bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutrophil‐to‐lymphocyte ratio in relation to trauma severity as prognosis factors in patients with multiple injuries complicated by multiple organ dysfunction syndrome: A retrospective analysis
Authors: He Yong‐Ming , Liu Xing , Zhong Si‐Yi , Fu Qiu‐Hong 
Published: September 2023

AbstractObjectiveThis study aimed to explore potential risk factors for the occurrence of multiple organ dysfunction syndrome (MODS) in patients with multiple injuries by evaluating neutrophil‐to‐lymphocyte ratio (NLR)‐associated trauma severity.MethodsThis retrospective case–control study included 95 patients with multiple injuries, who were admitted to our hospital (between January 2018 and December 2020). Clinical data including gender, age, underlying disease, number of injury sites (NIS), injury severity score (ISS), hemoglobin level within 24 h of admission (HL‐24h), neutrophil count (NC), white blood cell count, platelet count (PC), NLR, d‐dimer level, activated partial thromboplastin time (APTT), complicated shock within 24 h of admission (CS‐24h), length of stay, as well as prognostic outcome was systematically analyzed. According to MODS occurrence, patients were divided into a MODS group (n = 27) and a non‐MODS group (n = 68). The risk factors affecting patients with multiple injuries complicated by MODS were identified using univariate and multivariate logistic regression analyses. Candidate risk factors were further analyzed using receiver operating characteristic (ROC) curves.ResultsUnivariate analysis revealed a significant difference between the MODS and non‐MODA groups in terms of NIS, ISS, HL‐24h, PC, APTT, d‐dimer level, CS‐24h, NLR, NC, prognostic outcome, and other indicators (p < .05). Multivariate logistic regression analysis showed that
d‐dimer levels within 24 h of admission and ISS, NLR, and CS‐24h were significantly associated with multiple injuries complicated by MODS. Compared with the non‐MODS controls, the NLR in the MODS group showed a much higher level and tended to rise with the increase in ISS score, indicating a significant intergroup difference (p < .05). The ROC curve analysis results suggested that the NLR had good sensitivity and specificity for predicting the prognosis of patients with MODS with multiple injuries.Conclusiond‐dimer level, ISS, NLR, and CS‐24h are important risk factors for MODS in patients with multiple injuries. Notably, NLR expression may be a good indicator of injury severity and predictor of the occurrence of MODS in patients with multiple injuries. Therefore, assessment of injury severity and coagulation function, active resuscitation, as well as prevention of infection should be emphasized during treatment of multiple injuries, to reduce and prevent the risk of MODS in patients with multiple injuries.
Data are in the eye of the beholder: Co‐creation for sustainable personal data value
Authors: Stelmaszak Marta , Parry Glenn 
Published: September 2023

AbstractRecent scholarship re‐casts the value of data from financial to value in use, where value is a multi‐faceted, dynamic, emergent construct, co‐created by stakeholders. To date, the dynamics of the co‐creation of value from the use of personal data have been investigated from the starting point of use. However, personal data do not have inherent value, rather their value emerges during design against projected future use. We conducted a case study of the development of a personalized e‐book and captured the different perceptions of the value of personal data from firm, intermediary, and customer perspectives, namely means to an end, medium of exchange, and net benefit, respectively. The diversity of perspectives highlights ontological differences in the perception of what data are, which in turn creates epistemological tensions and different expectations of the characteristics of data embedded in value co‐creation. By detailing how the value of personal data is co‐created in practice, we argue that co‐creation during design creates conditions for sustainable data value necessary for the continuing operation of products and services based on personalization.
Short video marketing in tourism: Telepresence, celebrity attachment, and travel intention
Authors: Zhu Chris , Fong Lawrence Hoc Nang , Li Xi , Buhalis Dimitrios , Chen Hong 
Published: September 2023

