bluuebunny/crossref_metadata_2025_split huggingface dataset:
O EFEITO DEVASTADOR DA PANDEMIA PARA AS MULHERES E A INFLUÊNCIA NAS CONDIÇÕES DE VIDA E TRABALHO
Authors: Lessa Cardoso Adriana , Ávila Chiarelli Lígia Maria 
Published: May 2023

O presente artigo busca compreender importantes consequências da pandemia sobre a vida e o trabalho das mulheres, sugerindo apontamentos que se identifiquem com as necessidades de mudança social e com as novas questões que devem ser tratadas pelos movimentos sociais e na academia, no que diz respeito às políticas públicas direcionadas ao trabalho das mulheres. O referencial teórico utilizado para reflexão e análise tem como princípio o paradigma feminista crítico-dialético da divisão sexual do trabalho, visando à eliminação das hierarquias e acúmulo de tarefas. Utilizou-se revisão bibliográfica e documental como metodologia. Assim, conclui-se que a pandemia tem um efeito devastador para a vida da população em geral, mas as mulheres, em que se considere o recorte de raça e classe, ainda são as mais prejudicadas devido à cultura patriarcal e sexista fundamentadora do capitalismo. Neste sentido, aponta-se para a necessidade de atualizar, definir novas pautas e fomentar o protagonismo das mulheres na transformação social.
Ectopic Cushing’s syndrome: clinical, diagnostic, treatment and follow-up outcomes of 12 cases of lung ectopic ACTH
Authors: González Fernández Laura , Maricel Rivas Montenegro Alejandra , Brox Torrecilla Noemí , Miguélez González María , Atencia Goñi Jose , Fernández Fernández Elisa , González Albarrán Olga , Carlos Pércovich Hualpa Juan , Sambo Salas Marcel , García Centeno Rogelio 
Published: May 2023

Summary
Ectopic Cushing’s syndrome (ECS) is a rare disease associated with significant comorbidity. Among the causes of Cushing's syndrome, adrenocorticotropic hormone-producing extrapituitary tumours are rarely reported. This low frequency makes it difficult for the physician to acquire experience in its management.
In this report, we aimed to describe the clinical presentation, diagnostic approach and treatment modalities of 12 patients with ECS treated in a single tertiarycentre over a 17-year period. Although they can appear in different locations through the neuroendocrine system, lung tumours are the most frequently reported, as it occurs in our series. They can show different levels of aggressiveness and mild to severe clinical course. Therefore, distinguishing Cushing's disease can be challenging and sometimes requires more specific techniques such as invasive tests or no conventional imaging. Treatment includes controlling both hypercortisolism and neoplastic disease, and multidisciplinary management is recommended.

Learning points

Ectopic Cushing's syndrome (ECS) accounts for 15% of endogenous Cushing's syndromes. Its infrequency implies that both diagnosis and treatment can be a challenge for clinicians without experience in its management.

The most common location is the lung. Although older series reported small cell lung carcinoma (SCLC) as the main ECS-producing tumour, currently most cases are attributed to lung carcinoids.

Low-grade tumours (lung carcinoids) present themselves with a more subtle and gradual hypercortisolism, and clinically this can be difficult to differentiate from hypercortisolism due to CD. In contrast, high-grade tumours (SCLC) show severe hypercortisolism with rapid evolution.

The diagnostic approach is complex especially when the tumour is not previously known and the clinical presentation is subtle. Functional tests are mandatory in these cases, and nuclear medicine imaging can help when conventional imaging tests fail to identify the tumour.

ECS treatment includes a wide variety of modalities oriented to treat both the excess of cortisol and the tumour itself. The tumour prognosis depends fundamentally on the type of adrenocorticotropic hormone-secreting tumour.

