bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universality and language specificity of brain reading networks: A developmental perspective
Authors: Zhang Jia. , Chen Jie. , Ding Guosheng. 
Published: March 2023

AbstractThe development of reading networks across different languages and cultures provides an important window to address gene‐culture interactions in brain functionality development. Previous meta‐analyses have explored the neural correlates of reading in different languages with diverse orthographic transparencies. However, it remains unknown whether the neural topographic relationship of different languages varies when taking development into account. To address this issue, we conducted meta‐analyses of neuroimaging studies with approaches of activation likelihood estimation and seed‐based effect size mapping and focused on two highly contrasting languages, Chinese and English. The meta‐analyses covered 61 studies of Chinese reading and 64 studies of English reading by native speakers. The brain reading networks of child and adult readers were further separately analyzed and compared to explore the developmental effects. The results revealed that the commonalities and differences in reading networks for Chinese and English were inconsistent between children and adults. In addition, the reading networks converged with development, and the effects of writing systems on brain function organizations were more salient in the initial stages of reading. An interesting finding was that the left inferior parietal lobule demonstrated increased effect sizes in adults compared with children in both Chinese and English reading, indicating a common developmental feature of reading mechanisms across the two languages. These findings provide new insights into the functional evolution and cultural modulation of brain reading networks.Research Highlights
Meta‐analyses with approaches of activation likelihood estimation and seed‐based effect size mapping were performed to evaluate the developmental characteristics of brain reading networks.
The engagement of universal and language‐specific reading networks was different between children and adults, and the reading networks converged with increased reading experience.
Overall the middle/inferior occipital and inferior/middle frontal gyrus were specific to Chinese and the middle temporal, right inferior frontal gyrus were specific to English.
The left inferior parietal lobule was engaged more in adults than children in Chinese and English reading, demonstrating a common developmental feature of reading mechanisms.
Impact of novel glucose‐lowering therapies on physical function in people with type 2 diabetes: A systematic review and meta‐analysis of randomised placebo‐controlled trials
Authors: Ahmad Ehtasham , Arsenyadis Franciskos , Almaqhawi Abdullah , Barker Mary , Jobanputra Rishi , Sargeant Jack A. , Webb David R. , Yates Thomas , Davies Melanie J. 
Published: March 2023

AbstractAimsWe investigated evidence from randomised, placebo‐controlled trials of novel glucose‐lowering therapies; sodium‐glucose co‐transporter‐2 inhibitors (SGLT2i), dipeptidyl peptidase‐4 inhibitors (DPP4i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RA), on physical function in people with type 2 diabetes (T2D).MethodsPubMed, Medline, Embase and Cochrane library were searched from 1 April 2005 to 20 January 2022. The primary outcome was change in physical function in groups receiving a novel glucose‐lowering therapy versus placebo at the trial end‐point.ResultsEleven studies met our criteria including nine for GLP‐1RA and one each for SGLT2i and DPP4i. Eight studies included a self‐reported measure of physical function, seven with GLP‐1RA. Pooled meta‐analysis showed an improvement of 0.12 (0.07, 017) points in favour of novel glucose‐lowering therapies, mainly GLP‐1RA. These findings were consistent when assessed individually for commonly used subjective assessments of physical function; namely the Short‐Form 36 item‐questionnaire (SF‐36; all investigating GLP‐1RA) and the Impact of Weight on Quality of Life‐Lite (IWQOL‐LITE; all, except one, exploring GLP‐1RA) with estimated treatment differences (ETDs) of 0.86 (0.28, 1.45) and 3.72 (2.30, 5.15) respectively in favour of novel GLTs. For objective measures of physical function (VO2max and 6‐minute walk test (6MWT)) no significant between‐group differences between the intervention and the placebo were found.ConclusionsGLP‐1RAs showed improvements in self‐reported outcomes of physical function. However, there is limited evidence to draw definitive conclusions especially because of lack of studies exploring the impact of SGLT2i and DPP4i on physical function. There is a need for dedicated trials to establish the association between novel agents and physical function.
Tooth autotransplantation: An umbrella review
Authors: Tan Bing Liang , Tong Huei Jinn , Narashimhan Srinivasan , Banihani Alaa , Nazzal Hani , Duggal Mandeep Singh 
Published: March 2023

