficiently sensitize chemo‐immunotherapy, the clinical mitoxantrone (MTO) is therefore rationally coordinated with Cu2+ to develop nanoscale metal‐organic frameworks (MTO‐Cu), then loaded with the macropinocytosis and exosome secretion inhibitor amiloride (AMI) and modified with targeted chondroitin sulfate (CS) to form CS/MTO‐Cu@AMI nanoadjuvant. Notably, the coordinated Cu2+ effectively triggers cuproptosis‐induced mitochondrial dysfunction, which activates AMPK pathway‐mediated PD‐L1 protein degradation, deprives energy supply for macropinocytosis and exosome release, and amplifies oxidative stress for deactivating intracellular bacteria, thus efficiently sensitizing chemo‐immunotherapy. Meanwhile, AMI suppresses macropinocytosis and exosome secretion to act synergistically with Cu2+‐caused chemo‐immunotherapy potentiation. Moreover, damaged dsDNA during CS/MTO‐Cu@AMI treatment activates the cGAS‐STING pathway, further evoking the anti‐tumor immunity. Additionally, the attached CS endows CS/MTO‐Cu@AMI with specific tumor targeting and hyaluronidase‐responsive charge reversal property, while MTO‐Cu endows this nanoadjuvant with pH/GSH dual‐responsive release behavior. Therefore, CS/MTO‐Cu@AMI efficiently sensitizes chemotherapy and activates systemic antitumor immunity in vitro and in vivo, providing an innovative solution to potentiate cancer chemo‐immunotherapy.
Dual‐Active Center AgFeCu Nanocatalyst for Tumor Destruction via Self‐Catalytically Enhanced Mild Photothermal Therapy
Authors: Niu Xuegang , Zhu Yang , Ding Chenyu , Ma Jing , Wei Penghui , Lin Yuanxiang , Fang Wenhua , He Qiu , Li Chunwang , Cheng Junjie , Zou Jianhua , Lin Lisen , Chen Xiaoyuan , Kang Dezhi 
Published: August 2023

AbstractMild photothermal therapy (mPTT) has emerged as a highly promising approach for tumor ablation. However, the heat‐induced overexpression of heat shock proteins (HSPs) limits its efficacy by increasing cellular temperature tolerance. Herein, a self‐catalytically enhanced mild PTT strategy that directly disrupts the structure of HSPs to restore tumor cell sensitivity is proposed. In the proof‐of‐concept study, AgFeCu nanoparticles (AgFeCu NPs) with dual‐active catalytic centers (Fe‐Cu) and near‐infrared photothermal properties are developed. The AgFeCu NPs can efficiently catalyze the conversion of endogenous hydrogen peroxide into hydroxyl radicals in situ, leading to the degradation of HSPs and enhancing the therapeutic effects of mild PTT mediated by their Ag‐based substrates. Furthermore, AgFeCu NPs can also induce oxidative stress by depleting intracellular glutathione and promoting lipid peroxidation, thereby triggering tumor ferroptosis and resulting in significant tumor elimination in a U87MG murine tumor model. This self‐catalytically enhanced strategy maximizes the efficacy of mild PTT while minimizing damage to healthy tissues, which is expected to provide valuable insights for the development of next‐generation photothermal nanoagents for improved tumor therapeutics.
Synergistic Additives Enabling Stable Cycling of Ether Electrolyte in 4.4 V Ni‐Rich/Li Metal Batteries
Authors: Jiang Zhipeng , Yang Tao , Li Chen , Zou Jiahang , Yang Hanxu , Zhang Qingan , Li Yongtao 
Published: August 2023

