bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk and protective factors for resilience among adolescents and young adults with beta-thalassemia major
Authors: Rambod Masoume , Hamidizadeh Saeed , Bazrafshan Mohammad-Rafi , Parviniannasab Ali Mohammad 
Published: August 2023

AbstractBackgroundResilience is the ability to overcome adversity in response to a potentially traumatic event. It can relieve people’s discomfort and build personal capacity when facing a stressful situation such as beta thalassemia major. Resilience is a complex and multidimensional concept and is influenced by protective and risk factors. Therefore, the aims of the present study were to (1) investigate the relationship between protective (social support and hope) and risk (uncertainty and defensive coping) factors with resilience and (2) examine the mediating role of courageous coping between these protective and risk factors in resilience.MethodsThis descriptive-analytical study was performed on 312 adolescents and young adults with beta-thalassemia major aged 12–24 years; they were selected using purposeful sampling from two different outpatient thalassemia clinics in the south of Iran. Data were collected in a face-to-face survey using Zimmet Multidimensional Scale of Perceived Social Support, Herth Hope, Stewart Uncertainty in Illness scale, Jalowiec Coping, and Connor–Davidson resilience Scale from April 2022 to November 2022. The collected data were analyzed using descriptive tests, Pearson correlation, and a structural equation model.ResultsAccording to the main findings of mediation analysis, courageous coping partially mediated the relationship between social support and resilience [(β = 0.042; 95% BC CI (0.003, 0.131)] and fully mediated the relationship between hope and resilience [(β = 0.166; 95% BC CI (0.031, 0.348)]. In other cases, uncertainty and defensive coping had a direct and indirect effect on resilience, respectively.ConclusionBased on these results, health professionals and healthcare policymakers should consider this mediator in developing programs to improve resilience. Also, the use of courageous coping could modulate the effect of defensive coping on resilience. Therefore, teaching the use of courageous coping can play an important role in improving resilience.
The effect of childhood trauma and resilience on psychopathology in adulthood: Does bullying moderate the associations?
Authors: Švecová Júlia , Furstova Jana , Kaščáková Natália , Hašto Jozef , Tavel Peter 
Published: August 2023

Abstract
Background
Exposure to traumatic events in childhood, including bullying, can negatively affect physical and mental health in adulthood. The aim of the present study was to determine the prevalence of bullying in different sociodemographic groups of the Slovak Republic and to assess the moderating effect of bullying on the associations between childhood trauma, resilience, and the later occurrence of psychopathology.

Methods
For the analyses, a representative sample of the population of the Slovak Republic was used (N = 1018, mean age 46.24 years, 48.7% of men). Multivariate linear regression models were used to investigate the predictive ability of childhood trauma (The Childhood Trauma Questionnaire, CTQ) and resilience (The Brief Resilience Scale, BRS) to explain psychopathology (The Brief Symptom Inventory, BSI-53). Bullying (The Adverse Childhood Experiences – International Questionnaire, ACE-IQ) was used as a moderator.

Results
In total, 13.5% of respondents have experienced bullying. The most common form of bullying was making fun of someone because of how their body or face looked (46.7%) and excluding someone from activities or ignoring them (36.5%). Higher scores in all types of psychopathology and the Global Severity Index (GSI) were significantly associated with higher scores of emotional and sexual abuse, and some of them with physical neglect. The protective effect of resilience was moderated by bullying in several types of psychopathology, specifically in somatization, obsessive-compulsive, interpersonal sensitivity, depression, psychoticism, and the GSI.

Conclusion
Understanding the links between childhood trauma, bullying, and later psychopathology can help professionals target policies, resources, and interventions to support children and families at risk. Every child should feel accepted and safe at home and school.
A novel ELOVL4 variant, L168S, causes early childhood-onset Spinocerebellar ataxia-34 and retinal dysfunction: a case report
Authors: Gyening Yeboah Kofi , Boris Keren , Cyril Mignot , Brush Richard S. , Nassogne Marie-Cécile , Agbaga Martin-Paul 
Published: August 2023

