bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human γδ T cells induce CD8+ T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK
Authors: Wang Shengdong , Li Hengyuan , Chen Tao , Zhou Hao , Zhang Wenkan , Lin Nong , Yu Xiaohua , Lou Yu , Li Binghao , Yinwang Eloy , Wang Zenan , Wang Keyi , Xue Yucheng , Qu Hao , Lin Peng , Sun Hangxiang , Teng Wangsiyuan , Mou Haochen , Chai Xupeng , Cai Zhijian , Ye Zhaoming 
Published: January 2023

AbstractHuman Vγ9Vδ2 T cells have attracted considerable attention as novel alternative antigen-presenting cells (APCs) with the potential to replace dendritic cells in antitumor immunotherapy owing to their high proliferative capacity and low cost. However, the utility of γδ T cells as APCs to induce CD8+ T cell-mediated antitumor immune response, as well as the mechanism by which they perform APC functions, remains unexplored. In this study, we found that activated Vγ9Vδ2 T cells were capable of inducing robust CD8+ T cell responses in osteosarcoma cells. Activated γδ T cells also effectively suppressed osteosarcoma growth by priming CD8+ T cells in xenograft animal models. Mechanistically, we further revealed that activated γδ T cells exhibited increased HSP90 production, which fed back to upregulate MyD88, followed by JNK activation and a subsequent improvement in CCL5 secretion, leading to enhanced CD8+ T cell cross-priming. Thus, our study suggests that Vγ9Vδ2 T cells represent a promising alternative APC for the development of γδ T cell-based tumor immunotherapy.
Association of Preoperative Neutrophil‐to‐Lymphocyte Ratio with Postoperative Acute Kidney Injury and Mortality Following Major Noncardiac Surgeries
Authors: Wang Jie , Bi Yaodan , Ma Jun , He Yijun , Liu Bin 
Published: January 2023

AbstractBackgroundAcute kidney injury (AKI) is a major complication that occurs following an operation. Therefore, there is an increasing need to discover new predictors of AKI. We hypothesized that the preoperative neutrophil‐to‐lymphocyte ratio (NLR) was associated with postoperative AKI and in‐hospital mortality following noncardiac surgery.MethodsThis is a retrospective observational study of patients who underwent noncardiac surgery at Sichuan University West China Hospital from 2018 to 2020. Multivariable logistic regression was performed as the major analytic method. In addition, sensitivity and subgroup analyses were performed to validate the results.ResultsA total of 44,065 patients were included in this study. The prevalence of postoperative AKI was 5.62%, and the in‐hospital mortality was 1.58%. Multivariable analysis demonstrated that NLR ≥ 5 was independently associated with the development of postoperative AKI (OR 1.42, 1.24–1.73; P < 0.001) and in‐hospital mortality (OR 2.03, 1.63–2.52; P < 0.001). Similar results were achieved when propensity‐score matching was performed for patients with NLR ≥ 5 and < 5 on the baseline. In stratified analysis, the associations remained persistent in most subgroups. For the sensitivity analysis, we took NLR as a continuous variable and demonstrated the potential linear relationship between NLR and postoperative AKI and mortality.ConclusionsOur results indicated that preoperative NLR is associated with the prevalence of postoperative AKI and in‐hospital mortality that occur after major noncardiac surgery. These findings suggest that NLR has the potential to be a significant correlation biomarker associated with perioperative risk assessment of patients undergoing noncardiac surgeries.
As simple as possible but not simpler?: the case of irrigation modeling at catchment scale in southwestern France
Authors: Soutif-Bellenger Myriam , Thirel Guillaume , Therond Olivier , Villerd Jean 
Published: January 2023

