bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of telehealth cardiac rehabilitation programs on health outcomes of patients with coronary heart diseases: an umbrella review
Authors: Shi W , Green H , Sikhosana N , Fernandez R 
Published: July 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Cardiac rehabilitation using Telehealth has increased rapidly over the past two decades and has become the predominant mode of delivery during the Covid 19 pandemic. Numerous systematic reviews have been conducted summarizing the evidence on the advantages and disadvantages of cardiac rehabilitation using Telehealth on various cardiovascular risk factors and health-related behaviours.

Purpose
To conduct an umbrella review summarizing the evidence from existing systematic reviews of telehealth cardiac rehabilitation on health outcomes of patients with coronary heart disease (CHD).

Methods
An umbrella review of systematic reviews was undertaken in accordance with the PRISMA and JBI guidelines. A systematic search was conducted in Medline, APA PsycInfo, Embase, CINAHL, Web of Science, Cochrane database of systematic reviews, JBI evidence synthesis, Epistemonikos, and PROSPERO, searching for systematic reviews published from 1990 to current and was limited to the language source of English and Chinese. Outcomes of interest were modifiable CHD risk factors, psychosocial outcomes, and other secondary outcomes. Study quality was appraised using the JBI checklist for systematic reviews. A narrative analysis was conducted, and meta-analysis results were synthesized.

Results
From 1,301 identified reviews, 13 systematic reviews (10 meta-analyses) comprised 132 primary studies conducted in 28 countries. All the included reviews have high quality, with scores ranging from 73% to 100%. Findings to the modifiable risk factors remained inconclusive, except solid evidence was found in the significant improvement in physical activity level and behaviours from telehealth interventions, exercise capacity from m-health only and web-based only interventions, and medication adherence from m-health interventions.

Conclusion
Telehealth cardiac rehabilitation programs, work adjunct or in addition to traditional cardiac rehabilitation and standard care, are effective in improving modifiable CHD risk factors, particularly in physical activity. In addition, it does not increase the incidence in terms of mortality, adverse events, hospital readmission and revascularisation.
QGenome: a smart app-based clinical decision aid for inherited cardiac conditions
Authors: Bueser T , Wafik M , Carley H , Bastiaenen R , Wierzbicki T , Frampton K , Kenney A , Bustillo B , Tripathi V , Tomlinson C , Cross S , Kulkarni A , Robert L 
Published: July 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public Institution(s). Main funding source(s): Guy’s and St Thomas’ Charity
South East Genomic Medicine Service Alliance

Background
QGenome is a smart application designed by a Regional Genetics service, in partnership with a Genomic Medicine Service Alliance (GMSA) and a technology company. The aims were to facilitate streamlined genomic testing, risk assessment, and referral guidance to relevant healthcare professionals in primary, secondary, and tertiary care settings; and to provide equity of "Genomics care" for patients across the UK, through standardized genomic testing and referral pathways.
Due to high clinical demand, and following a design workshop with stakeholders, the initial version of QGenome was implemented for Cancer Genomics pathways. The scope has been extended to include workflows for Cardiology and Renal Genomics. The current Inherited Cardiac Conditions (ICC) workflow includes initial genomic testing/risk assessment pathways developed for familial hypercholesterolaemia, long QT syndrome, and vascular Ehlers Danlos Syndrome (vEDS).

Methods
For each clinical indication/condition, QGenome provides workflow assessments to determine eligibility for genomic testing and/or specialist tertiary referral. The workflow takes the user through a series of questions about their patient’s personal, past medical, and family history in a user-friendly format, to assess inherited susceptibility to disease.
Eligibility criteria are derived from the UK National Genomic Test Directory, published literature and guidance from relevant advisory board working groups.
The app can be used to find relevant forms, save reports, and activate referrals to specialist services or genetics clinics. QGenome is freely available on iOS, android and web-based platforms.

Results
The ICC workflows are demonstrated through the vEDS case studies (Figure).

