bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective Nursing Recovery-Oriented Interventions for Individuals With Substance Use Disorder
Authors: Tamayo Niall , Lane Annette 
Published: May 2023

Abstract
Nurses support the recovery of individuals with substance use disorder. How they support individuals, however, may impact the effectiveness of their work. For example, there are various paradigms of recovery that alter interventions. In addition, negative attitudes adopted by clinicians discourage individuals who use substances from accessing healthcare services, experiencing further health deterioration. Alternatively, nurses can enact interventions that promote positive experiences, further supporting the recovery of individuals. Hence, it is beneficial to increase nurses' awareness of effective interventions that promote recovery. The purpose of this literature review is to examine effective nursing interventions that promoted recovery of those with substance use disorders from the perspective of nurses and individuals who received nursing care. The review identified that effective interventions were based on three major themes: person-centered care, empowerment, and maintaining supports and capability enhancement. In addition, literature revealed that some interventions were perceived to be more effective; this depended on whose viewpoint was examined—nurses or individuals with substance use disorders. Finally, there are interventions based on spirituality, culture, advocacy, and self-disclosure that are often disregarded but may be effective. Nurses should utilize the more prominent interventions as they offer the most benefit and integrate interventions that are often overlooked.
Implementing a Screening and Brief Intervention Protocol for Excessive Alcohol Use in a Trauma Center
Authors: Harry Melissa L. , Lake Erica , Woehrle Theo A. , Heger Anna Mae C. , Vogel Linda E. 
Published: May 2023

Abstract

Objective
The aim of this healthcare improvement project was to evaluate healthcare provider use of screening and brief interventions (SBIs) for patients screening positive for alcohol at an upper Midwestern adult trauma center transitioning from Level II to Level I.

Method
Trauma registry data for 2,112 adult patients with trauma who screened positive for alcohol were compared between three periods: pre-formal-SBI protocol (January 1, 2010, to November 29, 2011); first post-SBI protocol (February 6, 2012, to April 17, 2016) after protocol implementation, healthcare provider training, and documentation changes; and second post-SBI protocol (June 1, 2016, to June, 30, 2019) after additional training and process improvements. Data analysis included descriptive statistics and logistic regression for comparisons over time and between admitting services.

Results
For the trauma admitting service, SBI rates increased from 32% to 90% over time, compared with 18%–51% for other admitting services combined. Trauma-service-admitted patients screening positive for alcohol had higher odds of receiving a brief intervention than other admitting services in each period in adjusted models: pre-SBI (OR = 1.99, 95% CI [1.15, 3.43], p = .014), first post-SBI (OR = 2.89, 95% CI [2.04, 4.11], p < .001), and second post-SBI (OR = 11.40, 95% CI [6.27, 20.75], p < .001) protocol periods. Within trauma service admissions, first post-SBI protocol (OR = 2.15, 95% CI [1.64, 2.82], p < .001) and second post-SBI protocol (OR = 21.56, 95% CI [14.61, 31.81], p < .001) periods had higher rates and odds of receiving an SBI than the pre-SBI protocol period.

Conclusion
The number of SBIs completed with alcohol-positive adult patients with trauma significantly increased over time through SBI protocol implementation, healthcare provider training, and process improvements, suggesting other admitting services with lower SBI rates could adopt similar approaches.
An Integrative Review of Programs for Managing Nurses' Substance Use Disorder in the Workplace
Authors: Luurila Katrimaija , Kangasniemi Mari , Häggman-Laitila Arja 
Published: May 2023

Abstract

Background
Nurses' substance use disorder (SUD) endangers patient safety and decreases nurses' work ability and health. To better understand the methods, treatments, and benefits of the programs used to monitor nurses with SUD and promote their recovery, a systematic review of international research is needed.

Aim
The aim was to gather, evaluate, and summarize empirical research on programs for managing nurses with SUD.

Design
An integrative review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis instructions.

Method
Systematic searches were conducted in the CINAHL, PsycInfo, PubMed, Scopus, and Web of Science databases between 2006 and 2020, complemented with manual searches. Articles were selected based on inclusion, exclusion, and method-specific evaluation criteria. The data were analyzed narratively.

Results
The review identified 12 studies of which nine focused on recovery and monitoring programs for nurses with SUD or other impairment and three concerned training programs for nurse supervisors or worksite monitors. The programs were described in terms of their target groups, goals, and theoretical basis. The programs' methods and benefits were described together with challenges in their implementation.

