bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral radicular cyst mimicking dentigerous cyst: a case report
Authors: Anjani Khamila Gayatri , Putri Annisa , Epsilawati Lusi 
Published: December 2022

Objectives: The aim of this case report is to describe radiographically the specific features of periapical cysts to differentiate them from dentigerous cyst lesions despite their similar clinical appearance.
Case Report: A 21-year-old female patient came to Dental Hospital in Bandung with a referral for a cone-beam computed tomography (CBCT) examination with a clinical diagnosis of suspected right mandibular dentigerous cyst and left mandibular periapical cyst. The patient said that during the past month, swelling had appeared on both sides of the jaw, which was getting bigger, the pain was intermittent, and it was disturbing when eating. Intraoral examination showed gingival enlargement, muccobucal fold disappeared. Extraoral examination, facial asymmetry was found due to unilateral swelling. Radiographic examinations showed both lesions were oval, unilocular, radiolucent internal structures with an average density of 4.7-32 HU resembling soft tissue density, corticated or radiopaque borders, caused expansion of the mandibular corpus buccally and lingually and to mesial and distal, cortical thinning and displacement of the inferior mandibular canal.
Conclusion: Lesions on the jaws have almost the same clinical appearance, but through CBCT examination the type of lesion can be well determined. Periapical cyst lesion with large size has a clinical appearance like dentigerous lesions, but radiographically will show a different specific picture.
Mandibular quality assessment in women aged 40-60 years using mandibular cortical index and antegonial index on panoramic radiographs
Authors: Sarifah Norlaila , Hamdani Riky , Nurrahman Tri 
Published: December 2022

Objectives: This study aimed to describe the cortical quality of the mandible in women aged 40-60 years by analyzing the mandibular cortical index and antegonial index on panoramic radiographs.
Materials and Methods: This study was a cross-sectional analytic descriptive study, population, and sample using secondary data on panoramic radiographs of women aged 40-60. The descriptive analysis technique used in this study was the average value (mean), standard deviation, and thickness of the mandibular cortex in radiographs of female patients aged 40-60 years.
Results: This study observed variations in mandibular cortical bone quality on panoramic radiographs, with increasing age, bone quality tends to decrease, and there is an effect of gender involvement. Women tend to have lower bone quality, one of which is due to hormonal factors. This study observed variations in mandibular cortical bone quality on panoramic radiographs, with increasing age, bone quality tends to decrease, and there is an effect of gender involvement. Women tend to have lower bone quality, one of which is due to hormonal factors. The age group at risk of osteoporosis had the lowest mandibular cortex width value in the age group of 51-60 years.
Conclusion: This study produced a variety of panoramic radiographs of the mandibular cortical bone quality. The value of the width of the mandibular cortex gradually decreases with age. The value of mandibular cortex width is higher in the younger generation.
Infectious complications of the respiratory tract and lungs in patients with post-COVID syndrome
Authors: Yakovenko О.К. , Lynnyk М.І. , Іgnatieva V.І. , Gumeniuk G.L. , Opimakh S.G. , Polianska M.A. , Zvol I.V. , Moskalenko S.M. 
Published: December 2022