AbstractThe estimation of irrigation water requirements (IWR) amount and timing is crucial for designing water management strategies at the regional scale. Irrigation requirements can be estimated with different types of models: very complex and detailed crop models, agent-based models, or simplified modeling approaches. Because simplified approaches are often preferred, in this study, we evaluate the consequences of using simplified approaches for IWR assessment at a catchment scale and the consequences of various modeling choices, providing information on the uncertainties. To this end, different simple modeling approaches based on the CropWat model are compared with an agent-based approach (MAELIA), which serves as a benchmark. To assess simulations in detail, partial variance is calculated for several indicators characterizing daily simulated irrigation. Our sensitivity analysis, applied over a sub-catchment of the Aveyron River (southwestern France), shows a high variability in simulations produced by CropWat between the modeling assumptions tested, principally explained by the rules for irrigation triggering and the quantification of daily irrigation. The analysis also shows that several simplified approaches are able to reproduce the irrigation simulated by the high-accuracy MAELIA model, but not necessarily corresponding to an optimal irrigation scheme. Hence, this study confirms the possibility of assessing daily irrigation with simplified approaches, but warns about high modeling uncertainties, reflecting uncertainty in effective irrigation practices. This uncertainty can be taken into account by water managers and modelers through the combination of a set of irrigation models.
Wound drainage measurements: a narrative review
Authors: Shih Terri , Park Sarah , Thorlacius Linnea R. , Daveluy Steven , Garg Amit , Goegji Susanne D. , Kirby Joslyn S. , McGrath Barry M. , Riis Peter T. , Villumsen Bente , Zalik Kari , Jemec Gregor B. E. , Hsiao Jennifer L. 
Published: January 2023

AbstractDrainage from chronic wounds can significantly negatively impact a patient’s quality of life. Change in severity of wound drainage is an important measure of treatment efficacy for wounds. This study reviews existing tools used to assess wound drainage. Qualitative drainage tools are overall less burdensome, and however, differences in user interpretation may reduce inter-rater reliability. Quantitative drainage tools enable more reliable comparisons of drainage severity and treatment response between patients but sometimes require equipment to administer, increasing responder burden. Gaps in the current wound drainage measurement landscape are highlighted. Many of the existing scales have not been validated in robust studies. There is also a lack of validated global drainage measurement tools for patients with chronic inflammatory skin disorders with drainage, such as hidradenitis suppurativa or pyoderma gangrenosum. Development of a succinct drainage measurement tool for inflammatory skin diseases where drainage is a prominent symptom will improve monitoring of meaningful treatment response.
DBS in tremor with dystonia: VIM, GPi or both? A review of the literature and considerations from a single-center experience
Authors: Paoli Davide , Mills Russell , Brechany Una , Pavese Nicola , Nicholson Claire 
Published: January 2023

Abstract
Background
Deep brain stimulation (DBS) is an established treatment for dystonia and tremor. However, there is no consensus about the best surgical targeting strategy in patients with concomitant tremor and dystonia. Both the thalamic ventral intermediate nucleus (VIM) and the globus pallidus pars interna (GPi) have been proposed as targets. Few cases using them together in a double-target approach have also been reported.

Methods
We reviewed the literature on this topic, summarizing results of different target choices. Additionally, we retrospectively report a case series of nine patients with sporadic dystonia and severe tremor treated with a double-target strategy at our center. Outcome measures were the Burke-Fahn-Marsden Dystonia Rating Scale (BFM) and Eq-5d scale.

Results
In published studies of patients with dystonia and tremor, VIM-DBS is highly effective on tremor but raise some concerns about dystonia’s control, while GPi-DBS is more effective on dystonia but does not always relieve tremor. GPi + VIM-DBS shows good efficacy but is rarely reported and reserved for selected patients. In our patients, the double-target strategy obtained a significant and durable improvement in tremor, dystonia, and quality of life. Additionally, compared with a cohort of patients with tremor treated with VIM-DBS only, significantly lower frequency and intensity of VIM stimulation were required to control tremor.

Conclusion
Our findings and published evidence seem to support the double-targeting approach as a safe and effective option in selected patients with tremor-dominant dystonia. This strategy appears to provide a more extensive control of either dystonia or tremor and may have a potential for limiting stimulation-related side effects.
Comitant strabismus etiology: extraocular muscle integrity and central nervous system involvement—a narrative review
Authors: Sunyer-Grau Bernat , Quevedo Lluïsa , Rodríguez-Vallejo Manuel , Argilés Marc 
Published: January 2023

