bluuebunny/crossref_metadata_2025_split huggingface dataset:
The hypoxic ventilatory response and hypoxic burden are predictors of the magnitude of ventilatory long‐term facilitation in humans
Authors: Panza Gino S. , Kissane Dylan M. , Puri Shipra , Mateika Jason H. 
Published: August 2023

AbstractMild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long‐term facilitation (vLTF) in humans. The magnitude of these forms of plasticity might be influenced by anthropometric and physiological variables, as well as protocol elements. However, the impact of many of these variables on the magnitude of respiratory plasticity has not been established in humans. A meta‐analysis was completed using anthropometric and physiological variables obtained from 124 participants that completed one of three intermittent hypoxia protocols. Simple correlations between the aggregate variables and the magnitude of PA and vLTF standardized to baseline was completed. Thereafter, the variables correlated to PA or vLTF were input into a multilinear regression equation. Baseline measures of the hypoxic ventilatory response was the sole predictor of PA (R = 0.370, P = 0.012). Similarly, this variable along with the hypoxic burden predicted the magnitude of vLTF (R = 0.546, P < 0.006 for both variables). In addition, the magnitude of PA was strongly correlated to vLTF (R = 0.617, P < 0.001). Anthropometric measures do not predict the magnitude of PA and vLTF in humans. Alternatively, the hypoxic ventilatory response was the sole predictor of PA, and in combination with the hypoxic burden, predicted the magnitude of vLTF. These influences should be considered in the design of mild intermittent hypoxia protocol studies in humans. Moreover, the strong correlation between PA and vLTF suggests that a common mechanistic pathway may have a role in the initiation of these forms of plasticity.
imageKey points
Mild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long‐term facilitation (vLTF) in humans.
Many of the anthropometric and physiological variables that could impact the magnitude of these forms of plasticity are unknown.
Anthropometric and physiological variables were measured from a total of 124 participants that completed one of three distinct intermittent hypoxia protocols. The variables correlated to PA or vLTF were input into a multilinear regression analysis.
The hypoxic ventilatory response was the sole predictor of PA, while this variable in addition to the average hypoxic burden predicted the magnitude of vLTF. A strong correlation between PA and vLTF was also revealed.
These influences should be considered in the design of mild intermittent hypoxia protocol studies in humans. Moreover, the strong correlation between PA and vLTF suggests that a common mechanistic pathway may have a role in the initiation of these forms of plasticity.
Analysis and Validation of a Flexible Limb/Cable Hybrid-Driven Parallel Continuum Manipulator
Authors: Kang Yezheng , Liang Zhenkun , Yan Tianyi , Duan Xuyang , Wang Hao , Seidelmann Joachim , Chen Genliang 
Published: August 2023

Abstract
Cable-driven parallel manipulators and parallel continuum manipulators have attracted increasing attention in pick-and-place manipulation, owing to their low inertia and high safety. In cable-driven parallel robots, cables are utilized to control a moving platform, whereas parallel continuum manipulators employ flexible limbs. By combing these two types of mechanisms, the authors propose a novel flexible limb/cable hybrid-driven parallel continuum manipulator (HDPCM). The flexible limbs, equipped with their ability to withstand pushing forces applied on the moving platform, are a critical component of the HDPCM. Meanwhile, the cables, with their proficiency to modulate the shape of the flexible limbs and endure some of the pulling force, reduce the possibility of large divergence in flexible limbs. This results in an improved reachable workspace and load capacity for the manipulator. To predict the configuration of the proposed manipulator, an efficient kinetostatics analysis is given, utilizing a discretization-based approach. Among the infinitely many solutions to the inverse problem, the configuration with minimal potential energy is selected as the optimal solution. Finally, a prototype is fabricated, and validation experiments are conducted, which demonstrate that the prototype exhibits acceptable positioning accuracy and passive compliance. Furthermore, the proposed manipulator is validated to possess relatively superior performance in the workspace and load capacity.
Sas3-mediated histone acetylation regulates effector gene activation in a fungal plant pathogen
Authors: Suarez-Fernandez Marta , Álvarez-Aragón Rocio , Pastor-Mediavilla Ana , Maestre-Guillén Alejandro , del Olmo Ivan , De Francesco Agustina , Meile Lukas , Sánchez-Vallet Andrea 
Published: August 2023

