bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insecticide resistance status of Aedes aegypti and Aedes albopictus mosquitoes in southern Benin, West Africa
Authors: Konkon Alphonse Keller , Padonou Germain Gil , Osse Razaki , Salako Albert Sourou , Zoungbédji David Mahouton , Sina Haziz , Sovi Arthur , Tokponnon Filemon , Aïkpon Rock , Noukpo Herbert , Baba-Moussa Lamine , Akogbéto Martin Codjo 
Published: April 2023

Abstract
Background
The emergence of insecticide resistance in Aedes mosquitoes could undermine efforts to control arboviruses. The present study aims to assess in some communes of Southern Benin, the susceptibility level of Aedes aegypti (Linnaeus, 1762) and Aedes albopictus (Skuse, 1894) to insecticides commonly used in public health, as well as mechanisms involved.

Methods
Females Ae. albopictus and Ae. aegypti collected in Ifangni, Porto-Novo, Avrankou, Adjarra and Kétou from June 2021 to October 2022, were exposed to: deltamethrin 0.05%, permethrin 0.75%, alpha-cypermethrin 0.05%, pirimiphos methyl 0.25% and bendiocarb 0.1%, following the standard WHO susceptibility tube test protocol. In some sites, pre-exposure to the synergist PBO was used to verify if pyrethroid resistance of populations of Aedes was mediated by oxidases.

Results
Full susceptibility to deltamethrin and permethrin was observed in all tested populations of Ae. albopictus. However, with alphacypermethrin, a suspected resistance was observed in Adjarra (94.67%), Ifangni (93%) and Porto-Novo (94%), and a resistance in Avrankou (83%). The PBO-alphacypermethrin tests performed, led to a full susceptibility (100%) in all four sites, which confirms the full involvement of oxidases in resistance of all tested populations of Ae. albopictus to alphacypermethrin. At the opposite, Aedes aegypti was either resistant or suspected of being resistant to all tested pyrethroids in all four sites, except in Ifangni where a full susceptibility to alphacypermethrin was observed. The full susceptibility of Ae. aegypti to bendiocarb and pirimiphos-methyl in all communes suggests that these two insecticides can be good candidates for an effective control of pyrethroid-resistant Aedes vector populations. Use of permethrin and deltamethrin could also be considered for controlling populations of Ae. albopictus.

Conclusion
Results of the present study will help guide strategy to implement for an effective control of Aedes vector populations in Benin.
Sleep Patterns, Plasma Metabolome, and Risk of Incident Type 2 Diabetes Mellitus
Authors: Zhuang Zhenhuang , Dong Xue , Jia Jinzhu , Liu Zhonghua , Huang Tao , Qi Lu 
Published: April 2023

Abstract

Context
A healthy sleep pattern has been related to a lower risk of type 2 diabetes mellitus (T2DM).

Objective
We aimed to identify the metabolomic signature for the healthy sleep pattern and assess its potential causality with T2DM.

Methods
This study included 78 659 participants with complete phenotypic data (sleep information and metabolomic measurements) from the UK Biobank study. Elastic net regularized regression was applied to calculate a metabolomic signature reflecting overall sleep patterns. We also performed genome-wide association analysis of the metabolomic signature and one-sample mendelian randomization (MR) with T2DM risk.

Results
During a median of 8.8 years of follow-up, we documented 1489 incident T2DM cases. Compared with individuals who had an unhealthy sleep pattern, those with a healthy sleep pattern had a 49% lower risk of T2DM (multivariable-adjusted hazard ratio [HR], 0.51; 95% CI, 0.40-0.63). We further constructed a metabolomic signature using elastic net regularized regressions that comprised 153 metabolites, and robustly correlated with sleep pattern (r = 0.19; P = 3×10−325). In multivariable Cox regressions, the metabolomic signature showed a statistically significant inverse association with T2DM risk (HR per SD increment in the signature, 0.56; 95% CI, 0.52-0.60). Additionally, MR analyses indicated a significant causal relation between the genetically predicted metabolomic signature and incident T2DM (P for trend &lt; .001).

