bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser ablation‐inductively coupled plasma‐mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma
Authors: Tisza Anna , Klikovits Thomas , Benej Michal , Torok Szilvia , Szeitz Beata , Valko Zsuzsanna , Hoda Mir Alireza , Hegedus Balazs , Bonta Maximilian , Nischkauer Winfried , Hoetzenecker Konrad , Limbeck Andreas , Schelch Karin , Laszlo Viktoria , Megyesfalvi Zsolt , Dome Balazs 
Published: June 2023

AbstractAimsPleural mesothelioma (PM) is a highly aggressive thoracic tumour with poor prognosis. Although reduced tissue drug accumulation is one of the key features of platinum (Pt) resistance, little is known about Pt distribution in human PM.MethodsWe assessed Pt levels of blood samples and surgically resected specimens from 25 PM patients who had received neoadjuvant Pt‐based chemotherapy (CHT). Pt levels and tissue distributions were measured by laser ablation‐inductively coupled plasma‐mass spectrometry and correlated with clinicopathological features.ResultsIn surgically resected PM specimens, mean Pt levels of nontumourous (fibrotic) areas were significantly higher (vs tumourous regions, P = 0.0031). No major heterogeneity of Pt distribution was seen within the tumourous areas. Pt levels correlated neither with the microvessel area nor with apoptosis rate in the tumourous or nontumourous regions. A significant positive correlation was found between serum and both full tissue section and tumourous area mean Pt levels (r = 0.532, P = 0.006, 95% confidence interval [95% CI] 0.161‐0.771 and r = 0.415, P = 0.039, 95% CI 0.011‐0.702, respectively). Furthermore, a significant negative correlation was detected between serum Pt concentrations and elapsed time from the last cycle of CHT (r = −0.474, P = 0.017, 95% CI −0.738‐−0.084). Serum Pt levels correlated negatively with overall survival (OS) (P = 0.029).ConclusionsThere are major differences in drug distribution between tumourous and nontumourous areas of PM specimens. Serum Pt levels significantly correlate with full section and tumourous area average Pt levels, elapsed time from the last CHT cycle, and OS. Further studies investigating clinicopathological factors that modulate tissue Pt concentration and distribution are warranted.
Consumer ethics: An extensive bibliometric review (1995–2021)
Authors: Küster Inés , Vila Natalia 
Published: June 2023

AbstractNowadays, consumer ethics represents a relevant field of review. There have been some attempts to conduct literature reviews; however, these have been few and incomplete. For this reason, this paper follows two main objectives: (1) to develop a performance analysis to measure the impact/perceptibility of academic production on consumer ethics (most cited authors, journals and themes) and (2) to visually present the scientific structure by themes of research in consumer ethics as well as its evolution along time. Using SciMAT software, a comprehensive thematic review is discussed. 568 scientific papers (2569 keywords and 8642 citations) were retrieved from the Web of Science from 1995 to 2021 (May). Our results show three main periods with two main research themes (consumer and corporate social responsibility), which remain relevant themes at the time. Also, some new themes that promote ethical consumption have gained weight or appear over time, some of which are linked to the marketing field (such as experiences, satisfaction, attitudes or privacy among others).
Clinical decision support to reduce unnecessary diagnostic testing for heparin‐induced thrombocytopenia
Authors: Gallo Tyler , Curry Steven C. , Heise C. William , Antonescu Corneliu C. , Raschke Robert A. 
Published: June 2023

SummaryAppropriate evaluation of heparin‐induced thrombocytopenia (HIT) is imperative because of the potentially life‐threatening complications. However, overtesting and overdiagnosis of HIT are common. Our goal was to evaluate the impact of clinical decision support (CDS) based on the HIT computerized‐risk (HIT‐CR) score, designed to reduce unnecessary diagnostic testing. This retrospective observational study evaluated CDS that presented a platelet count versus time graph and 4Ts score calculator to clinicians who initiated a HIT immunoassay order in patients with predicted low risk (HIT‐CR score 0–2). The primary outcome was the proportion of immunoassay orders initiated but cancelled after firing of the CDS advisory. Chart reviews were conducted to assess anticoagulation usage, 4Ts scores and the proportion of patients who had HIT. In a 20‐week period, 319 CDS advisories were presented to users who initiated potentially unnecessary HIT diagnostic testing. The diagnostic test order was discontinued in 80 (25%) patients. Heparin products were continued in 139 (44%) patients, and alternative anticoagulation was not given to 264 (83%). The negative predictive value of the advisory was 98.8% (95% CI: 97.2–99.5). HIT‐CR score‐based CDS can reduce unnecessary diagnostic testing for HIT in patients with a low pretest probability of HIT.
Incidence and prevalence of occupational contact dermatitis in hairdressing apprentices: A 3‐year prospective cohort study
Authors: Franić Zrinka , Ljubojević Hadžavdić Suzana , Babić Željka , Macan Jelena 
Published: June 2023

