bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localization of macrophages and dendritic cells in human thoracic lymph nodes: An immunohistochemical study using surgically obtained specimens
Authors: Aoki Masaya , Jin Zhe‐Wu , Ueda Kazuhiro , Kamimura Go , Takeda‐Harada Aya , Murakami Gen , Sato Masami 
Published: April 2023

AbstractBoth dendritic cells (DCs) and macrophages are bone marrow‐derived cells that perform antigen presentation. The distribution of DCs and CD68‐positive macrophages were immunohistochemically examined in 103 thoracic nodes obtained from 23 lung cancer patients (50–84 years old) without metastasis. Among three antibodies tested initially—CD209/DCsign, fascin, and CD83—DCsign was chosen as the DC marker. For comparison, 137 nodes from 12 patients with cancer metastasis were also examined histologically. In patients without metastasis, DCs were found as (1) clusters along the subcapsular sinus and in a border area between the medullary sinus and cortex (mean sectional area of multiple nodes at one site, 8.4%) and, (2) rosette‐like structures in the cortex (mean number in multiple nodes at one site, 20.5). Notably, DC clusters and rosettes contained no or few macrophages and were surrounded by smooth muscle actin (SMA)‐positive, endothelium‐like cells. The subcapsular linear cluster corresponded to 5%–85% (mean, 34.0%) of the nodal circumferential length and was shorter in older patients (p = 0.009). DC rosettes, solitary, or communicating with a cluster, were usually connected to a paracortical lymph sinus. Few differences were found between nodes with or without metastasis, but DC cluster sometimes contained abundant macrophages in cancer metastasis patients. The subcapsular DC cluster is not known in the rodent model, in which the subcapsular sinus is filled with macrophages. This quite different, even complementary, distribution suggests no, or less, cooperation between DCs and macrophages in humans.
Cultural considerations at end‐of‐life for people of culturally and linguistically diverse backgrounds: A critical interpretative synthesis
Authors: Lambert Elizabeth , Strickland Karen , Gibson Jo 
Published: April 2023

AbstractPurpose/AimTo establish cultural considerations for people from culturally or linguistically diverse backgrounds at the end‐of‐life in Australia.BackgroundGlobally, there is a rapidly increasing proportion of the ageing population, and high levels of migration to Australia, the Australian healthcare community must recognise individualised and cultural needs when approaching death and end‐of‐life care. Many people from culturally and linguistically diverse backgrounds do not traditionally practice the palliative care approaches that have been developed and practised in Australia.DesignA Critical Interpretive Synthesis.MethodsA review protocol was established using PRISMA 2020 guidelines and the literature searched using CINAHL, PubMed, Psych INFO and Medline from January 2011 to 27th February 2021. This search protocol results in 19 peer‐reviewed results for inclusion in critical analysis.ResultsIncluded studies were qualitative (14), quantitative (4) and mixed methods (1). Four themes were identified from the literature: (i) communication and health literacy; (ii) access to end‐of‐life care services; (iii) cultural norms, traditions and rituals; and (iv) cultural competence of healthcare workers.ConclusionsHealthcare workers have an essential role in providing care to people with life‐limiting illnesses. Cultural considerations during end‐of‐life care are imperative for the advancement of nursing practice. To achieve effective care for people of culturally and linguistically diverse backgrounds during end‐of‐life care, healthcare workers need to increase their education and cultural competency. There is inadequate research conducted within specific cultural groups, rural and remote Australian communities and individual cultural competence of healthcare workers.Implications for PracticeContinuing advancement within nursing practice relies on health professionals adopting a person‐centred and culturally appropriate approach to care. To ensure individualised person‐centred care is provided in a culturally appropriate way, healthcare workers must learn to reflect on their practice and actively advocate for people with culturally and linguistically diverse backgrounds during end‐of‐life care.
How modern working environments shape attendance behaviour: A longitudinal study on weekly flexibilization, boundaryless work and presenteeism
Authors: Poethke Ute , Klasmeier Kai N. , Radaca Elvira , Diestel Stefan 
Published: April 2023

