bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Yuridis Bagi Pelaku Narkotika yang Jenis Narkobanya Tidak Terdaftar dalam Undang-Undang Narkotika
Authors: Delyanti Sri , Ablisar Madiasa , Mulyadi Mahmud , Ekaputra Mohammad 
Published: July 2023

Pasal 6 Undang-Undang Nomor 35 Tahun 2009 Tentang Narkotika, Walaupun dikemudian hari tiap pembuktian di persidangan harus didatangkan ahli untuk menentukan suatu jenis zat tertentu apakah masuk ke dalam pengertian Narkotika menurut Undang-Undang Nomor 35 Tahun 2009 Tentang Narkotika. Tapi hal itu perlu untuk mencegah setiap Tindak Pidana Narkotika jenis baru lolos dari jerat hukum, namun dengan tetap menjaga kepastian hukum. Metode penelitian yang digunakan yaitu yuridis normatif. Hasil penelitian menunjukkan bahwa Penegakan hukum pidana terhadap penyalahgunaan methylone sebagai NPS (New Psychoactive Substances) mewajibkan para penegak hukum melakukan penemuan hukum lewat jalan penafsiran hukum yang dilakukan secara ekstensif yang dilakukan dengan cara memperluas makna zat methylone dan methcathinone merupakan turunan dari cathinone yang terdapat dalam daftar narkotika golongan I, dimana struktur dasar dari methylone adalah analog dengan methylone dengan efek farmakologi juga menyerupai methylone, namun methylone mempunyai efek yang dihasilkan jauh lebih dahsyat dan lebih merusak susunan syaraf pusat dibanding senyawa methylone sehingga tidak diragukan lagi bahwa methylone adalah termasuk narkotika golongan I dalam lampiran I UU Nomor 35 Tahun 2009 Tentang Narkotika No. Urut 37.
fomento de la educación socioemocional en alumnos de primer grado
Authors: Arán Sánchez Ana 
Published: July 2023

Actualmente, el desarrollo de las habilidades relacionadas con la identificación y el manejo de las emociones en el alumnado se considera una prioridad en el sistema educativo, debido a los diferentes estudios que plantean la relación entre el fortalecimiento de estos aspectos y el desempeño académico, así como la cualidad de fungir como factores de protección frente a futuros problemas emocionales. La presente investigación muestra los resultados de un programa implementado en primero de primaria en una comunidad rural del estado de Chihuahua, centrado en el desarrollo de tres competencias socioemocionales: autoestima, autorregulación y empatía. De acuerdo al diagnóstico realizado a través de una guía de observación basada en el plan de estudios 2017, se diseñó e implementó un cronograma de intervención durante los primeros meses del ciclo escolar 2019-2020, con diversas estrategias y acciones para fortalecer estas habilidades en los estudiantes. El documento se enmarca en el paradigma Socio-crítico, con un enfoque cualitativo y la metodología de Investigación Acción del Profesor (IAP). Los resultados muestran la importancia de fortalecer el aspecto socioemocional desde el inicio de la educación básica, ya que favorece la convivencia grupal y un desarrollo integral en el alumno.
Recepción: 20/12/2022. Aceptación: 5/3/2023. Publicación: 27/6/2023
sueño de la razón
Authors: Molinari Leticia 
Published: July 2023

En esta propuesta, abordaremos dos obras homónimas, El sueño de la razón produce monstruos, ancladas en entornos distantes temporal y espacialmente: un grabado del artista español Francisco de Goya y Lucientes de fines del siglo XVIII y una pieza electroacústica del compositor argentino Ricardo de Armas de comienzos del siglo XXI. La obra sonora se inspira en el grabado y este es el punto de partida para un análisis entre ambas producciones en el cual aplicaremos principalmente el concepto de migración y sus niveles como herramienta metodológica desarrollada por la Dra. Cintia Cristiá.
Recepción: 16/12/2023. Aceptación: 25/4/2023. Publicación: 27/6/2023
Association of Glycosylated Albumin Level with Gestational Diabetes Mellitus
Authors: Islam Fahmida , Kazal Rezaul Karim , Haque Nadira , Hosain Nazmul , Rumi Badrunnahar , Debnath Keya , Akter Ruma , Begum Marjia , Akhter Farhana 
Published: July 2023

