bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Stack Singulation for Technical Textiles Using Sensor Supervised Low Pressure Suction Grippers
Authors: Wirth Benjamin , Schwind Tizian , Friedmann Marco , Fleischer Jürgen 
Published: July 2023

AbstractAutomated handling of technical textiles poses major challenges on modern handling systems. Previous research has shown that using suction grippers is feasible for handling processes involving textiles. However, separating individual sheets of air-permeable materials from a stack using such grippers is a nontrivial task. This paper details an automated stack singulation process using low pressure suction grippers leveraging online data from differential pressure sensors to control the singulation process. Subsystems are analyzed to derive a governing model representation of the process. This model is deployed on a robotic test rig validating the process in experimental analysis. Using this approach, a controlled singulation process for stacked carbon fiber mats has been achieved with a success rate exceeding 99% showing the practicality of controlling the internal suction pressure for advanced handling processes using low pressure suction grippers. Further improvement could be achievable by incorporating and fusing multiple sensor principles.
Insight into Indentation Processes of Ni-Graphene Nanocomposites by Molecular Dynamics Simulation
Authors: Vardanyan V. H. , Urbassek H. M. 
Published: July 2023

AbstractMolecular dynamics simulations provide insight into the processes underlying material plasticity and hard-ness. We demonstrate its uses here for the special case of a metal-matrix nanocomposite, viz. Ni-graphene. A series of increasingly more complex simulation scenarios is established, starting from a single-crystalline matrix over bi-crystal samples to fully polycrystalline arrangements. We find that the nanocomposite is weaker than the single-crystalline metal, since the graphene flakes are opaque to dislocation transmission and thus constrain the size of the dislocation network produced by the indenter. However, the flakes increase the hardness of a polycrystalline metal matrix. This is caused by dislocation pile-up in front of the flakes as well as dislocation absorption (annihilation) by the graphene flakes.
A G-Equivariant String-Net Construction
Authors: DeLazzer Meunier Adrien , Schweigert Christoph , Traube Matthias 
Published: July 2023

AbstractWe develop a string-net construction for the (2,1)-dimensional part of a G-equivariant three-dimensional topological field theory based on a G-graded spherical fusion category. In this construction, a G-equivariant generalization of the Ptolemy groupoid enters. We compute the associated cylinder categories and show that, as expected, the model is closely related to the G-equivariant Turaev–Viro theory.
Magnetic resonance imaging of anal cancer: tumor characteristics and early prediction of treatment outcome
Authors: Hanekamp Bettina A. , Viktil Ellen , Slørdahl Kathinka S. , Dormagen Johann Baptist , Kløw Nils E. , Malinen Eirik , Brunborg Cathrine , Guren Marianne G. , Schulz Anselm 
Published: July 2023

Abstract
Purpose
To analyze tumor characteristics derived from pelvic magnetic resonance imaging (MRI) of patients with squamous cell carcinoma of the anus (SCCA) before and during chemoradiotherapy (CRT), and to compare the changes in these characteristics between scans of responders vs. nonresponders to CRT.

Methods
We included 52 patients with a pelvic 3T MRI scan prior to CRT (baseline scan); 39 of these patients received an additional scan during week 2 of CRT (second scan). Volume, diameter, extramural tumor depth (EMTD), and external anal sphincter infiltration (EASI) of the tumor were assessed. Mean, kurtosis, skewness, standard deviation (SD), and entropy values were extracted from apparent diffusion coefficient (ADC) histograms. The main outcome was locoregional treatment failure. Correlations were evaluated with Wilcoxon’s signed rank-sum test and Pearson’s correlation coefficient, quantile regression, univariate logistic regression, and area under the ROC curve (AUC) analyses.

Results
In isolated analyses of the baseline and second MRI scans, none of the characteristics were associated with outcome. Comparison between the scans showed significant changes in several characteristics: volume, diameter, EMTD, and ADC skewness decreased in the second scan, although the mean ADC increased. Small decreases in volume and diameter were associated with treatment failure, and these variables had the highest AUC values (0.73 and 0.76, respectively) among the analyzed characteristics.

