bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Cancer‐Related Trauma and Growth in Caregivers Across the Lifespan
Authors: Benedict Erinne , Landa Fruma , Shaykevich Aaron , Patton Caroline Delbourgo , Mitchell Hannah‐Rose 
Published: January 2025

ABSTRACTBackgroundFamily members can be required to take on the role of “caregiver” at any stage of life, causing disruption and psychological distress. This review sought to describe the traumatic impact (i.e., posttraumatic stress symptoms (PTSS) and posttraumatic growth (PTG) of cancer caregiving across the lifespan.AimsThis systematic review characterizes the current literature on cancer caregiver PTSS and PTG through a developmental lens with respect to caregiver age and their relationship to the patient.MethodsThree electronic databases (PubMed/MEDLINE, Embase, and PsycInfo) were searched for relevant studies using a combination of controlled vocabulary and text words. Studies were limited to English‐language only articles, but not limited by geography or publication date. A literature review management tool, Covidence, was used to screen for article eligibility as well as for data extraction and article quality assessment.ResultsA final total of 275 studies underwent data extraction and quality assessment. Studies indicated that at all ages, caregivers experience PTSS. A gap in the literature was identified for child (< 18) and older adult (65+) caregivers. At other ages, most studies found elevated PTG in caregivers. Small variations of number of studies finding PTSS and PTG were found across age ranges.ConclusionsPosttraumatic stress and growth appear to be experienced across the lifespan. However certain age groups are under‐researched. Few studies focus on younger or older caregivers, especially in respect to PTG. There is a crucial need for studies in caregivers, particularly in these groups to fully address and support their unique caregiving needs and current population‐based research does not attempt to depict the proportion of cancer caregivers at different developmental stages.
Course of Mental Disorders in Early Cancer Survivorship in Relation to Socioeconomic Status: A Multi‐Center Prospective Longitudinal Study (LUPE)
Authors: Springer Franziska , Goerling Ute , Zimmermann Tanja , Ernst Jochen , Engel Christoph , Hermann Myriel , Esser Peter , Hornemann Beate , Keilholz Ulrich , Lordick Florian , Knesebeck Olaf von dem , Kissane David , Mehnert‐Theuerkauf Anja 
Published: January 2025

ABSTRACTObjectiveIndividuals with low socioeconomic status (SES) exhibit higher rates of mental disorders; however, data in oncological populations are insufficient. This study investigated the course of DSM‐5 mental disorders in cancer patients, stratified by SES, over a period of 1.5 years following initial cancer diagnosis.MethodsThis multi‐center prospective longitudinal study assessed cancer patients within two months of cancer diagnosis (t1), and at 6‐, 12‐, and 18‐month follow‐up (t2–t4) using the SCID‐5 interview for mental disorders based on DSM‐5 criteria. Chi‐square‐tests were tested for frequency changes over time. A generalized linear mixed model (GLMM) was applied with fixed effects for SES and time on mental disorders.ResultsOut of 1030 patients with a SCID‐5 at baseline (53.2% men, 60 years), 821, 719 and 654 participated at respective follow‐ups. The most common diagnoses were skin and prostate cancer. Point prevalence of mental disorders was 20.9% at baseline, decreasing to 18.2%, 14.6%, and 15.0% (t2–t4; χ2 (3) = 15.3, p = 0.002). Patients with low SES consistently showed highest prevalence rates, whereas patients with high SES showed decreasing rates of mental disorders over time, with a main effect of time (χ2 (3) = 19.9, p < 0.001) and SES (χ2 (2) = 8.8, p = 0.01) in the GLMM. Two thirds never met diagnostic criteria for a mental disorder. Sensitivity analysis among study completers (n = 592) revealed a similar pattern to the main analysis.ConclusionsCancer patients with low SES exhibit impaired coping with cancer‐related stressors, increasing their risk for mental disorders. Social disparities affect physical and mental health, possibly via health behavior or health literacy, and need to be addressed by tailored survivorship care planning.
Epidemiological Characteristics of Pathogens in Bronchoalveolar Lavage Fluid in Children With Lower Respiratory Tract Infections: A Retrospective Analysis
Authors: Zhang Lei , Wang Yiheng , Zheng Yu , Zhao Yong , Dai Hongchen , Li Guitao , Zhu Ying 
Published: January 2025

