bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Analysis of Bubble Behavior and Critical Heat Flux During Pool Boiling on Vertical Circular Tubes
Authors: Pattanayak Bikash , Kothadia Hardik B. 
Published: July 2023

Abstract
The heat transfer during pool boiling incorporates a higher rate of heat dissipation capability at low-temperature differences. This technique is widely used in the nuclear industry for thermal management. In this study, the effect of tube diameter and length on critical heat flux (CHat atmospheric conditions in saturated water during pool boiling) is analyzed. The tubes of SS 304 are kept in the vertical orientation. The diameter of the tubes ranges from 1.2 mm to 9 mm. The experiments are performed with tubes having lengths varying from 50 mm to 1000 mm. It has been noted that tubes of smaller diameter show a greater magnitude of critical heat flux (CHF) for the given length. Compared to other tubes, the magnitude of CHF for a 1.2 mm diameter is higher. For a given diameter, a longer tube is found to have lower CHF than the ones having lesser length. The variation in the CHF magnitude is negligible for tubes with a diameter of more than 2.5 mm beyond a length of 200 mm. The location of occurrence of CHF is near the bottom end of the vertical tube. The study illustrates the behavior of bubble nucleation for various tube dimensions and heat fluxes. The inception and detachment of bubbles for different tubes are analyzed. The pool boiling regime is categorized and studied basing the behavior of the incepted and departed bubble while maintaining uniform heat flux. A mathematical relation that empirically accounts for the effect of tube dimensions , i.e., length and diameter on pool boiling CHF is proposed. The experimental CHF data obtained during pool boiling are tabulated toward contributing to the CHF databank.
Excitation of a Separated Flow by a Series of Protuberances Near the Leading Edge of a Model Aerofoil
Authors: Singh Pradeep , Sarkar S. 
Published: July 2023

Abstract
This article documents the manifestation of a shear layer under the excitation of a series of hemispherical protuberances near the leading edge of a constant-thickness airfoil. The experiments are performed at a Reynolds number of 1.6 × 105 based on the chord length and inlet velocity, where freestream turbulence is 1.2%. The hotwire and particle image velocimetry data are analyzed to appreciate the flow feature, illustrating the growth of perturbations, vortex dynamics, intermittency, and spectral response. A laminar separation bubble (LSB) appears near the leading edge for a smooth surface, and the shear layer is inviscidly unstable. The evolution of the shear layer significantly changes with a series of protuberances. The breakdown of the shear layer occurs almost immediately, triggering local turbulence resulting in a considerable reduction of the bubble length. However, a separation bubble of varying spanwise lengths is formed in this case. Although the power spectra of velocity fluctuations reveal the selective amplification of frequencies even with protuberances, the immediate augmentation of turbulence followed by faster decay suggests the transient growth of turbulence. The study has documented insight into features of a separation bubble subjected to leading-edge perturbations and might influence future studies on separation control over an airfoil.
Preparing to Land: Hamstring Preactivation Is Higher in Females and Is Inhibited by Fatigue
Authors: Phillips David Alan , Buckalew Bridgette Rae , Keough Bridget , Alencewicz Jacklyn Stephanie 
Published: July 2023

The hamstring plays an important role in reducing loads born by the anterior cruciate ligament. As anterior cruciate ligament injuries occur rapidly after ground contact, how the hamstring is activated prior to landing can influence injury risk. The purpose was to determine sex-related differences in hamstring activation immediately before landing and the effect of fatigue on “preactivation.” Twenty-four participants (13 males and 11 females, age = 24.3 [6.5] y, mass = 72.2 [19.3] kg, height = 169 [9.7] cm) participated in this study. Participants completed a drop-vertical jump protocol before and after a lower body fatigue protocol. Hamstring electromyography (EMG) amplitude at 5 periods prior to landing, peak vertical ground reactions forces (in newtons/body weight), rate of loading (in body weight/second), and landing error scoring system were measured. Females had higher EMG amplitude before and after fatigue (P < .024), with decreased EMG amplitude for both sexes after fatigue (P = .025). There was no change on vertical ground reaction force, rate of loading, or landing error scoring system. Males and females demonstrated similar landing performance before and after fatigue but have different hamstring neuromuscular coordination strategies. The acute reduction in hamstring EMG amplitude following fatigue may increase loading on the anterior cruciate ligament.
Fault-related sanctuaries of Mycenae (Greece): The Shaft Grave Circle A
Authors: Piccardi Luigi 
Published: July 2023