AbstractTooth autotransplantation is a versatile procedure with several clinical applications among patients across different age groups. The success of this procedure depends on multiple factors. Despite the wealth of studies available, no single primary study or systematic review is able to report on every factor affecting the outcomes of autotransplantation. The aims of this umbrella review were to evaluate treatment‐related and patient‐related outcomes of autotransplantation and to assess the pre‐, peri‐ or post‐operative factors that could affect these. An umbrella review was conducted according to the PRISMA statement. A literature search of five databases was performed up to 25 September 2022. Systematic Reviews (SR) with and without meta‐analysis evaluating autotransplantation were included. Calibration among reviewers was carried out prior to study selection, data extraction and Risk of Bias (RoB) assessment. Study overlap was calculated using corrected covered area. Meta‐meta‐analysis (MMA) was performed for suitable SRs. The AMSTAR 2 critical appraisal tool was used to evaluate the quality of evidence. Seventeen SRs met the inclusion criteria. Only two SRs were suitable for conduct of MMA on autotransplantation of open apex teeth. The 5‐year and 10‐year survival rates were >95%. A narrative summary on factors that could affect autotransplantation outcomes and comparisons of autotransplantation to other treatment options were reported. Five SRs were rated as ‘low quality’ and 12 SRs were rated as ‘critically low quality’ in the AMSTAR 2 RoB assessment. In order to facilitate a more homogenous pool of data for subsequent meta‐analysis, an Autotransplantation Outcome Index was also proposed to standardise the definition of outcomes. Autotransplantation of teeth with open apices have a high survival rate. Future studies should standardise the reporting of clinical and radiographic findings, as well as the definition of outcomes.
Performance of serum neurofilament light chain in a wide spectrum of clinical courses of amyotrophic lateral sclerosis—a cross‐sectional multicenter study
Authors: Meyer Thomas , Salkic Erma , Grehl Torsten , Weyen Ute , Kettemann Dagmar , Weydt Patrick , Günther René , Lingor Paul , Koch Jan Christoph , Petri Susanne , Hermann Andreas , Prudlo Johannes , Großkreutz Julian , Baum Petra , Boentert Matthias , Metelmann Moritz , Norden Jenny , Cordts Isabell , Weishaupt Jochen H. , Dorst Johannes , Ludolph Albert , Koc Yasemin , Walter Bertram , Münch Christoph , Spittel Susanne , Dreger Marie , Maier André , Körtvélyessy Péter 
Published: March 2023

AbstractBackground and purposeThe objective was to assess the performance of serum neurofilament light chain (sNfL) in amyotrophic lateral sclerosis (ALS) in a wide range of disease courses, in terms of progression, duration and tracheostomy invasive ventilation (TIV).MethodsA prospective cross‐sectional study at 12 ALS centers in Germany was performed. sNfL concentrations were age adjusted using sNfL Z scores expressing the number of standard deviations from the mean of a control reference database and correlated to ALS duration and ALS progression rate (ALS‐PR), defined by the decline of the ALS Functional Rating Scale.ResultsIn the total ALS cohort (n = 1378) the sNfL Z score was elevated (3.04; 2.46–3.43; 99.88th percentile). There was a strong correlation of sNfL Z score with ALS‐PR (p < 0.001). In patients with long (5–10 years, n = 167) or very long ALS duration (>10 years, n = 94) the sNfL Z score was significantly lower compared to the typical ALS duration of <5 years (n = 1059) (p < 0.001). Furthermore, in patients with TIV, decreasing sNfL Z scores were found in correlation with TIV duration and ALS‐PR (p = 0.002; p < 0.001).ConclusionsThe finding of moderate sNfL elevation in patients with long ALS duration underlined the favorable prognosis of low sNfL. The strong correlation of sNfL Z score with ALS‐PR strengthened its value as progression marker in clinical management and research. The lowering of sNfL in correlation with long TIV duration could reflect a reduction either in disease activity or in the neuroaxonal substrate of biomarker formation during the protracted course of ALS.
Association of aberrant brain network dynamics with gut microbial composition uncovers disrupted brain–gut–microbiome interactions in irritable bowel syndrome: Preliminary findings
Authors: Yang Lin , Liu Guangyao , Li Shan , Yao Chaofan , Zhao Ziyang , Chen Nan , Zhang Pengfei , Shang Yingying , Wang Yin , Zhang Dekui , Tian Xiaozhu , Zhang Jing , Yao Zhijun , Hu Bin 
Published: March 2023

