bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI KOMUNIKASI DINAS PERHUBUNGAN DALAM MENSOSIALISASIKAN APLIKASI SIP TB (TRANSBATAM) DI KOTA BATAM
Authors: Khotimah Chusnul Khotimah 
Published: September 2023

Transportation needs are increasing in Batam City. To make it easier for the community, the Batam City Transportation Service has supported the availability of public transportation facilities. Public transportation available in Batam City is quite diverse including Trans Batam (TB), public transportation (City Transportation), city buses and others. However, until now Batam City is still very minimal in providing information services regarding transportation, such as routes, departure schedules, area coverage and others. Based on the research conducted, it has been found various problems experienced by public transportation users in Batam. The main problem found in this case is the lack of detailed information about public transportation in Batam City. Therefore the Department of Transportation innovates to design an application called SIP TB with the hope that the output of the application is in accordance with the needs and desires of users. The method used in this study is a qualitative method using data collection techniques, observations and interviews. In this study, proving that the SIP TB application can provide convenience to users of public transportation (especially Trans Batam) where people can access information about Trans Batam transportation in real time.

Keywords: SIP TB application; Department of Transportation; Media Channels; Communication Strategy; Transportation.
POLA KOMUNIKASI ANTARUMAT BERAGAMA DALAM MENCIPTAKAN KERUKUNAN DI MAHA VIHARA DUTA MAITREYA KOTA BATAM
Authors: Agustina Risma Maya , Rorong Michael Jibrael 
Published: September 2023

Communications is one of the normal things for humans life. The result of this research is that the pattern of inter-religious communications formed at Maha Vihara Duta Maitreya Batam uses personal communications and gorup communication with the aim of maintaining inter-religious tolerance in communcating with the establishment of this communication.namely the occurence of two-way communication and the occurence of feedback between the sender of the message and the recipient of the message. In this communication pattern, communication is established between religious communities at the Maha Vihara Duta Maitreya, which is created at major monastic events such as Chinese New Year Celebrations, Vesak, and Moon Cake events.

Keywords: Communications, Interreligious communications, Harmony, Patterns of communication.
Analisis Semiotika Pesan Moral Film Ku Kira Kau Rumah
Authors: BERLIANA MAHDALENA , Abidin Sholihul 
Published: September 2023

The existence of films in the midst of society has a different character compared to other media Apart from being an effective mass media in conveying ideas and ideas, film is also a medium to express an art to express a creativity and to describe human life. The film Ku Kira Kau Rumah tells the story of a girl named Niskala who suffers from bipolar disorder, a mental health issue that can relapse and attack her at any time. The purpose of this study is to find out the moral message represented by the film Ku Kira Kau Rumah. The research method used is a qualitative research method. Qualitative research is research whose data is in the form of statements or statements and begins with an interpretive approach. By using the semiotic approach of Roland Barthes perspective through denotation, connotation and myth. The results showed that Niskala's bipolar disorder was a mental health disorder, and she often experienced mood swings or very rapid mood changes. The moral message contained in the film "Ku Kira Kau Rumah" consists of relationships between family, friends, and partners, which include attention, full of hope, full of affection, honesty, perseverance, wisdom, openness, trust in others, and humility. Conclusion Moral values in Ku kira Kau Rumah can provide a teaching about family, friendship, courage in pursuing dreams and appreciating every opportunity, trust and sincerity so that the audience can face life with optimism, and appreciate an important relationship in life and not give up easily.

Keywords: Film, Moral Message, Semiotics Perspective Ferdinand De Saussure
ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI MINAT MAHASISWA AKUNTANSI DALAM PEMILIHAN KARIR SEBAGAI AKUNTAN PUBLIK
Authors: Imaniah Nur , Purba Mortigor Afrizal 
Published: September 2023