AbstractSpinocerebellar ataxia 34 (SCA34) is an autosomal dominant inherited disease characterized by age-related cerebellar degeneration and ataxia caused by mutations in the Elongation of Very Long Chain Fatty Acid-4 (ELOVL4) gene. The ELOVL4 enzyme catalyzes the biosynthesis of both very long chain saturated fatty acids (VLC-SFA) and very long chain polyunsaturated fatty acids (VLC-PUFA) that are important for neuronal, reproductive, and skin function. Several variants in ELOVL4 have been shown to cause different tissue-specific disorders including SCA34 with or without Erythrokeratodermia Variabilis (EKV), a skin condition characterized by dry, scaly skin, Autosomal Dominant Stargardt-Like Macular Dystrophy (STGD3), and seizures associated with neuro-ichthyotic disorders. What is puzzling is how different mutations in the same gene seem to cause different tissue-specific disorders. To date, no SCA34 patients have presented with both SCA34 and STGD3 pathology that is caused by ELOVL4 variants that cause truncation of ELOVL4. Here, we report a novel case of an early childhood onset and rapidly progressive cerebellar degeneration and retinal dysfunction in a Belgian-Italian girl who developed severe dysarthria and gait problems starting at about 3.5 years of age and progressed to immobility by 4.5 years of age. Brain magnetic resonance imaging (MRI) revealed progressive vermian, cerebellar, cortical atrophy, progressive corpus callosum slimming, and hot cross bun sign visible on the MRI. Ophthalmological examinations also revealed progressive macular dysfunction as measured by electroretinography. Using exome sequencing, we identified a novel heterozygous ELOVL4 variant, c.503 T > C (p. L168S) in the patient. To understand the enzymatic function of this novel ELOVL4 variant and how it alters the levels of VLC-PUFA and VLC-SFA biosynthesis to contribute to cerebellar and retinal dysfunction, we expressed wild-type ELOVL4 or the L168S ELOVL4 variant in cell culture and supplemented the cultures with VLC-PUFA or VLC-SFA precursors. We showed that the L168S ELOVL4 variant is deficient in the biosynthesis of VLC-SFA and VLC-PUFA. Our work suggests that differential depletion of these fatty acids may be a contributing factor to the pathogenic mechanism of SCA34 with or without EKV. Further studies will help further define how the different ELOVL4 variants cause different tissue-specific disorders with variable ages of onset.
16S metabarcoding, total soil DNA content, and functional bacterial genes quantification to characterize soils under long-term organic and conventional farming systems
Authors: Maretto Laura , Deb Saptarathi , Ravi Samathmika , Della Lucia Maria Cristina , Borella Matteo , Campagna Giovanni , Squartini Andrea , Concheri Giuseppe , Nardi Serenella , Stevanato Piergiorgio 
Published: August 2023

Abstract
Background
The threatening impact of conventional agriculture (CA) on soils could be due to the detrimental effects on soil microbial communities. Conversely, organic agriculture (OA) is envisaged as potentially enhancing helpful microbial communities and is proposed as environmentally sustainable. The soil microbiome influences soil health and quality, hence, it requires deeper investigation and understanding. In this study, applying 16S metabarcoding and qPCR techniques, we compared the microbial patterns of long-term organically and conventionally managed soils to explore their similarities and differences.

Results
Total DNA quantification showed an over 20-fold higher amount of DNA in OA soils (mean = 22.1 ± 3.92 μg g−1), compared to CA soils (mean = 0.95 ± 0.17 μg g−1). While 16S metabarcoding evidenced the absence of significant differences among communities of the two farming systems in terms of ecological indices, the qPCR analyses targeting functional genes reported a significantly higher abundance of all considered targets in OA sites spanning up to four-fold log increases. While OA and CA did not appear to affect overall bacterial diversity or evenness per se, qPCR-based functional analysis in OA showed a consistently higher abundance of all the salient microbial genes tested, when compared to CA, underlying a potentially beneficial impact on soil fertility and sustainability.

Conclusions
In essence, the sequencing-based analysis of absolute bacterial diversity could not differentiate the farming systems based on the amount of diversity but identified a unique set of taxa defining each. Hence, pairing this evaluation with the qPCR-based functional gene analyses can be a suitable approach to distinguish the exerted effects of CA or OA on soils.

