bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical Solution Mitigates Stuck Inflow Control Devices in Horizontal Completion
Authors: Sayed Mohammed A. , Chang Frank , Luce Tim 
Published: January 2025

Summary
Horizontal open holes covering long reservoir sections can be benefitted by installing inflow control devices (ICDs) along the lateral to even the production contribution from the entire heterogeneous permeability profile. During the drilling and completion process, the well can be shut in for prolonged periods of time. Though the ICDs are designed to withstand the buildup of debris, they are still subjected to the accumulation of weighting and bridging materials existing in the drilling fluid, such as calcium carbonate (CaCO3). This debris deposits on the internal diameter of the valves or the flow control device, preventing proper shifting against the seats, or blocking the flow path of the devices. Recovering the function of the ICDs requires a chemical treatment. In high-permeability formations, it is undesirable to have acid contact the rock since this may compromise the mechanical integrity of the formation or trigger further solids buildup in the ICDs. Therefore, an acid designed to dissolve the solid deposits on ICDs but not penetrating the formation is required.
In this study, a modified coreflood setup was designed and an acid-based chemical treatment was formulated to remove solid deposition on the ICD. The goal was to dissolve the CaCO3 scale on the ICD with minimal penetration into the formation to avoid formation softening. The core assembly simulates the geometry of the ICD completion system with a core matrix behind the ICD operating space. Calcite marble was used to represent the scale deposited on the ICDs, while Indiana limestone was used to represent the reservoir rock.
Several acid formulations were tested using the custom-designed coreflood setup. One acid blend composed of a strong organic acid [methane sulfonic acid (MSA)] mixed with hydrochloric acid (HCl) and a second blend of HCl and mutual solvent (glycol-based solvent) showed the desirable effect of dissolving the scale deposits (calcite marble in this case) with minimum to no penetration into the formation matrix. The success of the two acid systems in dissolving CaCO3 deposits on the ICDs was confirmed by analyzing the pressure data during the coreflooding experiment, as well as from analyzing the post-treated core samples using computed tomography (CT) scan.
Simulation of completion design in the laboratory is a key factor in testing and designing acid treatments to overcome scale problems in the field. Single-phase acid systems containing no gelling or emulsifying agents were tested and proved capable of dissolving the solids deposited on the ICDs with minimum to no formation contact. This will result in an economical and easier one-step treatment in the field, avoiding the complexity encountered with pulling the whole completion string out of the wellbore to be treated with acid on the surface and then reinstalling it back into the well.
Do children laugh like their parents? Conversational laughter mimicry occurrence and acoustic alignment in middle-childhood
Authors: Mazzocconi Chiara , O’Brien Benjamin , Bodur Kübra , Fourtassi Abdellah 
Published: January 2025

Abstract

Laughter is ubiquitous and crucial in social interactions. In addition to conveying meaning, it is a valuable means for monitoring interlocutor mental states and mutual cognitive alignment. Laughter has been shown to be informative about the pragmatic development of preschool children. The current paper investigates laughter mimicry and acoustic alignment in middle childhood in a corpus of parent-child (N=16) and parent-adult (N=8) computer-mediated conversations. We performed both distributional and acoustic analyses. While there were no significant differences in terms of laughter frequency between children and adults, transitional probabilities of laughter mimicry were significantly lower in parent-child than in parent-adult interactions, although balanced at an intra-dyad level. A spectro-temporal modulation (STM) analysis revealed that in children, Mimicking laughter is characterised by higher STMs than Isolated laughter. On the other hand, in adult, Mimicking and Isolated laughter do not differ in terms of STMs. Further, we compared distances from genuine and pseudo-random Initiating-Mimicking laughter pairs. In adults, laughs constituting genuine pairs were acoustically more similar than those constituting pseudo-random pairs, showing, therefore, local acoustic alignment and confirming previous studies. No such local laughter alignment was found in Children. Our results suggest that although laughter production during middle childhood resembles adult-like use in terms of frequency, speech-laughter use, arousal, and balance between interactants, it is still significantly different when considering laughter mimicry, both in terms of transitional probabilities and acoustic alignment between interlocutors. Our study forms a basis for discussion on current theoretical models of alignment, its interplay with interactional dynamics, and the entanglement of laughter use with pragmatic development.
Social Determinants of Health Informed Interventions to Address or Reduce Sexually Transmitted and Blood Borne Infections Among 2SGBTMSM in High-Income Countries Between 2012 – 2024: A Scoping Review Protocol
Authors: Chin-see Robert Ainsley , Henry Grace , Inglis Fiona , Do Anna , Coleman Todd 
Published: January 2025

