bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘They Might Not Kill You Today but They’re Going to Get You in the End’: The Correctional Subculture and the Schematization of Danger
Authors: Higgins Ethan M , Swartz Kristin , Navarro John C , Hughes Katie 
Published: January 2023

Abstract
Criminology has long investigated criminal justice cultures and their preoccupation with dangerousness. Over a half century ago, correctional scholars called for a richer understanding of how a ‘social reality’ of danger might shape the mental state of staff. More recently, correctional scholarship has demonstrated that correctional culture and perceptions of danger likely play a fundamental role in findings that staff experience conflict across domains. Drawing from 18 focus groups of correctional staff from all adult carceral facilities in one state, this study investigates: 1) how cultural workgroup concerns over danger and values of safety shape staff’s worldview broadly; and, 2) how these worldviews concerning danger shape cultural cognition outside the carceral context. To answer these questions, we draw upon cultural sociology and leverage the mechanism of the schema to understand how values are recalled across domains. Through this analysis, we illustrate how an accumulation of stories concerning danger within prison shapes a worldview that structures compulsive cognition around personal safety. We show how compulsive cognition manifests as an intrinsic knowledge of the dangerous character of others and a personal drive to fortify against underspecified violent threats outside the carceral context.
The Importance of Connection: A Quantitative Study of Students’Learning in Placements Completed Remotely from an Organisation
Authors: Zuchowski Ines , Cleak Helen , Jefferson Grace 
Published: January 2023

Abstract
This quantitative study surveyed eighty-two Australian social work students who completed their placement during COVID-19. The delivery of health and welfare services during the pandemic had a significant impact on field education with the result that many placements had to be offered remotely from an organisation. The research was interested in whether this practice learning model can provide quality learning experiences for students by exploring various aspects of the placement experience. Frequency data were generated and the data were analysed using chi-square tests to determine, firstly, if there were any statistically significant relationships between student learning outcomes and model of supervision, supervisor contact, type of e-placement and student demographics. Secondly, the various learning activities were rated against the students' attainment of their placement learning oucomes and their developing confidence, skills and social work identity. Findings highlight that student learning is enhanced when they have opportunities to experience work within an agency setting and when agency staff are involved in supervising and supporting students in e-placements. There were also indications of negative learning outcomes when students are not provided with direct observation opportunities of agency staff and some evidence that e-placements might be more suitable for second placement students.
Eligibility for sotagliflozin in a real-world heart failure population based on the SOLOIST-WHF trial enrolment criteria: data from the Swedish heart failure registry
Authors: Becher Peter Moritz , Savarese Gianluigi , Benson Lina , Dahlström Ulf , Karlström Patric , Mol Peter G M , Metra Marco , Bhatt Deepak L , Pitt Bertram , Lund Lars H 
Published: January 2023

Abstract

Aims
The SOLOIST-WHF trial demonstrated efficacy of sotagliflozin in patients with type 2 diabetes mellitus (T2DM) and recent worsening heart failure (HF) regardless of ejection fraction (EF). Selection criteria in trials may limit their generalizability. Therefore, we aimed to investigate eligibility for sotagliflozin based on the SOLOIST-WHF criteria in a real-world HF population.

Methods and results
SOLOIST-WHF criteria were applied to patients stabilized after HF hospitalization in the Swedish HF Registry according to (i) literal scenario (all inclusion/exclusion criteria) or (ii) pragmatic scenario (only criteria likely to influence treatment decisions). Of 5453 inpatients with T2DM and recent worsening HF, 51.4% had reduced EF (HFrEF), 19.1% mildly reduced (HFmrEF), and 29.5% preserved EF (HFpEF). Eligibility (literal) was: 27.2% (32.4% in HFrEF, 24.7% in HFmrEF, 19.7% in HFpEF) and eligibility (pragmatic) was 62.8% (69.1%, 60.3%, 53.4%, respectively). In the literal scenario, criteria limiting eligibility were HF duration &lt;3 months, eGFR &lt;30 ml/min/1.73 m2, age &gt;85 years, acute coronary syndrome &lt;3 months, and insufficiently high N-terminal pro-B-type natriuretic peptide levels. Eligible vs. non-eligible patients had more severe HF, higher cardiovascular (CV) comorbidity burden, higher use of HF treatments, and higher event rates (all-cause death 30.8 vs. 27.2 per 100 patient-years, CV death 19.1 vs. 16.6, and HF hospitalization 36.7 vs. 24.0).