Graphical Abstract
Organosolv pretreatment: an in-depth purview of mechanics of the system
Authors: Nair Lakshana G. , Agrawal Komal , Verma Pradeep 
Published: August 2023

AbstractThe concept of biorefinery has been advancing globally and organosolv pretreatment strategy has seen an upsurge in research due to its efficiency in removing the recalcitrant lignin and dissolution of cellulose. The high-performance organosolv system uses green solvents and its reusability contributes concurrently to the biorefinery sector and sustainability. The major advantage of the current system involves the continuous removal of lignin to enhance cellulose accessibility, thereby easing the later biorefinery steps, which were immensely restricted due to the recalcitrant lignin. The current system process can be further explored and enhanced via the amalgamation of new technologies, which is still a work in progress. Thus, the current review summarizes organosolv pretreatment and the range of solvents used, along with a detailed mechanistic approach that results in efficient pretreatment of LCB. The latest developments for designing high-performance pretreatment systems, their pitfalls, and advanced assessments such as Life Cycle Assessment along with Techno-Economic Assessment have also been deliberated to allow an insight into its diverse potential applicability towards a sustainable future.
Graphical Abstract
FPGA design and implementation for adaptive digital chaotic key generator
Authors: Elsayed Ghada , Soleit Elsayed , Kayed Somaya 
Published: August 2023

Abstract
Background
Information security is very important in today’s digital world, especially cybersecurity. The most common requirement in securing data in all services: confidentiality, digital signature, authentication, and data integrity is generating random keys. These random keys should be tested for randomness. Hardware security is more recommended than software. Hardware security has more speed and less exposure to many attacks than software security. Software security is vulnerable to attacks like buffer overflow attacks, side-channel attacks, and Meltdown–Spectre attacks.

Results
In this paper, we propose an FPGA Implementation for the adaptive digital chaotic generator. This algorithm is proposed and tested before. We introduce its implementation as hardware. This algorithm needs a random number seed as input. We propose two designs. The first one has an input random number. The second one has PRNG inside. The target FPGA is Xilinx Spartan 6 xc6slx9-2-cpg196. We used MATLAB HDL Coder for the design. We propose a configurable Key block’s length. For 32 bit the maximum frequency is 15.711 MHz versus 11.635 MHz for the first and second designs respectively. The area utilization of the Number of Slice Registers is 1% versus 2%. The number of Slice Look Up Tables is 40% versus 59%. number of bonded input output blocks is 64% versus 66%. otherwise are the same for the two designs.

Conclusions
In this paper, we propose an efficient and configurable FPGA Design for adaptive digital chaotic key generator. Our design has another advantage of storing the output keys internally and reading them later.
Microbiological analysis of nosocomial pneumonia at Tanta University Chest Hospital
Authors: Elkholy Amira Abdelgalil , Hantera Mohamed Sayed , Abd El-Zaher Ayman Hassan , Mwafy Mai M. , Tourky Amira Samy , Abo Elnoor Mostafa Tarek , Torky Mohamed 
Published: August 2023

Abstract
Background
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) represent a major health problem among hospitalized patients leading to consequent morbidity and mortality specially after Covid-19 era and spread of multidrug-resistance organisms)MDRO) in hospitals.

Aim
This study aimed to analyze the commonest microorganisms responsible for HAP and VAP at Tanta University Chest Hospital.

Methods
This prospective observational study was done at Chest Department, Faculty of Medicine, started from June 2022 to February 2023. Fifty HAP patients’ sputum samples and 50 VAP patients (25 endotracheal aspirates and 25 bronchoalveolar lavages) were included. All collected samples were submitted to standard microbiological tests at Microbiology Department, Tanta Faculty of Medicine.

