bluuebunny/crossref_metadata_2025_split huggingface dataset:
CT required to perform robotic-assisted total hip arthroplasty can identify previously undiagnosed osteoporosis and guide femoral fixation strategy
Authors: Bukowski Brett R. , Sandhu Kevin P. , Bernatz James T. , Pickhardt Perry J. , Binkley Neil , Anderson Paul A. , Illgen Richard 
Published: March 2023

AimsOsteoporosis can determine surgical strategy for total hip arthroplasty (THA), and perioperative fracture risk. The aims of this study were to use hip CT to measure femoral bone mineral density (BMD) using CT X-ray absorptiometry (CTXA), determine if systematic evaluation of preoperative femoral BMD with CTXA would improve identification of osteopenia and osteoporosis compared with available preoperative dual-energy X-ray absorptiometry (DXA) analysis, and determine if improved recognition of low BMD would affect the use of cemented stem fixation.MethodsRetrospective chart review of a single-surgeon database identified 78 patients with CTXA performed prior to robotic-assisted THA (raTHA) (Group 1). Group 1 was age- and sex-matched to 78 raTHAs that had a preoperative hip CT but did not have CTXA analysis (Group 2). Clinical demographics, femoral fixation method, CTXA, and DXA data were recorded. Demographic data were similar for both groups.ResultsPreoperative femoral BMD was available for 100% of Group 1 patients (CTXA) and 43.6% of Group 2 patients (DXA). CTXA analysis for all Group 1 patients preoperatively identified 13 osteopenic and eight osteoporotic patients for whom there were no available preoperative DXA data. Cemented stem fixation was used with higher frequency in Group 1 versus Group 2 (28.2% vs 14.3%, respectively; p = 0.030), and in all cases where osteoporosis was diagnosed, irrespective of technique (DXA or CTXA).ConclusionPreoperative hip CT scans which are routinely obtained prior to raTHA can determine bone health, and thus guide femoral fixation strategy. Systematic preoperative evaluation with CTXA resulted in increased recognition of osteopenia and osteoporosis, and contributed to increased use of cemented femoral fixation compared with routine clinical care; in this small study, however, it did not impact short-term periprosthetic fracture risk.Cite this article: Bone Joint J 2023;105-B(3):254–260.
Interleukin6 prediction of mortality in critically ill COVID19 patients: A prospective observational cohort study
Authors: Jamoussi Amira , Messaoud Lynda , Jarraya Fatma , Rachdi Emna , Ben Mrad Nacef , Yaalaoui Sadok , Besbes Mohamed , Ayed Samia , Ben Khelil Jalila 
Published: March 2023

Objective
The aim of this study is to explore the role of IL6 in predicting outcome in critically ill COVID-19 patients. Design Prospective observational cohort study. Setting 20-bed respiratory medical intensive care unit of Abderrahmen Mami Teaching Hospital between September and December 2020.

Methods
We included all critically ill patients diagnosed with COVID-19 managed in ICU. IL6 was measured during the first 24 hours of hospitalization.

Results
71 patients were included with mean age of 64 ± 12 years, gender ratio of 22. Most patients had comorbidities, including hypertension (n = 32, 45%), obesity (n = 32, 45%) and diabetes (n = 29, 41%). Dexamethasone 6 mg twice a day was initiated as treatment for all patients. Thirty patients (42%) needed high flow oxygenation; 59 (83%) underwent non-invasive ventilation for a median duration 2 [1–5] days. Invasive mechanical ventilation was required in 44 (62%) patients with a median initiation delay of 1 [0–4] days. Median ICU length of stay was 11 [7–17] days and overall mortality was 61%. During the first 24 hours, median IL6 was 34.4 [12.5–106] pg/ml. Multivariate analysis shows that IL-6 ≥ 20 pg/ml, CPK < 107 UI/L, AST < 30 UI/L and invasive ventilation requirement are independent risk factors for mortality.

Conclusions
IL-6 is a strong mortality predictor among critically ill COVID19 patients. Since IL-6 antagonist agents are costly, this finding may help physicians to consider patients who should benefit from that treatment.
Practice environment determinants of job satisfaction among midwives at healthcare facilities in Accra Metropolis: A multicentre study
Authors: Aikins Dorothy Akua , Poku Collins Atta , Donkor Ernestina , Naab Florence 
Published: March 2023

Introduction
Sustainable Development Goal 3 (SDG 3) has been one of the key goals for all partners of health globally. The health workforce especially midwives are among the principal skilled experts for achieving the goal. This is evidenced in the role they play in caring for pregnant women from the antenatal stages to the postpartum periods. However, very little has been reported about midwives’ job satisfaction in Ghana. The study assessed the practice environment determinants of job satisfaction among registered midwives in Ghana.

