bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a CT image analysis-based scoring system to differentiate gastric schwannomas from gastrointestinal stromal tumors
Authors: Zhang Sheng , Yang Zhiqi , Chen Xiaofeng , Su Shuyan , Huang Ruibin , Huang Liebin , Shen Yanyan , Zhong Sihua , Zhong Zijie , Yang Jiada , Long Wansheng , Zhuang Ruyao , Fang Jingqin , Dai Zhuozhi , Chen Xiangguang 
Published: June 2023

PurposeTo develop a point-based scoring system (PSS) based on contrast-enhanced computed tomography (CT) qualitative and quantitative features to differentiate gastric schwannomas (GSs) from gastrointestinal stromal tumors (GISTs).MethodsThis retrospective study included 51 consecutive GS patients and 147 GIST patients. Clinical and CT features of the tumors were collected and compared. Univariate and multivariate logistic regression analyses using the stepwise forward method were used to determine the risk factors for GSs and create a PSS. Area under the receiver operating characteristic curve (AUC) analysis was performed to evaluate the diagnostic efficiency of PSS.ResultsThe CT attenuation value of tumors in venous phase images, tumor-to-spleen ratio in venous phase images, tumor location, growth pattern, and tumor surface ulceration were identified as predictors for GSs and were assigned scores based on the PSS. Within the PSS, GS prediction probability ranged from 0.60% to 100% and increased as the total risk scores increased. The AUC of PSS in differentiating GSs from GISTs was 0.915 (95% CI: 0.874–0.957) with a total cutoff score of 3.0, accuracy of 0.848, sensitivity of 0.843, and specificity of 0.850.ConclusionsThe PSS of both qualitative and quantitative CT features can provide an easy tool for radiologists to successfully differentiate GS from GIST prior to surgery.
Therapeutic strategies to overcome EGFR mutations as acquired resistance mechanism in ALK-rearranged non-small-cell lung cancer: Case Reports
Authors: Michaux Lionel , Perrier Alexandre , Mehlman Camille , Alshehhi Hussa , Dubois Antonin , Lacave Roger , Coulet Florence , Cadranel Jacques , Fallet Vincent 
Published: June 2023

IntroductionALK tyrosine kinase inhibitors (ALK TKIs) have improved prognosis in ALK-rearranged (ALK+) non-small-cell lung cancer (NSCLC). However, drug resistance mechanisms occur inevitably during the course of treatment leading to disease progression. Activation of epidermal growth factor receptor (EGFR) bypass signaling pathway is an uncommon cause of acquired resistance to ALK TKIs.MethodWe present two patients with EML4-ALK rearranged NSCLC, developing an acquired EGFR resistance mutation after receiving multiple lines of ALK TKIs.ResultsWhile preclinical models have showed encouraging data, there is a critical need for clinical studies on treatment strategies to overcome this drug resistance. Three real-life therapeutic approaches were used in this report: i) using brigatinib, an inhibitor targeting both ALK and EGFR tyrosine kinases; ii) combining two ALK TKIs together; and iii) delivering doublet platinum chemotherapy. In case 1, time to treatment failure (TTF) was 9.5 months with brigatinib; in case 2, TTF was 10 months with combined TKIs (osimertinib and brigatinib), whereas TTF with chemotherapy was only 2 months. Tolerability profile TKIs combotherapy was acceptable.ConclusionThese case reports underline the therapeutic complexity of EGFR-acquired resistance mutation in ALK+ NSCLC and offers some leads to solve this real-life clinical challenge.
Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
Authors: Alafnan Ahmed , Khalifa Nasrin E. , Hussain Talib , Osman Mhdia Elhadi 
Published: June 2023

