bluuebunny/crossref_metadata_2025_split huggingface dataset:
Opportunistic PSA-free prostate cancer screening utilising biparametric MRI (VISIONING)
Authors: Wetterauer C. , Matthias M. , Pueschel H. , Deckart A. , Bubendorf L. , Mortezavi A. , Arbelaez E. , Winkel D.J. , Heye T. , Boll D.T. , Merkle E. , Hayoz S. , Seifert H.H. , Rentsch C.A. 
Published: September 2023

AbstractBackgroundLiterature suggests that prostate MRI exhibits better predictive capabilities compared to prostate-specific antigen (PSA) in detecting prostate cancer (PCa). Based on this, our present study investigates biparametric MRI (bpMRI) as a PSA-independent screening tool for PCa.ObjectiveThe primary endpoint was to assess the efforts and effectiveness of identifying 20 participants with clinically significant prostate cancer (csPCa) using bpMRI.Design, Setting, and ParticipantsBiopsy-naïve men aged over 45 years were included. All participants underwent 3 Tesla bpMRI, PSA and digital rectal examination (DRE). Targeted-only biopsy was performed in participants with a suspicious lesion (PI-RADS≥3). Men with a negative bpMRI but suspicious DRE or elevated PSA had template biopsies. Pre-intended protocol adjustments were made post-interim analysis for PI-RADS 3 lesions: follow-up mpMRI after 6 months, biopsy only if lesions persisted or upgraded.Outcome Measurements and Statistical AnalysisBiopsy results underwent comparison using Fisher’s exact test and univariable logistic regression to pinpoint prognostic factors for positive biopsy.Results and LimitationsA total of 229 participants were enrolled in this analysis. Among these, 77 displayed suspicious PI-RADS lesions. A total of 79 participants underwent a biopsy. PCa was detected in 29 participants, of whom 21 had csPCa.BpMRI detected all 21 csPCa, whereas PSA and DRE missed 66.7%. Protocol adjustment led to a 54.6 % biopsy reduction in PI-RADS 3 lesions. Overall, 10.9 bpMRIs were needed to identify one participant with csPCa. A major limitation of the study is the lack of a control cohort undergoing template biopsies.ConclusionsOpportunistic screening utilising bpMRI as primary tool reveals participants with csPCa that traditional methods might overlook, even at low PSA levels.Patient summaryScreening with bpMRI and targeted biopsy identified csPCa in every 11thman, regardless of PSA levels. Preselecting patients based on PSA > 1 ng/ml and positive family history of PCa as well as other potential blood tests may further improve the effectiveness of bpMRI in this setting.
Comparison of Different PCR Methods for the Detection of SARS-CoV-2 RNA in Wastewater Based on the Reported Incidence of COVID-19 in Finland
Authors: Länsivaara Annika , Lehto Kirsi-Maarit , Hyder Rafiqul , Janhonen Erja , Lipponen Anssi , Heikinheimo Annamari , Pitkänen Tarja , Oikarinen Sami ,   the WastPan Study Group
Published: September 2023