Conclusion
Changes in tumor volume and diameter in an early scan during CRT could represent easily assessable imaging-based biomarkers to eliminate the need for analysis of more complex MRI characteristics.
Räumlich-zeitliche Psychopathologie – deutsche Version der Scale for Space and Time Experience in Psychosis (STEP)
Authors: Hirjak Dusan , Daub Jonas , Brandt Geva A. , Krayem Maria , Kubera Katharina M. , Northoff Georg 
Published: July 2023

ZusammenfassungHistorische Autoren (u. a. Ludwig Binswanger und Eugène Minkowski) postulierten, dass das Erleben von Patient*innen mit psychotischen Störungen durch „Zeitfragmentierung“ charakterisiert ist. Aus klinischer Praxis ist bekannt, dass Patient*innen mit psychotischen Störungen auch unter Schwierigkeiten der räumlichen Wahrnehmung (z. B. Anomalien im Erleben zwischenmenschlicher Distanz und räumlicher Orientierung) leiden. Obwohl diese Veränderungen zu einer Art Abkopplung von der Realität, zu erheblichem Leidensdruck der Betroffenen und Schwierigkeiten im therapeutischen Prozess führen können, wurde das abnorme Erleben von Raum und Zeit bei psychotischen Störungen bisher nicht ausreichend untersucht. Eine mögliche Ursache ist das Fehlen geeigneter und standardisierter Instrumente, die das Erleben von Raum und Zeit bei Patient*innen mit psychotischen Störungen quantifizieren. Auf Basis eines innovativen Konzepts, der sog. „Räumlich-zeitlichen Psychopathologie“ („spatiotemporal psychopathology“, STPP), wurde erstmalig eine Skala zur systematisch-quantitativen Erfassung des räumlichen und zeitlichen Erlebens bei Patient*innen mit psychotischen Störungen entwickelt. In dieser Arbeit wird nun die deutsche Version der Scale for Space and Time Experience in Psychosis (STEP) vorgestellt. Die englische Originalversion der STEP erfasst in 25 Items verschiedene räumliche (14 items) und zeitliche (11 items) Erlebensphänomene. Die STEP zeigt sowohl eine hohe interne Konsistenz (Cronbach’s α = 0,94) als auch einen signifikanten Zusammenhang mit der Positive and Negative Syndrome Scale (PANSS; p < 0,001). Zusammenfassend stellt die hier vorgelegte deutsche Version der STEP-Skala ein wichtiges Messinstrument im deutschsprachigen Raum zur Erfassung des räumlichen und zeitlichen Erlebens bei psychotischen Störungen dar.
The effect of environmental change, planned and unplanned life events on the long-term outcome of common mental disorders
Authors: Tyrer Peter , Duggan Conor , Yang Min , Tyrer Helen 
Published: July 2023

Abstract
Purpose
To examine the nature of positive and negative environmental change on clinical outcome in 210 patients presenting with anxiety and depression and followed up over 30 years.

Methods
In addition to clinical assessments, major environmental changes, particularly after 12 and 30 years, were recorded in all patients by a combination of self-report and taped interviews. Environmental changes were separated into two major groups, positive or negative, determined by patient opinion.

Results
In all analyses positive changes were found to be associated with better outcome at 12 years with respect to accommodation (P = 0.009), relationships (P = 007), and substance misuse (P = 0.003), with fewer psychiatric admissions (P = 0.011) and fewer social work contacts at 30 years (P = 0.043). Using a consolidated outcome measure positive changes were more likely than negative ones to be associated with a good outcome at 12 and 30 years (39% v 3.6% and 30.2% v 9.1%, respectively). Those with personality disorder at baseline had fewer positive changes (P = 0.018) than others at 12 years and fewer positive occupational changes at 30 years (P = 0.041). Service use was greatly reduced in those with positive events with 50–80% more time free of all psychotropic drug treatment (P < 0.001). Instrumental positive change had greater effects than imposed changes.

Conclusions
Positive environmental change has a favourable impact on clinical outcome in common mental disorders. Although studied naturalistically in this study the findings suggest that if harnessed as a therapeutic intervention, as in nidotherapy and social prescribing, it would yield therapeutic dividends.
Dyspareunia and pelvic pain: comparison of mid-urethral sling methods 10 years after insertion
Authors: Lundmark Drca Anna , Alexandridis Vasileios , Andrada Hamer Maria , Teleman Pia , Söderberg Marie Westergren , Ek Marion 
Published: July 2023

Abstract
Introduction and hypothesis
The mid-urethral sling (MUS) has been used for more than 30 years to cure stress urinary incontinence. The objective of this study was to assess whether surgical technique affects the outcome after more than ten years, regarding dyspareunia and pelvic pain.