Introduction: Among numerous triterpenoids of the Cucurbitaceae family, Cucurbitacin-B (Cur-B) is being explored for its pharmacological attributes. Reports from previous studies have explicitly shown that Cur-B possesses substantial anticancer effects. The present report focuses on exploring the anticancer attributes of Cur-B against androgen-dependent PCa LNCaP cells.Methods: LNCaP cells were exposed to commercially available purified Cur-B at varying concentrations that were selected as 5, 10, 15, 20, and 25 µM for some time of 24 h to perform various experimental studies.Results: Cytotoxicity evaluation revealed that Cur-B impeded the LNCaP cell’s viability at 5 µM (p &lt;0.05) which increased considerably at a concentration of 25 µM (p &lt;0.001). Cur-B was also efficacious in inducing the changes within nu-clear morphology followed by a concomitant increase in the activities of key caspases including caspase-3, -8, and -9 intriguingly in a dose-dependent trend. Cur-B treatment not only resulted in the augmentation of intracellular ROS levels within LNCaP cells at 5 µM (p &lt;0.05) but also in-creased significantly at 25 µM concentration (p &lt;0.001). Elevation in the ROS levels was also found to be correlated with dissipated mitochondrial membrane potential (ΔΨm) which culminated in the onset of significant apoptosis at 25 µM concentration (p &lt;0.001). Cur-B exposure also resulted in the downregulation of cyclin D1, cyclin-dependent kinase 4 (CDK4) followed by amplified levels of p21Cip1 mRNA. Importantly, exposure of Cur-B competently reduced the expression of the Notch signaling cascade which may be the plausible cause behind Cur-B-instigated apoptotic cell death and cell cycle arrest in LNCaP cells.Discussion: These observations thus, explicitly indicated that Cur-B could be plausibly further explored as potent therapeutics against androgen-dependent PCa.
Sex differences in long-term effects of collagen-induced arthritis in middle-aged mice
Authors: Schuh Bernhard Maximilian , Macáková Kristína , Feješ Andrej , Groß Tim , Belvončíková Paulína , Janko Jakub , Juskanič Dominik , Hollý Samuel , Borbélyová Veronika , Šteňová Emőke , Pastorek Michal , Vlková Barbora , Celec Peter 
Published: June 2023

Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory disorder with high prevalence among middle-aged women. Collagen-induced arthritis (CIA) is the most widely used animal model of RA, however, sex differences and long-term effects of CIA in mice are poorly described in the literature.Aim: Therefore, the present study aimed to analyze the long-term effects of CIA on the joints of middle-aged mice of both sexes and to describe potential sex differences.Materials and methods: CIA was induced in middle-aged DBA/1J mice by immunization with bovine type II collagen and complete Freund’s adjuvant. Saline was administered to control mice. Arthritis score assessment, plethysmometry, and thermal imaging of the joints were performed weekly for 15 weeks. Locomotor activity, micro-computed tomography, joint histology and biochemical analyses were performed at the end of the experiment.Results: Our results indicate a similar prevalence of arthritis in both sexes of mice—67% (8/12) of females and 89% (8/9) males with an earlier onset in males (day 14 vs. day 35). After the arthritis scores peaked on day 56 for males and day 63 for females, they steadily declined until the end of the experiment on day 105. A similar dynamics was observed in paw volume and temperature analyzing different aspects of joint inflammation. Long-term consequences including higher proteinuria (by 116%), loss of bone density (by 33.5%) and joint damage in terms of synovial hyperplasia as well as bone and cartilage erosions were more severe in CIA males compared to CIA females. There were no significant differences in locomotor activity between CIA mice and CTRL mice of any sex.Conclusion: This is the first study to describe the long-term effects of the CIA model in terms of sex differences in DBA/1J mice. Our results indicate sex differences in the dynamics, but not in the extent of arthritis. An earlier onset of arthritis and more severe consequences on joints, bones and kidneys were found in males. The underlying immune pathomechanisms responsible for the limited duration of the arthritis symptoms and the opposite sex difference in comparison to RA patients require further investigation.
The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies
Authors: Gou Xin-yun , Li Yu-xi , Guo Liu-xue , Zhao Jing , Zhong Dong-ling , Liu Xiao-bo , Xia Hai-sha , Fan Jin , Zhang Yue , Ai Shuang-chun , Huang Jia-xi , Li Hong-ru , Li Juan , Jin Rong-jiang 
Published: June 2023