AbstractBackground and purposeGrowing evidence suggests that abnormalities in brain–gut–microbiome (BGM) interactions are involved in the pathogenesis of irritable bowel syndrome (IBS). Our study aimed to explore alterations in dynamic functional connectivity (DFC), the gut microbiome and the bidirectional interaction in the BGM.MethodsResting‐state functional magnetic resonance imaging (rs‐fMRI), fecal samples and clinical chacteristics were collected from 33 IBS patients and 32 healthy controls. We performed a systematic DFC analysis on rs‐fMRI. The gut microbiome was analyzed by 16S rRNA gene sequencing. Associations between DFC characteristics and microbial alterations were explored.ResultsIn the DFC analysis, four dynamic functional states were identified. IBS patients exhibited increased mean dwell and fraction time in State 4, and reduced transitions from State 3 to State 1. Aberrant temporal properties in State 4 were only evident when choosing a short window (36 s or 44 s). Decreased functional connectivity (FC) variability was found in State 1 and State 3 in IBS patients, two of which (independent component [IC]51‐IC91, IC46‐IC11) showed significant correlations with clinical characteristics. Additionally, we identified nine significantly differential abundances in microbial composition. We also found that IBS‐related microbiota were associated with aberrant FC variability, although these exploratory results were obtained at an uncorrected threshold of significance.ConclusionsAlthough future studies are needed to confirm our results, the findings not only provide a new insight into the dysconnectivity hypothesis in IBS from a dynamic perspective, but also establish a possible link between DFC and the gut microbiome, which lays the foundation for future research on disrupted BGM interactions.
Environmental, geographical and time‐related impacts on avian malaria infections in native and introduced populations of house sparrows (Passer domesticus), a globally invasive species
Authors: Ferraguti Martina , Magallanes Sergio , Jiménez‐Peñuela Jéssica , Martínez‐de la Puente Josué , Garcia‐Longoria Luz , Figuerola Jordi , Muriel Jaime , Albayrak Tamer , Bensch Staffan , Bonneaud Camille , Clarke Rohan H. , Czirják Gábor Á. , Dimitrov Dimitar , Espinoza Kathya , Ewen John G. , Ishtiaq Farah , Flores‐Saavedra Wendy , Garamszegi László Zsolt , Hellgren Olof , Horakova Dita , Huyvaert Kathryn P. , Jensen Henrik , Križanauskienė Asta , Lima Marcos R. , Lujan‐Vega Charlene , Magnussen Eyðfinn , Martin Lynn B. , Matson Kevin D. , Møller Anders Pape , Munclinger Pavel , Palinauskas Vaidas , Pap Péter L. , Pérez‐Tris Javier , Renner Swen C. , Ricklefs Robert , Scebba Sergio , Sehgal Ravinder N. M. , Soler Manuel , Szöllősi Eszter , Valkiūnas Gediminas , Westerdahl Helena , Zehtindjiev Pavel , Marzal Alfonso 
Published: March 2023

AbstractAimThe increasing spread of vector‐borne diseases has resulted in severe health concerns for humans, domestic animals and wildlife, with changes in land use and the introduction of invasive species being among the main possible causes for this increase. We explored several ecological drivers potentially affecting the local prevalence and richness of avian malaria parasite lineages in native and introduced house sparrows (Passer domesticus) populations.LocationGlobal.Time period2002–2019.Major taxa studiedAvian Plasmodium parasites in house sparrows.MethodsWe analysed data from 2,220 samples from 69 localities across all continents, except Antarctica. The influence of environment (urbanization index and human density), geography (altitude, latitude, hemisphere) and time (bird breeding season and years since introduction) were analysed using generalized additive mixed models (GAMMs) and random forests.ResultsOverall, 670 sparrows (30.2%) were infected with 22 Plasmodium lineages. In native populations, parasite prevalence was positively related to urbanization index, with the highest prevalence values in areas with intermediate urbanization levels. Likewise, in introduced populations, prevalence was positively associated with urbanization index; however, higher infection occurred in areas with either extreme high or low levels of urbanization. In introduced populations, the number of parasite lineages increased with altitude and with the years elapsed since the establishment of sparrows in a new locality. Here, after a decline in the number of parasite lineages in the first 30 years, an increase from 40 years onwards was detected.Main conclusionsUrbanization was related to parasite prevalence in both native and introduced bird populations. In invaded areas, altitude and time since bird introduction were related to the number of Plasmodium lineages found to be infecting sparrows.
Amphibian traits database: A global database on morphological traits of amphibians
Authors: Huang Na , Sun Xinyuan , Song Yanfang , Yuan Zhiyong , Zhou Weiwei 
Published: March 2023