Mycenae, one of the most important cities and sacred sites of antiquity in Greece, was built on a tectonic horst uplifted by active normal faults, and both faults show geologic evidence of recent coseismic slip. The Lion Gate fault, affecting the west slope of Mycenae, is described here through geological and archaeoseismological investigation. The tectonic offset since the Pliocene−Pleistocene sequence is 13−14 m. A 4−5-m-high scarp of the major splay of this fault, well preserved inside the Shaft Grave Circle A, exhibits tectonic geomorphological aspects typical of recent surface faulting.
Mycenae experienced two earthquakes in ∼60 yr during its climax, one around 1250 B.C. and the other around 1190 B.C. Seismic damage at Shaft Grave Circle A was found to have occurred on more than one occasion. One event occurred with the earthquake of 1190 B.C., or more likely with a much later one, which cut the circular parapet. Heavy damages were also registered with the earthquake of 1250 B.C. An episode of surface faulting appears to have occurred shortly before the early graves were created in Shaft Grave Circle A (late seventeenth century B.C., Middle/Late Helladic period).
The integration of available data suggests that the cults at Mycenae, particularly at Shaft Grave Circle A, deliberately chose specific sites or traits of the seismic fault as the central hub of their main sanctuaries. This occurrence was the result of a deliberate choice dictated by the fact that those sites along the fault trace were considered to be sacred and believed to be gateways to Hades.
The global health and care worker compact: evidence base and policy considerations
Authors: Friedman Eric A , Bickford Robert , Bjork Charles , Campbell James , Cometto Giorgio , Finch Alexandra , Kane Catherine , Wetter Sarah , Gostin Lawrence 
Published: July 2023

BackgroundDuring the COVID-19 pandemic, and recognising the sacrifice of health and care workers alongside discrimination, violence, poor working conditions and other violations of their rights, health and safety, in 2021 the World Health Assembly requested WHO to develop a global health and care worker compact, building on existing normative documentation, to provide guidance to ‘protect health and care workers and safeguard their rights’.MethodsA review of existing international law and other normative documents was conducted. We manually searched five main sets of international instruments: (1) International Labour Organization conventions and recommendations; (2) WHO documents; (3) United Nations (UN) human rights treaties and related documents; (4) UN Security Council and General Assembly resolutions and (5) the Geneva Conventions and Additional Protocols. We included only legal or other normative documents with a global or regional focus directly addressing or relevant to health and care workers or workers overall.ResultsMore than 70 documents met our search criteria. Collectively, they fell into four domains, within which we identified 10 distinct areas: (1) preventing harm, encompassing (A) occupational hazards, (B) violence and harassment and (C) attacks in situations of fragility, conflict and violence; (2) inclusivity, encompassing (A) non-discrimination and equality; (3) providing support, encompassing (A) fair and equitable remuneration, (B) social protection and (C) enabling work environments and (4) safeguarding rights, encompassing (A) freedom of association and collective bargaining and (B) whistle-blower protections and freedom from retaliation.DiscussionA robust legal and policy framework exists for supporting health and care workers and safeguarding their rights. Specific human rights, the right to health overall, and other binding and non-binding legal documents provide firm grounding for the compact.However, these existing commitments are not being fully met. Implementing the compact will require more effective governance mechanisms and new policies, in partnership with health and care workers themselves.
Substantial increase in stillbirth rate during the COVID-19 pandemic: results from a population-based study in the Indian state of Bihar
Authors: Dandona Rakhi , Kumar G Anil , Akbar Md , Dora S Siva Prasad , Dandona Lalit 
Published: July 2023

