bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crucial Roles of SATB1 in Regulation of Thymocyte Migration after Positive Selection
Authors: Naito Taku , Ise Marii , Tanaka Yuriko , Kohwi-Shigematsu Terumi , Kondo Motonari 
Published: May 2023

Abstract
Double-positive thymocytes that have passed positive selection migrate from the cortex to the medulla, where negative selection and the development of thymic regulatory T cells (tTregs) take place. Medullary thymic epithelial cells (mTECs) play important roles in these selections, and their differentiation and maintenance depend on interaction with positively selected CD4+ single-positive cells. Therefore, migration and differentiation after positive selection must be coordinated to establish immune tolerance. However, the regulatory mechanisms of these processes are not fully understood. SATB1 is a genome organizer highly expressed in double-positive thymocytes, and SATB1 deletion causes various defects in T-cell development, including impaired positive and negative selection and tTreg differentiation. Here, we show that SATB1 is critical for temporally coordinated thymocyte trafficking after positive selection in mice. Satb1 knockout (ΔSatb1) led to precocious thymic egress caused by augmented S1pr1 upregulation in positively selected thymocytes, accompanied by lower induction of Ccr7, Tnfsf11, and Cd40lg. Altered thymocyte trafficking and functionality affected the differentiation of mTECs and, in turn, tTreg differentiation. Thus, SATB1 is required to establish immune tolerance, at least in part, by ensuring timely thymic egress and mTEC differentiation.
Association between serum albumin levels and disease severity in adult patients with dengue
Authors: Wang Changtai , Yang Huiqin , Xu Jielan , Wang Jian , Zhao Lingzhai , Hong Wenxin , Zhang Fuchun 
Published: May 2023

Objective:
To identify the association between serum albumin levels and disease severity among adult patients with dengue in mainland China.

Methods:
This retrospective cohort study analyzed the data of adult patients (aged ≥ 18 years) hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in mainland China. Serum albumin levels were estimated and compared between patients with severe dengue and non-severe dengue. Additionally, the association between serum albumin levels and severe dengue was evaluated using a generalized linear model [relative risks (RR)]. Multivariate logistic regression analysis was performed to identify the potential predictors of severe dengue.

Results:
Overall, 1568 patients were included in this study. Of these patients, 34 (2.17%) developed severe dengue. The median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue (33 g/L vs. 37 g/L, P<0.001). After adjustment for age, sex, and comorbidities, hypoalbuminemia (RR 4.877, 95% CI 2.193-11.461, P<0.001) was found to be a predictor of severe dengue. Serum albumin levels (OR 1.303, 95% CI 1.161-1.462, P<0.001)] and age (OR 1.038, 95% CI 1.017-1.061, P<0.001) were significant risk factors for severe dengue. The area under the curve for serum albumin levels to distinguish severe dengue was 0.787.

Conclusions:
Lower serum albumin levels were significantly associated with disease severity in adult patients with dengue. Hypoalbuminemia on admission resulted in at least a four-fold increased risk of severe dengue.
Dermatological Quality of Life among Leprosy Patients Residing at a Rehabilitation Center in North-Eastern India: A Cross-Sectional Study
Authors: Samanta Sampriti , Bandyopadhyay Alapan , Bhattacherjee Sharmistha , Mukherjee Abhijit 
Published: May 2023

Background:
Leprosy has been affecting humans since ancient times. A chronic infectious disease, it affects skin, peripheral nervous system, and other tissues which lead to nerve damage, pain, and visible deformities. The characteristic skin lesions of leprosy can lead to significant social stigmatization and functional impairments which can affect the quality of life (QoL).

Objective:
The present study was conducted to assess the dermatological QoL among these leprosy patients.

Materials and Methods:
An observational cross-sectional study was conducted among 122 leprosy patients who were receiving treatments at a rehabilitation center in North-Eastern India in a 3-month time period. The dermatology QoL Index (DQLI) questionnaire was used to assess the QoL among these patients. Descriptive statistics and logistic regression analyses were used.

