bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depolymerization of polyesters by a binuclear catalyst
Authors: Niu Zhiqiang , Zhang Shengbo , Hu Qikun , Zhang Yu-Xiao , Guo Haoyue , Wu Yanfen , Sun Mingze , Zhu Xingsong , Zhang Jiangang , Gong Shuyan , Liu Ping 
Published: December 2022

Abstract
Remediation and reuse of discarded plastics can reduce their accumulation in the environment and bring energy savings for plastic production. Here we discover a binuclear zinc catalyst that features a biomimetic intramolecular pathway for polyester depolymerization, which not merely enables environmental degradation of PET but also affords industrial-scale PET recycling under relatively mild conditions. The binuclear catalyst delivers a specific activity of 36 mgPET d-1 gcatal-1 toward PET depolymerization at pH 8 and 40 oC, the very condition holding the possibility of naturally breaking down plastic waste. The structural stability of this synthetic catalyst allows it to work under wide operational conditions, resulting in a specific activity of 577 gPET h-1 gcatal-1 at pH 13 and 90 oC for centralized PET recycling. A closed-loop production of bottle-grade PET was also demonstrated. Besides, this catalyst is catalytically active toward a wide scope of substrates with high tolerance to additives and impurities.
A Novel High-Resolution Melting Method for Detection of Adulteration on Pistachio (Pistacia vera L.)
Authors: Ay Neslihan , Hürkan Kaan 
Published: December 2022

Abstract
The pistachio nut (Pistacia vera L.) is a popular nut which is beneficial for health. As a result of its high price, adulteration of pistachio products with other foods is common. The green pea (Pisum sativum L.) is similar to pistachio in colour and texture when both are in a fine powder form, therefore powdered pistachio products are often adulterated with powdered green pea. In this study, we aimed to develop a novel method based on high resolution melting (HRM) to detect green pea adulteration in powdered pistachio products as low as in ratio. Novel primers that targeted the chloroplastidial sequence atpA, rpoC1 and ycf3 were tested on admixture ratios of 90:10, 99:1, 499:1 and 999:1 of pistachio:green pea. The melting temperatures (Tm) were found to detect the adulteration for the targets rpoC1 and ycf3. Since the atpA amplicons have identical guanine-cytosine content in both pistachio and green pea PCR products, it failed to distinguish the admixtures from the positive control samples. Differential plots and genotyping confidence percentages clearly distinguished the admixtures from positive controls down to a 0.1% ratio of pistachio:green pea. Sequencing of the amplicons supported the use of HRM to distinguish between pistachio and green pea. The use of HRM with novel rpoC1 and ycf3 primer sets was found to be useful for rapid, cost-effective, and reliable detection of green pea adulteration of pistachio down to a ratio of 0.1%.
The hydroxyapatite modified 3D printed poly L-lactic acid porous screw in reconstruction of anterior cruciate ligament of rabbit knee joint: a histological and biomechanical study
Authors: Tian Ke , Wang Yafei , Bi Fanggang , Wang Zhiyuan , Ren Chengzhen , Li Pengju 
Published: December 2022

Abstract
Background
3D printing technology has become a research hotspot in the field of scientific research because of its personalized customization, maneuverability and the ability to achieve multiple material fabrication. The focus of this study is to use 3D printing technology to to customize personalized orthopedic endosseous implant porous screws and to explore its effect on tendon-bone healing after anterior cruciate ligament (ACL)reconstruction.
Methods
The poly L-lactic acid (PLLA) porous screws which meet the requirements of the experiment are prepared by 3D printing technology. The hydroxyapatite (HA) was adsorbed on porous screws by electrostatic layer-by-layer self-assembly (ELSA) technology, and PLLA-HA porous screws were prepared.Scanning electron microscope (SEM) was used to observe the surface morphology of scaffolds before and after modification. Determination of porosity of screw support by liquid replacement method. The PLLA group was fixed with PLLA porous screw and the PLLA-HA group was fixed with PLLA-HA porous screw. Histology, imaging and biomechanics were observed at 6 and 12 weeks after operation.
Results
The PLLA porous screws prepared by 3D printer meet the design requirements, and the voids in the stents are evenly distributed and connected with each other. After surface modification, HA was uniformly distributed in PLLA screw scaffolds. Histology showed that compared with PLLA group, mature bone trabeculae were integrated with grafted tendons in PLLA-HA group. Micro-CT showed that the bone formation index of PLLA-HA group was better than that of PLLA group. The new bone was uniformly distributed in the bone tunnel along the screw channel. Biomechanical experiments showed that the failure load and stiffness of PLLA-HA group were significantly higher than those of PLLA group.
Conclusions
HA modified 3D printed porous screw can not only fix the transplanted tendon, but also effectively increase the new bone mass in the bone tunnel and promote the bone integration at the tendon-bone interface by promoting the bone growth in the bone tunnel.3D printed PLLA-HA porous screws are likely to be used in clinic in the future.3D printed PLLA-HA porous screws are likely to be used in clinic in the future.
Laparoscopic common bile duct exploration with primary closure could be safely performed among elderly patients with choledocholithiasis
Authors: Fan Lili , Wang Yan , Wu Meilong , Wu Tianchong , Deng Lingna , Wang Yawei , Liu Linsen , An Tailai 
Published: December 2022

