bluuebunny/crossref_metadata_2025_split huggingface dataset:
Willingness to accept or refuse mandibular implant overdenture treatment: A prospective study on edentulous enrolled in a clinical trial
Authors: Leles Cláudio Rodrigues , Nascimento Lays Noleto , Silva Jésio Rodrigues , de Paula Marcella Silva , Curado Thalita Fernandes Fleury , McKenna Gerald , Schimmel Martin 
Published: February 2023

AbstractBackgroundSeveral complete denture wearers have major complaints and may be benefitted from implant treatment. However, the factors that shape the demand for and utilization of implants need further investigation.ObjectiveThe aim was to evaluate edentulous patient's willingness to accept or refuse the offer and provision of implant‐retained treatment.MethodsAs part of a clinical trial, edentulous subjects were offered a mandibular overdenture retained by four mini‐implants opposing a conventional maxillary denture. Treatment was offered without any financial costs for the patients. Patients' level of interest in receiving treatment was assessed using a 5‐point Likert scale, and they were asked to respond to a list of reasons that led to their decision to accept or refuse implants. Those who refused implants received conventional prosthodontic interventions as required, and those who accepted implant treatment underwent surgical planning and implant placement.ResultsOf 175 eligible subjects, 147 accepted the offer of treatment and were invited to take part in the study (69.4% women, mean age 67.4 ± 10.0 years). Overall, 111 patients (75.5%) expressed a positive intention to undergo implant treatment at the initial contact. Implant treatment was performed for 56.3% (9/16) of those who answered ‘probably yes’ about their level of interest in implant treatment on the Likert scale, and 69.6% (64/92) of ‘certainly yes’ (p < .001). Older subjects were less likely to receive implants (OR = 0.93; p = .036), whilst those with a positive intention towards implants (OR = 3.15; p = .001), those previously treated by the dental team (OR = 7.89; p < .001), and who actively demanded implants (OR = 18.1; p < .001) were more likely to accept treatment. Improved chewing was the most common reason for accepting implants, whilst fear of surgery was the most reported reason for refusal.ConclusionRefusal of implants was high among edentate patients even when financial costs were removed. Patients' initial attitude towards acceptance is a key factor in the demand for and uptake of implant therapy.
Correlations between sleep architecture and sleep‐related masseter muscle activity in children with sleep bruxism
Authors: Restrepo Claudia , Lobbezoo Frank , Castrillon Eduardo , Svensson Peter , Santamaria Adriana , Manfredini Daniele 
Published: February 2023

AbstractBackgroundSleep bruxism (SB) occurring during No‐REM (nREM) sleep and increase in microarousals per hour have been described in adults, but not in children.ObjectiveTo assess the correlation between sleep architecture and masseter muscle activity related to sleep bruxism (SB/MMA) in children.Materials and methodsForty‐three children aged 7–12 years (mean age: 9.4 ± 1.3) with confirmed SB underwent a two‐night polysomnographic (PSG) study in a sleep laboratory, for accommodation (first night) and data collection (second night). Data on sleep architecture (total sleep duration (TSD), sleep efficiency (SE), sleep onset latency (SOL), REM and nREM sleep duration and proportion and microarousals/hour during REM and nREM sleep) and episodes/hour of SB/MMA were recorded. Single and multiple‐variable linear regression analyses were performed to assess the correlation between data on sleep architecture (predictors) and SB/MMA (dependent variable).ResultsShorter TSD, REM and nREM stage 1 sleep duration, longer SOL and more microarousals/hour during REM and nREM sleep were found to be positive predictors of SB/MMA in children in the multiple‐variable regression analysis (R2 = 0.511).ConclusionWithin the limitations of this study, it can be concluded that SB/MMA is correlated with altered sleep architecture in children (shorter total sleep duration (TSD), shorter nREM and REM sleep and higher microarousals during REM and nREM sleep). Nevertheless, the clinical significance of these findings need to be demonstrated in future studies.
Safety of stimulant medications for attention deficit hyperactivity disorder in paediatric congenital heart disease
Authors: Chung Lorraine M , Hariharan Gopakumar , Varma Suraj 
Published: February 2023

