bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRADISI BEJANGO DALAM PERKAWINAN MASYARAKAT SASAK DI DESA SENGKERANG KECAMATAN PRYA TIMUR KABUPATEN LOMBOK TENGAH
Authors: Mustamiin Muhammad Zainal , SAMSUL SAMSUL HADI 
Published: January 2023

Permasalahan dalam penelitian ini adalah: (1) Bagaimanakah pelaksanaan tradisi Bejango. (2) Nilai-nilai apa saja yang terkandung dalam tradisi Bejango. Tujuan penelitian ini adalah (1) Untuk mengetahui pelaksanaan tradisi Bejango dan (2) Untuk mengetahui nilai-nilai yang terkandung pada tradisi bejango. Jenis penelitian ini adalah jenis penelitian kualitatif dengan metode diskriptif. Informan penelitian ini adalah tokoh agama, tokoh adat, tokoh pemuda dan masyarakat. Responden penelitian ini adalah kepala dusun dan kepala desa. Penentuan jumlah informan dan responden dilakukan dengan teknik purposive. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah wawancara, dan observasi. Data dianalisis dengan menggunakan tehnik analsis kualitatif dengan proses reduksi data, penyajian data, dan menarik kesimpulan. Hasil penelitian ini adalah (1) Tradisi bejango sebagai salah satu rangkaian pernikahan dalam adat sasak sekaligus peningalan leluhur/nenek moyang bangsa sasak dilaksanakan melalui tiga tahap yaitu, tahap persiapan, tahap pelaksanaan dan tahap penutup. Kegiatan pada tahap persiapan antara lain penentuan/menyepkati waktu bejango, mengundang tokoh masyarakat dan keluarga terdekat, musyawarah, menyiapkan perlengkapan dan menyiapkan jaja. Sedangkan kegiatan pada tahap pelaksanaan antara lain kegiatan dirumah pengantin laki-laki, kegiatan dijalan menuju rumah pegantin perempuan dan kegiatan dirumah pengantin perempuan. Sementara kegiatan pada tahap penutup antara lain pembacaan do’a dan salaman. (2) Nilai-nilai yang terkandung pada tradisi bejango adalah nilai sosial budaya yang meliputi nilai kebersamaan, dan nilai silaturrahmi yang ditandai dengan kedatanagan keluarga pengantin laki-laki beserta rombongannya bejango kerumah keluarga pengantin perempuan. Sedangkan nilai budaya yang terkandung dalam tradisi bejango yaitu bagaimana kita diajarkan untuk selalu menjaga dan melestarikan setiap kebudayaan yang menjadi warisan nenek moyang kita, Karena dalam tradisi tersebut mengandung nilai-nilai yang sangat mendalam dan merupakan adat dan tradsisi yang harus tetap diperhankan kuhususunya bagi masyrakat di Desa Sengkerang.
PEMANFAATAN MEDIA PERMAINAN EDUKATIF KREATIF DALAM MELATIH KETERAMPILAN SOSIAL ANAK PAUD PERMATA BANGSA
Authors: Huda Khairul , Iman Nurul , Sa'di Kholisus 
Published: January 2023

Penelitian ini bertujuan bukan sekedar mengesahkan asumsi peneliti, namun, lebih pada tujuan dari penelitian, yaitu: Mengetahui Bagaiman Pemanfaatan Media Permainan Edukatif Kreatif Dalam Melatih Keterampilan Sosial Anak Paud Permata Bangsa. Sehingga mampu membuat pemikir/pendidik pendidikan anak usia dini bersikap aktif untuk mengarahkan agar peserta didik mampu mengaktualisasikan pemnbelajaran dalam dirinya dan lingkungan dimana ia berada. Model penelitian dilakukan berdasarkan penyusunan data menurut Miles dan Huberman, tahapan yang dilalui yaitu reduksi data, display data dan kesimpulan. Adapun teknik pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis data kualitatif yang digunakan untuk menjelaskan hasil penelitian. Penelitianini bukan sekedar bertujuan mengesahkan asumsi peneliti, namun, lebih pada tujuan dari penelitian, yaitu: Mengetahui Bagaiman Pemanfaatan Media Permainan Edukatif Kreatif Dalam Melatih Keterampilan Sosial Anak Paud Permata Bangsa? Tahapan yang sudah dilaksanakan selama penelitian berlangsung, dan hasil penelitian menunjukkan bahwa lembaga Paud Permata Bangsa belum maksimal dalam Mengetahui Bagaiman Pemanfaatan Media Permainan Edukatif Kreatif Dalam Melatih Keterampilan Sosial Anak Paud Permata Bangsa dikarenakan masih kurannya tenaga profesional, anak-anak masih harus beradaptasi dengan kegiatan permainan sosial, masih harus pelatihan dalam mengambangkan media permainan yang kratif yang mampu menstimulasi keterampilan sosial anak, menggali konpetensi keperibadian, konpetensi sosial dan konpetensi pedagogik serta melakukan sosialisasi atau pelatihan dalam rangka mengmbangkan ragam media permainan yang bisa menstimulasi perkembangan keterampilan sosial anak. Kata Kunci : Permainan Edukatif Kreatif, Keterampilan Sosial.
Effectiveness of Decision Support System for Hydroponic Plant Nutrient Selection Using Apriori Algorithm Method
Authors: Manurung Silvi Khairiyah , Lubis Riri Syafitri 
Published: January 2023

