bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissociating Attentional Capture from Action Cancellation in the Stop Signal Task
Authors: Weber Simon , Salomoni Sauro , Kilpatrick Callum , Hinder Mark R. 
Published: December 2022

ABSTRACTInhibiting ongoing responses when environmental demands change is a critical component of human motor control. Experimentally, the stop signal task (SST) represents the gold standard response inhibition paradigm. However, an emerging body of evidence suggests that the SST conflates two dissociable sources of inhibition, namely an involuntarily pause associated with attentional capture and the (subsequent) voluntary cancellation of action. The extent to which these processes also occur in other response tasks is unknown.24 younger (20-35 years) and 23 older (60-85 years) adults completed a series of tasks involving rapid unimanual or bimanual responses to a visual stimulus. A subset of trials required cancellation of one component of an initial bimanual response (i.e., selective stop task; stop left response, continue with right response) or enacting an additional response (e.g., press left button as well as right button). Critically, both tasks involved some infrequent stimuli which bore no behavioural imperative (i.e., they had to be ignored).EMG recordings of voluntary responses during the stopping tasks revealed bimanual covert responses (i.e., muscle activation which was suppressed before a button press ensued), consistent with a pause process, following both stopandignore stimuli, before the required response was subsequently enacted. Critically, we also observed the behavioural consequences of a similar involuntary pause in trials where action cancellation was not part of the response set (i.e., when the additional stimulus required additional action or ignoring, but not inhibition). The findings shed new light on the mechanisms of inhibition and their generalisability to other task contexts.
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response
Authors: Ikeda Ryo , Noshiro Daisuke , Morishita Hideaki , Takada Shuhei , Kageyama Shun , Fujioka Yuko , Funakoshi Tomoko , Komatsu-Hirota Satoko , Arai Ritsuko , Ryzhii Elena , Abe Manabu , Koga Tomoaki , Nakao Mitsuyoshi , Sakimura Kenji , Horii Arata , Waguri Satoshi , Ichimura Yoshinobu , Noda Nobuo N , Komatsu Masaaki 
Published: December 2022

AbstractNRF2 is a transcription factor responsible for antioxidant stress responses that is usually regulated in a redox-dependent manner. p62 bodies formed by liquid-liquid phase separation contain Ser349-phosphorylated p62, which participates in the redox-independent activation of NRF2. However, the regulatory mechanism and physiological significance of phosphorylation remain unclear. Herein, we identify ULK1 as a kinase responsible for phosphorylation of p62. ULK1 co-localizes with p62 bodies, and directly interacts with p62. This phosphorylation allows KEAP1 to be retained within p62 bodies, activating NRF2.p62S351E/+mice are phosphomimetic knock-in mice in which Ser351 corresponding to human Ser349 is replaced by Glu. These mice, but not phosphodefectivep62S351A/S351Amice, exhibit NRF2 hyperactivation and growth retardation, the latter caused by malnutrition and dehydration due to obstruction of the esophagus and forestomach secondary to hyperkeratosis.p62S351E/+mice are a phenocopy of systemicKeap1-knockout mice. Our results expand our understanding of the physiological importance of the redox-independent NRF2 activation pathway and provide new insight into the role of phase separation in this process.
Three-dimensional natural frequency investigation of bidirectional FG truncated thick hollow cone
Authors: Najibi Amir , Kianifar Morteza , Ghazifard Payman 
Published: December 2022

