bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of investment and international trade on the Gross Domestic Product of the fisheries sector in Indonesia: evidence from the Panel Vector Autoregressive (P-VAR) Model
Authors: Sulistijowati R , Yuliati Lilis , Komariyah Siti 
Published: July 2023

Abstract
The aim of this study is to identify the dynamics of Gross Domestic Product growth in the Indonesian fisheries and marine sector. This is important to study considering that Indonesia is a country that has abundant marine wealth but faces several challenges such as production quality, investment growth, global uncertainty, and the international trade cycle. Thus, this study considers several variables, namely the GDP of the fisheries and marine sector, domestic investment, foreign direct investment, imports and exports of the fishery sector, and the volume of production in the fisheries sector. The research method used is a panel vector autoregression (P-VAR) model involving impulse response functions and variance decomposition tests. The results of the P-VAR estimation suggest that the variables that have a significant impact on the GDP of the Indonesian fishery sector are the GDP of the fishery sector itself, domestic investment, foreign direct investment, exports of the fishery sector, and the volume of production in the fishery sector. The results of the study indicate the need for implementing policies that are in accordance with the dynamics of the marine economy through coordination of all upstream and downstream sectors; developing and advancing the industrialization of fishery products; fulfilling international product standards; increasing the quantity and quality of environmentally friendly production; improving fishermen’s welfare; and implementing related policies in international trade.
Effect of Mesh Size and Hanging Ratio Gillnet to the Local Marketable Size of Giant Trevally Caranx ignobilis
Authors: Haruna  , Tupamahu A , Silooy F D , Hehanussa K G 
Published: July 2023

Abstract
Gillnets are widely used by small-scale fishermen to catch giant travelly Caranx ignobilis in coastal waters, the dominant fish caught are small in size not according to market size. The parameters of gillnet such as mesh size and hanging ratio can optimize the target size. The purpose of this study was to analyze the effect of mesh size and hanging ratio of gillnets on the size of the local marketable size for C ignobilis. The fishing experiment was carried out in floating net cages at the Ambon Fisheries Training and Extension Center (BPPP) from June to August 2022. A Simple randomized experimental designed with a factorial pattern was used as the experimental model. The different mesh size were used as treatments, and they are 2.5, 3.0 and 3.5 inches (3 factors) and the hanging ratio consisted of 70%, 50% and 30% (3 factors). The population of C ignobilis that was used in this study with the middle of the class ranged from 24.5 to 29.5 cm total length. There is an effect of mesh size factor on the size of the target market for C ignobilis, where the mesh size of 3.0 inches is more effective than the others. In addition, the hanging ratio value affects the catch size of the local target market, where the hanging ratio value of 30% is more effective than the hanging ratio value of 70%. .
Assessment of habitat and reef fish population characteristics in Pari Island cluster waters Seribu Archipelago Indonesia
Authors: Syam A R , Hartati S T , Mujiyanto  , Sugianti Y , Nastiti A S , Sulardiono B 
Published: July 2023

Abstract
The Pari Island Cluster, located on the Southside of the Seribu Archipelago, is bordered by Jakarta and Tangerang Regency is covered Pari, Kudus, and Tikus Islands. The Pari Island cluster has potential ecosystems, such as coral reefs, seagrass, and mangrove. The presentation of this article is an overview of the results of research conducted by the Research Institute for Marine Fisheries and the Research Institute for Fisheries Enhancement, The Agency for Marine and Fisheries Research and Human Resources. This study aims to present and describe habitat and reef fish populations. The assessment result shows that the criteria for the coral reefs’ health were poor to good, mostly moderate, the best in the southeast and northeast waters, which had been designated MPAs. Reef fish population density on the criteria was very rare or low at all observation sites. The dominant group was Caesio cuning, Cephalopholis boenak, Scarus ghobban (target group), and Chaetodon octofasciatus (indicator group). The implementation hopes Pari Island Cluster waters would expand to be designated MPAs due to the large number of care areas used for fishing territories.
Characteristics of clamshell flour Donax sp from Sapola sub-village of Seram Island
Authors: Lalopua V , Sukisman A H 
Published: July 2023