Background: Gestational Diabetes Mellitus (GDM) is a common medical disorder detected during pregnancy with adverse consequences on the health of the mother and the fetus. Glycosylated hemoglobin (HbA1c) is an important parameter of glycemic control in patients with diabetes mellitus. However, it only reflects the long-term glycemic status, but can’t reflect short term glycemic control. It has also been demonstrated that HbA1c does not reflect glycemic control accurately during pregnancy because of iron deficiency. But Glycosylated Albumin (GA) reflects average blood glucose within 2-3 weeks and is not influenced by iron deficiency. Therefore, glycosylated albumin may be used to measure recent changes in blood glucose level in GDM patients. The aim of the study is to evaluate the association of glycosylated albumin and glycemic status in GDM.
Materials and methods: This case control study was carried out in the Department of Obstetrics & Gynecology, Bangabandhu Sheikh Mujib Medical University, BSMMU, Dhaka between August 2017 and December 2018. Atotal of 140 pregnant women between 18-35 years of age attending outdoor antenatal clinic in their second and third trimester of pregnancy were enrolled in this study. Among them 70 diagnosed case of GDM were considered as group I and rest 70 non-diabetic pregnant women were considered as control and group II. Plasma glycosylated albumin was measured in all of these patients. Statistical analysis of the results was obtained by using Windows based computer software devised with Statistical Packages for Social Sciences (SPSS-22).
Results: The mean glycosylated albumin was 17.12±2.00 (%) in group I and 12.90±1.03 (%) in group II. The difference was statistically significant (p<0.05) between two groups. There was a positive significant moderate correlation (r=0.643, p=0.001) between glycosylated albumin (%) and 2 hours after 75 gm glucose in GDM patients. There was also a positive significant weak correlation (r=0.258, p=0.031) between GA and FBS in GDM patients.
Conclusion: A significant positive association was found between glycemic status in GDM and maternal glycosylated albumin levels. Therefore,glycosylated albumin may be applied to reflect the average blood glucose status in pregnant women with GDM.
JCMCTA 2021 ; 32 (2) : 64-69
Clinical Presentation, Management and Outcome of Gestational Trophoblastic Diseases Admitted in Chittagong Medical College Hospital
Authors: Jafrin Nilima , Chowdhury Shahanara , Mozumder Md Myen Uddin , Akter Shahin , Sultana Nasrin , Sharif S M Shalauddin , Barua Debjane 
Published: July 2023

Background: Gestational Trophoblastic Disease (GTD) is a heterogeneous group of diseases that includes partial and complete hydatidiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumour. The study aimed to determine the clinical presentation management options and outcome of GTD in patients admitted in a tertiary hospital of Bangladesh.
Materials and methods: This prospective observational study included 50 patients with GTD from the Obstetrics and Gynaecology Department of Chittagong Medical College Hospital, during the period of July 2013 to December 2013. The demographic profile, clinical presentation, management, outcome and complications were studied.
Results: Mean age was 25.40 ± 8.34 years with most of the patients (46%) were in age group 20 - 29 years. 42% participants were primigravida. The commonest symptom after bleeding per-vaginum (94%) was amenorrhea (90%). Maximum cases (80%) were of complete hydatidiform mole. Rate of progression to invasive mole and choriocarcinoma were found 6% and 10% respectively. Suction evacuation and hysterectomy were the treatment option. One patient (2%) expired due to excessive bleeding.
Conclusion: The majority of cases are cured by simple suction uterine curettage. Regular follow up is important to estimate the true incidence of this disease.
JCMCTA 2021 ; 32 (2) : 128-131
Fetus-in-Fetu: A Rare Entity
Authors: Clump Justin , Quadir Shabiha , Chowdhury Kakoli , Uddin Kazi Mohammad Moin 
Published: July 2023