AbstractThe spatial and temporal changes of the COVID-19 pandemic have been monitored with wastewater-based surveillance, which many countries have applied to their national public health monitoring measures. The most commonly used methods for the detection of SARS-CoV-2 in wastewater are RT-qPCR and RT-ddPCR. Previous comparisons of the two methods have produced conflicting results; some found RT-ddPCR to be more sensitive, one found RT-qPCR to be more sensitive, and others found them to be equal in sensitivity. This research was conducted to further study these two methods as well as two different RNA extraction methodologies and gene assays for the detection of SARS-CoV-2 in wastewater. We compared two RT-qPCR kits and RT-ddPCR based on sensitivity, variability, and the correlation of SARS-CoV-2 gene copy numbers in wastewater with the incidence of COVID-19. Our results indicate that the most sensitive and low-variance method to detect SARS-CoV-2 in wastewater was RT-ddPCR. However, we obtained the best correlation between COVID-19 incidence and SARS-CoV-2 gene copy number in wastewater using RT-qPCR (CC = 0.697, p < 0.001). We found a significant difference in sensitivity between the two RT-qPCR kits, one having a significantly lower limit of detection and a higher percentage of positive samples than the other. Furthermore, the CDC N1 primers and probe were the most sensitive for both RT-qPCR kits, while there was no significant difference between the tested gene targets using RT-ddPCR. For the most sensitive RT-qPCR, the use of different RNA extraction kits affected the result. All methods showed a trend between COVID-19 incidence and SARS-CoV-2 gene copy numbers in wastewater. In addition, we tested an isothermal amplification method for the detection of SARS-CoV-2 RNA in wastewater. It proved to be a viable option if results are expected quickly, resources are limited, and presence–absence information is sufficient.HighlightsUsing different RNA extraction kits, detection kits, and gene assays to detect SARS-CoV-2 in wastewater produces differing results.SARS-CoV-2 gene copies in wastewater correlate with the reported incidence of COVID-19 in Finland.RT-ddPCR was the most sensitive and repeatable method to detect SARS-CoV-2 in wastewater, whereas RT-qPCR had the best correlation to the incidence of COVID-19.RT-SIBA is a viable option for the detection of SARS-CoV-2 in wastewater in low-resource settings.All methods have high result variability when the amount of SARS-CoV-2 in wastewater is low.Graphical abstractCreated withBioRender.com
Extracellular Matrix Abnormalities in the Hippocampus of Subjects with Substance Use Disorder
Authors: Valeri Jake , Stiplosek Charlotte , O’Donovan Sinead M. , Sinclair David , Grant Kathleen , Bollavarapu Ratna , Platt Donna M. , Stockmeier Craig A. , Gisabella Barbara , Pantazopoulos Harry 
Published: September 2023

ABSTRACTContextual triggers are significant factors contributing to relapse in substance use disorders (SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as mediators of reward memories. Chondroitin sulfate proteoglycans (CSPGs) are a subset of ECM molecules that form perineuronal nets (PNN) around inhibitory neurons. PNNs restrict synaptic connections and help maintain synapses. Rodent models suggest that modulation of PNNs may strengthen contextual reward memories in SUD. However, there is currently a lack of information regarding PNNs in the hippocampus of people with SUD as well as how comorbidity with major depressive disorder (MDD) may affect PNNs. We used postmortem hippocampal tissues from cohorts of human and nonhuman primates with or without chronic alcohol use to test the hypothesis that PNNs are increased in subjects with SUD. We used histochemical labeling and quantitative microscopy to examine PNNs, and qRT-PCR to examine gene expression for ECM molecules, synaptic markers and related markers. We identified increased densities of PNNs and CSPG-labeled glial cells in SUD, coinciding with decreased expression of the ECM protease matrix metalloproteinase 9 (Mmp9), and increased expression for the excitatory synaptic marker vesicle associated membrane protein 2 (Vamp2). Similar increases in PNNs were observed in monkeys with chronic alcohol self-administration. Subjects with MDD displayed changes opposite to SUD, and subjects with SUD and comorbid MDD had minimal changes in any of the outcome measures examined. Our findings demonstrate that PNNs are increased in SUD, possibly contributing to stabilizing contextual reward memories as suggested by preclinical studies. Our results also point to a previously unsuspected role for CSPG expression in glial cells in SUD. Evidence for increased hippocampal PNNs in SUD suggests that targeting PNNs to weaken contextual reward memories is a promising therapeutic approach for SUD, however comorbidity with MDD is a significant consideration.
Flexible adaptation of task-positive brain networks predicts efficiency of evidence accumulation
Authors: Weigard Alexander , Angstadt Mike , Taxali Aman , Heathcote Andrew , Heitzeg Mary M. , Sripada Chandra 
Published: September 2023

