bluuebunny/crossref_metadata_2025_split huggingface dataset:
KAJIAN YURIDIS PRAKTIK PERSEKONGKOLAN DALAM TENDER (Studi Putusan KPPU Perkara Nomor 24/KPPU-I/2016)
Authors: Az Zarah Intania 
Published: July 2023

<p><em>This research aims to determine the consideration of a conspiracy in the Commission decision on Case No. 24 / KPPU-I / 2016 and implementation of legal justice in the Commission’s Decision Case No. 24 / KPPU-I / 2016 in terms of economic and fairness aspects. This research</em> <em>is a normative law research which are prescriptive and applied. The approach used are the statute approach and the case approach. The sources of legal materials consist of primary legal materials, secondary and tertiary legal materials with literature study. This research used deductive analysis technique. Commission’s in Decision Number 24 / KPPU-I / 2016 has considered on the case in accordance with Law No. 5 of 1999, however its considerations do not consider whether the consequences of the conspiracy are hindering business competition or not. The commission in deciding the Commission Case Number 24 / KPPU-I / 2016 tended to only pay attention to the justice aspect while the economic aspect seemed a little neglected, so that the KPPU Decision Number 24 / KPPU-I / 2016 did not fully fulfill legal justice.</em></p><p><strong><em>Keywords: Tender Conspiracy; Business Competition; Fairness</em></strong><em></em></p>
XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
Authors: Sun Yifei , Zhang Yihan , Zhang Jifeng , Chen Y. Eugene , Jin Jian-Ping , Zhang Kezhong , Mou Hongmei , Liang Xiubin , Xu Jie 
Published: July 2023

Abstract
Background :
sodium-dependent glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2, respectively. SGLT-2 is almost exclusively expressed in the renal proximal convoluted tubule cells. SGLT-1 is expressed in the kidneys but also in other organs throughout the body. Many SGLT inhibitor drugs have been developed based on the mechanism of blocking glucose (re)absorption mediated by SGLT1/2, and several have gained major regulatory agencies’ approval for treating diabetes. Intriguingly these drugs are also effective in treating diseases beyond diabetes, for example heart failure and chronic kidney disease. We recently discovered that SGLT-1 is upregulated in the airway epithelial cells derived from patients of cystic fibrosis (CF), a devastating genetic disease affecting greater than 70,000 worldwide.
Results:
in the present work, we show that the SGLT-1 upregulation is coupled with elevated endoplasmic reticulum (ER) stress response, indicated by activation of the primary ER stress senor inositol-requiring protein 1a(IRE1a) and the ER stress-induced transcription factor X-box binding protein 1 (XBP1), in CF epithelial cells, and in epithelial cells of other stress conditions. Through biochemistry experiments, we demonstrated that XBP1 acts as a transcription factor for SLC5A1 by directly binding to its promoter region. Targeting this ER stress ® SLC5A1 axis by either the ER stress inhibitor Rapamycin or the SGLT-1 inhibitor Sotagliflozin was effective in attenuating the ER stress response and reducing the SGLT-1 levels in these cellular model systems.
Conclusions:
the present work establishes a causal relationship between ER stress and SGLT-1 upregulation and provides a mechanistic explanation why SGLT inhibitor drugs benefit diseases beyond diabetes.
Measurements of the Corpus Callosum in epileptic patients Using Magnetic Resonance Imaging
Authors: Sharifi Yasaman , Rahimian Elham , Rafaati Ali , Tafakhori Abbas 
Published: July 2023

Abstract

Background and Purpose:
In recent years, magnetic resonance imaging (MRI) has been used to evaluate seizures in patients with epilepsy. The Corpus callosum (CC) serves as a crucial communication structure between the two brain hemispheres, making it valuable to study MRI changes in patients with epilepsy. This study aimed to measure the CC in patients with epilepsy and report any structural differences.
Materials and Methods:
We conducted a cross-sectional study involving 150 patients diagnosed with epilepsy. T2W MRI mid-sagittal cuts were taken to measure the length and width of the middle third of the CC.
Results:
The mean length of the CC was 6.89 ± 0.59 cm, while the mean width of the middle third of the CC was 3.23 ± 1.3 mm. Significant correlations were found between CC measurements and factors such as the number of drugs used, drug resistance, refractory epilepsy (RE), and the presence of MRI lesions.
Conclusion:
The results demonstrate that epilepsy affects the CC, and there is likely a correlation between CC width, the number of drugs used, drug resistance, and the presence of primary lesions in MRI. These findings can contribute to further studies on prognostic factors in epilepsy.
Purine and pyrimidine metabolism regulatory gene signature predicts prognosis and immunotherapy efficiency in breast cancer
Authors: Chang Lidan , Cui Hanxiao , Ren Xueting , Dai Luyao , Zhai Zhen , Xiao Zhengtao , Wu Hao , Kang Huafeng , Ma Xiaobin 
Published: July 2023