BACKGROUND. The mechanism of development of post-COVID syndrome is not fully understood. Long-term retention of complaints in patients is associated with long-term persistence of the virus, hyperinflammatory response of the body, as well as with the peculiarities of the patient’s cellular and humoral immunity. Secondary infectious complications in the post-COVID period are due not only to the ability of the SARS-CoV-2 virus to damage erythrocytes and attack the red bone marrow in the acute phase of the disease. It has been proven that the SARS-CoV-2 virus leads to the disappearance of white pulp cells in the spleen, the tissue where cells of the immune response, in particular T- and B-lymphocytes responsible for infectious immunity, mature.
OBJECTIVE. To investigate the frequency of secondary infectious complications of the respiratory tract and lungs in patients with post-COVID syndrome who underwent inpatient treatment.
MATERIALS AND METHODS. Clinical, laboratory and radiological data of 90 patients with post-COVID syndrome who were undergoing inpatient treatment in the clinical departments of the SI “National institute of phthisiology and pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”. The diagnosis of coronavirus disease (COVID-19) was established in accordance with the current national protocol for the treatment. Computed tomography (CT) of the chest organs was performed on the Aquilion TSX-101A scanner (Toshiba, Japan).
RESULTS AND DISCUSSION. Complications of COVID-19 were determined according to the clinical and functional, laboratory examination and CT scan of the chest. Some patients had two or more complications at the same time. Patients with post-COVID syndrome were most often hospitalized for progression or slight positive dynamics of the pathological process of the respiratory tract and lungs, disappearing lung syndrome, fibrotic changes in the lungs, exacerbation of bronchoobstructive lung diseases and infectious complications. The latter were observed most often – in 53,3 % of patients. Fungal and bacterial complications occurred secondarily, mainly in patients with disappearing lung syndrome, in places where cystlike cavities were formed. The most common concomitant diseases in patients with post-COVID syndrome were cardiovascular diseases and diabetes.
CONCLUSIONS. The proportion of infectious complications of the respiratory tract and lungs in patients with post-COVID syndrome, who are indicated for inpatient treatment in the pulmonology department, is 53.3 %. The most frequent causes of infectious complications of the respiratory tract and lungs in patients with post-COVID syndrome are the reactivation of the Epstein – Barr virus infection – in 30.0 %, which in 2.2 % of patients is combined with the reactivation of the hepatitis C virus, and bacterial infections – in 15.6 %. Aspergillosis and mucormycosis occur in 1.1 and 3.3 % of patients respectively.
Specific Primer Design of Leucine Rich Repeats and Guanylate Kinase Domain Containing (LRGUK) Genes in Type II Diabetes Mellitus Patients
Authors: Mushlih Miftahul , Tis’iyyah Siti Nur Maghfiroh , Rini Chylen Setiyo , Sari Azizah Krismonita 
Published: December 2022

Diabetes Mellitus type II (DT2) is a disorder of insulin function (insulin resistance) caused by 2 factors, i.e. environmental and genetic factors. Previous studies have identified the presence of specific alleles that differentiate between DT2 and non-DT2 sufferers. Identification of the allele indicated leucine rich repeats and guanylate kinase domain containing (LRGUK) gene. The aim of this research was to design a specific primer to amplify LRGUK gene. The primer design was based on a 576 bp nucleotide base and added 100 bp in the 5' and 100 bp in the 3' direction using NCBI-Primer BLAST. The primers produced were selected based on eight criteria’s. The results were validated with 6 samples of DT2 patients and visualized using agarose gel. The results of the analysis showed that the primers Forward 5'-TCCTACTCTGTGTCCTTCCTTG-3' and Reverse 5'-GTGGTGACAAGGAGG TTTGC-3' were able to amplify specifically with a length of 687 bp.
Metode Ceramah dan Media Leaflet terhadap Pengetahuan Ibu dalam Pencegahan ISPA
Authors: Sidabutar Sondang Sidabutar , Waruwu Candra Johan 
Published: December 2022

Acute infectious disease (ARI) that attacks one part and or more of the respiratory tract from the nose (upper tract) to the alveoli (lower tract) including adnexa such as sinuses, middle ear cavity and pleura. ARI is a disease that often occurs in children, because the child's immune system is still low. This study aims to determine the effect of health education with the lecture method and leaflet media on increasing maternal knowledge about the prevention of ARI (Acute Respiratory Infection) in the working area of ​​UPT Puskesmas Hiliduho. This type of research is quantitative research with a quasi-experimental research design. The design used was pretest and posttest group design without control group. The location of the research was carried out in the working area of ​​the Hiliduho Health Center, Hiliduho District, Nias Regency. The time of this research was carried out in August 2021. The population in this study amounted to 389 people. The sample in this study was determined by purposive sampling technique. The number of samples is 80 people. The difference in the mean knowledge of mothers before and after the lecture method health counseling was known to have a significant value from the t test for the respondents in the lecture group, namely p = 0.000 (p <0.05). The mean value of the respondent's knowledge before the lecture intervention was 1.98 while the mean value of the respondent's knowledge after the lecture was 1.18. The difference in the mean knowledge of mothers before and after the leaflet media health counseling was p = 0.000 (p <0.05). The mean value of respondents' knowledge before leaflet intervention was 5.68 while the mean value of respondent's knowledge after leaflet was 12.90.

