bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial characteristics and security of podiatry work in Victoria: the PAIGE cross sectional study of Australian podiatrists
Authors: Couch Anna Grace , Haines Terry , O'Sullivan Belinda , Menz Hylton B , Williams Cylie M 
Published: June 2023

Abstract
Background
Podiatrists’ earnings have an important influence on workforce dynamics. This includes the profession’s ability to retain workers so the populations healthcare needs can be met. This study aimed to describe factors relating to Victorian podiatrists’ financial characteristics and security.
Methods
This was a cross sectional study using data from Victorian podiatrists who participated in Wave 1 of the Podiatrists in Australia: Investigating Graduate Employment (PAIGE) survey. Demographic and financial characteristics were described. The outcome measure, financial security, was collected through a self-reported belief based on current financial situation and prospects, respondents perception of having enough income to live on when they retire. Univariate logistic regression was used to determine associations with rural or metropolitan practice locations. Multiple ordered logistic regression was performed to explore associations between factors relating to financial security and retirement prospects.
Results
There were 286 Victorian podiatrist (18% of n = 1,585 Victorian podiatrists) respond. Of these, 206 (72% of n = 286) identified as female, 169 (59% of 286) worked in the private sector and the mean (SD) age was 33.4 (9.5) years. The mean (SD) annual gross income was $79,194 ($45,651) AUD, and 243 (87% of 279) made regular superannuation contributions. Multiple ordered logistic regression analyses identified factors associated with podiatrists’ perception of having adequate retirement income. These included being an owner/partner of their main workplace (adj OR = 2.70, 95% CI = 1.49–4.76), growing up in a rural location (adj OR = 2.27, 95% CI = 1.38–3.70), perceiving a moderate overall health rating (adj OR = 2.03 95% CI = 1.51–2.75), not having financial debt related to education and training (adj OR = 2.02, 95% CI = 1.24–3.32) and regular contributions to a superannuation scheme (adj OR = 4.76, 95% CI = 2.27-10.00).
Conclusion
This is the first known study to explore podiatrists’ earnings and perceptions regarding financial security for retirement. Findings suggest modifiable ways to improve financial security of podiatrists including support and education about personal and business finances including debt management and understanding the importance of contributions to superannuation when self-employed, or skills and supports for podiatrists to run their own businesses. This research is exploratory and is relevant for understanding the impact that income and financial security have on workforce capacity.
Metabolomics and machine learning technique reveals that germination enhances the multi-nutritional properties of pigmented rice
Authors: Fernie Alisdair 
Published: June 2023

Abstract
Enhancing the dietary properties of rice is crucial to contribute to alleviating hidden hunger and non-communicable diseases in rice-consuming countries. Germination is a bioprocessing approach to increase the nutritional properties of seeds. However, there is scarce information on how germination impacts the overall nutritional profile of pigmented rice sprouts. Herein, we demonstrated that germination could increase certain dietary compounds, such as phenolics, GABA, and micronutrients, and induce new flavonoid glycosides. Minerals such as Ca, Na, Fe, Zn, and vitamins such as riboflavin and biotin increased upon germination. In addition, this process decreased toxic elements like aluminum. This process allowed for a decrease in bound phenolics leading to an increase in free phenolics. Metabolomic analysis revealed the preferential accumulation of flavonoid compounds in the germination process. Genome-wide association studies of the altered metabolites revealed the activation of specific genes responsible for increasing certain flavonoid compounds. Notably, the activation of the CHS1 gene boosted the naringenin and the compounds along this pathway. Likewise, the UGT gene is responsible for the formation of flavonoid glycosides derived from kaempferol, caffeic acid, ferulic acid, and quercetin. Haplotype analyses showed a significant difference (P < 0.05) between alleles associated with this genetic region. Genetic markers associated with these flavonoids were incorporated into the random forest model, improving the accuracy from 89.7% to 97.7%. Consistent with this feature, the improved model has a faster prediction speed in a shorter training time. The elite cultivars can breed rice with multi-nutritional properties, and the model could screen rice with several dietary benefits.
The influence of organic components in sludge on selective non-catalytic reduction denitrification
Authors: Wang Yali , Zong Xiaotong , Song Yihui , Cui Suping 
Published: June 2023

