bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Cardiovascular Events Among Patients With Head and Neck Cancer
Authors: Sun Lova , Brody Robert , Candelieri Danielle , Lynch Julie A. , Cohen Roger B. , Li Yimei , Getz Kelly D. , Ky Bonnie 
Published: June 2023

ImportanceCardiovascular (CV) disease is a substantial cause of morbidity and mortality in cancer due to shared risk factors and exposure to potentially cardiotoxic cancer therapy. However, our understanding of CV risk in patients with head and neck squamous cell carcinoma (HNSCC) is limited.ObjectiveTo define CV risk profiles, incident stroke, myocardial infarction (MI), and mortality in patients with HNSCC.Design, Setting, and ParticipantsThis retrospective, population-based cohort study included 35 897 US veterans with newly diagnosed HNSCC from January 1, 2000, to December 31, 2020. Data were analyzed from May 2022 to January 2023.ExposuresDemographic, cancer-specific, and treatment characteristics.Main OutcomesPrevalence of CV risk factors, medication use, and control at HNSCC diagnosis; cumulative incidence of stroke and MI; and all-cause death.ResultsOf 35 857 US veterans with HNSCC (median [IQR] age, 63 [58-69] years; 176 [0.5%] American Indian or Alaska Native, 57 [0.2%] Asian, 5321 [16.6%] Black, 207 [0.6%] Native Hawaiian or Other Pacific Islander, and 26 277 [82.0%] White individuals), there were high rates of former or current smoking (16 341 [83%]), hypertension (24 023 [67%]), diabetes (7988 [22%]), and hyperlipidemia (18 421 [51%]). Although most patients were taking risk-lowering medications, 15 941 (47%) had at least 1 uncontrolled CV risk factor. Black race was associated with increased risk of having uncontrolled CV risk factor(s) (relative risk, 1.06; 95% CI, 1.03-1.09), and patients with larynx cancer had higher rates of prevalent and uncontrolled risk factors compared with other cancer subsites. Considering death as a competing risk, the 10-year cumulative incidence of stroke and MI was 12.5% and 8.3%, respectively. In cause-specific hazards models, hypertension, diabetes, carotid artery stenosis, coronary artery disease, and presence of uncontrolled CV risk factor(s) were significantly associated with stroke and MI. In extended Cox models, incident stroke and MI were associated with a 47% (95% CI, 41%-54%) and 71% (95% CI, 63%-81%) increased risk of all-cause death, respectively.ConclusionThe results of this cohort study suggest that in HNSCC, the burden of suboptimally controlled CV risk factors and incident risk of stroke and MI are substantial. Modifiable CV risk factors are associated with risk of adverse CV events, and these events are associated with a higher risk of death. These findings identify populations at risk and potentially underscore the importance of modifiable CV risk factor control and motivate strategies to reduce CV risk in HNSCC survivorship care.
Effective use of an extraoral vacuum in preventing the dispersal of particulate matter from metal dental materials
Authors: Suito Hideki , Fujimoto Keiko , Goto Takaharu , Nagao Kan , Hosoki Hidehiko , Ichikawa Tetsuo 
Published: June 2023

Abstract

Objectives
When dentists adjust prostheses at the dental chairside, particulate matter (PM) from the dental material is dispersed. Little is known about the effective use of an extraoral vacuum (EOV) in preventing PM dispersal. This study aimed to evaluate the effective use of an EOV in preventing the dispersal of metal PM in dental offices.

Methods
The following experimental conditions were planned: the distance from the EOV to the metallic materials (50, 100, 150, and 200 mm), the horizontal angle between the long axis of the micromotor handpiece and EOV (0°, 45°, and 90°), and the operating time of the EOV (during grinding, during grinding and 1 min thereafter, during grinding and the preceding 1 min, 1 min before and after grinding, and during grinding). Carborundum and silicone points were used for grinding and PM dispersal. Diameters (0.3, 0.5, 1.0, and 3.0 μm) were measured using a laser particle counter.

Results
Depending on the instrument used to grind, there were undetectable PMs of different diameters (Carborundum point: 0.3 and 0.5 μm, Silicone point: 0.3 μm). PMNs were reduced as the distance from the EOV to metal materials decreased. Operating the EOV before grinding along the long axis of the micromotor handpiece was effective in reducing the PMNs.

