bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-related changes in the neural processing of semantics, within and beyond the core semantic network
Authors: Wu Wei , Hoffman Paul 
Published: May 2023

AbstractAgeing is associated with increases in functional activation, which have been interpreted either as compensatory responses to the higher task demands older people experience, or as neural dedifferentiation. Ageing is also characterised by a shift to greater reliance on prior knowledge and less on executive function, whose underlying neural mechanism is poorly understood. This pre-registered fMRI study investigated these questions within the domain of semantic cognition. To disentangle the compensation and dedifferentiation theories, we extracted activation signal in core verbal semantic regions, for young and older participants during semantic tasks. Verbal semantic processing relies heavily on left inferior frontal gyrus (IFG) but older people frequently show additional right IFG activation. We found that right IFG exhibited a similar linear activation-demand relationship as left IFG across age groups and semantic tasks, indicating that age-related over-recruitment of this region may be compensatory in nature. To answer the second question, we examined network-level activity and connectivity changes in semantic and non-semantic tasks. Older people showed more engagement of the default mode network (DMN) and less of the executive multiple demand network (MDN) aligning with their greater reserves of prior knowledge and declined executive control. In contrast, activation was age-invariant in regions contributing specifically to executive control of semantic processing. Older adults also showed a degraded ability to modulate MDN activation as a function of demand in the non-semantic task, but not in the semantic tasks. These findings provide a new perspective on the neural basis of semantic cognition in later life, and suggest that preservation of activation in specialised semantic networks may support preserved performance in this critical domain.
Deciphering the gene regulatory circuitry governing chemoresistance in Triple-Negative Breast Cancer
Authors: Lusby Ryan , Zhang Ziyi , Mahesh Arun , Tiwari Vijay K. 
Published: May 2023

ABSTRACTTriple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, due in part to extensive intratumoral heterogeneity, high rates of metastasis and chemoresistance, leading to poor clinical outcomes. Despite progress, the mechanistic basis of chemotherapy resistance in TNBC patients remains poorly understood. Here, using single-cell transcriptome datasets of matched longitudinal TNBC chemoresponsive and chemoresistant patient cohorts, we discover cell subpopulations associated with chemoresistance and the signature genes defining these populations. Notably, we show that the expression of these chemoresistance genes is driven via a set of TNBC super-enhancers and transcription factor networks across TNBC subtypes. Furthermore, genetic screens reveal that a subset of these transcription factors is essential for the survival of TNBC cells and their loss increases sensitivity to chemotherapeutic agents. Overall, our study has revealed transcriptional regulatory networks underlying chemoresistance and suggests novel avenues to stratify and improve the treatment of patients with a high risk of developing resistance.
Cerebellar nuclei cells produce distinct pathogenic spike signatures in mouse models of ataxia, dystonia, and tremor
Authors: van der Heijden Meike E. , Brown Amanda M. , Kizek Dominic J. , Sillitoe Roy V. 
Published: May 2023

AbstractThe cerebellum contributes to a diverse array of motor conditions including ataxia, dystonia, and tremor. The neural substrates that encode this diversity are unclear. Here, we tested whether the neural spike activity of cerebellar output neurons is distinct between movement disorders with different impairments, generalizable across movement disorders with similar impairments, and capable of causing distinct movement impairments. Usingin vivoawake recordings as input data, we trained a supervised classifier model to differentiate the spike parameters between mouse models for ataxia, dystonia, and tremor. The classifier model correctly assigned mouse phenotypes based on single neuron signatures. Spike signatures were shared across etiologically distinct but phenotypically similar disease models. Mimicking these pathophysiological spike signatures with optogenetics induced the predicted motor impairments in otherwise healthy mice. These data show that distinct spike signatures promote the behavioral presentation of cerebellar diseases.
Downregulation of the silent potassium channel Kv8.1 increases ALS motor neuron vulnerability
Authors: Huang Xuan , Lee Seungkyu , Kawaguchi Riki , Wiskow Ole , Ghosh Sulagna , Frost Devlin , Perrault Laura , Pandey Roshan , Chen Kuchuan , Klim Joseph R. , Boivin Bruno , Hermawan Crystal , Livak Kenneth J. , Geschwind Dan , Wainger Brian J. , Eggan Kevin , Bean Bruce P. , Woolf Clifford J 
Published: May 2023