Expert and multidisciplinary team is essential for successfully treating these complex and ill patients.
The Development of Derivative Method analysis 1,4 Benzodiazepines in Biological Matrix using High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass
Authors: Putri Annisa Larasati , Supandi Supandi , Mansur Umar 
Published: May 2023

1.4 benzodiazepine derivatives are the benzodiazepine class that is used most frequently in clinical as a sedation agent, anxiolytic, and antiepileptic. The high tense of benzodiazepine consumption can causes addiction and misappropriation. That matter causes benzodiazepine and its metabolites often find in toxicology clinical and forensic. This systematic review aimed to identify an efficient sample preparation procedure and an accurate analysis method to determine benzodiazepine existence in various biological matrices. According to the PRISMA flow diagram’s chart, twenty-four reviewed articles systematically pointed that plasma and urine utilization gave good accuracy results and recovery than other biological matrices. SBSE extraction method development using vinylpyrrolidone ethylene glycol dimethacrylate polymer gave efficient results with the amount of recovery 96%, and HPLC instrument utilization was still selective and sensitive with LOD until 12ng/ml and LOQ 36 ng/ml.
Dental Age Estimation by Assessing the Pulp Volume of Five Teeth in a Peruvian Population Using Cone Beam Computed Tomography Images
Authors: Salvatierra Gálvez Juliana Magaly , Díaz-Suyo Antonio , Alvarado Muñoz Erika Ruth , Kapoor Priyanka , Chowdhry Aman , Velezmoro Montes Ymelda Wendy , Rivas Quispe Aldren Godofredo 
Published: May 2023

Dental age estimation is very important for individual identification in criminal and civil forensic investigations. One of the methods for age estimation is studying age related changes in pulp volume of teeth. The objective of the current study was to estimate dental age from the pulp volume of five different categories of teeth of a Peruvian sample using cone beam computed tomography (CBCT). Retrospective CBCT records of 231 patients [females (134), males (97), age: 12-60 years] were included in the study, categorized into five different age groups (12-19, 20-29, 30-39, 40-49, 50-59, 60 years and older). Dental pulp volume of five categories of teeth(upper canines, left upper central incisors, left upper first molars, lower left first premolars, first molars) were analyzed using Romexis® 5.3.3.5 software for each patient. There was a reduction in the pulp volume of upper right and left canine with age. The pulp volume was lowest in people aged 60 years and over. Linear regression analysis of the pulp volume and chronological age showed a coefficient of determination of 30%, suggesting a weak correlation. A weak correlation between dental pulp and age is derived. But, a robust large homogenous sample of teeth in future for different age groups may establish a reliable regression equation.
Towards reef restoration in Zihuatanejo, Guerrero, México: lessons learned
Authors: Nava Héctor , González-Rodríguez Antonio , Narchi Nemer E. , Méndez-Medina Ana Crisol , Maldonado-López Yurixhi , Cárdenas-Alvarado María Angeles , Figueroa-Camacho Antonieta Gina , Drouet-Cruz Huran Tonalli , Corona-Morales Néstor 
Published: May 2023

Introduction: Coral reef structures in Zihuatanejo, Guerrero are well-preserved. The coverage of living corals, near 60 % at several locations, makes them comparable to other coral reefs in the states of Oaxaca, Jalisco, and Nayarit and with high potential to promote their conservation.
Objective: To present the outcome of 12 years of research in coral communities from Zihuatanejo, Guerrero, as a justifying argument for the current conservation efforts in the area.
Methods: We developed a baseline on the conservation status of the reef structures, bioerosion processes and the source of major natural and anthropogenic impacts. We assessed the genetic diversity of the coral zooxanthellae symbionts, the outcome of a technique of coral transplantation to recover the coverage of living corals and the local ecological knowledge to involve local inhabitants to promote conservation.
Results: At least five coral reefs remain exposed to a medium-low level of impact by bioerosion and anthropization. Coral transplantation experiments made in the area showed records of transplant survival nearing 90 %. Although the warming of the sea surface temperature that occurred during the El Niño of 2015-2016 caused coral bleaching and mortality in several coral populations in this area, there were no affectations attributed to this phenomenon in other locations. This response was not related to the level of exposure to anthropogenic impacts, and the presence of thermal resistant zooxanthellae was assessed using molecular tools, confirming the existence of zooxanthellae of the genus Durusdinium. The analysis of local ecological knowledge of the inhabitants of Zihuatanejo showed that they keep elaborate knowledge on the ecology of coral reefs. This is complemented with scientific knowledge that will encourage community participation in conservation strategies.
Conclusions: A long-term multidisciplinary strategy is required for coral reef conservation that encompasses: 1) assessing the role of the overall holobiont in the thermal resistance of corals from this area and 2) establishing restoration strategies of coral reefs that include the local knowledge about marine ecology, for the establishment of coral reef protection and management schemes put in place by local inhabitants.
The contribution of assisted coral restoration to calcium carbonate production in Eastern Pacific reefs
Authors: Tortolero-Langarica J. J. Adolfo , Rodríguez-Troncoso Alma P. , Alvarez-Filip Lorenzo , Cupul-Magaña Amílcar L. , Carricart-Ganivet Juan P. 
Published: May 2023