ABSTRACTBackgroundThe COVID‐19 pandemic has significantly altered the etiological spectrum and epidemiological characteristics of pediatric respiratory diseases, and a profound understanding of these changes is crucial for guiding clinical treatment. The purpose of this study is to analyze the etiological patterns and epidemiological features of pathogens in bronchoalveolar lavage fluid (BALF) from children with pediatric lower respiratory tract infections (LRTIs) after the COVID‐19 pandemic, with the aim of providing effective therapeutic evidence for clinical practice.MethodsThis study enrolled pediatric patients diagnosed with LRTIs who were treated and underwent BALF pathogen detection at our hospital from June 1, 2023, to June 1, 2024. Demographic characteristics and clinical outcomes of the patients, along with the results of BALF pathogen detection, were meticulously collected and subsequently analyzed.ResultsA total of 682 children with LRTIs who underwent BALF examinations were included in this study. In pediatric LRTIs, winter was the peak season for disease onset. Regarding diagnostic categories, lobar pneumonia and bronchopneumonia were the most common diseases, representing 62.5% and 27.1% of diagnosed cases, respectively. The vast majority of pediatric patients showed complete recovery in clinical symptoms or imaging findings within 2 weeks after receiving treatment. The BALF examination results revealed that the five most frequently identified pathogens were Mycoplasma pneumoniae (83.1%), followed by Streptococcus pneumoniae (21.3%), Haemophilus influenzae (16.6%), Staphylococcus aureus (11.7%), and Human Respiratory Syncytial Virus (11.3%).ConclusionThe etiological spectrum of pediatric LRTIs is complex, necessitating targeted clinical treatments tailored to the predominant pathogens.
Zika and Dengue Virus Autoimmunity: An Overview of Related Disorders and Their Potential Mechanisms
Authors: Zhou Feifan , Xu Yuanze , Liu Xing , Xu Yan , Wang Yan , Jiang Donghui , Du Pengfei 
Published: January 2025

ABSTRACTZika virus (ZIKV) and dengue virus (DENV) are two major mosquito‐borne flaviviruses that pose a significant threat to the global public health system, particularly in tropical regions. The clinical outcomes related to these viral pathogens can vary from self‐limiting asymptomatic infections to various forms of life‐threatening pathological conditions such as haemorrhagic disorders. In addition to the direct effects of the viral pathogens, immune processes play also a significant function in the development of diseases mediated by ZIKV and DENV. Studing these processes is important for developing safer vaccines and targeted therapeutic strategies. These viruses have been reported to trigger various autoimmune disorders affecting different parts of human organ systems. It also has been shown that preexisting immunity to ZIKV or DENV can impact the outcome of subsequent infections caused by another virus. ZIKV and DENV infection can promote the development of autoimmune disorders by different mechanisms, such as molecular mimicry and autoantibody formation. The present review provides an overview of various autoimmune disorders associated with ZIKV and DENV infection and their potential underlying mechanisms.
Toward the Optimization of a Perovskite‐Based Room Temperature Ozone Sensor: A Multifaceted Approach in Pursuit of Sensitivity, Stability, and Understanding of Mechanism
Authors: Argyrou Aikaterini , Giappa Rafaela Maria , Gagaoudakis Emmanouil , Binas Vassilios , Remediakis Ioannis , Brintakis Konstantinos , Kostopoulou Athanasia , Stratakis Emmanuel 
Published: January 2025

AbstractMetal halide perovskites (MHPs) have attracted significant attention owing to their simple manufacturing process and unique optoelectronic properties. Their reversible electrical or optical property changes in response to oxidizing or reducing environments make them prospective materials for gas detection technologies. Despite advancements in perovskite‐based sensor research, the mechanisms behind perovskite‐gas interactions, vital for sensor performance, are still inconclusive. This work presents the first evaluation of the sensing performance and long‐term stability of MHPs, considering factors such as halide composition variation and Mn doping levels. The research reveals a clear correlation between halide composition and sensing behavior, with Br‐rich sensors displaying a p‐type response to O3 gas, while Cl‐rich counterparts exhibit n‐type sensing behavior. Notably, Mn‐doping significantly enhances O3 sensing performance by facilitating the gas adsorption process, as supported by both atomistic simulations and experimental evidence. Long‐term evaluation of the sensors provides valuable insights into evolving sensing behaviors, highlighting the impact of dynamic instabilities over time. Overall, this research offers insights into optimal halide combination and Mn‐doping levels, representing a significant step forward in engineering room temperature perovskite‐based gas sensors that are not only low‐cost and high‐performing but also durable, marking a new era in sensor technology.
In Situ Proefferocytosis Microspheres as Macrophage Polarity Converters Accelerate Osteoarthritis Treatment
Authors: Wang Yong , Pu Chaoyu , Han Zeyu , Du Yawei , Chen Liang , Huang Yanran , Luo Yue , Xiang Chao , He Jiangtao , Chen Lu , Cui Wenguo , Jiang Ke , Li Yuling 
Published: January 2025