AbstractThe Kv8.1 potassium ion channel encoded by the KCNV1 gene is a “silent” subunit whose biological function is unknown. In ALS patient-derived motor neurons carrying SOD1(A4V) and C9orf72 mutations, its expression is highly reduced, yielding increased vulnerability to cell death without a change in motor neuronal firing. Our data suggests that Kv8.1 modulates Kv2 channel function to impact neuronal metabolism and lipid/protein transport pathways, but not excitability.
A global meta-analysis of effects of green infrastructure on COVID-19 infection and mortality rates
Authors: Phogole Bopaki , Yessoufou Kowiyou 
Published: May 2023

AbstractEvidence of the benefits of greenspaces or greenness to human wellbeing in the context of COVID-19 is fragmented and sometimes contradictory. This calls for a meta-analysis of existing studies to clarify the matter. Here, we identified 621 studies across the world, which were then filtered down to 13 relevant studies covering Africa, Asia, Europe, and USA. These studies were meta-analysed, with the impacts of greenspaces on COVID-19 infection rate quantified using regression estimates whereas impacts on mortality was measured using mortality rate ratios. We found evidence of significant negative correlations between greenness and both COVID-19 infection and mortality rates. We further found that the impacts on COVID-19 infection and mortality are moderated by year of publication, greenness metrics, sample size, health and political covariates. This clarification has far-reaching implications on policy development towards the establishment and management of green infrastructure for the benefits of human wellbeing.
Performance funding and the academic profession: a New Zealand case study
Authors: Sarpong Joshua 
Published: May 2023

PurposeIn recent times, universities have been faced with the challenge of implementing neoliberal ideas as a survival tactic. For instance, there is increasing pressure on academics globally to publish because of performance funding and other metrics like global rankings, which consider where and how much academics publish. This study explores how neoliberalism in higher education has influenced the academic profession.Design/methodology/approachThe study used two New Zealand universities as case studies to understand how the universities' academics respond to government formula for allocating public funding to universities and also how the universities respond to the changing higher education system in New Zealand. In total, 21 academics were interviewed and documents such as the strategic plans of the universities; policies, guidelines and procedures; Tertiary Education Union reports and media reports were analysed.FindingsThe study finds that neoliberal practices could lead to occupational stress that comes with the pressure to publish, increased teaching workload and casualisation of the academic job, especially amongst emerging academics.Originality/valueWhilst the topic is not entirely original, this study is pertinent and offers the following advice to stakeholders. A university's success is a function of its academics, and academics perform at an exceptional level because academics want to, not because academics are being made to. Unless governments and universities address the intense competition that results from funding allocation procedures, the less well-off academics will fail and some will be forced to compromise the duties that academics have. A collaborative and collegial higher education system that focuses on serving the public good can be an alternative.
Fintech and contactless payment: Help or hindrance? The role of invasion of privacy and information disclosure
Authors: Alalwan Ali Abdallah , Baabdullah Abdullah M. , Al-Debei Mutaz M. , Raman Ramakrishnan , Alhitmi Hitmi Khalifa , Abu-ElSamen Amjad A. , Dwivedi Yogesh K. 
Published: May 2023

PurposeThere is always a need to discover how a paradox between a customer’s desire for a more personalized experience and their privacy and security concerns would shape their intention to continue using contactless payment methods. However, personalization–privacy paradox has not been well-covered over the area of contactless payment. Therefore, this study aims to empirically examine the impact of personalization–privacy paradox on the customers’ continued intention (CIN) to use contactless payment.Design/methodology/approach – The empirical part of the current study was conducted in Saudi Arabia by collecting the primary data using online questionnaire from a convenience sample size of 297 actual users of contactless payment methods.FindingsBased on structural equation modeling, personalization and privacy invasion were approved to significantly impact perceived value of information disclosure (PVD). Strong causal associations were confirmed between perceived severity, structural assurance and response cost with privacy invasion. Finally, both PVD and privacy invasion significantly predict CIN.Research limitations/implicationsThere are other important factors (i.e. technology interactivity, technology readiness, social influence, trust, prior experience, etc.) were not tested in the current study. Therefore, future studies would pay more attention regarding the impact of these factors. The current study data were also collected using a convenience sample of actual users of contactless payment methods. Therefore, there is a concern regarding the generalizability of the current study results to other kind of customers who have not used contactless payment.Originality/valueThis study has integrated both personalization–privacy paradox and protection motivation theory in one model. The current study holds value in providing a new and complete picture of the inhibitors and enablers of customers’ CIN to use contactless payment, including new types of inhibitors. Furthermore, personalization–privacy paradox has not been fully examined over the related area of Fintech and contactless payment in general. Therefore, this study was able to extend the theoretical horizon personalization–privacy paradox to new area (i.e. contactless payment) and new cultural context (Saudi Arabia).
Emotional factors of bra that effect satisfaction and attractiveness
Authors: Wen Xingyu , Zhang Jing , Whang Mincheol 
Published: May 2023

