bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residual Risk of Breast Cancer After Bariatric Surgery
Authors: Doumouras Aristithes G. , Lovrics Olivia , Paterson J. Michael , Sutradhar Rinku , Paszat Lawrence , Sivapathasundaram Branavan , Tarride Jean-Eric , Anvari Mehran 
Published: April 2023

ImportanceExcess adiposity confers higher risk of breast cancer for women. For women who have lost substantial weight, it is unclear whether previous obesity confers residual increased baseline risk of breast cancer compared with peers without obesity.ObjectivesTo determine whether there is a residual risk of breast cancer due to prior obesity among patients who undergo bariatric surgery.Design, Setting, and ParticipantsRetrospective matched cohort study of 69 260 women with index date between January 1, 2010, and December 31, 2016. Patients were followed up for 5 years after bariatric surgery or index date. Population-based clinical and administrative data from multiple databases in Ontario, Canada, were used to match a cohort of women who underwent bariatric surgery for obesity (baseline body mass index [BMI] ≥35 with comorbid conditions or BMI ≥40) to women without a history of bariatric surgery according to age and breast cancer screening history. Nonsurgical controls were divided into 4 BMI categories (&amp;lt;25, 25-29, 30-34, and ≥35). Data were analyzed on October 21, 2021.ExposuresWeight loss via bariatric surgery.Main Outcomes and MeasuresResidual hazard of breast cancer after washout periods of 1, 2, and 5 years. Comparisons were made between the surgical and nonsurgical cohorts overall and within each of the BMI subgroups.ResultsIn total, 69 260 women were included in the analysis, with 13 852 women in each of the 5 study cohorts. The mean (SD) age was 45.1 (10.9) years. In the postsurgical cohort vs the overall nonsurgical cohort (n = 55 408), there was an increased hazard for incident breast cancer in the nonsurgical group after washout periods of 1 year (hazard ratio [HR], 1.40 [95% CI, 1.18-1.67]), 2 years (HR, 1.31 [95% CI, 1.12-1.53]), and 5 years (HR, 1.38 [95% CI, 1.21-1.58]). When the postsurgical cohort was compared with the nonsurgical cohort with BMI less than 25, the hazard of incident breast cancer was not significantly different regardless of the washout period, whereas there was a reduced hazard for incident breast cancer among postsurgical patients compared with nonsurgical patients in all high BMI categories (BMI ≥25).Conclusions and RelevanceFindings suggest that bariatric surgery was associated with a reduced risk of developing breast cancer for women with prior obesity equivalent to that of a woman with a BMI less than 25 and a lower risk when compared with all groups with BMI greater than or equal to 25.
Emerging Trends in Soft Electronics: Integrating Machine Intelligence with Soft Acoustic/Vibration Sensors
Authors: Lee Jeng‐Hun , Cho Kang Hyuk , Cho Kilwon 
Published: April 2023

AbstractIn the last decade, soft acoustic/vibration sensors have gained tremendous research interest due to their unique ability to detect broadband acoustic/vibration stimuli, potentializing futuristic applications including voice biometrics, voice‐controlled human–machine‐interfaces, electronic skin, and skin‐mountable healthcare devices. Importantly, to benefit most from these sensors, it is inevitable to use machine learning (ML) to process their output signals; with ML, a more accurate and efficient interpretation of original data is possible. This paper is dedicated to offering an overview of recent advances empowering the development of soft acoustic/vibration sensors and their signal processing using ML. First, the key performance parameters of the sensors are discussed. Second, popular transduction mechanisms for the sensors are addressed, followed by an in‐depth overview of each type, covering materials used, structural designs, and sensing performances. Third, potential applications of the sensors are elaborated and fourth, a thorough discussion on ML is conducted, exploring different types of ML, specific ML algorithms suitable for processing acoustic/vibration signals, and current trends in ML‐assisted applications. Finally, the challenges and potential opportunities in soft acoustic/vibration sensor and ML research are revealed to offer new insights into future prospects in these fields.
Quantum Dots Facilitate 3D Two‐Photon Laser Lithography
Authors: Yu Ye , Prudnikau Anatol , Lesnyak Vladimir , Kirchner Robert 
Published: April 2023

