bluuebunny/crossref_metadata_2025_split huggingface dataset:
Energy Expenditure, Body Composition, and Skeletal Muscle Oxidative Capacity in Patients with Myotonic Dystrophy Type 1
Authors: Joosten Isis B.T. , Fuchs Cas J. , Beelen Milou , Plasqui Guy , van Loon Luc J.C. , Faber Catharina G. 
Published: May 2023

Background: Myotonic dystrophy type 1 (DM1) patients are at risk for metabolic abnormalities and commonly experience overweight and obesity. Possibly, weight issues result from lowered resting energy expenditure (EE) and impaired muscle oxidative metabolism. Objectives: This study aims to assess EE, body composition, and muscle oxidative capacity in patients with DM1 compared to age-, sex- and BMI-matched controls. Methods: A prospective case control study was conducted including 15 DM1 patients and 15 matched controls. Participants underwent state-of-the-art methodologies including 24 h whole room calorimetry, doubly labeled water and accelerometer analysis under 15-days of free-living conditions, muscle biopsy, full body magnetic resonance imaging (MRI), dual-energy x-ray absorptiometry (DEXA), computed tomography (CT) upper leg, and cardiopulmonary exercise testing. Results: Fat ratio determined by full body MRI was significantly higher in DM1 patients (56 [49–62] %) compared to healthy controls (44 [37–52] % ; p = 0.027). Resting EE did not differ between groups (1948 [1742–2146] vs (2001 [1853–2425>] kcal/24 h, respectively; p = 0.466). In contrast, total EE was 23% lower in DM1 patients (2162 [1794–2494] vs 2814 [2424–3310] kcal/24 h; p = 0.027). Also, DM1 patients had 63% less steps (3090 [2263–5063] vs 8283 [6855–11485] steps/24 h; p = 0.003) and a significantly lower VO2 peak (22 [17–24] vs 33 [26–39] mL/min/kg; p = 0.003) compared to the healthy controls. Muscle biopsy citrate synthase activity did not differ between groups (15.4 [13.3–20.0] vs 20.1 [16.6–25.8] μM/g/min, respectively; p = 0.449). Conclusions: Resting EE does not differ between DM1 patients and healthy, matched controls when assessed under standardized circumstances. However, under free living conditions, total EE is substantially reduced in DM1 patients due to a lower physical activity level. The sedentary lifestyle of DM1 patients seems responsible for the undesirable changes in body composition and aerobic capacity.
Mainstreaming Interfaith Education
Authors: Salim Arhanuddin 
Published: May 2023

Â Abstract
This paper evaluates interfaith education in Indonesia through a case study of Interfidei's school program in Yogyakarta. Interfaith education is one of Indonesia's most common ways of addressing interfaith tensions. This qualitative research uses a comparative descriptive method with data collection techniques using in-depth interview techniques, observation, and documentation. The research location is in Yogyakarta, observing the implementation of the Interfaith School at the Interfidei Foundation, Yogyakarta. Interfidei school is an excellent interfaith school in Indonesia. The form of interfaith education developed by Interfidei focuses on interfaith community activities and is booming with the interpersonal approach to reduce prejudice between participants. However, interreligious education focusing on interpersonal relations fails to bring about significant inter-religious understanding because it avoids discussing fundamental theological issues and differences. The results showed that theological and philosophical approaches are needed to bring about a profound change in interfaith knowledge in Indonesia rather than the current focus on interpersonal relations.
