bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Hydrological Conditions and Dengue Fever Incidence in Coastal Southeastern China From 2013 to 2019
Authors: Li Chuanxi , Wang Zhendong , Yan Yu , Qu Yinan , Hou Liangyu , Li Yijie , Chu Cordia , Woodward Alistair , Schikowski Tamara , Saldiva Paulo Hilário Nascimento , Liu Qiyong , Zhao Qi , Ma Wei 
Published: January 2023

ImportanceDengue fever is a climate-sensitive infectious disease. However, its association with local hydrological conditions and the role of city development remain unclear.ObjectiveTo quantify the association between hydrological conditions and dengue fever incidence in China and to explore the modification role of city development in this association.Design, Setting, and ParticipantsThis cross-sectional study collected data between January 1, 2013, and December 31, 2019, from 54 cities in 4 coastal provinces in southeast China. The Standardized Precipitation Evapotranspiration Index (SPEI) was calculated from ambient temperature and precipitation, with SPEI thresholds of 2 for extreme wet conditions and −2 for extreme dry conditions. The SPEI–dengue fever incidence association was examined over a 6-month lag, and the modification roles of 5 city development dimensions were assessed. Data were analyzed in May 2022.ExposuresCity-level monthly temperature, precipitation, SPEI, and annual city development indicators from 2013 to 2019.Main Outcomes and MeasuresThe primary outcome was city-level monthly dengue fever incidence. Spatiotemporal bayesian hierarchal models were used to examine the SPEI–dengue fever incidence association over a 6-month lag period. An interaction term between SPEI and each city development indicator was added into the model to assess the modification role of city development.ResultsIncluded in the analysis were 70 006 dengue fever cases reported in 54 cities in 4 provinces in China from 2013 to 2019. Overall, a U-shaped cumulative curve was observed, with wet and dry conditions both associated with increased dengue fever risk. The relative risk [RR] peaked at a 1-month lag for extreme wet conditions (1.27; 95% credible interval [CrI], 1.05-1.53) and at a 6-month lag for extreme dry conditions (1.63; 95% CrI, 1.29-2.05). The RRs of extreme wet and dry conditions were greater in areas with limited economic development, health care resources, and income per capita. Extreme dry conditions were higher and prolonged in areas with more green space per capita (RR, 1.84; 95% CrI, 1.37-2.46). Highly urbanized areas had a higher risk of dengue fever after extreme wet conditions (RR, 1.80; 95% CrI, 1.26-2.56), while less urbanized areas had the highest risk of dengue fever in extreme dry conditions (RR, 1.70; 95% CrI, 1.11-2.60).Conclusions and RelevanceResults of this study showed that extreme hydrological conditions were associated with increased dengue fever incidence within a 6-month lag period, with different dimensions of city development playing various modification roles in this association. These findings may help in developing climate change adaptation strategies and public health interventions against dengue fever.
Association of Women Surgeons’ Comprehensive Initiative for Healthy Surgical Families During Residency and Fellowship Training
Authors: Johnson Helen M. , Torres Madeline B. , Möller Mecker G. , Cannada Lisa , Nosanov Lauren B. , Riner Andrea N. , Tatebe Leah C. , Reyna Chantal , Altieri Maria S. 
Published: January 2023

ImportanceThe lack of family-friendly policies continues to contribute to the underrepresentation and attrition of surgical trainees. Women in surgery face unique challenges in balancing surgical education with personal and family needs.ObservationsThe Association of Women Surgeons is committed to supporting surgical families and developing equitable family-friendly guidelines. Herein we detail recommendations for adequate paid parental leave, access to childcare, breastfeeding support, and insurance coverage of fertility preservation and assisted reproductive technology.Conclusions and RelevanceThe specific recommendations outlined in this document form the basis of a comprehensive initiative for supporting surgical families.
Neuro‐adaptive finite‐time optimal tracking control for permanent magnet synchronous motors with full‐state constraints
Authors: Ding Lusong , Wang Wei , Yu Yang 
Published: January 2023

SummaryIn this article, the optimal tracking control problem is investigated for permanent magnet synchronous motors (PMSMs) with full‐state constraints. By constructing multiple barrier‐type performance index functions, a neuro‐adaptive finite‐time optimized control scheme is presented under identifier‐actor‐critic architecture, where the virtual control laws and the actual laws are designed to optimize corresponding subsystems. It is proven that all signals of the closed‐loop system are uniformly ultimately bounded under the proposed control strategy, and the position tracking error converges to a small neighborhood of the origin in finite time. Besides, the system states are constrained to the effective operation range all the time. Finally, the simulation results and comparisons are carried out to further demonstrate the effectiveness of the proposed optimal control approach.
Leaf‐Like TENGs for Harvesting Gentle Wind Energy at An Air Velocity as Low as 0.2 m s−1
Authors: Li Hao , Wen Jing , Ou Zhiqiang , Su Erming , Xing Fangjing , Yang Yuhan , Sun Yanshuo , Wang Zhong Lin , Chen Baodong 
Published: January 2023

