bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altimetry-derived tide model for improved tide and water level forecasting along the European continental shelf
Authors: Hart-Davis Michael G. , Laan Stendert , Schwatke Christian , Backeberg Björn , Dettmering Denise , Zijl Firmijn , Verlaan Martin , Passaro Marcello , Seitz Florian 
Published: July 2023

AbstractWith the continued rise in global mean sea level, operational predictions of tidal height and total water levels have become crucial for accurate estimations and understanding of sea level processes. The Dutch Continental Shelf Model in Delft3D Flexible Mesh (DCSM-FM) is developed at Deltares to operationally estimate the total water levels to help trigger early warning systems to mitigate against these extreme events. In this study, a regional version of the Empirical Ocean Tide model for the Northwest European Continental Sea (EOT-NECS) is developed with the aim to apply better tidal forcing along the boundary of the regional DCSM-FM. EOT-NECS is developed at DGFI-TUM by using 30 years of multi-mission along-track satellite altimetry to derive tidal constituents which are estimated both empirically and semi-empirically. Compared to the global model, EOT20, EOT-NECS showed a reduction in the root-square-sum error for the eight major tidal constituents of 0.68 cm compared to in situ tide gauges. When applying constituents from EOT-NECS at the boundaries of DCSM-FM, an overall improvement of 0.29 cm was seen in the root-mean-square error of tidal height estimations made by DCSM-FM, with some regions exceeding a 1 cm improvement. Furthermore, of the fourteen constituents tested, eleven showed a reduction of RMS when included at the boundary of DCSM-FM from EOT-NECS. The results demonstrate the importance of using the appropriate tide model(s) as boundary forcings, and in this study, the use of EOT-NECS has a positive impact on the total water level estimations made in the northwest European continental seas.
Complementarity formulation of games with random payoffs
Authors: Riccardi Rossana , Oggioni Giorgia , Allevi Elisabetta , Lisser Abdel 
Published: July 2023

AbstractWe consider an n-player non-cooperative game where the payoff function of each player follows a multivariate distribution. This formulation is adopted to model a zonal electricity market in which generators operate by running conventional and renewable-based plants. The players in the market compete as in a Cournot model. We formulate this problem as a chance-constrained game by defining the payoff function of each player using a chance constraint. A full empirical analysis has been conducted on the Italian electricity market to test the impact of renewable generators in the light of decarbonization of the market and the impact of the volatility of the cost of conventional plants, mainly related to the volatility of gas prices. We finally test the robustness of the chance constraint formulation with an out of sample analysis.
Comparison between cavernous sinus and jugular vein as post mortem sampling sites for blood metabolic profiles in wild red deer (Cervus elaphus)
Authors: Comazzi Stefano , Guanziroli Sharon , Giordano Alessia , Formenti Nicoletta , Trogu Tiziana , Corlatti Luca , Luzzago Camilla , Ferrari Nicola 
Published: July 2023

AbstractCollection from jugular vein (JV) or intrathoracic cavity is the traditional procedure for blood sampling dead wildlife, but it is often source of preanalytical biases. Cavernous sinus of dura mater (CS) is an alternative site for withdrawal that may help to solve these issues but it has been used only for serology, while no data are available for biochemistry. This work compares metabolic profiles from CS and JV blood in red deer Cervus elaphus, to evaluate the usability of CS for metabolic profiling. A total of 134 deer were sampled in the frame of a culling program within the Stelvio National Park (Central Italian Alps). Hemolysis was statistically lower in CS than JV with 88% vs 44% of samples suitable for biochemistry. Thirty-six couples of poorly hemolytic sera were used for biochemical analysis: total protein, albumin, urea, triglycerides, total cholesterol, non-esterified fatty acids (NEFA), betahydroxybutyrate (BOHB), calcium, and phosphorus. Statistical differences were found for protein, albumin, cholesterol, and calcium; agreement was found for urea, NEFA, BOHB, and phosphorus while for total protein, albumin, cholesterol, and calcium, CS showed lower concentrations with both constant and proportional biases. These results may be related to a higher impact of water dilution in CS. Although the lower protein concentration in CS cannot significantly influence the serological results, caution is required for potential false negative results when antibody levels are close to cut-off values. CS leads to a higher percentage of samples suitable for metabolic profiles but results should be compared with adequate reference intervals.
Scheduling activities in project network with feeding precedence relations: an earliest start forward recursion algorithm
Authors: Bianco Lucio , Caramia Massimiliano , Giordani Stefano , Salvatore Alessio 
Published: July 2023

