bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐VEGF and steroid combination therapy relative to anti‐VEGF mono therapy for the treatment of refractory DME: A systematic review of efficacy and meta‐analysis of safety
Authors: Hatamnejad Amin , Orr Samantha , Dadak Rohan , Khanani Arshad , Singh Rishi , Choudhry Netan 
Published: June 2023

AbstractThe aim of the study was to determine the efficacy and safety of combined anti‐VEGF and steroid therapy in treatment refractory DME patients. We conducted a systematic review and meta‐analysis of peer‐reviewed articles reporting on visual, anatomical and adverse outcomes to compare the efficacy and safety of combined intravitreal anti‐VEGF/steroids versus anti‐VEGF monotherapy for refractory DME. Seven studies (4 RCTs and 3 observational studies) reporting on 452 eyes were included. Our systematic review showed that combination therapy is significantly more effective for anatomical outcomes in the treatment of resistant DME compared to anti‐VEGF monotherapy in six studies. Two studies found that addition of intravitreal steroids promoted faster visual improvement, but not significantly better final visual outcomes compared to anti‐VEGF monotherapy. Combination therapy was associated with a higher incidence of IOP‐related adverse events (RR = 0.10, 95% CI = [0.02, 0.42], p = 0.002) and cataract‐related adverse events (RR = 0.10, 95% CI = [0.01, 0.71], p = 0.02). Our systematic review and meta‐analysis of seven studies and 452 eyes revealed that combination therapy of anti‐VEGF and steroid intravitreal drugs in the management of treatment refractory DME resulted in superior anatomical outcomes in all but one study. Combination therapy led to superior short‐term visual outcomes in two studies, while others reported no difference between treatment groups. Meta‐analysis revealed that combination therapy was associated with more adverse events. Future research should provide guidance on the standard definitions for treatment resistance and therapeutic alternatives for DME patients with sub‐optimal response to anti‐VEGF treatment.
Process and Pitfalls of Online Teaching and Learning with Design Study “Lite” Methodology: A Retrospective Analysis
Authors: Syeda Uzma Haque , Dunne Cody , Borkin Michelle A. 
Published: June 2023

AbstractDesign studies are an integral method of visualization research with hundreds of instances in the literature. Although taught as a theory, the practical implementation of design studies is often excluded from visualization pedagogy due to the lengthy time commitments associated with such studies. Recent research has addressed this challenge and developed an expedited design study framework, the Design Study “Lite” Methodology (DSLM), which can implement design studies with novice students within just 14 weeks. The framework was developed and evaluated based on five semesters of in‐person data visualization courses with 30 students or less and was implemented in conjunction with Service‐Learning (S‐L). With the growth and popularity of the data visualization field—and the teaching environment created by the COVID‐19 pandemic—more academic institutions are offering visualization courses online. Therefore, in this paper, we strengthen and validate the epistemological foundations of the DSLM framework by testing its (1) adaptability to online learning environments and conditions and (2) scalability to larger classes with up to 57 students. We present two online implementations of the DSLM framework, with and without Service‐Learning (S‐L), to test the adaptability and scalability of the framework. We further demonstrate that the framework can be applied effectively without the S‐L component. We reflect on our experience with the online DSLM implementations and contribute a detailed retrospective analysis using thematic analysis and grounded theory methods to draw valuable recommendations and guidelines for future applications of the framework. This work verifies that DSLM can be used successfully in online classes to teach design study methodology. Finally, we contribute novel additions to the DSLM framework to further enhance it for teaching and learning design studies in the classroom. The preprint and supplementary materials for this paper can be found at https://osf.io/6bjx5/.
FlexEvent: going beyond Case‐Centric Exploration and Analysis of Multivariate Event Sequences
Authors: van der Linden S. , Wulterkens B.M. , van Gilst M.M. , Overeem S. , van Pul C. , Vilanova A. , van den Elzen S. 
Published: June 2023

AbstractIn many domains, multivariate event sequence data is collected focused around an entity (the case). Typically, each event has multiple attributes, for example, in healthcare a patient has events such as hospitalization, medication, and surgery. In addition to the multivariate events, also the case (a specific attribute, e.g., patient) has associated multivariate data (e.g., age, gender, weight). Current work typically only visualizes one attribute per event (label) in the event sequences. As a consequence, events can only be explored from a predefined case‐centric perspective. However, to find complex relations from multiple perspectives (e.g., from different case definitions, such as doctor), users also need an event‐ and attribute‐centric perspective. In addition, support is needed to effortlessly switch between and within perspectives. To support such a rich exploration, we present FlexEvent: an exploration and analysis method that enables investigation beyond a fixed case‐centric perspective. Based on an adaptation of existing visualization techniques, such as scatterplots and juxtaposed small multiples, we enable flexible switching between different perspectives to explore the multivariate event sequence data needed to answer multi‐perspective hypotheses. We evaluated FlexEvent with three domain experts in two use cases with sleep disorder and neonatal ICU data that show our method facilitates experts in exploring and analyzing real‐world multivariate sequence data from different perspectives.
Beyond Alternative Text and tables: Comparative Analysis of Visualization Tools and Accessibility Methods
Authors: Kim N. W. , Ataguba G. , Joyner S. C. , Zhao Chuangdian , Im Hyejin 
Published: June 2023

