bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacognostic standardization and machine learning–based investigations on Akebia quinata and Akebia trifoliata
Authors: Qiu Junjie , Shi Menglin , Shi Senlin , Wu Suxiang 
Published: July 2023

AbstractCurrently, Akebiae Caulis is being used in clinical practice, but there are few reseaches on its different varieties. To ensure the accuracy and effectiveness of clinical practice, this study distinguished the Akebia quinata (Thunb.) Decne. and Akebia trifoliata (Thunb.) Koidz, using organoleptic evaluation, microscopic observation, fluorescence reaction, physicochemical properties, thin‐layer chromatography, IR spectroscopy, HPLC, four machine learning models, and in vitro antioxidant methods. Analysis of the powders of these two varieties using optical microscopy revealed the presence of starch granules, cork cells, crystal fibers, scalariform vessels, and wood fibers. Scanning electron microscopy revealed the presence of scalariform vessels, pitted vessels, wood fibers, and calcium oxalate crystals. Several tissues, including the cork layer, fiber population, cortex, phloem, pith, xylem, and ray, were found in the transverse section. In addition, thin‐layer chromatography was used to identify two components: oleanolic acid and calceolarioside B; 11 common peaks were identified in 15 batches of SAQ and 5 batches of SAT by using HPLC. Support vector machine, BP neural networks, and GA‐bp neural networks were able to predict 100% accurately of the different origins of stem of Akebia quinate (Thunb.) Decne (SAQ) and Akebia trifoliata (Thunb.) Koidz (SAT). Extreme learning machine achieved a correct rate of 87.5%. Meanwhile, Fourier‐transform infrared spectroscopy fingerprint identified nine characteristic absorption peaks of the secondary metabolites of SAQ and SAT. 2,2‐Diphenyl‐1‐1‐picrylhydrazyl experiment revealed that the IC50 values of SAQ and SAT extracts were 155.49 and 128.75 μg/ml, respectively. For the 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) assay, the IC50 value of SAT extract was found to be 269.24 μg/ml, which was lower than that of SAQ extract (IC50 = 358.99 μg/ml). This study successfully used different methods to differentiate between A. quinata (Thunb.) Decne. and A. trifoliata (Thunb.) Koidz., to help decide on which type to use for clinical application.
Believing in change: The role of implicit theory on consumer's perception of the brand's corporate social responsibility message
Authors: Kim Terry Haekyung , Kim Naeun Lauren 
Published: July 2023

AbstractWith the sustainable consumption paradigms, corporate social responsibilities (CSR) across industries have been under scrutiny. However, little research exists on how brand's business model and consumers' characteristics are intertwined to influence CSR evaluation. Our study aims to examine how the brand type (e.g., fast vs. slow business model) influences the relationships among CSR‐brand fit, authenticity, and skepticism, thus improving attitudes toward the brand. In addition, based on the implicit theory, how the consumer's incremental mindset (vs. entity) influences a brand's CSR evaluations are studied. Through two studies, our findings demonstrate consumers perceived a higher CSR‐brand fit for the slow fashion/food brand than the fast fashion/food brand. A higher CSR‐brand fit heightened the CSR authenticity and alleviated skepticism, which in turn resulted in positive brand evaluations. Importantly, incremental mindsets weakened the effect of brand type on CSR‐brand fit. As one of the first studies to examine the relationship between consumers' implicit theory orientation and a brand's CSR message, our findings demonstrate that an incremental mindset is a powerful consumer characteristic in evaluating a brand's CSR activities that are less congruent with the brand's established business model.
Improving access to transcatheter aortic valve implantation across Europe by restructuring cardiovascular services: An expert council consensus statement
Authors: Zamorano José Luis , Appleby Clare , Benamer Hakim , Frankenstein Lutz , Musumeci Giuseppe , Nombela‐Franco Luis 
Published: July 2023

