bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flexible 3D printed microwires and 3D microelectrodes for heart-on-a-chip engineering
Authors: Wu Qinghua , Zhang Peikai , O’Leary Gerard , Zhao Yimu , Xu Yinghao , Rafatian Naimeh , Okhovatian Sargol , Landau Shira , Valiante Taufik A , Travas-Sejdic Jadranka , Radisic Milica 
Published: May 2023

Abstract
We developed a heart-on-a-chip platform that integrates highly flexible, vertical, 3D micropillar electrodes for electrophysiological recording and elastic microwires for the tissue’s contractile force assessment. The high aspect ratio microelectrodes were 3D-printed into the device using a conductive polymer, poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS). A pair of flexible, quantum dots/thermoplastic elastomer nanocomposite microwires were 3D printed to anchor the tissue and enable continuous contractile force assessment. The 3D microelectrodes and flexible microwires enabled unobstructed human iPSC-based cardiac tissue formation and contraction, suspended above the device surface, under both spontaneous beating and upon pacing with a separate set of integrated carbon electrodes. Recording of extracellular field potentials using the PEDOT:PSS micropillars was demonstrated with and without epinephrine as a model drug, non-invasively, along with in situ monitoring of tissue contractile properties and calcium transients. Uniquely, the platform provides integrated profiling of electrical and contractile tissue properties, which is critical for proper evaluation of complex, mechanically and electrically active tissues, such as the heart muscle under both physiological and pathological conditions.
Effect of Ar-plasma treatment and annealing on thermally evaporated β-In2S3 thin films
Authors: Rasool S , Saritha K , Reddy K T Ramakrishna , Tivanov M S , Korolik O V , Gremenok V F , Zimin S P , Amirov I I 
Published: May 2023

Abstract
In the present study, the effect of annealing and Ar-plasma treatment on structural, morphological and optical properties of thermally evaporated β-In2S3 thin films has been investigated. During Ar-plasma treatment, some interesting results were observed that an array of metallic indium nanostructures was formed over In2S3 film surface with quasi-spherical or spread droplet shapes of an average size of 20–100 nm in the lateral direction and a height of less than 70 nm. Here, the Ar-plasma treatment serves as a new strategy for the self-formation of metallic indium nanostructures over the film surface. Further, the optical absorption of In2S3 films has been enhanced from 104 to 107 cm−1 while the optical band gap energy decreased from 2.71 eV to 2.50 eV after Ar-plasma treatment. The metallic nanostructures loaded on semiconductor surface can act as an electron trap that can effectively prevent the recombination of photo-generated electron-hole pairs.
Experimental overview for green printed electronics: inks, substrates, and printing techniques
Authors: Batet David , Vilaseca Fabiola , Ramon Eloi , Esquivel Juan Pablo , Gabriel Gemma 
Published: May 2023

Abstract
The selection of materials and technologies for green printed electronics design is a fundamental and time-consuming task. This paper represents a rigorous experimental overview in which different printing technologies, ink formulations, and paper-based substrates are examined and analyzed. Three printing techniques are investigated: inkjet printing, screen printing, and direct ink writing. Regarding the inks, formulations based on carbon and silver have been chosen as conductive materials. Initially, the electrical properties of the selected inks have been characterized on a conventional substrate in printed electronics such as polyethylene terephthalate. Later, the printing conditions are optimized for various paper-based substrates, including commercial papers and substrates based on cellulose nanofibers (CNF). CNF are also used as a coating for commercial papers and their influence on the printing quality is evaluated. The substrates are also characterized in terms of morphology, wettability, and thermal stability. This study facilitates the benchmarking tasks for researchers developing new devices and contributes toward the eco-design of flexible green printed electronics.
Towards the construction of an accurate kinetic energy density functional and its functional derivative through physics-informed neural networks
Authors: Rincón Luis , Seijas Luis E , Almeida Rafael , Javier Torres F 
Published: May 2023