Conclusion
In this large prospective study, we identified a metabolomic signature for the healthy sleep pattern, and such a signature showed a potential causality with T2DM risk independent of traditional risk factors.
Association of Resting Heart Rate Trajectories With Cardiovascular Disease and Mortality in Patients With Diabetes Mellitus
Authors: Wang Chi , Xin Qian , Zheng Mengyi , Liu Shihe , Yao Siyu , Li Yanjie , Tian Lu , Feng Zekun , Wang Miao , Zhao Maoxiang , Chen Shuohua , Wu Shouling , Xue Hao 
Published: April 2023

Abstract

Context
Longitudinal patterns of resting heart rate (RHR) in patients with diabetes mellitus and their association with health outcomes are not well-characterized.

Objective
We sought to explore the RHR trajectories in patients with diabetes mellitus and their association with cardiovascular disease (CVD) and all-cause mortality.

Design
The Kailuan Study is a prospective cohort study. Participants underwent health examinations biennially starting in 2006 and were followed until December 31, 2020.

Setting
General community.

Participants
A total of 8218 diabetic participants who attended at least 3 of the examinations conducted in 2006, 2008, 2010, and 2012 were included.

Main outcome measures
CVD and all-cause mortality.

Results
We identified 4 RHR trajectories in participants with diabetes mellitus between 2006 and 2012: low-stable (range, 66.83-64.91 beats/min; n = 1705), moderate-stable (range, 76.30-76.95 beats/min; n = 5437), high-decreasing (mean decreased from 92.14 to 85.60 beats/min; n = 862), and high-increasing (mean increased from 84.03 to 111.62 beats/min; n = 214). During an average follow-up of 7.25 years, 977 cases of CVD and 1162 deaths were identified. Compared with the low-stable trajectory, adjusted hazard ratios (HRs) for CVD were 1.48 (95% CI, 1.02-2.14; P = .04) for the high-increasing trajectory, adjusted HRs for all-cause mortality were 1.34 (95% CI, 1.14-1.58; P &lt; .01) for the moderate-stable trajectory, 1.68 (95% CI, 1.35-2.10; P &lt; .01) for the high-decreasing trajectory, and 2.47 (95% CI, 1.85-3.31; P &lt; .01) for the high-increasing trajectory.

Conclusions
RHR trajectories were associated with the subsequent risks of CVD and all-cause mortality in patients with diabetes mellitus.
Risk of Thyroid Dysfunction in PD-1 Blockade Is Stratified by the Pattern of TgAb and TPOAb Positivity at Baseline
Authors: Zhou Xin , Iwama Shintaro , Kobayashi Tomoko , Ando Masahiko , Arima Hiroshi 
Published: April 2023

Abstract

Context
Positive antithyroglobulin (TgAb) and/or antithyroid peroxidase antibodies (TPOAb) at baseline indicate a high risk of thyroid immune-related adverse events (irAEs) induced by antiprogrammed cell death-1 antibodies (anti-PD-1-Ab). However, whether the positivity patterns of both antibodies are associated with the risk of thyroid irAEs is unknown.

Objective
The aim of the present study was to clarify the association of the pattern of TgAb and TPOAb positivity at baseline with the risk of thyroid irAEs induced by anti-PD-1-Ab.

Methods
Patients (n = 516) were evaluated for TgAb and TPOAb at baseline and prospectively for thyroid function every 6 weeks for 24 weeks after initiating anti-PD-1-Ab.

Results
Fifty-one (9.9%) patients developed thyroid irAEs (thyrotoxicosis in 34, hypothyroidism without prior thyrotoxicosis in 17). Twenty-five patients subsequently developed hypothyroidism following thyrotoxicosis. The cumulative incidence of thyroid irAEs differed among 4 groups classified by the presence of TgAb/TPOAb at baseline (group 1: TgAb-(−)/TPOAb-(−), 4.6% [19/415]; group 2: TgAb-(−)/TPOAb-(+), 15.8% [9/57]; group 3: TgAb-(+)/TPOAb-(−), 42.1% [8/19]; group 4: TgAb-(+)/TPOAb-(+), 60.0% [15/25]) as follows: groups 1 vs 2-4 (P ≤ .001) and groups 2 vs 3 (P = .008) and 4 (P &lt; .001). There were different incidences of thyrotoxicosis (groups 1-4, 3.1%, 5.3%, 31.6%, 48.0%, respectively; P &lt; .001) in groups 1 vs 3 and 4, and groups 2 vs 3 and 4, and of hypothyroidism (groups 1-4: 2.9%, 15.8%, 31.6%, 60.0%, respectively; P &lt; .001) in groups 1 vs 2 to 4, and groups 2 vs 4.