AbstractIn the past two decades, direct laser writing (DLW) technologies have seen tremendous growth. However, strategies that enhance the printing resolution and the development of printing material with assorted functionalities are still sparser than expected. Herein, a cost‐effective method to tackle this bottleneck is presented. Semiconductor quantum dots (QDs) are selected to carry out this task, most importantly via surface chemistry modification to enable their copolymerization with themonomers, resulting in transparent composites. The evaluations indicate that the QDs show great colloidal stability and their photoluminescent properties are well‐preserved. This allows further exploration of the printing characteristics of such composite material. It is shown that in the presence of the QDs, the material provides a much lower polymerization threshold with faster linewidth growth, indicating that the QDs form a synergetic relationship with the monomer and the photoinitiator, widening the dynamic range of the material and thus increasing the writing efficiency for broader fields of applications. Lowering the polymerization threshold reduces the minimum achievable feature size by ≈32%, which is well‐matched with STED‐based (i.e., stimulated‐emission depletion microscopy) methods in writing 3D structures. The study further elucidates the mechanism of the synergetic behavior, further guiding the future development of functional materials for DLW‐related printing technologies.
An Isomeric Solid Additive Enables High‐Efficiency Polymer Solar Cells Developed Using a Benzo‐Difuran‐Based Donor Polymer
Authors: Chen Lu , Yi Jicheng , Ma Ruijie , Ding Lu , Dela Peña Top Archie , Liu Heng , Chen Jian , Zhang Cuifen , Zhao Chaoyue , Lu Wen , Wei Qi , Zhao Bin , Hu Huawei , Wu Jiaying , Ma Zaifei , Lu Xinhui , Li Mingjie , Zhang Guangye , Li Gang , Yan He 
Published: April 2023

AbstractCurrently, nearly all high‐efficiency organic photovoltaic devices use donor polymers based on the benzo‐dithiophene (BDT) unit. To diversify the choices of building blocks for high‐performance donor polymers, the use of benzo‐difuran (BDF) units is explored, which can achieve reduced steric hindrance, stronger molecular packing, and tunable energy levels. In previous research, the performance of BDF‐based devices lagged behind those of BDT‐based devices. In this study, a high efficiency (18.4%) is achieved using a BDF‐based polymer donor, which is the highest efficiency reported for BDF donor materials to date. The high efficiency is enabled by a donor polymer (D18‐Fu) and the aid of a solid additive (2‐chloronaphthalene), which is the isomer of the commonly used additive 1‐chloronaphthalene. These results revealed the significant effect of 2‐chloronaphthalene in optimizing the morphology and enhancing the device parameters. This work not only provides a new building block that can achieve an efficiency comparable to dominant BDT units but also proposes a new solid additive that can replace the widely used 1‐chloronaphthalene additive.
Regulation of Quantum Wells Width Distribution in Quasi‐2D Perovskite Films for High‐Performance Photodetectors
Authors: Zhao Rudai , Guo Lutong , Zhu He , Zhang Ting , Li Pengwei , Zhang Yiqiang , Song Yanlin 
Published: April 2023

AbstractDynamic optimization of the quantum‐well (QW) width distribution in quasi‐2D halide perovskite thin films is an effective approach for tuning the properties of photoelectric devices. Here, that the QWs width distribution in quasi‐2D perovskite films can be controlled only by using hydroiodic acid (HI) as an additive is demonstrated. A uniform distribution of the colloidal particle size in the quasi‐2D perovskite precursor solution is achieved through the formation of soluble iodoplumbate coordination complexes, PbI3− from the reaction of HI with PbI2, resulting in an improved phase purity in the final film. Density functional theory calculations indicate that the ideal n value quasi‐2D perovskite reaction pathway through the PbI3− complex has a lower enthalpy of formation than the random nucleation pathway without the HI additive. Benefiting from this merit, a high‐quality quasi‐2D perovskite film with optimized phase purity delivered a balanced carrier diffusion length and improved carrier mobility. The resultant photodetectors exhibited a light on/off ratio of 50 000, a responsivity of 0.96 A W−1, and a detectivity of 5.7 × 1012 Jones at 532 nm. In addition, the state‐of‐the‐art device maintained more than 80% of its initial photocurrent after 720 h of storage at 30% relative humidity.
Optimization of Projected Phase Change Memory for Analog In‐Memory Computing Inference
Authors: Li Ning , Mackin Charles , Chen An , Brew Kevin , Philip Timothy , Simon Andrew , Saraf Iqbal , Han Jin‐Ping , Sarwat Syed Ghazi , Burr Geoffrey W. , Rasch Malte , Sebastian Abu , Narayanan Vijay , Saulnier Nicole 
Published: April 2023

