bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial vampirism mediated through taxis to serum
Authors: Glenn Siena J. , Gentry-Lear Zealon , Shavlik Michael , Harms Michael J. , Asaki Thomas J. , Baylink Arden 
Published: July 2023

AbstractBacteria of the family Enterobacteriaceae are associated with gastrointestinal (GI) bleeding and bacteremia and are a leading cause of death, from sepsis, for individuals with inflammatory bowel diseases. The bacterial behaviors and mechanisms underlying why these bacteria are prone to bloodstream entry remains poorly understood. Herein, we report that clinical isolates of non-typhoidalSalmonella entericaserovars,Escherichia coli, andCitrobacter koseriare rapidly attracted toward sources of human serum. To simulate GI bleeding, we utilized a custom injection-based microfluidics device and found that femtoliter volumes of human serum are sufficient to induce the bacterial population to swim toward and aggregate at the serum source. This response is orchestrated through chemotaxis, and a major chemical cue driving chemoattraction is L-serine, an amino acid abundant in serum that is recognized through direct binding by the chemoreceptor Tsr. We report the first crystal structures ofSalmonellaTyphimurium Tsr in complex with L-serine and identify a conserved amino acid recognition motif for L-serine shared among Tsr orthologues. By mapping the phylogenetic distribution of this chemoreceptor we found Tsr to be widely conserved among Enterobacteriaceae and numerous World Health Organization priority pathogens associated with bloodstream infections. Lastly, we find that Enterobacteriaceae use human serum as a source of nutrients for growth and that chemotaxis and the chemoreceptor Tsr provides a competitive advantage for migration into enterohaemorrhagic lesions. We term this bacterial behavior of taxis toward serum, colonization of hemorrhagic lesions, and the consumption of serum nutrients, as “bacterial vampirism” which may relate to the proclivity of Enterobacteriaceae for bloodstream infections.
Proteomics and phosphoproteomics profiling in glutamatergic neurons and microglia in an iPSC model of Jansen de Vries Syndrome
Authors: Aguilan Jennifer T. , Pedrosa Erika , Dolstra Hedwig , Baykara Refia Nur , Barnes Jesse , Zhang Jinghang , Sidoli Simone , Lachman Herbert M. 
Published: July 2023

BackgroundJansen de Vries Syndrome (JdVS) is a rare neurodevelopmental disorder (NDD) caused by gain-of-function (GOF) truncating mutations inPPM1Dexons 5 or 6. PPM1D is a serine/threonine phosphatase that plays an important role in the DNA damage response (DDR) by negatively regulating TP53 (P53). JdVS-associated mutations lead to the formation of a truncated PPM1D protein that retains catalytic activity and has a GOF effect because of reduced degradation. SomaticPPM1Dexons 5 and 6 truncating mutations are well-established factors in a number of cancers, due to excessive dephosphorylation and reduced function of P53 and other substrates involved in DDR. Children with JdVS have a variety of neurodevelopmental, psychiatric, and physical problems. In addition, a small fraction has acute neuropsychiatric decompensation apparently triggered by infection or severe non-infectious environmental stress factors.MethodsTo understand the molecular basis of JdVS, we developed an induced pluripotent stem cell (iPSC) model system. iPSCs heterozygous for the truncating variant (PPM1D+/tr), were made from a patient, and control lines engineered using CRISPR-Cas9 gene editing. Proteomics and phosphoprotemics analyses were carried out on iPSC-derived glutamatergic neurons and microglia from three control and threePPM1D+/triPSC lines. We also analyzed the effect of the TLR4 agonist, lipopolysaccharide, to understand how activation of the innate immune system in microglia could account for acute behavioral decompensation.ResultsOne of the major findings was the downregulation of POGZ in unstimulated microglia. Since loss-of-function variants in thePOGZgene are well-known causes of autism spectrum disorder, the decrease inPPM1D+/trmicroglia suggests this plays a role in the neurodevelopmental aspects of JdVS. In addition, neurons, baseline, and LPS-stimulated microglia show marked alterations in the expression of several E3 ubiquitin ligases, most notably UBR4, and regulators of innate immunity, chromatin structure, ErbB signaling, and splicing. In addition, pathway analysis points to overlap with neurodegenerative disorders.LimitationsOwing to the cost and labor-intensive nature of iPSC research, the sample size was small.ConclusionsOur findings provide insight into the molecular basis of JdVS and can be extrapolated to understand neuropsychiatric decompensation that occurs in subgroups of patients with ASD and other NDDs.
The association between different types of dietary fat intake and blood lipids in Type 2 diabetes patients: sex differences
Authors: Al-Mssallem Muneera Qassim , Alarifi Sehad Nasser , Al-Mssallem Nora Ibrahim 
Published: July 2023

