bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-distance spread of Tembusu virus, and its dispersal in local mosquitoes and domestic poultry in Chongming Island, China
Authors: Fang Yuan , Hang Tian , Yang Li-Min , Xue Jing-Bo , Fujita Ryosuke , Feng Xue-Song , Jiang Tian-Ge , Zhang Yi , Li Shi-Zhu , Zhou Xiao-Nong 
Published: May 2023

Abstract
Background
Chongming Island in China serves as a breeding and shelter point on the East Asian–Australasian Flyway. The resting frequency of migratory birds, abundance of mosquito populations, and the popular domestic poultry industry pose a potential risk of mosquito-borne zoonotic diseases. The aim of this study is to explore the role of migratory birds in the spread of mosquito-borne pathogens and their prevalent status on the island.

Methods
We conducted a mosquito-borne pathogen surveillance in 2021, in Chongming, Shanghai, China. Approximately 67,800 adult mosquitoes belonging to ten species were collected to investigate the presence of flaviviruses, alphaviruses, and orthobunyaviruses by RT-PCR. Genetic and phylogenetic analyses were conducted to explore the virus genotype and potential nature source. Serological survey was performed by ELISA to characterize Tembusu virus (TMUV) infection among domestic poultry.

Results
Two strains of TMUV and Chaoyang virus (CHAOV) and 47 strains of Quang Binh virus (QBV) were detected in 412 mosquito pools, with the infection rate of 0.16, 0.16, and 3.92 per 1000 Culex tritaeniorhynchus, respectively. Furthermore, TMUVs viral RNA was found in serum samples of domestic chickens and faecal samples of migratory birds. Antibodies against TMUV were detected in domestic avian serum samples, generally ranging from 44.07% in pigeons to 55.71% in ducks. Phylogenetic analyses indicated that the TMUV detected in Chongming belonged to Cluster 3, Southeast Asia origin, and most closely related to the CTLN strain, which caused a TMUV outbreak in chickens in Guangdong Province in 2020, but distant from strains obtained previously in Shanghai, which were involved in the 2010 TMUV outbreak in China.

Conclusions
We speculate that the TMUV was imported to Chongming Island through long-distance spreading by migratory birds from Southeast Asia, followed by spill over and transmission in mosquitoes and domestic avian species, threatening the local domestic poultry. In addition, the expansion and prevalence of insect-specific flaviviruses and its simultaneous circulation with mosquito-borne virus are worthy of close attention and further study.
The prevalence of soil transmitted helminths and its influential factors in Shandong Province, China: an analysis of surveillance data from 2016 to 2020
Authors: Xu Yan , Wang Yongbin , Wang Longjiang , Kong Xiangli , Yan Ge , Li Yuejin , Bu Cancan , Zhang Benguang 
Published: May 2023

Abstract
Background
Soil-transmitted helminths (STHs) were previously endemic in Shandong Province, China. This study aimed to analyze the STHs prevalence trend and the natural, social, and human cognitive and behavioural factors influencing the discrepancies between high and low infection levels from 2016 to 2020 in Shandong Province in eastern China.

Methods
STHs surveillance data of Shandong Province from 2016 to 2020 were obtained from China Information Management System for Prevention and Control of Parasitic Diseases. STHs infections were detected by modified Kato–Katz method. Comprehensive information on the natural and social factors, STHs-related knowledge and behaviours were collected through questionnaire surveys. Retrospective spatial scan analysis was performed using SaTScan v10.1 to evaluate any identified spatial clusters of STHs infection for statistical significance and Bayes discriminant analysis was used to discriminate the high or low infection groups of the villages.

Results
In total, 72,160 participants were involved in our survey from 2016 to 2020. The overall STHs prevalence rate was 1.13%, with the eastern region of Shandong Province having the highest rate (2.02%). The predominant species was T. trichiura, with the prevalence rate of 0.99% and the ≥ 70-year age group possessed the highest rate of 2.21%. The STHs prevalence rate showed an annual linear downward trend from 2016 to 2020 ($$\chi_{{{\text{trend}}}}^{2}$$

χ

trend

2

= 127.600, P < 0.001). Respondents aged ≥ 60 years had the lowest awareness level of STHs-related prevention knowledge (all P < 0.05), and were the most likely to adopt the practice of fertilizing with fresh stool (χ2 = 28.354, P < 0.001). Furthermore, the southern region demonstrated the highest temperature and rainfall level and the lowest GNP and annual net income per capita (all P < 0.05).