AbstractModern visualization software and programming libraries have made data visualization construction easier for everyone. However, the extent of accessibility design they support for blind and low‐vision people is relatively unknown. It is also unclear how they can improve chart content accessibility beyond conventional alternative text and data tables. To address these issues, we examined the current accessibility features in popular visualization tools, revealing limited support for the standard accessibility methods and scarce support for chart content exploration. Next, we investigate two promising accessibility approaches that provide off‐the‐shelf solutions for chart content accessibility: structured navigation and conversational interaction. We present a comparative evaluation study and discuss what to consider when incorporating them into visualization tools.
State‐of‐the‐Art Report on Optimizing Particle Advection Performance
Authors: Yenpure A. , Sane S. , Binyahib R. , Pugmire D. , Garth C. , Childs H. 
Published: June 2023

AbstractThe computational work to perform particle advection‐based flow visualization techniques varies based on many factors, including number of particles, duration, and mesh type. In many cases, the total work is significant, and total execution time (“performance”) is a critical issue. This state‐of‐the‐art report considers existing optimizations for particle advection, using two high‐level categories: algorithmic optimizations and hardware efficiency. The sub‐categories for algorithmic optimizations include solvers, cell locators, I/O efficiency, and precomputation, while the sub‐categories for hardware efficiency all involve parallelism: shared‐memory, distributed‐memory, and hybrid. Finally, this STAR concludes by identifying current gaps in our understanding of particle advection performance and its optimizations.
VA + Embeddings STAR: A State‐of‐the‐Art Report on the Use of Embeddings in Visual Analytics
Authors: Huang Z. , Witschard D. , Kucher K. , Kerren A. 
Published: June 2023

AbstractOver the past years, an increasing number of publications in information visualization, especially within the field of visual analytics, have mentioned the term “embedding” when describing the computational approach. Within this context, embeddings are usually (relatively) low‐dimensional, distributed representations of various data types (such as texts or graphs), and since they have proven to be extremely useful for a variety of data analysis tasks across various disciplines and fields, they have become widely used. Existing visualization approaches aim to either support exploration and interpretation of the embedding space through visual representation and interaction, or aim to use embeddings as part of the computational pipeline for addressing downstream analytical tasks. To the best of our knowledge, this is the first survey that takes a detailed look at embedding methods through the lens of visual analytics, and the purpose of our survey article is to provide a systematic overview of the state of the art within the emerging field of embedding visualization. We design a categorization scheme for our approach, analyze the current research frontier based on peer‐reviewed publications, and discuss existing trends, challenges, and potential research directions for using embeddings in the context of visual analytics. Furthermore, we provide an interactive survey browser for the collected and categorized survey data, which currently includes 122 entries that appeared between 2007 and 2023.
Navigating precarity in everyday (sub)urban space in Helsinki, Finland
Authors: Jaatsi Mia , Kymäläinen Päivi 
Published: June 2023

AbstractThis article addresses the everyday forms of urban precarity, which is under‐studied in the context of Finnish cities. We examine how urban precarity becomes lived, practiced, and resisted in the case of a suburban open‐air shopping center in Helsinki, Finland. Referring to precarity as a socio‐spatial condition that reveals the precariousness of urban people and places, this study discovered everyday forms of urban precarity in detailed materialities and tactics; in housing, food, and addiction struggles; and in movements and networks. These mundane manifestations revealed that precarity could be approached in more relative terms that are not linked with certain neighborhoods but that emerge as spaces with intersecting nodes of services, networks, mobilities, and sociality. We conclude that particular places across urban spaces, where these aspects intersect, can be central to the ways precarity is navigated in the city and to increasing understandings of the mechanisms through which spaces of precarity are constructed in the city. The methodological choices used in this article—volunteer ethnography and vignettes—present profound accounts of the microscale lived experience, and bring humanness to a context that often exhibits stereotypes and marginality.
Nietzsche and “we knowers”: Comments on Reginster's The Will to Nothingness
Authors: Kirwin Claire 
Published: June 2023