Materials and methods
A cross-sectional design was adopted to recruit midwives from public and quasi-government hospitals in Accra Metropolis. Validated scales—‘Measure of Job Satisfaction’ and ‘Practice Environment Scale of Nursing Work Index’ were used for data collection. Data was analysed through descriptive statistics, Pearson correlation and linear regression.

Results
Midwives had a positive perception of their work environment. They were generally satisfied with their job but were dissatisfied with their salaries. Key determinants of midwives’ job satisfaction included years of work as a midwife, managers’ leadership and support, and adequacy of human and material resources.

Conclusion
Improving midwives’ job satisfaction through enabling the work environment will go a long way to improve healthcare provision in the healthcare delivery points in helping achieve SDG 3.
Problemas, retos y oportunidades en los Archivos de Arquitectura
Authors: Carrascal Andreu 
Published: March 2023

Los archivos de arquitectura son una tipología rica y diversa. Sus formatos, representaciones gráficas, dimensiones o afectaciones jurídicas los hacen especiales e inciden en su gestión. Los Archivos de Arquitectura son las principales instituciones que velan por esta documentación, con retos importantes en el presente y futuro
Effect of Infiltration Ce0.8Sm0.2O1.9 Against Double Perovskite Performance LaBa0.5Sr0.5Co2O5+δ as IT-SOFC Cathode
Authors: Subardi Adi , Fu Yen-Pei 
Published: March 2023

Modifying the sample surface by infiltration technique using Ce0.8Sm0.2O1.9 (SDC) electrolyte has been done to increase the catalytic activity of the LaBa0.5Sr0.5Co2O5+δ (LBSC) cathode. The cathode powder structure was evaluated using X-ray diffraction (XRD) at room temperature, and the LBSC cathode microstructure was analyzed using scanning electron microscopy (SEM). The electrical conductivity of the LBSC cathode was tested using the four-probe DC method. Symmetrical cells were tested using a potentiostat Voltalab PGZ 301 and a digital source meter Keithley 2420. LBSC powder was discovered to have a tetragonal structure (space group: P4/mmm) with lattice parameters of a = 3.86253 Å, c = 7.73438 Å, and V = 115.338 Å. From the SEM image, the LBSC cathode has homogeneous, dense, and highly porous grains. The electrical conductivity showed metallic behavior, gradually decreasing from 167 S.cm-1 at 300℃ to 105 S.cm-1 at 800℃. A significant increase in current density (io) of 275% occurred at 800℃ from 154.10 mA.cm−2 (pure LBSC) to 577.86 mA.cm−2 (LBSC+0.5M SDC). The activation energy value (Ea) of symmetrical cells was determined using electrochemical impedance spectroscopy (EIS), low-field (LF), and high-field (HF) techniques. The activation energy of the LBSC+0.5 M SDC specimen was 47.9 kJ mol-1 or 79.4% lower than the activation energy of the LBSC cathode specimen without infiltration at atmospheric pressure of 0.03 atm. These results indicate that SDC infiltration of the LBSC cathode can reduce the activation energy of the signiﬁcant. The cathode membrane adheres quite well to the electrolyte membrane, the cathode porosity varies in the range of 1–4 µm, and the grain size is 0.1–1.5 µm.
Comparison of immunotherapy combined with stereotactic radiotherapy and targeted therapy for patients with brain metastases: A systemic review and meta-analysis
Authors: Su Zhou , Zhang Li , Xue Shaolong , Wang Youke , Ding Ruining 
Published: March 2023

Abstract
Advances in brain imaging have led to a higher incidence of brain metastases (BM) being diagnosed. Stereotactic radiotherapy (SRS), systemic immunotherapy, and targeted drug therapy are commonly used for treating BM. In this study, we summarized the differences in overall survival (OS) between several treatments alone and in combination. We carried out a systematic literature search on Pubmed, EMBASE, and Cochrane Library. Differences in OS associated with Immune checkpoint inhibitors (ICI) alone versus targeted therapy alone and SRS + ICI or ICI alone were evaluated. This analysis was conducted on 11 studies involving 4,154 patients. The comprehensive results of fixed effect model showed that the OS of SRS + ICI group was longer than that of the ICI group (hazard ratio, 1.72; 95% CI: 1.41–2.11; P = 0.22; I
2 = 30%). The combined fixed-effect model showed that the OS time of ICI was longer than that of targeted therapy (hazard ratio, 2.09; 95% CI: 1.37–3.20; P = 0.21; I
2 = 35%). The study had a low risk of bias. In conclusion, our analysis confirmed that immunotherapy alone showed a higher OS benefit in BM patients than targeted therapy alone. The total survival time of patients with SRS combined with ICI was higher than that of patients with single ICI.
A new door to a different world: opportunities from the metaverse and the raise of meta-medical laboratories
Authors: Gruson Damien , Greaves Ronda , Dabla Pradeep , Bernardini Sergio , Gouget Bernard , Öz Tuğba Kemaloğlu 
Published: March 2023