Conclusions
There is a remarkable declining in STHs prevalence in Shandong Province from 2016 to 2020. However, the prevalence rates of STHs especially T. trichiura in the southern and eastern regions were still high, and the elderly were more susceptible to be infected with STHs owning to their low awareness level of STHS-related prevention knowledge and high adoption rate of dangerous production and living behaviours. Integrated approaches of health education, environment improvement and behaviour change should be strengthened to obtain a further reduction of STHs prevalence in China.
Outcomes for binge eating disorder in a remote weight-inclusive treatment program: a case report
Authors: Shepherd Caitlin B. , Boswell Rebecca G. , Genet Jessica , Oliver-Pyatt Wendy , Stockert Christine , Brumm Rebecca , Riebl Shaun , Crowe Elsbeth 
Published: May 2023

Abstract
Background
There are no known published reports on outcomes for medically and psychiatrically compromised patients with binge eating disorder (BED) treated remotely in higher level of care settings. This case report presents outcomes of an intentionally remote weight-inclusive partial hospitalization and intensive outpatient program based on Health at Every Size® and intuitive eating principles.

Case presentation
The patient presented with an extensive trauma background and long history of disturbed eating and body image. She was diagnosed with BED along with several comorbidities, most notably major depressive disorder with suicidality and non-insulin dependent diabetes mellitus. She completed a total of 186 days in the comprehensive, multidisciplinary treatment program encompassing individual and group therapy, as well as other supportive services such as meal support and in vivo exposure sessions. Upon discharge, her BED was in remission, her major depressive disorder was in partial remission, and she no longer exhibited signs of suicidality. Overall, she showed decreases in eating disorder, depressive, and anxiety symptoms as well as increases in quality of life and intuitive eating throughout treatment, which were largely maintained after one year.

Conclusions
This case highlights the potential of remote treatment as an option for individuals with BED, especially in cases where access to higher levels of care might be limited. These findings exemplify how a weight-inclusive approach can be effectively applied when working with this population.
Advancements in visible-light-driven double perovskite nanoparticles for photodegradation
Authors: Jana Runia , Rajaitha P. Mary , Hajra Sugato , Kim Hoe Joon 
Published: May 2023

AbstractPerovskites are of significant interest in the field of photocatalysis. To date, many perovskite nanostructures have been developed, and their applications in photocatalysis have been studied. There has been considerable improvement in the research on metal doping in the perovskite structure to improve their optical and structural properties. This mini-review examines the recent progress in the synthesis of lead-free double perovskite nanoparticles and their application in visible-light photocatalysis. Lead-free perovskites are emerging as an eco-friendly solution in energy, electrochemistry, and sensing. Double perovskites are known for their flexible structural, optical, and morphological properties due to their lattice framework having a general form AAʹBBʹO6. They are more useful for hydrogen evolution due to their higher conduction band potential than simple perovskites. Here, we summarize the current progress and provide insights for the future development of double perovskites toward efficient photodegradation.
CICHMKG: a large-scale and comprehensive Chinese intangible cultural heritage multimodal knowledge graph
Authors: Fan Tao , Wang Hao , Hodel Tobias 
Published: May 2023

Abstract
Intangible Cultural Heritage (ICH) witnesses human creativity and wisdom in long histories, composed of a variety of immaterial manifestations. The rapid development of digital technologies accelerates the record of ICH, generating a sheer number of heterogenous data but in a state of fragmentation. To resolve that, existing studies mainly adopt approaches of knowledge graphs (KGs) which can provide rich knowledge representation. However, most KGs are text-based and text-derived, and incapable to give related images and empower downstream multimodal tasks, which is also unbeneficial for the public to establish the visual perception and comprehend ICH completely especially when they do not have the related ICH knowledge. Hence, aimed at that, we propose to, taking the Chinese nation-level ICH list as an example, construct a large-scale and comprehensive Multimodal Knowledge Graph (CICHMKG) combining text and image entities from multiple data sources and give a practical construction framework. Additionally, in this paper, to select representative images for ICH entities, we propose a method composed of the denoising algorithm (CNIFA) and a series of criteria, utilizing global and local visual features of images and textual features of captions. Extensive empirical experiments demonstrate its effectiveness. Lastly, we construct the CICHMKG, consisting of 1,774,005 triples, and visualize it to facilitate the interactions and help the public dive into ICH deeply.
Big Data in multiscale modelling: from medical image processing to personalized models
Authors: Geroski Tijana , Jakovljević Djordje , Filipović Nenad 
Published: May 2023

