bluuebunny/crossref_metadata_2025_split huggingface dataset:
“You Shall Not Marry a Canaanite!” Endogamy, (Canaanite) Exogamy and Theology in Genesis 12–50
Authors: Ford William 
Published: August 2023

Abstract
In Gen 12–50 the interactions between the patriarchs and the Canaanites are more positive than in the later Hebrew Scriptures, with the exception of the ban on marriage. This article examines the relevant passages in Genesis (24; 26:34–28:9; 34 and especially 38), reading them canonically, particularly in light of the patriarchal promises which form a key underlying theme of the patriarchal narratives. It is argued that while the passages discourage exogamy, the situation is more complex than a simple ban. This is particularly so in the case of Tamar (Gen 38). While (probably) Canaanite she is the hero of the story and the ancestor of both David and Jesus, becoming an important part of the fulfilment of the promises. A brief comparison with the conquest narratives suggest that this complexity is also evident there, and that the focus is not on ethnicity but on one’s attitude to YHWH.
Serum endocan as a predictive biomarker of cardiovascular risk in obese pediatric patients
Authors: Morace Carmela , Curatola Selenia Lorenza , Mandraffino Giuseppe , Scuruchi Michele , Serrano’ Angela Elvira , Tropeano Angelo , Lombardo Fortunato , Salzano Giuseppina , Squadrito Giovanni , Versace Antonio Giovanni , Valenzise Mariella 
Published: August 2023

Abstract
Background
Endocan is a soluble dermatan sulfate proteoglycan (50 kDa) secreted by endothelial cells and expressed by dermal, coronary, pulmonary and adipose tissue microvasculature. It plays an important role in the pathogenesis of vascular disorders, inflammatory state, endothelium dysfunction and neoangiogenesis. Aims of the study were to compare fasting serum endocan levels between children with obesity and healthy controls and to investigate the relationships between endocan, body mass index (BMI) and other indices of cardiometabolic risk.

Methods
This single-center, observational, retrospective study included 19 pediatric patients with obesity aged 11.94 ± 0.52 years and 19 lean matched controls. Each patient underwent clinical and auxological examination and laboratory investigations including routine organs function tests and lipid profile. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Fasting endocan serum levels were measured using an enzyme-linked immunosorbent assay (ELISA).

Results
Compared to healthy subjects, serum endocan levels were found to be significantly upraised in children with obesity. Endocan resulted significantly correlated with insulin levels (rho 0.47; p = 0.04); in addition, an association with HOMA-IR values with a trend toward the statistical significance (rho 0.43; p = 0.07) was found. No significant correlation with fasting blood glucose values and lipid serum levels was demonstrated. Although not statistically significant, a correlation between endocan and the presence and grading of liver steatosis on ultrasound (rho 0.51; p = 0.08 and rho 0.51; p = 0.08, respectively) was found.

Conclusions
These findings confirm the association between endothelial damage and insulin resistance in children with obesity. Endocan could be used as a biomarker of early endothelial dysfunction in children with obesity and could be a valid predictor of future cardiovascular risk in adulthood.
Health-related quality of life and its determinants in patients with different dermatological disorders at the University of Gondar Comprehensive Specialized Hospital
Authors: Belachew Eyayaw Ashete , Sendekie Ashenafi Kibret 
Published: August 2023

Abstract
Objectives
Evidence shows that majority of dermatological disorders affect the health-related quality of life (HRQoL) of patients. However, the extent of its negative impact and predictors has not been studied in Ethiopia. Thus, this study looked at assessing the HRQoL and determinants in patients with dermatological disorders (DDs) attending the University of Gondar Comprehensive Specialized Hospital (UoGCSH).

