bluuebunny/crossref_metadata_2025_split huggingface dataset:
NIR Activated Multimodal Therapeutics Based on Metal–Phenolic Networks‐Functionalized Nanoplatform for Combating against Multidrug Resistance and Metastasis
Authors: Cheng Chen , Jiang Weixi , Luo Yuanli , Wan Li , Guo Xun , Xie Zhuoyan , Tang Rui , Huang Tong , Wang Jingxue , Du Chier , Wang Zhigang , Ran Haitao , Li Pan , Zhou Zhiyi , Ren Jianli 
Published: January 2023

AbstractMultidrug resistance (MDR) and metastasis in cancer have become increasingly serious problems since antitumor efficiency is greatly restricted by a single therapeutic modality and the insensitive tumor microenvironment (TME). Herein, metal–phenolic network‐functionalized nanoparticles (t‐P@TFP NPs) are designed to realize multiple therapeutic modalities and reshape the TME from insensitive to sensitive under multimodal imaging monitoring. After a single irradiation, a near‐infrared laser‐activated multistage reaction occurs. t‐P@TFP NPs trigger the phase transition of perfluoropentane (PFP) to release tannic acid (TA)/ferric ion (Fe3+)‐coated paclitaxel (PTX) and cause hyperthermia in the tumor region to efficiently kill cancer cells. Additionally, PTX is released after the disassembly of the TA‐Fe3+ film by the abundant adenosine triphosphate (ATP) in the malignant tumor, which concurrently inhibits ATP‐dependent drug efflux to improve sensitivity to chemotherapeutic agents. Furthermore, hyperthermia‐induced immunogenic cell death (ICD) transforms “cold” tumors into “hot” tumors with the assistance of PD‐1/PD‐L1 blockade to evoke antitumor immunogenicity. This work carefully reveals the mechanisms underlying the abilities of these multifunctional NPs, providing new insights into combating the proliferation and metastasis of multidrug‐resistant tumors.
The Formation Process and Mechanism of Carbon Dots Prepared from Aromatic Compounds as Precursors: A Review
Authors: Xue Shanshan , Li Pengfei , Sun Lu , An Li , Qu Dan , Wang Xiayan , Sun Zaicheng 
Published: January 2023

AbstractFluorescent carbon dots are a novel type of nanomaterial. Due to their excellent optical properties, they have extensive application prospects in many fields. Studying the formation process and fluorescence mechanism of CDs will assist scientists in understanding the synthesis of CDs and guide more profound applications. Due to their conjugated structures, aromatic compounds have been continuously used to synthesize CDs, with emissions ranging from blue to NIR. There is a lack of a systematic summary of the formation process and fluorescence mechanism of aromatic precursors to form CDs. In this review, the formation process of CDs is first categorized into three main classes according to the precursor types of aromatic compounds: amines, phenols, and polycyclics. And then, the fluorescence mechanism of CDs synthesized from aromatic compounds is summarized. The challenges and prospects are proposed in the last section.
Templated Out‐of‐Equilibrium Self‐Assembly of Branched Au Nanoshells
Authors: Marchetti Alessandro , Gori Alessandro , Ferretti Anna Maria , Esteban Daniel Arenas , Bals Sara , Pigliacelli Claudia , Metrangolo Pierangelo 
Published: January 2023

AbstractOut‐of‐equilibrium self‐assembly of metal nanoparticles (NPs) has been devised using different types of strategies and fuels, but achieving finite 3D structures with a controlled morphology through this assembly mode is still rare. Here, a spherical peptide‐gold superstructure (PAuSS) is used as a template to control the out‐of‐equilibrium self‐assembly of Au NPs, obtaining a transient 3D‐branched Au‐nanoshell (BAuNS) stabilized by sodium dodecyl sulphate (SDS). The BAuNS dismantles upon SDS concentration gradient equilibration over time in the sample solution, leading to NPs disassembly and regression to PAuSS. Notably, BAuNS assembly and disassembly promotes temporary interparticle plasmonic coupling, leading to reversible and tunable changes of their plasmonic properties, a highly desirable behavior in the development of optoelectronic nanodevices.
Transition Metal Phosphide Nanoarchitectonics for Versatile Organic Catalysis
Authors: Sharma Devendra , Choudhary Priyanka , Kumar Sahil , Krishnan Venkata 
Published: January 2023