Introduction: Hermatypic corals have the capacity to construct the physical reef-framework and maintain the balance of coral reef functionality. However, in the past three decades, coral communities have been menaced by natural and anthropic pressures, resulting in an abrupt coral cover decline, and slow natural recovery. To mitigate coral reef collapse, assisted restoration techniques has been implemented and improved worldwide, However, the long-term effects of such interventions on ecological attributes have been scarcely reported.
Objective: This study evaluated the effect of assisted coral intervention on calcium carbonate production (kg CaCO3 m-2 yr-1) and ecological volume (cm3) yielded by branching and massive corals from the central Mexican Pacific.
Methods: We used colony size, extension rate, and skeletal density measurements of direct outplanted Pocillopora and Pavona coral species to calculate coral carbonate production, ecological volume, and model their long-term potential.
Results: Coral carbonate produced after one-year of outplanting increased by 42 % (1.17 kg CaCO3 m-2 yr-1), where Pocillopora spp. and Pavona clavus corals contribute with 0.97 and 0.20 kg CaCO3 m-2 yr-1, respectively. The ecological volume also increased by 384 cm3 for Pocillopora and 56 cm3 for Pavona after one year period. Furthermore, the results suggest that long-term coral restoration actions (10 years) have the potential to significantly increase carbonate production.
Conclusions: our data indicate that coral restoration initiatives have the potential to help mitigate the current low calcium carbonate production of Mexican Pacific reefs and may significantly contribute to the long-term maintenance of reef-framework based on ecological engineering tools, such initiatives represent essential functional properties related to reef ecosystem services provision.
Settlement and post-settlement survival of Orbicella annularis and Orbicella faveolata (Scleractinia: Merulinidae) on substrates with coatings
Authors: Arango-Carvajal Laura C. , Quan-Young Lizette I. , Villegas-Jiménez Adrián , Banaszak Anastazia T. 
Published: May 2023

Introduction: One of the main bottlenecks in restoration projects based on sexual reproduction is post-settlement survival, mainly due to competition for substrate with fleshy algae and predation. Therefore, substrates of different shapes and materials have been created and tested, seeking to optimize these processes with attractive surfaces for the larvae and structures where the recruits are protected from predation, and competition is reduced.
Objective: To improve settlement and post-settlement survival of two important Caribbean reef-building corals, using different coatings on substrates.
Methods: To determine whether substrate coatings properties are favourable to larval settlement in Orbicella annularis, and O. faveolata, collected in Puerto Morelos, Mexican Caribbean, we evaluated their settlement for three weeks on six coatings with a combination of properties. Each coating was designed to provide a combination of two out of three properties: 1) water repellence (hydrophobicity), 2) phosphorescence-based colour, and 3) mineral-enriched surface chemistry. In a separate experiment larvae settlement was tested using coatings with a single property. Finally, we determined the post-settlement survival of O. annularis and O. faveolata on the different coatings for seven weeks.
Results: The combination of high hydrophobicity and light blue phosphorescent microparticles and high hydrophobicity and red-orange phosphorescent microparticles resulted in a higher settlement of O. annularis and O. faveolata when compared with other coatings (30.8 - 66.7 % higher). No significant differences were found in the number of larval settled when the water-repellence and the phosphorescence-based were evaluated independently. Post-settlement survival time on substrates was low, with a maximum of 34 days after settlement for O. annularis and 42 days for O. faveolata.
Conclusions: In terms of the larval settlement, the combination of the coatings properties appears to play an essential role in the choice of microhabitat for both O. annularis and O. faveolata. But individually these properties did not generate an advantage in the larval settlement. Moreover, some chemical components associated with the coatings may be counterproductive to the survival of the polyps over time.
Succession of the sessile benthic community at a coral reef restoration site.
Authors: Chomitz Benjamin R. , Kleypas Joan Anne , Cortés Jorge , Alvarado Juan José 
Published: May 2023

