bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential susceptibility of Red Sea Pocilloporidae corals to UVB highlights photoacclimation potential
Authors: Overmans Sebastian , Agustí Susana 
Published: March 2023

Despite being exposed to extreme water temperatures and solar irradiances, Red Sea corals are relatively resistant to bleaching. While their thermal tolerance is well described, little is known about their resistance to ultraviolet-B radiation (UVB). Here, we performed a short-term (2 days) UVB-removal incubation with Stylophora pistillata, and in situ measurements with Pocillopora verrucosa complemented by a long-term (46 days) transplantation and UVB-removal experiment. Using a suite of physiological parameters (effective quantum yield (Fv’/Fm’), oxidative stress (lipid peroxidation, LPO), and primary production), we assessed the impacts of UVB on the physiology and acclimation capacity of Red Sea corals. Shielding S. pistillata from UVB did not change the gross primary production or Fv’/Fm’, and respiration and LPO in the host remained unaffected. In situ, P. verrucosa exhibited less varying and significantly higher Fv’/Fm’ in 8 m depth (0.61 ± 0.04) than in 4 m (0.52 ± 0.06), 2 m (0.51 ± 0.09), and 0.5 m (0.50 ± 0.11), where water temperatures ranged from 30.5–33.4, 30.6–34.0, 30.8–34.5, 30.6–37.3°C and daily UVB exposures averaged 0.9, 2.9, 11.8 and 21.4 kJ m-2, respectively. Fv’/Fm’ correlated the strongest with UVB (-0.57), followed by PAR (-0.54) and temperature (-0.40), suggesting that UVB is a key determinant of photosynthetic efficiency. Fv’/Fm’ of upward transplanted specimens (T 1m) was initially decreased but gradually increased and reached the same values as shallow corals (1 m) after 44 days. UVB removal significantly increased the Fv’/Fm’ of transplanted corals in the first 20 days. Oxidative stress was initially highest in T 1m samples under full sunlight but equalized with 1 m specimens by day 46, whereas oxidative stress was significantly reduced by day 4 in T 1m corals sheltered from UVB. Overall, UVB-removal generally had little impact on the physiology of shallow-water S. pistillata and P. verrucosa but considerably accelerated the acclimation of upward transplanted corals. Our study highlights that UVB is a crucial stressor governing the photoacclimation capacity of these Red Sea coral species.
Poor insight and future thinking in early dementia limit patient projections of potential utility of technological innovations and advanced care planning
Authors: McLaren Jaye E. , Shin Marlena H. , Moo Lauren R. 
Published: March 2023

IntroductionCognitive psychology posits that thinking about the future relies on memory such that those with memory impairment may have trouble imaging their future technology and other needs.MethodsWe conducted a content analysis of qualitative data from interviews with six patients with MCI or early dementia regarding potential adaptations to a mobile telepresence robot. Using a matrix analysis approach, we explored perceptions of (1) what technology could help with day-to-day functioning in the present and future and (2) what technology may help people with memory problems or dementia stay home alone safely.ResultsVery few participants could identify any technology to assist themselves or other people with memory problems and could not provide suggestions on what technology may help them stay home alone safely. Most perceived that they would never need robotic assistance.DiscussionThese findings suggest individuals with MCI or early dementia have limited perspectives on their own functional abilities now and in the future. Consideration of the individuals’ diminished understanding of their own future illness trajectory is crucial when engaging in research or considering novel technological management solutions and may have implications for other aspects of advanced care planning.
Encoding of everyday objects in older adults: Episodic memory assessment in virtual reality
Authors: Pflueger Marlon O. , Mager Ralph , Graf Marc , Stieglitz Rolf-Dieter 
Published: March 2023