Keywords: lecture method; leaflet media; ARI
IoT based Fire Alerting Smart System
Authors: Al Hasani Ibtehal Mahfoodh Mohammed , Kazmi Syed Imran Ali , Ali Shah Reehan , HASAN RAZA , Hussain Saqib 
Published: December 2022

By combining IoT devices, such as fire alarm systems (smoke and high-temperature sensors), sensors, and other supplementary equipment, the research paper offers the "IOT based Fire Alerting Smart System" in smart buildings. The research article proposes the "IOT based Fire Alerting Smart System" in smart buildings by merging IOT devices such as fire alarm systems (smoke burn with high-temperature sensors), sensors, and other auxiliary equipment. That notification includes the time and location of fire occurs. Comparing two existing smart IoT-based fire warning systems from around the world. The Internet of Things is designed to provide organisations and individuals more visibility, and it now has the ability to govern 99 percent of available surroundings and objects that aren't connected to the Internet. Thus, IOT will be able to accomplish more meaningful work at a higher level by creating opportunities for individuals and businesses so that they can engage more with the outside world more than ever. Old fire alarm systems include many different types of devices that play a particular role in the workings of the system, detecting a person and detecting and wearing out a person through visual and auditory devices in the event of fire, smoke, monoxide carbon or others emergency. These types of alarms can be actuated by manual focus or manual fire alarms, such as suction stations, and can be activated automatically on smoke and heat detectors. The alarm can come with an electric chime. A horn or wall speaker can be a bright tone for a speaker that sounds an alarm; for example, you can add an audio evacuation message to warn you about using the elevator and other warning messages to users.
Co-expression of fibrotic genes in inflammatory bowel disease; A localized event?
Authors: Dovrolis Nikolas , Filidou Eirini , Tarapatzi Gesthimani , Kokkotis Georgios , Spathakis Michail , Kandilogiannakis Leonidas , Drygiannakis Ioannis , Valatas Vassilis , Arvanitidis Konstantinos , Karakasiliotis Ioannis , Vradelis Stergios , Manolopoulos Vangelis G. , Paspaliaris Vasilis , Bamias Giorgos , Kolios George 
Published: December 2022

IntroductionExtracellular matrix turnover, a ubiquitous dynamic biological process, can be diverted to fibrosis. The latter can affect the intestine as a serious complication of Inflammatory Bowel Diseases (IBD) and is resistant to current pharmacological interventions. It embosses the need for out-of-the-box approaches to identify and target molecular mechanisms of fibrosis.Methods and resultsIn this study, a novel mRNA sequencing dataset of 22 pairs of intestinal biopsies from the terminal ileum (TI) and the sigmoid of 7 patients with Crohn’s disease, 6 with ulcerative colitis and 9 control individuals (CI) served as a validation cohort of a core fibrotic transcriptomic signature (FIBSig), This signature, which was identified in publicly available data (839 samples from patients and healthy individuals) of 5 fibrotic disorders affecting different organs (GI tract, lung, skin, liver, kidney), encompasses 241 genes and the functional pathways which derive from their interactome. These genes were used in further bioinformatics co-expression analyses to elucidate the site-specific molecular background of intestinal fibrosis highlighting their involvement, particularly in the terminal ileum. We also confirmed different transcriptomic profiles of the sigmoid and terminal ileum in our validation cohort. Combining the results of these analyses we highlight 21 core hub genes within a larger single co-expression module, highly enriched in the terminal ileum of CD patients. Further pathway analysis revealed known and novel inflammation-regulated, fibrogenic pathways operating in the TI, such as IL-13 signaling and pyroptosis, respectively.DiscussionThese findings provide a rationale for the increased incidence of fibrosis at the terminal ileum of CD patients and highlight operating pathways in intestinal fibrosis for future evaluation with mechanistic and translational studies.
Advanced trauma life support course for medical students. A new era?
Authors: Vassiliu Panteleimon , Mavrogenis Andreas , Theos Christos , Koulouvaris Panagiotis , Massalis Ioannis , Geranios Angelos , Bartsokas Christos , Gerazounis Michael , Tepetes Konstantinos , Kamparoudis Apostolos , Stergiopoulos Spyros , Stavropoulos Michael , Androulakis John 
Published: December 2022