Abstract
Background
For patients with choledocholithiasis, laparoscopic common bile duct exploration (LCBDE) is preferred over open surgery. Whether primary closure of common bile duct (CBD) should be performed on completion of choledochotomy and corresponding indications for primary closure of common bile duct are still controversial topics. This study was accomplished to evaluate safety and feasibility of primary closure of CBD among elderly patients (≥ 70 years) after LCBDE.
Methods
Patients with choledocholithiasis who had undergone LCBDE with primary closure of CBD between July 2014 and December 2020 were retrospectively reviewed. Included patients were assigned into two groups (group A: ≥70 years and group B: <70 years) according to age. Group A was compared with Group B in terms of preoperative characteristics, intraoperative results and postoperative outcomes.
Results
The mean operative time for group A was 176.59 minutes (± 68.950) while the operative time for group B was 167.64 minutes (± 69.635 ) (P = 0.324). The mean hospital stay after surgery for group A was 8.43 days (± 4.440) while that for group B was 8.30 days (± 5.203) (P = 0.849). 3 patients in group A experienced bile leakage while bile leakage occurred to 10 patients in group B (3.8% VS 4.5%, P = 0.781). Group A was not significantly different from group B in terms of postoperative complications and 30-day mortality except pneumonia (P = 0.016), acute cardiovascular event (P = 0.005) and ICU observation (P = 0.037). After a median follow-up time of 60 months, 2 patients in group A and 2 ones in group B experienced stone recurrence (2.5% VS 0.9%, P = 0.612). 1 patient in group A experienced stenosis of CBD while stenosis of CBD occurred to 5 ones in group B (1.3% VS 2.2%, P = 0.937).
Conclusions
Simultaneous closure of CBD upon completion of LCBDE could be safely performed among patients ≥ 70 years.
Fishing litter dominates the litter along the beaches of Palk Bay, Southeastern of India
Authors: Krishnan Priyanka , Bilal Mghili , Perumal Karthikeyan , Kabalieshwaran Muthulakshmi , Kabalieshwaran Rajarajeshwaran , Muthuramalingam Subagunasekar , Kolanthasamy Prabhu , Chellaiyan Stella 
Published: December 2022

Abstract

Background: Fishing activity is a major source of marine litter on beaches, but most studies focus on recreational beaches. In this study, we assessed the abundance, composition, source and spatial distribution of marine litter on ten fishing beaches along Palk Bay, on the southeast coast of India. We also used social media to collect data on the impact of fishing litter on marine animals in the study area.
Results: A total of 4,227 marine litter and their average density of 0.70 items/m2 were collected. Plastic (84.54%) is the most abundant in the study area, followed by cloths (7.46%), glass (5.19%), and rubber (3.47%). From the result, the value of CCI ranges from 6.26 to 25.7 indicating that the coast is "moderately clean" to "extremely dirty". The majority of the marine litter collected originated from fishing activity. The most common are string and cord, fishing lines, fishing gear, floats and buoys.
Conclusion: The presence of this type of marine litter can produce serious environmental issues, such as ghost fishing, that impacts a large variety of marine species. A total of 25 of the olive ridley turtles (Lepidochelys olivacea) were entangled in fishing litter between 2018 and 2020. Most of the reported entanglements were due to discarded or lost fishing gear, which shows the importance of managing this type of litter in India. It is important to manage the litter related to the fishing activity by educating fishermen and organizing clean-up campaigns.
Development of Fournier gangrene after chemotherapy despite the absence of anorectal lesions originally: A case report
Authors: Nonaka Kenichi , Kawase Kota , Takagi Kimiaki , Takatsu Yuta , Maniwa Koji , Takao Chika , Komura Minoru , Mushika Yoshinori , Takeuchi Noriyuki , Kato Toshio , Kusakabe Mitsuhiko , Kondo Mitsutaka 
Published: December 2022