AbstractThe healthcare industry is different from other industries–patient data are sensitive, their storage needs to be handled with care and in compliance with regulative, while prediction accuracy needs to be high. This fast expansion in medical image modalities and data collection leads to generation of so called “Big Data” which is time-consuming to be analyzed by medical experts. This paper provides an insight into the Big Data from the aspect of its role in multiscale modelling. Special attention is paid to the workflow, starting from medical image processing all the way to creation of personalized models and their analysis. A review of literature regarding Big Data in healthcare is provided and two proposed solutions are described–carotid artery ultrasound image processing and 3D reconstruction, and drug testing on personalized heart models. Related to the carotid artery ultrasound image processing, the starting point is ultrasound images, which are segmented using convolutional neural network U-net, while segmented masks were further used in 3D reconstruction of geometry. Related to the drug testing on personalized heart model, similar approach was proposed, images were used in creation of personalized 3D geometrical model that is used in computational modelling to determine pressure in the left ventricle before and after drug testing. All the aforementioned methodologies are complex, include Big Data analysis and should be performed using servers or high-performance computing. Future development of Big Data applications in healthcare domains offers a lot of potential due to new data standards, rapid development of research and technology, as well as strong government incentives.
The 2022 Mw6.2 Pasaman, Indonesia, earthquake sequence and its implication of seismic hazard in central-west Sumatra
Authors: Wulandari Rizki , Chan Chung-Han , Wibowo Adhi 
Published: May 2023

AbstractThe 2022 Mw6.2 Pasaman earthquake took place in central-west Sumatra in association with activity in the Sumatran Fault system. This study clarifies the spatial and temporal distribution of the Pasaman earthquake sequence and forecasts the earthquake sequence’s impact on the seismicity in the vicinity and in the Sumatran Fault system. We first examined the seismicity before the mainshock and observed temporal lowb-value anomalies, shedding light on the earthquake’s precursor by monitoringb-values prior to the event. Based on the aftershocks in the first 18 days, we modeled the temporal distribution of the aftershocks according to the modified Omori’s law, which suggested this sequence could last 49–473 days. By further considering Båth’s law and the Gutenberg–Richter law, we estimated the temporal distribution of the maximum magnitudes in the aftershock sequence. To understand the spatial pattern of the aftershocks, we calculated the coseismic Coulomb stress change imparted by the Pasaman mainshock. Considering uncertainties of the Coulomb stress calculations from rupture geometry, mainshock parameters, friction coefficients, and strike angles of the receiver plane, the patterns of the Coulomb stress changes are similar that the stress increases extended northwest and southeast, consistent with aftershock distribution. We further evaluated rupture probability for each segment of the Sumatran Fault. Considering the stress perturbation imparted by the Pasaman earthquake, we expected a seismicity rate increase of ca. 40% at the Sumpur and Sianok segments in the short term. To quantify long-term rupture probability, the recurrence interval and the time elapsed since the previous earthquake were incorporated based on the time-dependent Brownian passage-time model. The earthquake probability at the Sumani segment in the coming 50 years was determined to be 72%. The results of this study have significant implications for subsequent probabilistic seismic hazard assessments, not only for Sumatra but also for certain metropolitan areas in Malaysia and Singapore.
Late recurrent gastric carcinoma 12 years after surgery with attenuation of CD44 variant 9 expression
Authors: Hayashi Hirokatsu , Yasufuku Itaru , Higashi Toshiya , Chikaishi Wakana , Yokoi Ryoma , Fukada Masahiro , Sato Yuta , Asai Ryuichi , Tajima Jesse Yu , Saigo Chiemi , Makiyama Akitaka , Tanaka Yoshihiro , Okumura Naoki , Murase Katsutoshi , Takahashi Takao , Futamura Manabu , Takeuchi Tamotsu , Matsuhashi Nobuhisa 
Published: May 2023

Abstract
Background
Late recurrence of gastric cancer at 10 years post-gastrectomy is extremely rare, and the underlying mechanism remains unclear. We report a para-aortic lymph node metastasis case that recurred 12 years postoperatively.

