bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mechanism of copper deficiency on oxidative stress in liver of mice
Authors: Pan Zhiying , Deng Chengfeng , Shui Lian , Yin Heng , Liu Bing 
Published: April 2023

Abstract
Copper (Cu) is an essential metal required for many physiological processes and biological reactions. Liver is the main organ of metabolism of Cu, and is also the site where synthesis of some metalloproteins. The purpose of this study is to explore the effects of Cu deficiency on the liver, and to evaluate the changes in liver oxidative stress levels to reveal its possible impact mechanisms. Mice were feed to a nutritional Cu-deficiency diet from weaning and injected with copper sulphate (CuSO4) intraperitoneally to correct Cu deficiency. Cu deficiency resulted in reduced liver index, liver histological alteration and oxidative stress, decreased the contents of Cu and ALB, elevated ALT and AST concentrations in serum together with decreased mRNA and protein expressions of Nrf2 pathway related molecules (Nrf2, HO-1, NQO1), increased mRNA and protein expressions of Keap1. However, the supplement of CuSO4 significantly ameliorated the changes mentioned above. Our results indicate that Cu deficiency can cause hepatic damage in mice is associated with the activation of oxidative stress and inhibition of Nrf2 pathway.
Global Trends in Research of Coronary Microvascular Dysfunction Over Past Two Decades: A Bibliometric Analysis
Authors: Tan Yu , Yu Yanqiao , Luo Jinwen , Zhao Xiaohan , Liu Min , Li Min , Liu Wei , Ma Xiaojuan , Shi Dazhuo 
Published: April 2023

Abstract
After a successful percutaneous coronary intervention, a large number of patients with acute coronary syndrome are still suffering from coronary microvascular dysfunction (CMD), which has become a global health threat. Over the past two decades, CMD-related studies have increased rapidly. This field, however, lacks bibliometric studies. In this research, we used bibliometric analysis to summarize hotspots and trends in scientific and clinical research on CMD. Web of Science Core Collection database was used to collect CMD-related research. Each study was analyzed bibliometrically and visually. CiteSpace and VOSviewer software were performed to generate knowledge maps. Over the past two decades, research on CMD has exploded. Scholars have concentrated on the long-term effects of CMD on a variety of cardiovascular disorders with poor prognoses, such as acute myocardial infarction and heart failure. In the meantime, despite the availability of many invasive and non-invasive tests, the anticipatory detection of CMD during the hypoperfusion phase of myocardial ischemia may be the windfall of future research.
Early research trends on ChatGPT: a review based on Altmetrics and science mapping analysis
Authors: Raman Raghu , lathabhai hiran , Diwakar Shyam , Nedungadi Prema 
Published: April 2023

Abstract
In the three months following its launch in November 2022, ChatGPT, the LLM bot employing deep learning algorithms to generate human-like responses, has been the subject of numerous research articles (n=385). Identifying early attention to this research is highly intriguing. As citations for these publications may take time to accumulate, our study focused on examining the early attention of ChatGPT research using the Altmetric Attention Score (AAS), a composite attention score developed by Digital Science. Our findings from the total set of publications and the top publications according to the highest AAS scores reveal the following trends: (i) The United States, Japan, and the United Kingdom are the top countries that published most of the top research articles related to ChatGPT. (ii) The most frequently mentioned source titles include journals like Nature, Science, and preprint sources like medRxiv and arXiv. (iii) Among the fields of research (FoR) to which ChatGPT publications align, 'information and computing sciences' and 'biomedical and clinical sciences' received the highest mentions. (iv) Five major clusters were identified in the network formed by the interlinkage of FoRs. (v) The most prominent themes discussed in top articles within these five clusters include ChatGPT usage in medical writing and determining ChatGPT's role in scientific publishing. (vi) Scientists are found to be the major user category demonstrating the highest level of interest in ChatGPT research. By capturing these early trends in both ChatGPT research and the early attention to this research, our work offers valuable insights for ChatGPT enthusiasts, researchers, and policymakers in fields such as biomedical sciences, scientific publishing, and many others.
Identifying different patterns of emotional dysregulation in adult ADHD
Authors: Martz Emilie , Weiner Luisa , Weibel Sébastien 
Published: April 2023

