bluuebunny/crossref_metadata_2025_split huggingface dataset:
“My young life, finished already?”: A qualitative study of embedded social stressors and their effects on mental health of low-wage migrant workers in Singapore
Authors: Farwin Aysha , Low Amanda , Howard Natasha , Yi Huso 
Published: May 2023

Abstract
Background Increasing evidence shows low-wage migrant workers experience a high prevalence of mental health disorders and adverse health outcomes. Significant disparities in health services usage among migrant workers create added vulnerability to health complications. However, much remains unclear about how vulnerabilities are constructed in migrant worker populations. Additionally, no studies in Singapore have attempted to critically examine the degree to which social environment and structures affect the health and wellbeing of migrant workers. Therefore, this study aimed to critically situate the socio-structural factors creating conditions of vulnerability among migrant workers using a social stress perspective.Methods We conducted 21 individual semi-structured interviews and two group interviews with migrant workers focused on individual life experiences, community experiences (individual and collective social capital), health (mental and physical health concerns) and stress response behaviours. We used a grounded theory approach to identify sources of stress and stress responses and uncover pathways to social vulnerabilities.Results Migrant workers were embedded in a cycle of chronic stress driven by structural factors that were mutually reinforced by stressors arising from their social environment. Socio-structural stressors enacted as poor living, working and social conditions resulted in their negative quality-of-life appraisal. Stressors arising from being “foreign” resulted in anticipated stigma, concealment, and healthcare avoidance. These factors synergistically created a persistent mental health burden for migrant workers.Conclusions Findings highlight the need to address the mental health burden placed on migrant workers and create avenues for migrant workers to seek psychosocial support to manage their stressors.
Systemic Bioinformatics computational analysis of Hazard Ratio (HR) level of RNA-binding proteins in human Breast, Colon and Lung cancer
Authors: Bakheet Tala , Al-Ahmadi Wijdan , Al-Mutairi Nada , Doubi Mosaab , Alhosaini Khaled , Al-Zoghaibi Fahad 
Published: May 2023

Abstract
Breast, colon and lung carcinomas are classified as aggressive tumors that have poor relapse-free survival (RFS) or progression-free survival (PF) and poor hazard ratios (HRs) despite of extensive therapy. Therefore, it is essential to identify a gene expression signature correlating with RFS/PF and HR status to predict the efficiency of treatment. RNA Binding Proteins (RBPs) play a critical role in RNA metabolic activities including RNA transcription, maturation and posttranslational regulation. However, their particular involvement in cancers is not yet understood. In this study, we used computational bioinformatics to classify the function and the correlation of RBPs among solid cancers. We aimed to identify the molecular biomarker that would help in disease prognosis prediction or improve therapeutic efficiency in treated patients. The intersection analysis summarized more than 1659 RBPs across three recently updated RNA databases. The bioinformatics analysis showed that 58 RBPs were common in breast, colon and lung cancers with HR values < 1 and > 1 and a significant Q-value < 0.0001. RBP gene clusters were identified based on RFS/PF, HR, P-value and fold of induction. In order to define union RBPs, the common genes were subjected to hierarchical clustering and classified into two groups. Poor survival with high-risk HR genes included CDKN2A, MEX3A, RPL39L and VARS (valine cytoplasmic-localized aminoacyl-tRNA synthetase) and poor survival with low-risk HR genes included GSPT1, SNRPE, SSR1 and TIA1, PPARGC1B, EIF4E3 and SMAD9. This study may highlight the significant contribution of the 11 RBP genes as prognostic predictors in breast, colon and lung cancer patient and their potential application in personalized therapy.
Translocation, residues and risk assessment of thiamethoxam applied by root irrigation in tomato plant ecosystems
Authors: Li Li , Liang Hongwu , Pan Wei , Yin Shijie , Cao Junli , Li Jindong 
Published: May 2023