AbstractEfficiency of evidence accumulation (EEA), an individual’s ability to selectively gather goal-relevant information to make adaptive choices, is thought to be a key neurocomputational mechanism associated with cognitive functioning and transdiagnostic risk for psychopathology. However, the neural basis of individual differences in EEA is poorly understood, especially regarding the role of largescale brain network dynamics. We leverage data from over 5,000 participants from the Human Connectome Project and Adolescent Brain Cognitive Development Study to demonstrate a strong association between EEA and flexible adaptation to cognitive demand in “task-positive” frontoparietal and dorsal attention networks, which explains 36%-39% of the variance across individuals in EEA. Notably, individuals with higher EEA displayed divergent task-positive network activation across n-back task conditions: higher activation under high cognitive demand (2-back) and lower activation under low demand (0-back). These findings suggest that brain networks’ flexible adaptation to cognitive demands is a key neural underpinning of EEA.
Development of Sensorimotor-Visual Connectome Gradient at Birth Predicts Cognitive Outcomes at 2 Years of Age
Authors: Xia Yunman , Xu Yuehua , Duan Dingna , Xia Mingrui , Jeon Tina , Ouyang Minhui , Chalak Lina , Rollins Nancy , Huang Hao , He Yong 
Published: September 2023

AbstractFunctional connectome gradients represent fundamental brain organizing principles. Here, we investigate the maturation of the macroscopic connectome gradients in a task-free functional MRI dataset consisting of 39 preterm and term babies aged 31-42 postmenstrual weeks and its connection with postnatal cognitive growth. We show that the principal sensorimotor-to-visual gradient is present in baby connectomes around 35.6 postmenstrual weeks and continuously develops towards a more term-like pattern. The gradient’s global topographical structure undergoes progressive maturation with age, characterized by increases in explanation ratio, gradient range and gradient variation. The development of focal gradients is mostly localized in primary regions serving sensory, motor and visual functions. Machine learning approaches revealed that the connectome gradient at birth significantly predicts individual cognitive outcomes at 2-y follow-up. These findings highlight the early emerging rules of functional connectome gradients and have implications for understanding how the connectome gradients at birth underlies cognitive growth in later life.HighlightsSensorimotor-to-visual gradient is present around 35.6 postmenstrual weeksGlobal gradient structure undergoes substantial changes during the third trimesterRegional gradient develops mostly in primary sensory, motor, and visual regionsSensorimotor-to-visual gradient at birth predicts cognitive outcomes at age 2
Risk and Protective Factors for Self-Harm and Suicide Behaviours among Serving and Ex-Serving Personnel of the UK Armed Forces, Canadian Armed Forces, Australian Defence Force and New Zealand Defence Force: A Systematic Review
Authors: Williamson Charlotte , Croak Bethany , Simms Amos , Fear Nicola T. , Sharp Marie-Louise , Stevelink Sharon A.M. 
Published: September 2023

ABSTRACTPurposeSelf-harm and suicide behaviours are a major public health concern. Several factors are associated with these behaviours among military communities. Identifying these factors may have important implications for policy and clinical services. The aim of this review was to identify the risk and protective factors associated with self-harm and suicide behaviours among serving and ex-serving personnel of the United Kingdom Armed Forces, Canadian Armed Forces, Australian Defence Force and New Zealand Defence Force.MethodsA systematic search of seven online databases (PubMed, Web of Science, Embase, Global Health, PsycINFO, PTSDpubs and CINAHL) was conducted alongside cross-referencing, in October 2022. Following ana prioriPROSPERO approved protocol (CRD42022348867), papers were independently screened and assessed for quality. Data were synthesised using a narrative approach.ResultsOverall, 28 papers were included: 13 from Canada, 10 from the United Kingdom, five from Australia and none from New Zealand. Identified risk factors included being single/ex-relationship, early service leavers, shorter length of service, junior ranks, exposure to deployment-related traumatic events, physical and mental health diagnoses, and experience of childhood adversity. Protective included being married/in a relationship, higher educational attainment, employment, senior ranks, and higher levels of perceived social support.ConclusionAdequate care and support are a necessity for the military community. Prevention and intervention strategies for self-harm and suicide behaviours should be introduced early and should promote social networks as a key source of support. This review found a paucity of peer-reviewed research within some populations. More peer-reviewed research is needed, particularly among these populations where current work is limited, and regarding modifiable risk and protective factors.
Fair value estimates of investment property, corporate governance and audit pricing: evidence from the Hong Kong real estate industry
Authors: Tang Feng 
Published: September 2023