Abstract
Background
Fournier’s gangrene is a life-threatening disease because the infected region expands very quickly, the patient easily suffers septic shock, and the mortality rate is high. Usually, Fournier’s gangrene will occur when there is a wound or tumor, from which a specific bacteria intrudes into soft tissue. We encountered a patient with Fournier’s gangrene due to severe myelosuppression after chemotherapy, although there was no initial lesion on the anus and rectum.
Case presentation:
A 54-year-old man with a recurrence of left testicular cancer had been administered chemotherapy. Twelve days later, the patient complained of severe pain around the anus. The following day, the patient went into septic shock. Upon visual inspection, there was dark purple skin discoloration on the left side of the anus. Laboratory data revealed severe neutropenia. Computed tomography revealed a high density of soft tissue on the left side of the anus and gas bubbles in the left femoral ring. We diagnosed the patient with Fournier’s gangrene due to a severe immune suppressive state after chemotherapy. We emergently removed necrotic tissue as much as possible. However, because the patient was in severe sepsis status, he needed careful management in the intensive care unit for 32 days. After the first emergency operation, we performed additive removals several times. Finally, 391 days after the initial surgery, the patient was discharged from our hospital. The tumor has not recurred, and the patient is under outpatient observation in the urology department.
Conclusion
Despite having no anorectal lesions initially, if patients who receive chemotherapy and are in a severe myelosuppressive state complain of severe pain in the perianal area and have a dark purple discoloration of the skin around the anus, the possibility of Fournier's gangrene should be considered.
Chronic Anti-Coagulation Therapy Reduced Mortality In Patients With High Cardiovascular Risk Early In COVID-19 Pandemic
Authors: Zaghloul Mohamed S. , Jammeh Momodou , Gibson Andrew , Luo Suhong , Chadwick-Mansker Kelley , Liu Qianjin , Yan Yan , Zayed Mohamed A. 
Published: December 2022

Abstract
Background: Coronavirus disease 2019 (COVID-19) is associated with provoked thrombo-inflammatory responses. Early in the COVID-19 pandemic this was thought to contribute to hypercoagulability and multi-organ system complications in infected patients. Limited studies have evaluated the impact of therapeutic anti-coagulation therapy (AC) in alleviate these risks in COVID-19 positive patients. Our study aimed to investigate whether long-term therapeutic AC can decrease the risk of multi-organ system complications (MOSC) including stroke, limb ischemia, gastrointestinal (GI) bleeding, in-hospital and intensive care unit death in COVID-19 positive patients during the early phase of the pandemic in the United States.
Methods: A retrospective analysis was conducted of all COVID-19 positive United States Veterans between March 2020 and October 2020. Patients receiving continuous therapeutic AC for a least 30 days prior to or after their initial COVID-19 positive test were assigned to the AC group. Patients who did not receive AC were included in a control group. We analyzed the primary study outcome of MOSC between the AC and control groups using binary logistic regression analysis (Odd-Ratio; OR).
Results: We identified 48,066 COVID-19 patients, of them 879 (1.8%) were receiving continuous therapeutic AC. The AC cohort had significantly worse comorbidities than the control group. On the adjusted binary logistic regression model, therapeutic AC significantly decreased in-hospital mortality rate (OR; 0.67, p = 0.04), despite a higher incidence of GI bleeding (OR; 4.00, p = 0.02). However, therapeutic AC did not significantly reduce other adverse events.
Conclusion: AC therapy reduced in-hospital death early in the COVID-19 pandemic among patients who were hospitalized with the infection. However, it did not decrease the risk of MOSC. Additional trials are needed to determine the effectiveness of AC in preventing complications associated with ongoing emerging strains of the COVID-19 virus.
Post-cesarean section laparoscopic cholecystectomy: a case report
Authors: Abdelmohsen Sarah , Zidan Mohamed , Fahmy Sherif , Baghdady Ahmed 
Published: December 2022