Background : Fetus in fetu is a rare congenital anomaly in which a malformed fetus or parasitic fetus grows within the body of its twin. It is a parasitic twin of a Diamniotic, monozygotic twin. Fetus in fetu is often overlooked in the differential diagnosis of an abdominal mass in infants and children. Teratoma is one of the closest differentials and must be excluded. Unlike teratomas, fetus in fetu is a benign disorder. The objective of our study is to describe the sonographic findings of an extremely rare pathology. We therefore the present diagnosis, pathology, management of fetus-in-fetu.
Case Presentation: On 6th June 2021, a two years boy was brought by his parents to Chittagong Medical College Hospital (CMCH) for treatment with the complains of abdominal mass, occasional abdominal pain and loss of appetite. The patient was evaluated radiologically by plain radiographs, USG and pre & post contrast CT scan of the abdomen. All radiological modalities showed a mass in the left lumber region having internal bony structures likelong bone, vertebra and teeth. CT scan played the vital role in clearly demonstrating the bones and confirming the presence of vertebra. Radiologically a diagnosis was made as fetus-in-fetu and the possibility of Teratoma was excluded by the presence of vertebra. The patient underwent surgery and the mass was completely excised. A deformed parasitic fetus enclosed in a complete capsule was removed from the patient’s abdominal cavity. Autopsy of the specimen showed deformed limbs, presence of vertebra, long bone, other soft tissue, organogenesis around an axis and histopathology confirmed the presence of vertebra, bone and bone marrow, cardiac muscle, nerve tissue, intestine, renal tubules with glomerulus, lymphoid tissue, respiratory epithelium and skin. All findings were compatible with fetus-in-fetu.
Conclusion : Although fetus in fetu is a rare condition, correct diagnosis using imaging can be made before surgery. It should be considered as a diffential diagnosis for lump abdomen especially in infant. Complete excision is curative.
JCMCTA 2021 ; 32 (2) : 151-155
Cardiovascular Risk Factors among Patients with Systemic Lupus Erythematosus Presented in a Tertiary Care Hospital
Authors: Hassan Hamid , Ali Mohammad Shawkat , Islam Md Asiful , Chowdhury Abu Taiub Mohammed Mohiuddin 
Published: July 2023

Background: Risk factors for cardiovascular disease are particular habits, behaviors, circumstances or conditions that increase a person's risk of developing cardiovascular disease, including lack of exercise, unhealthy eating, smoking, diabetes, age and family history. Cardiovascular risk factors were observed and compared to find out their contribution among patients with SLE.
Materials and methods: In this case control study, consecutive patients with SLE attending the Department of Medicine Dhaka Medical College Hospital (DMCH) were studied. The control population was recruited from subjects attending the other departments of the hospital and healthy attendants. The prevalence of classic Framingham cardiovascular risk factors, lipid profile, other metabolic risk factors, lifestyle variables, and demographic characteristics were compared between the 2 groups.
Results: 80 SLE patients and 80 age and sex matched controls were studied. Patients with SLE had significantly high BMI and waist circumference (p_0.012 and p_0.001 respectively). Hypertension, diabetes were significantly more common among the SLE patients (31.29% versus 11.25%, p_0.023 and 13.75% versus 3.75, p_0.03). In comparison with control, patients with SLE had no significant difference in mean total cholesterol (193.92±23.65 versus 183.66±11.39, p_0.41) and triglyceride (174.77±60.06 versus 149.15±28.68, p_0.11), but had significantly higher low density lipoprotein (120.77±16.07 versus 108.17±11.68, p_0.00) and lower high-density lipoprotein cholesterol (41.37±4.52 versus 43.51±3.34, p_0.00).
Conclusion: Patients with SLE have a range of detectable and significant cardiovascular risk factors.
JCMCTA 2022 ; 33 (1) : 160-165
Perbedaan Efek Madu Akasia dengan Madu Multiflora terhadap Peningkatan Kadar Hemoglobin Remaja Putri
Authors: Rahayu Rejeki Ratri , Widowati Retno , Dahlan Febry Mutiariami 
Published: July 2023

Anemia remaja putri karena defisiensi zat besi mengakibatkan menurunnya prestasi belajar. Dibutuhkan asupan makanan tinggi zat besi seperti sayuran, protein hewani, protein nabati dan madu. Madu diketahui mengandung nutrisi yang lengkap dan dapat mengatasi anemia. Tujuan: Mengetahui perbedaan pemberian madu Akasia dan madu Multiflora terhadap peningkatan kadar hemoglobin remaja putri. Metode: Desain penelitian quasi eksperimen dengan pre test dan post test dengan grup kontrol. Penelitian pada bulan November 2022 – Januari 2023 di Posyandu remaja dengan populasi 49 remaja putri yang menderita anemia. Sampel dengan teknik purposive sampling berjumlah 40 orang. Kelompok intervensi akan diberikan madu Akasia dan pada kelompok kontrol diberikan madu Multiflora selama 14 hari dengan dosis 2x10 ml dan tetap minum tablet tambah darah 1x seminggu. Hasil: Rerata kadar hemoglobin sebelum dan sesudah pemberian madu Aksia sebesar 11,5 mg/dl dan 12,46 mg/dl. Rerata kadar hemoglobin sebelum dan sesudah pemberian madu Multiflora sebesar 11,39 mg/dl dan 12,46 mg/dl. Hasil uji Mann Whitney untuk melihat perbedaan didapatkan p value 0,567 > 0,05, sehingga tidak ada perbedaan kenaikan kadar hemoglobin pada remaja putri sesudah pemberian madu Akasia dan madu Multiflora. Kesimpulan : Tidak ada perbedaan kenaikan kadar hemoglobin pada madu Akasia dan Multiflora, keduanya memiliki pengaruh signifikan untuk menaikkan kadar hemoglobin.
Utilization of multiple genetic methods for prenatal diagnosis of rare thalassemia variants
Authors: Jiang Fan , Zhou Jianying , Zuo Liandong , Tang Xuewei , Li Jian , Li Fatao , Yang Tianhe , Qu Yanxia , Wan Junhui , Liao Can , Li Dongzhi 
Published: July 2023