PurposeThe authors examined the numerical natural frequency analysis of a 2D functionally graded (FG) truncated thick hollow cone using 3D elasticity theory.Design/methodology/approachThe material properties of the 2D-FGM (two dimensional-functionally graded materials) cone are graded along the radial and axial axes of the cone using a power–law distribution. The eigenvalue problem was solved using finite element analysis (FEA) employing graded hexahedral elements, and the verification of the finite element approach was assessed by comparing the current solution to earlier experimental studies.FindingsThe effects of semivertex angle, material distribution and the cone configuration on the natural frequencies have been analyzed. For various semivertex angles, thickness, length and power law exponents, many results in the form of natural frequencies and mode shapes are presented for the 2D-FGM cone. As a result, the effects of the given parameters were addressed, and the results were compared, demonstrating the direct efficiency of raising the power–law exponents and cone thickness on the rise of natural frequencies.Originality/valueFor the first time, the numerical natural frequency analysis of a 2D-FG truncated thick hollow truncated cone based on 3D equations of elasticity has been investigated. The material properties of the truncated cone have been distributed along two directions, which has not been considered before in any research for the truncated thick cone. The reason for using these innovative volume fraction functions is the lack of accurate coverage by functions that are available in the literature (Asemi et al., 2011; Babaei et al. 2021).
Influencing sub-contracted operatives' attitudes and behaviours towards improved health and safety culture in construction
Authors: Ajayi Saheed O. , Lister Natasha , Dauda Jamiu Adetayo , Oyegoke Adekunle , Alaka Hafiz 
Published: December 2022

PurposeHealth and safety is an important issue in workplaces, and despite safety procedures becoming more strict, serious accidents are still happening within the UK construction sector. This demonstrates poor performance in the implementation of safety procedures on construction sites. One of the key challenges is the unwillingness of the site workforce, especially the subcontracted operatives, to adhere to safety provisions on construction sites. As such, this study investigates the strategies for enhancing safe behaviour amongst subcontracted operatives in the UK construction industry.Design/methodology/approachThe study used exploratory sequential mixed method research, involving interviews and questionnaires as means of data collection, and thematic analysis, reliability analysis and exploratory factor analysis as methods of data analysis.FindingsThe study suggests that various carrot and stick measures are expected to be put in place as part of the strategies for enhancing safe behaviour amongst subcontracted operatives. These include adequate enforcement of safety practices by the management, operative engagement and motivation, commendation and rewards, site safety targets, leadership style and motivation.Originality/valueApplication of the suggested measures could enhance safety on construction sites, as it provides practical measures and solutions for inculcating safety behaviours amongst the site operatives who are most likely to be the victims of site accidents.
Strategic responses to the pandemic: a case study of the US department store industry
Authors: Wang Ruifeng , Dresner Martin , Pan Xiaodan 
Published: December 2022

PurposeThe study focuses on (1) the success of three strategies employed during the pandemic – two “persevering” strategies, curbside pickup and return window extension and one innovative strategy, virtual try-on technology and (2) whether the strategies are likely to be successful in the post-pandemic world.Design/methodology/approachThe authors utilize a panel dataset containing 17 department store chains in the US The panel includes weekly sales by the retailers at the city level from 2018 to 2021, encompassing both a pre-COVID-19 period and a period during the pandemic. A two-way fixed effects model, including retailer-city fixed effects and year-week fixed effects, is used to estimate department store sales.FindingsThe authors find that the two persevering strategies offset the negative impact of government-imposed containment and health measures on sales performance. On the other hand, the innovative strategy is more effective with a low level of containment and health measures, leading to our observation that virtual try-on may be more sustainable than the other two strategies in a post-pandemic environment.Originality/valueThis paper makes the following contributions: First, the authors contribute to the literature on strategies that may be used to respond to crises. Second, the authors contribute to the retail management literature, assessing the impact of the three retail strategies on department store sales. Finally, the authors compare the impact on sales of the two persevering strategies to the innovative strategy and conclude that a mix of these types of strategies may be most effective at generating short-term sales during a crisis and longer-term sales post crisis.
Examining how and when digital platform capabilities drive technological innovation: a strategic information perspective
Authors: Liu Longjun , Long Jing , Liu Ruhong , Fan Qing , Wan Wenhai 
Published: December 2022

