bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of MitraClip for nonobstructive hypertrophic cardiomyopathy with mixed severe mitral valve regurgitation
Authors: Zeng Jie , Shu Qinglan , Lu Cong , Wang Yi 
Published: January 2023

AbstractReports on the treatment of nonobstructive hypertrophic cardiomyopathy (HCM) and severe mitral valve regurgitation (MR) with transcatheter edge‐to‐edge repair (TEER) are rare. Herein, we present the case of a 68‐year‐old Chinese man with nonobstructive HCM admitted to our hospital with dyspnoea [New York Heart Association (NYHA) functional Class IV]. Transthoracic echocardiography indicated severe MR in addition to asymmetric hypertrophy of the left ventricle. Despite administering maximal medical therapy for heart failure, the symptoms were not alleviated; because of the high risk of open surgery, TEER was performed for MR. After 4 months of follow‐up, the patient showed a significant improvement in symptoms. Herein, we also discuss and review the pathophysiology and treatment strategies for HCM patients with heart failure.
Face validity of the ICD‐10 criteria of substance abuse and dependence for patients prescribed cannabis‐based medicines for chronic pain—A survey of pain medicine physicians in Canada, Germany and Israel
Authors: Lauff Sören , Petzke Frank , Brill Silviu , Schouten Leonie , Fitzcharles Mary‐Ann , Pereira John X. , Häuser Winfried 
Published: January 2023

AbstractBackground and ObjectiveA major concern with cannabis‐based medicines (CbM) and medical cannabis (MC) is the risk of abuse and dependence. The face validity of the International Classification of Diseases (ICD‐10) criteria for cannabis dependence in patients prescribed CbM for chronic pain has not been assessed.Databases and Data TreatmentPhysicians from Canada, Germany and Israel were recruited via the mailing lists of national pain societies. To be eligible, physicians had to have prescribed CbM for chronic pain treatment in the past 12 months. Participants were asked to rate the appropriateness of items adapted from the substance use module of the Composite International Diagnostic Interview Version 3.0 to assess dependence in the context of chronic pain treatment with CbM and the appropriateness of two additional items. In case of disagreement, participants were asked to give reasons. Furthermore, they were asked to suggest potential additional criteria.ResultsOn average 69.0% of 178 participating physicians indicated agreement with the appropriateness of the ICD‐10 criteria, while 20.6% indicated disagreement. The highest disagreement rate was observed for the item on repeated use despite legal problems (35.4% disagreement or strong disagreement). Reasons for disagreement were summarized into six content categories using qualitative methods of analysis. Additional criteria suggested by participants were summarized into 10 content categories.ConclusionsA collaboration of psychiatrists and pain physicians is required to define criteria and develop instruments to capture abuse and dependence of CbM in chronic pain patients.SignificanceSixty‐nine per cent of 178 pain medicine physicians in Canada, Germany and Israel who participated in a survey on the appropriateness of the ICD‐10 criteria for cannabis abuse and dependence for patients prescribed cannabis‐derived products for chronic pain assessed the criteria as appropriate, whereas 20.6% deemed the criteria as not appropriate.
Nuances in modeling and impedance‐inspired control of shake tables for tracking ground‐motion trajectories
Authors: Parsi Sai Sharath , Sivaselvan M. V. , Whittaker Andrew S. 
Published: January 2023

AbstractServo‐hydraulic shake tables are widely used for simulating earthquake shaking in a laboratory environment. Control procedures for shake‐table testing and the associated mathematical models are well documented. An evaluation of such models revealed nuances regarding actuator control, which led to the development of the simple, easy to implement, robust shake‐table controller described in this paper. This controller design recognizes that (i) differential pressure feedback in actuator control is highly beneficial in reducing the consequences of hydraulic‐related nonlinearities and other modeling uncertainties, (ii) the bandwidth over which differential pressure feedback is useful is limited by the sampling frequency of the chosen digital controller, (iii) a linear model predicts shake‐table response with high fidelity across a broad frequency range for a carefully chosen differential pressure gain and a sufficiently large controller sampling frequency, and (iv) shake‐table transfer functions derived from such a linear model are highly effective in designing a feedforward controller. Further, and perhaps most importantly, the controller utilizes real‐time feedback of the reaction force from the test article to account for table‐test article interaction. The three clear advantages of the proposed shake‐table controller are (i) the test‐article dynamics are decoupled from the control design, (ii) the need for offline/online iterative tuning, which is often ground motion‐ and test article‐specific, is minimized, and (iii) control procedures for shake tables can be standardized, all of which are validated in this paper through a series of experiments performed on a uniaxial hydraulic shake table.
Joint analysis of multiple phenotypes for extremely unbalanced case‐control association studies
Authors: Xie Hongjing , Cao Xuewei , Zhang Shuanglin , Sha Qiuying 
Published: January 2023