Conclusion
QGenome offers a quick, efficient clinical decision tool for healthcare professionals, including cardiovascular nurses and allied professionals, in busy clinical settings, to differentiate between patients with likely sporadic cardiac disease and those with probable genetic/hereditary susceptibility for ICC.
Association of heart failure symptoms burden with physical well-being: exploring the roles of self-care and sleep quality using a moderated-mediation analysis
Authors: Durante A , Di Nitto M , Juarez-Vela R , Chung M L 
Published: July 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Patients with heart failure (HF) commonly experience symptom burden. Symptoms such as breathlessness, fatigue, and fluid retention can have an important impact on the patient's daily activities and overall health. Given the evidence of symptoms' negative impact on the quality of life in patients with HF, self-care maintenance is critical. However, there is a paucity of knowledge regards the role played by self-care and the quality of sleep in this population.

Purpose
To explore the association between HF symptoms burden and quality of life (i.e., physical well-being) and how the association was moderated by levels of self-care maintenance and mediated by sleep quality.

Methods
This was a secondary analysis of a single-center cross-sectional study conducted in Spain, between February and December 2017. Symptom burden was measured using the Heart Failure Somatic Perception Scale (HFSPS), and quality of life was assessed using the physical well-being subscale of the 12-Item Short Form Survey (SF-12). Self-care was assessed using the self-care maintenance subscale of the Self-Care Heart Failure Index (SCHFI) (version 6.2), and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). A moderated-mediation analysis was conducted to explore the role of self-care as a moderator and sleep quality as a mediator in the association using SPSS PROCESS macro with 5000 bootstrap samples, adjusted for age, sex, Body Mass Index (BMI) and NYHA covariates.

Results
A total of 178 patients completed the questionnaires. The patients were older (mean age 80, SD ±8,9) with a mean BMI of 29 (SD ± 5,5). About of patients were males (50.6%) and NYHA class 1 or 2 (58.4%). Symptom burden was negatively associated with sleep quality (B = -.104, t(1, 176) = -7.7675, p = &lt;,001), which was positively associated with physical well-being (B = .5664, t(1, 176) = 2.9810, p = .003). The association between symptom burden and physical well-being was moderated by self-care maintenance (interaction value= -.0038, t(1, 176) = -2.0022, p = .047). In the moderated mediation analysis (Figure 1), we found that the direct effect strength of burden symptom on physical well-being was different by the level of self-care maintenance (Johnson-Neyman value= 32.3560, low = 15.1685 high = 84.8315). There was also a significant indirect effect of symptom burden on physical well-being through sleep quality adjusted (B = -.0589, 95% CI [ -.1001, -.0230]).

Conclusion
Self-care maintenance moderates the association symptom burden and physical well-being, while sleep quality acts as a mediator in the association. Improving quality of life, while empowering self-care, should also consider an evaluation and improving stretegies of sleep quality as it impacts physical quality of life.Moderated-mediation analysis
Workplace violence against cardiovascular nurses during Covid-19 pandemic
Authors: Bagnasco A , Catania G , Pagnucci N , Alvaro R , Cicolini G , Dal Molin A , Lancia L , Lusignani M , Mecugni D , Motta P C , Watson R , Hayter M , Napolitano F , Zanini M , Sasso L 
Published: July 2023

Abstract

Funding Acknowledgements
Type of funding sources: Other. Main funding source(s): The National Federation of Orders for Nursing Professions (FNOPI - Italia)

Background
Workplace violence (WPV) impacts negatively both healthcare workers and healthcare organizations. Nurses are the most exposed healthcare workers to vertical WPV, also during the COVID-19 pandemic.

Purpose
Describing the WPV against nurses and its predictive factors in cardiovascular settings during COVID-19 pandemic in Italy.

Methods
This is a secondary analysis conducted in cardiovascular hospital settings from a larger national study between January and April 2021. Data were collected through the Practice Environment Scale of the Nursing Work Index (PES-NWI; Likert scale 1 to 4) and the adapted version of the Violence in Emergency Nursing and Triage (VENT) Questionnaire. Descriptive and logistic regression analyses were conducted.