AbstractDrawn upon Telepresence theory, this study aims to identify the relationships between existential authenticity, celebrity attachment, telepresence, and travel intention in the short video experience. Survey results show that existential authenticity fosters user attachment to celebrity and then travel intention, but has no impact on telepresence which is also not related to travel intention; Furthermore, celebrity attachment enhances travel intention. Although existential authenticity has no effect on telepresence, celebrity attachment mediates the relationship between existential authenticity and telepresence. This study offers insights to both scholars and practitioners, informing strategies for enhancing destination competitiveness through TikTok marketing campaigns.
Health literacy and information needs among German skin cancer patients in comparison to people without skin cancer: A survey
Authors: Hoffmann Julia , Steeb Theresa , Weber Christiane , Doppler Astrid , Schmitt Jochen , Schadendorf Dirk , Berking Carola , Meier Friedegund 
Published: September 2023

AbstractBackgroundAn increasing number of patients are seeking health information on the internet. Health literacy and the quality of information are crucial to enable patients to find relevant high‐quality information.ObjectivesTo investigate the relevance of quality criteria for health information and to determine the health literacy of skin cancer patients (SC) in comparison to those without skin cancer (NSC).MethodsBetween December 2021 until February 2022 we undertook an online survey on the importance of multiple criteria to investigate the relevance of quality criteria of online health information. SC and NSC were eligible for participation. The questionnaire assessed participants´ health information‐seeking behavior and the evaluation of relevance of quality criteria for health information on a 5‐point‐LIKERT‐Scale. The participants´ health literacy was measured according to the health literacy measurement scale ranging from 0‐100. Comparisons between SC and NSC were investigated with t‐tests.ResultsWe retrieved data from 268 participants, of whom 98 (38%) were SC. Participants assigned the highest relevance to the health information topics treatment (4.7 ± 0.64) and effects of a disease (4.49 ± 0.76). Participants ranked the content of information with a mean of 4.72 (±0.57) to be the most relevant criterion, followed by objectivity (4.61 ± 0.67) and completeness of the information (4.59 ± 0.61). Participants showed the highest competence in understanding of information (62.4 ± 22.5) and in disease prevention (58.32 ± 22.9). They reached low values in accessing health related information (46.78 ± 25.62) and appraising it (33.16 ± 20.11). Subgroup analysis indicated that SC had a greater need for practical information that is helpful in dealing with a disease compared to NSC. They showed significantly lower health literacy than NSC.ConclusionsOur study documents that SC and NSC have a high need for different dimensions of quality of health information. These differences in the importance of criteria should be considered in the development of future targeted health information.
Bacterial Cellulose Applied in Wound Dressing Materials: Production and Functional Modification – A Review
Authors: Hou Shuaiwen , Xia Zhaopeng , Pan Jiajun , Wang Ning , Gao Hanchao , Ren Jingli , Xia Xuekui 
Published: September 2023

AbstractIn recent years, the development of new type wound dressings has gradually attracted more attention. Bacterial cellulose (BC) is a natural polymer material with various unique properties, such as ultrafine 3D nanonetwork structure, high water retention capacity, and biocompatibility. These properties allow BC to be used independently or in combination with different components (such as biopolymers and nanoparticles) to achieve diverse effects. This means that BC has great potential as a wound dressing. However, systematic summaries for the production and commercial application of BC‐based wound dressings are still lacking. Therefore, this review provides a detailed introduction to the production fermentation process of BC, including various production strains and their biosynthetic mechanisms. Subsequently, with regard to the functional deficiencies of bacterial cellulose as a wound dressing, recent research progress in this area is enumerated. Finally, prospects are discussed for the low‐cost production and high‐value‐added product development of BC‐based wound dressings.
Metabolic insights into tumor pathogenesis: Unveiling pan‐cancer metabolism and the potential of untargeted metabolomics
Authors: Wang Taorui , Gao Yuanxu 
Published: September 2023