AbstractIn genome‐wide association studies (GWAS) for thousands of phenotypes in biobanks, most binary phenotypes have substantially fewer cases than controls. Many widely used approaches for joint analysis of multiple phenotypes produce inflated type I error rates for such extremely unbalanced case‐control phenotypes. In this research, we develop a method to jointly analyze multiple unbalanced case‐control phenotypes to circumvent this issue. We first group multiple phenotypes into different clusters based on a hierarchical clustering method, then we merge phenotypes in each cluster into a single phenotype. In each cluster, we use the saddlepoint approximation to estimate the p value of an association test between the merged phenotype and a single nucleotide polymorphism (SNP) which eliminates the issue of inflated type I error rate of the test for extremely unbalanced case‐control phenotypes. Finally, we use the Cauchy combination method to obtain an integrated p value for all clusters to test the association between multiple phenotypes and a SNP. We use extensive simulation studies to evaluate the performance of the proposed approach. The results show that the proposed approach can control type I error rate very well and is more powerful than other available methods. We also apply the proposed approach to phenotypes in category IX (diseases of the circulatory system) in the UK Biobank. We find that the proposed approach can identify more significant SNPs than the other viable methods we compared with.
Landscape spatial configuration influences phosphorus but not nitrate concentrations in agricultural headwater catchments
Authors: Dupas Rémi , Casquin Antoine , Durand Patrick , Viaud Valérie 
Published: January 2023

AbstractLandscape organized (or structured) heterogeneity influences hydrological and biogeochemical patterns across space and time. We developed landscape indices that describe the spatial configuration of nutrient sources and sinks as a function of their hydrological distance to the stream (lateral dimension) or to the outlet (longitudinal dimension) and their intersection with flow‐accumulation areas. Using monthly nitrate, total phosphorus (TP), soluble reactive phosphorus (SRP) and daily discharge (Q) data from 221 rural catchments (1–300 km2) from 2010–2020, we observed higher variability in flow‐weighted mean concentrations in smaller catchments than in larger ones. The variability in landscape configurations also decreased with increasing catchment size. A landscape configuration index, calculated as mean arable land use weighted by spatial data on hydrological distance and flow accumulation, improved prediction of TP and SRP, but not nitrate, compared to the unweighted mean arable land use. We conclude that landscape configuration influences phosphorus transfer more than nitrate transfer, and that flow‐accumulation zones and riparian areas are critical source areas for TP and SRP, respectively. By contrast, landscape spatial configuration in the lateral (upslope–downslope) and longitudinal (upstream–downstream) dimensions did not have an identifiable influence on nutrients temporal dynamics. The indices developed in this study can help design landscapes that minimize diffuse phosphorus losses to streams and show that landscape management is not a first order control for nitrate losses.
Modelling rainfall‐induced phosphorus loss with eroded clay and surface runoff
Authors: Chen Minghong , Li Yun , Wang Chaozi , Walter M. Todd , Huang Lei 
Published: January 2023

