bluuebunny/crossref_metadata_2025_split huggingface dataset:
L-Arginine abrogates maternal and pre-pubertal codeine exposure-induced impaired spermatogenesis and sperm quality by modulating the levels of mRNA encoding spermatogenic genes
Authors: Akhigbe Roland Eghoghosoa , Afolabi Oladele A. , Ajayi Ayodeji Folorusho 
Published: July 2023

IntroductionAlthough, codeine has been demonstrated to lower sperm quality; the effects of maternal and prepubertal codeine exposure on male offspring is yet to be reported. In addition, the effect of arginine on codeine-induced decline in sperm quality has not been explored. This study investigated the impact of maternal and prepubertal codeine exposure on spermatogenesis and sperm quality in F1 male Wistar rats to study the effect that codeine may have during recreational use in humans. Also, the effect of arginine supplementation on codeine-induced alteration in spermatogenesis and sperm quality was evaluated.MethodsFemale rats were treated with either 0.5 ml distilled water or codeine orally for eight weeks, and then mated with male rats (female:male, 2:1). The F1 male offsprings of both cohorts were weaned at 3 weeks old and administered distilled water, codeine, arginine, or codeine with arginine orally for eight weeks.ResultsPrepubertal codeine exposure in rats whose dams (female parents) were exposed to codeine delayed puberty and reduced the weight at puberty. Prepubertal codeine exposure exacerbated maternal codeine exposure-induced reduced total and daily spermatid production, sperm count, sperm motility, and normal sperm form, as well as impaired sperm plasma membrane integrity and increased not intact acrosome and damaged sperm DNA integrity. These perturbations were accompanied by a decrease in mRNA levels encoding spermatogenic genes, testicular testosterone and androgen receptor (AR) concentrations, and upregulation of sperm 8-hydroxydeoxyguanosine (8OHdG). Prepubertal arginine supplementation mitigated codeine-induced alterations.DiscussionThis study provides novel experimental evidence that maternal and prepubertal codeine exposure reprogramed spermatogenesis and sperm quality of male FI generation by decreasing mRNA levels encoding spermatogenic genes and AR via oxidative stress-mediated signaling, which was abrogated by prepubertal arginine supplementation.
An open-label randomized controlled trial of leflunomide in patients with acute SARS-CoV-2 omicron variant infection
Authors: Pan Zhou , Wan Zhihui , Wang Yixuan , Zha Shiqian , Zhang Jingyi , Chen Hao , Hu Ke 
Published: July 2023

ObjectiveTo evaluate the efficacy and safety of leflunomide for the treatment of acute, symptomatic COVID-19.MethodsA single-center, open-label, randomized controlled trial was performed during an outbreak of SARS-CoV-2 Omicron variant in December 2022. Symptomatic patients within 5 days of COVID-19 onset were randomly allocated to receive 5 days of either symptomatic treatment with leflunomide or symptomatic treatment alone. The primary endpoint was time to sustained clinical recovery.ResultsFifty-seven participants were randomized into two groups: 27 received leflunomide plus symptomatic treatment and 30 were assigned to symptomatic treatment alone. Participants treated with leflunomide had a shorter fever duration [3.0 interquartile range (IQR, 2.0–4.0) days and 4.0 (IQR, 3.0–6.0) days, respectively (p = 0.027)] and reduced viral shedding [7 (IQR, 6–9.5) days and 9.0 (IQR, 7.5–12.0) days, respectively (p = 0.044)] compared with individuals treated with symptomatic treatment alone. However, there were no significant differences in time to sustained clinical recovery between the two groups [hazard ratio, 1.329 (95% confidence interval, 0.878–2.529); p = 0.207].ConclusionIn acute adult COVID-19 patients presenting within 5 days of symptom onset, leflunomide combined with symptomatic treatment reduced fever duration and viral shedding time.Clinical Trial Registrationhttps://www.chictr.org.cn/about.html, ChiCTR2100051684.
Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer’s disease
Authors: Jullienne Amandine , Szu Jenny I. , Quan Ryan , Trinh Michelle V. , Norouzi Tannoz , Noarbe Brenda P. , Bedwell Amanda A. , Eldridge Kierra , Persohn Scott C. , Territo Paul R. , Obenaus Andre 
Published: July 2023