AbstractExisting technologies for harvesting electrical energy from gentle wind face an enormous challenge due to the limitations of cut‐in and rated wind speed. Here, a leaf‐like triboelectric nanogenerator (LL‐TENG) is proposed that uses contact electrification caused by the damped forced vibration of topology‐optimized structure consisting of flexible leaf, vein bearing plate, and counterweight piece. The effectiveness of the topology‐optimized leaf‐like structure is studied, which solves the problem of reduced output due to electrostatic adsorption between the leaf surfaces while reducing the cut‐in (0.2 m s−1) and rated wind speed (2.5 m s−1). The LL‐TENG unit having small dimensions of 40 cm−2 (mass of 9.7 g) at a gentle wind of 2.5 m s−1 exhibits outstanding electrical performances, which produces an open‐circuit voltage of 338 V, a short‐circuit current of 7.9 µA and the transferred charge density of 62.5 µC m−2 with a low resonant frequency of 4 Hz, giving an instantaneous peak power of 2 mW. A distributed power source consists of the five LL‐TENGs in parallel is developed by designed self‐adaptive structure, for which the peak power output reaches 3.98 mW, and its practicability and durability are successfully demonstrated. This study is a promising distributed power source technology to drive electronics in gentle wind outdoor environments.
Amorphous F‐doped TiOx Caulked SnO2 Electron Transport Layer for Flexible Perovskite Solar Cells with Efficiency Exceeding 22.5%
Authors: Zhang Linghui , Fu Chao , Wang Shi , Wang Minhuan , Wang Ruiting , Xiang Shengling , Wang Zhiyong , Liu Jing , Ma Hongru , Wang Yudi , Yan Ying , Chen Min , Shi Lei , Dong Qingshun , Bian Jiming , Shi Yantao 
Published: January 2023

AbstractFlexible perovskite solar cells (f‐PSCs) show great promise in portable‐power applications (e.g., chargers, drones) and low‐cost, scalable productions (e.g., roll‐to‐roll). However, in conventional n–i–p architecture f‐PSCs, the low‐temperature processed metal oxide electron transport layers (ETLs) usually suffer from high resistance and severe defects that limit the power conversion efficiency (PCE) improvement of f‐PSCs. Besides the enhancement in the mobility of metal oxide and passivation for perovskite/ETL interfacial defects reported in previous literature, herein, the electron transport loss between the metal oxide nanocrystallines within the ETL is studied by introducing an amorphous F‐doped TiOx (F‐TiOx) caulked crystalline SnO2 composite ETL. The F‐TiOx in this novel composite ETL acts as an interstitial medium between adjacent SnO2 nanocrystallines, which can provide more electron transport channels, effectively passivate oxygen vacancies, and optimize the energy level arrangement, thus significantly enhancing the electron mobility of ETL and reducing the charge transport losses. The composite ETL‐based f‐PSCs achieve a high PCE of 22.70% and good operational stability. Furthermore, a moderate roughness of the composite ETL endows f‐PSCs with superior mechanical reliability by virtue of a strong coupling at the ETL/perovskite interface, by which the f‐PSCs can maintain 82.11% of their initial PCE after 4000 bending cycles.
Highly Efficient and Stable Wide‐Bandgap Perovskite Solar Cells via Strain Management
Authors: Hang Pengjie , Kan Chenxia , Li Biao , Yao Yuxin , Hu Zechen , Zhang Yiqiang , Xie Jiangsheng , Wang Ying , Yang Deren , Yu Xuegong 
Published: January 2023