Abstract
BACKGROUND Breast cancer (BC) is a heterogeneous disease with diverse molecular features and outcomes. Purine and pyrimidine (PP) metabolism provide sufficient nucleotides for tumor growth. Thus, the relationship between PP metabolism and BC needs a thorough exploration.METHODS Based on the 115 PP genes and BC multi-omics data, we performed consensus clustering and functional enrichment analyses to explore the biological characteristic. After the LASSO regression and multi-Cox regression analyses, a PP gene-related signature was developed. Moreover, data from the GSE45255, GSE21653, and GSE118389 cohorts, analyses included immunophenoscore (IPS) and single-cell RNA sequencing were employed to validate the predictability. Additionally, drug sensitivity and a comprehensive nomogram were explored for clinical practice.RESULTS PP genes were predominantly enriched in pathways related to immune stimulation, tumor aggressiveness, and EMT development. We identified three BC subtypes that possess different outcomes and immunological characteristics. We constructed an eleven-gene signature (SHCBP1, SSBP2, EIF4EBP1, FHL5, ACTL8, KLF9, IGKC, SEMA3B, CXCL1, CSTA, and IGLL5) that can be effectively for risk stratification, and was positively correlated with most T cell exhaustion-related genes (P < 0.05). The low-risk group possessed a better tumor microenvironment (P < 0.001), a higher expression level of immune checkpoint genes (P < 0.05), and showed immunotherapy benefits (P < 0.05). In addition, immune infiltrating cells demonstrated a characteristic distribution between the different risk groups (P < 0.05). Notably, patients with low-risk scores showed higher sensitivity to targeted drugs (veliparib, olaparib, and palbociclib), as well (P < 0.001).CONCLUSION PP metabolism regulatory gene signature suggests that patients assessed as low-risk have a better prognosis, immune microenvironment, and immunotherapy responses. It also inspired the exploration of biomarkers and provided novel strategies for clinical practice.
Indicators of suspended sediment transport dynamics in rivers
Authors: Shin Jae hun , Grabowski Robert C. , Holman Ian 
Published: July 2023

Abstract

Suspended sediment (SS) is a natural component of rivers, but elevated SS concentrations (SSCs) can impact aquatic ecosystems and engineering infrastructures. However, a significant gap remains in predicting SSC dynamics, which are influenced by catchment and climate factors that control sediment erosion, transport and deposition. The research aim is to develop and apply new SS transport dynamics indicators to determine how SSC varies spatially and temporally at a continental scale. Daily SSC data (mg/l) from 1,425 gauging stations in the US were used to calculate indicators of magnitude, frequency and timing (MFT). A filtering approach was applied to calculate frequency indicators that capture SSC events of differing durations. Spatial patterns in indicators were examined and integrated using K-means clustering. High SSC was identified at sites in dry and mountainous regions, but longer-duration SSC events were found in the northern US. The western coastal region and Puerto Rico had consistent timings of high SSC (winter and autumn, respectively). SSC magnitude had a decreasing trend over time across most of the US, but increasing trends were identified for the duration of SSC events. The use of MFT indicators is recommended for future studies to support prediction of climate change impacts on SSC.
HCST Expression Distinguishes Immune-hot and Immune-cold Subtypes in Pancreatic Ductal Adenocarcinoma
Authors: Ma Boyi , Zhang Dai-jun , Hu Yabin , Chen Xianghan , Gong Ruining , Lei Ke , Yu Qian , Ren He 
Published: July 2023

Introduction:
Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent malignancy
of the pancreas, and the incidence of this disease is approximately equivalent to the mortality rate.
Immunotherapy has made a remarkable breakthrough in numerous cancers, while its efficacy in
PDAC remains limited due to the immunosuppressive microenvironment. Immunotherapy efficacy is
highly correlated with the abundance of immune cells, particularly cytotoxic T cells. Therefore, molecular
classifier is needed to identify relatively hot tumors that may benefit from immunotherapy.