Results
Patients with dermatological disorders (n = 400) were included in the final analysis using a systematic random sampling technique. The mean age of the participants was 39.79 (± 17.17) years. The average (± SD) score of EQ-5D-5 L was 1.92 (± 0.74). Regarding domains, pain/discomfort accounted for a higher proportion 59 (22.3%) followed by anxiety/depression 61 (15.3%). Receiving topical preparations (β = -0.399, 95% CI: -0.6, − 0.19; < 0.001), systemic only medication (β = -0.378, 95% CI: -0.607, -0.149; p = 0.002), having slight, mild, and moderate skin diseases found to have an inverse association with impaired HRQoL, (β = -0.654, 95% CI; -1.01, -0.290); p < 0.001), (β = -0.748, 95% CI: -0.960, -0.538; p < 0.001), and (β = -0.465, 95% CI: -0.642, -0.283; p < 0.001), respectively. Furthermore, age (β = 0.011, 95% CI: 0.006, 0.016; p = 0.001), long duration with skin disease (β = 0.046, 95% CI: 0.015, 0.352; p = 0.013), and presence of comorbidity (β = 0.251, 95% CI: 0.096, 0.402; p = 0.002) were significant predictors of HRQoL among dermatological disease patients.

Conclusion
Patients with dermatological disease were found to have a compromised HRQoL. Pain /discomfort problems accounted for a higher proportion compared with other domains. Socio-demographic, clinical and medication-related variables were significantly associated with HRQoL.
Growing Healthy Hearts: a single-arm feasibility study of a digitally delivered gardening, cooking, and nutrition intervention for adults with risk factors for cardiovascular disease
Authors: Veldheer Susan , Whitehead-Zimmers Maxfield , Bordner Candace , Weinstein Olivia , Choi Hena , Spreenberg-Bronsoms Kira , Davis Jason , Conroy David E. , Schmitz Kathryn H. , Sciamanna Christopher 
Published: August 2023

Abstract
Background
Food gardening may positively influence cardiovascular disease (CVD) risk-related behaviors. However, the vast majority of existing gardening interventions have used an in-person delivery model which has limitations for scalability. It is not known whether a digitally delivered gardening intervention would be feasible or acceptable to participants. The purpose of this pilot study was to assess the feasibility of a digitally delivered gardening intervention in three domains: participant acceptability, demand, and practicality.

Methods
A single-arm, pre-post-study design was used. Participants (n = 30) were aged 20 + with no plans to garden in the coming season and had at least 1 CVD risk factor. The intervention included ten 1-h video-conferencing sessions, written materials, and access to a study website. Content focused on gardening skills, cooking skills, and the Dietary Approaches to Stop Hypertension (DASH) diet. Feasibility outcomes included acceptability (post-program ratings), demand (session attendance rate), and practicality (ability to start a garden and grow F&V). The study was considered feasible if the following criteria were met: ≥ 70% rated the intervention as good or excellent, overall session attendance rate was ≥ 70%, and > 70% were able to start a garden and grow F&V. We also assessed pre-post-program changes in behavioral mediators (gardening confidence, gardening enjoyment, cooking confidence, and nutrition knowledge). Descriptive statistics were calculated. Pre-post differences were evaluated with means and 95% confidence intervals (95% CI). Effect sizes were calculated (Cohen’s d).

Results
All feasibility criteria were met. A total of 93.3% of participants rated the intervention as good or excellent, 96% started a garden and grew F&V, and the overall session attendance rate was 81%. The largest mean pre-post changes were in gardening confidence (pre 7.1 [95% CI: 6.4, 7.9], post 9.0 [95% CI: 8.6, 9.5], Cohen’s d = 1.15), gardening enjoyment (pre: 6.3 [95% CI: 5.9, 6.7], post: 7.5 [95% CI: 7.1, 7.9], Cohen’s d = 1.69), and cooking self-efficacy (pre: 4.7 [95% CI: 4.3, 5.1], post: 7.7 [95% CI: 7.3, 8.0], Cohen’s d = 3.0).

Conclusion
A digitally delivered gardening intervention was feasible, acceptable to participants, and they had meaningful changes in behavioral mediators. The next step is to evaluate the impact of the intervention in a future randomized controlled trial.
Underwater laser positioning of targets outside the field of view based on a binocular vision
Authors: Li Jinhao , Cheng Jingxuan , Zhang Yufan , Jia Bowen , Zou Haiwu , Zhang Zejun , Xu Jing 
Published: August 2023