AbstractTranscatheter aortic valve implantation (TAVI) is recommended for a growing range of patients with severe aortic stenosis in the European Society of Cardiology and European Association for Cardio‐Thoracic Surgery (ESC/EACTS) 2021 Guidelines update. However, guideline implementation programs are needed to ensure the application of clinical recommendations which will favorably influence disease outcomes. An Expert Council was convened to identify whether cardiology services across Europe are set up to address the growing needs of patients with severe aortic stenosis for increased access to TAVI by identifying the key challenges faced in growing TAVI programs and mapping associated solutions. Wide variation exists across Europe in terms of TAVI availability and capacity to deliver the increased demand for TAVI in different countries. The recommendations of this Expert Council focus on the short‐to‐medium‐term aspects where the most immediate, actionable impact can be achieved. The focus on improving procedural efficiency and optimizing the patient pathway via clinical practice and patient management demonstrates how to mitigate the current major issues of shortfall in catheterization laboratory, workforce, and bed capacity. Procedural efficiencies may be achieved through steps including streamlined patient assessment, the benchmarking of standards for minimalist procedures, standardized approaches around patient monitoring and conduction issues, and the implementation of nurse specialists and dedicated TAVI coordinators to manage organization, logistics, and early mobilization. Increased collaboration with wider stakeholders within institutions will support successful TAVI uptake and improve patient and economic outcomes. Further, increased education, collaboration, and partnership between cardiology centers will facilitate sharing of expertise and best clinical practice.
The effect of minimally invasive suturectomy with postoperative cranial remolding orthotic treatment for an infant with bilateral coronal craniosynostosis
Authors: Taheri Zahra , Babaee Taher , Mohammadi Hassan Reza , Hajiaghaei Behnam , Khani Alireza 
Published: July 2023

Key Clinical MessageMinimally invasive suturectomy has been reported to significantly decrease the economic cost of treating infants with craniosynostosis. Nonetheless, treatment should be accompanied by a cranial remolding orthosis to maintain the constant correction and reshaping of the skull throughout the infant's development.
Smoothing and differentiation of data by Tikhonov and fractional derivative tools, applied to surface‐enhanced Raman scattering (SERS) spectra of crystal violet dye
Authors: Lemes Nelson H. T. , Santos Taináh M. R. , Tavares Camila A. , Virtuoso Luciano S. , Souza Kelly A. S. , Ramalho Teodorico C. 
Published: July 2023

AbstractAll signals obtained as instrumental response of analytical apparatus are affected by noise, as in Raman spectroscopy. Whereas Raman scattering is an inherently weak process, the noise background may lead to misinterpretations. Although surface amplification of the Raman signal using metallic nanoparticles has been a strategy employed to partially solve the signal‐to‐noise problem, the preprocessing of Raman spectral data through the use of mathematical filters has become an integral part of Raman spectroscopy analysis. In this paper, a Tikhonov modified method to remove random noise in experimental data is presented. In order to refine and improve the Tikhonov method as a filter, the proposed method includes Euclidean norm of the fractional‐order derivative of the solution as an additional criterion in Tikhonov function. In the strategy used here, the solution depends on the regularization parameter,
, and on the fractional derivative order,
. As will be demonstrated, with the algorithm presented here, it is possible to obtain a noise‐free spectrum without affecting the fidelity of the molecular signal. In this alternative, the fractional derivative works as a fine control parameter for the usual Tikhonov method. The proposed method was applied to simulated data and to surface‐enhanced Raman scattering (SERS) spectra of crystal violet dye in Ag nanoparticles colloidal dispersion.
Peptide self‐assembly as a strategy for facile immobilization of redox enzymes on carbon electrodes
Authors: Grinberg Itzhak , Ben‐Zvi Oren , Adler‐Abramovich Lihi , Yacoby Iftach 
Published: July 2023

AbstractRedox–enzyme‐mediated electrochemical processes such as hydrogen production, nitrogen fixation, and CO2 reduction are at the forefront of the green chemistry revolution. To scale up, the inefficient two‐dimensional (2D) immobilization of redox enzymes on working electrodes must be replaced by an efficient dense 3D system. Fabrication of 3D electrodes was demonstrated by embedding enzymes in polymer matrices. However, several requirements, such as simple immobilization, prolonged stability, and resistance to enzyme leakage, still need to be addressed. The study presented here aims to overcome these gaps by immobilizing enzymes in a supramolecular hydrogel formed by the self‐assembly of the peptide hydrogelator fluorenylmethyloxycarbonyl‐diphenylalanine. Harnessing the self‐assembly process avoids the need for tedious and potentially harmful chemistry, allowing the rapid loading of enzymes on a 3D electrode under mild conditions. Using the [FeFe] hydrogenase enzyme, high enzyme loads, prolonged resistance against electrophoresis, and highly efficient hydrogen production are demonstrated. Further, this enzyme retention is shown to arise from its interaction with the peptide nanofibrils. Finally, this method is successfully used to retain other redox enzymes, paving the way for a variety of enzyme‐mediated electrochemical applications.
Three Oxidative Addition Routes of Alkali Metal Aluminyls to Dihydridoaluminates and Reactivity with CO2
Authors: Banerjee Sumanta , Ballmann Gerd M. , Evans Matthew J. , O'Reilly Andrea , Kennedy Alan R. , Fulton J. Robin , Coles Martyn P. , Mulvey Robert E. 
Published: July 2023

