bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcutaneous emphysema and pneumomediastinum following orbital blowout pathological fracture in a cat with nasal lymphoma: a case report
Authors: Oh Ye-In , Hong Heejeong , Kim Tae-hee , Kang Kyuyong , Yoon Junghee , Youn Hwa-Young , Seo Kyoung-Won 
Published: September 2023

Abstract
Background
Subcutaneous emphysema and pneumomediastinum are rare complications associated with orbital blowout pathological fracture.

Case presentation
A 7-year old, castrated male Abbysinian cat presented with anorexia, lethargy, nausea, eyelid swelling, nasal discharge, and sneezing. Based on the clinical and diagnostic work-up, the cat was diagnosed with T cell high-grade nasal lymphoma associated with orbital pathological fracture due to the tumour invasion. After chemotherapy, the cat showed massive subcutaneous emphysema from frontal region to abdomen and pneumomediastinum due to orbital blowout pathological fracture. As the nasal mass decreased in volume; the air had moved from the maxillary sinus to the subcutaneous region and the mediastinum through fascial planes in the head and neck region.

Conclusions
This is a first case report of a massive subcutaneous emphysema and pneumomediastinum due to an orbital blowout pathological fracture following chemotherapy in feline nasal lymphoma in veterinary medicine.
Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
Authors: Furkert Chris , Martin Richard , Sharma Avinash , Rivalland Gareth 
Published: September 2023

AbstractThis report describes the case of a 70-year-old man with metastatic squamous cell carcinoma (SCC) of the right lower leg. Soon after definitive surgical management of the primary and nodal metastases with curative intent, he relapsed, developing aggressive in-transit metastatic disease and recurrent nodal disease. The patient was treated with systemic immunotherapy alone, which not only prompted the progressive nodal metastases to regress, but also resulted in a complete response of the in-transit disease. This situation is previously undescribed in the medical literature.
Lemierre’s syndrome complicating deep neck abscess: a case report
Authors: Xu Yi , Shi Qingyuan , Ying Haiyue 
Published: September 2023

Abstract
Background
Lemierre’s Syndrome is a severe medical condition that can result from oropharyngeal infection, typically caused by Fusobacterium necrophorum, leading to sepsis, internal jugular vein thrombosis, and metastatic septic emboli. However, there is limited literature on this syndrome caused by Streptococcus anginosus, and few previous cases have been reported to have deep neck space infection. We present the first case of Lemierre’s Syndrome caused by Streptococcus anginosus with deep neck abscess.

Case presentation
A 53-year-old male patient with no significant medical history presented with right neck pain after accidentally swallowing a fish bone one month ago. Laryngoscopy did not reveal any abnormalities. Five days prior to admission, the patient developed high fever. Imaging studies showed internal jugular vein thrombosis and a neck abscess surrounding the carotid artery sheath. Blood culture results were positive for Streptococcus anginosus infection, and the patient was diagnosed with Lemierre’s syndrome. The patient underwent surgical drainage and received antibiotics and anticoagulant therapy, and had satisfactory clinical progress. He was discharged after a 16-day hospitalization.

Conclusions
Although Lemierre’s syndrome is rare, it needs attention because it can lead to serious complications and requires timely treatment. Deep neck space infections can be life-threatening and doctors must be aware of its potential severity.
Analysis of factors associated with the failure of treatment in thoracolumbar burst fractures treated with short-segment posterior spinal fixation
Authors: Alimohammadi Ehsan , Bagheri Seyed Reza , Joseph Benson , Sharifi Hasti , Shokri Bita , Khodadadi Lida 
Published: September 2023

Abstract
Background
The treatment of thoracolumbar burst fractures continues to pose challenges. Although short-segment posterior spinal fixation (SSPSF) has shown satisfactory clinical outcomes, it is accompanied by a relatively high rate of treatment failure. This study aimed to assess factors associated with treatment failure in thoracolumbar burst fractures treated with SSPSF.