Abstract
Strabismus is not a condition in itself but the consequence of an underlying problem. Eye misalignment can be caused by disease, injury, and/or abnormalities in any of the structures and processes involved in visual perception and oculomotor control, from the extraocular muscles and their innervations to the oculomotor and visual processing areas in the brain. A small percentage of all strabismus cases are the consequence of well-described genetic syndromes, acquired insult, or disease affecting the extraocular muscles (EOMs) or their innervations. We will refer to them as strabismus of peripheral origin since their etiology lies in the peripheral nervous system. However, in most strabismus cases, that is comitant, non-restrictive, non-paralytic strabismus, the EOMs and their innervations function properly. These cases are not related to specific syndromes and their precise causes remain poorly understood. They are generally believed to be caused by deficits in the central neural pathways involved in visual perception and oculomotor control. Therefore, we will refer to them as central strabismus. The goal of this narrative review is to discuss the possible causes behind this particular type of eye misalignment and to raise awareness among eyecare professionals about the important role the central nervous system plays in strabismus etiology, and the subsequent implications regarding its treatment. A non-systematic search was conducted using PubMed, Medline, Cochrane, and Google Scholar databases with the keywords “origins,” “causes,” and “etiology” combined with “strabismus.” A snowball approach was also used to find relevant references. In the following article, we will first describe EOM integrity in central strabismus; next, we will address numerous reasons that support the idea of central nervous system (CNS) involvement in the origin of the deviation, followed by listing several possible central causes of the ocular misalignment. Finally, we will discuss the implications CNS etiology has on strabismus treatment.
Influence of cholestasis on portal vein embolization-induced hypertrophy of the future liver remnant
Authors: Chang Xinwei , Korenblik Remon , Olij Bram , Knapen Robrecht R. M. M. , van der Leij Christiaan , Heise Daniel , den Dulk Marcel , Neumann Ulf P. , Schaap Frank G. , van Dam Ronald M. , Olde Damink Steven W. M. 
Published: January 2023

Abstract

Purpose
In the pre-clinical setting, hepatocellular bile salt accumulation impairs liver regeneration following partial hepatectomy. Here, we study the impact of cholestasis on portal vein embolization (PVE)-induced hypertrophy of the future liver remnant (FLR).

Methods
Patients were enrolled with perihilar cholangiocarcinoma (pCCA) or colorectal liver metastases (CRLM) undergoing PVE before a (extended) right hemihepatectomy. Volume of segments II/III was considered FLR and assessed on pre-embolization and post-embolization CT scans. The degree of hypertrophy (DH, percentual increase) and kinetic growth rate (KGR, percentage/week) were used to assess PVE-induced hypertrophy.

Results
A total of 50 patients (31 CRLM, 19 pCCA) were included. After PVE, the DH and KGR were similar in patients with CRLM and pCCA (5.2 [3.3–6.9] versus 5.7 [3.2–7.4] %, respectively, p = 0.960 for DH; 1.4 [0.9–2.5] versus 1.9 [1.0–2.4] %/week, respectively, p = 0.742 for KGR). Moreover, pCCA patients with or without hyperbilirubinemia had comparable DH (5.6 [3.0–7.5] versus 5.7 [2.4–7.0] %, respectively, p = 0.806) and KGR (1.7 [1.0–2.4] versus 1.9 [0.8–2.4] %/week, respectively, p = 1.000). For patients with pCCA, unilateral drainage in FLR induced a higher DH than bilateral drainage (6.7 [4.9–7.9] versus 2.7 [1.5–4.2] %, p = 0.012). C-reactive protein before PVE was negatively correlated with DH (ρ = − 0.539, p = 0.038) and KGR (ρ = − 0.532, p = 0.041) in patients with pCCA.

Conclusions
There was no influence of cholestasis on FLR hypertrophy in patients undergoing PVE. Bilateral drainage and inflammation appeared to be negatively associated with FLR hypertrophy. Further prospective studies with larger and more homogenous patient cohorts are desirable.
Learning motor actions via imagery—perceptual or motor learning?
Authors: Frank Cornelia , Kraeutner Sarah N. , Rieger Martina , Boe Shaun G. 
Published: January 2023