IntroductionAge-related decline in episodic memory performance in otherwise healthy older adults is indisputably evident. Yet, it has been shown that under certain conditions episodic memory performance in healthy older adults’ barely deviates from those seen in young adults. Here we report on the quality of object encoding in an ecologically valid, virtual-reality based memory assessment in a sample of healthy older and younger adults with comparable memory performance.MethodsWe analyzed encoding by establishing both a serial and semantic clustering index and an object memory association network.ResultsAs expected, semantic clustering was superior in older adults without need for additional allocation of executive resources whereas young adults tended more to rely on serial strategies. The association networks suggested a plethora of obvious but also less obvious memory organization principles, some of which indicated converging approaches between the groups as suggested by a subgraph analysis and some of which indicated diverging approaches as suggested by the respective network interconnectivity. A higher interconnectivity was observed in the older adults’ association networks.DiscussionWe interpreted this as a consequence of superior semantic memory organization (extent to which effective semantic strategies diverged within the group). In conclusion, these results might indicate a diminished need for compensatory cognitive effort in healthy older adults when encoding and recalling everyday objects under ecologically valid conditions. Due to an enhanced and multimodal encoding model, superior crystallized abilities might be sufficient to counteract an age-related decline in various other and specific cognitive domains. This approach might potentially elucidate age-related changes in memory performance in both healthy and pathological aging.
Temporal and periorbital depressions identified by 3D images are correlated with malnutrition phenotypes in cancer patients: A pilot study
Authors: Chen Moxi , Wang Xue , Han Meifen , Li Yunzhu , Yu Nanze , Long Xiao , Chen Wei 
Published: March 2023

BackgroundPrompt diagnosis of malnutrition and appropriate interventions can substantially improve the prognosis of patients with cancer; however, it is difficult to unify the tools for screening malnutrition risk. 3D imaging technology has been emerging as an approach to assisting in the diagnosis of diseases, and we designed this study to explore its application value in identifying the malnutrition phenotype and evaluating nutrition status.MethodsHospitalized patients treating with maintenance chemotherapy for advanced malignant tumor of digestive system were recruited from the Department of Oncology, whose NRS 2002 score &gt; 3. Physical examination and body composition data of patients at risk for malnutrition were analyzed by physicians trained to complete a subjective global assessment. The facial depression index was recognized using the Antera 3D® system, temporal and periorbital depression indexes were acquired using the companion software Antera Pro. This software captures quantitative data of depression volume, affected area, and maximum depth of temporal and periorbital concave areas.ResultsA total of 53 inpatients with malnutrition-related indicators were included. The volume of temporal depression was significantly negatively correlated with upper arm circumference (r = −0.293, p = 0.033) and calf circumference (r = −0.285, p = 0.038). The volume and affected area of periorbital depression were significantly negatively correlated with fat mass index (r = −0.273, p = 0.048 and r = −0.304, p = 0.026, respectively) and percent body fat (r = −0.317, p = 0.021 and r = −0.364, p = 0.007, respectively). The volume and affected area of temporal depression in patients with muscle loss phenotype (low arm circumference/low calf circumference/low handgrip strength/low fat-free mass index) were significantly higher than those in patients without muscle loss. Moreover, patients with fat mass loss phenotype (low fat mass index) showed a significant increase in the volume and affected area of periorbital depression.ConclusionThe facial temporal region, and periorbital depression indicators extracted by 3D image recognition technology were significantly associated with the phenotype of malnutrition-related muscle and fat loss and showed a trend of grade changes in the population of different subjective global assessment nutritional classifications.
Prediction of treatment response in patients with brain metastasis receiving stereotactic radiosurgery based on pre-treatment multimodal MRI radiomics and clinical risk factors: A machine learning model
Authors: Du Peng , Liu Xiao , Shen Li , Wu Xuefan , Chen Jiawei , Chen Lang , Cao Aihong , Geng Daoying 
Published: March 2023

