bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo
Authors: Magoling Bryan John Abel , Wu Anthony Yan‐Tang , Chen Yen‐Ju , Wong Wendy Wan‐Ting , Chuo Steven Ting‐Yu , Huang Hsi‐Chien , Sung Yun‐Chieh , Hsieh Hsin Tzu , Huang Poya , Lee Kang‐Zhang , Huang Kuan‐Wei , Chen Ruey‐Hwa , Chen Yunching , Lai Charles Pin‐Kuang 
Published: January 2023

AbstractExtracellular vesicles (EVs) are released by cells to mediate intercellular communication under pathological and physiological conditions. While small EVs (sEVs; <100–200 nm, exosomes) are intensely investigated, the properties and functions of medium and large EVs (big EVs (bEVs); >200 nm, microvesicles) are less well explored. Here, bEVs and sEVs are identified as distinct EV populations, and it is determined that bEVs are released in a greater bEV:sEV ratio in the aggressive human triple‐negative breast cancer (TNBC) subtype. PalmGRET, bioluminescence‐resonance‐energy‐transfer (BRET)‐based EV reporter, reveals dose‐dependent EV biodistribution at nonlethal and physiological EV dosages, as compared to lipophilic fluorescent dyes. Remarkably, the bEVs and sEVs exhibit unique biodistribution profiles, yet individually promote in vivo tumor growth in a syngeneic immunocompetent TNBC breast tumor murine model. The bEVs and sEVs share mass‐spectrometry‐identified tumor‐progression‐associated EV surface membrane proteins (tpEVSurfMEMs), which include solute carrier family 29 member 1, Cd9, and Cd44. tpEVSurfMEM depletion attenuates EV lung organotropism, alters biodistribution, and reduces protumorigenic potential. This study identifies distinct in vivo property and function of bEVs and sEVs in breast cancer, which suggest the significant role of bEVs in diseases, diagnostic and therapeutic applications.
Thermoresponsive Electrolytes for Safe Lithium‐Metal Batteries
Authors: Jiang Feng‐Ni , Cheng Xin‐Bing , Yang Shi‐Jie , Xie Jin , Yuan Hong , Liu Lei , Huang Jia‐Qi , Zhang Qiang 
Published: January 2023

AbstractExploring advanced strategies in alleviating the thermal runaway of lithium‐metal batteries (LMBs) is critically essential. Herein, a novel electrolyte system with thermoresponsive characteristics is designed to largely enhance the thermal safety of 1.0 Ah LMBs. Specifically, vinyl carbonate (VC) with azodiisobutyronitrile is introduced as a thermoresponsive solvent to boost the thermal stability of both the solid electrolyte interphase (SEI) and electrolyte. First, abundant poly(VC) is formed in SEI with thermoresponsive electrolyte, which is more thermally stable against lithium hexafluorophosphate compared to the inorganic components widely acquired in routine electrolyte. This increases the critical temperature for thermal safety (the beginning temperature of obvious self‐heating) from 71.5 to 137.4 °C. The remained VC solvents can be polymerized into poly(VC) as the battery temperature abnormally increases. The poly(VC) can not only afford as a barrier to prevent the direct contact between electrodes, but also immobilize the free liquid solvents, thereby reducing the exothermic reactions between electrodes and electrolytes. Consequently, the internal‐short‐circuit temperature and “ignition point” temperature (the starting temperature of thermal runaway) of LMBs are largely increased from 126.3 and 100.3 °C to 176.5 and 203.6 °C. This work provides novel insights for pursuing thermally stable LMBs with the addition of various thermoresponsive solvents in commercial electrolytes.
LaMgGa11O19:Cr3+,Ni2+ as Blue‐Light Excitable Near‐Infrared Luminescent Materials with Ultra‐Wide Emission and High External Quantum Efficiency
Authors: Zhang Qianqian , Liu Dongjie , Wang Zhennan , Dang Peipei , Lian Hongzhou , Li Guogang , Lin Jun 
Published: January 2023