PurposeThe purpose of this paper is to analyze the relationship between affect space and bra design factors based on the observer's vision judgment.Design/methodology/approachFirst, using two dimensions of attractiveness and satisfaction to define the bra emotion space based on literature. Then, the mapping relation between bra design factors and emotional space is analyzed in visual perception. Finally, the model of bra emotion recognition based on design factors is established using the neural network BRP.FindingsUsers' emotions stimulated by bras can be automatically recognized based on their visual design factors. (1) attractiveness and satisfaction which are used to define bra emotions space show a linear correlation between each other in the human visual domain. (2) The design factors that cause attractiveness can also cause satisfaction. However, the factors that stimulate satisfaction do not necessarily attract users' interest, such as the ratio, location of embellishments, hollowed, core decoration and contour lines.Practical implicationsThe analysis of bra emotion space may help designers to understand the relationship between bra visual appearance and emotion, and ask them to pay attention to empathic design factors. With the provided results, designers can also carry out and evaluate emotional bra design with high attractiveness and satisfaction.Originality/valueThis paper discusses the emotional attributes of bra visual design factors based on bra emotion space and explores the methods of bra emotion design.
Awareness and perception of the environmental sustainability of the UAE University campus: a case study of sustainability course
Authors: Albattah Mohammed , Bande Lindita 
Published: May 2023

Purpose
This study aims to investigate the entry-level student’s awareness of environmental sustainability focussing on the United Arab Emirates University (UAEU) campus and measure the effectiveness of the course materials. A comparison between the students who took the general education sustainability (GESU 121) course face to face and the ones who tool it online was applied.

Design/methodology/approach
This study was descriptive in nature, and the data is obtained using a cross-sectional survey of the students attending the UAEU in 2020. The data collection was done in two semesters, Spring 2020 [face-to-face class] and Fall 2020 [online class, after COVID-19 effect]. A total of 160 participants responded to the survey. The Pearson’s Chi-square test for independence was conducted and used to identify if any statistical differences exist between the studied variables.

Findings
This study revealed that the awareness of environmental sustainability was increased in both groups [face-to-face students and online students], after taking the course. In addition, around 80% of the students were interested to participate in sustainability initiatives on the UAEU campus. The students’ perception of the statements about the UAEU campus environmental sustainability varied from Spring 2020 (53.3% were not sure that the UAEU campus is environmentally sustainable) to Fall 2022 (63% of the online students believed that the campus is environmentally sustainable).

Originality/value
Students’ awareness and perception are very important to improve the environmental sustainability of the University campus. The novelty of this study is to examine the awareness of entry-level students among the environmental sustainability focussing on the UAEU campus and examine the effect of COVID-19 [online classes] on delivering the course knowledge. The findings of this study provide the information for the improvement of the course for the future semesters.
Values and interventions: dynamic relationships in international doctrines
Authors: Lin Mi , Pereira Roders Ana , Nevzgodin Ivan , de Jonge Wessel 
Published: May 2023

PurposeEven if there is a wealth of research highlighting the key role of values and cultural significance for heritage management and, defining specific interventions on built heritage, seldom the relation to their leading values and values hierarchy have been researched. How do values and interventions relate? What values trigger most and least interventions on heritage? How do these values relate and characterize interventions? And what are the values hierarchy that make the interventions on built heritage differ?Design/methodology/approachThis paper conducts a systematic content analysis of 69 international doctrinal documents – mainly adopted by Council of Europe, UNESCO, and ICOMOS, during 1877 and 2021. The main aim is to reveal and compare the intervention concepts and their definitions, in relation to values. The intensity of the relationship between intervention concepts and values is determined based on the frequency of mentioned values per intervention.FindingsThere were three key findings. First, historic, social, and aesthetical values were the most referenced values in international doctrinal documents. Second, while intervention concepts revealed similar definitions and shared common leading values, their secondary values and values hierarchy, e.g. aesthetical or social values, are the ones influencing the variation on their definitions. Third, certain values show contradictory roles in the same intervention concepts from different documents, e.g. political and age values.Originality/valueThis paper explores a novel comparison between different interventions concepts and definitions, and the role of values. The results can contribute to support further research and practice on clarifying the identified differences.
Shariah governance disclosure and its effect on Islamic banks' financial performance: evidence from Malaysia and GCC countries
Authors: Abdul Rahim Memiyanty , Shaharuddin Nur ’Ain Syahirah , Mohd Suki Norazah 
Published: May 2023

Purpose
The purpose of this study is to examine the level of Shariah governance disclosure among Islamic banks in Malaysia and the Gulf Cooperation Council (GCC) countries (i.e. Kuwait, Bahrain, United Arab Emirates, Qatar, Oman and Saudi Arabia). On top of that, the effect of Shariah governance disclosure on Islamic banks financial performance is investigated.

