bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Report: Primary graft failure due to a reversed lenticule in Descemet Stripping Automated Endothelial Keratoplasty
Authors: Kate Anahita , Basu Sayan 
Published: January 2023

Introduction and importance: This report details the clinical features and management in a case of Descemet stripping automated endothelial keratoplasty (DSAEK) which had primary graft failure (PGF) due to an inverted yet attached lenticule. Presentation of case: A 66-year-old gentleman had poor visual recovery in the right eye after undergoing cataract surgery 12 years prior to presentation. The visual acuity was counting fingers and examination revealed endothelial decompensation. The patient underwent a DSAEK and postoperatively had a well attached lenticule. However, the cornea was edematous three weeks after the surgery and optical coherence tomography (OCT) revealed a reversed lenticule. The patient underwent a repeat DSAEK and had an uneventful postoperative course. The visual acuity was 20/40 after 7 months with a clear cornea and a well attached graft. Discussion: PGF is a rare complication following DSAEK which occurs due to poor endothelial function of the donor graft. Insertion of a reversed lenticule may get overlooked as a cause of PGF unless the graft edge profile is examined on an OCT scan. The graft in the current case was well attached despite its inverted position suggesting that graft adherence is perhaps not a function of the corneal endothelial pumps in isolation and may be driven by factors such as the intraocular pressure. Conclusion: A reversed DSAEK lenticule may have normal adherence to the host stroma and must be considered in cases with PGF. OCT of the graft edge is required for diagnosis before performing a repeat keratoplasty.
Protocol for a systematic review and meta-analysis on preoperative risk factors for failure after fixed sling implantation for post-prostatectomy stress urinary incontinence
Authors: Sacco Emilio , Marino Filippo , Gavi Filippo , Moretto Stefano , Gandi Carlo , Bientinesi Riccardo , Pierconti Francesco , Bassi Pierfrancesco 
Published: January 2023

Background: Post-prostatectomy urinary incontinence (PPI) is a bothersome complication affecting patients undergoing prostate surgery that in up 10% of cases will require an invasive treatment with fixed slings or artificial urinary sphincters (AUS). Although fixed slings have several advantages over AUS, failure rates after slings range between 15% and 45% while current knowledge of predictors of sling efficacy remains limited. By systematically combining and summarizing all relevant literature, the present review and meta-analysis aim to address this research need assessing the association between preoperative risk factors and sling failure. Methods: Studies pertaining to fixed synthetic male perineal slings as treatment for adult male suffering from PPI, will be included. A systematic search will be conducted in PubMED, Scopus, Web of Science and Cochrane databases, and in the reference lists of retrieved articles. Independent reviewers will conduct study selection and data extraction. Outcomes will include failure to achieve the continence cure and overall success (cure plus improvement), measured as per included studies. Exposures will include any preoperative variables evaluated for association with sling failure. The QUIPS tool will be used for study quality assessment and a random-effects DerSimonian-Laird model, with Hartung-Knapp adjustment, will be used to pool adjusted and unadjusted odds ratios separately. Sensitivity analysis will be performed using the leave-one-out methodology and subgroup meta-analyses based on pre-specified studies’ characteristics will be conducted to explain the heterogeneity. Certainty of evidence will be assessed according to GRADE methodology and review reporting will comply with the PRISMA-P statement. Discussion: By summarising all relevant literature in the field, our results will help to incorporate available evidence into clinical practice assisting healthcare professionals managing PPI patients in treatment decision-making. The present review will also provide researchers with the necessary, evidence-based groundwork to perform future high-quality prognostic studies in the field. Registration: CRD42022307160.
A scoping review of the evidence for the impact of pharmacological and non-pharmacological interventions on shift work related sleep disturbance in an occupational setting
Authors: Conway-Jones Rebecca , Dunlop Ella , Kyle Simon , Ray David , Roberts Nia , Farmer Andrew 
Published: January 2023