AbstractTransition metal phosphides (TMP) posses unique physiochemical, geometrical, and electronic properties, which can be exploited for different catalytic applications, such as photocatalysis, electrocatalysis, organic catalysis, etc. Among others, the use of TMP for organic catalysis is less explored and still facing many complex challenges, which necessitate the development of sustainable catalytic reaction protocols demonstrating high selectivity and yield of the desired molecules of high significance. In this regard, the controlled synthesis of TMP‐based catalysts and thorough investigations of underlying reaction mechanisms can provide deeper insights toward practical achievement of desired applications. This review aims at providing a comprehensive analysis on the recent advancements in the synthetic strategies for the tailored and tunable engineering of structural, geometrical, and electronic properties of TMP. In addition, their unprecedented catalytic potential toward different organic transformation reactions is succinctly summarized and critically analyzed. Finally, a rational perspective on future opportunities and challenges in the emerging field of organic catalysis is provided. On the account of the recent achievements accomplished in organic synthesis using TMP, it is highly anticipated that the use of TMP combined with advanced innovative technologies and methodologies can pave the way toward large scale realization of organic catalysis.
Cross‐Linked Sodium Alginate as A Multifunctional Binder to Achieve High‐Rate and Long‐Cycle Stability for Sodium‐Ion Batteries
Authors: Mao Zhifei , Wang Rui , He Beibei , Jin Jun , Gong Yansheng , Wang Huanwen 
Published: January 2023

AbstractSodium‐ion batteries (SIBs) hold great promise owing to the naturally abundant sodium resource and high safety. The research focus of SIBs is usually directed toward electrode materials, while the binder as an important component is rarely investigated. Herein, a cross‐linked sodium alginate (SA)/graphene oxide (GO) binder is judiciously designed to serve as a robust artificial interphase on the surface of both anode and cathode of SIBs. Benefiting from the cross‐linking continuous network structure as well as the highly hydrophilic nature, the SA‐GO binder possesses a large tensile strength of 197.7 Mpa and a high ionic conductivity of 0.136 mS cm−1, superior to pure SA (93.8 Mpa, 0.025 mS cm−1). Moreover, the structural design of SA‐GO binder exhibits a strong binding ability to guarantee structural integrity during cycling. To demonstrate its effectiveness, polyanion‐type phosphates (e.g., Na3(VO)2(PO4)2F) and chalcogenides (e.g., MoS2, VS2) are adopted as cathode and anode materials of SIBs, respectively. As compared to traditional binders (e.g., PVDF, SA), electrodes with the SA‐GO binder exhibits significantly increased rate capability and cycling stability, such as Na3(VO)2(PO4)2F (40 C fast‐charge, 84% capacity retention after 1000 cycles). This work highlights the role of novel aqueous‐based binders in developing next‐generation sodium‐storage devices.
Acquiring Bulk Anomalous Photovoltaic Effect in Single Crystals of a Lead‐Free Double Perovskite with Aromatic and Alkali Mixed‐Cations
Authors: Hua Lina , Tang Liwei , Liu Yi , Han Shiguo , Xu Haojie , Guo Wuqian , Ma Yu , Liu Xitao , Luo Junhua , Sun Zhihua 
Published: January 2023

AbstractThe bulk anomalous photovoltaic (BAPV) effect of acentric materials refers to a distinct concept from traditional semiconductor‐based devices, of which the above‐bandgap photovoltage hints at a promise for solar‐energy conversion. However, it is still a challenge to exploit new BAPV‐active systems due to the lacking of knowledge on the structural origin of this concept. BAPV effects in single crystals of a 2D lead‐free double perovskite, (BBA)2CsAgBiBr7 (1, BBA = 4‐bromobenzylammonium), tailored by mixing aromatic and alkali cations in the confined architecture to form electric polarization are acquired here. Strikingly, BAPV effects manifested by above‐bandgap photovoltage (VOC) show unique attributes of directional anisotropy and positive dependence on electrode spacing. The driving source stems from orientations of the polar aromatic spacer and Cs+ ion drift, being different from the known built‐in asymmetry photovoltaic heterojunctions. As the first demonstration of the BAPV effect in the double perovskites, the results will enrich the family of environmentally green BAPV‐active candidates and further facilitate their new optoelectronic application.
Achieving Ultralong‐Cycle Zinc‐Ion Battery via Synergistically Electronic and Structural Regulation of a MnO2 Nanocrystal–Carbon Hybrid Framework
Authors: Xu Xilian , Chen Ye , Li Wanrui , Yin Ruilian , Zheng Dong , Niu Xinxin , Dai Xiaojing , Shi Wenhui , Liu Wenxian , Wu Fangfang , Wu Min , Lu Shengli , Cao Xiehong 
Published: January 2023