Abstract
Collaborative disposal of sludge has been applied extensively in cement industry kilns，but the influence of organic components in sludge on the SNCR denitrification is still in highly demanding. This paper focuses the influence of ethanol, n-octane, benzene and acetone on the SNCR denitrification, and the influence of ethanol are analyzed on SNCR denitrification under different flue gas condition. The result showed that ·H and ·OH as active groups are produced during the combustion of organic components, promoting the generation of ·NH2 from NH3, and therein the lower reaction temperature of SNCR. When the temperature of SNCR reaction is at 750~800℃, the denitrification rate of four organic components is: ethanol > benzene > n-octane > acetone. The optimum denitrification rate on SNCR can reach as high as 90.377% when the reaction condition is: the NH3/NO is 1, the ethanol concentration is 1000ppm, O2 concentration is 2% and temperature is 750℃. In this paper, the influence of organic components in sludge on SNCR denitrification will be analyzed, which provides a theoretical basis for the selection of sludge dosing method for cement kiln collaborative disposal.
ENCOURAGEing Start: A Quasi-experimental Trial on Pre-Op Physical Activity Intervention for Bariatric Surgery Candidates
Authors: Edye-Mazowita Alex , He Wenjing , Duhamel Todd A. , Hardy Krista , Vergis Ashley 
Published: June 2023

Abstract

Introduction
The American Society for Metabolic and Bariatric Surgery recommends pre- and post-operative physical activity (PA). However, there are no effective standardized PA programs incorporating a behavioral change approach for bariatric surgery patients. A novel pre-operative PA intervention ENCOURAGEing Start was developed and piloted to assist patients in reducing barriers to PA and encouraging positive PA habits.
Methods
This single arm pilot study recruited patients (n=27, BMI = 47.1 ± 6.2) from the Victoria General Hospital’s Centre for Metabolic and Bariatric Surgery in Winnipeg, Manitoba between September 2017 and May 2018. A time-series quasi-experimental design was used. The 16-week intervention took place at the University of Manitoba’s Active Living Centre. The primary outcome was a six-minute walk test (6MW), a measure of functional ability and predictive of post-surgical weight loss and maintenance. Secondary outcomes included fitness, cardiovascular disease risk and mental health. Outcomes were evaluated at baseline, 8 weeks, and 16 weeks.
Results
Ten patients completed the intervention. Clinically significant (p≤0.05) differences in the 6MW (457.21 vs 497.58 m, p=0.002), indirect 1RM leg press (283.72 vs 331.60 lb, p<0.001), sit-to-stand (12.78 vs 14.82, p<0.01), and quality of life (181.89 vs 195.96, p=0.028) were identified for completers.
Conclusions
The ENCOURAGEing Start intervention enhanced markers linked to long-term post-surgery outcomes, including a 10.7% increase in 6MW. This feasible program showed similar effect size to more resource intensive interventions, including those in Canada. A larger study with a minimum of 55 participants should be undertaken to assess the sustainability of these effects.
Microsurgical Training Curriculum in a gynecological breast cancer center – a benefit for patients and surgeons?
Authors: Schmidt Georg Philipp , Mayo Theresa , Paepke Stefan , Kiechle Marion , Müller Daniel 
Published: June 2023

Abstract
Purpose
Autologous breast reconstruction improves patient satisfaction and quality of life after mastectomy. In Germany, free flap surgery and implant-based reconstruction is usually separate between reconstructive surgery and gynaecology. Cooperation between the specialist disciplines and implementation of microsurgery into breast surgeon training could enhance surgical treatment for breast cancer patients.
Methods
At the breast cancer center at Klinikum rechts der Isar, TU Munich, a three-stage training program for autologous breast reconstruction and microsurgery for gynecological breast surgeons was developed. Between 2019 and 2022 74 women received autologous free flap breast reconstruction by a consistent team consisting of a gynaecological surgeon in training and an expert microsurgeon. Peri- and postoperative data were collected to analyse the feasibility and safety of a microsurgical training in gynaecology.
Results
Within the training, operative steps of free autologous breast reconstruction were increasingly taken over by the gynaecological surgeon in training. The analysis showed a decrease in operating times with consistently low complication rates during the training.
Conclusion
This study demonstrated that a training in free autologous breast reconstruction for gynaecological surgeons is safely feasible through close cooperation between gynaecological and reconstructive surgery.
The Importance of Facilitating Goal-Concordant Care (GCC) in a Pandemic: The MD Anderson Experience with hospitalized COVID-19 positive patients
Authors: Muthu Mayoora , Dalal Shalini , George Marina , Clavijo Cesar Simbaqueba , Lenz Caitlin , Nortje Nico 
Published: June 2023

