bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functioning of a canopy-dominated intertidal community during emersion: highly productive but heterotrophic at the annual scale.
Authors: Golléty Claire , Yearsley Jon , Migné Aline , Davoult Dominique 
Published: July 2023

Abstract
In order to address lack of data regarding coastal carbon budgets, we estimated the annual metabolic carbon budget of an intertidal rocky reef macroalgal community during emersion. This budget is based on direct in situ measurements during emersion and establishes the seasonal variations of the photosynthetic parameters of such a community. CO2 fluxes were measured hourly to study the response of community gross primary productivity (GPP) to irradiance and the variation of GPP and community respiration (CR) over the emersion period at different times of the year. These were combined together with existing monthly measures of GPP and CR hourly rates to model the variations of these fluxes as a function of irradiance and the tidal cycle throughout an entire calendar year. Daily, monthly and annual values of GPP, CR and net primary productivity (NPP) were calculated with a relatively low sensitivity to any of the parameters used. While GPP fluxes show comparable orders of magnitude to those measured in other systems, higher CR fluxes lead to a heterotrophic system during emersion, both under measured (NPP = -299 gC m-2 yr-1) and theoretical irradiances (NPP = -119 gC m-2 yr-1). This heterotrophy is directly linked to the light availability, varying according to combined daily, tidal and seasonal cycles, and to temperature at the seasonal scale. Measurements performed in situ at the community scale integrated interactions that are otherwise absent at the individual scale. This gives access to aspects of the functioning that cannot be otherwise identified.
Ibulocydine inhibits migration and invasion of TNBC cells via MMP-9 regulation
Authors: Kwon Mi Ri , Park Ji Soo , Ko Eun Jung , Park Jin , Ju Eun Jin , Shin Seol Hwa , Son Ga Won , Lee Hye Won , Park Hee Hyun , Park Yun-Yong , Kang Myoung-Hee , Kim Yeon Joo , Kim Byeong Moon , Lee Hee Jin , Song Si Yeol , Park Seok Soon , Jeong Seong-Yun , Choi Eun Kyung 
Published: July 2023

Abstract
Background
Triple-negative breast cancer (TNBC) accounts for approximately 15–20% of all breast cancer types, indicating poor survival prognosis with more aggressive biology of rapidly progressive growth, metastasis to the lung, and short response duration to available therapies. TNBC is characterized by the negative expression of three hormone receptors. Therefore, compared to other breast cancers, TNBC is difficult to treat using hormone inhibitors and is resistant to chemotherapy. Additionally, the lack of effective targets limits the development of therapeutics. Ibulocydine (IB) is a novel (cyclin-dependent kinase) CDK7/9 inhibitor prodrug displaying potent anti-cancer effects against various cancer cell types. We performed the following experiments to determine whether IB inhibits metastasis and eventually overcomes the poor drug response in TNBC.
Methods
Colony-forming, cell counting kit-8 (CCK-8), wound healing, trans-well assays, and western blotting were performed in vitro. An experimental metastasis model was developed via intravenous injection of MDA-MB-231-Luc cells in vivo, and tumor growth was monitored using an In Vivo Imaging System (IVIS) spectrum.
Results
The result showed that IB reduced the viability of various TNBC cell lines in a dose-dependent manner. Pretreatment with z-VAD effectively blocked IB-induced cell death and cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in TNBC cells. A reduction in the migration and invasion abilities of TNBC cell lines was observed following IB treatment in migration and invasion assays. We determined the expression levels of metastasis-related markers using western blotting and found that the expression of matrix metalloproteinase-9 (MMP-9) decreased in an IB dose-dependent manner. In addition, IB-induced inhibition of migration and invasion was blocked in MMP9-overexpressing MDA-MB-231-Luc cells. Results of in vivo experiments using the metastasis model showed that metastasis of MDA-MB-231-Luc cells to the lung was inhibited by IB.
Conclusions
Collectively, these results showed that IB inhibited the growth of TNBC cells by inducing caspase-mediated apoptosis and blocking metastasis by reducing MMP-9 expression, suggesting a novel therapeutic agent for metastatic TNBC.
Numerical Simulation of the Indian Monsoon Climate using the WRF Regional Climate Model
Authors: MadhuSai Singuru , Panda Roshmitha , Sivaramakrishna Surireddi Satya Venkata 
Published: July 2023

