bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose tissue area is a predictive biomarker for the efficacy of pegylated liposomal doxorubicin in platinum‐refractory/resistant ovarian cancer
Authors: Yoshida Hiroyuki , Fujiwara Keiichi 
Published: May 2023

AbstractBackgroundPegylated liposomal doxorubicin (PLD), an anthracycline agent, is widely used as a treatment option for platinum‐refractory/resistant epithelial ovarian cancer (EOC). Although only a subset of patients with platinum‐refractory/resistant EOC derive benefit from PLD, predictive biomarkers for patients who will respond to the drug have not yet been established. Here, we evaluated the relationship between adipose tissue status and PLD efficacy in patients with platinum‐refractory/resistant EOC.MethodsPatients with platinum‐refractory/resistant EOC who were treated with single‐agent PLD were included in this retrospective cohort study. Adipose tissue areas including visceral adipose tissue area (VATA), subcutaneous adipose tissue area (SATA), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated prior to the initiation of PLD using computed tomography images. The associations of adipose tissue areas with objective response rate (ORR) and patient survival were evaluated.ResultsForty‐four patients with platinum‐refractory/resistant EOC who received single‐agent PLD were included. Subjects were categorized into high and low groups according to the median VATA, SATA, and VSR values, and body mass index (BMI). The ORR of PLD was significantly lower in the VSR‐high group than in the VSR‐low group (p = 0.0089). Patients in the high VSR group showed significantly shorter progression‐free survival (PFS) compared with patients in the low VSR group (median, 4.0 vs. 8.5 months; p = 0.020). In the multivariable analysis, high VSR was a significant prognostic factor for shorter PFS (hazard ratio, 2.07; 95% confidence interval, 1.05–4.19; p = 0.035). VATA, SATA, and BMI showed no significant association with ORR and survival of patients who received PLD.ConclusionsHigh VSR is associated with lower ORR and shorter PFS in patients with platinum‐refractory/resistant EOC who received single‐agent PLD. VSR is a robust predictive biomarker for the efficacy of PLD.
Enabling saccadic redirection through real‐time saccade prediction
Authors: Joshi Yashas , Poullis Charalambos (Charis) 
Published: May 2023

AbstractOur proposed redirected walking technique improves on current solutions by leveraging temporary visual disruption caused by saccades for redirection without requiring additional eye‐tracking hardware and enables saccadic redirection on widely used consumer‐grade hardware, like mobile VR. Using a deep neural network trained on head rotation data, we predict saccades during an apparent head rotation and apply rigid transformations to the virtual environment for redirection. This allows users to infinitely walk in a perceived straight direction from within a physical tracked space of m. The three user studies illustrated in this article validate our approach and demonstrate its efficacy.
Application of HSAB Theory in the Selective Reduction of Quinoline
Authors: Liu Tianwei , He Jianghua , Zhang Yuetao 
Published: May 2023

Comprehensive SummaryIt is very important to develop efficient synthetic strategies for site‐specific functionalization of tetrahydroquinolines due to their indispensable roles in pharmaceutical and agrochemical industries. We apply hard/soft acid/base (HSAB) theory to selective reduction of quinoline and achieve a series of C3‐functionalized tetrahydroquinoline in high to excellent yields (up to 99%) under mild conditions with the catalysis of B(C6F5)3. A series of in situ NMR reactions are also performed to investigate this cascade reaction. Moreover, AB type monomer 6‐(dimethylsilyl) quinoline and AA/BB type monomer 6,6'‐biquinoline are synthesized for polymer synthesis, which represents the first example of silicon bridged polytetrahydroquinoline.
An Experimental Exploration of C−H⋅⋅⋅X Hydrogen Bond in [CHCl3−X(CH3)2] Complexes (X=O, S, and Se)
Authors: Pal Dhritabrata , Charaya Heena , Chakraborty Shamik 
Published: May 2023