Abstract
Purpose Provider-patient communication (PPC) about goals of care (GOC) facilitates goal-concordant care (GCC) delivery. Hospital resource limitations imposed during the pandemic made it vital to deliver GCC to a patient cohort with COVID-19 and cancer. Our aim was to understand the population and adoption of GOC-PPC along with structured documentation in the form of an Advance Care Planning (ACP) note.Methods A multidisciplinary GOC task force developed processes for ease of conducting GOC-PPC and implemented structured documentation. Data were obtained from multiple electronic medical record elements, with each source identified, data integrated and analyzed. We looked at PPC and ACP documentation pre and post implementation alongside demographics, length of stay (LOS), 30-day readmission rate and mortality.Results 494 unique patients were identified, 52% male, 63% Caucasian, 28% Hispanic, 16% African American and 3% Asian. Active cancer was identified in 81% patients, of which 64% were solid tumors and 36% hematologic malignancies. LOS was 9 days with a 30-day readmission rate of 15% and inpatient mortality of 14%. Inpatient ACP note documentation was significantly higher post-implementation as compared to pre-implementation (90% vs 8%, P < 0.05). We saw sustained ACP documentation throughout the pandemic suggesting effective processes.Conclusions The implementation of institutional structured processes for GOC-PPC resulted in rapid sustainable adoption of ACP documentation for COVID-19 positive cancer patients. This was highly beneficial for this population during the pandemic, as it demonstrated the role of agile processes in care delivery models, which will be beneficial in the future when rapid implementation is needed.
Surgical Outcomes of Percutaneous Endoscopic Lumbar Discectomy in Obese Adolescents with Lumbar Disc Herniation
Authors: Qu Lianjun , Wang Yongli , Wang Fei , Zhang Songou 
Published: June 2023

Abstract
In recent years, with improved living standards, adolescent obesity has been widely studied. The lumbar disc herniation (LDH) incidence in obese adolescents is increasing yearly. No clinical studies have reported the use of percutaneous endoscopic lumbar discectomy (PELD) in obese adolescent lumbar disc herniation (ALDH) patients. This study evaluated the preliminary surgical outcomes of PELD treatment of obese ALDH patients. Fifty-one ALDH patients underwent single-level PELD surgery between January 2014 and January 2020. Patients were divided into an obese group and a normal group. Patient characteristics and surgical variables were compared between the two groups. The VAS, ODI, and SF-36 scales were used to evaluate the preoperative and postoperative clinical efficacy. In this study, 19 patients were included in the obese group, and 28 were included in the normal group. There was no significant difference in age, sex, duration of low back pain, duration of leg pain, or operative level between the obese and normal groups preoperatively. The obese group had a longer operative time (OT) (101.9 ± 9.0 min vs. 84.3 ± 11.0 min, P < 0.001) and greater fluoroscopy times (41.0 ± 5.8 vs. 31.6 ± 7.0, P < 0.001) and a later time of ambulation (29.9 ± 4.0 vs. 25.0 ± 2.9, p < 0.001) than the normal group. The groups did not significantly differ in complications. The VAS score for back and leg pain and the ODI and SF-36 scores for functional status improved significantly postoperatively. The PELD procedure is a safe and feasible method for treating LDH in obese adolescents. Obese ALDH requires a longer OT, a larger fluoroscopy dose and a later timepoint for getting out of bed than normal ALDH. However, PELD yields similar clinical outcomes between obese and normal ALDH patients.
Placentome Size in Bos Taurus X Bos Indicus Crosses in the Mexican Tropics Differs From the Source Breeds
Authors: Bautista Nectalí Mendoza , Saavedra-Jiménez Luis Antonio , Sánchez-Santillán Paulino , Bottini-Luzardo Maria 
Published: June 2023