AbstractWide‐bandgap (WBG) perovskite solar cells (PSCs) with high performance and stability are in considerable demand to boost tandem solar cell efficiencies. Perovskite bandgap broadening results in a high barrier for enhancing the efficiency of PSCs and phase segregation in perovskite. In this study, it is shown that the residual strain is the key factor affecting the WBG perovskite device efficiency and stability. The dimethyl sulfoxide addition helps lead halide with opening the layer spacing to form intermediate phases that provide more nucleation sites to eliminate lattice mismatch with organic components, which dominates the strain effects on the WBG perovskite growth in a sequential deposition. By minimizing the strain, 1.67 and 1.77 eV nip devices with record efficiencies of 22.28% and 20.45%, respectively, can be achieved. The greatly suppressed phase segregation enables the devices with retained 90–95% of initial efficiency over 4000 h of damp stability and 80–90% of initial efficiency over 700 h of maximum‐power‐point (MPP) stability. Besides, the 1.67 eV pin devices can achieve a competitive 22.3% efficiency with considerable damp‐heat, pre‐ultraviolet (pre‐UV) aging and MPP tracking stability according to IEC 61215. The final efficiency of more than 28.3% for the perovskite/Si tandem is obtained.
Efficient Perovskite/Silicon Tandem Solar Cells on Industrially Compatible Textured Silicon
Authors: Luo Xin , Luo Haowen , Li Hongjiang , Xia Rui , Zheng Xuntian , Huang Zilong , Liu Zhou , Gao Han , Zhang Xueling , Li Songlin , Feng Zhiqiang , Chen Yifeng , Tan Hairen 
Published: January 2023

AbstractMonolithic perovskite/silicon tandem solar cells promise power‐conversion efficiencies (PCEs) exceeding the Shockley‐Queisser limit of single‐junction solar cells. The conformal deposition of perovskites on industrially feasible textured silicon solar cells allows for both lowered manufacturing costs and a higher matched photocurrent density, compared to state‐of‐the‐art tandems using front‐side flat or mildly textured silicon. However, the inferior crystal quality of perovskite films grown on fully‐textured silicon compromises the photovoltaic performance. Here, an anion‐engineered additive strategy is developed to control the crystallization process of wide‐bandgap perovskite films, which enables improved film crystallinity, reduced trap density, and conformal deposition on industrially textured silicon. This strategy allows the fabrication of 28.6%‐efficient perovskite/silicon heterojunction tandem solar cells (certified 27.9%, 1 cm2). This approach is compatible with the scalable fabrication of tandems on industrially textured silicon, demonstrating an efficiency of 25.1% for an aperture area of 16 cm2. The anion‐engineered additive significantly improves the operating stability of wide‐bandgap perovskite solar cells, and the encapsulated tandem solar cells retain over 80% of their initial performance following 2000 h of operation under full 1‐sun illumination in ambient conditions.
Molecular Generative Model via Retrosynthetically Prepared Chemical Building Block Assembly
Authors: Seo Seonghwan , Lim Jaechang , Kim Woo Youn 
Published: January 2023

AbstractDeep generative models are attracting attention as a smart molecular design strategy. However, previous models often render molecules with low synthesizability, hindering their real‐world applications. Here, a novel graph‐based conditional generative model which makes molecules by tailoring retrosynthetically prepared chemical building blocks until achieving target properties in an auto‐regressive fashion is proposed. This strategy improves the synthesizability and property control of the resulting molecules and also helps learn how to select appropriate building blocks and bind them together to achieve target properties. By applying a negative sampling method to the selection process of building blocks, this model overcame a critical limitation of previous fragment‐based models, which can only use molecules from the training set during generation. As a result, the model works equally well with unseen building blocks without sacrificing computational efficiency. It is demonstrated that the model can generate potential inhibitors with high docking scores against the 3CL protease of SARS‐COV‐2.
A biallelic frameshift indel in PPP1R35 as a cause of primary microcephaly
Authors: Dawood Moez , Akay Gulsen , Mitani Tadahiro , Marafi Dana , Fatih Jawid M. , Gezdirici Alper , Najmabadi Hossein , Kahrizi Kimia , Punetha Jaya , Grochowski Christopher M. , Du Haowei , Jolly Angad , Li He , Coban‐Akdemir Zeynep , Sedlazeck Fritz J. , Hunter Jill V. , Jhangiani Shalini N. , Muzny Donna , Pehlivan Davut , Posey Jennifer E. , Carvalho Claudia M. B. , Gibbs Richard A. , Lupski James R. 
Published: January 2023