Methods
The clinical data of 241 consecutive patients with a traumatic thoracolumbar burst fracture who underwent SSPSF at our center between Apr 2016 and Apr 2021 were retrospectively reviewed. Patients were divided into two groups (failure of the treatment group and non-failure of the treatment group). We compared potential risk factors for the failure of treatment including age, gender, body mass index, smoking, diabetes, vertebral body compression rate, use of crosslinks, percentage of anterior height compression, presence of index level instrumentation, Cobb angle, interpedicular distance (IPD), canal compromise, Load Sharing Classification (LSC) score, use of posterolateral fusion, and pain intensity between the two groups.

Results
A sum of 137 (56.8%) males and 104 (43.2%) females were enrolled where the mean age and follow-up of the participants were 48.34 ± 10.23 years and 18.67 ± 5.23 months, respectively. Treatment failure was observed in 34 cases (14.1%). The results of the binary logistic regression analysis revealed that the lack of index level instrumentation (OR 2.21; 95% CI 1.78–3.04; P = 0.014), LSC score (odds ratio [OR] 2.64; 95% confidence interval [95% CI], 1.34–3.77; P = 0.007), and IPD (OR 1.77; 95% CI 1.51–2.67; P = 0.023) were independently associated with a higher rate of failure of treatment.

Conclusions
The findings of this study revealed that increased rates of treatment failure in thoracolumbar burst fractures treated with SSPSF were associated with factors such as the absence of index level instrumentation, higher LSC scores, and larger IPD. These findings could be helpful in the proper management of patients with unstable thoracolumbar burst fractures.
A new reverse half-discrete Mulholland-type inequality with a nonhomogeneous kernel
Authors: Peng Ling , Abd Rahim Rahela , Yang Bicheng 
Published: September 2023

AbstractIn this paper, a new reverse half-discrete Mulholland-type inequality with the nonhomogeneous kernel of the form $h(v(x)\ln n)$
h
(
v
(
x
)
ln
n
)
and the best possible constant factor is obtained by using the weight functions and the technique of real analysis. The equivalent reverses are considered. As corollaries, we deduce some new equivalent reverse inequalities with the homogeneous kernel of the form $k_{\lambda }(v(x),\ln n)$

k
λ

(
v
(
x
)
,
ln
n
)
. A few particular cases are provided. Our new reverse half-discrete Mulholland-type inequality which has a nonhomogeneous kernel is more general than in the previous homogeneous kernel work. The harmonized integration will have more applications.
Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
Authors: Pomeshchik Yuriy , Velasquez Erika , Gil Jeovanis , Klementieva Oxana , Gidlöf Ritha , Sydoff Marie , Bagnoli Silvia , Nacmias Benedetta , Sorbi Sandro , Westergren-Thorsson Gunilla , Gouras Gunnar K. , Rezeli Melinda , Roybon Laurent 
Published: September 2023

AbstractThe hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mechanisms. To address this issue, we examined the cellular origin and progression of AD pathogenesis by comparing patient-based model systems including iPSC-derived brain cells transplanted into the mouse brain hippocampus. Proteomic analysis of the graft enabled the identification of pathways and network dysfunction in AD patient brain cells, associated with increased levels of Aβ-42 and β-sheet structures. Interestingly, the host cells surrounding the AD graft also presented alterations in cellular biological pathways. Furthermore, proteomic analysis across human iPSC-based models and human post-mortem hippocampal tissue projected coherent longitudinal cellular changes indicative of early to end stage AD cellular pathogenesis. Our data showcase patient-based models to study the cell autonomous origin and progression of AD pathogenesis.
Graphical Abstract
Thermophilic Moorella thermoacetica as a platform microorganism for C1 gas utilization: physiology, engineering, and applications
Authors: Jia Dechen , Deng Wangshuying , Hu Peng , Jiang Weihong , Gu Yang 
Published: September 2023