AbstractHighly efficient luminescence material covering near‐infrared (NIR) I (700–1000 nm) and II (1000–1700 nm) is of great importance for phosphor‐converted NIR light‐emitting diodes (pc‐LEDs) light sources. The lack of ultra‐wide emission NIR luminescent materials that can be excited by cheap blue‐LEDs, suspends the applications of NIR pc‐LEDs. Ni2+‐activated phosphor usually gives an NIR‐II region emission, however, it presents low quantum efficiency due to poor absorption in blue light region. Here, a blue‐LED‐excitable (400–480 nm) LaMgGa11O19(LMG):Cr3+,Ni2+ NIR‐emitting phosphor is reported. Significantly, by constructing energy transfer from Cr3+ to Ni2+, it demonstrates an ultra‐wide NIR emission from 650 to 1600 nm, and greatly improves external quantum efficiency (EQE) from 2% to 53%. Besides, the weakened exchange coupling of Ni2+−Ni2+ pairs leads to an abnormal blue‐shift of Ni2+ emission with increasing temperature. The fabricated NIR pc‐LED gives a high output power of 8 mW at 20 mA with the photoelectric efficiency of 14%, which favors potential applications in night‐vision technology, medical applications, non‐destructive analysis, and spectroscopic analysis. This exploration of Cr3+‐Ni2+ co‐doped strategy for realizing high‐performance NIR‐emitting phosphor provides novel and effective design insights into developing more ultra‐broadband NIR pc‐LEDs based on cheap blue LEDs.
Tunable Metasurface Based on Plasmonic Quasi Bound State in the Continuum Driven by Metallic Quantum Wells
Authors: Ma Hongbin , Niu Junru , Gao Bingtao , Zhang Yiyun , Feng Yiming , Gao Fei , Chen Hongsheng , Qian Haoliang 
Published: January 2023

AbstractEffectual free‐space optical metasurface is essential for telecommunication and information processing. However, the lack of efficient optical nonlinearity is still an obstacle to empower its full capability and practical applications. Metallic quantum wells (MQWs) with large nonlinear susceptibility may pave a new way. Here, such MQWs are implemented into a resonance configuration of the quasi bound state in the continuum (BIC) and an efficient tunable plasmonic metasurface is proposed. Such metasurface is composed of MQWs‐based nanostructure, which supports the tunable plasmonic quasi‐BIC. The tunability is controlled through substantial change in refractive index of MQWs induced by Kerr‐type nonlinearity, which leads to around 9 dB extinction ratio and extremely high modulation speed up to terahertz level. The quasi‐BIC with narrow linewidth is obtained through symmetry‐breaking of nanoelliptical elements, further enhancing the modulation depth. This work satisfies the ultrafast‐speed and high‐efficiency requirement of free‐space all‐optical metasurfaces, including the spatial light modulators in optical computing field.
Long‐Lived Charge Separation Induced Organic Long‐Persistent Luminescence with Circularly Polarized Characteristic
Authors: Wang Tiantian , Liu Man , Feng Wenhui , Cao Rui , Sun Yajing , Wang Lichang , Liu Dongzhi , Wang Yong , Wang Tianyang , Hu Wenping 
Published: January 2023

AbstractResearch on strategies to enable organic long‐persistent luminescence (LPL) emission with circularly polarized luminescence (CPL) characteristics is still very rare due to the lack of an unambiguous light‐emitting mechanism. Herein, circularly polarized long‐persistent luminescence (CPLPL) of a pair of axial chiral molecules as the guest is induced under ambient conditions by exploiting the long‐lived charge separation of the host–guest doping system, whose LPL performance can be further promoted by introducing a rigid polymer network to enhance the charge separation efficiency between host and guest. Based on these CPLPL materials, an effective combination of CPL and LPL properties that is “difficult to copy” is revealed for information encryption and anticounterfeiting applications. This work is expected to stimulate a research boom of CPLPL materials, and will hopefully promote the development of organic LPL systems.
Interactions between Ecosystem Services and Social Economies in the Yangtze River Economic Belt
Authors: Wang Wei , Wang Haofei , Yang Guishan , Zhou Xiuhui 
Published: January 2023