Abstract

Background
Two-Spirit, Gay, Bisexual, Transgender, and Men who have Sex with Men (2SGBTMSM) still bear a disproportionate burden of sexually transmitted and blood borne infections (STBBI) such as HIV, despite local and national initiatives aiming to improve screening, testing, and treatment measures. In recent years, interventions aimed at mitigating HIV/STBBI risk and acquisition have leveraged principles of the Social Determinants of Health (SDoH), which encompass social, economic, and political factors known to influence behavior and health outcomes. The primary objective of this scoping review is to evaluate the effectiveness of interventions that are informed by the SDoH framework in preventing or addressing HIV/STBBI among 2SGBTMSM in high-income countries.
Methods
A scoping review of academic and grey literature between 2012 and 2024 will be conducted to identify the landscape of SDoH-informed interventions targeting HIV/STBBI and associated outcomes. The review will adhere to the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) guidelines and guidance from Arksey and O’Malley. The search strategy will be supported by a subject matter librarian and involve the use of relevant search terms (e.g., Chlamydia, 2SGBTMSM, HIV, infection) and Boolean operators across several electronic databases (e.g., MEDLINE, CINAHL, APA PsychInfo). Studies will be selected based on a title and abstract review, followed by a full-text review using inclusion and exclusion criteria determined a priori. Data extracted will include study information, intervention descriptions, and outcomes. Findings will be synthesized narratively and descriptively tabulated. If possible, quality appraisal will be conducted.
Discussion
This review will provide evidence on the current landscape on prevention efforts aimed at 2SGBTMSM regarding HIV/STBBI’s. The utilization of the SDoH in these approaches demonstrate significant promise in the field of public health and equity justice as a low-cost alternative, yet to date, no study has systematically summarized and synthesized the available literature. To fill this gap, the present review will systematically identify and summarize the effectiveness underpinning existing SDoH-informed interventions to address future HIV/STBBI’s prevention efforts for 2SGBTMSM.
Scoping review registration:
This scoping review protocol is registered with Open Science Framework (DOI: https://doi.org/10.17605/OSF.IO/E8D4Z)
Upfront fecal microbiota transplantation for the management of immune checkpoint inhibitor mediated diarrhea and colitis
Authors: Wang Yinghong , Fan Christopher , Varatharajalu Krishnavathana , Shatila Malek , Cruz Carolina , Sun Baohua , Lermi Nejla Ozirmak , Hayase Tomo , Thomas Anusha , Szymonowicz Klaudia , Sanchez-Espiridion Beatriz , Duose Dzifa , Hayase Eiko , Tan Lin , Liu Yiwei , Chang Chia-Chi , Arias Cesar , Junek Kristin , DuPont Herbert , Jiang Zhi-Dong , Kim Sang , Nurieva Roza , Campbell Matthew , Tannir Nizar , Gao Jianjun , Watowich Stephanie , Wang Xin , Chen Ken , Lorenzi Philip , Haymaker Cara , Parra Edwin , Jenq Robert 
Published: January 2025