AbstractIn the face of technological advancements, flexibilization and boundaryless work have become integral parts of modern occupational settings. Simultaneously, current research indicates a considerable increase in presenteeism—the behaviour of working while sick. Meta‐analytic findings indicate two main drivers for presenteeism: a high work motivation and an impaired state of health and psychological well‐being. Research on flexibilization and boundaryless work shows that these job conditions enhance employees' work motivation but also impair employees' health. Based on conservation of resources theory and Miraglia and John's (J Occupational Health Psychol, 21, 2016, 261) dual‐path model on antecedents of presenteeism, we investigate how both job conditions affect attendance behaviour (absenteeism and presenteeism) via motivation and well‐being by conducting a weekly diary study over the course of 9 weeks. In total, 284 people provided data on flexibilization, boundaryless work, flow experience, well‐being, absenteeism and presenteeism (N = 2284 week‐level). Multilevel mediational analyses revealed that flexibilization prevents presenteeism, whereas boundaryless work can increase presenteeism. The results further revealed support for the health impairment path at the within‐person and between‐person levels whereas the motivational path was not supported at the within‐person level. Our results offer several theoretical and practical implications for how modern work shape attendance behaviour.
Culture and the way of granting job autonomy: Goal or execution?
Authors: Jiang Feng , Lu Su , Ji Li‐Jun , Wang Hai‐Jiang 
Published: April 2023

AbstractResearchers have assumed that Westerners exercise higher job autonomy than Easterners. However, recent studies have reported mixed and even contradictory findings. The authors distinguish between two types of job autonomy, namely goal and execution autonomy, to examine the relevant cultural differences. The former denotes participation in setting work goals and making plans for meeting those goals, while the latter denotes the ability to complete tasks flexibly. Four studies with a total sample of 1192 participants working in financial or insurance companies were conducted. Study 1a generated items for a new measure of the two types of job autonomy and explored its factor structure. Studies 1b and 1c verified its construct validity and predictive capacity. Study 2 confirmed the structural and metric equivalence of the measure between samples from the United Kingdom and China. The results of Study 2 suggested that the Chinese workers were likely to have high execution autonomy but low goal autonomy, whereas the British workers tended to have high goal autonomy but low execution autonomy. The theoretical and practical implications of job autonomy in cross‐cultural contexts are discussed.
Cyanoseq: A database of cyanobacterial 16S rRNA gene sequences with curated taxonomy
Authors: Lefler Forrest W. , Berthold David E. , Laughinghouse H. Dail 
Published: April 2023

AbstractCyanobacteria are photosynthetic bacteria that occupy various habitats across the globe, playing critical roles in many of Earth's biogeochemical cycles both in both aquatic and terrestrial systems. Despite their well‐known significance, their taxonomy remains problematic and is the subject of much research. Taxonomic issues of Cyanobacteria have consequently led to inaccurate curation within known reference databases, ultimately leading to problematic taxonomic assignment during diversity studies. Recent advances in sequencing technologies have increased our ability to characterize and understand microbial communities, leading to the generation of thousands of sequences that require taxonomic assignment. We herein propose CyanoSeq (https://zenodo.org/record/7569105), a database of cyanobacterial 16S rRNA gene sequences with curated taxonomy. The taxonomy of CyanoSeq is based on the current state of cyanobacterial taxonomy, with ranks from the domain to genus level. Files are provided for use with common naive Bayes taxonomic classifiers, such as those included in DADA2 or the QIIME2 platform. Additionally, FASTA files are provided for creation of de novo phylogenetic trees with (near) full‐length 16S rRNA gene sequences to determine the phylogenetic relationship of cyanobacterial strains and/or ASV/OTUs. The database currently consists of 5410 cyanobacterial 16S rRNA gene sequences along with 123 Chloroplast, Bacterial, and Vampirovibrionia (formally Melainabacteria) sequences.
BcTaf14 regulates growth and development, virulence, and stress responses in the phytopathogenic fungus Botrytis cinerea
Authors: Han Hongjia , Lv Fangjiao , Liu Zhishan , Chen Tongge , Xue Tianzi , Liang Wenxing , Liu Mengjie 
Published: April 2023