Conclusion
There has been little research on programs for nurses with SUD, the programs that exist are heterogenous, and the evidence available in this field is weak. Further research and developmental work are needed on preventive and early detection programs as well as rehabilitative programs and programs supporting reentry to workplaces. In addition, programs should not be restricted to nurses and their supervisors; colleagues and work communities should also be involved.
Congenital myasthenic syndrome due to a genetic mutation
Authors: Tsalta-Mladenov Mihael , Levkova Mariya , Georgieva Darina , Andonova Silva 
Published: May 2023

ABSTRACT
Congenital myasthenic syndrome (CMS) is a group of rare genetic disorders that mimics the symptoms of myasthenia gravis, but it is due to a genetic defect. We present a case of a male CMS patient, and the course of the disease through the years. The patient initially presented with generalized muscle weakness and difficulty swallowing. During the follow-up, he developed difficulty in chewing, bilateral external ophthalmoparesis with an almost full block of eye movements and bulbar syndrome. The case illustrates both the clinical heterogeneity and the progressive worsening of the symptoms of the disease over the years. The optimal treatment for CMS is based on the molecular defect and its localization in the neuromuscular junction. In our case, treatment with pyridostigmine resulted in good long-term control of symptoms. As a result of the patient's good compliance with treatment, he was not admitted to hospital because of respiratory distress. The lack of a unified protocol for the treatment of CMS highlights the need for a more personalized approach when dealing with patients with rare diseases.
Association between the diagnostic classification of newly diagnosed coronary artery disease and future heart failure development
Authors: Williams Brent A. , Voyce Stephen , Blankenship James C. , Chang Alexander R. 
Published: May 2023

Objective
The first clinical manifestation of coronary artery disease (CAD) varies widely from unheralded myocardial infarction (MI) to mild, incidentally detected disease. The primary objective of this study was to quantify the association between different initial CAD diagnostic classifications and future heart failure.

Methods
This retrospective study incorporated the electronic health record of a single integrated health care system. Newly diagnosed CAD was classified into a mutually exclusive hierarchy as MI, CAD with coronary artery bypass graft (CABG), CAD with percutaneous coronary intervention, CAD only, unstable angina, and stable angina. An acute CAD presentation was defined when the diagnosis was associated with a hospital admission. New heart failure was identified after the CAD diagnosis.

Results
Among 28 693 newly diagnosed CAD patients, initial presentation was acute in 47% and manifested as MI in 26%. Within 30 days of CAD diagnosis, MI [hazard ratio (HR) = 5.1; 95% confidence interval: 4.1–6.5] and unstable angina (3.2; 2.4–4.4) classifications were associated with the highest heart failure risk (compared to stable angina), as was acute presentation (2.9; 2.7–3.2). Among stable, heart failure-free CAD patients followed on average 7.4 years, initial MI (adjusted HR = 1.6; 1.4–1.7) and CAD with CABG (1.5; 1.2–1.8) were associated with higher long-term heart failure risk, but an initial acute presentation was not (1.0; 0.9–1.0).

Conclusion
Nearly 50% of initial CAD diagnoses are associated with hospitalization, and these patients are at high risk of early heart failure. Among stable CAD patients, MI remained the diagnostic classification associated with the highest long-term heart failure risk, however, having an initial acute CAD presentation was not associated with long-term heart failure.
Posttraumatic osteoarthritis: from basic science to clinical implications
Authors: Haller Justin M. , van der Meulen Marjolein C H. , Olson Steven , Anderson Donald , Marsh J. Lawrence , Working Zachary 
Published: May 2023

Abstract
Posttraumatic osteoarthritis (PTOA) is a subset of osteoarthritis that occurs after joint injury and is associated with degradation of articular cartilage and subchondral bone. As compared with primary osteoarthritis, PTOA occurs in a time window initiated by a traumatic event resulting in damage to layers of joint structure and alterations in joint shape. As techniques in open reduction and internal fixation continue to mature, our success in preventing posttraumatic osteoarthritis has not kept pace. Advances in research in the subchondral bone, inflammatory response, and joint mechanics continue to open our understanding of this posttraumatic process. In addition, there are possibilities emerging as biological agents to therapeutically alter the progression of PTOA.
COMBINATION THERAPY WITH A SENSE OLIGONUCLEOTIDE TO INDUCIBLE NITRIC OXIDE SYNTHASE MRNA AND HUMAN SOLUBLE THROMBOMODULIN IMPROVES SURVIVAL OF SEPSIS MODEL RATS AFTER PARTIAL HEPATECTOMY
Authors: Nakatake Richi , Okuyama Tetsuya , Kotsuka Masaya , Ishizaki Morihiko , Kitade Hiroaki , Yoshizawa Katsuhiko , Tolba Rene H. , Nishizawa Mikio , Sekimoto Mitsugu 
Published: May 2023

