bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial Genetic Variants Associated with Bipolar Disorder and Schizophrenia in a Japanese Population
Authors: Tachi Ryobu , Ohi Kazutaka , Nishizawa Daisuke , Soda Midori , Fujikane Daisuke , Hasegawa Junko , Kuramitsu Ayumi , Takai Kentaro , Muto Yukimasa , Sugiyama Shunsuke , Kitaichi Kiyoyuki , Hashimoto Ryota , Ikeda Kazutaka , Shioiri Toshiki 
Published: March 2023

Abstract
Background: Bipolar disorder (BD) and schizophrenia (SZ) are genetic psychotic disorders (PSY) with maternal inheritance. Some studies have investigated whether genetic variants in the mitochondrial chromosome are associated with BD and SZ. However, the genetic variants identified as being associated are not identical among studies, and the participants were limited to individuals of European ancestry. Here, we investigate associations of genome-wide genetic variants in the mitochondrial chromosome with BD, SZ, and PSY in a Japanese population.
Methods: After performing quality control for individuals and genetic variants, we investigated whether mitochondrial genetic variants [minor allele frequency (MAF)>0.01, n=45 variants) are associated with BD, SZ, and PSY in 420 Japanese individuals consisting of patients with BD (n=51), patients with SZ (n=172), and healthy controls (HCs, n=197).
Results: Five mitochondrial genetic variants (rs111033358, rs200165736, rs200478835, rs200044200, and rs28359178), two genetic variants (rs199713564 and rs200478835), and five genetic variants (rs199713564, rs200999343, rs200478835, rs28359178, and rs201250154) appeared to be associated with BD, SZ and PSY, respectively (Puncorr<0.05). Of these variants, three (rs200478835, rs200044200 and rs28359178 on or near NADH dehydrogenase) and one (rs200478835) were significantly associated with BD and PSY, respectively, even after correcting for multiple comparisons (PGC=0.045–4.9×10-3). In particular, individuals with the minor G-allele of rs200044200, a missense variant, were only observed among patients with BD (MAF=0.059) but not HCs (MAF=0) (odds ratio=∞). Three patients commonly had neuropsychiatric family histories.
Conclusions: We suggest that mitochondrial genetic variants in NADH dehydrogenase-related genes may contribute to the pathogenesis of BD and PSY in the Japanese population through dysfunction of energy production.
Investigating the impact of key tumor markers to predict and reduction of lymphoma cancer diagnosis duration with a data mining approach
Authors: Ghorbian Mohsen 
Published: March 2023

Abstract
Various data mining techniques are available today, resulting in different results with varying precisions; therefore, selecting the appropriate methodology can result in a more complete and accurate data analysis. Hence, there are several ways to evaluate the effectiveness of data mining techniques. Choosing the appropriate data mining techniques depends on the type of data on which they will be implemented. When it comes to using data, data in every field has its significance. However, data plays a more significant aspect in specific fields, such as healthcare and data collection for caners. Using data mining techniques to analyze sensitive data like cancers can be challenging if the available information is incomplete, which can significantly impact the results. When working with the information of people with lymphoma cancer, the frequency of factors causing the disease and the lack of information are significant challenges. Lymphoma cancers can be classified as either Hodgkin's disease or non-Hodgkin's disease, which are common cancers. In this research, the criterion for selecting factors tumor markers is the presence of commonality between two types of lymphoma cancer. Five tumor markers, CD3, CD15, CD20, CD30, and LCA, along with the type of lymphoma cancer and the patient's gender, were selected as the variables of this research. Hence, to evaluate two data mining techniques, the Bayesian Networks (Naive Bayes), and the decision tree, we will apply the criteria of accuracy, sensitivity, f-score, and error ratio. However, to determine whether lymphoma cancer diagnosis factors have a positive impact, a 90% confidence interval and a 65% support value have been selected to take into account the highest level of accuracy when determining which factor is effective in diagnosing lymphoma cancer. Based on the implementation of techniques and evaluations, it was determined that the decision tree technique outperformed the Bayesian Networks (Naive Bayes) technique with an accuracy of 82.66%, a sensitivity of 94.98%, a harmonic mean of 85.36%, and an error ratio of 17.33%.Our research also concluded that the presence of CD3 and CD15 positive tumor markers, .also the gender of the individual, do not play a role in the diagnosis of lymphoma cancer. However, CD20 and LCA tumor markers can be effective in diagnosing non-Hodgkin's lymphoma, while CD30 tumor markers can be effective in diagnosing Hodgkin's lymphoma.
Case report：Septic shock after endometrial polypectomy with tissue removal system
Authors: Su Danna , She Jiajie , Li Ying , Guo Yan , Yang Yajie , Tan Qiao , Wang Liping , Diao Ruiying 
Published: March 2023