AimTo review current literature regarding the safety of stimulant medications for treatment of attention deficit hyperactivity disorder in paediatric congenital heart disease (CHD) patients.MethodsEmbase, MEDLINE complete, CINAHL complete and Psychology and Behavioural Sciences Collection were searched for relevant articles from January 1980 to July 2022.ResultsOne hundred and three articles were identified during the initial search after removal of duplicates. Thirty‐five articles were selected for review and 11 were included as relevant to the clinical question.ConclusionsStimulant medications are safe in patients with underlying CHD. In mild congenital cardiac conditions (ventricular septal defect, atrial septal defect and isolated semilunar valve disease), paediatricians can safely initiate stimulant therapy. With complex CHD cases, cardiology opinion is recommended prior to starting stimulants.
pH‐shifting alters textural, thermal, and microstructural properties of mung bean starch–flaxseed protein composite gels
Authors: Min Cong , Zhang Chong , Pu Huayin , Li Hongliang , Ma Wenhui , Kuang Jiwei , Huang Junrong , Xiong Youling L. 
Published: February 2023

AbstractThe objective of this study was to investigate the effect of pH‐shifting on the textural and microstructural properties of mung bean starch (MBS)‐flaxseed protein (FP) composite gels. Results showed that different pH‐shifting treatments caused changes in hydrogen bond interactions and secondary structures in composite gels, leading to the formation of loose or compact gel networks. The pH 2‐shifting modified protein and starch molecules with shorter chains tended to form smaller intermolecular aggregates, resulting in the formation of a looser gel network. For pH 12‐shifting treatment, conformational change of FP caused the unfolding of protein and the exposure of more hydrophobic groups, which enhanced the hydrogen bond and hydrophobic interactions between polymers, contributing to the formation of a compact gel network. Furthermore, pH 12‐shifting improved the water‐holding capacity (WHC), storage modulus, and strength of gels, while pH 2‐treated gels exhibited lower WHC, hardness, and gumminess due to the degradation of MBS and denaturation of FP caused by extreme acid condition. These findings suggest that pH‐shifting can alter the gel properties of bi‐polymeric starch‐protein composite systems by affecting the secondary structures of proteins and the hydrogen bonding between the polymers, and provide a promising way for a wide application of FP in soft gel‐type food production.
Utility of a haemoglobin test of gingival crevicular fluid: A multicentre, observational study
Authors: Ito Hiroshi , Numabe Yukihiro , Hashimoto Shuichi , Sekino Satoshi , Murakashi Etsuko , Ishiguro Hitomi , Sasaki Daisuke , Yaegashi Takashi , Takai Hideki , Mezawa Masaru , Ogata Yorimasa , Watanabe Hisashi , Izumi Yuichi , Kido Jun‐Ichi , Hiroshima Yuka , Nagata Toshihiko 
Published: February 2023

AbstractObjectiveThe purpose of this study was to verify the accuracy and utility of clinical parameters (plaque index, gingival crevicular fluid volume, probing depth, clinical attachment level, bleeding on probing and gingival index) and biochemical parameters (aspartate aminotransferase, protein and haemoglobin) in a longitudinal analysis during the supportive periodontal therapy period.Subjects and MethodsA total of 279 test sites of 128 patients were investigated clinically and biochemically. After the first examination of clinical and biochemical parameters, periodontal support treatments were administered immediately and performed once every three months up to the second examination.ResultsAll of the clinical and biochemical parameters were significantly lower at the second examination than at the first, except for the plaque index and bleeding on probing. Of these parameters, in particular, aspartate aminotransferase and haemoglobin in the gingival crevicular fluid were significantly reduced compared to those of the first examination in both the ≤4 and ≥5 mm probing depth groups, and they clearly suggested that periodontitis tended to recover.ConclusionAdding the haemoglobin test to the bleeding on probing test strongly improves the accuracy of measurement of clinical parameters after periodontal treatment.
Faster induction of photosynthesis increases biomass and grain yield in glasshouse‐grown transgenic Sorghum bicolor overexpressing Rieske FeS
Authors: Ermakova Maria , Woodford Russell , Taylor Zachary , Furbank Robert T. , Belide Srinivas , von Caemmerer Susanne 
Published: February 2023