AbstractProtein phosphatase 1 regulatory subunit 35 (PPP1R35) encodes a centrosomal protein required for recruiting microtubule‐binding elongation machinery. Several proteins in this centriole biogenesis pathway correspond to established primary microcephaly (MCPH) genes, and multiple model organism studies hypothesize PPP1R35 as a candidate MCPH gene. Here, using exome sequencing (ES) and family‐based rare variant analyses, we report a homozygous, frameshifting indel deleting the canonical stop codon in the last exon of PPP1R35 [Chr7: c.753_*3delGGAAGCGTAGACCinsCG (p.Trp251Cysfs*22)]; the variant allele maps in a 3.7 Mb block of absence of heterozygosity (AOH) in a proband with severe MCPH (−4.3 SD at birth, −6.1 SD by 42 months), pachygyria, and global developmental delay from a consanguineous Turkish kindred. Droplet digital PCR (ddPCR) confirmed mutant mRNA expression in fibroblasts. In silico prediction of the translation of mutant PPP1R35 is expected to be elongated by 18 amino acids before encountering a downstream stop codon. This complex indel allele is absent in public databases (ClinVar, gnomAD, ARIC, 1000 genomes) and our in‐house database of 14,000+ exomes including 1800+ Turkish exomes supporting predicted pathogenicity. Comprehensive literature searches for PPP1R35 variants yielded two probands affected with severe microcephaly (−15 SD and −12 SD) with the same homozygous indel from a single, consanguineous, Iranian family from a cohort of 404 predominantly Iranian families. The lack of heterozygous cases in two large cohorts representative of the genetic background of these two families decreased our suspicion of a founder allele and supports the contention of a recurrent mutation. We propose two potential secondary structure mutagenesis models for the origin of this variant allele mediated by hairpin formation between complementary GC rich segments flanking the stop codon via secondary structure mutagenesis.
Mosaic genome‐wide paternal uniparental disomy after discordant results from primary fetal samples and cultured cells
Authors: Mastromoro Gioia , Guadagnolo Daniele , Marchionni Enrica , Torres Barbara , Goldoni Marina , Onori Annamaria , Bernardini Laura , De Luca Alessandro , Torrente Isabella , Pizzuti Antonio 
Published: January 2023

AbstractMosaic genome‐wide paternal uniparental disomy (GWpUPD) is a rare condition in which two euploid cell lines coexist in the same individual, one with biparental content and one with genome‐wide paternal isodisomy. We report a complex prenatal diagnosis with discordant results from cultured and uncultured samples. A pregnant woman was referred for placental mesenchymal dysplasia and fetal omphalocele. Karyotype, array‐CGH and Beckwith‐Wiedemann Syndrome (BWS) testing (methylation‐specific multiplex ligation‐dependent probe amplification (MS‐MLPA) of 11p15) performed on amniocytes were negative. After intrauterine fetal demise, the clinical suspicion persisted and BWS MS‐MLPA was repeated on cultured cells from umbilical cord and amniotic fluid, revealing a mosaicism for KvH19 hypermethylation/KCNQ1OT1:TSS:DMR hypomethylation. These results, along with microsatellite analysis of the BWS region, were consistent with mosaic paternal 11p15 isodisomy. A concurrent maternal contamination exclusion test, analyzing polymorphic microsatellite markers on multiple chromosomes, showed an imbalance in favor of paternal alleles at all examined loci on cultured amniocytes and umbilical cord samples. This led to suspicion of mosaic GWpUPD, later confirmed by SNP‐array, identifying a mosaic genome‐wide paternal isodisomy affecting 60% of fetal cells. The assessment of mosaic GWpUPD requires multiple approaches beyond the current established diagnostic processes, also entertaining possible low‐rate mosaicism. Clinical acumen and an integrated testing approach are the key to a successful diagnosis.
Valorization of hemp fibers into biocomposites via one‐step pectin‐based green fabrication process
Authors: Both Avinash Kumar , Choudhry Deepa , Cheung Chin Li 
Published: January 2023

AbstractIn this paper, an environmentally friendly fabrication process was reported to valorize hemp fibers into biocomposites through a pectin‐based crosslinking reaction. In this water‐based chemical approach, the hemp fibers were crosslinked via a transesterification process between pectin and lignin present in hemp fibers to produce hemp fiber composites in a one‐step process. Our green process was advantageous over conventional processes that rely on the use of petroleum‐based organic solvents and high reaction temperatures because water was used as the reaction solvent with a mild reaction temperature (70°C). Additionally, to further optimize this biocomposite fabrication process, one‐factor analysis of variance study was carried out for investigating the main and interaction effects of the mass ratios of pectin to hemp fiber (1:5, 2:5, 3:5, 4:5, and 5:5) on the compressive strength and bulk density of the hemp fiber composite materials. In addition, the fabrication process was explored at different pH values to probe its versatility. The compressive strength of the as‐synthesized hemp fiber composite materials was observed to be dependent on the pH of the reaction conditions, indirectly confirming the formation of ester bonds between pectin and the lignin of hemp fibers via transesterification.
Preparation of cationic polyacrylate W/O crude oil emulsion demulsifier by free‐radical solution polymerization
Authors: Yuan Sisi , Wang Yongjun , Wang Xiujun , Liao Donghua , Duan Ming , Fang Shenwen 
Published: January 2023