AbstractAn in‐depth understanding of the relationships between ecosystem services (ESs) and socioeconomic (SE) development is an important prerequisite for the coordination and sustainable development of regional human–environmental management strategies. In this study, the coupling coordination model is employed to explore the synergistic and trade‐off relationships between ESs and SE factors.The results show that the ESs in the Yangtze River Economic Belt are currently in a trade‐off stage. At the urban scale, the synergy between water production and other ecosystem functions is more than 20% higher than that of other systems. The proportion of trade‐offs between sediment retention and other ecosystem functions is also high, more than 40% higher than that of other systems. ESs are greatly affected by SE development; the expansion of cultivated land area has the largest negative effect on ESs, and rainfall has the largest negative effect on SE factors. The population has the largest positive effect on ESs, and carbon storage has the largest positive effect on SE factors. This study provides a research method by exploring the patterns of development, interaction, and impact in the Yangtze River Economic Belt, which can provide a basis for the SE development and ESs management of watershed economic zones.
Organic single‐crystal light‐emitting transistors with external quantum efficiency over 20%
Authors: Deng Jian , Zhang Zejian , Sang Pengpeng , Yin Shujun , Zhang Shitong , Li Yuan , Yang Bing , Gu Cheng , Ma Yuguang 
Published: January 2023

AbstractOrganic light‐emitting transistors (OLETs) have attracted increasing attention because of their potential applications in next‐generation displays and high‐energy operating devices. However, the simultaneous achievement of high luminescent efficiency and carrier mobility in organic semiconductors remains challenging because the localized excitons are advantageous for light emission, whereas the delocalized carriers are beneficial for efficient charge migration. Herein, we report an organic single crystal of a cyano‐substituted styrene derivative with balanced mobility yielding a record‐high external quantum efficiency of 20.5% in OLETs. Temperature‐dependent I–V curves and electronic structure analyses based on first‐principles calculations were performed to disclose the underlying mechanism as a band transport, which provides an efficient way to achieve high quantum efficiency in OLETs.
Examining civic engagement in ethnic minority youth populations: A literature review and concept analysis
Authors: Phan Van , Kloos Bret 
Published: January 2023

AbstractRacial reckoning is defined as the subjugation of Black, Indigenous, and people of Color (BIPOC) to racial hierarchies and subordinate groups that influence multiple well‐being outcomes throughout the developmental lifespan and across generations. With the two pandemics of racial reckoning and COVID‐19 amidst a growing controversial political landscape, topics around civic engagement have been brought to the forefront of community conversation. Discussions surrounding civic engagement must go beyond addressing issues of public concern and examine the vehicle in which civic engagement may be delivered. This is becoming increasingly important as civic engagement is one of the main avenues of social change through individual and collective action, particularly regarding racial reckoning and healthcare disparities highlighted by COVID‐19. The paper focuses on civic engagement among ethnic minority youth and young adults. An integrated model of civic engagement was created based off what was learned through this review. This proposed model of civic engagement is meant to be the first step to addressing the gap in civic engagement literature for ethnic minority youth. Weaknesses and future considerations regarding the model will also be discussed, as well as any implications for ethnic minority youth and young adults.
Genomic sequencing in a cohort of individuals with fibular aplasia, tibial campomelia, and oligosyndactyly (FATCO) syndrome
Authors: Matalon Dena R. , Bhoj Elizabeth J. , Li Dong , McDougall Carey , Schindewolf Erica , Khalek Nahla , Wilkens Alisha , McManus Morgan , Deardorff Matthew A. , Zackai Elaine H. 
Published: January 2023

AbstractFibular aplasia, tibial campomelia, and oligosyndactyly (FATCO) syndrome (MIM 246570) is a rare disorder characterized by specific skeletal findings (fibular aplasia, shortened or bowed tibia, and oligosyndactyly of the foot and/or hand). Typically, no other anomalies, craniofacial dysmorphism, or developmental delays are associated. Here we report three unrelated individuals with limb anomalies consistent with FATCO syndrome who have been followed clinically for 5 years. Genetic testing of previously reported individuals with FATCO syndrome has not revealed a genetic diagnosis. However, no broader sequencing approaches have been reported. We describe the results of the three individuals with FATCO syndrome from exome and genome sequencing, all of which was nondiagnostic. Our study suggests that FATCO syndrome is not the result of a simple monogenic etiology.
Solid‐Electrolyte Interphase Chemistries Towards High‐Performance Aqueous Zinc Metal Batteries
Authors: Zhang Wei , He Guanjie 
Published: January 2023