This study aims to examine the effect of financial rewards or salary, work environment, professional training, professional recognition, and social values on the interest of accounting students in choosing a career to become a public accountant. This research method is a purposive sample technique. This research technique was conducted by distributing questionnaires to accounting students in Batam City. Data analysis using IBM SPSS 22.00 application. The results of this study are that financial rewards and work environment have a positive effect on the interest of accounting students in decide a career as a public accountant. Meanwhile, professional training, professional recognition and social values have no significant effect.
Keyword: Financial rewards, work environmental,professional training,professional recognitionan, social value
Pengaruh Persepsi, Pengetahuan Akuntansi, dan Skala Usaha terhadap Pengggunaan Sistem Informasi Akuntansi Pada Usaha Mikro, Kecil, dan Menengah
Authors: Putri Rizky Rahmalia , Effendi Syahril 
Published: September 2023

ABSTRACT
This study aims to determine the effect of the effect of MSMES Actors perceptions of accounting on the use of accounting information system, the effect of accounting knowledge on the use of accounting information system, and the effect of business scale on the use of accounting information system. The sample of this research is SMEs in the city of Batam as many as 100 SMES. The hypothesis testing technique used is multiple linear regression and multiple coefficients of determination, which are used to measure the effect of more than one independent variable on the depent variable through the validity and reliability test stages, the classical assumption test of multicollinearity, heteroscedasticity, auto corellation, t test; F test. The result of thus research indicate that (1) there is no positive influence of the perception of MSME actors on the use of accounting information system. (2) there is no positive effect of accounting knowledge on the use of accounting information system. (3) there is a positive effect of business scale on the use of accounting information system. (4) there is a positive influence on the perception of MSME actors about accounting, accounting knowledge, and business scale on the use of accounting information system.

Keywords: Perceptions of MSME on Accounting; Accounting Knowledge; Business Scale; Use of Accounting Information System.
PENGARUH DISIPLIN KERJA DAN LOYALITAS KERJA TERHADAP KINERJA KARYAWAN PADA PT. SATRIA GLOBAL PERSADA
Authors: Amelia Wulan , Wasiman Wasiman 
Published: September 2023

The research was conducted to see the influence exerted on employee performance by work discipline and work loyalty at PT. Satria Global Persada. the method in this study used quantitative methods with the SPSS version 27 tool in associative (casual) form by distributing questionnaires to obtain data. the population in this study are all employees who work at PT. Satria Global Persada with a sample of 100 respondents. testing the quality of the data using the validates test and reliability test, testing the classical assumptions using the normality test, multicollinearity test and heteroscedasticity test and the influence test using multiple linear regression analysis and analysis of the coefficient of determination (R2). then to test the hypothesis using the t test and f test. The results of this study indicate that work discipline and work loyalty have an effect of 55.8% on employee performance, while the remaining 44.2% are influenced by other variables outside of this study.

Keywords: Work Discipline, Work Loyalty, Employee Performance
Incidence of cisplatin-induced ototoxicity in adult cancer patients based on audiometric confirmation of patient self-report
Authors: Voruz François , Vuilleumier Aurélie , Migliorini Denis , Nacher-Soler German , Rousset Francis , De Maesschalck Thibault , Senn Pascal 
Published: September 2023

IntroductionRobust clinically relevant epidemiological and audiological data are needed to prepare for future clinical trials aiming at preventing cisplatin-induced ototoxicity in this suffering cancer population. We assessed the incidence, severity, and potential risk factors of symptomatic cisplatin-induced hearing loss in a large cohort of adults.MethodsRetrospective cohort study at a tertiary care university hospital. The study group included consecutive patients over 18 years old treated with cisplatin-based chemotherapy without concomitant inner ear radiotherapy or other ototoxic medication. Every participant underwent baseline pretreatment audiometry and was asked for audiological symptoms (tinnitus or subjective hearing loss) during the treatment. If symptomatic, comparative standard audiometry (0.125 to 8 kHz) was performed. Hearing loss was defined by a threshold shift ≥15 dB HL in at least one of the tested frequencies.ResultsA total of 401 cancer patients (59% males) with a mean age of 56 years (range 18-80) were included. Eighty-one patients (20%) developed symptomatic hearing loss, predominantly affecting the high frequencies from 4 to 8 kHz. Among them, 49 (60%) experienced simultaneous new-onset tinnitus. None of the analyzed potential risk factors (age, sex, smoking, hypertension, diabetes, dyslipidemia, chemotherapeutic regimen, and cumulative cisplatin dose) was statistically correlated with hearing loss.DiscussionAt least 1 out of 5 patients treated with cisplatin developed audiological symptoms associated with audiometric hearing loss within the 0.125 to 8 kHz range, for which new-onset tinnitus is a sensitive symptom. Not all audiological symptoms are accompanied by audiometric change. No predisposing factor could be identified. Standardized audiological monitoring before and during cisplatin-based chemotherapy allows quantitative assessment of early audiometric signs of ototoxicity, offering to optimize anticancer therapy while minimizing morbidity in a multidisciplinary setting.
Incidence, associated factors, and outcomes of acute kidney injury following placement of antibiotic bone cement spacers in two-stage exchange for periprosthetic joint infection: a comprehensive study
Authors: Li Zhuo , Maimaiti Zulipikaer , Yang Fan , Fu Jun , Li Zhi-Yuan , Hao Li-Bo , Chen Ji-Ying , Xu Chi 
Published: September 2023