Methods:
In this study, we carried out a transcriptome analysis of 145 pancreatic tumors to define the underlying
immune regulatory mechanism driving the PDAC immunosuppressive microenvironment. The
immune subtype was identified by consensus clustering, and the underlying PDAC immune activation
mechanism was thoroughly examined using single sample gene set enrichment analysis (ssGSEA). Area
under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the accuracy
of the molecular classifier in differentiating immunological subgroups of PDAC.5

Results:
The protein level of molecular classifier was verified by immunohistochemistry in human
PDAC tissue. Immune-hot tumors displayed higher levels of immune cell infiltration and immune
checkpoint, in line with enriched immune escape pathways. Hematopoietic cell signal transducer
(HCST), a molecular classifier used to differentiate immunological subtypes of PDAC, has shown a
substantial link with the expression levels of cytotoxic markers, such as CD8A and CD8B. At the single
cell level, we found that HCST was predominantly expressed in CD8T cells. By immunohistochemistry
and survival analysis, we further demonstrated the prognostic value of HCST in PDAC.

Conclusion:
We identified HCST as a molecular classifier to distinguish PDAC immune subtypes,
which may be useful for early diagnosis and targeted therapy of PDAC.
Follicular Helper T Cells in Peyer's Patches and Galactose-
Deficient Iga1 Contribute to Iga Nephropathy
Authors: Huang Yuye , Sun Xunling , Nie Guoming , Xu Hongtao , Zou Minshu 
Published: July 2023

Background:
Common primary glomerulonephritis with aberrant mucosal
immunity is IgA nephropathy (IgAN). T follicular helper (TFH) cells are essential in
regulating B cell differentiation. Peyer’s patches (PPs) are the main site where IgA+
plasmablasts differentiate.

Objective:
Our study aimed to investigate the TFH cell's potential contribution to the
etiology of IgA nephropathy.

Materials and Methods:
In PPs from IgAN mouse models, the ratio of the TFH cell, B220+IgA+,
B220+IgM+, and B220-IgA+ lymphocytes were assessed. Then, we used Western blot
to assess the expression of Bcl-6, Blimp- 1, and IL-21 proteins in PPs and used RTPCR
to assess the expression of IL-21 and TGF-β1 mRNA. TFH cells coculture with
spleen cells to measure the degree of IL-21 and the ratio of activation marker CD69 on
the TFH cells. Naive B cells (CD27-IgD+) from children suffering from IgAN were
cultured with TFH cell-related cytokines. The supernatant was detected to assess the
excretion of galactose-deficient IgA1 (Gd-IgA1).

Results:
IgAN mice developed noticeably increased degrees of IL-21 and CD69 on
TFH cells than controls did, as well as higher percentages of B220+IgA+, B220+IgM+,
B220+IgA+, TGF- β1, and IL-21 mRNA and Bcl-6, IL-21 proteins in PPs. The Gd-IgA1
level in the supernatant and IgAN- positive children's serum were noticeably higher than
those of the healthy controls (P < 0.05). PPs provide the microenvironment to induce
the production of IgA-secreting plasmablasts.

Conclusion:
TFH cells may be a key moderator to induce B cell differentiation into IgAsecreting
plasmablasts and produce Gd-IgA1, which plays a significant part in IgAN’s
pathogenesis. It could be a new therapeutic target in the future.
Antioxidant, Antibacterial, α-Amylase, and α-Glucosidase Inhibition, and
Anti-inflammatory Activities of Mimosa Rubicaulis Lam.
Authors: Adhikari Achyut , Shrestha Dipesh , Thapa Sushma , Pokhrel Tamlal , Sinjali Bishnu Bahadur , Baral Janaki 
Published: July 2023

Background:
The use of medicinal plants as supplemental or alternative medicine is
widespread around the world. For the development of new drugs, studies on these medicinal plants
that include pharmacological and toxicological assessments are crucial.