Abstrak
Tulisan ini mengevaluasi pendidikan lintas agama di Indonesia melalui studi kasus program sekolah Interfidei di Yogyakarta. Pendidikan lintas agama adalah salah satu cara paling umum di Indonesia untuk mengatasi ketegangan antar agama. Penelitian kualitatif ini menggunakan metode deskriptif komparatif dengan teknik pengumpulan data menggunakan teknik wawancara mendalam, observasi, dan dokumentasi. Penelitian dilakukan di Yogyakarta, pada Sekolah Lintas Agama di Yayasan Interfidei. Sekolah Interfidei adalah sekolah unggulan antar-agama di Indonesia. Bentuk pendidikan lintas agama yang dikembangkan oleh Interfidei menitikberatkan pada kegiatan komunitas lintas agama dengan pendekatan interpersonal untuk mengurangi prasangka antar peserta. Namun, pendidikan antar-agama yang menitikberatkan pada relasi interpersonal menghasilkan pemahaman antar-agama yang signifikan karena menghindari pembahasan persoalan dan perbedaan teologis yang mendasar. Hasil penelitian menunjukkan bahwa pendekatan teologis dan filosofis diperlukan untuk membawa perubahan mendalam dalam pengetahuan lintas agama di Indonesia daripada fokus hubungan interpersonal saat ini.
Lebih Baik Sekolah Daripada Main
Authors: Khozin Wahid 
Published: May 2023

Abstract
This research discusses community support for madrasah tsanawiyah (MTs) Al Muhajirin located in the place of final disposal garbage Bantargebang. The community who live around MTs are scavengers whose life is collecting garbage at the Bantargebang TPA. The environment of the madrasa tends to be exploitative and sometimes ignores the norm. The community view of education is straightforward, "It is better for school (children) than to play." Parents feel happy when their children are at school. The parents chose educational institutions at MTs, so their children could understand religion and not be like their parents, who lacked religion. This situation puts MTs Al Muhajirin, which has a vision of upholding Islamic values, still has to run on its own and has yet to receive complete support from its community. This research is qualitative, and critical informants are the foundation's chief, principal, teachers, parents, and students.
Abstrak
Penelitian ini mengkaji masyarakat pendukung Madrasah Tsanawiyah (MTs) Al Muhajirin yang terletak di kawasan Tempat Pembuangan Akhir (TPA) Bantargebang. Letaknya yang demikian, MTs ini dikelilingi tumpukan sampah, rumah-rumah reot dan sangat kumuh. Mereka yang tinggal di sekeliling MTs Al Muhajirin adalah para pemulung yang hidupnya mengais sampah di TPA Bantargebang. Lingkungan MTs sangat diwarnai oleh sebuah kehidupan yang tidak wajar dalam arti bahwa relasi sosial yang berlaku merupakan relasi ekonomis yang cenderung eksploitatif dan terkadang mengabaikan norma. Pandangan masyarakat terhadap pendidikan masih sangat sederhana yaitu â€œLebih baik anak sekolah daripada mainâ€. Pernyataan ini mempunyai maknaÂ cukup luas, diantaranya, orang tua merasa tenang ketika anaknya berada di sekolah. Di sisi lain,Â mereka memilih lembaga pendidikan di MTs dengan alasan agar anak-anak mereka bisa memahami agama dan tidak seperti orang tuanya yang buta agama. Situasi ini, memosisikan MTs Al Muhajirin yang memiliki visi menegakkan nilai-nilai Islam masih harus berjalan sendiri, belum mendapat dukungan yang utuh dari masyarakatnya. Penelitian ini menggunakan metode kualitatif dengan informan ketua yayasan, kepala madrasah, orangtua peserta didik, peserta didik dan guru. Alat pengumpul data yang digunakan adalah panduan waancara, panduan FGD.
