bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advancement in the Inhibition of Triple-negative Breast Cancer by N-heterocycles
Authors: Choudhury Badruzzaman , Chanda Kaushik 
Published: April 2023

Abstract:
Despite the substantial progress that has been made in cancer therapy over the past few decades, there has
been a discernible rise in the number of reported instances of carcinoma over the past few decades. Breast cancer especially
triple-negative breast cancer (TNBC), being the most common cancer found in females account for extensive
research. This type of cancer, which is responsible for more than 15% to 20% of all breast cancers, is particularly interesting
for research since it is difficult to treat due to its poor response to treatment and extremely aggressive nature. In
clinical practice, triple-negative breast cancer is characterized by a relatively high risk of disease recurrence and distant
metastasis, as well as a poor prognosis regarding overall survival. The goal of this review is to provide the recent advancement
of the therapeutic potential of N-heterocycles covering in vitro and in vivo activities for the treatment of
triple-negative breast cancer.
Some Wild Mushrooms with High Antioxidant Capacity Exhibit Potent Anticancer
Activity on Cancer Cells using the Apoptotic and Antimigration Cell Death Mechanisms
Authors: Şebin Murat , Yılmaz Necmettin , Aydın Ali 
Published: April 2023

Aim:
This study aims to provide in vitro experimental evidence that wild mushrooms have the potential to
be used as a pharmaceutical that could be effective against various types of cancer.

Background:
Throughout human history, besides food, traditional medicine and natural poisons obtained from mushrooms have been used for the treatment of many diseases. Clearly, edible and medicinal mushroom preparations have
beneficial health effects without the known severe adverse side effects.

Objectives:
This study was designed to reveal the cell growth inhibitory potential of five different edible mushrooms
and the biological activity of Lactarius zonarius was shown here for the first time.

Methods:
The mushrooms fruiting bodies were dried and powdered then extracted with hexane, ethyl acetate, and
methanol. The mushroom extracts were screened for possible antioxidant activities by the free radical scavenging
activity (DPPH) method. Antiproliferative activity and cytotoxicity of the extracts were investigated in vitro on A549
(human lung carcinoma), HeLa (human cervix carcinoma), HT29 (human colon carcinoma), Hep3B (human hepatoma), MCF7 (human breast cancer), FL (human amnion cells), and Beas2B (normal human cells) cells lines by using
MTT cell proliferation assay, lactate dehydrogenase (LDH) assay, DNA degradation, TUNEL, and cell migration
assay.

Results:
Results: Using proliferation, cytotoxicity, DNA degradation, TUNEL, and migration assay, we displayed that hexane,
ethyl acetate, and methanol extracts of the Lactarius zonarius, Laetiporus sulphureus, Pholiota adiposa, Polyporus
squamosus, and Ramaria flava were effective on the cells even so at low doses (< 45.0 - 99.6 μg/mL) by acting in a
way that represses migration, as a negative inducer of apoptosis. It was also demonstrated that mushroom extracts with
high antioxidant effect have within the acceptable cytotoxic activity of 20%-30% on the cell membrane at concentrations
higher than 60 μg/mL.

Conclusion:
Overall, all of the mushroom extracts with high antioxidant effects had strong antiproliferative activity
and low toxicity for cells. These findings, at least, highlight that these mushroom extracts c
Clinical Benefits of Therapeutic Interventions Targeting Mitochondria in
Parkinson’s Disease Patients
Authors: Ciocca Matteo , Pizzamiglio Chiara 
Published: April 2023

Abstract:
Parkinson’s disease is the second most common neurodegenerative disease. Mitochondrial
dysfunction has been associated with neurodegeneration in Parkinson’s disease, and several treatments
targeting mitochondria have been tested in these patients to delay disease progression and tackle disease
symptoms. Herein, we review available data from randomised, double-blind clinical studies that
have investigated the role of compounds targeting mitochondria in idiopathic Parkinson’s disease patients,
with a view of providing patients and clinicians with a comprehensive and practical paper that
can inform therapeutic interventions in this group of people. A total of 9 compounds have been tested
in randomized clinical trials, but only exenatide has shown some promising neuroprotective and symptomatic
effects. However, whether this evidence can be translated into daily clinical practice still needs to
be confirmed. In conclusion, targeting mitochondrial dysfunction in Parkinson’s disease is a promising
therapeutic approach, although only one compound has shown a positive effect on Parkinson’s disease
progression and symptoms. New compounds have been investigated in animal models, and their efficacy
needs to be confirmed in humans through robust, randomised, double-blind clinical trials.
Circulating MicroRNAs: Diagnostic Value as Biomarkers in the Detection
of Non-alcoholic Fatty Liver Diseases and Hepatocellular Carcinoma
Authors: Rana Minakshi , Saini Manisha , Das Rina , Gupta Sumeet , Joshi Tanishq , Mehta Dinesh Kumar 
Published: April 2023