PurposeFollowing the adoption of International Financial Reporting Standards (IFRS), firms are required to recognize gains or losses from investment property revaluation in the income statement, instead of equity in the balance sheet. This results in both a “materiality effect” (as auditors set a higher materiality level and require lower audit efforts) and a “cushion effect” (as revaluation gains serve as a cushion and reduce earnings manipulation incentives). Utilizing this unique setting, this study investigates whether the use of fair value measurement for investment property affects audit pricing before and after IFRS convergence in the Hong Kong real estate industry.Design/methodology/approachUsing a sample of 78 real estate companies listed on the Hong Kong Stock Exchange in the pre-IFRS period (2001–2004) and the post-IFRS period (2005–2008), this study employs multivariate regression analyses to test the research hypotheses with respect to the association between investment property revaluation and audit fees and the role of corporate governance structures in the context of family control.FindingsThe empirical results suggest that audit fees decrease with revaluation gains or losses from investment property revaluation after IFRS convergence, but not before. Furthermore, the negative association is stronger in companies controlled by founders, with proportionally more independent directors on the board and with a smaller board size. This is consistent with the moderating effect of corporate governance.Originality/valueThe findings shed more light on the consequences of fair value accounting for non-financial assets and are of interest to regulators for assessing the benefits of the wide use of fair value measurement under IFRS in emerging markets, especially where the corporate ownership structure is typically controlled by founding families. This study also provides recommendations for the audit community to fully consider the impact of asset revaluation on audit procedures and audit pricing.
Constraints and stimuli in the implementation of public accounting reform: systematic literature review and future research agenda
Authors: Liberato Margarida Isabel , Choban de Sousa Paiva Inna , Serrasqueiro Rogério 
Published: September 2023

Purpose
The purpose of this study is to discuss the most relevant literature related to the adoption of International Public Sector Accounting Standards (IPSAS) in the public sector in developed and developing countries, identifying the constraints and stimuli they represent in the implementation of the public accounting reform. It also presents future research proposals on the factors identified.

Design/methodology/approach
The methodology is based on a systematic review of the literature described by Moher et al. (2009). The final sample includes 90 academic papers published from 2000 to 2022.

Findings
The main findings indicate that there are differences between constraints and stimuli in the implementation of accounting standards between developed and developing countries. In terms of constraints, the main factor in developed countries is the lack of training, whereas in developing countries it is the limitation on financial resources. In addition, the results demonstrate that in developed countries the factors that most encourage the implementation of accounting standards are modernization and improvement of accounting, while in developing countries, encouragement comes mainly from external and internal pressure.

Practical implications
This study helps countries and institutions to learn from experience and better prepare for the accounting reforms of public administration that they will undertake. Managers of public organizations may be willing to make decisions in the adoption of IPSAS if they take into account the factors established herein.

Social implications
This study helps countries and institutions to learn from the experience, better prepare for the public administration accounting reforms that they will undertake and add greater transparency in the accountability of public accounts to citizens.

Originality/value
In addition to previous studies, this study addresses a number of factors perceived by those involved in the implementation of IPSAS in developed and developing countries and provides a robust research agenda to pursue during the coming years, as there are several important unexplored questions that invite further research.
City brand love: destination attractiveness and memorable tourism city experiences
Authors: Ghorbanzadeh Davood 
Published: September 2023

Purpose
Drawing on the literature on brand–consumer relations in an attempt to apply the concept of brand love to a city tourism destination, this paper aims to explore the antecedents and consequences of city brand love.