AbstractBackgroundIt is known that a large number of hairdressing apprentices (HA) develop occupational contact dermatitis (OCD) during schooling, but studies that address prevalence of contact sensitization in HAs with hand eczema are missing.ObjectivesTo assess the prevalence, incidence rate and clinical characteristics of OCD, including contact sensitization, in a sample of Croatian HAs.Materials and MethodsA total of 408 HAs from 25 Croatian towns were examined at the beginning of education and monitored at the end of each school year. Clinical evaluation of skin changes was performed using the Osnabrueck Hand Eczema Severity Index (OHSI). Standard patch test (PT) with baseline and hairdresser series of contact allergens was performed in 46 HAs with skin changes lasting ≥3 months.ResultsThe overall incidence rate of OCD was 32.3/100 person‐years, and the 3‐year prevalence 50.3%. Contact sensitization was found in 14 out of 46 (30.3%) HAs, with 10 of these 14 HAs (71.4%) sensitized to specific hairdressing allergens. The strongest reactions were found to PPD. HAs with positive PT had higher OHSI than HAs with negative patch test (median, IQR: 3, 2–4 vs. 2, 2–4).ConclusionsContact sensitization to specific hairdressing chemicals was found in 71.4% of HAs with a positive patch test, supporting evidence on the early contact sensitization to occupational allergens among HAs.
Expanding School‐Based Health Centers: Sustainable Partnerships and Building Access
Authors: Miehe Jessica 
Published: June 2023

AbstractChildren require accessible, affordable health care to support health and education outcomes. Health care access is affected by children's social determinants of health. School‐based health centers (SBHC) bypass larger social structures and social determinants of health, providing accessible health care to children. New SBHC development should consider university collaboration partnerships to establish funding sustainability. University interprofessional health programs allow for high‐quality, advanced practice nurse care models to staff SBHCs. When developing an SBHC, founders should utilize access theory to ensure conformity between the targeted population's needs and health services. The dimensions of the theory assist in building and evaluating access. As the pandemic continues to cause health care access barriers for children, advocates, and policymakers should focus efforts on sustaining and expanding SBHCs.
Isolation and screening of indigenous nitrifying bacteria to enhance nutrient recovery in an aquaponics system
Authors: Amin Muhamad , Agustono Agustono , Ali Muhamad , Prayugo Prayugo , Hum Nurul Nadiah Mohd Firdaus 
Published: June 2023

AbstractThe recycling processes of aquaponic waste into fertilizers are highly dependent on the type and activity of nitrifying bacteria in the system. This study aims to find indigenous nitrifiers to enhance nutrient recovery in an aquaponics system. Twelve indigenous nitrifiers consisting of ammonia and nitrite‐degrading bacteria were isolated from a local earthen pond of Nile tilapia (Oreochromis niloticus), and two isolates (AQ4 and AQ12) were selected due to their highest capacity to degrade either ammonia or nitrate respectively. Based on the 16S rRNA gene sequences, these isolates were identified as Marinobacter nauticus (AQ4) with 98.64% similarity, and Bacillus sp. (AQ12) with 99.89% similarity. When these bacterial isolates were applied in aquaponics systems with bacterial enhancement (aquaponicsBE), the nutrient recovery was significantly higher compared to the control (aquaponicsctrl), indicated by a 500 g higher total harvested biomass. With a significance value of p < 0.05, aquaponicsBE gives 17% higher crude fat and protein retention in vegetables while in fish 14% higher crude fat was found. Energy retention in vegetables was 23% higher than in the control. Furthermore, fish grew better in the aquaponicsBE system, with 0.6%BW/day higher specific growth rate, and 0.05 better feed conversion ratio compared to that of fish reared in the control.
Lexically Independent Structural Priming in Second Language Online Sentence Comprehension
Authors: Wei Hang , Boland Julie E. , Zhang Chi , Yang Anlin , Yuan Fang 
Published: June 2023