Abstract:
Non-alcoholic fatty liver disease (NAFLD), a metabolic-related disorder, is the most common cause of chronic liver disease which, if left untreated, can progress from simple steatosis to advanced fibrosis and eventually cirrhosis or hepatocellular carcinoma, which is the leading cause of hepatic damage globally. Currently available diagnostic modalities for NAFLD and hepa-tocellular carcinoma are mostly invasive and of limited precision. A liver biopsy is the most wide-ly used diagnostic tool for hepatic disease. But due to its invasive procedure, it is not practicable for mass screening. Thus, noninvasive biomarkers are needed to diagnose NAFLD and HCC, monitor disease progression, and determine treatment response. Various studies indicated that se-rum miRNAs could serve as noninvasive biomarkers for both NAFLD and HCC diagnosis because of their association with different histological features of the disease. Although microRNAs are promising and clinically useful biomarkers for hepatic diseases, larger standardization procedures and studies are still required.
PREDIKSI POLA SEBARAN PLUME RISE PADA VARIASI KECEPATAN EMISI GAS BUANG CHIMNEY DENGAN SIMULASI KOMPUTER
Authors: Shobakh Muhammad Nur , Widodo Agung Sugeng 
Published: April 2023

One of the most significant current issues that endangers environment is air pollution from industrial chimney emissions. In certain condition, the mathematical models to analyze this problem is the Gaussian Plume Model (GPM), which is a model of air pollutant distribution that takes place under constant conditions and is based on the Gaussian distribution. This model was developed based on the diffusion equation to determine the pollutant concentration from a single point source located at a certain altitude and terrain. The aim of this research was to investigate Simulating the dispersion pattern of pollutant gas plume rise from the chimney to the environment using Ansys Workbench software, analyze the shape of the plume rise dispersion pattern and investigate factors influence the plume rise in the chimney. The results showed that the plume rise dispersion pattern that occurred in this study is lofting. The higher the velocity of exhaust emissions coming out of the chimney, the higher the plume rise that occurs into the atmosphere. The factors that can affect the plume rise dispersion pattern in the chimney are the wind speed factors, the atmospheric air temperature factors, and the air stability factors.
Telehealth Challenges for California Rural Hospitals in Reaching Latino Populations During COVID-19
Authors: Mauricio Noemi , Newhart Glen , Herber Steven , Ahumada-Newhart Veronica 
Published: April 2023

Background
Rural and remote communities were especially vulnerable to the COVID-19 pandemic due to the availability and capacity of rural health services. Research has found that key issues surrounded (1) the lack of staff, (2) the need for coordinated health services, and (3) operational and facility issues. Similarly, research also confirms that irrespective of hospital capacity issues existing during crisis, compared to urban communities, rural communities typically face poorer access to health services. Telehealth programs have long held promise for addressing health disparities perpetuated by inadequate health care access. In response to the current COVID-19 pandemic, Adventist Health Saint Helena Hospital, a rural hospital in northern California, urgently worked to expand telehealth services. However, as Adventist Health Saint Helena Hospital is the longest-serving rural hospital in the state of California, administrators were also able to draw on experiences from the pandemic of 1918/1919. Understanding their historically rural and heavily Latino populations, their telehealth approach was coupled with cultural approaches for prioritizing socially responsive and equitable access to health services.

Objective
This study aimed to present one rural community’s holistic sociotechnical response to COVID-19 in redesigning their health care delivery approach. Redesign efforts included the expansion of digital health services coupled with county-wide collaborations for nondigital mobile health centers, testing, and vaccination clinics to meet the needs of those with limited digital access and language barriers.

Methods
We present data on telehealth services for maintaining critical care services and a framework on the feasibility of private-public partnerships to address COVID-19 challenges.

Results
In this paper, we provide a critical review of how a rural hospital adapted its health care approach to incorporate telehealth services and distance services to meet the needs of a diverse population.