IntroductionWe report on the stillbirth rate (SBR) and associated risk factors for births during the COVID-19 pandemic, and change in SBR between prepandemic (2016) and pandemic periods in the Indian state of Bihar.MethodsBirths between July 2020 and June 2021 (91.5% participation) representative of Bihar were listed. Stillbirth was defined as fetal death with gestation period of ≥7 months where the fetus did not show any sign of life. Detailed interviews were conducted for all stillbirths and neonatal deaths, and for 25% random sample of surviving live births. We estimated overall SBR, and during COVID-19 peak and non-peak periods per 1000 births. Multiple logistic regression models were run to assess risk factors for stillbirth. The change in SBR for Bihar from 2016 to 2020–2021 was estimated.ResultsWe identified 582 stillbirths in 30 412 births with an estimated SBR of 19.1 per 1000 births (95% CI 17.7 to 20.7); SBR was significantly higher in private facility (38.4; 95% CI 34.3 to 43.0) than in public facility (8.6; 95% CI 7.3 to 10.1) births, and for COVID-19 peak (21.2; 95% CI 19.2 to 23.4) than non-peak period (16.3; 95% CI 14.2 to 18.6) births. Pregnancies with the last pregnancy trimester during the COVID-19 peak period had 40.4% (95% CI 10.3% to 70.4%) higher SBR than those who did not. Risk factor associations for stillbirths were similar between the COVID-19 peak and non-peak periods, with gestation age of <8 months with the highest odds of stillbirth followed by referred deliveries and deliveries in private health facilities. A statistically significant increase of 24.3% and 68.9% in overall SBR and intrapartum SBR was seen between 2016 and 2020–2021, respectively.ConclusionsThis study documented an increase in SBR during the COVID-19 pandemic as compared with the prepandemic period, and the varied SBR based on the intensity of the COVID-19 pandemic and by the place of delivery.
Exploring participant attrition in a longitudinal follow-up of older adults: the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort
Authors: Okpara Chinenye , Adachi Jonathan , Papaioannou Alexandra , Ioannidis George , Thabane Lehana 
Published: July 2023

ObjectiveWe explored the magnitude of attrition, its pattern and risk factors for different forms of attrition in the cohort from the Global Longitudinal Study of Osteoporosis in Women.DesignProspective cohort study.SettingParticipants were recruited from physician practices in Hamilton, Ontario.ParticipantsPostmenopausal women aged ≥55 years who had consulted their primary care physician within the last 2 years.Outcome measuresTime to all-cause, non-death, death, preventable and non-preventable attrition.ResultsAll 3985 women enrolled in the study were included in the analyses. The mean age of the cohort was 69.4 (SD: 8.9) years. At the end of the follow-up, 30.2% (1206/3985) of the study participants had either died or were lost to follow-up. The pattern of attrition was monotone with most participants failing to return after a missed survey. The different types of attrition examined shared common risk factors including age, smoking and being frail but differed on factors such as educational level, race, hospitalisation, quality of life and being prefrail.ConclusionAttrition in this ageing cohort was selective to some participant characteristics. Minimising potential bias associated with such non-random attrition would require targeted measures to achieve maximum possible follow-rates among the high-risk groups identified and dealing with specific reasons for attrition in the study design and analysis.
PakSurg 1: determining the epidemiology and risk factors of surgical site infections in Pakistan—a multicentre, prospective cohort study
Authors:   PakSurg Collaborative
Published: July 2023

IntroductionSurgical site infections (SSIs) are among the the most common postoperative complications, despite being highly preventable. Multiple studies have explored the incidence and risk factors of SSIs globally. However, nationally representative data capable of informing evidence-based guidelines remain limited in Pakistan. Hence, the aim of this study is to identify the incidence and risk factors of developing SSIs following surgery and to explore existing SSI prevention practices in Pakistan.Methods and analysisThis study is a multicentre, prospective cohort study across various sites in Pakistan. All consecutive adult patients undergoing inpatient elective surgery in a 1 month patient recruitment window from one or more of the nine eligible subspecialties will be included in the study. Patients with preoperative infections, emergency surgeries or intraoperative mortality are to be excluded. The following surgical subspecialties are included: breast surgery, cardiac surgery, colorectal surgery, cranial surgery, general surgery, obstetrics and gynaecology, orthopaedics surgery, spine surgery and vascular surgery. Each mini-team of up to three collaborators can select one of the nine subspecialties and a 1 month patient recruitment window from 20 September 2022 to 31 March 2023. Multiple mini-teams from the same sites can recruit patients across the same subspecialty in distinct patient recruitment windows. Additionally, multiple mini-teams from the same sites can recruit patients across different subspecialties in the same or distinct patient recruitment windows. The primary outcome is 30 day SSIs. Secondary outcomes include 30 day antibiotic-resistant SSIs, organ-space infections, other healthcare associated infections, reinterventions and all-cause mortality.Ethics and disseminationApproval was received by the Aga Khan University (AKU) Ethics Review Committee (ERC) and the National Bioethics Committee (NBC) Pakistan. The results from this study will be disseminated by the steering committee in journal publications, conference presentations and on other academic platforms. Evidence-based guidelines that result from these data will be disseminated to all surgical care providers in Pakistan through national networks.
Mathematical modelling of micropolar thermoelastic problem with nonlocal and hyperbolic two-temperature based on Moore–Gibson–Thompson heat equation
Authors: Kumar Rajneesh , Kaushal Sachin , Kochar Arun 
Published: July 2023