Conclusion
The risk of thyroid irAEs was affected by the pattern of TgAb and TPOAb positivity at baseline; there were high risks of thyrotoxicosis in patients with TgAb-(+) and of hypothyroidism in patients with TgAb-(+) and those with TPOAb-(+).
DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement
Authors: Malla Aushaq B. , Rainsford Shannon R. , Smith Zachary D. , Lesch Bluma J. 
Published: April 2023

ABSTRACT
Unique chromatin remodeling factors orchestrate dramatic changes in nuclear morphology during differentiation of the mature sperm head. A crucial step in this process is histone-to-protamine exchange, which must be executed correctly to avoid sperm DNA damage, embryonic lethality and male sterility. Here, we define an essential role for the histone methyltransferase DOT1L in the histone-to-protamine transition. We show that DOT1L is abundantly expressed in mouse meiotic and postmeiotic germ cells, and that methylation of histone H3 lysine 79 (H3K79), the modification catalyzed by DOT1L, is enriched in developing spermatids in the initial stages of histone replacement. Elongating spermatids lacking DOT1L fail to fully replace histones and exhibit aberrant protamine recruitment, resulting in deformed sperm heads and male sterility. Loss of DOT1L results in transcriptional dysregulation coinciding with the onset of histone replacement and affecting genes required for histone-to-protamine exchange. DOT1L also deposits H3K79me2 and promotes accumulation of elongating RNA Polymerase II at the testis-specific bromodomain gene Brdt. Together, our results indicate that DOT1L is an important mediator of transcription during spermatid differentiation and an indispensable regulator of male fertility.
The bumpy road ahead: the role of substrate roughness on animal walking and a proposed comparative metric
Authors: Clifton Glenna , Stark Alyssa Y. , Li Chen , Gravish Nicholas 
Published: April 2023

ABSTRACTOutside laboratory conditions and human-made structures, animals rarely encounter flat surfaces. Instead, natural substrates are uneven surfaces with height variation that ranges from the microscopic scale to the macroscopic scale. For walking animals (which we define as encompassing any form of legged movement across the ground, such as walking, running, galloping, etc.), such substrate ‘roughness’ influences locomotion in a multitude of ways across scales, from roughness that influences how each toe or foot contacts the ground, to larger obstacles that animals must move over or navigate around. Historically, the unpredictability and variability of natural environments has limited the ability to collect data on animal walking biomechanics. However, recent technical advances, such as more sensitive and portable cameras, biologgers, laboratory tools to fabricate rough terrain, as well as the ability to efficiently store and analyze large variable datasets, have expanded the opportunity to study how animals move under naturalistic conditions. As more researchers endeavor to assess walking over rough terrain, we lack a consistent approach to quantifying roughness and contextualizing these findings. This Review summarizes existing literature that examines non-human animals walking on rough terrain and presents a metric for characterizing the relative substrate roughness compared with animal size. This framework can be applied across terrain and body scales, facilitating direct comparisons of walking over rough surfaces in animals ranging in size from ants to elephants.
Biomechanics, motor control and dynamic models of the soft limbs of the octopus and other cephalopods
Authors: Flash Tamar , Zullo Letizia 
Published: April 2023

ABSTRACT
Muscular hydrostats are organs composed entirely of packed arrays of incompressible muscles and lacking any skeletal support. Found in both vertebrates and invertebrates, they are of great interest for comparative biomechanics from engineering and evolutionary perspectives. The arms of cephalopods (e.g. octopus and squid) are particularly interesting muscular hydrostats because of their flexibility and ability to generate complex behaviors exploiting elaborate nervous systems. Several lines of evidence from octopus studies point to the use of both brain and arm-embedded motor control strategies that have evolved to simplify the complexities associated with the control of flexible and hyper-redundant limbs and bodies. Here, we review earlier and more recent experimental studies on octopus arm biomechanics and neural motor control. We review several dynamic models used to predict the kinematic characteristics of several basic motion primitives, noting the shortcomings of the current models in accounting for behavioral observations. We also discuss the significance of impedance (stiffness and viscosity) in controlling the octopus's motor behavior. These factors are considered in light of several new models of muscle biomechanics that could be used in future research to gain a better understanding of motor control in the octopus. There is also a need for updated models that encompass stiffness and viscosity for designing and controlling soft robotic arms. The field of soft robotics has boomed over the past 15 years and would benefit significantly from further progress in biomechanical and motor control studies on octopus and other muscular hydrostats.
Το μυθοπλαστικό βίντεο «Το νήμα» ως διδακτικό εργαλείο ευαισθητοποίησης των εφήβων στο πλαίσιο της Ανάπτυξης Ψηφιακού Οπτικοακουστικού Υλικού
Authors: Πλατανιώτη Χριστίνα , Σοφός Αλιβίζος (Λοΐζος) 
Published: April 2023