An underwater laser positioning scheme based on a binocular camera is introduced. In spite of the scattering, the underwater laser light path can be clearly captured by a camera within an appropriate range depending on the water turbidity. For an emitting laser with a fixed position, the three-dimensional information of the laser source can be calculated from the beam images captured by a binocular camera, even if the laser is out of the camera’s field of view (FOV). This method can break through the FOV limitation of traditional camera positioning and perform a 3D spatial positioning for the target even outside the FOV of the camera. We simulate and analyze the scattering light imaging and find that the laser propagation direction can be recognized from the scattering image. The experimental results show that the proposed underwater positioning scheme achieves an average 3D positioning error of 5.53 cm within a range of 5 m when the underwater attenuation is 0.325m−1.
Autologous micro-fragmented adipose tissue in the treatment of atherosclerosis patients with knee osteoarthritis in geriatric population: A systematic review and meta-analysis
Authors: Li Wei , Guo Huajuan , Wang Congcong , Zhang Yimin , Wang Jun 
Published: August 2023

Background
Atherosclerosis and osteoarthritis are closely related. However, no high-quality studies have investigated the potential of micro-fragmented adipose tissue to treat patients with atherosclerosis accompanied by osteoarthritis.

Methods
PubMed, Embase, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, WANFANG DATA, and CQVIP were searched for potentially eligible studies published before October 13, 2022. Due to the statistical limitations of the existing relevant literature, it is not possible to make direct statistics on the patients with osteoarthritis accompanied by atherosclerosis treated by micro-fragmented adipose tissue. The primary outcome consisted of two parts: 1) Correlation between atherosclerosis and osteoarthritis; 2) Scores of the Knee injury and Osteoarthritis Outcome Score (KOOS). And secondary outcomes were pain assessed by visual analog scale (VAS) or numeric rating scale (NRS), quality of life (QoL) (assessed using tools apart from the KOOS), and adverse events (AEs). Random meta-analysis was conducted using STATA 14.0.

Results
Nineteen studies were included. The metaanalysis evidenced a positive association between atherosclerosis and osteoarthritis (OR 1.17, CI 1.01–1.36). The mean absolute difference in KOOS subscale scores between pre- and post-treatment (mean with 95% confidence interval [CI]) was 19.65 (13.66, 25.63), 14.20 (4.64, 23.76), 19.95 (13.02, 26.89), 25.23 (14.80, 35.66), and 26.01 (13.68, 38.35) for pain, symptoms, activities of daily living (ADL), sports/recreation, and quality-of-life (QOL), respectively. The mean differences in VAS, resting VAS, activity VAS, and NRS between pre- and post-treatment was -8.24 (-10.66, —5.82), -3.61 (-4.49, -2.72), -4.17 (-4.89, -3.44), and -2.17 (-4.06, and -0.28), respectively. The mean difference in score of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), EQ-5D, and University of California in Los Angeles (UCLA) between pre- and post-treatment was -24.81 (-40.80, -8.82), 0.07 (0.02, 0.12), and 0.30 (-0.42, 1.02), respectively. The mean difference in Tegner score and the International Knee Documentation Committee (IKDC) score between pre- and post-treatment was 0.67 (-0.62, 1.97) and 13.70 (6.35, 21.04), respectively. The use of micro-fragmented adipose tissue was associated with risk of bruising, bleeding, hematoma, drainage, infection, soreness, swelling, pain, and stiffness in harvest and injection sites.

Conclusion
Atherosclerosis and osteoarthritis share common risk factors and comorbidity. And the use of micro-fragmented adipose tissue may benefit for improving symptoms of knee osteoarthritis accompanied by atherosclerosis although may lead to some mild adverse events. Randomized controlled trials with long-term follow-up are necessary for further evaluation because many limitations of this meta-analysis cannot be ignored.
Is serotonin transporter brain binding associated with the cortisol awakening response? An independent non-replication
Authors: Conradi Juliane , E. Svensson Jonas , V. Larsen Søren , Frokjaer Vibe G. 
Published: August 2023

Background
Serotonergic brain signaling is considered critical for an appropriate and dynamic adaptation to stress, seemingly through modulating limbic system functions, such as the hypothalamic-pituitary-adrenal (HPA)-axis. This interplay is of great interest since it holds promise as a target for preventing stress-related brain disorders, e.g., major depression. Our group has previously observed that prefrontal serotonin transporter (5-HTT) binding, imaged with positron emission tomography (PET), is positively associated with the cortisol awakening response (CAR), an index of HPA axis stress hormone dynamics. The aim of this cross-sectional study was to replicate the previous finding in a larger independent group of healthy individuals.