Conclusion
PMNs dispersed when grinding metals were effectively reduced by positioning the EOV closer to the grinding surface (within 150 mm) along the long axis of the micromotor handpiece and operating the EOV before grinding.
Incorporation of Heteroatomic Fe Activates Rapid Catalytic Behaviors of Co3O4 Hollow Nanoplates Toward Advanced Lithium–Sulfur Batteries
Authors: Liu Jiabing , Li Gaoran , Luo Dan , Li Jianhui , Zhang Xinyu , Li Qiang , Li Haipeng , Zhang Yongguang , Chen Zhongwei 
Published: June 2023

AbstractLithium–sulfur (Li–S) battery is a highly attractive energy storage system due to its high capacity and great affordability. However, the parasitic shuttle effect and sluggish redox kinetics are perplexing the fulfillment of efficient battery electrochemistry. To tackle these challenges, herein, a hierarchical and hollow nanoplate assembled by Fe‐doped Co3O4 nanosheets (Fe–Co3O4 HHNPs) is meticulously designed as an advanced sulfur nanoreactor. The interlaced nanosheets establish a robust and porous network for fast charge transfer and efficient active site exposure. More importantly, the heteroatomic Fe incorporation tailors the electronic structure via local structure distortion and electron redistribution, contributing to massive active sites that lower the energy barrier for sulfur conversions. The resulting sulfur adsorption and catalyzation endow the Li–S cells with minimum capacity decay of 0.08% per cycle over 500 cycles and decent rate performance up to 5 C. Moreover, a high areal capacity of 9.0 mAh cm−2 after 55 cycles is also achievable under raised sulfur loading of 11 mg cm−2 and limited electrolyte (E/S = 3.9 µL mg−1). This work provides an elaborate and instructive paradigm for designing catalytic nanoreactors toward superior Li–S electrochemistry.
Highly Tuneable Photochromic Sodalites for Dosimetry, Security Marking and Imaging
Authors: Byron Hannah Charlotte , Swain Claudia , Paturi Pyry , Colinet Pauline , Rullan Raphaël , Halava Vesa , Le Bahers Tangui , Lastusaari Mika 
Published: June 2023

AbstractPhotochromic sodalites are considered for a plethora of possible applications, such as UV indexing and X‐ray imaging, but for many of these the materials are yet to be optimized. UV indexing can be improved through incremental adjustment of the activation energy of coloration from 300 to 410 nm through replacement of sulfur with selenium. By combining this and other methods of tuning presented in the literature, the excitation threshold and photochromism color can be tuned independently of one another. The range of possible absorption maxima is expanded to 420–680 nm, or almost the entire visible spectrum. Mixing low‐cost and easy‐to‐synthesize sodalites further broadens the possible range of colors and facilitates development of a unique sodalite mix capable of quantifying the doses of two types of UV radiation simultaneously. Finally, the response to X‐rays of these highly tuned sodalites is investigated, and it is found that they can be sensitized to produce clear, high‐contrast X‐ray images at significantly lower doses of radiation than those required by classic photochromic sodalite, Na8(AlSiO4)6(Cl,S)2.
Smartly Engineered Casein Manganese Oxide Nanobiomaterials and Its Potential Therapeutic Angiogenesis Applications for Wound Healing and Limb Ischemia
Authors: Haque Shagufta , Kotcherlakota Rajesh , Bhamidipati Pranav , Muralidharan Kathirvel , Sreedhar Bojja , Amanchy Ramars , Patra Chitta Ranjan 
Published: June 2023

AbstractRecent research offers several approaches for the advancement of manganese‐based nanomaterials for its therapeutic use. The present research paper reports the development of smartly engineered casein manganese oxide nanobiomaterials (CMnNP) using manganese chloride and casein under alkaline condition at room temperature. The CMnNP are systematically characterized by various analytical techniques. The biocompatibility of these nanomaterials is observed by in vitro cell viability and in vivo hemolysis assay. The nanomaterials (CMnNP) exhibit the pro‐angiogenic properties, established through various in vitro assays in endothelial cells and in vivo experiments. The interaction of manganese with different enzymes and angiogenic proteins is identified through in silico analysis that is further validated through in vitro western blot studies. This study also demonstrates the application of therapeutic angiogenesis of CMnNP for wound healing as well as hindlimb ischemia in C57BL/6J and BALB/c mouse model, respectively. The formation of redox signaling molecules (especially H2O2, O2˙−, and NO) in endothelial cells may be one of the plausible mechanisms for CMnNP‐mediated angiogenesis. Considering the results, the current study offers a nanomedical perspective for the therapy of various ischemic diseases as well as wound healing where angiogenesis involves is a crucial step.
Effect of Sodium Dodecyl Sulfate on Stability of MXene Aqueous Dispersion
Authors: Fan Baomin , Zhao Xiaoqi , Zhang Peng , Wei Yi , Qiao Ning , Yang Biao , Soomro Razium A. , Zhang Ran , Xu Bin 
Published: June 2023