AbstractThe block polyether demulsifier prepared by ring‐opening polymerization of ethylene oxide and propylene oxide under high temperature and high pressure is the most widely used demulsifier for water in crude oil emulsion. It has the high synthesis risk and cost. Therefore, the development of non‐block polyether demulsifier has attracted more and more attention. In this article, a new type of demulsifier was sythesized by radical polymerization of acrylate and cationic monomer. It was found that the copolymer PMA‐co‐PDBC of methyl acrylate (MA) and benzyldimethyl [2‐[(1‐oxoallyl)oxy] ethyl] ammonium chloride (DBC) synthesized in the mixed solvent of dipropylene glycol methyl ether and water had a good performance. When dosage of PMA‐co‐PDBC was 200 mg/L, the dehydration rate of water in crude oil emulsion with 50% water content can reach 80% at 80°C within 4 h. Structural and interface properties analysis presented that PMA‐co‐PDBC had a microblock structure similar with block polyether and it can effectively reduce the strength of W/O interfacial film to realize the demulsification. Although the demulsification performance of PMA‐co‐PDBC was not better than block polyether, its preparation safety and cost are much better. The results of this article can provide a new option for the development of crude oil demulsifier.
Preparation and drug release performance of amphiphilic medical hot‐melt pressure sensitive adhesives based on polystyrene‐isoprene‐styrene
Authors: Zhou Jing , Xu Yuhan , Guo Weihong 
Published: January 2023

AbstractHot‐melt pressure‐sensitive adhesives (HMPSAs) with polystyrene‐isoprene‐styrene (SIS) as the backbone material are widely used in transdermal drug delivery systems (TDDS) because of their high cohesive strength and drug‐carrying capacity. However, it is restricted by its high hydrophobicity when loaded with hydrophilic drugs. In this study, HMPSAs with amphiphilic properties were created by mixing SIS with fatty alcohol polyoxyethylene ether (AEO‐9) and polyethylene glycol (PEG) of different molecular weights to improve the ability of HMPSAs to deliver hydrophilic drugs. The effects of different molecular weights of PEG on the hydrophilicity of HMPSAs were also investigated. Additionally, gardenia glycosides and oleanolic acid were selected for drug release experiments. Compared to untreated HMPSAs, HMPSAs modified with AEO‐9 and PEG2000 could convert from hydrophobic to hydrophilic. The contact angle could be reduced from 91.8 to 25.6°, and the 24‐hour water absorption could be raised by 170%. The drug release experiments demonstrate that SIS/AEO‐9/PEG2000 enhances the release efficiency of the hydrophilic drug gardenia jasminoides by 69%. In summary, as a novel amphiphilic medicinal HMPSAs, SIS/AEO‐9/PEG offered a broad application promise in hydrophilic drug release.
Novel antistatic glass fiber reinforced heat‐resistant PA10T composites with excellent processing properties and thermal stability
Authors: Zhu Rongli , Pu Zejun , Hou Hongbo , Wang Xu , Li Xianyong , Yu Dayang , Zhong Jiachun , Song Ying 
Published: January 2023

AbstractIn this work, the antistatic effect of antistatic agent (AA) on semi‐aromatic poly (decamethylene terephthalamide) (PA10T) with 30 wt.% glass fiber (GF) was investigated. The PA10T/AGF antistatic composites with excellent thermal characteristics, balanced toughness, and notched impact strength were prepared through one‐step melt blending, and added the AA and GF to the PA10T matrix. Meanwhile, the structure, morphology, thermal properties, and mechanical properties were examined in detail by FT‐IR, SEM, TGA, DSC, and tensile and impulse testing. The results showed that the antistatic GF dispersed well in the PA10T matrix and interacted well with the PA10T matrix. The antistatic properties increased with the increase of AA content, and AA/GF‐5 composites had the best antistatic effect when AA content was 25 wt.%. However, with the increase of AA content, the melt temperature of PA10T/AGF composites decreased, while the machining performance and thermal stability of PA10T/AGF composites increased. The composites' tensile strength and breaking elongation followed a rising and falling pattern with increasing AA concentration. Notwithstanding, the notched impact strength of PA10T/AGF composites decreased and then increased. Therefore, this work provides us with a deep understanding of the antistatic effect of AA on polymers.