PurposeThis study aims to examine how and when digital platform capabilities drive technological innovation from a strategic information perspective, regarding information flow and information quality as mediators and business intelligence analytics as a moderator.Design/methodology/approachThis study engaged corporate executives in surveys and obtained 182 firm data and then tested the hypotheses using linear regression models and the robustness using the structural equation model.FindingsDigital platform capabilities drive corporate technological innovation through access to strategic information, i.e. strategic information mediates between digital platform capabilities and technological innovation. Business intelligence analytics increases the influence of strategic information on technological innovation.Practical implicationsThis study underlines the importance for companies to construct digital platform capabilities to access strategic information to achieve technological innovation and the role of business intelligence analytics in processing strategic information.Originality/valueThis study finds a new perspective, strategic information, to explain the mechanisms by which digital platform capabilities drive firms’ technological innovation. In addition, the robustness of the resource-based view in understanding digital platform capabilities is stressed.
Adoption of FinTech services amidst COVID-19 pandemic: empirical evidence from Assam
Authors: Das Ankita , Das Debabrata 
Published: December 2022

PurposeThe paper intends to comprehend the pattern of usage of FinTech services among bank customers during the COVID-19 pandemic. The paper also examines the factors influencing the adoption of FinTech services by using the constructs from the technology acceptance model (TAM) together with highlighting the issues faced in using FinTech services in Assam.Design/methodology/approachThe research is empirical in nature. Data have been collected from 1,066 prime earners of the households having a bank account.FindingsThere has been an upsurge in the use of FinTech services in the area of study. Apart from government and private service employees, businessmen, self-employed professionals, many daily-wage earners and agriculturists have also experienced an increase in their frequency of usage of FinTech services thereby making technology-based financial services an indispensable tool in enhancing access, improving inclusivity in the times of crisis and aftermath. Government support, trust, perceived usefulness (PU), attitude and social influence have a positive influence on FinTech adoption; however, perceived risks impact respondents’ trust towards FinTech services thereby requiring necessary measures to evaluate organizations’ preparedness to deal with cyber threats.Originality/valueThe paper provides insight into the factors impacting the adoption of FinTech services to stimulate superior connectivity infrastructure, robust security measures and maintaining financial stability with adequate supervisory and monitoring regulations to enhance trust towards FinTech services during the crisis and aftermath.
Exploring the spatial distribution pattern and influencing factors of Shanghai's cultural functional elements based on the point of interest data
Authors: Li Shuhan , Liu Shilin , Ding Xushi 
Published: December 2022

PurposeTo offer a realistic foundation for urban cultural construction planning, we want to investigate the distribution features of Shanghai's cultural functional elements and examine the distribution patterns in urban space.Design/methodology/approachIn this research, we managed to gather POI geographic data, refined and categorized them to integrate eight categories of cultural functional elements, observed the density and agglomeration, distribution direction and hot and cold spots of overall and each type of cultural functional elements using geospatial analysis methods and then investigated the factors influencing cultural functional elements using geographic detectors.FindingsOur research shows apparent differences between regions and most cultural functional elements are found in the inner city. Second, there are hot and cold spots in the way different cultural functional elements are spread out. Its geographic structure is primarily influenced by third-party traffic service capacity and available time.Originality/valueThis work provides a benchmark for cultural planning in Shanghai by establishing the spatial aggregation impact of cultural functional elements.
Recent topics in the management of herpes zoster
Authors: Asada Hideo 
Published: December 2022

AbstractHerpes zoster is a disease caused by reactivation of the varicella‐zoster virus that has been latently infecting the body and is more common among the elderly. In Japan, the incidence of herpes zoster has been increasing steadily and is expected to increase further in the future. In 2016, the varicella vaccine was expanded to include prevention of herpes zoster, and a new subunit vaccine was also launched in 2020. In recent years, anti‐herpesvirus drugs with novel pharmacological effects have also been introduced, and the environment surrounding the treatment of herpes zoster is entering a new era.
Elevated serum osteopontin levels in patients with severe cutaneous adverse drug reactions
Authors: Suzuki Marie , Koshikawa Sachiko , Watanabe Hideaki , Inomata Naoko , Yamaguchi Yukie , Aihara Michiko , Sueki Hirohiko 
Published: December 2022