Abstract
One of the primary obstacles in the development of orbital–free density functional theory is the lack of an accurate functional for the Kohn–Sham non-interacting kinetic energy, which, in addition to its accuracy, must also render a good approximation for its functional derivative. To address this critical issue, we propose the construction of a kinetic energy density functional throught physical- informed neural network, where the neural network’s loss function is designed to simultaneously reproduce the atom’s shell structures, and also, an analytically calculated functional derivative. As a proof-of-concept, we have tested the accuracy of the kinetic energy potential by optimizing electron densities for atoms from Li to Xe.
Targeting new ways for large-scale, high-speed surface functionalization using direct laser interference patterning in a roll-to-roll process
Authors: Zwahr Christoph , Serey Nicolas , Nitschke Lukas , Bischoff Christian , Rädel Ulrich , Meyer Alexandra , Zhu Penghui , Pfleging Wilhelm 
Published: May 2023

Abstract
Direct Laser Interference Patterning (DLIP) is used to texture current collector foils in a roll-to-roll process using a high-power picosecond pulsed laser system operating at either fundamental wavelength of 1064 nm or 2nd harmonic of 532 nm. The raw beam having a diameter of 3 mm @ 1/e
2 is shaped into an elongated top-hat intensity profile using a diffractive so-called FBS®-L element and cylindrical telescopes. The shaped beam is split into its diffraction orders, where the two first orders are parallelized and guided into a galvanometer scanner. The deflected beams inside the scan head are recombined with an F-theta objective on the working position generating the interference pattern. The DLIP spot has a line-like interference pattern with about 15 μm spatial period. Laser fluences of up to 8 J cm−2 were achieved using a maximum pulse energy of 0.6 mJ. Furthermore, an in-house built roll-to-roll machine was developed. Using this setup, aluminum and copper foil of 20 μm and 9 μm thickness, respectively, could be processed. Subsequently to current collector structuring coating of composite electrode material took place. In case of lithium nickel manganese cobalt oxide (NMC 622) cathode deposited onto textured aluminum current collector, an increased specific discharge capacity could be achieved at a C-rate of 1 °C. For the silicon/graphite anode material deposited onto textured copper current collector, an improved rate capability at all C-rates between C/10 and 5 °C was achieved. The rate capability was increased up to 100% compared to reference material. At C-rates between C/2 and 2 °C, the specific discharge capacity was increased to 200 mAh g−1, while the reference electrodes with untextured current collector foils provided a specific discharge capacity of 100 mAh g−1, showing the potential of the DLIP technology for cost-effective production of battery cells with increased cycle lifetime.
Development of a roll-to-roll high-speed laser micro processing machine for preparing through-holed anodes and cathodes of lithium-ion batteries
Authors: Yamada Mitsuru , Soma Naohiko , Tsuta Masaya , Nakamura Susumu , Ando Nobuo , Matsumoto Futoshi 
Published: May 2023

Abstract
Aiming to improve the battery performance of lithium-ion batteries (LIBs), modification of the cathodes and anodes of LIBs using laser beams to prepare through-holes, non-through-holes or ditches arranged in grid and line patterns has been proposed by many researchers and engineers. In this study, a laser processing system attached to rollers, which realizes this modification without large changes in the present mass-production system, was developed. The laser system apparatus comprises roll-to-roll equipment and laser equipment. The roll-to-roll equipment mainly consists of a hollow cylinder with openings on its circumferential surface. Cathode and anode electrodes for LIBs are wound around the cylinder in the longitudinal direction of the electrodes. A pulsed beam reflected from the central axis of the cylinder can continuously open a large number of through-holes in the thin electrodes. Through-holes were formed at a rate of 100 000 holes per second on lithium iron phosphate cathodes and graphite anodes with this system. The through-holed cathodes and anodes prepared with this system exhibited higher C-rate performance than nontreated cathodes and anodes.
Bolzano on aesthetic normativity
Authors: Lopes Dominic McIver 
Published: May 2023