ABSTRACT
Sepsis after a major hepatectomy is a critical problem. In septic shock, the inflammatory mediator, nitric oxide (NO), is overproduced in hepatocytes and macrophages. The natural antisense (AS) transcripts, non-coding RNAs, are transcribed from a gene that encodes inducible nitric oxide synthase (iNOS). iNOS AS transcripts interact with and stabilize iNOS mRNAs. A single-stranded “sense oligonucleotide” (designated as SO1) corresponding to the iNOS mRNA sequence inhibits mRNA-AS transcript interactions and reduces iNOS mRNA levels in rat hepatocytes. In contrast, recombinant human soluble thrombomodulin (rTM) treats disseminated intravascular coagulopathy by suppressing coagulation, inflammation, and apoptosis. In this study, the combination therapy of SO1 and a low dose of rTM was evaluated for hepatoprotection in a rat septic shock model after partial hepatectomy. Rats underwent 70% hepatectomy, followed by intravenous (i.v.) injection of lipopolysaccharide (LPS) after 48 h. SO1 was injected (i.v.) simultaneously with LPS, whereas rTM was injected (i.v.) 1 h before LPS injection. Similarly to our previous report, SO1 increased survival after LPS injection. When rTM, which has different mechanisms of action, was combined with SO1, it did not interfere with the effect of SO1 and showed a significant increase in survival compared with LPS alone treatment. In serum, the combined treatment decreased NO levels. In the liver, the combined treatment inhibited iNOS mRNA and protein expression. A decreased iNOS AS transcript expression by the combined treatment was also observed. The combined treatment decreased mRNA expression of the inflammatory and pro-apoptotic genes while increasing that of the anti-apoptotic gene. Furthermore, the combined treatment reduced the number of myeloperoxidase-positive cells. These results suggested that the combination of SO1 and rTM has therapeutic potential for sepsis.
A COMPARATIVE ANALYSIS TO DETERMINE THE OPTIMUM HISTONE DEACETYLASE INHIBITORS AND ADMINISTRATION ROUTE FOR IMPROVING SURVIVAL AND ORGAN INJURY IN RATS AFTER HEMORRHAGIC SHOCK
Authors: Niu Kunwei , Yang Long , Song Wenjie , Liu Zhengcai , Yuan Juzheng , Zhang Hong , Zhang Wenjie , Wang Jianlin , Tao Kaishan 
Published: May 2023

ABSTRACT

Objective: Histone deacetylase inhibitors (HDACIs) have been reported to improve survival in rats with hemorrhagic shock (HS). However, no consensus exists on the most effective HDACIs and their administration routes. We herein aimed to determine the optimal HDACIs and administration route in rats with HS. Methods: Survival analysis: In experiment I, male Sprague-Dawley rats were subjected to HS (mean arterial pressure [MAP] was maintained at 30–40 mm Hg for 20 min), and intravenously injected with the following agents (n = 8 per group): (1) no treatment, (2) vehicle (VEH), (3) entinostat (MS-275), (4) [N-((6-(Hydroxyamino)-6-oxohexyl)oxy)-3,5-dimethylbenzamide] (LMK-235), (5) tubastatin A, (6) trichostatin A (TSA), and (7) sirtinol. In experiment II, rats were intraperitoneally injected with TSA. Mechanism research: In experiments I and II, rats were observed for 3 h, after which blood samples and liver, heart, and lung tissues were harvested. Results: In experiment I, 75% rats in the VEH group but only 25% rats in the LMK-235 and sirtinol groups died within ≤5 h of treatment, whereas the survival of rats in the MS-275, tubastatin A, and TSA groups was significantly prolonged. MS-275, LMK-235, tubastatin A, and TSA significantly reduced histopathological scores, apoptosis cell numbers, and inflammatory cytokine levels. In experiment II, the survival was longer after i.v. TSA treatment than after i.p. TSA treatment, and the IL-6 levels in the heart were significantly lower in rat who received i.p. TSA treatment than in those who received i.v. TSA treatment. Conclusions: The i.v. effect was superior to the i.p. effect, while nonselective and isoform-specific classes I and IIb HDACIs had similar effects.
ATAXIA TELANGIECTASIA MUTATED PROTECTS AGAINST LIPOPOLYSACCARIDE-INDUCED BLOOD-BRAIN BARRIER DISRUPTION BY REGULATING ATK/DRP1-MEDIATED MITOCHONDRIAL HOMEOSTASIS
Authors: Luo Shiyuan , Lyu Zhuochen , Ge Lingling , Li Yinjiao , Liu Yuqi , Yuan Yuan , Zhao Rui , Huang Lei , Zhao Jianyuan , Huang Hongjun , Luo Yan 
Published: May 2023