IntroductionThe 5xFAD mouse is a popular model of familial Alzheimer’s disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements. Despite numerous studies, the 5xFAD mouse has not been comprehensively phenotyped for vascular and metabolic perturbations over its lifespan.MethodsMale and female 5xFAD and wild type (WT) littermates underwent in vivo18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging at 4, 6, and 12 months of age to assess regional glucose metabolism. A separate cohort of mice (4, 8, 12 months) underwent “vessel painting” which labels all cerebral vessels and were analyzed for vascular characteristics such as vessel density, junction density, vessel length, network complexity, number of collaterals, and vessel diameter.ResultsWith increasing age, vessels on the cortical surface in both 5xFAD and WT mice showed increased vessel length, vessel and junction densities. The number of collateral vessels between the middle cerebral artery (MCA) and the anterior and posterior cerebral arteries decreased with age but collateral diameters were significantly increased only in 5xFAD mice. MCA total vessel length and junction density were decreased in 5xFAD mice compared to WT at 4 months. Analysis of 18F-FDG cortical uptake revealed significant differences between WT and 5xFAD mice spanning 4–12 months. Broadly, 5xFAD males had significantly increased 18F-FDG uptake at 12 months compared to WT mice. In most cortical regions, female 5xFAD mice had reduced 18F-FDG uptake compared to WT across their lifespan.DiscussionWhile the 5xFAD mouse exhibits AD-like cognitive deficits as early as 4 months of age that are associated with increasing Aβ deposition, we only found significant differences in cortical vascular features in males, not in females. Interestingly, 5xFAD male and female mice exhibited opposite effects in 18F-FDG uptake. The MCA supplies blood to large portions of the somatosensory cortex and portions of motor and visual cortex and increased vessel length alongside decreased collaterals which coincided with higher metabolic rates in 5xFAD mice. Thus, a potential mismatch between metabolic demand and vascular delivery of nutrients in the face of increasing Aβ deposition could contribute to the progressive cognitive deficits seen in the 5xFAD mouse model.
Effect of web-implemented exercise interventions on depression and anxiety in patients with neurological disorders: a systematic review and meta-analysis
Authors: Zhang Hanyue , Wang Rong , Kong Zhenxing , Yu Jingjing , Hou Xiao , Zhang Shouwei 
Published: July 2023

IntroductionWeb-implemented exercise intervention is the latest and innovative method to improve people's mental health. Currently, many studies have proven that web-implemented interventions are effective to improve depression and anxiety in adults. However, the influence of different web-implemented exercise interventions on depression and anxiety in patients with neurological disorders is still unclear.ObjectiveThe study aims to systematically summarize the type and content of web-implemented exercise interventions and quantify the effect of different web-implemented exercise interventions on depression and anxiety in patients with neurological disorders.MethodsFour literature databases (PubMed, Web of Science, China National Knowledge Infrastructure, and WanFang data) were searched. The literature search considered studies published in English or Chinese before October 13, 2022. Randomized controlled trials (RCTs) that participants accepted web-implemented interventions were included. Two authors independently extracted data and assessed the risk of bias for included studies. Standardized mean differences (SMD) with 95% CI were used to integrate the effect size.Results16 RCTs (a total of 963 participants) were included. The results showed that web-implemented exercise intervention had a significant effect on depression (SMD = −0.80; 95% CI, −1.09 to −0.52; I2 = 75%; P &lt; 0.00001) and anxiety (SMD = −0.80; 95% CI, −1.23 to −0.36; I2 = 75%; P = 0.0003) in patients with a neurological disorder. The subgroup analysis showed that the effectiveness of the web-implemented exercise intervention was influenced by several factors, such as web-implemented exercise intervention type, component, and intervention duration.ConclusionWeb-implemented exercise intervention has a relieving effect on depression and anxiety symptoms in patients with neurological disorders. Additionally, the intervention type, intervention duration, and component can influence the effect size.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, identifier: CRD42023409538.
Time discrimination and change detection could share a common brain network: findings of a task-based fMRI study
Authors: Goena Javier , Alústiza Irene , Vidal-Adroher Cristina , Garcés María Sol , Fernández Miguel , Molero Patricio , García-Eulate Reyes , Fernández-Seara María , Ortuño Felipe 
Published: July 2023