AbstractClam meat is consumed by the people of Sapola sub-village on Seram Island, and the shells are processed into flour by roasting and soaking in a husk ash solution. This traditional method, with its simple and inexpensive equipment, causes pollution. Another method of producing shell flour that uses NaOH as a solvent has resulted in shell flour with high mineral content. The objective of this study was to compare the physical and chemical properties ofDonaxsp shell flour using the traditional method and the chemical method with NaOH solution. Laboratory analysis was used as the research method in this study. The process included examinations on shape, size, color, and yield of the shell flour, as well as the water content and mineral content of CaCO3, MgO, SiO2, and sulphur. The results revealed differences in the physical properties and mineral content of clam shell flour when using traditional and chemical methods.Donaxsp shell flour obtained by soaking purplish-white NaOH, powder form size 18 mesh size, CaCO3 content of 96.60%, MgO 0.03%, SiO2 0.33%, Sulphur 0.02%, water 0.27%, yield 41.67%, while clam shell flour obtained by burning silver white, powder form size 18, CaCO3 content of 85.92%, MgO 0.06%, SiO2 0.33%, Sulphur 0.01%
How I diagnose myeloid neoplasms with germline predisposition
Authors: Patel Nisha , Calvo Katherine R 
Published: July 2023

Abstract

Objectives
Pathologists play a crucial role in the initial diagnosis of germline predisposition to myeloid neoplasia and subsequent surveillance for disease progression. The diagnostic workup can be challenging, particularly if clinical history, laboratory testing, or genetic studies are incomplete or unavailable.

Methods
Through case-based examples, we illustrate common diagnostic challenges and pitfalls encountered during bone marrow examination of patients being evaluated for myeloid malignancy with potential germline predisposition to myeloid neoplasia.

Results
Lack of familial disease, the absence of syndromic manifestations, and late-onset hematologic malignancy do not exclude an underlying germline predisposition syndrome. Targeted myeloid sequencing panels can help identify potential germline alterations but may not detect large deletions or insertions, noncoding, or novel variants. Confirmation of the germline nature of an alteration detected in the peripheral blood or bone marrow ideally requires genetic testing using nonhematopoietic germline DNA to definitively distinguish between germline and somatic alterations. The ideal tissue source for germline testing is cultured skin fibroblasts. Certain germline predisposition syndromes can contain characteristic baseline bone marrow dysplastic-appearing features associated with cytopenias without constituting myelodysplastic syndrome.

Conclusion
Recognizing germline predisposition to myeloid neoplasia is critical for proper disease management. This recognition is particularly important for patients who will undergo hematopoietic stem cell transplantation to screen potential related donors. Integration of the clinical history, bone marrow findings, cytogenetic studies, and specialized laboratory and molecular genetic testing is often essential for accurate diagnosis and subsequent disease monitoring.
BRAF testing modalities in histiocytic disorders: Comparative analysis and proposed testing algorithm
Authors: Acosta-Medina Aldo A , Abeykoon Jithma P , Go Ronald S , Goyal Gaurav , Ravindran Aishwarya , Schram Susan M , Rech Karen L 
Published: July 2023

Abstract

Objectives
Understanding of histiocytic disorders has been revolutionized by demonstration of mitogen-activated protein kinase (MAPK) pathway mutations, most commonly BRAFV600E. The optimal testing strategy to assess BRAFV600E is unknown. We aimed to compare performance of testing modalities, to propose a framework for evaluation of BRAFV600E mutation status in histiocytic disorders.

Methods
We retrospectively reviewed patients with histiocytic disorders and BRAF mutation testing on a lesional tissue specimen.

Results
In 120 patients, BRAF assessment included immunohistochemistry (IHC) in 97 (80.2%), polymerase chain reaction (PCR) in 35 (28.9%), and next-generation sequencing (NGS) in 62 (51.2%). Forty-five underwent both NGS and IHC. With NGS as the gold standard, the sensitivity and specificity of IHC were 82.4% and 96.4%. Three false negatives were observed in biopsy specimens with low BRAFV600E variant allele frequency or decalcified tissue. One false-positive IHC was observed in a lung biopsy specimen, likely due to antibody cross-reactivity with respiratory cilia. Among 14 with successful NGS and PCR, a single discordance was observed. Two PCR-to-IHC discrepancies were observed, including one other false-positive IHC.

