bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, controlled trial of a mixed early start Denver model for toddlers and preschoolers with autism
Authors: Yang Yanyan , Wang Hongan , Xu Haiping , Yao Meiling , Yu Dongchuan 
Published: August 2023

AbstractThe early start Denver model (ESDM) has been extensively studied as a promising early intervention approach for young children with autism spectrum disorder (ASD). Various methodological drawbacks from earlier ESDM investigations must be rectified to expand the application scopes. For this purpose, the present study recruited a very large sample of 249 autistic children (aged 24–47 months), and used a randomized controlled design to compare outcomes from a mixed ESDM (M‐ESDM) intervention with a mixed discrete trial teaching (M‐DTT) intervention which remains one of the most commonly‐used programming for early intervention. Over the course of a 12‐week period, both groups (i.e., M‐ESDM and M‐DTT groups) received 25 h of intensive intervention per week using individual, group, and parent coaching techniques. Findings showed that: (i) the M‐ESDM significantly outperformed the M‐DTT in enhancing children's developmental abilities in gross motor and personal‐social skills for toddlers and preschoolers, as well as in language for preschoolers with mild/moderate ASD and toddlers; and (ii) the M‐ESDM dramatically reduced the severity of autistic symptoms in toddlers with severe ASD only, when compared to the M‐DTT. However, the M‐ESDM did not outperform the M‐DTT in terms of improving children's developmental abilities in adaptability and fine motor for toddlers and preschoolers, as well as in language for preschoolers with severe ASD. In addition, when compared to the M‐DTT, the M‐ESDM did not show an advantage in reducing the severity of autistic symptoms in toddlers with mild/moderate ASD and preschoolers. Clinical Trial Registration: Chinese Clinical Trial Registry. Registration number ChiCTR200039492.
A New Nickel/cobalt Borate as High‐Performance Anode Material for Sodium‐Ion Batteries
Authors: Xu Beibei , Cao Yongjie , Xu Jie , Zhao Deqiang , Wang Nan , Wang Baofeng 
Published: August 2023

AbstractSodium‐ion batteries (SIBs) are widely considered a promising option for large‐scale energy storage, but their energy density is limited by the low specific capacity anode material. Herein, we synthesize a compound, namely Co2Ni(BO3)2 (denoted as CNBO), which is firstly served as an anode material in SIBs. The in‐situ X‐ray diffraction (XRD) and ex‐situ X‐ray photoelectron spectroscopy (XPS) are conducted to elucidate the Na‐ion storage mechanism, which involves a conversion reaction with a theoretical specific capacity of 546 mAh g−1. As anode material for SIBs, CNBO exhibits a high initial reversible specific capacity of 544.2 mAh g−1 and maintains good cycling performance (319.2 mAh g−1 for 80 cycles at 0.2 A g−1) with remarkable rate capabilities (235.3 mAh g−1 at 2 A g−1). Furthermore, a sodium‐ion full cell using CNBO as the anode and Na3V2(PO4)3 as the cathode (CNBO||NVP) can attain a maximum energy density of 146 Wh kg−1 with excellent cycle stability and rate capabilities. This work presents the possibilities for developing metal borate‐based materials for efficient sodium‐ion storage.
Affective debiasing: Focusing on emotion during consumption attenuates attribute framing effects
Authors: Poor Morgan , Isaac Mathew S. 
Published: August 2023

AbstractOne of the most pervasive findings in attribute framing research is the valence consistent shift; that is, positively valenced frames (e.g., 95% natural ingredients) are preferred over semantically equivalent but negatively valenced frames (e.g., 5% artificial ingredients). Despite the robustness of this finding, it has primarily been observed in judgments of prospective or hypothetical consumption. When valenced frames are presented during or immediately prior to an actual consumption experience, evidence for the valence consistent shift is weaker and less conclusive. In the present research, we propose and show that individuals' susceptibility to a valenced frame encountered around the time of a related consumption experience depends on whether they focus primarily on their cognitions or their emotions during the experience. Specifically, five experiments provide evidence that the valence consistent shift is attenuated in visual, auditory, and (simulated) gustatory consumption contexts when individuals are prompted to rely more on affective (vs. cognitive) inputs. Implications for both theory and practice are discussed.
Green synthesis‐assisted copper nanoparticles using Aegle marmelos leaves extract: physical, optical, and antimicrobial properties
Authors: Tanwar Shruti , Parauha Yatish Ratn , There Yogesh , Dhoble Sanjay Janaraoji 
Published: August 2023