Strategi Pengembangan Objek Wisata Pantai Faularan Desa Tuamese Kecamatan Biboki Anleu, Kabupaten Timor Tengah Utara
Authors: Afenpah Oliva , Nalle Frederich Winston , Andari Ismi 
Published: May 2023

Masalah utama dalam penelitian ini adalah kualitas infrastruktur jalan yang belum memadai, kurangnya fasilitas penunjang objek wisata seperti lopo, tempat sampah, kamar mandi/Wc serta tempat duduk disekitaran pantai, minimya promosi objek wisata dan tidak adanya tindak lanjut dari pemerintah daerah maupun pemerintah desa untuk mengembangkan objek wisata. Rumusan masalah dalam penelitian ini adalah bagaimana strategi pengembangan objek wisata Pantai Faularan, Desa Tuamese, Kecamatan Biboki Anleu, Kabupaten TTU. Penelitian ini bertujuan untuk mengetahui strategi pengembangan objek wisata Pantai Faularan, Desa Tuamese, Kecamatan Biboki Anleu, Kabupaten TTU. Penelitian ini di lakukan pada Pantai Faularan, Desa Tuamese, Kecamatan Biboki Anleu, Kabupaten TTU. Data yang digunakan dalam penelitian ini adalah data primer yang diambil menggunakan kuisioner yang telah disesuaikan dengan indikator setiap variabel yakni variabel kekuatan, kelemahan, peluang dan ancaman. Sampel dalam penelitian ini berjumlah 90 responden. Alat analisis yang digunakan dalam penelitian ini adalah analisis SWOT. Hasil penelitian menunjukan bahwa objek wisata pantai Faularan Tuamese memiliki nilai faktor internal ( IFAS) sebesar 3,862 yang terdiri dari kekuatan sebesar 1,712 dan kelemahan sebesar 2,150. Kemudian faktor eksternal (EFAS) sebesar 4,00 yang terdiri dari peluang sebesar 2,056 dan ancaman sebesar 1,944. Hasil analisis SWOT menggunakan diagram cartesius menunjukkan bahwa objek wisata pantai Faulran Tuamese berada pada Kuadran III (Negatif-Positif) dengan faktor internal (kekuatan – kelemahan) sebesar -0,438 dan faktor eksternal (peluang – ancaman) sebesar 0,112, di mana posisi ini menandakan objek wisata pantai Faularan Tuamese yang lemah namun sangat berpeluang. Rekomendasi strategi yang diberikan adalah ubah strategi, artinya instansi terkait dalam pengembangan objek wisata pantai Faularan disarankan untuk mengubah strategi sebelumnya. Sebab, strategi yang lama dikhawatirkan sulit untuk dapat menangkap peluang yang ada sekaligus memperbaiki kinerja organisasi.
PELATIHAN SOFTWARE R UNTUK ANALISIS DESKRIPTIF SEBAGAI UPAYA PENINGKATAN KEMAMPUAN GURU DALAM OLAH DATA
Authors: Juliza Melda , Angreni Puce 
Published: May 2023

Kegiatan pengabdian masyarakat ini dilakukan dengan upaya untuk memperbaharui pengetahuan dan wawasan para guru dalam meningkatkan kemampuan teknologi dimasa sekarang. Terutama dalam hal aplikasi selain Microsoft Office Excel pendukung pembelajaran dan tugas guru, khususnya dalam penyajian data. Oleh karena itu, kegiatan pelatihan pengabdian masyarakat ini difokuskan untuk meningkatkan kemampuan guru memahami konsep statistika deskriptif secara tepat, khususnya dalam penyajian data menggunakan software R. Tujuan diadakan pelatihan ini supaya dewan guru SMK 5 Kaur memiliki kemampuan dalam mengoperasikan aplikasi R dalam analisis deskriptif. Adapun manfaat pelatihan analisis data statistika menggunakan aplikasi R bagi dewan guru diantaranya adalah mengetahui cara menjalankan aplikasi R, memanggil data dari excel pada aplikasi R, dan melakukan analisis deskriptif menggunakan aplikasi R. Metode pelaksanaan kegiatan pengabdian dengan ceramah dan praktek. Kegiatan pelatihan meliputi pemaparan materi dilanjutkan dengan praktek. Harapannya, Hasil kegiatan ini diharapkan bermanfaat bagi dewan guru SMK 5 Kaur, sehingga lebih aktif dan produktif dalam menunjang tugas pokok dan fungsinya.