AbstractPhosphorus (P) loss via runoff will reduce soil fertility and cause water eutrophication. Although P is lost as both particulate phosphorus (PP) and soluble phosphorus (SP), the existing P transport models for landscapes rarely consider PP and its exchange with surface runoff. We developed an integrated P transport model which coupled both SP and PP transport mechanisms based on the Rose–Gao model and assessed it via laboratory experiments. We also introduced a temporal varying P partition coefficient Kd into the model to reveal the impacts of rapid changes in the water environment on P adsorption and desorption. Experiments using kaolinite mixed soil and montmorillonite mixed soil were conducted under artificial rainfall events. The results show that the P transport model simulates the concentrations of eroded sediment, SP, and PP in surface runoff, with good agreement with the measured values (all R2 > 0.88). Kaolinite mixed soil had larger sediment and SP concentrations in the runoff than montmorillonite mixed soil. In addition, compared with the no Kd model (Gao model) and the constant Kd model, our model provided simulation results that most closely matched the experimental data. Considering the influence of eroded sediment and the P dynamic partitioning between sediment and water to the surface, the P transport model can provide an effective tool for P dynamics with water and sediment in surface runoff.
Toxicology and digestibility of Chlamydomonas debaryana green algal biomass
Authors: Murbach Timothy S. , Glávits Róbert , Jayasena Shyamali , Moghadam Maragheh Niloofar , Endres John R. , Hirka Gábor , Goodman Richard E. , Vértesi Adél , Béres Erzsébet , Pasics Szakonyiné Ilona 
Published: January 2023

AbstractThere is an economic interest, both for food security and for the non‐meat‐eating population, in the development of novel, sustainable sources of high‐quality protein. The green algae Chlamydomonas reinhardtii has already been developed for this purpose, and the closely related species, Chlamydomonas debaryana, is a complementary source that also presents some additional advantages, such as reduced production cost. To determine whether C. debaryana may have a similar safety profile to that of C. reinhardtii, a wild type strain was obtained, designated TS04 after confirmation of its identity, and subjected to a battery of preclinical studies. Genetic toxicity was evaluated using a bacterial reverse mutation test, an in vitro mammalian chromosomal aberration test, and an in vivo mammalian micronucleus test in a mouse model. No genotoxic potential (e.g., mutagenicity and clastogenicity) was observed in these tests under the employed conditions up to maximum recommended concentrations or doses. To assess general toxicity, a 90‐day repeated‐dose oral toxicity study was conducted in rats. No mortality or adverse effects were observed, and no target organs were identified up to the maximum feasible dose, due to solubility, of 4,000 mg/kg bw/day. The no‐observed‐adverse‐effect level was determined as the highest dose tested. A digestibility study in simulated gastric fluid was conducted and determined that TS04 has low allergenic potential, exhibiting rapid digestion of proteins. Due to the negative results of our evaluation, it is reasonable to proceed with further development and additional investigations to contribute towards a safety assessment of the proposed use in food for human consumption.
Rethinking worrying about the stock market, but instead, anxious about employment
Authors: Li Mingda , Rapp William V. , Chen Yi 
Published: January 2023

AbstractUsing Engleberg's and Parsons's (2016) study (E&P) relating stock prices and hospital admissions for NJ, mental disease admits appear affected. One deviation decrease in returns of NJ/NYC‐based companies increases average daily mental disorder admits by month by 1.7% above the expected level. However, the study raises issues concerning E&P's state‐based stock price verses hospital admit conclusions by examining NJ counties’ unemployment rates compared to stock market effects on hospital admissions. Stock market effects are weak in rural and low‐income counties unless near NYC. Further, employment is a stronger explanation than stock prices and even their combination for all counties. A one percent decrease in monthly employment rate increases admits above the expected level by 3.6% across all counties. Stock prices thus seem an employment or economic proxy for NJ, rather than an independent variable.
Hyperfunction variant rs708035 of interleukin 1 receptor‐associated kinases 2 gene involved in the predisposition of leprosy infection
Authors: Saleem Saima , Zia Mutaher , Siddiqui Farhatulain , Ghouri Maham , Kulsoom Ume , Kawal Sidra , Fatima Sehrish , Zehra Sitwat 
Published: January 2023