AbstractEfferocytosis in macrophages typically engages an anti‐inflammatory positive feedback regulatory mechanism. In osteoarthritis (OA), characterized by imbalanced inflammatory homeostasis, the proinflammatory state of macrophages in the immune microenvironment can be reversed through enhanced efferocytosis. This study develops an in situ proefferocytosis hydrogel microsphere (macrophage polarity converter, H‐C@IL) for OA treatment. Immunoliposomes (IL), CD16/32 antibody‐modified clodronate liposomes, are initially prepared using the Re‐emulsion method. Then, the IL is loaded into CCL19‐modified HAMA microspheres through microfluidic technology. In vitro, H‐C@IL can specifically recruit M0 and M1 macrophages via CCL19, induce apoptosis in M1 macrophages through secondary targeting with IL, and provide “Find/Eat‐me” signals to enhance in situ efferocytosis. Additionally, it promotes macrophage polarization toward the M2 phenotype. In vivo, behavioral, imaging, and histological analyses demonstrate that H‐C@IL effectively facilitates macrophage polarization toward M2, inhibits inflammation, and promotes cartilage regeneration. Mechanistically, H‐C@IL enhances efferocytosis by activating proteins such as PROS1 and TIMD4 in M0 macrophages. Concurrently, signaling pathways, including PQLC2‐Arg‐Rac1 and Pbx1/IL‐10, are activated to drive the polarization of macrophages from M0 to M2. In summary, H‐C@IL promotes M0 macrophage efferocytosis in situ, facilitates macrophage polarization toward M2, restores inflammatory homeostasis, and promotes cartilage regeneration, offering a comprehensive treatment strategy for OA.
Chemical Vapor Deposition Growth of 2D Nonlayered CuInSe2 for Vacancy‐Assisted Broadband Photodetection
Authors: Wang Yuying , Xue Qichao , Zhang Jincheng , Wang Yu , Wang Jiayang , Li Guiying , Yang Chenying , Shao Yuchuan , Liang Tao 
Published: January 2025

AbstractThe properties and device applications of 2D semiconductors are highly sensitive to intrinsic structural defects due to their ultrathin nature. CuInSe2 (CIS) materials own excellent optoelectronic properties and ordered copper vacancies, making them widely applicable in photovoltaic and photodetection fields. However, the synthesis of 2D CIS nanoflakes remains challenging due to the nonlayered structure, multielement composition, and the competitive growth of various by‐products, which further hinders the exploration of vacancy‐related optoelectronic devices. Here, 2D CIS nanoflakes are successfully synthesized using a molecular sieve‐assisted chemical vapor deposition process. The anisotropic van der Waals growth with well‐defined exposed facets is closely associated with the presence of the molecular sieve. Electron microscopy techniques reveal the ordered copper vacancies within the as‐grown 2D crystals, extending the optical absorption to the near‐infrared region. Consequently, 2D CIS nanoflake‐based photodetectors exhibit broadband photodetection capabilities (470 to 1550 nm) and exceptional performance, such as a high responsivity of 11 A W−1, an external quantum efficiency (EQE) of 2143%, and a fast response speed of ≈46.5 ms under an incident wavelength of 637 nm, highlighting their promising potential in next‐generation optoelectronics.
Functional Injectable Hydrogel for Bone Regeneration: Regulation of the circSRPK1/miR‐320a Axis and Targeting Multiple Osteogenic Pathways via CDH2 and Osterix Genes
Authors: Wang Yingjie , Mao Xiaowei , Li Dandan , Zhao Yanran , Yang Xingdong , Zheng Zhibo , Liu Xudong , Lv Zehui , Cai Xuejie , Weng Xisheng , Zhang Hongyu , Feng Bin 
Published: January 2025