SummarySorghum is one of the most important crops providing food and feed in many of the world's harsher environments. Sorghum utilizes the C4 pathway of photosynthesis in which a biochemical carbon‐concentrating mechanism results in high CO2 assimilation rates. Overexpressing the Rieske FeS subunit of the Cytochrome b6f complex was previously shown to increase the rate of photosynthetic electron transport and stimulate CO2 assimilation in the model C4 plant Setaria viridis. To test whether productivity of C4 crops could be improved by Rieske overexpression, we created transgenic Sorghum bicolor Tx430 plants with increased Rieske content. The transgenic plants showed no marked changes in abundances of other photosynthetic proteins or chlorophyll content. The steady‐state rates of electron transport and CO2 assimilation did not differ between the plants with increased Rieske abundance and control plants, suggesting that Cytochrome b6f is not the only factor limiting electron transport in sorghum at high light and high CO2. However, faster responses of non‐photochemical quenching as well as an elevated quantum yield of Photosystem II and an increased CO2 assimilation rate were observed from the plants overexpressing Rieske during the photosynthetic induction, a process of activation of photosynthesis upon the dark–light transition. As a consequence, sorghum with increased Rieske content produced more biomass and grain when grown in glasshouse conditions. Our results indicate that increasing Rieske content has potential to boost productivity of sorghum and other C4 crops by improving the efficiency of light utilization and conversion to biomass through the faster induction of photosynthesis.
LAZY3 interacts with LAZY2 to regulate tiller angle by modulating shoot gravity perception in rice
Authors: Cai Yueyue , Huang Linzhou , Song Yuqi , Yuan Yundong , Xu Shuo , Wang Xueping , Liang Yan , Zhou Jie , Liu Guifu , Li Jiayang , Wang Wenguang , Wang Yonghong 
Published: February 2023

SummaryStarch biosynthesis in gravity‐sensing tissues of rice shoot determines the magnitude of rice shoot gravitropism and thus tiller angle. However, the molecular mechanism underlying starch biosynthesis in rice gravity‐sensing tissues is still unclear. We characterized a novel tiller angle gene LAZY3 (LA3) in rice through map‐based cloning. Biochemical, molecular and genetic studies further demonstrated the essential roles of LA3 in gravity perception of rice shoot and tiller angle control. The shoot gravitropism and lateral auxin transport were defective in la3 mutant upon gravistimulation. We showed that LA3 encodes a chloroplast‐localized tryptophan‐rich protein associated with starch granules via Tryptophan‐rich region (TRR) domain. Moreover, LA3 could interact with the starch biosynthesis regulator LA2, determining starch granule formation in shoot gravity‐sensing tissues. LA3 and LA2 negatively regulate tiller angle in the same pathway acting upstream of LA1 to mediate asymmetric distribution of auxin. Our study defined LA3 as an indispensable factor of starch biosynthesis in rice gravity‐sensing tissues that greatly broadens current understanding in the molecular mechanisms underlying the starch granule formation in gravity‐sensing tissues, and provides new insights into the regulatory mechanism of shoot gravitropism and rice tiller angle.
Urogenital presentation of a male patient with focal dermal hypoplasia
Authors: Nguyen Khoa , Sosa Valentina 
Published: February 2023

AbstractFocal dermal hypoplasia (FDH) is a rare X‐linked dominant syndrome characterized by streaky cutaneous atrophy in a blaschkoid distribution, skeletal dysplasias, and ocular abnormalities. Here, we report hypospadias and chordee identified in a male patient with molecularly confirmed FDH. This report highlights a new clinical manifestation of male patients with FDH.
Optimizing the Seasonal Shade and Ultraviolet Protection of a Suburban Playground by Utilization of the Playground Shade Index
Authors: Downs Nathan , Butler Harry , Parisi Alfio , Beckman‐Downs Melanie , Igoe Damien 
Published: February 2023