Purpose Blood lipid and lipoprotein abnormalities are common among patients with diabetes. The study aimed to assess dietary fat intake and its association with blood lipids among patients with Type 2 diabetes mellitus (T2DM) considering sex differences.Design/methodology/approach A cross-sectional observational study was conducted with patients (207 males and 197 females) with T2DM. The daily food intake and its contents of fat and fat types were assessed through face-to-face interview. Anthropometric measurements, glycated hemoglobin (HbA1c), triglyceride, total cholesterol (TC), high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were initially recorded.Findings The results revealed that TC, LDL and HDL cholesterol levels were significantly higher in females than in males. However, the TC: HDL ratio was significantly higher in males than in females. The results also showed that the daily intake of saturated fatty acid (SFA) slightly exceeded the daily recommended allowance. However, the monounsaturated fatty acid + polyunsaturated fatty acid/SFA (MUFA + PUFA/SFA) ratio was within the recommended ratio. In addition, this study found that the main sources of SFA and cholesterol intake were milk and milk products. A significant association between high fat intake and HbA1c levels was observed (r = 0.234, p < 0.001).Research limitations/implications As it is a cross-sectional observational study, this study has the natural limitation where it can only demonstrate an association.Originality/value The types of dietary fat intake may contribute to blood lipid abnormalities and differences effects may exist among male and female. Studies on the effect of daily fat intake and its types on blood lipids in patients with diabetes, in particular Saudi patients with diabetes are limited. This study focused on the amount and type of the consumed fat among male and female Saudi patients with T2DM and studied the relationship between the type of consumed fat and blood lipid profiles.
Institutional ownership and board governance. A structured literature review on the heterogeneous monitoring role of institutional investors
Authors: Velte Patrick 
Published: July 2023

Purpose
This paper aims to review empirical research on the relationship between institutional ownership (IO) and board governance (85 studies).

Design/methodology/approach
Based on agency and upper echelons theory, the heterogeneous monitoring function of specific types and the nature of institutional investors on board composition, compensation and chief executive officer (CEO) characteristics will be focused.

Findings
The author found that most studies have referred to archival studies, analyzed the impact of board governance on IO, focused on CEO characteristics, neglected IO heterogeneity and advanced regression models to address endogeneity concerns. In line with the theoretical framework, the relationship between total IO and board governance is heterogeneous. However, specific types such as foreign, dedicated and pressure-resistant institutions represent active monitoring tools and push for increased board governance.

Research limitations/implications
The author provided useful recommendations for future research from a content and methodological perspective, e.g. the need for analyzing the impact of IO on sustainable board governance and other characteristics of top management team members, e.g. the chief financial officer.

Practical implications
As many regulatory bodies implemented regulations to promote shareholder rights and board governance, this literature review highlights the connections of both corporate governance mechanisms. Managers should conduct a careful and timely investor analysis and change the composition and compensation of the board of directors in line with institutional investors’ preferences.

Originality/value
This analysis makes useful contributions to prior research by focusing on IO and board governance, whereas the author structured the heterogeneous variables and results within the structured literature review. The authors guides researchers, regulatory bodies and business practice in this corporate governance topic.
“It worked for my friend”: non-medical use of tramadol among manual labourers in Anambra state, Nigeria
Authors: Nwafor Chidozie Edwin , Okoye Chukwuemeka Felix A. , Nwankwo Nelson I. , Ugwu Paschal Chukwuma 
Published: July 2023

Purpose
This study aims to explore the dynamics involved in the non-medical use of tramadol among manual labourers in Nigeria.

Design/methodology/approach
Using the phenomenological approach, we conducted in-depth interviews with forty (40) manual labourers (age: 19–36 years). These participants were selected through purposive and snowball sampling techniques from two cities in Anambra state, Nigeria, and the data was analysed with thematic analysis.

Findings
The results revealed that most of the participants were introduced to tramadol use by their friends. They used tramadol for pain relief, euphoric feeling, energy for work and sexual performance. Unfortunately, most of them may have gradually become dependent on this drug to function well in life without knowing the possible medical and psychological implications.

Research limitations/implications
The sample choice may limit the generalization of the findings; however, the study indicates a need to improve working condition, access to healthcare and awareness of the negative effects of non-medical use of tramadol.