Conclusions
This paper contributes empirical data on how rural communities can use telehealth technologies and community partnerships for a holistic community approach to meet health needs during a natural disaster.

Conflicts of Interest
None declared.
Development and Validation of HPLC–Photodiode Array Method for Detecting Steroids in Skin Whitening Products Simultaneously
Authors: Yustina Yustina , Sophian Alfi 
Published: April 2023

Since steroids are prohibited to be present in cosmetic products, thus an identification of these outlawed compounds intentionally incorporated in skin whitening product is enough for market surveillance purpose. Simultaneous method for detecting prednisone (PRN), triamcinolone acetonide (TCA), hydrocortisone acetate (HCA), clobetasole propionate (CBP), and mometasone furoate (MTF) has not been developed until now. The goals of this study were to develop and to validate for screening these five steroid compounds in cosmetic product by using reverse phase (RP) high-performance liquid chromatography (HPLC) equipped with photo diode array (PDA) detector. Validation method was applied including the system suitability test, determination of specificity and selectivity, and determination of detection limit. . In optimization step, we succeeded distinguish and identify five steroid compounds with different retention time.The retention times of PRN, TCA, HCA, CBP and MTF were detected at 3.267, 4.260, 4.910, 15.360, and 16.707 min, respectively. The method performed good selectivity with resolution more than 1.5. While for determination of limit of detection (LOD) was carried out by calibration curve approach over the range 0.5-5 µg/ml and resulted in LOD value for PRN, TCA, HCA, CBP and MTF were 7.20, 8.85, 8.17, 9.30, and 8.42 µg/g, respectively. The developed method can be applied for routine analysis of PRN, TCA, HCA, CBP and MTF in various type of cosmetic products.
Efecto de la fuente de selenio en el comportamiento productivo, contenido de selenio en suero y músculo, y nivel sérico de albúmina, α-, β- y ∂-globulinas en ovinos Pelibuey
Authors: Cárdenas-Ramírez Lino Rigoberto , Sánchez-Del Real Carlos , Ruíz-Flores Agustín , Pérez-Hernández Gabriela , López-Ordaz Reyes , Vite-Cristóbal Claudio , López Ordaz Rufino 
Published: April 2023

El objetivo fue comparar los efectos de selenito de sodio (SS) y Sel-Plex® (SP) en el consumo de materia seca (CMS), ganancia diaria de peso (GDP), conversión alimenticia (CA), rendimiento de canales, Se en suero, músculos, albúmina, y globulinas en corderos Pelibuey. Cincuenta animales (PV=23.0 ± 1.1 kg; de 5 a 6 meses) se estratificaron y aleatoriamente asignaron a uno de cinco tratamientos (n=10): 1) Dieta basal, C); 2) C + 0.30 mg kg-1 MS de SS, 30SS; 3) C + 0.90 mg kg-1 MS de SS, 90SS; 4) C + 0.30 mg kg-1 MS de SP, 30SP; y 5) C + 0.90 mg kg-1 MS de SP, 90SP. No hubo efectos (P>0.05) en CMS; mientras que 90SP y 30SS mostraron GDP mayores (293 y 260 vs 245, 243, y 230 g día-1; P<0.05) en comparación con los demás tratamientos. La CA fue mejor para 90SP y C. Los PV finales, rendimientos de canales y la grasa dorsal no se afectaron (P>0.05). En Longissimus dorsi, 30SP incrementó (P<0.05) el Se con respecto a 90SP y C, y fue similar con 30SS y 90SS. No hubo efecto (P>0.05) en Gluteus maximus y Musculus deltoideus. La albúmina fue mayor con 30SP y 90SS; mientras que α-globulina fue mayor con 30SS y 90SP. En conclusión, 0.90 mg de SP mejoró la GDP y CA. Selenito y SP aumentaron el Se en suero hasta 0.30, y disminuyó con 0.90 mg por kilo de SP. En Longissimus dorsi, el Se se mejoró en 30SP con respecto 90SP y el C y no fue similar a 90SS y 30SS. El Se orgánico de 90SP mejoró el nivel de albúmina y α-globulinas.
Estructura y variabilidad genética del bisonte americano (Bison bison) en México
Authors: Domínguez-Viveros Joel , Aguilar-Palma Guadalupe Nelson , Villa-Angulo Rafael , Hernández-Rodríguez Nancy , Pérez-Cantú José Manuel , Moir Flora , Calderón-Domínguez Pedro 
Published: April 2023