Abstract
Background: Emotional dysregulation (ED) is a core intrinsic feature of adult presenting Attention Deficit Hyperactivity Disorder (ADHD). However, the clinical expressions of ED are diverse and several questionnaires have been used to measure ED in adults with ADHD. Thus, to date, the characteristics of ED in adult ADHD remain poorly defined. The objective of this study is to identify the different patterns of ED in adults with ADHD.
Methods: A large sample of 460 newly diagnosed adults with ADHD were recruited. Patients
completed a total of 20 self-reported questionnaires. Measures consisted in the several facets of ED, but also other clinical features of adult ADHD such as racing thoughts. A factor analysis with the principal component extraction method was performed to define the symptomatic clusters. A mono-dimensional clustering was then conducted to assess whether participants presented or not with each symptomatic cluster.
Results: The factor analysis yielded a 5 factor-solution, including “emotional instability”, “impulsivity”, “overactivation”, “inattention/disorganization”, “sleep problems”. ED was part of two out five clusters and concerned 67.52% of our sample. Among those patients, the combined ADHD presentation was the most prevalent. Emotional instability and impulsivity were significantly predicted by childhood maltreatment. The ED and the “sleep problems” factors contributed significantly to the patients’ functional impairment.
Conclusions: ED in ADHD is characterized along emotional instability and emotional impulsivity and significantly contribute to the functional impairment. However, beyond impairing symptoms, adult ADHD may also be characterized by functional strengths such as creativity.
Vectorial bent functions and Linear Codes from Quadratic Forms
Authors: Xie Xianhong , Ouyang Yi , Mao Ming 
Published: April 2023

Abstract
In this paper, we study the vectorial bentness of an arbitrary quadratic form and construct two classes of linear codes of few weights from the quadratic forms. Let $q$ be a prime power, $m$ be a positive integer and $Q:\F_{q^m}\rightarrow\F_q$ be a quadratic form. We first show that $Q$ is a vectorial bent function if and only if $Q$ is non-degenerate and $(q+1)m$ is even (i.e. either $q$ is odd or $m$ is even). Furthermore, if $2\mid (q+1)m$ and $Q(x)= \sum\limits_{i=0}^{m-1} \Tr_{q^m/q}(a_i x^{q^i+1})\ (a_i\neq 0)$, we show that $Q$ is vectorial bent if and only if the associated additive polynomial $L_Q(x)=\sum_i (a_i + a_{m-i}^{q^{i}}) x^{q^i}$ is a permutation polynomial over $\F_{q^m}$. If there is only one $a_i\neq 0$, we recover the constructions of Sidelnikov, Dembowski-Ostrom and Kasami of quadratic vectorial bent functions. We then construct two classes of linear codes $\C'_Q$ and $\C_Q$ over $\F_q$ from $Q$ and completely determine the weight distributions of our codes, showing that they are two-, three- or four-weight codes and contain optimal codes satisfying the Griesmer and Singleton bounds.
2010 Mathematics Subject Classification. 94B05, 15A63, 94A60.
Distributed Backward Pumped Raman Amplifier Gain Enhancement: New Approaches
Authors: Mustafa Fathy M. , Kholidy Hisham A. , Sayed Ahmed F. , Aly Moustafa H. , Elmisery F. A. 
Published: April 2023

Abstract
The backward Raman amplifier (RA) can considered as one of the best solutions for optical communication, especially in Wavelength Division Multiplexing (WDM) technology. They reduce the nonlinear effects, have low noise figure and a wide frequency range. The work in this paper aims to reduce the attenuation of optical signal due to its propagation optical fiber and increase both amplifier gain and output signal power. Two backward Raman models are proposed. Proposal one model consists of two cascaded RAs and the other (proposal two) consists of three cascaded RAs. Three backward pump power levels 200, 400, and 600 mW are used to simulate the models with the three types of fibers: single-mode fiber (SMF), Truewave, and Freelight, at an amplifier length of 100 km. Proposal two achieves a maximum gain of 31 dB at 600 mW pump power 600 mW using Truewave optical fiber, with 27.7 dBm maximum output signal power. This proposal is evaluated showing 11.15% gain enhancement and 200 mW saved power when compared to previously published work.
Plasmodium falciparum malaria exposure and carriage associate with reduced γδ T-cells and NK cell responses to infected red blood cells in vitro
Authors: Kouriba Bourèma , Daou Modibo , Arama Charles , Ouédraogo Nicolas , Niaré Karamoko , Keita Yamoussa , Sissoko Sibiri , Ouologuem Boucary , Arama Seydou , Doumbo Ogobara , Sauerwein Robert , Scholzen Anja 
Published: April 2023

