bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of conductive smart composite polymeric materials for potential applicationsin structural health monitoring and strain detection
Authors: Sanchez-Sobrado Olalla , Rodriguez Daniel , Losada Ricardo , Rodriguez Elena 
Published: March 2023

AbstractThe presented work collects results from the evaluation of electrical response to mechanical deformation and formation of defects presented by different polymeric based composite materials with potential for applications in Structural Health Monitoring and Strain Detection. With the aim of showing the variety of key materials in sectors like civil aviation, wind energy, automotive or railway that present this ability, specimens of very different nature have been analyzed: a) thermoplastic commercial 3D printing filaments loaded with carbonic fillers; b) epoxy resin loaded with Carbon Nanotubes and c) long carbon fiber reinforced resin composite. Measurements of electrical properties of these materials were taken to evaluate their capability to detect the presence of structural defects of different sizes as well as its spatial location. On the other hand, simultaneous measurements of electrical resistivity and mechanical strain during tensile tests were performed to analyze the potential of materials as strain detectors. All composites studied have shown a positive response (modification of electrical performance) to external mechanical stimulus: induced damage and deformations.
Graphical Abstract
Subdural hematoma following dural puncture epidural anesthesia for labor analgesia: two case reports
Authors: Chou Wendy , Alam Saamia , Bracero Lucas , Schabel Joy , Bergese Sergio , Costa Ana 
Published: March 2023

Abstract
Background
Neuraxial anesthesia is widely used for labor analgesia in the USA, such as epidural, combined spinal–epidural, and dural puncture epidural (DPE). Post-dural puncture headache (PDPH) is a well-known complication of neuraxial anesthesia. However, a rare yet more serious complication is subdural hematomas. Untreated subdural hematomas can result in permanent disability and death, hence the need to better understand their development in the obstetric population receiving DPE.

Case presentation
Case one: A 34-year-old G6P3 female at 39-week gestation received a DPE for labor analgesia and underwent a cesarean section for arrest of descent. On postoperative day two, the patient developed a PDPH but opted for conservative treatment. Ten days post-discharge, the patient presented with a large subacute to chronic subdural hematoma with midline shift. The patient underwent a right fronto-temporal craniectomy, evacuation of subdural hematoma, and placement of a subdural drain. Case two: A 31-year-old G1P0 female at 41-week gestation with a past medical history of a chronic right parietal hemangioma and malaria at 29-week gestation received a DPE for induction of labor. She subsequently underwent a primary cesarean section for failure to progress and persistent category-two fetal heart rate tracing. On postoperative day 11, she experienced a severe non-positional right-sided headache. Imaging revealed a subdural hematoma overlying the right frontal temporal and parietal lobes, which was observed and managed non-operatively. On postoperative day 14, the patient received an epidural blood patch for symptomatic intracranial hypotension.

Conclusion
PDPH, a complication of neuraxial anesthesia, is typically benign and often self-resolves with conservative measures. However, to avoid increased morbidity and mortality, monitoring in patients with PDPH at a higher risk for development of subdural hematomas (especially those with known preexisting intracranial pathologies) is critical for prompt diagnosis. As exemplified by our second case, epidural blood patches continue to be effective and may be considered in patients with symptomatic intracranial hypotension.
Design of new reversible and selective inhibitors of monoamine oxidase A and a comparison with drugs already approved
Authors: Reyes-Chaparro A. , Flores-Lopez N. S. , Quintanilla-Guerrero F. , Nicolás-Álvarez Dulce Estefanía , Hernandez-Martinez A. R. 
Published: March 2023

Abstract
Background
Monoamine oxidase (MAO) is an enzyme that has been targeted pharmacologically for the treatment of depression and neurodegenerative diseases such as Parkinson's disease. To avoid side effects, drugs currently in use must selectively target either of the enzyme's two isoforms, A or B. In this study, we designed molecules derived from chalcone as potential reversible and selective inhibitors of isoform A of the MAO enzyme.