AbstractThis study examined structural priming during online second language (L2) comprehension. In two self‐paced reading experiments, 64 intermediate to advanced Chinese learners of English as a foreign language read coordinated noun phrases where the conjuncts had either the same structure or different structures. Experiment 1 showed that the second conjunct was read faster when it had the same structure as the first. This effect occurred for the structurally marked adjective phrases (e.g., a simple to grasp problem) but only showed a numerical trend for the less marked relative clauses (e.g., a problem that was simple to grasp). Experiment 2 compared unmarked adjective phrases and relative clauses (e.g., a simple problem vs. a problem that was simple) and found significant priming for both. Together, the two experiments showed that L2 comprehension priming could occur without repetition of the lexical head. Moreover, this priming was susceptible to inverse frequency effects, with the less frequent structure exhibiting greater priming.
Peer‐led alcohol intervention for college students: A pilot randomized controlled trial
Authors: Pueyo‐Garrigues Sara , Pardavila‐Belio Miren Idoia , Pueyo‐Garrigues María , Canga‐Armayor Navidad 
Published: June 2023

AbstractThis study aims to assess the preliminary efficacy and feasibility of a brief, peer‐led alcohol intervention to reduce alcohol consumption in binge‐drinking Spanish nursing students. A pilot randomized controlled trial was conducted with 50 first‐year nursing students who were randomly assigned either a 50‐min peer‐led motivational intervention with individual feedback or a control condition. Primary outcomes for testing the preliminary efficacy were alcohol use and alcohol‐related consequences. Quantitative and content analyses of open‐ended survey questions were performed. Participants in the intervention condition significantly reduced binge‐drinking episodes, peak blood alcohol content, and consequences compared to the control group. Principal facilitators were completing the questionnaire during the academic schedule and providing tailored feedback through a graphic report. The main barrier was the unreliability of students' initial commitment. The findings suggest that a brief motivational intervention could be effective for reducing alcohol consumption and alcohol‐related consequences in Spanish college students. Peer counselors and participants reported high satisfaction, indicating that the intervention is feasible. However, a full trial should be conducted taking into account the identified barriers and facilitators.
Decreased metabolic diversity in common beans associated with domestication revealed by untargeted metabolomics, information theory, and molecular networking
Authors: Perez de Souza Leonardo , Bitocchi Elena , Papa Roberto , Tohge Takayuki , Fernie Alisdair R. 
Published: June 2023

SUMMARYThe process of crop domestication leads to a dramatic reduction in the gene expression associated with metabolic diversity. Genes involved in specialized metabolism appear to be particularly affected. Although there is ample evidence of these effects at the genetic level, a reduction in diversity at the metabolite level has been taken for granted despite having never been adequately accessed and quantified. Here we leveraged the high coverage of ultra high performance liquid chromatography‐high‐resolution mass spectrometry based metabolomics to investigate the metabolic diversity in the common bean (Phaseolus vulgaris). Information theory highlights a shift towards lower metabolic diversity and specialization when comparing wild and domesticated bean accessions. Moreover, molecular networking approaches facilitated a broader metabolite annotation than achieved to date, and its integration with gene expression data uncovers a metabolic shift from specialized metabolism towards central metabolism upon domestication of this crop.
IFNλ: balancing the light and dark side in pulmonary infection
Authors: Antos Danielle , Alcorn John F. 
Published: June 2023

ABSTRACT
Interferon (IFN) represents a well-known component of antiviral immunity that has been studied extensively for its mechanisms of action and therapeutic potential when antiviral treatment options are limited. Specifically in the respiratory tract, IFNs are induced directly on viral recognition to limit the spread and transmission of the virus. Recent focus has been on the IFNλ family, which has become an exciting focus in recent years for its potent antiviral and anti-inflammatory activities against viruses infecting barrier sites, including the respiratory tract. However, insights into the interplay between IFNλs and other pulmonary infections are more limited and suggest a more complex role, potentially detrimental, than what was seen during viral infections. Here, we review the role of IFNλs in pulmonary infections, including viral, bacterial, fungal, and multi-pathogen super-infections, and how this may impact future work in the field.
Elucidation of independently modulated genes in
Streptococcus pyogenes
reveals carbon sources that control its expression of hemolytic toxins
Authors: Hirose Yujiro , Poudel Saugat , Sastry Anand V. , Rychel Kevin , Lamoureux Cameron R. , Szubin Richard , Zielinski Daniel C. , Lim Hyun Gyu , Menon Nitasha D. , Bergsten Helena , Uchiyama Satoshi , Hanada Tomoki , Kawabata Shigetada , Palsson Bernhard O. , Nizet Victor 
Published: June 2023