Abstract
Thiamethoxam (TMX) has been registered for use on a wide range of crops due to its broad pest spectrum, high efficiency and versatile application methods. However, there is limited literature evaluating the residue behaviors of TMX applied through root irrigation. In this study, the uptake and translocation of TMX, its degradation to clothianidin (CLO) and risk assessment of TMX application in a tomato plant ecosystem were evaluated. TMX applied through root irrigation was transferable within the tomato plant, including stems, leaves and fruit at different heights. TMX concentration in the four sections of stems was ordered as Clower > Cmid > Cupper > Ctop, while in the leaves the order was the opposite and the top had the highest concentration. The degradation product CLO was detected in the tomato plant, and the concentration order was Cleaf > Croot > Cstem > Ctomato. In the leaves, the concentrations of CLO were even higher than those of TMX. The translocation factor (TF) in the same section generally followed the order of TFleaf > TFstem > TFtomato. Both long-term and short-term risks were lower than 0.44% for all the subgroups in China, which indicated that the application of TMX was comparably acceptable. This study promotes the evaluation of TMX applied through root irrigation for use in tomato ecosystems from a dietary safety perspective.
Observation of large spin-polarized Fermi surface of a magnetically proximitized semiconductor quantum well
Authors: Anh Le Duc , Shiratani Harunori , Takiguchi Kosuke , Tanaka Masaaki 
Published: May 2023

Abstract
The magnetic proximity effect (MPE) in bilayers of a nonmagnetic (NM) conductive layer and a ferromagnetic (FM) insulator attracts much attention as a promising way for introducing ferromagnetism into a NM channel. Although the range of MPE is limited to only a few atomic layers from the interface, it is extended to several tens of nm in high-quality semiconductor bilayers consisting of a NM quantum well (QW) and an underlying ferromagnetic semiconductor layer, leading to the discovery of large gate-controllable proximity magnetoresistance. In order to elucidate the microscopic mechanism of this long-range MPE and realize its device applications, it is essential to directly observe the magnetically proximitized electronic structure of the NM semiconductor, but it is still lacking. Here, by investigating the Shubnikov-de Haas oscillations in NM InAs QW / FM (Ga,Fe)Sb bilayers, we successfully observe the spin-polarized Fermi surface of the InAs QW. The spontaneous spin-splitting energy in the conduction band of the InAs QW is found to reach 6.3 meV when applying a negative gate voltage, which is the largest spin splitting via MPE ever reported. This highly gate-tunable spin-polarized Fermi surface of a magnetically proximitized InAs QW provides an ideal platform for novel spintronic and topological devices.
Analytic model for the transmission and reflection in two cascaded stages of fiber Bragg grating
Authors: ali hosam A.M. , Mohra Ashraf S. , Hussein Khalid F. A. 
Published: May 2023

Abstract
The fundamental issue limiting long-distance and high-speed optical fiber transmission is dispersion. Dispersion impairs system performance, the signal-to-noise ratio (SNR), and the bit error rate (BER). To address this, numerous dispersion modification techniques have been developed. The use of fiber Bragg grating (FBG) is one of the efficient strategies for dispersion compensation. The FBG is frequently used as a filter. The proposed model uses uniform fiber Bragg grating UFBG. Two cascaded FBGs with varying lengths, a constant grating period, and a constant spacing between FBGs are employed in the proposed thesis. The input signal for the stage that follows is the output signal from the previous stage. The best performance and many applications are considered while modeling, analyzing, and comparing this system. Transmission and reflection in two cascaded stages of fiber Bragg grating using first and second order are studied. The mathematical equations for the proposed model are simulated in MATLAB.
Electrocardiogram Feature Based Heart Arrhythmia Detection Using Machine Learning and Apache Spark
Authors: Singhal Prateek , Yadav Rakesh Kumar 
Published: May 2023

Abstract
Heart arrhythmias are the main cause of death worldwide. Electrocardiogram (ECG) results can be used to identify arrhythmias, or irregularities in the heart's rhythm. Because symptoms are not always present, the diagnosis is often off. To prevent a potentially catastrophic situation, patients using real-time ECG monitoring must identify arrhythmias early on. In this work, Structured Streaming, an open-source Apache Spark technology, was used. Finding a method to apply machine learning to detect cardiac arrhythmias in real-time is the goal of the project. Investigating how structured streaming affects metrics for content classification and how long it takes to find episodes was another goal. At MIT and BIH, we have been gathering ECG information. With this information, arrhythmias like RBBB and atrial fibrillation might be recognised and categorised. There are many methods for separating these erratic rhythms from one another. We used a multiclass classifier based on logistic regression, a random forest, and three different decision trees to categorise the data. The random forest classifier wins out when the three classification methods are compared. In comparison to other studies, this study demonstrated improved classification model performance metrics and decreased pipeline runtime.
Developing content-valid tumor-specific PRO-CTCAE item sets: analysis of a cross-sectional survey in three German outpatient cancer centers
Authors: Günther Maximilian , Hentschel Leopold , Schuler Markus , Müller Theresa , Schütte Katharina , Ko Yon-Dschun , Schmidt-Wolf Ingo , Jaehde Ulrich 
Published: May 2023