Results
Ten thousand one hundred compounds were designed and screened using molecular docking, considering the pharmacokinetic processes of chemical absorption, distribution, metabolism, and excretion. Density functional theory calculations were performed for the main ligands to evaluate their reactivity. Six drugs qualified as reversible and irreversible inhibitors of both isoform A and isoform B. Among these, molecule 356 was found to be a reversible inhibitor with the best performance in selectively targeting isoform A of the MAO enzyme. The interaction stability of ligand 356 in the isoform A binding site was confirmed by molecular dynamics. One hydrogen bond was found between the ligand and the cofactor, and up to six hydrogen bonds were formed between the ligand and the protein.

Conclusions
We selected a drug model (molecule 356) for its high affinity to isoform A over isoform B of the MAO enzyme. This proposal should decrease experimental costs in drug testing for neurodegenerative diseases. Therefore, our silico design of a reversible inhibitor of isoform A of enzyme monoamine oxidase can be used in further experimental designs of novel drugs with minimal side effects.

Graphical Abstract
Rapidly progressive glomerulonephritis secondary to anti-GBM disease associated with MPO-ANCA: a case report
Authors: Isaza-Meza Mariana , Afanador-Rubio Diana Carolina , Huérfano-Castro Manuel Alejandro , Ramírez-Correa Ivon , Flórez-Vargas Adriana Alejandra 
Published: March 2023

Abstract
Background
Anti-glomerular basement membrane (GBM) disease and ANCA-associated vasculitis (AAV) diseases are rare. It is associated with variable renal manifestations and increased mortality, thus requiring early aggressive treatment to minimize adverse outcomes and improve prognosis.

Case presentation
We present the case of a male patient with 1-month onset of asthenia, adynamia, oliguria, and weight loss. Initial laboratory findings were indicative of severe kidney dysfunction. The urinalysis showed active sediment, but the urinary tract ultrasound was unaltered. As these findings were consistent with rapidly progressive glomerulonephritis, he received steroid pulses, and given the severity of the condition, renal replacement therapy was initiated. Other diagnostic tests revealed MPO-ANCA antibody levels of 26 mg/dl, pANCAs 1/320, and anti-GBM of 8 mg/dl. Kidney biopsy evidenced necrotizing glomerulonephritis with extracapillary proliferation in 90% of the glomeruli. The patient received plasma exchange (PE) therapy and intravenous (IV) cyclophosphamide (CYC) cycles; however, he presented with severe alveolar hemorrhage requiring the completion of 21 PE sessions and 3 CYC boluses. Pulmonary symptoms resolved, but the patient persisted dependent on dialysis. During the outpatient follow-up, monthly CYC were prescribed until circulating antibody levels were normal; however, the patient did not recover full kidney function and remained dependent on renal support.

Conclusions
Anti-GBM and AAV diseases are rare; therefore, anti-GBM antibodies should be screened simultaneously in patients with ANCA positive, especially in older patients, due to the early morbidity and mortality typical of anti-GBM disease with comparable disease severity it represents.
Testing relationship between tea intake and the risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study
Authors: Lu Rong-Bin , Huang Jian 
Published: March 2023

Abstract
Background
We performed Mendelian randomization (MR) to assess the causal effect of tea intake on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Methods
Genetic instruments for tea intake were obtained from a large genome-wide association study (GWAS) dataset of the UK Biobank. Genetic association estimates for RA (6236 cases and 147,221 controls) and SLE (538 cases and 213,145 controls) were obtained from the FinnGen study through the IEU GWAS database.

Results
MR analyses using the inverse-variance weighted method showed that tea intake was not associated with risk of RA [odds ratio (OR) per standard deviation increment in genetically predicted tea intake = 0.997, 95% confidence interval (CI) 0.658–1.511] and SLE (OR per standard deviation increment in genetically predicted tea intake = 0.961, 95% CI 0.299–3.092). Weighted median, weighted mode, MR-Egger, leave-one-out and multivariable MR controlling for several confounding factors including current tobacco smoking, coffee intake, and alcoholic drinks per week yielded completely consistent results. No evidence of heterogeneity and pleiotropy was found.