AbstractMotivationAmphibians are a diverse vertebrate group with more than 8,000 species, which is an important part of major terrestrial and freshwater ecosystems. Unfortunately, amphibians are experiencing a worldwide population decline. Trait information is important for understanding the causes of endangerment. Additionally, such information is essential for ecological and evolutionary studies using trait‐based approaches. However, such data are scarcer for amphibians than for any other terrestrial vertebrate groups. To fill this gap, we collected morphological traits of global amphibians available from the literature and compiled a database to facilitate future studies.Main types of variables containedForty‐two morphological traits of Anura, 27 morphological traits of Caudata and 37 morphological traits of Gymnophiona.Spatial location and grainGlobal.Major taxaAmphibia.Level of measurementSpecies.Software format.csv.
The relationship between foreign direct investment and domestic entrepreneurship: The impact and scale of investments in China
Authors: Thompson Piers , Zang Wenyu 
Published: March 2023

AbstractBoth entrepreneurship and foreign direct investment (FDI) are frequently identified as being sources of local and regional economic growth. However, the relationship between the two is not always clear, with a negative competition effect and a positive demand effect potentially present. China provides an interesting case to study with its large state‐owned sector, combined with a recent history of successfully attracting considerable FDI. This study examines the relationship between self‐employment and different elements of foreign influence (FI) at a provincial level. The results imply that foreign investment reduces the level of self‐employment, whilst the number of foreign enterprises and foreign exports have positive effects. The results therefore show the importance in considering multiple perspectives in terms of FI. It appears that policies that attract individual large investments suppress the development of domestic enterprise as predicted by the competition effect, but where more foreign enterprises are present, and a cluster starts to develop, a demand effect appears to take over. This means that provincial government policy may need to be more nuanced to avoid economies being highly reliant on a limited number of what might be quite footloose larger foreign employers.
Frontal headache in a patient with right temporal epilepsy: A video‐EEG case report of ictal epileptic headache
Authors: Demarquay Geneviève , Sala Emilie , Adham Ahmed , Camdessanché Jean‐Philippe , Convers Philippe , Mazzola Laure 
Published: March 2023

AbstractBackgroundIctal epileptic headache (IEH) is caused by a focal epileptic seizure. The diagnosis can be challenging when the headache is isolated without any other symptoms.Case ReportA 16‐year‐old girl presented with a 5‐year history of bilateral frontotemporal headaches with severe intensity lasting for 1–3 min. Past medical, physical, and developmental histories were unremarkable. Head magnetic resonance imaging showed right hippocampal sclerosis. The diagnosis of pure IEH was confirmed by video‐electroencephalographic monitoring. The onset and cessation of frontal headache correlated with a right temporal discharge. The patient was diagnosed with right mesial temporal lobe epilepsy. Two years later, her seizures increased despite antiseizure medications. A right anterior temporal lobectomy was performed. The patient remained seizure‐free and headache‐free for 10 years.ConclusionIEH should be considered in the differential diagnosis of brief and isolated headache, even if the headache is diffuse or contralateral to the epileptogenic focus.
Mechanisms of change in posttraumatic headache–related disability: A mediation model
Authors: Nabity Paul S. , Reed David E. , McGeary Cindy A. , Houle Timothy T. , Jaramillo Carlos A. , Resick Patricia A. , Eapen Blessen C. , Litz Brett T. , Mintz Jim , Penzien Donald B. , Keane Terence M. , Young‐McCaughan Stacey , Peterson Alan L. , McGeary Donald D. ,   for the Consortium to Alleviate PTSD
Published: March 2023