IntroductionOver the past few years, several studies have described the brain activation pattern related to both time discrimination (TD) and change detection processes. We hypothesize that both processes share a common brain network which may play a significant role in more complex cognitive processes. The main goal of this proof-of-concept study is to describe the pattern of brain activity involved in TD and oddball detection (OD) paradigms, and in processes requiring higher cognitive effort.MethodsWe designed an experimental task, including an auditory test tool to assess TD and OD paradigms, which was conducted under functional magnetic resonance imaging (fMRI) in 14 healthy participants. We added a cognitive control component into both paradigms in our test tool. We used the general linear model (GLM) to analyze the individual fMRI data images and the random effects model for group inference.ResultsWe defined the areas of brain activation related to TD and OD paradigms. We performed a conjunction analysis of contrast TD (task &gt; control) and OD (task &gt; control) patterns, finding both similarities and significant differences between them.DiscussionWe conclude that change detection and other cognitive processes requiring an increase in cognitive effort require participation of overlapping functional and neuroanatomical components, suggesting the presence of a common time and change detection network. This is of particular relevance for future research on normal cognitive functioning in the healthy population, as well as for the study of cognitive impairment and clinical manifestations associated with various neuropsychiatric conditions such as schizophrenia.
Challenges and countermeasures of China’s research on “sports promoting adolescent socialization”–data mining based on Weibo and CNKI
Authors: Jiang Yueyan , Tao Baole , Lu Tianci , Yan Jun 
Published: July 2023

ObjectiveUnderstand the public demand for Adolescent socialization, and compare the hot spots in the researches of “sports promoting Adolescent socialization,” so as to clarify the high-quality development direction of sports promoting Adolescent socialization in the new era.MethodsCollected the Weibo texts about “Adolescent socialization” from April 13, 2017 to June 1, 2022 through python, and used LDA to understand the relevant hot spots. Used City space to collect CNKI studies related to “sports promote Adolescent socialization,” and used keyword co-occurrence network to understand hot spots.ResultsA total of 77,900 original Weibo texts were captured. The theme model identified five potential themes: “School and Family Education,” “Social Participation,” “Community Education,” “Ideological and Political Education” and “Media.” The semantic network showed that the public concerns of each theme include “Adolescent socialization education content,” “relevant policies and regulations,” “Adolescent socialization environment,” “traditional culture” and “publicity ways and examples”0.52 studies were finally retrieved. The keyword co-occurrence network showed that keywords such as “Adolescent,” “Socialization,” “Sports Games,” “School Sports” and “Family Sports” appeared more frequently and had higher intermediary centrality. Researches focused on Socialization, Internet Addiction, Coupling, School Sports, Sports Socialization Media.ConclusionThe public’s attention to “Adolescent socialization” has three characteristics: subject linkage, object susceptibility, and media diversity. The researches on “Sports Promoting the socialization of Adolescents” has some problems, such as the imbalance of subject supply and demand, the inconsistent way of object supply and demand, and the different content of media supply and demand. The reason is that there is an information island between people and scholars. Existing research results can not meet the demands of the public.
Salivary testosterone and cortisol levels in borderline personality disorder before and after a 12-week group dialectical behavior therapy intervention
Authors: Dyson Tori , Thomas Susan J. , Townsend Michelle L. , Finch Adam , South Alexandra , Barkus Emma , Walter Emma , Mendonca Carley , Grenyer Brin F. S. , Pickard Judy A. 
Published: July 2023