AbstractPhase change memory (PCM) is one of the most promising candidates for non‐von Neumann based analog in‐memory computing–particularly for inference of previously‐trained deep neural networks (DNN). It is shown that PCM electrical properties can be tuned systematically using a projection liner, which is designed for resistance drift mitigation, in the manufacturable mushroom PCM. A systematic study of the electrical properties‐including resistance values, memory window, resistance drift, read noise, and their impact on the accuracy of large neural networks of various types and with tens of millions of weights is performed. It is sown that the DNN accuracy can be improved by the PCM with liner for both the short term and long term after programming, due to reduced resistance drift and read noise, respectively, despite the trade‐off of reduced memory window. The liner conductance, PCM device characteristics, and network inference accuracy with PCM memory window and reset state conductance is correlated, which allows us to identify the device optimization space to achieve better short term and long term accuracy for large neural networks.
“But I Live Here Too”: Social‐structural stressors, racial discrimination, and resiliency among urban dwelling black emerging adult men
Authors: Taggart Tamara , Sawyer Simone , Andreou Ashley , Kershaw Trace , Milburn Norweeta G. 
Published: April 2023

AbstractFor many Black emerging adult men in the United States, social‐structural stressors rooted in racial discrimination are daily experiences that place them at greater risk for poor health. Emerging adulthood is a critical life course period marked by greater experimentation with health risk behaviors. Although Black men's health vulnerabilities during this period are connected to their social‐structural environments, investigations of these factors among noncollege sampled Black men remain limited. We conduced thirty semi‐structured in‐depth interviews to examine associations between social‐structural challenges and social‐structural resources for resiliency. Interviews were audio‐recorded, transcribed verbatim, and coded using Dedoose web‐based qualitative software. Through open coding, emergent concepts were connected across interviews and major themes were identified. We found three core social‐structural stressors: (1) Racial profiling, (2) neighborhood violence, and (3) lack of economic opportunities, and three resilience factors: (1) Positive social networks, (2) community‐based resources, and (3) safe environments that foster a sense of community. Collectively, these findings provide insight into developing structural‐ and community‐level interventions tailored to bolster resiliency across multiple levels and counteract the social‐structural challenges that young Black men face.
The D409H variant in GBA1: Challenges in predicting the Gaucher phenotype in the newborn screening era
Authors: Gleason Adenrele M. , D'Souza Andrea , Ryan Emory , Grochowsky Angela R. , Carter Camille R. , Goker‐Alpan Ozlem , Lopez Grisel , Tayebi Nahid , Sidransky Ellen 
Published: April 2023

AbstractGaucher disease (GD) is an autosomal recessive disorder resulting from glucocerebrosidase deficiency due to pathologic variants in GBA1. While clinically heterogeneous, GD encompasses three types, non‐neuronopathic (GD1), acute neuronopathic (GD2), and chronic neuronopathic (GD3). Newborn screening (NBS), which has made remarkable inroads in detecting certain diseases before detrimental health consequences and fatality ensues, is now being piloted for GD in several states and countries. Early on, clinical features of GD2 can overlap with GD3; hence, predicting outcome is challenging. As NBS for GD becomes more available, the increased detection of GD in neonates is inevitable. As a result, health care providers and families will be faced with uncertainty with respect to clinical management. Since more severe GBA1 variants are generally associated with neuronopathic GD, there has been an increased dependence on genotypic information. We present an infant detected by NBS with genotype D409H(p.Asp448His)/RecNciI (p.Leu483Pro; p.Ala495Pro;p.Val499=). To assist in genetic counseling, we performed a retrospective review of other patients in our cohort carrying D409H and reviewed the literature. The study illustrates the challenges faced in counseling for infants with neuronopathic GD, even with known GBA1 variants, and the tough management decisions that can ensue from detection in newborns.
2,3′‐Bisindole Synthesis fromo‐(2.2‐Dibromovinyl)aniline ando‐Ethynylaniline
Authors: Li Pengfei , Yang Fanpeng , Song Qingyan , Wang Rongchao , Wang Zhengshen , Zheng Huaiji 
Published: April 2023

AbstractA Pd‐catalyzed coupling reaction fromo‐alkynylanilines ando‐(2,2‐dibromovinyl)anilines for the synthesis of 2,3′‐bisindoles is developed. In which,o‐ethynylaniline was used as 3‐functionalized indole precursor ando‐(2,2‐dibromovinyl)aniline was used as 2‐functionalized indole precursor. This protocol exhibits high efficiency, good functional group tolerance and scalability from easily accessible starting materials.
Self‐Accelerating Diels–Alder Reaction for Preparing Polymers of Intrinsic Microporosity
Authors: Zhang Yuanxing , Tang Qingquan , Li Zi , Zhang Ke 
Published: April 2023