Background: Thalassemia is the most prevalent monogenic disorder caused by an imbalance between the α- and β-globin chains as a result of pathogenic variants in the α- or β-globin genes. Novel or complex structural changes in globin genes are major hurdles for genetic consulting and prenatal diagnosis.Methods: From 2020 to 2022, genetic analysis was performed on 1,316 families suspected of having children with thalassemia major, including 42 pregnant couples suspected of being thalassemia carriers with rare variants. Multiple techniques including multiplex ligation-dependent probe amplification (MLPA), Sanger sequencing, targeted next-generation sequencing, and single-molecule real-time (SMRT) sequencing were used to diagnose rare thalassemia.Results: The rate of prenatal diagnosis for rare thalassemia variants was 3.19% (42/1,316). The most prevalent alleles of α- and β-thalassemia are Chinese Gγ(Aγδβ)0and -- THAI deletion. In addition, ten rare complex genotypes include one Chinese Gγ(Aγδβ)0 deletion combined with HBG1-HBG2 fusion, two rare deletions at HBB gene (hg38, Chr11: 5224211-5232470, hg38, Chr11: 5224303-5227790), one complete 7,412 bp fusion gene for anti-Lepore Hong Kong, two complex rearrangements of the α-globin gene cluster, two novel duplications, and two rare large deletions in the α-globin gene cluster.Conclusion: Accurate gene diagnosis for probands with combined molecular biology techniques is the key to prenatal diagnosis of rare thalassemia.
Bacterial outer-membrane vesicles promote Vγ9Vδ2 T cell oncolytic activity
Authors: Firth Jack , Sun Jingjing , George Vaques , Huang Jian-Dong , Bajaj-Elliott Mona , Gustafsson Kenth 
Published: July 2023

BackgroundIncreasing evidence suggests the immune activation elicited by bacterial outer-membrane vesicles (OMVs) can initiate a potent anti-tumor immunity, facilitating the recognition and destruction of malignant cells. At present the pathways underlying this response remain poorly understood, though a role for innate-like cells such as γδ T cells has been suggested.MethodsPeripheral blood mononuclear cells (PBMCs) from healthy donors were co-cultured with E. coli MG1655 Δpal ΔlpxM OMVs and corresponding immune activation studied by cell marker expression and cytokine production. OMV-activated γδ T cells were co-cultured with cancer cell lines to determine cytotoxicity.ResultsThe vesicles induced a broad inflammatory response with γδ T cells observed as the predominant cell type to proliferate post-OMV challenge. Notably, the majority of γδ T cells were of the Vγ9Vδ2 type, known to respond to both bacterial metabolites and stress markers present on tumor cells. We observed robust cytolytic activity of Vγ9Vδ2 T cells against both breast and leukaemia cell lines (SkBr3 and Nalm6 respectively) after OMV-mediated expansion.ConclusionsOur findings identify for the first time, that OMV-challenge stimulates the expansion of Vγ9Vδ2 T cells which subsequently present anti-tumor capabilities. We propose that OMV-mediated immune activation leverages the anti-microbial/anti-tumor capacity of Vγ9Vδ2 T cells, an axis amenable for improved future therapeutics.
Reduced cingulate gyrus volume in Cavalier King Charles Spaniels with syringomyelia and neuropathic pain revealed by voxel-based morphometry: a pilot study
Authors: Nitzsche Björn , Schulze Sabine , Boltze Johannes , Schmidt Martin J. 
Published: July 2023