Conclusions
Immunohistochemistry was highly specific for detection of BRAFV600E. Main caveats were false negatives and lack of detection of non-BRAFV600E mutations. We propose the use of IHC as initial screening in general practice with reflex molecular testing if negative.
Standing Blood Pressure and Risk of Falls, Syncope, Coronary Heart Disease, and Mortality
Authors: Kondo Jordan K , Earle William B , Turkson-Ocran Ruth-Alma N , Ngo Long H , Cluett Jennifer L , Lipsitz Lewis A , Daya Natalie R , Selvin Elizabeth , Lutsey Pamela L , Coresh Josef , Windham Beverly Gwen , Kendrick Karla N , Juraschek Stephen P 
Published: July 2023

Abstract

BACKGROUND
ACC/AHA guidelines caution against the use of antihypertensive therapy in the setting of low standing systolic BP (SBP) &lt; 110 mm Hg due to unclear benefits.

METHODS
The Atherosclerosis Risk in Communities (ARIC) Study measured supine and standing SBP in adults aged 45–64 years between 1987 and 1989. We used Cox regression to evaluate the associations of low standing SBP (&lt;110 mm Hg) with risk of falls, syncope, coronary heart disease (CHD), and mortality through December 31, 2019. Falls and syncope were ascertained by hospitalization and outpatient claims; CHD events were adjudicated. Associations were examined overall and in strata of hypertension stage, 10-year atherosclerotic cardiovascular disease (ASCVD) risk, age, and sex.

RESULTS
Among 12,467 adults followed a median of 24 years (mean age at enrollment 54.1 ± 5.8 years, 55% women, 26% Black adults), 3,000 (24%) had a standing SBP &lt; 110 mm Hg. A standing SBP &lt; 110 mm Hg compared to standing SBP ≥ 110 mm Hg was not significantly associated with falls or syncope, and was associated with a lower risk of CHD events and mortality with HRs of 1.02 (95% CI 0.94, 1.11), 1.02 (0.93, 1.11), 0.88 (0.80, 0.97), and 0.91 (0.86, 0.97), respectively. There were no clinically meaningful differences when stratified by hypertension stage, 10-year ASCVD risk, age, and sex.

CONCLUSIONS
In this community-based population, low standing SBP was common and not significantly associated with falls or syncope, but was associated with a lower risk of CHD and mortality. These findings do not support screening for low standing BP as a risk factor for adverse events.
Identification of bolegrevilol B and C as novel antioxidant compounds in Suillus grevillei mushroom
Authors: Shimagami Maho , Sugaya Maho , Kimura Hinako , Shindo Kazutoshi 
Published: July 2023

ABSTRACT
Suillus grevillei is a popular species of mushroom available worldwide. In this study, we isolated compounds, bolegrevilol B and bolegrevilol C, from the mushroom and observed their potent lipid peroxidation-inhibiting activity. The structures of bolegrevilol B and bolegrevilol C were elucidated as 3-geranylgeranyl-1,2,4-trihydroxybenzene and 3-geranylgeranyl-1,2-dihydroxy-4-methoxybenzene, respectively, through high-resolution electrospray ionization mass spectrometry (-) and 1D and 2D nuclear magnetic resonance analyses. Bolegrevilol B and C inhibited lipid peroxidation and exhibited IC50 values of 2.0 ± 0.29 µm and 1.0 ± 0.13 µm, respectively. Furthermore, bolegrevilol B and C demonstrated potent neuroprotective activities in neuronal hybridoma N18-RE-105 cells against L-glutamate toxicity (EC50 of 1.8 ± 1.7 n m and 7.2 ± 6.9 n m, respectively). Bolegrevilol B was found in nature for the first time, and, to the best of our knowledge, this is the first study to report the antioxidant activities of bolegrevilol B and C.
Deep transfer learning for clinical decision-making based on high-throughput data: comprehensive survey with benchmark results
Authors: Toseef Muhammad , Olayemi Petinrin Olutomilayo , Wang Fuzhou , Rahaman Saifur , Liu Zhe , Li Xiangtao , Wong Ka-Chun 
Published: July 2023