AbstractIn the context of the rapid development of low-carbon economy, there has been increasing interest in utilizing naturally abundant and cost-effective one-carbon (C1) substrates for sustainable production of chemicals and fuels. Moorella thermoacetica, a model acetogenic bacterium, has attracted significant attention due to its ability to utilize carbon dioxide (CO2) and carbon monoxide (CO) via the Wood–Ljungdahl (WL) pathway, thereby showing great potential for the utilization of C1 gases. However, natural strains of M. thermoacetica are not yet fully suitable for industrial applications due to their limitations in carbon assimilation and conversion efficiency as well as limited product range. Over the past decade, progresses have been made in the development of genetic tools for M. thermoacetica, accelerating the understanding and modification of this acetogen. Here, we summarize the physiological and metabolic characteristics of M. thermoacetica and review the recent advances in engineering this bacterium. Finally, we propose the future directions for exploring the real potential of M. thermoacetica in industrial applications.
Cardiac sarcoma presenting as paraneoplastic arthritis and clubbing: a case report and literature review
Authors: Ung Natasha , Gunasingam Carmella , Cai Ken , Manolios Nicholas , Bayly Angela , Dinh Phuong , Orr Yishay , Choudhary Preeti , Wong Peter 
Published: September 2023

Abstract
Background
Cardiac tumours are rare, and clinical manifestations depend on the anatomical location. Symptoms can be the result of cardiac outflow anomalies, constitutional features such as fever, loss of weight, and/or paraneoplastic manifestations such as arthritis. To date, there has only been one other case report in the literature of cardiac sarcoma presenting as paraneoplastic arthropathy.

Case presentation
A 52-year-old woman presented with acute onset corticosteroid-resistant inflammatory polyarthralgia, clubbing and a systolic murmur. Transthoracic echocardiogram revealed a dilated left atrium with an echogenic mass and brain magnetic resonance imaging revealed multiple embolic infarcts. Histopathology following emergency resection showed a Grade 3 left atrial intimal sarcoma. The polyarthralgia and clubbing resolved soon after tumour removal. The patient went on to receive chemotherapy and remains in remission.

Conclusions
This case highlights the rare paraneoplastic association of cardiac sarcoma and arthropathy.
The Arts of Antifascist Black Transnationalism during the Spanish Civil War
Authors: Truett Brandon 
Published: September 2023

Abstract
This article asserts the critical role of art and literature in the resistance against fascism by situating the aesthetic work of African Americans as central to the transnational phenomenon of the Spanish Civil War. This article highlights the prehistory to the African American support of the Spanish Civil War in 1936 when news of Benito Mussolini’s invasion of Ethiopia galvanized members of the Harlem Renaissance. These two conflicts triangulated the imaginaries of the United States, Spain, and Ethiopia, producing a distinct form of antifascist Black transnationalism that extends work by Brent Hayes Edwards, Robert F. Reid-Pharr, and Nadia Nurhussein. To manifest this argument, this article examines Paul Robeson’s speeches at rallies in London that he later reprinted in his autobiography Here I Stand (1958) and Claude McKay’s posthumously published novel Amiable with Big Teeth about 1936 Harlem. Using archival research, this article analyzes the collage aesthetic of the scrapbook that the activist Thyra J. Edwards compiled in 1937 to record the actions of the Negro People’s Committee to Aid Spain. In sum, this article demonstrates the integral role of African American visual culture and literature to the development of twentieth-century antifascist ideology within a transnational perspective.
Microlearning and Mobile Learning as a Response to the Challenges of Transformation of the Communication Environment of Modern Education
Authors: Kiuru K. , Popova E. , Agapov A. 
Published: September 2023

In modern society, communication on the Internet has completely changed the scenarios of human communication and education. Social networks provide access to information and global exchange of it, which poses new challenges to pedagogy as a science about the purpose and content of education. Internet pedagogy as a field of study and research activity explores the problems of the importance of the Internet for education and self-education, identifying the main forms of online learning, the relationship between the educational potential of the Internet and its actual use, the advantages and disadvantages of what users share online and what they learn with it.
Aim. To identify the attitude of students to education in social networks to confirm the relevance of microlearning and mobile learning as challenges to the transformation of the communication environment of modern education.
Methodology and research methods. To conduct the study, a questionnaire was developed, distributed using Google Forms. 466 university students from Chelyabinsk took part in the study. The sample type is spontaneous. The sampling contour is formed by registered users who have shown interest in this Internet survey. The mechanism for selecting respondents is self-selection.
Results. The communication environment of modern education is undergoing transformation, education with social networks is becoming more and more popular. The Russian market of educational services is not yet so acutely reacting to these transformations. We can predict that microlearning and mobile learning will become a serious alternative to the traditional educational environment in the coming years.
Scientific novelty. Analysis of the transformation of the communication environment of modern education allowed us to identify new trends - microlearning and mobile learning.
Practical significance. The identified trends will help the educational environment to prepare adequate responses to the identified challenges.
Debt Contracting When Borrowers Face Transitory Uncertainty: Evidence from U.S. Gubernatorial Elections
Authors: Kim Kirak , Nguyen Trang 
Published: September 2023