AbstractIt is well accepted that repeatedly imagining oneself acting without any overt behavior can lead to learning. The prominent theory accounting for why imagery practice is effective, motor simulation theory, posits that imagined action and overt action are functionally equivalent, the exception being activation of the end effector. If, as motor simulation theory states, one can compile the goal, plan, motor program and outcome of an action during imagined action similar to overt action, then learning of novel skills via imagery should proceed in a manner equivalent to that of overt action. While the evidence on motor simulation theory is both plentiful and diverse, it does not explicitly account for differences in neural and behavioural findings between imagined and overt action. In this position paper, we briefly review theoretical accounts to date and present a perceptual–cognitive theory that accounts for often observed outcomes of imagery practice. We suggest that learning by way of imagery reflects perceptual-cognitive scaffolding, and that this ‘perceptual’ learning transfers into ‘motor’ learning (or not) depending on various factors. Based on this theory, we characterize consistently reported learning effects that occur with imagery practice, against the background of well-known physical practice effects and show that perceptual-cognitive scaffolding is well-suited to explain what is being learnt during imagery practice.
Prognostic value of baseline and early response FDG-PET/CT in patients with refractory and relapsed aggressive B-cell lymphoma undergoing CAR-T cell therapy
Authors: Georgi Thomas Walter , Kurch Lars , Franke Georg-Nikolaus , Jentzsch Madlen , Schwind Sebastian , Perez-Fernandez Carmen , Petermann Naima , Merz Maximilian , Metzeler Klaus , Borte Gudrun , Hoffmann Sandra , Herling Marco , Denecke Timm , Kluge Regine , Sabri Osama , Platzbecker Uwe , Vučinić Vladan 
Published: January 2023

Abstract
Purpose
Chimeric antigen receptor (CAR)-T cells are a viable treatment option for patients with relapsed or refractory (r/r) aggressive B-cell lymphomas. The prognosis of patients who relapse after CAR-T cell treatment is dismal and factors predicting outcomes need to be identified. Our aim was to assess the value of FDG-PET/CT in terms of predicting patient outcomes.

Methods
Twenty-two patients with r/r B-cell lymphoma who received CAR-T cell treatment with tisagenlecleucel (n = 17) or axicabtagene ciloleucel (n = 5) underwent quantitative FDG-PET/CT before (PET-0) and 1 month after infusion of CAR-T cells (PET-1). PET-1 was classified as complete metabolic response (CMR, Deauville score 1–3) or non-CMR (Deauville score 4–5).

Results
At the time of PET-1, 12/22 (55%) patients showed CMR, ten (45%) patients non-CMR. 7/12 (58%) CMR patients relapsed after a median of 223 days, three of them (25%) died. 9/10 (90%) non-CMR patients developed relapse or progressive disease after a median of 91 days, eight of them (80%) died. CMR patients demonstrated a significantly lower median total metabolic tumor volume (TMTV) in PET-0 (1 ml) than non-CMR patients (225 ml).

Conclusion
Our results confirm the prognostic value of PET-1. 42% of all CMR patients are still in remission 1 year after CAR T-cell treatment. 90% of the non-CMR patients relapsed, indicating the need for early intervention. Higher TMTV before CAR-T cell infusion was associated with lower chances of CMR.
Urban tree composition is associated with breeding success of a passerine bird, but effects vary within and between years
Authors: Jensen Johan Kjellberg , Ekroos Johan , Watson Hannah , Salmón Pablo , Olsson Peter , Isaksson Caroline 
Published: January 2023

AbstractBirds breeding in urban environments have lower reproductive output compared to rural conspecifics, most likely because of food limitation. However, which characteristics of urban environments may cause this deficiency is not clear. Here, we investigated how tree composition within urban territories of passerine birds is associated with breeding probability and reproductive success. We used 7 years of data of breeding occupancy for blue and great tits (Cyanistes caeruleus; Parus major) and several reproductive traits for great tits, from 400 urban nest boxes located in 5 parks within the city of Malmö, Sweden. We found that tits, overall, were less likely to breed in territories dominated by either non-native trees or beech trees. Great tit chicks reared in territories dominated by non-native trees weighed significantly less, compared to territories with fewer non-native trees. An earlier onset of breeding correlated with increased chick weight in great tits. Increasing number of common oak trees (Quercus robur) was associated with delayed onset of breeding in great tits. Notably, as offspring survival probability generally increased by breeding earlier, in particular in oak-dominated territories, our results suggest that delayed onset of breeding induced by oak trees may be maladaptive and indicate a mismatch to this food source. Our results demonstrate that tree composition may have important consequences on breeding success of urban birds, but some of these effects are not consistent between years, highlighting the need to account for temporal effects to understand determinants of breeding success and inform optimal management in urban green spaces.
Computing Dense and Sparse Subgraphs of Weakly Closed Graphs
Authors: Koana Tomohiro , Komusiewicz Christian , Sommer Frank 
Published: January 2023