BackgroundBorderline Personality Disorder (BPD) is a chronic, debilitating, and difficult to treat condition. BPD has recently been linked to steroid hormone dysregulation and medical conditions characterized by disturbed androgen metabolism. This study aimed to investigate cortisol and testosterone levels in BPD, and changes in hormones following psychological treatment.MethodsParticipants with BPD (n = 33) completed a 12-week Dialectical Behavior Therapy group program. Pre and post salivary testosterone and cortisol were analyzed. Baseline hormones in the BPD group were compared to age-and-sex matched controls (n = 33). Non-parametric tests were utilized to investigate group differences, pre-post treatment hormone and symptom changes, and associations between symptoms and hormone levels.ResultsParticipants with BPD had significantly higher testosterone levels than controls. Mean testosterone levels in females with BPD were double that of female controls. Testosterone and cortisol levels were related, and some BPD symptoms were associated with with hormone levels. BPD symptoms reduced significantly with treatment, however pre to post hormone levels did not change.ConclusionsThis study supports an association between BPD symptoms and neuroendocrine dysfunction at baseline, however we found no reduction in hormone dysfunction post treatment. Further research into relationships between stress signaling and neuroendocrine disturbances in BPD may inform aetiological and treatment models.Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12618000477224. Registered on 3 April 2018.
Neuropsychological correlates of ADHD: indicators of different attentional profiles among youth with sluggish cognitive tempo
Authors: Krone Beth , Bédard Anne-Claude V. , Schulz Kurt , Ivanov Iliyan , Stein Mark A. , Newcorn Jeffrey H. 
Published: July 2023

ObjectiveThis study examined the distinctiveness of Attention Deficit Hyperactivity Disorder—Inattentive (ADHD-I) and ADHD in context of Sluggish Cognitive Tempo (ADHD + SCT) utilizing the Attention Network Test (ANT) and Continuous Performance Test (CPT) as external validators. Due to the SCT characteristics of being sluggish, spacey, and slow to arouse, we hypothesized that SCT behavioral descriptors would be uniquely related to alerting/arousal mechanisms that the ANT is uniquely designed to capture, and that ADHD symptoms would be more highly associated with cognitive control on the CPT.MethodWe examined associations between baseline ANT and CPT scores for N = 137 well-characterized, culturally and racially diverse youth with ADHD (n = 107) either medication naïve or washed out prior to testing and typically developing controls (n = 30) ages 6–17 years.ResultsPresence and severity of SCT were associated with ANT Alerting (r2 = −.291, p = .005), but not with ANT Orienting, ANT Executive Control, or any CPT measures. There was a distinct association between the presence and severity of ADHD inattention symptoms with CPT T-scores for Commission Errors (r2 = .282, p = .002), Omission Errors (r2 = .254, p = .005), Variability (r2 = .328, p &lt; .001), and Hit Rate SE (r2 = .272, p = .002), but not with other CPT or any ANT domain measures. All associations remained significant after Bonferroni correction.ConclusionsThe small but enduring double dissociation, with ADHD-I symptom severity related to measures of cognitive and behavioral control measures on the CPT, and SCT symptom severity related to attentional processes underlying tonic arousal in preparation for cue detection on the ANT—provides the first objective evidence suggestive of partial neurocognitive independence of SCT from ADHD. Moreover, it points to possibly distinguishable neurobiological neurocognitive underpinnings of the two conditions.
Hubungan Pembelajaran Online Dengan Kejadian Stres Pada Mahasiswa Di Fakultas Ilmu Kesehatan Universitas Islam As-Syafi’iyah Pada Masa Pandemi Covid-19
Authors: Tianti Ade Ajeng , Idris Muhamad 
Published: July 2023