AbstractIn the present report, Aegle marmelos leaf powder was used to synthesize copper nanoparticles (CuNPs) using a simple and cost‐effective method. A. marmelos leaves have various medicinal uses including for the treatment of diarrhoea, constipation, diabetes, cholera, skin diseases, earache, blood purification, heart problems, and so on. The plant biomolecules induce the reduction of Cu2+ ions to CuNPs and also act as a capping and stabilizing agent. The formation of CuNPs was confirmed using photoluminescence (PL) excitation and emission spectra on a Shimadzu RF‐5301 PC spectrofluorophotometer and the absorbance spectra of a UV–visible spectrophotometer at different stages during the synthesis process. In addition, other properties of synthesized CuNPs were also investigated using X‐ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy techniques. The average size of the synthesized CuNPs was in the range 20–40 nm. Furthermore, the synthesized NPs were also considered for an antimicrobial study against Gram‐positive Staphylococcus aureus and Proteus, and Gram‐negative Escherichia coli and Salmonella spp. using the agar well diffusion method. The zone of inhibition against the Gram‐positive bacteria was greater than the zone of inhibition against the Gram‐negative bacteria. These investigation results suggest that synthesized NPs are promising nanomaterials for use as antimicrobial agents.
Mesoporous polydopamine nanoplatforms loaded with calcium ascorbate for amplified oxidation and photothermal combination cancer therapy
Authors: Zhang Meng , Ran Siyi , Yin Xueling , Zhang Jiting , Sun Xiao , Sun Wei , Zhu Zhihong 
Published: August 2023

AbstractDestruction of cellular redox homeostasis to induce cancer cell apoptosis is an emerging tumor therapeutic strategy. To achieve this goal, elevating exogenous oxidative stress or impairing the antioxidant defense system of cancer cells is an effective method. Herein, we firstly report a biocompatible and versatile nanoplatform based on mesoporous polydopamine (MpDA) nanoparticles and a phase‐change material (PCM) for delivering calcium ascorbate (Vc‐Ca), simultaneously enabling combination therapy of hyperthermia, reactive oxygen species (ROS) generation, and suppression of tumor antioxidant capability. In this design, Vc‐Ca encapsulated in MpDA using PCM is controllably released due to the melting of PCM matrix in response to photothermal heating upon near‐infrared irradiation. Vc‐Ca is proved to be a pro‐oxidant that can promote the production of ROS (H2O2) in the tumor site. Remarkably, MpDA can not only act as a photothermal agent but also can break the redox balance of cancer cells through depleting the primary antioxidant glutathione, thus amplifying Vc‐Ca‐mediated oxidative therapy. Both in vitro and in vivo results demonstrate the significantly enhanced antitumor activity of boosted ROS combined with local hyperthermia. This study highlights the potential applications of Vc‐Ca in cancer treatment, and the prepared multifunctional nanoplatform provides a novel paradigm for high‐efficiency oxidation‐photothermal therapy.
The map of bone metastasis in nasopharyngeal carcinoma: A real‐world study
Authors: Luo Dong‐Hua , Li Jia‐Xin , Guo Wan‐Ping , Guo Chen‐Guang , Meng Xiao‐Han , Xie Pei‐Jun , Lin Jie‐Yi , Mo Hao‐Yuan , Zhang Qun , Chen Yong , Shen Guo‐Ping 
Published: August 2023

AbstractObjectivesThe aim of this study was to compare the metastatic patterns of synchronous bone metastasis (SBM) and metachronous bone metastasis (MBM) in nasopharyngeal carcinoma (NPC).MethodsThis study included bone metastases in NPC patients from 2005 to 2016 in a Chinese hospital. Cohort 1 was collected from 2005 to 2010 for discovery, and Cohort 2 from 2011 to 2016 for validation. The chi‐squared test, Wilcoxon rank sum test, and Kaplan–Meier technique were used to compare site, time, and survival between cohorts 1 and 2. Prognostic factors were analyzed using univariate or multivariate Cox regression.ResultsCohort 1 had 112 individuals with SBM and 394 with MBM, and cohort 2 had 328 with SBM and 307 with MBM. The thoracic vertebra was the most frequently affected site of metastasis. Patients with SBM more often had metastasis to the cervical vertebrae compared with patients with MBM (34.5% vs. 22.3%, p < 0.05). Patients with SBM had better overall survival (42.2 months, 95% CI: 33.9–50.7) than patients with MBM (24.9 months, 95% CI: 22.2–28.7). Age at bone metastasis detection, metastasis to other organs, and more bone metastasis locations were associated with worse prognosis. The majority of MBMs occurred at 7 to 18 months after NPC diagnosis.ConclusionRadiotherapy does not modify the metastatic patterns of NPC bone metastases. Patients with SBM tend to have metastasis to the cervical vertebra, which is close to the nasopharynx. Paying more attention to bone metastases during follow‐up in the first 2 years after an NPC diagnosis.
Immune‐related adverse events and outcomes among pan‐cancer patients receiving immune checkpoint inhibitors: A monocentric real‐world observational study
Authors: Ge Xiaoxiao , Jiang Weiping , Li Hongqing , Wu Yanxu , Li Xiangyang , Cui Shaohua 
Published: August 2023