Conclusion
In this large, real-world HF cohort with T2DM, ∼1/3 of patients were eligible for sotagliflozin in the literal and ∼2/3 of patients in the pragmatic scenario. Eligible patients had more severe HF and higher event rates, in particular CV and HF events.
Persistence of foetal testicular features in patients with defective androgen signalling
Authors: Al-Sharkawi Mostafa , Calonga-Solís Verónica , Dressler Franz F , Busch Hauke , Hiort Olaf , Werner Ralf 
Published: February 2023

Abstract

Objective
Congenital defects of androgen synthesis or action in 46,XY individuals can result in impaired virilisation, despite the apparent testicular development. In a recent case, report of a young adult with complete androgen insensitivity syndrome (CAIS), tumourous gonadal tissue was shown to express HSD17B3 in Sertoli cells (SCs) and not in Leydig cells (LCs). This expression pattern differs from the typical adult human testis and resembles a foetal mouse testis, suggesting an underlying testicular development and function defect. Here, we investigate the effect of altered androgen signalling in gonads from five 46,XY individuals with defects in androgen synthesis or action.

Methods
Gonadal tissue sections from four patients with CAIS, one with CYP17A1 deficiency, and one control were immunostained for LC developmental and steroidogenic markers. The expression of some of these markers during development was investigated by reanalysing previously published single-cell RNA sequencing (scRNA-seq) data from normal human testicular tissues.

Results
All gonadal tissues from the patients show an exclusive expression of HSD17B3 in SCs and an expression of the foetal/immature LC marker DLK1 in a subset of LCs, suggesting an androgen-dependent differentiation defect of adult SCs and LCs. Furthermore, reanalysis of scRNA-seq data reveals an expression of HSD17B3 in foetal and neonatal SCs that is downregulated in adult SCs.

Conclusions
Androgen signalling may affect the differentiation of adults, but possibly not foetal SCs or LCs, and may induce a shift of testosterone production from the tubular compartment in the foetal phase to the interstitial compartment in the adult phase.
Self-management and hospitalization in 615 Swedish patients with Addison's disease during the coronavirus disease 2019 pandemic: a retrospective study
Authors: Öster Sara , Esposito Daniela , Aranda-Guillén Maribel , Åkerman Anna-Karin , Wahlberg Jeanette , Husebye Eystein Sverre , Kämpe Olle , Botusan Ileana Ruxandra , Dahlqvist Per , Bergthorsdottir Ragnhildur , Bensing Sophie 
Published: February 2023

AbstractObjectiveAutoimmune Addison's disease (AAD) entails a chronic adrenal insufficiency and is associated with an increased risk of severe infections. It is, however, unknown how patients with AAD were affected by the coronavirus disease 2019 (COVID-19) pandemic of 2020-2021. This study was aimed at investigating the incidence of COVID-19 in patients with AAD in Sweden, the self-adjustment of medications during the disease, impact on social aspects, and treatment during hospitalization. Additionally, we investigated if there were any possible risk factors for infection and hospitalization.Design and methodsQuestionnaires were sent out from April to October 2021 to 813 adult patients with AAD in the Swedish Addison Registry. The questionnaires included 55 questions inquiring about COVID-19 sickness, hospital care, medications, and comorbidities, focusing on the pre-vaccine phase.ResultsAmong the 615 included patients with AAD, COVID-19 was reported in 17% of which 8.5% required hospital care. Glucocorticoid treatment in hospitalized patients varied. For outpatients, 85% increased their glucocorticoid dosage during sickness. Older age (P = .002) and hypertension (P = .014) were associated with an increased risk of hospital care, while younger age (P &lt; .001) and less worry about infection (P = .030) were correlated with a higher risk of COVID-19.ConclusionsIn the largest study to date examining AAD during the COVID-19 pandemic, we observed that although one-fifth of the cohort contracted COVID-19, few patients required hospital care. A majority of the patients applied general recommended sick rules despite reporting limited communication with healthcare during the pandemic.
Race–Ethnicity and Depressive Symptoms Among U.S. Older Adults in the COVID-19 Pandemic: Uncovering the Counterbalancing Mechanisms
Authors: Li Miao , Luo Ye 
Published: January 2023

