bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adhesive bonding of glass-fibre thermoplastic composite: process optimisation and sustainability analysis using LCA methodology
Authors: Mandolfino Chiara , Cassettari Lucia , Lertora Enrico , Pizzorni Marco 
Published: June 2023

Abstract
In recent years, the transport industry has increasingly been confronted with the need for construction solutions that, at parity of performance, minimise the weight of products to save on fuel consumption, with benefits for operating costs and reduced pollutant emissions. In parallel, great attention has been paid to the challenge of integrating more sustainable circular approaches to manufacturing, which involve optimising the entire product cycle, from design to fabrication, assembly, and eventual reuse/recycling. In this context, the use of thermoplastic composite materials in combination with adhesive bonding is attracting increasing attention to achieve this dual objective. Therefore, the proposed research focuses on the experimental and statistical optimisation of an adhesive bonding process for glass-fibre reinforced composite substrates with polypropylene matrix. A low-pressure plasma pre-bonding surface treatment is adopted, and its effectiveness in enhancing joint performance compared to more conventional preparations for plastics is discussed. By varying plasma parameters according to the Design of Experiments statistical approach, the joint response is studied in terms of tensile shear strength and modelled in accordance with the Response Surface Methodology to identify the optimum condition of process parameters within the established system boundaries. Two alternative scenarios – namely, joints with thermoplastic composite or thermoset composite substrates – are then analysed by Life Cycle Assessment methodology and compared according to their relative environmental impact, demonstrating that glass-fibre thermoplastic composite joints are competitive alternatives to thermoset joints in terms of mechanical performance achieved, but significantly preferable with regard to environmental sustainability.
Utility of needle biopsy in centrally located lung cancer for genome analysis: a retrospective cohort study
Authors: Kunimasa Kei , Matsumoto Shingo , Honma Keiichiro , Tamiya Motohiro , Inoue Takako , Kawamura Takahisa , Tanada Satoshi , Miyazaki Akito , Kanzaki Ryu , Maniwa Tomohiro , Okami Jiro , Matsumoto Yuji , Goto Koichi , Nishino Kazumi 
Published: June 2023

Abstract
Background
It is essential to collect a sufficient amount of tumor tissue for successful next-generation sequencing (NGS) analysis. In this study, we investigated the clinical risk factors for avoiding re-biopsy for NGS analysis (re-genome biopsy) in cases where a sufficient amount of tumor tissue could not be collected by bronchoscopy.
Methods
We investigated the association between clinical factors and the risk of genome re-biopsy in patients who underwent transbronchial biopsy (TBB) or endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and required re-genome biopsy in cases enrolled in LC-SCRUM Asia, a prospective nationwide genome screening project in Japan. We also examined whether the frequency of re-biopsy decreased between the first and second halves of the enrolment period.
Results
Of the 572 eligible patients, 236 underwent TBB, and 134 underwent EBUS-TBNA. Twenty-four TBBs required re-genome biopsy, and multivariate analysis showed that the risk of re-biopsy was significantly increased in lesions where the tumor lesion was centrally located. In these cases, EBUS-TBNA should be utilized even if the lesion is a pulmonary lesion. However, it should be noted that even with EBUS-TBNA, lung field lesions are at a higher risk of re-canalization than mediastinal lymph node lesions. It was also found that even when tumor cells were detected in rapid on-site evaluation, a sufficient amount of tumor tissue was not always collected.
Conclusions
For centrally located pulmonary mass lesions, EBUS-TBNA, rather than TBB, can be used to obtain tumor tissues that can be analyzed by NGS.
Corruption and adolescent mental health: Evidence from Chinese junior high school admissions
Authors: Yuan Hongbin , Li Danyang , Yang Feiyan 
Published: June 2023