ABSTRACT

Streptococcus pyogenes
can cause a wide variety of acute infections throughout the body of its human host. An underlying transcriptional regulatory network (TRN) is responsible for altering the physiological state of the bacterium to adapt to each unique host environment. Consequently, an in-depth understanding of the comprehensive dynamics of the
S. pyogenes
TRN could inform new therapeutic strategies. Here, we compiled 116 existing high-quality RNA sequencing data sets of invasive
S. pyogenes
serotype M1 and estimated the TRN structure in a top-down fashion by performing independent component analysis (ICA). The algorithm computed 42 independently modulated sets of genes (iModulons). Four iModulons contained the
nga-ifs-slo
virulence-related operon, which allowed us to identify carbon sources that control its expression. In particular, dextrin utilization upregulated the
nga-ifs-slo
operon by activation of two-component regulatory system CovRS-related iModulons, altering bacterial hemolytic activity compared to glucose or maltose utilization. Finally, we show that the iModulon-based TRN structure can be used to simplify the interpretation of noisy bacterial transcriptome data at the infection site.

IMPORTANCE

S. pyogenes
is a pre-eminent human bacterial pathogen that causes a wide variety of acute infections throughout the body of its host. Understanding the comprehensive dynamics of its TRN could inform new therapeutic strategies. Since at least 43
S
.
pyogenes
transcriptional regulators are known, it is often difficult to interpret transcriptomic data from regulon annotations. This study shows the novel ICA-based framework to elucidate the underlying regulatory structure of
S. pyogenes
allows us to interpret the transcriptome profile using data-driven regulons (iModulons). Additionally, the observations of the iModulon architecture lead us to identify the multiple regulatory inputs governing the expression of a virulence-related operon. The iModulons identified in this study serve as a powerful guidepost to further our understanding of
S. pyogenes
TRN structure and dynamics.
When does a Lotka-Volterra model represent microbial interactions? Insights from
in vitro
nasal bacterial communities
Authors: Dedrick Sandra , Warrier Vaishnavi , Lemon Katherine P. , Momeni Babak 
Published: June 2023

ABSTRACT

To alter microbial community composition for therapeutic purposes, an accurate and reliable modeling framework capable of predicting microbial community outcomes is required. Lotka-Volterra (LV) equations have been utilized to describe a breadth of microbial communities, yet, the conditions in which this modeling framework is successful remain unclear. Here, we propose that a set of simple
in vitro
experiments—growing each member in cell-free spent medium obtained from other members—can be used as a test to decide whether an LV model is appropriate for describing microbial interactions of interest. We show that for LV to be a good candidate, the ratio of growth rate to carrying capacity of each isolate when grown in the cell-free spent media of other isolates should remain constant. Using an
in vitro
community of human nasal bacteria as a tractable system, we find that LV can be a good approximation when the environment is low-nutrient (i.e., when growth is limited by the availability of nutrients) and complex (i.e., when multiple resources, rather than a few, determine growth). These findings can help clarify the range of applicability of LV models and reveal when a more complex model may be necessary for predictive modeling of microbial communities.

IMPORTANCE
Although mathematical modeling can be a powerful tool to draw useful insights in microbial ecology, it is crucial to know when a simplified model adequately represents the interactions of interest. Here, we take advantage of bacterial isolates from the human nasal passages as a tractable model system and conclude that the commonly used Lotka-Volterra model can represent interactions among microbes well when the environment is complex (with many interaction mediators) and low-nutrient. Our work highlights the importance of considering both realism and simplicity when choosing a model to represent microbial interactions.
Supplemental Material: Three-dimensional glacial isostatic adjustment modeling reconciles conflicting geographic trends in North American marine isotope stage 5a relative sea level observations
Authors: Thompson Schmitty B. , al. et 
Published: June 2023

<p>Table S1: North American and Caribbean Marine Isotope Stage 5a and 5e sea level indicator data. Figures S1 and S2 on the sensitivity of model predictions to ice margin geometry and plate boundary thickness. </p>
Kangaroo mother care for preterm or low birth weight infants: a systematic review and meta-analysis
Authors: Sivanandan Sindhu , Sankar Mari Jeeva 
Published: June 2023