Abstract
Background
Innate immune cells including γδ T-cells and NK cells are directly activated by Plasmodium falciparum parasites and contribute to the control of parasitaemia. The aim of this study was to determine whether a history of parasite exposure and/or carriage affect innate immune cell responses in vitro to P. falciparum infected red blood cells (PfRBC).
Methods
Peripheral blood mononuclear cells were collected from 61 Malian children aged 5 to 15 years at the start of the transmission season, and 10 malaria-naïve Dutch adults. Parasite carriage at the start of the transmission season was assessed by PCR and microscopy for Malian children. Peripheral blood mononuclear cells were stimulated with PfRBC to assess cytokine production and degranulation of innate lymphocytes (γδ T-cells, CD3+CD56+ cells and NK cells) by flow cytometry.
Results
Granzyme B production in response to PfRBC was observed by all three innate cell subsets in Malian children, as were IFNγ production by γδ T-cells and NK cells and γδ T-cell degranulation. However, both IFNγ production and degranulation by γδ T-cells, CD3+CD56+ cells and NK cells were significantly lower compared to malaria-naïve Dutch adults. Moreover, children with ongoing P. falciparuminfection showed significantly reduced PfRBC-specific IFNγ production and degranulation by γδ T-cells and NK cells as compared with those with undetectable parasitaemia by PCR and microscopy. Reduced degranulation responses by γδ T-cells and NK cells were already observed for children with submicroscopic parasitaemia as compared to those with negative PCR.
Conclusions
Malian children show reduced P. falciparum-specific innate IFNγ production and cytotoxic degranulation, which were further negatively impacted by ongoing infections of microscopic but also submicroscopic parasitaemia.
Post-operative segmental cerebral venous sinus thrombosis: risk factors, clinical implications and therapeutic considerations.
Authors: Sturiale Carmelo Lucio , Auricchio Anna Maria , Valente Iacopo , Vacca Alessandro , Pennisi Giovanni , Ciaffi Gabriele , Albanese Alessio , Olivi Alessandro , Trevisi Gianluca 
Published: April 2023

Abstract
Background
Cerebral venous sinus thromboses (CVSTs) are rare complications of neurosurgical interventions and their management remains controversial as most of cases appears clinically silent.
Here, we analyzed our institutional series of patients with CVSTs evaluating clinical and neuroradiological characteristics, risk factors, and outcome.
Materials and methods
From the analysis of our institutional PACS, we collected a total of 59 patients showing postoperative CVSTs after supratentorial or infratentorial craniotomies. For every patient, we collected demographics and relevant clinical and laboratory data. Details on thrombosis trend were retrieved and compared along the serial radiological assessment.
Results
A supratentorial craniotomy was performed in 57.6% of cases, an infratentorial in 37.3%, while the remaining were a single cases of trans-sphenoidal and neck surgery (1.7%, respectively). A sinus infiltration was present in almost a quarter of patients, and in 52.5% of cases the thrombosed sinus was exposed during the craniotomy.
Radiological signs of CVST were evident in 32.2% of patients, but only 8.5% of them developed a hemorrhagic infarct. CVST-related symptoms were complained by 13 patients (22%), but these were minor symptoms in about 90%, and only 10% experienced hemiparesis or impaired consciousness. The majority of patients (78%) remained completely asymptomatic along the follow-up. Risk factors for symptoms occurrence were interruption of preoperative anticoagulants, infratentorial sinuses involvement and evidence of vasogenic edema and venous infarction. Overall, a good outcome was observed in about 88% of patients at follow-up.
Conclusions
CVST is a complication of surgical approaches in proximity of dural venous sinuses. CVST usually does not show progression and courses uneventfully in the vast majority of cases. The systematic use of post-operative anticoagulants seems to not significantly influence its clinical and radiological outcome.
Spherical Derivatives and Normal Functions
Authors: Wei Dongmei , Xu Yan 
Published: April 2023

Abstract
Note: Please see pdf for full abstract with equations.
Let $k$ be a positive integer and $C>0$ an constant, and let $\varphi:[0,1)\to (0,\infty)$ be smoothly increasing. A meromorphic function $f$ in the unit disk is called a $\varphi$-normal function if $\sup_{z\in \Delta}\frac{f^{\#}(z)}{\varphi(|z|)}<\infty$. In this paper, we prove that $f$ is a $\varphi$-normal function if $|f^{(k)}(z)|/(\varphi(|z|)^{k}(1+|f(z)|^{k+1}))\geq C$ ($z\in \Delta)$. Also, the similar results for normal functions and $\alpha$-normal functions are given.
2000Mathematics subject classification:30D45
Voltammetric Study and Kinetic Stability of Nitro Anion Radical in Aqueous Media of Two New Sulfonylhydrazone Derivatives with Potential Anti-Chagas Activity
Authors: Almeida Lígia Scandoglieri , Chiavassa Luísa Donatto , Brito Charles Lima , Gatti Fernando Moura , Trossini Gustavo Henrique Goulart , La-Scalea Mauro Aquiles 
Published: April 2023