AbstractNietzsche's On the Genealogy of Morality is strikingly book‐ended by the theme of knowledge‐seeking: the Preface opens with the ominous claim that “[w]e are unknown to ourselves, we knowers”, and the Third Essay's climax is the assertion that scientific, scholarly activity does not stand in opposition to the ascetic ideal but is instead only that ideal's most recent and insidious instantiation. This feature of the text is absent from Reginster's The Will to Nothingness. Nonetheless, the interpretive machinery that Reginster develops in his reading of the Genealogy as a genealogy and critique of morality can also go a long way towards helping us to make sense of the text as, at the same time, a genealogy and critique of knowledge‐seeking. Making use of Reginster's account in this way serves to illuminate both the interpretive power and some of the limitations of his reading.
Individual diet specialization in the spider Tidarren haemorrhoidale (Bertkau, 1880) (Theridiidae)
Authors: Moura Rafael Rios , Pêgo Priscila Teixeira , Sobczak Jober F. , Gonzaga Marcelo Oliveira 
Published: June 2023

AbstractIndividual specialization (IS) in resource use is common within populations of several animal species because some individuals can be more efficient than others in obtaining specific food items. Spiders are usually classified as euryphagous predators, but the broad diet of populations may result from many individuals specializing in capturing different types of prey. Empirical evidence supporting this pattern, however, is still scarce. In this study, we hypothesized that (1) the diet of individuals of Tidarren haemorrhoidale is more restricted than the population's diet and (2) individual diet restrictions are not determined by the spatial distribution of prey types. We collected the prey remains of 74 webs of females in a conservation area of the Atlantic Forest. Our results indicated that T. haemorrhoidale could be considered a euryphagous predator because its diet comprised Opiliones, Diplopoda, and eight orders of insects. However, spiders exhibited moderate and high degrees of IS for prey size and taxa, respectively. There was no modularity for both prey attributes in the food web, but there was a medium nestedness. Most individuals captured ants, but additional prey taxa were of different orders. There was no correlation between the dissimilarity of prey taxa and the distances between the webs, suggesting that IS did not occur based on the spatial distribution of their potential prey. The diversity of prey defensive strategies may induce spiders to perform specific behavioral routines after prey interception. If this occurs, cognitive constraints may limit their ability to use different capture routines efficiently. Our study supports the predictions of individual niche specialization theory for a euryphagous spider species and highlights the potential of spiders as a study model to investigate the underlying mechanisms.
Structure elucidation and characterization of patulin synthase, insights into the formation of a fungal mycotoxin
Authors: Tjallinks Gwen , Boverio Alessandro , Maric Ivana , Rozeboom Henriette , Arentshorst Mark , Visser Jaap , Ram Arthur F. J. , Mattevi Andrea , Fraaije Marco W. 
Published: June 2023

Patulin synthase (PatE) from Penicillium expansum is a flavin‐dependent enzyme that catalyses the last step in the biosynthesis of the mycotoxin patulin. This secondary metabolite is often present in fruit and fruit‐derived products, causing postharvest losses. The patE gene was expressed in Aspergillus niger allowing purification and characterization of PatE. This confirmed that PatE is active not only on the proposed patulin precursor ascladiol but also on several aromatic alcohols including 5‐hydroxymethylfurfural. By elucidating its crystal structure, details on its catalytic mechanism were revealed. Several aspects of the active site architecture are reminiscent of that of fungal aryl‐alcohol oxidases. Yet, PatE is most efficient with ascladiol as substrate confirming its dedicated role in biosynthesis of patulin.
Pathological features associated with metastasis in patients with early invasive (pT1) colorectal carcinoma in colorectal polyps
Authors: Brown Ian , Zammit Andrew P , Bettington Mark , Cooper Caroline , Gill Anthony J , Agoston Agoston , Odze Robert 
Published: June 2023

AimsColorectal carcinoma (CRC) arising in a colorectal polyp with invasion limited to the submucosa is sufficiently treated by complete endoscopic resection alone in many cases. Histological features of the carcinoma including tumour size, vascular invasion and poor tumour differentiation or evidence of de‐differentiation, such as tumour budding, are associated with a higher risk for metastasis such that oncological resection is recommended. However, most malignant polyps with these features do not have lymph node metastases at the time of resection, so there is a need for better refinement of the histological risk features.Methods and resultsA total of 437 consecutive colorectal polyps with submucosal invasive carcinoma from a single centre, 57 of which had metastatic disease, were supplemented by 30 cases with known metastatic disease from two additional centres. Clinical and histological features of the polyp cancers were reviewed looking for differences between the 87 cancers with metastatic disease and the remaining cases without metastasis. A subgroup of 204 polyps removed intact was also analysed to ensure maximum histological accuracy.ConclusionsThis study confirmed larger invasive tumour size, vascular invasion and poor tumour differentiation as adverse predictive features. Prominent peritumoral desmoplasia and high cytological grade were additional adverse features. A predictive logistic regression model comprised of (i) presence of any form of vascular invasion; (ii) presence of high tumour budding (BD3); (iii) width of invasive tumour component > 8 mm; (iv) depth of invasive tumour > 1.5 mm; and (v) the finding of prominent expansile desmoplasia located within and beyond the deep invasive edge of the carcinoma, showed excellent performance in predicting metastatic disease.
Inhibition of gingival fibroblast necroptosis mediated by RIPK3/MLKL attenuates periodontitis
Authors: Zhang Kaiying , Chen Xiaoxin , Zhou Rong , Chen Zhao , Wu Buling , Qiu Wei , Fang Fuchun 
Published: June 2023