ANALISIS KUALITAS DAN KUANTITAS UDARA PADA SISTEM VENTILASI TAMBANG BAWAH TANAH KENCANA DI PT. NUSA HALMAHERA MINERALS
Authors: Adam Iksan Muksin , Nurany Nurany , Latif Anas Abdul , Sahetapy George Belly 
Published: May 2023

Dalam metode tambang bawah tanah penting adanya sistem ventilasi yang baik, ventilasi merupakan upaya pengontrolan terhadap kualitas dan kuantitas udara pada aliran udara di penambangan bawah tanah. Pengukuran dilakukan secara kuantitatif di lapangan berupa data Psikometri, luas lubang bukaan, velocity, dan Pressure Vent duct. Kualitas dan kuantitas udara di tambang bawah tanah kencana dikaji dengan memperhitungkan nilai Thermal Work Limit, debit udara yang masuk dan keluar serta kehilangan energi (head loss) pada secondary fan. Berdasarkan hasil pengolahan data diperoleh, ada 7 front yang berada pada zona aklimatisasi yang berada pada rentang nilai 140 â€“ 219 dan 2 front yang berada pada zona buffer yang berada pada rentang nilai 116 â€“ 139, 2 front berada pada zona buffer dikarenakan win speed yang sampai ke face rendah. Hasil pengolahan data debit udara secara kondisi aktual dan simulasi diperoleh udara di jalur exhaust lebih besar dibandingkan dengan udara di jalur fresh air, hal ini dikarenakan adanya kebocoran pada vent door yang membatasi antara jalur fresh air dan exhaust. Hasil pengolahan data pressure Vent duct pada 4 front diperoleh adanya banyak perubahan lintasan dan kebocoran serta jarak motor fan ke face yang jauh secara aktual hal ini menyebabkan udara yang sampai di face juga berkurang, hasil secara aktual dan teori jika dikomparasikan akan mengalami perbedaan karena secara teori jalur Vent duct lurus hasilnya yaitu pada teori di front KNF SB14B SILL dengan jarak 400 m dan pada kondisi aktual adalah 309 m, udara yang seharusnya sampai di face secara teori adalah 35.21 m3/s namun pada kondisi aktual adalah 15.05 m3/s. pada front K1 SB07B UC01 Teori 400 m dan 35.21 m3/s, aktual 320 m dan 13.66 m3/s, front KL SB10A UC03 Teori 400 m dan 26.72 m3/s, aktual 382 m dan 13.66 m3/sÂ dan front K2 SB09H UC01 Teori 350 m dan 28.62 m3/s, aktual 331 m dan 12.16 m3/s.Kata kunci: Ventilasi, Psikometri, Debit Udara, Vent duct, Head Loss Â Â
Effects of E-health-based interventions on glycemic control for patients with type 2 diabetes: a Bayesian network meta-analysis
Authors: Zhang Xiaoyue , Zhang Lanchao , Lin Yuxin , Liu Yihua , Yang Xiaochen , Cao Wangnan , Ji Ying , Chang Chun 
Published: May 2023

The high disease burden of type 2 diabetes seriously affects the quality of life of patients, and with the deep integration of the Internet and healthcare, the application of electronic tools and information technology to has become a trend for disease management. The aim of this study was to evaluate the effectiveness of different forms and durations of E-health interventions in achieving glycemic control in type 2 diabetes patients. PubMed, Embase, Cochrane, and Clinical Trials.gov were searched for randomized controlled trials reporting different forms of E-health intervention for glycemic control in type 2 diabetes patients, including comprehensive measures (CM), smartphone applications (SA), phone calls (PC), short message service (SMS), websites (W), wearable devices (WD), and usual care. The inclusion criteria were as follows: (1) adults (age≥18) with type 2 diabetes mellitus; (2) intervention period ≥1 month; (3) outcome HbA1c (%); and (4) randomized control of E-health based approaches. Cochrane tools were used to assess the risk of bias. R 4.1.2 was used to conduct the Bayesian network meta-analysis. A total of 88 studies with 13,972 type 2 diabetes patients were included. Compared to the usual care group, the SMS-based intervention was superior in reducing HbA1c levels (mean difference (MD)-0.56, 95% confidence interval (CI): -0.82 to -0.31), followed by SA (MD-0.45, 95% CI: -0.61 to -0.30), CM (MD-0.41, 95% CI: -0.57 to -0.25), W (MD-0.39, 95% CI: -0.60 to -0.18) and PC (MD-0.32, 95% CI: -0.50 to -0.14) (p &lt; 0.05). Subgroup analysis revealed that intervention durations of ≤6 months were most effective. All type of E-health based approaches can improve glycemic control in patients with type 2 diabetes. SMS is a high-frequency, low-barrier technology that achieves the best effect in lowering HbA1c, with ≤6 months being the optimal intervention duration.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42022299896.