IntroductionTrauma represents a major public health issue and is one of the leading causes of death and disability worldwide. A systematic approach toward dealing with trauma patients was facilitated through the ATLS program, which has become a milestone in trauma care. Our new ATLS course for medical students was set in motion in 2015. Our aim was to make medical students familiar with trauma patients interactively, through a program like ATLS, and here we present the results of this endeavor.MethodsA two-day ATLS-Medical Student (MS) course was offered from November 2015 to July 2018, and analysis was performed retrospectively on the data gathered over a three-month period through online questionnaires. Before graduating, 261 newly qualified medical doctors were interviewed and evaluated as part of the ATLS course.ResultsAfter the course, the vast majority of medical students (251 MSs; 96.16%) felt more capable of managing severely injured patients and 58% of students felt that the medical services they offered were better due to the ATLS training. Regarding the educational fee for the course, 56.7% of the students reported that they felt the fee of 100 euros was fair.DiscussionThe interactive format of the course, which differs from more traditional methods of teaching, has been endorsed by medical students. Though they lack clinical experience, that does not prohibit them from acquiring more specialized or specific knowledge, enabling them to excel. Most of the students improved their skillset either in theoretical knowledge, practical skills, or even in the emotional component of the course, i.e., dealing with treating a severely injured patient. It was decided that the program would be re-evaluated and extended to all Greek Medical Schools.ConclusionThe advantage of providing doctors with trauma training at the beginning of their careers is evident. For that reason, it was decided that the program would be re-evaluated and extended to all Greek Medical Schools.
Resection of supratentorial brain metastases with intraoperative radiotherapy. Is it safe? Analysis and experiences of a single center cohort
Authors: Krauss Philipp , Steininger Kathrin , Motov Stefan , Sommer Bjoern , Bonk Maximilian Niklas , Cortes Abraham , Wolfert Christina , Stueben Georg , Shiban Ehab , Kahl Klaus Henning 
Published: December 2022

IntroductionIntraoperative Radiotherapy (ioRT) is an emerging treatment option in oncologic surgery for various diseases including intraaxial brain lesions to improve surgical outcome and accelerate the adjuvant oncologic therapy. Despite its use in glioma surgery, the application and data regarding ioRT in the treatment of brain metastases (BMs) is sparse. Here were report the largest series of supratentorial BMs treated with resection and ioRT according to functional outcome and adverse events.MethodsWe performed a retrospective chart review analysis of patients undergoing surgery for BMs following an interdisciplinary tumor board decision in every case with ioRT at our institution. Patient properties, functional status (Karnofsky Performance Score/KPS) before and after surgery as well as oncologic (disease, recursive partitioning analysis, lesion size) and operative parameters were analyzed until hospital discharge. Adverse events (AE) were recorded until 30 days after surgery and rated according to the Clavien Dindo Grading (CDG) scale.Results70 patients (40 female) with various oncologic diseases were identified and analyzed. Six underwent prior RT. Mean age was 66 ± 11 years. Preoperative median KPS was 80% with a mean BM volume of 3.2 ± 1.2 cm3. Nine patients (13%) experienced in total 14 AEs, including 2 cases (3%) of postoperative death (CDG5) and 2 with new postoperative epilepsy necessitating additional pharmacotreatment (CDG2). Five patients suffered from new neurologic deficit (CDG1) not needing further surgical or medical treatment. After surgery, the neurological status in 7 patients (10%) deteriorated while it improved in 21 cases (30%). Patients experiencing AEs had longer hospitalization and poorer postoperative KPS mdn. 90 vs. 80%. There was no statistically significant deterioration of the functional status during the immediate postoperative course in the whole patient cohort.ConclusionSurgery for supratentorial BMs with ioRT seems safe and feasible. Further studies on the benefit regarding oncologic outcome need to be performed.
Oblique lateral interbody fusion in heterogenous lumbar diseases: Anterolateral screw fixation vs. posterior percutaneous pedicle screw fixation – A single center experience
Authors: Wu Meng-Ting , Chung Tzu-Tsao , Chen Shao-Ching , Kao Tzu-Jen , Song Wen-Shin 
Published: December 2022