ABSTRACT

Effector proteins are secreted by plant pathogens to enable host colonization. Typically, effector genes are tightly regulated, have very low expression levels in axenic conditions, and are strongly induced during host colonization. Chromatin remodeling contributes to the activation of effector genes
in planta
by still poorly known mechanisms. In this work, we investigated the role of histone acetylation in effector gene derepression in plant pathogens. We used
Zymoseptoria tritici
, a major pathogen of wheat, as a model to determine the role of lysine acetyltransferases (KATs) in plant infection. We showed that effector gene activation is associated with chromatin remodeling, featuring increased acetylation levels of histone H3 lysine 9 (H3K9) and 14 (H3K14) in effector loci. We functionally characterized the role of
Z. tritici
KATs and demonstrated their distinct contributions to growth, development, and infection. Sas3 is required for host colonization and pycnidia production and is involved in the acetylation of H3K9 and H3K14 in effector loci and, consequently, in effector gene activation during plant infection. We propose that Sas3-mediated histone acetylation is required for the spatiotemporal activation of effector genes and the virulence of
Z. tritici
.

IMPORTANCE

Pathogen infections require the production of effectors that enable host colonization. Effectors have diverse functions and are only expressed at certain stages of the infection cycle. Thus, effector genes are tightly regulated by several mechanisms, including chromatin remodeling. Here, we investigate the role of histone acetylation in effector gene activation in the fungal wheat pathogen
Zymoseptoria tritici
. We demonstrate that lysine acetyltransferases (KATs) are essential for the spatiotemporal regulation of effector genes. We show that the KAT Sas3 is involved in leaf symptom development and pycnidia formation. Importantly, our results indicate that Sas3 controls histone acetylation of effector loci and is a regulator of effector gene activation during stomatal penetration. Overall, our work demonstrates the key role of histone acetylation in regulating gene expression associated with plant infection.
The Oldest Trace Fossils in Association with an Ediacara-Type Biota in the Upper Vendian of the South Urals
Authors: Kolesnikov A. V. , Desyatkin V. D. , Terekhova V. A. , Pan’kov V. N. , Maslov A. V. 
Published: August 2023

Abstract
Trace fossils and palaeopascichnids have been studied in the Basa Formation of the Vendian Asha Group of the South Urals (southwestern periphery of the Suleiman Anticline, Shubino quarry in Ust’-Katav, Chelyabinsk Region of Russia). The general morphology and preservation of ichnofossils have been shown to be similar to the Late Vendian–Early Cambrian subhorizontal bilobate burrows of Didymaulichnus. The paleontological remains have been found to be confined to extremely shallow deposition settings and located stratigraphically below the volcanic tuff layer with a zircon U–Pb isotopic age of 578 ± 7 Ma. Until now, the first occurrence of ichnofossils and the associated “Agronomic Revolution” were dated at ~560–550 Ma. According to our study results, mobile benthos and biological mixing of sediments could have occurred 20–30 Ma earlier. The hypothesis that the onset of the “First Agronomic Revolution” and the “Cambrian Explosion” were far from being close in time was confirmed.
Application of algorithmic cytomorphological assessment and immunocytochemistry with the international system for reporting serous fluid cytopathology on pericardial fluid cytology
Authors: Li Joshua J X , Cheung Wing , Ng Joanna K M , Tse Gary M 
Published: August 2023