Introduction: Ecosystem restoration facilitates ecological succession. When a coral reef experiences a disturbance, the community of sessile benthic organisms can follow a successional trajectory that favors the dominance of coral or a change of state to an ecosystem dominated by algae.
Objective: To better understand the impact of coral transplants on succession of the sessile benthic community, this study
Methods: To measure and monitor the coral cover (cm2) of Pocillopora spp., and the composition of the associated benthic community, experimental and control coral reef patches were established at the coral restoration site in Golfo Dulce, South Pacific Costa Rica. Thirty Pocillopora spp. colonies were attached to nails on the substrate in an experimental patch. The control coral patch contained nails with non-transplanted colonies. Both treatments were photographed monthly during a period of eight months. Changes in the coverage of coral and other sessile benthic organisms were measured from the images and compared over time between the experimental and control patches.
Results: The coral transplants experienced bleaching events in August through September 2019 and January through February 2020. The first bleaching event possibly due to sedimentation, and the second to high temperatures. By the end of the experiment, 83 % of the colonies had survived. The live colonies grew significantly following transplantation; > 67 % of their initial coverage area after eight months. In the experimental patch, the areas of Pocillopora spp., coralline crustose algae (CCA), and cyanobacteria increased while the area of algal turf decreased. The increase in coral coverage and CCA, and decrease in algal turf in the experimental patch could be due to herbivores attracted to transplants. The increase in cyanobacteria in the experimental patch could be the result of higher temperatures and may have been a factor in the death of colonies.
Conclusions: The transplantation of Pocillopora spp. colonies in Golfo Dulce changed the early successional trajectory of the sessile benthic community to favor the dominance of coral dominance in the experimental patch. These results may be useful in informing expectations for future restoration efforts.
Innovative approaches to the treatment of local recurrent vulvar cancer in patients with lichen sclerosus
Authors: Zharov A. V. , Novikova E. G. , Rerberg A. G. , Kolesnikova E. V. 
Published: May 2023

Background. In recent years, there has been an increase in the incidence of vulvar precancer (lichen sclerosus), as well as vulvar cancer. Since this disorder is rare, treatment planning and therapy itself are often suboptimal, which results in a high recurrence rate. Treatment of patients with local recurrence is even more difficult. Improper therapy often leads to fatal outcomes.Aim. To develop an innovative therapeutic approach to local recurrent vulvar cancer that includes combination (intraarterial and systemic) chemotherapy and surgery.Materials and methods. This pilot study included two patients with a second episode of local recurrent vulvar cancer. The first patient was denied special treatment, whereas the second one was offered abdominoperineal resection of the rectum. At the first stage, the patients received combination chemotherapy; at the second stage, they had combination reconstructive surgeries.Results. Combination chemotherapy was highly effective as demonstrated by the reduction of the recurrent tumor to a resectable size. Combination and reconstructive surgeries allowed us to preform radical treatment and preserve functions of the adjacent organs.Conclusion. Combination treatment was highly effective in patients with local recurrent vulvar cancer, when the tumor was located near the urethra, vagina, and anus or invaded them. Combination chemotherapy ensured good tumor regression, while surgery gave hopes for a favorable outcome.
Explosive Yield Estimation Using Regional Seismic Moment Tensors
Authors: Ford Sean R. , Pasyanos Michael E. , Chiang Andrea 
Published: May 2023