AbstractBackground and ObjectivesDrawing on the counterbalancing framework, this study examined the counteracting roles of coronavirus disease (COVID)-related stressors (i.e., infection threat, family activity disruption, economic impact) and psychological resilience in explaining racial–ethnic disparities in depressive symptoms during the COVID-19 pandemic.Research Design and MethodsA competitive mediation model was fitted using nationally representative data from the Health and Retirement Study COVID-19 Project, which were collected in June 2020 (N = 1,717). A competitive mediation model was specified within which the associations between race–ethnicity categories and depressive symptoms were mediated by infection threat, family activity disruption, economic impact, and psychological resilience. A list of pre-COVID covariates and pre-COVID depressive symptoms were adjusted for in this model.ResultsInfection threat, family activity disruption, economic impact, and psychological resilience were all higher among non-Hispanic Blacks and Hispanics than among non-Hispanic Whites. Economic impact had a positive whereas psychological resilience had a negative direct effect on depressive symptoms net of pre-COVID covariates and pre-COVID depressive symptoms. Mediation analyses revealed that, compared to non-Hispanic Whites, non-Hispanic Blacks and Hispanics had higher depressive symptoms due to their higher family activity disruption and higher economic impact, but their higher levels of psychological resilience also reduced depressive symptoms. The counteracting indirect effects offset each other, resulting in a null total effect of race–ethnicity on depressive symptoms.Discussion and ImplicationsThese findings suggest that interventions addressing the mental health impact of COVID should consider race/ethnicity-specific vulnerabilities and resilience. Future studies need to consider the complex and potentially counterbalancing mechanisms linking race–ethnicity and mental health.
Gender Biases and Diagnostic Delay in Inflammatory Bowel Disease: Multicenter Observational Study
Authors: Sempere Laura , Bernabeu Purificación , Cameo José , Gutiérrez Ana , García María Gloria , García Mariana Fe , Aguas Mariam , Belén Olivia , Zapater Pedro , Jover Rodrigo , van-der Hofstadt Carlos , Ruiz-Cantero María Teresa 
Published: January 2023

Abstract

Background
Female gender could be a cause of diagnostic delay in inflammatory bowel disease (IBD). The aim of this study was to investigate the diagnostic delay in women vs men and potential causes.

Methods
This multicenter cohort study included 190 patients with recent diagnosis of IBD (disease duration &lt;7 months). Reconstruction of the clinical presentation and diagnostic process was carried out in conjunction with the semistructured patient interview, review, and electronic medical records.

Results
The median time from symptom onset to IBD diagnosis was longer in women than in men: 12.6 (interquartile range, 3.7-31) vs 4.5 (2.2-9.8) months for Crohn’s disease (CD; P = .008) and 6.1 (3-11.2) vs 2.7 (1.5-5.6) months for ulcerative colitis (UC; P = .008). Sex was an independent variable related to the time to IBD diagnosis in Cox regression analysis. The clinical presentation of IBD was similar in both sexes. Women had a higher percentage of misdiagnosis than men (CD, odds ratio [OR], 3.9; 95% confidence [CI], 1.5-9.9; UC, OR 3.0; 95% CI, 1.2-7.4). Gender inequities in misdiagnosis were found at all levels of the health system (emergency department, OR 2.4; 95% CI, 1.1-5.1; primary care, OR 2.5; 95% CI, 1.3-4.7; gastroenterology secondary care, OR 3.2; 95% CI, 1.2-8.4; and hospital admission, OR 4.3; 95% CI, 1.1-16.9).

Conclusions
There is a longer diagnostic delay in women than in men for both CD and UC due to a drawn-out evaluation of women, with a higher number of misdiagnoses at all levels of the health care system.
Granuloma Presence at Initial Surgery Predicts Need for Repeat Surgery Independent of Rutgeerts Score in Crohn’s Disease
Authors: Ertem Furkan U , Rivers Claudia Ramos , Watson Andrew R , Tang Gong , Schwartz Marc , Johnston Elyse , Barrie Arthur , Harrison Janet , Dueker Jeffrey M , Hartman Doug , Binion David G 
Published: February 2023

Abstract

Background
Approximately half of Crohn’s disease (CD) patients experience recurrence and need for repeat resections, highlighting need for prognostic biomarkers. Presence of epithelioid granuloma on surgical tissue and high Rutgeerts endoscopic score are associated with postoperative CD clinical recurrence. We sought to evaluate presence of epithelioid granuloma at first surgery and Rutgeerts score as a combined risk assessment for CD surgical recurrence.

Methods
Our study included consented CD patients who underwent initial ileocecal resection and were prospectively followed postoperatively. From 2009 to 2019, 418 CD patients underwent initial ileocecal resection with &gt;4 years of follow-up, including postoperative endoscopic assessment (Rutgeerts score).