Hydroponics is an agricultural system that uses water as its growing medium by adding nutrients to plants without using soil. In hydroponic cultivation, the thing that needs to be considered is the provision of an optimal dose of nutrient solution as a food source for plants. The provision of nutrients that are not in accordance with the needs of plants results in plants stopping growing, so that plants do not take care of each other. The type of nutrition commonly used in hydroponic plants is AB mix. However, the use of AB mix as a hydroponic nutrient also has disadvantages, namely synthetics and the price of AB mix nutrients are quite expensive. Therefore, alternative nutrients are needed that have the potential to be used as hydroponic nutrients. By analyzing hydroponic plant assessment data so that the rules of linkage between combinations of goods are found and form a pattern of itemset combinations with apriori algorithm. The association technique aims to find matching links in the database. From the results of data mining calculations using apriori algorithms, nutrient assessment data on hydroponic plants with the minimum support 20% and the minimum confidence 70%, formed five rules on hydroponic plant nutrition. One of the best rules is that AB mix nutrition is used on cucumber, spinach, celery, and kailan plants, so with 100% probability that POC nutrients will be good to also use on cucumber, spinach, celery, and kailan plants.
Fractured morphology of femoral head associated with subsequent femoral neck fracture: Injury analyses of 2D and 3D models of femoral head fractures with computed tomography
Authors: Wu Shenghui , Wang Wei , Li Ruiyang , Guo Jingyi , Miao Yu , Li Guangyi , Mei Jiong 
Published: January 2023

Background: The injury of femoral head varies among femoral head fractures (FHFs). In addition, the injury degree of the femoral head is a significant predictor of femoral neck fracture (FNF) incidence in patients with FHFs. However, the exact measurement methods have yet been clearly defined based on injury models of FHFs. This study aimed to design a new measurement for the injury degree of the femoral head on 2D and 3D models with computed tomography (CT) images and investigate its association with FHFs with FNF.Methods: A consecutive series of 209 patients with FHFs was assessed regarding patient characteristics, CT images, and rate of FNF. New parameters for injury degree of femoral head, including percentage of maximum defect length (PMDL) in the 2D CT model and percentage of fracture area (PFA) in the 3D CT-reconstruction model, were respectively measured. Four 2D parameters included PMDLs in the coronal, cross-sectional and sagittal plane and average PMDL across all three planes. Reliability tests for all parameters were evaluated in 100 randomly selected patients. The PMDL with better reliability and areas under curves (AUCs) was finally defined as the 2D parameter. Factors associated with FNF were determined by binary logistic regression analysis. The sensitivity, specificity, likelihood ratios, and positive and negative predictive values for different cut-off values of the 2D and 3D parameters were employed to test the diagnostic accuracy for FNF prediction.Results: Intra- and inter-class coefficients for all parameters were ≥0.887. AUCs of all parameters ranged from 0.719 to 0.929 (p &lt; 0.05). The average PMDL across all three planes was defined as the 2D parameter. The results of logistic regression analysis showed that average PMDL across all three planes and PFA were the significant predictors of FNF (p &lt; 0.05). The cutoff values of the average PMDL across all three planes and PFA were 91.65% and 29.68%. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, predictive positive value and negative predictive value of 2D (3D) parameters were 91.7% (83.3%), 93.4% (58.4%), 13.8 (2.0), 0.09 (0.29), 45.83% (10.87%), and 99.46% (98.29%).Conclusion: The new measurement on 2D and 3D injury models with CT has been established to assess the fracture risk of femoral neck in patients with FHFs in the clinic practice. 2D and 3D parameters in FHFs were a feasible adjunctive diagnostic tool in identifying FNFs. In addition, this finding might also provide a theoretic basis for the investigation of the convenient digital-model in complex injury analysis.
Micro-fragmented and nanofat adipose tissue derivatives: In vitro qualitative and quantitative analysis
Authors: Cicione Claudia , Vadalà Gianluca , Di Giacomo Giuseppina , Tilotta Veronica , Ambrosio Luca , Russo Fabrizio , Zampogna Biagio , Cannata Francesca , Papalia Rocco , Denaro Vincenzo 
Published: January 2023