Results
The analysis was conducted on 360 cardiovascular nurses (76.7% female; mean age 42.6 years, SD 10.8). Thirty per cent (n=108) of them reported WPV in last year and/or last week and 14.2% (n=51) only in last week. The number of patients was higher for nurses with WPV (mean difference [MD] +1.9; p = .030). The work environment was significantly worse for nurses with WPV: mean PES-NWI composite score (MD -0.2; p&lt;.001); PES-NWI subscales: staffing and resource adequacy (MD -0.3; p&lt;.001); nursing foundations for quality of care (MD -0.2; p = .005); nurse participation in hospital affairs (MD -0.3; p&lt;.001); physician-nurse relationship (MD -0.2; p = .004). Multiple linear regression demonstrated that the risk of WPV increases when a clear nursing philosophy was not completely implemented in cardiovascular setting (odds ratio [OR] 5.29; 95% confidence interval [CI], 1.07-26.05; p = .040) and the nurses restrain patients (OR 2.49; 95% CI, 1.04-5.97, p = .041). The risk of WPV decreases when protectives glasses were present (OR 0.36; 95% CI 0.19-0.70, p = .003).

Conclusion
Public healthcare services should reduce WPV by investing in improving the nurse work environment. Integrated and multimodal programs of prevention and management of WPV are useful to address it.
Evaluation of an educational intervention into an emergency department to improve diagnosis and early treatment in STEMI
Authors: Berga Congost G , Martinez Momblan M A , Garcimartin Cerezo P , Valverde Bernal J , Castello Fosch N , Garcia Picart J , Puig Campmany M , Alvarez Albarran M T , Lazzari R , Mesa Rico R , Marques Sule E , Brugaletta S 
Published: July 2023

Abstract

Funding Acknowledgements
Type of funding sources: Public grant(s) – National budget only. Main funding source(s): The Government of Catalonia (Spain) provided funding for this research, with a grant issued in 2019 within the framework of the Strategic Health Research and Innovation Plan (PERIS) 2016-2020 to Gemma Berga Congost

Background
Clinical guidelines recommend some quality indicators to measure the effectiveness of ST-elevation acute myocardial infarction (STEMI) treatment. Adherence to these indicators is complex in atypical presentations, due to delayed diagnosis. Ongoing training is a useful tool in improving STEMI diagnosis.
Our aim was to evaluate the impact of a training intervention incorporating clinical simulation tools for emergency triage nurses and doctors on STEMI diagnosis.

Methods
a prospective observational study was carry out in a STEMI hub hospital. All emergency professionals gave their consent and were included into the training. A theoretical-practical training activity with clinical simulation was designed and implemented in June 2021. Pre and post knowledge were assessed using a questionnaire validates by a group of experts and a validated satisfaction survey was performed.

Results
20 professionals were included, 16 nurses and 4 physicians. 95% viewed all the online content and participated into the face-to-face training. All fulfilled the questionnaire pre-training and 70% the post-training. A 50% increase in the knowledge, evaluated by questionnaire, was observed. 80% of the participants evaluated as satisfactory the intervention with an excellent rating was obtained.

Conclusion
There was a high degree of participation into the training. The knowledge of the participants increased by more than 50% and their satisfaction with the educational intervention was excellent. Future studies are required to assess the impact of training on STEMI response time, clinical outcomes and mortality.
Fasting before coronary angiography: a scoping review protocol
Authors: Monteiro Teixeira C A , Rodrigues D 
Published: July 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background/Introduction
Nowadays, coronary heart disease is one of the major threats to a long and healthy life. The widespread demand for a tool to assess coronary artery anatomy has made coronary angiography a mainstream procedure. As with many other procedures, a fasting period before and after it is required. Despite this, the current practice does not rely on any study and therefore, if the procedure is to be delayed, which, unfortunately, often occurs, this might have major implications on the patient’s well-being and safety.

Purpose
To map the literature on fasting before coronary angiography.

