bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial
Authors: Sardari Masihi Lilit , Borumandnia Nasrin , Taheri Maryam , Basiri Abbas , Imani Hossein , Jalali Saba , Tavasoli Sanaz 
Published: July 2023

Abstract
Objectives
To evaluate the effects of two vitamin D repletion therapies (cholecalciferol) on serum levels of 25-hydroxyvitamin D (25(OH)D) and 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency (VDD).

Design, setting, participants
A parallel-group randomized controlled clinical trial on patients who referred to Labbafinejad kidney stone prevention clinic, Tehran, Iran. From 88 recurrent calcium stone formers, 62 patients completed the study. The age of participants was 18–70 years who had serum 25(OH)D levels of 10–20 ng/ml.

Intervention
Participants received oral cholecalciferol 2000 IU daily for 12 weeks or 50,000 IU weekly for 8 weeks.

Main outcome measures
Study variables including 24-h urine calcium, supersaturations of calcium oxalate and calcium phosphate, serum 25(OH)D and parathyroid hormone were measured at the beginning of the study and after 12 weeks.

Results
The 24-h urine calcium significantly increased in both groups (β = 69.70, p < 0.001), with no significant difference between treatments. Both groups showed no significant change in the supersaturation levels of calcium oxalate and calcium phosphate. Serum levels of 25(OH)D increased significantly (β = 12.53, p < 0.001), with more increase in the 50,000 IU group (β = 3.46, p = 0.003). Serum parathyroid hormone decreased in both groups (p < 0.001).

Conclusions
Although both treatment protocols increased 24-h urine calcium, they did not increase the supersaturation state of calcium oxalate or calcium phosphate.
Trial registration IRCT20160206026406N4, 13/08/2019.
Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis
Authors: Lloyd Grace M. , Long Brooke , Quintin Stephan , Sorrentino Zachary A. , Gorion Kimberly-Marie M. , Bell Brach M. , Carrillo Denise , Sullivan Patrick , Borchelt David , Giasson Benoit I. 
Published: July 2023

AbstractPost-translational modifications to the carboxyl (C) terminus domain of α-synuclein can play an important role in promoting the pathologic aggregation of α-synuclein. Various cleavages that diminish this highly charged, proline-rich region can result in exposure of hydrophobic, aggregation-prone regions, thereby accelerating the aggregation kinetics of α-synuclein into misfolded, pathologic forms. C-terminally truncated forms of α-synuclein are abundant in human diseased brains compared to controls, suggesting a role in disease pathogenesis. Factors that alter the homeostatic proteolytic processing of α-synuclein may ultimately tip the balance towards a progressive disease state. Apolipoprotein E (APOE) has been implicated in the acceleration of cognitive impairment in patients with Lewy body diseases. The APOE4 isoform has been found to cause dysregulation in the endosomal–lysosomal pathway, which could result in altered α-synuclein degradation as a potential mechanism for promoting its pathologic misfolding. Herein, we investigate the spatiotemporal accumulation of C-terminally truncated α-synuclein in a seeded and progressive mouse model of synucleinopathy. Furthermore, we study how this process is influenced in the context of mice that are altered to express either the human APOE3 or APOE4 isoforms. We found that specific C-terminal truncation of α-synuclein occurs at early stages of pathogenesis. We also found that proteolytic processing of this domain differs across various brain regions and is influenced by the presence of different human APOE isoforms. Our data demonstrate an early pathogenic role for C-terminally truncated α-synuclein, and highlight the influence of APOE isoforms in modulating its impact.
Platform-independent and curriculum-oriented intelligent assistant for higher education
Authors: Sajja Ramteja , Sermet Yusuf , Cwiertny David , Demir Ibrahim 
Published: July 2023