AbstractObjectiveTo explore whether the association between change in headache management self‐efficacy and posttraumatic headache–related disability is partially mediated by a change in anxiety symptom severity.BackgroundMany cognitive–behavioral therapy treatments for headache emphasize stress management, which includes anxiety management strategies; however, little is currently known about mechanisms of change in posttraumatic headache–related disability. Increasing our understanding of mechanisms could lead to improvements in treatments for these debilitating headaches.MethodsThis study is a secondary analysis of veterans (N = 193) recruited to participate in a randomized clinical trial of cognitive–behavioral therapy, cognitive processing therapy, or treatment as usual for persistent posttraumatic headache. The direct relationship between headache management self‐efficacy and headache‐related disability, along with partial mediation through change in anxiety symptoms was tested.ResultsThe mediated latent change direct, mediated, and total pathways were statistically significant. The path analysis supported a significant direct pathway between headache management self‐efficacy and headache‐related disability (b = −0.45, p < 0.001; 95% confidence interval [CI: −0.58, −0.33]). The total effect of change of headache management self‐efficacy scores on change in Headache Impact Test‐6 scores was significant with a moderate‐to‐strong effect (b = −0.57, p = 0.001; 95% CI [−0.73, −0.41]). There was also an indirect effect through anxiety symptom severity change (b = −0.12, p = 0.003; 95% CI [−0.20, −0.04]).ConclusionsIn this study, most of the improvements in headache‐related disability were related to increased headache management self‐efficacy with mediation occurring through change in anxiety. This indicates that headache management self‐efficacy is a likely mechanism of change of posttraumatic headache–related disability with decreases in anxiety explaining part of the improvement in headache‐related disability.
Patient‐reported experiences with migraine‐related cognitive symptoms: Results of the MiCOAS qualitative study
Authors: Gerstein Maya T. , Wirth R. J. , Uzumcu Alyssa A. , Houts Carrie R. , McGinley James S. , Buse Dawn C. , McCarrier Kelly P. , Cooke Alexis , Touba Nancy M. , Nishida Tracy K. , Goadsby Peter J. , Dodick David W. , Lipton Richard B. 
Published: March 2023

AbstractObjectivesTo capture patients' perspectives on migraine‐related cognitive symptoms during pre‐headache, headache, post‐headache, and interictal periods.BackgroundMigraine‐related cognitive symptoms are reported by people with migraine both during and between attacks. Associated with disability, they are increasingly viewed as a priority target for treatment. The Migraine Clinical Outcome Assessment System (MiCOAS) project is focused on developing a patient‐centered core set of outcome measures for the evaluation of migraine treatments. The project focuses on incorporating the experience of people living with migraine and the outcomes most meaningful to them. This includes an examination of the presence and functional impact of migraine‐related cognitive symptoms and their perceived impact on quality of life and disability.MethodsForty individuals with self‐reported medically diagnosed migraine were recruited via iterative purposeful sampling for semi‐structured qualitative interviews conducted using audio‐only web conferencing. Thematic content analysis was performed to identify key concepts around migraine‐related cognitive symptoms. Recruitment continued until concept saturation was achieved.ResultsParticipants described symptoms consistent with migraine‐related deficits in language/speech, sustained attention, executive function, and memory that manifest during pre‐headache (36/40 [90%] reported ≥1 cognitive feature), headache (35/40 [88%] reported ≥1 cognitive feature), post‐headache (27/40 [68%] reported ≥1 cognitive feature), and interictal periods (13/40 [33%] reported ≥1 cognitive feature). Among participants reporting cognitive symptoms during pre‐headache, 32/40 (81%) endorsed 2–5 cognitive symptoms. Findings were similar during the headache phase. Participants reported language/speech problems consistent with, for example, impairments in receptive language, expressive language, and articulation. Issues with sustained attention included fogginess, confusion/disorientation, and trouble with concentration/focus. Deficits in executive function included difficulty processing information and reduced capacity for planning and decision‐making. Memory issues were reported across all phases of the migraine attack.ConclusionsThis patient‐level qualitative study suggests that cognitive symptoms are common for persons with migraine, particularly in the pre‐headache and headache phases. These findings highlight the importance of assessing and ameliorating these cognitive problems.