AbstractMXenes suffer from severe oxidation and progressive degradation in aqueous media due to its poor chemical stability. Herein, sodium dodecyl sulfate (SDS) is employed as an efficient protectant for long‐term storage of Ti3C2Tx‐MXene aqueous dispersion. Experimental data support SDS's capability to protect oxidation‐prone sites on Ti3C2Tx nanosheets, providing extended colloidal stability of up to 213 days. Concentration‐dependent anti‐oxidation effect articulates that 1.5 mg mL−1 is deemed as an ideal SDS dose for Ti3C2Tx to achieve optimal oxidation‐resistance in aqueous solution. Additionally, a chroma strategy is developed to instantly and precisely measure the oxidation degree of Ti3C2Tx. Adsorption‐driven anti‐oxidation efficacy of SDS is further confirmed by optimized conformations with interaction energies of SDS on termination‐free and surface‐defective Ti3C2Tx through multiscale simulations. This proposed route is a step forward in broadening the horizons of experimental and theoretical investigations of MXenes with promising implications for long‐term storage and reliable applications.
Unique drought resistance strategies occur among monkeyflower populations spanning an aridity gradient
Authors: FitzPatrick Joshua A. , Doucet Braden I. , Holt Stacy D. , Patterson Courtney M. , Kooyers Nicholas J. 
Published: June 2023

AbstractPremiseAnnual plants often exhibit drought‐escape and avoidance strategies to cope with limited water availability. Determining the extent of variation and factors underlying the evolution of divergent strategies is necessary for determining population responses to more frequent and severe droughts.MethodsWe leveraged five Mimulus guttatus populations collected across an aridity gradient within manipulative drought and quantitative genetics experiments to examine constitutive and terminal‐drought induced responses in drought resistance traits.ResultsPopulations varied considerably in drought‐escape‐ and drought‐avoidance‐associated traits. The most mesic population demonstrated a unique resource conservative strategy. Xeric populations exhibited extreme plasticity when exposed to terminal drought that included flowering earlier at shorter heights, increasing water‐use efficiency, and shifting C:N ratios. However, plasticity responses also differed between populations, with two populations slowing growth rates and flowering at earlier nodes and another population increasing growth rate. While nearly all traits were heritable, phenotypic correlations differed substantially between treatments and often, populations.ConclusionsOur results suggest drought resistance strategies of populations may be finely adapted to local patterns of water availability. Substantial plastic responses suggest that xeric populations can already acclimate to drought through plasticity, but populations not frequently exposed to drought may be more vulnerable.
Cross Relaxation Channel Tailored Temperature Response in Er3+‐rich Upconversion Nanophosphor
Authors: Wu Kefan , Wang Enhui , Yuan Jun , Zuo Jing , Zhou Ding , Zhao Haifeng , Luo Yongshi , Zhang Ligong , Li Bin , Zhang Jiahua , Tu Langping , Zhang Hong 
Published: June 2023

AbstractRecently high doping of lanthanide ions (till 100 %) is realized unprecedentedly in nanostructured upconversion (UC) phosphors. However, oddly enough, this significant breakthrough did not result in a corresponding UC enhancement at ambient temperature, which hinders the otherwise very interesting applications of these materials in various fields. In this work, taking the Er3+‐rich UC nanosystem as an example, we confirm unambiguously that the phonon‐assisted cross relaxation (CR) is the culprit. More importantly, combining the theoretical modeling and experiments, the precise roles of different CR channels on UC energy loss are quantitatively revealed. As a result, lowering the temperature can exponentially enhance the relevant UC luminescence by more than two orders of magnitude. Our comprehension will play an important role in promoting the UC performance and further application of high doping rare earth materials. As a proof of concept, an Er3+‐rich core/multi‐shell nanophosphor is exploited which demonstrates the great potential of our finding in the field of ultra‐sensitive temperature sensing.
Tandem Guest‐Host‐Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus
Authors: Zhan Wenjun , Xu Lingling , Liu Zhiyu , Liu Xiaoyang , Gao Ge , Xia Tiantian , Cheng Xiaotong , Sun Xianbao , Wu Fu‐Gen , Yu Qian , Liang Gaolin 
Published: June 2023