Results
A total number of 50 HAP and 50 VAP cases were included. Microbial isolates were relatively the same in both groups, where Klebsiella pneumoniae was the predominant isolates (56) followed by Staphylococcus aureus (25), Escherichia coli (14), Pseudomonas aeruginosa (13), Acinetobacter baumannii (5), Streptococcus pneumoniae (4), Enterococci (3), Stenotrophomonas maltophilia (2), Citrobacter freundii (2), Streptococcus pyogenes (2), Providencia stuartii (1), and 7 isolates of Candida. Antimicrobial susceptibility showed predominance of drug-resistance organisms in VAP (78%) versus HAP (28%), P-value: < 0.001. Klebsiella pneumonia showed higher rates of resistance (37 out of 56 isolates, P-value = 0.020). Four out of 5 Acinetobacter baumannii isolates were multidrug resistant, and 2 isolates of Stenotrophomonas maltophilia were polydrug resistant. Multivariate logistic regression analysis showed that intravenous antibiotic administration within last 3 months was associated with risk for MDR-HAP, while univariate regression analysis showed that intravenous antibiotic administration within the last 3 months was the strongest predictor for MDR-VAP. A higher mortality rate was recorded in VAP group (66%), versus (14%) in HAP group (P-value: < 0.001).

Conclusion
Microbial isolates were relatively the same in both HAP and VAP, but VAP showed significant predominance of drug-resistant organisms. The most significant predictor for risk of MDRO infection in HAP and VAP was intravenous antibiotic administration within last 3 months; so, raising attention towards antibiotic choice may improve the outcome. Finally, VAP was associated with higher mortality compared to HAP.
Thermal management strategy for active regeneration of diesel particulate filter
Authors: Guo Shenggang , Zhang Yu , Zhang Xiaoxue , Man Hengxiao , Liu Hao 
Published: August 2023

AbstractThe method of diesel oxidation catalyst (DOC) assistance is an effective way to achieve active regeneration of diesel particulate filter (DPF). Therefore, an appropriate DOC inlet temperature is the essential boundary condition for this regeneration process. In this paper, the thermal management measures and a novel strategy based on the requirements of DPF active regeneration have been proposed and studied through experiments. Results show that intake throttling can increase DOC inlet temperature by 45% at high speed and 13% at low speed. However, its effect becomes significant only after the throttle closure exceeds 65%. Near post-injection is a more effective method than intake throttling to increase the DOC inlet temperature, and is suitable for situations where the DOC inlet temperature differs greatly from the target value. Under the premise of economic consideration, the optimal value of near post-injection time is always 20°CA after top dead center (TDC). The near post-injection quantity has a greater effect on DOC inlet temperature than the near post-injection time. However, too large near post-injection quantity can also lead to a sharp deterioration in fuel economy. Meanwhile, a novel thermal management strategy based on engine working zone division is proposed according to the ability of different thermal management measures and the distribution law of original DOC inlet temperature. With this strategy, the DOC inlet temperature in whole engine operating range increases significantly. In steady state, more than 80% of the operating points can reach the target value of 450 ℃. In world harmonized transient cycle (WHTC), the average DOC inlet temperature is also increased by 28.8%.
Endovascular repair for arterio-venous fistula treatment: a case report
Authors: Hayashi Jun , Sekine Yuki , Toyama Shuji , Uchida Tetsuro , Watanabe Tetsuo 
Published: August 2023

Abstract
Background
Arterio-venous fistula is a rare clinical entity that occurs as a result of a ruptured abdominal aortic aneurysm into the inferior vena cava or iliac vein. Open surgery has been considered the treatment of choice for this condition; however, endovascular repair has become an evolving therapeutic option over the past 20 years. The endovascular treatment has contributed to a decrease in the perioperative mortality; nevertheless, some endovascular repair specific concern for residual fistula still remains.

Case presentation
A 70-year-old man was referred to our department for an enlarged inferior vena cava without any complaint. Contrast-enhanced computed tomography demonstrated a 40-mm AAA and a 42-mm right saccular CIAA, with a fistula between the CIAA and left CIV. Endovascular aneurysm repair which focused on the exclusion of the right CIAA and prevention of endoleak formation was performed. To prevent type 2 endoleaks, which cause residual arterio-venous shunt flow, right internal iliac artery was embolized with a vascular plug prior to stent graft procedure. Successful aneurysm exclusion without residual arterio-venous shunt flow was confirmed with a final angiographic examination. The patient had an uneventful recovery, and computed tomography 1 month later showed no sign of persistent fistula.