AbstractA graph G is weakly $$\gamma $$
γ
-closed if every induced subgraph of G contains one vertex v such that for each non-neighbor u of v it holds that $$ \vert N(u)\cap N(v) \vert <\gamma $$

|
N
(
u
)
∩
N
(
v
)
|
<
γ

. The weak closure $$\gamma (G)$$

γ
(
G
)

of a graph, recently introduced by Fox et al. (SIAM J Comput 49(2):448–464, 2020), is the smallest number such that G is weakly $$\gamma $$
γ
-closed. This graph parameter is never larger than the degeneracy (plus one) and can be significantly smaller. Extending the work of Fox et al. (2020) on clique enumeration, we show that several problems related to finding dense subgraphs, such as the enumeration of bicliques and s-plexes, are fixed-parameter tractable with respect to $$\gamma (G)$$

γ
(
G
)

. Moreover, we show that the problem of determining whether a weakly $$\gamma $$
γ
-closed graph G has a subgraph on at least k vertices that belongs to a graph class $$\mathcal {G}$$
G
which is closed under taking subgraphs admits a kernel with at most $$\gamma k^2$$

γ

k
2

vertices. Finally, we provide fixed-parameter algorithms for Independent Dominating Set and Dominating Clique when parameterized by $$\gamma +k$$

γ
+
k

where k is the solution size. Furthermore, we show that Independent Dominating Set does not admit a polynomial kernel for constant $$\gamma $$
γ
under standard assumptions.
Sexual quality of life following a cancer diagnosis: a qualitative study
Authors: Haber Lauren , Allen Andrew , Rune Karina T. 
Published: January 2023

AbstractSexual quality of life (SQoL) challenges are prevalent and persistent for people with a cancer diagnosis. Using a qualitative design, this study investigated the impact of a cancer diagnosis on SQoL in participants (N = 18) with a current or past cancer diagnosis of various sites and severity. Thematic analysis identified three themes: gender attachment, vulnerability, and growth vs. fixed mindset. The theme of gender attachment related to the impact of understanding SQoL based on heteronormative definitions of masculinity and femininity. The second theme of vulnerability suggested that pre-existing relational or personal challenges can amplify the impact of a cancer diagnosis on SQoL. The third theme of growth vs. fixed mindset explored how cognitive flexibility and optimism can support SQoL, while a rigid and pessimistic mindset can exacerbate SQoL challenges. The findings of this study build on the traditional medical understanding of SQoL and can inform SQoL support in cancer care settings.
Anastomosis within and between networks of Rhizophagus irregularis is differentially influenced by fungicides
Authors: Rodriguez-Morelos Victor Hugo , Calonne-Salmon Maryline , Declerck Stéphane 
Published: January 2023

AbstractArbuscular mycorrhizal (AM) fungi play key roles in soil fertility of agroecosystems. They develop dense extraradical mycelial (ERM) networks via mechanisms such as hyphal anastomosis. These connections between hyphae can be affected by agricultural practices such as the use of fungicides, but how these compounds affect anastomosis formation within and more importantly between networks of the same AM fungal strain remains poorly unexplored. Here, the impact of azoxystrobin, pencycuron, flutolanil, and fenpropimorph at 0.02 and 2 mg L−1 were tested in vitro on the anastomosis formation within and between networks of Rhizophagus irregularis MUCL 41833. Azoxystrobin and fenpropimorph had a particularly detrimental impact, at the highest concentration (2 mg L−1), on the number of anastomoses within and between networks, and for fenpropimorph in particular at both concentrations (0.02 and 2 mg L−1) on the number of anastomoses per length of hyphae. Curiously fenpropimorph at 0.02 mg L−1 significantly stimulated spore production, while with azoxystrobin, the reverse was observed at 2 mg L−1. The two other fungicides, pencycuron and flutolanil, had no detrimental effects on spore production or anastomosis formation within and between networks. These results suggest that fungicides with different modes of action and concentrations differentially affect anastomosis possibly by altering the hyphal tips of AM fungi and may thus affect the capacity of AM fungi to develop large hyphal networks exploring and exploiting the soil at the service of plants.