Abstract

Climate studies are essential in understanding the Earth's climate system and its dynamics. Numerical models play a significant role in these studies by simulating the behaviour of the atmosphere and providing insights into future climate scenarios. In the recent years, the Weather Research and Forecasting (WRF) model has emerged as a widely used tool for studying climate on regional scales. In the present study, we simulated the mean features of the Indian summer monsoon (June through September) climate using the WRF regional climate model. The WRF model with a horizontal resolution of 25 km is driven by the Community Climate System Model version4 (CCSM4) for the period 2006-2021 which is a part of the fifth generation of Coupled Model Inter comparison Project (CMIP5) using the Representative Concentration Pathway 6.0 (RCP6.0) over the South Asia Coordinated Regional Downscaling Experiment (SA-CORDEX) domain. The model is simulated on a continuous mode throughout its annual cycle for the period of integration. But for the presentation of results, the summer monsoon months of JJAS for the period 2007 to 2021 are only analysed. The performance of the model was assessed through the study of the spatial distribution of Air temperature (2m), Winds, Pressure, Rainfall, and the Vertical Integrated Moisture flux convergence (VIMFC). The simulated parameters were compared to those in ERA5 reanalysis and the India Meteorological Department (IMD) gridded rainfall. The performance of the WRF model was evaluated for simulating the regional scale precipitation over 5 homogenous rainfall zones of India. The WRF model accurately reproduces the Tropospheric Temperature Gradient (TTG) between the southern and northern regions. The sub-regional scale analysis of the simulated 2m temperature and precipitation for 30 meteorological subdivisions of India reveals that the WRF model performs better than the CCSM4 model. Results indicate that the model is able to capture the mean climatological features of the monsoon viz. monsoon onset, low-level Jet and the upper-level tropical easterly jet.
Comparison of the efficacy and safety of icotinib monotherapy and combined therapy of icotinib and vinorelbine as first-line treatment for advanced lung adenocarcinoma in patients with sensitive EGFR mutations: A retrospective study
Authors: zhang Jing , Hu Huihua , Yu Jian , Lin Dong , Xu Haipeng 
Published: July 2023

Abstract
This investigation compares the safety and therapeutic efficiency of icotinib monotherapy and icotinib + vinorelbine combination therapy against non-small cell lung cancer (NSCLC) with EGFR gene mutation.
Methods: Data was acquired from105 patients who enrolled in the Fujian Medical University Cancer Hospital between October 2018 and December 2021, including individuals with NSCLC-EGFR mutations who underwent first-line icotinib therapy with or without vinorelbine. Of these 105 cases, 75 patients received icotinib monotherapy (IM), and 35 received icotinib + vinorelbine combination therapy (I+V) and were grouped accordingly. Progression-free survival (PFS) and adverse effects were compared in the two cohorts. Furthermore, the mechanism of drug resistance in the combinational therapy group was also determined.
Results: PFS was notably prolonged in the I+V group (12 months vs. 9.3 months, HR=0.501, 95%CI 0.34-0.75, P<0.01). The mechanism of drug resistance was not affected by I+V therapy. Both the disease control and objective response rates in the I+V group were comparable to the IM group. Moreover, increased gastrointestinal reactions were observed in the I+V group thanin the IM group.
Conclusions: This study provides information about the effects of combined icotinib and vinorelbine therapy as a first-line strategy for advanced NSCLC patients with EGFR mutations. However, further verification via a prospective phase 3 clinical trialis required.
Construction of a multi-tissue cell atlas reveals cell-type-specific regulation of molecular and complex phenotypes in pigs
Authors: Yi Guoqiang , Chen Lijuan , Li Houcheng , Teng Jinyan , Wang Zhen , Qu Xiaolu , Chen Zhe , Cai Xiaodian , Zeng Haonan , Bai Zhonghao , Li Jinghui , Pan Xiangcun , Yan Leyan , Wang Fei , Lin Lin , Luo Yonglun , Sahana Goutam , Lund Mogens , Ballester Maria , Crespo-Piazuelo Daniel , Karlskov-Mortensen Peter , Fredholm Merete , Clop Alex , Amills Marcel , Loving Crystal , Tuggle Christopher , Madsen Ole , Li Jiaqi , Zhang Zhe , Liu George , Jiang Jicai , Fang Lingzhao 
Published: July 2023