BackgroundDepression is generally accompanied by a disturbed conscious processing of emotion, which manifests as a negative bias to facial/voice emotion information and a decreased accuracy in emotion recognition tasks. Several studies have proved that abnormal brain activation was responsible for the deficit function of conscious emotion recognition in depression. However, the altered brain activation related to the conscious processing of emotion in depression was incongruent among studies. Therefore, we conducted an activation likelihood estimation (ALE) analysis to better understand the underlying neurophysiological mechanism of conscious processing of emotion in depression.MethodElectronic databases were searched using the search terms “depression,” “emotion recognition,” and “neuroimaging” from inceptions to April 10th, 2023. We retrieved trials which explored the neuro-responses of depressive patients to explicit emotion recognition tasks. Two investigators independently performed literature selection, data extraction, and risk of bias assessment. The spatial consistency of brain activation in conscious facial expressions recognition was calculated using ALE. The robustness of the results was examined by Jackknife sensitivity analysis.ResultsWe retrieved 11,365 articles in total, 28 of which were included. In the overall analysis, we found increased activity in the middle temporal gyrus, superior temporal gyrus, parahippocampal gyrus, and cuneus, and decreased activity in the superior temporal gyrus, inferior parietal lobule, insula, and superior frontal gyrus. In response to positive stimuli, depressive patients showed hyperactivity in the medial frontal gyrus, middle temporal gyrus, and insula (uncorrected p &lt; 0.001). When receiving negative stimuli, a higher activation was found in the precentral gyrus, middle frontal gyrus, precuneus, and superior temporal gyrus (uncorrected p &lt; 0.001).ConclusionAmong depressive patients, a broad spectrum of brain areas was involved in a deficit of conscious emotion processing. The activation of brain regions was different in response to positive or negative stimuli. Due to potential clinical heterogeneity, the findings should be treated with caution.Systematic review registrationhttps://inplasy.com/inplasy-2022-11-0057/, identifier: 2022110057.
The relationship between self-cohesion and smartphone addiction: the mediating role of rejection sensitivity
Authors: El Keshky Mogeda El Sayed , Aseem Huda , Alzain Amira , Samak Yasser Abdelazim Abdelmawgoud 
Published: June 2023

BackgroundThe increasing use of smartphones with attractive applications has yielded concerns over problematic overuse, also called smartphone addiction, thus creating a need to investigate the antecedents and pathways of this addiction.ObjectiveThe aim of this study was to investigate the relationships between the self-cohesion dimensions of presence and consistency and smartphone addiction, and the potentially mediating role of rejection sensitivity.MethodsA total sample of 910 respondents (58% females, mean age = 34.9, SD = 13.6) participated in the study. They completed a questionnaire including demographic characteristics and queries about frequency and duration of smartphone use, as well as the Self-Cohesion Scale, the Short Version of Smartphone Addiction Scale, and the Rejection Sensitivity RS-Adult Questionnaire. Structural equation modeling was used to examine the relationships in question.ResultsThe findings indicated that smartphone addiction was positively correlated with rejection sensitivity and negatively correlated with the self-cohesion dimensions of presence and consistency. Further, both presence and consistency were negatively associated with smartphone addiction and rejection sensitivity negatively mediated these relationships.ConclusionSelf-cohesion and rejection sensitivity appear to be important predictors of smartphone addiction. Efforts to counteract smartphone addiction should, therefore, endeavor to increase smartphone users’ self-cohesion and reduce their rejection sensitivity.
Increasing incidence of Plasmodium ovale and persistent reporting of Plasmodium vivax in imported malaria cases: an analysis of 9-year surveillance data in four areas of China
Authors: Wang Xiaoxiao , Xu Wenjie , Luo Fei , Lin Kangming , Zhang Tao , Yao Linong , Zhang Xuan , Zhang Jiaqi , Auburn Sarah , Wang Duoquan , Ruan Wei 
Published: June 2023