AbstractAmong the conglomeration of hydrogen bond donors, the C−H group is prevalent in chemistry and biology. In the present work, CHCl3has been selected as the hydrogen bond donor and are X(CH3)2are the hydrogen bond acceptors. Formation of C−H⋅⋅⋅X hydrogen bond under the matrix isolation condition is confirmed by the observation of red‐shift in the C−H stretching frequency of CHCl3and comparison with the simulated spectra. Stabilisation energy of all the three complexes is almost equal although the observed red‐shift for the C−H⋅⋅⋅O complex is less compared to the C−H⋅⋅⋅S/Se complexes. The nature and origin of the hydrogen bond have been delineated using Natural Bond Orbital, Atoms in Molecules, Non‐Covalent Interaction analyses, and Energy Decomposition Analysis. Charge transfer is found to be proportional to the observed red‐shift. This work provides the first impression of C−H⋅⋅⋅Se hydrogen bond and its comparison with C−H⋅⋅⋅O/S hydrogen bond interaction under experimental condition.
Salivary trefoil factor family peptide 3 (TFF3) and flow rate in persons with and without obstructive sleep apnea: A preliminary study
Authors: Ruangsri Supanigar , Doolgindachbaporn Gintawat , Chokwatwikul Worrapon , Wattanawareekul Kanchanaporn , Puasiri Subin , Sawanyawisuth Kittisak 
Published: May 2023

AbstractObjectivesObstructive sleep apnea (OSA) is one of the most common chronic diseases. Trefoil factor family 3 (TFF3) peptides are secreted by major and minor salivary glands and may be involved in the pathogenesis of OSA. This study aimed to evaluate salivary TFF3 and flow rate between those with and without OSA.Material and methodsThis was a prospective experimental study that enrolled patients with OSA and non‐OSA. Total unstimulated saliva was collected, the salivary flow rate was measured, and the TFF3 level was analyzed by using a modified sandwich enzyme‐linked immunosorbent assay. Baseline characteristics, TFF3 level, and salivary flow rate were compared between both groups. Factors associated with the TFF3 level and flow rate were computed by using multivariate linear regression analysis.ResultsTwenty‐eight participants were recruited in the study: 20 patients with OSA (71.42%) and 8 non‐OSA as control. The TFF3 and salivary flow rates between both groups of non‐OSA versus OSA were comparable (TFF3 non‐OSA 61.06 vs. OSA 96.00 ng/mg; p = .276 and flow rate non‐OSA 0.40 vs. OSA 0.35 mL/min; p = .320). Factors associated with the TFF3 level were neck circumference with a negative coefficient of −16.419 (p =  .042). For the salivary flow rate, only age was a significant factor with the coefficient of −0.013 (p = .044).ConclusionsTFF3 and salivary flow rate were comparable between patients with OSA and non‐OSA. The factor associated with TFF3 level was neck circumference, while age was negatively associated with the salivary flow rate in patients with OSA.
Managing Soil Acidity, Not Soil Balancing, Affects Yield
Authors: Sever Megan 
Published: May 2023

AbstractIt can be hard to convince people of something when they think their lived experience suggests otherwise. That’s the challenge facing scientists trying to convince organic farmers that soil balancing—specifically through the base cation saturation ratio method—doesn’t actually improve crop yield. New research echoes previous work showing crop yields are affected by pH but not the calcium‐magnesium ratio soil balancing. Earn 0.5 CEUs in Soil & Water Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
Definitions and criteria for diabetes‐related foot disease (IWGDF 2023 update)
Authors: van Netten Jaap J. , Bus Sicco A. , Apelqvist Jan , Chen Pam , Chuter Vivienne , Fitridge Robert , Game Frances , Hinchliffe Robert J. , Lazzarini Peter A. , Mills Joseph , Monteiro‐Soares Matilde , Peters Edgar J. G. , Raspovic Katherine M. , Senneville Eric , Wukich Dane K. , Schaper Nicolaas C. ,   International Working Group on the Diabetic Foot
Published: May 2023

AbstractMultiple disciplines are involved in the management of diabetes‐related foot disease and a common vocabulary is essential for clear communication. Based on the systematic reviews of the literature that form the basis of the International Working Group on the Diabetic Foot (IWGDF) Guidelines, the IWGDF has developed a set of definitions and criteria for diabetes‐related foot disease. This document describes the 2023 update of these definitions and criteria. We suggest these definitions be used consistently in both clinical practice and research, to facilitate clear communication with people with diabetes‐related foot disease and between professionals around the world.
Probiotics, prebiotics, and synbiotics in type 1 diabetes mellitus: A systematic review and meta‐analysis of clinical trials
Authors: Moravejolahkami Amir Reza , Shakibaei Mehdi , Fairley Andrea Mary , Sharma Manoj 
Published: May 2023