Abstract
A theory of aesthetic normativity states what makes it the case that the fact that an item is beautiful is reason to appreciate it. Aesthetic hedonists characteristically hold that the fact that an item is beautiful is reason to appreciate it because anyone always has reason to do what yields pleasure. Bernard Bolzano was an aesthetic hedonist who is best interpreted as offering a mixed theory of aesthetic normativity.The fact that an item is beautiful is reason to appreciate it because anyone always has reason to do what yields pleasure and because anyone also has reason to do what fosters virtue, the capacity to act well. The argument for this interpretation knits together Bolzano’s aesthetics, his ethics, and his philosophy of science. In doing so, this argument opens up a new perspective on aesthetic normativity.
Lessons Learned From Integrating Anti-Oppression Pedagogy in a Graduate-Level Course in Epidemiology
Authors: Lyons Vivian H , Seiler Jessie , Rowhani-Rahbar Ali , Adhia Avanti 
Published: May 2023

Abstract
Despite the high burden of injury and violence globally and disproportionate burden on marginalized communities, few US schools of public health and departments of epidemiology offer classes focused on injury and violence, and even fewer are taught with an antiracist or anti-oppression framework. Recent years have brought renewed focus to incorporating antiracist and anti-oppression principles to pedagogy. Public health professionals have increasingly grappled with how we teach, conduct research, and advocate for just policies, which are shaped by interlocking systems of oppression. Although all areas of epidemiology are shaped by these structures, motivations for those who study injury and violence ought to be especially keen. In this commentary, we illustrate how anti-oppression can be integrated into course development and delivery with a case study of a graduate-level course at the University of Washington School of Public Health on injury and violence epidemiology. We include feedback from an epidemiology faculty reviewer, as well as narratives from students describing what worked and what did not. We offer our reflections and lessons learned, hoping to encourage others within public health and epidemiology to adopt an anti-oppression framework in developing classes and programs, particularly those related to injury and violence.
SNAP Participation and Medication Adherence Among Older Black Medicaid-Insured Individuals Living With Hypertension
Authors: Ojinnaka Chinedum O , Arteaga Irma , Hodges Leslie , Heflin Colleen 
Published: May 2023

Abstract

BACKGROUND
Black people are more likely to be diagnosed with hypertension and to experience food insecurity and antihypertensive medication non-adherence compared to White people in the U.S. The Supplemental Nutrition Assistance Program (SNAP)—a means-tested program that targets food insecurity has been shown to affect health outcomes. This study analyzed the relationship between SNAP participation and antihypertensive medication adherence among older Black Medicaid-insured individuals.

METHODS
This is a retrospective cohort study using linked 2006–2014 state of Missouri Medicaid and SNAP administrative claims data. Analyses were restricted to older (≥60 years) Black individuals who were continuously enrolled in Medicaid for 12 months following their first observed claim for hypertension at or after age 60 years with at least one pharmacy claim (n = 10,693). Our outcome measure is a dichotomous measure of antihypertensive medication adherence defined using the Proportion of Days Covered (≥80% PDC = 1). The exposure variables are four measures of SNAP participation.

RESULTS
A higher proportion of SNAP participants were adherent to their antihypertensive medications compared to non-SNAP participants (43.5% vs. 32.0%). On multivariable analyses, compared to non-SNAP participants there was an increased likelihood of antihypertensive medication adherence among SNAP participants (prevalence ratio [PR] = 1.25; 95% confidence interval [CI] = 1.16–1.35). Compared to those who participated in SNAP for 1–3 months during the 12-month continuous enrollment, there was an increased likelihood of antihypertensive medication adherence among those who were enrolled for 10–12 months (PR = 1.41; 95% CI = 1.08–1.85).

CONCLUSIONS
Medicaid-insured older Black adults who were SNAP participants had a higher likelihood of antihypertensive medication adherence compared to non-SNAP participants.
Outpatient-Based High-Volume Liposuction: A Retrospective Review of 310 Consecutive Patients
Authors: Golpanian Samuel , Rahal George A , Rahal William J 
Published: May 2023

Abstract

Background
Currently, the definition of large-volume liposuction is the removal of 5 L or more of total aspirate. Higher volumes of lipoaspirate come into consideration with higher BMIs, because more than 5 L is often required to achieve a satisfactory aesthetic result. The boundaries of what lipoaspirate volume is considered safe are based on historical opinion and are constantly in question.