Abstract
Two new sulfonylhydrazone derivatives, analogues of nitrofurazone, with potentially antichagasic biological activity were studied by cyclic voltammetry, having glassy carbon as working electrode, in aqueous media aiming at a better understanding of their redox mechanism that can be related to the biological action, being classically characterized by charge transfer processes. In an acidic medium, an irreversible cathodic peak corresponding to the formation of hydroxylamine derivative was observed, being linearly displaced with the decrease in the acidity of the medium to more negative potential values. In alkaline medium, the reduction was independent of the pH, registering the formation of the reversible \(\text{R-N}{\text{O}}_{2}/\text{R-N}{\text{O}}_{2}^{-}\) couple. The half-life of the nitro-anion radical was experimentally estimated and corroborated by simulation with Digisim.
Effect of fertilization and container size on the quality of “Sangre de Drago” (Croton urucurana Baill.) seedlings in a plug + 1 production system.
Authors: Martin Mariana , Castro Damian César , Gabriel Paola Marisel , Micheloud Norma Guadalupe , Álvarez Norma Hortensia , Buyatti Marcela Alejandra 
Published: April 2023

Abstract
“Sangre de Drago” (Croton urucurana Baill.) is a native tree of South America with high value for urban afforestation or the restoration of riparian forests. This study aimed to evaluate the effect of container size and fertilization on the quality of seedlings produced in a plug+1 system. In the establishment phase, the impact of container size (110 mL or 250 mL) and fertilization (with or without) on seedling quality were evaluated before transplanting into bigger containers. In the rapid growth phase, the effect of container size (1 L, 1.5 L, and 3.5 L) on survival and seedling quality was evaluated. At the end of each phase, seedling quality was evaluated through morphological and physiological attributes. Data were analyzed through linear models, generalized linear models, and nonlinear regressions. In the establishment phase, seedlings grown in 250 mL containers with fertilization showed the best performance in morphological and physiological variables and the Dickson quality index. In the rapid growth phase, seedlings grown in 3.5 L containers showed the highest values in total height, stem diameter, total dry weight, Dickson quality index, and the lowest mortality at the end of the experiment. We recommended 250 mL containers with fertilization in the establishment phase until the seedling can be lifted with its intact root ball. We then transplant it into 3.5 L containers for the rapid growth and hardening phases until out-planting.
Exact and approximate solutions of Dirac-Morse problem in curved space-time
Authors: de Oliveira M. D. , Schmidt Alexandre G. M. 
Published: April 2023

Abstract
In this work, we analyze the Dirac-Morse problem with spin and pseudo-spin symmetries in deformed nuclei. So, we consider the Dirac equation with the scalar U (r) and vector V (r) Morse-type potentials and tensor Hellmann-type potential in curved space-time whose line element is of type ds2 = (1 + α2 U (r))2 (dt2 − dr2 )− r2 dθ2 − r2 sin2θdφ2 . From the effective tensor potential Aeff(r) = λ/r + α2 λU(r)/r + A(r), that contain terms of spin-orbit coupling, line element and electromagnetic field, we analyze dirac’s spinor in two ways: (i) in the first, we solve the problem approximately considering A ef f (r) not null; (ii) in the second analysis, we obtain exact solutions of radial spinor and eigenenergies considering Aeff(r) = 0. In both cases, we consider two types of coupling of vector and scalar potentials, with spin symmetry for V (r) = U (r) and pseudo-spin symmetry for V (r) = −U (r). We analyzed the effect of coupling the electromagnetic field with the curvature of space in eigenenergies and radial spinor.
Impact of free vibration on the T-beam deck slab bridge
Authors: Pathak Shubham , Nallasivam K 
Published: April 2023

Abstract
Due to its simplicity in design, construction, and upkeep, the T-beam bridge is the most popular and widely used type of bridge. When it comes to establishing connectivity over both short and long distances, this kind of bridge is more widely used. The mechanisms of vibration resonance for a T-beam deck slab bridge subjected to a moving load series are being probed. the purpose of this article is to calculate the natural frequencies and mode shapes of the Bridge under a variety of cross-sections, material qualities, and support situations. Using the finite element method, this paper attempts to compare the natural frequencies caused by free vibration in a girder and slab and a full-structure T-beam Deck Slab bridge. In finite element software like ANSYS, the bridge is analysed as a three-dimensional model. The natural frequencies and mode shapes of the model would give us the minimum time period and maximum frequency of the bridge on ANSYS software.
The relationships between novel biomarkers Lp-PLA2 and CTRP-3 and MACCE in patients with type 2 diabetes mellitus aged 40-65 years: a retrospective cohort study
Authors: Chen Yanhong , Wang Shixin , Li Jian , Fu Yu , Chen Pengsheng , Zhang Jiao , Sun Li , Zhang Rui , Li Xiaoli , Liu Lingling 
Published: April 2023