ObjectivesStereotactic radiosurgery (SRS), a therapy that uses radiation to treat brain tumors, has become a significant treatment procedure for patients with brain metastasis (BM). However, a proportion of patients have been found to be at risk of local failure (LF) after treatment. Hence, accurately identifying patients with LF risk after SRS treatment is critical to the development of successful treatment plans and the prognoses of patients. To accurately predict BM patients with the occurrence of LF after SRS therapy, we develop and validate a machine learning (ML) model based on pre-treatment multimodal magnetic resonance imaging (MRI) radiomics and clinical risk factors.Patients and methodsIn this study, 337 BM patients were included (247, 60, and 30 in the training set, internal validation set, and external validation set, respectively). Four clinical features and 223 radiomics features were selected using least absolute shrinkage and selection operator (LASSO) and Max-Relevance and Min-Redundancy (mRMR) filters. We establish the ML model using the selected features and the support vector machine (SVM) classifier to predict the treatment response of BM patients to SRS therapy.ResultsIn the training set, the SVM classifier that uses a combination of clinical and radiomics features demonstrates outstanding discriminative performance (AUC=0.95, 95% CI: 0.93-0.97). Moreover, this model also achieves satisfactory results in the validation sets (AUC=0.95 in the internal validation set and AUC=0.93 in the external validation set), demonstrating excellent generalizability.ConclusionsThis ML model enables a non-invasive prediction of the treatment response of BM patients receiving SRS therapy, which can in turn assist neurologist and radiation oncologists in the development of more precise and individualized treatment plans for BM patients.
Host spatiotemporal overlap in a park with high endemicity of Echinococcus multilocularis
Authors: Visscher Darcy R. , Toews Emilie , Pattison Jesse , Walker Philip D. , Kemna Colborne , Musiani Marco , Massolo Alessandro 
Published: March 2023

BackgroundThere has been a spate of recent cases of human alveolar echinococcosis (AE) in Alberta, Canada. Alveolar echinococcosis is caused byEchinococcus multilocularis, which is prevalent among coyote populations and present in domestic dogs in Alberta.Methods and resultsUsing qPCR, we estimated the seasonal fecal prevalence ofE. multilocularisin coyotes and dogs in a multiuse recreation area close to Edmonton, Alberta, where we also setup remote cameras to model seasonal changes in the overlap in temporal activity and the spatial intensity of use among coyotes, humans, and dogs, as a proxy of potential transmission. We detectedE. multilocularisin 18 of 137 wild canid feces and none in 44 dog feces. After correcting for the qPCR test’s sensitivity and specificity, we estimated at 15.7% (9.7-22.7%, 95% CrI) the true fecal prevalence for coyotes. Temporal overlap between coyotes and both humans and dogs increased in the fall and winter relative to the spring and summer. Coyote intensity of use showed seasonal variations and was higher on maintained trails and locations closer to visitor parking and at sites with high intensity of dog use.ConclusionsOur results reinforce the need of an integrated approach, typical of both One-Health and Eco-Health, to park management for minimizing the likelihood of transmission where human and dog activity results in significant overlap with the one of the natural definitive hosts of zoonotic parasites.
The surgical techniques of transperineal anastomotic urethroplasty for complex posterior urethral stenosis in boys and the long-term follow up outcomes
Authors: Zhu Weidong , Song Lujie , Sa Yinglong , Xu Yuemin , Fu Qiang 
Published: March 2023

ObjectiveTo explored the curative effects of various surgical methods used to treat complicated posterior urethral strictures in boys and the long-term complication.MethodsWe retrospectively studied 28 boys under 14 years of age with complicated posterior urethral strictures treated at our hospital from January 2015 to December 2020. Urethral angiography revealed posterior urethral strictures. Twelve had previously failed urethral surgery; four had urethral fistulae. All underwent end-to-end urethral anastomoses via a transperineal, inferior pubic approach. We freed the distal end of the urethra, split the penile cavernous septum, partially resected the lower edge of the pubic symphysis, and rerouted the urethra under a corpus cavernosum to reduce the tension of the urethral anastomosis.ResultsAll boys were 2–14 years of age at the time of surgery (mean 6.3 years). The urethral strictures were 3–5.5 cm in length (mean 4.2 cm). Catheters were removed 4 weeks postoperatively. The postoperative follow-up time was 4–72 months (mean 36.8 months). Twenty-four patients exhibited unobstructed urination after a single operation. The maximum urinary flow rate was 15–22 ml/s (average 17.8 ml/s); the success rate was 85.7%. Two patients required second urethral end-to-end anastomoses; urination became normal postoperatively. Two continued to exhibit cystostomies, and two evidenced mild incontinence. Of the six children who have attained puberty, two report erectile dysfunction.ConclusionEnd-to-end urethral anastomosis via a transperineal inferior pubic approach is an ideal treatment for posterior urethral strictures in boys. The complications include incontinence and erectile dysfunction, and require long-term follow-up.
Perspectives on adaptive functioning and intellectual functioning measures for intellectual disabilities behavioral research
Authors: Mattie Laura J. , Loveall Susan J. , Channell Marie Moore , Rodgers Derek B. 
Published: March 2023