Results:
Among a total of 122 patients, leprosy had no effect on QoL in 4.9%, small effect in 11.5%, moderate effect in 37.7%, very large effect in 43.4%, and extremely large effect in 2.5% cases. Mean DQLI score was 10.5 ± 5.1. The most affected domain was leisure and social followed by symptoms and feelings. When adjusted for predictors, age and sex were found to have a significant association with QoL.

Conclusions:
Leprosy with dermatological manifestations had a very large effect on QoL. The impairment was more than other chronic skin diseases, such as chronic urticaria, vitiligo, and psoriasis. It is necessary that periodic assessment of QoL should be incorporated into the management of leprosy patients.
Investigating the Psychoacoustic Characteristics of Absorbents used in Common Earmuffs: A Laboratory Study
Authors: Amini Zahra , Asady Hadi , Pourabdian Siamak , Forouharmajd Farhad 
Published: May 2023

Introduction:
In addition to having auditory effects, sound also has nonauditory effects. Acoustic Annoyance is one of the nonauditory effects of sounds which are construed as psychoacoustic characteristics. The study at hand was undertaken to investigate the psychoacoustic characteristics of absorbents used in common earmuffs.

Materials and Methods:
In this study, four earmuffs prevalent in industries were used. The psychoacoustic characteristics of loudness and sharpness were measured and analyzed in sound levels of 75, 85, and 95 dB using an impedance tube and Va-Lab 4 software with and without absorbers. The results were analyzed with SPSS-26 software.

Results:
Results showed that the highest and the lowest increase in loudness were attributed to the EM-101 and the EM-104, respectively. In addition, with the increase in the sound level, the loudness increased. Furthermore, in 85 dB, there was no significant relationship between loudness and earmuff absorber only in the case of the earmuff EM-103. Furthermore, the highest and the lowest increase in sharpness were, respectively, attributed to the EM-101 and the EM-103. Only in the samples of EM-103 and EM-104 earmuffs at the level of 75 dB, there was no significant relationship between sharpness and earmuff absorber.

Conclusion:
Earmuffs used in industries showed different performances against the loudness and sharpness of the sound. In other words, the quality and the structure of earmuff absorber play noteworthy roles in decreasing the qualitative parameters of sound.
Tirzepatide as a novel therapeutic option for patients with type 2 diabetes: A pooled analysis of subgroups of SURPASS 1-5 trials
Authors: Abdalla Mohammed Altigani , Soyiri Ireneous , Atkin Stephen , Sathyapalan Thozhukat 
Published: May 2023

Abstract

Aim:
The aim of this study was to evaluate the impact of patients’ characteristics on the efficacy and the safety of subcutaneous tirzepatide once-weekly in patients with uncontrolled type 2 diabetes mellitus (T2DM).

Materials and Methods:
This post hoc analysis of pooled SURPASS 1-5 randomized controlled trials narratively examined changes from baseline in hemoglobin A1c (HbA1c) and body weight and the proportions of patients who achieved the endpoint composite HbA1c with tirzepatide (5, 10, and 15 mg) across the following subgroups; baseline HbA1c (≥ 7.5% to ≤8.0% [≥48 ≤ 64 mmol/mol], ≥8.0% to ≤8.5% [≥64 ≤68 mmol/mol], and ≥ 8.5% to ≤9.0% [≥68 ≤75 mmol/mol]), baseline diabetes durations (≤ 5 years, 5–10 years, and ≥ 10 years), and age (non-elderly ≤ 60 years and elderly ≥ 60 years).

Results:
Based on diabetes duration, the mean HbA1c reduced from baseline (≥–1.87 % to ≤–2.24% [≥–20.57 to ≤–24.64 mmol/mol]) for tirzepatide 5 mg (P = 0.308), –1.89 % to –2.43% (–20.79 to –26.73 mmol/mol) with tirzepatide 10 mg (P = 0.015) and ≥–2.07 % to≤ –2.58 % (≥–22.77 to ≤–28.38 mmol/mol) with tirzepatide 15 mg (P = 0.010). Similar HbA1c and body weight reductions were observed across other subgroups (baseline HbA1c and age).