Methods
In this longitudinal cohort study we used the Swedish National Quality Register of Gynecological Surgery to identify women who underwent MUS surgery in the period 2006–2010. Out of 4348 eligible women, 2555 (59%) responded to the questionnaire sent out in 2020–2021. The two main surgical techniques, the retropubic and the obturatoric approach, were represented by 1562 and 859 women respectively. The Urogenital Distress Inventory-6 (UDI-6) and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12), as well as general questions concerning the MUS surgery, were sent out to the study population. Dyspareunia and pelvic pain were defined as primary outcomes. Secondary outcomes included PISQ-12, general satisfaction, and self-reported problems due to sling insertion.

Results
A total of 2421 women were included in the analysis. Among these, 71% responded to questions regarding dyspareunia and 77% responded to questions regarding pelvic pain. In a multivariate logistic regression analysis of the primary outcomes, we found no difference in reported dyspareunia (15% vs 17%, odds ratio (OR) 1.1, 95% CI 0.8–1.5) or in reported pelvic pain (17% vs 18%, OR 1.0, 95% CI 0.8–1.3) between the retropubic and obturatoric techniques among study responders.

Conclusion
Dyspareunia and pelvic pain 10–14 years after insertion of a MUS do not differ with respect to surgical technique.
Positivstellensätze for semirings
Authors: Schmüdgen Konrad , Schötz Matthias 
Published: July 2023

AbstractIn this paper we develop a number of results and notions concerning Positivstellensätze for semirings (preprimes) of commutative unital real algebras. First we reduce the Archimedean Positivstellensatz for semirings to the corresponding result for quadratic modules. Various applications of the Archimedean Positivstellensatz for semirings are investigated. A general Positivstellensatz with denominators is proved for filtered algebras with semirings. As an application we derive a denominator-free Positivstellensatz for the cylindrical extension of an algebra with Archimedean semiring. A large number of illustrating examples are given.
On cohomological and formal properties of strong Kähler with torsion and astheno-Kähler metrics
Authors: Sferruzza Tommaso , Tomassini Adriano 
Published: July 2023

AbstractWe provide families of compact astheno-Kähler nilmanifolds and we study the behaviour of the complex blowup of such manifolds. We prove that the existence of an astheno-Kähler metric satisfying an extra differential condition is not preserved by blowup. We also study the interplay between Strong Kähler with torsion metrics and geometrically Bott–Chern metrics. We show that Fino–Parton–Salamon nilmanifolds are geometrically-Bott–Chern-formal, whereas we obtain negative results on the product of two copies of primary Kodaira surface, Inoue surface of type$$\mathcal {S}_M$$

S
M

and on the product of a Kodaira surface with an Inoue surface.
Whey and post-frying oil as substrates in the process of microbial lipids obtaining: a value-added product with nutritional benefits
Authors: Wierzchowska Katarzyna , Derewiaka Dorota , Zieniuk Bartłomiej , Nowak Dorota , Fabiszewska Agata 
Published: July 2023

AbstractYarrowia lipolytica has found many biotechnological applications. The species has a number of regulatory mechanisms to maintain cellular homeostasis, enabling biomass growth in complex media. The aim of this study was to evaluate the use of Y. lipolytica yeast as a platform for the simultaneous management of several industrial by-products and the production of microbial lipids with application potential in the chemical and food industries. Batch cultures of KKP 379 strain were conducted in media with post-frying rapeseed oil (PFO) and a by-product of curd cheese production—acid whey. To evaluate the potential of Yarrowia as a nutraceutical, quantitative and qualitative analyses of microbial sterols were carried out along with an assessment of the biomass mineral composition. It was indicated that the composition and content of sterols varied depending on the phase of cell growth in batch culture. During culture in medium with 20% (v/v) whey and 50 g/L PFO, the cellular lipid content reached 39% (w/w). The highest amount of sterols per dry biomass (7.38 mg/g) and cellular lipids (21.08 mg/g) was recorded after 38 h of culture. The dominant was ergosterol 12.10 mg/g (57%). In addition, the composition of carbon and nitrogen sources in the medium affected the content of selected elements in biomass, indicating that substrate modification can be a tool for manipulating the composition of yeast cells. The results of the study showed that the selection of waste substrates is an important factor in regulation of the cellular lipid accumulation efficiency, as well as the content of certain sterols.
Seshadri stratifications and standard monomial theory
Authors: Chirivì Rocco , Fang Xin , Littelmann Peter 
Published: July 2023