AbstractBackgroundReal‐world evidence on immune‐related adverse events (irAEs) are relatively insufficient. Herein patterns and outcomes of irAEs after administration of anti‐programmed cell death 1 (PD‐1) and its legend 1 (PD‐L1) antibodies were investigated.MethodsPatients treated with anti‐PD‐1/PD‐L1 drugs from January 2018 to September 2021 at Huadong Hospital, Fudan University were included. Common Terminology Criteria for Adverse Events (CTCAE) was used for irAEs evaluation. The primary endpoints were the clinical description of irAEs.ResultsTwo hundred and forty‐one solid tumor patients were included, with lung cancer as the most common tumor type (56%). 187 (77.6%) patients presented any kind of irAEs. The median time to any irAE onset was 28 (95% CI 24–32) days. Skin toxicities are the most common irAEs (46.1%) and the irAEs (36.5%) occurred earliest after immune‐checkpoint inhibitors. The most frequently occurred all‐grade irAEs were rash (23.7%), myelosuppression (20.7%), and hepatic injury (19.5%). 23 (9.5%) patients died of severe irAEs, which consists of 10 patients with pneumonitis, four colitis, four myocarditis, and one each for gastritis, pulmonary embolism, myelosuppression, hypophysitis, and encephalitis. Patients with any irAE onset had significantly longer progression‐free survival (PFS) (p = 0.013) and overall survival (OS) (p = 0.007), respectively, than patients without irAEs. In addition, patients with skin toxicities (p = 0.012) or blood toxicities (p = 0.015) had achieved a longer PFS, than those without corresponding toxitities, respectively.ConclusionMost irAEs are mild and manageable, while some irAEs can present at later time or can be life‐threatening, especially pneumonitis as we observed. Patients with any irAE onset may achieve a better prognosis than those without irAEs, and presentation of skin or blood toxicities will indicate a better PFS.
Social support and self‐efficacy serially mediate the association of strength of identification with text‐based crisis support line volunteers' compassion fatigue and compassion satisfaction
Authors: Donnellan Alanna , Bradshaw Daragh , McMahon Jennifer 
Published: August 2023

AbstractHelp‐line services provide a vital support to individuals experiencing mental or personal crisis. Recent years has seen a rise in both text‐based services as well as remote working conditions for those who offer help‐line services. Previous research has demonstrated positive and negative outcomes for individuals voluntarily offering support at crisis‐line services. However, few studies have focused on the mechanisms at work. The social identity approach offers one potential avenue for exploration. Specifically, individuals who meaningfully identify as a volunteer can unlock the benefits of the social cure. However, this pathway has not been tested for volunteers in remote working environments. The current study tested associations between identification with a crisis support organisation, well‐being outcomes, perceptions of social‐support, and self‐efficacy in remote text‐based services. This study collected data from 157 crisis‐support line volunteers in two remote‐working contexts. Results indicated a serial mediated indirect effect. Specifically, increased identification as a volunteer predicted increased perceptions of social support. In addition, social support predicted higher levels of self‐efficacy, resulting in increased levels of compassion satisfaction along with decreased levels of burnout, and secondary traumatic stress. Results emphasise the role of social identity and perceptions of social support in promoting positive outcomes for remote‐working volunteers.
Medicinal Chemistry Perspectives on Recent Advances in Src Kinase Inhibitors as a Potential Target for the Development of Anticancer Agents: Biological Profile, Selectivity, Structure‐Activity Relationship
Authors: Teli Ghanshyam , Pal Rohit , Maji Lalmohan , Sengupta Sindhuja , Raghavendra Nulgumnalli Manjunathaiah , Matada Gurubasavaraja Swamy Purawarga 
Published: August 2023