BackgroundThis study aimed at exploring the epidemiological pattern of imported malaria in China before malaria elimination in 2021, to provide evidence-based data for preventing malaria re-establishment in China.MethodsNine-year surveillance data on imported malaria in four provincial-level administrative divisions (PLADs) (Anhui, Chongqing, Guangxi, and Zhejiang) between 2011 and 2019 were thoroughly collected and analyzed.ResultsA quite stable trend in imported malaria cases between 2011 and 2019 was observed. In total, 6,064 imported patients were included. Plasmodium falciparum was the most frequently reported species (4,575, 75.6%). Cases of malaria were most frequently imported from Western Africa (54.4%). We identified an increasing trend in P. ovale and a persistence of P. vivax infections among the cases of malaria imported from Western Africa. Most patients (97.5%) were 20–50 years old. Among imported malaria infections, the main purposes for traveling abroad were labor export (4,914/6,064, 81.0%) and business trips (649, 10.7%). Most patients (2,008/6,064, 33.1%) first visited county-level medical institutions when they sought medical help in China. More patients were diagnosed within 3 days after visiting Centers for Disease Control and Prevention (CDCs) or entry–exit quarantine facilities (EQFs) (1,147/1609, 71.3%) than after visiting medical institutions (2,182/3993, 54.6%).ConclusionImported malaria still poses a threat to the malaria-free status of China. County-level institutions are the primary targets in China to improve the sensitivity of the surveillance system and prevent the re-establishment of malaria. Health education should focus on exported labors, especially to Western and Central Africa. Increasing trend in P. ovale and persistence of P. vivax infections indicated their underestimations in Western Africa. Efficient diagnostic tools and sensitive monitoring systems are required to identify Plasmodium species in Africa.
A novel triplex real-time PCR assay for the differentiation of lumpy skin disease virus, goatpox virus, and sheeppox virus
Authors: Nan Wenlong , Gong Mingxia , Lu You , Li Jinming , Li Lin , Qu Hailong , Liu Chunju , Wang Ying , Wu Faxing , Wu Xiaodong , Wang Zhiliang , Chen Yiping , Peng Daxin 
Published: June 2023

IntroductionThree members of Capripoxvirus (CaPV) genus, including lumpy skin disease virus (LSDV), goatpox virus (GTPV), and sheeppox virus (SPPV), are mentioned as notifiable forms by World Organization for Animal Health. These viruses have negatively impacted ruminant farming industry worldwide, causing great economic losses. Although SPPV and GTPV cause more severe clinical disease in only one animal species, they can transfer between sheep and goats. Both homologous and heterologous immunization strategies are used to protect animals against CaPVs. However, development of accurate and rapid methods to distinguish these three viruses is helpful for the early detection, disease surveillance, and control of CaPV infection. Therefore, we developed a novel triplex real-time PCR (qPCR) for the differentiation of LSDV, GTPV, and SPPV.MethodsUniversal primers were designed to detect pan-CaPV sequences. Species-specific minor groove binder (MGB)-based probes were designed, which were labeled with FAM for LSDV, HEX for GTPV, and ROX for SPPV. The sensitivity, specificity, reproducibility, and ability of detecting mixed infections were evaluated for the triplex qPCR. Further, 226 clinical samples of the infection and negative controls were subjected to the triplex qPCR, and the results were verified using PCR-restriction fragment length polymorphism (PCR-RFLP) and sequencing methods for PRO30 gene.ResultsThe triplex qPCR could successfully distinguish LSDV, GTPV, and SPPV in one reaction, and the assay sensitivity was 5.41, 27.70, and 17.28 copies/μL, respectively. No cross-reactivity was observed with other viruses causing common ruminant diseases, including des petits ruminants virus, foot-and-mouth disease virus, bluetongue virus, ovine contagious pustular dermatitis virus, infectious bovine rhinotracheitis virus, and bovine viral diarrhea-mucosal disease virus. Inter-and intra-assay variabilities were &lt; 2.5%. The results indicated that the triplex qPCR was highly specific, sensitive, and reproducible. Simulation experiments revealed that this assay could successfully distinguish two or three viruses in case of mixed infections without any cross-reaction. For clinical samples, the results were completely consistent with the results of PCR-RFLP and sequencing. This demonstrated that the assay was reliable for clinical application.DiscussionThe triplex qPCR is a robust, rapid, and simple tool for identifying various types of CaPV as it can successfully distinguish LSDV, GTPV, and SPPV in one reaction. Furthermore, the assay can facilitate more accurate disease diagnosis and surveillance for better control of CaPV infection.
PERANCANGAN SISTEM KONTROL DAN PENGAWASAN SMART PJUTS BERBASIS MIKROKONTROLER
Authors: Aripriharta Aripriharta , Sastra Surya Yogi , Wongso Susilo Suhiro , Norma Mustika Soraya , - Sujito - 
Published: June 2023