AbstractBackgroundMycobacterium leprae (slow‐growing bacteria) is the etiological agent for leprosy infection, which is a chronic granulomatous disease. Symptoms initiate with the loss of sensation in the affected areas, which can lead to severe injuries, cuts and burns. IRAK2 (interleukin‐1 receptor‐associated kinases 2) is reported to function in the regulation of the NFκB pathway. The frequency of the IRAK2 polymorphism (rs708035) was unknown in the Pakistani population. Therefore, the study was designed to identify the role of the rs708035 SNP (single nucleotide polymorphism) in susceptibility to leprosy.MethodologyThe case–control study was designed, and participants were selected by Ridley–Jopling Classification. Blood samples from healthy individuals and patients were collected after ethical approval. Genomic DNA was extracted for the amplification of selected polymorphisms by tetra‐primer amplification refractory mutation system polymerase chain reaction. The desired products were observed via agarose gel (2.5%) electrophoresis followed by data analysis using bioinformatics tools (SNP Stats and SHEsis) and statistical tests (odds ratio, OR, and chi square).ResultsThe study revealed that the mutant genotype (TT) was found to be frequent among cases (22.80%) in comparison with the controls (1.66%). The SNP rs708035 was significantly associated with the progression of leprosy (χ2 = 17.62, p < 0.0001). The targeted SNP significantly increases the risk of leprosy 2.3 times (OR = 2.3119, 95% CI 1.2729–4.1989, p < 0.01). The genetic model also confirms the significant association of the A/T genotype with leprosy in the over‐dominant model (OR = 2.83, 95% CI 1.16–6.89, p < 0.001).ConclusionsThe study revealed a significant association of the targeted SNP with leprosy and provided baseline data regarding the association of rs708035. The current research could be utilized for the preparation of biomarkers by considering a larger sample size.Highlights

The patients suffering from leprosy faced various comorbidities, including hypertension and diabetes.
The study reports for the first time a significant association of interleukin 1 receptor associated kinases 2 (IRAK2) single nucleotide polymorphism (SNP) rs708035 among the Pakistani population (Karachi).
The current study provides baseline data to develop diagnostic biomarkers for early detection of leprosy.
ATP7A‐related copper transport disorders: A systematic review and definition of the clinical subtypes
Authors: De Feyter S. , Beyens A. , Callewaert B. 
Published: January 2023

AbstractIn patients with ATP7A‐related disorders, counseling is challenging due to clinical overlap between the entities, the absence of predictive biomarkers and a clear genotype‐phenotype correlation. We performed a systematic literature review by querying the MEDLINE and Embase databases identifying 143 relevant papers. We recorded data on the phenotype and genotype in 162 individuals with a molecularly confirmed ATP7A‐related disorder in order to identify differentiating clinical criteria, evaluate genotype‐phenotype correlations and propose management guidelines.Early seizures are specific for classical Menkes disease (CMD), that is characterized by early‐onset neurodegenerative disease with high mortality rates. Ataxia is an independent indicator for atypical Menkes disease, that shows better survival rates than CMD. Bony exostoses, radial head dislocations, herniations and dental abnormalities are specific for occipital horn syndrome (OHS) that may further present with developmental delay and connective tissue manifestations. Intracranial tortuosity and bladder diverticula, both with high risk of complications, are common among all subtypes. Low ceruloplasmin is a more sensitive and discriminating biomarker for ATP7A‐related disorders than serum copper. Truncating mutations are frequently associated with CMD, in contrast with splice site and intronic mutations which are more prevalent in OHS.
Phenotypic characterization of phage vB_vcM_Kuja
Authors: Maina Alice N. , Mwaura Francis B. , Wagacha John M. , Jumba Miriam , Aziz Ramy K. , Nour El‑Din Hanzada T. 
Published: January 2023

AbstractBacteriophage therapy targeting the increasingly resistant Vibrio cholerae is highly needed. Hence, studying the phenotypic behavior of potential phages under different conditions is a prerequisite to delivering the phage in an active infective form. The objective of this study was to characterize phage VP4 (vB_vcM_Kuja), an environmental vibriophage isolated from River Kuja in Migori County, Kenya in 2015. The phenotypic characteristics of the phage were determined using a one‐step growth curve, restriction digestion profile, pH, and temperature stability tests. The results revealed that the phage is stable through a wide range of temperatures (20−50°C) and maintains its plaque‐forming ability at pH ranging from 6 to 12. The one‐step growth curve showed a latent period falling between 40 and 60 min, while burst size ranged from 23 to 30 plaque‐forming units/10 µl at the same host strain. The restriction digestion pattern using EcoRI, SalI, HindIII, and XhoI enzymes showed that HindIII could cut the phage genome. The phage DNA could not be restricted by the other three enzymes. The findings of this study can be used in future studies to determine phage−host interactions.
Isolation and identification of dipeptidyl peptidase‐IV inhibitory peptides from Sacha inchi meal
Authors: Zhang Aiyuan , Wang Kai , Liu Xiaofei , Zhang Xuewu 
Published: January 2023