Abstract

Through preferential treatment by education officials or through bribery, some adolescents can obtain admission to a junior high school. However, It is unclear whether it affects the mental health of adolescents. This study used Propensity Score Matching (PSM) to examine the effects of corruption on adolescent mental health. A total of 17,254 junior high school students sample (11-18 years old; 48.7% girls and 53.1% boys) were used from the China Education Panel Survey (CEPS). 14.1% of adolescents attended a junior high school by corrupt means, corruption had a significantly negative effect on the mental health of these adolescents (ATT = -0.388, p < 0.01), the reasons grounded in the fact that they received more criticisms from teachers (ATT = 0.081, p < 0.01) and wanted to leave their current school (ATT = 0.099, p < 0.01). In general, corruption in the admissions process can have detrimental effects on the mental health of adolescents. This study extends the previous articles on how to improve adolescent mental health and complements the application of cognitive dissonance theory. Findings from this study revealed that anti-corruption in the education sector is necessary, and the institutional design to ensure fair enrolment in basic education will contribute to the mental health of adolescents.
Staphylococcal superantigen-like protein 10 enhances the amyloidogenic biofilm formation in Staphylococcus aureus
Authors: Rahman Shakilur , Das Amit Kumar 
Published: June 2023

Abstract
Staphylococcus aureus is a highly infectious pathogen that represents a significant burden on the current healthcare system. Bacterial attachment to medical implants and host tissue, and the establishment of a mature biofilm, play an important role in chronic diseases such as endocarditis, osteomyelitis and wound infections. These biofilms decrease bacterial susceptibility to antibiotics and immune defences, making the infections challenging to treatment. S. aureus produces numerous exotoxins that contribute to the pathogenesis of the bacteria. In this study, we have identified a novel function of staphylococcal superantigen-like protein 10 (SSL10) in enhancing the formation of staphylococcal biofilms. Biofilm biomass is significantly increased when SSL10 is added exogenously to bacterial cultures, whereas SSL2 and SSL12 are found to be less active. Exogenously added SSL10 mask the surface charge of the bacterial cells and lowers their zeta potential, leading to the aggregation of the cells. Moreover, the biofilm formation by SSL10 is governed by amyloid aggregation, as evident from spectroscopic and microscopic studies. These findings thereby give the first overview of the SSL-mediated amyloid-based biofilm formation and further drive the future research in identifying potential molecules for developing new antibacterial therapies against Staphylococcus aureus.
Investigating Ovality and Wall-Thinning Behaviors in Free-Form Bending of Thin Pipe Bends with Varying Guider Length and Roller Die Diameter
Authors: Periasamy Govindaraj , CS Arun 
Published: June 2023

Abstract
This study investigates the influence of guider length and roller die diameter on the ovality and thickness reduction of pipe bends formed using the freeform bending method. Finite element simulation is employed to analyze a three-segment pipe bend. The analysis reveals that the beginning of the third bending segment exhibits the highest ovality, which directly correlates with circumferential strain. Optimal values for roller die diameter and guider length are determined for the given geometry, and a spatial bend design is proposed to minimize the percentage of ovality. The findings provide valuable insights for optimizing the bending process and achieving reduced ovality in pipe bends.
The Classification of the Prostate Cancer based on Transfer Learning Techniques
Authors: Khedr Ola S. , Wahed Mohamed E. , Al-Attar Al-Sayed R. , Abdel-Rehim E. A. 
Published: June 2023

Abstract

The most common cause of mortality worldwide and the most common male cancer is prostate cancer. According to the American Cancer Society. In the United States, there were 164,690 new instances of prostate cancer and at least 29,430 deaths from the disease in 2018, making up 9.5% of all new cancer cases. This will have a significant socioeconomic impact. Having the ability to determine the aggressiveness risk of confirmed prostate cancer could enhance the choice of proper treatment for individuals. This could lead to better outcomes, especially in terms of prostate cancer specific mortality. Deep learning-based significant prostate cancer classification has attracted a lot of attention because it may one day be used to support therapeutic decision-making. In this research we propose four models for classification the prostate cancer based on transfer learning algorithms (EfficentNet, DenseNet and Xception). We used two datasets for diagnosing prostate cancer. One of them is the standard dataset which consists of six grades of cancers and the other is a personal dataset from laboratory which is new dataset from treated patients at the hospital of Zagazig university. The results are obtained by using the standard dataset is approximately 93.6% accuracy using EfficientNetB7 pretrained model. The results of the created dataset are 97.08%, 97.98%, 98.87% by using EfiicientNet, DenseNet121 and Xception transfer learning models respectively. The results were compared with the state of arts, and it outperform all of them and also the model can be used in applications.
The dynamic Epstein-Barr virus-related serological monitor on a large-scale population-based screening cohort: a ten-year prospective follow-up study
Authors: Xiong Lei , Lian Shifeng , Du Yun , Yu Xia , Wu Biaohua , Li Fugui , Zhan Jiyun , Liang Xuejun , Ji Mingfang 
Published: June 2023