AbstractDysbiosis or imbalance of microbes in the gut has been associated with susceptibility and progression of type 1 diabetes mellitus (T1DM). The present systematic review and meta‐analysis examined the effects of probiotics, prebiotics, and synbiotics on fasting blood glucose (FBG), haemoglobin A1c (HbA1c), C‐peptide, and insulin requirements in T1DM patients. A systematic search for trials published up to October 2022 was conducted in PubMed, EMBASE, Scopus, Google Scholar, ScienceDirect, Web of Science, and the Central Cochrane Library. Random effect models were used to synthesise quantitative data by STATA14. After the evaluation of 258 identified entries, five randomised controlled trials (n = 356; mean age = 11.7 years old) were included. The pooled effect size showed that FBG decreased following probiotic supplementation (weighted mean difference = −31.24 mg/dL; 95% confidence interval = −45.65, −16.83; p < 0.001), however, there was no significant improvement in serum HbA1c, C‐peptide, and insulin requirements. Probiotic supplementation could be a complementary therapeutic strategy in T1DM. The evidence is limited; therefore, it is crucial to conduct more trials.
Modeling the drivers of eutrophication in Finland with a machine learning approach
Authors: Heikonen Sara , Yli‐Heikkilä Maria , Heino Matias 
Published: May 2023

AbstractAnthropogenic eutrophication is one of the most common threats to inland water quality, often causing toxic algal blooms and loss of aquatic biodiversity. Mitigating the harmful impacts of eutrophication requires managing nutrient inputs from the catchment focusing on the major local drivers of eutrophication. These drivers can be identified using models that predict lake trophic state based on characteristics of the lake and its catchment. In this study, we aimed to extend the spatial scope of these models by identifying drivers of eutrophication in a large sample of lakes (1547) distributed across Finland. Moreover, we used satellite‐observed chlorophyll a (chl a) concentration as trophic state indicator, instead of site‐sampled data, which is commonly used in existing research. We identified major drivers of eutrophication on river basin district to country scale based on 11 catchment and lake characteristics, applying the random forest algorithm. On country scale, the catchment and lake characteristics explained 41% of the variation in lake chl a concentrations, and on river basin district scale, 20%–44%. Catchment and lake hydromorphology were the most important explanatory characteristics. Especially, high natural eutrophication level, shallow mean depth of lake, and small share of lake area in the catchment were related to increased lake chl a concentration. Moreover, depending on the dominant land use type in the model area, share of agricultural area and share of peatland area in the catchment were ranked among the most important drivers of increased lake chl a concentration. The results suggest that trophic state predictive models utilizing satellite‐observed chl a concentration could provide an additional, cost‐effective tool for addressing lake eutrophication, especially in areas without and extensive on‐site monitoring network.
The impact of ice storms on mycorrhizal fungi varies by season and mycorrhizal type in a hardwood forest
Authors: Yancey C. E. , Juice S. M. , Classen A. T. , Rustad L. , Adair E. Carol 
Published: May 2023

AbstractExtreme weather events, such as ice storms, are increasing and have potentially large impacts on forests, including belowground structures such as fine roots and mycorrhizal fungi. Many forest trees rely on the mutualistic relationship between mycorrhizal fungi and plants; a relationship that, when disrupted, can negatively impact tree net primary productivity. We took advantage of a large‐scale ice storm manipulation in the northeastern United States to test the hypothesis that increasing ice storm intensity and frequency would reduce ectomycorrhizal fungal root tips per unit root length and arbuscular mycorrhizal fungal structures per unit root length, hereafter colonization. We found that ice storm intensity reduced spring ectomycorrhizal fungal and arbuscular mycorrhizal fungal colonization. However, these patterns changed in the fall, where ice storm intensity still reduced ectomycorrhizal fungal root tips, but arbuscular mycorrhizal fungal colonization was higher in ice storm treatments than controls. The amount of ectomycorrhizal fungal root tips and arbuscular mycorrhizal fungal colonization differed seasonally: ectomycorrhizal fungal root tips were 1.7× higher in the spring than in the fall, while arbuscular mycorrhizal fungal colonization was 3× higher in the fall than in the spring. Our results indicate that mycorrhizal fungal colonization responses to ice storm severity vary temporally and by mycorrhizal fungal type. Further, arbuscular mycorrhizal fungi may recover from ice storms relatively quickly, potentially aiding forests in their recovery, whereas ice storms may have a long lasting impact on ectomycorrhizal fungi.
Recent advances and opportunities related to the use of bee products in food processing
Authors: Kieliszek Marek , Piwowarek Kamil , Kot Anna M. , Wojtczuk Marta , Roszko Marek , Bryła Marcin , Trajkovska Petkoska Anka 
Published: May 2023