BackgroundTwo-stage exchange with placement of antibiotic cement spacer (ACS) is the gold standard for the treatment of chronic periprosthetic joint infection (PJI), but it could cause a high prevalence of acute kidney injury (AKI). However, the results of the current evidence on this topic are too mixed to effectively guide clinical practice.MethodsWe retrospectively identified 340 chronic PJI patients who underwent the first-stage exchange with placement of ACS. The Kidney Disease Improving Global Outcomes guideline was used to define postoperative AKI. Multivariate logistic analysis was performed to determine the potential factors associated with AKI. Furthermore, a systematic review and meta-analysis on this topic were conducted to summarize the knowledge in the current literature further.ResultsIn our cohort, the incidence of AKI following first-stage exchange was 12.1%. Older age (per 10 years, OR= 1.509) and preoperative hypoalbuminemia (OR= 3.593) were independent predictors for postoperative AKI. Eight AKI patients progressed to chronic kidney disease after 90 days. A meta-analysis including a total of 2525 PJI patients showed the incidence of AKI was 16.6%, and AKI requiring acute dialysis was 1.4%. Besides, host characteristics, poor baseline liver function, factors contributing to acute renal blood flow injury, and the use of nephrotoxic drugs may be associated with the development of AKI. However, only a few studies supported an association between antibiotic dose and AKI.ConclusionAKI occurs in approximately one out of every six PJI patients undergoing first-stage exchange. The pathogenesis of AKI is multifactorial, with hypoalbuminemia could be an overlooked associated factor. Although the need for acute dialysis is uncommon, the fact that some AKI patients will develop CKD still needs to be taken into consideration.
Telehealth nursing interventions for phenotypes of older adults with COPD: an exploratory study
Authors: Arnaert A. , Ahmed A.M.I. , Debe Z. , Charbonneau S. , Paul S. 
Published: September 2023

IntroductionInconclusive results exist around the effectiveness of telemonitoring for patients with COPD, and studies recommended conducting subgroup analyses to identify patient phenotypes that could benefit from these services. This exploratory study investigated what type of COPD patients were receiving which type of telenursing interventions more frequently using the telemonitoring platform.MethodsA sample of 36 older adults with COPD were receiving telenursing services for 12 months and were asked to answer five COPD-symptom related questions and submit their vital signs daily.ResultsFindings revealed two phenotypes of older adults for whom the frequency of telenursing calls and related interventions differed. Although no statistically significant differences were observed in participants' GOLD grades and hospitalizations, cluster one participants used their COPD action plan significantly more frequently, and were in frequent contact with the telenurse.DiscussionIt is paramount that further research is needed on the development of patient phenotypes who may benefit from telemonitoring.
Factors affecting male-to-female ratio at birth in frozen-thawed embryo transfer cycles: a large retrospective cohort study
Authors: Du Tong , Xie Qin , Ye Jing , Wang Xindi , Qiu Jiaxin , Yan Zheng , Zhang Suqun , Zhao Dong , Lin Jiaying , Li Bin 
Published: September 2023