AbstractThree distinct routes are reported to the soluble, dihydridoaluminate compounds, AM[Al(NONDipp)(H)2] (AM=Li, Na, K, Rb, Cs; [NONDipp]2−=[O(SiMe2NDipp)2]2−; Dipp=2,6‐iPr2C6H3) starting from the alkali metal aluminyls, AM[Al(NONDipp)]. Direct H2 hydrogenation of the heavier analogues (AM=Rb, Cs) produced the first examples of structurally characterized rubidium and caesium dihydridoaluminates, although harsh conditions were required for complete conversion. Using 1,4‐cyclohexadiene (1,4‐CHD) as an alternative hydrogen source in transfer hydrogenation reactions provided a lower energy pathway to the full series of products for AM=Li−Cs. A further moderation in conditions was noted for the thermal decomposition of the (silyl)(hydrido)aluminates, AM[Al(NONDipp)(H)(SiH2Ph)]. Probing the reaction of Cs[Al(NONDipp)] with 1,4‐CHD provided access to a novel inverse sandwich complex, [{Cs(Et2O)}2{Al(NONDipp)(H)}2(C6H6)], containing the 1,4‐dialuminated [C6H6]2− dianion and representing the first time that an intermediate in the commonly utilized oxidation process of 1,4‐CHD to benzene has been trapped. The synthetic utility of the newly installed Al−H bonds has been demonstrated by their ability to reduce CO2 under mild conditions to form the bis‐formate AM[Al(NONDipp)(O2CH)2] compounds, which exhibit a diverse series of eyecatching bimetallacyclic structures.
Sequential Water Sorption/Desorption of a Nonporous Adaptive Organic Ligand Bridged Coordination Polymer for Atmospheric Moisture Harvesting
Authors: Meng Liao , Lan Jian‐Hui , Huang Zhi‐Wei , Liu Yang , Hu Kong‐Qiu , Yuan Li‐Yong , Wang Xin‐Peng , Chai Zhi‐Fang , Mei Lei , Shi Wei‐Qun 
Published: July 2023

AbstractMoisture harvesters with favourable attributes such as easy synthetic availability and good processability as alternatives for atmospheric moisture harvesting (AWH) are desirable. This study reports a novel nonporous anionic coordination polymer (CP) of uranyl squarate with methyl viologen (MV2+) as charge balancing ions (named U‐Squ‐CP) which displays intriguing sequential water sorption/desorption behavior as the relative humidity (RH) changes gradually. The evaluation of AWH performance of U‐Squ‐CP shows that it can absorb water vapor under air atmosphere at a low RH of 20 % typical of the levels found in most dry regions of the world, and have good cycling durability, thus demonstrating the capability as a potential moisture harvester for AWH. To the authors’ knowledge, this is the first report on non‐porous organic ligand bridged CP materials for AWH. Moreover, a stepwise water‐filling mechanism for the water sorption/desorption process is deciphered by comprehensive characterizations combining single‐crystal diffraction, which provides a reasonable explanation for the special moisture harvesting behaviour of this non‐porous crystalline material.
Filtrationsmembranen und spezifische Adsorber auf der Basis von maßgeschneiderten selbst‐organiserenden Blockcopolymeren
Authors: Abetz Volker 
Published: July 2023