AbstractBACKGROUNDSacha inchi meal (SIM) is a by‐product of oil processing. Our previous studies showed that SIM hydrolysates exhibited dipeptidyl peptidase‐IV (DPP‐IV) inhibition activity. The objective of the present work was to identify and characterize the bioactive peptides from protein hydrolysates of SIM; enzyme kinetics and peptide–enzyme interaction were also investigated.RESULTSFrom SIM hydrolysates, ten peptides responsible for the activity were identified: GPSRGF (GF‐6), FPILSPDPA (FA‐9), APYRRGGKI (AI‐9), WPYH (WH‐4), DPATWLALPT (DT‐10), NPEDEFRQQ (NQ‐9), APESKPVGV (AV‐9), LEWRDR (LR‐6), APVYWVQ (AQ‐7) and LLMWPY (LY‐6). The IC50 values of five peptides (GF‐6, WH‐4, AQ‐7, AV‐9 and LY‐6) with better inhibitory activity on DPP‐IV were within the range of 23.43–128.40 μmol L−1. AQ‐7 had the best activity, with an IC50 value of 23.43 μmol L−1. Enzyme kinetics indicated the presence of various inhibition types (mixed, non‐competitive and competitive). Isothermal titration microcalorimetry showed that the main forces of the binding sites between peptide (GF‐6 or AQ‐7) and DPP‐IV were hydrogen bond, hydrophobic interaction and van der Waals force. The key residues involved in peptide–enzyme interaction were determined by molecular docking. Furthermore, at a concentration of 800 μmol L−1, GF‐6 was found to significantly increase the glucose consumption in insulin‐resistant HepG2 cells (P < 0.05) compared with the model group.CONCLUSIONSacha inchi meal‐derived peptides displayed potent DPP‐IV inhibition activity and could be used in the health food industry and as lead compounds for diabetes therapy. © 2023 Society of Chemical Industry.
The efficacy of translocation as a tool to augment populations of Gambel's quail
Authors: Acevedo Cherie J. , Koprowski John L. , Cavalcant Callie , Harding Larisa , Heffelfinger James R. 
Published: January 2023

AbstractTranslocation is a management strategy that can be used to augment and reestablish populations or increase a species' range by establishing new populations. Gambel's quail (Callipepla gambelii) are the only native upland game birds in many desert areas of the American Southwest. Drought may be a driver in Gambel's quail population declines; however, quail in urban environments may remain abundant because these areas may contain more reliable sources of food, water, and cover. We hypothesized that translocation of urban quail following a wet winter, when resources are plentiful in their native habitat, might allow us to increase the rate at which extant populations are able to recover following drought by capitalizing on the high reproductive capacity of quail. To assess translocation as a management tool for augmentation of populations of Gambel's quail, we translocated 370 quail from 2019 to 2021 to augment 2 sites in the Altar Valley in Arizona, USA: King's Anvil Ranch (KA) and Santa Margarita Ranch (SM). We radiotracked 155 female quail on 2 study areas (KA: n = 77, SM: n = 78) to estimate 200‐day post‐release survival. Release site had the most impact on demographic rates. Quail in KA had higher survival (63.4–70.9%) than quail in SM (19.3–33.1%); however, quail in SM had higher nesting effort and success (nest effort = 63%, nest success = 50%) than quail in KA (nest effort = 33%, nest success: 0%) in the first year. Although this study showed that urban quail can survive and reproduce following translocation, neither site showed both high survival and high reproductive success. Furthermore, although spring call counts indicated augmentation may have had some short‐term benefits due to increased reproductive activity, we are not able to conclude that it increased quail abundance. Given the low annual adult survival rates of Gambel's quail, high spring‐summer survival alone will not be enough to boost wild populations in a measurable way the following year. Therefore, the ability of translocation to augment extant populations may be limited by low and variable reproductive success.