AbstractTATA box‐binding protein (TBP)‐associated factor 14 (Taf14), a transcription‐associated factor containing a conserved YEATS domain and an extra‐terminal (ET) domain, is a multifunctional protein in Saccharomyces cerevisiae. However, the role of Taf14 in filamentous phytopathogenic fungi is not well understood. In this study, the homologue of ScTaf14 in Botrytis cinerea (named BcTaf14), a destructive phytopathogen causing grey mould, was investigated. The BcTaf14 deletion strain (ΔBcTaf14) showed pleiotropic defects, including slow growth, abnormal colony morphology, reduced conidiation, abnormal conidial morphology, reduced virulence, and altered responses to various stresses. The ΔBcTaf14 strain also exhibited differential expression of numerous genes compared to the wild‐type strain. BcTaf14 could interact with the crotonylated H3K9 peptide, and mutation of two key sites (G80 and W81) in the YEATS domain disrupted this interaction. The mutation of G80 and W81 affected the regulatory effect of BcTaf14 on mycelial growth and virulence but did not affect the production and morphology of conidia. The absence of the ET domain at the C‐terminus rendered BcTaf14 unable to localize to the nucleus, and the defects of ΔBcTaf14 were not recovered to wild‐type levels when BcTaf14 without the ET domain was expressed. Our results provide insight into the regulatory roles of BcTaf14 and its two conserved domains in B. cinerea and will be helpful for understanding the function of the Taf14 protein in plant‐pathogenic fungi.
Effect of peripheral defocus on axial growth and modulation of refractive error in children with anisohyperopia
Authors: Beasley Ian G. , Davies Leon N. , Logan Nicola S. 
Published: April 2023

AbstractPurposeTo establish whether axial growth and refractive error can be modulated in anisohyperopic children by imposing relative peripheral hyperopic defocus (RPHD) using multifocal soft contact lenses.MethodsThis study is a prospective, controlled paired‐eye study with anisohyperopic children. Axial growth and refractive error were observed without intervention for the first 6 months of the 3‐year trial with participants wearing single vision spectacles. Then, participants wore a centre‐near, multifocal, soft contact lens (+2.00 D add) in their more hyperopic eye for 2 years, with a single vision contact lens worn in the fellow eye if required. The ‘centre‐near’ portion of the contact lens in the more hyperopic eye corrected distance refractive error while the ‘distance’ portion imposed hyperopic defocus in the peripheral retina. Participants reverted to single vision spectacles for the final 6 months.ResultsEleven participants, mean age of 10.56 years (SD 1.43; range 8.25–13.42), completed the trial. No increase in axial length (AL) was found during the first 6 months in either eye (p > 0.99). Axial growth across the 2‐year intervention period was 0.11 mm (SEM 0.03; p = 0.06) in the test eye versus 0.15 mm (SEM 0.03; p = 0.003) in the control eye. AL was invariant during the final 6 months in both eyes (p > 0.99). Refractive error was stable during the first 6 months in both eyes (p = 0.71). Refractive error change across the 2‐year intervention period was −0.23 D (SEM 0.14; p = 0.32) in the test eye versus −0.30 D (SEM 0.14; p = 0.61) in the control eye. Neither eye demonstrated a change in refractive error during the final 6 months (p > 0.99).ConclusionsImposing RPHD using the centre‐near, multifocal, contact lens specified here did not accelerate axial growth nor reduce refractive error in anisohyperopic children.
Early‐life environment and the risk of eczema at 2 years—Meta‐analyses of six Finnish birth cohorts
Authors: Lukkarinen Minna , Kirjavainen Pirkka V. , Backman Katri , Gonzales‐Inca Carlos , Hickman Brandon , Kallio Sampo , Karlsson Hasse , Karlsson Linnea , Keski‐Nisula Leea , Korhonen Laura S. , Korpela Katri , Kuitunen Mikael , Kukkonen Anna Kaarina , Käyhkö Niina , Lagström Hanna , Lukkarinen Heikki , Peltola Ville , Pentti Jaana , Salonen Anne , Savilahti Erkki , Tuoresmäki Pauli , Täubel Martin , Vahtera Jussi , de Vos Willem M. , Pekkanen Juha , Karvonen Anne M. 
Published: April 2023