AbstractWe introduce the notion of a Seshadri stratification on an embedded projective variety. Such a structure enables us to construct a Newton-Okounkov simplicial complex and a flat degeneration of the projective variety into a union of toric varieties. We show that the Seshadri stratification provides a geometric setup for a standard monomial theory. In this framework, Lakshmibai-Seshadri paths for Schubert varieties get a geometric interpretation as successive vanishing orders of regular functions.
Pretransplant spleen volume and outcome after hematopoietic stem cell transplantation (HSCT) in patients with acute myeloid leukemia (AML)
Authors: Pohlmann Alexander , Bentgens Eva , Schülke Christoph , Kuron David , Reicherts Christian , Marx Julia , Angenendt Linus , Mikesch Jan-Henrik , Lenz Georg , Stelljes Matthias , Schliemann Christoph 
Published: July 2023

Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective treatment modality for patients with acute myeloid leukemia (AML). Here, we investigated the predictive value of spleen volume on outcome parameters and engraftment kinetics after HSCT in a large cohort of AML patients. A total of 402 patients who received their first HSCT between January 2012 and March 2019 were included in this retrospective study. Spleen volume was correlated to clinical outcome and engraftment kinetics. Median follow-up was 33.7 months (95% confidence interval [CI], 28.9–37.4 months). Patients were subdivided based on median spleen volume of 238.0 cm3 (range 55.7–2693.5 cm3) into a small spleen volume (SSV) and a large spleen volume (LSV) group. LSV was associated with inferior overall survival (OS) after HSCT (55.7% vs. 66.6% at 2 years; P = 0.009) and higher cumulative incidence of NRM (28.8% vs. 20.2% at 2 years; P = 0.048). The adjusted hazard ratio for NRM in the LSV group was 1.55 (95% CI, 1.03–2.34). Time to neutrophil or platelet engraftment and the occurrence of acute or chronic graft-versus-host disease (GVHD) were not significantly different between both groups. Higher spleen volume at the time of HSCT was independently linked to adverse outcomes such as inferior OS and higher cumulative incidence of NRM in AML patients after HSCT. Engraftment kinetics and GVHD were not associated with spleen volume.
Long-term outcomes of autologous platelet treatment for optic disc pit maculopathy
Authors: Gklavas Konstantinos , Athanasiou Alexandros , Neubauer Jonas , Lilou Evangelia , Pohl Lisa , Bartz-Schmidt Karl Ulrich , Dimopoulos Spyridon 
Published: July 2023

Abstract
Purpose
Optic disc pits (ODPs) are rare congenital cavitary abnormalities of the optic nerve head, which can lead to serous macular detachments. The aim of this study was to evaluate the long-term efficacy of pars plana vitrectomy (PPV) combined with autologous platelet concentrate (APC) for the treatment of optic disc pit maculopathy (ODP-M).

Methods
A retrospective analysis was performed on eleven eyes of ten patients with ODP-M, who received PPV combined with APC. Nine eyes operated primary, four of which had a repeat surgery also with injection of APC and two eyes underwent a rescue surgery, after they have been operated in another eye center without APC. Morphological and functional results were the main outcome parameters, determined by optical coherence tomography (OCT) and best-corrected visual acuity (BCVA), respectively.

Results
The mean duration of visual loss before surgery was 4.7 ± 3.89 months (range 0–12 months). The mean BCVA increased significantly from 0.82 ± 0.33 logMAR (range 0.4–1.3) preoperatively to 0.51 ± 0.36 logMAR (range 0–1.2) at the last examination (p = 0.0022). A significant morphological improvement was also noticed with decrease of the mean foveal thickness from 935.82 ± 248.48 µm (range 559–1400 µm) preoperatively to 226.45 ± 76.09 µm (range 110–344 µm) at the final examination (p < 0.0001). The patients were followed-up for a mean 65.36 ± 48.81 months (range 1–144 months). Two eyes developed postoperatively a retinal detachment. Cataract surgery was performed in 5 eyes during the follow-up period.