Abstract
The systematic characterization of cellular heterogeneity among tissues and cell-type-specific regulation underlying complex phenotypes remains elusive in pigs. Within the Pig Genotype-Tissue Expression (PigGTEx) project, we present a single-cell transcriptome atlas of adult pigs encompassing 229,268 high-quality nuclei from 19 tissues, annotated to 67 major cell types. Besides cellular heterogeneity within and across tissues, we further characterize prominent tissue-specific features and functions of muscle, epithelial, and immune cells. Through deconvoluting 3,921 bulk RNA-seq samples from 17 matching tissues, we dissect thousands of genetic variants with cell-type interaction effects on gene expression (ieQTL). By colocalizing these ieQTL with variants associated with 268 complex traits, we provide new insights into the cellular mechanisms behind these traits. Moreover, we highlight that orthologous genes with cell-type-specific regulation in pigs exhibit significant heritability enrichment for some human complex phenotypes. Altogether, our work provides a valuable resource and highlights novel insights in cellular regulation of complex traits for accelerating pig precision breeding and human biomedical research.
Hepatitis C survey among the prison community in the Triângulo Mineiro region, Minas Gerais, Brazil: revealing an invisible population.
Authors: Gomide Geisa Perez Medina , Teixeira Mariana dos Santos , Pereira Guilherme Andrade , Camargo Fernanda Carolina , Pastori Beatriz Guerta , Dias Felipe Ferreira , Ferreira Júlio Cesar do Carmo , Silva Nathan Castro , Neta Otilia Silva de Carvalho , Meireles Pedro Teixeira , de Lima Vanessa Guizolfe Sales , Cunha Rejane Andrea de Paulo , Abdalla Douglas Reis , de Oliveira Cristina da Cunha Hueb Barata 
Published: July 2023

Abstract

Background
Hepatitis C is a health problem in penitentiaries and its elimination must be strengthened. The study describes socio-epidemiological aspects of a hepatitis C investigation in a penitentiary in the region of Triângulo Mineiro in Minas Gerais, Brazil.
Methods
It is a cross-sectional and epidemiological survey, with an exploratory, observational, quantitative element. It was carried out in a state penitentiary with 1564 inmates. A semi-structured individual interview and anti-HCV testing were carried out between December 2019 and March 2020, in a simple random sample of 240 prisoners.
Results
The prevalence for HCV was 2.1% (anti-HCV test). Most participants were men (76.6%), with a mean age of 33.8 years, with incomplete high school educational level (80.5%). 93.8% self-reported heterosexuality, multiple sexual partners (mean of 6.5 partners/year) and inconsistent condom use. 54.2% had undergone a previous surgical procedure. Regarding alcohol use, 72.9% reported some consumption, at an average amount of 188.5 grams/day. Non-injecting drug use was reported by 70% of participants and cigarette by 56.3%. Other aspects were the recurrence of imprisonment (70.4%) and having the tattoos (75.8%).
Conclusion
The study supports the organization of epidemiological survey protocols, the construction of intersectoral health projects and the description of the prison population's vulnerabilities.
Influence of isotretinoin on orthodontic tooth movement in rats: microtomographic and histomorphometric analysis
Authors: Ferreira Mayra Fernanda , Silva Cristina Antoniali , Ervolino Edilson , Costa Luy de Abreu , Santos José Ricardo Prando dos , Delbem Alberto Carlos Botazzo , de Mendonça Marcos Rogério 
Published: July 2023