AbstractEther‐based electrolytes have high ionic conductivity and good stability toward the lithium metal anode relative to carbonate‐based electrolytes, but they typically exhibit poor oxidation stability (<4 V vs Li+/Li). Most approaches aimed at enhancing the oxidative stability of ether‐based electrolytes, such as “salt‐in‐solvent” and “weakly solvating” strategies, often sacrifice their inherent advantage of high ionic conductivity. Herein, this article proposes a cost‐effective synergistic additive strategy by co‐adding LiNO3 and vinylene carbonate (VC) to achieve an optimized ether‐based electrolyte (OEE) that simultaneously offers high Li‐ion (Li+) conductivity (11.52 mS cm−1 at 20 °C) and high‐voltage stability (4.4 V). LiNO3 and VC can enter the inner solvation shell of the electrolyte, preferentially participating in the film‐forming progress at the electrode surface, leading to the formation of a unique organic–inorganic bilayer interfacial protective layer. This layer could effectively suppress electrolyte side reactions and enhance electrode stability. As a result, the 4.4 V Li‐LiNi0.8Mn0.1Co0.1O2 (NCM811) full cells assembled with the OEE exhibit stable cycling performance at both room temperature and low temperature. This work provides a new approach to the design of ether‐based electrolytes for high‐voltage lithium metal batteries.
Metrology of Individual Small Viruses
Authors: Li Kun , Shah Arjav , Sharma Rajesh Kumar , Adkins Raymond , Marjanovic Tihomir , Doyle Patrick S. , Garaj Slaven 
Published: August 2023

AbstractViruses come in various shapes and sizes, and understanding their morphology is central to understanding their activity and function. The need for fast recognition and real‐time fingerprinting methods for pathogenic viruses is a critical bottleneck in implementing many diagnostic and therapeutic techniques. In this work, nanopore tomography (NT) is implemented for fast measurements of the characteristic dimensions of viruses and the optimal operating conditions are explored. Using a small filamentous bacteriophage as a model, it is demonstrated that NT can detect geometrical features in a few‐nanometer regime, with high throughput and accuracy, in aqueous conditions. The instrumental parameters are optimized to obtain virus diameter measurements that are robust to the uncertainties of the external parameters. Furthermore, NT is critically compared to various single‐particle imaging techniques, with a particular emphasis on emerging helium ion microscopy (HIM). It is shown that, with proper operating procedures, HIM can reach a nanometer‐scale resolution in viral metrology, while retaining a high throughput second only to NT. The high throughput of both techniques can foster sufficient statistics for a precise exploration of viral heterogeneity.
Stretch‐Tolerant Waterproof and Self‐cleaning CBNPs/Graphene Strain Sensor for Multifunctional Applications
Authors: Duan Jialin , Liu Jiayao , Wang Chaolun , Cai Chunhua , Lyu Liangjian , Sun Litao , Wu Xing , Bi Hengchang 
Published: August 2023

AbstractWearable strain sensors are widely used in bionic robots and wearable electronic devices. However, such devices inevitably work in degradative environments such as under wet conditions and contaminants, deteriorating the sensing performance and stability. In this work, a stretch‐tolerant superhydrophobic, self‐cleaning graphene‐based strain sensor with high sensitivity, is reported using prestretching strategy. The stretch‐tolerant superhydrophobic surface of the sensor is prepared by attaching carbon black nanoparticles to the Ecoflex substrate for constructing surface roughness and modifying with polydimethylsiloxane for achieving low surface energy under stretched condition (50% strain), which endow the sensors with an outstanding self‐cleaning performance for various contaminants. Moreover, the sensor retains excellent super‐hydrophobicity even under stretching. The sensor is also insensitive to common liquids in daily life including water, such as tea, milk, and coffee. Furthermore, the proposed strain sensor achieves wide sensing ranges (strain over 100%) and has a superior sensitivity (gauge factor up to 653.4 at 90% stretching), which shows great promising in accurate human motions monitoring both in the air and underwater. Besides, by placing the strain sensor on a bridge, the number of vehicles on the bridge can be detected, which exhibits an ideal platform for real‐time traffic flow monitoring.
Unexpected Emission Behaviors of Rhodamine Derivatives in PVA After UV‒Green Light Excitation
Authors: Zhang Shiguo , Liu Guanyu , Chen Junwu , Zhang Yuefa , Sun Qikun , Xue Shanfeng , Yang Wenjun 
Published: August 2023