Methods
This review follows the Joanna Briggs Institute methodology of scoping reviews, thus two reviewers independently will perform the study selection regarding their eligibility. Data synthesis will be presented in tabular form and a narrative summary that align with the review's objective. Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension to scoping reviews guidelines will be used to report the results. An initial limited search of MEDLINE (PubMed) and CINAHL (EBSCO) will be undertaken, followed by a search on the following databases: the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and Scopus. Additionally, to further increase the evidence available, unpublished studies will be included, and a search on: OpenGrey (OpenGrey.eu), DART-Europe and publications of interventional cardiology reference sites will be conducted.

Results
Mapping the evidence will contribute to identifying the focus of the study.

Conclusion
It is expected that this review serves as a gateway for the development of future studies and guidelines which could improve daily clinical practice.
Metaphor—A workflow for streamlined assembly and binning of metagenomes
Authors: Salazar Vinícius W , Shaban Babak , Quiroga Maria del Mar , Turnbull Robert , Tescari Edoardo , Rossetto Marcelino Vanessa , Verbruggen Heroen , Lê Cao Kim-Anh 
Published: July 2023

Abstract
Recent advances in bioinformatics and high-throughput sequencing have enabled the large-scale recovery of genomes from metagenomes. This has the potential to bring important insights as researchers can bypass cultivation and analyze genomes sourced directly from environmental samples. There are, however, technical challenges associated with this process, most notably the complexity of computational workflows required to process metagenomic data, which include dozens of bioinformatics software tools, each with their own set of customizable parameters that affect the final output of the workflow. At the core of these workflows are the processes of assembly—combining the short-input reads into longer, contiguous fragments (contigs)—and binning, clustering these contigs into individual genome bins. The limitations of assembly and binning algorithms also pose different challenges depending on the selected strategy to execute them. Both of these processes can be done for each sample separately or by pooling together multiple samples to leverage information from a combination of samples. Here we present Metaphor, a fully automated workflow for genome-resolved metagenomics (GRM). Metaphor differs from existing GRM workflows by offering flexible approaches for the assembly and binning of the input data and by combining multiple binning algorithms with a bin refinement step to achieve high-quality genome bins. Moreover, Metaphor generates reports to evaluate the performance of the workflow. We showcase the functionality of Metaphor on different synthetic datasets and the impact of available assembly and binning strategies on the final results.
Thermal structure beneath Changbaishan Volcano, northeastern Asia: new insights from temperature logging and numerical modelling
Authors: Jiang Guangzheng , Hu Shengbiao , Cui Tianri , Qian Cheng , Liu Feng , Zhang Chao , Wang Zhuting , Wang Yibo , Hou Tong , Tian Yuntao 
Published: July 2023

SUMMARY
Changbaishan Volcano is considered one of the most hazardous active volcanic fields in northeastern Asia, and it has been the subject of increasing concern due to its unrest from 2002 to 2006. The physical conditions of magma chambers in the crust, particularly temperature and pressure, are crucial factors that determine the tempo and magnitude of volcanic eruptions, which are closely linked to potential hazards. However, the lithospheric thermal structure, which strongly influences rheological behaviour and melting, has been poorly studied. We conducted direct geothermal measurements and numerical forward modelling to address this issue to confirm whether a crustal magma chamber lies beneath the caldera as in earlier geophysical interpretations. We first reported four heat-flow data sets in Changbaishan Volcano. The research findings indicate that the heat flow value near the Tianchi caldera is remarkably high, at 270±16 mW m−2. As the distance from the caldera increases, the heat flow gradually decreases to a normal continental heat flow value of 75 mW m−2. 3-D transient heat simulations with a magma cooling model and a continuous magma supply model demonstrate the thermal effect of the magma chamber. The best-fitting model for the Tianchi magma system is an ellipsoidal magma chamber with a depth of 8–14 km, a 20 km east–west axis and a 70 km north–south axis, supplied with magma from the asthenosphere for 2 Myr. The high surface heat flow and crustal temperatures suggest that magma is active beneath Changbaishan Volcano within the middle-upper crust, and volcanic reactivation could occur. Thus, further research on the lithospheric thermal structure is necessary to understand the potential volcanic hazards associated with Changbaishan Volcano.
Sourcing and Bias in the Study of Coups: Lessons from the Middle East
Authors: Ben Hammou Salah , Powell Jonathan , Sellers Bailey 
Published: July 2023