Abstract
Placentome size in cows can vary in response to many factors, including crossbreeding. We measured placentome size at different gestational ages in Bos taurus x Bos indicus cows raised in the tropics. Uteruses were collected immediately after slaughter from 102 cows with gestations ≥ 30 days and processed in the abattoir. All cows were Swiss Brown x Zebu phenotypes. Fetus gestational age was estimated by measuring from the crown to the tail base. Five placentomes were randomly chosen from each uterus (n = 510), and diameter (cm) measured for each. Gestational age was classified into nine categories (days): a) ≤ 45, b) > 45 ≤ 60, c) > 60 ≤ 90, d) > 90 ≤ 120, e) > 120 ≤ 150, f) > 150 ≤ 180, g) > 180 ≤ 210, h) > 210 ≤ 240 and i) > 240. Placentome size data was grouped by these categories. In all nine categories, placentome size was larger than reported for Bos taurus cows and smaller than reported in Bos indicus cows. This intermediate size suggests that existing gestational age reference tables based on placentome size for purebred cows are not applicable to Bos taurus x Bos indicus crosses.
Orthostatic Variation of Pulmonary Artery Pressure in Ambulatory Heart Failure Patients
Authors: Sethi Prince , Acharya Prakash , Lancaster Payton , Stack Brianna , Munshi Kartik , Ranka Sagar , Shah Zubair , Sauer Andrew J. , Gupta Kamal 
Published: June 2023

Abstract
Aim:
To study effect of change in position (supine and standing) on pulmonary artery pressure (PAP) in ambulatory heart failure (HF) patients.
Methods:
Seventeen patients with CardioMEMS® sensor and stable heart failure were consented and included in this single center study. Supine and standing measurements were obtained with at least 5 minutes interval between the two positions. These measurements included PAP readings utilizing the manufacturer handheld interrogator obtaining 10 second data in addition to the systemic blood pressure and heart rate recordings.
Results:
Mean supine and standing readings and their difference (Δ) were as follows respectively: Systolic PAP were 33.4 (± 11.19), 23.5 (± 10.1) and Δ was 9.9 mmHg (p = 0.006), diastolic PAP were 14.2 (± 5.6), 7.9 (± 5.7) and Δ was 6.3 mmHg (p = 0.001) and mean PAP were 21.8 (± 7.8), 14 (± 7.2) and Δ was 7.4 mmHg (p = 0.003) while the systemic blood pressure did not vary significantly.
Conclusion:
There is orthostatic variation of PAP in ambulatory HF patients demonstrating a mean decline with standing in diastolic PAP by 6.3 mmHg, systolic PAP by 9.9 mmHg and mean PAP by 7.4 mmHg in absence of significant orthostatic variation in systemic blood pressure or heart rate. These findings have significant clinical implications and inform that PAP in each patient should always be measured in the same position. Since initial readings at the time of implant were taken in supine position, it may be best to use supine position or to obtain a baseline standing PAP reading if standing PAP is planned on being used.
The Clinical relevance of Polygenic Risk Scores to Type 2 Diabetes Mellitus in Korean Population
Authors: Kim Na Yeon , Lee Haekyung , Kim Sehee , Kim Ye-Jee , Lee Hyunsuk , Lee Junhyeong , Kwak Soo Heon , Lee Seunggeun 
Published: June 2023

Abstract
The potential clinical utility of type 2 diabetes mellitus (T2DM) polygenic risk scores (PRS) is not thoroughly evaluated in the East Asian population. We aimed to assess whether T2DM PRS could have prognostic value and be used as a clinical instrument. We constructed T2DM PRS for Korean individuals using large East Asian Biobank data with samples of 269,487 and evaluated the PRS in a prospective longitudinal study of Korean with 5490 samples with baseline and additional seven follow-ups. Our analysis demonstrated that T2DM PRS could predict not only the progress from non-diabetes to T2DM, but also normal glucose tolerance to prediabetes and prediabetes to T2DM. Moreover, T2DM patients in the top decile PRS group were more likely to be treated with insulin with HR = 1.69 (p-value = 2.31E-02) than the remaining PRS groups. T2DM PRS was significantly high in severe diabetic subgroups with insulin resistance and \(\beta\)-cell dysfunction (p-value = 0.0012). PRS could modestly improve the prediction accuracy of the Harrel’s C-index by 9.88% (p-value < 0.001) in T2DM prediction models. By utilizing prospective longitudinal study data and extensive clinical risk factors, our analysis provides insights into the clinical utility of the T2DM PRS.
Enhanced Performance Of On-Chip Integrated Biosensor Using Deep Learning
Authors: Mikhail Thomas J. , Shamy Raghi El , Swillam Mohamed A. , Li Xun 
Published: June 2023