Maternal elevated inflammation impairs placental fatty acids β-oxidation in women with gestational diabetes mellitus
Authors: Visiedo Francisco , Vázquez-Fonseca Luis , Ábalos-Martínez Jessica , Broullón-Molanes J. Román , Quintero-Prado Rocío , Mateos Rosa María , Bugatto Fernando 
Published: May 2023

IntroductionAn adverse proinflammatory milieu contributes to abnormal cellular energy metabolism response. Gestational diabetes mellitus (GDM) is closely related to an altered maternal inflammatory status. However, its role on lipid metabolism regulation in human placenta has not yet been assessed. The aim of this study was to examine the impact of maternal circulating inflammatory mediators ([TNF]-α, [IL]-6, and Leptin) on placental fatty acid metabolism in GDM pregnancies.MethodsFasting maternal blood and placental tissues were collected at term deliveries from 37 pregnant women (17 control and 20 GDM). Molecular approach techniques as radiolabeled lipid tracers, ELISAs, immunohistochemistry and multianalyte immunoassay quantitative analysis, were used to quantify serum inflammatory factors’ levels, to measure lipid metabolic parameters in placental villous samples (mitochondrial fatty acid oxidation [FAO] rate and lipid content [Triglycerides]), and to analyze their possible relationships. The effect of potential candidate cytokines on fatty acid metabolism in ex vivo placental explants culture following C-section a term was also examined.ResultsMaternal serum IL-6, TNF-α and leptin levels were significantly increased in GDM patients compared with control pregnant women (9,9±4,5 vs. 3,00±1,7; 4,5±2,8 vs. 2,1±1,3; and 10026,7±5628,8 vs. 5360,2±2499,9 pg/ml, respectively). Placental FAO capacity was significantly diminished (~30%; p&lt;0.01), whereas triglyceride levels were three-fold higher (p&lt;0.01) in full-term GDM placentas. Uniquely the maternal IL-6 levels showed an inverse and positive correlation with the ability to oxidize fatty acids and triglyceride amount in placenta, respectively (r= -0,602, p=0.005; r= 0,707, p=0.001). Additionally, an inverse correlation between placental FAO and triglycerides was also found (r=-0.683; p=0.001). Interestingly, we ex vivo demonstrated by using placental explant cultures that a prolonged exposure with IL-6 (10 ng/mL) resulted in a decline in the fatty acid oxidation rate (~25%; p=0.001), along to acute increase (2-fold times) in triglycerides accumulation (p=0.001), and in lipid neutral and lipid droplets deposits.ConclusionsEnhanced maternal proinflammatory cytokines levels (essentially IL-6) is closely associated with an altered placental fatty acid metabolism in pregnancies with GDM, which may interfere with adequate delivery of maternal fat across the placenta to the fetus.