AbstractStaphylococcus aureus (S. aureus) is able to hide within host cells to escape immune clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design of an adamantane (Ada)‐containing antibiotic‐peptide precursor Ada‐Gly‐Tyr‐Val‐Ala‐Asp‐Cys(StBu)‐Lys(Ciprofloxacin)‐CBT (Cip‐CBT‐Ada), we propose a strategy of tandem guest‐host‐receptor recognitions to precisely guide ciprofloxacin to eliminate intracellular S. aureus. Via guest‐host recognition, Cip‐CBT‐Ada is decorated with a β‐cyclodextrin‐heptamannoside (CD‐M) derivative to yield Cip‐CBT‐Ada/CD‐M, which is able to target mannose receptor‐overexpressing macrophages via multivalent ligand‐receptor recognition. After uptake, Cip‐CBT‐Ada/CD‐M undergoes caspase‐1 (an overexpressed enzyme during S. aureus infection)‐initiated CBT‐Cys click reaction to self‐assemble into ciprofloxacin nanoparticle Nano‐Cip. In vitro and in vivo experiments demonstrate that, compared with ciprofloxacin or Cip‐CBT‐Ada, Cip‐CBT‐Ada/CD‐M shows superior intracellular bacteria elimination and inflammation alleviation efficiency in S. aureus‐infected RAW264.7 cells and mouse infection models, respectively. This work provides a supramolecular platform of tandem guest‐host‐receptor recognitions to precisely guide antibiotics to eliminate intracellular S. aureus infection efficiently.
Exploring changes in family functioning when a child participates in a School‐Based Filial Therapy program
Authors: Cooper Jane , Yu Mong‐lin , MacKay Linda , Brown Ted 
Published: June 2023

AbstractChild focus is a central construct within Bowen family systems theory (Bowen theory). A clinical implication is that mental health treatment focusing on a child may unwittingly reinforce the operation of child‐focused processes, which undermine rather than enhance child well‐being. The concept of child focus in Bowen theory presents significant implications for professionals working in school settings and in fields such as children's mental health, which are inherently child‐focused. Bowen theory is the guiding theoretical framework for School‐Based Filial Therapy (SBFT). SBFT is a play therapy intervention that was initially established in remote and outer‐regional New South Wales, Australia in response to the low availability of children's mental health services and the significant barriers associated with caregiver engagement in children's mental health treatment. It involves trained school personnel facilitating therapeutic play sessions with children experiencing emotional–behavioural problems. The intervention occurs on school grounds, during school hours, and children's family members do not participate in the intervention. This mixed‐methods study examines the impact of children's participation in SBFT upon family functioning. Interviews with caregivers (n = 10) of children who participated in 10 SBFT sessions were analysed using content analysis. Quantitative data were collected using the Differentiation of Self Inventory – Short Form and Visual Analogue Scale – Family Functioning. A Wilcoxon signed rank test was used to analyse the pre‐ and post‐data. Qualitative outcomes indicated changes in the categories of child functioning, caregiver functioning, and extended family functioning, whilst child‐focused processes remained dominant but changed in intensity and valence following SBFT.
Synthesis, electrochemistry, and in vitro antileishmanial efficacy of novel ferrocenylazines
Authors: Möller Jennica , Kannigadu Christina , Aucamp Janine , Joseph Moegamat C. , Swarts Andrew J. , N'Da David D. 
Published: June 2023