AbstractIn some production processes, the effort associated with a certain activity for its execution can vary over time. In this case, the amount of work per time unit devoted to each activity, so as its duration, is not univocally determined. This kind of problem can be represented by an activity project network with the so-called feeding precedence relations, and activity variable execution intensity. In this paper, we propose a forward recursion algorithm able to find the earliest start and finish times of each activity, in $$O(m \log n)$$

O
(
m
log
n
)

time, with n and m being the number of activities and the number of precedence relations, respectively. In particular, this requires the calculation of the (optimal) execution intensity profile, for each activity, that warrants the earliest start schedule and the minimum completion time of the project.
Weighted Colimits of 2-Representations and Star Algebras
Authors: Stroiński Mateusz 
Published: July 2023

AbstractWe apply the theory of weighted bicategorical colimits to study the problem of existence and computation of such colimits of birepresentations of finitary bicategories. The main application of our results is the complete classification of simple transitive birepresentations of a bicategory studied previously by Zimmermann. The classification confirms a conjecture he has made.
Modification of the SSG/LRR-Omega Model for Turbulent Boundary Layer Flows in an Adverse Pressure Gradient
Authors: Knopp Tobias , Reuther Nico , Novara Matteo , Schanz Daniel , Schülein Erich , Schröder Andreas , Kähler Christian J. 
Published: July 2023

AbstractA modification of the RANS turbulence model SSG/LRR-$$\omega $$
ω
for turbulent boundary layers in an adverse pressure gradient is presented. The modification is based on a wall law for the mean velocity, in which the log law is progressively eroded in an adverse pressure gradient and an extended wall law (designated loosely as a half-power law) emerges above the log law. An augmentation term for the half-power law region is derived from the analysis of the boundary-layer equation for the specific rate of dissipation $$\omega $$
ω
. An extended data structure within the RANS solver provides, for each viscous wall point, the field points on a wall-normal line. This enables the evaluation of characteristic boundary layer parameters for the local activation of the augmentation term. The modification is calibrated using a joint DLR/UniBw turbulent boundary layer experiment. The modified model yields an improved predictive accuracy for flow separation. Finally, the applicability of the modified model to a 3D wing-body configuration is demonstrated.
Is de-escalation of treatment by omission of radiotherapy associated with fear of cancer recurrence in women with early breast cancer? An exploratory study
Authors: Stafford Lesley , Sinclair Michelle , Butow Phyllis , Hughes Janemary , Park Allan , Gilham Leslie , Rose Allison , Mann G. Bruce 
Published: July 2023

Abstract
Purpose
Safe de-intensification of adjuvant radiotherapy (RT) for early breast cancer (BC) is currently under evaluation. Little is known about the patient experience of de-escalation or its association with fear of cancer recurrence (FCR), a key issue in survivorship. We conducted a cross-sectional study to explore this association.

Methods
Psychometrically validated measures including the Fear of Cancer Recurrence Inventory-Short Form were completed by three groups of women with early BC: Women in the PROSPECT clinical trial who underwent pre-surgical MRI and omitted RT (A), women who underwent pre-surgical MRI and received RT (B); and women who received usual care (no MRI, received RT; C). Between group differences were analysed with non-parametric tests. A subset from each group participated in a semi-structured interview. These data (n = 44) were analysed with directed content analysis.

Results
Questionnaires from 400 women were analysed. Significantly lower FCR was observed in Group A (n = 125) than in Group B (n = 102; p = .002) or Group C (n = 173; p = .001), and when participants were categorized by RT status (omitted RT vs received RT; p < .001). The proportion of women with normal FCR was significantly (p < .05) larger in Group A (62%) than in Group B (35%) or Group C (40%). Two qualitative themes emerged: ‘What I had was best’ and ‘Coping with FCR’.