Background: Shift work is essential in society but can be detrimental to health and quality of life and is associated with decreased productivity and increased risk of accidents. Interventions to reduce these consequences are needed, but the extent and range of trial evidence for interventions for those most affected by their shift-work schedules is unclear. We therefore carried out a scoping review to assess the availability of evidence to inform the development and evaluation of future interventions. Methods: We aimed to identify clinical trials of any intervention for shift work-related sleep disturbance that included a comparator group, where the intervention was delivered in an occupational setting. We searched Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, CINAHL, EMBASE, Medline and Science Citation Index from inception to 30th March 2020 for relevant citations. Citations were screened by two independent reviewers, a third reviewer resolved disagreements. Data were extracted by two independent reviewers. Results: From 1250 unique citations, 14 studies met inclusion criteria for comparative trials of treatment in an occupational setting. There were five trials of hypnotics, five trials of stimulants, and four trials of non-pharmacological therapies (cognitive behavioural therapy, light therapy, aromatherapy and herbal medicine). Outcomes included sleep parameters, day-time sleepiness, and quality of life. There were no consistently reported outcomes across trials. Conclusions: Interventions fell into three distinct groups investigated in distinct time periods without progression from efficacy trials to wider-scale interventions. The lack of consistent patient-reported outcome measures limits synthesising findings. Some trials focussed on optimising sleep, others on reducing wake-time sleepiness. Adequately powered trials of existing interventions are needed, with the development and testing of novel combination treatments in patients with well-defined shift work sleep disorder. A core set of clinically relevant outcomes will develop and standardise the evidence-base for shift work sleep disorder.
Identifying and characterising Thrap3, Bclaf1 and Erh interactions using cross-linking mass spectrometry
Authors: Shcherbakova Liudmila , Pardo Mercedes , Roumeliotis Theodoros , Choudhary Jyoti 
Published: January 2023

Background: Cross-linking mass spectrometry (XL-MS) is a powerful technology capable of yielding structural insights across the complex cellular protein interaction network. However, up to date most of the studies utilising XL-MS to characterise individual protein complexes’ topology have been carried out on over-expressed or recombinant proteins, which might not accurately represent native cellular conditions. Methods: We performed XL-MS using MS-cleavable crosslinker disuccinimidyl sulfoxide (DSSO) after immunoprecipitation of endogenous BRG/Brahma-associated factors (BAF) complex and co-purifying proteins. Data are available via ProteomeXchange with identifier PXD027611. Results: Although we did not detect the expected enrichment of crosslinks within the BAF complex, we identified numerous crosslinks between three co-purifying proteins, namely Thrap3, Bclaf1 and Erh. Thrap3 and Bclaf1 are mostly disordered proteins for which no 3D structure is available. The XL data allowed us to map interaction surfaces on these proteins, which overlap with the non-disordered portions of both proteins. The identified XLs are in agreement with homology-modelled structures suggesting that the interaction surfaces are globular. Conclusions: Our data shows that MS-cleavable crosslinker DSSO can be used to characterise in detail the topology and interaction surfaces of endogenous protein complexes without the need for overexpression. We demonstrate that Bclaf1, Erh and Thrap3 interact closely with each other, suggesting they might form a novel complex, hereby referred to as TEB complex. This data can be exploited for modelling protein-protein docking to characterise the three-dimensional structure of the complex. Endogenous XL-MS might be challenging due to crosslinker accessibility, protein complex abundance or isolation efficiency, and require further optimisation for some complexes like the BAF complex to detect a substantial number of crosslinks.
Implementing the Maternal Postnatal Attachment Scale (MPAS) in universal services: Qualitative interviews with health visitors
Authors: Bird Philippa K , Hindson Zoe , Dunn Abigail , Cronin de Chavez Anna , Dickerson Josie , Howes Joanna , Bywater Tracey 
Published: January 2023

Background: A secure parent-infant relationship lays the foundations for children’s development, however there are currently no measurement tools recommended for clinical practice. We evaluated the clinical utility of a structured assessment of the parent-infant relationship (the Maternal Postnatal Attachment Scale, MPAS) in a deprived, multi-ethnic urban community in England. This paper answers the question: what are health visitors’ views on the parent-infant relationship, and experiences of piloting the MPAS? It explores the barriers and facilitators to implementation, and complements the paper on psychometric properties and representativeness reported in Dunn et al (2022). Methods: Semi-structured interviews were conducted with 11 health visitors and data were analysed using thematic analysis. Results: Health visitors saw identification and support of the parent-infant relationship as an important part of their role, and reported benefits of the MPAS, including opening conversation and identifying and reporting concerns. Challenges included timing and workload, the appropriateness of language, perceived intrusiveness and understanding of the questions, and the length of the tool. Suggestions for improvements to the tool were put forward. Conclusions: The experiences, benefits and challenges identified help to explain results in Dunn et al, and the wide-ranging challenges identified would hinder assessment of the parent-infant relationship in routine practice. Further work with health professionals and parents has been undertaken to co-produce an acceptable, feasible and reliable tool for clinical practice.
Out-of-pocket payments during childbirth in Kenya under the free maternity services: Perspectives of mothers, healthcare workers and county officials
Authors: Oyugi Boniface , Kendall Sally , Peckham Stephen , Barasa Edwine 
Published: January 2023