AbstractAqueous rechargeable zinc‐ion batteries (ZIBs) have attracted burgeoning interests owing to the prospect in large‐scale and safe energy storage application. Although manganese oxides are one of the typical cathodes of ZIBs, their practical usage is still hindered by poor service life and rate performance. Here, a MnO2–carbon hybrid framework is reported, which is obtained in a reaction between the dimethylimidazole ligand from a rational designed MOF array and potassium permanganate, achieving ultralong‐cycle‐life ZIBs. The unique structural feature of uniform MnO2 nanocrystals which are well‐distributed in the carbon matrix leads to a 90.4% capacity retention after 50 000 cycles. In situ characterization and theoretical calculations verify the co‐ions intercalation with boosted reaction kinetics. The hybridization between MnO2 and carbon endows the hybrid with enhanced electrons/ions transport kinetics and robust structural stability. This work provides a facile strategy to enhance the battery performance of manganese oxide‐based ZIBs.
Metal‐oxo Cluster Mediated Atomic Rh with High Accessibility for Efficient Hydrogen Evolution
Authors: Dong Hai , Zhao Zhenyang , Wu Zihe , Cheng Chong , Luo Xianglin , Li Shuang , Ma Tian 
Published: January 2023

AbstractAchieving single‐atom catalysts (SACs) with high metal content and outstanding performance as well as robust stability is critically needed for clean and sustainable energy. However, most of the synthesized SACs are undesired on the loading content of the metal due to the anchored metals and the supports as well as the synthesizing methods. Herein, a Rh‐SAC with high accessibility by loading it on the metal nodes of metal‐porphyrin‐based PCN MOFs (PCN‐224) as supporting material is reported. Significantly, the PCN‐Rh15.9/KB catalyst with a high Rh content of 15.9 wt% exhibits excellent hydrogen evolution activity with a low overpotential of 25 mV at a current density of 10 mA cm−2 and a mass activity of 7.7 A mg−1Rh at overpotential of 150 mV, which is much better than that of the commercial Rh/C. Various characterizations reveal the Rh species is stabilized by the metal nodes bearing −O/OHx in MOFs, which is of importance for the high loading amount and the good activity. This work establishes an efficient approach to synthesize high content SACs on the nodes of MOFs for wide catalyst design.
Dispersible SnO2:Sb and TiO2 Nanocrystals After Calcination at High Temperature
Authors: Klein Jonas , Philippi Michael , Alarslan Fatih , Jähnichen Tim , Enke Dirk , Steinhart Martin , Haase Markus 
Published: January 2023

AbstractHigh‐temperature treatment of functional nanomaterials, through postsynthesis calcination, often represents an important step to unlock their full potential. However, such calcination steps usually severely limit the preparation of colloidal solutions of the nanoparticles due to the formation of sintered agglomerates. Herein, a simple route is reported to obtain colloidal solutions of calcined n‐conductive antimony doped tin oxide (ATO) as well as titanium dioxide (TiO2) nanoparticles without the need for additional sacrificial materials. This is achieved by making use of the reduced contact between individual nanoparticles when they are assembled into aerogels. Following the calcination of the aerogels at 500 °C, redispersion of the nanoparticles into stable colloidal solutions with various solvents can be achieved. Although a slight degree of sintering is inevitable, the size of the resulting aggregates in solution is still remarkably small with values below 30 nm.
Achieving Ultrahigh Energy‐Density Aqueous Supercapacitors via a Novel Acidic Radical Adsorption Capacity‐Activation Mechanism in Ni(SeO3)/Metal Sulfide Heterostructure
Authors: Song Jinyue , Fan Hongguang , Bai Lichong , Wang Yanpeng , Jin Yongcheng , Liu Shuang , Xie Xiaohui , Zheng Wansu , Liu Wei 
Published: January 2023

AbstractTransitional metal chalcogenide (TMC) is considered as one promising high‐capacity electrode material for asymmetric supercapacitors. More evidence indicates that TMCs have the same charge storage mechanism as hydroxides, but the reason why TMC electrode materials always provide higher capacity is rare to insight. In this work, a NixCoyMnzS/Ni(SeO3) (NCMS/NSeO) heterostructure is prepared on Ni‐plated carbon cloth, validating that both NCMS and NSeO can be transformed into hydroxides in electrochemical process as accompanying with the formation of SeO32‐ and SOx2− in confined spaces of NCMS/NSeO/Ni sandwich structure. Based on density functional theory calculation and experimental results, a novel space‐confined acidic radical adsorption capacity‐activation mechanism is proposed for the first time, which can nicely explain the capacity enhancement of NCMS/NSeO electrode materials. Thanks to the unique capacity enhancement mechanism and stable NCMS/NSeO/Ni sandwich structure, the optimized electrodes exhibit a high capacity of 536 mAh g−1 at 1 A g−1 and the impressive rate capability of 140.5 mAh g−1 at the amazing current density of 200 A g−1. The assembled asymmetric supercapacitor achieves an ultrahigh energy density of 141 Wh Kg−1 and an impressive high‐rate capability and cyclability combination with 124% capacitance retention after 10 000 cycles at a large current density of 50 A g−1.
DNA Nanomaterials‐Based Platforms for Cancer Immunotherapy
Authors: Tian Run , Shang Yingxu , Wang Yiming , Jiang Qiao , Ding Baoquan 
Published: January 2023