Abstract

Objectives
In the digital age, the metaverse has emerged with impressive potential for many segments of society. The metaverse could be presented as a parallel dimension able to enhance the physical world as well as our actions and decisions in it with the objective to use a coalition between the natural and virtual worlds for value creation. Our aim was to elaborate on the impact of the metaverse on laboratory medicine.

Methods
Based on the available evidence, literature and reports, we analyzed the different perspectives of the metaverse on laboratory medicine and the needs for an efficient transition.

Results
The convergence and integration of technologies in the metaverse will participate to the reimagination of laboratory medicine services with augmented services, users’ experiences, efficiency, and personalized care. The revolution around the metaverse offers different opportunities for laboratory medicine but also open multiple related challenges that are presented in this article.

Conclusions
Scientific societies, multidisciplinary teams and specialists in laboratory medicine must prepare the integration metaverse and meta-medical laboratories, raise the awareness, educate, set guidance to obtain a maximum of value and mitigate potential adverse consequences.
Graphene quantum dots: A comprehensive overview
Authors: Sheikh Mohd Ghazali Sheikh Ahmad Izaddin , Fatimah Is , Zamil Zaireen Natasya , Zulkifli Nur Nadia , Adam Nurain 
Published: March 2023

Abstract
Because of their prospective applications and exceptional features, graphene quantum dots (GQDs) have gotten a lot of recognition as a new class of fluorescent carbon materials. One of the carbon family’s newest superstars is the GQD. Due to its exceptional optoelectrical qualities, it has sparked a lot of curiosity since its debut in 2008. Two of the most important traits are a band gap that is not zero, biocompatibility, and highly changeable characteristics. GQDs have several important characteristics. GQDs have shown potential in a variety of fields, for instance, catalysis, sensing, energy devices, drug delivery, bioimaging, photothermal, and photodynamic therapy. Because this area constantly evolves, it is vital to recognize emerging GQD concerns in the current breakthroughs, primarily since some specific uses and developments in the case of GQDs synthesis have not been thoroughly investigated through previous studies. The current results in the properties, synthesis, as well as benefits of GQDs are discussed in this review study. As per the findings of this research, the GQD’s future investigation is boundless, mainly if the approaching investigation focuses on purifying simplicity and environmentally friendly synthesis, as well as boosting photoluminescence quantum output and manufacturing output of GQDs.
Point-of-care salivary oxidative and renal functional markers to assess kidney function in reperfusion-induced acute kidney injury in male rats
Authors: Abdi Arash , Kadkhodaee Mehri , Seifi Behjat , Kianian Farzaneh , Lorian Keivan , Shams Sedigheh , Bakhshi Enayatollah , Ashabi Ghorbangol , Ranjbaran Mina 
Published: March 2023

Abstract

Objectives
Saliva is one of the most promising body fluids in the research of new biomarker for various diseases diagnosis. However, serial sampling in this condition is very dangerous and pose iatrogenic anemia with blood loss. This study was done to evaluate the cost-effectiveness of point-of-care salivary tests and identify the validity of salivary markers.

Methods
Rats were randomly assigned to four experimental groups: (1) control (2) IR-3 h (3) IR-6 h (4) IR-24 h. Both renal pedicles were occluded for 55 min and then were declamped to allow reperfusion for 3, 6 and 24 h in IR groups. After reperfusion, all rats received pilocarpine 1 mg/kg to collect saliva. Plasma samples were also collected. Renal parameters including Cr, uric acid, and urea, malondialdehyde (MDA) levels, Bax/Bcl2 ratio, nitrite/nitrate ratio, corticosterone levels and oxidant/antioxidant ratio were measured in both plasma and salivary samples.

Results
There were significant increased level of renal function parameters, MDA levels, Bax/Bcl2 ratio, nitrite/nitrate ratio and corticosterone in both saliva and plasma. The comparison of above parameters in both saliva and plasma showed significant correlation.