Conclusions
Omitting RT in the setting of the PROSPECT trial was not associated with higher FCR than receiving RT. Positive perceptions about tailored care, lower treatment burden, and trust in clinicians appear to be protective against FCR.
Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker
Authors: Mayer Marcel , Nachtsheim Lisa , Prinz Johanna , Shabli Sami , Suchan Malte , Klußmann Jens Peter , Quaas Alexander , Arolt Christoph , Wolber Philipp 
Published: July 2023

AbstractMany locally advanced and metastatic salivary gland carcinomas (SGC) lack therapeutic targets. Enfortumab vedotin, an antibody–drug conjugate binding to Nectin-4, recently gained FDA approval for third-line urothelial carcinoma. Therefore, the aim of this study was to assess the expression of Nectin-4 in primary SGC and corresponding lymph node metastases and to correlate it with clinicopathological data. Immunohistochemical staining for Nectin-4 was performed for patients who had undergone surgery with curative intent for primary SGC of the parotid or submandibular gland in a tertiary referral center between 1990 and 2019. One hundred twenty-two primary SGC and twenty corresponding lymph node metastases were included. Nectin-4 was expressed in 80.3% of primary SGC with a mean Histo(H-)score of 61.2 and in 90.0% of lymph node metastases with a mean H-score of 75.6. A moderate or high Nectin-4 expression was found in 25.9% of salivary duct carcinomas (SaDu) and in 30.7% of adenoid cystic carcinomas (ACC). SaDu patients with a lower T-stage (p = 0.04), no loco-regional lymph node metastases (p = 0.049), no vascular invasion (p = 0.04), and no perineural spread (p = 0.03) showed a significantly higher mean Nectin-4 H-score. There was a statistical tendency towards a more favorable disease-free survival among SaDu patients with a higher Nectin-4 expression (p = 0.09). Nectin-4 is expressed in SGC and therefore represents a potential therapeutic target, especially in entities with a high rate of local recurrence and metastatic spread such as SaDu and ACC.
Characterising a genetic stronghold amidst pervasive admixture: Morelet’s crocodiles (Crocodylus moreletii) in central Yucatan
Authors: Barão-Nóbrega José António L. , González-Jáuregui Mauricio , Padilla-Paz Sergio , Maher Kathryn H. , Martínez-Arce Arely , Cedeño-Vázquez José Rogelio , Jehle Robert 
Published: July 2023

AbstractWhen backcrosses are fertile, interbreeding between endangered taxa can lead to the admixture of gene pools under threat. One such case pertains to the Mesoamerican crocodile Crocodylus moreletii, a species which shows strong signatures of both recent hybridisation and historic intogression with the American crocodile C. acutus across large parts of its range. In the present paper, we use RAD-seq derived SNPs (4980 nuclear and seven mtDNA loci) to demonstrate that C. moreletii populations inhabiting the region of Calakmul in central Yucatan (Mexico) are rather unaffected by hybridization, despite being surrounded by coastal areas where pervasive admixture has previously been documented. All (based on fastSTRUCTURE) and 96% (based on NGSadmix) of 84 genotyped individuals from 18 sampled waterbodies (locally termed aguadas) were free from nuclear introgression of C. acutus DNA at at threshold of 0.95. Seven individuals (8%) possessed a C. acutus mtDNA haplotype, five of which were derived from two adjacent, rather peripheral aguadas. Spatial inferences based on a DAPC and fineRADstructure further showed that the region of Calakmul is inhabited by three genetic clusters spanning across a set of distinct aguadas each. Taken together, our findings reveal that central Yucatan contains the currently largest documented stronghold of C. moreletii populations only marginally affected by introgression, which has major implications for the conservation management of this important flagship species.
Proton irradiation of plastic scintillator bars for POLAR-2
Authors: Mianowski Slawomir , De Angelis Nicolas , Brylew Kamil , Hulsman Johannes , Kowalski Tomasz , Kusyk Sebastian , Mianowska Zuzanna , Mietelski Jerzy , Rybka Dominik , Swakon Jan , Wrobel Damian 
Published: July 2023