Abstract
As an emerging surgical technology, tissue removal systems have been widely used in the treatment of endometrial polyps due to its characteristics of less endometrial damage, shorter learning curve and clearer vision of the operative field. There are few cases in the literature reporting serious complications after endometrial polypectomy using tissue removal systems. As known, septic shock is a rare complication following hysteroscopic polypectomy. Now, we present the case of a 23-year-old woman who developed septic shock after polypectomy with tissue removal system. The patient had a history of recurrent vaginitis for more than half a year. Due to EPs, she was admitted to our hospital and scheduled to undergo hysteroscopic endometrial polypectomy. Three hours after the endometrial polypectomy using the tissue removal system, the patient had shock symptoms such as increased body temperature, decreased blood pressure and increased heart rate. Then, the patient was successfully treated and discharged after anti-infection and anti-shock treatments. The purpose of this case report is to remind clinicians to consider the possibility of serious infection and comprehensively evaluate the risk of infection before choosing hysteroscopic devices for EPs, especially for patients who choose the mechanical hysteroscopic tissue removal systems. Furthermore, the mechanical hysteroscopic tissue removal systems should be used with caution in patients with previous recurrent vaginitis.
Comparison of adjuvant nab-paclitaxel plus gemcitabine, S-1 and gemcitabine chemotherapy for resectable pancreatic cancer: a real-world study
Authors: Li Haorui , Guo Yu , Sun Xugang , Lu Yang , Chang Shaofei , Wang Xiuchao , Gao Song , Ma Weidong , Wang Jian , Gao Chuntao , Zhao Tiansuo 
Published: March 2023

Abstract
Purpose
The survival advantages of adjuvant AG (nab-paclitaxel plus gemcitabine) or S-1 chemotherapy compared with GEM (gemcitabine) chemotherapy for resectable pancreatic cancer have been confirmed by the APACT study in 2019 and the JASPAC01 trial in 2016 respectively. However, the evidence about the effectiveness of AG or S-1 in real-world clinical practice is not sufficient.
Methods
Our study included 246 pancreatic cancer patients who underwent surgical treatment and received postoperative adjuvant chemotherapy with AG, S-1, or GEM scheme at Tianjin Medical University Cancer Institute and Hospital from June 2015 to July 2021. The primary outcome was overall survival (OS) and recurrence-free survival (RFS). In general, 246 patients were included, of whom 54(22%) received adjuvant AG, 103(41%) received adjuvant S-1, and 89(37%) received adjuvant GEM.
Results
Adjuvant S-1 was related to a prolonged OS compared to GEM (median OS S-1 vs GEM: 27.0 vs 20.0 months; HR: 0.65, P = .016) and a significantly prolonged RFS compared to GEM (median RFS S-1 vs GEM: 20.0 vs 8.2 months; HR: 0.58, P = .002). After adjusting for known prognostic factors in multivariate Cox regression analysis, this survival benefit persists and is consistent in most subgroups in our subgroup analysis. However, no statistically significant differences in OS or RFS were seen between the patients treated with AG and patients treated with GEM.
Conclusion
To conclude, this real-world study demonstrated that S-1 chemotherapy is associated with superior survival compared to GEM chemotherapy, while the survival advantage of AG chemotherapy compared to GEM chemotherapy remains to be further studied.
Comprehensive characterization of pyroptosis reveals novel molecular typing of biliary atresia as well as contributes to precise treatment
Authors: Li Tengfei , Zheng Qipeng , Wang Xueting , Yang Qianhui , Li Mengdi , Xu Xiaodan , Zhao Yilin , Zhao Fangyuan , Zhang Ruifeng , Wang Zhiru , Sun Rongjuan , Liu Shaowen , Musha Jiayinaxi , Zhang Yanran , Zhan Jianghua 
Published: March 2023