AbstractMiscommunication between instructors and students is a significant obstacle to post-secondary learning. Students may skip office hours due to insecurities or scheduling conflicts, which can lead to missed opportunities for questions. To support self-paced learning and encourage creative thinking skills, academic institutions must redefine their approach to education by offering flexible educational pathways that recognize continuous learning. To this end, we developed an AI-augmented intelligent educational assistance framework based on a powerful language model (i.e., GPT-3) that automatically generates course-specific intelligent assistants regardless of discipline or academic level. The virtual intelligent teaching assistant (TA) system, which is at the core of our framework, serves as a voice-enabled helper capable of answering a wide range of course-specific questions, from curriculum to logistics and course policies. By providing students with easy access to this information, the virtual TA can help to improve engagement and reduce barriers to learning. At the same time, it can also help to reduce the logistical workload for instructors and TAs, freeing up their time to focus on other aspects of teaching and supporting students. Its GPT-3-based knowledge discovery component and the generalized system architecture are presented accompanied by a methodical evaluation of the system’s accuracy and performance.
Nicolau syndrome with pemphigus vulgaris: a rare case report and review of literature
Authors: Avvaru Deepthi , Patil Soumya , Doshi Bhavana , Wali Shashikala 
Published: July 2023

Abstract
Background
Nicolau syndrome is a rare adverse drug reaction clinically presented with painful erythema and tissue necrosis often accompanied by intramuscular injections of NSAIDS (diclofenac), penicillin, corticosteroids and local anesthetics.

Case presentation
This case report describes a 29-year-old male patient who was repeatedly hospitalized for the treatment of recalcitrant pemphigus vulgaris. When the patient visited for the fourth time to our hospital, he complained of unusual sharp pain over the right gluteal region ever since the administration of diclofenac 75 mg intramuscular injection for persistent back pain during his previous stay. On physical examination, the right gluteal region showed a globular swelling with erythema and pus filled necrosed tissue. The CT scan did not show any presence of hematoma, ruling out any possibility of compartment syndrome. Based on this clinical evidence he was diagnosed with Nicolau Syndrome secondary to diclofenac injection. The tissue injury necessitated surgical debridement and after a span of 2 months, it healed leaving a permanent scar. In addition, this case report highlights the treatment of recalcitrant pemphigus vulgaris with rituximab therapy.

Conclusion
Clinical pharmacist plays a vital role in educating healthcare professionals about following right protocol for administration of injectable drugs, early detection and management of the ADR. Similarly, patient receiving injections should be educated about warning signs and symptoms of such adverse drug reaction.
Green synthesis of silver nanoparticles and degradation of AZO-dyes using Cestrum diurnum plant extract, and antimicrobial activities of AgNP’s.
Authors: Ahmad Kamil , Warsito Budi , Wasiq Jafron , Khan Saqib , Ahmed Naseer , Calvin Eagu John , Ashraf Maria 
Published: July 2023

Nanoparticles play an important role now days in different fields like drug delivery, diagnostics, therapy, engineering, energy, healthcare and Environment. The goal of this study was to synthesize Silver Nanoparticles from extract of C. dirnum plant, degradation of azo-dyes with synthesized AgNP’s and finding bioactivity of AgNP’s against bacteria’s. The UV-Visible analysis of solution after addition of AgNP’s showed that the addition of silver NP’s reduced the absorbance peak of methyl orange from 2.87 to 1.0 and absorbance peak of methyl red decreased from 2.92 to 1.75. Green synthesis concepts can be used to create metal nano-particles, which have a promising future in the Azo-dye breakdown process. C. diurnum leaf extract acts as a reducing agent to synthesize metal nano-particles, providing environmentally friendly and energy-efficient alternatives. Bioactivity of AgNP's against gram negative and gram-positive bacteria were tested which gave strong inhibition against bacteria.
Age(ism) in Hans Christian Andersen’s fairy tales
Authors: Fürholzer Katharina 
Published: July 2023

Abstract
Across the globe, the genre of the fairy tale is inextricably linked with Hans Christian Andersen (1805–1875). To this day, the Danish writer and his sombre, often dystopian tales are famed for their pronounced criticism of socio-cultural norms and are read and loved by all ages. In his work, Andersen made ample use of the fantastic, which ranges from the realm of the supernatural (esp. anthropomorphic plants, animals, and things) to the realm of the (realistically) imaginary such as the faculty of imagination or (religious) beliefs. In doing so, socio-cultural phenomena such as conceptions of and reactions to (older) age are approached from a broad spectrum of angles. While research has already shown a keen interest in matters of gender, (homo)sexuality, and class in Andersen’s tales, his approach to (older) age and ageism has rather been ignored so far. Against this backdrop, this paper aims to break ground in the form of an in-depth analysis of correlations between age(ism) and the fantastic in Andersen’s literary tales “Grandmother” (1845) and “The Old House” (1847), with a particular interest in the question of how far age(ism) is constructed by both the narrator and the reader.
“It made her age hard to guess”: Narrating the dynamics of aging and gender through Victorian Gothic archetypes in Susan Hill’sThe Woman in Black
Authors: Miquel-Baldellou Marta 
Published: July 2023