AbstractAimNecroptosis participates in the pathogenesis of many inflammatory diseases, including periodontitis. Here, we aimed to investigate the role and mechanism of necroptosis inhibitors in attenuating periodontitis.Materials and MethodsThe Gene Expression Omnibus (GEO) dataset GSE164241 was re‐analysed to identify the role of necroptosis in periodontitis. Gingival specimens from healthy subjects or periodontitis patients were collected to evaluate the expression level of necroptosis‐associated proteins. The therapeutic effect of necroptosis inhibitors on periodontitis was assessed in vivo and in vitro. Moreover, Transwell assays and Western blotting and siRNA transfection were used to identify the effects of necroptotic human gingival fibroblasts (hGFs) on THP‐1 macrophages.ResultsRe‐analysis revealed that gingival fibroblasts (GFs) in periodontitis gingiva showed the highest area under the curve score of necroptosis. Elevated levels of necroptosis‐associated proteins were identified in GFs in periodontitis gingiva collected from patients and mice. In ligature‐induced periodontitis mice, local administration of receptor interacting protein kinase 3(RIPK3) inhibitor GSK′872 or sh‐mixed‐lineage kinase domain‐like pseudokinase (Mlkl) markedly abrogated necroptosis and rescued periodontitis. Analogously, necroptosis inhibitors alleviated the inflammatory response and release of damage‐associated molecular patterns in lipopolysaccharide‐ or LAZ (LPS + AZD'5582 + z‐VAD‐fmk, necroptosis inducer)‐induced GFs and then reduced THP‐1 cell migration and M1 polarization.ConclusionsNecroptosis in GFs aggravated gingival inflammation and alveolar bone loss. Necroptosis inhibitors attenuate this process by modulating THP‐1 macrophage migration and polarization. This study offers novel insights into the pathogenesis and potential therapeutic targets of periodontitis.
Do Southeast Asia's paleo‐Antarctic trees cool the planet?
Authors: Wilf Peter , Kooyman Robert M. 
Published: June 2023

SummaryMany tree genera in the Malesian uplands have Southern Hemisphere origins, often supported by austral fossil records. Weathering the vast bedrock exposures in the everwet Malesian tropics may have consumed sufficient atmospheric CO2 to contribute significantly to global cooling over the past 15 Myr. However, there has been no discussion of how the distinctive regional tree assemblages may have enhanced weathering and contributed to this process. We postulate that Gondwanan‐sourced tree lineages that can dominate higher‐elevation forests played an overlooked role in the Neogene CO2 drawdown that led to the Ice Ages and the current, now‐precarious climate state. Moreover, several historically abundant conifers in Araucariaceae and Podocarpaceae are likely to have made an outsized contribution through soil acidification that increases weathering. If the widespread destruction of Malesian lowland forests continues to spread into the uplands, the losses will threaten unique austral plant assemblages and, if our hypothesis is correct, a carbon sequestration engine that could contribute to cooler planetary conditions far into the future. Immediate effects include the spread of heat islands, significant losses of biomass carbon and forest‐dependent biodiversity, erosion of watershed values, and the destruction of tens of millions of years of evolutionary history.
New social relations of digital technology and the future of work: Beyond technological determinism
Authors: Joyce Simon , Umney Charles , Whittaker Xanthe , Stuart Mark 
Published: June 2023

AbstractThis introduction sets out the context for the Special Issue and offers an in‐depth reflection on key themes addressed by our contributors. The Special Issue aims to place the social relations of production at the centre of debates about technology and the future of work, and create space for greater critical reflection on what it means to go ‘beyond technological determinism’. We identify ways in which aspects of technological determinism continue to influence debates on technology, the labour process and industrial relations, despite efforts to reject it. We argue that this influence is manifested in some persistent problems within the literature including overly rigid periodisations (such as ‘platform capitalism’), a narrow conceptual repertoire (which reifies notions like ‘algorithmic control’) and a constricted empirical focus. We elucidate the value of a social shaping of technology (SST) approach to overcome these challenges and provide a brief overview of the articles contained within the issue.