Abstract
Introduction: Laparoscopic cholecystectomy at the time of cesarean section is novel in medicine. It is safe, feasible, and cost-effective.
Case reports: A 29-year-old G3P2+0 woman had two previous cesarean sections. She was pregnant at 32 weeks. The fetus had anencephaly. She had acute cholecystitis. Laparoscopic cholecystectomy done at the time of termination of pregnancy by cesarean section
Discussion: Laparoscopic surgery seems to be safe at the time of a cesarean section. It enables the surgeon to perform surgery through small incisions, lowering the risks of surgical infection, blood loss, and incisional hernia.
Conclusion: As long as the surgeon is highly qualified and experienced, the combination of laparoscopic cholecystectomy immediately post cesarean section in a critical period as acute cholecystitis is effective.
Impact of prescription length supply policy on patient medication adherence in Thailand
Authors: Jarujumrus Inthorn , Taychakhoonavudh Suthira 
Published: December 2022

Abstract
Background
Phramongkutklao Hospital is one of the largest military hospitals in Thailand. Beginning in 2016, an institutional policy was implemented in which medication prescription length was increased from 30 to 90 days. However, there have been no formal investigations into how this policy has impacted medication adherence among patients in hospitals. As such, this study evaluated how prescription length impacted medication adherence among dyslipidemia and type-2 diabetes patients who were treated at Phramongkutklao Hospital.
Methods
This quasi-experimental study compared patients who received prescription lengths of 30 and 90 days based on information recorded in the hospital database between 2014 and 2017. Therein, we used the medication possession ratio (MPR) to estimate patient adherence. Focusing on patients with universal coverage insurance, we employed the difference-in-difference method to examine changes in adherence from before and after policy implementation, then conducted a logistic regression to test for associations between the predictors and adherence.
Results
We analyzed data from a total of 2,046 patients, with equal amounts of 1,023 placed into the control group (no change to 90-day prescription length) and intervention group (change from 30 to 90-day prescription length). First, we found that increased prescription length was associated with 4% and 5% higher MPRs among dyslipidemia and diabetes patients in the intervention group, respectively. Second, we found that medication adherence was correlated with sex, comorbidities, history of hospitalization, and the number of prescribed medications.
Conclusion
Increasing the prescription length from 30 to 90 days improved medication adherence in both the dyslipidemia and type-2 diabetes patients. This shows that the policy change was successful for patients in the hospital considered for this study.
Comprehensive pan-cancer in tumors of human with tumor suppressor ZMYND11 gene
Authors: Huang Jing , Chen Jiaru , Han Cuifang , Fan Yu , Wu Yun , Cao Kun , Li Tao , Zeng Jincheng , Zhang Xiangning , Sun Xuerong , Wu Hongfu , Yu Hongbing 
Published: December 2022

Abstract
Background
ZMYND11 is a reader of histone proteins and plays an important inhibition role in tumor. There is growing evidence to support its importance, but without a pan-cancer analysis, Based on multiple databases, we conducted a comprehensive analysis.
Methods
Tumor data from both The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were a clear relationship observed gene expression of ZMYND11, state of survival, induction of DNA methylation, alterations in genes, contribution to the parameter of protein phosphorylation, lymphocyte immune infiltration, and correlative cellular pathways.
Results
ZMYND11 was under-expressed in the great majority of carcinomas. High expression group of ZMYND11 offers a more favorable prognosis in KIRC, LGG, MESO, LUAD,PRAD,READ,THCA,BRCA, SARC and UVM. Alterations in N304Kfs*33, K345Rfs*43 and N271Tfs*18 occur in structurally important domains of ZMYND11 and was found in prostate, colorectal and breast cancers.In most tumour tissues, ZMYND11 promoter DNA methylation was lower than in normal tissues, and promoter methylation was largely negatively correlated with mRNA expression levels. We observed low levels of phosphorylation at locus 349 protein in KIRC were identified with low total ZNYND11 protein expression. High phosphorylation levels at locus 393 protein in breast cancer with high total ZNYND11 protein expression. ZMYND11 gene expression in human tumors is mostly reflected by positively relation to immune cell infiltration while it is confirmed by positive association with CD8 + T cell. There was a differential expression of ZMYND11 in different immune subtypes. The gene enrichment SOSO2, PJA2 and KIAA1109 may be molecules interacting with ZMYND11.KEGG and GO analysis involving in RNAase II promoter regulation, positive and negative regulation of the RNAase II promoter, positive and negative regulation of DNA transcription, chromatin modification.
Conclusions
This is a comprehensive pan-cancer analysis of the ZMYND11. It describes the role of ZMYND11 in tumour. and highlights a potential target for ZMYND11 in tumour.
Modifiable Contextual Factors and Implementation Processes Associated with Improved Outcomes in the Multisite Spread of a Safety Intervention
Authors: Kaplan Heather C. , Goldstein Stuart L. , Rubinson Claude , Daraiseh Nancy , Zhang Fang , Rodgers Isabelle M. , Dehale Devesh S. , Askenazi David J. , Somers Michael J.G. , Zaritsky Joshua J. , Misurac Jason , Chadha Vimal , Yonekawa Karyn E. , Sutherland Scott , Weng Patricia L. , Walsh Kathleen E. 
Published: December 2022