Leishmaniasis is a zoonotic disease prevalent in 83–92 countries. This disease's current treatments are unsatisfactory because of a variety of shortcomings, including serious toxicity, variable efficacy, painful administration, and the occurrence of parasite resistance to these antileishmanial agents. The abovementioned limitations have urged the development of novel, reliable, and affordable agents to treat leishmaniasis. Ferrocenylazine derivatives were therefore synthesized for activity screening against Leishmania major and Leishmania donovani cell cultures. This emphasizes the urgent need for new effective antileishmanial agents. In search for such therapeutics, we synthesized and evaluated in vitro the antileishmanial activity of a series of azine derivatives based on the organometallic compound ferrocene. Two ferrocenylaldazines, 2l and 2q, were uncovered as mammalian cell nontoxic antileishmanial early leads, expressing submicromolar activity with IC50 values of 0.78 ± 0.03 and 0.46 ± 0.03 μM, respectively, against amastigote of L. donovani. Ferrocenylazines may therefore act as potential new antileishmanial agents, and the next objective will be the identification of the involved biological targets.
Excellent hydrophobic, superior ozone and UV resistant, and high thermal stable films from bio‐based natural rubber latex via fluorinating under mild conditions
Authors: Cheng Shihong , Liu Huan , Li Songyang , Cai Jiajun , Liao Shuangquan , Zhao Fuchun 
Published: June 2023

AbstractAs a renewable and widely applied bio‐based material, the relatively weak resistance of natural rubber (NR) resulting from the inherent unsaturated structure to the harsh environments limits their further applications in some special areas. Thus, the fluorinated natural rubber (FNR) latex was prepared with fluorinated acrylate as the monomer in aqueous emulsion system at ambient temperature. The fluorinating reaction, the structure and morphology of NR latex were examined. It was demonstrated that as the intrinsic surface layer of NR latex particles, the non‐rubber component hindered the penetrating of fluorinated monomer or initiator radicals into the inner NR Latex particles and reduce the grafting reactivity. The fluorination renders the resultant FNR latex film strong hydrophobicity and superior environmental resistance to UV, ozone, and heat. The defective time of the FNR latex film improved 65 times as long as the net NR latex film via ozone aging. The thermal decomposition temperature increased by 37.0°C compared with net NR latex film. This work provides a facile way for preparation of FNR with excellent stability under extreme environments such as high ozone concentration, high UV intensity and high temperature.
Uncovering the adult morphology of the forearm bones from the Sima de los Huesos Site in Atapuerca (Spain), with comments on biomechanical features
Authors: Rodríguez Laura , García‐González Rebeca , Arsuaga Juan Luis , Carretero José‐Miguel 
Published: June 2023

AbstractThe forearm skeleton is composed of two bones: the radius and the ulna. This is closely related to manipulative movements. The ulna is part of the elbow joint, whereas the radius and ulna together with the scaphoid and lunate bones, form the wrist joints. Thus, morphofunctional analysis of the adult Sima de los Huesos (SH) forearm bones, provides clues about manipulative activities in one Pleistocene population. From 1976 to the present, over 7000 human fossils have been recovered from the SH site. The radial sample comprised 98 labeled fragments, of which 49 belonged to adult individuals, representing at least 7 individuals. The ulnar sample included 31 labeled adult fossils representing at least nine individuals. In this study, we describe the SH radii and ulnae and analyze their functional implications for manipulative and forearm movements. We confirmed that the SH radii are long and curved, with variations in robusticity and radial tuberosity orientation. The SH ulnae are characterized by an anteriorly oriented trochlear notch, a massive olecranon process, an obliquely oriented radial notch, a blunt and short supinator crest, a gracile and curved diaphysis, and a round and anteriorly oriented pronator crests. In general, they exhibit Neanderthal morphology. The SH collection provides a unique opportunity to conduct morphological analyses of these bones in the Middle Pleistocene population.
Multitargeting in cardioprotection: An example of biaromatic compounds
Authors: Mokrov Grigory V. 
Published: June 2023

AbstractA multitarget drug design approach is actively developing in modern medicinal chemistry and pharmacology, especially with regard to multifactorial diseases such as cardiovascular diseases, cancer, and neurodegenerative diseases. A detailed study of many well‐known drugs developed within the single‐target approach also often reveals additional mechanisms of their real pharmacological action. One of the multitarget drug design approaches can be the identification of the basic pharmacophore models corresponding to a wide range of the required target ligands. Among such models in the group of cardioprotectors is the linked biaromatic system. This review develops the concept of a “basic pharmacophore” using the biaromatic pharmacophore of cardioprotectors as an example. It presents an analysis of possible biological targets for compounds corresponding to the biaromatic pharmacophore and an analysis of the spectrum of biological targets for the five most known and most studied cardioprotective drugs corresponding to this model, and their involvement in the biological effects of these drugs.