Abstract
Background
To include the patient perspective in the assessment of adverse events (AE) in oncology, a patient-reported outcomes (PRO) version of the Common Terminology Criteria for Adverse Events (CTCAE) was developed by the NCI, the so called PRO-CTCAE. The objective of this study was the development of disease-specific PRO-CTCAE item sets with high content validity for patients with breast cancer (BC), multiple myeloma (MM) and prostate cancer (PC).
Methods
A cross-sectional survey was conducted at three German outpatient cancer centers. Prevalence and importance of the 78 PRO-CTCAE symptoms were assessed using a patient questionnaire. To select the most relevant PRO-CTCAE items for each tumor entity, symptoms were ranked based on patient answers.
Results
101 patients with BC, 107 with MM, and 66 with PC participated. The final item sets contained 21 symptoms (BC) or 19 symptoms (MM and PC), respectively. Eight symptoms were represented in all three item sets. Fatigue was the symptom with the highest ranking across item sets followed by sleep disorders. Symptoms with the highest rankings represented in only one item set were symptoms affecting the urogenital system in the PC item set, blurred vision in the BC item set and appetite loss in the MM item set.
Conclusions
Individual PRO-CTCAE item sets with high content validity were developed for three tumor diseases on the basis of patient-reported symptom patterns and perceptions. The quality and psychometric criteria of the newly compiled item sets should be further validated.
Sensory nerves directly promote osteoclastogenesis by secreting Peptidyl-prolyl cis-trans isomerase D (Cyp40)
Authors: Pei Guo-xian , Yang Liu , Liu Bin , Wu Hao , zhang shuaishuai , liang zhuowen , guo shuo , jiang huijie , song yue , cheng pengzhen , li donglin , wang jimeng , liu yang , Wang Di , Xiao Guozhi , lei xing , gao yi , Zhan Nazhi , Xu Jing , Wang Lin , Li Junqin 
Published: May 2023

Abstract
Given the afferent functions, sensory nerves recently have been found exerting efferent influences and directly alter organ physiology. Moreover, studies have demonstrated the crucial role of sensory nerves in the physiological function of osteoclasts. However, the direct evidence of whether sensory nerve efferent influences osteoclast, remains lacking. Here, we found abundant efferent signals transported from sensory nerves into osteoclasts; sensory hypersensitivity significantly increased osteoclastic bone resorption; and sensory neurons (SN) directly promote osteoclastogenesis in vitro co-culture system. Then our screening identified a novel neuropeptide Cyp40, is the efferent signal from the sensory nerve and plays a critical role in the osteoclastogenesis, via aryl hydrocarbon receptor (AhR)-Ras/Raf-pErk-NFATc1 pathway. These findings revealed a novel mechanism of sensory nerves on bone regulation: the direct promotion of osteoclastogenesis by secreting Cyp40. Inhibiting the Cyp40 could therefore be a strategy to improve bone quality in osteoporosis and promote bone repair after bone injury.
GeO 2 nanoparticles loaded reduced graphene oxide aerogel as a lithium-ion battery anode
Authors: Cakmak Oznur Kaya 
Published: May 2023

Abstract
Germanium dioxide/reduced graphene oxide (GeO2/rGO) composite aerogel is synthesized by using supercritical drying method. rGO and composite aerogel show high specific surface area. In addition, as an anode material for lithium-ion batteries (LIBs), the composite aerogel exhibits a good capacity retention after 500 cycles. The outstanding characteristics of non-aggregated graphene and homogeneously dispersed GeO2 nanoparticles in the rGO/GeO2 aerogel account for the noticeable electrochemical properties. The application of the rGO/GeO2 electrode indicated in this study is estimated to encourage the development of affordable carbon-based materials for LIBs anode applications.
Psychometric Properties and Validation of the Polish Version of the Fibromyalgia Impact Questionnaire (FIQ-Pol)
Authors: Ćwirlej-Sozańska Agnieszka , Sozański Bernard , Łyko Aleksandra , Łagowska Anna , Leszczyńska Natalia , Kuduk Barbara , Wilmowska-Pietruszyńska Anna 
Published: May 2023