AbstractMetabolic dysregulation is a hallmark of cancer, underpinning diverse aggressive behaviors such as uncontrolled proliferation, immune evasion, and metastasis. Despite the potential of tumor metabolites as biomarkers, their utility has been hampered by metabolic heterogeneity. Exploring cancer metabolism aims to discern shared metabolic pathways and have a better understanding the metabolic heterogeneity of tumors. This approach offers a holistic view of cancer metabolism, facilitating the identification of multicancer‐relevant metabolic targets and the development of more broadly effective therapeutics. In this review, we present a comprehensive overview of the current landscape of cancer metabolism and its prospective applications in cancer diagnosis and prognosis. We delineate common metabolic aberrations observed across a spectrum of cancer types and elucidate the unique metabolic signatures characterizing the six leading causes of cancer‐related mortality. Furthermore, we survey the utilization of untargeted metabolomics and single‐cell technologies in cancer screening, diagnosis, and prognosis, while also spotlighting available data resources for pan‐cancer metabolomics analyses. Throughout this discussion, we tackle prevailing research challenges and propose strategies aimed at enhancing cancer management. Our objective is to furnish valuable insights that can inform and guide future research endeavors in the dynamic realm of cancer metabolism.
p38 mitogen‐activated protein kinase: Functions and targeted therapy in diseases
Authors: Zheng Qinwen , Li Shutong , Wang Aoxue , Zhe Man , Yang Panpan , Wu Yongya , Zhao Min , Zhu Yumeng , Luo Yi , Wang Guan , Ouyang Liang 
Published: September 2023

AbstractP38 mitogen‐activated protein kinase (p38MAPK) is a multifunctional protein kinase that plays an important role in human normal physiological activities and a variety of major diseases, and its signaling pathway affects a variety of regulatory factors in vivo, which is related to cell cycle, survival, metabolism, and differentiation. The four subtypes of p38MAPK have significant differences in their distribution, content, and effects in the body. The inhibitors of the four subtypes play potential roles in regulating cancer, neurodegenerative diseases, inflammation, and cardiovascular diseases, making it an attractive target for drug development. So far, an increasing number of p38MAPK inhibitors have been developed for targeted therapy in diseases, among which some representative compounds have entered clinical trials. Therefore, this review aims to provide a summary of the structural characteristics, signaling pathways of P38MAPK and the relationship between p38MAPK and disease, along with an overview of the binding modes and structure–activity relationships of small molecule inhibitors targeting four p38MAPK subtypes, and summarizes the challenges about the development of p38MAPK inhibitors, hoping to provide a valuable reference for the development and application of novel inhibitors.
How previous experiences shape actors' current perspectives in integrated natural resource management
Authors: Gaus Raphael , Ejderyan Olivier , Grêt‐Regamey Adrienne , Leach William D. , Buchecker Matthias 
Published: September 2023

Abstract

Previous experiences play a multifaceted role in shaping current perspectives in integrated natural resource management. We used qualitative interviews and a quantitative survey to study the similarities and differences in terms of the links between the diverse actors' previous experiences and their current perspectives on the various issues to be resolved in a real‐world integrated watershed management project.

We found that the quantity and quality of experiences in past projects including water management, participation and politics are dissimilarly linked to the information, mental models and beliefs of perspectives regarding present issues. More experienced actors generally have broader perspectives than less experienced actors. Less experienced actors are particularly curious about approaches to water management.

Actors with more experience in water management are more focused on ecological issues due to positive experience. Actors with more experience in participation are more sceptical about constructive solutions due to negative experience. Actors with more experience in politics emphasise the importance of agriculture and learning processes due to positive or negative experience. Actors with more negative experience in water management, participation and politics can nevertheless be motivated for participatory processes and integrated natural resource management.

We conclude that previous experiences are critical factors that should be considered when designing participatory processes in integrated natural resource management. It could be valuable to include mixed compositions of actors with different types of previous experiences and different aspects of current perspectives to benefit from their complementary strengths.