AbstractNowadays, natural foods that can provide positive health effects are gaining more and more popularity. Bees and the products they produce are our common natural heritage that should be developed. In the article, we presented the characteristics of bee products and their use in industry. We described the development and importance of beekeeping in the modern world. Due to their high nutritional value and therapeutic properties, bee products are of great interest and their consumption is constantly growing. The basis for the use of bee products in human nutrition is their properties and unique chemical composition. The conducted research and opinions confirm the beneficial effect of bee products on health. The current consumer awareness of the positive impact of food having a pro‐health effect on health and well‐being affects the increase in interest and demand for this type of food among various social groups. Enriching the daily diet with bee products may support the functioning of the organism. New technologies have appeared on the market to improve the process of obtaining bee products. The use of bee products plays a large role in many industries; moreover, the consumption of bee products and promotion of their medicinal properties are very important in shaping proper eating habits.
Impact of FIGO type 3 uterine fibroids on in vitro fertilization outcomes: A systematic review and meta‐analysis
Authors: Favilli Alessandro , Etrusco Andrea , Chiantera Vito , Laganà Antonio Simone , Cicinelli Ettore , Gerli Sandro , Vitagliano Amerigo 
Published: May 2023

AbstractBackgroundThe effect of FIGO (the International Federation of Gynecology & Obstetrics) type 3 myomas on in vitro fertilization (IVF) is uncertain.ObjectivesTo evaluate whether FIGO type 3 myomas affect IVF outcomes, through a systematic review and meta‐analysis (CRD42022379700).Search strategyElectronic databases were searched until November 15, 2022.Selection criteriaStudies evaluating the effects of FIGO type 3 myomas on IVF outcome.Data collection and analysisPooled results were expressed as odds ratios (OR) with 95% confidence intervals (CI). Heterogeneity was assessed using Higgins I2. Sources of heterogeneity were explored with sensitivity and subgroup analyses.Main resultsIn total, 1020 patients were included: 324 with FIGO type 3 myomas and 696 controls (without myomas). A pooled data analysis showed a significantly lower live birth rate (OR 2.16, 95% CI 1.55–3.01, I2 = 0%, P < 0.00001), clinical pregnancy rate (OR 2.06, 95% CI 1.52–2.81, I2 = 0%, P < 0.00001), and implantation rate (OR 1.77, 95% CI 1.35–2.32, I2 = 0%, P < 0.00001) in women with untreated myomas compared with controls. The number and size of fibroids correlated with a worsening of IVF outcomes.ConclusionsFIGO type 3 myomas are significantly associated with a lower implantation rate, cumulative pregnancy rate, and live birth rate. Furthermore, their deleterious effect on the outcome of IVF increases further with increasing size and number. Nevertheless, no firm conclusions could be drawn about the potential benefits of surgery for FIGO type 3 uterine fibroids on IVF outcomes.
Assessment of abnormal placentation in pregnancies conceived with assisted reproductive technology
Authors: Violette Caroline J. , Mandelbaum Rachel S. , Matsuzaki Shinya , Ouzounian Joseph G. , Paulson Richard J. , Matsuo Koji 
Published: May 2023

AbstractObjectiveTo examine the association between assisted reproductive technology (ART) and abnormal placentation.MethodsThis is a retrospective cohort study querying the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample. The study population included 14, 970, 064 deliveries for national estimates from January 2012 to September 2015. The exposure was 48, 240 pregnancies after ART. The main outcome measure encompassed three abnormal placentation pathologies (placenta previa [PP], placenta accreta spectrum [PAS], and vasa previa [VP]). Propensity score matching was performed to assess the exposure‐outcome association.ResultsPregnancy after ART was more likely to have a diagnosis of PAS (2.8 vs 1.0 per 1000 deliveries; adjusted odds ratio [aOR], 2.06 [95% confidence interval (CI), 1.44–2.93]), PP (24.5 vs 8.6 per 1000; aOR, 2.98 [95% CI, 2.64–3.35]), and VP (2.3 vs <0.3 per 1000; aOR, 11.3 [95% CI, 5.86–21.8]) compared with pregnancy without ART. Similarly, pregnancy after ART was associated with an increased likelihood of having multiple types of abnormal placentation, including VP with PP (aOR, 15.4 [95% CI, 6.15–38.4]) and PAS with PP (aOR, 2.80 [95% CI, 1.32–5.92]) compared with non‐ART pregnancy.ConclusionsThis national‐level analysis suggests that pregnancy after ART is associated with a significantly increased risk of abnormal placentation, including PAS, PP, and VP.
A case of complete resection of prostate stromal sarcoma after neoadjuvant chemotherapy
Authors: Hodotsuka Naoto , Suzuki Yasutomo , Suzuki Kyota , Honda Yuichiro , Endo Shuma , Kuribayashi Eigo , Obayashi Kotaro , Minowa Tadaaki , Hatori Tsutomu , Kondo Yukihiro 
Published: May 2023