Originality/value
Non-medical use of tramadol may have started as an attempt to help self in performing the daily routine. This action can jeopardize an individual’s mental health and, at the extreme state, hinder performance of daily routine. Friends and the quality of information they provide play a significant role in the onset of this action. The strong point is that many people who are involved in the non-medical use of tramadol are unaware of the possible risks. Improving working conditions and access to healthcare for chronic pain could help reduce these risks.
Trust in disaster resilience
Authors: Fornalé Elisa , Armiero Marco , Odasso Laura 
Published: July 2023

PurposeThe erosion of ‘trust’ (among citizens as well as within and between institutional levels) is a worrying aspect of these turbulent times in Europe and beyond. Trust (between citizens and institutions, citizens and experts, policymakers and experts, and among different levels of governance) is crucial in all dimensions of disaster resilience. Risk perceptions stem from a complex web of feedback between individuals, communities, institutions, and experts. Sometimes, institutions and experts are slow or even resistant to accepting signals and knowledge about risks coming from the grassroots. Or, it is the other way around, and citizens are skeptical about the information coming from institutions and experts. Thus, trust must work in all directions (from citizens to institutions, from experts to citizens, etc.) to build a cooperative framework for action.Design/methodology/approachOur article aims to explore the construction of trust and distrust in communities dealing with historical, actual, or potential disasters by putting forward a three-dimensional approach (societal, cooperative, and institutional). We convey the idea that less tangible aspects such as culture, contextual history, knowledge, and habits shape the perception of risk, the degree of preparedness and, ultimately, the impacts of environmental changes.FindingsThese elements affect cooperative behaviors, and it is expected that the institutional environment – which will vary across domestic, national, and regional contexts – will play a significant role in nurturing trust or distrust in relation to disaster risk.Originality/valueThis article will offer valuable insights by developing a new conceptual framework that can be translated and validated by future research.
A new method for solving multiple definite integrals using multiple sets of correlation extreme learning machines
Authors: Li Shangjie , Huang Xianzhen , Wang Xingang , Zhao Chengying , Lv Hangyuan 
Published: July 2023

PurposeThis paper aims to develop a novel method and apply it to solve multiple definite integrals. The proposed method is constructed based on multiple sets of correlation extreme learning machines (MCELM).Design/methodology/approachThe authors present a novel method for solving multiple definite integrals. By using an extreme learning machine (ELM) to learn the integrand function, the primitive function is analytically derived based on the functional expression of the trained ELM and expressed by another ELM, while the correlations between the two ELMs are established. Solutions of multiple definite integrals can be realized by applying this process repeatedly.FindingsTo verify the validity and effectiveness of the proposed method, various examples are selected and its numerical solutions are obtained by using the proposed method. The proposed method has high computational accuracy and efficiency, and the superiority is illustrated by comparing with some other existing methods.Originality/valueMCELM method is proposed for solving multiple definite integrals. The method can be applied for solving multiple definite integrals appearing in applications, the strong applicability of the method in engineering problems is demonstrated in structural system reliability analysis of a cantilever beam.
Construction group conflict under resource overlap: a game theory approach
Authors: Peng Junlong , Zhang Qi 
Published: July 2023

PurposeThe replenishment of construction materials heavily relies on the functioning of heavy machinery, which often leads to confusion and negotiations among construction work groups regarding the allocation rights of these materials. When multiple groups require the same construction materials, they often struggle to determine whether the delivered materials are intended for their own use or if they have encroached upon supplies designated for others. Such uncertainties and negotiations frequently result in delays in construction progress and have the potential to escalate into conflicts. To minimize misunderstandings among work groups and mitigate the risk of severe safety consequences, it is crucial to understand the decision-making processes involved in the interaction between work groups.Design/methodology/approachThis paper adopts a game theory approach to examine the interactions among work groups from a safety perspective. Quantum response equilibrium (QRE), as a specialized form of game with incomplete information, is assumed to govern the behavior of work groups in this study. By conducting a questionnaire survey, interactive scenarios were simulated. A resource overlap scenario for high-altitude construction is established, with the key factors being the importance of construction materials, the time required to supplement materials, whether managers are present and the climate within the groups. The model parameters were estimated using the expectation–maximization algorithm. Additionally, individual traits and safety awareness are surveyed in the questionnaire, further explaining the results of the game.FindingsThe findings indicate that the likelihood of conflicts between work groups under resource overlap can be quantified. The radical behavior of construction work groups exhibits a positive correlation with the importance of construction materials and the time required for material replenishment. Furthermore, the presence of a safety climate and the oversight of management personnel play a significant role in maintaining the composure of construction work groups. The expanded results of the questionnaire demonstrate that there is considerable room for improvement in workers' safety awareness, and management approaches can be further enhanced to prevent unsafe behaviors from occurring.Originality/valueA novel game theory model was developed to evaluate the behavior of construction groups in situations of resource overlap. This model offers practical suggestions to improve safety performance and efficiency in construction projects.
Consumer anticipation as a performative experience
Authors: Vichiengior Tunyaporn , Ackermann Claire-Lise , Palmer Adrian 
Published: July 2023