Conclusion
Our MR study did not suggest a causal effect of genetically predicted tea intake on RA and SLE.
Brazilian society of rheumatology methodological guide for the development of evidence-based clinical guidelines in rheumatology
Authors: de Melo Ana Karla Guedes , Caparroz Ana Luíza Mendes Amorim , de Abreu Mirhelen Mendes , Azevedo Daniela Castelo , Hoff Leonardo Santos , Kowalski Sérgio Candido , Torres Themis Mizerkowski , Barros Solange Murta , Ferreira Gilda Aparecida , Montecielo Odirlei André , Xavier Ricardo Machado , Trevisani Virgínia Fernandes Moça 
Published: March 2023

AbstractClinical practice guidelines (CPG) are developed to align standards of health care around the world, aiming to reduce the incidence of misconducts and enabling more effective use of health resources. Considering the complexity, cost, and time involved in formulating CPG, strategies should be used to facilitate and guide authors through each step of this process. The main objective of this document is to present a methodological guide prepared by the Epidemiology Committee of the Brazilian Society of Rheumatology for the elaboration of CPG in rheumatology. Through an extensive review of the literature, this study compiles the main practical recommendations regarding the following steps of CPG drafting: distribution of working groups, development of the research question, search, identification and selection of relevant studies, evidence synthesis and quality assessment of the body of evidence, the Delphi methodology for consensus achievement, presentation and dissemination of the recommendations, CPG quality assessment and updating. This methodological guide serves as an important tool for rheumatologists to develop reliable and high-quality CPG, standardizing clinical practices worldwide.
The regulatory subunit MoB56 of PP2A phosphatase regulates pathogenicity, growth and development in a protein complex with the atypical catalytic subunit Ppg1 in the rice blast fungus Magnaporthe oryzae
Authors: Wang Rui-Jin , Cui Danrui , Zhao Rui , Jin Yujie , Zeng Wenhui , Yang Ye , Qi Linlu , Xiang Lihui , Peng You-Liang 
Published: March 2023

AbstractProtein phosphatase 2A (PP2A) is usually a heterotrimeric enzyme, consisting of a catalytic subunit (C) and a scaffolding subunit (A) associated with a third, variable regulatory subunit (B). Fungi usually carry a single gene for A and C subunits, and three genes for the B subunit. In addition, fungi contain a conserved atypical C subunit named Ppg1, which is essential to the pathogenicity of the rice blast fungus Magnaporthe oryzae. However, it remains largely unknown how the B subunit combinatorically assembles with the A and C subunits or Ppg1 to regulate fungal growth, development and pathogenicity. Here we report and functionally characterize one regulatory subunit of PP2A, named MoB56, in M. oryzae. We generated a MoB56 deletion mutant Δmob56, which was severely defective in vegetative growth, conidiation and septum formation, and had lost pathogenicity. The defects of Δmob56 could be rescued by introducing MoB56 fused with GFP (MoB56-GFP) at its C terminus. Fluorescence microscopic observations revealed that the MoB56-GFP signals were widely distributed in the cytoplasm and formed a dot-like structure at the center of the septum in conidia, appressoria and infection hyphae, supporting its function in septation. Further, we performed co-immunoprecipitation and pull-down assays, indicating that MoB56 forms a protein complex with the A subunit and Ppg1 in mycelial cells. The yeast two-hybrid assay showed that MoB56 could interact with the A subunit of PP2A but not with Ppg1, while Ppg1 could interact with the A subunit, suggesting that the A subunit ties MoB56 with Ppg1 for the protein complex formation. In addition, we revealed that MoB56 has multiple isoforms, which are likely originated from alternative splicing and sumoylation. This is the first report revealing that the regulatory subunit B56 is associated with the PP2A-like phosphatase Ppg1 in fungi. Importantly, this study showed that B56, like Ppg1, is essential to the pathogenicity of M. oryzae, offering a potential new lead to control this devastating fungal pathogen by targeting specific PP2A-like phosphatase. Together, this study provides important information for understanding how the regulatory subunit B56 of PP2A regulates fungal pathogenicity and for the control of rice blast disease.
Delayed seropositivity is associated with lower levels of SARS-CoV-2 antibody levels in patients with mild to moderate COVID-19
Authors: Fekry Marwa M. , Soliman Hanan , Hashish Mona H. , Selim Heba S. , Osman Nermin A. , Omran Eman A. 
Published: March 2023

Abstract
Background
Patients with COVID-19 can develop a range of immune responses, including variations in the onset and magnitude of antibody formation. The aim of this study was to investigate whether SARS-CoV-2 antibody levels vary in patients with mild to moderate COVID-19 in relation to the onset (days) of their post-symptom seropositivity and to explore host factors that may affect antibody production

Methods
This was a prospective, multiple measurements study involving 92 PCR-confirmed patients with mild to moderate COVID-19. Antibody testing for anti-nucleocapsid (anti-NP) and spike proteins (anti-S) was performed using ELISA tests. Serum samples were collected over a period of 55 days from symptom onset of COVID-19 infection, and repeated as necessary until they turned positive.