Abstract
The last two decades have seen an increased focus on reporting bias in large-N datasets. Research on coups d’etat has similarly increased given the availability of coup datasets. This essay argues that while the availability of such data has pushed scholarship forward, the data collection process behind these efforts remains plagued with limitations common to event datasets. Rather than building on what previous projects have accomplished, researchers have invariably developed “new” datasets that suffer from the same problems as earlier efforts. Specifically, we point to reliance on international news sources such as The New York Time and Keesing’s Record of World Events - without the adequate consultation of regional sources and expertise - as a source of concern. We explore this issue by assessing the coverage of coup events from three country cases from the post-colonial Middle East: Syria, Jordan, and Saudi Arabia. Our findings show that while existing data on successful and failed coups are largely adequate, scholars interested in coup plots and rumors will require a wider breadth of source material to identify such cases.
Weizmannia coagulans JA845 improves atherosclerosis induced by vitamin D3 and high-fat diet in rats through modulating lipid metabolism, oxidative stress, and endothelial vascular injury
Authors: Ma Liying , Zhao Zijian , Zhao Yujuan , Gao Yansong , Zhao Lei , Li Shengyu 
Published: July 2023

Abstract

Aims
Probiotics have been proved to be strongly linked to the occurrence and progression of atherosclerosis. This study aimed to investigate the improved effects and mechanisms underlying a potential probiotic, Weizmannia coagulans JA845, on atherosclerosis.

Methods and Results
Male Sprague–Dawley rats supported on a high-fat diet with vitamin D3 supplementation were subjected to W. coagulans JA845 treatment. W. coagulans JA845 obviously alleviated histological abnormalities of the abdominal aorta. After 6 weeks of W. coagulans JA845 administration, levels of TG, TC, LDL, ox-LDL, ROS, and MDA in the JA845 group decreased significantly, and those of HDL, GSH-Px, and SOD were markedly elevated. Treatment with W. coagulans JA845 also inhibited the secretion of ICAM-1 and VCAM-1 and regulated the plasma NO and eNOS content. In brief, administration of W. coagulans JA845 promoted the expression of the SIRT3/SOD2/FOXO3A pathway, inhibited the lipid metabolism pathway, SREBP-1c/FAS/DGAT2, and suppressed the JNK2/P38 MAPK/VEGF pathway implicated in endothelial injury.

Conclusions
These results indicated W. coagulans JA845 improved atherosclerosis by regulating lipid metabolism, antioxidative stress, and protecting against endothelial injury.
Are the NPS commonly used? An extensive investigation in Northern Italy based on hair analysis
Authors: Calvetti Cristina , Salomone Alberto , Verzeletti Andrea , Di Nardo Fabio , Begni Paola Maria Giulia , Vezzoli Sara 
Published: July 2023

Abstract
New psychoactive substances (NPS) are present on the Italian illicit markets, but data from the analysis of biological samples to evaluate their real consumption are rare. For this reason, an epidemiological study was carried out by means of a ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS-MS) method for the determination of 115 NPS on the keratin matrix. A total of 847 hair samples were collected in 2020 and 2021 and analyzed. The sample donors were in the age range of 18–40 years, from both genders, and were tested either for driving relicensing or for drug withdrawal monitoring. The UPLC–MS-MS system consisted of a Waters ACQUITY UPLC® I-Class, coupled with a Waters XEVO TQ-XS triple quadrupole mass spectrometer. The method was developed and fully validated according to international guidelines. Limits of detection were set as the minimum criterion to identify positive samples. Overall, 56 samples resulted positive for ketamine, 35 for norketamine, 6 for fentanyl, 3 for norfentanyl, 3 for 4-ANPP, 3 for MDMB-4en-PINACA, 2 for N,N-DMT, 2 for 5-chloro AB-PINACA, 1 for α-PHP and 1 for methcathinone. NPS were detected in a small part of samples (8.4%), which seems in contrast with their apparent wide diffusion in Italy, yet it is congruent with similar investigations based on hair analysis. Future studies will be performed to expand the investigated population, especially in terms of age and origin.