BackgroundICSI (intracytoplasmic sperm injection) leads to a reduced male-to-female ratio at birth, whereas blastocyst transfer results in an increased male-to-female ratio. However, limited knowledge exists regarding the impact of these factors on the live birth rate for each gender. This study aimed to investigate the influence of patient characteristics and treatment parameters on the live birth rate for each gender, as well as the ultimate male-to-female ratio at birth in frozen-thawed embryo transfer (FET) cycles.MethodThis retrospective cohort study involved a total of 28,376 FET cycles and 9,217 subsequent deliveries, spanning from January 2003 to December 2015. The study consisted of two parts. First, logistic regression models were constructed to determine the factors influencing the male-to-female ratio among babies born after FET. Second, we aimed to investigate the mechanisms underlying this sex ratio imbalance by analyzing data from all transfer cycles. Generalized estimated equations were employed to assess the impact of risk factors on rates of male and female live births separately.ResultsICSI resulted in a lower proportion of male offspring compared to in vitro fertilization (IVF) (50.1% vs. 53.7%, aOR: 0.87, 95% CI: 0.80-0.96). Conversely, blastocyst transfer yielded a higher proportion of male offspring than cleavage-stage embryo transfer (58.7% vs. 51.6%, aOR: 1.32, 95% CI: 1.17-1.48). Analysis of all cycles indicated that ICSI resulted in a reduced likelihood of male live birth in comparison to IVF (19.8% vs. 21.6%, aOR: 0.90, 95% CI: 0.83-0.97). However, the transfer of blastocysts rather than cleavage-stage embryos not only increased the chance of male live birth (26.9% vs. 20.2%, aOR: 1.70, 95% CI:1.56-1.85) but also facilitated female live birth (20.3% vs. 19.3%, aOR: 1.26, 95% CI: 1.15-1.39).ConclusionICSI was associated with a reduction in the male-to-female sex ratio and a lower rate of male live births, while blastocyst transfer was associated with an increased male-to-female sex ratio at birth and a higher rate of male live births.
Long-term glycemic variability predicts compromised development of heart failure with improved ejection fraction: a cohort study
Authors: Yang Chen Die , Chen Jia Wei , Quan Jin Wei , Shu Xin Yi , Feng Shuo , Aihemaiti Muladili , Ding Feng Hua , Shen Wei Feng , Lu Lin , Zhang Rui Yan , Wang Xiao Qun 
Published: September 2023

BackgroundA substantial portion of heart failure (HF) patients adherent to guideline-directed medical therapies have experienced improved ejection fraction (EF), termed HFimpEF. Glycemic variability (GV) has emerged as a critical cardiometabolic factor. However, the relation between long-term GV and the incidence of HFimpEF is still unclear.MethodsA total of 591 hospitalized HF patients with reduced EF (HFrEF, EF≤ 40%) admitted from January 2013 to December 2020 were consecutively enrolled. Repeat echocardiograms were performed at baseline and after around 12 months. The incidence of HFimpEF, defined as (1) an absolute EF improvement ≥10% and (2) a second EF &gt; 40% and its association with long-term fasting plasma glucose (FPG) variability were analyzed.ResultsDuring a mean follow-up of 12.2 ± 0.6 months, 218 (42.0%) patients developed HFimpEF. Multivariate analysis showed FPG variability was independently associated with the incidence of HFimpEF after adjustment for baseline HbA1c, mean FPG during follow-up and other traditional risk factors (odds ratio [OR] for highest vs. lowest quartile of CV of FPG: 0.487 [95% CI 0.257~0.910]). Evaluation of GV by alternative measures yielded similar results. Subgroup analysis revealed that long-term GV was associated with HFimpEF irrespective of glycemic levels and diabetic conditions.ConclusionsThis study reveals that greater FPG variability is associated with compromised development of HFimpEF. A more stable control of glycemic levels might provide favorable effects on myocardial functional recovery in HF patients even without diabetes.
IL-21/23 axis modulates inflammatory cytokines and RANKL expression in RA CD4+ T cells via p-Akt1 signaling
Authors: Bhattacharya Gargee , Sengupta Soumya , Jha Rohila , Shaw Shubham K. , Jogdand Gajendra M. , Barik Prakash K. , Padhan Prasanta , Parida Jyoti R. , Devadas Satish 
Published: September 2023