AbstractBackgroundUrban‐related nature exposures are suggested to contribute to the rising prevalence of allergic diseases despite little supporting evidence. Our aim was to evaluate the impact of 12 land cover classes and two greenness indices around homes at birth on the development of doctor‐diagnosed eczema by the age of 2 years, and the influence of birth season.MethodsData from 5085 children were obtained from six Finnish birth cohorts. Exposures were provided by the Coordination of Information on the Environment in three predefined grid sizes. Adjusted logistic regression was run in each cohort, and pooled effects across cohorts were estimated using fixed or random effect meta‐analyses.ResultsIn meta‐analyses, neither greenness indices (NDVI or VCDI, 250 m × 250 m grid size) nor residential or industrial/commercial areas were associated with eczema by age of 2 years. Coniferous forest (adjusted odds ratio 1.19; 95% confidence interval 1.01–1.39 for the middle and 1.16; 0.98–1.28 for the highest vs. lowest tertile) and mixed forest (1.21; 1.02–1.42 middle vs. lowest tertile) were associated with elevated eczema risk. Higher coverage with agricultural areas tended to associate with elevated eczema risk (1.20; 0.98–1.48 vs. none). In contrast, transport infrastructure was inversely associated with eczema (0.77; 0.65–0.91 highest vs. lowest tertile).ConclusionGreenness around the home during early childhood does not seem to protect from eczema. In contrast, nearby coniferous and mixed forests may increase eczema risk, as well as being born in spring close to forest or high‐green areas.
On Rooting Religious Studies: The Metaphysical Proposal of René Guénon
Authors: Taj Noah H. 
Published: April 2023

AbstractThe present article problematizes current dominating approaches to method and theory in the study of religion by pointing to their inapplicability to theorists working outside secular worldviews. The first section of this article introduces decolonialist narratives by touching on important topics which are subsumed within larger discussions, such as secularism, positionality, and others. This is done by putting René Guénon (1886–1951) in conversation with other theorists, the foremost of whom is Bruce Lincoln. Section two introduces Guénon using Wael Hallaq's categorisation of him as a subversive author, and sections three and four elaborate on his subversion through touching on two key theories. The first relates to problematizations of the term ‘religion’ itself along with a treatment of Guénon's actual theory of religion. The second is Guénon'smetaphysicalmethod, which, contrasted against the historical, opens new avenues for our study of the past in manners unrestricted to materialism alone, expanding thereby the academic frameworks with which we come to the table in the academic study of religion.
An alternative interpretation for tailing in survival curves for bacteria exposed to germicidal radiation
Authors: Oppezzo Oscar J. , Abrevaya Ximena C. , Giacobone Ana F. F. 
Published: April 2023

AbstractIt has been proposed that transient and reversible phenotypic changes could modify the response of bacteria to germicidal radiation, eventually leading to tailing in the survival curves. If this were the case, changes in susceptibility to radiation would reflect variations in gene expression and should only occur in cells in which gene expression is active. To obtain experimental evidence supporting the involvement of phenotypic changes in the origin of tailing, we studied changes in the susceptibility to radiation of cells able to survive high fluences, using split irradiations. Stationary phase cells of Enterobacter cloacae and Deinococcus radiodurans, in which gene expression is active, and spores of Bacillus subtilis, which are dormant cells without active gene expression, were used as microbial models. While cells of E. cloacae and D. radiodurans became susceptible after surviving exposures to high fluences, tolerant spores exhibited unchanged response to radiation. The results can be interpreted assuming that noise in gene expression modifies bacterial susceptibility to radiation, and tailing is the result of intrinsic phenomena of bacterial physiology rather than a technical artifact. For either theoretical or practical purposes, deviations from simple exponential decay kinetics should be considered in estimations of the effects of germicidal radiation at high fluences.
Creating the executive budget process: What was Congress thinking?
Authors: Douglas James W. , Kravchuk Robert S. 
Published: April 2023

AbstractThe recent centennial of the 1921 Budget and Accounting Act presents an opportunity to reconsider the importance of the federal executive budget to American political development. Of particular interest is the apparent shift in political authority from Congress to the president that is sometimes attributed to the Act. The 1921 Act generally marks the rise of the modern presidency, where the president received a durable grant of authority. We examine the congressional hearings and debates regarding the budget process from 1919 to 1921 to assess Congress's expectations of the new budget system it was creating. We show that Congress expected to benefit from the executive budget process and did not view it as a threat to its budget authority. Congress recognized that the executive branch had influence in the budget process, but it preferred presidential influence to department heads’ influence. The 1921 Act, at least initially, enhanced the budgeting capacities ofboththe president and Congress in mutually beneficial ways.
Vascular characterization and morphogenesis in porcine placenta at day 40 of gestation
Authors: Fiorimanti M. R. , Cristofolini A. L. , Rabaglino M. B. , Moreira‐Espinoza M. J. , Grosso M. C. , Barbeito C. G. , Merkis C. I. 
Published: April 2023