Objectives
Because to date there have been no scientific data available to support a specific safe maximum volume of lipoaspirate, the authors discuss necessary conditions for safe high-volume lipoaspirate extraction.

Methods
This retrospective study included 310 patients who had liposuction of ≥5 L over a 30-month period. All patients had 360° liposuction alone or in combination with other procedures.

Results
Patient ages ranged from 20 to 66 with a mean age of 38.5 (SD = 9.3). Average operative time was 202 minutes (SD = 83.1). Mean total aspirate was 7.5 L (SD = 1.9). An average of 1.84 L (SD = 0.69) of intravenous fluids and 8.99 L (SD = 1.47) of tumescent fluid were administered. Urine output was maintained above 0.5 mL/kg/hr. There were no major cardiopulmonary complications or cases requiring blood transfusion.

Conclusions
High-volume liposuction is safe if proper preoperative, intraoperative, and postoperative protocols and techniques are employed. The authors believe that this bias should be modified and that sharing their experience with high-volume liposuction may help guide other surgeons to incorporate this practice with confidence and safety for better patient outcomes.

Level of Evidence: 3
Studies on biosynthetic enzymes leading to structural and functional diversity of microbial natural products
Authors: Dairi Tohru 
Published: May 2023

ABSTRACT
The primary metabolic pathways, for the most part, have been disclosed in Escherichia coli and Saccharomyces cerevisiae. These pathways were believed to be common among all microorganisms. However, after discovery of an alternative pathway for biosynthesis of isopentenyl diphosphate, the methylerythritol phosphate pathway, genome mining of alternative biosynthetic pathways for primary metabolites has been performed. My collaborators and I focused on the biosynthetic pathways of menaquinone and peptidoglycan because some microorganisms lack ortholog genes of the known biosynthetic pathways for these compounds. I also studied biosynthetic enzymes for secondary metabolites produced by actinomycetes and fungi because they include many unique enzymes. In this review, outlines of these studies are described.
GraphscoreDTA: optimized graph neural network for protein–ligand binding affinity prediction
Authors: Wang Kaili , Zhou Renyi , Tang Jing , Li Min 
Published: May 2023

AbstractMotivationComputational approaches for identifying the protein–ligand binding affinity can greatly facilitate drug discovery and development. At present, many deep learning-based models are proposed to predict the protein–ligand binding affinity and achieve significant performance improvement. However, protein–ligand binding affinity prediction still has fundamental challenges. One challenge is that the mutual information between proteins and ligands is hard to capture. Another challenge is how to find and highlight the important atoms of the ligands and residues of the proteins.ResultsTo solve these limitations, we develop a novel graph neural network strategy with the Vina distance optimization terms (GraphscoreDTA) for predicting protein–ligand binding affinity, which takes the combination of graph neural network, bitransport information mechanism and physics-based distance terms into account for the first time. Unlike other methods, GraphscoreDTA can not only effectively capture the protein–ligand pairs’ mutual information but also highlight the important atoms of the ligands and residues of the proteins. The results show that GraphscoreDTA significantly outperforms existing methods on multiple test sets. Furthermore, the tests of drug–target selectivity on the cyclin-dependent kinase and the homologous protein families demonstrate that GraphscoreDTA is a reliable tool for protein–ligand binding affinity prediction.Availability and implementationThe resource codes are available at https://github.com/CSUBioGroup/GraphscoreDTA.
Insulin-like growth factor 1 promotes the gonadal development of Pampus argenteus by regulating energy metabolism
Authors: Li Yaya , Li Chang , Fu Yangfei , Wang Ruixian , Yang Yang , Zhang Man , Zhang Youyi , Wang Xiangbing , Wang Guanlin , Jiang Huan , Zou Yushan , Hu Jiabao , Guo Chunyang , Wang Yajun 
Published: May 2023