Background: This study seeks to determine the extent of women's out-of-pocket (OOP) payments for delivery under the free maternity policy (FMP). Methods: We conducted a convergent parallel mixed-methods study using quantitative and qualitative data collection. The study was set in three facilities (levels 3, 4, and 5) in Kiambu County, Kenya. The study involved exit interview (EI) surveys with mothers (n = 553) who utilised FMP delivery services and focus group discussions (FGDs) with mothers who returned for postnatal visits (6, 10, and 14 weeks). There were 21 in-depth interviews (IDIs) with county officials and healthcare workers (HCWs). Quantitative data were analysed using descriptive statistics, while qualitative data were audio-recorded, transcribed and analysed using thematic analysis. Results: Despite the FMP being free on paper, mothers incurred OOP payments in practice. The overall mean OOP payments incurred by mothers who underwent normal delivery was 9.50 USD (SD 8.20 USD), and caesarean section (CS) was 10.88 USD (SD 15.16 USD). The main cost drivers were transport, lack of adequate supply and medications, lack of policy clarity by health workers, failure to notify the NHIF office of available clients, and ultrasound scan services. While the OOP payments were not deemed catastrophic, some women perceived it as a barrier to care as they ended up using savings or selling their assets to meet the costs. There were no patient characteristics associated with OOP payments. Conclusions: OOP payments during childbirth in Kenya place a considerable economic burden on mothers and their households. There is need to promote awareness of the policy and provide a sustainable form of transport, especially during emergencies, through collaboration with partners. Prioritising the supply of required medication used in maternal services in the universal health care benefits package to which Kenyan citizens are entitled, or sustainably financing the FMP is crucial.
Revisiting Semidefinite Programming Approaches to Options Pricing: Complexity and Computational Perspectives
Authors: Henrion Didier , Kirschner Felix , De Klerk Etienne , Korda Milan , Lasserre Jean-Bernard , Magron Victor 
Published: January 2023

In this paper, we consider the problem of finding bounds on the prices of options depending on multiple assets without assuming any underlying model on the price dynamics but only the absence of arbitrage opportunities. We formulate this as a generalized moment problem and utilize the well-known moment-sum-of-squares hierarchy of Lasserre to obtain bounds on the range of the possible prices. A complementary approach (also from Lasserre) is employed for comparison. We present several numerical examples to demonstrate the viability of our approach. The framework we consider makes it possible to incorporate different kinds of observable data, such as moment information, as well as observable prices of options on the assets of interest. History: Accepted by Antonio Frangioni, area editor for Design & Analysis of Algorithms–Continuous. Funding: This work was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement [Grant 813211 (POEMA)]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplementary Information [ https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1220 ] or is available from the IJOC GitHub software repository ( https://github.com/INFORMSJoC ) at [ http://dx.doi.org/10.5281/zenodo.6602361 ].
Distribution of heavy metal (Pb, Cd and Hg) concentrations in sediment of Bone River, Gorontalo
Authors: Kadim Miftahul Khair , Yuli Endang Herawati , Arfiati Diana , Hertika Asus Maizar Suryanto , Kasim Faizal 
Published: January 2023

The concentration of three heavy metals Pb, Cd and Hg ware measured in Bone River, Gorontalo sediment. The heavy metal pollution on sediment in Bone River have not been explored longitudinally. The samples were taken in July 2021 at 8 stations. The trend of metals ware observed in sediment as PbCdHg. The level of studied metals Cd and Hg did not exceed the safe limit by ANZECC, OSQG LEL and CCME TEL meanwhile Pb was met the limit by by ANZECC. However, the investigated showed that fluctuations due to differences in the characteristics of each location. Contamination factor (CF) and geoaccumulation index (Igeo) demonstrated that the sediment samples were low contamination and lightly polluted. Contamination by heavy metals in the Bone River implies that the conditions are much frightening for the biota and residents around the river.
Low-loss and broadband cascaded SiN RGB coupler with dual-mode interference
Authors: Hu Xiao-Long , Jiang Jian-Kun , Liu Wen-Jie 
Published: January 2023

We design and demonstrate a cascaded SiN-based RGB coupler with dual-mode interference (DMI) for a micro laser scanning image projector. The DMI configuration in SiN-based waveguides mitigates the adverse effects of self-image point deviation caused by wavelength dispersion, achieving decreased device length and high transmission efficiency. The underlying mechanisms are discussed based on coupled-mode theory and 3D finite difference time domain simulation. A small footprint of

3

µ

m

×
70

µ

m

is achieved for the RGB coupler device without input/output circuits, and the insertion losses are less than 0.56 dB at RGB wavelengths. There are two orders of magnitude reduction in device length as compared with the conventional

S
i

O

2

-based RGB coupler, which greatly promotes the miniaturization of the couplers and displays integration advantages with a laser diode and waveguide photodetector. In addition, the 3 dB bandwidth is over 50 nm for the coupler, and it demonstrates good fabrication tolerance. This design can further be integrated into visible light communication systems and applied to visible light integrated photonics.
Detection of biomarkers using terahertz metasurface sensors and machine learning
Authors: Lin Shangjun , Chen Jie , Liu Wentao , Peng Zhenyun , Chen Zhencheng , Hu Fangrong 
Published: January 2023