AbstractPOLAR-2, a plastic scintillator based Compton polarimeter, is currently under development and planned for a launch to the China Space Station in 2025. It is intended to shed a new light on our understanding of Gamma-Ray Bursts by performing high precision polarization measurements of their prompt emission. The instrument will be orbiting at an average altitude of 383 km with an inclination of 42° and will be subject to background radiation from cosmic rays and solar events. In this work, we tested the performance of plastic scintillation bars, EJ-200 and EJ-248M from Eljen Technology, under space-like conditions, that were chosen as possible candidates for POLAR-2. Both scintillator types were irradiated with 58 MeV protons at several doses from 1.89 Gy(corresponding to about 13 years in space for POLAR-2) up to 18.7 Gy, that goes far beyond the expected POLAR-2 life time. Their respective properties, expressed in terms of light yield, emission and absorption spectra, and activation analysis due to proton irradiation are discussed. Scintillators activation analyses showed a dominant contribution of β + decay with a typical for this process gamma-ray energy line of 511 keV.
Starch serves as an overflow product in the regulation of carbon allocation in strawberry leaves in response to photosynthetic activity
Authors: Nakai Hiromi , Yasutake Daisuke , Hidaka Kota , Nomura Koichi , Eguchi Toshihiko , Yokoyama Gaku , Hirota Tomoyoshi 
Published: July 2023

AbstractThe carbon allocation in source leaves between sucrose and starch is an important mechanism that affects plant productivity. We previously found that strawberry plants accumulate starch in response to excess carbon supply from photosynthesis compared with translocation and sucrose storage capacity in source leaves. However, because these data were acquired from three separate cultivation seasons in field conditions, seasonal impacts could not be ruled out. Therefore, herein, we aimed to investigate the role of starch in carbon allocation in strawberry leaves and to explore whether the relationship between sucrose and starch reported in our previous study is an inherent characteristic that is independent of seasonal variations. To prevent seasonal influences, carbohydrate dynamics in strawberry leaves were studied under controlled environmental conditions with high (High) and low (Low) photosynthetic activity. During the day, both sucrose and starch concentrations increased in the High treatment, but starch concentration increased only marginally in the Low treatment. Furthermore, starch production was enhanced in the High treatment when sucrose concentration exceeded 150 mmol C m− 2. Consistent with previous findings, the current findings indicated that photosynthetically fixed carbon is initially allocated to sucrose; however, when photosynthetic activity increases and leaf sucrose concentration exceeds its storage capacity, the excess carbon is then allocated to starch. This study provides strong evidence that, regardless of season, starch serves as an overflow product with sucrose storage capacity as a threshold during carbon allocation in strawberry leaves.
Changes of dysfunctional lens index before and after implantable collamer lens V4c implantation in patients with moderate-to-high myopia
Authors: Cao Weifang , Zhang Suhua , Liu Qian , Zhou Jing , Yuan Xiaoyong 
Published: July 2023

Abstract
Background
Dysfunctional lens index (DLI) changing is rarely reported after implantable collamer lens (ICL) implantation. In the current research, we hope to investigate the changes of DLI by ray-tracing aberrometry before and after implantation of the posterior chamber phakic implantable collamer lens with a central artificial hole for patients with moderate-to-high myopia.

Methods
This retrospective, observational case series included 206 eyes of 104 patients with moderate-to-high myopia who underwent ICL V4c implantation. Data were collected on ocular indicators preoperatively and at 1 day, 1, 3, and 6 months postoperatively. The i-Trace Visual Functional Analyzer was used to assess the DLI measurement.

Results
The overall values of safety index and efficacy index were both more than 1. Preoperatively, the mean spherical equivalent (SE) of included 206 eyes was − 10.77 ± 3.46 diopter (D). Then at 1-day postoperation, the mean SE was − 0.22 ± 0.55 D, and barely changed from 1 day to 6 months postoperatively. Although the endothelial parameters had no significant differences between preoperation and postoperation, the mean loss of endothelial cells was 0.74 ± 0.98% at 6 months. Regarding the vault, there was a significant difference between each time of follow-up (P < 0.001). The mean of the vault decreased 109.6 ± 13.5 µm from 1-day post-op to 6 months post-op. The DLI values were 3.70, 9.26, 10.00, and 9.68 at baseline, 1, 3, and 6 months, respectively (P < 0.001), but no significant differences were found between 1, 3, and 6 months postoperatively (P > 0.05). The preoperative lnDLI showed a significant positive linear correlation (r = 0.621, P < 0.001) with the preoperative spherical equivalent (SE). The lnDLI was negatively correlated with the axial length (r = − 0.462, P < 0.001), corneal thickness (r = − 0.207, P = 0.003), preoperative LogMAR UDVA (r = − 0.189, P = 0.006), and preoperative LogMAR CDVA (r = − 0.306, P < 0.001).