AbstractThe Playground Shade Index (PSI) is introduced as a design metric for assessing the shade and solar ultraviolet (UV) protection provided by eight different cloth weave shade structures currently utilized in public playgrounds across a regional city located in southern Queensland, Australia. The PSI, expressing the ratio of available ambient solar UV exposure relative to the UV exposure received by a shaded 184 m2 playground surface over a whole day in midsummer and midwinter, is used to determine the best design and aspect of all eight existing structures. Unlike subjective shade audits that may only consider the type of shade structure, the number and characteristics of surrounding trees, and surface materials available at a given site, the PSI considers, in addition to previous factors, the available sky fraction and the direct solar UV contribution underneath the shade structure over a full day. By considering the in situ UV protection characteristics of the shade structure, the PSI has demonstrated its value as a robust design metric. Of the eight shade structure styles examined, this research presents the most likely structure best suited for UV protection over the two solar UV extremes in summer and winter, including optimal structure aspect.
Comparison of sonographic and CT findings for the identification of renal nodules in dogs and cats
Authors: Rossi Federica , Gianni Beatrice , Marconato Laura , Sabattini Silvia , Caleri Elvanessa , Mattolini Mirko , Camosci Veronica , Carozzi Gregorio 
Published: February 2023

AbstractUltrasonography (US) and computed tomography (CT) are used to diagnose neoplastic and non‐neoplastic focal renal lesions in dogs and cats; however, comparative studies between these two diagnostic tools are lacking. The aim of this retrospective, methods comparison study was to evaluate and compare the performance of US compared to CT in identifying at least one renal nodule in animals with confirmed focal renal lesions. Imaging studies of animals with uni‐ or bilateral renal nodules smaller than 3 cm that underwent both US and CT and that had a pathologically confirmed diagnosis were reviewed. Animals with renal cysts and infarcts were excluded. Recorded features for both modalities included the following: shape, size, number, localization, margins, renal profile. For CT only, recorded features also included attenuation (HU) and pattern of enhancement. For US only, recorded features also included echogenicity, echostructure, and rate of visibility. Final diagnosis was obtained by cytology or histopathology. Using CT, lesions were identified in all 39 (100%) kidneys of 18 dogs and seven cats. Most lesions were multiple, cortical, well‐defined, iso‐attenuating (precontrast), hypo‐attenuating, and moderately enhancing (postcontrast). Using US, lesions were identified in 29 of 39 (74%) kidneys. Overall, nine (31%) lesions were poorly visible; 10 (26%) kidneys appeared normal; in 17 (59%) organs, lesions’ number was underestimated. Isoechoic, non‐protruding lesions were difficult to identify by US. Ultrasonography underestimated renal lesions compared to CT in 59% of the kidneys (P = 0.001). Final diagnoses included metastatic disease (n = 16), infiltration by feline lymphoma (n = 4), primary neoplasia (n = 3), and non‐neoplastic benign lesions (n = 2).
Factors affecting prognosis in canine subcutaneous mast cell tumors: 45 cases
Authors: Cherzan Nathan L. , Fryer Katy , Burke Blaise , Farrelly John 
Published: February 2023

AbstractObjectiveTo evaluate the clinical outcome of subcutaneous mast cell tumors (SQMCT) and to identify clinical and histological characteristics of more aggressive disease.Study designRetrospective study.AnimalsForty‐five dogs with 48 SQMCTs.MethodsMedical records were reviewed (2011–2021) for patient information, clinical, and histopathological data including multinucleation, necrosis, invasion into local muscle, an infiltrative growth pattern, tumor grade (if listed), mitotic index, and surgical margins. The presence of local recurrence, lymph node metastasis, survival time, and other parameters evaluating patient outcome were also recorded.ResultsLocal recurrence occurred in 17.8% (8/45) of dogs, 11.1% (5/45) developed metastatic recurrence, and 26.7% (12/45) developed lymph node metastasis. Dogs with lymph node metastases had a median disease‐free interval (DFI) of 194 days (18–1864), while median DFI was not reached for dogs without lymph node metastasis (p = .0012). Median survival time for dogs with lymph node metastasis was 551 days (110–2050) compared to 1722 days (10–1722) without metastasis (p = .0432). Local recurrence resulted in a significantly shorter median survival time of 551 days (80–2050) compared to 1722 days (10–1722) for dogs without local recurrence (p = .0038). Dogs with infiltrative tumors had a median DFI of 268 days (3–1722) and DFI for dogs without an infiltrative pattern had not reached median at 1864 days (10–1864) (p = .011).ConclusionLymph node metastasis decreased disease‐free interval and survival.Clinical significanceSubcutaneous mast cell tumors may be a more aggressive disease than previously reported.
Rhombohedral-stacked bilayer transition metal dichalcogenides for high-performance atomically thin CMOS devices
Authors: Li Xuefei , Shi Xinhang , Marian Damiano , Soriano David , Cusati Teresa , Iannaccone Giuseppe , Fiori Gianluca , Guo Qi , Zhao Wenjie , Wu Yanqing 
Published: February 2023