Abstract
Background: Fibromyalgia (FM) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, intestinal disorders, mood swings, and sleep disturbances. To the best of our knowledge, the questionnaire used for assessing problems and difficulties in the functioning of people with FM has not been translated and adapted in Poland so far. The aim of the study was to assess the psychometric properties of the Polish version of the Fibromyalgia Impact Questionnaire (FIQ-Pol).
Material and method: The study covered 150 people with FM living in Poland. We have studied the measurement reliability, internal structure, repeatability and validity of the Polish version of the FIQ.
Results: The scale score reliability of the entire tool for the research group was very good. The alpha Cronbach's test result for the whole scale was 0.84. The repeatability of the scale measured by the test-retest method using the interclass correlation coefficients (ICC) was very good and amounted to 0.96. Internal structure suggested by FIQ authors was confirmed (confirmatory factor analysis). After introducing modification indices for the entire scale, satisfactory parameter values were obtained, i.e.: RMSEA (0.06), CFI (0.97) and TLI (0.96). Theoretical validity was assessed by correlating the results of the Polish version of the FIQ with the results of the Beck's Depression Inventory (BDI). Both the FIQ-Pol total score and its domains showed strong positive correlations with BDI.
Conclusion: The Polish FIQ is a reliable and valid tool to measure the functional disability and health status of Polish people with FM.
Late-onset cblC defect: clinical, biochemical and molecular analysis
Authors: Ding Si , Ling Shiying , Liang Lili , Qiu Wenjuan , Zhang Huiwen , Chen Ting , Zhan Xia , Xu Feng , Gu Xuefan , Han Lianshu 
Published: May 2023

Abstract
Background
cblC defect is the most common type of methylmalonic acidemia in China. Patients with late-onset form (>1 year) are often misdiagnosed due to heterogeneous symptoms. This study aimed to describe clinical characteristics and evaluate long-term outcomes of Chinese patients with late-onset cblC defect.
Methods
A total of 85 patients with late-onset cblC defect were enrolled. Clinical data, including manifestations, metabolites, molecular diagnosis, treatment and outcome, were summarized and analyzed. Logistic regression was used to analyze the factors influencing the prognosis of patients.
Results
The median age at disease onset and median time delay from initial symptoms to diagnosis were about 8.6 years old (ranging from 2 to 32.8 years old) and 2 months (ranging from few days to 20 years), respectively. Patients with late-onset cblC defect presented neuropsychiatric symptoms (68.2%), renal involvement (20.0%), cardiovascular disease (8.2%) and metabolic crises (3.5%) as first symptoms, which seemed to be age-associated. Disease progressed in most patients. Overall, cognitive decline is the most frequent symptom. The level of propionylcarnitine, propionylcarnitine / acetylcarnitine ratio, methylmalonic acid, methylcitric acid and homocysteine, were decreased remarkably after treatment( (P<0.001). 24 different mutations of MMACHC were identified in 78 patients, of which two were novel. The c.482G >A was the most frequent mutated alleles in this cohort (25%). Except 16 patients were completely recovered, the remaining patients still left with various severities of sequel in a long-term follow-up. The available data of 76 cases were analyzed by logistic regression, and the results showed that the time from onset of symptoms to diagnosis was significantly associated with the prognosis of patients (P < 0.05).
Conclusions
The diagnosis of late-onset cblC defect is often delayed due to poor awareness of its various and nonspecific symptoms, thus leading to a significant disability. It should be considered in patients with unexplained neuropsychiatric, renal and cardiovascular diseases or even multiple organ damage. Early diagnosis and prompt initiation of therapy are essential for the improvement of prognosis.
Oral mycotic infection caused by a rare Verticillium species – a case report
Authors: Habib Saqib , Naved Nighat , Awan Sohail 
Published: May 2023

Abstract
Background:
Deep-seated fungal infections of the oral cavity present a diagnostic challenge as the clinical presentation is usually aggressive leading to misdiagnosis of malignancy. Nevertheless, the species of fungi responsible for such diseases in immunocompromised individuals are varied thus, further complicating the diagnosis.
Case presentation:
Presented below is a case regarding the diagnosis and management of deep mycotic infection of the oral cavity caused by a fungus that very rarely causes disease in humans, theVerticillium species.
Conclusions:
The case highlights the fact that rare pathogens should also be considered in the differential diagnosis, especially in patients with debilitating conditions like uncontrolled diabetes. Likewise, histopathological evaluation is of paramount importance and remains the gold standard to reach a definitive diagnosis.
Fenofibrate suppresses the progression of hepatoma by inhibiting PI3K/AKT/Twist pathway through downregulating Osteopontin
Authors: Chen Weiqing , Chen Feihua , Gong Mouchun , Ye Lijun , Weng Dengcheng , Jin Zhaoqing , Wang Jianjiang 
Published: May 2023