Conclusion:
Tirzepatide was consistently efficacious and safe in the broad spectrum of patients with T2DM subgroups across the SURPASS 1-5 trials.
Health literacy, medication belief, and demographic factors as correlates of medication adherence in person with diabetes mellitus
Authors: Olorunfemi Olaolorunpo 
Published: May 2023

Abstract

Background:
A rise in the number of people with diabetes is possible if immediate action is not taken to reverse the trend. Diabetes mellitus is a chronic medical condition that has serious health consequences for people. The goal of this study was to investigate the relationships between medication adherence, health literacy, and demographic characteristics.

Materials and Methods:
This correlational study methodology was used at the University of Benin Teaching Hospital in Benin City in 2020. The study included 180 diabetes participants. The tools used included belief about medications questionnaires (BMQ), medication adherence rating scales (MARS), and the Short Functional Health Literacy in Adults Test (STOHFLA), and used linear regression, descriptive statistics, and Spearman’s rho correlation.

Results:
The researcher discovered that 66.7% of the people lacked adequate health literacy, and MARS analysis revealed that medication adherence was low. Age and income level both had relationships with medication adherence, but marital status, and education did not. The researcher also found a link between medication adherence, health literacy, and medication belief using P-values of 0.004 and 0.002. The regression model indicates that age, medication belief, health literacy, and economic and income level are predicting factors for medication adherence.

Conclusion:
Nurses and hospital administrators need to focus more on the health literacy, age, income level, and health beliefs of their patients because there is evidence that these aspects are statistically associated with medication adherence.
Uso del podcast corporativo como herramienta de comunicación de los ODS en el sector bancario español
Authors: Barrio-Fraile Estrella , Barbeito-Veloso María Luz , Fajula-Payet Anna , Perona-Páez Juan José , Enrique-Jiménez Ana María 
Published: May 2023

Introducción: La RSC se erige como el mecanismo a través del cual las organizaciones integran los ODS en sus estrategias corporativas. Por otra parte, la comunicación de las iniciativas de responsabilidad y compromiso con la ciudadanía representan un factor importante en la consecución de la legitimidad social de la empresa. Además, las herramientas de comunicación digital, entre las que se encuentra el podcast corporativo, se presentan como potentes aliadas para difundir un mensaje de marca corporativa alineada con la sostenibilidad, el compromiso y la responsabilidad social. Por todo ello, el objetivo principal de este artículo es analizar el uso que hace el sector bancario del podcast corporativo como herramienta para comunicar contenido relacionado con los ODS. Metodología: Se ha realizado un análisis de contenido de los titulares y textos explicativos de las entregas de podcast emitidas por las entidades financieras de mayor envergadura en España durante el año 2022. Resultados: El 36,1% de los podcasts analizados aborda los ODS, concretamente se ha obtenido una representación de 12 de los 17 ODS marcados por las Naciones Unidas. Discusión: Los resultados muestran un uso significativo del podcast corporativo como herramienta de comunicación de los ODS, lo cual va en línea con la creciente apuesta de las empresas por una comunicación más comprometida vinculada a la RSC. Conclusiones: Esta investigación supone un paso más en el conocimiento del uso que hacen las organizaciones de las posibilidades comunicativas que proporcionan las plataformas digitales, en concreto el podcast, para comunicar temas relacionados con la RSC.
El desempleo y la violencia contra la mujer en Guatemala
Authors: Morales Ixcajó Leonel Humberto 
Published: May 2023