Abstract
Background:
Previous large-scale screening studies have shown that Epstein-Barr virus antibodies (EBV) can facilitate early detection of nasopharyngeal carcinoma (NPC). However, the screening interval in population-based NPC screening remains unclear.
Methods:
We analyzed two previously selected EBV antibodies in plasma specimens to screen participants who participated in the NPC screening assessment in Xiaolan Town, Zhongshan City from August 2009 to September 2010. At the initial screening results, participants were divided into three groups according to the prediction formula calculated by their antibody levels (serological high-, medium- and low-groups). Participants at medium- and high-risk in initial screening were scheduled to be followed up with serological testing annually in the following 3 years, afterwards, participants can decide to continue screening or not. Participants were followed up annually through the Cancer Registry of Zhongshan City. NPC cases were confirmed by histology.
Results:
Among 16712 total subjects, 56 NPC cases were identified. In high-risk group, 83.8% of NPC were detected at initial screening and in first year of follow-up. All patients in high-risk group with persistent high-risk before diagnosis. 90% of subjects with NPC in medium-risk group rise to the Serological high risk before diagnosis. Among 16658 non-NPC subjects, the percentage of high, medium, and low risk subjects in each group fluctuated around (54.8%, 26.4%, 18.8%), (28.2%, 38.4%, 33.4%), and (8.6%, 17.9%, 73.5%), respectively, during the 10-year follow-up.
Conclusion:
NPC cases are mainly diagnosed at the first screening serologic in high risk, the persistent high-risk and medium to high serologic risk objective. Six years of follow-up is appropriate for individuals with persistent high serologic risk and for individuals with medium to high serologic risk.
FOXD1 promotes proliferation, migration and epithelial-mesenchymal transformation of esophageal squamous cell carcinoma by targeting SNAI1
Authors: Wu Zheng , Liu Minghui , Zhu Hui , Guo Shenghu , Zhang Yuehua , Wang Zhiyu 
Published: June 2023

Abstract
The transcription factor forkhead box D1 (FOXD1) is an important member of the FOX family, which is widely expressed in human embryonic cells and is thought to regulate organogenesis. It has been shown that FOXD1 could affect proliferation, migration, and angiogenesis of various tumors and its deletion and overexpression in organisms will undoubtedly have important influence on the change of cell fate and the occurrence of tumors. However, the underlying functions and molecular mechanisms of FOXD1 in esophageal squamous cell carcinoma (ESCC) have not been fully clarified. According to the present study, the expression levels and functional roles of FOXD1 were investigated, and its prognostic value and molecular mechanisms in tumorigenesis and progression of ESCC were clarified. The expression level of FOXD1 was significantly upregulated in ESCC tissues and cell lines, and correlated with TNM stage, pathological differentiation, depth of invasion, and LN metastasis. Moreover, FOXD1 promoted cells migration and invasion as well as participated in TGF-β1 induced epithelial-mesenchymal transition (EMT) process. Furthermore, a positive correlation between FOXD1 and SNAI1 was explored in ESCC. FOXD1 could directly bind to promoter regions of SNAI1 gene, leading to transcriptional promotion of SNAI1 in human esophageal cancer cells. Taken together, FOXD1 may play a tumor activator role in ESCC and may be applied as a new therapeutic target and prognostic marker for ESCC.
Enhanced terahertz phonon polariton in lithium niobate wafer
Authors: Li Yutong , Zhang Baolong , Li Yifei , Wu Xiaojun , Xu Xitan , Lu Yao , Wu Qiang , Wang Xuan , Lei Hongyi , Ma Jinglong , Liao Guoqian 
Published: June 2023