AbstractIt is a formidable challenge in polycondensation to simultaneously construct multiple covalent bonds to prepare double‐stranded polymers of intrinsic microporosity (PIMs) with fused multicyclic linkages. To the best of our knowledge, this is the first study to develop a self‐accelerating Diels–Alder reaction for successfully preparing double‐stranded PIMs with fused multicyclic backbone structures. A self‐accelerating Diels–Alder reaction was developed based on the [4+2] cycloaddition of sym‐dibenzo‐1,5‐cyclooctadiene‐3,7‐diyne (DIBOD) and ortho‐quinone compounds. In this reaction, the cycloaddition of ortho‐quinone with the first alkyne of DIBOD activates the second alkyne, which reacts with ortho‐quinone at a rate constant 192 times larger than that of the original alkyne. Using this self‐accelerating reaction to polymerize DIBOD and spirocyclic/cyclic difunctional ortho‐quinone monomers, a novel stoichiometric imbalance‐promoted step‐growth polymerization method was developed to prepare PIMs. The resultant PIMs possess intrinsic ultramicropores with pore sizes between 0.45 to 0.7 nm, high specific surface areas above 646 m2 g−1, and good H2 separation performance.
A Linear C=Ge=C Heteroallene with a Di‐coordinated Germanium Atom**
Authors: Sugamata Koh , Asakawa Teppei , Hashizume Daisuke , Minoura Mao 
Published: April 2023

AbstractAllenes (>C=C=C<) are classified as cumulated dienes with a linear structure and an sp‐hybridized central carbon atom. We have synthesized and isolated a stable 2‐germapropadiene with bulky silyl substituents. The 2‐germapropadiene allene moiety adopts a linear structure both in the solid state and in solution. An X‐ray diffraction electron‐density‐distribution (EDD) analysis of this 2‐germapropadiene confirmed the linear C=Ge=C geometry with a formally sp‐hybridized germanium atom that bears two orthogonal C=Ge π‐bonds. Based on detailed structural and computational studies, we concluded that the linear geometry of the isolated 2‐germapropadiene most likely arises from the negative hyperconjugation of the silyl substituents at the terminal carbon atoms. The 2‐germapropadiene reacts rapidly with nucleophiles, indicating that the linearly oriented germanium atom is highly electrophilic.
Reversible Ammonium Ion Intercalation/de‐intercalation with Crystal Water Promotion Effect in Layered VOPO4⋅2 H2O**
Authors: Ye Fei , Pang Ruilvjing , Lu Chengjie , Liu Qiang , Wu Yuping , Ma Renzhi , Hu Linfeng 
Published: April 2023

AbstractThe non‐metal NH4+ carrier has attracted tremendous interests for aqueous energy storage owing to its light molar mass and fast diffusion in aqueous electrolytes. Previous study inferred that NH4+ ion storage in layered VOPO4⋅2 H2O is impossible due to the removal of NH4+ from NH4VOPO4 leads to a phase change inevitably. Herein, we update this cognition and demonstrated highly reversible intercalation/de‐intercalation behavior of NH4+ in layered VOPO4⋅2 H2O host. Satisfactory specific capacity of 154.6 mAh g−1 at 0.1 A g−1 and very stable discharge potential plateau at 0.4 V based on reference electrode was achieved in VOPO4⋅2 H2O. A rocking‐chair ammonium‐ion full cell with the VOPO4⋅2 H2O//2.0 M NH4OTf//PTCDI configuration exhibited a specific capacity of 55 mAh g−1, an average operating voltage of about 1.0 V and excellent long‐term cycling stability over 500 cycles with a coulombic efficiency of ≈99 %. Theoretical DFT calculations suggest a unique crystal water substitution process by ammonium ion during the intercalation process. Our results provide new insight into the intercalation/de‐intercalation of NH4+ ions in layered hydrated phosphates through crystal water enhancement effect.
Practical Antibody Recruiting by Metabolic Labeling with Caged Glycans
Authors: Milawati Hersa , Manabe Yoshiyuki , Matsumoto Takuya , Tsutsui Masato , Ueda Yoshihiro , Miura Ayane , Kabayama Kazuya , Fukase Koichi 
Published: April 2023

AbstractWe propose a de novo glycan display approach that combines metabolic labeling and a glycan‐caging strategy as a facile editing method for cell‐surface glycans. This method enables the introduction of antigen glycans onto cancer cells to induce immune responses through antibody recruiting. The caging strategy prevents the capture of α‐rhamnose (an antigen glycan) by endogenous antibodies during the introduction of the glycan to the targeted cell surface, and subsequent uncaging successfully induces immune responses. Therefore, this study proposes a practical method for editing the cell‐surface glycocalyx under promiscuous conditions, such as those in vivo, which paves the way for the development of glycan function analysis and regulation.
Shape‐ and Size‐Tunable Synthesis of Covalent Organic Cages through Rh‐Catalyzed Regioselective [2+2+2] Cycloaddition
Authors: Sato Yu , Abekura Masato , Oriki Tomohiro , Nagashima Yuki , Uekusa Hidehiro , Tanaka Ken 
Published: April 2023