The aim of this article is to study a problem of thermomechanical deformation in a homogeneous, isotropic, micropolar thermoelastic half-space based on the Moore–Gibson–Thompson heat equation under the influence of nonlocal and hyperbolic two-temperature (HTT) parameters. The problem is formulated for the considered model by reducing the governing equations into 2D and then converting to dimensionless form. Laplace transform and Fourier transform techniques are employed to obtain the system of differential equations. In the transformed domain, the physical quantities like displacement components, stresses, thermodynamic temperature, and conductive temperature are calculated under the specific types of normal force and thermal source at the boundary surface. A numerical inversion technique is used to recuperate the equations in the physical domain to exhibit the influence of nonlocal and HTT in the form of graphs. Particular cases of interest are also discussed in the present problem. The present study finds applications in a wide range of problems in engineering and sciences, control theory, vibration mechanics, and continuum mechanics.
A proof of concept for matchete: an automated tool for matching effective theories
Authors: Fuentes-Martín Javier , König Matthias , Pagès Julie , Thomsen Anders Eller , Wilsch Felix 
Published: July 2023

AbstractStudying the impact of new-physics models on low-energy observables necessitates matching to effective field theories at the relevant mass thresholds. We introduce the first public version of , a computer tool for matching weakly-coupled models at one-loop order. It uses functional methods to directly compute all matching contributions in a manifestly gauge-covariant manner, while simplification methods eliminate redundant operators from the output. We sketch the workings of the program and provide examples of how to match simple Standard Model extensions. The package, documentation, and example notebooks are publicly available at https://gitlab.com/matchete/matchete.
Baseline Mutations and ctDNA Dynamics as Prognostic and Predictive Factors in ER-Positive/HER2-Negative Metastatic Breast Cancer Patients
Authors: Pascual Javier , Gil-Gil Miguel , Proszek Paula , Zielinski Christoph , Reay Alistair , Ruiz-Borrego Manuel , Cutts Rosalind , Ciruelos Gil Eva M. , Feber Andrew , Muñoz-Mateu Montserrat , Swift Claire , Bermejo Begoña , Herranz Jesus , Margeli Vila Mireia , Antón Antonio , Kahan Zsuzsanna , Csöszi Tibor , Liu Yuan , Fernandez-Garcia Daniel , Garcia-Murillas Isaac , Hubank Michael , Turner Nicholas C. , Martín Miguel 
Published: July 2023

Abstract

Purpose:
Prognostic and predictive biomarkers to cyclin-dependent kinases 4 and 6 inhibitors are lacking. Circulating tumor DNA (ctDNA) can be used to profile these patients and dynamic changes in ctDNA could be an early predictor of treatment efficacy. Here, we conducted plasma ctDNA profiling in patients from the PEARL trial comparing palbociclib+fulvestrant versus capecitabine to investigate associations between baseline genomic landscape and on-treatment ctDNA dynamics with treatment efficacy.

Experimental Design:
Correlative blood samples were collected at baseline [cycle 1-day 1 (C1D1)] and prior to treatment [cycle 1-day 15 (C1D15)]. Plasma ctDNA was sequenced with a custom error-corrected capture panel, with both univariate and multivariate Cox models used for treatment efficacy associations. A prespecified methodology measuring ctDNA changes in clonal mutations between C1D1 and C1D15 was used for the on-treatment ctDNA dynamic model.

Results:
201 patients were profiled at baseline, with ctDNA detection associated with worse progression-free survival (PFS)/overall survival (OS). Detectable TP53 mutation showed worse PFS and OS in both treatment arms, even after restricting population to baseline ctDNA detection. ESR1 mutations were associated with worse OS overall, which was lost when restricting population to baseline ctDNA detection. PIK3CA mutations confer worse OS only to patients on the palbociclib+fulvestrant treatment arm. ctDNA dynamics analysis (n = 120) showed higher ctDNA suppression in the capecitabine arm. Patients without ctDNA suppression showed worse PFS in both treatment arms.