Conclusions
Although endovascular treatment for AVF has a negative possibility of residual shunt, stent graft with a focus on type 2 endoleak prevention can be an attractive treatment option, reducing the incidence of residual AVF.
Quantum phase transition in CeCoIn5: Experimental facts and theory
Authors: Shaginyan V. R. , Msezane A. Z. , Zverev M. V. , Leevik Y. S. 
Published: August 2023

Abstract
The condensed-matter community is involved in a hot debate on the nature of quantum critical points (QCP) governing the low-temperature properties of heavy fermion metals. The smeared jump-like behavior revealed both in the residual resistivity

and the Hall resistivity R

H
, along with the violation of the time invariance symmetry

and the charge invariance

, include the violation of quasiparticle-hole symmetry, and provide vital clues on the origin of both the non-Fermi-liquid behavior and QCP. For the first time, based on a number of important experimental data, we show that these experimental observations point out unambiguously that QCP of

is accompanied by the symmetry violation, and QCP itself is represented by the topological fermion-condensation quantum phase transition (FCQPT) connecting two Fermi surfaces of different topological charges.
Higher Risk of Incident Hyperthyroidism in Patients With Atrial Fibrillation
Authors: Huang Pang-Shuo , Cheng Jen-Fang , Chen Jien-Jiun , Wang Yi-Chih , Hwang Juey-Jen , Wu Cho-Kai , Tsai Chia-Ti 
Published: August 2023

Abstract

Background
Atrial fibrillation (AF) has been linked to increased hyperthyroidism risk, but contributing factors are unclear.

Objective
We aimed to investigate whether AF could predict hyperthyroidism and related risk factors.

Methods
This retrospective cohort study was conducted in a tertiary medical institution and included patients aged 18 years or older with AF but without hyperthyroidism at diagnosis. The endpoint was defined as newly diagnosed hyperthyroidism during the follow-up period.

Results
The study cohort included 8552 participants. Patients who developed new hyperthyroidism were younger and the proportion of females was higher. They had fewer comorbidities, including diabetes (26% vs 29%, P = .121), hypertension (51% vs 58%, P &lt; .001), coronary artery disease (17% vs 25%, P &lt; .001), stroke (16% vs 22%, P &lt; .001), and end-stage renal disease (ESRD) (6% vs 10%, P = .001). The CHADS2 score was lower in patients with hyperthyroidism (1.74 vs 2.05, P = .031), but there was no statistically significant difference in the CHA2DS2-VASc and HAS-BLED score. Cox regression analysis identified younger age, female gender, history of congestive heart failure, hypertension, diabetes, non-ESRD status, and lower CHADS2 score but not CHA2DS2-VASc as independent predictors of incident hyperthyroidism during follow-up. We also propose a novel, simple risk stratification score (SAD HEC2 score) with excellent predictive power for incident hyperthyroidism during follow-up.

Conclusion
Our results provide insight into clinical risk factors for the development of hyperthyroidism in AF patients, as identified by the novel SAD HEC2 score. AF appears to be a common precursor of hyperthyroidism.
Global Currents and the Transformation of Space in Indian Ocean Africa
Authors: Prestholdt Jeremy 
Published: August 2023

AbstractThe Indian Ocean region is a continuum of social, economic, and cultural engagements. It is also a remarkably elastic matrix of human relations that has profoundly influenced and been influenced by global engagements. These interregional engagements raise questions of how to frame global circularities within Indian Ocean pasts. How have imbrications with other world regions affected the networks and boundaries of the Indian Ocean region? And how have Indian Ocean societies affected the wider world? To answer these questions this article traces Indian Ocean histories within global contexts between the sixteenth and early twentieth centuries. It offers a stereoscopic history of Indian Ocean Africa that appreciates Indian Ocean linkages alongside the region's global entanglements, which in turn demonstrates how Africa's Indian Ocean rim has affected and been affected by wider global relationships. The article suggests that imbrications of regional and extraregional networks do not negate the Indian Ocean's coherence or the central importance of regional linkages. Rather, it argues that such imbrications prompt alternative ways of perceiving Indian Ocean worlds: namely, as layered matrices shaped by the dual articulation of Indian Ocean rim societies.