Case presentation
A 44-year-old woman pathologically diagnosed with moderately to poorly differentiated adenocarcinoma with pT2(SS)pN2cM0pStageIIIA according to the Japanese Classification of Gastric Carcinoma (the 13th Edition) underwent laparoscopic distal gastrectomy with D1 + lymph node dissection. She received adjuvant chemotherapy with tegafur-uracil (400 mg/day) for 2 years. At postoperative year (POY) 5, a swollen lymph node was detected in the No.16b1lat lymph node station. However, positron emission tomography (PET) revealed normal uptake, and the levels of tumor markers were within normal limits; hence, the possibility of metastasis was considered low, and the patient was placed under observation. At POY 12, computed tomography revealed an enlargement of the No.16b1lat lymph node station, and PET showed abnormal uptake. Endoscopic ultrasound-guided fine-needle aspiration revealed a moderately differentiated adenocarcinoma. Hence, a diagnosis of recurrence of gastric cancer was made. The patient underwent para-aortic nodal dissection (PAND) of No.16b1lat & int stations. Immunochemical staining results also suggested the recurrence of gastric cancer. However, the expression of CD44 variant 9 (CD44v9), a cancer stem cell marker for gastric adenocarcinoma, was attenuated in the recurrent lesions compared with that in the primary lesions. Postoperatively, she received chemotherapy with tegafur–gimeracil–oteracil (80 mg/day) for 1 year. Bone metastasis was observed at POY 4 after PAND, and the IHC analysis showed a HER2 score of 3 + in a needle biopsy specimen of bone metastasis. The expression of CD44v9 was slightly positive. The patient is being treated with chemotherapy with FOLFOX + trastuzumab.

Conclusions
A defense mechanism against reactive oxygen species has been reported as a mechanism causing recurrence of CD44v9-positive gastric cancer. Consequently, CD44v9-positive gastric cancer grows in metastatic organs, repeatedly self-renews, and proliferates to form recurrent lesions. In the present case, the degree of CD44v9 staining in recurrent lesions was suggested to be related to the recurrence time.
Implementation of a novel program to support colorectal cancer screening in a community health center consortium before and after the onset of COVID-19: a qualitative study of stakeholders’ perspectives
Authors: Santiago-Rodríguez Eduardo J. , Hoeft Kristin S. , Lugtu Kara , McGowen Matthew , Ofman David , Adler Jaime , Somsouk Ma , Potter Michael B. 
Published: May 2023

Abstract
Background
In 2017, the San Francisco Cancer Initiative (SF CAN) established the Colorectal Cancer (CRC) Screening Program to provide technical assistance and financial support to improve CRC screening processes, and outcomes in a consortium of community health centers (CHCs) serving low-income communities in San Francisco. The purpose of this study was twofold: to evaluate the perceived influence of the support provided by the CRC Screening Program’s Task Force on CRC screening processes and outcomes in these settings and to identify facilitators and barriers to SF CAN-supported CRC screening activities before and after the onset of the COVID-19 pandemic.

Methods
Semi-structured key informant interviews were conducted with consortium leaders, medical directors, quality improvement team members, and clinic screening champions. Interviews were audio-recorded, professionally transcribed, and analyzed for themes. The Consolidated Framework for Implementation Research (CFIR) was used to develop the interview questions and organize the analysis.

Results
Twenty-two participants were interviewed. The most commonly cited facilitators of improved screening processes included the expertise, funding, screening resources, regular follow-up, and sustained engagement with clinic leaders provided by the task force. The most salient barriers identified were patient characteristics, such as housing instability; staffing challenges, such as being understaffed and experiencing high staff turnover; and clinic-level challenges, such as lack of ability to implement and sustain formalized patient navigation strategies, and changes in clinic priorities due to the COVID-19 pandemic and other competing health care priorities.