AbstractIn porcine placenta, abnormal development of the placental vasculature leads to placental insufficiency. The aim of this study was to determine the mRNA expression of angiogenic growth factors and to determine the vascular characteristics in placenta at day 40 of pig gestation. Samples were collected from maternal‐chorioallantoic interface (n = 21) for the measurement of mRNA expression of VEGFA, ANGPT1, ANGPT2, FGF2 and its receptors KDR, TEK, FGFR1IIIc, FGFR2IIIb respectively, and for immunohistochemistry analysis of CD31 and VEGFA. Immunohistochemical analysis of CD31 and VEGFA, morphometric measurement of blood vessels, high‐resolution light microscopy and transmission electron microscopy were performed. Capillary area density, number of blood vessels and capillary area were significantly higher on the maternal side than on the fetal side (p < .05). The ultrastructural finding of blood vessels demonstrates close contact with the trophoblastic epithelium. The relative mRNA expression of VEGFA and its receptor KDR was higher compared with the other angiogenic genes. In conclusion, a high mRNA expression of VEGFA and its receptor KDR added to the immunohistochemical results suggest a potential role of these genes in this pathway associated with an increase in the density of the capillary area on the maternal side and a reduction in the hemotrophic diffusion distance at the interface for nutrient exchange.
Hemodialysis vascular access coordinator: Three‐level model for access management
Authors: Sousa Clemente Neves , Teles Paulo , Sousa Rui , Cabrita Filipa , Ribeiro Olga Maria Pimenta Lopes , Delgado Elisabete , Coutinho Sara , Moura Sandra Cristina Mendo , Delgado Millena Freire , Costa João Filipe , Sá Tiago Gomes , Teixeira Sílvia Mónica Pereira , Mendonça Ana Elza Oliveira , Ozen Nurten 
Published: April 2023

AbstractManagement of vascular access is a challenge for the dialysis team, particularly to keep the arteriovenous access working. The vascular access coordinator can positively contribute to increase the number of arteriovenous fistulas and reduce central venous catheters. In this article, we introduce a new approach to vascular access management centered on (the results of setting up) the role of vascular access coordinator. We described the three‐level model (3Level_M) for vascular access management organized in three levels: vascular access nurse manager, vascular access coordinator, and vascular access consultant. We defined the instrumental skills and training required to be developed by each element and clarify the articulation between the model and all members of the dialysis team related to vascular access.
A new reef classification model with insights into Phanerozoic evolution of reef ecosystems
Authors: Yao Le , Kershaw Stephen , Shen Shuzhong , Wang Xiangdong 
Published: April 2023

AbstractOrganic reefs are largely calcareous build‐ups of sessile organisms, commonly in shallow marine ecosystems, with a long Precambrian to Modern history. Despite a long history of study, the reef classification is still open to development due to reefs encompassing diverse organic and inorganic components with various imprecise and synonymous terms. In this study, a new classification model for organic reefs is expressed in two hierarchical levels.Level 1: Reef outline geometry has two major forms: bioherms (prominent relief and laterally constrained) and biostromes (low relief and large lateral extension interbedded with non‐reef sediments), within which constructional components highly vary.Level 2: Four reef constructor groups form end‐members in a pyramid diagram: macroskeleton (S), microbia (Mi), matrix (Ma) and cement (C). Thus five reef types are recognized depending on the composition and structure of these constructors: (i) S‐supported reef; (ii) Mi‐supported reef (calcimicrobial and agglutinated microbial); (iii) Ma‐supported reef (cluster and carbonate mud mound); (iv) C‐supported reef; and (v) hybrid component‐supported reef (comprising two or more major types of reef components). This arrangement makes a more streamlined and accessible reef classification than prior schemes. Two associated non‐reef habitats that may grade into reefs are relevant: debris biostromes/banks and level‐bottom communities containing taxa found in adjacent reefs. Based on this ‘SMiMaC’ model, the structural evolution of reef ecosystems is demonstrated for the Phanerozoic, characterized by S‐supported and hybrid‐supported, and Mi‐supported and Ma‐supported structures under cooling and intense warming climates, respectively.