ABSTRACT

Background: Protein kinase ataxia telangiectasia mutated (ATM) regulates the function of endothelial cells and responds quickly to endotoxin. However, the function of ATM in lipopolysaccharide (LPS)-induced blood-brain barrier (BBB) disruption remains unknown. This study aimed to investigate the role and underlying mechanism of ATM in the regulation of the BBB function in sepsis. Methods: We used LPS to induce BBB disruption in vivo and to establish an in vitro model of cerebrovascular endothelial cells. Blood-brain barrier disruption was assessed by measuring Evans blue leakage and expression of vascular permeability regulators. To investigate the role of ATM, its inhibitor AZD1390 and clinically approved doxorubicin, an anthracycline that can activate ATM, were administered as scheduled. To explore the underlying mechanism, protein kinase B (AKT) inhibitor MK-2206 was administered to block the AKT/dynamin-related protein 1 (DRP1) pathway. Results: Lipopolysaccharide challenge induced significant BBB disruption, ATM activation, and mitochondrial translocation. Inhibiting ATM with AZD1390 aggravated BBB permeability as well as the following neuroinflammation and neuronal injury, while activation of ATM by doxorubicin abrogated these defects. Further results obtained in brain microvascular endothelial cells showed that ATM inhibition reduced the phosphorylation of DRP1 at serine (S) 637, promoted excessive mitochondrial fission, and resulted in mitochondrial malfunction. By activating ATM, doxorubicin increased the protein binding between ATM and AKT and promoted the phosphorylated activation of AKT at S473, which could directly phosphorylate DRP1 at S637 to repress excessive mitochondrial fission. Consistently, the protective role of ATM was abolished by the AKT inhibitor MK-2206. Conclusions: Ataxia telangiectasia mutated protects against LPS-induced BBB disruption by regulating mitochondrial homeostasis, at least in part, through the AKT/DRP1 pathway.
Nationwide use and outcome of Minimally Invasive Distal Pancreatectomy in IDEAL Stage IV following a Training Program and Randomized Trial
Authors: Korrel Maarten , van Hilst Jony , Bosscha Koop , Busch Olivier R.C. , Daams Freek , van Dam Ronald , van Eijck Casper H.J. , Festen Sebastiaan , Groot Koerkamp Bas , van der Harst Erwin , Lips Daan , Luyer Misha , de Meijer Vincent E. , Mieog Sven , Molenaar Quintus , Patijn Gijs , van Santvoort Hjalmar , van der Schelling George , Stommel Martijn W.J. , Besselink Marc G. ,   for the Dutch Pancreatic Cancer Group
Published: May 2023

Objective:
To assess the nationwide long-term uptake and outcomes of minimally invasive distal pancreatectomy (MIDP) after a nationwide training program and randomized trial.

Background:
Two randomized trials demonstrated the superiority of MIDP over open distal pancreatectomy (ODP) in terms of functional recovery and hospital stay. Data on implementation of MIDP on a nationwide level are lacking.

Methods:
Nationwide audit-based study including consecutive patients after MIDP and ODP in 16 centers in the Dutch Pancreatic Cancer Audit (2014-2021). The cohort was divided into three periods: early implementation, during the LEOPARD randomized trial, and late implementation. Primary endpoints were MIDP implementation rate and textbook outcome.