Los objetivos fueron analizar la estructura y variabilidad genética del bisonte americano con marcadores genéticos de tipo SNP. Se muestrearon 174 bisontes y se analizaron 42,366 SNP distribuidos en los 29 cromosomas. Se estimó la heterocigosis esperada (He) y observada (Ho), contenido de información polimórfica (CIP), índice de fijación (FIS), índice de Shannon (IS), desequilibrio de ligamiento y relación de parentesco (Rij; %), así como el tamaño efectivo de población (Ne). Se realizó un análisis de estructura genética para inferir cuántas líneas o genomas (k) definen la población. Se identificó y seleccionó un panel con 2,135 SNP polimórficos, con un promedio de 74 SNP por cromosoma. En el proceso de exclusión, 84.5 % fueron monomórficos, 8.5 % con porcentaje de usables menor a 90 %, 6.3 % con frecuencia del alelo menor inferior a 0.01 y 0.70 % por desequilibrio Hardy-Weinberg (P<0.05). Las estimaciones de IS, Ho, He, FIS y CIP fueron de 0.30, 0.187, 0.182, -0.029 y 0.152, respectivamente. Se generaron 15,051 estimaciones de Rij, el valor promedio de éstas fue 7.6 %, y el 45.1 % de ellas fue igual a cero. El Ne fue de 12.5, señalando un posible incremento de consanguinidad por generación de 4 %. Se identificaron tres líneas genéticas, con proporciones de 0.730, 0.157 y 0.113; dado el origen de la población, se asocian a selección natural o deriva genética. La variabilidad genética, así como los niveles de la Rij, se deben de considerar en esquemas de conservación.
Autocategorização racial e habilidades sociais em crianças brasileiras: uma avaliação multi-informante
Authors: Freitas Lucas Cordeiro , Fernandes Sheyla Christine Santos , Porfírio Jonas Caio Costa 
Published: April 2023

Este estudo objetivou identificar diferenças e semelhanças nas habilidades sociais de crianças de uma escola pública autodeclaradas negras e brancas. Participaram 72 alunos do ensino fundamental (42 autocategorizados como brancos e 30 como negros), bem como seus professores e pais. Foram utilizados dois instrumentos de autocategorização racial e três escalas do Social Skills Rating System (SSRS) para avaliar as habilidades sociais. Na amostra geral, as crianças negras relataram um repertório mais elaborado de empatia/afetividade e de assertividade. Por outro lado, crianças com tonalidades de pele mais claras relataram maior responsabilidade. Subgrupos diferenciados por raça e sexo também apresentaram diferenças em algumas habilidades sociais. Os resultados foram discutidos considerando a influência de variáveis pessoais e fatores contextuais.
Assessment for the installation of a solar PV system in Pakistan for a sustainable environmental and economic development
Authors: Awais Muhammad , Rehan Muhammad , Ahn Seung Kyu , Kim Kyungsoo , Gwak Jihye , Kihwan Kim , Ahn Sejin , Eo Young-Joo 
Published: April 2023