ObjectivePathomorphological alterations of the central nervous system in dogs, such as syringomyelia and Chiari-like malformation, can cause cranial and cervical hyperesthesia and neuropathic pain. The long-term activity of the pain network can induce functional alteration and eventually even morphological changes in the pain network. This may happen especially in the prefrontal and cingulate cortex, where atrophy of the gray matter (GM) was observed in humans with chronic pain, irrespective of the nature of the pain syndrome. We tested the hypothesis that Cavalier King Charles Spaniels (CKCS) with Chiari-like malformation and associated syringomyelia (SM) and pain show cerebral morphological differences compared to animals without signs of syringomyelia and pain.MethodsVolumetric datasets of 28 different brain structures were analyzed in a retrospective manner, including voxel-based morphometry, using magnetic resonance imaging data obtained from 41 dogs.ResultsVolumetric analyses revealed a decrease in GM volumes in the cingulate gyrus (CG) in CKCS with SM and chronic pain when normalized to brain volume. This finding was supported by voxel-based morphometry, which showed a cluster of significance within the CG.ConclusionGM atrophy in the CG is associated with chronic pain and thus may serve as an objective readout parameter for the diagnosis or treatment of canine pain syndromes.
Assessment of disease severity and patient prognosis in anti-GABABR encephalitis with and without comorbid tumors
Authors: Gao Caiyun , Chen Zhongyun , Huang Huijin , Zhu Runxiu , Su Yingying 
Published: July 2023

PurposeThis study aimed to analyze the severity of the condition and prognosis of patients with anti-gamma-aminobutyric-acid type B receptor (anti-GABABR) encephalitis with tumors.MethodsPatients with anti-GABABR encephalitis admitted to one of two hospitals from 2020 to 2022 were enrolled and divided into tumor and non-tumor groups. The clinical characteristics, condition severity, treatment options, and prognosis of the two groups of patients were compared and analyzed.ResultsEighteen patients with anti-GABABR encephalitis were included, ten of whom had tumors. The comparison of clinical characteristics showed that rates of status epilepticus and coma were significantly higher in the group with tumors (P = 0.013 and P = 0.025, respectively); the incidences of pulmonary infection, respiratory failure, hyponatremia, and hypoproteinemia were also substantially more frequent in the tumor group (P = 0.054, P = 0.036, P = 0.015, and P = 0.025, respectively). The laboratory test result comparison showed that serum neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA) were present only in the group with tumors (P = 0.036 and P = 0.092, respectively), but there was no significant difference in the occurrence of elevated CEA between the two groups. Conversely, the percentage of serum systemic autoimmune antibodies was higher in the group without tumors than in the group with tumors (P = 0.043). Patients with tumors tended to have poor outcomes (P = 0.152, OR: 7.000).ConclusionSevere brain damage and complications occur in patients with anti-GABABR encephalitis and comorbid tumors. Early screening for serum NSE and CEA helps in the early diagnosis and treatment of tumors. The prognosis is much worse for anti-GABABR encephalitis with tumors.
Effect of weekend versus weekday admission on the mortality of acute ischemic stroke patients in China: an analysis of data from the Chinese acute ischemic stroke treatment outcome registry
Authors: Huang Diandian , Lu Yuxuan , Sun Yongan , Sun Wei , Huang Yining , Tai Liwen , Li Guozhong , Chen Huisheng , Zhang Guiru , Zhang Lei , Sun Xuwen , Qiu Jinhua , Wei Yan , Jin Haiqiang 
Published: July 2023

BackgroundDue to disparities in medical resources in rural and urban areas as well as in different geographic regions in China, the effect of weekend versus weekday admission on the outcomes of acute ischemic stroke (AIS) patients is unknown. Our aim was to investigate whether the outcomes of AIS patients differ according to the day of admission in China.MethodsThe data were extracted from the Chinese Acute Ischemic Stroke Treatment Outcome Registry (CASTOR), a multicenter prospective study database of patients diagnosed with AIS. The chi-square test (χ2) and logistic regression were used to assess mortality for weekday and weekend admissions among AIS patients stratified by rural or urban status and geographic region (including the eastern, northeastern, central, and western regions).ResultsIn total, 9,256 patients were included in this study. Of these patients, 57.2% were classified as urban, and 42.8% were classified as rural. A total of 6,760 (73%) patients were admitted on weekdays, and 2,496 (27%) were admitted on weekends. There was no significant difference in the mortality rate among patients admitted on weekends compared with those admitted on weekdays in urban (7.5% versus 7.4%) or rural areas (8.8% versus 8.1%; p &gt; 0.05). The mortality rate was the highest among patients admitted on weekends and weekdays (11.6% versus 10.3%) in the northeastern area, without statistical significance before and after adjusting for the patients’ background characteristics (p &gt; 0.05). In addition, regression analysis revealed that the mortality of patients admitted on weekdays was more likely to be influenced by regional subgroup, hospital level and intravenous thrombolysis than that of patients admitted on weekends.ConclusionThe weekend effect was not observed in the mortality of patients with AIS regardless of rural–urban status or geographic region in China.