Abstract
Background: Biliary Atresia (BA) is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. Current research has found a variety of causes for BA, with inflammation and fibrosis is more studied. However, these etiological mechanisms are not present in all patients. Pyroptosis has been increasingly appreciated as a programmed cell death process but is less studied in BA. We have re-classified BA by integrating gene microarray data and scRNA-seq data to support individualized clinical treatment and mechanistic studies.
Methods: The BA microarray dataset GSE122340 was downloaded from the Gene Expression Omnibus (GEO) database. GSE46960 and GSE15235 and sequencing data of identical twins as validation cohorts. Through retrospective analysis, 17 differential pyroptosis genes (DEPRGs) were used for typing research. An effective method for identifying BA typing through machine learning algorithms. Subsequently, we performed drug prediction for the pyroptosis subtype to enable individualized treatment. Pyroptosis-score was constructed and combined with scRNA-seq datasets to reveal immune cells and pathways activated during pyroptosis.
Results: Two novel subtypes of pyroptosis were identified. The C1 subtype shows activation of pyroptosis, enhanced inflammatory response, and increased infiltration of monocytes and neutrophils. The C2 subtype exhibits cell cycle activation, low pyroptosis, and a milder inflammatory response. Macrophage pyroptosis may promote the infiltration of more immune cells and the release of inflammatory factors, further aggravating the occurrence of hepatic pyroptosis, which in turn leads to a poorer prognosis in inflammatory BA.
Conclusion: In summary, we have defined two novel subtypes of pyroptosis and offered the possibility of identifying them and individualizing treatment. The role of macrophages, neutrophils, and plasma cells in the pyroptosis process of BA is worthy of further study.
The relationship between learning style and critical thinking based on learning modes
Authors: Yang Luning , Xu Yangting , Hu Yiqun , Wang Lu , Han Yang , Luo Ziqiang 
Published: March 2023

Abstract
Objective: This study is dedicated to uncovering the relationship between critical thinking (CT) and learning styles and the level of each learning mode, as a way of proposing a predictive model of CT that relies on the learning mode.
Methods: In this study, 187 students from Xiangya School of Medicine, Central South University were surveyed between 24 February and 7 March 2022. The questionnaire consisted of three parts: demographic characteristics, the Chinese version of the California Critical Thinking Skills Questionnaire (CTDI-CV) and the Kolb Learning Style Inventory (LSI).
Results: The CTDI-CV total score was positive (293.02±25.66), with the highest scores for inquisitiveness (45.09±6.19) and analyticity (43.70±5.20) and the lowest for self-confidence (39.21±6.22) and systematicity (39.41±5.26) in the seven subscales. On learning styles, there are most Assimilaters (52.9%; 293.89±25.11) and least Convergers (5.9%; 301.66±20.99), with having better CT than Divergers (20.9%; 286.08±27.58) and Accommodaters (20.3%; 279.91±26.26). The differences in CT-related indicators across learning modes were statistically significant (P<0.05), with CE and RO negatively affecting CT(r<0) and AC positively(r>0). Linear regression models for CT scores based on learning modes were constructed.
Conclusion: As a result of our findings, CT and learning modes, the basis of learning styles, were quantified and their relationship was described. These results inform medical education reform, particularly with respect to teaching and assessment systems around improving CT.
Stability of fructooligosaccharides in convectively dried fruits after initial osmoconcentration
Authors: Łuczak Patrycja , Klewicki Robert , Klewicka Elżbieta 
Published: March 2023

Abstract
The aim of this study was to determine the effect of temperature and time of convective drying on the content of fructooligosaccharides (FOS) in apples, plums and strawberries to which FOS had been introduced by osmoconcentration. The share of oligosaccharides in total sugars was analyzed. In apple tissue, fructooligosaccharides were stable in the temperature range 40–80°C during drying for up to 8 h. Convective drying of osmotically dehydrated strawberries caused FOS losses; the FOS retention after 8 hours at 80°C was 40%. In the case of plums, 40% retention was recorded after just two hours at 80°C. Therefore, in the case of some fruits, obtaining a satisfactory level of fructooligosaccharides in the dried material with the assumed level of dry substance requires the determination of appropriate process parameters.
Design of Piezoelectric Transducer for Automobile Seat Belt Locking System
Authors: S Koushik Nimish , Likhitha S 
Published: March 2023