AbstractThe physiological Src proto‐oncogene is a protein tyrosine kinase receptor that served as the essential signaling pathway in different types of cancer. Src kinase receptor is divided into different domains: a unique domain, an SH3 domain, an SH2 domain, a protein tyrosine kinase domain, and a regulatory tail, which runs from the N‐terminus to the C‐terminus. Src kinase inhibitors bind in the kinase domain and are activated by phosphorylation. The etiology of cancer involved various signaling pathways and Src signaling pathways are also involved in those clusters. Although the dysregulation of Src kinase resulted in cancer being discovered in the late 19th century it is still considered a cult pathway because it is not much explored by different medicinal chemists and oncologists. The Src kinase regulated through different kinase pathways (MAPK, PI3K/Akt/mTOR, JAK/STAT3, Hippo kinase, PEAK1, and Rho/ROCK pathways) and proceeded downstream signaling to conduct cell proliferation, angiogenesis, migration, invasion, and metastasis of cancer cells. There are numerous FDA‐approved drugs flooded the market but still, there is a huge demand for the creation of novel anticancer drugs. As the existing drugs are accompanied by several adverse effects and drug resistance due to rapid mutation in proteins. In this review, we have elaborated about the structure and activation of Src kinase, as well as the development of Src kinase inhibitors. Our group also provided a comprehensive overview of Src inhibitors throughout the last two decades, including their biological activity, structure‐activity relationship, and Src kinase selectivity. The Src binding pocket has been investigated in detail to better comprehend the interaction of Src inhibitors with amino acid residues. We have strengthened the literature with our contribution in terms of molecular docking and ADMET studies of top compounds. We hope that the current analysis will be a useful resource for researchers and provide glimpse of direction toward the design and development of more specific, selective, and potent Src kinase inhibitors.
Discovery of Four New Compounds from Macropanax membranifolius and Their Cytotoxic Activity
Authors: Hang Pham Thi , Hue Nguyen Thi , Nam Nguyen Hoang , Tuan Nguyen Le , Cuong Pham Van , Vuong Nguyen Quoc , Hang Dan Thi Thuy , Tai Bui Huu , Kiem Phan Van 
Published: August 2023

AbstractA phytochemical investigation of the methanolic extract of the Macropanax membranifolius C.B. Shang leaves led to the isolation of three new flavans, (2R,3R)‐4′‐O‐methylcatechin 5‐O‐β‐D‐glucopyranoside (1), (2S,3S)‐4′‐O‐methylcatechin 5‐O‐β‐D‐glucopyranoside (2), (2S,3R)‐4′‐O‐methylcatechin 5‐O‐β‐D‐glucopyranoside (3), one new triterpene glycoside 3‐O‐β‐D‐xylopyranosyl‐(1→6)‐[β‐D‐xylopyranosyl‐(1→2)]‐β‐D‐glucopyranosyl‐oleanolic acid 28‐O‐β‐D‐glucopyranoside (4), together with nine known compounds (5‐13). Their chemical structures were elucidated based on HR‐ESI‐MS, NMR spectroscopic data. The absolute configurations of compounds 1–3 were established by electronic circular dichroism (ECD) spectra. At concentration of 20 μM, compounds 1–13 showed the percentages of dead cell in the range of 2.14 % to 33.61 % against KB, HepG2, HL60, P388, HT29, and MCF7 cancerous cell lines by SRB assay.
Type 1 citrullinemia patient with Brugada pattern undergoing general anesthesia for dental extractions: A case report
Authors: Dell’Olio Fabio , Lorusso Pantaleo , Siciliani Rosaria Arianna , Massaro Maria , Barile Giuseppe , Tempesta Angela , Grasso Salvatore , Favia Gianfranco , Limongelli Luisa 
Published: August 2023

Key Clinical MessageThe perioperative control of ammonia, reduction of stress, and administration of drugs tolerated in type 1 citrullinemia and Brugada pattern allowed the successful and uneventful management of general anesthesia in the study patient.AbstractThe aim of this study was to report the targeted perioperative management of general anesthesia (GA) adopted for dental extractions in a rare patient with type 1 citrullinemia and Brugada pattern. A male, Caucasian, adult type 1 citrullinemia patient needed dental extractions under GA. The medical history showed neurodevelopmental impairment, growth retardation, epilepsy, and a Type 2 Brugada electrocardiographic pattern in the second precordial lead. The authors focused the anesthesiologic protocol on the prevention of hyperammonemia and fatal arrhythmias. Changes in diet and 10% glucose solution administration prevented protein catabolism due to the fasting period (ammonia was 44 μmol/L preoperatively and 46 μmol/L postoperatively; glycemia was 120 g/dL preoperatively and 153 g/dL postoperatively). The patient received a continuous electrocardiogram, noninvasive blood pressure, pulse oximeter, entropy monitoring, train‐of‐four monitoring, and external biphasic defibrillator pads. Midazolam, remifentanil, and dexamethasone were administered for pre‐anesthesia; thiopental and rocuronium for induction; remifentanil and desflurane for maintenance; sugammadex for decurarization. After the intraligamentary injection of lidocaine 2% with epinephrine 1:100,000 for local anesthesia, the patient developed a transient Type 1 Brugada pattern that lasted a few minutes. The whole procedure lasted 30 min. The patient's discharge to ward occurred 3 h after the end of GA. The perioperative management of ammonia, reduction of stress, and administration of drugs tolerated in Type 1 citrullinemia and Brugada pattern allowed the successful and uneventful administration of GA in the study patient.
Time‐resolved DRIFT Spectroscopy Study of Carbonaceous Intermediates during the Water Gas Shift Reaction over Au/Ceria Catalyst
Authors: Vecchietti Julia , Belletti Gustavo , Quaino Paola , Bonivardi Adrian , Collins Sebastián 
Published: August 2023