Methods
Molecular imaging and cortisol data were available for 90 healthy individuals. Prefrontal 5-HTT binding was imaged with [11C]DASB brain PET. Non-displaceable 5-HTT binding potential (BPND) was quantified using the Multilinear Reference Tissue Model 2 (MRTM2) with cerebellum as the reference region. CAR was based on five serial salivary cortisol samples within the first hour upon awakening. The association between CAR and prefrontal 5-HTT BPND was evaluated using a multiple linear regression model adjusted for age and sex. Further, we tested for sex differences in the association. Finally, an exploratory analysis of the association, was performed in 8 additional brain regions.

Results
We observed no statistically significant association between 5-HTT binding and CAR corrected for age and sex in the prefrontal cortex (β = -0.28, p = 0.26). We saw no interaction with sex on the association (p = 0.99).

Conclusion
We could not confirm a positive association between CAR and prefrontal 5-HTT BPND in this independent dataset. Also, sex differences in the association were not apparent. Our data do not exclude that the serotonin transporter system is involved in the regulation of stress responses in at-risk or manifest depressed states.
Novel Ultra-Fast Liquid Chromatography Method for Simultaneous Quantification of Metformin Hydrochloride and Remogliflozin Etabonate
Authors: PANCHAL J , Dhalani J. 
Published: August 2023

An advanced formulation having remogliflozin etabonate (REM) and metformin hydrochloride (MET) for the treatment of diabetes was recently approved. However, there hasn't been any information reported on a UFLC technique for simultaneously quantifying both active substances. Therefore, aim of the study was the development of an ultra-fast isocratic liquid chromatography method for quantification of MET and REM in API and dosage form. The reversed phase-UFLC method was developed with a very short run time of only 3 min with no interference due to blank. The compounds were separated using Shimadzu Sim-pack XR ODS (75 mm × 3 mm, 2.2 μ) column with mobile phase consisting of buffer (0.1% phosphoric acid):acetonitrile (30:70). The developed method was validated as per ICH-Q2(R1). The linearity was established in the range of 0.01-125 ppm and 0.01-25 ppm for MET and REM, respectively. The average assay was found 99.4% for MET and 99.1% for REM. The accuracy was observed 98.29-99.49% for MET and 98.39-99.73% for REM. The proposed method is very fast and simple however precise and accurate. This method is very useful for regular quality control laboratory to quantify MET and REM in API and dosages forms.
Electronic Spectroscopy and Molecular Modelling Study of Supramolecular Receptors based on Azo Compound of o-Toluidine Capable of Sensing Mercuric Ion
Authors: DAS RIDIP , SARMA RAJIB LOCHAN , KALITA DIPJYOTI 
Published: August 2023

Two supramolecular receptors capable of binding anion as well as metal ion were synthesized by linking o-toluidine with 2,6-diaminopyridine and 4-aminopyridine via diazocoupling reaction. The interaction of the receptors with different acids and metal ions were studied in solution state by using UV-visible titration. One of the receptors is capable of sensing Hg2+ ion in solution state by showing considerable amount of bathochromic shift in its absorption maxima. Their binding affinities were also compared by calculating binding constants from the UV-visible titration data. A theoretical study was carried simultaneously to investigate the plausible interaction of host-guest complexes. The different binding affinities were calculated from the free energy change data and compared with the experimental values. The possible structure of metal complexes of Hg2+, Cu2+ and Fe2+ ions were optimized and their properties were also studied. The limit of detection (LoD) of Hg2+ ions was found to be 0.223 ppm.
Investigation of Relationship between Playing the Piano Capability and the Second-to-Fourth Digit (2D:4D) Ratio
Authors: Ayşe Gül Kabakci  , Memduha Gülhal Bozkir  
Published: August 2023