Abstract
Terahertz (THz) phonon polariton, a fundamental quasi-particle that couples phonon and electromagnetic fields in THz frequencies, is present in diverse materials, imparting multifarious functionalities to comprehend THz electromagnetic wave-matter interactions while enabling diverse THz optoelectronic devices and integrated systems. Despite the potential of THz phonon polariton, its proliferation is hampered by the absence of strong-field THz sources and highly sensitive electromagnetic spectra detection tools in the THz region. In this study, we showcase the efficient generation and amplification of THz phonon polaritons in lithium niobate wafers via optical-to-THz phase matching employing tilted pulsefront technique. The THz phonon polariton is imaged using spatiotemporal phase contrast imaging, with lateral pumping and phase matching allowing for the extension of the effective interaction length in lithium niobate wafers exceeding several millimeters. The observed THz phonon polariton in lithium niobate using tilted pulsefront phase matching unlocks new nonlinear THz optics possibilities. We envision that it may lead to potential applications in on-chip THz photonic devices and systems based on lithium niobate materials and its integrated heterostructures.
Seismically-induced landslide hazard mapping of Aba region, Sichuan Province for future seismic scenarios using LR modelling and probabilistic seismic hazard analysis
Authors: Shao Xiaoyi , Ma Siyuan , Xu Chong , Cheng Jia , Xu Xiwei 
Published: June 2023

Abstract
The purpose of this work is to carry out seismic-induced landslide hazard mapping for future seismic scenarios of Aba region. 9 earthquake events that occurred in Aba prefecture of Sichuan province and neighboring areas are selected, which include a total of 251260 landslide records. We used 13 influencing factors including elevation, slope, aspect, relief, topographic wetness index (TWI), topographic position index (TPI), ground motion, distance to active faults, vegetation coverage, distance to roads, lithology, and annual rainfall to establish the LR modelling. Based on the probabilistic seismic hazard analysis (PSHA), the distribution of predicted seismic motion under four earthquake scenarios are calculated including frequent earthquake, basis earthquake, rare earthquake and very rare earthquake. Using the PGA distribution of the four scenarios as input data, we calculated the occurrence probability of coseismic landslides in the entire Aba area under the action of different ground motions. The result shows that the high-hazard areas are mainly concentrated in the Longmenshan fault zone, and the southern area of Kangding is also a potential high-hazard area for landsliding. Meanwhile, as the probability of exceedance decreases, the probability of corresponding earthquake landslides and the area of high-hazard region also significantly increase. Especially, the Pengguan complex rock mass in the southwest of the Longmenshan fault zone is the potential high-hazard area for coseismic landslides.
Association between Body Mass Index and Outcomes after Autologous Breast Reconstruction: A Nationwide Inpatient Database Study in Japan
Authors: Karakawa Ryo , Konishi Takaaki , Yoshimatsu Hidehiko , Hashimoto Yohei , Matsui Hiroki , Fushimi Kiyohide , Yano Tomoyuki , Yasunaga Hideo 
Published: June 2023

Abstract
Background
Although autologous reconstruction following breast cancer surgery is common, little is known about the association between preoperative body mass index (BMI) and short-term surgical outcomes. This study investigated the association between BMI and short-term surgical outcomes in autologous breast reconstruction using a nationwide Japanese inpatient database.
Methods
We retrospectively identified female patients with breast cancer who underwent breast reconstruction using a pedicled flap or free flap from July 2010 to March 2020. Multivariable regression analyses and restricted cubic spline analyses were conducted to investigate the associations between BMI and short-term outcomes with adjustment for demographic and clinical backgrounds.
Results
Of the 13,734 eligible patients, 7.1% and 22.2% had a BMI of < 18.5 kg/m2 and > 25 kg/m2, respectively. Compared with BMI of 18.5–21.9 kg/m2, overweight (25.0–29.9 kg/m2) and obese (≥ 30.0 kg/m2) were significantly associated with higher occurrences of takebacks (odds ratio, 1.74 [95% confidence interval, 1.28–2.38] and 2.89 [1.88–4.43], respectively) and overall complications (1.37 [1.20–1.57] and 1.77 [1.42–2.20], respectively). In the restricted cubic spline analyses, BMI showed J-shaped associations with takebacks, overall complications, local complications, and wound dehiscence. BMI also demonstrated linear associations with postoperative surgical site infection, duration of anesthesia, duration of drainage, length of stay, and hospitalization costs.
Conclusion
In autologous breast reconstruction following breast cancer surgery, a higher BMI was associated with takebacks, morbidity, a longer hospital stay, and higher total costs, whereas a lower BMI was associated with fewer surgical site infections, a shorter hospital stay, and lower total costs.
Development and validation the uterine fibroid symptom and quality of life short-form: based on classical test theory and modern test theory
Authors: Xu Wei , Zhang Jiayuan , Zhang Ruoyi , Chen Jiaojiao , Xu Fan , Shi Qiuling 
Published: June 2023