Introduction: Adipose tissue is widely exploited in regenerative medicine thanks to its trophic properties, mainly based on the presence of adipose-derived stromal cells. Numerous devices have been developed to promote its clinical use, leading to the introduction of one-step surgical procedures to obtain minimally manipulated adipose tissue derivatives. However, only a few studies compared their biological properties. This study aimed to characterize micro-fragmented (MAT) and nanofat adipose tissue (NAT) obtained with two different techniques.Methods: MAT, NAT and unprocessed lipoaspirate were collected from surgical specimens. RNA extraction and collagenase isolation of stromal vascular fraction (SVF) were performed. Tissue sections were analysed by histological and immunohistochemical (collagen type I, CD31, CD34 and PCNA) staining to assess tissue morphology and cell content. qPCR was performed to evaluate the expression of stemness-related (SOX2, NANOG and OCT3/4), extracellular matrix (COL1A1) and inflammatory genes (IL1β, IL6 and iNOS). Furthermore, multilineage differentiation was assessed following culture in adipogenic and osteogenic media and staining with Oil Red O and Alizarin red. ASC immunophenotype was assessed by flow cytometric analysis of CD90, CD105, CD73 and CD45.Results: Histological and immunohistochemical results showed an increased amount of stroma and a reduction of adipocytes in MAT and NAT, with the latter displaying the highest content of collagen type I, CD31, CD34 and PCNA. From LA to MAT and NAT, an increasing expression of NANOG, SOX2, OCT3/4, COL1A1 and IL6 was noted, while no significant differences in terms of IL1β and iNOS emerged. No statistically significant differences were noted between NAT and SVF in terms of stemness-related genes, while the latter demonstrated a significantly higher expression of stress-related markers. SVF cells derived from all three samples (LA, MAT, and NAT) showed a similar ASC immunoprofile as well as osteogenic and adipogenic differentiation.Discussion: Our results showed that both MAT and NAT techniques allowed the rapid isolation of ASC-rich grafts with a high anabolic and proliferative potential. However, NAT showed the highest levels of extracellular matrix content, replicating cells, and stemness gene expression. These results may provide precious clues for the use of adipose tissue derivatives in the clinical setting.
Study of the disaster-causing mechanism and reinforcement measures for soft rock deformation and lining cracking
Authors: Shi J. W. , Zhou P. Y. , Li X. , Fan S. Y. , Zhou Z. F. , Zhi B. , Cheng Y. 
Published: January 2023

Underground engineering construction is facing increasingly complex geological conditions and engineering challenges, such as surrounding rock deformation and lining cracking, that seriously threaten the safety of tunnel construction and operation. Aiming at these problems, a pipeline tunnel crossing jointed expansive mudstone strata was taken as an example, and the disaster characteristics of surrounding rock and lining were analyzed through field investigation. The disaster-causing mechanism and corresponding control measures were studied through laboratory tests and numerical simulations, which were then applied to actual construction. Meanwhile, the deformation and stress response of the surrounding rock and tunnel structure were analyzed and investigated through monitoring and numerical data. The results showed that the vault settlement and horizontal convergence deformation of surrounding rock were reduced by 64.69 mm and 54.74 mm, respectively, under the improved construction scheme. The maximum surrounding rock stress was 430.26 kPa under the improved construction scheme, which was 18.15% lower than the original stress. The maximum axial force of the steel arch frame was 33.02 kN, ensuring the stability of the supporting structure and tunnel construction safety. Finally, the rationality and effectiveness of the reinforcement measures adopted were assessed.
Clinical characteristics and genetic analysis of a Chinese pedigree of type 2 diabetes complicated with interstitial lung disease
Authors: Zhang Qinghua , Wang Yan , Tian Chang , Yu Jinyan , Li Yanlei , Yang Junling 
Published: January 2023