Abstract
The seatbelt locking system is an important part in the automotive electronics domain. Seat belt should get locked when a sudden deceleration takes place. Seatbelt was designed for providing safety for the passengers but in the conventional seatbelt locking system ball and hinge arrangement is used while when the vehicle undergoes sudden deceleration the ball due to its inertia continuous to be in motion, while this movement it makes the hinge to get locked to the gear thus stopping the movement of seatbelt. It had the disadvantage that the seatbelt would lock permanently and detaching the seatbelt was not possible resulting in cutting the webbing, later the seatbelt locking system was designed based on the speed the seatbelt was moving, faster the rate of movement of seatbelt the seatbelt would get locked. Using the battery supply as source the electronic locking mechanism is also been used in locking it. Here in this project we are using a piezoelectric material and an insulating layer to design the seatbelt piezo sensor and use this electrical energy used in locking the seatbelt.
Age and Race/Ethnicity Differences in Decisional Conflict in Women Diagnosed with Ductal Carcinoma In Situ
Authors: Portugal Cecilia , Farias Albert J. , Estrada Erika L. , Kawatkar Aniket A. 
Published: March 2023

Abstract
Purpose:
Women diagnosed with ductal carcinoma in situ (DCIS) face confusion and uncertainty about treatment options. The objective of this study was to determine whether there are differences in decisional conflict about treatment by age and race/ethnicity.
Methods:
A cross-sectional survey was conducted of women (age ≥ 18) diagnosed with DCIS enrolled at Kaiser Permanente of Southern California. The Decisional Conflict Scale (DCS) measured personal perceptions of decision uncertainty, values clarity, and effective decision-making. We used a multivariable regression to study whether age, race, and ethnicity were associated with patient-reported DCS.
Results:
Forty-five percent (N = 1395) of women who received the online survey, participated. The mean age was 56 (± 9.6) years, the majority were white. Compared to women younger than 50, women aged 60–69 reported lower overall DCS scores (-5.4; 95% CI -1.5 to -9.3). Women > 70 had lower values clarity scores (-9.0; 95% CI -2.8 to -15.2) about their treatment compared to women aged 50–59 and 60–69 (-7.1; 95% CI -2.9 to -11.3 and − 7.2; 95% CI -2.9 to -11.5) and likewise, lower effective decision-making scores (-5.4; 95% CI -1.7 to -9.2 and − 5.2; 95% CI -1.4 to -9.0) compared to women < 50. Compared to whites, blacks reported lower decision conflict (-4.4; 95% CI 0.04 to -8.8) and lower informed decision (-5.2; 95% CI -0.18 to -10.3) about DCIS treatment.
Conclusion:
Younger women reported higher decisional conflict about DCIS treatment, compared to older women (> 70). Age based tailored discussions about treatment options, health education, and supportive decision-making interventions/tools may reduce decision conflict in future DCIS patients.
From medical strategy to food-borne prophylactic strategy: stabilizing dental collagen with aloin
Authors: jia Chongzhi , Li Hua , Yang Zhongliang , Xu Rongchen , Wang Lijun , Li Hongbo 
Published: March 2023

Abstract
Objectives: We developed a food-borne prophylactic strategy with aloin to protect dental collagen through enhancing the mechanical strength, thermostability, and the resistance to enzymatic hydrolysis of dental collagen. The mechanism and effect of this food-borne prophylactic strategy were examined.
Methods: Aloin solution (0.1 mg/mL) was prepared. The concentration is equivalent to the natural content of aloin in edible aloe. Attenuated total reflectance flourier transform infrared spectroscopy (ATR-FTIR), Gaussian peak fitting, and X-ray diffraction (XRD) were used to explore the mechanism of interaction between aloin and dental collagen in situ. Mechanical strength and thermostability were separately evaluated via Ultimate tensile strength test (UTS) and thermogravimetric analysis (TGA). Hydroxyproline (HYP), cross-linked carboxy-terminal telopeptide of type I collagen (ICTP), and C-terminal crosslinked telopeptide of type I collagen (CTX) were used as indicators to evaluate the resistance to enzymatic hydrolysis. Wight loss was further tested as macro-parameter to evaluate the effectiveness of aloin on dental collagen stability.
Results: Aloin can interact with dental collagen via hydrogen bonds in humid environment. The interaction shorted the intermolecular distance and enhanced the proportion of stable α-helix chain of dental collagen. Aloin-treated dental collagen exhibited improved mechanical strength, thermostability and enzymatic stability.
Conclusion: Aloin can strongly integrate with dental collagen under physiological conditions via hydrogen bonds and significantly enhance the dental collagen stability.
Clinical Relevance: The use of aloin maybe a daily, nondestructive, and low-cost strategy to protect dental collagen.
A Direct Energy and Force control (DEFC) for switched reluctance motor
Authors: youghourta kassimi 
Published: March 2023