AbstractAqueous zinc metal batteries (AZMBs) are deemed a promising technology for electrochemical energy storage due to their high safety, low cost, and high energy density. However, AZMBs still suffer from severe side reactions, including Zn dendrite formation and intrinsic hydrogen evolution reaction. In contrast to the solid‐electrolyte interphase (SEI) layer that stabilizes Li/Na/K metal anodes in organic electrolytes, it is difficult to form an SEI layer on the Zn surface because of the difficulty in decomposing the salt anions within the narrow electrochemical potential window of water. A team from the University of Adelaide reports a novel pure or hybrid electrolyte with H2O by using dimethyl methylphosphonate (DMMP) as solvent or co‐solvent to construct a uniform and stable phosphate‐based SEI layer (ZnP2O6 and Zn3(PO4)2). As a result, high Coulombic efficiencies and improved capacity retentions are obtained.
Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder
Authors: Siecinski Stephen K. , Giamberardino Stephanie N. , Spanos Marina , Hauser Annalise C. , Gibson Jason R. , Chandrasekhar Tara , Trelles Maria del Pilar , Rockhill Carol M. , Palumbo Michelle L. , Cundiff Allyson Witters , Montgomery Alicia , Siper Paige , Minjarez Mendy , Nowinski Lisa A. , Marler Sarah , Kwee Lydia C. , Shuffrey Lauren C. , Alderman Cheryl , Weissman Jordana , Zappone Brooke , Mullett Jennifer E. , Crosson Hope , Hong Natalie , Luo Sheng , She Lilin , Bhapkar Manjushri , Dean Russell , Scheer Abby , Johnson Jacqueline L. , King Bryan H. , McDougle Christopher J. , Sanders Kevin B. , Kim Soo‐Jeong , Kolevzon Alexander , Veenstra‐VanderWeele Jeremy , Hauser Elizabeth R. , Sikich Linmarie , Gregory Simon G. 
Published: January 2023

AbstractOxytocin (OT), the brain's most abundant neuropeptide, plays an important role in social salience and motivation. Clinical trials of the efficacy of OT in autism spectrum disorder (ASD) have reported mixed results due in part to ASD's complex etiology. We investigated whether genetic and epigenetic variation contribute to variable endogenous OT levels that modulate sensitivity to OT therapy. To carry out this analysis, we integrated genome‐wide profiles of DNA‐methylation, transcriptional activity, and genetic variation with plasma OT levels in 290 participants with ASD enrolled in a randomized controlled trial of OT. Our analysis identified genetic variants with novel association with plasma OT, several of which reside in known ASD risk genes. We also show subtle but statistically significant association of plasma OT levels with peripheral transcriptional activity and DNA‐methylation profiles across several annotated gene sets. These findings broaden our understanding of the effects of the peripheral oxytocin system and provide novel genetic candidates for future studies to decode the complex etiology of ASD and its interaction with OT signaling and OT‐based interventions.Lay SummaryOxytocin (OT) is an abundant chemical produced by neurons that plays an important role in social interaction and motivation. We investigated whether genetic and epigenetic factors contribute to variable OT levels in the blood. To this, we integrated genetic, gene expression, and non‐DNA regulated (epigenetic) signatures with blood OT levels in 290 participants with autism enrolled in an OT clinical trial. We identified genetic association with plasma OT, several of which reside in known autism risk genes. We also show statistically significant association of plasma OT levels with gene expression and epigenetic across several gene pathways. These findings broaden our understanding of the factors that influence OT levels in the blood for future studies to decode the complex presentation of autism and its interaction with OT and OT‐based treatment.
QbD‐based stability‐indicating liquid chromatography (RP‐HPLC) method for the determination of flurbiprofen in cataplasm
Authors: Nathi Rathnakar , Kowtharapu Leela Prasad , Muchakayala Siva Krishna , Konduru Naresh 
Published: January 2023