AbstractRhodamine derivatives are a class of common fluorescent dyes and are usually co‐doped with room temperature phosphorescence (RTP) polymers for tuning colors; here, their unusual luminescence properties in polyvinyl alcohol are first disclosed. The doped polyvinyl alcohol (PVA) films are photo‐excited for 0.5‒1 min and emit orange and red afterglows with lifetimes of over 1 s at room temperature. More unexpectedly, the respective prompt and delayed room temperature emission colors and spectra are identical, and the red‐shifted afterglows are observed in liquid nitrogen, indicating that room temperature afterglow is thermally activated delayed fluorescence (TADF). Their molecular structure features and quantum chemical calculations support this inference. Impressively, the room temperature afterglows are visible light excitable up to 540 nm since the maximal and strong absorption bands are in green regions. Hence, this work discloses unknown excitation and emission properties of rhodamine derivatives and provides the really visible light excited yet intrinsic red TADF afterglows for the first time.
A Rational Design of Isoindigo‐Based Conjugated Microporous n‐Type Semiconductors for High Electron Mobility and Conductivity
Authors: Ranjeesh Kayaramkodath Chandran , Rezk Ayman , Martinez Jose Ignacio , Gaber Safa , Merhi Areej , Skorjanc Tina , Finšgar Matjaž , Luckachan Gisha Elizabeth , Trabolsi Ali , Kaafarani Bilal R. , Nayfeh Ammar , Shetty Dinesh 
Published: August 2023

AbstractThe development of n‐type organic semiconductors has evolved significantly slower in comparison to that of p‐type organic semiconductors mainly due to the lack of electron‐deficient building blocks with stability and processability. However, to realize a variety of organic optoelectronic devices, high‐performance n‐type polymer semiconductors are essential. Herein, conjugated microporous polymers (CMPs) comprising isoindigo acceptor units linked to benzene or pyrene donor units (BI and PI) showing n‐type semiconducting behavior are reported. In addition, considering the challenges of deposition of a continuous and homogeneous thin film of CMPs for accurate Hall measurements, a plasma‐assisted fabrication technique is developed to yield uniform thin films. The fully conjugated 2D networks in PI‐ and BI‐CMP films display high electron mobility of 6.6 and 3.5 cm2 V−1 s−1, respectively. The higher carrier concentration in PI results in high conductivity (5.3 mS cm−1). Both experimental and computational studies are adequately combined to investigate structure–property relations for this intriguing class of materials in the context of organic electronics.
Controlled Release of Hydrogen‐Carrying Perfluorocarbons for Ischemia Myocardium‐Targeting 19F MRI‐Guided Reperfusion Injury Therapy
Authors: Nie Chaoqun , A Rong , Wang Jing , Pan Shuang , Zou Rentong , Wang Bin , Xi Shuiqing , Hong Xiaojian , Zhou Meifang , Wang Haoyu , Yu Mengshu , Wu Lina , Sun Xilin , Yang Wei 
Published: August 2023

AbstractHydrogen gas is recently proven to have anti‐oxidative and anti‐inflammation effects on ischemia‐reperfusion injury. However, the efficacy of hydrogen therapy is limited by the efficiency of hydrogen storage, targeted delivery, and controlled release. In this study, H2‐PFOB nanoemulsions (NEs) is developed with high hydrogen loading capacity for targeted ischemic myocardium precision therapy. The hydrogen‐carrying capacity of H2‐PFOB NEs is determined by gas chromatography and microelectrode methods. Positive uptake of H2‐PFOB NEs in ischemia‐reperfusion myocardium and the influence of hydrogen on 19F‐MR signal are quantitatively visualized using a 9.4T MR imaging system. The biological therapeutic effects of H2‐PFOB NEs are examined on a myocardial ischemia‐reperfusion injury mouse model. The results illustrated that the developed H2‐PFOB NEs can efficaciously achieve specific infiltration into ischemic myocardium and exhibit excellent antioxidant and anti‐inflammatory properties on myocardial ischemia‐reperfusion injury, which can be dynamically visualized by 19F‐MR imaging system. Moreover, hydrogen burst release induced by low‐intensity focused ultrasound (LIFU) irradiation further promotes the therapeutic effect of H2‐PFOB NEs with a favorable biosafety profile. In this study, the potential therapeutic effects of H2‐PFOB NEs is fully unfolded, which may hold great potential for future hydrogen‐based precision therapeutic applications tailored to ischemia‐reperfusion injury.
2D MoTe2/MoS2−xOx Van der Waals Heterostructure for Bimodal Neuromorphic Optoelectronic Computing
Authors: Xiao Yang , Li Wenbo , Lin Xiankai , Ji Yi , Chen Zhilong , Jiang Yanping , Liu Qiuxiang , Tang Xingui , Liang Qijie 
Published: August 2023