Abstract
The following study is concerned with the controlling and optimization of a switch reluctance machine (SRM) efficiency by a new method proposed for control. The direct force and energy control DEFC, a new method proposed in this work, is based on the direct torque control (DTC), thus in this control, it is directly controlled the energy and the force the simultaneously. This control aims to increase the efficiency of the SR motor and reduce the torque ripple and vibration of the motor. in this work, we applied three methods of control and the proposed method for controlling the switch reluctance motor, including the one that was suggested. in order to prove the efficiency of DEFC we compare the simulation result of it with the result of DEC, DFC, and conventional DTC strategies. We deduced from the findings that the suggested technique DEFC performed better than the other ways and reduced the torque ripple to 10 percent, which enhances the performance of the SRM.
Climate change intensifies the drought vulnerability of river basins: a case of the Magat River Basin
Authors: Felipe Alvin John B. , Alejo Lanie Alejandro , Balderama Orlando F. , Rosete Elmer A. 
Published: March 2023

AbstractThe socioeconomic impact of climate change on the drought vulnerability of a significant agricultural river basin in the Philippines, the Magat River Basin (MRB), was assessed using the AHP-entropy approach and GIS techniques. The different indicators of drought vulnerability dimensions have been evaluated and the results of this study imply that the current drought susceptibility of MRB is at 1.9–3.39 min–max scale or from low to above moderate, where the basin's sensitivity and exposure account for 57 and 31% of the total vulnerability, respectively. And that the resulting adaptive capacity has a mitigating factor of only 12%, thereby construed to be very low. The Santa Fe and Subbasin 2 sub-watersheds are identified to be moderately susceptible to drought with an average rating of 3.1 and 3.25, respectively. Meanwhile, the average drought vulnerability rating of other subbasins is between 2.08 and 2.91, which is from a low to an approximately moderate level. The overall drought susceptibility of the basin is projected to increase due to climate change under future climate scenarios up to 30% (High) of the current level. Catalyzing effective policies and climate change governance are highly encouraged to further improve mitigation and adaptation measures.
Pacientes con enfermedad injerto contra huésped e infecciones asociadas al rechazo de trasplante
Authors: Martínez Jaramillo Sara 
Published: March 2023

Introducción: durante muchos años las células madre hematopoyéticas han sido el tratamiento para muchos trastornos hematológicos, pero su eficacia está limitada por la enfermedad injerto contra huésped (EICH); una de las principales complicaciones del trasplante alogénico se encuentra asociado con morbilidad y mortalidad, por lo tanto, la prevención es importante para el éxito del trasplante alogénico.
Objetivo: realizar una revisión acerca del reconocimiento clínico de una EICH para brindar el tratamiento correcto y evitar ciertas complicaciones, como infecciones que llevan al rechazo del injerto y ponen en riesgo la calidad de vida del paciente. En la mayoría de los casos las pruebas de laboratorio como biomarcadores y biopsias, son buenos predictores para procesos biológicos o patológicos que confirmen el diagnóstico y establezcan el estadio de la enfermedad.
Metodología: se realizó una revisión bibliográfica en bases de datos, tales como Pubmed y ClinicalKey, con base en los siguientes términos MeSH: cirugía, mortalidad, patología, complicaciones, virología.
Conclusión: la prevención y tratamiento de esta enfermedad predispone a infecciones y diferentes complicaciones que ponen en riesgo la vida del paciente.
Сравнительные динамические характеристики конструкционных материалов
Authors: Смирнов Владимир 
Published: March 2023

Работа посвящена изучению динамических характеристик конструкционных материалов, используемых в элементах пролётных строений мостов. Исследуется влияние плотности составов, наличия и типа полых заполнителей, а также наличие фибры на показатели коэффициента механических потерь и динамического модуля упругости. Испытания проводят на стандартных образцах методом экспериментального модального анализа, по результатам которого определяют частоты и формы собственных колебаний и величину коэффициента потерь, соответствующего каждой из собственных форм. Определены величины динамического модуля упругости с использованием аналитического выражения для частоты собственных колебаний шарнирно закреплённой балки.
*Финансирование. Работа выполнена при финансовой поддержке Министерства науки и высшего образования Российской Федерации (Проект: Теоретико-экспериментальное конструирование новых композитных материалов для обеспечения безопасности при эксплуатации зданий и сооружений в условиях техногенных и биогенных угроз. Шифр научной темы FSWG-2020-0007). Работы выполнены на оборудовании Головного регионального центра коллективного пользования научным оборудованием и установками НИУ МГСУ при финансовой поддержке Минобрнауки России (соглашение № 075-15-2021-686).