Results:
Overall, 1496 patients were included with 848 MIDP (56.5%) and 648 ODP (43.5%). From the early to the late implementation period, the use of MIDP increased from 48.6% to 63.0% and of robotic MIDP from 5.5% to 29.7% (P<0.001). The overall use of MIDP (45% to 75%) and robotic MIDP (1% to 84%) varied widely between centers (P<0.001). In the late implementation period, 5/16 centers performed >75% of procedures as MIDP. After MIDP, in-hospital mortality and textbook outcome remained stable over time. In the late implementation period, ODP was more often performed in ASA score III-IV (24.9% vs. 35.7%, P=0.001), pancreatic cancer (24.2% vs. 45.9%, P<0.001), vascular involvement (4.6% vs. 21.9%, P<0.001), and multivisceral involvement (10.5% vs. 25.3%, P<0.001). After MIDP, shorter hospital stay (median 7 vs. 8 d, P<0.001) and less blood loss (median 150 vs. 500 mL, P<0.001), but more grade B/C postoperative pancreatic fistula (24.4% vs. 17.2%, P=0.008) occurred as compared to ODP.

Conclusion:
A sustained nationwide implementation of MIDP after a successful training program and randomized trial was obtained with satisfactory outcomes. Future studies should assess the considerable variation in the use of MIDP between centers and, especially, robotic MIDP.
Heat-shock inducible clonal analysis reveals the stepwise establishment of cell fates in the rice stem
Authors: Tsuda Katsutoshi , Maeno Akiteru , Nonomura Ken-Ichi 
Published: May 2023

AbstractThe stem, consisting of nodes and internodes, is one of the major organs in seed plants. In contrast to other organs, however, processes of stem development remain elusive, especially when nodes and internodes are initiated. By introducing an intron into theCrerecombinase gene, we established a heat-shock inducible clonal analysis system in a single binary vector and applied it to the stem in the flag leaf phytomer of rice. With detailed characterizations of stem development, we show that cell fate acquisition for each domain of the stem occurs stepwise. Cell fates for a single phytomer and the foot (non-elongating domain at the stem base) were established in the shoot apical meristem by one plastochron before the leaf initiation. The fate acquisition for the node occurred just before the leaf initiation, separating cell lineages for leaves and stems. Subsequently, fates for the axillary bud were established in early leaf primordia. Finally, cells committed to the internode emerged from, at most, a few tiers of cells when the stem epidermis was at the 12∼25 celled stage. Thus, the internode is the last part of the stem whose cell fate is established. This study provides a groundwork to unveil underlying molecular mechanisms in stem development and a useful tool for clonal analysis, which can be applied to various species.
Diagnostic accuracy of MRI in diagnosing Cardiac Sarcoidosis - A Meta-analysis
Authors: Sabuwala Naqeeya Mustafa , Raval Dwija , Parikh Hetvi , Saiyed Falak , Desai Dev 
Published: May 2023

AbstractIntroductionA multisystem inflammatory illness-sarcoidosis is characterized by organ failure, noncaseating granuloma development, and inflammation. The most frequently affected tissues are the lungs and pulmonary lymph nodes, although other tissues can also be affected including the heart. Cardiac Sarcoidosis can be lethal and result in conduction abnormalities, arrhythmias, and sudden cardiac death. As endocardial biopsy is invasive, Advanced imaging techniques, such as cardiac magnetic resonance (CMR) could be used to diagnose cardiac sarcoidosis and evaluate prognosis. Small and focal cardiac abnormalities have been successfully identified by (DE)-MRI. This comprehensive study and meta-analysis was carried out to aid in the CS diagnosis.MethodologyUsing a strategy based on the search terms-sarcoidosis and CMR/MRI separately, we searched-Pubmed, Google Scholar, Embose, Cochrane Library. Studies were disqualified if they lacked enough data to fill out a 2*2 contingency table. We strictly adhered to the Japanese criteria for diagnosing cases. Data from 12 studies with a total of 785 cases with TP of 212 was included.ResultsWe found the cardiac MRI Sensitivity= 0.934 (95% CI = 0.904 to 0.964), Specificity = 0.875 (95% CI = 0.826 to 0.923), PPV= 0.752 (95% CI = 0.682 to 0.822), Younden index= 0.808 and AUC (Area under curve) for ROC plot= 0.904 with a Diagnostic accuracy of 0.892 for detecting sarcoidosis.ConclusionCardiac MRI is a good and reliable screening and diagnostic tool that can be employed as a non-interventional method for diagnosis of Cardiac Sarcoidosis and future prognosis. Diagnostic accuracy of cardiac sarcoidosis using MRI, a meta-analysis.