Conclusions
This study demonstrated that concentrations of indices specifically renal functional parameters increase in saliva in the IR-induced kidney injury in male rats and result indicate the potential of saliva as a tool to monitoring AKI. Measurement of salivary parameters may can become reliable diagnostic tests for patients with AKI.
El conflicto rural en la Amazonía
Authors: Sánchez Cortes Jacqueline 
Published: March 2023

El conflicto social en la Amazonía ha sido una vivencia de alta complejidad con hechos que afectan su población. En este punto, las políticas rurales antes y después del acuerdo de paz no han podido responder a la problemática social de estos territorios ocupados y a la dignificación de una violencia causada por los grupos al margen de la ley. El texto pretende dar respuesta a las siguientes preguntas: ¿Qué tipo de conflicto enfrentan los campesinos en la Amazonía?, ¿Cómo inciden las políticas rurales en el conflicto campesino de la Amazonía? y ¿hay un equilibrio entre la problemática campesina y las políticas rurales? Para concluir, se plantea una opinión y síntesis reflectiva de estos escenarios.
Limited Utility of Toxicology Testing at Delivery for Perinatal Cannabis Use
Authors: Sarathy Leela , Chou Joseph H. , Lerou Paul H. , Terplan Mishka , Mark Katrina , Dorfman Sarah , Wilens Timothy E. , Bernstein Sarah N. , Schiff Davida M. 
Published: March 2023

OBJECTIVES
To describe the characteristics of individuals undergoing toxicology testing at delivery for a sole indication of cannabis use and to evaluate the rate of unexpected positive toxicology testing results among this cohort.

METHODS
This retrospective cohort study included dyads with a maternal history of cannabis use who underwent peripartum toxicology testing between 2016 and 2020 at 5 birthing hospitals in Massachusetts. We collected information on maternal demographic characteristics and toxicology test results and reviewed records of dyads with unexpected positive results to identify additional social risk factors and clinical outcomes.

RESULTS
Of 60 608 live births reviewed, 1924 dyads underwent toxicology testing, including 614 (31.9%) for a sole indication of cannabis use. Significantly greater percentages of patients in the cannabis cohort were &lt;25 years old (32.4% vs 6.1% of the birthing population, P &lt;.001), non-Hispanic Black (32.4% vs 8.1%, P &lt; .001), Hispanic or Latino (30.5% vs 15.5%), American Indian/Alaskan (0.7% vs 0.1%), and publicly insured (39.9% vs 15.6%, P &lt;.001). Eight of the 614 dyads (1.3%) had an unexpected positive toxicology test result, including 2 (0.3%) unexpectedly positive for opioids. Seven dyads (1.1%) had false positive test results for unexpected substances. Only 1 test result changed clinical management; a urine test positive for opioids prompted monitoring (but not medication) for neonatal opioid withdrawal syndrome.

CONCLUSIONS
Toxicology testing of patients for a sole indication of cannabis use, without other risk factors, may be of limited utility in elucidating other substance use and may exacerbate existing disparities in perinatal outcomes.
Mathematical nuances of Gaussian process-driven autonomous experimentation
Authors: Noack Marcus M. , Reyes Kristofer G. 
Published: March 2023

AbstractThe fields of machine learning (ML) and artificial intelligence (AI) have transformed almost every aspect of science and engineering. The excitement for AI/ML methods is in large part due to their perceived novelty, as compared to traditional methods of statistics, computation, and applied mathematics. But clearly, all methods in ML have their foundations in mathematical theories, such as function approximation, uncertainty quantification, and function optimization. Autonomous experimentation is no exception; it is often formulated as a chain of off-the-shelf tools, organized in a closed loop, without emphasis on the intricacies of each algorithm involved. The uncomfortable truth is that the success of any ML endeavor, and this includes autonomous experimentation, strongly depends on the sophistication of the underlying mathematical methods and software that have to allow for enough flexibility to consider functions that are in agreement with particular physical theories. We have observed that standard off-the-shelf tools, used by many in the applied ML community, often hide the underlying complexities and therefore perform poorly. In this paper, we want to give a perspective on the intricate connections between mathematics and ML, with a focus on Gaussian process-driven autonomous experimentation. Although the Gaussian process is a powerful mathematical concept, it has to be implemented and customized correctly for optimal performance. We present several simple toy problems to explore these nuances and highlight the importance of mathematical and statistical rigor in autonomous experimentation and ML. One key takeaway is that ML is not, as many had hoped, a set of agnostic plug-and-play solvers for everyday scientific problems, but instead needs expertise and mastery to be applied successfully.
Graphical abstract
ANALISA DAMPAK REVALUASI ASET TETAP TERHADAP HARGA PASAR DAN RETURN SAHAM YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Puspitasari Dwi Puspitasari , Anggraeni Lukytawati , Pasaribu Syamsul Hidayat 
Published: March 2023