AimsThe international system for reporting serous fluid cytopathology (ISRSFC) set forth a five-tiered reporting system with comprehensive validation on pleural and peritoneal fluid cytology. An algorithmic approach for cytomorphological assessment and immunocytochemistry was also described in ISRSFC. Limited data on pericardial fluid are supportive but would benefit from further investigation.MethodsConsecutive pericardial fluid cytology over a 4-year period was reviewed by multiple board-certified pathologists according to the ISRSFC. Cytomorphology and immunocytochemistry were assessed sequentially, with respective diagnostic performances computed and compared. Literature review was performed.ResultsIn total 358 specimens, including 53 with immunocytochemistry available, were reviewed. There were 137 benign and 221 malignant (MAL) cases. The risks of malignancy were 23.5% non-diagnostic (ND), 29.2% negative for malignancy (NFM), 56.0% atypia of undetermined significance (AUS), 82.6% suspicious for malignancy (SFM) and 99.2% (MAL) for cytomorphological assessment, improving to 23.5% (ND), 29.1% (NFM), 56.8% (AUS), 78.9% (SFM) and 99.3% (MAL) incorporating immunocytochemistry. Ten cases (2.8%) received a change in diagnosis after review of immunocytochemistry. All revisions of diagnostic category were appropriate upgrades/downgrades referenced against clinical information. Cytomorphological typing was accurate for adenocarcinoma (n=81/83, 97.6%), while other carcinomas and lymphomas required immunocytochemistry. Certain subcategories within AUS and SFM pertaining to bland indeterminate epithelial cells or mucinous material were not seen for pericardial fluid.ConclusionsThe ISRSFC shows robust diagnostic performance for pericardial fluid cytology. For pericardial effusion, disease composition and applicable cytological subcategories differ from its peritoneal and pleural counterparts. Incorporating immunocytochemistry by an algorithmic approach improves diagnostic accuracy. Cytomorphology is accurate for identifying adenocarcinomas, but further typing necessitates immunocytochemistry is necessary.
Monitoring website marketing among leading e-cigarette brands and vendors in California: content analysis
Authors: Donaldson Scott I , Beard Trista , Dormanesh Allison , Pérez Cindy , Escobedo Patricia , Unger Jennifer B , Wipfli Heather Lynn , Galimov Artur , Allem Jon-Patrick 
Published: August 2023

BackgroundElectronic cigarette (e-cigarette) brands and vendors use websites to promote pro-tobacco messages that may increase susceptibility to use e-cigarettes among never users or help sustain continued e-cigarette use among current users. E-cigarette website marketing is lightly regulated, and little is known about promotional strategies used on e-cigarette companies’ websites. This study conducted a content analysis of website marketing from leading e-cigarette companies selling products in California.MethodsThis study identified 20 e-cigarette vendors and 6 e-cigarette brands that had products available for purchase online in California. Two coders visited 26 websites between 06 February 2022 and 17 April 2022. Websites were coded for marketing themes, promotional and interactive content, availability of flavoured e-cigarette products, presence of health warnings, and reference to tobacco control policies.ResultsMarketing themes related to physical health benefits of e-cigarette use were found on 50.0% of the websites. 57.7% of the websites had sales/discounts/coupons. 65.4% of the websites had fruit-flavoured disposable e-cigarettes, while 73.1% of the websites had fruit-flavoured e-liquids available for purchase. 69.2% of the websites allowed users to sign up for email newsletters, and 88.9% of such websites did not require users to create an age-verified account to receive email newsletters.ConclusionsFindings from this study can be used to inform statewide regulations of promotional communications found on e-cigarette companies’ websites and encourage enforcement of age-verification procedures. This may help reduce susceptibility to use, or continued use of, e-cigarette products among price-sensitive populations, such as adolescents and young adults.
Amplitude-assisted tagging of longitudinally polarised bosons using wide neural networks
Authors: Grossi Michele , Incudini Massimiliano , Pellen Mathieu , Pelliccioli Giovanni 
Published: August 2023

AbstractExtracting longitudinal modes of weak bosons in LHC processes is essential to understand the electroweak-symmetry-breaking mechanism. To that end, we propose a general method, based on wide neural networks, to properly model longitudinal-boson signals and hence enable the event-by-event tagging of longitudinal bosons. It combines experimentally accessible kinematic information and genuine theoretical inputs provided by amplitudes in perturbation theory. As an application we consider the production of a Z boson in association with a jet at the LHC, both at leading order and in the presence of parton-shower effects. The devised neural networks are able to extract reliably the longitudinal contribution to the unpolarised process. The proposed method is very general and can be systematically extended to other processes and problems.
A Phase II Trial of Rivoceranib, an Oral Vascular Endothelial Growth Factor Receptor 2 Inhibitor, for Recurrent or Metastatic Adenoid Cystic Carcinoma
Authors: Hanna Glenn J. , Ahn Myung-Ju , Muzaffar Jameel , Keam Bhumsuk , Bowles Daniel W. , Wong Deborah J. , Ho Alan L. , Kim Sung-Bae , Worden Francis , Yun Tak , Meng Xianzhang , Van Tornout Jan M. , Conlan Maureen G. , Kang Hyunseok 
Published: August 2023

Abstract

Purpose:
This open-label, single-arm, phase II study evaluated the vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase inhibitor (TKI) rivoceranib in patients with recurrent or metastatic (R/M) adenoid cystic carcinoma (ACC).