Based on the circular letter of the Ministry of Education and Culture (Kemendikbud) Directorate of Higher Education No. 1 year 2020 during the covid-19 pandemic, universities eliminated teaching and learning activities on campus and shifted them to distance learning (online). In online learning at the Faculty of Health Sciences As-Syafi'iyah Islamic University the implementation of online lectures raises several obstacles such as the internet network and assignments that become stressors for students. The purpose of the study was to determine the relationship between online learning and the incidence of stress in students at the Faculty of Health Sciences, As-Syafi'iyah Islamic University during the Covid-19 pandemic. The research method used descriptive correlation with a cross sectional approach, a population of 184 students consisting of semesters 2, 4, and 6. The sample uses the slovin formula to 65 students taken by proportional sampling technique. The analysis used univariate and biavariate using Chi-Square test = 5% (0.05). The results of the univariate analysis (%) showed a good picture of online learning 55.4% and the incidence of stress was 43.1%, bivariate analysis obtained p or Asym values. Sig. (2-sided) = 0.209 with a value of = 5% (0.05). The conclusion is that there is no relationship between online learning and the incidence of stress in students at the Faculty of Health Sciences, As-Syafi'iyah Islamic University during the Covid-19 pandemic. Suggestions are that students are expected to be more active in class forums such as asking about material that has not been understood and activating the zoom camera.
The Influence Of Organizational Culture, Work Discipline, And Organizational Citizenship Behavior On Organizational Commitment
Authors: Suherdi Suherdi , Ahmad Ahmad 
Published: July 2023

This study aims to examine the influence of organizational culture, work discipline, and organizational citizenship behavior on organizational commitment and can make a theoretical and practical contribution to understanding the concept of organizational commitment. This research was conducted in five sub-districts in the Southern Region, Lebak Regency, and Banten Province. Meanwhile, the research period was from February to May 2020. The random sampling technique was used in this study, and the total number of respondents was 66. This study uses a quantitative survey research method using regression analysis techniques using SPSS version 20 software. Employee organizational commitment will increase as a result of organizational citizenship behavior.
Effect Of Price, Product Quality and Service On Vario 150 Motorcycle Sales at Tunas Honda Pramuka Dealer Bandar Lampung
Authors: Putra Chandra Almer , Mega Selfia Alke 
Published: July 2023

PT Astra Honda Motor is a company in charge of manufacturing, assembling and distributing Honda type and brand motorcycles. This company is a company in Indonesia that has rights as an ATPM or Sole Agent for Honda motorcycles. 2001, Knowing that there are limited abilities and time, researchers only see and need to provide clear and focused problem boundaries. So that the problem is limited to discussing only the influence of price, product quality and service on sales of the Honda Vario 150 motorbike at the Honda Tunas Pramuka dealer in Bandar Lampung. In this study using a quantitative method in which the sample in this study amounted to 45 respondents, the analysis technique used was the classical assumption test, multiple linear regression test, with the results of the study that there was an influence between Price on Sales of 25.71%, then the influence between Quality Product on Sales is 69.05%, then the influence between Service on Sales is 39.31% and the influence of the variables Price, Product Quality and Service on Sales is 1.3%. The results of this study are variable X1 (Price), variable X2 (Quality of Products) and variable X3 (Service) significantly influence Sales (Y), of 1.3%, which means that these three variables influence each other and influence one another.
La Administración Empresarial y la Utilización del Tik Tok Como Parte De Las Estrategias de Marketing Digital
Authors: Campines Barría Francisco Javier , Rodríguez de Tyler Carmen Cecilia , Tyler Rodríguez Cristian Enrrique 
Published: July 2023

El objetivo del estudio es diagnosticar el uso y manejo de la red social Tik Tok como parte de las estrategias de marketing digital de la administración empresarial de almacenes para el incremento de las ventas. La metodología empleada para esta investigación tiene un enfoque mixto, de tipo descriptiva. El diseño de la investigación es no experimental, de corte transversal. La técnica seleccionada para la recolección de datos ha sido por medio de una encuesta aplicada de forma directa a administrativos de los diferentes comercios. La población investigada estuvo conformada por 20 empresas de almacenes ubicadas en el distrito de Santiago, provincia de Veraguas. La muestra la conforma toda la población. Los resultados demuestran que ttres cuartas partes de los almacenes encuestados si utilizan la red social Tik Tok dentro de sus estrategias de marketing empresarial. El 100% de las empresas que utilizan Tik Tok, lo aprovechan para publicitar productos y servicios, mismos indican que ha influido bastante en las ventas.