Objective:
This work aimed to find the total phenolic and flavonoid content, antioxidant, antibacterial,
and antidiabetic potential of the traditionally used medicinal plant Mimosa rubicaulis Lam.

Methods:
The in vitro antidiabetic potential of methanolic extract and its fractions of the roots of
M. rubicaulis were performed via enzyme (α-glucosidase and α-amylase) inhibition assays. Antioxidant
and anti-inflammatory activities were carried out using 2,2 Diphenyl-1-picrylhydrazyl
(DPPH), and reactive oxygen species (ROS) inhibiting methods. Well diffusion method is applied
for antibacterial activity.

Results:
The crude extract reported the highest inhibition activity against α-glucosidase with an
IC50 value of 10.29 ± 0.35 μg/mL compared to the standard acarbose’s IC50 value of 5.653 ± 0.29
μg/mL. Similarly, the ethyl acetate (EA) fraction disclosed significant inhibition against α-amylase
with an IC50 value of 108.7 ± 0.66 μg/mL compared to the standard acarbose’s IC50 value of 6.01 ±
0.14 μg/mL. Likewise, the EA fraction showed the maximum antioxidant activity with an IC50 value
of 11.89 ± 1.05 μg/mL among the crude extract and its fractions.

Conclusion:
Mimosa rubicaulis was found to have α-glucosidase and α-amylase inhibition, antiinflammatory,
and antibacterial activity. To the best of our knowledge, this is the first report of α-
glucosidase and α-amylase inhibition activity of this plant. Further studies on this plant are required
to isolate potent compounds.
How Do Investors Respond to Targets’ Interim Earnings?
Authors: Gunn Rita , Pierce Spencer , Romney Miles 
Published: July 2023

ABSTRACT
Fundamental to the accounting literature is that firms’ stock prices relate positively to their earnings news. We examine a setting where investors may be unsure to which firm the announced earnings accrue: earnings announced by acquisition targets between the announcement and completion of the acquisition. We find targets’ stock prices relate positively to their unexpected earnings during this interim period but only for unsuccessful M&A deals. For completed deals, we fail to find that targets’ or acquirers’ stock prices respond to targets’ unexpected interim earnings at the time of announcement. However, we find that targets’ interim earnings predict future returns of the combined firm following deal completion. A trading strategy based on targets’ interim earnings produces economically significant annualized abnormal returns of 7.25 percent. Our findings suggest investors respond inefficiently to the earnings that targets announce between the announcement and completion of acquisitions.
Data Availability: Data are available from the public sources cited in the text.
JEL Classifications: M40; M41; G34.
Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons
Authors: Kim Kwang Kon , Lee Tae Hwan , Park Byong Seo , Kang Dasol , Kim Dong Hee , Jeong Bora , Kim Jin Woo , Yang Hye Rim , Kim Han Rae , Jin Sungho , Back Sung Hoon , Park Jeong Woo , Kim Jae Geun , Lee Byung Ju 
Published: July 2023

Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress–induced unfolded protein response (UPR). In mammals, eIF2α is phosphorylated by overnutrition-induced ER stress and is related to the development of obesity. Here, we studied the function of phosphorylated eIF2α (p-eIF2α) in agouti-related peptide (AgRP) neurons using a mouse model (AgRPeIF2αA/A) with an AgRP neuron–specific substitution from Ser 51 to Ala in eIF2α, which impairs eIF2α phosphorylation in AgRP neurons. These AgRPeIF2αA/A mice had decreases in starvation-induced AgRP neuronal activity and food intake and an increased responsiveness to leptin. Intriguingly, impairment of eIF2α phosphorylation produced decreases in the starvation-induced expression of UPR and autophagy genes in AgRP neurons. Collectively, these findings suggest that eIF2α phosphorylation regulates AgRP neuronal activity by affecting intracellular responses such as the UPR and autophagy during starvation, thereby participating in the homeostatic control of whole-body energy metabolism.