Abstract
Objectives
Previous research has shown that the self-consciousness and sexual function domain of the uterine fibroid symptom and quality of life (UFS-QoL) questionnaire exhibited poor adaptability and clinical applicability. In light of this, our objective was to develop a shorter version of the UFS-QoL questionnaire, while ensuring its reliability, validity, and clinical applicability, in order to enhance routine clinical assessments.
Methods
A secondary analysis was conducted on a prospective cohort study involving 20 Chinese hospitals and 2,411 Chinese women with fibroids. We employed both classical test theory (CTT) and item response theory (IRT) to select two items for each UFS-QoL subscale. In cases where inconsistencies arose from these two methods, we utilized responsiveness to identify items with a higher ability to detect change in clinical therapy. The short-form scale was evaluated for dimensionality, internal consistency reliability, and criterion and known-group validity through factor analysis, Cronbach's alpha, Spearman correlations, and independent samples t-tests. To assess the ability to detect change, we compared pre-treatment and post-treatment (6 and 12 months) scores using effect size and standardized response mean.
Results
Considering the poor adaptability and clinical applicability, we made the decision to remove the self-consciousness subscale and retain only one item from the sexual functioning subscale. As a result, we administered and validated the 11-item short-form version of UFS-QoL (UFS-QoL-11). UFS-QoL-11 exhibited a strong correlation with UFS-QoL in each subscale, with correlation coefficients exceeding 0.7 (all P < 0.001). Exploratory factor analysis identified three subscales (symptom severity, concern, and daily life interference) with eigenvalues > 1 for UFS-QoL-11. The test items accounted for 64.46% of the total variance, slightly higher than the parent scale score of 63.60%. UFS-QoL-11 demonstrated excellent internal consistency and reliability across all subscales (> 0.7), representing a slight improvement compared to the full UFS-QoL. Furthermore, UFS-QoL-11 exhibited sensitivity in detecting varying levels of current health status, particularly at 6 and 12 months post-surgery. The responsiveness of UFS-QoL-11 was comparable to that of UFS-QoL, with all effect sizes > 0.5, demonstrating a strong ability to detect changes.
Conclusion
UFS-QoL-11 performs as well as the original version, while reducing the administrative burden by 70%. We firmly believe that the implementation of the newly developed UFS-QoL-11 has the potential to facilitate widespread, accurate, timely, and sensitive monitoring in both clinical and research settings.
Real time expression and in silico characterization of pea genes involved in salt and water-deficit stress
Authors: Farooq Muhammad , Ahmad Rafiq , Shahzad Muhammad , Rehman Saad Ur , Sajjad Yasar , Hassan Amjad , Shah Mohammad Maroof , Afroz Amber , Khan Sabaz Ali 
Published: June 2023

Abstract
Background
To tolerate salt and water-deficit stress, the plant adapts to the adverse environment by regulating its metabolism and expressing certain stress-induced metabolic pathways. This research analyzed the relative expression of four pea genes (proC, PAL1, SOD, and POX) in three pea varieties (Climax, Green grass, and Meteor) under different levels of salt and water-deficit stress.
Methods and Results
Results from RT-qPCR analysis showed increased expression of proC, PAL1, and POX genes, while SOD gene expression decreased under both stresses. Climax exhibited superior stress tolerance with elevated expression of proC and PAL1, while Meteor showed better tolerance through increased POX expression. Phylogenetic analysis revealed common ancestry with other species like chickpea, red clover, mung bean, and barrel clover, suggesting about the cross relationship among these plant species. Conserved domain analysis of respective proteins revealed that these proteins contain PLNO 2688, PLN02457, Cu-Zn Superoxide dismutase, and secretory peroxidase conserved domains. Furthermore, protein family classification indicated that the oxidation-reduction process is the most common chemical process involved in these stresses given to peas which validate the relationship of these proteins.
Conclusions
Salt and water-deficit stresses trigger distinct metabolic pathways, leading to the upregulation of specific genes and the synthesis of corresponding proteins. These findings further emphasize the conservation of stress-tolerance-related genes and proteins across various plant species. This knowledge enhances our understanding of plant adaptation to stress and offers opportunities for developing strategies to improve stress resilience in crops, thereby addressing global food security challenges.