AbstractThe past few decades have witnessed the evolving paradigm for cancer therapy from nonspecific cytotoxic agents to selective, mechanism‐based therapeutics, especially immunotherapy. In particular, the integration of nanomaterials with immunotherapy is proven to improve the therapeutic outcome and minimize off‐target toxicity in the treatment. As a novel nanomaterial, DNA‐based self‐assemblies featuring uniform geometries, feasible modifications, programmability, surface addressability, versatility, and intrinsic biocompatibility, are extensively exploited for innovative and effective cancer immunotherapy. In this review, the successful employment of DNA nanoplatforms for cancer immunotherapy, including the delivery of immunogenic cell death inducers, adjuvants and vaccines, immune checkpoint blockers as well as the application in immune cell engineering and adoptive cell therapy is summarized. The remaining challenges and future perspectives regarding the pharmacokinetics/pharmacodynamics, in vivo fate and immunogenicity of DNA materials, and the design of intelligent DNA nanomedicine for individualized cancer immunotherapy are also discussed.
Comparison of traditional and geometric morphometrics using Lake Huron ciscoes of the Coregonus artedi complex
Authors: Martin Benjamin E. , O'Malley Brian , Eshenroder Randy L. , Kao Yu-Chun , Olds Chris M. , O'Brien Timothy P. , Davis Chris L. 
Published: January 2023

Abstract

Objective
Here we determine how traditional morphometrics (TM) compares with geometric morphometrics (GM) in discriminating among morphologies of four forms of ciscoes of the Coregonus artedi complex collected from Lake Huron.

Methods
One of the forms comprised two groups of the same deepwater cisco separated by capture depth, whereas the other three forms were shallow-water ciscoes.

Result
Our three groups of shallow-water ciscoes were better separated (3% vs. 19% overlap) in principle component analysis (PCA) with TM data than with GM data incorporating semilandmarks (evenly spaced nonhomologous landmarks used to bridge between widely separated homologous landmarks). Our two deepwater cisco groups, comprising a putatively single form collected from different depths, separated more in PCAs with GM data (33% overlap) than in PCAs with TM data (66% overlap), an anomaly caused by greater decompression of the swim bladder and deformation of the body wall in the group captured at greater depths. Separation of the two deepwater cisco groups captured at different depths was not affected by the removal of semilandmarks. Assignment of forms using canonical variate analysis accurately assigned 86% of individuals using TM data, 98% of individuals using GM data incorporating semilandmarks, and 100% of individuals using GM data without semilandmarks. However, we considered assignments from the same form of deepwater cisco into separate groups as misassignments resulting from different capture depths, which reduced the accuracy of assignments with GM data incorporating semilandmarks to 66%.

Conclusion
Our study implies that TM will continue to have an important role in morphological discrimination within Coregonus and other fishes similarly shaped.
Genomic selection and genome‐wide association studies in tetraploid chipping potatoes
Authors: Pandey Jeewan , Scheuring Douglas C. , Koym Jeffrey W. , Endelman Jeffrey B. , Vales M. Isabel 
Published: January 2023

AbstractPotato is a major food crop in the United States and around the world. Most potatoes grown in the United States are destined for processing. Genomic selection can speed up breeding progress for important traits, including those with complex inheritance by guiding the identification of the best parents and guiding selection to advance clones in the breeding program. However, the application of genomic selection in polyploid species has been challenging. In this study, we obtained breeding values of 384 chipping clones evaluated in Texas between 2017 and 2020. The mean reliability of the genomic‐estimated breeding values obtained were 0.77, 0.41, 0.61, 0.71, and 0.24 for chip color, chip quality, specific gravity, vine maturity, and total yield, respectively. Potato clones with good chip quality, high yield, high specific gravity, and light‐color chips were identified using a multi‐trait selection index based on weighted standardized genomic‐estimated breeding values. Genome‐wide association studies identified quantitative trait loci on chromosome 5 for vine maturity and chromosomes 1, 3, and 7 for chip color. This research has laid the groundwork for implementing genomic selection in tetraploid potato breeding and understanding the genetic basis of chip processing traits in potatoes.
Genome‐wide diversity analysis suggests divergence among Upper Guinea and the Dahomey Gap populations of the Sisrè berry (Syn: miracle fruit) plant (Synsepalum dulcificum [Schumach. & Thonn.] Daniell) in West Africa
Authors: Tchokponhoué Dèdéou A. , Achigan‐Dako Enoch G. , Sognigbé N'Danikou , Nyadanu Daniel , Hale Iago , Odindo Alfred O. , Sibiya Julia 
Published: January 2023