Abstract

Objective
Isotretinoin, also known as 13-cis-retinoic acid, is an isomer of tretinoin, the oxidized form of Vitamin A. Orthodontic tooth movement (OTM) is the result of a cascade of inflammatory responses stimulated by a physical element that is the force generated by orthodontic appliances. Isotretinoin is mainly used among adolescents and young adults, and coincidentally it is this age group that also undergoes orthodontic treatment.
Materials and Methods
Thirty-five animals were used, and they were randomly divided into 7 groups, containing 5 animals in each group. Group 1: Control; Group 2: OTM for 7 days; Group 3: OTM for 14 days; Group 4: Treated with isotretinoin for 14 days; Group 5: Treated with isotretinoin for 21 days; Group 6: Treated with isotretinoin for 14 days and undergoing OTM for 7 days; Group 7: Treated with isotretinoin for 21 days and undergoing OTM for 14 days. In Groups 6 and 7, the animals were treated with isotretinoin at a dosage of 1.0mg/kg/day for 7 days before OTM and maintained during the movement period in the respective groups.
Results
There was no significant difference on microtomographic parameters [Trabecular Volume (BV/TV), Trabecular Thickness (Tb.Th), Number of Trabeculae (Tb.N) and Trabecular Separation (Tb.Sp)] and tooth displacement between groups.
Conclusion
Isotretinoin did not cause a reduction in tooth displacement during OTM when administered at a dose of 1.0mg/kg/day and isotretinoin did not change the microtomographic parameters of animals treated with isotretinoin + OTM.
Association between sFer Levels in Early Pregnancy and Thyroid Function in Chinese Population
Authors: Li Xing , Zhang Zhuyuan , Cai Wen , Zhou Xuexin , Zhang Yan , Wu Cailiang , Xu Xianming , Wu Hao 
Published: July 2023

Abstract
Backgrounds:
The relationship of Iron deficiency and thyroid hormone have been researched a lot among pregnant or other healthy population. However, invisible iron deficiency, namely shortage of sFer level, has been barely investigated among Chinese pregnant women. This study aimed to explore the effects of sFer status on thyroid function in a population-based upper first-class hospital.
Methods
A total of 781 singleton pregnant women of gestation in Shanghai General Hospital took part in this retrospective cohort study. The participants were divided into four groups by quartiles of serum ferritin levels (Q1–4). Binary logistic regressions were used to examine the strength of association between the different traits and the serum ferrin (sFer) quartiles separately, where Q1 (lowest ferritin quartile) was taken as the base reference. One-way ANOVA was adopted to compare the averages of the different variables across Sfer quartiles. Categorical measures were compared by Fisher exact test or chi-square test.
Results
As the sFer concentration rises, incidence of premature birth (15.8%vs 12.3% vs 9.20% vs 6.20% p = 0.016) as well as threatened miscarriage (14.8% vs 7.2% vs 8.70% vs 6.70% p = 0.021)presented a downward trend. Compared with the other sFer group, subjects of the low sFer group were older, were more often found to have lower serum γT3 and FT4 levels in early pregnancy but not in middle pregnancy.
Conclusions
The correction of invisible iron deficiency with inadequate sFer status prior to pregnancy or during early pregnancy is imperative, not only to prevent anemia, but also for maintaining optimum thyroid function and normal fetal development. For clinicians, sFer status of pregnant women should be attached great importance apart from attention to iron level.
North cotton growing zone of India witnessed another whitefly outbreak within a decade
Authors: Kumar Rishi , Sain S. K. , Singh Satnam , Pandher Suneet , Singh Roop , Jakhar Anil , Kaur Jasjinder , Paul Debashis , Prakash A. H. , Prasad Y. G. 
Published: July 2023

Abstract

Whitefly, Bemisia tabaci (Gennadius), is a polyphagous and important pest of cotton worldwide. Both adults and nymphs of B. tabaci affect the crop by causing direct and indirect damage. A severe outbreak of whitefly was experienced during 2015 in North India on cotton followed by the outbreak during 2022 cotton season. During 2015, whitefly crossed and persisted above ETL (Economic Threshold Level is 18adults/ 3 leaves) between 28th - 35th SMW but during 2022 stayed above ETL between 27th - 36th SMW and peak incidence noticed during 31st and 29th SMW , respectively. So in 2022, early pest buid up in the form of ETL as well as peak activity indicating longer persistence (≥10 weeks ) of whitefly and high severity in terms of average whitefly population during season resulted in more damage to cotton crop. Additionally , farmers’ field survey data during 2022, showed whitefly population crossed ETL at 585 out of 1317 locations (44.42 percent) and during 2015, 620 out of 1089 locations (57 per cent ) were recorded above ETL indicating that unlike 2015; 2022 outbreak was not uniform in the entire zone wherein only few blocks of Punjab, Haryana and Rajasthan recorded severe infestations of whitefly.
IKGM: A novel method for identifying key genes in macroevolution based on deep learning with attention mechanism
Authors: Mao Jiawei , Cao Yong , Zhang Yan , Huang Biaosheng , Zhao Youjie 
Published: July 2023