IntroductionIntellectual disability (ID) is a significant limitation in both intellectual ability and adaptive functioning, but many studies of participants with ID only include a measure of overall intellectual functioning when describing their samples. The purpose of this perspective article was to provide a starting point for future research regarding the utility of including measures of both intellectual and adaptive functioning in research focused on ID. In this article, we discuss the differences and similarities between the constructs of intellectual and adaptive functioning, how they are measured, and the benefits of using both measures to describe participant abilities. Data are presented to demonstrate that intellectual and adaptive functioning measures capture separate but related skills in a sample of individuals with ID (i.e., children with Down syndrome [DS]; the leading genetic cause of ID).MethodsThirty children with DS (7–31 months) were administered the Mullen Scales of Early Learning and their mothers were interviewed using the Vineland Adaptive Behavior Scales.ResultsAt the group level, Vineland and Mullen composite scores were relatively normally distributed and positively correlated. At the individual level, a concordance correlation coefficient indicated moderate agreement between Vineland and Mullen composite scores.DiscussionAlthough many children showed consistency between measures, others did not. Our discussion and findings, though preliminary, highlight that intellectual and adaptive functioning are separate but related skills and that there are benefits to including both measures when describing samples with ID. We discuss considerations for including adaptive functioning measures to enhance future research on individuals with ID.
“A frightening experience, especially at our age”: Examining the neglect and abuse of older persons in HIV prevention and care programs
Authors: Nyirenda Makandwe , Sukazi Sizakele , Buthelezi Cebo , Hanass-Hancock Jill 
Published: March 2023

BackgroundAs the global population ages and the HIV pandemic matures, a growing number of older persons aged ≥50 years are becoming increasingly vulnerable to acquiring HIV. Unfortunately, older persons are often neglected and left out of sexual health programs and services. This study explored the experiences of older persons living with and without HIV in accessing prevention and care services and how those experiences translate into the neglect and abuse of older persons. The study also explored older people's perspectives on community responses to HIV in older people.MethodsThis qualitative analysis used data from 37 individuals who participated in focus group discussions conducted in 2017/2018 across two communities in Durban, South Africa. Using an interview guide and thematic content analysis, salient themes regarding attitudes to HIV in older persons and factors of access to HIV prevention and cares services for older persons were analyzed.ResultsThe study participant's mean age was 59.6 years. Major themes emerging from the data included factors impacting HIV prevention and transmission in older people; community responses to HIV contributing to the abuse of older people, and structural drivers of abuse in older people living with HIV (OPLHIV). Knowledge about HIV and how to protect themselves from HIV was limited among participants. Older persons were frightened to acquire HIV at an older age as they feared judgment and discrimination for getting HIV at that age. OPLHIV reported frequently experiencing community stigma and poor staff attitudes and practices at health facilities, such as a triage health delivery system that fueled community stigma. Participants also experienced neglect, verbal and emotional abuse at healthcare facilities.ConclusionAlthough there were no reports of physical and sexual abuse of older persons in this study, this study shows that despite decades of HIV programs in the country, HIV-related stigma, discrimination, and disrespect of older persons remain pervasive in the community and at health facilities. As an increasing number of people age and live longer with HIV, the neglect and outright abuse of older persons need urgent policy and program interventions.
Hemoglobin level is negatively associated with sarcopenia and its components in Chinese aged 60 and above
Authors: Liu Qiaoling , You Jiuhong , Zhong Min , Wu Zhigang , Geng Yunjie , Huang Cheng 
Published: March 2023