Conclusions
Implementing CRC screening programs in a consortium of CHCs is inherently challenging. Technical assistance from the Task Force was viewed positively and helped to mitigate challenges both before and during the pandemic. Future research should explore opportunities to increase the robustness of technical assistance offered by groups such as SF CAN to support cancer screening activities in CHCs serving low-income communities.
Bilateral antrochoanal polyps in a Sudanese patient: a case report
Authors: Kardman Siddig E. , Khalid Osama M. , Yagi Hashim I. 
Published: May 2023

Abstract
Background
Antrochoanal polyps (ACPs) are pathologically benign nasal swellings. The maxillary sinus is the commonest reported origin. The polyps are usually unilateral and often exit through the progressively widened maxillary sinus ostium to occupy the choana and may reach the nasopharynx. It is a disease of adolescents and young adults who often present with progressive unilateral nasal obstruction. Encountering bilateral antrochoanal polyps is very rare.

Case presentation
We report a forty years old male who had progressive bilateral nasal obstruction for 8 years associated with hyposmia and intermittent facial pain and headaches. A nasal mass could be seen on anterior rhinoscopy on both sides, more prominent on the left. Endoscopy revealed bilateral masses hanging down the choanae. Computerized tomography scan of the nose and paranasal sinuses demonstrated bilateral nasal polypi and widening of the maxillary sinus ostia. During endoscopic surgical excision of the lesions, polypi were found to dilate the ostia of both maxillary sinuses. The polypi had antral, nasal, and choanal parts typical of antrochoanal polypi on both sides. The histopathology showed the inflammatory nature characteristic of antrochoanal polyp. Postoperatively, the patient’s symptoms resolved dramatically, and he is on continuous regular scheduled follow-up.

Conclusion
Bilateral antrochoanal polyps can present with nasal obstruction and can be misdiagnosed as sinusitis; radiological and endoscopic features are useful to reach specific diagnosis; what is special about our presentation is that it is an addition to the literature of a rare disease (bilateral ACPs), and we are reporting it in an older age rather than the common younger age of presentation in the literature reports, which is an addition to the demographic data.
Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly
Authors: Wang Yan , Ling Xiaobin , Zhang Chong , Zou Jian , Luo Bingnan , Luo Yongbo , Jia Xinyu , Jia Guowen , Zhang Minghua , Hu Junchao , Liu Ting , Wang Yuanfeiyi , Lu Kefeng , Li Dan , Ma Jinbiao , Liu Cong , Su Zhaoming 
Published: May 2023

AbstractSARS-CoV-2 and its variants, with the Omicron subvariant XBB currently prevailing the global infections, continue to pose threats on public health worldwide. This non-segmented positive-stranded RNA virus encodes the multi-functional nucleocapsid protein (N) that plays key roles in viral infection, replication, genome packaging and budding. N protein consists of two structural domains, NTD and CTD, and three intrinsically disordered regions (IDRs) including the NIDR, the serine/arginine rich motif (SRIDR), and the CIDR. Previous studies revealed functions of N protein in RNA binding, oligomerization, and liquid–liquid phase separation (LLPS), however, characterizations of individual domains and their dissected contributions to N protein functions remain incomplete. In particular, little is known about N protein assembly that may play essential roles in viral replication and genome packing. Here, we present a modular approach to dissect functional roles of individual domains in SARS-CoV-2 N protein that reveals inhibitory or augmented modulations of protein assembly and LLPS in the presence of viral RNAs. Intriguingly, full-length N protein (NFL) assembles into ring-like architecture whereas the truncated SRIDR-CTD-CIDR (N182-419) promotes filamentous assembly. Moreover, LLPS droplets of NFL and N182-419 are significantly enlarged in the presence of viral RNAs, and we observed filamentous structures in the N182-419 droplets using correlative light and electron microscopy (CLEM), suggesting that the formation of LLPS droplets may promote higher-order assembly of N protein for transcription, replication and packaging. Together this study expands our understanding of the multiple functions of N protein in SARS-CoV-2.
Compulsory community treatment orders (CTOs): recent research and future directions
Authors: Beaglehole Ben , Tennant Matthew 
Published: May 2023

Summary
Compulsory community treatment orders (CTOs) are controversial because the right to refuse treatment is overridden, even when patients may not be acutely unwell. Scrutiny of outcomes associated with CTOs is therefore required. This editorial provides an overview of the evidence for CTOs. It also discusses recent papers reporting outcomes associated with CTOs and makes recommendations for researchers and clinicians to consider.