Evaluation of triple negative breast cancer with heterogeneous immune infiltration
Authors: Quintana Ángela , Arenas Enrique Javier , Bernadó Cristina , Navarro José Fernández , González Jonatan , Esteve-Codina Anna , Moliné Teresa , Marti Merce , Curigliano Giuseppe , Schmid Peter , Peg Vicente , Arribas Joaquín , Cortés Javier 
Published: May 2023

IntroductionTumor infiltrating lymphocytes (TILs) are known to be a prognostic and predictive biomarker in breast cancer, particularly in triple negative breast cancer (TNBC) patients. International guidelines have been proposed to evaluate them in the clinical setting as a continuous variable, without a clear defined cut-off. However, there are scenarios where the immune infiltration is heterogeneous that some areas of the patient’s tumour have high numbers of TILs while other areas completely lack them. This spontaneous presentation of a heterogeneous immune infiltration could be a great opportunity to study why some tumours present TILs at diagnosis but others do not, while eliminating inter patient’s differences.MethodsIn this study, we have identified five TNBC patients that showed great TIL heterogeneity, with areas of low (≤5%) and high (≥50%) numbers of TILs in their surgical specimens. To evaluate immune infiltration heterogeneity, we performed and analyzed bulk RNA-sequencing in three independent triplicates from the high and low TIL areas of each patient.ResultsGene expression was homogeneous within the triplicates in each area but was remarkable different between TILs regions. These differences were not only due to the presence of TILs as there were other non-inflammatory genes and pathways differentially expressed between the two areas.DiscussionThis highlights the importance of intratumour heterogeneity driving the immune infiltration, and not patient’s characteristics like the HLA phenotype, germline DNA or immune repertoire.
The shed P2X7 receptor is an index of adverse clinical outcome in COVID-19 patients
Authors: Vultaggio-Poma Valentina , Sanz Juana Maria , Amico Andrea , Violi Alessandra , Ghisellini Sara , Pizzicotti Stefano , Passaro Angelina , Papi Alberto , Libanore Marco , Di Virgilio Francesco , Giuliani Anna Lisa 
Published: May 2023

IntroductionThe pathophysiology of the Corona Virus Disease 2019 (COVID-19) is incompletely known. A robust inflammatory response caused by viral replication is a main cause of the acute lung and multiorgan injury observed in critical patients. Inflammasomes are likely players in COVID-19 pathogenesis. The P2X7 receptor (P2X7R), a plasma membrane ATP-gated ion channel, is a main activator of the NLRP3 inflammasome, of the ensuing release of inflammatory cytokines and of cell death by pyroptosis. The P2X7R has been implicated in COVID-19-dependent hyperinflammation and in the associated multiorgan damage. Shed P2X7R (sP2X7R) and shed NLRP3 (sNLRP3) have been detected in plasma and other body fluids, especially during infection and inflammation.MethodsBlood samples from 96 patients with confirmed SARS-CoV-2 infection with various degrees of disease severity were tested at the time of diagnosis at hospital admission. Standard haematological parameters and IL-6, IL-10, IL-1β, sP2X7R and sNLRP3 levels were measured, compared to reference values, statistically validated, and correlated to clinical outcome. ResultsMost COVID-19 patients included in this study had lymphopenia, eosinopenia, neutrophilia, increased inflammatory and coagulation indexes, and augmented sNLRP3, IL-6 and IL-10 levels. Blood concentration of sP2X7R was also increased, and significantly positively correlated with lymphopenia, procalcitonin (PCT), IL-10, and alanine transaminase (ALT). Patients with increased sP2X7R levels at diagnosis also showed fever and respiratory symptoms, were more often transferred to Pneumology division, required mechanical ventilation, and had a higher likelihood to die during hospitalization. ConclusionBlood sP2X7R was elevated in the early phases of COVID-19 and predicted an adverse clinical outcome. It is suggested that sP2X7R might be a useful marker of disease progression.