Results
No significant differences were found between the positivity rates of anti-S or anti-NP regarding any clinical symptom (p > 0.05). The majority of patients who tested positive for anti-NP and anti-S showed early seropositivity (within 15 days of symptom onset) (75.9% for anti-NP and 82.6% for anti-S). Younger patients, those without chronic diseases, and non-healthcare workers had the highest percentage of seroconversion after day 35 post-symptom onset (p = 0.002, 0.028, and 0.036, respectively), while older patients and those with chronic diseases had earlier seropositivity and higher anti-NP levels (p = 0.003 and 0.06, respectively). Significantly higher anti-S ratios were found among older (p = 0.004), male (p = 0.015), and anemic patients (p = 0.02). A significant correlation was found between both antibodies (p = 0.001). At the end of the study, the cumulative seroconversion rate for both antibodies was almost 99%.

Conclusions
Some COVID-19 patients may exhibit delayed and weak immune responses, while elderly, anemic patients and those with chronic diseases may show earlier and higher antibody responses.
A life cycle assessment of drilling waste management: a case study of oil and gas condensate field in the north of western Siberia, Russia
Authors: Ilinykh Galina , Fellner Johann , Sliusar Natalia , Korotaev Vladimir 
Published: March 2023

AbstractOil production is currently impossible without drilling wells, so millions of tons of drilling waste contaminated with oil, chlorides, and heavy metals are generated every year in Russia alone. This article presents the results of a comparative life cycle assessment of water-based drill cuttings management technologies applied in Russia, including disposal, solidification, and reinjection. Life cycle assessment of the drilling waste management was performed using OpenLCA software, Ecoinvent 3.8 database and ReCiPe Midpoint (H) impact assessment method. Fossil depletion, climate change and human toxicity were chosen as impact categories. Data from oil producing companies on the composition of drilling waste and information from drilling waste treatment companies on the technologies and reagents used were also applied. To compare alternative technologies the following scenarios were compared: Scenario 0 «Landspraying», scenario 1 «Disposal», scenario 2 «Solidification» (scenario 2a – in a waste pit, scenario 2b – without a waste pit), and scenario 3 «Reinjection». Sensitivity analysis was performed to test for variations in results for oilfields located in different regions and for differences in mass of reagents used. The environmental impact of scenario 0 (landspraying) depends mostly on drilling waste composition, which is largely determined by human toxicity that can differ from 17 up to 2642 kg 1,4-DCB-eq per 1 t of drill cuttings, when for other scenarios it is from 24 up to 73 kg 1,4-DCB-eq per 1 t of drill cuttings. It means, that drilling waste landspraying is the best option only if the level of pollutants in the waste is very low. Among the other scenarios of drill cuttings management aimed at isolating pollutants from the environment, solidification technologies have the greatest environmental impact, primarily due to their use of binders. Among all scenarios, 2a and 2b have the biggest environmental effect in most impact categories. The production of cement and lime for drilling waste solidification was the main contributor to fossil depletion (64% of the total amount for scenario 2a and 54% for scenario 2b), and greenhouse gas emissions (49% of the total amount for scenario 2a and 70% for scenario 2b). However, the application of soil-like material (solidified drill cuttings) as an inert ground in swampy areas can make migration of heavy metals possible. Scenario 3 (reinjection) is associated with the least impact on the environment and the main contributor is electricity production (75% of greenhouse gas emissions). Sensitivity analysis shows that oilfield location does not affect the data for reinjection, but the impact assessment changes up to 60% for drill cutting disposal due to different waste pit design depending on permafrost and groundwater levels. Differences in the mass of used cement and lime change results for solidification scenarios considerably (up to 80%).
Cardiovascular disease protective properties of blueberry polyphenols (Vaccinium corymbosum): a concise review
Authors: Onuh John O. , Dawkins Norma L. , Aluko Rotimi E. 
Published: March 2023