BACKGROUND
In the field of piano playing, the suitability of physical characteristics of individuals, especially at the beginner level, is one of the first criteria considered important for educators. In many studies examining the physical fitness of individuals in sports fields, the importance of the relationship between physical fitness and ability has been revealed. In addition, there are studies examining the physical fitness for playing any instrument in the field of music. However, studies examining the physical characteristics of beginner piano players are very limited. Therefore, the purpose of our study was to investigate the relationship between the physical properties of the hand and the ability to play the piano. In addition, our study is the first to examine the relationship between the second digit and fourth digit ratio and the state of being successful in playing the piano. We also intended to contribute to the literature on this subject.
METHODS
Among the students who participated in the ballet and piano special talent exam held at Cukurova University State Conservatory in the 2013 and 2015 academic years, students who participated in the piano special talent exam were included in the study. In this exam, the suitability of the candidate to play the piano was evaluated in terms of musical and physical competence. In our study, the second digit and fourth digit length parameters, which include the physical characteristics of the hand, were evaluated. Length measurements were made with a digital display caliper. Students between the ages of 8 and 11 who participated in the piano talent exam were divided into two groups as those who were successful and those who were unsuccessful in the talent test.
RESULTS
The number of successful girls was 20 and the average length of the second digit 6.00±0.50 cm, mean fourth digit length; 5.90±0.40 cm, the number of unsuccessful girls was 17, the average of the second length; 5.98±0.48 cm, and the mean fourth digit length was 5.89±0.48 cm. The number of successful men was 15, and the mean length of the second digit; 6.55±0.36 cm, mean fourth digit length; 6.61±0.47 cm, the number of unsuccessful men was 17, the mean length of the second digit; 6.46±0.52 cm, mean fourth digit length; 6.52±0.55 cm were found.
CONCLUSIONS
There was no significant relationship between the piano playing ability and the second digit and fourth digit length ratios. We think that this is due to the evaluation of factors such as the level of development of the sensorimotor and neuromuscular system, the level of auditory proficiency, and coordination, not only with the anatomical suitability factors, in the scoring of the talent exam. Therefore, we can say that being successful in playing the piano does not depend only on digit lengths.
Iliac Artery–Inferior Vena Cava–Duodenal Fistula: An Unusual Cause of Massive Gastrointestinal Bleeding
Authors: Karna Rahul , Jagdish Balaji , Mohy-Ud-Din Nabeeha , Kulkarni Abhijit 
Published: August 2023

ABSTRACT
An arteriovenous-enteric fistula is a 3-way connection between the vascular and enteric system and associated with high mortality. We describe a case of iliac artery–inferior vena cava–duodenal fistula in a young female with a retroperitoneal mass presenting with sepsis and hemorrhagic shock with a catastrophic clinical course. These fistulas can be missed on endoscopy/colonoscopy and are usually diagnosed on computed tomography angiogram of the abdomen. Complex vasculoenteric fistula should be among differentials in patients presenting with gastrointestinal bleeding, especially with a history of malignancy, radiation, foreign bodies, and trauma. The management is complex and should involve a multidisciplinary approach involving vascular surgery, intervention radiology, and gastroenterologist.
Methodological weaknesses regarding the use of PEF-meters when assessing physiological effects of air pollution risk factors
Authors: Golja Petra 
Published: August 2023

The manuscript discusses the applicability of self-administered monitoring of respiratory function in asthma patients in order to discern between negative health effects of different air pollutants on respiratory function. Thirteen asthma patients measured their respiratory function twice daily over a one month winter period. They used PEF-meters to monitor peak expiratory flow (PEF;L/min) and forced expiratory volume in the first second of expiration (FEV1; L). Subjects’ vital capacity (VC; L) was measured in a laboratory setting at the end of the measuring period. Respiratory data were evaluated in respect to the ambient concentrations of NO2, NOx, SO2, O3, and PM10, which were monitored during the same period. The concentrations of some air pollutants (PM10 and NOx) exceeded the critical levels on several days during the study. PEF-meter data (PEF, FEV1 and FEV1/VC), however, did not respond significantly to the ambient conditions (P>0.05). The results speak against the use of self-administered PEF-meter monitoring for the recognition and investigation of air pollutant related negative health effects. Limitations and delimitations of the method are presented.