Read the free Plain Language Summary for this article on the Journal blog.
Polymer blend templated hierarchical porous composites with segregated structure and enhanced electromagnetic interference shielding performance
Authors: Li Yilong , Song Danyang , Chen Quanpeng , Liu Yujie , Zheng Yanjun , Nie Cong , Jia Yunchao , Zheng Hongjuan , Wei Fengchun 
Published: September 2023

AbstractConductive network built by less conductive filler is vital for high‐performance conductive polymer composites. Herein, porous ultrahigh molecular weight polyethylene (UHMWPE)/poly(vinylidene fluoride) (PVDF) blends filled with multi‐walled carbon nanotubes (MWCNT) were fabricated, where poly(lactic acid) (PLA) and polymethyl methacrylate (PMMA) were served as sacrificial template. An interconnecting conductive network is formed based on the UHMWPE segregated structure and PVDF co‐continuous structure in porous UHMWPE/PVDF/MWCNT (UFC) composites. The UFC composites demonstrate a low electrical percolation threshold (0.25 wt%) due to the segregated/co‐continuous structure. Porous UFCs exhibit higher electromagnetic interference shielding effectiveness (EMI SE) than their compact counterparts. The blend‐templated porous structure enhances the EMI SE of composites because a well‐dispersed and densely packed MWCNT network is formed around the polymer particles, facilitating the multiple reflections of electromagnetic waves inside the composites. This effort provides a facile way for preparing high‐performance shielding materials by controlling the hierarchical structure and conductive filler distribution.Highlights
Hierarchical porous structure was constructed by blend sacrificial templating method.
Carbon fillers are exclusively distributed at blend interface, forming the segregated structure.
Porous composites exhibit better shielding performances than their solid counterparts.
Radiotherapy May Exacerbated Anti-Programmed Cell Death 1 Treatment Induced Vitiligo: A Case Report
Authors: Chen Chengqian , Chang Qihang , Wang Bo , Wang Yaqi , Zhang Zhen , Wang Xiuli 
Published: September 2023

Abstract
Immunotherapy with programmed cell death 1 (PD-1) checkpoint inhibitors combined with chemoradiotherapy shows great potential for cancer treatment and is getting extensively researched. However, a plethora of immune-related adverse events (irAEs) has been observed during anti-PD-1 treatment, including cutaneous adverse events, such as vitiligo and pruritus. These adverse events may lead to treatment discontinuation. When anti-PD-1 treatment is combined with radiotherapy (RT), irAEs may be exacerbated. Here we present a case report of an elderly patient with stage IIIb rectal cancer, who developed PD-1 inhibitor-associated vitiligo. After a session of RT, vitiligo lesions enlarged shortly thereafter. After discontinuation of anti-PD-1 treatment, vitiligo lesions and pruritus quickly improved with appropriate treatment. The rectal cancer achieved clinical complete response with no sign of recurrence or metastasis during follow-up. Considering the similar mechanism of anti-PD-1 treatment in targeting cancer and in inducing irAEs, cutaneous adverse events may be associated with favourable clinical response. Additionally, cutaneous irAEs aggravated by RT in this patient may suggested significant immune activation, which may occasionally contribute to tumour regression and favourable clinical outcome.
On the Ion Coordination and Crystallization of Metal Halide Perovskites by In Situ Dynamic Optical Probing
Authors: Zeng Zixin , Wang Yunfan , Xie Yue‐Min , Zhu Zhaohua , Yang Yajie , Ma Yuhui , Hao Xia , Lee Chun‐Sing , Cheng Yuanhang , Tsang Sai‐Wing 
Published: September 2023

AbstractControlling the crystallization to achieve high‐quality homogeneous perovskite film is the key strategy in developing perovskite electronic devices. Here, an in situ dynamic optical probing technique is demonstrated that can monitor the fast crystallization of perovskites and effectively minimize the influence of laser excitation during the measurement. This study finds that the typical static probing technique would damage and induce phase segregation in the perovskite films during the excitation. These issues can be effectively resolved with the dynamic probing approach. It also found that the crystallization between MAPbI3 and MAPbI2Br is strikingly different. In particular, MAPbI2Br suffers from inefficient nucleation during the spin‐coating that strongly affects the uniform crystal growth in the annealing process. The commonly used pre‐heating process is found at a lower temperature not only can further promote the nucleation but also to complete the crystallization of MAPbI2Br. The role of further annealing at a higher temperature is to facilitate ion‐dissociation on the crystal surface to form a passivation layer to stabilize the MAPbI2Br lattices. The device performance is strongly correlated with the film formation mechanism derived from the in situ results. This work demonstrates that the in situ technique can provide deep insight into the crystallization mechanism, and help to understand the growth mechanism of perovskites with different compositions and dimensionalities.
Software‐in‐the‐loop simulation for developing and testing carbon‐aware applications
Authors: Wiesner Philipp , Steinke Marvin , Nickel Henrik , Kitana Yazan , Kao Odej 
Published: September 2023