Abstract
Insulin-like growth factor 1 (Igf1) is known to promote ovarian maturation by interacting with other hormones. However, the limited research on the role of Igf1 in the energy metabolism supply of gonads has hindered further exploration. To explore the role of Igf1 in gonadal development of silver pomfret, we analyzed the expression levels and the localization of igf1 mRNA and protein during testicular and ovarian development of silver pomfret. The results of the study showed upregulation of Igf1 in the critical period of vitellogenesis and sperm meiosis, which was found to be mainly expressed in the somatic cells of the gonads. Upon adding E2 and Igf1 to cultured gonadal tissues, the expression of energy-related genes was significantly increased, along with the E2-enhanced effect of Igf1 in the testis. Importantly, stimulation of both ovaries and testes with E2 and Igf1 led to a remarkable increase in the expression of vitellogenesis and meiosis-related genes. Therefore, we conclude that Igf1 promotes vitellogenesis and sperm meiosis by regulating gonadal energy production. Moreover, the expression of Igf1 in gonads is significantly regulated by E2. These findings provide new insights for the research of Igf1 in fish breeding, thus allowing the regulation of energy metabolism between growth and reproduction for successful reproductive outcomes.
One-step targeted maximum likelihood estimation for targeting cause-specific absolute risks and survival curves
Authors: Rytgaard H C W , van der Laan M J 
Published: May 2023

SummaryThis paper considers the one-step targeted maximum likelihood estimation methodology for multi-dimensional causal parameters in general survival and competing risk settings where event times take place on the positive real line and are subject to right censoring. We focus on effects of baseline treatment decisions possibly confounded by pretreatment covariates, but remark that our work generalizes to settings with time-varying treatment regimes and time-dependent confounding. We point out two overall contributions of our work. First, our methods can be used to obtain simultaneous inference for treatment effects on multiple absolute risks in competing risk settings. Second, our methods can be used to achieve inference for the full survival curve, or a full absolute risk curve, across time. The one-step targeted maximum likelihood procedure is based on a one-dimensional universal least favourable submodel for each cause-specific hazard that we implement in recursive steps along a corresponding nonuniversal multivariate least favourable submodel. Our empirical study demonstrates the practical use of the methods.
Familiarity with Evidence-Based Practice and Self-Evaluated Service Quality: The Mediating Roles of Preference for Authority-Based Evidence and Professional Autonomy
Authors: Li Xiao , Tan Ling , Sun Xiaoyue 
Published: May 2023

Abstract
Evidence-based practice (EBP) is a model that integrates research, education and practice. Although it has been generally promoted and applied in various practice settings, few studies have examined whether EBP is related to service quality in social work. In this study, a sample of 2,987 licensed social workers was drawn from the Chinese Social Workers Survey, and a model that connects familiarity with the EBP process and service quality was tested. Additionally, this study examined the influences of anti-authority culture and professional autonomy on self-perceived service quality. Results showed that the preference for authority-based evidence is prevalent amongst the social workers in this sample. Familiarity with the EBP process is positively related to self-evaluated service quality. Preference for authority-based evidence and professional autonomy partially mediates the relationship between familiarity with the EBP and self-evaluated service quality. These findings provide insights into the EBP process amongst Chinese social workers. Educational implications include promoting high-quality evidence and emphasising critical thinking and accountability in EBP education.
Summary
This study drew a sample of 2987 licensed social workers from the Chinese Social Workers Survey and tested a model that connects familiarity with EBP process and self-evaluated service quality. The findings revealed that the respondents who are more familiar with the EBP process are more likely to report better service quality Chinese social workers' self-reported service quality is partially built on the professional autonomy and anti-authority culture promoted by the EBP movement.
Digitalisation of Indian smart cities: post-Covid-19 approaches to data, recognition and health monitoring
Authors: Krishnan Sneha 
Published: May 2023

Abstract
There is a proliferation of digitalisation of urban and health services in India under the Smart City and Digital Health missions, respectively. This study brings digital and feminist geographies together to understand the role of technologies in urban areas, particularly in health service delivery and how healthcare workers mediate these health platforms. Using a case study of Varanasi city in Uttar Pradesh, India this study documents whether—and to what extent—digital technologies and services enable citizens and service providers to access and improve their lived experiences. The findings indicate a top-down, innovation-focussed model is adopted which excludes and alienates different user groups and citizens shaping their interaction and access to these services.