AbstractBlockcopolymere bieten aufgrund ihrer Fähigkeit, selbstorganisierte Strukturen zu bilden, verschiedene Möglichkeiten für die Stofftrennung. Flach‐ und Hohlfadenmembranen mit regelmäßig angeordneten Poren gleichen Durchmessers und hoher Porenzahldichte können aus selbstorganisierenden Blockcopolymeren hergestellt werden. Die Porengrößen und Funktionalitäten dieser Membranen und damit deren Einsatzmöglichkeiten in der Stofftrennung können auf verschiedenen Wegen eingestellt werden, wobei die Einstellung dieser Parameter an fertigen Membranstrukturen besonders interessant ist. Weiterhin können maßgeschneiderte amphiphile Blockcopolymere zur spezifischen Extraktion von Stoffen aus wässrigen (hydrophilen) Lösungen in organische (hydrophobe) Lösungen eingesetzt werden.
Designing a novel portable oxidation–reduction potential and microbial fuel cell‐based sensor to monitor microbial growth
Authors: Teng Peng , Lin Yen‐Han 
Published: July 2023

AbstractThis study demonstrates the potential application of a portable 3D‐printed sensor to monitor microbial growth during soil bioremediation. Bacillus subtilis, a commonly found soil microorganism, is used to evaluate its growth characteristics. The integration of real‐time oxidation–reduction potential (ORP) reading and voltage output allows for a better illustration of microbial growth, with a focus on the mid‐exponential growth phase. This new technology can potentially increase the efficiency of soil bioremediation techniques by providing a better understanding of the microbial interactions and growth patterns involved.
Structure‐Activity Relationships, Tolerability and Efficacy of Microtubule‐Active 1,2,4‐Triazolo[1,5‐a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis**
Authors: Monti Ludovica , Liu Lawrence J. , Varricchio Carmine , Lucero Bobby , Alle Thibault , Yang Wenqian , Ben‐Shalom Ido , Gilson Michael , Brunden Kurt R. , Brancale Andrea , Caffrey Conor R. , Ballatore Carlo 
Published: July 2023

AbstractTubulin and microtubules (MTs) are potential protein targets to treat parasitic infections and our previous studies have shown that the triazolopyrimidine (TPD) class of MT‐active compounds hold promise as antitrypanosomal agents. MT‐targeting TPDs include structurally related but functionally diverse congeners that interact with mammalian tubulin at either one or two distinct interfacial binding sites; namely, the seventh and vinca sites, which are found within or between α,β‐tubulin heterodimers, respectively. Evaluation of the activity of 123 TPD congeners against cultured Trypanosoma brucei enabled a robust quantitative structure‐activity relationship (QSAR) model and the prioritization of two congeners for in vivo pharmacokinetics (PK), tolerability and efficacy studies. Treatment of T. brucei‐infected mice with tolerable doses of TPDs significantly decreased blood parasitemia within 24 h. Further, two once‐weekly doses at 10 mg/kg of a candidate TPD significantly extended the survival of infected mice relative to infected animals treated with vehicle. Further optimization of dosing and/or the dosing schedule of these CNS‐active TPDs may provide alternative treatments for human African trypanosomiasis.
Photobleaching Kinetics and Effect of Solvent in the Photophysical Properties of Indocyanine Green for Photodynamic Therapy
Authors: Díaz Tovar Johan Sebastián , Kassab Giulia , Inada Natalia Mayumi , Bagnato Vanderlei Salvador , Kurachi Cristina 
Published: July 2023

AbstractIndocyanine green is an attractive molecule for photodynamic therapy due to its near infrared absorption, resulting in a higher tissue penetration. However, its quantum yields of the triplet and singlet state have been reported to be low and then, reactive oxygen species are unlikely to be formed. Aiming to understand the ICG role in photodynamic response, its photobleaching behavior in solution has been studied under distinct conditions of CW laser irradiation at 780 and 808 nm, oxygen saturations and solvents. Sensitizer bleaching and photoproduct formation were measured by absorption spectroscopy and analyzed using the PDT bleaching macroscopic model to extract physical parameters. ICG photobleaching occurs even at lower oxygen concentrations, indicating that the molecule presents more than one way of degradation. Photoproducts were produced even in solution of less than 4 % oxygen saturation for both solvents and excitation wavelengths. Also, the amplitude of absorption related to J‐dimers was increased during irradiation, but only in 50 % PBS solution. The formation of photoproducts was enhanced in the presence of J‐type dimers under low oxygen concentration, and the quantum yields of triplet and singlet states were one order of magnitude and two times higher, respectively, when compared to ICG in distilled H2O.
It’s All Hands on Deck in the Battle Against Herbicide‐Resistant Weeds
Authors: Stahl Liz , Anderson Meaghan , Nicolai Dave , Peters Tom 
Published: July 2023