Abstract

Introduction: Immune checkpoint inhibitors have revolutionized cancer therapy; however, adverse events from an unchecked immune system such as immune checkpoint inhibitor mediated diarrhea and colitis (IMDC) can develop. Fecal microbiota transplantation (FMT) remains an option for patients with refractory colitis, but has not been tested in an upfront setting.
Methods: From an open-label, phase I/II clinical trial (NCT0403861) starting June 2021, we report an analysis of adult patients with IMDC treated with upfront FMT. We performed fecal shotgun metagenomic sequencing, metabolomic, transcriptomic and immunofluorescence profiling pre-FMT and post-FMT and and plasma biomarkers of inflamamtion and immune response pre-FMT to predict response.
Results: 13 patients were treated with FMT, of which 11 (84.6%) achieved clinical response with a median time to clinical improvement of 1(1-5) days. Among responders sequenced with baseline and follow-up (n = 8), 6 patients (75%) had an increase in alpha diversity post-FMT. Notably, in responders Lacrimispora amygdalina and Alistipes shahii increased independently at both 2 and 4 weeks post FMT. Interestingly, aspartic and propionic acid decreased post-FMT (p < 0.05). Using multiplex immunohistochemical immunofluorescence staining of samples obtained at presentation, we determined that total CK+ and CK+Ki67+ cell populations were reduced in non-responder patients. Additionally, there was a trend toward lower pre- and post-FMT CD20+, CD20+Ki67+, CD4+FOXP3+, and CD8+FOXP3+ cell populations in non-responder patients. Immune cell-type abundance scores showed increased plasma cells, neutrophils, (M1 and M2) macrophages, memory activated and resting memory CD4+ T cells , CD8+ T cells,T follicular helper (Tfh) cells, regulatory T cells (Treg), in pre-FMT samples which all decreased dramatically in post-FMT samples, likely related to response to FMT. Non-responders had lower baseline plasma GDF2, TLR3, CCL22, and FGF21 and higher baseline plasma CXCL14, OSM, IL-1β and IFNG.
Conclusion: FMT is a promising front-line therapeutic option for patients who develop IMDC with high efficacy and favorable safety profile. Additional microbiome, blood and tissue analysis provides insights in future directions of potential mechanisms and targets for development of novel therapeutic intervention.
Can physical trauma trigger relapsing polychondritis? The first report from a Chinese cohort and comparison with rheumatoid arthritis and psoriatic arthritis
Authors: Zhang Lei , Yun Shuang , Li Wei , He Yujie , Han Lishuai , Li Ting , Liu Peiling , Liu Xiaojun , Liu Shengyun 
Published: January 2025

Abstract

Objectives
The triggers of relapsing polychondritis (RPC) are not fully characterized. This study was performed to explore the association between physical trauma and RPC.
Methods
The history of physical trauma of 208 patients with RPC from a Chinese cohort was reviewed and compared with that of 1134 patients with rheumatoid arthritis (RA) and 369 patients with psoriatic arthritis (PsA). The characteristics and survival of patients with physical trauma were analyzed.
Results
Eighty patients with RPC (38.5%) ever had physical trauma. This number is considerably higher than that of patients with RA (21.6%, p < 0.0001) and PsA (20.6%, p < 0.0001). A total of 48 patients with RPC (23.1%) had 52 osteochondral injuries, whereas only 58 patients with RA (5.1%, p < 0.0001) and 21 patients with PsA (5.7%, p < 0.0001) ever had osteochondral injuries. We found that more patients with RPC experienced any type of physical trauma, as well as osteochondral trauma, in the preceding one year , and also half a year, before disease onset than patients with RA and PsA. Traumatic events (osteochondral and nonosteochondral) increased in the preceding one year before disease onset, especially in the preceding six months. Patients with osteochondral trauma that occurred at any time before disease onset had a higher rate of airway involvement and lower rates of survival than those without osteochondral trauma.
Conclusion
Our findings suggest that physical trauma may be triggers of RPC, and that patients with osteochondral trauma seem to have more severe disease than those without.
Infants display reduced NK cell responses in RSV and increased inflammatory responses in SARS-CoV-2 infections
Authors: Ucar Duygu , Thibodeau Asa , Mejias Asuncion , Nehar-Belaid Djamel , Marches Radu , Xu Zhaohui , Eryilmaz Giray , Josefowicz Steven , Paust Silke , Pascual Virginia , Banchereau Jacques , Ramilo Octavio 
Published: January 2025