PurposeDiabetes mellitus is a systemic metabolic disorder which may target the lungs and lead to interstitial lung disease. The clinical characteristics and mechanisms of type 2 diabetes mellitus (T2DM) complicated with interstitial lung disease (ILD) have been studied. However, little work has been done to assess genetic contributions to the development of T2DM complicated with ILD.MethodA pedigree of T2DM complicated with ILD was investigated, and the whole genome re-sequencing was performed to identify the genetic variations in the pedigree. According to the literature, the most valuable genetic contributors to the pathogenesis of T2DM complicated with ILD were screened out, and the related cellular functional experiments were also performed.ResultsA large number of SNPs, InDels, SVs and CNVs were identified in eight subjects including two diabetic patients with ILD, two diabetic patients without ILD, and four healthy subjects from the pedigree. After data analysis according to the literature, MUC5B SNP rs2943512 (A &gt; C) was considered to be an important potentially pathogenic gene mutation associated with the pathogenesis of ILD in T2DM patients. In vitro experiments showed that the expression of MUC5B in BEAS-2B cells was significantly up-regulated by high glucose stimulation, accompanied by the activation of ERK1/2 and the increase of IL-1β and IL-6. When silencing MUC5B by RNA interference, the levels of p-ERK1/2 as well as IL-1β and IL-6 in BEAS-2B cells were all significantly decreased.ConclusionThe identification of these genetic variants in the pedigree enriches our understanding of the potential genetic contributions to T2DM complicated with ILD. MUC5B SNP rs2943512 (A &gt; C) or the up-regulated MUC5B in bronchial epithelial cells may be an important factor in promoting ILD inT2DM patients, laying a foundation for future exploration about the pathogenesis of T2DM complicated with ILD.
Dietary oleic acid contributes to the regulation of food intake through the synthesis of intestinal oleoylethanolamide
Authors: Igarashi Miki , Iwasa Kensuke , Hayakawa Tetsuhiko , Tsuduki Tsuyoshi , Kimura Ikuo , Maruyama Kei , Yoshikawa Keisuke 
Published: January 2023

IntroductionAmong the fatty acid ethanolamides (FAEs), oleoylethanolamide (OEA), linoleoylethanolamide (LEA), and palmitoylethanolamide (PEA) are reported to be involved in feeding regulation. In particular, OEA is well characterized as a satiety signal. Following food consumption, OEA is synthesized from oleic acid (OA) via an N-acyl phosphatidylethanolamine-specific phospholipase D-dependent pathway in the gastroenterocytes, and OEA induces satiety by recruiting sensory fibers. Thus, we hypothesized that dietary OA is an important satiety-inducing molecule. However, there has been no direct demonstration of the effect of dietary OA on satiety induction without the influence of the endogenous biosynthesis of OA from stearic acid (SA) or other FAEs.MethodsIn this study, we used two experimental diets to test our hypothesis: (i) an OA diet (OAD; 38.4 mg of OA/g and 7.2 mg of SA/g) and (ii) a low OA diet (LOAD; 3.1 mg of OA/g and 42.4 mg of SA/g).ResultsRelative to mice fed the OAD, mice fed the LOAD for two weeks exhibited reduced levels of jejunal OEA but not jejunal LEA and PEA. The LOAD-fed mice showed an increase in food intake and body weight gain. Moreover, LOAD-induced increase in food intake was immediately observed after the switch from the OAD, whereas these effects were diminished by the switch back to the OAD. Furthermore, treatment with OA and OEA diminished the effects of LOAD on food intake.ConclusionCollectively, these results show that dietary OA is a key factor in the reduction of food intake and increase in satiety mediated by OEA signaling.
Obesity management: Attitudes and practice of Italian endocrinologists
Authors: Chianelli Marco , Busetto Luca , Attanasio Roberto , Disoteo Olga Eugenia , Borretta Giorgio , Persichetti Agnese , Samperi Irene , Scoppola Alessandro , Paoletta Agostino , Grimaldi Franco , Papini Enrico , Nicolucci Antonio 
Published: January 2023