Abstract
Background: Adverse cardiovascular and cerebrovascular events (MACCE) has been confirmed as one of the major and severe complications in type 2 diabetes mellitus (T2DM) patients aged 40-65 years, and it is also reported as one of the major causes of death in T2DM patients. Accordingly, the biological markers of MACCE in T2DM patients aged 40-65 years should be found urgently.
Methods: The retrospective cohort study comprised 979 individuals of T2DM aged 40-65 years. To be specific, 116 subjects developed MACCE during the follow up. The clinical examination and the measurement of blood laboratory parameters were performed. Univariate and multivariate factors were adopted to analyze the correlation between Lp-PLA2, CTRP-3 and MACCE in T2DM patients aged 40-65 years. The diagnostic efficacy of the respective index was analyzed using receiver operating characteristic (ROC) curve and area under curve (AUC).
Results: After a median 84 months follow-up [42, (32-54)], the levels of new inflammatory factors Lp-PLA2, CTRP-3 and other traditional index of blood lipids such as LDL-C and ApoB were abnormally expressed in MACCE patients of the positive group of T2DM patients aged 40-65 years. Age-adjusted Cox regression analysis showed that Lp-PLA2 (HR=1.008, 95% confidence interval (CI): 1.006-1.009, P < 0.01) and CTRP-3 (HR=0.943, 95% CI: 0.933-0.954, P < 0.001) were independently correlated with occurrence of MACCE. ROC curve analysis showed that Lp-PLA2 and CTRP-3 could strongly predict the occurrence of MACCE (area under ROC (AUC)= 0.81, 95% CI: 0.77-0.85, P < 0.001) (AUC=0.91, 95% CI: 0.89-0.93, P < 0.001). Combined Lp-PLA2 with CTRP-3 can predict the occurrence of MACCE well (AUC=0.94, 95% CI: 0.93- 0.96, P < 0.001).
Conclusions: The serum levels of Lp-PLA2 and CTRP-3 were abnormally expressed in MACCE patients of T2DM patients aged 40-65 years, and both of them were correlated with the occurrence of MACCE. The combined detection of Lp-PLA2 and CTRP-3 could improve the diagnostic efficacy of MACCE in T2DM patients aged 40-65 years.
Quantifying Acetylene Mole Fraction in Rich Flat Laminar Premixed C2H4/Air Flames
Authors: Zhao Wanxia , Alwahabi Zeyad , Dally Bassam 
Published: April 2023

Abstract
Mid-infrared laser polarization spectroscopy (IRPS) has been applied to measure the mole fraction of acetylene in rich premixed laminar C2H4/Air flat flames at equivalence ratios (Φ) of 1.7, 2.1, and 2.3, and under atmospheric pressure. The detection was conducted by probing the ro-vibrational P(19) transition at ~ 3.1 µm. The total collisional broadening coefficient of C2H2 was approximately 0.074 cm− 1atm− 1 and varied within a range of 0.5% under different flame conditions, which made the effect of linewidth not obvious in the CH4/air flame. The calculated mole fraction of C2H2, using the Chemkin model, at Φ = 1.3 and 1.5 was used to calibrate the recorded IRPS signal intensities at different Height Above Burner (HAB). A single scaling factor was then used to quantify the measured C2H2 at highly sooting conditions, Φ = 1.7, 2.1, and 2.3, with a Limit of Detection (LoD) of 35 ± 5 ppm. The first observed C2H2 mole fraction appeared at HAB of 3 mm and measured as 2003 ppm, 2217 ppm, and 2495 ppm, for Φ = 1.7, 2.1, and 2.3, respectively. The mole fraction increased as the HAB increased to reach the maximum value of 2296 ppm, 2807 ppm, and 3478 ppm, for Φ = 1.7, 2.1, and 2.3, respectively, up to HAB of 5 mm. It was observed that the C2H2 mole fraction reaches a plateau region at HAB of ~ 8 mm. The production of C2H2 has been observed to be subject to a critical gas temperature of 1400 ± 30 K. The critical soot inception temperature, where the first incepted soot particles are observed, is the same as the gas temperature where \({\chi }_{{{C}_{2}H}_{2}}^{max}\) was detected, namely at 1500 ± 30 K. These measurements and calibration procedure demonstrate a plausible technique to probe other flames and to better understand soot inception and its correlation with C2H2.