AbstractChemCatChem homepage for more articles in the collection. The mechanism of the low‐temperature water gas shift reaction (LTWGS) on an Au/CeO2 catalyst was investigated by means of in situ diffuse reflectance infrared (DRIFT) spectroscopy. Under steady‐state LTWGS reaction (373–623 K), the catalyst is partially reduced, and signals from carbonate/formate dominates the infrared spectra. Time‐resolved pulse of CO experiment under a constant partial pressure of water at 423 K indicates that Ce4+ can be reduced to Ce3+ and that formate (HCOO) species cannot be directly related to the CO2 production. Further information was obtained by performing modulation excitation spectroscopy (MES) experiments coupled with a phase‐sensitive detection (PSD) method. Under periodic modulation of the CO partial pressure while keeping the H2O concentration constant, most of the intense bands of carbonate and formate remained constant, indicating that these species are only spectators. The same is observed for the concentration of Ce3+. Conversely, signals in‐phase with the conversion of CO to CO2 are observed and assigned to carboxyl [C(O)OH] and carboxylate (CO2δ−) species, while some monodentate formate (m‐HCOO) also changes but at a lower rate. A plausible associative reaction mechanism where carboxyl/carboxylate are key intermediates is postulated.
The public–private partnerships in healthcare sector in China
Authors: Liu Bo , Shi Leiyu , Min Hanyi , Liang Hailun , Dong Jiahong 
Published: August 2023

AbstractThis manuscript is a narrative review on experience in the healthcare public–private partnerships (PPP) field project in China. The PPP model allows healthcare officials to share the risk of building new facilities with the private sector. The objective of this study is to evaluate and to review the PPP of healthcare sector in China, and to investigate the critical success factors and best practice of PPP. We adapted the PPP evaluation framework of the World Bank Independent Evaluation Group as our conceptual framework to summarize the literatures. The current study systematically reviewed the evolution and current status of public and private hospitals development in China, and to investigate factors related to the successful and less successful deployment and performance of PPP in the healthcare sector of China, and to develop best practice models of PPP among hospitals of China. We found that the PPP organizations providing finance and political risk coverage, thus enabling specific PPP transactions to reach financial closure—potentially setting demonstration effects. Such PPPs may then contribute to improving access to infrastructure and social services, which drives economic growth and other optimal outcomes.
Effect of Copper Oxide Nanoparticles on the Performance of Polyvinyl Chloride Membranes
Authors: Khezraqa Homayun , Samiei Arian , Etemadi Habib , Salami-Kalajahi Mehdi 
Published: August 2023

AbstractPolyvinyl chloride (PVC)/copper oxide (CuO) nanocomposite membranes were fabricated at different CuO nanoparticles loading levels using the phase inversion method. The fabricated membranes were tested through two filtration cycles in a submerged membrane system to remove bovine serum albumin (BSA) from water. Results showed that the hydrophilicity and porosity of the nanocomposite membranes were enhanced with an increase of CuO nanoparticles loading. The field emission electron microscopy images from the membrane surface demonstrated that the number and size of pores increased with addition of CuO nanoparticles. The atomic force microscopy test displayed that all nanocomposite membranes showed lower surface roughness in comparison to neat PVC membranes. The obtained results from membrane performance indicated that the irreversible fouling ratio for neat PVC membranes in the first and second cycles of filtration decreased for PVC/CuO‐1.5 membranes. Compared with the neat PVC membrane, the membrane containing CuO exhibited better capabilities such as the enhanced permeation flux, higher BSA rejection rate, and better antifouling properties.