Results
Postoperative CD patients were grouped based on granuloma presence (30.6%; n = 128) or absence (69.4%; n = 290). Endoscopic recurrence (defined as Rutgeerts score ≥i2) was similar between the granuloma (26%) and no granuloma (25%) groups, respectively (P = .82). Patients with granuloma and CD endoscopic recurrence at first postoperative endoscopy had higher number of bowel surgeries compared with all other groups (no granuloma or CD endoscopic recurrence, P = .007; no granuloma but CD endoscopic recurrence present, P = .04; granuloma present and no CD endoscopic recurrence, P = .04). Epithelioid granuloma presence was associated with 1.65 times higher risk of subsequent surgery independently from first postoperative endoscopic recurrence Rutgeerts score.

Conclusions
Granuloma presence on initial surgical histology is immediately available and identifies high-risk CD patients who may benefit from early postoperative treatment, and these precision intervention trials are warranted.
RNA sequencing indicates widespread conservation of circadian clocks in marine zooplankton
Authors: Raghavan Venket , Eichele Gregor , Larink Otto , Karin Eli Levy , Söding Johannes 
Published: January 2023

AbstractZooplankton are important eukaryotic constituents of marine ecosystems characterized by limited motility in the water. These metazoans predominantly occupy intermediate trophic levels and energetically link primary producers to higher trophic levels. Through processes including diel vertical migration (DVM) and production of sinking pellets they also contribute to the biological carbon pump which regulates atmospheric CO2 levels. Despite their prominent role in marine ecosystems, and perhaps, because of their staggering diversity, much remains to be discovered about zooplankton biology. In particular, the circadian clock, which is known to affect important processes such as DVM has been characterized only in a handful of zooplankton species. We present annotated de novo assembled transcriptomes from a diverse, representative cohort of 17 marine zooplankton representing six phyla and eight classes. These transcriptomes represent the first sequencing data for a number of these species. Subsequently, using translated proteomes derived from this data, we demonstrate in silico the presence of orthologs to most core circadian clock proteins from model metazoans in all sequenced species. Our findings, bolstered by sequence searches against publicly available data, indicate that the molecular machinery underpinning endogenous circadian clocks is widespread and potentially well conserved across marine zooplankton taxa.
ARBic: an all-round biclustering algorithm for analyzing gene expression data
Authors: Liu Xiangyu , Yu Ting , Zhao Xiaoyu , Long Chaoyi , Han Renmin , Su Zhengchang , Li Guojun 
Published: January 2023

Abstract
Identifying significant biclusters of genes with specific expression patterns is an effective approach to reveal functionally correlated genes in gene expression data. However, none of existing algorithms can simultaneously identify both broader and narrower biclusters due to their failure of balancing between effectiveness and efficiency. We introduced ARBic, an algorithm which is capable of accurately identifying any significant biclusters of any shape, including broader, narrower and square, in any large scale gene expression dataset. ARBic was designed by integrating column-based and row-based strategies into a single biclustering procedure. The column-based strategy borrowed from RecBic, a recently published biclustering tool, extracts narrower biclusters, while the row-based strategy that iteratively finds the longest path in a specific directed graph, extracts broader ones. Being tested and compared to other seven salient biclustering algorithms on simulated datasets, ARBic achieves at least an average of 29% higher recovery, relevance and$\ {F}_1$ scores than the best existing tool. In addition, ARBic substantially outperforms all tools on real datasets and is more robust to noises, bicluster shapes and dataset types.
Importance of Long-Term Shallow Degassing of Basaltic Magma on the Genesis of Massive Felsic Magma Reservoirs: a Case Study of Aso Caldera, Kyushu, Japan
Authors: Miyagi Isoji , Hoshizumi Hideo , Suda Taichi , Saito Genji , Miyabuchi Yasuo , Geshi Nobuo 
Published: January 2023