AbstractOsteopontin (OPN) was initially described as a protein involved in bone metabolism, but the roles played by OPN in the immune system and allergic reactions have attracted increasing attention. Here, we clarify the OPN‐related dynamics of severe cutaneous adverse drug reactions, and assess whether the OPN level has utility for classifying such reactions and serving as a biomarker of severity. Serum OPN levels in patients with drug‐induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS), Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme‐type drug reaction (EM‐DR) were quantified by ELISA. The OPN sources were analyzed by dual immunofluorescence assay of DIHS, SJS/TEN and EM‐DR biopsy specimens. The serum OPN levels of DIHS/DRESS patients (489.1 ± 37.0 ng/mL) and SJS/TEN patients (508.5 ± 47.8 ng/mL) were significantly higher compared with controls (314.4 ± 14.3 ng/mL; p < 0.001). After treatment, the serum OPN level of DIHS/DRESS patients decreased to that of controls. In addition, OPN levels in DIHS/DRESS patients and SJS/TEN patients were higher than in patients with EM‐DR (Mann–Whitney U test, p < 0.05). However, when the Kruskal–Wallis test was used to compare the OPN levels among the three groups of patients, the difference was not significant (p = 0.055). Dual immunofluorescence assay revealed that T lymphocytes and macrophages were the main OPN sources in DIHS, SJS/TEN and EM‐DR patients. These data suggest that the OPN level can be used to evaluate the severity of inflammation in patients experiencing drug reactions.
An intronic splice‐site variant in MBTPS2 underlies ichthyosis follicularis with atrichia and photophobia syndrome
Authors: Chen Gang , Wang Mengwei , Wang Peiguang , Liang Bo 
Published: December 2022

AbstractIchthyosis follicularis with atrichia and photophobia (IFAP) syndrome is a rare genodermatosis characterized by a classic triad of follicular ichthyosis, alopecia, and photophobia. We report a Chinese patient displaying features of IFAP triad along with painful palmoplantar keratoderma, recurrent infections, periorificial keratotic plaques, nail dystrophy, and pachyonychia. Whole‐exome sequencing revealed an intronic variant (NM_015884.3: exon7:c.970+5G>A) in the gene MBTPS2. Sanger sequencing confirmed that the variant segerated with phenotype in the family. Sequencing of cDNAs derived from the patient indicated the variant introduced a new splice donor site, leading to partial skipping of exon 7 (r.951_970del). An in vitro mini‐gene assay also revealed abnormal splicing of exon 7. This study presents a case complicated with X‐linked IFAP syndrome and Olmsted syndrome, and highlights the significance of using validation assays to identify the pathogenicity of intronic variants in MBTPS2.
Occupational therapists' understanding of supporting physical activity participation when working with children and adolescents: A national survey
Authors: Hill Jessica , Vogler Jessica , Gullo Hannah 
Published: December 2022

AbstractIntroductionPhysical inactivity is a leading risk factor to disease and mortality. Despite the recognised benefits of physical activity, over half of the Australian population are not sufficiently active. For individuals with a disability, inactivity rates are further increased placing them at a higher risk of the negative effects of physical inactivity. Developing healthy lifestyle habits such as physical activity participation in early childhood has been found to be supportive of health behaviours being maintained into adulthood. Physical activity is an occupation said to involve the complex interaction between psychological, social, environmental, and physical factors placing it within the scope of occupation therapy. However, limited research is available exploring what this role looks like in practice.MethodAn online, anonymous survey was developed to better understand how Australian occupational therapists understood physical activity participation, as well as their current and potential role in facilitating regular physical activity participation with their clients. All registered Australian occupational therapists were eligible to participate in this survey, which consisted of both closed and open answered questions.ResultsA total of 43 occupational therapists registered to practice within Australia completed the survey. All participants viewed physical activity as an important occupation for maintaining the health and well‐being of their clients. Participants described the holistic role occupational therapists could play supporting physical activity participation outside of motor skill development. Therapists identified several ways in which a family‐centred, occupation‐based approach could be used to support sustained engagement in physical activity.ConclusionThe findings from this study contribute to our understanding of the role occupational therapy can play supporting physical activity participation for children and adolescents. This sparsely researched area requires more evaluation to ensure intervention is delivered in a way that is most effective.
Do labels matter? Analysis of teachers' self‐efficacy towards the autism spectrum disorder depending on the diagnostic label used (ASD or Asperger's)
Authors: Gómez‐Marí Irene , Pastor‐Cerezuela Gemma , Lacruz‐Pérez Irene , Tárraga‐Mínguez Raúl 
Published: December 2022