Design/methodology/approach
Based on quantitative research and cluster sampling, study data was collected from 330 international tourists who visited six Iran cities. The research model is tested using partial least square structural equation modeling.

Findings
According to the results, city brand attractiveness, city brand identification and memorable city brand experience are the antecedents of city brand love. Moreover, the city brand attractiveness, both directly and indirectly through memorable experiences and identification with the city brand, is one of the antecedents of city brand love. Finally, the results suggest that word of mouth and revisit intention are major behavioral outcomes of city brand love.

Originality/value
By providing a validated conceptual model that traces the antecedents and consequences of city brand love, this study attempts to answer prior calls for examination from the viewpoint of city tourism scholars.
Taxonomic and phylogenetic perspectives reveal the community assembly of different forest strata along an altitudinal gradient
Authors: Wan Jiamin , Chen Yang , Li Yanpeng , Zhang Caicai , Huang Zhipang , Xiao Wen 
Published: September 2023

AbstractDisentangling the distribution patterns of biodiversity along altitudinal gradients and their drivers has been a hot topic in ecological research. Different forest strata show multiple distribution patterns influenced by different community assembly mechanisms. Here, we measure the dominant ecological processes affecting three forest strata (tree, shrub, and herb layers) along altitudinal gradients. We sampled plants with different forest strata in 21 plots located from 2500 to 3700 m in Lasha Mountain, northwestern Yunnan. The taxonomic alpha diversity of the herb layer showed a monotonic decreasing trend with increasing altitude, while the shrub layer was characterized by a single peak, and the tree layer showed no significant change with increasing altitude. We observed a decreasing pattern of phylogenetic diversity with increasing altitude in the herb layer, whereas phylogenetic diversity did not change in the tree and shrub layers. The phylogenetic structure of these three layers showed the same pattern: phylogenetic clustering at low altitudes and overdispersion at middle and high altitudes. The diversity and phylogenetic structure of the herb layer were driven by climate (average dry season precipitation) and topographic (slope and aspect) factors, while shrub layer diversity was mainly influenced by tree layer richness. Overall, the phylogenetic structure pattern of the three forest strata changed from clustered to overdispersed with increasing altitude, indicating that environmental filtering was the main driver at low altitudes, while interspecific competition dominated at middle and high altitudes.
A field‐based study demonstrating the need of holistic management system for household biogas plants in rural India
Authors: Sarmah Trinakshee , Baruah Debendra Chandra 
Published: September 2023

AbstractIndian household biogas system appears promising to contribute substantially to its commitment to increase the share of renewable energy. There has been a consistent effort to promote the household biogas system by the Government of India. Despite such need and effort, the growth of household biogas system in India is not encouraging. Further, the need for appropriate management services for hassle‐free operation and maintenance of household biogas system is also analyzed based on field survey conducted in three villages. Cow dung is the primary feedstock and its abundant availability results in a higher level of adoption of household biogas plants in one of the villages. Alternative feedstocks can adequately supplement cow dung to support the household biogas system in the remaining two villages. Though the higher capital cost of the biogas system is a distracting factor, biogas as a cooking fuel is cheaper than both LPG and fuelwood while considering long‐term analysis. Thus, the continuation of subsidy on household biogas plant is justified considering the issue of affordability to bear capital cost even though for long‐term use non‐subsidized option is also profitable. The non‐availability of own feedstock is a critical issue which influences the economy of biogas users and hence the motivation. Analysis also revealed that the undesirable performance of household biogas system is mostly linked with the absence of proper diagnosis. Chronical poor performance is attributed to one or more factors related to feedstock, microbial activities, and climatic parameters which remain unknown to the users and lead to their diminishing interest. Technology‐integrated management support is expected to revive the interest in household biogas system in rural India.