AbstractCovalent organic cages have potential applications in molecular inclusion/recognition and porous organic crystals. Bridging arene units with sp3 atoms enables facile construction of rigid isolated internal vacancies, and various prismatic arene cages have been synthesized by kinetically controlled covalent bond formation. However, the synthesis of a tetrahedral one, which requires twice as much bond formation as prismatic ones, has been limited to a thermodynamically controlled dynamic SNAr reaction, and this reversible covalent bond formation made the resulting cage product chemically unstable. Here we report the Rh‐catalyzed high‐yielding and highly 1,3,5‐selective room temperature [2+2+2] cycloaddition of push‐pull alkynes and its application to the synthesis of chemically stable aryl ether cages of various shapes and sizes, including prismatic and tetrahedral forms. These aryl ether cages are highly crystalline and intertwine with each other to form regular packing structures. Some aryl ether cages encapsulated isolated water molecules in their hydrophobic cavity by hydrogen bonding with the multiple ester moieties.
Total Synthesis of Lucidumone through Convenient One‐pot Preparation of the Tetracyclic Skeleton by Claisen Rearrangement and Subsequent Intramolecular Aldol Reaction
Authors: Kawamoto Yuichiro , Noguchi Naoki , Kobayashi Toyoharu , Ito Hisanaka 
Published: April 2023

AbstractThe total synthesis of lucidumone (1), a Ganoderma meroterpenoid, was accomplished in racemic form from easily prepared 6 and 7 in 10 steps as the longest linear sequence. The synthesis was completed through one‐pot preparation of the tetracyclic core skeleton by Claisen rearrangement followed by an intramolecular aldol reaction. The intramolecular aldol reaction allowed for the stereocontrolled construction of the bicyclo [2.2.2] octane skeleton fused to an indanone structure. The enantioselective total synthesis of 1 was also described via a chiral transfer strategy in the Claisen rearrangement.
Preparation and characterization of photocurable fluorinated polyether‐based reactive inks
Authors: Zhou Yanqiu , Zhang Limin , Zhang Qingyuan , Huang Hui , Peng Rufang , Jin Bo 
Published: April 2023

AbstractPhotocurable polymer provides fast curable properties via ultraviolet (UV) light for 3D‐printed propellants. This work outlines the preparation and characterization of photocurable fluorinated polyether‐based reactive inks. Acrylate‐terminated poly‐2‐((2,2,3,3,3‐pentafluoropropoxy)‐methyl) ethylene oxide (P5F‐AA) was synthesized as photocurable binder through the esterification of acrylic acid, and the terminal hydroxyl group of poly‐2‐((2,2,3,3,3‐pentafluoropropoxy)‐methyl) ethylene oxide (P5F), which was synthesized through cationic ring‐opening polymerization of 2‐((2,2,3,3,3‐pentafluoropropoxy)methyl) oxy‐ethane (PFEE) by using butane diol as initiator. In comparison with P5F, P5F‐AA had a lower glass transition temperature (Tg) of −63.3°C. A new type of photocurable resin, which may be used for additive manufacturing of energetic materials, was prepared via UV radiation in an LED UV curing tank by using P5F‐AA as prepolymer, diphenyl (2,4,6‐trimethyl benzoyl) phosphine oxide (TPO) as photo‐initiator, and tri‐fluoroethyl acrylate (3F‐AA) and 1,6‐hexanediol diacrylate (HDDA) as mono‐ and multifunctional diluents, respectively. When the mass ratio of P5F‐AA/3F‐AA/HDDA binder matrix was 1:1:0.5, the sample exhibited maximal mechanical strength of 6.56 MPa with elongation at break of 13.38%, which was due to the introduction of HDDA effectively increasing the “entanglement” between molecular chains. Thermogravimetric analysis (TGA‐DTG) was utilized to evaluate the ability to decompose thermally of the binder matrix, and the results showed the initial degradation temperature started at nearly 181°C and two consecutive stages in thermal decomposition. Overall, the obtained results from the different techniques suggested that P5F‐AA/3F‐AA/HDDA binder matrix may be a photocurable reactive ink for 3D‐printed propellants, which would provide a certain reference value and guiding importance for design of reactive inks.