Changes in the classification of autism and Asperger's syndrome led to changes in social perception of ASD. Since last criteria, studies indicate higher levels of stigma towards ASD than towards Asperger's. These prejudices are barriers to inclusive education. Thus, it is relevant (1) to evaluate pre‐service teachers' self‐efficacy towards the label of ASD; (2) to evaluate pre‐service teachers' self‐efficacy towards the label of Asperger's and (3) to compare those results to analyse whether the use of different diagnostic labels brings about different levels of self‐efficacy. One hundred and eighty‐six primary education pre‐service teachers participated in the current study. Two adaptations of the Autism Self‐Efficacy Scale for Teachers (ASSET) were used: a version with the label of ‘ASD’ (n = 96) and another for ‘Asperger's’ (n = 90). The scores obtained by the group asked about ASD were high according to the ASSET score range, while the scores obtained by the group asked about Asperger's were medium. After comparing the results, participants asked about the label ASD showed higher levels of self‐efficacy than participants asked about Asperger's. These results could be a consequence of the consolidation of the ASD diagnosis among society and the higher presence of children with ASD in schools and cultural products, among other factors.
Identification of Nocardia and non‐tuberculous Mycobacterium species by MALDI‐TOF MS using the VITEK MS coupled to IVD and RUO databases
Authors: Rodríguez‐Temporal David , Zvezdánova Margarita Estreya , Benedí Pablo , Marín Mercedes , Blázquez‐Sánchez Mario , Ruiz‐Serrano María Jesús , Muñoz Patricia , Rodríguez‐Sánchez Belén 
Published: December 2022

AbstractIdentification of Nocardia and Mycobacterium species by matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry (MALDI‐TOF MS) is still a challenging task that requires both suitable protein extraction procedures and extensive databases. This study aimed to evaluate the VITEK MS Plus system coupled with updated RUO (v4.17) and IVD (v3.2) databases for the identification of Nocardia spp. and Mycobacterium spp. clinical isolates. Sample preparation was carried out using the VITEK MS Mycobacterium/Nocardia kit for protein extraction. From 90 Nocardia spp. isolates analysed, 86 (95.6%) were correctly identified at species or complex level using IVD and 78 (86.7%) using RUO. Only two strains were misidentified as other species pertaining to the same complex. Among the 106 non‐tuberculous Mycobacterium clinical isolates tested from a liquid culture medium, VITEK MS identified correctly at species or complex level 96 (90.6%) isolates in the IVD mode and 89 (84.0%) isolates in the RUO mode. No misidentifications were detected. Although the IVD mode was unable to differentiate members of the M. fortuitum complex, the RUO mode correctly discriminated M. peregrinum and M. septicum. The robustness and accuracy showed by this system allow its implementation for routine identification of these microorganisms in clinical laboratories.
Using imaging methods to assess severe calcinosis in juvenile dermatomyositis: A case report
Authors: Xu Heng , Wang Li , Wei Shufeng , Li Chen , Yuan Kai 
Published: December 2022

AbstractCalcinosis and lipodystrophy are severe complications of juvenile dermatomyositis (JDM). Up to 20% of patients have calcinosis, and the onset of calcinosis usually occurs 1 to 3 years after that of the illness. We report a case of JDM with severe complications of calcinosis and lipodystrophy, and we assess calcinosis using a variety of imaging methods. To evaluate the patient's inflammatory state, bone scintigraphy was performed, which demonstrated increased uptake in the right scapula, in addition, multiple calcifications are present subcutaneously on the shoulder and back, and inflammatory imaging features are also present in the right knee joint.