In this study, a photovoltaic system with RETScreen software is simulated to see its economic and environmental feasibility in the one of the remote locations in Pakistan. Our proposed photovoltaics power system is installed south Asia: particularly, Pakistan which receives a high amount of solar irradiance throughout the year. The proposed location has an electricity demand of 28.70 MWh/month, and our simulated PV system generates 31 MWh/month which is more than the amount of required electricity demand. The 25 years long life project will have energy payback time of 7.4 years and the net greenhouse gas (GHG) emission reduction will be 3,942 tCO2 for the whole project life. These results summarize that installation of this solar power system is not only economically feasible, but also reduces the emission of greenhouse gases in that selected location.
KEWAJIBAN MASYARAKAT DALAM PEMELIHARAAN KELESTARIAN LINGKUNGAN HIDUP MELALUI PENGELOLAAN SAMPAH BERBASIS MASYARAKAT
Authors: Purwendah Elly Kristiani , Rusito  , Periani Aniek 
Published: April 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis bagaimana terkait pengelolaan sampah, mengetahui dan menganalisis bagaimana peran bank sampah dalam pengelolaan sampah dan mengetahui dan menganalisa bagaimana pengelolaan sampah yang berbasis masyarakat. Jenis penelitian yang digunakan adalah penelitian hukum normatif. Data yang diperoleh dari penelitian ini data sekunder yang diperoleh melalui studi kepustakaan, kemudian data yang diperoleh dianalisis secara yuridis kualitatif melalui pendekatan perundang-undangan dan konseptual. Hasil penelitian ini menunjukkan bahwa (1) Sistem pengelolaan sampah merupakan proses pengelolaan sampah yang meliputi 5 (lima) aspek yaitu aspek kelembagaan; pembiayaaan; pengaturan; teknik operasional; dan peran serta masyarakat, (2) Bank Sampah dalam pelaksanaanya dapat mengurangi tingginya angka sampah di masyarakat dan di tempat pembuangan akhir (TPA). Sehingga, melalui Bank Sampah menjadi salah satu alternatif solusi bagi pemerintah maupun masyarakat dalam mengurangi terus meningkatnya volume sampah. (3) Pengelolaan sampah berbasis masyarakat sebagai suatu pendekatan pengelolaan sampah yang didasarkan pada partisipasi aktif masyarakat. Pengelolaan lingkungan hidup memerlukan adanya fasilitasi dan implementasi upaya berbasis masyarakat sebagai suatu strategi pemberdayaan dan peningkatan akses mereka kepada sumber daya lingkungan hidup.
Social and Psychological Problems of families of Children with Cerebral Palsy: A study applied to the Palestine Future Foundation in the Gaza Strip
Authors: Kerret Zyad 
Published: April 2023

The study aimed to identify the social and psychological problems facing the families of children with cerebral palsy, and the researcher used the social survey methodology by selecting a simple random sample of the families of children with cerebral palsy in the Palestine Future Foundation, and their number was (66) families, and the researcher relied on a questionnaire consisting of (18) questions, and the study concluded that the psychological problems came average with an arithmetic mean (2.29),The study also found that the highest psychological problems are the problem of frustration with an arithmetic average (2.36) represented in "I am no longer assured of the future of my child" and the least psychological problems are the problem of anxiety with an arithmetic average (2.22) represented in "my sleep has become disturbed" followed by social problems with an arithmetic average (2.19) where the highest social problems came the problem of spending leisure time with an arithmetic average (2.34) represented in I find it difficult to accompany my child in public places, then problems outside the family with an arithmetic average (2.12) and then problems within the family with an arithmetic average(2.11)The researcher recommends early professional intervention for the social and psychological problems facing the families of children with cerebral palsy through family therapy, solution-based therapy, and evidence-based cognitive-behavioral therapy in social work.
Smallholder Tomato Production in Mwanza Region- A Technical Efficiency Analysis Approach.
Authors: Kongolo M. , Tesha J. 
Published: April 2023

This study measured technical efficiency and its determinants in maize production by small-scale producers in Mwanza region, using a stochastic frontier production function approach. A randomly selected sample of participants in the two districts was used. The Maximum Likelihood estimation procedure was followed to obtain the determinants of technical efficiency and technical efficiency levels of small-scale tomato producers. The minimum and maximum values of technical efficiency were between 20% and 91%, indicating that the least practices of specific producer operates at a minimum level of 20%, while the best practice producers operate at 91% technical efficiency level respectively. The summary results of the mean technical efficiency was 57%. The results indicate that farmers were not fully technically efficient with a mean technical efficiency score of 0.58. The study also revealed that most of the farmers irrespective of the size of the holdings have shown technical inefficiency problems. Experienced farmers were observed to have good measures of technical efficiency. The findings also indicated that significant variables of technical efficiency included household size, labour, fertilizer, seed, educational level, household size, farming experience, and access to extension services were statistically significant by positively impacted on producers’ technical efficiency in the study area.
A juventude evangélica brasileira e suas práticas culturais em Lisboa
Authors: Cardoso Kaique , Rodrigues Donizete , Lanza Fabio 
Published: April 2023

Neste artigo evidenciamos diferentes teorias a respeito das juventudes, possibilitando uma ampla compreensão acerca desta categoria que pode ser analisada a partir de diferentes perspectivas, entre elas, a das práticas culturais. A investigação, de cunho qualitativo, explora as histórias de vida de treze jovens brasileiros evangélicos e aborda as problemáticas em torno dos elementos que compõem as práticas culturais, com ênfase no lazer e dos tempos livres, tendo como resultado diversas práticas culturais, dentre elas: Streaming, Música, Leitura, Cinema, Igreja e Turismo.