Abstract
The rapid growth of omics-based data has revolutionized biomedical research and precision medicine, allowing machine learning models to be developed for cutting-edge performance. However, despite the wealth of high-throughput data available, the performance of these models is hindered by the lack of sufficient training data, particularly in clinical research (in vivo experiments). As a result, translating this knowledge into clinical practice, such as predicting drug responses, remains a challenging task. Transfer learning is a promising tool that bridges the gap between data domains by transferring knowledge from the source to the target domain. Researchers have proposed transfer learning to predict clinical outcomes by leveraging pre-clinical data (mouse, zebrafish), highlighting its vast potential. In this work, we present a comprehensive literature review of deep transfer learning methods for health informatics and clinical decision-making, focusing on high-throughput molecular data. Previous reviews mostly covered image-based transfer learning works, while we present a more detailed analysis of transfer learning papers. Furthermore, we evaluated original studies based on different evaluation settings across cross-validations, data splits and model architectures. The result shows that those transfer learning methods have great potential; high-throughput sequencing data and state-of-the-art deep learning models lead to significant insights and conclusions. Additionally, we explored various datasets in transfer learning papers with statistics and visualization.
Factors associated with recurrent appendicitis after successful treatment with antibiotics
Authors: Flum David R ,   writing group for the CODA Collaborative, Rosen J E , Voldal E C , Davidson G H , Monsell S E , Fannon E E C , Lawrence S O , Krishnadasan A , Talan D A , Bizzell B , Heagerty P J , Comstock B A , Lavallee D C , Kessler L G , Thompson C M , Self W H , Evans H , Kao L S , Dodwad S , Sabbatini A K , Hemmila M , Sangji N , Gibbons M M , Saltzman D , Kaji A H , DeUgarte D A , Mandell K A , Siparsky N , Price T P , Villegas C , Winchell R , Wisler J , Victory J , Jones A , Kutcher M , Hatch Q , Holihan J , Liang M K , Cuschieri J , Patton J H , Fischkoff K , Drake F T , Sanchez S E , Flum D R 
Published: July 2023

Abstract

Background
As more patients with appendicitis are treated with antibiotics, factors associated with recurrence may help inform individualized prognostication and decision-making.

Methods
This cohort study, using data from the Comparison of Outcomes of Antibiotic Drugs and Appendectomy trial, examined patients treated with antibiotics who did not undergo appendicectomy in the first 30 days. Patients who had appendicectomy between 30 days and 1 year were compared with those who did not. Marginalized logistic regression models were used to calculate adjusted risk differences (RDs) to estimate the association between baseline patient factors and the risk of undergoing an appendicectomy between 30 days and 1 year.

Results
Of 601 patients treated with antibiotics who did not undergo appendicectomy within 30 days (mean age 38.0 years; 217 women (36.1 per cent)), 144 had an appendicectomy and 56 were lost to follow-up between 30 days and 1 year. The estimated rate of appendicectomy between 30 days and 1 year was 28.6 (95 per cent c.i. 25.0 to 32.8) per cent. After adjustment for other factors, nausea, vomiting, or anorexia at baseline presentation was associated with an increased rate of appendicectomy between 30 days and 1 year (adjusted RD 17.52, 95 per cent c.i. 8.64 to 26.40). The presence of an appendicolith (adjusted RD 3.64, −6.08 to 13.36), or an abscess, perforation, or fat stranding on initial imaging (adjusted RD −7.23, −17.41 to 2.95) was not strongly associated with appendicectomy between 30 days and 1 year.

Conclusion
Most factors commonly associated with appendicitis severity were not strongly associated with an increased risk of undergoing appendicectomy in the longer term after treatment with antibiotics.
Surrounded by concrete: genetic isolation of Tillandsia recurvata L. in an urban landscape in southeastern Brazil
Authors: Quail Megan Rhianne , Ramos Flavio Nunes , Dallimore Thom , Ashton Paul , Clayton-Brown Jennifer , Provan Jim , Batke Sven Peter 
Published: July 2023

Abstract
Increasing urban expansion has resulted in the decline of many natural and seminatural communities globally. However, the connectivity and genetic structure of species that survive in these urban landscapes have received little attention, especially with regard to epiphytic plants. This study aimed to describe and evaluate the connectivity and genetic structure of populations of Tillandsia recurvata, a highly abundant and widely distributed atmospheric epiphyte, amongst urban green spaces within a city. A total of 288 T. recurvata individuals were sampled across 65 trees throughout the city of Alfenas in South-East Brazil. We designed seven novel microsatellite markers and used four cross-amplified loci to determine the basic genetic structure of T. recurvata. All populations showed high global spatial genetic structure, which indicated low connectivity between urban populations. The findings of this study, as well as evidence from previous assessments of T. recurvata genetic structure, suggest that the combined effects of genetic drift, breeding system, and dispersal may have dictated the connectivity of these urban populations. This study represents an important step towards understanding epiphyte population structure within urban landscapes. Low connectivity across urban landscapes is likely to benefit epiphytes such as T. recurvata, due to their adaptability and high tolerance; this suggests a bleak future for many other more sensitive epiphytic species under predicted urbanization globally.
3D synaptic organization of layer III of the human anterior cingulate and temporopolar cortex
Authors: Cano-Astorga Nicolás , Plaza-Alonso Sergio , DeFelipe Javier , Alonso-Nanclares Lidia 
Published: July 2023