AbstractIncreasing epidemiological evidence suggests inverse association between consumption of diets rich in fruits and vegetables and the incidence of cardiovascular diseases (CVD), metabolic syndrome disorders, certain types of cancer, neurodegenerative disorders, and other forms of human chronic diseases. This may be due to the contents of some bioactive phytochemicals, especially polyphenols, which are abundant in fruits and vegetables and have antioxidant effects. Berry fruits are reported to have the highest total antioxidant capacity (TAC) among fruits. They may protect against CVD and hypertension either directly or in tandem with other cellular mechanisms. Blueberry anthocyanins have been reported to exhibit cardiovascular protective health effects by preventing cholesterol-induced atherosclerosis, and reduction of oxidative and inflammatory damages to the endothelium through several mechanisms. Such mechanisms may involve suppressing the release of inflammatory mediators, protection against ischemic damage of the heart as well as cardiomyocyte survival, lower systolic and mean arterial pressures and renal nitrite content in addition to multiple other beneficial effects. However, several limitations in existing studies make it difficult to draw conclusions regarding the preventive effects of blueberries and other polyphenols-rich foods, especially as data supporting a causal relationship between direct antioxidant capacity and CVD are insufficient or limited. It is also unclear, which molecules exert this effect since few studies with isolated polyphenols have been conducted in addition to a lack of proper understanding of other mechanisms that may be involved. This review is, therefore aimed at discussing some of the current literature information on the cardiovascular protective effects of blueberries with suggestions for future research directions.
Graphical Abstract
Graphical abstract demonstrating the overall mechanisms of CVD protection by blueberry and blueberry polyphenols and anthocyanins. Blueberry consumption leads to reduced CVD complications due to the modulation of several mechanisms associated with CVD.
Meniscus extrusion is a predisposing factor for determining arthroscopic treatments in partial medial meniscus posterior root tears
Authors: Furumatsu Takayuki , Kintaka Keisuke , Higashihara Naohiro , Tamura Masanori , Kawada Koki , Xue Haowei , Ozaki Toshifumi 
Published: March 2023

Abstract
Background
Patients with partial medial meniscus posterior root tears (MMPRTs) sometimes require arthroscopic pullout repair because of their intolerable/repeated knee pains and continuous disturbance in gait during activities of daily living. However, the predisposing factors for future knee surgery in patients with partial MMPRTs remain unclear. We compared the findings of magnetic resonance imaging (MRI) between patients who underwent pullout repair and nonoperative management following partial MMPRTs.

Methods
Twenty-five patients who required arthroscopic repair for partial MMPRTs and 23 patients who were managed nonoperatively were evaluated during a mean follow-up period of 27.1 months. Sex, age, height, body weight, body mass index, duration from onset to initial MRI, MRI findings, and medial meniscus (MM) extrusion were compared between the two groups. Linear regression analysis was used to assess the correlation between MM extrusion and duration from onset to MRI examination.

Results
No significant differences were observed between the pullout repair and nonoperative management groups in terms of patient demographics and the positive ratio of MRI-based root tear signs. However, absolute MM extrusion in the pullout repair group (3.49 ± 0.82 mm) was larger than that in the nonoperative management group (2.48 ± 0.60 mm, P < 0.001). Extrusion of the MM (> 3 mm) was detected more frequently in the pullout repair group than in the nonoperative management group (P < 0.001). The odds ratio in the pullout repair and MM extrusion > 3 mm cases was 9.662. Linear regression analysis revealed a fair correlation between the duration from onset to MRI and MM extrusion only in the pullout repair group (0.462 mm/month increase in MM extrusion).

Conclusions
This study demonstrated that more severe MM extrusions were observed in the pullout repair group than in the nonoperative management group. Major extrusion (> 3 mm) was also observed more in the pullout repair group than in the nonoperative group. Assessing MM extrusion and its severity can help determine a valid treatment for patients with partial MMPRTs.

Level of evidence
IV, Retrospective comparative study.