AbstractA nonsteroidal drug called flurbiprofen (FBN) has analgesic, anti‐inflammatory and antipyretic activity. Currently the determination of FBN in cataplasm does not have any pharmacopeial method. However, the drug substance, tablet and ophthalmic solution formulations do have pharmacopeial methods. The development and validation of an accurate, precise and stability‐indicating analytical method for the determination of FBN in cataplasm formulations is reported. The gradient method was employed for the quantification of FBN in the presence of internal standards such as biphenyl. A nonpolar separation phase (C18, 250 × 4.6 mm, 5 μm Inertsil column; GL Sciences) was used. The optimal flow rate, column oven temperature, injection volume and detector wavelengths were 1.0 ml/min, 40°C, 20 μl and 245 nm, respectively. Mobile phase A was a mixture of water and glacial acetic acid (30:1 v/v) pH adjusted to 2.20 with glacial acetic acid or 1 m NaOH; mobile phase B was methanol (100%). The gradient elution program was [time (min)/% B]: 5/60, 20/70, 25/70, 30/60 and 40/60. The obtained RSDs for the precision and intermediate precision were 0.7 and 0.5%. The percentage recovery ranged from 99.2 to 100.4%. The linear regression coefficient >0.9996 indicates that all peak responses were linear with the concentration. The sample and standard solutions were stable for up to 24 h on the benchtop and in the refrigerator. The critical peaks were well separated from the generated peaks owing to forced degradation, including diluent and placebo peaks. The method validation data and quality by design‐based robustness study results indicate that the developed method is robust and fit for routine use in the quality control laboratory. The proposed method is specific, accurate and precise, and the quality by design utilized the first method for the determination of FBN in cataplasm formulations. Transdermal patches and gels have low extraction capacity and this method is applicable for quantification.
The impact of corruption and public governance quality on family firm business strategy
Authors: Medioli Alice , Marchini Pier Luigi , Mazza Tatiana 
Published: January 2023

AbstractCorruption is a plague with serious economic and social consequences and has a greater impact than people perceive. The impacts on business are severe but often underestimated. The aim of this paper is to analyze the influence of public governance environment on the strategical opportunistic use of related party transactions in family firms. Considering corruption as a good indicator of conditions that boost unethical behavior, the study investigates whether high standard of public governance quality at a regional level, as well as low corruption, helps to reduce specific types of opportunistic transactions. Based on a regression analysis on European‐listed family firms in Italy, France, and Germany, we find that high public governance quality at the regional level reduces companies' opportunistic transactions. The study addresses a gap in the literature, first, because it empirically shows a link between the quality of the context and some unethical business strategies, confirming that a negative context leaves room for opportunistic behaviors and that high standards in the public governance quality discourage firms' opportunistic behaviors through specific transactions and, second, because it focuses on family firms suggesting that a strong family power that controls strategy and decision‐making process, if operate in a bad public quality context, may be involved in opportunistic behaviors.
Board gender diversity and ESG decoupling: Does religiosity matter?
Authors: Eliwa Yasser , Aboud Ahmed , Saleh Ahmed 
Published: January 2023

AbstractIn this paper, we examine the relationship between board gender diversity and environmental, social, and governance (ESG) decoupling and the moderating effect that religiosity has on this relationship. We utilise an international sample of 26,176 firm‐year observations that cover the period from 2005 to 2019. Consistent with the upper echelon theory and the gender socialisation theory, we provide evidence that firms with a more gender‐diversified board of directors tend to engage less in ESG decoupling, and this relationship is more pronounced among firms domiciled in countries with a low level of religiosity. We also find that the effect of religiosity on the relationship between board gender diversity and ESG decoupling is more pronounced for firms that engage in greenwashing and those operating in controversial industry sectors. Our study contributes to the growing debate on ESG decoupling, offering policy insights to regulators and policymakers into the role of board gender diversity and religiosity in reducing unethical managerial behaviour.