ABSTRACTHydrogels loaded with microRNA (miRNA) have shown promise in bone‐defect repair. Here, we present the first report of miRNA‐loaded hydrogels containing bioactivities to treat steroid‐induced osteonecrosis of the femoral head (SONFH), based on the mechanism of competing endogenous RNAs. Transcriptome sequencing of human bone marrow mesenchymal stem cells (HBMSCs) extracted from the proximal femoral bone marrow and subsequent functional assays revealed that the circSRPK1/miR‐320a axis promotes HBMSCs osteogenic differentiation. By incorporating antagomir‐320a (a miR‐320a inhibitor) encapsulated in liposomes into injectable hyaluronic acid (HA) hydrogels, we constructed an injectable hydrogel, HA@antagomir‐320a. This hydrogel demonstrated exceptional osteogenic properties, targeting multiple osteogenic pathways via CDH2 and Osterix and exhibited excellent in vitro biocompatibility. In vivo, it substantially enhanced bone formation in the osteonecrotic area of the femoral head. This injectable HA@antagomir‐320a hydrogel, which exhibited exceptional biocompatibility and osteogenic properties in vivo and in vitro, offers a promising and minimally invasive solution for the treatment of SONFH.
CRISPR‐mediated mutation of cytokinin signaling genes (SlHP2 and SlHP3) in tomato: Morphological, physiological, and molecular characterization
Authors: Aydin Abdullah , Yerlikaya Bayram Ali , Yerlikaya Seher , Yilmaz Nisa Nur , Kavas Musa 
Published: January 2025

AbstractSynergistic and antagonistic relationships between cytokinins and other plant growth regulators are important in response to changing environmental conditions. Our study aimed to determine the functions of SlHP2 and SlHP3, two members of cytokinin signaling in tomato, in drought stress response using CRISPR/Cas9‐mediated mutagenesis. Ten distinct genome‐edited lines were generated via Agrobacterium tumefaciens‐mediated gene transfer and confirmed through Sanger sequencing. Stress experiments were conducted with two of these lines (slhp2,3‐10 and slhp2,3‐11), which harbored homozygous mutations in both genes. The responses of two lines carrying homozygous mutations in both genes under polyethylene glycol (PEG)‐induced stress were examined using morphological, physiological, biochemical, and molecular methods. The genome‐edited lines demonstrated enhanced water retention, reduced stomatal density, and less oxidative damage compared to the wild‐type plants under PEG‐induced stress. Moreover, the slhp2,3 double mutant plants exhibited improved root growth, showcasing their superior drought tolerance over wild‐type plants by accessing deeper water sources and maintaining hydration in water‐limited environments. To investigate the involvement of cytokinin signaling regulators and genes associated with stomatal formation and differentiation, the expression of genes (Speechless [SPCH], FAMA, MUTE, TMM, HB25, HB31, RR6, RR7, and Solyc02g080860) was assessed. The results revealed that all regulators were downregulated, with SPCH, TMM, RR7, and RR6 showing significant reductions under PEG‐induced stress. These results emphasize the promise of utilizing CRISPR/Cas9 to target cytokinin signaling pathways, enhancing drought tolerance in tomatoes through improvements in water retention and root growth, along with a reduction in stomatal density and malondialdehyde content.
Ecosystem Services in Drying River Networks: A Meta‐Ecosystem Conceptual Model
Authors: Pérez‐Silos Ignacio , Barquín José , Datry Thibault 
Published: January 2025

ABSTRACTAll river networks are virtually prone to drying, which is dramatically increasing in space and time. This threatens the functions and ecosystem services (ES) rivers provide to societies. Here, we introduce a new conceptual model of the provision of ES in drying river networks (DRN), situating drying as a pivotal element of every river network. Based on a meta‐ecosystem perspective, we contend that ES provision is determined in DRN by the exchange of abiotic and biotic flows between terrestrial and aquatic ecosystems in the catchment. Specifically, we highlight three main components of the ecosystem involved: the intensity of abiotic flows, biodiversity patterns, and ecosystem functioning rates. How they vary in space and time due to changes in the hydrological connectivity in catchment‐DRN determines the pattern of ES provision along the DRN. Although drying events are the cause of the great diversity of services naturally provided by DRN, we must perceive their anthropogenic increase as a major socio‐ecological risk factor.
MHD tri‐hybrid nanofluid blood flow in a porous cylinder: Insights from fractional relaxation modeling with thermal radiation and slip velocity boundary condition
Authors: Omama Mohamed , Arafa Ayman A. , Elsaid Ahmed , Zahra Waheed K. 
Published: January 2025