PROBLEMA: Guatemala ha sido azotado por la violencia desde la colonia, las dictaduras del siglo XIX, el conflicto armado interno, hasta el llamado tiempo de paz que precede a la actualidad. La discriminación y exclusión social como una manifestación de la violencia contra la mujer tienen un impacto en el bienestar de la población, y merman la oportunidad de acceso al empleo en los mercados formales al históricamente vulnerado segmento de la mujer. OBJETIVO: analizar la participación de la mujer de Guatemala en el empleo y las consecuentes implicaciones que la violencia contra la mujer tiene en éste. MÉTODO: se utilizó el método analítico y técnicas de observación para el estudio retrospectivo de 2010 a 2021 para comprender la naturaleza particular de los fenómenos. RESULTADOS: la tasa de desempleo de la mujer no disminuye al mismo ritmo que la del hombre. La falta de inclusión y oportunidad laboral en el sector formal para la mujer, producto de la discriminación social, se refleja en su alta participación en el sector informal, cuya condición se agudiza cuando existe una combinación de elementos como: sexo, etnia, localidad. CONCLUSIÓN: la brecha de desigualdad por el acceso al empleo entre el hombre y la mujer sigue creciendo, además, los instrumentos para el combate delictivo de la violencia contra la mujer son insuficientes y no han mitigado los efectos de exclusión.
THE MEDIATING EFFECT OF TEAMWORK ON THE RELATIONSHIP BETWEEN WORK ATTITUDE AND JOB SATISFACTION OF TEACHERS
Authors: Quines Lyndon A. , Nino Archie V. 
Published: May 2023

The purpose of this study was to determine the mediating effect of teamwork on the relationship between work attitude and job satisfaction of teachers. Utilizing quantitative, non-experimental design via correlational technique, data were obtained from 300 elementary public school teachers who belong to the 3 districts, Magsaysay, Bansalan and Matan-ao under the Division of Davao Del Sur. Davao Del Sur. The researcher utilized a stratified random sampling technique and an online survey mode of data collection. The researcher also utilized the statistical tools mean, Pearson r and Medgraph using Sobel z-test. From the results of the study, it was found out that the overall mean scores of teamwork, work attitude and job satisfaction of teachers are very high. Also, results revealed that there are significant relationships between work attitude and job satisfaction, between work attitude and teamwork and between teamwork and job satisfaction of teachers. Further, it was revealed that there was a partial mediation effect of teamwork on the relationship between work attitude and job satisfaction of teachers.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0087/a.php" alt="Hit counter" /></p>
PRE-COVID-19 PHYSICAL ACTIVITY STATUS DOES NOT PROTECT AGAINST REDUCTIONS IN POST-COVID-19 SYMPTOMS: A CORRELATION RELATIVISTIC ANALYSIS DURING THE LOCKDOWN
Authors: Owen Rebecca , Faghy Mark A. , Ashton Ruth E. M. , Ferraro Francesco V. 
Published: May 2023

People who exhibit unhealthy lifestyle behaviours are at greater risk of severe disease outcomes, risk of hospitalisation and mortality when infected with COVID-19. Accordingly, it is suggested that those with higher levels of cardiorespiratory fitness and who engage in regular physical activity (PA) are associated with a reduced risk of adverse outcomes. Although improved physiological function may protect individuals against severe acute COVID-19 outcomes, it is unknown whether it offers protection against developing sustained symptom profile, known as post-acute COVID-19 syndrome or Long COVID. Affecting an estimated 2 million people in the UK and 144 million globally, Long COVID is challenging healthcare services with broader social and economic impacts. Accordingly, this project aimed to determine the impact of PA status on Long COVID. An online survey was developed Utilizing adapted versions of preexisting Patient Re-ports Outcome Measures (Qualtrics, Provo, Utah, United States). Participants self-reported PA status in line with the World Health Organisation guidelines and their pre- and post-COVID-19 health status and symptom profile. A Mann-Whitney U test was used to analyse between-group responses, and a Wilcoxon Signed Rank test was used to analyse within-group responses. The survey was completed by 381 participants, of which n=253 reported meeting or exceeding the recommended guidelines of PA. A significant difference was found between pre- and post-COVID-19 health, whilst a Mann-Whitney U test concluded that there was no significant difference between PA groups and post-COVID-19 health status. According to the results, increased PA and cardiorespiratory fitness might offer protection against severe disease outcomes in the acute phase of infection but this does not offer full protection against developing a long-term symptom profile and increased mechanistic understanding of the physiological determinants is needed to restore the pre-COVID-19 status and assist in the development of multi-disciplinary interventions.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0025/a.php" alt="Hit counter" /></p>
Why war won and negotiations lost? Is the absence of war the same as peace?
Authors: Libaridian Gerard 
Published: May 2023