Abstract
A new approach for determining the concentration composition of a multi-element media using a micro-ring resonator (MRR) is proposed which allows for both electrical and thermal noise removal as well as moderately higher average accuracy. This method uses two neural networks, namely a convolutional neural network (CNN) and a deep neural network (DNN). The CNN differentiates the transmission spectrum from the noise. This spectrum is used to obtain selected features before being fed into the DNN, which determines the concentration of each chemical in the analyte. Both models are trained to work using simulated data from a silicon on-insulator ring resonator operating between the infrared wavelengths of λ=1.46 µm to λ=1.6 μm on mixtures of water, ethanol, methanol, and propanol, although the same approach can be used with other designs and substances. The CNN was trained using the MRR transmission spectra superimposed with white Gaussian noise as well as Poisson noise to mimic different noise sources, while the DNN underwent training on the extracted features. Average root-mean-square error for element concentration for the entire system is 0.083 % for a range of concentrations from 0.0357-0.75 %, and the largest error had a value of 0.68% concentration.
Awareness of Peri-Implantitis among General Dental Practitioners in the UK-A Questionnaire Study
Authors: Barrak Fadi , Thomas Sonu 
Published: June 2023

Abstract
Introduction: Dental Implants are a predictable prosthetic option for replacement of missing teeth with good survival rates. Peri-implant diseases are the main reason for implant failure by causing bone loss around the implant leading to implant loss. General dental practitioners see patients with dental implants routinely and therefore, awareness of risk factors for peri-implant disease and early diagnosis is essential for appropriate management. The aim of this study is to assess the awareness of general dental practitioners’ in diagnosing peri-implantitis with a view to identify any potential training needs.
Design, Setting, Materials and Methods: A quantitative study method was designed using an online questionnaire sent to closed social media groups in the UK. The significance level was taken as P<0.05. The Chi-square tests and Kruskal-Wallis tests were used with IBM SPSS software. Descriptive statistical analysis of data was also done.
Results and Conclusion: 224 responses were received in total. The results show that there is lack of awareness of diagnostic criteria of peri-implantitis among general dental practitioners. However, majority of practitioners are aware of the legal implications of failing to diagnose this condition. There is a perceived need for more undergraduate training in diagnosing peri-implant diseases.
USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2
Authors: Chen Yuanyuan , Guo Yunfei , Yuan Mei , Guo Song , Cui Shuaishuai , Chen Dahu 
Published: June 2023

AbstractBackground The pyruvate kinase enzyme PKM2 catalyzes the final step in glycolysis and converts phosphoenolpyruvate (PEP) to pyruvate. PKM2 is often overexpressed in cancer and plays a role in the Warburg effect. The expression of PKM2 can be regulated at different levels. While it has been proven that PKM2 can be regulated by ubiquitination, little is known about its de-ubiquitination regulation. Methods Immunoprecipitation was applied to identify the PKM2 interaction protein and to determine the interaction region between PKM2 and USP4. Immunofluorescence was performed to determine the cellular localization of USP4 and PKM2. The regulation of PKM2 by USP4 was examined by western blot and ubiquitination assay. MTT assays, glucose uptake, and lactate production were performed to analyze the biological effects of USP4 in gastric cancer cells. Results USP4 interacts with PKM2 and catalyzes the de-ubiquitination of PKM2. Overexpression of USP4 promotes cell proliferation, glucose uptake, and lactate production in gastric cancer cells. Knockdown of USP4 reduces PKM2 levels and results in a reduction in cell proliferation and the glycolysis rate. Conclusions USP4 plays a tumor-promoting role in gastric cancer cells by regulating PKM2.