AbstractWhile we know herbicide resistance is an inevitable fate in a system that relies heavily on herbicides, we can work together to focus on long‐term strategies to delay its development and spread. Managing for a single year is a key reason why we are in the situation we are in today. A review of how herbicide resistance issues developed over time provides some insight into this and also some guidance into how we can more effectively deal with the problems we face now and into the future. Farmers rely heavily on their advisers to provide sound agronomic recommendations, and we, as advisers, need to take that role seriously to broach the subject of long‐term weed management beyond individual‐year herbicide recommendations. Earn 1.5 CEUs in Integrated Pest Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
Copper‐Catalyzed Benzylic Functionalization of Lignin‐Derived Monomers
Authors: Lavrencic Lara , Dhawa Uttam , Blumenstein Arthur , Hu Xile 
Published: July 2023

AbstractWithin the field of lignin biorefining, significant research effort has been dedicated to the advancement of catalytic methods for lignocellulose depolymerization. However, another key challenge in lignin valorization is the conversion of the obtained monomers into higher value‐added products. To address this challenge, new catalytic methods that can fully embrace the inherent complexity of their target substrates are needed. Here, we describe copper‐catalyzed reactions for benzylic functionalization of lignin‐derived phenolics via intermediate formation of hexafluoroisopropoxy‐masked para‐quinone methides (p‐QMs). By controlling the rates of copper catalyst turnover and p‐QM release, we have developed copper‐catalyzed allylation and alkynylation reactions of lignin‐derived monomers to install various unsaturated fragments amenable to further synthetic applications.
The impact of biliary stents on the diagnostic yield of endoscopic ultrasound‐guided fine needle aspiration for solid pancreatic lesions: A single‐center retrospective study and meta‐analysis
Authors: Endo Go , Ishigaki Kazunaga , Hamada Tsuyoshi , Nakai Yousuke , Ishida Kota , Kurihara Kohei , Tange Shuichi , Takaoka Shinya , Tokito Yurie , Suzuki Yukari , Oyama Hiroki , Kanai Sachiko , Suzuki Tatsunori , Sato Tatsuya , Hakuta Ryunosuke , Saito Tomotaka , Takahara Naminatsu , Fujishiro Mitsuhiro 
Published: July 2023

AbstractBackgroundEndoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) is widely used for the pathological diagnosis of solid pancreatic lesions but in cases with obstructive jaundice, transpapillary sampling can be performed during endoscopic retrograde cholangiopancreatography with transpapillary biliary stent placement. Thus, it is still controversial whether EUS‐FNA should be performed prior to endoscopic retrograde cholangiopancreatography with biliary stent placement or only after negative transpapillary sampling.MethodsThe accuracy, sensitivity, and specificity of EUS‐FNA for solid pancreatic lesions with or without indwelling biliary stents were retrospectively studied in patients undergoing EUS‐FNA between January 2017 and December 2021. We also conducted a meta‐analysis including our data to compare the accuracy and sensitivity of EUS‐FNA with or without biliary stents.ResultsA total of 509 patients (40 with biliary stents and 469 without biliary stents) were included. The accuracy (77.5% vs. 94.5%, p < 0.001) and sensitivity (71.0% vs. 91.7%, p < 0.001) were lower in EUS‐FNA with biliary stents. A meta‐analysis confirmed that accuracy (odds ratio [OR] of 0.43, 95% confidence interval [CI] 0.29–0.62, p < 0.001) and sensitivity (OR of 0.46, 95% CI 0.33–0.64, p < 0.001) were lower in EUS‐FNA with biliary stents. There were no statistically significant differences between plastic stents and self‐expandable metallic stents for accuracy or sensitivity.ConclusionsThe presence of biliary stents had a negative impact on the diagnostic performance of EUS‐FNA, and EUS‐FNA prior to endoscopic retrograde cholangiopancreatography with biliary stent placement should be considered in cases with obstructive jaundice.