Article Highlights
This study examines the impact of eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, triggered by an energy deficit, on hypothalamic AgRP neurons and its subsequent influence on whole-body energy homeostasis. Impaired eIF2α phosphorylation diminishes the unfolded protein response and autophagy, both of which are crucial for energy deficit–induced activation of AgRP neurons. This study highlights the significance of eIF2α phosphorylation as a cellular marker indicating the availability of energy in AgRP neurons and as a molecular switch that regulates homeostatic feeding behavior.
Couple-based interventions for secondary and tertiary prevention of intimate partner violence: A systematic review of randomized controlled trials
Authors: Emalia Faiqa Himma , Afiyanti Yati , Rachmawati Imami Nur 
Published: July 2023

Background: Intimate partner violence (IPV) is the most tragic form of gender inequality and has devastating effects on women worldwide. A couple/family-based intervention approach has been developed and tested to address obstacles preventing intimate partner violence.
Purpose: This review aimed to examine couple-based interventions for secondary and tertiary intimate partner violence prevention.
Methods: The researcher searched the electronic databases ProQuest, Scopus, PubMed, Science Direct, SpringerLink, and Taylor & Francis for relevant articles. This review includes English/Indonesian research articles published between 2012 and 2022. This study reviewed various types of secondary and tertiary intimate partner violence prevention interventions and their effectiveness in reducing the incidence of intimate partner violence against women. Risk of bias assessment was performed used A Revised Cochrane Risk of Bias Tools for Randomized Controlled Trial (RoB 2).
Results: From the search findings, 1,819 articles were found, of which fifteen were included in the review, comprising twelve secondary preventive interventions and three tertiary prevention interventions make up these fifteen articles. Couple-based interventions for secondary prevention include gender transformative interventions, enhancing relationships with partners, bolstering the family economy, and encouraging men's participation in women's reproductive health and parenting. Cognitive-behavioral therapy predominates interventions for tertiary prevention to eliminate risk factors.
Conclusion: This article recommends using couple-based interventions under the population's inherent risk factors and pays close attention to the safety of the implementation process.
EFEKTIVITAS PELAKSANAAN PROGRAM BACA TULIS AL QUR’AN (BTQ ) TERHADAP PENINGKATAN KEMAHIRAN BACA TULIS AL-QUR’AN PADA MAHASISWA SEMESTER III JURUSAN PENDIDIKAN AGAMA ISLAM FAKULTAS TARBIYAH DAN KEGURUAN UIN ALAUDDIN MAKASSAR
Authors: Rusmin B Muhammad , Abu Bakar Abd. Syukur , Mosiba Risna 
Published: July 2023

This journal discusses "The Effectiveness of the Implementation of the BTQ Program on Increasing Reading and Writing Proficiency in the Qur'an in Semester III Students Class of 2020 majoring in Islamic Religious Education, Faculty of Tarbiyah and Teacher Training UIN Alauddin Makassar". The problems discussed in this thesis are 1. How is the Implementation of the BTQ Program to Improve Reading and Writing Al-Qur'an Proficiency in Semester III Students Class of 2020 majoring in Islamic Religious Education 2. How is the Effectiveness of the BTQ Program to Increasing Al-Qur'an Reading Proficiency in Semester III Students Class of 2020 majoring in Islamic Religious Education.
This type of research is Quantitative where the data is in the form of numbers and uses statistical analysis. The population in this study were all Semester III students Batch 2020 majoring in Islamic Religious Education at the Tarbiyah and Teacher Training Faculty of UIN Alauddin Makassar, totaling 194 people. While the sample is 15% of the 30 students with the sampling technique using Random Sampling.
Based on the results of collecting and processing data using descriptive statistical analysis, the authors can conclude that the implementation of the BTQ Program in improving Al-Qur'an reading and writing skills in Semester III Students Class of 2020 majoring in Islamic Religious Education, Faculty of Tarbiyah and Teacher Training UIN Alauddin Makassar is considered very effective because in practice it is in accordance with the established rules as stated by the respondent.
The results of the analysis of inferential statistical testing, namely the t test, obtained the results of the hypothesis test that t_0 = 1.071 and t_table = 2.048. t_0<t_table (1.071 <2.048) then H_o is rejected H_I is accepted. Thus it can be concluded that there is a significant influence. The implementation of the BTQ program is very effective on the reading and writing ability of the Qur'an of students majoring in Islamic Religious Education, Faculty of Tarbiyah and Teacher Training, UIN Alauddin Makassar.
The implications for this research are that based on the results of the research, the authors think that it is necessary to maintain and support the implementation of the BTQ program at UIN Alauddin Makassar.