AbstractThe study of flow through cylindrical structures holds significant importance in fields such as biomedical engineering, petroleum extraction, and industrial processes. In particular, understanding blood flow in cylindrical geometries that mimic small arteries is crucial for advancing cardiovascular health, treatment methods, and drug delivery systems. Traditional models often fail to capture the complex nonlocal and memory effects inherent in blood flow dynamics, limiting their accuracy in predicting heat transfer and flow characteristics essential for medical applications. This study addresses these limitations by developing an innovative fractional‐order magnetohydrodynamic (MHD) model for blood flow using a tri‐hybrid nanofluid composed of , , and . The model uniquely integrates boundary slip velocity effects within the fractional Maxwell rheology framework and employs the fractional Cattaneo bioheat transfer model, applied to a porous cylindrical structure. The mathematical formulation is based on the Caputo approach to model fractional‐order time derivatives in both the thermal and momentum equations. Numerical solutions are obtained using finite difference techniques, incorporating L1 and L2 approximations for the Caputo fractional derivatives. The study investigates the effects of fractional orders and , along with parameters such as wall slip velocity and thermal radiation, on velocity, temperature, skin friction, and Nusselt number. Results indicate that the tri‐hybrid nanofluid achieves up to a 10% enhancement in heat transfer compared to blood or di‐hybrid nanofluids, also exhibiting 25%–40% lower skin friction. Furthermore, the fractional‐order models offer more realistic and stable predictions across flow conditions. The fractional Maxwell model shows gradual velocity and friction responses, while the fractional Cattaneo model yields lower heat transfer rates than its classical counterpart. By incorporating fractional calculus, the model improves simulation of complex transport in small arteries, aiding development of better cardiovascular treatments.
Non-trivial Self-organised Floor Plans: An Optimisation Strategy
Authors: Carta Silvio , Shekhawat Krishnendra , Ambrosini Luciano , Turchi Tommaso , Vidal Miguel 
Published: January 2025

Abstract
We present a novel workflow where non-rectangular floor plans (NRFPs), namely plans with at least one concave corner, are self-generated using a model that directly encodes key optimisation factors on spatial quality and energy consumption, with non-rectangular building envelopes. The modelling considers a number of key factors including architectural and urban quality, net zero factors and adherence to general residents’ feedback from previous studies. We provide evidence that the proposed workflow outperforms a number of optimisation solvers generally used in computational design, in those cases where solar radiation is most needed. Our study combines a syntactic approach with a computational one with a novel workflow to encode tangible and intangible factors to improve a specific class of non-trivial floor plans (L-shaped).
App-basierte Anpassung des Cochlea-Implantats durch den Patienten
Authors: Büchner Andreas 
Published: January 2025

Zusammenfassung
Heute ist die Versorgung hochgradig Schwerhöriger und ertaubter Patienten mit einem Cochlea-Implantat Routine. Allein an der Medizinischen Hochschule in Hannover werden pro Jahr mehr als 500 Patienten mit einem Cochlea-Implantat (CI) versorgt, d. h. der Patienten-Pool der CI-versorgenden Zentren steigt jedes Jahr signifikant. Weltweit sind mittlerweile etwa 1 Mio. Patienten mit einem derartigen System versorgt, allein in Deutschland schätzt man die Zahl der Versorgten auf über 60.000. Es versteht sich von selbst, dass bei der großen Zahl an CI-Patienten eine zentrale jährliche Routinekontrolle für alle Patienten auf Dauer in den Implantationszentren nicht zu leisten ist. Auch möchten viele Patienten Anreisewege und Zeitaufwand reduzieren, ohne jedoch auf die Kompetenz großer Kliniken verzichten zu müssen. Zur gleichen Zeit steigt der Kostendruck durch die Krankenkassen, und es entsteht die Notwendigkeit, Behandlungen effizienter zu gestalten bei gleicher oder gar besserer Versorgungsqualität. Hier kann und wird die Telemedizin in Form von App-basierter Nachsorge in Zukunft ihren Beitrag leisten.