AbstractThis paper presents the chemical composition (including H2O and CO2) of matrix glass, melt inclusions in phenocrysts, and their host minerals in eruptive products from Aso caldera. We found a group of melt inclusions with clearly lower potassium (0.6–2 wt % K2O at 50–70 wt % SiO2) than previously reported high-K2O whole-rock compositions (3–5 wt % K2O at 55–70 wt % SiO2). While most of the high-K2O intermediate to felsic melt inclusions are vapor undersaturated and show the features of H2O, CO2, and K2O accumulation, the low-K2O basaltic melt already has higher H2O and CO2. We reconcile this discrepancy with a model in which (1) the volatile-rich basalt magmas degas near the surface, (2) migrate back to depths of $\ge$12 km in the crust, and (3) crystallize feldspar and quartz to produce high-K2O felsic melt, (4) magma mixing among the undegassed, degassed, and evolved magmas. By crystallization, about five times as much low-K2O basaltic magma is required to produce high-K2O felsic magma. The quantity of felsic magma ejected from 270 ka (Aso-1) to 90 ka (Aso-4) requires a basalt magma supply rate of 18 to 31 km3/ka. This magma supply rate is comparable to or less than the present-day production rate of degassed magma (73 km3/ka) at an active center of Aso, Nakadake. These findings suggest volcanic gas flux monitoring has the potential to be a ‘basalt usage meter’ during the dormant period of caldera volcanoes.
Does Social Desirability Bias Distort Survey Analyses of Ideology and Self-Interest? Evidence from a List Experiment on Progressive Taxation
Authors: Heide-Jørgensen Tobias 
Published: January 2023

AbstractThe relative importance of ideological orientations and material self-interest as determinants of political attitudes is still discussed. Using a novel list experiment on opposition to progressive taxation embedded in a large representative Danish online survey (N = 2,010), I study how social desirability concerns bias the conclusions survey researchers draw regarding the influence of self-interest (gauged by income) and ideology (measured by left-right self-identifications) on public opinion. I find that right-wingers are much less opposed to progressive taxation when attitudes are measured indirectly and unobtrusively by means of the list experiment relative to asking directly about their opinions. In fact, rightists are no more against progressive taxation than leftists and centrists. Furthermore, opposition to tax progressivity is considerably lower among low-income individuals when social desirability bias is addressed, thereby increasing the attitudinal gap between low- and high-income individuals. The implications of the findings are that survey research risks exaggerating the importance of ideological orientations and underestimating how much political views reflect material self-interest.
AIBP regulates TRPV1 activation in chemotherapy-induced peripheral neuropathy by controlling lipid raft dynamics and proximity to TLR4 in dorsal root ganglion neurons
Authors: Navia-Pelaez Juliana M. , Borges Paes Lemes Julia , Gonzalez Leonardo , Delay Lauriane , dos Santos Aggum Capettini Luciano , Lu Jenny W. , Gonçalves Dos Santos Gilson , Gregus Ann M. , Dougherty Patrick M. , Yaksh Tony L. , Miller Yury I. 
Published: January 2023

Abstract
Nociceptive afferent signaling evoked by inflammation and nerve injury is mediated by the opening of ligand-gated and voltage-gated receptors or channels localized to cholesterol-rich lipid raft membrane domains. Dorsal root ganglion (DRG) nociceptors express high levels of toll-like receptor 4 (TLR4), which also localize to lipid rafts. Genetic deletion or pharmacologic blocking of TLR4 diminishes pain associated with chemotherapy-induced peripheral neuropathy (CIPN). In DRGs of mice with paclitaxel-induced CIPN, we analyzed DRG neuronal lipid rafts, expression of TLR4, activation of transient receptor potential cation channel subfamily V member 1 (TRPV1), and TLR4–TRPV1 interaction. Using proximity ligation assay, flow cytometry, and whole-mount DRG microscopy, we found that CIPN increased DRG neuronal lipid rafts and TLR4 expression. These effects were reversed by intrathecal injection of apolipoprotein A-I binding protein (AIBP), a protein that binds to TLR4 and specifically targets cholesterol depletion from TLR4-expressing cells. Chemotherapy-induced peripheral neuropathy increased TRPV1 phosphorylation, localization to neuronal lipid rafts, and proximity to TLR4. These effects were also reversed by AIBP treatment. Regulation of TRPV1-TLR4 interactions and their associated lipid rafts by AIBP covaried with the enduring reversal of mechanical allodynia otherwise observed in CIPN. In addition, AIBP reduced intracellular calcium in response to the TRPV1 agonist capsaicin, which was increased in DRG neurons from paclitaxel-treated mice and in the naïve mouse DRG neurons incubated in vitro with paclitaxel. Together, these results suggest that the assembly of nociceptive and inflammatory receptors in the environment of lipid rafts regulates nociceptive signaling in DRG neurons and that AIBP can control lipid raft–associated nociceptive processing.