AbstractThe von Neumann bottleneck has long been a significant obstacle to the advancement of the era of intelligent computing. Neuromorphic devices are considered a promising solution to overcome this bottleneck. These devices draw inspiration from the information processing and computing capabilities of neurons in the human brain. Nevertheless, biomimetic synaptic devices used in neural network computing encounter significant challenges, including high nonlinearity in regulation, limited abundance of state conductance, and restrictions in unidirectional plasticity. Here, a memristor synaptic device is reported that utilizes the ion migration properties of MoTe2/MoS2−xOx heterojunction interface. This device demonstrates remarkable exceptional linearity, extensive dynamic regulation, and bidirectional independently controllable synaptic plasticity when subjected to bimodal regulation using electrical and optical signals. In addition, it shows significant paired‐pulse facilitation, empirical learning, and spike‐timing‐dependent properties. Furthermore, a deep learning framework is constructed to evaluate the reliability of devices in neuromorphic computation. The electronic synapses achieve high accuracy rates of 99.3% and 96.5% in recognizing digits and floral graphics, while photonic synapses achieve 95.3% and 91.5%. These findings emphasize the superior performance of photonic synapses in synaptic computation and provide a potential methodology for integrating multimodal neuromorphic hardware with artificial intelligence computing systems.
Reducing the Surface Reactivity of Alkyl Ammonium Passivation Molecules Enables Highly Efficient Perovskite Solar Cells
Authors: Zheng Lingfang , Shen Lina , Fang Zheng , Song Peiquan , Tian Wanjia , Chen Jingfu , Liu Kaikai , Luo Yujie , Xu Peng , Yang Jinxin , Tian Chengbo , Xie Liqiang , Wei Zhanhua 
Published: August 2023

AbstractThe non‐radiative recombination at the interfaces of perovskite solar cells (PSCs) is a crucial issue that limits the efficiency and stability of the devices. State‐of‐the‐art surface passivation strategies usually utilize alkyl ammonium halides to suppress the non‐radiative recombination of PSCs, but their high surface reactivity leads to the transformation into 2D perovskites under working conditions, limiting the passivation effect and the charge transport of PSCs. Herein, a non‐halide ionic salt 1‐naphthylmethylammonium formate (NMACOOH) is synthesized for surface passivation of perovskite films. In contrast to the traditional 1‐naphthylmethylammonium iodide, NMACOOH treatment hinders the formation of 2D perovskite and forms a thermally stable PbI2‐NMACOOH adduct on the perovskite surface. Surface characterization reveals that NMA+ can passivate the cation vacancies of the 3D perovskite while HCOO− passivates the metallic Pb0 and halide‐vacancy defects. Therefore, the non‐radiative recombination of PSCs is dramatically suppressed and a high open‐circuit voltage of 1.19 V is obtained. Finally, PSCs with high efficiency of 24.75% and improved long‐term stability (98% of the initial efficiency after 1800‐h storage) are obtained. Moreover, the NMACOOH‐passivated devices also show robust operational stability, retaining 83% of the initial efficiency after working for 658 h under continuous one‐sun illumination.
Upcycling of Degraded LiCoO2 Cathodes into High‐Performance Lithium‐Ion Batteries via a Three‐In‐One Strategy
Authors: Liu Zhenzhen , Li Huaimeng , Han Miaomiao , Fang Liang , Fu Zhen , Zhang Haimin , Wang Guozhong , Zhang Yunxia 
Published: August 2023