Patients and Methods:
Eligible patients had confirmed disease progression per Response Evaluation Criteria in Solid Tumors (RECIST) with ≥20% increase in radiologically or clinically measurable lesions or appearance of new lesions within the preceding 6 months. Patients received oral rivoceranib 700 mg once daily. Primary outcomes were objective response rate (ORR) by investigator review and by blinded independent review committee (BIRC).

Results:
Eighty patients were enrolled and 72 were efficacy evaluable. Seventy-four patients had distant metastases and 49 received prior systemic treatment (14 received VEGFR TKIs). Per investigator and BIRC, respectively, ORR was 15.3% [95% confidence interval (95% CI), 7.9–25.7] and 9.7% (95% CI, 4.0–19.0); median duration of response was 14.9 months (95% CI, 4.9–17.3) and 7.2 months (95% CI, 3.5–8.4); and median progression-free survival was 9.0 months (95% CI, 7.3–11.5) and 9.0 months (95% CI, 7.7–11.5). Grade ≥3 treatment-related adverse events occurred in 56 patients (70.0%); the most common were hypertension (34, 42.5%) and stomatitis (6, 7.5%). Four grade 5 events occurred with one attributed to rivoceranib (epistaxis). Sixty-eight patients (85.0%) had ≥1 dose modifications and 16 patients (20.0%) discontinued rivoceranib for toxicity.

Conclusions:
In patients with progressing R/M ACC, rivoceranib demonstrated antitumor activity and a manageable safety profile consistent with other VEGFR TKIs.
Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment and Dementia
Authors: Sawyer Russell P. , Worrall Bradford B. , Howard Virginia J. , Crowe Michael G. , Howard George , Hyacinth Hyacinth I. 
Published: August 2023

Background
Non‐Hispanic Black adults have a higher proportion of vascular cognitive impairment and Alzheimer's disease and related dementias compared with non‐Hispanic White adults that may be due to differences in the burden of cerebral small vessel disease and risk alleles for Alzheimer's disease and related dementias. We describe here the methods of an ancillary study to the REGARDS (Reason for Geographic and and Racial Difference in Stroke) study, which will examine the role of magnetic resonance imaging markers of cerebral small vessel disease and vascular as well as genetic risk factors for Alzheimer's disease and related dementias in racial disparity in the prevalence and trajectory of vascular cognitive impairment and dementia in non‐Hispanic White and non‐Hispanic Black participants.

Methods

In participants with no prior history of stroke who had an incident stroke or transient ischemic attack after enrollment in the study, magnetic resonance imaging scans will be evaluated using the Standards for Reporting Vascular Changes on Neuroimaging international consensus criteria and automated analysis pipelines for quantification of cerebral small vessel disease. Participants will be genotyped for
APOE
ε4 and
TREM2
risk alleles for Alzheimer's disease and related dementias. The 6‐item screener will define global cognitive function and be the primary cognitive outcome.

Conclusions

With at least 426 non‐Hispanic Black and 463 non‐Hispanic White participants who have at least 2 prior and 2 poststroke or transient ischemic attack cognitive assessments, we will have at least 80% power to detect a minimum effect size of 0.09 SD change in
Z
score, with correction for as many as 20 tests (ie, at
P
<0.0025, after adjusting for up to 20 covariates) for cognitive decline.
Social Justice Challenges of “Teaching”
Languages
Authors: Valdés Guadalupe 
Published: August 2023