ImportanceThe Cochrane review (2016) on kangaroo mother care (KMC) demonstrated a significant reduction in the risk of mortality in low birth weight infants. New evidence from large multi-centre randomised trials has been available since its publication.ObjectiveOur systematic review compared the effects of KMC vs conventional care and early (ie, within 24 hours of birth) vs late initiation of KMC on critical outcomes such as neonatal mortality.MethodsEight electronic databases, including PubMed®, Embase, and Cochrane CENTRAL, from inception until March 2022, were searched. All randomised trials comparing KMC vs conventional care or early vs late initiation of KMC in low birth weight or preterm infants were included.Data extraction and synthesisThe review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered with PROSPERO.Main outcomes and measuresThe primary outcome was mortality during birth hospitalization or 28 days of life. Other outcomes included severe infection, hypothermia, exclusive breastfeeding rates, and neurodevelopmental impairment. Results were pooled using fixed-effect and random-effects meta-analyses in RevMan 5.4 and Stata 15.1 (StataCorp, College Station, TX).ResultsIn total, 31 trials with 15 559 infants were included in the review; 27 studies compared KMC with conventional care, while four compared early vs late initiation of KMC. Compared with conventional care, KMC reduces the risks of mortality (relative risk (RR) 0.68; 95% confidence interval (CI) 0.53 to 0.86; 11 trials, 10 505 infants; high certainty evidence) during birth hospitalisation or 28 days of age and probably reduces severe infection until the latest follow-up (RR 0.85, 95% CI 0.79 to 0.92; nine trials; moderate certainty evidence). On subgroup analysis, the reduction in mortality was noted irrespective of gestational age or weight at enrolment, time of initiation, and place of initiation of KMC (hospital or community); the mortality benefits were greater when the daily duration of KMC was at least 8 hours per day than with shorter-duration KMC. Studies comparing early vs late-initiated KMC demonstrated a reduction in neonatal mortality (RR 0.77, 95% CI 0.66 to 0.91; three trials, 3693 infants; high certainty evidence) and a probable decrease in clinical sepsis until 28-days (RR 0.85, 95% CI 0.76 to 0.96; two trials; low certainty evidence) following early initiation of KMC.Conclusions and relevanceThe review provides updated evidence on the effects of KMC on mortality and other critical outcomes in preterm and low birth weight infants. The findings suggest that KMC should preferably be initiated within 24 hours of birth and provided for at least 8 hours daily.
A high-resolution pixel silicon Vertex Detector for open charm measurements with the NA61/SHINE spectrometer at the CERN SPS
Authors: Aduszkiewicz A. , Bajda M. , Baszczyk M. , Bryliíski W. , Brzychczyk J. , Deveaux M. , Dorosz P. , Luise S. Di , Feofilov G. , Gazdzicki M. , Igolkin S. , Jabłoński M. , Kovalenko V. , Koziel M. , Kucewicz W. , Larsen D. , Lazareva T. , Majka Z. , Martinengo P. , Merzlaya A. , Mik L. , Płaneta R. , Staszel P. , Suljic M. , Tefelski D. , Vechernin V. 
Published: June 2023

AbstractThe study of open charm meson production provides an efficient tool for the investigation of the properties of hot and dense matter formed in nucleus–nucleus collisions. The interpretation of the existing di-muon data from the CERN SPS suffers from a lack of knowledge on the mechanism and properties of the open charm particle production. Due to this, the heavy-ion programme of the NA61/SHINE experiment at the CERN SPS has been extended by precise measurements of charm hadrons with short lifetimes. A new Vertex Detector for measurements of the rare processes of open charm production in nucleus–nucleus collisions was designed to meet the challenges of track registration and high resolution in primary and secondary vertex reconstruction. A small-acceptance version of the vertex detector was installed in 2016 and tested with Pb + Pb collisions at 150$$A\,\text{ GeV }\!/\!c$$

A

GeV

/

c

. It was also operating during the physics data taking on Xe + La and Pb + Pb collisions at 150$$A\,\text{ GeV }\!/\!c$$

A

GeV

/

c

conducted in 2017 and 2018. This paper presents the detector design and construction, data calibration, event reconstruction, and analysis procedure.