We study debt-contracting implications of uncertainty surrounding U.S. gubernatorial elections. In election years, loan contracts are more likely to include performance-pricing provisions, whereas loan spreads are mostly unaffected. Additionally, we find, only among those loans without performance-pricing provisions, a marginal increase in loan spreads in election years and a significant increase in loan-spread amendments postelection. The results suggest that under transitory uncertainty, performance pricing curbs an explicit rise in loan spreads and reduces ex-post renegotiations, yielding efficiency gains in contracting. Our further analysis uncovers a veiled pricing effect manifested through interest-rate contingencies: the likelihood of using rate-increasing pricing grids rises in election years for borrowers with a high exposure to uncertainty, thereby ensuring compensation to lenders for uncertainty. Overall, our findings suggest that loan contracting attempts to mitigate the problem of election uncertainty and renegotiation costs through state-contingent pricing, with which borrowers weigh initial loan spreads against the potential for loan-spread variability in the future. This paper was accepted by Victoria Ivashina, finance. Supplemental Material: The data is available at https://doi.org/10.1287/mnsc.2021.03106 .
A Localized Progressive Hedging Algorithm for Solving Nonmonotone Stochastic Variational Inequalities
Authors: Cui Xingbang , Zhang Liping 
Published: September 2023

The progressive hedging algorithm (PHA) is an effective solution method for solving monotone stochastic variational inequalities (SVIs). However, this validity is based on the assumption of global maximal monotonicity. In this paper, we propose a localized PHA for solving nonmonotone SVIs and show that its validity is based on the weaker assumption of locally elicitable maximal monotonicity. Furthermore, we prove that such assumption holds when the mapping involved in the SVI is locally elicitable monotone or locally monotone. The local convergence of the proposed algorithm is established, and it is shown that the localized PHA has the rate of linear convergence under some mild assumptions. Some numerical experiments, including a two-stage orange market problem and randomly generated two-stage piecewise stochastic linear complementarity problems, indicate that the proposed algorithm is efficient. Funding: This work was supported by the National Natural Science Foundation of China [Grant 12171271].
Root canal re-treatment. Part 1: why and when?
Authors: Dowling Nisha , Gemmell A , Bonsor Stephen J , Edwards D 
Published: September 2023

Both the anatomical challenges of root canal treatment and the variable clinical techniques employed mean that root canal re-treatment will sometimes be necessary. The first of this two-part series aims to discuss why cases may fail, and options for re-treatment. This includes the decision between re-treatment in general dental practice and the need for referral for specialist care.CPD/Clinical Relevance: Understanding the reasons for root canal treatment failure will reduce the likelihood of failure and enable appropriate assessment when it does happen.
Antibacterial study of carbopol-mastic gum/silver nanoparticle-based topical gels with carvacrol/neem bark extract in vitro
Authors: Zintle Mbese , Siwaphiwe Peteni , Marthe Carine Fotsing , Thierry Youmbi Fonkui , Derek Tantoh Ndinteh , Suprakas Sinha Ray , Blessing Atim Aderibigbe 
Published: September 2023