Abstract
Background: The national spread of safety interventions has been slow and difficult. While it is widely known that hospital contextual features and implementation factors impact spread of evidence-based interventions, there is little prospective research on modifiable factors that impact implementation at multiple sites. Nephrotoxic Injury Negated by Just-in-Time Action (NINJA) is a system-level patient safety intervention that led to a sustained reduction in nephrotoxic medication–associated acute kidney injury (NTMx-AKI) at one hospital. Our objective was to prospectively characterize the association between context and implementation factors and reduction of NTMx-AKI at nine hospitals implementing NINJA, using mixed methods.
Methods: Grounded in i-PARIHS, we used qualitative comparative analysis (QCA) to assess the association between context and implementation factors, measured quarterly by survey, and reduction of NTMx-AKI, measured using statistical process control and ARIMA modeling. Interviews provided an understanding of causal processes underlying associations identified in QCA. Qualitative and quantitative data were collected and analyzed concurrently and then merged.
Results: Five hospitals reduced AKI, four did not. Overall, the collaborative reduced NTMx- AKI by 8 cases per 1000 patient-days per month (95% CI: 14.6-1.4; p=0.018). QCA analysis revealed that hospitals needed to have a baseline AKI rate > 1.0 to reduce NTMx-AKI (Ncon 1.0, Ncov 0.83). In addition, hospitals that reduced NTMx-AKI had either (a) a pharmacist champion and > 2 pharmacists working on NINJA (Scon 1.0, Scov 0.8) or (b) No other organizational priorities causing implementation delays (Scon 1.0, Scov 0.2). Involving quality improvement coordinators or data analysts did not influence success. Qualitative interviews supported these findings and underscored the importance of how the NINJA implementation team integrated with frontline staff.
Conclusions: We identified two different pathways to successful reduction in NTMx-AKI when implementing NINJA. These findings have implications for the future spread of NINJA and suggest an approach to study spread and scale of safety interventions more broadly.
Academic Procrastination: How much does it affect medical students?
Authors: Tengiz Funda İfakat , Çakmak Çağlar , Bakiu Erald , Turan Nuri Dozdar , Demir Serhat , Çakıoğlu Ethem , Tekindal Mustafa Agah 
Published: December 2022

Abstract
Background
Academic procrastination is a complex phenomenon of purposeful delay which university students are well aware of. Furthermore, it has become more important during the Covid-19 pandemic as with computer-based learning. Despite its bad reputation and necessity of self-control in the course of online education, there is a lack of research on academic procrastination among students in Turkey.
Methods
In this study the Turkish version of Tuckman Procrastination Scale (Tv-TPS) was conducted on a sample consisting of 285 medical students from Turkey as a measurement of procrastination and then the relations between their procrastination level, their gender and academic achievements are investigated.
Results
The results indicated a negative correlation between the procrastination level and exam results. Unexpectedly, five questions of the scale appeared to be loaded on a different factor which showed the highest correlation coefficient with the exam results.
Conclusions
Apart from the relations between procrastination and academic achievement, these findings implied that the population and new environmental factors can be an important indicator for the determination of procrastination.