To achieve classification and concentration detection of cancer biomarkers, we propose a method that combines terahertz (THz) spectroscopy, metasurface sensors, and machine learning. A metasurface sensor suitable for biomarker detection was designed and fabricated with five resonance frequencies in the range of 0.3–0.9 THz. We collected biomarkers of five types and nine concentrations at 100 sets of time-domain spectra per concentration. The spectrum is processed by noise reduction and fast Fourier transform to obtain the frequency-domain spectrum. Five machine learning algorithms are used to analyze time- and frequency-domain spectra and ascertain which algorithm is more suitable for the classification of the biomarker THz spectrum. Experimental results show that random forest can better distinguish five biomarkers with an accuracy of 0.984 for the time-domain spectrum. For the frequency-domain spectrum, the support vector machine performs better, with an accuracy of 0.989. For biomarkers at different concentrations, we used linear regression to fit the relationship between biomarker concentration and frequency shift. Experimental results show that machine learning can distinguish different biomarker species and their concentrations by the THz spectrum. This work provides an idea and data processing method for the application of THz technology in biomedical detection.
Refractive index sensors based on cascaded multimode interference hetero-core optical fibers
Authors: de Oliveira Hebio J. B. , da Silva Allamys A. D. , Peixoto e Silva Marianne S. , Alves Henrique P. , do Nascimento Jehan F. , Martins-Filho Joaquim F. 
Published: January 2023

In this work, we demonstrate refractive index (RI) sensors based on the cascade of hetero-core structures using multimode and no-core optical fibers in sequence. The sensor device is engineered to have resonances at different wavelengths using different sensing region lengths. The device fabrication involves simple fiber cleaving and fusion splicing. For the experiments, the two sensor regions are exposed to liquids with different RIs. For the hetero-core fiber insertion length of 45 mm, the transmission valley is centered at 1082.5 nm with 15.1 nm full width at half-maximum (FWHM) for an external medium RI of 1.3370. Additionally, it shifts 4.1 nm towards longer wavelengths as the RI of the external medium increases to 1.3840. For the 30 mm long hetero-core structure, the valley is centered at 1599.7 nm with 23.3 nm FWHM for an external medium RI of 1.3370, which shifts 7.4 nm as the RI increases to 1.3840. The sensor sensitivities are up to

−

476

d
B

/

r
e
f
r
a
c
t
i
v
e

index unit (RIU) and 270 nm/RIU. The resolution of the devices is estimated to be

2
×
10

−
5

R
I
U

.
Safety of the bag-in-the-lens implantation regarding the development of clinically significant pseudophakic cystoid macular edema: A retrospective case series study
Authors: Scheers Dorothée , Rens Jasmien , Van Os Luc , Ní Dhubhghaill Sorcha , De Groot Veva , Kiekens Stefan , Van Looveren Jan , Wouters Kristien , Tassignon Marie-José 
Published: January 2023

Purpose
To determine the incidence of clinically significant pseudophakic cystoid macular edema (CSPME) after phacoemulsification using the ‘bag-in-the-lens’ lens (BIL) implantation technique and to examine the influence of associated risk factors for clinically significant pseudophakic macular edema (CSPME), both ocular and systemic.

Methods
This retrospective study included 2419 first-operated eyes of 2419 adults who underwent phacoemulsification cataract surgery using the BIL implantation technique between January 2013 and December 2018 in the Antwerp University Hospital, Belgium. The significance of several risk factors (age, gender, previous history, intra- and postoperative complications) was examined by extraction of electronic medical files.

Results
The 3-month incidence of CSPME in the subgroup without risk factors was 0.00% (95% CI: 0.00 –NA). The 3-month incidence of CSPME in the subgroup with risk factors was 0.57% (95% CI 0.22–1.29%).
The 3-month incidence of CSPME in the total population of 2419 patients was 0.29% (95% CI: 0.11–0.65%). The risk factors most significantly associated with CSPME included renal insufficiency (hazard ration [HR]: 5.42; 95% CI: 1.69–17.44; P = .014), exudative age-related macular degeneration (HR: 74.50, 95% CI: 25.75–215.6; P < .001) and retinal vein occlusion (HR: 22.48, 95% CI: 4.55–111.02; P = .005).

Conclusions
In the absence of risk factors, the incidence of CSPME was zero. We can conclude that Primary Posterior Continuous Curvilinear Capsulorhexis (PPCCC) does not increase the risk for CSPME.
Non-inferiority of the BIL implantation regarding the development of CSPME, relative to the traditional ‘lens-in-the-bag’ (LIB) implantation, confirms that BIL is a safe surgical technique. This study also illustrates a previously undescribed risk factor for developing CSPME, namely renal insufficiency.