The article comparatively analyzes the systemic dependence of military victory and negotiation defeat, which is manifested in a situation of absence of war and still unsettled peace. The article examines the negotiations on the settlement of the Karabakh conflict, along with cooperation and struggle, which constitute the main form of expression of world and regional politics in the modern world.
Taking into account the genesis and changing nature of the Karabakh conflict, the author analyzes the main reasons why the negotiations on the settlement of the Karabakh conflict were not successful. In this context, the purpose of this article is to study the process of conducting international negotiations of the Karabakh conflict, its structural and functional components, to analyze the negotiation activity as a means of settling and resolving conflict situations in Nagorno-Karabakh, the implementation of international cooperation, as well as to study the main characteristics of the negotiation process between Armenia and Azerbaijan.
The author focuses on the military, political and diplomatic dimensions of the Nagorno-Karabakh conflict from 1988 to its last phase in 2020. The negotiation process to resolve the conflict in this article is considered, both in terms of their content, results and positions of their participants, as well as in terms of the procedural side of the negotiation.
Strategi Komunikasi Islam Komunitas Muslim Upgrade Dalam Memotivasi Pentingnya Pendidikan di Kalangan Remaja Desa Denai Sarang Burung Kecamatan Pantai Labu
Authors: Nadila Nurhaida , Ritonga Elfi Yanti 
Published: May 2023

This research is about the Islamic communication strategy played by the Upgrade Muslim Community which aims to motivate the importance of education among adolescents in Denai Nest Bird Village, Pantai Labu District. This study uses field observation research and interviews with qualitative methods. The fundamental reason for raising this phenomenon by researchers is because the Upgrade Muslim Community is able to influence the people in the village by using the Qur'an and hadith as a guide to convey messages that can motivate the community. Qaulan sadidan and qaulan balighan are the principles of Islamic communication used. To create a quality, educated generation is the right effort for this, therefore it is very important for teenagers to prioritize education. The upgraded Muslim community conducts outreach, seminars and makes banners to convey things that can change people's mindsets. Apart from that, social media is also used as a means of disseminating information and means of communication in realizing the strategies that have been designed. There are several obstacles that occur in carrying out these activities, but these obstacles can be resolved appropriately by the community itself. The Islamic communication strategy used is an effective strategy to achieve the stated goals.
Keyword : Strategy, Islamic Communication, Education
Role of Individualized Homoeopathic Medicine in Urticaria: A Case Report
Authors: Gupta Yogeshwari , Rastogi Stuti 
Published: May 2023

Urticaria is a vascular reaction of the superficial portion of the dermis. It is characterized by appearance of erythematous, oedematous papules or plaques known as wheals. The present article is a case report of a 17-year-old male visited to the OPD of Swasthya Kalyan Homoeopathic Medical College and Research Centre with the complaint of eruptions (wheals) on left forearm. After complete case taking and thorough analysis and repertorization using synthesis repertory, Phosphorus 30C was selected and prescribed based on individualization. This article illustrates the beneficial effects of Homoeopathic medicine Phosphorus in the case of Urticaria.
Upadacitinib (Rinvoq)
Authors: CADTH  
Published: May 2023

CADTH recommends that Rinvoq be reimbursed for the treatment of adults with active ankylosing spondylitis (AS) who have had an inadequate response to a biologic disease-modifying antirheumatic drug (bDMARD) or when use of those therapies is inadvisable only if certain conditions are met.
Eligibility for Rinvoq should be based on the criteria used by each of the public drug plans for reimbursement of bDMARDs for the treatment of adult with active AS who have had an inadequate response to a bDMARD, are intolerant, or who have contraindications to bDMARDs.
Rinvoq should only be reimbursed if it is prescribed by a rheumatologist. For patients with other manifestations, an ophthalmologist, gastroenterologist, or dermatologist may be consulted. Rinvoq should not be reimbursed when used in combination with bDMARDs or other Janus kinase (JAK) inhibitor treatments for active AS. The cost of Rinvoq should not exceed the drug program cost of treatment with the least expensive bDMARD reimbursed for the treatment of AS.