IntroductionObesity is a global pandemic and is cause of serious concern in all regions of the world. It is important to raise the attention of health care professionals in order to provide early treatment of patients with obesity. Obesity management, however, varies greatly amongst endocrinologists with respect to attitudes to diagnosis and treatment. Aim of this study was to identify practices and needs of Italian endocrinologists with respect to people with obesity.MethodsIn this study, all members of the Italian Association of Clinical Endocrinologists (AME) were invited to participate in a web-based survey concerning the management of obesity.ResultsThe response rate was 24.1% (542/2248). Nutritional and obesity problems were reported as major areas of interest by 29.4% of the participants. A large proportion of patients seeking an endocrine consultation for other reasons are affected by obesity, but one in five respondents addressed the issue in 25% or less of the cases, while one in three always dealt with the problem. Obesity was managed personally/within a dedicated team by 42.6% of participants, while the remainders referred the patient to a dietician/nutritionist or a 2nd level center for obesity therapy. Metformin was used in a median of 30% of the patients (Interquartile range: 10-50) and liraglutide in 10% of the cases (IQR 0-30), while orlistat (median 0%; IQR 0-10) and naltrexone/bupropion (median 0%; IQR 0-5) were seldom prescribed. Cost of therapy was considered as the major limitation to the use of anti-obesity drugs, affecting adherence to long-term treatment. According to 41.9% of respondents, psychological support should be offered to all patients with obesity. Finally, 56% of participants believe that the availability of new drugs will increase the number of patients candidate to drug therapy.DiscussionIn conclusion, it is of primary importance to raise the awareness of endocrinologists towards the problem of obesity and increase their confidence in managing this pathological condition.
Risk prediction for central lymph node metastasis in isolated isthmic papillary thyroid carcinoma by nomogram: A retrospective study from 2010 to 2021
Authors: Zhao Yu , Shi Wei , Dong Fang , Wang Xiuhua , Lu Chong , Liu Chunping 
Published: January 2023

BackgroundIsthmic papillary thyroid carcinoma (IPTC) is an aggressive thyroid cancer associated with a poor prognosis. Guidelines elaborating on the extent of surgery for IPTC are yet to be developed. This study aims to construct and validate a model to predict central lymph node metastasis (CLNM) in patients with IPTC, which could be used as a risk stratification tool to determine the best surgical approach for patients.MethodsElectronic medical records for patients diagnosed with isolated papillary thyroid carcinoma who underwent surgery at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, from January 2010 to December 2021 were reviewed. All patients who underwent thyroidectomy with central neck dissection (CND) for isolated IPTC were included. We conducted univariate and multivariate logistic regression analyses to assess risk factors for ipsilateral and contralateral CLNM and the number of CLNM in IPTC patients. Based on the analysis, the nomogram construction and internal validations were performed.ResultsA total of 147 patients with isolated IPTC were included. The occurrence of CLNM was 53.7% in the patients. We identified three predictors of ipsilateral CLNM, including age, gender, and size. For contralateral CLNM, three identified predictors were age, gender, and capsular invasion. Predictors for the number of CLNM included age, gender, capsular invasion, tumor size, and chronic lymphocytic thyroiditis (CLT). The concordance index(C-index) of the models predicting ipsilateral CLNM, contralateral CLNM, 1-4 CLNM, and ≥5 CLNM was 0.779 (95%CI, 0.704, to 0.854), 0.779 (95%CI, 0.703 to 0.855), 0.724 (95%CI, 0.629 to 0.818), and 0.932 (95%CI, 0.884 to 0.980), respectively. The corresponding indices for the internal validation were 0.756 (95%CI, 0.753 to 0.758), 0.753 (95%CI, 0.750 to 0.756), 0.706 (95%CI, 0.702 to 0.708), and 0.920 (95%CI, 0.918 to 0.922). Receiver operating characteristic (ROC) curves, calibration, and decision curve analysis (DCA) results confirmed that the three nomograms could precisely predict CLNM in patients with isolated IPTC.ConclusionWe constructed predictive nomograms for CLNM in IPTC patients. A risk stratification scheme and corresponding surgical treatment recommendations were provided accordingly. Our predictive models can be used as a risk stratification tool to help clinicians make individualized surgical plans for their patients.