Pemasangan Penerangan Jalan Umum Tenaga Surya (PJUTS) sudah banyak dilakukan, terutama di Indonesia. Pada tahun 2018, terdapat sebanyak 252.552 PJUTS yang terpasang di 16 provinsi, sesuai dengan data dari program LTSHE yang diselenggarakan oleh Kementerian ESDM.. PJUTS telah masuk dalam program pemerintah untuk mengganti PJU yang masih menggunakan daya dari PLN menjadi PJU dengan tenaga surya dengan mengubah PJU konvensional menjadi PJUTS dapat menghemat dana pemerintah yang biasa digunakan untuk membiayai pembayaran listrik untuk PJU. Penulis merancang sistem kontrol dan Pengawasaning PJUTS pintar berbasis mikrokontroler untuk mengatasi masalah yang sering dihadapi oleh PJUTS yang sudah terpasang. Sistem ini mampu mengatur tingkat penerangan PJUTS berdasarkan jumlah kendaraan yang melewati, daya baterai, dan intensitas cahaya. Selain itu, sistem ini dilengkapi dengan fitur Pengawasaning untuk memantau tegangan dan arus baterai output panel surya, lokasi pemasangan, keramaian lalu lintas, daya lampu, status lampu, serta konsumsi daya harian, bulanan, dan tahunan. Arduino Nano digunakan sebagai kontroler utama, dan data dipindahkan ke database web melalui modul NodeMCU Esp8266 Wifi. Untuk melacak lokasi PJUTS, sistem ini menggunakan GPS GY NEOMV2.
Kata Kunci: PJUTS, Microcontroller, Arduino, NodeMCUESP8266, GPS, Pengawasaning
Keanekaragaman Jenis Ikan yang Terdapat di Sungai Air Jernih Kecamatan Padang Guci Hulu Kabupaten Kaur Provinsi Bengkulu
Authors: Herlina Meti , Fitriani Apriza , Hermansyah Prasanto 
Published: June 2023