AbstractAlthough Susan Hill has become a prolific writer of ghost narratives in the last decades, it was at a particularly momentous stage of her life as a woman writer that she publishedThe Woman in Black(1983), which is considered her first ghost novel. Evoking the Victorian past,The Woman in Blackengages intertextually with Victorian novels within the Gothic genre. The character of the Woman in Black comprises features pertaining to different Victorian Gothic archetypes, such as the ghost, the vampire, and the double. Some of the traits pertaining to these literary archetypes echoed Victorian anxieties about aging that are recovered and reinterpreted in Hill’s novel. Furthermore, in analogy with a Gothic romance, the encounter between the narrator as a young man, Arthur Kipps, and a spectral aging woman, the Woman in Black, unleashes the hero’s process of coming of age, which he recollects in his old age as he is writing his narrative. Narratological features pertaining to the Gothic genre, like the use of a frame narrative that blends past and present, underscore the dynamics of aging, since processes of interrupted aging and premature aging disrupt the boundaries that conventionally distinguish life stages. This article approaches Hill’sThe Woman in Blackas a contemporary ghost novel that evokes and subverts Victorian discourses of aging and gender, at the same time that, from a contemporary perspective, it vindicates the figure of the Victorian fallen woman as an aging mother.
Futurity, the life course and aging in Kazuo Ishiguro’s Klara and the Sun
Authors: Sako Katsura , Falcus Sarah 
Published: July 2023

Abstract
Reading Kazuo Ishiguro’s Klara and the Sun (2021) in this article, we bring the perspectives of aging and posthumanist studies together to explore how the novel helps us to rethink our being and relationality in time beyond the boundaries of the human. In particular, we are interested in the novel’s critique of the anthropocentric privileging of youth and progress in the ways in which we imagine the future. Central to this form of imagination are generational continuity and the symbolism of the child: a new generation as a promise of the future, or rather, a better human future. Nevertheless, this novel does not simply employ the trope of generational futurity; instead, it interrogates and draws attention to the exclusionary way this type of thinking functions. Through its blurring of human and AI “child”, ultimately, Klara and the Sun suggests the dangers and the limits of a generational imagination that seeks to reproduce the same, progressive narrative of the future through the image of the child not “growing up and growing old” (Woodward 2020: 55; italics in original). Our analysis then suggests how fictional speculative modes might both engage with and yet also force us to reflect critically upon that form of future-orientated thinking.
Design optimization of a supersonic through-flow fan rotor based on the blade profiles
Authors: Yang Jutao , Ji Lucheng , Shen Yuxin , Zhou Ling 
Published: July 2023

Abstract
In this study, the authors propose an optimization process to design the baseline rotor of a supersonic through-flow fan (STFF) at an inlet Mach number of 2.0 based on Genetic Algorithm. Unlike the improvement in performance brought about by the pre-compression of conventional supersonic profiles in the presence of axial pressure flow, pre-compression did not help improve the performance of the rotor of the STFF. The efficiency of elements of the blade at spanwise heights of 10 %, 50 %, and 90 % increased by 2.47 %, 1.95 %, and 2.49 %, respectively. The performance of the rotor of the STFF that was reconstructed by stacking the optimized elements of the blade was improved at the design point as well as in off-design conditions by using three-dimensional computational fluid dynamics (CFD) simulations. The performance of the blade also improved considerably, with increases of by 2.46 % and 9.59 % in its isentropic efficiency and the overall pressure ratio, respectively.
Les négociations commerciales entre le Mercosur et le Canada : processus et enjeux
Authors: Rodrigues Barreto Junior Edison , Paquin Stéphane 
Published: July 2023