Design/methodology/approach
Data underwent quantitative content analysis and a mean comparison of the Shariah governance disclosure mechanisms as well as multiple regression analysis. Shariah governance information is obtained from the Islamic banks' official websites and the Bursa Malaysia Exchange.

Findings
The results of the content analysis revealed that the level of Shariah governance disclosure among Malaysian Islamic banks has been more pronounced than in the GCC countries. Additionally, the multiple regression analysis results specified that of the five Shariah governance disclosure mechanisms, the Shariah committee emerged as the strongest determinant in the financial performance of the Islamic banks, followed by transparency and disclosure.

Practical implications
Islamic banks should emphasise publishing Shariah governance information in annual reports to reflect superior accounting practices as assessed by certified Shariah auditors with an effective monitoring system.

Originality/value
The empirical findings are vital for serving as a guideline for Islamic banks in Malaysia and the GCC countries to disclose their practice of Shariah governance and gain empirical insights into its effect on firms’ financial performance. Following that, Islamic banks would improve their accounting practices while adhering to Shariah principles, strengthen internal controls and boost their brand reputation.
A case study in innovation policymaking: standard contracts as a tool to improve university–industry collaboration
Authors: George A.J. , Tarr Julie-Anne 
Published: May 2023

Purpose
To increase university–industry collaboration and research commercialisation, the Australian government recently introduced the Intellectual Property (IP) Framework, a set of online standard contracts. This follows a predecessor standard contract initiative, the IP Toolkit, which has not previously been evaluated. This paper aims to examine standard contracting in the innovation sector, tracing the policymaking behind the IP Toolkit using the lens of Macneil’s relational contract theory, to assess prospects of success for the new IP Framework, and similar initiatives in other jurisdictions.

Design/methodology/approach
This is a disciplined-configurative case study, drawing on qualitative secondary data analysis and applying Macneil’s relational contracting theory to guide case construction and generate hypotheses around likely success of standard contracting initiatives (stakeholder sentiment, stakeholder adoption). Within-case analysis process-traces development of the IP Toolkit, to discover what the policymakers wanted, knew and computed – and to detail observable implications Macneil’s theory predicts. Its themes are triangulated with multiple sources.

Findings
The case study, via Macneil’s theory, confirms the first hypothesis (resistant stakeholder sentiment) and partly validates the second hypothesis (low levels of adoption), demonstrating limited suitability of standard contracting in the dynamic and highly uncertain space of university–industry collaboration.

Research limitations/implications
The study provides insights into the limited role that standard contracts can play in improving national collaborative research and development performance.

Originality/value
This is a novel theory-driven case study triangulated with previously unpublished data on the IP Toolkit’s website usage, and data from recent consultations on the new IP Framework. It has broader implications for other jurisdictions considering adoption of the standard contract model.
Citation Gecko technology for research and entrepreneurship
Authors: Gupta Varun 
Published: May 2023

Purpose
This study aims to investigate how Citation Gecko technology might help libraries provide better research support services. The paper explains specifically how Citation Gecko can help libraries provide more precise and thorough references, save time and enable methodical literature reviews and scoping studies amid the constantly evolving nature of research domains. The paper also considers how businesses and libraries can gain from implementing the technology.

Design/methodology/approach
The paper’s conceptual study of the function of librarians in assisting researchers – particularly in the setting of exhaustive literature reviews and scoping studies – forms the foundation of the piece. The authors talk about the difficulties in guaranteeing the authenticity and comprehensiveness of the literature review process and the significance of adopting tools like Citation Gecko to help with this process. The possible adoption of Citation Gecko in libraries is also forecasted using the technological adoption model paradigm.

Findings
Libraries that use Citation Gecko technology provide better research support services by providing accurate and comprehensive references, saving time and assisting systematic literature surveys and scoping studies. The tool is simple to use and does not require professional training due to its user-friendly interface and ability to produce references fast. Using Citation Gecko technology can enhance libraries’ capacities to support researchers, faculty and students in their research projects by making a significant contribution to systematic surveys and referencing efforts.

Originality/value
This study adds to the continuing discussion about how libraries may use technology to improve the services they provide to users who need research support. It had never been looked into how citation Gecko might help libraries with their reference and systematic review study offerings.