Purpose
The purpose of this study is to explore consumer anticipation processes that occur after commitment to a purchase has been made, but before consumption occurs. The authors add to the knowledge and theory building about anticipation that occurs in this liminal phase by investigating the cognitive, emotional and behavioural processes that interact to influence post-consumption evaluations.

Design/methodology/approach
An abductive research approach used a phase-based research design using semi-structured interviews. The authors identify interactions between cognitive, emotional and behavioural processes that occur during anticipation and associate these with post-consumption outcomes.

Findings
Anticipation of a consumption experience, enacted through thoughts, emotions and actions, and undertaken with peers, is an experience per se, independent from and interdependent with the substantive experience, and contributes to performance of the substantive experience. The authors propose a framework in which anticipation – as a performative phenomenon – influences the overall evaluations of the substantive consumption experience in contexts of delayed consumption. The theoretical grounding of performativity makes a useful contribution through its linkage of thought processes to outcomes. The authors further locate their findings within the literature on attribution theory. By engaging in anticipation, informants perceived the locus of causality to be internal, and expressed pride in having anticipated if the subsequent experience was successful. By anticipating, informants perceived an ability to exert control over future events and felt ashamed of not having adequately anticipated if an experience was subsequently unsuccessful.

Research limitations/implications
The theoretical grounding of performativity makes a useful contribution through its linkage of thought processes to outcomes. The authors further locate their findings within the literature on attribution theory. By engaging in anticipation, informants perceived the locus of causality to be internal and expressed pride in having anticipated if the subsequent experience was successful. By anticipating, informants perceived an ability to exert control over future events and felt ashamed of not having adequately anticipated if an experience was subsequently unsuccessful.

Practical implications
The authors discuss the trade-off service providers face between encouraging anticipation, which raises expectations that might not be met, and facilitating anticipatory preparations, which may reduce the risk of service failure.

Originality/value
The authors provide a new lens by conceptualising anticipation as a performative process and identifying mechanisms by which anticipation is embedded in total consumption experience. This study has important generalisable implications for contexts where mechanisms of performative anticipation may be a means for ameliorating uncertainty about future consumption experiences.
The innovative–performance connection: how dynamic capabilities empower nurses
Authors: Alwali Joather 
Published: July 2023

Purpose
This paper aims to examine the relationship between employee dynamic capabilities (EDCs), innovative work behavior (IWB) and job performance (JP) among nurses in public hospitals in Iraq. It also determines the mediating role of IWB in the relationship between EDC and JP.

Design/methodology/approach
This study uses structural equation modeling via partial least squares (PLS-SEM) and bootstrapping estimation to analyze the model. A total of 425 respondents participated in the survey, though only 372 participants completed all the items in the questionnaire. Hence, 372 responses were analyzed after data screening.

Findings
This study indicates that EDC has a positive correlation with IWB among nurses in public hospitals in Iraq. It also shows that IWB has a positive relationship with JP. It further demonstrates that IWB has a positive mediating effect on the relationship between EDC and JP among nurses in Iraq’s public hospitals.

Research limitations/implications
The implication of this study is that EDC can significantly predict IWB, while the latter is a significant predictor of JP among nurses in public hospitals in Iraq. Besides, the relationship between EDC and JP is significantly mediated by IWB. However, as a cross-sectional investigation showing a single snapshot in time, this study has some limitations in terms of establishing strict causality among the variables. Rather than extensive actual data, the findings are based on a log compiled by a key respondent. The findings are obtained from a survey conducted in one country, but certain variables, such as EDC, may have varying implications across different countries. Hence, future research can focus on a diverse range of countries, which could be used to ascertain the findings’ generalizability.

Originality/value
This study advances our understanding of the direct effect of the exploration and exploitation variables as well as the mediating effect of IWB in the relationship between EDC and JP among nurses in public hospitals in Iraq.