Abstract

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection hospitalizations in infants and poses a significantly higher risk of respiratory failure than SARS-CoV-2. The mechanisms underlying these differences remain unclear. We analyzed blood samples from infants (median age 2.3 months) with SARS-CoV-2 (n = 30), RSV (n = 19), and healthy controls (n = 17) using single-cell transcriptomics and epigenomics, and cytokine profiling. Both viruses triggered comparable interferon responses across PBMC subsets but differed in NK cell and inflammatory responses. Severe RSV cases showed reduced NK cell frequencies, lower IFNG expression, and decreased chromatin accessibility at T-BET and EOMES binding sites. RSV infections were also associated with increased CD4+ TEMRA, memory Treg and transitional B cells. In contrast, SARS-CoV-2 was characterized by stronger pro-inflammatory signatures, including increased NFKB pathway activity and higher serum TNF concentrations. These findings highlight distinct immune responses to RSV and SARS-CoV-2, providing insights that may inform clinical decisions.
In-situ Synthesis of g-C 3 N 4 with Nitrogen Vacancy and Cyano Group via One-pot Method for Enhanced Photocatalytic Activity
Authors: BI Xiang , WANG Li-Zhong , ZHAI Dong-Hua , WANG Lei , YANG Hui , DU Gao-Hui 
Published: January 2025

Abstract

In-situ synthesis of g-C3N4 containing nitrogen vacancies and cyano group via one-pot method using urea as the precursor. The structural, morphological or electrochemical properties of synthesized photocatalysts were characterized by XRD, BET analysis, TEM, FTIR, UV-DRS, PL, XPS and EPR. It was found that the nitrogen vacancy was successfully introduced into g-C3N4. Compared to pure g-C3N4, the (200) crystal plane in XRD of synthesized g-C3N4 showed slight red-shift, and the BET surface areas had changed from 27.5 to 35.7 m2·g− 1, which could provide more reaction center and active site. TEM confirmed that g-C3N4 and VN-g-C3N4 were porous materials, and FTIR, XPS as well as EPR could prove the presence of nitrogen vacancies and cyano group. The UV-Vis absorption edge of VN-g-C3N4 demonstrated briefly red-shift, PL intensity and lifetime of carriers declined in comparison with pure g-C3N4. Electrochemical test results showed that enhanced charge separation efficiency and low recombination rate of charge carriers of VN-g-C3N4. The photocatalytic activity of the photocatalysts was researched by RhB degradation and ACT removal under visible light irradiation, the results showed the rate of RhB degradation on the VN-g-C3N4 was 81%, which was 1.4-fold as high as that of g-C3N4 in visible light. The degradation contribution from the active species were h+ (67.3%) >1O2(63.0%)>•OH (49.4%) >•O2− (20.3%) > e− (20.1%) > H2O2(0.2%), and VN-g-C3N4 exhibited excellent ACT removal rate,which was 1.6-fold higher than that of pure g-C3N4 in visible light. This study provides an efficient photocatalyst for the treatment of toxic wastewater.
Mechanism of Jiangan Jiangzhi Pill NRF2 pathway in the treatment of steatohepatitis in mice
Authors: Jiao Xue , Wang Li , Li Yinglun , Liu Jing , Wei Qian , Mi Yuqiang , Li Ping 
Published: January 2025