AbstractThe growing electricity demand of IT infrastructure has raised significant concerns about its carbon footprint. To mitigate the associated emissions of computing systems, current efforts therefore increasingly focus on aligning the power usage of software with the availability of clean energy. To operate, such carbon‐aware applications require visibility and control over relevant metrics and configurations of the energy system. However, research and development of novel energy system abstraction layers and interfaces remain difficult due to the scarcity of available testing environments: Real testbeds are expensive to build and maintain, while existing simulation testbeds are unable to interact with real computing systems. To provide a widely applicable approach for developing and testing carbon‐aware software, we propose a method for integrating real applications into a simulated energy system through software‐in‐the‐loop simulation. The integration offers an API for accessing the energy system, while continuously modeling the computing system's power demand within the simulation. Our system allows for the integration of physical as well as virtual compute nodes, and can help accelerate research on carbon‐aware computing systems in the future.
Pathogenomics model for personalized medicine in cervical cancer: Cross‐talk of gene expressions and pathological images related to oxidative stress
Authors: Li Jiaqi , Chen Siyi , Wu Junsong , Liu Xuefeng , Liu Hejing , Liu Yuedong , Zhu Zhuoying 
Published: September 2023

AbstractAn increasing number of studies have shown that oxidative stress plays an important role in the development and progression of cancer. Cervical cancer (CC) is a disease of unique complexity that tends to exhibit high heterogeneity in molecular phenotypes. We aim here to characterize molecular features of cervical cancer by developing a classification system based on oxidative stress‐related gene expression profiles. In this study, we obtained gene expression profiling data for cervical cancer from the TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) (GSE44001) databases. Oxidative stress‐related genes used for clustering were obtained from GeneCards. Patients with cervical cancer were divided into two subtypes (C1 and C2) by non‐negative matrix factorization (NMF) classification. By performing Kaplan–Meier survival analysis, differential expression analysis, and gene set enrichment analysis (GSEA) between the two subtypes, we found that subtype C2 had a worse prognosis and was highly enriched for immune‐related pathways as well as epithelial‐mesenchymal transition (EMT) pathways. Subsequently, we performed metabolic pathway analysis, gene mutation landscape analysis, immune microenvironment analysis, immunotherapy response analysis, and drug sensitivity analysis of the two isoforms. The results showed that the isoforms were significantly different between metabolic pathway enrichment and the immune microenvironment, and the chromosomes of subtype C1 were more unstable. In addition, we found that subtype C2 tends to respond to treatment with anti‐CTLA4 agents, a conclusion that coincides with high chromosomal variation in C1, as well as C2 enrichment of immune‐related pathways. Then, we screened 10 agents that were significantly susceptible to C2 subtype. Finally, we constructed pathogenomics models based on pathological features and linked them to molecular subtypes. This study establishes a novel CC classification based on gene expression profiles of oxidative stress‐related genes and elucidates differences between immune microenvironments between CC subtypes, contributing to subtype‐specific immunotherapy and drug therapy.
A boosted muon collider
Authors: Barducci Daniele , Strumia Alessandro 
Published: September 2023

Abstract
A muon collider could produce the heavier Standard Model particles with a boost, for example in resonant processes such as μ−μ+→ h or μ−μ → Z. We propose machine configurations that produce the boost (asymmetric beam energies, tilted beams) and estimate how much the luminosity is reduced or perhaps enhanced. The feasibility of the proposed configurations, as well as an estimation of the beam-induced backgrounds and beam energy spread, needs to be evaluated in order to derive more solid conclusions on the physics potential of such boosted collider configurations. If achievable, the boost can provide new interesting observational opportunities. For example it can significantly enhance the sensitivity to long-lived new particles decaying in a far-away detector, such as dark higgses or sterile neutrinos produced in h or Z decays.