IntroductionSarcopenia and low hemoglobin level are common in older adults. Few studies have evaluated the association between hemoglobin level and sarcopenia and with inconsistent findings. The multifaceted effects of sarcopenia on the human body and the high prevalence of anemia in the Chinese population make it necessary to explore the association between the two.MethodsUsing the China Health and Retirement Longitudinal Study (CHARLS), we explored the association between hemoglobin with sarcopenia and its components in the Chinese population aged 60 and above. Multivariate logistic and Cox proportional hazards models were constructed to examine the association of hemoglobin level with sarcopenia and sarcopenia components in individuals aged 60 years or above. The subgroup analysis covered residence, body mass index level, drinking status, and smoking status were conducted. The possible difference of associations between sexes was also explored.ResultsWith a total of 3,055 people, the hemoglobin concentration in people without sarcopenia, possible sarcopenia, and sarcopenia are 14.34 ± 2.22, 14.64 ± 2.27, and 13.58 ± 2.02 g/dl, respectively. Cross-sectional analysis showed strong evidence that hemoglobin was negatively associated with sarcopenia [Odds Ratio (OR) = 0.95, 95% Confidence Interval (CI): 0.90–0.99] and low height-adjusted appendicular skeletal muscle mass (OR = 0.91, 95% CI: 0.86–0.97). On average, a per 1 g/dl higher hemoglobin level was associated with 5% lower odds of sarcopenia (OR = 0.95, 95% CI: 0.90–0.98). The cohort study of 1,022 people demonstrated a statistically significant negative association of hemoglobin level with low physical performance [Hazard Ratio (HR) = 0.92, 95% CI: 0.85–0.99], merely with sarcopenia (HR = 0.92, 95% CI: 0.84–1.00) and skeletal muscle mass (HR = 0.95, 95% CI: 0.80–1.00). Sex-specific analysis suggested hemoglobin's association with sarcopenia, muscle mass, and physical performance in all sexes, with weaker magnitudes in females. Hemoglobin in urban residents and people with high body mass index (BMI) has a larger magnitude of the negative association with sarcopenia.DiscussionHemoglobin level associates with sarcopenia, muscle mass, and physical performance in the Chinese population aged 60 and above, with sex-specific, residence-specific, and BMI-specific effects.
What is the degree of social disability risk in China under the background of the aging population? Social disability risk measurement index system design and evaluation research based on China
Authors: Guo Qianqian , Sun Yufeng , Fan Miao , Li Zhichun 
Published: March 2023

ObjectiveThe impact of the aging population in China varies between regions. It is because regions with different resource endowments, such as those related to economy, population, and medical care, have different degrees of disability risk in the face of the increases in the disabled and semi-disabled older population caused by the overall aging of the population. This study aimed to construct an evaluation system to monitor and measure the degree of social disability risk in different regions in China and to evaluate and compare the degree of social disability risk in different regions using empirical data.MethodThis study used the Delphi method to construct a social disability risk measurement index system with macro, meso, and micro dimensions. At the same time, based on the data of CHARLS2018, an AHP-entropy method was used to calculate the index's total weight, and the standard deviation classification method was used to classify the total and criterion-level measurement scores of 28 provinces.ResultsThe regional degree of social disability risk was analyzed in subdimensions. Our research indicates that China's social disability risk situation is not promising, with a general medium to high-risk level. The score of degree of social disability risk among provinces is consistent with the regional economic development level to a large extent. The risk of social disability varies significantly among the eastern and central, and western regions of China and the provinces within the three regions.DiscussionCurrently, the situation facing the degree of social disability risk in China is that the overall risk level of the country is higher, and the difference between regions is significant. It is necessary to take measures to meet better the needs of the aging population and the disabled and semi-disabled older populations in a large-range, large-scale, multilevel way.