Γενικός στόχος του παρόντος άρθρου είναι η διερεύνηση της μυθοπλαστικής ταινίας μικρού μήκους εκπαιδευτικού περιεχομένου «Το νήμα -μιλάς με τη σιωπή σου-» που δημιουργήθηκε στα πλαίσια του μαθήματος «Ανάπτυξη Ψηφιακού Οπτικοακουστικού Υλικού» με διδάσκοντα τον κύριο Σοφό Αλιβίζο. Η συγκεκριμένη ταινία μυθοπλασίας, η οποία συμπεριλαμβάνει και στοιχεία ντοκιμαντέρ, καθώς και η εκπαιδευτική αξιοποίηση της άνω ταινίας προσεγγίζουν τον εθισμό στο gaming μέσα από τη σκιαγράφηση της καθημερινότητας του ήρωα. Ταυτοχρόνως όμως παρουσιάζονται τα βασικά συμπτώματα του εθισμού καθώς και στατιστικά δεδομένα που έχουν αντληθεί από επιστημονικές μελέτες σε συνεργασία με την επιστημονική ομάδα του ΚΕΘΕΑ. Πρόκειται για ένα φαινόμενο που αποκτά όλο και μεγαλύτερες διαστάσεις τα τελευταία χρόνια με τις έρευνες να αναδεικνύουν ανησυχητικά στοιχεία για τις επιπτώσεις στους νέους. Η εύκολη πρόσβαση στο Διαδίκτυο και η υπερβολική χρήση από τους εφήβους δημιουργεί ένα αυξανόμενο κλίμα ανησυχίας. Στόχος της ταινίας και των δραστηριοτήτων που προτείνονται είναι η ενημέρωση, η ευαισθητοποίηση και ο προβληματισμός των νέων σχετικά με τον εθισμό στο διαδίκτυο και συγκεκριμένα τον εθισμό στο gaming.
Human Gut Microbiome – how intestinal bacteria influence our health
Authors: Kuźniar Aleksandra , Szawica Dominik , Wąsiewicz Edward , Fularska Kamila , Oleszko Michał 
Published: April 2023

Introduction: Gut microbiome is composed of hundreds of different bacterial species.Possibly every type of bacteria can affect many different aspects of human healthGut bacterial composition varies immensely between healthy and sick people and there are many factors which can influence micriobiota balance in our intestines.
Aim of study: The purpose of the study was to review the latest literature on the gut bacteria importance and to discover what factors can influence gut microbiome composition.
Matherials and methods: A systemic review was conducted using Google Scholar, PubMed and ScienceDirect databases and the search was limited to studies published between 2000 and 2023. The search strategy was based on following terms: microbiome, gut bacteria, health and microbiome, gut microflora, human intestinal microbiota
Results: We found many different studies which show importance of gut microflora in various different ailments and diseases, we have also found many showing factors that influence intestinal microbiota composition.Conclusions: Gut microbiota is very broad topic – it can affect many different aspects of human health, starting from lowering the risk of developing allergy or affecting weight loss to affecting risk of colorectal cancer development . It can be affected by many different factors – lots of them are still uknown and need further studies.
Influence of Epstein-Barr virus infection on developing multiple sclerosis
Authors: Ołownia Aleksandra , Orczyk Jakub , Kozioł Małgorzata 
Published: April 2023