BackgroundOblique lateral interbody fusion (OLIF) is a type of minimally invasive lateral lumbar interbody fusion technique used for treating lumbar degenerative diseases. This study aimed to analyze the clinical and radiographic efficacy of OLIF with anterolateral screw fixation alone and OLIF requiring fixation with conventional posterior percutaneous pedicle screws for lumbar diseases.MethodsMedical records of consecutive patients admitted to Cheng-Hsin Hospital who received OLIF between January 2019 and December 2020 were retrospectively reviewed. Patients were divided into two groups by screw fixation: patients who received anterolateral screw fixation alone were defined as one-stage OLIF (n = 9) and patients who received fixation with conventional posterior percutaneous pedicle screw were defined as two-stage OLIF (n = 16). Patient clinical characteristics, medical history, intraoperative blood loss, length of hospital stay, peri-operative, and post-operative complications were evaluated in all patients.ResultsDuring the study period, a total of 25 patients were successfully treated with OLIF (n = 9 one-stage; n = 16 two-stage). Two-stage OLIF was associated with longer operation times, longer hospital stays, shorter bed-rest time, and a greater likelihood of having a blood transfusion compared with the one-stage OLIF group. A higher proportion of grade I subsidence was observed at 6 months and 1 year after surgery in the two-stage group compared with the one-stage group. Post-operative complications included ileus, dystonia, and dystonia were higher in the two-stage OLIF group. Improvements in radiographic parameters were demonstrated after OLIF, and the improvements were comparable between one-stage and two-stage OLIF.ConclusionsOne-stage OLIF is a feasible and efficacious treatment method for single- and multiple-level degenerative lumbar diseases. Additional clinical follow-up is necessary to confirm long-term outcomes.
FAKTOR-FAKTOR YANG MEMPENGARUHI KETERLAMBATAN BICARA DAN BAHASA PADA ANAK BALITA: STUDI LITERATUR
Authors: Pratiwi Merita Meliyafara , Yanuarini Triatmi Andri , Yani Erna Rahma 
Published: December 2022

ABSTRAK
Keterlambatan bicara dan bahasa merupakan permasalahan perkembangan yang dapat terjadi pada anak balita. Keterlambatan bicara dan bahasa dapat dipengaruhi oleh beberapa faktor baik dari faktor anak atau faktor orang tua. Tujuan studi literatur ini untuk mendapatkan gambaran faktor-faktor yang mempengaruhi keterlambatan bicara dan bahasa pada anak balita. Penelitian studi literatur ini menggunakan desain studi systematic mapping study dengan sumber literatur yang didapatkan dari database Pubmed, Wiley, Science Direct, Proquest, SINTA dan Google Scholar. Strategi pengumpulan literatur menggunakan PEOS selanjutnya diseleksi sehingga menghasilkan 27 artikel yang sesuai dengan kriteria penelitian menggunakan tahun publikasi 2017-2021. Berdasarkan 27 artikel yang dianalisis menghasilkan faktor jenis kelamin dapat mempengaruhi keterlambatan bicara dan bahasa pada anak balita yaitu jenis kelamin laki-laki, riwayat prenatal dan perinatal yang mempengaruhi yaitu kelahiran premature dan berat badan lahir rendah, penerapan pola asuh yang dapat mempengaruhi yaitu penerapan asuh yang kurang tepat, durasi penggunaan gadget yang mempengaruhi yaitu lebih dari 30 menit/hari, dan pemberian stimulasi yang dapat mempengaruhi yaitu kurangnya ketepatan pemberian stimulasi.
Terdapat hubungan antara faktor jenis kelamin, riwayat prenatal dan perinatal, penerapan pola asuh, durasi penggunaan gadget, pemberian stimulasi dengan keterlambatan bicara dan bahasa. Pentingnya melakukan pemantauan saat kehamilan, melakukan persiapan menjadi calon orang tua, dan melakukan deteksi dini tumbuh kembang setelah anak lahir.