ABSTRACT
We use the Pasyanos and Chiang (2022) data set to calculate the seismic moment M0 for each explosion and use the measured explosive yield W to validate the W∼M0 relationship in Denny and Johnson (1991; hereafter, DJ91). The M0 is corrected by transforming to a potency tensor and applying more appropriate near-source geophysical parameter values in the moment estimate. The mean residual between observed and predicted yield is near zero; however, the standard deviation of the residuals results in an F-value (a 95% confidence factor) of about 5. We re-estimate the coefficients in the DJ91 model and find similar values and only a slight improvement in the F-value. Next, we embark on a similar model selection process as DJ91, allowing for non-cube-root yield scaling and other plausible near-source elastic moduli. As was found by DJ91, the yield dependence is not significantly different from unity, and a cube root assumption is valid. Therefore, we yield scale the seismic moment and test the significance of all plausible explanatory variables. Isotropic moment performs better in the response variable than total moment. The preference for isotropic moment could be due to its relationship to volume change, which would be more directly affected by explosive yield. Surprisingly, we find that the overburden pressure, which is a function of depth, is not a significant parameter in the model. We hypothesize that this is due to the competing depth effects on source asymmetry and the incorporation of depth in the Green’s functions used to calculate the seismic moment tensors. Importantly, this emphasizes that only seismic moment tensor-derived moments should be used in these models. After removing insignificant model parameters, we are left with a simple model to predict explosive yield W^ in kt from isotropic moment MI in N·m, W^=κ−1.4132 100.035626GPMI, in which κ and GP are the near-source bulk modulus and gas porosity in Pa and %, respectively. The F-value for this model is approximately 3.
Pulmonary rehabilitation care: Current perspective
Authors: Kumar Ankit , Kant Surya 
Published: May 2023

Pulmonary rehabilitation is a program that helps individuals with chronic respiratory diseases improve their physical function, quality of life, and overall well-being. The program typically involves a combination of exercise, education, and support to help patients manage their symptoms and improve their respiratory health.Exercise is a crucial component of pulmonary rehabilitation and can help improve cardiovascular health, increase lung function, and reduce shortness of breath. Aerobic exercise, resistance exercise, and flexibility exercise are all important types of exercise used in pulmonary rehabilitation, with patients gradually increasing the intensity and duration of their workouts over time.Breathing techniques are another essential component of pulmonary rehabilitation and can help patients manage their symptoms and improve their overall respiratory function. Techniques such as diaphragmatic breathing, pursed-lip breathing, and controlled coughing can help improve oxygenation, reduce shortness of breath, and improve overall respiratory function.In addition to exercise and breathing techniques, pulmonary rehabilitation programs may also include education and support to help patients better manage their condition. This may include education on medication management, nutrition, stress management, and other topics relevant to respiratory health.Overall, pulmonary rehabilitation is a comprehensive program that can help individuals with chronic respiratory diseases improve their physical function, reduce symptoms, and improve their overall quality of life. By incorporating exercise, breathing techniques, education, and support, pulmonary rehabilitation can help patients better manage their condition and achieve optimal respiratory health.
Clinical & etiological profile of new onset unprovoked seizure in children aged 2 months to 18 years
Authors: Jain Bhupesh , Sankhala Ravikant 
Published: May 2023

Seizure is defined as abnormal paroxysmal neuronal discharge, which is clinically manifested by motor, sensory, autonomic or behavioral disturbances. Seizures are common in pediatrics age group and occur in 10% of children. Less than 1/3of seizures in children are caused by epilepsy. The objective of the study was to determine the clinical and etiological profile of new onset unprovoked seizure in children aged between 2 month to 18 years. A hospital based prospective single centre study at RNT Medical College, Udaipur. 111 patients admitted in Balchikitsalya with new onset unprovoked seizures during one year. Out of 111 patients with new onset unprovoked seizures, majority of patients were between 1-5 years of age with male predominance. In which most common diagnosis was seizure disorder in 78 pts (70.2%) [Generalised 76 pts (97.4%) &#62; Focal 2 pts (2.6%)] followed by 13.5% hypocalcemic seizure, 8.1% hypoglycemic seizure. Other diagnosis was tuberous sclerosis (2.7%), white matter changes (1.8%), adrenoleukodystrophy (0.9%), arachnoid cyst (0.9%), tuberculoma (0.9%) and HIE changes (0.9%). EEG abnormality was seen in 46% of patients. Hyponatremia (36%) was significantly associated with abnormal EEG changes. MRI was done in 38.7% of the patients, out of which, abnormality was seen in only 8.6% of the children. Seizure is mainly diagnosed clinically and EEG can be normal in many patients. First episode of unprovoked seizure was common in age group of 1-5 years. EEG and Neuroimaging is useful for better diagnosis, treatment can be started on clinical diagnosis.