Depuis 2018, le Canada et les pays du Mercosur négocient un accord de commerce de nouvelle génération. Cette négociation commerciale n’est pas sans défis. En effet, il s’agit d’une négociation entre une fédération (le Canada) et un regroupement de pays (Mercosur), dont deux fédérations, qui ont leurs propres logiques de négociation. Les relations commerciales bilatérales entre le Canada et les pays du Mercosur sont modestes. Les exportations canadiennes totalisaient 2,3 milliards de dollars contre 6,6 milliards pour les exportations des pays du Mercosur. Dans le cas du Canada, il est loin d’être certain que les agriculteurs sous gestion de l’offre en matière agricole, tout comme plusieurs premiers ministres provinciaux, accepteront des concessions en matière agricole pour un meilleur accès au marché des pays du Mercosur. Du côté du Mercosur, c’est le secteur industriel, notamment au Brésil et en Argentine, qui a tendance à résister aux concessions. Contrairement au Canada, l’intérêt stratégique de l’ensemble des pays du bloc converge vers l’ouverture du marché agricole. L’objectif de cet article est d’exposer de manière comparée les intérêts des pays du Mercosur, avec un accent sur le Brésil, et du Canada dans le cadre de ces négociations commerciales. Il cherche également à décrire comment se déroulent les négociations afin de mieux comprendre la dynamique en place
Régine Robin (1939-2021) e a incontornável escrita da sobrevida
Authors: Duarte Kelley Baptista 
Published: July 2023

Entre celebrações e despedidas, este artigo propõe somar-se às inúmeras homenagens, realizadas nos últimos meses, à Régine Robin, escritora nascida na França, mas que escolheu o Quebec como lugar de produção e inspiração intelectuais. O objetivo, aqui, é seguir um itinerário de vida e de produção para destacar o texto robiniano como espaço de sobrevida na convergência dos temas identidade, memória e biografia.
Apetrecho para Desenho de Instrumentos Líticos Lascados
Authors: Fernandes Henry Luydy Abraham , Veiga Luis Felipe de Medeiros , Rodet Maria Jaqueline 
Published: July 2023

Resumo:O presente artigo trata de um equipamento desenvolvido durante o estágio pós-doutoral em 2018 no Laboratório de Tecnologia Lítica do Museu de História Natural e Jardim Botânico da UFMG. Consiste de um aparato simples, mecânico, facilmente produzido e de baixo custo, cujo objetivo é tornar mais rápidos e precisos os desenhos de peças líticas lascadas. Descrevemos as tentativas com baseem diversos equipamentos preexistentes que levaram à criação e aperfeiçoamento da ideia. Por fim, apresentamos o último protótipo finalizado e testado, seu funcionamento e suas características, de modo que os pesquisadores interessados possam fabricar um modelo e dele se valer nas suas investigações e desenhos. Abstract:This article deals with equipment developed during the post-doctoral internship in 2018 at the Laboratory of Lithic Technology of the Museum of Natural History and Botanical Garden of UFMG. It consists of a simple, mechanical apparatus, easily produced and of low cost, whose objective is to make the drawings of flaked lithic pieces faster and more accurate. We describe the attempts based on various preexisting equipment that led to the creation and improvement of the idea. Finally, we present the last finalized and tested prototype, its operation and its characteristics so that interested researchers can manufacture a model and use it in their investigations and drawings.
Fronteira cultural ou disputa pela paisagem? O caso da sinagoga de Tel Dor, Israel
Authors: Rodrigues Marques de Oliveira Gabriela 
Published: July 2023

Através de informações contidas na obra de Josefo e em relatórios de escavações em Tel Dor, tomamos conhecimento de um episódio que ocorreu nessa cidade em 42 d.C., quando um grupo de romanos depositou uma estátua do imperador dentro de uma sinagoga. Tal ato foi desrespeitoso não apenas com os judeus, mas com o próprio imperador, que havia garantido liberdade de culto aos mesmos. A partir desse acontecimento, discutiremos questões concernentes aos usos do culto imperial nas províncias romanas, e às fronteiras e limites existentes entre Roma e os romanos das províncias, e entre judeus e romanos. Trataremos também de como essas fronteiras podem ser simbólicas e culturais, mas ainda sim levar a uma disputa pela paisagem construída. Abstract: Through information contained in the work of Josephus and excavations reports of Tel Dor, we came to know of a possible episode that occurred in that city in 42 C.E., when a group of Romans deposited an imperial statue inside a synagogue. The existence of material remains of the synagogue and the statue was not yet proved, but if such an act did happened it was disrespectful not only to the Jews, but to the emperor himself, who had guaranteed religious freedomship for them. From that event, even if it was not proven factual, we will discuss issues concerning the uses of imperial cult in the roman provinces, and the borders and boundaries existing between Rome and the Romans of the provinces, and between Jews and Romans. We will also deal with how these borders can be symbolic and cultural, but at same time lead to a dispute over the built landscape.
Bioarqueologia do Indivíduo Exumado do Sítio Cucuíra – Ponta de Pedras, Pará, Brasil
Authors: Cunha Claudia Minervina Souza , Veiga Wagner Fernando , Silva Anna Bárbara , Silva Felipe Damasceno e 
Published: July 2023