Abstract
The human anterior cingulate and temporopolar cortices have been proposed as highly connected nodes involved in high-order cognitive functions, but their synaptic organization is still basically unknown due to the difficulties involved in studying the human brain. Using Focused Ion Beam/Scanning Electron Microscopy (FIB/SEM) to study the synaptic organization of the human brain obtained with a short post-mortem delay allows excellent results to be obtained. We have used this technology to analyze layer III of the anterior cingulate cortex (Brodmann area 24) and the temporopolar cortex, including the temporal pole (Brodmann area 38 ventral and dorsal) and anterior middle temporal gyrus (Brodmann area 21). Our results, based on 6695 synaptic junctions fully reconstructed in 3D, revealed that Brodmann areas 24, 21 and ventral area 38 showed similar synaptic density and synaptic size, whereas dorsal area 38 displayed the highest synaptic density and the smallest synaptic size. However, the proportion of the different types of synapses (excitatory and inhibitory), the postsynaptic targets, and the shapes of excitatory and inhibitory synapses were similar, regardless of the region examined. These observations indicate that certain aspects of the synaptic organization are rather homogeneous, whereas others show specific variations across cortical regions.
Connectome-based fingerprint of motor impairment is stable along the course of Parkinson’s disease
Authors: Rabini Giuseppe , Pierotti Enrica , Meli Claudia , Dodich Alessandra , Papagno Costanza , Turella Luca 
Published: July 2023

Abstract
Functional alterations in brain connectivity have previously been described in Parkinson’s disease, but it is not clear whether individual differences in connectivity profiles might be also linked to severity of motor-symptom manifestation. Here we investigated the relevance of individual functional connectivity patterns measured with resting-state fMRI with respect to motor-symptom severity in Parkinson’s disease, through a whole-brain, data-driven approach (connectome-based predictive modeling). Neuroimaging and clinical data of Parkinson’s disease patients from the Parkinson’s Progression Markers Initiative were derived at baseline (session 1, n = 81) and at follow-up (session 2, n = 53). Connectome-based predictive modeling protocol was implemented to predict levels of motor impairment from individual connectivity profiles. The resulting predictive model comprised a network mainly involving functional connections between regions located in the cerebellum, and in the motor and frontoparietal networks. The predictive power of the model was stable along disease progression, as the connectivity within the same network could predict levels of motor impairment, even at a later stage of the disease. Finally, connectivity profiles within this network could be identified at the individual level, suggesting the presence of individual fingerprints within resting-state fMRI connectivity associated with motor manifestations in Parkinson’s disease.
Sticky and Stuck: The Lift as a Vehicle in the Production of Social Space in Livi Michael’sUnder a Thin Moonand Loretta Ramkissoon’s “Which Floor?”
Authors: Hampton Sophie 
Published: July 2023

AbstractThis essay analyzes Livi Michael’s novel Under a Thin Moon (1992) and Loretta Ramkissoon’s short memoir “Which Floor?” (2019) to examine representations of female experience of living in high-rise social housing. My analysis draws on the work of Henri Lefebvre and Doreen Massey to investigate the production of the tower block as a social space. The lift is employed as a lens to study the structuring and shaping of the high-rise narrative and explore how fiction can both reinforce and challenge dominant mythologies of social housing. The lift’s role is considered through themes of gendered experiences of disgust (stickiness) and mobilities (getting stuck). In Under a Thin Moon, the tower block lift embodies the narrative of the failure of the utopian solutions to the postwar housing crisis in the UK and its consequences. In “Which Floor?,” although the lift is a space inherent in the facilitation and nurturing of community, it nevertheless similarly captures a narrative of the immobility of high-rise life.