Conclusion
Our study demonstrated that PPV with APC can improve functional and morphological outcomes, both as a primary and a rescue therapy, without any recurrence over a long follow-up period. To the best of our knowledge, this was the longest observation period regarding the use of APC in treatment of ODP-M.
Toward metacognition: subject-aware contrastive deep fusion representation learning for EEG analysis
Authors: Briden Michael , Norouzi Narges 
Published: July 2023

AbstractWe propose a subject-aware contrastive learning deep fusion neural network framework for effectively classifying subjects’ confidence levels in the perception of visual stimuli. The framework, called WaveFusion, is composed of lightweight convolutional neural networks for per-lead time–frequency analysis and an attention network for integrating the lightweight modalities for final prediction. To facilitate the training of WaveFusion, we incorporate a subject-aware contrastive learning approach by taking advantage of the heterogeneity within a multi-subject electroencephalogram dataset to boost representation learning and classification accuracy. The WaveFusion framework demonstrates high accuracy in classifying confidence levels by achieving a classification accuracy of 95.7% while also identifying influential brain regions.
A risk prognostic model for patients with esophageal squamous cell carcinoma basing on cuproptosis and ferroptosis
Authors: Li Jianan , Liu Jixuan , Li Jixian , Feng Alei , Nie Yuanliu , Yang Zhe , Zhang Wentao 
Published: July 2023

Abstract
Background
Cuproptosis, a form of copper-dependent programmed cell death recently presented by Tsvetkov et al., have been identified as a potential therapeutic target for refractory cancers and ferroptosis, a well-known form describing iron-dependent cell death. However, whether the crossing of cuproptosis-related genes and ferroptosis-related genes can introduce some new idea, thus being used as a novel clinical and therapeutic predictor in esophageal squamous cell carcinoma (ESCC) remains unknown.

Methods
We collected ESCC patient data from the Gene Expression Omnibus and the Cancer Genome Atlas databases and used Gene Set Variation Analysis to score each sample based on cuproptosis and ferroptosis. We then performed weighted gene co-expression network analysis to identify cuproptosis and ferroptosis-related genes (CFRGs) and construct a ferroptosis and cuproptosis-related risk prognostic model, which we validated using a test group. We also investigated the relationship between the risk score and other molecular features, such as signaling pathways, immune infiltration, and mutation status.

Results
Four CFRGs (MIDN, C15orf65, COMTD1 and RAP2B) were identified to construct our risk prognostic model. Patients were classified into low- and high-risk groups based on our risk prognostic model and the low-risk group showed significantly higher survival possibilities (P < 0.001). We used the “GO”, “cibersort” and “ESTIMATE” methods to the above-mentioned genes to estimate the relationship among the risk score, correlated pathways, immune infiltration, and tumor purity.

Conclusion
We constructed a prognostic model using four CFRGs and demonstrated its potential clinical and therapeutic guidance value for ESCC patients.
How competition between overlapping generations can influence optimal egg-laying strategies in annual social insects
Authors: Johansson Jacob , Arce Andres N. , Gill Richard J. 
Published: July 2023

AbstractAnnual social insects are an integral functional group of organisms, particularly in temperate environments. An emblematic part of their annual cycle is the social phase, during which the colony-founding queen rears workers that later assist her in rearing sexual progeny (gynes and drones). In many annual social insects, such as species of bees, wasps, and other groups, developing larvae are provisioned gradually as they develop (progressive provisioning) leading to multiple larval generations being reared simultaneously. We present a model for how the queen in such cases should optimize her egg-laying rate throughout the social phase depending on number-size trade-offs, colony age-structure, and energy balance. Complementing previous theory on optimal allocation between workers vs. sexuals in annual social insects and on temporal egg-laying patterns in solitary insects, we elucidate how resource competition among overlapping larval generations can influence optimal egg-laying strategies. With model parameters informed by knowledge of a common bumblebee species, the optimal egg-laying schedule consists of two temporally separated early broods followed by a more continuous rearing phase, matching empirical observations. However, eggs should initially be laid continuously at a gradually increasing rate when resources are scarce or mortality risks high and in cases where larvae are fully supplied with resources at the egg-laying stage (mass-provisioning). These factors, alongside sexual:worker body size ratios, further determine the overall trend in egg-laying rates over the colony cycle. Our analysis provides an inroad to study and mechanistically understand variation in colony development strategies within and across species of annual social insects.