Abstract
This essay explores the challenges to linguistic justice resulting from widely held negative perspectives on the English of young Latinx bi/multilinguals and from common misunderstandings of individuals who use resources from two communicative systems in their everyday lives. I highlight the effects of these misunderstandings on Long-Term English Learners as they engage with the formal teaching of English. I specifically problematize language instruction as it takes place in classrooms and the impact of the curricularization of language as it is experienced by minoritized students who “study” language qua language in instructed settings.
Rethinking Language Barriers & Social Justice from a
Raciolinguistic Perspective
Authors: Rosa Jonathan , Flores Nelson 
Published: August 2023

Abstract
The trope of language barriers and the toppling thereof is widely resonant as a reference point for societal progress. Central to this trope is a misleading debate between advocates of linguistic assimilation and pluralism, both sides of which deceptively normalize dominant power structures by approaching language as an isolated site of remediation. In this essay, we invite a reconsideration of how particular populations and language practices are persistently marked, surveilled, and managed. We show how perceptions of linguistic diversity become sites for the reproduction of marginalization and exclusion, as well as how advocacy for language and social justice must move beyond celebrating linguistic diversity or remediating it. We argue that by interrogating the colonial and imperial underpinnings of widespread ideas about linguistic diversity, we can connect linguistic advocacy to broader political struggles. We suggest that language and social justice efforts must link affirmations of linguistic diversity to demands for the creation of societal structures that sustain collective well-being.
Identifying Alphabetic Compositions in the Hebrew Bible
Authors: Justiss Joseph L. 
Published: August 2023

Abstract
Alphabetic acrostics (AA s) are a known phenomenon in the Hebrew Bible (HB). Recently, scholars have argued that other poems in the HB evidence “alphabetic thinking”, or some kind of consciousness of alphabet in their composition. Peter C. W. Ho has argued for what he calls alphabetic compositions (AC s), i.e., poems that are not proper acrostics but share common poetic devices with acrostics. In this article, I attempt to refine Ho’s list of common features of AA s and regroup them into macro-level and micro-level alphabet-imitating devices. With a clear understanding of these devices I test whether certain poems attempt to imitate the alphabet in their overall shape at macro-level as well as in their choice of words at micro-level. I argue that only when clear alphabet-imitating devices are present in both the form and the linguistic content of a poem can it be reliably identified as an AC. Finally, I problematize the use of AC s as a set of cross-referring poems designed to carry Psalter motifs by dealing with the possible presence of reworked and repurposed alphabetic poems in the Psalter.
Der Eigentumserwerb durch traditio
Authors: Kleňová Veronika 
Published: August 2023

Summary
The acquisition of property by traditio, In addition, putative iusta causa traditionis and consequences for the doctrine of condictio. – The Justinian Digest contain a number of texts in which the traditio transfers ownership, although the ‘causa’ on account of which the delivery takes place, does not exist in fact. The paper attempts to show that this phenomenon cannot be explained through a broad acceptance of the putative causa traditionis, because the Roman concept of the traditio ex iusta causa differed from that of the ‘titulus-modus-doctrine’. The classical Roman law considered the iusta causa in most cases as the purpose of the delivery, for which the traditio was a means to achieve; the (non-)achievement of the intended purpose did not decide on the transfer of ownership, but only whether the recovery of the performance (condictio) was admissible. This shows the way Roman law favored the transfer of ownership.
« Aussy avant les filz que les filles, et les filles que les filz » : les droits successoraux des filles de famille dans la coutume de Liège et dans les actes de la pratique du xvie siècle
Authors: Silan Marie-Sophie 
Published: August 2023

Summary
« Aussy avant les filz que les filles, et les filles que les filz » : inheritance rights of daughters according to the custom of Liège and in deeds of the 17th century. – In the 16th century, the customary law of Liège, a middle-sized estate of the Holy Roman Empire governed by a prince-bishop, excluded daughters from inheriting censal property located outside the ‘franchise’ of the states’ cities. However, such property – lands and buildings subjected to cens and annuities (‘cens’ and ‘rentes’) – often constituted a significant part of the parental estate. Aware of the issue, and of the risks that the law might lead to situations of conflicts, including legal proceedings, between their children, many parents, together or separately, derogated from the customary rule in their will. An aspect which has more rarely been brought to the fore by legal scholarship, marriage contracts were also a means to divide the inheritance equally among children.