Background: Resistance to antimicrobial drugs as a result of prolonged use usually results in clinical failure, especially in wound infections. Development of effective antimicrobial therapeutics for the management of infected wounds from a natural source with improved therapeutic effects is a pressing need. Objective: In this study, carbopol-mastic gum-based topical gels were loaded with silver nanoparticles in combination with either neem bark extract or carvacrol oil. The effect of combining silver nanoparticles with neem bark extract or the essential oil carvacrol in the prepared gel formulations was investigated on selected bacterial strains. Method: The prepared gels were characterised by Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM) and ultraviolet–visible (UV–vis) spectroscopy, followed by antimicrobial analysis against selected strains of bacteria. Results: There was no interaction between the loaded natural extract or essential oil and the polymer used for the preparation of the formulations, which was visible from the FTIR spectra of the formulations. The gels were selective and effective against selected strains of bacteria. However, the combination of the silver nanoparticles with essential oil or natural extract in some of the gel formulations rendered the formulation ineffective against some of the bacterial strains. Conclusion: The gel formulations were effective against bacterial strains such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis which are the common causes of wound infections. Incorporation of silver nanoparticles into the topical formulations with natural extracts is usually a good approach to overcome antibiotic-resistant infections. However, the combination of antibacterial agents must be managed carefully.
The critical factors in producing high quality and policy-relevant research: insights from international behavioural science units
Authors: Lecouturier Jan , Vlaev Ivo , Chadwick Paul , Chater Angel M. , Kelly Michael P. , Goffe Louis , Meyer Carly , Tang Mei Yee , Antonopoulou Vivi , Graham Fiona , Sniehotta Falko F. 
Published: September 2023

Background:
There has been a rapid increase in the number of, and demand for, organisations offering behavioural science advice to government over the last ten years. Yet we know little of the state of science and the experiences of these evidence providers.
Aims and objectives:
To identify current practice in this emerging field and the factors that impact on the production of high-quality and policy-relevant research.
Methods:
A qualitative study using one-to-one interviews with representatives from a purposeful sample of 15 units in the vanguard of international behavioural science research in policy. The data were analysed thematically.
Findings:
Relationships with policymakers were important in the inception of units, research conduct, implementation and dissemination of findings. Knowledge exchange facilitated a shared understanding of policy issues/context, and of behavioural science. Sufficient funding was crucial to maintain critical capacity in the units’ workforces, build a research portfolio beneficial to policymakers and the units, and to ensure full and transparent dissemination.
Discussion and conclusion:
Findings highlight the positive impact of strong evidence-provider/user relationships and the importance of governments’ commitment to co-produced research programmes to address policy problems and transparency in the dissemination of methods and findings. From the findings we have created a framework, ‘STEPS’ (Sharing, Transparency, Engagement, Partnership, Strong relationships), of five recommendations for units working with policymakers. These findings will be of value to all researchers conducting research on behalf of government.
#sleepingbaby on Instagram: Nonadherence of images to safe sleeping advice and implications for prevention of Sudden Unexpected Death in Infancy
Authors: Kanits Floortje , L’Hoir Monique P. , Boere-Boonekamp Magda M. , Engelberts Adèle C. , Feskens Edith J. M. 
Published: September 2023

Objectives
Safe sleep of infants is important to reduce the risk of Sudden Unexpected Death in Infancy (SUDI). The depiction of infant care behavior which is inconsistent with the safe sleep recommendations on social media has an impact on parental infant care thoughts, norms and behaviors. This study aims to determine the adherence of Instagram images to the Dutch safe sleeping advice.

Design
A systematic social media analysis on Instagram was performed using 22 hashtags and 9 accounts of Dutch companies or platforms related to infants. Images of sleeping infants were analyzed on consistency with the criteria: supine sleeping position, own cot or crib, sleep sack, and an empty bed.

Results
Based on 514 collected images, 5.9% was consistent with sleep sack use, 16.8% with an empty bed, 30.7% with an own cot or crib, and 67.5% with the supine sleeping position. For 311 images (60.5%), all four criteria could be rated, as for the others, at least one criterion was not clearly depicted. Only 6 of these images (1.9%) were consistent with all four criteria.

Conclusions
Although Instagram images are probably not representative of regular infant care behavior, the exposure to these images that are mostly inconsistent with the safe sleep advice can contribute to the formation of norms, and therefore influence parental care behavior. Accurate communication of the safe sleep recommendations through social media is needed, and opportunities are described for preventive health professionals to engage more in this communication with their public.