IntroductionProstatic stromal sarcoma is an extremely rare malignancy of the prostate with a poor prognosis.Case presentationA 65‐year‐old man presented with dyschezia, and computed tomography showed a large prostate mass. The diagnosis was prostate stromal sarcoma by transrectal needle biopsy. Magnetic resonance imaging suggested rectal infiltration. The patient underwent 4 courses of neoadjuvant chemotherapy with gemcitabine and docetaxel hydrate followed by total pelvic exenteration.ConclusionNo recurrence has occurred at 5 years after the surgery. This is the first report of complete resection in prostate stromal sarcoma after neoadjuvant chemotherapy with gemcitabine and docetaxel hydrate.
Mechanism of action and therapeutic potential of dimethyl fumarate in ischemic stroke
Authors: Owjfard Maryam , Karimi Farzaneh , Mallahzadeh Arashk , Nabavizadeh Seyed Ali , Namavar Mohammad Reza , Saadi Mahdiyar Iravani , Hooshmandi Etrat , Salehi Mohammad Saied , Zafarmand Seyedeh Shaghayegh , Bayat Mahnaz , Karimlou Sedigheh , Borhani‐Haghighi Afshin 
Published: May 2023

AbstractDimethyl fumarate (DMF) is an immunomodulatory drug currently approved for the treatment of multiple sclerosis and psoriasis. Its benefits on ischemic stroke outcomes have recently come to attention. To date, only tissue plasminogen activators (tPAs) and clot retrieval methods have been approved by the FDA for the treatment of ischemic stroke. Ischemic conditions lead to inflammation through diverse mechanisms, and recanalization can worsen the state. DMF and the nuclear factor erythroid‐derived 2‐related factor 2 (Nrf2) pathway it regulates seem to be important in postischemic inflammation, and animal studies have demonstrated that the drug improves overall stroke outcomes. Although the exact mechanism is still unknown, studies indicate that these beneficial impacts are due to the modulation of immune responses, blood–brain barrier permeability, and hemodynamic adjustments. One major component evaluated before, during, and after tPA therapy in stroke patients is blood pressure (BP). Recent studies have found that DMF may impact BP. Both hypotension and hypertension need correction before treatment, which may delay the appropriate intervention. Since BP management is crucial in managing stroke patients, it is important to consider DMF's role in this matter. That being said, it seems further investigations on DMF may lead to an alternative approach for stroke patients. In this article, we discuss the mechanistic roles of DMF and its potential role in stroke based on previously published literature and laboratory findings.
Novel protocol for optimal utilization of HPSD approach for pulmonary vein isolation
Authors: Manukyan Hayarpi , Szegedi Nandor , Pavlović Nikola , Blessberger Herman , Fiedler Lucas , Krieger Konstantin , Manola Šime , Nagy Vivien K. , Roithinger Franz Xaver , Salló Zoltán , Steinwender Clemens , Gellér László , Matschuck Guido A. , Kosiuk Jedrzej 
Published: May 2023

AbstractBackgroundThe efficiency of pulmonary vein isolation (PVI) depends on the durability of RF lesions. Recent studies documented sustained continuity of ablation lines, improvements in durability, and expected clinical outcomes through altered settings in duration and power. However, the ablation strategy has not been adapted to this new approach and different biophysics of lesion formation.PurposeThe aim of this study was to demonstrate that by adjusting the ablation approach to the broader geometry of lesions by increasing the minimal spacing between adjacent RF, a further significant reduction of procedural time while maintaining sufficient long‐term outcomes is achievable.MethodsThe presented study was a prospective, observational multi‐center trial. The periprocedural data were compared with data from a consecutively collected historical cohort.ResultsIn total, 196 patients were included (mean age 62 ± 11 years, male 64.3%). Procedural duration, RF time, and LA dwelling time were significantly shorter in the HPSD group compared with the standard group (73 ± 26 min vs. 98 ± 36 min, p < .001; 14 ± 7 min vs. 33 ± 12 min, p < .001; and 59 ± 21 min vs. 77 ± 32 min, p < .001, respectively). Mean AF‐free survival in the first year of follow‐up was 304 ± 14 days in the HPSD group versus 340 ± 10 days in the standard group (log‐rank p = .403). There were no statistically significant differences in the complication rates between the groups.ConclusionIncreasing the minimal distance between individual application points simplifies AF ablation and further reduces procedure time without negative effects on efficacy and safety. Larger studies are needed to optimally utilize this approach.