Abstract

Objective observe the healthy liver cholesterol-lowering pills for methionine choline lack of feed (Methionine-choline deficient，MCD) diet induced nonalcoholic fatty hepatitis (Nonalcoholic steatohepatitis，NASH) mechanism of lipid metabolism and inflammation in mice.
Methods The mice were randomly divided into control group, model group, positive drug group, low, medium and high dose groups of Jianganjiangzhi pills, 10 mice in each group.The control group ate normal diet, and the other experimental groups ate MCD diet.The positive drug group was intritoneally injected with 150mg/kg polyene phosphatidylcholine, the low, medium and high dose groups of Jiangan Jiangzhi pills were administrated with 100 mg/kg, 200 mg/kg and 400 mg/kg respectively, once a day, and the control group and model group were given equal volume of normal saline in parallel.Weigh and record every 7 days.It lasts six weeks.The histopathological changes of liver were observed by HE staining.Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected by biochemical kit,The levels of total cholesterol (TC), triglyceride (TG), superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) in liver homogenate were detected by BCA kit.The mRNA expression levels ofNrf2, Ho1, Gclc and Nqo1 in mouse liver tissues were detected by PCR,The expression level ofNRF2 pathway related protein in mouse liver was detected by Western blot .
Results Compared with the normal group, the model group had serious liver pathological injury, severe destruction of liver cell structure, widening of cell interval, collapse and infiltration of a large number of inflammatory cells.In the model group, ALT, AST, TG and TC (P<0.01) levels were significantly increased, SOD activity was decreased, MDA level was increased, and GSH-Px activity was decreased. PCR results showed that mRNA expression levels ofNrf2, Ho1, Gclc and
Nqo1 in mouse liver tissues were decreased.Westernblot results showed that the relative expression levels ofNRF2, HO-1,GCLC and NQO1 proteins in mice were significantly decreased. Compared with the model group, the liver cell structure of mice in positive drug group (polyene phosphatidylcholine) and Jianggan Jiangzhiwan low-dose, medium-dose and high-dose groups was more clear, with a shorter cell interval and a small amount of inflammatory cell infiltration,ALT, AST,TG and TC levels decreased significantly, SOD activity increased, MDA level decreased, GSH-Px activity increased. The mRNA expression levels ofNrf2, Ho1, Gclc and Nqo1 in liver tissues were increased, and the protein expression levels of NRF2 pathway related proteins were significantly increased.
Conclusion Jiangan Jiangzhi pills(健肝降脂丸) can regulate NRF2 pathway to enhance antioxidant capacity and reduce liver steatosis and inflammation in mice with NASH
Research trends in vascular aging in the last decade: a comprehensive bibliometric analysis
Authors: Shi Dandan , Ning Ziqi , Zhang Yaoyao , Guo Xiaochen , Liu Meixia , Wei Yun 
Published: January 2025

Abstract

Background
In recent years, vascular aging has become an important direction of aging research, but a comprehensive bibliometric analysis has not been conducted.
Methods
The Web of Science database was searched for articles and reviews on vascular aging from January 1, 2014, to August 20, 2024, and the literature was analyzed and knowledge maps were constructed using CiteSpace, VOSviewer, pajek and Scimago Graphica software for econometric analysis and knowledge graph construction of the literature.
Result
A total of 38,910 authors from 7,622 institutions in 111 countries published 7,277 papers in 1,344 academic journals, with a significant increase in publication volume. The United States is the country with the highest productivity and citation rates, and Mayo Clinic is the most active institution. Tarantini S published the most papers, while Csiszar A received the most citations. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES journal published the most papers, and CIRCULATION journal received the most citations. The main research aspects include age-related macular degeneration, arteriosclerosis, and oxidative stress, which are the main keywords in this field. In the last decade, the term c reactive protein has attracted great attention with its strongest citation explosion.
Conclusion
In the past decade, the research focus on vascular aging has been increasing year by year. Age-related macular degeneration, arteriosclerosis, and oxidative stress are the emerging research directions in this field. Vascular endothelial cells will be the focus of future research in this field.
Numerical studies on thermo-hydraulic performance of solar air heater with quarter circle roughness ribs
Authors: Bizuneh Yaregal Eneyew , Kassie Tazebew Dires , Bizuneh Atalay Enyew 
Published: January 2025

Abstract

With their diverse range of applications, solar air heaters transform renewable solar energy into useful heat. The fluid flow and heat transfer properties of a roughened solar air heater with quarter-circle-shaped ribs were examined in-depth using numerical analysis. The k–e RNG turbulence model was used to conduct 2D steady-state numerical simulations, and the findings showed excellent agreement with the smooth duct and related literatures. The impact of rib spacing was explored by changing the rib relative pitch (p/e) from 6.67 to 13.3 for Reynolds numbers (Re) between 4,000 and 20,000. The thermo-hydraulic performance factor was found to be 1.63. Additionally, it was shown that an increase in relative pitch (p/e) of 6.67 to 10 resulted in an increase in the Nusselt number for all Re values examined. At Re of 16,000, an enhancement of 2.42 times the Nu was made for p/e = 6.67. It was also noted that for all Re values taken into consideration, Nu falls with an increase in p/e from 10 to 13.3.