Abstract. The objective of this study is to examine the impact of fixed asset revaluation towards market reaction proxied by stock price and stock return of public listed company in Indonesia Stock Exchange in the period of 2007 until 2016. Revaluation is one of valuation methode of fixed asset used to give more accuracy and fair information about the the condition of the company for those interested parties. The samples in this research used 18 companies which applied revaluation method were selected by purposive sampling technique. The method of analysis in this study using regression analysis. This study showed fixed asset revaluation is not significant influence to the stock price and stock return. These results have practical implication to corporate manager for financial strategy for increasing the value of the company. Keywords: Fixed assets revaluation, stock price, stock return Abstrak. Penelitian ini bertujuan untuk meneliti pengaruh revaluasi aset tetap terhadap reaksi pasar yang ditunjukan dengan harga pasar saham perusahaan publik yang terdaftar di Bursa Efek Indonesia selama tahun 2007 sampai 2016. Revaluasi merupakan salah satu metode penilaian aset tetap yang bertujuan untuk memberikan informasi yang akurat dan wajar tentang kondisi perusahaan kepada pihak yang membutuhkan. Sampel pada penelitian ini menggunakan 18 perusahaan yang menerapkan metode revaluasi yang dipilih dengan metode purposive sampling. Metode analisa dalam penelitian ini menggunakan analisa regresi. Hasil penelitian ini menunjukan bahwa revaluasi aset tetap tidak berpengaruh signifikan terhadap harga pasar dan return saham. Hasil penelitian ini memberikan implikasi kepada manajemen untuk strategi keuangan dalam meningkatkan nilai perusahaan. Kata Kunci: Revaluasi aset tetap, harga pasar saham, return saham
ANALISIS FAKTOR YANG MEMPENGARUHI AKUNTABILITAS PENGELOLAAN ALOKASI DANA DESA (Studi Kasus pada Kecamatan Yosowilangun Kabupaten Lumajang)
Authors: Yesinia Nur Ida , Yuliarti Norita Citra , Puspitasari Dania 
Published: March 2023

Abstract. The purpose of this study is to describe and analyze the factors that influence the accountability of village fund allocation management (case study in Yosowilangun District, Lumajang District). The formulation of the research problem is: (1) The role of village apparatus influences the accountability of village fund allocation management in Yosowilangun District, Lumajang District. (2) The village internal control system influences the accountability of village fund allocation management in Yosowilangun District, Lumajang District. The research method used is quantitative research with data analysis techniques in this study using multiple linear regression with SPSS 23 software tools. The sample in the study amounted to 42 respondents. The sampling technique uses saturated samples. The results of the study stated that: (1) the role of the village apparatus had a positive and significant effect on the accountability of village fund allocation management in Yosowilangun District, Lumajang District, (2) the internal control system had a positive and significant effect on the accountability of village fund allocation management in Yosowilangun District Lumajang District.Keywords: the role of village device, internal control system, accountability of village fund allocation management Abstrak. Tujuan penelitian ini yaitu mendeskripsikan dan menganalisis faktor yang mempengaruhi akuntabilitas pengelolaan alokasi dana desa (studi kasus pada Kecamatan Yosowilangun Kabupaten Lumajang). Rumusan masalah penelitian yaitu: (1) Peran perangkat desa berpengaruh terhadap akuntabilitas pengelolaan alokasi dana desa di Kecamatan Yosowilangun Kabupaten Lumajang. (2) Sistem pengendalian internal desa berpengaruh terhadap akuntabilitas pengelolaan alokasi dana desa di Kecamatan Yosowilangun Kabupaten Lumajang. Metode penelitian yang digunakan yaitu penelitian kuantitatif dengan teknik analisis data dalam penelitian ini menggunakan regresi linier berganda dengan alat bantu software SPSS 23.. Sampel pada penelitian berjumlah 42 responden. Teknik pengambilan sampel menggunakan sampel jenuh. Hasil penelitian menyatakan bahwa: (1) peran perangkat desa berpengaruh positif dan signifikan terhadap akuntabilitas pengelolaan alokasi dana desa di Kecamatan Yosowilangun Kabupaten Lumajang, (2) sistem pengendalian internal berpengaruh positif dan signifikan terhadap akuntabilitas pengelolaan alokasi dana desa di Kecamatan Yosowilangun Kabupaten Lumajang.Kata Kunci: peran perangkat desa, sistem pengendalian internal, akuntabilitas pengelolaan anggaran dana desa