Abstract
Primary hepatic carcinoma (PHC) is a leading threat to cancer patients with few effective treatment strategies. OPN is found to be an oncogene in hepatocellular carcinoma (HCC) with potential as a treating target for PHC. Fenofibrate is a lipid-lowering drug with potential anti-tumor properties, which is claimed with suppressive effects on OPN expression. Our study proposes to explore the molecular mechanism of fenofibrate in inhibiting HCC. OPN was found extremely upregulated in 3 HCC cell lines, especially Hep3B cells. Hep3B cells were treated with 75 and 100 µM Fenofibrate, while OPN-overexpressed Hep3B cells were treated with 100 µM Fenofibrate. Hep3B xenograft model was established, followed by treated with 100 mg/kg and 200 mg/kg Fenofibrate. OPN-overexpressed Hep3B xenograft model was established, followed by treated with 200 mg/kg Fenofibrate. Decreased clone number, elevated apoptotic rate, reduced number of migrated cells, shortened migration distance, and suppressed tumor growth in xenograft model were observed by the administration of Fenofibrate, which were markedly abolished by the overexpression of OPN. Furthermore, the inhibitory effect of Fenofibrate on the PI3K/AKT/Twist pathway in Hep3B cells and Hep3B xenograft model was abrogated by OPN overexpression. Collectively, Fenofibrate suppressed progression of hepatoma by inhibiting PI3K/AKT/Twist pathway through downregulating OPN.
Skin lesions by Scedosporium apiospermum and Nocardia pulmonary infection in an oncologic patient: A case report
Authors: Gavalda Meritxell , Lorenzo Alejandro , Vilchez Helem , Gimenez Sandra , Calvo Cristina , Martin Luisa , Riera Melchor 
Published: May 2023

Abstract
Background Fungal infections are an uncommon entity, especially those produced by species other than Aspergillus. Despite this, they are usually more virulent and difficult to treat. In the following case report, we present the case of an immunocompromised patient suffering from two serious opportunistic infections in the same episode: the first of these, Nocardia multilobar pneumonia; and the second, skin infection by Scedosporium apiospermum. These required prolonged antibacterial and antifungal treatment.Case presentation This case is a 71 year-old oncological patient admitted for recurrent pneumonias that was diagnosed for Nocardia pulmonary infection. Nervous system involvement was discarded and cotrimoxazol was started. Haemorrhagic skin ulcers in the lower limbs appeared after two weeks of hospital admission. We collected samples which were positive for Scedosporium apiospermum and we added voriconazole to the treatment. As a local complication, the patient presented a deep bruise that needed debridement. We completed 4 weeks of intravenous treatment with slow improvement and continued with oral treatment until the disappearance of the lesions occurs.Conclusions Emerging fungal infections such as Scedosporium apiospermum are increasing globally. These species are more difficult to diagnose and treat, due to factors of the fungus itself and the characteristics of the patient, and therefore clinicians must be aware of their complications.
Isolated Collagenoma Mimicking a Lipoma in an HIV-positive Patient on HAART: a Case Report
Authors: Wu Kevin , Movassaghi Masoud , DeClerck Brittney , Chow Maggie 
Published: May 2023

Abstract
Background
Collagenomas are connective tissue hamartomas composed of dermal collagen. Patients infected with human immunodeficiency virus (HIV) can present with HIV-related lipodystrophy or lipomas. There are no known associations between HIV and collagenomas.
Case Presentation
Here we describe a case of an isolated collagenoma mimicking lipodystrophy in an HIV patient that developed following initiation of highly active antiretroviral therapy (HAART). The lesion was a seven by four-centimeter subcutaneous nodule with no epidermal changes located on the occipital scalp. This lesion was excised, and histopathology showed thick and randomly arranged collagen bundles, consistent with a collagenoma.
Conclusion
This case represents an isolated collagenoma presenting in a patient with HIV. Treatment of collagenomas include surgical excision and intralesional corticosteroids. It is important to keep collagenoma in the differential diagnosis in a patient presenting with an isolated large indurated subcutaneous nodule.