Conclusions:
We show impaired survival irrespective of endocrine or chemotherapy-based treatments for patients with hormone receptor–positive/HER2-negative metastatic breast cancer harboring plasma TP53 mutations. Early ctDNA suppression may provide treatment efficacy predictions. Further validation to fully demonstrate clinical utility of ctDNA dynamics is warranted.
Colorectal Cancer Organoid–Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses
Authors: Farin Henner F. , Mosa Mohammed H. , Ndreshkjana Benardina , Grebbin Britta M. , Ritter Birgit , Menche Constantin , Kennel Kilian B. , Ziegler Paul K. , Szabó Lili , Bollrath Julia , Rieder Dietmar , Michels Birgitta E. , Kress Alena , Bozlar Müge , Darvishi Tahmineh , Stier Sara , Kur Ivan-Maximilano , Bankov Katrin , Kesselring Rebecca , Fichtner-Feigl Stefan , Brüne Bernhard , Goetze Thorsten O. , Al-Batran Salah-Eddin , Brandts Christian H. , Bechstein Wolf O. , Wild Peter J. , Weigert Andreas , Müller Susanne , Knapp Stefan , Trajanoski Zlatko , Greten Florian R. 
Published: July 2023

Abstract

In colorectal cancers, the tumor microenvironment plays a key role in prognosis and therapy efficacy. Patient-derived tumor organoids (PDTO) show enormous potential for preclinical testing; however, cultured tumor cells lose important characteristics, including the consensus molecular subtypes (CMS). To better reflect the cellular heterogeneity, we established the colorectal cancer organoid–stroma biobank of matched PDTOs and cancer-associated fibroblasts (CAF) from 30 patients. Context-specific phenotyping showed that xenotransplantation or coculture with CAFs improves the transcriptomic fidelity and instructs subtype-specific stromal gene expression. Furthermore, functional profiling in coculture exposed CMS4-specific therapeutic resistance to gefitinib and SN-38 and prognostic expression signatures. Chemogenomic library screening identified patient- and therapy-dependent mechanisms of stromal resistance including MET as a common target. Our results demonstrate that colorectal cancer phenotypes are encrypted in the cancer epithelium in a plastic fashion that strongly depends on the context. Consequently, CAFs are essential for a faithful representation of molecular subtypes and therapy responses ex vivo.

Significance:
Systematic characterization of the organoid–stroma biobank provides a resource for context dependency in colorectal cancer. We demonstrate a colorectal cancer subtype memory of PDTOs that is independent of specific driver mutations. Our data underscore the importance of functional profiling in cocultures for improved preclinical testing and identification of stromal resistance mechanisms.
This article is featured in Selected Articles from This Issue, p. 2109
Power quality enhancement by using Z-DVR based series voltage compensation with black widow optimization technique
Authors: Kumar Ch. Srivardhan , Livinsa Z. Mary 
Published: July 2023

In distribution system, voltage quality issues are the most concerning disturbances influencing the power quality (PQ). As a result, to alleviate this PQ concerns such as sag, swell, fluctuation, interruption, and harmonics on the sensitive load, the series voltage compensator dynamic voltage restorer (DVR) is utilized. Furthermore, a Z-source inverter (ZSI) based DVR is proposed in this paper to improve the power system's voltage restoration properties. To compensate the voltage concerns which is occurs in passive and transmission components, the 3-φ Z-DVR inverter with proportional integral derivative (PID) controller tuned by black widow optimization (BWO). By short circuiting the legs of inverter in the ZSI, prepare the possibility of buck and boost in voltage and utilize the LC impedance grid which incorporated power source to inverter circuit. In addition, to obtain the injecting voltage, PID control scheme for ZSI based DVR is proposed in this paper. The proposed modelling and simulation of DVR is implemented in MATLAB/Simulink tool and the outcomes are analyzed. Furthermore, reduction in voltage concerns, and total harmonics distribution (THD) with BWO tuned PID controller is superior which is 1.01% when compared with existing methods such as Harris Hawks optimization (HHO) based PID, genetic algorithm (GA) based PID controller.