IntroductionCD4+ T cells are critically involved in the pathogenesis of Rheumatoid Arthritis; an autoimmune disorder characterized by joint inflammation and bone degeneration. In this study, we focused on the critical role of cytokines, IL-21 and IL-23 in facilitating the aberrant status of RA Th17-like cells and report their significant contribution(s) in modulating the expression of inflammatory cytokines and RANKL.MethodsBlood and synovial fluid collected from a total of 167 RA patients and 25 healthy volunteers were assessed for various inflammatory markers and RANKL expression in plasma and CD4+ T cells. Subsequent ex vivo studies examined the role of specific cytokines, IL-21 and IL-23 in mediating inflammation and RANKL upregulation by blocking their expression with neutralizing antibodies in RA CD4+ T cells and terminally differentiated human Th17 cells. Further, the role of p-Akt1 as a signalling target downstream of IL-21 and IL-23 was evinced with IL-21 and IL-23 inhibition and phospho Akt-1/2 kinase inhibitor.ResultsOur observations highlighted the augmented inflammatory cytokine levels in plasma and an aberrant CD4+ T cell phenotype expressing exaggerated inflammatory cytokines and membrane RANKL expression in RA as opposed to healthy controls. Neutralization of either IL-21 or IL-23 (p19 and p40) or both, resulted in downregulation of the cytokines, TNF-α, IFN-γ and IL-17 and RANKL expression in these cells, signifying the critical role of IL-21/23 axis in modulating inflammation and RANKL. Subsequent dissection of the signaling pathway found p-Akt1 as the key phosphoprotein downstream of both IL-21 and IL-23, capable of increasing inflammatory cytokines and RANKL production.DiscussionOur findings unequivocally identify IL-21/23 axis in RA CD4+ T cells as a key regulator dictating two critical processes i.e. exaggerated inflammation and higher RANKL expression and provide critical targets in their downstream signalling for therapeutic approaches.
Association between immunoglobulin G N-glycosylation and lupus nephritis in female patients with systemic lupus erythematosus: a case-control study
Authors: Lu Xinxia , Wang Liangao , Wang Meng , Li Yuejin , Zhao Qinqin , Shi Yanjun , Zhang Yujing , Wang Yingjie , Wang Wei , Ji Long , Hou Haifeng , Li Dong 
Published: September 2023

BackgroundLupus nephritis (LN) is a crucial complication of systemic lupus erythematosus (SLE) and has important clinical implications in guiding treatment. N-glycosylation of immunoglobulin G (IgG) plays a key role in the development of SLE by affecting the balance of anti-inflammatory and proinflammatory responses. This study aimed to evaluate the performance of IgG N-glycosylation for diagnosing LN in a sample of female SLE patients.MethodsThis case-control study recruited 188 women with SLE, including 94 patients with LN and 94 age-matched patients without LN. The profiles of plasma IgG N-glycans were detected by hydrophilic interaction chromatography with ultra-performance liquid chromatography (HILIC-UPLC). A multivariate logistic regression model was used to explore the associations between IgG N-glycans and LN. A diagnostic model was developed using the significant glycans as well as demographic factors. The performance of IgG N-glycans in the diagnosis of LN was evaluated by receiver operating characteristic (ROC) curve analysis, and the area under the curve (AUC) and its 95% confidence interval (CI) were calculated.ResultsThere were significant differences in 9 initial glycans (GP2, GP4, GP6, GP8, GP10, GP14, GP16, GP18 and GP23) between women with SLE with and without LN (P &lt; 0.05). The levels of sialylated, galactosylated and fucosylated glycans were significantly lower in the LN patients than in the control group, while bisected N-acetylglucosamine (GlcNAc) glycans were increased in LN patients (P &lt; 0.05). GP8, GP10, GP18, and anemia were included in our diagnostic model, which performed well in differentiating female SLE patients with LN from those without LN (AUC = 0.792, 95% CI: 0.727 to 0.858).ConclusionOur findings indicate that decreased sialylation, galactosylation, and core fucosylation and increased bisecting GlcNAc might play a role in the development of LN by upregulating the proinflammatory response of IgG. IgG N-glycans can serve as potential biomarkers to differentiate individuals with LN among SLE patients.