AbstractAlthough Synsepalum dulcificum is viewed as one of the most economically promising orphan tree crops worldwide, its genetic improvement and sustainable conservation are hindered by a lack of understanding of its evolutionary history and current population structure. Here, we report for the first time the application of genome‐wide single nucleotide polymorphism genotyping to a diverse panel of S. dulcificum accessions to depict the genetic diversity and population structure of the species in the Dahomey Gap (DG) and Upper Guinea (UG) regions to infer its evolutionary history. Our findings suggest low overall genetic diversity but strong population divergence within the species. Neighbor‐joining analysis detected two genetic groups in the UG and DG regions, while STRUCTURE distinguished three genetic groups, corresponding to the UG, Western DG, and Central DG regions. Application of Monmonier's algorithm revealed the existence of a barrier disrupting connectivity between the UG and DG groups. The Western DG group consistently exhibited the highest levels of nucleotide and haplotype diversities, while that of the Central DG exhibited the lowest. Analyses of Tajima's D, Fu's Fs, and Achaz Y* statistics suggest that while both UG and Central DG groups likely experienced recent expansions, the Western DG group is at equilibrium. These findings suggest a geographical structuring of genetic variation which supports the conclusion of differential evolutionary histories among West African groups of S. dulcificum. These results provide foundational insights to guide informed breeding population development and design sustainable conservation strategies for this species.
Functional connectivity and mild behavioral impairment in dementia‐free elderly
Authors: Ghahremani Maryam , Nathan Santhosh , Smith Eric E. , McGirr Alexander , Goodyear Bradley , Ismail Zahinoor 
Published: January 2023

AbstractBackgroundMild behavioral impairment (MBI) is a syndrome that uses later‐life emergent and persistent neuropsychiatric symptoms (NPS) to identify a group at high risk for incident dementia. MBI is associated with neurodegenerative disease markers in advance of syndromic dementia. Functional connectivity (FC) correlates of MBI are understudied and could provide further insights into mechanisms early in the disease course. We used resting‐state functional magnetic resonance imaging (rs‐fMRI) to test the hypothesis that FC within the default mode network (DMN) and salience network (SN) of persons with MBI (MBI+) is reduced, relative to those without (MBI–).MethodsFrom two harmonized dementia‐free cohort studies, using a score of ≥6 on the MBI Checklist to define MBI status, 32 MBI+ and 63 MBI– individuals were identified (mean age: 71.7 years; 54.7% female). Seed‐based connectivity analysis was implemented in each MBI group using the CONN fMRI toolbox (v20.b), with the posterior cingulate cortex (PCC) as the seed region within the DMN and anterior cingulate cortex (ACC) as the seed within the SN. The average time series from the PCC and ACC were used to determine FC with other regions within the DMN (medial prefrontal cortex, lateral inferior parietal cortex) and SN (anterior insula, supramarginal gyrus, rostral prefrontal cortex), respectively. Age, sex, years of education, and Montreal Cognitive Assessment scores were included as model covariates. The false discovery rate approach was used to correct for multiple comparisons, with a p‐value of .05 considered significant.ResultsFor the DMN, MBI+ individuals exhibited reduced FC between the PCC and the medial prefrontal cortex, compared to MBI–. For the SN, MBI+ individuals exhibited reduced FC between the ACC and left anterior insula.ConclusionMBI in dementia‐free older adults is associated with reduced FC in networks known to be disrupted in dementia. Our results complement the evidence linking MBI with Alzheimer's disease biomarkers.Highlights
Resting‐state functional magnetic resonance imaging was completed in 95 dementia‐free persons from FAVR and COMPASS‐ND studies.
Participants were stratified by informant‐rated Mild Behavioral Impairment Checklist (MBI‐C) score, ≥6 for MBI+.
MBI+ participants showed reduced functional connectivity (FC) within the default mode network and salience network.
These FC changes are consistent with those seen in early‐stage Alzheimer's disease.
MBI may help identify persons with early‐stage neurodegenerative disease.