Abstract

Macroevolution of most organisms is generally the result of synergistic action of multiple key genes in evolutionary biology. Unfortunately, the weights of these key genes in macroevolution are difficult to assess. In this study, we designed various word embedding libraries of natural language processing (NLP) considering the multiple mechanisms of evolutionary genomics. A novel method (IKGM) based on three types of attention mechanisms (domain attention, kmer attention and fused attention) were proposed to calculate the weights of different genes in macroevolution. Taking 34 species of diurnal butterflies and nocturnal moths in Lepidoptera as an example, we identified a few of key genes with high weights, which annotated to the functions of circadian rhythms, sensory organs, as well as behavioral habits etc. This study not only provides a novel method to identify the key genes of macroevolution at the genomic level, but also helps us to understand the microevolution mechanisms of diurnal butterflies and nocturnal moths in Lepidoptera.
Infrared study of semimetal LaSb: coexistence of ultrahigh- and moderate-mobility carriers
Authors: Kim HyunDon , Yu Kwangnam , Kim Jiho , Shon Wonhyuk , Lim Hyeongjoon , Moon Seongphill , Rhyee Jong-Soo , Kwon Yong Seung , Smirnov Dmitry , Choi E. J. 
Published: July 2023

Abstract
We performed optical reflectivity measurements on the cubic pnictide semimetal LaSb. The optical conductivity, calculated from the reflectivity, shows that two Drude carriers with drastically different scattering rates coexist: one carrier (D1) with moderate scattering rate γ1 (= 130 cm−1) and the other (D2) with very low scattering rate γ2 (= 0.116 cm−1). The ratio between these two scattering rates is as large as γ1/γ2 = 1120, which stands in sharp contrast to other semimetals such as Bismuth (Bi), where γ1/γ2 = 2.9. The coexistence of two carriers, D1 and D2, with such drastically different scattering rates demonstrates that LaSb is an unconventional semimetal. To investigate the origins of the two carriers, D1 and D2, we calculate their optical spectral weights and compare them with those of the existing carriers in LaSb, namely, bulk electron, bulk hole, linear-dispersing band electron, and Dirac-like surface carrier. This quantitative analysis suggests that D1 arises from the semimetal band electron, while D2 originates from the semimetal band hole, respectively. The coexistence of the ultra-high mobility and moderate mobility carriers provides new insights on the electrical transport of this material including, importantly, the mechanism behind the extreme magneto resistance effect of LaSb.
Scalable quasi-static self-modeling for physical legged locomotion
Authors: Hu Yuhang , Kwiatkowski Robert , Chen Boyuan , Wyder Philippe , Lipson Hod 
Published: July 2023

Abstract
Self-modeling refers to an agent's ability to learn a predictive model of its own behavior. A continuously adapted self-model can serve as an internal simulator, enabling the agent to plan and assess various potential behaviors internally, reducing the need for expensive physical experimentation. Self-models are especially important in legged locomotion, where manual modeling is difficult, reinforcement learning is slow, and physical experimentation is risky. Here, we propose a Quasi-static Self-Modeling framework that focuses on learning a predictive model only of high-level quasi-static dynamics, rather than a continuous model. Experimental results on a 12-degree-of-freedom-legged robot demonstrate improvements over model-free and traditional model-based continuous approaches. Using 80 diverse robot morphologies, we confirm a correlation of R2=0.94 between the improvements rendered by our method and the DoF of the robot, suggesting that as future robots increase in complexity, this approach will become more valuable.
Goursat Lemma on groups with operators
Authors: Pankiti Pascal , Jugnia Célestin Nkuimi 
Published: July 2023

Abstract
In this paper the usual Goursat lemma, which describes subgroups of the directproduct of two groups and finite number of groups, is generalized to describingsubgroups of two groups with operators and direct product of a finite number ofgroups with operators. Other possible generalizations are discussed and applications characterizing commutative group with operators of the direct product of twogroups with operators are given. Most of these applications are some characterization of commutative sub-group with operators of the direct product of two groupswith operators. Other we give a characterization of subgroups of a direct productwhich are inner semi-direct products. The applications of the Goursat lemma ongroups with operators are also found in the modules. For two modules A and Bon a ring R, we use easily Goursat lemma for groups with operators to characterize the sub-modules of the direct product A × B which are finitely generated,noetherian sub-modules of A × B their divisible and torsion sub-modules.
AMS subject classification: 06F07, 18D10