Multiple sclerosis (MS) is the most common inflammatory-demyelinating disease. MS leads to the multifocal damage of the central nervous system, which causes the gradual deterioration of sensory, motor and cognitive functions. The etiology of this disease is not fully understood, but genetic and environmental factors (including the EBV infection) are suspected. In this review, we would like to summarize the state of knowledge over the effect of Epstein-Barr virus infection on developing multiple sclerosis.
Infectious mononucleosis (IM) which is caused by EBV and MS have similar epidemiology: both diseases mainly affect people at a young age, geographical prevalence is also identical. There are many theories that explain the mechanism of the EBV involvement in the development of MS including: the migration of EBV-infected B cells into the Central Nervous System, the theory of molecular mimicry, the induction of αB-crystallin by EBV in lymphoid cells or cooperation of the EBV and other viruses in the development of MS. Observations by physicians from around the world suggest that EBV infection is a strong factor in the development of multiple sclerosis. Epstein-Barr virus is prevalent in the population. There are a lot of evidences that suggest its involvement in the development of multiple sclerosis. Prevention of EBV infection could potentially reduce the amount of cases of MS. However, more researches are needed to clearly confirm the involvement of EBV in the etiopathogenesis of developing MS.
The Case for Cross-entity Delta Encoding in Web Compression (Extended)
Authors: Wollmer Benjamin , Wingerath Wolfram , Ferrlein Sophie , Panse Fabian , Gessert Felix , Ritter Norbert 
Published: April 2023

Delta encoding and shared dictionary compression (SDC) for accelerating Web content have been studied extensively in research over the last two decades, but have only found limited adoption in the industry so far; compression approaches that use a custom-tailored dictionary per website have all failed in practice due to lacking browser support and high overall complexity. General-purpose SDC approaches such as Brotli reduce complexity by shipping the same dictionary for all use cases, while most delta encoding approaches just consider similarities between versions of the same entity (but not between different entities). In this study, we investigate how much of the potential benefits of SDC and delta encoding are left on the table by these two simplifications. As our first contribution, we describe the idea of cross-entity delta encoding that uses cached assets from the immediate browser history for content encoding instead of a precompiled shared dictionary; this avoids the need to create a custom dictionary, but enables highly customized and efficient compression. Second, we present an experimental evaluation of compression efficiency to hold cross-entity delta encoding against state-of-the-art Web compression algorithms. We consciously compare algorithms some of which are not yet available in browsers to understand their potential value before investing resources to build them. Our results indicate that cross-entity delta encoding is over 50% more efficient for text-based resources than compression industry standards. We hope our findings motivate further research and development on this topic.
The extended version of our previously published paper [10] includes an additional section on the deltas of HTML files, a more detailed description of our approach (including a new visualization for the different dictionary strategies), a deeper discussion of compression efficiency, and details on additional future and ongoing work.
Prevalence and predictors of musculoskeletal health complaints among sedentary, monotonous urban workers: A survey in Bangladesh
Authors: Ali Mohammad , Siddiq Md. Abu Bakar , Pranto Nujaim Khan , Amran Naheean Hossain , Akter Marium , Munny Marjan Akter , Hossain Md. Imran , Khan Saffat Sabbir , Mehedi Md. Murad Hossain 
Published: April 2023

BackgroundMonotonous and sedentary work is significantly associated with the worst health of workers. There is a scarcity of data investigating the musculoskeletal health of sedentary workers working in low-income and middle-income settings. This study aimed to measure the prevalence and predictors of musculoskeletal health complaints (MHC) among Bangladeshi shopkeepers.MethodsThis cross-sectional study was conducted in Dhaka, Bangladesh. Data from 1553 Bangladeshi shopkeepers aged 18 years and above were analyzed. MHC was measured using the musculoskeletal subscale of the subjective health complaints scale. The descriptive analysis helped to compute MHC prevalence and compare the prevalence across groups. Regression analysis revealed the predictors of MHC for the shopkeepers.ResultsThe prevalence of MHC among shopkeepers was 58.0%. The prevalence of low back pain was the highest (55.5%), followed by neck pain (48.0%) and upper back pain (43.5%). Regression analysis identified sex (aOR 1.301, CI 0.996 to 1.700), age (aOR 1.405, CI 1.047 to 1.886), body mass index (aOR 0.495, CI 0.397 to 0.617), and substance abuse (aOR 1.998, CI 1.136 to 3.514) as independent predictors of MHC among the shopkeepers. Furthermore, significantly higher odds of MHC have been found among tobacco users (OR 1.234, CI 1.009 to 1.510).ConclusionThis study revealed a high prevalence of MHC and unhealthy lifestyles among shopkeepers in Bangladesh. Shopkeepers should be provided with better health literacy to follow healthy lifestyles and prevent MHC among this cohort.