Abstract. This research aims at investigating the diversity of fish species contained in Air Jernih River Padang Guci Hulu District Kaur Regency Bengkulu Province. The method used in this research was the direct survey method to the research location. The sampling technique was conducted by dividing the station based on the characteristics of the river consisting of three locations, namely station A with the characteristics of the river that is rocky and mossy, the station B with the characteristics of the river that is rocks and pebbles (coral), and station C is with sandy river characteristics. From the research results, it can be revealed that the diversity of fish contained that the diversity contained in the three stations, having different fish diversity on station A with the index of diversity of 0.58, station B with the index of diversity of 0.57, and on station C with diversity index 0, 66. The types of fish contained in Air Jernih river of Padang Guci Hulu District Kaur Regency Bengkulu Province were containing 7 species belonging to 5 families. The fish species are: Gobiinae (Sicyopterus cynocephalus), Anabantidae (Anabas testudineus), Ciclidae (Oreochromis niloticus), Anguillidae (Anguilla marmorata), and Cyprinidae (Rasbora argyrotaenia, Barbonymus gonionotus and Osteochilus vittatus).Keywords: diversity, river fish air jernih
Pengaruh EWOM (Electronic Word of Mouth) di Instagram Terhadap Keputusan Berkunjung Wisata di Kota Tomohon
Authors: Oley Daniel , James D.D. Massie  , Imelda W.J. Ogi  
Published: June 2023

Penelitian penulis bertujuan untuk mengetahui indikator eWOM di media sosial Instagram terhadap keputusan berkunjung wisata di Kota Tomohon. Teknik pengambilan sampel menggunakan purposive sampling didasarkan atas pertimbangan penulis, responden merupakan pengunjung wisata di Kota Tomohon dan sudah mengikuti akun Dinas Pariwisata Kota Tomohon.Data penulis diperoleh dengan membagikan kuesioner tentang concern for other, expressing positive feeling, helping company, dan content kepada 100 responden dengan skala yang menjadi acuan pengukuran adalah likert.Analisis data menggunakan teknik analisis regresi berganda. Hasil dari penulisi teliti menunjukan bahwa concern for other, expressing positive feeling, helping company, dan content secara simultan berpengaruh terhadap Keputusan Berkunjung, namun Secara parsial Expresing Positve feeling kurang mempengaruhi keputusan berkunjung wisata di Kota Tomohon, bukan berarti dari variabel ini pengunjung tidak tertarik untuk mengunjungi tempat wisata di Kota Tomohon ada juga kemungkinan perasaan yang di gambarkan orang lain kurang tersampaikan ke responden lewat sosial media Instagram sehingga tanggapan dari responden kurang sesuai dengan harapan responden.
KataKunci: Concern for Other, Expressing Positive Feeling, Helping Company, Content, Keputusan Berkunjung
EVALUASI SISTEM DAN PROSEDUR AKUNTANSI PENGELUARAN KAS BELANJA LANGSUNG PADA BADAN PERENCANAAN PENELITIAN DAN PENGEMBANGAN DAERAH KOTA MANADO DIMASA PANDEMI COVID-19
Authors: Djafar Maqfira Apriani , Hendrik Manossoh  , Sherly Pinatik  
Published: June 2023

Penyelenggaraan Pemerintahan yang baik merupakan suatu tuntutan dalam kehidupan berbangsa dan bernegara tata pemerintahan yang baik (good governance) antara lain tercermin dari adanya pengelolaan keuangan pemerintah yang transparan dan akuntabel. Pengeluaran kas merupakan komponen sumber daya yang penting dalam pelaksanaan program-program yang sudah direncanakan oleh pemerintah dan harus dilaksanakan secara efektif dan efisien agar tidak terjadi pemborosan anggaran. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan sistem dan prosedur akuntansi pengeluaran kas pada bapelitbangda pada masa Pandemi Covid-19. Metode analisis yang digunakan dalam penelitian ini yaitu metode deskriptif yang dimulai dengan mengumpulkan data kemudian dianalisis untuk ditarik sebuah kesimpulan dan jenis penelitian yang digunakan adalah kualitatif deskriptif. Hasil penelitian yang diperoleh yaitu Sistem dan Prosedur Akuntansi Pengeluaran Kas Belanja Langsung di Badan Perencanaan Penelitian dan Pengembangan Daerah Kota Manado Dimasa Pandemi Covid-19 telah berjalan dan disesuaikan dengan Aturan Permendagri Nomor 77 Tahun 2020.

Kata Kunci: sistem dan prosedur; pengeluaran kas, akuntansi pemerintah.