AbstractFaced with the forthcoming tide of retired lithium‐ion batteries (LIBs), it is imperative to explore effective regeneration and upcycling strategies to alleviate the resource shortage, address environmental pollution, and cater to the demand for high‐energy‐density cathode materials. Herein, a facile, non‐constructive, one‐stone‐for‐three‐birds solid‐phase sintering strategy is proposed to regenerate the degraded LiCoO2 (D‐LCO) cathode and even upgrade its stability at high voltages, in which three birds, i.e., lithium supplement, Li2SO4 coating, and Mn doping into Co sites while N, S doping into Li‐O slabs are simultaneously hit with one stone (one‐pot solid‐phase sintering). Benefiting from these favorable characteristics, the upcycled cathode not only yields high discharge‐specific capacity of 188.2 mAh g−1 at 0.2 C, but also delivers superior cycling performance with 92.5% of capacity retention after 100 cycles (86.4% after 300 cycles) at 0.5 C and excellent rate capability at a high cutoff voltage of 4.5 V, superior to a freshly commercial counterpart. This work is expected to provide meaningful guidance for the upcycling of D‐LCO into high‐energy‐density batteries with long‐term cycling stability.
Metal‐free Reaction of Allenamides with In‐Situ Formed Trifluoromethylnitrones as a Route to Highly Functionalized Isoxazolidines
Authors: Yadav Usha , Chandrasekharan Sanoop P. , Nair Pravya P. , Harikumar Sanjeevni , Mohanan Kishor 
Published: August 2023

AbstractAn additive‐free three‐component reaction of allenamides with in situ generated trifluoromethylnitrones has been uncovered. The reaction afforded an interesting class of trifluoromethylated methyleneisoxazolidines under mild conditions. Additionally, a gram‐scale reaction and the reductive transformation of trifluoromethylated isoxazolidines to aminomethylated allyl alcohol illustrate the high synthetic utility of the present synthetic strategy.
Cu‐Catalyzed Cross‐Coupling Reactions of Enamines and Terminal Alkynes: Access of Propargylamines as Neurodegenerative Disorder Agents
Authors: Mohan Lakavathu , Lee Ji Eun , Srinivasarao Mande , Cutright Alexander J. , Raju Selvam , Stokes Sean. L. , Emerson Joseph. P. , Kim Jae Hong 
Published: August 2023

AbstractReactions between enamine analogues and terminal alkynes were explored. Copper(I) complex of 1,10‐phenanthroline catalyzed these reactions to generate a diastereoselective propargylamines via C−C bond formation. In the presence of Zn2+, the chiral propargylamines converted into the β‐allenoates with an excellent yield and enantioselectivity achieved up to 99 %. Models of synthesized propargylamines were used for molecular docking and dynamic simulations, which indicate that this class of molecules shows promise for anti‐neurodegenerative activity.
Recent Advancement on the Organocatalyzed Asymmetric Conjugate Addition using Maleimide as a Potential Substrate
Authors: Jana Barnali , Mondal Monotosh , Halder Shibashis , Mahata Atanu , Saurav Sameer , Paladhi Sushovan 
Published: August 2023

AbstractAsymmetric organocatalytic 1,4‐conjugate addition is considered as an effective, powerful and sustainable method for carbon‐carbon bond formation. The core structure of maleimides or succinimides were found in several bioactive molecules as well as in natural products. Unprotected and protected maleimides were employed as an electrophile to construct novel succinimide based organic molecules. The rapid development of several new effective and prominent methodologies encourages us to write a review by summarizing the recent updates. In this review, we present an overview of the past 10 years progress on the asymmetric organocatalytic 1,4 conjugate additions using unprotected and protected maleimides. Special attention has been paid classifying the types of nucleophiles as well as catalysts employed for this asymmetric transformation along with substrate scope, limitation, mechanism, and synthetic utilities for each reaction. Knowing the versatility of maleimides, this review will encourage active researchers around the globe to put more efforts on the development of new methodologies including asymmetric photo redox catalysis for further functionalization of maleimides.