Van der Waals coupling with different stacking configurations is emerging as a powerful method to tune the optical and electronic properties of atomically thin two-dimensional materials. Here, we investigate 3R-stacked transition-metal dichalcogenides as a possible option for high-performance atomically thin field-effect transistors (FETs). We report that the effective mobility of 3R bilayer WS
2
(WSe
2
) is 65% (50%) higher than that of 2H WS
2
(WSe
2
). The 3R bilayer WS
2
n-type FET exhibits a high on-state current of 480 μA/μm at
V
ds
= 1 V and an ultralow on-state resistance of 1 kilohm·μm. Our observations, together with multiscale simulations, reveal that these improvements originate from the strong interlayer coupling in the 3R stacking, which is reflected in a higher conductance compared to the 2H stacking. Our method provides a general and scalable route toward advanced channel materials in future electronic devices for ultimate scaling, especially for complementary metal oxide semiconductor applications.
Interval Temporal Logic for Visibly Pushdown Systems
Authors: Bozzelli Laura , Montanari Angelo , Peron Adriano 
Published: February 2023

In this article, we introduce and investigate an extension of Halpern and Shoham’s interval temporal logic
HS
for the specification and verification of branching-time context-free requirements of pushdown systems under a state-based semantics over Kripke structures enforcing visibility of the pushdown operations. The proposed logic, called nested
BHS
, supports branching-time both in the past and in the future and is able to express non-regular properties of linear and branching behaviours of procedural contexts in a natural way. It strictly subsumes well-known linear time context-free extensions of
LTL
such as
CaRet
[
4
] and
NWTL
[
2
]. The main result is the decidability of the visibly pushdown model-checking problem against nested
BHS
. The proof exploits a non-trivial automata-theoretic construction.
Catastrophe by Design in Population Games: A Mechanism to Destabilize Inefficient Locked-in Technologies
Authors: Leonardos Stefanos , Sakos Joseph , Courcoubetis Costas , Piliouras Georgios 
Published: February 2023

In multi-agent environments in which coordination is desirable, the history of play often causes lock-in at sub-optimal outcomes. Notoriously, technologies with significant environmental footprint or high social cost persist despite the successful development of more environmentally friendly and/or socially efficient alternatives. The displacement of the status quo is hindered by entrenched economic interests and network effects. To exacerbate matters, the standard mechanism design approaches based on centralized authorities with the capacity to use preferential subsidies to effectively dictate system outcomes are not always applicable to modern decentralized economies. What other types of mechanisms are feasible?
In this article, we develop and analyze a mechanism that induces transitions from inefficient lock-ins to superior alternatives. This mechanism does not exogenously favor one option over another; instead, the phase transition emerges endogenously via a standard evolutionary learning model, Q-learning, where agents trade off exploration and exploitation. Exerting the same transient influence to both the efficient and inefficient technologies encourages exploration and results in irreversible phase transitions and permanent stabilization of the efficient one. On a technical level, our work is based on bifurcation and catastrophe theory, a branch of mathematics that deals with changes in the number and stability properties of equilibria. Critically, our analysis is shown to be structurally robust to significant and even adversarially chosen perturbations to the parameters of both our game and our behavioral model.