Conclusions
The postoperative refractive parameters were confirmed excellent in efficacy, predictability, and stability in half a year. The DLI was significantly improved after the ICL V4c implantation in patients with moderate-to-high myopia and showed good stability during the follow-up periods. The DLI deserves a more comprehensive understanding and application in clinical services.
A Comparative Analysis of the Full and Short Versions of the Social Responsiveness Scale in Estimating an Established Autism Risk Factor Association in ECHO: Do we Get the Same Estimates?
Authors: Patti Marisa A. , Ning Xuejuan , Hosseini Mina , Croen Lisa A. , Joseph Robert M. , Karagas Margaret R. , Ladd-Acosta Christine , Landa Rebecca , Messinger Daniel S. , Newschaffer Craig J. , Nguyen Ruby , Ozonoff Sally , O’Shea T. Michael , Schmidt Rebecca J. , Trevino Cindy O. , Lyall Kristen 
Published: July 2023

Abstract
Purpose
Prior work developed a shortened 16-item version of the Social Responsiveness Scale (SRS), a quantitative measure of social communication and autism spectrum disorder (ASD)-related traits. However, its properties for use in risk factor estimation have not been fully tested compared to the full SRS. We compared the associations between gestational age (previously established risk factor for ASD) and the 65-item “full” and 16-item “short” versions of the SRS to test the shortened version’s ability to capture associations in epidemiologic analyses of ASD risk factors.

Methods
We used data from participants in the Environmental influences on Child Health Outcomes (ECHO) Program (n = 2,760). SRS scores were collected via maternal/caregiver report when children were aged 2.5–18 years. We compared estimates of associations between gestational age and preterm birth between the full and short SRS using multivariable linear regression, quantile regression, and prediction methods.

Results
Overall, associations based on full and short SRS scores were highly comparable. For example, we observed positive associations between preterm birth with both full ($$\beta$$=2.8; 95% CI [1.7, 4.0]) and short ($$\beta$$=2.9; 95% CI [1.6, 4.3]) SRS scores. Quantile regression analyses indicated similar direction and magnitude of associations across the distribution of SRS scores between gestational age with both short and full SRS scores.

Conclusion
The comparability in estimates obtained for full and short SRS scores with an “established” ASD risk factor suggests ability of the shortened SRS in assessing associations with potential ASD-related risk factors and has implications for large-scale research studies seeking to reduce participant burden.
School Attendance Problems Among Children with Neurodevelopmental Conditions One year Following the Start of the COVID-19 Pandemic
Authors: Totsika Vasiliki , Kouroupa Athanasia , Timmerman Amanda , Allard Amanda , Gray Kylie M. , Hastings Richard P. , Heyne David , Melvin Glenn A. , Tonge Bruce 
Published: July 2023

AbstractPurpose: The present study investigated school absence among 1,076 5–15 year-old children with neurodevelopmental conditions (intellectual disability and/or autism) approximately one year following the start of COVID-19 in the UK. Methods: Parents completed an online survey indicating whether their child was absent from school during May 2021 and the reason for each absence. Multi-variable regression models investigated child, family and school variables associated with absenteeism and types of absenteeism. Qualitative data were collected on barriers and facilitators of school attendance. Results: During May 2021, 32% of children presented with persistent absence (missing ≥ 10% of school). School refusal and absence due to ill-health were the most frequent types of absence, accounting for 37% and 22% of days missed, respectively. COVID-19 related absence accounted for just 11% of days missed. Child anxiety was associated with overall absenteeism and with days missed because of school refusal. Parent pandemic anxiety and child conduct problems were not associated with school absenteeism. Hyperactivity was associated with lower levels of absenteeism and school refusal but higher levels of school exclusion. A positive parent-teacher relationship was associated with lower levels of absenteeism, school refusal and exclusion. Child unmet need in school was the most frequently reported barrier to attendance while COVID-19 was one of the least frequently reported barriers. Conclusion: COVID-19 had a limited impact on school attendance problems during this period. Findings highlighted the role of child mental health in different types of absence and the likely protective role of a positive parent-teacher relationship.