Resumo:O Sítio Cucuíra, localizado em Ponta de Pedras (Pará, Brasil) produziu um contexto funerário culturalmente associável à ocupação Marajoara da Ilha que é aqui analisado nos aspectos paleobiológicos e funerários. Neste contexto parte dos ossos de um indivíduo robusto adulto foram inumados em enterramento secundário em urna cerâmica. Ao lado da urna e em alinhamento com 4 vasilhas votivas, foi depositado um crânio humano com mandíbula em conexão anatômica. Esta disposição não encontra paralelo nos contextos funerários Marajoara, podendo remeter a outras possibilidades interpretativas sobre a pertença (ou não) do crânio ao indivíduo inumado na urna e à possível objetificação deste em posição sinonímica em relação aos objetos votivos. A análise dos remanescentes humanos evidencia condições patológicas no indivíduo, particularmente no que diz respeito a um processo infeccioso no osso mandibular. Abstract: This study addresses a funerary context associated to the Marajoara culture which was exhumed from the archaeological site of Cucuíra located in Ponta de Pedras (Pará). Part of the skeleton of a robust adult individual were buried in a ceramic pot as a secondary deposition. Next to the funerary urn for ceramic vases and a human skull articulated with a compatible mandible were deposited. The literature on Marajoara funerary contexts does not register a similar pattern of deposition and it raises the question of the relationship between the skull and post cranial bones as well as the possible objetification of the skull placed in similar position to the votive objects of the funerary pack. The analysis of the human remains has evidenced pathological conditions mainly concerning oral health.
Myocastor coypus: su explotación durante el Holoceno tardío en el sudeste uruguayo.
Authors: Moreno Federica 
Published: July 2023

La presencia de Myocastor coypus es recurrente en los sitios prehistóricos del sudeste uruguayo. En este trabajo se presentan los resultados del análisis zooarqueológico de los restos de M. coypus recuperados en un montículo del sitio Ch2D01 (Holoceno tardío). La nutria representa el 1,6% del total (NISP=306) y se estimó un NMI=35. Utilizando la escala de Rusconi para determinación de edad, se encontró que el 88,7% de las mandíbulas corresponden a animales adultos. No se encontró una correlación significativa entre %MAU y los valores de densidad ósea de Marmota sp., lo que muestra que pueden descartarse problemas de equifinalidad. Las modificaciones antrópicas y naturales son escasas, lo que puede deberse, en parte, a las precipitaciones calcáreas, que dificultan la observación de las superficies. Este análisis muestra que la nutria se utilizó como fuente de alimento y materias primas durante todo el período de ocupación del sitio, y existió una selección hacia individuos adultos. Abstract:The presence of Myocastor coypus is recurrent in the archaeological sites of southeastern Uruguay, in this paper we present the results of the zooarchaeological analysis of the remains of this taxon recovered in a mound of the Ch2D01 site (2090 ± 90 a 220 ± 50 years BP). The objective is to evaluate the economic importance that this taxon had in this site and the features of its use. To do this, we analyze its relative importance, anatomical abundance and age profile. The integrity of the bone assemblage through the survey of natural and anthropic marks and the correlation between %MAU and bone density. M. coypus represents 1.6% of the total (NISP = 306) with an NMI = 35 and 88.7% of the jaws correspond to adult animals. Anthropic and natural modifications are rare, but it was possible to identify processing marks on the bones. This analysis shows that the otter was used as a source of food and raw materials during the entire period of occupation of the site, and there was a selection towards adult individuals.